TY  - JOUR
AU  - Beutler, J.A.
AU  - Shoemaker, R.H.
AU  - Johnson, T.
AU  - Boyd, M.R.
TI  - Cytotoxic geranyl stilbenes from Macaranga schweinfurthii [Language: en]
JO  - Journal of Natural Products
PY  - 1998/12/01/
VL  - 61
IS  - 12
SP  - 1509
SN  - 01633864
AV  - Location: *US (DNAL 442.8 L77); Number: 1999005614
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE; AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]; AGRIS; COMPOSITE RECORD. Database Contributor ID: 9868152; ALNAP-013764; US1999005614. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 9868152. Author Affiliation: Beutler, J.A. : National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 1; Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA 2; 
AB  - ALNAP Abstract: Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity
KW  - Maryland
KW  - Maryland
KW  - cancer
KW  - cytotoxic
KW  - cytotoxicity
KW  - development
KW  - drug
KW  - drug discovery
KW  - Euphorbiaceae
KW  - geranyl
KW  - geranyl stilbene
KW  - Isolated
KW  - laboratory
KW  - Macaranga schweinfurthii
KW  - mass spectral
KW  - mechanism
KW  - Methods
KW  - Natural Product
KW  - natural products
KW  - NCI
KW  - NMR
KW  - Novel
KW  - plant
KW  - products
KW  - research
KW  - spectral methods
KW  - stilbene
KW  - stilbenes
KW  - structure
KW  - structures
KW  - therapeutic
KW  - therapeutics
KW  - Three
KW  - cameroon
KW  - drug plants
KW  - leaves
KW  - chemical composition
KW  - aromatic compounds
KW  - spectrometry
KW  - chemical structure
KW  - toxic substances
KW  - antineoplastic agents
KW  - mankind
KW  - cell culture
KW  - cameroun
KW  - plante medicinale
KW  - feuille
KW  - composition chimique
KW  - compose aromatique
KW  - spectrometrie
KW  - structure chimique
KW  - substance toxique
KW  - medicament cytostatique
KW  - genre humain
KW  - culture de cellule
KW  - camerun
KW  - plantas medicinales
KW  - hojas
KW  - composicion quimica
KW  - compuestos aromaticos
KW  - espectrometria
KW  - estructura quimica
KW  - sustancias toxicas
KW  - agentes antineoplasticos
KW  - genero humano
KW  - cultivo de celulas
KW  - schweinfurthins
KW  - stelletins
KW  - cephalostatins
KW  - cns tumor-derived lines sf-295 and sf-539
KW  - spectral analysis
KW  - cytotoxic compounds
KW  - cell lines
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Naficy, A.B.
AU  - Abu-Elyazeed, R.
AU  - Holmes, J.L.
AU  - Rao, M.R.
AU  - Savarino, S.J.
AU  - Kim, Y.
AU  - Wierzba, T.F.
AU  - Peruski, L.
AU  - Lee, Y.J.
AU  - Gentsch, J.R.
AU  - Glass, R.I.
AU  - Clemens, J.D.
TI  - Epidemiology of rotavirus diarrhea in Egyptian children and implications for disease control
JO  - American Journal of Epidemiology
PY  - 1999/01/01/
VL  - 150
IS  - 7
SP  - 770
SN  - 00029262
N1  - Note: HEALTHLIT Location: University of Pretoria; Contract Number: Y1-HD-0026-01/HD/NICHD NIH HHS. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 0225249X; 10512431. Database Subset: AFRICAN HEALTHLINE. Corporate Author: National Institute of Child Health and Human Development. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 0225249X. Author Affiliation: Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20852, USA 1; 
AB  - MEDLINE Abstract: Reliable epidemiologic data are essential for formulating effective policy to control rotavirus disease through immunization. The objective of this study was to describe the epidemiology of rotavirus diarrhea in a population-based cohort of children under 3 years of age residing in Abu Homos, Egypt, in 1995-1996. Rotavirus diarrhea incidence rates (episodes per person-year) were 0.13 for infants aged <6 months, 0.61 for those aged 6-11 months, 0.17 for those aged 12-23 months, and 0.15 for those aged 24-35 months. Fifty-six percent of children with rotavirus diarrhea had clinical dehydration; 90% of rotavirus diarrheal episodes occurred between July and November. In infants under 1 year of age, receipt of breast milk was associated with a lower incidence of rotavirus diarrhea. No other sociodemographic or environmental factor was found to be significantly associated with rotavirus diarrhea. Of 46 rotavirus isolates with strains identified, 41 (89%) were G serotypes 1 and 2. Rotavirus diarrhea was a major cause of morbidity in this cohort. Promotion of breastfeeding may exert a protective effect in young infants in this setting, but improvements in water and sanitation are unlikely to be effective preventive measures. The use of effective immunization against rotavirus in early infancy should be considered a public health priority.;  This study describes the epidemiology of rotavirus diarrhea in a population-based cohort of children under 3 years of age residing in Abu Homos, Egypt, during 1995-96.  Samples consisted of a cohort of children under the age of 24 months assembled from two villages in the vicinity of Abu Homos.  The age-specific incidence rates of rotavirus diarrheal episodes per person-year were 0.13 for infants aged 6 months, 0.61 for those aged 6-11 months, 0.17 for those aged 12-23 months, and 0.15 for those aged 24-35 months.  No rotavirus diarrheal incidence occurred in infants under 20 weeks of age.  The monthly incidence rates of rotavirus diarrhea demonstrate that 90% of the disease episodes occurred during the warmer months of July-November, with a peak incidence in August.  In infants under 1 year of age, breast-feeding was associated with a lower incidence of rotavirus diarrhea.  Promotion of breast-feeding may employ a protective effect in young infants in this setting, but improvements in water and sanitation are unlikely to be effective preventive measures
KW  - Public health and Epidemiology (G600)
KW  - Public health and Epidemiology (G600)
KW  - North Africa
KW  - Egypt
KW  - Breast feeding
KW  - Waterborne diseases
KW  - Diarrhoea
KW  - Pathogenic viruses
KW  - Rotaviruses
KW  - Epidemiology
KW  - Children
KW  - Developing countries
KW  - Seasonal variations
KW  - Disease control
KW  - Future possibilities
KW  - Vaccines
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - BONKOVSKY, Frederick O
TI  - Ethical issues in perinatal HIV
JO  - Clinics in Perinatology
PY  - 1994/01/01/
VL  - 21
IS  - 1
SP  - 15
EP  - 28
SN  - 00955108
N1  - Note: AIDS CONSORTIUM Location: AIDS Consortium Resource Centre; CHILDREN; HEALTHLINK Location: CA/HC4.424. Database Contributor: HEALTHLINK WORLDWIDE; MEDLINE; AIDS CONSORTIUM RESOURCE CENTRE DATABASE; COMPOSITE RECORD. Database Contributor ID: HEALTHLINK-017852; 8013183; Legal-199500188. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: HEALTHLINK-017852. Author Affiliation: National Institutes of Health, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: Perinatal HIV raises difficult ethical issues and value conflicts for practitioners, patients, and the public. Part I gives an overview of US infant HIV realities and the devastating worldwide HIV and tuberculosis pandemics. In part II, the major ethical issues regarding perinatal HIV including confidentiality, advance directives, US rights, and right to medical care where HIV exists. Also reviewed are quality of life and death, consideration of selective and more general problems associated with prenatal and neonatal screening, and pregnancy termination and postponement where perinatal HIV is likely
KW  - CHILDREN
KW  - diseases and disease control
KW  - hiv [aids]
KW  - CHILDREN
KW  - diseases and disease control
KW  - hiv [aids]
KW  - INFANTS
KW  - CHILDREN
KW  - ETHICS, MEDICAL
KW  - QUALITY OF LIFE
KW  - ABORTION
KW  - PAEDIATRIC AIDS
KW  - STATISTICS
KW  - TRANSMISSION, MOTHER TO CHILD
KW  - abortion
KW  - children
KW  - counselling
KW  - ethical issues
KW  - HIV infection
KW  - resource allocation
KW  - transmission - maternal
KW  - women
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=HEALTHLINK-017852&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Quinn, T C
TI  - Global burden of the HIV pandemic
JO  - Lancet
PY  - 1996/01/01/
VL  - 348
IS  - 9025 | 9020
SP  - 99
EP  - 106
N1  - Note: AIDS CONSORTIUM Location: AIDS Consortium Resource Centre; HIV EPIDEMIC. Database Contributor: AIDS CONSORTIUM RESOURCE CENTRE DATABASE; MEDLINE; COMPOSITE RECORD. Database Contributor ID: Legal-199700570; 8676726. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: Legal-199700570. Author Affiliation: National Institute of Allergy and Infectious Diseases, Baltimore, Maryland, USA 1; 
AB  - MEDLINE Abstract: Within the global pandemic of HIV infection there are many different epidemics, each with its own dynamics and each influenced by many factors including time of introduction of the virus, population density, and cultural and social issues. Effective management strategies depend on knowledge of all these factors. By the year 2000, WHO projections are that 26 million persons will be infected with HIV, more than 90% of whom will be in developing countries. To control AIDS, countries must not only promote changes in individual behaviour but also address social issues such as unemployment, rapid urbanisation, migration, and the status of women.;  The world is currently experiencing a global pandemic of HIV infection.  There are, however, many different epidemics within the global pandemic of HIV, each with its own dynamics and each influenced by many factors, including the time of introduction of the virus, population density, and cultural and social issues.  Effective management strategies depend upon knowledge of all these factors.  By the year 2000, the World Health Organization projects that 26 million people will be infected with HIV, more than 90% of whom will be in developing countries.  The author stresses that to control AIDS, countries must not only promote changes in individual behavior, but also address social issues such as unemployment, rapid urbanization, migration, and women's status.  This paper describes the epidemiological features of the HIV pandemic, including its evolution, economic and demographic impacts, unique characteristics in different regions of the world, and projections for the next four years
KW  - HIV EPIDEMIC
KW  - International
KW  - HIV EPIDEMIC
KW  - International
KW  - HIV EPIDEMIC
KW  - PLANNING
KW  - DEVELOPING COUNTRIES
KW  - SEXUAL BEHAVIOUR CHANGE
KW  - SOCIOECONOMIC ASPECTS
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Grady, C
TI  - Grappling with global concerns in the search for an HIV vaccine
JO  - Association of Nurses in AIDS Care. Journal
PY  - 1999/01/01/
VL  - 10
IS  - 1
SP  - 17
EP  - 20
PB  - Elsevier Inc.: 625 Walnut St, Curtis Ctr, Philadelphia, PA 19106 United States
SN  - 10553290
N1  - Database Contributor: AFRICAN DEVELOPMENT DATABASE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: AFD-1060720; 1060720. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: AFD-1060720. Author Affiliation: [1999-2007] - Human Subjects Research, Department of Clinical Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892-1156, USA 1; 
AB  - AFRICAN DEVELOPMENT Abstract: There is a need for increasing international collaboration in the search for a safe and effective HIV vaccine. In addition to the ethical issues that must be considered in conducting any clinical research, unique issues arise in vaccine research and in international research. Careful deliberation and guideline development regarding the ethics of international vaccine research was the focus of a series of recent consultations sponsored by Joint United Nations Programme on HIV/AIDS (UNAIDS) around the world
KW  - Microbiology / Biotechnology
KW  - Bacteria / Fungi / Viruses
KW  - Diseases / Pathogens
KW  - Experimental research
KW  - Health / Public health
KW  - Medical Science
KW  - Biochemistry / Molecular biology
KW  - World
KW  - Microbiology / Biotechnology
KW  - Bacteria / Fungi / Viruses
KW  - Diseases / Pathogens
KW  - Experimental research
KW  - Health / Public health
KW  - Medical Science
KW  - Biochemistry / Molecular biology
KW  - World
KW  - hiv [human immunodeficiency virus]
KW  - hiv vaccine
KW  - hiv vaccine development
KW  - biochemical research
KW  - antiviral activities
KW  - vaccine research
KW  - hiv prevention
KW  - hiv transmission
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=AFD-1060720&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Fuller, R.W.
AU  - Blunt, J.W.
AU  - Boswell, J.L.
AU  - Cardellina, J.H. II.
AU  - Boyd, M.R.
AU  - Cardellina II JH
TI  - Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii [Language: en]
JO  - Journal of Natural Products
PY  - 1999/01/01/
VL  - 62
IS  - 1
SP  - 130
EP  - 132
SN  - 01633864
AV  - Location: *US (DNAL 442.8 L77); Number: 1999004127
N1  - Database Contributor: AGRIS; AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]; COMPOSITE RECORD. Database Contributor ID: US1999004127; ALNAP-008457. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US1999004127. Author Affiliation: Fuller, R.W. : National Cancer Institute, Frederick, MD 1; 
AB  - ALNAP Abstract: The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F(1). The structure was solved by extensive NMR analyses and by acid-catalyzed conversion to 30-epi-cambogin (4). This is the first report of this compound type in the genus Allanblackia
KW  - Africa
KW  - Tanzania
KW  - Africa
KW  - Tanzania
KW  - tanzania
KW  - guttiferae
KW  - drug plants
KW  - roots
KW  - wood
KW  - chemical composition
KW  - benzoic acid
KW  - spectrometry
KW  - chemical structure
KW  - mankind
KW  - herpetoviridae
KW  - antimicrobial properties
KW  - tanzanie
KW  - plante medicinale
KW  - racine
KW  - bois
KW  - composition chimique
KW  - acide benzoique
KW  - spectrometrie
KW  - structure chimique
KW  - genre humain
KW  - propriete antimicrobienne
KW  - plantas medicinales
KW  - raices
KW  - madera
KW  - composicion quimica
KW  - acido benzoico
KW  - espectrometria
KW  - estructura quimica
KW  - genero humano
KW  - propiedades antimicrobianas
KW  - clusiaceae
KW  - derivatives
KW  - spectral analysis
KW  - human immunodeficiency virus
KW  - antiviral properties
KW  - activity
KW  - Africa
KW  - benzophenone
KW  - bioassay-guided
KW  - compound
KW  - extract
KW  - extracts
KW  - Fractionation
KW  - Genus
KW  - new
KW  - NMR
KW  - NMR analysis
KW  - report
KW  - structure
KW  - via
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Quinn, T C
TI  - Population migration and the spread of types 1 and 2 human immunodeficiency viruses
JO  - National Academy of Sciences of the United States of America. Proceedings
PY  - 1994/01/01/
VL  - 91
IS  - 7
SP  - 2407
EP  - 2414
SN  - 00278424
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; AIDS CONSORTIUM Location: AIDS Consortium Resource Centre; DEMOGRAPHY. Database Contributor: MEDLINE; AIDS CONSORTIUM RESOURCE CENTRE DATABASE; COMPOSITE RECORD. Database Contributor ID: 8146131; Legal-199600944. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 8146131. Author Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 1; 
AB  - MEDLINE Abstract: Over 14 million people are estimated to be infected with the human immunodeficiency viruses (HIV), with nearly three-fourths of the infected persons residing in developing countries. One factor responsible for dissemination of both HIV-1 and HIV-2 worldwide was the intense migration of individuals, from rural to urban centers with subsequent return migration and internationally due to civil wars, tourism, business purposes, and the drug trade. In sub-Saharan Africa, between 1960 and 1980, urban centers with more than 500,000 inhabitants increased from 3 to 28, and more than 75 military coups occurred in 30 countries. The result was a massive migration of rural inhabitants to urban centers concomitant with the spread of HIV-1 to large population centers. With the associated demographic, economic, and social changes, an epidemic of sexually transmitted diseases and HIV-1 was ignited. Migratory patterns were also responsible for the spread of endemic HIV-2 to neighboring West African countries and eventually to Europe, the Americans, and India. Although Southeast Asia was the last region in which HIV-1 was introduced, it has the greatest potential for rapid spread due to population density and inherent risk behaviors. Thus, the migration of poor, rural, and young sexually active individuals to urban centers coupled with large international movements of HIV-infected individuals played a prominent role in the dissemination of HIV globally. The economic recession has aggravated the transmission of HIV by directly increasing the population at risk through increased urban migration, disruption of rural families and cultural values, poverty, and prostitution and indirectly through a decrease in health care provision. Consequently, social and economic reform as well as sexual behavior education need to be intensified if HIV transmission is to be controlled
KW  - DEMOGRAPHY
KW  - AFRICA
KW  - UNITED STATES OF AMERICA
KW  - ASIA
KW  - DEMOGRAPHY
KW  - AFRICA
KW  - UNITED STATES OF AMERICA
KW  - ASIA
KW  - DEMOGRAPHY
KW  - EPIDEMIOLOGY
KW  - MIGRANT WORKERS
KW  - IMMIGRANTS
KW  - REFUGEES
KW  - TRAVEL AND TRAVELLERS
KW  - HIV-1
KW  - HIV-2
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Cardellina, J H., 2nd
AU  - Beutler, J.A.
AU  - Kashman, Y.
AU  - Tischler, M.
AU  - Cardellina, J.H. II.
AU  - Gray, G.N.
AU  - Currens, M.J.
AU  - Wall, M.E.
AU  - Wani, M.C.
AU  - Boyd, M.R.
TI  - A reinvestigation of Maprounea triterpenes [Language: en]
JO  - Journal of Natural Products
PY  - 1995/07/01/
VL  - 58
IS  - 7
SP  - 1039
EP  - 1046
SN  - 01633864
AV  - Location: *US (DNAL 442.8 L77); Number: 9559717
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 37558-16-0. Database Contributor: MEDLINE; AGRIS; COMPOSITE RECORD. Database Contributor ID: 7561897; US9559717. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 7561897. Author Affiliation: Beutler, J.A. : National Cancer Institute, Frederick, MD 1; Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA 2; 
AB  - MEDLINE Abstract: Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group
KW  - drug plants
KW  - central african republic
KW  - euphorbiaceae
KW  - spectrometry
KW  - chemical composition
KW  - triterpenoids
KW  - mankind
KW  - herpetoviridae
KW  - antiviral agents
KW  - esters
KW  - reverse transcriptase
KW  - enzyme inhibitors
KW  - plante medicinale
KW  - republique centrafricaine
KW  - spectrometrie
KW  - composition chimique
KW  - triterpenoide
KW  - genre humain
KW  - antiviral
KW  - ester
KW  - transcriptase inverse
KW  - inhibiteur d'enzyme
KW  - plantas medicinales
KW  - republica centroafricana
KW  - espectrometria
KW  - composicion quimica
KW  - triterpenoidos
KW  - genero humano
KW  - viricidas
KW  - esteres
KW  - transcriptasa inversa
KW  - inhibidores de enzimas
KW  - phorbol
KW  - maprounea membranaceae
KW  - maprounea africana
KW  - molecular structure
KW  - medicinal plants
KW  - spectral analysis
KW  - molecular conformation
KW  - human immunodeficiency virus
KW  - binding site
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7561897&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Blasco, R.
AU  - Lopez-Otin, C.
AU  - Munoz, M.
AU  - Bockamp, E.O.
AU  - Simon-Mateo, C.
AU  - Vinuela, E.
AU  - López-Otín, C
AU  - Muñóz, M
AU  - Simón-Mateo, C
AU  - Viñuela, E
TI  - Sequence and evolutionary relationships of African swine fever virus thymidine kinase [Language: en]
JO  - Virology
PY  - 1990/09/01/
VL  - 178
IS  - 1
SP  - 301
EP  - 304
SN  - 00426822
AV  - Location: US; Number: 9112435
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; EC Number: 2.7.1.21; Molecular Sequence: GENBANK/M31715. Database Contributor: AGRIS; MEDLINE; COMPOSITE RECORD. Database Contributor ID: US9112435; 2389555. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9112435. Author Affiliation: Blasco, R. : National Institute of Allergy and Infectious Diseases, NIH 1; Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Canto Blanco, Madrid, Spain 2; 
AB  - MEDLINE Abstract: The thymidine kinase gene of African swine fever virus was mapped in a 1.4-kb EcoRI-PstI fragment located in the left half of the Eco RI K fragment of African swine fever virus DNA by using degenerate oligonucleotide probes derived from regions of the thymidine kinase sequence conserved in several poxviruses, man, mouse, and chicken. The nucleotide sequence of this region revealed an open reading frame of 196 codons, whose translated amino acid sequence showed significant similarity to the thymidine kinases of vaccinia virus, variola virus, monkeypox virus, shope fibroma virus, fowlpox virus, capripox virus, man, mouse, and chicken. The similarity scores obtained after comparison of known thymidine kinase sequences indicated that the African swine fever virus thymidine kinase is more distantly related than the poxvirus thymidine kinases to their cellular homologs. The evolutionary implications of these findings are discussed
KW  - african swine fever virus
KW  - transferases
KW  - nucleotides
KW  - dna
KW  - nucleotide sequence
KW  - genes
KW  - phylogeny
KW  - virus peste porcine africaine
KW  - transferase
KW  - nucleotide
KW  - adn
KW  - sequence nucleique
KW  - gene
KW  - phylogenie
KW  - virus de la peste porcina africana
KW  - transferasas
KW  - nucleotidos
KW  - secuencia nucleica
KW  - filogenia
KW  - amino acid sequences
KW  - dna sequencing
KW  - gene mapping
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Schwan, T.G.
TI  - Sex ratio and phoretic mites of fleas [Siphonaptera: Pulicidae and Hystrichopsyllidae] on the Nile grass rat [Arvicanthis niloticus] in Kenya [Language: en]
JO  - Journal of Medical Entomology
PY  - 1993/01/01/
VL  - 30
IS  - 1
SP  - 122
EP  - 135
SN  - 00222585
AV  - Location: *US (DNAL 421 J828); Number: 9409687
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: AGRIS; MEDLINE; COMPOSITE RECORD. Database Contributor ID: US9409687; 8433319. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9409687. Author Affiliation: Schwan, T.G. : National Institute of Allergy and Infectious Diseases, Hamilton, MT 1; Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840 2; 
AB  - The sex ratio of fleas and their phoretic mites associated with the Nile grass rat, Arvicanthis niloticus (Desmarest), were studied during 14 mo in a grassland community of Lake Nakuru National Park, Kenya. Females of the fleas Dinopsyllus lypusus jordan and Rothschild, Ctenophthalmus calceatus cabirus Jordan and Rothschild, and Xenopsylla cheopis bantorum Jordan infested more grass rats and in greater numbers than did males. Phoretic hypopi (heteromorphic deutonymphs) of two species of mites, Psylloglyphus uilenbergi Fain and Paraceroglyphus xenopsylla Fain and Schwan, varied seasonally in their abundance on fleas and utilized female fleas over male fleas for their major source of transport. Additionally, the mites were very host specific with nearly 100% of those identified on D. lypusus and C. calceatus cabirus being P. uilenbergi and 89% of the mites identified on X. cheopis bantorum being P. xenopsylla. This level of specificity suggests that these mite-flea associations are highly evolved. The importance of female fleas as hosts for transporting mites also suggests that female-biased sex ratios of fleas on their hosts may be caused, in part, by females being more important as dispersers within flea populations
KW  - kenya
KW  - acarina
KW  - pulicidae
KW  - hystrichopsyllidae
KW  - insecte nuisible
KW  - sex ratio
KW  - rodentia
KW  - relation hote parasite
KW  - kenia
KW  - insectos daninos
KW  - proporcion de los sexos
KW  - relaciones huesped parasito
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - MOFENSON, Lynne M
TI  - Short-course zidovudine for prevention of perinatal infection
JO  - Lancet
PY  - 1999/01/01/
VL  - 353
IS  - 9155
SP  - 766
EP  - 767
N1  - Note: CAS Registry Number: 4B9XT59T7S. Database Contributor: HEALTHLINK WORLDWIDE; MEDLINE; COMPOSITE RECORD. Database Contributor ID: HEALTHLINK-023537; 10459952. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: HEALTHLINK-023537. Author Affiliation: Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA 1; 
AB  - MEDLINE Abstract: In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) protocol 076 showed that a 6-week course of zidovudine, given to the mother during pregnancy and labor, and then to the neonate for 6 weeks, reduced HIV transmission rates by almost 70%.  The adoption of this regimen in the US and Europe has caused perinatal HIV transmission rates to decline to 6% or less, while transmission rates of 2% have been reported when zidovudine prophylaxis is combined with elective cesarean delivery.  However, in absolute terms, the impact of perinatal HIV transmission prevention measures will be greater in developing than in industrialized countries, in part because the overall level of HIV infection among pregnant women in developing countries is far higher than the overall level in industrialized countries.  While trials must continue to identify simpler and more cost-effective HIV prevention measures, effort must still be given to implementing the already proven effective regimens in developing countries.  To implement short-course HIV prophylactic regimens requires available and accessible antenatal care, HIV testing and follow-up for pregnant women, available and affordable zidovudine, and patient compliance with the drug regimen.  To ensure intrapartum zidovudine administration, deliveries must be attended by professional birth attendants.  Then, to prevent postpartum HIV transmission, there must be a safe and effective strategy for reducing the risk of HIV-1 transmission through breast milk
KW  - diseases and disease control
KW  - hiv [aids]
KW  - diseases and disease control
KW  - hiv [aids]
KW  - antenatal care
KW  - breastfeeding
KW  - drug research
KW  - drug treatment
KW  - health costs
KW  - HIV
KW  - HIV prevention
KW  - transmission
KW  - transmission - maternal
KW  - zidovudine
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=HEALTHLINK-023537&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Daly JW
TI  - Thirty Years of Discovering Arthropod Alkaloids in Amphibian Skin
JO  - Journal of Natural Products
PY  - 1998/01/01/
VL  - 61
IS  - 1
SP  - 162
EP  - 172
SN  - 01633864
N1  - Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]; COMPOSITE RECORD. Database Contributor ID: ALNAP-013492; ALNAP-013601. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-013492. Author Affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 (John William Daly) 1; 
AB  - ALNAP Abstract: Amphibian skin has provided a wide range of biologically active alkaloids. During the past 30 years, over 400 alkaloids of over 20 structural classes have been detected. These include the batrachotoxins, which are potent and selective activators of sodium channels, the histrionic- otoxins, which are potent noncompetitive blockers of nicotinic receptor-gated channels, the pumiliotoxins and related allo- and homo-pumiliotoxins, which have myotonic and cardiotonic activity due to effects on sodium channels, and epibatidine, which has potent antinociceptive activity due to agonist activity at nicotinic receptors. Further classes of alkaloids from amphibian skin include pyrrolidines and piperidines, decahydroquinolines, pyrrolizidines, various indolizidines, quinolizidines, and tricyclic gephyrotoxins, pyrrolizidine oximes, pseudophrynamines, coccinellines, and cyclopentaquinolizidines. Most alkaloids of amphibian skin appear to be sequestered from dietary arthropods. The source of the batrachotoxins, histrionicotoxins, pumiliotoxins, epibatidine, and certain izidines are unknown.; Amphibian skin has provided a wide range of biologically active alkaloids. During the past 30 years, over 400 alkaloids of over 20 structural classes have been detected. These include the batrachotoxins, which are potent and selective activators of sodium channels, the histrionicotoxins, which are potent knoncompetitive blockers of nicotinic receptor-gated channels, the pumiliotoxins and related allo-and homo-pumiliotoxins, which have myotonic and carodiotonic activity due to effects on sodium channels, and epibatidine, which hs potent antinociceptive activity due to agonist activity at nicotinic receptors. Furhter classes of alkaloids from amphibian skin include pyrrolidines and piperidines, decahydroquinlines, pyrrolizidines, various indloizidines, quinolizidines, and tricyclic gephyrotoxins, pyrrolizidine oximes, pseudophrynamines, coccinellines, and cyclopentaquinolizidines. Most alkaloids of amphibian skin appear to be sequestered from dietary arthropods. The source of the batrachotoxins, histrionicotoxins, pumiliotoxins, epibatidine, and certain izidines are unknown
KW  - Maryland
KW  - England
KW  - Maryland
KW  - England
KW  - activity
KW  - alkaloid
KW  - Alkaloids
KW  - Antinociceptive
KW  - Antinociceptive activity
KW  - Arthropod
KW  - Batrachotoxin
KW  - Biologically
KW  - cardiotonic
KW  - chemistry
KW  - diabetes
KW  - diseases
KW  - effect
KW  - health
KW  - Histrionicotoxin
KW  - indolizidine
KW  - Indolizidines
KW  - kidney
KW  - laboratory
KW  - Nicotinic receptor
KW  - Oxime
KW  - piperidine
KW  - Piperidines
KW  - Pyrrolidines
KW  - pyrrolizidine
KW  - pyrrolizidines
KW  - quinolizidine
KW  - related
KW  - Selective
KW  - skin
KW  - sodium
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Tsai, W-P
AU  - Kung, H-F.
AU  - Nara, PL.
TI  - The presence and absence of histocompatibility antigens in HIV Type 1 produced by autologous blood-derived macrophages and peripheral blood lymphoblasts
JO  - AIDS Research and Human Retroviruses
PY  - 1999/01/01/
VL  - 15
IS  - 1
SP  - 33
EP  - 41
PB  - Mary Ann Liebert, Inc. Publishers: 140 Huguenot Street, 3rd Floor, New Rochelle, New York, 10801-5215, USA
SN  - 08892229
N1  - Note: HEALTHLIT Location: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. Database Contributor: HEALTHLIT; AFRICAN DEVELOPMENT DATABASE; COMPOSITE RECORD. Database Contributor ID: 923405. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 923405. Author Affiliation: [1999] - Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA 1; Locations: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. 
AB  - AFRICAN DEVELOPMENT Abstract: Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic isolate, HIV-1ADA, grown from autologous monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs). A virus precipitation assay (VPA) demonstrated that HIV-1ADA grown from PBMCs incorporated substantial amounts of HLA class I (alpha chain and beta2m) and DR antigens, comparable with a laboratory strain, HIV-1MN, grown from the same host cells. HIV-1ADA, however, grown from MDMs incorporated significantly lower amounts of HLAI and-II antigens despite the fact that the infected MDMs were found to express significant amounts of HLA antigens. The lack of incorporation of these important immunomodulatory cell surface proteins may be yet another unique characteristic of macrophage-tropic isolates and suggests a possible role in their biology and or immunology
KW  - Bacteria / Fungi / Viruses
KW  - Laboratory experiments
KW  - Biochemistry / Molecular biology
KW  - Microbiology / Biotechnology
KW  - Genetics / Strains / Stock identification
KW  - North America
KW  - United States
KW  - Maryland
KW  - Bacteria / Fungi / Viruses
KW  - Laboratory experiments
KW  - Biochemistry / Molecular biology
KW  - Microbiology / Biotechnology
KW  - Genetics / Strains / Stock identification
KW  - North America
KW  - United States
KW  - Maryland
KW  - hiv-1 antigens
KW  - blood-derived macrophages
KW  - antigens
KW  - immunology
KW  - host cells
KW  - virus physiology
KW  - autogolous macrophages
KW  - t cells
KW  - cellular proteins
KW  - blood lymphoblasts
KW  - hiv-1 [human immunodeficiency virus type 1]
KW  - hiv-1 virions
KW  - histocompatibility
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Jain, P.
AU  - Garraffo, H.M.
AU  - Yeh, H.J.C.
AU  - Spande, T.F.
AU  - Daly, J.W.
AU  - Andriamaharavo, N.R.
AU  - Andriantsiferana, M.
TI  - A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog [Mantella] [Language: en]
JO  - Journal of Natural Products
PY  - 1996/12/01/
VL  - 59
IS  - 12
SP  - 1174
EP  - 1178
SN  - 01633864
AV  - Location: *US (DNAL 442.8 L77); Number: 9706599
N1  - Database Contributor: AGRIS. Database Contributor ID: US9706599. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9706599. Author Affiliation: Jain, P. : National Institutes of Health, Bethesda, MD 1; 
KW  - madagascar
KW  - frogs
KW  - skin
KW  - chemical composition
KW  - alkaloids
KW  - spectrometry
KW  - chemical structure
KW  - chemistry
KW  - grenouille
KW  - peau
KW  - composition chimique
KW  - alcaloide
KW  - spectrometrie
KW  - structure chimique
KW  - chimie
KW  - rana
KW  - piel [animal]
KW  - composicion quimica
KW  - alcaloides
KW  - espectrometria
KW  - estructura quimica
KW  - quimica
KW  - quinolizidine alkaloids
KW  - spectral analysis
KW  - stereochemistry
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Rockey, D.D.
AU  - Chesebro, B.B.
AU  - Heinzen, R.A.
AU  - Hackstadt, T.
TI  - A 28 kDa major immunogen of Chlamydia psittaci shares identity with Mip proteins of Legionella spp. and Chlamydia trachomatis - cloning and characterization of the C. psittaci mip-like gene [Language: en]
JO  - Microbiology
PY  - 1996/01/01/
VL  - 142
IS  - 4
SP  - 945
EP  - 953
AV  - Location: GB; Number: 9625179
N1  - Database Contributor: AGRIS. Database Contributor ID: GB9625179. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: GB9625179. Author Affiliation: Hackstadt, T. : Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840 USA 1; 
KW  - guinea pigs
KW  - conjunctivitis
KW  - gene expression
KW  - nucleotide sequence
KW  - chlamydia psittaci
KW  - viruses
KW  - proteins
KW  - cobaye
KW  - conjonctivite
KW  - expression des genes
KW  - sequence nucleotidique
KW  - virus
KW  - proteine
KW  - cobaya
KW  - conjuntivitis
KW  - expresion genica
KW  - secuencia nucleotidica
KW  - proteinas
KW  - epitopes
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Magrath, I T
TI  - African Burkitt's lymphoma. History, biology, clinical features, and treatment
JO  - The American journal of pediatric hematology/oncology
PY  - 1991/01/01/
VL  - 13
IS  - 2
SP  - 222
EP  - 246
SN  - 01928562
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2069232. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2069232. Author Affiliation: Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Dennis Burkitt's first description of the African tumor that is now known by his name appeared in 1958. In the brief intervening span of 32 years, this lymphoma has provided an extraordinarily valuable paradigm that has afforded insights into topics that encompass the entire discipline of oncology. These include the origins of lymphoid neoplasms at epidemiological, cellular, and molecular levels, and the efficacy of chemotherapy in rapidly progressive, widely disseminated lymphomas. In addition, epidemiological considerations led to the discovery of a new virus, the Epstein-Barr virus, which has proved to be an important human pathogen. This virus probably plays a pathogenetic role in several neoplastic diseases, including the lymphoproliferative syndromes associated with inherited and acquired immunodeficiency. Small, noncleaved cell lymphoma is the latest histological designation of the category of lymphomas that includes Burkitt's lymphoma. This tumor, which is biologically heterogeneous, has become notorious because of its high incidence in individuals infected with the human immunodeficiency virus, which is providing a second, potentially fertile model for the exploration of the pathogenesis of lymphoid neoplasms. Already, enough is known of the pathogenesis of Burkitt's lymphoma to permit the first tentative steps toward the development of novel therapeutic approaches directed toward the molecular genetic abnormalities associated with the neoplasm. In this article, the history, biology, clinical features, and treatment of African Burkitt's lymphoma are reviewed
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Williams, J K
TI  - Afro-American women living with HIV infection: special therapeutic interventions for a growing population
JO  - Social Work in Health Care
PY  - 1995/01/01/
VL  - 21
IS  - 2
SP  - 41
EP  - 53
SN  - 00981389
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8553198. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8553198. Author Affiliation: HIV Counseling Program, National Institutes of Health, Bethesda, MD, USA 1; 
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Biggar, R J
TI  - AIDS and HIV infection: estimates of the magnitude of the problem worldwide in 1985/1986
JO  - Clinical Immunology and Immunopathology
PY  - 1987/01/01/
VL  - 45
IS  - 3
SP  - 297
EP  - 309
SN  - 00901229
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3677488. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3677488. Author Affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: This review summarizes observations about the distribution of AIDS and HIV infection throughout the world. The United States has reported the greatest number of cases to the World Health Organization (WHO), but data from many areas are lacking or incomplete, making comparisons between different areas unreliable. Even within the United States, data are difficult to interpret and require careful consideration of the size of the various HIV-risk groups in the population and the degree to which results of studies of selected cohorts within a risk group can be extrapolated to the whole of that population. Outside of the United States, Europe, and Australia, less information is available. Almost every country in South America has reported cases of AIDS, although in most reports the number is small. In Asia, many countries have not yet reported cases or have had only a small number of cases. By the end of 1986, many countries in Africa had not yet reported any AIDS cases to the WHO, even from areas where AIDS is known to occur (i.e., Zaire). However, there is ample evidence from regional studies in Africa that AIDS and HIV infection are a major public health problem. Using admittedly questionable information for estimating the size of the problem worldwide, I project that between two and three million persons worldwide were infected with HIV by 1985/1986. Despite the lack of an effective therapy or vaccine, much can be and is being done to limit the global spread of HIV infection and AIDS
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Biggar, R J
TI  - AIDS in subsaharan Africa
JO  - Cancer detection and prevention. Supplement: official publication of the International Society for Preventive Oncology, Inc
PY  - 1987/01/01/
VL  - 1
SP  - 487
EP  - 491
SN  - 10436995
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3480062. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3480062. Author Affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20205 1; 
AB  - MEDLINE Abstract: AIDS has existed in subsaharan Africa at least since 1980. However, the genesis of this condition and its emergence as a health problem remain obscured by lack of data and by antibody data that are now questionable. In Africa, as elsewhere, AIDS is associated with an immunodeficiency associated with the LAV/HTLV-III retrovirus. The clinical manifestations vary somewhat because of the different range of opportunistic pathogens in that environment. Although the "classical," more indolent, endemic form of African Kaposi sarcoma is not associated with this virus or with immunodeficiency, a new, aggressive variety of Kaposi sarcoma in Africa appears to be. The origin of LAV/HTLV-III remains unclear, but the clinical syndrome of AIDS has emerged in Africa only in the past decade. A pattern of geographic spread can be recognized, in which AIDS was seen earliest in Kinshasa, Zaïre, and then emerged in Zambia, Rwanda, and Uganda. Recently, reports indicate spread into Tanzania and Kenya. Transmission appears to be primarily heterosexual, but the factors enhancing heterosexual spread in Africa to a greater extent than in the U.S. and Europe need to be further studied
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Willoughby, A
TI  - AIDS in women: epidemiology
JO  - Clinical Obstetrics and Gynecology
PY  - 1989/01/01/
VL  - 32
IS  - 3
SP  - 429
EP  - 436
SN  - 00099201
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2776374. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2776374. Author Affiliation: National Institute of Child Health and Human Development, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Several facts concerning the distribution of AIDS in U.S. female populations are clear. This disease has made significant inroads, in a quantitative sense, into the female segment of our society as documented by AIDS surveillance data, information on pregnant women and parturients, and by screening data from the military. The impact on women in the reproductive years, on the reproductive health of these women, and on the reproductive outcome of their pregnancies is of substantial concern. Monitoring epidemiologic trends in certain groups will require clever and creative strategies like those of Hoff and colleagues. Additional data may be derived from the CDC's Family of Surveys that will examine HIV prevalence in five groups (in addition to the newborn infant survey described above): intravenous drug users, patients admitted to hospitals, sexually transmitted disease clinic patients, women's health and reproductive health clinics, and tuberculosis clinics. It is hoped that the data obtained from these studies, as well as data gathered on college students and Job Corps applicants, will contribute additional information on HIV infection in women. Monitoring the progress of the AIDS epidemic in women will be difficult. Even more difficult will be the effort to respond to the epidemic in the women it most frequently affects: the poor, minority, disenfranchised women who may be involved in illegal activities (drug use, prostitution, illegal immigration) who are not well networked into the medical and social services of our society
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Cohen, S G
TI  - Al-Afdal [1169-1225] Arab Sultan of Damascus and Egypt
JO  - Allergy proceedings: the official journal of regional and state allergy societies
PY  - 1995/01/01/
VL  - 16
IS  - 4
SP  - 214
EP  - 215
SN  - 10469354
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; Named Person: Al-Afdal. Database Contributor: MEDLINE. Database Contributor ID: 8566731. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8566731. Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 1; 
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Bokesch HR
AU  - Blunt JW
AU  - Westergaard CK
AU  - Cardellina II JH
AU  - Johnson TR
AU  - Michael JA
AU  - Mckee TC
AU  - Hollingshead MG
AU  - Boyd MR
TI  - Alertenone, a Dimer of Suberosenone from Alertigorgia sp
JO  - Journal of Natural Products
PY  - 1999/01/01/
VL  - 62
IS  - 4
SP  - 633
EP  - 635
SN  - 01633864
N1  - Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-013929. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-013929. Author Affiliation: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederrick, Maryland 21702-1201 (Michael R. Boyd) 1; 
AB  - ALNAP Abstract: Bioassay-guided fractionation of organic extracts of the gorgonian Alertigorgia sp. has yielded the previously known suberosenone (1), a cytotoxic tricyclic sesquiterpene of the quadrone class, and alertenone (2), a climer of suberosenone. The structure of 2 was determined by spectral analysis; the 1D TOCSY experiment was particularly useful in the structure elucidation. Comparison of the in vitro cytotoxicity of alertenone and suberosenone revealed that the dimeric alertenone was devoid of cytotoxicity below 35 mg/mL. In a hollow-fiber assay model of in vivo activity, suberosenone eXhibited some growth inhibition of two of six tumor cell lines tested
KW  - Australia
KW  - Australia
KW  - activity
KW  - analysis
KW  - Australia
KW  - bioassay-guided
KW  - cancer
KW  - cancer treatment
KW  - cell
KW  - cell line
KW  - cytotoxic
KW  - cytotoxicity
KW  - development
KW  - dimer
KW  - Division
KW  - drug
KW  - drug discovery
KW  - elucidation
KW  - experiment
KW  - extract
KW  - extracts
KW  - Fractionation
KW  - Gorgonian
KW  - growth
KW  - growth inhibition
KW  - in vitro
KW  - in vitro cytotoxicity
KW  - in vivo
KW  - inhibition
KW  - laboratory
KW  - organic
KW  - organic extract
KW  - Organic extracts
KW  - research
KW  - Sesquiterpene
KW  - SP
KW  - spectral analysis
KW  - structure
KW  - structure elucidation
KW  - therapeutic
KW  - therapeutics
KW  - treatment
KW  - vivo
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Berzofsky, J A
TI  - Antigenic peptide interaction with MHC molecules: implications for the design of artificial vaccines
JO  - Seminars in Immunology
PY  - 1991/01/01/
VL  - 3
IS  - 4
SP  - 203
EP  - 216
SN  - 10445323
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1932704. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1932704. Author Affiliation: Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814 1; 
AB  - MEDLINE Abstract: Both helper and cytotoxic T cells see primarily a limited number of immunodominant sites on a protein. The reasons for immunodominance are many. We have explored primarily the roles of antigen processing and binding to histocompatibility molecules, as well as the structural features of the antigenic peptide. This information has led to the identification and characterization of sites stimulating helper or cytotoxic T cells specific for antigens from malaria or HIV, and ways to couple and immunize with these, that may be useful for vaccine development. We also observed a striking concordance between helper and cytotoxic T cell sites
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Rabkin, C S
TI  - Association of non-acquired immunodeficiency syndrome-defining cancers with human immunodeficiency virus infection
JO  - National Cancer Institute. Journal. Monographs
PY  - 1998/01/01/
IS  - 23
SP  - 23
EP  - 25
SN  - 10526773
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9709298. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9709298. Author Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA 1; 
AB  - MEDLINE Abstract: Kaposi's sarcoma and non-Hodgkin's lymphoma were among the earliest recognized manifestations of the acquired immunodeficiency syndrome (AIDS) epidemic. Excluding these two tumors, the overall risk of all other cancers in human immunodeficiency virus (HIV)-infected individuals is similar to that of the general population. However, varying levels of evidence link several additional neoplasms to HIV infection. The evidence is strongest for an association with Hodgkin's disease, with lower relative and absolute risks than for non-Hodgkin's lymphoma. Anogenital intraepithelial neoplasia also appears to be HIV associated, but increases of invasive disease are still uncertain for both cervical and anal cancers. Various studies have suggested associations with testicular seminoma, multiple myeloma, oral cancer, and melanoma, but the data are inconsistent. Leiomyosarcoma and benign leiomyomas have increased in incidence in HIV-infected children but are unusual in HIV-infected adults. Conjunctival carcinoma is seen in HIV-infected individuals in sub-Saharan Africa but it is uncommon in Western countries. Most other cancers do not seem to have increased incidences in HIV infection. The etiologic mechanisms of HIV-related cancer likely differ among these diverse cancers and do not globally increase cancer risk
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Cohen, S G
TI  - Asthma among the famous. Adb el-Kader [1808-1883], founder of the Algerian state
JO  - Allergy and Asthma Proceedings
PY  - 1997/01/01/
VL  - 18
IS  - 1
SP  - 50
EP  - 52
SN  - 10885412
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; Named Person: el-Kader. Database Contributor: MEDLINE. Database Contributor ID: 9162573. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9162573. Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 1; 
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Stevens, J
TI  - Brief psychoses: do they contribute to the good prognosis and equal prevalence of schizophrenia in developing countries
JO  - British Journal of Psychiatry
PY  - 1987/01/01/
VL  - 151
SP  - 393
EP  - 396
SN  - 00071250
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3427295. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3427295. Author Affiliation: National Institute of Mental Health, St Elizabeth's Hospital, Washington D.C. 20032 1; 
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Tawfik, H N
TI  - Carcinoma of the urinary bladder associated with schistosomiasis in Egypt: the possible causal relationship
JO  - Princess Takamatsu symposia
PY  - 1987/01/01/
VL  - 18
SP  - 197
EP  - 209
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3147281. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3147281. Author Affiliation: Department of Pathology, National Cancer Institute, Cairo University, Egypt 1; 
AB  - MEDLINE Abstract: Carcinoma of the urinary bladder is the most common malignancy in Egyptians. At the National Cancer Institute in Cairo, it accounts for 27.6% of all cancers--38.5% of cancers in the male and 11.3% in the female. This very high frequency is attributed to underlying schistosomiasis. The infection can lead to malignancy through local tissue damage, mechanical irritation, bilharzial toxins or through secondary bacterial infection. Bacterial products include nitrate reductase capable of synthesizing nitrosoamines and beta glucuronidase enzymes, active at pH 7. Through liver involvement and dysfunction, tryptophan metabolism is disturbed, with the excretion of carcinogenic metabolites. Vitamin A deficiency is responsible for the squamous metaplasia and the high frequency of squamous cell carcinoma observed in the bladder. The characteristic clinico-pathological features of cancer of the urinary bladder are outlined, mainly the occurrence at a young age, the male predominance, especially farmers, and the high association with schistosomiasis. The tumors are often first seen in an advanced stage, arising from the posterior bladder wall and vault. The trigone is only affected in 8.5% of the cases. Histologically, squamous cell carcinomas of low grade are the most frequent cell type. Lymph node involvement is low in spite of the advanced stage of the tumor. Therefore, the results of radical surgery are encouraging. The results of a special study correlating the above parameters with the intensity of ova deposition are presented. Patients with heavy infection at a slightly earlier age but other tumor parameters the same are similar to those of egg-negative cases. This study indicates that other factors also play a role in the induction of tumors that are enhanced by the schistosomal infection. In Fayoum Province, schistosomiasis is decreasing while bladder cancer is increasing. Urine cytology as a screening tool is effective in detecting early bladder cancer. Studies are now in progress to detect tumor associated antigens in sera and urine of patients
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Miller, L H
TI  - The challenge of malaria
JO  - Science
PY  - 1992/01/01/
VL  - 257
IS  - 5066
SP  - 36
EP  - 37
SN  - 00368075
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1621092. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1621092. Author Affiliation: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1; 
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Harris, C C
TI  - Chemical and physical carcinogenesis: advances and perspectives for the 1990s
JO  - Cancer Research
PY  - 1991/01/01/
VL  - 51
IS  - 18 Suppl
SP  - 5023s
EP  - 5044s
SN  - 00085472
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; Genome Sequence: Ha-ras; Ki-ras; Rb; aprt; dhfr; ras. Database Contributor: MEDLINE. Database Contributor ID: 1884379. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1884379. Author Affiliation: Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Carcinogenesis is a multistage process driven by carcinogen-induced genetic and epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal expansion as the result of activation of protooncogenes and/or inactivation of tumor suppressor genes. Therefore, the mutational spectra of chemical and physical carcinogens in these critical genes are of interest to define endogenous and exogenous mutational mechanisms. The p53 tumor suppressor gene is ideally suited for analysis of the mutational spectrum. Such an analysis has revealed evidence for both exogenous and endogenous molecular mechanisms of carcinogenesis. For example, an informative p53 mutational spectrum of frequent G----T transversions in codon 249 is found in hepatocellular carcinomas from either Qidong, People's Republic of China, or southern Africa. This observation links exposure to aflatoxin B1, a known cancer risk factor in these geographic regions, with a specific mutation in a cancer-related gene. Other studies indicate that abnormalities in genes controlling the cell cycle may cause genomic instability and increase the probability of neoplastic transformation. Finally, mechanistic understanding of carcinogenesis is leading to improved cancer risk assessment and to the identification of individuals at high cancer risk
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Murphy, P M
TI  - Chemokine receptors: structure, function and role in microbial pathogenesis
JO  - Cytokine and Growth Factor Reviews
PY  - 1996/01/01/
VL  - 7
IS  - 1
SP  - 47
EP  - 64
SN  - 13596101
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 8864354. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8864354. Author Affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 1; 
AB  - MEDLINE Abstract: The chemokine superfamily is composed of at least 20 different leukocyte chemoattractants that act by binding to a family of G protein-coupled receptors. Leukocyte subtypes respond preferentially to unique but overlapping subsets of chemokines as determined by the receptor distribution, yet the receptors appear to signal through a common Gi-type G protein. Since chemokines appear to play major roles in inflammatory pathology, their receptors may be good targets for developing leukocyte selective anti-inflammatory drugs. Two chemokine receptors, CC CKRS and ONCC, function pathologically as cell entry factors respectively for human immunodeficiency virus 1, the cause of AIDS, and Plasmodium vivax, the major cause of malaria
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Nussenblatt, R B
TI  - Clinical studies of Vogt-Koyanagi-Harada's disease at the National Eye Institute, NIH, USA
JO  - Japanese Journal of Ophthalmology
PY  - 1988/01/01/
VL  - 32
IS  - 3
SP  - 330
EP  - 333
SN  - 00215155
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3230719. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3230719. Author Affiliation: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: We have, in the recent past, seen 46 Vogt-Koyanagi-Harada's disease patients at the National Eye Institute. Most of these patients have been women, and a high percentage were Black-American or Hispanic. However, an interesting observation has been American Indian antecedents for a large number of these patients, whether they considered themselves Black or Caucasian. The visual acuities tended to be at the extremes of the vision chart. Patients with this disorder appear to have circulating autoantibodies to the retinal photoreceptor region, and these autoantibodies do not appear to be directed against the retinal S-antigen
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Harrington, M G
AU  - Kennedy, P G
TI  - The clinical use of cerebrospinal fluid studies in demyelinating neurological diseases
JO  - Postgraduate Medical Journal
PY  - 1987/01/01/
VL  - 63
IS  - 743
SP  - 735
EP  - 740
PB  - BMJ Publishing Group LTD
SN  - 00325473
N1  - Database Contributor: HEALTHLIT. Database Contributor ID: 1197997. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1197997. Author Affiliation: 1987 Year - Biochemical Genetics Section, National Institute of Mental Health, Bethesda, MD 20892, USA 1; 
AB  - HEALTHLIT Abstract: The clinical diagnosis of definite multiple sclerosis is supported by abnormalities in the cerebrospinal fluid: variable mild pleocytosis and elevation of total protein, moderately elevated total IgG in most patients, and the almost invariable presence of discrete immunoglobulins after electrophoresis, the oligoclonal bands. The oligoclonal bands are non-specific, and are seen in most diseases of the nervous system, but their temporal uniformity in each patient with multiple sclerosis is characteristic. Prognostically, patients with a single episode of optic neuritis or paraesthesia who have oligoclonal bands are more likely to develop multiple sclerosis than if the spinal fluid were normal. In the Guillain-Barré syndrome, the spinal fluid total protein is transiently elevated, with no pleocytosis. Oligoclonal bands are usually found in the acute phase and only persist in those patients with chronic or relapsing polyneuropathy
KW  - Diseases / Pathogens
KW  - Medical Science
KW  - Humans
KW  - Diseases / Pathogens
KW  - Medical Science
KW  - Humans
KW  - multiple sclerosis
KW  - cerebrospinal fluid
KW  - pleocytosis
KW  - oligoclonal bands
KW  - optic neuritis
KW  - paraesthesia
KW  - guillain-barre syndrome
KW  - polyneuropathy
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Alter, H J
TI  - Clinical, virological and epidemiological basis for the treatment of chronic non-A, non-B hepatitis
JO  - Journal of Hepatology
PY  - 1990/01/01/
VL  - 11 Su
IS  - 1
SP  - S19
EP  - S25
SN  - 01688278
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1964164. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1964164. Author Affiliation: Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Non-A, non-B hepatitis is the most common serious complication of blood transfusion and also occurs in a sporadic form whose routes of transmission are currently unknown. While generally mild in its acute presentation, non-A, non-B hepatitis frequently progresses to chronic hepatitis which may eventuate in cirrhosis and hepatocellular carcinoma. The disease is caused by a small, enveloped RNA virus now designated hepatitis C virus, which has similarities to the flaviviruses. Studies using the recently developed antibody assay have indicated that hepatitis C virus is the predominant agent of both transfusion-associated and sporadic non-A, non-B hepatitis. In 50-85% of transfusion-associated cases, a donor can be found who is positive for antibodies to the hepatitis C virus. Current data indicate that these antibodies are present in approx. 0.5% of blood donors in the United States and Europe, 1.5% in Japan and 6% in Africa, as well as in 60-80% of haemophiliacs and intravenous drug abusers and approx. 20% of dialysis patients. With changes in donor selection and transfusion practices, the incidence of transfusion-associated non-A, non-B hepatitis has declined from rates of 5-10% prior to 1985 to estimated current rates of 2-4%. The introduction of the anti-HCV test should effect an additional 50% reduction in transfusion-associated non-A, non-B hepatitis. In addition to these preventive measures, effective therapy now appears at hand in the form of alpha-interferon. The efficacy of other antiviral agents and the potential for combination therapies also need to be explored
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Komatsu, K.
AU  - Oeda, T.
AU  - Strott, C.A.
TI  - Cloning and sequence analysis of the 5'-flanking region of the estrogen sulfotransferase gene: steroid response elements and cell-specific nuclear DNA-binding proteins [Language: en]
JO  - Biochemical and Biophysical Research Communications
PY  - 1993/01/01/
VL  - 194
IS  - 3
SP  - 1297
EP  - 1304
SN  - 0006291X
AV  - Location: GB; Number: 9515839
N1  - Database Contributor: AGRIS. Database Contributor ID: GB9515839. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: GB9515839. Author Affiliation: Strott, C.A. : Section on Adrenal Cell Biology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 USA 1; 
KW  - guinea pigs
KW  - nucleotide sequence
KW  - enzymes
KW  - dna
KW  - proteins
KW  - oestrogens/ glucocorticoids
KW  - cobaye
KW  - sequence nucleique
KW  - enzyme
KW  - adn
KW  - proteine
KW  - oestrogene/ glucocorticoide
KW  - cobaya
KW  - secuencia nucleica
KW  - enzimas
KW  - proteinas
KW  - estrogenos/ glucocorticoides
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Knutsen, T
TI  - Cytogenetic changes in the progression of lymphoma
JO  - Leukemia and Lymphoma
PY  - 1998/01/01/
VL  - 31
IS  - 1-2
SP  - 1
EP  - 19
SN  - 10428194
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: turidk@Box-t.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9720711. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9720711. Author Affiliation: Cytogenetics Laboratory, Experimental Therapeutics Section Medicine Branch, NCI National Institutes of Health, Bethesda, MD, USA 1; 
AB  - MEDLINE Abstract: The study of chromosomal changes related to tumor progression in NHL is complicated by the various histologic classification systems and the lack of large serial studies comparing abnormalities at different disease stages. The T-cell lymphomas frequently involve rearrangements of the T-cell receptors and tumor progression is marked by a change from single cell aberrations and polyclonality in low grade disease to monoclonal formation, complex clones, polyploidy, and abnormalities of 1p, 6q, 7, and 13 in high grade T-NHL. In B-cell NHL, specific translocations and oncogene rearrangements are associated with specific NHL subtypes de novo; many of these translocations involve immunoglobulin genes, such as t(14;18) in follicular lymphoma, t(11;14) in MCL, t(3;14) in DLLC, and t(8;14) in Burkitt's lymphoma. Tumor progression is associated with secondary abnormalities which are generally not confined to a particular NHL subtype. Some abnormalities, such as those involving chromosomes 1, 6, and 17, >4-6 clonal markers/cell, and rearrangements of c-MYC and TP53, have prognostic significance while others, such as trisomies 7, 12, 18, and X, are associated with tumor progression but their influence on overall survival is uncertain
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Wynn, T A
TI  - The debate over the effector function of eosinophils in helminth infection: new evidence from studies on the regulation of vaccine immunity by IL-12
JO  - Instituto Oswaldo Cruz, Rio de Janeiro. Memorias
PY  - 1997/01/01/
VL  - 92 Su
IS  - 2
SP  - 105
EP  - 108
SN  - 00740276
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 187348-17-0. Database Contributor: MEDLINE. Database Contributor ID: 9698921. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9698921. Author Affiliation: Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 1; 
AB  - MEDLINE Abstract: The production of Th1-type cytokines is associated with strong cell-mediated immunity while Th2-type cytokines are typically involved in the generation of humoral immune responses. In mice vaccinated a single time (1X) with attenuated cercariae of Schistosoma mansoni, the immunity induced is highly dependent on CD4+ T cells and IFN-gamma. In contrast, mice vaccinated multiple times (3X) have decreased IFN-gamma expression, develop a more dominant Th2-type cytokine response as well as protective antibodies which can passively transfer immunity to naive recipients. Previously, we demonstrated the ability of IL-12, a potent IFN-gamma-inducing cytokine to enhance (1X) schistosome cell-mediated saline-treated mice demonstrated a 70 immunity when administered during the period of immunization. More recently, we asked what effects IL-12 would have on the development humoral-based immunity. While multiply-immunized/ saline-treated mice demonstrated a 70-80% reduction in parasite burden, 3X/IL-12-vaccinated animals displayed an even more striking > 90% reduction in challenge infection, with many mice in the later group demonstrating complete protection. Analysis of pulmonary cytokine mRNA responses demonstrated that control challenged mice elicited a dominant Th2-type response, 3X/saline-vaccinated produced a mixed Th1/Th2-type cytokine response, while 3X/IL-12-immunized animals displayed a dominant Th1-type response. The IL-12-treated group also showed a marked reduction in total serum IgE and tissue eosinophilia while SWAP-specific IgG2a and IgG2b Abs were elevated. Interestingly, animals vaccinated with IL-12 also showed a highly significant increase in total Ig titers specific for IrV, a known protective antigen. More importantly, 3X/IL-12 serum transferred significantly less protection. Nevertheless, animals vaccinated in the presence of IL-12 also develop macrophages with enhanced nitric oxide dependent killing activity against the parasites. Together, these observation suggest that IL-12, initially described as an adjuvant for cell-mediated immunity, may also be used as an adjuvant for promoting both humoral and cell-mediated protective responses
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Wynn, T A
TI  - Development of an antipathology vaccine for schistosomiasis
JO  - New York Academy of Sciences. Annals
PY  - 1996/01/01/
VL  - 797
SP  - 191
EP  - 195
SN  - 00778923
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 187348-17-0; 82115-62-6. Database Contributor: MEDLINE. Database Contributor ID: 8993362. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8993362. Author Affiliation: Immunobiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA 1; 
AB  - MEDLINE Abstract: The data presented here clearly demonstrate that IL-12 can act as an adjuvant, suppressing both granuloma formation and fibrosis induced after natural schistosome infection. Recently, we showed that IL-12 can increase protective immunity provided by an attenuated larval schistosome vaccine as well. In both cases the vaccines appear to suppress in large part the parasite-induced Th2 responses. Thus, the use of cytokines as adjuvants offers a rational approach for immunomodulation when the effector mechanism of a particular vaccine is known. Clearly, IL-12 has enormous potential for modulating the outcome of immunization and may have broad application in preventing a variety of different infectious diseases
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Zaghloul, M S
TI  - Distant metastasis from bilharzial bladder cancer
JO  - Cancer
PY  - 1996/01/01/
VL  - 77
IS  - 4
SP  - 743
EP  - 749
SN  - 0008543X
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8616767. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8616767. Author Affiliation: Radiotherapy Department, National Cancer Institute, Cairo, Egypt 1; 
AB  - MEDLINE Abstract: BACKGROUND: Distant metastasis is rarely described among bilharzial bladder cancer patients. However, with improved 5-year survival rates following adjuvant local therapy, distant metastasis is now reported with increasing frequency. METHODS: Three-hundred-fifty-seven bilharzial bladder cancer patients were treated at the National Cancer Institute in Cairo, Egypt, during the period 1981-1990. They were treated with either cystectomy alone, cystectomy preceded by a short course of preoperative radiotherapy (2000 cGy/5 fractions/1 week), or cystectomy followed by postoperative irradiation (5000 cGy/25 fractions/5 weeks or 3750 cGy/30 fractions/2 weeks). These patients were retrospectively analyzed. RESULTS: The overall 5-year actuarial rate of distant metastasis was 23% (95% confidence interval, 21-25%), which was essentially the same in the 3 therapeutic groups. Both univariate and multivariate analyses revealed that the independent risk factors for distant metastasis were pelvic lymph node involvement (P = 0.005), pathologic stage (P = 0.004), and histopathologic grade (P = 0.05). Histologic type and local pelvic recurrence appeared in the univariate analysis as working risk factors; however, they were proven by multivariate analysis to be dependent on other risk factors. Patients who had none of the independent risk factors had a lower rate of distant metastasis (II%) and a high local control rate (88%). Those who had more than one risk factor had high distant metastasis rate (51%) and low local control rate (41%), regardless of the therapeutic modality used. The identified independent risk factors determined both the distant metastasis and the local control rates. CONCLUSIONS: Unlike previous reports, this rigorous study of distant metastasis in bilharzial bladder cancer revealed an occurrence rate of 23%. This high rate was associated with pelvic lymph node involvement, pathologic stage, and histopathologic grade. Histologic type, local pelvic recurrence, or the addition of pre- or post-operative radiotherapy proved not to be independent risk factors
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AU  - Sheu, Y
TI  - Drug abuse and acquired immune deficiency syndrome
JO  - Psychiatry and Clinical Neurosciences
PY  - 1998/01/01/
VL  - 52 Su
EP  - 74
SN  - 13231316
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9895137. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9895137. Author Affiliation: Medical Affairs, Division of Clinical Research and Services, National Institute on Drug Abuse, Rockville, Maryland 20857, USA 1; 
AB  - MEDLINE Abstract: Acquired immune deficiency syndrome (AIDS) is a modern plague. The first sign of the disease was the appearance of Pneumocystis carinii and Kaposi's sarcoma among young homosexual patients. The virus transmission is from an infected individual to a susceptible host through blood-related, sexual, and perinatal routes. Exchange of body fluid occurs when sharing syringes, drugs, and drug paraphernalia. Although the largest number of people infected with human immunodeficiency virus (HIV) is in subSaharan Africa, the most rapid growth of HIV infection during the 1990s was seen in South-East Asia. Asia showed a steep increase from 1992. Given the experiences in Thailand, India and China, a similar spread of AIDS in other parts of Asia is possible. The risk behaviors that enable the spread of HIV are present in all Pacific Asian countries. Risk behaviors are considered to be the injection of illicit drugs, male patronage of prostitutes, high rates of sexually transmitted diseases, and low condom use
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AU  - Tawfik, M O
TI  - Egypt: status of cancer pain and palliative care
JO  - Journal of Pain and Symptom Management
PY  - 1993/01/01/
VL  - 8
IS  - 6
SP  - 409
EP  - 411
SN  - 08853924
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7525763. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7525763. Author Affiliation: Department of Algology, National Cancer Institute, Cairo University, Egypt 1; 
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AU  - Blot, W J
TI  - Esophageal cancer trends and risk factors
JO  - Seminars in Oncology
PY  - 1994/01/01/
VL  - 21
IS  - 4
SP  - 403
EP  - 410
SN  - 00937754
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8042037. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8042037. Author Affiliation: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Esophageal cancer displays unique epidemiologic features that distinguish it from all other malignancies. It shows marked geographic variation both internationally, with exceptionally high rates (some of the world's highest for any cancer) in limited areas of Asia, and nationally, with clustering of increased rates within the United States as well. However, the patterns are changing with rates of squamous cell carcinomas decreasing and adenocarcinomas increasing rapidly in several western countries. The causes of the clusters of squamous cell carcinomas in parts of Asia and Africa are not well known, but within the United States and other western countries, tobacco and alcohol consumption are the major determinants. Nutritional factors also may play a major role, with diets high in fresh fruits and vegetables consistently associated with reduced risks. The causes of the rapidly increasing rates of adenocarcinomas of the esophagus, and reasons or its occurrence primarily among white men, are enigmatic. Additional research on the etiology of this emerging cell type is warranted, and may provide information crucial to the development of readily implementable preventive strategies
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AU  - Miller, L H
TI  - Evolution of the human genome under selective pressure from malaria: applications for control
JO  - Parassitologia
PY  - 1999/01/01/
VL  - 41
IS  - 1-3
SP  - 77
EP  - 82
SN  - 00482951
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: lmiller@niaid.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 10697836. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10697836. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA 1; 
AB  - MEDLINE Abstract: Research on the molecular basis for resistance of humans to malaria has been vigorous during the last 10 years, with new discoveries and extension of work from previous decades. Much of the work has important implications both for understanding pathogenesis and for applications for control of disease
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AU  - Nutman, T B
TI  - Experimental infection of humans with filariae
JO  - Reviews of Infectious Diseases
PY  - 1991/01/01/
VL  - 13
IS  - 5
SP  - 1018
EP  - 1022
SN  - 01620886
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1962076. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1962076. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: This report summarizes the findings of the 17 published studies involving humans who have been experimentally infected with filarial parasites. Over the past 60 years, 45 individuals have been deliberately infected with Wuchereria bancrofti, Brugia malayi, Brugia pahangi, Loa loa, Mansonella perstans, Mansonella ozzardi, and/or Onchocerca volvulus. The findings from these experimental infections of humans have helped define microfilarial survival and periodicity within human hosts, the prepatent period for the causative agents of lymphatic filariasis, etiologic agents for particular clinical syndromes, immunologic and hematologic consequences of filarial infection, and the role of chemotherapeutic agents in the prevention and treatment of filarial infections
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AU  - James, S L
TI  - Experimental models of immunization against schistosomes: lessons for vaccine development
JO  - Immunological Investigations
PY  - 1992/01/01/
VL  - 21
IS  - 5
SP  - 477
EP  - 493
SN  - 08820139
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1428021. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1428021. Author Affiliation: Immunology and Cell Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Schistosomiasis is a debilitating, and sometimes deadly, parasitic infection that afflicts hundreds of millions of people living in developing countries. One of the best hopes for control of this disease is vaccine development. Studies on experimental models of attenuated vaccines have proven that high levels of protective immunity can be achieved. In these systems, resistance has been shown to be directed against the migrating larval stages of the parasite and to have both cellular and humoral components. Several candidate vaccine immunogens have been identified on the basis of antibody reactivity. However, the level of protection induced by immunization with nonliving vaccines has at yet not approached the level observed with attenuated infection. Current challenges to vaccine development include identification of protective T cell immunogens, determination of ways to strengthen the immunogenicity of isolated parasite antigens, and development of methodologies to selectively stimulate protective, as opposed to ineffective or even detrimental, immune responses
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AU  - Berzofsky, J A
TI  - Features of T-cell recognition and antigen structure useful in the design of vaccines to elicit T-cell immunity
JO  - Vaccine
PY  - 1988/01/01/
VL  - 6
IS  - 2
SP  - 89
EP  - 93
SN  - 0264410X
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2455388. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2455388. Author Affiliation: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: In contrast to antibodies, T lymphocytes tend to recognize a limited number of immunodominant antigenic sites on a protein antigen. Therefore, the effective design of synthetic or recombinant fragment vaccines would be better approached if these sites could be identified. From studies of the processing and genetically restricted presentation of the model protein antigen myoglobin to murine T cells, certain general principles have emerged which should be useful in this endeavour. The immunodominant sites for helper T cells in model proteins tend to be regions which can fold as alpha-helices and, in particular, helices which are amphipathic, i.e. which have a hydrophobic side and a hydrophilic side separated in space. These two sides may serve to interact with the major histocompatibility molecule on the antigen-presenting cell and with the T-cell receptor, respectively. A computer algorithm has been developed to search for such sites in protein sequences and it has been applied to two proteins of interest for vaccine development, the circumsporozoite protein of Plasmodium falciparum malaria and the envelope protein of the AIDS virus (HIV). Corresponding peptides were synthesized and shown to induce helper and/or proliferative T-cell immunity
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AU  - Ottesen, E A
TI  - Filarial infections
JO  - Infectious Disease Clinics of North America
PY  - 1993/01/01/
VL  - 7
IS  - 3
SP  - 619
EP  - 633
SN  - 08915520
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 70288-86-7; V867Q8X3ZD. Database Contributor: MEDLINE. Database Contributor ID: 8254163. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8254163. Author Affiliation: Clinical Parasitology Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: The seven filarial parasites of humans infect over 100 million people worldwide. These parasites are long lived, with adults living an average of 10 to 15 years and the microfilaria, probably 6 to 12 months. Importantly, as with most other helminth parasites, there is no replication of the adult parasite within the human host so that the extent of infection (that is, the number of adult worms one has) never increases after one leaves an endemic region and ceases to be exposed to the insect-borne infective larvae. This article will discuss the diagnosis and treatment of filarial infections, as well as some recent clinical advances
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AU  - Ottesen, E A
TI  - Filariasis now
JO  - American Journal of Tropical Medicine and Hygiene
PY  - 1989/01/01/
VL  - 41
IS  - 3 Suppl
SP  - 9
EP  - 17
SN  - 00029637
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2679166. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2679166. Author Affiliation: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 1; 
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AU  - Gwadz, R W
TI  - Genetic approaches to malaria control: how long the road
JO  - American Journal of Tropical Medicine and Hygiene
PY  - 1994/01/01/
VL  - 50
IS  - 6 Suppl
SP  - 116
EP  - 125
SN  - 00029637
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7912907. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7912907. Author Affiliation: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: Malaria control schemes based on the yet untested concept of replacing vector populations with mosquitoes of the same species unable to transmit the parasite offer one more means of attacking this important public health problem. Research is underway in several laboratories aimed at defining factors that can act to interrupt the development of the malaria parasite in the mosquito host, the genetic basis for such refractory mechanisms, methods for introducing genes coding for refractory mechanisms into the mosquito genome, and methods for replacing vector populations in the field. The complexities of such an undertaking are many and varied, but the potential impact of a successful replacement strategy on the epidemiology of malaria in the target area could be significant
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AU  - Yanagihara, R
TI  - Hantavirus infection in the United States: epizootiology and epidemiology
JO  - Reviews of Infectious Diseases
PY  - 1990/01/01/
VL  - 12
IS  - 3
SP  - 449
EP  - 457
SN  - 01620886
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1972804. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1972804. Author Affiliation: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Multiple species of murid and arvicolid (microtine) rodents serve as the reservoir hosts of hantaviruses, the etiologic agents of hemorrhagic fever with renal syndrome. Three antigenically distinct hantaviruses have been isolated from Rattus norvegicus, Mus musculus, and Microtus pennsylvanicus captured in the United States, and serologic evidence of a hantavirus enzootic has been found in several other indigenous rodent species. In residential districts of port cities such as Baltimore, nearly 50% of Norway rats are infected with viruses that are serologically indistinguishable from disease-causing Hantavirus strains isolated from rats in the Far East. Despite the widespread distribution of Hantavirus-infected rodents, confirmed cases of hemorrhagic fever with renal syndrome have not been recognized in the United States. Moreover, the overall risk of hantavirus infection in humans in the United States is low, even among individuals who have frequent exposure to commensal and wild rodents. Studies are needed to define the clinical spectrum of hantavirus infection in humans in the United States
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AU  - Tabor, E
TI  - Hepatocellular carcinoma: possible etiologies in patients without serologic evidence of hepatitis B virus infection
JO  - Journal of Medical Virology
PY  - 1989/01/01/
VL  - 27
IS  - 1
SP  - 1
EP  - 6
SN  - 01466615
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 9N2N2Y55MH. Database Contributor: MEDLINE. Database Contributor ID: 2537873. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2537873. Author Affiliation: Biological Carcinogenesis Program, National Cancer Institute, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Although hepatitis B virus (HBV) has been closely associated with the development of hepatocellular carcinoma (HCC), no serologic markers of HBV can be found in up to 11% of HCC patients in developing countries and up to 68% of HCC patients in industrialized countries. Despite the absence of HBV serologic markers in these HCC patients, HBV DNA sequences have been found to be integrated into HCC DNA in 13-100% of these patients, indicating a possible role of HBV in the etiology of their HCC. Although six patients with chronic non-A, non-B hepatitis virus infection who were followed have been documented to develop HCC, it is not known whether the non-A, non-B hepatitis viruses cause or contribute to the development of HCC in some HCC patients without HBV serologic markers. Ethanol, cigarette smoking, oral contraceptives, and aflatoxin also have been suggested as possible etiologies and should be studied further. Suggested etiologies that are not supported by the published data include alpha-1-antitrypsin deficiency and schistosomiasis
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AU  - Arya, S K
TI  - Human and simian immunodeficiency retroviruses: activation and differential transactivation of gene expression
JO  - AIDS Research and Human Retroviruses
PY  - 1988/01/01/
VL  - 4
IS  - 3
SP  - 175
EP  - 186
SN  - 08892229
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; NI40JAQ945. Database Contributor: MEDLINE. Database Contributor ID: 2840105. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2840105. Author Affiliation: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: New West African human immunodeficiency viruses (HIV-2s) and simian immunodeficiency virus (SIV) contain functional transactivator (tat) gene and tat response elements. Their long terminal repeats (LTR) and tat genes are more related among themselves than to HIV-1 LTR and tat gene. The viral gene expression of HIV-2 as well as SIV can be stimulated by T cell activators, such as mitogens and phorbol esters. HIV-2 and SIV display a much broader transactivation response specificity than does HIV-1. The LTR-directed gene expression of HIV-2/SIV is not only transactivated by their own tat gene and by HIV-1 tat gene but also by factors in human T cell leukemia/lymphoma virus type I (HTLV-I) and simian virus 40 (SV40) infected cells, involving HTLV-I tat gene and SV40 T antigens, respectively. HIV-1 LTR-directed gene expression is much less transactivated by HIV-2/SIV tat genes and by factors in HTLV-I- and SV40-infected cells. Immune activation and heterologous transactivation of the LTR-directed gene expression may be relevant to the latency of virus infection and progression toward the acquired immunodeficiency syndrome (AIDS)
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AU  - Yanagihara, R
TI  - Human T-cell lymphotropic virus type I infection and disease in the Pacific basin
JO  - Human Biology
PY  - 1992/01/01/
VL  - 64
IS  - 6
SP  - 843
EP  - 854
SN  - 00187143
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1427742. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1427742. Author Affiliation: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Human T-cell lymphotropic virus type I (HTLV-I), the cause of adult T-cell leukemia/lymphoma (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), is widespread in the Pacific basin. Modes of virus transmission include blood transfusion (and intravenous drug use), breast milk, and sexual intercourse. High prevalences of HTLV-I infection and disease occur among the inhabitants of southwestern Japan and among first- and second-generation (issei and nisei) Japanese-Americans in the Hawaiian Islands. Other Pacific populations with high prevalences of HTLV-I infection include several remote groups in West New Guinea, Papua New Guinea, the Solomon Islands, and Vanuatu, which have had no contact with Japanese or Africans. By contrast, Micronesian and Polynesian populations, even those with prolonged contact with Japanese, exhibit low prevalences or no evidence of HTLV-I infection. Low prevalences of infection are also found in Australia, except among some aboriginal populations. Changing patterns of HTLV-I infection and disease are no better exemplified than in Japan, where striking reductions in transfusion-acquired infection and subsequent development of HAM/TSP have followed the institution of nationwide screening of blood donors for HTLV-I infection. Furthermore, virus transmission from mother to infant by means of infected breast milk has been markedly curtailed in HTLV-I-hyperendemic regions in Japan by interrupting the practice of breast feeding by HTLV-I-infected mothers. The next frontier of HTLV-I research is in Melanesia, where highly divergent sequence variants of HTLV-I have been discovered
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AU  - Wynn, T A
TI  - Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology
JO  - Microbes and Infection
PY  - 1999/01/01/
VL  - 1
IS  - 7
SP  - 525
EP  - 534
SN  - 12864579
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 10603569. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10603569. Author Affiliation: The Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 1; 
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AU  - Kaslow, D C
TI  - Immunogenicity of Plasmodium falciparum sexual stage antigens: implications for the design of a transmission blocking vaccine
JO  - Immunology Letters
PY  - 1990/01/01/
VL  - 25
IS  - 1-3
SP  - 83
EP  - 86
SN  - 01652478
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1704352. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1704352. Author Affiliation: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Immunogenicity of sexual stage antigens and boosting of transmission blocking antibodies following a natural infection are two critical factors in the design of an effective, subunit vaccine to block the transmission of malaria from man to mosquito. Immunogenicity and boosting are both T cell-dependent. Antigens, such as the 230-kDa, the 48/45-kDa, and the 40/10-kDa, expressed early in the extracellular forms of the sexual stage of Plasmodium falciparum, have limited immunogenicity in humans and in mice. In contrast, Pfs25, expressed predominantly in zygotes and ookinetes, has widespread immunogenicity in mice. Pfs25 expressed by a recombinant vaccinia virus (vSIDK) is also widely immunogenic in mice, and induces transmission blocking antibodies following multiple inoculations with vSIDK. The implications of these immunogenicity data are discussed relative to the design of an effective transmission blocking vaccine
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AU  - Levine, P H
TI  - Immunologic markers for Epstein-Barr virus in the control of nasopharyngeal carcinoma and Burkitt lymphoma
JO  - Cancer detection and prevention. Supplement: official publication of the International Society for Preventive Oncology, Inc
PY  - 1987/01/01/
VL  - 1
SP  - 217
EP  - 223
SN  - 10436995
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2826001. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2826001. Author Affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Immunologic assays have been instrumental in implicating the Epstein-Barr virus (EBV) as an etiologic factor in nasopharyngeal carcinoma (NPC) and Burkitt lymphoma (BL). In this report, the importance of a variety of specific assays to detect EBV in tumor biopsies and antibodies to EBV antigens in serum from patients with NPC and BL is reviewed. In both NPC and BL, the involvement of EBV appears to differ in various geographic locations. Therefore, it is necessary to be able to interpret the available immunologic laboratory tests to know if a specific patient has "EBV-associated" or "non-EBV-associated" cancer. Such information is not only relevant to etiologic studies in different populations but to identifying individuals at high risk for NPC and BL, to monitoring their response to therapy, and to determining the most appropriate forms of therapy
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Jordan, W S., Jr
TI  - Impediments to the development of additional vaccines: vaccines against important diseases that will not be available in the next decade
JO  - Reviews of Infectious Diseases
PY  - 1989/01/01/
VL  - 11 Su
IS  - 3
EP  - 1495
SN  - 01620886
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 2669104. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2669104. Author Affiliation: National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: The availability of new biotechnologies has led to the prediction that new or improved vaccines can be developed for 27 diseases within the next decade. The reasons why such optimism cannot be extended to the availability of vaccines for many other infectious diseases are considered by reviewing the steps in vaccine development, from identification of the etiologic agent to construction of attenuated or inactivated vaccines. Impediments to development may exist or arise at any point in this pathway (e.g., multiplicity of serotypes, inability to cultivate the pathogen, multistage life cycles with multiple antigens, unpredictability of epidemics, inadequate knowledge of pathogenesis and immunity, fear of gene splicing, need for an adjuvant, and lack of profitability). Diseases for which vaccines are not likely to be available in the next decade include trachoma, onchocerciasis, pneumonia due to Legionella and to mycoplasmas, amebiasis and giardiasis, schistosomiasis, syphilis, chlamydial urethritis, trypanosomiasis, leishmaniasis, and filariasis, and non-A, non-B hepatitis
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Haverkos, H W
TI  - Infectious diseases and drug abuse. Prevention and treatment in the drug abuse treatment system
JO  - Journal of Substance Abuse Treatment
PY  - 1991/01/01/
VL  - 8
IS  - 4
SP  - 269
EP  - 275
SN  - 07405472
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1787552. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1787552. Author Affiliation: Division of Clinical Research, National Institute on Drug Abuse, United States Public Health Service, Rockville, Maryland 20857 1; 
AB  - MEDLINE Abstract: Several communicable infectious diseases, including AIDS, hepatitis B infection, gonorrhea, syphilis, and tuberculosis, are increasing among drug abusers. Drug abuse treatment programs may be ideal sites to identify those infections and initiate and maintain appropriate medical management. This paper reviews the epidemiology of those infections among drug abusers in the USA, presents rudimentary aspects of medical management of selected infectious diseases, and discusses the need to integrate infectious diseases, drug abuse treatment, and public health approaches if we are to reverse, or at least stabilize, the trends of those diseases
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Quinn, T C
TI  - Interactions of the human immunodeficiency virus and tuberculosis and the implications for BCG vaccination
JO  - Reviews of Infectious Diseases
PY  - 1989/01/01/
VL  - 11 Su
IS  - 2
EP  - 17
SN  - 01620886
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 2652254. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2652254. Author Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: AIDS has become a global epidemic, with greater than 100,000 cases officially reported in 140 countries and an estimated 5-10 million asymptomatic carriers of the human immunodeficiency virus (HIV), the etiologic agent of AIDS. With an increase in HIV infection in some developing countries, there has been a resurgence in tuberculosis, and concern has been raised about the indications, efficacy, and safety of bacille Calmette-Guérin (BCG) vaccination. Anecdotal reports of local reactions and disseminated disease have been described in HIV-infected children and adults. Ten HIV-infected infants, who received BCG vaccination within 2 months of birth, developed local lymphadenitis at 4-15 months. However, in one preliminary survey in Zaire, the rates of local lymphadenitis were equal in HIV-infected and HIV-uninfected children, and no dissemination has been observed to date. Until further information is known, BCG vaccinations should not be given to symptomatic HIV-infected individuals and should only be given to HIV-infected children who are asymptomatic and who reside in areas where tuberculosis is highly endemic and where the risk of tuberculosis may outweigh the potential complications of BCG immunization
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Seidman, M M
TI  - Intermolecular homologous recombination between transfected sequences in mammalian cells is primarily nonconservative
JO  - Molecular and Cellular Biology
PY  - 1987/01/01/
VL  - 7
IS  - 10
SP  - 3561
EP  - 3565
SN  - 02707306
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3683393. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3683393. Author Affiliation: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Intermolecular recombination in mammalian cells was studied by coinfecting African green monkey cells in culture with two shuttle vector plasmids, each carrying an incomplete but overlapping portion of the gene for neomycin resistance. The region of homology between the two plasmids was about 0.6 kilobases. Recombination between the homology regions could reconstruct the neomycin resistance gene, which was monitored by analysis of progeny plasmids in bacteria. The individual plasmids carried additional markers which, in combination with restriction analysis, allowed the determination of the frequency of formation of the heterodimeric plasmid which would be formed in a conservative recombination reaction between the homologous sequences. Reconstruction of the neomycin resistance gene was readily observed, but only 1 to 2% of the neomycin resistance plasmids had the structure of the conservative heterodimer. Treatment of the plasmids which enhanced the frequency of the neomycin resistance gene reconstruction reaction did not significantly increase the relative frequency of conservative product plasmids. The results support nonconservative models for recombination of these sequences
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Cohen, L K
TI  - Leadership role of dental associations: oral health promotion
JO  - International Dental Journal
PY  - 1990/01/01/
VL  - 40
IS  - 1
SP  - 48
EP  - 53
SN  - 00206539
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2407662. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2407662. Author Affiliation: Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: 'Promoting Oral Health: Guidelines for Dental Associations' is the product of Working Group 3 on Oral Health Promotion of the Commission on Oral Health, Research and Epidemiology of the FDI. This paper describes the guidelines document, its rationale and its potential utility. An organized planned sequence of activities, including policy formation and dissemination, planning group structure and function, information gathering, goal setting, strategic planning of objectives and interventions, implementation as well as monitoring and evaluation, are reviewed. Relevant to both industrialized and developing countries, these oral health promotion guidelines can be used to develop programmes to demonstrate the benefit of self-care and appropriate demand for dental services
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Magrath, I T
TI  - Malignant non-Hodgkin's lymphomas in children
JO  - Hematology - Oncology Clinics of North America
PY  - 1987/01/01/
VL  - 1
IS  - 4
SP  - 577
EP  - 602
SN  - 08898588
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3323174. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3323174. Author Affiliation: Pediatric Branch, National Cancer Institute, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: The spectrum of non-Hodgkin's lymphomas (NHL) that occurs in children differs markedly from that in adults. This is probably a consequence of differences in the proportions of precursor and mature lymphoid cells in the immune systems of children and adults, and the greater emphasis on the development of an immunologic repertoire in the child. Childhood NHL can be classified into three main types based on histology, all of them diffuse: lymphoblastic, small noncleaved cell, and large cell. The majority of lymphoblastic lymphomas are of immature T cell (thymocyte) origin, although a few have a B cell precursor phenotype. All express the enzyme terminal transferase. Small noncleaved lymphomas express B cell characteristics, as do the majority do the majority of large cell lymphomas, although a small proportion of the latter express T cell characteristics. Very few are of true histiocytic origin. Little is known of the epidemiology of lymphoblastic and large cell lymphomas. However, using histology as a diagnostic criterion, both occur throughout the world and occur primarily, as do all childhood NHL, in the first two decades of life. There appear to be at least two types of small noncleaved cell lymphomas, both of which are associated with specific chromosomal translocations. An endemic form occurs at high frequency in equatorial Africa, and a sporadic form occurs at low frequency throughout the world. The endemic tumor is associated with the Epstein-Barr virus, it has a high incidence of jaw tumors, and has a breakpoint on chromosome 8 that is usually some distance upstream of the c-myc oncogene. The sporadic tumor is only occasionally associated with EBV, it often involves the bone marrow, particularly at relapse, and has a breakpoint on chromosome 8 that is usually very close to or within the c-myc oncogene. Childhood NHL is rarely truly localized, and treatment regimens are always based on chemotherapy. There is no evidence that radiation is beneficial when modern combination drug regimens are employed as the primary therapeutic modality. Prophylactic treatment to the central nervous system is recommended in nearly all patients, and intrathecal drugs, usually supplemented by some form of high-dose or intermediate-dose methotrexate, appear to represent adequate prophylaxis to the CNS. The most effective regimens result in cure in almost all patients who have limited overt disease, and in a high proportion (50 to 75 per cent) of patients w...
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Brossi A
TI  - Mammalian Alkaloids: Conversions of Tetrahydroisoquinoline-1-carboxylic Acids Derived from Dopamine
JO  - Planta Medica
PY  - 1991/01/01/
VL  - 57
IS  - 7
SP  - 100
EP  - 193
SN  - 00320943
N1  - Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-017369. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-017369. Author Affiliation: Natural products Section, Laboratory of structural Biology, NIDDK, National Institutes of Health, Bethesda. Maryland 20392, U.S.A. 9Arnold Brossi) 1; 
AB  - ALNAP Abstract: Racemic and optically active mammalian 6,7-dihydroxy-l,2,3.4-tetrahydroisoquinoline-l-carb- oxylic acids derived from dopamine, and quinonemeth- ides obtained from them by oxidative decarboxylation at physiological pH 7-9, are methylated by S-adenosyl-L- methionine in the presence of catechol-O-methyl-trans- ferase in vitro exclusively at the OH-group at C- 7. It can, therefore, be stated that these acids are unlikely inter- mediates in the biosynthesis ofisoquinolines en route to morphine. Enantiospecific and regioselective O-methy- lations observed with (S)- and (R)-norcoclaurines, lead- ing in the (S)-series predominantly to compounds methylated at the hydroxy group at C-6, and in the (R)- series to isomers methylated at the hydroxy group at C- 7, respectively, are in full accord with similar reactions oc- curring in the plant biosynthesis of morphine. Since the same methylation pattern is ascertained in reactions catalyzed by mammalian enzymes, it is suggested that mammals might be capable of synthesizing morphine from the same isoquinoline precursors
KW  - USA
KW  - USA
KW  - acid
KW  - alkaloid
KW  - Alkaloids
KW  - biology
KW  - biosynthesis
KW  - compound
KW  - compounds
KW  - dopamine
KW  - enzyme
KW  - enzymes
KW  - health
KW  - in vitro
KW  - isomer
KW  - isomers
KW  - isoquinoline
KW  - laboratory
KW  - Lead
KW  - mammalian
KW  - Mammals
KW  - methionine
KW  - methylation
KW  - morphine
KW  - Natural Product
KW  - natural products
KW  - Obtained
KW  - PH
KW  - physiological
KW  - plant
KW  - Precursor
KW  - precursors
KW  - products
KW  - regioselective
KW  - USA
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Magrath, I T
TI  - Management of high-grade lymphomas
JO  - Oncology
PY  - 1998/01/01/
VL  - 12
IS  - 10 Suppl 8
SP  - 40
EP  - 48
SN  - 08909091
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9830632. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9830632. Author Affiliation: Lymphoma Biology Section, National Cancer Institute, Bethesda, Maryland, USA 1; 
AB  - MEDLINE Abstract: High-grade non-Hodgkin's lymphomas generally refer to immunoblastic lymphoma, lymphoblastic lymphoma, and small-noncleaved-cell lymphoma, three histological subtypes that were associated with the worst prognosis at the time of categorization 16 years ago in the Working Formulation for Clinical Usage. Small-noncleaved-cell lymphoma was classified further into Burkitt's lymphoma and non-Burkitt's lymphoma. The treatment of high-grade lymphomas in adults remains somewhat unfavorable today. In children, however, survival rates of 80% to 90% are being achieved with intensive short duration protocols. In this article, the management of Burkitt, Burkitt-like, and lymphoblastic lymphomas is discussed as is the possibility of improved survival in adults using treatment strategies developed for pediatric patients
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Berzofsky, J A
TI  - Mechanisms of immunodominance in T-cell recognition, with applications to vaccine design
JO  - Princess Takamatsu symposia
PY  - 1988/01/01/
VL  - 19
SP  - 161
EP  - 177
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2479631. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2479631. Author Affiliation: Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Immunodominant T-cell antigenic sites can so dominate a response that their presence leads to high responsiveness and their absence to low responsiveness. Therefore, it is important to locate such sites for vaccine development. Factors that lead to immunodominance include features extrinsic to the structure of the site itself, such as the major histocompatibility complex (MHC) molecules of the host and the types of fragments produced by processing of the protein antigen before the T cell sees it. They also include factors intrinsic to the structure of the T-cell site, that determine a repertoire of potential immunodominant sites from which the extrinsic factors select a subset that will be immunodominant in a given individual. We have focused on one of these intrinsic factors, helical amphipathicity, that we have found to be a common feature among both helper and cytotoxic T-cell antigenic sites, suggesting that the same physical principles apply to sites seen in association with class I and class II MHC molecules. We have used this feature to locate immunodominant epitopes on the circumsporozoite protein of the Plasmodium falciparum malaria parasite and the envelope protein of the AIDS virus. Both helper and cytotoxic T-cell epitopes were identified. At least in the case of the helper T-cell sites, it was striking that the same sites in both the malaria and AIDS proteins studied that were immunodominant in the mouse were also immunodominant in the human, an indication that the same principles apply across species, and that the animal model will be useful for identifying sites to be used in vaccines for humans. These sites have been coupled with neutralizing antibody sites to produce artificial constructs that can elicit antibodies. It is hoped that the rational design of more complex versions of these artificial constructs will produce vaccines that are more effective than the natural pathogen proteins used in subunit vaccines, since such pathogen protein antigens have been selected through evolution to evade the immune system, not to optimize immunogenicity
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Berzofsky, J A
TI  - Mechanisms of T cell recognition with application to vaccine design
JO  - Molecular Immunology
PY  - 1991/01/01/
VL  - 28
IS  - 3
SP  - 217
EP  - 223
SN  - 01615890
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1708102. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1708102. Author Affiliation: Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Both helper and cytotoxic T lymphocytes generally recognize protein antigens not in their intact form, as antibodies do, but on the surface of another cell, after "processing" by that cell to unfold or cleave the protein into fragments and after association of the processed antigen with major histocompatibility complex (MHC) molecules on that cell. This complex process leads to immunodominance of certain segments from the protein, which depends not only on structural features intrinsic to the antigenic segment itself, but also on antigen processing and on the structure of the MHC molecules of the responding individual. We have explored all three of these factors, including the enzymes involved in processing, the way peptides bind to MHC molecules, and structural features such as helical amphipathicity that seem to favour T cell recognition. We have used this information to locate and characterize antigenic sites of proteins of interest for vaccine development, including proteins from the malaria parasite and the AIDS virus, HIV. For HIV, we have identified both helper and cytotoxic T cell sites, coupled a helper site to a B cell site to produce a synthetic immunogen that elicits neutralizing antibodies, and studied the effect of viral sequence variation on cytotoxic T cell recognition and binding of the immunodominant peptide to MHC molecules. This information suggests strategies for the rational design of synthetic or recombinant vaccines
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
AU  - Hallock, Y.F.
AU  - Manfredi, K.P.
AU  - Dai, J.R.
AU  - Cardellina, J.H. II.
AU  - Gulakowski, R.J.
AU  - McMahon, J.B.
AU  - Schaffer, M.
AU  - Stahl, M.
AU  - Gulden, K.P.
AU  - Bringmann, G.
TI  - Michellamines D-F, new HIV inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupenis [Language: en]
JO  - Journal of Natural Products
PY  - 1997/07/01/
VL  - 60
IS  - 7
SP  - 677
EP  - 683
SN  - 01633864
AV  - Location: *US (DNAL 442.8 L77); Number: 9741396
N1  - Database Contributor: AGRIS. Database Contributor ID: US9741396. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9741396. Author Affiliation: Hallock, Y.F. : National Cancer Institute, Frederick, MD 1; 
KW  - cameroon
KW  - drug plants
KW  - leaves
KW  - chemical composition
KW  - quinoline alkaloids
KW  - spectrometry
KW  - chemical structure
KW  - chemistry
KW  - antiviral agents
KW  - mankind
KW  - herpetoviridae
KW  - antiprotozoal agents
KW  - cameroun
KW  - plante medicinale
KW  - feuille
KW  - composition chimique
KW  - alcaloide quinolique
KW  - spectrometrie
KW  - structure chimique
KW  - chimie
KW  - antiviral
KW  - genre humain
KW  - antiprotozoaire
KW  - camerun
KW  - plantas medicinales
KW  - hojas
KW  - composicion quimica
KW  - alcaloides de la quinolina
KW  - espectrometria
KW  - estructura quimica
KW  - quimica
KW  - viricidas
KW  - genero humano
KW  - medicamentos contra protozoarios
KW  - spectral analysis
KW  - stereochemistry
KW  - human immunodeficiency virus
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Murphy, P M
TI  - The molecular biology of leukocyte chemoattractant receptors
JO  - Annual Review of Immunology
PY  - 1994/01/01/
VL  - 12
SP  - 593
EP  - 633
SN  - 07320582
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; EC Number: 3.6.1.-. Database Contributor: MEDLINE. Database Contributor ID: 8011292. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8011292. Author Affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Leukocytes migrate from the blood to sites of inflammation in response to locally produced chemoattractants that activate specific cell surface receptors. The primary structures of leukocyte receptors for N-formyl peptides, C5a, platelet-activating factor, and 8 of the 18 known human chemokines (interleukin-8 and related molecules) have been deduced from cloned cDNAs. All of these are seven-transmembrane-domain rhodopsin-like G protein-coupled receptors. Biochemical and molecular genetic analysis of the chemoattractant receptors indicates that the chemoattractants may have both broadly overlapping as well as specialized roles in the regulation of acute and chronic inflammation. Interestingly, the chemokine receptors have functional homologues in human cytomegalovirus and Herpesvirus saimiri. Moreover, the Duffy antigen, which mediates invasion of erythrocytes by Plasmodium vivax, a major cause of malaria, is also a chemokine binding protein. These surprising developments suggest that in addition to leukocyte-mediated inflammation, the chemokines may also be involved in erythrocyte function and, through molecular mimicry, in microbial pathogenesis
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Wellems, T E
TI  - Molecular genetics of drug resistance in Plasmodium falciparum malaria
JO  - Parasitology Today
PY  - 1991/01/01/
VL  - 7
IS  - 5
SP  - 110
EP  - 112
SN  - 01694758
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 15463460. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15463460. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 1; 
AB  - MEDLINE Abstract: Resistance to dihydro folate reductase inhibitors and resistance to chloroquine have been mapped to single genetic loci in Plasmodium falciparum. Specific point mutations in the dihydro folate reductase gene confer different degrees of resistance to two dihydro folate inhibitors, cycloguanil and pyrimethamine, depending on the positions of the mutations and the residues involved. The chloroquine resistance locus has been mapped to a 400 kilobase (kb) segment of chromosome 7 in a P. falciparum cross. Identification and characterization of genes within this segment should lead to an understanding of the rapid drug efflux mechanism responsible for chloroquine resistance
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Quinn, T C
TI  - Molecular variants of HIV-1 and their impact on vaccine development
JO  - International Journal of S T D & AIDS
PY  - 1998/01/01/
VL  - 9 Su
IS  - 1
SP  - 2
EP  - 2
SN  - 09564624
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 9874106. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9874106. Author Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA 1; 
AB  - MEDLINE Abstract: The global HIV pandemic is heterogenous and dynamic, and comprised of many subepidemics in different geographic locations and populations, each with distinctive features such as risk factors for transmission, clinical presentation of disease, and viral subtypes in circulation.  The genetic sequencing of HIV isolates has identified 2 major groups of HIV-1 designated group M (main) and group O (outlier).  10 different subtypes have been documented within the M group, subtypes A through J, comprising more than 95% of all HIV infections worldwide.  Group O viruses have not been subtyped and are of limited distribution, found mainly in west Africa and with sporadic reports in Europe and the US.  HIV-1 group M viruses have been the most intensely studied due to their global prevalence, with the best characterized subtype being subtype B, the predominant subtype in Europe and North America.  The capacity of HIV subtypes to recombine allows rapid and marked genetic change.  The greatest genetic variation in HIV-1 has been detected in central Africa, the area with the greatest density and duration of infection.  Subtype C has the greatest frequency of any subtype globally, with epidemics in South Africa, East Africa, and India.  The diverse molecular variation in the HIV genome among viral subtypes presents an obstacle to the development of an effective vaccine.  The need to explore the development of both envelope-based and multi-gene-based vaccines is noted
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AU  - Hayunga, E G
TI  - Morphological adaptations of intestinal helminths
JO  - Journal of Parasitology
PY  - 1991/01/01/
VL  - 77
IS  - 6
SP  - 865
EP  - 873
SN  - 00223395
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1779289. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1779289. Author Affiliation: Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Nematodes, trematodes, cestodes, and acanthocephalans each have become adapted in different ways to the microenvironment of the vertebrate intestine. Life in this specialized habitat affords parasites a reliable source of nutrients, a relatively homeostatic environment, and protection from predators but, in exchange for these advantages, presents the special challenges of exposure to digestive enzymes, normal peristalsis, and host immune response to infection. Logically, the surface of the parasite should be the first part of the organism to encounter such challenges, and, for this reason, any response or reaction by the parasite is expected to be manifested at the parasite-host interface. Morphological adaptations of intestinal helminths to their microenvironment include modification of the tegumental surface that affords protection and increases absorptive surface area, development of specialized attachment organs, and, in some cases, complete loss of their own internal digestive system. Representative examples of such adaptations by helminths are described and discussed in terms of the parasite's nutritional requirements, site selection, and host specificity, and the possibility is suggested that some helminths may have adapted in ways that exploit host defensive mechanisms for their own benefit
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ER  - 

AU  - Rigau-Pérez, J G
TI  - Mosquito caused death: the yellow fever epidemics in San Juan of Puerto Rico 1804-1805
T2  - Muerte por mosquito: la epidemia de fiebre amarilla en San Juan de Puerto Rico 1804-1805
JO  - Asociacion Medica de Puerto Rico. Boletin
PY  - 1991/01/01/
VL  - 83
IS  - 2
SP  - 58
EP  - 60
SN  - 00044849
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2043230. Database Subset: AFRICAN HEALTHLINE. Language: Spanish. Accession Number: 2043230. Author Affiliation: Division of Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: At the end of the eighteenth and beginning of the nineteenth centuries, yellow fever epidemics occurred frequently in America and Europe, in the vicinity of the Mediterranean, Atlantic, and Caribbean coasts. There is only brief information available on the 1804-5 epidemic in San Juan, but it shows that mortality in the city was inordinate. Nevertheless, the minutes of the meetings of the Municipal Assembly in this period make no mention of the epidemic, and allude to it only in veiled fashion. In spite of the accumulation of individual tragedies (for example, it is likely that the two daughters of governor Ramón de Castro were among the victims), the documents show little evidence of community reaction to the epidemic, which apparently ceased in mid-1805
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AU  - Nussenblatt, R B
TI  - The natural history of uveitis
JO  - International Ophthalmology
PY  - 1990/01/01/
VL  - 14
IS  - 5-6
SP  - 303
EP  - 308
SN  - 01655701
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2249907. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2249907. Author Affiliation: National Eye Institute, National Institutes of Health, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: Inflammatory diseases of the eye were known to the ancients, but only recently have the underlying mechanisms to this problem become better defined. During the middle portion of this century, most cases of uveitis thought to be caused by infectious agents, such as those responsible for syphilis and tuberculosis. Since then, it has become clear that endogenous mechanisms of immunomodulation play an important role in these disorders, which along with environmental and genetic factors make up an important triad. Animals studies have indicated the pivotal role of the T-cell in many of these disorders. The development of T-cell lines has helped to further delineate cell to cell interactions that occur during an ocular inflammatory event. The presence in the eye of uveitogenic antigens raises the strong possibility of autoimmune driven processes as well, similar to what is seen in the animal models. The better understanding of ocular inflammatory mechanisms has led to improved therapeutic strategies, including Sandimmune, and more recently Cyclosporine G, a related compound that may be less nephrotoxic. Newer therapeutic strategies will focus on even more novel modes of immunomodulation, probably without the use of medications
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TY  - JOUR
AU  - Mauger AB
TI  - Naturally Occurring Proline Analogues
JO  - Journal of Natural Products
PY  - 1996/01/01/
VL  - 59
IS  - 12
SP  - 1205
EP  - 1211
SN  - 01633864
N1  - Note: E-mail: mauger@dtpax2.ncifcrf.gov. Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-021977. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-021977. Author Affiliation: Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program National Cancer Institute, Bethesda, Maryland 20892  (Anthony B. Mauger) 1; 
AB  - ALNAP Abstract: Introduction: Two earlier reviews (in 1966 and 1977) were published on the subject of proline analogs, 1,2 including bothe natural and synthetic compounds. The present review is restricted to naturally occurring compounds based upon t he pyrrolidine-2-carboxylic acid structure, both as the free amino acids and embedded in larger structures, usually peptides (however, analogues incorporated by 'directed biosynthesis' are not covered) Unlike the earlier reviews, 1,2 the present compilation does not include the compounds with other ring sizes such as azetidine-2-carboxylic acid and pipecolic acid. N-Substituted derivatives of proline itself are not included, but those of proline analogs are. The compounds reviewed are discussed in terms of source, structure, and biological activity ( where relevant), but not synsins inhibit the polymerization of tubulin and depolymerize preformed microtubules. 10
KW  - Senait
KW  - Senait
KW  - acid
KW  - activity
KW  - amino acid
KW  - Amino acids
KW  - Analogs
KW  - analogues
KW  - azetidine-2-carboxylic acid
KW  - biological
KW  - Biological activities
KW  - biological activity
KW  - cancer
KW  - chemistry
KW  - compound
KW  - compounds
KW  - Derivatives
KW  - drug
KW  - free amino acid
KW  - naturally occurring
KW  - Occurring
KW  - Peptide
KW  - Peptides
KW  - pipecolic acid
KW  - review
KW  - Reviews
KW  - Ring
KW  - structure
KW  - structures
KW  - synthesis
KW  - synthetic
KW  - synthetic compound
KW  - therapeutic
KW  - therapeutics
KW  - Tubulin
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AU  - Harris, M I
TI  - Noninsulin-dependent diabetes mellitus in black and white Americans
JO  - Diabetes - Metabolism Reviews
PY  - 1990/01/01/
VL  - 6
IS  - 2
SP  - 71
EP  - 90
SN  - 07424221
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2198151. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2198151. Author Affiliation: National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: This report presents an overview of the prevalence, characteristics, morbidity, mortality, and risk factors for noninsulin-dependent diabetes (NIDDM) in Blacks and Whites in the United States. Data are drawn primarily from national surveys, but the report also includes the few clinical studies that have differentiated the two races. NIDDM constitutes 90-95% of all diabetes in the United States and is more prevalent in Black Americans than in Whites. Diabetes prevalence increases with age for both races and reaches 26% among Blacks aged 65-74 years compared with 18% among Whites. Rates of diabetes among persons aged 20-74 years are 30% higher in White women, 70% higher in Black men, and 100% higher in Black women, compared with White men. Approximately half of diabetes is undiagnosed in both races. White and Black diabetics are similar with regard to age, duration of diabetes, and diabetes therapies, although Blacks of both sexes are more obese than their White counterparts. Rates of vision loss, amputations, and renal disease are 1.5-4 times higher in Blacks than in Whites, although prevalence of hypertension is about equal in the two races. Blacks and Whites see the same physician specialists for their diabetes, but Whites have approximately 40% more visits to office-based physicians each year. Diabetes-specific mortality has declined significantly in the past decade and may now be lower in Black than in White diabetics. Risk factors for diabetes, including age, sex, obesity, and family history of diabetes, all operate within both race groups and probably interact with each other. The effect of gender and family history on rates of diabetes is similar in Blacks and Whites. Blacks have higher rates of diabetes at each obesity level, indicating that obesity alone cannot explain the differential in prevalence between the races. Impaired glucose tolerance (IGT), a strong risk factor for development of diabetes, increases with age in all race/sex groups except for Black women older than 54 years in whom rates of IGT, decline, possibly because of conversion of IGT to diabetes
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TY  - GEN
AU  - Murthy, P
AU  - Jayakumar, P N
AU  - Sampat, S
TI  - Of insects and eggs: a case report
JO  - Journal of Neurology, Neurosurgery and Psychiatry
PY  - 1997/01/01/
VL  - 63
IS  - 4
SP  - 522
EP  - 523
PB  - BMJ Publishing Group LTD: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom
SN  - 00223050
N1  - Database Contributor: HEALTHLIT. Database Contributor ID: 789492. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Other. Publication Type: Short Communication. Accession Number: 789492. Author Affiliation: 1997-1997 Year - Bangalore, 560 029, India, National Institute of Mental Health, Department of Psychiatry 1; 
AB  - HEALTHLIT Abstract: <p> A middle aged woman presented with delusions of infestation and multimodal hallucinations due to an underlying glioma of the corpus callosum. After surgery, the phenomena in question changed and finally disappeared. A recurrence of the tumour caused dementia.</p>
KW  - Medical Science
KW  - Health / Public health
KW  - Medical Science
KW  - Health / Public health
KW  - delusions
KW  - hallucinations
KW  - glioma
KW  - dementia
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ER  - 

AU  - Krause, R M
TI  - The origin of plagues: old and new
JO  - Science
PY  - 1992/01/01/
VL  - 257
IS  - 5073
SP  - 1073
EP  - 1078
SN  - 00368075
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; Molecular Sequence: GENBANK/M95929. Database Contributor: MEDLINE. Database Contributor ID: 1509258. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1509258. Author Affiliation: Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Viruses and bacteria emerge in new and old forms to cause disease epidemics. Some microorganisms recur when changing life-styles (including increased international travel) offer new opportunities; others arise from new genetic variations. These various epidemics connect the future with the past, offering lessons for guarding the health of generations to come--lessons learned from diseases such as tuberculosis, toxic shock syndrome, Lyme disease, streptococcal infection, influenza, and acquired immunodeficiency syndrome (AIDS). The public must be vigilant to the possibility of new epidemics, learn more about the biology and epidemiology of microbes, and strengthen systems of surveillance and detection
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AU  - Malik, I A
TI  - Out-patient management of febrile neutropenia in indigent paediatric patients
JO  - Academy of Medicine, Singapore. Annals
PY  - 1997/01/01/
VL  - 26
IS  - 6
SP  - 742
EP  - 746
SN  - 03044602
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; A4P49JAZ9H. Database Contributor: MEDLINE. Database Contributor ID: 9522971. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9522971. Author Affiliation: Department of Medical Oncology, National Cancer Institute, Clifton, Karachi, Pakistan 1; 
AB  - MEDLINE Abstract: Affordability of costly in-patient medical care and accessibility to the few cancer centres are serious problems faced by cancer patients in developing countries. Febrile neutropenia in particular is a major problem because delay in institution of antibiotic therapy can be rapidly fatal. We conducted a prospective non-randomised trial to evaluate the efficacy of administration of oral ofloxacin by caregivers to paediatric cancer patients with fever and neutropenia. Patients receiving chemotherapy who resided for away and were unable to reach the oncology ward within 12 hours of onset of fever or were unable to afford the expensive in-patient care were eligible for inclusion in the study. Requirements for enrollment included an absolute neutrophil count of < or = 0.5 x 10(9)/L, a temperature of > or = 38 degrees C, and ability to take oral medications. Caregivers were instructed to immediately administer oral ofloxacin on recognition of fever and to maintain constant contact with the oncology staff. Eighty-five of the 91 episodes were evaluable. These were most patients with solid tumours or non-Hodgkin's lymphoma (79%). Duration of neutropenia and fever was short and majority had pyrexia of undetermined origin (84%). Seventy-seven (91%) of the febrile episodes responded to ofloxacin with resolution of fever and neutropenia and hospitalisation was never required. Eight (9%) patients required hospitalisation. Most of them had prolonged neutropenia. They all responded to parenteral antibiotic therapy. No toxicity was observed and the cost of therapy was negligible. Out-patient therapy with oral ofloxacin may be an alternative to hospitalisation for those paediatric patients who are unable to afford or do not have access to in-patient care
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AU  - Rodgers, G P
TI  - Overview of pathophysiology and rationale for treatment of sickle cell anemia
JO  - Seminars in Hematology
PY  - 1997/01/01/
VL  - 34
IS  - 3 Suppl 3
SP  - 2
EP  - 7
SN  - 00371963
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 9004-22-2; 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 9317195. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9317195. Author Affiliation: Hematology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1822, USA 1; 
AB  - MEDLINE Abstract: Sickle cell anemia occurs in individuals who are homozygous for a single nucleotide substitution in codon 6 of the beta-globin gene. This single mutation leads to the formation of abnormal hemoglobin, HbS (alpha2betas[s]2), which is much less soluble when deoxygenated than hemoglobin A (HbA) (alpha2beta2). This insolubility causes aggregates of HbS to form inside sickle erythrocytes as they traverse the circulation. With full deoxygenation, polymer becomes so extensive that the cells become sickled in shape. Yet, even with high oxygen saturation values, quantities of HbS polymer may be sufficient to alter the rheologic properties of sickle erythrocytes in the absence of morphologic changes, and cells can occlude end arterioles, leading to chronic hemolysis and microinfarction of diverse tissues. Ultimately, this process leads to vaso-occlusive crises and irreversible tissue damage. Nonetheless, the spectrum of disease severity even among patients with grossly equivalent hematologic indices suggests that many other factors-including genetic, cellular, physiologic, and psychosocial-play a substantial role in determining the course of this disorder. Of the genetic factors, the level of fetal hemoglobin in particular has been established to favorably modify the clinical manifestations of patients with sickle cell disease and related conditions. Recent advances in the understanding of the molecular and cellular pathophysiology of sickle cell disease, coupled with new insights into the developmental regulation of human globin gene expression, have provided the scientific impetus and clinical rationale to attempt to augment the postnatal production of fetal hemoglobin. Furthermore, contemporary understanding of the quantitative relationship between the extent of HbS polymerization within the red cells and the degree of red blood cell and/or organ pathology has now enabled investigators to predict to what extent this intracellular pathogenic process must be inhibited to achieve clinically significant amelioration of disease manifestation. These areas will be covered in this overview. This is a US government work. There are no restrictions on its use
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AU  - Kapikian, A Z
TI  - Overview of viral gastroenteritis
JO  - Archives of Virology. Supplementum
PY  - 1996/01/01/
VL  - 12
SP  - 7
EP  - 19
SN  - 09391983
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9015097. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9015097. Author Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 1; 
AB  - MEDLINE Abstract: Diarrheal illnesses in humans have been recognized since antiquity. Such illnesses continue to take a great toll of lives, with a disproportionately high mortality in infants and young children in developing countries. Bacteriologic and parasitologic advances made during the past century led to the discovery of the etiology of some of the diarrheal illnesses, but the etiology of the major portion remained unknown. It was assumed that viruses caused most of these illnesses because: (i) bacteria were recovered from only a small proportion of episodes, and (ii) bacteria-free filtrates were found to induce gastroenteritis in adult volunteer studies. However, an etiologic agent could not be recovered despite the "golden age" of virology in the 1950's and 1960's when tissue culture technology enabled the discovery of numerous cultivatable enteric viruses, none of which emerged as an important etiologic agent of gastroenteritis. The discoveries of the Norwalk virus in 1972, and of rotaviruses in 1973, both without the benefit of in vitro tissue culture systems, ushered in a new era in the study of the etiology of viral gastroenteritis. The Norwalk virus was found to be an important cause of non-bacterial epidemic gastroenteritis in adults and older children, and rotaviruses were shown to be the single most important etiologic agents of severe diarrheal illnesses of infants and young children in both developed and developing countries. With the major advances in the study of rotaviruses, there is a high degree of optimism that in the not-too-distant future, a rotavirus vaccine will be available. In addition, the recent molecular biologic advances in the study of the Norwalk and Norwalk-like viruses, now firmly established as caliviviruses, represent a major new horizon in the study of these viruses
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AU  - Georgiev, V S
TI  - Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis
JO  - Current Pharmaceutical Design
PY  - 1999/01/01/
VL  - 5
IS  - 7
SP  - 545
EP  - 554
SN  - 13816128
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 81G6I5V05I; F4216019LN. Database Contributor: MEDLINE. Database Contributor ID: 10438896. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10438896. Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 1; 
AB  - MEDLINE Abstract: Necator americanus is a nematode hookworm of the family Ancylostomatidae, subfamily Necatorinae. This nematode parasite, which is distinguished by two chitinous cutting plates in the buccal cavity and fused male copulatory spicules, is the causative agent of necatoriasis, a hookworm disease prevalent in the Americas as well as in the tropical regions of Africa, southern Asia, and Polynesia. The adult parasites attached to the villi of the small intestines will suck blood causing abdominal discomfort, diarrhea and cramps, anorexia, wight loss, and in advanced disease, hypochromic microcytic anemia. Hookworm infections in man, especially in children, are one of the leading causes of iron-deficiency anemia resulting directly from intestinal capillary blood loss following the feeding activities of fourth-stage (L4) larva and adult worms. Another clinical manifestation often associated with hookworm infections is cutaneous larva migrans (CLM). It is a well recognized, usually self-limiting condition caused by the infectious larvae of nematodes. CLM is characterized by skin eruption and represents a clinical description rather than a definitive diagnosis. Of the hookworm parasites, the dog and cat worm Ancylostoma braziliense is the most common causing CLM, although many other species have been implicated. The major subject of this review article will be discussion of the evolution of therapies and treatment of human necatoriasis and the development of experimental infections with N. americanus. Difference in the clinical efficacies of mebendazole and albendazole will be discussed along with drug resistance of N. americanus
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AU  - Magrath, I
TI  - The pathogenesis of Burkitt's lymphoma
JO  - Advances in Cancer Research
PY  - 1990/01/01/
VL  - 55
SP  - 133
EP  - 270
SN  - 0065230X
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2166998. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2166998. Author Affiliation: Lymphoma Biology Section, National Cancer Institute, Bethesda, Maryland 20892 1; 
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DB  - awn
ER  - 

AU  - Israel, M A
TI  - Pediatric oncology: model tumors of unparalleled import
JO  - National Cancer Institute. Journal
PY  - 1989/01/01/
VL  - 81
IS  - 6
SP  - 404
EP  - 408
SN  - 00278874
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 2645407. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2645407. Author Affiliation: Molecular Genetics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Molecular studies of tumors arising during childhood have provided insights important for our understanding of the genetic and cellular events that now seem likely to mediate the development of many different malignancies. Of particular interest have been recent studies using recombinant DNA technology to study the pressure genetic alterations now thought to be central features of oncogenesis. Oncogenes and recessive cancer genes, first recognized to be of clinical importance during the study of Burkitt's lymphoma and retinoblastoma, are now thought to play a role in the development of most, if not all, tumors. Studies to identify more effective approaches to cancer prevention, detection, staging, and treatment are now seeking to build upon an understanding of those genetic alterations. It can be expected that pediatric oncology will once again play a pivotal role as these studies mature into clinical trials
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ER  - 

AU  - Mulatu, M S
TI  - Perceptions of Mental and Physical Illnesses in North-western Ethiopia: Causes, Treatments, and Attitudes
JO  - Journal of Health Psychology
PY  - 1999/01/01/
VL  - 4
IS  - 4
SP  - 531
EP  - 549
SN  - 13591053
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 22021645. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 22021645. Author Affiliation: National Institute of Mental Health, Bethesda, Maryland, USA 1; 
AB  - MEDLINE Abstract: Four hundred and fifty adults (mean age 34 years; 55 percent males) from northwestern Ethiopia were interviewed to explore their causal beliefs about, perceived importance of various treatments for, and attitudes towards, six mental and three physical illnesses. Principal components analysis identified four meaningful illness causal belief dimensions: Psychosocial Stressors, Supernatural Retribution, Biomedical Defects, and Socio-Environmental Deprivation. Psychosocial Stressors and Supernatural Retribution were rated more important causes of mental than physical illnesses. Prayer and home/family care were suggested more strongly for treating mental than physical illnesses. Systematic associations were found between causal beliefs, treatment beliefs, and attitudes towards patients. Respondents' educational level was negatively related with traditional beliefs and positively related with favorable attitudes towards patients. It is concluded that causal beliefs, perceived importance of treatments, and attitude towards patients among northwestern Ethiopians are meaningfully interrelated. Implications for health services and research are discussed
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AU  - Rodgers, G P
TI  - Pharmacological therapy
JO  - Bailliere's Clinical Haematology
PY  - 1998/01/01/
VL  - 11
IS  - 1
SP  - 239
EP  - 255
SN  - 09503536
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 10872480. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10872480. Author Affiliation: Molecular and Clinical Hematology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1822, USA 1; 
AB  - MEDLINE Abstract: Collectively sickle cell disease and beta-thalassaemia are the most commonly inherited single-gene defects world-wide and were the first group of diseases for which DNA-based detection strategies were utilized. Although genotypically distinct, these two groups of diseases exhibit several common clinical features: moderate-to-severe haemolytic anaemia, acute and progressive tissue damage, disease- or treatment-related organ failure and premature death. Within the last two decades, a striking improvement in life expectancy in the two patient populations has been observed, by dint of primary and secondary prevention strategies. However, apart from bone marrow transplantation, a generally applicable, specific and non-toxic form of treatment remains unavailable for these disorders. Nonetheless, a greater appreciation of the developmental control of human globin gene expression coupled with observations of the effects of certain classes of agents to 'reverse' erythroid cellular phenotype in in vitro and animal models have led to pharmacological trials to obtain meaningful increases in haemoglobin F production in patients affected by these two severe beta-globin disorders. Contemporary understanding of the quantitative relationship between the abnormal molecules in the red cells (aggregates of sickle haemoglobin) in the sickle cell syndromes and aggregated alpha-globin polypeptides in the beta-thalassemia syndromes, and the extent of the red cell and/or organ involvement, has now enabled investigators to predict how much inhibition of these intracellular pathogenic processes might be necessary to achieve partial or total abrogation of disease manifestations. The results of the Multicenter Study of Hydroxyurea and other controlled trials now bear out these predictions
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AU  - Shahabuddin, M
TI  - Plasmodium ookinete development in the mosquito midgut: a case of reciprocal manipulation
JO  - Parasitology
PY  - 1998/01/01/
VL  - 116 Su
SP  - S83
EP  - S93
SN  - 00311820
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9695113. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9695113. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA 1; 
AB  - MEDLINE Abstract: The ookinete is one of the most important stages of Plasmodium development in the mosquito. It is morphologically and biochemically distinct from the earlier sexual stages--gametocytes and zygote, and from the later stages--oocyst and sporozoites. Development to ookinete allows the parasite to escape from the tightly packed blood bolus, to cross the sturdy peritrophic matrix (PM), to be protected from the digestive environment of the midgut lumen, and to invade the gut epithelium. The success of each of these activities may depend on the degree of the biochemical and physical barriers in the mosquito (such as density of blood bolus, thickness of peritrophic matrix, proteolytic activities in the gut lumen etc.) and the ability of the ookinete to overcome these barriers. Ookinete motility, secretion of chitinase, resistance to the digestive enzymes, and recognition/invasion of the midgut epithelium all may play crucial roles in the transformation to oocyst. The overall sporogonic development of Plasmodium, therefore, depends on the results of the two-way manipulations between the parasite and the vector mosquito. Study of ookinete development and of the cellular and biochemical complexities of the mosquito gut may therefore lead to the design of novel strategies to block the transmission of malaria. This article reviews the intricate interactions between the parasite and the mosquito midgut in the context of development and transmission of Plasmodium parasites
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AU  - Brining, S K
TI  - Predicting the in vitro toxicity of synthetic beta-amyloid [1-40]
JO  - Neurobiology of Aging
PY  - 1997/01/01/
VL  - 18
IS  - 6
SP  - 581
EP  - 589
SN  - 01974580
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 3U05FHG59S; E-mail: skb@helix.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9461056. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9461056. Author Affiliation: The National Institutes of Health, The National Institute on Aging, Bethesda, MD 20892-1582, USA 1; 
AB  - MEDLINE Abstract: The in vitro toxicity of synthetic beta-amyloid (betaA4) is variable and unpredictable, limiting its use as a research tool. This study describes a method using Congo red (CR) to predict the in vitro toxicity of betaA4 solutions. Histopathologically, CR is used to stain the neuritic, betaA4-containing plaques, one of the hallmarks of Alzheimer's disease. In this study, synthetic betaA4 solutions were incubated with CR at a molar ratio of 1.0:2.5. The solutions were centrifuged and the absorbance of the supernatants were measured. Predictions of nontoxicity correlated with absorbance readings near zero. Toxicity was evaluated relative to control cells (vehicle only), using a hemocytometer to count PC-12 cells that excluded trypan blue. The positive predictive value of the test was 78% and the negative predictive value was 100%. To use this test, the toxic concentration(s) of betaA4 must first be established empirically. Then, the CR test can be used to evaluate the potential toxicity of betaA4 solutions at similar concentrations. Thus, this test can be used under a variety of laboratory circumstances
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AU  - Puribhat, S
TI  - Present status of cancer treatment in several Asian countries
JO  - Gan To Kagaku Ryoho
PY  - 1992/01/01/
VL  - 19
IS  - 8 Suppl
SP  - 1153
EP  - 1159
SN  - 03850684
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1514828. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1514828. Author Affiliation: National Cancer Institute, Phayathai Bangkok, Thailand 1; 
AB  - MEDLINE Abstract: Most of Asian Countries are still developing. Hence there are constraints in cancer treatment. There are those countries with fully equipped and fully distributed like western world such as Japan, Korea and Singapore. Other with some comprehensive cancer centers but confine to only big cities with poor coverage of the population resulting in a lot of late cases of cancer patients seen. Such countries are Bangladesh, China, India, Indonesia, Malaysia, Sri-Lanka, Thailand and etc. Still a lot of countries have no facilities to cope with cancer patients such as Brunei, Kampuchea, Laos, Nepal, Vietnam and etc. International collaboration and supports are needed
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AU  - Contacos, P G
TI  - Primate malarias: man and monkeys
JO  - Journal of Wildlife Diseases
PY  - 1970/01/01/
VL  - 6
IS  - 4
SP  - 323
EP  - 328
SN  - 00903558
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 16512134. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 16512134. Author Affiliation: Section on Primate Malaria Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health, Chamblee, Georgia 30341, USA 1; 
AB  - MEDLINE Abstract: The question whether malarias of animals could be considered true zoonoses was examined. The research in this connection for the past decade or so was reviewed. That simian malarias are true zoonoses has been adequately demonstrated. In addition, there is great potential for human malarias being true anthroponoses. The author considers, therefore, that the significance of non-human reservoirs of human malaria in the control or eradication of malaria should be reconsidered
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AU  - Goedert, J J
TI  - Prognostic markers for AIDS
JO  - Annals of Epidemiology
PY  - 1990/01/01/
VL  - 1
IS  - 2
SP  - 129
EP  - 139
SN  - 10472797
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1669494. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1669494. Author Affiliation: Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Human immunodeficiency virus (HIV) infection causes a number of clinical syndromes and many laboratory abnormalities, often heralding the development of the life-threatening opportunistic infections or malignancies that are known as the acquired immunodeficiency syndrome (AIDS). Drawing heavily on the results of prospective cohort studies, particularly those that my colleagues at the National Cancer Institute and I have conducted, this paper reviews the relationship of AIDS to clinical signs and symptoms, immunologic measures, and viral assays. The risk of AIDS in the next 3 years is at least 25 to 50% for HIV-infected subjects who have oral candidiasis, unexplained fever, unexplained weight loss, a CD4+ lymphocyte count below 200 cells/microliter, or combinations of these. Elevated serum levels of beta 2 microglobulin and neopterin also appear to be strong predictive markers of AIDS, but further work is needed in diverse HIV-infected populations, such as intravenous drug users and persons in pattern II countries, such as Haiti and central Africa. Elevated levels of interferon or HIV-p24 antigen in the serum are insensitive but highly specific AIDS markers that may have predictive value independent of CD4 lymphocyte levels. Several potentially valuable immunologic (immunoglobulin levels, tumor necrosis factor, soluble interleukin 2) and virologic (HIV viremia) assays remain to be thoroughly evaluated or technically simplified. Data from prospective cohort studies have provided clinical and laboratory markers of AIDS risk that have proved essential for therapeutic trials and other clinical decisions. As effective treatments for HIV infection and its complications begin to emerge, these marker data will also prove invaluable for mathematic modeling of the scope, course, and public health response to the epidemic
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AU  - Blaese, R M
TI  - Progress toward gene therapy
JO  - Clinical Immunology and Immunopathology
PY  - 1991/01/01/
VL  - 61
IS  - 2 Pt 2
SP  - S47
EP  - S55
SN  - 00901229
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; EC Number: 3.5.4.4. Database Contributor: MEDLINE. Database Contributor ID: 1934613. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1934613. Author Affiliation: Cellular Immunology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: The prospect of treating human disease at its most fundamental (i.e., genetic) level has been the dream of clinicians for decades. There are over 4000 distinct genetic diseases, many of which are debilitating or fatal and most of which are incurable by standard medical approaches. Initial research was directed toward gene replacement treatment of genetic diseases involving the bone marrow, such as sickle cell anemia. Efficient methods for gene transfer were developed, but as this research progressed it became apparent that the biology of the bone marrow stem cell and the regulation of hemoglobin synthesis were not understood well enough to realistically permit an attempt at gene therapy for these diseases. These difficulties spurred research on alternative approaches which has unexpectedly led to the development of techniques to use gene therapy for the treatment of both rare genetic disorders as well as more common "nongenetic" diseases such as cancer. Our research has focused on one of the most promising cellular alternatives to the bone marrow stem cell, the T lymphocyte. This paper summarizes the historical background and evolution of thinking which led to the initial clinical applications of gene transfer and gene therapy in man
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AU  - Nutman, T B
TI  - Protective immunity in lymphatic filariasis
JO  - Experimental Parasitology
PY  - 1989/01/01/
VL  - 68
IS  - 2
SP  - 248
EP  - 252
SN  - 00144894
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2647512. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2647512. Author Affiliation: Clinical Parasitology Section, National Institutes of Health, Bethesda, Maryland 20892 1; 
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AU  - Sriram, T G
TI  - Psychotherapy in developing countries: a public health perspective
JO  - Indian Journal of Psychiatry
PY  - 1990/01/01/
VL  - 32
IS  - 2
SP  - 138
EP  - 144
SN  - 00195545
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 21927442. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 21927442. Author Affiliation: Lecturer in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029 1; 
AB  - MEDLINE Abstract: Psychotherapy is being increasingly recognised as an important treatment modality for various mental health problems. However, minimal efforts have been made to examine the utility of psychotherapy from the public health perspective, especially for developing countries. This paper outlines the present situation in developing countries with respect to the magnitude of mental health and related problems requiring psychotherapeutic help, the existing health and mental health facilities, the current training in psychiatry and psychotherapy in different training programmes, and the current state of mental health knowledge and skills of primary care personnel. A number of strategies for public health action are delineated to enhance the availability of this form of treatment to the large number of people requiring psychotherapeutic help. The needs for systematic research in this area are highlighted
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AU  - Lodmell, D L
TI  - Rabies DNA vaccines for protection and therapeutic treatment
JO  - Expert opinion on investigational drugs
PY  - 1999/01/01/
VL  - 8
IS  - 2
SP  - 115
EP  - 122
SN  - 17447658
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: Dlodmell@atlas.niaid.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 15992067. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15992067. Author Affiliation: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA 1; 
AB  - MEDLINE Abstract: Rabies is a successful zoonotic disease that has persisted over time, achieving worldwide distribution in a variety of species. Annually, in developing countries with limited access to high-quality antirabies biologics, approximately 50,000 individuals and millions of animals die of rabies. Many of these countries continue to use vaccines produced in sheep, goat or suckling mouse brain, with ultraviolet light or phenol inactivation of the virus. Although there are several efficacious rabies vaccines derived from cultured cells, such as the human diploid cell vaccine, they are costly to produce and prohibitively expensive for developing countries. DNA vaccines offer a new and powerful approach for the generation of needed vaccines. They are stable, inexpensive to produce, easy to construct and induce a full spectrum of long-lasting humoral and cellular immune responses. This review concerns the present state of rabies DNA vaccines, and addresses the technology that may enhance their therapeutic efficacy
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AU  - Harris, M I
TI  - Racial and ethnic differences in health insurance coverage for adults with diabetes
JO  - Diabetes Care
PY  - 1999/01/01/
VL  - 22
IS  - 10
SP  - 1679
EP  - 1682
SN  - 01495992
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: harrism@ep.niddk.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 10526734. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10526734. Author Affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 1; 
AB  - MEDLINE Abstract: OBJECTIVE: To evaluate the extent and types of health insurance coverage in a representative sample of adults with diabetes in the U.S. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans aged > or = 20 years. Information on medical history and treatment of diabetes was obtained to determine subjects who had been diagnosed with diabetes by a physician before the survey (n = 1,503) and subjects without diagnosed diabetes (n = 17,319). Information on health insurance coverage was obtained via a structured questionnaire for 96% of participants. RESULTS: A total of 93% of all adults with diabetes had some form of health insurance. Of these subjects, 73% had private insurance, 48% had Medicare coverage, 15% had Medicaid coverage, and 5% had Champus/Veterans Affairs coverage. Approximately 52% of adults with diabetes had multiple types of health insurance, and 54% had health care coverage through one or more government-sponsored programs. A greater proportion of non-Hispanic whites (91%) and non-Hispanic blacks (89%) than Mexican-Americans (66%) had health insurance among subjects aged 20-64 years. For those aged > or = 65 years, coverage was virtually 100% for all racial and ethnic groups. Non-Hispanic whites had the highest rate of coverage through private insurance (81%), with non-Hispanic blacks having an intermediate rate (56%) and Mexican-Americans having the lowest rate (45%). Rates of coverage were similar for adults with and without diabetes in each racial and ethnic group for any type of insurance and for private insurance. CONCLUSIONS: There are marked racial and ethnic differences in health insurance coverage for adults with diabetes, although these differences are similar to those for adults without diabetes. Whether these racial and ethnic disparities influence access to care, quality of care, or health outcomes for people with diabetes remains to be determined
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AU  - Rodgers, G P
TI  - Recent approaches to the treatment of sickle cell anemia
JO  - J A M A: The Journal of the American Medical Association
PY  - 1991/01/01/
VL  - 265
IS  - 16
SP  - 2097
EP  - 2101
SN  - 00987484
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 1707463. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1707463. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1; 
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AU  - O'Brien, S J
TI  - A role for molecular genetics in biological conservation
JO  - National Academy of Sciences of the United States of America. Proceedings
PY  - 1994/01/01/
VL  - 91
IS  - 13
SP  - 5748
EP  - 5755
SN  - 00278424
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 7912434. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7912434. Author Affiliation: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201 1; 
AB  - MEDLINE Abstract: The recognition of recent accelerated depletion of species as a consequence of human industrial development has spawned a wide interest in identifying threats to endangered species. In addition to ecological and demographic perils, it has become clear that small populations that narrowly survive demographic contraction may undergo close inbreeding, genetic drift, and loss of overall genomic variation due to allelic loss or reduction to homozygosity. I review here the consequences of such genetic depletion revealed by applying molecular population genetic analysis to four endangered mammals: African cheetah, lion, Florida panther, and humpback whale. The accumulated genetic results, combined with physiological, ecological, and ethological data, provide a multifaceted perspective of the process of species diminution. An emerging role of population genetics, phylogenetics, and phylogeography as indicators of a population's natural history and its future prognosis provides valuable data of use in the development of conservation management plans for endangered species
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AU  - James, S L
TI  - Role of nitric oxide in parasitic infections
JO  - Microbiological Reviews
PY  - 1995/01/01/
VL  - 59
IS  - 4
SP  - 533
EP  - 547
SN  - 01460749
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 31C4KY9ESH. Database Contributor: MEDLINE. Database Contributor ID: 8531884. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8531884. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA 1; 
AB  - MEDLINE Abstract: Nitric oxide is produced by a number of different cell types in response to cytokine stimulation and thus has been found to play a role in immunologically mediated protection against a growing list of protozoan and helminth parasites in vitro and in animal models. The biochemical basis of its effects on the parasite targets appears to involve primarily inactivation of enzymes crucial to energy metabolism and growth, although it has other biologic activities as well. NO is produced not only by macrophages and macrophage-like cells commonly associated with the effector arm of cell-mediated immune reactivity but also by cells commonly considered to lie outside the immunologic network, such as hepatocytes and endothelial cells, which are intimately involved in the life cycle of a number of parasites. NO production is stimulated by gamma interferon in combination with tumor necrosis factor alpha or other secondary activation signals and is regulated by a number of cytokines (especially interleukin-4, interleukin-10, and transforming growth factor beta) and other mediators, as well as through its own inherent inhibitory activity. The potential for design of prevention and/or intervention approaches against parasitic infection (e.g., vaccination or combination chemo- and immunotherapy strategies) on the basis of induction of cell-mediated immunity and NO production appears to be great, but the possible pathogenic consequences of overproduction of NO must be taken into account. Moreover, more research on the role and regulation of NO in human parasitic infection is needed before its possible clinical relevance can be determined
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AU  - Murthy, R S
TI  - Rural psychiatry in developing countries
JO  - Psychiatric Services
PY  - 1998/01/01/
VL  - 49
IS  - 7
SP  - 967
EP  - 969
SN  - 10752730
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: rsm@nimhans.ren.nic.in. Database Contributor: MEDLINE. Database Contributor ID: 9661237. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9661237. Author Affiliation: National Institute of Mental Health and Neuro Sciences, India 1; 
AB  - MEDLINE Abstract: During the last two decades several initiatives have been taken to improve psychiatric services in low-income rural areas in developing countries. They have included the formulation of national mental health programs and establishment of pilot programs for integration of mental health care with primary health care in India, Iran, and other countries in Asia, Africa, and South America. The psychiatrist has multiple roles to play in meeting the many challenges of providing mental health care in rural areas in developing countries
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AU  - Cheever, A W
TI  - Schistosomiasis. Infection versus disease and hypersensitivity versus immunity
JO  - American Journal of Pathology
PY  - 1993/01/01/
VL  - 142
IS  - 3
SP  - 699
EP  - 702
SN  - 00029440
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 8456933. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8456933. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1; 
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ER  - 

AU  - Mahmoud, H K
TI  - Schistosomiasis as a predisposing factor to veno-occlusive disease of the liver following allogeneic bone marrow transplantation
JO  - Bone Marrow Transplantation
PY  - 1996/01/01/
VL  - 17
IS  - 3
SP  - 401
EP  - 403
SN  - 02683369
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8704694. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8704694. Author Affiliation: BMT Unit, National Cancer Institute, Cairo University, Egypt 1; 
AB  - MEDLINE Abstract: Among 89 allogeneic bone marrow transplant recipients, veno-occlusive disease of the liver (VOD) was diagnosed in 10 patients (11.2%). All cases (n = 5) with schistosomal hepatic periportal fibrosis detected by pretransplant ultrasonography, developed severe fatal VOD in spite of normal initial liver functions and absence of portal hypertension. The incidence of VOD among patients without previous schistosomal contact was 5.95% (5/84). The relative risk to develop VOD was calculated to be 16.8-fold higher in patients with previous schistosomiasis. Schistosomal hepatic periportal fibrosis may thus be added to the known risk factors predisposing to the development of VOD in allogeneic transplant recipients
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AU  - Caughey, B
TI  - Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues
JO  - Royal Society of London. Philosophical Transactions. Biological Sciences
PY  - 1994/01/01/
VL  - 343
IS  - 1306
SP  - 399
EP  - 404
SN  - 09628436
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 3U05FHG59S; 64082-61-7; EC Number: 3.4.-. Database Contributor: MEDLINE. Database Contributor ID: 7913757. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7913757. Author Affiliation: Laboratory of Persistent Viral Diseases, NIH Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, Hamilton, Montana 59840 1; 
AB  - MEDLINE Abstract: An abnormally protease-resistant and apparently neuropathogenic form of PrP accumulates in the brains of hosts with scrapie and related transmissible spongiform encephalopathies. Studies with scrapie-infected neuroblastoma cells have highlighted dramatic differences in the metabolism of the normal (protease-sensitive) and scrapie-associated (protease-resistant) isoforms of PrP. Furthermore, this model has been useful in identifying inhibitors of protease-resistant PrP accumulation and scrapie agent replication which are valuable as potential therapeutic agents and as probes of the mechanism of protease-resistant PrP formation. These inhibitors include the amyloid stain Congo red and certain sulphated glycans which are glycosaminoglycans themselves or glycosaminoglycan analogues. The relative potencies of various sulphated glycans correlate with their previously determined anti-scrapie activities in vivo, suggesting that the prophylactic effects of sulphated polyanions is due to inhibition of protease-resistant PrP accumulation. These and other observations suggest that an interaction of PrP with endogenous sulphated glycosaminoglycans or proteoglycans is important in protease-resistant PrP accumulation, and raise the possibility that therapies for transmissible spongiform encephalopathies and other amyloidoses could be based on blocking (pre)amyloid-glycosaminoglycan interactions
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AU  - Caughey, B
TI  - Scrapie associated PrP accumulation and its prevention: insights from cell culture
JO  - British Medical Bulletin
PY  - 1993/01/01/
VL  - 49
IS  - 4
SP  - 860
EP  - 872
SN  - 00071420
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 8137133. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8137133. Author Affiliation: Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, Hamilton, Montana 59840 1; 
AB  - MEDLINE Abstract: Transmissible spongiform encephalopathies (TSEs), Alzheimer's disease and other amyloidoses result in the accumulation of abnormally stable, potentially amyloidogenic proteins that appear to play central roles in disease pathogenesis. Scrapie-infected tissue culture cells have become well-developed models for studying how the TSE-specific protein, protease-resistant PrP, is made from its apparently normal precursor. The conversion of PrP to the protease-resistant state occurs on the plasma membrane or along an endocytic pathway to the lysosomes. The protease-resistant PrP has a much longer half-life than normal PrP and its accumulation in lysosomes may feature in TSE pathogenesis. Congo red and certain sulfated glycans potently inhibit protease-resistant PrP formation or stabilization in cell culture. These and other observations suggest that an interaction of PrP with glycosaminoglycans is critical in protease-resistant PrP accumulation and raises the possibility that therapeutic strategies for TSEs and other amyloidoses could be based on blocking (pre)amyloid-glycosaminoglycan interactions
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ER  - 

AU  - Schechter, A N
TI  - Sickle cell disease expenditures and outcomes
JO  - Public Health Reports
PY  - 1997/01/01/
VL  - 112
IS  - 1
SP  - 38
EP  - 39
SN  - 00333549
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: aschecht@helix.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9018286. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9018286. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1822, USA 1; 
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AU  - Gaston, M H
TI  - Sickle cell disease: an overview
JO  - Seminars in Roentgenology
PY  - 1987/01/01/
VL  - 22
IS  - 3
SP  - 150
EP  - 159
SN  - 0037198X
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3310245. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3310245. Author Affiliation: Sickle Cell Disease Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892 1; 
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AU  - Rodgers, G P
TI  - Sickle-cell trait and physical training. Evidence for improved fitness
JO  - Archives of Internal Medicine
PY  - 1988/01/01/
VL  - 148
IS  - 5
SP  - 1019
EP  - 1020
SN  - 00039926
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3365071. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3365071. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes and Diseases of the Kidney, National Institutes of Health, Bethesda, Md 20892 1; 
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AU  - Minton, A P
TI  - Solubility relationships in binary mixtures of hemoglobin variants Application to the "gelationrd of sickle-cell hemoglobin
JO  - Biophysical Chemistry
PY  - 1974/01/01/
VL  - 1
IS  - 5
SP  - 387
EP  - 395
SN  - 03014622
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 23260428. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 23260428. Author Affiliation: Laboratory of Biophysical Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA 1; 
AB  - MEDLINE Abstract: A thermodynamic treatment of solubility in binary mixtures of hemoglobin variants is presented. It is shown that the reported dependence of the minimum gelling concentration in five binary mixtures of the variants S, C(Harlem') Korle-Bu and A may be satisfactorily accounted for using the derived solubility relations together with simple models relating structure to interaction energies in the condensed phase.;
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AU  - Rodgers, G P
TI  - Spectrum of fetal hemoglobin responses in sickle cell patients treated with hydroxyurea: the National Institutes of Health experience
JO  - Seminars in Oncology
PY  - 1992/01/01/
VL  - 19
IS  - 3 Suppl 9
SP  - 67
EP  - 73
SN  - 00937754
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 1379375. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1379375. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: Hydroxyurea is one of several cytostatic agents that increase fetal hemoglobin (HbF) production in some patients with sickle-cell disease, although their mechanisms of action remain to be defined. We have studied the effects of hydroxyurea in several hospitalized patients with sickle-cell disease treated for 3 months, who were then maintained on outpatient therapy. Among hydroxyurea-treated patients, we found that about 75% respond with at least a twofold increase in the percentages of F reticulocytes and HbF. Among the responders, HbF levels increased twofold to 10-fold, with three patients achieving levels of 10% to 15%. Statistical analysis of the three cellular variables that determine HbF levels in patients with sickle-cell disease--namely, increased F-cell production, F-cell survival, and HbF/F cells--disclosed that HbF production, as measured by an increase in F reticulocytes, accounted for about 70% of the HbF elevation, with smaller contributions coming from augmentation of HbF/F cells and preferential survival of F cells. Four responders were re-treated with their optimal weekly hydroxyurea dose, given either in daily fractions or over 4 consecutive days, after a 1- to 3-month washout period. Greater HbF responses were attained with the optimal hydroxyurea dose than with the dose-regimen escalation, and usually occurred after a lag period. Furthermore, increases in HbF and F-cell levels were more rapid in patients receiving therapy on 4 out of 7 days rather than on a daily schedule. Our calculations show that the increases in HbF/F and F cells and the decrease in the fraction of dense cells during limited hydroxyurea administration should cause a significant improvement in intracellular sickle hemoglobin polymerization tendency. Controlled prospective trials are necessary to establish whether these effects lead to clinical benefit. Alternate schedules of hydroxyurea administration, or its use in conjunction with other means to elevate HbF or reduce mean cell hemoglobin concentration, may achieve greater inhibition of polymerization and thus be more likely to result in unequivocal amelioration of disease manifestations
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AU  - Miller, L H
TI  - Strategies for malaria control: realities, magic, and science
JO  - New York Academy of Sciences. Annals
PY  - 1989/01/01/
VL  - 569
SP  - 118
EP  - 126
SN  - 00778923
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2698081. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2698081. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; 
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AU  - Thom, T J
TI  - Stroke mortality trends. An international perspective
JO  - Annals of Epidemiology
PY  - 1993/01/01/
VL  - 3
IS  - 5
SP  - 509
EP  - 518
SN  - 10472797
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7513238. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7513238. Author Affiliation: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1; 
AB  - MEDLINE Abstract: This article presents death rates for cerebrovascular disease (stroke) by sex for ages 35 to 74 years in 1990 for 52 countries, and trends in rates from 1950 to 1990 for 30 countries. Rates are high in Asia and eastern Europe. In most industrialized countries, large declines occurred, particularly over the last 2 decades. The United States and Canada have low rates. Portugal, Trinidad, Paraguay, Mauritius, China, Korea, and most eastern European countries have the highest rates. Japan, with very high stroke mortality in the 1950s, experienced the largest absolute and percent decline and now ranks above western Europe and North America but below most other countries. In most industrialized countries, except in eastern Europe, stroke death rates declined more than 50% since 1970, somewhat more in women than in men. There is more uniformity in trends since 1970 than in earlier years. In several countries, either a downward slope accelerated in the 1970s, or a rising trend was reversed
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AU  - Berzofsky, J A
TI  - Structural features of T-cell recognition: applications to vaccine design
JO  - Royal Society of London. Philosophical Transactions. Biological Sciences
PY  - 1989/01/01/
VL  - 323
IS  - 1217
SP  - 535
EP  - 544
SN  - 09628436
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2474171. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2474171. Author Affiliation: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: T lymphocytes, in contrast to antibodies, appear to recognize primarily a limited number of antigenic sites on any given antigenic protein. We find that a single site can so dominate the T-cell repertoire that the presence or absence of a response to one immunodominant site can make the difference between a high responder and a low responder, even though low responders respond to other sites almost as well as high responders. Besides interaction with major histocompatibility complex (MHC) molecules, the mode by which the antigen is processed into fragments for T-cell recognition also determines which sites are seen. The products of natural processing of the protein appear to be larger than the synthetic peptides and contain structures which hinder binding to certain MHC molecules or to the T-cell receptor. A third factor in immunodominance is the intrinsic structure of the antigenic site. We have shown that amphipathic helices have a higher than random chance of being immunodominant, and have developed a computer program to locate such structures in protein amino acid sequences. We prospectively predicted sites in the malaria circumsporozoite protein and found that the four most widely recognized sites in an endemic area of West Africa were all predicted. Similarly, we identified two helper T-cell sites from the HIV (AIDS virus) envelope, and have now shown that immunization with these elicits enhanced antibody responses to the whole envelope when injected into monkeys. These sites are also recognized by human T cells from volunteers who had been immunized with a recombinant vaccinia virus expressing the HIV envelope. Also, because cytotoxic T lymphocytes (CTLS) may play a critical role in defence against AIDS, we have used a recombinant vaccinia virus and transfectants expressing the HIV envelope gene to induce specific CTLS against the HIV envelope. Using synthetic peptides, we were able to identify the first CTL recognition site in the AIDS virus. These results may contribute to the rational design of vaccines
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AU  - Ugel, A R
TI  - Studies on isolated aggregating oligoribonucleoproteins of the epidermis with histochemical and morphological characteristics of keratohyalin
JO  - Journal of Cell Biology
PY  - 1971/01/01/
VL  - 49
IS  - 2
SP  - 405
EP  - 422
SN  - 00219525
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 19866768. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 19866768. Author Affiliation: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 1; 
AB  - MEDLINE Abstract: Histochemical and ultrastructural studies demonstrate that keratohyalin can be mobilized from fresh specimens of cattle hoof epidermis by 1.0 M potassium phosphate buffer (pH 7.0). Macroaggregates with histochemical characteristics identical to those of in situ keratohyalin granules (staining by Harris' hematoxylin, Congo red, diazotized sulfanilic acid, sodium alizarin sulfonate, toluidine blue, methyl green-pyronin, and acridine orange) and with similar morphological characteristics at the ultrastructural level are formed upon dialyzing the extracted keratohyalin against distilled water. Staining by basic dyes (toluidine blue, methyl green-pyronin, and acridine orange) is abolished by treating either in situ keratohyalin granules or isolated macroaggregates with ribonuclease. Electrophoresis of isolated macroaggregates on polyacrylamide gels in the presence of sodium decylsulfate results in the fractionation of a 13 member oligomeric series of ribonucleoproteins and two non-homologous species of ribonucleoproteins. The oligomeric series can be purified by isolating "stacked" oligomers on low concentration (3%) polyacrylamide gels. Fractionated oligomers on polyacrylamide gels and aggregates formed from purified ribonucleoproteins demonstrate histochemical characteristics identical to those of in situ keratohyalin granules. Aggregates formed from denatured ribonucleoproteins are highly disordered and are markedly different from in situ keratohyalin granules or nondenatured isolated macroaggregates at the ultrastructural level, possibly due to irreversible denaturation of the oligomers by sodium decylsulfate
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AU  - Brawley, O W
TI  - The study of untreated syphilis in the negro male
JO  - International Journal of Radiation: Oncology - Biology - Physics
PY  - 1998/01/01/
VL  - 40
IS  - 1
SP  - 5
EP  - 8
SN  - 03603016
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 9422551. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9422551. Author Affiliation: Office of Special Populations Research, National Cancer Institute, Bethesda, MD 20892, USA 1; 
AB  - MEDLINE Abstract: PURPOSE: The participation of minorities in clinical studies is the subject of much discussion and has even become the subject of Federal law. The project known as the Tuskegee Syphilis Study and officially titled "The Tuskegee Study of Untreated Syphilis in the Negro Male," is one of the great debacles of American medicine and a national shame. Despite the fact that its existence is well known, many do not know the historical facts of the study nor the context of the study. My purpose here is to recount the facts of the study and its historical context. METHODS: The history recounted here is taken from documents gathered during a U.S. Senate investigation of the study, original papers located in National Library of Medicine, and books about the trial. RESULTS: The trial began in 1931 as a survey of the natural history of untreated tertiary syphilis in Black men. This study enrolled 399 men with syphilis and 201 uninfected men to serve as controls. All were at least 25 years old at enrollment. The men were told they were in a study, but never educated about the implications. Later, men were not informed that there was a treatment for effective treatment for their disease--a treatment that was being withheld from them. This trial continued till 1972. CONCLUSION: Many of the issues that led to the study and caused it to continue for 40 years still exist. The lessons of the Public Health Study of Untreated Syphilis in the Untreated Negro include the dangers of paternalism, arrogance, blind loyalty, and misuse of science. "Those who do not appreciate history are condemned to repeat it" (Alfred North Whitehead)
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AU  - Rosner, J L
TI  - Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid
JO  - Antimicrobial Agents and Chemotherapy
PY  - 1993/01/01/
VL  - 37
IS  - 10
SP  - 2251
EP  - 2253
SN  - 00664804
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; V83O1VOZ8L; EC Number: 1.-; 1.11.1.-; 1.11.1.15; 1.11.1.6; Genome Sequence: ahpC; ahpF; katG; oxyR. Database Contributor: MEDLINE. Database Contributor ID: 8257155. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8257155. Author Affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Escherichia coli and Salmonella typhimurium are normally resistant to > 500 micrograms of the antituberculosis drug isonicotinic acid hydrazide (isoniazid; INH) per ml. Susceptibility to INH (< 50 micrograms/ml) has now been found for mutants that are deficient in OxyR, the oxidative stress response regulator. Two OxyR-regulated enzymes, alkyl hydroperoxide reductase and hydroperoxidase I, were identified as playing important roles in INH resistance. OxyR regulon mutants should be useful for identifying other determinants of INH resistance in both E. coli and Mycobacterium tuberculosis and for finding new INH-like drugs
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AU  - Good, M F
TI  - T cells, T sites, and malaria immunity: further optimism for vaccine development
JO  - Journal of Immunology
PY  - 1988/01/01/
VL  - 140
IS  - 6
SP  - 1715
EP  - 1716
SN  - 00221767
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3279122. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3279122. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1; 
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AU  - Kaslow, D C
TI  - Transmission-blocking immunity against malaria and other vector-borne diseases
JO  - Current Opinion in Immunology
PY  - 1993/01/01/
VL  - 5
IS  - 4
SP  - 557
EP  - 565
SN  - 09527915
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 8216932. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8216932. Author Affiliation: Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; 
AB  - MEDLINE Abstract: Antibodies to sexual stage malaria parasites block transmission of Plasmodium by female mosquitoes. With the recent isolation of genes encoding several of the target antigens of transmission-blocking antibodies, the development of a subunit transmission-blocking vaccine against malaria is now a realistic goal
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AU  - St Georgiev, V
TI  - Treatment and developmental therapeutics of Mycobacterium tuberculosis infections
JO  - International Journal of Antimicrobial Agents
PY  - 1994/01/01/
VL  - 4
IS  - 3
SP  - 157
EP  - 173
SN  - 09248579
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 18611607. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 18611607. Author Affiliation: National Institute of Allergy and Infectious Diseases, NIH, Solar Building, Room 4C-04, Bethesda, MD 20892, USA 1; 
AB  - MEDLINE Abstract: Tuberculosis still remains a serious health problem in many regions of the world, especially in developing nations. With the spread of AIDS and the increase in the number of immunocompromised patients, the problem of tuberculosis has been greatly exacerbated because of the susceptibility of such patients to mycobacteria. Currently, chemotherapy using multiple drug regimens with isoniazid, rifampin, streptomycin, pyrazinamide, and ethambutol is the recommended treatment for tuberculosis. The presence of drug resistance is still a major concern and new generations of more effective antimycobacterial agents (antibiotics, fluoroquinolone derivatives) are the subject of active investigation. The search for novel strategies to cure tuberculosis led to studies exploring the role of cytokines in host defenses and the application of adoptive immunotherapy. New and improved methodology for in vitro and in vivo screening of antimycobacterial activity has also been reported
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AU  - LeMasters, C Z
TI  - Treatment of pulmonary tuberculosis
JO  - Lippincott's Primary Care Practice
PY  - 1999/01/01/
VL  - 3
IS  - 1
SP  - 55
EP  - 58
SN  - 10885471
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 10214202. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10214202. Author Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 1; 
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ER  - 

AU  - Ginsberg, A M
TI  - The tuberculosis epidemic. Scientific challenges and opportunities
JO  - Public Health Reports
PY  - 1998/01/01/
VL  - 113
IS  - 2
SP  - 128
EP  - 136
SN  - 00333549
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; E-mail: ag73i@nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9719813. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9719813. Author Affiliation: Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA 1; 
AB  - MEDLINE Abstract: One in every three people on Earth is believed to be infected with Mycobacterium tuberculosis, leading to seven to eight million cases of active tuberculosis (TB) per year and approximately three million deaths annually. this epidemic, like those of most infectious diseases, creates scientific challenges and opportunities as it raises the demand for public health solutions. The currently available weapons for fighting TB are inadequate. The ultimate goal of biomedical TB research is to lessen the public health burden of this disease by developing improved diagnostic, therapeutic, and intervention strategies. Achieving this goal requires a base of knowledge about the biology of M. tuberculosis and related mycobacteria, their interactions with human and animal hosts, and the nature of an effective host-protective immune response. TB researchers are applying this accumulating base of knowledge to developing rapid, easy-to-use diagnostic assays appropriate for low-as well as high-income countries, improving the current complicated therapeutic regimen, identifying potential new drugs to combat multidrug-resistant TB, and creating more effective vaccines
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ER  - 

AU  - Novakovic, B
TI  - U.S. childhood cancer survival, 1973-1987
JO  - Medical and Pediatric Oncology
PY  - 1994/01/01/
VL  - 23
IS  - 6
SP  - 480
EP  - 486
SN  - 00981532
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7935174. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7935174. Author Affiliation: Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 1; 
AB  - MEDLINE Abstract: The surveillance, epidemiology, and end-results (SEER) data on 5-year relative survival rates (1973-1987) for the most common pediatric tumors (ages 0-14) were analyzed. The SEER data are population based, so the observed progress in survival from childhood cancer represents the real impact that development in cancer treatment had on the population followed by the registry. The greatest increase in survival rate from 1973 until 1987 has been achieved in hematopoietic tumors such as acute lymphocytic leukemia (ALL), in which survival increased from 47.6% (1973-1977) to 60.8% (1983-1987), and Burkitt's lymphoma in which survival increased from 27.6% (1973-1977) to 68.7% (1983-1987). Solid tumors showed a less steep, but steady increase in survival rates. Flattening in the survival rates since 1978-1982 has been observed for acute leukemia, astrocytoma, medulloblastoma, and osteosarcoma. Females have better survival rates for most pediatric tumors, except Hodgkin's disease. Analysis of race of childhood leukemia confirmed that black children have worse survival than white. When solid tumors were analyzed by stage at presentation, there was no indication that diagnosis in earlier stages of disease accounted for the improved survival. Observed flattening in the survival rates since 1978-1982 of leukemia and some solid tumors warrants further follow-up
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ER  - 

AU  - Gad-el-Mawla, N
TI  - Use of ifosfamide in the management of breast cancer
JO  - Annals of Oncology
PY  - 1992/01/01/
VL  - 3 Su
IS  - 3
SP  - 21
EP  - 23
SN  - 09237534
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: UM20QQM95Y. Database Contributor: MEDLINE. Database Contributor ID: 1390313. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1390313. Author Affiliation: National Cancer Institute, Fom-El-Khalig, Cairo, Egypt 1; 
AB  - MEDLINE Abstract: Ifosfamide, a cytostatic drug highly active in vivo, has slight superiority over cyclophosphamide. It proved effective in experimental tumor systems including the C3H mammary carcinoma. Clinical studies of ifosfamide as monotherapy in breast cancer, begun in 1974 by Ahmann et al., reported a 20% objective response. Subsequent trials were conducted from 1974 through 1977 using ifosfamide as monotherapy, and ifosfamide was also combined with other chemotherapeutic agents. In 1975, Hartwich and coworkers used the combination ifosfamide/vincristine with a 25% overall response. With the introduction of the uroprotector mesna, more studies were instituted. In 1984, using the IMF combination (ifosfamide/methotrexate/5-fluorouracil), we reported a 25% overall response. Other groups also reported good results for ifosfamide-containing combinations, with overall responses ranging from 25% to 79%. Recently, Sanchiz and Milla used high-dose ifosfamide to treat metastatic breast cancer, with a 40% overall response. In conclusion, ifosfamide's efficacy in breast cancer has been confirmed and the drug is highly recommended in combination chemotherapy as a first-line treatment
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ER  - 

AU  - de The, G
TI  - Viruses and human cancers: challenges for preventive strategies
JO  - Environmental Health Perspectives
PY  - 1995/01/01/
VL  - 103 Su
IS  - 8
SP  - 269
EP  - 273
SN  - 00916765
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; E-mail: dethe@pasteur.fr. Database Contributor: MEDLINE. Database Contributor ID: 8741797. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8741797. Author Affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland and Institut Pasteur, Unit of Epidemiology of Oncogenic Viruses, Paris, France 1; 
AB  - MEDLINE Abstract: Virus-associated human cancers provide unique opportunities for preventive strategies. The role of human papilloma viruses (HPV 16 and 18), hepatitis B virus (HBV), Epstein-Barr herpes virus (EBV), and retroviruses (human immunodeficiency virus [HIV] and human T-cell leukemia/lymphoma virus [HTLV]) in the development of common carcinomas and lymphomas represents a major cancer threat, particularly among individuals residing in developing countries, which account for 80% of the world's population. Even though these viruses are not the sole etiological agents of these cancers (as would be the case for infectious diseases), different approaches can be implemented to significantly decrease the incidence of virus-associated malignancies. The first approach is vaccination, which is available for HBV and possibly soon for EBV. The long delay between primary viral infection and development of associated tumors as well as the cost involved with administering vaccinations detracts from the feasibility of such an approach within developing countries. The second approach is to increase efforts to detect pre-cancerous lesions or early tumors using immunovirological means. This would allow early diagnosis and better treatment. The third strategy is linked to the existence of disease susceptibility genes, and suggests that counseling be provided for individuals carrying these genes to encourage them to modify their lifestyles and other conditions associated with increased cancer risks (predictive oncology). Specific recommendations include: a) increase international studies that explore the causes of the large variations in prevalence of common cancers throughout the world; b) conduct interdisciplinary studies involving laboratory investigation and social sciences, which may suggest hypotheses that may then be tested experimentally; and c) promote more preventive and health enhancement strategies in addition to curative and replacement therapies
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Ottesen, E A
TI  - The Wellcome Trust Lecture. Infection and disease in lymphatic filariasis: an immunological perspective
JO  - Parasitology
PY  - 1992/01/01/
VL  - 104 Su
EP  - 58
SN  - 00311820
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1589302. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1589302. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20892 1; 
AB  - MEDLINE Abstract: The basic tenet of the immunological perspective of filarial disease is that differential immune responsiveness among individuals exposed to infection results in the different clinical manifestations that develop. The mechanisms involved in this differential responsiveness appear to reflect different T-cell cytokine response patterns. Asymptomatic patients with the clinically silent presentation of 'asymptomatic microfilaraemia', who have been previously described as being 'immunosuppressed' with respect to their generating pro-inflammatory (Th1-type) immune responses to parasite antigen, are now recognized to be fully responsive to parasite antigen but to produce cytokines and mediators that have primarily anti-inflammatory (Th2-like) effects. Studies with immunodeficient mice have indicated the existence of two alternative pathways to the development of lymphatic pathology: one dependent on the induction of inflammatory reactions by the host immune response, the other entirely independent of the immune system and reflecting the direct actions of the parasite or its products on the lymphatics. As histopathology of affected human lymphatics is consistent with this hypothesis, it may be that the lymphatic pathology seen normally in the amicrofilaraemic, highly immunoresponsive infected patients derives from inflammation induced by immune responses to parasite antigen, whereas the lymphatic pathology sometimes seen coexisting with the 'immunosuppressed' state of asymptomatic microfilaraemia actually reflects lymphatic damage that is not immunologically mediated. Though little information exists about the 'natural history' of lymphatic filariasis, there is no evidence for an inevitable progression from one clinical form to another.(ABSTRACT TRUNCATED AT 250 WORDS)
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DB  - awn
ER  - 

AU  - Schwan, T G
TI  - Xenopsylla bantorum is an east African subspecies of X. cheopis [Siphonaptera: Pulicidae]
JO  - Journal of Medical Entomology
PY  - 1992/01/01/
VL  - 29
IS  - 6
SP  - 927
EP  - 933
SN  - 00222585
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1460630. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1460630. Author Affiliation: Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840 1; 
AB  - MEDLINE Abstract: The geographic distribution, host association, and male genital morphology of Xenopsylla bantorum Jordan were examined and compared with the Nilotic and Oriental "strains" of Xenopsylla cheopis (Rothschild). The more acute shape of the ninth sternite separates X. bantorum from all types of X. cheopis; however, the length of the first process of the male's clasper and the number of setae on this process are significantly different among all three groups; the Nilotic strain of X. cheopis is intermediate to the others. Specimens collected from both wild and commensal rodents in Nakuru, Kenya, were all X. bantorum, suggesting that X. cheopis present early in the century that resulted from introductions on Rattus rattus had been absorbed by the native X. bantorum population. These factors and a review of opinions by others concerning the status of X. bantorum demonstrate that this flea is not specifically distinct from X. cheopis. The trinomial X. cheopis bantorum is erected. Furthermore, the Nilotic and Oriental "strains" of X. cheopis are distinguishable morphologically solely by the length of the male's first process
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DB  - awn
ER  - 

AU  - Srivastava, M
TI  - Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane
JO  - Journal of Biological Chemistry
PY  - 1995/01/01/
VL  - 270
IS  - 39
SP  - 22714
EP  - 22720
SN  - 00219258
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 11130-51-1; Molecular Sequence: GENBANK/U29460; GENBANK/U29461; GENBANK/U29462; GENBANK/U29463; GENBANK/U29464; GENBANK/U29469. Database Contributor: MEDLINE. Database Contributor ID: 7559396. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7559396. Author Affiliation: Laboratory of Cell Biology and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA 1; 
AB  - MEDLINE Abstract: Cytochrome b561 is an electron transfer protein unique to neuroendocrine secretory vesicles. The Southern blot hybridization shows that it is a single copy gene highly conserved throughout phylogeny. The transcription unit spans approximately 11 kilobases, and heterologous transcription sites are located 404 bases 5' to the translation initiation codon. The sequence of the 5'-flanking region is GC-rich and lacks a typical TATA box at the usual position. However, it has a CAAT sequence at -132 and potential recognition sequences for several transcription factors including SP1, GR-PR-MMTV, AP4, gERE, JCV repeat, AP2, and NF-kappa B. Each of the five transmembrane segments are encoded by five consecutive exons. This corroborates the five-transmembrane model proposed for human, mouse, and Xenopus rather than six proposed for bovine. The cytochrome was found to be highly expressed in colon cancer cell lines, T cell lymphomas, and K-562 cell lines. However, in B-cell lymphomas such as Burkitt's and Daudi, the cytochrome b561 expression was completely shut down. The results in this report are the first to demonstrate the structural organization and regulatory sequences of the cytochrome b561 gene encoding an integral membrane protein of neuroendocrine storage vesicles of neurotransmitters and peptide hormones. Unexpected results on cytochrome b561 expression in cells of lymphocytic origin and its complex regulation in tumor cells provide new insights into cytochrome b561 gene regulation
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DP  - EBSCOhost
DB  - awn
ER  - 

AU  - Desai, S A
TI  - A nutrient-permeable channel on the intraerythrocytic malaria parasite
JO  - Novartis Foundation Symposium
PY  - 1999/01/01/
VL  - 226
SP  - 89
SN  - 15282511
N1  - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; Contract Number: Z01 AI000882-07/AI/NIAID NIH HHS. Database Contributor: MEDLINE. Database Contributor ID: 10645540. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10645540. Author Affiliation: National Institutes of Health/National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, MD 20814, USA 1; 
AB  - MEDLINE Abstract: The intraerythrocytic malaria parasite Plasmodium falciparum faces at least three membranous barriers to acquisition of nutrients from serum: the human erythrocyte membrane, the parasitophorous vacuole membrane (PVM) and the parasite plasma membrane. The PVM is a specialized parasite-derived membrane that separates the parasite from erythrocyte cytosol. I used the patch clamp method to identify and characterize the main transport pathway on the PVM. Gigaohm seals, formed on mature freed trophozoites, revealed a 140 pS channel permeable to both cations and anions on the PVM. This channel is present at high density, is open more than 95% of the time at the PVM resting potential, and is capable of transporting amino acids and monosaccharides across the PVM. This nutrient-permeable channel was then reconstituted into artificial lipid bilayers, where it exhibited similar slope conductances, gating, voltage dependence and permeability to soluble nutrients. In bilayers, the channel was found to have non-saturating kinetics and an effective pore diameter of 23 A. These experiments, together with the patch clamp findings, suggest a high capacity molecular sieve that allows the parasite to acquire soluble nutrients from erythrocyte cytosol
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DP  - EBSCOhost
DB  - awn
ER  - 

TY  - JOUR
T1  - The National Filaria Control Program (NFCP) of India: investigative challenges.
AU  - BEYE, H. K.
AU  - WRIGHT, W. H.
JO  - Bulletin of the National Society of India for Malaria and other Mosquito-Borne Diseases
JF  - Bulletin of the National Society of India for Malaria and other Mosquito-Borne Diseases
Y1  - 1959///
VL  - 7
IS  - 2
SP  - 45
EP  - 52
AD  - BEYE, H. K.: U.S. Department of Health, Education & Welfare, Public Health Service, National Institutes of Health, Bethesda 14, Maryland, U.S.A.
N1  - Accession Number: 19610801377. Publication Type: Journal Article. Language: not specified. 
N2  - Beye & Wright outline a variety of research projects that might be undertaken by the National Filaria Control Programme of India in its efforts to control, and ultimately eradicate, infections due to Wuchereria bancrofti and W. malayi. J. W. Smith.
KW  - control programmes
KW  - infections
KW  - India
KW  - Brugia malayi
KW  - Onchocercidae
KW  - Wuchereria
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - South Asia
KW  - Asia
KW  - Developing Countries
KW  - Commonwealth of Nations
KW  - control programs
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - The prophylactic activity of 1-maleinyl-4-(3'-chloro-4'-methyl-phenyl)-piperazine(Hoechst S 688) in experimental schistosome infections.
AU  - LUTTERMOSER, G. W.
AU  - BRUCE, J. I.
AU  - MCMULLEN, D. B.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1959///
VL  - 45
IS  - 4, Sect. 2
SP  - 54
EP  - 55
SN  - 0022-3395
AD  - LUTTERMOSER, G. W.: National Institutes of Health, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610802749. Publication Type: Journal Article. Language: not specified. 
N2  - For abstract of full account of this work see No. 2750 below.].
KW  - infections
KW  - prophylaxis
KW  - Pesticides and Drugs (General) (HH400)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - [English title not available] / Neuere Untersuchungen aus dem Gebiet der Parasitenphytiologie.
AU  - VON BRAND, T.
JO  - Zeitschrift fur Tropenmedizin und Parasitologie
JF  - Zeitschrift fur Tropenmedizin und Parasitologie
Y1  - 1959///
VL  - 10
IS  - 2
SP  - 123
EP  - 134
AD  - VON BRAND, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda 14, Maryland, U.S.A.
N1  - Accession Number: 19600802213. Publication Type: Journal Article. Language: not specified. 
N2  - Von Brand reviews recent work on the physiology of parasites. He also discusses the factors that have influenced the development of work in this field and the way the problems are approached. The value of work in which an over-all view of metabolism is sought is discussed in relation to studies in which one particular enzyme or group of enzymes is examined in detail. W. P. Rogers.
KW  - parasites
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Development in vitro of some parasitic nematodes of vertebrates.
AU  - WEINSTEIN, P. P.
AU  - JONES, M. F.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1959///
VL  - 77
IS  - 2
SP  - 137
EP  - 162
SN  - 0077-8923
AD  - WEINSTEIN, P. P.: Laboratory of Tropical Diseases, National Institute of Allergy and Infectious Diseases, Public Health Service, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610800260. Publication Type: Journal Article. Language: not specified. 
N2  - Weinstein & Jones describe some recent investigations on the growth and maintenance of nematode larvae in vitro. A basal medium of serum-chick embryo homogenate was used. In relatively high concentrations of these materials filariform larvae of Nippostrongylus muris were capable of reaching the fifth stage. Human serum was compared directly with rat serum and found to be superior. However, considerable variations in the yield of fifth-stage worms occurred with different samples of the same basal medium. Supplements such as a vitamin mixture, Eagles' medium and liver concentrate increased the fifth-stage worm yield. The worms did not mate in culture but infertile eggs were deposited by the females. In chemically defined media alone, or with supplements added, survival but no growth occurred. Under strict axenic conditions, development from egg to mature adult was obtained without the use of antibiotics. Worms which were removed from the intestine of the rat did not mate during in vitro culture. Third-stage larvae of Necator americanus showed some development when cultured by similar techniques. J. E. D. Keeling.
KW  - antibiotics
KW  - blood serum
KW  - culture media
KW  - embryos
KW  - in vitro
KW  - in vitro culture
KW  - larvae
KW  - liver
KW  - nematode larvae
KW  - supplements
KW  - survival
KW  - techniques
KW  - Ancylostomatidae
KW  - man
KW  - Necator
KW  - Necator americanus
KW  - Nematoda
KW  - Nippostrongylus
KW  - rats
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Ancylostomatidae
KW  - Necator
KW  - Heligmonellidae
KW  - Muridae
KW  - rodents
KW  - small mammals
KW  - chemically defined media
KW  - Secernentea
KW  - Strongylida
KW  - third stage larvae
KW  - Pesticides and Drugs (General) (HH400)
KW  - Techniques and Methodology (ZZ900)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - A comparison of the development of some rat and mouse helminths in germfree and conventional guinea pigs.
AU  - NEWTON, W. L.
AU  - WEINSTEIN, P. P.
AU  - JONES, M. F.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1959///
VL  - 78
IS  - 1
SP  - 290
EP  - 306
SN  - 0077-8923
AD  - NEWTON, W. L.: Laboratory of Tropical Diseases, National Institute of Allergy and Infectious Diseases, Public Health Service, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610800093. Publication Type: Journal Article. Language: not specified. 
N2  - guineapigs which had been delivered and maintained germ-free were compared with conventional guineapigs as hosts for a number of helminths normally parasitic in rats and mice. In conventional animals Nippostrongylus muris failed to develop but fourth-stage larvae and adults were recovered from two of six germ-free guineapigs which received similar infections. Germ-free animals proved more satisfactory hosts for Nematospiroides dubius than did conventional animals. It was demonstrated that the method of delivery and type of diet were not the underlying reason for this difference. Both species produced fertile eggs in germ-free animals. Hymenolepis nana developed successfully in both types of host. J. E. D. Keeling.
KW  - helminths
KW  - infections
KW  - methodology
KW  - small mammals
KW  - techniques
KW  - guineapigs
KW  - Heligmosomoides
KW  - Heligmosomoides polygyrus
KW  - Hymenolepididae
KW  - Hymenolepis
KW  - mice
KW  - Nippostrongylus
KW  - rats
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Heligmosomidae
KW  - Nematoda
KW  - invertebrates
KW  - Heligmosomoides
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - Hymenolepididae
KW  - Muridae
KW  - small mammals
KW  - Heligmonellidae
KW  - Cyclophyllidea
KW  - guinea pigs
KW  - methods
KW  - parasitic worms
KW  - Secernentea
KW  - Strongylida
KW  - Vampirolepis
KW  - Vampirolepis nana
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Studies on chemotherapy of experimental schistosomiasis. V. Enhancement of the schistosomacidal activity of tartar emetic and stibophen by glycerin.
AU  - LUTTERMOSER, G. W.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1959///
VL  - 45
IS  - 3
SP  - 301
EP  - 309
SN  - 0022-3395
AD  - LUTTERMOSER, G. W.: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610802748. Publication Type: Journal Article. Language: not specified.  Registry Number: 15489-16-4, 28300-74-5.
N2  - Luttermoser has attempted to increase the schistosomicidal activity of tartar emetic and stibophen by the addition of one of several possible organic adjuvants; only glycerin, of 32 compounds tested, was successful. 50 mg. or 75 mg. of tartar emetic per kg. body-weight given orally twice a day for five days or 160 mg. of stibophen per kg. given intraperitoneally six times in five days reduced Schistosoma mansoni infection in mice by about 50%. The same regimen of tartar emetic given in a 50% aqueous solution of glycerin reduced the infection by about 74%; the same regimen of stibophen given in a 25% aqueous solution of glycerin reduced the infection by about 79%. Glycerin given alone either orally or parenterally did not kill any schistosomes. Multiple injections of 25% glycerin solutions of tartar emetic or stibophen into the tail vein of mice usually resulted in haematoma and leakage of the drug into the tissues. The acute toxicity of both tartar emetic and stibophen for uninfected mice was similar irrespective of whether the drugs were given in aqueous or in glycerin solution or as single or multiple doses; similar results were obtained with uninfected dogs. Luttermoser discusses the possible ways in which glycerin might enhance the activity of these drugs; the stability of tartar emetic in vitro was increased by the addition of glycerin, which suggests that in vivo this adjuvant could maintain the level of the drug in the blood for a longer period of time so enhancing its activity. J. W. Smith.
KW  - adjuvants
KW  - drug therapy
KW  - emetics
KW  - in vitro
KW  - infections
KW  - regimens
KW  - schistosomiasis
KW  - snail-borne diseases
KW  - stibophen
KW  - toxicity
KW  - toxicology
KW  - trematode infections
KW  - dogs
KW  - mice
KW  - Schistosoma
KW  - Schistosoma mansoni
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - small mammals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Schistosoma
KW  - antimonials
KW  - antimonyl potassium tartrate
KW  - bilharzia
KW  - bilharziasis
KW  - chemotherapy
KW  - fluke infections
KW  - in vivo
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Hepato-splenic schistosomiasis in mice.
AU  - DEWITT, W. B.
AU  - WARREN, K. S.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1959///
VL  - 8
IS  - 4
SP  - 440
EP  - 446
SN  - 0002-9637
AD  - DEWITT, W. B.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19600800950. Publication Type: Journal Article. Language: not specified. 
N2  - Mice infected with approximately 125 cercariae of Schistosoma mansoni harboured an average burden of 24 worms per animal. In the liver maximum egg density was reached at eight weeks after infection (1, 765 per gm.). At ten weeks the mice showed symptoms which are normally associated with the syndrome designated hepato-splenic schistosomiasis, namely, liver enlargement with granulomatous lesions or scar tissue around deposited eggs, splenomegaly, oesophageal varices and ascites. Some mice also developed a severe anaemia. Histológical examination revealed little damage to liver parenchyma. Liver function test results could be attributed to abnormal conditions produced by portal hypertension. These observations suggested that the pathogenesis of the syndrome was directly related to mechanical obstruction of the portal blood flow produced by tissue reaction associated with schistosome eggs. J. E. D. Keeling.
KW  - anaemia
KW  - ascites
KW  - cercariae
KW  - granuloma
KW  - hepatomegaly
KW  - hypertension
KW  - infections
KW  - liver
KW  - liver cells
KW  - liver function
KW  - oesophagus
KW  - parenchyma
KW  - pathogenesis
KW  - portal hypertension
KW  - schistosomiasis
KW  - snail-borne diseases
KW  - spleen
KW  - splenomegaly
KW  - symptoms
KW  - trematode infections
KW  - mice
KW  - Schistosoma
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - small mammals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Schistosoma
KW  - anemia
KW  - bilharzia
KW  - bilharziasis
KW  - esophagus
KW  - fluke infections
KW  - hepatocytes
KW  - high blood pressure
KW  - liver enlargement
KW  - schistosomosis
KW  - Strigeida
KW  - syndromes
KW  - Non-communicable Human Diseases and Injuries (VV600)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Recent advances in carbohydrate biochemistry of helminths.
AU  - Brand, T. von
JO  - Helminthological Abstracts
JF  - Helminthological Abstracts
Y1  - 1960///
VL  - 29
IS  - 2
SP  - 97
EP  - 111
CY  - Wallingford; UK
PB  - CABI Publishing
AD  - Brand, T. von: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, USA.
N1  - Accession Number: 20063028328.  Publication Type: Journal Article.  Language: English.  Number of References: many ref. Subject Subsets: Helminthology; Veterinary Science
KW  - biochemistry
KW  - biosynthesis
KW  - carbohydrate metabolism
KW  - carbohydrates
KW  - helminths
KW  - polysaccharides
KW  - reviews
KW  - complex carbohydrates
KW  - parasitic worms
KW  - saccharides
KW  - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW  - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW  - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000)
KW  - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A three-year epidemiologic study of intestinal parasites in a selected group of mental patients.
AU  - JEFFERY, G. M.
JO  - American Journal of Hygiene
JF  - American Journal of Hygiene
Y1  - 1960///
VL  - 71
IS  - 1
SP  - 1
EP  - 8
AD  - JEFFERY, G. M.: Department of Health, Education and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, P.O. Box 717, Columbia, South Carolina, U.S.A.
N1  - Accession Number: 19600800985. Publication Type: Journal Article. Language: not specified. 
N2  - Incidence of parasites was studied over a three-year period in mental patients, 110 for the total duration with nine examinations, and 199 for varying duration with one to eight examinations. The incidence and persistence of hookworms, Strongyloides stercoralis and Trichuris trichiura are tabulated and discussed. During the early stages of the survey the patients were housed in an old dilapidated hospital; they were then transferred to a new modern building and the implication of improved sanitation studied. Transmission of hookworm ceased and that of S. stercoralis and T. trichiura was greatly reduced. Hookworm and T. trichiura persisted for the three-year period in most cases. [No mention is made of treatment.] N. A. Hancock.
KW  - animal parasitic nematodes
KW  - developmental stages
KW  - helminths
KW  - hookworms
KW  - human diseases
KW  - incidence
KW  - mental retardation
KW  - nematode infections
KW  - parasites
KW  - sanitation
KW  - Ancylostomatidae
KW  - man
KW  - Strongyloides
KW  - Strongyloides stercoralis
KW  - Trichuris
KW  - Trichuris trichiura
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Strongyloididae
KW  - Strongyloides
KW  - Trichuridae
KW  - Trichuris
KW  - Adenophorea
KW  - Enoplida
KW  - growth phase
KW  - intestinal parasites
KW  - mental deficiency
KW  - mentally handicapped
KW  - parasitic worms
KW  - Rhabditida
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - The prophylactic and curative activity of 1-maleinyl-4-(3'-chloro-4'-methyl-phenyl)-piperazine (Hoechst S 688)in experimental schistosome infections.
AU  - LUTTERMOSER, G. W.
AU  - BRUCE, J. I.
AU  - MCMULLEN, D. B.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1960///
VL  - 9
IS  - 1
SP  - 39
EP  - 45
SN  - 0002-9637
AD  - LUTTERMOSER, G. W.: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, N.I.H., P.H.S., U.S. Department of Health, Education & Welfare, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610802750. Publication Type: Journal Article. Language: not specified. 
N2  - Luttermoser et al. have tested the prophylactic and curative activity of 1-maleinyl-4-(3'-chloro-4'-methyl-phenyl)-piperazine sodium salt (Hoechst S 688) against experimental infections of Schistosoma mansoni in mice and monkeys and S. japonicum in dogs. Treatment of S. mansoni in monkeys with 240 mg. per kg. body-weight of S 688 for two days was successful but approached toxic levels. 10 mg. per kg. of the drug given once daily for five days did not affect S. japonicum in a dog. 72 mg. per kg. or 120 mg. per kg. of S 688 given to mice up to 72 hours after exposure to S. mansoni cercariae brought about a significant reduction in worm burdens compared with those of control mice; this was not observed for monkeys. Slight prophylactic activity of the drug was observed in preventing the development of S. japonicwn in dogs given the drug for three days following exposure to cercariae. These findings are in agreement with those of Lámmler [for abstract see Helm. Abs., 27, No. 317a]. J. W. Smith.
KW  - cercariae
KW  - control
KW  - experimental infections
KW  - infections
KW  - prophylaxis
KW  - rodent control
KW  - dogs
KW  - mice
KW  - monkeys
KW  - Schistosoma
KW  - Schistosoma japonicum
KW  - Schistosoma mansoni
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - small mammals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Primates
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Schistosoma
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Unsaponifiable lipids of Taenia taeniaeformis and Moniezia sp.
AU  - THOMPSON, M. J.
AU  - MOSETTIG, E.
AU  - VON BRAND, T.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1960///
VL  - 9
IS  - 2
SP  - 127
EP  - 130
PB  - New York
SN  - 0014-4894
AD  - THOMPSON, M. J.: Laboratory of Chemistry, National Institutes of Health, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610800396. Publication Type: Journal Article. Language: not specified.  Registry Number: 57-88-5.
N2  - Thompson et al. found that cholesterol formed 98% and 85% of the unsaponifiable material from Taenia taeniaeformis and Moniezia sp. respectively. Friedelin was not found. 7-ketocholesterol which was formed during the isolation and storage of the unsaponifiable material, was obtained from Moniezia, but was absent from unsaponifiable material from T. taeniaeformis. W. P. Rogers.
KW  - cholesterol
KW  - storage
KW  - Anoplocephalidae
KW  - Moniezia
KW  - Taenia
KW  - Taenia taeniaeformis
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anoplocephalidae
KW  - Taeniidae
KW  - Taenia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - The effects of low concentrations of sodium pentachlorophenate on the fecundity and egg viability of Australorbis glabratus.
AU  - OLIVIER, L.
AU  - HASKINS, W. T.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1960///
VL  - 9
IS  - 2
SP  - 199
EP  - 205
SN  - 0002-9637
AD  - OLIVIER, L.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19600802032. Publication Type: Journal Article. Language: not specified.  Registry Number: 131-52-2.
N2  - Tests of the effect of sodium pentachlorophenate in concentrations of 0.05 and 0.1 p.p.m. on egg-laying and the viability of the eggs of Australorbis glabratus were performed in the laboratory. The tests lasted for seven to eight days after which the water was changed and replaced with untreated water to show possible recovery of egg production and viability. Withdrawal of the chemical was followed by greater egg-laying activity and increased viability. The lower concentration was found to be rather too low, the effect of 0.1 p.p.m. being very much better. W. K. Dunscombe.
KW  - aquatic animals
KW  - egg production
KW  - fecundity
KW  - freshwater molluscs
KW  - sodium pentachlorophenoxide
KW  - Biomphalaria
KW  - Biomphalaria glabrata
KW  - Mollusca
KW  - snails
KW  - Planorbidae
KW  - Gastropoda
KW  - Mollusca
KW  - invertebrates
KW  - animals
KW  - snails
KW  - aquatic animals
KW  - aquatic organisms
KW  - eukaryotes
KW  - Biomphalaria
KW  - PCP-Na
KW  - sodium pentachlorophenate
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Aquatic Biology and Ecology (MM300)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Observations on function, composition, and structure of cestode calcareous corpuscles.
AU  - ON BRAND, T.
AU  - MERCADO, T. I.
AU  - NYLEN, M. U.
AU  - SCOTT, D. B.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1960///
VL  - 9
IS  - 3
SP  - 205
EP  - 14
PB  - New York
SN  - 0014-4894
AD  - ON BRAND, T.: U.S. Depart ment of Health, Education and Welfare, PHS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19610802674. Publication Type: Journal Article. Language: not specified.  Registry Number: 124-38-9, 7439-95-4.
N2  - Von Brand et al. found that the calcareous corpuscles in Taenia taeniaeformis (3.1% of the fresh weight) and Cysticercus fasciolaris (6.9%) yielded on analysis, calcium, magnesium, phosphorus and carbon dioxide. Only small amounts of nitrogen were present (0.3% in corpuscles of T. taeniaeformis) and it is possible that 15% of the weight of the corpuscles was due to a rather easily volatilized inorganic compound. Crystalline material could not be detected by X-ray diffraction or by electron microscopy. The lamellae in the corpuscles seem to be made up of paired membranous rings. Histochemical tests, in addition to revealing the inorganic material, showed that the corpuscles contained polysaccharide, a muco-polysaccharide and proteins. Metabolic experiments indicated that the corpuscles serve to buffer acids entering from the medium and also, possibly, to protect the parasites against acids produced within their own tissues. W. P. Rogers.
KW  - carbon dioxide
KW  - magnesium
KW  - parasites
KW  - polysaccharides
KW  - X ray diffraction
KW  - Cestoda
KW  - Taenia
KW  - Taenia taeniaeformis
KW  - Taeniidae
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Taenia
KW  - complex carbohydrates
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - GEN
T1  - Catalogue of arthropod-borne viruses of the world. A collection of data on registered arthropod-borne animal viruses.
AU  - TAYLOR, Richard M.
T2  - Catalogue of arthropod-borne viruses of the world. A collection of data on registered arthropod-borne animal viruses.
Y1  - 1967///
PB  - U.S. Government Printing Office, Washington, D.C. 20402.
AD  - TAYLOR, Richard M.: Bethesda: National Institutes of Health, Maryland 20014, U.S.A.
N1  - Accession Number: 19692900279. Publication Type: Book. Language: not specified. 
N2  - See Abstr. Hyg., 1968, v. 43, p. 1397.
KW  - animal diseases
KW  - animal viruses
KW  - human diseases
KW  - vector-borne diseases
KW  - viral diseases
KW  - arthropods
KW  - man
KW  - viruses
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19692900279&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - gha
ER  - 

TY  - GEN
T1  - Some observations on the transmission of simian malaria.
AU  - COLLINS, W. E.
T2  - Proceedings. New Jersey Mosquito Extermination Association, 1969
JO  - Proceedings. New Jersey Mosquito Extermination Association, 1969
JF  - Proceedings. New Jersey Mosquito Extermination Association, 1969
Y1  - 1969///
SP  - 152
EP  - 158
AD  - COLLINS, W. E.: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Chamblee, Georgia 30341, USA.
N1  - Accession Number: 19721000443. Publication Type: Conference paper. Language: not specified. 
N2  - Malaria parasites from non-human primates can serve as laboratory models for the study of human parasites. P. knowlesi and P. coatneyi are in some respects biologically similar to P. falciparum, P. cynomolgi bastianellii to P. vivax, P. fieldi to P. ovale and P. inui to P. malariae. Results are given of studies on the infection of five species of Anopheles with the five simian parasites [cf. 55 565; 58 6, 338, 1139, etc.]. A. balabacensis balabacensis Baisas and A. maculatus Theo, transmitted P. cynomolgi by bite. A. b. balabacensis was the only Anopheline tested that could transmit all five species of Plasmodium.
KW  - infections
KW  - malaria
KW  - parasites
KW  - Anopheles
KW  - Anopheles balabacensis
KW  - Anopheles maculatus
KW  - Culicidae
KW  - man
KW  - monkeys
KW  - Plasmodium
KW  - Plasmodium cynomolgi
KW  - Plasmodium falciparum
KW  - Plasmodium knowlesi
KW  - Plasmodium malariae
KW  - Plasmodium ovale
KW  - Plasmodium vivax
KW  - Primates
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Plasmodium
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000443&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Observations on the development of Trypanosoma rangeliin the hemocoel of Rhodnius prolixus.
AU  - TOBIE, E. J.
JO  - Journal of Invertebrate Pathology
JF  - Journal of Invertebrate Pathology
Y1  - 1970///
VL  - 15
IS  - 1
SP  - 118
EP  - 125
SN  - 0022-2011
AD  - TOBIE, E. J.: Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19721000980. Publication Type: Journal Article. Language: English. Number of References: 14 ref.
KW  - Rhodnius
KW  - Rhodnius prolixus
KW  - Trypanosoma
KW  - Triatominae
KW  - Reduviidae
KW  - Heteroptera
KW  - Hemiptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Rhodnius
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Plants used against cancer. A survey [continued].
AU  - Hartwell, J. L.
JO  - Lloydia
JF  - Lloydia
Y1  - 1971///
VL  - 34
IS  - 4
SP  - 386
EP  - 438
AD  - Hartwell, J. L.: National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19720301713.  Publication Type: Journal Article.  Language: English.  Number of References: many ref. Subject Subsets: Horticultural Science
N2  - This final part of the series covers members of the Verbenaceae to the Zygophyllaceae, in alphabetical order, and also mosses, liverworts, algae, lichens, fungi and bacteria. [For previous part see HcA 42, 6720.].
KW  - lichens
KW  - medicinal plants
KW  - medicinal properties
KW  - surveys
KW  - USA
KW  - algae
KW  - bacteria
KW  - fungi
KW  - liverworts
KW  - mosses
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - eukaryotes
KW  - prokaryotes
KW  - Bryophyta
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - United States of America
KW  - Plant Science (General) (FF000) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of ageing on amino acid turnover and rate of protein synthesis in the blowfly Phormia regina.
AU  - LEVENBOOK, L.
AU  - KRISHNA, I.
JO  - Journal of Insect Physiology
JF  - Journal of Insect Physiology
Y1  - 1971///
VL  - 17
IS  - 1
SP  - 9
EP  - 12
SN  - 0022-1910
AD  - LEVENBOOK, L.: Laboratory of Physical Biology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19721001322. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 57-50-1.
N2  - Larvae of Phormia regina (Mg.) were reared on horsemeat and adults fed on sucrose and water in an insectary at 24°C, 70-75% R.H. and 14 h of illumination of about 10 ft-candles per day. Young adults 5 to 6 days old and aged flies 37 to 40 days old were selected for comparative study. Groups of four young flies and four aged flies from three consecutive generations were injected with alanine labelled with 14C, and comparable groups from two of the three generations were injected with lysine labelled with 14C. Each insect was injected with the same amount of one or the other of the labelled amino acids in neutral, aqueous solution, and after intervals of 30, 60, 90 or 120 min individual flies were analysed for total free pool of the injected amino acid, total counts in this pool, total protein, and counts in the entire protein alanine or lysine, according to which was injected. The results showed no significant difference between young and old flies in the size of their respective free alanine and lysine pools. The turnover rates of both free alanine and lysine were lower in aged as compared with young flies. The protein content of aged flies was about 86% of that of young flies. The protein lysine content remained constant with age (1.40 µmoles/fly), but the protein alanine content of young flies (1.45 µmoles/fly) was higher than that of old flies (1.21 µmoles/fly). The rates of incorporation of both alanine and lysine into protein were significantly lower in old flies than in young ones.
KW  - larvae
KW  - protein content
KW  - protein synthesis
KW  - sucrose
KW  - Phormia
KW  - Phormia regina
KW  - Calliphoridae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Phormia
KW  - protein biosynthesis
KW  - saccharose
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - The use of hypodermic needles as scalpels for insect micro-dissection.
AU  - BURTON, G. J.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1971///
VL  - 31
IS  - 1
SP  - 113
EP  - 114
AD  - BURTON, G. J.: National Cancer Institute Building 37, National Institute of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19721000050. Publication Type: Journal Article. Language: English. 
KW  - entomology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Insect aspirators made from plastic or glass serological pipettes.
AU  - BURTON, G. J.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1971///
VL  - 31
IS  - 2
SP  - 220
EP  - 220
AD  - BURTON, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19721000590. Publication Type: Journal Article. Language: not specified. Language of Summary: English. 
KW  - entomology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - A simple inexpensive styrofoam chamber for long-term holding of adult mosquitoes.
AU  - BURTON, G. J.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1971///
VL  - 31
IS  - 2
SP  - 220
EP  - 221
AD  - BURTON, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19721000591. Publication Type: Journal Article. Language: English. 
N2  - If an insectary with controlled temperature and humidity is not available, mosquitos can be kept alive for up to 1-2 months, depending on the species, in humidity chambers constructed from styrofoam insulated boxes. The method, which is described, has been used successfully for the maintenance of adults of Anopheles quadrimaculatus Say, A. stephensi List., Aedes aegypti (L.) and Culex pipiens pipiens L. infected with murine leukaemia virus for long periods.
KW  - humidity
KW  - leukaemia
KW  - methodology
KW  - techniques
KW  - temperature
KW  - Aedes
KW  - Aedes aegypti
KW  - Anopheles
KW  - Anopheles quadrimaculatus
KW  - Anopheles stephensi
KW  - Culex
KW  - Culex pipiens
KW  - Culex pipiens pipiens
KW  - Culicidae
KW  - viruses
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Aedes
KW  - Anopheles
KW  - Culex
KW  - Culex pipiens
KW  - blood cancer
KW  - leucaemia
KW  - leukemia
KW  - methods
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600)
KW  - Techniques and Methodology (ZZ900)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Primary cultures of tick hemocytes as systems for arbovirus growth.
AU  - CORY, J.
AU  - YUNKER, C. E.
JO  - Annals of the Entomological Society of America
JF  - Annals of the Entomological Society of America
Y1  - 1971///
VL  - 64
IS  - 6
SP  - 1249
EP  - 1254
SN  - 0013-8746
AD  - CORY, J.: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19721001156. Publication Type: Journal Article. Language: English. Number of References: 13 ref.
N2  - The following is virtually the authors' abstract. Primary cultures of haemocytes of Dermacentor andersoni Stiles were maintained in viable condition for 72-74 days as judged by their ability to support the growth of Colorado tick fever virus [cf. RAE B 59 306]. Virus-growth curves for these cultures were similar to those for primary tissue cultures of viscera of D. andersoni except that peak virus proliferation and the duration of the infection were not as pronounced. Cultures of tick haemocytes offer a relatively simple and rapid alternative to tissue cultures prepared from tick viscera.
KW  - growth
KW  - haemocytes
KW  - infections
KW  - Colorado tick fever virus
KW  - Dermacentor
KW  - Dermacentor andersoni
KW  - Ixodidae
KW  - viruses
KW  - Orbivirus
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Dermacentor
KW  - hemocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Observations on Trichopteran predators of aquatic stages of Simulium damnosum and other Simulium species in Ghana.
AU  - Burton, G. J.
AU  - McRae, T. M.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1972///
VL  - 9
IS  - 4
SP  - 289
EP  - 294
SN  - 0022-2585
AD  - Burton, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19720500885.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Eggs, larvae and pupae of Sumulium damnosum Theo. from breeding sites in the Red Volta, White Volta and Volta rivers in Ghana were kept in the laboratory with larvae of Hydropsyche, Cheumatopsyche and Chimarra, the commonest Trichopteran larvae found in the breeding sites. No ingestion of eggs, pupae or attached larvae of Simulium was observed, but motile larvae were attacked and eaten when they touched the nets constructed by the larvae of Hydropsyche and Cheumatopsyche. Only one such attack by larvae of Chimarra was observed. The remains of Simuliid larvae were found in 5 of 50 larvae of Hydropsyche taken from the Volta rivers, in 3 of 25 larvae of Cheumatopsyche and none of 15 larvae of Chimarra. In the Dayi river in eastern Ghana, a larva of Orthotrichia was seen feeding on a pupa of S. garmsi brosskey (alcocki occidentale Freeman & De Meillon) and one of S. schoutedeni Wns. A summary of reported predation of Simuliids by Trichopteran larvae is included.
KW  - natural enemies
KW  - predators
KW  - prey
KW  - Ghana
KW  - Diptera
KW  - Hydropsyche
KW  - Simuliidae
KW  - Simulium damnosum
KW  - Simulium schoutedeni
KW  - Trichoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Hydropsychidae
KW  - Trichoptera
KW  - Diptera
KW  - Simulium
KW  - Simuliidae
KW  - aquatic animals
KW  - aquatic organisms
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - blackflies
KW  - buffalo gnats
KW  - Cheumatopsyche
KW  - Chimarra
KW  - Orthotrichia
KW  - Philopotamidae
KW  - Simulium garmsi
KW  - Animal Behaviour (LL300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phoretic attachment of Simulium larvae and pupae to mayfly and dragonfly nymphs.
AU  - Burton, G. J.
AU  - McRae, T. M.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1972///
VL  - 32
IS  - 3
SP  - 436
EP  - 443
AD  - Burton, G. J.: National Cancer Institute, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19720501182.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - In the Red Volta River near Bolgalanga, Ghana, a complete pupa of Simulium adersi Pomeroy was found attached to the wing pad of a nymph of the dragonfly Zygonyx torrida (Kby.) and an empty cocoon of the same Simuliid was found attached to the head of another nymph; on a dam spillway east of Gambaga, a deteriorated pupa of S. hargreavesi Gibbins was found attached to the wing pad of a third nymph. The literature on the phoretic attachment of larvae and pupae of Simuliids to the nymphs of Odonata and Ephemeroptera is reviewed.
KW  - pupae
KW  - Ghana
KW  - Diptera
KW  - Simuliidae
KW  - Simulium adersi
KW  - Simulium hargreavesi
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Diptera
KW  - Simulium
KW  - Simuliidae
KW  - Aeshnidae
KW  - Odonata
KW  - aquatic animals
KW  - aquatic organisms
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - attached to nymphs of Zygonyx torrida in Ghana
KW  - blackflies
KW  - buffalo gnats
KW  - Simulium bargreavesi
KW  - Simulium pupae attached to numphs of, in Ghana
KW  - Zygonyx
KW  - Zygonyx torrida
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Experimental transmission of Toxoplasma gondii by cockroaches.
AU  - Wallace, G. D.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1972///
VL  - 126
IS  - 5
SP  - 545
EP  - 547
SN  - 0022-1899
AD  - Wallace, G. D.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Honolulu, Hawaii.
N1  - Accession Number: 19730510192.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Leucophaea maderae (F.) and Periplaneta americana (l.) were evaluated as transport hosts of Toxoplasma gondii. After starved cockroaches were allowed access to feline faeces containing infective oocysts of Toxoplasma, their faeces and digestive tracts were tested for infectivity in mice. T. gondii was isolated from the digestive tract of cockroaches for up to 7 days after they had contact with feline faeces and from cockroach faeces for up to 9 to 10 days after contact. Cockroach faeces that were stored at room temperature (about 25 deg C) and humidity (66-78% R.H.) remained infective for mice for up to 17 days.
KW  - disease transmission
KW  - transmission
KW  - Blattaria
KW  - Periplaneta americana
KW  - Pycnoscelus
KW  - RHYPAROBIA MADERAE
KW  - Toxoplasma gondii
KW  - Blattaria
KW  - Dictyoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Periplaneta
KW  - Blattidae
KW  - Oxyhaloidae
KW  - Rhyparobia
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - Pycnoscelus
KW  - American cockroach
KW  - Blattodea
KW  - Leucophaea
KW  - Leucophaea maderae
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epizootiology of Venezuelan equine encephalomyelitis in the Americas.
AU  - Walton, T. E.
AU  - Johnson, K. M.
JO  - Journal of the American Veterinary Medical Association
JF  - Journal of the American Veterinary Medical Association
Y1  - 1972///
VL  - 161
IS  - 11
SP  - 1509
EP  - 1515
SN  - 0003-1488
AD  - Walton, T. E.: Middle America Research Unit, National Institute of Allergy and Infectious Diseases, Balboa Heights, Panama Canal Zone.
N1  - Accession Number: 19730505452.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2  - This review includes published and unpublished information up to 1972.
KW  - America
KW  - Central America
KW  - North America
KW  - South America
KW  - USA
KW  - Culicidae
KW  - Diptera
KW  - equine encephalomyelitis virus
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Alphavirus
KW  - Togaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - mosquitoes
KW  - United States of America
KW  - Venezuelan equine encephalitis
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A simple tissue press for initiating cell cultures from mosquito eggs, larvae, pupae, or adults or their organs.
AU  - BURTON, G. J.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1972///
VL  - 32
IS  - 1
SP  - 112
EP  - 113
AD  - BURTON, G. J.: National Cancer Institute, National Institutes of Health. Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19721001658. Publication Type: Journal Article. Language: English. Number of References: 12 ref.
KW  - cell cultures
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001658&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Transmission of Plasmodium falciparum from monkey to monkey by the bite of infected Anopheles free borni mosquitoes.
AU  - COLLINS, W. E.
AU  - CONTACOS, P. G.
JO  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF  - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1  - 1972///
VL  - 66
IS  - 2
SP  - 371
EP  - 372
AD  - COLLINS, W. E.: Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Chamblee, Georgia 30341, USA.
N1  - Accession Number: 19721001316. Publication Type: Journal Article. Language: English. Number of References: 5 ref.
KW  - bites
KW  - Anopheles
KW  - Culicidae
KW  - monkeys
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Plasmodium
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - Feeding of Simulium hargreavesi Gibbins larvae on Oedegonium algal filaments in Ghana.
AU  - Burton, G. J.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1973///
VL  - 10
IS  - 1
SP  - 101
EP  - 106
SN  - 0022-2585
AD  - Burton, G. J.: National Cancer Institute, Landlow Building, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19730505519.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - On a dam spillway of earth and rocks at Nalerigu, in the Northern Region of Ghana, huge numbers of larvae of Simulium hargreavesi Gibbins were found feeding exclusively by grazing on filaments of the green algae Oedogonium inconspicuum and O. moniliforme and on organic debris trapped among the filaments. More than 200 larvae were dissected and the contents of the mid-gut examined. The narrower species, O. inconspicuum (3.4-5 mu m in diameter), was found in the gut in pieces 100-1500 mu m long, mostly in the 165-500 mu m range. The pieces of the wider species, O. moniliforme (8.5-10 mu m in diameter), in the gut ranged in length from 65-1000 mu m, but those over 500 mu m were few. The findings by other investigators of Simuliid larvae feeding on filamentous algae are reviewed, together with reported deterrent effects of such algae. The possibilities of control of grazing species through absorption, adsorption and residual retention of insecticides by the filaments are also discussed. The appearance of the masses of larvae on the filaments and the two species of Oedogonium from dissected larvae are illustrated by photographs.
KW  - Ghana
KW  - Diptera
KW  - Simuliidae
KW  - Simulium hargreavesi
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Diptera
KW  - Simulium
KW  - Simuliidae
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - blackflies
KW  - buffalo gnats
KW  - Oedogonium
KW  - Oedogonium inconspicuum
KW  - Oedogonium moniliforme
KW  - Simulium hargreavesi feeding
KW  - Animal Behaviour (LL300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intermediate and transport hosts in the natural history of Toxoplasma gondii.
AU  - Wallace, G. D.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1973///
VL  - 22
IS  - 4
SP  - 456
EP  - 464
SN  - 0002-9637
AD  - Wallace, G. D.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii.
N1  - Accession Number: 19730586080.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Studies were carried out on rodents, birds, geckos and a cockroach as intermediate or transport hosts of Toxoplasma gondii, a protozoan parasite, the only definitive hosts of which appear to be Felids as this is the only group of animals in which the resistant oocyte stage develops. In experiments with Leucophaea maderae (F.), the starved cockroaches were given access to cat faeces known to contain sporulated oocysts for 5 days. Viable oocysts were found to be harboured in the digestive tract of the cockroaches, when they were starved, for up to 20 days, but not for 27 or 34 days, after the infective feed.
KW  - persistence
KW  - Blattaria
KW  - Pycnoscelus
KW  - RHYPAROBIA MADERAE
KW  - Toxoplasma gondii
KW  - Blattaria
KW  - Dictyoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Oxyhaloidae
KW  - Rhyparobia
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - Pycnoscelus
KW  - Blattodea
KW  - Leucophaea
KW  - Leucophaea maderae
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - A potential antileukemic substance present in Allium ascalonicum.
AU  - Caldes, G.
AU  - Prescott, B.
JO  - Planta Medica
JF  - Planta Medica
Y1  - 1973///
VL  - 23
IS  - 1
SP  - 99
EP  - 100
SN  - 0032-0943
AD  - Caldes, G.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19730307359.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Horticultural Science
N2  - Aqueous extracts of shallot bulbs, having antileukemic activity, had a high concentration of carbohydrates and a full spectrum of amino acids on hydrolysis.
KW  - amino acids
KW  - bulbs
KW  - carbohydrates
KW  - composition
KW  - medicinal plants
KW  - shallots
KW  - vegetables
KW  - Alliaceae
KW  - Allium ascalonicum
KW  - Allium cepa var. aggregatum
KW  - Liliales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Allium
KW  - Alliaceae
KW  - Liliaceae
KW  - Allium cepa
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - saccharides
KW  - vegetable crops
KW  - Plant Composition (FF040) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mosquito rearing and sorting chambers made from eggshells and egg containers.
AU  - Burton, G. J.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1973///
VL  - 33
IS  - 1
SP  - 108
EP  - 110
AD  - Burton, G. J.: National Cancer Institute, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19730507950.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Medical & Veterinary Entomology
N2  - Methods of adapting egg-shells and egg containers for use as rearing units for mosquito larvae are described. The top of the egg is cut off, and a miniature emergence cage is fixed over the opening by means of an expanded key ring. The lids of egg containers can be used to sort mosquito catches.
KW  - apparatus
KW  - rearing techniques
KW  - Culicidae
KW  - Diptera
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - mosquitoes
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aerobic bacteria in the midgut of Simulium damnosum larvae.
AU  - Burton, G. J.
AU  - Perkins, I. V.
AU  - Sodhi, H. S.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1973///
VL  - 33
IS  - 1
SP  - 115
EP  - 117
AD  - Burton, G. J.: National Cancer Institute, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19730507954.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Animal Nutrition; Medical & Veterinary Entomology
N2  - The mid-gut contents of 20 mature larvae of Simulium damnosum Theo. collected in the Upper Region of Ghana were cultured in simple media to determine the numbers and kinds of aerobic bacteria present. Species of Azotobacteraceae were present in all larvae, those of Bacillaceae in 7 and those of Micococcaceae and Pseudomoadaceae in 1 each. The numbers of colonies of aerobic bacteria after incubation for 2 days at 25 deg C ranged from 89 000 to 4 million in cultures from 10 other larvae. Fungi were also present.
KW  - Ghana
KW  - Diptera
KW  - Simuliidae
KW  - Simulium damnosum
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Diptera
KW  - Simulium
KW  - Simuliidae
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - aerobic bacteria
KW  - blackflies
KW  - buffalo gnats
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The hypothesis of extrahuman reservoirs of Rickettsia prowazekii.
AU  - Ormsbee, R. A.
JO  - Scientific Publication, Pan American Health Organization
JF  - Scientific Publication, Pan American Health Organization
Y1  - 1973///
IS  - 263
SP  - 104
EP  - 109
AD  - Ormsbee, R. A.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19740514125.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - reservoirs
KW  - Anoplura
KW  - Rickettsia prowazekii
KW  - Phthiraptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - water reservoirs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Possible extrahuman reservoirs of Rickettsia prowazekii: ticks [including species of Amblyomma, Hyalomma, Dermacentor and Ornithodoros].
AU  - Burgdorfer, W.
JO  - Scientific Publication, Pan American Health Organization
JF  - Scientific Publication, Pan American Health Organization
Y1  - 1973///
IS  - 263
SP  - 109
EP  - 113
AD  - Burgdorfer, W.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19740514126.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - reservoirs
KW  - Acari
KW  - Amblyomma
KW  - Dermacentor
KW  - Hyalomma
KW  - Ornithodoros
KW  - Rickettsia prowazekii
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Argasidae
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - water reservoirs
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rickettsial plaques in mosquito cell monolayers.
AU  - Cory, J.
AU  - Yunker, C. E.
JO  - Acta Virologica
JF  - Acta Virologica
Y1  - 1974///
VL  - 18
IS  - 6
SP  - 512
EP  - 513
SN  - 0001-723X
AD  - Cory, J.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 50840, USA.
N1  - Accession Number: 19750526130.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2  - Well defined plaques were obtained from two spotted fever group rickettsiae, Rickettsia rickettsi and R. conori, in Singh's lines of cells of Aedes albopictus (Skuse).
KW  - cell lines
KW  - mosquito nets
KW  - Tissue culture
KW  - Aedes
KW  - Aedes albopictus
KW  - Culicidae
KW  - Diptera
KW  - Rickettsia conorii
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Aedes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Asian tiger mosquito
KW  - bacterium
KW  - mosquitoes
KW  - plaque formation
KW  - Rickettsia conori
KW  - Rickettsia conoriin
KW  - Rickettsia rickettsi
KW  - Other Control Measures (HH700) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Scorpion toxin-induced catecholamine release from synaptosomes.
AU  - Moss, J.
AU  - Colburn, R. W.
AU  - Kopin, I. J.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1974///
VL  - 22
IS  - 2
SP  - 217
EP  - 221
SN  - 0022-3042
AD  - Moss, J.: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19750526117.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 51-40-1, 51-41-2, 69815-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - A toxin purified from crude venom of the scorpion L[eiurus] quinquestriatus (Hemprich & Ehrenberg) released norepinephrine from synaptosomes prepared from rat brain. The toxin-induced release was dependent on duration of exposure and concentration of toxin in the medium.
KW  - norepinephrine
KW  - venoms
KW  - Arachnida
KW  - Leiurus quinquestriatus
KW  - RATS
KW  - Scorpiones
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leiurus
KW  - Buthidae
KW  - Scorpiones
KW  - Arachnida
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - inducing release of catecholamines from synaptosomes
KW  - noradrenaline
KW  - rat brain synaptosomes
KW  - venom
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Zoonotic potential (Rocky Mountain spotted fever and tularemia) in the Tennessee Valley region. II. Prevalence of Rickettsia rickettsi and Francisella tularensis in mammals and ticks from Land Between the Lakes.
AU  - Burgdorfer, W.
AU  - Cooney, J. C.
AU  - Thomas, L. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1974///
VL  - 23
IS  - 1
SP  - 109
EP  - 117
SN  - 0002-9637
AD  - Burgdorfer, W.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19740514055.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science
N2  - A survey was conducted from July 1969 to January 1972 in Land Between the Lakes, an outdoor recreation and conservation education area in the Tennessee Valley region, to determine the occurrence of Rickettsia rickettsi and Pasteurella (Francisella) tularensis, the agents of spotted fever and tularaemia, respectively, in wild mammals and their ticks (cf. preceeding abstract]. Serological evidence suggested that both pathogens are widely distributed among a large variety of medium-sized mammals throughout the area. Fifty-five of 666 sera (from 8 of the 22 species of mammals sampled had complement-fixing antibodies to spotted fever antigens, with sera from cottontail rabbits (32 of 66 examples), raccoons (8 of 163) and woodchucks (6 of 49) giving the largest number of positive reactions. Antibodies to tularaemia were detected in 117 of 620 sera, with the highest prevalence among striped skunks (11 of 16), grey foxes (37 of 72), raccoons (73 of 161) and woodchucks (17 of 48).Dermacentor variabilis (Say) was the only species of tick from which R. rickettsi and P. tularensis were isolated. Of 931 adults collected off host animals or by dragging, 51 were infected with R. rickettsi; 39 of these yielded strains pathogenic for laboratory animals. Seven ticks, two of them also infected with R. rickettsi, contained P. tularensis. An unidentified bacterium-like micro-organism was detected in the haemolymph of 80 examples of D. variabilis. This organism appeared unrelated to rickettsiae and proved non-pathogenic for meadow voles. A rickettsia-like organism antigenically related to the spotted fever group was noted in 64 of 545 examples of Amblyomma americanum (L.); it also failed to produce detectable infection or antibodies to spotted fever group antigens in meadow voles.
KW  - animal diseases
KW  - infections
KW  - rickettsial diseases
KW  - Rocky Mountain spotted fever
KW  - tularaemia
KW  - wild animals
KW  - wildlife
KW  - Zoonoses
KW  - Kentucky
KW  - Tennessee
KW  - USA
KW  - Acari
KW  - Amblyomma americanum
KW  - canidae
KW  - dermacentor
KW  - Dermacentor variabilis
KW  - FRANCISELLA TULARENSIS
KW  - lagomorpha
KW  - mammals
KW  - Marmota monax
KW  - Mephitis mephitis
KW  - METASTIGMATA
KW  - Procyon lotor
KW  - Rickettsia rickettsii
KW  - Rickettsiales
KW  - Sylvilagus floridanus
KW  - Urocyon
KW  - Urocyon cinereoargenteus
KW  - Vulpes
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Amblyomma
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Dermacentor
KW  - Francisella
KW  - Francisellaceae
KW  - Thiotrichales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Marmota
KW  - Sciuridae
KW  - rodents
KW  - Mephitis
KW  - Mustelidae
KW  - Procyon
KW  - Procyonidae
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Sylvilagus
KW  - Leporidae
KW  - Lagomorpha
KW  - Canidae
KW  - Urocyon
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - USA
KW  - East South Central States of USA
KW  - bacterium
KW  - Ixodoidea
KW  - lone star tick
KW  - Pasteurella tularensis
KW  - Rickettsia rickettsi
KW  - ticks
KW  - tularemia
KW  - United States of America
KW  - variabilis
KW  - VULPES CINEREOARGENTEUS
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biological Resources (Animal) (PP710) 
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ER  - 

TY  - JOUR
T1  - Development of Plasmodium vivax in chemosterilized Anopheline mosquitoes.
AU  - Omar, M. S.
AU  - Collins, W. E.
AU  - Gwadz, R. W.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1974///
VL  - 23
IS  - 3
SP  - 334
EP  - 338
SN  - 0002-9637
AD  - Omar, M. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30341, USA.
N1  - Accession Number: 19740517359.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Studies were carried out to determine the effect of pupal chemosterilisation on the susceptibility of the resulting adults of Anopheles albimanus Wied. and A. freeborni Aitken to infection with Plasmodium vivax. The mosquitos were sterilised by exposing pupae for 1, 2 or 4 h in 1% aqueous solution of ENT-61585 (P,P-bis(1-aziridinyl)-N-methylphosphinothioic amide). Complete sterility resulted from treatment for 1 h in the case of males and females of A. albimanus and males of A. freeborni, but virtually complete sterility was only achieved after exposure for 4 h in the case of females of A. freeborni. The difference in susceptibilty to P. vivax between sterilised and normal mosquitos was more pronounced in A. albimanus than in A. freeborni. The over-all infection rate of sterile females of A. albimanus was significantly less (26%) than that of untreated ones (69%). In the case of A. freeborni, however, a less marked effect was noticed, the corresponding figures being 56 and 75%. Sporogony was completed in sterilised mosquitos, motile sporozoites being found in the salivary glands.
KW  - chemosterilants
KW  - infectivity
KW  - mosquito nets
KW  - sterilants
KW  - Anopheles albimanus
KW  - Anopheles freeborni
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium vivax
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - phosphinothioic amide, P,P-bis(1-aziridinyl)-N-methyl-
KW  - Plasmodium susceptibility
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Studies on the antimalarial effects of RC-12 and WR 14,977 on the development of Plasmodium cynomolgi in mosquitoes and rhesus monkeys.
AU  - Omar, M. S.
AU  - Collins, W. E.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1974///
VL  - 23
IS  - 3
SP  - 339
EP  - 349
SN  - 0002-9637
AD  - Omar, M. S.: National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30341, USA.
N1  - Accession Number: 19740517360.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The activity of RC-12 (1,2-dimethoxy-4-(bis(2-(diethylamino)-ethyl)amino)-5-bromobenzene) and WR 14997 (1-aminocyclopentanecarboxylic acid) against gametocytes and the sporogonic cycle of Plasmodium cynomolgi was studied in Macaca mulatta and Anopheles maculatus Theo. The effect of the drugs on the mosquito stages of the parasite was assessed both after treatment by gavage of infected monkeys, on which the mosquitos were fed, and direct administration in sugar solution to infected mosquitos. Single or multiple doses of RC-12 at 25 mg/kg a day administered to the monkeys were equally effective against gametocytes and the sporogonic cycle of the parasite. Mosquito infection was interrupted within 8 to 24 h following initial treatment. The feeding of RC-12 at 0.1-1.0% in 10% sugar solution to infected mosquitos resulted in no discernible effects on oocyst development or sporozoite formation in the mosquito. The salivary glands of treated mosquitos displayed marked morpho-pathological alterations as a result of drug ingestion. Repeated daily doses of WR 14997 at 60 mg/kg or 100 mg/kg administered to the monkeys had no significant gametocidal, sporontocidal or prophylactic activity against P. cynomolgi after being administered to the monkey host. In contrast, WR 14997 exhibited a marked sporontocidal action against the parasite when the drug was administered directly to the mosquitos.These results do not support the assumption that there is a correlation in drug response between the sporogonic cycle of the malaria parasite in the invertebrate host and the tissue stages of the same parasite in the vertebrate host when the drug is fed directly to the mosquito [cf. RAE/B 59, 445]. However, there apears to be a direct relationship between the effect of the drug on the gametocyte and tissue stages when it is administered to the vertebrate host prior to mosquito feeding.
KW  - antimalarials
KW  - mosquito nets
KW  - Anopheles maculatus
KW  - Culicidae
KW  - Diptera
KW  - Macaca mulatta
KW  - Plasmodium
KW  - Plasmodium cynomolgi
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Plasmodium
KW  - 1,2-ethanediamine, N-(2-bromo-4,5-dimethoxyphenyl)-N-[2-(diethylamino)ethyl]-N',N'-diethyl-
KW  - cyclopentanecarboxylic acid, 1-amino-
KW  - Haemosporida
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Other Control Measures (HH700) 
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ER  - 

TY  - JOUR
T1  - Differential uptake of tritiated thymidine and adenine by the mosquito Aedes aegypti infected with the filarial nematode Brugia pahangi.
AU  - Omar, M. S.
AU  - Gwadz, R. W.
JO  - Tropenmedizin und Parasitologie
JF  - Tropenmedizin und Parasitologie
Y1  - 1974///
VL  - 25
IS  - 2
SP  - 167
EP  - 174
AD  - Omar, M. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Chamblee, Georgia, USA.
N1  - Accession Number: 19740517896.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 16 ref. Registry Number: 50-89-5.  Subject Subsets: Medical & Veterinary Entomology; Helminthology
N2  - Little is known about the biochemical requirements of filarial nematodes developing in a mosquito host. An account is given of a study by means of autoradiography on tissue sections of the uptake and distribution of thymidine and adenine labelled with tritium fed to females of Aedes aegypti (L.) infected with Brugia pahangi. Massive incorporation of labelled thymidine was seen, primarily in the nuclei of dividing issues (ovary) as well as in non-dividing tissues (mid-gut) of the mosquito. Labelled adenine was homogeneously distributed over both cytoplasmic and nuclear regions of the ovary and mid-gut cells. Thymidine incorporation into nuclei of parasitised muscle fibres was not observed during the early stages of filarial development but coincided with the maturation and subsequent escape of filarial larvae from the muscles into the haemocoel. No thymidine was incorporated into developing individuals of B. pahangi, but a slight uptake of adenine was noted.
KW  - biochemistry
KW  - helminths
KW  - mosquito nets
KW  - nucleosides
KW  - parasites
KW  - thymidine
KW  - Aedes aegypti
KW  - Brugia
KW  - Brugia pahangi
KW  - Culicidae
KW  - Diptera
KW  - Insects
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Brugia
KW  - 1H-Purin-6-amine
KW  - adenine & thymidine uptake
KW  - mosquitoes
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phlebotomine sandflies in Montana: first report.
AU  - Chaniotis, B. N.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1974///
VL  - 34
IS  - 3
SP  - 334
EP  - 335
AD  - Chaniotis, B. N.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19740519952.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A male and 2 females of Lutzomyia vexator occidentis (Fairchild & Hertig) and a male and 3 females of L. oppidana (Dampf) were collected near Hamilton, Montana, in 1973. These are the first records of Phlebotomines from Montana.
KW  - Montana
KW  - USA
KW  - Diptera
KW  - Lutzomyia vexator
KW  - Phlebotominae
KW  - Psychodidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lutzomyia
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Mountain States of USA
KW  - Western States of USA
KW  - Lutzomyia oppidana
KW  - Lutzomyia vexator occidentis
KW  - United States of America
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Biological Resources (Animal) (PP710) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - National and regional health planning in Sweden.
AU  - NAVARRO, V.
T2  - DHEW Publication
Y1  - 1974///
IS  - (N1H) 74-240
AD  - NAVARRO, V.: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, U.S.A.
N1  - Accession Number: 19762702928. Publication Type: Book. Language: not specified. 
N2  - This monograph is recommended to anyone who is interested in studying the Swedish health system. The author provides a comprehensive account of health care planning and services in Sweden, beginning with an explanation of the Swedish governmental process at both national and local levels. In order to correct some of the damaging myths existing about Sweden's particular problems, such as suicide, Navarro concentrates on identifying some of the common health experiences shared by industrialized societies. For example, the cost of medical and hospital care has increased in most industrialized societies owing to technological innovation in the health sector and growing demands for services. Sweden's response to these rising costs in the 1960's was to regionalize hospital services and to promote " voluntarism " in health planning-that is, the principle of bringing together different groups and institutions on a voluntary basis to reach common objectives. By the 1970's, however, the emphasis in Sweden had moved towards strengthening the planning machinery at national level and integrating hospital services and general medical care with social services. Indeed, comparisons can be drawn between the recent British reorganization of health services, aimed at removing the tripartite structure, and the Swedish experience. The author touches on this comparison but, at the time his book was published, it would have been premature to engage in lengthier comparisons on this issue. Nevertheless, a little more depth analysis and less factual description would have enlivened this text. Even so, it gives an accurate and extremely useful picture of health care planning and services in Sweden, set clearly in the framework of the country's geographical, political and socio-economic characteristics. Rosamund M. Thomas.
KW  - comparisons
KW  - government
KW  - health services
KW  - medical services
KW  - monographs
KW  - planning
KW  - prematurity
KW  - social services
KW  - Sweden
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Health Services (UU350)
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DP  - EBSCOhost
DB  - gha
ER  - 

TY  - JOUR
T1  - In vitro biosynthesis of oothecal sclerotization agents from tyrosine by haemolymph of Periplaneta americana.
AU  - Lake, C. R.
AU  - Mills, R. R.
JO  - Insect Biochemistry
JF  - Insect Biochemistry
Y1  - 1975///
VL  - 5
IS  - 5
SP  - 659
EP  - 669
AD  - Lake, C. R.: Laboratory of Clinical Science, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19750530426.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 51-67-2, 60-18-4.  Subject Subsets: Medical & Veterinary Entomology
N2  - Whole haemolymph of adult females of Periplaneta americana (L.) was homogenised in distilled water and the extract subjected to column chromatography on Sepharose-6B. The partially purified enzyme, when incubated with the appropriate cofactors, was capable of catalysing several reactions. With pyridoxal-phosphate and NAD but without the addition of copper, L-tyrosine labelled with 14C was metabolised to tyramine, octopamine, p-hydroxymandelic acid, p-hydroxybenzaldehyde, p-hydroxybenzyl alcohol, p-hydroxybenzoic acid, p-hydroxyphenylpyruvic acid, p-hydroxyphenylacetic acid, p-hydroxyphenyllactic acid and p-hydroxyphenylpropionic acid. The major metabolites of L-tyramine labelled with 14C were octopamine, p-hydroxymandelic acid and p-hydroxybenzoic acid. Further experiments using the crude homogenate and unlabelled substrates showed that octopamine was metabolised to p-hydroxymandelic acid and that it produced p-hydroxybenzaldehyde, p-hydroxybenzoic acid and 3,4-dihydroxybenzoic acid (protocatechuic acid). The results suggest the following pathway exists for the synthesis of protocatechuic acid: tyrosine 'right arrow' tyramine 'right arrow' octopamine 'right arrow' p-hydroxymandelic acid 'right arrow' p-hydroxyphenylglyoxylic acid or p-hydroxybenzyl alcohol, or both, 'right arrow' p-hydroxybenzaldehyde 'right arrow' p-hydroxybenzoic acid 'right arrow' protocatechuic acid. Hydroxylation of the p-hydroxy compounds occurred in the presence of copper but at different rates. The initial transamination or deamination, or both, of tyrosine to the p-hydroxypyruvate is apparently not instrumental in the synthesis of protocatechuic acid although the results of this investigation do not offer conclusive evidence concerning this question.
KW  - metabolism
KW  - synthesis
KW  - tyramine
KW  - tyrosine
KW  - Blattaria
KW  - Periplaneta americana
KW  - Blattaria
KW  - Dictyoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Periplaneta
KW  - Blattidae
KW  - American cockroach
KW  - benzaldehyde, 4-hydroxy-
KW  - benzeneacetic acid, 4-hydroxy-
KW  - benzeneacetic acid, 4-hydroxy-alpha-oxo-
KW  - benzeneacetic acid,alpha,4-dihydroxy-
KW  - benzenemethanol, 4-hydroxy-
KW  - benzenemethanol, alpha-(aminomethyl)-4-hydroxy-
KW  - benzenepropanoic acid, 4-hydroxy-alpha-oxo-
KW  - benzenepropanoic acid,alpha,4-dihydroxy-
KW  - benzenepropanoic aicd, 4-hydroxy-
KW  - benzoic acid, 3,4-dihydroxy-
KW  - benzoic acid, 4-hydroxy-
KW  - Blattodea
KW  - sclerotising agents
KW  - synthesis from tyrosine
KW  - synthesis of sclerotising agents
KW  - tyrosine metabolite
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Animal Reproduction and Development (LL210) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Failure of rubella virus to replicate in mosquitoes.
AU  - Tesh, R. B.
AU  - Rosen, L.
JO  - Intervirology
JF  - Intervirology
Y1  - 1975///
VL  - 5
IS  - 3/4
SP  - 216
EP  - 219
SN  - 0300-5526
AD  - Tesh, R. B.: Pacific Research Station, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii, USA.
N1  - Accession Number: 19760534119.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Rubella virus failed to replicate in females of Aedes albopictus (Skuse) and Culex pipiens fatigans Wied. (C. fatigans) following parenteral inoculation. The virus was demonstrated in females tested immediately after inoculation but was not detected in those sampled 7, 14 and 21 days after inoculation. This experiment provides further evidence that rubella is not an arbovirus but does not invalidate its classification as a togavirus.
KW  - mosquito nets
KW  - Aedes albopictus
KW  - Culex pipiens
KW  - CULEX QUINQUEFASCIATUS
KW  - Culicidae
KW  - Diptera
KW  - rubella virus
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Culex
KW  - Rubivirus
KW  - Togaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Culex pipiens
KW  - Asian tiger mosquito
KW  - Culex pipiens fatigans
KW  - mosquitoes
KW  - not replicating
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Multiplication of Phlebotomus fever group arboviruses in mosquitoes after intrathoracic inoculation.
AU  - Tesh, R. B.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1975///
VL  - 12
IS  - 1
SP  - 1
EP  - 4
SN  - 0022-2585
AD  - Tesh, R. B.: National Institute of Allergy and Infectious Diseases, P.O. Box 1680, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19750527447.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Twenty-two arboviruses of the Phlebotomus fever group were inoculated intrathoracically into males and females of Aedes albopictus (Skuse) and Culex pipiens fatigans Wied. (C. fatigans). Eight of the viruses (Itaporanga, Arumowot, Bujarn, Karimabad, Salehabad, Pacui, Chilibre and BeAn 100049) multiplied in one or both mosquito species when these were maintained at 32 deg C for 10 days. Icoaraci virus was detected in mosquitos after the 10-day incubation period but did not increase in titre. The remaining 13 agents tested did not survive following inoculation. The results of these experiments indicate that the mosquito-inoculation technique is less effective for the propagation of Phlebotomus fever group viruses than culture in Vero cells of newborn mice. Attempts to demonstrate transovarial transmission of Itaporanga and Arumowot viruses by infected females of A. albopictus and C. p. fatigans were unsuccessful, no virus being detected in the F1 adults.
KW  - mosquito nets
KW  - persistence
KW  - replication
KW  - Aedes albopictus
KW  - Chilibre virus
KW  - CULEX QUINQUEFASCIATUS
KW  - Culicidae
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Culex
KW  - Phlebovirus
KW  - Bunyaviridae
KW  - negative-sense ssRNA Viruses
KW  - ssRNA Viruses
KW  - RNA Viruses
KW  - viruses
KW  - Culex pipiens
KW  - Arumowot virus
KW  - Asian tiger mosquito
KW  - BeAn 100049 virus
KW  - Bujarn virus
KW  - Culex pipiens fatigans
KW  - Icoaraci virus
KW  - Itaporanga virus
KW  - Karimabad virus
KW  - mosquitoes
KW  - Pacui virus
KW  - Phlebotomus fever viruses
KW  - Salehabad virus
KW  - Other Control Measures (HH700) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Records of phoretic attachment of Mallophaga (Insecta: Phthiraptera) on insects other than Hippoboscidae.
AU  - Keirans, J. E.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1975///
VL  - 12
IS  - 4
SP  - 476
EP  - 476
SN  - 0022-2585
AD  - Keirans, J. E.: US Department of Health, Education, and Welfare, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19760531465.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A few records of the occurrence of Mallophaga on Siphonaptera, Diptera (including mosquitos), Odonata, Hymenoptera and Lepidoptera are presented. Nearly all records are of Mallophaga that are normally ectoparasites of mammals.
KW  - Culicidae
KW  - Diptera
KW  - Hymenoptera
KW  - Lepidoptera
KW  - Mallophaga
KW  - Odonata
KW  - Siphonaptera
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Phthiraptera
KW  - mosquitoes
KW  - Siponaptera
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of spotted fever group and Wolbachia-like agents from field-collected materials by means of plaque formation in mammalian and mosquito cells.
AU  - Cory, J.
AU  - Yunker, C. E.
AU  - Howarth, J. A.
AU  - Hokama, Y.
AU  - Hughes, L. E.
AU  - Thomas, L. A.
AU  - Clifford, C. M.
JO  - Acta Virologica
JF  - Acta Virologica
Y1  - 1975///
VL  - 19
IS  - 5
SP  - 443
EP  - 445
SN  - 0001-723X
AD  - Cory, J.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19760537456.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Three isolations in California from Dermacentor occidentalis Marx of a rickettsia of the spotted fever group and 5 isolations from chipmunks (Eutamias ruficaudus) of a Wolbachia-like agent were obtained from plaques formed in Singh's cultures of cells of Aedes albopictus (Skuse) and Vero cell cultures. These organisms could not be isolated by injection of the infected ticks or blood into embryonated chicken eggs, guineapigs or voles (Microtus pennsylvanicus), but fluid cultures of Grace's cultures of cells of Antheraea eucalypti Scott and Singh's cultures of cells of Aedes albopictus inoculated with the blood yielded the Wolbachia-like agent.
KW  - cell lines
KW  - introduced species
KW  - isolation
KW  - mosquito nets
KW  - California
KW  - USA
KW  - Acari
KW  - Aedes albopictus
KW  - Culicidae
KW  - Dermacentor occidentalis
KW  - Diptera
KW  - Rickettsiales
KW  - Wolbachia
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - Dermacentor
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Anaplasmataceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Antheraea
KW  - Saturniidae
KW  - Lepidoptera
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Antheraea eucalypti
KW  - Asian tiger mosquito
KW  - bacterium
KW  - Caligula
KW  - Eutamias ruficaudus
KW  - exotic organisms
KW  - exotic species
KW  - introduced organisms
KW  - mosquitoes
KW  - naturalized species
KW  - non-indigenous organisms
KW  - non-indigenous species
KW  - non-native organisms
KW  - non-native species
KW  - nonindigenous organisms
KW  - nonindigenous species
KW  - occidentalis, Dermacentor
KW  - Opodiphthera
KW  - Opodiphthera eucalypti
KW  - Opodipthera eucalypti
KW  - spotted-fever rickettsiae
KW  - United States of America
KW  - Wolbachia-like organism
KW  - Wolbachia-like organisms
KW  - Other Control Measures (HH700) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rocky Mountain spotted fever (tick-borne typhus) in South Carolina: an educational program and tick/rickettsial survey in 1973 and 1974.
AU  - Burgdorfer, W.
AU  - Adkins, T. R., Jr.
AU  - Priester, L. E.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1975///
VL  - 24
IS  - 5
SP  - 866
EP  - 872
SN  - 0002-9637
AD  - Burgdorfer, W.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19750530471.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Because the incidence of spotted fever is increasing in South Carolina, campaigns were carried out in 1973 and 1974 to provide the public and medical practitioners, through pamphlets and news media, with information about spotted fever and the ticks that transmit the causative agent (Rickettsia rickettsi). People were also invited to save and submit live ticks removed from vegetation, animals and man for examination by the haemolymph test. A total of 1186 ticks comprising 987 examples of Dermacentor variabilis (Say), 103 of Rhipicephalus sanguineus (Latr.), and 96 of Amblyomma americanum (L.) were examined. Rickettsiae identified by direct immunofluorescence as members of the spotted fever group were detected in 49 (4.9%) of the examples of D. variabilis, and 16 (16.6%) of those of A. americanum. Two hundred and twenty of the ticks (199 of D. variabilis, 17 of A. americanum and 4 of H. sanguineus) were recorded as having been attached to 199 persons. Nine of these ticks (8 of D. variabilis and 1 of A. americanum) were positive by the haemolymph test for rickettsiae of the spotted fever group. Infected ticks were collected from each of the three major South Carolina biogeographical regions: piedmont, sandhill and coastal plain. Since education is the first and most important step in preventing spotted fever, educational programmes and tick examination services similar to those described are suggested for other states that have a high incidence of spotted fever.
KW  - detection
KW  - IMMUNOFLUORESCENCE
KW  - Rocky Mountain spotted fever
KW  - South Carolina
KW  - USA
KW  - Acari
KW  - Amblyomma americanum
KW  - Dermacentor variabilis
KW  - man
KW  - Metastigmata
KW  - Rhipicephalus sanguineus
KW  - Rickettsia rickettsii
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Amblyomma
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Dermacentor
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Rhipicephalus
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southeastern States of USA
KW  - bacterium
KW  - fluorescent antibody technique
KW  - IFAT
KW  - lone star tick
KW  - Rickettsia rickettsi
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Laboratory studies of transovarial transmission of La Crosse and other arboviruses by Aedes albopictus and Culex fatigans.
AU  - Tesh, R. B.
AU  - Gubler, D. J.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1975///
VL  - 24
IS  - 5
SP  - 876
EP  - 880
SN  - 0002-9637
AD  - Tesh, R. B.: Pacific Research Station, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19750530472.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - La Crosse virus was transovarially transmitted by experimentally infected females of Aedes albopictus (Skuse), which is not a natural vector of the virus, to 2.7% of their offspring in the F1 generation. Progeny of both sexes were infected. Mean virus titres were 104.6 plaque forming units/insect in parent mosquitos and 103.4 in infected F1 generation adults. The infected offspring were randomly distributed among the female parents. After two serial passages in A. albopictus, a marked change occurred in the plaque morphology of the virus but this had no apparent effect on the subsequent vertical transmission rate. In contrast, transovarial transmission did not occur in Culex pipiens fatigans Wied. (C. fatigans) infected with La Crosse virus or in A. albopictus or C. p. fatigans infected with vesicular stomatitis-Indiana, Cache Valley, Batai, Arumowot, and Itaporanga viruses.
KW  - mosquito nets
KW  - transovarial transmission
KW  - vesicular stomatitis viruses
KW  - Aedes albopictus
KW  - Batai virus
KW  - Cache Valley virus
KW  - Culex pipiens
KW  - CULEX QUINQUEFASCIATUS
KW  - Culicidae
KW  - Diptera
KW  - La Crosse virus
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Bunyamwera virus
KW  - Orthobunyavirus
KW  - Bunyaviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Culex
KW  - California encephalitis virus
KW  - Vesiculovirus
KW  - Rhabdoviridae
KW  - Mononegavirales
KW  - Culex pipiens
KW  - Arumowot virus
KW  - Asian tiger mosquito
KW  - Culex pipiens fatigans
KW  - Itaporanga virus
KW  - mosquitoes
KW  - not transmitted transovarially
KW  - vesicular stomatitis virus
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A potential antileukemic substance present in Globularia alypum.
AU  - Caldes, G.
AU  - Prescott, B.
AU  - King, J. R.
JO  - Planta Medica
JF  - Planta Medica
Y1  - 1975///
VL  - 27
IS  - 1
SP  - 72
EP  - 76
SN  - 0032-0943
AD  - Caldes, G.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19750328888.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Horticultural Science
N2  - In a survey of medicinal plants from Greece antileukemic extracts of G. alypum were shown to contain high concentrations of carbohydrates, sugar alcohols and phenolic compounds.
KW  - medicinal plants
KW  - medicinal properties
KW  - Globularia alypum
KW  - Globularia
KW  - Globulariaceae
KW  - Scrophulariales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Science (General) (FF000) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750328888&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plaque production by arboviruses in Singh's Aedes albopictus cells.
AU  - Yunker, C. E.
AU  - Cory, J.
JO  - Applied Microbiology
JF  - Applied Microbiology
Y1  - 1975///
VL  - 29
IS  - 1
SP  - 81
EP  - 89
AD  - Yunker, C. E.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19750526821.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Plaquing tests are reported of 124 virus strains, mostly arboviruses of 21 serological groups, in Singh's line of cells of Aedes albopictus (Skuse). The 30 of these that plaqued were arboviruses of six groups and were known or presumed to be mosquito-borne. Those failing to plaque were 86 strains of arboviruses, mostly tick-borne, 2 strains of insect pathogens and 6 animal viruses not classified as arboviruses. Among mosquito-borne agents, plaquing ability appeared to be related to serological classification. Viruses of the California group and most of those of group A failed to plaque but nearly all members of the B and Bunyamwera groups readily plaqued. Within group B, 14 of 16 mosquito-borne agents plaqued, but none of 13 tick-borne viruses or viruses that arthropods are not known to transmit did so. Some implications of these results for the recognition and classification of arboviruses are discussed.
KW  - arboviruses
KW  - cell lines
KW  - mosquito nets
KW  - Aedes albopictus
KW  - Bunyamwera virus
KW  - Culicidae
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Orthobunyavirus
KW  - Bunyaviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - Asian tiger mosquito
KW  - California viruses
KW  - mosquitoes
KW  - not producing plaques
KW  - plaque production
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Uses of the ring-tab of cans in the entomology laboratory.
AU  - Burton, G. J.
JO  - Mosquito News
JF  - Mosquito News
Y1  - 1975///
VL  - 35
IS  - 3
SP  - 411
EP  - 412
AD  - Burton, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19750530662.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Medical & Veterinary Entomology
KW  - apparatus
KW  - mosquito nets
KW  - Culicidae
KW  - Diptera
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - made from ring-tab of cans
KW  - mosquitoes
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of beta -(2-furoyl)-L-alanine from the hydrolyzed extracts of Koelreuteria paniculata (golden rain tree) seeds.
AU  - Irreverre, F.
AU  - Wilson, E.
AU  - Fales, H. M.
AU  - Sun, T.
AU  - Sokoloski, E.
JO  - Lloydia
JF  - Lloydia
Y1  - 1975///
VL  - 38
IS  - 2
SP  - 178
EP  - 180
AD  - Irreverre, F.: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19750331473.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Horticultural Science
N2  - The structure and properties of this amino acid are described.
KW  - amino acids
KW  - composition
KW  - medicinal plants
KW  - medicinal properties
KW  - ornamental plants
KW  - ornamental woody plants
KW  - seeds
KW  - woody plants
KW  - Koelreuteria paniculata
KW  - plants
KW  - Koelreuteria
KW  - Sapindaceae
KW  - Sapindales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - drug plants
KW  - Koelreuteria paniculata B-(2-furoyl)-1-alanine
KW  - medicinal herbs
KW  - officinal plants
KW  - ornamentals
KW  - Plant Composition (FF040) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pesticide toxicity and potential for cancer: a proper perspective.
AU  - Kraybill, H. F.
JO  - Pest Control
JF  - Pest Control
Y1  - 1975///
VL  - 43
IS  - 12
SP  - 10
EP  - 16
SN  - 0031-6121
AD  - Kraybill, H. F.: National Cancer Institute, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19760532652.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 50-29-3.  Subject Subsets: Agricultural Entomology
N2  - In this review of studies on the possible relation between chemical pesticides and cancer, and of the means by which this may be assessed, the author discusses the significance of toxicity and the principles employed in the calculation of risk (body retention and burden of the pesticide, the possibility of a threshold, the degree of added risk, the safety margin for susceptible members of the population, the time required for tumour formation, metabolic overloading, and epidemiological verification of experimental studies). No chemicals used as pesticides have so far been conclusively proved carcinogenic to man, or to more than two species of other animals. A distinction is made between carcinogens and cocarcinogens, which operate synergistically to produce cancer in an organism already exposed to cancer risk from environmental factors or from some individual physiological weakness or injury. The possibility that DDT may be a cocarcinogen is discussed.
KW  - agricultural entomology
KW  - carcinogens
KW  - DDT
KW  - neoplasms
KW  - nontarget effects
KW  - pesticides
KW  - toxicity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cocarcinogenicity
KW  - cocarcinogens
KW  - dicophane
KW  - relation of chemical pesticides
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Organisms mimicking Pneumocystis carinii.
AU  - Young, R. C.
AU  - Bennett, J. E.
AU  - Chu, E. W.
T2  - Lancet
JO  - Lancet
JF  - Lancet
Y1  - 1976///
VL  - 2
IS  - 7994
SP  - 1082
EP  - 1083
AD  - Young, R. C.: Medicine Branch, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19772503985.  Publication Type: Correspondence.  Language: English.  Subject Subsets: Protozoology; Medical & Veterinary Mycology
N2  - Pitfalls in the diagnosis of Pneumocystis carinii are briefly discussed. The case of a patient with preleucaemia and peripheral pancytopenia is described. Organisms were seen in material obtained from bronchial brushing which seemed typical of Pneumocystis when stained with Gomovi/methamine-silver. Fungal cultures of sputum obtained after bronchoscopy grew the yeast Torulopsis glabrata. It is considered that the organism in the bronchial brushing material was probably T. glabrata and not Pneumocystis. It is thought that, normally, budding should distinguish the 2 organisms.
KW  - diagnosis
KW  - differential diagnosis
KW  - parasites
KW  - Candida
KW  - Candida glabrata
KW  - Cryptococcus (Fungi)
KW  - Histoplasma
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - invertebrates
KW  - Torulopsis
KW  - Candida
KW  - Cryptococcus (Deuteromycotina)
KW  - fungus
KW  - Hyphomycetes
KW  - mimicking Pneumocystis carinii
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19772503985&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Animal disease agents transmitted by horse flies and deer flies (Diptera: Tabanidae).
AU  - Krinsky, W. L.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1976///
VL  - 13
IS  - 3
SP  - 225
EP  - 275
SN  - 0022-2585
AD  - Krinsky, W. L.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19770542791.  Publication Type: Journal Article.  Language: English.  Number of References: 7 pp. ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science; Protozoology
N2  - Published reports of tabanid transmission of pathogenic agents of animals (including man) are reviewed. Experimental evidence is discussed for tabanid transmission of viruses, bacteria, Protozoa and helminths. The results of laboratory and field tests indicate that tabanids are essential to the biological transmission of the Protozoa Haemoproteus metchnikovi and Trypanosoma theileri and of the helminths Loa loa, Dirofilaria roemeri and Elaeophora schneideri, and that tabanids are mechanical vectors of the viruses of equine infections anaemia, vesicular stomatitis, hog cholera and rinderpest, the bacteria Anaplasma marginale, Bacillus anthracis, Clostridium chauvoei, Pasteurella multocida, P. tularensis (Francisella tularensis), Brucella spp., Listeria monocytogenes and Erysipelothrix rhusiopathae, the Protozoa Besnoitia besnoiti, T. evansi, T. equiperdum, T. congolense, T. brucei brucei and T. rhodesiense. The extent of the importance of tabanids in the natural mechanical transmission of most of these agents is not known. Indirect modes of transmission, involving secondary blood-feeding insects at the sites of tabanid bites or contamination by means of agents adhering to external tabanid structures are briefly discussed.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The transmission by tabanids of pathogens to man and animals is comprehensively reviewed, with special emphasis on the experimental evidence. Viruses, bacteria, protozoa and helminths are dealt with separately. The species of Tabanidae recorded as hosts of specific organisms are tabulated. Laboratory and field studies indicate that tabanids are essential for the development and transmission of Haemoproteus metchnikovi and Trypanosoma theileri and that they act as mechanical vectors of Besnoitia besnoiti, T. evansi, T. equiperdum, T. congolense, T. brucei brucei and T.b. gambiense (rhodesiense). Each of these species is discussed, as well as Anaplasma marginale and Leptospira spp.
KW  - disease transmission
KW  - disease vectors
KW  - Epidemiology
KW  - equine infectious anaemia
KW  - Helminths
KW  - insect pests
KW  - parasites
KW  - reviews
KW  - rinderpest
KW  - swine fever
KW  - transmission
KW  - vesicular stomatitis viruses
KW  - Anaplasma marginale
KW  - Apicomplexa
KW  - Bacillus anthracis
KW  - Bacteria
KW  - Besnoitia besnoiti
KW  - Brucella
KW  - Classical swine fever virus
KW  - Clostridium chauvoei
KW  - Diptera
KW  - Elaeophora schneideri
KW  - FRANCISELLA TULARENSIS
KW  - insects
KW  - Listeria monocytogenes
KW  - Loa loa
KW  - Nematoda
KW  - Pasteurella multocida
KW  - Pelecitus
KW  - Pelecitus roemeri
KW  - Protozoa
KW  - SARCOMASTIGOPHORA
KW  - Tabanidae
KW  - Trypanosoma brucei
KW  - Trypanosoma congolense
KW  - Trypanosoma equiperdum
KW  - Trypanosoma evansi
KW  - Trypanosoma rhodesiense
KW  - Trypanosoma theileri
KW  - viruses
KW  - Anaplasma
KW  - Anaplasmataceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Bacillus (Bacteria)
KW  - Bacillaceae
KW  - Bacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Besnoitia
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Brucellaceae
KW  - Rhizobiales
KW  - Pestivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - Elaeophora
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Francisella
KW  - Francisellaceae
KW  - Thiotrichales
KW  - Gammaproteobacteria
KW  - Listeria
KW  - Listeriaceae
KW  - Loa
KW  - Pasteurella
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Diptera
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Haemoproteus
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Pelecitus
KW  - Vesiculovirus
KW  - Rhabdoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - African eyeworm
KW  - bacterium
KW  - cattle plague
KW  - Dirofilaria roemeri
KW  - equine infectious anemia
KW  - Erysipelothrix rhusiopathae
KW  - Haemoproteus metchnikovi
KW  - hog cholera
KW  - Mastigophora
KW  - nematodes
KW  - parasitic worms
KW  - Pasteurella tularensis
KW  - pest insects
KW  - Secernentea
KW  - Simondia
KW  - Simondia metchnikovi
KW  - Spirurida
KW  - Swine fever virus
KW  - Tabanid transmission of animal disease agents
KW  - Trypansoma equiperdum
KW  - vectors of animal disease agents
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of different strains of Plasmodium vivax in two species of Anopheles.
AU  - Collins, W. E.
AU  - Contacos, P. G.
AU  - Richardson, B. B.
AU  - Skinner, J. C.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1976///
VL  - 25
IS  - 3
SP  - 372
EP  - 375
SN  - 0002-9637
AD  - Collins, W. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19760537126.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Females of Anopheles freeborni Aitken were fed on monkeys (Aotus trivirgatus) or men infected with various strains of Plasmodium vivax. Of those females that had oocysts on the gut wall, a higher proportion of those infected with New World strains of P. vivax had infections in the salivary glands than those infected with Asian, particularly South Vietnamese, strains. Females of A. maculatus Theo. supported development of all strains of P. vivax from oocysts to heavily infected salivary glands. The results suggest that strains of P. vivax that were introduced into the United States from Vietnam would be less likely to be transmitted by the native species A. freeborni than would malaria from some other areas.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Anopheles freeborni with oocyst infections had salivary gland infections at a higher rate with strains of Plasmodium vivax from the New World than with strains from Asia, particularly those from South Viet Nam. A. maculatus supported development from oocysts to heavily infected salivary glands for all the strains of P. vivax tested. The results suggest that P. vivax introduced into the USA from Viet Nam would be less likely to be transmitted by native A. freeborni mosquitoes than would malaria from some other areas. [AS].
KW  - development
KW  - insect pests
KW  - life history
KW  - mosquito nets
KW  - parasites
KW  - strains
KW  - Anopheles freeborni
KW  - Anopheles maculatus
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Plasmodium vivax
KW  - protozoa
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - mosquitoes
KW  - pest insects
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760537126&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A field trial of competitive displacement of Aedes polynesiensis by Aedes albopictus on a Pacific atoll.
AU  - Rosen, L.
AU  - Rozeboom, L. E.
AU  - Reeves, W. C.
AU  - Saugrain, J.
AU  - Gubler, D. J.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1976///
VL  - 25
IS  - 6
SP  - 906
EP  - 913
SN  - 0002-9637
AD  - Rosen, L.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, PO Box 1680, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19770540098.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Helminthology
N2  - Earlier laboratory studies and field observations had suggested that it might be possible to reduce the size of populations of, or to eliminate, Aedes polynesiensis Marks by the introduction of A. albopictus (Skuse). The former species is the principal vector of non-periodic filariasis caused by Wuchereria bancrofti and the latter is a closely related species refractory to infection with human filariae. The practicability of such competitive displacement was studied in a field test on a remote coral atoll, Taiaro, in the Pacific Ocean, where there was an established population of A. polynesiensis. Three strains of A. albopictus were liberated at separate localities on the atoll, which is approximately circular and about 5 km in diameter. The fate of the released species was followed for 4 years. One strain disappeared within 12 months of release and the other two disappeared within 48 months. It was not clear whether establishment failed to occur because the strains were unsuitable, the general environment was inappropriate or A. polynesiensis was present in such numbers that A. albopictus rarely succeeded in mating with its own species.
KW  - biological control
KW  - control
KW  - disease transmission
KW  - disease vectors
KW  - filariids
KW  - helminths
KW  - insect control
KW  - mosquito nets
KW  - natural enemies
KW  - parasites
KW  - transmission
KW  - French Polynesia
KW  - Aedes albopictus
KW  - Aedes polynesiensis
KW  - Culicidae
KW  - Diptera
KW  - Insects
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - France overseas
KW  - Polynesia
KW  - Oceania
KW  - Pacific Islands
KW  - Asian tiger mosquito
KW  - biocontrol
KW  - competition
KW  - competitive displacement
KW  - displacement by non-vector
KW  - human filariae
KW  - mosquitoes
KW  - nematodes
KW  - not infective
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Taiaro
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Biological Control (HH100) 
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Behaviour (LL300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serological studies on the epidemiology of sandfly fever in the Old World.
AU  - Tesh, R. B.
AU  - Saidi, S.
AU  - Gajdamovic, S. Ja.
AU  - Rodhain, F.
AU  - Vesenjak-Hirjan, J.
JO  - Bulletin of the World Health Organization
JF  - Bulletin of the World Health Organization
Y1  - 1976///
VL  - 54
IS  - 6
SP  - 663
EP  - 674
SN  - 0042-9686
AD  - Tesh, R. B.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institutes of Health, PO Box 1680, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19770547071.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Number of References: 33 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Selected human sera from 59 different localities in Africa, the Mediterranean littoral, eastern Europe and Asia were examined by plaque reduction neutralisation test against 8 sandfly fever serotypes (Sicilian, Naples, Arumowot, Sudan 754-61, Karimabad, Salehabad, Gordil and Saint Floris) known to occur in the Old World. Results of these studies provide new information on the geographical distribution and prevalence of human infection with each of the viruses. Specific neutralising antibodies were detected against all of the agents except Salehabad. Antibodies to Naples and Sicilian serotypes were encountered most frequently and had the widest geographical range; moreover, they were found only in areas where Phlebotomus papatasi (Scop.) occurs. Age-specific antibody rates for several of the viruses are presented. These data and the epidemiology of sandfly fever are discussed.
KW  - antibodies
KW  - disease transmission
KW  - transmission
KW  - Diptera
KW  - man
KW  - Phlebotominae
KW  - Phlebotomus papatasi
KW  - Psychodidae
KW  - Sandfly fever Naples virus
KW  - viruses
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - Phlebovirus
KW  - Bunyaviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Old World
KW  - sandfly fever viruses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An in vitro assay for T cell immunity to malaria in mice.
AU  - Weinbaum, F. I.
AU  - Evans, C. B.
AU  - Tigelaar, R. E.
JO  - Journal of Immunology
JF  - Journal of Immunology
Y1  - 1976///
VL  - 116
IS  - 5
SP  - 1280
EP  - 1283
AD  - Weinbaum, F. I.: Lab. of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19762500813.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Protozoology
N2  - After infection with a nonlethal strain of murine malaria (17 XNL Plasmodium berghei yoelii), BALB/c mice are then resistant to a lethal strain (17XL P. b. yoelii). BALB/c mice were infected with 17 XNL, and challenged 3 weeks later, after clearing their parasitaemias, with 17XL. 3 weeks thereafter, spleen cells from such immune animals were used to define an early-peaking T-dependent (anti-thymus sensitive) antigen-specific proliferative response when incubated in vitro with 17XL-infected red blood cells, or a saline-soluble 17XL antigen preparation. T-dependent responsiveness of spleen cells from uninoculated controls to the 17XL antigen preparation was also observed, but demonstrated a much different (delayed) kinetics from that observed with immune cells. [AS]
KW  - immunology
KW  - parasites
KW  - MICE
KW  - Plasmodium berghei
KW  - protozoa
KW  - Rodents
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - T cell immunity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Atypical radiographic features in Pneumocystis carinii pneumonia.
AU  - Doppman, J. L.
JO  - National Cancer Institute Monograph
JF  - National Cancer Institute Monograph
Y1  - 1976///
IS  - 43
SP  - 89
EP  - 95
AD  - Doppman, J. L.: National Institutes of Health, Public Health Service, Dep. of Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1  - Accession Number: 19780848061.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Protozoology
N2  - In 30 patients with confirmed Pneumocystis pneumonia the typical radiographic picture was one of acute bilateral perihilar and basilar infiltrate progressing to diffuse alveolar consolidation within 3 to 5 days, unassociated with adenopathy or pleural changes. In some patients however various atypical findings were present on some occasions.
KW  - diagnosis
KW  - parasites
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - diagnosis by X-rays
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The epidemiology of the relapsing fevers.
AU  - Burgdorfer, W.
T2  - R.C.Johnson (Editor). The biology of parasitic spirochetes.
JO  - R.C.Johnson (Editor). The biology of parasitic spirochetes.
JF  - R.C.Johnson (Editor). The biology of parasitic spirochetes.
Y1  - 1976///
SP  - 191
EP  - 200
CY  - New York; USA
PB  - Academic Press, Inc.
AD  - Burgdorfer, W.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, USA.
N1  - Accession Number: 19770545646.  Publication Type: Miscellaneous.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - An outline is presented of the epidemiological characteristics of louse-borne (epidemic) relapsing fever, caused by Borrelia recurrentis, which is transmitted by Pediculus humanus humanus L. and of tick-borne (endemic) relapsing fevers caused by spirochaetes transmitted by Ornithodoros spp. The current world distribution and status of these diseases is reviewed and discussed, and information on vectors, aetiological agents, animal hosts and distribution is summarised in a table.
KW  - disease transmission
KW  - epidemiology
KW  - relapsing fever
KW  - transmission
KW  - Acari
KW  - Anoplura
KW  - Borrelia recurrentis
KW  - Ornithodoros
KW  - Pediculus humanus
KW  - Spirochaetales
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Phthiraptera
KW  - insects
KW  - Hexapoda
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Argasidae
KW  - Metastigmata
KW  - Acari
KW  - Pediculus
KW  - Pediculidae
KW  - Anoplura
KW  - Pediculus humanus
KW  - bacterium
KW  - body louse
KW  - Pediculus humanus humanus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A simple technique for the detection of dengue antigen in mosquitoes by immunofluorescence.
AU  - Kuberski, T. T.
AU  - Rosen, L.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1977///
VL  - 26
IS  - 3
SP  - 533
EP  - 537
SN  - 0002-9637
AD  - Kuberski, T. T.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institutes of Health, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19770547170.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Dengue antigen was demonstrated by a direct fluorescent antibody technique in simple head squashes of both males and females of Aedes albopictus (Skuse) infected with any of the 4 dengue serotypes. Dengue viruses can be isolated rapidly and simply by combining this technique with that of parenteral inoculation of mosquitoes with test material.
KW  - detection
KW  - IMMUNOFLUORESCENCE
KW  - mosquito nets
KW  - Aedes albopictus
KW  - Culicidae
KW  - dengue virus
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Asian tiger mosquito
KW  - fluorescent antibody technique
KW  - IFAT
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of dengue viruses using complement fixing antigen produced in mosquitoes.
AU  - Kuberski, T. T.
AU  - Rosen, L.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1977///
VL  - 26
IS  - 3
SP  - 538
EP  - 543
SN  - 0002-9637
AD  - Kuberski, T. T.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institutes of Health, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19770547171.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Complement fixing antigen produced in males of Aedes albopictus (Skuse) infected with dengue viruses was used in conjunction with prototype immune mouse ascitic fluids to identify these viruses as to serotype.
KW  - complement fixation tests
KW  - detection
KW  - mosquito nets
KW  - Aedes albopictus
KW  - Culicidae
KW  - dengue virus
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Asian tiger mosquito
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Control of antennal hair erection in male mosquitoes.
AU  - Nijhout, H. F.
JO  - Biological Bulletin
JF  - Biological Bulletin
Y1  - 1977///
VL  - 153
IS  - 3
SP  - 591
EP  - 603
SN  - 0006-3185
AD  - Nijhout, H. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19780551124.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The long fibrillae, or hairs, on the antennae of male mosquitoes play an essential role in the detection of female flight sound, the sole sexual attractant. In Anopheles stephensi List., as in many other genera and species, these long hairs are recumbent on the shaft of the antenna during the daytime and become briefly erect at dusk, at the time when swarming and mating activity occurs. Evidence is presented from studies in the USA that the erection of the antennal hairs is under direct nervous control. Isolated antennae can be induced to erect their hairs only in the presence of alpha -adrenergic agonists and this response is blocked in the presence of the alpha -adrenergic blocking drug phentolamine. Thus, a cell surface receptor, resembling the vertebrate alpha -adrenergic receptor probably mediates the response to the natural neurotransmitter. The action of alpha -adrenergic drugs is mimicked by cyclic nucleotides and also by theophylline.
KW  - antennae
KW  - mosquito nets
KW  - Anopheles stephensi
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - blocking erection of antennal hairs
KW  - mosquitoes
KW  - nervous control of erection of hairs
KW  - phentolamine
KW  - Other Control Measures (HH700) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780551124&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - A critique of merozoite and sporozoite vaccines in malaria.
AU  - Miller, L. H.
A2  - Miller, L.H.
A2  - Pino, J.A.
A2  - McKelvey, J.J., Jr.
T2  - Immunity to blood parasites of animals and man. (Advances in experimental medicine and biology, Volume 93).
JO  - Immunity to blood parasites of animals and man. (Advances in experimental medicine and biology, Volume 93).
JF  - Immunity to blood parasites of animals and man. (Advances in experimental medicine and biology, Volume 93).
Y1  - 1977///
SP  - 113
EP  - 120
CY  - New York, USA & London; UK
PB  - Plenum Press.
AD  - Miller, L. H.: Lab. of Parasit. Dis., National Inst. of Allergy & Infectious Dis., National Institutes of Health, Bethesda, MD 20014, USA.
N1  - Accession Number: 19780847790.  Publication Type: Miscellaneous.  Language: English.  Subject Subsets: Protozoology
N2  - The relative merits of sporozoite and merozoite vaccines against malaria are discussed. Merozoite vaccine has been studied only for a short while, only in relation to Plasmodium knowlesi in monkeys, and challenge has been by blood forms only. Sporozoite vaccine has been successful after sporozoite challenge in avian, rodent, monkey and human malaria. The development of a merozoite vaccine seems the more attainable goal but this should not deter research on sporozoite immunity and other approaches.
KW  - immunology
KW  - parasites
KW  - monkeys
KW  - Plasmodium
KW  - Plasmodium knowlesi
KW  - Primates
KW  - protozoa
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Plasmodium
KW  - Haemosporida
KW  - immunization with merozoites
KW  - immunization with sporozoites immunology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical differences between serotypes of Cryptococcus neoformans.
AU  - Bennett, J. E.
AU  - Kwon-Chung, K. J.
AU  - Theodore, T. S.
JO  - Sabouraudia
JF  - Sabouraudia
Y1  - 1978///
VL  - 16
IS  - 3
SP  - 167
EP  - 174
AD  - Bennett, J. E.: Nat. Inst. Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20014, USA.
N1  - Accession Number: 19781348932.  Publication Type: Journal Article.  Language: English.  Language of Summary: Spanish.  Number of References: 15 ref. Registry Number: 60-72-5, 110-17-8, 6915-15-7, 110-15-6.  Subject Subsets: Medical & Veterinary Mycology; Veterinary Science
N2  - Uptake of radiolabelled l-malic acid was approximately tenfold greater in serotype B and C than in A and D isolates. Assimilation of l-malic, fumaric and succinic acids also distinguished serotypes B and C from A and D. Greening of Guizotia seed agar occurred with 18 of 32 serotype B and C but in none of 91 serotype A or D isolates. The one property not following the same line of division was relatively slow creatinine assimilation, which distinguished type A alone.
KW  - biochemistry
KW  - Creatinine
KW  - Fumaric acid
KW  - Malic acid
KW  - poultry
KW  - poultry diseases
KW  - Succinic acid
KW  - Cryptococcus (Fungi)
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - assimilation of Krebs cycle intermediates
KW  - Cryptococcus (Deuteromycotina)
KW  - differences between serotypes
KW  - domesticated birds
KW  - fungus
KW  - malate
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diuresis after a bloodmeal in female Anopheles freeborni.
AU  - Nijhout, H. F.
AU  - Carrow, G. M.
JO  - Journal of Insect Physiology
JF  - Journal of Insect Physiology
Y1  - 1978///
VL  - 24
IS  - 4
SP  - 293
EP  - 298
SN  - 0022-1910
AD  - Nijhout, H. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19780556494.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Females of Anopheles freeborni Aitken discharged urine rapidly and copiously for a brief time after taking a meal of blood. This diuresis began immediately on cessation of feeding and continued for about 30 min at a constant rate. A decline in this rate followed, and diuresis was completed 50 min after feeding. This time-course of diuresis was independent of the size of the meal; diuresis after large meals occurred at a higher rate, not over a longer time, than diuresis after small meals. Heat-stable and saline-soluble substances that induce rapid excretion by isolated Malpighian tubules can be extracted from the head and thoracic nervous system, suggesting the presence of a neurosecretory diuretic hormone similar to that found in other blood-sucking insects. Decapitation or section of the ventral nerve cord abolished the rapid phase of diuresis after a blood-meal. Therefore, in analogy to the situation in Glossina, the head is required either as the source of a diuretic hormone or as link in the pathway that stimulates its release.
KW  - diuresis
KW  - mosquito nets
KW  - Anopheles freeborni
KW  - Culicidae
KW  - Diptera
KW  - Glossina
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Glossinidae
KW  - blood-feeding
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780556494&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clonal growth of Entamoeba histolytica and other species of Entamoeba in agar.
AU  - Gillin, F. D.
AU  - Diamond, L. S.
JO  - Journal of Protozoology
JF  - Journal of Protozoology
Y1  - 1978///
VL  - 25
IS  - 4
SP  - 539
EP  - 543
SN  - 0022-3921
AD  - Gillin, F. D.: National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19780859070.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Protozoology
N2  - This is the first description of a method for growing axenized Entamoeba histolytica as colonies from single cells in agar suspension. Factors affecting the efficiency of colony formation included unknown characteristics of the amoebal strain, age of cells used, and the type and concentration of agar employed. Colony formation was dependent upon filling deep vessels (culture tubes or tissue culture flasks) with agar, probably to maintain reduced oxygen tension, and upon solidifying the agar rapidly at 0 deg C. In a study with the drug metronidazole, the agar colony method was useful for quantifying cell viability. 11 of 12 E. histolytica strains tested, as well as one E. terrapinae, one E. barreti and 3 E. invadens strains formed colonies in agar suspension. E. histolytica-like amoebae (Laredo type) and E. moshkovskii formed only tiny colonies in agar. [AS]
KW  - parasites
KW  - Entamoeba
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - clonal culture
KW  - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780859070&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Membrane potential dependent binding of scorpion toxin to the action potential sodium ionophore. Studies with a 3-(4-hydroxy 3-[125I] iodophenyl) propionyl derivative.
AU  - Ray, R.
AU  - Catterall, W. A.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1978///
VL  - 31
SP  - 397
EP  - 407
SN  - 0022-3042
AD  - Ray, R.: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19790566964.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A polypeptide toxin purified 80-fold from the venom of the scorpion Leiurus quinquestriatus (Hemprich & Ehrenberg) enhanced activation of the action potential Na+ ionophore by the alkaloid neurotoxins veratridine, batrachotoxin and aconitine in electrically excitable neuroblastoma cells. Studies suggested that scorpion toxin binds specificially to a regulatory component (gate) of the Na+ ionophore, the conformation of which is dependent on membrane potential.
KW  - peptides
KW  - toxins
KW  - venoms
KW  - Arachnida
KW  - Leiurus quinquestriatus
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leiurus
KW  - Buthidae
KW  - Scorpiones
KW  - Arachnida
KW  - venom
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790566964&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba.
AU  - Diamond, L. S.
AU  - Harlow, D. R.
AU  - Cunnick, C. C.
JO  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF  - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1  - 1978///
VL  - 72
IS  - 4
SP  - 431
EP  - 432
SN  - 0035-9203
AD  - Diamond, L. S.: National Institutes of Health, Bethesda, MD, 20014, USA.
N1  - Accession Number: 19780849994.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Protozoology
N2  - The preparation of a new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba spp. is described. TYI-S-33 (Trypticase, yeast extract, iron-serum) consists of a nutrient broth (TYI), a vitamin-Tween 80 mixture, and bovine serum. The medium is sensitive to light and is used within 96 hours after preparation for growth assays and within 10 days for maintenance of stock cultures. Biosate, a peptone mixture consisting of 2 parts Trypticase:one part yeast extract (by weight) can be substituted for the peptone components of TYI-S-33. The medium is then designated BI-S-33. The 2 forms of the medium can be used interchangeably. A few E. histolytica strains grew poorly, if at all, in the presence of 10% serum; 15% serum was necessary to culture these strains. Compared with TP-S-1 the new medium requires smaller inocula to maintain the cultures, the resulting yields are greater, growth is more uniform, and in the case of E. histolytica, the generation time has been reduced approximately one third.
KW  - culture
KW  - parasites
KW  - Entamoeba
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transovarial transmission of Japanese encephalitis virus by mosquitoes.
AU  - Rosen, L.
AU  - Tesh, R. B.
AU  - Lien, J. C.
AU  - Cross, J. H.
JO  - Science, USA
JF  - Science, USA
Y1  - 1978///
VL  - 199
IS  - 4331
SP  - 909
EP  - 911
AD  - Rosen, L.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19780554691.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2  - Females of Aedes albopictus (Skuse) and A. togoi (Theo.) infected with Japanese encephalitis virus either by intrathoracic inoculation or by ingestion of a virus-sucrose-erythrocyte mixture transmitted the virus to a small percentage of their F1 progeny. Adult F1 females of A. albopictus thus infected transmitted the virus in turn to newly hatched chickens by feeding on them.
KW  - chicks
KW  - Disease transmission
KW  - Japanese encephalitis
KW  - mosquito nets
KW  - poultry
KW  - transovarial transmission
KW  - vectors
KW  - Zoonoses
KW  - Aedes
KW  - Aedes albopictus
KW  - Aedes togoi
KW  - Culicidae
KW  - Diptera
KW  - fowls
KW  - Japanese encephalitis virus
KW  - Man
KW  - viruses
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Aedes
KW  - Gallus gallus
KW  - Gallus
KW  - Phasianidae
KW  - Galliformes
KW  - birds
KW  - vertebrates
KW  - Chordata
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - Asian tiger mosquito
KW  - chickens
KW  - domesticated birds
KW  - mosquitoes
KW  - Ochlerotatus
KW  - Ochlerotatus togoi
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Other Control Measures (HH700) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Observations on the subgenus Argas (Ixodoidea: Argasidae: Argas). 16. Argas (A.) moreli, new species, and keys to Neotropical species of the subgenus.
AU  - Keirans, J. E.
AU  - Hoogstraal, H.
AU  - Clifford, C. M.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1979///
VL  - 15
IS  - 3
SP  - 246
EP  - 252
SN  - 0022-2585
AD  - Keirans, J. E.: USDHEW, PHS, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19790563593.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Argas moreli sp. n., is described from males, females, and nymphs from a house, and from unknown situations, in Junin and Arequipa Provinces, at 4150 and 2329 m in altitude, in Peru. Probable hosts are wild birds, domestic fowls and man. The peripheral integument of this distinctive species lacks the cells similar to those of A. persicus (Oken) seen in several other Neotropical species of the subgenus Argas, but regularly spaced, deep sutures bounding a broad peripheral area with a small setiferous pit form 'pseudo persicus-like cells'. This species may represent a phylogenetic gradient between Argas species lacking persicus-like cells (all faunal regions, including Neotropical) and those having these cells (Neotropical only). Ticks identified as A. persicus, but likely to represent A. moreli, have been reported to bite man in Arequipa and to cause a severe pruritus.
KW  - descriptions
KW  - dwellings
KW  - hosts
KW  - integument
KW  - new species
KW  - pruritus
KW  - Peru
KW  - Acari
KW  - Argas persicus
KW  - man
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Argas
KW  - Argasidae
KW  - Metastigmata
KW  - Acari
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Andean Group
KW  - APEC countries
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Argas moreli
KW  - fowl tick
KW  - itchiness
KW  - itching
KW  - moreli, Argas
KW  - pruritus caused
KW  - tegument
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fluorescent antibody studies on the development of dengue-2 virus in Aedes albopictus (Diptera: Culicidae).
AU  - Kuberski, T.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1979///
VL  - 16
IS  - 4
SP  - 343
EP  - 349
SN  - 0022-2585
AD  - Kuberski, T.: Pacific Research Station, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806, USA.
N1  - Accession Number: 19800569862.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - In the laboratory in Honolulu, Hawaii, females of Aedes albopictus (Skuse) were fed with a suspension of sucrose, human blood cells and dengue-2 virus; groups of these mosquitoes were collected on alternate days for 3 weeks and tested by the fluorescent-antibody technique with a view to demonstrating the development of dengue virus. Dengue virus antigen was found to be limited to the cells of the posterior mid-gut 2 days after the infective blood-meal, but the proventriculus, fat-body, nervous system, ovariole sheath and portions of the salivary glands displayed fluorescence 6 days after infection. From the sixth day onwards, dengue antigen was found disseminated in numerous tissues, but the amount of demonstrable antigen and the intensity of fluorescence was most marked in structures of the nervous system. Viral antigen was not consistently or uniformly demonstrated in the salivary glands, and the type of fluorescence was qualitatively different from that of other infected tissues. Dengue antigen was not demonstrated in the eggs or spermathecae.
KW  - detection
KW  - IMMUNOFLUORESCENCE
KW  - mosquito nets
KW  - Aedes albopictus
KW  - Culicidae
KW  - dengue virus
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Asian tiger mosquito
KW  - fluorescent antibody technique
KW  - IFAT
KW  - localisation
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800569862&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Screening system for Egyptian plants with potential anti-tumour activity.
AU  - El-Merzabani, M. M.
AU  - El-Aaser, A. A.
AU  - Attia, M. A.
AU  - El-Duweini, A. K.
AU  - Ghazal, A. M.
JO  - Planta Medica
JF  - Planta Medica
Y1  - 1979///
VL  - 36
IS  - 2
SP  - 150
EP  - 155
SN  - 0032-0943
AD  - El-Merzabani, M. M.: National Cancer Institute, Cairo, Egypt.
N1  - Accession Number: 19800381235.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Horticultural Science
N2  - Eight species representing 8 genera from 8 families were screened. Hedera helix, Prosopis juliflora and Catharanthus roseus showed cytotoxic effects.
KW  - medicinal plants
KW  - medicinal properties
KW  - surveys
KW  - Egypt
KW  - Catharanthus roseus
KW  - Hedera helix
KW  - Prosopis juliflora
KW  - Catharanthus
KW  - Apocynaceae
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Hedera
KW  - Araliaceae
KW  - Apiales
KW  - Prosopis
KW  - Mimosoideae
KW  - Fabaceae
KW  - Fabales
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - Araliales
KW  - drug plants
KW  - ivy
KW  - medicinal herbs
KW  - Misr
KW  - officinal plants
KW  - Plant Science (General) (FF000) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800381235&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Screening system for Egyptian plants with potential anti-tumour activity.
AU  - Merzabani, M. M. El-
AU  - Aaser, A. A. El-
AU  - Attia, M. A.
AU  - Duweini, A. K. El-
AU  - Ghazal, A. M.
JO  - Planta Medica
JF  - Planta Medica
Y1  - 1979///
VL  - 36
IS  - 2
SP  - 150
EP  - 155
SN  - 0032-0943
AD  - Merzabani, M. M. El-: National Cancer Institute, Cairo, Egypt.
N1  - Accession Number: 19802605105.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref.
N2  - Eight species representing 8 genera from 8 families were screened. Hedera helix, Prosopis juliflora and Catharanthus roseus showed cytotoxic effects.
KW  - arid zones
KW  - medicinal plants
KW  - surveys
KW  - Egypt
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - arid regions
KW  - drug plants
KW  - medicinal herbs
KW  - Misr
KW  - officinal plants
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Other Sciences (ZZ000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19802605105&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Entamoeba histolytica: genetic control of susceptibility in chicken eggs.
AU  - Jaoum, K. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1979///
VL  - 47
IS  - 1
SP  - 54
EP  - 64
SN  - 0014-4894
AD  - Jaoum, K. C.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19790143864.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Animal Breeding
N2  - Five strains of axenised Entamoeba histolytica were established in eggs from White Leghorn fowls of several strains. The eggs of outbred and inbred fowls differed in the proportion of embryos from which the E. histolytica strains were recovered, and there were variations in the number of trophozoites recovered from individual positive eggs. It was possible to find individual, single-mated hens that laid only uniformly susceptible or resistant eggs. Susceptibility and resistance to E. histolytica could be demonstrated in embryonated eggs derived from outbred heterogeneous and highly inbred fowls, but eggs from a genetically stable source were relatively constant in the distribution of susceptible and resistant embryos. The results obtained suggested that susceptibility is a dominant trait, and may be linked with resistance to subgroup A avian leucosis viruses.
KW  - disease resistance
KW  - embryos
KW  - genetic control
KW  - genotypes
KW  - Entamoeba histolytica
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - resistance to disease
KW  - resistance to Entamoeba histolytica
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: exflagellation stimulated by a mosquito factor.
AU  - Nijhout, M. M.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1979///
VL  - 48
IS  - 1
SP  - 75
EP  - 80
SN  - 0014-4894
AD  - Nijhout, M. M.: National Institutes of Health, Bethesda, Maryland 20014, USA.
N1  - Accession Number: 19790862222.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Protozoology; Veterinary Science
N2  - Midgut tissue from Aedes aegypti stimulated exflagellation of gametocytes of Plasmodium gallinaceum in the absence of bicarbonate, a factor necessary for in vitro exflagellation. Exflagellation was also stimulated when washed infected red cells in a buffered saline (pH 7.4) not containing bicarbonate were introduced into the midgut by enema. The exflagellation-stimulating activity was neither sex nor species specific. Preparations of a mosquito exflagellation factor (MEF) were obtained without tisse disruption by collecting the fluid excreted by Anopheles stephensi females while they were feeding on warm saline. MEF was dialyzable and stable to boiling and decarbonation. Thus, MEF is not bicarbonate. [AS]
KW  - Gametes
KW  - in vitro
KW  - parasites
KW  - physiology
KW  - Aedes
KW  - Culicidae
KW  - Plasmodium
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Plasmodium
KW  - exflagellation & mosquito extract
KW  - Haemosporida
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790862222&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The ultrastructural aspects of Giardia.
AU  - Sheffield, H. G.
A2  - : Jakubowski, W.
A2  - Hoff, J.C.
T2  - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA).
JO  - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA).
JF  - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA).
Y1  - 1979///
SP  - 9
EP  - 20
CY  - Cincinnati, Ohio; USA
PB  - US Environmental Protection Agency.
AD  - Sheffield, H. G.: National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19790863699.  Publication Type: Miscellaneous.  Language: English.  Subject Subsets: Protozoology
N2  - The morphology of the trophozoite and cyst of Giardia lamblia as determined by transmission and scanning electron microscopy is reviewed.
KW  - parasites
KW  - reviews
KW  - ultrastructure
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Giardia lamblia
KW  - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790863699&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Extensive myiasis from tumbu fly larvae in Ghana, West Africa.
AU  - Biggar, R. J.
AU  - Morrow, H.
AU  - Morrow, R. H.
JO  - Clinical Pediatrics
JF  - Clinical Pediatrics
Y1  - 1980///
VL  - 19
IS  - 3
SP  - 231
EP  - 232
SN  - 0009-9228
AD  - Biggar, R. J.: National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19800579125.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The infestation of a previously healthy 14-month-old girl with 94 larvae of Cordylobia anthropophaga (blanch. & Berenger-Feraud) is described. Treatment involved application of an occlusive ointment over the hole in each lesion and extrusion of the larva by gentle pressure.
KW  - control
KW  - myiasis
KW  - removal
KW  - Ghana
KW  - Cordylobia anthropophaga
KW  - Diptera
KW  - man
KW  - Cordylobia
KW  - Calliphoridae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800579125&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Physiological changes governing the onset of sexual receptivity in male mosquitoes.
AU  - Beach, R.
JO  - Journal of Insect Physiology
JF  - Journal of Insect Physiology
Y1  - 1980///
VL  - 26
IS  - 4
SP  - 245
EP  - 252
SN  - 0022-1910
AD  - Beach, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19800574803.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 5289-74-7.  Subject Subsets: Medical & Veterinary Entomology
N2  - The effectors that erect antennal hairs in males of Aedes aegypti (L.) and Anopheles freeborni Aitken are shown to be unresponsive to the neurotransmitter that triggers antennal hair erection until 12-24 h after emergence. The unresponsive period can be prolonged by transfusion of haemolymph from newly-emerged males, or by injection of 20-hydroxyecdysone. This suggests that the hormone persisting after the metamorphosis from pupa to adult affects the duration of the post-emergence delay in antennal hair erection and is indirectly responsible for timing the onset of sexual receptivity in male mosquitoes.
KW  - ecdysterone
KW  - mosquito nets
KW  - Aedes aegypti
KW  - Anopheles freeborni
KW  - Culicidae
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - delaying onset of male sexual receptivity
KW  - factors governing onset
KW  - mosquitoes
KW  - sexual receptivity
KW  - Other Control Measures (HH700) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ovarian control of blood meal retention in the mosquito Anopheles freeborni.
AU  - Rosenberg, R.
JO  - Journal of Insect Physiology
JF  - Journal of Insect Physiology
Y1  - 1980///
VL  - 26
IS  - 7
SP  - 477
EP  - 480
SN  - 0022-1910
AD  - Rosenberg, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19800577901.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 5289-74-7.  Subject Subsets: Medical & Veterinary Entomology
N2  - Females of Anopheles freeborni Aitken began to excrete the haem-containing residue of a blood-meal about the time their eggs matured, 40-45 h after feeding. Ovariectomised females began to defaecate 15 h prematurely, while ovariectomised females treated with 20-hydroxyecdysone retained blood-meals longer, proportional to dose, than did untreated females. It is concluded that the production of ecdysteroids by the ovary initiates a mechanism for retention of the blood-meal in the mosquito.
KW  - blood-meals
KW  - ecdysterone
KW  - mosquito nets
KW  - Anopheles freeborni
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - mosquitoes
KW  - ovarian regulation of retention
KW  - retention of blood-meal
KW  - Other Control Measures (HH700) 
KW  - Animal Reproduction and Development (LL210) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sexual transmission of spotted fever group rickettsiae by infected male ticks: detection of rickettsiae in immature spermatozoa of Ixodes ricinus.
AU  - Hayes, S. F.
AU  - Burgdorfer, W.
AU  - Aeschlimann, A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1980///
VL  - 27
IS  - 2
SP  - 638
EP  - 642
SN  - 0019-9567
AD  - Hayes, S. F.: National Institute of Allergy and Infectious Diseases, Epidemology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19810582502.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Evidence from electron microscopy showed that the newly described 'Swiss agent', a spotted-fever group rickettsia, is incorporated into the reproductive cells of its male tick vector, Ixodes ricinus (L.). Rickettsiae were found in spermotogonia, spermatocytes, and maturing spermatids. The potential significance of these observations is briefly discussed in relation to published data on sexual transmission of rickettsiae by ticks.
KW  - sexual transmission
KW  - Acari
KW  - Ixodes ricinus
KW  - viruses
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Microtabiotes
KW  - spotted-fever rickettsiae
KW  - venereal transmission
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transmission of Plasmodium vivax from Vietnam by four different anophelines.
AU  - Collins, W. E.
AU  - Contacos, P. G.
AU  - Chin, W.
AU  - Jeter, M. H.
AU  - Briesch, P. E.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1980///
VL  - 29
IS  - 3
SP  - 473
EP  - 475
SN  - 0002-9637
AD  - Collins, W. E.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19800574758.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Infections of the SV-I strain of Plasmodium vivax from Vietnam were transmitted via the bites of infected Anopheles stephensi List., A. maculatus Theo. and A. balabacensis balabacensis Baisas. Infected salivary glands were also found in A. freeborni Aitken. In 18 successful transmissions, prepatent periods ranged from 10-17 days. Four black volunteers failed to develop infections even though they were fed upon by heavily infected A. maculatus and A. b. balabacensis.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Plasmodium vivax strain SV-1 from Vietnam was transmitted experimentally by Anopheles stephensi, A. maculatus and A. balabacensis balabacensis. Infected salivary glands were also found in A. freeborni mosquitoes. Prepatent periods in 18 transmissions ranged from 10 to 17 days. 4 Black volunteers resisted infection.
KW  - disease transmission
KW  - epidemiology
KW  - experimental infection
KW  - infectivity
KW  - mosquito nets
KW  - parasites
KW  - transmission
KW  - Anopheles balabacensis
KW  - Anopheles freeborni
KW  - Anopheles maculatus
KW  - Anopheles stephensi
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Plasmodium vivax
KW  - protozoa
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Anopheles balabacensis
KW  - Anopheles balabacensis balabacensis
KW  - experimental transmission
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ornithodoros (Alectorobius) amblus (Acarina: Ixodoidea: Argasidae): identity, marine bird and human hosts, virus infections, and distribution in Peru.
AU  - Clifford, C. M.
AU  - Hoogstraal, H.
AU  - Radovsky, F. J.
AU  - Stiller, D.
AU  - Keirans, J. E.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1980///
VL  - 66
IS  - 2
SP  - 312
EP  - 323
SN  - 0022-3395
AD  - Clifford, C. M.: National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19800574985.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Ornithodoros amblus Chamberlain was inadequately described from an adult of unstated sex from Peru. As part of a continuing attempt to stabilise species concepts in the group of O. capensis Neum., the adults of both sexes are here described, together with the nymph and larva, and criteria are presented for differentiating these stages from those of other members of the group in the Western Hemisphere. Examples were collected from 13 localities on the Pacific coast and on offshore islands of Peru. The bird hosts were species that do not migrate over long distances. The life-cycle of the tick was found to be typical of the O. capensis group; nymphs in the first instar did not necessarily feed. Man is eagerly attacked by O. amblus, and the consequences are severe inflammation and extremely intense pruritus; it is possible that more severe illness may also be caused by the attack. The viruses isolated from the ticks were Punta Salinas (Hughes serogroup) and Huacho (of the genus Orbivirus, Kemerovo subgroup, of the Reoviridae). Dense tick populations cause breeding birds to desert numerous nests, and the tick is thus economically important to the Peruvian guano industry. Spiders and lizards are thought to afford a considerable degree of control of O. amblus.
KW  - biology
KW  - bites
KW  - descriptions
KW  - groups
KW  - inflammation
KW  - natural enemies
KW  - predators
KW  - prey
KW  - pruritus
KW  - Peru
KW  - Acari
KW  - Araneae
KW  - arthropods
KW  - birds
KW  - Carios capensis
KW  - lizards
KW  - man
KW  - viruses
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - vertebrates
KW  - Chordata
KW  - Carios
KW  - Argasidae
KW  - Metastigmata
KW  - Acari
KW  - Sauria
KW  - reptiles
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - Ornithodoros
KW  - Andean Group
KW  - APEC countries
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - cape tampan
KW  - Huacho virus
KW  - itchiness
KW  - itching
KW  - Ornithodoros amblus
KW  - Ornithodoros capensis
KW  - Punta Salinas virus
KW  - seabird soft tick
KW  - spiders
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Tularemia.
AU  - Bell, J. F.
T2  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JO  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JF  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
Y1  - 1980///
SP  - 161
EP  - 193
CY  - Boca Raton, Florida; USA
PB  - Chemical Rubber Co. Press.
AD  - Bell, J. F.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19820590100.  Publication Type: Miscellaneous.  Language: English.  Number of References: 188 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2  - The author reviews the isolation and identification of the causal agent (Francisella tularensis) of tularaemia; the classification, morphology, culture and virulence of the organism; the clinical characteristics of the disease it causes in man and other animals; its epidemiology (including a list of mammal species known to be susceptible to infection); and transmission. Transmission is effected in various ways and the confirmed or assumed involvement of various groups of arthropods (including Diptera, Siphonaptera and Anoplura, but especially ticks) is discussed.
KW  - disease transmission
KW  - disease vectors
KW  - hosts
KW  - reviews
KW  - transmission
KW  - tularaemia
KW  - vectors
KW  - Wild animals
KW  - Zoonoses
KW  - Anoplura
KW  - Diptera
KW  - Francisella
KW  - Francisella tularensis
KW  - METASTIGMATA
KW  - Siphonaptera
KW  - Phthiraptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Francisellaceae
KW  - Thiotrichales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Francisella
KW  - Acari
KW  - Arachnida
KW  - bacterium
KW  - Ixodoidea
KW  - Schizomycetes
KW  - tularemia
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biological Resources (Animal) (PP710) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The spotted fever-group diseases.
AU  - Burgdorfer, W.
T2  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JO  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JF  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
Y1  - 1980///
SP  - 279
EP  - 300
CY  - Boca Raton, Florida; USA
PB  - Chemical Rubber Co. Press.
AD  - Burgdorfer, W.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19820590101.  Publication Type: Miscellaneous.  Language: English.  Number of References: 119 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Information is given on the causal agent, epidemiology, transmission, occurrence in man or other animals or both, clinical manifestations and world distribution of diseases of the spotted-fever group, caused by Rickettsia spp. These diseases include Rocky Mountain spotted fever, North Asian tick typhus, boutonneuse fever and Queensland tick typhus, all of which are transmitted by ticks, and rickettsial pox, which is transmitted by the mite Liponyssoides sanguineus (Hirst). The diagnosis, treatment, prevention and control of the diseases (including control of the arthropod vectors) are also briefly discussed.
KW  - disease transmission
KW  - Mediterranean spotted fever
KW  - reviews
KW  - Rocky Mountain spotted fever
KW  - transmission
KW  - man
KW  - METASTIGMATA
KW  - Rickettsia
KW  - Rickettsiales
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Liponyssoides
KW  - Dermanyssidae
KW  - Mesostigmata
KW  - mites
KW  - bacterium
KW  - boutonneuse fever
KW  - Ixodoidea
KW  - Liponyssoides sanguineus
KW  - Rickettsiaceae infections
KW  - rickettsial pox
KW  - tick typhus, North Asian
KW  - tick typhus, Queensland
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Scrub typhus.
AU  - Philip, R. N.
T2  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JO  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JF  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
Y1  - 1980///
SP  - 303
EP  - 315
CY  - Boca Raton, Florida; USA
PB  - Chemical Rubber Co. Press.
AD  - Philip, R. N.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19820590102.  Publication Type: Miscellaneous.  Language: English.  Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - In this review of scrub typhus, caused by Rickettsia tsutsugamushi, the topics dealt with include the morphology and life-cycle of R. tsutsugamushi, its hosts (mites of the genus Leptotrombidium and vertebrates, especially small mammals), the spread and epidemiology of the disease, its diagnosis and its prevention and control, particularly the use of repellents to provide protection from the mites and of chemical compounds to kill the mites.
KW  - disease transmission
KW  - disease vectors
KW  - hosts
KW  - reviews
KW  - scrub typhus
KW  - small mammals
KW  - transmission
KW  - vectors
KW  - Leptotrombidium
KW  - Orientia tsutsugamushi
KW  - Rickettsiales
KW  - Trombiculidae
KW  - Prostigmata
KW  - mites
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Orientia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - tsutsugamushi disease
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Typhus-group rickettsiae.
AU  - Philip, R. N.
T2  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JO  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JF  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
Y1  - 1980///
SP  - 317
EP  - 335
CY  - Boca Raton, Florida; USA
PB  - Chemical Rubber Co. Press.
AD  - Philip, R. N.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19820590103.  Publication Type: Miscellaneous.  Language: English.  Number of References: 111 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Information is presented on the 3 species of Rickettsia that comprise the typhus group: R. prowazekii, the agent of epidemic typhus, which is transmitted from man to man by Pediculus humanus humanus L.; R. typhi, the agent of murine typhus, the main vector of which is Xenopsylla cheopis (Roths.); and R. canada, which has been isolated from Haemaphysalis leporispalustris (Pack.) and is related to rickettsiae of the typhus group but has not yet been confirmed as pathogenic to man.
KW  - disease transmission
KW  - murine typhus
KW  - reviews
KW  - transmission
KW  - Haemaphysalis leporispalustris
KW  - man
KW  - Pediculus humanus
KW  - Rickettsia canadensis
KW  - Rickettsia prowazekii
KW  - Rickettsia typhi
KW  - Rickettsiales
KW  - Xenopsylla cheopis
KW  - Haemaphysalis
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Pediculus
KW  - Pediculidae
KW  - Anoplura
KW  - Phthiraptera
KW  - insects
KW  - Hexapoda
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Xenopsylla
KW  - Pulicidae
KW  - Siphonaptera
KW  - bacterium
KW  - body louse
KW  - flea-borne typhus
KW  - Oriental rat flea
KW  - Rickettsia canada
KW  - typhus, epidemic louse-borne
KW  - typhus-group rickettsiae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590103&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Q fever.
AU  - Stoenner, H. G.
T2  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JO  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JF  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
Y1  - 1980///
SP  - 337
EP  - 352
CY  - Boca Raton, Florida; USA
PB  - Chemical Rubber Co. Press.
AD  - Stoenner, H. G.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19820590104.  Publication Type: Miscellaneous.  Language: English.  Number of References: 89 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2  - Coxiella burnetii, the causal agent of Q fever was originally isolated from Dermacentor andersoni Stiles but has since been found naturally infecting 9 species of Dermacentor, 9 of Rhipicephalus, 10 of Haemaphysalis, 10 of Ixodes, 15 of Hyalomma, 4 of Amblyomma, 7 of Ornithodoros, 2 of Argas, 2 of Boophilus and Otobius megnini (Duges). Its presence has also been demonstrated in 12 species of mites and at least 3 species of fleas. The precise role of these arthropods in the epizootiology of Q fever among wildlife has not been clarified. The epidemiology of the disease, the species in which it occurs, its distribution, diagnosis, treatment prevention are reviewed.
KW  - disease transmission
KW  - disease vectors
KW  - hosts
KW  - Q fever
KW  - reviews
KW  - transmission
KW  - vectors
KW  - Amblyomma
KW  - Argas
KW  - Coxiella
KW  - Coxiella burnetii
KW  - Dermacentor
KW  - Dermacentor andersoni
KW  - Haemaphysalis
KW  - Hyalomma
KW  - Ixodes
KW  - mites
KW  - Ornithodoros
KW  - Otobius megnini
KW  - Rhipicephalus
KW  - Rickettsiales
KW  - Siphonaptera
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Argasidae
KW  - Coxiellaceae
KW  - Legionellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Coxiella
KW  - Dermacentor
KW  - Otobius
KW  - Alphaproteobacteria
KW  - insects
KW  - Hexapoda
KW  - abattoir fever
KW  - bacterium
KW  - Balkan grippe
KW  - Boophilus
KW  - Derrick-Burnet disease
KW  - ear tick
KW  - Nine Mile fever
KW  - pneumorickettsiosis
KW  - quadrilateral fever
KW  - query fever
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590104&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Rickettsioses of domestic animals not transmissible to man.
AU  - Stoenner, H. G.
T2  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JO  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
JF  - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II.
Y1  - 1980///
SP  - 353
EP  - 355
CY  - Boca Raton, Florida; USA
PB  - Chemical Rubber Co. Press.
AD  - Stoenner, H. G.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
N1  - Accession Number: 19820590105.  Publication Type: Miscellaneous.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Brief mention is made of a number of diseases of animals caused by rickettsial agents that do not affect man. These include heartwater (caused by Cowdria ruminantium and transmitted by Amblyomma spp.) affecting cattle, sheep and goats; tick-borne fever (caused by Ehrlichia phagocytophila and transmitted by Ixodes ricinus (L.)) affecting sheep and cattle; benign bovine rickettsiosis (caused by E. bovis and transmitted by Hyalomma spp.) affecting cattle; benign bovine rickettsiosis (caused by E. ovina and transmitted by Rhipicephalus bursa C. & F.) affecting sheep; and canine ehrlichiosis (caused by E. canis and transmitted by R. sanguineus (Latr.)), affecting dogs.
KW  - disease transmission
KW  - transmission
KW  - Amblyomma
KW  - Anaplasma bovis
KW  - Anaplasma phagocytophilum
KW  - cattle
KW  - DOGS
KW  - Ehrlichia canis
KW  - Ehrlichia ruminantium
KW  - GOATS
KW  - Hyalomma
KW  - Ixodes ricinus
KW  - Rhipicephalus bursa
KW  - Rhipicephalus sanguineus
KW  - Rickettsiales
KW  - sheep
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Ehrlichia
KW  - Anaplasmataceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - Capra
KW  - Ixodes
KW  - Rhipicephalus
KW  - Ovis
KW  - Anaplasma
KW  - bacterium
KW  - Cowdria ruminantium
KW  - Ehrlichia bovis
KW  - Ehrlichia ovina
KW  - Ehrlichia phagocytophila
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590105&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The burrow ink test and the scabies mite.
AU  - Woodley, D.
AU  - Saurat, J. H.
JO  - Journal of the American Academy of Dermatology
JF  - Journal of the American Academy of Dermatology
Y1  - 1981///
VL  - 4
IS  - 6
SP  - 715
EP  - 722
SN  - 0190-9622
AD  - Woodley, D.: Dermatology Branch, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19820595379.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The burrow ink test (BIT) has been routinely used to diagnose scabies [caused by Sarcoptes scabiei (L.)] at Hopital Saint-Louis, Paris, France. The diagnostic validity of the test was studied by performing a superficial shave biopsy on 25 BIT-positive and 30 BIT-negative scabietic papules from 17 scabies patients and examining the tissue with a light microscope. Microscopic evidence for scabies was found in 100% of BIT-positive lesions and in 36.6% of BIT-negative lesions. The BIT appears to be a valid diagnostic tool.
KW  - diagnosis
KW  - ectoparasitoses
KW  - scabies
KW  - France
KW  - Acari
KW  - man
KW  - mites
KW  - Sarcoptes scabiei
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Acari
KW  - Sarcoptes
KW  - Sarcoptidae
KW  - Astigmata
KW  - mites
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820595379&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serotypes of tick-borne spotted fever group rickettsiae from western California.
AU  - Philip, R. N.
AU  - Lane, R. S.
AU  - Casper, E. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1981///
VL  - 30
IS  - 3
SP  - 722
EP  - 727
SN  - 0002-9637
AD  - Philip, R. N.: Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19810585678.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A rickettsial survey of ixodid ticks known to bite man was conducted in 1979 in 4 coastal counties of California to obtain isolates from tick species that might be involved in the transmission of spotted fever-like illnesses, and to examine serological characteristics of the rickettsiae relative to defined members of the spotted fever group (SFG). One hundred and seventy (19.4%) of 877 ticks comprising 3 species were shown by the haemolymph test to harbour rickettsia-like organisms. A total of 85 SFG rickettsial isolates was obtained by Vero cell culture; 82 were from Dermacentor occidentalis Marx, 2 from D. variabilis (Say), and 1 from Ixodes pacificus Cooley & Kohls. As determined by microimmunofluorescence, the isolates comprised 4 distinct serotypes. Two serotypes were obtained only from D. occidentalis, and 1 each only from D. variabilis and I. pacificus. Most D. occidentalis isolates possessed the serological characteristics of Rickettsia rhipicephali, but 3 were similar to, yet distinguishable from, R. rickettsii and are members of an unclassified serotype referred to as 364D. The 2 isolates from D. variabilis resembled the unclassified 369C serotype previously shown to be associated with this species and D. andersoni Stiles elsewhere in the USA. The I. pacificus isolate was similar to strains of the unclassified Tillamook serotype isolated from this tick in several localities in western Oregon. Representative strains of the 4 serotypes could be distinguished on the basis of pathogenicity for Vero cells, chick embryos, guinea-pigs and/or meadow voles. The significance of these findings relative to the occurrence of tick-associated illnesses in western California is briefly discussed.
KW  - California
KW  - USA
KW  - Acari
KW  - Dermacentor occidentalis
KW  - Dermacentor variabilis
KW  - Ixodes pacificus
KW  - Rickettsia rhipicephali
KW  - Rickettsiales
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Dermacentor
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Ixodes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - spotted-fever rickettsiae
KW  - United States of America
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810585678&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Helical mycoplasmas (spiroplasmas) from Ixodes ticks.
AU  - Tully, J. G.
AU  - Rose, D. L.
AU  - Yunker, C. E.
AU  - Cory, J.
AU  - Whitcomb, R. F.
AU  - Williamson, D. L.
JO  - Science, USA
JF  - Science, USA
Y1  - 1981///
VL  - 212
IS  - 4498
SP  - 1043
EP  - 1045
AD  - Tully, J. G.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19810584288.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A new spiroplasma isolated from examples of Ixodes pacificus Cooley & Kohls collected in Oregon was found to be serologically and morphologically distinct from known spiroplasmas. The new spiroplasma could also be isolated in tick cell cultures. This discovery of a new fastidious mycoplasma in ticks presents opportunities to explore the possible role of these agents in human and animal diseases.
KW  - Oregon
KW  - USA
KW  - Acari
KW  - Ixodes pacificus
KW  - Mollicutes
KW  - Spiroplasmataceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Entomoplasmatales
KW  - Mollicutes
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - spiroplasmas
KW  - United States of America
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584288&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of an isolate of Rickettsia canada from California.
AU  - Philip, R. N.
AU  - Casper, E. A.
AU  - Anacker, R. L.
AU  - Peacock, M. G.
AU  - Hayes, S. F.
AU  - Lane, R. S.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1982///
VL  - 31
IS  - 6
SP  - 1216
EP  - 1221
SN  - 0002-9637
AD  - Philip, R. N.: Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19830599631.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 57-92-1.  Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - A strain of Rickettsia canada was recovered in 1980 from an adult of Haemaphysalis leporispalustris (Pack.) taken from a black-tailed jack rabbit (Lepus californicus) in Mendocino County, California. In all biological characteristics examined, this isolate, CA410, was indistinguishable from the prototype, strain 2678, isolated in Ontario, Canada, in 1963. These similarities include serological and immunological reactivity in laboratory mice and guinea-pigs, cultural characteristics in Vero cells, chick embryo cells and embryonated eggs, low pathogenicity for mice, meadow voles (Microtus pennsylvanicus) and guinea-pigs, unusual resistance to streptomycin, morphology by electron microscopy, and molar percentages of guanine plus cytosine of the deoxyribonucleic acids. Recovery of this 2nd strain in the same species of tick, but far removed in time and place from the origin of the prototype, provides evidence that R. canada is an established, ecologically stable, rickettsia in North America.
KW  - disease vectors
KW  - distribution
KW  - hosts
KW  - pathogenicity
KW  - resistance
KW  - rickettsial diseases
KW  - streptomycin
KW  - vectors
KW  - California
KW  - North America
KW  - USA
KW  - Acari
KW  - bacteria
KW  - guineapigs
KW  - Haemaphysalis leporispalustris
KW  - Lepus californicus
KW  - Metastigmata
KW  - mice
KW  - Microtus pennsylvanicus
KW  - Rickettsia canadensis
KW  - Rickettsiales
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - prokaryotes
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemaphysalis
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Lepus
KW  - Leporidae
KW  - Lagomorpha
KW  - Muridae
KW  - Microtus
KW  - Arvicolinae
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - guinea pigs
KW  - Rickettsia canada
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830599631&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection of Aedes aegypti with zygotes of Plasmodium gallinaceum fertilized in vitro.
AU  - Rosenberg, R.
AU  - Koontz, L. C.
AU  - Carter, R.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1982///
VL  - 68
IS  - 4
SP  - 653
EP  - 656
SN  - 0022-3395
AD  - Rosenberg, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19820597709.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology
N2  - In studies in the USA, it was found that female gametes of Plasmodium gallinaceum that had been fertilised in vitro, cleaned of all blood constituents, resuspended in blood and fed to females of Aedes aegypti (L.) through a membrane remained infective. At the lowest zygote concentration (104/ml), almost every ingested parasite produced an oocyst. As the concentration ingested increased, the efficiency diminished, and above 107 zygotes/ml, the number of oocysts produced was constant. This method should be of value to determine the nutrient requirements of the ookinete and early oocyst and to study the effect of immune sera on these stages in vitro.
KW  - disease vectors
KW  - in vitro fertilization
KW  - infection
KW  - infectivity
KW  - mosquito nets
KW  - parasites
KW  - techniques
KW  - vectors
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - infection techniques
KW  - mosquitoes
KW  - Plasmodium gallinaceum zygotes
KW  - sporogony in Aedes aegypti
KW  - Techniques and Methodology (ZZ900) 
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820597709&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Altered expression of Plasmodium knowlesi variant antigen on the erythrocyte membrane in splenectomized rhesus monkeys.
AU  - Barnwell, J. W.
AU  - Howard, R. J.
AU  - Miller, L. H.
JO  - Journal of Immunology
JF  - Journal of Immunology
Y1  - 1982///
VL  - 128
IS  - 1
SP  - 224
EP  - 226
AD  - Barnwell, J. W.: National Inst. of Allergy, National Institutes of Health, Bethesda, MD 10105, USA.
N1  - Accession Number: 19820894077.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Protozoology
N2  - Variant antigens are present on the surface of Plasmodium knowlesi infected erythrocytes as detected by the schizont-infected cell agglutination (SICA) assay. Parasitized erythrocytes passaged in splenectomized monkeys did not agglutinate with immune sera. On the first passage from intact to splenectomized monkeys, the SICA titres decreased 4- to 16-fold; after the 2nd and subsequent passages in splenectomized monkeys, the infected cells became non-agglutinable to all sera tested, including sera from animals infected with the non-agglutinating parasites. This loss of agglutinability could have resulted from selection of a genetically distinct subpopulation of the original parasites or the ability of the original parasites to alter their phenotypic expression. The new nonagglutinable phenotype is designated SICA [-], and the agglutinable phenotype, SICA [+]. The loss of agglutinability indicates that the variant antigen normally expressed on the erythrocyte membrane of infected cells is altered or absent. Because SICA [-] parasites developed in the absence of the spleen, the major organ of host defence against malaria, then this organ may in some manner influence or modulate antigenic expression in P. knowlesi and possibly other malaria parasites. [AS]
KW  - immunology
KW  - parasites
KW  - spleen
KW  - Macaca mulatta
KW  - Plasmodium knowlesi
KW  - Primates
KW  - protozoa
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - antigenic expression
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820894077&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lyme disease - a tick-borne spirochetosis?.
AU  - Burgdorfer, W.
AU  - Barbour, A. G.
AU  - Hayes, S. F.
AU  - Benach, J. L.
AU  - Grunwaldt, E.
AU  - Davis, J. P.
JO  - Science, USA
JF  - Science, USA
Y1  - 1982///
VL  - 216
IS  - 4552
SP  - 1317
EP  - 1319
AD  - Burgdorfer, W.: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19820595479.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - During a laboratory study carried out in the USA, a Treponema-like spirochaete was detected in and isolated from adults of Ixodes dammini Spielman, Clifford, Piesman & Corwin, the incriminated vector of Lyme disease, collected by flagging in New York State. Long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10-12 weeks after infected ticks had fed on them may have been causally related to the spirochaetes. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to the spirochaete. The results suggested that the newly discovered spirochaete may be involved in the aetiology of Lyme disease.
KW  - aetiology
KW  - arthritis
KW  - New York
KW  - USA
KW  - Acari
KW  - bacteria
KW  - Ixodes scapularis
KW  - man
KW  - Spirochaetales
KW  - Treponema
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Spirochaetes
KW  - Bacteria
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - causal agents
KW  - etiology
KW  - Ixodes dammini
KW  - possibly causing Lyme disease
KW  - Schizomycetes
KW  - spirochaete implicated
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820595479&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of antigens on mosquito midgut stages of Plasmodium gallinaceum. I. Zygote surface antigens.
AU  - Kaushal, D. C.
AU  - Carter, R.
AU  - Howard, R. J.
AU  - McAuliffe, F. M.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1983///
VL  - 8
IS  - 1
SP  - 53
EP  - 69
SN  - 0166-6851
AD  - Kaushal, D. C.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19840517842.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - The surface protein antigens on zygotes of Plasmodium gallinaceum were defined using radioiodination methods and rabbit anti-zygote serum, which blocks transmission of the parasite to Aedes aegypti (L.).
KW  - Antigens
KW  - disease vectors
KW  - Immunology
KW  - mosquito nets
KW  - parasites
KW  - Proteins
KW  - surface antigens
KW  - vectors
KW  - zygotes
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - antigenicity
KW  - immunogens
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840517842&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Isolation of a cultivable spirochete from Ixodes ricinus ticks of Switzerland.
AU  - Barbour, A. G.
AU  - Burgdorfer, W.
AU  - Hayes, S. F.
AU  - Péter, O.
AU  - Aeschlimann, A.
JO  - Current Microbiology
JF  - Current Microbiology
Y1  - 1983///
VL  - 8
IS  - 2
SP  - 123
EP  - 126
SN  - 0343-8651
AD  - Barbour, A. G.: Laboratory of Microbial Structure and Function, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19840515889.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A cultivable spirochaete was isolated from adults of Ixodes ricinus (L.) collected from an area of Switzerland where erythema chronicum migrans, a tick-borne inflammatory disorder, is endemic. The spirochaete was very similar in its morphology, polyacrylamide-gel-electrophoresis profile and antigenic determinants to one previously isolated from I. dammini Spielman, Clifford, Piesman & Corwin in the USA.
KW  - disease vectors
KW  - distribution
KW  - vectors
KW  - Switzerland
KW  - Acari
KW  - bacteria
KW  - Ixodes ricinus
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - Developed Countries
KW  - EFTA
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - bacterium
KW  - Schizomycetes
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840515889&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Erythema chronicum migrans -- a tickborne spirochetosis.
AU  - Burgdorfer, W.
AU  - Barbour, A. G.
AU  - Hayes, S. F.
AU  - Peter, O.
AU  - Aeschlimann, A.
JO  - Acta Tropica
JF  - Acta Tropica
Y1  - 1983///
VL  - 40
IS  - 1
SP  - 79
EP  - 83
SN  - 0001-706X
AD  - Burgdorfer, W.: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19830501546.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Erythema chronicum migrans (ECM) in man is characterised by the formation of a small annular papule that expands centrifugally with an indurated border 0.5-2 cm wide and central clearing. It has been reported throughout Europe, Ixodes ricinus (L.) being the suspected vector of a presumed pathogen. A condition indistinguishable from ECM was first observed in the USA (Wisconsin) in 1970. Clinical and epidemiological investigations at Lyme, Connecticut, led to the description of Lyme disease, an epidemic inflammatory disorder that usually begins with ECM and may be followed months later with severe neurological, cardiac or arthritic syndromes. I. dammini Spielman, Clifford, Piesman & Corwin is thought to be vector of the presumed pathogen in the north-eastern and mid-western USA and I. pacificus Cooley & Kohls in the west. A cultivable spirochaete recently isolated from I. dammini from Shelter I., New York (an area known for the occurrence of Lyme disease), produced symptoms resembling ECM in rabbits, and a morphologically indistinguishable spirochaete was subsequently recovered from the blood of 2 patients with Lyme disease. The authors report that 73 of 201 examples of I. ricinus collected in spring 1982 on the east shore of Lake Neuchatel, Bern, Switzerland (where ECM has occurred sporadically), were found to be infected with a spirochaete morphologically and immunologically indistinguisable from that isolated from I. dammini. It appears that the spirochaete is the aetiological agent both of Lyme disease in the USA and of ECM in Europe. Studies are in progress to determine the development of the pathogen in Ixodes and to clarify the transmission mechanism(s).
KW  - arthritis
KW  - disease vectors
KW  - distribution
KW  - erythema chronicum migrans
KW  - hosts
KW  - Lyme disease
KW  - vectors
KW  - New York
KW  - Switzerland
KW  - USA
KW  - Acari
KW  - bacteria
KW  - Ixodes pacificus
KW  - Ixodes ricinus
KW  - Ixodes scapularis
KW  - man
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - EFTA
KW  - Western Europe
KW  - Europe
KW  - bacterium
KW  - Ixodes dammini
KW  - lyme borreliosis
KW  - Schizomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody.
AU  - Barbour, A. G.
AU  - Tessier, S. L.
AU  - Todd, W. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1983///
VL  - 41
IS  - 2
SP  - 795
EP  - 804
SN  - 0019-9567
AD  - Barbour, A. G.: Laboratory of Microbial Structure & Function, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19842011158.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - Ixodid tick-associated spirochetes have been implicated as the etiological agents of Lyme disease. We raised a murine monoclonal antibody (H5332) against a spirochete, strain B31, isolated from Ixodes dammini ticks. In indirect immunofluorescence assays and western blot analyses, H5332 reacted with whole cells or isolated components of not only strain B31 but also spirochetes isolated from Ixodes ricinus ticks, a field mouse, a raccoon, and patients with Lyme disease. In contrast, H5332 did not bind to representative borreliae, treponemes, and leptospires. Using indirect immunofluorescence assays and immune electron microscopy, we found the H5332 determinant to be diffusely distributed over the surface of prefixed spirochetes but to be aggregated in patches when the organisms were incubated with H5332 and a second ligand before fixation. Radioimmunoprecipitation and western blot studies revealed the H5332 determinant to be either on or tightly associated with an abundant outer membrane protein with an apparent subunit molecular weight of 31 000.AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Spirochaetes associated with ixodid ticks have been implicated as the aetiological agents of Lyme disease. The murine monoclonal antibody H5332 against the spirochaete strain B31 was isolated from Ixodes dammini Spielman, Clifford, Piesman & Corwin. The antibody reacted with whole cells or isolated components of B31 and with spirochaetes isolated from I. ricinus (L.), a white-footed mouse [Peromyscus leucopus], a raccoon and patients with Lyme disease. The H5332 determinant was found to be diffusely distributed over the surface of prefixed spirochaetes, but to be aggregated in patches when the organisms were incubated with H5332 and a second ligand before fixation. The H5332 determinant was either on or tightly associated with an abundant outer membrane protein with an apparent subunit molecular weight of 31 000.
KW  - aetiology
KW  - antigens
KW  - disease vectors
KW  - Lyme disease
KW  - surface antigens
KW  - surfaces
KW  - vectors
KW  - Acari
KW  - Ixodes scapularis
KW  - Metastigmata
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - causal agents
KW  - due to spirochaete from Ixodes dammini
KW  - etiology
KW  - immunogens
KW  - Infectious arthritis
KW  - Ixodes dammini
KW  - lyme borreliosis
KW  - Schizomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Evidence that anti-idiotype induced immunity to experimental African trypanosomiasis is genetically restricted and requires recognition of combining site-related idiotypes.
AU  - Sacks, D. L.
AU  - Sher, A.
JO  - Journal of Immunology
JF  - Journal of Immunology
Y1  - 1983///
VL  - 131
IS  - 3
SP  - 1511
EP  - 1515
AD  - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19840176219.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 308067-57-4.  Subject Subsets: Animal Breeding; Tropical Diseases
N2  - Of 3 allogeneic anti-idiotype antibodies raised against 3 protective monoclonal antibodies, each with specificity for the variant surface antigen of a clone of Trypanosoma rhodesiense, only 1 (anti-7H11 Id) was effective in immunizing BALB/c mice against homologous challenge. The immunity was restricted to mice bearing genes linked to Igh-Ca, which appeared to control expression of this idiotype, both in response to infection and anti-idiotype treatment. Another idiotype, 11D5, appeared to be under similar genetic control.
KW  - antibodies
KW  - Disease resistance
KW  - experimental infections
KW  - genes
KW  - idiotypes
KW  - Immunogenetics
KW  - immunoglobulins
KW  - immunology
KW  - mice
KW  - Trypanosoma
KW  - Trypanosoma brucei
KW  - Trypanosoma rhodesiense
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - Trypanosoma
KW  - gamma-globulins
KW  - Igh-Ca restriction
KW  - immune globulins
KW  - resistance to disease
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bacteriophage in the Ixodes dammini spirochete, etiological agent of Lyme disease.
AU  - Hayes, S. F.
AU  - Burgdorfer, W.
AU  - Barbour, A. G.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1983///
VL  - 154
SP  - 1436
EP  - 1439
SN  - 0021-9193
AD  - Hayes, S. F.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19840515016.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The authors describe a bacteriophage detected by electron microscopy in the USA in a spirochaete isolated from the tick Ixodes dammini Spielman, Clifford, Piesman & Corwin. The spirochaete is the causal agent of Lyme disease.
KW  - bacteriophages
KW  - disease vectors
KW  - Lyme disease
KW  - vectors
KW  - USA
KW  - Acari
KW  - Ixodes scapularis
KW  - Spirochaetaceae
KW  - viruses
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - infectious arthritis
KW  - Ixodes dammini
KW  - lyme borreliosis
KW  - phages
KW  - Schizomycetes
KW  - United States of America
KW  - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Derivatizing reagents for high-performance liquid chromatography detection of peptides at the picomole level.
AU  - Meek, J. L.
JO  - Journal of Chromatography
JF  - Journal of Chromatography
Y1  - 1983///
VL  - 266
SP  - 401
EP  - 408
SN  - 0021-9673
AD  - Meek, J. L.: Lab. Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC 20032, USA.
N1  - Accession Number: 19841451696.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
KW  - Peptides
KW  - separation
KW  - separating
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vertical transmission of spotted fever group and scrub typhus rickettsiae.
AU  - Burgdorfer, W.
JO  - Current Topics in Vector Research
JF  - Current Topics in Vector Research
Y1  - 1984///
VL  - 2
SP  - 77
EP  - 92
CY  - New York; USA
PB  - Praeger Publishers
SN  - 003071611X
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19920512059.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - This review examines transovarian transmission of Rickettsia rickettsii and other spotted fever group (SFG) rickettsiae, venereal transmission of SFG rickettsiae, and transovarian transmission of R. tsutsugamushi.
KW  - disease vectors
KW  - Reviews
KW  - Sexual transmission
KW  - Transovarial transmission
KW  - vertical transmission
KW  - Acari
KW  - Ixodidae
KW  - Orientia tsutsugamushi
KW  - Rickettsia
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Trombiculidae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Metastigmata
KW  - Acari
KW  - Orientia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Rickettsia
KW  - Prostigmata
KW  - mites
KW  - bacterium
KW  - Rickettsia tsutsugamushi
KW  - venereal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920512059&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-lymphotropic retroviruses in adult T-cell leukemia-lymphoma and acquired immune deficiency syndrome.
AU  - Sarin, P. S.
AU  - Gallo, R. C.
JO  - Journal of Clinical Immunology
JF  - Journal of Clinical Immunology
Y1  - 1984///
VL  - 4
IS  - 6
SP  - 415
EP  - 423
SN  - 0271-9142
AD  - Sarin, P. S.: Lab. of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19862029136.  Publication Type: Journal Article.  Language: English.  Number of References: 69 ref.
KW  - AIDS HTLV clinical
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Simplified estimation technique for organic contaminant transport in groundwater.
AU  - Piver, W. T.
AU  - Lindstrom, F. T.
JO  - Journal of Hazardous Materials
JF  - Journal of Hazardous Materials
Y1  - 1984///
VL  - 8
IS  - 4
SP  - 331
EP  - 339
SN  - 0304-3894
AD  - Piver, W. T.: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19851994719.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 7732-18-5.  Subject Subsets: Soils & Fertilizers
N2  - The analytical solution for one-dimensional dispersive-advective transport of a single solute in a saturated soil accompanied by adsorption onto soil surfaces and first-order reaction rate kinetics for degradation can be used to evaluate the suitability of potential sites for burial of organic chemicals. The technique can be used to the greatest advantage with organic chemicals that are present in groundwaters in small amounts. The steady-state solution provides a rapid method for chemical landfill site evaluation because it contains the important variables that describe interactions between hydrodynamics and chemical transformation. With this solution, solute concentration, at a specified distance from the landfill site, is a function of the initial concentration and two dimensionless groups. In the first group, the relative weights of advective and dispersive variables are compared, and in the second group the relative weights of hydrodynamic and degradation variables are compared. The ratio of hydrodynamic to degradation variables can be rearranged and written as (aL.λ)/(q/ε), where aL is the dispersivity of the soil, λ is the reaction rate constant, q is groundwater flow velocity, and ε is the soil porosity. When this term has a value less than 0.01, the degradation process is occurring at such a slow rate relative to the hydrodynamics that it can be neglected. Under these conditions the site is unsuitable because the chemicals are unreactive, and concentrations in groundwaters will change very slowly with distance away from the landfill site.
KW  - hydrodynamic dispersion
KW  - landfills
KW  - models
KW  - organic compounds
KW  - POLLUTION
KW  - soil
KW  - transport processes
KW  - water
KW  - environmental pollution
KW  - organic chemicals
KW  - soil transport processes
KW  - transport processes in soil systems
KW  - Pollution and Degradation (PP600) 
KW  - Engineering and Equipment (General) (NN000) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Soil Chemistry and Mineralogy (JJ200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A checklist of types of Ixodoidea (Acari) in the collection of the Rocky Mountain Laboratories.
AU  - Keirans, J. E.
AU  - Clifford, C. M.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1984///
VL  - 21
IS  - 3
SP  - 310
EP  - 320
SN  - 0022-2585
AD  - Keirans, J. E.: National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19840517820.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - The Rocky Mountain tick collection contains over 160 000 separate collections, including about 740 of the 850 described species worldwide and about 300 types. A checklist of the types is presented.
KW  - taxonomy
KW  - type specimens
KW  - North America
KW  - USA
KW  - Acari
KW  - Argasidae
KW  - Ixodidae
KW  - Metastigmata
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Metastigmata
KW  - Acari
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - Rocky Mountain Laboratories
KW  - systematics
KW  - type collection
KW  - United States of America
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Biological Resources (Animal) (PP710) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The constancy of parent-offspring similarity of total cholesterol throughout childhood and early adult life. The Lipid Research Clinics Program Prevalence Study.
AU  - Greenberg, R. A.
AU  - Green, P. P.
AU  - Roggenkamp, K. J.
AU  - Barrett-Connor, E.
AU  - Tyroler, H. A.
AU  - Heiss, G.
JO  - Journal of Chronic Diseases
JF  - Journal of Chronic Diseases
Y1  - 1984///
VL  - 37
IS  - 11
SP  - 833
EP  - 838
AD  - Greenberg, R. A.: Lipid Metabolism - Atherogenesis Branch, National Heart, Lung and Blood Institute, NIH, Federal Building, Room 402, Bethesda, MD 20205, USA.
N1  - Accession Number: 19851469596.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - In a cross-sectional study of 11 409 white parent-offspring pairs in 5 North American populations, the effect of age of the offspring on parent-offspring total cholesterol correlations was examined. In general there was no difference in correlations by age of the offspring for the 4 types (by gender) of parent-offspring pairs. That was true within each of the 5 populations and for the average of all populations combined. For offspring from less than 2 to 29 years old, those average age-specific correlations ranged from 0.17 to 0.42. Despite the considerable physiological and environmental changes which influence cholesterol values from birth to early adulthood, the strength of parent-offspring similarity shows no consistent pattern of change.
KW  - blood
KW  - cholesterol
KW  - correlation
KW  - Parents
KW  - progeny
KW  - North America
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rickettsia conorii isolated from Rhipicephalus sanguineus introduced into Switzerland on a pet dog.
AU  - Péter, O.
AU  - Burgdorfer, W.
AU  - Aeschlimann, A.
AU  - Chatelanat, P.
JO  - Zeitschrift für Parasitenkunde
JF  - Zeitschrift für Parasitenkunde
Y1  - 1984///
VL  - 70
IS  - 2
SP  - 265
EP  - 270
AD  - Péter, O.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19842011036.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Veterinary Science
N2  - Four people near Geneva, Switzerland, developed a febrile illness during 1980 and 1981 that was diagnosed clinically as boutonneuse fever; all the patients had been in contact with a pet dog which is thought to have introduced the brown dog tick, Rhipicephalus sanguineus into the area from either southern France or Italy in 1976. All the rooms of the house in which the dog lived were infested with ticks and 40% of 75 nymphs and adults examined were infected with a rickettsial agent "biologically and antigenically indistinguishable from Rickettsia conorii".Carolyn A. Brown&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A survey in a household near Geneva, Switzerland, revealed that 30 (40%) of 75 nymphs and adults of Rhipicephalus sanguineus were infected with a rickettsial agent biologically and antigenically indistinguishable from Rickettsia conorii, the causal agent of boutonneuse fever. Introduced in 1976 from either southern France or Italy by the family's pet dog, the tick infestation had increased steadily until 1981, when control measures were initiated. During 1980-81, 4 persons associated with the dog contracted a febrile illness diagnosed as boutonneuse fever.
KW  - disease vectors
KW  - distribution
KW  - dog diseases
KW  - hosts
KW  - Mediterranean spotted fever
KW  - pets
KW  - rickettsial diseases
KW  - Tick infestations
KW  - tickborne diseases
KW  - typhus fevers
KW  - vectors
KW  - Europe
KW  - Switzerland
KW  - Acari
KW  - dogs
KW  - man
KW  - Metastigmata
KW  - Rhipicephalus
KW  - Rhipicephalus sanguineus
KW  - Rickettsia
KW  - Rickettsia conorii
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Acari
KW  - Ixodidae
KW  - Metastigmata
KW  - Rhipicephalus
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Rickettsia
KW  - Developed Countries
KW  - EFTA
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - bacterium
KW  - boutonneuse fever
KW  - conorii
KW  - pet animals
KW  - Rickettsia vector
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pets and Companion Animals (LL070) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19842011036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ticks. An ever increasing public health menace.
AU  - Burgdorfer, W.
JO  - Bulletin, Connecticut Agricultural Experiment Station
JF  - Bulletin, Connecticut Agricultural Experiment Station
Y1  - 1984///
IS  - 822
SP  - 6
EP  - 6
AD  - Burgdorfer, W.: Department of Health & Human Services, National Institutes of Health, National Institute of Allergy & Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19850525857.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The importance of ticks as vectors of disease pathogens is reviewed and discussed with particular reference to diseases affecting man in the USA. They include babesiosis (caused by Babesia microti, which is transmitted by Ixodes dammini), Lyme disease (caused by a spirochaete, which is also transmitted by I. dammini), erythema chronicum migrans, which is caused by the bite of Ixodes ricinus, and Rocky Mountain spotted fever (caused by Rickettsia rickettsii, which is transmitted by Dermacentor andersoni).
KW  - bites
KW  - disease transmission
KW  - disease vectors
KW  - hosts
KW  - human diseases
KW  - Lyme disease
KW  - reviews
KW  - transmission
KW  - vectors
KW  - USA
KW  - Acari
KW  - Apicomplexa
KW  - Babesia microti
KW  - Dermacentor andersoni
KW  - Ixodes ricinus
KW  - Ixodes scapularis
KW  - man
KW  - METASTIGMATA
KW  - Rickettsia rickettsii
KW  - Rickettsiales
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Babesia
KW  - Babesiidae
KW  - Piroplasmorida
KW  - Apicomplexa
KW  - Dermacentor
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Ixodes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - Ixodes dammini
KW  - Ixodoidea
KW  - lyme borreliosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of ATP analogues on the gorging response of Aedes aegypti.
AU  - Galun, R.
AU  - Koontz, L. C.
AU  - Gwadz, R. W.
AU  - Ribeiro, J. M. C.
JO  - Physiological Entomology
JF  - Physiological Entomology
Y1  - 1985///
VL  - 10
IS  - 3
SP  - 275
EP  - 281
SN  - 0307-6962
AD  - Galun, R.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, USA.
N1  - Accession Number: 19850529624.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 303-81-1.  Subject Subsets: Medical & Veterinary Entomology
N2  - The ATP analogues adenylylimidodiphosphate and adenylylmethylenediphosphate were 3-5 times as effective as ATP as gorging stimulants for Aedes aegypti. This increased potency was not due to the fact that the 2 analogues are not hydrolysed by the mosquito salivary apyrase, but most likely to their greater affinity to the mosquito gustatory receptor protein. The analogues 2′d ATP and 3′d ATP were about half as potent as ATP, while 2′,3′-dideoxyadenosine triphosphate was 10 times as potent as ATP in evoking the gorging response. It is proposed that removal of both hydroxyl groups eliminates binding of the stimulant at the ribose moeity, thus allowing the molecule greater freedom to rotate and bind more effectively to its other 2 binding sites at the amino group on the purine and at the terminal phosphate. The data demonstrate that ATP activates the gorging response of A. aegypti merely by binding to its receptor protein and is not required as an exogenous source of energy. The gorging response to ATP is competitively inhibited by novobiocin.
KW  - effects
KW  - feeding
KW  - mosquito nets
KW  - Novobiocin
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Adenosine 5'-(tetrahydrogen triphosphate)
KW  - ATP analogues
KW  - inhibiting gorging response to ATP
KW  - mosquitoes
KW  - Other Control Measures (HH700) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Polymorphism of the 3′ open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III.
AU  - Ratner, L.
AU  - Starcich, B.
AU  - et al.
AU  - Josephs, S. F. (
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1985///
VL  - 13
IS  - 22
SP  - 8219
EP  - 8229
SN  - 0305-1048
AD  - Ratner, L.: Lab. of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862026840.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Public Health
KW  - human immunodeficiency viruses
KW  - open reading frames
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - 3' polymorphism
KW  - human immunodeficiency virus
KW  - ORFs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026840&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Laboratory assessment of a species-specific radioimmunoassay for the detection of malaria sporozoites in mosquitoes (Diptera: Culicidae).
AU  - Collins, F. H.
AU  - Gwadz, R. W.
AU  - Koontz, L. C.
AU  - Zavala, F.
AU  - Nussenzweig, R. S.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1985///
VL  - 22
IS  - 2
SP  - 121
EP  - 129
SN  - 0022-2585
AD  - Collins, F. H.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19850529414.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology
N2  - A radioimmunoassay using monoclonal antibodies (Mabs) specific for the dominant surface antigens of malaria sporozoites was used in the laboratory in the USA to evaluate various factors that might influence the use of similar tests for epidemiological studies. Mabs specific for sporozoites of 2 causal agents of simian malaria, Plasmodium knowlesi and P. cynomolgi, were used to determine the time of antigen appearance and persistence in Anopheles dirus, the conditions under which infected mosquitoes could be stored before processing, and methods of detecting infected mosquitoes in pools or of identifying pools including mosquitoes with more than 1 species of malaria pathogen.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A radioimmunoassay (RIA) using monoclonal antibodies (Mabs) specific for the dominant surface antigens of malaria sporozoites was used to evaluate various factors that might influence the use of this or similar tests for epidemiological studies. Mabs specific for sporozoites of 2 simian malaria organisms, Plasmodium knowlesi and P. cynomolgi, were used to determine the time of antigen appearance and persistence in mosquitoes, conditions under which infected mosquitoes can be stored prior to processing, and methods for detecting infected mosquitoes in pools or for identifying pools including mosquitoes carrying more than 1 species of malaria.AS
KW  - detection
KW  - disease vectors
KW  - immunodiagnosis
KW  - infection
KW  - monoclonal antibodies
KW  - mosquito nets
KW  - parasites
KW  - radioimmunoassay
KW  - sporozoites
KW  - Techniques
KW  - vectors
KW  - USA
KW  - Anopheles
KW  - Anopheles dirus
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Insects
KW  - Plasmodium
KW  - Plasmodium cynomolgi
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Protozoa
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Haemosporida
KW  - immunoradiometric assay
KW  - mosquitoes
KW  - radioimmunosorbent assay
KW  - recovery from infected mosquitoes
KW  - serological diagnosis
KW  - sporozoite detection
KW  - United States of America
KW  - Techniques and Methodology (ZZ900) 
KW  - Other Control Measures (HH700) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850529414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of lysis-centrifugation (Isolator) and radiometric (BACTEC) blood culture systems for the detection of mycobacteremia.
AU  - Gill, V. J.
AU  - Park, C. H.
AU  - Stock, F.
AU  - Gosey, L. L.
AU  - Witebsky, F. G.
AU  - Masur, H.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1985///
VL  - 22
IS  - 4
SP  - 543
EP  - 546
SN  - 0095-1137
AD  - Gill, V. J.: Microbiology Service, Dept of Clinical Pathology, Clinical Center, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19862027265.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors compared the sensitivity of a radiometric (BACTEC system) liquid medium culture system with that of conventional solid mycobacterial culture media for cultures of blood from these patients. Both systems were inoculated with blood concentrate prepared by lysis-centrifugation (Isolator). Of 46 AIDS patients whose blood was cultured, 28% had cultures positive for Mycobacterium avium-intracellulare (MAI). Patients had from &lt;1 to &gt;100 MAI colonies/ml of blood. Lowenstein-Jensen and Middlebrook 7H11 agars were comparable for recovery of MAI. BACTEC 12A vials containing double the standard volume of medium (4 ml) were more sensitive and were positive slightly earlier than vials containing the standard volume (2 ml). Conventional media detected 98% of positive cultures; BACTEC vials containing double volumes of medium detected 94% of positive cultures, whereas single-volume vials detected 77%. BACTEC vials were positive about 5-6 days sooner than slants or plates containing conventional media. For a few cultures, the authors compared the use of unconcentrated blood with Isolator-concentrated blood with each of these as inocula for BACTEC vials. Results for these cultures suggested that, although the use of Isolator-concentrated blood resulted in greater sensitivity than the use of unconcentrated blood would, the use of unconcentrated blood would still result in the detection of at least 78% of positive cultures.J.K. Schönfeld
KW  - acquired immune deficiency syndrome
KW  - blood
KW  - culture techniques
KW  - detection
KW  - infections
KW  - mycobacterial diseases
KW  - systems
KW  - USA
KW  - Mycobacterium
KW  - Mycobacterium avium complex
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - bacterium
KW  - mycobacterial infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Brunfelsamidine: a novel convulsant from the medicinal plant Brunfelsia grandiflora.
AU  - Lloyd, H. A.
AU  - Fales, H. M.
AU  - Goldman, M. E.
AU  - Jerina, D. M.
AU  - Plowman, T.
AU  - Schultes, R. E.
JO  - Tetrahedron Letters
JF  - Tetrahedron Letters
Y1  - 1985///
VL  - 26
IS  - 22
SP  - 2623
EP  - 2624
SN  - 0040-4039
AD  - Lloyd, H. A.: National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19850330387.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Horticultural Science
N2  - The convulsant, isolated from root bark collected in Peru, was characterized as pyrrole-3-carboxamidine.
KW  - medicinal plants
KW  - plant composition
KW  - Peru
KW  - Brunfelsia
KW  - Solanaceae
KW  - Solanales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Andean Group
KW  - APEC countries
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Brunfelsia grandiflora
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Science (General) (FF000) 
KW  - Plant Composition (FF040) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevalence of HTLV-I an arctic regions.
AU  - Robert-Guroff, M.
AU  - Clark, J.
AU  - et al.
AU  - Lanier, A. P. (
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1985///
VL  - 36
IS  - 6
SP  - 651
EP  - 655
SN  - 0020-7136
AD  - Robert-Guroff, M.: National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862026910.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Sera of native inhabitants of Arctic regions were assayed for antibodies to HTLV-I by the ELISA technique followed by competition experiments to confirm antibody specificity. Residents of 7 widely separated Alaskan villages exhibited prevalence rates of 0 to 12% for HTLV-I antibodies. Less than 1% of Greenland Eskimos were HTLV-I antibody-positive. Residents of 3 northern Swedish regions ranged in HTLV-I antibody prevalence from 0 to 5%. Sera of healthy native inhabitants of Alaska and northern Sweden were similarly assayed for antibodies to HTLV-II. No additional sera were shown to be positive for HTLV-II antibodies. While some of the HTLV-I antibody-positive sera exhibited cross-reactivity with HTLV-II antigens, competition experiments using disrupted HTLV-II or purified HTLV-I p24 as test antigens indicated that the primary antibody response in all cases tested was elicited by HTLV-I. [The authors'] results show that HTLV-I distribution is not restricted to endemic areas in warm, humid climates, but extends to Arctic regions. Within these regions, HTLV-I exhibits the same restricted distribution seen in other areas where virus infection is prevalent. The Arctic does not seem to be a reservoir for HTLV-II infection. The origin of HTLV-I in Arctic areas is not known. One may speculate that foreign visitors introduced the virus into Aleut and Lapp populations, and that it has been maintained there and restricted in its distribution as a result of close familial relationships.AS
KW  - HTLV infections
KW  - Alaska
KW  - Europe
KW  - Greenland
KW  - North America
KW  - Sweden
KW  - USA
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - European Union Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Arctic populations
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026910&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clonal analysis of T lymphocytes in the acquired immunodeficiency syndrome: evidence for an abnormality affecting individual helper and suppressor T cells.
AU  - Margolick, J. B.
AU  - Volkman, D. J.
AU  - Lane, H. C.
AU  - Fauci, A. S.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1985///
VL  - 76
IS  - 2
SP  - 709
EP  - 715
SN  - 0021-9738
AD  - Margolick, J. B.: National Institutes of Health, Bldg 10, Rm 11B-13, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862026294.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Studies on peripheral blood mononuclear cells from patients with AIDS have only just begun to resolve the question of whether the immune abnormalities are secondary to abnormal proportions or numbers of cells or intrinsic functional defects. This study examines the function of cloned rather than heterogeneous T-cell populations in 8 patients with AIDS compared to 8 healthy heterosexual control subjects. Purified T4 and T8 cells from patients with AIDS gave rise to about 85% fewer clones, compared to the controls. This abnormality could not be attributed to variability in circulating numbers. This suggests an intrinsic defect in their ability to proliferate and expand clonally. However, the cloned T-cells from AIDS patients demonstrated normal proliferative responses to phytohaemagglutinin and alloantigen and normal help and suppression in a pokeweed mitogen-driven IgG synthesis assay. This functional abnormality, since it affects both T4 and T8 cells is unlikely to be due to a direct infection with HTLV-III. The possible roles of other infectious agents, activation states and depletion of more clonable T-cell subpopulations are discussed.I.V.D. Weller
KW  - acquired immune deficiency syndrome
KW  - immunology
KW  - AIDS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026294&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-III in homosexual men: selective loss of an influenza-specific, human leukocyte antigen-restricted cytotoxic T lymphocyte response in human T lymphotropic virus-III positive individuals with symptoms of acquired immunodeficiency syndrome and in a patient with acquired immunodeficiency syndrome.
AU  - Shearer, G. M.
AU  - Salahuddin, S. Z.
AU  - et al.
AU  - Markham, P. D. (
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1985///
VL  - 76
IS  - 4
SP  - 1699
EP  - 1704
SN  - 0021-9738
AD  - Shearer, G. M.: Immunology Branch and Laboratory of Tumor Cell Biology of the National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862026962.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Peripheral blood leucocytes from 18 homosexual men and 9 heterosexual male control subjects repeatedly tested over a 2-year period for the presence of cytotoxic T-lymphocyte (CTL) responses to influenza virus recognized in association with self HLA antigens for the presence of HTLV-III antibodies. Homosexual donors who were CTL responders retained their respective CTL profile for up to 2 years. Peripheral leucocytes from patients with AIDS generated no CTL activity to influenza virus but there was commonly CTL responses to HLA alloantigens. The selective loss of an HLA-restricted cytotoxic T-lymphocyte response without loss of HLA alloantigenic cytotoxic T-lymphocyte activity may be an important characteristic in the development of AIDS and may be used in therapeutic protocols at early stages of the disease. This mechanism may provide T-cell help by alloantigen-induced interleukin-2 production which may be of value in surveillance against opportunistic infection. However, it is also possible that elevated T-cell function results in increased immune destruction of HTLV-III-infected lymphocytes and would thus lead to a further decline of the immune system.G.W. Csonka
KW  - Acquired immune deficiency syndrome
KW  - HIV infections
KW  - homosexuality
KW  - human immunodeficiency viruses
KW  - immunology
KW  - influenza viruses
KW  - men
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthomyxoviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cytotoxic T lymphocyte response to influenza virus
KW  - HLA self-restricted cytotoxic T lymphocyte response
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Influenzavirus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026962&site=ehost-live&scope=site
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TY  - JOUR
T1  - Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus.
AU  - Folks, T.
AU  - Benn, S.
AU  - et al.
AU  - Rabson, A. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1985///
VL  - 82
IS  - 13
SP  - 4539
EP  - 4543
SN  - 0027-8424
AD  - Folks, T.: Office of the Scientific Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19852025793.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A cell line, originally isolated from a child with acute lymphocytic leukaemia, was cultured in the presence of 8-azaguanine to produce a clone hypoxanthine/aminopterin/thymine (HAT)-sensitive continuous cell line. These cultured T cells were sensitive to infection with HTLV-III virus which produced a cytopathic effect, infected cells dying over a period of 3-5 days which coincided with the peak of reverse transcriptase activity. Some preliminary studies, using restriction endonuclease analysis, showed that there were no changes on adaptation of HTLV-III to these cells, designated A3.01 cells.[See also abstract above.]R.N.P. Sutton
KW  - cell cultures
KW  - human immunodeficiency viruses
KW  - USA
KW  - man
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - A3.01 continuous line
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852025793&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes.
AU  - Hahn, B. H.
AU  - Gonda, M. A.
AU  - et al.
AU  - Shaw, G. M. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1985///
VL  - 82
IS  - 14
SP  - 4813
EP  - 4817
SN  - 0027-8424
AD  - Hahn, B. H.: Lab. of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19862026122.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - ... [The authors] compared the molecularly cloned genomes of two variant HTLV-III isolates by extensive restriction enzyme mapping and heteroduplex thermal melt analysis. Both viral isolates were found to be highly related to each other throughout their entire genomic complement, yet they differed markedly in their restriction enzyme maps. Electron microscopic heteroduplex analysis revealed several distinct regions of divergence located almost exclusively in the part of the genome that encodes the viral envelope gene. In vitro culture of one of these viruses over a period of 3 months did not result in any genomic changes as determined by restriction analysis of viral DNA. These results, as well as the recently published nucleotide sequences of other HTLV-III isolates, indicate that the most substantial variaton among HTLV-III isolates is located in the envelope. ...AS
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - human immunodeficiency viruses
KW  - USA
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - genomic diversity
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Isolation of infectious T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and from healthy carriers: a study of risk groups and tissue sources.
AU  - Salahuddin, S. Z.
AU  - Markham, P. D.
AU  - et al.
AU  - Popovic, M. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1985///
VL  - 82
IS  - 16
SP  - 5530
EP  - 5534
SN  - 0027-8424
AD  - Salahuddin, S. Z.: Lab. of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19862026123.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Since late 1982 the authors have isolated infectious virus from 47 AIDS patients (out of 93 attempted), 35 of 41 patients with "AIDS-related complex" and 19 of 67 clinically healthy donors at risk for AIDS. Virus was isolated mostly from peripheral blood lymphocytes but also from bone marrow, lymph nodes, brain tissue, cell-free plasma, and from cells associated with saliva, cerebrospinal fluid and semen. The risk groups included homosexuals, promiscuous heterosexuals, intravenous drug users, recipients of blood or blood products, and spouses and offspring of AIDS patients and others at risk for AIDS. "A high correlation was seen between persistent levels of serum antibody and the ability to isolate virus from patient or donor leukocytes. Immunologic and nucleic acid analysis demonstrated that the virus isolates were highly related, although substantial diversity was observed in the restriction enzyme cleavage patterns of those studied in detail. Biological analysis of cells from infected patients and donors as well as from normal peripheral blood mononuclear cells exposed to virus in vitro demonstrated that OKT4/Leu3a+ (helper/inducer) lymphocytes were preferentially infected and were subjected to a characteristic cytopathic effect."D.W. FitzSimons
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - human immunodeficiency viruses
KW  - USA
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus
KW  - United States of America
KW  - various tissues of risk groups
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026123&site=ehost-live&scope=site
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DB  - lhh
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TY  - JOUR
T1  - 3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
AU  - Mitsuya, H.
AU  - Weinhold, K. J.
AU  - et al.
AU  - Furman, P. A. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1985///
VL  - 82
IS  - 20
SP  - 7096
EP  - 7100
SN  - 0027-8424
AD  - Mitsuya, H.: The Clinical Oncology Program, National Cancer Institute, Bethesda, MA 20205, USA.
N1  - Accession Number: 19862027103.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Azidodeoxythymidine blocks expression of the p24 gag protein at 5-10 µmol/l and protects target T cells against the cytopathic effects of strains of HTLV-III that differ by about 20% in their env gene amino acid sequence. At ≥0.5 µmol/l it also blocks viral replication in normal human peripheral blood mononuclear cells exposed to HTLV-III, as measured by reverse transcriptase activity. Concentrations up to 50 µmol/l only slightly inhibit some immunological reactivities of normal T cells, and when given in high doses (85-150 mg/kg body weight) to rats and dogs for up to 4 weeks it caused little or no toxicity. The authors note that the compound is a competitive inhibitor of the reverse transcriptase of HTLV-III as the triphosphate but that the unphosphorylated parent does not inhibit the enzyme per se.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - Azidothymidine
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 
TY  - JOUR
T1  - Human T-cell growth factor (interleukin 2) and γ-interferon genes: expression in human T-lymphotropic virus type III- and type I-infected cells.
AU  - Arya, S. K.
AU  - Gallo, R. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1985///
VL  - 82
IS  - 24
SP  - 8691
EP  - 8695
SN  - 0027-8424
AD  - Arya, S. K.: Lab of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862027454.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors postulated that T-cell depletion in AIDS was due to impaired synthesis of T-cell growth factor (TCGF, interleukin-2) and that adult T-cell leukaemia was due to unregulated production of the latter. "The results reported here show that the transcription of the TCGF gene was not impaired in cultured HTLV-III-infected cells. Paradoxically, the TCGF gene in HTLV-I-infected cells was transcriptionally inactive. The reverse was the case for the γ-interferon gene-it was actively transcribed in HTLV-I-infected cells but not in the HTLV-III-infected and virus-producing H9 and H4 cell line. No evidence was obtained suggesting abnormal regulation of the TCGF or of the IFN-γ gene consequent to HTLV-III infection. It thus appears that in both HTLV-III and HTLV-I infection, growth control and immune regulatory mechanisms may bypass a modulatory role of TCGF or of IFN-γ."AS/D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - human immunodeficiency viruses
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Human T-cell lymphotropic virus
KW  - AIDS
KW  - gene induction
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human innunodeficiency virus
KW  - interleukin 2 and gamma-interferon genes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Importance of western blot analysis in predicting infectivity of anti-HTLV-III/LAV positive blood.
AU  - Esteban, J. I.
AU  - Shih, J. W. K.
AU  - Tai, C. C.
AU  - Bodner, A. J.
AU  - Kay, J. W. D.
AU  - Alter, H. J.
JO  - Lancet
JF  - Lancet
Y1  - 1985///
VL  - ii
SP  - 1083
EP  - 1086
AD  - Esteban, J. I.: Dept of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19852025748.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Stored donor and recipient sera from prospective studies of post-transfusion hepatitis were analysed for the presence of human T-cell lymphotropic virus type-III/lymphadenopathy associated virus (HTLV-III/LAV) antibodies as determined by enzyme-linked immunosorbent assays (ELISA). Of 3961 donors samples given to 461 patients, only 2 (0.05%) contained specific HTLV-III/LAV antibodies as determined by an avidin-biotin-enhanced western blot technique. Anti-HTLV-III/LAV was measured before and 3 and 6 months after transfusion in 295 recipients of anti-HTLV-III-negative blood, 7 recipients of ELISA-positive blood which was western blot negative, and 2 recipients of ELISA-positive blood confirmed as specific by western blot. Only the last 2 recipients became infected with HTLV-III/LAV, as assessed by antibody seroconversion (P &lt;0.0001). Seroconverion occurred early (6 and 8 weeks after transfusion) and was characterised first by antibody to p24 and later by antibody to p41. AIDS has not developed in either patient, but one has a T4/T8 ratio of 0.4 and impaired mitogen responses; the second patient has no evidence of immune dysfunction 4 years after exposure. This study confirms that HTLV-III/LAV infection can be transmitted by blood transfusion and supports the advisability of anti-HTLV-III/LAV testing of all blood donors. It also confirms the validity of western blot testing for HTLV-III/LAV specificity and suggests that ELISA-positive, western-blot-negative blood may not be infectious.AS
KW  - human immunodeficiency viruses
KW  - infections
KW  - prevention
KW  - transfusion
KW  - transmission
KW  - viral diseases
KW  - western blotting
KW  - USA
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Techniques and Methodology (ZZ900) 
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ER  - 

TY  - GEN
T1  - HTLV-I and HTLV-III antibodies and tropical spastic paraparesis.
AU  - Rodgers-Johnson, P.
AU  - Gajdusek, D. C.
AU  - Morgan, O. St C.
AU  - Zaninovic, V.
AU  - Sarin, P. S.
AU  - Graham, D. S.
T2  - Lancet
JO  - Lancet
JF  - Lancet
Y1  - 1985///
VL  - ii
SP  - 1247
EP  - 1248
AD  - Rodgers-Johnson, P.: Lab. of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19862029024.  Publication Type: Correspondence.  Language: English.  Subject Subsets: Tropical Diseases
N2  - Antibodies to HTLV-I and to HTLV-III were estimated in sera and cerebrospinal fluid (CSF) from patients with tropical spastic paraparesis in Jamaica and in Colombia. Few possessed HTLV-III antibodies but the proportion with HTLV-I antibodies ranged from 55% in Jamaican CSF to 100% in Colombian sera. These results confirm similar findings in patients with the same condition in Martinique and suggest that further epidemiological and other studies are indicated.[These reports of the association of retrovirus infection with neurological disease add a further dimension to the possible role of this group of viruses.]R.N.P. Sutton
KW  - acquired immune deficiency syndrome
KW  - HTLV infections
KW  - patients
KW  - serological surveys
KW  - tropical spastic paraparesis
KW  - Caribbean
KW  - Colombia
KW  - Jamaica
KW  - South America
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - Andean Group
KW  - Latin America
KW  - South America
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - seroepidemiology
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cryptococcosis in the acquired immunodeficiency syndrome.
AU  - Kovacs, J. A.
AU  - Kovacs, A. A.
AU  - et al.
AU  - Polis, M. (
AU  - Gelmann, E. P.\Lane, H. C.\Longfield, R.\Overturf, G.\Macher, A. M.\Fauci, A. S.\Porrillo, J. E.\Bennett, J. E.\Masur, H.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1985///
VL  - 103
IS  - 4
SP  - 533
EP  - 538
SN  - 0003-4819
AD  - Kovacs, J. A.: Critical Care Medical Dept, Clinical Center, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862026274.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - Clinical aspects of disease in patients with AIDS and Cryptococcus neoformans infection from 6 medical centres in the USA are reviewed retrospectively. In 7 cryptococcosis was the initial feature and in a further 7 (who presented with Kaposi's sarcoma) the earliest opportunistic infection; 25 patients had at least one other opportunistic process at some time during their clinical course. The most common clinical manifestation of cryptococcal infection was meningitis plus encephalitis (in 18); culture (100%), cryptococcal antigen (100%) and Indian ink test (82%) on cerebrospinal fluid were of great value in diagnosis in those tested. In those without meningitis blood cultures and serum cryptococcal antigen were sometimes positive. After a course of treatment (amphotericin B plus flucytosine, or amphotericin B alone) only 10 of 24 had no evidence of continuing infection and of these 6 had clinical relapses, leading to death in at least 2 of them. Orthodox management of cryptococcosis is thus extremely unsatisfactory in AIDS sufferers; this might be improved by earlier diagnosis or long-term therapy. Overall, cryptococcosis seemed to play a major part in 9 deaths.(At the National Institutes of Health C. neoformans ranks fourth, after cytomegalovirus, Pneumocystis carinii and Mycobacterium avium-intracellulare, as a life-threatening infection in AIDS patients.)G.C. Cook&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The clinical course and response to therapy of 27 patients with Cryptococcus neoformans and acquired immune deficiency syndrome (AIDS) were reviewed. Cryptococcosis was the initial manifestation of the syndrome in 7 patients and the initial opportunistic infection in an additional 7. Meningitis was the commonest clinical feature (18 patients). Blood cultures and serum cryptococcal antigen were frequently positive. In patients with meningitis, leukocyte count, protein level and glucose level in cerebrospinal fluid were frequently normal; cerebrospinal fluid India ink test (82%), culture (100%) and cryptococcal antigen (100%) were usually positive. Of 24 patients treated with amphotericin B alone or in combination with flucytosine [5-fluorocytosine], only 10 had no evidence of infection after completion of therapy; 6 of these 10 had relapses shown by clinical findings or at autopsy.
KW  - acquired immune deficiency syndrome
KW  - cryptococcosis
KW  - hosts
KW  - infection
KW  - predisposition
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - european blastomycosis
KW  - fungus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026274&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genomic diversity of human T-lymphotropic virus type III (HTLV-III).
AU  - Wong-Staal, F.
AU  - Shaw, G. M.
AU  - et al.
AU  - Hahn, B. H. (
JO  - Science, USA
JF  - Science, USA
Y1  - 1985///
VL  - 229
IS  - Aug. 23
SP  - 759
EP  - 762
AD  - Wong-Staal, F.: Lab. of Tumour Cell Biology, National Cancer Institute, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19852025795.  Publication Type: Journal Article.  Language: English.  Registry Number: 9007-49-2.  Subject Subsets: Public Health
N2  - Eighteen HTLV-III isolates were subjected to restriction endonuclease analysis. All were different and the number of restriction-site differences ranged from 1 to at least 16. There was no relationship to clinical features but isolates recovered at about the same time from patients in similar areas had close restriction patterns; isolates from Californian and Haitian patient differed considerably. In most patients only one predominant form of virus was identified, suggesting either selective pressures during cultivation in vitro or that some kind of interference may occur as these patients were probably subjected to repeated exposure to different viruses.[Further studies with HTLV-III clearly demonstrate that fresh problems are arising.]R.N.P. Sutton
KW  - DNA
KW  - human immunodeficiency viruses
KW  - nucleic acids
KW  - USA
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - deoxyribonucleic acid
KW  - genomic diversity
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852025795&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genomic heterogeneity of AIDS retroviral isolates from North America and Zaïre.
AU  - Benn, S.
AU  - Rutledge, R.
AU  - et al.
AU  - Folks, T. (
JO  - Science, USA
JF  - Science, USA
Y1  - 1985///
VL  - 230
SP  - 949
EP  - 951
AD  - Benn, S.: Lab. of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862027931.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health; Tropical Diseases
N2  - HTLV-III strains were recovered from patients in New York and Alabama, USA, and Zaïre (plus a prototype LAV strain). DNA was extracted and subjected to restriction endonuclease analysis, using 7 enzymes. Some sites of restriction were present in every strain and could be considered a signature of the AIDS virus. The one French (LAV) and 8 North American isolates (including ARV-2) contained 20-24 of the 24 conserved restriction sites; by contrast, the 3 Zaïrean strains retained only 14 or 15 of these sites. The African isolates contained a greater number of distinctive restriction enzyme sites than the French or American ones, but the difference was not as striking as the loss of conserved sites. The authors clearly demonstrate the heterogeneity of AIDS retrovirus genomes.R.N.P. Sutton
KW  - acquired immune deficiency syndrome
KW  - human immunodeficiency viruses
KW  - strains
KW  - Africa
KW  - Congo Democratic Republic
KW  - North America
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - American and Zairean
KW  - genomic heterogeneity
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Zaire
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HTLV-III infection among health care workers: association with needle-stick injuries.
AU  - Weiss, S. H.
AU  - Saxinger, C.
AU  - et al.
AU  - Rechtman, D. (
AU  - Grouse, L. D.\Stricof, R. L.\Morse, D. L.
JO  - Journal of the American Medical Association
JF  - Journal of the American Medical Association
Y1  - 1985///
VL  - 254
IS  - 15
SP  - 2089
EP  - 2093
AD  - Weiss, S. H.: Environmental Epidemiology Branch, National Cancer Institute, Landow Bldg, Rm 3C29, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862029093.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Some 361 health-care personnel at medical centres in several metropolitan areas of the USA volunteered for HTLV-III testing and provided background information about risk factors. Sera were tested by ELISA and borderline or positive samples were retested by Western blot. Six (26%) of 23 such personnel with recognized risk factors for AIDS were seropositive. Three health-care workers and a clinical laboratory worker, who did not belong to recognized AIDS risk groups, were seropositive, although one has not volunteered for further epidemiological investigation. Case reports of the other 3 are given. All reported possible parenteral exposure (to an AIDS patient or pooled platelets). In one, blood was not available before the needle-stick exposures but other evidence is consistent with occupational exposure. The second is ambiguous because her partner became seropositive but no serum samples for him soon after her exposure were available. The third case represents probable occupational transmission but awaits further investigation [and has subsequently been confirmed, see McGray et al. below. See also an editorial by L.D. Grouse, pp. 2130-2131.]D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - disease transmission
KW  - health care workers
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - needlestick injuries
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Health Services (UU350) 
KW  - Human Injuries (VV610) (Discontinued March 2000)
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TY  - JOUR
T1  - Heterosexually acquired HTLV-III/LAV disease (AIDS-related complex and AIDS): epidemiologic evidence for female-to-male transmission.
AU  - Redfield, R. R.
AU  - Markham, P. D.
AU  - Salahuddin, S. Z.
AU  - Wright, D. C.
AU  - Sarngadharan, M. G.
AU  - Gallo, R. C.
AU  - Echenberg, D. F.
JO  - Journal of the American Medical Association
JF  - Journal of the American Medical Association
Y1  - 1985///
VL  - 254
IS  - 15
SP  - 2094
EP  - 2096
AD  - Redfield, R. R.: National Cancer Institute, Laboratory of Tumor Cell Biology, Bldg 37, Rm 6A09, Bethesda, MD 20205, USA (Gallo).
N1  - Accession Number: 19862029094.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Fifteen of 41 patients with diseases associated with HTLV-III (10 men and 5 women) seen in Washington DC acquired their infections from spouses with AIDS or partners who were at risk for AIDS in 6 cases or from prostitutes (8 cases) or multiple sexual partners (1 case). The contacts with prostitutes were in the USA (New York City and Dallas), Korea and Germany. Receptive anal intercourse is shown not to be a requirement for infection in this group.In an editorial D.F. Echenberg (pp. 2129-2130) proposes that all AIDS patients be interviewed to obtain their heterosexual contacts who should be traced, tested and counselled. He argues that educational campaigns will be more difficult among heterosexual groups than among homosexual ones.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - heterosexual transmission
KW  - heterosexuality
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - transmission
KW  - North America
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - heterosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Variation in human T lymphotropic virus III (HTLV-III) antibodies in homosexual men: decline before onset of illness related to acquired immune deficiency syndrome (AIDS).
AU  - Biggar, R. J.
AU  - Melbye, M.
AU  - et al.
AU  - Ebbesen, P. (
JO  - British Medical Journal
JF  - British Medical Journal
Y1  - 1985///
VL  - 291
IS  - Oct. 12
SP  - 997
EP  - 998
AD  - Biggar, R. J.: Environmental Epidemiology Branch and Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda 20205, Maryland, USA.
N1  - Accession Number: 19852025971.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Western blot analysis was used to document the development and changes in human T lymphotropic virus III (HTLV-III) antibody among [250] Danish homosexual men followed longitudinally over three years. Reactivity against p15, p24, and p55 appeared earliest. After seroconversion the antibody concentration fluctuated, but in one instance a steady decline in banding intensity was seen during the 18 months before onset of the acquired immune deficiency syndrome (AIDS) and throughout the remaining eight months of his life.AS
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - homosexuality
KW  - human immunodeficiency viruses
KW  - infections
KW  - men
KW  - viral diseases
KW  - Denmark
KW  - man
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - AIDS
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - reductions
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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TY  - GEN
T1  - Effects of a novel compound (AL 721) on HTLV-III infectivity in vitro.
AU  - Sarin, P. S.
AU  - Gallo, R. C.
AU  - Scheer, D. I.
AU  - Crews, F.
AU  - Lippa, A. S.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1985///
VL  - 313
IS  - 20
SP  - 1289
EP  - 1290
SN  - 0028-4793
AD  - Sarin, P. S.: National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862026531.  Publication Type: Correspondence.  Language: English.  Subject Subsets: Public Health
N2  - The authors report the results of a preliminary investigation in vitro of a novel compound that appears to restrict the infectivity of HTLV-III for human peripheral blood lymphocytes and helper T cells. The compound (AL 721) is a mixture (7:2:1) of neutral glycerides, phosphatidylcholine and phosphatidylethanolamine; it has previously been shown to extract cholesterol from cellular membranes in vitro and to restore lymphocyte proliferation in healthy, elderly volunteers without adverse effects.AL 721 does not directly inhibit reverse transcriptase and is thought to act by its effect on the retrovirus envelope or on the host-cell membrane.David Greenwood
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - AL 721
KW  - AL 721 antiviral agent
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - GEN
T1  - Inactivation of human T-cell lymphotropic retrovirus (HTLV-III) by LDtm.
AU  - Sarin, P. S.
AU  - Scheer, D. I.
AU  - Kross, R. D.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1985///
VL  - 313
IS  - 22
SP  - 1416
EP  - 1416
SN  - 0028-4793
AD  - Sarin, P. S.: National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862027692.  Publication Type: Correspondence.  Language: English.  Subject Subsets: Public Health
N2  - The authors produce evidence based on inhibition of replication in H9 cells to show that the laboratory disinfectant LDtm (Alcide, Norwalk, Connecticut, USA) is an effective inactivator of HTLV-III/LAV. The product releases chlorous acid and subsequently chlorine dioxide. The results based on the average of 4 experiments indicate complete inactivation of the virus when used at a dilution of 1 in 200 of its standard-use dilution. The authors suggest the product would be useful in hospitals and clinical laboratories.A.E. Wright
KW  - acquired immune deficiency syndrome
KW  - Disinfectants
KW  - human immunodeficiency viruses
KW  - inactivation
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - HTLV-III inactivation
KW  - human immunodeficiency virus
KW  - laboratory disinfectant
KW  - LDtm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex.
AU  - Resnick, L.
AU  - DiMarzo Veronese, F.
AU  - et al.
AU  - Schüpbach, J. (
AU  - Gallo, R. C.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1985///
VL  - 313
IS  - 24
SP  - 1498
EP  - 1504
SN  - 0028-4793
AD  - Resnick, L.: (R.C. Gallo) Bldg 37, Rm 6A09, National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862029641.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors examined the cerebrospinal fluid (CSF) and serum of patients with AIDS-related neurological syndromes for the presence of specific anti-HTLV-III/LAV antibodies by fixed-cell immunofluorescence, ELISA, immunoblot and radioimmunoprecipitation. 22 of 23 had specific antibodies in the CSF and unique oligoclonal bands were demonstrated. Furthermore, the percentage of HTLV-III/LAV-specific IgG in CSF was higher than in serum and the rate of IgG synthesis within the blood-brain barrier was elevated. [See abstracts above and below.]I.V.D. Weller
KW  - acquired immune deficiency syndrome
KW  - brain
KW  - clinical aspects
KW  - human immunodeficiency viruses
KW  - nervous system
KW  - patients
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cerebrum
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The AIDS problem in Africa.
AU  - Biggar, R. J.
JO  - Lancet
JF  - Lancet
Y1  - 1986///
VL  - i
SP  - 79
EP  - 83
AD  - Biggar, R. J.: International AIDS Epidemiology, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MA 20205, USA.
N1  - Accession Number: 19862027259.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Subject Subsets: Public Health; Tropical Diseases
N2  - A valuable review of existing knowledge and of the relevance of studies of AIDS in Africa to the disease elsewhere.
KW  - acquired immune deficiency syndrome
KW  - epidemiology
KW  - Africa
KW  - AIDS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Treponematoses and tropical spastic paraparesis.
AU  - Rodgers-Johnson, P.
AU  - Morgan, O. St. C.
AU  - et al.
AU  - Zaninovic, V. (
JO  - Lancet
JF  - Lancet
Y1  - 1986///
VL  - i
IS  - Apr. 5
SP  - 809
EP  - 809
AD  - Rodgers-Johnson, P.: Laboratory of Central Nervous System Studies, NINCDS, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862028674.  Publication Type: Journal Article.  Subject Subsets: Tropical Diseases
N2  - It is unfortunate that the authors of this letter decided to dispense with a control population when presenting data of antibodies against treponemes and borrelia in sera taken from cases of tropical spastic paraparesis seen in Jamaica and Colombia. A high incidence (11 of 24 Jamaican samples) of positive syphilitic tests in this condition has been previously recorded. The presence of Lyme antibodies detected by an IFA-ABS test in 6 of 24 Jamaican samples is not surprising as the significant titre was taken as 1 in 5 which in my experience would include a large segment of the normal population. The most surprising finding is the presence of HTLV-I antibodies in serum and cerebrospinal fluid detected by enzyme-linked immunosorbent assay in both groups of patients. The relationship between these antibody findings and the clinical disease remains speculative.D.J.M. Wright
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - HTLV infections
KW  - Lyme disease
KW  - patients
KW  - treponematosis
KW  - Tropical spastic paraparesis
KW  - Caribbean
KW  - Colombia
KW  - Jamaica
KW  - South America
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - Andean Group
KW  - Latin America
KW  - South America
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - AIDS HTLV-I serology
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - lyme borreliosis
KW  - treponemes and HTLV-I
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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TY  - JOUR
T1  - Long-term use of oral contraceptives and risk of invasive cervical cancer.
AU  - Brinton, L. A.
AU  - Huggins, G. R.
AU  - et al.
AU  - Lehman, H. F. (
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1986///
VL  - 38
IS  - 3
SP  - 339
EP  - 344
SN  - 0020-7136
AD  - Brinton, L. A.: Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Rm. 3C06, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862034114.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A study in 5 regions of the USA revealed, after control for interval since last Pap smear, an increased risk of invasive cervical cancer among long-term users of oral contraceptives.D.W. FitzSimons
KW  - cervix
KW  - contraceptives
KW  - Family planning
KW  - female genitalia
KW  - genitalia
KW  - mouth
KW  - neoplasms
KW  - oral contraceptives
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - female genital system
KW  - long-term use
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Fertility (UU250) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Mosses, liverworts, and hornworts screened for antitumor agents.
AU  - Spjut, R. W.
AU  - Suffness, M.
AU  - Cragg, G. M.
AU  - Norris, D. H.
JO  - Economic Botany
JF  - Economic Botany
Y1  - 1986///
VL  - 40
IS  - 3
SP  - 310
EP  - 338
SN  - 0013-0001
AD  - Spjut, R. W.: Natural Products Branch, National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19860340790.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Horticultural Science; Weeds
N2  - The methods used by the National Cancer Institute in collecting and prescreening bryophytes are reviewed, and screening data are discussed for species that showed significant biological activity in bioassays. Results are summarized in a table listing species alphabetically by family and by genus. Extracts of 75 species were cytotoxic and those of 43 (mostly different) species showed antitumour activity.
KW  - composition
KW  - medicinal plants
KW  - Medicinal properties
KW  - utilization
KW  - Weeds
KW  - USA
KW  - Bryophyta
KW  - plants
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - United States of America
KW  - Plant Composition (FF040) 
KW  - Weeds and Noxious Plants (FF500) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.
AU  - Starcich, B. R.
AU  - Hahn, B. H.
AU  - et al.
AU  - Shaw, G. M. (
JO  - Cell
JF  - Cell
Y1  - 1986///
VL  - 45
IS  - 5
SP  - 637
EP  - 648
AD  - Starcich, B. R.: Laboratory of Tumor Cell Biology, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205, USA.
N1  - Accession Number: 19862031999.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors analysed the nucleotide and deduced amino acid sequences of the complete envelope genes and part of the gag and pol genes for HTLV-III isolates from 2 Haitian patients with AIDS. Comparison with published sequences for 3 other isolates revealed extensive variation throughout the genome, in particular in the envelope gene. Interspersed within the variable regions were highly conserved areas. Hypervariable regions appear to represent potential antigenic sites. Types of mutation differed in the env and gag genes. The rate of genetic change for the env gene is at least 10-3 nucleotide substitutions per site per year, similar to that of influenza A virus.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - analysis
KW  - Evolution
KW  - genomes
KW  - human immunodeficiency viruses
KW  - Structure
KW  - Virology
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - envelope genes
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization.
AU  - Harper, M. E.
AU  - Marselle, L. M.
AU  - Gallo, R. C.
AU  - Wong-Staal, F.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1986///
VL  - 83
IS  - 3
SP  - 772
EP  - 776
SN  - 0027-8424
AD  - Harper, M. E.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862029162.  Publication Type: Journal Article.  Subject Subsets: Public Health
N2  - The authors used in situ hybridization to examine directly primary lymph node and peripheral blood from patients with AIDS and AIDS-related complex for the presence of HTLV-III RNA. Mononuclear cell preparations were hybridized with a 35S-labelled HTLV-III-specific RNA probe and exposed to autoradiographic emulsion for 2 days. HTLV-III-infected cells expressing viral RNA were detected in 6 of 7 lymph node and 7 of 14 peripheral blood samples studied, but in all samples examined labelled cells were observed at very low frequency (&lt;0.01% of total mononuclear cells). Viral RNA was expressed at relatively low abundance (20-300 copies per cell). The morphology of infected cells was consistent with that of lymphocytes. "These results demonstrate that HTLV-III expression in lymph node and peripheral blood is very low in vivo. Furthermore, the lymph node hyperplasia observed in HTLV-III-associated lymphadenopathy is not directly due to proliferation of HTLV-III-infected lymphocytes."D.W. FitzSimons
KW  - Acquired immune deficiency syndrome
KW  - detection
KW  - human immunodeficiency viruses
KW  - in situ hybridization
KW  - pathology
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - lymphocyte detection
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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TY  - JOUR
T1  - Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides.
AU  - Mitsuya, H.
AU  - Broder, S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1986///
VL  - 83
IS  - 6
SP  - 1911
EP  - 1915
SN  - 0027-8424
AD  - Mitsuya, H.: Clinical Oncology Program, Building 10, Room 6B15, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862030690.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors investigated the activity of 9 purine and pyrimidine nucleoside analogues using HTLV-IIIB in an OKT4+ T-cell clone. Five 2′,3′-dideoxy compounds protected the T-cells against the cytopathic effect of the virus at 0.5-10 µmol/l (although the thymidine derivative was less active). These concentrations were 10-20 times lower than those that inhibited growth of cells in the absence of virus. The adenosine, guanosine, inosine and cytidine analogues all inhibited expression of the p24 gag protein at 10 µmol/l; the thymidine compound needed higher concentrations and allowed a resumption of viral replication after 10 days. Taking adenosine, the authors then investigated 5 derivatives that varied in the sugar group; only the 2′,3′-dideoxy compound completely protected the target cells against lysis by the virus and even the 2′,3′,5′-trideoxy compound failed to inhibit the cytopathic effect (presumably because of its inability to undergo phosphorylation). These 2′,3′-dideoxy compounds left the in vitro immune reactivity of normal T cells basically intact. Their mechanism of action is not known.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - Antiviral agents
KW  - dideoxynucleosides
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Three novel genes of human T-lymphotropic virus type III: immune reactivity of their products with sera from acquired immune deficiency syndrome patients.
AU  - Arya, S. K.
AU  - Gallo, R. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1986///
VL  - 83
IS  - 7
SP  - 2209
EP  - 2213
SN  - 0027-8424
AD  - Arya, S. K.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862031662.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The open reading frames sor, tat and 3′ orf were characterized. The genes synthesize polypeptides with apparent mobilities of Mr 23-24 000, 14-15 000 and 26-28 000, respectively all of which are immunogenic in vivo. Sera from AIDS and ARC patients immune precipitated the 3 gene products, particularly that of the 3′ orf gene. Some normal human sera reacted weakly with the sor gene product.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - Genetics
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - open reading frames
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - ORFs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - JC papovavirus large tumor (T)-antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non-AIDS patients with progressive multifocal leukoencephalopathy.
AU  - Stoner, G. L.
AU  - Ryschkewitsch, C. F.
AU  - Walker, D. L.
AU  - Webster, H. de F.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1986///
VL  - 83
IS  - 7
SP  - 2271
EP  - 2275
SN  - 0027-8424
AD  - Stoner, G. L.: Laboratory of Experimental Neuropathology, National Institute of Neurological and Communicative Disorders and Stroke, Building 9, Room 1E-127, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862031664.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Progressive multifocal leukoencephalopathy (PML) is a JC papovavirus infection of the central nervous system in immunocompromised patients. It is well established that demyelination in PML is caused by JC virus infection of oligodendroglia, but whether the nonstructural regulatory protein, large tumor (T) antigen, is detectable in infected human tissue was not known. Using a modification of the peroxidase-antiperoxidase technique, [the authors] found T antigen expressed in the nuclei of cells in virus-infected sites in five cases of PML studied, including two with acquired immune deficiency syndrome (AIDS). PML occurs in AIDS at a much higher frequency than in other immunosuppressive disorders, and PML in AIDS may represent a more severe form of JC virus infection of the central nervous system.AS
KW  - acquired immune deficiency syndrome
KW  - antigens
KW  - patients
KW  - progressive multifocal leukoencephalopathy
KW  - JC polyomavirus
KW  - Polyomavirus
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - AIDS
KW  - antigenicity
KW  - brain tissue
KW  - immunogens
KW  - JC polyomaviruses
KW  - JC virus
KW  - leukoencephalopathy
KW  - T
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I.
AU  - Matsushita, S.
AU  - Robert-Guroff, M.
AU  - Trepel, J.
AU  - Cossman, J.
AU  - Mitsuya, H.
AU  - Broder, S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1986///
VL  - 83
IS  - 8
SP  - 2672
EP  - 2676
SN  - 0027-8424
AD  - Matsushita, S.: Clinical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862031235.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors report the production of monoclonal antibody to an envelope glycoprotein of HTLV-I by B cells removed from the lymph node of a patient with adult T-cell leukaemia, transformed by Epstein-Barr virus and cloned by limiting dilution. The clones obtained were expanded and screened for anti-HTLV-I activity to enable an anti-HTLV-I env monoclonal antibody producing clone (designated 0.5 α) to be identified.[The production of immune monoclonal anti-HTLV-I env has proved difficult and for this and other reasons this work is notable. It also suggests a strategy for preparing human monoclonal antibodies that may have wider diagnostic and therapeutic applications.]P. Mortimer
KW  - acquired immune deficiency syndrome
KW  - glycoproteins
KW  - monoclonal antibodies
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - envelope
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Prospective evaluation of a monoclonal antibody in diagnosis of Pneumocystis carinii pneumonia.
AU  - Kovacs, J. A.
AU  - Gill, V.
AU  - Swan, J. C.
JO  - Lancet
JF  - Lancet
Y1  - 1986///
VL  - ii
IS  - July 5
SP  - 1
EP  - 3
AD  - Kovacs, J. A.: Depts of Critical Care Medicine and Microbiology, Clinical Center, National Institutes of Health, Bethesda, MA, USA.
N1  - Accession Number: 19862031255.  Publication Type: Journal Article.  Subject Subsets: Public Health
N2  - The authors used a mouse monoclonal antibody 2G2 directed against human Pneumocystis carinii in an indirect immunofluorescent assay to evaluate its diagnostic potential in clinical specimens. Of 25 bronchoscopy specimens obtained from AIDS patients over a 3-month period, 14 were positive for P. carinii by toluidine-blue-O stain. 13 of these were positive by immunofluorescence, with more than one clump of organisms being seen usually within the first minute. In the one false-negative case the organism was seen only rarely by staining and the specimen had been taken from a patient after 5 weeks of treatment for P. carinii pneumonia. None of the 11 stain-negative specimens was positive by immunofluorescence. Two impression smears of histologically negative open-lung biopsy specimens were also negative but both of two impression smears of histologically positive necropsy specimens were positive. "Immunofluorescence with monoclonal antibody 2G2 is a rapid, simple, and specific technique for detection of P. carinii in clinical specimens."D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - clinical aspects
KW  - Diagnosis
KW  - Immunodiagnosis
KW  - immunofluorescence
KW  - monoclonal antibodies
KW  - Opportunistic infections
KW  - Pneumocystis carinii pneumonia
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis
KW  - Pneumocystis carinii
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Pneumocystis
KW  - AIDS
KW  - clinical picture
KW  - fluorescent antibody technique
KW  - fungus
KW  - IFAT
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men.
AU  - Masur, H.
AU  - Lane, C.
AU  - et al.
AU  - Palestine, A. (
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1986///
VL  - 104
IS  - 1
SP  - 41
EP  - 44
SN  - 0003-4819
AD  - Masur, H.: Clinical Center, Building 10, Rm 10D-48, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862027835.  Publication Type: Journal Article.  Language: English.  Registry Number: 82410-32-0.  Subject Subsets: Public Health
N2  - This important paper reports a pilot study of the treatment of serious cytomegalovirus (CMV) infection in 8 patients with AIDS-7 with retinitis (1 with colitis as well) and 1 with pneumonitis alone. All 8 patients responded partially or completely but all relapsed within 30 days of cessation of treatment. Six surviving patients were then treated and 5 showed a clinical response to the second course. Maintenance regimens using 2.5 mg/kg for 3 to 5 doses a week had to be stopped because of leukopenia. This small series seems to establish, as appears generally acknowleged in the USA, that relapse of CMV infection in AIDS after treatment with dihydroxypropoxymethylguanine (DHPG) is almost inevitable unless maintenance regimens are used. [Too few patients, however, were tried on maintenance in this series to evaluate it as a reasonable therapeutic manoeuvre. (Syntex, a manufacturer of DHPG, reports that 5 doses per week are necessary for successful maintenance and not all patients become leukopenic on this dose.)]Charles Farthing
KW  - acquired immune deficiency syndrome
KW  - ganciclovir
KW  - infections
KW  - medical treatment
KW  - treatment
KW  - viral diseases
KW  - USA
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cytomegalovirus infection with AIDS
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
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TY  - GEN
T1  - Suramin and function of the adrenal cortex.
AU  - Stein, C. A.
AU  - Saville, W.
AU  - Yarchoan, R.
AU  - Broder, S.
AU  - Gelmann, E. P.
T2  - Annals of Internal Medicine
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1986///
VL  - 104
IS  - 2
SP  - 286
EP  - 287
SN  - 0003-4819
AD  - Stein, C. A.: National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862028935.  Publication Type: Correspondence.  Language: English.  Registry Number: 145-63-1.  Subject Subsets: Public Health
N2  - A patient with AIDS and Kaposi's sarcoma was treated with suramin, eventually at a maintenance dose of 1100 mg/m² (12.4 g) every 2 weeks whereupon he developed profound hyproadrenalism. (The authors do not exclude other possible causes such as overwhelming cytomegalovirus infection.)D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - Kaposi's sarcoma
KW  - medical treatment
KW  - suramin
KW  - treatment
KW  - AIDS
KW  - hypoadrenalism
KW  - Kaposi's sacoma
KW  - reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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TY  - JOUR
T1  - Long-term seropositivity for human T-lymphotropic virus type III in homosexual men without the acquired immunodeficiency syndrome: development of immunologic and clinical abnormalities.
AU  - Melbye, M.
AU  - Biggar, R. J.
AU  - et al.
AU  - Ebbesen, P. (
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1986///
VL  - 104
IS  - 4
SP  - 496
EP  - 500
SN  - 0003-4819
AD  - Melbye, M.: Environmental Epidemiology Branch, National Cancer Institute, Landow Building 3C19; Bethesda, MD 20892, USA.
N1  - Accession Number: 19862030056.  Publication Type: Journal Article.  Subject Subsets: Public Health
N2  - The natural history of HIV infection in 250 homosexual men in Denmark was studied by repeated serological testing since 1981. Serum samples were taken initially, then in 1982, 1983 and in 1984, when 134 individuals could be re-tested for HIV antibody and T-lymphocyte subsets studies. Initially 8.8% were HIV antibody positive. Seroconversion rate was 0.53% per month and by 1984 26.1% of those tested were HIV antibody positive. The presence of HIV antibody was associated with the number of sexual partners, increased frequency of receptive anal intercourse and use of nitrite inhalants. T-lymphocyte subsets were determined in 50 individuals, 19 of whom were HIV antibody positive. Sixteen of these 19 men had inverted T4/T8 ratios compared with 4 of the 31 seronegative men. Subjects who had been seropositive for the longest period of time had the lowest ratios. Clinically, lymphadenopathy was significantly associated with seropositivity both short- and long-term, whereas diarrhoea, oral thrush and herpes zoster were associated with long-term seropositivity only. Half the long-term seropositive men developed symptoms compared with 29% of the short-term and 16% of the seronegative group. Lymphadenopathy developed relatively early but persistent constitutional symptoms appeared later. It is as yet not known whether the patients with symptoms will develop AIDS or return to normal but the number of T-helper cells is considered to be a valuable predictor of the future development of AIDS.G.W. Csonka
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - clinical aspects
KW  - HIV infections
KW  - homosexuality
KW  - HTLV infections
KW  - human immunodeficiency viruses
KW  - Immunology
KW  - men
KW  - Serology
KW  - Denmark
KW  - Europe
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - AIDS
KW  - clinical picture
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - long-term seropositivity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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TY  - JOUR
T1  - Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV.
AU  - Folks, T.
AU  - Kelly, J.
AU  - et al.
AU  - Benn, S. (
JO  - Journal of Immunology
JF  - Journal of Immunology
Y1  - 1986///
VL  - 136
IS  - 11
SP  - 4049
EP  - 4053
AD  - Folks, T.: National Institutes of Health, Building 10, Room, 11B-13, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862033738.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Peripheral blood lymphocytes from all 10 healthy volunteers tested became infected and produced virus (as detected by reverse transcriptase activity) after pretreatment with phytohaemagglutinin (PHA) and incubation with HIV. The donors could be grouped into consistently high (3 individuals) or low producers of reverse transcriptase activity. The kinetics of virus production was similar for the 2 groups. Mitogen (PHA)-activated lymphocytes showed signs of infection earlier than untreated cells, and untreated cells did not show detectable reverse transcriptase activity. Reverse transcriptase activity correlated positively with the proportion of Leu 3+ cells in the lymphocyte sample. Addition of anti-human interferon-α to the cells did not affect virus production.The authors comment that the opportunistic infections in AIDS patients could result in activated T cells which would then accelerate the progress of the disease by allowing greater production of HIV.Carolyn A. Brown
KW  - acquired immune deficiency syndrome
KW  - human immunodeficiency viruses
KW  - Immunology
KW  - infections
KW  - lymphocytes
KW  - Opportunistic infections
KW  - Susceptibility
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Serological characterization of human T-cell leukemia (lymphotropic) virus, type I (HTLV-I) small envelope protein.
AU  - Newman, M. J.
AU  - Baker, I. T.
AU  - et al.
AU  - Reitz, M. S. (
AU  - Mann, D. L.
JO  - Virology
JF  - Virology
Y1  - 1986///
VL  - 150
IS  - 1
SP  - 106
EP  - 116
AD  - Newman, M. J.: (D.L. Mann) Lab. of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862030116.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - acquired immune deficiency syndrome
KW  - characterization
KW  - envelope proteins
KW  - Virology
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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ER  - 

TY  - JOUR
T1  - Enzyme immunoassay detection of immunoglobulin M and G antibodies to Cryptosporidium in immunocompetent and immunocompromised persons.
AU  - Ungar, B. L. P.
AU  - Soave, R.
AU  - Fayer, R.
AU  - Nash, T. E.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1986///
VL  - 153
IS  - 3
SP  - 570
EP  - 578
SN  - 0022-1899
AD  - Ungar, B. L. P.: Building 5, Rm 112, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
N1  - Accession Number: 19862031280.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 308067-57-4.  Subject Subsets: Protozoology; Public Health
N2  - The authors developed a sensitive, reproducible, enzyme-linked immunoassay (ELISA) for the detection of Cryptosporidium spp. IgG and IgM, using oocysts from experimentally infected calves as the antigen source. Sensitivity and specificity were 95% both in patients with and those without underlying AIDS. Thirteen of 15 immunocompetent people with cryptosporidiosis and all 26 AIDS sufferers with cryptosporidiosis were positive for IgG; 57 of 60 (18 with AIDS) who were not infected with Cryptosporidium were negative for IgG and the 3 who were positive might well have been exposed previously to infection (details given in text). All patients with AIDS produced IgG and some produced IgM; those without AIDS showed an early rise and fall in IgM and a later elevation of IgG. Nine (21%) of 44 Ecuadorian children with diarrhoea had a positive serological response for both IgM and IgG antibodies; serum samples from 106 people with other parasitic diseases (details given in text) gave a normal distribution for IgG antibody. [The authors consider that this will form a useful adjunct in the clinical diagnosis of cryptosporidiosis, in epidemiological screening, in a research setting and also in defining the humoral immune response to this infection.]G.C. Cook&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A sensitive and reproducible enzyme immunoassay for detection of serum IgG or IgM to Cryptosporidium was developed. For IgG, 13 of 15 patients with cryptosporidiosis and 26 of 26 patients with cryptosporidiosis and AIDS were positive, whereas 57 of 60 presumably uninfected individuals were negative. All 3 IgG-positive presumably uninfected individuals had been potentially exposed. Sensitivity and specificity of this assay were 95%. Patients without AIDS showed an early rise and fall of IgM and later elevation of IgG; some patients with AIDS produced IgM, and all produced IgG. Sera from 9 of 44 Ecuadorian children which diarrhoea were positive for both IgM and IgG antibodies; 106 sera from persons with other parasitic illnesses showed a normal distribution for IgG antibody. These ELISA data show that patients without and with AIDS have serum antibody response to Cryptosporidium and suggest that exposure to or infection with Cryptosporidium is common.
KW  - acquired immune deficiency syndrome
KW  - Cryptosporidiosis
KW  - Diagnosis
KW  - ELISA
KW  - Immunodiagnosis
KW  - Immunoglobulins
KW  - Immunology
KW  - Opportunistic infections
KW  - parasites
KW  - Serology
KW  - Ecuador
KW  - Cryptosporidium
KW  - man
KW  - protozoa
KW  - Cryptosporidiidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - AIDS
KW  - enzyme linked immunosorbent assay
KW  - gamma-globulins
KW  - immune globulins
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031280&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The slow, insidious natures of the HTLV's.
AU  - Marx, J. L.
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 231
SP  - 450
EP  - 451
AD  - Marx, J. L.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862028459.  Publication Type: Journal Article.  Subject Subsets: Public Health
N2  - Cells of the human T-cell line A3.O1 consist of 2 populations, one with the Leu-3 surface marker (Leu+) and the other without (Leu-). This report describes the persistence of HTLV-III in the Leu- cells and the subsequent induction of infectious virus by treatment with 5-iodo-2′-deoxyuridine.R.N.P. Sutton
KW  - acquired immune deficiency syndrome
KW  - chronic infections
KW  - culture techniques
KW  - human immunodeficiency viruses
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - Leu cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera.
AU  - Kan, N. C.
AU  - Franchini, G.
AU  - et al.
AU  - Wong-Staal, F. (
AU  - Papas, T. S.
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 231
IS  - Mar. 28
SP  - 1553
EP  - 1555
AD  - Kan, N. C.: (T.S. Papas) Lab. of Molecular Oncology, National Cancer Institute, National Institutes of Health, Frederick, MD 21701-1013, USA.
N1  - Accession Number: 19862029523.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Escherichia coli synthesized a protein of Mr 23 000 (p23, see above) from DNA containing 82% of the sor region of HTLV-III inserted into an expression vector. Sera from some (32-54%) AIDS and ARC patients and healthy subjects at risk of AIDS as well as some healthy donors (25%) reacted with the purified protein, believed to be the sor gene product.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - genomes
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - human immunodeficiency virus
KW  - sor gene product
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
AU  - Green, W. C.
AU  - Leonard, W. J.
AU  - et al.
AU  - Wano, Y. (
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 232
IS  - May 16
SP  - 877
EP  - 880
AD  - Green, W. C.: Metabolism Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862031963.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line resulted in the induction of both interleukin-2 receptor and interleukin-2 gene expression.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Genetics
KW  - Immunology
KW  - Deltaretrovirus
KW  - Human T-cell lymphotropic virus
KW  - HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE II
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - HTLV-BLV group
KW  - trans-activator gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031963&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neutralization of HTLV-III/LAV replication by antiserum to thymosin α1.
AU  - Sarin, P. S.
AU  - Sun, D. K.
AU  - Thornton, A. H.
AU  - Naylor, P. H.
AU  - Goldstein, A. L.
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 232
IS  - May 30
SP  - 1135
EP  - 1137
AD  - Sarin, P. S.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862031974.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - An antiserum prepared against thymosin α1, a hormone secreted by the thymus gland, effectively neutralized the AIDS-associated virus [HTLV-III/LAV(clone BH-10)] and blocked its replication in H9 cells. Reverse transcriptase activity and expression of the HTLV-III/LAV antigens p15 and p24 were inhibited by purified immunoglobulin G preparations of antisera to thymosin α1. The antiviral activity of the antiserum was found to be due to a region of homology between thymosin α1 and p17, a product of the gag gene of HTLV-III/LAV. Comparison of the primary sequences of thymosin α1 and the gag protein revealed a 44% to 50% homology in an 18-amino acid region, between positions 11 and 28 on thymosin α1 and 92 and 109 on the gag protein. The effectiveness of the thymosin α1 antiserum and of immunoglobulin G-enriched preparations in blocking replication of HTLV-III(BH-10) in H9 cells suggests a novel approach to the development of an AIDS vaccine. A vaccine directed against the gag protein might overcome the problem of genetic drift in the envelope region of the virus and be useful against all genetic variants of HTLV-III/LAV.AS
KW  - acquired immune deficiency syndrome
KW  - Control
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - neutralization
KW  - Replication
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - thymosin alpha1 antiserum
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes.
AU  - Waldmann, T. A.
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 232
IS  - May 9
SP  - 727
EP  - 732
AD  - Waldmann, T. A.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862031959.  Publication Type: Journal Article.  Language: English.  Registry Number: 102524-44-7, 85898-30-2.  Subject Subsets: Public Health
N2  - Antigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine. Failure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response. The receptor is composed of a 33 000-dalton (251-amino acid) peptide precursor that is post-translationally glycosylated into the mature 55 000-dalton form. In contrast to resting T cells, human T-cell lymphotropic virus I (HTLV-I)-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor.AS
KW  - acquired immune deficiency syndrome
KW  - Immunology
KW  - interleukin 2
KW  - medical treatment
KW  - receptors
KW  - treatment
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Replication of the B19 parvovirus in human bone marrow cell cultures.
AU  - Ozawa, K.
AU  - Kurtzman, G.
AU  - Young. N.
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 233
IS  - Aug. 22
SP  - 883
EP  - 886
AD  - Ozawa, K.: ACRF 7C108, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862034105.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - culture techniques
KW  - Parvoviridae
KW  - parvovirus B19
KW  - ssDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Parvovirus
KW  - Parvoviridae
KW  - human bone marrow cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of mononuclear phagocytes in HTLV-III/LAV infection.
AU  - Gartner, S.
AU  - Markovits, P.
AU  - Markovitz, D. M.
AU  - Kaplan, M. H.
AU  - Gallo, R. C.
AU  - Popovic, M.
JO  - Science, USA
JF  - Science, USA
Y1  - 1986///
VL  - 233
IS  - July 11
SP  - 215
EP  - 219
AD  - Gartner, S.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862032032.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - "Cells with properties characteristic of mononuclear phagocytes were evaluated for infectivity with five different isolates of the AIDS virus, HTLV-III/LAV. Mononuclear phagocytes cultured from brain and lung tissues of AIDS patients harbored the virus. In vitro-infected macrophages from the peripheral blood, bone marrow, or cord blood of healthy donors produced large quantities of virus. Virus production persisted for at least 40 days and was not dependent on host cell proliferation. Giant multinucleated cells were frequently observed in the macrophage cultures and numerous virus particles, often located within vacuole-like structures, were present in infected cells. The different virus isolates were compared for their ability to infect macrophages and T cells. Isolates from lung- and brain-derived macrophages had a significantly higher ability to infect macrophages than T cells. In contrast, the prototype HTLV-IIIB showed a 10 000-fold lower ability to infect macrophages than T cells and virus production was one-tenth that in macrophage cultures infected with other isolates, indicating that a particular variant of HTLV-III/LAV may have a preferential tropism for macrophages or T cells. These results suggest that mononuclear phagocytes may serve as primary targets for infection and agents for virus dissemination and that these virus-infected cells may play a role in the pathogenesis of the disease."[This report and an earlier one (see Lifson et al. above) emphasize the importance of the CD4 antigen in the infection of cells by HIV. Further, it is evident that the characteristic giant cell (syncytium) formation in some tissues in AIDS patients could arise from fusion of either T cells or macrophages.]S.B. Lucas
KW  - acquired immune deficiency syndrome
KW  - CD4 antigens
KW  - cells
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - infection
KW  - Macrophages
KW  - receptors
KW  - T lymphocytes
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - CD4
KW  - Cytopathology
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevalence of antibodies to HTLV-I, -II, and -III in intravenous drug abusers from an AIDS endemic region.
AU  - Robert-Guroff, M.
AU  - Weiss, S. H.
AU  - et al.
AU  - Giron, J. A. (
JO  - Journal of the American Medical Association
JF  - Journal of the American Medical Association
Y1  - 1986///
VL  - 255
IS  - 22
SP  - 3133
EP  - 3137
AD  - Robert-Guroff, M.: National Cancer Institute, National Institutes of Health, Bldg 37, Room 6A09, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862031920.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Antibody prevalences for human T-cell lymphotropic virus (HTLV) types I, II, and III were determined for 56 intravenous drug abusers from Queens, NY. While control serum samples lacked antibodies to all HTLV subgroups, seropositivity among drug users was 41% for HTLV-III, 18% for HTLV-II, and 9% for HTLV-I. Infection by HTLV-I and -II occurred independently of HTLV-III infection. Blacks had greater HTLV-III antibody prevalence than whites (54% vs 16%) and were more likely than whites to be seropositive for HTLV-I or -II (46% vs 11%). They exhibited a greater incidence than whites of double infection with HTLV-I or -II and HTLV-III (27% vs 0%), and 73% were seropositive for at least one of the viruses, compared with only 26% of the whites. The increased HTLV-I and -II infection seen in intravenous drug users suggests that once introduced into a population, these viruses may be transmitted by the same routes as HTLV-III. Transmission may have been restricted mainly to blacks in this study because of local drug use practices.[The subjects consisted of 2 groups: 25 drug users with various soft-tissue infections and 31 individuals undergoing drug detoxification without such infections. Samples of sera from the latter were collected in 1981 and 1982 and frozen until assay. Sera that were positive by ELISA were confirmed in competition assays or a modified Western blot for HTLV-III. With regard to the prevalence of HTLV-I infection the authors note a recent report of a cluster of cases of adult T-cell leukaemia in Brooklyn, N.Y., and point out the longer latency period for that disease than for AIDS and HTLV-III infections.]AS/D. W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - Drug abuse
KW  - drug users
KW  - HTLV infections
KW  - human immunodeficiency viruses
KW  - serological surveys
KW  - New York
KW  - North America
KW  - USA
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - human T-cell lymphotropic virus type II
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Human T-cell lymphotropic virus
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - drug abusers
KW  - drug use
KW  - HTLV-BLV group
KW  - HTLV-II and HTLV-III
KW  - human immunodeficiency virus
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - seroepidemiology
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The natural history of human T lymphotropic virus-III infection: the cause of AIDS.
AU  - Melbye, M.
JO  - British Medical Journal
JF  - British Medical Journal
Y1  - 1986///
VL  - 292
SP  - 5
EP  - 12
AD  - Melbye, M.: Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Landow Building 3C19, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862026964.  Publication Type: Journal Article.  Language: English.  Number of References: 134 ref. Subject Subsets: Public Health
KW  - HIV infections
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026964&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diagnosis of Creutzfeldt-Jakob disease by Western blot identification of marker protein in human brain tissue.
AU  - Brown, P.
AU  - Coker-Vann, M.
AU  - et al.
AU  - Pomeroy, K. (
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1986///
VL  - 314
IS  - 9
SP  - 547
EP  - 551
SN  - 0028-4793
AD  - Brown, P.: Bldg 36, Rm 5B05, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862029049.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The discovery of a fibrillary structure that contains a characteristic group of protease-resistant proteins in brain-tissue preparations from animals with scrapie and humans with Creutzfeldt-Jakob disease (CJD) has, as the authors state, "opened the door to an immunologic approach to the diagnosis of these diseases". Using the Western blot technique (details given), 75% of (4) kuru specimens were positive, as were 81% of those from 31 patients with CJD and 75% of brain specimens from 4 patients with the Gerstmann-Sträussler-Scheinker syndrome (which clinically may resemble CJD). Control specimens included brains from patients with a range of other conditions (Alzheimer's disease, AIDS encephalopathy, and other dementias) which clinically resembled CJD and where tissue had been submitted for a full range of investigation, including primate inoculation; all were negative.[This important paper indicates that Alzheimer's disease is, in all probability, not associated with infection by an agent similar to that responsible for CJD, a finding consistent with the unsuccessful attempts to transmit Alzheimer's disease to primates by inoculation.]R.N.P. Sutton
KW  - diagnosis
KW  - Immunodiagnosis
KW  - Kuru
KW  - AIDS encephalopathy pathology
KW  - Creuzfeld-Jakob disease
KW  - serological diagnosis
KW  - Western blot technique
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression of the HTLV-III envelope gene by a recombinant vaccinia virus.
AU  - Chakrabarti, S.
AU  - Robert-Guroff, M.
AU  - Wong-Staal, F.
AU  - Gallo, R. C.
AU  - Moss, B.
JO  - Nature, UK
JF  - Nature, UK
Y1  - 1986///
VL  - 320
IS  - Apr. 10
SP  - 535
EP  - 537
AD  - Chakrabarti, S.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862028917.  Publication Type: Journal Article.  Subject Subsets: Public Health
N2  - The env protein of HTLV-III can induce protective immunity in mice and is therefore of potential value in the construction of a vaccine against this virus. This report describes the preparation of an infectious recombinant vaccinia virus which contained this gene. Full details are given which show that this recombinant effectively synthesized the env protein without any other HTLV-III functions and that it was immunogenic in mice. (An addendum notes that 7 of 8 primates (Macaca fascicularis) immunized with the recombinant developed antibodies to the env protein.)[Clearly this is an important step forward in the control of AIDS.]R.N.P. Sutton
KW  - acquired immune deficiency syndrome
KW  - HTLV infections
KW  - human immunodeficiency viruses
KW  - immunization
KW  - recombination
KW  - mice
KW  - Vaccinia virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - AIDS
KW  - AIDS vaccine animal
KW  - genetic recombination
KW  - HTLV-III envelope gene
KW  - human immunodeficiency virus
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - immune sensitization
KW  - recombinant vaccinia virus with HTLV-III gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The trans-activator gene of HTLV-III is essential for virus replication.
AU  - Fisher, A. G.
AU  - Feinberg, M. B.
AU  - et al.
AU  - Josephs, S. F. (
JO  - Nature, UK
JF  - Nature, UK
Y1  - 1986///
VL  - 320
IS  - Mar. 27
SP  - 367
EP  - 371
AD  - Fisher, A. G.: Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD 20205, USA.
N1  - Accession Number: 19862028719.  Publication Type: Journal Article.  Subject Subsets: Public Health
N2  - Trans-activator genes have been found in human and animal retroviruses; these specifically augment expression of viral genes. Structural studies of HTLV-III have identified a trans-activated gene (tat-III) in addition to 5 previously known genes (gag, pol, sor, env and 3′orf). In this report derivatives of an HTLV-III clone in which tat-III had been deleted failed to produce the usual levels of virus when transfected into T-cell cultures. This observation that the tat-III gene is critical for HTLV-III replication suggests that the development of inhibitors that could specifically block the activity of these trans-acting factors may provide a new approach to the treatment of AIDS patients.[Further complex analysis of the HTLV-III genome may lead to effective therapy.]R.N.P. Sutton
KW  - acquired immune deficiency syndrome
KW  - genes
KW  - Genetics
KW  - human immunodeficiency viruses
KW  - replication
KW  - transactivation
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - AIDS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - First isolation of HTLV-III.
AU  - Gallo, R. C.
AU  - Sarin, P. S.
AU  - Kramarsky, B.
AU  - Salahuddin, Z.
AU  - Markham, P.
AU  - Popovic, M.
T2  - Nature, UK
JO  - Nature, UK
JF  - Nature, UK
Y1  - 1986///
VL  - 321
IS  - May 8
SP  - 119
EP  - 119
AD  - Gallo, R. C.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19862030709.  Publication Type: Correspondence.  Language: English.  Subject Subsets: Public Health
N2  - The history of the early studies on transmission of HTLV-III/LAV is explained and the chronology of isolations of the virus from 10 patients with AIDS or ARC (including 3 French patients) from December 1982 to April 1984 is summarized. [This strengthens Gallo's argument for prior discovery, an important issue in view of the patent rights (see p. 102).]D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - history
KW  - HTLV infections
KW  - human immunodeficiency viruses
KW  - transmission
KW  - France
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - APEC countries
KW  - North America
KW  - America
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - History and Biography (BB500) 
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ER  - 

TY  - JOUR
T1  - Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine.
AU  - Good, M. F.
AU  - Berzofsky, J. A.
AU  - Maloy, W. L.
AU  - Hayashi, Y.
AU  - Fujii, N.
AU  - Hockmeyer, W. T.
AU  - Miller, L. H.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1986///
VL  - l64
IS  - 2
SP  - 655
EP  - 660
SN  - 0022-1007
AD  - Good, M. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19860199422.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Animal Breeding; Protozoology
N2  - H-2-congenic strains of mice were immunized with a Plasmodium falciparum sporozoite vaccine, or with different segments of the vaccine molecule. Specific IgG production or lymph node cell proliferation in response to different antigens was then determined. Only 4 of 7 strains (representing 3 of 8 possible MHC class-II restriction molecules) responded to the vaccine. Of the restriction molecules, only one (I-Ab) was associated with a response to Plasmodium-encoded T epitope, while the other 2 molecules (EαdEβd and EαkEβs) were associated with a T-cell response to a non-malarial epitope(s) carboxyterminal to the Plasmodium sequence, and encoded by a tetracycline resistance gene, read out of frame. The immune response to the T-cell epitopes was under Ir gene control, and mapped to the I-A and I-G regions of the H-2 complex.
KW  - Genes
KW  - genetics
KW  - histocompatibility
KW  - hosts
KW  - immune response
KW  - immunization
KW  - Immunogenetics
KW  - immunology
KW  - Laboratory animals
KW  - molecular genetics
KW  - parasites
KW  - mice
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Rodents
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - biochemical genetics
KW  - H-2 complex
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - Plasmodium falciparum vaccine
KW  - sporozoite vaccine
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antigenic variation and antigenic diversity in malaria.
AU  - Howard, R. J.
JO  - Contributions to Microbiology and Immunology
JF  - Contributions to Microbiology and Immunology
Y1  - 1987///
VL  - 8
SP  - 176
EP  - 218
AD  - Howard, R. J.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861695.  Publication Type: Journal Article.  Language: English.  Number of References: 101 ref. Subject Subsets: Protozoology
N2  - Recent studies on antigenic diversity on infected erythrocytes (Plasmodium knowlesi variant or SICA antigen, P. falciparum, P. chabaudi), and merozoites (P. knowlesi merozoite surface antigen, antigenic diversity of the major surface glycoprotein on merozoites) are reviewed. Other aspects of phenotypic diversity, and genetic and phenotypic lability in Plasmodium are also briefly considered.
KW  - antigens
KW  - Human diseases
KW  - parasites
KW  - variation
KW  - Apicomplexa
KW  - Plasmodium
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - antigenicity
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mechanisms of immune evasion in schistosomiasis.
AU  - Pearce, E. J.
AU  - Sher, A.
JO  - Contributions to Microbiology and Immunology
JF  - Contributions to Microbiology and Immunology
Y1  - 1987///
VL  - 8
SP  - 219
EP  - 232
AD  - Pearce, E. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861696.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref. Subject Subsets: Helminthology
N2  - Mechanisms by which older schistosome larvae (&gt;24 h) and adults evade the immune system are discussed with regard to low surface antigenicity (disguise, host molecule mimicry, surface antigen sequestration and shedding), the role of reduced surface antigenicity as a defence against immune attack, the nature of intrinsic mechanisms of immune evasion, other evasion mechanisms and the consequences of immune evasion in relation to vaccine development.
KW  - helminths
KW  - Human diseases
KW  - immune evasion
KW  - immunity
KW  - parasites
KW  - Digenea
KW  - man
KW  - Schistosoma
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosomatidae
KW  - Digenea
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of pathologic changes in mammalian hosts infected with Schistosoma mansoni, S. japonicum and S. haematobium.
AU  - Cheever, A. W.
JO  - Memórias do Instituto Oswaldo Cruz
JF  - Memórias do Instituto Oswaldo Cruz
Y1  - 1987///
VL  - 82
IS  - Suppl. 4
SP  - 39
EP  - 45
SN  - 0074-0276
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA.
N1  - Accession Number: 19900868756.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 44 ref. Subject Subsets: Helminthology
N2  - The differences and similarities of the hepatic, intestinal and cardiopulmonary lesions produced by S. mansoni, S. haematobium and S. japonicum in humans and animals are reviewed and discussed.
KW  - helminths
KW  - Human diseases
KW  - Laboratory animals
KW  - lesions
KW  - parasites
KW  - pathology
KW  - Schistosomiasis
KW  - Brazil
KW  - Digenea
KW  - man
KW  - rodents
KW  - Schistosoma haematobium
KW  - Schistosoma japonicum
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - bilharzia
KW  - bilharziasis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anti-schistosomal drugs: observations on the mechanism of drug resistance to hycanthone, and on the involvement of host antibodies in the mode of action of praziquantel.
AU  - Brindley, P. J.
AU  - Sher, A.
JO  - Memórias do Instituto Oswaldo Cruz
JF  - Memórias do Instituto Oswaldo Cruz
Y1  - 1987///
VL  - 82
IS  - Suppl. 4
SP  - 157
EP  - 161
SN  - 0074-0276
AD  - Brindley, P. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910868810.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 24 ref. Registry Number: 3105-97-3, 55268-74-1.  Subject Subsets: Helminthology
N2  - Recent observations on hycanthone (HC) and praziquantel (PZA) are reported. A laboratory model of drug resistance to hycanthone in Schistosoma mansoni is discussed and it is demonstrated that drug sensitive and resistant lines of the parasite can be differentiated on the basis of restriction fragment length polymorphisms using homologous ribosomal gene probes. Data are summarized demonstrating that effective chemotherapy of S. mansoni infection with praziquantel in mice requires the presence of host anti-parasite antibodies. These antibodies bind to praziquantel-treated worms and may be involved in antibody-dependent cellular cytotoxicity reactions which result in the clearance of worms from the blood vessels of the liver.
KW  - Anthelmintics
KW  - Antibodies
KW  - drug resistance
KW  - helminths
KW  - Human diseases
KW  - hycanthone
KW  - mode of action
KW  - parasites
KW  - praziquantel
KW  - resistance mechanisms
KW  - Schistosomiasis
KW  - Brazil
KW  - Digenea
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - bilharzia
KW  - bilharziasis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Receptor-mediated clearance of Aspergillus galactomannan.
AU  - Bennett, J. E.
AU  - Friedman, M. M.
AU  - Dupont, B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1987///
VL  - 155
IS  - 5
SP  - 1005
EP  - 1010
SN  - 0022-1899
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901207476.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The fate of radiolabelled A. fumigatus galactomannan was studied after intravenous injection into rabbits and rats. At 1 h the liver contained 35% of the injected dose in rabbits and 30% in rats. Excretion of galactomannan into the urine, measured in rabbits, was another major catabolic route and accounted for 35% of the dose by 24 h. Immunization of rabbits increased hepatic uptake and decreased urinary excretion. Hepatic uptake in unimmunized rats could be decreased by Saccharomyces cerevisiae mannan, α-methylmannoside and N-acetylglucosamine, known inhibitors of the macrophage mannose receptor. Autoradiography showed hepatic radiolabelled galactomannan to be concentrated in Kupffer cells, which express the mannosyl receptor for glycoproteins. It is suggested that macrophage mannosyl receptors may constitute a general mechanism for clearing fungal mannans from the bloodstream.
KW  - antigens
KW  - galactomannans
KW  - immunology
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - antigenicity
KW  - fungus
KW  - Hyphomycetes
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Description, mechanisms and control of reactions to treatment in the human filariases.
AU  - Ottesen, E. A.
A2  - Evered, D.
A2  - Clark, S.
T2  - Filariasis.
Y1  - 1987///
CY  - Chichester; UK
PB  - John Wiley and Sons Ltd.
SN  - 0471910937
AD  - Ottesen, E. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900864639.  Publication Type: Book chapter; Conference paper.  Language: English.  Number of References: 41 ref. Registry Number: 90-89-1, 1642-54-2.  Subject Subsets: Helminthology
N2  - The host reactions to the chemotherapy of the human filariases are discussed. The first section describes the reactions (the clinical manifestations and histopathology of the Mazzotti reaction in onchocerciasis, and the similar reactions associated with diethylcarbamazine (DEC) treatment in lymphatic filariasis, loiasis, streptocerciasis, and Mansonella perstans and M. ozzardi infections). The 2nd section explains the mechanisms underlying these adverse reactions (using data from studies in humans and animals), and the 3rd section advises on the control of the reactions (decreasing or spacing initial DEC doses, topical routes of administering DEC in onchocerciasis, the use of anti-inflammatory drugs, and the use of antifilarial drugs other than DEC).
KW  - Anthelmintics
KW  - diethylcarbamazine
KW  - DRUG THERAPY
KW  - Filariasis
KW  - filariids
KW  - helminths
KW  - Human diseases
KW  - parasites
KW  - Toxicity
KW  - man
KW  - Nematoda
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - chemotherapy
KW  - discussion
KW  - nematodes
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Iron status and cellular immune competence.
AU  - Good, M. F.
AU  - Powell, L. W.
AU  - Halliday, J. W.
JO  - Blood Reviews
JF  - Blood Reviews
Y1  - 1988///
VL  - 2
IS  - 1
SP  - 43
EP  - 49
SN  - 0268-960X
AD  - Good, M. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418827.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 7439-89-6.  Subject Subsets: Human Nutrition
N2  - From this review it is concluded that iron overload and Fe deficiency are associated with significant abnormalities of immune function. In diseases associated with Fe overload there is increased susceptibility to infection and neoplasia. The precise mechanisms are still not clear but Fe overload has been shown to impair antigen-specific immune responses and to reduce the number of functional helper precursor cells. Similarly, Fe in vitro in concentrations reported to be present in the serum of patients with Fe overload impairs the generation of cytotoxic T-cells, increases suppressor T-cell activity and reduces the proliferative capacity of helper T-cells. The predominant tumour seen in Fe overload is primary hepatocellular carcinoma, but other aetiological factors seem to be involved in addition to Fe overload, especially hepatic cirrhosis. Nevertheless, primary liver cancer occurs much more frequently in haemochromatosis than in other forms of cirrhosis. Fe deficiency is associated with an altered response to infection but the relation is complex. The cellular mechanisms involved have yet to be clearly defined, although impaired T and B cell function have been demonstrated.
KW  - immunity
KW  - Iron
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A method for determining the magnesium concentration of mononuclear blood cells.
AU  - Hosseini, J.
AU  - Elin, R. J.
JO  - Trace Elements in Medicine
JF  - Trace Elements in Medicine
Y1  - 1988///
VL  - 5
IS  - 2
SP  - 47
EP  - 51
AD  - Hosseini, J.: Clinical Pathology Department, Building 10, Room 2C-306, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901419945.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 7439-95-4.  Subject Subsets: Human Nutrition
N2  - Mononuclear blood cell (MBC) magnesium may provide a better index of intracellular Mg or total body Mg status than plasma or red blood cell (RBC) Mg. A method is described for the estimation of the Mg concentration of MBC, and results are reported with this method using blood from 20 normal persons. The method employs a Ficoll-Hypaque gradient for separation of cells, count and volume measurement with a particle analyser, and estimation of Mg by atomic absorption spectroscopy. The results (mean ± s.d.) show a MBC Mg concentration of 10.47 ± 2.01 mmol/litre and a MBC Mg content of 3.23 ± 0.67 fmol/cell. The results of Mg concentration and content were correlated significantly. There were no other significant correlations among plasma Mg concentration, RBC Mg concentration, MBC Mg concentration, MBC Mg content and age. Using Student's t-test, no differences were found between sex or race in any of the values measured. MBC Mg expressed as concentration is the preferred measurement as it is independent of the size of the cells in the population, and gives comparable units to other body tissues for Mg.
KW  - blood
KW  - estimation
KW  - Magnesium
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Deviations in brain development of F2 generational calorie undernutrition and scope of their prevention by rehabilitation: imbalances in the levels of noradrenaline, dopamine and serotonin in different brain regions.
AU  - Annamma, C.
AU  - Desiraju, T.
JO  - Biogenic Amines
JF  - Biogenic Amines
Y1  - 1988///
VL  - 5
IS  - 5
SP  - 323
EP  - 337
SN  - 0168-8561
AD  - Annamma, C.: T. Desiraju, Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India.
N1  - Accession Number: 19901450761.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - The effects of chronic energy undernutrition on ontogenetic imbalances in norepinephrine (NE), dopamine (DA) and serotonin (5HT) were assessed in different regions of F2 generation rat brain, and also the extent of protection possible by postweaning rehabilitatory nutrition. Whole-brain estimations revealed that NE and 5HT concentrations, but not DA, were significantly increased in the undernourished. Analysis of regions revealed that the increase of NE was significant in the olfactory bulb, ventral brainstem, hippocampus, cingulate-medial frontal region and motor cortex, while no such increase occurred in the visual cortex. DA increases were significant in the olfactory bulb and the cingulate region, but not in the other areas. 5HT increases were significant in all those areas, but in visual cortex the change was opposite. Postweaning nutritional rehabilitation has prevented some of these changes only, and significant abnormalities continued to persist in adult rats (150 days old). The NE aberrations were significantly prevented in the cingulate only. The DA aberration was significantly prevented in both olfactory bulb and cingulate. The 5HT aberration recovered in cingulate and motor cortex, but not in other regions.
KW  - brain
KW  - Malnutrition
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic control of vaccine-induced immunity against a parasitic helminth, Schistosoma mansoni.
AU  - Sher, A.
AU  - James, S.
JO  - BioEssays
JF  - BioEssays
Y1  - 1988///
VL  - 9
IS  - 5
SP  - 163
EP  - 166
SN  - 0265-9247
AD  - Sher, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900865534.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Helminthology
N2  - Approaches to vaccination against S. mansoni in mice, the most commonly used experimental model for schistosomiasis, congenital immunodeficiencies influencing the resistance induced by an attenuated vaccine, genetic analysis of P-mouse vaccine defects, gene loci influencing vaccine-induced immunity, and genetic control of immunity induced by a non-living vaccine are discussed.
KW  - genetic control
KW  - helminths
KW  - Human diseases
KW  - immunization
KW  - Laboratory animals
KW  - parasites
KW  - Vaccines
KW  - Digenea
KW  - mice
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - discussion
KW  - immune sensitization
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calcium and colon cancer: a review.
AU  - Sorenson, A. W.
AU  - Slattery, M. L.
AU  - Ford, M. H.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1988///
VL  - 11
IS  - 3
SP  - 135
EP  - 145
SN  - 0163-5581
AD  - Sorenson, A. W.: National Institutes of Health, National Institute on Aging, Geriatrics Branch, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911436889.  Publication Type: Journal Article.  Language: English.  Number of References: 61 ref. Registry Number: 7440-70-2.  Subject Subsets: Human Nutrition
N2  - Epidemiological data are reviewed to evaluate the role of dietary calcium as a protective factor in the aetiology of colon cancer; ecological and analytical epidemiological studies are examined. Biological evidence explaining mechanisms whereby Ca intake could alter risk of developing colon cancer is also presented. The data reviewed generally support the hypothesis that dietary Ca is linked to colon cancer in a protective manner. It may be one component in the aetiology of colon cancer which alters an individual's risk of developing the disease.
KW  - calcium
KW  - Carcinoma
KW  - colon
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911436889&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mortality among agricultural extension agents.
AU  - Alavanja, M. C. R.
AU  - Blair, A.
AU  - Merkle, S.
AU  - Teske, J.
AU  - Eaton, B.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 167
EP  - 176
SN  - 0271-3586
AD  - Alavanja, M. C. R.: Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Public Health Service, US Department of Health and Human Services, Executive Plaza North, Room 543, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900501643.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2  - The death of agricultural extension agents employed by the Cooperative Extension Service (CES) of the US Department of Agriculture, who died between 1 January 1970 and 31 December 1979 (n = 1495 white males), was evaluated in proportionate-mortality and case-control studies. Proportionate-mortality analysis was used to identify cancers in this occupational group which could be compared with the US white male population as a whole. All cancers with a significantly elevated proportionate-mortality ratio were more thoroughly evaluated in the case-control study, where there is presumably less of a selection bias in the comparison. In the case-control study, cases of leukaemia were linearly correlated with duration of employment as an extension agent. Smaller, but non-significant, trends were seen for non-Hodgkin's lymphoma, multiple myeloma and brain cancer. The odds ratio for Hodgkin's disease and cancers of the colon, prostate and kidney did not vary with the number of years employed. The cancer distribution patterns resembled those seen among farmers, suggesting that agricultural factors may also play a role in the origin of cancerous tumours among extension agents.
KW  - agricultural entomology
KW  - Agriculture
KW  - Death
KW  - Disease surveys
KW  - effects
KW  - Epidemiology
KW  - extension agents
KW  - Farm workers
KW  - Health
KW  - Leukaemia
KW  - mortality
KW  - Neoplasms
KW  - Nontarget effects
KW  - Occupational hazards
KW  - pesticides
KW  - North America
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - blood cancer
KW  - cancers
KW  - death rate
KW  - disease surveillance
KW  - leucaemia
KW  - leukemia
KW  - United States of America
KW  - Occupational Health and Safety (VV900) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Aquatic Biology and Ecology (MM300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemotaxonomic implications of the venom chemistry of some Monomorium "antarcticum" populations.
AU  - Jones, T. H.
AU  - Stahly, S. M.
AU  - Don, A. W.
AU  - Blum, M. S.
JO  - Journal of Chemical Ecology
JF  - Journal of Chemical Ecology
Y1  - 1988///
VL  - 14
IS  - 12
SP  - 2197
EP  - 2212
SN  - 0098-0331
AD  - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900597308.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A comparative analysis of the venom alkaloids produced by ants in the genus Monomorium collected from 28 locations on North Island and South Island, New Zealand, was undertaken. All of the ants produce trans-2,5-dialkylpyrrolidines along with 3,5-dialkylpyrrolizidines. The structures and sterochemistry of the novel alkaloids trans-2-butyl-5-(8-nonenyl)pyrrolidine, (5E,8Z)-3,5-di(5-hexenyl)pyrrolizidine and (5Z,8E)-3-methyl-5-(8-nonenyl)pyrrolizidine were established by unambiguous synthesis. The geographic distribution and the chemotaxonomic significance of the alkaloids produced by these ants are discussed. The M. antarcticum complex in New Zealand is thought to contain 4-7 species, based on this biochemical analysis.
KW  - Alkaloids
KW  - biochemistry
KW  - Chemotaxonomy
KW  - Sibling species
KW  - Taxonomy
KW  - venoms
KW  - New Zealand
KW  - Oceania
KW  - Formicidae
KW  - Hymenoptera
KW  - Monomorium
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Formicidae
KW  - Monomorium
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - biochemical taxonomy
KW  - Monomorium antarcticum
KW  - systematics
KW  - venom
KW  - Plant Composition (FF040) 
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice.
AU  - Khillan, J. S.
AU  - Deen, K. C.
AU  - Yu, S.
AU  - Sweet, R. W.
AU  - Rosenberg, M.
AU  - Westphal, H.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1988///
VL  - 16
IS  - 4
SP  - 1423
EP  - 1430
SN  - 0305-1048
AD  - Khillan, J. S.: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890168593.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology
N2  - Transgenic mice were generated carrying either the long terminal repeat of human immunodeficiency virus fused to the bacterial chloramphenicol acetyltransferase reporter gene, or a control element of the mouse αA crystallin gene fused to the tat gene of human immunodeficiency virus. By crossing the 2 transgenic strains, progeny were obtained which carried both transgenes. The bacterial reporter gene was specifically transactivated in the eyes of these animals.
KW  - Biotechnology
KW  - crystallins
KW  - experiments
KW  - Eyes
KW  - gene expression
KW  - Genes
KW  - Genetic engineering
KW  - germ line
KW  - HIV infections
KW  - Molecular biology
KW  - Transactivation
KW  - transgenics
KW  - tropisms
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - genetic manipulation
KW  - human immunodeficiency virus infections
KW  - insertion
KW  - mouse
KW  - transcriptional activation
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mung bean nuclease exhibits a generalized gene-excision activity upon purified Plasmodium falciparum genomic DNA.
AU  - Vernick, K. D.
AU  - Imberski, R. B.
AU  - McCutchan, T. F.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1988///
VL  - 16
IS  - 14
SP  - 6883
EP  - 6896
SN  - 0305-1048
AD  - Vernick, K. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890859864.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Protozoology
N2  - A novel set of reaction conditions for mung bean nuclease was previously described in which Plasmodium genes were specifically excised as intact fragments from purified DNA. Under the new conditions mung bean nuclease cleaves precisely at sites outside of the coding region of every P. falciparum gene for which the extent of the protein coding region in genomic DNA is known, suggesting that this enzyme activity is probably a general one for P. falciparum genes. Introns were not specifically cleaved, although one gene contained a cleavage site within an intron. There was no direct relationship between dA.dT-richness and sites of cleavage under these conditions. Also contrary to the expectations of a model based on cleavage at denaturation bubbles, there was no general relationship between the concentration of the DNA denaturant, formamide, and the size of the resulting gene-containing fragments. Thus, the data strongly suggest the involvement of an altered DNA structure near gene boundaries in determining the recognition sites for this enzyme activity.
KW  - Human diseases
KW  - molecular genetics
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - genomic DNA
KW  - mung bean nuclease cleavage
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Receptors for gut hormones.
AU  - Gardner, J.
AU  - Jensen, R.
JO  - Italian Journal of Gastroenterology
JF  - Italian Journal of Gastroenterology
Y1  - 1988///
VL  - 20
IS  - 5
SP  - 281
EP  - 286
SN  - 0392-0623
AD  - Gardner, J.: National Institutes of Health Building 10, Room 9C-103 Bethesda, MD 20892, USA.
N1  - Accession Number: 19901416969.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Human Nutrition
N2  - This lecture discusses the receptors within the gastrointestinal endocrine system for the gut hormones cholecystokinin, secretin and gastrin.
KW  - Gastrointestinal hormones
KW  - receptors
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gastric hormones
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901416969&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The genetics and expression of an esterase locus in Anopheles gambiae.
AU  - Vernick, K. D.
AU  - Collins, F. H.
AU  - Seeley, D. C.
AU  - Gwadz, R. W.
AU  - Miller, L. H.
JO  - Biochemical Genetics
JF  - Biochemical Genetics
Y1  - 1988///
VL  - 26
IS  - 5/6
SP  - 367
EP  - 379
SN  - 0006-2928
AD  - Vernick, K. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900598475.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The main polymorphic esterase isoenzymes in adults of the G3 laboratory strain of A. gambiae consists of 2-5 major bands of activity per individual. The bands are designated 5S, 5F, 13, 14 and 15. In genetic crosses, the genes which coded for the bands assorted as 3 codominant alleles, Est A, Est B and Est C, at a single autosomal locus. Homozygotes for the Est C allele were significantly underrepresented among backcross progeny. The developmental pattern of esterase expression was examined. Esterase gene expression in embryos was first detectable between 2 and 12 h after oviposition. The initiation or termination of expression of some of the bands corresponded to boundaries between developmental stages. Most of the esterase fractions were not specifically localized within the tissues tested, with the exception of a series of bands which were restricted largely to adult male testes.
KW  - Development
KW  - Enzymes
KW  - esterases
KW  - gene expression
KW  - genetics
KW  - Isoenzymes
KW  - molecular genetics
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - isozymes
KW  - mosquitoes
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Influences of aging and dietary restriction on serum thymosinα1 levels in mice.
AU  - Weindruch, R.
AU  - Naylor, P. H.
AU  - Goldstein, A. L.
AU  - Walford, R. L.
JO  - Journal of Gerontology
JF  - Journal of Gerontology
Y1  - 1988///
VL  - 43
IS  - 2
SP  - B40
EP  - B42
SN  - 0022-1422
AD  - Weindruch, R.: Biomedical Research and Clinical Medicine Program, National Institute on Aging, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901416981.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - Influences of age (3 weeks, 2, 7, 19 or 26 months old), long-term dietary restriction (DR) started at 3 weeks old and acute starvation on serum thymosinα1 (Tα1) values were measured by radioimmunoassay in female mice from a long-lived strain. Average Tα1 value was highest (about 60 ng/ml) at 3 weeks and fell sharply such that mice 2 months old fed on normal (N, about 80% of free intake) or restricted (R, about 50% of free intake) diets averaged about 20 ng/ml. Any age-related decreases after 2 months old were mild and significant only for R mice bled 2 to 4 h (but not 24 to 48 h) after feeding. Tα1 values were lower in group R than in group N mice in one experiment at 19 months old but not in another at 26 months old. The decline with age in serum Tα1 is mainly a very early life event for mice of this hybrid strain and seems uninfluenced by DR. Tα1 values are variably reduced by DR later in life.
KW  - age
KW  - blood
KW  - food intake
KW  - Thymus hormones
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901416981&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antigenic variation of Giardia lamblia in vivo.
AU  - Aggarwal, A.
AU  - Nash, T. E.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1988///
VL  - 56
IS  - 6
SP  - 1420
EP  - 1423
SN  - 0019-9567
AD  - Aggarwal, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900862609.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Protozoology
N2  - Gerbils were inoculated with defined G. lamblia clones and the surface antigens of the intestinal trophozoites were studied at different times during the infection. The proportion of MAb 6E7-reacting trophozoites from WB C1-6E7S-inoculated gerbils had decreased significantly by day 3 postinoculation, indicating the presence of a heterogeneous population. On day 7, the 170 000 MW antigen was no longer present and was replaced by a variety of antigens, including a major protein of 92 000 MW. With the exception of isolates from gerbils inoculated with WB A6-6E7S, the banding patterns of G. lamblia isolated from gerbils on day 7 or later were the same regardless of the clones used for inoculation. These studies show that G. lamblia changes its surface antigen(s) in vivo within 7 days following inoculation and appears to maintain the same set of surface antigens during the course of infection.
KW  - antigenic variation
KW  - Antigens
KW  - Human diseases
KW  - immunology
KW  - Laboratory animals
KW  - parasites
KW  - Giardia duodenalis
KW  - Meriones unguiculatus
KW  - protozoa
KW  - Rodents
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Meriones
KW  - Gerbillinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - antigenic polymorphism
KW  - antigenicity
KW  - Giardia lamblia
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862609&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aspartame intolerance.
AU  - Garriga, M. M.
AU  - Metcalfe, D. D.
JO  - Annals of Allergy
JF  - Annals of Allergy
Y1  - 1988///
VL  - 61
IS  - 6,II
SP  - 63
EP  - 69
SN  - 0003-4738
AD  - Garriga, M. M.: D.D. Metcalfe, Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 11C210, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901419312.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 22839-47-0.  Subject Subsets: Human Nutrition
N2  - From a review of research on aspartame it is concluded that although concern has been expressed over its widespread use analysis of adverse reaction reports and available clinical data suggests that it is remarkably safe. Reports documenting allergic reactions are rare.
KW  - Aspartame
KW  - safety
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419312&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Structure-function studies on Acanthamoeba myosins IA, IB and II.
AU  - Korn, E. D.
AU  - Atkinson, M. A. L.
AU  - Brzeska, H.
AU  - Hammer, J. A., III
AU  - Jung, G.
AU  - Lynch, T. J.
JO  - UCLA Symposia on Molecular and Cellular Biology, New Series
JF  - UCLA Symposia on Molecular and Cellular Biology, New Series
Y1  - 1988///
VL  - 77
SP  - 69
EP  - 82
AD  - Korn, E. D.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861018.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Subject Subsets: Protozoology
N2  - This paper was originally published in Journal of Cellular Biochemistry (1988) 36 (1), 37-50 and has been abstracted (see Protozoological Abstracts (1988) 12, No 2353).
KW  - biochemistry
KW  - Human diseases
KW  - myosins
KW  - parasites
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food choices and the cancer guidelines.
AU  - Patterson, B. H.
AU  - Block, G.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988///
VL  - 78
IS  - 3
SP  - 282
EP  - 286
SN  - 0090-0036
AD  - Patterson, B. H.: Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901417827.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
N2  - Diet of a representative sample of 11 658 non-institutionalized civilian adults 19 to 74 years old in the USA included in the second National Health and Nutrition Examination Survey of 1976-80 was studied by 24-h recall in relation to subsequent cancer guidelines of the US National Research Council and the American Cancer Society. Cruciferous vegetables, fruits and vegetables rich in vitamin A and high-fibre breads and cereals were consumed by only 18, 21 and 16% of the population sample, compared with 55% for red meat and 43% for bacon and luncheon meats. Numbers using fruit and vegetables increased with income. Diets of women, black persons and older age groups came closest to the guidelines.
KW  - Carcinogenesis
KW  - diets
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417827&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calories, fat and cholesterol: intake patterns in the US population by race, sex and age.
AU  - Block, G.
AU  - Rosenberger, W. F.
AU  - Patterson, B. H.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988///
VL  - 78
IS  - 9
SP  - 1150
EP  - 1155
SN  - 0090-0036
AD  - Block, G.: Surveillance and Operations Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza No., Room 313, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901450913.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Human Nutrition
N2  - Nutrient intakes were investigated for black and white subjects using 24-h dietary recall data from the Second National Health and Nutrition Examination Survey (NHANES II, 1976-80). The study included a total of 10 322 white and 1336 black adults 19 to 74 years old. Intake of energy, total fat, saturated fat, dietary cholesterol, ratio of polyunsaturated fats to saturated fats (P:S) and percentage of energy derived from total and saturated fat were examined by sex and age. Black subjects had a lower intake of energy and fats than white persons and a consistently higher intake of dietary cholesterol. The P:S ratio was higher in women than in men, but all groupings by sex and age were substantially below recommended amounts. Percentage of energy from total and saturated fat was similar in most age and sex groupings. Possible explanations of the patterns to include activity level and metabolic differences are suggested.
KW  - age
KW  - ethnic groups
KW  - intake
KW  - Nutrients
KW  - sex differences
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450913&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary factors in oral and pharyngeal cancer.
AU  - McLaughlin, J. K.
AU  - Gridley, G.
AU  - Block, G.
AU  - Winn, D. M.
AU  - Preston-Martin, S.
AU  - Schoenberg, J. B.
AU  - Greenberg, R. S.
AU  - Stemhagen, A.
AU  - Austin, D. F.
AU  - Ershow, A. G.
AU  - Blot, W. J.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1988///
VL  - 80
IS  - 15
SP  - 1237
EP  - 1243
SN  - 0027-8874
AD  - McLaughlin, J. K.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, Room 415, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418840.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - A population-based case-control study of oral and pharyngeal cancer in 4 areas of the USA provided information on a number of risk factors, including diet. Interviews were obtained from 871 oral cancer patients and 979 controls among white persons, frequency-matched for age and sex. Consumption frequency of 61 food items was assessed in the questionnaire; attention was given to foods that are sources of vitamins A and C and carotene. The major finding was an inverse relation between fruit intake and risk of oral and pharyngeal cancer; persons in the highest quartile of intake had about half the risk of those in the lowest quartile. Vitamin C, carotene or fibre in fruit did not seem to account completely for this relation as these nutrients in vegetables did not provide similar protection. This finding suggests the influence of other constituents in fruits, although it is possible that cooking vegetables may have a nutrient-diminishing effect. Dietary intake of other nutrients, such as the B vitamins, vitamin E, folate and iron, showed no consistent relation to risk of oral and pharyngeal cancer. Coffee or other hot beverage consumption did not increase risk; intake of nitrite-containing meats or cooking practices, such as smoking, pickling or charcoal grilling, also did not increase risk. All analyses were adjusted for the effects of tobacco and alcohol, strong risk factors for oral and pharyngeal cancer. Dietary findings among the few subjects who did not use tobacco or alcohol were similar to those for all subjects.
KW  - Carcinoma
KW  - diets
KW  - mouth
KW  - pharynx
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418840&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Breast-feeding incidence and duration in black and white women.
AU  - Kurinij, N.
AU  - Shiono, P. H.
AU  - Rhoads, G. G.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1988///
VL  - 81
IS  - 3
SP  - 365
EP  - 371
SN  - 0031-4005
AD  - Kurinij, N.: Epidemiology Branch, Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900441288.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Dairy Science; Human Nutrition
N2  - The influence of socio-demographic factors on the incidence and duration of breast-feeding was evaluated in 668 black and 511 white women delivering their first child in the metropolitan Washington, DC, USA, area. Breast-feeding rates were 84% among white and 49% among black women. Maternal educational level was strongly associated with breast-feeding, whereas the effect of ethnicity was moderate. Women with some college or some graduate school education had adjusted odds of breast-feeding that were 2.6 (95% confidence limit 1.9 to 3.7) and 5.2 (95% confidence limit 2.7 to 10.2) times higher than women with a high school education or less. In contrast, the adjusted odds of breast-feeding were 2.0 (95% confidence limit 1.4 to 3.1) times higher for white women compared with black women. The odds of breast-feeding increased among black women if they attended childbirth classes, were married or were older. Among black women, the frequency of breast-feeding decreased sharply by 1 month post partum. Breast-feeding duration for black vs. white women was 74 vs. 90% at 1 month, 44 vs. 72% at 4 months and 26 vs. 50% at 7 months post partum. The majority of black women (53%) used formula supplements in the hospital, which was the only factor significantly related to a shortened duration in this group (P&lt;0.01). The high rate of formula supplementation among black women and its strong association with shortened duration of breast-feeding indicate a need for more advice and support, and less reliance on formula during the hospital stay.
KW  - Breast feeding
KW  - duration
KW  - education
KW  - ethnic groups
KW  - incidence
KW  - infants
KW  - District of Columbia
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Education, Extension, Information and Training (General) (CC000) 
KW  - Milk and Dairy Produce (QQ010) 
KW  - Human Nutrition (General) (VV100) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The contribution of enrichment and fortification to nutrient intake of women.
AU  - Subar, A. F.
AU  - Bowering, J.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1988///
VL  - 88
IS  - 10
SP  - 1237
EP  - 1242, 1245
SN  - 0002-8223
AD  - Subar, A. F.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-4200, USA.
N1  - Accession Number: 19911453553.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - A group of 162 women, 25 to 49 years old was recruited from 3 suburban supermarkets in central New York State, USA. The women completed 3-day food records, which were analysed for total nutrient intake and contribution of 8 nutrients from 3 sources: nutrients naturally present in food, enriched/fortified foods with a standard of identity (FF + SI), and fortified foods without standards of identity (FF - SI). Subjects were placed into study groups of high-, moderate- and low-fortifiers on the basis of frequency of intake of highly fortified foods (FF - SI). For all groups, mean intakes of riboflavin, niacin and vitamins A and C were greater than 100% of the recommended daily allowances (RDA) without nutrient addition. Mean thiamin intake met the RDA only when the nutrient addition from FF + SI was included. Mean intakes of iron, calcium and vitamin D were all below the RDA even when all sources of intake were included. No significant differences between study groups were found for total nutrient intake. With the exceptions of vitamin C, vitamin D and Ca, high- and moderate-fortifiers had significantly greater nutrient intake from fortification. Low-fortifiers had greater intake from naturally occurring vitamins A and C than had high-fortifiers.
KW  - diet studies
KW  - Women
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453553&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The National Cholesterol Education Program: implications for dietetic practitioners from the Adult Treatment Panel Recommendations.
AU  - Ernst, N. D.
AU  - Cleeman, J.
AU  - Mullis, R.
AU  - Sooter-Bochenek, J.
AU  - Horn, L. van
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1988///
VL  - 88
IS  - 11
SP  - 1401
EP  - 1408
SN  - 0002-8223
AD  - Ernst, N. D.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911453571.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition
N2  - Background information on the organization and objectives of the USA National Cholesterol Education Programme are discussed, focusing on the recommendations of the Adult Treatment Panel, e.g., classification of risk for developing coronary heart disease based on total and low-density-lipoprotein cholesterol concentrations and recommendations for treatment of patients with high blood cholesterol. The emphasis of the discussion is on dietary treatment. The implications of the recommendations for the dietetic practitioner are discussed. These include an expanded leadership role to meet the education needs of health professionals and patients.
KW  - Nutrition education
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453571&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Erythrocyte lipids in alcohol dependence.
AU  - Sanjeev Jain
AU  - Shetty, K. T.
AU  - Rajat Ray
AU  - Janakiramaiah, N.
JO  - Indian Journal of Medical Research
JF  - Indian Journal of Medical Research
Y1  - 1988///
VL  - 88
IS  - December
SP  - 530
EP  - 535
AD  - Sanjeev Jain: K. T. Shetty, Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India.
N1  - Accession Number: 19911432693.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - Erythrocyte lipid content, particularly cholesterol (CHL) and phospholipids (PL), was studied in 30 alcoholics and 26 age-matched controls. Haematological and liver function tests in the alcoholics indicated the onset of complications associated with alcoholism. Although alcoholism did not affect plasma CHL and PL values it caused an increase in CHL in erythrocytes and decreases in PL in erythrocytes and in erythrocyte number.
KW  - Alcoholism
KW  - erythrocytes
KW  - lipids
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood red cells
KW  - lipins
KW  - red blood cells
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Caffeinated beverages and decreased fertility.
AU  - Wilcox, A.
AU  - Weinberg, C.
AU  - Baird, D.
JO  - Lancet
JF  - Lancet
Y1  - 1988///
VL  - ii
IS  - 8626-8627
SP  - 1453
EP  - 1456
AD  - Wilcox, A.: Epidemiology Branch, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NG 27709, USA.
N1  - Accession Number: 19921445362.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 58-08-2.  Subject Subsets: Human Nutrition
N2  - A total 104 healthy women who had been attempting to become pregnant for 3 months were interviewed about their use of caffeinated beverages, alcohol and cigarettes. In their subsequent cycles, women who consumed more than the equivalent of one cup of coffee per day were half as likely to become pregnant, per cycle, as women who drank less. A dose-response effect was present.
KW  - Caffeine
KW  - Fertility
KW  - Women
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445362&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - T cells, T sites, and malaria immunity - further optimism for vaccine development.
AU  - Good, M. F.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1988///
VL  - 140
IS  - 6
SP  - 1715
EP  - 1716
SN  - 0022-1767
AD  - Good, M. F.: The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900865425.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Protozoology
N2  - Recent work on the role of T lymphocytes in immunity to malaria, and T-cell epitopes in malaria antigens is discussed with reference to malaria vaccine development.
KW  - epitopes
KW  - Human diseases
KW  - immune response
KW  - parasites
KW  - T lymphocytes
KW  - vaccines
KW  - Apicomplexa
KW  - Plasmodium
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - antigenic determinants
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of antigens and antibodies specific for Pneumocystis carinii.
AU  - Kovacs, J. A.
AU  - Halpern, J. L.
AU  - Swan, J. C.
AU  - Moss, J.
AU  - Parrillo, J. E.
AU  - Masur, H.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1988///
VL  - 140
IS  - 6
SP  - 2023
EP  - 2031
SN  - 0022-1767
AD  - Kovacs, J. A.: Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861598.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Protozoology
N2  - To increase understanding of P. carinii and its interaction with its hosts, antigens specific for rodent and human P. carinii were identified by the immunoblot method after PAGE of P. carinii extracts. The MWs of the major antigens of rat P. carinii were 45 000, 110 000, and a broad band of 49 000 to 64 000, and of human P. carinii were 22 000, 24 000, and a broad band of 35 000 to 45 000. Human and rat Pneumocystis were not antigenically identical. Specific antibodies against rat P. carinii antigen were found in 18 of 79 rats by the immunoblot method. Specific antibodies against human P. carinii antigen were found in 32 of 33 adult human sera, but in only 1 of 8 sera from infants and children. Specific antibodies were found in sera of 13 of the 14 adults with no history of P. carinii pneumonia, and all 19 patients with recently diagnosed P. carinii pneumonia, including 9 patients with P. carinii pneumonia associated with AIDS. The results of this study support previous suggestions that a large proportion of adults have been exposed to P. carinii and provide a basis for the further investigations of host-P. carinii interactions.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antigens
KW  - Human diseases
KW  - immune response
KW  - Immunocompromised hosts
KW  - Laboratory animals
KW  - Opportunistic infections
KW  - parasites
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - rats
KW  - Rodents
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - Muridae
KW  - rodents
KW  - AIDS
KW  - antigenicity
KW  - fungus
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861598&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis carinii pneumonia: therapy and prophylaxis.
AU  - Kovacs, J. A.
AU  - Masur, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1988///
VL  - 158
IS  - 1
SP  - 254
EP  - 259
SN  - 0022-1899
AD  - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910880511.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Protozoology
N2  - The current status of drugs available for therapy and prevention of P. carinii pneumonia in AIDS patients is assessed. The drugs considered include trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine and sulfadiazine in combination, dapsone, trimetrexate, difluoromethylornithine, clindamycin-primaquine and zidovudine (for prophylaxis). Treatment regimens, mode of administration, efficacies and toxicity are discussed
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antiinfective agents
KW  - antiprotozoal agents
KW  - clinical aspects
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - Prophylaxis
KW  - reviews
KW  - Treatment
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - antimicrobials
KW  - chemotherapy
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enhanced diagnostic specificity in human filariasis by IgG4 antibody assessment.
AU  - Lal, R. B.
AU  - Ottesen, E. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1988///
VL  - 158
IS  - 5
SP  - 1034
EP  - 1037
SN  - 0022-1899
AD  - Lal, R. B.: E.A. Ottesen, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900865828.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 308067-58-5, 308067-57-4.  Subject Subsets: Helminthology; Tropical Diseases
N2  - By configuring an enzyme immunoassay (ELISA) to assess antibodies of the IgG4 subclass only (because patients with filariasis usually generate a vigorous IgG4 antibody response to the infection, as well as because humans do not usually mount an IgG4 response to phosphocholine epitopes, a common cross-reactive determinant) serological false-positive results were eliminated in 32 of 34 cross-reactive sera from patients with non-filarial parasitic infections. Specificity was thus greatly enhanced with minimal loss of sensitivity. Because preadsorption of these cross-reactive sera to remove antibodies to PC eliminated only ~50% of the original cross-reactivity, it is suggested that other shared epitopes (perhaps similar to phosphocholine) are also likely to be restricted by IgG subclass.
KW  - antibodies
KW  - ELISA
KW  - Filariasis
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - IgG
KW  - immunodiagnosis
KW  - Immunoglobulins
KW  - parasites
KW  - man
KW  - Nematoda
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - enzyme linked immunosorbent assay
KW  - gamma-globulins
KW  - IgG4
KW  - immune globulins
KW  - nematodes
KW  - parasitic worms
KW  - serological diagnosis
KW  - specificity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular basis for mutation in a surface protein expressed by malaria parasites.
AU  - Hudson, D. E.
AU  - Wellems, T. E.
AU  - Miller, L. H.
JO  - Journal of Molecular Biology
JF  - Journal of Molecular Biology
Y1  - 1988///
VL  - 203
IS  - 3
SP  - 707
EP  - 714
SN  - 0022-2836
AD  - Hudson, D. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869175.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology
N2  - Plasmodium knowlesi parasites isolated from a rhesus monkey vaccinated with a 143 000/140 000 MW merozoite surface protein no longer expressed this protein. To study the molecular basis for the mutations, a λgt11 cDNA expression library constructed from the original parasite clone was screened with rabbit antiserum specific for the 143 000/140 000 MW protein. Two cDNA clones that mapped to the 5′ and 3′ ends of the gene hybridized to 2 chromosomes of 3.6×106 kb and 1.8×106 kb. The gene on the 3.6×106 base chromosome was identified as the gene expressing the 143 000/140 000 MW protein. Since the 2 cDNA clones also hybridized at high stringency with the 1.8×106 base chromosome, it appeared that the 143 000/140 000 MW gene was involved in an ancestral duplication and interchromosomal transposition. Mutant parasites were analysed using the cDNA clones and a 7000 base fragment of genomic DNA that contained the 143 000/140 000 MW gene. In one type of mutation, the 143 000/140 000 MW protein was replaced by a 76 000/72 000 MW protein. The identical restriction sites and the identical size of the mRNA indicated that a point mutation resulted in premature interruption of translation. Sequence analysis revealed an AT substitution for a C in the middle of the coding region of the gene that created a frameshift and a stop codon. In a 2nd type of mutation, no protein was expressed; a 4000 base deletion encompassed the transcriptional unit of the gene. The rapid mutation under vaccine pressure of an otherwise stable parasite protein emphasizes the need to identify vaccine candidates in which mutations would be lethal.
KW  - Biotechnology
KW  - DNA libraries
KW  - genes
KW  - Merozoites
KW  - mutations
KW  - parasites
KW  - surface proteins
KW  - Vaccines
KW  - Apicomplexa
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - membrane proteins
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunogenicity and epitope mapping of foreign sequences via genetically engineered filamentous phage.
AU  - Cruz, V. F. de la
AU  - Lal, A. A.
AU  - McCutchan, T. F.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1988///
VL  - 263
IS  - 9
SP  - 4318
EP  - 4322
SN  - 0021-9258
AD  - Cruz, V. F. de la: Malaria Division, Laboratory for Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890165678.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Animal Breeding; Protozoology
N2  - Repeat regions of the circumsporozoite protein gene of Plasmodium falciparum were cloned into the pIII gene of a filamentous phage, which displayed the recombinant proteins on its surface. Injection of recombinant phages produced an antibody response in C57BL/10 mice, but not in BALB/c mice. The antibody response appeared to be controlled by Ir genes.
KW  - antigens
KW  - Disease models
KW  - Human diseases
KW  - immune response
KW  - immunization
KW  - Immunogenetics
KW  - Laboratory animals
KW  - major histocompatibility complex
KW  - molecular genetics
KW  - parasites
KW  - Vaccines
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - antigenicity
KW  - biochemical genetics
KW  - histocompatibility complex
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - recombinant circumsporozoite protein gene
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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ER  - 

TY  - JOUR
T1  - Transient impaired glucose tolerance in Pima Indians: is it important?
AU  - Saad, M. F.
AU  - Knowler, W. C.
AU  - Pettitt, D. J.
AU  - Nelson, R. G.
AU  - Bennett, P. H.
JO  - British Medical Journal (Clinical Research edition)
JF  - British Medical Journal (Clinical Research edition)
Y1  - 1988///
VL  - 297
IS  - 6661
SP  - 1438
EP  - 1441
SN  - 0959-8138
AD  - Saad, M. F.: Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA.
N1  - Accession Number: 19901418751.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - As part of a continuing epidemiological study of noninsulin-dependent diabetes among Pima Indians in Arizona, USA, 154 subjects who had had a transient impairment of glucose tolerance were followed-up for 1.2 to 16.9, median 5.8 years after their glucose tolerance had returned to normal. Of these, 49 subsequently developed diabetes, 26 subsequently developed impaired glucose tolerance and 79 had normal glucose tolerance at the last examination. The cumulative incidence of diabetes was 16 and 48% at 5 and 10 years of follow-up, respectively, compared with 3 and 8% for a control group of 1245 members of the same population. After adjustment for age, sex, body mass index and plasma glucose concentration 2 h after glucose loading the incidence of diabetes among the subjects who had had transient impaired glucose tolerance was 3.0 times that among the controls (95% confidence interval 2.1 to 4.3). Proportional hazards function analysis indicated that obesity was the most important predictor of subsequent development of diabetes. The results suggest that transient impairment of glucose tolerance indicates, at least in some subjects a predisposition to diabetes and should not be considered clinically unimportant.
KW  - ethnic groups
KW  - Glucose tolerance
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood sugar tolerance
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies.
AU  - Kovacs, J. A.
AU  - Ng, V. L.
AU  - Masur, H.
AU  - Leoung, G.
AU  - Hadley, W. K.
AU  - Evans, G.
AU  - Lane, C.
AU  - Ognibene, F. P.
AU  - Shelhamer, J.
AU  - Parrillo, J. E.
AU  - Gill, V. J.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1988///
VL  - 318
IS  - 10
SP  - 589
EP  - 593
SN  - 0028-4793
AD  - Kovacs, J. A.: Bld. 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900862799.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Public Health; Protozoology
N2  - Two prospective studies were carried out to assess whether an indirect immunofluorescent stain using MAbs was more sensitive than Giemsa or toluidine blue O staining for detecting P. carinii in sputum samples. Of 63 patients at one institution from whom sputum specimens were obtained, 49 were ultimately given a diagnosis of P. carinii pneumonia, 46 of them by staining of sputum. The sensitivity of the 3 stains in detecting P. carinii was 45 of 49 (92%) for immunofluorescence, 37 of 49 (76%) for Diff-Quik (a Giemsa-type stain), and 39 of 49 (80%) for toluidine blue O. There were no false positive immunofluorescent stains. In a similar study of a series of 225 patients at another institution, a diagnosis of P. carinii pneumonia was made in 23 of 25 patients by staining of induced sputum. Examination of induced sputum is considered a rapid, sensitive and inexpensive method for the diagnosis of P. carinii pneumonia; indirect immunofluorescence was a practical and highly sensitive staining technique.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors evaluated the examination of induced sputum for Pneumocystis carinii using 3 staining methods and compared it with bronchoalveolar lavage. Of 63 patients, 49 were diagnosed as having P. carinii pneumonia. 46 were positive on stained sputum that was obtained after the patient inhaled a nebulized mist of 3% saline for 5-15 minutes which induced coughing. The stains compared were toluidine blue O, Giemsa and immunofluorescence with monoclonal antibodies that react with P. carinii. The sensitivity of the stains were 92% for immunofluorescence, 80% for toluidine blue O and 76% for Giemsa. They conclude that examination of induced sputum is an acceptable alternative method for the diagnosis of P. carinii to bronchoalveolar lavage and that indirect immunofluorescence is the staining method of choice.G.W. Csonka&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors evaluated the examination of induced sputum for Pneumocystis carinii using 3 staining methods and compared it with bronchoalveolar lavage. Of 63 patients, 49 were diagnosed as having P. carinii pneumonia. 46 were positive on stained sputum that was obtained after the patient inhaled a nebulized mist of 3% saline for 5-15 minutes which induced coughing. The stains compared were toluidine blue O, Giemsa and immunofluorescence with monoclonal antibodies that react with P. carinii. The sensitivity of the stains were 92% for immunofluorescence, 80% for toluidine blue O and 76% for Giemsa. They conclude that examination of induced sputum is an acceptable alternative method for the diagnosis of P. carinii to bronchoalveolar lavage and that indirect immunofluorescence is the staining method of choice.G.W. Csonka
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - clinical aspects
KW  - detection
KW  - Diagnosis
KW  - HIV infections
KW  - Human diseases
KW  - immunodiagnosis
KW  - Monoclonal antibodies
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - sputum
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus infections
KW  - indirect immunofluorescent stain
KW  - induced sputum
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.
AU  - Vogel, J.
AU  - Hinrichs, S. H.
AU  - Reynolds, R. K.
AU  - Luciw, P. A.
AU  - Jay, G.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1988///
VL  - 335
IS  - 6191
SP  - 606
EP  - 611
SN  - 0028-0836
AD  - Vogel, J.: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890173661.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology
N2  - When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region was introduced into the germ line of mice, skin lesions were induced that resemble Kaposi's sarcoma.
KW  - Biotechnology
KW  - genes
KW  - Genetic engineering
KW  - germ line
KW  - human immunodeficiency viruses
KW  - neoplasms
KW  - Sarcoma
KW  - transgenics
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - genetic manipulation
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - insertion
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Human nutrition.
AU  - Burton, B. T.
AU  - Foster, W. R.
T2  - Human nutrition.
Y1  - 1988///
IS  - Ed. 4
CY  - New York; USA
PB  - McGraw-Hill Book Company
AD  - Burton, B. T.: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19901418562.  Publication Type: Book.  Language: English.  Subject Subsets: Human Nutrition
N2  - This is the fourth edition of the book formerly titled 'The Heinz Handbook of Nutrition', and includes sections covering utilization of foods, the food elements, nutrition in health and disease, and the role of nutrition in modern life. There are major additions in the areas of disease prevention, cancer, cardiovascular diseases, calcium, osteoporosis, obesity, anorexia nervosa and bulimia, alcoholism, total parenteral nutrition, and food allergy and toxicology. There are no references but 2 appendices cover the composition and nutritive value of foods (including food composition tables) and there is a subject index.
KW  - nutrition
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Long-range restriction studies of Plasmodium falciparum chromosomes.
AU  - Wellems, T. E.
A2  - Turner, M. J.
A2  - Arnot, D.
T2  - Molecular genetics of parasitic protozoa.
JO  - Molecular genetics of parasitic protozoa.
JF  - Molecular genetics of parasitic protozoa.
Y1  - 1988///
SP  - 30
EP  - 32
CY  - Cold Spring Harbor, New York; USA
PB  - Cold Spring Harbor Laboratory
SN  - 0879693134
AD  - Wellems, T. E.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874687.  Publication Type: Conference paper.  Language: English.  Number of References: 9 ref. Subject Subsets: Protozoology
KW  - Chromosomes
KW  - molecular genetics
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - Human diseses
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Ecological and epidemiological considerations of Rocky Mountain spotted fever and scrub typhus.
AU  - Burgdorfer, W.
A2  - Walker, D.H.
T2  - Biology of rickettsial diseases. Volume I.
JO  - Biology of rickettsial diseases. Volume I.
JF  - Biology of rickettsial diseases. Volume I.
Y1  - 1988///
SP  - 33
EP  - 50
CY  - Boca Raton, Florida; USA
PB  - CRC Press, Inc.
SN  - 0849343828
AD  - Burgdorfer, W.: National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
N1  - Accession Number: 19900599139.  Publication Type: Miscellaneous.  Language: English.  Number of References: 116 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The ecology and epidemiology of the zoonotic diseases caused by Rickettsia rickettsii and R. tsutsugamushi are discussed, with emphasis on tick and trombiculid vectors and animal hosts.
KW  - disease transmission
KW  - disease vectors
KW  - epidemiology
KW  - Human diseases
KW  - reviews
KW  - Tickborne diseases
KW  - transmission
KW  - Vectors
KW  - Zoonoses
KW  - Japan
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Ixodidae
KW  - Orientia tsutsugamushi
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Trombiculidae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Metastigmata
KW  - Acari
KW  - Orientia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Rickettsia
KW  - Prostigmata
KW  - mites
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - North America
KW  - America
KW  - bacterium
KW  - Rickettsia tsutsugamushi
KW  - United States of America
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antigenic variation in Giardia lamblia.
AU  - Nash, T. E.
A2  - Turner, M.J.
A2  - Arnot, D.
T2  - Molecular genetics of parasitic protozoa.
JO  - Molecular genetics of parasitic protozoa.
JF  - Molecular genetics of parasitic protozoa.
Y1  - 1988///
SP  - 164
EP  - 166
CY  - Cold Spring Harbor, New York; USA
PB  - Cold Spring Harbor Laboratory
SN  - 0879693134
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874710.  Publication Type: Conference paper.  Language: English.  Number of References: 2 ref. Subject Subsets: Protozoology
KW  - antigenic variation
KW  - antigens
KW  - molecular genetics
KW  - parasites
KW  - Giardia duodenalis
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - biochemical genetics
KW  - Giardia lamblia
KW  - immunogens
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Carcinoma of the urinary bladder associated with schistosomiasis in Egypt: the possible causal relationship.
AU  - Tawfik, H. N.
A2  - Miller, R. W.
A2  - Watanabe, S.
A2  - Fraumeni, J. F., Jr.
A2  - Sugimura, T.
A2  - Takayama, S.
A2  - Sugano, H.
T2  - Unusual occurrences as clues to cancer etiology.
JO  - Unusual occurrences as clues to cancer etiology.
JF  - Unusual occurrences as clues to cancer etiology.
Y1  - 1988///
SP  - 197
EP  - 209
CY  - Tokyo, Japan; Scientific Societies Press: London, UK; Japan
PB  - Taylor & Francis Ltd
SN  - 4762215562\0850664594
AD  - Tawfik, H. N.: Department of Pathology, National Cancer Institute, Cairo University, Egypt.
N1  - Accession Number: 19900863036.  Publication Type: Conference paper.  Language: English.  Number of References: 57 ref. Subject Subsets: Helminthology
N2  - The epidemiology of Schistosoma haematobium infection in Africa and Egypt in particular, and the factors that suggest a causal relationship between schistosomiasis and bladder cancer are outlined. The results of a study carried out in Egypt between 1982 and 1986, on the relationship between the intensity of schistosome egg deposition and various clinicopathological features of 264 cases of carcinoma of the bladder are presented. There was no significant correlation between age, sex, the involved trigone of the bladder, or type of carcinoma and the intensity of egg deposition. Early detection of schistosomal bladder cancer, the immunopathology of Schistosoma-associated bladder cancer, the possible role of schistosomiasis as a vesical carcinogen and factors against this theory are discussed.
KW  - Aetiology
KW  - bladder
KW  - carcinoma
KW  - helminths
KW  - Human diseases
KW  - neoplasms
KW  - parasites
KW  - Pathology
KW  - Africa
KW  - Egypt
KW  - Digenea
KW  - man
KW  - Schistosoma haematobium
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - Misr
KW  - parasitic worms
KW  - Strigeida
KW  - urinary bladder
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Immunological consequences of polymorphism in circumsporozoite proteins.
AU  - Cruz, V. F. de la
AU  - Maloy, W. L.
AU  - Miller, L. H.
AU  - Lal, A. A.
AU  - Good, M. F.
AU  - McCutchan, T. F.
A2  - Lasky, L.
T2  - Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA).
JO  - Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA).
JF  - Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA).
Y1  - 1988///
SP  - 615
EP  - 624
CY  - New York; USA
PB  - Alan R. Liss, Inc.
SN  - 0845126830
AD  - Cruz, V. F. de la: Malaria Division, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869088.  Publication Type: Conference paper.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology
N2  - The discovery of polymorphism in T cell determinants of the circumsporozoite protein of Plasmodium falciparum may have a profound effect on the development of a sporozoite derived anti-malaria vaccine. The effects of polymorphism on T cell activity were tested in mice and a general lack of cross-reactivity was found. Polymorphism in T cell determinants may thus indicate that infection with sporozoites will not necessarily boost immune (antibody and/or cytotoxic) responses stimulated by prior infections or by a subunit vaccine.
KW  - circumsporozoite protein
KW  - Human diseases
KW  - immune response
KW  - Laboratory animals
KW  - parasites
KW  - polymorphism
KW  - T lymphocytes
KW  - Vaccines
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - technological advances in vaccine development
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869088&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Conserved sequences of the HSP gene family in Giardia lamblia.
AU  - Aggarwal, A.
AU  - Romans, P.
AU  - Cruz, V. F. de la
AU  - Nash, T. E.
A2  - Wallis, P. M.
A2  - Hammond, B. R.
T2  - Advances in Giardia research.
Y1  - 1988///
CY  - Alberta; Canada
PB  - University of Calgary Press
SN  - 0919813860
AD  - Aggarwal, A.: NIAD, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879381.  Publication Type: Conference paper; Book chapter.  Language: English.  Number of References: 11 ref. Subject Subsets: Protozoology
N2  - Transformation of G. lamblia [G. duodenalis] from trophic form to the cystic form is thought to be induced by a heat shock response. A factor was found in nuclear extract of Giardia trophozoites bound to heat shock element of Drosophila hsp 70. The sequence analysis of the 5′ flanking area showed a TATAA box at position -28 to -33 upstream to the initiation site and consensus promoter region at -56 to -69. The level of this factor was significantly increased after heat shock.
KW  - Biotechnology
KW  - genes
KW  - heat shock proteins
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - Giardia
KW  - GIARDIA DUODENALIS
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Giardia
KW  - biochemical genetics
KW  - DNA sequences
KW  - Hsp 70
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879381&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Biological differences in Giardia lamblia.
AU  - Nash, T. E.
AU  - Aggarwal, A.
A2  - Wallis, P. M.
A2  - Hammond, B. R.
T2  - Advances in Giardia research.
Y1  - 1988///
CY  - Alberta; Canada
PB  - University of Calgary Press
SN  - 0919813860
AD  - Nash, T. E.: National Institutes of Health, NIAIB, LPD, Building 5, Rm 118 Bethesda, MD 20205, USA.
N1  - Accession Number: 19920879359.  Publication Type: Conference paper; Book chapter.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology
N2  - Six-week-old Mongolian gerbils were infected with 2 unique human isolates of Giardia, GS/E and WB. All WB inoculated gerbils became infected and were able to self-cure by day 28 pi. In contrast, GS/E infected gerbils tended to remain infected. After treatment, previously WB infected gerbils resisted infection after re-challenge with WB and GS/E, while GS/E infected gerbils partially resisted re-challenge with GS/E. All were infected with WB. Resistance to infection correlated with the development of cytotoxic antibodies which reacted with the surface of the Giardia. Experimental infections in humans confirmed that Giardia isolates differed biologically. In the first study, 5 volunteers were enterally inoculated with 50 000 trophozoites of isolates GS/M or Isr, followed serially and treated on day 15 post inoculation. In the 2nd study, 2 of the previously inoculated, infected and treated volunteers were re-challenged along with 5 new volunteers as controls. All 10 of the GS/M inoculated volunteers became infected compared to none of the 5 inoculated with Isr. Both re-challenged individuals became infected although one only transiently shed cysts. Of the 10 infected, 5 became ill, 4 with diarrhoea and typical symptoms of giardiasis. Humoral immune responses to Giardia occurred in all infected volunteers. It is concluded that these experiments give credence to the idea that Giardia are not only biochemically different, but also differ in their biological behaviour.
KW  - Experimental infections
KW  - Giardiasis
KW  - Human diseases
KW  - Immunology
KW  - infectivity
KW  - Laboratory animals
KW  - parasites
KW  - strains
KW  - Giardia
KW  - GIARDIA DUODENALIS
KW  - Hexamitidae
KW  - man
KW  - Meriones unguiculatus
KW  - Muridae
KW  - protozoa
KW  - Rodents
KW  - Sarcomastigophora
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Giardia
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Meriones
KW  - Gerbillinae
KW  - Muridae
KW  - rodents
KW  - Biological differences
KW  - giardiosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879359&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Malarial proteins at the membrane of Plasmodium falciparum-infected erythrocytes and their involvement in cytoadherence to endothelial cells.
AU  - Howard, R. J.
A2  - Perlmann, P.
A2  - Wigzell, H.
T2  - Malaria Immunology.
Y1  - 1988///
CY  - Basel; Switzerland
PB  - S. Karger AG
SN  - 3805546726
AD  - Howard, R. J.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861845.  Publication Type: Book chapter.  Language: English.  Number of References: 118 ref. Subject Subsets: Protozoology
N2  - This review covers cytoadherence and knobs, receptors for infected erythrocytes on endothelial cells, properties of the cytoadherent moiety on infected cells, malarial proteins at the infected erythrocyte membrane, malarial transferrin receptor, Pf 11.1, other P. falciparum proteins and changes at the erythrocyte membrane, experiments to define the cytoadherent moiety, and clinical applications.
KW  - cytoadherence
KW  - host parasite relationships
KW  - Human diseases
KW  - immunology
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - cell adhesion
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861845&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antigenic diversity in Plasmodium falciparum.
AU  - McCutchan, T. F.
AU  - Cruz, V. F. de la
AU  - Good, M. F.
AU  - Wellems, T. E.
A2  - Perlmann, P.
A2  - Wigzell, H.
T2  - Malaria Immunology.
Y1  - 1988///
CY  - Basel; Switzerland
PB  - S. Karger AG
SN  - 3805546726
AD  - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861847.  Publication Type: Book chapter.  Language: English.  Number of References: 56 ref. Subject Subsets: Protozoology
N2  - This review focuses on the possible effects of both T and B epitope variations on developing immunity to P. falciparum, and the occurrence of antigenic variation in Plasmodium. The circumsporozoite protein, the S antigen and histidine-rich proteins are discussed.
KW  - antigens
KW  - Human diseases
KW  - immunology
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - antigenic diversity
KW  - antigenicity
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861847&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Genetically determined human resistance factors.
AU  - Miller, L. H.
A2  - Wernsdorfer, W.H.
A2  - McGregor, I.
T2  - Malaria: principles and practice of malariology. Volume 1.
Y1  - 1988///
CY  - Edinburgh; UK
PB  - Churchill Livingstone
SN  - 0443024170
AD  - Miller, L. H.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19900861481.  Publication Type: Book chapter.  Language: English.  Number of References: 102 ref. Subject Subsets: Protozoology
N2  - Factors influencing sporozoite infectivity and exoerythrocytic development, erythrocytic factors influencing the asexual erythrocytic parasite, the genetics of immune responsiveness and the genetic control of resistance to Plasmodium berghei are discussed.
KW  - Human diseases
KW  - malaria
KW  - parasites
KW  - resistance
KW  - Apicomplexa
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - host genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861481&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Advances in the biology and immunology of Pneumocystis carinii.
AU  - Kovacs, J. A.
AU  - Masur, H.
A2  - Leech, J.H.
A2  - Sande, M.A.
A2  - Root, R.K.
T2  - Parasitic infections.
Y1  - 1988///
CY  - New York; USA
PB  - Churchill Livingstone
SN  - 0443085617
AD  - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910871891.  Publication Type: Book chapter.  Language: English.  Number of References: 43 ref. Subject Subsets: Protozoology
N2  - Advances in the biology and immunology of P. carinii are discussed under several headings including: morphology, histopathology, and life cycle; biochemical studies; immunofluorescence and ELISA studies; immunoblot results; application of monoclonal antibodies. The studies performed and results in relation to AIDS patients are discussed.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Antibodies
KW  - ELISA
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - immunology
KW  - Opportunistic infections
KW  - parasites
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - enzyme linked immunosorbent assay
KW  - fungus
KW  - general account
KW  - human immunodeficiency virus
KW  - parasitic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Biologic differences among isolates of Giardia lamblia.
AU  - Nash, T. E.
A2  - Leech, J.H.
A2  - Sande, M.A.
A2  - Root, R.K.
T2  - Parasitic infections.
Y1  - 1988///
CY  - New York; USA
PB  - Churchill Livingstone
SN  - 0443085617
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910871888.  Publication Type: Book chapter.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology
N2  - Biological differences among isolates of G. lamblia are discussed with reference to studies on endonuclease restriction analysis of DNA, surface antigens, and evaluation of biological differences. Evidence gained through these studies is presented.
KW  - Biotechnology
KW  - Human diseases
KW  - Molecular genetics
KW  - parasites
KW  - strain differences
KW  - Trophozoites
KW  - Giardia duodenalis
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - Giardia lamblia
KW  - parasitic infections
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Recent advances in the diagnosis and management of leishmaniasis and American trypanosomiasis.
AU  - Neva, F. A.
A2  - Leech, J.H.
A2  - Sande, M.A.
A2  - Root, R.K.
T2  - Parasitic infections.
Y1  - 1988///
CY  - New York; USA
PB  - Churchill Livingstone
SN  - 0443085617
AD  - Neva, F. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910871894.  Publication Type: Book chapter.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology
N2  - This chapter gives an insight into recent advances in the diagnosis and management of leishmaniasis and American trypanosomiasis. The diagnosis of Leishmania is discussed under the headings: specimen collection in cutaneous and mucocutaneous leishmaniasis; leishmanial culture for cutaneous and mucocutaneous disease; new technology for detection and speciation of Leishmania; serology in diagnosis; special considerations in diagnosis of kala-azar; new use of old drugs in treatment; local treatment of cutaneous leishmaniasis. Trypanosoma cruzi infection is discussed under the headings: serodiagnosis; is chronic Chagas' disease caused by certain varieties of T. cruzi?; antigen detection as an aid to diagnosis; chemotherapy of Chagas' disease.
KW  - Antiprotozoal agents
KW  - Chagas' disease
KW  - Cutaneous leishmaniasis
KW  - diagnosis
KW  - drug therapy
KW  - Human diseases
KW  - Mucocutaneous leishmaniasis
KW  - parasites
KW  - reviews
KW  - Trypanocides
KW  - Visceral leishmaniasis
KW  - Leishmania
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Trypanosoma
KW  - chemotherapy
KW  - espundia
KW  - parasitic infections
KW  - trypanocidal drugs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The statistical analysis of a carcinogen mixture experiment. III. Carcinogens with different target systems, aflatoxin B1, N-butyl-N-(4-hydroxybutyl)nitrosamine, lead acetate, and thiouracil.
AU  - Fears, T. R.
AU  - Elashoff, R. M.
AU  - Schneiderman, M. A.
JO  - Toxicology and Industrial Health
JF  - Toxicology and Industrial Health
Y1  - 1989///
VL  - 5
IS  - 1
SP  - 1
EP  - 23
SN  - 0748-2337
AD  - Fears, T. R.: Biostatistics Branch, National Cancer Institute, Washington, DC, USA.
N1  - Accession Number: 19901205748.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Factorial experiments designed to determine whether 2 carcinogens that lead to cancers in different organ systems act synergistically to produce cancers in Fisher 344 rats are described. Four carcinogens, aflatoxin B1, N-butyl-N-(4-hydroxybutyl)nitrosamine, lead acetate and thiouracil were studied in paired combinations. Each of the 6 possible pairs were studied by means of a 4×4 factorial experiment, each agent being fed at zero and at 3 non-zero doses. Methods of analysis designed explicitly for this study were derived to study interaction. These methods were supplemented by standard statistical methods appropriate for single agent studies. Neither synergism nor antagonism was demonstrated in these combined exposure studies. Findings for male and female animals were consistent.
KW  - Aflatoxins
KW  - carcinogenesis
KW  - Mycotoxins
KW  - poisoning
KW  - toxicity
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fungal toxins
KW  - toxicosis
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lysosomal membrane transport in cellular nutrition.
AU  - Gahl, W. A.
JO  - Annual Review of Nutrition
JF  - Annual Review of Nutrition
Y1  - 1989///
VL  - 9
SP  - 39
EP  - 61
SN  - 0199-9885
AD  - Gahl, W. A.: Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901419333.  Publication Type: Journal Article.  Language: English.  Number of References: 122 ref. Subject Subsets: Human Nutrition
N2  - A host of cellular nutrients are synthesized within the cell itself or enter directly via transport across the plasma membrane, but a significant portion of the small molecules necessary for a cell's growth and metabolism require passage through the lysosome or a similar acidic vesicular compartment. These nutrients arrive in the lysosome by hydrolysis of macromolecules or by receptor-mediated endocytosis. They leave by carrier-mediated transport or, it is speculated, by intermembrane transfer in the case of lipophilic substances. In either case, a vesicular membrane provides the key to communication between the lysosome and the cytosol, and that membrane now requires intensive study. The success of future pursuits in this area will be aided by an increased recognition of the importance of the lysosome-to-cytosol step in cellular metabolism. For example, investigators might ask how iron gets out of endosomes, or how thyroxine gets out of lysosomes. In addition, naturally occurring mutations, or inborn errors of metabolism, provide invaluable opportunities to delineate a normal pathway, using the mutant for comparison. Physicians and scientists alike can advance our knowledge of lysosomal membrane transport by increasing their collective index of suspicion that unknown lysosomal storage disorders might represent transport defects, rather than strictly enzymic defects.
KW  - Cells
KW  - lysosomes
KW  - nutrition
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selenium metabolism and selenium-dependent enzymes in microorganisms.
AU  - Axley, M. J.
AU  - Stadtman, T. C.
JO  - Annual Review of Nutrition
JF  - Annual Review of Nutrition
Y1  - 1989///
VL  - 9
SP  - 127
EP  - 137
SN  - 0199-9885
AD  - Axley, M. J.: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901419342.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
KW  - metabolism
KW  - Selenium
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The influence of zinc supplementation on glucose homeostasis in NIDDM.
AU  - Raz, I.
AU  - Karsai, D.
AU  - Katz, M.
JO  - Diabetes Research
JF  - Diabetes Research
Y1  - 1989///
VL  - 11
IS  - 2
SP  - 73
EP  - 79
SN  - 0265-5985
AD  - Raz, I.: I. Raz, National Institutes of Health, 4212 North 16th Street, Room 5441-A, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19921444963.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 50-99-7, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - Serum zinc and 24-h urine in 97 patients with non-insulin-dependent diabetes mellitus (NIDDM) were compared with values in 62 age- and sex-matched healthy persons. Urine Zn was significantly increased in the diabetic group. For 7 to 8 weeks 13 diabetics with high urine Zn and low serum Zn were given zinc sulphate 220 mg, 3 times daily. Glucose disposal decreased significantly whereas values for fasting glucose increased significantly from 177 ± 10 to 207 ± 15 mg/100 ml and those for fructosamine from 2.7 ±0.2 to 3.2 ± 0.28%. T-lymphocyte response to phytohaemagglutinin increased significantly. It is concluded that Zn supplements may aggravate the glucose intolerance of NIDDM patients with high serum Zn and low urine Zn. Zn supplements are not recommended for such patients until more accurate methods are available to assess Zn deficiency.
KW  - Diabetes
KW  - Glucose
KW  - Metabolism
KW  - Supplements
KW  - Zinc
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dextrose
KW  - Human Nutrition (General) (VV100) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921444963&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of vitamin-A status on hamster tracheal epithelium in vivo and in vitro.
AU  - Luca, L. M. de
AU  - McDowell, E. M.
JO  - Food and Nutrition Bulletin
JF  - Food and Nutrition Bulletin
Y1  - 1989///
VL  - 11
IS  - 3
SP  - 20
EP  - 24
SN  - 0379-5721
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MS, USA.
N1  - Accession Number: 19901425378.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - How vitamin A and the retinoids control epithelial morphology and function is reviewed particularly in regard to the tracheal epithelium of the Syrian golden hamster. The new concept of extrophic cells, i.e., cells that have conditionally escaped the need for an essential nutrient, such as vitamin A, is suggested. These exotrophs might become fixed by a mutation and eventually contribute to the tumorigenic phenotype.
KW  - epithelium
KW  - morphology
KW  - Retinoids
KW  - Retinol
KW  - hamsters
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A compounds
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425378&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Research priorities and strategies for investigation of the influence of vitamin-A supplementation on morbidity.
AU  - Forman, M. R.
JO  - Food and Nutrition Bulletin
JF  - Food and Nutrition Bulletin
Y1  - 1989///
VL  - 11
IS  - 3
SP  - 25
EP  - 35
SN  - 0379-5721
AD  - Forman, M. R.: Cancer Prevention Studies Branch, National Cancer Institute, Rockville, MD, USA.
N1  - Accession Number: 19901425379.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Recent clinical and field research in vitamin A and morbidity is reviewed and the epidemiologic evidence for the association between vitamin A deficiency and morbidity is examined.
KW  - epidemiology
KW  - morbidity
KW  - Retinol
KW  - reviews
KW  - Vitamin A deficiency
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - hypovitaminosis A
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425379&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ethical issues related to nutrition field trials.
AU  - Porter, J. P.
JO  - Food and Nutrition Bulletin
JF  - Food and Nutrition Bulletin
Y1  - 1989///
VL  - 11
IS  - 3
SP  - 36
EP  - 40
SN  - 0379-5721
AD  - Porter, J. P.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19901425380.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Fundamental ethical principles related to nutrition field trials, provisions of the USA federal regulations for the protection of human subjects, and deliberations of the Subcommittee on Vitamin A Deficiency Prevention and Control regarding ethical concerns in studies on vitamin A are reviewed.
KW  - ethics
KW  - research
KW  - Retinol
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - studies
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425380&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Underpinning vitamin-A deficiency prevention and control programmes.
AU  - Underwood, B. A.
JO  - Food and Nutrition Bulletin
JF  - Food and Nutrition Bulletin
Y1  - 1989///
VL  - 11
IS  - 3
SP  - 41
EP  - 42
SN  - 0379-5721
AD  - Underwood, B. A.: National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19901425381.  Publication Type: Journal Article.  Language: English.  Number of References: 1 ref. Subject Subsets: Human Nutrition
N2  - From a discussion of vitamin A deficiency prevention and control programmes it is concluded that until a demand for a programme or a product is created, i.e. convert programme recipients into programme consumers, whether for a high-dose capsule, lower-cost green leafy vegetables or better means of preparing and preserving foods rich in vitamin A for young children, it is difficult to conceive of achieving the effective sustained behavioural change that must occur to eradicate and control vitamin A deficiency.
KW  - prevention
KW  - treatment
KW  - Vitamin A deficiency
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hypovitaminosis A
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425381&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical and biophysical studies on schistosomal liver of mice.
AU  - El-Aaser, A.
AU  - El-Merzabani, M. M.
AU  - Zakhary, N. I.
AU  - Farag, H. I.
AU  - Abdeen, A. M.
AU  - El-Salam, I. A.
AU  - Mokhtar, N. M.
JO  - Egyptian Journal of Bilharziasis
JF  - Egyptian Journal of Bilharziasis
Y1  - 1989///
VL  - 11
IS  - 1-2
SP  - 19
EP  - 33
AD  - El-Aaser, A.: Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 19930807782.  Publication Type: Journal Article.  Language: English.  Language of Summary: Arabic.  Number of References: 35 ref. Subject Subsets: Helminthology
N2  - The quantity and rates of synthesis of nucleic acids, lipids, proteins and carbohydrates in liver homogenates of 60 Swiss albino mice infected sc with 70-100 Schistosoma mansoni cercariae and 60 uninfected controls, were determined. In infected mice there was a significant increase in DNA content and synthesis, determined by ³H-thymidine incorporation, whereas RNA levels and rate of synthesis were unchanged. Significant changes were also observed in the enzymes (5′ nucleotidase, alkaline phosphatase, acid phosphatase, acid ribonuclease) involved in nucleic acid metabolism. There was no change in the level of hepatic total lipids and phospholipids in infected mice although a decrease in cholesterol levels was observed. The rate of lipid synthesis was significantly increased whereas that of phospholipids was reduced. A reduction in glucose-6-phosphatase and glycogen levels was observed in the liver of infected mice which was restored following thyroxine treatment, indicating that thyroxine receptors are not affected by schistosomiasis. Total liver proteins and rate of synthesis were not altered in infected mice, although aspartate and alanine aminotransferase activities were increased.
KW  - disease models
KW  - experimental infections
KW  - helminths
KW  - laboratory animals
KW  - liver
KW  - parasites
KW  - pathology
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - N-acetyltransferase activity in bilharzial infested mice.
AU  - Zakhary, N. I.
AU  - Dahawy, H. S.
AU  - El-Aaser, A. A.
JO  - Egyptian Journal of Bilharziasis
JF  - Egyptian Journal of Bilharziasis
Y1  - 1989///
VL  - 11
IS  - 1-2
SP  - 165
EP  - 169
AD  - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 19930807801.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Helminthology
N2  - The effect of Schistosoma haematobium infection on N-acetyltransferase enzyme systems was examined by estimating the percentage of N-acetylation of sulfadiazine-HCl (10 mg administered orally) in serum, liver and duodenal homogenates of S. haematobium infected albino mice. N-acetylation was significantly decreased in infected mice compared with the controls, and this is thought to indicate that schistosomal infection increases susceptibility to arylamine carcinogenesis. In both infected and control mice, liver homogenates showed the highest N-acetylation activity.
KW  - duodenum
KW  - experimental infections
KW  - helminths
KW  - laboratory animals
KW  - liver
KW  - parasites
KW  - pathogenesis
KW  - serum
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma haematobium
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - acetyltransferase
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807801&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pathophysiology of the Lyme disease spirochete, Borrelia burgdorferi, in ixodid ticks.
AU  - Burgdorfer, W.
AU  - Hayes, S. F.
AU  - Corwin, D.
A2  - Andriole, V.T.
JO  - Reviews of Infectious Diseases
JF  - Reviews of Infectious Diseases
Y1  - 1989///
VL  - 11
SP  - S1442
EP  - S1450
AD  - Burgdorfer, W.: Laboratory of Pathobiology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930518188.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The pathophysiology of B. burgdorferi is unique in tick/vector relationships, differing substantially from that of other spirochaetes, e.g. B. duttonii, the agent of tick-borne relapsing fever, and B. recurrentis, the agent of louse-borne relapsing fever, in their respective vectors. Following ingestion by a tick, B. burgdorferi lodges in the midgut diverticula, in some instances penetrating the gut wall and invading various tissues. Certain investigators suggest that transmission of the spirochaete occurs via infectious saliva, although, in light of the fact that only 5% of adult ticks are systemically infected, this mechanism is open to question. Alternatively, transmission may occur via periodic regurgitation of gut fluids during the feeding process.
KW  - disease transmission
KW  - Disease vectors
KW  - host parasite relationships
KW  - Infections
KW  - Transmission
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Ixodes
KW  - Ixodidae
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - bacterium
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518188&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevention of Pneumocystis carinii pneumonia.
AU  - Masur, H.
JO  - Reviews of Infectious Diseases
JF  - Reviews of Infectious Diseases
Y1  - 1989///
VL  - 11
SP  - S1664
EP  - S1668
AD  - Masur, H.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19920880619.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 100-33-4, 140-64-7.  Subject Subsets: Protozoology
N2  - Prophylaxis against P. carinii pneumonia (PCP) is reviewed. Target populations include those with human immunodeficiency virus infection, recent recipients of bone marrow or solid organ transplants, children with acute lymphocytic leukaemia and adults with T-cell leukaemia. The use of trimethoprim-sulfamethoxazole, pyrimethamine-sulfadoxine, and aerosolized pentamidine given once or twice monthly is discussed.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antiprotozoal agents
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pentamidine
KW  - prophylaxis
KW  - transplantation
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - pyrimethamine sulfadoxine
KW  - trimethoprim sulfamethoxazole
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The time course of sensory-specific satiety.
AU  - Hetherington, M.
AU  - Rolls, B. J.
AU  - Burley, V. J.
JO  - Appetite
JF  - Appetite
Y1  - 1989///
VL  - 12
IS  - 1
SP  - 57
EP  - 68
SN  - 0195-6663
AD  - Hetherington, M.: National Institute of Mental Health, Section of Biomedical Psychiatry, Building 10, Room 3S231, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901417624.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - The time course of the changes in hedonic response after ingestion of 3 different foods was investigated. Normal weight, non-dieting female subjects rated the pleasantness of the appearance, smell, texture and taste of 9 foods and then consumed as much as they wanted of cheese on cracker, tomato soup or orange jelly. After this first course, subjects re-rated the pleasantness of the foods at 2, 20, 40 and 60 min. After the 60-min rating, subjects were offered a second course of cheese on cracker or chocolate bar. For all sensory variables measured and for all foods consumed, the greatest decline in pleasantness occurred for the eaten food 2 min after consumption. For the food rated as most palatable (cheese on cracker) there was some recovery of pleasantness of the texture and taste over the hour. Intake in the second course was similar regardless of whether the food offered was different or the same as the food consumed in the first course. As changes in the pleasantness of the foods occurred rapidly for all sensory variables studied and as the magnitude of these changes did not increase over time, it is concluded that the development of sensory-specific satiety is related primarily to the sensory stimulation accompanying ingestion as opposed to the postabsorptive effects of consuming these foods.
KW  - Palatability
KW  - satiety
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417624&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Methionine lowers circulating levels of acetaldehyde after ethanol ingestion.
AU  - Tabakoff, B.
AU  - Eriksson, C. J. P.
AU  - Wartburg, J. P. von
JO  - Alcoholism: Clinical and Experimental Research
JF  - Alcoholism: Clinical and Experimental Research
Y1  - 1989///
VL  - 13
IS  - 2
SP  - 164
EP  - 171
SN  - 0145-6008
AD  - Tabakoff, B.: National Institute on Alcohol Abuse and Alcoholism/NIH, Building 10, Room 3C103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901450349.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 75-07-0, 64-17-5, 63-68-3.  Subject Subsets: Human Nutrition
N2  - When methionine was given to mice and rats which had been treated with ethanol there was a significant decrease in circulating acetaldehyde without change in circulating values of ethanol. Acetaldehyde values in liver were also decreased by methionine. Methionine was effective when given before or after the administration of ethanol, but the time course of the action of methionine suggested the necessity for metabolic transformation of the amino acid in order for the acetaldehyde-lowering effect to appear. Studies with healthy men and women, given methionine doses relatively of about one-tenth of those used with mice, indicated that methionine can also decrease acetaldehyde in persons ingesting ethanol. Given the toxic characteristics of acetaldehyde, methionine may prove effective in reducing the damaging effects of ethanol ingestion.
KW  - Acetaldehyde
KW  - blood
KW  - ethanol
KW  - methionine
KW  - animals
KW  - man
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - ethyl alcohol
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450349&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunocytochemical studies with antibodies to three proteins prominent in the isolated microtubule cytoskeleton of a trypanosomatid.
AU  - Bramblett, G. T.
AU  - Kambadur, R.
AU  - Flavin, M.
JO  - Cell Motility and the Cytoskeleton
JF  - Cell Motility and the Cytoskeleton
Y1  - 1989///
VL  - 13
IS  - 3
SP  - 145
EP  - 157
SN  - 0886-1544
AD  - Bramblett, G. T.: M. Flavin, Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Room B1-22, MD 20892, USA.
N1  - Accession Number: 19900860878.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Protozoology
N2  - The cytoskeleton of Crithidia fasciculata consists of a corset of parallel microtubules enclosing the cell body and closely underlying the plasma membrane. Distinct sets of crosslinks appear to connect tubules to each other and to the membrane. To determine the composition of these crosslinks and to elucidate the basis of this spectacular example of membrane-microtubule interaction, 3 proteins (designated COP-33, -41, and -61 by their subunit MW), which were consistently abundant in highly purified cytoskeletons, were purified. All bound strongly to microtubules in vitro, and the first 2 induced bundles through periodic crosslinking. Polyclonal antibodies against each were used to localize these proteins in thin sections of cells or whole mounts of cytoskeletons. Antibodies to COP-41 bound specifically to glycosomes, and COP-41 was identified as glyceraldehyde 3-P dehydrogenase.
KW  - biochemistry
KW  - cytoskeleton
KW  - microtubules
KW  - parasites
KW  - proteins
KW  - ultrastructure
KW  - Crithidia fasciculata
KW  - protozoa
KW  - Sarcomastigophora
KW  - Crithidia
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quantification of the putative neurotoxin 2-amino-3-(methylamino)propanoic acid (BMAA) in Cycadales: analysis of the seeds of some members of the family Cycadaceae.
AU  - Duncan, M. W.
AU  - Kopin, I. J.
AU  - Crowley, J. S.
AU  - Jones, S. M.
AU  - Markey, S. P.
JO  - Journal of Analytical Toxicology
JF  - Journal of Analytical Toxicology
Y1  - 1989///
VL  - 13
IS  - 3
SP  - 169
EP  - 175
SN  - 0146-4760
AD  - Duncan, M. W.: Intramural Research Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901417580.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Human Nutrition
KW  - neurotoxins
KW  - seeds
KW  - Cycadaceae
KW  - Cycadopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417580&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol consumption and breast cancer: a cross-national correlation study.
AU  - Schatzkin, A.
AU  - Piantadosi, S.
AU  - Miccozzi, M.
AU  - Bartee, D.
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1989///
VL  - 18
IS  - 1
SP  - 28
EP  - 31
SN  - 0300-5771
AD  - Schatzkin, A.: Division of Cancer Prevention and Control, National Cancer Institute, Blair Building, Room 6A-01, 9000 Rockville Pike, Bethesda, MA 20892, USA.
N1  - Accession Number: 19901419482.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Human Nutrition; Public Health
N2  - The cross-national correlation of alcohol consumption (based on food availability data from the Food and Agriculture Organization) and breast cancer was examined. Weighted correlation coefficients for alcohol and breast cancer were 0.31 for mortality and 0.65 for incidence; the corresponding unweighted coefficients were 0.50 and 0.45. Correlation coefficients for fat consumption and breast cancer ranged from 0.69 to 0.89. After adjustment for fat consumption in multiple regression models, the positive alcohol/breast cancer association disappeared, while the fat/breast cancer correlation remained positive and strong. These findings do not support the positive alcohol/breast cancer association that has been suggested by analytical epidemiological studies. The multivariate results, however, should be interpreted with caution due to the potential variation in the extent to which national alcohol data reflect consumption among females.
KW  - alcohol intake
KW  - alcoholic beverages
KW  - alcohols
KW  - breast
KW  - Carcinoma
KW  - health
KW  - mammary glands
KW  - neoplasms
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - alcohol consumption
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419482&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clinical trials in diet and cancer.
AU  - Byar, D. P.
AU  - Freedman, L. S.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1989///
VL  - 18
IS  - 2
SP  - 203
EP  - 219
SN  - 0091-7435
AD  - Byar, D. P.: Biometry Branch, Executive Plaza North, Room 344, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911439396.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Human Nutrition
N2  - The proposed plans for the Womens Health Trial, a dietary intervention trial aimed at reducing fat intake to 20% of energy intake, are described. The problems of using case-control and cohort studies to judge the plausibility of dietary hypotheses are discussed, and the advantages of randomized intervention trials are highlighted.
KW  - carcinoma
KW  - fats
KW  - intake
KW  - prevention
KW  - Women
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911439396&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human dietary assessment: methods and issues.
AU  - Block, G.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1989///
VL  - 18
IS  - 5
SP  - 653
EP  - 660
SN  - 0091-7435
AD  - Block, G.: Division of Cancer Prevention and Control, National Cancer Institute, EPN, Room 313, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19921443969.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
N2  - It is possible that a "good" diet may increase response to a chemopreventive agent, or that a diet deficient in some nutrients may weaken host defences or host response to the agent. Thus, dietary intake should be assessed in chemoprevention as well as dietary studies. The advantages and disadvantages of several methods are presented. Studies should attempt to assess the whole diet, not one or a few nutrients. Interpretation of the results of dietary studies can be seriously flawed and conclusions incorrect if only one or a few nutrients are assessed. Studies that ask about vegetable products but calculate only a fibre index are forced into drawing conclusions about fibre, when the true effective component may be elsewhere. Investigators should be cautious in the analysis and interpretation of results involving correlated nutrients. If variables are quite highly correlated, positively or negatively, a nutrient which has no effect may seem to have one, merely by correlation. Some examples are presented. Misclassification or measurement error is a serious problem for all dietary methods. For most frequency or few-day-record methods, sample sizes must be multiplied to accommodate measurement error.
KW  - Diet study techniques
KW  - Disease prevention
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443969&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A brief dietary screen for high fat intake.
AU  - Block, G.
AU  - Clifford, C.
AU  - Naughton, M. D.
AU  - Henderson, M.
AU  - McAdams, M.
JO  - Journal of Nutrition Education
JF  - Journal of Nutrition Education
Y1  - 1989///
VL  - 21
IS  - 5
SP  - 199
EP  - 207
SN  - 0022-3182
AD  - Block, G.: Executive Plaza North, Room 313, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901417510.  Publication Type: Journal Article.  Language: English.  Language of Summary: French; Spanish.  Number of References: 12 ref. Subject Subsets: Human Nutrition
N2  - A 13-item questionnaire was developed to identify groups with a high or low fat intake. It is intended as a rapid screening tool to identify those who may benefit from counselling or who could then be subjected to a more definitive dietary assessment. It may be self- or interviewer-administered. A correlation of r = 0.58 was observed between g total fat as estimated by the 13-item screener and g total fat as calculated from the mean of three 4-day diet records, among 101 women 45 years or more old. By dividing the screener fat distribution at its midpoint, 2 groups are identified which have 41 and 35% of energy from fat by diet records. The 13-item screener does nearly as well as 4-day diet record in correctly identifying those above and below the group's midpoint in percentage of energy from fat.
KW  - Fats
KW  - intake
KW  - screening
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - screening tests
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417510&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle.
AU  - Katz, A.
AU  - Nyomba, B. L.
AU  - Bogardus, C.
JO  - International Journal of Biochemistry
JF  - International Journal of Biochemistry
Y1  - 1989///
VL  - 21
IS  - 10
SP  - 1079
EP  - 1082
SN  - 0020-711X
AD  - Katz, A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19901417963.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - The effects of physiological concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact skeletal muscle of 7 healthy men 19 to 28 years old were studied. Insulin increased glucose 1,6-P2 from a basal value of 70 ± 6 to 135 ± 12 μmol/kg dry weight. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, inorganic phosphorus or citrate) or its substrate glucose 6-phosphate.
KW  - blood
KW  - insulin
KW  - Skeletal muscle
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - glucose 1,6-bisphosphate
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of DNA hybridization probes for detection of the plague bacillus (Yersinia pestis) in fleas (Siphonaptera: Pulicidae and Ceratophyllidae).
AU  - Thomas, R. E.
AU  - McDonough, K. A.
AU  - Schwan, T. G.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1989///
VL  - 26
IS  - 4
SP  - 342
EP  - 348
SN  - 0022-2585
AD  - Thomas, R. E.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19900597165.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - The detection of active plague in nature relies primarily on demonstration of the aetiologic agent of the disease, Y. pestis, in the flea vectors and susceptible mammalian hosts. A live animal assay is currently used for identification of a Y. pestis virulence antigen that is not expressed in the flea. It was found that DNA hybridization probes specific for Y. pestis, used in very simple sample preparation schemes, allow detection of Y. pestis in 3 species of fleas as well as tissues of experimentally infected mice at minimum concentrations of 1×106 bacillus/ml. Y. pestis was detected in 22 of 90 (24%) experimentally infected Xenopsylla cheopis, 13 of 25 (52%) Thrassis bacchi and 9 of 25 (36%) Diamanus montanus [Oropsylla montana], but no hybridization signals were observed from fleas that had fed on uninfected mice. The probe technique indicated infection in 9 of 10 potentially infected liver and spleen samples and none of the 5 control samples. The techniques permit definite diagnosis in 48 h.
KW  - Biotechnology
KW  - detection
KW  - Diagnosis
KW  - DNA probes
KW  - Infections
KW  - Laboratory animals
KW  - Plague
KW  - Techniques
KW  - vectors
KW  - Bacteria
KW  - Ceratophyllidae
KW  - Diamanus
KW  - Diamanus montanus
KW  - Mice
KW  - Oropsylla
KW  - Pulicidae
KW  - Siphonaptera
KW  - Xenopsylla cheopis
KW  - Yersinia pestis
KW  - prokaryotes
KW  - Siphonaptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Ceratophyllidae
KW  - Xenopsylla
KW  - Pulicidae
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - Diamanus
KW  - Oropsylla
KW  - bacterium
KW  - Oriental rat flea
KW  - Oropsylla montana
KW  - Thrassis bacchi
KW  - Yersinia pseudotuberculosis subsp. pestis
KW  - Techniques and Methodology (ZZ900) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Taxonomic clarification of Cladosporium trichoides Emmons and its subsequent synonyms.
AU  - Kwon-Chung, K. J.
AU  - Wickes, B. L.
AU  - Plaskowitz, J.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1989///
VL  - 27
IS  - 6
SP  - 413
EP  - 426
SN  - 0268-1218
AD  - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901205635.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A herbarium specimen of C. bantianum was compared with a herbarium specimen and a living type culture of C. trichoides by light and scanning electron microscopy (SEM) and was found to be dissimilar. Herbarium specimens and living cultures of Xylohypha nigrescens, the type species of the genus Xylohypha, were also compared with those of C. trichoides and other pathogenic Cladosporium spp. Fundamental differences were found between X. nigrescens and Cladosporium spp., in colony morphology, manner of sporulation and conidial morphology. All Cladosporium isolates produced olive-black colonies regardless of environmental conditions, bore brown pigment on the walls of the vegetative hyphae as well as on the walls of the fruiting structures and produced branched chains of conidia either from well differentiated or poorly differentiated conidiophores, or directly from the hyphae. By SEM, conidia showed strong to moderately protruded hila and the basal contour of the conidia was always truncated. On germination, hyphal tubes were produced randomly from the surface of the conidia. In contrast, X. nigrescens produced white colonies with or without brown centres, depending on the culture medium, bore pigment on the conidial walls and on conidiogenous cells but not on the vegetative hyphae and produced infrequently branched conidial chains, usually from intercalary conidiogenous cells which were globose to hat-shaped. Conidial hila were nonprotruding but, instead, were deeply concave and pore-like. The basal contour of the conidia was round and germ tubes were produced only from the pore-like hila. It is concluded that C. trichoides is different from C. bantianum and that the reclassification of C. trichoides into the genus Xylohypha was not warranted.
KW  - taxonomy
KW  - Cladophialophora bantiana
KW  - Cladophialophora
KW  - Herpotrichiellaceae
KW  - Chaetothyriales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Xylohypha
KW  - fungus
KW  - Hyphomycetes
KW  - systematics
KW  - Xylohypha bantiana
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205635&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Modified magnesium method in the aca III: elimination of interference by bilirubin.
AU  - Rehak, N. N.
AU  - Chiang, B. T.
JO  - Clinical Chemistry
JF  - Clinical Chemistry
Y1  - 1989///
VL  - 35
IS  - 6
SP  - 1031
EP  - 1033
SN  - 0009-9147
AD  - Rehak, N. N.: Warren Grant Magnuson Clinical Center, Clinical Chemistry Service, Clinical Pathology Department, National Institutes of Health, Building 10, Room 2C-407, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418735.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref. Registry Number: 7439-95-4.  Subject Subsets: Human Nutrition
N2  - Bilirubin interferes with the Du Pont magnesium method in the aca at 510 nm. It was determined that bilirubin concentrations in serum samples up to 380 mg/litre did not affect the absorbance measured in the aca III at 540 nm, and therefore the Du Pont setting of spectrophotometer for the Mg method was modified to 540 and 600 nm. Accuracy and precision of the modified method were similar to the unmodified method and to atomic absorption spectrophotometry. For comparison, 37 serum samples with normal and 22 with increased bilirubin concentration were analysed with the modified method in the aca III and in the atomic absorption spectrophotometer. The results (range 0.56 to 1.25 mmol/litre) were in good agreement and bilirubin did not interfere with the modified method.
KW  - blood
KW  - estimation
KW  - Magnesium
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418735&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clinical studies of Pneumocystis carinii and relationships to AIDS.
AU  - Masur, H.
JO  - Journal of Protozoology
JF  - Journal of Protozoology
Y1  - 1989///
VL  - 36
IS  - 1
SP  - 70
EP  - 74
AD  - Masur, H.: Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900859740.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 37 ref. Subject Subsets: Protozoology
N2  - The diagnosis, chemotherapy and prophylaxis of P. carinii infection in AIDS patients is discussed.
KW  - Acquired immune deficiency syndrome
KW  - diagnosis
KW  - DRUG THERAPY
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - prophylaxis
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - chemotherapy
KW  - fungus
KW  - general account
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900859740&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of antigens specific for Pneumocystis carinii.
AU  - Kovacs, J. A.
AU  - Lundgren, B.
AU  - Masur, H.
JO  - Journal of Protozoology
JF  - Journal of Protozoology
Y1  - 1989///
VL  - 36
SP  - 67S
EP  - 69S
AD  - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890859790.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 11 ref. Subject Subsets: Protozoology
N2  - Antigens specific for rat P. carinii and for human P. carinii were identified using polyclonal sera from immunized animals or from patients with P. carinii pneumonia. The most prominent bands seen in rat P. carinii preparations were an antigen of approximately 100 000 MW and a broad band ranging from 49-64 000 MW. The most prominent bands seen with the human P. carinii preparations included 2 bands of 22 and 24 000 MW and a broad band of 35-45 000 MW. Bands of 64, 75 and 100 000 MW were also seen. Sera obtained from 33 (human) adults were treated for P. carinii antibodies by immunoblotting. Antibodies were detected in 32 of 33 serum samples, including 7 from healthy people, 6 from patients with AIDS but no history of P. carinii pneumonia, and 10 from patients without AIDS but with a history of P. carinii pneumonia. Antibodies were detected in one of 8 children who were hospitalized for diarrhoea. Twenty of the 32 sera that contained antibodies against human P. carinii contained anti-rat P. carinii antibodies. It is suggested that rat and human strains of P. carinii are antigenically distinct. Five monoclonal antibodies specific for human P. carinii were produced. Two reacted with all human isolates tested, and none with rat isolates. Using an anti-rat P. carinii monoclonal antibody, 4 patterns of reactivity with immunoblot were seen. Antigens of 40, 50, 57, 85 and 100 000 MW were identified for rat P. carinii. Antibodies invariably reacted with more than one antigen. Using the anti-human P. carinii monoclonal antibodies, antigens of 22, 24, 65, 67 and 95 000 MW were seen. By immunoblot, only one monoclonal antibody, antibody 7D7, reacted with both rat and human P. carinii. This was the only antibody that reacted with both rat and human P. carinii by immunofluorescence. The monoclonal antibodies 7d7, 2G2 and 6B8 were found to identify 90% of patients with P. carinii when used in immunofluorescent assays.
KW  - antigens
KW  - Biotechnology
KW  - characterization
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - Laboratory animals
KW  - monoclonal antibodies
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Rodents
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - antigenicity
KW  - fungus
KW  - immunogens
KW  - rat strain differences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859790&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of rat liver microsomal and nuclear cytochrome P-450 by dietary 2-acetylaminofluorene and butylated hydroxytoluene.
AU  - Friedman, F. K.
AU  - Miller, H.
AU  - Park, S. S.
AU  - Graham, S. A.
AU  - Gelboin, H. V.
AU  - Carubelli, R.
JO  - Biochemical Pharmacology
JF  - Biochemical Pharmacology
Y1  - 1989///
VL  - 38
IS  - 18
SP  - 3075
EP  - 3081
SN  - 0006-2952
AD  - Friedman, F. K.: National Cancer Institute, Building 37, Room 3E24, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911430167.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 9035-51-2, 128-37-0.  Subject Subsets: Human Nutrition
N2  - The influence of dietary 2-acetylaminofluorene (AAF) on the cytochrome P-450 content of rat liver microsomal and nuclear fractions was immunochemically probed with monoclonal and polyclonal antibodies to cytochromes P-450c and P-450d. Cytochrome P-450d but not P-450c was immunodetected in microsomes, nuclear envelopes and nuclei from untreated rats. Values of cytochromes P-450c and P-450d were increased after a diet of 0.1% AAF for one week or 0.05% AAF for 3 weeks. Value of cytochrome P-450c relative to P-450d was lower after the more prolonged AAF feeding. Supplementation of AAF-containing diets with 0.3% butylated hydroxytoluene (BHT), which affords protection against AAF hepatocarcinogenesis in rats given diets high in fat, protected and/or induced total (spectral) nuclear envelope cytochrome P-450 content. Immunochemical studies of liver fractions showed that BHT enhanced the AAF-dependent induction of cytochrome P-450c, but not of P-450d. This was a concerted effect of AAF plus BHT since dietary BHT by itself did not affect the values of cytochrome P-450c or P-450d as compared with those in controls. Since 1- to 3-week dietary AAF had little effect on total (spectral analyses) microsomal cytochrome P-450 but reduced total P-450 in nuclear envelopes, the coordinated induction of specific cytochrome P-450s in the different fractions suggests selective induction and depression of different forms of cytochrome P-450 and provides additional evidence for independent regulation of the drug-metabolizing system in nuclear envelope and microsomes. The results suggest that regulation of cytochrome P-450 may play a crucial role in the nutritional modulation of AAF hepatocarcinogenesis.
KW  - butylated hydroxytoluene
KW  - Cytochrome P-450
KW  - induction
KW  - liver
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - acetylaminofluorene
KW  - BHT
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430167&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Persistance of hepatic fibrosis and tissue eggs following treatment of Schistosoma japonicum infected mice.
AU  - Cheever, A. W.
AU  - Deb, S.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1989///
VL  - 40
IS  - 6
SP  - 620
EP  - 628
SN  - 0002-9637
AD  - Cheever, A. W.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930804311.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 26328-53-0, 55268-74-1.  Subject Subsets: Helminthology
N2  - The persistence of hepatic fibrosis and of Schistosoma japonicum eggs in the tissues of mice was examined after chemotherapy. C57BL/6 mice infected with a Philippine strain of S. japonicum were tested with praziquantel or amoscanate 7 or 8 weeks after infection. Groups of mice were killed at the time of treatment and 3, 8, 26 and 52 weeks later. The number of eggs per worm pair in the tissues did not change during the year after treatment. However, S. japonicum eggs injected into the tail vein were gradually destroyed in the lungs. Hepatic fibrosis increased in the first few weeks after treatment and did not change significantly thereafter. Praziquantel, but not amoscanate, had an immediate toxic effect on the most mature eggs in the tissues which was accompanied by a marked but transient decrease in eggs passed in the faeces. Less mature eggs appeared unaffected by the drug and the passage of eggs in the faeces resumed as these matured. Egg passage then ceased as the supply of viable eggs was exhausted.
KW  - Amoscanate
KW  - Anthelmintics
KW  - drug therapy
KW  - Experimental infections
KW  - helminths
KW  - Human diseases
KW  - Laboratory animals
KW  - parasites
KW  - pathology
KW  - Praziquantel
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Rodents
KW  - Schistosoma japonicum
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - chemotherapy
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differential non-responsiveness in humans of candidate Plasmodium falciparum vaccine antigens.
AU  - Quakyi, I. A.
AU  - Otoo, L. N.
AU  - Pombo, D.
AU  - Sugars, L. Y.
AU  - Menon, A.
AU  - DeGroot, A. S.
AU  - Johnson, A.
AU  - Alling, D.
AU  - Miller, L. H.
AU  - Good, M. F.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1989///
VL  - 41
IS  - 2
SP  - 125
EP  - 134
SN  - 0002-9637
AD  - Quakyi, I. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900864587.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Protozoology
N2  - Using sera of 35 adults and 50 children from the The Gambia, West Africa, where P. falciparum is highly endemic, the humoral immune response to candidate malaria vaccine antigens from sporozoites, merozoites, and gametes was examined. Widespread restricted immunogenicity to defined parasite antigens was observed in children and adults. HLA typing of adult lymphocytes demonstrated a marked diversity in HLA haplotypes in this population. These results and those from previous studies in mice suggest that genetic factors may partly explain the immunological non-responsiveness. This may necessitate re-evaluation of the malaria vaccine strategy.
KW  - Human diseases
KW  - immune response
KW  - parasites
KW  - synthetic vaccines
KW  - Vaccines
KW  - Africa
KW  - Gambia
KW  - Apicomplexa
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - immunity reactions
KW  - immunological reactions
KW  - The Gambia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Filariasis now.
AU  - Ottesen, E. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1989///
VL  - 41
IS  - 3, II
SP  - 9
EP  - 17
SN  - 0002-9637
AD  - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900862776.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 37 ref. Subject Subsets: Helminthology
N2  - Progress made in lymphatic filariasis research with particular reference to immunology, immunopathology, immunoregulation and immunity is reviewed.
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - immunity
KW  - immunopathology
KW  - parasites
KW  - reviews
KW  - man
KW  - Nematoda
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - immunopathogenesis
KW  - nematodes
KW  - parasitic worms
KW  - Parasitology Then and Now
KW  - Paul C. Beaver Symposium
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of vitamin D deficiency on macrophage and lymphocyte function in the rat.
AU  - Wientroub, S.
AU  - Winter, C. C.
AU  - Wahl, S. M.
AU  - Wahl, L. M.
JO  - Calcified Tissue International
JF  - Calcified Tissue International
Y1  - 1989///
VL  - 44
IS  - 2
SP  - 125
EP  - 130
SN  - 0171-967X
AD  - Wientroub, S.: L.M. Wahl, Laboratory of Microbiology and Immunology, Building 30, Room 325, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901452891.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 67-97-0.  Subject Subsets: Human Nutrition
N2  - Rats deprived of cholecalciferol in utero and in postnatal life had significantly reduced thymocyte or splenocyte [³H]thymidine incorporation to mitogens and decreased macrophage chemotaxis when compared with cholecalciferol-sufficient rats. Secretion of soluble mediators, including interleukin 2 by lymphocytes and interleukin 1 and PGE2 by macrophages, was not affected by vitamin D deficiency.
KW  - Cholecalciferol
KW  - deficiency
KW  - lymphocytes
KW  - macrophages
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin D3
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452891&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relevance of basophil histamine release changes during venom immunotherapy.
AU  - Stephan, V.
AU  - Kühr, J.
AU  - Urbanek, R.
JO  - Allergy (Copenhagen)
JF  - Allergy (Copenhagen)
Y1  - 1989///
VL  - 44
IS  - 7
SP  - 453
EP  - 459
SN  - 0105-4538
AD  - Stephan, V.: National Institutes of Health, Bldg. 10 Rm 1A 23, 9000 Rockville Place, Bethesda, MD 20982, USA.
N1  - Accession Number: 19920500320.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 51-45-6.  Subject Subsets: Medical & Veterinary Entomology
N2  - The effect of rush and long-term venom immunotherapy on histamine release parameters in bee [Apis mellifera] venom allergic patients were investigated. 10 patients received rush venom immunotherapy, and histamine release data were obtained immediately before and after treatment. 17 patients were assessed by histamine release 24-63 months after termination of long-term venom immunotherapy. A control group of 10 non-allergic subjects was included in this study. Histamine released from whole blood was determined in a sensitive radio-enzymatic assay using a single isotope technique. Bee venom phospholipase A-induced histamine release from whole blood proved to be a test procedure of high specificity and sensitivity. 8 of 10 untreated patients and no control subjects showed significant antigen-induced histamine release. Results obtained from patients immediately after successful rush venom immunotherapy showed an important decrease (mean 45.9%) of total histamine content of basophils in all patients. Antigen-induced maximum histamine release was found to be increased in 1, decreased in 2 and unchanged in 7 patients. In patients who received long-term immunotherapy, cell sensitivity to phospholipase A was significantly lower than in a group of untreated patients. It is suggested that histamine depletion of basophils induced by rush immunotherapy may play an important role in patients' protection immediately after termination of the rush regimen.
KW  - Arthropod allergies
KW  - Basophils
KW  - Histamine
KW  - HONEY BEE VENOM
KW  - hypersensitivity
KW  - Immunotherapy
KW  - therapy
KW  - venoms
KW  - Apidae
KW  - Apis mellifera
KW  - Hymenoptera
KW  - man
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Apis
KW  - Apidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - allergic responses
KW  - honeybee venom
KW  - hypersensitiveness
KW  - therapeutics
KW  - venom
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Apiculture (LL010) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of caffeine on social behavior, exploration and locomotor activity: interactions with ethanol.
AU  - Hilakivi, L. A.
AU  - Durcan, M. J.
AU  - Lister, R. G.
JO  - Life Sciences
JF  - Life Sciences
Y1  - 1989///
VL  - 44
IS  - 8
SP  - 543
EP  - 553
SN  - 0024-3205
AD  - Hilakivi, L. A.: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Building 10 3C218, Bethesda, MD 20892, USA.
N1  - Accession Number: 19891416365.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 58-08-2, 64-17-5.  Subject Subsets: Human Nutrition
N2  - The effects of caffeine and its interaction with ethanol were examined in a test of social behaviour and a holeboard test of exploration and locomotion. Male mice were injected intraperitoneally with caffeine 15, 30 or 60 mg/kg alone or in combination with ethanol 2 g/kg. The mice were then put in pairs into a familiar arena, or examined individually in the holeboard. Only the highest dose of caffeine had a significant effect on the time spent in social interaction and motor activity in the social behaviour test: both measures were reduced. The duration and frequency of avoidance-irritability behaviour was dose-dependently increased by caffeine. In the holeboard, caffeine caused a dose-dependent increase in locomotor activity. Caffeine 30 mg/kg reversed the ethanol-induced reduction of time spent in social interaction, and 60 mg/kg antagonized the ethanol-induced increase in locomotor activity in the social behaviour and holeboard tests. The effects of caffeine on ethanol-induced behavioural changes are compared with those of other drugs.
KW  - activity
KW  - behaviour
KW  - Caffeine
KW  - ethanol
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - behavior
KW  - ethyl alcohol
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cell surface nanoanatomy of Leishmania major as revealed by fracture-flip. A surface meshwork of 44 nm fusiform filaments identifies infective developmental stage promastigotes.
AU  - Pimenta, P. F. P.
AU  - Silva, R. P. da
AU  - Sacks, D. L.
AU  - Silva, P. P. da
JO  - European Journal of Cell Biology
JF  - European Journal of Cell Biology
Y1  - 1989///
VL  - 48
IS  - 2
SP  - 180
EP  - 190
SN  - 0171-9335
AD  - Pimenta, P. F. P.: P.P. Da Silva, Building 538, Room 104, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD 21701, USA.
N1  - Accession Number: 19900860810.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Protozoology
N2  - Fracture-flip was used to reveal the nanoanatomy of the surface of L. major promastigotes. Over the cell surface of infective metacyclic promastigotes a meshwork of 44 nm long, fusiform filaments was identified. These filaments are not seen in non-infective stages of the parasite. Replica-staining immunocytochemistry with monoclonal antibody against infective metacyclic lipophosphoglycan shows a uniform distribution of protein A-colloidal gold complexes over the cell surface. Thin sections show that acquisition of the high molecular weight lipophosphoglycan is reflected in a thicker glycocalyx. Conventional freeze-fracture shows that, in infective metacyclic promastigotes, there is a reversal of the partition of intramembrane particles - an additional morphological marker for the infective developmental stage. It is hypothesized that the fusiform filaments represent metacyclic developmental lipophosphoglycan.
KW  - Human diseases
KW  - parasites
KW  - promastigotes
KW  - ultrastructure
KW  - Leishmania major
KW  - protozoa
KW  - Sarcomastigophora
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cell surface
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Oral contraceptives: effect of long-term use on liver vitamin A storage assessed by the relative dose response test.
AU  - Amatayakul, K.
AU  - Underwood, B. A.
AU  - Ruckphaopunt, S.
AU  - Singkamani, R.
AU  - Linpisarn, S.
AU  - Leelapat, P.
AU  - Thanangkul, O.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989///
VL  - 49
IS  - 5
SP  - 845
EP  - 848
SN  - 0002-9165
AD  - Amatayakul, K.: B.A. Underwood, National Eye Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901417207.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Vitamin A state estimated by the relative dose response (RDR) test was determined among groups of northern Thai women who had used oestrogen-containing oral contraceptives (OC) without or with multivitamin supplements during 13 cycles. Mean serum vitamin A values were 40% above those of control subjects (intrauterine contraceptive device users) during OC usage. Daily (one capsule) or periodic (2 capsules 7 days per month) multivitamin supplementation that included 1700 μg vitamin A per capsule did not significantly influence vitamin A serum values. The RDR test after 24 cycles was increased in one woman who had taken OC and the periodic multivitamin supplement. It reverted to normal after supplementation with vitamin A. A single high-dose vitamin A supplement (68 000 μg) did not change circulating values of the vitamin. Among this population there is little evidence that use of oestrogen-containing OC for more than 1 year resulted in a physiologically significant deterioration of vitamin A state.
KW  - liver
KW  - Oral contraceptives
KW  - retinol
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or β-carotene.
AU  - Luca, L. M. de
AU  - Shores, R. L.
AU  - Spangler, E. F.
AU  - Wenk, M. L.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1989///
VL  - 49
IS  - 19
SP  - 5400
EP  - 5406
SN  - 0008-5472
AD  - Luca, L. M. de: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Building 37, Room 3A-17, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911430031.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Vitamin A depletion was produced by giving female SENCAR mice a deficient diet at the birth of their young which were then weaned on the same diet. A single topical dose of 7,12-dimethylbenz(a)anthracene (DMBA) 20 µg was used as the initiator at 3 weeks of age and 12-O-tetradecanoylphorbol-13-acetate (TPA) 1 to 2 µg once weekly as the tumour promoter for 10 weeks (from week 4 to 13 of the experiment). 55% of mice (n = 40) on stock diet (mean body weight, 31.4 g) developed skin tumours (2.58 per mouse) at 12 weeks compared with 2.5% (0.05 papillomas per mouse) of mice (n = 40) kept on the purified vitamin A-deficient diet (mean body weight, 30.3 g), a 98% decrease in tumour/mouse. Retinoic acid (RA) (1-3 µg/g diet) supplementation after week 12 caused a rapid tumourigenic response in 95% of the mice by week 22. Even though tumour incidence increased within 1 week of RA and 95% of the mice showed the tumourigenic response, the number of tumours per mouse was about 50% of that observed in mice maintained on standard stock diet. It was concluded that physiological amounts of retinoids or their carotenoid precursor are necessary for DMBA-initiated, TPA-promoted tumour formation in the skin of female SENCAR mice.
KW  - Carcinoma
KW  - carotenoids
KW  - deficiency
KW  - retinol
KW  - skin
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - dermis
KW  - tetraterpenoids
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430031&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The cell surface of Trypanosoma cruzi: a fracture-flip, replica-staining label-fracture survey.
AU  - Pimenta, P. F. P.
AU  - Souza, W. de
AU  - Souto-Padrón, T.
AU  - Silva, P. P. da
JO  - European Journal of Cell Biology
JF  - European Journal of Cell Biology
Y1  - 1989///
VL  - 50
IS  - 2
SP  - 263
EP  - 271
SN  - 0171-9335
AD  - Pimenta, P. F. P.: P.P. da Silva, Membrane Biology Section, Laboratory of Mathematical Biology, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD 21701-1013, USA.
N1  - Accession Number: 19910869189.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Protozoology
N2  - Fracture-flip and replica-staining label-fracture were used to study the nanoanatomy and topochemistry of the cell surface of T. cruzi. Fracture-flip surface images differentiate the 3 main developmental stages of T. cruzi. Epimastigotes display a smooth surface, except the cytostome which appears as a clearly demarcated, raised, roughly textured platform. Amastigotes and trypomastigotes are covered by numerous surface particles with diameters ranging from 10 to 20 nm and 15 to 30 nm, respectively. Labelling of concanavalin A receptors showed that the surfaces of amastigotes and trypomastigotes were labelled, with amastigotes displaying the highest density of gold particles. In contrast, epimastigotes were sparsely labelled with exception of the cytostome, where a higher density of labelling coincided with the raised platform seen in fracture-flipped specimens, and with the particle-free area exposed on fracture faces. Labelling of epimastigotes by Ricinus communis I and Wistaria floribunda lectins showed that surface receptors for these lectins were absent from the cytostome.
KW  - Human diseases
KW  - parasites
KW  - ultrastructure
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - cell surface
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869189&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutritional factors in diabetics with and without retinopathy.
AU  - Roy, M. S.
AU  - Stables, G.
AU  - Collier, B.
AU  - Roy, A.
AU  - Bou, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989///
VL  - 50
IS  - 4
SP  - 728
EP  - 730
SN  - 0002-9165
AD  - Roy, M. S.: National Eye Institute, Building 10, Room 10C410, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418101.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - To examine nutritional factors in diabetic patients with and without retinopathy 3-day food records were used. Patients without retinopathy had significantly higher daily intakes of total carbohydrate, water-soluble dietary fibres, insoluble dietary fibres and glucose than did patients with retinopathy. Patients without retinopathy took a significantly lower proportion of their total daily energy as protein.
KW  - Diabetes
KW  - nutrition
KW  - retinopathy
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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ER  - 

TY  - JOUR
T1  - Issues in reproducibility and validity of dietary studies.
AU  - Block, G.
AU  - Hartman, A. M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989///
VL  - 50
SP  - 1133
EP  - 1138
SN  - 0002-9165
AD  - Block, G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Executive Plaza North, Room 313, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418368.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - Numerous factors affect the reproducibility and validity of dietary assessment questionnaires. Although the respondents' abilities to respond accurately are most frequently discussed as the cause of apparently poor reproducibility and validity, many other factors are as important and perhaps more important. Most of these other factors are under the control of the investigator and thus are amenable to improvement. Factors which may affect reproducibility include the degree of variability permitted by the instrument, the error-proneness of the response format, quality control of coding and keying, and real dietary change in the time between the 2 administrations of the questionnaire. Factors affecting real or apparent validity include respondent characteristics, questionnaire design and quantification, quality control, and the adequacy of the reference data. The implications of inadequate reference data are illustrated and discussed.
KW  - Diet study techniques
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Novel pyrrolidines in the venom of the ant Monomorium indicum.
AU  - Jones, T. H.
AU  - Blum, M. S.
AU  - Escoubas, P.
AU  - Ali, T. M. M.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1989///
VL  - 52
IS  - 4
SP  - 779
EP  - 784
SN  - 0163-3864
AD  - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910504362.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2  - New 2,5-dialkylpyrrolidines found in the venom of M. indicum (from Karnataka, India) include trans-2-butyl-5-(4-pentenyl)pyrrolidine, trans-2-butyl-5-(6-heptenyl)pyrrolidine, trans-5-(5-hexenyl)-2-(4-pentenyl)pyrrolidine, trans-5-(6-petenyl)-2-(5-hexenyl)pyrrolidine and trans-5-hepty-2-hexylpyrrolidine, whose structures were confirmed by synthesis. The concomitance of 5 previously reported trans-2,5-dialkyl-pyrrolidines along with small amounts of the cis isomers and N-methyl analogues makes the venom of M. indica the most qualitatively diverse blend of alkaloids reported from an ant to date. The toxicities to termites (Reticulitermes clavipes) of 4 of these alkaloids were determined.
KW  - agricultural entomology
KW  - Alkaloids
KW  - animal physiology
KW  - Biochemistry
KW  - Insect pests
KW  - pyrrolidine alkaloids
KW  - Toxicity
KW  - Toxins
KW  - venoms
KW  - India
KW  - Karnataka
KW  - arthropods
KW  - Formicidae
KW  - Hymenoptera
KW  - insects
KW  - Isoptera
KW  - Rhinotermitidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - Isoptera
KW  - Monomorium
KW  - Formicidae
KW  - Reticulitermes
KW  - Rhinotermitidae
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - Monomorium indicum
KW  - Mysore
KW  - pest insects
KW  - pyrrolidines
KW  - Reticulitermes clavipes
KW  - venom
KW  - Plant Composition (FF040) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Effects of magainins and cecropins on the sporogonic development of malaria parasites in mosquitoes.
AU  - Gwadz, R. W.
AU  - Kaslow, D.
AU  - Lee, J. Y.
AU  - Maloy, W. L.
AU  - Zasloff, M.
AU  - Miller, L. H.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1989///
VL  - 57
IS  - 9
SP  - 2628
EP  - 2633
SN  - 0019-9567
AD  - Gwadz, R. W.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900598634.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Agricultural Biotechnology
N2  - Magainins and cecropins are families of peptides with broad antimicrobial and antiparasitic activities derived respectively from the skin of frogs or from saturniid moths (Hyalophora cecropia). In insects, cecropins function as part of an inducible immune system against a number of bacterial infections. When injected into anopheline mosquitoes (Anopheles gambiae, A. dirus and/or A. freeborni) previously infected with a variety of Plasmodium species (P. cynomolgi, P. falciparum and/or P. knowlesi), both magainins and cecropins disrupt sporogonic development by aborting the normal development of oocytes; sporozoites are not formed and the vector cannot transmit the parasite to another host. It may be possible to induce effective transmission-blocking immunity in the mosquito vector by the introduction and expression of genes for magainins, cecropins or similarly acting parasiticidal peptides into the mosquito genome.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Magainins and cecropins are families of peptides with broad antimicrobial and antiparasitic activities derived respectively from the skin of frogs or from giant silk moths. In insects, cecropins function as part of an inducible immune system against a number of bacterial infections. When injected into anopheline mosquitoes previously infected with a variety of Plasmodium species, both magainins and cecropins disrupt sporogonic development by aborting the normal development of oocysts; sporozoites are not formed and the vector cannot transmit the parasite to another host. It may be possible to induce effective transmission-blocking immunity in the mosquito vector by the introduction and expression of genes coding for magainins, cecropins, or similarly acting parasiticidal peptides into the mosquito genome.AS.
KW  - Antibacterial agents
KW  - Biotechnology
KW  - development
KW  - Gene expression
KW  - Human diseases
KW  - Immune system
KW  - immunity
KW  - Infections
KW  - inhibition
KW  - Intermediate hosts
KW  - parasites
KW  - Transmission blocking immunity
KW  - vectors
KW  - Anopheles
KW  - Anopheles dirus
KW  - Anopheles freeborni
KW  - Anopheles gambiae
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Insects
KW  - Plasmodium
KW  - Plasmodium cynomolgi
KW  - Plasmodium falciparum
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Protozoa
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Cecropins
KW  - Magainins
KW  - mosquitoes
KW  - secondary hosts
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting.
AU  - Melby, P. C.
AU  - Sacks, D. L.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1989///
VL  - 57
IS  - 10
SP  - 2971
EP  - 2976
SN  - 0019-9567
AD  - Melby, P. C.: D. L. Sacks, Laboratory of Parasitic Diseases, Section of Immmunology and Cell Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900860295.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Protozoology
N2  - The generation of human T-lymphocyte clones derived from 2 patients with healed leishmaniasis (presumed to be Leishmania braziliensis and L. donovani) is described. By use of the one- and two-dimensional cellular immunoblotting techniques, the parasite antigens recognized by these clones were identified. These are thought to be the first leishmanial antigens identified to which CD4+, gamma interferon-producing T cells from immune individuals have been shown to respond.
KW  - antigens
KW  - Human diseases
KW  - parasites
KW  - T lymphocytes
KW  - Leishmania braziliensis
KW  - Leishmania donovani
KW  - protozoa
KW  - Sarcomastigophora
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - immunogens
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of regulatory elements of the equine infectious anemia virus and caprine arthritis-encephalitis virus long terminal repeats.
AU  - Sherman, L.
AU  - Yaniv, A.
AU  - Lichtman-Pleban, H.
AU  - Tronick, S. R.
AU  - Gazit, A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1989///
VL  - 63
IS  - 11
SP  - 4925
EP  - 4931
SN  - 0022-538X
AD  - Sherman, L.: S.R. Tronick, Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19902200068.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 9007-49-2.  Subject Subsets: Veterinary Science; Veterinary Science
N2  - The equine infectious anaemia virus (EIAV) long terminal repeat (LTR) was examined for sequences that influence its promoter activity and ability to be trans-activated by the EIAV tat gene product. A series of LTR deletion mutants and recombinants between LTR and simian virus 40 (SV 40) regulatory sequences were used for these studies. It was possible to identify the EIAV promoter region and sequences within the U3 region were shown to significantly inhibit LTR-directed transcription. However, when placed in a heterologous context (SV40 promoter) these U3 sequences functioned as an enhancer. Trans-activation of the EIAV LTR was found to depend upon sequences downstream of the transcription initiation site and also within U3. Deletion mutagenesis experiments showed that the major downstream element was present in a 46-nucleotide stretch (+4 to +50). An SV40 promoter construct containing these sequences could be trans-activated in cells expressing the EIAV tat gene product. For comparative purposes the LTR of another animal lentivirus, caprine arthritis-encephalitis virus (CAEV) were also examined for positive and negative transcriptional regulatory elements and demonstrated the presence of an enhancer within its U3 sequence. There is evidence that trans-activation of the CAEV LTR requires U3 sequences. When the EIAV U3 region was replaced by the CAEV U3 sequence, the promoter activity of the EIAV LTR was markedly increased, but responsiveness tothe EIAV trans-activator could not be restored.
KW  - Biotechnology
KW  - cat diseases
KW  - DNA
KW  - Gene expression
KW  - horse diseases
KW  - Molecular biology
KW  - Nucleotides
KW  - Strain differences
KW  - viral diseases
KW  - Caprine arthritis encephalitis virus
KW  - cats
KW  - equine infectious anemia virus
KW  - horses
KW  - Lentivirus
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Equus
KW  - Equidae
KW  - Perissodactyla
KW  - deoxyribonucleic acid
KW  - Equine infectious anaemia virus
KW  - Lentivirinae
KW  - viral infections
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - The effect on fetal growth of protozoan and helminthic infection during pregnancy.
AU  - Villar, J.
AU  - Klebanoff, M.
AU  - Kestler, E.
JO  - Obstetrics and Gynecology (New York)
JF  - Obstetrics and Gynecology (New York)
Y1  - 1989///
VL  - 74
IS  - 6
SP  - 915
EP  - 920
SN  - 0029-7844
AD  - Villar, J.: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Executive Plaza North, Room 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900864989.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Helminthology; Protozoology
N2  - A prospective study of 14 914 pregnant women was conducted in Guatemala City, Guatemala. Stool samples were obtained from the women before the first prenatal visit (mean gestational age 21.6 weeks) for the diagnosis of parasitic infections during pregnancy. 44% harboured at least one parasite, and 24% were infected with helminths. Ascaris lumbricoides was the most prevalent (14.5%). Infected mothers were less educated, had less adequate water and sanitary conditions, and had lower nutritional status than uninfected women. The incidence of intrauterine growth retardation (IUGR) increased with the number of parasite species detected (up to 2 or more species). High levels of infection were associated with an increased risk of IUGR for protozoa and helminths, except for Strongyloides stercoralis and Hymenolepis nana. Chronically malnourished women (of short stature) had significantly higher IUGR rates when infected with one or 2 or more species; parasitic infection did not affect IUGR in women taller than 1.47 m. It is concluded that up to 10% of the IUGR rates may be attributed to parasitic infections in malnourished women.
KW  - Females
KW  - fetal growth
KW  - helminths
KW  - Human diseases
KW  - Parasites
KW  - pathology
KW  - pregnancy
KW  - Central America
KW  - Guatemala
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - America
KW  - CACM
KW  - Central America
KW  - Developing Countries
KW  - Latin America
KW  - foetal growth
KW  - gestation
KW  - parasitic worms
KW  - prevalence
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans.
AU  - Goldstein, D. S.
AU  - Stull, R.
AU  - Eisenhofer, G.
AU  - Gill, J. R., Jr.
JO  - Clinical Science
JF  - Clinical Science
Y1  - 1989///
VL  - 76
IS  - 5
SP  - 517
EP  - 522
SN  - 0143-5221
AD  - Goldstein, D. S.: Building 10, Room 7N238, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901451245.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 63-84-5, 51-61-6, 7440-23-5.  Subject Subsets: Human Nutrition
N2  - Daily excretion of dihydroxyphenylalanine (dopa) and dopamine (DA) was assessed in 10 normal adults on a constant diet during 1 week of normal sodium intake (109 mmol daily), 1 week of low Na intake (9 mmol daily) and 1 week of high Na intake (249 mmol daily). Urinary DA excretion exceeded urinary dopa excretion about 10-fold. The excretion of DA and dopa about doubled between the low- and high-salt diets. Plasma dopa was unchanged by dietary salt manipulation. Results indicate that dopa may function indirectly as a neurohormone in homeostatic regulation of Na balance.
KW  - Dopa
KW  - Dopamine
KW  - intake
KW  - sodium
KW  - urine
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dioxyphenylalanine
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lymphocyte subpopulations in bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.
AU  - Lal, R. B.
AU  - Kumaraswami, V.
AU  - Krishnan, N.
AU  - Nutman, T. B.
AU  - Ottesen, E. A.
JO  - Clinical and Experimental Immunology
JF  - Clinical and Experimental Immunology
Y1  - 1989///
VL  - 77
IS  - 1
SP  - 77
EP  - 82
SN  - 0009-9104
AD  - Lal, R. B.: E. Ottesen, Building 4, Room 126, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910866544.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - To examine the relationship between lymphocyte phenotypes and states of activation in patients with bancroftian filariasis, dual colour flow cytometry and concurrent in vitro cell culture were performed on normal individuals (NV; n=15), and on patients with either asymptomatic microfilaraemia (MF; n=12) or elephantiasis (CP; n=11). In contrast to findings by others in a population with brugian filariasis, the percentages of total B lymphocytes (CD19), T lymphocytes (CD3), helper/inducer T lymphocytes (CD4), and suppressor/cytotoxic T lymphocytes (CD8) in both patient groups were found to be within the range defined by clinically normal individuals. Furthermore, there were no differences among the groups in the expression of the IL-2 receptor (CD25) on T cells. There was, however, a significantly greater proportion of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 ± 8.6%) than in the MF (8.9 ± 2.6%) or NV (8.3 ± 2.9%) groups. Further, when the expression of this activation antigen was examined in parallel with in vitro mitogen responsiveness, an inverse correlation between the percentage of CD8+ HLA-DR+ lymphocytes and pokeweed mitogen-induced proliferation was seen. These data provide further definition of the immunoregulatory abnormalities seen in human filarial infections and suggest that activated CD8+ T lymphocytes may be involved in the pathogenesis of the chronic obstructed lymphatic form of this disease.
KW  - bancroftian filariasis
KW  - filariids
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - immunology
KW  - parasites
KW  - Pathogenesis
KW  - T lymphocytes
KW  - Brugia malayi
KW  - Brugia timori
KW  - man
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Wuchereria
KW  - immunity reactions
KW  - immunological reactions
KW  - lymphocyte phenotypes
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Fluoridation then and now.
AU  - Corbin, S. B.
T2  - American Journal of Public Health
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989///
VL  - 79
IS  - 5
SP  - 561
EP  - 563
SN  - 0090-0036
AD  - Corbin, S. B.: Disease Prevention Policy Analyst, National Institutes of Health, National Institute of Dental Research, Westwood Building, Room 538, 5333 Westbard Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911453833.  Publication Type: Editorial.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - The positive contribution of fluoridated drinking water to community health is discussed. Studies beginning with the successful two-city trial in the USA in 1945 are highlighted.
KW  - Drinking water
KW  - fluoridation
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Is alcohol consumption related to breast cancer? Results from the Framingham Heart Study.
AU  - Schatzkin, A.
AU  - Carter, C. L.
AU  - Green, S. B.
AU  - Kreger, B. E.
AU  - Splansky, G. L.
AU  - Anderson, K. M.
AU  - Helsel, W. E.
AU  - Kannel, W. B.
JO  - Journal of National Cancer Institute
JF  - Journal of National Cancer Institute
Y1  - 1989///
VL  - 81
IS  - 1
SP  - 31
EP  - 35
AD  - Schatzkin, A.: Executive Plaza North, Rm. 211J, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901450991.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Human Nutrition
N2  - A total of 2636 women 31 to 64 years old, in the Framingham Heart Study cohort in Massachusetts, USA, provided information on alcohol consumption at the second biennial examination. During a 32-year follow-up, breast cancer was diagnosed in 143 women. Alcohol intake was also assessed at 10 and 20 years of follow-up and every 2 years thereafter. In analyses using only baseline alcohol intake, the multiple risk factor-adjusted relative risk (RR) estimate of breast cancer for any drinking, compared with non-drinking, was 0.8 [95% confidence interval (CI) 0.5 to 1.1]. For 3 levels of alcohol intake (0.1 to 1.4, 1.5 to 4.9 and 5.0 g or more daily), the baseline analyses yielded RRs (compared with non-drinking) of 1.0 (CI 0.6 to 1.5), 0.7 (CI 0.4 to 1.1) and 0.6 (CI 0.4 to 1.0), respectively. In analyses incorporating repeated measures of alcohol, the comparable RRs were 0.9 (CI 0.6 to 1.2) for any drinking (compared with non-drinking) and 0.7 (CI 0.4 to 1.4), 1.1 (CI 0.7 to 1.8) and 0.8 (CI 0.5 to 1.2), respectively, for the 3 levels of intake (compared with non-drinking). Results indicate that alcohol consumption was not associated with an increased risk of breast cancer in this cohort.
KW  - alcohols
KW  - Carcinoma
KW  - mammary glands
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Myosin I heavy-chain genes of Acanthamoeba castellanii: cloning of a second gene and evidence for the existence of a third isoform.
AU  - Jung, G.
AU  - Schmidt, C. J.
AU  - Hammer, J. A., III
JO  - Gene
JF  - Gene
Y1  - 1989///
VL  - 82
IS  - 2
SP  - 269
EP  - 280
SN  - 0378-1119
AD  - Jung, G.: J.A. Hammer, National Institutes of Health, National Heart, Lung and Blood Institute, Building 3, Room B1-22, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890859708.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology
N2  - The complete sequence and structure of a myosin I heavy-chain gene (MIL) from A. castellanii was determined. This gene spans ~ 6 kb, is split by 17 introns, encodes a 1147-amino acid polypeptide, and is transcribed in log-phase cells. The positions of 6 of the introns are conserved relative to a vertebrate muscle myosin gene. Similar to the previously characterized MIB heavy-chain gene, the deduced MIL heavy-chain amino acid sequence revealed a 125 000 MW protein composed of a myosin globular head domain joined to a novel, ~ 50 000 MW C-terminal domain rich in glycine, proline and alanine residues. There were differences between MIL and MIB in the sequence organization of their unconventional C-terminal domains. It is concluded from this and other data that Acanthamoeba express at least 3 myosin I heavy-chain isoforms: MIL, MIA and MIB. Amoeba genomic DNA blots probed with a short, highly conserved sequence whose position is transposed between MIB and MIL indicated that the Acanthamoeba myosin I heavy-chain gene family may contain 6 genes. The myosin I sequences were compared with those of Drosophila NinaC and the bovine myosin I-like protein, and it was found that a portion of the unconventional C-terminal domains of the amoeba myosins I and the bovine protein appear to be related.
KW  - genes
KW  - Human diseases
KW  - molecular genetics
KW  - myosins
KW  - parasites
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting.
AU  - Melby, P. C.
AU  - Neva, F. A.
AU  - Sacks, D. L.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1989///
VL  - 83
IS  - 6
SP  - 1868
EP  - 1875
SN  - 0021-9738
AD  - Melby, P. C.: D. L. Sacks, Building 5, Room 112, National Institute of Health, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19890859153.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology
N2  - The pattern of peripheral blood lymphocyte responses was determined in patients with active, healed, or subclinical Leishmania infection to fractionated leishmanial antigens using a T cell immunoblotting method in which nitrocellulose-bound leishmanial antigens, resolved by one or two dimensional electrophoresis, are incorporated into lymphocyte cultures. The proliferative and interferon-γ responses of cells from patients with healed mucosal or cutaneous leishmaniasis were remarkably heterogenous and occurred to as many as 50-70 distinct antigens. In contrast, responses from subjects with active, nonhealing, diffuse cutaneous leishmaniasis were either absent or present to only a small number of antigens. This indicates that control and resolution of leishmaniasis, and resistance to reinfection is associated with a T cell response to a large and diverse pool of parasite antigens. T cell immunoblotting appears to be an appropriate method for the identification of antigens involved in eliciting a T cell response in human leishmaniasis.
KW  - antigens
KW  - characterization
KW  - Human diseases
KW  - immunoblotting
KW  - parasites
KW  - T lymphocytes
KW  - Leishmania
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - immunogens
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.
AU  - Lowe, W. L., Jr.
AU  - Adamo, M.
AU  - Werner, H.
AU  - Roberts, C. T., Jr.
AU  - LeRoith, D.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1989///
VL  - 84
IS  - 2
SP  - 619
EP  - 626
SN  - 0021-9738
AD  - Lowe, W. L., Jr.: D. LeRoith, Building 10, Room 8S243, Diabetes Branch, NIDDK Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19891421824.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9038-70-4.  Subject Subsets: Human Nutrition
N2  - In rats which were deprived of food for 48 h total insulin-like growth factor I (IGF-I) mRNA values decreased by about 80% in lung and liver, about 60% in kidney and muscle, and only about 30 to 40% in stomach, brain and testes. In heart, IGF-I mRNA values did not change. The amounts of the different splicing variants of the primary IGF-I transcript, were essentially coordinately regulated within a given tissue. Specific [125I]IGF-I binding in lung, testes, stomach, kidney and heart was increased by food deprivation by about 30 to 100%, whereas in brain [125I]IGF-I binding did not change in response to deprivation. In tissues in which deprivation increased IGF-I receptor number, receptor mRNA values increased about 1.6- to 2.5-fold, whereas when IGF-I receptor number was unchanged in response to deprivation, receptor mRNA values did not change.
KW  - Somatomedin
KW  - starvation
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - insulin-like growth factor 1
KW  - sulfation factor
KW  - sulphation factor
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prospective study of the standard meal provocative test in Zollinger-Ellison syndrome.
AU  - Frucht, H.
AU  - Howard, J. M.
AU  - Stark, H. A.
AU  - McCarthy, D. M.
AU  - Maton, P. N.
AU  - Gardner, J. D.
AU  - Jensen, R. T.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1989///
VL  - 87
SP  - 528
EP  - 536
SN  - 0002-9343
AD  - Frucht, H.: R.T. Jensen, National Institutes of Health, Building 10, Room 9C-103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901419990.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Human Nutrition
N2  - The proposed usefulness of a standard meal-stimulated gastrin provocative test was studied in: distinguishing Zollinger-Ellison syndrome (ZES) from antral syndromes; localizing duodenal gastrinomas; or suggesting that patients with multiple endocrine neoplasia type I (MEN-I) may have an increased incidence of antral syndromes. A total of 74 consecutive patients with ZES were studied prospectively. The extent and location of gastrinomas, acid secretory studies and the presence or absence of MEN-I were noted and correlated with the results of the gastrin response to standard meal provocative testing. Of 43 patients with fasting serum gastrin concentrations less than 1000 pg/ml, only 19 had a less than 50% increase over the premeal value, which is reported to be the typical response in ZES, and 17 had a 50 to 99% increase; 7 had a 100% or greater increase, 4 a 150% or greater increase, and 2 a 200% or greater increase, which overlaps with values reported to be characteristic of 98, 92 and 46% of patients with antral syndromes. Results did not differ for patients with or without MEN-I, depend on the extent of the gastrinoma (duodenal versus pancreatic gastrinomas), the presence of previous gastric surgery or type of gastric surgery or for patients with fasting serum gastrin concentrations 1000 or more or for those with less than 1000 pg/ml. Studies of 4 patients before and after resection of the gastrinoma, who before surgery had a greater than 100% increase in gastrin secretion after the meal, showed that all patients had a less than 100% increase after surgery even though no gastric resection was done.
KW  - tests
KW  - Zollinger-Ellison syndrome
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419990&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Establishing an enteral product formulary.
AU  - Ford, D. B.
AU  - Bergerson, S. L.
AU  - Henderson, P.
AU  - Murphy, J. A.
AU  - Peter, J.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1989///
VL  - 89
IS  - 5
SP  - 681
EP  - 683
SN  - 0002-8223
AD  - Ford, D. B.: Nutrition Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921441014.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Human Nutrition
N2  - At the Clinical Center, National Institutes of Health, Bethesda, MD, USA, the nutrition department created a formula management committee, which developed a system that aligned formula product selection with the enteral needs of the patients, provided an ongoing system of formula management, and provided extensive education to dietitians on product formulation. The formula system involved categories of products to be considered and criteria for product selection, identification of enteral needs of patients in the institution, review of current literature on formulation of all major enteral products, and taste evaluation of products to be used orally. Composition of the formula was then determined, and interdepartmental efforts for implementation were coordinated. The overall impact included a 37% reduction in variety of products stocked, the creation of an annual update system, and extensive dietetic education on product formulation and usage. The direct impact on patient care was the provision of formula specifically targeted to meet the enteral needs of patients at nutritional risk within the institution.
KW  - Enteral feeding
KW  - formulations
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrient intake recommendations needed for the older American.
AU  - Andres, R.
AU  - Hallfrisch, J.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1989///
VL  - 89
IS  - 12
SP  - 1739
EP  - 1741
SN  - 0002-8223
AD  - Andres, R.: Gerontology Research Center, Metabolism Section, Laboratory of Clinical Physiology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
N1  - Accession Number: 19901451896.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Subject Subsets: Human Nutrition
N2  - Dietary needs and habits of the elderly in the USA are discussed. Until recently little attention was paid to dietary needs of the elderly and what recommendations there were were largely based on extrapolations of studies made with young subjects, usually men. Recent studies indicate that requirements for several nutrients may be different for older and younger adults and for older men and older women.
KW  - nutrient requirements
KW  - Old age
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - dietary standards
KW  - food requirements
KW  - nutritional requirements
KW  - United States of America
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of duck hepatitis B virus replication by 2′,3′-dideoxycytidine. A potent inhibitor of reverse transcriptase.
AU  - Kassianides, C.
AU  - Hoofnagle, J. H.
AU  - Miller, R. H.
AU  - Doo, E.
AU  - Ford, H.
AU  - Broder, S.
AU  - Mitsuya, H.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1989///
VL  - 97
IS  - 5
SP  - 1275
EP  - 1280
SN  - 0016-5085
AD  - Kassianides, C.: Liver Diseases Section, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19902206630.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 7841-89-2.  Subject Subsets: Veterinary Science; Veterinary Science; Poultry; Public Health
N2  - The effect of the antiviral 2′,3′-dideoxycytidine (DDC) was assessed both in vitro and in vivo against chronic infections of duck hepatitis B virus (DHBV) in 18 Pekin ducks; to see whether it could inhibit reverse transcriptase in view of the fact that human HBV belong to the hepadnaviruses, which contain reverse transcriptase. Over 6 days 9 ducks were given 11 mg/m² of DDC i.v. every 6 hours, 2 ducks were given 1000 and 400 mg/m² of adenine arabinoside monophosphate (Ara-AMP) i.m. twice daily and 7 ducks received no treatment. Blood samples from the wing vein were analysed for serum DHBV deoxyribonucleic acid (DNA) polymerase activity using autoradiography, and samples from liver biopsies were examined by light microscopy. Plasma levels of DDC as determined by high performance liquid chromatography, had an estimated peak of 60 µM. Serum DHBV DNA and DNA polymerase activity decreased in every duck treated with DDC. The mean inhibition of DNA polymerase and duck hepatitis B virus DNA on the third day of treatment with DDC was 64% and 73%, respectively. Four ducks continued to show &gt;50% inhibition 12 days after stopping treatment (inhibition of DNA polymerase on day 18 was 55%). The decrease in DNA levels was greater with Ara-AMP, there was a decrease of 71% with the low dose and 86% with the high dose. DHBV DNA which was measured in total cellular DNA extracted from liver biopsy specimens obtained before and on the last day of treatment with DDC showed an average inhibition of 96% in 3 ducks treated with DDC but showed no decrease in the remaining 5 ducks. It was concluded that DDC has potent antiviral activity against DHBV and potential use against chronic hepatitis B infection in humans.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors report reduction in levels of duck hepatitis B DNA and polymerase activity of about two thirds in chronically infected ducks by the nucleoside analogue dideoxycytidine. These markers began to rise after cessation of therapy but not as rapidly as with other antiviral agents. [This drug is already in Phase II trials against HIV infection].D.W. FitzSimons
KW  - Antiviral agents
KW  - dideoxycytidine
KW  - Hepatitis B
KW  - poultry
KW  - treatment
KW  - Viral diseases
KW  - duck hepatitis virus
KW  - Ducks
KW  - Hepadnaviridae
KW  - Hepatitis B virus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Anatidae
KW  - Anseriformes
KW  - birds
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - DNA Reverse Transcribing Viruses
KW  - Hepadnaviridae
KW  - 2',3'-dideoxycytidine
KW  - dideoxycytidine inhibition
KW  - domesticated birds
KW  - viral infections
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmania mexicana mexicana: quantitative analysis of the intracellular cycle.
AU  - Doyle, P. S.
AU  - Engel, J. C.
AU  - Gam, A. A.
AU  - Dvorak, J. A.
JO  - Parasitology
JF  - Parasitology
Y1  - 1989///
VL  - 99
IS  - 3
SP  - 311
EP  - 316
SN  - 0031-1820
AD  - Doyle, P. S.: J.A. Dvorak, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA.
N1  - Accession Number: 19900862739.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The complete intracellular cycle of the L. m. mexicana G. S. strain was quantified in human macrophages and in the mouse IC-21 macrophage line using a culture system that allows the direct observation of individual intracellular parasites. A wide range of pre-replicative lag periods was found, implying that promastigotes may be in any phase of their DNA synthetic cycle when phagocytosed by the macrophage. Amastigotes replicated 2-3 times, after which the host cell died and liberated amastigotes that were taken up by other macrophages and continued to replicate. The mean amastigote population-doubling time in human macrophages (17.5 h) was not statistically different from promastigotes growing in axenic culture (16.4 h), but was nearly 2-fold less than amastigotes growing in mouse-derived IC-21 macrophages (33.7 h). These observations were markedly different to the results of the cover-glass culture assays of Leishmania-macrophage interactions, but it is concluded that the direct observation of amastigotes in the kinetic studies allowed an unambiguous description of the intracellular cycle of L. m. mexicana.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The complete intracellular cycle of the Leishmania mexicana mexicana G.S. strain was quantified in human macrophages and in the mouse IC-21 macrophage line utilizing a culture system that allows the direct observation of individual intracellular parasites. A wide range of pre-replicative lag periods exists, implying that promastigotes may be in any phase of their DNA synthetic cycle when phagocytosed by the macrophage. Amastigotes replicated 2-3 times, after which the host cell died and liberated amastigotes that were taken up by other macrophages and continued to replicate. The mean amastigote population-doubling time in human macrophages (17.5 h) was not statistically different from promastigotes growing in axenic culture (16.4 h), but was nearly 2-fold less than amastigotes growing in mouse-derived IC-21 macrophages (33.7 h). These observations are markedly different from cover-glass culture assays of Leishmania-macrophage interactions and provide an unambiguous description of the intracellular cycle of Leishmania mexicana mexicana.AS
KW  - development
KW  - Human diseases
KW  - in vitro
KW  - macrophages
KW  - parasites
KW  - Leishmania mexicana
KW  - protozoa
KW  - Sarcomastigophora
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania mexicana
KW  - intracellular cycle kinetics
KW  - Kinetoplastorida
KW  - Leishmania mexicana mexicana
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma membrane association of Acanthamoeba myosin I.
AU  - Miyata, H.
AU  - Bowers, B.
AU  - Korn, E. D.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1989///
VL  - 109
SP  - 1519
EP  - 1528
SN  - 0021-9525
AD  - Miyata, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808686.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9064-37-3. 
KW  - Actin
KW  - Human diseases
KW  - myosins
KW  - Plasma membranes
KW  - Proteins
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cell membrane
KW  - myosin
KW  - plasmalemma
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808686&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis pneumonia: from bench to clinic.
AU  - Masur, H.
AU  - Lane, H. C.
AU  - Kovacs, J. A.
AU  - Allegra, C. J.
AU  - Edman, J. C.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1989///
VL  - 111
IS  - 10
SP  - 813
EP  - 826
SN  - 0003-4819
AD  - Masur, H.: National Institutes of Health, Clinical Center, Critical Care Medicine, Room 10D48, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861748.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 93 ref. Subject Subsets: Protozoology
N2  - This review article is an edited summary of a Clinical Staff Conference sponsored by the National Institutes of Health, US Department of Health and Human Sciences held in November 1988, at Bethesda, Maryland, USA. Recent advances in the knowledge of P. carinii pneumonia are discussed under the headings: immunologic bases for susceptibility; immunologic studies - epidemiologic and diagnostic implications; metabolic studies - therapeutic implications; the current approach to therapy and prophylaxis; molecular biology - future effects on taxonomy, diagnosis and therapy.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - clinical aspects
KW  - HIV infections
KW  - Human diseases
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - reviews
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861748&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induced sputum to diagnose Pneumocystis carinii pneumonia in immunosuppressed pediatric patients.
AU  - Ognibene, F. P.
AU  - Gill, V. J.
AU  - Pizzo, P. A.
AU  - Kovacs, J. A.
AU  - Godwin, C.
AU  - Suffredini, A. F.
AU  - Shelhamer, J. H.
AU  - Parrillo, J. E.
AU  - Masur, H.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1989///
VL  - 115
IS  - 3
SP  - 430
EP  - 433
SN  - 0022-3476
AD  - Ognibene, F. P.: Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900862575.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology
N2  - Sputum induction with an ultrasonic nebulizer was used for the diagnosis of 20 episodes of clinical pneumonia that developed in 18 immunosuppressed children (mean age 7.3 years). Nine episodes of P. carinii pneumonia were documented in 8 children, 6 of whom were HIV positive. All 9 sputum specimens were positive by IFAT, and 8 were positive by toluidine blue staining. Five bronchoscopy procedures on 4 patients whose sputum was negative for P. carinii did not reveal P. carinii. Two patients with negative sputum showed clinical improvement after empirical treatment with trimethoprim sulfamethoxazole. Four sputum-negative patients who did not receive empirical treatment also improved clinically. All children tolerated ultrasonic nebulization; nausea and vomiting were the only side effects. It is concluded that sputum induction often provides a pulmonary specimen sufficient to diagnose P. carinii pneumonia.
KW  - children
KW  - clinical aspects
KW  - diagnosis
KW  - HIV infections
KW  - Human diseases
KW  - immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - sputum induction
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus infections
KW  - Induced sputum
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862575&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A dietary and risk factor questionnaire and analysis system for personal computers.
AU  - Smucker, R.
AU  - Block, G.
AU  - Coyle, L.
AU  - Harvin, A.
AU  - Kessler, L.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1989///
VL  - 129
IS  - 2
SP  - 445
EP  - 449
SN  - 0002-9262
AD  - Smucker, R.: G. Block, Executive Plaza North, Room 313, Division of Cancer Prevention and Control, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901419506.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Subject Subsets: Human Nutrition
N2  - The adaptation of a dietary and risk factor questionnaire and analysis system for use with IBM (or compatible) personal computers is reported. This system includes a flexible computer-assisted interview program which may be modified to suit investigator needs while preserving a standard output format. It also includes a nutrient analysis program for calculation of usual dietary intake. Each of these two major components has its own set of utilities and options, so that investigators may tailor the system to particular research areas. The nature and capabilities of the two main programs are described, as well as the development of the underlying system and the general flow of data in the system.
KW  - Diet study techniques
KW  - epidemiology
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxoplasma gondii: Mechanism of resistance to complement-mediated killing.
AU  - Fuhrman, S. A.
AU  - Joiner, K. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1989///
VL  - 142
IS  - 3
SP  - 940
EP  - 947
SN  - 0022-1767
AD  - Fuhrman, S. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873350.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9007-36-7.  Subject Subsets: Protozoology
N2  - Tachyzoites of T. gondii are resistant to lysis in non-immune human serum. An examination of the mechanism of this serum resistance in RH and P strain organisms, which differ markedly in virulence, but are equally resistant to serum killing, is reported. Rapid, but limited, activation of the alternative complement pathway occurred in non-immune human serum, with deposition of equivalent amounts of C3 on the 2 strains. C3 bound covalently to parasite acceptor molecules via an ester linkage. The predominant form of C3 was iC3b which cannot participate in formation of a lytic C5b-9 complex. Multiple membrane constituents of the tachyzoite of T. gondii may serve as acceptors for the limited amount of C3 deposited during incubation in non-immune serum. When tachyzoites were pre-sensitized with the lytic anti-p30 MAb 7B8, new amide-linked C3-acceptor complexes formed. Nearly equivalent C3 binding but a 3-fold enhancement of 125I-C9 binding occurred when MAb 7B8 pre-sensitized tachyzoites were compared to native organisms. These results indicate that tachyzoites of T. gondii are serum resistant because of failure to activate C efficiently. Pre-sensitization with a lytic MAb alters the site of complement deposition and augments C5b-9 formation.
KW  - complement
KW  - Human diseases
KW  - immune response
KW  - in vitro
KW  - parasites
KW  - tachyzoites
KW  - Apicomplexa
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei.
AU  - Kumar, S.
AU  - Good, M. F.
AU  - Dontfraid, F.
AU  - Vinetz, J. M.
AU  - Miller, L. H.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1989///
VL  - 143
IS  - 6
SP  - 2017
EP  - 2023
SN  - 0022-1767
AD  - Kumar, S.: L.H. Miller, Laboratory of Parasitic Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900864337.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Protozoology
N2  - Pooled serum from BALB/c mice immunized against P. vinckei transferred limited protection to BALB/c mice and no protection to athymic nu/nu mice. In vivo depletion of CD4+ T cells in immune mice abrogated their immunity but this could be reversed through reconstitution of CD4-depleted mice with fractionated B-, CD8-, CD4+ immune spleen cells; however adoptive transfer of fractionated CD4+ T cells from immune spleen to naive BALB/c or histocompatible BALB/c nude mice did not render the recipients immune. In vivo depletion of CD8+ T cells did not influence parasitaemia in non-immune or immune mice. Splenectomy of immune mice completely reversed their immunity. Repletion of splenectomized mice with their own spleen cells did not reconstitute their immunity. The results suggest that some feature of the malaria-modified spleen acts in concert with the effector/inducer function of CD4+ T cells to provide protection against P. vinckei and that a malaria vaccine may require a combination of Plasmodium antigen to induce immune CD4+ T cells and an adjuvant to alter the spleen.
KW  - Disease models
KW  - immunity
KW  - Laboratory animals
KW  - parasites
KW  - spleen
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium vinckei
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - CD4+ T lymphocytes
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.
AU  - James, S. L.
AU  - Glaven, J.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1989///
VL  - 143
IS  - 12
SP  - 4208
EP  - 4212
SN  - 0022-1767
AD  - James, S. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910868018.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Helminthology
N2  - Lymphokine (LK)-activated macrophages are cytotoxic for multicellular larvae of S. mansoni. Macrophage-mediated larval killing was found to be arginine dependent, as indicated by inhibition in the presence of exogenous arginase or the competitive inhibitor NG-monomethyl-L-arginine. Culture supernatant fluids from the larvicidal LK-activated macrophages contained nitrite, a product of activated macrophages derived by oxidation of arginine and implicated in the antitumour and antimicrobial effector function of these cells. Nitrite was not detectable in supernatant fluids obtained from nonactivated macrophages or from macrophages stimulated with LK in the presence of arginase or NG-monomethyl-L-arginine. Addition of excess iron or the reductant sodium dithionite to LK-activated macrophage cultures also inhibited larval killing in vitro, under conditions that have been shown by others to stabilize the activity of iron-containing enzymes involved in respiration. Nitrite production was not decreased under these conditions. These observations are consistent with the hypothesis that macrophage-mediated schistosomulum killing is caused, at least in part, by a mechanism proposed for tumour cytotoxicity, whereby production of reactive nitrogen intermediates triggers iron loss from critical target cell enzymes leading to lethal metabolic inhibition. Schistosomula were shown to be killed by inhibitors of mitochondrial respiration.
KW  - cytotoxicity
KW  - Developmental stages
KW  - helminths
KW  - Human diseases
KW  - Lymphokines
KW  - macrophages
KW  - parasites
KW  - schistosomula
KW  - Digenea
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - growth phase
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910868018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The place of HDL in cholesterol management. A perspective from the National Cholesterol Education Program.
AU  - Grundy, S. M.
AU  - Goodman, D. S.
AU  - Rifkind, B. M.
AU  - Cleeman, J. I.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1989///
VL  - 149
IS  - 3
SP  - 505
EP  - 510
SN  - 0003-9926
AD  - Grundy, S. M.: J.I. Cleeman, National Cholesterol Education Program, Office of Prevention, Education, and Control, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901417538.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The guidelines developed by the Adult Treatment Panel of the USA National Cholesterol Education Program identified low-density lipoprotein (LDL) as the main atherogenic lipoprotein and high values of LDL cholesterol as the primary target for treatment to lower cholesterol. Low values of high-density lipoprotein (HDL) cholesterol were recognized as a risk factor for coronary heart disease. This report re-examines in depth the recommendations of the Adult Treatment Panel on HDL cholesterol. Questions are discussed. Should HDL cholesterol values be estimated in all adults, as recommended for total cholesterol and should patients found to have a low serum LDL cholesterol (less than 35 mg/100 ml or less than 0.91 mmol/litre) start medical treatment to increase the value? The guidelines of the Adult Treatment Panel are reaffirmed as appropriate from the current perspective. These guidelines recommend that HDL cholesterol values be estimated in patients deemed to be at high risk for coronary heart disease and suggest that HDL estimation is optimum for persons with borderline-high total values. The guidelines of the Adult Treatment Panel recommended that low HDL cholesterol values be raised mainly by hygienic means (i.e., smoking cessation, weight loss, aerobic exercise). When drug treatment is required for high LDL cholesterol values in the presence of low HDL values, cholesterol-lowering drugs that concomitantly increase HDL should be given first priority.
KW  - cholesterol
KW  - heart diseases
KW  - High density lipoprotein
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - coronary diseases
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Is coffee consumption a contributor to cardiovascular disease? Insights from the Framingham Study.
AU  - Wilson, P. W. F.
AU  - Garrison, R. J.
AU  - Kannel, W. B.
AU  - McGee, D. L.
AU  - Castelli, W. P.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1989///
VL  - 149
IS  - 5
SP  - 1169
EP  - 1172
SN  - 0003-9926
AD  - Wilson, P. W. F.: Framingham Study, National Heart, Lung, and Blood Institute, 118 Lincoln St, Framingham, MA 01701, USA.
N1  - Accession Number: 19901417821.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Human Nutrition
N2  - Reported coffee consumption during 1954 to 1958 and 1971 to 1973 was used to test for association with cardiovascular disease (CVD) incidence and lipid values in the Framingham (Massachusetts, USA) Study. Multivariate analysis was employed, regressing CVD on age, systolic pressure, cigarette use, body mass index, total cholesterol and coffee intake. In pooled analyses (2648 men with 549 CVD cases and 3566 women with 462 CVD cases) coffee intake was not associated with CVD incidence in smokers or non-smokers, irrespective of sex. Similarly, multivariate analyses for persons with existing CVD showed no association between coffee intake and subsequent CVD. In men significant negative associations between coffee and total cholesterol, and very-low-density lipoprotein cholesterol were seen, whereas in women positive associations with low-density lipoprotein cholesterol were observed. Although inconsistent effects on the lipid profile were seen, no increase in primary or secondary CVD was seen with coffee drinking.
KW  - cardiovascular diseases
KW  - Coffee
KW  - Massachusetts
KW  - USA
KW  - Coffea
KW  - Man
KW  - Rubiaceae
KW  - Rubiales
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Monoclonal antibodies to Pneumocystis carinii: identification of specific antigens and characterization of antigenic differences between rat and human isolates.
AU  - Kovacs, J. A.
AU  - Halpern, J. L.
AU  - Lundgren, B.
AU  - Swan, J. C.
AU  - Parrillo, J. E.
AU  - Masur, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1989///
VL  - 159
IS  - 1
SP  - 60
EP  - 70
SN  - 0022-1899
AD  - Kovacs, J. A.: Critical Care Medicine Department, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900860528.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Protozoology
N2  - Monoclonal antibodies to rat and human P. carinii were developed, and their specificity was demonstrated by immunofluorescence and immunoblot studies. Only one of 5 monoclonal antibodies to rat P. carinii reacted with human P. carinii, and none of 4 monoclonal antibodies to human P. carinii reacted with rat P. carinii. Two antibodies to human P. carinii reacted by immunofluorescence with only one human P. carinii isolate; the other 2 reacted with all 16 isolates. Immunoblot studies identified major antigens of rat P. carinii with MWs of 40 000-100 000 and of human P. carinii with MWs of 22 000-95 000. These studies provide evidence of significant antigenic differences between rat and human P. carinii and are consistent with the suggestion that individual isolates of human P. carinii are also antigenically different.
KW  - antigens
KW  - Human diseases
KW  - monoclonal antibodies
KW  - Opportunistic infections
KW  - parasites
KW  - strain differences
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - antigenicity
KW  - fungus
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents.
AU  - Kovacs, J. A.
AU  - Allegra, C. J.
AU  - Beaver, J.
AU  - Boarman, D.
AU  - Lewis, M.
AU  - Parrillo, J. E.
AU  - Chabner, B.
AU  - Masur, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1989///
VL  - 160
IS  - 2
SP  - 312
EP  - 320
SN  - 0022-1899
AD  - Kovacs, J. A.: Critical Care Medicine Department, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900867791.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 59-30-3.  Subject Subsets: Protozoology
N2  - Drug therapy studies imply that P. carinii and T. gondii possess the enzymes necessary for de novo folate synthesis. To verify this, incorporation of [³H]paraaminobenzoic acid ([³H]PABA) into reduced folates of P. carinii and T. gondii was investigated. Both parasites synthesized tritiated reduced folates. In P. carinii, 10-formyltetrahydrofolate and tetrahydrofolate, and in T. gondii, 5-formyltetrahydrofolate were the major synthesized folates. P. carinii remained metabolically active in vitro for only a few days. Because current systems for screening anti-Pneumocystis agents are cumbersome, the utility of this assay system for screening therapeutic agents was investigated. Sulfonamides and pentamidine efficiently inhibited de novo folate synthesis in P. carinii. Inhibitors of dihydrofolate reductase such as trimethoprim and trimetrexate were poor inhibitors for P. carinii but efficient inhibitors for T. gondii. This study demonstrates the first unambiguous evidence of metabolic activity in P. carinii, and provides a potential assay for efficiently screening anti-Pneumocystis drugs in vitro.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antiinfective agents
KW  - antiprotozoal agents
KW  - Biochemistry
KW  - drugs
KW  - folic acid
KW  - Human diseases
KW  - Inhibitors
KW  - Metabolism
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - screening
KW  - synthesis
KW  - Techniques
KW  - testing
KW  - Apicomplexa
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - AIDS
KW  - antimicrobials
KW  - folacin
KW  - folate
KW  - folates
KW  - fungus
KW  - medicines
KW  - pharmaceuticals
KW  - screening tests
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Health Services (UU350) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prophylaxis of Pneumocystis carinii pneumonia: an update.
AU  - Kovacs, J. A.
AU  - Masur, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1989///
VL  - 160
IS  - 5
SP  - 882
EP  - 886
SN  - 0022-1899
AD  - Kovacs, J. A.: Bldg.10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910881486.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Protozoology
N2  - The prophylaxis of P. carinii pneumonia is discussed under the following headings: who should receive prophylaxis?; does treatment with zidovudine eliminate the need for specific antipneumocystis prophylaxis?; is prophylaxis effective in HIV-infected patients?; what are the risks of prophylaxis?; how should P. carinii prophylaxis be managed in HIV-infected patients?
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antiprotozoal agents
KW  - HIV infections
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - prophylaxis
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - discussion
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910881486&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A specific and sensitive assay for the Lyme disease spirochete Borrelia burgdorferi using the polymerase chain reaction.
AU  - Rosa, P. A.
AU  - Schwan, T. G.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1989///
VL  - 160
IS  - 6
SP  - 1018
EP  - 1029
SN  - 0022-1899
AD  - Rosa, P. A.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19900501393.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - A highly specific and sensitive assay for B. burgdorferi, the causative agent of Lyme disease, was developed using the polymerase chain reaction (PCR). The target DNA sequence was of chromosomal origin and conserved, by hybridization analyses, among all strains of B. burgdorferi tested but was not present in the most closely related member of the genus, B. hermsii. The PCR assay developed from this sequence reacted with 17 of 18 strains of B. burgdorferi but not with any other Borrelia species tested. The assay was sensitive to fewer than 5 copies of the B. burgdorferi genome, even in the presence of a 106-fold excess of eukaryotic DNA. This assay should greatly facilitate the accurate diagnosis of Lyme disease and provide a means with which to investigate the pathogenesis, transmission and basic biology of B. burgdorferi.
KW  - assays
KW  - Biochemical techniques
KW  - detection
KW  - Diagnosis
KW  - Diagnostic techniques
KW  - DNA
KW  - Lyme disease
KW  - polymerase chain reaction
KW  - Tickborne diseases
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - lyme borreliosis
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Impaired production of nerve growth factor in the submandibular gland of diabetic mice.
AU  - Kasayama, S.
AU  - Oka, T.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1989///
VL  - 257
IS  - 3,I
SP  - E400
EP  - E404
SN  - 0002-9513
AD  - Kasayama, S.: T. Oka, Building 8, Room 304, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418704.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - The production of nerve growth factor (NGF) in submandibular glands was examined in 2 kinds of diabetic mice. In genetically diabetic (C57BL/KsJ db/db) mice, which show marked insulin resistance and hyperglycaemia, the concentration of NGF in the submandibular gland was less than one-tenth that of the non-diabetic controls. In streptozotocin-induced diabetic C57BL/KsJ mice, which show pancreatic insulitis leading to insulin deficiency and hyperglycaemia, the glandular NGF concentration fell in a time-dependent manner to 26% of control value at 5 weeks after the streptozotocin injection. Insulin given daily to the streptozotocin-induced diabetic mice restored the NGF concentration to almost the control value. The molecular size of NGF (13 kdalton) in the glandular extracts of the genetically diabetic (db/db) mice in Western blots was indistinguishable from that of the control mice, but its amount was reduced in the glands of the diabetic (db/db) mice. Although plasma NGF concentrations were normally below the sensitivity of the assay (less than 0.80 ng/ml) in control and diabetic (db/db) mice, administration of cycloytidine, which stimulates NGF release from the submandibular gland into the blood circulation, increased plasma NGF to 5.95 ng/ml in controls, but did not do so in the diabetic (db/db) mice.
KW  - Diabetes
KW  - growth
KW  - neurons
KW  - polypeptides
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - nerve cells
KW  - neurones
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human selenite metabolism: a kinetic model.
AU  - Patterson, B. H.
AU  - Levander, O. A.
AU  - Helzlsouer, K.
AU  - McAdam, P. A.
AU  - Lewis, S. A.
AU  - Taylor, P. R.
AU  - Veillon, C.
AU  - Zech, L. A.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1989///
VL  - 257
IS  - 3,II
SP  - R556
EP  - R567
SN  - 0002-9513
AD  - Patterson, B. H.: Executive Plaza North, Room 344, Biometry Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901418871.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
N2  - A model was developed to describe the kinetics of sodium selenite metabolism, based on plasma, urine and faecal samples obtained from 3 men and 3 women during 4 weeks after a single oral dose of 200 μg of enriched stable isotope tracer 74Se. The model describes absorption, distributed along the gastrointestinal tract and enterohepatic recirculation. The model includes 4 kinetically distinct plasma components, a subsystem consisting of the liver and pancreas, and a slowly turning-over tissue pool. For the 6 subjects, the ranges of mean residence times for the 4 plasma components were, respectively, 0.2 to 1.1, 3 to 8, 9 to 42 and 200 to 285 h; for the hepatopancreatic subsystem 4 to 41 days; and for the tissue pool 115 to 285 days. About 84% of the dose was absorbed and after 12 days about 65% remained in the body. The model predicts that after 90 days about 35% of this Se would be retained, primarily in the tissues. Separating Se metabolism into several distinct kinetic components is a first step in identifying the efficacious, nutritious and toxic forms of the element.
KW  - metabolism
KW  - Selenium
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418871&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The dietary fat-breast cancer hypothesis is alive.
AU  - Schatzkin, A.
AU  - Greenwald, P.
AU  - Byar, D. P.
AU  - Clifford, C. K.
JO  - Journal of the American Medical Association
JF  - Journal of the American Medical Association
Y1  - 1989///
VL  - 261
IS  - 22
SP  - 3284
EP  - 3287
AD  - Schatzkin, A.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20892, USA.
N1  - Accession Number: 19891416908.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - Data from animal experiments and human correlation studies strongly support the dietary fat/breast cancer hypothesis and it is suggested that a causal relation between dietary fat and breast malignancy is biologically plausible. Negative findings from recent analytical epidemiological studies of dietary fat and breast cancer indicated that the hypothesis is no longer viable but it is argued that only limited conclusions should be drawn from epidemiological studies to date because of the narrow range of dietary fat intake among subjects and the substantial measurement error in dietary assessment. It is proposed that intensive efforts at designing better studies of the hypothesis are needed, including laboratory investigations in man that examine possible mechanisms for the effects of fat; large, prospective epidemiological studies; and randomized, controlled diet trials.
KW  - Carcinoma
KW  - fats
KW  - mammary glands
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification and characterization of a third isoform of myosin I from Acanthamoeba castellanii.
AU  - Lynch, T. J.
AU  - Brzeska, H.
AU  - Miyata, H.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1989///
VL  - 264
IS  - 32
SP  - 19333
EP  - 19339
SN  - 0021-9258
AD  - Lynch, T. J.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861070.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Protozoology
N2  - A third isoform of myosin I was isolated from A. castellanii and designated myosin IC. Peptide maps and immunoassays indicated that myosin IC is not a modified form of myosin IA, IB, or II. However, myosin IC has most of the distinctive properties of a myosin I. It is a globular protein of native MW ~ 162 000, apparently composed of a single 130 000 MW heavy chain and a pair of 14 000 MW light chains. It is soluble in MgATP at low ionic strength, conditions favouring filament assembly by myosin II. Myosin IC has high Ca2+- and (K+,EDTA)-ATPase activities. Its low Mg2+ -ATPase activity is stimulated to a maximum rate of 20/s by the addition of F-actin if its heavy chain has been phosphorylated by myosin I heavy chain kinase. The dependence of the Mg2+-ATPase activity of myosin IC on F-actin concentration is triphasic, and, at fixed concentrations of F-actin, this activity increases cooperatively as the concentration of myosin IC is increased. Myosin IC is capable of cross-linking F-actin, which, together with the kinetics of its actin-activated Mg2+-ATPase activity, suggests that it, like myosins IA and IB, possesses 2 independent actin-binding domains.
KW  - biochemistry
KW  - Human diseases
KW  - myosins
KW  - parasites
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861070&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The localization and sequence of the phosphorylation sites of Acanthamoeba myosins I. An improved method for locating the phosphorylated amino acid.
AU  - Brzeska, H.
AU  - Lynch, T. J.
AU  - Martin, B.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1989///
VL  - 264
IS  - 32
SP  - 19340
EP  - 19348
SN  - 0021-9258
AD  - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900861071.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activities of Acanthamoeba myosins IA, IB, and IC are expressed only when a single site in their heavy chains is phosphorylated by a myosin I heavy chain-specific kinase. It is shown that phosphorylation occurs at Ser-315 in the myosin IB heavy chain, Ser-311 in myosin IC, and a threonine residue at a corresponding position in myosin IA (whose amino acid sequence is as yet unknown). The most obvious feature common to the 3 substrates is a basic amino acid 2 or 3 residues before the site of phosphorylation. The phosphorylation site is located between the ATP- and actin-binding sites, which corresponds to the middle of the 50 000 MW domain of skeletal muscle myosin subfragment 1. The sequence similarity between the region surrounding the phosphorylation site of myosin I and subfragment 1 is much lower than the average sequence similarity between myosin I and subfragment 1. This is consistent with the hypothesis that the conformation of this region of myosin I differs from that of the corresponding region in skeletal muscle myosin and that phosphorylation converts the conformation of the actomyosin I complex into a conformation comparable to that present in actosubfragment 1 without phosphorylation. The protein sequences obtained suggest that the myosin I genes previously identified as myosin IB and IL (myosin-like) heavy chains actually are the myosin IC and IB heavy chains, respectively. A modification of the method for monitoring the appearance of 32Pi during sequencing of 32P-labelled peptides that results in almost complete recovery of the radioactivity, thus allowing unequivocal assignment of the position of the phosphorylated residue, is described.
KW  - biochemistry
KW  - Human diseases
KW  - myosins
KW  - parasites
KW  - proteins
KW  - Acanthamoeba
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - phosphorylation sites
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861071&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The modification of diet in renal disease study.
AU  - Klahr, S.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1989///
VL  - 320
IS  - 13
SP  - 864
EP  - 866
SN  - 0028-4793
AD  - Klahr, S.: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901420014.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
N2  - Progress is reported on the Modification of Diet in Renal Disease study which is a multicentre cooperative study set up in the USA by the recommendations of the National Institute of Diabetes and Digestive and Kidney Diseases to define the influence of the dietary restriction of protein and phosphorus on the progression of chronic renal disease.
KW  - diet treatment
KW  - Kidney diseases
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - diet prescription
KW  - kidney disorders
KW  - nephropathy
KW  - renal diseases
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901420014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Developmental regulation of stage-specific ribosome populations in Plasmodium.
AU  - Waters, A. P.
AU  - Syin, C.
AU  - McCutchan, T. F.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1989///
VL  - 342
IS  - 6248
SP  - 438
EP  - 440
SN  - 0028-0836
AD  - Waters, A. P.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, Building 4, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900865069.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Protozoology
N2  - The switch from the A gene (that yields transcripts predominant in the asexual blood stage) to the C gene (mainly transcribed in the sporozoite developing in the mosquito) was studied in P. falciparum. The switch from A to C gene expression involved the control of rRNA processing, allowing accumulation of precursor C-gene transcripts in gametocytes. These precursor molecules are processed to mature size in the zygote and the early ookinete, where both transcription and processing of the C-gene rRNA seem to be accelerated. As the C-gene precursor rRNA appears, a defined and limited pattern of breakdown of the dominant A-gene RNA occurs, in which conserved, functionally active sequences involved in the termination of translation and elongation are targeted. By the late oocyst stage, the A-gene transcripts are virtually replaced by mature C-gene transcripts.
KW  - development
KW  - Human diseases
KW  - molecular genetics
KW  - parasites
KW  - ribosomes
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Strategies for malaria control: realities, magic and science.
AU  - Miller, L. H.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1989///
VL  - 569
SP  - 118
EP  - 126
SN  - 0077-8923
AD  - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900866382.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 35 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Methods for malaria eradication and control are discussed under the headings: research on the Anopheles vector; chemotherapy research, research towards malaria vaccines. The interactions between discoveries in the laboratory, and their impact in the field, are emphasized.
KW  - control
KW  - disease vectors
KW  - Human diseases
KW  - Intermediate hosts
KW  - Malaria
KW  - Mosquito-borne diseases
KW  - parasites
KW  - Vectors
KW  - Anopheles
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Insects
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - discussion
KW  - mosquitoes
KW  - secondary hosts
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An overview of the modification of diet in renal disease study.
AU  - Kusek, J. W.
AU  - Caggiula, A. W.
AU  - Williams, G. W.
AU  - Klahr, S.
JO  - Contributions to Nephrology
JF  - Contributions to Nephrology
Y1  - 1989///
IS  - 81
SP  - 50
EP  - 60
SN  - 0302-5144
AD  - Kusek, J. W.: Division of Kidney, Urologic and Hematologic Diseases, National Institutes of Health, Room 621, Westwood Building, 5333 Westbard Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921439805.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Human Nutrition
N2  - To test the effects of intervention(s) on the rate of progression of chronic renal disease, in a controlled clinical trial, the National Institutes of Health in USA, in collaboration with the Health Care Financing Administration, initiated the Modification of Diet in Renal Disease (MDRD) Study. The study is being carried out in four phases: protocol development (phase 1); pilot study (phase 2); full-scale study (phase 3), and data analysis and dissemination of results (phase 4). The purpose and design of the pilot investigation is briefly reviewed and an overview of the full-scale study is presented.
KW  - diet studies
KW  - Renal failure
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - kidney failure
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Structural features of Borrelia burgdorferi - the Lyme disease spirochete: silver staining for nucleic acids.
AU  - Garon, C. F.
AU  - Dorward, D. W.
AU  - Corwin, M. D.
JO  - Scanning Microscopy
JF  - Scanning Microscopy
Y1  - 1989///
SP  - 109
EP  - 115
SN  - 0891-7035
AD  - Garon, C. F.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19910503520.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia burgdorferi was grown in a modified Kelly medium and characterized by transmission and scanning electron microscopy. Using silver staining procedures which preferentially bind to nuclear components of eukaryotic cells, signal could be detected by back-scattered electron imaging throughout the length of the spirochaete. Interestingly, however, the highest levels of back-scattered signal were observed in naturally elaborated membrane blebs that were attached to cell surfaces and free in the medium. These membranes vesicles could be enriched by filtration through nitrocellulose or Anopore membranes and by differential centrifugation. The possibility of contaminating cellular DNA coating the membrane vesicles was ruled out by exhaustive digestion with pancreatic DNAase I. Intact DNA was demonstrated both by lysing blebs directly on the surface of microscope grids and by extracting molecules from purified bleb preparation with detergents and solvents. Both linear and circular DNA molecules could be identified in purified membrane blebs. A simple, one-step, alternative silver staining procedure is described which appears to effectively label the protein-nucleic acid complexes contained in the membrane vesicles of B. burgdorferi.
KW  - DNA
KW  - electron microscopy
KW  - Scanning electron microscopy
KW  - staining
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Fungal infections in granulocytopenic patients: current approaches to classification, diagnosis, and treatment.
AU  - Walsh, T. J.
AU  - Pizzo, P. A.
A2  - Holmberg, K.
A2  - Meyer, R.D.
T2  - Diagnosis and therapy of systemic fungal infections.
JO  - Diagnosis and therapy of systemic fungal infections.
JF  - Diagnosis and therapy of systemic fungal infections.
Y1  - 1989///
SP  - 47
EP  - 70
CY  - New York; USA
PB  - Raven Press
SN  - 0881675539
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19901205605.  Publication Type: Miscellaneous.  Language: English.  Number of References: 108 ref. Registry Number: 86386-73-4, 84625-61-6, 91161-71-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - Aspects of host defence against fungi relevant to granulocytopenic patients are discussed and nosocomial infections of such patients are defined and classified. The clinical manifestations and treatment of mycoses in granulocytopenic patients, including those caused by Aspergillus, Pseudallescheria boydii, Fusarium, Candida, Trichosporon beigelii, plus phycomycoses and chromomycoses, are reviewed. The current status of antifungal agents, such as itraconazole, fluconazole and terbinafine, is also considered.
KW  - Antifungal agents
KW  - Fluconazole
KW  - infections
KW  - Itraconazole
KW  - Mycoses
KW  - phaeohyphomycosis
KW  - predisposition
KW  - Reviews
KW  - Terbinafine
KW  - therapy
KW  - zygomycosis
KW  - Aspergillus
KW  - Candida
KW  - Fusarium
KW  - Man
KW  - Pseudallescheria boydii
KW  - Trichosporon beigelii
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - chromomycosis
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - phycomycosis
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205605&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Essential obesity and the pathogenetic role of a low metabolic rate.
AU  - Bogardus, C.
AU  - Ravussin, E.
A2  - Halsted, C.H.
A2  - Rucker, R.B.
T2  - Nutrition and the origins of disease.
JO  - Nutrition and the origins of disease.
JF  - Nutrition and the origins of disease.
Y1  - 1989///
SP  - 145
EP  - 160
CY  - San Diego, CA; USA
PB  - Academic Press, Inc.
SN  - 012319640X
AD  - Bogardus, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19901452138.  Publication Type: Conference paper.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - Obesity is a familial and, to a significant extent, a genetic disorder caused by an excess of energy intake over expenditure. Accurate methods to assess the impact of disorders of feeding behaviour and appetite regulation on the imbalance in this energy equation are currently unavailable. However, studies of energy expenditure among the Pima Indians have shown that rates of energy expenditure vary more among individuals than can be accounted for by differences in body size, age or sex; rates of energy expenditure aggregate in families, independently of these covariates; low rate of energy expenditure is associated with an increased risk of weight gain. These data suggest that a low metabolic rate contributes to the familial aggregation of obesity. It seems evident that there is such a concept as "essential obesity". Research is urgently needed to develop new pharmacological agents to treat this disorder that is associated with significant morbidity and mortality.
KW  - energy exchange
KW  - metabolism
KW  - Obesity
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - Nutrition and the Origins of Disease
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452138&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Role of gastrointestinal hormones in adaptation.
AU  - Go, V. L. W.
A2  - Halsted, C.H.
A2  - Rucker, R.B.
T2  - Nutrition and the origins of disease.
JO  - Nutrition and the origins of disease.
JF  - Nutrition and the origins of disease.
Y1  - 1989///
SP  - 321
EP  - 331
CY  - San Diego, CA; USA
PB  - Academic Press, Inc.
SN  - 012319640X
AD  - Go, V. L. W.: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19901452154.  Publication Type: Conference paper.  Language: English.  Number of References: 31 ref. Subject Subsets: Human Nutrition
N2  - The gastrointestinal neuroendocrine system plays an important role in the nutritional adaptation that takes place from the prenatal to the postnatal stages of development. Nutrients can regulate the secretion of gastrointestinal hormones and regulatory peptides, each of which has a unique regional distribution in both gut and neural tissues. Hormones and peptides including gastrin, secretin, cholecystokinin, gastric inhibitory polypeptide, motilin, human pancreatic polypeptide, enteroglucagon, neurotensin and the colon hormone peptide YY control the gut functions that are essential in converting food into absorbable nutrients and in the metabolic processes required for growth, development and survival. Carbohydrates, proteins and fats have different specificities and potencies in regulating secretion of different gut hormones and peptides, some of which exhibit trophic effects. The chronic release of a gut hormone or peptide in response to stimulation by a particular nutrient could result in adaptation in organ function but the cellular mechanisms involved in these processes remain to be elucidated.
KW  - Gastrointestinal hormones
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - gastric hormones
KW  - Nutrition and the Origins of Disease
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452154&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Immunochemical characterization of the Leishmania donovani 3′-nucleotidase.
AU  - Pastakia, K. B.
AU  - Dwyer, D. M.
A2  - D.T. Hart
T2  - Leishmaniasis: The current status and new strategies for control. Proceedings of a NATO Advanced Study Institute on leishmaniasis: The first centenary (1885-1985), new strategies for control, Zakinthos, Greece, 20-27 September, 1987.
Y1  - 1989///
CY  - New York; USA
PB  - Plenum Press
SN  - 0306431467
AD  - Pastakia, K. B.: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900863489.  Publication Type: Book chapter; Conference paper.  Language: English.  Number of References: 6 ref. Registry Number: 9033-33-4.  Subject Subsets: Protozoology
KW  - biochemistry
KW  - enzymes
KW  - Human diseases
KW  - nucleotidase
KW  - parasites
KW  - promastigotes
KW  - Leishmania
KW  - Leishmania donovani
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - current status and new strategies for control
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863489&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Toxoplasmosis in patients with the acquired immunodeficiency syndrome.
AU  - Kovacs, J. A.
T2  - Opportunistic infections in patients with the acquired immunodeficiency syndrome.
Y1  - 1989///
CY  - New York; USA
PB  - Marcel Dekker, Inc.
SN  - 0824780809
AD  - Kovacs, J. A.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19900864986.  Publication Type: Book chapter.  Language: English.  Number of References: 35 ref. Subject Subsets: Protozoology
N2  - A brief account of the life cycle of Toxoplasma gondii, the epidemiology and clinical manifestations of toxoplasmosis in the immunocompetent host, is followed by a review of its epidemiology and clinical manifestations in patients with AIDS, histopathology, laboratory evaluation, diagnosis, differential diagnosis and therapy.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - AIDS
KW  - general account
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864986&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The compromised host: AIDS and other diseases.
AU  - Masur, H.
A2  - Walzer, P. D.
A2  - Genta, R. M.
T2  - Parasitic infections in the compromised host.
Y1  - 1989///
CY  - New York; USA
PB  - Marcel Dekker Inc.
SN  - 0834779436
AD  - Masur, H.: Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19890859355.  Publication Type: Book chapter.  Language: English.  Number of References: 76 ref. Subject Subsets: Helminthology; Protozoology
N2  - Defence mechanisms in healthy humans, and immune disorders which compromise the host are considered. Protozoal and helminth infections in compromised patients and parasitic infections in AIDS patients are discussed.
KW  - helminths
KW  - Human diseases
KW  - immunocompromised hosts
KW  - Opportunistic infections
KW  - Parasites
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - discussed
KW  - parasitic infections in compromised hosts
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859355&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The host immune responses against parasitic helminth infection.
AU  - Nutman, T. B.
A2  - Walzer, P. D.
A2  - Genta, R. M.
T2  - Parasitic infections in the compromised host.
Y1  - 1989///
CY  - New York; USA
PB  - Marcel Dekker Inc.
AD  - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19890859375.  Publication Type: Book chapter.  Language: English.  Number of References: 130 ref. Subject Subsets: Helminthology
N2  - The immune response of humans to helminth infection is considered under the headings: the parasites; genetic and environmental determinants of susceptibility to infection; evasion of the immune response by the parasites; immunological consequences of parasitic infection; unique factors of the immune responses to helminth parasites; effector mechanisms mediating host immunity to helminth parasites.
KW  - Helminths
KW  - Human diseases
KW  - immune response
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - general account
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic infections in compromised hosts
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859375&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Giardia lamblia.
AU  - Smith, P. D.
A2  - Walzer, P. D.
A2  - Genta, R. M.
T2  - Parasitic infections in the compromised host.
Y1  - 1989///
CY  - New York; USA
PB  - Marcel Dekker Inc.
SN  - 0824779436
AD  - Smith, P. D.: Laboratory of Immunology, NIDR, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19890859373.  Publication Type: Book chapter.  Language: English.  Number of References: 248 ref. Subject Subsets: Protozoology
N2  - G. lamblia infection in man is discussed under the headings: the organism (life cycle and epidemiology, growth and metabolism, antigenic components and virulence); the host (host defence mechanisms, pathogenesis, pathology); the disease (clinical features, diagnosis, treatment and prevention).
KW  - Human diseases
KW  - Opportunistic infections
KW  - parasites
KW  - Giardia duodenalis
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - general account
KW  - Giardia lamblia
KW  - Immunocomprised hosts
KW  - parasitic infections in compromised hosts
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859373&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Parasitic diseases.
AU  - Román, G. C.
JO  - Foundations of Neurology
JF  - Foundations of Neurology
Y1  - 1990///
VL  - 1
SP  - 407
EP  - 424
AD  - Román, G. C.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874472.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Protozoology; Helminthology
N2  - The recent advances in the treatment of cerebral malaria and neurocysticercosis are discussed. Topics covered include: clinical aspects; treatment; management of cerebral malaria; pathogenesis of cerebral malaria; prospective new therapies.
KW  - Anthelmintics
KW  - Antimalarials
KW  - Antiprotozoal agents
KW  - Developmental stages
KW  - drug therapy
KW  - helminths
KW  - Human diseases
KW  - Malaria
KW  - metacestodes
KW  - parasites
KW  - reviews
KW  - Apicomplexa
KW  - Cestoda
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Taenia solium
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Platyhelminthes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - chemotherapy
KW  - growth phase
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874472&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunity to protozoa.
AU  - Miller, L. H.
AU  - Scott, P.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1990///
VL  - 2
IS  - 3
SP  - 368
EP  - 374
SN  - 0952-7915
AD  - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879335.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Protozoology
N2  - Research on immunity to protozoa is reviewed under the headings of: malaria (pre-erythrocytic stage, asexual erythrocytic parasites, transmission-blocking immunity); Leishmania, Toxoplasma and Trypanosoma cruzi (T-cell subsets regulating protozoal immunity, role of cytokines in protozoal immunity, vaccine development).
KW  - Human diseases
KW  - immunity
KW  - parasites
KW  - reviews
KW  - Apicomplexa
KW  - Leishmania
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Sarcocystidae
KW  - Sarcomastigophora
KW  - Toxoplasma gondii
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Eucoccidiorida
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Trypanosoma
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879335&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunity to helminths.
AU  - Pearce, E. J.
AU  - Sher, A.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1990///
VL  - 2
IS  - 3
SP  - 375
EP  - 379
SN  - 0952-7915
AD  - Pearce, E. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19920879336.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Helminthology
N2  - As there have been dramatic advances in the understanding of the regulation of immune responses to helminths and in the development of effective, defined anti-helminth vaccines, this review concentrates on these 2 areas.
KW  - Helminths
KW  - Human diseases
KW  - immunity
KW  - immunization
KW  - parasites
KW  - reviews
KW  - Vaccines
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - immune sensitization
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879336&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Activity of ivermectin in human parasitic infections other than onchocerciasis.
AU  - Ottesen, E. A.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1990///
VL  - 3
IS  - 6
SP  - 834
EP  - 837
SN  - 0951-7375
AD  - Ottesen, E. A.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910874009.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Registry Number: 70288-86-7.  Subject Subsets: Helminthology
N2  - Clinical trials were carried out to determine the effectiveness of ivermectin against Wuchereria bancrofti, Brugia malayi, Loa loa, Mansonella perstans, Mansonella ozzardi, Ascaris lumbricoides, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, and hookworms. The findings from these trials are summarized in this review.
KW  - Anthelmintics
KW  - Developmental stages
KW  - drug therapy
KW  - filariids
KW  - helminths
KW  - Hookworms
KW  - Human diseases
KW  - ivermectin
KW  - parasites
KW  - reviews
KW  - Ascaris lumbricoides
KW  - Brugia malayi
KW  - Enoplida
KW  - Enterobius vermicularis
KW  - Loa loa
KW  - man
KW  - Mansonella ozzardi
KW  - Mansonella perstans
KW  - Nematoda
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Trichuris trichiura
KW  - Wuchereria bancrofti
KW  - Ascaris
KW  - Ascarididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Brugia
KW  - Onchocercidae
KW  - Enterobius
KW  - Oxyuridae
KW  - Loa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Mansonella
KW  - Strongyloides
KW  - Strongyloididae
KW  - Trichuris
KW  - Trichuridae
KW  - Trichinellida
KW  - Dorylaimia
KW  - Enoplea
KW  - Wuchereria
KW  - Enoplia
KW  - Adenophorea
KW  - African eyeworm
KW  - Ascaridida
KW  - chemotherapy
KW  - growth phase
KW  - nematodes
KW  - parasitic worms
KW  - pinworm
KW  - Secernentea
KW  - Spirurida
KW  - threadworm
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chinese food composition tables.
AU  - Ershow, A. G.
AU  - Wong-Chen, K.
JO  - Journal of Food Composition and Analysis
JF  - Journal of Food Composition and Analysis
Y1  - 1990///
VL  - 3
IS  - 3/4
SP  - 191
EP  - 434
SN  - 0889-1575
AD  - Ershow, A. G.: Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Diseases, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921442183.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition; Dairy Science
N2  - The Chinese Food Composition Tables, representing 4 decades of effort by the Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, are presented in annotated translation with extensive supplementary material. Nutrient data for more than 600 foods include edible portion; proximate composition; energy, major mineral, trace element, vitamin and cholesterol content; and amino acid and fatty acid profile. Categories of foods represented include cereals; legumes; roots, tubers and stems; cultivated and wild vegetables; melons, squashes and gourds; fungi and algae; fruits; nuts; meats, poultry and eggs; dairy foods; fishes; molluscs, crustaceans and other invertebrates; reptiles and amphibians; alcoholic and non-alcoholic beverages; condiments; confections; and infant foods. Foods are identified by English common name and Latin scientific name, and are further described by habitat (for water-dwelling creatures), cooking and preparation method, location of sample collection or analysis, and other characteristics. Original Chinese descriptions of foods are presented in Pinyin transliteration. Textual material and footnotes from the original Chinese document are translated in full. Linking codes are provided for readers having access to the original Chinese version. Detailed three-language index (English-Latin-Chinese) allow ready identification and location of food items throughout all tables. Analytical methods used to obtain the data are described. Information is provided on the retention of vitamins in cooked foods, Chinese market units of weight and measure, and cooking and preparation techniques. A concluding discussion addresses the applicability and limitations of the tables, indicates statistical approaches to the data, and places this document in perspective with other food composition tables.
KW  - Cows
KW  - Food composition
KW  - Foods
KW  - China
KW  - cattle
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - People's Republic of China
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Food Composition and Quality (QQ500) 
KW  - Milk and Dairy Produce (QQ010) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrition and cancer prevention activities in state health agencies.
AU  - Heimendinger, J.
AU  - Foerster, S.
AU  - Kaufman, M.
AU  - Light, L.
JO  - Health Education Research
JF  - Health Education Research
Y1  - 1990///
VL  - 5
IS  - 4
SP  - 545
EP  - 550
SN  - 0268-1153
AD  - Heimendinger, J.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921449218.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
N2  - Opinions from key personnel about nutrition and cancer prevention activities in the USA are reported. The majority of respondents felt that the science base linking diet and cancer was sufficient to warrant public health action, especially public education and interagency collaboration though fewer viewed environmental change, such as collaborative efforts with supermarkets or efforts to mobilize whole communities as priorities.
KW  - health services
KW  - Neoplasms
KW  - nutrition
KW  - prevention
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Education, Extension, Information and Training (General) (CC000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis.
AU  - Knowler, W. C.
AU  - Pettitt, D. J.
AU  - Saad, M. F.
AU  - Bennett, P. H.
JO  - Diabetes/Metabolism Reviews
JF  - Diabetes/Metabolism Reviews
Y1  - 1990///
VL  - 6
IS  - 1
SP  - 1
EP  - 27
SN  - 0742-4221
AD  - Knowler, W. C.: Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
N1  - Accession Number: 19921441489.  Publication Type: Journal Article.  Language: English.  Number of References: 149 ref. Subject Subsets: Human Nutrition
N2  - The Pima Indians of Arizona have the highest recorded prevalence and incidence of non-insulin-dependent diabetes of any geographically-defined population. In this review the prevalence, incidence, risk factors and pathogenesis of diabetes in the Pima Indians are discussed. The epidemiological evidence indicates that non-insulin-dependent diabetes results from interaction of genetic and environmental factors. The principal goal of epidemiological research in diabetes is prevention or postponement of the onset of the disease. Further expansion of the knowledge of genetics of the disease to allow identification of susceptible subjects has important implications for intervention strategies. These may be tested in populations known to be susceptible to the disease and therefore more likely to benefit. Based on the current knowledge of the epidemiology and risk factors for the disease, intervention approaches involving drugs, diet and exercise appear to have the potential to reduce the incidence of diabetes in subjects at high risk.
KW  - diabetes
KW  - Ethnic groups
KW  - reviews
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of nitrogen oxides as effector molecules of parasite killing.
AU  - James, S. L.
AU  - Hibbs, J. B., Jr.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1990///
VL  - 6
IS  - 9
SP  - 303
EP  - 305
AD  - James, S. L.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872936.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Protozoology; Helminthology
N2  - The novel mammalian biochemical pathways for the synthesis of inorganic nitrogen oxides that mediate antibody-independent killing of infectious agents (including extracellular helminths, extracellular fungi and intracellular protozoa) as well as of tumour cells are discussed.
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - nitrogen oxides
KW  - Parasites
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vector-spirochete relationships in louse-borne and tick-borne borrelioses with emphasis on Lyme disease.
AU  - Burgdorfer, W.
AU  - Hayes, S. F.
JO  - Advances in Disease Vector Research
JF  - Advances in Disease Vector Research
Y1  - 1990///
VL  - 6
SP  - 127
EP  - 150
CY  - New York; USA
PB  - Springer-Verlag
SN  - 0387970800\3540970800
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19910502000.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Salient findings on the development and transmission of Borrelia burgdorferi in and through its Ixodes vectors are compared and contrasted with these aspects of B. recurrentis, B. duttonii and B. theileri (among other borreliae) in their respective louse (Pediculus humanus) and tick (Ornithodoros moubata, Rhipicephalus spp., Boophilus spp.) vectors. After a brief historical introduction, a table summarizes the characteristics and geographical distribution of all arthropod-borne borreliae. Three sections then follow on the behaviour of louse-borne and tick-borne spirochaetes, of B. theileri, and of B. burgdorferi in their vectors, then a section on the relationship of B. burgdorferi to non-specific tick vectors (notably Dermacentor variabilis, Amblyomma americanum, and ticks of the jack rabbit Lepus californicus californicus) and other haematophagous arthropods (Chrysops callidus, Aedes spp.), and finally a section identified "B. burgdorferi: subject to a complex development cycle? ". In conclusion, the main points and areas for further research in this fast-moving subject are highlighted, including the apparent relative unimportance of transovarial transmission for B. burgdorferi, the likelihood that Haemaphysalis leporipalustris and I. dentatis play a role in maintaining B. burgdorferi in lagomorph populations, the possibility of mechanical transmission by Chrysops, Tabanus and mosquitoes, and certain complexities of spirochaete development in their arthropod and vertebrate hosts.
KW  - disease vectors
KW  - host parasite relationships
KW  - reviews
KW  - Tickborne diseases
KW  - vectors
KW  - Zoonoses
KW  - Acari
KW  - Anoplura
KW  - Arachnida
KW  - Argasidae
KW  - Borrelia
KW  - Borrelia burgdorferi
KW  - Borrelia duttonii
KW  - Borrelia recurrentis
KW  - Borrelia theileri
KW  - Culicidae
KW  - Diptera
KW  - Ixodes scapularis
KW  - Ixodidae
KW  - Lagomorpha
KW  - Leporidae
KW  - Mammals
KW  - Pediculus
KW  - Phthiraptera
KW  - Spirochaetaceae
KW  - Tabanidae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Phthiraptera
KW  - insects
KW  - Hexapoda
KW  - Metastigmata
KW  - Acari
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Borrelia
KW  - Diptera
KW  - Ixodes
KW  - Ixodidae
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Lagomorpha
KW  - Pediculidae
KW  - Anoplura
KW  - bacterium
KW  - Ixodes dammini
KW  - Louse-borne diseases
KW  - mosquitoes
KW  - parasite host relationships
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Aquatic Biology and Ecology (MM300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Strategies for cancer prevention through diet modification.
AU  - Greenwald, P.
AU  - Light, L.
AU  - McDonald, S. S.
AU  - Stern, H. R.
JO  - Medical Oncology and Tumor Pharmacotherapy
JF  - Medical Oncology and Tumor Pharmacotherapy
Y1  - 1990///
VL  - 7
IS  - 2/3
SP  - 199
EP  - 200
AD  - Greenwald, P.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Building 31, Room 10A52, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911431192.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 60 ref. Subject Subsets: Human Nutrition
N2  - Strategies for cancer prevention through diet modification are described, with emphasis on the translation of basic scientific knowledge into effective applications that can result in increased public health benefits. The discussion addresses diet and chemoprevention-related cancer prevention research at the National Cancer Institute; the formulation of interim dietary guidelines; channels for delivering dietary guidance to the public to promote consumer diet modification; and the potential influence of biotechnology and the changing food supply on lowering cancer incidence.
KW  - Carcinogenesis
KW  - diets
KW  - prevention
KW  - Sweden
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - Nutrition and cancer
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi.
AU  - Simpson, W. J.
AU  - Garon, C. F.
AU  - Schwan, T. G.
JO  - Microbial Pathogenesis
JF  - Microbial Pathogenesis
Y1  - 1990///
VL  - 8
IS  - 2
SP  - 109
EP  - 118
SN  - 0882-4010
AD  - Simpson, W. J.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950800299.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref.
KW  - human diseases
KW  - Lyme disease
KW  - plasmids
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800299&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Blood magnesium parameters do not differ with age.
AU  - Yang, X. Y.
AU  - Hosseini, J. M.
AU  - Ruddel, M. E.
AU  - Elin, R. J.
JO  - Journal of the American College of Nutrition
JF  - Journal of the American College of Nutrition
Y1  - 1990///
VL  - 9
IS  - 4
SP  - 308
EP  - 313
SN  - 0731-5724
AD  - Yang, X. Y.: Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911429727.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 7439-95-4.  Subject Subsets: Human Nutrition
N2  - For 104 normal male and female volunteers, aged 11-75 years, the magnesium concentration (mEq/litre) averaged 1.63±0.01 in blood plasma, 4.55±0.06 in erythrocytes and 19.6±0.03 in mononuclear blood cells; the amount in mononuclear blood cells was 72.8±1.0 fg per cell. There was no effect of age (P&lt;0.05) on these values.
KW  - age
KW  - blood
KW  - Magnesium
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429727&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy balance, body size, and cancer.
AU  - Albanes, D.
JO  - Critical Reviews in Oncology/Hematology
JF  - Critical Reviews in Oncology/Hematology
Y1  - 1990///
VL  - 10
IS  - 3
SP  - 283
EP  - 303
AD  - Albanes, D.: Cancer Prevention Studies Branch, EPN-211, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892-4200, USA.
N1  - Accession Number: 19931457237.  Publication Type: Journal Article.  Language: English.  Number of References: 245 ref. Subject Subsets: Human Nutrition
N2  - Research dealing with energy balance and body size as they relate to human neoplasms is reviewed. Increased energy intake and physical inactivity heighten the risk of breast, large bowel and other neoplasms. Large body size and fatness, as measured by adult stature, body weight and body mass indices, are positively related to a variety of neoplasms, including breast, colorectum, prostate, endometrium, kidney and ovary, as well as to total neoplasm incidence or mortality in many investigations, although conflicting reports exist. Adult weight gain has also been specifically implicated in a few aetiologic studies of breast and large bowel neoplasms. Furthermore, increased birth weight and child stature have been linked to increased risk of leukaemia, lymphoma, osteogenic sarcoma and central nervous system malignancies between infancy and young adulthood. Greater body weight also adversely affects breast neoplasm survival. These findings are complementary and support a role for positive energy balance in promoting human carcinogenesis. Potential mechanisms are discussed.
KW  - Body weight
KW  - Carcinogenesis
KW  - Energy balance
KW  - Reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hantavirus infection in the United States: epizootiology and epidemiology.
AU  - Yanagihara, R.
JO  - Reviews of Infectious Diseases
JF  - Reviews of Infectious Diseases
Y1  - 1990///
VL  - 12
IS  - 3
SP  - 449
EP  - 457
AD  - Yanagihara, R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5B-21, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930517820.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Subject Subsets: Public Health
N2  - Multiple species of murid and arvicolid (microtine) rodents serve as reservoir hosts of hantaviruses, the aetiologic agents of haemorrhagic fever with renal syndrome. Three antigenically distinct hantaviruses have been isolated from Rattus norvegicus, Mus musculus and Microtus pennsylvanicus captured in the USA, and serological evidence of a hantavirus enzootic has been found in several other indigenous rodent species. In residential districts of port cities such as Baltimore (Maryland), nearly 50% of R. norvegicus rats are infected with viruses that are serologically indistinguishable from disease-causing Hantavirus strains isolated from rats in the Far East. Despite the widespread distribution of Hantavirus-infected rodents, confirmed cases of haemorrhagic fever with renal syndrome have not been recognised in USA. Moreover, the overall risk of hantavirus infection in humans in USA is low, even among individuals who have frequent exposure to commensal and wild rodents. Studies are needed to define the clinical spectrum of hantavirus infection in humans in the USA.
KW  - Epidemiology
KW  - Haemorrhagic fever with renal syndrome
KW  - haemorrhagic fevers
KW  - Human diseases
KW  - infections
KW  - introduced species
KW  - Reviews
KW  - viral diseases
KW  - Zoonoses
KW  - USA
KW  - Hantavirus
KW  - Rats
KW  - Rattus norvegicus
KW  - Rodents
KW  - Bunyaviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Rattus
KW  - Murinae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - America (North)
KW  - brown rat
KW  - exotic organisms
KW  - exotic species
KW  - hemorrhagic fever with renal syndrome
KW  - hemorrhagic fevers
KW  - introduced organisms
KW  - naturalized species
KW  - non-indigenous organisms
KW  - non-indigenous species
KW  - non-native organisms
KW  - non-native species
KW  - nonindigenous organisms
KW  - nonindigenous species
KW  - Norway rat
KW  - United States of America
KW  - viral infections
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Experimental basis for use of fluconazole for preventive or early treatment of disseminated candidiasis in granulocytopenic hosts.
AU  - Walsh, T. J.
AU  - Lee, J.
AU  - Aoki, S.
AU  - Mechinaud, F.
AU  - Bacher, J.
AU  - Lecciones, J.
AU  - Thomas, V.
AU  - Rubin, M.
AU  - Pizzo, P. A.
JO  - Reviews of Infectious Diseases
JF  - Reviews of Infectious Diseases
Y1  - 1990///
VL  - 12
IS  - Suppl. 3
SP  - S307
EP  - S317
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901207008.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 27 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - To determine the potential for the use of fluconazole for prevention and treatment of disseminated Candida albicans infection in granulocytopenic patients, its activity and pharmacokinetics were investigated in models of acute, subacute and chronic forms of disseminated candidosis in persistently granulocytopenic rabbits. Fluconazole was administered for systemic prophylaxis, early treatment and delayed treatment. Single-dose and steady-state plasma pharmacokinetics, tissue penetration and dose-response studies of fluconazole were studied in subacutely infected granulocytopenic rabbits. Fluconazole was more effective when used for systemic prophylaxis or early treatment of disseminated candidosis than for delayed treatment. Fluconazole was as effective as amphotericin B plus flucytosine in preventive and early treatment of disseminated candidosis but was significantly less effective than amphotericin plus flucytosine in the treatment of chronic candidosis. Dose-response studies demonstrated that the antifungal effect of fluconazole was dose- and time-dependent. Studies of the pharmacokinetics of fluconazole in rabbits demonstrated a long half-life in plasma and a large volume of distribution, properties that correspond to the attainment of high levels of penetration into tissues at multiple organ sites. It is concluded that fluconazole is effective for prevention and early treatment of disseminated candidosis in persistently granulocytopenic rabbits and that the evaluation of its use in preventive or early treatment of disseminated candidosis in carefully designed clinical trials is warranted.
KW  - Antifungal agents
KW  - fluconazole
KW  - generalized infections
KW  - infections
KW  - pharmacokinetics
KW  - predisposition
KW  - prophylaxis
KW  - therapy
KW  - Candida albicans
KW  - mice
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Fluconazole -a novel advance in therapy for systemic fungal infections
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increasing usage of systemic antifungal agents.
AU  - Walsh, T. J.
AU  - Jarosinski, P. F.
AU  - Fromtling, R. A.
JO  - Diagnostic Microbiology and Infectious Disease
JF  - Diagnostic Microbiology and Infectious Disease
Y1  - 1990///
VL  - 13
IS  - 1
SP  - 37
EP  - 40
SN  - 0732-8893
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901205910.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 1397-89-3, 2022-85-7, 65277-42-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - Findings of the Committee on Antifungal Therapeutics of the Medical Mycology Society of the Americas which evaluated the chronological trends of worldwide antifungal usage since 1983 are summarized. During 1983-1987, worldwide sales of the 3 principal systemic antifungal compounds, ketoconazole, amphotericin B and flucytosine, increased substantially. Results of studies at a large medical referral centre indicated that this was due to a combination of increased usage and increased cost of the antifungals. The implications of these trends toward management of systemic mycoses are discussed.
KW  - Amphotericin B
KW  - Antifungal agents
KW  - Flucytosine
KW  - Ketoconazole
KW  - mycoses
KW  - therapy
KW  - 5-fluorocytosine
KW  - fungistats
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205910&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - International differences in body height and weight and their relationship to cancer incidence.
AU  - Albanes, D.
AU  - Taylor, P. R.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1990///
VL  - 14
IS  - 1
SP  - 69
EP  - 77
SN  - 0163-5581
AD  - Albanes, D.: EPN-211, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901452595.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Human Nutrition
N2  - The relation between body size (adult height and weight) and cancer incidence was investigated in an international ecological study of 24 populations. Site-specific and total cancer incidence rates (age-standardized) from 1973 to 1977 were correlated with body size data generally obtained between 1954 and 1974. All-sites cancer incidence was highly correlated with height among men and women. Among men, there were significant correlations between height and cancers of the central nervous system, prostate, bladder, pancreas, lung and colon. Significant correlations were observed for cancers of the rectum, pancreas, ovary, central nervous system, breast, uterine corpus and bladder in women. Adjustment for weight altered these correlations only minimally. Weight was significantly correlated with all-sites cancer only among women and site-specific correlations were significant for the same sites as for height, but the magnitude of the correlation coefficients was somewhat diminished. In addition, adjustment for height greatly reduced the correlations with weight. These findings support previously observed associations between height and specific cancers (e.g., breast and colon) and identify several additional cancer sites that may be similarly related.
KW  - body weight
KW  - Carcinogenesis
KW  - height
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Widespread visceral calcifications in disseminated Pneumocystis carinii infection: CT characteristics.
AU  - Feuerstein, I. M.
AU  - Francis, P.
AU  - Raffeld, M.
AU  - Pluda, J.
JO  - Journal of Computer Assisted Tomography
JF  - Journal of Computer Assisted Tomography
Y1  - 1990///
VL  - 14
IS  - 1
SP  - 149
EP  - 151
SN  - 0363-8715
AD  - Feuerstein, I. M.: Diagnostic Radiology Department, Bldg. 10, Rm. 1C660, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910870622.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Protozoology
N2  - The case of a 29-year-old man from the USA, with AIDS and disseminated P. carinii infection, is presented. Calcifications of similar character were found by CT in the lymph nodes, spleen, liver, and kidneys. Biopsy of a calcified axillary lymph node demonstrated necrotizing granulomatous lymphadenitis, with Pneumocystis organisms and dystrophic calcifications clustered centrally within the granulomas.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - case reports
KW  - computed tomography
KW  - diagnosis
KW  - disseminated infections
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910870622&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Atypical pathologic manifestations of Pneumocystis carinii pneumonia in the acquired immune deficiency syndrome. Review of 123 lung biopsies from 76 patients with emphasis on cysts, vascular invasion, vasculitis, and granulomas.
AU  - Travis, W. D.
AU  - Pittaluga, S.
AU  - Lipschik, G. Y.
AU  - Ognibene, F. P.
AU  - Suffredini, A. F.
AU  - Masur, H.
AU  - Feuerstein, I.
AU  - Kovacs, J.
AU  - Pass, H. I.
AU  - Condron, K. S.
AU  - Shelhamer, J. H.
JO  - American Journal of Surgical Pathology
JF  - American Journal of Surgical Pathology
Y1  - 1990///
VL  - 14
IS  - 7
SP  - 615
EP  - 625
SN  - 0147-5185
AD  - Travis, W. D.: Laboratory of Pathology, Building 10, Room 2N212, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910870659.  Publication Type: Journal Article.  Language: English.  Number of References: 80 ref. Subject Subsets: Protozoology
N2  - The frequency of atypical pathological manifestations of P. carinii pneumonia (PCP) were studied in 123 lung biopsy specimens from 76 National Institutes of Health patients from Maryland, USA, with the acquired immune deficiency syndrome. The following atypical features were observed: interstitial (63%) and intraluminal (36%) fibrosis, absence of alveolar exudate (19%), numerous alveolar macrophages (9%), granulomatous inflammation (5), hyaline membranes (4%), marked interstitial pneumonitis (3%), parenchymal cavities (2%), interstitial microcalcification (2%), minimal histological reaction (2%), and vascular invasion with vasculitis (1%). These atypical features are discussed with emphasis on the significance of cavities, vascular invasion, vasculitis, and granulomas. Immunohistochemical staining with MAbs to the 2G2 and 6B8 antigens of P. carinii in paraffin-embedded lung biopsy specimens, did not indicate any diagnostic advantage over routine methenamine silver stains.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - lungs
KW  - Opportunistic infections
KW  - parasites
KW  - pathology
KW  - Maryland
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - prevalence
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910870659&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diet and oral and pharyngeal cancer among Blacks.
AU  - Gridley, G.
AU  - McLaughlin, J. K.
AU  - Block, G.
AU  - Blot, W. J.
AU  - Winn, D. M.
AU  - Greenberg, R. S.
AU  - Schoenberg, J. B.
AU  - Preston-Martin, S.
AU  - Austin, D. F.
AU  - Fraumeni, J. F., Jr.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1990///
VL  - 14
IS  - 3&4
SP  - 219
EP  - 225
SN  - 0163-5581
AD  - Gridley, G.: National Cancer Institute, Division of Cancer Etiology, Epidemiology and Biostatistics Program, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911432062.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Human Nutrition
N2  - Data from a population-based multicentre case-control study were examined to assess the relationship between diet and oral and pharyngeal cancer among blacks. An increased intake of fruits and vegetables was associated with a decreased risk for oral cancer among men and women, although the protective effect was stronger among men. Risk also declined in both sexes with an increase in the consumption of vitamin C and fibre and in men only for carotene and vitamin E. No associations were found with an intake of smoked, pickled, or charcoal-grilled meats or of hot beverages. However, the consumption of nitrite-containing meats was linked to increased risk among men. The dietary patterns of risk for blacks were generally similar to those previously reported for whites; however, a lower consumption of fruits and vegetables among blacks may contribute to their higher rates of oral and pharyngeal cancer.
KW  - carcinogenesis
KW  - diets
KW  - Ethnic groups
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy expenditure in the obese: is there a thrifty gene?
AU  - Ravussin, E.
AU  - Bogardus, C.
JO  - Infusionstherapie, Internationale Zeitschrift für Infusionstherapie, Klinische Ernährung und Transfusionsmedizin
JF  - Infusionstherapie, Internationale Zeitschrift für Infusionstherapie, Klinische Ernährung und Transfusionsmedizin
Y1  - 1990///
VL  - 17
IS  - 2
SP  - 108
EP  - 112
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19911431625.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - At present 7000 to 8000 Pima Indians live in the southwestern desert of Arizona, USA. The prevalence of type II diabetes in this population exceeds 45% and more than 75% of the Pimas are obese. In 1962, Neel [American Journal of Human Genetics (1962) 14, 353] proposed that obesity in populations like the Pima Indians might be the expression of a "thrifty gene" which becomes detrimental with progress. Since 1982, longitudinal studies have been made including estimations of metabolic rate in 200 non-diabetic Pima Indians and have shown that at any given body weight and body composition, there is quite a large variability in the resting metabolic rate which is not accounted for by intra-individual variability or errors of the methods. Metabolic rate after adjustment for body composition and body weight is a familial trait. A low metabolic rate is a risk factor for body weight gain. In response to body weight gain, there is a 'normalization' of the resting metabolic rate.
KW  - Ethnic groups
KW  - metabolism
KW  - obesity
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fungal infections in the pediatric cancer patient.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Seminars in Oncology
JF  - Seminars in Oncology
Y1  - 1990///
VL  - 17
IS  - 3, Suppl. 6
SP  - 6
EP  - 9
AD  - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911210389.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Factors such as neutropenia which predispose paediatric cancer patients to fungal infections, common sites of infection, the emerging problem of hepatic Candida infections and antifungal therapy, both experimental efficacy studies and empirical use in high-risk patients, are discussed.
KW  - children
KW  - infections
KW  - liver
KW  - Mycoses
KW  - neoplasms
KW  - neutropenia
KW  - predisposition
KW  - Candida
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - cancers
KW  - Fungal infections in the cancer patient - clinical experience with fluconazole
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recominant baculovirus-infected insect cells.
AU  - Marcy, A. I.
AU  - Olivo, P. D.
AU  - Challberg, M. D.
AU  - Coen, D. M.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1990///
VL  - 18
IS  - 5
SP  - 1207
EP  - 1215
SN  - 0305-1048
AD  - Marcy, A. I.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900598554.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Biochemical characterization of the herpes simplex virus (HSV) DNA polymerase, a model DNA polymerase and an important target for antiviral drugs, has been limited by a lack of pure enzyme in sufficient quantity. To overcome this limitation, the HSV DNA polymerase gene was introduced into the baculovirus, Autographa californica nuclear polyhedrosis virus, under the control of the polyhedrin promotor to give rise to a recombinant baculovirus, BP58. BP58-infected Spodoptera frugiperda insect cells expressed a polypeptide that was indistinguishable from authentic polymerase by several immunological and biochemical properties, at levels approximately 10-fold higher per infected cell than found in HSV-infected Vero cells. The DNA polymerase was purified to apparent homogeneity from BP58-infected insect cells. Using activated DNA as primer-template, the purified enzyme exhibited specific activity similar to that of enzyme isolated from HSV-infected Vero cells, indicating that additional polymerase-associated proteins from HSV-infected cells are not critical for activity with this primer-template. 3′-5′ exonuclease activity co-purified with the BP58-expressed HSV DNA polymerase, demonstrating that this activity is intrinsic to the polymerase polypeptide. The purified enzyme also exhibited RNAse H activity. The recombinant baculovirus should permit detailed biochemical and biophysical studies of this enzyme.
KW  - biotechnology
KW  - Cell lines
KW  - DNA
KW  - Enzymes
KW  - Gene expression
KW  - herpes simplex viruses
KW  - human herpesviruses
KW  - Baculovirus
KW  - Herpesviridae
KW  - Spodoptera frugiperda
KW  - Baculoviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Spodoptera
KW  - Noctuidae
KW  - Lepidoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Herpesviridae
KW  - Cloning
KW  - deoxyribonucleic acid
KW  - herpes simplex virus
KW  - Human herpesvirus
KW  - Vertebrate viruses
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biological Control (HH100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A heat shock protein gene in Giardia lamblia unrelated to HSP70.
AU  - Aggarwal, A.
AU  - Cruz, V. F. de la
AU  - Nash, T. E.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1990///
VL  - 18
IS  - 11
SP  - 3409
EP  - 3409
SN  - 0305-1048
AD  - Aggarwal, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872903.  Publication Type: Journal Article.  Language: English.  Number of References: 2 ref. Subject Subsets: Protozoology; Agricultural Biotechnology
N2  - A 4.2 kb HindIII gene fragment from G. lamblia trophozoites strain WB, selected by 32P labelled HSP70 clone pPW229 of Drosophila was cloned into pUC19 (pUCG2c). The sequence was determined by sequencing both strands of overlapping restriction fragments. The sequence contained a 5′ non-coding region of 141 bases followed by 1593 nucleotides showing a single continuous open reading frame starting with a putative initiator at position 142. No homology in the coding sequence was identified with D. melanogaster HSP70 or any other HSPs reported in literature. However, an HSP like motif at position 73-86 and a TATAA box at position 109-113 were identified which suggests that functional controlling elements are present in this gene.
KW  - Biotechnology
KW  - heat shock proteins
KW  - Molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - GIARDIA DUODENALIS
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872903&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary protein and blood pressure in monozygotic twins.
AU  - Havlik, R. J.
AU  - Fabsitz, R. R.
AU  - Kalousdian, S.
AU  - Borhani, N. O.
AU  - Christian, J. C.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1990///
VL  - 19
IS  - 1
SP  - 31
EP  - 39
SN  - 0091-7435
AD  - Havlik, R. J.: R. R. Fabsitz, National Heart, Lung, and Blood Institute, Federal Building, Room 300, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911429742.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - Cross-sectional studies relating blood pressure to dietary intake have been confounded due to the high genetic component of blood pressure. Intervention studies, using the same subject as his own control, often encounter additional problems when subjects are asked to adhere to an alternate diet. The National Heart, Lung, and Blood Institute Twin Study of middle-aged men provided information concerning the possible relation of food-frequency-estimated nutrient intake to blood pressure while controlling for genetic effects in a free-living group of subjects. Using differences in monozygotic twins, a direct association of dietary protein intake and diastolic blood pressure was identified and persisted after adjustment for known covariates of blood pressure. Adjusting for known covariates and holding total calories constant, a 9-g difference in daily protein intake was directly associated with a 1 mm Hg difference in diastolic blood pressure. For protein intake as a percentage of total calories, a 2.18% difference was directly associated with a 1 mm Hg difference in diastolic blood pressure. The co-twin-control method provides a powerful design to investigate the interrelation between nutrients and blood pressure in an observational as well as an experimental situation.
KW  - Blood pressure
KW  - protein intake
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429742&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - N-acetyltransferase activity in bilharzial infested mice.
AU  - Zakhary, N. I.
AU  - Dahawy, H. S.
AU  - El-Asser, A. B.
JO  - Pakistan Journal of Biochemistry
JF  - Pakistan Journal of Biochemistry
Y1  - 1990///
VL  - 23
IS  - 2
SP  - 63
EP  - 68
SN  - 0300-8185
AD  - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo, Egypt.
N1  - Accession Number: 19930808441.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Helminthology
KW  - duodenum
KW  - enzyme activity
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - laboratory animals
KW  - liver
KW  - parasites
KW  - pathology
KW  - transferases
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy metabolism and obesity. / Métabolisme énergétique et obésité.
AU  - Ravussin, E.
AU  - Zurlo, F.
JO  - Cahiers de Nutrition et de Diététique
JF  - Cahiers de Nutrition et de Diététique
Y1  - 1990///
VL  - 25
IS  - 3
SP  - 171
EP  - 175
SN  - 0007-9960
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19911437088.  Publication Type: Journal Article.  Language: French.  Language of Summary: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Relations between energy metabolism and obesity are reviewed. The author's own research on energy expenditure and its components (resting metabolic rate (RMR), heat effect of food and energy cost of physical activity) in more than 400 persons showed the potential role of energy expenditure in the development of obesity. From a methodological viewpoint, it is insufficient to express RMR in relation to fat-free mass, although it explains 82% of the variance of RMR. A multiple regression line taking into account fat-free mass, body fat, age and sex was used to obtain a predicted value and to analyse the measured values with regard to the predicted value. It seemed that experimental values could vary around the predicted value by some 300 kcal which underlines the heterogeneity of individuals beyond their difference in body composition. This variability of energy metabolism is in a large part determined genetically. Variations in energy expenditure above or below the predicted value are indicators of the ability of persons to gain weight with time and represent a predictive factor of obesity. A reduction in the capacity to oxidize fats is also linked to an increased risk to gain weight.
KW  - energy metabolism
KW  - Obesity
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutations with multiple independent origins in surface antigens mark the targets of biological selective pressure.
AU  - McCutchan, T. F.
AU  - Waters, A. P.
JO  - Immunology Letters
JF  - Immunology Letters
Y1  - 1990///
VL  - 25
IS  - 1-3
SP  - 23
EP  - 26
SN  - 0165-2478
AD  - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869109.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 10 ref. Subject Subsets: Protozoology
N2  - The existence and importance of a small subset of mutations in Plasmodium falciparum genes that continually reoccur in separated populations is documented. A description of how to identify recurrent mutations using a novel application of pre-existing computer programs designed to trace genealogy is given. The most striking example of this phenomenon occurred in the cytotoxic T-cell epitope of the circumsporozoite (CS) protein of P. falciparum, where identical sequence types clearly have multiple independent origins. The importance of this observation is that it conclusively demonstrates selective pressure on these sequences and indicates that there is a significant natural mechanism relating to the CS protein that affects the success of malaria sporozoites.
KW  - circumsporozoite protein
KW  - Evolution
KW  - genetics
KW  - Human diseases
KW  - mutations
KW  - natural selection
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunogenicity of Plasmodium falciparum sexual stage antigens: implications for the design of a transmission blocking vaccine.
AU  - Kaslow, D. C.
JO  - Immunology Letters
JF  - Immunology Letters
Y1  - 1990///
VL  - 25
IS  - 1-3
SP  - 83
EP  - 86
SN  - 0165-2478
AD  - Kaslow, D. C.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room B1-37, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869120.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 11 ref. Subject Subsets: Protozoology
N2  - A discussion of the implications for the design of a transmission blocking vaccine for P. falciparum is presented. Immunogenicity of sexual stage antigens and boosting of transmission blocking antibodies following a natural infection, are 2 critical factors in the design of an effective, subunit vaccine to block the transmission of malaria from man to mosquito. Immunogenicity and boosting are both T cell-dependent. Antigens, such as the 230 000 MW, the 48/45 000 MW, and the 40/10 000 MW, expressed early in the extracellular forms of the sexual stage of P. falciparum, have limited immunogenicity in humans and in mice. In contrast, Pfs25, expressed predominantly in zygotes and ookinetes, has widespread immunogenicity in mice. Pfs25, expressed by a recombinant vaccinia virus (vSIDK), is also widely immunogenic in mice, and induces transmission blocking antibodies following multiple inoculations with vSIDK. The implications of these immunogenicity data are discussed relative to the design of an effective transmission blocking vaccine.
KW  - antigens
KW  - Experimental infection
KW  - genetic regulation
KW  - Human diseases
KW  - immune response
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - antigenicity
KW  - experimental transmission
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - sexual stages
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cellular mechanisms in immunity to blood stage infection.
AU  - Kumar, S.
AU  - Miller, L. H.
JO  - Immunology Letters
JF  - Immunology Letters
Y1  - 1990///
VL  - 25
IS  - 1-3
SP  - 109
EP  - 114
SN  - 0165-2478
AD  - Kumar, S.: L.H. Miller, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869125.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 19 ref. Subject Subsets: Protozoology
N2  - Mechanisms of immunity to blood stage infection in the mouse malarias Plasmodium vinckei and P. yoelii 17X were investigated. Infection with P. vinckei was uniformly lethal, whereas P. yoelii 17X caused a self-limited, nonlethal infection. Transfer of immune CD4+ T cells conferred protection against P. yoelii in nude mice. Previous studies by others had suggested that immunity to P. yoelii may be related to MHC class I expression on reticulocytes, and found that CD8+ T cells alone transferred protection in immunodeficient mice. However, in these experiments, immune CD8+ T cells failed to transfer protection. In the P. vinckei system, both B cell-deficient and immunologically intact mice developed immunity to P. vinckei after parasite infection and drug cure. In vivo depletion of CD4+ T cells abrogated immunity in these immune mice. Adoptive transfer of CD4+ T cells failed to protect nude or normal mice from P. vinckei infection, but the transfer of immune CD4+ T cells reconstituted immunity in CD4-depleted immune mice. Splenectomy of immune mice resulted in the complete loss of immunity. Despite the fact that immunity to P. vinckei could be achieved with live parasite infection and drug cure, immunization of mice with killed P. vinckei with various adjuvants failed to protect mice from live challenge. In contrast, immunization with killed P. vinckei antigens in combination with attenuated Salmonella typhimurium SL3235 induced a high degree of protective immunity. These results suggest that induction of immunity against virulent malarias requires both induction of CD4+ T cells and certain splenic alterations caused by parasite infection or S. typhimurium. Successful vaccination against blood stage infection may require a combination of malarial antigen(s) to induce protective T cells and an agent which could create a malarial-type spleen. A vaccine comprising an attenuated strain of Salmonella expressing malarial genes might induce the cellular immunity and splenic changes required and, thereby, protect against human malarias.
KW  - Disease models
KW  - Human diseases
KW  - immunity
KW  - Laboratory animals
KW  - parasites
KW  - T lymphocytes
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium
KW  - Plasmodium vinckei
KW  - Plasmodium yoelii
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Method for in situ hybridization to polytene chromosomes from ovarian nurse cells of Anopheles gambiae (Diptera: Culicidae).
AU  - Graziosi, C.
AU  - Sakai, R. K.
AU  - Romans, P.
AU  - Miller, L. H.
AU  - Wellems, T. E.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1990///
VL  - 27
IS  - 5
SP  - 905
EP  - 912
SN  - 0022-2585
AD  - Graziosi, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900502326.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - A procedure for in situ hybridization to polytene chromosomes from the ovarian nurse cells of A. gambiae was developed. This procedure involves a modification of established methods for Drosophila larval salivary gland polytene chromosomes. Treatment of chromosome squashes with xylene followed by slow rehydration provides required resolution of chromosome banding patterns, possibly because fatty contaminants are removed from ovarian nurse cell preparations. Using this procedure, unique DNA sequences from a genomic library of A. gambiae were mapped on adult mosquito polytene chromosomes. The ability to locate genetic markers on chromosomes will allow correlation of physical and genetic maps. Such maps will facilitate identification of genetic loci and expand the knowledge of the genomic organization of A. gambiae.
KW  - Biotechnology
KW  - DNA
KW  - DNA hybridization
KW  - Gene mapping
KW  - genetics
KW  - in situ hybridization
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - polytene chromosomes
KW  - Techniques
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - Chromosome mapping
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - mosquitoes
KW  - Techniques and Methodology (ZZ900) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Administration of potassium iodide to normal volunteers does not increase killing of Sporothrix schenckii by their neutrophils or monocytes.
AU  - Rex, J. H.
AU  - Bennett, J. E.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1990///
VL  - 28
IS  - 3
SP  - 185
EP  - 189
SN  - 0268-1218
AD  - Rex, J. H.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901206974.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 7681-11-0.  Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - The mechanism by which iodide cures sporotrichosis was postulated to be an improvement in phagocyte-mediated killing of the causal fungus, S. schenckii. It was found that both neutrophils and monocytes could readily kill the fungus and that killing could be blocked by adding inhibitors of oxidative metabolism. Iodide, administered to 4 volunteers for 1 wk, raised their serum iodide level 213-fold but failed to improve killing of S. schenckii by their neutrophils or monocytes in a killing assay in vitro. Furthermore, addition of iodide directly to neutrophils at concn as high as 100µM did not augment killing.
KW  - Antifungal agents
KW  - immunology
KW  - monocytes
KW  - neutrophils
KW  - phagocytosis
KW  - pharmacodynamics
KW  - potassium iodide
KW  - therapy
KW  - Sporothrix schenckii
KW  - Sporothrix
KW  - Ophiostomataceae
KW  - Ophiostomatales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - drug action
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - killing
KW  - mechanism of drug action
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasive fusariosis associated with an injury by a stingray barb.
AU  - Hiemenz, J. W.
AU  - Kennedy, B.
AU  - Kwon-Chung, K. J.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1990///
VL  - 28
IS  - 3
SP  - 209
EP  - 213
SN  - 0268-1218
AD  - Hiemenz, J. W.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901206977.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - A case is reported in a previously healthy 34-yr-old man who suffered a wound to the dorsal ulnar aspect of his right hand by a stingray barb while fishing off the east coast of Florida. Two weeks after the imbedded barb had been surgically removed, an erythematous lesion developed around the wound. Histopathological and microbiological studies revealed infection caused by Fusarium solani. The patient was successfully treated with debridement and skin grafting in conjunction with ketoconazole therapy.
KW  - hosts
KW  - infections
KW  - invasion
KW  - Marine animals
KW  - mycoses
KW  - stings
KW  - transmission
KW  - wounds
KW  - USA
KW  - Dasyatidae
KW  - fishes
KW  - Fusarium
KW  - Haematonectria haematococca
KW  - man
KW  - Rajiformes
KW  - Chondrichthyes
KW  - fishes
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - aquatic organisms
KW  - aquatic animals
KW  - eukaryotes
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - Fusarium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Haematonectria
KW  - America (North)
KW  - fungus
KW  - Fusarium solani
KW  - Hyphomycetes
KW  - marine species
KW  - sting-ray injury
KW  - United States of America
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Is Candida stellatoidea disappearing from the vaginal mucosa ?
AU  - Kwon-Chung, K. J.
AU  - Wickes, B. L.
AU  - Salkin, I. R.
AU  - Kotz, H. L.
AU  - Sobel, J. D.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1990///
VL  - 28
IS  - 3
SP  - 600
EP  - 601
SN  - 0095-1137
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901205849.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A total of 681 vaginal isolates of germ tube-positive or germ tube-untested white, yeastlike fungi obtained from patients in various cities of the USA were tested for the presence of C. stellatoidea (type I). Only 1 of the 681 isolates was identified as C. stellatoidea.
KW  - hosts
KW  - infections
KW  - vagina
KW  - USA
KW  - Candida albicans
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Candida stellatoidea
KW  - fungus
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trichosporon beigelii, an emerging pathogen resistant to amphotericin B.
AU  - Walsh, T. J.
AU  - Melcher, G. P.
AU  - Rinaldi, M. G.
AU  - Lecciones, J.
AU  - McGough, D. A.
AU  - Kelly, P.
AU  - Lee, J.
AU  - Callender, D.
AU  - Rubin, M.
AU  - Pizzo, P. A.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1990///
VL  - 28
IS  - 7
SP  - 1616
EP  - 1622
SN  - 0095-1137
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901206583.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - T. beigelii caused fatal disseminated infections that were resistant to amphotericin B in 2 granulocytopenic patients (18- and 65-yr-old men). In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concn in serum. The min. lethal concn for both isolates was ≥18 µg/ml. Five of 7 other isolates were found to have a similar pattern of amphotericin B resistance. That the min. lethal concn of T. beigelii was many times greater than its MIC was consistent with a resistance pattern of tolerance. It is concluded that T. beigelii may be resistant in vitro to amphotericin B and that this in vitro resistance is correlated with refractory, disseminated trichosporonosis in granulocytopenic patients.
KW  - amphotericin B
KW  - Antifungal agents
KW  - death
KW  - disseminated infections
KW  - generalized infections
KW  - hosts
KW  - immunocompromised hosts
KW  - infections
KW  - patients
KW  - Piedra
KW  - predisposition
KW  - resistance
KW  - USA
KW  - man
KW  - Trichosporon beigelii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - amphotericin B resistance
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - United States of America
KW  - white
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Patterns of morphologic variation among isolates of Trichosporon beigelii.
AU  - Lee, J. W.
AU  - Melcher, G. A.
AU  - Rinaldi, M. G.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1990///
VL  - 28
IS  - 12
SP  - 2823
EP  - 2827
SN  - 0095-1137
AD  - Lee, J. W.: T. J. Walsh, Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901207824.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Considerable variability in colony and microscopic morphology among isolates of T. beigelii was observed. Deeply invasive clinical isolates showed 4 distinct morphotypes and spontaneous conversions among certain morphotypes and grew well at 37°C. In contrast, superficial clinical and environmental isolates did not demonstrate such morphotypes or conversions and most grew poorly at 37°C. It is concluded that the morphological and physiological features of invasive clinical isolates of T. beigelii follow certain patterns distinct from those of superficial clinical and environmental isolates.
KW  - morphology
KW  - Trichosporon beigelii
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207824&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequential resonance assignment and secondary structure determination of the Ascaris trypsin inhibitor, a member of a novel class of proteinase inhibitors.
AU  - Gronenborn, A. M.
AU  - Nilges, M.
AU  - Peanasky, R. J.
AU  - Clore, G. M.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1990///
VL  - 29
IS  - 1
SP  - 183
EP  - 189
SN  - 0006-2960
AD  - Gronenborn, A. M.: Laboratory of Chemical Physics, Building 2, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900868011.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 9002-07-7.  Subject Subsets: Helminthology
N2  - The solution conformation of the Ascaris suum trypsin inhibitor, a member of a novel class of proteinase inhibitors, was investigated by nuclear magnetic resonance spectroscopy. Complete sequence-specific assignments of the 1H NMR spectrum were obtained by using a number of 2-dimensional techniques for identifying through-bond and through-space (&lt;5-Å) connectivities. Elements of regular secondary structure were identified on the basis of a qualitative interpretation of the nuclear Overhauser enhancement, coupling constant, and amide exchange data. These are 2 β-sheet regions. One double-stranded antiparallel β-sheet comprises residues 11-14 (strand 1) and 37-39 (strand 2). The other triple-stranded sheet is formed by 2 antiparallel strands comprising residues 45-49 (strand 4) and 53-57 (strand 5) connected by a turn (residues 50-52), and a small strand consisting of residues 20-22 (strand 3) that is parallel to strand 4.
KW  - Biochemistry
KW  - Enzyme inhibitors
KW  - enzymes
KW  - helminths
KW  - Human diseases
KW  - Nuclear magnetic resonance
KW  - parasites
KW  - proteinase inhibitors
KW  - Trypsin
KW  - Ascaris suum
KW  - Nematoda
KW  - Ascaris
KW  - Ascarididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ascaridida
KW  - nematodes
KW  - parasitic worms
KW  - protease inhibitors
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Functional consequences of the proteolytic removal of regulatory serines from the nonhelical tailpiece of Acanthamoeba myosin II.
AU  - Sathyamoorthy, V.
AU  - Atkinson, M. A. L.
AU  - Bowers, B.
AU  - Korn, E. D.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1990///
VL  - 29
IS  - 15
SP  - 3793
EP  - 3797
SN  - 0006-2960
AD  - Sathyamoorthy, V.: E.D. Korn, Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869858.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 56-45-1.  Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activity of myosin II from A. castellanii is regulated by phosphorylation of 3 serines in its 29-residue, nonhelical, COOH-terminal tailpiece, i.e., serines-1489, -1494, and -1499 or, in reverse order, residues 11, 16, and 21 from the COOH terminus. To investigate the essential requirements for regulation, myosin II filaments in the presence of F-actin were digested by arginine-specific submaxillary gland protease. Two-dimensional peptide mapping of purified, cleaved myosin II showed that the 2 most terminal phosphorylation sites, serines-1494 and -1499, had been removed. Cleaved dephosphorylated myosin II retained full actin-activated Mg2+-ATPase activity (with no change in Vmax or Kapp) and the ability to form filaments similar to those of the native enzyme. However, higher Mg2+ concentrations were required for both filament formation and maximal ATPase activity. The one remaining regulatory serine in the cleaved myosin II was phosphorylatable by myosin II heavy-chain kinase, and phosphorylation inactivated the actin-activated Mg2+-ATPase activity, as in the case of the native myosin II. Also as in the native myosin II, phosphorylated cleaved myosin II inhibited the actin-activated Mg2+-ATPase activity of dephosphorylated cleaved myosin II when the 2 were copolymerized. These results suggest that at least 18 of the 29 residues in the nonhelical tailpiece of the heavy chain are not required for either actin-activated Mg2+-ATPase activity or filament formation and that phosphorylation of Ser-1489 is sufficient to regulate the actin-activated Mg2+-ATPase activity of myosin II.
KW  - Biochemistry
KW  - Enzymes
KW  - Human diseases
KW  - parasites
KW  - proteins
KW  - regulation
KW  - serine
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muscle filaments
KW  - myosin II
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinol metabolism in rats with low vitamin A status: a compartmental model.
AU  - Lewis, K. C.
AU  - Green, M. H.
AU  - Green, J. B.
AU  - Zech, L. A.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1990///
VL  - 31
IS  - 9
SP  - 1535
EP  - 1548
SN  - 0022-2275
AD  - Lewis, K. C.: Laboratory of Mathematical Biology, Room 4B-56, Building 10, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911433601.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - A compartmental model was developed to describe the metabolism of vitamin A in weaning male Sprague-Dawley rats with low vitamin A status maintained by a low dietary intake of vitamin A (about 2 µg retinol equivalent daily). The model predicted a vitamin A utilization rate of 1.65 µg retinol equivalents daily with urine and faeces accounting for most of the output. The plasma retinol turnover rate was about 20 µg retinol equivalents daily; this was 12 times the utilization rate, which suggested that, of the large amount of retinol moving through the plasma each day, less than 10% was being utilized. Similarly, as compared to the whole body utilization rate, there was a relatively higher turnover rate of retinol in the kidneys, carcass and liver, coupled with a high degree of recycling of vitamin A through these tissues. Of the total vitamin A that entered the liver from all sources including the diet, about 86% was mobilized into the plasma. Similarly, of the vitamin A that entered the carcass, about 76% was returned to the plasma. All of the retinol that entered the kidneys was modelled as recycling to the plasma.
KW  - metabolism
KW  - Retinol
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Both apolipoproteins B-48 and B-100 are synthesized and secreted by the human intestine.
AU  - Hoeg, J. M.
AU  - Sviridov, D. D.
AU  - Tennyson, G. E.
AU  - Demosky, S. J., Jr.
AU  - Meng, M. S.
AU  - Bojanovski, D.
AU  - Safonova, I. G.
AU  - Repin, V. S.
AU  - Kuberger, M. B.
AU  - Smirnov, V. N.
AU  - Higuchi, K.
AU  - Gregg, R. E.
AU  - Brewer, H. B., Jr.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1990///
VL  - 31
IS  - 10
SP  - 1761
EP  - 1769
SN  - 0022-2275
AD  - Hoeg, J. M.: Building 10, Room 7N117, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921440108.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Human Nutrition
N2  - Intestinal organ cultures from 6 normal adults were incubated in the presence of protease inhibitors in media supplemented with [35S]methionine. Media from these cultures were evaluated by sequential NaDodSO4 polyacrylamide gel electrophoresis, radioautography and Western blot analyses, and intestinal biopsies were studied using immunohistochemistry. The relative abundance of apolipoprotein (apo) B-100 and apoB-48 mRNA was assessed using reverse transcriptase-polymerase chain reaction followed by primer extension. Although apoB-48 was the principal isoprotein that was newly synthesized by intestinal organ cultures, apoB-100 was also synthesized and secreted by human intestinal organ cultures with 16±3% of the intestinal apoB mRNA coding for apoB-100. The results establish that apoB-100 is produced by the human intestine. The synthesis of the atherogenic apoB-100 by the intestine has pathophysiologic implications for the development of diet-induced atherosclerosis.
KW  - Apolipoproteins
KW  - intestines
KW  - secretion
KW  - synthesis
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A short tetraponerine synthesis.
AU  - Jones, T. H.
JO  - Tetrahedron Letters
JF  - Tetrahedron Letters
Y1  - 1990///
VL  - 31
IS  - 11
SP  - 1535
EP  - 1538
SN  - 0040-4039
AD  - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910502839.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A short synthesis of (±)-tetraponerine (a tricyclic alkaloid which is a toxic component of the venom of Tetraponera ants) stereoisomer T-4 and its "unnatural" isomer from the appropriate pyridyl ketone is described. This study included an investigation of the stereoselectivity of pyridine reduction in the conversion of an amine to the unnatural isomer and T-4.
KW  - Alkaloids
KW  - chemistry
KW  - synthesis
KW  - toxins
KW  - Venoms
KW  - Formicidae
KW  - Hymenoptera
KW  - Tetraponera
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Formicidae
KW  - Tetraponerine
KW  - venom
KW  - Plant Composition (FF040) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Chemistry (ZZ600) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Localization of nucleotide sequences on ovarian polytene chromosomes of the malaria vector Anopheles gambiae using in vitro hybridization. / Localizzazione di sequenze nucleotidiche sui cromosomi politenici ovarici del vettore di malaria Anopheles gambiae mediante ibridazione in situ..
AU  - Graziosi, C.
AU  - Sakai, R. K.
AU  - Romans, P.
AU  - Miller, L. H.
AU  - Wellems, T. E.
JO  - Parassitologia
JF  - Parassitologia
Y1  - 1990///
VL  - 32
SP  - 143
EP  - 144
AD  - Graziosi, C.: Malaria Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940502954.  Publication Type: Journal Article.  Language: Italian.  Language of Summary: English.  Number of References: 5 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - A procedure for in situ hybridization to ovarian polytene chromosomes of Anopheles gambiae was developed. Treatment of chromosome squashes with xylene provided required resolution of chromosome banding patterns. Using this procedure, 2 unique DNA sequences were mapped on adult mosquito polytene chromosomes.
KW  - DNA
KW  - DNA hybridization
KW  - molecular genetics
KW  - nucleotide sequences
KW  - Polytene chromosomes
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan.
AU  - Shulman, L. E.
JO  - Arthritis and Rheumatism
JF  - Arthritis and Rheumatism
Y1  - 1990///
VL  - 33
IS  - 7
SP  - 913
EP  - 917
SN  - 0004-3591
AD  - Shulman, L. E.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Room 4C-32, Building 31, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446001.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 73-22-3.  Subject Subsets: Human Nutrition
N2  - This editorial describes the history of the eosinophilia-myalgia syndrome (EMS), and reviews its clinical and pathological functions. The first notified cases occurred in the USA, and were drawn to the attention of the New Mexico Department of Health and Environment in October 1989. Subsequent reviews of eosinophil counts in laboratory records identified additional cases. Subjects suffering from EMS had been taking L-tryptophan products, and the US Food and Drug Administration ordered a recall of all single-entity products containing L-tryptophan. It is thought that a breakdown product of L-tryptophan, or a contaminant, is causing EMA. At 21 February 190 there had been 1305 reported cases, with 15 deaths. Patients with EMS were aged 5-84 years, and 85% were females. One third of patients had to be hospitalized. Attention is drawn to the similarity between EMS and the toxic oil syndrome that occurred in Spain in the early 1980s.
KW  - Eosinophilia
KW  - tryptophan
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of antifungal agents on the function of human neutrophils in vitro.
AU  - Roilides, E.
AU  - Walsh, T. J.
AU  - Rubin, M.
AU  - Venzon, D.
AU  - Pizzo, P. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1990///
VL  - 34
IS  - 2
SP  - 196
EP  - 201
SN  - 0066-4804
AD  - Roilides, E.: T. J. Walsh, Infectious Diseases Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901205742.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 65277-42-1, 79404-91-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - The influence of 5 antifungal agents on polymorphonuclear leukocyte (PMN) function was investigated and compared with amphotericin B (Fungizone) (AmB). The in vitro effects of AmB, flucytosine, ketoconazole, fluconazole, Sch-39304 and cilofungin (LY121019) on chemotaxis, phagocytosis, oxidative metabolism of PMN as reflected by superoxide anion (O2-) generation, and intracellular killing of Candida albicans blastoconidia were examined. With regard to chemotaxis in response to N-formylmethionyl-leucyl-phenylalanine, as measured by the multiwell chamber method, AmB induced a marked decrease (≥5 µg/ml), whereas ketoconazole at 5 µg/ml enhanced it. Phagocytosis was significantly decreased after pretreatment of PMNs with AmB and Sch-39304 (&gt;5 and 1-10 µg/ml, respectively). O2- production after stimulation of PMNs with N-formylmethionyl-leucyl-phenyl-alanine was significantly decreased by AmB (&gt;5 µg/ml) and enhanced by Sch-39304 (1-5 µg/ml). In contrast, intracellular killing, as tested by methylene blue staining, was enhanced by ketoconazole (5 µg/ml) and Sch-39304 (1-5 µg/ml). Flucytosine, fluconazole and cilofungin did not affect PMN function at therapeutic concn. It is concluded that AmB, flucytosine, cilofungin and the newer azoles, at safely achievable concn, generally do not suppress PMN function in vitro and may enhance selective functions.
KW  - Amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - Cilofungin
KW  - Fluconazole
KW  - Flucytosine
KW  - immunology
KW  - Ketoconazole
KW  - leukocytes
KW  - pharmacodynamics
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - 5-fluorocytosine
KW  - anti-fungal properties
KW  - drug action
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - killing
KW  - leucocytes
KW  - mechanism of drug action
KW  - SCH 39304
KW  - white blood cells
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.
AU  - Walsh, T. J.
AU  - Lester-McCully, C.
AU  - Rinaldi, M. G.
AU  - Wallace, J. E.
AU  - Balis, F. M.
AU  - Lee, J. W.
AU  - Pizzo, P. A.
AU  - Poplack, D. G.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1990///
VL  - 34
IS  - 6
SP  - 1281
EP  - 1284
SN  - 0066-4804
AD  - Walsh, T. J.: Section of Infectious Diseases, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901206454.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 were investigated in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body wt). The mean CSF-to-plasma area under the curve ratio was 0.63 (±0.18, standard error of the mean); max. concn were 1.34 µg/ml (±0.18) in CSF and 1.96 µg/ml (±0.43) in plasma. The mean plasma half-life was 45.7 h (±11), and mean CSF half-life was 38.7 h (±3.5). The mean levels of SCH-39304 at 24 h were 1.48 µg/ml (±0.3) in plasma and 0.96 µg/ml (±0.12) in CSF. It is concluded that SCH-39304 effectively penetrates into CSF and achieves concentrations considered active against many opportunistic yeasts and that these concentrations are sustained in CSF for ≥24 h.
KW  - Antifungal agents
KW  - pharmacokinetics
KW  - monkeys
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fungistats
KW  - SCH 39304
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits.
AU  - Walsh, T. J.
AU  - Lee, J. W.
AU  - Lecciones, J.
AU  - Kelly, P.
AU  - Peter, J.
AU  - Thomas, V.
AU  - Bacher, J.
AU  - Pizzo, P. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1990///
VL  - 34
IS  - 8
SP  - 1560
EP  - 1564
SN  - 0066-4804
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901207110.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - The potential use of SCH 39304 was investigated for the prevention and treatment of disseminated candidosis in granulocytopenic patients. Its in vivo antifungal activity as preventive, early and late treatments was studied in 3 models (acute, subacute and chronic) of disseminated Candida albicans infection in persistently granulocytopenic rabbits. SCH 39304 was as effective as amphotericin B alone and fluconazole alone for the prevention of disseminated candidosis. SCH 39304 alone and fluconazole alone were as effective as amphotericin B plus flucytosine for early treatment of subacute disseminated candidosis. When treatment was delayed for 5 d to establish chronic disseminated candidosis, SCH 39304 was less effective than amphotericin B plus flucytosine. In comparison with different treatment regimens, SCH 39304 was more effective in early and preventive treatment. SCH 39304 was comparable to treatment control regimens in prevention and early treatment of subacute disseminated candidosis.
KW  - amphotericin B
KW  - Antifungal agents
KW  - fluconazole
KW  - flucytosine
KW  - generalized infections
KW  - infections
KW  - predisposition
KW  - prophylaxis
KW  - therapy
KW  - Candida albicans
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - 5-fluorocytosine
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - SCH 39304
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits.
AU  - Lee, J. W.
AU  - Kelly, P.
AU  - Lecciones, J.
AU  - Coleman, D.
AU  - Gordee, R.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1990///
VL  - 34
IS  - 11
SP  - 2240
EP  - 2245
SN  - 0066-4804
AD  - Lee, J. W.: T. J. Walsh, Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19911207898.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 79404-91-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - The plasma pharmacokinetics and tissue penetration of cilofungin were studied by intermittent and continuous infusion in rabbits. Following a single intravenous dose of 50 mg/kg body wt, the max. concn in plasma was 297±39 µg/ml, the area under the curve was 30.1±6.7 µg.h/ml, clearance was 30±10 ml/min per kg, volume of distribution was 0.85±0.23 litres/kg, half-life in distribution phase was 3.7±0.2 min (first 12 min postdose) and half-life in elimination phase was 12.9±0.7 min. When rabbits received cilofungin by continuous infusion (CI) at 10 mg/kg per h over 6 d, sustained concn in plasma of 290±56 µg/ml were seen, &gt;50-fold higher than predicted if kinetics were linear. Similarly, at 5 mg/kg per h, high levels were also obtained. Such elevated levels in plasma would not have been predicted from the pharmacokinetic characteristics of cilofungin given as a single intravenous dose. Further pharmacokinetic studies at several rates of CI indicated that cilofungin elimination follows Michaelis-Menten kinetics. Simultaneous cilofungin levels in plasma and tissue were then determined for rabbits receiving 6 intravenous, intermittent doses (ID) of cilofungin at 15 mg/kg every 4 min and for rabbits receiving CI as described above. After ID, the mean of the ratios of cilofungin levels in tissue to those in plasma were highest for liver and bile but very low for cerebrum and cerebellum. After CI, ratios were as much as 89 times higher than for ID and significantly greater in the brain, choroid, kidney and bile (P&lt;0.05). It is concluded that following a single dose of cilofungin, the compound is rapidly cleared via first-order kinetics and does not penetrate into the central nervous system, whereas following CI, cilofungin exhibits nonlinear saturable kinetics, is slowly cleared and significantly penetrates into central nervous system tissues.
KW  - Antifungal agents
KW  - Cilofungin
KW  - pharmacokinetics
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heparin-like anticoagulant associated with systemic candidiasis.
AU  - Horne, M. K., III
AU  - Chao, E. S.
AU  - Wilson, O. J.
JO  - American Journal of Hematology
JF  - American Journal of Hematology
Y1  - 1990///
VL  - 35
IS  - 1
SP  - 37
EP  - 42
SN  - 0361-8609
AD  - Horne, M. K., III: Hematology Section, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19911208465.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 15-yr-old girl with aplastic anaemia who developed a heparin-like anticoagulant during the course of systemic Candida albicans infection. This was initially detected in the laboratory by an elevation of the thrombin clotting time which corrected with toluidine blue but not by mixing with normal plasma. In vivo and in vitro the anticoagulant was remarkably resistant to neutralization by protamine sulfate. Nevertheless, its heparin-like nature was confirmed by its sensitivity to heparinase and its dependence on antithrombin III. Despite therapy, including amphotericin B, the patient died. Post-mortem cultures of the liver yielded C. albicans.
KW  - anticoagulants
KW  - aplastic anaemia
KW  - complications
KW  - generalized infections
KW  - hosts
KW  - infections
KW  - liver
KW  - predisposition
KW  - USA
KW  - Candida albicans
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aplastic anemia
KW  - fungus
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolate-dependent differences in the oxidative metabolism of Trypanosoma cruzi epimastigotes.
AU  - Engel, J. C.
AU  - Doyle, P. S.
AU  - Dvorak, J. A.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1990///
VL  - 39
IS  - 1
SP  - 69
EP  - 76
SN  - 0166-6851
AD  - Engel, J. C.: J.A. Dvorak, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900862710.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Protozoology
N2  - Epimastigote cultures of the 2 cloned T. cruzi stocks, CA-1/72 and HO-3/15, grown under identical conditions, differed both qualitatively and quantitatively in their cytochrome content. The CA-I/72 stock has a 4-fold higher cytochrome b content (19.2 nM/mg protein) than the HO-3/15 stock (4.9 nM/mg protein). Cytochrome o is present at 29 nM/mg protein in the CA-I/72 stock but is below detectable limits in the HO-3/15 stock. There is no inter-stock difference in oxygen utilization (12-15 nM O2/min/mg protein) during exponential growth. However, stationary phase CA-I/72 epimastigotes utilize twice as much oxygen as HO-3/15 epimastigotes. Oxygen utilization by HO-3/15 epimastigotes incubated in Dulbecco's phosphate buffer solution (starvation conditions), was stimulated earlier and to higher levels by the addition of glucose than by CA-I/72 epimastigotes under identical conditions. Under starvation conditions and with the cytochrome chain partially inhibited by antimycin A, (anti-A) the addition of glucose also increased oxygen utilization by CA-I/72 epimastigotes. In contrast, anti-A did not influence glucose-stimulated oxygen utilization by HO-3/15 epimastigotes. Following partial inhibition with anti-A, salicylhydroxamic acid produced an additional 50% inhibition in oxygen utilization in both stocks irrespective of the growth phase of the organisms. These data indicate that marked intra-specific differences in oxidative metabolism exist within the T. cruzi population and that an α-glycerophosphate oxidase or similar salicylhydroxamic acid-inhibitable compound may be present in the organism.
KW  - biochemistry
KW  - cytochromes
KW  - epimastigotes
KW  - Human diseases
KW  - metabolism
KW  - parasites
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of an Onchocerca volvulus cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera.
AU  - Lobos, E.
AU  - Altmann, M.
AU  - Mengod, G.
AU  - Weiss, N.
AU  - Rudin, W.
AU  - Karam, M.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1990///
VL  - 39
IS  - 1
SP  - 135
EP  - 145
SN  - 0166-6851
AD  - Lobos, E.: Laboratory of Parasitic Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900862717.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - The primary structure of an imunodominant antigen of O. volvulus was deduced from cDNA sequence analysis. Using affinity-purified antibody from onchocerciasis patients from West Africa, a cDNA clone was isolated from a λgt11 cDNA expression library derived from microfilariae-producing female O. volvulus. The open reading frame encodes 152 amino acids, and the deduced sequence predicts a MW of 16 850 (consistent with the apparent MW of 18 000 of the immunoprecipitated in vitro translated product). The primary translation product contains a putative signal peptide of 16 amino acids. The mRNA coding for this antigen has an estimated size of 950 nucleotides. Immunoelectron microscopy established that the antigen encoded by this clone is present in the hypodermis, the cuticle, and in the uterus of the filarial worms. Since this antigen is recognized exclusively by sera from onchocerciasis patients, and not by other sera from patients infected by other filarial parasites, it may prove to be an especially valuable tool for improving the specific diagnosis of onchocerciasis.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The antigen encoded by the clone is present in the hypodermis, cuticle, and uterus of Onchocerca volvulus worms. Antibodies to the antigen were detected in sera from onchocerciasis patients from West and East Africa (but not in sera from patients infected with other filarial parasites or intestinal nematodes), suggesting its diagnostic potential.Carolyn A. Brown
KW  - antigens
KW  - complementary DNA
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - molecular genetics
KW  - parasites
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - antigenicity
KW  - biochemical genetics
KW  - cDNA
KW  - immunodominant
KW  - immunogens
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recombinant DNA probes reveal simultaneous infection of tsetse flies with different trypanosome species.
AU  - Majiwa, P. A. O.
AU  - Otieno, L. H.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1990///
VL  - 40
IS  - 2
SP  - 245
EP  - 253
SN  - 0166-6851
AD  - Majiwa, P. A. O.: National Cancer Institute, Frederick Cancer Research Facility, Bld. 539, PO Box B, Frederick, MD 21701, USA.
N1  - Accession Number: 19900863911.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The utility of recombinant DNA probes in the detection of natural trypanosome infection of tsetse flies was assessed in Lambwe Valley, near the shores of Lake Victoria, Kenya. The tsetse flies were surveyed during 2 different seasons in 1988. Three different probes used each contained highly repetitive DNA sequences specific for a species or subspecies of trypanosomes of the Nanomonas subgenus. A 4th probe contained repetitive sequences common to trypanosome species of the Trypanozoon subgenus. Mixed mature or immature infections were detected in a variety of combinations in different individual tsetse flies. Such infections were detected in both the guts and mouthparts of some tsetse flies. Simultaneous natural infection of tsetse with the savannah type Trypanosoma congolense and Kilifi type T. congolense, T. congolense and T. brucei or T. congolense and T. simiae were demonstrated. The probes were thus used to demonstrate the presence in Lambwe Valley of a type of T. congolense first observed among trypanosome isolates obtained from sentinel cattle exposed to natural infection on a ranch at Kilifi on the Kenya coast. This type of T. congolense appears not to be confined to the coastal region nor to any particular species of tsetse flies and may contribute significantly to livestock morbidity in other areas of eastern Africa. In the Kilifi area, T. congolense was found primarily in Glossina austeni; in Lambwe Valley, it was found in G. pallidipes.
KW  - chemotaxonomy
KW  - detection
KW  - disease vectors
KW  - DNA probes
KW  - Infections
KW  - Intermediate hosts
KW  - mixed infections
KW  - parasites
KW  - techniques
KW  - Vectors
KW  - Africa
KW  - Kenya
KW  - Diptera
KW  - Glossina
KW  - Glossina austeni
KW  - Glossina pallidipes
KW  - Glossinidae
KW  - Insects
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma
KW  - Trypanosoma brucei
KW  - Trypanosoma congolense
KW  - Trypanosoma simiae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Glossinidae
KW  - Diptera
KW  - Glossina
KW  - Protozoa
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Trypanosoma
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - East Africa
KW  - Africa South of Sahara
KW  - biochemical taxonomy
KW  - multiple infections
KW  - secondary hosts
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variant specific epitopes of Giardia lamblia.
AU  - Nash, T. E.
AU  - Conrad, J. T.
AU  - Merritt, J. W., Jr.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1990///
VL  - 42
IS  - 1
SP  - 125
EP  - 132
SN  - 0166-6851
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869867.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The capability of G. lamblia to express certain epitopes on the surfaces of trophozoites from different isolates and clones was determined using 4 surface-reacting monoclonal antibodies (MAbs) to variants derived from WB or WB-like Giardia (MAbs 6E7, 5C1, and 3F6) and GS/M (MAb G10/4). Of 28 isolates, 11 possessed trophozoites reactive with MAbs 6E7, 5C1 and 3F6, 6 with MAb 3F6, 2 with MAb G10/4, 1 with MAb 6E7, and 8 showed no reactivity as determined by direct or indirect immunofluorescence. Newly established clones from different isolates generated small numbers of reactive trophozoites similar to their parents. Only one epitope was found on any single trophozoite. Southern blots hybridized to a probe encoding for the epitope recognized by MAb 6E7 revealed that the inability to express the antigen in most isolates was due to lack of the gene. Analysis of the surface antigens of MAb 6E7 reactive clones from 3 isolates revealed that MAb 6E7 reacted with surface antigens of different molecular masses.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors report that among Giardia variant surface antigens the range of epitopes expressed is limited but that the same epitope may be expressed in proteins of different sizes. For example, one defined epitope was expressed in proteins of Mr 73 000, 115 000 and 120 000 in clones from a single isolate. By use of a DNA probe it was shown that a clone not expressing an epitope lacked the gene for that antigen.Further work is clearly needed and is proceeding to examine these changes and to determine their significance in relation to the role of the organism as an intestinal pathogen.S.G. Wright
KW  - antigenic variation
KW  - antigens
KW  - epitopes
KW  - Human diseases
KW  - Monoclonal antibodies
KW  - parasites
KW  - surface antigens
KW  - Giardia duodenalis
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - antigenic polymorphism
KW  - antigenicity
KW  - Giardia lamblia
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Discovery and disease control.
AU  - Miller, L. H.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1990///
VL  - 42
IS  - 3
SP  - 191
EP  - 195
SN  - 0002-9637
AD  - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900864934.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The importance of basic research, despite the fact that it may not lead to immediate solutions of major health problems, is illustrated by past successes in malaria control. The critical events that led to the discovery of antimalarials such as chloroquine, successes in mosquito control, and vaccine research are described. The need for a balanced programme of basic research, applied research and training in the USA is discussed.
KW  - Antimalarials
KW  - Antiprotozoal agents
KW  - chemical control
KW  - control
KW  - disease vectors
KW  - Human diseases
KW  - Insecticides
KW  - Malaria
KW  - Mosquito-borne diseases
KW  - parasites
KW  - research
KW  - Vaccines
KW  - Vectors
KW  - Anopheles
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Insects
KW  - Invertebrates
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - discussion
KW  - mosquitoes
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Research (AA500) 
KW  - Aquatic Biology and Ecology (MM300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recombinant capsular antigen (Fraction 1) from Yersinia pestis induces a protective antibody response in BALB/c mice.
AU  - Simpson, W. J.
AU  - Thomas, R. E.
AU  - Schwan, T. G.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1990///
VL  - 43
IS  - 4
SP  - 389
EP  - 396
SN  - 0002-9637
AD  - Simpson, W. J.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19910504715.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - Yersinia pestis produces a glycoprotein capsule, the biosynthesis of which appears to be temperature dependent. The fraction I (F1) component of this capsule is specific to Y. pestis and the detection of F1 antibodies is the basis for several serological tests. The cloning of the F1 gene and its expression in Escherichia coli using the phagemid vector λZAPII and a F1-specific monoclonal antibody are reported. The recombinant F1 antigen had a molecular weight of 17 kDa, which proved to be identical to that of the F1 antigen produced by Y. pestis. The recombinant cells produced F1 antigen at 37°C but only minimal amounts at 27°C, suggesting that the genetic features affected by temperature in Y. pestis may be operating in the E. coli clone. It is not known if their similar molecular weights reflect the glycosylated nature of both proteins. F1 antigen purified from the E. coli recombinant induced a protective immune response in BALB/c mice challenged with up to 105 virulent Y. pestis. The resistance of immunized mice to plague infection correlated with high titres of F1 antibody. The cloned gene expresses an immunogenically competent F1 antigen suitable for use in plague serodiagnostics and vaccine development.
KW  - Antibodies
KW  - antigens
KW  - Bacterial diseases
KW  - Biotechnology
KW  - Clones
KW  - Gene expression
KW  - Genes
KW  - Glycoproteins
KW  - immune response
KW  - immunization
KW  - Immunodiagnosis
KW  - Plague
KW  - Vaccines
KW  - mice
KW  - Yersinia pestis
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - recombinant capsular antigen
KW  - serological diagnosis
KW  - YERSINIA PSEUDOTUBERCULOSIS SUBSP. PESTIS
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body mass index and 15-year mortality in a cohort of black men and women.
AU  - Weinpahl, J.
AU  - Ragland, D. R.
AU  - Sidney, S.
JO  - Journal of Clinical Epidemiology
JF  - Journal of Clinical Epidemiology
Y1  - 1990///
VL  - 43
IS  - 9
SP  - 949
EP  - 960
SN  - 0895-4356
AD  - Weinpahl, J.: National Institute on Aging, Epidemiology, Demography and Biometry Program, Federal Building, Room 618, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911433285.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Human Nutrition
N2  - The association between body mass index (BMI) and mortality was studied in 2453 black men, 30 to 79 years old, and 2731 black women, 40 to 79 years old, in California, USA, all members of the Kaiser Foundation Health Plan, a pre-paid health maintenance organization. During a 15-year follow-up 393 men and 283 women died. Separate effects of low weight and high weight on mortality were isolated. Potential bias from cigarette smoking and antecedent illness was noted. Cox regression analyses showed that over the entire range of BMI the adjusted BMI-mortality association was significantly J-shaped for men and flat for women. The inverse association between BMI and mortality in the lower range of BMI was significant for men; the adjusted relative hazard increasing from the 10th to the 50th percentile of BMI was 0.76 (95% confidence interval (CI) 0.59 to 0.98). The positive association between BMI and mortality in the upper range of BMI was highly significant for men; the adjusted relative hazard increasing from the 50th to the 90th percentile of BMI was 1.37 (95% CI 1.14 to 1.63). Smoking and antecedent illness did not have an impact on the BMI-mortality association in either sex.
KW  - body measurements
KW  - Ethnic groups
KW  - mortality
KW  - California
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - death rate
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433285&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Validation of a self-administered diet history questionnaire using multiple diet records.
AU  - Block, G.
AU  - Woods, M.
AU  - Potosky, A.
AU  - Clifford, C.
JO  - Journal of Clinical Epidemiology
JF  - Journal of Clinical Epidemiology
Y1  - 1990///
VL  - 43
IS  - 12
SP  - 1327
EP  - 1335
SN  - 0895-4356
AD  - Block, G.: National Cancer Institute, Executive Plaza North, Room 313, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911433291.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - The validity of a self-administered diet history questionnaire was estimated using as reference data the mean of 3 4-day diet records collected during the year before the questionnaire was given in 1985-86. Subjects were 260 women, 45 to 70 years old, who participated in the Women's Health Trial Feasibility Study, a multi-centre clinical trial in the USA, in which some women took a diet low in fat and others maintained their normal diet. The questionnaire produced group mean nutrient estimates close to values obtained by 4-day records, e.g. in those on normal diet, 37.7% of energy from fat by food records and questionnaire and in the low-fat group, 21.3% of energy from fat by food records and 23.7% of energy from fat by questionnaire. Correlations between questionnaire and diet records for percentage of energy were 0.67 and 0.65, respectively, in the 2 groups. Most correlations were in the range 0.5 to 0.6 and were similar to that achieved by a single 4-day food record.
KW  - Diet study techniques
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433291&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The generation of genetic diversity in malaria parasites.
AU  - McConkey, G. A.
AU  - Waters, A. P.
AU  - McCutchan, T. F.
JO  - Annual Review of Microbiology
JF  - Annual Review of Microbiology
Y1  - 1990///
VL  - 44
SP  - 479
EP  - 498
SN  - 0066-4227
AD  - McConkey, G. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920883148.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Subject Subsets: Protozoology
N2  - This review focuses on the generation of diversity in Plasmodium falciparum and its implications with regard to the parasite's potential for dealing with variables in its environment such as immune and drug pressure. Major headings include: the P. falciparum chromosome ; chromosomal polymorphism ; gene duplication; repetitive sequences in the surface antigen genes; point mutations and selection; parasites under pressure.
KW  - antigens
KW  - chromosomes
KW  - evolution
KW  - genetic variation
KW  - malaria
KW  - parasites
KW  - polymorphism
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - antigenicity
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Age- and sex-dependent stimulation of calcium uptake in duodenal cells by prolactin in vitamin D-deficient rats.
AU  - Balakir, R. A.
AU  - Cheng, L.
AU  - Sacktor, B.
AU  - Liang, C. T.
JO  - Life Sciences
JF  - Life Sciences
Y1  - 1990///
VL  - 47
IS  - 1
SP  - 77
EP  - 83
SN  - 0024-3205
AD  - Balakir, R. A.: C. T. Liang, Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19921448183.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 7440-70-2, 9002-62-4, 1406-16-2.  Subject Subsets: Human Nutrition
N2  - Administration of ovine-prolactin (O-PRL) stimulated Ca2+ uptake in isolated duodenal cells prepared from vitamin D-deficient rats. The time course of this effect was biphasic: uptake activity reached a peak in 2.5 h followed by a decrease at 5 h to original values. This stimulatory effect of O-PRL was observed in vitamin D-deficient male, but not in female rats. This stimulatory effect was observed in rats 16 and 26 but not 9 weeks old. Increase in Ca2+ uptake in duodenal cells was not due to a decrease in intracellular Ca2+ efflux. Serum calcium increased in deficient female rats between 16 and 52 weeks whereas a minimal increase was observed in deficient male rats. Although prolactin was shown to stimulate duodenal Ca2+ uptake, it seems that the source of the increase in serum Ca in deficient female rats was not derived from an increase in Ca2+ uptake by prolactin in duodenum. The increase in serum Ca with time may explain why female vitamin D-deficient rats survive longer than male.
KW  - calcium
KW  - deficiency
KW  - duodenum
KW  - prolactin
KW  - uptake
KW  - Vitamin D
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - lactogenic hormone
KW  - mammotropin
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448183&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin A prophylaxis programs in developing countries: past experiences and future prospects.
AU  - Underwood, B. A.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1990///
VL  - 48
IS  - 7
SP  - 265
EP  - 274
SN  - 0029-6643
AD  - Underwood, B. A.: International Program Activities, National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901451726.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Registry Number: 68-26-8.  Subject Subsets: Horticultural Science; Human Nutrition; Tropical Diseases
N2  - Clinical eye signs are estimated to affect 5 to 10 million children annually in the developing world. Thus, most experience with large-scale prophylaxis programmes has been with periodic distribution of high-dose vitamin A supplements directed toward preventing ocular problems. However, subclinical vitamin A depletion affects an estimated five- to tenfold larger population, and evidence is accumulating for a subclinical protective role of vitamin A against risk of mortality and, perhaps, morbidity. Current programmes aim to integrate prophylaxis with vitamin A supplements into ongoing programmes. Decentralization of distribution of supplements and their integration into community-based programmes require careful consideration of dosages and frequency to assure safety and broad coverage. Fortification of foods and condiments has not provided adequate prophylaxis in countries with significant vitamin A deficiency. Other strategies recognized as more sustainable, long-term solutions have received less attention, and their potential has not been evaluated. Such strategies aim to increase dietary intake of vitamin A or decrease physiological requirements or both: these strategies include horticulture, public health, socioeconomic improvement and nutrition and health education measures.
KW  - children
KW  - deficiency
KW  - eye diseases
KW  - nutrition
KW  - prophylaxis
KW  - Retinol
KW  - supplements
KW  - vitamins
KW  - Developing countries
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - countries
KW  - A
KW  - axerophthol
KW  - supplementation programmes
KW  - Third World
KW  - Underdeveloped Countries
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum vitamin A and subsequent development of prostate cancer in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study.
AU  - Reichman, M. E.
AU  - Hayes, R. B.
AU  - Ziegler, R. G.
AU  - Schatzkin, A.
AU  - Taylor, P. R.
AU  - Kahle, L. L.
AU  - Fraumeni, J. F., Jr.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1990///
VL  - 50
IS  - 8
SP  - 2311
EP  - 2315
SN  - 0008-5472
AD  - Reichman, M. E.: National Cancer Institute, NIH, 9000 Rockville Pike, EPN 211, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931453824.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - The relation between serum vitamin A measurements made at baseline examination (1971-75) and subsequent development of prostate cancer was examined in the USA, National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study (1981-1984). The analytic cohort consisted of 2440 men 50 years old or older who were followed for a median of 10 years. A total of 84 men developed prostate cancer. The mean level of serum vitamin A was significantly lower in prostate cancer than in controls. As a continuous variable or in quartiles, a significant trend was observed for increased risk of prostate cancer with decreasing serum vitamin A. Adjusted for age and race, men in the lowest quartile had a relative risk of 2.2 (95% confidence intervals 1.1, 4.3) compared with those in the highest quartile. The increased risk of prostate cancer associated with the lowest quartile of serum vitamin A did not attenuate with increasing time between blood drawing and diagnosis, suggesting that metabolic effects of early disease are an unlikely explanation of these results. The inverse association between serum vitamin A and prostate cancer incidence was independent of age at examination and several other possible confounding variables.
KW  - Blood
KW  - Carcinoma
KW  - Prostate
KW  - Retinol
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Human Nutrition (General) (VV100) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931453824&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A case-control study of diet and benign proliferative epithelial disorders of the breast.
AU  - Rohan, T. E.
AU  - Cook, M. G.
AU  - Potter, J. D.
AU  - McMichael, A. J.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1990///
VL  - 50
IS  - 11
SP  - 3176
EP  - 3181
SN  - 0008-5472
AD  - Rohan, T. E.: National Cancer Institute of Canada Epidemiology Unit, McMurrich Building, 3rd Floor, University of Toronto, Toronto, Ont. M5S 1A8, Canada.
N1  - Accession Number: 19911453938.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - Benign proliferative epithelial disorders (BPED) of the breast are conditions which, although not proven precursors of breast cancer, are strongly associated with increased risk of this disease. In a case-control study in Adelaide, South Australia, the association between dietary factors and risk of BPED was investigated. The study involved 383 cases of biopsy-confirmed BPED, 192 controls whose biopsy did not show epithelial proliferation and 383 unbiopsied community controls matched to cases on age and area of residence. When cases were compared with community controls, there was little variation in the risk of BPED across amounts of daily intake of energy, protein and fat, but there was some suggestion of inverse associations with daily intake of retinol, β-carotene and fibre; in contrast, with biopsy controls as the comparison group, risk of BPED increased with increasing energy and fat intake but varied little with retinol, βcarotene and fibre intake. Results provide additional evidence against roles for dietary energy and fat intake in the aetiology of breast cancer. However, further studies of diet and BPED should be conducted in populations surveyed cross-sectionally for breast changes, in an attempt to limit or avoid the selection and misclassification biases to which studies of putative precursor lesions are susceptible.
KW  - Carcinoma
KW  - diets
KW  - mammary glands
KW  - Australia
KW  - South Australia
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - Australia
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Undernutrition among Bedouin Arab infants: the Bedouin Infant Feeding Study.
AU  - Forman, M. R.
AU  - Guptill, K. S.
AU  - Chang, D. N.
AU  - Sarov, B.
AU  - Berendes, H. W.
AU  - Naggan, L.
AU  - Hundt, G. L.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1990///
VL  - 51
IS  - 3
SP  - 343
EP  - 349
SN  - 0002-9165
AD  - Forman, M. R.: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, 6130 Executive Plaza North Room 211, Rockville, MD 20892, USA.
N1  - Accession Number: 19901425707.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Human Nutrition; Tropical Diseases
N2  - In 1981, 274 healthy newborn Bedouin Arab infants in the Negev, Israel, were followed for 18 months to examine the relation between infant-feeding practices and growth during planned social change. Although wasting was not prevalent, the prevalence rate of stunting (≤-2 s.d.) increased from 12 to 19 to 32% at 6, 12 and 18 months, respectively. After multiple-logistic-regression adjustment for covariates, the odds ratio (OR) of stunting at 6 months was reduced among infants breast-fed only or fed with supplement compared with weaned infants. Infant-feeding practices were not associated with stunting in later infancy; those stunted at 6 months had an OR of 13 of stunting at 12 months and those stunted at 12 months had an OR of 14 of stunting at 18 months. In a multiple-linear-regression analysis, seasonality, duration of breast-feeding, hospitalized morbidity and residual of height at 6 months were negatively associated with daily average linear growth from 6 to 12 months; these factors only explained 12% of the variation in daily linear growth.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Two hundred seventy-four healthy Bedouin Arab newborns in 1981 were followed for 18 mo to examine the relationship between infant-feeding practices and growth during planned social change. Although wasting was not prevalent, the prevalence rate of stunting (≤-2 SDs) increased from 12% to 19% to 32% at 6, 12, and 18 mo, respectively. After multiple-logistic-regression adjustment for covariates, the odds ratio (OR) of stunting at 6 mo was reduced among infants breast-fed only or fed with supplement compared with weaned infants. Infant-feeding practices were not associated with stunting in later infancy; however, those stunted at 6 mo had an OR of 13 of stunting at 12 mo and those stunted at 12 mo had an OR of 14 of stunting at 18 mo. In a multiple-linear-regression analysis, seasonality, duration of breast-feeding, hospitalized morbidity, and residual of height at 6 mo were negatively associated with daily average linear growth from 6 to 12 mo; these factors only explained 12% of the variation in daily linear growth.AS
KW  - children
KW  - ethnic groups
KW  - feeding
KW  - growth
KW  - Infants
KW  - Nutrition
KW  - nutritional state
KW  - Asia
KW  - Israel
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - West Asia
KW  - Asia
KW  - Bedouin
KW  - nutritional status
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary vitamin B-6 intake and food sources in the US population: NHANES II, 1976-1980.
AU  - Kant, A. K.
AU  - Block, G.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1990///
VL  - 52
IS  - 4
SP  - 707
EP  - 716
SN  - 0002-9165
AD  - Kant, A. K.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19911428782.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 65-23-6.  Subject Subsets: Human Nutrition; Potatoes
N2  - Dietary vitamin B6 intake and food sources were estimated from the Second National Health and Nutrition Examination Survey (NHANES II) dietary data for 11658 adults 19 to 74 years old in the USA. The average daily intake of vitamin B6 was 1.48±0.01 mg (mean±s.e.m.) for the total population, 1.85±0.02 for men and 1.14±0.01 for women. Of men 71 and women 90% consumed less than the 1980 recommended dietary allowance (RDA) of vitamin B6. Of all survey respondents 64% reported a ratio of vitamin B6 to dietary protein of &lt;0.02 (expressed as mg/g protein). Foods from animal and plant sources provided 48 and 52% of the total vitamin B6, respectively. Vitamin B6 intake decreased with increasing age and decreasing education and income status. Beef steaks and roasts, alcoholic beverages, potatoes, ready-to-eat cereals and milk were important dietary sources of vitamin B6.
KW  - intake
KW  - Nutrition
KW  - Pyridoxine
KW  - sources
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911428782&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Breast cancer and dietary and plasma concentrations of carotenoids and vitamin A.
AU  - Potischman, N.
AU  - McCulloch, C. E.
AU  - Byers, T.
AU  - Nemoto, T.
AU  - Stubbe, N.
AU  - Milch, R.
AU  - Parker, R.
AU  - Rasmussen, K. M.
AU  - Root, M.
AU  - Graham, S.
AU  - Campbell, T. C.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1990///
VL  - 52
IS  - 5
SP  - 909
EP  - 915
SN  - 0002-9165
AD  - Potischman, N.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911429887.  Publication Type: Journal Article.  Language: English.  Number of References: 61 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - A case-control study of breast cancer was made in Buffalo, New York, USA. Participants completed a food frequency questionnaire and donated a fasting blood sample before definitive workup for breast masses. Dietary and plasma concentrations of carotenoids and retinol for 83 women found to have breast cancer were compared with those of 113 women free of breast cancer (control subjects). There were no case-control differences in dietary estimates of retinol intake or in plasma α-carotene and lycopene. However, subjects with breast cancer had lower concentrations of plasma β-carotene than did controls (P = 0.02). There was no overall association between plasma retinol and breast cancer but a positive relation was observed between retinol and breast cancer in the subgroup with low β-carotene values. These results suggest that low plasma β-carotene is associated with increased risk of breast cancer. Other studies will need to determine whether low carotene concentrations are a subtle effect of the disease or might be causally related to breast cancer.
KW  - blood
KW  - Carcinoma
KW  - carotenoids
KW  - diets
KW  - mammary glands
KW  - retinol
KW  - New York
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - tetraterpenoids
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429887&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Novel dialkylpiperidines in the venom of the ant Monomorium delagoense.
AU  - Jones, T. H.
AU  - Blum, M. S.
AU  - Robertson, H. G.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1990///
VL  - 53
IS  - 2
SP  - 429
EP  - 435
SN  - 0163-3864
AD  - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung and Blood Institute, Betheseda, MD 20892, USA.
N1  - Accession Number: 19920512685.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - New dialkylpiperidines, including cis- and trans-2,6-di(4-pentenyl)-piperidine, cis- and trans-2-(4-pentenyl)-6-pentylpiperidine, and cis- and trans-2-(6-heptenyl)-6-(4-pentenyl)-piperidine were detected in the venom of the southern African ant M. delagoense by gas chromatography/mass spectrometry. The structures of these compounds (which were shown to possess insecticidal and repellent properties) were confirmed by synthesis.
KW  - biochemistry
KW  - Insecticidal properties
KW  - Molecular conformation
KW  - Piperidines
KW  - Repellency
KW  - Toxins
KW  - venoms
KW  - Formicidae
KW  - Hymenoptera
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Monomorium
KW  - Formicidae
KW  - Monomorium delagoense
KW  - Social insecs
KW  - Toxinology
KW  - venom
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920512685&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus.
AU  - Beutler, J. A.
AU  - Alvarado, A. B.
AU  - Schaufelberger, D. E.
AU  - Andrews, P.
AU  - McCloud, T. G.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1990///
VL  - 53
IS  - 4
SP  - 867
EP  - 874
SN  - 0163-3864
AD  - Beutler, J. A.: Developmental Therapeutics Program, National Cancer Institute, NCI-FCRDC, Frederick, MD 21702, USA.
N1  - Accession Number: 19900399736.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Horticultural Science
N2  - The phorbol dibutyrate receptor binding assay is used to identify organisms containing bioactive substances. The process of rapidly identifying known chemotypes is termed dereplication in the antibiotics field. C. cuneatus leaves and the marine blue-green alga L. majuscula were used as prototypes for the dereplication of phorbol ester receptor binding activity. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in Croton.
KW  - composition
KW  - medicinal plants
KW  - Croton
KW  - Euphorbiaceae
KW  - Euphorbiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Lyngbya
KW  - Cyanobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - Croton cuneatus
KW  - drug plants
KW  - Lyngbya majuscula
KW  - medicinal herbs
KW  - officinal plants
KW  - plant
KW  - Plant Composition (FF040) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever.
AU  - Vishwanath, S.
AU  - McDonald, G. A.
AU  - Watkins, N. G.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 3
SP  - 646
EP  - 653
SN  - 0019-9567
AD  - Vishwanath, S.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515396.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - There are no vaccines against boutonneuse fever or Rocky Mountain spotted fever. Previous studies identified a R. rickettsii surface protein as a vaccine candidate and showed that an antigenically related protein is present in R. conorii. The gene encoding the R. rickettsii protein was cloned and expressed in Escherichia coli. By using 7.5% SDS-PAGE of rickettsial lysates followed by immunoblotting with a monoclonal antibody raised against the R. rickettsii protein it was confirmed that an analogous protein exists in R. conorii. Although these proteins were previously called 155-kDa proteins, their apparent molecular masses were 198 kDa for R. conorii Kenya tick typhus (KTT) and 190 kDa for R. rickettsii. Using the R. rickettsii gene probe, a 5.5-kb HindIII fragment from R. conorii KTT genomic DNA was cloned and expressed in E. coli JM107. The expressed recombinant product was recognized by a monospecific polyclonal rabbit antiserum prepared against the 198-kDa protein. Guineapigs immunized with sonic lysates of the E. coli strain expressing the recombinant gene product developed antibodies recognizing R. conorii when tested by a microimmunofluorescence antibody assay. Upon immunoblotting of rickettsial lysates, those antisera specifically recognized the 198-kDa R. conorii protein and its 190-kDa analogue in R. rickettsii. Guineapigs immunized with sonic lysates of the recombinant E. coli expressing the 198-kDa protein were protected from experimental infections with the homologous R. conorii strain and partially protected from experimental infections with a strain of the heterologous species R. rickettsii. These findings show that the 198-kDa R. conorii protein is a candidate for a vaccine against boutonneuse fever.
KW  - DNA
KW  - Genes
KW  - immunization
KW  - Laboratory animals
KW  - Recombinant vaccines
KW  - Rickettsial diseases
KW  - vaccines
KW  - Escherichia coli
KW  - guineapigs
KW  - Rickettsia conorii
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - bacterium
KW  - Cloning
KW  - deoxyribonucleic acid
KW  - E. coli
KW  - guinea pigs
KW  - immune sensitization
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Borrelia burgdorferi contains repeated DNA sequences that are species specific and plasmid associated.
AU  - Simpson, W. J.
AU  - Garon, C. F.
AU  - Schwan, T. G.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 4
SP  - 847
EP  - 853
SN  - 0019-9567
AD  - Simpson, W. J.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515476.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia burgdorferi contains linear and supercoiled circular (SC) plasmids. Because SC plasmids are present in multiple copies, these plasmids were examined for species-specific sequences that could serve as high-copy-number target DNAs for a diagnostic probe. 3 EcoRI fragments (4.3, 4.2 and 3.5 kb pairs) that hybridized with multiple DNA fragments from B. burgdorferi were identified and cloned from a SC plasmid-enriched fraction. The 4.2- and 3.5-kb fragments were similar in that they hybridized with each other and with similar-sized EcoRI fragments from 2 unrelated strains of B. burgdorferi. The 4.3-kb fragment did not hybridize with the other 2 cloned sequences. Both types of sequences hybridized with most of the SC plasmids in 7 B. burgdorferi isolates, whereas only a single 49-kb linear plasmid, found in 2 of the 7 strains tested, hybridized with the cloned sequences. None of the cloned sequences hybridized with chromosomal DNA from B. burgdorferi or with total DNA or SC plasmids from Borrelia hermsii, B. turicatae, B. coriaceae, B. parkeri or B. anserina. These data indicate that the repeated DNA sequences described in this study appear to be plasmid associated and specific to B. burgdorferi. Heteroduplexes formed from the 4.2- and 3.5-kb fragments showed that hybridizing regions in each fragment comprise a 1.8-kb conserved region that is adjacent to a 1.5-kb region that exhibits greater sequence variability. The sequence divergence seen in the variable region is likely the result of genetic drift and may mean that these regions represent closely related genes that encode functionally similar but antigenically distinct proteins.
KW  - DNA
KW  - DNA hybridization
KW  - DNA probes
KW  - Genes
KW  - molecular genetics
KW  - Nucleotide sequences
KW  - Plasmids
KW  - Borrelia anserina
KW  - Borrelia burgdorferi
KW  - Borrelia coriaceae
KW  - Borrelia hermsii
KW  - Borrelia parkeri
KW  - Borrelia turicatae
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - Repeat DNA
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 
TY  - JOUR
T1  - Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease.
AU  - Gazzinelli, R. T.
AU  - Leme, V. M. C.
AU  - Cançado, J. R.
AU  - Gazzinelli, G.
AU  - Scharfstein, J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 5
SP  - 1437
EP  - 1444
SN  - 0019-9567
AD  - Gazzinelli, R. T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910871966.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - T. cruzi antigenic specificities involved in human T-cell and antibody responses were compared in chronic chagasic patients affected with cardiomyopathy (C) or with the indeterminate form (I), the asymptomatic form of Chagas' disease. T-cell Western blotting (immunoblotting) was performed to identify the most active antigens in epimastigote extracts (EPI-Ag). The patterns of peripheral blood mononuclear cell (PBMC) and T-cell proliferative responses induced by fractions blotted to nitrocellulose were heterogeneous, but the computation of their frequency distribution disclosed some important antigen specificities. Molecules ranging from 100 000, 150 000 MW were frequently stimulatory to PBMC from I patients (5 of 8 cases) and were less so when confronted with C patient (1 of 7 cases) lymphocytes. In contrast, both groups of patients actively responded to fractions ranging from 48 000 to 57 000 and 28 000 to 32 000 MW. The Western immunoblotting patterns of antibody reactivity displayed by 17 C and 15 I patients were also similar, yielding outstanding staining in the MW ranges of 70 000 to 80 000 and 43 000 to 57 000 MW. The latter antigen complex was recognized by 100% of the 32 chronic Chagas' disease serum specimens tested and closely corresponded to the migratory position recognized by T cells of most patients tested. The identification of the active molecules contained in the 43 000 to 57 000 MW region was sought, with a focus on GP57/51, an antigen with well-established serodiagnostic properties. Immunoblotting analysis of EPI-Ag with a monoclonal antibody to GP57/51 confirmed its presence within the predicted MW region. Highly purified GP51 was then used to demonstrate directly its capacity to promote specific PBMC proliferative responses in vitro. Data computed from a survey with 12 patients showed a linear correlation (r = 0.93) between PBMC responses to EPI-Ag and to purified GP51, suggesting that the immune response to this particular glycoprotein may be an important component of human immune responses against T. cruzi.
KW  - antibodies
KW  - antigens
KW  - Chagas' disease
KW  - glycoproteins
KW  - Human diseases
KW  - immune response
KW  - immunity
KW  - parasites
KW  - responses
KW  - T lymphocytes
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of Pneumocystis carinii chromosomes and mapping of five genes.
AU  - Lundgren, C.
AU  - Cotton, R.
AU  - Lundgren, J. D.
AU  - Edman, J. C.
AU  - Kovacs, J. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 6
SP  - 1705
EP  - 1710
SN  - 0019-9567
AD  - Lundgren, C.: J. A. Kovacs, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872282.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Protozoology
N2  - Pulsed field gel electrophoresis was used to identify the chromosome-size DNA of P. carinii. Thirteen chromosomes of rodent P. carinii, ranging in size from 300 to 700 kilobases (kb), were identified. The minimum genome size for P. carinii, estimated on the basis of the sizes of chromosomes, is 7000 kb. Genetic heterogeneity among different P. carinii isolates was documented by demonstration of chromosomal size variability. By hybridization studies, the genes for topoisomerase I, dihydrofolate reductase, rRNA, actin, and thymidylate synthase were mapped to single chromosomes of approximately 650, 590, 550, 460, and 350 kb, respectively. Hybridization studies further confirmed the genetic heterogeneity of P. carinii.
KW  - chromosomes
KW  - Human diseases
KW  - molecular genetics
KW  - parasites
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Rodents
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - biochemical genetics
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Galβ1-4Glcβ1-1Cer), a possible adhesion receptor for yeasts.
AU  - Jimenez-Lucho, V.
AU  - Ginsburg, V.
AU  - Krivan, H. C.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 7
SP  - 2085
EP  - 2090
SN  - 0019-9567
AD  - Jimenez-Lucho, V.: H. C. Krivan, Laboratory of Structural Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901206594.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The role of glycosphingolipids as adhesion receptors for yeasts was examined. Cryptococcus neoformans, Candida albicans and Saccharomyces cerevisiae, as well as Histoplasma capsulatum and Sporotrichum [Sporothrix] schenckii (in their yeast phases), bound specifically to lactosylceramide (Galβ1-4Glcβ1-1Cer), as measured by overlaying glycosphingolipid chromatograms with 125I-labelled organisms. An unsubstituted galactosyl residue was required for binding, because the yeasts did not bind to glucosylceramide (G1cβ1-1Cer) derived from lactosylceramide by treatment with β-galactosidase or to other neutral or acidic glycosphingolipids tested that contained internal lactosyl residues. The yeasts preferentially bound to the upper band of the lactosylceramide doublet in human lung and bovine erythrocytes, indicating that the ceramide structure also affects binding. Active metabolism of the yeasts was required for binding to lactosylceramide, as binding was maximal in buffer containing glucose and was almost completely abolished in nutrient-deficient medium. Cryptococcus neoformans also bound to human glioma brain cells grown in monolayers and this binding was inhibited by liposomes containing lactosylceramide but not by liposomes containing glucosylceramide. Lactosylceramide is a major glycosphingolipid in these cells and the only one to which the yeasts bound. It is concluded that since lactosylceramide is widely distributed in epithelial tissues, this glycosphingolipid may be the receptor for yeast colonization and disseminated disease in humans.
KW  - adhesion
KW  - Candida albicans
KW  - Cryptococcus neoformans
KW  - Histoplasma capsulatum
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Sporothrix schenckii
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Sporothrix
KW  - Ophiostomataceae
KW  - Ophiostomatales
KW  - Sordariomycetes
KW  - Ajellomyces capsulatus
KW  - fungus
KW  - Hyphomycetes
KW  - lactosylceramide
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence that Candida stellatoidea type II is a mutant of Candida albicans that does not express sucrose-inhibitable α-glucosidase.
AU  - Kwon-Chung, K. J.
AU  - Hicks, J. B.
AU  - Lipke, P. N.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 9
SP  - 2804
EP  - 2808
SN  - 0019-9567
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19901207059.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 9001-42-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - It was shown that sucrose-positive revertants of C. stellatoidea type II are readily isolated and that C. stellatoidea type II strs. probably resulted from a mutation of the sucrase gene of C. albicans. The revertants were not laboratory contaminants, as determined by restriction fragment length polymorphism analysis and retention of an auxotrophic marker. The reversion of 3 tested strs. was accompanied by 16- to 110-fold increases in expression of a sucrase/α-glucosidase but not an invertase, with a Kmfor sucrose of about 1 mM. The enzyme activity was assayable in intact cells. It is suggested that the drastically increased expression of such an enzyme would allow extracellular sucrose hydrolysis and assimilation of the monosaccharide products.
KW  - alpha-glucosidase
KW  - enzymes
KW  - genetics
KW  - mutants
KW  - physiology
KW  - taxonomy
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - alpha-D-glucosidase
KW  - Candida stellatoidea
KW  - fungus
KW  - Hyphomycetes
KW  - maltase
KW  - systematics
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunization of mice against Plasmodium vinckei with a combination of attenuated Salmonella typhimurium and malarial antigen.
AU  - Kumar, S.
AU  - Gorden, J.
AU  - Flynn, J. L.
AU  - Berzofsky, J. A.
AU  - Miller, L. H.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 10
SP  - 3425
EP  - 3429
SN  - 0019-9567
AD  - Kumar, S.: L.H. Miller, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910871559.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology
N2  - Infection with the blood stage of P. vinckei is uniformly lethal in mice. It was found that immunization of BALB/c mice with a combination of killed P. vinckei antigens and an attenuated (aroA) S. typhimurium strain induced high levels of protection against challenge with live P. vinckei. This is especially significant because, in previous studies, immunization of mice with killed P. vinckei antigens and adjuvants such as Bordetella pertussis, complete Freund adjuvant, and saponin failed to induce protective immunity. Immunization with attenuated S. typhimurium alone did not provide any nonspecific immunity. In vivo depletion of CD4+ T cells in the mice immunized with attenuated S. typhimurium and P. vinckei antigens caused the loss of their immunity. Expression of this immunity required the presence of a spleen. These results support a previous hypothesis that a blood stage malaria vaccine may need both induction of CD4+ T cells specific for the parasite and modification of the spleen with a vaccine vehicle. Therefore, attenuated Salmonella strains such as the one used in this study, when expressing recombinant malarial antigens, might fulfill this requirement.
KW  - combined vaccines
KW  - Human diseases
KW  - immunization
KW  - Laboratory animals
KW  - parasites
KW  - Spleen
KW  - T lymphocytes
KW  - Vaccines
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium vinckei
KW  - protozoa
KW  - Rodents
KW  - Salmonella typhimurium
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - immune sensitization
KW  - mixed vaccines
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a monoclonal antibody that selectively recognizes a subset of Entamoeba histolytica isolates.
AU  - Bhattacharya, A.
AU  - Ghildyal, R.
AU  - Bhattacharya, S.
AU  - Diamond, L. S.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1990///
VL  - 58
IS  - 10
SP  - 3458
EP  - 3461
SN  - 0019-9567
AD  - Bhattacharya, A.: L.S. Diamond, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910871560.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Protozoology
N2  - An MAb (2D7.10) recognized an antigen present in 7 of 9 isolates of axenically cultured E. histolytica and absent in all other Entamoeba isolates studied. The antigen was absent in 2 isolates: 200:NIH and Rahman. All 9 isolates belonged to pathogenic zymodeme II. Western blot (immunoblot) analysis and treatment with periodate and the proteolytic enzyme trypsin suggest that the antigen recognized by 2D7.10 is a carbohydrate moiety.
KW  - antigens
KW  - Human diseases
KW  - Immunotaxonomy
KW  - monoclonal antibodies
KW  - parasites
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selenium biochemistry.
AU  - Stadtman, T. C.
JO  - Annual Review of Biochemistry
JF  - Annual Review of Biochemistry
Y1  - 1990///
VL  - 59
SP  - 111
EP  - 127
SN  - 0066-4154
AD  - Stadtman, T. C.: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921445012.  Publication Type: Journal Article.  Language: English.  Number of References: 97 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
N2  - Developments in selenium biochemistry since 1980 are reviewed. The main topics considered are (1) selenoenzymes that contain selenocysteine (bacterial enzymes apart from mammalian glutathione peroxidase), (2) mammalian selenoproteins, (3) bacterial selenoenzymes that do not contain selenocysteine, (4) seleno-tRNAs and (5) incorporation of selenocysteine into proteins in prokaryotes and eukaryotes. Consideration is also given to some additional aspects of selenium containing enzymes and other compounds in prokaryotes.
KW  - biochemistry
KW  - reviews
KW  - Selenium
KW  - Physiology of Human Nutrition (VV120) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - The duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites.
AU  - Adams, J. H.
AU  - Hudson, D. E.
AU  - Torii, M.
AU  - Ward, G. E.
AU  - Wellems, T. E.
AU  - Aikawa, M.
AU  - Miller, L. H.
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1990///
VL  - 63
IS  - 1
SP  - 141
EP  - 153
SN  - 0092-8674
AD  - Adams, J. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874336.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Protozoology
N2  - P. vivax and P. knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. A soluble parasite protein of 135 000 MW binds specifically to a human Duffy antigen. Using antisera affinity purified on the 135 000 MW protein, a gene was cloned that encodes a member of a P. knowlesi family of erythrocyte binding proteins. The gene is a member of a family that includes 3 homologous genes located on separate chromosomes. Two genes are expressed as major membrane-bound products that give rise to soluble erythrocyte binding proteins: the 135 000 MW Duffy binding protein and a 138 000 MW protein that binds only rhesus erythrocytes. These different erythrocyte binding specificities may result from sequence divergence of the homologous genes. The Duffy receptor family was found to be localized in micronemes of late schizonts and free merozoites.
KW  - Biochemistry
KW  - Developmental stages
KW  - genes
KW  - merozoites
KW  - Molecular genetics
KW  - parasites
KW  - proteins
KW  - Apicomplexa
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - Duffy binding protein
KW  - erythrocyte binding proteins
KW  - growth phase
KW  - micronemes
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Equine infectious anemia virus tat: insights into the structure, function, and evolution of lentivirus trans-activator proteins.
AU  - Dorn, P.
AU  - DaSilva, L.
AU  - Martarano, L.
AU  - Derse, D.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1990///
VL  - 64
IS  - 4
SP  - 1616
EP  - 1624
SN  - 0022-538X
AD  - Dorn, P.: D. Derse, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013, USA.
N1  - Accession Number: 19902210002.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - Equine infectious anaemia virus (EIAV) contains a tat gene which is closely related to the trans-activator genes of the human and simian immunodeficiency viruses. Nucleotide sequence analysis of EIAV cDNA clones showed that the tat mRNA is composed of three exons; the first two encode Tat and the third may encode a Rev protein. Interestingly, EIAV Tat translation is initiated at a non-AUG codon in exon 1 of the mRNA, perhaps allowing an additional level of gene regulation. The deduced amino acid sequence of EIAV tat, combined with functional analyses of tat cDNAs in transfected cells, has provided some unique insights into the domain structure of Tat. EIAV Tat has a C-terminal basic domain and a highly conserved 16-amino-acid core domain, but not the cysteine-rich region, that are present in the primate immunodeficiency virus Tat proteins. Thus, EIAV encodes a relatively simple version of this kind of trans activator.
KW  - Amino acids
KW  - Gene expression
KW  - Genes
KW  - horse diseases
KW  - Messenger RNA
KW  - Molecular biology
KW  - nucleotide sequences
KW  - Structure
KW  - viral diseases
KW  - viral proteins
KW  - equine infectious anemia virus
KW  - horses
KW  - Lentivirus
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Equus
KW  - Equidae
KW  - Perissodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - DNA sequences
KW  - Equine infectious anaemia virus
KW  - Function
KW  - mRNA
KW  - Rev
KW  - Tat
KW  - viral infections
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and characterization of cDNAs encoding equine infectious anemia virus Tat and putative Rev proteins.
AU  - Stephens, R. M.
AU  - Derse, D.
AU  - Rice, N. R.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1990///
VL  - 64
IS  - 8
SP  - 3716
EP  - 3725
SN  - 0022-538X
AD  - Stephens, R. M.: N.R. Rice, Laboratory of Molecular Virology and Carcinogenesis, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21701, USA.
N1  - Accession Number: 19902209268.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref. Registry Number: 9007-49-2, 63231-63-0.  Subject Subsets: Veterinary Science; Veterinary Science; Agricultural Biotechnology
N2  - Six cDNA clones were isolated and characterized from an equine infectious anaemia virus-infected cell line that displays a Rev-defective phenotype. With the exception of one splice site in one of the clones, all six cDNAs showed the same splicing pattern and consisted of four exons. Exon 1 contained the 5' end of the genome; exon 2 contained the tat gene from mid-genome; exon 3 consisted of a small section of env, near the 5' end of the env gene; and exon 4 contained the putative rev open reading frame from the 3' end of the genome. The structures of the cDNAs predict a bicistronic message in which Tat is encoded by exons 1 and 2 and the presumptive Rev protein is encoded by exons 3 and 4. tat translation appears to be initiated at a non-AUG codon within the first 15 codons of exon 1. Equine infectious anaemia virus-specific tat activity was expressed in transient transfections with cDNA expression plasmids. The predicted wild-type Rev protein contains 30 env-derived amino acids and 135 rev open reading frame residues. All of the cDNAs had a frameshift in exon 4, leading to a truncated protein and thus providing a plausible explanation for the Rev-defective phenotype of the original cells. Peptide antisera were used to detect the faulty protein, thus confirming the cDNA sequence, and to detect the normal protein in productively infected cells.
KW  - Biotechnology
KW  - DNA
KW  - gene expression
KW  - Genes
KW  - horse diseases
KW  - Molecular biology
KW  - nucleotide sequences
KW  - Proteins
KW  - RNA
KW  - viral diseases
KW  - equine infectious anemia virus
KW  - horses
KW  - LENTIVIRUS
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Equus
KW  - Equidae
KW  - Perissodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - Equine infectious anaemia virus
KW  - ribonucleic acid
KW  - viral infections
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent studies of human calcium metabolism using stable isotopic tracers.
AU  - Yergey, A. L.
AU  - Abrams, S. A.
AU  - Vieira, N. E.
AU  - Eastell, R.
AU  - Hillman, L. S.
AU  - Covell, D. G.
JO  - Canadian Journal of Physiology and Pharmacology
JF  - Canadian Journal of Physiology and Pharmacology
Y1  - 1990///
VL  - 68
IS  - 7
SP  - 973
EP  - 976
SN  - 0008-4212
AD  - Yergey, A. L.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911435248.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Number of References: 11 ref. Registry Number: 7440-70-2.  Subject Subsets: Human Nutrition
N2  - Calcium metabolism was studied in premature infants, 2 weeks old, after adding 44Ca to a feed of the milk formula and injecting 46Ca intravenously before feeding. Older children and adults were given 44Ca in a drink with a normal food; 42Ca was used as the intravenous tracer. Thermal ionization mass spectrometry was used to measure calcium isotope ratios with a relative accuracy of about 1% for natural abundance ratios and a precision of about 1% relative to the mean. Changes of natural abundance ratios for calcium in blood, urine, and faeces had a limit of detection of about 2 Δ% excess (observed ratio-natural abundance ratio) natural abundance ratio × 100. The mathematical rationale for clinical studies of fractional absorption of dietary calcium and the kinetics of calcium's internal distribution are presented.
KW  - Calcium
KW  - estimation
KW  - isotopes
KW  - metabolism
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435248&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of dihydrofolate reductase of Pneumocystis carinii and Toxoplasma gondii.
AU  - Kovacs, J. A.
AU  - Allegra, C. J.
AU  - Masur, H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1990///
VL  - 71
IS  - 1
SP  - 60
EP  - 68
SN  - 0014-4894
AD  - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19900865226.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 9002-03-3.  Subject Subsets: Protozoology; Public Health
N2  - The dihydrofolate reductase (DHFR) of P. carinii and T. gondii was characterized to facilitate the identification of more selective DHFR inhibitors as potential antiprotozoal agents. Similar to all reported protozoa, T. gondii has a bifunctional enzyme of 120 000 MW, that possesses both DHFR and thymidylate synthase (TS) activity. Unexpectedly, P. carinii DHFR activity was present on a small molecule of MW 26 000. T. gondii DHFR and TS activity coeluted during affinity chromatography using a methotrexate-Sepharose column, whereas P. carinii DHFR and TS activity were separated by affinity chromatography using the same column. P. carinii DHFR was easily distinguished from rat DHFR, which is similar in size, by the differences in Kmfor dihydrofolate (P. carinii, 17.6 ± 3.9 µM; rat, 4.0 ± 2.2 µM). Since all protozoa reported have a large MW, bifunctional DHFR, these studies support the classification of P. carinii as a fungus.
KW  - biochemistry
KW  - dihydrofolate reductase
KW  - enzymes
KW  - Human diseases
KW  - Opportunistic infections
KW  - parasites
KW  - Taxonomy
KW  - Apicomplexa
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - fungus
KW  - systematics
KW  - tetrahydrofolate dehydrogenase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunological involvement in the efficacy of praziquantel.
AU  - Brindley, P. J.
AU  - Sher, A.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1990///
VL  - 71
IS  - 2
SP  - 245
EP  - 248
SN  - 0014-4894
AD  - Brindley, P. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900866713.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 55268-74-1.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Recent findings concerning the involvement of immune responses in the mode of action of praziquantel (primarily in relation to experimental Schistosoma mansoni infections) are reviewed.
KW  - activity
KW  - Anthelmintics
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - immunology
KW  - mode of action
KW  - parasites
KW  - Praziquantel
KW  - Digenea
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin D status and related parameters in a healthy population: the effects of age, sex, and season.
AU  - Sherman, S. S.
AU  - Hollis, B. W.
AU  - Tobin, J. D.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1990///
VL  - 71
IS  - 2
SP  - 405
EP  - 413
SN  - 0021-972X
AD  - Sherman, S. S.: Gerontology Research Center, National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19911433299.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Registry Number: 1406-16-2.  Subject Subsets: Human Nutrition
N2  - The effects of age, sex, renal function and seasonal variation on serum values within the vitamin D endocrine system were studied cross-sectionally in a healthy population of 167 men and 114 women, 20 to 94 years old. Serum 25-hydroxy-cholecalciferol (250HCC) and 1,25-dihydroxycholecalciferol (1,25DiOHCC) did not decline with age in either sex. Nonlinear regression analyses showed a significant seasonal variation in 25OHCC and 1,25DiOHCC in both sexes. Serum intact parathyrin (PTH) increased significantly by 35% over the age range in both sexes. In women, serum phosphorous and total and ionized calcium concentrations were constant with age. In men, P concentration decreased 25% across the age range and total ionized Ca decreased 4%. Creatinine clearance was reduced with age, but was not related to 1,25DiOHCC in either sex. Only in men was there a significant but modest inverse relation between creatinine clearance and PTH (r = -0.212). It is concluded that in healthy persons compromised vitamin D status or serum 1,25DiOHCC concentrations are not a normal concomitant of aging; declining glomerular filtration is not the principle cause of the age-related rise in PTH; and there are marked sex differences in P metabolism across the age range.
KW  - age
KW  - blood
KW  - seasonal variation
KW  - sex differences
KW  - Vitamin D
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - seasonal changes
KW  - seasonal fluctuations
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433299&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Frequency of variant antigens in Giardia lamblia.
AU  - Nash, T. E.
AU  - Banks, S. M.
AU  - Alling, D. W.
AU  - Merritt, J. W., Jr.
AU  - Conrad, J. T.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1990///
VL  - 71
IS  - 4
SP  - 415
EP  - 421
SN  - 0014-4894
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institutes of Health, Bldg. 4, Rm. 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910868607.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The rate of antigenic variation and the size of the variant antigen repertoire were estimated in clones of G. lamblia which reexpresses surface variant antigens that are characteristics of its parent. Calculations were based on determinations of the number of trophozoites expressing defined or nondefined epitopes as well as the total number of trophozoites in newly established clones. The rate of appearance of variant antigens containing defined epitopes was expressed as the number of generations until the first trophozoite expressing a defined epitope appeared. In clones of isolate WB, tested because their major surface variant antigens were largely nondefined, variants expressing epitopes recognized by Mabs 6E7 or 3F6 appeared after approximately 12 generations. Variants expressing epitopes recognized by MAb 5C1 appeared at about 13 generations, significantly greater than for the other epitopes. The rate of antigenic variation was studied in another isolate, GS/M, whose surface epitope repertoire differs from that of isolate WB. A single epitope recognized by MAb G10/4 was tested. Trophozoites reexpressing this epitope first appeared after about 6.5 generations, significantly less than in WB. Therefore, the single epitope studied in isolate GS/M is reexpressed much more frequently than those of WB. In isolate WB, the epitopes recognized by MAb 6E7 and 3F6 tended to appear at the same time. The median number of variant antigens in WB was estimated to lie between 20.5 and 184.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors have examined the rates of generation of variant surface proteins in Giardia lamblia. They showed that from clonal origins 11 to 13 generations were required to detect the appearance of the antigens by use of a range of monoclonal antibodies to previously defined surface determinants of the parasite. The period to reappearance of an antigen previously detected in one isolate was as short as 6.5 generations. The authors discuss the parallels that exist between the Giardia variant surface proteins and the Trypanosoma variant surface proteins.It is clear that the investigation of this phenomenon in Giardia is in its infancy and it remains to be seen how extensive the range of variant proteins is. The authors raise questions concerning the biological significance of these observations in relation to disease. Do the surface variations allow evasion of host immune responses and hence persistence of the parasite in the host? S.G. Wright
KW  - antigenic variation
KW  - antigens
KW  - Human diseases
KW  - parasites
KW  - Giardia duodenalis
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - Giardia lamblia
KW  - immunogens
KW  - variant antigen types
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food and nutrient intake differences between smokers and non-smokers in the US.
AU  - Subar, A. F.
AU  - Harlan, L. C.
AU  - Mattson, M. E.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990///
VL  - 80
IS  - 11
SP  - 1323
EP  - 1329
SN  - 0090-0036
AD  - Subar, A. F.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Executive Plaza North 313, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911435700.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - Data from the Second National Health and Nutrition Examination Survey were analysed to estimate food and nutrient intake differences between smokers and non-smokers. Smokers in several age-race-sex categories had lower intakes of vitamin C, folate, fibre and vitamin A than non-smokers, and intake decreased as cigarette consumption increased, particularly for vitamin C, fibre and folate. Smokers were less likely to have consumed vegetables, fruits (particularly fruits and vegetables high in vitamins C and A), high fibre grains, low fat milk, and vitamin and mineral supplements than non-smokers. A negative linear trend was found between smoking intensity and intake of several categories of fruits and vegetables. Data suggest that the high cancer risk associated with smoking is compounded by lower intake of nutrients and foods which are thought to be cancer-protective.
KW  - Cows
KW  - diets
KW  - Food intake
KW  - intake
KW  - milk
KW  - skim milk
KW  - tobacco smoking
KW  - USA
KW  - cattle
KW  - Man
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Milk and Dairy Produce (QQ010) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435700&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fruit and vegetables in the American diet: data from the NHANES II survey.
AU  - Patterson, B. H.
AU  - Block, G.
AU  - Rosenberger, W. F.
AU  - Pee, D.
AU  - Kahle, L. L.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990///
VL  - 80
IS  - 12
SP  - 1443
EP  - 1449
SN  - 0090-0036
AD  - Patterson, B. H.: Clinical and Diagnostic Trials Section, Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Rm 344, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911435695.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Human Nutrition; Potatoes
N2  - 24-h dietary recall data from the Second National Health and Nutrition Examination Survey (1976-80) were used to estimate the numbers of servings of fruit and vegetables consumed by black and white adults, to examine the types of servings (e.g. potatoes, garden vegetables, fruit and juice), and to estimate the mean intake of energy, fat, dietary fibre and vitamins A and C by number of servings. An estimated 45% of the population had no servings of fruit or juice and 22% had no servings of a vegetable on the recall day. Only 27% consumed the 3 or more servings of vegetables and 29% had the 2 or more servings of fruit recommended by the US Departments of Agriculture and of Health and Human Services; 9% had both. Consumption was lower among blacks than whites. The choice of vegetables lacked variety. Diets including at least 3 servings of vegetables and 2 servings of fruit contained about 17 g of dietary fibre. Although energy and fat intake increased with increasing servings of fruit and vegetables, the % of energy from fat remained relatively constant. Although these data are 10 years old, more recent surveys have shown similar results. The discrepancy between dietary guidelines and the actual diet suggests a need for extensive public education.
KW  - Diet studies
KW  - fruit
KW  - intake
KW  - Nutrition
KW  - vegetables
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435695&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Herbicides and non-Hodgkin's lymphoma: new evidence from a study of Saskatchewan farmers.
AU  - Blair, A.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1990///
VL  - 82
IS  - 7
SP  - 544
EP  - 545
SN  - 0027-8874
AD  - Blair, A.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Rm. 418, Bethesda, MD 20892, USA.
N1  - Accession Number: 19902303558.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Weeds
N2  - A commentary is presented on the results of a study of nearly 70 000 farmers aged ≥35 years in Saskatchewan which showed that areas sprayed with herbicide and expenditure on fuel in 1970 were independently associated with the incidence of non-Hodgkin's lymphoma. Farmers who spent more on herbicides, or sprayed more herbicide were more likely to contract the disease. These results are discussed in relation to previous case-control studies which mostly found a similar relationship, and with laboratory experimental evidence which failed to show a relationsuip between the use of phenoxyacetic acid herbicides and non-Hodykin's lymphoma.
KW  - Herbicides
KW  - toxicology
KW  - Canada
KW  - Saskatchewan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Canada
KW  - weedicides
KW  - weedkillers
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902303558&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies.
AU  - Howe, G. R.
AU  - Hirohata, T.
AU  - Hislop, T. G.
AU  - Iscovich, J. M.
AU  - Yuan, J. M.
AU  - Katsouyanni, K.
AU  - Lubin, F.
AU  - Marubini, E.
AU  - Modan, B.
AU  - Rohan, T.
AU  - Toniolo, P.
AU  - Shunzhang, Y.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1990///
VL  - 82
IS  - 7
SP  - 561
EP  - 569
SN  - 0027-8874
AD  - Howe, G. R.: Epidemiology Unit, National Cancer Institute of Canada, McMurrich Building, 3rd Fl., 12 Queen's Park Crescent West, University of Toronto, Toronto, Ont. M5S 1A8, Canada.
N1  - Accession Number: 19911453936.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - A combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer is presented in this review. Analysis shows a consistent, significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women. A consistent protective effect for a number of markers of fruit and vegetable intake was demonstrated; vitamin C intake had the most consistent and significant inverse association with breast cancer risk. If these dietary associations represent causality, the attributable risk (i.e., the percentage of breast cancers that might be prevented by dietary modification) in the North American population is estimated to be 24% for postmenopausal women and 16% for premenopausal women.
KW  - Carcinoma
KW  - diets
KW  - mammary glands
KW  - Canada
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453936&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase.
AU  - Allegra, C. J.
AU  - Boarman, D.
AU  - Kovacs, J. A.
AU  - Morrison, P.
AU  - Beaver, J.
AU  - Chabner, B. A.
AU  - Masur, H.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1990///
VL  - 85
IS  - 2
SP  - 371
EP  - 379
SN  - 0021-9738
AD  - Allegra, C. J.: National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900864664.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology
N2  - It was shown that the dihydropteroate synthase in T. gondii is kinetically distinct from the enzyme characterized from other sources and can be highly purified with a high yield using sequential dye-affinity chromatography. Conditions that allow for stabilization of the purified enzyme were identified, and its physical characteristics were elucidated. The MW of the native protein was 125 000 and the protein appeared to contain both dihydropteroate synthase and 6-hydroxymethyl-dihydropterin pyrophosphokinase activities. The sulfonamide class of compounds varied in inhibitory potency by more than 3 orders of magnitude. Sulfathiazole, sulfamethoxazole, and sulfamethazine, with 50% inhibitory concentrations (IC50s) of 1.7, 2.7, and 5.7 µM, respectively, represent the most potent of this class of inhibitors. Several sulfone analogues, including dapsone, were identified as highly potent inhibitors with IC50s &lt;1 µM. The results of these cell-free experiments were corroborated by investigating the metabolic inhibition produced by the various inhibitors in intact organisms. The qualitative and quantitative relationships between the inhibitors were preserved in both the cell-free and intact cell assay systems. It is suggested that the sulfones may be important therapeutic agents for the treatment of toxoplasmosis.
KW  - Antiprotozoal agents
KW  - biochemistry
KW  - enzymes
KW  - Human diseases
KW  - in vitro
KW  - mode of action
KW  - parasites
KW  - Apicomplexa
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - dihydropteroate synthase
KW  - sulfones
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864664&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle.
AU  - Kida, Y.
AU  - Esposito-del Puente, A.
AU  - Bogardus, C.
AU  - Mott, D. M.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1990///
VL  - 85
IS  - 2
SP  - 476
EP  - 481
SN  - 0021-9738
AD  - Kida, Y.: D.M. Mott, Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 N. 16th Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19901451303.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Insulin-stimulated glycogen synthase activity in human skeletal muscle as correlated with insulin-mediated glucose disposal rate (M) and is reduced in insulin-resistant subjects. Reduced insulin-stimulated glycogen synthase activity associated with reduced fasting glycogen synthase phosphatase activity has previously been reported in skeletal muscle of insulin-resistant Pima Indians. The time course for insulin stimulation of glycogen synthase and synthase phosphatase during a 2-h high-dose insulin infusion (600 mU/min m²) was studied in 6 insulin-sensitive white persons (group IS) and in 5 insulin-resistant Pima Indians (group IR). Percutaneous muscle biopsies were obtained from the quadriceps femoris muscle after insulin infusion for 0, 10, 20, 40 and 120 min. In group IS, insulin-stimulated glycogen synthase activity increased with time and was significantly higher than in group IR. In groups IS, synthase phosphatase activity increased significantly by 25% at 10 min and then decreased gradually. No significant change in synthase phosphatase occurred in group IR and activity was lower than in group IS at 0 to 20 min. These results suggest that a low basal synthase phosphatase activity and a defect in its response to insulin explain, at least in part, reduced insulin stimulation of skeletal muscle glycogen synthase associated with insulin resistance.
KW  - enzyme activity
KW  - insulin
KW  - Skeletal muscle
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451303&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Population-based study of the developmental outcome of children exposed to chloride-deficient infant formula.
AU  - Willoughby, A.
AU  - Graubard, B. I.
AU  - Hocker, A.
AU  - Storr, C.
AU  - Vietze, P.
AU  - Thackaberry, J. M.
AU  - Gerry, M. A.
AU  - McCarthy, M.
AU  - Gist, N. F.
AU  - Magenheim, M.
AU  - Berendes, H.
AU  - Rhoads, G. G.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1990///
VL  - 85
IS  - 4
SP  - 485
EP  - 490
SN  - 0031-4005
AD  - Willoughby, A.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Executive Plaza North Building, Room 630-P, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911429456.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 16887-00-6.  Subject Subsets: Human Nutrition; Soyabeans
N2  - In 1978 and 1979 a large number of children in the USA were given chloride-deficient soya-based infant formula. A representative sample of such children was identified in a southern county by sending a questionnaire by post to the homes of 3639 first- and second-grade children in the public schools. Of the 2329 who responded, 56 reported use of deficient formula and were invited to have developmental testing by 1 of 4 study psychologists at their school. Of the 310 users of other soya formulas, 112 were selected for testing as matched controls on the basis of sex, feeding history, age, birth weight and socio-economic status. After exclusions and refusals, 42 children who used deficient formula and 66 control children were tested using the McCarthy Scales of Children's Abilities. Examiners were unaware of the child's history of formula use. The mean General Cognitive Index was 102.8 in those using deficient formula and 105.4 in controls. After adjustment for demographic differences the children who used chloride-deficient formula had on average 4.9 points less than the controls. The largest difference was in the Quantitative subscale. The results show a significant although small effect of chloride-deficient formula on the long-term developmental outcome of exposed children; however, further study of the results is needed for full confirmation.
KW  - children
KW  - chloride
KW  - deficiency
KW  - infant formulae
KW  - infants
KW  - mental ability
KW  - School children
KW  - soyabean products
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - infant formula
KW  - infant formulas
KW  - intelligence
KW  - school kids
KW  - schoolchildren
KW  - soybean products
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine regulation of antigen-driven immunoglobulin production in filarial parasite infections in humans.
AU  - King, C. L.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1990///
VL  - 85
IS  - 6
SP  - 1810
EP  - 1815
SN  - 0021-9738
AD  - King, C. L.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874378.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 37341-29-0, 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology
N2  - To define the immunoregulatory mechanisms underlying serum IgE levels found in patients with filariasis, polyclonal IgE production by peripheral blood mononuclear cells (PBMC) from 15 patients with either Loa loa or Onchocerca volvulus infections was studied, with a focus on the role of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) in the generation and regulation of the response. Spontaneous in vitro IgE production was elevated in 10 of the 15 patients (836-6464 pg/ml; normals &lt;500 pg/ml). Addition of filarial parasite antigen to PBMC cultures significantly stimulated polyclonal IgE production in an antigen dose-dependent manner in 10 of 12 patients tested. The essential role of IL-4 in the generation of this response was demonstrated when simultaneous addition of anti-IL-4 completely inhibited antigen-stimulated IgE production in all 10 patients studied. An inhibitory role of endogenously produced IFN-γ was also indicated when the addition of anti-IFN-γ to the cultures significantly augmented filarial antigen-stimulated IgE production in these same patients. Addition of 10-1000 U/ml of recombinant human IFN-γ to PBMC completely inhibited parasite antigen-induced IgE production. This study is considered to demonstrate that filarial antigen-stimulated IgE production in patients with filariasis is mediated by IL-4 and down regulated by IFN-γ and suggest that the amount of IgE produced depends on the relative quantity of IL-4 and IFN-γ generated by parasite-specific T cells.
KW  - antibodies
KW  - Cytokines
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - IgE
KW  - immune response
KW  - interferon
KW  - interleukin 4
KW  - parasites
KW  - Loa loa
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - African eyeworm
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum.
AU  - Dolan, S. A.
AU  - Miller, L. H.
AU  - Wellems, T. E.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1990///
VL  - 86
IS  - 2
SP  - 618
EP  - 624
SN  - 0021-9738
AD  - Dolan, S. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910871461.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9001-67-6.  Subject Subsets: Protozoology
N2  - P. falciparum demonstrates variability in its dependence upon erythrocyte sialic acid residues for invasion. Some lines of P. falciparum invade neuraminidase-treated or glycophorin-deficient erythrocytes poorly, or not at all, while other lines invade such cells at substantial rates. To explore the molecular basis of non-sialic acid dependent invasion, parasite lines were selected from a clone (Dd2) that initially exhibited low invasion of neuraminidase-treated erythrocytes. After maintaining Dd2 for several cycles in neuraminidase-treated erythrocytes, parasite lines were recovered that invaded both untreated and neuraminidase-treated erythrocytes at equivalently high rates (Dd2/NM). The change in phenotype was maintained after removal of selection pressure. Four subclones of Dd2 were isolated and each readily converted from sialic acid dependence to non-sialic acid dependence during continuous propagation in neuraminidase-treated erythrocytes. The neuraminidase-selected lines and the Dd2 clone demonstrated identical restriction fragment length polymorphism markers indicating that the Dd2 clone was not contaminated during the selection process. Parasite proteins that bound to neuraminidase-treated and untreated erythrocytes were indistinguishable among the parent Dd2 clone and the neuraminidase-selected lines. The ability of the Dd2 parasite to change its invasion requirements for erythrocyte sialic acid suggests a switch mechanism permitting invasion by alternative pathways.
KW  - cell invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - Human diseases
KW  - parasites
KW  - SIALIDASE
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - blood red cells
KW  - exo-alpha-sialidase
KW  - neuraminidase
KW  - parasite host relationships
KW  - red blood cells
KW  - sialic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871461&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Exposure to a chloride-deficient formula during infancy: outcome at ages 9 and 10 years.
AU  - Malloy, M. H.
AU  - Willoughby, A.
AU  - Graubard, B.
AU  - Lynch, J.
AU  - McCarthy, M.
AU  - Moss, H.
AU  - Vietze, P.
AU  - Rhoads, G. G.
AU  - Berendes, H.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1990///
VL  - 86
IS  - 4
SP  - 601
EP  - 610
SN  - 0031-4005
AD  - Malloy, M. H.: Epidemiology Branch/PRP, National Institute of Child Health and Human Development, Executive Plaza North, Room 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911435164.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Human Nutrition; Soyabeans
N2  - A school-based mail survey of the 1978 to 1979 birth cohort of two metropolitan Washington, DC, counties was conducted to find children exposed to the chloride-deficient formulas Neo-Mull-Soy and Cho-Free during infancy. Children who had ingested other soya formulas with an adequate chloride content were also found and matched to the exposed children by sex, race, birth weight, age, mixed feeding status and maternal education. A total of 117 of the exposed children and 261 soya control children were given a battery of psychologic tests in their homes to determine whether intellectual development was affected as a result of exposure to the chloride-deficient formulas. Results showed that there were no differences in scores between groups on the Wechsler Intelligence Scale for Children-Revised, the Boston Naming Test, the Rey-Osterrieth Test, or the FAS Verbal Fluency Test. There was no correlation between duration of exclusive exposure to the chloride-deficient formulas and the Wechsler Intelligence Scale for Children-Revised Full-Scale IQ Score (Pearson product-moment r = -0.0825, P=0.28). It is advised that these results cannot be extrapolated to exposed children with documented hypochloraemic metabolic alkalosis. It is concluded that in children without documented evidence of hypochloraemic metabolic alkalosis, exposure to the chloride-deficient formulas Neo-Mull-Soy or Cho-Free during infancy did not result in any long-term adverse effects on cognitive development.
KW  - chlorides
KW  - development
KW  - infant formulae
KW  - Infants
KW  - soyabean products
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - infant formula
KW  - infant formulas
KW  - soybean products
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435164&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Skeletal muscle metabolism is a major determinant of resting energy expenditure.
AU  - Zurlo, F.
AU  - Larson, K.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1990///
VL  - 86
IS  - 5
SP  - 1423
EP  - 1427
SN  - 0021-9738
AD  - Zurlo, F.: E. Ravussin, National Institutes of Health, 4212 N. 16th Street, Rm. 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19911431092.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Energy expenditure varies among subjects, independent of body size and composition, and persons with a "low" metabolic rate seem to be at higher risk of gaining weight. To assess the importance of skeletal muscle metabolism as a determinant of metabolic rate, 24-h energy expenditure, basal metabolic rate (BMR) and sleeping metabolic rate (SMR) were estimated by indirect calorimetry in 14 subjects (7 men, 7 women; 30±6 years old (mean±s.d.); 79.1±17.3 kg; 22±7% body fat), and compared to forearm oxygen uptake. Values of energy expenditure were adjusted for individual differences in fat-free mass, fat mass, age and sex. Adjusted BMR and SMR, expressed as deviations from predicted values, were correlated with forearm resting oxygen uptake (ml O2/litre forearm) (r = 0.72, P&lt;0.005 and r = 0.53, P=0.05, respectively). These findings suggest that differences in resting muscle metabolism account for part of the variance in metabolic rate among individual persons and may play a role in the pathogenesis of obesity.
KW  - metabolism
KW  - Resting energy exchange
KW  - skeletal muscle
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911431092&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.
AU  - Sher, A.
AU  - Coffman, R. L.
AU  - Hieny, S.
AU  - Scott, P.
AU  - Cheever, A. W.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1990///
VL  - 87
IS  - 1
SP  - 61
EP  - 65
SN  - 0027-8424
AD  - Sher, A.: Immunology and Cell Biology and Host-Parasite Relations Sections, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874080.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - To investigate the immunological basis of the eosinophil response in schistosomiasis and directly assess the function of eosinophils in egg-induced pathology, mice infected with S. mansoni were injected with a MAb produced against interleukin 5 (IL-5), a cytokine previously shown to stimulate eosinophil differentiation in vitro. This treatment suppressed the generation of eosinophil myelocyte precursors in the bone marrow and reduced to background levels the numbers of mature eosinophils in the marrow, in circulation, and within acute schistosome egg granulomata. Nevertheless, granulomata in the anti-IL-5-treated/eosinophil-depleted mice at 8 weeks of infection were only marginally smaller than those in animals injected with control MAb, and hepatic fibrosis was comparable in the 2 groups. Additional parameters such as worm burden, egg output, and serum IgE levels were unaltered by the anti-IL-5 treatment. In contrast, infected animals injected with MAb against γ interferon (IFN-γ) displayed circulating eosinophil levels that were elevated with respect to control mice, possibly because of an enhanced release of mature eosinophils from the marrow, and developed egg granulomata that were indistinguishable in size and cellular composition from those in control animals. Immunological assays revealed that lymphocytes from acutely infected mice produce large quantities of IL-5 but minimal IFN-γ when stimulated with either egg antigen or mitogen. Taken together, these results indicate that neither IL-5 nor eosinophils are essential for egg-induced pathology but suggest that lymphocytes that belong to the IL-5-producing TH2 subset predominate during acute infection and may induce granuloma formation by the production of other cytokines.
KW  - Cytokines
KW  - eosinophilia
KW  - eosinophils
KW  - helminths
KW  - immune response
KW  - immunopathology
KW  - interleukin 5
KW  - Laboratory animals
KW  - parasites
KW  - schistosomiasis
KW  - treatment
KW  - Digenea
KW  - mice
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - eosinophil leukocytes
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - monoclonal antibody against interleukin 5
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
AU  - Peterson, D. S.
AU  - Milhous, W. K.
AU  - Wellems, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1990///
VL  - 87
IS  - 8
SP  - 3018
EP  - 3022
SN  - 0027-8424
AD  - Peterson, D. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874737.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 516-21-2, 9002-03-3, 500-92-5.  Subject Subsets: Protozoology
N2  - Analysis of the P. falciparum dihydrofolate reductase (DHFR) from different parasites showed the structural basis for differential susceptibility to the antifolate drugs proguanil and pyrimethamine. Parasites harbouring a pair of point mutations from Ala-16 to Val016 and from Ser-108 to Thr-108 are resistant to cycloguanil (the active metabolite of proguanil) but not to pyrimethamine. A single Asn-108 mutation, on the other hand, confers resistance to pyrimethamine with only a moderate decrease in susceptibility to cycloguanil. Significant cross-resistance to both drugs occurs in parasites having mutations that include Ser-108-&gt;Asn-108 and Ile-164-&gt;Leu-164. These results reflect the distinct structures of pyrimethamine and cycloguanil and suggest fine differences in binding within the active site cavity of DHFR. Alternative inhibitors, used alone or in combination, may be effective against some strains of cycloguanil- or pyrimethamine-resistant malaria.
KW  - Antimalarials
KW  - Antiprotozoal agents
KW  - cycloguanil
KW  - dihydrofolate reductase
KW  - drug resistance
KW  - molecular genetics
KW  - parasites
KW  - proguanil
KW  - resistance mechanisms
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - chlorguanide
KW  - chloroguanide
KW  - cycloguanil embonate
KW  - tetrahydrofolate dehydrogenase
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16.
AU  - Pash, J.
AU  - Popescu, N.
AU  - Matocha, M.
AU  - Rapoport, S.
AU  - Bustin, M.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1990///
VL  - 87
IS  - 10
SP  - 3836
EP  - 3840
SN  - 0027-8424
AD  - Pash, J.: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900180535.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2  - The gene for human high-mobility-group (HMG) chromosomal protein HMG-14 is located on human chromosome 21q22.3, a region associated with the pathogenesis of Down's syndrome. The expression of this gene was examined in mouse embryos which were trisomic in chromosome 16, and considered to be an animal model for Down's syndrome. RNA blot-hybridization analysis and analysis of HMG-14 protein levels indicated that mouse trisomy 16 embryos contained approx. 1.5 times more HMG-14 mRNA and protein than their normal littermates, suggesting a gene dosage effect. It is suggested that the HMG-14 gene may represent an additional marker for Down's syndrome.
KW  - animal models
KW  - Biotechnology
KW  - Chromosomes
KW  - Down's syndrome
KW  - gene expression
KW  - gene mapping
KW  - Heteroploidy
KW  - proteins
KW  - trisomy
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mongolism
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
AU  - Aoyama, T.
AU  - Yamano, S.
AU  - Guzelian, P. S.
AU  - Gelboin, H. V.
AU  - Gonzalez, F. J.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1990///
VL  - 87
IS  - 12
SP  - 4790
EP  - 4793
SN  - 0027-8424
AD  - Aoyama, T.: Laboratory of Molecular Carcinogenesis, National Cancer Insitute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901206664.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9035-51-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - Twelve forms of human hepatic cytochrome P450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P450s were analysed for their abilities to activate aflatoxin B1 to metabolites having mutagenic or DNA-binding properties. Five forms, P450s IA2, IIA3, IIB7, IIIA3 and IIIA4, activated aflatoxin B1 to mutagenic metabolites as assessed by the production of His revertants of Salmonella typhimurium in the Ames test. The same P450s catalyzed conversion of aflatoxin B1 to DNA-bound derivatives as judged by an in situ assay in which the radiolabelled carcinogen was incubated with cells expressing the individual P450 forms. Seven other human P450s, IIC8, IIC9, IID6, IIE1, IIF1, IIIA5 and IVB1, did not significantly activate aflatoxin B1 as measured by both the Ames test and the DNA-binding assay. Moreover, polyclonal anti-rat liver P450 antibodies that cross-react with individual human P450s IA2, IIA3, IIIA3 and IIIA4 each inhibited aflatoxin B1 activation catalyzed by human liver S-9 extracts. Inhibition ranged from as low as 10% with antibody against IIA3 to as high as 65% with antibody against IIIA3 and IIIA4. It is concluded that metabolic activation of aflatoxin B1 in human liver involves the contribution of multiple forms of P450.
KW  - Aflatoxins
KW  - cytochrome P-450
KW  - Mycotoxins
KW  - activation
KW  - fungal toxins
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Environmental lead toxicity: nutrition as a component of intervention.
AU  - Mahaffey, K. R.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1990///
VL  - 89
SP  - 75
EP  - 78
SN  - 0091-6765
AD  - Mahaffey, K. R.: National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19931457428.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 7439-92-1.  Subject Subsets: Human Nutrition
N2  - The influence of nutritional status on susceptibility to the toxicity of lead is discussed. Emphasis is given to dietary factors of substantial clinical importance. Subtle changes in susceptibility are difficult to evaluate in conditions of overwhelming Pb exposure. It is clear that subtle effects of Pb-exposure on neurobehavioural and cognitive development are a major concern. The role of nutrition is considered to be an adjunct to reduction of environmental Pb exposure, which is the primary means of reducing adverse health effects of Pb. Nutrition should be evaluated as a component of strategies to address this issue.
KW  - Lead
KW  - Nutrition
KW  - Toxicity
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The apparent validity of diet questionnaires is influenced by number of diet-record days used for comparison.
AU  - Potosky, A. L.
AU  - Block, G.
AU  - Hartman, A. M.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1990///
VL  - 90
IS  - 6
SP  - 810
EP  - 813
SN  - 0002-8223
AD  - Potosky, A. L.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911436524.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - The effect of the number of diet records used as reference data on the apparent validity of a diet history questionnaire was examined using data from 97 subjects in the Women's Health Trial feasibility study. Pearson correlation coefficients were computed between the estimates of usual individual intake from the questionnaire and estimates from the mean of three 4-day records obtained over a 1-year period, the mean of the 2 most recent records, and the record obtained a year after the start of the study. Results show that the apparent validity of a questionnaire increases when it is compared with a greater number of 4-day food records. More diet-record days should therefore be included when validating other dietary assessment instruments.
KW  - Diet study techniques
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antigenic analysis of Cysticercus cellulosae by crossed immunoelectrophoresis and its role in immune diagnosis of neurocysticercosis.
AU  - Katti, M. K.
AU  - Jagannath, C.
AU  - Gokul, B. N.
AU  - Chandramuki, A.
AU  - Sehgal, S.
JO  - Indian Journal of Medical Research
JF  - Indian Journal of Medical Research
Y1  - 1990///
VL  - 91
SP  - 39
EP  - 43
AD  - Katti, M. K.: A. Chandramuki, Department of Medical Microbiology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
N1  - Accession Number: 19900864417.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Helminthology
N2  - The antigenic composition of Cysticercus cellulosae cysts excised from infected pig and autopsied human brain was analysed by crossed immunoelectrophoresis with an intermediate gel technique using rabbit hyperimmune serum. Normal pork muscle and human brain antigen were used to differentiate parasite-derived components from those of the host. Attempts were made to look for immunodominant antigens by analysing preparations of different parts of cyst (scolex and fluid) using rabbit hyperimmune serum. Twenty three antigenic components were identified in sonicated extract of porcine cyst, of which 15 were parasite-derived. Scolex extract showed 10, cyst fluid 9 and human cyst sonicate 11 parasite-derived antigens. Serum and cerebrospinal fluid of 4 patients with neurocysticercosis reacted with 12 parasite-derived antigens of porcine cyst sonicate (PCS). It is noted that human cyst sonicate lacked 4 of the parasite-derived antigens present in the PCS.
KW  - antigens
KW  - characterization
KW  - counterimmunoelectrophoresis
KW  - helminths
KW  - Human diseases
KW  - immunodiagnosis
KW  - metacestodes
KW  - parasites
KW  - Cestoda
KW  - Taenia solium
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - antigenicity
KW  - immunogens
KW  - parasitic worms
KW  - pork tapeworm
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduced mannose incorporation into GDP-mannose and dolichol-linked intermediates of N-glycosylation in hamster liver during vitamin A deficiency.
AU  - Rimoldi, D.
AU  - Creek, K. E.
AU  - Luca, L. M. de
JO  - Molecular and Cellular Biochemistry
JF  - Molecular and Cellular Biochemistry
Y1  - 1990///
VL  - 93
IS  - 2
SP  - 129
EP  - 140
SN  - 0300-8177
AD  - Rimoldi, D.: Differentiation Control Section, Laboratory of Cellular Carcinogeneis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911436546.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 3458-28-4.  Subject Subsets: Human Nutrition
N2  - The in vivo incorporation of [2-³H]mannose into GDP-mannose, dolichyl phosphate mannose (Dol-P-Man), lipid-linked oligosaccharides, and glycopeptides of hamster liver was investigated during the progression of vitamin A deficiency. Hamsters maintained on a vitamin A-free diet showed reduced incorporation of mannose into GDP-mannose about 10 days before onset of clinical signs of vitamin A deficiency. The decrease in [2-³H]mannose incorporated into GDP-mannose was accompanied by reduced incorporation of label into Dol-P-Man, lipid linked oligosaccharides and glycopeptides, which became more severe with the progression of vitamin A deficiency. By the time they reached a plateau stage of growth, hamster fed vitamin A-free diet showed a 50% reduction in the amount of [2-³H]mannose converted to GDP-mannose, and the radioactivity associated with Dol-P-Man and glycopeptides was reduced by about 60% compared with retinoic acid-supplemented controls. It is concluded that the reduced incorporation of mannose into lipidic intermediates and glycoproteins observed during vitamin A deficiency is due to impaired GDP-mannose synthesis.
KW  - liver
KW  - Mannose
KW  - metabolism
KW  - vitamin A deficiency
KW  - hamsters
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hypovitaminosis A
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasive infection with Sarcinosporon inkin in a patient with chronic granulomatous disease.
AU  - Kenney, R. T.
AU  - Kwon-Chung, K. J.
AU  - Witebsky, F. G.
AU  - Melnick, D. A.
AU  - Malech, H. L.
AU  - Gallin, J. I.
JO  - American Journal of Clinical Pathology
JF  - American Journal of Clinical Pathology
Y1  - 1990///
VL  - 94
IS  - 3
SP  - 344
EP  - 350
SN  - 0002-9173
AD  - Kenney, R. T.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19901207705.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in which S. inkin caused progressive pneumonia in an 18-yr-old man with chronic granulomatous disease. Histological sections of right upper lobe lung tissue showed clusters of globose to oblong hyaline-walled, septate, sporangia throughout the necrotic areas within the pyogranulomas. Pure cultures of S. inkin were recovered from the surgical specimen of the lung. Current status of the taxonomy of S. inkin is reviewed and clarified. Treatment of the patient with amphotericin B (total dose 2 g) and white blood cell transfusions led to clinical and radiographical response.
KW  - hosts
KW  - infections
KW  - lungs
KW  - predisposition
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Ascomycota
KW  - fungi
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chronic granulomatous disease
KW  - fungus
KW  - Hyphomycetes
KW  - mitosporic fungi
KW  - Sarcinosporon
KW  - Sarcinosporon inkin
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Do we have a nutritional treatment for age-related cataract or macular degeneration?
AU  - Sperduto, R. D.
AU  - Ferris, F. L., III
AU  - Kurinij, N.
JO  - Archives of Ophthalmology
JF  - Archives of Ophthalmology
Y1  - 1990///
VL  - 108
IS  - 10
SP  - 1403
EP  - 1405
SN  - 0003-9950
AD  - Sperduto, R. D.: Biometry and Epidemiology Program, National Eye Institute, National Institutes of Health, Bldg 31, Room 6A24, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911438644.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Human Nutrition
N2  - Animal research and preliminary epidemiological studies have suggested a protective role for vitamins and certain trace minerals with antioxidant capabilities in development of cataract and macular degeneration. This editorial reviews the data and suggests that currently, there is no convincing evidence that nutritional supplementation can affect development or progression of age-related cataracts or age-related macular degeneration. Perception that toxicity from vitamin/mineral supplementation is low and recommended use of supplements for patients with these conditions is queried. Most such supplements are used to treat conditions and complaints for which their efficacy has not been demonstrated. Furthermore, a clear definition of toxicity has not been established for many nutrients, and use of megadoses of these supplements is increasing. There is growing concern that excessive intake of fat-soluble vitamins, some trace minerals and even some water-soluble vitamins, may be associated with toxicity, including undesirable interactions with other drugs and other vitamins. The National Eye Institute's multiyear study of the clinical course and prognosis of age-related macular degeneration and age-related cataract will include a randomized trial component to evaluate effect of vitamin/mineral supplements on development.
KW  - diet treatment
KW  - eye diseases
KW  - Old age
KW  - reviews
KW  - diet prescription
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of Toxoplasma gondii in paraffin-embedded sections by the polymerase chain reaction.
AU  - Brézin, A. P.
AU  - Egwuagu, C. E.
AU  - Burnier, M., Jr.
AU  - Silveira, C.
AU  - Mahdi, R. M.
AU  - Gazzinelli, R. T.
AU  - Belfort, R., Jr.
AU  - Nussenblatt, R. B.
JO  - American Journal of Ophthalmology
JF  - American Journal of Ophthalmology
Y1  - 1990///
VL  - 110
IS  - 6
SP  - 599
EP  - 604
SN  - 0002-9394
AD  - Brézin, A. P.: C. E. Egwuagu, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg.10, Rm.10N202, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910881494.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology
N2  - The polymerase chain reaction was used to amplify DNA fragments specific to T. gondii (RH strain). The sensitivity of the technique allowed for the detection of as few as 10 cultured T. gondii tachyzoites. The same amplification technique was applied to deparaffinized ocular sections from 2 cases of ocular toxoplasmosis, a 50-year-old man and a 30-year-old man, both from Brazil. Although toxoplasmic cysts could only be seen in one eye by optical microscopy, polymerase chain reaction allowed the identification of the parasite in both cases. This study indicates the feasibility of a sensitive DNA-based assay to complement pathological studies of an ocular parasitic disease.
KW  - case reports
KW  - diagnosis
KW  - eyes
KW  - human diseases
KW  - parasites
KW  - polymerase chain reaction
KW  - Toxoplasmosis
KW  - Brazil
KW  - South America
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Localization of myosin IC and myosin II in Acanthamoeba castellanii by indirect immunofluorescence and immunogold electron microscopy.
AU  - Baines, I. C.
AU  - Korn, E. D.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1990///
VL  - 111
IS  - 5, I
SP  - 1895
EP  - 1904
SN  - 0021-9525
AD  - Baines, I. C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900869162.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology
N2  - Polyclonal antisera were raised against purified Acanthamoeba myosin II and to a synthetic 26 amino acid peptide that corresponds in sequence to the phosphorylation site of Acanthamoeba myosin IC. These antisera are specific for their respective antigens as determined by immunoblotting after SDS-PAGE of total cell lysates. By using the antisera, localization studies were performed by indirect immunofluorescence and by immunogold electron microscopy. Myosin II occurred in the cell cytoplasm and appeared to be concentrated in the cortex. Immunogold cytochemistry revealed at high resolution that myosin II is organized into rodlike filaments ~200 nm long. The antibody raised against the myosin IC synthetic peptide recognized both the plasma membrane and the membrane of the contractile vacuole. The plasma membrane of the contractile vacuole. The plasma membrane staining was labile to treatment with saponin suggesting an intimate association of the myosin IC with membrane phospholipids. Immunogold cytochemistry with the antimyosin IC synthetic peptide showed that the myosin IC is closely associated with the membrane bilayer.
KW  - Biochemistry
KW  - myosins
KW  - parasites
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Rheumatoid arthritis, methotrexate therapy and Pneumocystis pneumonia.
AU  - Leff, R. L.
AU  - Case, J. P.
AU  - McKenzie, R.
T2  - Annals of Internal Medicine
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1990///
VL  - 112
IS  - 9
SP  - 716
EP  - 716
SN  - 0003-4819
AD  - Leff, R. L.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900865842.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Registry Number: 59-05-2.  Subject Subsets: Protozoology
N2  - A case of P. carinii pneumonia in a 66-year-old man with rheumatoid arthritis who was treated with low-dose methotrexate without corticosteroids, is reported from Bethesda, USA. Methotrexate therapy had been started 6 months earlier, up to 22.5 mg/week, with marked improvement in the rheumatoid arthritis. A preliminary diagnosis of methotrexate-induced pneumonitis was made when the patient presented with progressive cough, fever and shortness of breath, but bronchoscopy washes revealed clusters of P. carinii cysts. Therapy with high-dose trimethoprim and sulfamethoxazole, followed by pentamidine for a total of 2 weeks resulted in rapid clinical improvement.
KW  - case reports
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - immunosuppression
KW  - Methotrexate
KW  - Opportunistic infections
KW  - parasites
KW  - Rheumatoid arthritis
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - amethopterin
KW  - fungus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Are corticosteroids beneficial as adjunctive therapy for Pneumocystis pneumonia in AIDS?
AU  - Kovacs, J. A.
AU  - Masur, H.
T2  - Annals of Internal Medicine
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1990///
VL  - 113
IS  - 1
SP  - 1
EP  - 3
SN  - 0003-4819
AD  - Kovacs, J. A.: The National Institutes of Health, Bethesda MD 20892, USA.
N1  - Accession Number: 19900865719.  Publication Type: Editorial.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology
N2  - The treatment of P. carinii pneumonia in patients with AIDS, is discussed, with particular reference to recent studies on the use of corticosteroids as adjuvants to specific anti-Pneumocystis therapy.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - corticoids
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - treatment
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - corticosteroids
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Respiratory cryptosporidiosis in a patient with malignant lymphoma: report of a case and review of the literature.
AU  - Travis, W. D.
AU  - Schmidt, K.
AU  - MacLowry, J. D.
AU  - Masur, H.
AU  - Condron, K. S.
AU  - Fojo, A. T.
JO  - Archives of Pathology and Laboratory Medicine
JF  - Archives of Pathology and Laboratory Medicine
Y1  - 1990///
VL  - 114
IS  - 5
SP  - 519
EP  - 522
SN  - 0003-9985
AD  - Travis, W. D.: Laboratory of Pathology, Bldg 10, Room 2 N212, National Cancer Institute, National Institutes of Health, Bethesda MD 20892, USA.
N1  - Accession Number: 19900865713.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology
N2  - The first case of respiratory cryptosporidiosis recognized at the National Institutes of Health, USA, is reported. An antemortem diagnosis was made based on recognition of acid-fast cryptosporidia in an induced sputum specimen obtained from a 64-year-old woman with malignant lymphoma and an associated profound immunodeficiency. Autopsy confirmed the presence of Cryptosporidium along the apical aspect of the respiratory epithelium lining the trachea, bronchi, and bronchioles. Cryptosporidia were also identified in the duodenum and gallbladder. Immunohistochemical staining of the paraffin-embedded autopsy lung sections using a monoclonal antibody verified the diagnosis of cryptosporidiosis. Review of this case and the literature suggests that respiratory cryptosporidiosis is characterized by a chronic tracheitis, bronchitis, and bronchiolitis but generally does not cause severe pulmonary dysfunction.
KW  - case reports
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - lungs
KW  - neoplasms
KW  - Opportunistic infections
KW  - parasites
KW  - North America
KW  - USA
KW  - Apicomplexa
KW  - Cryptosporidium
KW  - man
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Cryptosporidiidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of the progression of vitamin A deficiency on glucose, galactose and mannose incorporation into sugar phosphates and sugar nucleotides in hamster liver.
AU  - Shankar, S.
AU  - Creek, K. E.
AU  - Luca, L. M. de
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1990///
VL  - 120
IS  - 4
SP  - 361
EP  - 374
SN  - 0022-3166
AD  - Shankar, S.: L.M. de Luca, Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37, Room 3A-17, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901450675.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - The incorporation of [2-³H]mannose into dolichyl phosphate mannose and glycoproteins is remarkably reduced in livers of vitamin A-deficient hamsters. To determine whether vitamin A deficiency selectively alters the level of mannose incorporation into sugar phosphates and sugar nucleotides, incorporation of [2-³H]mannose, [5-³H]mannose, [5-³H]glucose and [4,5-³H]galactose into sugar phosphates and sugar nucleotides was studied in vivo. Male hamsters fed on a vitamin A-depleted or a retinoic acid-supplemented (3 μg/g) diet were used at 4, 6 and 8 weeks old; the hamsters were killed at various times after an intraperitoneal injection of the radiolabelled sugar. There was a two- to threefold increase in the amount of [2-³H]mannose in liver of hamsters fed on a vitamin A-depleted diet for 4 weeks, resulting in enhanced incorporation into mannosyl-phosphate and guanosine diphosphate (GDP) mannose. As deficiency progressed, there was a smaller increase in [2-³H]mannose and a significant decrease in [³H]mannose-phosphate and GDP-[³H]mannose, suggesting a decreased mannose kinase activity. [5-³H]Glucose-labelled livers showed a difference in the total uptake of the label or its incorporation into uridine diphosphate glucose and galactose-phosphate during the 8-week study. However, the synthesis of glucosyl-phosphate was reduced by 50 to 90% at 6 and 8 weeks of deficiency, suggesting an impaired glucokinase activity. In hamsters injected with [4,5-³H]galactose only [³H]glucose was found within 5 min in the free-sugar fraction. In contrast, as much as 70% of the label in the sugar phosphate and sugar nucleotide fraction remained as [³H]galactose even at 60 min. These effects on sugar, sugar phosphate and sugar nucleotide formation in part may explain the effects of vitamin A deficiency on glycoconjugate biosynthesis.
KW  - Vitamin A deficiency
KW  - hamsters
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hypovitaminosis A
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Unequal distribution of a stable isotopic calcium tracer between casein and whey fractions of infant formulas, human milk and cow's milk.
AU  - Abrams, S. A.
AU  - Vieira, N. E.
AU  - Yergey, A. L.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1990///
VL  - 120
IS  - 12
SP  - 1672
EP  - 1676
SN  - 0022-3166
AD  - Abrams, S. A.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910445859.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 7440-70-2, 9000-71-9.  Subject Subsets: Dairy Science; Human Nutrition
N2  - Measurement of calcium absorption with tracers assumes a complete equilibration of tracer with milk calcium. In this study, the equilibration of tracer between the micellar casein and soluble fractions (primarily whey) of 2 types of infant formulae (standard cow milk-based and formula for premature infants), human milk and cow milk was measured in vitro, using milk samples enriched with 42Ca and analysed by thermal ionization MS. Incomplete equilibration of tracer occurred with the micellar casein fraction of all milks. The least equilibration with micellar casein was found with premature infant formula, for which the ratio of slopes of the equilibration lines (whey:casein) was 8.5:1. These differences may be due to Ca-casein binding in cow milk-based formulae. The effects of the lack of tracer equilibration in vivo could not be determined. However, unequal bioavailability of casein- vs. whey-bound Ca may exist.
KW  - Calcium
KW  - casein
KW  - Cows
KW  - distribution
KW  - human milk
KW  - infant formulae
KW  - isotopes
KW  - milk
KW  - tracers
KW  - whey
KW  - cattle
KW  - Man
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - breast milk
KW  - infant formula
KW  - infant formulas
KW  - Milk and Dairy Produce (QQ010) 
KW  - Human Nutrition (General) (VV100) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Food Composition and Quality (QQ500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dose-response tests in field surveys.
AU  - Underwood, B. A.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1990///
VL  - 120
IS  - 11 suppl.
SP  - 1455
EP  - 1458
SN  - 0022-3166
AD  - Underwood, B. A.: National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911429615.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 13 ref. Subject Subsets: Human Nutrition
N2  - Dose response tests for some nutrients can provide information on the tissue status of a nutrient that may not be reflected by single measures of the concentration in body fluids. Where clear cut-off points for relative nutritional states are not well defined, dose response tests can provide a base for interpretation of values that fall in the poorly defined marginal zones. In large field surveys, dose response tests are constrained by a waiting period, obtaining 2 or more biological samples, and use of sophisticated instrumentation. They should be used on a subsample of the population studied.
KW  - Nutrition surveys
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - American Institute of Nutrition
KW  - nutritional surveys
KW  - United States of America
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Methods for assessment of vitamin A status.
AU  - Underwood, B. A.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1990///
VL  - 120
IS  - 11 suppl.
SP  - 1459
EP  - 1463
SN  - 0022-3166
AD  - Underwood, B. A.: Office of International Program Activities, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911429617.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 24 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Commonly used indicators of vitamin A status include dietary intakes of the vitamin, serum levels, and dark adaptation; all have limitations in their precision, especially when applied to individuals and to young children. New and developing non-clinical indicators include the relative dose response test or a modification of it, conjunctival impression cytology, and isotope dilution to estimate total body reserves. Currently, the most reliable assessment of vitamin A status occurs when a combination of methods is used.
KW  - estimation
KW  - Retinol
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - American Institute of Nutrition
KW  - axerophthol
KW  - status
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Familial goiter in bongo antelope (Tragelaphus eurycerus).
AU  - Doi, S.
AU  - Shifrin, S.
AU  - Santisteban, P.
AU  - Montali, R. J.
AU  - Schiller, C.
AU  - Bush, M.
AU  - Grollman, E. F.
JO  - Endocrinology (Philadelphia)
JF  - Endocrinology (Philadelphia)
Y1  - 1990///
VL  - 127
IS  - 2
SP  - 857
EP  - 864
SN  - 0013-7227
AD  - Doi, S.: E. Grollman, National Institutes of Health, Building 10, Room 9B12, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911428981.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - Congenital defects in thyroglobulin (Tg) synthesis in animals have proven to be useful models for the study of Tg synthesis and regulation. Defects in Tg synthesis have been well described in Afrikander cattle, Australian Merino sheep, and goats in the Netherlands. A study of goitre in a non-domesticated species, bongo antelope (Tragelaphus eurycerus), an African bovid, is described. Three bongos housed at the National Zoological Park, Washington, DC, USA, were studied; two had visible goitres and a third had microscopic evidence of goitre. Tg extracted from thyroid glands or thyroid colloid had a high molecular weight (mol. wt.) component that was greater than 220 Kdaltons and differed in apparent mol. wt. from 19S Tg from domestic cattle. Thyroid extracts also had thyroid albumin; albumin was more than half the total protein in colloid extract. The bongos with goitre were euthyroid according to their circulating values of thyroid hormones.
KW  - Goitre
KW  - antelopes
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - goiter
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Altered glucagon- and catecholamine hormone-sensitive adenylyl cyclase responsiveness in rat liver membranes induced by manipulation of dietary fatty acid intake.
AU  - Dax, E. M.
AU  - Partilla, J. S.
AU  - Piñeyro, M. A.
AU  - Gregerman, R. I.
JO  - Endocrinology (Philadelphia)
JF  - Endocrinology (Philadelphia)
Y1  - 1990///
VL  - 127
IS  - 5
SP  - 2236
EP  - 2240
SN  - 0013-7227
AD  - Dax, E. M.: Endocrinology Section, Gerontology Research Center, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, MD 21224, USA.
N1  - Accession Number: 19921453053.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 9012-42-4, 9007-92-5.  Subject Subsets: Human Nutrition
N2  - Glucagon- and β-adrenergic-stimulated receptor-adenylyl cyclase systems were examined in liver membranes of male Wistar rats given diets of maize oil as the only source of fatty acids (unsaturated fat diet), hydrogenated coconut oil (saturated fat, essential fatty acid-deficient), or coconut oil plus a minimum required proportion of maize oil to prevent deficiency. Basal and maximal non-receptor mediated adenylyl cyclase activity was the same in membranes of each of the dietary groups. Because β-adrenergic and glucagon receptors in the same membrane use the same coupling components, β-adrenergic stimulated adenylyl cyclase was studied concomitantly with glucagon-stimulated adenylylcyclase to examine whether the receptors per se were responsible for altered hormone response or whether only the Gs guanine nucleotide-sensitive coupling protein interactions or the adenylyl cyclase catalytic unit were influenced by dietary manipulations. The results demonstrate that alterations in the glucagon-stimulated adenylyl cyclase response differ from those in the β-adrenergic adenylyl cyclase response. Furthermore, they suggest that although direct activations of the catalytic unit or its interaction with the guanine nucleotide-sensitive protein do not appear to be affected, hormone receptor-mediated adenylyl cyclase activity may be altered by these dietary manipulations.
KW  - Adenylate cyclase
KW  - beta-Adrenergic agonists
KW  - Coconut oil
KW  - fatty acids
KW  - Glucagon
KW  - intake
KW  - liver
KW  - Maize oil
KW  - Saturated fatty acids
KW  - sources
KW  - Unsaturated fatty acids
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - corn oil
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921453053&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A developmentally regulated, cyclic-AMP inducible gene expressed by metacyclic trypomastigotes of Trypanosoma cruzi.
AU  - Heath, S.
AU  - Vernick, K.
AU  - Hieny, S.
AU  - Sher, A.
JO  - UCLA Symposia on Molecular and Cellular Biology
JF  - UCLA Symposia on Molecular and Cellular Biology
Y1  - 1990///
VL  - 130
SP  - 27
EP  - 33
CY  - New York; USA
PB  - Wiley-Liss Inc
SN  - 0471567647
AD  - Heath, S.: Immunology and Cell Biology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874796.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 19 ref. Subject Subsets: Protozoology
KW  - development
KW  - Developmental stages
KW  - drugs
KW  - molecular biology
KW  - molecular genetics
KW  - parasites
KW  - vaccines
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - biochemical genetics
KW  - growth phase
KW  - medicines
KW  - pharmaceuticals
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Breast feeding protects infants in Indonesia against illness and weight loss due to illness.
AU  - Launer, L. J.
AU  - Habicht, J. P.
AU  - Kardjati, S.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1990///
VL  - 131
IS  - 2
SP  - 322
EP  - 331
SN  - 0002-9262
AD  - Launer, L. J.: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, EPN Rm 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931466268.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Human Nutrition
N2  - The hypothesis that breast feeding modifies the effect of morbidity on growth was tested by examining, at different levels of breast feeding: number of days ill; and relation between morbidity and weight change. A total of 200 observations made at 3-weekly intervals between 1983 and 1984 on 33 normal-birth-weight breast-fed infants from a rural village on the island of Madura, Indonesia were used. Levels of breast feeding were defined as quartiles (Q1-Q4) of proportion of household visit time spent breast feeding. Regression analysis and analysis of variance were used and within child effects examined. Number of days ill from respiratory tract illness decreased significantly (P=0.01) as quartile of breast feeding increased. Weight change was not affected by respiratory tract illness in Q2-Q4 but was significantly and negatively affected by such illness in the lowest quartile, Q1(β= -22.5±4.8g/day ill). Slopes of Q2-Q4 were not significantly different but were significantly different (P=0.0094) from the Q1 slope. Measurement, reverse causality, or confounding bias did not change the interpretation of findings. It is concluded that that breast feeding protects infants against nutritional consequences of illness by decreasing the number of days with respiratory tract illness and protecting against weight loss due to this form of illness. However the protective effect of breast feeding was attained only when levels of breast feeding were adequate, as at the lowest level of breast feeding, illness had a negative impact on weight performance.
KW  - Breast feeding
KW  - Diet studies
KW  - Growth
KW  - Health
KW  - Infants
KW  - Morbidity
KW  - Respiratory diseases
KW  - Weight losses
KW  - Indonesia
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - lung diseases
KW  - Diet Studies (VV110) 
KW  - Human Nutrition (General) (VV100) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer mortality and lipid and lipoprotein levels. The lipid research clinics program mortality follow-up study.
AU  - Cowan, L. D.
AU  - O'Connell, D. L.
AU  - Criqui, M. H.
AU  - Barrett-Connor, E.
AU  - Bush, T. L.
AU  - Wallace, R. B.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1990///
VL  - 131
IS  - 3
SP  - 468
EP  - 482
SN  - 0002-9262
AD  - Cowan, L. D.: Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Federal Building, Room 401, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931454624.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - The associations of serum lipid and lipoprotein levels with the risk of cancer mortality were assessed in 2753 men and 2476 women 40 to 79 years old at baseline (1972 to 1976) who participated in the Lipid Research Clinics Programme Mortality Follow-up Study until 1984. 79 cancer deaths occurred in men and 65 occurred in women during an average follow-up time of 8.4 years. Total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly inversely associated with overall cancer mortality in men, but no relation was observed in women. Neither high-density lipoprotein (HDL) cholesterol nor triacylglycerols were significantly related to total cancer mortality in either sex, although in women, HDL cholesterol was positively associated with risk of death from gynaecological cancers. Compared with men with higher cholesterol levels, the relative risk of death from colon cancer, adjusted for age, body mass, cigarette smoking and alcohol consumption, was 5.20 (95% confidence interval (CI) 1.61 to 16.8) in men with total cholesterol levels ≤187 mg/100 ml and 4.79 (95% CI 1.37 to 16.8) in those with LDL cholesterol levels ≤119 mg/100 ml. Death from smoking-related cancers was inversely related to baseline total cholesterol but not to LDL cholesterol. The absence of an association with HDL cholesterol which has been shown to be lower in persons with clinically manifest malignancy, and evidence from survival curves suggest that the inverse relation in men is not due to preexisting disease.
KW  - Blood
KW  - Blood lipids
KW  - Carcinoma
KW  - Lipoproteins
KW  - Mortality
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - death rate
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931454624&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of vitamin and mineral supplements: demographics and amounts of nutrients consumed. The 1987 Health Interview Survey.
AU  - Subar, A. F.
AU  - Block, G.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1990///
VL  - 132
IS  - 6
SP  - 1091
EP  - 1101
SN  - 0002-9262
AD  - Subar, A. F.: National Institutes of Health, National Cancer Institute, Division of Cancer Prevention and Control, 9000 Rockville Pike, EPN 313, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921445075.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - Data from the 1987 National Health Interview Survey showed that 51.1% of the adults aged 18-99 years in the United States had consumed a vitamin/mineral supplement in the previous year, but that only 23.1% did so daily. Whites, women, and older individuals were more likely than blacks, men and younger individuals to consume supplements regularly. Multivitamins were the most commonly consumed supplement, followed by vitamin C, calcium, vitamin E and vitamin A. Results suggest that supplementation practices have changed little since the 1970s. Results regarding the amounts of nutrients obtained from supplements showed that a food frequency type of methodology collects reasonably accurate data reflecting intake of supplements over the previous year. Few, if any, individuals were consuming nutrients in amounts considered toxic. Although vitamin and mineral supplementation is a common health habit, it appears not to pose a significant health risk for most of the population.
KW  - Diet studies
KW  - ethnic groups
KW  - intake
KW  - mineral supplements
KW  - Minerals
KW  - sex differences
KW  - vitamin supplements
KW  - Vitamins
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria.
AU  - Vinetz, J. M.
AU  - Kumar, S.
AU  - Good, M. F.
AU  - Fowlkes, B. J.
AU  - Berzofsky, J. A.
AU  - Miller, L. H.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1990///
VL  - 144
IS  - 3
SP  - 1069
EP  - 1074
SN  - 0022-1767
AD  - Vinetz, J. M.: L.H. Miller, Laboratory of Parasitic Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873232.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology
N2  - To further examine the mechanisms of CD8+ T cell involvement in immunity to blood stage P. yoelii infection, in vivo CD8 depletion and adoptive transfer experiments were performed. Depletion of CD8+ T cells during primary blood stage infection in BALB/c mice did not diminish the ability of the mice to resolve their infections. Spleen cells from immune BALB/c and C57BL/10 mice were transferred to BALB/c-nu/nu and C57BL/10-nu/nu mice, respectively. The recipient mice were CD4 depleted in vivo to kill any transferred CD4+ T cells. The mice failed to control the infection. Populations of CD4-, CD8+ T cells were transferred from immune CBA/CaJ donors to in vivo CD4-depleted CBA/CaJ recipients. The mice were unable to control the infection. Although immune unfractionated spleen cells transferred rapid protection in all 3 mouse strains and immune CD4+ T cells transferred immunity in the 2 mouse strains studied, CD8+ T cells by themselves were neither protective nor did they enhance immunity.
KW  - immunity
KW  - Laboratory animals
KW  - parasites
KW  - Spleen cells
KW  - T lymphocytes
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium yoelii
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - The identification of an Onchocerca-specific recombinant antigen containing a T cell epitope.
AU  - Colina, K. F.
AU  - Perler, F. B.
AU  - Matsumura, I.
AU  - Meda, M.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1990///
VL  - 145
IS  - 5
SP  - 1551
EP  - 1556
SN  - 0022-1767
AD  - Colina, K. F.: T.B. Nutman, Building 4, Room 126, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873721.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Helminthology
N2  - Recombinant Onchocerca volvulus antigens (Ag) were derived from expression libraries and examined for their ability to stimulate peripheral blood mononuclear cells (PBMC) from patients infected with O. volvulus. Ten clones producing recombinant Ag were selected and plaque purified; lysogens were produced and found to express β-galactosidase fusion proteins ranging from 115 to 138 000 MW. When ammonium sulfate-precipitated lysates of these recombinant phage clones were examined for their ability to stimulate PBMC from a patient with onchocerciasis, all 10 recombinants produced stimulation above that to nonrecombinant phage. When individual fusion proteins, affinity purified on anti-β-galactosidase linked to agarose, were used to stimulate PBMC from patients with onchocerciasis, only one of the recombinant Ag induced PBMC proliferation (stimulation index &gt;4) above that to Ag from nonrecombinant phage. Characterization of the DNA coding for this antigen showed it to be 1.2 kb in length with a small (90 bp) open reading frame; furthermore, it appeared to be Onchocerca specific (on genomic dot blots) and single copy. Using overlapping peptides encompassing the entire open reading frame, one T cell epitope was localized.
KW  - antigens
KW  - Biotechnology
KW  - Developmental stages
KW  - Filariids
KW  - helminths
KW  - immune response
KW  - Molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - peripheral blood mononuclear cells
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - growth phase
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - recombinant antigen
KW  - Secernentea
KW  - Spirurida
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.
AU  - Sher, A.
AU  - Coffman, R. L.
AU  - Hieny, S.
AU  - Cheever, A. W.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1990///
VL  - 145
IS  - 11
SP  - 3911
EP  - 3916
SN  - 0022-1767
AD  - Sher, A.: Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873388.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 37341-29-0.  Subject Subsets: Helminthology
N2  - To investigate the role of anaphylactic immune responses in protective immunity against schistosomiasis, mice vaccinated with irradiated cercariae of S. mansoni (NMRI strain) were treated with neutralizing MAbs against either IL-5 or IL-4 before and during challenge infection. Anti-IL-5-treated vaccinated mice showed a complete ablation of circulating as well as tissue eosinophils, present in inflammatory reactions to migrating schistosomula in the skin and lungs, but nevertheless eliminated challenge infections as effectively as vaccinated animals treated with a control MAb. Similarly, treatment of vaccinated mice with an anti-IL-4 MAb markedly reduced serum IgE although failing to diminish immunity. The effect of anti-IL-5 mediated eosinophil depletion was also assessed in a 2nd model in which resistance is induced by concomitant chronic infection. Again, normal, unaltered protection was observed in the absence of circulating and tissue eosinophils. In contrast to the above findings, treatment with anti-IFN-γ was found to cause a partial depletion of immunity in vaccinated mice while, paradoxically, increasing the numbers of inflammatory reactions against invading schistosomula in the lungs. These observations argue against a requirement for either eosinophils or IgE in the anti-schistosome immunity induced by vaccination with irradiated cercariae, or for eosinophils in the resistance resulting from previous infection in mice, and support previous data suggesting a role for an IFN-γ dependent cell-mediated effector mechanism in vaccine-induced resistance.
KW  - eosinophils
KW  - Experimental infections
KW  - helminths
KW  - Human diseases
KW  - IgE
KW  - immune response
KW  - Immunity
KW  - Laboratory animals
KW  - parasites
KW  - Digenea
KW  - mice
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - eosinophil leukocytes
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - B cell responses to paramyosin. Isotypic analysis and epitope mapping of filarial paramyosin in patients with onchocerciasis.
AU  - Steel, C.
AU  - Limberger, R. J.
AU  - McReynolds, L. A.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1990///
VL  - 145
IS  - 11
SP  - 3917
EP  - 3923
SN  - 0022-1767
AD  - Steel, C.: Building 4, Room 126, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873389.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Helminthology
N2  - To examine the fine specificity of the human immune response to filarial paramyosin, the antigenicity of an expressed rcDNA (2.55 kb) of Dirofilaria immitis paramyosin was detailed by ELISA. Using sera from patients infected with Onchocerca volvulus, both the entire paramyosin molecule and 6 subcloned fragments were analysed for their IgG, IgG subclasses, and IgE responses. Patients from both Guatemala (64% positive) and Ghana (100% positive) reacted to paramyosin with specific IgG levels above normal controls. Although there was no anti-paramyosin subclass restriction common to all patients, the IgG3 response in the Ghanaians was signficantly greater than that of Guatemalans. IgE anti-paramyosin responses showed positive correlations with IgG2, IgG4 and IgG1 responses. Epitope mapping using the IgG response to the 6 subclones demonstrated preferential recognition of the amino terminal end of the molecule (nucleotides 1 to 360). IgG2 reactivity was clearly localized to the most amino-terminal 120 amino acids, and the IgG4 antibodies recognized amino acids immediately adjacent to this fragment. These studies examining the fine specificity of anti-filarial immune reactions should provide a method for understanding how parasites either evade or induce host immune responses.
KW  - antigens
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - parasites
KW  - Dirofilaria immitis
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Dirofilaria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - paramyosin
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cell-mediated immune response to schistosomiasis.
AU  - James, S. L.
AU  - Sher, A.
T2  - Current Topics in Microbiology and Immunology
Y1  - 1990///
VL  - 155
SN  - 0070-217X
AD  - James, S. L.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900863794.  Publication Type: Journal Article; Book chapter; Journal article.  Language: English.  Number of References: 38 ref. Subject Subsets: Helminthology
N2  - T-cell mediated immunity in the resistance to and the pathogenesis of schistosomiasis are considered, and the hypothesis that a functional dichotomy exists in the role of TH subsets in the resistance to and pathology of helminth infections is discussed.
KW  - Cell mediated immunity
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - immunopathology
KW  - parasites
KW  - resistance
KW  - T lymphocytes
KW  - Digenea
KW  - Schistosoma
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - cellular immunity
KW  - discussed
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863794&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resistance of scrapie infectivity to steam autoclaving after formaldehyde fixation and limited survival after ashing at 360°C: practical and theoretical implications.
AU  - Brown, P.
AU  - Liberski, P. P.
AU  - Wolff, A.
AU  - Gajdusek, D. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1990///
VL  - 161
IS  - 3
SP  - 467
EP  - 472
SN  - 0022-1899
AD  - Brown, P.: Bldg. 36, Room 5B21, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19902213690.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 50-00-0.  Subject Subsets: Veterinary Science; Veterinary Science; Public Health
N2  - Scrapie-infected hamster brains and their extracted amyloid fibrils were subjected to formaldehyde and steam autoclaving, alone or in combination. Treatment with formaldehyde before autoclaving stabilized infectivity, whereas treatment after autoclaving rendered the tissue or extracts inactive or further reduced infectivity. In additional experiments on specimens (not treated with formaldehyde) that were subjected to dry heat, a small amount of infectivity still survived a 1-hour exposure to temperatures as high as 360°C. These results are consistent with the operation of a comparatively primitive molecular mechanism for the initiation of scrapie agent replication (perhaps an inorganic crystal nucleation step) and the subsequent participation of an organic macromolecule (scrapie amyloid protein) that is susceptible to intramolecular cross-stabilization by formaldehyde.
KW  - Ashing
KW  - Autoclaving
KW  - cat diseases
KW  - disinfection
KW  - Formaldehyde
KW  - Heat
KW  - Prion proteins
KW  - Scrapie agent
KW  - viral diseases
KW  - cats
KW  - Hamsters
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - prions
KW  - brain tissue
KW  - formaldehyde and autoclaving
KW  - viral infections
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of preventive, early, and late antifungal chemotherapy with fluconazole in different granulocytopenic models of experimental disseminated candidiasis.
AU  - Walsh, T. J.
AU  - Aoki, S.
AU  - Mechinaud, F.
AU  - Bacher, J.
AU  - Lee, J.
AU  - Rubin, M.
AU  - Pizzo, P. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1990///
VL  - 161
IS  - 4
SP  - 755
EP  - 760
SN  - 0022-1899
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19911207962.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - To investigate the potential use of fluconazole for prevention and treatment of disseminated Candida albicans infections in granulocytopenic patients, its in vivo antifungal activity was studied in 3 models of disseminated candidosis in persistently granulocytopenic rabbits: acute, subacute and chronic disseminated candidosis. Fluconazole was compared with the combination of amphotericin B and flucytosine for preventive, early and late treatment of disseminated candidosis, depending on the model. Fluconazole was most effective when used for preventive or early treatment of acute and subacute disseminated candidosis. When compared with the combination of amphotericin B plus flucytosine, fluconazole was similarly effective in early treatment of acute and subacute disseminated candidosis. When treatment was delayed 6 d after established infection, fluconazole was less active in clearing tissues in comparison with its activity in preventive and early treatment. The combination of amphotericin B plus flucytosine, however, was significantly more active than fluconazole in treatment of chronic disseminated candidosis in all tissues. It is concluded that fluconazole is most effective against disseminated candidosis in persistently granulocytopenic rabbits when used for prevention or early treatment.
KW  - amphotericin B
KW  - Antifungal agents
KW  - fluconazole
KW  - flucytosine
KW  - generalized infections
KW  - infections
KW  - predisposition
KW  - prophylaxis
KW  - therapy
KW  - Candida albicans
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - 5-fluorocytosine
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Granulocyte-macrophage colony-stimulating factor augments human monocyte fungicidal activity for Candida albicans.
AU  - Smith, P. D.
AU  - Lamerson, C. L.
AU  - Banks, S. M.
AU  - Saini, S. S.
AU  - Wahl, L. M.
AU  - Calderone, R. A.
AU  - Wahl, S. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1990///
VL  - 161
IS  - 5
SP  - 199
EP  - 1005
SN  - 0022-1899
AD  - Smith, P. D.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19901207158.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The ability of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) to augment the fungicidal activity of human monocytes for C. albicans was evaluated. Purified human monocytes cultured with [³H]leucine-labelled C. albicans caused a dose-dependent release of the [³H]leucine. The amount of [³H]leucine released correlated with a decrease in the number of viable yeast colonies. Monocyte cytotoxicity for C. albicans was reduced by superoxide dismutase and catalase and by inhibitors of myeloperoxidase and scavengers of hydroxyl radical and singlet oxygen, consistent with monocyte candidacidal activity being partly dependent upon products of oxidative metabolism. Monocytes incubated with rhGM-CSF produced more superoxide anion (O2-) spontaneously and after stimulation than control monocytes (P&lt;0.05). Enhanced O2- production was dose-dependent and specific for rhGM-CSF and could be inhibited by antibody to rhGM-CSF. In association with rhGM-CSF-induced production of O2-, the cytokine enhanced cytotoxic activity for C. albicans. It is concluded that rhGM-CSF stimulates human monocyte fungicidal activity for C. albicans.
KW  - immunology
KW  - monocytes
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207158&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Candida albicans in patients with the acquired immunodeficiency syndrome: absence of a novel or hypervirulent strain.
AU  - Whelan, W. L.
AU  - Kirsch, D. R.
AU  - Kwon-Chung, K. J.
AU  - Wahl, S. M.
AU  - Smith, P. D.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1990///
VL  - 162
IS  - 2
SP  - 513
EP  - 518
SN  - 0022-1899
AD  - Whelan, W. L.: P. D. Smith, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911208311.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - To determine whether C. albicans in patients with AIDS represents a unique strain, C. albicans isolated from 24 patients with AIDS was compared with Candida isolated from 23 healthy adults. Resistance to 5-fluorocytosine [flucytosine], synthesis of amino acids and nucleotides, sugar use and enzyme activity patterns were similar among isolates from the 2 groups. Molecular analysis revealed similar banding patterns of EcoRI restriction fragments of DNA between 2.5-3 and 6-7 kb. In addition, the frequency of a dimorphic 3.7- versus 4.2-kb band, identified by agarose gel electrophoresis and by probing Southern transfers of EcoRI digests with a cloned fragment of C. albicans DNA encoding 25S ribosomal RNA, was not significantly different between the AIDS-derived and control C. albicans. C. albicans isolated at different time points in the course of disease and from different sites in individual patients showed identical DNA fingerprints. It is concluded that the similarity in isolates of C. albicans that cause disease in AIDS patients and those present in healthy subjects indicate that the candidosis associated with AIDS is not due to the presence of an unique or particularly virulent strain but is likely the consequence of a defect in host defence mechanisms.
KW  - acquired immune deficiency syndrome
KW  - biotypes
KW  - candidosis
KW  - clinical aspects
KW  - DNA
KW  - epidemiology
KW  - genetics
KW  - hosts
KW  - infections
KW  - isolation
KW  - mouth
KW  - oesophagus
KW  - Opportunistic infections
KW  - Pathology
KW  - phenotypes
KW  - predisposition
KW  - restriction fragment length polymorphism
KW  - USA
KW  - Candida albicans
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - candidiasis
KW  - clinical picture
KW  - deoxyribonucleic acid
KW  - esophagus
KW  - fungus
KW  - Hyphomycetes
KW  - RFLP
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208311&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Normal and deficient neutrophils can cooperate to damage Aspergillus fumigatus hyphae.
AU  - Rex, J. H.
AU  - Bennett, J. E.
AU  - Gallin, J. I.
AU  - Malech, H. L.
AU  - Melnick, D. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1990///
VL  - 162
IS  - 2
SP  - 523
EP  - 528
SN  - 0022-1899
AD  - Rex, J. H.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911208313.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Using a metabolic test of hyphal viability, the interaction between neutrophils and Aspergillus hyphae was investigated over a broad range of hyphae-to-neutrophil ratios. Normal neutrophils were found to damage hyphae whereas neutrophils from patients with both chronic granulomatous disease (CGD) and myeloperoxidase (MPO) deficiency did not. Further, both azide and catalase + superoxide dismutase inhibited the ability of normal neutrophils to damage hyphae, indicating that this damage is mediated by products of the respiratory burst and by the MPO-halide system. Also, mixtures of small numbers of normal neutrophils with larger numbers of CGD neutrophils (range, 1:5 to 1:15) damaged hyphae more efficiently than either population of cells alone. Further, mixtures of CGD and MPO-deficient neutrophils, neither of which alone could efficiently damage hyphae, were able to damage the hyphae almost as well as a comparable number of normal neutrophils. It is concluded that intact neutrophils can cooperate to synergistically damage Aspergillus hyphae, possibly by extracellular mixing of hydrogen peroxide and MPO.
KW  - immunology
KW  - neutrophils
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208313&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Flucytosine interference in creatinine assay.
AU  - Bennett, J. E.
AU  - Kroll, M. H.
AU  - Washburn, R. G.
T2  - Journal of Infectious Diseases
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1990///
VL  - 162
IS  - 2
SP  - 571
EP  - 572
SN  - 0022-1899
AD  - Bennett, J. E.: Laboratory of Clinical Investigation and Clinical Chemistry Department, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931214400.  Publication Type: Correspondence.  Language: English.  Number of References: 4 ref. Registry Number: 60-72-5, 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - In reply to a previous report [Kennedy, C. A. (et al.) Journal of Infectious Diseases (1989) 160, 1090-1091], it is noted that flucytosine interference with the old EKTACHEM serum creatinine assay is well known to clinical chemistry laboratories and that most now use the new "one-slide" method which has no interference from flucytosine.
KW  - antagonism
KW  - Antifungal agents
KW  - creatinine
KW  - Flucytosine
KW  - 5-fluorocytosine
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214400&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Thin-walled cavities, cysts, and pneumothorax in Pneumocystis carinii pneumonia: further observations with histopathologic correlation.
AU  - Feuerstein, I. M.
AU  - Archer, A.
AU  - Pluda, J. M.
AU  - Francis, P. S.
AU  - Falloon, J.
AU  - Masur, H.
AU  - Pass, H. I.
AU  - Travis, W. D.
JO  - Radiology
JF  - Radiology
Y1  - 1990///
VL  - 174
IS  - 3
SP  - 697
EP  - 702
SN  - 0033-8419
AD  - Feuerstein, I. M.: Diagnostic Radiology Department, Warren G. Magnuson Clinical Center, Bldg 10, Rm 1C660, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910870294.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology
N2  - Thin-walled pulmonary cystic lesions were found in 5 immunocompromised patients from the USA, 4 with AIDS. Four patients had P. carinii pneumonia, and one had pulmonary lesions and disseminated P. carinii infection. Two patients demonstrated P. carinii within necrotizing, thin-walled, smaller intraparenchymal cavities lined by organisms, exudate, and chronic inflammation. Pneumothorax in the 4 patients with AIDS could not be cured by closed thoracostomy drainage; all required pleurodesis.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - case reports
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Lungs
KW  - Opportunistic infections
KW  - parasites
KW  - pneumothorax
KW  - Respiratory diseases
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - lung diseases
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910870294&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of NaCl, glucose, and aldose reductase inhibitors on cloning efficiency of renal medullary cells.
AU  - Yancey, P. H.
AU  - Burg, M. B.
AU  - Bagnasco, S. M.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1990///
VL  - 258
IS  - 1 Pt 1
SP  - C156
EP  - C163
SN  - 0002-9513
AD  - Yancey, P. H.: M. B. Burg, Bldg. 10, Rm 6N307, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921448371.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 50-99-7, 7647-14-5, 50-70-4.  Subject Subsets: Human Nutrition
N2  - To analyse the effects of sorbitol accumulation on the survival and growth of epithelial cells from rabbit renal inner medulla, cloning efficiency (an index of cell viability) was estimated at normal and high glucose and NaCl concentrations and when sorbitol accumulation was prevented by Tolrestat and Sorbinil, which inhibit aldose reductase. With PAP-HT25 cells grown to near confluence, high NaCl increases aldose reductase activity, causing enough rise in cell sorbitol concentration to balance most of the increased osmolality of the high extracellular NaCl. Inhibition of aldose reductase prevents both the increased enzyme activity and sorbitol accumulation in a dose-related manner. Paralleling this, colony-forming efficiency is not affected by the inhibitors at a normal NaCl concentration but is greatly reduced when extracellular NaCl is high. On the other hand, high glucose levels, as occur in diabetes, increase sorbitol content well above the concentration required for osmotic balance and inhibit colony-forming efficiency. Under those conditions, aldose reductase inhibitors lower cell sorbitol and reverse (at 300 to 350 mosmol/kg H2O) or reduce (at 500 to 550 mosmol/kg H2O) the decrease in colony-forming efficiency caused by high glucose. Thus, sorbitol accumulation is necessary for osmoregulation when induced by high osmolality but is harmful when induced by high glucose.
KW  - cell cultures
KW  - cells
KW  - enzyme inhibitors
KW  - glucose
KW  - Kidneys
KW  - sodium chloride
KW  - sorbitol
KW  - cloning
KW  - dextrose
KW  - NaCl
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448371&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ.
AU  - Zurlo, F.
AU  - Lillioja, S.
AU  - Esposito del Puente, A.
AU  - Nyomba, B. L.
AU  - Raz, I.
AU  - Saad, M. F.
AU  - Swinburn, B. A.
AU  - Knowler, W. C.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1990///
VL  - 259
IS  - 5,I
SP  - E650
EP  - E657
SN  - 0002-9513
AD  - Zurlo, F.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19921450289.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
N2  - The 24-h respiratory quotient (RQ) was measured in 152 non-diabetic Pima Indians fed a weight-maintenance diet (87 males and 65 females; 27±6 years (mean±standard deviation); 93.9±22.9 kg body weight; 32±9% fat). The RQ varied from 0.799 to 0.903. Prior change in body weight, 24-h energy balance, sex, and percent body fat explained 18% of the variance in RQ (P&lt;0.001). In a subgroup of 66 siblings from 28 families, family membership explained 28% of the remaining variance in RQ (P&lt;0.05). In 111 subjects for whom follow-up data (25±11 months) were available, RQ was correlated with subsequent changes in body weight and fat mass (r = 0.27, P&lt;0.01 and r = 0.19, P&lt;0.05, respectively). Subjects with higher RQ (90th percentile) independent of 24-h energy expenditure were at 2.5 times higher risk of gaining ≥5 kg body weight than those with lower RQ (10th percentile). It is concluded that, in Pima Indians fed a standard diet, family membership is the principal determinant of the ratio of fat to carbohydrate oxidation, and a low ratio of fat to carbohydrate oxidation is associated with subsequent weight gain independent of low energy expenditure and may contribute to the familial aggregation of obesity.
KW  - body fat
KW  - body weight
KW  - energy exchange
KW  - Ethnic groups
KW  - families
KW  - obesity
KW  - sex differences
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Acanthamoeba myosin I heavy chain kinase is activated by phosphatidylserine-enhanced phosphorylation.
AU  - Brzeska, H.
AU  - Lynch, T. J.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1990///
VL  - 265
IS  - 7
SP  - 3591
EP  - 3594
SN  - 0021-9258
AD  - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920800050.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Protozoology
N2  - It was shown that kinase isolated from Acanthamoeba castellanii by a procedure designed to minimize its phosphorylation during purification can incorporate up to 7.5 mol of phosphate/mol of enzyme when incubated with ATP, possibly by autophosphorylation. The rate of phosphorylation was enhanced about 20-fold by phosphatidylserine but was unaffected by calcium ions. Phosphorylation increased the rate at which the kinase phosphorylates the regulatory site of myosin I by about 50-fold. It is suggested that (auto? )phosphorylation may regulate the activity of myosin I heavy chain kinase in vivo. It is considered that the stimulation of kinase phosphorylation by phosphatidylserine (other phospholipids have not been tested) is of particular interest because myosin I has been shown to be tightly associated with membranes, especially the plasma membrane.
KW  - Biochemistry
KW  - enzymes
KW  - Human diseases
KW  - Kinases
KW  - MYOSINS
KW  - parasites
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800050&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning metabolic pathway genes by complementation in Escherichia coli. Isolation and expression of Plasmodium falciparum glucose phosphate isomerase.
AU  - Kaslow, D. C.
AU  - Hill, S.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1990///
VL  - 265
IS  - 21
SP  - 12337
EP  - 12341
SN  - 0021-9258
AD  - Kaslow, D. C.: Bldg. 4, Rm. BI-37, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900867357.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9001-41-6.  Subject Subsets: Protozoology; Agricultural Biotechnology; Tropical Diseases
N2  - Genetic complementation of an E. coli double mutant was used to isolate and express the gene coding for P. falciparum glucose phosphate isomerase. The gene contains a 1773-base pair open reading frame, has no introns, and maps to P. falciparum chromosome 14. 34% of the deduced amino acid sequence is identical to human glucose phosphate isomerase, with highest similarity in regions of the proposed active sites. The putative initiation site of translation was determined by deletional and oligonucleotide mediated, site-specific mutagenasis. This data suggests that key metabolic enzymes of Plasmodium can be cloned and expressed in E. coli without prior knowledge of the primary amino acid or nucleic acid structure.
KW  - Biotechnology
KW  - gene mapping
KW  - genes
KW  - glucose-6-phosphate isomerase
KW  - Human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Apicomplexa
KW  - Escherichia coli
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - E. coli
KW  - glucose phosphate isomerase
KW  - nucleotide sequence
KW  - phosphoglucose isomerase
KW  - phosphohexose isomerase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900867357&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium.
AU  - Waters, A. P.
AU  - Thomas, A. W.
AU  - Deans, J. A.
AU  - Mitchell, G. H.
AU  - Hudson, D. E.
AU  - Miller, L. H.
AU  - McCutchan, T. F.
AU  - Cohen, S.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1990///
VL  - 265
IS  - 29
SP  - 17974
EP  - 17979
SN  - 0021-9258
AD  - Waters, A. P.: Malaria Section, Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872362.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The complete sequence of the 66 000 MW merozoite surface antigen (PK66) which allowed the demonstration that highly conserved analogues exist throughout P. knowlesi including a recently reported gene from P. falciparum is reported. These analogues are highly promising vaccination candidates. The distribution of PK66 changed after schizont rupture in a coordinate manner associated with merozoite invasion. The protein was concentrated at the apical end prior to rupture, following which it could distribute itself entirely across the surface of the free merozoite. During invasion, immunofluorescence studies suggested that, PK66 is excluded from the erythrocyte at, and behind, the invasion interface.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors report the sequence of a full-length cDNA encoding the Plasmodium knowlesi 66 000 Mr surface antigen (PK66) which is thought to have a role in erythrocyte invasion. Highly conserved analogues exist throughout the genus Plasmodium.Carolyn A. Brown
KW  - antigens
KW  - Biotechnology
KW  - Candidate vaccines
KW  - Developmental stages
KW  - Human diseases
KW  - Malaria
KW  - merozoites
KW  - nucleotide sequences
KW  - parasites
KW  - Proteins
KW  - receptors
KW  - surface antigens
KW  - Vaccines
KW  - Apicomplexa
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - antigenicity
KW  - DNA sequences
KW  - growth phase
KW  - immunogens
KW  - PK66
KW  - surface
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872362&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A new Acanthamoeba myosin heavy chain. Cloning of the gene and immunological identification of the polypeptide.
AU  - Horowitz, J. A.
AU  - Hammer, J. A., III
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1990///
VL  - 265
IS  - 33
SP  - 20646
EP  - 20652
SN  - 0021-9258
AD  - Horowitz, J. A.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804166.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology
N2  - The gene for an Acanthamoeba myosin heavy chain, whose tail domain amino acid sequence distinguishes it from Acanthamoeba myosins IB, IC and II, spans ~6.8 kb, is split by 17 introns, and encodes a 177 000 MW polypeptide. The amino-terminal ~90 000 MW of this polypeptide was highly similar to the globular head sequences of myosins I and II, its ~87 000 MW tail domain shows essentially no similarity to the tail sequences of either type of myosin. The only exception to this is the carboxyl-terminal ~50-amino acid region of the polypeptide, which is homologous to the carboxyl termini of the myosins I. This ~50-residue segment was shown previously to exist in a diverse family of cytoskeleton-associated proteins that included non-receptor tyrosine kinases, phospholipase Cγ, and fodrin. Sequence analysis indicated that the tail domain of this new myosin is incapable of forming a myosin II-like coiled-coil structure. This implies that the protein is single-headed and nonfilamentous, and is tentatively classified as a high MW form of myosin I (HMWMI). To determine whether HMWMI existed in cells, antiserum was raised against a bacterially expressed fusion peptide made using a cDNA clone encoding most of the unique HMWMI tail domain. This antiserum does not recognize Acanthamoeba myosin IB, IC or II but does recognize a single polypeptide in whole cell extracts with the mobility predicted for the HMWMI heavy chain. The protein is precipitated from crude extracts using F-actin and released from the pellet by ATP, which supported its classification as a member of the myosin family of proteins.
KW  - Complementary DNA
KW  - Genes
KW  - Human diseases
KW  - Molecular genetics
KW  - MYOSINS
KW  - Nucleotide sequences
KW  - parasites
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - cDNA
KW  - Cloning
KW  - DNA sequences
KW  - myosin
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of essential fatty acid deficiency on the adrenergic activation of glycogenolysis in rat hepatocytes.
AU  - Grojec, M. S.
AU  - Ishac, E. J. N.
AU  - Kapocsi, J.
AU  - Kunos, G.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1990///
VL  - 283
IS  - 1
SP  - 34
EP  - 39
SN  - 0003-9861
AD  - Grojec, M. S.: G. Kunos, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, 12501 Washington Avenue, Rockville, MD 20852, USA.
N1  - Accession Number: 19911437055.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - The fatty acid composition of total lipids and the adrenoceptor-mediated activation of glycogenolysis were studied in isolated hepatocytes from male Sprague-Dawley rats fed a standard or an essential fatty acid (EFA)-free diet. In cells from rats on the EFA-free diet there was a marked reduction in linoleic and arachidonic acid (AA) and an increase in eicosatrienoic, oleic, and palmitoleic acid compared to controls. In freshly isolated cells from both groups, phosphorylase a (E.C. 2.4.1.1.) activity was increased by phenylephrine or epinephrine but not by isoprenaline, and the effect of epinephrine was inhibited by phenoxybenzamine but not by propranolol. When control cells were preincubated in a serum-free buffer for 4 h, the effect of phenylephrine on phosphorylase a activity was reduced, isoprenalene became a potent agonist and the effect of epinephrine was partially inhibited either by phenoxybenzamine or by propranolol. The emerging β-adrenergic response in 4-h cells was associated with a marked potentiation of isoprenaline-induced cAMP accumulation. A similar 4-h preincubation of EFA-deficient cells resulted in a reduced response to phenylephrine while isoprenaline was ineffective, for increasing phosphorylase a activity or cAMP production. The response of these 4-h cells to isoprenaline could be restored by in vivo replacement of the EFA-deficient diet with standard chow diet for the last 4 weeks prior to the experiment, but not by the in vitro exposure of the EFA-deficient cells to 10 µM AA throughout the 4-h incubation period. Results suggest that the time-dependent emergence of β-adrenergic glycogenolysis is mediated by AA or its metabolite(s), which probably act by facilitating the G-protein-dependent coupling of β-receptors.
KW  - fat deficiencies
KW  - Glycogenolysis
KW  - liver cells
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - essential fatty acid deficiency
KW  - hepatocytes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis.
AU  - Ottesen, E. A.
AU  - Vijayasekaran, V.
AU  - Kumaraswami, V.
AU  - Pillai, S. V. P.
AU  - Sadanandam, A.
AU  - Frederick, S.
AU  - Prabhakar, R.
AU  - Tripathy, S. P.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1990///
VL  - 322
IS  - 16
SP  - 1113
EP  - 1116
SN  - 0028-4793
AD  - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19950804178.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref. Registry Number: 90-89-1, 1642-54-2, 70288-86-7.  Subject Subsets: Helminthology
N2  - To compare the efficacy and side effects of ivermectin with those of diethylcarbamazine, the standard antifilarial treatment, a randomized double-blind trial in 40 south Indian men with lymphatic filariasis caused by Wuchereria bancrofti was carried out. Patients were randomly assigned to one of 3 treatments. A single low dose (1 mg) of ivermectin followed by placebo for 12 days; a single high dose (6 mg) of ivermectin followed by 12 days of placebo; or diethylcarbamazine (150 mg) for 13 days. At day 12 there was complete clearance of microfilariae from the blood in all 26 men who took ivermectin and in 11 of the 14 men who took diethylcarbamazine. At 6 months the numbers of detectable microfilariae (as a percentage of pre-treatment values) were 18.3% after low-dose ivermectin and 19.5% after high-dose ivermectin, compared with 6% after diethylcarbamazine. Side effects (fever, headache, lethargy and myalgia) were confined to the first 5 days and were similar in all 3 groups. It is concluded that in lymphatic filariasis ivermectin given as a single dose compares favourably with the standard 12-day course of diethylcarbamazine.
KW  - anthelmintics
KW  - diethylcarbamazine
KW  - drug therapy
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - ivermectin
KW  - microfilariae
KW  - parasites
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Wuchereria
KW  - Onchocercidae
KW  - chemotherapy
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease.
AU  - Pekkanen, J.
AU  - Linn, S.
AU  - Heiss, G.
AU  - Suchindran, C. M.
AU  - Leon, A.
AU  - Rifkind, B. M.
AU  - Tyroler, H. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1990///
VL  - 322
IS  - 24
SP  - 1700
EP  - 1707
SN  - 0028-4793
AD  - Pekkanen, J.: B.M. Rifkind, Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, National Institutes of Health, Federal Building, Rm. 401, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901452188.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - A total of 2541 white men, 40 to 69 years old at base line, were followed for on average 10.1 years as part of the Lipid Research Clinics Program Prevalence Study in 10 North American populations between 1972 and 1976; 17% had some manifestation of cardiovascular disease (CVD) at base line. Among the men who had CVD at base line, those with blood cholesterol above 6.19 mmol/litre had a risk of death from CVD, including CHD, 3.45 times higher (95% confidence interval 1.63 to 7.33) than that for men with blood cholesterol below 5.16 mmol/litre. The corresponding hazard ratios were 5.92 (95% confidence interval 2.59 to 13.51) for low-density lipoprotein (LDL) cholesterol concentration above 4.13 mmol/litre as compared with those below 3.35 mmol/litre and 6.02 (95% confidence interval 2.73 to 13.28) for high-density lipoprotein (HDL) cholesterol concentrations below 0.90 mmol/litre as compared with those above 1.16 mmol/litre. All lipid values were also predictors of death from CHD alone. Total cholesterol and LDL cholesterol concentrations were also significant predictors of death from CVD and CHD in men without pre-existing CVD, although at a lower level of absolute risk of death. Thus, the 10-year risk of death from CVD for a man with pre-existing CVD increased from 3.8 to almost 19.6% with increasing levels of total cholesterol from 5.16 to 6.19 whereas the corresponding risk for a man who was free of CVD at base line increased from 1.7 to 4.9%. The findings suggest that total LDL and HDL cholesterol concentrations predict subsequent mortality in men 40 to 69 years old, especially those with pre-existing CVD.
KW  - blood
KW  - Cardiovascular diseases
KW  - cholesterol
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Consensus statement on the use of corticosteroids as adjunctive therapy for Pneumocystis pneumonia in the acquired immunodeficiency syndrome.
AU  - Masur, H.\Meier, P.\McCutchan, J. A.\Feinberg, J.\Bernard, G.\Bozzette, S. A.\Clement, M.\Ellenberg, S. S.\Feigal, D. W.\Gagnon, S.\Mathews, C. W.\Mills, J.\Montaner, J.\Nielsen, J. O.\Sattler, F. R.\Spector, S.\Tilles, J. G.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1990///
VL  - 323
IS  - 21
SP  - 1500
EP  - 1504
SN  - 0028-4793
AD  - H. Masur, Clinical Center 10d48, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910869374.  Publication Type: Journal Article.  Corporate Author: National Institutes of Health-University of California expert panel for corticosteroids as adjunctive therapy for Pneumocystis pneumonia. Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology
N2  - Five recently-completed, randomized trials assessing the efficacy of adjunctive therapy with corticosteroids for AIDS-associated Pneumocystis pneumonia were reviewed by a panel of experts under the sponsorship of the National Institutes of Health and the California Universitywide AIDS Research Program. It was found that 3 of the 5 studies suggest that short-term mortality from Pneumocystis pneumonia is reduced by adjunctive therapy with corticosteroids. Two studies found that steroids prevent further declines in arterial oxygen levels after specific therapy is initiated. The report covers the background and the conceptual basis for assessing the 5 trials, summaries of each of the case studies, the panels' conclusions and recommendations, as well as other issues addressed by the panel (adjunctive corticosteroids in pregnant women with HIV infection or immunosuppressed patients without HIV infection, adjunctive corticosteroids in patients in whom specific anti-Pneumocystis therapy is failing, and other studies that are needed).
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - corticoids
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - treatment
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - corticosteroids
KW  - fungus
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Searching for the yeast connection.
AU  - Bennett, J. E.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1990///
VL  - 323
IS  - 25
SP  - 1766
EP  - 1767
SN  - 0028-4793
AD  - Bennett, J. E.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911207933.  Publication Type: Editorial.  Language: English.  Number of References: 9 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The chronic candidosis syndrome is discussed and it is concluded that scientifically sound studies are needed to determine whether the syndrome does or does not exist.
KW  - allergies
KW  - Candida
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross.
AU  - Wellems, T. E.
AU  - Panton, L. J.
AU  - Gluzman, I. Y.
AU  - Rosario, V. E. do
AU  - Gwadz, R. W.
AU  - Walker-Jonah, A.
AU  - Krogstad, D. J.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1990///
VL  - 345
IS  - 6272
SP  - 253
EP  - 255
SN  - 0028-0836
AD  - Wellems, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19900867389.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0.  Subject Subsets: Protozoology
N2  - Chloroquine is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering with their function. Parasites resistant to chloroquine expel the drug rapidly in an unaltered form, thereby reducing levels of accumulation in the vesicles. The discovery that verapamil partially reverses chloroquine resistance in vitro led to the proposal that efflux may involve an ATP-driven P-glycoprotein pump similar to that in mammalian multidrug-resistant (mdr) tumor cell lines. Indeed, P. falciparum contains at least 2 mdr-like genes, one of which has been suggested to confer the chloroquine resistant (CQR) phenotype. To determine if either of these genes was linked to chloroquine resistance, a genetic cross between CQR and chloroquine susceptible (CQS) clones of P. falciparum was performed. Examination of 16 independent recombinant progeny indicated that the rapid efflux phenotype is controlled by a single gene or a closely linked group of genes. But, there was no linkage between the rapid efflux, CQR phenotype and either of the mdr-like P. falciparum genes or amplification of those genes. The results indicate that the genetic locus governing chloroquine efflux and resistance is independent of the known mdr-like genes.
KW  - Antimalarials
KW  - Antiprotozoal agents
KW  - chloroquine
KW  - drug resistance
KW  - genetics
KW  - Human diseases
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of age on duodenal 1,25-dihydroxyvitamin D-3 receptors in Wistar rats.
AU  - Takamoto, S.
AU  - Seino, Y.
AU  - Sacktor, B.
AU  - Liang, C. T.
JO  - Biochimica et Biophysica Acta (G), General Subjects
JF  - Biochimica et Biophysica Acta (G), General Subjects
Y1  - 1990///
VL  - 1034
IS  - 1
SP  - 22
EP  - 28
AD  - Takamoto, S.: C.T. Liang, Laboratory of Biological Chemistry, National Institute of Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19901451626.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 32222-06-3, 7440-70-2.  Subject Subsets: Human Nutrition
N2  - Previous studies show that duodenal Ca2+ absorption and serum 1,25-dihydroxyvitamin D (1,25-DHD) values decrease with maturity. Receptor preparations from rats 6 and 24 months old, were incubated with ³H-labelled 1,25-dihydroxycholecalciferol (1,25-DHCC) to quantify the number of unoccupied and total receptor sites and showed that total and unoccupied receptor sites decreased by 22 and 16%, respectively, in old rats. Endogenously occupied sites were reduced by 43% in duodenum of the old rat and, consequently, the percentage of receptor, occupancy also declined. Age did not affect the dissociation constant (KD) of 1,25-DHCC from the receptor; the sedimentation coefficient (3.3 S) of the tritiated 1,25-DHCC receptor complex in sucrose density centrifugation or its affinity for DNA. The data are consistent with the hypothesis that the age-related decline in Ca2+ absorption in the intestine may be due, in part, to the decrease in the circulating value of 1,25-DHD and a reduction of intestinal 1,25-DHCC receptor occupancy status.
KW  - absorption
KW  - age
KW  - blood
KW  - calcitriol
KW  - Calcium
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 1,25-dihydroxycholecalciferol
KW  - 1,25-dihydroxyvitamin D
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451626&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Sporotrichosis.
AU  - Bennett, J. E.
A2  - Warren, K. S.
A2  - Mahmoud, A. A. F.
T2  - Tropical and geographical medicine.
JO  - Tropical and geographical medicine.
JF  - Tropical and geographical medicine.
Y1  - 1990///
IS  - Ed. 2
SP  - 1007
EP  - 1008
CY  - New York; USA
PB  - McGraw-Hill, Inc.
SN  - 007068328X
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19911210371.  Publication Type: Miscellaneous.  Language: English.  Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The pathogenesis and pathology, clinical manifestations, differential diagnosis and treatment of Sporothrix schenckii infections are discussed.
KW  - hosts
KW  - infections
KW  - man
KW  - Sporothrix schenckii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Sporothrix
KW  - Ophiostomataceae
KW  - Ophiostomatales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antifungal agents.
AU  - Bennett, J. E.
A2  - Mandell, G. L.
A2  - Douglas, R. G., Jr.
A2  - Bennett, J. E.
T2  - Principles and practice of infectious diseases.
JO  - Principles and practice of infectious diseases.
JF  - Principles and practice of infectious diseases.
Y1  - 1990///
IS  - Ed. 3
SP  - 361
EP  - 370
CY  - New York; USA
PB  - Churchill Livingstone Inc.
SN  - 0443086869
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19931214317.  Publication Type: Miscellaneous.  Language: English.  Number of References: 115 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Major topical antifungal agents including Whitfield's ointment, polyenes and imidazoles, oral antifungals such as griseofulvin, ketoconazole and terbinafine, and treatment of deep mycoses with amphotericin B, flucytosine, ketoconaozle, itraconazole and fluconazole are reviewed.
KW  - Antifungal agents
KW  - reviews
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Aspergillus species.
AU  - Bennett, J. E.
A2  - Mandell, G. L.
A2  - Douglas, R. G., Jr.
A2  - Bennett, J. E.
T2  - Principles and practice of infectious diseases.
JO  - Principles and practice of infectious diseases.
JF  - Principles and practice of infectious diseases.
Y1  - 1990///
IS  - Ed. 3
SP  - 1958
EP  - 1962
CY  - New York; USA
PB  - Churchill Livingstone Inc.
SN  - 0443086869
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19931214319.  Publication Type: Miscellaneous.  Language: English.  Number of References: 79 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The epidemiology, pathogenesis and pathological characteristics, clinical manifestations, involving ear and sinus, eye, lung, central nervous system and other sites, diagnosis and treatment of Aspergillus infections are reviewed.
KW  - hosts
KW  - infections
KW  - reviews
KW  - Aspergillus
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214319&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Sporothrix schenckii.
AU  - Bennett, J. E.
A2  - Mandell, G. L.
A2  - Douglas, R. G., Jr.
A2  - Bennett, J. E.
T2  - Principles and practice of infectious diseases.
JO  - Principles and practice of infectious diseases.
JF  - Principles and practice of infectious diseases.
Y1  - 1990///
IS  - Ed. 3
SP  - 1972
EP  - 1975
CY  - New York; USA
PB  - Churchill Livingstone Inc.
SN  - 0443086869
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19931214321.  Publication Type: Miscellaneous.  Language: English.  Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Mycology, epidemiology, clinical manifestations, diagnosis, treatment and prognosis are discussed for Sporothrix schenckii infections.
KW  - hosts
KW  - infections
KW  - man
KW  - Sporothrix schenckii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Sporothrix
KW  - Ophiostomataceae
KW  - Ophiostomatales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214321&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Miscellaneous fungi.
AU  - Bennett, J. E.
A2  - Mandell, G. L.
A2  - Douglas, R. G., Jr.
A2  - Bennett, J. E.
T2  - Principles and practice of infectious diseases.
JO  - Principles and practice of infectious diseases.
JF  - Principles and practice of infectious diseases.
Y1  - 1990///
IS  - Ed. 3
SP  - 2031
EP  - 2034
CY  - New York; USA
PB  - Churchill Livingstone Inc.
SN  - 0443086869
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19931214330.  Publication Type: Miscellaneous.  Language: English.  Number of References: 71 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Miscellaneous fungal infections, caused by Pseudallescheria boydii, Prototheca spp., Emmonsia crescens, Rhinosporidium seeberi, Loboa loboi, dematiaceous fungi and others, are briefly discussed.
KW  - infections
KW  - Ajellomyces crescens
KW  - Chlorellaceae
KW  - Chlorellales
KW  - Loboa loboi
KW  - Man
KW  - Onygenales
KW  - Prototheca
KW  - Pseudallescheria boydii
KW  - Rhinosporidium seeberi
KW  - Emmonsia
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Loboa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Chlorellaceae
KW  - Chlorellales
KW  - Chlorophyta
KW  - algae
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Sordariomycetes
KW  - Rhinosporidium
KW  - Protozoa
KW  - invertebrates
KW  - Ajellomyces
KW  - Emmonsia crescens
KW  - fungus
KW  - Lacazia
KW  - Lacazia loboi
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214330&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Malaria.
AU  - Miller, L. H.
AU  - Warrell, D. A.
A2  - Warren, K.S.
A2  - Mahmoud, A.A.F.
T2  - Tropical and Geographical Medicine.
Y1  - 1990///
IS  - Ed.2
CY  - New York; USA
PB  - McGraw-Hill, Inc.
SN  - 007068328X
AD  - Miller, L. H.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910874752.  Publication Type: Book chapter.  Language: English.  Number of References: 65 ref. Subject Subsets: Protozoology
N2  - A general account of malaria is given with discussion of the following topics: life cycle in humans; parasite biology, intracellular physiology, and biochemistry; parasite genetics; parasite evolution; patient; innate resistance; immunity to asexual erythrocytic parasites; pathogenesis and pathology; clinical manifestations; treatment; population; epidemiology; malaria control and eradication; malaria research.
KW  - Human diseases
KW  - Malaria
KW  - parasites
KW  - reviews
KW  - tropical medicine
KW  - Apicomplexa
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874752&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Leishmaniasis.
AU  - Neva, F.
AU  - Sacks, D.
A2  - Warren, K.S.
A2  - Mahmoud, A.A.F.
T2  - Tropical and Geographical Medicine.
Y1  - 1990///
IS  - Ed.2
CY  - New York; USA
PB  - McGraw-Hill, Inc.
SN  - 007068328X
AD  - Neva, F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910874756.  Publication Type: Book chapter.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology
N2  - Human infections caused by species of Leishmania are outlined under the headings of: parasite: taxonomy; morphology and ultrastructure; life cycle; in vitro cultivation; patient: pathology; immunology; clinical manifestations; diagnosis; therapy; population: vectors and reservoirs; control.
KW  - Human diseases
KW  - Leishmaniasis
KW  - parasites
KW  - tropical medicine
KW  - Leishmania
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - General account
KW  - leishmaniosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874756&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The filariases and tropical eosinophilia.
AU  - Ottesen, E. A.
A2  - Warren, K.S.
A2  - Mahmoud, A.A.F.
T2  - Tropical and Geographical Medicine.
Y1  - 1990///
IS  - Ed.2
CY  - New York; USA
PB  - McGraw-Hill, Inc.
SN  - 007068328X
AD  - Ottesen, E. A.: Clinical Parasitology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910874770.  Publication Type: Book chapter.  Language: English.  Number of References: 66 ref. Subject Subsets: Helminthology
N2  - The filarial diseases caused by Wuchereria bancrofti, Brugia malayi, B. timori, Loa loa, Mansonella perstans, M. streptocerca and M. ozzardi are discussed in turn. The pathogenesis and pathology, clinical manifestations, treatment, transmission and control of each species, are reviewed.
KW  - Filariasis
KW  - filariids
KW  - helminths
KW  - Human diseases
KW  - parasites
KW  - reviews
KW  - tropical medicine
KW  - Brugia malayi
KW  - Brugia timori
KW  - Loa loa
KW  - man
KW  - Mansonella ozzardi
KW  - Mansonella perstans
KW  - Mansonella streptocerca
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Loa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Mansonella
KW  - Wuchereria
KW  - African eyeworm
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874770&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Trichomoniasis.
AU  - Quinn, T. C.
AU  - Krieger, J. N.
A2  - Warren, K.S.
A2  - Mahmoud, A.A.F.
T2  - Tropical and Geographical Medicine.
Y1  - 1990///
IS  - Ed.2
CY  - New York; USA
PB  - McGraw-Hill, Inc.
SN  - 007068328X
AD  - Quinn, T. C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910874763.  Publication Type: Book chapter.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology
N2  - A comprehensive discussion of trichomoniasis in man is given under the following headings and subheadings: parasite: biology; antigenic analysis; patient: pathophysiology; histopathology; clinical manifestations (sites of infection; infections in women; infections in men; neonatal trichomonal infection; diagnosis); management; population: epidemiology; transmission; control.
KW  - Human diseases
KW  - parasites
KW  - Trichomoniasis
KW  - tropical medicine
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trichomonadidae
KW  - Trichomonas vaginalis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Protozoa
KW  - Trichomonadida
KW  - Sarcomastigophora
KW  - Trichomonas
KW  - Trichomonadidae
KW  - trichomonosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874763&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Perspectives on immunopathology in lymphatic filariasis.
AU  - Ottesen, E. A.
T2  - Proceedings of a seminar on future research needs in lymphatic filariasis, 8-10 October 1990.
JO  - Proceedings of a seminar on future research needs in lymphatic filariasis, 8-10 October 1990.
JF  - Proceedings of a seminar on future research needs in lymphatic filariasis, 8-10 October 1990.
Y1  - 1990///
SP  - 25
EP  - 28
CY  - Pondicherry; India
PB  - Vector Control Research Centre
AD  - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920884397.  Publication Type: Conference paper.  Language: English.  Number of References: 6 ref. Subject Subsets: Helminthology
N2  - The current knowledge of immunopathology in man due to infection with Wuchereria bancrofti and Brugia malayi is discussed. The most significant pathology associated with bancroftian and brugian filariasis is localized in 3 organ systems: the lymphatics (acute inflammation, oedema, hydrocoele, elephantiasis and chyluria), the lung (tropical pulmonary eosinophilia syndrome) and the kidneys (haematuria, proteinuria). It has been suggested that the amount of pathology induced by filarial parasites is proportional to the vigour of the host's immune response.
KW  - filariasis
KW  - filariids
KW  - helminths
KW  - human diseases
KW  - immunopathology
KW  - kidneys
KW  - lungs
KW  - parasites
KW  - pathology
KW  - Brugia malayi
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Wuchereria
KW  - immunopathogenesis
KW  - lymphatics
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920884397&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Ecology of Cryptococcus neoformans and prevalence of its two varieties in AIDS and non-AIDS associated cryptococcosis.
AU  - Kwon-Chung, K. J.
AU  - Varma, A.
AU  - Howard, D. H.
A2  - Bossche, H. vanden
A2  - Mackenzie, D. W. R.
A2  - Cauwenbergh, G.
A2  - Cutsem, J. van
A2  - Drouhet, E.
A2  - Dupont, B.
T2  - Mycoses in AIDS patients.
JO  - Mycoses in AIDS patients.
JF  - Mycoses in AIDS patients.
Y1  - 1990///
SP  - 103
EP  - 113
CY  - New York; USA
PB  - Plenum Press
SN  - 030643704X
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
N1  - Accession Number: 19921212155.  Publication Type: Conference paper.  Language: English.  Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The ecology of C. neoformans, epidemiology of C. neoformans var. neoformans and var. gattii, prevalence of C. neoformans var. gattii among AIDS and non-AIDS patients in the same geographical area, and DNA polymorphism among isolates of C. neoformans serotype A from AIDS and non-AIDS patients are discussed.
KW  - acquired immune deficiency syndrome
KW  - epidemiology
KW  - infections
KW  - predisposition
KW  - Cryptococcus gattii
KW  - Cryptococcus neoformans
KW  - Man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus neoformans
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - AIDS
KW  - Cryptococcus neoformans var. gattii
KW  - fungus
KW  - Mycoses in AIDS patients
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212155&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Immunization of monkeys with baculovirus recombinant-expressed dengue envelope and NS1 glycoproteins induces partial resistance to challenge with homotypic dengue virus.
AU  - Lai, C. J.
AU  - Zhang, Y. M.
AU  - Men, R.
AU  - Bray, M.
AU  - Chanock, R. M.
AU  - Dubois, D. R.
AU  - Eckels, K. H.
A2  - Brown, F.
A2  - Chanock, R.M.
A2  - Ginsberg, H.S.
A2  - Lerner, R.A.
T2  - Vaccines 90: modern approaches to new vaccines including prevention of AIDS.
JO  - Vaccines 90: modern approaches to new vaccines including prevention of AIDS.
JF  - Vaccines 90: modern approaches to new vaccines including prevention of AIDS.
Y1  - 1990///
SP  - 119
EP  - 124
CY  - Cold Spring Harbor, New York; USA
PB  - Cold Spring Harbor Laboratory Press
SN  - 087969341X
AD  - Lai, C. J.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940502928.  Publication Type: Miscellaneous.  Language: English.  Number of References: 9 ref.
N2  - The envelope (E) glycoprotein and the NS1 nonstructural glycoprotein of dengue type-4 virus had been identified as independent protective antigens during studies in mice in which these glycoproteins expressed together or singly by a recombinant vaccinia virus or a baculovirus were evaluated for their protective immunity against lethal dengue challenge. As an extension of the mouse protection studies, rhesus monkeys were immunized by (1) infection with a recombinant vaccinia virus expressing C-M-E-NS1-NS2a (group 1), (2) inoculation with a lysate of insect cells infected with a recombinant baculovirus expressing C-M-E-NS1-NS2a (group 2), (3) inoculation with a lysate of insect cells infected with a recombinant baculovirus expressing only E (group 3), (4) infection with a recombinant vaccinia virus expressing HIV envelope glycoprotein (group 4), and (5) inoculation with a lysate of insect cells infected with wild-type baculovirus (group 5). 1 of 6 monkeys in the 2nd group and 1 of 3 in the 3rd group were completely protected from dengue virus challenge as indicated by absence of viraemia. In addition, another monkey in the 2nd group was viraemic for 1 day as compared to monkeys in the control group whose viraemia lasted 4-6 days. On the other hand, monkeys in groups 1, 4 and 5 all became viraemic, and virus was recovered from blood for 4-6 days. These findings suggest that E with or without NS1 can induce partial protection against virus infection in experimental primates. Group-2 monkeys developed a high level of antibodies to NS1 in response to immunization with a baculovirus-recombinant-infected cell lysate containing E and NS1, but antibodies to E were not detected in the serum of group-2 or group-3 monkeys by RIP. However, some of these animals did develop a low titre of virion-specific antibodies detected by ELISA. Following challenge with virus, unprotected monkeys developed a rapid rise of E (groups 1, 2 and 3) and NS1 (groups 1 and 2) antibodies to a level higher than that attained initially by control monkeys, suggesting that immunization with recombinant-expressed E or E plus NS1, although not completely protective, did prime immunized monkeys for an accelerated immune response to these protective antigens.
KW  - Arboviruses
KW  - Immunization
KW  - Laboratory animals
KW  - Vaccines
KW  - Viral proteins
KW  - Baculovirus
KW  - Dengue virus
KW  - Flavivirus
KW  - Macaca mulatta
KW  - Baculoviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940502928&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Advances in the diagnosis of Pneumocystis carinii pneumonia.
AU  - Kovacs, J. A.
T2  - Aids clinical review 1990.
JO  - Aids clinical review 1990.
JF  - Aids clinical review 1990.
Y1  - 1990///
SP  - 129
EP  - 147
CY  - New York; USA
PB  - Marcel Dekker Journals
SN  - 082478362X
AD  - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910875380.  Publication Type: Miscellaneous.  Language: English.  Number of References: 55 ref. Subject Subsets: Protozoology
N2  - The advances that have recently been made in diagnosing P. carinii pneumonia, including an understanding of which patients are at greatest risk for the development of P. carinii pneumonia, are reviewed. The diagnostic techniques that may be available in the future are briefly discussed.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - diagnosis
KW  - Human diseases
KW  - immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - reviews
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875380&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Management of fungal infections in patients with neoplastic diseases.
AU  - Walsh, T. J.
AU  - Pizzo, P. A.
A2  - Ryley, J. F.
T2  - Chemotherapy of fungal diseases.
JO  - Chemotherapy of fungal diseases.
JF  - Chemotherapy of fungal diseases.
Y1  - 1990///
SP  - 399
EP  - 419
CY  - Berlin; Germany
PB  - Springer-Verlag
SN  - 3540522328
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatrics Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19901207611.  Publication Type: Miscellaneous.  Language: English.  Number of References: 84 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The treatment of fungal infections in patients with neoplastic diseases is reviewed. Management of nosocomial mycoses caused by Aspergillus flavus, A. fumigatus, agents of phycomycosis, Pseudallescheria boydii, Fusarium, agents of phaeohyphomycosis, Candida, Trichosporon beigelii and Malassezia furfur is included.
KW  - infections
KW  - neoplasms
KW  - phaeohyphomycosis
KW  - predisposition
KW  - therapy
KW  - zygomycosis
KW  - Aspergillus flavus
KW  - Aspergillus fumigatus
KW  - Candida
KW  - Fusarium
KW  - Malassezia furfur
KW  - Man
KW  - Pseudallescheria boydii
KW  - Trichosporon beigelii
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Malassezia
KW  - Malasseziales
KW  - Ustilaginomycotina
KW  - Basidiomycota
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - cancers
KW  - chromomycosis
KW  - fungus
KW  - Hyphomycetes
KW  - phycomycosis
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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ER  - 

TY  - GEN
T1  - Cultivation of Entamoeba histolytica: a historical perspective.
AU  - Diamond, L. S.
A2  - Kretschmer, R.R.
T2  - Amebiasis: infection and disease by Entamoeba histolytica .
Y1  - 1990///
CY  - Boca Raton, Florida; USA
PB  - CRC Press Inc.
SN  - 0849353424
AD  - Diamond, L. S.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19900867284.  Publication Type: Book chapter.  Language: English.  Number of References: 45 ref. Subject Subsets: Protozoology
N2  - The historic technological developments in the cultivation of E. histolytica are reviewed in 3 sections: xenic, monoxenic and axenic culture, followed by a brief discussion of unsolved problems in its cultivation.
KW  - culture techniques
KW  - history
KW  - Human diseases
KW  - parasites
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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ER  - 

TY  - GEN
T1  - Ehrlichiosis. A vector-borne disease of animals and humans.
A2  - Williams, J. C.
A2  - Kakoma, I.
T2  - Ehrlichiosis. A vector-borne disease of animals and humans.
Y1  - 1990///
CY  - 3300 AA Dordrecht: Kluwer Academic Publishers; Netherlands
SN  - 0792306910
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19902207201.  Publication Type: Conference proceedings; Book.  Language: English.  Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - The 12 papers in this book are based on a conference held in Washington, DC in December 1988, subsequently updated to incorporate research findings obtained in 1989. The chapters are: historical background and global importance of ehrlichiosis; in vitro cultivation of ehrlichiae; ultrastucture of rickettsiae with particular reference to ehrlichiae; antigenic properties of ehrlichiae and other rickettsiae; biological properties of the genus Ehrlichia; biological and pathogenic properties of E. risticii; pathophysiology of canine ehrlichiosis; experimental ehrlichiosis in nonhuman primates; human ehrlichiosis in the USA; evolutionary history of chlamydiae; recent research on cowdriosis; current research strategies on ehrlichiosis.
KW  - bacterial diseases
KW  - dog diseases
KW  - horse diseases
KW  - Zoonoses
KW  - Dogs
KW  - Ehrlichia
KW  - Ehrlichia canis
KW  - horses
KW  - Neorickettsia risticii
KW  - Rickettsiales
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Anaplasmataceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Ehrlichia
KW  - Equus
KW  - Equidae
KW  - Perissodactyla
KW  - Neorickettsia
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - Ehrlichia risticii
KW  - zoonotic infections
KW  - Animal Health and Hygiene (General) (LL800) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pets and Companion Animals (LL070) 
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ER  - 

TY  - GEN
T1  - Immune responses in human hookworm infection.
AU  - Ottesen, E. A.
A2  - Schad, G. A.
A2  - Warren, K. S.
T2  - Hookworm disease - current status and new directions.
Y1  - 1990///
CY  - London; UK
PB  - Taylor & Francis Ltd.
SN  - 0850667623
AD  - Ottesen, E. A.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Building 10, Rm 11C108, Bethesda, MD 20215, USA.
N1  - Accession Number: 19920878974.  Publication Type: Book chapter.  Language: English.  Number of References: 32 ref. Subject Subsets: Helminthology
N2  - An overview of the immune responses in human hookworm infection is given. The information is presented in 2 main sections: human immune responses to hookworms observed after experimental infections in volunteers; functional implications of the immune responses observed in human hookworm infection.
KW  - Eosinophils
KW  - helminths
KW  - Hookworms
KW  - Human diseases
KW  - immune response
KW  - Immunology
KW  - Lymphocytes
KW  - parasites
KW  - Ancylostomatidae
KW  - man
KW  - Nematoda
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - eosinophil leukocytes
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Molecular biology of Plasmodium.
AU  - McCutchan, T. F.
A2  - Wyler, D. J.
T2  - Modern parasite biology: cellular, immunological, and molecular aspects.
Y1  - 1990///
CY  - New York; USA
PB  - W. H. Freeman and Company
SN  - 0716720388\0716721406
AD  - McCutchan, T. F.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910882447.  Publication Type: Book chapter.  Language: English.  Number of References: 5 ref. Subject Subsets: Protozoology
N2  - This chapter discusses the role of molecular biology in the efforts to understand and eradicate malaria, and emphasizes molecular biology relating to diagnosis, taxonomy, genetics, gene analysis and vaccine production.
KW  - biology
KW  - biotechnology
KW  - malaria
KW  - molecular genetics
KW  - parasites
KW  - vaccines
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - GEN
T1  - Visceral larva migrans and other unusual helminth infections.
AU  - Nash, T. E.
A2  - Mandell, G. L.
A2  - Douglas, R. G., Jr.
A2  - Bennett, J. E.
T2  - Principles and practice of infectious diseases.
Y1  - 1990///
CY  - New York; USA
PB  - Churchill Livingstone Inc.
SN  - 0443086869
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910871840.  Publication Type: Book chapter.  Language: English.  Number of References: 40 ref. Subject Subsets: Helminthology
N2  - Unusual helminth infections of man are discussed in this chapter with reference to the clinical significance of eosinophilia. The prevalence, clinical manifestations, diagnosis, treatment, management, and prevention of visceral larva migrans (toxocariasis) and anisakiasis are considered. Cutaneous larval migrans (creeping eruption), eosinophilic meningitis, abdominal angiostrongyliasis, dirofilariasis, capillariasis, and swimmer's itch are the other conditions included.
KW  - Developmental stages
KW  - helminths
KW  - Human diseases
KW  - infectious diseases
KW  - larva migrans
KW  - parasites
KW  - Anisakis
KW  - man
KW  - Nematoda
KW  - Toxocara canis
KW  - Anisakidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Toxocara
KW  - Ascarididae
KW  - Ascaridida
KW  - communicable diseases
KW  - creeping eruption
KW  - general account
KW  - growth phase
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - GEN
T1  - Retrovirus biology and human disease.
A2  - Gallo, R. C.
A2  - Wong-Stall, F.
T2  - Retrovirus biology and human disease.
Y1  - 1990///
CY  - New York, NY 10016; USA
PB  - Marcel Dekker, Inc.
SN  - 082477874X
AD  - National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19902206688.  Publication Type: Book.  Language: English.  Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - The purpose of this book is to describe some of the essential developments, both historical and current, relating to the retroviruses and the diseases they cause. The editors refer in the preface, to the tremendous amount of information on these viruses which has been obtained in the short time since their discovery and their link to disease. The emphasis is on the human T-leukaemia viruses (HTLVs) and the human immunodeficiency viruses (HIVs), but the book contains several chapters on animal retroviruses: feline leukaemia virus because it was the first transmissible, pathogenic leukaemia virus identified in nature; bovine leukaemia virus because of its many parallels and actual relationship to the HTLV; and the animal lentiviruses because of their relatonship to the HIVs. These papers are in the form of reviews, and it is possible that they have duplicated other reviews. However, it will serve a useful purpose in bringing all this information together. A quick scan revealed some printing errors and there seem to be a limited number of 1989 citations in the lists of references to these papers about the animal viruses. There is a short subject index.
KW  - bovine leukemia virus
KW  - Caprine arthritis encephalitis virus
KW  - Cats
KW  - Feline immunodeficiency virus
KW  - Gammaretrovirus
KW  - Lentivirus
KW  - Retroviridae
KW  - Visna/maedi virus
KW  - Deltaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - bovine leukaemia virus
KW  - Bovine oncovirus
KW  - Feline oncovirus
KW  - Lentivirinae
KW  - Visna maedi virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Animal Health and Hygiene (General) (LL800) 
KW  - Pets and Companion Animals (LL070) 
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ER  - 

TY  - JOUR
T1  - Randomized clinical trials of weight reduction in nonhypertensive persons.
AU  - Cutler, J. A.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1991///
VL  - 1
IS  - 4
SP  - 363
EP  - 370
SN  - 1047-2797
AD  - Cutler, J. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931458804.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
N2  - A review. Since 1987, 4 randomized, controlled clinical trials in the USA with 872 non-hypertensive subjects have produced results on weight-reducing interventions, involving decreased energy intake and/or increased energy expenditure, for effects on blood pressure (BP). The Hypertension Prevention Trial maintained a 3.5-kg net weight loss through 36 months with intake reduction alone. This programme decreased BP by 2.4/1.8 mm Hg (systolic/diastolic) compared with controls, but both weight loss and blood pressure changes were smaller when combined with decreased sodium intake. A Stanford University trial achieved weight losses of 7.4 and 5.1 kg over 12 months with diet and exercise, respectively. Effects on clinic BP were in the range of 1.5 to 3.0 mm Hg, and did not differ by intervention approach. The sole trial in children, conducted at the University of Michigan, found similar weight loss (about 7 kg) and BP effects from limiting energy intake over 20 weeks, regardless of inclusion of an exercise programme; the latter did, however, result in greater reductions in percentage body fat, heart rate and serum insulin level. The Primary Prevention of Hypertension trial tested a multifactor intervention, including reductions in weight (mean, 2.7 kg), sodium and alcohol intake, and increased physical activity. During a 5-year period, clinic BP was reduced by 2.0/1.9 mm Hg, and the incidence of hypertension by 52%. It is concluded that weight loss, however achieved, lowers BP in overweight, non-hypertensive persons, and probably can contribute substantially to reducing the incidence of hypertension. Whether there are independent effects additive to weight loss from increasing physical activity and reducing sodium intake remains unknown.
KW  - blood pressure
KW  - Obesity
KW  - reviews
KW  - weight reduction
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Workshop on obesity and blood pressure
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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ER  - 

TY  - JOUR
T1  - Diet and the risk of in situ cervical cancer among white women in the United States.
AU  - Ziegler, R. G.
AU  - Jones, C. J.
AU  - Brinton, L. A.
AU  - Norman, S A.
AU  - Mallin, K.
AU  - Levine, R. S.
AU  - Lehman, H. F.
AU  - Hamman, R. F.
AU  - Trumble, A. C.
AU  - Rosenthal, J. F.
AU  - Hoover, R. N.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1991///
VL  - 2
IS  - 1
SP  - 17
EP  - 29
SN  - 0957-5243
AD  - Ziegler, R. G.: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19921446058.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 50-81-7, 59-30-3, 68-26-8.  Subject Subsets: Human Nutrition
N2  - A case-control study of women with incident in situ and invasive cervical cancer was conducted during 1982-83 in 4 US areas reporting to the Comprehensive Cancer Patient Data System: Birmingham, Alabama; Chicago, Illinois; Denver, Colorado; Miami, Florida; and Philadelphia, Pennsylvania. Controls were selected by random-digit telephone dialing, and matched to invasive cases on age, race and telephone exchange. Of the white non-Hispanic in situ cases and controls identified, 229 (78%) and 502 (74%) were successfully interviewed. Diet was assessed by asking about the usual adult frequency of consumption of 75 food items and the use of vitamin supplements. Included were the major sources of the 4 micronutrients postulated to reduce the risk of cervical cancer: carotenoids, vitamin A, vitamin C and folate. Weak inverse associations between risk of in situ disease and intake of carotenoids, vitamin C, folate, fruit and vegetables/fruits were noted but, with further analysis, these seemed attributable to residual confounding by the multiple lifestyle-related risk factors for this disease and possibly to selection bias. Vitamin A and vegetable intake were unrelated to risk. Dark yellow-orange vegetable consumption and duration of multivitamin use were each strongly related to reduced risk of in situ disease (P for trend = 0.02 and 0.002, respectively). The absence of persuasive protect effects for the 4 micronutrients, and the similar findings from the analysis of invasive cervical cancer, do not concur with other epidemiologic studies, and suggest that the role of diet and nutrition in the aetiology of cervical cancer is not yet resolved.
KW  - ascorbic acid
KW  - Carcinoma
KW  - carotenoids
KW  - cervix
KW  - folic acid
KW  - fruit
KW  - intake
KW  - retinol
KW  - vegetables
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - folacin
KW  - folate
KW  - tetraterpenoids
KW  - United States of America
KW  - vegetable crops
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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TY  - JOUR
T1  - Laboratory confirmation of Lyme disease.
AU  - Schwan, T. G.
AU  - Simpson, W. J.
AU  - Rosa, P. A.
JO  - Canadian Journal of Infectious Diseases
JF  - Canadian Journal of Infectious Diseases
Y1  - 1991///
VL  - 2
IS  - 2
SP  - 64
EP  - 69
SN  - 1180-2332
AD  - Schwan, T. G.: Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19920510378.  Publication Type: Journal Article; Conference paper.  Language: English.  Language of Summary: French.  Number of References: 56 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Lyme disease can be confirmed in the laboratory by isolation or detection of Borrelia burgdorferi, or by detecting a diagnostic change in the titre of antibodies specific to the spirochaete. B. burgdorferi can be isolated and cultivated in Barbour-Stoenner-Kelly II medium. It can be detected by light microscopy in tissue sections or, rarely, in blood smears using various staining methods. There is interest in the development of alternative detection methods, including identification of specific antigens of B. burgdorferi in the urine of suspected cases and demonstration of the presence of species-specific DNA using polymerase chain reaction assays. Currently, serological tests (indirect immunofluorescence assay, ELISA and Western immunoblot) are the most practical and available methods for confirming Lyme disease.
KW  - Antibodies
KW  - Antigens
KW  - Detection
KW  - diagnosis
KW  - ELISA
KW  - Human diseases
KW  - Immunoblotting
KW  - Immunofluorescence
KW  - Lyme disease
KW  - Borrelia burgdorferi
KW  - man
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - bacterium
KW  - enzyme linked immunosorbent assay
KW  - fluorescent antibody technique
KW  - IFAT
KW  - immunogens
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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ER  - 

TY  - JOUR
T1  - Mouse models of human diseases.
AU  - Westphal, H.
JO  - Current Opinion in Biotechnology
JF  - Current Opinion in Biotechnology
Y1  - 1991///
VL  - 2
IS  - 6
SP  - 830
EP  - 833
SN  - 0958-1669
AD  - Westphal, H.: Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920195589.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Agricultural Biotechnology
N2  - The use of transgenic mice as models for human diseases such as cancer, Alzheimer's disease and poliomyelitis is described.
KW  - animal models
KW  - Biotechnology
KW  - Human diseases
KW  - transgenics
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920195589&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Blastocystis hominis - past and future.
AU  - Zierdt, C. H.
JO  - Clinical Microbiology Reviews
JF  - Clinical Microbiology Reviews
Y1  - 1991///
VL  - 4
IS  - 1
SP  - 61
EP  - 79
SN  - 0893-8512
AD  - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920884507.  Publication Type: Journal Article.  Language: English.  Number of References: 95 ref. Subject Subsets: Protozoology; Public Health
N2  - A review of B. hominis is provided. Major headings include: history; taxonomy; morphology; mitochondria; division in B. hominis; diagnosis; culture; surveys of intestinal parasites including B. hominis; clinical blastocystosis; effect of disease on large bowel mucosa; treatment.
KW  - human diseases
KW  - parasites
KW  - reviews
KW  - Blastocystis hominis
KW  - man
KW  - protozoa
KW  - Blastocystis
KW  - Amoebida incertae sedis
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - blastocystosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920884507&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmaniasis vector potential of Lutzomyia spp. in Colombian coffee plantations.
AU  - Warburg, A.
AU  - Montoya-Lerma, J.
AU  - Jaramillo, C.
AU  - Cruz-Ruiz, A. L.
AU  - Ostrovska, K.
JO  - Medical and Veterinary Entomology
JF  - Medical and Veterinary Entomology
Y1  - 1991///
VL  - 5
IS  - 1
SP  - 9
EP  - 16
SN  - 0269-283X
AD  - Warburg, A.: A. Warburg, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910504548.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2  - Potential vectors of Leishmania braziliensis were assessed at 4 study sites in the mountainous Valle del Cauca, western Colombia, from March to June 1989. In an active focus of transmission at 1450 m altitude, a coffee plantation at Versalles, there were high densities of anthropophilic phlebotomines: Lutzomyia columbiana and L. townsendi, both in the L. verrucarum species group, and of L. pia. At a comparable altitude in a forest reserve at Yotoco where leishmaniasis is unknown, L. pia was the prevalent species and L. townsendi was absent. In 2 localities at 1150 m altitude, there were plentiful L. lichyi plus both species in the L. verrucarum group, but L. pia was absent. One of these localities, a coffee plantation at Villa Hermosa where a leishmaniasis outbreak occurred in 1986, was compared with a leishmaniasis-free, partly wooded nature reserve at Mateguadua. No natural infections of Leishmania were found in a total of 1896 wild-caught female phlebotomines belonging to at least 7 species. It remains unclear why leishmaniasis transmission is associated with coffee plantations in this part of Colombia. Laboratory-bred females were invariably autogenous, and blood-seeking females of this species were always parous. Parity rates in wild-caught females of other species were 55% Lutzomyia pia, 24% L. columbiana and 14% L. townsendi. Female Lutzomyia infected artificially with Leishmania braziliensis promastigotes developed peripylarian infections. Higher proportions of Lutzomyia townsendi (96%) and L. columbiana (78%) became infected but these species developed lower rates of stomodaeal infections (P &lt; 0.1) than L. lichyi (37%) or L. pia (44%). Only 33% of a Colombian strain of L. longipalpis became infected. Combined evidence, from these laboratory and field studies, indicates that the sandfly species most strongly associated with leishmaniasis transmission in Colombian coffee plantations are L. columbiana and L. townsendi. Further work is required to clarify the local status of the other potential vector phlebotomines.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Phlebotomine sandflies were collected on human bait from March to June 1989 at 4 sites in the Valle del Cauca region of western Colombia. Two sites were coffee plantations, where cases of cutaneous leishmaniasis caused by Leishmania braziliensis Viannia had occurred, and 2 were nature reserves. Eight Lutzomyia spp. were represented in the collections. The highest landing densities (78.9/man-h) were recorded at Versalles plantation (1450 m altitude), with Lutzomyia colombiana (Ritorcelli & Van Ty), Lu. townsendi (Ortiz) and Lu. pia (Fairchild & Hertig) predominant. In Yotoco forest reserve (1550 m), densities were much lower and Lu. pia predominated. At the Villa-Hermosa plantation (1150 m) and the Mateguadua reserve (1150 m, grassland and bush), densities were low and the predominant species was Lu. lichyi (Floch & Abonnenc), with a few Lu. colombiana and Lu. townsendi. Laboratory-bred Lu. lichyi were always autogenous in their first gonotrophic cycle, and all females caught at bait were parous. Parity rates of wild-caught females of other species were 24% for Lu. colombiana, 14% for Lu. townsendi and 55% for Lu. pia. No natural infections with Leishmania were found in 1896 females examined, but when wild-caught females were fed on cultured Le. braziliensis promastigotes, 25% of the Lu. colombiana, 26% of the Lu. townsendi, 37% of the Lu. lichyi and 44% of the Lu. pia developed stomadaeal infections; almost all of them developed pyloric infections. The vectors in the coffee plantations were probably Lu. colombiana and Lu. townsendi, but further work is needed to confirm this.J.E. Hudson
KW  - Autogeny
KW  - coffee
KW  - disease transmission
KW  - disease vectors
KW  - Ecology
KW  - epidemiology
KW  - Forests
KW  - habitats
KW  - infection
KW  - leishmaniasis
KW  - parasites
KW  - Parous rates
KW  - plantations
KW  - transmission
KW  - Vector competence
KW  - vectors
KW  - Colombia
KW  - South America
KW  - Coffea
KW  - Diptera
KW  - Leishmania braziliensis
KW  - Lutzomyia
KW  - Lutzomyia columbiana
KW  - Lutzomyia lichyi
KW  - Lutzomyia longipalpis
KW  - Lutzomyia pia
KW  - Lutzomyia townsendi
KW  - man
KW  - Phlebotominae
KW  - protozoa
KW  - Psychodidae
KW  - Sarcomastigophora
KW  - Rubiaceae
KW  - Rubiales
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Lutzomyia
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - America (South)
KW  - coffee plantations
KW  - leishmaniosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504548&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary fiber and cancer prevention.
AU  - Shankar, S.
AU  - Lanza, E.
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
Y1  - 1991///
VL  - 5
IS  - 1
SP  - 25
EP  - 41
SN  - 0889-8588
AD  - Shankar, S.: National Cancer Institute, The National Institutes of Health, 9000 Rockville Pike, Executive Plaza North, Room 212, Bethesda, MD 20892 6130, USA.
N1  - Accession Number: 19921440269.  Publication Type: Journal Article.  Language: English.  Number of References: 126 ref. Subject Subsets: Human Nutrition
N2  - Epidemiologic, laboratory, and clinical metabolic research suggest that cancer risk can be reduced by a high intake of fibre-containing foods. Although there have been numerous reviews on the association between dietary fibre and colon cancer, more recent studies have also suggested an association with other gastrointestinal cancers, as well as cancers of the breast, ovary, and endometrium. Following a definition of fibre and its physiological effects, studies since 1980 for both colon and other cancers are reviewed.
KW  - Carcinoma
KW  - fibre
KW  - intake
KW  - prevention
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fiber
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antioxidant micronutrients in cancer prevention.
AU  - Dorgan, J. F.
AU  - Schatzkin, A.
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
Y1  - 1991///
VL  - 5
IS  - 1
SP  - 43
EP  - 68
SN  - 0889-8588
AD  - Dorgan, J. F.: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921440270.  Publication Type: Journal Article.  Language: English.  Number of References: 209 ref. Subject Subsets: Human Nutrition
N2  - A protective role for antioxidant micronutrients against cancer has been proposed on theoretical and experimental grounds. The antioxidant micronutrients carotenoids, vitamin C, vitamin E and selenium and their relation to cancer risk, are discussed. For each micronutrient, results of selected animal studies are briefly summarized, although a more comprehensive summary of results of studies in man is provided.
KW  - antioxidants
KW  - Carcinoma
KW  - prevention
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mechanisms of cancer cachexia.
AU  - Langstein, H. N.
AU  - Norton, J. A.
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
Y1  - 1991///
VL  - 5
IS  - 1
SP  - 103
EP  - 123
SN  - 0889-8588
AD  - Langstein, H. N.: J. A. Norton, Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921440273.  Publication Type: Journal Article.  Language: English.  Number of References: 107 ref. Subject Subsets: Human Nutrition
N2  - The precise mechanism by which a cancer patient develops anorexia and progressive wasting, leading to body compositional changes associated with severe malnutrition remains largely unknown. The pathophysiology and the predominant changes in cancer patients and prevailing theories of the causes and mechanisms of these changes are discussed.
KW  - cachexia
KW  - Carcinoma
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440273&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmaniasis in a domestic goat in Kenya.
AU  - Williams, A. O.
AU  - Mutinga, J.
AU  - Rodgers, M.
JO  - Molecular and Cellular Probes
JF  - Molecular and Cellular Probes
Y1  - 1991///
VL  - 5
IS  - 5
SP  - 319
EP  - 325
SN  - 0890-8508
AD  - Williams, A. O.: National Institutes of Health, Fogarty International Center, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878059.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Veterinary Science; Protozoology; Veterinary Science
N2  - The pathological and electron-microscopic features of the first case of autochthonous leishmaniasis affecting a domestic goat in Kenya are described. Using a short amino-acid sequence common to all the species of Leishmania as primers for kDNA synthesis, the intervening sequence of 120 bases was amplified in the goat's tissues by polymerase chain reaction. The Leishmania kinetoplast DNA sequence was detected in all the different infected tissues. The sensitivity and specificity of this assay are discussed. The result of the assay used was consistent with the parasite being either L. major or L. aethiopica as the infecting agent. The isoenzyme studies were consistent with L. aethiopica as the strain responsible for this goat's infection.
KW  - Biotechnology
KW  - Case reports
KW  - DNA amplification
KW  - Leishmaniasis
KW  - Livestock
KW  - parasites
KW  - polymerase chain reaction
KW  - Protozoal infections
KW  - Techniques
KW  - Africa
KW  - Kenya
KW  - Bovidae
KW  - goats
KW  - Leishmania
KW  - protozoa
KW  - Ruminants
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Capra
KW  - Bovidae
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - East Africa
KW  - Africa South of Sahara
KW  - leishmaniosis
KW  - PCR
KW  - protozoal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of the immune response in lymphatic filariasis and onchocerciasis.
AU  - King, C. L.
AU  - Nutman, T. B.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1991///
VL  - 7
IS  - 3
SP  - A54
EP  - A58
AD  - King, C. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872996.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology
N2  - The roles of IL-4, IL-5 and γ-interferon in the induction of the immediate hypersensitivity response in human filarial infection are discussed with regard to: IgE responses; eosinophil responses; allergic responses; immunological tolerance to parasite antigens; the use of defined antigens to study parasite-specific immune responses; the effect of anti-parasite treatment on the immune response.
KW  - Cytokines
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - interferon
KW  - interleukin 4
KW  - interleukin 5
KW  - parasites
KW  - Brugia malayi
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - Wuchereria
KW  - immunity reactions
KW  - immunological reactions
KW  - Immunoparasitology
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular genetics of drug resistance in Plasmodium falciparum malaria.
AU  - Wellems, T. E.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1991///
VL  - 7
IS  - 5
SP  - 110
EP  - 112
AD  - Wellems, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910875246.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 516-21-2, 58-14-0.  Subject Subsets: Protozoology; Tropical Diseases
N2  - The molecular basis of pyrimethamine and cycloguanil resistance in P. falciparum is described and genetic evidence that links chloroquine resistance to a single genetic locus in P. falciparum is reviewed.
KW  - Antimalarials
KW  - Antiprotozoal agents
KW  - chloroquine
KW  - cycloguanil
KW  - drug resistance
KW  - Molecular genetics
KW  - parasites
KW  - pyrimethamine
KW  - resistance
KW  - Resistance mechanisms
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - cycloguanil embonate
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875246&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Critical stages in the development of Plasmodium in mosquitoes.
AU  - Warburg, A.
AU  - Miller, L. H.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1991///
VL  - 7
IS  - 7
SP  - 179
EP  - 181
AD  - Warburg, A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910875273.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The fact that mammalian malarias are transmitted by anopheline mosquitoes, and avian malarias by culicine mosquitoes is examined with regard to current knowledge of development in the midgut; passage through the midgut epithelium, development in the haemocoel, and invasion of the salivary glands. Some documented cases of incompatible mosquito-Plasmodium combinations are cited.
KW  - development
KW  - disease vectors
KW  - Host parasite relationships
KW  - parasites
KW  - Vectors
KW  - Aedes
KW  - Anopheles
KW  - Apicomplexa
KW  - Culex
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - mosquitoes
KW  - parasite host relationships
KW  - Aquatic Biology and Ecology (MM300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - trans Activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene.
AU  - Green, J. E.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1991///
VL  - 11
IS  - 9
SP  - 4635
EP  - 4641
SN  - 0270-7306
AD  - Green, J. E.: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19920192788.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Subject Subsets: Agricultural Biotechnology
N2  - Three lines of transgenic mice containing the human T-cell lymphotropic virus type I (HTLV-I) tax gene develop neurofibromas composed of perineural fibroblasts. Tumours and tumour cell lines derived from these mice produce neurite outgrowth from PC-12 cells and nerve growth factor (NGF), as determined by blot analysis and enzyme-linked immunosorbent assay. In this study, in vitro cotransfection studies demonstrated that Tax protein is able to trans-activate the NGF promoter in NIH 3T3 fibroblast cells. The major cis-acting tax-responsive element in the NGF promoter (AGGGTGTGACGA) was shown to have 92% homology with a tax-responsive element contained within the 21-bp repeats of the HTLV-I long terminal repeat. The receptor for NGF was also expressed in the transgenic tumour cells, suggesting that Tax may activate an autocrine mechanisms through the upregulation of NGF.
KW  - Biotechnology
KW  - Central nervous system
KW  - Gene expression
KW  - Growth factors
KW  - HTLV infections
KW  - leukaemia
KW  - Molecular biology
KW  - nerve tissue
KW  - Regulation
KW  - transgenics
KW  - mice
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood cancer
KW  - CNS
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - leucaemia
KW  - leukemia
KW  - Tax
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Overexpression of transforming growth factor-β in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene.
AU  - Kim, S. J.
AU  - Winokur, T. S.
AU  - Lee, H. D.
AU  - Danielpour, D.
AU  - Kim, K. Y.
AU  - Geiser, A. G.
AU  - Chen, L. S.
AU  - Sporn, M. B.
AU  - Roberts, A. B.
AU  - Jay, G.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1991///
VL  - 11
IS  - 10
SP  - 5222
EP  - 5228
SN  - 0270-7306
AD  - Kim, S. J.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920192718.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2  - The expression of the gene for transforming growth factor β1 (TGF-β1) was examined in transgenic mice carrying the tax gene for human T-cell leukaemia virus 1, which encodes a 40 kDa protein that is a potent transactivator of transcription directed by the viral long terminal repeat and of certain cellular genes. It was shown that tumours from these mice and other tissues, such as submaxillary glands and skeletal muscle, which express high levels of tax mRNA, selectively express high levels of TGF-β1 mRNA and protein. Moreover, TGF-β1 significantly stimulated the incorporation of tritiated thymidine into 1 of 3 cell lines derived from neurofibromas of tax-transgenic mice, which suggests that the excessive production of TGF-β1 may play a role in tumorigenesis, and that these mice may serve as a useful model for studying the biological effects of TGF-βin vivo.
KW  - Animal models
KW  - Biotechnology
KW  - gene expression
KW  - Genetic engineering
KW  - Growth factors
KW  - HTLV infections
KW  - leukaemia
KW  - Pathogenesis
KW  - transgenics
KW  - mice
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood cancer
KW  - genetic manipulation
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - leucaemia
KW  - leukemia
KW  - tax
KW  - Transforming growth factor-beta
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920192718&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Empiric therapy with amphotericin B in febrile granulocytopenic patients.
AU  - Walsh, T. J.
AU  - Lee, J.
AU  - Lecciones, J.
AU  - Rubin, M.
AU  - Butler, K.
AU  - Francis, P.
AU  - Weinberger, M.
AU  - Roilides, E.
AU  - Marshall, D.
AU  - Gress, J.
AU  - Pizzo, P. A.
JO  - Reviews of Infectious Diseases
JF  - Reviews of Infectious Diseases
Y1  - 1991///
VL  - 13
IS  - 3
SP  - 496
EP  - 503
AD  - Walsh, T. J.: Section of Infectious Diseases, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911210555.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 49 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - Invasive fungal infection in granulocytopenic patients with neoplastic diseases, historical perspective and rationale for empiric use of amphotericin B, non-randomized and randomized studies of empiric amphotericin B, differential diagnosis, comprehensive approach to febrile granulocytopenic patients, limitations of empiric amphotericin B therapy and alternatives to amphotericin B in persistently febrile granulocytopenic patients are all discussed.
KW  - amphotericin B
KW  - Antifungal agents
KW  - Mycoses
KW  - predisposition
KW  - therapy
KW  - fungistats
KW  - granulocytopenia
KW  - Management of the immunocompromised patient
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210555&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retroviral vector-mediated in vivo expression of low-density-lipoprotein receptors in the Watanabe heritable hyperlipidemic rabbit.
AU  - Dichek, D. A.
AU  - Bratthauer, G. L.
AU  - Beg, Z. H.
AU  - Anderson, K. D.
AU  - Newman, K. D.
AU  - Zwiebel, J. A.
AU  - Hoeg, J. M.
AU  - Anderson, W. F.
JO  - Somatic Cell and Molecular Genetics
JF  - Somatic Cell and Molecular Genetics
Y1  - 1991///
VL  - 17
IS  - 3
SP  - 287
EP  - 301
SN  - 0740-7750
AD  - Dichek, D. A.: Molecular Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920196516.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Agricultural Biotechnology; Human Nutrition
N2  - In this study, in vivo expression of recombinant low-density-lipoprotein (LDL) receptors was demonstrated in the Watanabe heritable hyperlipidaemic (WHHL) rabbit. A retroviral vector was constructed containing the human LDL receptor cDNA and was used to transduce primary skin fibroblasts from WHHL rabbits. The integrity and function of the introduced LDL receptor was established by immunoprecipitation, by a fluorescent LDL binding assay and by the ability of the transduced cells to suppress 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity in response to exogenous cholesterol. Autologous transduced fibroblasts were reimplanted into rabbit. In vivo LDL receptor expression and the survival of the transduced cells were analysed by immunohistochemistry and by LDL binding assay performed on cells recovered from the implants. LDL receptor-bearing cells could be identified on tissue sections and recovered from implants for up to 4 weeks. Total and LDL cholesterol levels decreased significantly after implantation of the transduced cells; however, control experiments indicated that the decreases were not mediated through the recombinant LDL receptor. While in vivo stable expression of recombinant LDL receptors in Watanabe rabbits is possible, consequent changes in lipid levels must be interpreted with caution. This system of site-specific in vivo expression of recombinant LDL receptors permits further evaluation of the role of LDL receptor-gene replacement in the therapy of hypercholesterolaemia.
KW  - animal models
KW  - Biotechnology
KW  - fibroblasts
KW  - Gene therapy
KW  - gene transfer
KW  - Hypercholesterolaemia
KW  - Hyperlipaemia
KW  - low density lipoprotein
KW  - receptors
KW  - retroviral vectors
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - hyperlipemia
KW  - in vivo
KW  - Low density lipoproteins
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920196516&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemistry of venom alkaloids in the ant genus Megalomyrmex.
AU  - Jones, T. H.
AU  - Blum, M. S.
AU  - Fales, H. M.
AU  - Brandão, C. R. F.
AU  - Lattke, J.
JO  - Journal of Chemical Ecology
JF  - Journal of Chemical Ecology
Y1  - 1991///
VL  - 17
IS  - 9
SP  - 1897
EP  - 1908
SN  - 0098-0331
AD  - Jones, T. H.: Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930517627.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Chemical analyses of 3 species in the Neotropical ant genus Megalomyrmex have identified this taxon as the 3rd myrmicine genus to produce alkaloids as major venom products. Workers of M. leoninus and workers and ergatoids of M. goeldii produce one or more of 4 trans-2,5-dialkylpyrrolidines previously identified in other myrmicine genera. M. modestus, on the other hand, is distinctive in producing the novel alkaloid (5E, 8E)-3-butyl-5-hexylpyrrolizidine, whose structure was established using a micro-Hofmann degradation sequence. The relationship of Megalomyrmex to other alkaloid-producing ant genera is discussed along with the possible chemotaxonomic significance of the analysed species when viewed in terms of the recognized species groups in this genus.
KW  - Alkaloids
KW  - Biochemistry
KW  - characterization
KW  - Chemotaxonomy
KW  - Toxins
KW  - venoms
KW  - Brazil
KW  - Venezuela
KW  - Formicidae
KW  - Hymenoptera
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Formicidae
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Andean Group
KW  - biochemical taxonomy
KW  - Megalomyrmex
KW  - Megalomyrmex goeldii
KW  - Megalomyrmex leoninus
KW  - Megalomyrmex modestus
KW  - Toxinology
KW  - venom
KW  - Plant Composition (FF040) 
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517627&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemistry of venom alkaloids in the ant Megalomyrmex foreli (Myrmicinae) from Costa Rica.
AU  - Jones, T. H.
AU  - DeVries, P. J.
AU  - Escoubas, P.
JO  - Journal of Chemical Ecology
JF  - Journal of Chemical Ecology
Y1  - 1991///
VL  - 17
IS  - 12
SP  - 2507
EP  - 2518
SN  - 0098-0331
AD  - Jones, T. H.: Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930517531.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Chemical analysis of the venom of M. foreli from Cost Rica revealed the presence of 4 major alkaloidal components. 2 of these, 2-butyl-5-(E,1-heptenyl)-5-pyrroline and 2-butyl-5-(E,E,1,3-heptadienyl)-5-pyrroline, constitute a new functional class of ant venom alkaloids, whose structures were assigned from their spectral and chemical behaviour and unambiguous syntheses. The function of these compounds is suggested by field observations of the behaviour of M. foreli, its sting morphology and the relative toxicity of these 2 compounds against termite (Reticulitermes speratus) workers.
KW  - Alkaloids
KW  - Behaviour
KW  - Biochemistry
KW  - characterization
KW  - Morphology
KW  - Social insects
KW  - Sting apparatus
KW  - Toxicity
KW  - venoms
KW  - Central America
KW  - Costa Rica
KW  - Formicidae
KW  - Hymenoptera
KW  - Isoptera
KW  - Reticulitermes speratus
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Reticulitermes
KW  - Rhinotermitidae
KW  - Isoptera
KW  - Formicidae
KW  - America
KW  - CACM
KW  - Central America
KW  - Developing Countries
KW  - Latin America
KW  - Threshold Countries
KW  - behavior
KW  - Megalomyrmex
KW  - Megalomyrmex foreli
KW  - Toxinology
KW  - venom
KW  - Plant Composition (FF040) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517531&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lyme borreliosis: ten years after discovery of the etiologic agent, Borrelia burgdorferi.
AU  - Burgdorfer, W.
JO  - Infection
JF  - Infection
Y1  - 1991///
VL  - 19
IS  - 4
SP  - 257
EP  - 262
SN  - 0300-8126
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950800132.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Since the recovery of its causative agent, B. burgdorferi, in 1981, Lyme borreliosis has become the most prevalent tickborne disease in the USA and Europe. The incidence of reported cases in the USA has increased from 2000 cases in 1987 to over 8000 in 1989. It occurs now in regions where the tick vectors, Ixodes dammini [I. scapularis] and I. pacificus, are absent and where other species of ticks may be responsible for maintaining and distributing the spirochaete. In Europe, Lyme borreliosis has been reported from 19 countries; its occurrence coincides with the distribution of I. ricinus. Specific and dependable serological tests are still not available, but development of probes for specific antigens and the polymerase chain reaction appear promising in detecting ongoing infection and in the identification of B. burgdorferi. Brief mention is made of advances in the development of whole cell and genetically engineered vaccines.
KW  - disease vectors
KW  - human diseases
KW  - immunodiagnosis
KW  - Lyme disease
KW  - reviews
KW  - tickborne diseases
KW  - vaccines
KW  - Europe
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Ixodidae
KW  - man
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Metastigmata
KW  - Acari
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - lyme borreliosis
KW  - serological diagnosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relationships of dietary fat consumption to serum total and low-density lipoprotein cholesterol in Hispanic preschool children.
AU  - Shea, S.
AU  - Basch, C. E.
AU  - Irigoyen, M.
AU  - Zybert, P.
AU  - Rips, J. L.
AU  - Contento, I.
AU  - Gutin, B.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1991///
VL  - 20
IS  - 2
SP  - 237
EP  - 249
SN  - 0091-7435
AD  - Shea, S.: Columbia University from the National Heart, Lung, and Blood Institute, Columbia University, Atchley Pavilion 1310, 161 Fort Washington Avenue, New York, NY 10032, USA.
N1  - Accession Number: 19921443987.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The relation between dietary fat intake and serum lipids in 108 Hispanic children 4 to 5 years old was studied. Four 24-h recalls about 3 months apart and 2 Willett semiquantitative food frequency questionnaires about 6 months apart were obtained by interviewing the children's mothers. Children in the highest tertile of total fat consumption (36.2% of total energy) compared with the lowest tertile (30.2% of total energy) had a mean total serum cholesterol of 4.32 (167) vs. 3.91 mmol/litre (151 mg/100 ml) (test for linear trend across tertiles, P&lt;0.05) and a mean low density lipoprotein cholesterol of 2.74 (106) vs. 2.29 mmol/litre (89 mg/100 ml) (test for linear trend, P&lt;0.01). Children in the highest tertile of saturated fat consumption (14.6% of total energy) compared with the lowest tertile (11.2% of total energy) had a mean total serum cholesterol of 4.39 (170) vs. 3.97 mmol/litre (154 mg/100 ml) (test for linear trend, P&lt;0.05) and a mean low-density lipoprotein cholesterol of 2.80 (108) vs. 2.35 mmol/litre (91 mg/100 ml) (test for linear trend, P&lt;0.01). These relations remained significant when energy-adjusted nutrient intakes were examined and after adjustment in multiple linear regression models for age, sex, and body mass index, with the exception of the association of energy-adjusted total fat with total serum cholesterol (P=0.07). Similar results were obtained using the Willett questionnaires. Dietary fat, particularly saturated fat consumption, is an important correlate of blood lipid values in preschool children. These are the first reported data indicating that the Willett questionnaire, as a method for measuring the atherogenic components of diet, has criterion-related validity in young children.
KW  - blood
KW  - Children
KW  - cholesterol
KW  - ethnic groups
KW  - fats
KW  - intake
KW  - low density lipoprotein
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443987&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Host-parasite relationships of Ascogregarina chagasi (Eugregarinorida, Aseptatorina, Lecudinidae) in Lutzomyia longipalpis (Diptera: Psychodidae).
AU  - Warburg, A.
AU  - Ostrovska, K.
JO  - International Journal for Parasitology
JF  - International Journal for Parasitology
Y1  - 1991///
VL  - 21
IS  - 1
SP  - 91
EP  - 98
SN  - 0020-7519
AD  - Warburg, A.: Medical Entomology Unit, Malaria Section, National Institutes of Health, Building 4, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910871642.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The life cycle of A. chagasi in larvae and in adult female L. longipalpis was studied by light and electron microscopy. Sporozoites and young gamonts were attached to the epithelial lining of the larval midgut via an osmiophilic contact zone. The mucron of young gamonts was bordered by an invaginated pellicular fold, and an electron-opaque vesicular structure was observed adjacent to it. Sporozoites possessed an apical complex and were bound by a double membrane with underlying subpellicular microtubules. The gamont pellicle was uniformly corrugated and consisted of 2 cortical membranes and a plasma membrane. Mature gamonts and gametocysts were found in the posterior ectoperitrophic space of 3rd and 4th instar larval midguts and in the haemocoel of adult flies. Gametocysts in adult females adhered to the genital accessory glands, where they were encased in electron-dense capsules secreted by the fly through haemocyte-mediated humoral immune reactions. Oocytes were spindle-shaped and bound by a double-layered wall with a discernible polar plug at each end. Sporulation was endogenous, occurring within gametocysts in the midguts of larvae or the accessory glands of adult females. FITC-phalloidine staining of all stages of A. chagasi except mature gametocysts produced bright fluorescence, indicating the presence of a diffuse, actin-like protein in the cytoplasm.
KW  - Developmental stages
KW  - disease vectors
KW  - Electron microscopy
KW  - Entomopathogenic protozoa
KW  - entomopathogens
KW  - host parasite relationships
KW  - hosts
KW  - infections
KW  - natural enemies
KW  - parasites
KW  - pathogens
KW  - Vectors
KW  - Apicomplexa
KW  - Diptera
KW  - Lutzomyia longipalpis
KW  - Phlebotominae
KW  - protozoa
KW  - Psychodidae
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - Lutzomyia
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Ascogregarina
KW  - Lecudinidae
KW  - Eugregarinorida
KW  - Ascogregarina chagasi
KW  - growth phase
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Biological Control (HH100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - 1,25-Dihydroxyvitamin D3 receptors and resistance: implications in rickets, osteomalacia, and other conditions.
AU  - Marx, S. J.
A2  - Glorieux, F. H.
JO  - Nestlé Nutrition Workshop Series
JF  - Nestlé Nutrition Workshop Series
Y1  - 1991///
VL  - 21
SP  - 167
EP  - 184
CY  - New York; USA
PB  - Raven Press
SN  - 0742-2806
AD  - Marx, S. J.: Mineral Metabolism Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921450151.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref. Registry Number: 32222-06-3.  Subject Subsets: Human Nutrition
N2  - Defects in calcitriol receptors that disturb responsivity in tissues leading to rickets, osteomalacia and other conditions are reviewed. An overview of the normal structure, normal regulation and normal actions of calcitriol receptors is also given.
KW  - Bone diseases
KW  - calcitriol
KW  - Osteomalacia
KW  - receptors
KW  - reviews
KW  - Rickets
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 1,25-dihydroxycholecalciferol
KW  - 1,25-dihydroxyvitamin D
KW  - disorders
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921450151&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Unusual aspects of allergic bronchopulmonary fungal disease: report of two cases due to Curvularia organisms associated with allergic fungal sinusitis.
AU  - Travis, W. D.
AU  - Kwon-Chung, K. J.
AU  - Kleiner, D. E.
AU  - Geber, A.
AU  - Lawson, W.
AU  - Pass, H. I.
AU  - Henderson, D.
JO  - Human Pathology
JF  - Human Pathology
Y1  - 1991///
VL  - 22
IS  - 12
SP  - 1240
EP  - 1248
SN  - 0046-8177
AD  - Travis, W. D.: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211946.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp. and associated with allergic fungal sinusitis (AFS) are reported. C. lunata [Cochliobolus lunatus] was cultured from a 48-yr-old woman and Curvularia senegalensis from a 16-yr-old boy. Prominent follicular bronchiolitis and xanthomatous bronchiolitis were misleading histological features in the latter case and led to a delay in recognition of the diagnosis. Both patients presented primarily with AFS; ABPFD was detected subsequently. Based on these cases and a review of the literature, unusual clinical and pathological features that can occur in ABPFD are discussed.
KW  - allergies
KW  - hosts
KW  - infections
KW  - lungs
KW  - sinuses
KW  - USA
KW  - Cochliobolus lunatus
KW  - man
KW  - Pleosporaceae
KW  - Cochliobolus
KW  - Pleosporaceae
KW  - Pleosporales
KW  - Dothideomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Curvularia
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Curvularia senegalensis
KW  - fungus
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211946&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma pharmacokinetics and tissue penetration of a novel antifungal triazole, Bay R 3783, and its long-lasting active metabolite, Bay U 3625, in rabbits.
AU  - Lee, J. W.
AU  - Ritter, W.
AU  - Lecciones, J.
AU  - Kelly, P.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Antimicrobial Chemotherapy
JF  - Journal of Antimicrobial Chemotherapy
Y1  - 1991///
VL  - 27
IS  - 6
SP  - 837
EP  - 844
SN  - 0305-7453
AD  - Lee, J. W.: Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19911210535.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The plasma pharmacokinetics and tissue penetration of Bay R 3783 (BR), a new antifungal triazole, and one of its active metabolites, Bay U 3625 (BU), were studied in rabbits. Plasma levels of BR and BU were determined simultaneously in 5 rabbits for 6 d after a single oral dose of 20 or 40 mg/kg BR. For BR, the mean Cmax was 1.9±0.4 mg/litre, Tmax 2.0±0.7 h, AUC∞ 7.5±1.6 mg per h/litre and terminal plasma T1/2 2.1±0.1 h. For BU, the mean Cmax was 0.84±0.09 mg/litre, Tmax 24±4 h, the AUC∞ 61.9±6.5 mg per h/litre and the plasma T1/2 was 48±3 h. In a multi-dose study, the plasma BR clearance during wash-out gradually diminished, indicating possible metabolite inhibition of BRs biotransformation. No hepatic or renal toxicity was seen after 28 d of dosing with BR 40 mg/kg per d. Both BR and BU penetrated well into tissues, with tissue drug concn over 3 times higher than in plasma at multiple tissue sites. Persistence of BU in plasma, however, resulted in prolonged, higher tissue levels of BU than of BR. It is concluded that BR is converted to a long-lasting active metabolite BU, that persistence of BU in tissue is prolonged and that these properties may permit BU to contribute significantly to the antifungal activity of BR.
KW  - Antifungal agents
KW  - pharmacokinetics
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Bay R 3783
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210535&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transport of fatty acids and monoacylglycerols in white and brown adipose tissues.
AU  - Scow, R. O.
AU  - Blanchette-Mackie, E. J.
JO  - Brain Research Bulletin
JF  - Brain Research Bulletin
Y1  - 1991///
VL  - 27
IS  - 3/4
SP  - 487
EP  - 491
SN  - 0361-9230
AD  - Scow, R. O.: National Institutes of Health, Building 6, Room 137, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931461187.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Human Nutrition
N2  - The manner in which fatty acids and monacylglycerols are transported in white and brown adipose tissues is the subject of this review.
KW  - Adipose tissue
KW  - fatty acids
KW  - monoacylglycerols
KW  - reviews
KW  - transport
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - monoglycerides
KW  - transportation
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931461187&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of a restriction fragment length polymorphism (RFLP) as a genetic marker in crosses of Anopheles gambiae (Diptera: Culicidae): independent assortment of a diphenol oxidase RFLP and an esterase locus.
AU  - Romans, P.
AU  - Seeley, D. C.
AU  - Kew, Y.
AU  - Gwadz, R. W.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1991///
VL  - 28
IS  - 1
SP  - 147
EP  - 151
SN  - 0022-2585
AD  - Romans, P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910505292.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Analysis of restriction fragment length polymorphism (RFLP) is a powerful tool for analysing linkage relationships in species where few genetic markers have been described and where conduct of crosses is difficult. It also permits integration of genetic and physical (cytogenetic) data when the probes have been mapped by in situ hybridization. To illustrate the utility of the method, and because some mutations of a diphenol oxidase gene might conceivably produce the malaria refractoriness phenotype of ookinete-oocyst encapsulation, backcrosses between 2 inbred lines of A. gambiae were carried out to determine the linkage relationship between the diphenol oxidase A2 (Dox) gene and the esterase locus associated with refractoriness to Plasmodium cynomolgi NIH. The Dox alleles were a Sal I RFLP visualized by probing Southern blotted DNA from portions of individual mosquitoes with a cloned Dox gene probe. The 2 genes were shown to segregate independently.
KW  - disease vectors
KW  - DNA probes
KW  - Enzymes
KW  - Genes
KW  - genetic markers
KW  - genetics
KW  - Human diseases
KW  - Linkage
KW  - Molecular genetics
KW  - parasites
KW  - restriction fragment length polymorphism
KW  - susceptibility
KW  - vectors
KW  - Anopheles gambiae
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium cynomolgi
KW  - protozoa
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - mosquitoes
KW  - refractoriness
KW  - RFLP
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910505292&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antibody to a 39-kilodalton Borrelia burgdorferi antigen (P39) as a marker for infection in experimentally and naturally inoculated animals.
AU  - Simpson, W. J.
AU  - Burgdorfer, W.
AU  - Schrumpf, M. E.
AU  - Karstens, R. H.
AU  - Schwan, T. G.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1991///
VL  - 29
IS  - 2
SP  - 236
EP  - 243
SN  - 0095-1137
AD  - Simpson, W. J.: Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19910504929.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia burgdorferi expresses a conserved, species-specific 39-kDa protein (P39) that can stimulate antibodies during human infection. To confirm that anti-P39 antibodies are produced consistently in animals exposed to infectious spirochaetes, white-footed mice (Peromyscus leucopus) and laboratory white mice (Mus musculus, strain BALB/c) were experimentally inoculated with either infectious or non-infectious B. burgdorferi and the antibody response to P39 was determined by immunoblot at 21 days post-inoculation. All mice inoculated with approximately 107 infectious B. burgdorferi produced anti-P39 antibodies and were cultured positive for this spirochaete. Mice inoculated with similar numbers of inactivated or viable non-infectious B. burgdorferi still producing P39 did not induce anti-P39 antibodies. By contrast, putative antiflagellin antibodies were detected in &lt;18% of the infected animals, which supports the notion that antibody reactive with flagellin may not be reliable as a marker for B. burgdorferi exposure as was originally thought. Mice infected with B. burgdorferi following exposure to ticks (Ixodes dammini) produced anti-P39 antibodies no later than 7 days post-infection, indicating that P39 is an effective immunogen in natural infections. Notably, anti-P39 antibodies were the predominant B. burgdorferi reactive antibodies detected early in the infection. Results indicated that anti-P39 antibodies are produced in response to an active infection and are therefore reliable markers for infection in experimentally and naturally inoculated animals.
KW  - antibodies
KW  - disease transmission
KW  - disease vectors
KW  - Immune response
KW  - Immunization
KW  - Immunology
KW  - infection
KW  - Laboratory animals
KW  - Lyme disease
KW  - Tickborne diseases
KW  - transmission
KW  - vectors
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Ixodes scapularis
KW  - Ixodidae
KW  - Mice
KW  - Peromyscus leucopus
KW  - rodents
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Peromyscus
KW  - Sigmodontinae
KW  - bacterium
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - Ixodes dammini
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504929&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rapid method to extract DNA from Cryptococcus neoformans.
AU  - Varma, A.
AU  - Kwon-Chung, K. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1991///
VL  - 29
IS  - 4
SP  - 810
EP  - 812
SN  - 0095-1137
AD  - Varma, A.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19911208798.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - A rapid and easy method for the extraction of total cellular DNA from C. neoformans is described. This procedure modifies and considerably simplifies previously reported methods. Numerous steps were either eliminated or replaced, including preincubations with cell wall permeability agents such as β-mercaptoethanol and dithiothreitol. The commercially available enzyme preparation Novozyme 234 was found to contain a potent concn of DNases which actively degrade DNA. Degradation and loss of DNA was prevented by maintaining a high concn of EDTA in the lysing solution. This procedure resulted in high yields (150-200 µg of DNA from 100 ml of culture) of good-quality (undegraded), high-molecular-weight DNA which was readily digested by restriction endonucleases, making it suitable for use in various molecular applications.
KW  - DNA
KW  - extraction
KW  - genetics
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208798&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dual tracer stable isotopic assessment of calcium absorption and endogenous fecal excretion in low birth weight infants.
AU  - Abrams, S. A.
AU  - Esteban, N. V.
AU  - Vieira, N. E.
AU  - Yergey, A. L.
JO  - Pediatric Research
JF  - Pediatric Research
Y1  - 1991///
VL  - 29
IS  - 6
SP  - 615
EP  - 618
SN  - 0031-3998
AD  - Abrams, S. A.: 9000 Rockville Pike, Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bldg. 10, Rm. 6C-101, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921440067.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 7440-70-2.  Subject Subsets: Human Nutrition
N2  - Using a dual tracer (44Ca orally and 46Ca intravenously) stable isotope technique, true dietary calcium absorption, endogenous faecal Ca excretion, and net Ca retention were measured in 12 low birth weight (1426±260 g) infants fed a high Ca-containing formula. Endogenous faecal Ca excretion averaged 7.2±4.1% of intake, and exceeded 10% of intake in 3 infants. Net Ca retention, 103±38 mg kg-1day,-1 was consistent with previous studies of Ca retention obtained using mass balance techniques and correlated closely (r=0.98, P&lt;0.001) with true Ca absorption but not with endogenous faecal excretion (r=-0.40, P=0.19). Although endogenous faecal excretion may represent a significant source of Ca loss for some low birth weight infants, these data suggest that net Ca retention in low birth weight infants fed a high Ca-containing formula is primarily determined by the total dietary Ca absorbed.
KW  - birth weight
KW  - calcium
KW  - calcium absorption
KW  - excretion
KW  - Infants
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440067&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immune capture and detection of Borrelia burgdorferi antigens in urine, blood, or tissues from infected ticks, mice, dogs, and humans.
AU  - Dorward, D. W.
AU  - Schwan, T. G.
AU  - Garon, C. F.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1991///
VL  - 29
IS  - 6
SP  - 1162
EP  - 1170
SN  - 0095-1137
AD  - Dorward, D. W.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19920511667.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 308067-58-5, 308067-57-4.  Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2  - A rapid and sensitive assay was developed for B. burgdorferi antigens in infected hosts. Polyclonal rabbit antisera were raised against membrane vesciles and an 83-kDa vesicle-associated protein band that was purified from in vitro B. burgdorferi cultures. IgG antibodies were recovered from these sera and tested for a species-specific reaction with several geographically diverse Borrelia isolates by immunoblot analysis. Parlodion-coated electron microscope grids were activated with anti-vesicle F(ab′)2 fragments and then incubated with confirmed or experimental sources of spirochaetal antigens. Such sources included cultured spirochaetes; spirochaete culture supernatants; samples of urine, blood or serum from mice, dogs and humans; triturates of Ixodes ticks; and bladder, spleen, liver, kidney, heart or brain tissues from infected or control mice. Captured antigens were assayed by immune electron microscopy by using anti 83-kDa IgG antibodies and protein A-colloidal gold conjugates. The results indicated that B. burgdorferi appears to shed surface antigens which are readily detectable in urine, blood and several organs from infected hosts. Such antigens were detectable in mouse urine at dilutions exceeding 10-6. Intact spirochaetes were frequently observed on grids incubated with blood, spleen or bladder preparations, and B. burgdorferi was reisolated from the urinary bladders of all experimentally infected mice. These results indicated that B. burgdorferi antigens arise in a variety of host materials. Such antigens can be captured and identified with specific polyclonal antibodies, providing a sensitive assay for monitoring and studying Lyme borreliosis.
KW  - Antibodies
KW  - antigens
KW  - bacterial diseases
KW  - detection
KW  - Diagnostic techniques
KW  - Disease vectors
KW  - Human diseases
KW  - IgG
KW  - immunoassay
KW  - Immunodiagnosis
KW  - Immunoglobulins
KW  - immunology
KW  - Lyme disease
KW  - Tickborne diseases
KW  - California
KW  - Connecticut
KW  - Europe
KW  - France
KW  - Germany
KW  - New York
KW  - North America
KW  - Rhode Island
KW  - USA
KW  - Washington
KW  - Borrelia burgdorferi
KW  - Dogs
KW  - Ixodes scapularis
KW  - Ixodidae
KW  - Man
KW  - Mice
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Muridae
KW  - rodents
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - European Union Countries
KW  - Mediterranean Region
KW  - Western Europe
KW  - Europe
KW  - Middle Atlantic States of USA
KW  - Pacific Northwest States of USA
KW  - antigenicity
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - gamma-globulins
KW  - immune globulins
KW  - immunogens
KW  - Ixodes dammini
KW  - lyme borreliosis
KW  - serological diagnosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pets and Companion Animals (LL070) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511667&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular and immunological analysis of a polymorphic periplasmic protein of Borrelia burgdorferi.
AU  - Simpson, W. J.
AU  - Schrumpf, M. E.
AU  - Hayes, S. F.
AU  - Schwan, T. G.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1991///
VL  - 29
IS  - 9
SP  - 1940
EP  - 1948
SN  - 0095-1137
AD  - Simpson, W. J.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19920511684.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - To assist in the categorization and typing of fresh B. burgdorferi isolates from global foci, a unique species-specific periplasmic protein (P22-A) conserved among all North American and European isolates was identified. The gene encoding this antigen was cloned and the recombinant was used to screen serum collected from experimentally infected animals. Although antibodies were detected in all infected animals at 21 days after inoculation with live, low-passage spirochaetes, the response was stronger in other animals that were inoculated with inactivated and lysed bacteria. This result, along with the immune electron microscopy data, suggests P22-A is concentrated in the periplasmic space. The P22-A antigens exhibited size heterogeneity among different isolates, ranging between 20 and 23 kDa, but as a group the P22-A antigens appeared to retain antigenic homogeneity. Thus, P22-A can serve as a structural marker for characterizing new isolates of B. burgdorferi and may prove useful in future serological assays with a mixture of B. burgdorferi-specific antigens.
KW  - Antigens
KW  - Human diseases
KW  - Lyme disease
KW  - molecular genetics
KW  - proteins
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - immunogens
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511684&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of flaviviruses by reverse-transcriptase polymerase chain reaction.
AU  - Eldadah, Z. A.
AU  - Asher, D. M.
AU  - Godec, M. S.
AU  - Pomeroy, K. L.
AU  - Goldfarb, L. G.
AU  - Feinstone, S. M.
AU  - Levitan, H.
AU  - Gibbs, C. J., Jr.
AU  - Gajdusek, D. C.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1991///
VL  - 33
IS  - 4
SP  - 260
EP  - 267
SN  - 0146-6615
AD  - Eldadah, Z. A.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930517843.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 63231-63-0.  Subject Subsets: Medical & Veterinary Entomology; Public Health; Tropical Diseases
N2  - RNA sequences of 5 flaviviruses were detected by a modified polymerase chain reaction (PCR) that incorporated a reverse transcriptase and RNAase inhibitor. Oligonucleotide primer pairs were synthesized to amplify sequences from St. Louis encephalitis, Japanese encephalitis, yellow fever, dengue 2 and dengue 4 viruses. The amplified products were visualized as bands of appropriate size on ethidium bromide-stained agarose gels. The identity of these products was confirmed by restriction endonuclease cleavage to generate fragments of predicted lengths. The reverse-transcriptase PCR (RT-PCR) successfully amplified flavivirus sequences from cell cultures, frozen brain tissue and formalin-fixed, paraffin-embedded brain tissue. The reactions were highly specific, and the method compared favourably to 2 conventional assays of viral infectivity. RT-PCR followed by PCR with nesting primers was 1000-fold more sensitive in detecting virus than classical infectivity titration by intracerebral inoculation of suckling mice and nearly 1000-fold more sensitive than amplification of virus in cell culture followed by inoculation of mice.
KW  - Arboviruses
KW  - detection
KW  - Diagnosis
KW  - Diagnostic techniques
KW  - polymerase chain reaction
KW  - RNA
KW  - Dengue virus
KW  - Flavivirus
KW  - Japanese encephalitis virus
KW  - St Louis encephalitis virus
KW  - St. Louis encephalitis virus
KW  - Yellow fever virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - PCR
KW  - ribonucleic acid
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517843&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pathogens of phlebotomine sandflies: a review.
AU  - Warburg, A.
AU  - Ostrovska, K.
AU  - Lawyer, P. G.
A2  - Maroli, M.
JO  - Parassitologia (Roma)
JF  - Parassitologia (Roma)
Y1  - 1991///
VL  - 33
IS  - Suppl. 1
SP  - 519
EP  - 526
SN  - 0048-2951
AD  - Warburg, A.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Building 4, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930517068.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Medical & Veterinary Entomology; Biocontrol
N2  - The pathogens of phlebotomine sandflies are reviewed under the headings: viruses; bacteria; protozoa; fungi; nematodes; mites. The potential of these different pathogens as biological control agents of sandflies is briefly discussed.
KW  - Biological control agents
KW  - Entomogenous fungi
KW  - Entomopathogenic bacteria
KW  - Entomopathogenic protozoa
KW  - entomopathogens
KW  - Entomophilic nematodes
KW  - hosts
KW  - Insect viruses
KW  - natural enemies
KW  - pathogens
KW  - reviews
KW  - Acari
KW  - Diptera
KW  - Nematoda
KW  - Phlebotominae
KW  - Psychodidae
KW  - entomopathogens
KW  - animal viruses
KW  - viruses
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - insects
KW  - Hexapoda
KW  - Psychodidae
KW  - Diptera
KW  - biocontrol agents
KW  - biological control organisms
KW  - entomopathogenic fungi
KW  - fungus
KW  - insect nematodes
KW  - viruses of insects
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biological Control (HH100) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517068&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins.
AU  - Cabib, E.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1991///
VL  - 35
IS  - 1
SP  - 170
EP  - 173
SN  - 0066-4804
AD  - Cabib, E.: Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911208077.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 11113-80-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - Polyoxin D, nikkomycin X and nikkomycin Z are all competitive inhibitors of chitin synthetase 2 (Chs2), the essential enzyme for primary septum formation in Saccharomyces cerevisiae, and of Chs1, a repair enzyme. However, Chs2 is more resistant to these antibiotics than Chs1. When Co2+, the best stimulator of Chs2, was used in the assay for this enzyme, the differences in the Kivalues for nikkomycins between the 2 isozymes reached 3 orders of magnitude. These results indicated differences in the active sites of the 2 isozymes. Polyoxin D was much more effective than nikkomycin Z in inhibiting cell growth. The importance of the choice of enzyme and of assay conditions when cell wall-synthesizing enzymes are used in screens for possible antifungal agents is noted.
KW  - antifungal agents
KW  - antifungal properties
KW  - nikkomycins
KW  - pharmacodynamics
KW  - polyoxins
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - anti-fungal properties
KW  - drug action
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - mechanism of drug action
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208077&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography.
AU  - Rex, J. H.
AU  - Hanson, L. H.
AU  - Amantea, M. A.
AU  - Stevens, D. A.
AU  - Bennett, J. E.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1991///
VL  - 35
IS  - 5
SP  - 846
EP  - 850
SN  - 0066-4804
AD  - Rex, J. H.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911209170.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - An improved bioassay for fluconazole using Candida kefyr was developed. This assay is sensitive in the clinically relevant range (2-40 µg/ml) and analyses plasma, serum and cerebrospinal fluid specimens; bioassay results correlate with results obtained by HPLC. Bioassay and HPLC analyses of spiked plasma, serum and cerebrospinal fluid samples (run as unknowns) gave good agreement with expected values. Analysis of specimens from patients gave equivalent results by both HPLC and bioassay. HPLC had a lower within-run coefficient of variation (&lt;2.5% for HPLC vs. &lt;11% for bioassay) and a lower between-run coefficient of variation (&lt;5% vs. &lt;12% for bioassay) and was more sensitive (lower limit of detection, 0.1 µg/ml vs. 2 µg/ml for bioassay). It is concluded that the bioassay is, however, sufficiently accurate and sensitive for clinical specimens, and its relative simplicity, low sample volume requirement, and low equipment cost should make it the technique of choice for analysis of routine clinical specimens.
KW  - antifungal agents
KW  - antifungal properties
KW  - bioassays
KW  - estimation
KW  - Fluconazole
KW  - liquid chromatography
KW  - Candida kefyr
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209170&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis carinii in pleural fluid. The cytologic appearance.
AU  - Elwood, L. J.
AU  - Dobrzanski, D.
AU  - Feuerstein, I. M.
AU  - Solomon, D.
JO  - Acta Cytologica
JF  - Acta Cytologica
Y1  - 1991///
VL  - 35
IS  - 6
SP  - 761
EP  - 764
SN  - 0001-5547
AD  - Elwood, L. J.: Cytopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19920881207.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Protozoology
N2  - The cytological appearance of Pneumocystis carinii in pleural fluid is described. The diagnosis of P. carinii infection was made by examination of air-dried, modified Wright-Giemsa (Diff-Quik)- stained Cytospin preparations of the pleural fluid from a patient with acquired immunodeficiency syndrome. The diagnostic appearances of P. carinii stained by this method and by the Papanicolaou stain are reviewed.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - cytology
KW  - diagnosis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881207&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-β-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.
AU  - Walsh, T. J.
AU  - Lee, J. W.
AU  - Kelly, P.
AU  - Bacher, J.
AU  - Lecciones, J.
AU  - Thomas, V.
AU  - Lyman, C.
AU  - Coleman, D.
AU  - Gordee, R.
AU  - Pizzo, P. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1991///
VL  - 35
IS  - 7
SP  - 1321
EP  - 1328
SN  - 0066-4804
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19911210185.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 79404-91-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - The effects of its linear and nonlinear pharmacokinetics were studied during continuous versus intermittent intravenous infusion of cilofungin in the treatment of experimental disseminated candidosis in persistently granulocytopenic rabbits. Six groups of rabbits were studied, untreated controls (n=32) and 5 cilofungin dosage regimen groups consisting of the following: 25 mg/kg of body wt intravenously twice daily (VLoINT) (n=9); 50 mg/kg twice daily (LoINT) (n=9); 90 mg/kg twice daily (HiINT) (n=11); 5 mg/kg per h for 18 h/d (LoCI) (n=7) and 10 mg/kg per h for 18 h/d (HiCI) (n=7). All regimens achieved plasma concn exceeding the min. inhibitory concn (MIC) for Candida albicans (0.25 µg/ml). In vitro timed kill assays found that the fungicidal activity and rate of kill by cilofungin above the MIC for C. albicans was concn dependent. At the lower dosage regimens (VLoINT, LoINT and LoCI), cilofungin followed linear plasma pharmacokinetics, whereas at higher doses (HiCI and HiINT), nonlinear kinetics consistent with a saturated elimination pathway(s) were observed. Only HiCI and HiINT produced a 10³- to 104-fold reduction in colony forming units/g in candidosis of the brain (P≤0.001). HiCI and HiINT also significantly reduced infection in the choroid (P≤0.05). All regimens, except VLoINT, significantly (P≤0.01) reduced tissue infections in lung, liver, spleen and kidney. However, only the regimens with nonlinear saturation kinetics (HiCI and HiINT) produced a 106 reduction in the spleen and a &gt;105 reduction of C. albicans in the kidney and liver. A simple doubling of the dosage from LoCI to HiCI resulted in tissue concn that were 10 times higher and a 10²- to 104-fold greater antifungal effect. There was a direct correlation (r²=0.83) between tissue concn of cilofungin and antifungal activity. It is concluded that continuous and intermittent infusion dosage regimens that elicit nonlinear saturation plasma pharmacokinetics of cilofungin are associated with increased antifungal activity against experimental disseminated candidosis.
KW  - Antifungal agents
KW  - Cilofungin
KW  - generalized infections
KW  - infections
KW  - pharmacokinetics
KW  - therapy
KW  - Candida albicans
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210185&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of low-dose trimethoprim-sulfamethoxazole thrice weekly for primary and secondary prophylaxis of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients.
AU  - Stein, D. S.
AU  - Stevens, R. C.
AU  - Terry, D.
AU  - Laizure, S. C.
AU  - Palte, S.
AU  - Lancaster, D. J.
AU  - Weems, J. J.
AU  - Williams, C. L.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1991///
VL  - 35
IS  - 9
SP  - 1705
EP  - 1709
SN  - 0066-4804
AD  - Stein, D. S.: Treatment Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, 6003 Executive Boulevard, Room 204-P, Rockville, MD 20852, USA.
N1  - Accession Number: 19920876605.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Protozoology
N2  - An open prospective clinical trial to evaluate the efficacy and toxicity of trimethoprim-sulfamethoxazole given as one double-strength tablet thrice weekly for primary and secondary prophylaxis of P. carinii pneumonia (PCP) to HIV-infected (HIV+) patients from Tennessee, USA, was conducted. A total of 104 HIV+ patients were evaluated, with 74 being in the primary prophylaxis group and 30 being in the secondary prophylaxis group. All except 6 patients received concomitant zidovudine; 5 patients on primary prophylaxis and one patient on secondary prophylaxis refused zidovudine. There were 70 patients evaluated for the efficacy of primary prophylaxis. The mean CD4 count was 124.4±110.1 cells/µl. The mean follow-up time was 11.8±5.8 months (median, 12 months; range, 1 to 32 months). Two non-compliant patients developed PCP after one and 3 months of chemoprophylaxis. The failure rate (under the intention to treat principle) was 2 of 70 patients (2.9%), or one per 413 patient-months of observation. There were 27 patients evaluated for the efficacy of secondary prophylaxis. The mean follow-up time was 12.4±7.2 months (median, 11 months; range, one to 29 months). Two patients, one of whom was noncompliant, were treatment failures, developing PCP after 14 and 15 months of chemoprophylaxis; this gave a failure rate of 2 of 27 patients (7.4%), or one per 167 patient-months of observation. Adverse reactions sufficient to permanently terminate therapy occurred in 9 of 104 patients (8.7%) overall. The serum trimethoprim, sulfamethoxazole, and N4-acetylsulfamethoxazole concentrations measured by HPLC were uniformly low. One double-strength tablet of trimethoprim-sulfamethoxazole taken weekly on Monday, Wednesday, and Friday appeared to be well tolerated and efficacious for the prophylaxis of PCP in HIV+ patients at high risk and deserves further investigation.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Antiprotozoal agents
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - prophylaxis
KW  - North America
KW  - Tennessee
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - East South Central States of USA
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - Trimethoprim sulfamethoxazole
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A serum-free, partly defined medium, PDM-805, for axenic cultivation of Entamoeba histolytica Schaudinn, 1903 and other Entamoeba.
AU  - Diamond, L. S.
AU  - Cunnick, C. C.
JO  - Journal of Protozoology
JF  - Journal of Protozoology
Y1  - 1991///
VL  - 38
IS  - 3
SP  - 211
EP  - 216
AD  - Diamond, L. S.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920874321.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The first serum-free, partly defined medium (PDM-805) for cultivating E. histolytica, E. barreti, E. invadens, and E. terrapinae, is described. PDM-805 was developed by the stepwise replacement of yeast extract, bovine serum, and a casein peptone digest in TYI-S-33, a medium widely used for the axenic cultivation of these parasites. The defined components include amino acids, carbohydrates, B vitamins, ascorbic acid, tocopherol, thioctic acid, nucleic acid precursors, trace metals, and phosphate buffers. The undefined components include a highly purified bovine serum albumin, a lipoprotein-cholesterol solution from bovine serum, and a dialyzable, autoclavable, water-soluble growth factor(s) having a molecular weight of less than 3 500 prepared from casein peptone. To date, studies on the growth requirements of E. histolytica, strain 200:NIH, show the following are essential for sustained multiplication of this amoeba: iron, glucose, biotin, folic acid, niacinamide, pantothenate, pyridoxal, riboflavin, thiamine, cysteine, an ammonium moiety (in addition to that present in cysteine), bovine serum albumin, lipoprotein-cholesterol, and casein peptone dialysate.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;This paper describes the preparation and composition of a serum-free medium for the cultivation of Entamoeba histolytica (3 strains) and 3 species of reptilian Entamoeba (at 35.5 °C and 24.0 °C respectively). [The original paper should be consulted for full details.] The medium (PDM-805) was a complex mixture of buffers, inorganic salts, trace metals, amino acids, carbohydrates, nucleic-acid precursors, vitamins, sodium acetate, detergent (Tween 80), and 3 undefined components: purified bovine serum albumin, casein peptone dialysate, and a lipoprotein-cholesterol solution prepared from bovine serum. In this medium Ent. histolytica multiplied about 35-fold after 100 h.J.R. Baker
KW  - culture media
KW  - culture techniques
KW  - Human diseases
KW  - parasites
KW  - Endamoebidae
KW  - Entamoeba
KW  - Entamoeba histolytica
KW  - Entamoeba invadens
KW  - protozoa
KW  - Sarcomastigophora
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Endamoebidae
KW  - Entamoeba
KW  - Entamoeba barreti
KW  - Entamoeba terrapinae
KW  - media
KW  - serum free media
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trypanosoma cruzi: flow cytometric analysis of developmental stage differences in DNA.
AU  - Nozaki, T.
AU  - Dvorak, J. A.
JO  - Journal of Protozoology
JF  - Journal of Protozoology
Y1  - 1991///
VL  - 38
IS  - 3
SP  - 234
EP  - 243
AD  - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920874325.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology; Tropical Diseases
N2  - Flow cytometry and DNA binding-specific fluorescent reagents were used to compare the total DNA, G-C, and A-T content of the epimastigote and trypomastigote stages of T. cruzi stocks. Significant total DNA differences of 2-12% between epimastigotes and trypomastigotes were found in 3 of 6 stocks studied. The epimastigote G-C content of 5 of 6 stocks were 4-8% higher than trypomastigotes, whereas the trypomastigote A-T content was 2.5-13% higher than the epimastigote A-T content. Although no obvious developmental stage association between total DNA and base composition was found, intrastage associations do exist. These observations were unaffected by nucleoprotein extraction implying that the observed differences between trypomastigotes and epimastigotes are not a consequence of nucleoprotein interference with DNA-binding fluorochromes. The nuclei and kinetoplasts of 4 T. cruzi stocks were isolated and analyzed. Developmental stage differences in nuclear and kinetoplast DNA are stock-dependent and base composition-dependent; both organelles contribute to the observed differences in DNA of intact cells. A nearly linear association between the percentage of total kinetoplast DNA, G-C, and A-T content was found. During metacyclogenesis, the G-C content decreases by approximately 7% as epimastigotes transform into metacyclic trypomastigotes. The decrease in G-C content precedes changes in morphology or in complement resistance. If the DNA changes are causally connected to developmental stage transformations in T. cruzi remains to be determined. However, the results could facilitate studies of the molecular genetic processes the parasite uses to successfully complete various phases of its life cycle and, consequently, the disease process it evokes.
KW  - developmental stages
KW  - differentiation
KW  - DNA
KW  - epimastigotes
KW  - Flow cytometry
KW  - Human diseases
KW  - parasites
KW  - trypomastigotes
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - deoxyribonucleic acid
KW  - growth phase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920874325&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Is the recommended daily allowance for vitamin D too low for the homebound elderly?
AU  - Gloth, F. M., III
AU  - Tobin, J. D.
AU  - Sherman, S. S.
AU  - Hollis, B. W.
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
Y1  - 1991///
VL  - 39
IS  - 2
SP  - 137
EP  - 141
SN  - 0002-8614
AD  - Gloth, F. M., III: Gerontology Research Center/Applied Physiology Section, National Institute on Aging/NIH, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19921446180.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 1406-16-2.  Subject Subsets: Human Nutrition
N2  - A population of sunlight-deprived elderly was studied to determine the daily intake of vitamin D and whether dietary intake was sufficient to maintain a normal vitamin D status. 22 subjects over 64 years old, with serum creatinine &lt;180 µmol/litre and confined indoors for more than 6 months were chosen from the community and a nursing home in Southeast Baltimore, USA. Food records over a 3-day period were obtained along with serum levels of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2 D) and intact parathyroid hormone (PTH). The mean daily vitamin D intake was over 2-fold greater than the adult recommended daily allowance (RDA) of 200 IU. The mean 25-OHD level was 40 nmol/litre (normal 25-138 nmol/litre), with 7 patients less than 25 nmol/litre. Of those participants with 25-OHD values less than 25 nmol/litre, the mean vitamin D intake was 467 IU (range 36-1096 IU). It is concluded that the current RDA seems inadequate for many older individuals who do not get sun exposure. This particular population of elderly is at risk to develop vitamin D deficiency and the associated complications.
KW  - guidelines
KW  - Old age
KW  - requirements
KW  - vitamin D
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - recommendations
KW  - Physiology of Human Nutrition (VV120) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning of the Plasmodium vivax Duffy receptor.
AU  - Fang, X. D.
AU  - Kaslow, D. C.
AU  - Adams, J. H.
AU  - Miller, L. H.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1991///
VL  - 44
IS  - 1
SP  - 125
EP  - 132
SN  - 0166-6851
AD  - Fang, X. D.: L.H. Miller, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872392.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - P. vivax and P. knowlesi merozoites invade only Duffy blood group-positive human erythrocytes. Soluble P. vivax and P. knowlesi merozoite proteins of MW 135 000 bind specifically to Duffy blood group determinants. The gene encoding a member of the Duffy receptor gene family of P. knowlesi was cloned. The molecular cloning of the presumptive Duffy receptor gene of P. vivax is reported, using the P. knowlesi gene as a probe. There is a single gene in P. vivax which codes for a protein of 1115 amino acids. The deduced amino acid sequence predicts a putative signal sequence at the amino-terminus and a transmembrane region followed by 45 amino acids at the carboxy-terminus. The 3 introns found at the 3′ end of the P. knowlesi gene were conserved in P. vivax, including high homology for the sequences of the introns. Comparison of the portion of the proteins amino to the transmembrane region between P. vivax and the partial sequence of P. knowlesi indicated at least 3 domains. Two homologous regions were separated by a non-homologous region. The cysteines in the homologous regions were conserved in number and position, indicating that the folding is similar and suggesting that these regions may be the Duffy blood group binding domains. In both P. vivax and P. knowlesi, the non-homologous region is hydrophilic and proline-rich, although the position of the prolines is not conserved. As prolines tend to stiffen a protein, this region may act as a 'hinge region' similar to those in the immunoglobulin gene family.
KW  - genes
KW  - Human diseases
KW  - molecular genetics
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodium knowlesi
KW  - Plasmodium vivax
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - biochemical genetics
KW  - cloning
KW  - Duffy receptor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intra-generic conservation and limited inter-strain variation in a protective minor surface antigen of Plasmodium knowlesi merozoites.
AU  - Waters, A. P.
AU  - Thomas, A. W.
AU  - Mitchell, G. H.
AU  - McCutchan, T. F.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1991///
VL  - 44
IS  - 1
SP  - 141
EP  - 144
SN  - 0166-6851
AD  - Waters, A. P.: Malaria Section, Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872394.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The DNA fragment containing the PK66 gene from the Nuri strain of P. knowlesi was cloned from size-selected DraI-digested genomic DNA ligated into SmaI-digested, phosphatase-treated PUC 9 and screened with the entire cDNA insert isolated from a clone (A+) of the H strain of P. knowlesi. The DNA clone was sequenced on both strands throughout the coding region directly from the double-stranded plasmid using a series of primers specific for the gene. The gene encoding PK66 contained no repetitive elements and the sequence of the Nuri version was almost identical to that reported for the H strain.
KW  - antigens
KW  - genes
KW  - Human diseases
KW  - merozoites
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - surface antigens
KW  - Apicomplexa
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - 66-kDA
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - strain variations
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and characterization of a species-specific repetitive DNA sequence from Loa loa.
AU  - Klion, A. D.
AU  - Raghavan, N.
AU  - Brindley, P. J.
AU  - Nutman, T. B.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1991///
VL  - 45
IS  - 2
SP  - 297
EP  - 305
SN  - 0166-6851
AD  - Klion, A. D.: Laboratory of Parasitic Diseases, National Institutes of Health, Bldg. 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872187.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - A genomic DNA library of L. loa was constructed in λgt11 using Eco-RI-digested DNA from microfilariae isolated from 2 West African patients. Screening with labelled L. loa DNA yielded several potential repetitive DNA clones. An MboI fragment of one of these, LL3M9, was identified and characterized. Sequence analysis of LL3M9 revealed an 839-bp fragment with an unusual 356-bp region containing 37 copies of the hexamer CTTAGG, many of which are arranged in repeated motifs of 12, 27 and 63 bp. This region shares many of the characteristics of eukaryotic satellite DNA. A synthetic oligonucleotide corresponding to the 27-bp repeated motif, LL3M9REP, was found to be both sensitive and species-specific by dot hybridization. Species specificity of LL3M9REP was confirmed by amplification of the repetitive region using genomic DNA as a template in the polymerase chain reaction.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;"A genomic DNA library of Loa loa was constructed in λgt11 using EcoRI-digested DNA from microfilariae isolated from 2 West African patients. Screening with labeled L. loa DNA yielded several potential repetitive DNA clones. An MboI fragment of 1 of these, LL3M9, was identified and characterized."
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - repetitive DNA
KW  - Loa loa
KW  - Nematoda
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - African eyeworm
KW  - biochemical genetics
KW  - DNA genomic library
KW  - DNA sequences
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mortality among aerial pesticide applicators and flight instructors: a reprint.
AU  - Cantor, K. P.
AU  - Booze, C. F.
JO  - Archives of Environmental Health
JF  - Archives of Environmental Health
Y1  - 1991///
VL  - 46
IS  - 2
SP  - 110
EP  - 116
SN  - 0003-9896
AD  - Cantor, K. P.: Environmental Epidemiology Branch, National Cancer Institute, 443 Executive Plaza North, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950500932.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Public Health
N2  - This is a reprint of an article which appeared previously in Archives of Environmental Health, 45: 295-302 (1990) to correct substantive errors introduced during production.
KW  - aerial spraying
KW  - agriculture
KW  - applicators
KW  - exposure
KW  - leukaemia
KW  - mortality
KW  - neoplasms
KW  - occupational hazards
KW  - occupations
KW  - pest control operators
KW  - pesticides
KW  - poisoning
KW  - spraymen
KW  - teratogens
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aerial and instructors
KW  - aerial applicators
KW  - blood cancer
KW  - cancers
KW  - death rate
KW  - leucaemia
KW  - leukemia
KW  - pesticide applicators
KW  - toxicosis
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pest and Weed Control Equipment (NN430) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A recombinant clone of Wuchereria bancrofti with DNA specificity for human lymphatic filarial parasites.
AU  - Raghavan, N.
AU  - McReynolds, L. A.
AU  - Maina, C. V.
AU  - Feinstone, S. M.
AU  - Jayaraman, K.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1991///
VL  - 47
IS  - 1
SP  - 63
EP  - 71
SN  - 0166-6851
AD  - Raghavan, N.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases. Bldg. 4, Rm. 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873812.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Helminthology
N2  - In order to understand the immune response to W. bancrofti and to aid in the diagnosis of W. bancrofti infections, recombinant antigens were identified from a W. bancrofti genomic expression library made in λgt11 using a pool of sera from infected Indian patients. One of the recombinant clones, λWbN1, containing a 2.5-kb insert, reacted strongly to a pool of sera from patients with lymphatic filariasis but not to normal human sera. In addition, this clone showed restricted specificity at the genomic level to the major lymphatic filarial parasites W. bancrofti and B. malayi but not to the closely related filarial parasite B. pahangi or to other filarial and non-filarial species tested. Nucleotide sequence analysis indicated the cloned DNA to have homology to myosin-like myofibrillar proteins. Polymerase chain reaction amplification initiated by specific synthetic oligomers amplified DNA in a species-specific manner from as little as 16 pg of isolated DNA or from one microfilaria.
KW  - antigens
KW  - DNA libraries
KW  - Filariids
KW  - helminths
KW  - molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - recombinant antigens
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stability of amphotericin B in 5% dextrose injection at 25°C.
AU  - Kintzel, P. E.
AU  - Kennedy, P. E.
JO  - American Journal of Hospital Pharmacy
JF  - American Journal of Hospital Pharmacy
Y1  - 1991///
VL  - 48
IS  - 8
SP  - 1681
EP  - 1681
SN  - 0002-9289
AD  - Kintzel, P. E.: Pharmaceutical Development Service Analytical Laboratory, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19921212884.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - Amphotericin B at concn of 0.47, 0.66 and 0.75 mg/ml in 5% dextrose injection was determined to be chemically stable and physically compatible when stored at 25°C for up to 24 h.
KW  - Amphotericin B
KW  - Antifungal agents
KW  - stability
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hyperglycemic properties of serotonin receptor antagonists.
AU  - Wozniak, K. M.
AU  - Linnoila, M.
JO  - Life Sciences
JF  - Life Sciences
Y1  - 1991///
VL  - 49
IS  - 2
SP  - 101
EP  - 109
SN  - 0024-3205
AD  - Wozniak, K. M.: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bldg.10 3C102, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911434842.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 50-67-9.  Subject Subsets: Human Nutrition; Animal Nutrition
N2  - Changes in the plasma glucose concentration of male NIH Swiss mice were measured after an injection of a non-selective (5-hydroxytryptamine, 5-HT) receptor antagonist (metergoline, 0.125-1.0 mg/kg body weight; methysergide, 2.5-10 mg/kg), a 5-HT2 and 5-HT10 antagonist (ritanserine, 0.62-2.4 mg/kg), or a 5-HT3 antagonist (3-tropanyl-3, 5-dichlorobenzoate, 5-10 mg/kg). The non-selective antagonists were hyperglycaemic at doses commonly used to antagonise 5-HT receptors. The 2 selective antagonists were only effective at a dose greater than that considered to be selective for their respective receptors. The results suggest that 5-HT systems play a role in maintaining glucose homeostasis and that 5-HT1 receptors may be particularly important in this function. The inherent hyperglycaemic properties of non-selective serotonin antagonists should be considered in studies using these agents to investigate glucose metabolism.
KW  - antagonists
KW  - blood
KW  - Serotonin
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 5-HT
KW  - 5-hydroxytryptamine
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Carboxy-terminal sequence conservation among variant-specific surface proteins of Giardia lamblia.
AU  - Mowatt, M. R.
AU  - Aggarwal, A.
AU  - Nash, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1991///
VL  - 49
IS  - 2
SP  - 215
EP  - 227
SN  - 0166-6851
AD  - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920876709.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Antigenic variation in G. lamblia [G. duodenalis] was studied by characterizing the expression and genomic organization of a variant-specific surface protein (VSP) gene. Transcripts from this gene, vsp1267, were abundant in the cloned variant WB/1267, but undetectable in the parental clone from which WB/1267 was derived or in variant progeny of WB/1267. Two identical copies of vsp1267 exist in the WB/1267 genome, separated by 3 kb and arranged as convergent transcription units. Primer extension sequencing and S1 nuclease protection analysis suggested that the 5′ untranslated region (UTR) of VSP1267 mRNA consists of a single nucleotide (nt). Primer extension sequencing mapped the site of VSP1267 transcript polyadenylation 25 nt beyond the termination codon. vsp1267 contained no introns and predicted a cysteine-rich polypeptide with features common to other VSPs. Comparison of vsp1267 with another VSP gene sequence revealed striking conservation, both at the nucleotide and amino acid levels, at the 3′ ends of the genes. An oligonucleotide derived from this region detected size-variant VSP transcripts in 4 of 5 G. lamblia clones analyzed, suggesting the general utility of this probe in studying VSP genes and their expression.
KW  - Antigenic variation
KW  - Human diseases
KW  - Molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Proteins
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - biochemical genetics
KW  - DNA sequences
KW  - Giardia lamblia
KW  - surface
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bovine somatotropin and the safety of cows' milk: National Institutes of Health technology assessment conference statement.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1991///
VL  - 49
IS  - 8
SP  - 227
EP  - 232
SN  - 0029-6643
AD  - Office of Medical Applications of Research, Building 1, Room 260, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910448191.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Registry Number: 9002-72-6.  Subject Subsets: Dairy Science; Agricultural Biotechnology; Human Nutrition; Dairy Science
N2  - The USA National Institutes of Health Consensus Conference was convened on 5-7 Dec. 1990 to evaluate available evidence on, and to resolve safety and efficacy questions related to the use of bovine somatotropin (GH) in the milk supply of the USA. The resultant statement was intended to advance understanding of the technology and issues, and to be useful to health professionals and the public. The statement was prepared by an expert panel on the basis of: 1. presentations by investigators working in areas relevant to the conference questions; 2. questions and statements from attendees at the open session of the conference; and 3. closed deliberations by the panel during the remainder of the second day and the morning of the third. The panel concluded that: 1. GH treatment increases milk yield of cows; 2. based on the data reviewed, GH administration does not appear to affect the general health of dairy cows appreciably; 3. the composition and nutritional value of milk from GH-treated cows is essentially the same as milk from untreated cows; 4. as currently used in the USA, meat and milk from GH-treated cows are as safe as those from untreated cows.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;This report by an expert panel reviews and evaluates available evidence on the safety and efficacy of the use of recombinant bovine somatotropin (rBST) in the United States' milk supply. The following topics were covered: the role of milk in human nutrition and methods for monitoring its safety for human consumption; comparative biology of human and bovine lactation and milk composition; the effect of administration of rBST on the milk production of cows and on the nutritional quality and hormonal content of their meat and milk; health effects on cows; health effects on man resulting from consumption of meat or milk from cows given rBST; and further animal and human research needed on use of rBST. It was concluded that rBST increased milk production of cows and did not appear to affect their general health appreciably. The composition and nutritive value of milk from treated cows was essentially the same as that from untreated cows, and as currently used in the USA, meat and milk from rBST-treated cows are as safe as those from untreated cows.
KW  - Biotechnology
KW  - Cows
KW  - foods
KW  - milk
KW  - nutritive value
KW  - public health
KW  - reviews
KW  - safety
KW  - Somatotropin
KW  - USA
KW  - cattle
KW  - man
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - growth hormone
KW  - National Institutes of Health Consensus conference
KW  - nutritional value
KW  - quality for nutrition
KW  - United States of America
KW  - Milk and Dairy Produce (QQ010) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Health Services (UU350) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Food Composition and Quality (QQ500) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cold tolerance and metabolic heat production in male C57BL/6J mice at different times of day.
AU  - Talan, M. I.
AU  - Tatelman, H. M.
AU  - Engel, B. T.
JO  - Physiology & Behavior
JF  - Physiology & Behavior
Y1  - 1991///
VL  - 50
IS  - 3
SP  - 613
EP  - 616
SN  - 0031-9384
AD  - Talan, M. I.: Laboratory of Behavioral Sciences, National Institute of Aging, National Institutes of Health, Gerontology Research Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19921443324.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - Nine-month-old male C57BL/6J mice 9 months old were subjected to 3-h cold stress tests (partial restraint at 6°C) at 09.00 or 13.00 h. Tests were repeated 3 times at 2-week intervals at the same time of day. Body temperature was estimated by colonic thermoprobe and metabolic heat production by indirect calorimetry during each test. All mice showed habituation to repeated cold exposures (an improvement of cold tolerance across tests) due to an increase in metabolic heat production. The values of metabolic heat production were similar during morning and afternoon testing; however, mice tested in the afternoon had consistently poorer cold tolerance, which indicated increased heat loss. Increased heat loss in mice of similar body weight and presumably similar body composition, suggests that there is less effective cold-induced skin vasoconstriction during the afternoon. It was hypothesised that the compromised skin vasomotor response during the afternoon cold exposure results from competing effects of vasodilation due to local autoregulation stimulated by a circadian reduction of cardiac output during the sleep phase, and vasoconstriction due to the cold stress.
KW  - Cold tolerance
KW  - diurnal variation
KW  - Heat production
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorigenesis
KW  - thermogenesis
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443324&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vegetables, fruits, and carotenoids and the risk of cancer.
AU  - Ziegler, R. G.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 1
SP  - 251S
EP  - 259S
SN  - 0002-9165
AD  - Ziegler, R. G.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941401707.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Human Nutrition
N2  - The protective effect of fruits, vegetables and carotenoids against cancer is reviewed. Evidence suggests that low intake of vegetables, fruits and carotenoids is consistently associated with increased risk of lung cancer. In addition, low levels of β-carotene in serum or plasma are consistently associated with the subsequent development of lung cancer. It is also suggested that vegetable and fruit intake may reduce the risk of cancers of the mouth, pharynx, larynx, oesophagus, stomach, colon, rectum, bladder and cervix though evidence for these cancers is less persuasive than for lung cancer.
KW  - carcinoma
KW  - carotenoids
KW  - fruits
KW  - neoplasms
KW  - prevention
KW  - vegetables
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - tetraterpenoids
KW  - vegetable crops
KW  - Human Nutrition (General) (VV100) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401707&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin C and cancer prevention: the epidemiologic evidence.
AU  - Block, G.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 1
SP  - 270S
EP  - 282S
SN  - 0002-9165
AD  - Block, G.: National Cancer Institute, EPN Room 313, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941401710.  Publication Type: Journal Article.  Language: English.  Number of References: 155 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Epidemiologic evidence of a protective effect of vitamin C for non-hormone-dependent cancers is discussed. Of 46 studies in which a dietary vitamin C index was calculated, 33 found significant protection compared with low intake. Of 29 additional studies that assessed fruit intake, 21 found significant protection. For cancers of the oesophagus, larynx, oral cavity and pancreas, evidence for a protective effect of vitamin C or some component in fruit was strong and consistent. For cancers of the stomach, rectum, breast and cervix there was also strong evidence. It is concluded that ascorbic acid, carotenoids and other factors in fruits and vegetables act jointly.
KW  - ascorbic acid
KW  - carcinoma
KW  - epidemiology
KW  - fruits
KW  - neoplasms
KW  - prevention
KW  - reviews
KW  - vegetables
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - vegetable crops
KW  - vitamin C
KW  - Human Nutrition (General) (VV100) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401710&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Studies evaluating antioxidants and β-carotene as chemopreventives.
AU  - Malone, W. F.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 1
SP  - 305S
EP  - 313S
SN  - 0002-9165
AD  - Malone, W. F.: Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941401715.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 7235-40-7.  Subject Subsets: Human Nutrition
N2  - The chemoprevention programme (National Cancer Institute, USA) is sponsoring 21 human efficacy studies. These trials are testing the potential of agents (β-carotene, folic acid, 13-cis retinoic acid, 4-hydroxyphenyl retinamide, vitamins C and E, and minerals) as inhibitors of a variety of cancers in man (colon, lung, oesophagus, cervix, bladder and skin). Study endpoints include overall incidence of cancer, incidence of specific cancers, rate of regression or progression of preneoplastic changes and changes in cellular or biochemical parameters. Study participants include volunteers from the general population; populations at high risk for cancer because of occupation, lifestyle or place of residence; persons with previously treated cancers; and persons with preneoplastic lesions. Study designs include single agent randomization, combination of agents and complete factorial designs.
KW  - antioxidants
KW  - beta-carotene
KW  - carcinoma
KW  - neoplasms
KW  - prevention
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Human Nutrition (General) (VV100) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401715&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary guidelines and the results of food consumption surveys.
AU  - Block, G.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 1
SP  - 356S
EP  - 357S
SN  - 0002-9165
AD  - Block, G.: National Cancer Institute, EPN Rm 313, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941401723.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Human Nutrition
N2  - The relation between dietary guidelines regarding fruits and vegetables and actual consumption in the USA is reviewed briefly.
KW  - consumption
KW  - diet
KW  - fruits
KW  - guidelines
KW  - reviews
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - recommendations
KW  - United States of America
KW  - vegetable crops
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401723&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antioxidants and aging.
AU  - Cutler, R. G.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 1
SP  - 373S
EP  - 379S
SN  - 0002-9165
AD  - Cutler, R. G.: Gerontology Research Center, National Institute on Aging, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19941401746.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 59-02-9, 9054-89-1, 69-93-2.  Subject Subsets: Human Nutrition
N2  - It is proposed that a common set of longevity determinant genes (LDG's) exist in all mammals independent of life span. It is suggested that antioxidants including superoxide dismutase, carotenoids, α-tocopherol and uric acid represent LDG's and may play a role in determining frequency of age-dependent diseases and duration of general health.
KW  - aging
KW  - alpha-tocopherol
KW  - antioxidants
KW  - carotenoids
KW  - superoxide dismutase
KW  - uric acid
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - tetraterpenoids
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401746&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aging and energy expenditure.
AU  - Vaughan, L.
AU  - Zurlo, F.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 4
SP  - 821
EP  - 825
SN  - 0002-9165
AD  - Vaughan, L.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19921440129.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - Whether sedentary energy expenditure is normal or lower in elderly people has not yet been clearly established. Energy expenditure for 24 h (24EE) and its different components were estimated by use of a respiratory chamber in elderly (17 male, 21 female; 71±6 years old, (mean±s.d.); 71.2±13.5 kg; 32±8% fat) and young (33 male, 31 female; 24±4 years old; 84.5±23.1 kg; 25±13% fat) subjects. The elderly subjects had lower mean height (P&lt;0.001), weight (P&lt;0.01) and fat-free mass (P&lt;0.001) but higher percentage body fat (P&lt;0.01) than did the young adults. Absolute 24EE, basal metabolic rate (BMR) and sleeping metabolic rate were lower (P&lt;0.01) in elderly than in young subjects. After differences in fat-free mass, fat mass and sex were adjusted for, only BMR was lower in the elderly subjects (P&lt;0.01). Despite a reduced adjusted BMR in older subjects, sedentary 24EE was decreased only in proportion to their reduced body size, suggesting that the lower energy intake reported in elderly people might be mainly related to lower physical activity in free-living conditions.
KW  - energy exchange
KW  - Old age
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440129&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy cost of physical activity on a metabolic ward in relationship to obesity.
AU  - Ferraro, R.
AU  - Boyce, V. L.
AU  - Swinburn, B.
AU  - Gregorio, M. de
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - 6
SP  - 1368
EP  - 1371
SN  - 0002-9165
AD  - Ferraro, R.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19921442621.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Human Nutrition
N2  - The energy cost of physical activity on a metabolic ward was derived from the difference between the energy requirement to maintain body weight on a metabolic ward and sedentary 24-h energy expenditure measured in a respiratory chamber in 56 non-diabetic men. The cost of physical activity was negatively correlated with body weight (r = -0.67, P&lt;0.0001) and with percent body fat (r = -0.48, P&lt;0.0005). In a subgroup of 15 men selected for strict weight stability (rate of weight change less than ±35 g daily), similar negative correlations were observed between energy cost of activity and body weight (r = -0.61, P&lt;0.01) and percent body fat (r = -0.51, P = 0.05). The ratio of active to sedentary energy expenditure, an index of physical activity, was also negatively correlated with body weight and percent body fat (r = -0.74, P&lt;0.002 and r = -0.61, P&lt;0.02, respectively). The results suggest that heavier subjects on a metabolic ward are less active and expend less energy in physical activity than do lighter subjects.
KW  - energy cost of activities
KW  - Obesity
KW  - physical activity
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442621&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Obesity in the Pima Indians: its magnitude and relationship with diabetes.
AU  - Knowler, W. C.
AU  - Pettitt, D. J.
AU  - Saad, M. F.
AU  - Charles, M. A.
AU  - Nelson, R. G.
AU  - Howard, B. V.
AU  - Bogardus, C.
AU  - Bennett, P. H.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 53
IS  - Suppl. 6
SP  - 1543
EP  - 1551
SN  - 0002-9165
AD  - Knowler, W. C.: Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.
N1  - Accession Number: 19921442742.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - Members of the Pima Indian population are obese, on average, as estimated by the body mass index (BMI). Young adults have had the highest BMIs and there have been modest increases in age- and sex-specific mean BMIs for the past 25 years. These observations suggest that the older adults have had less exposure to factors leading to obesity than have the younger adults. Compared with children studied early in this century, present-day Pima children are much heavier for height, suggesting that the degree of obesity has increased since that time. Obesity in the Pimas is familial and has complex relationships with non-insulin-dependent diabetes mellitus, a common disease in this population. Obesity predicts the development of diabetes; once people have diabetes, however, they tend to lose weight. Thus, obesity should not be studied in this population without also considering diabetes, which tends to limit the degree of obesity.
KW  - diabetes
KW  - Ethnic groups
KW  - incidence
KW  - obesity
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442742&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum.
AU  - Dhariwal, K. R.
AU  - Hartzell, W. O.
AU  - Levine, M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 54
IS  - 4
SP  - 712
EP  - 716
SN  - 0002-9165
AD  - Dhariwal, K. R.: M. Levine, Building 8, Room 415, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921442820.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 50-81-7, 490-83-5.  Subject Subsets: Human Nutrition
N2  - To investigate whether circulating ascorbic acid in man is protein-bound or free and whether ascorbic acid exists in its reduced form alone as ascorbic acid or in its reduced and oxidized forms (ascorbic acid and dehydroascorbic acid, respectively) ascorbic acid and dehydroascorbic acid were determined by using HPLC with coulometric electrochemical detection, and protein binding was determined by centrifugal ultrafiltration. Ascorbic acid was free in plasma and serum of normal, healthy volunteers, (10 men, 10 women). Ascorbic acid was detectable only in its reduced form. However, dehydroascorbic acid could be made to appear in samples processed under oxidizing conditions. Because circulating ascorbic acid is free and is detected only in its reduced form, ascorbic acid may be available without intermediates for peripheral utilization. Dehydroascorbic acid may not be present in plasma and serum of normal humans unless assay conditions permit ascorbic acid oxidation.
KW  - Ascorbic acid
KW  - blood
KW  - Dehydroascorbic acid
KW  - estimation
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442820&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid and oxidative inactivation of proteins.
AU  - Stadtman, E. R.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 54
IS  - Suppl. 6
SP  - 1125S
EP  - 1128S
SN  - 0002-9165
AD  - Stadtman, E. R.: National Institutes of Health, 9000 Rockville Pike, Building 3, Room 222, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446360.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 56 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - A number of active oxygen species are probably implicated in the aetiology or manifestation of several pathological conditions, including aging, arthritis, carcinogenesis, atherosclerosis and muscular dystrophy. Ascorbate plays a key role in protecting cells against oxidative damage. Paradoxically, in the presence of Fe3+ or Cu2+, ascorbate can promote the generation of the same reactive oxygen species (OH, O-2, H2O2, and ferryl ion) it is known to destroy. This prooxidant activity derives from the ability of ascorbate to reduce Fe3+ or Cu2+ to Fe2+ or Cu+, respectively, and to reduce O2 to O2- and H2O2. Damage to nucleic acid and proteins results from the binding of either Fe2+ or Cu+ to metal binding sites on these macromolecules followed by reaction of the metal complexes with H2O2; this leads to the production of active oxygen species that attack functional groups at or near the metal binding sites.
KW  - ascorbic acid
KW  - oxidation
KW  - Proteins
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Ascorbic acid, biologic functions and relation to cancer
KW  - United States of America
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446360&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy.
AU  - Peterkofsky, B.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 54
IS  - Suppl. 6
SP  - 1135S
EP  - 1140S
SN  - 0002-9165
AD  - Peterkofsky, B.: Building 37 Room 4C-18, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446362.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 54 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Ascorbic acid deficiency is associated with defective connective tissue, particularly in wound healing. Ascorbate is required for hydroxylation of proline residues in procollagen and hydroxyproline stabilizes the collagen triple helical structure. Consequently, ascorbate stimulates procollagen secretion. However, collagen in synthesis in ascorbate-deficient guineapigs is decreased with only moderate effects on proline hydroxylation. Proteoglycan synthesis, which does not require ascorbate, also is decreased and both effects are correlated with the extent of weight loss during scurvy. Fasting, with ascorbate supplementation, produces similar effects. Both functions are inhibited in cells cultured in sera from scorbutic or starved guineapigs and inhibition is reversed with insulin-like growth factor (IGF)-I. The inhibitor seems to consist of 2 IGF-binding proteins induced during ascorbic acid deficiency and starving and may be responsible for inhibition of collagen and proteoglycan synthesis in vivo.
KW  - ascorbic acid
KW  - collagen
KW  - Scurvy
KW  - synthesis
KW  - USA
KW  - guineapigs
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Ascorbic acid, biologic functions and relation to cancer
KW  - guinea pigs
KW  - United States of America
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446362&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid and in situ kinetics: a new approach to vitamin requirements.
AU  - Levine, M.
AU  - Dhariwal, K. R.
AU  - Washko, P. W.
AU  - Butler, J. D.
AU  - Welch, R. W.
AU  - Wang, Y.
AU  - Bergsten, P.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 54
IS  - Suppl. 6
SP  - 1157S
EP  - 1162S
SN  - 0002-9165
AD  - Levine, M.: Building 8, Room 415, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446367.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 42 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Ascorbic acid requirements are based on preventing the deficiency disease scurvy and on urinary excretion of vitamin C. The first quantitative approach to determining optimal requirements for ascorbic acid and other vitamins, called kinetics in situ is proposed. Kinetics in situ biochemically is based on the application of Michaelis-Menten reaction kinetics to ascorbic acid-dependent reactions in situ. Clinically kinetics in situ is based on estimating vitamin availability to tissues so that cell-specific reactions can occur. The biochemical concepts of kinetics in situ are verified for the first time through studying ascorbic acid regulation of norepinephrine biosynthesis. The principles of kinetics in situ can now be applied to man and human cells and for determining optimal requirements for ascorbic acid and for other vitamins.
KW  - Ascorbic acid
KW  - estimation
KW  - requirements
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Ascorbic acid, biologic functions and relation to cancer
KW  - United States of America
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446367&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid and the eye.
AU  - Garland, D. L.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 54
IS  - Suppl. 6
SP  - 1198S
EP  - 1202S
SN  - 0002-9165
AD  - Garland, D. L.: National Institutes of Health, Building 6, Room 235, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446374.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 78 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Literature on transport and function of ascorbic acid in ocular tissues is reviewed. The role of ascorbic acid in various regions of the eye is not well understood. It appears one important function of this compound is protection against oxidative damage, particularly photoinduced damage. In contrast, data are also reviewed that suggest ascorbic acid may participate in the oxidative modification of lens proteins seen with aging.
KW  - ascorbic acid
KW  - Eyes
KW  - reviews
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Ascorbic acid, biologic functions and relation to cancer
KW  - United States of America
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446374&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid in human neutrophils.
AU  - Washko, P.
AU  - Rotrosen, D.
AU  - Levine, M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991///
VL  - 54
IS  - Suppl. 6
SP  - 1221S
EP  - 1227S
SN  - 0002-9165
AD  - Washko, P.: M. Levine, Building 8, Room 415, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446378.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 45 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - The uptake and distribution of ascorbic acid and the effect of extracellular glucose on ascorbic acid transport were investigated in human neutrophils. Freshly isolated neutrophils contained ascorbic acid 1.0 to 1.4 mmol/litre, at least 94% of which was present unbound in the cytosol. Intracellular ascorbic acid was found only in the reduced form. The presence of physiologic amounts of ascorbic acid in the extracellular buffer led to the accumulation of millimolar concentrations of ascorbic acid intracellularly. Accumulation was mediated by a high- and a low-affinity transport activity. The high-affinity transport activity had an apparent Km of 2 to 5 µmol/litre whereas the low-affinity transport activity had an apparent Km of 6 to 7 mmol/litre. Glucose inhibited uptake and accumulation of ascorbic acid by both transport activities in a concentration-dependent fashion. Glucose-induced inhibition of both ascorbic acid transport activities was completely reversible.
KW  - Ascorbic acid
KW  - neutrophils
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Ascorbic acid, biologic functions and relation to cancer
KW  - United States of America
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446378&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolate and epitope variability in susceptibility of Giardia lamblia to intestinal proteases.
AU  - Nash, T. E.
AU  - Merritt, J. W.
AU  - Conrad, J. T.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1991///
VL  - 59
IS  - 4
SP  - 1334
EP  - 1340
SN  - 0019-9567
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808679.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology
N2  - The surface antigens of Giardia lamblia [G. duodenalis] differ. To determine whether the unique surface antigens found in variants and isolates could differentially protect the parasite from digestion by intestinal proteases, G. lamblia clones WB-2X (WB), GS/M-H7 (GS/M), and B6, each of which expresses a unique surface variant antigen, were exposed to α-chymotrypsin and trypsin at concentrations up to 20 mg/ml in culture medium. The number of surviving trophozoites and morphologic changes were assessed over time. After 24 h, there was a significant decrease in the number of surviving trophozoites of WB (80.5 and 94.2% for trypsin and α-chymotrypsin treatments, respectively, compared with controls) and B6 (78.6 and 95.5% for trypsin and α-chymotrypsin treatments, respectively compared with controls) at 10 mg of enzyme per ml compared with culture medium alone. Cytotoxicity was prevented by the presence of soybean trypsin inhibitor, indicating the effects were due to protease activity. In contrast, there was no significant cytotoxicity after exposure of GS/M to either enzyme at the same enzyme concentration. After exposure to α-chymotrypsin, susceptible G. lamblia became rounded and then lysed, but after exposure to trypsin, G. lamblia appeared plastered onto the surface of the well and was intertwined and surrounded by finely granular material. Effects were concentration and time dependent; at least 6 h of treatment was required to observe changes 12 to 18 h later. Trophozoites surviving α-chymotrypsin or trypsin exposure became stably resistant to protease treatment. In vitro, the variant surface antigen of GS/M, but not those of WB or B6, resisted digestion by trypsin or α-chymotrypsin, suggesting that the variant surface antigens impart susceptibility or resistance to digestion. The initial surface variant antigens of WB and B6 were replaced in resistant cultures. Trophozoites differ in their ability to survive after exposure to intestinal proteases, which may enable certain G. lamblia isolates or isolates possessing certain surface variant antigens to survive in the small intestine.
KW  - antigenic variation
KW  - Antigens
KW  - Enzymes
KW  - Epitopes
KW  - Human diseases
KW  - Immune evasion
KW  - parasites
KW  - surface antigens
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - antigenic polymorphism
KW  - antigenicity
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808679&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chromosomal rearrangement in Candida stellatoidea results in a positive effect on phenotype.
AU  - Wickes, B. L.
AU  - Golin, J. E.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1991///
VL  - 59
IS  - 5
SP  - 1762
EP  - 1771
SN  - 0019-9567
AD  - Wickes, B. L.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911209094.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - When type I C. stellatoidea is plated onto sucrose agar at levels in excess of 108 cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements were studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement.
KW  - chromosomes
KW  - genetics
KW  - phenotypes
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida stellatoidea
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209094&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cryptococcus neoformans serotype A glucuronoxylomannan-protein conjugate vaccines: synthesis, characterization, and immunogenicity.
AU  - Devi, S. J. N.
AU  - Schneerson, R.
AU  - Egan, W.
AU  - Ulrich, T. J.
AU  - Bryla, D.
AU  - Robbins, J. B.
AU  - Bennett, J. E.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1991///
VL  - 59
IS  - 10
SP  - 3700
EP  - 3707
SN  - 0019-9567
AD  - Devi, S. J. N.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911210274.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health; Tropical Diseases
N2  - C. neoformans serotype A glucuronoxylomannan (GXM) conjugate vaccines were synthesized under conditions suitable for human use to prevent disseminated cryptococcosis. The purified, sonicated GXM was derivatized with adipic acid dihydrazide through either hydroxyl or carboxyl groups and then covalently bound to tetanus toxoid (TT) or Pseudomonas aeruginosa exoprotein A (rEPA). The immunogenicity of these conjugates was evaluated in BALB/c and general purpose mice by subcutaneous injection in saline. The conjugates elicited higher GXM antibody responses than GXM alone. Booster immunoglobulin G (IgG) and IgM responses were elicited by all conjugates in BALB/c mice. The conjugates prepared through hydroxyl activation (GXM-TT2 and GXM-rEPA) were more immunogenic than the one prepared through carboxyl activation (GXM-TT1). GXM antibody response was enhanced by the administration of monophosphoryl lipid A 2 d following the injection of GXM-TT2 (P&lt;0.03). The conjugates also elicited IgG antibodies to the carrier proteins. Gel diffusion tests using conjugate-induced hyperimmune sera and chemically modified GXMs suggested that the specificity of GXM-TT1-induced antibodies was conferred by the O-acetyl groups. Hyperimmune sera generated by GXM-TT2 precipitated with the chemically unmodified and the de-O-acetylated GXMs but not with the carboxyl-reduced and de-O-acetylated GXM. GXM-TT2-induced hyperimmune serum also precipitated with the capsular polysaccharides of C. neoformans serotypes D, B and C. It is concluded that the conjugate vaccines prepared through hydroxyl activation of the GXM are sufficiently immunogenic and appear to be suitable for clinical evaluation.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors conclude from studies in BALB/c and other mice that the conjugate vaccines prepared through hydroxyl activation of the Cryptococcus neoformans serotype A glucuronoxylomannan are "sufficiently immunogenic and appear to be suitable for clinical evaluation".Carolyn A. Brown
KW  - immunology
KW  - vaccines
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - glucuronoxylomannan-protein
KW  - serotype A
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210274&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selection of genetic variants from Plasmodium clones.
AU  - Dolan, S. A.
AU  - Miller, L. H.
AU  - Wellems, T. E.
JO  - Acta Leidensia
JF  - Acta Leidensia
Y1  - 1991///
VL  - 60
IS  - 1
SP  - 93
EP  - 99
SN  - 0065-1362
AD  - Dolan, S. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803131.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 22 ref. Subject Subsets: Protozoology
N2  - Clones of Plasmodium alter their antigenic profile or invasion phenotype when presented with specific challenges. Two examples, using Plasmodium knowlesi and P. falciparum, are reviewed which may represent different genetic mechanisms of adaptation to selection pressures. In these 2 examples, immune pressure and changes in the carbohydrate structure of the erythrocyte were used to challenge parasite clones. In both cases, the parasite adapted readily to produce variants that were no longer affected by the selection pressure. It is suggested that vaccine trials should include studies on the selection of mutations in the target antigen.
KW  - clones
KW  - genetic variation
KW  - malaria
KW  - parasites
KW  - North America
KW  - USA
KW  - Plasmodium falciparum
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803131&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins.
AU  - Falgout, B.
AU  - Pethel, M.
AU  - Zhang, Y. M.
AU  - Lai, C. J.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1991///
VL  - 65
IS  - 5
SP  - 2467
EP  - 2475
SN  - 0022-538X
AD  - Falgout, B.: C.J. Lai, Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920511806.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The cleavages at the junctions of the flavivirus nonstructural (NS) proteins NS2A/NS2B, NS2B/NS3, NS3/NS4A and NS4B/NS5 share an amino acid sequence motif and are presumably catalysed by a virus-encoded protease. Recombinant vaccinia viruses expressing various portions of the NS region of the dengue virus type 4 polyprotein were constructed. By analysing the immune precipitates of 35S-labelled lysates of recombinant virus-infected cells, the NS2A/NS2B, NS2B/NS3 and NS3/NS4A cleavages were monitored. A polyprotein composed of NS2A, NS2B and the N-terminal 184 amino acids of BS3 was cleaved at the NS2A/NS2B and NS2B/NS3 junctions, whereas a similar polyprotein containing only the first 77 amino acids of NS3 was not. This finding is consistent with the proposal that the N-terminal 180 amino acids of NS3 constitute a protease domain. Polyproteins containing NS2A and NS3 with large in-frame deletions of NS2B were not cleaved at the NS2A/NS2B or NS2B/NS3 junctions. Coinfection with a recombinant expressing NS2B complemented these NS2B deletions for NS2B/NS3 cleavage and probably also for NS2A/NS2B cleavage. Thus, NS2B is also required for the NS2A/NS2B and NS2B/NS3 cleavages and can act in trans. Other experiments showed that NS2B was needed, apparently in cis, for NS3/NS4A cleavage and for a series of internal cleavages in NS3. Indirect evidence that NS3 can also act in trans was obtained. Models are discussed for 2-component protease activity requiring both NS2B and NS3.
KW  - Arboviruses
KW  - Proteinases
KW  - proteolysis
KW  - viral proteins
KW  - Dengue virus
KW  - Flaviviridae
KW  - Flavivirus
KW  - Vaccinia virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - arthropod-borne viruses
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511806&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of CD4+ and CD8+ T cells in murine resistance to street rabies virus.
AU  - Perry, L. L.
AU  - Lodmell, D. L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1991///
VL  - 65
IS  - 7
SP  - 3429
EP  - 3434
SN  - 0022-538X
AD  - Perry, L. L.: D.L. Lodmell, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19912254371.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - Mice of the SJL/J and BALB/cByJ inbred strains are naturally resistant to street rabies virus (SRV) injected via the i.p. route. To determine the cellular mechanism of resistance, monoclonal antibodies specific for CD4+ or CD8+ T cells were used to deplete the respective cell population in SRV-infected animals. Elimination of CD4+ T-helper cells abrogated the production of immunoglobulin G (IgG) neutralizing antibodies in response to rabies virus infection and reversed the resistant status of SJL/J and BALB/cByJ mice. In contrast, in vivo depletion of CD8+ cytotoxic T cells had no effect on the host resistance to SRV. These results indicate that serum neutralizing antibodies of the IgG class are a primary immunological mechanism of defence against rabies virus infection in this murine model. CD8+ cytoxic T lymphocytes, which have been shown to transfer protection in other rabies virus systems, appear to have no role in protecting mice against i.p. injected SRV.
KW  - disease resistance
KW  - Experimental infection
KW  - Rabies
KW  - T lymphocytes
KW  - viral diseases
KW  - Virus neutralization
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease resistence
KW  - experimental transmission
KW  - Monclonal antibodies
KW  - resistance to disease
KW  - T cells
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912254371&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The comparative fine structure and surface glycoconjugate expression of three life stages of Leishmania major.
AU  - Pimenta, P. F. P.
AU  - Saraiva, E. M. B.
AU  - Sacks, D. L.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1991///
VL  - 72
IS  - 2
SP  - 191
EP  - 204
SN  - 0014-4894
AD  - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910871069.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The cellular ultrastructure and surface glycoconjugate expression of 3 life-cycle stages of L. major (MHOM/IL/80/FRIEDLIN) were compared. Noninfective logarithmic phase promastigotes (LP) are immature cell bearing a thin cell coat, short flagellum, small and empty flagellar pocket, and a loose cytoplasm filled with profiles of ER and large Golgi complex. LP also contain subpopulations of maturing cells containing less ER and Golgi and synthesizing cytoplasmic granules of different size, number, and electrondensity. Infective or metacyclic promastigotes (MP) are fully differentiated nondividing forms with a thickened, prominent cell coat, long flagellum, distended flagellar pocket filled with secretory material, and few cytoplasmic organelles other than abundant electron-dense granules. Tissue amastigotes also contain electron-dense cytoplasmic granules, their flagellar pockets are also enlarged and contain secretory material, but they lack a discernable cell coat. Immunogold labelling of GP63 on the cell surface was extensive only on amastigotes. Promastigote GP63 appeared to be masked by the presence of a densely packed lipophosphoglycan (LPG) coat which was extensively labelled on the entire surface of MP and LP. An elongated, developmentally modified form of LPG was abundantly labelled only on MP. LPG was poorly labelled on amastigotes, arguing that the promastigote cell coat is a stage-specific structure which is lost during intracellular transformation.
KW  - amastigotes
KW  - Biochemistry
KW  - comparisons
KW  - Developmental stages
KW  - enzymes
KW  - Human diseases
KW  - parasites
KW  - promastigotes
KW  - proteinases
KW  - ultrastructure
KW  - Leishmania major
KW  - protozoa
KW  - Sarcomastigophora
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - growth phase
KW  - proteases
KW  - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871069&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and caucasians.
AU  - Lillioja, S.
AU  - Nyomba, B. L.
AU  - Saad, M. F.
AU  - Ferraro, R.
AU  - Castillo, C.
AU  - Bennett, P. H.
AU  - Bogardus, C.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1991///
VL  - 73
IS  - 4
SP  - 866
EP  - 876
SN  - 0021-972X
AD  - Lillioja, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix Indian Medical Center/National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19921442614.  Publication Type: Journal Article.  Language: English.  Number of References: 66 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Pima Indians (Arizona, USA) have the highest reported prevalence rate of non-insulin-dependent diabetes mellitus (NIDDM) in the world. 81 white adults were compared with 211 Pima Indian non-diabetic subjects similar in age, sex, degree of obesity and glucose tolerance. During a hyperinsulinaemic euglycaemic clamp at physiological insulin concentrations, Pima Indians were 17% more insulin resistant than whites after accounting for any differences in degree of obesity (P&lt;0.0001). During oral glucose tolerance testing, mean plasma insulin concentrations were 33% higher in the Pimas (P&lt;0.0001), but these differences were largely explained by the greater insulin resistance in the Pimas. Insulin clearance did not differ between the races. However, early insulin responses were exaggerated in the Indians and not explained by insulin resistance. After accounting for differences in insulin action, plasma insulin concentrations in Pima Indians were 50% higher than those in whites 3 to 5 min after intravenous glucose (P&lt;0.0001), 38% higher 10 min after the end of a meal (P&lt;0.0001) and 20% higher 30 min after an oral glucose load (P&lt;0.006). Data suggest that in addition to insulin resistance, Pima Indians have exaggerated early insulin release and increased β-cell mass or enhanced β-cell sensitivity to glucose. The data argue against low or delayed insulin secretion as primary factors leading to NIDDM in Pima Indians and favour insulin resistance as the underlying and initiating cause of the disease.
KW  - diabetes
KW  - Ethnic groups
KW  - insulin
KW  - resistance
KW  - risk
KW  - Arizona
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mountain States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southwestern States of USA
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Demographic and behavioral predictors of Trichomonas vaginalis infection among pregnant women.
AU  - Cotch, M. F.
AU  - Pastorek, J. G., II
AU  - Nugent, R. P.
AU  - Yerg, D. E.
AU  - Martin, D. H.
AU  - Eschenbach, D. A.
JO  - Obstetrics and Gynecology (New York)
JF  - Obstetrics and Gynecology (New York)
Y1  - 1991///
VL  - 78
IS  - 6
SP  - 1087
EP  - 1092
SN  - 0029-7844
AD  - Cotch, M. F.: NIAID Division of Microbiology and Infectious Diseases, National Institutes of Health, Control Data Building, Room 3A24, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920881091.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Protozoology
N2  - A study was made of the demographic and behavioral predictors of infection with Trichomonas vaginalis among pregnant women in the USA. Among 13 816 women from 6 urban clinic centres (in New York, Seattle, Oklahoma City, San Antonio, New Orleans), the prevalence rate by culture at mid-pregnancy was 12.6%. Women colonized with T. vaginalis were significantly more likely to be black, cigarette smokers, unmarried, and less educated. Several behavioural factors associated with T. vaginalis infection included greater numbers of sexual partners throughout life, and in the last year, and a history of gonorrhoea. Women using barrier or oral contraception in the 6 months before becoming pregnant were far less likely to become colonized with T. vaginalis.
KW  - epidemiology
KW  - females
KW  - human diseases
KW  - parasites
KW  - pregnancy
KW  - Louisiana
KW  - New York
KW  - North America
KW  - Oklahoma
KW  - Texas
KW  - USA
KW  - Washington
KW  - man
KW  - protozoa
KW  - sarcomastigophora
KW  - trichomonadidae
KW  - Trichomonas vaginalis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Protozoa
KW  - Trichomonadida
KW  - Sarcomastigophora
KW  - Trichomonas
KW  - Trichomonadidae
KW  - Delta States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Gulf States of USA
KW  - West South Central States of USA
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - Great Plains States of USA
KW  - Southern Plains States of USA
KW  - Southwestern States of USA
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - gestation
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881091&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intake of tapwater and total water by pregnant and lactating women.
AU  - Ershow, A. G.
AU  - Brown, L. M.
AU  - Cantor, K. P.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991///
VL  - 81
IS  - 3
SP  - 328
EP  - 334
SN  - 0090-0036
AD  - Ershow, A. G.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910447494.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 7732-18-5.  Subject Subsets: Dairy Science; Human Nutrition
N2  - Despite theoretically higher requirements for water due to the physiological demands of pregnancy and lactation, little is known of the actual ranges of intake in pregnant and lactating women. Population-based estimates of total water and tap-water intake in women of reproductive age were derived using data from the 1977-78 USDA Nationwide Food Consumption Survey. Three-day av. intakes were calculated for 188 pregnant women, 77 lactating women and 6201 non-pregnant, non-lactating control women. Total water intake (mean±s.d.) was 1940±686 g/day (median 1835) for control women, 2076±743 g/day (median 1928) for pregnant women and 2242±658 g/day (median 2164) for lactating women. Tap-water intake was 1157±635 g/day (median 1065) for control women, 1189±699 g/day (median 1063) for pregnant women and 1310±591 g/day (median 1330) for lactating women. Total water intake was ≥3000 g/day among 7% of control women, 11% of pregnant women and 13% of lactating women. Tap-water intake was ≥2000 g/day among 10% of control women, 15% of pregnant women and 8% of lactating women. These results should be useful in estimating amounts of nutrients and toxic substances that women of reproductive age obtain through the water supply.
KW  - intake
KW  - lactation
KW  - pregnancy
KW  - tap water
KW  - Water
KW  - water intake
KW  - Women
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gestation
KW  - human lactation
KW  - Human Nutrition (General) (VV100) 
KW  - Milk and Dairy Produce (QQ010) 
KW  - Diet Studies (VV110) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of soy products in reducing risk of cancer.
AU  - Messina, M.
AU  - Barnes, S.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1991///
VL  - 83
IS  - 8
SP  - 541
EP  - 546
SN  - 0027-8874
AD  - Messina, M.: Diet and Cancer Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921442185.  Publication Type: Journal Article.  Language: English.  Number of References: 83 ref. Subject Subsets: Human Nutrition; Soyabeans
N2  - This commentary is based on the findings of a recent workshop on the role of soya products in cancer prevention. Its objectives were to evaluate the relationship between the risk of certain cancers and consumption of soyabeans, soyabean products and specific components of soyabeans, and to recommend research initiatives aimed at clarifying this relationship. It was concluded that there were sufficient data to justify studying the impact of soyabean intake on cancer risk in humans and to carry out basic research on the absorption, metabolism and physiology of potential anticarcinogens for humans in soyabean components.
KW  - Carcinoma
KW  - prevention
KW  - reviews
KW  - soyabean products
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - soybean products
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442185&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid: biologic functions and relation to cancer.
AU  - Henson, D. E.
AU  - Block, G.
AU  - Levine, M.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1991///
VL  - 83
IS  - 8
SP  - 547
EP  - 550
SN  - 0027-8874
AD  - Henson, D. E.: Early Detection Branch, Division of Cancer Prevention and Control, Executive Plaza North, Rm 305, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921442186.  Publication Type: Journal Article.  Language: English.  Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - This report is based on the findings of a symposium held at the National Institutes of Health, September 10-12, 1990, when the antioxidant, enzymic, immune and cancer-related functions of ascorbic acid were discussed. It was concluded that vitamin C has multiple complex effects on a variety of biological activities. Some effects were the result of interaction of vitamin C and enzymes, whereas others are independent of enzymic function, apparently related to its chemical properties and not to its role as a vitamin. A unifying principle to explain the seemingly unrelated effects of vitamin C is needed. Any role for ascorbate in prevention and treatment of cancer will be established only through increased knowledge of its biological actions.
KW  - ascorbic acid
KW  - Carcinoma
KW  - metabolism
KW  - prevention
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Case-control study of canine malignant lymphoma: positive association with dog owner's use of 2,4-dichlorophenoxyacetic acid herbicides.
AU  - Hayes, H. M.
AU  - Tarone, R. E.
AU  - Cantor, K. P.
AU  - Jessen, C. R.
AU  - McCurnin, D. M.
AU  - Richardson, R. C.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1991///
VL  - 83
IS  - 17
SP  - 1226
EP  - 1231
SN  - 0027-8874
AD  - Hayes, H. M.: Environmental Epidemiology Branch, National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19922267230.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4.  Subject Subsets: Veterinary Science; Horticultural Science; Veterinary Science; Weeds
N2  - A hospital-based case-control study of pet dogs examined the risk of developing canine malignant lymphoma associated with the use of chemicals in and about the home. Information from a self-administered owner questionnaire and/or a telephone interview of about 491 cases, 466 nontumour controls, and 479 tumour controls indicated that owners in households with dogs that developed malignant lymphoma applied 2,4-dichlorophenoxyacetic acid (2,4-D) herbicides to their lawn and/or employed commercial lawn care companies to treat their yard more frequently than control owners (odds ratio = 1.3). In addition, the risk of canine malignant lymphoma rose to a 2-fold excess with 4 or more yearly owner applications of 2,4-D. These findings are consistent with occupational studies in man, which have reported modest associations between agricultural exposure to 2,4-D and increased risk of non-Hodgkin's lymphoma, the histology and epidemiology of which are similar to those of canine malignant lymphoma. The present study suggests that human health implications of 2,4-D exposure in the home environment should receive further investigation.
KW  - 2,4-D
KW  - application
KW  - Carcinogens
KW  - control
KW  - Herbicides
KW  - lawns and turf
KW  - lymphoma
KW  - neoplasms
KW  - ornamental plants
KW  - Pets
KW  - safety
KW  - toxicology
KW  - weeds
KW  - USA
KW  - dogs
KW  - man
KW  - plants
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - (2,4-dichlorophenoxy)acetic acid
KW  - cancers
KW  - lawns and sports turf
KW  - ornamentals
KW  - pet animals
KW  - United States of America
KW  - weedicides
KW  - weedkillers
KW  - Pets and Companion Animals (LL070) 
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Weeds and Noxious Plants (FF500) 
KW  - Occupational Health and Safety (VV900) 
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hypochloremic metabolic alkalosis from ingestion of a chloride-deficient infant formula: outcome 9 and 10 years later.
AU  - Malloy, M. H.
AU  - Graubard, B.
AU  - Moss, H.
AU  - McCarthy, M.
AU  - Gwyn, S.
AU  - Vietze, P.
AU  - Willoughby, A.
AU  - Rhoads, G. G.
AU  - Berendes, H.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1991///
VL  - 87
IS  - 6
SP  - 811
EP  - 822
SN  - 0031-4005
AD  - Malloy, M. H.: Epidemiology Branch/PRP, National Institute of Child Health and Human Development, Executive Plaza North, Room 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911438594.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 16887-00-6.  Subject Subsets: Human Nutrition; Soyabeans
N2  - In 1978 and 1979 two infant formulae produced in the USA, Neo-Mull-Soy and Cho-Free, were found to be deficient in chloride. The Centers for Disease Control received reports that hypochloraemic metabolic alkalosis (HMA) had developed in 141 children as a result of exposure to these formulae. Of these children 35 were examined at 9 and 10 years old and compared with a group of 32 children who were exposed to the chloride-deficient formulae but were not reported to experience HMA and a group of 61 children who received chloride-sufficient soya formulae in infancy. The control children were matched to the HMA children on sex, race, age and maternal education. Growth characteristics, performance on the Wechsler Intelligence Scale for Children-Revised (WISC-R), the Boston Naming Test, the Rey-Osterrieth Test, the Clinical Evaluation of Language Fundamentals Revised (CELF-R), and subtests from several other speech and language tests were compared across the groups. After adjustment for family income and the level of the father's education, significantly lower scores were observed in the HMA children on the WISC-R Arithmetic subtest (mean = 10.5) compared with the soya control children (mean = 12.0, P&lt;0.05)and on the WISC-R Coding subtest (mean = 9.0) compared with the soya control children (mean = 10.8, P&lt;0.01). All the WISC-R subtest scores were within the normal range. Although no significant differences occurred on the CELF-R between groups, the risk of an HMA child falling below the range expected for a standard population was increased on the CELF-R Composite Total, Receptive and Expressive Language scores: risk ratios = 2.14, 2.14, and 3.03 respectively. Significant differences were observed between the children exposed, both HMA and non-HMA children, and the soya control children for behavioural problems as determined by the Achenbach Childhood Behavioral Checklist. It is concluded that as a group, children with documented HMA appear to have recovered from their growth failure and have normal cognitive development. They may, however, be at risk for deficits in language skills that require expressive language abilities.
KW  - alkalosis
KW  - Children
KW  - chloride
KW  - deficiency
KW  - infant formulae
KW  - soyabean products
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - infant formula
KW  - infant formulas
KW  - soybean products
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Early formula supplementation of breast-feeding.
AU  - Kurinij, N.
AU  - Shiono, P. H.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1991///
VL  - 88
IS  - 4
SP  - 745
EP  - 750
SN  - 0031-4005
AD  - Kurinij, N.: Collaborative Clinical Research Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19921442451.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - Factors influencing early formula supplementation in breast-fed neonates were examined among 726 women who were delivered of their first child in 1 of 3 metropolitan Washington, DC, USA, hospitals. Of breast-fed neonates 37% were given supplementary formula in the hospital. Mothers who gave birth at a university hospital were more likely to breast-feed exclusively (adjusted odds ratio 3.5; 95% confidence limit 2.1 to 5.9), after adjustment for maternal demographics, hospital factors and the maternal breast-feeding commitment. Aside from delivery hospital, a strong predictor of formula use was the time between birth and initiation of the first breast-feed. The longer a mother waited to initiate breast-feeding the more likely she was to use formula; the adjusted odds ratios for women who initiated breast-feeding 2 to 6 h, 7 to 11 h, and 12 or more h post partum were 1.1, 0.5, and 0.2, respectively. Feeding the baby on demand, having a vaginal delivery, deciding to breast-feed before pregnancy, having a college education and being married also were moderately, though significantly, predictive of exclusive breast-feeding. The findings suggest that hospital influences can promote formula use and indirectly shorten breast-feeding duration, particularly those hospital practices that delay early initiation of breast-feeding.
KW  - breast feeding
KW  - Cows
KW  - Infant feeding
KW  - infant formulae
KW  - infants
KW  - supplementary feeding
KW  - supplements
KW  - USA
KW  - cattle
KW  - Man
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - infant formula
KW  - infant formulas
KW  - United States of America
KW  - Animal Nutrition (General) (LL500) 
KW  - Diet Studies (VV110) 
KW  - Milk and Dairy Produce (QQ010) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Malaria parasite chitinase and penetration of the mosquito peritrophic membrane.
AU  - Huber, M.
AU  - Cabib, E.
AU  - Miller, L. H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1991///
VL  - 88
IS  - 7
SP  - 2807
EP  - 2810
SN  - 0027-8424
AD  - Huber, M.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920506418.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 1398-61-4, 9001-06-3.  Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Malaria parasites (ookinetes) appear to digest the peritrophic membrane in the mosquito midgut during penetration. Previous studies demonstrated that lectins specific for N-acetylglucosamine bind to the peritrophic membrane and proposed that the membrane contains chitin [see W. Rudin & H. Hecker (1989) Parasitology Research, 75: 268-279]. In the present study, it was shown that the peritrophic membrane of Aedes aegypti (Liverpool/black eye strain) is digested by Serratia marcescens chitinase (EC 3.2.1.14), leading to the release of N-acetylglucosamine and fragmentation of the membrane. The presence is also reported of a malaria parasite chitinase that digests 4-methylumbelliferyl chitotriose. The enzyme is not detectable until 15 h after zygote formation, the time required for maturation of the parasite (Plasmodium gallinaceum 8A strain) from a zygote to an ookinete, the invasive form of the parasite. At 20 h, the enzyme begins to appear in the culture supernatant. The chitinase extracted from the parasite and found in the culture supernatant consists of a major band and 2 minor bands of activity on native polyacrylamide gel electrophoresis. The presence of chitin in the peritrophic membrane, the disruption of the peritrophic membrane during invasion, and the presence of chitinase in ookinetes suggest that the chitinase in ookinetes is used in the penetration of the peritrophic membrane.
KW  - Chitin
KW  - Chitinase
KW  - disease vectors
KW  - Enzymes
KW  - host parasite relationships
KW  - infections
KW  - Ookinetes
KW  - parasites
KW  - Peritrophic membrane
KW  - Vectors
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - parasite host relationships
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infectious RNA transcribed from stable cloned full-length cDNA of dengue type 4 virus.
AU  - Lai, C. J.
AU  - Zhao, B.
AU  - Hori, H.
AU  - Bray, M.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1991///
VL  - 88
IS  - 12
SP  - 5139
EP  - 5143
SN  - 0027-8424
AD  - Lai, C. J.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920506837.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9007-49-2, 63231-63-0.  Subject Subsets: Medical & Veterinary Entomology
N2  - Successful cloning is described of a stable full-length cDNA copy of dengue type 4 virus that can be used as the template for in vitro transcription of infectious RNA. Evidence is presented that dengue virus recovered from permissive cells transfected with the in vitro RNA transcripts retained a mutation that was engineered into full-length cDNA. The properties of the virus produced by cells transfected with infectious RNA transcripts of dengue cDNA resembled those of the virus from which the cDNA clone was derived. The dengue virus recombinant DNA system should prove helpful in gaining a better understanding of the molecular biology of dengue viruses and should facilitate the development of a safe and effective live vaccine for use in humans.
KW  - Arboviruses
KW  - DNA
KW  - Molecular genetics
KW  - RNA
KW  - transcription
KW  - Dengue virus
KW  - Flaviviridae
KW  - Flavivirus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - ribonucleic acid
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a programmed alteration in an 18S ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni.
AU  - Brindley, P. J.
AU  - Heath, S.
AU  - Waters, A. P.
AU  - McCutchan, T. F.
AU  - Sher, A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1991///
VL  - 88
IS  - 17
SP  - 7754
EP  - 7758
SN  - 0027-8424
AD  - Brindley, P. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878570.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 3105-97-3.  Subject Subsets: Helminthology
N2  - Stable resistance to hycanthone can be produced in S. mansoni by exposing immature parasites in mice to the drug. Within a single generation, genomic rearrangements, detected as rRNA-encoding DNA restriction fragment length polymorphisms (RFLPs), accompany the appearance of resistance in this model. One of these RFLPs, an ~3.6-kilobase BamHI fragment, has been shown previously to associate consistently with resistance in independent generations of the JHU strain of S. mansoni. To characterize the genetic changes responsible for this RFLP, the fragment was cloned and sequenced. A comparison of the cloned fragment with a normal 18S rRNA gene demonstrated that the drug resistance-associated RFLP fragment arises through the addition of 732 base pairs into an 18S rRNA gene, 134 base pairs downstream of the junction of the intergenic spacer and the mature 18S rRNA gene. The mutation is nonrandom, targets one, or a few only, of the 100 or so copies of the ribosomal genes, and may represent the incomplete duplication of the gene since the inserted element is identical in sequence to the region contiguous to it. The sequence spanning the junction of the insertion and the original 18S rRNA gene was used as a specific primer for the BamHI RFLP in PCR experiments. The analysis conclusively demonstrated that the mutation is induced rather than selected by the drug since the junctional sequence was not detectable in the drug-sensitive parent population of schistosomes. In addition, analysis of 4, independently derived, resistant lines indicated that the same region of the gene was mutated each time. Together, these data demonstrate that reproducible changes are induced during the acquisition of resistance in schistosomes and suggest that the resistant phenotype is induced rather than selected from preexisting forms.
KW  - drug resistance
KW  - Genes
KW  - helminths
KW  - Human diseases
KW  - hycanthone
KW  - Molecular genetics
KW  - parasites
KW  - Resistance mechanisms
KW  - Restriction fragment length polymorphism
KW  - Digenea
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - biochemical genetics
KW  - parasitic worms
KW  - RFLP
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The era of aerosol pentamidine prophylaxis: the beginning or the end.
AU  - Falloon, J.
AU  - Masur, H.
T2  - American Journal of Medicine
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991///
VL  - 90
IS  - 4
SP  - 415
EP  - 417
SN  - 0002-9343
AD  - Falloon, J.: Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19930883110.  Publication Type: Editorial.  Language: English.  Number of References: 10 ref. Registry Number: 100-33-4, 140-64-7.  Subject Subsets: Protozoology
N2  - This editorial looks at the history of aerosolized pentamidine as prophylaxis for Pneumocystis carinii pneumonia in immunocompromised patients from the first trial to the present day. Published studies suggest that both the original Respirgard and the newer Fisons ultrasonic nebulisers can be used to effectively decrease the relapse rate of P. carinii pneumonia. It is now suggested that a direct trial comparing the performance of the two nebuliser systems is needed to compare performance.
KW  - aerosols
KW  - antiprotozoal agents
KW  - human diseases
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pentamidine
KW  - prophylaxis
KW  - respiratory diseases
KW  - reviews
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - fungus
KW  - lung diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Carcinogenesis studies in rodents for evaluating risks associated with chemical carcinogens in aquatic food animals.
AU  - Huff, J.
AU  - Bucher, J.
AU  - Yang, R.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1991///
VL  - 90
SP  - 127
EP  - 132
SN  - 0091-6765
AD  - Huff, J.: National Institute of Environmental health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19931459117.  Publication Type: Journal Article.  Language: English.  Number of References: 101 ref. Subject Subsets: Human Nutrition
N2  - Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor, Massachusetts, USA, was found to have visible liver neoplasms; winter flounder outside the estuary area had no liver lesions. Long-term chemical carcinogenesis studies could be easily and feasibly designed using laboratory rodents offered diets containing fish caught in polluted waters. Induced neoplasms in rodents would corroborate field observations in fish; positive results from these studies would provide further evidence about potential human health hazards from eating substantial amounts of chemically contaminated fish. Nonetheless, fish and aquatic organisms should be viewed as environmental biological monitors of pollution or of potential human health hazards, and authorities responsible for assuring clean and safe rivers, bodies of water and biota should give more attention to these valid biological indicators or sentinels of environmental pollution. Consequently, fish and other sea creatures alone should serve as alarms regarding whether water areas constitute public health hazards.
KW  - carcinogenesis
KW  - carcinogens
KW  - Pollution
KW  - risk
KW  - Seafoods
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - environmental pollution
KW  - Pollution and Degradation (PP600) 
KW  - Aquatic Produce (QQ060) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increasing use of soy foods and their potential role in cancer prevention.
AU  - Messina, M.
AU  - Messina, V.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1991///
VL  - 91
IS  - 7
SP  - 836
EP  - 840
SN  - 0002-8223
AD  - Messina, M.: Diet and Cancer Branch, Division of Cancer Prevention & Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920751443.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Subject Subsets: Soyabeans; Human Nutrition
N2  - The possible role of soyabeans in cancer prevention is discussed. Diets composed of 5% (wt./wt.) soyabeans significantly inhibited induced mammary cancer in rats; this is thought to be due to anticarcinogenic compounds, isoflavones, contained in appreciable amounts in soyabeans. Protease inhibitors are identified as preventing promotion of experimentally induced breast and colon cancer. Specific protease inhibitors contained in soyabeans are discussed. Results of epidemiological studies are reviewed and the increasing consumption of traditional soya foods (tofu, soya milk) and second-generation soya foods is highlighted.
KW  - Carcinoma
KW  - diet treatment
KW  - neoplasms
KW  - prevention
KW  - proteinase inhibitors
KW  - reviews
KW  - Soyabean products
KW  - soyabeans
KW  - Glycine (Fabaceae)
KW  - Man
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - cancers
KW  - diet prescription
KW  - protease inhibitors
KW  - soybean products
KW  - soybeans
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Crop Produce (QQ050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Healthy people 2000: development of nutrition objectives.
AU  - Danford, D. E.
AU  - Stephenson, M. G.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1991///
VL  - 91
IS  - 12
SP  - 1517
EP  - 1519
SN  - 0002-8223
AD  - Danford, D. E.: Division of Nutrition Research Coordination, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931459572.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition
N2  - The Healthy People 2000 report sets national objectives in health promotion and disease prevention for the year 2000. The dietetic profession must strive to achieve goals for improved public health, especially nutritionally related ones. Through planned implementation of these developments into dietitian programmes health objectives can be achieved by the end of the decade and the role of dietitian in applying nutrition can be expanded.
KW  - dietitians
KW  - Nutrition programmes
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - feeding programmes
KW  - feeding programs
KW  - food programs
KW  - nutrition programs
KW  - United States of America
KW  - Animal Nutrition (Production Responses) (LL520) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Late recurrent Candida endocarditis.
AU  - Johnston, P. G.
AU  - Lee, J.
AU  - Domanski, M.
AU  - Dressler, F.
AU  - Tucker, E.
AU  - Rothenberg, M.
AU  - Cunnion, R. E.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Chest
JF  - Chest
Y1  - 1991///
VL  - 99
IS  - 6
SP  - 1531
EP  - 1533
SN  - 0012-3692
AD  - Johnston, P. G.: T. J. Walsh, Pediatric Branch, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911210402.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 31-yr-old man in whom late recurrent C. albicans endocarditis (LRCE) developed on a prosthetic mitral valve 22 months after treatment for primary native mitral valve endocarditis. The LRCE was difficult to diagnose; results of 2 dimensional echocardiography and repeated blood cultures were negative. Only transoesophageal echocardiography revealed a vegetation and only lysis centrifugation blood cultures demonstrated candidaemia. Postmortem examination revealed a large Candida vegetation of the prosthetic valve, Candida in the mitral valve ring and fungal lesions in the liver, spleen and kidneys. A review of previously reported cases of LRCE indicated that Candida endocarditis treated with amphotericin B and prosthetic valve replacement may recur months after treatment, and that LRCE, which is difficult to diagnose and treat, may be best prevented by lifelong antifungal suppressive therapy.
KW  - generalized infections
KW  - heart
KW  - hosts
KW  - infections
KW  - predisposition
KW  - prostheses
KW  - USA
KW  - Candida albicans
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fungus
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Cerebral malaria: the unsolved riddle.
AU  - Román, G. C.
T2  - Journal of the Neurological Sciences
JO  - Journal of the Neurological Sciences
JF  - Journal of the Neurological Sciences
Y1  - 1991///
VL  - 101
IS  - 1
SP  - 1
EP  - 6
SN  - 0022-510X
AD  - Román, G. C.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808639.  Publication Type: Editorial.  Language: English.  Number of References: 49 ref.
KW  - Cerebral malaria
KW  - Pathogenicity
KW  - Pathology
KW  - Reviews
KW  - Apicomplexa
KW  - Man
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Neuropathology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808639&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cockroaches (Blatta and Periplaneta species) as reservoirs of drug-resistant salmonellas.
AU  - Devi, S. J. N.
AU  - Murray, C. J.
JO  - Epidemiology and Infection
JF  - Epidemiology and Infection
Y1  - 1991///
VL  - 107
IS  - 2
SP  - 357
EP  - 361
SN  - 0950-2688
AD  - Devi, S. J. N.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920511923.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A total of 221 cockroaches (Blatta and Periplaneta spp. [not identified to species]) collected in hospitals, houses, animal sheds, grocery stores and restaurants in various parts of South Kanara District, Karnataka, India, were studied bacteriologically for the presence of salmonellas. Salmonellas were isolated from 4.1% of these cockroaches. 9 strains of salmonellas were recovered, belonging to 5 serotypes: Salmonella bovismorbificans, S. oslo, S. typhimurium, S. mbandaka and S. braenderup, the former 2 being the commonest serotypes. All salmonellas were resistant to one or other of 11 antibacterial drugs used in a susceptibility test. Isolation of salmonellas from cockroaches collected from livestock premises and human dwellings suggested that they may act as significant reservoirs of Salmonella in nature. Recovery of serotypes, phage types and R-types that were commonly isolated from humans and animals in the area [see also Arogya Journal of Health Sciences, 15: 80-84 (1989) and Indian Journal of Medical Sciences, 40: 177-178 (1986)] suggested a transmission role for cockroaches. By harbouring potentially pathogenic, drug-resistant salmonellas, these wandering arthropods may pose dangerous infective hazards to humans and animals.
KW  - Animal housing
KW  - Antibiotics
KW  - buildings
KW  - Cattle housing
KW  - Disease vectors
KW  - Drug resistance
KW  - Hospitals
KW  - Livestock
KW  - mechanical transmission
KW  - Restaurants
KW  - Asia
KW  - India
KW  - Karnataka
KW  - Bacteria
KW  - Blatta orientalis
KW  - Blattaria
KW  - Blattidae
KW  - Dictyoptera
KW  - Enterobacteriaceae
KW  - Periplaneta americana
KW  - Salmonella
KW  - Salmonella typhimurium
KW  - prokaryotes
KW  - Blatta
KW  - Blattidae
KW  - Blattaria
KW  - Dictyoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - Periplaneta
KW  - Enterobacteriaceae
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - American cockroach
KW  - bacterium
KW  - Blattodea
KW  - cattle sheds
KW  - Mysore
KW  - Oriental cockroach
KW  - Salmonella bovismorbificans
KW  - Salmonella braenderup
KW  - Salmonella mbandaka
KW  - Salmonella oslo
KW  - Animal Husbandry (General) (LL100) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - National education programs working group report on the management of patients with hypertension and high blood cholesterol.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1991///
VL  - 114
IS  - 3
SP  - 224
EP  - 237
SN  - 0003-4819
AD  - E. J. Rocella, National Heart, Lung and Blood Institute, Building 31, Room 4A05, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911438163.  Publication Type: Journal Article.  Corporate Author: USA, Working Group on Management of Patients with Hypertension and High Blood Cholesterol Language: English.  Number of References: 89 ref. Subject Subsets: Human Nutrition
N2  - This position paper addresses prevention of morbidity and mortality from cardiovascular disease. It provides clinicians (and programmes) with an integrated approach to identification and management of patients with several cardiovascular risk factors, emphasizing hypertension and high blood cholesterol. Non-pharmacologic therapy, in the form of a proper diet, exercise, and smoking cessation, is recognized as the foundation for management of both hypertension and high blood cholesterol. It is suggested that clinicians should use these non-drug measures as definitive or adjunctive therapy. Pharmacologic agents have been found to be very beneficial in managing the risks imposed by high levels of blood pressure or blood cholesterol. In selecting medications, their benefits, costs, and potential untoward effects should be considered. Advice is given that clinicians consider these issues in managing patients with several risk factors. Potential for adverse effects should not preclude dismissing any particular mode of therapy or managing any risk factor.
KW  - cardiovascular diseases
KW  - diet treatment
KW  - Hypercholesterolaemia
KW  - Hypertension
KW  - prevention
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - diet prescription
KW  - high blood pressure
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911438163&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cardiopulmonary toxicity after liposomal amphotericin B infusion.
AU  - Levine, S. J.
AU  - Walsh, T. J.
AU  - Martinez, A.
AU  - Eichacker, P. Q.
AU  - Lopez-Berestein, G.
AU  - Natanson, C.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1991///
VL  - 114
IS  - 8
SP  - 664
EP  - 666
SN  - 0003-4819
AD  - Levine, S. J.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911208946.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - A case is reported in a 22-yr-old woman receiving high dose (5 mg/kg daily) liposomal amphotericin B (L-AmpB) for hepatosplenic Candida infection who developed reversible abnormalities in pulmonary gas exchange and cardiopulmonary haemodynamics.
KW  - administration
KW  - amphotericin B
KW  - Antifungal agents
KW  - candidosis
KW  - hosts
KW  - infections
KW  - liposomes
KW  - liver
KW  - spleen
KW  - therapy
KW  - toxicity
KW  - treatment
KW  - USA
KW  - Candida
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - amphotercin B
KW  - candidiasis
KW  - cardiopulmonary
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - reactions
KW  - therapeutics
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunolocalization of myosin I heavy chain kinase in Acanthamoeba castellanii and binding of purified kinase to isolated plasma membranes.
AU  - Kulesza-Lipka, D.
AU  - Baines, I. C.
AU  - Brzeska, H.
AU  - Korn, E. D.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1991///
VL  - 115
IS  - 1
SP  - 109
EP  - 119
SN  - 0021-9525
AD  - Kulesza-Lipka, D.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910875850.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activities of Acanthamoeba myosins I are known to be maximally expressed only when a single threonine (myosin IA) or serine (myosins IB and IC) is phosphorylated by myosin I heavy chain kinase. The purified kinase is highly activated by autophosphorylation and the rate of autophosphorylation is greatly enhanced by the presence of acidic phospholipids. It was shown by immunofluorescence and immunoelectron microscopy of permeabilized cells that myosin I heavy chain kinase is highly concentrated, but not exclusively, at the plasma membrane. Judged by their electrophoretic mobilities, kinase associated with purified plasma membranes may differ from the cytoplasmic kinase, possibly in the extent of its phosphorylation. Purified kinase binds to highly purified plasma membranes with an apparent KD of ~17 nM and a capacity of ~0.8 nmol/mg of plasma membrane protein, values that are similar to the affinity and capacity of plasma membranes for myosins I. Binding of kinase to membranes is inhibited by elevated ionic strength and by extensive autophosphorylation but not by substrate-level concentrations of ATP. Membrane-bound kinase autophosphorylates to a lesser extent than free kinase and does not dissociate from the membranes after autophosphorylation. The co-localization of myosin I heavy chain kinase and myosin I at the plasma membrane is of interest in relation to the possible functions of myosin I especially as phospholipids increase kinase activity.
KW  - Biochemistry
KW  - enzymes
KW  - Human diseases
KW  - Kinases
KW  - Membranes
KW  - myosins
KW  - parasites
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The child with cancer and infection. II. Nonbacterial infections.
AU  - Pizzo, P. A.
AU  - Rubin, M.
AU  - Freifeld, A.
AU  - Walsh, T. J.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1991///
VL  - 119
IS  - 6
SP  - 845
EP  - 857
SN  - 0022-3476
AD  - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211568.  Publication Type: Journal Article.  Language: English.  Number of References: 105 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The advances and the problems that relate to the diagnosis and treatment of infectious complications in paediatric cancer patients are reviewed. Invasive fungal infections, including oropharyngeal, oesophageal and hepatosplenic infections and fungaemia due to Candida, and infections caused by Aspergillus, Cryptococcus neoformans, Trichosporon, agents of mucormycosis, Pseudallescheria boydii, Fusarium and dematiaceous fungi, viruses and Pneumocystis carinii are discussed.
KW  - Antifungal agents
KW  - blood
KW  - children
KW  - infections
KW  - liver
KW  - mouth
KW  - neoplasms
KW  - oesophagus
KW  - pharynx
KW  - predisposition
KW  - spleen
KW  - therapy
KW  - ZYGOMYCOSIS
KW  - Aspergillus
KW  - Candida
KW  - Cryptococcus neoformans
KW  - Fusarium
KW  - man
KW  - Pseudallescheria boydii
KW  - Trichosporon
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporonaceae
KW  - cancers
KW  - esophagus
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - phycomycosis
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Pneumocystis carinii pneumonia despite prophylaxis in children with human immunodeficiency virus infection.
AU  - Mueller, B. U.
AU  - Butler, K. M.
AU  - Husson, R. N.
AU  - Pizzo, P. A.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1991///
VL  - 119
IS  - 6
SP  - 992
EP  - 994
SN  - 0022-3476
AD  - Mueller, B. U.: P.A. Pizzo, Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920881470.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 100-33-4, 140-64-7.  Subject Subsets: Protozoology
N2  - Six children with HIV infection are reported who developed Pneumocystis carinii pneumonia (PCP) while receiving prophylaxis. The prophylaxis was either pentamidine (intravenous or aerosolized) or trimethoprim/sulfamethoxazole. This study suggests that although reports support the efficacy of TMP/SMX prophylaxis with virtually no occurrences of PCP, clinicians taking care of a child with an HIV infection who has respiratory symptoms must maintain a high index of suspicion for the possibility of PCP, even if the child is receiving prophylaxis.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antiprotozoal agents
KW  - case reports
KW  - children
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pentamidine
KW  - prophylaxis
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - trimethoprim sulfamethoxazole
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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ER  - 

TY  - JOUR
T1  - Estimating the relation between dietary intake obtained from a food frequency questionnaire and true average intake.
AU  - Freedman, L. S.
AU  - Carroll, R. J.
AU  - Wax, Y.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1991///
VL  - 134
IS  - 3
SP  - 310
EP  - 320
SN  - 0002-9262
AD  - Freedman, L. S.: Biometry Branch, DCPC, National Cancer Institute, Executive Plaza North, Suite 344, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911439183.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Human Nutrition
N2  - Knowledge of the regression relation between dietary intake reported on a food frequency questionnaire and true average intake is useful in interpreting results from nutritional epidemiologic studies and in planning such studies. Studies which validate a questionnaire against a food record may be used to estimate this regression relation provided the food record is completed by each subject on at least 2 occasions. Using data collected from women 45-69 years old during 1985-1986 in the pilot study of the Women's Health Trial, it is shown how variation in diet over time and intraindividual correlation between a questionnaire and food record obtained close together in time affects the estimation of the regression. The method presented provides estimates of the regresssion slope and the questionnaire "bias" that are corrected for these effects, together with standard errors. A computer programme in the SAS language, for carrying out the analysis, is provided.
KW  - estimation
KW  - Food intake
KW  - questionnaires
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911439183&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A case-control study of nutrient status and invasive cervical cancer. 2. Serologic indicators.
AU  - Potischman, N.
AU  - Herrero, R.
AU  - Brinton, L. A.
AU  - Reeves, W. C.
AU  - Stacewicz-Sapuntzakis, M.
AU  - Jones, C. J.
AU  - Brenes, M. M.
AU  - Tenorio, F.
AU  - Britton, R. C. de
AU  - Gaitan, E.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1991///
VL  - 134
IS  - 11
SP  - 1347
EP  - 1355
SN  - 0002-9262
AD  - Potischman, N.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921443982.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - To investigate the hypothesis that lower serum values of 8 micronutrients were associated with a higher risk of invasive cervical cancer, 387 patients and 670 controls from 4 Latin American countries were studied. Serologic analyses were restricted to a sample of subjects with stage I and stage II disease to minimise effects of the disease on the serologic markers. 94% of eligible subjects donated blood samples, which were analysed for carotenoids, retinol and tocopherols by high-pressure liquid chromatography. Cases did not differ significantly from controls in mean serum concentrations of retinol, cryptoxanthin, lycopene, α-carotene, lutein, or α-tocopherol. Mean β-carotene was lower and mean γ-tocopherol was higher among cases compared with controls. After adjustment for age, study site, sexual and reproductive behaviour, socioeconomic status, screening practices, detection of human papillomavirus types 16/18, cholesterol, and triacylglycerols, a trend of decreasing risk was associated with higher β-carotene values (P for trend = 0.05), with the adjusted odds ratio decreasing to 0.72 for the highest versus the lowest quartile. β-Carotene results were similar by stage of disease, which argues against an effect of disease progression on nutrient values. Unexpectedly, increasing risks were observed as the concentration of γ-tocopherol increased (odds ratio = 2.09; P for trend = 0.03); however, values were higher among stage II cases compared with stage I cases, suggesting a metabolic alteration resulting from the disease process. The results support a role for β-carotene or foods rich in β-carotene in the aetiology of cervical cancer and indicate that simultaneous analysis using serologic and dietary nutrient indicators allows better discrimination of the association.
KW  - Carcinoma
KW  - carotenoids
KW  - cervix
KW  - nutritional state
KW  - retinol
KW  - tocopherols
KW  - Latin America
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - axerophthol
KW  - nutritional status
KW  - tetraterpenoids
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of aerosolized pentamidine prophylaxis on the diagnosis of Pneumocystis carinii pneumonia by induced sputum examination in patients infected with the human immunodeficiency virus.
AU  - Levine, S. J.
AU  - Masur, H.
AU  - Gill, V. J.
AU  - Feuerstein, I.
AU  - Suffredini, A. F.
AU  - Brown, D.
AU  - Lane, H. C.
AU  - Yarchoan, R.
AU  - Shelhamer, J. H.
AU  - Ognibene, F. P.
AU  - Ognibene, F. P.
JO  - American Review of Respiratory Disease
JF  - American Review of Respiratory Disease
Y1  - 1991///
VL  - 144
IS  - 4
SP  - 760
EP  - 764
SN  - 0003-0805
AD  - Levine, S. J.: F.P. Ognibene, Critical Care Medicine Department, Building 10, Room 7-D43, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920876102.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 100-33-4, 140-64-7.  Subject Subsets: Protozoology
N2  - The effect of aerosolized pentamidine prophylaxis on the clinical presentation and diagnostic sensitivity of induced sputum examination for P. carinii pneumonia PCP. Between January 1988 and October 1990, 348 induced sputum examinations were performed as the initial diagnostic procedure for PCP in HIV positive patients at the NIH, Maryland, USA. Medical records were reviewed for all induced sputum examinations, and the study group consisted of patients who either had not received prophylactic therapy (n = 193) or had received aerosolized pentamidine prophylaxis (n = 126). A total of 29 induced sputum examinations in patients receiving other prophylactic regimens or ongoing therapy for previously documented PCP were excluded from the study group. A total of 72 consecutive episodes of PCP were subsequently documented by induced sputum examination (n = 54), bronchoalveolar lavage (n = 16), thoracocentesis (n = 1), or autopsy (n = 1). A total of 44 episodes occurred in patients who had not received antipneumocystis prophylaxis, and 28 episodes occurred in patients who had received aerosolized pentamidine. Of patients capable of producing a sputum specimen for analysis, induced sputum examination had a significantly lower diagnostic yield of 64.3% in patients who had received aerosolized pentamidine prophylaxis compared with 92.3% in patients who did not receive prophylaxis. When the data were analyzed on an intention to treat basis, although there was a trend suggesting a lower overall yield in the aerosolized pentamidine-treated patients, the difference was not statistically significant (64.3 versus 81.8%). There was no significant difference in duration of symptoms, alveolar-arterial oxygen gradient, presenting radiographic manifestations, or burden of organisms (in patients with positive induced sputum examinations) between the 2 groups. However, there was a trend toward an increased incidence of focal upper lobe infiltrates in the aerosolized pentamidine group. It is concluded that aerosolized pentamidine prophylaxis is associated with a significantly lower diagnostic yield (64.3%) of induced sputum examination for PCP in HIV-infected patients if a specimen is obtained for analysis. Nevertheless, its yield is high enough such that an induced sputum examination should still be considered the initial diagnostic procedure for suspected PCP in these patients.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - aerosols
KW  - Antiprotozoal agents
KW  - clinical aspects
KW  - diagnosis
KW  - HIV infections
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - Pentamidine
KW  - Pneumocystis carinii pneumonia
KW  - prophylaxis
KW  - Sputum
KW  - Maryland
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Sensitivity
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.
AU  - Grzych, J. M.
AU  - Pearce, E.
AU  - Cheever, A.
AU  - Caulada, Z. A.
AU  - Caspar, P.
AU  - Heiny, S.
AU  - Lewis, F.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1991///
VL  - 146
IS  - 4
SP  - 1322
EP  - 1327
SN  - 0022-1767
AD  - Grzych, J. M.: A Sher, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910873178.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1.  Subject Subsets: Helminthology
N2  - To characterize Th cell populations induced by helminth infection, spleen cells from C3H/HeN mice infected with Schistosoma mansoni (NMRI strain) were stimulated with parasite (worm or ovum antigen) or mitogen (Con A) and the supernatants assayed for the Th1-specific cytokines IFN-γ and IL-2 and the Th2-specific cytokines IL-4 and IL-5. Th2 cytokine production was not detected in substantial quantity until the 6th to 8th week of infection and after reaching peak levels at 8 to 12 weeks declined slowly thereafter. The time courses of IL-4 and IL-5 production, although differing from each other, closely resembled corresponding published data on IgE and peripheral blood eosinophil levels during murine schistosome infection. In contrast, Th1 cytokine responses occurred only during the first 6 weeks of infection and were virtually absent during the peak period of Th2 production. To assess the role of ovum deposition in the observed pattern of Th response, cytokine production was assayed in mice carrying unisexual schistosome infections in which parasite ova are absent. Splenocytes from these animals displayed only marginal Th2 cytokine synthesis but greater Th1 cytokine responses than the corresponding cells from mice with bisexual infections. Moreover, cultures of liver tissue or isolated granulomata from infected mice constitutively produced high levels of IL-4 and IL-5 but failed to synthesize significant amounts of IL-2 and IFN-γ even when stimulated with ovum antigen or mitogen. Taken together the data indicate that ova deposition is the major stimulus of Th2 cytokine response in S. mansoni-infected mice and suggest that T cells belonging to this subset play a major role in egg granuloma formation.
KW  - Cytokines
KW  - Developmental stages
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - interferon
KW  - interleukins
KW  - Laboratory animals
KW  - ova
KW  - parasites
KW  - Digenea
KW  - mice
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - growth phase
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels.
AU  - King, C. L.
AU  - Poindexter, R. W.
AU  - Ragunathan, J.
AU  - Fleisher, T. A.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1991///
VL  - 146
IS  - 5
SP  - 1478
EP  - 1483
SN  - 0022-1767
AD  - King, C. L.: Laboratory of Parasitic Diseases, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874091.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 37341-29-0.  Subject Subsets: Helminthology
N2  - The immunoregulatory mechanisms that determine the high serum IgE antibody levels in disorders such as helminth parasite infections and the hyper-IgE recurrent infection syndrome (HIE) remain poorly understood. To assess whether elevated serum IgE levels result from an increased number of B lymphocytes committed to IgE production, the proportion of IgE-producing B lymphocytes was determined by a filter immunoplaque assay using peripheral blood mononuclear cells (PBMC) from persons with a broad range of serum IgE levels that included normal persons (n = 9) and patients with loiasis (n =12), tropical pulmonary eosinophilia (TPE) (n = 6), lymphatic filariasis caused by Wuchereria bancrofti (n = 28), and hyper-IgE recurrent infection syndrome (HIE, n = 8). PBMC from these persons were assessed for production of in vitro IgE. The geometric mean number of IgE-secreting cells in 105 B lymphocytes in PBMC was 0.42 (range 0-2.2) in normal persons, 5.6 (range 0.1-35.5) among patients with loiasis, 9.4 (range 0-53.2) among patients with lymphatic filariasis, 52 (range 31.5-115) among patients with TPE, and 218 (range 56-1404) among patients with HIE. When all study subjects were grouped, there were significant correlations with serum IgE levels and net spontaneous in vitro IgE production. Estimates of the amount of IgE production per B lymphocyte were similar among normal persons, patients with filarial infections, and patients with TPE (geometric means of 134, 96, and 141 pg/ml/cell, respectively); in contrast, for HIE patients, IgE production by individual B cells was significantly lower (geometric mean 28 pg/ml/cell). These observations demonstrate that clonal expansion of IgE-producing B lymphocytes is a major mechanism underlying the elevated serum IgE levels seen in persons with hyper-IgE states.
KW  - Antibodies
KW  - B lymphocytes
KW  - Filariasis
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - IgE
KW  - immune response
KW  - parasites
KW  - Loa loa
KW  - man
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Wuchereria
KW  - African eyeworm
KW  - B cells
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.
AU  - Sher, A.
AU  - Fiorentino, D.
AU  - Caspar, P.
AU  - Pearce, E.
AU  - Mosmann, T.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1991///
VL  - 147
IS  - 8
SP  - 2713
EP  - 2716
SN  - 0022-1767
AD  - Sher, A.: National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920876010.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Helminthology
N2  - After the onset of parasite egg deposition, mice infected with Schistosoma mansoni mount strong Th2 cytokine responses in the absence of significant Th1 cytokine synthesis. To examine the basis of this immunoregulatory state, spleen or lymph node cells from schistosome-infected mice were stimulated with parasite-specific antigen (Ag) and the supernatants tested for their capacity to suppress interferon (IFN-γ) synthesis by a Th1 cell line. Strong inhibition was observed that was neutralized by a MAb against IL-10, a cytokine previously shown to down-regulate Th1 cytokine synthesis. By means of ELISA measurements the production of IL-10 in schistosome infection was confirmed and shown to depend on CD4+ T cells. IL-10 synthesis stimulated by either mitogen or Ag was observed only at those stages of infection when Th2 response induction and Th1 cytokine down-regulation also occurred and was not detected in mice vaccinated with attenuated parasites. Moreover, the addition of the neutralizing anti-IL-10 MAb to Ag-stimulated spleen cell cultures from infected mice caused a dramatic augmentation in IFN-γ synthesis. These findings suggest that IL-10 is responsible for the down-regulation of Th1 responses observed in schistosome infections.
KW  - Cytokines
KW  - helminths
KW  - immune response
KW  - Interleukins
KW  - Laboratory animals
KW  - parasites
KW  - T lymphocytes
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of host cell-derived membrane proteins of the vacuole surrounding different intracellular forms of Trypanosoma cruzi in J774 cells.
AU  - Hall, B. F.
AU  - Furtado, G. C.
AU  - Joiner, K. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1991///
VL  - 147
IS  - 12
SP  - 4313
EP  - 4321
SN  - 0022-1767
AD  - Hall, B. F.: Parasitology and Tropical Medicine Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920877101.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Protozoology
N2  - T. cruzi exhibits developmental regulation of virulence. Although both noninfective epimastigote and infective trypomastigote stages of T. cruzi enter phagocytic cells via the formation of a parasitophorous vacuole (PV), only the latter developmental stages survive ingestion and perpetuate the infection. To determine whether the membrane composition of PV surrounding these different stages might contribute to differences in the outcome of infection, selected membrane constituents were identified by immunofluorescence and intracellular radioiodination, and their incorporation into PV was studied. Complement receptors (CR3) were incorporated preferentially into the PV membrane surrounding serum-opsonized epimastigotes but not culture-derived metacyclic trypomastigotes. FcR were not preferentially incorporated into PV membranes unless epimastigotes or culture-derived metacyclic trypomastigotes were opsonized with anti-T. cruzi antibody. PV surrounding either parasite stage contain β1 integrins and lysosomal membrane glycoproteins (lgp). These results indicate that the plasma membrane glycoproteins incorporated into the surrounding PV membrane differ depending upon the stage of parasite being internalized, and that these differences reflect, at least in part, selective ligation of cell surface receptors mediating uptake. Furthermore, they imply that although virulent trypomastigote stages may avoid host cell uptake by conventional phagocytic receptors, i.e., CR3 or FcR, they do not escape fusion with an lgp-containing vacuole where they could still be exposed to lysosomal antimicrobial mechanisms.
KW  - Cell invasion
KW  - Cell membranes
KW  - host parasite relationships
KW  - Human diseases
KW  - parasites
KW  - phagocytes
KW  - Vacuoles
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877101&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Change in cholesterol awareness and action. Results from national physician and public surveys.
AU  - Schucker, B.
AU  - Wittes, J. T.
AU  - Santanello, N. C.
AU  - Weber, S. J.
AU  - McGoldrick, D.
AU  - Donato, K.
AU  - Levy, A.
AU  - Rifkind, B. M.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1991///
VL  - 151
IS  - 4
SP  - 666
EP  - 673
SN  - 0003-9926
AD  - Schucker, B.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Room 401, Federal Bldg, 7550 Wisconsin Ave, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931467394.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 57-88-5. 
N2  - The National Heart, Lung, and Blood Institute, USA sponsored national telephone surveys of practising physicians and the adult public in 1983, 1986 and 1990 to assess attitudes and practices regarding high serum cholesterol values. Each time, about 1600 physicians and 4000 adults were interviewed. Trends show continuing change in medical practice and public health behaviour relating to serum cholesterol. In 1990, physicians reported treating serum cholesterol at considerably lower values than in 1986 and 1983. The median range of serum cholesterol at which diet therapy was initiated was 5.17-5.66 mmol/litre (200 to 219 mg/dl) in 1990, down from 6.21-6.70 mmol/litre (240 to 259 mg/dl) in 1986 and 6.72-7.21 mmol/litre (260 to 279 mg/dl) in 1983. The median ranges for initiating drug therapy were 6.21-6.70 mmol/litre (240 to 259 mg/dl) in 1990, 7.76-8.25 mmol/litre (300 to 319 mg/dl) in 1986, and 8.79-9.28 mmol/litre (340 to 359 mg/dl) in 1983. The number of adults who reported having had their cholesterol checked was 35, 46 and 65% in 1983, 1986 and 1990, respectively. Between 1983 and 1990, the number of adults reporting a physician diagnosis of high serum cholesterol increased from 7 to 16%; the number reporting a prescribed cholesterol-lowering diet increased from 3 to 9%. Reports of self-initiated diet efforts reached a high of 19% in 1986, and decreased to 15% in 1990. 2% of adults reported drug prescriptions in 1990 compared with 1% in earlier years. In 1990, over 90% of physicians reported awareness and use of the recommendations from the Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment for High Blood Cholesterol in Adults, and the public reported marked increases in awareness of dietary methods to lower serum cholesterol. These changes suggest educational gains; the data also suggest areas for continued cholesterol educational initiatives.
KW  - Blood
KW  - Cholesterol
KW  - Diet treatment
KW  - Drug therapy
KW  - Hypercholesterolaemia
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - diet prescription
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931467394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Amphotericin B vs high-dose ketoconazole for empirical antifungal therapy among febrile, granulocytopenic cancer patients. A prospective, randomized study.
AU  - Walsh, T. J.
AU  - Rubin, M.
AU  - Hathorn, J.
AU  - Gress, J.
AU  - Thaler, M.
AU  - Skelton, J.
AU  - McKnight, J.
AU  - Browne, M.
AU  - Marshall, D.
AU  - Cotton, D.
AU  - Hiemenz, J.
AU  - Longo, D.
AU  - Wesley, R.
AU  - Pizzo, P. A.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1991///
VL  - 151
IS  - 4
SP  - 765
EP  - 770
SN  - 0003-9926
AD  - Walsh, T. J.: Infectious Disease Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911209591.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 1397-89-3, 65277-42-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - High-dose ketoconazole (800 mg/kg daily, orally) was compared with amphotericin B (0.5 mg/kg daily, intravenously) for empirical antifungal therapy in a prospective, randomized study of persistently or recurrently febrile granulocytopenic cancer patients. Among 97 patients eligible for empirical antifungal therapy, 20 (21%) of these patients were ineligible for randomization to ketoconazole treatment because of their inability to tolerate oral medications. Among 72 patients eligible for randomization, 64 were assessable (32 in each arm of the study). Fungal infections were diagnosed in 10 of these 64 patients and in 2 of the 20 non-randomized patients. Candida albicans, C. tropicalis, Aspergillus, A. niger and A. flavus were the causative agents. Five of 6 patients with proved fungal infections who were randomized to receive ketoconazole treatment required crossover to amphotericin B treatment because of progressive infection. The conditions of 3 of these 5 patients improved after receiving amphotericin B. The frequency of transaminase elevation was higher in those receiving ketoconazole, while the frequency of azotaemia was higher in those receiving amphotericin B. Bioavailability of ketoconazole was unpredictable. It is concluded that amphotericin B remains the drug of choice for empirical antifungal therapy in granulocytopenic patients, whereas lack of a parenteral formulation, ineffectiveness against proved mycoses and unreliable bioavailability preclude high-dose ketoconazole from being an appropriate compound for this purpose.
KW  - amphotericin B
KW  - Antifungal agents
KW  - hosts
KW  - infections
KW  - ketoconazole
KW  - predisposition
KW  - therapy
KW  - USA
KW  - Aspergillus
KW  - Aspergillus flavus
KW  - Aspergillus niger
KW  - Candida albicans
KW  - Candida tropicalis
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Aspergillus
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - therapeutics
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209591&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - National Cholesterol Education Program. Report of the expert panel on population strategies for blood cholesterol reduction: executive summary.
A2  - Dalen, J. E.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1991///
VL  - 151
IS  - 6
SP  - 1071
EP  - 1084
SN  - 0003-9926
AD  - National Coordinator, National Cholesterol Education Program, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921445691.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The Population Panel of the National Cholesterol Education Program (NCEP) USA, gives a set of recommendations designed to help healthy Americans decrease blood cholesterol by changes in eating patterns. Recommendations are aimed at individuals, special groups, health professionals, the food industry and government agencies as well as public and private education systems.
KW  - blood
KW  - cholesterol
KW  - nutrition education
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Education, Extension, Information and Training (General) (CC000) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445691&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vivo interferon-γ therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae.
AU  - Rex, J. H.
AU  - Bennett, J. E.
AU  - Gallin, J. I.
AU  - Malech, H. L.
AU  - DeCarlo, E. S.
AU  - Melnick, D. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1991///
VL  - 163
IS  - 4
SP  - 849
EP  - 852
SN  - 0022-1899
AD  - Rex, J. H.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19911210536.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Registry Number: 9008-11-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - During a double-blind, placebo-controlled, randomized trial of recombinant interferon-γ (rIFN-γ) therapy in chronic granulomatous disease (CGD), a metabolic assay of neutrophil damage to A. fumigatus hyphae was used to monitor neutrophil function before and during therapy. In this assay, 5 × 104 conidia that had germinated into hyphae were exposed to 5 × 105, 15 × 105 or 50 × 105 CGD neutrophils. By analysis of variance, neutrophils from patients on rIFN-γ were found to produce significantly more damage to hyphae than those from the placebo group (P&lt;0.01). In subgroup analysis, this effect was best seen in the hyphae exposed to 50 × 105 CGD neutrophils, where neutrophils from patients receiving rIFN-γ produced significantly more damage to the hyphae than those from the placebo group (P&lt;0.05). It is concluded that in vivo rIFN-γ therapy improves the ability of CGD neutrophils to damage A. fumigatus hyphae in an in vitro assay.
KW  - immunology
KW  - interferon
KW  - neutrophils
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210536&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Polyamine metabolism in Pneumocystis carinii.
AU  - Lipschik, G. Y.
AU  - Masur, H.
AU  - Kovacs, J. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1991///
VL  - 163
IS  - 5
SP  - 1121
EP  - 1127
SN  - 0022-1899
AD  - Lipschik, G. Y.: Critical Care Medicine Department, National Institutes of Health, Bldg. 10, Room 10D48, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874229.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Subject Subsets: Protozoology
N2  - To investigate polyamine metabolism in P. carinii, extracts of the organism were analyzed for polyamine content and ornithine decarboxylase activity, and [³H]ornithine and [14C]arginine incorporation into polyamines during short-term culture was determined. P. carinii extracts contained putrescine and spermidine in a ratio of 0.17:1; traces of spermine were detected. Although ornithine decarboxylase activity was not detected, P. carinii incorporated ornithine and arginine into putrescine and spermidine but not into spermine, suggesting that the spermine detected derived from contaminating host cells. Uninfected rat lung incorporated ornithine minimally. Pentamidine α-difluoromethylornithine, and α-monofluoromethyldehydroornithine methyl ester inhibited ornithine incorporation by up to 86% at clinically achievable concentrations. These data provide a rationale for using polyamine synthesis antagonists in P. carinii pneumonia and a method for screening anti-Pneumocystis drugs in vitro.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - antiinfective agents
KW  - Antiprotozoal agents
KW  - Biochemistry
KW  - in vitro
KW  - metabolism
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - polyamines
KW  - Treatment
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - AIDS
KW  - antimicrobials
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - β1,4-Oligoglucosides inhibit the binding of Aspergillus fumigatus conidia to human monocytes.
AU  - Kan, V. L.
AU  - Bennett, J. E.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1991///
VL  - 163
IS  - 5
SP  - 1154
EP  - 1156
SN  - 0022-1899
AD  - Kan, V. L.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911210572.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The binding of A. fumigatus conidia to human monocytes was profoundly inhibited by a barley β-glucan. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1,3) and cellobiose (β1,4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1,4-linked glucose residues were more potent as specific inhibitors of this binding over similar concn. Increasing the number of β1,4-linked glucose residues led to greater inhibition of conidial binding by human monocytes.
KW  - binding
KW  - immunology
KW  - inhibition
KW  - monocytes
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210572&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection.
AU  - Markoff, L. J.
AU  - Innis, B. L.
AU  - Houghten, R.
AU  - Henchal, L. S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1991///
VL  - 164
IS  - 2
SP  - 294
EP  - 301
SN  - 0022-1899
AD  - Markoff, L. J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930517856.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 9001-91-6.  Subject Subsets: Medical & Veterinary Entomology
N2  - The 4 serotypes of dengue virus cause an acute febrile illness (dengue fever) or a more prolonged illness with plasma leakage resulting in hypovolaemia (dengue haemorrhagic fever). Haemorrhage may accompany either. Epidemiologic data suggest a role for dengue antibodies in pathogenesis. Computer analysis revealed a 20-residue region of similarity in amino acid sequence between the dengue type 4 envelope glycogen (E) and a family of clotting factors, including plasminogen, the prime mediator of fibrinolysis. By use of synthetic peptides in ELISA, E antibodies that potentially bind plasminogen were detected in 75% of 40 Thai patients acutely infected with dengue virus type 1, 2, 3 or 4. Plasminogen cross-reactivity of dengue antibodies was shown to be specific for the related sites in E and plasminogen. The dengue E sequence with similarity to plasminogen is largely conserved within the currently known flavivirus E sequences. However, 15 Thai patients hospitalized for illness caused by Japanese encephalitis virus (a flavivirus not associated with haemorrhage) did not develop plasminogen-cross-reactive antibodies, and this finding correlated with failure of Japanese encephalitis virus antibodies to bind to the plasminogen-cross-reactive site in E.
KW  - Antibodies
KW  - Arboviruses
KW  - Dengue
KW  - Human diseases
KW  - Immune response
KW  - Immunopathology
KW  - pathogenesis
KW  - Plasminogen
KW  - Viral diseases
KW  - Viral proteins
KW  - Thailand
KW  - Dengue virus
KW  - Flavivirus
KW  - Japanese encephalitis virus
KW  - man
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - arthropod-borne viruses
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - viral infections
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517856&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparative safety, tolerance, and pharmacokinetics of amphotericin B lipid complex and amphotericin B desoxycholate in healthy male volunteers.
AU  - Kan, V. L.
AU  - Bennett, J. E.
AU  - Amantea, M. A.
AU  - Smolskis, M. C.
AU  - McManus, E.
AU  - Grasela, D. M.
AU  - Sherman, J. W.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1991///
VL  - 164
IS  - 2
SP  - 418
EP  - 421
SN  - 0022-1899
AD  - Kan, V. L.: Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19911210513.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - Amphotericin B lipid complex (ABLC) and amphotericin B desoxycholate (AB, Fungizone) were compared for safety, tolerance and pharmacokinetics in 2 groups of 8 healthy male volunteers. After a 1-mg test dose, study drug was infused at 0.1, 0.25 and 0.5 mg/kg; the 0.5-mg/kg dose was not given to subjects receiving AB. ABLC caused few acute adverse effects except for mild somnolence in 6 volunteers. In addition, 3 of 8 ABLC recipients had asymptomatic, transient serum transaminase elevations that resolved spontaneously. The AB recipients experienced more acute side effects, but only 1 had a mild shaking chill; 3 of 8 also experienced sleepiness. No significant changes in vital signs, electrocardiograms, oximetry, pulmonary function or clinical status were observed in either group. Due to its increased estimated volume of distribution and estimated clearance, ABLC yielded decreased amphotericin B levels and area under the serum concentration versus time curve relative to AB.
KW  - administration
KW  - Amphotericin B
KW  - Antifungal agents
KW  - liposomes
KW  - pharmacokinetics
KW  - toxicity
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210513&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anemia and spontaneous preterm birth.
AU  - Klebanoff, M. A.
AU  - Shiono, P. H.
AU  - Selby, J. V.
AU  - Trachtenberg, A. I.
AU  - Graubard, B. I.
JO  - American Journal of Obstetrics and Gynecology
JF  - American Journal of Obstetrics and Gynecology
Y1  - 1991///
VL  - 164
IS  - 1Pt1
SP  - 59
EP  - 63
AD  - Klebanoff, M. A.: Division of Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, EPN 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911436313.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Human Nutrition
N2  - The association between anaemia during pregnancy and spontaneous preterm birth was studied using a large multiethnic cohort. Results of all haematological measurements were abstracted from prenatal and delivery records of 1706 of the 26 901 women. Among women who delivered infants at term, mean haematocrit value was low during the early phase of the second trimester, stable until near term, then reached a maximum at 40 weeks gestation. The mean haematocrit value of black women was lower than that of Asian, Mexican, and white women. Anaemia (haematocrit value less than the 10th percentile for ethnic group and duration of pregnancy) at any time during the second trimester was positively associated with subsequent spontaneous preterm birth (odds ratio, 1.9). Compared with white women, the odds ratio for preterm birth were 2.0 for black, 1.2 for Asian, and 1.2 for Mexican women. Adjustment for second-trimester anaemia had minimal influence on the odds ratios. It is suggested that anaemia during the second trimester was associated with preterm birth, but it does not account for the large ethnic differences in preterm birth.
KW  - anaemia
KW  - birth weight
KW  - ethnic groups
KW  - Pregnancy
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anemia
KW  - gestation
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.
AU  - Pearce, E. J.
AU  - Caspar, P.
AU  - Grzych, J. M.
AU  - Lewis, F. A.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1991///
VL  - 173
IS  - 1
SP  - 159
EP  - 166
SN  - 0022-1007
AD  - Pearce, E. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 9000 Rockville Rike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910875550.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9008-11-1.  Subject Subsets: Helminthology
N2  - Preliminary data showing enhanced interleukin-5 (IL-5) production by T cells from infected mice and interferon γ (IFN-γ) synthesis by cells from vaccinated animals, suggested differential CD4+ subset stimulation by the different parasite stimuli. To confirm this hypothesis, lymphocytes from vaccinated or S. mansoni infected animals were compared for their ability to produce IFN-γ and IL-2 (secreted by Th1 cells) as compared with IL-4 and IL-5 (characteristic Th2 cytokines). After stimulation with specific antigen or mitogen, T cells from vaccinated 6-8 week-old female C57BL/6 mice or prepatently infected animals responded primarily with Th1 lymphokines, whereas lymphocytes from patently infected mice instead produced Th2 cytokines. The Th2 response in infected animals was shown to be induced by schistosome eggs and directed largely against egg antigens, whereas the Th1 reactivity in vaccinated mice was triggered primarily by larval antigens. Th1 responses in mice carrying egg-producing infections were found to be profoundly downregulated. Moreover, the injection of eggs into vaccinated mice resulted in a reduction of antigen and mitogen-stimulated Th1 function accompanied by a coincident expression of Th2 responses. Together, the data suggest that coincident with the induction of Th2 responses, murine schistosome infection results in an inhibition of potentially protective Th1 function. This previously unrecognized downregulation of Th1 cytokine production may be an important immunological consequence of helminth infection related to host adaptation.
KW  - Cytokines
KW  - helminths
KW  - immune response
KW  - immunization
KW  - Interferon
KW  - Interleukins
KW  - Laboratory animals
KW  - Live vaccines
KW  - parasites
KW  - T lymphocytes
KW  - Vaccines
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - attenuated vaccines
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dengue virus premembrane and membrane proteins elicit a protective immune response.
AU  - Bray, M.
AU  - Lai ChingJuh
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1991///
VL  - 185
IS  - 1
SP  - 505
EP  - 508
SN  - 0042-6822
AD  - Bray, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950506368.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref.
N2  - Recombinant vaccinia viruses were expressed which express the premembrane (pre-M), membrane (M), or the cleaved, residual portion of pre-M (non-M) proteins of dengue 4 virus, or the pre-M, non-M, or envelope (E) proteins of dengue 2 virus, to evaluate their ability to induce protective immunity in mice. Cells infected with these recombinants make proteins of expected size. Mice immunized with recombinants expressing dengue 4 pre-M or M were protected against subsequent dengue 4 encephalitis challenge, but non-M was not protective. A recombinant which expressed dengue 2 E was partially protective against homotypic challenge, but dengue 2 pre-M was not protective. However, a recombinant which expressed both pre-M and E as a polyprotein gave solid protection, while the simultaneous administration of the 2 recombinants expressing pre-M and E gave a significant level of protection. Pre-M and M function as antigens eliciting a protective immune response, and the combination of pre-M plus E is more protective than E alone.
KW  - arboviruses
KW  - immunization
KW  - recombination
KW  - viral proteins
KW  - dengue 4 virus
KW  - dengue virus
KW  - mice
KW  - vaccinia virus
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - arthropod-borne viruses
KW  - genetic recombination
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506368&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High-performance liquid chromatography of lipids for the identification of human metabolic disease.
AU  - Markello, T. C.
AU  - Guo, J.
AU  - Gahl, W. A.
JO  - Analytical Biochemistry
JF  - Analytical Biochemistry
Y1  - 1991///
VL  - 198
IS  - 2
SP  - 368
EP  - 374
SN  - 0003-2697
AD  - Markello, T. C.: Section on Human Biochemical Genetics, Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19931461206.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Human Nutrition
N2  - A quantitative lipid analysis using ternary gradient high-performance liquid chromatography with evaporative light scattering detection is described. This technique was applied to extracts of cultured fibroblasts, cultured lymphocytes, and leukocytes and to liver and spleen biopsy specimens. Separation of nonpolar lipids, glycolipids, phospholipids, and sphingolipids was achieved in a single run. Detection did not depend on any specific chemical reactions, uv absorption, or fluorescence. Sensitivity is below 200 ng for individual lipids, and many individual lipid classes were detected in samples as small as 1 mg of total protein, the yield of a single flask of cultured skin fibroblasts. The characteristic stored lipids cholesterol ester and sphingomyelin were seen in excess in human fibroblast cultures from patients with Wolman's disease and Niemann-Pick disease, respectively. A biopsy spleen sample from a patient with Gaucher's disease had a large glucosyl-ceramide peak. It is concluded that this technique provides a tool for detecting lipids that accumulate in tissues of patients with currently unidentified metabolic storage disorders.
KW  - analytical methods
KW  - HPLC
KW  - Lipids
KW  - Metabolic disorders
KW  - tissues
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - high performance liquid chromatography
KW  - lipins
KW  - metabolic diseases
KW  - Techniques and Methodology (ZZ900) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ocular manifestations of AIDS.
AU  - Smet, M. D. de
AU  - Nussenblatt, R. B.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1991///
VL  - 226
IS  - 21
SP  - 3019
EP  - 3022
SN  - 0098-7484
AD  - Smet, M. D. de: National Eye Institute, National Institutes of Health, Building 10, Room 10N202, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879150.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology
N2  - Of 3 described cases of ocular manifestations in AIDS, one was suffering from Toxoplasma gondii infection. The 8-year-old girl, from Maryland, USA, presented for a routine examination when she was noted to have a peripheral white retinal scar with a central area of retinal and choroidal atrophy and no hyperpigmentation. Her visual acuity was 6/12 (20/40); 4 months later, she returned with an active infiltrate at the edge of the scar. A diagnosis of ocular toxoplasmosis was made, and she was started on a combination of pyrimethamine, sulfadiazine sodium, and leucovorin calcium. Within a month the lesion resolved and became pigmented. Two months later, she returned with counting-fingers vision in her left eye and a fresh new lesion had developed under her macula. Again she was treated with anti-toxoplasmosis medication to which she responded rapidly. She was then kept on pyrimethamine and had no recurrences for the following 18 months. Her vision in the left eye was 6/9 (20/30).
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Case reports
KW  - Children
KW  - Eyes
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - Toxoplasmosis
KW  - Maryland
KW  - North America
KW  - USA
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An immunogenic Onchocerca volvulus antigen: A specific and early marker of infection.
AU  - Lobos, E.
AU  - Weiss, N.
AU  - Karam, M.
AU  - Taylor, H. R.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1991///
VL  - 251
IS  - 5001
SP  - 1603
EP  - 1605
SN  - 0036-8075
AD  - Lobos, E.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808674.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - A complementary DNA fragment coding for an Onchocerca volvulus antigen (OV-16) was cloned and expressed in the plasmid vector pCG808fx. The purified OV-16 was used in an ELISA to analyze the antibody responses of 41 onchocerciasis patients (aged 3 to 60 years), who had proven infections (microfilariae (mf) detected in the skin) and were residents of a region highly endemic for onchocerciasis in Mali. Sera from patients with other filarial infections were used to ascertain diagnostic specificity of OV-16. A sensitivity of 90% (37/41) and a specificity of 98% (1/57) for O. volvulus were obtained. The course of the humoral immune response to OV-16 in parallel with the onset of patency (first detection of mf in the skin) was monitored in 2 chimpanzees experimentally inoculated with infective O. volvulus larvae. In these chimpanzees, antibodies to OV-16 developed 3 months and 12 months before the appearance of skin mf. Because infection of children can be an important epidemiological indicator of ongoing transmission of O. volvulus, the antibody response to OV-16 was analyzed in 8 exposed but parasitologically negative children (aged 1 to 14) who were part of a 4-year longitudinal study in Mali. In 3 of the children, O. volvulus infection could be detection by the presence of antibodies to OV-16 during the prepatent period, 1 to 1.5 years before the appearance of mf in the skin. In 4 other children, significant levels of antibody were observed in the same year that mf appeared in the skin. In the 8th child, no clinical, parasitological, or serological evidence of infection was observed and the child was assumed to be truly uninfected.
KW  - Antigens
KW  - Children
KW  - clones
KW  - complementary DNA
KW  - ELISA
KW  - Filariids
KW  - Human diseases
KW  - Immune response
KW  - Immunodiagnosis
KW  - Africa
KW  - Mali
KW  - Man
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - ACP Countries
KW  - Francophone Africa
KW  - Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - antigenicity
KW  - cDNA
KW  - enzyme linked immunosorbent assay
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - Secernentea
KW  - serological diagnosis
KW  - Spirurida
KW  - Host Resistance and Immunity (HH600) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus.
AU  - Kaslow, D. C.
AU  - Isaacs, S. N.
AU  - Quakyi, I. A.
AU  - Gwadz, R. W.
AU  - Moss, B.
AU  - Keister, D. B.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1991///
VL  - 252
IS  - 5010
SP  - 1310
EP  - 1313
SN  - 0036-8075
AD  - Kaslow, D. C.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
N1  - Accession Number: 19910874410.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology
N2  - The surface of mammalian cells infected with a recombinant vaccinia virus that expressed Pfs25 specifically bound transmission-blocking monoclonal antibodies. Furthermore, major histocompatibility complex-disparate congenic mouse strains immunized with recombinant Pfs25 elicited transmission-blocking antibodies, demonstrating that the capacity to develop transmission-blocking antibodies is not genetically restricted in mice. It is suggested that live recombinant viruses may provide an inexpensive, easily administered alternative to subunit vaccines prepared from purified recombinant proteins to block transmission of malaria in developing countries.
KW  - immunization
KW  - Laboratory animals
KW  - Malaria
KW  - parasites
KW  - recombinant vaccines
KW  - Apicomplexa
KW  - mice
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Rodents
KW  - vaccinia virus
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Centrally administered cholecystokinin suppresses feeding through a peripheral-type receptor mechanism.
AU  - Crawley, J. N.
AU  - Fiske, S. M.
AU  - Durieux, C.
AU  - Derrien, M.
AU  - Roques, B. P.
JO  - Journal of Pharmacology and Experimental Therapeutics
JF  - Journal of Pharmacology and Experimental Therapeutics
Y1  - 1991///
VL  - 257
IS  - 3
SP  - 1076
EP  - 1080
SN  - 0022-3565
AD  - Crawley, J. N.: Unit on Behavioural Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bldg. 10, Room 2N214, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931467106.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref. Registry Number: 9011-97-6.  Subject Subsets: Human Nutrition
N2  - Agonists and antagonists selective for brain-type (cholecystokinin (CCK)-B) and peripheral-type (CCK-A) CCK receptor were used to localize site(s) of action at which CCK inhibits food consumption in male Sprague-Dawley rats weighing 250 g. BC 264, a highly selective CCK-B receptor agonist, did not decrease consumption of a palatable meal when given intraperitoneally or into the lateral ventricles of the brain (i.v.t.), whereas CCK decreased feeding when administered i.p. at the same doses. CCK decreased feeding when administered i.v.t. at a high dose, 5 µg. L-364,718, an antagonist selective for the CCK-A receptor, blocked completely the action of centrally administered CCK, whereas L-365,260, a selective CCK-B receptor antagonist, had no effect on the ability of centrally administered CCK to inhibit feeding. To estimate the quantity of i.v.t.-administered CCK which reached the periphery, a tracer of radiolabelled [³H]p-CCK8 ([³H]CCK octapeptide sulfate), combined with unlabelled pCCK8 (5 µg) was administered centrally. Thirty min after administration, intact radiolabelled pCCK8 was extracted from the plasma and estimated in the blood in nanomolar concentrations, exceeding the amounts of CCK octapeptide sulfate reported previously to be present in the plasma after a meal. Intraventricularly administered CCK thus seems to reduce feeding in the rat through a mechanism involving a CCK-A receptor subtype in the periphery.
KW  - Food intake
KW  - Pancreozymin
KW  - Man
KW  - Rats
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - cholecystokinin
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Muscle mitochondrial morphology, body composition, and energy expenditure in sedentary individuals.
AU  - Kirkwood, S. P.
AU  - Zurlo, F.
AU  - Larson, K.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1991///
VL  - 260
IS  - 1 pt 1
SP  - E89
EP  - E94
SN  - 0002-9513
AD  - Kirkwood, S. P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19931454425.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Human Nutrition
N2  - The relationship between metabolic rate and muscle mitochondrial morphology and/or muscle respiration was investigated. 17 healthy volunteers, of both sexes, who did not undertake regular exercise, received a weight-maintaining diet for 3 days before commencement of metabolic studies. There was no relationship between mitochondrial morphology or muscle respiration and 24-h energy expenditure or basal metabolic rate. Central distribution of body fat showed a significant negative correlation with mitochondrial volume density (r = -0.58); central and peripheral mitochondrial volume density (r = -0.59 and -0.48, respectively); and muscle respiration (r = -0.59). It is concluded that central distribution of body fat is associated with (1) lower mitochondrial density and larger mitochondria in skeletal muscle; and (2) decreased oxidative capacity of muscle.
KW  - Body fat
KW  - distribution
KW  - metabolism
KW  - mitochondria
KW  - skeletal muscle
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of endurance training on sedentary energy expenditure measured in a respiratory chamber.
AU  - Schulz, L. O.
AU  - Nyomba, B. L.
AU  - Alger, S.
AU  - Anderson, T. E.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1991///
VL  - 260
IS  - 2 Pt 1
SP  - E257
EP  - E261
SN  - 0002-9513
AD  - Schulz, L. O.: E. Ravussin, National Institutes of Health, 4212 N. 16th St., Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19921445448.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - The effect of endurance training on 24-h energy expenditure (EE), basal metabolic rate (BMR), sleeping metabolic rate (SMR), and the thermic effect of food (TEF) was assessed in a respiratory chamber where only spontaneous physical activity (SPA) was allowed. Results from 20 highly trained male endurance athletes (25±5 years old, 178±7 cm, 70±8 kg body weight, 64±7 kg fat-free mass) were compared with those of 43 untrained men who were matched for age (28±6 years old), height (175±5 cm), weight (73±13 kg), and fat-free mass (62±8 kg). Subjects were admitted to a metabolic ward, fed on a weight-maintenance diet with no physical activity for at least 2 days before measurements. No significant differences were found with respect to 24-h EE (2126±186 vs. 2154±245 kcal), BMR (1808±342 vs. 1709±329 kcal), SMR (1523±120 vs. 1555±188 kcal), or TEF (24.9±9.2 vs. 21.3±6/7% of ingested energy; these values included the energy cost of arousal) between trained and untrained subjects, respectively, before or after adjusting for differences in body composition. Neither the 24-h respiratory quotient nor the level of SPA differed between the 2 groups. No relation was found between maximal aerobic capacity and metabolic rate adjusted for differences in fat-free mass and fat mass. The results do not support an effect of fitness level on EE estimates under sedentary conditions. Therefore, although physical activity plays an important role in maintaining optimal health and body weight, its effect on energy output does not extend beyond the cost of the activity and recovery periods.
KW  - Athletes
KW  - calorimetry
KW  - energy exchange
KW  - physical fitness
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorimetric methods
KW  - keep fit
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445448&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy expenditure by doubly labeled water: validation in lean and obese subjects.
AU  - Ravussin, E.
AU  - Harper, I. T.
AU  - Rising, R.
AU  - Bogardus, C.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1991///
VL  - 261
IS  - 3, I
SP  - E402
EP  - E409
SN  - 0002-9513
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19921451251.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - The doubly labelled water (²H218O) method to assess energy expenditure in free-living conditions has been successfully validated against gas exchange measurements in lean healthy volunteers in both sedentary conditions and during sustained heavy exercise. However, no data are available on obese subjects. Therefore, the ²H218O method was compared with indirect calorimetry (respiratory chamber) in 12 male subjects covering a wide range of body weight and composition (61-190 kg, 7-41% fat). Isotope pool sizes and elimination rates were calculated from 18O and ²H enrichments in baseline urine samples and in 7-h, 11.5-h, and daily post-dose urine samples using the multipoint slope/intercept method. Results were corrected for isotopic fractionation. Mean 7-day energy expenditure in the respiratory chamber varied from 1851 to 4105 kcal per day. The doubly labelled water method tended to underestimate energy expenditure (-2.5±5.8%, range -14 to +4%), with the larger underestimate observed in heavier and fatter subjects. The correlations of error in energy expenditure with body fat percentage and fat mass were -0.82 and -0.68, P&lt;0.02, respectively. The underestimation in heavier subjects might be related to larger sequestration of deuterium during fat synthesis. In conclusion, the doubly labelled water method is a suitable and accurate method to measure energy expenditure in free-living conditions, but might provide a slighty underestimated figure in fatter subjects.
KW  - calorimetry
KW  - energy cost of activities
KW  - estimation
KW  - Obesity
KW  - tracer techniques
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorimetric methods
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - NIH technology assessment conference statement on bovine somatotropin.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1991///
VL  - 265
IS  - 11
SP  - 1423
EP  - 1425
SN  - 0098-7484
AD  - Office of Medical Applications of Research, Bidg 1, Room 260, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920455799.  Publication Type: Journal Article.  Corporate Author: USA, National Institutes of Health Language: English.  Registry Number: 9002-72-6.  Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2  - In Dec. 1990 a Technology Assessment Panel was set up by the National Institutes of Health (Bethesda, Maryland, USA) to consider the scientific evidence relating to the safety of milk and meat for human consumption derived from recombinant bovine somatotropin (rGH)-treated cows, as well as the evidence relating to the effects of rGH on the health of cows. The panel considered the following subjects, which are discussed in this article: (1) methods of monitoring the role of milk in human nutrition and its safety for human consumption; (2) the nature of the comparative biology of human and bovine lactation, and milk composition; (3) the effect of rGH on milk yield of cows, and on the nutritional quality and hormonal content of their meat and milk; (4) the health effects on cows treated with rGH; (5) the health effects on humans who have consumed meat or milk from cows given rGH; (6) and whether further animal and human research is needed in association with the use of rGH.
KW  - animal welfare
KW  - Cows
KW  - milk
KW  - milk composition
KW  - milk yield
KW  - public health
KW  - Somatotropin
KW  - USA
KW  - cattle
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - animal rights
KW  - growth hormone
KW  - milk constituents
KW  - United States of America
KW  - Health Services (UU350) 
KW  - Dairy Animals (LL110) 
KW  - Milk and Dairy Produce (QQ010) 
KW  - Food Composition and Quality (QQ500) 
KW  - Animal Welfare (LL810) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920455799&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation.
AU  - Accili, D.
AU  - Mosthaf, L.
AU  - Ullrich, A.
AU  - Taylor, S. I.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1991///
VL  - 266
IS  - 1
SP  - 434
EP  - 439
SN  - 0021-9258
AD  - Accili, D.: Biochemistry and Molecular Pathophysiology Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921448251.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - A mutation which substitutes valine for phenylalanine382 in the α subunit of the insulin receptor was shown to impair the ability of insulin to activate receptor autophosphorylation in studies with NIH-3-T3 fibroblasts transfected with mutant or wild type human insulin receptor. Furthermore, the Val382 receptor has reduced activity to phosphorylate other peptide substrates in the presence of insulin. Nevertheless, when the Val382 mutant and wild-type receptors are mixed together, the wild-type human insulin receptor is able to phosphorylate the Val382 mutant receptor, thereby activating the tyrosine kinase activity of the mutant receptor. Thus, the conformation change caused by the Val382 mutation compromises the ability of the receptor to transmit a signal across the plasma membrane. Furthermore, the observations suggest that receptor phosphorylation by an intermolecular mechanism (i.e. transphosphorylation) may play a role in mediating the action of insulin upon the target cell.
KW  - Insulin
KW  - mutations
KW  - phosphorylation
KW  - receptors
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448251&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study.
AU  - Lauer, M. S.
AU  - Anderson, K. M.
AU  - Kannel, W. B.
AU  - Levy, D.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1991///
VL  - 266
IS  - 2
SP  - 231
EP  - 236
SN  - 0098-7484
AD  - Lauer, M. S.: Framingham Heart Study of the National Heart, Lung and Blood Institute, 5 Thurber St., Framingham, MA 02215, USA.
N1  - Accession Number: 19931456246.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Human Nutrition
N2  - M-mode echocardiograms, which were adequate for estimation of left ventricular mass, were obtained in 3922 healthy participants (1256 men, 1666 women) in the Framingham Heart Study, Maryland, USA. Height and weight were measured and used to calculate body-mass index as an estimate of obesity. Body-mass index was strongly correlated with left ventricular mass. After adjusting for age and load pressure, body-mass index remained a strong independent predictor of left ventricular mass, left ventricular wall thickness and left ventricular internal dimension (P&lt;0.01 for all). Body-mass index was associated with prevalence of echocardiographic left ventricular hypertrophy, particularly in subjects with a body mass index exceeding 30 kg/m². It is concluded that obesity, even of a mild to moderate degree, is significantly correlated with left ventricular mass and that the increase in left ventricular mass associated with obesity reflects increases in left ventricular wall thickness and left ventricular internal dimension.
KW  - heart
KW  - mass
KW  - Obesity
KW  - ventricles
KW  - Maryland
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931456246&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The interaction of monomeric actin with two binding sites on Acanthamoeba actobindin.
AU  - Budd, M. R.
AU  - Lewis, M. S.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1991///
VL  - 266
IS  - 6
SP  - 3820
EP  - 3826
SN  - 0021-9258
AD  - Budd, M. R.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19910872325.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 9064-37-3.  Subject Subsets: Protozoology
N2  - Actobindin from A. castellanii was previously shown to be an 88-residue polypeptide (MW 9761) with an internal tandem repeat of 33-34 amino acids. Sedimentation equilibrium experiments have confirmed this MW for native actobindin. Pyreneglyoxal-labelled actobindin from A. castellanii had a similar MW by sedimentation equilibrium analysis and bound to actin in a manner qualitatively similar to unmodified actobindin as determined by gel electrophoretic analysis of covalently cross-linked products. The stoichiometry of the actin-actobindin interaction was determined from the change in apparent MW of pyreneglyoxal-labelled actobindin in the presence of actin, as determined by scanning the ultracentrifuge cell at a wavelength that detected only the labelled protein. These data were consistent with the formation of a complex containing 2 actin and one actobindin molecules. The overall KDdescribing the binding of the first actin to either of the 2 sites on actobindin was 3.3 µM. The binding constant for the 2nd actin suggested either negative cooperativity or inequality of the 2 actin binding sites. Similar binding constants were obtained by analysis of the fluorescence enhancement that occurred when actobindin bound to actin labelled with either pyrene iodoacetamide or 4-(N-iodoacetoxyethyl-N-methyl)-7-nitrobenz-2-oxa-1,3-diazole. Cross-linking experiments with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide and N-hydroxysulfosuccinimide qualitatively agreed with predictions made from a 2-binding site model. Additionally, both the fluorescence and cross-linking experiments suggested that the interaction of the 2 actin molecules may contribute to the stability of the heterotrimeric complex.
KW  - actin
KW  - Biochemistry
KW  - parasites
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - actobindin
KW  - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872325&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The discovery of creatinine assimilation in Cryptococcus neoformans, and subsequent work on the characterization of the two varieties of C. neoformans.
AU  - Kwon-Chung, K. J.
JO  - Zentralblatt für Bakteriologie
JF  - Zentralblatt für Bakteriologie
Y1  - 1991///
VL  - 275
IS  - 3
SP  - 390
EP  - 393
SN  - 0934-8840
AD  - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911210471.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The discovery of creatinine assimilation in C. neoformans served as the foundation for biochemical, genetic, ecological, epidemiological and taxonomic studies on the 2 varieties of C. neoformans during a 15-yr period. The results of these investigations are summarized. It is concluded that the 2 varietal concept is now widely accepted and the arrival of the AIDS epidemic has promoted the recognition of the differences between the 2 varieties, especially in their epidemiology and ecology. Since the agent of cryptococcosis in AIDS patients almost always belongs to the var. neoformans even in geographical areas prevalent for var. gattii, it is suggested that it is now important to study the possible differences in the pathogenesis of the 2 varieties.
KW  - taxonomy
KW  - Cryptococcus gattii
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus neoformans
KW  - Cryptococcus neoformans var. gattii
KW  - fungus
KW  - systematics
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210471&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomised trials.
AU  - Teo, K. K.
AU  - Yusuf, S.
AU  - Collins, R.
AU  - Held, P. H.
AU  - Peto, R.
JO  - British Medical Journal (Clinical Research edition)
JF  - British Medical Journal (Clinical Research edition)
Y1  - 1991///
VL  - 303
IS  - 6816
SP  - 1499
EP  - 1503
SN  - 0959-8138
AD  - Teo, K. K.: S. Yusuf, Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19921444683.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 7439-95-4.  Subject Subsets: Human Nutrition
N2  - To investigate the effect of intravenous magnesium on mortality in suspected acute myocardial infarction, a systematic overview of 7 randomised trials in which 1301 patients were allocated to receive either intravenous Mg or otherwise similar treatment without Mg in coronary care units of several hospitals was undertaken. Considering the 7 trials collectively there were 25 (3.8%) deaths among 657 patients allocated to receive Mg and 53 (8.3%) deaths among 644 patients allocated control, generally during hospital follow-up. This represents a 55% reduction in the odds of death (P&lt;0.001) with 95% confidence intervals ranging from about one-third to about two-thirds. 70 of 648 patients allocated Mg compared with 109 of 641 controls had serious ventricular arrhythmias, suggesting that Mg reduces the incidence, though the definition varied among trials. Other adverse effects were rare in the limited number of patients for whom data were available. It is concluded that despite the limited number of patients randomised, this overview suggests that intravenous Mg therapy may reduce mortality in patients with acute myocardial infarction. Further large scale trials to confirm (or refute) these findings are desirable.
KW  - magnesium
KW  - mortality
KW  - Myocardial infarction
KW  - parenteral feeding
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - death rate
KW  - heart attack
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921444683&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Oxoaporphine alkaloids: conversion of lysicamine into liriodendronine and its 2-O-methyl ether, and antifungal activity.
AU  - Pabuccuoglu, V.
AU  - Rozwadowska, M. D.
AU  - Brossi, A.
AU  - Clark, A.
AU  - Hufford, C. D.
AU  - George, C.
AU  - Flippen-Anderson, J. L.
JO  - Archiv der Pharmazie (Weinheim)
JF  - Archiv der Pharmazie (Weinheim)
Y1  - 1991///
VL  - 324
IS  - 1
SP  - 29
EP  - 33
SN  - 0365-6233
AD  - Pabuccuoglu, V.: Medicinal Chemistry Section, LAC, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911209661.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Oxoaporphine alkaloids including lysicamine, liriodendronine and its 2-O-methyl ether were synthesized and tested for antifungal activity against Candida albicans.
KW  - antifungal agents
KW  - antifungal properties
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Oxoaporphine alkaloids
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Analysis of aqueous humor in ocular toxoplasmosis.
AU  - Brézin, A. P.
AU  - Eqwuagu, C. E.
AU  - Silveira, C.
AU  - Thulliez, P.
AU  - Martins, M. C.
AU  - Mahdi, R. M.
AU  - Belfort, R., Jr.
AU  - Nussenblatt, R. B.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1991///
VL  - 324
IS  - 10
SP  - 699
EP  - 699
SN  - 0028-4793
AD  - Brézin, A. P.: National Eye Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920884448.  Publication Type: Correspondence.  Language: English.  Number of References: 6 ref. Subject Subsets: Protozoology
N2  - The correspondents report the use of the polymerase chain reaction to identify Toxoplasma gondii in aqueous humor in patients with presumed ocular toxoplasmosis. This method is of particular use when diagnosis is needed in cases of atypical retinitis or when the fundus is masked by vitreal inflammation. Samples of aqueous humor from 17 Brazilian patients with clinical presentations consistent with ocular toxoplasmosis were examined. All patients were seropositive for toxoplasmosis. Using the polymerase chain reaction T. gondii DNA was detected in the aqueous humor of 3 patients during 2 independent amplifications of the B1 gene fragment. The amplified product was detected by Southern blot analysis with an oligonucleotide internal to the amplified fragment. This is believed to be the first method reported that can identify the parasite in human aqueous humor.
KW  - diagnosis
KW  - eyes
KW  - human diseases
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - Brazil
KW  - North America
KW  - South America
KW  - USA
KW  - apicomplexa
KW  - man
KW  - protozoa
KW  - sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - aqueous humor
KW  - biochemical genetics
KW  - PCR
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of circulating Candida enolase by immunoassay in patients with cancer and invasive candidiasis.
AU  - Walsh, T. J.
AU  - Hathorn, J. W.
AU  - Sobel, J. D.
AU  - Merz, W. G.
AU  - Sanchez, V.
AU  - Maret, S. M.
AU  - Buckley, H. R.
AU  - Pfaller, M. A.
AU  - Schaufele, R.
AU  - Sliva, C.
AU  - Navarro, E.
AU  - Lecciones, J.
AU  - Chandrasekar, P.
AU  - Lee, J.
AU  - Pizzo, P. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1991///
VL  - 324
IS  - 15
SP  - 1026
EP  - 1031
SN  - 0028-4793
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19911209112.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A total of 170 patients at high risk for invasive candidosis were tested for Candida enolase antigenaemia. All the patients had cancer and neutropenia. Antigen was detected using a double-sandwich liposomal immunoassay for Candida enolase in serially collected serum samples. Invasive candidosis was proved by finding Candida spp. in deep nonmucosal tissue, blood cultures or both. Among 24 patients with proved invasive candidosis (caused by C. albicans, C. tropicalis, C. parapsilosis and Candida sp.), 149 serum samples were tested for enolase antigenaemia; 80 were positive and 69 negative (sensitivity per sample, 54%). Multiple sampling improved the detection of antigenaemia, which was found in 11 of 13 proved cases of deep tissue infection (85%) and in 7 of 11 proved cases of fungaemia (64%). Specificity was 96% as measured against control groups including patients with mucosal colonization, bacteraemia and other deep mycoses. Antigenaemia was detected in the absence of fungaemia in 5 cases of deep tissue candidosis, but was not detected in 6 cases of fungaemia alone. It is concluded that Candida enolase antigenaemia is a novel marker for invasive candidosis and that it may be a useful indicator of deep infection in patients with cancer and neutropenia and may complement the diagnostic usefulness of blood cultures.
KW  - antigens
KW  - hosts
KW  - immunoassay
KW  - immunological techniques
KW  - immunology
KW  - infections
KW  - neoplasms
KW  - predisposition
KW  - USA
KW  - Candida
KW  - Candida albicans
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - cancers
KW  - fungus
KW  - Hyphomycetes
KW  - immunogens
KW  - serological techniques
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome.
AU  - Falloon, J.
AU  - Kovacs, J.
AU  - Hughes, W.
AU  - O'Neill, D.
AU  - Polis, M.
AU  - Davey, R. T., Jr.
AU  - Rogers, M.
AU  - Lafon, S.
AU  - Feuerstein, I.
AU  - Lancaster, D.
AU  - Land, M.
AU  - Tuazon, C.
AU  - Dohn, M.
AU  - Greenberg, S.
AU  - Lane, H. C.
AU  - Masur, H.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1991///
VL  - 325
IS  - 22
SP  - 1534
EP  - 1538
SN  - 0028-4793
AD  - Falloon, J.: Bldg. 10, Rm. 7D43, Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920876624.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Protozoology; Public Health
N2  - An open-label trial of 566C80 (a hydroxynaphthoquinone) in 34 adults from the USA with AIDS and untreated P. carinii pneumonia (PCP). All the patients had a partial pressure of arterial oxygen of at least 60 mm Hg while breathing room air. They were enrolled sequentially in 3 cohorts taking 566C80 at different dosages, all administered orally: 750 mg 3 times daily for 5 days, then twice daily for 16 days; 750 mg 3 times daily for 21 days; and 750 mg 4 times daily for 21 days. All 34 patients survived, and 27 (79%) were successfully treated with 566C80 alone. The mean partial pressure of oxygen in 33 patients was 78 mm Hg at entry and 93 mm Hg after the course of 566C80. In 5 patients (15%) the drug was discontinued because of lack of response. In 4 patients (12%), the drug was discontinued because of toxicity (fever and rash in 2 patients each). In 2 of these, treatment was considered to have succeeded because 566C80 was not discontinued because of toxicity until after day 14. Five of the successfully treated patients had rashes that resolved despite continued therapy. In 9 patients, serum alanine aminotransferase levels rose above 100 U/litre. During the first 3 months after the completion of therapy, PCP recurred in 4 of the 27 successfully treated patients, and another 3 patients had recurrences between month 3 and month 6 of follow-up. The mean (±SEM) steady-state plasma levels of 566C80 were similar in the 3 cohorts: 16.3±2.10, 20.4±2.48, and 18.9±3.08 µg/ml in the patients taking the drug twice daily, 3 times daily, and 4 times daily, respectively. From these preliminary data, the investigational compound 566C80 is concluded to be a safe, effective, and well-tolerated therapy for PCP of mild-to-moderate severity in patients with AIDS.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The hydroxynaphthoquinone 566C80 is active against Pneumocystis carinii in vitro and in animal models. Initial studies in humans indicate that it is safe and has adequate bioavailability after oral administration. In an open-label trial of 566C80 34 adults with AIDS and untreated Pneumocystis pneumonia were enrolled sequentially in 3 cohorts taking 566C80 at different dosages, all administered orally: 750 mg 3 times daily for 5 days, then twice daily for 16 days; 750 mg 3 times daily for 21 days; and 750 mg 4 times daily for 21 days. All 34 patients survived, and 27 (79%) were successfully treated with 566C80 alone. In 5 patients (15%) the drug was discontinued because of lack of response. In 4 patients (12%) the drug was discontinued because of toxicity (fever and rash in 2 patients each). In 2 of these, treatment was considered to have succeeded because 566C80 was not discontinued because of toxicity until after day 14. Five of the successfully treated patients had rashes that resolved despite continued therapy. In 9 patients, serum alanine aminotransferase activities rose above 100 U/l. During the first 3 months after the completion of therapy, Pneumocystis pneumonia recurred in 4 of the 27 successfully treated patients, and another 3 patients had recurrences between month 3 and month 6 of follow-up. The mean (± SEM) steady-state plasma levels of 566C80 were similar in the 3 cohorts: 16.3 ± 2.10, 20.4 ± 2.48, and 18.9 ± 3.08 µg per milliliter in the patients taking the drug twice daily, 3 times daily, and 4 times daily, respectively.D.W. FitzSimons
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - adverse effects
KW  - Antiprotozoal agents
KW  - clinical aspects
KW  - clinical trials
KW  - drug therapy
KW  - Efficacy
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Novel antiprotozoal agents
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - pneumocystosis
KW  - pneumonia
KW  - Treatment
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - 566C80
KW  - adverse reactions
KW  - AIDS
KW  - chemotherapy
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - Hydroxynaphthoquinones
KW  - Hydroxynapthoquinone
KW  - Opportunstic infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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ER  - 

TY  - JOUR
T1  - Oral immunisation against typhoid fever in Indonesia with Ty21a vaccine.
AU  - Simanjuntak, C. H.
AU  - Paleologo, F. P.
AU  - Punjabi, N. H.
AU  - Darmowigoto, R.
AU  - Soeprawoto
AU  - Totosudirjo, H.
AU  - Haryanto, P.
AU  - Suprijanto, E.
AU  - Witham, N. D.
AU  - Hoffman, S. L.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1991///
VL  - 338
IS  - 8774
SP  - 1055
EP  - 1059
SN  - 0140-6736
AD  - Simanjuntak, C. H.: Center for Infectious Diseases Research, National Institutes of Health Research and Development, Ministry of Health, Jalan Percetakan Negara 29, Jakarta 10560, Indonesia.
N1  - Accession Number: 19972007292.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
N2  - When tested under conditions of moderate transmission of typhoid fever, a liquid formulation of the oral typhoid fever vaccine Ty21a had a protective efficacy of 96% in Egypt, and an enteric coated capsule formulation had an efficacy of 67% in Chile. The two formulations were compared under conditions of intense transmission of typhoid fever in Indonesia in a randomized, double-blind trial in 1986. 20 543 subjects (age range 3-44 years) received either 3 doses of enteric coated capsules containing placebo or live Ty21a, or 3 doses of lyophilised placebo or live Ty21a reconstituted with phosphate buffer. During 30 months of follow up (October 1986 to March 1989),the rate of blood-culture-positive typhoid fever among controls was 810/100 000 per year.Rates of typhoid fever were 379/100 000 per year for subjects who received the liquid formulation of vaccine and 468/100 000 per year for subjects who received enteric coated capsules. The protective efficacies of the liquid and enteric coated formulations were 53% and 42% respectively. Neither formulation protected against infections with Salmonella paratyphi A. No major side-effects were noted, but the overall incidence of side-effects was greater in the vaccine groups. Under conditions of intense transmission, Ty21a protected against typhoid fever; however, because Ty21a will not protect all individuals, there is a need for additional approaches to prevent the disease.
KW  - disease transmission
KW  - efficacy
KW  - formulations
KW  - human diseases
KW  - immunization
KW  - typhoid
KW  - vaccines
KW  - Asia
KW  - Indonesia
KW  - man
KW  - salmonella typhi
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - bacterium
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Exposure to certain pesticides may pose real carcinogenic risk.
AU  - Huff, J. E.
AU  - Haseman, J. K.
JO  - Pesticides News
JF  - Pesticides News
Y1  - 1991///
IS  - 12
SP  - 7
EP  - 10
AD  - Huff, J. E.: Division of Biometry and Risk Assessment, US National Institute of Environmental Health Sciences, USA.
N1  - Accession Number: 19940800101.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Medical & Veterinary Entomology
N2  - Based on experience in designing, conducting and evaluating approximately 200 rodent carcinogenicity studies on a variety of chemicals, including pesticides, the authors suggest that there is considerable evidence that exposure to certain pesticides may present real carcinogenic hazard to humans. In the absence of epidemiological data, current rodent bioassays provide guidance to regulators about the need to regulate human exposure to certain pesticides.
KW  - animal experiments
KW  - carcinogenesis
KW  - exposure
KW  - neoplasms
KW  - pesticides
KW  - regulations
KW  - toxicity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - animal research
KW  - cancers
KW  - pesticide legislation
KW  - rules
KW  - Laws and Regulations (DD500) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Endogenous nitrosamines and liver fluke as risk factors for cholangiocarcinoma in Thailand.
AU  - Srivatanakul, P.
AU  - Ohshima, H.
AU  - Khlat, M.
AU  - Parkin, M.
AU  - Sukarayodhin, S.
AU  - Brouet, I.
AU  - Bartsch, H.
A2  - O'Neill, I. K.
A2  - Chen, J.
A2  - Bartsch, H.
T2  - IARC Publication No. 105: Relevance to human cancer of n-nitroso compounds, tobacco and mycotoxins.
JO  - IARC Publication No. 105: Relevance to human cancer of n-nitroso compounds, tobacco and mycotoxins.
JF  - IARC Publication No. 105: Relevance to human cancer of n-nitroso compounds, tobacco and mycotoxins.
Y1  - 1991///
SP  - 88
EP  - 95
CY  - Lyon: International Agency for Research on Cancer
SN  - 9283221052
AD  - Srivatanakul, P.: National Cancer Institute of Thailand, Bangkok, Thailand.
N1  - Accession Number: 19940803763.  Publication Type: Miscellaneous.  Corporate Author: International Agency for Research on Cancer Language: English.  Number of References: 15 ref. Subject Subsets: Helminthology
N2  - An association between cholangiocarcinoma (CCA) and the liver fluke Opisthorchis viverrini (OV) in north-east Thailand has been reported. 12-hour overnight urine samples (after dosing with 500 mg proline and 200 mg ascorbic acid or 500 mg proline alone) from about 100 inhabitants of 5 contrasting incidence areas for CCA and hepatocellular carcinoma were analyzed. It was shown that the incidences of CCA and hepatocellular carcinoma did not correlate with the amount of nitrosamino acids, endogenous nitrosation potential or nitrate level in urine. However, subjects who were positive for OV antibody excreted significantly more N-nitrosamine (NPRO) after proline ingestion than those who were negative. After ingestion of ascorbic acid, the NPRO levels in the positive subjects were significantly reduced, suggesting that endogenous nitrosation of proline was inhibited. These results indicate that the interaction between chemical carcinogens, especially nitrosamines, and OV infestation may play a role in the pathogenesis of CCA in Thailand.
KW  - bile ducts
KW  - carcinoma
KW  - helminths
KW  - human diseases
KW  - liver diseases
KW  - neoplasms
KW  - opisthorchiasis
KW  - parasites
KW  - pathology
KW  - Asia
KW  - Thailand
KW  - Digenea
KW  - man
KW  - Opisthorchiidae
KW  - Opisthorchis viverrini
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Digenea
KW  - Opisthorchis
KW  - Opisthorchiidae
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - cancers
KW  - opisthorchiosis
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Fatty acid composition of present day diets.
AU  - Ernst, N. D.
A2  - Nelson, G. J.
T2  - Health effects of dietary fatty acids.
JO  - Health effects of dietary fatty acids.
JF  - Health effects of dietary fatty acids.
Y1  - 1991///
SP  - 1
EP  - 11
CY  - Champaign; USA
PB  - American Oil Chemists Society
SN  - 0935315314
AD  - Ernst, N. D.: National Heart, Lung and Blood Institute, National Institutes of Health, 7550 Wisconsin Avenue, Room 204, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931459200.  Publication Type: Conference paper.  Language: English.  Number of References: 21 ref. Subject Subsets: Human Nutrition
N2  - Trends in fat consumption in the USA including the contribution of foods and food groups to fat intake and the fatty acid composition of US diets are reviewed.
KW  - composition
KW  - Diet
KW  - Diet studies
KW  - Fat consumption
KW  - fatty acids
KW  - reviews
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Health effects of dietary fatty acids
KW  - United States of America
KW  - Food Composition and Quality (QQ500) 
KW  - Other Produce (QQ070) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Role of dengue virus membrane protein in resistance.
AU  - Bray, M.
AU  - Lai ChingJuh
A2  - Chanock, R.M.
A2  - Ginsberg, H.S.
A2  - Brown, F.
A2  - Lerner, R.A.
T2  - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS.
JO  - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS.
JF  - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS.
Y1  - 1991///
SP  - 245
EP  - 249
CY  - Plainview, NY; USA
PB  - Cold Spring Harbor Laboratory
SN  - 0879693673
AD  - Bray, M.: Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950507452.  Publication Type: Miscellaneous.  Language: English.  Number of References: 4 ref.
N2  - Vaccinia recombinants containing cDNA encoding dengue virus pre-M, M and non-M proteins expressed apparently authentic proteins. Mice immunized with recombinants expressing D4 pre-M or the M protein, which forms part of the dengue virion, were protected against subsequent dengue virus challenge. A recombinant expressing non-M, the portion of pre-M discarded during virion maturation, gave no protection. The dengue M protein constitutes a protective antigen of dengue virus that should be taken into consideration in the development of dengue virus vaccines.
KW  - arboviruses
KW  - immunization
KW  - laboratory animals
KW  - membranes
KW  - recombinant DNA
KW  - vaccines
KW  - viral proteins
KW  - dengue virus
KW  - mice
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Carboxy-terminally truncated dengue virus envelope glycoprotein expressed on the cell surface exhibit increased immunogenicity in mice.
AU  - Men RuHe
AU  - Bray, M.
AU  - Lai ChingJuh
A2  - Chanock, R.M.
A2  - Ginsberg, H.S.
A2  - Brown, F.
A2  - Lerner, R.A.
T2  - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS.
JO  - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS.
JF  - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS.
Y1  - 1991///
SP  - 251
EP  - 257
CY  - Plainview, NY; USA
PB  - Cold Spring Harbor Laboratory
SN  - 0879693673
AD  - Men RuHe: Molecular Virology Biology Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950507453.  Publication Type: Miscellaneous.  Language: English.  Number of References: 5 ref.
N2  - The antigenic structure of dengue envelope (E) glycoprotein was investigated with the goal of increasing its immunogenicity. Recombinant vaccinia viruses were constructed that contained dengue cDNA coding for carboxy-terminally truncated E that ranged in length from 9% to 99% of the amino-terminal sequence. Overall antigenicity of the E products was analysed by radioimmunoprecipitation using dengue HMAF or an E peptide antiserum. Truncated E that was 79% or less in length did not bind HMAF efficiently, whereas E constructs &gt;79% were able to bind HMAF with high efficiency. An R residue at position 392 in the dengue-type-4 E sequence immediately following the 79% E carboxyl terminus appeared to be critical for proper conformation and antigenic structure required for efficient binding by HMAF. Truncated E ranging from 59% to approximately 80% in length was secreted extracellularly, whereas larger E constructs were retained intracellularly. Only constructs that contained 79% E plus 1 to 5 amino acids of the downstream RKGSS sequence were expressed in high concentration on the surface of recombinant-virus-infected cells, presumably being inserted into the plasma membrane by a carboxy-terminal membrane anchor. Studies in mice indicated that only truncated E constructs that were recognized efficiently by HMAF induced a high level of resistance to dengue virus encephalitis. Among the truncated E constructs that were able to bind HMAF efficiently, only 79% E-RKG was expressed in high concentration on the cell surface. Significantly, only 79% E-RKG induced an appreciable E antibody response, suggesting that cell-surface expression was responsible for its enhanced immunogenicity. Results from plaque-reduction and neutralization tests and passive immunized studies in mice involving serum transfer indicated that serum antibodies to E played a major role in the complete or nearly complete resistance induced by immunization. Finally, dengue-type-2 virus E similarly truncated to 79% E-RKG also exhibited increased protective immunity against homotypic dengue challenge in mice, suggesting that it may be possible to extend this strategy to construct E glycoproteins of other flaviviruses that are more immunogenic and protective.
KW  - arboviruses
KW  - glycoproteins
KW  - immunization
KW  - laboratory animals
KW  - vaccines
KW  - viral proteins
KW  - dengue virus
KW  - mice
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Food allergy: adverse reactions to foods and food additives.
A2  - Metcalfe, D. D.
A2  - Sampson, H. A.
A2  - Simon, R. A.
T2  - Food allergy: adverse reactions to foods and food additives.
Y1  - 1991///
CY  - Oxford; UK
PB  - Blackwell Scientific Publications Ltd
SN  - 0865420947
AD  - Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19941404458.  Publication Type: Book.  Language: English.  Number of References: many ref. Subject Subsets: Human Nutrition
N2  - This 29-chapter multiauthor book is divided into a review of food allergy, adverse reactions to food additives and contemporary topics. Aimed at clinicians, nutritionists and scientists interested in food reactions, it covers paediatric and adult reactions to foods. Each chapter reviews current knowledge on a specific topic and overall the text presents a state-of-the-art of research in food allergies.
KW  - antigens
KW  - food additives
KW  - food allergies
KW  - foods
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - food hypersensitivity
KW  - immunogens
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Pneumocystis carinii pneumonia (PCP).
AU  - Lipschik, G. Y.
AU  - Masur, H.
A2  - Sun, T.
T2  - Progress in clinical parasitology; volume 2.
Y1  - 1991///
CY  - Philadelphia, PA; USA
PB  - Field & Wood Inc., Medical Publications
SN  - 0938607367
AD  - Lipschik, G. Y.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19910874431.  Publication Type: Book chapter.  Language: English.  Number of References: 294 ref. Subject Subsets: Protozoology
N2  - A review of P. carinii pneumonia, and its implications in man, with particular reference to AIDS patients, is given. The clinical manifestations, histopathology, diagnosis, therapy, prognostic factors, residual effects, and prophylaxis are examined in detail.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Lungs
KW  - Opportunistic infections
KW  - parasites
KW  - Pneumonia
KW  - reviews
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - progress in clinical parasitology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet.
AU  - Zheng, W.
AU  - Blot, W. J.
AU  - Shu, X. O.
AU  - Diamond, E. L.
AU  - Gao, Y. T.
AU  - Ji, B. T.
AU  - Fraumeni, J. F., Jr.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1992///
VL  - 1
IS  - 6
SP  - 441
EP  - 441
SN  - 1055-9965
AD  - Zheng, W.: National Cancer Institute, Executive Plaza North, Room 431, Bethesda, MD 20392, USA.
N1  - Accession Number: 19941401594.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition
N2  - A population-based case-control study of oral and pharyngeal cancer was conducted in Shanghai, China, from 1988 to 1990, in which 204 (115 male, 89 female) incident cases and 414 (269 male, 145 female) controls were interviewed. Cigarette smoking and alcohol consumption, as well as occupational exposure to asbestos and to petroleum products and the use of kerosene stoves in cooking, were associated with increased risk of oral and pharyngeal cancer. In addition, more cases than controls reported having chronic oral diseases and false teeth. Dietary intakes of 42 major foods and selected salt-preserved or deep-fried foods during the past 10 years, ignoring any recent changes, were measured by a structured quantitative food questionnaire. The findings confirmed that dietary factors play an important role in the development of oral and pharyngeal cancer. High consumption of salt-preserved meat and fish was associated with an excess risk in this respect.
KW  - alcoholic beverages
KW  - carcinoma
KW  - diet
KW  - larynx
KW  - mouth
KW  - risk
KW  - tobacco smoking
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - People's Republic of China
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401594&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Height and weight at various ages and risk of breast cancer.
AU  - Brinton, L. A.
AU  - Swanson, C. A.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1992///
VL  - 2
IS  - 5
SP  - 597
EP  - 597
SN  - 1047-2797
AD  - Brinton, L. A.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951404263.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - Risk in relation to lifetime changes in body size was studied in 1529 patients with mammary neoplasms and 1901 controls. Tallness, regardless of when achieved, was associated with increased risk of breast cancer diagnosed at young (before 50 years old) and older ages, with adult height of 68 in or more increasing risk by nearly 50 to 80% compared with heights less than 62 in. Association of risk with weight was less clear. Women who described themselves as heavier than average at 8 to 9 or 16 years old were at reduced risk, particularly for older-onset breast cancer. Greater body mass indices based on reported weight during early adulthood were also associated with reduced risk. Measures of body mass beyond 20 years old were less strongly related to risk. These inconsistent patterns seemed to be explained by an effect on risk of weight gain later in life, which was related to reduced risks for young-onset cancer and increased risks for later disease. Effect of weight change for early-onset cancer was not restricted to neoplasms in situ and could therefore not be attributed to detection bias. The direct relation of body mass change with older-onset disease was restricted to invasive neoplasms, consistent with observations of poor breast cancer prognosis among obese women.
KW  - age
KW  - height
KW  - mammary gland neoplasms
KW  - risk
KW  - weight
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mammary tumour
KW  - Human Nutrition (General) (VV100) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404263&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lipids and risk of coronary heart disease: The Framingham Study.
AU  - Castelli, W. P.
AU  - Anderson, K.
AU  - Wilson, P. W. F.
AU  - Levy, D.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1992///
VL  - 2
IS  - 1/2
SP  - 23
EP  - 28
SN  - 1047-2797
AD  - Castelli, W. P.: Framington Heart Study, National Heart Lung and Blood Institute, 5 Thurber Street, Framingham, MA 01701, USA.
N1  - Accession Number: 19941400573.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Human Nutrition
N2  - Data from the Framingham Study (Massachusetts, USA) was used to study the risk attributable to total cholesterol value in old age. The population used included 922 men and 1295 women 50 to 79 years old who were free of cardiovascular disease when lipoprotein fractions were estimated between 1968 and 1973. Total cholesterol value was significantly related to risk of heart disease, adjusted for other risk factors in women 50 to 79 years old and in men 50 to 44 years old (P&lt;0.001). Prediction of risk was improved by the estimation of low-density lipoprotein cholesterol and high-density lipoprotein (HDL) cholesterol. Triacylglycerols were independently related in women at all ages but were not significant in multivariate studies in men. Total cholesterol:HDL cholesterol ratio was a strong predictor at all ages in women and was the only lipid predictor independently related to heart disease in men 65 to 80 years old. Absolute rates of disease increased with age.
KW  - blood lipids
KW  - heart diseases
KW  - risk
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - coronary diseases
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cholesterol as a risk factor for coronary heart disease in elderly men. The Baltimore Longitudinal Study of Aging.
AU  - Sorkin, J. D.
AU  - Andres, R.
AU  - Muller, D. C.
AU  - Baldwin, H. L.
AU  - Fleg, J. L.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1992///
VL  - 2
IS  - 1/2
SP  - 59
EP  - 67
SN  - 1047-2797
AD  - Sorkin, J. D.: Gerontology Research Center, National Institute on Aging, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19941400578.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The relation of cholesterol to heart disease (angina pectoris, myocardial infarction and sudden coronary death) was studied in 1052 men who were participants in the Baltimore (Maryland, USA) Longitudinal Study on Aging (a study of healthy, highly educated, middle class adults begun in 1958). The men were grouped according to age: 29 to 64 years (801), 65 to 74 years (357) and 75 to 97 years (250). In all 3 groups, cholesterol was a significant risk factor for heart disease. In the oldest group the relation between cholesterol and risk was linear (P=0.003); in the younger groups it was exponential.
KW  - blood
KW  - cholesterol
KW  - heart diseases
KW  - old age
KW  - risk
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - coronary diseases
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400578&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cholesterol, coronary heart disease, and total mortality in middle-aged and elderly men and women in Tecumseh.
AU  - Higgins, M.
AU  - Keller, J. B.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1992///
VL  - 2
IS  - 1/2
SP  - 69
EP  - 76
SN  - 1047-2797
AD  - Higgins, M.: National Heart, Lung and Blood Institute, Federal Building, Room 2C08, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941400579.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Relations between serum cholesterol and heart disease were studied in men and women 45 to 92 years old initially free from heart disease living in Tecumseh, Michigan, USA. Recruitment continued through 3 cycles of examinations during 10 years, beginning in 1959. Follow-up for mortality ended in 1986-87. Age-adjusted relative risks for death from heart disease for cholesterol values of 5.2 to 6.2 and greater than 6.2 mmol/litre, compared with values less than 5.2 mmol/litre for men 45 to 64 years old, were 1.2 and 1.7; for older men they were 1.0 and 1.8. Comparable relative risks for death from heart disease by cholesterol value were 0.7 and 1.4 for women 45 to 64 years old and 0.8 and 0.7 for older women. Coefficients for cholesterol were significant for fatal heart disease in men under and in those 65 years and older when age, systolic blood pressure, body mass index, cigarette smoking status and glucose intolerance were controlled in proportional hazards models. Cholesterol was a significant predictor of fatal heart disease plus non-fatal infarction in middle-aged but not elderly women. Relative risks for total mortality were lowest for middle-aged men and women with cholesterol 5.2 to 6.2 mmol/litre.
KW  - age
KW  - blood
KW  - cholesterol
KW  - heart diseases
KW  - mortality
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - coronary diseases
KW  - death rate
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400579&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cholesterol and heart disease in older persons and women. Review of an NHLBI workshop.
AU  - Manolio, T. A.
AU  - Pearson, T. A.
AU  - Wenger, N. K.
AU  - Barrett-Connor, E.
AU  - Payne, G. H.
AU  - Harlan, W. R.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1992///
VL  - 2
IS  - 1/2
SP  - 161
EP  - 176
SN  - 1047-2797
AD  - Manolio, T. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Federal Building, Room 212-A, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941400592.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Papers on the value of serum total cholesterol estimation in the prediction of coronary heart disease in older persons and women at a recent US National Heart, Lung and Blood Institute workshop are reviewed.
KW  - blood
KW  - cholesterol
KW  - heart diseases
KW  - prediction
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - coronary diseases
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400592&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The World Health Organization research programme on aging.
AU  - Litvak, J.
JO  - Age & Nutrition
JF  - Age & Nutrition
Y1  - 1992///
VL  - 3
IS  - 1
SP  - 84
EP  - 86
SN  - 1158-0259
AD  - Litvak, J.: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951404286.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Language of Summary: French.  Number of References: 3 ref. Subject Subsets: Human Nutrition
N2  - The WHO research programme on aging was set up in 1987 on the recommendation of the Advisory Committee on Health Research. The 4 initial priority areas are: research on factors responsible for healthy aging; dementias associated with aging; aging of the immune system; changes associated with nutrition, particularly osteoporosis. One of the characteristics of the research is the international approach, with comparison of results from different countries. Such comparative studies have great potential in research on risk factors in disease and disability as well as identification of protective factors leading to healthy aging.
KW  - nutrition research
KW  - old age
KW  - WHO
KW  - Italy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - International meeting on nutrition in old age
KW  - World Health Organization
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404286&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A cohort study of tobacco use, diet, occupation, and lung cancer mortality.
AU  - Chow, W. H.
AU  - Schuman, L. M.
AU  - McLaughlin, J. K.
AU  - Bjelke, E.
AU  - Gridley, G.
AU  - Wacholder, S.
AU  - Chien, H. T. C.
AU  - Blot, W. J.
JO  - Cancer Causes and Control
JF  - Cancer Causes and Control
Y1  - 1992///
VL  - 3
IS  - 3
SP  - 247
EP  - 254
AD  - Chow, W. H.: National Cancer Institute, 6130 Executive Blvd, EPN Room 407, Rockville, MD 20892, USA.
N1  - Accession Number: 19931455874.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 50-81-7, 68-26-8.  Subject Subsets: Human Nutrition
N2  - In 1966, a cohort of 17 818 white males aged 35 or over, who were policy-holders with the Lutheran Brotherhood Insurance Society, USA, completed a questionnaire on tobacco use, diet and demographic characteristics. During the 20 years of follow-up, 219 lung cancer deaths occurred. Besides the strong relation with cigarette smoking, an effect on lung cancer risk was observed among current users of cigars or pipes who were non-smokers of cigarettes (relative risk (RR) = 3.5, 95% confidence interval (CI) = 1.0 to 12.6) or who were past/occasional users of cigarettes (RR = 2.7, CI = 1.4 to 5.3). In addition, elevated risks (from 1.5 to 2.6) of lung cancer were found among craftsmen and labourers, with the highest risks among subjects who worked in the mining or manufacturing industry. No association between current (as to 1966) use of beer or hard liquor and lung cancer was observed, although past users were at elevated risk. An inverse association between lung cancer and intake of fruits was observed, and risks of lung cancer were lower among persons in the highest dietary intake quintiles of vitamins A and C. Except for oranges, however, none of the inverse associations with fruits or dietary nutrients had significant trends. The findings from this cohort study add to the evidence of an adverse effect of cigar/pipe smoking and possible protective effect of dietary factors on lung cancer risk.
KW  - Ascorbic acid
KW  - carcinoma
KW  - diet
KW  - lungs
KW  - Men
KW  - occupations
KW  - Retinol
KW  - risk
KW  - tobacco smoking
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931455874&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mortality among laboratory workers employed at the U.S. Department of Agriculture.
AU  - Dosemeci, M.
AU  - Alavanja, M.
AU  - Vetter, R.
AU  - Eaton, B.
AU  - Blair, A.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1992///
VL  - 3
IS  - 3
SP  - 258
EP  - 262
SN  - 1044-3983
AD  - Dosemeci, M.: Occupational Studies Section, Epidemiology and Biostatistics Program, National Cancer Institute, Building EPN, Room 418, Rockville, MD 20892, USA.
N1  - Accession Number: 19932020078.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - [The authors] evaluated the mortality of 835 white male and 36 female laboratory workers employed by the U.S. Department of Agriculture who died between January 1, 1970, and December 31, 1979. For males, the mortality odds ratio for all cancers was 1.0 (95% confidence interval = 0.8-1.2). Colon cancer, lymphosarcoma and reticulosarcoma, nonmalignant diseases of the blood and blood-forming organs, and suicide showed elevated mortality odds ratios. Only colon cancer showed an association with duration of employment as a laboratory worker. In an accompanying case-control study, the risk of colon cancer rose to 3.2 among those who had 20 or more years of employment as a laboratory worker. Among females, breast cancer was elevated (mortality odds ratio = 5.3; 95% confidence interval = 2.8-10.1). AS
KW  - laboratories
KW  - Laboratory workers
KW  - mortality
KW  - neoplasms
KW  - occupational medicine
KW  - workers
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - America (North)
KW  - cancers
KW  - death rate
KW  - Department of Agriculture
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020078&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - General and gene-specific DNA repair.
AU  - Snyderwine, E. G.
AU  - Bohr, V. A.
JO  - AgBiotech News and Information
JF  - AgBiotech News and Information
Y1  - 1992///
VL  - 4
IS  - 2
SP  - 45N
EP  - 52N
CY  - Wallingford; UK
PB  - CABI Publishing
AD  - Snyderwine, E. G.: Laboratory of Molecular Pharmacology, National Cancer Institute, Building 37-5C25, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 20063048161.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
N2  - DNA repair plays an important role in preventing the deleterious consequences of DNA damage. Deficiencies in DNA repair seen in certain hereditary disorders are associated with a predisposition to cancer. Recently, there have been some important advances in the field of DNA repair. One of them is the ability to study DNA damage and repair at the gene level. This led to the discovery of the intragenomic heterogeneity of DNA repair processes. This heterogeneity of DNA damage and repair is discussed in detail in this review, in the light of its importance in the molecular biology of DNA repair and the process of carcinogenesis.
KW  - carcinogenesis
KW  - carcinogens
KW  - DNA repair
KW  - genes
KW  - genomes
KW  - neoplasms
KW  - reviews
KW  - cancers
KW  - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063048161&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of Rickettsia rickettsii in saliva, haemolymph and triturated tissues of Dermacentor andersoni ticks by polymerase chain reaction.
AU  - Gage, K. L.
AU  - Gilmore, R. D.
AU  - Karstens, R. H.
AU  - Schwan, T. G.
JO  - Molecular and Cellular Probes
JF  - Molecular and Cellular Probes
Y1  - 1992///
VL  - 6
IS  - 4
SP  - 333
EP  - 341
SN  - 0890-8508
AD  - Gage, K. L.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950802700.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Diagnostic assays using polymerase chain reaction (PCR) were developed for identifying rickettsial infections in ticks. The assays amplified a 500 bp fragment from the gene encoding the rOMP B protein of R. rickettsii. The selected primers amplified fragments of the predicted size from all spotted fever group rickettsiae tested. No amplified products were detected when typhus group rickettsiae were assayed. Using techniques described in this study, the predicted product was reliably amplified from saliva, haemolymph and triturated tissues of D. andersoni. Samples derived from infected ticks preserved in 70% ethanol also were suitable for amplification by PCR, but similar assays performed with infected ticks preserved in 5% buffered formalin seldom gave positive results.
KW  - detection
KW  - disease vectors
KW  - polymerase chain reaction
KW  - Rocky Mountain spotted fever
KW  - tickborne diseases
KW  - Acari
KW  - Arachnida
KW  - Dermacentor andersoni
KW  - Ixodidae
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Dermacentor
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802700&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi.
AU  - Rosa, P. A.
AU  - Schwan, T.
AU  - Hogan, D.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992///
VL  - 6
IS  - 20
SP  - 3031
EP  - 3040
SN  - 0950-382X
AD  - Rosa, P. A.: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930517673.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Recombination between homologous genes encoding the major outer surface proteins (Osps) A and B of B. burgdorferi which both deletes osp gene sequences and creates chimaeric gene fusions is described. Recombinant osp genes occur in multiple strains and encode unique proteins that lack some characteristic Osp epitopes. Antigenic variation in Osp through recombination may be relevant to the persistence of B. burgdorferi in an infected host, and has important implications for the utility of OspA and OspB as diagnostic or vaccine candidates for Lyme disease. Also described is Osp variation arising from nonsense mutations and sequence divergence, which may also represent significant sources of Osp polymorphism.
KW  - Antigenic variation
KW  - Antigens
KW  - Chimaeras
KW  - genes
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - proteins
KW  - recombination
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - chimeras
KW  - DNA sequences
KW  - genetic recombination
KW  - immunogens
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517673&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Surface antigen variability and variation in Giardia lamblia.
AU  - Nash, T.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1992///
VL  - 8
IS  - 7
SP  - 229
EP  - 234
AD  - Nash, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930800327.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - This review of antigenic variation in Giardia deals with: heterogeneity among isolates; antigenic variation in vitro; antigenic variation in vivo; the nature of VSPs (variant-specific surface proteins; the control of antigenic variation).
KW  - Antigenic variation
KW  - antigens
KW  - Human diseases
KW  - parasites
KW  - Reviews
KW  - variation
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - Giardia lamblia
KW  - immunogens
KW  - surface
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930800327&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular detection of persistent Borrelia burgdorferi in a man with dermatomyositis.
AU  - Fraser, D. D.
AU  - Kong, L. I.
AU  - Miller, F. W.
JO  - Clinical and Experimental Rheumatology
JF  - Clinical and Experimental Rheumatology
Y1  - 1992///
VL  - 10
IS  - 4
SP  - 387
EP  - 390
SN  - 0392-856X
AD  - Fraser, D. D.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940501550.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A 40-year-old man with a several year history of various immunological disorders, including anti-Jo-1 autoantibody positive dermatomyositis, developed clinical Lyme disease after being bitten by a tick (in the USA). The patient was treated with oral tetracycline and his initial symptoms resolved; however, he suffered an exacerbation of his muscle disease which was difficult to control despite cytotoxic therapy. Antibiotic therapy was reinstituted after B. burgdorferi was detected in the patient's peripheral blood leukocytes by the polymerase chain reaction (PCR). All serologic, T-cell stimulation and Western blot analyses, however, were negative. The patient's disease responded to oral ampicillin, probenicid therapy and concurrent cytotoxic therapy. Subsequent leukocyte PCR testing has been negative for the causative agent of Lyme disease. This case may provide an example of the in vivo immuno-modulatory effects of spirochaetes in human autoimmune disease. In addition, this case emphasizes the potential clinical utility of PCR technology in evaluating the persistent sero-negative Lyme disease which may occur in immunocompromised individuals.
KW  - case reports
KW  - diagnosis
KW  - immunocompromised hosts
KW  - leukocytes
KW  - Lyme disease
KW  - polymerase chain reaction
KW  - rheumatism
KW  - USA
KW  - Borrelia burgdorferi
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - dermatomyositis
KW  - leucocytes
KW  - lyme borreliosis
KW  - PCR
KW  - United States of America
KW  - white blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940501550&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - Malaria transmission-blocking vaccines.
AU  - Kaslow, D. C.
AU  - Bathurst, I. C.
AU  - Barr, P. J.
JO  - Trends in Biotechnology
JF  - Trends in Biotechnology
Y1  - 1992///
VL  - 10
IS  - 11
SP  - 388
EP  - 391
SN  - 0167-7799
AD  - Kaslow, D. C.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19950805462.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology
N2  - The development of malaria transmission-blocking vaccines by targeting surface antigens of the sexual stages of Plasmodium falciparum is reviewed under the following headings: current malaria vaccine development; early extracellular sexual stage target antigens; Pfs25, a model for late sexual stage target antigens; Pfs25 expressed in recombinant vaccinia virus; Pfs25 expressed in yeast.
KW  - antigens
KW  - developmental stages
KW  - human diseases
KW  - immunization
KW  - live vaccines
KW  - malaria
KW  - parasites
KW  - reviews
KW  - surface antigens
KW  - vaccines
KW  - Apicomplexa
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - antigenicity
KW  - attenuated vaccines
KW  - growth phase
KW  - immune sensitization
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805462&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of immunity to parasites by T cells and T cell-derived cytokines.
AU  - Sher, A.
AU  - Coffman, R. L.
JO  - Annual Review of Immunology
JF  - Annual Review of Immunology
Y1  - 1992///
VL  - 10
SP  - 385
EP  - 409
SN  - 0732-0582
AD  - Sher, A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879433.  Publication Type: Journal Article.  Language: English.  Number of References: 133 ref. Subject Subsets: Protozoology; Helminthology
N2  - Current research on T-cell/parasite interactions is surveyed, with particular emphasis on those responses thought to play a functional role in immunity or immunopathology and on models that have provided general insights into the mechanisms governing T lymphocyte induction and regulation. The paper is organized around the roles of the different T-cell subsets and T-cell-mediated regulatory mechanisms in the immune response to parasites, rather than around a phylogenetic survey of different parasite genera. Topics discussed include regulation of cutaneous leishmaniasis by CD4+ T-cell subsets, immunity against the asexual blood stages of malaria, immunity against helminths, CD4+-dependent immunopathology, vaccine-induced immunity against Theileria parva in cattle, vaccine-induced immunity against pre-erythrocytic stages of malaria, resistance against Trypanosoma cruzi, protective immunity and control of reactivation in Toxoplasma gondii infection, immunoregulation by CD8+ lymphocytes, cross-regulation of CD4+ subsets by cytokines, cytokine inhibition of antiparasite effector responses and functions, and regulation by antiidiotypic T cells.
KW  - Cytokines
KW  - Helminths
KW  - Human diseases
KW  - immune response
KW  - Immunity
KW  - Parasites
KW  - reviews
KW  - T lymphocytes
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879433&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aerosolized pentamidine: a well-tolerated mode of prophylaxis against Pneumocystis carinii pneumonia in older children with human immunodeficiency virus infection.
AU  - Orcutt, T. A.
AU  - Godwin, C. R.
AU  - Pizzo, P. A.
AU  - Ognibene, F. P.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1992///
VL  - 11
IS  - 4
SP  - 290
EP  - 294
SN  - 0891-3668
AD  - Orcutt, T. A.: F.P. Ognibene, Critical Care Medicine Department, Building 10, Room 7D-43, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920881465.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 100-33-4, 140-64-7.  Subject Subsets: Protozoology
N2  - Aerosolized pentamidine as prophylaxis against Pneumocystis carinii pneumonia is described for the first time in children with HIV infection. The tolerance of monthly doses of aerosolized pentamidine (300 mg using the Respigard II nebulizer) was assessed in older children. During a 21-month period 22 patients (age range 3- 15 years; mean age 9.8 years ± 0.6 years) received a total of 185 treatments. 5 patients developed reversible bronchospasm requiring bronchodilators; no patients developed oxygen desaturation. None of these patients developed P. carinii pneumonia. The study suggests that aerosolized pentamidine as prophylaxis against P. carinii in older children is well tolerated.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - adverse effects
KW  - aerosols
KW  - children
KW  - clinical aspects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pentamidine
KW  - Pneumocystis carinii pneumonia
KW  - prophylaxis
KW  - Treatment
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - adverse reactions
KW  - AIDS
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881465&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis carinii and Mycobacterium avium-intracellulare infection of the choroid.
AU  - Whitcup, S. M.
AU  - Fenton, R. M.
AU  - Pluda, J. M.
AU  - Smet, M. D. de
AU  - Nussenblatt, R. B.
AU  - Chan, C. C.
JO  - Retina (Philadelphia)
JF  - Retina (Philadelphia)
Y1  - 1992///
VL  - 12
IS  - 4
SP  - 331
EP  - 335
SN  - 0275-004X
AD  - Whitcup, S. M.: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806612.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Protozoology
N2  - The case is reported of a 44-year-old man with AIDS and P. carinii choroiditis who was treated with iv trimethoprim and sulfamethoxazole, followed by iv trimethoprim and dapsone. The choroidal lesions failed to resolve in spite of 6 weeks treatment. The patient died from massive pulmonary infection caused by P. carinii, Mycobacterium avium-intracellulare and cytomegalovirus infections. Histology and electron microscopy revealed choroidal infection by both P. carinii and M. avium-intracellulare. It is thought that failure of the choroidal lesions of P. carinii to resolve may have been due to inadequate antimicrobial levels after the first week of treatment or the lack of infiltrating inflammatory cells in the choroid related to the patient's severe lymphopenia.
KW  - acquired immune deficiency syndrome
KW  - case reports
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - interactions
KW  - mixed infections
KW  - opportunistic infections
KW  - parasites
KW  - Maryland
KW  - North America
KW  - USA
KW  - bacteria
KW  - man
KW  - Mycobacterium avium complex
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - prokaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - bacterium
KW  - fungus
KW  - human immunodeficiency virus
KW  - multiple infections
KW  - Mycobacterium avium-intracellulare
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806612&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of epidemic infectious diseases in the discovery of America.
AU  - Bianchine, P. J.
AU  - Russo, T. A.
JO  - Allergy Proceedings
JF  - Allergy Proceedings
Y1  - 1992///
VL  - 13
IS  - 5
SP  - 225
EP  - 232
AD  - Bianchine, P. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930516872.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The role of diseases such as smallpox, measles, louse-borne typhus, yellow fever and malaria in the European conquest of the Americas is discussed.
KW  - History
KW  - human diseases
KW  - Malaria
KW  - Measles
KW  - Smallpox
KW  - Yellow fever
KW  - America
KW  - Caribbean
KW  - Central America
KW  - North America
KW  - America
KW  - Souh America
KW  - Typhus
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930516872&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Successful treatment of systemic Exophiala dermatitidis infection in a patient with chronic granulomatous disease.
AU  - Kenney, R. T.
AU  - Kwon-Chung, K. J.
AU  - Waytes, A. T.
AU  - Melnick, D. A.
AU  - Pass, H. I.
AU  - Merino, M. J.
AU  - Gallin, J. I.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 14
IS  - 1
SP  - 235
EP  - 242
SN  - 1058-4838
AD  - Kenney, R. T.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211980.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 65277-42-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 21-yr-old woman with autosomal recessive chronic granulomatous disease of childhood who was found to have a progressive pulmonary and central nervous system infection with E. [Wangiella] dermatitidis. The patient responded to an aggressive, multifaceted therapeutic approach involving surgical resection of the pulmonary source and medical therapy with amphotericin B (total dose 2 g), flucytosine (500 mg 4 times daily) or ketoconazole (200 mg/d), and transfused white cells, followed by a prolonged course of fluconazole (2 yrs).
KW  - amphotericin B
KW  - Antifungal agents
KW  - fluconazole
KW  - flucytosine
KW  - generalized infections
KW  - hosts
KW  - infections
KW  - ketoconazole
KW  - predisposition
KW  - therapy
KW  - USA
KW  - Exophiala dermatitidis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Herpotrichiellaceae
KW  - Chaetothyriales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Exophiala
KW  - 5-fluorocytosine
KW  - chronic granulomatous disease
KW  - fungistats
KW  - fungus
KW  - therapeutics
KW  - United States of America
KW  - Wangiella
KW  - Wangiella dermatitidis
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vascular catheter-associated fungemia in patients with cancer: analysis of 155 episodes.
AU  - Lecciones, J. A.
AU  - Lee, J. W.
AU  - Navarro, E. E.
AU  - Witebsky, F. G.
AU  - Marshall, D.
AU  - Steinberg, S. M.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 14
IS  - 4
SP  - 875
EP  - 883
SN  - 1058-4838
AD  - Lecciones, J. A.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921212027.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A total of 155 episodes of central venous catheter-associated fungaemia among inpatients at the National Cancer Institute, Maryland, during a 10-yr period were reviewed. Candida spp. (C. albicans, C. tropicalis, C. parapsilosis, C. [Torulopsis] glabrata, C. lusitaniae, C. guilliermondii, C. krusei and C. pseudotropicalis [C. kefyr]) accounted for 98% of episodes; Malassezia furfur and Saccharomyces cerevisiae were isolated from one case each. Fungaemia was documented by culture of blood drawn through catheters in 50% of cases and by culture of both catheter-drawn and peripheral blood in 39%; mortality and the rate of dissemination were similar for these 2 groups. Four management strategies were used: catheter removal, antifungal therapy (with amphotericin B), both or neither; indications for the use of both modes of treatment included fever, neutropenia, long-term indwelling catheterization, positive cultures of both catheter-drawn and peripheral blood, isolation of C. tropicalis and fungal isolation from 2 or more blood cultures. Disseminated fungal infection was documented in 82% of cases with these features but also in 35% of the less severe cases treated only with catheter removal. In addition, 9 (82%) of 11 cases managed only with antifungal therapy had a negative outcome (either death from disseminated infection or the recurrence of fevers and/or fungaemia), suggesting that intravascular catheters should be removed in fungaemia. It is concluded that virtually all cases of catheter-associated fungaemia in patients with cancer are clinically significant and require prompt therapy with amphotericin B.
KW  - blood
KW  - catheters
KW  - hosts
KW  - infections
KW  - neoplasms
KW  - predisposition
KW  - USA
KW  - Blastodendrion arztii
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida kefyr
KW  - Candida lusitaniae
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - Malassezia furfur
KW  - man
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Malassezia
KW  - Malasseziales
KW  - Ustilaginomycotina
KW  - Basidiomycota
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Torulopsis
KW  - Pezizomycotina
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Blastodendrion
KW  - cancers
KW  - Candida guilliermondii
KW  - Candida krusei
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prophylaxis for Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus.
AU  - Kovacs, J. A.
AU  - Masur, H.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 14
IS  - 5
SP  - 1005
EP  - 1009
SN  - 1058-4838
AD  - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930883359.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 100-33-4, 140-64-7.  Subject Subsets: Protozoology
N2  - Following the initial observation that trimethoprim- sulfamethoxazole can prevent Pneumocystis carinii pneumonia (PCP) in HIV positive patients with Kaposi's sarcoma, initiating prophylaxis for PCP infection in all patients with &lt;200 CD4 cells/mm³ has become accepted practice. This prophylactic intervention has been found not only to reduce the development of PCP but also to prolong life. The authors of this AIDS commentary first reviewed prophylaxis for PCP 3 years ago. This article updates their review, placing currently available information into clinical perspective and outlining a plan for the clinician to follow based on recent studies.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - aerosols
KW  - antiprotozoal agents
KW  - clinical aspects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pentamidine
KW  - Pneumocystis carinii pneumonia
KW  - prophylaxis
KW  - reviews
KW  - Treatment
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - trimethoprim sulfamethoxazole
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883359&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Successful treatment of Paecilomyces variotii infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections.
AU  - Williamson, P. R.
AU  - Kwon-Chung, K. J.
AU  - Gallin, J. I.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 14
IS  - 5
SP  - 1023
EP  - 1026
SN  - 1058-4838
AD  - Williamson, P. R.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921212077.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 1397-89-3, 84625-61-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in an 8-yr-old boy with chronic granulomatous disease who developed a soft tissue infection of the right heel after riding on a motor scooter. Infection was insidious, and minor heel pain and fevers occurred only on the day interferon-γ was injected. Soft tissue biopsy showed hyphal elements and P. variotii grew in culture. The infection was treated with amphotericin B for 7 wks (total dose 40 mg/kg) followed by 1 yr of therapy with itraconazole (100 mg twice daily). Complete cure was achieved during the follow-up period of 10 months. Previously reported cases of infection caused by Paecilomyces spp. are reviewed.
KW  - amphotericin B
KW  - Antifungal agents
KW  - hosts
KW  - infections
KW  - itraconazole
KW  - predisposition
KW  - therapy
KW  - USA
KW  - man
KW  - Paecilomyces variotii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Paecilomyces
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chronic granulomatous disease
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212077&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Experimental antifungal chemotherapy in granulocytopenic animal models of disseminated candidiasis: approaches to understanding investigational antifungal compounds for patients with neoplastic diseases.
AU  - Walsh, T. J.
AU  - Lee, J. W.
AU  - Roilides, E.
AU  - Francis, P.
AU  - Bacher, J.
AU  - Lyman, C. A.
AU  - Pizzo, P. A.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 14
IS  - Suppl. 1
SP  - S139
EP  - S147
SN  - 1058-4838
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921212103.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 59 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 84625-61-6, 79404-91-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - A review of recent approaches to pre-clinical laboratory investigation of promising antifungal compounds, which may have potential utility in granulocytopenic patients is presented. A particularly useful strategy is the study of persistently granulocytopenic rabbit models of acute, subacute, and chronic forms of disseminated Candida albicans infection. When the antifungal triazoles (fluconazole, itraconazole, and SCH 39304) were each evaluated for use as preventive, early treatment, or delayed treatment in the different models, the triazoles were consistently more active when used for preventive and early treatment than for delayed treatment. These triazoles were as active as amphotericin B plus flucytosine (AB + FC) when used for early treatment but were less active than AB + FC when used for delayed treatment. Several lipid formulations of amphotericin B demonstrate reduced nephrotoxicity at higher safely achievable dosages in comparison to those of deoxycholate amphotericin B in several models of disseminated candidosis. When administered to follow non-linear saturable Michaelis-Menten-type plasma pharmacokinetics, the antifungal activity of cilofungin was significantly augmented. It is concluded that thoughtfully designed and carefully conducted laboratory investigations in appropriate animal models of disseminated candidosis can provide a scientific foundation and guide for development of clinical protocols investigating new approaches to prevention and treatment of invasive candidosis in granulocytopenic patients.
KW  - amphotericin B
KW  - Antifungal agents
KW  - cilofungin
KW  - fluconazole
KW  - flucytosine
KW  - infections
KW  - itraconazole
KW  - predisposition
KW  - therapy
KW  - Candida albicans
KW  - Rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - 5-fluorocytosine
KW  - Focus on fungal infections, an update on diagnosis and treatment
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - SCH 39304
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212103&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Emergence of unusual opportunistic pathogens in AIDS: a review.
AU  - Gradon, J. D.
AU  - Timpone, J. G.
AU  - Schnittman, S. M.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 15
IS  - 1
SP  - 134
EP  - 157
SN  - 1058-4838
AD  - Gradon, J. D.: Medical Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD 20892, USA.
N1  - Accession Number: 19921212511.  Publication Type: Journal Article.  Language: English.  Number of References: 160 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - Unusual opportunistic pathogens emerging in AIDS patients are extensively reviewed. Organisms causing pulmonary infections, skin and soft-tissue lesions, infections of the nervous system, disseminated infections due to fungi such as Penicillium marneffei, Histoplasma capsulatum, Sporobolomyces salmonicolor, Fusarium spp., Aureobasidium pullulans and Pseudallescheria boydii, due to Pneumocystis carinii, bacteria, viruses, Leishmania donovani and disseminated microsporidial infections, joint infections, infections of the head, gastrointestinal tract and cardiac abnormalities are discussed.
KW  - acquired immune deficiency syndrome
KW  - clinical aspects
KW  - databases
KW  - HIV infections
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Information
KW  - Mycoses
KW  - Opportunistic infections
KW  - parasites
KW  - predisposition
KW  - reviews
KW  - Leishmania donovani
KW  - Man
KW  - Microspora
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - AIDS
KW  - clinical picture
KW  - Computer search
KW  - data banks
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Unusual opportunistic pathogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212511&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cutaneous leishmaniasis: review of 59 cases seen at the National Institutes of Health.
AU  - Melby, P. C.
AU  - Kreutzer, R. D.
AU  - McMahon-Pratt, D.
AU  - Gam, A. A.
AU  - Neva, F. A.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 15
IS  - 6
SP  - 924
EP  - 937
SN  - 1058-4838
AD  - Melby, P. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19930883174.  Publication Type: Journal Article.  Language: English.  Number of References: 103 ref. Subject Subsets: Protozoology
N2  - Fifty-nine cases of cutaneous leishmaniasis seen at the National Institutes of Health in Bethesda, USA, are reviewed. This group of patients was unique in that the majority were American civilians, their disease was acquired in many parts of the world, and their illnesses represented all points on the clinical spectrum of cutaneous disease. Cutaneous disease acquired in the New World usually consisted of one or two lesions, while multiple lesions often characterized Old World infections with Leishmania major. Patients with chronic relapsing or diffuse cutaneous leishmaniasis were native to endemic areas and were infected at an early age. Diagnosis with culture and identification of the parasite was instrumental in the selection of optimal therapy.
KW  - cutaneous leishmaniasis
KW  - human diseases
KW  - imported infections
KW  - parasites
KW  - reviews
KW  - Maryland
KW  - North America
KW  - USA
KW  - Leishmania
KW  - Leishmania major
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883174&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics and antifungal therapy.
AU  - Francis, P.
AU  - Walsh, T. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1992///
VL  - 15
IS  - 6
SP  - 1003
EP  - 1018
SN  - 1058-4838
AD  - Francis, P.: T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931213788.  Publication Type: Journal Article.  Language: English.  Number of References: 117 ref. Registry Number: 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety and tolerability of flucytosine was evaluated in 17 patients with cancer or aplastic anaemia during a 2.5-yr period. The combination of amphotericin B plus flucytosine eradicated mycosis (due to Candida albicans, Aspergillus, Torulopsis glabrata, C. guilliermondii, C. tropicalis, Cryptococcus neoformans) in 12 (71%) of 17 patients, whereas 3 (18%) of 17 died of progressive fungal infection (due to Candida tropicalis or A. fumigatus). Serial serum levels of flucytosine measured by a creatinine iminohydrolase assay permitted reliable dosage adjustment. During therapy, only 2 (12%) of 17 patients had elevated mean serum levels of flucytosine (&gt;100 µg/ml) and 3 (18%) other patients had transiently elevated levels. Paired serum samples (n=45) obtained at steady state during therapy with orally administered flucytosine showed similar peak and trough levels. Adverse effects of flucytosine therapy included 1 case each of reversible nausea, diarrhoea, elevated transaminase levels and thrombocytopenia. No cases of bone marrow aplasia, enterocolitis, hepatitis or death due to flucytosine toxicity were encountered. It is concluded that flucytosine in combination with amphotericin B is well tolerated in myelosuppressed patients when serum flucytosine levels are serially monitored. The mechanism of action, mechanism of resistance, in vitro and in vivo antifungal activity, clinical antifungal activity, pharmacokinetics and toxicity of flucytosine are also reviewed.
KW  - Antifungal agents
KW  - Flucytosine
KW  - hosts
KW  - immunosuppression
KW  - infections
KW  - predisposition
KW  - reviews
KW  - therapy
KW  - USA
KW  - Aspergillus
KW  - Aspergillus fumigatus
KW  - Blastodendrion arztii
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida parapsilosis
KW  - Cryptococcus neoformans
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Aspergillus
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Torulopsis
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Blastodendrion
KW  - 5-fluorocytosine
KW  - Candida guilliermondii
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Torulopsis glabrata
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931213788&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resting metabolic rate and body composition of Pima Indian and Caucasian children.
AU  - Fontvieille, A. M.
AU  - Dwyer, J.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1992///
VL  - 16
IS  - 8
SP  - 535
EP  - 542
SN  - 0307-0565
AD  - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19931465431.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - Body composition (bioelectrical resistance) and resting metabolic rate (RMR) were estimated in 43 Pima Indian children (mean age ±s.d. 9.9±1.1) and 42 Caucasian children (9.7±1.2 years old). Pima children were taller (143±9 vs. 137±8 cm, P &lt;0.001), heavier (48.6±15.8 vs. 32.9±7.8 kg, P &lt;0.001) and fatter (39±10 vs. 24±7% fat, P &lt;0.001) than Caucasians. Absolute values of RMR were higher in Pimas than in Caucasians (6234±1201 vs. 5171±715 kJ/day, P &lt;0.001), but similar when adjusted for differences in body size, body composition and sex. A decreased RMR in Pima as compared to Caucasian children was not found. Therefore, the high prevalence of obesity in Pima children at 10 years old suggested that excess energy intake and/or low levels of physical activity was the major aetiological factor, though the possibility that a low metabolic rate might be a predisposing factor at an earlier age was not discounted.
KW  - body composition
KW  - children
KW  - ethnic groups
KW  - metabolism
KW  - obesity
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465431&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for independent genetic influences on obesity in middle age.
AU  - Fabsitz, R. R.
AU  - Carmelli, D.
AU  - Hewitt, J. K.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1992///
VL  - 16
IS  - 9
SP  - 657
EP  - 666
SN  - 0307-0565
AD  - Fabsitz, R. R.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19931465752.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - The relative contribution of genes and environmental factors to obesity throughout adulthood was assessed. Data from the National Heart, Lung and Blood Institute Twin Study (USA) was used and analyses of obesity were performed on 124 pairs of monozygotic and and 119 pairs of dizygotic white male twins with complete data for 4 examinations spanning a 43-year period of adult life. Genetic, shared environment and non-shared environment contributions to body mass index were estimated.
KW  - age
KW  - body measurements
KW  - body weight
KW  - genetics
KW  - genotype nutrition interaction
KW  - obesity
KW  - twins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465752&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging.
AU  - Seidell, J. C.
AU  - Muller, D. C.
AU  - Sorkin, J. D.
AU  - Andres, R.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1992///
VL  - 16
IS  - 9
SP  - 667
EP  - 674
SN  - 0307-0565
AD  - Seidell, J. C.: Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
N1  - Accession Number: 19931465745.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Human Nutrition
N2  - 775 men, 18 to 98 years old, participating in the Baltimore Longitudinal Study on Aging (USA) were followed for an average of 10 years. Resting metabolic rate (RMR) and fasting respiratory exchange ratio (RER) were measured by indirect calorimetry on their 1st visit and related to subsequent weight change. Deviations from the predicted value of RMRs (predicted from their estimated fat-free mass) were calculated. Average weight change was 0.07 kg (s.d. 6.4); 122 men (15.3%) gained &gt;5 kg and 40 (5.2%) &gt;10 kg during the follow-up. After adjustment for initial age, body mass index, fat-free mass, and duration of follow-up, RER, but not RMR or deviations from predicted RMR, was positively related to weight change (P&lt;0.001). Major weight gain (from at least 5 to at least 15 kg) was related to initial RER in non-obese men only (initial BMI &lt;25 kg/m²). From Cox proportional hazard regression analyses the adjusted relative risk of gaining 5 kg or more in initially non-obese men with a fasting RER of ≥0.85 was calculated to be 2.42 (95% confidence interval: 1.10-5.32) compared with men with a fasting RER &lt;0.76. It is concluded that a relatively high fasting RER is a weak but significant predictor of substantial weight gain in non-obese white men.
KW  - aging
KW  - body weight
KW  - energy exchange
KW  - men
KW  - metabolism
KW  - respiration
KW  - respiratory quotient
KW  - resting energy exchange
KW  - weight gain
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - ageing
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465745&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokines and their role in the pathophysiology of cancer cachexia.
AU  - McNamara, M. J.
AU  - Alexander, R.
AU  - Norton, J. A.
JO  - Journal of Parenteral and Enteral Nutrition
JF  - Journal of Parenteral and Enteral Nutrition
Y1  - 1992///
VL  - 16
IS  - Suppl. 6
SP  - 50S
EP  - 55S
SN  - 0148-6071
AD  - McNamara, M. J.: J. A. Norton, Surgical Metabolism Section, Surgery Branch, National Cancer Institute, NIH, Bldg 10, Room 2B07, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931461457.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 62 ref. Registry Number: 9008-11-1.  Subject Subsets: Human Nutrition
N2  - The role of cytokines (tumour necrosis factor, interleukin-1, interleukin-6, interferon-γ and differentiation factor) in the pathophysiology of neoplasm cachexia is reviewed.
KW  - cachexia
KW  - interferon
KW  - interleukins
KW  - Neoplasms
KW  - reviews
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - American Society for Parenteral and Enteral Nutrition
KW  - cancers
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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ER  - 

TY  - JOUR
T1  - Mortality of workers employed at organochlorine pesticide manufacturing plants - an update.
AU  - Brown, D. P.
JO  - Scandinavian Journal of Work, Environment & Health
JF  - Scandinavian Journal of Work, Environment & Health
Y1  - 1992///
VL  - 18
IS  - 3
SP  - 155
EP  - 161
SN  - 0355-3140
AD  - Brown, D. P.: Office of Occupational Health and Technical Services, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19930514537.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 309-00-2, 57-74-9, 12789-03-6, 50-29-3, 60-57-1, 72-20-8, 76-44-8.  Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology; Public Health
N2  - A previous mortality study among 4 organochlorine pesticide manufacturers in the USA [see D. Ditraglia et al. (1981) Scandinavian Journal of Work, Environment & Health, 7 (Suppl. 4): 140-146] was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and DDT. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (5 observed, standardized mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumours of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumours, and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A previous mortality study among four organochlorine pesticide manufacturers was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and dichlorodiphenyltrichloroethane. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (5 observed, standardized mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumours of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumours, and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer. AS
KW  - agricultural entomology
KW  - Aldrin
KW  - Carcinogens
KW  - Carcinoma
KW  - Chlordane
KW  - DDT
KW  - Dieldrin
KW  - Endrin
KW  - Epidemiology
KW  - exposure
KW  - Heptachlor
KW  - Human diseases
KW  - insecticides
KW  - liver
KW  - mortality
KW  - Neoplasms
KW  - Nontarget effects
KW  - Occupational hazards
KW  - occupational medicine
KW  - occupations
KW  - organochlorine compounds
KW  - Organochlorine insecticides
KW  - Pesticides
KW  - poisoning
KW  - Toxicity
KW  - workers
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - America (North)
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - dicophane
KW  - Heptachor
KW  - organchlorine manufacturers
KW  - organic chlorine compounds
KW  - toxicosis
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Occupational Health and Safety (VV900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Clues to cancer etiology from studies of farmers.
AU  - Blair, A.
AU  - Zahm, S. H.
AU  - Pearce, N. E.
AU  - Heineman, E. F.
AU  - Fraumeni, J. F., Jr.
JO  - Scandinavian Journal of Work, Environment & Health
JF  - Scandinavian Journal of Work, Environment & Health
Y1  - 1992///
VL  - 18
IS  - 4
SP  - 209
EP  - 215
SN  - 0355-3140
AD  - Blair, A.: National Cancer Institute, Executive Plaza North, Room 418, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020032.  Publication Type: Journal Article.  Language: English.  Number of References: 79 ref. Subject Subsets: Public Health
KW  - aetiology
KW  - agriculture
KW  - exposure
KW  - farm workers
KW  - farmers
KW  - neoplasms
KW  - occupations
KW  - pesticides
KW  - research
KW  - reviews
KW  - workers
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancer research
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - studies
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Research (AA500) 
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ER  - 

TY  - JOUR
T1  - Phenylalkenals in ponerine (Leptogenys sp.) and myrmicine (Pogonomyrmex sp.) ants.
AU  - Fales, H. M.
AU  - Jones, T. H.
AU  - Jaouni, T.
AU  - Blum, M. S.
AU  - Schmidt, J. O.
JO  - Journal of Chemical Ecology
JF  - Journal of Chemical Ecology
Y1  - 1992///
VL  - 18
IS  - 6
SP  - 847
EP  - 854
SN  - 0098-0331
AD  - Fales, H. M.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941102529.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Agricultural Entomology; Medical & Veterinary Entomology
N2  - Cephalic extracts of 2 unrelated species of formicid, Leptogenys processionalis and Pogonomyrmex rugosus, contained 2-phenylpropenal and 2-phenyl-2-butenal, while 2 other species related to L. processionalis, L. chinensis and L. kitteli, lacked either. L. kitteli also produced a tetrasubstituted pyrazine found previously only in 2 New Zealand ants in the genus Mesoponera. The chemical reactivity of the phenylalkenals suggested that their function was to repel attacks by predators.
KW  - agricultural entomology
KW  - animal physiology
KW  - Behaviour
KW  - biochemistry
KW  - Biology
KW  - Chemical composition
KW  - defensive secretions
KW  - Insect pests
KW  - Natural enemies
KW  - predators
KW  - Predatory insects
KW  - Pyrazines
KW  - secretions
KW  - Social insects
KW  - New Zealand
KW  - arthropods
KW  - Formicidae
KW  - Hymenoptera
KW  - insects
KW  - Pogonomyrmex rugosus
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - Pogonomyrmex
KW  - Formicidae
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - 2-Phenyl-2-butenal
KW  - 2-Phenylpropenal
KW  - behavior
KW  - Leptogenys
KW  - Leptogenys chinensis
KW  - Leptogenys kitteli
KW  - Leptogenys processionalis
KW  - Mesoponera
KW  - pest insects
KW  - Phenylalkenals
KW  - predaceous insects
KW  - predacious insects
KW  - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW  - Biological Control (HH100) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Chemistry (ZZ600) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
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ER  - 

TY  - GEN
T1  - Three fatal cases of disseminated mucormycosis associated with respiratory distress syndrome and shock in patients with hematologic malignancies.
AU  - Agh, F.
AU  - Spanik, S.
AU  - Gyarfas, J.
AU  - Horváth, J.
AU  - Krčméry, V., Jr.
T2  - Infection
JO  - Infection
JF  - Infection
Y1  - 1992///
VL  - 20
IS  - 2
SP  - 112
EP  - 112
SN  - 0300-8126
AD  - Agh, F.: National Cancer Institute, 83310 Bratislava, Czechoslovakia.
N1  - Accession Number: 19921212274.  Publication Type: Correspondence.  Language: English.  Number of References: 2 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Three fatal cases of pulmonary zygomycosis are reported in patients (68-, 42- and 54-yr-old men) with leukaemia and lymphoma. All patients suffered neutropenia and were treated with steroids. The clinical course was rapid in each case and was associated with septic shock, acute respiratory, renal and hepatic failure. Within 72 h of X-rays revealing the first signs of pneumonia, the patients died. At autopsy, disseminated infections were found in all cases. Mucor sp. was identified in 2 cases.
KW  - generalized infections
KW  - hosts
KW  - infections
KW  - lungs
KW  - neoplasms
KW  - predisposition
KW  - ZYGOMYCOSIS
KW  - Czechoslovakia
KW  - man
KW  - Mucor
KW  - Mucoraceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mucoraceae
KW  - Mucorales
KW  - Mucoromycotina
KW  - Zygomycota
KW  - fungi
KW  - Central Europe
KW  - Europe
KW  - cancers
KW  - fungus
KW  - phycomycosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for epithelial ovarian cancer in Beijing, China.
AU  - Chen, Y.
AU  - Wu, P. C.
AU  - Lang, J. H.
AU  - Ge, W. J.
AU  - Hartge, P.
AU  - Brinton, L. A.
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1992///
VL  - 21
IS  - 1
SP  - 23
EP  - 29
SN  - 0300-5771
AD  - Chen, Y.: (L.A. Brinton) Executive Plaza North, Rm. 443, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021486.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The results of a case-control study (112 cases) "suggest that Chinese women have risk factors similar to those of occidental women."
KW  - epithelium
KW  - female genitalia
KW  - genitalia
KW  - neoplasms
KW  - ovaries
KW  - risk factors
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - female genital system
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of dietary intake of fruits and vegetables on the odds ratio of lung cancer among Yunnan tin miners.
AU  - Forman, M. R.
AU  - Yao, S. X.
AU  - Graubard, B. I.
AU  - Qiao, Y. L.
AU  - McAdams, M.
AU  - Mao, B. L.
AU  - Taylor, P. R.
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1992///
VL  - 21
IS  - 3
SP  - 437
EP  - 441
SN  - 0300-5771
AD  - Forman, M. R.: Cancer Prevention Studies Branch, CPRP, DCPC, National Cancer Institute, Executive Plaza North, Room 211C, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931458830.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Human Nutrition
N2  - All newly diagnosed patients with lung cancer (n = 183) among male tin miners of Yunnan Province, China in 1985-86 and age-sex matched occupational controls (n = 183 aged 45-79 years) were interviewed. The cancer patients were interviewed within 3 months of diagnosis. The questionnaire included information about the diet as well as employment and smoking histories. Over 95% of cases and controls were current smokers. The 27-item food frequency questionnaire included 11 fruits and vegetables rich in vitamin A and/or carotenoids. The effect of dietary intake of fruits and vegetables on risk of lung cancer was examined with adjustments for exposures to radon, arsenic and smoking as previously documented risk factors for lung cancer. Tin miners with reduced intake of yellow and light green vegetables had significantly increased odds ratios (OR) of lung cancer (OR = 2.26 and 2.39 for the lowest 2 quartiles of intake; P = 0.02) among cases compared with controls after multiple logistic regression adjustment for covariates, and this relationship was monotonic. Tin miners with reduced intake of tomatoes had significantly increased adjusted OR of lung cancer (OR = 2.64, 3.09 and 2.36 for the 3 lowest quartiles of intake; P value for trend = 0.04). This is the first study to demonstrate a protective effect of vegetable intake against the strong carcinogenic effects of smoking and occupational exposure.
KW  - Carcinoma
KW  - fruit
KW  - intake
KW  - lungs
KW  - vegetables
KW  - China
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - People's Republic of China
KW  - vegetable crops
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Experimental models of immunization against schistosomes: lessons for vaccine development.
AU  - James, S. L.
JO  - Immunological Investigations
JF  - Immunological Investigations
Y1  - 1992///
VL  - 21
IS  - 5
SP  - 477
EP  - 493
SN  - 0882-0139
AD  - James, S. L.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930802155.  Publication Type: Journal Article.  Language: English.  Number of References: 69 ref. Subject Subsets: Helminthology
N2  - Experimental models of immunization against Schistosoma are discussed under the headings: attenuated vaccine models; activated macrophages as immune effector cells; hyperimmunization with attenuated parasites; non-living vaccine models; candidate vaccine antigens. Lessons for vaccine development are proposed.
KW  - disease models
KW  - helminths
KW  - immunization
KW  - Laboratory animals
KW  - parasites
KW  - reviews
KW  - Schistosomiasis
KW  - Vaccines
KW  - Digenea
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - immune sensitization
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Catheter-associated septicaemia due to Trichosporon capitatum.
AU  - Syčova-Milá, Z.
AU  - Sufliarsky, J.
AU  - Trupl, J.
AU  - Jasenská, Z.
AU  - Blahvá, M.
AU  - Krčméry, V., Jr.
T2  - Journal of Hospital Infection
JO  - Journal of Hospital Infection
JF  - Journal of Hospital Infection
Y1  - 1992///
VL  - 22
IS  - 3
SP  - 257
EP  - 258
SN  - 0195-6701
AD  - Syčova-Milá, Z.: Department of Clinical Oncology, National Cancer Institute, Klenova 3, 83310 Bratislava, Slovakia.
N1  - Accession Number: 19931215041.  Publication Type: Correspondence.  Language: English.  Number of References: 8 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case of fungaemia is reported in a 23-yr-old woman with Hodgkin's disease, who developed neutropenia and fever after chemotherapy. After 3 d, a subclavian catheter was inserted. The fever did not respond to antibiotic treatment. Blood and catheter cultures grew T. capitatum [Blastoschizomyces capitatus] and intravenous amphotericin B (35 mg/d) and oral flucytosine (2 g/d) were administered. Blood samples remained positive for 11 d after the start of amphotericin B therapy and the catheter was removed. Cultures were negative on days 12, 14 and 15, and after 24 d of amphotericin B (total dose 0.8 g), the fever resolved.
KW  - blood
KW  - catheters
KW  - hosts
KW  - infections
KW  - predisposition
KW  - Slovakia
KW  - man
KW  - Trichosporon capitatum
KW  - Blastoschizomyces
KW  - Dipodascaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Blastoschizomyces capitatus
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β.
AU  - Gazzinelli, R. T.
AU  - Oswald, I. P.
AU  - Hieny, S.
AU  - James, S. L.
AU  - Sher, A.
JO  - European Journal of Immunology
JF  - European Journal of Immunology
Y1  - 1992///
VL  - 22
IS  - 10
SP  - 2501
EP  - 2506
SN  - 0014-2980
AD  - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950802486.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 74-79-3, 9008-11-1, 130068-27-8, 10102-43-9, 76057-06-2.  Subject Subsets: Protozoology; Tropical Diseases
N2  - The mechanism of anti-Trypanosoma cruzi activity by interferon (IFN)-γ plus lipopolysaccharide (LPS)-treated macrophages was investigated. A macrophage cell line (IC-21) that failed to produce an appreciable oxidative burst was able to control T. cruzi growth after exposure to IFN-γ alone or IFN-γ plus LPS. Microbicidal functions of both inflammatory macrophages and IC-21 against T. cruzi were inhibited by NG-monomethyl-L-arginine (NGMMA), a competitive inhibitor of L-arginine. Addition of supplemental L-arginine to the culture overcame the capacity of NGMMA to block activated macrophage anti-T. cruzi functions. The ability of NGMMA to reverse both parasite growth inhibition and killing by IFN-γ plus LPS-activated macrophages was correlated with the suppression of nitrite accumulation in culture supernatants. The results implicate the L-arginine-dependent production of nitric oxide in T. cruzi killing by activated macrophages. Both interleukin (IL)-10 and transforming growth factor (TGF)-β inhibited anti-parasite function by IFN-γ-activated macrophages, with optimal doses of 100 units/ml and 0.5 ng/ml, respectively. When used in combination, suboptimal doses of IL-10 and TGF-β produced a synergistic inhibitory effect on the regulation of T. cruzi growth. The ability of IL-10 and TGF-β to suppress microbicidal function was positively correlated with the inhibition of nitrite generation in macrophage culture supernatants. The results predict an in vivo role for IL-10 and TGF-β in promoting parasite survival against the host immune response.
KW  - arginine
KW  - immune response
KW  - in vitro
KW  - interferon
KW  - interleukin 10
KW  - lipopolysaccharides
KW  - macrophages
KW  - nitric oxide
KW  - parasites
KW  - transforming growth factor
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - activated
KW  - growth regulation
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differentiation of pathogenic Entamoeba histolytica from other intestinal protozoa by riboprinting.
AU  - Clark, C. G.
AU  - Diamond, L. S.
JO  - Archives of Medical Research
JF  - Archives of Medical Research
Y1  - 1992///
VL  - 23
IS  - 2
SP  - 15
EP  - 16
SN  - 0066-6769
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803769.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Subject Subsets: Protozoology
N2  - Differentiation of the pathogen Entamoeba histolytica from the variety of other amoebae that can infect the human intestinal tract is vital for accurate diagnosis and treatment. Morphology and serology alone are not adequate for positive identification to be achieved. In this study, methods were developed using polymerase chain reaction to amplify amoebic ribosomal RNA genes that allowed either specific detection of E. histolytica or species identification.
KW  - amoebiasis
KW  - chemotaxonomy
KW  - gastrointestinal diseases
KW  - genes
KW  - human diseases
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - restriction mapping
KW  - ribosomal RNA
KW  - Blastocystis hominis
KW  - Endamoebidae
KW  - Endolimax nana
KW  - Entamoeba coli
KW  - Entamoeba hartmanni
KW  - Entamoeba histolytica
KW  - Entamoeba moshkovskii
KW  - protozoa
KW  - Sarcomastigophora
KW  - Blastocystis
KW  - Amoebida incertae sedis
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Endolimax
KW  - Endamoebidae
KW  - Entamoeba
KW  - amebiasis
KW  - biochemical genetics
KW  - biochemical taxonomy
KW  - PCR
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803769&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Amebiasis: a problem solved. What now ?
AU  - Diamond, L. S.
JO  - Archives of Medical Research
JF  - Archives of Medical Research
Y1  - 1992///
VL  - 23
IS  - 4
SP  - 157
EP  - 161
SN  - 0066-6769
AD  - Diamond, L. S.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803424.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - In this review, the well documented fact that only 10% of those infected with Entamoeba histolytica develop invasive disease is examined. In attempting to explain this phenomenon it is stated that the evidence that there are 2 morphologically identical but nevertheless distinctly different species (E. histolytica and E. dispar) involved is indisputable. They can be separated by biochemical, immunological and genetic criteria. The importance of recognizing the 2 species and the impact of this on the interpretation of epidemiological data is discussed.
KW  - Amoebiasis
KW  - human diseases
KW  - parasites
KW  - pathogenicity
KW  - reviews
KW  - Entamoeba dispar
KW  - Entamoeba histolytica
KW  - man
KW  - protozoa
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - amebiasis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803424&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The fat and fiber content of foods: what Americans know.
AU  - Cremer, S. A.
AU  - Kessler, L. G.
JO  - Journal of Nutrition Education
JF  - Journal of Nutrition Education
Y1  - 1992///
VL  - 24
IS  - 3
SP  - 149
EP  - 152
SN  - 0022-3182
AD  - Cremer, S. A.: National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951401687.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
KW  - composition
KW  - fats
KW  - fibre
KW  - foods
KW  - nutrition knowledge
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fiber
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Food Composition and Quality (QQ500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401687&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of the anorectic drug recognition site during glucoprivic feeding.
AU  - Angel, I.
AU  - Hauger, R. L.
AU  - Giblin, B. A.
AU  - Paul, S. M.
JO  - Brain Research Bulletin
JF  - Brain Research Bulletin
Y1  - 1992///
VL  - 28
IS  - 2
SP  - 201
EP  - 207
SN  - 0361-9230
AD  - Angel, I.: Clinical Neuroscience Branch, National Institute of Mental Health, NIH, Bethesda, MD 20985, USA.
N1  - Accession Number: 19941408575.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 50-99-7.  Subject Subsets: Human Nutrition; Animal Nutrition
N2  - The acute effects of 2-deoxy-D-glucose (2-DG)-induced glucoprivic feeding on the anorectic drug recognition site and Na+K+-ATPase in the brain were examined in adult male Sprague Dawley rats and in lean and genetically obese mice. The hyperglycaemia and the induction of feeding caused by the administration of 2-DG to satiated rats and lean mice were associated with significant increases in Na+K+-ATPase activity, and in [³H]ouabain binding and [³H]mazindol binding to the anorectic drug recognition site in hypothalamic membranes. Basal and 2-DG-stimulated values of blood glucose were correlated to the values of hypothalamic [³H]ouabain (r = 0.91, P&lt;0.01) and [³H]mazindol (r = 0.87, P&lt;0.01) binding. A correlation (r = 0.74, P&lt;0.05) was also observed between [³H]mazindol binding and [³H]ouabain supporting the hypothesis that these hypothalamic binding sites are functionally coupled in their response to circulating glucose. Following the intracerebroventricular (ICV) administration of the diabetogenic drug alloxan, 2-DG did not stimulate feeding or increase [³H]mazindol and [³H]ouabain binding sites in the hypothalamic paraventricular area. Since 2-DG still caused hyperglycaemia in alloxan-treated rats, alloxan-induced inactivation of glucoreceptor mechanisms led to an uncoupling of the anorectic drug recognition site from a hypothalamic glucostat. In genetically obese mice (ob/ob), 2-DG also could not induce feeding or increase hypothalamic [³H]ouabain or [³H]mazindol binding, despite a significant hyperglycaemic response. In contrast, 2-DG did increase feeding and the binding of [³H]ouabain and [³H]mazindol to the hypothalamus of lean littermates. The dissociation of the anorectic drug recognition site from blood glucose responses to 2-DG suggests that the glucoprivic feeding response in obese mice is impaired. It is concluded that the [³H]mazindol recognition site and the neuronal Na+K+-ATPase labelled by [³H]ouabain binding constitutes a glucoreceptive system which in response to changes in circulating glucose values modulates feeding. Since the coupling of this anorectic drug recognition site to brain glucostats is defective in genetically obese mice, this system may have an important role in pathological hyperphagia and the development of obesity.
KW  - anorexia
KW  - anorexiants
KW  - appetite
KW  - blood sugar
KW  - food intake
KW  - glucose
KW  - hypothalamus
KW  - obesity
KW  - receptors
KW  - mice
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anorectics
KW  - appetite depressants
KW  - appetite suppressors
KW  - blood glucose
KW  - dextrose
KW  - fatness
KW  - glucose in blood
KW  - inappetence
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408575&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Argas (Argas) monolakensis, new species (Acari: Ixodoidea: Argasidae), a parasite of California gulls on islands in Mono Lake, California: description, biology, and life cycle.
AU  - Schwan, T. G.
AU  - Corwin, M. D.
AU  - Brown, S. J.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1992///
VL  - 29
IS  - 1
SP  - 78
EP  - 97
SN  - 0022-2585
AD  - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930513993.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Argas monolakensis sp. nov. is described from adults, nymphs and larvae collected from under and around nests of California gulls (Larus californicus) on islands in Mono Lake, Mono County, California, USA, and from specimens reared in the laboratory. This species is closely related to A. cooleyi, a parasite of cliff swallows (Hirundo pyrrhonota), but is easily distinguished by hypostome dentition and roof of Haller's organ in all stages and chaetotaxy of the larvae. This tick was successfully reared and maintained in the laboratory by feeding them on domestic chickens. Larvae require 5-8 days to feed, whereas all postlarval stages feed rapidly within 9-62 min. At Mono Lake, ticks are above ground and seek hosts only at night. The number of nymphal stages varies from 2 to 5 depending on the developmental temperature and sex of the tick. Ticks overwinter at Mono Lake as 2nd- to 5th-stage nymphs and adults. Ovarian diapause is common with preoviposition periods in extreme cases lasting up to 20 months. This tick will readily feed on humans and has the potential to transmit Mono Lake virus (Orbivirus), which has been isolated from an estimated 2-8% of ticks on various islands.
KW  - Arboviruses
KW  - Biology
KW  - Development
KW  - Diapause
KW  - Disease vectors
KW  - Ecology
KW  - Ectoparasites
KW  - Hosts
KW  - new species
KW  - poultry
KW  - taxonomy
KW  - wild animals
KW  - Wild birds
KW  - California
KW  - North America
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Argasidae
KW  - Birds
KW  - fowls
KW  - Laridae
KW  - Larus californicus
KW  - Man
KW  - Orbivirus
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Metastigmata
KW  - Acari
KW  - vertebrates
KW  - Chordata
KW  - Gallus gallus
KW  - Gallus
KW  - Phasianidae
KW  - Galliformes
KW  - birds
KW  - Charadriiformes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Argas
KW  - Argasidae
KW  - Larus
KW  - Laridae
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Argas monolakensis
KW  - arthropod-borne viruses
KW  - chickens
KW  - domesticated birds
KW  - Mono Lake virus
KW  - systematics
KW  - United States of America
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Animal Behaviour (LL300) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930513993&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of heat shock on the survival of transgenic Anopheles gambiae (Diptera: Culicidae) under antibiotic selection.
AU  - Sakai, R. K.
AU  - Miller, L. H.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1992///
VL  - 29
IS  - 2
SP  - 374
EP  - 375
SN  - 0022-2585
AD  - Sakai, R. K.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930514207.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Registry Number: 1404-04-2.  Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - A gene for neomycin resistance linked to a Drosophila hsp 70 heat shock promoter was introduced into the germ line of A. gambiae. Effects of heat shock at 37 and 41°C on the subsequent survival of the transgenic mosquito subjected to selection by the antibiotic G418 were studied. Heat shock did not enhance the survival of untransformed mosquitoes but greatly increased the survival of the transgenic mosquitoes. Survival after heat shock at 41°C was greater than after heat shock at 37°C.
KW  - Antibiotics
KW  - biotechnology
KW  - drug resistance
KW  - gene expression
KW  - genetic engineering
KW  - Heat shock
KW  - Heat shock proteins
KW  - Neomycin
KW  - resistance
KW  - Transformation
KW  - transgenics
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - genetic manipulation
KW  - mosquitoes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930514207&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Xenopsylla bantorum is an East African subspecies of X. cheopis (Siphonaptera: Pulicidae).
AU  - Schwan, T. G.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1992///
VL  - 29
IS  - 6
SP  - 927
EP  - 933
SN  - 0022-2585
AD  - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930513311.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The geographic distribution, host associations, and male genital morphology of X. bantorum were examined and compared with the Nilotic and Oriental "strains" of X. cheopis. The more acute shape of the 9th sternite separates X. bantorum from all types of X. cheopis; however, the length of the first process of the male's clasper and the number of setae on this process are significantly different among all 3 groups; the Nilotic strain of X. cheopis is intermediate to the others. Specimens collected from both wild and commensal rodents in Nakuru, Kenya, were all X. bantorum, suggesting that X. cheopis present early in the century that resulted from introductions on Rattus rattus had been absorbed by the native X. bantorum population. These factors and a review of opinions by others concerning the status of X. bantorum demonstrate that this flea is not specifically distinct from X. cheopis. The trinomial X. cheopis bantorum is erected. Furthermore, the Nilotic and Oriental "strains" of X. cheopis are distinguishable morphologically solely by the length of the male's first process.
KW  - Ectoparasites
KW  - Geographical distribution
KW  - Hosts
KW  - Morphotaxonomy
KW  - NEW RANK
KW  - nomenclature
KW  - Small mammals
KW  - taxonomy
KW  - Wild animals
KW  - Africa
KW  - East Africa
KW  - Ethiopia
KW  - Kenya
KW  - Arvicanthis niloticus
KW  - Mastomys natalensis
KW  - Muridae
KW  - Pulicidae
KW  - Rattus rattus
KW  - Rodents
KW  - Siphonaptera
KW  - Xenopsylla bantorum
KW  - Xenopsylla cheopis
KW  - Arvicanthis
KW  - Murinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Siphonaptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - Rattus
KW  - Xenopsylla
KW  - Pulicidae
KW  - Xenopsylla cheopis
KW  - Africa South of Sahara
KW  - Africa
KW  - ACP Countries
KW  - East Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - Anglophone Africa
KW  - Commonwealth of Nations
KW  - Mastomys
KW  - Abyssinia
KW  - black rat
KW  - new status
KW  - Oriental rat flea
KW  - PRAOMYS NATALENSIS
KW  - ship rat
KW  - subspecies
KW  - systematics
KW  - Xenopsylla cheopis bantorum
KW  - Biological Resources (Animal) (PP710) 
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930513311&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Health statistics on older persons.
AU  - Havlik, R. J.
A2  - Munro, H. N.
A2  - Schlierf, G.
JO  - Nestlé Nutrition Workshop Series
JF  - Nestlé Nutrition Workshop Series
Y1  - 1992///
VL  - 29
SP  - 7
EP  - 16
CY  - New York; USA
PB  - Raven Press
SN  - 0742-2806
SN  - 0881678740
AD  - Havlik, R. J.: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19921448348.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
KW  - health
KW  - Old age
KW  - statistics
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448348&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selection of ura5 and ura3 mutants for the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium.
AU  - Kwon-Chung, K. J.
AU  - Varma, A.
AU  - Edman, J. C.
AU  - Bennett, J. E.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1992///
VL  - 30
IS  - 1
SP  - 61
EP  - 69
SN  - 0268-1218
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211445.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Spontaneous mutants requiring uracil were isolated from both varieties of C. neoformans by plating on 5-fluoroorotic acid (5-FOA) medium. Of the 36 strs. tested (18 var. neoformans and 18 var. gattii), 24 (12 of each variety) generated 5-FOA-resistant cells requiring uracil for growth. Six of the 12 C. neoformans var. gattii strs. produced ura3 cells while the remaining 6 strs. produced ura5 cells. None of the 12 strs. produced both ura3 cells and ura5 cells. All 12 isolates of var. neoformans, however, produced ura5 cells and 1 produced ura3 as well as ura5 cells. A genetic lesion in the URA5 gene of an isolate of C. neoformans var. gattii was confirmed by complement with the cognate URA5 gene of C. neoformans var. neoformans. The ura3 isolates were tentatively identified by their ability to grow on a medium containing uridine but not on a medium with orotic acid or orotidine. Enzymatic assays for orotidine-5′-phosphate decarboxylase activity confirmed the isolates to be ura3 mutants. Hybridization analysis of total DNA, digested with EcoRI or StuI and probed with pURA5g2, revealed the presence of only one copy of URA5 in the strains of either variety, regardless of the prevalence of ura5 mutants. Extensive polymorphism was observed in the restriction patterns of the fragments containing the URA5 locus. It is concluded that the prevalence of spontaneously arising ura3 mutants among the isolates of C. neoformans var. gattii, but not among the isolates of C. neoformans var. neoformans, is one more biological difference that distinguishes the 2 varieties.
KW  - genetics
KW  - mutants
KW  - Cryptococcus gattii
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus neoformans
KW  - Cryptococcus neoformans var. gattii
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211445&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of Leptospira spp., Leptonema illini, and Rickettsia rickettsii for the 39-kilodalton antigen (P39) of Borrelia burgdorferi.
AU  - Schwan, T. G.
AU  - Schrumpf, M. E.
AU  - Gage, K. L.
AU  - Gilmore, R. D., Jr.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1992///
VL  - 30
IS  - 3
SP  - 735
EP  - 738
SN  - 0095-1137
AD  - Schwan, T. G.: Arthropod-Borne Disease Section, Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515890.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Five serovars of Leptospira interrogans, L. biflexa, Leptonema illini and R. rickettsii were examined and found not to contain the 39-kDa antigen (P39) of B. burgdorferi. The specificity of this antigen and its reactivity with human Lyme disease sera should exclude the possibility of false-positive serum samples from patients having had either leptospirosis or Rocky Mountain spotted fever, as well as tick-borne relapsing fever and syphilis, as reported previously [see W.J. Simpson et al. (1990) Journal of Clinical Microbiology, 28: 1329-1337].
KW  - antigens
KW  - Diagnosis
KW  - Borrelia burgdorferi
KW  - Leptonema illini
KW  - Leptospira
KW  - Man
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Leptospiraceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Leptonema (Bacteria)
KW  - antigenicity
KW  - bacterium
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Identification of the tick-borne relapsing fever spirochete Borrelia hermsii by using a species-specific monoclonal antibody.
AU  - Schwan, T. G.
AU  - Gage, K. L.
AU  - Karstens, R. H.
AU  - Schrumpf, M. E.
AU  - Hayes, S. F.
AU  - Barbour, A. G.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1992///
VL  - 30
IS  - 4
SP  - 790
EP  - 795
SN  - 0095-1137
AD  - Schwan, T. G.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515850.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia hermsii causes a relapsing fever in humans and is one of several species of tick-borne spirochaetes known to occur in the western USA. Spirochaetes observed in the peripheral blood of patients acutely ill have been presumptively identified in the past by the geographic location of exposure and the probable species of tick vector. A monoclonal antibody (H9826) is described that bound to the flagellar protein of B. hermsii but not to those of any of the other species tested, which included B. parkeri, B. turicatae, B. coriaceae, B. anserina, B. burgdorferi and Leptospira interrogans serovar ballum. This antibody bound efficiently to B. hermsii in an indirect immunofluorescence assay and was used to rapidly detect and identify this spirochaete in the peripheral blood of experimentally infected mice and in the central ganglia of Ornithodoros hermsi ticks.
KW  - Antigens
KW  - detection
KW  - Diagnosis
KW  - Diagnostic techniques
KW  - Disease vectors
KW  - Flagella
KW  - Human diseases
KW  - Laboratory animals
KW  - monoclonal antibodies
KW  - Proteins
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Argasidae
KW  - Borrelia hermsii
KW  - Man
KW  - Mice
KW  - Ornithodoros hermsi
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Metastigmata
KW  - Acari
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Muridae
KW  - rodents
KW  - Ornithodoros
KW  - Argasidae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - bacterium
KW  - immunogens
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of polymerase chain reaction primer sets for diagnosis of Lyme disease and for species-specific identification of Lyme disease isolates by 16S rRNA signature nucleotide analysis.
AU  - Marconi, R. T.
AU  - Garon, C. F.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1992///
VL  - 30
IS  - 11
SP  - 2830
EP  - 2834
SN  - 0095-1137
AD  - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, Department of Health and Human Services, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930518654.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 63231-63-0.  Subject Subsets: Medical & Veterinary Entomology
N2  - Partial 16S rRNA sequences from 23 Lyme disease spirochaete isolates were determined and compared, and aligned with 8 sequences previously presented. The 16S rRNA signature nucleotide compositions were defined for each isolate and compared with the genomic species signature nucleotide sets previously established. To identify positions truly indicative of species classification which could serve as targets for polymerase chain reaction (PCR) species-specific identification primers, 16S rRNA-based phylogenetic analyses were conducted. On the basis of the identified signature nucleotides, PCR primer sets were designed which amplified all spirochaete species associated with Lyme disease and differentiated between these species. The primer sets were tested on 38 Borrelia isolates associated with Lyme disease and were found to be sensitive and specific. All Lyme disease isolates tested were amplification positive. These primers allowed for the rapid species identification of Lyme disease isolates.
KW  - Diagnosis
KW  - Diagnostic techniques
KW  - identification
KW  - Lyme disease
KW  - Nucleotide sequences
KW  - polymerase chain reaction
KW  - RNA
KW  - France
KW  - Germany
KW  - Japan
KW  - Russia
KW  - Sweden
KW  - Switzerland
KW  - USA
KW  - Borrelia burgdorferi
KW  - Borrelia garinii
KW  - Man
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - APEC countries
KW  - East Asia
KW  - Asia
KW  - Scandinavia
KW  - Northern Europe
KW  - EFTA
KW  - North America
KW  - America
KW  - bacterium
KW  - DNA sequences
KW  - lyme borreliosis
KW  - PCR
KW  - ribonucleic acid
KW  - Russian Federation
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - DNA probe for strain typing of Cryptococcus neoformans.
AU  - Varma, A.
AU  - Kwon-Chung, K. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1992///
VL  - 30
IS  - 11
SP  - 2960
EP  - 2967
SN  - 0095-1137
AD  - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921213188.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A 7-kb linear plasmid, harboured by a URA5 transformant, hybridized to all the chromosomes of C. neoformans separated by contour-clamped homogeneous electric field electrophoresis. Its linear maintenance was determined to have been facilitated by the presence of telomere-like sequences at its free ends. Hybridization of this plasmid to AccI-digested genomic DNAs of 26 C. neoformans strains generated 21 unique DNA fingerprints. The DNA fingerprints of isolates within the same serotype were more similar to one another than to those from different serotypes. An acapsular clinical isolate, strain 602, widely used in immunological studies and previously thought to be in serotype D, showed DNA fingerprints typical of serotype A isolates. Isogenic strains of C. neoformans exhibited DNA fingerprints that were identical to one another. The DNA fingerprints were stable and reproducible in spite of repeated transfers in the laboratory on either complex (1% yeast extract, 2% Bacto Peptone, 2% glucose) or minimal (yeast nitrogen base) medium. The DNA fingerprints of isolates recovered from primary blood and cerebrospinal fluid cultures of patients for whom AIDS had been diagnosed showed that the original infection in each of these patients contained a homogeneous population of C. neoformans. The DNA fingerprints of isolates recovered from different tissues of infected mice and from patients undergoing different drug therapy regimens were also found to be very stable.
KW  - DNA fingerprinting
KW  - genetics
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aspergillus quadrilineatus, a new causative agent of fungal sinusitis.
AU  - Polacheck, I.
AU  - Nagler, A.
AU  - Okon, E.
AU  - Drakos, P.
AU  - Plaskowitz, J.
AU  - Kwon-Chung, K. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1992///
VL  - 30
IS  - 12
SP  - 3290
EP  - 3293
SN  - 0095-1137
AD  - Polacheck, I.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921213463.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case of A. quadrilineatus pansinusitis is reported in a 28-yr-old woman in Israel with acute non-lymphoblastic leukaemia, who had undergone allogeneic bone marrow transplantation. A. quadrilineatus was cultured from biopsy specimens of the maxillary sinus and tissue sections with fungal stains showed a necrotic area containing dichotomously branching septate hyphae, morphologically consistent with Aspergillus spp. The patient was successfully treated with a combination of surgical debridement, granulocyte transfusions and intravenous administration of amphotericin B-cholesterol sulfate colloidal dispersion (total dose 6.5 g).
KW  - hosts
KW  - infections
KW  - sinuses
KW  - Israel
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - Developed Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - West Asia
KW  - Asia
KW  - Aspergillus quadrilineatus
KW  - fungus
KW  - Hyphomycetes
KW  - mitosporic fungi
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunomodulation and antifungal therapy of experimental invasive candidosis, histoplasmosis and aspergillosis: recent advances and concepts.
AU  - Walsh, T. J.
AU  - Cutsem, J. van
AU  - Polak, A. M.
AU  - Graybill, J. R.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1992///
VL  - 30
IS  - Suppl. 1
SP  - 225
EP  - 240
SN  - 0268-1218
AD  - Walsh, T. J.: Section of Infectious Diseases, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201448.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 53 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Concepts of pathogenesis and immunomodulation in experimental infections caused by Candida spp., Aspergillus spp. and Histoplasma capsulatum and treatment of these infections with single antifungal agents or combinations are reviewed.
KW  - antifungal agents
KW  - aspergillosis
KW  - candidosis
KW  - drug therapy
KW  - experimental infections
KW  - histoplasmosis
KW  - immunology
KW  - immunotherapy
KW  - pathogenesis
KW  - therapy
KW  - Aspergillus
KW  - Candida
KW  - Histoplasma capsulatum
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Histoplasma
KW  - Ajellomyces capsulatus
KW  - candidiasis
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - XI Congress of the International Society for Human and Animal Mycology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Five-year plan for nutrition research and training: executive summary.
JO  - Pediatric Research
JF  - Pediatric Research
Y1  - 1992///
VL  - 32
IS  - 1
SP  - 1
EP  - 9
SN  - 0031-3998
AD  - Office of Research Reporting, National Institute of Child Health and Human Development, Building 31, Room 2A32, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931460258.  Publication Type: Journal Article.  Corporate Author: USA, National Institute of Child Health and Human Development Language: English.  Subject Subsets: Human Nutrition
N2  - A summary of the recommendations of a meeting of the Endocrinology, Nutrition and Growth branch of the National Institute of Child Health and Human Development is presented.
KW  - Children
KW  - guidelines
KW  - Infants
KW  - nutrition research
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - recommendations
KW  - United States of America
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease.
AU  - Kárpáti, S.
AU  - Meurer, M.
AU  - Stolz, W.
AU  - Bürgin-Wolff, A.
AU  - Braun-Falco, O.
AU  - Krieg, T.
JO  - Gut
JF  - Gut
Y1  - 1992///
VL  - 33
IS  - 2
SP  - 191
EP  - 193
SN  - 0017-5749
AD  - Kárpáti, S.: Building 10, R12N242, National Institutes of Health, Dermatology Branch of the National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931458184.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Human Nutrition
N2  - The ultrastructural binding sites of endomysium antibodies, specific serological markers of gluten sensitive enteropathy, were investigated in the rabbit oesophagus using the immunogold technique. Endomysium antibodies from sera of patients with dermatitis herpetiformis and with coeliac disease bound in an identical manner in a non-fibrillar material closely associated with fine collagenous-reticulin fibrils and also with similar fibrils connecting smooth muscle cells and elastic tissue in the endomysial connective tissue. These observations suggest that IgA antibodies in sera from patients with dermatitis herpetiformis and coeliac disease recognise a common antigen in an amorphous component associated with the reticular connective tissue of oesophageal lamina muscularis mucosae and thus confirm the probable identity of IgA class endomysium and jejunal antibodies.
KW  - antibodies
KW  - binding sites
KW  - Coeliac syndrome
KW  - Dermatitis herpetiformis
KW  - IgA
KW  - in vitro
KW  - Jejunum
KW  - Oesophagus
KW  - small intestine
KW  - Man
KW  - Rabbits
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - binding site
KW  - celiac disease
KW  - celiac syndrome
KW  - coeliac disease
KW  - esophagus
KW  - gluten allergy
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transport of n-3 fatty acids from the intestine to the retina in rats.
AU  - Li, J.
AU  - Wetzel, M. G.
AU  - O'Brien, P. J.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1992///
VL  - 33
IS  - 4
SP  - 539
EP  - 548
SN  - 0022-2275
AD  - Li, J.: Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, MD, USA.
N1  - Accession Number: 19941408547.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 25167-62-8, 463-40-1.  Subject Subsets: Human Nutrition; Animal Nutrition
N2  - This study was undertaken to examine the mode of transport of docosahexaenoic acid C22:6(n-3) and linolenic acid C18:3(n-3). Male weanling Sprague-Dawley rats received a mixture of maize oil and [14C]18:3(n-3) or [14C]22:6(n-3) by gavage. At periods of 1 to 4 days after the injection, 4 rats per time point were killed and samples of blood were taken via heart puncture and the livers and retinas were collected. Blood lipoproteins and plasma proteins were separated by ultracentrifugation and analysed by HPLC. Lipids were extracted and saponified and the fatty acids were converted to phenacyl esters for separation of individual fatty acids. After 1 and 2 h, radioactivity from C18:3(n-3) and C22:6(n-3) was observed primarily in the chylomicron/VLDL fraction. By 4 h, radioactivity in the lipoprotein fraction was greatly decreased, with a small amount of radioactivity associated with albumin in the soluble protein fraction. After 24 h, the total amount of radioactivity associated with lipoprotein was further reduced, with more than half of the remaining label occurring in association with albumin and another unidentified protein. In the liver, C22:6(n-3) was concentrated in triacylglycerols (40.7%) and phospholipids (51.1%), with a maximum specific activity at 4 h. In the rod outer segments (ROS), the specific activity of [14C]22:6(n-3) increased to a maximum at 24 h and maintained a high value even at 4 days. These data suggest that after injection, C18:3(n-3) and C22:6(n-3) are esterified to triglyceride and phospholipid by the intestinal absorptive cells and transported in chylomicrons to the liver. After conversion of C18:3(n-3) to C22:6(n-3) in the liver, the retina accumulates C22:6(n-3) which may be transported from the liver via albumin and another unidentified protein, and is retained by the rod outer segments.
KW  - chylomicron lipids
KW  - docosahexaenoic acid
KW  - fatty acids
KW  - intestines
KW  - linolenic acid
KW  - metabolism
KW  - retina
KW  - serum albumin
KW  - transport
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chylomicrons
KW  - transportation
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis carinii induction of tumor necrosis factor-α by alveolar macrophages: modulation by pentamidine isethionate.
AU  - Corsini, E.
AU  - Dykstra, C.
AU  - Craig, W. A.
AU  - Tidwell, R. R.
AU  - Rosenthal, G. J.
JO  - Immunology Letters
JF  - Immunology Letters
Y1  - 1992///
VL  - 34
IS  - 3
SP  - 303
EP  - 308
SN  - 0165-2478
AD  - Corsini, E.: Immunotoxicology Section, Division of Toxicology Research and Testing, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19950802517.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 9008-11-1, 100-33-4, 140-64-7, 308079-78-9.  Subject Subsets: Protozoology
N2  - Pneumocystis carinii cysts were found to be capable of inducing tumour necrosis factor-α (TNF) release from alveolar macrophages in rats, in a concentration-dependent manner. Pentamidine isethionate (pentamidine) reduced this TNF production dose-dependently to over 50% at physiologically achievable concentrations (0.01-10.00 µM). Pretreatment of alveolar macrophages with interferon-γ (IFN-γ) synergized with P. carinii to produce increased levels of TNF. Pentamidine treatment antagonized this condition but did not interfere with the phagocytic ability of the macrophages. It is possible that anti-inflammatory properties of inhaled pentamidine can reduce the detrimental effects associated with the overproduction of TNF in the lower lung. Suppression of inflammatory mediators such as TNF, together with a direct effect of pentamidine on P. carinii, may be a critical factor in the efficacy of the drug.
KW  - drug therapy
KW  - immune response
KW  - immunocompromised hosts
KW  - interferon
KW  - laboratory mammals
KW  - opportunistic infections
KW  - parasites
KW  - pentamidine
KW  - tumour necrosis factor
KW  - Muridae
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - rats
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - Muridae
KW  - cachectin
KW  - cachexin
KW  - chemotherapy
KW  - fungus
KW  - immunity reactions
KW  - immunological reactions
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - NIAID [National Institute of Allergy and Infectious Diseases] tropical disease research: priorities and future directions.
AU  - Western, K. A.
JO  - Tropical Medicine (Nagasaki)
JF  - Tropical Medicine (Nagasaki)
Y1  - 1992///
VL  - 34
IS  - 4
SP  - 157
EP  - 163
SN  - 0385-5643
AD  - Western, K. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940801385.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 14 ref. Subject Subsets: Helminthology; Protozoology
KW  - helminths
KW  - parasites
KW  - research
KW  - teaching
KW  - tropical medicine
KW  - Maryland
KW  - North America
KW  - USA
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - instruction
KW  - parasitic worms
KW  - studies
KW  - United States of America
KW  - Research (AA500) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The origin of plagues: a research agenda for the 21st Century.
AU  - Krause, R. M.
JO  - Tropical Medicine (Nagasaki)
JF  - Tropical Medicine (Nagasaki)
Y1  - 1992///
VL  - 34
IS  - 4
SP  - 165
EP  - 170
SN  - 0385-5643
AD  - Krause, R. M.: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19940801386.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 7 ref. Subject Subsets: Protozoology
KW  - control
KW  - human diseases
KW  - parasites
KW  - teaching
KW  - tropical medicine
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - discussed
KW  - instruction
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
AU  - Kashman, Y.
AU  - Gustafson, K. R.
AU  - Fuller, R. W.
AU  - Cardellina, J. H., II
AU  - McMahon, J. B.
AU  - Currens, M. J.
AU  - Buckheit, R. W., Jr.
AU  - Hughes, S. H.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1992///
VL  - 35
IS  - 15
SP  - 2735
EP  - 2743
SN  - 0022-2623
AD  - Kashman, Y.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19940600764.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Horticultural Science; Forestry; Forest Products
N2  - Eight new coumarin compounds were isolated by anti-HIV bioassay-guided fractionation of an extract of fruits and twigs of Calophyllum lanigerum from Sarawak, Malaysia. The chemistry and biological activity of each compound are described. Calanolides A and B were completely protective against HIV-1 replication and cytopathicity, but were inactive against HIV-2. Some of the related compounds also showed evidence of anti-HIV-1 activity. The calanolides were specific HIV-1 reverse transcriptase inhibitors; calanolide A was active against both the AZT-resistant G-9106 strain of HIV-1 and the pyridone-resistant A17 strain.
KW  - broadleaves
KW  - coumarins
KW  - medicinal plants
KW  - medicinal properties
KW  - trees
KW  - woody plants
KW  - Malaysia
KW  - Sarawak
KW  - plants
KW  - eukaryotes
KW  - Calophyllum
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - APEC countries
KW  - ASEAN Countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - Threshold Countries
KW  - Borneo
KW  - Malaysia
KW  - Calophyllum lanigerum
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Non-wood Forest Products (KK540) 
KW  - Non-food/Non-feed Plant Products (SS200) 
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ER  - 

TY  - JOUR
T1  - Low bias in assayed values of lipoprotein antigens-lipoprotein(a) and apolipoprotein A-1 and B-in midday postprandial blood specimens compared with morning fasting specimens.
AU  - Emancipator, K.
JO  - Clinical Chemistry
JF  - Clinical Chemistry
Y1  - 1992///
VL  - 38
IS  - 3
SP  - 431
EP  - 433
SN  - 0009-9147
AD  - Emancipator, K.: Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19931465098.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Subject Subsets: Human Nutrition
N2  - 2-h postprandial specimens had a -14% proportional bias for lipoprotein(a) (Lp(a)), a -0.035 g/litre systematic bias for apolipoprotein (apo) A-1, and a -9% proportional bias for apo B, compared with values in 12-h fasting specimens. Although a physiological haemodilution appears to account for a proportion of these biases, other major factors must be implicated for Lp(a) and apo B. Even after dilutional effects are controlled for, assayed values of Lp(a) were 11-13% lower, and assayed values of apo B were 8-9% lower, in postprandial specimens than in fasting specimens. Therefore, the time of collection of blood sample relative to the last meal can significantly affect assayed values of lipoprotein antigens.
KW  - Analytical methods
KW  - Apolipoproteins
KW  - assays
KW  - blood
KW  - fasting
KW  - food intake
KW  - Lipoproteins
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - Techniques and Methodology (ZZ900) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465098&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stereo views and immunogold labeling of the pellicular microtubules at the inner surface of the plasma membrane of Leishmania as revealed by fracture-flip.
AU  - Hou, W. Y.
AU  - Pimenta, P. F. P.
AU  - Ru-Long, S.
AU  - Silva, P. P. da
JO  - Journal of Histochemistry and Cytochemistry
JF  - Journal of Histochemistry and Cytochemistry
Y1  - 1992///
VL  - 40
IS  - 9
SP  - 1309
EP  - 1318
SN  - 0022-1554
AD  - Hou, W. Y.: Structural Biology Section, Laboratory of Mathematical Biology (W-YH, SR-L,PPS), National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19930802332.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology
N2  - A modification of fracture-flip was used to reveal the nanoanatomy of the inner surface of the plasma membrane in promastigotes of Leishmania major. After freeze-fracture, lightly fixed promastigotes were coated with a stabilizing layer of carbon evaporated from an electron gun, thawed, and washed. Fractured promastigotes attached to the carbon casts by the protoplasmic (i.e., inner) halves of their plasma membranes were treated with Triton X-100, followed by exposure to low concentrations of trypsin and thorough washing. This was followed by picking up and flipping of the replicas, followed by air-drying. The actual inner surfaces of the plasma membrane were then imaged by platinum shadowing. Extended, 3-dimensional, high-resolution views of the inner surface of the plasma membrane showed parallel arrays of microtubules (average spacing 47 nm) closely apposed to the inner surface. Cytochemical labelling confirmed the morphological identification of both subpellicular and flagellar microtubules, as determined by treatment with mouse monoclonal anti-α- or anti-β-tubulin, followed by labelling with goat anti-mouse IgG absorbed to colloidal gold. Removal of the microtubules revealed parallel arrays of particles (average diameter 17 nm). It is hypothesized that these particles represent the cytoplasmic portion of proteins that link the microtubules to the plasma membrane.
KW  - Human diseases
KW  - microtubules
KW  - parasites
KW  - Plasma membranes
KW  - ultrastructure
KW  - Leishmania major
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cell membrane
KW  - plasmalemma
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetically obese rats with (SHR/N-cp) and without diabetes (LA/N-cp) share abnormal islet responses to glucose.
AU  - Timmers, K. I.
AU  - Voyles, N. R.
AU  - Recant, L.
JO  - Metabolism, Clinical and Experimental
JF  - Metabolism, Clinical and Experimental
Y1  - 1992///
VL  - 41
IS  - 10
SP  - 1125
EP  - 1133
SN  - 0026-0495
AD  - Timmers, K. I.: Building 10, Room 5N102, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402232.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 50-99-7.  Subject Subsets: Human Nutrition
N2  - To assess the effect of hyperglycaemia on the function of islets obtained from obese rats, the behaviour of isolated islets from LA/N-corpulent (non-diabetic obese) and SHR/N-corpulent (diabetic obese) male rats was examined and compared. Islets from both genetic models showed a left-shifted glucose dose-response curve for insulin release (concentrations for half-maximal release, 5 to 6 vs. 12 to 13 mmol/litre in LA/N lean littermates and 3 vs. 10 mmol/litre in lean SHR/N). When insulin release was expressed per unit islet volume, the 4- to 5-fold enlarged islets from obese diabetic and obese non-diabetic rats showed decreased insulin secretory response in high (16.5 to 28 mmol/litre) glucose concentrations, although the decrease was more severe in the diabetic rats. Glucose-stimulated insulin release by islets from both models was relatively resistant to inhibition by mannoheptulose 1.2 mmol/litre (e.g., 82±3% inhibition in LA/N lean vs. 16±8% in LA/N obese), although nearly complete inhibition was observed with mannoheptulose 16 mmol/litre (96 vs. 85%, not significant). Islets of obese diabetic rats were also resistant to the calcium-channel blocker, verapamil, suggesting an abnormal pathway of stimulus-secretion coupling for glucose. Glucose oxidation to carbon dioxide was increased in both obese models at all glucose concentrations when expressed per islet. In data express per unit volume, the larger islets from the obese-nondiabetic rats showed a left-shifted dose-response curve with an unchanged maximum rate of glucose oxidation at high (16.5 mmol/litre) glucose concentrations. Reduced immunoreactive glucose transporter protein (Glut-2) was found in nondiabetic- and diabetic-obese islets. The data demonstrate that many of the islet lesions associated with high plasma glucose concentrations also can arise in genetic obesity in the absence of sustained hyperglycaemia.
KW  - diabetes
KW  - glucose
KW  - glucose tolerance
KW  - hyperglycaemia
KW  - in vitro
KW  - insulin secretion
KW  - obesity
KW  - pancreas islets
KW  - responses
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood sugar tolerance
KW  - dextrose
KW  - fatness
KW  - high blood glucose
KW  - hyperglycemia
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP syndrome).
AU  - Higgins, J. J.
AU  - Patterson, M. C.
AU  - Papadopoulos, N. M.
AU  - Brady, R. O.
AU  - Pentchev, P. G.
AU  - Barton, N. W.
JO  - Neurology
JF  - Neurology
Y1  - 1992///
VL  - 42
IS  - 1
SP  - 194
EP  - 198
SN  - 0028-3878
AD  - Higgins, J. J.: Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D03, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931464125.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Clinical and laboratory studies of an 11-year-old girl with prominent orofacial dyskinesia, dystonia and progressive dementia are described. Investigations revealed hypoprebetalipoproteinaemia, acanthocytosis, atypical retinitis pigmentosa and evidence of iron deposition in the pallidal nuclei. Electroneuromyography and skin and sural nerve biopsies were normal. The "eye-of-the-tiger" sign, used to described the pallidal nuclei in Hallervorden-Spatz syndrome, was present on T2-weighted magnetic resonance images. Phase-contrast microscopy of whole blood showed 80-90% acanthocytes whose morphology was confirmed by electron microscopy. High-resolution lipoprotein electrophoresis demonstrated an absence of the pre-beta fraction. This case differs phenotypically from previous reports of Hallervorden-Spatz disease with acanthocytosis by the presence of prominent orofacial dyskinesia and abnormal serum lipoproteins.
KW  - case reports
KW  - Children
KW  - hypolipoproteinaemia
KW  - nervous system diseases
KW  - Retinitis pigmentosa
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hypolipoproteinemia
KW  - neuropathy
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum albumin in older persons: relationship with age and health status.
AU  - Salive, M. E.
AU  - Cornoni-Huntley, J.
AU  - Phillips, C. L.
AU  - Guralnik, J. M.
AU  - Cohen, H. J.
AU  - Ostfeld, A. M.
AU  - Wallace, R. B.
JO  - Journal of Clinical Epidemiology
JF  - Journal of Clinical Epidemiology
Y1  - 1992///
VL  - 45
IS  - 3
SP  - 213
EP  - 221
SN  - 0895-4356
AD  - Salive, M. E.: Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Gateway Building, Suite 3C309, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931468236.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Data was analysed from 4115 persons, 71 years old, who had blood drawn at a home visit in 3 communities, to examine the cross-sectional distribution of serum albumin and correlates of hypoalbuminaemia. Mean albumin was lower among older persons from 41.6 in men 71-74 years old to 38.5 g/litre in men ≥90 years old, and from 41.1 to 38.9 g/litre in women of the same ages, respectively. Hypoalbuminaemia (albumin &lt;35 g/litre) was observed in 3.1% of subjects. Hypoalbuminaemia and lower serum albumin were independently associated with anaemia, recent diagnosis of cancer, 2 or more limitations in activities of daily living, residence in a nursing home, heavy cigarette smoking (&gt;1 pack/day), and older age. A 10-year age increment was associated with 0.8 g/litre lower serum albumin and odds ratio of 1.56 (95% CI 1.14, 2.13) for hypoalbuminaemia after adjusting for demographic factors and health status. Characteristics associated with serum albumin may confound the reported relation between serum albumin and mortality.
KW  - age
KW  - Anaemia
KW  - Carcinoma
KW  - health
KW  - Hypoalbuminaemia
KW  - Old age
KW  - serum albumin
KW  - Tobacco smoking
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anemia
KW  - hypoalbuminemia
KW  - Physiology of Human Nutrition (VV120) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spotted fever rickettsiae in ticks from the northern Sinai Governorate, Egypt.
AU  - Lange, J. V.
AU  - El-Dessouky, A. G.
AU  - Manor, E.
AU  - Merdan, A. I.
AU  - Azad, A. F.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1992///
VL  - 46
IS  - 5
SP  - 546
EP  - 551
SN  - 0002-9637
AD  - Lange, J. V.: Office of Tropical Medicine and International Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building CDB-3C25, 6003 Executive Boulevard, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920510808.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - A field study was initiated in 1988 to investigate whether spotted fever group rickettsiae occur in geographic areas in Egypt that are adjacent to an area in the southern Israeli Negev that has a defined focus of spotted fever disease. Ticks were collected in June-September 1988 and 1989 from dogs, sheep and camels at 4 study sites in the northern Sinai. Tick haemolymph was processed for rickettsial detection by staining with fluorescein isothiocyanate-conjugated antibody to Rickettsia rickettsii. Of the 442 haemolymph samples examined, 15 contained immunofluorescent rickettsiae. 8 Rhipicephalus sanguineus removed from dogs were haemolymph test-positive (HT+); the other HT+ ticks comprised 3 Hyalomma species, H. anatolicum, H. impeltatum and H. dromedarii. Both HT+ and HT- ticks were tested for rickettsial DNA using the polymerase chain reaction (PCR). 8 of 10 HT+ field-collected ticks were PCR positive (PCR+). All laboratory colony R. rickettsii-infected ticks were PCR+. No HT- ticks from field or laboratory isolates were PCR+.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A field study was initiated in 1988 to investigate whether spotted fever group rickettsiae occur in geographic areas in Egypt that are adjacent to an area in the southern Israeli Negev that has a defined focus of spotted fever disease. Ticks were collected from dogs, sheep, and camels at four study sites in the northern Sinai. Tick hemolymph was processed for rickettsial detection by staining with fluorescein isothiocyanate-conjugated antibody to Rickettsia rickettsii. Of the 442 hemolymphs examined, 15 contained immunofluorescent rickettsiae. Eight hemolymph test-positive (HT+) ticks were Rhipicephalus sanguineus removed from dogs; the other HT+ ticks comprised three Hyalomma species, H. anatolicum, H. impeltatum, and H. dromedarii. Both HT+ and HT- ticks were tested for rickettsial DNA using the polymerase chain reaction (PCR). Eight of 10 HT+ field-collected ticks were PCR positive (PCR+). All laboratory colony R. rickettsii-infected ticks were PCR+. No HT- ticks from field or laboratory isolates were PCR+.AS
KW  - Disease vectors
KW  - Polymerase chain reaction
KW  - rickettsial diseases
KW  - Zoonoses
KW  - Africa
KW  - Asia
KW  - Egypt
KW  - Middle East
KW  - North Africa
KW  - Acari
KW  - Arachnida
KW  - Camelus
KW  - Dogs
KW  - Dromedaries
KW  - Goats
KW  - Hyalomma anatolicum
KW  - Hyalomma dromedarii
KW  - Hyalomma impeltatum
KW  - Ixodidae
KW  - Metastigmata
KW  - Rhipicephalus sanguineus
KW  - Rickettsia
KW  - Rickettsia rickettsii
KW  - Rickettsiaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Camelidae
KW  - Tylopoda
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - Camelus
KW  - Capra
KW  - Bovidae
KW  - ruminants
KW  - Hyalomma
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Rhipicephalus
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Rickettsia
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - West Asia
KW  - Asia
KW  - bacterium
KW  - camels
KW  - Camelus dromedarius
KW  - Misr
KW  - Near East
KW  - northern Sinai
KW  - PCR
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Persistence of eggs and hepatic fibrosis after treatment of Schistosoma mansoni-infected mice.
AU  - Cheever, A. W.
AU  - Macedonia, J. G.
AU  - Deb, S.
AU  - Cheever, E. A.
AU  - Mosimann, J. E.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1992///
VL  - 46
IS  - 6
SP  - 752
EP  - 758
SN  - 0002-9637
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19920800904.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 26328-53-0, 55268-74-1, 15489-16-4.  Subject Subsets: Helminthology; Tropical Diseases
N2  - In 1971 it was estimated that S. mansoni eggs in the tissues of mice were destroyed with an approximate half-life of 4 weeks. The present results of 5 experiments using BALB/cAnN and C57B1/6CR mice suggest that egg destruction is not as rapid, and no significant destruction of eggs was detected for up to 26 weeks after treatment with either praziquantel, amoscanate or stibophen. However, in these experiments, a mean of 60% of the eggs in intestinal tissues were found in the faeces at the time of treatment. In previously reported experiments only 15% of gut eggs were passed in the faeces. It is now believed that underestimation of the number of eggs passed in the faeces led to an overestimation of the number of eggs destroyed in the tissues. The liver eggs were analyzed separately because eggs lost from this site are unaffected by eggs passed in the faeces. No significant decrease in liver eggs occurred in the present experiments, but reanalysis of previously published data showed significant egg destruction in the liver in several experiments, although at a much slower rate than previously estimated. However, inspection of the data in the previously published and present experiments does not show a convincing difference in the number of eggs in the liver after treatment. The persistence of egg shells is probably not important in the pathogenesis of disease, but is of concern in calculating worm fecundity. Hepatic collagen levels increased markedly 2 weeks after treatment and subsequently decreased significantly in some, but not all, experiments.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors report that they could detect no significant destruction of Schistosoma mansoni eggs in the tissues of mice for up to 26 weeks after their chemotherapeutic cure 7-8 weeks after infection. This result contrasts with a previous estimate from this group of a half-life for tissue eggs of about 4 weeks in treated mice [see Trop. Dis. Bull., 1972, 69, abst. 56]. The experimental reasons for the different results are explored.Carolyn A. Brown
KW  - Amoscanate
KW  - drug therapy
KW  - helminths
KW  - Human diseases
KW  - Laboratory animals
KW  - Liver
KW  - Ova
KW  - parasites
KW  - Praziquantel
KW  - schistosomiasis
KW  - Stibophen
KW  - treatment
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - chemotherapy
KW  - egg persistence
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma concentrations of glucose, insulin, and percent glycosylated hemoglobin are unaltered by food restriction in Rhesus and Squirrel monkeys.
AU  - Cutler, R. G.
AU  - Davis, B. J.
AU  - Ingram, D. K.
AU  - Roth, G. S.
JO  - Journal of Gerontology
JF  - Journal of Gerontology
Y1  - 1992///
VL  - 47
IS  - 1
SP  - B9
EP  - B12
SN  - 0022-1422
AD  - Cutler, R. G.: G. S. Roth, Gerontology Research Center, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
N1  - Accession Number: 19931465125.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Plasma concentrations of glucose and percentage of glycosylated haemoglobin have been reported to be reduced in food-restricted rats when compared with freely fed controls [Masoro et al., Journal of Gerontology (1989) 44, B20-B22]. In a similar experiment in primates, plasma insulin was also estimated. Rhesus and squirrel monkeys were fed freely 30% less than weight-matched controls for up to 36 months. No significant age or diet effects on plasma concentration of glucose, insulin or percentage glycosylated haemoglobin were observed, except that glucose values and the percentage of glycosylated haemoglobin could be established within any group of monkeys. The results suggest possible differences in glucose-related metabolism in freely fed and food-restricted primates compared with observations made in rats.
KW  - blood
KW  - Blood sugar
KW  - food restriction
KW  - Haemoglobin
KW  - Insulin
KW  - Macaca mulatta
KW  - monkeys
KW  - Saimiri
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Cebidae
KW  - blood glucose
KW  - glucose in blood
KW  - glycosylation
KW  - hemoglobin
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea.
AU  - Gustafson, K. R.
AU  - Blunt, J. W.
AU  - Munro, M. H. G.
AU  - Fuller, R. W.
AU  - McKee, T. C.
AU  - Cardellina, J. H., II
AU  - McMahon, J. B.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
JO  - Tetrahedron
JF  - Tetrahedron
Y1  - 1992///
VL  - 48
IS  - 46
SP  - 10093
EP  - 10102
SN  - 0040-4020
AD  - Gustafson, K. R.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick Cancer Research & Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19940308232.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Forestry
N2  - Seven new polyisoprenylated benzophenone derivatives and/or related benzophenone derivatives were isolated from members of the Guttiferae family: guttiferones A-D from the roots of Symphonia globulifera, and guttiferone E and isoxanthochymol from the leaves of Garcinia ovalifolia (samples of both species collected from the Central African Republic, in March 1988); guttiferone A from the fruits of G. livingstonei (collected from Tanzania, in Dec. 1988); and guttiferone E and xanthochymol from the leaves of Clusia rosea (collected from the Dominican Republic). The chemical structures of these compounds were elucidated from spectral analyses. All compounds except for isoxanthochymol inhibited the cytopathic effects of in vitro HIV infection in human lymphoblastoid CEM-SS cells (EC50 values of 1-10 μg/ml). Cytotoxicity occurred at concentrations above 50 μg/ml. There was no indication of a corresponding decrease in indices of viral replication.
KW  - antiviral plants
KW  - antiviral properties
KW  - chemical composition
KW  - foliage
KW  - forest trees
KW  - fruits
KW  - human immunodeficiency viruses
KW  - ketones
KW  - leaves
KW  - medicinal plants
KW  - plant composition
KW  - roots
KW  - sesquiterpenoids
KW  - spectral analysis
KW  - trees
KW  - woody plants
KW  - Central African Republic
KW  - Dominican Republic
KW  - Tanzania
KW  - Clusiaceae
KW  - Garcinia
KW  - plants
KW  - Symphonia globulifera
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Clusiaceae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Symphonia
KW  - Clusia
KW  - Garcinia
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - Hispaniola
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Latin America
KW  - Threshold Countries
KW  - Anglophone Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - SADC Countries
KW  - anti-viral properties
KW  - benzophenones
KW  - chemical constituents of plants
KW  - chemical structures
KW  - Clusia rosea
KW  - drug plants
KW  - Garcinia livingstonei
KW  - Garcinia ovalifolia
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Tanganyika
KW  - Plant Composition (FF040) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-wood Forest Products (KK540) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Silviculture and Forest Management (KK110) 
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Two types of sequence polymorphism in the circumsporozoite gene of Plasmodium falciparum.
AU  - McCutchan, T. F.
AU  - Lal, A. A.
AU  - Rosario, V. do
AU  - Waters, A. P.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1992///
VL  - 50
IS  - 1
SP  - 37
EP  - 45
SN  - 0166-6851
AD  - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920877162.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Protozoology
N2  - Two characteristically different classes or types of gene sequence variation in the circumsporozoite protein from P. falciparum were demonstrated. Some patterns of sequence variation suggest, or are at least consistent with, Mendelian inheritance. The patterns of sequence variation at specific positions, introduced homoplasy (similarity or identity not directly attributable to common ancestry) into the relationship between parasites. The demonstration of extensive homoplasy in a malaria gene raises questions about the validity of familial relationships established among parasites with polymorphic markers. It is suggested that homoplasy at particular positions could mark a site of biological pressure on the parasite where interaction of the site with factors in the environment affects the success of the parasite population. The circumsporozoite protein in malarial vaccine constructs is discussed. An approach to structural analysis that demonstrates and quantitates the degree of homoplasy in particular positions of a protein is described.
KW  - circumsporozoite protein
KW  - Genes
KW  - Genetics
KW  - Human diseases
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a Giardia lamblia variant-specific surface protein (VSP) gene from isolate GS/M and estimation of the VSP gene repertoire size.
AU  - Nash, T. E.
AU  - Mowatt, M. R.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1992///
VL  - 51
IS  - 2
SP  - 219
EP  - 227
SN  - 0166-6851
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878382.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 52-90-4.  Subject Subsets: Protozoology; Tropical Diseases
N2  - Giardia lamblia undergoes surface antigenic variation. The variant-specific surface proteins (VSPs) of isolate WB are cysteine-rich, can vary dramatically in size, contain Cys-X-X-Cys motifs, and are differentially expressed. GS/M(H7) is a Giardia clone from a different isolate which expresses a VSP epitope not found in WB. The VSP gene encoding this epitope was selected by differential hybridization using radiolabelled cDNA from H7 and variant sibling trophozoite lines from the same isolate that express other VSPs. The VSPH7 gene probe detects an 1800 nucleotide transcript abundant in H7 but undetectable in variant siblings. Primer extension directly from RNA was used to complete the gene sequence which predicted a protein with a MW of 56 832. The protein showed many of the characteristics of 2 previously sequenced WB VSPs including many Cys-X-X-Cys tetrapeptides and a conserved carboxy-terminal region. Genomic Southern analysis indicated the presence of 2 distinct VSPH7 genes in H7. An oligonucleotide from the conserved region was used in combination with one specific for the VSPH7 gene to estimate the VSP repertoire size at between 133 and 151. VSPs, even from isolates expressing unique epitopes, constitute a family of related proteins.
KW  - Antigenic variation
KW  - antigens
KW  - Cysteine
KW  - Genes
KW  - Human diseases
KW  - Nucleotide sequences
KW  - parasites
KW  - Proteins
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - DNA sequences
KW  - GIARDIA LAMBLIA
KW  - immunogens
KW  - variant-specific surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An RFLP map of the Plasmodium falciparum genome, recombination rates and favored linkage groups in a genetic cross.
AU  - Walker-Jonah, A.
AU  - Dolan, S. A.
AU  - Gwadz, R. W.
AU  - Panton, L. J.
AU  - Wellems, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1992///
VL  - 51
IS  - 2
SP  - 313
EP  - 320
SN  - 0166-6851
AD  - Walker-Jonah, A.: T.E. Wellems, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878391.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A genetic linkage map of the P. falciparum genome is reported, using the inheritance patterns of nearly 90 restriction fragment length polymorphism markers in a genetic cross. Markers were assigned to polymorphic loci on all 14 nuclear chromosomes. Genetic recombination between parental markers was detected in each of the progeny, indicating that progeny from cross-fertilization events were favoured over progeny from self-fertilization of either parent alone. Inheritance patterns among the markers suggested that certain parental linkage groups on chromosomes 2, 3, 12 and 13 were favoured in the cross. Recombination frequencies on 5 chromosomes indicated an approximate map unit size of 15-30 kb per centiMorgan for P. falciparum.
KW  - Gene mapping
KW  - genomes
KW  - Human diseases
KW  - Molecular genetics
KW  - parasites
KW  - restriction fragment length polymorphism
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - genetic linkage map
KW  - RFLP
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aflatoxin-transformed C3H/10T1/2 cells overexpress protein kinase C and have an altered response to phorbol ester treatments.
AU  - Dunn, J. A.
AU  - Faletto, M. B.
AU  - Kasper, S. J.
AU  - Gurtoo, H. L.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
IS  - 4
SP  - 990
EP  - 996
SN  - 0008-5472
AD  - Dunn, J. A.: Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19921211328.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The aflatoxin B1-transformed C3H/10T1/2 (10T1/2) cell line 7SA has disordered growth in culture and is tumorigenic in syngeneic mice. Chronic exposure (14 d) of 10T1/2 and 7SA cells to phorbol 12,13-dibutyrate (PDBu) increased the saturation density of 10T1/2 cells but dramatically slowed the entry of 7SA cells into the log phase of growth without affecting their final saturation density, Similar PDBu treatment of low-density cultures dramatically decreased the size of 7SA colonies. Both cell lines bound [³H]PDBu in a specific and saturable manner. Analysis of this binding yielded linear Scatchard plots for both cell lines with distinctly different Kd values (10.7 nM for 10T1/2 vs. 54.5 nM for 7SA). The total amount of [³H]PDBu bound was 2-fold greater in the 7SA cells vs. the 10T1/2 cell line. Both cell lines released arachidonic acid following a 2-h exposure to PDBu; however, the magnitude of the response of the 7SA cells was only 50% that of the 10T1/2 cells. Western blot analysis of protein kinase C (PKC) using specific anti-PKC antibodies revealed a greater total amount of PKCα in the 7SA cells relative to an equal number of 10T1/2 cells. No immunoreactive PKCα was found in either cell line 16 h after exposure to 600 nM PDBu; however, PKCα returned to control levels in both cell lines 24 h after removal of the phorbol ester. It is suggested that an overexpression of PKCα may play a role in the altered biological properties of aflatoxin-transformed 10T1/2 cells.
KW  - Aflatoxins
KW  - carcinogenesis
KW  - Mycotoxins
KW  - toxicity
KW  - fungal toxins
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates.
AU  - Fujimoto, Y.
AU  - Hampton, L. L.
AU  - Luo, L.
AU  - Wirth, P. J.
AU  - Thorgeirsson, S. S.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
IS  - 4
SP  - 1044
EP  - 1046
SN  - 0008-5472
AD  - Fujimoto, Y.: S. S. Thorgeirsson, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211329.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Nine tumours induced by aflatoxin B1 in non-human primates (Macaca mulatta and M. fascicularis) were analysed for mutations in the p53 gene. These included 4 hepatocellular carcinomas, 2 cholangiocarcinomas, a spindle cell carcinoma of the bile duct, a haemangio-endothelial sarcoma of the liver and an osteogenic sarcoma of the tibia. None of the tumours showed changes at the third position of codon 249 by cleavage analysis of the HaeIII enzyme site at codon 249. A point mutation was identified in one hepatocellular carcinoma at the second position of codon 175 (G to T transversion) by sequencing analysis of the 4 conserved domains (II to V) in the p53 gene. It is concluded that mutations in the p53 gene are not necessary in aflatoxin B1 induced hepatocarcinogenesis in non-human primates. It is suggested that the occurrence of mutation in codon 249 of the p53 gene in selective samples of human hepatocellular cancers may indicate involvement of environmental carcinogens other than aflatoxin B1 or that hepatitis B virus-related hepatitis is a prerequisite for aflatoxin B1 induction of G to T transversion in codon 249.
KW  - Aflatoxins
KW  - carcinogenesis
KW  - mutagenesis
KW  - Mycotoxins
KW  - poisoning
KW  - toxicity
KW  - monkeys
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fungal toxins
KW  - toxicosis
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Does β-carotene explain why reduced cancer risk is associated with vegetable and fruit intake?
AU  - Ziegler, R. G.
AU  - Subar, A. F.
AU  - Craft, N. E.
AU  - Ursin, G.
AU  - Patterson, B. H.
AU  - Graubard, B. I.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
SP  - 2060S
EP  - 2066S
SN  - 0008-5472
AD  - Ziegler, R. G.: Environmental Epidemiology Branch and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921447442.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 51 ref. Registry Number: 7235-40-7.  Subject Subsets: Human Nutrition
N2  - A review of the literature indicates that increased intake of vegetables, fruits and carotenoids, and elevated blood levels of β-carotene, are consistently associated with the reduced risk of lung cancer in epidemiologic studies. Epidemiologic research also suggests that carotenoids may reduce the risk of other cancers, although the evidence is less extensive and consistent. The simplest explanation is that β-carotene is protective. However, the possible roles of other carotenoids, other constituents of vegetables and fruits, and associated dietary patterns have not been adequately explored. To evaluate these alternative hypotheses, the authors are undertaking 3 lines of research. (a) With dietary data from the 1987 National Health Interview Survey and the 1982-1984 Epidemiologic Follow-up of the first National Health and Nutrition Examination Study, it has been determined which food groups and nutrients are highly correlated with vegetable and fruit intake. (b) A liquid chromatography method for optimal recovery and resolution of the common carotenoids in blood, specifically lutein, zeaxanthin, β-cryptoxanthin, lycopene, α-carotene and β-carotene, has been developed. (c) In a population-based case-control study of lung cancer in white men in New Jersey, it is being assessed whether estimates of the intake of the individual carotenoids might produce stronger inverse associations than estimates of provitamin A carotenoids based on current food composition tables.
KW  - beta-carotene
KW  - Carcinoma
KW  - intake
KW  - reviews
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Nutrition and cancer
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Metabolic activation and genotoxicity of heterocyclic arylamines.
AU  - Synderwine, E. G.
AU  - Schut, H. A. J.
AU  - Adamson, R. H.
AU  - Thorgeirsson, U. P.
AU  - Thorgeirsson, S. S.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
SP  - 2099S
EP  - 2102S
SN  - 0008-5472
AD  - Synderwine, E. G.: Laboratory of Experimental Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921447472.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 13 ref. Registry Number: 9007-49-2.  Subject Subsets: Human Nutrition
N2  - Because of the potential for human exposure to mutagenic and carcinogenic heterocyclic arylamines (HAA) in the diet, the carcinogenicity of 3 HAAs, 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, is being evaluated by the authors in non-primates, especially cynomolgus monkeys. Concomitant with the carcinogenicity studies, the metabolic processing, disposition and DNA-adduct formation of these compounds are being examined in these monkeys. This report highlights the results from studies in monkeys and from in vitro models examining metabolic activation and genotoxicity of HAAs. The extent of in vivo activation of HAAs in monkeys was assessed by measuring DNA adducts in various tissues. Both 2-amino-3-methylimidazo[4,5-f]quinolone and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine formed high levels of DNA adducts in a number of organs, particularly the liver, kidney and heart. The implications of metabolic activation and DNA-adduct formation for the carcinogenicity of HAAs are discussed.
KW  - Carcinogenesis
KW  - DNA
KW  - foods
KW  - heterocyclic nitrogen compounds
KW  - USA
KW  - monkeys
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - deoxyribonucleic acid
KW  - Nutrition and cancer
KW  - United States of America
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol and cancer.
AU  - Blot, W. J.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
SP  - 2119S
EP  - 2123S
SN  - 0008-5472
AD  - Blot, W. J.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921447476.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 52 ref. Subject Subsets: Human Nutrition
N2  - Although ethanol had generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in man. Risk of oral, pharyngeal, laryngeal, oesophageal and liver cancer are elevated among drinkers, typically in proportion to the amount consumed. Evidence associating colorectal and breast cancer with alcohol drinking is suggestive but awaits confirmation. All types of alcoholic beverages seem to be implicated, pointing to an aetiological role for ethanol or its metabolites. The mechanisms, however, by which alcohol induces cancer in man are not clear. This review summarizes epidemiological studies of alcohol and cancer, focusing primarily on characteristics of the association that may provide clues to causal pathways.
KW  - alcoholic beverages
KW  - Carcinoma
KW  - reviews
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Nutrition and cancer
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Other Produce (QQ070) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.
AU  - Levy, D. D.
AU  - Groopman, J. D.
AU  - Lim, S. E.
AU  - Seidman, M. M.
AU  - Kraemer, K. H.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
IS  - 20
SP  - 5668
EP  - 5673
SN  - 0008-5472
AD  - Levy, D. D.: K. H. Kraemer, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921213344.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The mutagenic spectrum induced by aflatoxin-DNA lesions in DNA repair deficient and repair proficient human cells was investigated. The reactive metabolite aflatoxin B1-8,9-epoxide was synthesized and reacted in vitro with the shuttle vector plasmid pS189. Plasmids were transfected into human fibroblasts and allowed to replicate, and the recovered plasmids were screened in indicator bacteria for plasmid survival and mutations in the supF marker gene. Sequence data were obtained from 71 independently arising mutants recovered from DNA repair deficient xeroderma pigmentosum (XP) cells [XP12BE(SV40)] and 60 mutants recovered from a DNA repair proficient cell line (GM0637). Plasmid survival was lower and mutation frequency higher with the XP cells and the mutation hotspots differed substantially for the 2 cell lines. Most mutations (&gt;90%) were base substitutions at G:C pairs, only about one-half of which were G:C-&gt;T:A transversions, the expected predominant mutation. One-third of the mutations at GG sites and none of those at isolated Gs were G:C-&gt;A:T transitions. Tandem base substitutions also occurred only at GG sites and were found only with XP cells. The location of mutation hotspots with either cell line did not correlate with the level of modification within the sequence as assessed by a DNA polymerase stop assay. It is suggested that the DNA repair deficiency associated with XP can influence not only the overall frequency of mutations but also the distribution of mutations within a gene. The finding of transition mutations exclusively at GG sites may be of predictive value in attempts to link dietary aflatoxin exposure to cancers associated with specific mutations in the c-ras oncogene and the p53 tumour suppressor gene.
KW  - Aflatoxins
KW  - mutagenesis
KW  - Mycotoxins
KW  - toxicity
KW  - fungal toxins
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoid status and the control of keratin expression and adhesion during the histogenesis of squamous metaplasia of tracheal epithelium.
AU  - Lancillotti, F.
AU  - Darwiche, N.
AU  - Celli, G.
AU  - De Luca, L. M.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1992///
VL  - 52
IS  - 22
SP  - 6144
EP  - 6152
SN  - 0008-5472
AD  - Lancillotti, F.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931459771.  Publication Type: Journal Article.  Language: English.  Number of References: 74 ref. Registry Number: 68238-35-7, 9008-18-8, 68-26-8.  Subject Subsets: Human Nutrition
N2  - Vitamin A depletion was induced to define early and late changes during the histogenesis of squamous metaplasia of hamster tracheal epithelium. An early change is the "minimal morphological change" (MMC), in which the mucociliary epithelium is separated from the basement membrane by a continuous layer of basal cells. Immunohistochemistry showed an exclusive localization of keratins K5 and K14 in basal cells of normal and MMC epithelia. At the MMC stage no staining was observed above the basal layer with antibodies to K5, but upon progression of the lesion to a squamous focus all cells from basal to terminally differentiated were positive for K5 and K14. When antibodies to the keratins K6 or K13 were used all cells were negative in the normal MMC epithelium. Successive layers of suprabasal squamous cells found in squamous metaplasia failed to express normal epidermal differentiation marker keratins K1 and K10 but expressed the proliferation marker keratin K6 and the internal stratified epithelium keratin K13, not normally found in the epidermis or trachea. Hamster tracheal epithelial cells could be maintained in culture in serum-free medium for at least 4 weeks in the presence of retinoic acid (RA). In non-RA-containing medium, cells from vitamin A-deficient hamsters showed markedly reduced growth and an increase in expression of keratins K5, K6, K13 and K14. Functional assays demonstrated that hamster tracheal epithelial cells, obtained from non-RA-treated tracheas or maintained in culture, displayed reduced attachment to laminin, compared to RA-treated cells. Immunofluorescence studies did not show a decrease in the α6 integrin subunit, which was localized in the basal aspect of basal cells, or in basement membrane laminin. However, expression of laminin-binding protein 37 decreased as the epithelium changed from pseudostratified to stratified. Therefore, a coordinated pattern of changes in keratin gene expression, and in the expression of laminin-binding protein 37, the precursor to the cell surface laminin receptor 67LR, and in adhesive properties takes place in tracheal epithelium when its phenotype changes from mucociliary to the preneoplastic stage of squamous metaplasia.
KW  - adhesion
KW  - Carcinoma
KW  - cell cultures
KW  - expressivity
KW  - keratin
KW  - nutritional state
KW  - Retinol
KW  - trachea
KW  - hamsters
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - nutritional status
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of a Plasmodium falciparum histone 2A gene.
AU  - Creedon, K. A.
AU  - Kaslow, D. C.
AU  - Rathod, P. K.
AU  - Wellems, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1992///
VL  - 54
IS  - 1
SP  - 113
EP  - 115
SN  - 0166-6851
AD  - Creedon, K. A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920800136.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A P. falciparum gametocyte cDNA library constructed in pcDNAII yielded a clone which encoded histone 2A. The P. falciparum cDNA insert (477 bp), sequenced by the dideoxynucleotide method yielded the 396 bp open reading frame of pfh2a. A single methionine, preceeded by a stop codon, was found to initiate the histone sequence. The sequence encoded a basic protein comprising 132 amino acids, with a predicted MW of 14 100. It had 54.3-76.5% identity with the histones of fungi, protozoa, plants, invertebrates and vertebrates. There was no evidence for the presence of introns. RNA blots probed with radiolabelled pfh2a cDNA identified a 1.4 kb band in the total RNA of gametocytes, zygotes and erythrocytic stage parasites. The size of these bands are thought to indicate that long nucleotide sequences outside the pfh2a coding region are present in the mRNA transcript.
KW  - Genes
KW  - histones
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - DNA sequences
KW  - histone
KW  - histone 2A
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anti-HIV and cytotoxic alkaloids from Buchenavia capitata.
AU  - Beutler, J. A.
AU  - Cardellina, J. H., II
AU  - McMahon, J. B.
AU  - Boyd, M. R.
AU  - Cragg, G. M.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1992///
VL  - 55
IS  - 2
SP  - 207
EP  - 213
SN  - 0163-3864
AD  - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Building 1052, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19920314656.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Horticultural Science; Forestry; Forest Products
N2  - The anti-HIV activity in the organic solvent extract of B. capitata leaves [see Weislow, O. S. et al., Journal of the National Cancer Institute (1989) 81, 577] was traced to a series of known flavonoid alkaloids, which represent a new chemotype for such activity. A bioassay-guided fractionation led to 3 alkaloids, the major constituent being O-demethylbuchenavianine. This compound showed only moderate cytotoxicity against HIV in cultured human lymphoblastoid cells. It was also cytotoxic in the National Cancer Institute human disease oriented in vitro tumour screening panel and produced a pattern of modest differential cellular sensitivity.
KW  - Alkaloids
KW  - Broadleaves
KW  - characterization
KW  - composition
KW  - Cytotoxic compounds
KW  - Foliage
KW  - leaves
KW  - Medicinal plants
KW  - medicinal properties
KW  - Plant composition
KW  - trees
KW  - woody plants
KW  - plants
KW  - eukaryotes
KW  - Combretaceae
KW  - Myrtales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Buchenavia
KW  - Buchenavia capitata
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Non-wood Forest Products (KK540) 
KW  - Non-food/Non-feed Plant Products (SS200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food intake measured by an automated food-selection system: relationship to energy expenditure.
AU  - Rising, R.
AU  - Alger, S.
AU  - Boyce, V.
AU  - Seagle, H.
AU  - Ferraro, R.
AU  - Fontvieille, A. M.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992///
VL  - 55
IS  - 2
SP  - 343
EP  - 349
SN  - 0002-9165
AD  - Rising, R.: National Institutes of Health, 4212 N 16th Street Room 541-A, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19921452528.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - An automated food-selection system with 2 vending machines containing a large variety of foods was used to estimate food intake in 10 men (31±6 years old, 69.2±7.1 kg, 18±7% fat, mean ± s.d.) on a metabolic ward. The effect of carbohydrate, fat and protein intakes on 24 h energy expenditure (24EE) and substrate oxidations was estimated in a respiratory chamber during day 4 of weight maintenance and day 7 of feeding freely. Feeding freely resulted in a 7-day overfeeding of 6468±3824 kJ/day above weight-maintenance requirements, leading to a 2.3±1.2-kg gain. The 10 975±3774 kJ excess energy intake on day 7 of feeding freely caused a 1205±920 kJ/day increase in 24EE (Δ24EE = 0.17 ×Δintake - 695; r = 0.71, P&lt;0.02). Of the excess carbohydrate intake, 74% was oxidized (r = 0.86, P&lt;0.001), whereas excess fat intake was not. It is concluded that carbohydrate and protein stores are regulated whereas excess fat intake is channeled to fat stores.
KW  - energy exchange
KW  - estimation
KW  - Food intake
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytotoxic quassinoids from Cedronia granatensis.
AU  - Tischler, M.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
AU  - Cragg, G. M.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1992///
VL  - 55
IS  - 5
SP  - 667
EP  - 671
SN  - 0163-3864
AD  - Tischler, M.: Laboratory of Drug Discovery Research and Development, National Cancer Institute Building 1052, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19950609390.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref.
N2  - From leaves and twigs of Cedronia granatensis [Picrolemma granatensis].
KW  - chemical composition
KW  - cytotoxicity
KW  - foliage
KW  - forest trees
KW  - leaves
KW  - plant composition
KW  - quassinoids
KW  - trees
KW  - woody plants
KW  - plants
KW  - Simaroubaceae
KW  - eukaryotes
KW  - Sapindales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Simaroubaceae
KW  - chemical constituents of plants
KW  - Picrolemma
KW  - Picrolemma granatensis
KW  - Rutales
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men.
AU  - Micozzi, M. S.
AU  - Brown, E. D.
AU  - Edwards, B. K.
AU  - Bieri, J. G.
AU  - Taylor, P. R.
AU  - Khachik, F.
AU  - Beecher, G. R.
AU  - Smith, J. C., Jr.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992///
VL  - 55
IS  - 6
SP  - 1120
EP  - 1125
SN  - 0002-9165
AD  - Micozzi, M. S.: P. R. Taylor, Cancer Prevention Studies Branch, National Cancer Institute, Executive Plaza North, Suite 211, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921451894.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 7235-40-7.  Subject Subsets: Human Nutrition
N2  - Serial changes in 4 major plasma carotenoid fractions (α-carotene, β-carotene, lutein/zeaxanthin, and lycopene) were estimated in 30 men, 20 to 45 years old, consuming defined daily doses of carotenoids from foods (broccoli, carrots, or tomato juice) or from purified β-carotene in capsules (12 or 30 mg) for 6 weeks while fed on a controlled diet. Compared with baseline, β-carotene increased in the 30- and 12-mg-capsule and carrot groups whereas α-carotene increased in the carrot group and lutein increased in the broccoli group. Lower lutein concentrations in recipients of β-carotene capsules suggested an interaction between these 2 carotenoids. Lycopene decreased in all groups except the tomato-juice group. Total carotenoid concentration changes only reflected the large increases in β-carotene concentrations and not the smaller changes observed in other individual carotenoids. Overall, purified β-carotene produced a greater plasma response than did similar quantities of carotenoids from food sources.
KW  - beta-carotene
KW  - blood
KW  - broccoli
KW  - carotenoids
KW  - carrots
KW  - intake
KW  - Men
KW  - supplements
KW  - tomato juice
KW  - Brassica oleracea
KW  - Daucus carota
KW  - Man
KW  - Brassica
KW  - Brassicaceae
KW  - Capparidales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Daucus
KW  - Apiaceae
KW  - Apiales
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Araliales
KW  - calabrese
KW  - Capparales
KW  - tetraterpenoids
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A brief overview of human energy metabolism and its relationship to essential obesity.
AU  - Ravussin, E.
AU  - Bogardus, C.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992///
VL  - 55
IS  - Suppl. 1
SP  - 242S
EP  - 245S
SN  - 0002-9165
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19921450020.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Human Nutrition
N2  - Human energy metabolism is reviewed in relation to essential obesity. Topics covered include determinants of daily energy expenditure, low metabolic rate as a risk factor for weight gain, and components of daily energy expenditure.
KW  - Energy metabolism
KW  - obesity
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of a cryptic intron in the Plasmodium vivax Duffy binding protein gene.
AU  - Adams, J. H.
AU  - Fang, X. D.
AU  - Kaslow, D. C.
AU  - Miller, L. H.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1992///
VL  - 56
IS  - 1
SP  - 181
EP  - 183
SN  - 0166-6851
AD  - Adams, J. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930802439.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A revised deduced amino acid sequence of the P. vivax Duffy binding protein is presented, based as new data from polymerase chain reaction-amplified reverse-transcribed mRNA. When the nucleotide sequence of the genes encoding the Duffy binding protein of P. vivax and P. knowlesi β gene were aligned, the sequences were similar before and after, but not within the region where the P. knowlesi β intron is found. P. vivax cDNA was synthesized from total cellular RNA with an antisense oligonucleotide 100 bp downstream from the possible intron and then was amplified by PCR using the cDNA primer and a sense oligonucleotide 500 bp upstream of a possible intron. The major cDNA PCR product was (135 bp) smaller than the PCR product of a genomic clone, indicating that the intron was spliced. The cDNA PCR product was sequenced directly using radiolabelled internal primers by Taq polymerase-based cycle sequencing. The cDNA sequence confirmed that the intron was removed in the major P. vivax transcript giving rise to an amino acid sequence homologous to the P. knowlesi β gene.
KW  - amino acid sequences
KW  - COMPLEMENTARY DNA
KW  - Genes
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - Polymerase chain reaction
KW  - proteins
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium vivax
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - Duffy binding
KW  - Duffy binding protein
KW  - PCR
KW  - protein sequences
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - α-Tubulin II is a male-specific protein in Plasmodium falciparum.
AU  - Rawlings, D. J.
AU  - Fujioka, H.
AU  - Fried, M.
AU  - Keister, D. B.
AU  - Aikawa, M.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1992///
VL  - 56
IS  - 2
SP  - 239
EP  - 250
SN  - 0166-6851
AD  - Rawlings, D. J.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930802715.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The tubulin gene family in P. falciparum consists of one β-tubulin and 2 α-tubulin genes (α-tubulin I and II). Data is presented which indicated that α-tubulin II is expressed only in male sexual stage parasites. An IgM MAb, 5E7, specifically reacted with stage III (day 4-5) to mature (day 10-11) male gametocytes and with emerging, exflagellating, or freely moving male gametes. No reactivity was detected in female gametocytes, female gametes, sporozoites, or asexual parasites. MAb 5E7 also specifically recognized male gametes of the avian parasite Plasmodium gallinaceum, and immunoblotted a 50 000 MW protein in extracts of male gametes from both species. This 50 000 MW antigen was localized by immunoelectron microscopy to axonemes of male gametes in a pattern similar to that obtained with anti-α- and anti-β-tubulin antibodies. Furthermore, MAb 5E7 specifically reacted with recombinant α-tubulin II protein obtained using the PCR-amplified α-tubulin II gene from a gametocyte-specific cDNA library. The sex-specific expression of α-tubulin II and its localization to axoneme of the male parasite suggest a role for this molecule in the morphologic changes that occur during exflagellation and in the motility of the parasite.
KW  - Biochemistry
KW  - Human diseases
KW  - Monoclonal antibodies
KW  - parasites
KW  - Sex differences
KW  - tubulin
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - alpha-tubulin II
KW  - male gametes
KW  - male gametocytes
KW  - sex-specific
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802715&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Brain transfer coefficients for 67Ga: comparison to 55Fe and effect of calcium deficiency.
AU  - Murphy, V. A.
AU  - Rapoport, S. I.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1992///
VL  - 58
IS  - 3
SP  - 898
EP  - 902
SN  - 0022-3042
AD  - Murphy, V. A.: Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19931464945.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 7440-70-2, 7440-55-3, 7439-89-6.  Subject Subsets: Human Nutrition
N2  - The transfer coefficients (Kin) for the uptake of gallium-67 into brain and cerebrospinal fluid (CSF) were estimated in unanaesthetized male Fischer-344 rats given adult normal or low in calcium diets. Kin for 67Ga was also compared with transfer coefficients for uptake of of iron-55 and 125I-albumin in controls. The value of CSF67Ga Kin was 3 × 10-7 ml g-1 s-1 and was 50% larger in low-Ca rats. Brain regional Kin values for 67Ga were 3-9 × 10-7 ml g-1 s-1 with no difference in Kin between normal and low-Ca rats. CSF Kin values for 55Fe were 40% and those for albumin were 15% of Kin for 67Ga. For brain, Kin values for 55Fe were 15 to 40% smaller than for 67Ga, but for albumin the Kin values were 85% less than for 67Ga. 67Ga was 99% bound to plasma proteins, whereas 55Fe was 99.9% bound. The results indicate that metals that are primarily bound to transferrin enter the CSF and brain very slowly. Uptake of both metals was faster than albumin, which may indicate that metal bound to small chelates contributes significantly to brain uptake. Ca deficiency does not enhance entry of Ga into the brain.
KW  - blood protein
KW  - brain
KW  - calcium
KW  - cerebrospinal fluid
KW  - deficiency
KW  - Gallium
KW  - Iron
KW  - Isotopes
KW  - Transfer
KW  - uptake
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - plasma protein
KW  - serum protein
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464945&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment and developmental therapeutics in aspergillosis. 1. Amphotericin B and its derivatives.
AU  - St. Georgiev, V.
JO  - Respiration
JF  - Respiration
Y1  - 1992///
VL  - 59
IS  - 5
SP  - 291
EP  - 302
SN  - 0025-7931
AD  - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200527.  Publication Type: Journal Article.  Language: English.  Number of References: 139 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The treatment of infections caused by Aspergillus spp. with amphotericin B, its clinical efficacy, toxicity and routes of administration are reviewed. Liposome-encapsulated amphotericin B, amphotericin B complexes with deoxycholate and cholesterol sulfate, combinations of amphotericin B with other drugs and amphotericin B esters are discussed. The anti-Aspergillus activity of other polyene antibiotics (nystatin, hamycin, natamycin, ambruticin), benzo[a]naphthacenequinone antibiotics, nikkomycins and cilofungins are also considered.
KW  - amphotericin B
KW  - reviews
KW  - therapy
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200527&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment and developmental therapeutics in aspergillosis. 2. Azoles and other antifungal drugs.
AU  - St. Georgiev, V.
JO  - Respiration
JF  - Respiration
Y1  - 1992///
VL  - 59
IS  - 5
SP  - 303
EP  - 313
SN  - 0025-7931
AD  - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200528.  Publication Type: Journal Article.  Language: English.  Number of References: 131 ref. Registry Number: 23593-75-1, 86386-73-4, 84625-61-6, 65277-42-1, 22916-47-8.  Subject Subsets: Medical & Veterinary Mycology
N2  - The use of azole derivatives (including clotrimazole, miconazole, ketoconazole, fluconazole and itraconazole), miscellaneous antifungal compounds (such as flucytosine) and granulocyte colony-stimulating factor in the treatment of Aspergillus infections is reviewed. Sodium (potassium) iodide therapy of aspergilloma and therapy of allergic bronchopulmonary aspergillosis and Aspergillus-induced otomycosis are also considered.
KW  - allergic bronchopulmonary aspergillosis
KW  - allergies
KW  - azoles
KW  - clotrimazole
KW  - ears
KW  - fluconazole
KW  - infections
KW  - itraconazole
KW  - ketoconazole
KW  - lungs
KW  - miconazole
KW  - therapy
KW  - Aspergillus
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - ABPA
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200528&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic association of mating types and virulence in Cryptococcus neoformans.
AU  - Kwon-Chung, K. J.
AU  - Edman, J. C.
AU  - Wickes, B. L.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1992///
VL  - 60
IS  - 2
SP  - 602
EP  - 605
SN  - 0019-9567
AD  - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211030.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A pair of congenic C. neoformans strs., B-4476 (a mating type) and B-4500 (α mating type), that presumably differ only in mating type was constructed. This pair and their progeny, 5 α type and 5 a type, were tested for virulence in mice. In the parent strains as well as the progeny, α type was clearly more virulent than a type. In addition, death tended to occur earlier among the α-strain-infected mice that died than among the mice that died by infection caused by a strs. It is suggested that there is genetic association of virulence with mating type in C. neoformans.
KW  - genetics
KW  - infections
KW  - pathogenicity
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interactions between extracellular Borrelia burgdorferi proteins and non-Borrelia-directed immunoglobulin M antibodies.
AU  - Dorward, D. W.
AU  - Huguenel, E. D.
AU  - Davis, G.
AU  - Garon, C. F.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1992///
VL  - 60
IS  - 3
SP  - 838
EP  - 844
SN  - 0019-9567
AD  - Dorward, D. W.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940503577.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 308067-57-4.  Subject Subsets: Medical & Veterinary Entomology
N2  - Previous work showed that outer surface protein A (OspA) and OspB of B. burgdorferi may occur within an extracellular multiprotein complex, which was resolved by electrophoresis as an 83-kDa major extracellular protein band. To characterize the 83-kDa band the N terminus of the predominant peptide in the band was sequenced and the interaction between the associated proteins examined. Peptide sequence and amino acid composition comparisons showed identity with the heavy chain of IgM. Reduction sensitivity experiments and the recognition of the band by antibodies specific for rabbit µ chain indicated that the multiprotein complex contained pentameric IgM. Immunoelectron microscopy showed that anti-µ chain antibodies and monoclonal antibodies to OspA and OspB bound to extracellular amorphous material surrounding cells. Furthermore, the Osps coprecipitated with either non-specific polyclonal rabbit IgM antibodies or with murine monoclonal anti-human serum albumin IgM antibodies, using insoluble anti-µ chain antibody conjugates. Although the apparent 83-kDa complex was stable under conditions of chelation and concentrated salts, it was disrupted by treatment with neuraminidase. The results indicated that extracellular B. burgdorferi proteins, including OspA and OspB, interact with IgM. The association is apparently not a classic antibody-antigen interaction but may result from other mechanisms.
KW  - amino acid sequences
KW  - antigen antibody reactions
KW  - antigens
KW  - IgM
KW  - immunoglobulins
KW  - proteins
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenic reactions
KW  - antigenicity
KW  - bacterium
KW  - gamma-globulins
KW  - immune globulins
KW  - immunogens
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940503577&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformans.
AU  - Varma, A.
AU  - Edman, J. C.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1992///
VL  - 60
IS  - 3
SP  - 1101
EP  - 1108
SN  - 0019-9567
AD  - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211460.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology; Agricultural Biotechnology
N2  - C. neoformans ura5 mutants were transformed with linearized or circular plasmids containing the C. neoformans orotidine monophosphate pyrophosphorylase gene. Following electroporation, randomly isolated transformants were analysed for the mitotic and meiotic stability of uracil prototrophy. All stable transformants tested showed non-specific ectopic integration. Uracil prototrophy in these transformants was stable through meiosis. Some of the stable transformants showed integration of both URA5 and vector sequences, while others lacked any vector sequences. Unstable transformants exhibited the presence of an autonomously replicating plasmid which had undergone significant sequence rearrangement. The autonomously replicating plasmid in the transformants was observed to be the same size or smaller than the transforming plasmid, was maintained in a linear form and had acquired a genomic sequence(s) with homology to a sequence(s) on all the chromosomes. The conservation of a 300-bp sequence at the 5′ end of the URA5 gene was observed in all the rearranged plasmids. It is suggested that there are mechanisms of plasmid maintenance in C. neoformans that are different from those reported for other yeasts. The ura5 mutant was significantly less virulent than the wild type. The transformants did not recover virulence regardless of prototrophic stability.
KW  - Biotechnology
KW  - gene transfer
KW  - genetics
KW  - Plasmids
KW  - transformation
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211460&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Modulation of a surface antigen of Entamoeba histolytica in response to bacteria.
AU  - Bhattacharya, A.
AU  - Ghildyal, R.
AU  - Prasad, J.
AU  - Bhattacharya, S.
AU  - Diamond, L. S.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1992///
VL  - 60
IS  - 4
SP  - 1711
EP  - 1713
SN  - 0019-9567
AD  - Bhattacharya, A.: L.S. Diamond, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878764.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology
N2  - Changes in the cell surface of E. histolytica were examined with MAb, 2D7.10, which selectively recognizes carbohydrate epitopes in some axenic amoebic strains. While high-level expression of this epitope was observed in axenic amoebae, it was either absent or present only in small amounts in xenic amoebae. Furthermore, reassociation of the axenic amoebae with intestinal flora resulted in loss of the 2D7.10 epitope. The data suggest that surface antigens of E. histolytica can be modulated in response to bacteria and may provide an explanation for the observed influence of bacteria on amoebic virulence.
KW  - antigens
KW  - Epitopes
KW  - Human diseases
KW  - interactions
KW  - Monoclonal antibodies
KW  - parasites
KW  - Pathogenicity
KW  - bacteria
KW  - Endamoebidae
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - prokaryotes
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Endamoebidae
KW  - antigenic determinants
KW  - antigenicity
KW  - bacterium
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878764&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Virulence, serotype, and molecular characteristics of environmental strains of Cryptococcus neoformans var. gattii.
AU  - Kwon-Chung, K. J.
AU  - Wickes, B. L.
AU  - Stockman, L.
AU  - Roberts, G. D.
AU  - Ellis, D.
AU  - Howard, D. H.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1992///
VL  - 60
IS  - 5
SP  - 1869
EP  - 1882
SN  - 0019-9567
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211749.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Four strains of C. neoformans var. gattii originating from Eucalyptus camaldulensis, 3 from Australia and 1 from San Francisco, were tested for their serotype, virulence for mice and a number of genetic and molecular characteristics. All were found to be serotype B and showed significantly higher virulence for mice than did the type strains of C. neoformans var. gattii and Filobasidiella neoformans var. bacillispora, which were obtained from human cryptococcosis cases. Electrophoretic karyotypes of the strains from Australia were identical, although they were collected from sites at least 15-500 km apart. The electrophoretic karyotype of the strain from San Francisco was the same as that of the Australian isolates except for the mobility of one chromosome. On the contrary, no 2 isolates of serotype B (of a total of 11) from clinical sources were the same, regardless of their geographical origin. Furthermore, none of the clinical isolates showed a chromosomal banding patttern identical to that of Eucalyptus-originated strains. The Eucalyptus-originated strains failed to form dikaryons when crossed with the tester strains of the 2 varieties of F. neoformans. Hybridization analysis with a nucleic acid probe (AccuProbe) showed signals of equal intensity for clinical strains and the Eucalyptus-originated strains. Various fungi phylogenetically related to C. neoformans, including a phenol oxidase-positive strain of C. laurentii obtained from E. camaldulensis, were negative in the nucleic acid hybridization test. It is concluded that in spite of karyotypic differences and the lack of dikaryon formation with the tester strains of F. neoformans, Eucalyptus-originated C. neoformans var. gattii is the same organism as those isolated from cases of human infection. Furthermore, the C. neoformans culture confirmation test using a commercial nucleic acid probe is specific for C. neoformans.
KW  - contamination
KW  - genetics
KW  - immunology
KW  - karyotypes
KW  - pathogenicity
KW  - serotypes
KW  - Australia
KW  - USA
KW  - Cryptococcus gattii
KW  - Eucalyptus
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Cryptococcus neoformans
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Myrtaceae
KW  - Myrtales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - North America
KW  - America
KW  - Cryptococcus neoformans var. gattii
KW  - fungus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211749&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Opportunistic infections and retrovirus-induced immunodeficiency: studies of acute and chronic infections with Toxoplasma gondii in mice infected with LP-BM5 murine leukemia viruses.
AU  - Gazzinelli, R. T.
AU  - Hartley, J. W.
AU  - Fredrickson, T. N.
AU  - Chattopadhyay, S. K.
AU  - Sher, A.
AU  - Morse, H. C., III
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1992///
VL  - 60
IS  - 10
SP  - 4394
EP  - 4401
SN  - 0019-9567
AD  - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920801634.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - Mice infected with LP-BM5 murine leukaemia viruses develop a syndrome, termed mouse acquired immune deficiency syndrome (MAIDS), characterized by increasingly severe immunodeficiency and progressive lymphoproliferation. Virus-infected C57BL/6 mice were examined for the ability to resist acute infection and to control chronic infection with T. gondii. Mice infected with the retroviruses for 2 or 4 weeks responded normally to challenge with the parasite, but mice inoculated 8 or 12 weeks after viral infection died with acute disease due to T. gondii. Increased sensitivity to acute infection was associated with a reduced ability to produce gamma interferon (IFN-γ) and with established changes in CD4+ T-cell function. Mice latently infected with T. gondii and then inoculated with the retrovirus mixture were found to reactivate the parasite infection, with 30 to 40% of dually infected animals dying between 5 and 16 weeks after viral infection. Reactivation was associated with reduced proliferation and impaired production of IFN-γ in response to stimulation with soluble T. gondii antigens or to concanavalin A. Continuing resistance to lethal reactivation in the remaining mice was shown to require CD8+ T cells and expression of IFN-γ. In addition, it was found that chronic infection with T. gondii altered the course of MAIDS by inhibiting the progression of splenomegaly and immunodeficiency and reducing the expression of both the helper and aetiological defective viruses. These results support previous studies which indicate that infection with T. gondii is controlled by synergistic interactions between CD4+ and CD8+ T cells, the functions of which are progressively impaired during the course of MAIDS.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - animal models
KW  - Disease models
KW  - Experimental infections
KW  - Human diseases
KW  - immune response
KW  - immunocompromised hosts
KW  - Immunology
KW  - Interferon
KW  - Laboratory animals
KW  - Opportunistic infections
KW  - parasites
KW  - T lymphocytes
KW  - Toxoplasmosis
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - protozoa
KW  - Rodents
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - AIDS
KW  - Function
KW  - immunity reactions
KW  - immunological reactions
KW  - Murine
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801634&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease.
AU  - Cahour, A.
AU  - Falgout, B.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1992///
VL  - 66
IS  - 3
SP  - 1535
EP  - 1542
SN  - 0022-538X
AD  - Cahour, A.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940500292.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The cleavage mechanism utilized for processing of the NS3-NS4A-NS4B-NS5 domain of the dengue virus polyprotein was studied by using the vaccinia virus expression system. Recombinant vaccinia viruses vNS2B-NS3-NS4A-NS4B-NS5, vNS3-NS4A-NS4B-NS5, vNS4A-NS4B-NS5 and vNS4B-NS5 were constructed. These recombinants were used to infect cells, and the labelled lysates were analysed by immunoprecipitation. Recombinant vNS2B-NS3-NS4A-NS4B-NS5 expressed the authentic NS3 and NS5 proteins, but the other recombinants produced uncleaved polyproteins. These findings indicate that NS2B is required for processing of the downstream nonstructural proteins, including the NS3/NS4A and NS4B/NS5 junctions, both of which contain a dibasic amino acid sequence preceeding the cleavage site. The flavivirus NS4A/NS4B cleavage site follows a long hydrophobic sequence. The polyprotein NS4A-NS4B-NS5 was cleaved at the NS4/NS4B junction in the absence of other dengue virus functions. One interpretation for this finding is that NS4A/NS4B cleavage is mediated by a host protease, presumably a signal peptidase. Although vNS3-NS4A-NS4B-NS5 expressed only the polyprotein, earlier results demonstrated that cleavage at the NS4A/NS4B junction occurred when an analogous recombinant, vNS3-NS4A-84%NS4B, was expressed. Thus, it appears that uncleaved NS3 plus NS5 inhibit NS4A/NS4B cleavage presumably because the putative signal sequence is not accessible for recognition by the responsible protease. Finally, recombinants that expressed an uncleaved NS4B-NS5 polyprotein, such as vNS4A-NS4B-NS5 or vNS4B-NS5, produced NS5 when complemented with vNS2B-30%NS3 or with vNS2B plus v30%NS3. These results indicate that cleavage at the NS4B/NS5 junction can be mediated by NS2B and NS3 in trans.
KW  - arboviruses
KW  - cleavage
KW  - proteinases
KW  - viral proteins
KW  - dengue virus
KW  - Flavivirus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - polyproteins
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500292&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bovine immunodeficiency-like virus encodes factors which trans activate the long terminal repeat.
AU  - Pallansch, L. A.
AU  - Lackman-Smith, C. S.
AU  - Gonda, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1992///
VL  - 66
IS  - 5
SP  - 2647
EP  - 2652
SN  - 0022-538X
AD  - Pallansch, L. A.: M. A. Gonda, Laboratory of Cell and Molecular Structure, Program Resources, Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1202, USA.
N1  - Accession Number: 19922268493.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Subject Subsets: Veterinary Science; Agricultural Biotechnology
N2  - Lentiviruses are known to encode factors which trans activate expression from the viral long terminal repeat (LTR); the primary trans activator is the tat gene product. One of the putative accessory genes (tat) of the bovine immunodeficiency-like virus (BIV) bears sequence similarity to other lentivirus tat genes. This finding suggests that BIV may encode a trans-activating protein capable of stimulating LTR-directed gene expression. To test this hypothesis in vitro, BIV LTR-chloramphenicol acetyltransferase (CAT) reporter gene plasmids were constructed and transfected into 3 cell lines from canine, bovine or lapine tissues that are susceptible to BIV infection. The level of BIV LTR-directed CAT gene expression was increased in BIV-infected cells compared with uninfected cells. The relatively high basal-level expression of BIV LTR-CAT in uninfected canine and bovine cell lines suggests that cellular factors play a role in regulating BIV LTR-directed gene expression. Additionally, by using a clonal canine cell line in which the BIV LTR-CAT plasmid in stably expressed, BIV LTR-directed CAT expression is increased 15- to 90-fold by cocultivation with BIV-infected cells, supporting the notion that BIV encodes a trans activator. The relative specificity of this viral activation was assessed by coculturing the clonal BIV LTR-CAT cell line with bovine leukosis virus- or bovine syncytial virus-infected cells; these bovine retroviruses increased expression from the BIV LTR only two- to threefold. Thus, BIV LTR regulatory elements in infected cells, like those of human immunodeficiency virus type 1 and other lentiviruses, are trans activated, presumably through the action of a Tat-like protein and cellular factors.
KW  - Biotechnology
KW  - Cell culture
KW  - Gene expression
KW  - Molecular biology
KW  - Nucleotide sequences
KW  - Regulation
KW  - Transactivation
KW  - Bovine immunodeficiency virus
KW  - LENTIVIRUS
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA sequences
KW  - Long terminal repeat
KW  - transcriptional activation
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922268493&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunological characterization of the gag gene products of bovine immunodeficiency virus.
AU  - Battles, J. K.
AU  - Hu, M. Y.
AU  - Rasmussen, L.
AU  - Tobin, G. J.
AU  - Gonda, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1992///
VL  - 66
IS  - 12
SP  - 6868
EP  - 6877
SN  - 0022-538X
AD  - Battles, J. K.: Laboratory of Cell and Molecular Structure, Program Resources, Inc./Dyn Corp., National Cancer Institute Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702-1201 USA.
N1  - Accession Number: 19932278411.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - The bovine immunodeficiency virus (BIV) gag gene encodes a 53-kDa precursor (Pr53gag) that is involved in virus particle assembly and is further processed into the putative matrix (MA), capsid (CA), and nucleocapsid (NC) functional domains in the mature virus. Gag determinants are also found in the Gag-Pol polyprotein precursor. To immunologically identify the major precursors and processed products of the BIV gag gene, monospecific rabbit sera to recombinant BIV MA protein and Pr53gag and peptides predicted to correspond to the CA and NC proteins and the MA-CA cleavage site were developed and used in immunoprecipitations and immunoblots of BIV antigens. Monospecific antisera to native and recombinant human immunodeficiency virus type 1 proteins were also used to identify analogous BIV Gag proteins and to determine whether cross-reactive epitopes were present in the BIV Gag precursors or processed products. The BIV MA, CA, and NC Gag proteins were identified as p15, p26, and p13, respectively. In addition to BIV Pr53gag, the major Gag precursor, 2 other Gag-related precursors of 170 and 49 kDa were identified that have been designated pPr170gag-pol and Pr49gag, respectively; pPr170gag-pol is the Gag-Pol polyprotein precursor, and Pr49gag is the transframe Gag precursor present in pPr170gag-pol. Several alternative Gag cleavage products were also observed, including p23, which contain CA and NC determinants, and p10, which contains a peptide sequence conserved in the CA proteins of most lentiviruses. The monospecific antisera to human immunodeficiency virus type 1 CA (p24) and NC (p7) proteins showed cross-reactivity to and aided in the identification of analogous BIV proteins. Based on these results, a scheme for the processing of BIV Gag precursors is proposed.
KW  - coat proteins
KW  - epitopes
KW  - Gag protein
KW  - Gene expression
KW  - Immunoblotting
KW  - Immunology
KW  - matrix proteins
KW  - nucleocapsid proteins
KW  - viral diseases
KW  - viral proteins
KW  - Bovine immunodeficiency virus
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenic determinants
KW  - capsid proteins
KW  - viral infections
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932278411&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutational analysis of the octapeptide sequence motif at the NS1-NS2A cleavage junction of dengue type 4 virus.
AU  - Pethel, M.
AU  - Falgout, B.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1992///
VL  - 66
IS  - 12
SP  - 7225
EP  - 7231
SN  - 0022-538X
AD  - Pethel, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950506330.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
N2  - It has previously been shown that proper processing of dengue type 4 virus NS1 from the NS1-NS2A region of the viral polyprotein requires a hydrophobic N-terminal signal and the downstream NS2A. Results from deletion analysis indicate that a minimum length of 8 amino acids at the C terminus of NS1 is required for cleavage at the NS1-NS2A junction. Comparison of this 8-amino-acid sequence with the corresponding sequences of other flaviviruses suggests a consensus cleavage sequence of Met/Leu-Val-Xaa-Ser-Xaa-Val-Xaa-Ala. Site-directed mutagenesis was performed to construct mutants of NS1-NS2A which contained a single amino acid substitution at different positions of the consensus cleavage sequence or at the immediate downstream position. 3-8 different substitutions were made at each position. A total of 50 NS1-NS2A mutants were analyzed for their cleavage efficiency relative to that of the wild-type dengue type 4 virus sequence. As predicted, nearly all substitutions at position P1, P3, P5, P7 and P8, occupied by conserved amino acids, yielded low levels of cleavage, with the exception that Pro or Ala substituting for Ser (P5) was tolerated. Substitutions of an amino acid at the remaining positions occupied by nonconserved amino acids generally yielded high levels of cleavage. Some substitutions at nonconserved positions were, however, not tolerated. For example, substitution of Gly or Glu for Gln (P4) and substitution of Val or Glu for Lys (P6) each yielded a low level of cleavage. Overall, these data support the proposed cleavage sequence motif deduced by comparison of sequences among the flaviviruses. This study also showed that in addition to the 8-amino-acid sequence, the amino acid immediately following the NS1-NS2A cleavage site plays a role in cleavage.
KW  - amino acid sequences
KW  - amino acids
KW  - arboviruses
KW  - cleavage
KW  - mutants
KW  - peptides
KW  - dengue 4 virus
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506330&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Conservation of repeating structures in the PfEMP2/MESA protein of Plasmodium falciparum.
AU  - Saul, A.
AU  - Yeganeh, F.
AU  - Howard, R. J.
JO  - Immunology and Cell Biology
JF  - Immunology and Cell Biology
Y1  - 1992///
VL  - 70
IS  - 5
SP  - 353
EP  - 355
SN  - 0818-9641
AD  - Saul, A.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19950806498.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A large antigenic protein, referred to as MESA, PfEMP2 or PP330, accumulates under the plasma membrane of erythrocytes infected with mature asexual stages of Plasmodium falciparum. Sequences from the gene coding this protein in the Malayan Camp isolate of P. falciparum are described and compared with the full sequence previously described for the FCQ27/PNG isolate, which is dominated by a complicated set of repeats. The sequences from the Malayan Camp isolate show that, unlike several other malarial proteins which have variant repeats (such as the S antigens), the repeats in MESA/PfEMP2 are conserved.
KW  - antigens
KW  - erythrocytes
KW  - genes
KW  - merozoites
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - strains
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - biochemical genetics
KW  - blood red cells
KW  - DNA sequences
KW  - immunogens
KW  - merozoite surface antigens
KW  - PfEMP2 repeats
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806498&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and characterization of a novel multicopy, repetitive sequence of Plasmodium falciparum, REP51.
AU  - Saul, A.
AU  - Yeganeh, F.
AU  - Howard, R. J.
JO  - Immunology and Cell Biology
JF  - Immunology and Cell Biology
Y1  - 1992///
VL  - 70
IS  - 5
SP  - 357
EP  - 359
SN  - 0818-9641
AD  - Saul, A.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19950806499.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology
N2  - A genomic library of Plasmodium falciparum was constructed by digestion of DNA from the Malayan Camp Aotus monkey-adapted isolate under conditions which gave gene-sized fragments. Four to 16 kb-sized fragments were separated by agarose gel electrophoresis and cloned. An array of 450 clones containing inserts was prepared and characterized by examination of the Sau3AI digestion profiles of the plasmid DNA of 250 of these clones and by hybridization of the inserts from selected clones to the whole array. Three multicopy families were found, of which 2 corresponded to previously described multicopy sequences in the P. falciparum genome. Cloning and characterization of a novel multicopy repetitive sequence (REP51) from members of the third family are described.
KW  - DNA
KW  - DNA libraries
KW  - electrophoresis
KW  - genes
KW  - genomes
KW  - multigene families
KW  - nucleotide sequences
KW  - parasites
KW  - repetitive DNA
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cloning
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806499&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transforming growth factor-alpha in human hepatocellular carcinoma and coexpression with hepatitis B surface antigen in adjacent liver.
AU  - Hsia, C. C.
AU  - Axiotis C. A.
AU  - Di Bisceglie, A. M.
AU  - Tabor, E.
JO  - Cancer
JF  - Cancer
Y1  - 1992///
VL  - 70
IS  - 5
SP  - 1049
EP  - 1056
SN  - 0008-543X
AD  - Hsia, C. C.: (E. Tabor) National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050154.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The mechanisms by which hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) are not known. Transforming growth factor-alpha (TGF-α), a regulator of growth and regeneration in rat liver that can be found in high levels in some human cancers, theoretically could play such an intermediate role in the development of HCC. The authors evaluated the expression of TGF-α and its relation to the HBV antigens in human HCC and adjacent non-tumourous livers from 33 patients from the USA and China using immunoperoxidase staining of paraffin-embedded sections. They detected TGF-α in HCC from 27 of 33 (82%) patients; the frequencies were similar in patients from the USA and China. TGF-α was detected in HCC more frequently in patients whose adjacent non-tumourous livers had detectable hepatitis B surface antigen (HBsAg) and/or hepatitis B core antigen (HBcAg) than in those whose adjacent livers lacked HBsAg and HBcAg. Detection of TGF-α was not affected by tumour size, histological type, or grade. TGF-α was detected in adjacent non-tumourous livers from 31 of 33 patients (94%). Co-expression at a high intensity of TGF-α and HBsAg in the same hepatocytes could be demonstrated by specific staining of consecutively cut sections for 17 of 33 patients (52%). TGF-α is expressed at a high level in 82% of human HCC. Localization of HBsAg within the same hepatocytes as TGF-α suggests a possible interaction between HBV and TGF-α during hepatocarcinogenesis in humans. Stimulation of TGF-α expression could be part of a chain of events by which HBV contributes to the development of HCC in some patients. [An interesting study.]From AS/Anna Korczak-Rogon´
KW  - growth factors
KW  - hepatitis B
KW  - liver
KW  - neoplasms
KW  - cancer sites
KW  - cancers
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050154&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Patterns of infection in patients with aplastic anemia and the emergence of Aspergillus as a major cause of death.
AU  - Weinberger, M.
AU  - Elattar, I.
AU  - Marshall, D.
AU  - Steinberg, S. M.
AU  - Redner, R. L.
AU  - Young, N. S.
AU  - Pizzo, P. A.
JO  - Medicine (Baltimore)
JF  - Medicine (Baltimore)
Y1  - 1992///
VL  - 71
IS  - 1
SP  - 24
EP  - 43
SN  - 0025-7974
AD  - Weinberger, M.: P. A. Pizzo, Infectious Disease Section, Pediatric Branch, Clinical Oncology Program, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921212361.  Publication Type: Journal Article.  Language: English.  Number of References: 81 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Patterns of infection were retrospectively studied in 150 patients (60% male, mean age 33.6 yrs) with aplastic anaemia admitted during Jan. 1978-Dec. 1989 for immunosuppressive therapy. A total of 103 patients developed 1 or more febrile episodes during the study period. The risk factors for developing a febrile episode included a low absolute neutrophil count (ANC) and absolute monocyte count (AMC) at admission and the presence of an indwelling central venous catheter. A total of 289 febrile events were studied, including unexplained fever in 89 (31%), microbiologically documented infection in 137 (47%) and clinically documented infection (CDI) in 63 patients (22%). Among CDI events, bacteria were the most commonly defined aetiological agent (67%), followed by fungi (23%), viruses (7%) and parasites (Pneumocystis carinii) (3%). 21 patients (15%) developed invasive fungal infections due to Aspergillus (A. flavus, A. fumigatus, A. nidulans, Aspergillus sp.) in 11, Candida (C. albicans, Torulopsis glabrata, C. tropicalis, C. lusitaniae) in 7; and both in 3, which were fatal in 19 (90%). Fungal infections accounted for 30% of the secondary infectious events and for 55% of fatal infectious events. The only identifiable risk factors for developing a fungal infection were the degree of neutropenia and monocytopenia at initial admission or final evaluation. Invasive pulmonary aspergillosis developed despite empirical amphotericin B therapy and was associated with a high incidence of fatal pulmonary haemorrhage (10 of 13 patients). Infection was responsible for 36 (62%) of the deaths observed during the study period and haemorrhage alone for 4 (7%). However, 20 of the patients who died of infection had concomitant haemorrhage. It is concluded that invasive fungal infections, predominantly with Aspergillus and Candida, emerged in this study as the major causes of mortality in patients with aplastic anaemia.
KW  - aplastic anaemia
KW  - hosts
KW  - infections
KW  - predisposition
KW  - USA
KW  - Aspergillus
KW  - Aspergillus flavus
KW  - Aspergillus fumigatus
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida lusitaniae
KW  - Candida tropicalis
KW  - Emericella nidulans
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Aspergillus
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Torulopsis
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Emericella
KW  - aplastic anemia
KW  - Aspergillus nidulans
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212361&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Localisation of hypoxanthine phosphoribosyl transferase in the malaria parasite Plasmodium falciparum.
AU  - Shahabuddin, M.
AU  - Günther, K.
AU  - Lingelbach, K.
AU  - Aikawa, M.
AU  - Schreiber, M.
AU  - Ridley, R. G.
AU  - Scaife, J. G.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1992///
VL  - 74
IS  - 1
SP  - 11
EP  - 19
SN  - 0014-4894
AD  - Shahabuddin, M.: Malaria Section, Building 4, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920877134.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Hypoxanthine phosphoribosyl transferase of P. falciparum was located in parasites and parasite-infected erythrocytes by antibody probing. The probe was a polyclonal rabbit antiserum produced against the parasite enzyme in Escherichia coli. The enzyme was associated with membrane-bound compartments in merozoites and asexual blood parasites. In particular, indirect immunofluorescence studies showed the enzyme localised in vesicle-like structures within the cytoplasm of the infected erythrocyte. This is the first time a P. falciparum protein of defined metabolic function has been tracked to a site outside the parasite cytosol. Studies on the targeting of the enzyme using a cell-free system suggest that the protein reaches its destination via a route different from the normal secretory pathway.
KW  - Biochemistry
KW  - enzymes
KW  - Human diseases
KW  - parasites
KW  - Transferases
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Hypoxanthine phosphoribosyl transferase
KW  - location
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877134&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Entamoeba histolytica extrachromosomal circular ribosomal DNA: analysis of clonal variation in a hypervariable region.
AU  - Bhattacharya, S.
AU  - Bhattacharya, A.
AU  - Diamond, L. S.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1992///
VL  - 74
IS  - 2
SP  - 200
EP  - 204
SN  - 0014-4894
AD  - Bhattacharya, S.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920877695.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Using a set of 4 DNA probes spanning the coding region and part of the flanking region of the E. histolytica ribosomal RNA genes, the DNA bands generated by EcoRI digestion of Entamoeba DNA was analysed. This analysis included 5 strains of E. histolytica, 4 of E. moshkovskii, and one strain each of E. invadens and E. terrapinae. No common bands were observed between E. histolytica and the other Entamoeba. Within E. histolytica, 2 bands were conserved in all strains and the others were polymorphic. Detailed analysis of DNA from independently isolated clones of the strain HM-1:IMSS of E. histolytica showed 2 bands to be highly polymorphic. Of these, the 4.4-kb band of clone 6 was further analyzed. Polymorphism in this band was even demonstrated in cells of the same clone. Restriction enzyme analysis of this DNA band from 2 clones of HM-1:IMSS showed that the polymorphism may be due to variable numbers of DraI repeat units present in this DNA stretch.
KW  - clonal variation
KW  - DNA probes
KW  - Human diseases
KW  - Molecular genetics
KW  - parasites
KW  - ribosomal DNA
KW  - Endamoebidae
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Endamoebidae
KW  - biochemical genetics
KW  - somatic variation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877695&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Entamoeba histolytica: is conversion of "nonpathogenic" amebae to the "pathogenic" form a real phenomenon?
AU  - Clark, C. G.
AU  - Cunnick, C. C.
AU  - Diamond, L. S.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1992///
VL  - 74
IS  - 3
SP  - 307
EP  - 314
SN  - 0014-4894
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878704.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Entamoeba histolytica isolates have been shown to fall into 2 groups based on isoenzyme analysis. These groupings ("pathogenic" and "nonpathogenic") correlate well with the clinical course of the infection. A controversy exists over whether isoenzyme patterns are stable or whether under certain circumstances an isolate can convert from one form to the other. Resolution of this uncertainty is of importance since the nonpathogenic pattern has never been observed in amoebae isolated from cases of active disease. This implies that, if the patterns are stable, carriers of amoebae with this nonpathogenic pattern may never develop invasive disease. In a study of isoenzyme conversion, the authors were unable to replicate the 2 published accounts of this phenomenon. They examined all of the variables proposed to be involved in the triggering of conversion, both individually and in combination. In none of the experiments was an alteration in the isoenzyme pattern observed. The authors believe that isoenzyme patterns are stable and that all available evidence, other than the reported conversions, points to pathogenic and nonpathogenic E. histolytica being distinct species.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;These authors had previously reported that pathogenic and nonpathogenic Entamoeba histolytica ribosomal RNA genes are distinct. Using that information they endeavoured by extensive experimentation to repeat the 2 single experiments (by different workers) that attempted to challenge zymodeme classification and stability. They now report on those 2 experiments as follows, "Although we cannot explain how Mirelman et al. [see Trop. Dis. Bull., 1987, 84, abst. 2685] and Andrews et al. [ibid., 1990, 87, abst. 2320] obtained their results, it is our opinion that they are artifactual. We now consider the pathogenic and nonpathogenic forms of Ent. histolytica as being distinct species."P.G. Sargeaunt
KW  - Chemotaxonomy
KW  - differentiation
KW  - Human diseases
KW  - Isoenzymes
KW  - parasites
KW  - pathogenicity
KW  - Endamoebidae
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Endamoebidae
KW  - biochemical taxonomy
KW  - isozymes
KW  - nonpathogenic
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878704&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of dietary fat on length of the follicular phase of the menstrual cycle in a controlled diet setting.
AU  - Reichman, M. E.
AU  - Judd, J. T.
AU  - Taylor, P. R.
AU  - Nair, P. P.
AU  - Jones, D. Y.
AU  - Campbell, W. S.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1992///
VL  - 74
IS  - 5
SP  - 1171
EP  - 1175
SN  - 0021-972X
AD  - Reichman, M. E.: National Cancer Institute, National Institutes of Health, EPN 211, Rockville, Maryland 20892, USA.
N1  - Accession Number: 19931468320.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - The length of the follicular phase of the menstrual cycle (defined as the time from the 1st day of menses until the day of urinary LH peak, inclusive) was examined in 30 healthy, premenopausal women 20-40 years old. Women consumed defined, weight maintaining diets, with a ratio of polyunsaturated to saturated fatty acids (P/S ratio) of 0.3 or 1.0. Both P/S groups consumed a high fat diet (40% energy from fat) for 4 menstrual cycles, followed by 4 menstrual cycles of a low fat diet (20% energy from fat). There was a significant increase (P&lt;0.006) in length of the follicular phase of the menstrual cycle during consumption of the low fat diet. Two thirds of women showed increases in follicular phase length with an average increase of 1.9 days.
KW  - fats
KW  - intake
KW  - menstrual cycle
KW  - Polyunsaturated fats
KW  - Saturated fats
KW  - Women
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - polyenoic fats
KW  - Physiology of Human Nutrition (VV120) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468320&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tyrosine kinase activity of skeletal muscle during insulin infusion in humans.
AU  - Nyomba, B. L.
AU  - Ossowski, V. M.
AU  - Saad, M. F.
AU  - Bogardus, C.
AU  - Mott, D. M.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1992///
VL  - 75
IS  - 1
SP  - 218
EP  - 223
SN  - 0021-972X
AD  - Nyomba, B. L.: Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19941402218.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 9004-10-8, 60-18-4.  Subject Subsets: Human Nutrition
N2  - The time course of the in vivo activation of tyrosine kinase was examined. 5 male nondiabetic Pima Indians (28±3 years old) had a euglycaemic clamp at an insulin dose of 600 mU min-1 m-1, resulting in plasma insulin values of about 15 nM by 30 min. Percutaneous muscle biopsies were taken from the vastus lateralis before and at regular intervals during insulin infusion and the in vivo and in vitro tyrosine kinase activities were measured. There was a rapid in vivo activation of the kinase, detectable at &lt;10 min and reaching a maximum within 30 min of insulin infusion. The time course of in vivo kinase activity, plasma insulin values and insulin-mediated glucose disposal rates displayed parallel patterns, indicating close interrelations among these variables. The insulin value at which the kinase activity was maximal was about 10 nM in vivo and in vitro. In vitro, however, this maximum increased with the degree of the kinase activation in vivo, indicating that the kinase potential in vitro is dependent on previous insulin exposure in vivo. It is concluded that in vivo activation of the insulin receptor tyrosine kinase in human skeletal muscle is a rapid process, related to insulin action on glucose disposal and that circulating insulin primes inactive insulin receptor molecules for subsequent tyrosine kinase activation by a mechanism that remains to be elucidated.
KW  - activity
KW  - ethnic groups
KW  - infusion
KW  - insulin
KW  - kinases
KW  - skeletal muscle
KW  - tyrosine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: antibodies to circumsporozoite protein prevent sporozoites from invading the salivary glands of Aedes aegypti.
AU  - Warburg, A.
AU  - Touray, M.
AU  - Krettli, A. U.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1992///
VL  - 75
IS  - 3
SP  - 303
EP  - 307
SN  - 0014-4894
AD  - Warburg, A.: Laboratory of Malaria Research, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920801479.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - A circumsporozoite protein-specific MAb (N2H6D5) was injected into malaria-infected mosquitoes to determine its effect on the sporogonic cycle. After injection of antibody into mosquitoes (100 ng each), positive immunofluorescence (measured on air-dried sporozoites) reactions in haemolymph extracts were observed at a dilution of 1:1000. At 72 h postinjection the levels dropped to 1:10. Sporozoites coinjected with antibody did not invade the salivary glands. In naturally infected mosquitoes, sporozoites were released over a period of 3 to 4 days. Therefore, mosquitoes were injected twice. The first injection was a day before the beginning of sporozoite release and the 2nd, 2 days later. Sporozoite invasion of the salivary glands was assessed 3 days after the 2nd injection, by microscopic examination of dissected glands. At this stage, all oocysts had completed maturation and released the sporozoites. Salivary gland infections were totally prevented in mosquitoes given 2 injections of 100 ng N2H6D5. Hence, sustained presence of anti-circumsporozoite antibodies in the haemolymph can render female Aedes aegypti refractory to P. gallinaceum.
KW  - Antibodies
KW  - Circumsporozoite protein
KW  - Disease vectors
KW  - infection
KW  - Monoclonal antibodies
KW  - parasites
KW  - resistance
KW  - Salivary glands
KW  - Sporozoites
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - Refractoriness
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801479&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.
AU  - Counts, D. R.
AU  - Gwirtsman, H.
AU  - Carlsson, L. M. S.
AU  - Lesem, M.
AU  - Cutler, G. B., Jr.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1992///
VL  - 75
IS  - 3
SP  - 762
EP  - 767
SN  - 0021-972X
AD  - Counts, D. R.: National Institutes of Health, Building 10, Room 10N262, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19931468056.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 61912-98-9, 9002-72-6.  Subject Subsets: Human Nutrition
N2  - The relation between serum insulin-like growth factor-I (IGF-I), IGF-II, the IGF-binding proteins IGFBP-I, IGFBP-2, and IGFBP-3, and GH-binding protein (GHBP) (which is postulated to be derived from the extracellular portion of the GH receptor) was examined in normal women and women with anorexia nervosa before and after a refeeding programme. Serum GHBP, IGF-I, and IGFBP-3 were significantly decreased in low weight patients with anorexia nervosa and returned to nearly normal values with refeeding. Fasting serum GH and serum IGFBP-1 and IGFBP-2 were significantly increased in low weight patients with anorexia nervosa and also returned to nearly normal values with refeeding. Serum IGF-II was 27% lower in the low weight group than in normal subjects, but this difference was not significant. Serum IGF-I and IGF-II were positively correlated with serum IGFBP-3 and negatively correlated with serum IGFBP-1 and IGFBP-2. Thus, it appears that nutritional deprivation alters the GH-IGF axis by down-regulation of the GH-receptor or its postreceptor mechanisms and that this effect is reversible with refeeding.
KW  - anorexia nervosa
KW  - binding proteins
KW  - blood
KW  - insulin-like growth factor
KW  - refeeding
KW  - somatotropin
KW  - Women
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - growth hormone
KW  - somatomedin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification and characterization of a Giardia lamblia group-specific gene.
AU  - Nash, T. E.
AU  - Mowatt, M. R.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1992///
VL  - 75
IS  - 4
SP  - 369
EP  - 378
SN  - 0014-4894
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930802456.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Giardia lamblia [G. duodenalis] consist of heterogeneous isolates that can be divided into at least 3 groups. Differential screening of a cDNA library with isolate-specific antisera identified a gene which is expressed and found only in Group 3 isolates. This gene, GLORF-C4, is 597 bp in length and predicts a deduced protein of 198 amino acids that is characterized by a polyserine motif. Giardia can also be grouped by their ability to express certain variant-specific surface proteins (VSPs), expression of which is restricted among groups. In Southern blots, probes specific to 2 VSPs were used to characterize isolates. Failure to detect VSP genes correlated with inability to express the same VSP. The groupings previously suggested using other criteria were confirmed.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors have sequenced a gene, GLORF-C4, that is found only in Group 3 Giardia lamblia, and have further characterized Giardia isolates by use of DNA probes specific to 2 variant-specific surface proteins, each uniquely expressed in Giardia Groups 1 and 2. Distinguishing features for the 3 groups are summarized.Carolyn A. Brown
KW  - Chemotaxonomy
KW  - COMPLEMENTARY DNA
KW  - DNA libraries
KW  - Genes
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - Proteins
KW  - Strain differences
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - biochemical taxonomy
KW  - cDNA
KW  - DNA sequences
KW  - Giardia lamblia
KW  - Group 3
KW  - variant specific surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802456&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a muscle-associated antigen from Wuchereria bancrofti.
AU  - Raghavan, N.
AU  - Maina, C. V.
AU  - Fitzgerald, P. C.
AU  - Tuan, R. S.
AU  - Slatko, B. E.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1992///
VL  - 75
IS  - 4
SP  - 379
EP  - 389
SN  - 0014-4894
AD  - Raghavan, N.: Laboratory of Parasitic Diseases, Building 4/Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930802457.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - A recombinant clone, WbN1, isolated from a genomic expression library of Wuchereria bancrofti and showing restricted specificity at the DNA level (Southern and PCR analyses) for W. bancrofti and Brugia malayi has been previously described. Sequence analysis of WbN1 indicated that it had notable similarity to myosin. Further characterization using in situ hybridization localized the mRNA in the muscle of the adult parasite and in the microfilariae. Rabbit polyclonal antiserum raised against the recombinant WbN1 fused to the maltose-binding protein, recognized a 200 000 MW polypeptide in immunoblots containing B. malayi antigen extracts. The same antibody also recognized myosin extracted from B. pahangi, Onchocerca volvulus and Caenorhabditis elegans. Localization using the rabbit antiserum revealed the presence of the antigen in adult muscle tissue and microfilariae; the same antibody inhibited the binding of a MAb 28.2 (directed toward MHC B of C. elegans myosin) to the recombinant WbN1 antigen and also to purified C. elegans myosin. Based on homology data, structural location, competitive ELISA, and immunoblot it is concluded that WbN1 is related to myosin or a similar myofibrillar protein.
KW  - antigens
KW  - helminths
KW  - Messenger RNA
KW  - Monoclonal antibodies
KW  - muscles
KW  - MYOSINS
KW  - parasites
KW  - Proteins
KW  - Recombinant proteins
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Wuchereria
KW  - Onchocercidae
KW  - antigenicity
KW  - immunogens
KW  - mRNA
KW  - myosin
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802457&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol intake in relation to lipids, lipoproteins and blood pressure.
AU  - Rossouw, J. E.
AU  - Tung, M. T. L.
AU  - Jooste, P. L.
AU  - Weight, M. J.
AU  - Benadé, A. J. S.
JO  - South African Medical Journal
JF  - South African Medical Journal
Y1  - 1992///
VL  - 82
IS  - 4
SP  - 246
EP  - 250
SN  - 0038-2469
AD  - Rossouw, J. E.: Lipid Metabolism Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19941403766.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - 655 men and 731 women were studied to evaluate the association between alcohol intake, HDL cholesterol (HDL-C) and its subfractions and blood pressure in different age groups (20-44 and 45-64 years old). Habitual alcohol intake was significantly related to higher HDL-C values in men and women. In men HDL2-C and HDL3-C were increased, while in women this increase was restricted almost entirely to HDL2-C. Plasma apolipoprotein A-I and A-II were elevated in men who consumed alcohol but not in women. In men and women, triacylglycerols and blood pressure were increased with habitual alcohol intake and the increases in HDL subfractions and blood pressure became more marked with increasing age in both sexes. Recent alcohol intake had less effect on all variables except blood pressure. It is concluded that HDL3-C and HDL2-C contribute to the increase in HDL-C that accompanies alcohol intake, notwithstanding differences in responses of sexes. A regular alcohol intake is more likely to be beneficial and some of the positive or protective aspects of alcohol consumption could be reduced by adverse changes in triacylglycerol and blood pressure.
KW  - age
KW  - alcoholic beverages
KW  - blood
KW  - blood lipids
KW  - blood pressure
KW  - intake
KW  - lipoproteins
KW  - sex differences
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403766&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sources of fiber and fat in diets of US women aged 19 to 50: implications for nutrition education and policy.
AU  - Thompson, F. E.
AU  - Sowers, M. F.
AU  - Frongillo, E. A.
AU  - Parpia, B. J.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992///
VL  - 82
IS  - 5
SP  - 695
EP  - 702
SN  - 0090-0036
AD  - Thompson, F. E.: Applied Research Branch, National Cancer Institute, Executive Plaza North, Room 330, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931458511.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
N2  - Contributions of 27 food groups to fibre, fat, saturated fat, and cholesterol intakes of 2134 women (19 to 50 years old) in USDA's Continuing Survey of Food Intakes by Individuals, the 1985 and 1986 surveys were analysed. Major determinants of fibre intake included frequency of use of certain food groups (vegetables, including potato, bread, fruit, soups, ready-to-eat cereal) and choice of particular foods within the larger food groups (e.g., whole grain bread, high fibre cereal). Major determinants of total fat, saturated fat, and cholesterol intakes included frequency of use of certain foods (sweet grains, beef, eggs, cheeses/cream, whole milks) and additions to foods (regular salad dressing and butter or margarine). Demographic characteristics were related to various food group consumption parameters. It is concluded that the relation between food group and nutrient intake and effects of household income, ethnicity, and region of residence on food group intake indicate opportunities to refine nutritional education programmes.
KW  - diet studies
KW  - fats
KW  - fibre
KW  - intake
KW  - Nutrition education
KW  - Nutrition programmes
KW  - sources
KW  - Women
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - feeding programmes
KW  - feeding programs
KW  - fiber
KW  - food programs
KW  - nutrition programs
KW  - United States of America
KW  - Animal Nutrition (Production Responses) (LL520) 
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931458511&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current serum levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in phenoxy acid herbicide applicators and characterization of historical levels.
AU  - Johnson, E. S.
AU  - Parsons, W.
AU  - Weinberg, C. R.
AU  - Shore, D. L.
AU  - Mathews, J.
AU  - Patterson, D. G., Jr.
AU  - Needham, L. L.
JO  - Journal of the National Cancer Institute.
JF  - Journal of the National Cancer Institute.
Y1  - 1992///
VL  - 84
IS  - 21
SP  - 1648
EP  - 1652
AD  - Johnson, E. S.: Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 19932331693.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 25168-15-4, 2545-59-7, 3813-14-7, 57213-69-1, 7173-98-0, 93-76-5, 93-79-8, 94-75-7, 94-80-4, 2008-39-1, 1929-73-3.  Subject Subsets: Weeds
N2  - In studies of Australian workers occupationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in preparations of 2,4,5-T and 2,4-D, serum was analysed by GC and MS to compare levels of TCDD in those workers exposed before 1965 (when concn in herbicides were unregulated and high) with those exposed after 1974 (when concn were lower due to government regulations). Mean exposure rates to TCDD were 2.7, 2.3 and 0.06 parts per trillion per month for the periods before 1965, 1965-1975 and 1975-1991, resp. The highest estimated dose was 20.7 parts per trillion, which suggested that some workers may have been exposed to levels comparable to those that produce cancer in laboratory animals.
KW  - 2,4,5-T
KW  - 2,4-D
KW  - application
KW  - chemistry
KW  - herbicide impurities
KW  - Herbicides
KW  - laboratory animals
KW  - safety
KW  - toxicology
KW  - Australia
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - (2,4,5-trichlorophenoxy)acetic acid
KW  - (2,4-dichlorophenoxy)acetic acid
KW  - weedicides
KW  - weedkillers
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pest and Weed Control Equipment (NN430) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932331693&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant Pfs25.
AU  - Kaslow, D. C.
AU  - Bathurst, I. C.
AU  - Isaacs, S. N.
AU  - Keister, D. B.
AU  - Moss, B.
AU  - Barr, P. J.
A2  - Ribeiro, C. T. D.
A2  - Momen, H.
JO  - Memórias do Instituto Oswaldo Cruz
JF  - Memórias do Instituto Oswaldo Cruz
Y1  - 1992///
VL  - 87
IS  - Suppl. III
SP  - 175
EP  - 177
SN  - 0074-0276
AD  - Kaslow, D. C.: National Institute of Allergy and Infectious Diseases, Malaria Section, Laboratory of Parasitic Diseases, Building 4, Room B1-37, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805289.  Publication Type: Journal Article.  Language: English. 
N2  - The induction of Plasmodium falciparum transmission blocking antibodies by rPfs25, a cysteine-rich 25 000 MW glycolipoprotein expressed predominately in zygotes and ookinetes, is reviewed.
KW  - transmission blocking antibodies
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805289&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - National cholesterol education program (NCEP): highlights of the report of the expert panel on blood cholesterol levels in children and adolescents.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1992///
VL  - 89
IS  - 3
SP  - 495
EP  - 500
SN  - 0031-4005
AD  - NCEP, National Heart, Lung, and Blood Institute, Bldg 31, Room 4A05, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921452801.  Publication Type: Journal Article.  Corporate Author: USA, NCEP expert panel on blood cholesterol levels in children and adolescents Language: English.  Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The significance of blood cholesterol levels in childhood and adolescence is reviewed by a panel of experts. The report is published as a supplement to this issue of the journal. Highlights of the report are presented.
KW  - Adolescents
KW  - blood
KW  - Children
KW  - cholesterol
KW  - heart diseases
KW  - reviews
KW  - risk
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - coronary diseases
KW  - teenagers
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921452801&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.
AU  - Kopp, J. B.
AU  - Klotman, M. E.
AU  - Adler, S. H.
AU  - Bruggeman, L. A.
AU  - Dickie, P.
AU  - Marinos, N. J.
AU  - Eckhaus, M.
AU  - Bryant, J. L.
AU  - Notkins, A. L.
AU  - Klotman, P. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1992///
VL  - 89
IS  - 5
SP  - 1577
EP  - 1581
SN  - 0027-8424
AD  - Kopp, J. B.: Laboratory of Developmental Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920194922.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2  - By using a non-infectious human immunodeficiency-virus type 1 (HIV-1) DNA construct lacking the gag and pol genes, 3 transgenic mouse lines have been generated that develop a syndrome similar to the human disease. In this study, one of these lines, Tg26 was studied in detail. In Tg26 mice, proteinuria was detectable at approx. 24 days of age, followed by severe nephrotic syndrome and rapid progression to end-stage renal failure. Renal histology showed focal segmental glomerulosclerosis and microcystic tubular dilatation. Indirect immunofluorescence studies demonstrated increased accumulation of the basement membrane components laminin, collagen type IV and heparan sulphate proteoglycan. The viral protein Rev was present in sclerotic glomeruli. Northern blot analysis of total renal RNA showed expression of viral genes prior to the appearance of histological renal disease, with greatly diminished viral gene expression late in the disease course. Kidneys from transgenic mice expressed increased steady-state levels of collagen α1(IV) mRNA when glomerulosclerosis was present. It is concluded that the presence of HIV-1 genes is associated with progressive renal dysfunction and glomerulosclerosis in transgenic mice.
KW  - Animal models
KW  - Biotechnology
KW  - damage
KW  - gene expression
KW  - Gene transfer
KW  - Genetic engineering
KW  - genetically engineered organisms
KW  - human immunodeficiency viruses
KW  - kidneys
KW  - Pathology
KW  - renal failure
KW  - transgenic animals
KW  - transgenics
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - genetic manipulation
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - Glomeruli
KW  - GMOs
KW  - Human immunodeficiency virus
KW  - kidney failure
KW  - Murine
KW  - transgenic mice
KW  - transgenic organisms
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920194922&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses.
AU  - Pletnev, A. G.
AU  - Bray, M.
AU  - Huggins, J.
AU  - Lai ChingJuh
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1992///
VL  - 89
IS  - 21
SP  - 10532
EP  - 10536
SN  - 0027-8424
AD  - Pletnev, A. G.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930518258.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - Dengue type 4 virus (DEN4) cDNA was used as a vector to express genes of the distantly related tick-borne encephalitis virus (TBEV). Full-length chimaeric TBEV/DEN4 cDNAs were constructed by substituting TBEV genes coding for proteins such as capsid (C); pre-membrane, which is the precursor of membrane (M); envelope (E); or nonstructural protein NS1 for the corresponding DEN4 sequences. RNA transcripts prepared from cDNAs were used to transfect permissive simian cells. 2 viable chimaeric viruses that contained TBEV CME or ME genes were recovered. Compared with DEN4, chimaeric TBE(ME)/DEN4 virus (designated vTBE(ME)/DEN4) produced larger plaques and grew to higher titre in simian cells. In contrast, vTBE(ME)/DEN4 produced smaller plaques on Aedes albopictus C6/36 mosquito cells and grew to lower titre than DEN4. Analysis of viral RNA and proteins produced in vTBE(ME)/DEN4- and DEN4-infected mosquito or simian cells revealed that the chimaera was restricted in its ability to enter and replicate in mosquito cells. In contrast, vTBE(ME)/DEN4 entered simian cells efficiently and its RNA was replicated more rapidly in these cells than was parental DEN4 RNA. Following intracerebral inoculation, vTBE(ME)/DEN4 caused fatal encephalitis in both suckling and adult mice, while nearly all mice inoculated by the same route with DEN4 did not develop disease. Unlike wild-type TBEV, vTBE(ME)/DEN4 did not cause encephalitis when adult mice were inoculated by a peripheral route. Adult mice previously inoculated with the chimaera by a peripheral route were completely resistant to subsequent intraperitoneal challenge with 10³ times the median lethal dose of TBEV, whereas mice previously inoculated with DEN4 were not protected. These findings indicate that the TBEV M and E genes of the chimaeric virus are major protective antigens and induce resistance to lethal TBEV challenge, and that other regions of the TBEV genome are essential for the ability of this virus to spread from a peripheral site to the brain. Success in constructing a viable TBEV/DEN4 chimaera that retains the protective antigens of TBEV but lacks its peripheral invasiveness provides a strategy for the development of live attenuated TBEV vaccines.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Dengue type 4 virus (DEN4) cDNA was used as a vector to express genes of the distantly related tick-borne encephalitis virus (TBEV). Full-length chimeric TBEV/DEN4 cDNA were constructed by substituting TBEV genes coding for proteins such as capsid (C); pre-membrane, which is the precursor of membrane (M); envelope (E); or nonstructural protein NS1 for the corresponding DEN4 sequences. RNA transcripts prepared from cDNAs were used to transfect permissive simian cells. Two viable chimeric viruses that contained TBEV CME or ME genes were recovered. Compared with DEN4, chimeric TBE(ME)/DEN4 virus [designated vTBE(ME)/DEN4] produced larger plaques and grew to higher titer in simian cells. In contrast, vTBE(ME)/DEN4 produced smaller plaques on mosquito cells and grew to lower titer than DEN4. Analysis of viral RNA and proteins produced in vTBE(ME)/DEN4- and DEN4-infected mosquito or simian cells revealed that the chimera was restricted in its ability to enter and replicate in mosquito cells. In contrast, vTBE(ME)/DEN4 entered simian cells efficiently and its RNA was replicated more rapidly in these cells than was parental DEN4 RNA. Following intracerebral inoculation, vTBE(ME)/DEN4 caused fatal encephalitis in both suckling and adult mice, while nearly all mice inoculated by the same route with DEN4 did not develop disease. Unlike wild-type TBEV, vTBE(ME)/DEN4 did not cause encephalitis when adult mice were inoculated by a peripheral route. Adult mice previously inoculated with the chimera by a peripheral route were completely resistant to subsequent intraperitoneal challenge with 10³ times the median lethal dose of TBEV, whereas mice previously inoculated with DEN4 were not protected. These findings indicate that (i) the TBEV M and E genes of the chimeric virus are major protective antigens and induce resistance to lethal TBEV challenge and (ii) other regions of the TBEV genome are essential for the ability of this virus to spread from a peripheral site to the brain. Success in constructing a viable TBEV/DEN4 chimera that retains the protective antigens of TBEV but lacks its peripheral invasiveness provides a strategy for the development of live attenuated TBEV vaccines.AS
KW  - arboviruses
KW  - cell lines
KW  - chimaeras
KW  - gene expression
KW  - genetic engineering
KW  - vaccines
KW  - viral diseases
KW  - viral proteins
KW  - Aedes albopictus
KW  - Culicidae
KW  - dengue 4 virus
KW  - dengue virus
KW  - Flavivirus
KW  - mice
KW  - Tick-borne encephalitis virus
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - arthropod-borne viruses
KW  - Asian tiger mosquito
KW  - Central European encephalitis virus
KW  - chimeras
KW  - genetic manipulation
KW  - mosquitoes
KW  - neurovirulence
KW  - tickborne encephalitis virus
KW  - viral infections
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518258&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lower sedentary metabolic rate in women compared with men.
AU  - Ferraro, R.
AU  - Lillioja, S.
AU  - Fontvieille, A. M.
AU  - Rising, R.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1992///
VL  - 90
IS  - 3
SP  - 780
EP  - 784
SN  - 0021-9738
AD  - Ferraro, R.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N. 16th Street, Room 541, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19941402319.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
N2  - 24-h energy expenditure (24EE), basal metabolic rate (BMR) and sleeping metabolic rate (SMR) were measured in a respiratory chamber in healthy, nondiabetic Caucasian subjects (114 males, 34±14 years old; 121 females, 38±17 years old). Body composition was estimated by hydrodensitometry. 24EE was 124±38 kcal/day (P&lt;0.002) higher in males than females after adjusting for differences in fat-free mass, fat mass and age. Spontaneous physical activity was not significantly different between males and females. Since adjusted 24EE was 106±39 kcal/day (P&lt;0.01) higher in females during the luteal phase of the menstrual cycle compared with females during the follicular phase, energy expenditure was analysed in subjects &gt;50 years old to minimize the confounding effect of menstrual status. 24EE (160±66; P&lt;0.03), BMR (116±45; P&lt;0.02), and SMR (208±68 kcal/day; P&lt;0.005) were higher in males compared with females &gt;50 years old after adjusting for differences in body composition, age and activity. It is indicated that sedentary 24EE is about 5-10% lower in females compared with males after adjusting for differences in body composition, age and activity.
KW  - body composition
KW  - comparisons
KW  - energy exchange
KW  - men
KW  - metabolism
KW  - obesity
KW  - resting energy exchange
KW  - sex differences
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402319&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoid protection against X-ray-induced chromatid damage in human peripheral blood lymphocytes.
AU  - Sanford, K. K.
AU  - Parshad, R.
AU  - Price, F. M.
AU  - Tarone, R. E.
AU  - Kraemer, K. H.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1992///
VL  - 90
IS  - 5
SP  - 2069
EP  - 2074
SN  - 0021-9738
AD  - Sanford, K. K.: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19931462115.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Human Nutrition
N2  - X-ray induced chromatid damage in phytohaemagglutinin-stimulated blood lymphocytes from 5 xeroderma pigmentosa (XP) patients receiving isotretinoin was about half that in blood samples from the same patients before and subsequent to treatment. The X-ray induced chromatid damage in blood lymphocytes from a normal control was reduced significantly by cocultivation with blood plasma from an XP patient receiving isotretinoin or by addition of 10-6M isotretinoin to cultures 1 h before X-irradiation. A similar reduction in X-ray-induced chromatic damage was reported previously by adding to the culture medium mannitol, a scavenger of the free hydroxyl radical, or catalase, which decomposes hydrogen peroxide. Both of these products are generated during ionizing radiation. These observations suggest that isotretinoin acts as a scavenger of such radiation products, thereby providing protection against X-ray induced chromatic damage.
KW  - chromatids
KW  - Free radicals
KW  - lymphocytes
KW  - radiation protection
KW  - retinoids
KW  - Skin diseases
KW  - X radiation
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dermatoses
KW  - vitamin A compounds
KW  - X rays
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Community-based evaluation of the effect of breast-feeding on the risk of microbiologically confirmed or clinically presumptive shigellosis in Bangladeshi children.
AU  - Ahmed, F.
AU  - Clemens, J. D.
AU  - Rao, M. R.
AU  - Sack, D. A.
AU  - Khan, M. R.
AU  - Haque, E.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1992///
VL  - 90
IS  - 3 Part 1
SP  - 406
EP  - 411
SN  - 0031-4005
AD  - Ahmed, F.: (J. D. Clemens), Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Plaza Building, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020252.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - To assess the association between breast-feeding and the risk of microbiologically confirmed or clinically presumptive shigellosis, the authors performed a case-control analysis of Bangladeshi children younger than 3 years of age who were followed up for 1 month after exposure to Shigella in their residential neighborhoods. Two hundred sixty-nine cases with culture-confirmed shigellosis (n = 119) or clinically presumptive shigellosis (culture-negative dysentery, n = 150) were compared with 819 controls without Shigella diarrhea or other invasive diarrheal illnesses. The odds ratio relating breast-feeding to confirmed or presumptive shigellosis, adjusted for potentially confounding variables, was 0.48 (95% confidence interval = 0.32 to 0.72; P &lt;0.001), suggesting a substantial protective effect. The protective association decreased with age but was still significant during the third year of life; appeared to be directly related to the degree of stunting; and was equivalent for confirmed and presumptive shigellosis. Notably, the protective association remained substantial against episodes due to Shigella which were resistant to at least one of the antibiotics customarily used for treatment of Shigella diarrhea (age-adjusted odds ratio = 0.40; 95% confidence interval = 0.22 to 0.74; P &lt;0.01). These data suggest that breast-feeding confers a high level of protection against shigellosis throughout the first 3 years of life, especially among nutritionally compromised children, and thereby underscore the importance of promotion of breast-feeding as a central component of Shigella control programs in less developed settings. AS
KW  - breast
KW  - breast feeding
KW  - children
KW  - feeding
KW  - infants
KW  - shigellosis
KW  - Asia
KW  - Bangladesh
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - breasts
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020252&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food sources of energy, macronutrients, cholesterol, and fiber in diets of women.
AU  - Krebs-Smith, S. M.
AU  - Cronin, F. J.
AU  - Haytowitz, D. B.
AU  - Cook, D. A.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1992///
VL  - 92
IS  - 2
SP  - 168
EP  - 174
SN  - 0002-8223
AD  - Krebs-Smith, S. M.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931459752.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Human Nutrition; Potatoes
N2  - Data from the 1985 Continuing Survey of Food Intakes by Individuals in the USA were used to calculate the contributions of individual foods to women's intakes of energy, protein, carbohydrate, fat, saturated fatty acids, cholesterol and fibre. Nearly all food mixtures were separated into their constituent ingredients, the ingredients were grouped with similar foods, and the contributions of those foods were examined. Yeast breads that were neither whole-grain nor higher-fibre contributed about 7% of the energy to the diets, which made them the leading source of energy of the foods examined. The leading sources of protein were animal products: poultry contributed about 12%, beef about 19%, cheese about 8% and pork about 6%. The various fats and oils were the greatest contributors to fat, and cheese was the chief source of saturated fatty acids. Eggs were the major source of cholesterol, providing around 36% of the total. Two of the top 3 sources of carbohydrate, regular soft drinks and sugar, are composed entirely of simple sugars. Potatoes provided around 11% of the fibre, which made them the leading source of fibre. The relative ranking of foods and the contribution of each food depend on the way food codes are combined. Therefore, citing one food as the major source of a particular food component without including documentation of how foods are combined can be misleading.
KW  - fibre
KW  - intake
KW  - nutrients
KW  - Nutrition
KW  - sources
KW  - Women
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fiber
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459752&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparative evaluation of fibric acid derivatives and HMG-CoA reductase inhibitors.
AU  - Brewer, H. B.
JO  - Atherosclerosis
JF  - Atherosclerosis
Y1  - 1992///
VL  - 97
IS  - Suppl.
SP  - S11
EP  - S19
SN  - 0021-9150
AD  - Brewer, H. B.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19931463042.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 9004-02-8, 503-49-1.  Subject Subsets: Human Nutrition
N2  - A review. Fibric acid derivatives (fibrates) and β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are hyperlipaemic agents with contrasting mechanisms of action. By increasing the activity of lipoprotein lipase, fibrates exert a pronounced triacylglycerol-lowering effect, which, however, varies with the nature of the underlying lipid abnormality. Reductase inhibitors are the most potent cholesterol-lowering drugs available. By inhibiting HMG-CoA reductase these agents induce a compensatory increase in the synthesis and expression of hepatic low density lipoprotein (LDL) receptors, resulting in reduction of plasma LDL. There is also evidence that reductase inhibitors inhibit the synthesis of LDL and apolipoprotein B. This action may be especially beneficial in patients with combined hyperlipaemia with overproduction of LDL and apo B. Reductase inhibitors also reduce triacylglycerol values, but to a lesser extent than LDL, and this effect is not as marked as that of fibrates. LDL is regarded as the principal atherogenic lipoprotein and preference may therefore be given to reductase inhibitors in lipid regulation for prevention of coronary heart disease. Fibrates, however, offer advantages in the management of patients with predominant or exclusive hypertriglyceridaemia.
KW  - drug therapy
KW  - Enzyme inhibitors
KW  - Hypercholesterolaemia
KW  - Hyperlipaemia
KW  - Hypertriglyceridaemia
KW  - Lipoprotein lipase
KW  - meglutol
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 3-hydroxy-3-methylglutaric acid
KW  - chemotherapy
KW  - diacylglycerol lipase
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - hyperlipemia
KW  - hypertriglyceridemia
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931463042&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Binding of tricyclic antidepressant drugs to trophozoites of Giardia lamblia.
AU  - Weinbach, E. C.
AU  - Levenbook, L.
AU  - Alling, D. W.
JO  - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
JF  - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
Y1  - 1992///
VL  - 102
IS  - 3
SP  - 391
EP  - 396
SN  - 0306-4492
AD  - Weinbach, E. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930802520.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology
N2  - Parameters affecting the binding of the tricyclic drugs imipramine and 3-chlorimipramine to G. lamblia [G. duodenalis] trophozoites (Portland 1 strain, ATCC 3088) were studied. Two to 3 times more chlorimipramine than imipramine was bound, consistent with a similar difference in suppressing parasite growth. Kinetic analysis and the ease with which bound drugs can be washed out of the parasites is thought to indicate that noncovalent forces are involved in the drug-parasite interaction. Evidence is presented that such drugs probably bind to parasite protein at common binding sites. The data relate to an earlier observation that chlorimipramine is about 10 times more effective than metronidazole in suppressing G. lamblia growth in vitro. It is thought that tricyclic drugs, therefore, merit serious consideration as novel therapeutic agents against giardiasis.
KW  - Antidepressants
KW  - Antiprotozoal agents
KW  - Developmental stages
KW  - in vitro
KW  - mode of action
KW  - parasites
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - 3-chlorimipramine
KW  - growth phase
KW  - imipramine
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduction of pulmonary surfactant in patients with human immunodeficiency virus infection and Pneumocystis carinii pneumonia.
AU  - Hoffman, A. G. D.
AU  - Lawrence, M. G.
AU  - Ognibene, F. P.
AU  - Suffredini, A. F.
AU  - Lipschik, G. Y.
AU  - Kovacs, J. A.
AU  - Masur, H.
AU  - Shelhamer, J. H.
JO  - Chest
JF  - Chest
Y1  - 1992///
VL  - 102
IS  - 6
SP  - 1730
EP  - 1736
SN  - 0012-3692
AD  - Hoffman, A. G. D.: Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19930883396.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Protozoology
N2  - Both qualitative and quantitative differences in surfactant lipid composition of bronchoalveolar lavage (BAL) fluid in patients with AIDS and Pneumocystis carinii pneumonia (PCP) were assessed. BAL was carried out on 5 normal volunteers and 27 patients in the National Institutes of Health, Maryland, USA, with HIV infection. BAL studies were positive for P. carinii in 19 patients. Total lipid profiles of dephosphorylated glycerolipids were analyzed by high temperature gas-liquid chromatography. Phospholipase A2 levels were determined using a radiolabelled E. coli method. Compared to the normal volunteers and the P. carinii negative patients, total BAL lipid was reduced in patients with PCP. There was a parallel reduction for diacylglycerol lipids. Phospholipase A2 activity in moderate to severe PCP patients was twice that of the P. carinii negative patients, and 30 times that for normal volunteers. The data demonstrate a marked diminution in surfactant glycerophospholipids in patients with AIDS and PCP and suggest a potential role for surfactant abnormality in the pathophysiology of this disease.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - bronchoalveolar lavage
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pathology
KW  - pneumonia
KW  - respiratory diseases
KW  - surfactants
KW  - Maryland
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - glyceropholipids
KW  - human immunodeficiency virus
KW  - lung diseases
KW  - surface active agents
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Measurements of iron status in patients with chronic hepatitis.
AU  - Bisceglie, A. M. di
AU  - Axiotis, C. A.
AU  - Hoofnagle, J. H.
AU  - Bacon, B. R.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1992///
VL  - 102
IS  - 6
SP  - 2108
EP  - 2113
SN  - 0016-5085
AD  - Bisceglie, A. M. di: Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19941403979.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 7439-89-6.  Subject Subsets: Human Nutrition
N2  - Patients with chronic viral hepatitis (67 men, 13 women; 94% of patients were white) were screened for evidence of iron overload. Elevated serum Fe values were noted in 36% of cases; serum ferritin values were above normal in 30% of men and 8% of women. Additional patients with chronic hepatitis (22 men, 6 women; 86% of patients were white) for whom liver tissue was available for estimation of Fe content were evaluated to study the significance of Fe overload in association with chronic hepatitis. Although 46% had elevated serum Fe, ferritin or transferrin-saturation levels, hepatic Fe concentration was elevated in only 4 cases and the hepatic Fe index was in the range for hereditary haemochromatosis (&gt;2.0) in only 2 of these. Serum aspartate aminotransferase activities correlated with serum ferritin levels in these patients, suggesting that ferritin and Fe levels were increased in serum because of their release from hepatocellular stores associated with necrosis. Thus, in patients with chronic hepatitis in whom hereditary haemochromatosis is suspected, a liver biopsy should be performed with quantitation of hepatic Fe and calculation of hepatic Fe index to confirm the diagnosis.
KW  - haemochromatosis
KW  - hepatitis
KW  - iron
KW  - liver
KW  - mineral metabolism disorders
KW  - nutritional state
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hemochromatosis
KW  - iron storage disease
KW  - nutritional status
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila.
AU  - Shinohara, T.
AU  - Kikuchi, T.
AU  - Tsuda, M.
AU  - Yamaki, K.
JO  - Comparative Biochemistry and Physiology. B, Comparative Biochemistry
JF  - Comparative Biochemistry and Physiology. B, Comparative Biochemistry
Y1  - 1992///
VL  - 103
IS  - 3
SP  - 505
EP  - 509
AD  - Shinohara, T.: Molecular Biology Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930518476.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
KW  - agricultural entomology
KW  - animal physiology
KW  - antigens
KW  - biochemistry
KW  - genes
KW  - genetics
KW  - molecular genetics
KW  - photoreceptors
KW  - reviews
KW  - vision
KW  - arthropods
KW  - cattle
KW  - Diptera
KW  - Drosophila
KW  - Drosophilidae
KW  - insects
KW  - man
KW  - mice
KW  - rats
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - Drosophilidae
KW  - Diptera
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Muridae
KW  - rodents
KW  - antigenicity
KW  - arrestins
KW  - biochemical genetics
KW  - immunogens
KW  - sight
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection and disease in lymphatic filariasis: an immunological perspective.
AU  - Ottesen, E. A.
JO  - Parasitology
JF  - Parasitology
Y1  - 1992///
VL  - 104
IS  - Suppl.
SP  - S71
EP  - S79
SN  - 0031-1820
AD  - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930878442.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 36 ref. Subject Subsets: Helminthology
N2  - The basic tenet of the immunological perspective of filarial disease is that differential immune responsiveness among individuals exposed to infection results in the different clinical manifestations that develop. The mechanisms involved in this differential responsiveness appear to reflect different T-cell cytokine response patterns. Asymptomatic patients with the clinically silent presentation of 'asymptomatic microfilaraemia', who have been previously described as being 'immunosuppressed' with respect to their generating pro-inflammatory (Th1-type) immune responses to parasite antigen, are now recognized to be fully responsive to parasite antigen but to produce cytokines and mediators that have primarily anti-inflammatory (Th2-like) effects. Studies with immunodeficient mice have indicated the existence of 2 alternative pathways to the development of lymphatic pathology: one dependent on the induction of inflammatory reactions by the host immune response, the other entirely independent of the immune system and reflecting the direct actions of the parasite or its products on the lymphatics. As histopathology of affected human lymphatics is consistent with this hypothesis, it may be that the lymphatic pathology seen normally in the amicrofilaraemic, highly immunoresponsive infected patients derives from inflammation induced by immune responses to parasite antigen, whereas the lymphatic pathology sometimes seen coexisting with the 'immunosuppressed' state of asymptomatic microfilaraemia actually reflects lymphatic damage that is not immunologically mediated. Though little information exists about the 'natural history' of lymphatic filariasis, there is no evidence for an inevitable progression from one clinical form to another. Instead, there appears to be a definite plasticity in the response that depends on prior (? pre-natal) and current exposure to the parasite as well as on the immunodulatory effects it induces. This plasticity does not appear to be complete, however, as there is no evidence that a chronically infected host who has developed strong pro-inflammatory immune responses can subsequently become sufficiently 'down-regulatory' to support an asymptomatic microfilaraemia type of infection. Another possible constraint to the plasticity of the clinical and immunological responses may be the genetic determination of certain unusual syndromes, such as tropical pulmonary eosinophilia or TPE, though this hypothesis remains to be proven.
KW  - Filariasis
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - immunology
KW  - Lymphatic filariasis
KW  - parasites
KW  - reviews
KW  - Brugia malayi
KW  - Brugia timori
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Wuchereria
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - GEN
T1  - Orally administered 566C80 for treatment of ocular toxoplasmosis in a patient with the acquired immunodeficiency syndrome.
AU  - Lopez, J. S.
AU  - Smet, M. D. de
AU  - Masur, H.
AU  - Mueller, B. U.
AU  - Pizzo, P. A.
AU  - Nussenblatt, R. B.
T2  - American Journal of Ophthalmology
JO  - American Journal of Ophthalmology
JF  - American Journal of Ophthalmology
Y1  - 1992///
VL  - 113
IS  - 3
SP  - 331
EP  - 333
SN  - 0002-9394
AD  - Lopez, J. S.: National Eye Institute, Bldg. 10, Rm. 10N226, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920800982.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Registry Number: 95233-18-4.  Subject Subsets: Protozoology
N2  - A 14-year-old haemophiliac boy with AIDS developed Toxoplasma gondii-induced retinochoroiditis in his right eye. The disease progressed despite pyrimethamine treatment (50 mg twice daily). Sulfadiazine and clindamycin were also given but were discontinued after causing allergic rashes. When the patient was referred to the National Institutes of Health, Maryland, USA, his visual acuity was 20/200 in his right eye. Ocular examination disclosed a localized area of vitritis over an ill-defined, superotemporal retinochoroidal infiltrate in the right eye. This lesion was adjacent to an old retinochoroidal scar and extended to the superior border of the disc with surrounding retinal oedema and a macular star. Anti-Toxoplasma IgG titre was 4.29 by ELISA. 566C80 was administered orally at a dose of 750 mg 4 times daily. On the 4th day of therapy, there was a significant resolution of the vitreal inflammation, which resulted in a clearer delineation of the macular star and adjacent subretinal haemorrhage. By 4 weeks, visual acuity improved to 20/40. There was no sign of recurrence at the 5-month follow-up and no adverse reactions to 566C80 were recognized.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Antiprotozoal agents
KW  - atovaquone
KW  - Children
KW  - drug therapy
KW  - Eyes
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - Toxoplasmosis
KW  - Maryland
KW  - North America
KW  - USA
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Combined use of cyclosporine and ketoconazole in the treatment of endogenous uveitis.
AU  - Smet, M. D. de
AU  - Rubin, B. I.
AU  - Whitcup, S. M.
AU  - Lopez, J. S.
AU  - Austin, H. A.
AU  - Nussenblatt, R. B.
JO  - American Journal of Ophthalmology
JF  - American Journal of Ophthalmology
Y1  - 1992///
VL  - 113
IS  - 6
SP  - 687
EP  - 690
SN  - 0002-9394
AD  - Smet, M. D. de: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931213731.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 79217-60-0, 65277-42-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - Patients (n=10) with endogenous uveitis were in clinical remission attributable to treatment with cyclosporin and prednisone. After the cyclosporin dose was reduced by two-thirds, these patients were randomly assigned to treatment with or without ketoconazole, a potent inhibitor of cytochrome P-450, in a double-masked placebo-controlled study. The dose was reduced over 3 d. During a 3-month follow-up, no patients treated with ketoconazole had a relapse of uveitis, while 4 of 6 (66%) control subjects had a flare-up. Toxicity in the ketoconazole-treated group was limited to a transient decrease in glomerular filtration rate (20% from baseline) at 1 month in 2 of 6 (33%) patients. Renal function was stabilized by further reduction of the cyclosporin dose.
KW  - antagonism
KW  - Antifungal agents
KW  - cyclosporins
KW  - Ketoconazole
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An unusually high prevalence of ocular toxoplasmosis in Southern Brazil.
AU  - Glasner, P. D.
AU  - Silveira, C.
AU  - Kruszon-Moran, D.
AU  - Martins, M. C.
AU  - Burnier, M, Jr.
AU  - Silveira, S.
AU  - Camargo, M. E.
AU  - Nussenblatt, R. B.
AU  - Kaslow, R. A.
AU  - Belfort, R, Jr.
JO  - American Journal of Ophthalmology
JF  - American Journal of Ophthalmology
Y1  - 1992///
VL  - 114
IS  - 2
SP  - 136
EP  - 144
SN  - 0002-9394
AD  - Glasner, P. D.: Epidemiology and Biometry Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803045.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 308067-58-5.  Subject Subsets: Protozoology
N2  - A population-based household survey was performed to evaluate the epidemiology of ocular toxoplasmosis in Rio Grande do Sul because of the frequency of this disease and its occurrence in multiple siblings in southern Brazil. Of 1042 individuals examined, 184 (17.7%) were found to have ocular toxoplasmosis and, of these, 183 (99.5%) had specific IgG antibodies, compared with only 140 (77.4%) from 181 age-matched controls. The prevalence of ocular toxoplasmosis was 0.9% in 1-8 year-olds, 4.3% in 9-12 year-olds, 14.3% in 13-16 year-olds, and 21.3% in all individuals older than 13 years. The prevalence of ocular toxoplasmosis in this population was more than 30 times higher than previous estimates for the same condition elsewhere. The low prevalence in the youngest children supports the hypothesis that, in this population, ocular toxoplasmosis is a sequel to post-natal infection rather than a congenital infection.
KW  - children
KW  - epidemiology
KW  - eye diseases
KW  - IgG
KW  - parasites
KW  - toxoplasmosis
KW  - Brazil
KW  - Rio Grande do Sul
KW  - man
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Brazil
KW  - prevalence
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gastrointestinal infections in AIDS.
A2  - Smith, P. D.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1992///
VL  - 116
IS  - 1
SP  - 63
EP  - 77
SN  - 0003-4819
AD  - National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211476.  Publication Type: Journal Article.  Language: English.  Number of References: 168 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - An edited summary of a Clinical Staff Conference on gastrointestinal infections in AIDS patients held at National Institutes of Health, Maryland, is presented. Diagnostic evaluation is discussed, followed by viral pathogens, fungal infections (Candida albicans and Histoplasma capsulatum), protozoan infections (Cryptosporidium, Isospora belli, Enterocytozoon bieneusi, Entamoeba histolytica, Giardia lamblia and Blastocystis hominis) and bacterial infections. Mechanisms of mucosal immunity in relation to AIDS, role of humoral immunity in the response to intestinal pathogens and therapeutic strategies for enteric infections in HIV-infected patients are also included.
KW  - acquired immune deficiency syndrome
KW  - digestive tract
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - infections
KW  - Opportunistic infections
KW  - parasites
KW  - predisposition
KW  - Candida albicans
KW  - Histoplasma capsulatum
KW  - man
KW  - Protozoa
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Histoplasma
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - invertebrates
KW  - AIDS
KW  - Ajellomyces capsulatus
KW  - fungus
KW  - gastrointestinal tract
KW  - human immunodeficiency virus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Itraconazole-digoxin interaction.
AU  - Rex, J.
T2  - Annals of Internal Medicine
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1992///
VL  - 116
IS  - 6
SP  - 525
EP  - 525
SN  - 0003-4819
AD  - Rex, J.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211690.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Registry Number: 20830-75-5, 84625-61-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 68-yr-old man with Sporothrix schenckii osteoarthritis of the right elbow, who failed to respond to saturated solution of KI or ketoconazole. The patient was receiving digoxin (0.25 mg bid) and ibuprofen for atrial fibrillation. After 2 wks of itraconazole treatment (400 mg/d), the patient developed nausea and fatigue, which was shown to be due to itraconazole, and digoxin levels rose. It is concluded that the addition of itraconazole to this patient's previously stable digoxin regimen produced signs and symptoms of digoxin toxicity along with an elevated digoxin level. Satisfactory digoxin levels were achieved on 25% of the patient's original dose of digoxin.
KW  - antagonism
KW  - Antifungal agents
KW  - digoxin
KW  - hosts
KW  - infections
KW  - itraconazole
KW  - joints (animal)
KW  - therapy
KW  - USA
KW  - man
KW  - Sporothrix schenckii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Sporothrix
KW  - Ophiostomataceae
KW  - Ophiostomatales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Differential localization of Acanthamoeba myosin I isoforms.
AU  - Baines, I. C.
AU  - Brzeska, H.
AU  - Korn, E. D.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1992///
VL  - 119
IS  - 5
SP  - 1193
EP  - 1203
SN  - 0021-9525
AD  - Baines, I. C.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804802.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology
N2  - Acanthamoeba castellanii myosins IA and IB were localized by immunofluorescence and immunoelectron microscopy in vegetative and phagocytosing cells and the total cell contents of myosins IA, IB and IC were quantified by immunoprecipitation. The quantitative distributions of the 3 myosin I isoforms were then calculated from these data and from the previously determined localization of myosin IC. Myosin IA occurs almost exclusively in the cytoplasm, where it accounts for ~50% of the total myosin I, in the cortex beneath phagocytic cups and in association with small cytoplasmic vesicles. Myosin IB is the predominant isoform associated with the plasma membrane, large vacuole membranes and phagocytic membranes and accounts for almost half of the total myosin I in the cytoplasm. Myosin IC accounts for a significant fraction of the total myosin I associated with the plasma membrane and large vacuole membranes and is the only myosin I isoform associated with the contractile vacuole membrane. These data suggest that myosin IA may function in cytoplasmic vesicle transport and myosin I-mediated cortical contraction, myosin IB in pseudopod extension and phagocytosis, and myosin IC in contractile vacuole function. In addition, endogenous and exogenously added myosins IA and IB appeared to be associated with the cytoplasmic surface of different subpopulations of purified plasma membranes implying that the different myosin I isoforms are targeted to specific membrane domains through a mechanism that involves more than the affinity of the myosins for anionic phospholipids.
KW  - biochemistry
KW  - myosins
KW  - parasites
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - isoforms
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Maternal vitamin levels during pregnancies producing infants with neural tube defects.
AU  - Mills, J. L.
AU  - Tuomilehto, J.
AU  - Yu, K. F.
AU  - Colman, N.
AU  - Blaner, W. S.
AU  - Koskela, P.
AU  - Rundle, W. E.
AU  - Forman, M.
AU  - Toivanen, L.
AU  - Rhoads, G. G.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1992///
VL  - 120
IS  - 6
SP  - 863
EP  - 871
SN  - 0022-3476
AD  - Mills, J. L.: Pediatric Epidemiology Section, Epidemiology Branch, DESPR, National Institute of Child Health and Human Development, National Institute of Health, EPN Bldg., Room 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931461509.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Human Nutrition
N2  - Folate, vitamin B12 and retinol levels were estimated in maternal serum drawn early in 89 pregnancies resulting in neural tube defects (NTD) offspring and 178 control pregnancies identified from the Finnish Registry of Congenital Malformations. In 86.5% of the subjects, specimens were collected within 8 weeks after neural tube closure. In the NTD case mothers the mean (±SD) levels were not significantly lower than in controls: folate, 4.13±2.36 vs. 4.28±2.52 ng/ml; vitamin B12, 482.8±161.1 vs. 520.3±191.9 pg/ml; and retinol, 51.2±17.0 vs. 50.5±16.9 µg/100 ml. After adjustment for age of the specimen, gestational age at which the specimen was drawn, maternal age and maternal employment status, the odds ratios for being a case mother were 1.00 (95% confidence interval (CI) 0.91 to 1.10) for folate, 1.05 (95% CI 0.92 to 1.19) for vitamin B12 and 0.99 (95% CI 0.88 to 1.10) for retinol. Excluding NTD cases with known or suspected causes unrelated to vitamins, restricting the analyses to interviewed subjects, and excluding subjects whose specimens were collected after 15 gestational weeks confirmed that NTD case and control vitamin levels did not differ significantly. This population-based investigation in a low rate area demonstrated no relationship between maternal serum folate, vitamin B12, or retinol levels during pregnancy and the risk of NTDs.
KW  - Congenital abnormalities
KW  - nervous system
KW  - nutritional state
KW  - pregnancy
KW  - vitamins
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - birth defects
KW  - congenital malformations
KW  - gestation
KW  - nutritional status
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Safety and pharmacokinetics of fluconazole in children with neoplastic diseases.
AU  - Lee, J. W.
AU  - Seibel, N. L.
AU  - Amantea, M.
AU  - Whitcomb, P.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1992///
VL  - 120
IS  - 6
SP  - 987
EP  - 993
SN  - 0022-3476
AD  - Lee, J. W.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931214969.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety, tolerance and pharmacokinetics of fluconazole was evaluated in 26 children (13 boys, 13 girls, aged 5-15 yr) receiving treatment for cancer. Intravenous fluconazole was given for a 2 h period, in doses of 2, 4 or 8 mg/kg daily for 7 d. No nausea or vomiting related to fluconazole was reported. An asymptomatic rise in hepatic aminotransferase values was seen in 3 patients after 4-6 doses (1 patient at 2 mg/kg and 2 at 8 mg/kg daily) which returned to normal within 2 wk of discontinuation of the drug. Fluconazole showed linear first-order kinetics over the dosage range tested and during multiple dosing. After the 1st dose, mean clearance was 22.8±2.3 ml/min, volume of distribution 0.8±0.06 litre/kg and terminal elimination half-life 16.8±1.1 h and after the last dose, these values were 19.4±1.3 ml/min, 0.84±0.04 litre/kg and 18.1±1.2 h, respectively. After a 1st dose of 8 mg/kg, peak and trough serum levels achieved 24 h later were 9.5±0.4 and 2.7±0.5 µg/ml, respectively, and an area under the serum concn-time from time zero to infinity of 186±16 µg/h per ml was achieved. Renal clearance of fluconazole was 65±5% of total clearance and demonstrated the predominantly renal excretion of this drug.
KW  - Antifungal agents
KW  - children
KW  - Fluconazole
KW  - pharmacokinetics
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fungistats
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Defining the population of human immunodeficiency virus-infected children at risk for Mycobacterium avium-intracellulare infection.
AU  - Lewis, L. L.
AU  - Butler, K. M.
AU  - et al.
AU  - Husson, R. N. (
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1992///
VL  - 121
IS  - 5
SP  - 677
EP  - 683
SN  - 0022-3476
AD  - Lewis, L. L.: Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942024160.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - [The authors] reviewed the 22 cases of Mycobacterium avium-intracellulare (MAI) infection that occurred among 196 human immunodeficiency virus-infected children seen at the National Cancer Institute Pediatric Branch from December 1986 through April 1991, and an additional 65 charts from children with cultures negative for MAI. All patients with proven MAI were receiving antiretroviral therapy with zidovudine, dideoxyinosine, or a combination of zidovudine and dideoxycytidine. All patients had disseminated MAI infection, except one adolescent who had only evidence of localized lymphadenitis. All cases of MAI but one were diagnosed before death. The overall incidence of MAI was 11% in [the] patients but increased to 24% in patients whose absolute CD4 cell counts were &lt;100 cells/mm³. Symptoms most commonly associated with MAI infection included recurrent fever (86% of patients), weight loss or failure to thrive (64%), neutropenia (55%), night sweats (32%), and abdominal pain (27%). Children infected with MAI had a mean CD4 percentage of 2% (range, 0% to 7%) and a mean absolute CD4 count of 12 cells/mm³ (range, 0 to 48 cells/mm³), significantly lower than in the remainder of the clinic population or the group of children with cultures negative for MAI. Of 20 patients with MAI infection who were tested, 10 had measurable p24 antigen with a mean value 939 pg/ml (range, 77 to 3270 pg/ml) compared with 19 of 59 patients without MAI infection in whom the mean positive value was 413 pg/ml. There was no difference in survival time between those children with documented MAI infection (median survival time, 45.5 weeks) and those with similarly low CD4 counts and cultures negative for MAI (median survival time, 50.4 weeks). Future improvements in therapeutic options may make screening of pediatric human immunodeficiency virus-infected patients with low CD4 counts a reasonable plan. AS
KW  - human immunodeficiency viruses
KW  - infections
KW  - risk factors
KW  - North America
KW  - USA
KW  - Mycobacterium
KW  - Mycobacterium avium complex
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - bacterium
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - infections Mycobacterium aviumminusintracellulare
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Combination treatment with azidothymidine and granulocyte colony-stimulating factor in children with human immunodeficiency virus infection.
AU  - Mueller, B. U.
AU  - Jacobsen, F.
AU  - Butler, K. M.
AU  - Husson, R. N.
AU  - Lewis, L. L.
AU  - Pizzo, P. A.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1992///
VL  - 121
IS  - 5
SP  - 797
EP  - 802
SN  - 0022-3476
AD  - Mueller, B. U.: (P.A. Pizzo) Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005936.  Publication Type: Journal Article.  Language: English.  Registry Number: 30516-87-1. 
KW  - Combination therapy
KW  - HIV infections
KW  - Neutropenia
KW  - Paediatrics
KW  - Treatment
KW  - Zidovudine
KW  - AZT
KW  - combined modality therapy
KW  - Granulocyte colony stimulating factor
KW  - human immunodeficiency virus infections
KW  - multimodal treatment
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - OxyR: a regulator of antioxidant genes.
AU  - Storz, G.
AU  - Tartaglia, L. A.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1992///
VL  - 122
IS  - 3S
SP  - 627
EP  - 630
SN  - 0022-3166
AD  - Storz, G.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18, Bethesda, MD 20817, USA.
N1  - Accession Number: 19921446206.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - The study of the bacterial response to hydrogen peroxide has given general insights into how cells defend against deleterious oxidants. Treatment of Salmonella typhimurium and Escherichia coli cells with low doses of hydrogen peroxide results in the induction of 30 proteins and resistance to killing by higher doses of hydrogen peroxide. The expression of 9 of the hydrogen peroxide-inducible proteins, including the antioxidant enzymes catalase, glutathione reductase and an alkyl hydroperoxide reductase, is controlled by the positive regulator oxyR. Strains carrying deletions of the oxyR gene are hypersensitive to hydrogen peroxide and have increased levels of spontaneous mutagenesis during aerobic growth. The OxyR protein is homologous to the LysR-NodD family of bacterial regulatory proteins and binds to the promoters of oxyR-regulated genes. The oxidized, but not the reduced, form of the OxyR protein activates transcription of oxyR-regulated genes in vitro, suggesting that direct oxidation of the OxyR protein brings about a confirmation change by which OxyR senses an oxidative stress signal and then activates the expression of defense activities.
KW  - Antioxidants
KW  - genes
KW  - regulation
KW  - reviews
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of a model for selenite metabolism in humans.
AU  - Patterson, B. H.
AU  - Zech, L. A.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1992///
VL  - 122
IS  - 3S
SP  - 709
EP  - 714
SN  - 0022-3166
AD  - Patterson, B. H.: Biometry Branch, Executive Plaza North, Suite 344, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921446268.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
N2  - The process of building a kinetic model for the metabolism of selenite in man is described. Plasma, urine and faecal data from a selenium pharmacokinetics study are compared with an a priori model hypothesized before the study was conducted. The reasons for the rejection of the model are given. The iterative process of observing the fit of the model, modifying the model and testing the modification is illustrated by using as examples an intermediate model and a current working model. Several specific problems encountered in trying to fit the a priori and the intermediate model are described along with the approaches taken to resolve them. Finally, some uses of the current model are given, including checking an assumption underlying the pharmacokinetics study, making predictions about the effect of supplementation on plasma values and developing research leads.
KW  - mathematical models
KW  - metabolism
KW  - reviews
KW  - Selenium
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nonparticipation as a determinant of adverse health outcomes in a field trial of oral cholera vaccines.
AU  - Clemens, J. D.
AU  - Loon, F. F. P. L. van
AU  - et al.
AU  - Sack, D. A. (
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1992///
VL  - 135
IS  - 8
SP  - 865
EP  - 874
SN  - 0002-9262
AD  - Clemens, J. D.: Prevention Research Program, National Institute of Child Health and Human Development, Executive Plaza North Building, Room 640, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020120.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - The authors estimated the incidence rates of cholera and death between 1985 and 1988 for 32 642 age- and sex-eligible persons who did not participate in a randomized, placebo-controlled field trial of killed oral cholera vaccines in rural Bangladesh. As compared with 20 744 placebo recipients, the relative risk of cholera for all nonparticipants, adjusted for potentially confounding demographic variables, was 1.20 (95% confidence interval (CI) 1.03-1.41); this adjusted relative risk reflected elevated adjusted relative risks in nonparticipants who were medically ineligible (RR = 1.65; 95% CI 1.22-2.22) or refused to participate (RR = 1.19; 95% CI 1.01-1.41), but not in persons absent at the time of vaccination (RR = 1.00; 95% CI 0.78-1.28). The adjusted relative risk of death was also elevated in nonparticipants as compared with placebo recipients (RR = 1.28; 95% CI 1.10-1.48), with the same pattern of adjusted relative risks for different categories of nonparticipants: for ineligible subjects, 2.64 (95% CI 2.12-3.29); for refusers, 1.20 (95% CI 1.02-1.41); and for absentees, 0.95 (95% CI 0.75-1.22). The authors concluded that nonparticipation was associated with clinically cogent adverse health outcomes, but that the magnitude of these associations varied according to the reason for nonparticipation. These findings underscore the caution required in assessing vaccine efficacy with controls who are not vaccinated because of choices made by patients or vaccinators. AS
KW  - Cholera
KW  - immunization
KW  - mouth
KW  - trials
KW  - vaccines
KW  - Asia
KW  - Bangladesh
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - cooperative behaviour
KW  - immune sensitization
KW  - killed
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diet and other risk factors for laryngeal cancer in Shanghai, China.
AU  - Zheng, W.
AU  - Blot, W. J.
AU  - Shu, X. O.
AU  - Gao, Y. T.
AU  - Ji, B. T.
AU  - Ziegler, R. G.
AU  - Fraumeni, J. F., Jr.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1992///
VL  - 136
IS  - 2
SP  - 178
EP  - 191
SN  - 0002-9262
AD  - Zheng, W.: National Cancer Institute, Executive Plaza North, Room 431, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931454756.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - A population-based, case-control study of laryngeal cancer was conducted in Shanghai, China, during 1988-1990, in which 177 males and 24 females diagnosed as having laryngeal cancer and 269 males and 145 females (controls) were interviewed. Cigarette smoking was the major risk factor, accounting for 86% of the male and 54% of the female cases. After adjusting for smoking, there was little increase in risk associated with drinking alcoholic beverages. Among men, cases more often reported occupational exposures to asbestos and coal dust. A protective effect was associated with the intake of fruits (particularly oranges and tangerines), some dark green/yellow vegetables, and garlic, but there was an increased risk with the intake of salt-preserved meat and fish. Results suggest that risk factors for laryngeal cancer in Shanghai resemble those in Western countries, and they provide further evidence that dietary factors have an important aetiologic role.
KW  - alcoholic beverages
KW  - Carcinoma
KW  - diet
KW  - larynx
KW  - China
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - People's Republic of China
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - How much of the recent rise in breast cancer incidence can be explained by increases in mammography utilization? A dynamic population model approach.
AU  - Feuer, E. J.
AU  - Wun, L. M.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1992///
VL  - 136
IS  - 12
SP  - 1423
EP  - 1436
SN  - 0002-9262
AD  - Feuer, E. J.: Division of Cancer Prevention and Control, National Cancer Institute, EPN 313, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020723.  Publication Type: Journal Article.  Language: English. 
N2  - The authors developed a model that is based on that by White et al. (Journal of the National Cancer Institute 1990; 82: 1546-52) that incorporate estimates of differential lead time by age group. This model shows that if older women have longer lead times, some mammography usage across age groups will result in a larger increase in older womens' incidence. Therefore, the increases in mammography usage are in accord with increases in incidence, across all age groups.Danielle Horton.
KW  - age groups
KW  - breast cancer
KW  - human diseases
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - mammary tumour
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020723&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China.
AU  - Shu, X. O.
AU  - Zheng, W.
AU  - et al.
AU  - Potischman, N. (
AU  - Brinton, L. A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1992///
VL  - 137
IS  - 2
SP  - 155
EP  - 165
SN  - 0002-9262
AD  - Shu, X. O.: (L.A. Brinton) Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020725.  Publication Type: Journal Article.  Language: English. 
KW  - neoplasms
KW  - China
KW  - Shanghai
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - Eastern China
KW  - China
KW  - cancers
KW  - People's Republic of China
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Small subunit ribosomal RNA of Blastomyces dermatitidis: sequence and phylogenetic analysis.
AU  - Geber, A.
AU  - Higgins, D. E.
AU  - Waters, A. P.
AU  - Bennett, J. E.
AU  - McCutchan, T. F.
JO  - Journal of General Microbiology
JF  - Journal of General Microbiology
Y1  - 1992///
VL  - 138
IS  - 2
SP  - 395
EP  - 399
SN  - 0022-1287
AD  - Geber, A.: Laboratory of Clinical Investigation and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211133.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology; Agricultural Biotechnology
N2  - The small subunit (18S) ribosomal RNA sequence of B. dermatitidis was determined. The sequence was compared with that of 14 other eukaryotic organisms, 10 of which were higher fungi, and an evolutionary tree was constructed based on these sequences. B. dermatitidis aligned most closely with the ascomycetes Neurospora crassa and Podospora anserina, in agreement with previous phylogenetic analysis based on morphological criteria. Phase-specific cDNA clone derived by reverse transcription of RNA isolated from the yeast and mycelial phases of B. dermatitidis were also sequenced. The 18S ribosome sequence was found to be the same in both phases. Heterogeneity was found at both the genomic and RNA level at position 1352.
KW  - Biotechnology
KW  - genetics
KW  - nucleotide sequences
KW  - Ribosomal DNA
KW  - ribosomal RNA
KW  - taxonomy
KW  - Blastomyces dermatitidis
KW  - Blastomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - DNA sequences
KW  - fungus
KW  - rRNA
KW  - systematics
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of a genomic group of Borrelia burgdorferi through signature nucleotide analysis and 16S rRNA sequence determination.
AU  - Marconi, R. T.
AU  - Garon, C. F.
JO  - Journal of General Microbiology
JF  - Journal of General Microbiology
Y1  - 1992///
VL  - 138
IS  - 3
SP  - 533
EP  - 536
SN  - 0022-1287
AD  - Marconi, R. T.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515927.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - As part of a continuing effort to assess genetic variation among isolates of B. burgdorferi, the 16S rRNA signature nucleotide makeup of 2 tick (Ixodes persulcatus) isolates from Russia were determined. Signature nucleotides were identified via reverse transcriptase primer extension sequencing of select regions of the 16S rRNA molecule. In addition, the near complete 16S rRNA sequence of one of the isolates, R-IP3, was determined and utilized in a phylogenetic assessment. The sequence was aligned with the 16S rRNA sequences of other B. burgdorferi isolates, as well as with other Borrelia species (B. anserina, B. coriaceae, B. hermsii). Distance matrix analyses were performed and a phylogenetic tree was constructed. These analyses demonstrated that these isolates belong to a third previously unidentified genomic group of B. burgdorferi.
KW  - genome analysis
KW  - molecular genetics
KW  - Nucleotide sequences
KW  - Ribosomal RNA
KW  - Russia
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - rRNA
KW  - Russian Federation
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515927&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The molecular analysis of synonymy among medically important yeasts within the genus Candida.
AU  - Wickes, B. L.
AU  - Hicks, J. B.
AU  - Merz, W. G.
AU  - Kwon-Chung, K. J.
JO  - Journal of General Microbiology
JF  - Journal of General Microbiology
Y1  - 1992///
VL  - 138
IS  - 5
SP  - 901
EP  - 907
SN  - 0022-1287
AD  - Wickes, B. L.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921211854.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Three sets of medically important yeasts, C. albicans, C. tropicalis and C. krusei, were compared with their putative synonyms (C. langeronii and C. claussenii, C. paratropicalis, and Itssatchenkia orientalis, respectively) to determine if these synonyms are genetically distinguishable from each other. Pulsed-field electrophoresis and hybridization to species-specific probes were used. The species-specific probes for C. albicans and C. tropicalis have been previously described (27A and CT13.8, respectively) whereas the probe for C. krusei (CK3) was cloned. No distinguishing characteristics between synonyms were identified, supporting the current taxonomic treatment of these organisms.
KW  - Biotechnology
KW  - molecular biology
KW  - taxonomy
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida tropicalis
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida krusei
KW  - fungus
KW  - Hyphomycetes
KW  - systematics
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211854&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cystitis induced by infection with the Lyme disease spirochete, Borrelia burgdorferi, in mice.
AU  - Czub, S.
AU  - Duray, P. H.
AU  - Thomas, R. E.
AU  - Schwan, T. G.
JO  - American Journal of Pathology
JF  - American Journal of Pathology
Y1  - 1992///
VL  - 141
IS  - 5
SP  - 1173
EP  - 1179
SN  - 0002-9440
AD  - Czub, S.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-Borne Diseases Section, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940805925.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - Previous studies have shown that the urinary bladder is a consistent source for isolating B. burgdorferi from both experimentally infected and naturally exposed rodents. In this study, histopathological changes in the urinary bladder were examined in a variety of rodents experimentally infected with B. burgdorferi. Spirochaetes were cultured from the urinary bladder of all 35 mice inoculated with low-passaged spirochaetes, but none were cultured from the kidneys of the same mice. The pathological changes observed most frequently in the urinary bladder were the presence of lymphoid aggregates, vascular changes and thickening of the vessel walls. The results demonstrated that 93% of the animals examined had a cystitis associated with spirochaetal infection.
KW  - bladder
KW  - cystitis
KW  - Lyme disease
KW  - pathology
KW  - Borrelia burgdorferi
KW  - mice
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - lyme borreliosis
KW  - urinary bladder
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805925&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pulmonary involvement in loiasis.
AU  - Klion, A. D.
AU  - Eisenstein, E. M.
AU  - Smirniotopoulos, T. T.
AU  - Neumann, M. P.
AU  - Nutman, T. B.
JO  - American Review of Respiratory Disease
JF  - American Review of Respiratory Disease
Y1  - 1992///
VL  - 145
IS  - 4,I
SP  - 961
EP  - 963
SN  - 0003-0805
AD  - Klion, A. D.: T.B. Nutman, National Institutes of Health, Laboratory of Parasitic Diseases, Bldg. 4, Rm. 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878275.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Helminthology
N2  - A 40-year-old Ghanaian man was admitted to hospital in Maryland, USA, with acute pleural effusion. Cytological evaluation of the pleural fluid revealed Loa loa microfilariae. No additional aetiology for the pleural effusion could be identified, and antifilarial treatment with diethylcarbamazine (a 50-mg test dose followed by an increase in dose gradually over 4 days to 8 mg/kg/day in 3 divided doses) led to a rapid resolution of the patient's symptoms and pulmonary abnormalities. It is considered that Loa loa must be considered as a treatable cause of eosinophilic pleural effusions in persons from endemic areas of West and Central Africa.
KW  - Case reports
KW  - Eosinophilia
KW  - helminths
KW  - Human diseases
KW  - Imported infections
KW  - Loiasis
KW  - Lungs
KW  - parasites
KW  - Pleura
KW  - Africa
KW  - Ghana
KW  - Maryland
KW  - North America
KW  - USA
KW  - Loa loa
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - African eyeworm
KW  - loaosis
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diagnosis of Pneumocystis carinii pneumonia by multiple lobe, site-directed bronchoalveolar lavage with immunofluorescent monoclonal antibody staining in human immunodeficiency virus-infected patients receiving aerosolized pentamidine chemoprophylaxis.
AU  - Levine, S. J.
AU  - Kennedy, D.
AU  - Shelhamer, J. H.
AU  - Kovacs, A.
AU  - Feuerstein, I. M.
AU  - Gill, V. J.
AU  - Stock, F.
AU  - Solomon, D.
AU  - Boylen, C. T.
AU  - Masur, H.
AU  - Ognibene, F. P.
JO  - American Review of Respiratory Diseases
JF  - American Review of Respiratory Diseases
Y1  - 1992///
VL  - 146
IS  - 4
SP  - 838
EP  - 843
AD  - Levine, S. J.: Critical Care Medicine Department, Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920801046.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Protozoology
N2  - The yields of both induced sputum examination and bronchoalveolar lavage (BAL) have been reported to be decreased for breakthrough episodes of P. carinii pneumonia in HIV-infected patients receiving aerosolized pentamidine chemoprophylaxis. This study assessed whether the yield of a single middle or lower lobe BAL could be increased by the utilization of 2 techniques: indirect immunofluorescent staining with a combinate of 2 murine monoclonal anti-Pneumocystis antibodies in addition to routine toluidine blue O and cytopathologic staining, and the performance of multiple lobe, site-directed BAL (i.e., both upper lobe and middle or lower lobe lavage, including the lobe with the greatest radiographic abnormality). Results of 252 fiberoptic bronchoscopies performed at the National Institutes of Health, Maryland and the Los Angeles County-University of Southern California Medical Center were analyzed. P. carinii pneumonia was documented in 21 episodes in patients who did not receive prior anti-Pneumocystis chemoprophylaxis and in 41 episodes in patients who received aerosolized pentamidine. MAb staining and multiple lobe, site-directed BAL resulted in similar diagnostic yields for P. carinii in the nonprophylaxis (100%) and aerosolized pentamidine (98%) groups. If BAL had been performed without MAb staining and multiple lobe, site-directed lavage, than the yield would have decreased to 95% in the nonprophylaxis group and to 80% in the aerosolized pentamidine group. When the yields for single middle or lower lobe BAL without MAb staining and multiple lobe, site-directed BAL with MAb staining were compared in patients receiving aerosolized pentamidine, the sensitivity was significantly improved when both supplemental techniques were used (98% versus 80%). These data suggest that the use of both immunofluorescent MAB staining and multiple lobe, site-directed BAL. In addition to middle or lower lobe lavage and conventional staining techniques, can maintain the high positive yield of BAL for P. carinii in patients receiving aerosolized pentamidine chemoprophylaxis.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Bronchoalveolar lavage
KW  - diagnosis
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - immunodiagnosis
KW  - Monoclonal antibodies
KW  - Opportunistic infections
KW  - parasites
KW  - Staining
KW  - California
KW  - Maryland
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - serological diagnosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages.
AU  - Gazzinelli, R. T.
AU  - Oswald, I. P.
AU  - James, S. L.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 148
IS  - 6
SP  - 1792
EP  - 1796
SN  - 0022-1767
AD  - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930807498.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 130068-27-8.  Subject Subsets: Helminthology; Protozoology
N2  - It was shown that interleukin-10 (IL-10) (which is produced by Th2 CD4+ T lymphocytes) can down-regulate IFN-γ-dependent immunity by blocking the ability of that lymphokine to activate macrophages. Thus, IL-10, in a dose-dependent manner, inhibited the microbicidal activity of IFN-γ-treated inflammatory macrophages against intracellular Toxoplasma gondii (RH strain) and the extracellular killing of schistosomula of Schistosoma mansoni. This suppression correlated with the inhibition by IL-10 of IFN-γ-induced production of toxic nitrogen oxide metabolites, an effector mechanism previously implicated in the killing by macrophages of both parasite targets. IL-10 inhibition of nitric oxide production was shown to occur when the cytokine was given before or together with the IFN-γ-activating stimulus, but not after the cells had been previously activated, and to require 12 h of contact for maximal suppressive effect on macrophage function. These results, taken together with previous findings on the down-regulation of Th1 lymphokine production by IL-10, indicate that the induction of IL-10 may be an important strategy by which parasites evade IFN-γ-dependent, cell-mediated immune destruction.
KW  - Cytokines
KW  - helminths
KW  - Human diseases
KW  - Immunology
KW  - immunosuppression
KW  - in vitro
KW  - interleukin 10
KW  - macrophages
KW  - parasites
KW  - Apicomplexa
KW  - Digenea
KW  - protozoa
KW  - Sarcocystidae
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Toxoplasma gondii
KW  - Trematoda
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Trematoda
KW  - Platyhelminthes
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807498&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment with anti-IL2 antibodies reduces hepatic pathology and eosinophilia in Schistosoma mansoni-infected mice while selectively inhibiting T cell IL-5 production.
AU  - Cheever, A. W.
AU  - Finkelman, F. D.
AU  - Caspar, P.
AU  - Heiny, S.
AU  - Macedonia, J. G.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 148
IS  - 10
SP  - 3244
EP  - 3248
SN  - 0022-1767
AD  - Cheever, A. W.: Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879291.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Helminthology
N2  - In vivo treatment of S. mansoni (NMRI strain) infected C3H/HeN female mice with anti-IL-2 antibodies, with or without anti-IL-2 receptor antibodies, significantly diminished the size of circumoval granulomas in the liver and decreased hepatic fibrosis to half that in untreated mice. Antibody treated animals also displayed a marked reduction in both peripheral blood and tissue eosinophilia while IgE levels were unchanged or increased. Spleen cell cytokine production in response to antigen or mitogen stimulation was selectively altered by in vivo anti-IL2 administration. IL-5 responses were dramatically reduced, whereas IL-4, IL-2, and IFN-γ responses were not consistently changed. These findings confirm previous observations, suggesting a role for IL-2 in egg-induced pathology but indicate that the primary function of this cytokine in schistosome-infected mice may be in the generation of Th2- rather than Th1-associated responses.
KW  - Cytokines
KW  - Eosinophils
KW  - Granuloma
KW  - helminths
KW  - Human diseases
KW  - immunopathology
KW  - Interleukins
KW  - Laboratory animals
KW  - parasites
KW  - T lymphocytes
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - eosinophil leukocytes
KW  - immunopathogenesis
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Parallel regulation of IL-4 and IL-5 in human helminth infections.
AU  - Mahanty, S.
AU  - Abrams, J. S.
AU  - King, C. L.
AU  - Limaye, A. P.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 148
IS  - 11
SP  - 3567
EP  - 3571
SN  - 0022-1767
AD  - Mahanty, S.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802603.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 37341-29-0, 308067-57-4, 148641-02-5, 207137-56-2.  Subject Subsets: Helminthology
N2  - To investigate the relationship between cytokine production and the increased levels of serum IgE and peripheral eosinophilia commonly accompanying human helminth infections, the ability of PMBC of normal (N1) (n = 18) and eosinophilic individuals with helminth infections (H1) (n = 9) to produce IL-3, Il-4, IL-5, granulocyte-macrophage-CSF, and IFN-γin vitro after stimulation with PMA (50 ng/ml) and ionomycin (1 µg/ml) was investigated. The 2 groups differed in both the levels of serum IgE and eosinophilia. In H1, 4 were infected wih Loa loa, one with Strongyloides, 3 with Onchocerca volvulus and one had lymphatic filariasis. For mitogen-induced production of granulocyte-macrophage-CSF and IFN-γ, there was no difference in cytokine production between the 2 groups. In marked contrast, supernatants from PBMC of infected individuals had significantly higher levels of IL-4 (mean = 213 pg/ml for N1 and 944 pg/ml for H1), IL-5 (mean = 180 pg/ml for N1 and 1118 pg/ml for HL), and IL-3 (mean = 13 900 pg/ml for N1, 28 029 pg/ml for H1). In addition, helminth-infected patients had ~5-fold greater numbers of T cells capable of producing IL-5 and 2.5-fold greater frequency of IL-4-secreting cells than did normal individuals; GM-CSF- and IFN-γ-producing T cell numbers were not significantly different in the 2 groups. IL-3-producing cell frequencies could not be evaluated by this method. There was a direct correlation between IL-4 production and IL-5 production at the level of both protein production and frequency of T cells capable of producing these cytokines. The data indicated that individuals with reactive eosinophilia and elevated serum IgE have an expanded population of lymphocytes producing IL-4 and IL-5 and the association of the 2 suggests that the regulation of IL-4 and IL-5 may be linked.
KW  - Cytokines
KW  - Eosinophils
KW  - Helminths
KW  - Human diseases
KW  - IgE
KW  - immune response
KW  - Immunoglobulins
KW  - Interleukin 3
KW  - Interleukin 4
KW  - Interleukin 5
KW  - parasites
KW  - T lymphocytes
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - eosinophil leukocytes
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity.
AU  - Oswald, I. P.
AU  - Gazzinelli, R. T.
AU  - Sher, A.
AU  - James, S. L.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 148
IS  - 11
SP  - 3578
EP  - 3582
SN  - 0022-1767
AD  - Oswald, I. P.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802605.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 130068-27-8, 207137-56-2.  Subject Subsets: Helminthology
N2  - After activation with IFN-γ, thioglycollate-elicited murine peritoneal macrophages kill schistosomula of Schistosoma mansoni in vitro by an L-arginine-dependent mechanism which involves the production of reactive nitrogen oxides (NO). In this study it was shown that the regulatory cytokines IL-10, IL-4, and transforming growth factor-β (TGF-β) are potent inhibitors of this extracellular killing function of activated macrophages. Each cytokine was found to suppress killing of schistosomula in a dose-dependent fashion. The activity of IL-10 was not permanent, because subsequent treatment with additional IFN-γ 2 to 6 h later reversed the inhibition of macrophage larval killing. More importantly, the combination of suboptimal levels of any 2 of these 3 cytokines was found to give a potent synergistic suppression of schistosomulum killing by IFN-γ-treated macrophage. Similarly, IL-10, IL-4, or TGF-β alone blocked the production of NO, and when used in combination these cytokines exhibited an enhanced inhibitory effect on nitrite production. Macrophage-mediated killing of schistosomula through the generation of NO has been shown previously to be a major effector mechanism of schistosome immunity. The results presented suggest that the suppression of this mechanism by induction of the regulatory cytokines IL-10, IL-4 and TGF-β, which are known to be produced during schistosome infection, may be an important strategy used by the parasite to evade macrophage-mediated immune destruction.
KW  - Cytokines
KW  - helminths
KW  - Human diseases
KW  - Immune evasion
KW  - in vitro
KW  - Interleukin 10
KW  - Interleukin 4
KW  - macrophages
KW  - parasites
KW  - Digenea
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.
AU  - Gazzinelli, R.
AU  - Xu, Y. H.
AU  - Hieny, S.
AU  - Cheever, A.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 149
IS  - 1
SP  - 175
EP  - 180
SN  - 0022-1767
AD  - Gazzinelli, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879475.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology
N2  - C57BL/6 mice chronically infected with an avirulent strain (ME-49) of T. gondii were used to study the mechanisms by which T lymphocytes and IFN-γ prevent reactivation of latent infection. Infected animals were treated with MAbs either anti-CD8, anti-CD4, anti-CD4 plus anti-CD8, anti-IFN-γ, or anti-CD4 plus anti-IFN-γ. Treatment with anti-IFN-γ antibodies fully reactivated the asymptomatic infection, inducing massive necrotic areas in the brain with the appearance of free tachyzoites and death of all animals within 2 weeks. Mice treated with the combination of anti-CD4 plus anti-CD8 antibodies showed augmented pathology and mortality nearly identical to the anti-IFN-γ-treated animals. In contrast, treatment with anti-CD4 or anti-CD8 MAb alone failed to result in significantly enhanced brain pathology or mortality. In additional experiments, full reactivation of infection was observed in mice treated with anti-CD4 plus anti-IFN-γ indicating that CD4+ lymphocytes are not required for the pathology resulting from IFN-γ neutralization. Cytokine measurements on parasite antigen (Ag)-stimulated spleen cells from MAb-treated mice indicated that both CD4+ and CD8+ cells produce IFN-γ whereas only CD4+ cells contribute to parasite Ag-induced IL-2 synthesis. Together, these results suggest that CD4+ and CD8+ lymphocytes act additively or synergistically to prevent reactivation of chronic T. gondii infection probably through the production of IFN-γ.
KW  - Human diseases
KW  - Immunocompromised hosts
KW  - Laboratory animals
KW  - Monoclonal antibodies
KW  - Opportunistic infections
KW  - parasites
KW  - resistance
KW  - T lymphocytes
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - protozoa
KW  - Rodents
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1.
AU  - Hosmalin, A.
AU  - Kumar, S.
AU  - Barnd, D.
AU  - Houghten, R.
AU  - Smith, G. E.
AU  - Hughes, S. H.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 149
IS  - 4
SP  - 1311
EP  - 1318
SN  - 0022-1767
AD  - Hosmalin, A.: J.A. Berzofsky, Metabolism Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 6B-12, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920800117.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Protozoology
N2  - Cytotoxic T lymphocyte (CTL) lines specific for 2 different proteins derived from P. falciparum circumsporozoite protein and HIV-1 reverse transcriptase, were obtained by immunizing C3H/HeN mice with protein-pulsed syngeneic spleen cells. The lysis of the target cells was dependent on a class I MHC molecule and the accessory molecule CD8. Immunodominant epitopic peptides were identified previously in the 2 proteins using murine CTL derived after immunization with recombinant virus or sporozoites, or using CTL from HIV-1-infected patients. These peptides were also recognized by the CTL lines obtained after protein-pulsed spleen-cell immunization. A new CTL antigenic determinant was localized in HIV-1 reverse transcriptase to residues 514 to 528, a sequence that, if folded as an α-helix, would be strongly amphipathic. The determinant was tentatively narrowed, using overlapping peptides, to a core of a least 9 residues, 515 to 523. This site was also recognized by CTL obtained by the 3 different methods of immunization. Therefore, extracellular proteins incubated with spleen cells can be processed and presented in vivo in the same way as intracellular proteins, resulting in recognition of the same epitopes in association with the same class I MHC molecules. The potential implications for vaccine development and for the understanding of class I-restricted antigen presentation are discussed.
KW  - Circumsporozoite protein
KW  - Cytotoxic T lymphocytes
KW  - Human diseases
KW  - immunization
KW  - Laboratory animals
KW  - parasites
KW  - T lymphocytes
KW  - Vaccines
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - immune sensitization
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical and immunologic characterization of a major IgE-inducing filarial antigen of Brugia malayi and implications for the pathogenesis of tropical pulmonary eosinophilia.
AU  - Lobos, E.
AU  - Ondo, A.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1992///
VL  - 149
IS  - 9
SP  - 3029
EP  - 3034
SN  - 0022-1767
AD  - Lobos, E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920801530.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Registry Number: 37341-29-0.  Subject Subsets: Helminthology
N2  - A major allergen of B. malayi was identified by 2-dimensional immunoblot analysis using a serum pool from patients with tropical pulmonary eosinophilia. The allergen is composed of 2 antigens of 23 000 and 25 000 MW and acidic isoelectric point (Bm23-25). Immunoblots using affinity-purified IgE antibodies to BM23-25 indicated that Bm23-25 is expressed mainly in the microfilarial stage. Digestion of the allergen with endoglycosidases indicates that it has N-linked oligosaccharide chains. Analysis of the reactivity of T cells derived from patients with lymphatic filariasis revealed that the Bm23-25 allergen was capable of stimulating T cell proliferation; Bm23-25 was also shown to induce IgE production in vitro from peripheral blood mononuclear cells derived from patients with either tropical pulmonary eosinophilia (TPE) or other filarial symptoms. Bronchoalveolar lavage fluid of patients with TPE contained IgE antibodies that recognized Bm23-25 strongly, an observation suggesting that the microfilarial allergen might be involved in the pathogenesis of the TPE syndrome.
KW  - antigens
KW  - Filariids
KW  - helminths
KW  - Human diseases
KW  - IgE
KW  - parasites
KW  - pathogenesis
KW  - T lymphocytes
KW  - Brugia malayi
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - antigenicity
KW  - immunogens
KW  - nematodes
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Tropical pulmonary eosinophilia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Belgrade virus: a new hantavirus causing severe haemorrhagic fever with renal syndrome in Yugoslavia.
AU  - Gligic, A.
AU  - Dimkovic, N.
AU  - et al.
AU  - Xiao, S. Y. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1992///
VL  - 166
IS  - 1
SP  - 113
EP  - 120
SN  - 0022-1899
AD  - Gligic, A.: (R. Yanagihara) National Institutes of Health, Bldg. 36, Rm. 5B-21, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020556.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1-3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30 000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia.AS
KW  - blood
KW  - haemorrhagic fever with renal syndrome
KW  - haemorrhagic fevers
KW  - patients
KW  - urine
KW  - Europe
KW  - Yugoslavia
KW  - Balkans
KW  - Southern Europe
KW  - Europe
KW  - Mediterranean Region
KW  - Belgrade virus
KW  - hemorrhagic fever with renal syndrome
KW  - hemorrhagic fevers
KW  - Jugoslavia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
AU  - Levine, P. H.
AU  - Jahan, N.
AU  - Murari, P.
AU  - Manak, M.
AU  - Jaffe, E. S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1992///
VL  - 166
IS  - 2
SP  - 291
EP  - 295
SN  - 0022-1899
AD  - Levine, P. H.: National Cancer Institute, National Institutes of Health, Bldg. EPN, Rm. 434, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020438.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - After preliminary serologic data demonstrated elevated antibody titers to human herpesvirus (HHV) 6 in patients with sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease, tissues were examined from 9 patients with classical SHML to search for evidence of HHV-6 infection. Involved tissues from 7 of the 9 patients had detectable HHV-6 by in situ hybridization: tissue from 1 had detectable Epstein-Barr virus genome but no HHV-6 and tissue from another had no detectable HHV-6 or Epstein-Barr virus. These studies suggest that HHV-6 and, to a lesser extent, Epstein-Barr virus may be involved in the etiology of SHML. AS
KW  - viral diseases
KW  - Herpesviridae
KW  - human herpesvirus 6
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - RosaiminusDorfman disease
KW  - RosaiminusDorfman disease patients
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - UV light-induced reactivation of herpes simplex virus type 2 and prevention by acyclovir.
AU  - Rooney, J. F.
AU  - Straus, S. E.
AU  - et al.
AU  - Mannix, M. L. (
AU  - Notkins, A. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1992///
VL  - 166
IS  - 3
SP  - 500
EP  - 506
SN  - 0022-1899
AD  - Rooney, J. F.: (A.L. Notkins) Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Building 30, Room 121, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021182.  Publication Type: Journal Article.  Language: English.  Registry Number: 59277-89-3.  Subject Subsets: Public Health
KW  - aciclovir
KW  - Herpes simplex
KW  - latent infections
KW  - prevention
KW  - Human herpesvirus 2
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - acyclovir
KW  - herpes simplex virus 2
KW  - reactivation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Multistate outbreak of hepatitis A associated with frozen strawberries.
AU  - Niu, M. T.
AU  - Polish, L. B.
AU  - et al.
AU  - Robertson, B. H. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1992///
VL  - 166
IS  - 3
SP  - 518
EP  - 524
SN  - 0022-1899
AD  - Niu, M. T.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021185.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition; Public Health
N2  - "A multistate outbreak of hepatitis A was traced to frozen strawberries processed at a single plant. Among 827 students and 60 teachers at an elementary school in Georgia [USA] during a 2-week period, 15 developed hepatitis A. Three months later, among 174 residents and 467 staff in an institution for the developmentally disabled in Montana during a 3-week period, 13 developed hepatitis A. Primary attack rates were 10% in the school and 8% in the institution. Cohort analysis in the school implicated consumption of strawberry shortcake in hepatitis A virus (HAV) infection (relative risk, 7.6; 95% confidence interval, 1.04-55.6). In the institution, such analysis implicated desserts and uncooked strawberries as the most biologically plausible vehicle of HAV transmission. Molecular analysis of HAV from patients in the 2 outbreaks revealed that the viral genomes were genetically identical and distinct from other known US strains. Contamination of food products before retail distribution is rare but should be considered in investigating common-source outbreaks of hepatitis A". Empty frozen strawberry containers found in both institutions came from the same company in California which was investigated retrospectively. Strawberries were washed in chlorinated water (but this is not significant to remove traces of fecal contamination). Contact with public health authorities in states where implicated lots of strawberries had been distributed elicited no reports of unexplained food-borne outbreaks of hepatitis A in 1988-90. No outbreaks in the strawberry field workers had been reported.D.W. FitzSimons
KW  - Food
KW  - foodborne diseases
KW  - hepatitis
KW  - hepatitis A
KW  - strawberries
KW  - Georgia
KW  - USA
KW  - Fragaria
KW  - viruses
KW  - Rosaceae
KW  - Rosales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southeastern States of USA
KW  - America (North)
KW  - United States of America
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021185&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neutrophil oxidative burst in response to blastoconidia and pseudohyphae of Candida albicans: augmentation by granulocyte colony-stimulating factor and interferon-γ.
AU  - Roilides, E.
AU  - Uhlig, K.
AU  - Venzon, D.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1992///
VL  - 166
IS  - 3
SP  - 668
EP  - 673
SN  - 0022-1899
AD  - Roilides, E.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931251086.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The effects of granulocyte colony-stimulating factor (G-CSF) and interferon-γ (IFN-γ) on the oxidative burst of neutrophils (PMNL) in response to blastoconidia and pseudohyphae of C. albicans were assessed and compared with those in response to N-FMLP. G-CSF enhanced oxidative burst, as measured by superoxide production, in response to both FMLP and opsonized blastoconidia. The enhancement of oxidative burst in response to FMLP was significantly greater (P=0.004) than that in response to blastoconidia (65 and 39%, respectively). G-CSF also enhanced oxidative burst in response to pseudohyphae. IFN-γ enhanced oxidative burst in response to FMLP and opsonized blastoconidia by 53 and 50%, respectively. Moreover, IFN-γ significantly enhanced oxidative burst in response to opsonized and non-opsonized hyphae by 86 and 65%, respectively. It is concluded that G-CSF and IFN-γ enhance the oxidative burst of PMNL in response to both blastoconidia and pseudohyphae of C. albicans and an immunomodulatory role of the 2 cytokines in the host defences against this fungus is suggested.
KW  - cytokines
KW  - immunology
KW  - neutrophils
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251086&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human herpesvirus 7 (HHV-7) strain JI: independent confirmation of HHV-7.
AU  - Berneman, Z. N.
AU  - Gallo, R. C.
AU  - et al.
AU  - Ablashi, D. V. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1992///
VL  - 166
IS  - 3
SP  - 690
EP  - 691
SN  - 0022-1899
AD  - Berneman, Z. N.: Laboratory of Tumour Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021204.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - detection
KW  - strains
KW  - human herpesvirus 7
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - JI
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021204&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A zinc finger protein from Candida albicans is involved in sucrose utilization.
AU  - Kelly, R.
AU  - Kwon-Chung, K. J.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1992///
VL  - 174
IS  - 1
SP  - 222
EP  - 232
SN  - 0021-9193
AD  - Kelly, R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921210980.  Publication Type: Journal Article.  Language: English.  Number of References: 61 ref. Registry Number: 9001-42-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - A sucrose-inducible α-glucosidase activity that hydrolyzes sucrose in C. albicans was demonstrated previously. The enzyme is assayable in whole cells and was inhibited by both sucrose and maltose. A C. albicans gene (CASUC1) that affects sucrose utilization and α-glucosidase activity was cloned by expression in a Saccharomyces cerevisiae suc2 mutant (2102) devoid of invertase genes. CASUC1 enabled the S. cerevisiae mutant to utilize both sucrose and maltose. DNA sequence analysis revealed that CASUC1 encodes a putative zinc finger-containing protein with 28% identity to a maltose-regulatory gene (MAL63) of S. cerevisiae. The gene products of CASUC1 and MAL63 are approximately the same size (501 and 470 amino acids, respectively), and each contains a single zinc finger located at the N terminus. The zinc fingers of CASUC1 and MAL63 comprise 6 conserved cysteines (C6 zinc finger) and are of the general form Cys-Xaa2-Cys-Xaa6-Cys-Xaavariable-Cys-Xaa2-Cys-Xaa6-Cys (where Xaanindicates a stretch of the indicated number of any amino acids). Both contain 5 amino acids in the variable region. CASUC1 also complemented the maltose utilization defect of an S. cerevisiae mutant (TCY-137) containing a defined mutation in a maltose-regulatory gene. The sucrose utilization defect of type II C. stellatoidea, a sucrase-negative mutant of C. albicans, was corrected by CASUC1. Determinations of α-glucosidase activity in whole cells revealed that activity was restored in transformants cultivated on either sucrose or maltose.
KW  - alpha-glucosidase
KW  - enzymes
KW  - genes
KW  - genetics
KW  - physiology
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - alpha-D-glucosidase
KW  - fungus
KW  - Hyphomycetes
KW  - maltase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921210980&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phylogenetic analysis of the genus Borrelia: a comparison of North American and European isolates of Borrelia burgdorferi.
AU  - Marconi, R. T.
AU  - Garon, C. F.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1992///
VL  - 174
IS  - 1
SP  - 241
EP  - 244
SN  - 0021-9193
AD  - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515924.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - The 16S rRNA molecules from 4 species of Borrelia and from 6 isolates of B. burgdorferi were sequenced via the reverse transcriptase primer extension method. The sequences were aligned and evolutionary relationships were determined, including the calculation of evolutionary distances and the construction of a phylogenetic tree. These analyses demonstrate significant divergence among B. burgdorferi isolates, with the European isolates G1 and G2 (from man in Germany) residing most distant from the main cluster. Signature nucleotides which distinguish B. burgdorferi from all other members of this genus and which distinguish the European isolates G1 and G2 from the North American isolates B31, Sh-2-82 (both from Ixodes dammini [I. scapularis] in New York) and 1352 (from Amblyomma americanum in Texas) were identified. Finally, Southern blot analyses were performed to compare the restriction patterns of the genes coding for rRNA and to relate the data to the grouping scheme of D. Postic et al. (1990) [see Research in Microbiology, 141: 465-475].
KW  - DNA
KW  - molecular genetics
KW  - Nucleotide sequences
KW  - phylogeny
KW  - Ribosomal RNA
KW  - taxonomy
KW  - Europe
KW  - France
KW  - Germany
KW  - New York
KW  - North America
KW  - Texas
KW  - USA
KW  - Borrelia anserina
KW  - Borrelia burgdorferi
KW  - Borrelia coriaceae
KW  - Borrelia hermsii
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - North America
KW  - America
KW  - Great Plains States of USA
KW  - Gulf States of USA
KW  - Southern Plains States of USA
KW  - West South Central States of USA
KW  - Southern States of USA
KW  - Southwestern States of USA
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - rRNA
KW  - systematics
KW  - United States of America
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515924&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and characterization of a Candida albicans maltase gene involved in sucrose utilization.
AU  - Geber, A.
AU  - Williamson, P. R.
AU  - Rex, J. H.
AU  - Sweeney, E. C.
AU  - Bennett, J. E.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1992///
VL  - 174
IS  - 21
SP  - 6992
EP  - 6996
SN  - 0021-9193
AD  - Geber, A.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921213302.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 57-50-1.  Subject Subsets: Human Nutrition; Medical & Veterinary Mycology; Sugar Industry
N2  - In order to isolate the structural gene involved in sucrose utilization, a sucrose-induced C. albicans cDNA library was screened for clones expressing α-glucosidase activity. The C. albicans maltase structural gene (CAMAL2) was isolated. No other clones expressing α-glucosidase activity were detected. A genomic CAMAL2 clone was obtained by screening a size-selected genomic library with the cDNA clone. DNA sequence analysis revealed that CAMAL2 encodes a 570-amino-acid protein which shares 50% identity with the maltase structural gene (MAL62) of Saccharomyces carlsbergensis. The substrate specificity of the recombinant protein purified from Escherichia coli identified the enzyme as a maltase. Northern (RNA) analysis revealed that transcription of CAMAL2 is induced by maltose and sucrose and repressed by glucose. It is suggested that assimilation of sucrose in C. albicans relies on an inducible maltase enzyme. It is concluded that the family of genes controlling sucrose utilization in C. albicans shares similarities with the MAL gene family of S. cerevisiae and provides a model system for studying gene regulation in this pathogenic yeast.
KW  - genes
KW  - genetics
KW  - Sucrose
KW  - uptake mechanisms
KW  - yeasts
KW  - Candida albicans
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungus
KW  - Hyphomycetes
KW  - saccharose
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Sugar and Sugar Products (QQ020) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921213302&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Developmentally regulated infectivity of malaria sporozoites for mosquito salivary glands and the vertebrate host.
AU  - Touray, M. G.
AU  - Warburg, A.
AU  - Laughinghouse, A.
AU  - Krettli, A. U.
AU  - Miller, L. H.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1992///
VL  - 175
IS  - 6
SP  - 1607
EP  - 1612
SN  - 0022-1007
AD  - Touray, M. G.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920881365.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2  - An in vivo assay was developed for mosquito salivary gland invasion by preparing Plasmodium gallinaceum sporozoites from infected Aedes aegypti mosquitoes under physiological conditions and inoculating them into uninfected female A. aegypti. Sporozoites from mature oocysts were isolated from mosquito abdomens 10 or 11 days after an infective blood meal. Salivary gland sporozoites were isolated 13 or 14 days after an infective blood meal. Purified oocyst sporozoites that were inoculated into uninfected female mosquitoes invaded their salivary glands. Using the same assay system, sporozoites derived from salivary glands did not reinvade the salivary glands after inoculation. Conversely, as few as 10 to 50 salivary gland sporozoites induced infection in chickens, while only 2 of 10 chickens inoculated with 5000 oocyst sporozoites were infected. Both sporozoite populations were found to express a circumsporozoite protein on the sporozoite surface as determined by immunofluorescence assay and circumsporozoite precipitation test using a circumsporozoite protein-specific monoclonal antibody. It is concluded that molecules other than this circumsporozoite protein may be responsible for the differential invasion of mosquito salivary glands or infection of the vertebrate host.
KW  - developmental stages
KW  - disease vectors
KW  - immunology
KW  - infection
KW  - infectivity
KW  - livestock
KW  - parasites
KW  - poultry
KW  - salivary glands
KW  - sporozoites
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - fowls
KW  - Phasianidae
KW  - Plasmodiidae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Gallus gallus
KW  - Gallus
KW  - Phasianidae
KW  - Galliformes
KW  - birds
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - chickens
KW  - domesticated birds
KW  - growth phase
KW  - mosquitoes
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881365&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interferon γ induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells.
AU  - Biswas, P.
AU  - Poli, G.
AU  - et al.
AU  - Kinter, A. L. (
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1992///
VL  - 176
IS  - 3
SP  - 739
EP  - 750
SN  - 0022-1007
AD  - Biswas, P.: (G. Poli) Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Building 10, Room 11B-13, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942021076.  Publication Type: Journal Article.  Language: English. 
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - Pathogenesis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942021076&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.
AU  - Rawlings, D. J.
AU  - Kaslow, D. C.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1992///
VL  - 176
IS  - 5
SP  - 1483
EP  - 1487
SN  - 0022-1007
AD  - Rawlings, D. J.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930803435.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Immune responses in major histocompatibility complex (MHC)-disparate congenic mouse strains immunized with sexual stage malaria parasites or purified recombinant protein were adjuvant dependent. Whereas mice exhibited a limited antibody response to immunization with newly emerged Plasmodium falciparum gametes in Freund's adjuvant, all 5 congenic mouse strains responded to several transmission-blocking vaccine candidate antigens, when parasites were emulsified in a monophosphoryl lipid A (MPL) and trehalose dimycolate (TDM) adjuvant. The humoral response in those animals immunized with the antigen in a MPL/TDM adjuvant was helper T cell dependent, as evident by boosting of the antibody response after a 2nd immunization. If the immunogen consisted of purified recombinant protein, then the immune response was not MHC class II limited in mice immunized with either complete Freund's adjuvant or TDM/MPL. The potential role of adjuvants in overcoming apparent immune nonresponsiveness and the implications for development of a malaria transmission-blocking vaccine are discussed.
KW  - Adjuvants
KW  - Disease models
KW  - Experimental infections
KW  - Human diseases
KW  - immune response
KW  - immunization
KW  - Laboratory animals
KW  - Major histocompatibility complex
KW  - malaria
KW  - parasites
KW  - T lymphocytes
KW  - vaccines
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - falciparum malaria
KW  - histocompatibility complex
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - transmission-blocking vaccine antigens
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930803435&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The major capsular polysaccharide of Cryptococcus neoformans serotype B.
AU  - Bhattacharjee, A. K.
AU  - Kwon-Chung, K. J.
AU  - Glaudemans, C. P. J.
JO  - Carbohydrate Research
JF  - Carbohydrate Research
Y1  - 1992///
VL  - 233
SP  - 271
EP  - 272
SN  - 0008-6215
AD  - Bhattacharjee, A. K.: C. P. J. Glaudemans, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200275.  Publication Type: Journal Article.  Language: English.  Number of References: 2 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A recent reinvestigation of the major capsular polysaccharide of C. neoformans serotype B using 1H, 13C NMR and methylation analysis [Turner, S. H.; Cherniak, R. Carbohydrate Research (1991) 211, 103-116] confirmed the originally proposed structure [Bhattacharjee, A. K. (et al.) Carbohydrate Research (1980) 82, 103-111] and stated that the original research paper had presented 2 conflicting sets of methylation data. The authors reply that only a single set of data was displayed for linkage of GlcpA residues.
KW  - biochemistry
KW  - polysaccharides
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - capsule
KW  - complex carbohydrates
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200275&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut.
AU  - Pimenta, P. F. P.
AU  - Turco, S. J.
AU  - McConville, M. J.
AU  - Lawyer, P. G.
AU  - Perkins, P. V.
AU  - Sacks, D. L.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1992///
VL  - 256
IS  - 5065
SP  - 1812
EP  - 1815
SN  - 0036-8075
AD  - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930518213.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Adhesion of L. major promastigotes to the midgut epithelial cells of Phlebotomus papatasi was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific development modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes.
KW  - Development
KW  - developmental stages
KW  - Disease vectors
KW  - Host parasite relationships
KW  - human diseases
KW  - infections
KW  - Midgut
KW  - parasites
KW  - Promastigotes
KW  - Diptera
KW  - Leishmania major
KW  - Phlebotominae
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Psychodidae
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - growth phase
KW  - Lipophosphoglycan
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518213&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The challenge of malaria.
AU  - Miller, L. H.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1992///
VL  - 257
IS  - 5066
SP  - 36
EP  - 37
SN  - 0036-8075
AD  - Miller, L. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804233.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Research priorities for control and eradication of malaria are outlined, including the development of vaccines against both the erythrocytic parasite and sporozoite. The elimination of the vector offers another approach for eradication of Plasmodium falciparum and it is suggested that the introduction of genes which kill the parasite or block parasite development may alter the capacity of mosquitoes to transmit malaria. The identification of biochemical pathways and enzymes unique to the parasite, such as the polymerase involved in haemoglobin digestion, may provide targets for drug design.
KW  - control
KW  - Disease control
KW  - Disease vectors
KW  - Human diseases
KW  - Malaria
KW  - parasites
KW  - Research
KW  - Vaccines
KW  - Anopheles
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium
KW  - General account
KW  - mosquitoes
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Research (AA500) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Aquatic Biology and Ecology (MM300) 
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Regulation of glycogen metabolism in canine myocardium: effects of insulin and epinephrine in vivo.
AU  - Laughlin, M. R.
AU  - Taylor, J. F.
AU  - Chesnick, A. S.
AU  - Balaban, R. S.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1992///
VL  - 262
IS  - 6
SP  - E875
EP  - E883
SN  - 0002-9513
AD  - Laughlin, M. R.: Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19921453074.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 51-43-4, 9005-79-2, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Myocardial glycogen synthesis and glucose, lactate and oxygen extraction were estimated in the hearts of anaesthetized dogs during infusion of insulin and epinephrine. Glycogen synthesis was observed during a venous infusion of insulin and the newly synthesized glycogen was neither broken down nor was more glycogen synthesized during a subsequent epinephrine infusion. During recovery from epinephrine, glycogen synthesis took place at 2.1 times the rate seen in the control period. Glycogen synthesis was not stimulated in the absence of epinephrine by control infusions of saline. Glucose uptake was increased by insulin during the control period, so that the combined extraction of glucose and lactate exceeded the requirement for oxidizable substrate calculated form O2 consumption. The "excess" glucose is presumably available for glycogen synthesis. During recovery from epinephrine, lactate uptake was increased more than 3-fold. Since this additional lactate supplied most of the fuel required for oxidation, the excess glucose available for glycogen synthesis during this period was twice that seen before epinephrine. The data suggest that glycogen synthesis can be activated in the heart without an accompanying increase in glucose uptake by providing an alternative substrate (i.e. lactate) for oxidation.
KW  - epinephrine
KW  - Glycogen
KW  - heart
KW  - infusion
KW  - insulin
KW  - metabolism
KW  - dogs
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adrenaline
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921453074&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum.
AU  - Rawlings, D. J.
AU  - Kaslow, D. C.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 6
SP  - 3976
EP  - 3982
SN  - 0021-9258
AD  - Rawlings, D. J.: D.C. Kaslow, Bldg. 4, Room B1-37, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878981.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A 40 000 MW sexual stage radiolabelled surface protein of P. falciparum, Pfs40, was previously identified as a potential target antigen of transmission blocking immunity by an immunogenetic approach. Synthetic oligonucleotide "guessmers", based on micro-sequenced tryptic peptides of Pfs40 purified by 2 dimensional gel electrophoresis, were used to clone the full length cDNA and genomic DNA encoding Pfs40. The deduced amino acid sequence predicted an integral membrane protein containing 5 EF-hand calcium-binding domains. The biological activity of one or more of these domains was confirmed by binding of 45Ca to both native and recombinant Pfs40. Antisera to recombinant Pfs40 immunoprecipitated the native radiolabelled 40 000 MW surface protein. The predicted noncytosolic membrane-associated localization of Pfs40 is unique within the EF-hand calcium-binding protein superfamily.
KW  - Biochemistry
KW  - Calcium binding proteins
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - proteins
KW  - surface antigens
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - 40-kDa
KW  - biochemical genetics
KW  - DNA sequences
KW  - EF-hand calcium binding membrane
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preparation of a phospholipid-insensitive, Autophosphorylation-activated catalytic fragment of Acanthamoeba myosin I heavy chain kinase.
AU  - Brzeska, H.
AU  - Martin, B.
AU  - Kulesza-Lipka, D.
AU  - Baines, I.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 7
SP  - 4949
EP  - 4956
SN  - 0021-9258
AD  - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920878364.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Protozoology
N2  - It was shown that chymotryptic digestion of the Myosin I heavy chain kinase of A. castellanii produces a 54 000 MW fragment which contains 3 to 4 of the ~11 original phosphorylation sites and whose activity is greatly stimulated by autophosphorylation. However, both the rate of autophosphorylation and the kinase activity of the 54 000 MW fragment were independent of phospholipid and comparable to those of intact kinase in the presence of phospholipid. It is implied that the (probably NH2-terminal) region(s) removed by proteolysis is necessary for phospholipid-sensitive inhibition of autophosphorylation of sites residing within the (probably COOH-terminal) 54 000 MW fragment. The 54 000 MW fragment is reported to contain the catalytic site of the kinase as well as 3 to 4 sites whose phosphorylation is necessary for full expression of kinase activity. It was found that the middle region of the kinase molecule contains proline-rich regions that are similar to the COOH-terminal tail of the kinase substrate, Acanthamoeba myosin I.
KW  - Amoebiasis
KW  - Biochemistry
KW  - enzymes
KW  - Human diseases
KW  - Kinases
KW  - MYOSINS
KW  - parasites
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - amebiasis
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878364&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current perspective on Lyme disease.
AU  - Kaslow, R. A.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1992///
VL  - 267
IS  - 10
SP  - 1381
EP  - 1383
SN  - 0098-7484
AD  - Kaslow, R. A.: Epidemiology and Biometry Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930882289.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - In this article, a selected case of Borrelia burgdorferi in a 29-year-old woman from Maryland, USA, is presented, before a review of the current state of our knowledge concerning Lyme disease is discussed. The case selected is mild and typical, but fulfills the surveillance case definition. It is suggested that the rising numbers of reported cases may be disturbing indications that the ecology of Lyme disease is more diverse than was at first appreciated.
KW  - case reports
KW  - diagnosis
KW  - epidemiology
KW  - human diseases
KW  - Lyme disease
KW  - reviews
KW  - symptoms
KW  - therapy
KW  - Maryland
KW  - USA
KW  - Borrelia burgdorferi
KW  - man
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - lyme borreliosis
KW  - therapeutics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930882289&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Guanine nucleotide-binding proteins in the intestinal parasite Giardia lamblia. Isolation of a gene encoding an ~20-kDa ADP-ribosylation factor.
AU  - Murtagh, J. J., Jr.
AU  - Mowatt, M. R.
AU  - Lee, C. M.
AU  - Lee, F. J. S.
AU  - Mishima, K.
AU  - Nash, T. E.
AU  - Moss, J.
AU  - Vaughan, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 14
SP  - 9654
EP  - 9662
SN  - 0021-9258
AD  - Murtagh, J. J., Jr.: M. Vaughan, Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10/5N307, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920879866.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 73-40-5.  Subject Subsets: Protozoology
N2  - To determine whether genes for guanine nucleotide-binding proteins are present in G. lamblia [G. duodenalis] genomic DNA and cDNA libraries were screened by polymerase chain reaction and by hybridization with mixed oligonucleotide probes complementary to sequences encoding conserved GTP-binding domains. A gene with a high degree of sequence identity with mammalian ADP-ribosylation factors (ARFs), believed to be important in vesicular transport, was identified. The Giardia ARF gene had a 573-base open reading frame encoding 191 amino acids which are 63-70% identical with known mammalian and yeast ARFs. Sequence conservation among ARFs was greatest in putative GTP-binding domains. A single ARF mRNA species of ~ 750 bases was found in 2 different Giardia isolates. Primer extension and RNA sequencing of the Giardia ARF transcript revealed a short (6-base) 5′-untranslated region similar in size to those found in other Giardia transcripts. Giardia extracts contained ARF activity as shown by stimulation of cholera toxin-catalyzed ADP-ribosylation and a Giardia ARF expressed in Escherichia coli as a fusion protein likewise exhibited biochemical activity. Its presence in Giardia is consistent with the view that ARF emerged before the divergence of this protozoan from other eukaryotes (~ 1.5 billion years ago), and that an ARF-like protein may have been the ancestor of several other classes of signal-transducing guanine nucleotide-binding proteins, including the α subunits of the heterotrimeric G proteins.
KW  - Biochemistry
KW  - Biotechnology
KW  - DNA sequencing
KW  - genes
KW  - Guanine
KW  - Human diseases
KW  - nucleotide sequences
KW  - Nucleotides
KW  - parasites
KW  - proteins
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - DNA sequences
KW  - GIARDIA LAMBLIA
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of the actin-activated ATPase and in vitro motility activities of monomeric and filamentous Acanthamoeba myosin II.
AU  - Ganguly, C.
AU  - Baines, I. C.
AU  - Korn, E. D.
AU  - Sellers, J.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 29
SP  - 20900
EP  - 20904
SN  - 0021-9258
AD  - Ganguly, C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808556.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 9000-83-3.  Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activities of Acanthamoeba monomeric dephosphorylated and phosphorylated myosin II were found to be the same as the activity of filamentous dephosphorylated myosin II. The results support the conclusion that phosphorylation regulates filamentous myosin II by affecting filament conformation. Consistent with their equivalent enzymatic activities, monomeric and filamentous dephosphorylated myosin II were equally active in an in vitro motility assay in which myosin adsorbed to a surface drives the movement of F-actin. In contrast to their very different enzymatic activities, however, filamentous and monomeric phosphorylated myosin II had similar activities in the in vitro motility assay; both were much less active than monomeric and filamentous dephosphorylated myosin II. It is thought that the rate-limiting steps in the 2 assays are different and that, while the rate-limiting step for actin-activated Mg2+-ATPase activity is regulated only at the level of the filament, the rate-limiting step for motility can also be regulated at the level of the monomer.
KW  - adenosinetriphosphatase
KW  - biochemistry
KW  - enzymes
KW  - human diseases
KW  - motility
KW  - myosins
KW  - parasites
KW  - physiology
KW  - proteins
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - ATPase
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808556&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Limited proteolysis reveals a structural difference in the globular head domains of dephosphorylated and phosphorylated Acanthamoeba myosin II.
AU  - Ganguly, C.
AU  - Martin, B.
AU  - Bubb, M.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 29
SP  - 20905
EP  - 20908
SN  - 0021-9258
AD  - Ganguly, C.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808557.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology
N2  - Phosphorylation at 3 sites at the tip of the tail of myosin II from Acanthamoeba castellanii inactivates the actin-activated Mg2+-ATPase activity of filamentous myosin and the in vitro motility activity of both monomeric and filamentous myosin. To seek a structural explanation for these effects, susceptibilities of dephosphorylated and phosphorylated myosins II to endoproteinases were examined. Endoproteinase Arg-C cleaved myosin II preferentially at 2 sites in the globular head, Lys-621 and Arg-638, producing an NH2-terminal fragment of about 67 000 MW and a COOH-terminal fragment of about 112 000 MW. Dephosphorylated monomers and filaments were cleaved about 3 times more rapidly than their phosphorylated counterparts principally because of a much greater rate of cleavage at Arg-638; the ratio of cleavage at Arg-638:Lys-621 was about 3 for dephosphorylated myosins and about 0.5 for phosphorylated myosins. The data demonstrate that phosphorylation at the tip of the tail of Acanthamoeba myosin II causes a conformational change in the globular head that contains the catalytic sites; this conformational change is thought to be related to the different catalytic and motile activities of the dephosphorylated and phosphorylated enzymes.
KW  - motility
KW  - myosins
KW  - parasites
KW  - phosphorylation
KW  - physiology
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808557&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of Acanthamoeba myosin I heavy chain kinase by Ca2+-calmodulin.
AU  - Brzeska, H.
AU  - Kulesza-Lipka, D.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 33
SP  - 23870
EP  - 23875
SN  - 0021-9258
AD  - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804164.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref. Subject Subsets: Protozoology
N2  - It was shown that in Acanthamoeba Ca2+-calmodulin inhibits phospholipid-stimulated autophosphorylation of myosin I heavy chain kinase and also inhibits the catalytic activity of unphosphorylated kinase in the presence of phospholipid. Ca2+-calmodulin does not inhibit kinase activity in the absence of phospholipid. Micromolar Ca2+-calmodulin also inhibits binding of myosin I heavy chain kinase to phospholipid vesicles and purified plasma membranes. Proteolytic removal of a 7000 MW NH2-terminal segment from the 97 000 MW kinase prevents binding of both calmodulin and phospholipid; it is proposed that they bind to the same or overlapping sites. These data provide a mechanism by which Ca2+ could inhibit the actin-activated Mg2+-ATPase activity of the myosin I isozymes in vivo and regulate myosin I-dependent motile activities.
KW  - Biochemistry
KW  - enzymes
KW  - Human diseases
KW  - Kinases
KW  - MYOSINS
KW  - parasites
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804164&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae.
AU  - Lee, F. J. S.
AU  - Moss, J.
AU  - Vaughan, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 34
SP  - 24441
EP  - 24445
SN  - 0021-9258
AD  - Lee, F. J. S.: Laboratory of Cellular Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806703.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Protozoology
N2  - The 2 yeast ADP-ribosylation factors (ARFs) (~20 000 MW guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin in vitro) are &gt;60% identical to mammalian ARFs and are essential for cell viability. Although they are 96% identical in amino acid sequence, the yeast ARF1 gene is constitutively expressed, whereas the ARF2 gene is repressed by glucose. Human ARF5 and ARF6 and a Giardia ARF differ substantially in size and amino acid identity from other mammalian and eukaryotic ARFs but will activate cholera toxin. Expression of human ARF5, ARF6, or Giardia ARF cDNA rescued the lethal yeast ARF double mutant (arf1, arf2). Strains rescued by human ARF5, ARF6 or Giardia ARF grew much more slowly than wild-type yeast or strains rescued with yeast ARF1. It is inferred from the impaired growth of these rescued strains that the homologous ARFs may have specific targeting information that does not interact effectively or efficiently with the yeast protein membrane trafficking system.
KW  - Genes
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - Giardia
KW  - Hexamitidae
KW  - protozoa
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Sarcomastigophora
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - ADP-ribosylation factors
KW  - biochemical genetics
KW  - DNA sequences
KW  - fungus
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806703&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.
AU  - Tang, C. K.
AU  - Chin, J.
AU  - Harford, J. B.
AU  - Klausner, R. D.
AU  - Rouault, T. A.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1992///
VL  - 267
IS  - 34
SP  - 24466
EP  - 24470
SN  - 0021-9258
AD  - Tang, C. K.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19931465978.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 7439-89-6.  Subject Subsets: Human Nutrition
N2  - The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these 2 proteins involved in cellular Fe homeostasis. The activity of IRE-BP is itself regulated by Fe so that when cells are treated with an Fe source, the recombinant human IRE-BP in murine cells and the expressions of the endogenous IRE-BP of human and rabbit cells were examined. In all cases, Fe down-modulated the RNA binding activity of the IRE-BP, but in no instance was this decrease in activity accompanied by a decrease in the concentration of the protein as judged by quantitative Western blots. Moreover, the rate of synthesis of the IRE-BP and its rate of degradation have been found to be unaltered by Fe manipulation of cells in culture. Consistent with IRE-BP regulation occurring post-translationally, the Fe regulation of its activity was found to be unaffected by cycloheximide. The data are discussed in terms of a model of IRE-BP regulation involving the modification of the protein's Fe-sulfur centre.
KW  - binding proteins
KW  - cell cultures
KW  - Gene expression
KW  - Homeostasis
KW  - Iron
KW  - Man
KW  - Rabbits
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - carrier proteins
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465978&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fatty acid radical formation in rats administered oxidized fatty acids: in vivo spin trapping investigation.
AU  - Chamulitrat, W.
AU  - Jordan, S. J.
AU  - Mason, R. P.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1992///
VL  - 299
IS  - 2
SP  - 361
EP  - 367
SN  - 0003-9861
AD  - Chamulitrat, W.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institute of Health, PO Box 12233, Research Triangle Park, North Crolina 27709, USA.
N1  - Accession Number: 19951401111.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Animal Nutrition; Human Nutrition
N2  - Evidence is reported for fatty acid-derived free radical metabolite formation in the bile of male Sprague-Dawley rats dosed with spin traps and oxidized polyunsaturated fatty acids.
KW  - bile
KW  - fatty acids
KW  - free radicals
KW  - in vitro
KW  - lipid peroxidation
KW  - polyenoic fatty acids
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gall
KW  - polyunsaturated fatty acids
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401111&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis.
AU  - Jacobson, M. A.
AU  - Besch, C. L.
AU  - Child, C.
AU  - Hafner, R.
AU  - Matts, J. P.
AU  - Muth, K.
AU  - Wentworth, D. N.
AU  - Deyton, L.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1992///
VL  - 339
IS  - 8789
SP  - 333
EP  - 334
SN  - 0140-6736
AD  - Jacobson, M. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806939.  Publication Type: Journal Article.  Corporate Author: Community Programs for Clinical Research on AIDS Language: English.  Number of References: 8 ref. Registry Number: 18323-44-9, 58-14-0.  Subject Subsets: Protozoology
N2  - A double-blind, placebo-controlled trial to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in patients infected with the human immunodeficiency virus (HIV) is reported. Interim analysis showed that clindamycin-treated patients were 4.4 times more likely to experience an adverse effect that necessitated withdrawal of the study drug than those who received placebo. Diarrhoea and rash were reported in 16 (31%) and 11 (21%), respectively, of 52 patients treated with clindamycin (300 mg twice/day) compared with 2 (6%) and none of the 32 placebo-treated patients.
KW  - acquired immune deficiency syndrome
KW  - adverse effects
KW  - antiprotozoal agents
KW  - clindamycin
KW  - clinical trials
KW  - encephalitis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - opportunistic infections
KW  - parasites
KW  - prophylaxis
KW  - pyrimethamine
KW  - toxicity
KW  - California
KW  - North America
KW  - USA
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - AIDS
KW  - encephalomyelitis
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Improved diagnosis of Pneumocystis carinii infection by polymerase chain reaction on induced sputum and blood.
AU  - Lipschik, G.
AU  - Gill, V. J.
AU  - Lundgren, J. D.
AU  - Andrawis, V. A.
AU  - Nelson, N. A.
AU  - Nielsen, J. O.
AU  - Ognibene, F. P.
AU  - Kovacs, J. A.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1992///
VL  - 340
IS  - 8813
SP  - 203
EP  - 206
SN  - 0140-6736
AD  - Lipschik, G.: Critical Care Medicine Department, Warren G. Magnuson Clinical Centre, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19920881648.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Protozoology
N2  - The sensitivity and specificity of two polymerase chain reaction (PCR) methods are compared with conventional staining methods for detection of Pneumocystis carinii in induced sputum, bronchoalveolar lavage fluid, and blood. A nested PCR method correctly identified the presence of P. carinii in 17 microbiologically confirmed sputum samples from HIV-positive and other immunocompromised patients. PCR with a single primer pair was 71% sensitive and 94% specific. The sensitivity of conventional staining methods was significantly less than that of nested PCR. In bronchoalveolar lavage fluid, neither PCR method was significantly better than conventional staining methods. The report suggests that nested PCR on induced sputum is more sensitive than conventional staining methods for the diagnosis of P. carinii pneumonia.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - blood
KW  - diagnosis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - polymerase chain reaction
KW  - sputum
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881648&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pathophysiology of obesity.
AU  - Ravussin, E.
AU  - Swinburn, B. A.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1992///
VL  - 340
IS  - 8816
SP  - 404
EP  - 408
SN  - 0140-6736
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541-A, Pheonix, Arizona 85016, USA.
N1  - Accession Number: 19921449243.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Human Nutrition
N2  - Pathophysiology of obesity is reviewed. Topics covered include genetic versus environmental aetiology, food intake, energy balance and expenditure, risk factors for weight gain, nutrient balance equations and some implications for treatment and prevention.
KW  - Obesity
KW  - physiopathology
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - pathophysiology
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921449243&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficacy of atovaquone in treatment of toxoplasmosis in patients with AIDS.
AU  - Kovacs, J. A.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1992///
VL  - 340
IS  - 8820
SP  - 637
EP  - 638
SN  - 0140-6736
AD  - Kovacs, J. A.: Critical Care Medicine Deopartment, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA.
N1  - Accession Number: 19920881621.  Publication Type: Journal Article.  Corporate Author: NIAID-Clinical Center Intramural AIDS Program Language: English.  Number of References: 10 ref. Registry Number: 95233-18-4.  Subject Subsets: Protozoology
N2  - Atovaquone (formerly 566C80) has been shown to exhibit potent activity against Toxoplasma gondii in vitro and in laboratory animals. Eight patients with AIDS and presumed or biopsy confirmed toxoplasmosis who were intolerant of or who had not responded to standard therapy were treated with oral atovaquone 750 mg 4 times/day. Seven patients showed radiographic improvement; the other remained radiographically stable. Six patients died 6-60 weeks after enrolment with no clinical (6) or necropsy (3) evidence of recurrent toxoplasmosis; 2 patients relapsed at 10 and 32 weeks. One patient required temporary discontinuation of the drug due to a rash.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - adverse effects
KW  - atovaquone
KW  - central nervous system
KW  - drug therapy
KW  - ELISA
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - radiography
KW  - North America
KW  - USA
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - adverse reactions
KW  - AIDS
KW  - chemotherapy
KW  - CNS
KW  - enzyme linked immunosorbent assay
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881621&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - How chloroquine works.
AU  - Wellems, T. E.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1992///
VL  - 355
IS  - 6356
SP  - 108
EP  - 109
SN  - 0028-0836
AD  - Wellems, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803842.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 14875-96-8.  Subject Subsets: Protozoology
N2  - In this article, the work of Slater and Cerami (Nature (1992) 355, 167-169) is discussed. These authors have shown that chloroquine interferes with a haem detoxification enzyme (haem polymerase) that is essential for the survival of malaria parasites in erythrocytes. With chloroquine resistance, it is suggested that Plasmodium falciparum does not concentrate the drug to the high levels found in sensitive parasites, presumably keeping intravacuolar chloroquine levels below those that would inhibit haem polymerase. An efflux mechanism releases chloroquine from resistant parasites 40-50 times faster than from sensitive parasites. It is suggested that in haem polymerization, P. falciparum is demonstrating a vulnerable target that may prove extremely useful in the treatment of chloroquine resistance.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The mode of action of chloroquine is briefly discussed with particular reference to the paper by Stater and Cerami (Nature (London), (1992) 355 (6356), 167-169) which reports that chloroquine interferes with a haem detoxification enzyme that is essential to the survival of malaria parasites in red blood cells.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - chloroquine
KW  - drug resistance
KW  - enzyme activity
KW  - haem
KW  - human diseases
KW  - in vitro
KW  - malaria
KW  - mode of action
KW  - parasites
KW  - polymerization
KW  - Apicomplexa
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - heme
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803842&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Parasitizing the cytokine system.
AU  - Sher, A.
AU  - Amiri, P.\Locksley, R. M.\Parslow, T. G.\Sadick, M.\Rector, E.\Ritter, D.\McKerrow, J. H.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1992///
VL  - 356
IS  - 6370
SP  - 565
EP  - 566
SN  - 0028-0836
AD  - Sher, A.: Laboratory of Parasitic Diseases, NIH National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950806781.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 308079-78-9.  Subject Subsets: Helminthology
N2  - Following the letter by Amiri et al. (Nature (1992) 356, 604-607), it is suggested that the conventional view that schistosomal granulomas represent a dynamic outcome of different T lymphocyte, lymphokine and inflammatory cell responses must now be challenged. Amiri et al. showed that, in the absence of B and T lymphocytes, a single lymphokine, tumour necrosis factor α (TNFα), is sufficient to trigger egg-granuloma formation. They also suggested that Schistosoma uses host TNFα as a reproductive stimulus.
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - immune response
KW  - liver
KW  - lymphocytes
KW  - parasites
KW  - reproduction
KW  - tumour necrosis factor
KW  - mice
KW  - Schistosoma
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - cachectin
KW  - cachexin
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806781&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Production of anti-idiotypic antibodies as potential immunoreagents for the serological diagnosis of bovine cysticercosis.
AU  - Hayunga, E. G.
AU  - Sumner, M. P.
AU  - Duncan, J. F., Jr.
AU  - Chakrabarti, E. K.
AU  - Webert, D. W.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1992///
VL  - 653
SP  - 178
EP  - 183
SN  - 0077-8923
AD  - Hayunga, E. G.: Division of Research Grants, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806708.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Helminthology
N2  - This study aimed to demonstrate the feasibility of using anti-idiotypic antibodies as alternative immunoreagents for the serological diagnosis of bovine cysticercosis (Taenia saginata). Rabbits and mice were inoculated with a 12 000 MW fraction of Taenia hydatigena cyst fluid (ThFAS) to produce either polyclonal or monoclonal antibodies (idiotypes), respectively. IgG idiotypes were purified by preparative protein A column, then inoculated into other rabbits to produce anti-idiotypes. The presence of anti-idiotypes in hyperimmune serum was demonstrated by competitive inhibition ELISA. The anti-idiotypes were then purified and used as coating antigen in a plate ELISA; results were compared to those using ThFAS as coating antigen. The absorbance values for infection serum obtained using the anti-idiotype were less than those using the native antigen, but were nevertheless significantly different from the control. It is concluded that anti-idiotypes can be used as synthetic antigens for diagnostic purposes.
KW  - Antibodies
KW  - antigens
KW  - ELISA
KW  - helminths
KW  - idiotypes
KW  - immunodiagnosis
KW  - Livestock
KW  - metacestodes
KW  - parasites
KW  - Artiodactyla
KW  - Bovidae
KW  - cattle
KW  - Cestoda
KW  - Ruminants
KW  - Taenia hydatigena
KW  - Taenia saginata
KW  - Taeniidae
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ruminants
KW  - Artiodactyla
KW  - Bos
KW  - Bovidae
KW  - Platyhelminthes
KW  - invertebrates
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - antigenicity
KW  - enzyme linked immunosorbent assay
KW  - immunogens
KW  - parasitic worms
KW  - serological diagnosis
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806708&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid bioavailability in humans: ascorbic acid in plasma, serum, and urine.
AU  - Wang, Y. H.
AU  - Dhariwal, K. R.
AU  - Levine, M.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1992///
VL  - 669
SP  - 383
EP  - 386
SN  - 0077-8923
AD  - Wang, Y. H.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19931459880.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 7 ref. Registry Number: 50-81-7, 490-83-5.  Subject Subsets: Human Nutrition
KW  - Ascorbic acid
KW  - Binding proteins
KW  - blood
KW  - Dehydroascorbic acid
KW  - stability
KW  - urine
KW  - USA
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - carrier proteins
KW  - New views on the function and health effects of vitamins
KW  - United States of America
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459880&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Eicosanoids and health.
AU  - Lands, W. E. M.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1992///
VL  - 676
SP  - 46
EP  - 59
SN  - 0077-8923
AD  - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, Parklawn Building, Rm 16C-06, 5600 Fishers Lane, Rockville, Maryland 20857, USA.
N1  - Accession Number: 19931466969.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 44 ref. Subject Subsets: Human Nutrition
N2  - The role of eicosanoids as cellular mediators in health and cardiovascular diseases is reviewed including a discussion on the supply of n-6 and n-3 fatty acid precursors, dietary imbalances of these fatty acids and assessment of their nutritional status.
KW  - cardiovascular diseases
KW  - eicosanoids
KW  - health
KW  - polyenoic fatty acids
KW  - reviews
KW  - Japan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - polyunsaturated fatty acids
KW  - Third International Conference on Nutrition in Cardio-Cerebrovascular Diseases
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466969&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diet and cancer prevention: a National Cancer Institute priority.
AU  - Greenwald, P.
AU  - Clifford, C.
JO  - Vitamins and cancer prevention
JF  - Vitamins and cancer prevention
Y1  - 1992///
IS  - 3
SP  - 1
EP  - 22
CY  - Baton Rouge; USA
PB  - Louisiana State University Press
SN  - 0807117897
AD  - Greenwald, P.: Division of Cancer Prevention and Control, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402899.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - The main efforts of the National Cancer Institute (USA) since the 1970's in investigating the role of diet in cancer prevention are discussed.
KW  - carcinoma
KW  - diet
KW  - government organizations
KW  - neoplasms
KW  - prevention
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Vitamins and cancer prevention
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402899&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Oral isotretinoin is effective in the prevention of skin cancer in patients with xeroderma pigmentosum.
AU  - DiGiovanna, J. J.
AU  - Kraemer, K. H.
AU  - Peck, G. L.
AU  - Abangan, D. L.
JO  - Vitamins and cancer prevention
JF  - Vitamins and cancer prevention
Y1  - 1992///
IS  - 3
SP  - 188
EP  - 195
SN  - 0807117897
AD  - DiGiovanna, J. J.: Dermatology Branch, National Cancer Institute, National Institute of Health Building 10, Room 12N238, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402910.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 10 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - 5 patients with xeroderma pigmentosum were cleared of existing cancers and treated daily for 2 years with isotretinoin (a derivative of vitamin A) 2.0 mg/kg. Patients had a significant decrease in the number of new basal- and squamous-cell carcinomas. After treatment was discontinued however, the incidences of new skin cancers returned to pretreatment levels. In another study, it was investigated whether chemoprevention could be obtained with less toxicity. 7 patients were treated daily with isotretinoin 0.5 mg/kg. In most of these, the frequency of skin cancers decreased compared with periods of no treatment and toxicities were less frequent compared with the high-dose treatment. It is concluded that oral isotretinoin is effective in preventing skin cancer in patients with xeroderma pigmentosum with the lowest effective, least toxic dosage varying among patients.
KW  - carcinoma
KW  - derivatives
KW  - neoplasms
KW  - prevention
KW  - retinol
KW  - skin
KW  - skin diseases
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - cancers
KW  - dermatoses
KW  - dermis
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Vitamins and cancer prevention
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402910&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Does beta-carotene explain why reduced cancer risk is associated with vegetable and fruit intake? New research directions.
AU  - Ziegler, R. G.
AU  - Ursin, G.
AU  - Craft, N. E.
AU  - Subar, A. F.
AU  - Graubard, B. I.
AU  - Patterson, B. H.
JO  - Vitamins and cancer prevention
JF  - Vitamins and cancer prevention
Y1  - 1992///
IS  - 3
SP  - 352
EP  - 371
CY  - Baton Rouge; USA
PB  - Louisiana State University Press
SN  - 0807117897
AD  - Ziegler, R. G.: Epidemiology and Biostatisitcs Program, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, No. 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402922.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 51 ref. Registry Number: 7235-40-7.  Subject Subsets: Human Nutrition
N2  - This article reviews the relation between reduced cancer risk and β-carotene (provided by fruit and vegetables) intake. 3 approaches are used: data from the 1982-84 Epidemiologic Followup Study of the first National Health and Nutrition Examination Survey and the 1987 National Health Interview Study (USA) are used to examine which food groups correlate with fruit and vegetable intake; a liquid chromatographic method for the resolution of the common carotenoids in blood is presented; and a population-based case-control study of lung cancer among white men in New Jersey is discussed to assess whether intakes of individual carotenoids can produce strong inverse associations.
KW  - beta-carotene
KW  - carcinoma
KW  - diet studies
KW  - intake
KW  - prevention
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Vitamins and cancer prevention
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402922&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection.
AU  - Sher, A.
AU  - Gazzinelli, R. T.
AU  - Oswald, I. P.
AU  - Clerici, M.
AU  - Kullberg, M.
AU  - Pearce, E. J.
AU  - Berzofsky, J. A.
AU  - Mosmann, T. R.
AU  - James, S. L.
AU  - Morse, H. C., III
AU  - Shearer, G. M.
JO  - Immunological Reviews
JF  - Immunological Reviews
Y1  - 1992///
IS  - 127
SP  - 183
EP  - 204
SN  - 0105-2896
AD  - Sher, A.: Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804554.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref. Subject Subsets: Protozoology; Helminthology
N2  - Evidence for the Th2 immunoregulatory pathway and its possible functions in the immunosuppression accompanying parasitic (Leishmania, Trypanosoma cruzi, Toxoplasma gondii, Schistosoma mansoni) and retroviral infections are discussed.
KW  - Cytokines
KW  - helminths
KW  - immune response
KW  - Immunology
KW  - Parasites
KW  - reviews
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current status of HIV therapy: I. Antiretroviral agents.
AU  - Hoth, D. F., Jr.
AU  - Meyers, M. W.
AU  - Stein, D. S.
AU  - Feinberg, J.
JO  - Hospital Practice
JF  - Hospital Practice
Y1  - 1992///
IS  - Sept. 15
SP  - 145
EP  - 156
SN  - 0018-5809
AD  - Hoth, D. F., Jr.: Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19932022066.  Publication Type: Journal Article.  Language: English. 
N2  - Part II, concentrating on opportunistic diseases, follows in the same issue (J. Feinberg and D.F. Hoth Jr, pp. 161-174).
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - drug therapy
KW  - HIV infections
KW  - Opportunistic infections
KW  - AIDS
KW  - chemotherapy
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022066&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Developing drugs for the deep mycoses: a short history.
AU  - Bennett, J. E.
A2  - Bennett, J. E.
A2  - Hay, R. J.
A2  - Peterson, P. K.
T2  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
JO  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
JF  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
Y1  - 1992///
SP  - 3
EP  - 12
CY  - Edinburgh; UK
PB  - Churchill Livingstone
SN  - 0443046840
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19921212122.  Publication Type: Conference paper.  Language: English.  Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The history of the development of various antifungal agents, including amphotericin B, flucytosine and azoles, is discussed.
KW  - Antifungal agents
KW  - history
KW  - fungistats
KW  - New strategies in fungal disease
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212122&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Dietary assessment methods for macronutrients.
AU  - Hartman, A. M.
AU  - Block, G.
A2  - Micozzi, M. S.
A2  - Moon, T. E.
T2  - Macronutrients: investigating their role in cancer.
JO  - Macronutrients: investigating their role in cancer.
JF  - Macronutrients: investigating their role in cancer.
Y1  - 1992///
SP  - 87
EP  - 124
CY  - New York; USA
PB  - Marcel Dekker Inc.
SN  - 0824785932
AD  - Hartman, A. M.: Division of Cancer Prevention and Control, National Cancer Institute , National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19931460935.  Publication Type: Miscellaneous.  Language: English.  Number of References: 125 ref. Subject Subsets: Human Nutrition
N2  - Dietary assessment methods, their validity and the use and limitations of the type of data they produce are reviewed.
KW  - Diet study techniques
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460935&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Rapid identification of small supercoiled plasmids in cloned populations of Borrelia burgdorferi.
AU  - Schwan, T. G.
AU  - Schrumpf, M. E.
AU  - Karstens, R. H.
A2  - Munderloh, U.G.
A2  - Kurtti, T.J.
T2  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JO  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JF  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology and Minnesota Extension Service, Saint Paul, Minnesota, USA.
Y1  - 1992///
SP  - 89
EP  - 94
CY  - St Paul, Minnesota; USA
PB  - University of Minnesota
AD  - Schwan, T. G.: Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950506531.  Publication Type: Conference paper.  Language: English.  Number of References: 8 ref.
KW  - Lyme disease
KW  - molecular genetics
KW  - pathogens
KW  - plasmids
KW  - tickborne diseases
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506531&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Vector/spirochete relationships of arthropod-borne borrelioses.
AU  - Burgdorfer, W.
A2  - Munderloh, U.G.
A2  - Kurtti, T.J.
T2  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JO  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JF  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
Y1  - 1992///
SP  - 111
EP  - 120
CY  - St Paul, Minnesota; USA
PB  - University of Minnesota
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950506534.  Publication Type: Conference paper.  Language: English.  Number of References: 35 ref.
N2  - This paper includes a general table of arthropod-borne borrelioses, their vectors, reservoirs, distributions and disease names.
KW  - disease vectors
KW  - host parasite relationships
KW  - pathogens
KW  - reviews
KW  - tickborne diseases
KW  - Argasidae
KW  - Borrelia burgdorferi
KW  - Borrelia recurrentis
KW  - Ixodes persulcatus
KW  - Ixodes ricinus
KW  - Ixodidae
KW  - Ornithodoros
KW  - Pediculus humanus
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Argasidae
KW  - Pediculus
KW  - Pediculidae
KW  - Anoplura
KW  - Phthiraptera
KW  - insects
KW  - Hexapoda
KW  - bacterium
KW  - body louse
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506534&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Body fat distribution and breast cancer preliminary results from a case-control study in women from Southern Italy.
AU  - Borrelli, R.
AU  - De Filippo, E.
AU  - Scalfi, L.
AU  - Buglione, G.
AU  - Contaldo, F.
AU  - Marone, A.
AU  - Parisi, V.
AU  - Cremona, F.
AU  - Scognamiglio, F.
AU  - Palaia, R.
AU  - Ruffolo, F.
AU  - Salvatore, M.
A2  - Ailhaud, G.
A2  - Guy-Grand, B.
A2  - Lafontan, M.
A2  - Ricquier, D.
T2  - Obesity in Europe 91. Proceedings of the 3rd European Congress on Obesity.
JO  - Obesity in Europe 91. Proceedings of the 3rd European Congress on Obesity.
JF  - Obesity in Europe 91. Proceedings of the 3rd European Congress on Obesity.
Y1  - 1992///
SP  - 125
EP  - 128
CY  - London; UK
PB  - John Libbey & Company Ltd
SN  - 0861962737
AD  - Borrelli, R.: Clinical Nutrition, 2nd Medical School, University of Naples and National Cancer Institute (NCI), Naples, Italy.
N1  - Accession Number: 19921445280.  Publication Type: Conference paper.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - 115 women admitted to the National Cancer Institute, Naples, submitted to breast biopsy and anthropometry, and completed a dietary and life-style questionnaire. 82 were identified as having breast cancer and 33 benign breast disease (mastitis, fibrocystic disease, etc.). Body measurements included height; weight; skinfold thickness (biceps, triceps, suprailiac and subscapular); chest, waist, hip and arm circumference; body mass index (kg/m²); waist/hip ratio; subscapular/triceps skinfold thickness ratio. Women with breast cancer were bigger (as shown by greater circumferences) and had a more pronounced abdominal distribution of fat (higher waist/hip ratio) than women with benign breast disease. Skinfold thickness was greater in cancer patients but the difference only reached significance (P&lt;0.05) in the subscapular skinfold. It is concluded that body fat distribution could represent a risk factor not only for cardiovascular diseases but also for some female carcinomas, such as breast cancer.
KW  - body fat
KW  - Carcinoma
KW  - distribution
KW  - mammary glands
KW  - France
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - European Congress on Obesity
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445280&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Recent advances in the molecular genetics of Cryptococcus neoformans.
AU  - Kwon-Chung, K. J.
AU  - Edman, J. C.
A2  - Bennett, J. E.
A2  - Hay, R. J.
A2  - Peterson, P. K.
T2  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
JO  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
JF  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
Y1  - 1992///
SP  - 195
EP  - 207
CY  - Edinburgh; UK
PB  - Churchill Livingstone
SN  - 0443046840
AD  - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19921212132.  Publication Type: Conference paper.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Molecular biological studies with the emphasis on gene cloning, karyotyping, and the relationship between DNA-mediated transformation and virulence of C. neoformans are discussed.
KW  - genetics
KW  - molecular genetics
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - biochemical genetics
KW  - fungus
KW  - New strategies in fungal disease
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212132&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Energy intake and cancer.
AU  - Albanes, D.
A2  - Micozzi, M. S.
A2  - Moon, T. E.
T2  - Macronutrients: investigating their role in cancer.
JO  - Macronutrients: investigating their role in cancer.
JF  - Macronutrients: investigating their role in cancer.
Y1  - 1992///
SP  - 205
EP  - 229
CY  - New York; USA
PB  - Marcel Dekker Inc.
SN  - 0824785932
AD  - Albanes, D.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19931460944.  Publication Type: Miscellaneous.  Language: English.  Number of References: 125 ref. Subject Subsets: Human Nutrition
N2  - The relationship between energy intake and cancer is reviewed. Results from early studies on animals and later epidemiologic studies are included.
KW  - Carcinoma
KW  - energy intake
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460944&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Immunodiagnosis of invasive candidiasis in patients with neoplastic diseases.
AU  - Walsh, T. J.
AU  - Lee, J. W.
AU  - Pizzo, P. A.
A2  - Bennett, J. E.
A2  - Hay, R. J.
A2  - Peterson, P. K.
T2  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
JO  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
JF  - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991.
Y1  - 1992///
SP  - 227
EP  - 242
CY  - Edinburgh; UK
PB  - Churchill Livingstone
SN  - 0443046840
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19921212134.  Publication Type: Conference paper.  Language: English.  Number of References: 61 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Markers, including mannans, D-arabinitol, Candida enolase and Candida heat shock protein, are discussed as they pertain to invasive candidosis in patients with neoplastic diseases, paying particular attention to immunodiagnostic techniques.
KW  - diagnosis
KW  - immunological techniques
KW  - infections
KW  - neoplasms
KW  - predisposition
KW  - Candida
KW  - Man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - cancers
KW  - fungus
KW  - Hyphomycetes
KW  - New strategies in fungal disease
KW  - serological techniques
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212134&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - HIV interactions with some endemic diseases in Africa.
AU  - Williams, A. O.
A2  - Williams, A. O.
T2  - AIDS: an African perspective.
JO  - AIDS: an African perspective.
JF  - AIDS: an African perspective.
Y1  - 1992///
SP  - 233
EP  - 251
CY  - Boca Raton; USA
PB  - CRC Press Inc.
SN  - 084936437X
AD  - Williams, A. O.: National Institutes of Health, Fogarty International Center for Advanced Study, Bethesda, MD, USA.
N1  - Accession Number: 19930804462.  Publication Type: Miscellaneous.  Language: English.  Number of References: 145 ref. Subject Subsets: Protozoology; Helminthology
N2  - Some endemic infectious diseases and their interactions with HIV in sub-Saharan Africa, including malaria, tuberculosis and other myco-bacterial infections, leprosy, leishmaniasis, African trypanosomiasis, helminth infections, enteropathogens, hepatitis B, C and D viruses, and Epstein-Barr virus infections are discussed. It is highlighted that tuberculosis is frequently reactivated in HIV-infected individuals.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Helminths
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Interactions
KW  - Leishmaniasis
KW  - Malaria
KW  - Opportunistic infections
KW  - parasites
KW  - reviews
KW  - Trypanosomiasis
KW  - Africa
KW  - Apicomplexa
KW  - Leishmania
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - AIDS
KW  - human immunodeficiency virus
KW  - leishmaniosis
KW  - parasitic worms
KW  - trypanosomosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804462&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Transovarial transmission: an effective ecological means for the survival of tick-borne spotted fever group rickettsiae.
AU  - Burgdorfer, W.
A2  - Munderloh, U.G.
A2  - Kurtti, T.J.
T2  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JO  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JF  - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
Y1  - 1992///
SP  - 265
EP  - 272
CY  - St Paul, Minnesota; USA
PB  - University of Minnesota
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950506554.  Publication Type: Conference paper.  Language: English.  Number of References: 13 ref.
KW  - disease vectors
KW  - host parasite relationships
KW  - infections
KW  - pathogens
KW  - Rocky Mountain spotted fever
KW  - tickborne diseases
KW  - transovarial transmission
KW  - Dermacentor andersoni
KW  - Dermacentor variabilis
KW  - Rickettsia montanensis
KW  - Rickettsia rhipicephali
KW  - Rickettsia rickettsii
KW  - Dermacentor
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - parasite host relationships
KW  - Rickettsia montana
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Dietary fiber.
AU  - Lanza, E.
AU  - Shankar, S.
AU  - Trock, B.
A2  - Micozzi, M. S.
A2  - Moon, T. E.
T2  - Macronutrients: investigating their role in cancer.
JO  - Macronutrients: investigating their role in cancer.
JF  - Macronutrients: investigating their role in cancer.
Y1  - 1992///
SP  - 293
EP  - 319
CY  - New York; USA
PB  - Marcel Dekker Inc.
SN  - 0824785932
AD  - Lanza, E.: National Cancer Institute, National Institute of Health, Bethedsa, Maryland, USA.
N1  - Accession Number: 19931460948.  Publication Type: Miscellaneous.  Language: English.  Number of References: 98 ref. Subject Subsets: Human Nutrition
N2  - Evidence for the role of a fibre-rich diet in the prevention of certain types of cancers, especially colon and breast cancer, is reviewed.
KW  - Carcinoma
KW  - Diet
KW  - fibre
KW  - Neoplasms
KW  - prevention
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - fiber
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Survey of some Indian medicinal plants for receptor specific protein.
AU  - Bhupati Bhattacharya
AU  - Chakraborti, S. K.
A2  - Raychaudhuri, S. P.
T2  - Recent advances in medicinal, aromatic and spice crops (Volume 2). International conference held on 28-31 January 1989, at New Delhi, India.
JO  - Recent advances in medicinal, aromatic and spice crops (Volume 2). International conference held on 28-31 January 1989, at New Delhi, India.
JF  - Recent advances in medicinal, aromatic and spice crops (Volume 2). International conference held on 28-31 January 1989, at New Delhi, India.
Y1  - 1992///
SP  - 365
EP  - 369
CY  - New Delhi; India
PB  - Today & Tomorrow's Printers & Publishers
SN  - 8170194121\1555282660
AD  - Bhupati Bhattacharya: Department of Chemotherapy, Chittaranjan National Cancer Institute, 37 S. P. Mookerjee Road, Calcutta-700 026, India.
N1  - Accession Number: 19950312662.  Publication Type: Conference paper.  Language: English.  Number of References: 8 ref. Subject Subsets: Horticultural Science
N2  - Plant lectins (receptor specific proteins, RSP) were extracted from the seeds of 18 medicinal plants. Agglutination tests were carried out on tumour cells (Ehrlich ascites cells from mice; EAC), and antitumour activity was assessed in vitro and in vivo. Lectins extracted from Artocarpus integrifolia [A. integer] showed the highest level of agglutination (90%) with only 3 other species having any activity at all in this test (Citrullus vulgaris [C. lanatus], Syzygium cumini and Liquidambar chinensis [Altingia chinensis]). Populus alba showed an inhibitory effect on EAC tumour cells in vitro at a dose level of 2.5 mg/kg. Four species (Poinciana pulcherrima [Caesalpinia pulcherrima], Nyctanthes arbor-tristis, Mirabilis jalapa and Populus alba) showed in vivo antitumour activity (against EAC or S-180 in mice) as evidenced by T/C (treatment/control) mean survival time values &gt;125%.
KW  - antineoplastic properties
KW  - cytotoxicity
KW  - jackfruits
KW  - lectins
KW  - medicinal plants
KW  - pharmacology
KW  - seeds
KW  - surveys
KW  - watermelons
KW  - India
KW  - Artocarpus
KW  - Artocarpus heterophyllus
KW  - Artocarpus integer
KW  - Caesalpinia pulcherrima
KW  - Citrullus lanatus
KW  - mice
KW  - Mirabilis jalapa
KW  - Nyctanthes arbor-tristis
KW  - Populus alba
KW  - Syzygium cumini
KW  - Moraceae
KW  - Urticales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Artocarpus
KW  - Caesalpinia
KW  - Caesalpinioideae
KW  - Fabaceae
KW  - Fabales
KW  - Citrullus
KW  - Cucurbitaceae
KW  - Violales
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Mirabilis
KW  - Nyctaginaceae
KW  - Caryophyllales
KW  - Nyctanthes
KW  - Verbenaceae
KW  - Lamiales
KW  - Populus
KW  - Salicaceae
KW  - Salicales
KW  - Syzygium
KW  - Myrtaceae
KW  - Myrtales
KW  - Altingia
KW  - Hamamelidaceae
KW  - Hamamelidales
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - Altingia chinensis
KW  - anti-neoplastic properties
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Recent advances in medicinal, aromatic and spice crops
KW  - white poplar
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Non-wood Forest Products (KK540) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Fruit and vegetable consumption: national survey data.
AU  - Patterson, B. H.
AU  - Block, G.
A2  - Bendich, A.
A2  - Butterworth, C. E., Jr.
T2  - Micronutrients in health and in disease prevention.
JO  - Micronutrients in health and in disease prevention.
JF  - Micronutrients in health and in disease prevention.
Y1  - 1992///
SP  - 409
EP  - 436
CY  - New York; USA
PB  - Marcel Dekker
SN  - 0824785398
AD  - Patterson, B. H.: Division of Cancer Prevention and Control, Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19931462368.  Publication Type: Miscellaneous.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - US national survey data are reviewed in an effort to characterize the actual diet of adult Americans with respect to fruit and vegetables. The surveys used are the Second National Health and Nutrition Examination Survey; the Nationwide Food Consumption Survey; the Continuing Survey of Food Intakes by Individuals; and the Cancer Supplement of the National Health Interview.
KW  - consumption
KW  - diet studies
KW  - Foods
KW  - Fruit
KW  - reviews
KW  - Vegetables
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - vegetable crops
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - T-cell regulation of immediate hypersensitivity: lessons from helminth parasites and allergic diseases.
AU  - Nutman, T. B.
A2  - Moqbel, R.
T2  - Allergy and immunity to helminths: common mechanisms or divergent pathways.
Y1  - 1992///
CY  - London; UK
PB  - Taylor & Francis Ltd.
SN  - 0748400222
AD  - Nutman, T. B.: Laboratory of Parasitic Diseases, Building 4, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930807975.  Publication Type: Book chapter.  Language: English.  Number of References: 104 ref. Subject Subsets: Helminthology
N2  - The role of T-cells and their products in the regulation of immediate hypersensitivity responses is discussed with regard to: T-cell clones (virally-transformed T-cell clones, mitogen-driven T-cell clones, allergen-specific T-cell clones, parasite-specific T-cell clones); cytokine expression in parasitic infections and allergic diseases; the role of antigen structure; antigen presentation.
KW  - helminths
KW  - Human diseases
KW  - hypersensitivity
KW  - Immediate hypersensitivity
KW  - immune response
KW  - immunity
KW  - parasites
KW  - T lymphocytes
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - allergic responses
KW  - hypersensitiveness
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Systematics and ecology of the subgenus Ixodiopsis (Acari: Ixodidae: Ixodes).
AU  - Robbins, R. G.
AU  - Keirans, J. E.
T2  - Systematics and ecology of the subgenus Ixodiopsis (Acari: Ixodidae: Ixodes).
Y1  - 1992///
CY  - Lanham, Maryland; USA
PB  - Entomological Society of America
SN  - 0938522388
AD  - Robbins, R. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, c/o Department of Entomology, Museum Support Center, Smithsonian Institution, Washington, DC 20560, USA.
N1  - Accession Number: 19950503710.  Publication Type: Book.  Language: English.  Number of References: 16 pp. of ref. Subject Subsets: Medical & Veterinary Entomology
N2  - This monograph endeavours to: (1) summarize and evaluate previous observations on the morphology, hosts and distribution of each species in the Ixodes tick subgenus Ixodiopsis; (2) present the results of the authors' original research on the taxonomy and bionomics of this close-knit assemblage; and (3) analyse the evolutionary and zoogeographic history of this group in the light of current phylogenetic methodology. This Holarctic subgenus, often referred to as the "Ixodes angustus group", contains 7 species: I. angustus, I. eastoni, I. ochotonae, I. pomerantzevi, I. soricis, I. stromi and I. woodi. This book contains a diagnosis of Ixodiopsis, keys (to males, females, nymphs and larvae), synopses of species, material examined and sections on phylogenetics, ecology and zoogeography. There are 2 appendixes: a glossary, and a classified host-parasite list. A comprehensive index to the tick species completes the book.
KW  - biosystematics
KW  - ecology
KW  - ectoparasites
KW  - geographical distribution
KW  - Holarctic Region
KW  - hosts
KW  - keys
KW  - phylogeny
KW  - redescriptions
KW  - taxonomy
KW  - wild animals
KW  - zoogeography
KW  - Asia
KW  - Europe
KW  - North America
KW  - Acari
KW  - Arachnida
KW  - insectivores
KW  - Ixodes
KW  - Lagomorpha
KW  - mammals
KW  - rodents
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Ixodes
KW  - America
KW  - animal geography
KW  - Ixodes angustus
KW  - Ixodes eastoni
KW  - Ixodes ochotonae
KW  - Ixodes pomerantzevi
KW  - Ixodes soricis
KW  - Ixodes stromi
KW  - Ixodes woodi
KW  - Ixodiopsis
KW  - revision
KW  - systematics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Biological Resources (Animal) (PP710) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prosthetic joint infection with Actinomyces viscosus.
AU  - Cohen, O. J.
AU  - Keiser, J.
AU  - Pollner, J.
AU  - Parenti, D. M.
JO  - Infectious Diseases in Clinical Practice
JF  - Infectious Diseases in Clinical Practice
Y1  - 1993///
VL  - 2
IS  - 5
SP  - 349
EP  - 351
SN  - 1056-9103
AD  - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200710.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - A case is reported in a 61-yr-old man from the USA who presented with a 3-wk history of left hip pain with decreased range of motion and fever, 16 yr after a total left hip replacement. Radiographs of the left hip revealed diffuse destruction of the left hip joint with large amounts of heterotopic bone. There was marked deformity of the proximal femur with evidence of periosteal reaction along its lateral margin. The infected left hip prosthesis was removed and a pathological examination of the native bone showed chronic suppurative arthritis and osteomyelitis. A Gram stain of pus obtained from the left hip showed rare, pleomorphic, Gram positive organisms, identified as A. viscosus. Symptoms resolved after intravenous penicillin therapy with no recurrence in 6 months of follow-up. A search for the primary focus of A. viscosus infection was inconclusive. 13 previously reported cases of extraoral A. viscosus infection are also discussed.
KW  - actinomycosis
KW  - arthritis
KW  - case reports
KW  - human diseases
KW  - joints (animal)
KW  - predisposition
KW  - prostheses
KW  - North America
KW  - USA
KW  - Washington
KW  - Actinomyces viscosus
KW  - man
KW  - Actinomyces
KW  - Actinomycetaceae
KW  - Actinomycineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - bacterium
KW  - joints
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A comparison of risk factors for human immunodeficiency virus and hepatitis B virus infections in homosexual men.
AU  - Koziol, D. E.
AU  - Saah, A. J.
AU  - Odaka, N.
AU  - Muñoz, A.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1993///
VL  - 3
IS  - 4
SP  - 434
EP  - 441
SN  - 1047-2797
AD  - Koziol, D. E.: Hospital Epidemiology Service, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005089.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref.
N2  - The authors analysed cross-sectional data from 1062 homosexual men recruited in Baltimore, USA, during 1984, to directly compare risk factors for human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Using polychotomous logistic regression, risk factor odds ratios (ORs) and 95% confidence intervals were determined for men with HIV alone, men with HBV alone, and men with both HIV and HBV, compared to seronegative men, and paired comparisons among these subgroups. Factors associated with the serological prevalence of HIV alone and HBV alone (with respective ORs) included anal receptive intercourse (HIV OR = 1.23; HBV OR = 1.12), history of gonorrhea (HIV OR = 4.58; HBV OR = 2.52) and rectal douching (HIV OR = 1.41; HBV OR = 1.20). Additional factors associated with HBV alone were years of homosexual activity (OR = 1.65), sexual activity with a person who developed acquired immunodeficiency syndrome (AIDS) (OR = 1.98), and lifetime number of male sex partners (OR = 1.25). HIV and HBV coprevalence was associated with anal receptive intercourse (OR = 1.36), history of gonorrhea (OR = 2.94), rectal douching (OR = 1.45), sexual activity with a person who developed AIDS (OR = 3.87), lifetime number of male sex partners (OR = 1.21), and the lifetime sum of sexually transmitted diseases (OR = 1.47). These findings reinforce the need for following safer-sex guidelines to prevent both infections and in the case of HBV the prevention strategies should include vaccination.
KW  - homosexuality
KW  - human immunodeficiency viruses
KW  - mixed infections
KW  - risk factors
KW  - USA
KW  - hepatitis B virus
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - multiple infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Estrogen receptor status and dietary intakes in breast cancer patients.
AU  - Harlan, L. C.
AU  - Coates, R. J.
AU  - Block, G.
AU  - Greenberg, R. S.
AU  - Ershow, A.
AU  - Forman, M.
AU  - Austin, D. F.
AU  - Chen, V.
AU  - Heymsfield, S. B.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1993///
VL  - 4
IS  - 1
SP  - 25
EP  - 31
SN  - 1044-3983
AD  - Harlan, L. C.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19931465513.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - The association between oestrogen receptor status and the intake of nutrients and food groups was studied in 689 black and white women 20 to 79 years old with breast cancer newly diagnosed in 1985 and 1986. Medical records were reviewed and interview data collected, including a 34-item food frequency questionnaire. Positive oestrogen receptor status was positively associated with age and inversely associated with parity and oral contraceptive use. White women were more likely to have oestrogen receptor-positive tumours. A high percentage of energy from fat was associated with oestrogen receptor-positive cancer and a high percentage from fat with receptor-negative cancer. The findings indicate that women with breast cancer who are on diets with a high proportion of energy from fat are more likely to have oestrogen receptor-positive tumours.
KW  - carbohydrates
KW  - diet
KW  - diet studies
KW  - ethnic groups
KW  - fats
KW  - mammary gland neoplasms
KW  - oestrogens
KW  - receptors
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - estrogens
KW  - mammary tumour
KW  - saccharides
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465513&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Patterns of pesticide use among farmers: implications for epidemiologic research.
AU  - Blair, A.
AU  - Zahm, S. H.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1993///
VL  - 4
IS  - 1
SP  - 55
EP  - 62
SN  - 1044-3983
AD  - Blair, A.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932023554.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Epidemiological studies from various countries suggest that farmers are at an increased risk from cancer. It has been suggested that this increased risk may be linked to pesticide exposure, although the validity and reliabilty of information on pesticide usage obtained by recall has often been questioned. A survey was carried out to investigate the accuracy with which both farmers and their surrogates recalled both the frequency and identity of the pesticides used. Surrogates were a poorer source of information than the farmers themselves and underreported both the number of pesticides used and the frequency of their use. Comparison of information on pesticides used between farmers and their pesticide suppliers showed a moderate level of correlation. Many farmers tend to use a small number of popular pesticides with a frequency of twice a year or less. Only 7% of farmers reported the use of 5 or more pesticides in any one year and 20% more than 5 herbicides. Over a 10-year period the same 5 insecticides accounted for more than 70% of use by weight, whereas the top 5 herbicides accounted for 68% of use by weight in 1971 and 82% in 1976. R.D. Verschoyle
KW  - agriculture
KW  - farmers
KW  - health hazards
KW  - Occupations
KW  - pesticides
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - America (North)
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pesticide exposures and multiple myeloma in Iowa men.
AU  - Brown, L. M.
AU  - Burmeister, L. F.
AU  - Everett, G. D.
AU  - Blair, A.
JO  - Cancer Causes and Control
JF  - Cancer Causes and Control
Y1  - 1993///
VL  - 4
IS  - 2
SP  - 153
EP  - 156
AD  - Brown, L. M.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19940803652.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A population-based case-control study of 173 white men with multiple myeloma (MM) and 650 controls was conducted in Iowa (USA), an area with a large farming population, to evaluate the association between MM, agricultural risk factors, and exposure to individual pesticides. A slight statistically non-significant elevated risk for MM was seen among farmers. Although slight excesses were observed, there was no significant associations between MM and handling either classes of pesticides or specific pesticides. This study found little evidence to suggest an association between risk of MM and farming or pesticides.
KW  - farmers
KW  - myeloma
KW  - neoplasms
KW  - occupational hazards
KW  - pesticides
KW  - poisoning
KW  - Iowa
KW  - USA
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancers
KW  - toxicosis
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Occupational Health and Safety (VV900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803652&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary associations in a case-control study of endometrial cancer.
AU  - Potischman, N.
AU  - Swanson, C. A.
AU  - Brinton, L. A.
AU  - McAdams, M.
AU  - Barrett, R. J.
AU  - Berman, M. L.
AU  - Mortel, R.
AU  - Twiggs, L. B.
AU  - Wilbanks, G. D.
AU  - Hoover, R. N.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1993///
VL  - 4
IS  - 3
SP  - 239
EP  - 250
SN  - 0957-5243
AD  - Potischman, N.: Nutritional Epidemiology Section, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, Suite 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941401541.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Human Nutrition
N2  - Despite the established role of obesity in the aetiology of endometrial neoplasms, limited data are available from analytical epidemiological studies on the association of risk with dietary factors. A case-control study of 399 cases and 296 controls conducted in 5 areas of the USA from 1 June 1987 to 15 May 1990, enables evaluation of risk related to dietary intakes adjusted for potential confounders. Energy intake was associated modestly with increased risk (odds ratio (OR) 1.5; 95% confidence interval (CI) 0.9-2.5 for highest vs. lowest quartiles of intake), with the principal contributors being fat and protein energy. After adjustment for other risk factors, including body mass, increased risk was associated with higher intakes of fat. Several components of fat investigated were associated with increased risk, although associations were slightly stronger for saturated fat (OR 2.1, CI 1.2-3.7) and oleic acid (OR 2.2, CI 1.2-4.0) than for linoleic acid (OR 1.6, CI 0.9-2.8). Food-group analyses showed intake of complex carbohydrates, and specifically of breads and cereals, associated with reduced risks (OR 0.6, CI 0.4 to 1.1), whereas animal fat and fried foods were associated with increased risks (OR 1.5 and 1.7, respectively). The relations of endometrial neoplasms with animal fat and complex carbohydrates were independent. No consistent associations were noted for intakes of cholesterol, fibre, retinol and ascorbic acid, individual carotenoids or folate-rich foods. The data imply an aetiologic role for a diet rich in total fat and/or animal fat and low in complex carbohydrates with endometrial neoplasms. These associations are consistent with a hormonal mechanism and were independent of the associations of obesity and other risk factors.
KW  - carbohydrates
KW  - carcinoma
KW  - diet studies
KW  - endometrium
KW  - fats
KW  - protein intake
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - endometrial area
KW  - saccharides
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401541&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Race and sex differences in associations of vegetables, fruits, and carotenoids with lung cancer risk in New Jersey (United States).
AU  - Dorgan, J. F.
AU  - Ziegler, R. G.
AU  - Schoenberg, J. B.
AU  - Hartge, P.
AU  - McAdams, M. J.
AU  - Falk, R. T.
AU  - Wilcox, H. B.
AU  - Shaw, G. L.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1993///
VL  - 4
IS  - 3
SP  - 273
EP  - 281
SN  - 0957-5243
AD  - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941401542.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - Data from a case-control study made in New Jersey, USA, between 1980 and 1983 were used to evaluate race and sex differences in associations of vegetable, fruit and carotenoid consumption with lung carcinoma. Cases included 736 white men, 860 white women, 269 black men and 86 black women with incident, histologically confirmed, primary neoplasms of the trachea, bronchus or lung. Controls were 548 white men, 473 white women, 170 black men and 47 black women. Usual intakes of vegetables (predominantly yellow/green) and fruit (predominantly yellow/orange) as well as other food sources of carotenoids were ascertained by a food frequency questionnaire. White women showed significant inverse associations of lung neoplasms with vegetables, fruit and carotenoids. White men showed non-significant inverse associations with vegetables and carotenoids, and black women just with vegetables. No inverse associations were found for black men. Vegetable consumption was associated with risk of all histologic types of lung neoplasms, but the pattern of increasing risk with decreasing intake was limited to smokers. It is inferred that consumption of yellow/green vegetables and carotenoids may confer protection from lung neoplasms to white men and white women smokers. Further studies are needed to clarify the effect in blacks.
KW  - carcinoma
KW  - carotenoids
KW  - diet studies
KW  - ethnic groups
KW  - fruit
KW  - intake
KW  - lungs
KW  - risk
KW  - sex differences
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - tetraterpenoids
KW  - United States of America
KW  - vegetable crops
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401542&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - dbEST - database for "expressed sequence tags".
AU  - Boguski, M. S.
AU  - Lowe, T. M. J.
AU  - Tolstoshev, C. M.
JO  - Nature Genetics
JF  - Nature Genetics
Y1  - 1993///
VL  - 4
IS  - 4
SP  - 332
EP  - 333
SN  - 1061-4036
AD  - Boguski, M. S.: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, Room 8N-805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
N1  - Accession Number: 19950109837.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref.
N2  - This paper describes a new database that has been set up for partial, 'single-pass' cDNA sequences, also known as expressed sequence tags. Such sequences, and associated information, may be sent via E-mail or Internet to the National Center for Biotechnology Information. The database is available for public access.
KW  - databases
KW  - nucleotide sequences
KW  - rice
KW  - arabidopsis thaliana
KW  - caenorhabditis elegans
KW  - macropus eugenii
KW  - man
KW  - mice
KW  - Oryza
KW  - plasmodium falciparum
KW  - Rhabditida
KW  - Arabidopsis
KW  - Brassicaceae
KW  - Capparidales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Caenorhabditis
KW  - Rhabditidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - Macropus
KW  - Macropodidae
KW  - Diprotodontia
KW  - marsupials
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Muridae
KW  - rodents
KW  - Poaceae
KW  - Cyperales
KW  - monocotyledons
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Capparales
KW  - data banks
KW  - DNA sequences
KW  - nematodes
KW  - paddy
KW  - Secernentea
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950109837&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occasional binges by moderate drinkers: implications for birth outcomes.
AU  - Tolo, K. A.
AU  - Little, R. E.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1993///
VL  - 4
IS  - 5
SP  - 415
EP  - 420
SN  - 1044-3983
AD  - Tolo, K. A.: Epidemiology Branch, Mail Drop A3-05, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19941404329.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Human Nutrition
N2  - The effects of occasional alcohol binges on birth outcomes were studied in a cohort of live singletons born to 709 moderate drinkers recruited from a health maintenance organization in Seattle, USA before their sixth month of pregnancy. Infants of women with one or more binges in the month before pregnancy or in the first trimesters were compared with those whose mothers reported no binges in either period. Mean values of birth weight, length, head circumference, gestational age, intrauterine growth and Apgar scores did not differ notably between the 2 groups. The risk of having an adverse neonatal discharge diagnosis initially appeared lower in infants of binging mothers, but this difference vanished after recategorization of the variable and control for confounding. The results indicate that occasional binges, during a broad window of exposure and among otherwise moderate drinkers, did not adversely affect the birth outcomes examined.
KW  - alcoholic beverages
KW  - birth weight
KW  - body measurements
KW  - fetal development
KW  - intake
KW  - mothers
KW  - neonates
KW  - pregnancy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gestation
KW  - newborn infants
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404329&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States).
AU  - Zheng, W.
AU  - McLaughlin, J. K.
AU  - Gridley, G.
AU  - Bjelke, E.
AU  - Schuman, L. M.
AU  - Silverman, D. T.
AU  - Wacholder, S.
AU  - Co-Chien, H. T.
AU  - Blot, W. J.
AU  - Fraumeni, J. F., Jr.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1993///
VL  - 4
IS  - 5
SP  - 477
EP  - 482
SN  - 0957-5243
AD  - Zheng, W.: Biostatistics Branch, National Cancer Institute, 6130 Executive Blvd., Room 415 Bethesda, MD 20892, USA.
N1  - Accession Number: 19941406677.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Human Nutrition
N2  - Risk factors for pancreatic neoplasms were evaluated in a cohort study of 17 633 white men in the USA who responded to a mailed questionnaire in 1966 and were followed-up to 1986 for mortality. Cigarette smoking and alcohol consumption were important risk factors for pancreatic neoplasms. Risks increased significantly with number of cigarettes smoked, reaching 4-fold for smokers of 25 or more cigarettes per day relative to non-smokers. Alcohol intake also was related significantly to risk, with consumers of 10 or more drinks per month having 3 times the risk of non-drinkers, but dose-response trends among drinkers were not smooth. Coffee consumption was unrelated to risk. Dietary analyses revealed a rising rate of pancreatic neoplasms mortality with increasing consumption of meat after adjustment for other risk factors. Men in the highest quartile of meat intake had about 3 times the risk of those in the lowest quartile. No consistent association, however, was observed for consumption of fruits, vegetables or grains.
KW  - alcoholic beverages
KW  - diet
KW  - men
KW  - neoplasms
KW  - pancreas
KW  - tobacco smoking
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406677&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Moderate alcohol consumption and the risk of endometrial cancer.
AU  - Swanson, C. A.
AU  - Wilbanks, G. D.
AU  - Twiggs, L. B.
AU  - Mortel, R.
AU  - Berman, M. L.
AU  - Barrett, R. J.
AU  - Brinton, L. A.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1993///
VL  - 4
IS  - 6
SP  - 530
EP  - 536
SN  - 1044-3983
AD  - Swanson, C. A.: Environmental Epidemiology Branch, National Cancer Institute, Bethedsa, MD, USA.
N1  - Accession Number: 19941407499.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Human Nutrition
N2  - In a multicentre case-control study that included 400 cases and 297 controls, the relation of moderate alcohol consumption to risk of endometrial carcinogenesis was studied. Average weekly intake of alcohol was estimated during adulthood from the reported frequency of intake of beer, wine and spirits. The relative risk of endometrial neoplasms was 0.82 (95% confidence interval = 0.6 to 1.2) among women who drank, compared with lifelong abstainers. The weak protective effect of alcohol was due to a stronger inverse association among young women (&lt;55 years). In young women, the age-adjusted relative risks for 3 levels of drinking (&lt;1, 1 to 4 and &gt;4 drinks per week), from lowest to highest, were 0.78, 0.64 and 0.41 compared with non-drinkers. The risk estimates were not materially altered after adjustment for a variety of factors related to alcohol intake and to low risk of the disease (for example, smoking, oral contraceptive use, low body mass index, increased physical activity). The protective effect of alcohol could not be attributed to 1 particular type of alcohol-containing beverage, but beer appeared to have the most pronounced effect. These results suggest an inverse association between moderate alcohol consumption and endometrial neoplasm risk among young women, but support for a causal association is qualified and requires confirmation.
KW  - alcoholic beverages
KW  - carcinoma
KW  - endometrium
KW  - intake
KW  - neoplasms
KW  - risk
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - endometrial area
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407499&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The 6th Annual Meeting of NCVDG for AIDS.
AU  - Limpakanjanarat, K.
AU  - Makonkawkeyoon, S.
JO  - Thai AIDS Journal
JF  - Thai AIDS Journal
Y1  - 1993///
VL  - 5
IS  - 3
SP  - 113
EP  - 120
SN  - 0857-8575
AD  - Limpakanjanarat, K.: Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), Thailand.
N1  - Accession Number: 19942050904.  Publication Type: Journal Article.  Corporate Author: Thailand, Cooperative Vaccine Development Groups (NCVDG) for AIDS Language: Thai. 
N2  - A review for Thai readers.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - prevention
KW  - research
KW  - vaccines
KW  - Thailand
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050904&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effector functions of activated macrophages against parasites.
AU  - James, S. L.
AU  - Nacy, C.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1993///
VL  - 5
IS  - 4
SP  - 518
EP  - 523
SN  - 0952-7915
AD  - James, S. L.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802191.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Subject Subsets: Helminthology; Protozoology; Tropical Diseases; Public Health
N2  - The role of activated macrophages as a major effector cell of anti-parasitic immunity is reviewed with regard to: induction of macrophage cytotoxic activity; effector reactions; downregulation of activated macrophage effector reactions. The contribution of research on cytokine function to the understanding of the immune mechanisms regulating murine macrophage function, and the effector molecules employed by these cells to kill both intracellular and extracellular parasites, is discussed.
KW  - cytokines
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - macrophages
KW  - parasites
KW  - reviews
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802191&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transmission-blocking immunity against malaria and other vector-borne diseases.
AU  - Kaslow, D. C.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1993///
VL  - 5
IS  - 4
SP  - 557
EP  - 565
SN  - 0952-7915
AD  - Kaslow, D. C.: Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B1-37, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802196.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2  - This review covers: the biological basis of malaria transmission-blocking vaccines (immunogenicity of gametocyte target antigens, antigenic diversity of gametocyte target antigens, boosting with subsequent natural infection); gametocyte/gamete (pre-fertilization) target antigens (Pf11.1/Pfs2400, Pfs230, Pfs48/45, Pfs40, Pfg27/25, Pfs16); zygote/early ookinete (post-fertilization) target antigens (Pfs25, Pfs28/Pgs28/Pbs21); late midgut stage (late ookinete/oocyst) target antigens (chitinase, mosquito-produced protease); targets for other vector-borne diseases (anti-mosquito antigen vaccines, anti-tick midgut vaccines).
KW  - human diseases
KW  - malaria
KW  - parasites
KW  - reviews
KW  - transmission blocking immunity
KW  - vector-borne diseases
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802196&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of fibroblast hyaluronic acid production by suramin.
AU  - August, E. M.
AU  - Duncan, K. L. K.
AU  - Malinowski, N. M.
AU  - Cysyk, R. L.
JO  - Oncology Research
JF  - Oncology Research
Y1  - 1993///
VL  - 5
IS  - 10/11
SP  - 415
EP  - 422
SN  - 0965-0407
AD  - August, E. M.: Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5E10, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940805373.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9004-61-9, 145-63-1.  Subject Subsets: Helminthology
KW  - anthelmintics
KW  - helminths
KW  - hyaluronic acid
KW  - inhibition
KW  - parasites
KW  - suramin
KW  - parasitic worms
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805373&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The National Health and Nutrition Examination Survey III: describing the health and nutritional status of older Americans.
AU  - Harris, T.
AU  - Burt, V. L.
AU  - Briefel, R. R.
AU  - McDowell, M.
AU  - Sorenson, A. W.
JO  - Aging, Clinical and Experimental Research
JF  - Aging, Clinical and Experimental Research
Y1  - 1993///
VL  - 5
IS  - 2, SUPP 1
SP  - 29
EP  - 36
SN  - 0394-9532
AD  - Harris, T.: National Institute on Aging, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402150.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 11 ref. Subject Subsets: Human Nutrition
N2  - A brief overview of the nutritional content of the National Health and Nutrition Survey III (NHANES III) in the USA is provided.
KW  - diet studies
KW  - nutrition surveys
KW  - old age
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Nutrition and aging - current issues and future imperatives
KW  - nutritional surveys
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402150&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recommendations for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1993///
VL  - 6
IS  - 1
SP  - 46
EP  - 55
SN  - 0894-9255
AD  - H. Masur, National Institutes of Health, Building 10, Room 7043, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930883161.  Publication Type: Journal Article.  Corporate Author: US Public Health Service Task Force on Antipneumocystis Prophylaxis in Patients with Human Immunodeficiency Virus Language: English.  Number of References: 36 ref. Subject Subsets: Protozoology; Medical & Veterinary Mycology
N2  - The Task Force set up in 1989 by the US Public Health Service to consider the expanding knowledge base about prevention of Pneumocystis carinii pneumonia (PCP) in adults with human immunodeficiency virus (HIV) infection was reconvened in October 1991 to consider information that has become available since the first report about the efficacy and safety of aerosolized pentamidine, oral trimethoprim sulfamethoxazole (TMP-SMX), and the importance of prospective monitoring of CD4+ cell counts. The revised recommendations are set out under the following headings : Is prophylaxis for PCP desirable?; How should patients be monitored to determine if they are at increased risk of PCP?; Who should receive prophylaxis for PCP (primary prophylaxis, secondary prophylaxis)?; What prophylactic regimens are proven to be safe and effective and how should they be administered (TMP-SMX, aerosol pentamidine, other drugs)?; Which form of prophylaxis is best?; Management of prophylaxis-related toxicity; Need for close monitoring of patients receiving prophylaxis; If a patient develops an episode of PCP while receiving prophylaxis, what regimen should be used for treating the acute episode and what prophylactic regimen should be resumed after successful completion of acute therapy? What is recommended for children? Do any prophylactic regimens against PCP also provide protection against other opportunistic infections? Cost of PCP prophylaxis.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - guidelines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - opportunistic infections
KW  - parasites
KW  - predisposition
KW  - prophylaxis
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - recommendations
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883161&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bladder cancer and bilharziasis today.
AU  - Khaled, H. M.
JO  - Cancer Journal
JF  - Cancer Journal
Y1  - 1993///
VL  - 6
IS  - 2
SP  - 65
EP  - 71
SN  - 0765-7846
AD  - Khaled, H. M.: Medical Oncology Department, National Cancer Institute, Fom El-Khalig Square, Cairo, Egypt.
N1  - Accession Number: 19950803554.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Helminthology
N2  - This review article examines the current position of bladder cancer and its association with schistosomiasis. The geographical distribution and life cycle of Schistosoma are discussed followed by a consideration of the aetiological relationship between bladder cancer and Schistosoma, the effect of schistosomiasis on the host immune system, and the pathology and natural history of bladder cancer. The second half of the article is concerned with the treatment of bladder cancer, essentially radical cystectomy and radiotherapy, and its early detection and prevention.
KW  - bladder diseases
KW  - carcinoma
KW  - helminths
KW  - human diseases
KW  - parasites
KW  - reviews
KW  - schistosomiasis
KW  - Digenea
KW  - man
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - general account
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 infection of the brain.
AU  - Atwood, W. J.
AU  - Berger, J. R.
AU  - Kaderman, R.
AU  - Tornatore, C. S.
AU  - Major, E. O.
JO  - Clinical Microbiology Reviews
JF  - Clinical Microbiology Reviews
Y1  - 1993///
VL  - 6
IS  - 4
SP  - 339
EP  - 366
SN  - 0893-8512
AD  - Atwood, W. J.: Section on Molecular Virology and Genetics, Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19942026323.  Publication Type: Journal Article.  Language: English.  Number of References: 389 ref. Subject Subsets: Public Health
N2  - This extensive review covers the life cycle of HIV, clinical manifestations of CNS infection with HIV-1, neurotropism, pathogenesis, diagnosis and treatment. D.W. FitzSimons
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - brain
KW  - Central nervous system
KW  - Clinical aspects
KW  - Diagnosis
KW  - HIV infections
KW  - infections
KW  - nervous system
KW  - Neurology
KW  - Paediatrics
KW  - Pathogenesis
KW  - pathology
KW  - reviews
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - cerebrum
KW  - clinical picture
KW  - CNS
KW  - human immunodeficiency virus infections
KW  - Human immunodeficiency virus type 1
KW  - neuropathology
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026323&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Measurement of cerebrospinal fluid antibody to the HIV-1 principal neutralizing determinant (V3 loop).
AU  - Lucey, D. R.
AU  - VanCott, T. C.
AU  - et al.
AU  - Loomis, L. D. (
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1993///
VL  - 6
IS  - 9
SP  - 994
EP  - 1001
SN  - 0894-9255
AD  - Lucey, D. R.: Experimental Immunology Branch/NCI, Building 10, Room 4B-17, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004703.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
KW  - Antibodies
KW  - Cerebrospinal fluid
KW  - glycoproteins
KW  - HIV infections
KW  - Immune response
KW  - Immunology
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Intrathecal antibody production
KW  - V3 loop
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004703&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of intravenous immunoglobulin (IVIG) on CD4+ lymphocyte decline in HIV-infected children in a clinical trial of IVIG infection prophylaxis.
AU  - Mofenson, L. M.
AU  - Bethel, J.
AU  - Moye, J. Jr
AU  - Flyer, P.
AU  - Nugent, R.
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1993///
VL  - 6
IS  - 10
SP  - 1103
EP  - 1113
SN  - 0894-9255
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Building 6100, Room 4B11, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004742.  Publication Type: Journal Article.  Corporate Author: USA, National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group Language: English.  Registry Number: 308067-57-4. 
KW  - HIV infections
KW  - Immunoglobulins
KW  - Paediatrics
KW  - Passive immunization
KW  - Treatment
KW  - gamma-globulins
KW  - human immunodeficiency virus infections
KW  - immune globulins
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004742&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fusogenicity of mutant and chimeric proviruses derived from molecular clones of cytopathic and noncytopathic human immunodeficiency virus type 2.
AU  - Arya, S. K.
AU  - Sadaie, M. R.
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1993///
VL  - 6
IS  - 11
SP  - 1205
EP  - 1211
SN  - 0894-9255
AD  - Arya, S. K.: Laboratory of Tumor Cell Biology, Bldg 37, Rm 6A09, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942004912.  Publication Type: Journal Article.  Language: English. 
KW  - Conformation
KW  - Cytopathogenicity
KW  - Envelope glycoproteins
KW  - Pathogenesis
KW  - Human immunodeficiency virus 2
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - body conformation
KW  - HUMAN IMMUNODEFICIENCY VIRUS TYPE 2
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942004912&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetic modeling of selenium in humans using stable isotope tracers.
AU  - Patterson, B. H.
AU  - Zech, L. A.
AU  - Swanson, C. A.
AU  - Levander, O. A.
JO  - Journal of Trace Elements and Electrolytes in Health and Disease
JF  - Journal of Trace Elements and Electrolytes in Health and Disease
Y1  - 1993///
VL  - 7
IS  - 2
SP  - 117
EP  - 120
SN  - 0931-2838
AD  - Patterson, B. H.: Biometry Branck, DCPC, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941409219.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
N2  - The pharmacokinetics of selenium was investigated in 38 subjects who each received a single 200 µg dose of selenium as sodium selenite or as L-selenomethionine (SeMet). Plasma, urine and faeces were collected for 2 weeks. 2 kinetic models, 1 for each form, were developed. The Selenite Model included absorption distributed along the GI tracts, transport through 4 plasma components, a subsystem consisting of the liver and pancreas and a slowly turning-over tissue pool. This model was used as a starting model for SeMet and modified. The amount of label absorbed was increased as was hepato-pancreatic uptake, a pathway from the plasma back to the liver was added that provided for recycling of label, and an additional tissue pool was incorporated into the model. Turnover times were shorter for SeMet than for selenite for the plasma, liver and pancreas, and the tissues, but far longer for the whole body; this reflects the recycling of SeMet, but not of selenite. Such reutilization could be advantageous as it allows the body to redistribute Se.
KW  - adults
KW  - pharmacokinetics
KW  - selenium
KW  - trace elements
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - microelements
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409219&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of dnaJ, dnaK, and grpE homologues from Borrelia burgdorferi and complementation of Escherichia coli mutants.
AU  - Tilly, K.
AU  - Hauser, R.
AU  - Campbell, J.
AU  - Ostheimer, G. J.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993///
VL  - 7
IS  - 3
SP  - 359
EP  - 369
SN  - 0950-382X
AD  - Tilly, K.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940500136.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - The heat-shock proteins DnaJ, DnaK and GrpE are involved in the replication of various species of DNA in E. coli, in addition to their roles in other processes, including protein disaggregation and export. The B. burgdorferi homologues of these genes were cloned. DNA sequence analysis revealed an open reading frame encoding a protein that is 62% identical to the E. coli DnaK protein. Genes homologous to the E. coli grpE and dnaJ genes, encoding products 28 and 39% identical to their homologues, are located up- and downstream, respectively, of the B. burgdorferi dnaK gene. No obvious promoters were detected in the sequenced DNA, although a potential transcription terminator was found downstream of the dnaJ gene, so these 3 genes may form an operon, perhaps with a fourth gene located upstream of the grpE gene. The grpE homologue complemented an E. coli grpE mutant and the dnaJ homologue complemented an E. coli dnaJ mutant, whereas the B. burgdorferi dnaK gene did not complement dnaK mutants.
KW  - clones
KW  - DNA
KW  - genes
KW  - heat shock proteins
KW  - molecular genetics
KW  - nucleotide sequences
KW  - operons
KW  - Borrelia burgdorferi
KW  - Escherichia coli
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - E. coli
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500136&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Filarial infections.
AU  - Ottesen, E. A.
JO  - Infectious Disease Clinics of North America
JF  - Infectious Disease Clinics of North America
Y1  - 1993///
VL  - 7
IS  - 3
SP  - 619
EP  - 633
SN  - 0891-5520
AD  - Ottesen, E. A.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940802397.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Helminthology
N2  - This review of human filarial infections covers: recent clinical advances (clinical presentations, diagnosis, treatment, chemoprophylaxis); specific clinical problems (evaluation of the patient with asymptomatic eosinophilia for suspected filarial infection, treatment of the asymptomatic patient, treatment of patients with lymphatic filariasis (Wuchereria bancrofti or Brugia malayi), treatment of patients with loiasis, treatment of patients with onchocerciasis, advice to travellers about antifilarial prophylaxis, management of "nonpathogenic" filarial infections).
KW  - filariids
KW  - helminths
KW  - human diseases
KW  - parasites
KW  - reviews
KW  - Brugia malayi
KW  - Loa loa
KW  - man
KW  - Mansonella
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Loa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - Wuchereria
KW  - African eyeworm
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802397&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Management of immunocompromised patients with evidence of an invasive mycosis.
AU  - Walsh, T. J.
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
Y1  - 1993///
VL  - 7
IS  - 5
SP  - 1003
EP  - 1026
SN  - 0889-8588
AD  - Walsh, T. J.: Pediatric Branch, Infectious Disease Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200812.  Publication Type: Journal Article.  Language: English.  Number of References: 112 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The management of immunocompromised patients with evidence of invasive mycosis is reviewed. The treatment of infections caused by Candida spp. (mucosal candidosis, candidaemia, disseminated candidosis, pulmonary candidosis), Aspergillus spp. (invasive pulmonary aspergillosis, extrapulmonary aspergillosis), emerging opportunistic mycoses due to Fusarium spp., Trichosporon beigelii, agents of zygomycosis, Pseudallescheria boydii, Scedosporium spp., agents of phaeohyphomycosis, Malassezia furfur and Cryptococcus neoformans, and endemic mycoses due to Coccidioides immitis and Histoplasma capsulatum is discussed. Empiric antifungal therapy and the use of recombinant human cytokines in the management of granulocytopenic patients are considered.
KW  - antifungal agents
KW  - aspergillosis
KW  - candidosis
KW  - coccidioidomycosis
KW  - cryptococcosis
KW  - cytokines
KW  - drug therapy
KW  - fusariosis
KW  - histoplasmosis
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunosuppression
KW  - immunotherapy
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - phaeohyphomycosis
KW  - predisposition
KW  - reviews
KW  - therapy
KW  - zygomycosis
KW  - Aspergillus
KW  - Candida
KW  - Coccidioides immitis
KW  - Cryptococcus neoformans
KW  - Fusarium
KW  - Histoplasma capsulatum
KW  - Malassezia furfur
KW  - man
KW  - Pseudallescheria boydii
KW  - Scedosporium
KW  - Trichosporon beigelii
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Coccidioides
KW  - Onygenaceae
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Histoplasma
KW  - Malassezia
KW  - Malasseziales
KW  - Ustilaginomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Ajellomyces capsulatus
KW  - candidiasis
KW  - chemotherapy
KW  - chromomycosis
KW  - coccidiomycosis
KW  - european blastomycosis
KW  - fungistats
KW  - fungus
KW  - fusarioses
KW  - Hyphomycetes
KW  - phycomycosis
KW  - therapeutics
KW  - trichosporonosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cellular immune factors associated with mother-to-infant transmission of HIV.
AU  - Clerici, M.
AU  - Sison, A. V.
AU  - et al.
AU  - Berzofsky, J. A. (
AU  - Shearer, G. M.
JO  - AIDS
JF  - AIDS
Y1  - 1993///
VL  - 7
IS  - 11
SP  - 1427
EP  - 1433
SN  - 0269-9370
AD  - Clerici, M.: (G.M. Shearer) Experimental Immunology Branch, National Cancer Institute, Building 10, Room 4B-17, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004980.  Publication Type: Journal Article.  Language: English. 
KW  - Cell mediated immunity
KW  - HIV infections
KW  - Maternal transmission
KW  - T lymphocytes
KW  - cellular immunity
KW  - human immunodeficiency virus infections
KW  - mother to child transmission
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004980&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Taxonomic status of Blastocystis hominis: reply.
AU  - Zierdt, C. H.
T2  - Parasitology Today
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1993///
VL  - 9
IS  - 1
SP  - 18
EP  - 18
AD  - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, Building 10, Room 2C-343, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930803168.  Publication Type: Correspondence.  Language: English.  Number of References: 4 ref. Subject Subsets: Protozoology
N2  - In reply to the paper by Jiang and He (Parasitology Today (1993) 9 (1), 2-3), Zierdt outlines previous classifications of Blastocystis hominis and discusses the establishment of a separate classification for the parasite. The author agrees with the classification of a new subphylum (Blastocysta) proposed by Jiang and He but argues that it is difficult to state that 3 forms evolved from the evolutionarily earlier vacuolated form, since all can interchange in a single culture. It is suggested that caution must be exercised in assigning new cell form status as it may reflect structural response to nutritional changes.
KW  - life history
KW  - new subphylum
KW  - parasites
KW  - Taxonomy
KW  - Blastocystis hominis
KW  - protozoa
KW  - Blastocystis
KW  - Amoebida incertae sedis
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Blastocysta
KW  - systematics
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chitinase: a novel target for blocking parasite transmission?
AU  - Shahabuddin, M.
AU  - Kaslow, D. C.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1993///
VL  - 9
IS  - 7
SP  - 252
EP  - 255
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808105.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 9001-06-3.  Subject Subsets: Helminthology; Protozoology; Medical & Veterinary Entomology
N2  - The possible role of chitinase in the transmission (through their insect hosts) of Plasmodium, Leishmania, Brugia, Onchocerca and Trypanosoma is discussed. The parasites for which chitinase has been reported are listed in a table. It is suggested that the enzymes involved in chitin metabolism could be suitable candidates for vaccine development.
KW  - Biochemistry
KW  - chitinase
KW  - Enzymes
KW  - helminths
KW  - parasites
KW  - vaccines
KW  - Apicomplexa
KW  - Brugia
KW  - Leishmania
KW  - Nematoda
KW  - Onchocerca
KW  - Onchocercidae
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808105&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutational analysis of the assembly domain of the HIV-1 envelope glycoprotein.
AU  - Earl, P. L.
AU  - Moss, B.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1993///
VL  - 9
IS  - 7
SP  - 589
EP  - 594
SN  - 0889-2229
AD  - Earl, P. L.: Laboratory of Viral Diseases, Building 4, Room 237, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004608.  Publication Type: Journal Article.  Language: English. 
KW  - envelope protein gp41
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - Mutational analysis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Env
KW  - gp41
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Oligomerization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004608&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - How the discovery of Borrelia burgdorferi came about.
AU  - Burgdorfer, W.
A2  - Åsbrink, E.
A2  - Hovmark, A.
JO  - Clinics in Dermatology
JF  - Clinics in Dermatology
Y1  - 1993///
VL  - 11
IS  - 3
SP  - 335
EP  - 338
SN  - 0738-081X
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940501409.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - history
KW  - Lyme disease
KW  - reviews
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Ixodes ricinus
KW  - Ixodes scapularis
KW  - man
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - bacterium
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940501409&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunogenicity of a synthetic oligopeptide corresponding to antigenically common T-helper and B-cell neutralizing epitopes of the major outer membrane protein of Chlamydia trachomatis.
AU  - Su, H.
AU  - Caldwell, H. D.
JO  - Vaccine
JF  - Vaccine
Y1  - 1993///
VL  - 11
IS  - 11
SP  - 1159
EP  - 1166
SN  - 0264-410X
AD  - Su, H.: (H.D. Caldwell) National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19942025343.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A study using mice and cynomolgus monkeys.
KW  - antigens
KW  - Chlamydia trachomatis
KW  - Chlamydia
KW  - Chlamydiaceae
KW  - Chlamydiales
KW  - Chlamydiae
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - experimental vaccines
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025343&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccinees and vaccinia virus recombinants that express the surface glycoproteins of RSV.
AU  - Crowe, J. E. Jr
AU  - Collins, P. L.
AU  - London, W. T.
AU  - Chanock, R. M.
AU  - Murphy, B. R.
JO  - Vaccine
JF  - Vaccine
Y1  - 1993///
VL  - 11
IS  - 14
SP  - 1395
EP  - 1404
SN  - 0264-410X
AD  - Crowe, J. E. Jr: Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942025395.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - comparisons
KW  - efficacy
KW  - infections
KW  - live vaccines
KW  - recombinant vaccines
KW  - human respiratory syncytial virus
KW  - Pneumovirus
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Pneumovirinae
KW  - viruses
KW  - attenuated vaccines
KW  - immunogenicity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pulmonary cryptococcosis presenting as metastases in children with sarcomas.
AU  - Allende, M.
AU  - Pizzo, P. A.
AU  - Horowitz, M.
AU  - Pass, H. I.
AU  - Walsh, T. J.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1993///
VL  - 12
IS  - 3
SP  - 240
EP  - 243
SN  - 0891-3668
AD  - Allende, M.: T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931251740.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - Four cases are reported in 11, 15 and 16-yr-old boys and an 8-yr-old girl, all with sarcomas in remission, who developed asymptomatic pulmonary nodules presumed to be new pulmonary metastases from the solid primary tumour. All patients underwent a thoracotomy with excisional biopsy and the fully resected lesions were proved to be caused by Cryptococcus neoformans by culture with histopathological confirmation. Two patients received systemic antifungal therapy with fluconazole (400 mg/d) or ketoconazole (400 mg/d) and 2 patients were treated with surgical resection only. No patient subsequently developed a relapse of solid tumour or cryptococcosis.
KW  - children
KW  - Cryptococcosis
KW  - hosts
KW  - infections
KW  - lungs
KW  - neoplasms
KW  - predisposition
KW  - sarcoma
KW  - North America
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - european blastomycosis
KW  - fungus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251740&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Women's health and nutrition research: US governmental concerns.
AU  - Cummings, N. B.
JO  - Journal of the American College of Nutrition
JF  - Journal of the American College of Nutrition
Y1  - 1993///
VL  - 12
IS  - 4
SP  - 329
EP  - 336
SN  - 0731-5724
AD  - Cummings, N. B.: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940404577.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Human Nutrition
KW  - health
KW  - nutrition
KW  - nutrition research
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940404577&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Healthy adiposity in women: the Framingham Offspring Study.
AU  - Garrison, R. J.
JO  - Journal of the American College of Nutrition
JF  - Journal of the American College of Nutrition
Y1  - 1993///
VL  - 12
IS  - 4
SP  - 357
EP  - 362
SN  - 0731-5724
AD  - Garrison, R. J.: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940404574.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
N2  - A threshold for "healthy adiposity" was estimated by examining the relation between subscapular skinfolds thickness, a direct measure of adiposity, and cardiovascular disease risk factors in 1254 nonsmoking women who participated in the Framingham Offspring Study (USA). Cardiovascular disease risk factors, including blood pressure, fasting plasma lipoprotein cholesterol, plasma glucose and echocardiographically measured left ventricular mass were included. The optimal subscapular skinfold for women 20 to 39 years old was &lt;15 mm. Women 20 to 59 years old whose subscapular skinfolds were below this level had a mean body mass index (BMI) of 21.1 kg/m². Weight-for-height estimates for these women corresponded closely to the 1959 Metropolitan Life Insurance Company Desirable Weight table. The probability of having unhealthy adiposity was estimated for all women 20 to 59 years old for each (rounded) integer value grouping BMI. The probability of being above the healthy adiposity threshold increased rapidly across BMI levels &gt;20 and plateaued &gt;24. Thus, only women with BMI &lt;24 need assessment for adiposity status.
KW  - body composition
KW  - body fat
KW  - body measurements
KW  - cardiovascular diseases
KW  - nutrition surveys
KW  - risk
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - nutritional surveys
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940404574&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Primum non nocere: a pharmacologically inert pertussis toxoid alone should be the next pertussis vaccine.
AU  - Robbins, J. B.
AU  - Pittman, M.
AU  - Trollfors, B.
AU  - Lagergard, T. A.
AU  - Taranger, J.
AU  - Schneerson, R.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1993///
VL  - 12
IS  - 10
SP  - 795
EP  - 807
SN  - 0891-3668
AD  - Robbins, J. B.: National Institute of Child Health and Human Development, Laboratory and Developmental and Molecular Immunity, Building 6, Room 145, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028106.  Publication Type: Journal Article.  Language: English.  Number of References: 240 ref. Subject Subsets: Public Health
N2  - A review.
KW  - immunization
KW  - Pertussis
KW  - reviews
KW  - immune sensitization
KW  - whooping cough
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An analysis of AIDS incidence data by clustering trends.
AU  - Kafadar, K.
AU  - Karon, J. M.
JO  - Statistics in Medicine
JF  - Statistics in Medicine
Y1  - 1993///
VL  - 12
IS  - 3/4
SP  - 311
EP  - 326
SN  - 0277-6715
AD  - Kafadar, K.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 344, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020838.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The purpose of this paper is to group metropolitan areas in the USA according to the shape of the AIDS epidemic curve reported from each area. Only areas with a population of 1 million and reporting at least 400 AIDS cases are considered. By using cluster analysis the authors derived a dendrogram which suggests five different patterns of AIDS incidence (the distance measure between two areas was the variance of trimester-specific ratios of the smoothed number of reported AIDS cases). The authors suggest that modelling procedures may be more accurate if based on the groups so defined rather than one based on the overall data.D. Dunn
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - cluster analysis
KW  - Epidemiology
KW  - HIV infections
KW  - homosexuality
KW  - Incidence
KW  - mathematical models
KW  - men
KW  - Statistics
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - America (North)
KW  - Epidemic trends
KW  - homosexuals
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020838&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Case report of anorexia nervosa associated with Wilson's disease.
AU  - Gwirtsman, H. E.
AU  - Prager, J.
AU  - Henkin, R.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993///
VL  - 13
IS  - 2
SP  - 241
EP  - 244
SN  - 0276-3478
AD  - Gwirtsman, H. E.: Mood, Anxiety and Personality Disorders Research Branch, Division of Clinical Research, National Institute of Mental Health, Room 10C-24, 5600 Fisher Lane, Rockville, MD 20857, USA.
N1  - Accession Number: 19941402854.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 7440-50-8.  Subject Subsets: Human Nutrition
KW  - anorexia nervosa
KW  - case reports
KW  - copper
KW  - mineral metabolism disorders
KW  - nervous system diseases
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - neuropathy
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402854&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An attempt to modify unhealthful eating attitudes and weight regulation practices of young adolescent girls.
AU  - Killen, J. D.
AU  - Taylor, C. B.
AU  - Hammer, L. D.
AU  - Litt, I.
AU  - Wilson, D. M.
AU  - Rich, T.
AU  - Hayward, C.
AU  - Simmonds, B.
AU  - Kraemer, H.
AU  - Varady, A.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993///
VL  - 13
IS  - 4
SP  - 369
EP  - 384
SN  - 0276-3478
AD  - Killen, J. D.: National Institute of Child Health and Human Development, 6100 Executive Blvd., Bethesda, MD 20852, USA.
N1  - Accession Number: 19941404233.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - A study evaluating the effectiveness of a prevention curriculum designed to modify eating attitudes and unhealthy weight regulation practices of 967 girls (11 to 13 years old) is described. Prevention intervention was developed around the following principal components: instruction on the harmful effects of unhealthy weight regulation; promotion of healthy weight regulation through the practice of sound nutrition and dietary principles and regular aerobic physical activity; and development of coping skills for resisting the diverse sociocultural influences that appear linked to current popular obsessions with thinness and dieting. A significant increase in knowledge among girls receiving the intervention was observed and among high-risk students only, there was a small significant effect on body mass index. The findings question the wisdom of providing a curriculum directed at all young adolescents, most of whom are not at risk to develop an eating disorder. It is suggested that rather than targeting the entire population, a healthy weight curriculum designed to modify eating attitudes and unhealthy weight regulation practices of young adolescent girls might better focus on "at risk" students.
KW  - adolescents
KW  - appetite disorders
KW  - behaviour
KW  - body weight
KW  - children
KW  - diet
KW  - feeding behaviour
KW  - girls
KW  - nutrition education
KW  - prevention
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - behavior
KW  - eating disorders
KW  - feeding behavior
KW  - teenagers
KW  - Animal Behaviour (LL300) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404233&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Opportunistic/nosocomial infections. Treatment and developmental therapeutics. I. Cryptococcosis.
AU  - St. Georgiev, V.
JO  - Medicinal Research Reviews
JF  - Medicinal Research Reviews
Y1  - 1993///
VL  - 13
IS  - 4
SP  - 493
EP  - 506
SN  - 0198-6325
AD  - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200761.  Publication Type: Journal Article.  Language: English.  Number of References: 148 ref. Registry Number: 1397-89-3, 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - The treatment of Cryptococcus neoformans infections is reviewed, including clinical signs of cryptococcosis, use of amphotericin B, combinations of amphotericin B with 5-fluorocytosine [flucytosine] and other drugs, and amphotericin B esters.
KW  - amphotericin B
KW  - antifungal agents
KW  - cryptococcosis
KW  - drug combinations
KW  - drug therapy
KW  - flucytosine
KW  - human diseases
KW  - infections
KW  - reviews
KW  - therapy
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - 5-fluorocytosine
KW  - chemotherapy
KW  - european blastomycosis
KW  - fungistats
KW  - fungus
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen.
AU  - Gatignol, A.
AU  - Buckler, C.
AU  - Jeang, K. T.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1993///
VL  - 13
IS  - 4
SP  - 2193
EP  - 2202
SN  - 0270-7306
AD  - Gatignol, A.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942025037.  Publication Type: Journal Article.  Language: English.  Number of References: 74 ref. Registry Number: 63231-63-0. 
KW  - Genes
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - Nucleotide sequences
KW  - RNA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Binding protein
KW  - DNA sequences
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - ribonucleic acid
KW  - TAR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025037&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Opportunistic/nosocomial infections. Treatment and developmental therapeutics. Toxoplasmosis.
AU  - Georgiev, V. St.
JO  - Medicinal Research Reviews
JF  - Medicinal Research Reviews
Y1  - 1993///
VL  - 13
IS  - 5
SP  - 529
EP  - 568
SN  - 0198-6325
AD  - Georgiev, V. St.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Bldg., Room 4C-39, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804403.  Publication Type: Journal Article.  Language: English.  Number of References: 335 ref. Subject Subsets: Protozoology
N2  - This review covers: management of ocular toxoplasmosis; mode of action and pharmacokinetics of sulfonamides and antifolate drugs; pyrimethamine-sulfonamide combinations; trimethoprim-sulfonamide combinations; miscellaneous sulfonamides; antibiotic therapy of toxoplasmosis (spiramycin, clindamycin, clindamycin-pyrimethamine combinations, roxithromycin, azithromycin); robenidine; trimetrexate and related compounds; purine analogues; miscellaneous derivatives with antitoxoplasma activity; role of cell-mediated immunity in the therapy of toxoplasmosis; drug-resistant mutants of Toxoplasma gondii.
KW  - antiprotozoal agents
KW  - drug therapy
KW  - human diseases
KW  - parasites
KW  - reviews
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - chemotherapy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804403&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anaphylactoid reaction with suramin.
AU  - Thibault, A.
AU  - Figg, W. D.
AU  - Cooper, M. R.
AU  - Prindiville, S. A.
AU  - Sartor, A. O.
AU  - Headlee, D. J.
AU  - Myers, C. E.
JO  - Pharmacotherapy
JF  - Pharmacotherapy
Y1  - 1993///
VL  - 13
IS  - 6
SP  - 656
EP  - 657
SN  - 0277-0008
AD  - Thibault, A.: Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803227.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 145-63-1.  Subject Subsets: Protozoology; Helminthology
N2  - A 73-year-old man had an anaphylactoid reaction following the first dose of suramin (15.9 mg/kg, total dose 1500 mg infused over 1 h, given as a treatment for metastatic prostate cancer). It was treated successfully with epinephrine, diphenhydramine, and hydrocortisone.
KW  - anaphylaxis
KW  - helminths
KW  - parasites
KW  - suramin
KW  - toxicity
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - anaphylactic reactions
KW  - anaphylactic shock
KW  - parasitic worms
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803227&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - New tetrahydrobiopterin-dependent systems.
AU  - Kaufman, S.
JO  - Annual Review of Nutrition
JF  - Annual Review of Nutrition
Y1  - 1993///
VL  - 13
SP  - 261
EP  - 286
SN  - 0199-9885
AD  - Kaufman, S.: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941406248.  Publication Type: Journal Article.  Language: English.  Number of References: 119 ref. Registry Number: 22150-76-1.  Subject Subsets: Human Nutrition
N2  - This review of the role played by tetrahydrobiopterin-dependent systems covers the following areas: Role of tetrahydrobiopterin (BH4) as the coenzyme for the aromatic amino acid hydroxylases; Phenylketonuria and its variants; BH4 and cell proliferation; BH4 and cell-mediated immunity; and BH4 as a neurotransmitter-releasing factor.
KW  - amino acid metabolism
KW  - biopterin
KW  - cell mediated immunity
KW  - cells
KW  - coenzymes
KW  - growth
KW  - hyperphenylalaninaemia
KW  - neurotransmitters
KW  - phenylketonuria
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cellular immunity
KW  - hyperphenylalaninemia
KW  - Phenylalanine hydroxylase deficiency
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406248&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A TH1-&gt;TH2 switch is a critical step in the etiology of HIV infection.
AU  - Clerici, M.
AU  - Shearer, G. M.
JO  - Immunology Today
JF  - Immunology Today
Y1  - 1993///
VL  - 14
IS  - 3
SP  - 107
EP  - 111
SN  - 0167-4919
AD  - Clerici, M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020571.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Public Health
N2  - The authors propose, from their work and others', that TH1-type responses are immunoprotective and that seroconversion and detection of viral DNA in blood cells correlates with a transition from a preliminary TH1 state to a TH2 bias in response to HIV. The implications for vaccine strategies are discussed; low-dose immunization, preferentially inducing cellular immunity, may be advantageous.
KW  - Cell mediated immunity
KW  - Cytokines
KW  - disease course
KW  - HIV infections
KW  - Immunology
KW  - interleukins
KW  - Regulation
KW  - research
KW  - T lymphocytes
KW  - vaccines
KW  - cellular immunity
KW  - disease progression
KW  - Helper T cells
KW  - helper T-cell function
KW  - human immunodeficiency virus infections
KW  - Immune function
KW  - studies
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Research (AA500) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020571&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice.
AU  - Luca, L. M. de
AU  - Sly, L.
AU  - Jones, C. S.
AU  - Chen, L. C.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1993///
VL  - 14
IS  - 3
SP  - 539
EP  - 542
SN  - 0143-3334
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19941404928.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - A study was conducted to evaluate the effect of dietary retinoic acid (RA) on papilloma formation and the conversion of papillomas to carcinomas. Skin tumours were induced in 3 week old female SENCAR mice by an application of 7,12-dimethylbenz(a)anthracene (DMBA) 20 µg, followed by 20 weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) 10 µg. Mice were given RA 0.3 (nutritionally marginal dose), 3 (near physiological) and 30 (pharmacological) µg/g diet. Mice fed RA 30 µg/g diet had the same survival rate as the other 2 groups despite a lower body weight and all groups had similar papilloma incidence, which reached 100% at 18 weeks old. Mice fed on RA 3 µg/g diet had the highest papilloma yield (about 14 papillomas/mouse) and it peaked between 18 and 38 weeks old. These papillomas later regressed such that mice from all groups had about the same papilloma yield at 44 weeks old. Mice fed RA 30 µg/g diet failed to develop any visible carcinoma, while mice fed on 0.3 or 3 µg/g showed 1.9% conversion of papillomas to carcinomas. Therefore, dietary RA at 30 µg/g diet inhibited the conversion of papillomas to carcinomas without affecting papilloma incidence. In addition, dietary RA 30 and 0.3 µg/g diet lowered papilloma yield.
KW  - carcinoma
KW  - intake
KW  - retinoic acid
KW  - skin
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dermis
KW  - tretinoin
KW  - vitamin A acid
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404928&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of varying the onset of exposure to DDT on its modulation of AFB1-induced hepatocarcinogenesis in the rat.
AU  - Rojanapo, W.
AU  - Kupradinum, P.
AU  - Tepsuwan, A.
AU  - Tanyakaset, M.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1993///
VL  - 14
IS  - 4
SP  - 663
EP  - 667
SN  - 0143-3334
AD  - Rojanapo, W.: Biochemistry and Chemical Carcinogenesis Section, National Cancer Institute, Bangkok 10400, Thailand.
N1  - Accession Number: 19931214388.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 50-29-3.  Subject Subsets: Medical & Veterinary Mycology; Medical & Veterinary Entomology
N2  - DDT markedly inhibited hepatocarcinogenesis in rats when administered at the same time as a dose of aflatoxin B1 (AFB1). Giving DDT to rats starting in the middle of AFB1 treatment (1 mg/rat over 8 wk) resulted in a significant enhancement of hepatocarcinogenesis. DDT exhibited a maximum tumour promoting effect when given either 1 or 3 wk after completion of AFB1 treatment, enhancing both the number of animals bearing liver carcinomas and the number of carcinomas per animal. Determination of γ-glutamyltranspeptidase in the serum revealed that the activity increased only in animals bearing big and/or a number of liver carcinomas, especially in those promoted by DDT. It is concluded that DDT acts as an inhibitor of AFB1-induced hepatocarcinogenesis if given prior to or at the same time as the carcinogen, but acts as a tumour promotor if given in the middle of or after the completion of AFB1 treatment.
KW  - Aflatoxins
KW  - carcinogenesis
KW  - DDT
KW  - effects
KW  - Laboratory animals
KW  - liver
KW  - Mycotoxins
KW  - Organochlorine insecticides
KW  - Pesticides
KW  - poisoning
KW  - susceptibility
KW  - toxicity
KW  - Toxicology
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dicophane
KW  - fungal toxins
KW  - toxicosis
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214388&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - Differential effects of dietary β-carotene on papilloma and carcinoma formation induced by an initiation-promotion protocol in SENCAR mouse skin.
AU  - Chen, L. C.
AU  - Sly, L.
AU  - Jones, C. S.
AU  - Tarone, R.
AU  - Luca, L. M. de
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1993///
VL  - 14
IS  - 4
SP  - 713
EP  - 717
SN  - 0143-3334
AD  - Chen, L. C.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19941407380.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 7235-40-7.  Subject Subsets: Human Nutrition
N2  - Sencar mice were used to examine the effects of β-carotene on papilloma formation and the conversion of papillomas to carcinomas in a 2-stage protocol with one application of the initiator 7,12-dimethylbenz[a]anthracene (DMBA, 20 µg) and 20 weekly applications of the promoter 12-O-tetradecanoylphorbol-13-acetate (TPA, 2 µg). A purified vitamin A-free diet was supplemented with β-carotene at 4 concentrations (0.6, 6, 60 and 600 µg/g of diet) for female mice and 2 concentrations (60 and 600 µg/g) for male mice. Dietary supplementations of β-carotene did not result in significant changes in body weight and survival of female and male mice. However, papillomas developed more rapidly and papilloma incidence (percent of mice with papillomas) reached its maximum (100%) sooner in male mice fed on β-carotene 600 µg/g of diet than those fed on 60 µg/g. There were smaller differences in papilloma incidence among the dietary groups in female mice, but the papilloma incidence again reached 100% sooner in mice fed on 600 µg/g. Female and male mice fed on 600 µg had significantly higher papilloma yields (average number of papillomas/mouse) than other dietary groups and a very low percentage of these papillomas converted to carcinomas in these mice. Thus, β-carotene inhibited the conversion of papillomas to carcinomas in both sexes. In addition, papilloma yields were higher in female mice and these papillomas regressed more quickly than those in the corresponding groups of male mice. In conclusion, dietary β-carotene caused differential effects on papilloma formation in female and male SENCAR mice treated with DMBA and TPA in a 2-stage carcinogenesis protocol.
KW  - beta-carotene
KW  - carcinoma
KW  - intake
KW  - skin
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dermis
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407380&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduction in growth temperature minimizes instability of large plasmids containing HIV-1 proviral genomes.
AU  - Joshi, A.
AU  - Jeang, K. T.
JO  - BioTechniques
JF  - BioTechniques
Y1  - 1993///
VL  - 14
IS  - 6
SP  - 880
EP  - 880, 884, 886
AD  - Joshi, A.: Laboratory of Molecular Microbiology, Building 4, Room 306, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005907.  Publication Type: Journal Article.  Language: English. 
KW  - genomes
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - Plasmids
KW  - proviruses
KW  - Stability
KW  - Temperature
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cell culture technique
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005907&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Managing occupational exposures to HIV-1 in the healthcare workplace.
AU  - Fahey, B. J.
AU  - Beekmann, S. E.
AU  - Schmitt, J. M.
AU  - Fedio, J. M.
AU  - Henderson, D. K.
JO  - Infection Control and Hospital Epidemiology
JF  - Infection Control and Hospital Epidemiology
Y1  - 1993///
VL  - 14
IS  - 7
SP  - 405
EP  - 412
SN  - 0899-823X
AD  - Fahey, B. J.: (D.K. Henderson) Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C146, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005946.  Publication Type: Journal Article.  Language: English. 
KW  - Health care workers
KW  - HIV infections
KW  - Occupational transmission
KW  - Psychosocial aspects
KW  - human immunodeficiency virus infections
KW  - Medical care
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Occupational Health and Safety (VV900) 
KW  - Health Services (UU350) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn.
AU  - Ghoshal, A.
AU  - Snyderwine, E. G.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1993///
VL  - 14
IS  - 11
SP  - 2199
EP  - 2203
SN  - 0143-3334
AD  - Ghoshal, A.: Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethseda, MD 20892-0037, USA.
N1  - Accession Number: 19940405483.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Dairy Science; Human Nutrition
N2  - The distribution, DNA adduction and excretion into milk of potent multi-organ carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in lactating female F344 rats with 5-day-old pups. Six h after a single dose (10 mg/kg body wt per os) of radiolabelled IQ, MeIQx or PhIP, radioactivity in lactating dams was highest in the liver and kidney, followed by mammary glands, omental fat and brain tissue. By 24 h after carcinogen administration, all tissues of the dams had significantly reduced levels of radioactivity, except for omental fat which exhibited only a slight change in radioactivity levels between 6 and 24 h. 32P-postlabelling analysis showed that levels of DNA adducts in mammary gland 6 h after dosing were 2.2, 0.7 and 0.2 adducts/107 nucleotides for PhIP, IQ and MeIQx respectively. In contrast, in hepatic DNA, the levels of IQ-adducts (5.5 adducts/107 nucleotides) were 11 times higher than those of PhIP of MeIQx. The stomach contents, liver, kidney and urine of pups nursed by dams which had received radiolabelled IQ, MeIQx or PhIP were radioactive, indicating that these carcinogens (and/or their metabolites) had been excreted into milk and absorbed by the pups. After a 6-h suckling period, the amount of PhIP-derived radioactivity in the stomach contents of the pups was approximately 10 times higher than that seen with IQ or MeIQx. Urine from pups in the 3 groups was mutagenic in the Ames assay with Salmonella TA98 in the presence of an S9 activating system. IQ-, MeIQx- and PhIP-DNA adducts, at levels of 0.25-0.46 adducts/108 nucleotides, were detected in the livers of pups using the 32P-postlabelling method under intensification conditions. These results indicate that milk is a route of exposure of the newborn to heterocyclic amines. The presence of DNA adducts in the tissue of pups further suggests that this route may have a carcinogenic consequence to the newborn.
KW  - carcinogenesis
KW  - carcinogens
KW  - excretion
KW  - heterocyclic nitrogen compounds
KW  - intake
KW  - lactation
KW  - pups
KW  - rat milk
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - rat lactation
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regressive and non-regressive thyroid lesions of the rat induced by single injection of N-bis(2-hydroxypropyl)nitrosamine and iodine deficient diet.
AU  - Kanno, J.
AU  - Maronpot, R. R.
AU  - Takahashi, M.
AU  - Kasuga, T.
AU  - Hayashi, Y.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1993///
VL  - 14
IS  - 11
SP  - 2389
EP  - 2396
SN  - 0143-3334
AD  - Kanno, J.: Laboratory of Experimental Pathology, Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19941411222.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 7553-56-2.  Subject Subsets: Human Nutrition
N2  - 6-week-old male F344 rats were divided into 4 groups. Rats in groups 1 (n = 16) and 3 (n = 14) received a subcutaneous injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN) (2800 mg/kg) in experimental week 1 while rats in groups 2 (n = 5) and 4 (n = 5) received saline. From weeks 2-20, all rats were given an iodine deficient (I-def) diet and tap water. Groups 1 and 2 were killed for the measurements of thyroid-stimulating hormone (TSH), thyroxine (T4), the maximum thyroid width (MTW), thyroid weight, morphology, morphometrics and proliferating cell nuclear antigen (PCNA) labelling index (LI). The thyroids of the rats in group 3 and 4 were surgically exposed and the MTW's were measured. These latter rats were given basal diet for 6 weeks to recover from I deficiency, and then killed for the same measurements. Thyroid nodular lesions in group 1 rats were classified into 5 categories (NL0, NL1, NL2 NL3 and NL4) based upon incremental cellular and structural atypia. 2 types of regressive nodules (NL′0 and NL′1+2) were identified in the recovered rats as the regressed form of NL0, NL1 and NL2 lesions. NL3 and NL4 nodules were seen in groups 1 and 3. The mean number of combined NL0, NL1 or NL2 lesions was 28.44±6.12 nodules per rat (NPR) in group 1 rats and the mean number of NL′0 and NL′1+2 lesions was 28.07±13.05 NPR in group 3 rats. The mean number of NL3 or NL4 lesions was 1.70 NPR in group 1 rats and 3.42 NPR in group 3 rats. The LIs were NL0 (6.4±2.5%), NL1 (7.7±4.4%), NL2 (0.7±0.3%), NL3 (7.5 ±1.3%) and NL4 (14.4±5.3%) in group 1 rats and NL′0 (&lt;0.001%), NL′1+2 (&lt;0.01%), NL3 (9.0±4.4%) and NL4 (23.3±17.8%) in group 3 rats. The thyroid weights of group 4 rats were 41% of group 2 rats. The volume fraction (VF) of the non-NL3, non-NL4 areas in group 3 rats was 40% of that in group 1 rats. However, the VF of NL3 or NL4 lesions in group 3 rats was 520% of that of group 1 rats. In summary, the growth of the NL0, NL1 and NL2 lesions was TSH-dependent, whereas NL3 and NL4 lesions were TSH-independent. In conclusion, affirmative morphological criteria were established to determine growth dependency on sustained serum TSH for thyroid nodular lesions induced in F344 rats by DHPN and I-def diet.
KW  - deficiency
KW  - iodine
KW  - lesions
KW  - nitrosamines
KW  - thyroid gland
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - thyroid
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adenocarcinomas of the uterine cervix: the epidemiology of an increasing problem.
AU  - Kruger Kjaer, S.
AU  - Brinton, L. A.
JO  - Epidemiologic Reviews
JF  - Epidemiologic Reviews
Y1  - 1993///
VL  - 15
IS  - 2
SP  - 486
EP  - 498
SN  - 0193-936X
AD  - Kruger Kjaer, S.: (L.A. Brinton) Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028134.  Publication Type: Journal Article.  Language: English.  Number of References: 75 ref. Subject Subsets: Public Health
N2  - A review.
KW  - cervix
KW  - epidemiology
KW  - neoplasms
KW  - reviews
KW  - cancer sites
KW  - cancers
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The medicinal leech as a source of infection.
AU  - Fedorko, D. P.
JO  - Clinical Microbiology Newsletter
JF  - Clinical Microbiology Newsletter
Y1  - 1993///
VL  - 15
IS  - 21
SP  - 164
EP  - 165
SN  - 0196-4399
AD  - Fedorko, D. P.: Clinical Pathology Department, Building 10, Room 2C-385, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942025103.  Publication Type: Journal Article; Editorial; Journal article.  Language: English.  Number of References: 13 ref. Subject Subsets: Helminthology; Protozoology; Public Health
N2  - A short overview.
KW  - disease transmission
KW  - human diseases
KW  - infectious diseases
KW  - parasites
KW  - reviews
KW  - transmission
KW  - Hirudo medicinalis
KW  - man
KW  - protozoa
KW  - Trypanosoma cruzi
KW  - Hirudo
KW  - Hirudidae
KW  - Hirudinea
KW  - Annelida
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - communicable diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Association between Rochalimaea infection and cat-scratch disease.
AU  - Gradon, J. D.
AU  - Stein, D. S.
AU  - Schwartzmann, W. A.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1993///
VL  - 17
IS  - 2
SP  - 287
EP  - 288
SN  - 1058-4838
AD  - Gradon, J. D.: Medical Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
N1  - Accession Number: 19950503164.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref.
N2  - Reference is made to the article by W.A. Schwartzmann (1992) [Clinical Infectious Diseases, 15: 893-902] on R. henselae [Bartonella henselae] in the aetiology of cat-scratch disease. Dr Schwartzmann replies.
KW  - aetiology
KW  - human diseases
KW  - Bartonella henselae
KW  - man
KW  - Bartonella
KW  - Bartonellaceae
KW  - Rhizobiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - cat-scratch disease
KW  - causal agents
KW  - etiology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - MRI of choroidal plexus involvement in intracranial cryptococcosis.
AU  - Patronas, N. J.
AU  - Makariou, E. V.
JO  - Journal of Computer Assisted Tomography
JF  - Journal of Computer Assisted Tomography
Y1  - 1993///
VL  - 17
IS  - 4
SP  - 547
EP  - 550
SN  - 0363-8715
AD  - Patronas, N. J.: Department of Radiology, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200843.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Two cases of central nervous system Cryptococcus neoformans infection are reported in 45- and 37-yr-old HIV-negative women from Maryland, USA. In both cases magnetic resonance imaging demonstrated the involvement of the ventricles and the choroid plexuses. The choroid plexuses were unusually enlarged and intensely enlarged. Intraventricular loculations were also noted including entrapment of cerebrospinal fluid in the temporal horns. Both patients recovered after treatment with amphotericin B and amphotericin B followed by fluconazole, respectively.
KW  - case reports
KW  - central nervous system
KW  - cryptococcosis
KW  - diagnosis
KW  - hosts
KW  - human diseases
KW  - infections
KW  - magnetic resonance imaging
KW  - Maryland
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - CNS
KW  - european blastomycosis
KW  - fungus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immune-based therapeutics: scientific rationale and the promising approaches to the treatment of the human immunodeficiency virus-infected individual.
AU  - Stein, D. S.
AU  - Timpone, J. G.
AU  - Gradon, J. D.
AU  - Kagan, J. M.
AU  - Schnittman, S. M.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1993///
VL  - 17
IS  - 4
SP  - 749
EP  - 771
SN  - 1058-4838
AD  - Stein, D. S.: (S.M. Schnittman) Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Rockville, MD 20892, USA.
N1  - Accession Number: 19932004636.  Publication Type: Journal Article.  Language: English.  Number of References: 195 ref.
KW  - Cytokines
KW  - HIV infections
KW  - Immunomodulators
KW  - immunopathology
KW  - passive immunization
KW  - Treatment
KW  - Vaccines
KW  - Adoptive cellular immunotherapy
KW  - human immunodeficiency virus infections
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A new approach for estimating healthy body weights.
AU  - Garrison, R. J.
AU  - Kannel, W. B.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1993///
VL  - 17
IS  - 7
SP  - 417
EP  - 423
SN  - 0307-0565
AD  - Garrison, R. J.: Field Studies and Biometry Branch, Epidemiology and Biometry Program, Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19941404217.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Human Nutrition
N2  - A strategy based on a more direct measure of adiposity, subscapular skinfolds and cardiovascular disease risk factors, rather than mortality for the estimation of body weight is discussed. This approach provides a means for estimating standards that are consistent with optimum cardiovascular health without the lengthy follow-up required for mortality studies. Data on 2447 non-smoking men and women, 20 to 59 years old is used. 7 cardiovascular disease risk factors were significantly related to subscapular skinfold thickness in both sexes in an unfavourable direction. Optimal subscapular skinfolds based on these risk factors for 20 to 39 year-olds were estimated to be &lt;12 for men and 15 mm for women. Men and women who had subscapular skinfolds at or below the optimal level had a mean body mass index (BMI) of 22.6 and 21.1 kg/m², respectively. The probability of being above the optimum adiposity rises rapidly across BMI levels &gt;20 kg/m² and plateaus at above 0.90 in both men and women with BMI &gt;24 km/m². Thus, screening for above optimal adiposity is necessary only in individuals with BMI at or &lt;24 kg/m².
KW  - anthropometric dimensions
KW  - assessment
KW  - body composition
KW  - body measurements
KW  - body weight
KW  - cardiovascular diseases
KW  - estimation
KW  - risk
KW  - standards
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anthropometric measurements
KW  - Laws and Regulations (DD500) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Decreased physical activity in Pima Indian compared with Caucasian children.
AU  - Fontvieille, A. M.
AU  - Kriska, A.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1993///
VL  - 17
IS  - 8
SP  - 445
EP  - 452
SN  - 0307-0565
AD  - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19941404220.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - The relation between physical activity and body composition was examined in 43 Pima Indians (22 boys, 21 girls; 9.9±1.1 years old) and 42 Caucasians (21 boys, 21 girls; 9.7±1.2 years old). A list of usual sport leisure activities was established (bicycling, swimming, basketball) and subjects were asked how much time they had devoted to each activity over the past week and the last year. Data on time spent playing outside (excluding sport leisure activities for estimation of physical activity) and watching television/videos were also collected. Pima Indians were taller (143±9 vs. 137±8 cm, P&lt;0.001), heavier (48.6±15.8 vs. 32.9±7.8 kg, P&lt;0.0001) and fatter (39±16 vs. 24±7% fat, P&lt;0.001) than Caucasians. Pima Indian girls showed lower past year and past week sport leisure activity than Caucasian girls (P&lt;0.01) and spent more time watching television/videos (P&lt;0.05). Pima boys showed lower past week sport leisure activity than Caucasian boys (P&lt;0.05). In Pima Indian boys, past year sport leisure activity correlated negatively (P&lt;0.05) with body mass index (r = -0.49) and percentage body fat (r = -0.56). However, such correlations were not found in Pima Indian girls, possibly due to their very low levels of activity. Even though cause and effect cannot be distinguished in cross-sectional studies, findings suggest that decreased physical activity and increased television viewing may contribute to development of obesity in Pima Indian children.
KW  - American Indians
KW  - body composition
KW  - body fat
KW  - children
KW  - ethnic groups
KW  - obesity
KW  - physical activity
KW  - television
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy cost of arousal: effect of sex, race and obesity.
AU  - Fontvieille, A. M.
AU  - Ferraro, R. T.
AU  - Rising, R.
AU  - Larson, D. E.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1993///
VL  - 17
IS  - 12
SP  - 705
EP  - 709
SN  - 0307-0565
AD  - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
N1  - Accession Number: 19941408466.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - The basal (BMR) to sleeping metabolic rate (SMR) ratio might represent an estimate of the activation of the nervous system (central/sympathetic) from sleeping to basal state. 24-h energy expenditure (24EE), BMR and SMR were measured in a respiratory chamber in Caucasians (63 men/59 women 32±10 years old, 94±33 kg, 29±11% fat) and in Pima Indians (68 men/55 women 29±7 years old, 100±25 kg, 34±9% fat). The BMR/SMR ratio varied greatly between individuals (1.05±0.08; range 0.87 to 1.34). In Pima Indians, BMR/SMR was inversely correlated to both fat mass (r = -0.26; P&lt;0.01) and BMI (r = -0.22; P&lt;0.05), whereas, in Caucasians, BMR/SMR was inversely correlated to waist/thigh circumference ratio (r = -0.28; P&lt;0.01). On average, the BMR/SMR was higher in Pima Indians than in Caucasians (1.06±0.08 vs. 1.03±0.07, P&lt;0.01) and higher in Pima Indian men than in Pima Indian women (1.08±0.09 vs. 1.04±0.06, P&lt;0.05).
KW  - body composition
KW  - energy exchange
KW  - energy metabolism
KW  - ethnic groups
KW  - metabolism
KW  - obesity
KW  - sex differences
KW  - sympathetic nervous system
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Metabolic predictors of obesity: cross-sectional versus longitudinal data.
AU  - Ravussin, E.
AU  - Swinburn, B. A.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1993///
VL  - 17
IS  - SUP 3
SP  - S28
EP  - S31
SN  - 0307-0565
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Suite 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19941404195.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - The effect of energy expenditure, spontaneous physical activity, respiratory quotient and insulin sensitivity on weight gain in the Pima Indians of Arizona, USA, are reviewed.
KW  - body composition
KW  - energy exchange
KW  - ethnic groups
KW  - insulin
KW  - metabolism
KW  - obesity
KW  - physical activity
KW  - respiratory quotient
KW  - reviews
KW  - weight gain
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - sensitivity
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404195&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevention of invasive fungal infections in patients with neoplastic diseases.
AU  - Walsh, T. J.
AU  - Lee, J. W.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1993///
VL  - 17
IS  - Suppl. 2
SP  - S468
EP  - S480
SN  - 1058-4838
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941202079.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 124 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - Strategies for the prevention of invasive mycoses in granulocytopenic and other immunocompromised patients with neoplastic diseases are reviewed. Defining strategies are discussed for prevention of invasive Candida infections with imidazoles, triazoles, orally administered polyenes and intravenously and empirically administered amphotericin B, and for invasive Aspergillus infections with triazoles, intranasal amphotericin B, low-dose amphotericin B, secondary prophylaxis and environmental measures. Problems in utilizing antifungal chemoprophylaxis, including selection of patients for antifungal prophylaxis, duration of treatment, drug interactions, techniques for early diagnosis and the emergence of resistant fungi, and future directions of antifungal therapy such as new antifungal agents and the use of recombinant human cytokines and peripheral stem cells are also considered.
KW  - amphotericin B
KW  - antifungal agents
KW  - aspergillosis
KW  - candidosis
KW  - drug therapy
KW  - human diseases
KW  - imidazoles
KW  - immunocompromised hosts
KW  - infections
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - prophylaxis
KW  - triazoles
KW  - Aspergillus
KW  - Candida
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - cancers
KW  - candidiasis
KW  - chemotherapy
KW  - Controversies in the management of infections in immunocompromised patients
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - polyenes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941202079&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of the herbicide atrazine in the development of non-Hodgkin's lymphoma.
AU  - Hoar Zahm, S.
AU  - Weisenburger, D. D.
AU  - Cantor, K. P.
AU  - Holmes, F. F.
AU  - Blair, A.
JO  - Scandinavian Journal of Work, Environment & Health
JF  - Scandinavian Journal of Work, Environment & Health
Y1  - 1993///
VL  - 19
IS  - 2
SP  - 108
EP  - 114
SN  - 0355-3140
AD  - Hoar Zahm, S.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Rockville, MD 20892, USA.
N1  - Accession Number: 19942026228.  Publication Type: Journal Article.  Language: English.  Registry Number: 1912-24-9.  Subject Subsets: Public Health
N2  - Atrazine is the most commonly used herbicide in the United States and is a wide-spread groundwater contaminant in the Midwest. The role of atrazine in the development of human non-Hodgkin's lymphoma (NHL) was investigated in three case-referent studies conducted in four midwestern states in the United States. A total of 993 white men with NHL and 2918 population-based referents were interviewed concerning their agricultural practices. When the results of the three studies were combined, atrazine use was associated with an odds ratio of 1.4 [95% confidence interval (95% CI) 1.1-1.8, 130 cases, 249 referents] for NHL. However, adjustments for the use of 2,4-dichlorophenoxyacetic acid and organophosphate insecticides reduced the apparent association between NHL and atrazine in all but one state and reduced the associations for the long-term and frequent users in Nebraska. Detailed analyses suggested that there was little or no increase in the risk of NHL attributable to the agricultural use of atrazine.AS/R.D. Verschoyle
KW  - atrazine
KW  - exposure
KW  - herbicides
KW  - Non-Hodgkin's lymphoma
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - United States of America
KW  - weedicides
KW  - weedkillers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A comparison of diets of blacks and whites in three areas of the United States.
AU  - Swanson, C. A.
AU  - Gridley, G.
AU  - Greenberg, R. S.
AU  - Schoenberg, J. B.
AU  - Swanson, G. M.
AU  - Brown, L. M.
AU  - Hayes, R.
AU  - Silverman, D.
AU  - Pottern, L.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1993///
VL  - 20
IS  - 2
SP  - 153
EP  - 165
SN  - 0163-5581
AD  - Swanson, C. A.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001413211.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Dietary factors may contribute to the increased cancer risk of blacks. As a first step to explore this hypothesis, we examined food frequency data obtained by interview with 1976 adults (881 blacks and 1095 whites) randomly selected from three areas (New Jersey, Detroit, Atlanta) of the United States. The a priori hypothesis was that blacks were more likely to consume diets low in fruits and vegetables and/or high in fat, particularly saturated fat. Contrary to expectation, blacks were more frequent consumers of fruits and vegetables considered to be protective against cancer (citrus fruits, cruciferous vegetables, and vegetables rich in vitamins A and C). Intake of both total and saturated fat was slightly lower among blacks than whites. This analysis does not rule out a role for these dietary factors in the aetiology of cancer but indicates that ascribing the excess cancer risk among blacks to their frequency of fruit and vegetable consumption or intake of fat per se is inadequate. This suggests that alternative dietary explanations for the racial disparity in cancer risk should be pursued in future studies.
KW  - aetiology
KW  - blacks
KW  - Caucasian
KW  - citrus fruits
KW  - consumers
KW  - diet studies
KW  - diets
KW  - ethnic groups
KW  - ethnicity
KW  - fruits
KW  - intake
KW  - neoplasms
KW  - protection
KW  - questionnaires
KW  - retinol
KW  - risk factors
KW  - saturated fats
KW  - vegetables
KW  - vitamins
KW  - USA
KW  - Brassicaceae
KW  - Citrus
KW  - man
KW  - Capparidales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Rutaceae
KW  - Sapindales
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - cancers
KW  - Capparales
KW  - causal agents
KW  - ethnic differences
KW  - etiology
KW  - Rutales
KW  - United States of America
KW  - vegetable crops
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary factors and survival from breast cancer.
AU  - Rohan, T. E.
AU  - Hiller, J. E.
AU  - McMichael, A. J.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1993///
VL  - 20
IS  - 2
SP  - 167
EP  - 177
SN  - 0163-5581
AD  - Rohan, T. E.: National Cancer Institute of Canada (NCIC) Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
N1  - Accession Number: 20001413212.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 50-81-7, 7235-40-7.  Subject Subsets: Human Nutrition
N2  - The association between self-reported intake of various dietary factors at diagnosis and survival from breast cancer was studied in a population-based cohort of breast cancer patients in Adelaide, South Australia. These patients had been recruited between 1982 and 1984 into a case-control study of diet and incident breast cancer. Of the 451 patients recruited originally, 412 were followed for a median interval of 5.5 years. There were decreases in the risk of death from breast cancer ranging from 25 to 40% at all levels of energy and protein intake above the baseline, whereas for fat intake there was a 40% increase in risk at the uppermost quintile level. There was also some reduction in risk at the upper levels of intake of β-carotene and vitamin C. However, there were no dose-dependent variations in risk of death by level of intake for any of the dietary factors studied, and most of the variation in risk that was observed was relatively insubstantial.
KW  - ascorbic acid
KW  - beta-carotene
KW  - breast cancer
KW  - diagnosis
KW  - diet studies
KW  - diets
KW  - energy consumption
KW  - intake
KW  - mammary glands
KW  - mortality
KW  - neoplasms
KW  - protein intake
KW  - risk factors
KW  - variation
KW  - women
KW  - Australia
KW  - South Australia
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - Australia
KW  - cancers
KW  - death rate
KW  - energy use
KW  - energy utilization
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413212&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A Borrelia burgdorferi homolog of the Escherichia coli rho gene.
AU  - Tilly, K.
AU  - Campbell, J.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1993///
VL  - 21
IS  - 4
SP  - 1040
EP  - 1040
SN  - 0305-1048
AD  - Tilly, K.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950502652.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - Borrelia burgdorferi
KW  - Escherichia coli
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - E. coli
KW  - gene homologue
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502652&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fidelity of DNA synthesis catalyzed by human DNA polymerase α and HIV-1 reverse transcriptase: effect of reaction pH.
AU  - Eckert, K. A.
AU  - Kunkel, T. A.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1993///
VL  - 21
IS  - 22
SP  - 5212
EP  - 5220
SN  - 0305-1048
AD  - Eckert, K. A.: (T.A. Kunkel) National Institute of Environmental Health Sciences, Laboratory of Molecular Genetics, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19942025762.  Publication Type: Journal Article.  Language: English.  Registry Number: 9012-90-2. 
KW  - Biochemistry
KW  - DNA polymerase
KW  - Gene expression
KW  - human immunodeficiency viruses
KW  - Molecular biology
KW  - PH
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Error rate
KW  - Fidelity
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - hydrogen ion concentration
KW  - potential of hydrogen
KW  - Reverse transcriptase activity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025762&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Physical activity and occupational risk of colon cancer in Shanghai, China.
AU  - Chow, W. H.
AU  - Dosemeci, M.
AU  - et al.
AU  - Zheng, W. (
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1993///
VL  - 22
IS  - 1
SP  - 23
EP  - 29
SN  - 0300-5771
AD  - Chow, W. H.: National Cancer Institute, 6130 Executive Blvd., EPN 415, Rockville, MD 20892, USA.
N1  - Accession Number: 19932020376.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Using occupational data for over 2000 colon cancer cases diagnosed between 1980 and 1984 in Shanghai, and employment information from the 1982 census for the Shanghai population, standardized incidence ratios (SIR) were computed for occupational groups classified by job types and physical activity levels. Men employed in occupations with low physical activity levels had modest but significantly elevated risks of colon cancer. SIR for jobs with low activity based on sitting time was 121 (95% confidence interval, CI: 108-135) and based on energy expenditure was 126 (95% CI: 115-138). Corresponding SIR for women were 99 (95% CI: 83-118) and 113 (95% CI: 100-127). The data were also used to screen for specific occupations with elevated SIR to generate leads to occupational colon cancer. Increased incidence was observed for professional and other white collar workers, and male chemical processors and female textile workers. The findings add to the emerging evidence that workplace activity may influence the risk of this common cancer.AS
KW  - colon
KW  - neoplasms
KW  - occupational hazards
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020376&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Community-based intervention: the coronary risk factor study (CORIS).
AU  - Rossouw, J. E.
AU  - Jooste, P. L.
AU  - et al.
AU  - Chalton, D. O. (
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1993///
VL  - 22
IS  - 3
SP  - 428
EP  - 438
SN  - 0300-5771
AD  - Rossouw, J. E.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932022603.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - The Coronary Risk Factor Study (CORIS) examined the feasibility and effectiveness of a multifactorial community intervention programme to reduce coronary heart disease (CHD) risk factor levels. Three Afrikaner communities were surveyed before and after a 4-year intervention in two of the communities, the third serving as a control (C). Intervention was primarily by small mass media (low-intensity intervention, LII) or by small mass media plus interpersonal intervention to high-risk individuals (high-intensity intervention, HII). After allowing for change in C, significant net reductions in blood pressure, smoking, and risk score were obtained in LII and HII alike. Though the total cholesterol (TC) fell by 10-12%, there was no net reduction in favour of the intervention communities. However, LII and HII resulted in significant increases in high-density lipoprotein cholesterol (HDL-C) levels and HDL-C/TC ratios in comparison to C. Overall, the LII community fared almost as well as the HII community, and high-risk individuals did not show a greater change in risk factors than others. [The authors] conclude that community-based intervention works, and that in these particular communities a media-based health education programme was more cost-effective than one which adds a greater degree of interpersonal intervention.AS
KW  - heart diseases
KW  - intervention
KW  - myocardial ischaemia
KW  - Africa
KW  - South Africa
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Southern Africa
KW  - Africa South of Sahara
KW  - Threshold Countries
KW  - coronary diseases
KW  - ischaemic heart disease
KW  - myocardial ischemia
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022603&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Youth tobacco use in the United States-problem, progress, goals, and potential solutions.
AU  - Glynn, T. J.
AU  - Greenwald, P.
AU  - Mills, S. M.
AU  - Manley, M. W.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1993///
VL  - 22
IS  - 4
SP  - 568
EP  - 575
SN  - 0091-7435
AD  - Glynn, T. J.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 243, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19942023912.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - adolescents
KW  - children
KW  - Tobacco smoking
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - teenagers
KW  - United States of America
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942023912&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The design and analysis of cholera vaccine trials: recent lessons from Bangladesh.
AU  - Clemens, J.
AU  - Sack, D.
AU  - et al.
AU  - Rao, M. (
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1993///
VL  - 22
IS  - 4
SP  - 724
EP  - 730
SN  - 0300-5771
AD  - Clemens, J.: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, G100 Executive Blvd., Bethesda, MD 20892, USA.
N1  - Accession Number: 19932023301.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - The recent spread of cholera to Latin America, together with the persistent burden of this disease in Asia and Africa, have stimulated efforts to evaluate new cholera vaccines in field settings. Although the standard experimental paradigm for vaccine field trials is well established, the success of these trials will also depend on suitable consideration of the epidemiology of cholera and of cholera vaccination in the settings under study. Epidemiological studies done in Bangladesh emphasize the importance of appreciating the poorly predictable, multifocal occurrence of cholera in estimating a probable incidence of cholera for a field trial. They also underscore how the filtering effect of enrolling subjects into a prospective trial can dramatically reduce the available population for study, and can yield a study sample whose expected risk of cholera differs markedly from that for the source population. Finally, the data highlight the subtle effects that the mode of surveillance and the choice of an outcome definition can have upon protective efficacy, and emphasize the need for subgroup analyses that address the distinctive variations in vaccine protection that may occur in subjects differing in age and in ABO blood groups, and in subjects exposed to classical versus El Tor cholera. [There is no mention of the known serotype-specificity of immunity to cholera-which demands that cholera vaccine produce a balanced response to the Inaba and Ogawa serotypes. Also, because the paper was written before reports of the epidemic and pandemic potential of a third (Bengal) serotype of cholera vibrio, the need for this third component in future cholera vaccines is not recognized.] N.W. Preston
KW  - Cholera
KW  - inactivated vaccines
KW  - trials
KW  - Asia
KW  - Bangladesh
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - killed vaccines
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023301&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer mortality among jewelry workers.
AU  - Hayes, R. B.
AU  - Dosemeci, M.
AU  - Riscigno, M.
AU  - Blair, A.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1993///
VL  - 24
IS  - 6
SP  - 743
EP  - 751
SN  - 0271-3586
AD  - Hayes, R. B.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942027646.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The mortality of 1009 male members of a New York, USA, jewellery workers union was investigated for the period 1950-1980, and for the years 1984-1989 among 919 men and 605 women, from 24 states in the USA, identified as jewellery workers on death certificates. "This study suggests that workers in the jewellery industry may be at excess risk for malignancies of the digestive system. Excesses were noted for oesophageal cancer in 24 states, due largely to an excess among Rhode Island jewellery workers. Stomach cancer mortality was strikingly in excess for women in the jewellery industry in 24 states. Colon cancer excesses were identified for jewellery workers in New York and in the 24 states. Further analysis of colon cancer indicated that the excesses identified in the 24 states were due to increased proportional mortality in 23 states, excluding Rhode Island. Valerie A. Pritchard
KW  - mortality
KW  - neoplasms
KW  - occupational health
KW  - Occupations
KW  - workers
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - death rate
KW  - jewellers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027646&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer among migrant and seasonal farmworkers: an epidemiologic review and research agenda.
AU  - Zahm, S. H.
AU  - Blair, A.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1993///
VL  - 24
IS  - 6
SP  - 753
EP  - 766
SN  - 0271-3586
AD  - Zahm, S. H.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Rockville, MD 20892, USA.
N1  - Accession Number: 19942027619.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Public Health
KW  - agriculture
KW  - farm workers
KW  - migrants
KW  - neoplasms
KW  - occupational health
KW  - Occupations
KW  - reviews
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Opportunistic infections: treatment and developmental therapeutics of cryptosporidiosis and isosporiasis.
AU  - Georgiev, V. S.
JO  - Drug Development Research
JF  - Drug Development Research
Y1  - 1993///
VL  - 28
IS  - 4
SP  - 445
EP  - 459
SN  - 0272-4391
AD  - Georgiev, V. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 4C-39, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950806050.  Publication Type: Journal Article.  Language: English.  Number of References: 203 ref. Subject Subsets: Protozoology
N2  - This review critically examines cryptosporidiosis and isosporiasis. Although associated with many animal species, Cryptosporidium spp. and Isospora belli are also pathogenic in man. In immunocompetent hosts, the infections are usually self-limited, flu-like gastrointestinal disorders which resolve spontaneously. However, in immunocompromised hosts, cryptosporidiosis is a severe, debilitating, and prolonged illness, with high morbidity and no known effective therapy against it. Immunotherapy is being actively pursued as one potentially useful approach for the treatment of cryptosporidiosis. Azithromycin, a new macrolide antibiotic, has also shown promise in preclinical studies. In the case of isosporiasis, the combination of trimethoprim and sulfamethoxazole has been found to be effective, although HIV patients have shown a high rate of relapse and, therefore, the need for suppressive maintenance therapy.
KW  - acquired immune deficiency syndrome
KW  - cryptosporidiosis
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - immunotherapy
KW  - isosporiasis
KW  - opportunistic infections
KW  - parasites
KW  - reviews
KW  - Cryptosporidium
KW  - Isospora belli
KW  - man
KW  - protozoa
KW  - Cryptosporidiidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Isospora
KW  - Eimeriidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - AIDS
KW  - chemotherapy
KW  - general account
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Does diet provide adequate amounts of calcium, iron, magnesium, and zinc in a well-educated adult population?
AU  - Hallfrisch, J.
AU  - Muller, D. C.
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1993///
VL  - 28
IS  - 4/5
SP  - 473
EP  - 483
SN  - 0531-5565
AD  - Hallfrisch, J.: Metabolism Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19951412371.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 7440-70-2, 7439-89-6, 7439-95-4, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - Standard advice from dietitians, nutritionists, and physicians is that if one eats a well-balanced diet containing a variety of foods, supplements are not necessary. Little information is available, especially in those over 75 years old, to determine whether actual diets do provide adequate amounts of these minerals. The participants of the Baltimore Longitudinal Study of Aging, USA provide 7-day records which include vitamin and mineral supplement intakes. Median daily dietary intakes from diet in all 564 subjects and from diet plus supplements in those who use them were analyzed by age group and gender. More women than men took supplements. Median intakes of calcium from diet were below the recommended dietary allowance (RDA) for unsupplemented women and for supplemented women over 60. Approximately 25% of women under 50 and 10% of women over 50 consumed less than two thirds of the RDA for iron from diet. For both men and women, all groups had median diet intakes below the RDA for magnesium. 40% of men and about half of women consumed less than two thirds of the RDA. These results indicate that many people in this well-educated, presumably well-nourished population did not consume adequate amounts of calcium, iron, magnesium, and zinc from diet. More women than men are at risk. Even those taking supplements did not consume adequate levels of some minerals.
KW  - aging
KW  - calcium
KW  - diet studies
KW  - iron
KW  - magnesium
KW  - mineral supplements
KW  - minerals
KW  - old age
KW  - requirements
KW  - supplements
KW  - trace elements
KW  - zinc
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - ageing
KW  - microelements
KW  - United States of America
KW  - Diet Studies (VV110) 
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ER  - 

TY  - JOUR
T1  - Is there any relationship between aluminum and Alzheimer's disease?
AU  - Eichhorn, G. L.
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1993///
VL  - 28
IS  - 4/5
SP  - 493
EP  - 498
SN  - 0531-5565
AD  - Eichhorn, G. L.: National Institutes of Health, National Institute on Aging, Laboratory of Cellular and Molecular Biology, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19951412372.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 7429-90-5.  Subject Subsets: Human Nutrition
N2  - The role of aluminum in Alzheimer's disease (AD) is reviewed. While current data would suggest the lack of a causative role, alterations in the brain and other organ systems caused by AD might increase the penetration of aluminum as well as other metals into the brain and lead to their contribution to such pathological features as neurofibrillar tangles.
KW  - aluminium
KW  - Alzheimer's disease
KW  - brain
KW  - reviews
KW  - trace elements
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - aluminum
KW  - cerebrum
KW  - microelements
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sex ratio and phoretic mites of fleas (Siphonaptera: Pulicidae and Hystrichopsyllidae) on the Nile grass rat (Arvicanthis niloticus) in Kenya.
AU  - Schwan, T. G.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1993///
VL  - 30
IS  - 1
SP  - 122
EP  - 135
SN  - 0022-2585
AD  - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515210.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The sex ratio of fleas and their phoretic mites associated with A. niloticus were studied during 14 months in a grassland community of Lake Nakuru National Park, Kenya. Females of the fleas Dinopsyllus lypusus, Ctenophthalmus calceatus cabrius and Xenopsylla cheopis bantorum infested more grass rats and in greater numbers than did males. Phoretic hypopi (heteromorphic deutonymphs) of 2 species of mites, Psylloglyphus uilenbergi and Paraceroglyphus xenopsylla, varied seasonally in their abundance on fleas and utilized female fleas over male fleas for their major source of transport. Additionally, the mites were very host specific with nearly 100% of those identified on D. lypusus and C. calceatus cabrius being Psylloglyphus uilenbergi and 89% of the mites identified on X. cheopis bantorum being Paraceroglyphus xenopsylla. This level of specificity suggests that these mite-flea associations are highly evolved. The importance of female fleas as hosts for transporting mites also suggests that female-biased sex ratios of fleas on their hosts may be caused, in part, by females being more important as dispersers within flea populations.
KW  - Ecology
KW  - Ectoparasites
KW  - Hosts
KW  - phoresy
KW  - Population ecology
KW  - Seasonality
KW  - Sex ratio
KW  - Small mammals
KW  - Wild animals
KW  - Africa
KW  - Kenya
KW  - Acari
KW  - Acaridae
KW  - Arachnida
KW  - Arvicanthis niloticus
KW  - Dinopsyllus
KW  - Dinopsyllus lypusus
KW  - Hystrichopsyllidae
KW  - Muridae
KW  - Pulicidae
KW  - Rodents
KW  - Siphonaptera
KW  - WINTERSCHMIDTIIDAE
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Astigmata
KW  - mites
KW  - Acari
KW  - Arvicanthis
KW  - Murinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Siphonaptera
KW  - insects
KW  - Hexapoda
KW  - Ctenophthalmus
KW  - Hystrichopsyllidae
KW  - Dinopsyllus
KW  - Acaridae
KW  - Winterschmidtiidae
KW  - Xenopsylla cheopis
KW  - Xenopsylla
KW  - Pulicidae
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - East Africa
KW  - Africa South of Sahara
KW  - Ctenophthalmus calceatus
KW  - Ctenophthalmus calceatus cabrius
KW  - Paraceroglyphus
KW  - Paraceroglyphus xenopsylla
KW  - Psylloglyphus
KW  - Psylloglyphus uilenbergi
KW  - Saproglyphidae
KW  - Xenopsylla cheopis bantorum
KW  - Biological Resources (Animal) (PP710) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW  - Animal Behaviour (LL300) 
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ER  - 

TY  - JOUR
T1  - Effect of Yersinia pestis infection on temperature preference and movement of the Oriental rat flea (Xenopsylla cheopis) (Siphonaptera: Pulicidae).
AU  - Thomas, R. E.
AU  - Karstens, R. H.
AU  - Schwan, T. G.
JO  - Journal of Medical Entomology
JF  - Journal of Medical Entomology
Y1  - 1993///
VL  - 30
IS  - 1
SP  - 209
EP  - 213
SN  - 0022-2585
AD  - Thomas, R. E.: Laboratory of Vectors and Pathogens, Arthropod-Borne Infectious Diseases Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Public Health Service, 903 South 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930515219.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Previous laboratory studies have shown that inoculation of bacterial endotoxin into the haemocoel of some arthropods, or natural infection by a number of pathogens, causes them to seek out a higher ambient temperature. This phenomenon has been called 'behavioural fever'. Y. pestis is an endotoxin-producing bacterium that relies on infection of fleas for transmission. Behavioural fever in fleas might enhance the transmission of plague if infected fleas were induced to seek out a warm-bodied host after the death of an infected host. Studies indicate that in thermal gradients Y. pestis-infected fleas (X. cheopis) do not exhibit behavioural fever and in one experiment sought out a significantly lower temperature.
KW  - Disease vectors
KW  - Infections
KW  - Temperature
KW  - Enterobacteriaceae
KW  - Pulicidae
KW  - Siphonaptera
KW  - Xenopsylla cheopis
KW  - Yersinia pestis
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Siphonaptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Xenopsylla
KW  - Pulicidae
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - bacterium
KW  - behavioural fever
KW  - Oriental rat flea
KW  - YERSINIA PSEUDOTUBERCULOSIS SUBSP. PESTIS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515219&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - New method for plague surveillance using polymerase chain reaction to detect Yersinia pestis in fleas.
AU  - Hinnebusch, J.
AU  - Schwan, T. H.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1993///
VL  - 31
IS  - 6
SP  - 1511
EP  - 1514
SN  - 0095-1137
AD  - Hinnebusch, J.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940500812.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Tropical Diseases
N2  - Yersinia pestis, the plague bacillus, infects a variety of mammals throughout the world and is transmitted by fleas. A polymerase chain reaction (PCR) test was developed using primers designed from the Y. pestis plasminogen activator gene to directly detect plague-infected fleas. As few as 10 Y. pestis cells were detected, even in the presence of flea tissue, by PCR and then agarose gel electrophoresis and ethidium bromide staining. The feasibility of the assay was demonstrated by using naturally infected Xenopsylla cheopis. The detection of Y. pestis in fleas by PCR provides a rapid and sensitive way to monitor plague in wild animal populations, allowing public health officials to better assess the potential risk of transmission to humans.From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Yersinia pestis, the plague bacillus, infects a variety of mammals throughout the world and is transmitted by fleas. A polymerase chain reaction (PCR) test was developed using primers designed from the Y. pestis plasminogen activator gene to directly detect plague-infected fleas. As few as 10 Y. pestis cells were detected, even in the presence of flea tissue, by PCR and then agarose gel electrophoresis and ethidium bromide staining. The feasibility of the assay was demonstrated by using naturally infected Xenopsylla cheopis. The detection of Y. pestis in fleas by PCR provides a rapid and sensitive way to monitor plague in wild animal populations, allowing public health officials to better assess the potential risk of transmission to humans.
KW  - Detection
KW  - diagnostic techniques
KW  - disease vectors
KW  - Polymerase chain reaction
KW  - Enterobacteriaceae
KW  - Pulicidae
KW  - Siphonaptera
KW  - Xenopsylla cheopis
KW  - Yersinia pestis
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Siphonaptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Xenopsylla
KW  - Pulicidae
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - bacterium
KW  - Oriental rat flea
KW  - PCR
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reactogenicity and immunogenicity of a high-titer rhesus rotavirus-based quadrivalent rotavirus vaccine.
AU  - Flores, J.
AU  - Perez-Schael, I.
AU  - Blanco, M.
AU  - Rojas, A. M.
AU  - Alfonzo, E.
AU  - Crespo, I.
AU  - Cunto, W.
AU  - Pittman, A. L.
AU  - Kapikian, A. Z.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1993///
VL  - 31
IS  - 9
SP  - 2439
EP  - 2445
SN  - 0095-1137
AD  - Flores, J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952004092.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
N2  - The authors evaluated the reactogenicity and antigenicity of a quadrivalent rotavirus vaccine composed of serotype 3 rhesus rotavirus (RRV) and three single-gene-substitution reassortants of RRV and human strain D (D × RRV, serotype 1), DS1 (DS1 × RRV, serotype 2), or ST3 (ST3 × RRV, serotype 4) in a double-masked study with 302 infants in Caracas, Venezuela. Three doses of the quadrivalent vaccine composed of either 105 PFU (low titre) or 106 PFU (high titre) of each component were administered to 99 and 101 infants, respectively, at 4-week intervals starting at the second month of age; 102 infants received a placebo. Postvaccination reactions were monitored by home visits every other day during the week postvaccination. The vaccine was associated with the occurrence of mild, short-lived febrile episodes in 26% and 23% of the recipients after the first doses of high- or low-titre vaccine, respectively, in comparison with 13% of the infants receiving the placebo. Febrile reactions occurred less frequently in vaccinees after the second or third dose than after the initial dose. The vaccine was not significantly associated with diarrhoea or any additional symptom or sign. Serum specimens obtained shortly before the first, 4 weeks after the first, and 4 weeks after the third dose of vaccine or placebo were tested by an immunoglobulin A enzyme-linked immunosorbent assay and by neutralization assays. Seroresponses occurred significantly more often after 3 doses than after a single dose of vaccine or placebo were tested by an immunoglobulin A enzyme-linked immunosorbent assay and by neutralization assays. Seroresponses occurred significantly more often after 3 doses than after a single dose of either vaccine. Immunoglobulin A responses were observed in 80% and 79% of the infants after 3 doses of high- or low-titre vaccine, respectively. Most of the infants tested developed a neutralization response to RRV after 3 doses of the high-(90%) or low-(88%) titre vaccine. Neutralization response rates to human rotavirus serotypes 1 to 4 after 3 doses were similar in both vaccine groups and ranged from 33% to 53%. Overall, 93 of 97 infants receiving the low-titre vaccine and 87 of 90 receiving the high-titre vaccine developed seroresponses, as detected by any of the assays employed. The study indicates that 3 doses of quadrivalent vaccine at a titre of 106 PFU of each component offered no advantage over the lower-titre preparation for use in efficacy trials.
KW  - children
KW  - human diseases
KW  - immunization
KW  - infections
KW  - polyvalent vaccines
KW  - South America
KW  - Venezuela
KW  - man
KW  - rotavirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - America
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - South America
KW  - Threshold Countries
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of a protein in several Borrelia species which is related to OspC of the Lyme disease spirochetes.
AU  - Marconi, R. T.
AU  - Samuels, D. C.
AU  - Schwan, T. G.
AU  - Garon, C. F.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1993///
VL  - 31
IS  - 10
SP  - 2577
EP  - 2583
SN  - 0095-1137
AD  - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940500833.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2  - Using oligonucleotide probes which have previously been shown to be specific for the ospC gene found in the Lyme disease spirochaete species B. burgdorferi, B. garinii and group VS461 [B. afzelii], an ospC homologue was detected in other Borrelia species including B. coriaceae, B. hermsii, B. anserina, B. turicatae and B. parkeri was detected. In contrast to the Lyme disease spirochaetes, which carry the ospC gene on a 26-kb circular plasmid, the gene in other Borrelia species was mapped to linear plasmids which varied in size among the isolates tested. Some isolates carry multiple copies of the gene residing on linear plasmids of different sizes. The analyses conducted also demonstrate that these Borrelia species contain a linear chromosome. Northern (RNA) blot analyses demonstrated that the gene is transcriptionally expressed in all species examined. High levels of transcriptional expression were observed in some B. hermsii isolates. Transcriptional start site analyses revealed that the length of the untranslated leader sequence was identical to that observed in the Lyme disease spirochaete species. By Western blotting (immunoblotting) with antiserum (polyclonal) raised against the OspC protein of B. burgdorferi, an immunoreactive protein of the same molecular weight as the OspC found in Lyme disease spirochaete species was detected. The results presented demonstrate the presence of a protein that is genetically and antigenically related to OspC which is expressed in all species of the genus Borrelia tested.
KW  - antigens
KW  - bacterial diseases
KW  - chromosomes
KW  - gene mapping
KW  - genes
KW  - immunoblotting
KW  - molecular genetics
KW  - plasmids
KW  - proteins
KW  - Borrelia
KW  - Borrelia anserina
KW  - Borrelia burgdorferi
KW  - Borrelia coriaceae
KW  - Borrelia garinii
KW  - Borrelia hermsii
KW  - Borrelia parkeri
KW  - Borrelia turicatae
KW  - Spirochaetaceae
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Borrelia
KW  - antigenicity
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - biochemical genetics
KW  - immunogens
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of microsporidian spores in clinical samples by indirect fluorescent-antibody assay using whole-cell antisera to Encephalitozoon cuniculi and Encephalitozoon hellem.
AU  - Zierdt, C. H.
AU  - Gill, V. J.
AU  - Zierdt, W. S.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1993///
VL  - 31
IS  - 11
SP  - 3071
EP  - 3074
SN  - 0095-1137
AD  - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950807961.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Protozoology
N2  - Three polyclonal mouse antisera (to Encephalitozoon cuniculi, Nosema algerae and N. corneum) and 2 polyclonal rabbit antisera (to E. cuniculi and E. hellem) were used in an indirect immunofluorescence assay (IFA) with E. bieneusi, E. cuniculi and E. hellem spores. Antisera to E. cuniculi and E. hellem reacted strongly and equally with each other's spores. E. bieneusi was easily identified in duodenal and colonic biopsies, duodenal and colonic fluids, and faeces of symptomatic acquired immune deficiency syndrome (AIDS) patients by IFA. In a study of 12 AIDS patients with diarrhoea, the IFA identified Microspora in all of 11 faecal samples, 3 colon fluid samples, 6 duodenal fluid samples and 3 duodenal biopsy samples examined. Although the faecal sample of one patient was negative, the duodenal fluid was positive for microsporan spores by IFA.
KW  - acquired immune deficiency syndrome
KW  - biopsy
KW  - colon
KW  - cross reaction
KW  - diarrhoea
KW  - duodenum
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - immunodiagnosis
KW  - immunofluorescence
KW  - intestinal diseases
KW  - microsporidiosis
KW  - opportunistic infections
KW  - parasites
KW  - patients
KW  - spores
KW  - Encephalitozoon cuniculi
KW  - Encephalitozoon hellem
KW  - man
KW  - protozoa
KW  - Encephalitozoon
KW  - Encephalitozoonidae
KW  - Microspora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - AIDS
KW  - diarrhea
KW  - Encephalitozoon bieneusi
KW  - enteropathy
KW  - fluorescent antibody technique
KW  - human immunodeficiency virus
KW  - IFAT
KW  - scouring
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Distribution and molecular analysis of Lyme disease spirochetes, Borrelia burgdorferi, isolated from ticks throughout California.
AU  - Schwan, T. G.
AU  - Schrumpf, M. E.
AU  - Karstens, R. H.
AU  - Clover, J. R.
AU  - Wong, J.
AU  - Daugherty, M.
AU  - Struthers, M.
AU  - Rosa, P. A.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1993///
VL  - 31
IS  - 12
SP  - 3096
EP  - 3108
SN  - 0095-1137
AD  - Schwan, T. G.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940500838.  Publication Type: Journal Article.  Language: English.  Number of References: 75 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Previous studies describing the occurrence and molecular characteristics of B. burgdorferi from California, USA, have been restricted primarily to isolates obtained from the north coastal region of this large and ecologically diverse state. The objective of this study was to look for and examine B. burgdorferi organisms isolated from Ixodes pacificus ticks collected from numerous regions spanning most parts of California where this tick is found. 31 isolates of B. burgdorferi were examined from individual or pooled I. pacificus ticks collected from 25 countries throughout the state. One isolate was obtained from ticks collected at Wawona Campground in Yosemite National Park, documenting the occurrence of the Lyme disease spirochaete in an area of intensive human recreational use. One isolate from an I. neotomae tick from an additional county (Mendocino) was also examined. SDS-PAGE, immunoblot analysis, agarose gel electrophoresis, Southern blot analysis and the polymerase chain reaction were used to examine the molecular and genetic determinants of these uncloned, low-passage-number isolates. All of the isolates were identified as B. burgdorferi by their protein profiles and reactivities with monoclonal and polyclonal antibodies, and all the isolates were typed by the polymerase chain reaction as North American-type spirochaetes (B. burgdorferi s.s.). Although products of the ospAB locus were identified in protein analysis in all of the isolates, several isolates contained deleted forms of this locus that would result in the expression of chimaeric OspA-OspB proteins. The analysis of OspC demonstrated that this protein was widely conserved among the isolates but was also quite variable in its molecular mass and the amount of it that was expressed.
KW  - antigens
KW  - disease vectors
KW  - DNA
KW  - epidemiology
KW  - immunoblotting
KW  - Lyme disease
KW  - molecular genetics
KW  - national parks
KW  - polymerase chain reaction
KW  - proteins
KW  - SDS-PAGE
KW  - California
KW  - North America
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Ixodes
KW  - Ixodes pacificus
KW  - Ixodidae
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Ixodes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - immunogens
KW  - Ixodes neotomae
KW  - Ixodes spinipalpis
KW  - lyme borreliosis
KW  - PCR
KW  - sodium dodecyl sulfate-PAGE
KW  - United States of America
KW  - Land Resources (PP300) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Ocular infections in the acquired immunodeficiency syndrome.
AU  - Dugel, P. U.
AU  - Rao, N. A.
JO  - International Ophthalmology Clinics
JF  - International Ophthalmology Clinics
Y1  - 1993///
VL  - 33
IS  - 1
SP  - 103
EP  - 127
SN  - 0020-8167
AD  - Dugel, P. U.: National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19942024237.  Publication Type: Journal Article.  Language: English.  Number of References: 99 ref. Subject Subsets: Public Health
N2  - The authors review posterior segment infections (of the retina, optic nerve and choroid mainly due to cytomegalovirus, Cryptococcus neoformans and Pneumocystis carinii) and anterior segment manifestations (including Kaposi's sarcoma, molluscum contagiosum, herpes zoster, keratitis and conjunctival conditions)D.W. FitzSimons
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Clinical aspects
KW  - Cryptococcosis
KW  - eye diseases
KW  - HIV infections
KW  - infections
KW  - Kaposi's sarcoma
KW  - mycoses
KW  - Neoplasms
KW  - Opportunistic infections
KW  - Pathology
KW  - pneumocystosis
KW  - Retinitis
KW  - viral diseases
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - AIDS
KW  - cancers
KW  - clinical picture
KW  - european blastomycosis
KW  - human immunodeficiency virus infections
KW  - Ophthalmology
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Synthesis of 11-[³H]-arteether, an experimental antimalarial drug.
AU  - Pu, Y. M.
AU  - Ziffer, H.
JO  - Journal of Labelled Compounds and Radiopharmaceuticals
JF  - Journal of Labelled Compounds and Radiopharmaceuticals
Y1  - 1993///
VL  - 33
IS  - 11
SP  - 1013
EP  - 1018
SN  - 0362-4803
AD  - Pu, Y. M.: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950801121.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 75887-54-6, 63968-64-9.  Subject Subsets: Botanical Pesticides; Protozoology
N2  - The triphenylphosphine hydrobromide-catalyzed addition of a proton from ethanol to anhydrodihydroartemisinin was employed for the synthesis of a β-arteether derivative and 11-epi-βarteether. Use of 1.5 equivalents of EtO²H or EtO³H yielded 11-[²H]- or 11-[³H]-β-arteether as the major product.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - arteether
KW  - ARTEMISININ
KW  - derivatives
KW  - human diseases
KW  - malaria
KW  - novel antiprotozoal agents
KW  - parasites
KW  - synthesis
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - artemisinine
KW  - qinghaosu
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Metabolic rate and body composition of Pima Indian and Caucasian children.
AU  - Fontvieille, A. M.
AU  - Ravussin, E.
JO  - CRC Critical Reviews in Food Science and Nutrition
JF  - CRC Critical Reviews in Food Science and Nutrition
Y1  - 1993///
VL  - 33
IS  - 4/5
SP  - 363
EP  - 368
SN  - 1040-8398
AD  - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19941411293.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - A low metabolic rate for a given body size and body composition may be a risk factor for body weight gain. Because the prevalence of obesity exceeds 75% in the Pima Indian population, body composition (bioelectrical resistance) and resting metabolic rate (RMR) of 43 Pima Indian children (9.9±1.1 years old) and 42 Caucasian children (9.7±1.2 years old) were investigated. Pima Indian children were taller (P&lt;0.001), heavier (P&lt;0.001) and fatter (P&lt;0.0001) than Caucasian children. Absolute values of RMR were higher in the Pimas than in the Caucasians (P&lt;0.001), but were similar when adjusted for differences in body size, body composition and sex. In Pima Indian girls before puberty (&lt;10 years old; n = 8), adjusted values of RMR were negatively correlated with the mean body mass index (BMI) of the parents (r = -0.88; P&lt;0.005). As resting metabolic rate was not low in Pima children, it is suggested that the major factors in the weight gain of 10-year-old Pima children may be reduced physical activity and/or excess energy intake. However, the possibility that a low metabolic rate may be a predisposing factor at an earlier age was not excluded.
KW  - body composition
KW  - children
KW  - ethnic groups
KW  - metabolism
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Workshop on child and adolescent obesity: what, how, and who
KW  - Physiology of Human Nutrition (VV120) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - NMR structure determination and intramolecular transesterification of four diacetyl taxinines which co-elute with taxol obtained from Taxus x. media Hicksii needles.
AU  - Chmurny, G. N.
AU  - Paukstelis, J. V.
AU  - Belinda Alvarado, A.
AU  - McGuire, M. T.
AU  - Snader, K. M.
AU  - Muschik, G. M.
AU  - Hilton, B. D.
JO  - Phytochemistry
JF  - Phytochemistry
Y1  - 1993///
VL  - 34
IS  - 2
SP  - 477
EP  - 483
SN  - 0031-9422
AD  - Chmurny, G. N.: Chemical Synthesis and Analysis Laboratory, Program Resources, Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19950603031.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 33069-62-4. 
N2  - Taxol (an antineoplastic agent) isolates from Taxus media include four taxinines which co-elute and interfere with HPLC analyses of taxol. Their structures (1,9α-dihydroxy-2α,10β-diacetoxy-5α-cinnamatetaxa-4(20),11-diene-13-one; 1,10β-dihydroxy-2α,9α-diacetoxy-5α-cinnamatetaxa-4(20),11-diene-13-one; 2α,9α-dihydroxy-10β-13α-diacetoxy-5α-cinnamatetaxa-4(20),11-diene and; 2α,10β-dihydroxy-9α,13α-diacetoxy-5α-cinnamatetaxa-4(20),11-diene) have been determined by 1D(1H, 13C) and 2D(DQCOSY, TOCSY, HMQC, HMBC and TROESY) NMR spectroscopy. Transacetylation between 10β and 9α on the baccatin core has been documented to occur in CDCl3 and CD3OD at 27°. Interatomic distances were obtained from TROESY build-up curves of the first compound and were compared to those obtained from a computer minimized structure.
KW  - antineoplastic agents
KW  - chemical composition
KW  - chemical structure
KW  - diterpenoids
KW  - foliage
KW  - forest trees
KW  - leaves
KW  - medicinal plants
KW  - paclitaxel
KW  - plant composition
KW  - trees
KW  - woody plants
KW  - plants
KW  - Taxaceae
KW  - Taxus media
KW  - eukaryotes
KW  - Taxopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - Taxus
KW  - Taxaceae
KW  - chemical constituents of plants
KW  - cytotoxic agents
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - taxinines
KW  - taxol
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.
AU  - Ikewaki, K.
AU  - Rader, D. J.
AU  - Schaefer, J. R.
AU  - Fairwell, T.
AU  - Zech, L. A.
AU  - Brewer, H. B., Jr.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1993///
VL  - 34
IS  - 12
SP  - 2207
EP  - 2215
SN  - 0022-2275
AD  - Ikewaki, K.: Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941412204.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Human Nutrition
KW  - apolipoproteins
KW  - lipid metabolism
KW  - metabolism
KW  - methodology
KW  - tracer techniques
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fat metabolism
KW  - methods
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Coumermycin A1 inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent.
AU  - Scott Samuels, D.
AU  - Garon, C. F.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1993///
VL  - 37
IS  - 1
SP  - 46
EP  - 50
SN  - 0066-4804
AD  - Scott Samuels, D.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950802817.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 4434-05-3, 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Coumermycin A1 is an inhibitor of DNA gyrase, an enzyme that catalyses supercoiling of DNA and is required for bacterial DNA replication. B. burgdorferi was shown to be more susceptible than many other eubacteria to coumermycin; this contrasted with its relative resistance to the DNA gyrase inhibitors nalidixic acid, oxolinic acid, and ciprofloxacin. Coumermycin at 0.2 μg/ml inhibited the growth of B. burgdorferi B31 in BSK II medium. A 100-fold-lower concentration induced the relaxation of 2 negatively supercoiled circular plasmids within 2 hours. Plasmid supercoiling was restored within 2 h of removal of coumermycin. These results suggest that B. burgdorferi has a DNA gyrase and that this enzyme's activity is required for growth. Structural analogues of coumermycin might be considered for use in the treatment of Lyme borreliosis.
KW  - antibiotics
KW  - coumamycin
KW  - DNA
KW  - DNA replication
KW  - drug therapy
KW  - human diseases
KW  - Lyme disease
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - chemotherapy
KW  - coumerins
KW  - coumermycin
KW  - deoxyribonucleic acid
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection.
AU  - Kovacs, J. A.
AU  - Powell, F.
AU  - Voeller, D.
AU  - Allegra, C. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1993///
VL  - 37
IS  - 6
SP  - 1227
EP  - 1231
SN  - 0066-4804
AD  - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19940803533.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 36703-88-5.  Subject Subsets: Protozoology; Medical & Veterinary Mycology
N2  - Isoprinosine has been reported to decrease the progression of AIDS in HIV-infected patients, primarily by preventing Pneumocystis carinii pneumonia (PCP), but the mechanism of action is unknown. Para-Acetamidobenzoic acid (PAcBA) is a component of isoprinosine structurally related to para-aminobenzoic acid (PABA), a precursor of de novo folate synthesis. This pathway is known to be important for P. carinii because sulfonamides, which are effective anti-P. carinii agents, inhibit incorporation of PABA into folate precursors by the enzyme dihydropteroate synthetase (DHPS). Inhibition of P. carinii DHPS by PAcBA was investigated by using two assays. In short term cultures of P. carinii from rats, [³H]PABA incorporation into reduced folates was inhibited by both isoprinosine and PAcBA free acid. However, it was found that a soluble PAcBA salt was more potent than PAcBA free acid alone. In a rat model of PCP, the PAcBA salt administered intraperitoneally demonstrated no activity against established PCP either alone or when in combination with trimethoprim. Prevention of PCP by PAcBA through inhibition of P. carinii DHPS may explain the activity of isoprinosine in decreasing the progression of AIDS.
KW  - acquired immune deficiency syndrome
KW  - aminobenzoic acids
KW  - antifungal agents
KW  - antifungal properties
KW  - antiprotozoal agents
KW  - folate antagonists
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - Immunomodulators
KW  - infections
KW  - inosine pranobex
KW  - laboratory animals
KW  - lungs
KW  - mode of action
KW  - opportunistic infections
KW  - parasites
KW  - pneumonia
KW  - respiratory diseases
KW  - sulfonamides
KW  - treatment
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - rats
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - Muridae
KW  - rodents
KW  - AIDS
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - lung diseases
KW  - para-acetamidobenzoic acid
KW  - sulphonamides
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development and characterization of a rapid screening assay for identifying antipneumocystis agents.
AU  - Martínez, A.
AU  - Kovacs, J. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1993///
VL  - 37
IS  - 8
SP  - 1674
EP  - 1678
SN  - 0066-4804
AD  - Martínez, A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200170.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 1397-89-3, 95233-18-4, 100-33-4, 140-64-7, 723-46-6, 738-70-5.  Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - A rapid assay was developed for the screening of compounds with potential anti-Pneumocystis activity on the basis of incorporation of [35S]methionine into proteins newly synthesized by P. carinii. Unambiguous evidence that P. carinii synthesizes proteins in vitro was provided by immunoprecipitation studies demonstrating the incorporation of [35S]methionine into the major surface glycoprotein. Treatment with 2 clinically active anti-Pneumocystis agents, atovaquone (10-4M) or pentamidine (10-4M), prevented this incorporation. Total [35S]methionine incorporation paralleled incorporation into the major surface glycoprotein, permitting rapid assessment of anti-P.carinii activity by scintillation counting. Treatment with pentamidine (1 × 10-4M), atovaquone, trimethoprim (1 × 10-4M)-sulfamethoxazole (7.9 × 10-4M), piritrexim (1 × 10-7M), RO11-8958 [epiroprim] (1 × 10-4M) and amphotericin B (1 µg/ml) resulted in a greater than 67% inhibition (P&lt;0.05) of [35S]methionine incorporation. No decrease in [35S]methionine incorporation was seen with dapsone (10-5M), trimethoprim (10-4M), recombinant mouse tumor necrosis factor (500 ng/ml) or gamma interferon. It is concluded that this rapid in vitro assay should be a useful adjunct in the development of new anti-Pneumocystis agents.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - atovaquone
KW  - drugs
KW  - parasites
KW  - pentamidine
KW  - sulfamethoxazole
KW  - techniques
KW  - testing
KW  - trimethoprim
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - anti-fungal properties
KW  - epiroprim
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - medicines
KW  - pharmaceuticals
KW  - piritrexim
KW  - Ro 11-8958
KW  - sulphamethoxazole
KW  - susceptibility testing
KW  - trimethoprim sulfamethoxazole
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The challenge of Pneumocystis carinii culture.
AU  - Sloand, E.
AU  - Laughon, B.
AU  - Armstrong, M.
AU  - Bartlett, M. S.
AU  - Blumenfeld, W.
AU  - Cushion, M.
AU  - Kalica, A.
AU  - Kovacs, J. A.
AU  - Martin, W.
AU  - Pitt, E.
AU  - Pesanti, E. L.
AU  - Richards, F.
AU  - Rose, R.
AU  - Walzer, P.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1993///
VL  - 40
IS  - 2
SP  - 188
EP  - 195
SN  - 1066-5234
AD  - Sloand, E.: National Heart, Lung and Blood Institute, Building 31, Room 5A48, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804891.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Protozoology; Medical & Veterinary Mycology
N2  - Published and unpublished data on the cultivation of P. carinii, both in cell-free systems and with feeder cells, were reviewed by a panel of investigators convened by the National Institutes of Health. Although several cell culture systems allow propagation of P. carinii for a limited time with modest rates of replication, these have not proved adequate for isolation of P. carinii in sufficient quantity to explore important basic biological investigation. Attempts at cell-free culture have yielded only transient proliferation. The unsuccessful work on cultivation of the organism has been unpublished, although the panel agreed that these data may be useful to other investigators in designing experimental strategies for cultivation. The purpose of this report is therefore to make available this information to researchers and prevent repetition of unsuccessful methods. It is hoped that by documenting the history and the complexities of Pneumocystis culture, renewed interest and efforts will be directed toward this scientific challenge.
KW  - culture techniques
KW  - Human diseases
KW  - Opportunistic infections
KW  - parasites
KW  - reviews
KW  - techniques
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nine-year follow-up study of a plasma-derived hepatitis B vaccine in a rural African setting.
AU  - Tabor, E.
AU  - Cairns, J.
AU  - Gerety, R. J.
AU  - Bayley, A. C.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1993///
VL  - 40
IS  - 3
SP  - 204
EP  - 209
SN  - 0146-6615
AD  - Tabor, E.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050584.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - One hundred and one of 255 recipients of a plasma-derived hepatitis B vaccine were evaluated in 1990, 9 years after the first vaccine dose in a study in Zambia to evaluate the efficacy of one, two or three doses. In 1983, 2 years after the first vaccine dose, antibody to the hepatitis B surface antigen (anti-HBs) had been detectable in 90 of these 101 participants (89%). In 1990, anti-HBs was still detectable in 72 of 101 (71%), and was present at a protective level (≥10 mIU/ml) in 68 of 101 (87%). Although the original vaccine study elicited a protective level of antibody in a greater percentage of children and adolescents than in adults, there were no significant differences among the three groups at 9 years. (In 1990, anti-HBs was still detectable in 52 of 70 (74%) who had had no serologic markers of the hepatitis B virus in 1981, and a protective level was detected in 47 of 70 (67%)). A protective level of anti-HBs was detected in 1990 in 26 of 36 (72% recipients of three doses and in 23 of 31 (74%) recipients of two doses; the slightly lower prevalence among recipients of one dose (19 of 34 (56%)) was not statistically significant. However, between the years 1983-1990, hepatitis B virus infections had occurred in one of 36 (3%) of those who had been vaccinated with three doses, one of 31 (3%) vaccinated with two doses, and eight of 34 (24%) of those vaccinated with one dose (P &lt;0.02) for either two or three doses compared with one dose). These data support the long-term immunogenicity and protective efficacy of a two- or three-dose regimen of the hepatitis B vaccine in a rural African setting.
KW  - hepatitis B
KW  - immunization
KW  - vaccines
KW  - Africa
KW  - Zambia
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - Southern Africa
KW  - Africa South of Sahara
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - A redescription of Entamoeba histolytica Schaudinn, 1903 (Emended Walker, 1911) separating it from Entamoeba dispar Brumpt, 1925.
AU  - Diamond, L. S.
AU  - Clark, C. G.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1993///
VL  - 40
IS  - 3
SP  - 340
EP  - 344
SN  - 1066-5234
AD  - Diamond, L. S.: Laboratory of Parasitic Diseases, Building 4/Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806852.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Subject Subsets: Protozoology
N2  - The existence of 2 morphologically identical species of Entamoeba histolytica was first proposed by Brumpt in 1925. This study reexamines Brumpt's claim in the light of recent biochemical, immunological and genetic studies and it is concluded that the data derived from these investigations provide unequivocal evidence supporting his hypothesis. Consequently, the invasive parasite is redescribed, retaining the name Entamoeba histolytica, and is set apart from the noninvasive parasite, Entamoeba dispar.
KW  - chemotaxonomy
KW  - DNA probes
KW  - Human diseases
KW  - Monoclonal antibodies
KW  - Morphology
KW  - parasites
KW  - Pathogenicity
KW  - Polymerase chain reaction
KW  - redescriptions
KW  - Taxonomy
KW  - Zymodemes
KW  - Entamoeba dispar
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical taxonomy
KW  - Entamoebidae
KW  - PCR
KW  - systematics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hydrolase compartmentalization limits rate of digestion in Acanthamoeba.
AU  - Hohman, T. C.
AU  - Bowers, B.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1993///
VL  - 40
IS  - 5
SP  - 589
EP  - 593
SN  - 1066-5234
AD  - Hohman, T. C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Room B1-22, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803197.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology
N2  - The kinetics of lysosomal enzyme acquisition by newly formed phagosomes was studied by following the rate of digestion of radiolabelled yeast fed to Acanthamoeba castellanii. The distribution of hydrolases among phagosomes was assessed by electron microscopic acid phosphatase cytochemistry and by measurement of 3 glycosidases in isolated early and late phagosomes. The results show that compartmentalization of hydrolases limit the digestion of large phagocytic loads. The hydrolases appear to be sequestered into the early phagosomes and not to be distributed either by small vesicle transport or phagosome-phagosome fusion to those formed later. From these results it is inferred that newly internalized surface membrane in phagosomes is not rapidly randomized with internal pools, but is recycled to the surface as a function of the digestive process.
KW  - biochemistry
KW  - digestion
KW  - enzymes
KW  - hydrolases
KW  - parasites
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Norepinephrine turnover and energy expenditure in Pima Indian and white men.
AU  - Christin, L.
AU  - O'Connell, M.
AU  - Bogardus, C.
AU  - Danforth, E., Jr.
AU  - Ravussin, E.
JO  - Metabolism, Clinical and Experimental
JF  - Metabolism, Clinical and Experimental
Y1  - 1993///
VL  - 42
IS  - 6
SP  - 723
EP  - 729
SN  - 0026-0495
AD  - Christin, L.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th St, Room 541, Phoenix AZ 85016, USA.
N1  - Accession Number: 19941409148.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 51-40-1, 51-41-2, 69815-49-2.  Subject Subsets: Human Nutrition
N2  - There is growing evidence of the involvement of sympathetic nervous system (SNS) activity in determining metabolic rate. Whole-body plasma norepinephrine turnover and its relation to resting metabolic rate (RMR) and 24-h energy expenditure (24EE) were compared in 14 Pima Indian men (25±4 years old, 96±33 kg, 25±9% fat) and 9 white men (25±3 years old, 88±43 kg, 17±13% fat). Plasma norepinephrine turnover rate correlated strongly with body surface area (r = 0.76 and 0.54 for clearance and appearance, respectively) and fat-free mass (r = 0.74 and 0.52, respectively). However, independent of body size, there was no difference in norepinephrine clearance or appearance rates between Pima Indian and white men. Norepinephrine appearance rate correlated positively with absolute values of 24EE and RMR, but not when adjusted for differences in body surface area or fat-free mass. However, norepinephrine appearance rate adjusted for differences in body size correlated with spontaneous physical activity. Results indicate that Pima Indian and white men have similar plasma norepinephrine appearance rates, but Pima Indians tend to be more resistant to β-adrenergic stimulation. Although energy expenditure and SNS activity were not directly related, a higher SNS tone may promote or reflect elevated levels of spontaneous physical activity and therefore influence energy balance and body composition.
KW  - body composition
KW  - energy exchange
KW  - ethnic groups
KW  - men
KW  - norepinephrine
KW  - obesity
KW  - physical activity
KW  - sympathetic nervous system
KW  - turnover
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - noradrenaline
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A standard procedure for measuring pellet hardness of rodent diets.
AU  - Thigpen, J. E.
AU  - Locklear, J.
AU  - Romines, C.
AU  - Taylor, K. A.
AU  - Yearby, W.
AU  - Stokes, W. S.
JO  - Laboratory Animal Science
JF  - Laboratory Animal Science
Y1  - 1993///
VL  - 43
IS  - 5
SP  - 488
EP  - 491
SN  - 0023-6764
AD  - Thigpen, J. E.: Comparative Medicine Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19951407368.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Animal Nutrition; Human Nutrition
N2  - A Chatillon Model TCM-200 test stand with exchangeable flat horizontal or concave receptacle bases and a DFI-200 gauge load cell with multiple types of upper exchangeable test jaws (large round-flat, medium round-flat, chisel, bullet, and cone-shaped) were compared by using preautoclaved and autoclaved NIH-31 rodent diet pellets to determine which type of hardness testing system would give the most accurate and reproducible results for measuring pellet hardness. The type and size of the contact area of the upper jaws significantly affected the force required to break the pellets. Significant differences were observed between the flat-horizontal and concave receptacle bases in the force required to break the pellets when using the two round-flat upper jaws. In contrast, similar results were obtained with both bases when the bullet, chisel, or cone-shaped upper jaws were used. Autoclaved pellets were 69.4% (range, 49 to 94%) harder than preautoclaved pellets. These results suggest that different testing systems can be used for measuring pellet hardness and that a standard procedure must be used in order to compare pellet hardness results between different testing laboratories. It was concluded that the flat-horizontal base and the larger round-flat end upper jaw gave the most reproducible results for measuring pellet hardness.
KW  - analytical methods
KW  - diet
KW  - hardness
KW  - pellets
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - Techniques and Methodology (ZZ900) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diagnostic exercise: gastritis in athymic nude mice [Candida albicans].
AU  - Dixon, D.
AU  - Goelz, M. F.
AU  - Locklear, J.
AU  - Myers, P. H.
AU  - Thigpen, J. E.
JO  - Laboratory Animal Science
JF  - Laboratory Animal Science
Y1  - 1993///
VL  - 43
IS  - 5
SP  - 497
EP  - 499
SN  - 0023-6764
AD  - Dixon, D.: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19932294218.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Animal Nutrition; Veterinary Science; Medical & Veterinary Mycology
N2  - An outbreak of gastritis is reported in laboratory mice, which were found moribund or dead during a period of 10 months. Four of 15 male, athymic, nude mice were found dead and were diagnosed with bacterial septicaemia based on light microscopic or microbiological examination. Post-mortem examination revealed a thickened forestomach and pseudomembrane formation on the mucosal surface. Gross lesions associated with the changes in the forestomach were not found in other organs. Within the layers of the forestomach mucosa were numerous septated filamentous structures and budding ovoid organisms that stained positively with periodic acid-Schiff and Grocott methenamine silver stain. Candida albicans was cultured from forestomach scrapings.
KW  - case reports
KW  - digestive tract
KW  - gastritis
KW  - hosts
KW  - infections
KW  - laboratory animals
KW  - mycoses
KW  - pathology
KW  - stomach diseases
KW  - USA
KW  - Candida
KW  - Candida albicans
KW  - mice
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fungus
KW  - gastrointestinal tract
KW  - Hyphomycetes
KW  - United States of America
KW  - Laboratory Animal Science (LL040) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased immunogenicity and protective efficacy in outbred and inbred mice by strategic carboxyl-terminal truncation of Japanese encephalitis virus envelope glycoprotein.
AU  - Jan LeiRon
AU  - Yang CzauSiung
AU  - Henchal, L. S.
AU  - Sumiyoshi, H.
AU  - Summers, P. L.
AU  - Dubois, D. R.
AU  - Lai ChingJuh
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1993///
VL  - 48
IS  - 3
SP  - 412
EP  - 423
SN  - 0002-9637
AD  - Jan LeiRon: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930516339.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - Recombinant vaccinia viruses expressing the full-length envelope (E) glycoprotein of Japanese encephalitis virus (JEV) or a strategically truncated E glycoprotein, approximately 80% of the N-terminal sequence, were constructed and their antigenic structure and protective immunity in mice compared. The truncation site in the JEV E glycoprotein sequence corresponds to the position that had been shown to increase the immunogenicity of dengue type 4 or type 2 virus E glycoprotein. Analysis of the JEV E glycoprotein in recombinant virus-infected cells showed that C-terminally truncated E retains an antigenic structure similar to that of the full-length E glycoprotein. The full-length JEV E glycoprotein was detected predominantly intracellularly, while a small fraction (&lt;2%) was present on the cell structure. On the other hand, the truncated 80% E glycoprotein exhibited an alteration in the intracellular transport pathway resulting in increased accumulation (10-25%) on the cell surface and secretion (6-10%) into the medium. The C-terminally truncated E glycoprotein induced a greater antibody response and a higher level of protective immunity than did the full-length E glycoprotein in outbred CD-1 mice as well as in 2 strains of inbred mice that differ in their resistance to intraperitoneal (ip) JEV infection. In the case of outbred CD-1 and inbred C57/B1 mice, which possess a dominant autosomal genetic locus that controls resistance to a high dose of ip infection of JEV or the capacity to acquire resistance to intracerebral JEV infection, truncated E glycoprotein induced a higher titre of JEV neutralizing antibodies.
KW  - Arboviruses
KW  - Glycoproteins
KW  - immunization
KW  - Laboratory animals
KW  - Vaccines
KW  - Viral diseases
KW  - Viral proteins
KW  - Flavivirus
KW  - Japanese encephalitis virus
KW  - mice
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Flavivirus
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - immune sensitization
KW  - immunogenicity
KW  - viral infections
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biology and pathology of Schistosoma mansoni and Schistosoma japonicum infections in several strains of nude mice.
AU  - Cheever, A. W.
AU  - Eltoum, I. S.
AU  - Andrade, Z. A.
AU  - Cox, T. M.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1993///
VL  - 48
IS  - 4
SP  - 496
EP  - 503
SN  - 0002-9637
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930806467.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Tropical Diseases; Helminthology
N2  - Schistosoma mansoni and S. japonicum infections in nude mice (nu/nu) were compared with infections in nu/+ heterozygotes or intact mice. Seven to 12 weeks after the exposure to S. mansoni, the responses of Swiss NCR, C3H, BALB/c and C57BL/6 nude mice did not differ substantially. Nude mice of all these strains showed minute granulomata around ova in the liver and minimal hepatic fibrosis. Microvesicular and necrotizing changes in hepatocytes were similar in all mouse strains, and S. mansoni infections were frequently lethal to nude, but not to intact mice between the 7th and 9th weeks of infection. Nude mice that survived the 9th week of infection generally lived until the 12th week. The number of ova/mature worm pair in the tissues of S. mansoni-infected nude mice was similar to the number in intact mice, but nude mice passed fewer ova in the faeces. Nude mice that received serum from infected intact mice excreted ova in the stool in numbers equivalent to intact mice, but continued to form minute granulomata around S. mansoni ova. Reconstitution with fetal thymus or with splenocytes from normal or S. mansoni-infected mice partially or completely restored hepatic granuloma size, granuloma eosinophils, hepatic fibrosis, and excretion of ova in the faeces. In contrast to S. mansoni infection, S. japonicum infections in nude mice did not cause necrosis of hepatocytes or excessive mortality, and S. japonicum ova were passed in the faeces in numbers equivalent to those passed by infected intact mice.\From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Schistosoma mansoni and S. japonicum infections in nude mice (nu/nu) were compared with infections in nu/+ heterozygotes or intact mice. Seven to 12 weeks after the exposure to S. mansoni, the responses of Swiss NCR, C3H, BALB/c and C57B1/6 nude mice did not differ substantially. Nude mice of all these strains showed minute granulomata around ova in the liver and minimal hepatic fibrosis. Microvesicular and necrotizing changes in hepatocytes were similar in all mouse strains, and S. mansoni infections were frequently lethal to nude, but not to intact mice between the 7th and 9th weeks of infection. Nude mice that survived the 9th week of infection generally lived until the 12th week. The number of ova/mature worm pair in the tissues of S. mansoni-infected nude mice was similar to the number in intact mice, but nude mice passed fewer ova in the faeces. Nude mice that received serum from infected intact mice excreted ova in the stool in numbers equivalent to intact mice, but continued to form minute granulomata around S. mansoni ova. Reconstitution with fetal thymus or with splenocytes from normal or S. mansoni-infected mice partially or completely restored hepatic granuloma size, granuloma eosinophils, hepatic fibrosis, and excretion of ova in the faeces. In contrast to S. mansoni infection, S. japonicum infections in nude mice did not cause necrosis of hepatocytes or excessive mortality, and S. japonicum ova were passed in the faeces in numbers equivalent to those passed by infected intact mice.
KW  - Experimental infections
KW  - helminths
KW  - Human diseases
KW  - immunocompromised hosts
KW  - Laboratory animals
KW  - parasites
KW  - pathogenesis
KW  - pathology
KW  - schistosomiasis
KW  - strain differences
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Rodents
KW  - Schistosoma japonicum
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - Granulomas
KW  - nude mice
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of agricultural pesticide use in the development of non-Hodgkin's lymphoma in women.
AU  - Zahm, S. H.
AU  - Weisenburger, D. D.
AU  - Saal, R. C.
AU  - Vaught, J. B.
AU  - Babbitt, P. A.
AU  - Blair, A.
JO  - Archives of Environmental Health
JF  - Archives of Environmental Health
Y1  - 1993///
VL  - 48
IS  - 5
SP  - 353
EP  - 358
SN  - 0003-9896
AD  - Zahm, S. H.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Rockville, MD 20892, USA.
N1  - Accession Number: 19942027294.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Public Health
N2  - Non-Hodgkin's lymphoma has been found to be associated with agricultural pesticide use in men, but little is known about the risk in women. In a recent population-based, case-control study conducted in eastern Nebraska [USA], no increased risk of non-Hodgkin's lymphoma was found in women who had ever lived or worked on a farm (odds ratio [OR] = 1.0). Neither the use of insecticides (OR = 0.8) nor herbicides (OR = 0.7) on the farm was associated with non-Hodgkin's lymphoma; however, the number of women who mixed or applied pesticides was small, particularly in comparison to men on farms. Small non-significant associations were observed among the women who personally handled insecticides (OR = 1.3) or herbicides (OR = 1.2). Women who personally handled organophosphate insecticides had a significant 4.5-fold increased risk of non-Hodgkin's lymphoma. Use of chlorinated hydrocarbon insecticides was associated with an OR of 1.6; however, the use on dairy cattle was associated with a 3-fold increased risk. Pesticide-related risks were greater among women with a family history of cancer, particularly a history of lymphatic or haematopoietic cancer among first-degree relatives. AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Non-Hodgkin's lymphoma has been found to be associated with agricultural pesticide use in men, but little is known about the risk in women. In a recent population-based, case-control study conducted in eastern Nebraska, USA, no increased risk of non-Hodgkin's lymphoma was found in women who had ever lived or worked on a farm (odds ratio [OR] = 1.0). Neither the use of insecticides (OR = 0.8) nor herbicides (OR = 0.7) on the farm was associated with non-Hodgkin's lymphoma; however, the number of women who mixed or applied pesticides was small, particularly in comparison to men on farms. Small nonsignificant associations were observed among the women who personally handled insecticides (OR - 1.3) or herbicides (OR = 1.2). Women who personally handled organophosphate insecticides had a significant 4.5-fold increased risk of non-Hodgkin's lymphoma. Use of chlorinated hydrocarbon insecticides was associated with an OR of 1.6; however, the use on dairy cattle was associated with a 3-fold increased risk. Pesticide-related risks were greater among women with a family history of cancer, particularly a history of lymphatic or haematopoietic cancer among first-degree relatives.
KW  - dairy cattle
KW  - epidemiology
KW  - farm workers
KW  - herbicides
KW  - insecticides
KW  - lymphoma
KW  - non-Hodgkin's lymphoma
KW  - occupational hazards
KW  - organochlorine insecticides
KW  - organophosphorus insecticides
KW  - pesticides
KW  - risk factors
KW  - Toxicology
KW  - women
KW  - Nebraska
KW  - North America
KW  - USA
KW  - cattle
KW  - man
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Northern Plains States of USA
KW  - West North Central States of USA
KW  - North Central States of USA
KW  - United States of America
KW  - weedicides
KW  - weedkillers
KW  - Occupational Health and Safety (VV900) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Women (UU500) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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ER  - 

TY  - JOUR
T1  - Acute leukemia and residential proximity to potential sources of environmental pollutants.
AU  - Shore, D. L.
AU  - Sandler, D. P.
AU  - Davey, F. R.
AU  - McIntyre, O. R.
AU  - Bloomfield, C. D.
JO  - Archives of Environmental Health
JF  - Archives of Environmental Health
Y1  - 1993///
VL  - 48
IS  - 6
SP  - 414
EP  - 420
SN  - 0003-9896
AD  - Shore, D. L.: (D. Sandler) National Institute of Environmental Health Sciences, Mail Drop A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19942027286.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Possible associations between location of residence and acute leukaemia risk were investigated in a study of 610 newly diagnosed patients [from Canada and the USA], aged 18-79 years, and 618 population controls. There was an association between ever living within 5 miles (8 km) of an industrial plant and leukaemia risk, with adjusted odds ratios (ORs) of 1.4 (95% confidence interval [95% CI] = 1.0-1.9) for all acute leukaemias combined, 1.4 (95% CI = 1.0-2.0) for acute myeloid leukaemia, and 1.7 (95% CI = 1.0-2.7) for acute lymphocytic leukaemia. Odds ratios increased with decreasing distance from industrial sites, but a gradient with duration of residence was seen only among those less than age 60 who had lived within a mile of any industry. Suggestive associations were also observed for residence near specific industries, but the number of individuals living near any one industry was small.AS
KW  - industrial sites
KW  - Leukaemia
KW  - risk factors
KW  - Canada
KW  - North America
KW  - USA
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood cancer
KW  - leucaemia
KW  - leukemia
KW  - United States of America
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Regression of hepatic lesions after treatment of Schistosoma mansoni or Schistosoma japonicum infection in mice: a comparative study.
AU  - Andrade, Z. A.
AU  - Cox, T. M.
AU  - Cheever, A. M.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1993///
VL  - 49
IS  - 1
SP  - 1
EP  - 9
SN  - 0002-9637
AD  - Andrade, Z. A.: (A.W. Cheever) Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940800238.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 55268-74-1.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Experimental infections with Schistosoma mansoni and S. japonicum differ in several aspects and post-treatment resorption of fibrosis might be one of them. To investigate this point, mice infected with each of these schistosome species were treated with praziquantel and the evolution of hepatic lesions was sequentially followed for 5 months. Parasitologic data showing destruction of worms and eggs and biochemical findings of progressively decreased collagen concentration after cure indicated that the lesions caused by S. mansoni and S. japonicum involuted in a similar fashion following chemotherapy. The time sequence of the histologic changes indicative of decreasing inflammation and progressive matrix degradation and resorption was also similar in both cases.AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Experimental infections with Schistosoma mansoni and S. japonicum differ in several aspects and post-treatment resorption of fibrosis might be one of them. To investigate this point, mice infected with each of these schistosome species were treated with praziquantel and the evolution of hepatic lesions was sequentially followed for 5 months. Parasitologic data showing destruction of worms and eggs and biochemical findings of progressively decreased collagen concentration after cure indicated that the lesions caused by S. mansoni and S. japonicum involuted in a similar fashion following chemotherapy. The time sequence of the histologic changes indicative of decreasing inflammation and progressive matrix degradation and resorption was also similar in both cases.
KW  - anthelmintics
KW  - disease models
KW  - drug therapy
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - laboratory animals
KW  - Lesions
KW  - Liver
KW  - parasites
KW  - pathology
KW  - praziquantel
KW  - schistosomiasis
KW  - Treatment
KW  - Digenea
KW  - Mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma japonicum
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - chemotherapy
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human retroviruses in Amerindians of Colombia: high prevalence of human T cell lymphotropic virus type II infection among the Tunebo Indians.
AU  - Duenas-Barajas, E.
AU  - Bernal, J. E.
AU  - et al.
AU  - Vaught, D. R. (
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1993///
VL  - 49
IS  - 6
SP  - 657
EP  - 663
SN  - 0002-9637
AD  - Duenas-Barajas, E.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028007.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - The coexistence of infection with human T lymphotropic virus types I and II (HTLV-I and HTLV-II) has been demonstrated recently among the Wayuu Indians from the Guajira region of Colombia. To ascertain if other Indian groups in Colombia are similarly infected, [the authors] tested 1250 sera, collected between 1990 and 1992 from 18 culturally distinct Amerindian tribes living in widely separated regions, for IgG antibodies against HTLV-I/II using enzyme-linked immunosorbent assay (ELISA) and Western blot. Sera were also tested for antibodies against human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) to investigate the overall burden of retrovirus infection in these semi-isolated indigenous groups. A total of 33 of the 1250 samples were repeatedly reactive to HTLV-I/II antigens by ELISA, and of these, three sera from Waunana/Noanama Indians from the Choco area and two sera from Tunebo Indians from the Santander region were found to be infected with HTLV-I and HTLV-II, respectively, as verified by Western blot and differential ELISA. Thus, despite the small sample size, the overall seroprevalences for HTLV-I and HTLV-II infection among the Waunana/Noanama and Tunebo Indians were 2.1% and 5.0%, respectively. In contrast, none of the 29 Indians who exhibited reactivity to HIV-1/2 by ELISA were seropositive by Western blot. This study adds the Tunebo to the expanding list of Amerindian groups with high prevalences of HTLV-II infection. Further intensive investigations of such indigenous populations will clarify the natural history and disease potential of HTLV-II infection. AS
KW  - American Indians
KW  - Colombia
KW  - South America
KW  - Deltaretrovirus
KW  - Human T-cell lymphotropic virus type II
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - HTLV-BLV group
KW  - prevalence
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neurological manifestations of malaria.
AU  - Roman, G. C.
AU  - Senanayake, N.
JO  - Arquivos de Neuro-Psiquiatria
JF  - Arquivos de Neuro-Psiquiatria
Y1  - 1993///
VL  - 50
IS  - 1
SP  - 3
EP  - 9
SN  - 0004-282X
AD  - Roman, G. C.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, (NINDS), National Institutes of Health, (NIH), Bethesda, MD 20892, USA.
N1  - Accession Number: 19940800507.  Publication Type: Journal Article.  Language: English.  Language of Summary: Portuguese.  Number of References: 42 ref. Subject Subsets: Protozoology
N2  - Neurological manifestations of malaria are reviewed under the headings: cerebral malaria; other cerebral manifestations; hypoglycaemia; delayed cerebellar ataxia; epilepsy; febrile seizures; spinal cord disorders; peripheral neuropathy; periodic paralysis.
KW  - Cerebral malaria
KW  - Human diseases
KW  - Malaria
KW  - Nervous system
KW  - parasites
KW  - pathology
KW  - reviews
KW  - Apicomplexa
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - neurological manifestations
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Non-Hodgkin's lymphoma and occupation in Sweden: a registry based analysis.
AU  - Linet, M. S.
AU  - Malker, H. S. R.
AU  - et al.
AU  - McLaughlin, J. K. (
JO  - British Journal of Industrial Medicine
JF  - British Journal of Industrial Medicine
Y1  - 1993///
VL  - 50
IS  - 1
SP  - 79
EP  - 84
SN  - 0007-1072
AD  - Linet, M. S.: National Cancer Institute, EPN 415B, Rockville, Maryland 20892, USA.
N1  - Accession Number: 19942025739.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Incidence of non-Hodgkin's lymphoma in different employment categories was evaluated from the Swedish Cancer-Environment Registry, which links cancer incidence during 1961 to 1979 with occupational information from the 1960 census. New associations were found for men employed in shoemaking and shoe repair, porcelain and earthenware industries, education, and other white collar occupations. Several findings supported associations found in other countries, including excesses among woodworkers, furniture makers, electric power plant workers, farmers, dairy workers, lorry drivers, and other land transport workers. Risks were not increased among chemists, chemical or rubber manufacturing workers, or petrochemical refinery workers. Caution must be used in drawing causal inferences from these linked registry data because information on exposure and duration of employment is not available. Nevertheless, this study has suggested new clues to possible occupational determinants of non-Hodgkin's lymphoma. AS
KW  - Non-Hodgkin's lymphoma
KW  - Occupational health
KW  - occupations
KW  - risk factors
KW  - Europe
KW  - Sweden
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum micronutrients and the subsequent risk of oral and pharyngeal cancer.
AU  - Zheng, W.
AU  - Blot, W. J.
AU  - Diamond, E. L.
AU  - Norkus, E. P.
AU  - Spate, V.
AU  - Morris, J. S.
AU  - Comstock, G. W.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1993///
VL  - 53
IS  - 4
SP  - 795
EP  - 798
SN  - 0008-5472
AD  - Zheng, W.: Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941403776.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
N2  - To investigate the relation between serum micronutrients and subsequent risk of oral and pharyngeal cancer, blood samples of 25 802 adults living in Washington County, USA, were collected in 1974 and stored at -70°C for subsequent assays. Serum values of nutrients in 28 subjects who developed oral and pharyngeal cancer during 1975 to 1990 were compared with values in 112 matched controls. Serum values of carotenoids, particularly β-carotene, were lower among subjects who developed oral and pharyngeal cancer. Risk of this malignancy decreased substantially with increasing serum value of each individual carotenoid. Persons in the highest tertile of total carotenoids had about one-third the cancer risk as those in the lowest tertile. High serum α-tocopherol was related to low oral cancer risk in later years, but risks were elevated significantly with increasing serum γ-tocopherol and selenium.
KW  - blood
KW  - carcinoma
KW  - carotenoids
KW  - mouth
KW  - pharynx
KW  - selenium
KW  - tocopherols
KW  - trace elements
KW  - vitamins
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - microelements
KW  - tetraterpenoids
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Correspondence re: K.P.Cantor et. al., Pesticides and other agricultural risk factors for non-Hodgkins lymphoma among men in Iowa and Minnesota, Cancer Res., 52: 2447-2455,1992.
AU  - Cantor, K. P.
AU  - Blair, A.
AU  - Brown, L. M.
AU  - Burmeister, L. F.
AU  - Everett, G.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1993///
VL  - 53
IS  - 10
SP  - 2421
EP  - 2421
SN  - 0008-5472
AD  - Cantor, K. P.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20982, USA.
N1  - Accession Number: 19951111299.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref.
N2  - This letter reports on additional findings not included in their original manuscript, as titled above.
KW  - Hodgkin's disease
KW  - insecticides
KW  - lymphoma
KW  - neoplasms
KW  - pesticides
KW  - Iowa
KW  - Minnesota
KW  - USA
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - Lake States of USA
KW  - cancer of the lymph nodes
KW  - cancers
KW  - lymphogranuloma
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Precancerous gastric lesions in a population at high risk of stomach cancer.
AU  - You, W. C.
AU  - Blot, W. J.
AU  - et al.
AU  - Li, J. Y. (
JO  - Cancer Research
JF  - Cancer Research
Y1  - 1993///
VL  - 53
IS  - Mar. 15
SP  - 1317
EP  - 1321
AD  - You, W. C.: (W.J. Blot) National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021510.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - "A population-based screening for detection of early cancers evaluated the prevalence of precancerous gastric lesions in an area in Shandong province, China, with one of the world's highest rates of stomach cancer. A total of 3433 residents aged 35 to 64 years received gastroscopical examinations with biopsies taken from standard locations. Chronic atrophic gastritis was nearly universal; less than 2% of the population had biopsies showing entirely normal mucosa or only superficial gastritis. Intestinal metaplasia was the most advanced lesion for 33% and gastric dysplasia for 20%, although the prevalence of each increased significantly with age. Intestinal metaplasia and gastric dysplasia were detected throughout the stomach, but the lesions were more pronounced along the lesser curvature, especially in the angulus and antrum. There was no sex difference in rates of chronic atrophic gastritis, but males had a slightly higher prevalence of intestinal metaplasia, a 1.6-fold increase in dysplasia, and a 3-fold excess of gastric cancer. The data quantify the extensiveness of gastric lesions likely to be involved in the natural history of stomach cancer in this high-risk population." The authors compare their findings with those from studies in Colombia and Japan. Their study of the residents of Linqu in Shandong continues in order to quantify progression rates and in the hope of developing [much needed] preventive measures. D.W. FitzSimons
KW  - neoplasms
KW  - stomach
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - gastric lesions
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021510&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytologic screening for oesophageal cancer: results from 12 877 subjects from a high-risk population in China.
AU  - Shen, Q.
AU  - Liu, S. F.
AU  - Dawsey, S. M.
AU  - Cao, J.
AU  - Zhou, B.
AU  - Wang, D. Y.
AU  - Cao, S. G.
AU  - Zhao, H. Z.
AU  - Li, G. Y.
AU  - Taylor, P. R.
AU  - Guo, W. D.
AU  - Liu, F. S.
AU  - Blot, W. J.
AU  - Li, J. Y.
AU  - Li, B.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1993///
VL  - 54
IS  - 2
SP  - 185
EP  - 188
SN  - 0020-7136
AD  - Shen, Q.: (S. M. Dawsey) Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952000405.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - In 1983, oesophageal balloon-cytology screening was performed to identify subjects eligible for 2 nutrition-intervention trials in Linxian, China; 12 877 subjects had cytology slides which were satisfactory for diagnosis. Of the 12 649 subjects with squamous-cell diagnoses, 31% were normal by Chinese cytologic criteria; 38% showed hyperplasia; 21% showed dysplasia 1; 6% showed dysplasia 2; 2% showed near-cancer; and 2% showed cancer. Of the 1471 subjects with columnar-cell diagnosis, 31% were normal; 44% showed hyperplasia; 16% showed dysplasia 1; 4% showed dysplasia 2; 2% showed near-cancer; and 3% showed cancer. Squamous dysplasia and cancer were more common among females than males, while columnar dysplasia and cancer showed male predominance. The prevalence of dysplasia and cancer of both cell types increased with age. The prevalence of squamous dysplasia was significantly higher than in earlier balloon-cytology screenings in Linxian, probably reflecting changes in cytologic classification.
KW  - epidemiology
KW  - neoplasms
KW  - oesophageal cancer
KW  - oesophagus
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - esophagus
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000405&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer incidence trends in women at high risk of human immunodeficiency virus (HIV) infection.
AU  - Rabkin, C. S.
AU  - Biggar, R. J.
AU  - Baptiste, M. S.
AU  - Abe, T.
AU  - Kohler, B. A.
AU  - Nasca, P.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1993///
VL  - 55
IS  - 2
SP  - 208
EP  - 212
SN  - 0020-7136
AD  - Rabkin, C. S.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007114.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref.
N2  - To determine the types and rates of tumours which may be associated with HIV infection in women, the authors used cancer incidence data from New York and northern New Jersey, USA. The authors examined changes in incidence of selected cancers in women aged 20-49 years and compared groups differing in incidence of AIDS. Black women were compared to white women in New York City and in the remainder of New York State; for cervical cancer, rates were also compared for Blacks and Whites in northern New Jersey. The incidence of Kaposi's sarcoma in women increased in New York City, beginning in 1982 for Blacks and in 1984 for Whites, but remained stable in the remainder of New York State. The incidence of non-Hodgkin's lymphoma in New York women doubled in Blacks after 1982 whereas incidence trends in Whites were unchanged. No consistent variation was seen in the incidence of Hodgkin's disease. Cervical cancer in New York and northern New Jersey Blacks declined over the same period by approximately 40% for invasive tumours and 50% for in situ lesions. The HIV epidemic is associated with substantial excesses of Kaposi's sarcoma and non-Hodgkin's lymphoma in women. The absence of Kaposi's sarcoma in upstate New York women suggest the existence of a geographically restricted co-factor(s) for Kaposi's sarcoma in addition to HIV. If HIV affected cervical cancer incidence through 1988, its impact was small compared to the striking decreases which followed widespread adoption of Papanicolaou screening.
KW  - disease prevalence
KW  - human immunodeficiency viruses
KW  - infections
KW  - neoplasms
KW  - women
KW  - New Jersey
KW  - New York
KW  - North America
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007114&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tobacco use and nasopharyngeal carcinoma in a cohort of US veterans.
AU  - Chow, W. H.
AU  - McLaughlin, J. K.
AU  - Hrubec, Z.
AU  - Nam, J. M.
AU  - Blot, W. J.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1993///
VL  - 55
IS  - 4
SP  - 538
EP  - 540
SN  - 0020-7136
AD  - Chow, W. H.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19952007324.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
N2  - The risk of nasopharyngeal carcinoma (NPC), a relatively rare neoplasm in the USA, was examined in relation to tobacco use in a cohort of nearly 250 000 USA veterans whose mortality experience was followed for 26 years. A total of 48 NPC deaths were identified during the follow-up period. Current smokers had a nearly 4-fold increase in risk of NPC compared with non-users of any tobacco, with risk increasing to 6.4 among those smoking more than 2 packs daily. After adjustment for age and number of cigarettes smoked, risks were inversely associated with age at starting to smoke, with the highest risk observed among those who started smoking before age 15, although no clear trend associated with duration of smoking was observed. Former cigarette smokers had a small excess risk of NPC, but no association was detected for cigar/pipe users. This study adds strong evidence to the increasing literature linking cigarette smoking to NPC.
KW  - nasopharynx
KW  - neoplasms
KW  - tobacco smoking
KW  - veterans
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - war veterans
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007324&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts.
AU  - Cardellina, J. H., II
AU  - Munro, M. H. G.
AU  - Fuller, R. W.
AU  - Manfredi, K. P.
AU  - Mckee, T. C.
AU  - Tischler, M.
AU  - Bokesch, H. R.
AU  - Gustafson, K. R.
AU  - Beutler, J. A.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1993///
VL  - 56
IS  - 7
SP  - 1123
EP  - 1129
SN  - 0163-3864
AD  - Cardellina, J. H., II: Laboratory of Drug Discovery and Development, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19940307849.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Botanical Pesticides; Horticultural Science
N2  - A chemical screening protocol, utilizing various solid-phase extraction cartridges, has been developed to screen aqueous extracts from terrestrial plants, cyanobacteria, and marine invertebrates and algae for anti-human immunodeficiency virus activity, and to assist in the prioritization of these extracts for further investigation.
KW  - antiviral plants
KW  - antiviral properties
KW  - extracts
KW  - human immunodeficiency viruses
KW  - plant composition
KW  - plant extracts
KW  - algae
KW  - cyanobacteria
KW  - invertebrates
KW  - plants
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - eukaryotes
KW  - Bacteria
KW  - prokaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - animals
KW  - anti-viral properties
KW  - bacterium
KW  - chemical constituents of plants
KW  - human immunodeficiency virus
KW  - Plant Composition (FF040) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biological Resources (Animal) (PP710) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Two new cytotoxic chalcones from Calythropsis aurea.
AU  - Beutler, J. A.
AU  - Cardellina, J. H., II
AU  - Gray, G. N.
AU  - Prather, T. R.
AU  - Shoemaker, R. H.
AU  - Boyd, M. R.
AU  - Lin, C. M.
AU  - Hamel, E.
AU  - Cragg, G. M.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1993///
VL  - 56
IS  - 10
SP  - 1718
EP  - 1722
SN  - 0163-3864
AD  - Beutler, J. A.: Laboratory of Drug Discovery Research & Development, Natural Products Branch, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19950303045.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Horticultural Science
N2  - The crude extract of C. aurea produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Two new chalcones, calythropsin and dihydrocalythropsin, were isolated from roots of C. aurea (collected 70 km north of Geraldton, Western Australia), following cytotoxicity-guided fractionation. Their structures were elucidated from spectral data. The most active compound, calythropsin, was weakly cytotoxic, and was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.
KW  - chalcones
KW  - chemical structure
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - medicinal plants
KW  - mitogens
KW  - plant composition
KW  - plant extracts
KW  - roots
KW  - spectral analysis
KW  - tubulin
KW  - Australia
KW  - Myrtaceae
KW  - Myrtales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - Calythropsis aurea
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950303045&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of phenylpropanolamine on energy expenditure and weight loss in overweight women.
AU  - Alger, S.
AU  - Larson, K.
AU  - Boyce, V. L.
AU  - Seagle, H.
AU  - Fontvieille, A. M.
AU  - Ferraro, R. T.
AU  - Rising, R.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993///
VL  - 57
IS  - 2
SP  - 120
EP  - 126
SN  - 0002-9165
AD  - Alger, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19931463761.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - The effect of phenylpropanolamine (PPA), a non-catecholamine sympathomimetic weight-loss agent, on energy expenditure (EE) and substrate oxidation was estimated in a respiratory chamber in 24 overweight women, 18 to 49 years old, after 4 days of treatment (PPA or placebo) during weight maintenance and after 7 weeks of treatment on a hypoenergetic diet (70% of estimated baseline 24-h EE). 12 women (37±2 years old, 74±6 kg, 33±1% body fat) were randomly assigned to the PPA group (75 mg osmotic release oral system (OROS)-PPA daily) and 12 (38±2 years old, 79±1 kg, 37±1% body fat) to the placebo group. Baseline measurements of 24-h EE (7849±226 vs. 7834±142 kJ/day), basal metabolic rate (BMR) and 24-h respiratory quotient (RQ) were comparable between PPA and placebo groups. After 4 days of treatment, there was no significant effect of PPA on 24-h EE, BMR and 24-h RQ compared with placebo. During the 7-week diet period, however, the PPA group (n=8) had greater weight loss than the placebo group (n=10): -5.0±0.5 vs. -3.0±0.4 kg (P&lt;0.05). The changes in 24-h EE and 24-h RQ during the 7 weeks were not different between the groups. It is concluded that weight loss is enhanced by OROS-PPA, but this change was not explained by changes in 24-h EE or 24-h RQ. The small number of subjects may have hindered detection of subtle differences in energy metabolism.
KW  - drug therapy
KW  - energy exchange
KW  - obesity
KW  - weight reduction
KW  - Women
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931463761&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification, isolation, and characterization of naturally-occurring Trypanosoma cruzi variants.
AU  - McDaniel, J. P.
AU  - Dvorak, J. A.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1993///
VL  - 57
IS  - 2
SP  - 213
EP  - 222
SN  - 0166-6851
AD  - McDaniel, J. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930803009.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology; Tropical Diseases
N2  - Naturally occurring DNA variants of the single-cell-derived Y-02 stock of T. cruzi were discovered during a routine assay of the stock. Three DNA variant types were isolated. One type was indistinguishable from the parental Y-02 stock on the basis of total DNA/cell. The other 2 types contained approximately 30% and 70% more DNA/cell than the parental Y-02 stock. Both the nucleus and kinetoplast were involved in the DNA content differences. The increase in DNA/cell was not G-C- or A-T-specific and was unrelated to the developmental stage of the parasite. Epimastigote population doubling times, isoenzymes, and schizodeme analyses could not differentiate the variant stocks. However, marked karyotype polymorphisms were observed by pulse-field gel electrophoresis, and restriction-fragment-length-polymorphisms were detected in hybridizations of some endonuclease-restricted samples to the spliced leader probe. It is postulated that the Y-02 variants are genetic homologues. The ability to form viable hybrids or aneuploids provides T. cruzi with a mechanism to survive environmental stress, promote intra-specific heterogeneity and generate the diversity observed in the presentation and course of Chagas' disease.
KW  - Chemotaxonomy
KW  - culture techniques
KW  - DNA
KW  - Human diseases
KW  - Molecular genetics
KW  - parasites
KW  - Polymorphism
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - biochemical genetics
KW  - biochemical taxonomy
KW  - deoxyribonucleic acid
KW  - DNA polymorphism
KW  - DNA variants
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930803009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Problems with estimating vitamin C intakes.
AU  - Sinha, R.
AU  - Block, G.
AU  - Taylor, P. R.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993///
VL  - 57
IS  - 4
SP  - 547
EP  - 550
SN  - 0002-9165
AD  - Sinha, R.: EPN Room 443, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941400154.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition; Potatoes
N2  - The vitamin C content of foods was examined from 2 US national databases and new values were obtained by HPLC. HPLC values were lower in 4 of the 5 highest vitamin C contributors to the US diet (orange juice, grapefruit, tomatoes and tomato juice, and potatoes), as well as in broccoli, red peppers, and cooked collard and mustard greens, compared with values from the other databases. When HPLC values were substituted in the Health Habits and History Questionnaire, the resulting estimates of dietary intake of vitamin C in 2 studies were lower. Despite these lower estimates of absolute intake, in one study the correlation between dietary vitamin C and plasma ascorbic acid was similar. In conclusion, the accuracy of the vitamin C content of food is important for estimating the absolute amount of vitamin C intake in the population but may not change the ranking of people in epidemiological studies.
KW  - ascorbic acid
KW  - databases
KW  - diet studies
KW  - estimation
KW  - food composition
KW  - HPLC
KW  - intake
KW  - nutrition
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - data banks
KW  - high performance liquid chromatography
KW  - United States of America
KW  - vitamin C
KW  - Information and Documentation (CC300) 
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400154&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and characterization of differentially expressed genes from in vitro-grown 'amastigotes' of Leishmania donovani.
AU  - Joshi, M.
AU  - Dwyer, D. M.
AU  - Nakhasi, H. L.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1993///
VL  - 58
IS  - 2
SP  - 345
EP  - 354
SN  - 0166-6851
AD  - Joshi, M.: Laboratory of Biochemistry, Division of Biochemistry and Biophysics, CBER, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930804493.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - An axenic culture system was used which permits the continuous generation and cycling of L. donovani from promastigotes to 'amastigotes' in vitro. cDNA libraries were constructed from poly(A)+ RNA isolated from both the promastigote and amastigote forms. Using differential cDNA hybridization techniques, 3 unique cDNA clones (P17, A41 and A45) were isolated from the amastigote library. To assess whether these clones were differentially expressed by the promastigotes or amastigotes, they were hybridized to RNA isolated from each of these parasite forms in Northern and slot-blots. Results of these analyses showed that amastigotes had about 2-fold higher levels of the A41 and A45 RNAs compared to the promastigotes. Promastigotes showed about 2-fold higher levels of the P17 RNA than amastigotes. Nucleotide sequence analysis and comparison with those in Gene bank, revealed that the 3 cDNAs represent unique leishmanial genes. Comparison of the deduced amino acid sequences revealed that: P17 open reading frame (ORF) had significant similarity with a soybean ribosomal protein S11; A41 ORF with a Bacillus subtilis spore germination gene (gerC) and A45 ORF with yeast stress-inducible protein (STI1). It is noted that, of the 3 cDNAs identified, the A45-encoded protein was recognized by sera from patients with clinically active visceral leishmaniasis and was encoded by a single copy gene.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The authors report the isolation of 3 cDNA clones encoding mRNAs that are differentially expressed by in vitro derived pro- and "amastigotes". One of these mRNA encodes a protein that was recognized by sera from patients with visceral leishmaniasis.Carolyn A. Brown
KW  - amastigotes
KW  - complementary DNA
KW  - Developmental stages
KW  - Genes
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - promastigotes
KW  - Leishmania donovani
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - gene cloning
KW  - growth phase
KW  - ribosomal protein
KW  - stress-inducible protein
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804493&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and expression of the gene for Plasmodium falciparum transmission-blocking target antigen, Pfs230.
AU  - Williamson, K. C.
AU  - Criscio, M. D.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1993///
VL  - 58
IS  - 2
SP  - 355
EP  - 358
SN  - 0166-6851
AD  - Williamson, K. C.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804494.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The Pfs230 gene was cloned, sequenced and expressed in Escherichia coli. In addition to 3 tryptic peptides that were sequenced, the deduced amino acid sequence of Pfs230 coded for a 363 000 MW polypeptide with 5 distinct characteristics: consistent with Pfs230 being a non-integral membrane protein, there is a presumptive signal sequence at the amino terminus; starting at amino acid 280, there are 25 contiguous E residues; beginning with amino acid 379, a 4 amino acid (E-E-V-G) repeat is present tandemly 8 times followed by 4 copies of an 8 amino acid repeat (E-E-V-G-E-E/G-E/V-G); there are 3 regions of highly negative net charge, including amino acids 273-325, which contains the 25 E residues, amino acids 1147-1205, and amino acids 1604-1668; there are 6 copies of a 7-cysteine motif.
KW  - antigens
KW  - Genes
KW  - Human diseases
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - transmission blocking immunity
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - gene cloning
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804494&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The correlation between two dietary assessments of carotenoid intake and plasma carotenoid concentrations: application of carotenoid food-composition database.
AU  - Forman, M. R.
AU  - Lanza, E.
AU  - Yong, L. C.
AU  - Holden, J. M.
AU  - Graubard, B. I.
AU  - Beecher, G. R.
AU  - Melitz, M.
AU  - Brown, E. D.
AU  - Smith, J. C.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993///
VL  - 58
IS  - 4
SP  - 519
EP  - 524
SN  - 0002-9165
AD  - Forman, M. R.: Cancer Prevention Studies Branch, Cancer Prevention Research Program, Division of Cancer Prevention and Control, National Cancer Institute, Rockville, MD 20892, USA.
N1  - Accession Number: 19941405849.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Human Nutrition
N2  - A newly available carotenoid food-composition database providing specific carotenoid values for &gt;2300 foods was linked to dietary data on 57 male nonsmokers to examine the association between dietary carotenoid intake and plasma carotenoid concentrations during 3 weeks of free-living. Carotenoid intake was estimated from a food-frequency questionnaire (FFQ) and 7 days of food diaries (FD) with concurrent analysis of plasma carotenoid concentrations. After adjustment for energy intake, percentage of energy from alcohol, and plasma lipid concentrations, significant diet-plasma correlations for the FFQ and the FD included α-carotene, β-carotene, β-cryptoxanthin, lutein and lycopene. Dietary carotenoid intakes were associated with plasma carotenoid concentrations for all the carotenoids except for β-carotene when food diaries were used whereas the diet-plasma correlation for the provitamin A carotenoids were consistently significant when the FFQ was used.
KW  - blood
KW  - carotenoids
KW  - databases
KW  - diet study techniques
KW  - food composition
KW  - intake
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - data banks
KW  - tetraterpenoids
KW  - Food Composition and Quality (QQ500) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1).
AU  - Miller, L. H.
AU  - Roberts, T.
AU  - Shahabuddin, M.
AU  - McCutchan, T. F.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1993///
VL  - 59
IS  - 1
SP  - 1
EP  - 14
SN  - 0166-6851
AD  - Miller, L. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804760.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - All published sequences of Plasmodium falciparum merozoite surface protein (MSP-1) were aligned, identifying errors, resequencing a portion of one parasite clone, and identifying probable duplicate sequences of 4 pairs of parasite clones. The sequences are presented in a fashion that facilitates the study of variation and its potentially diverse origins. The original dimorphic sequences described by Tanabe et al. have been modified to include only common sequences throughout the entire gene. The extension of the dimorphic region of the 5′ end of block 3 brings into question the involvement of intragenic crossover as the major mechanism generating allelic diversity. Additional diversity developed from point mutations and recombination in certain regions of the gene.
KW  - antigens
KW  - Genes
KW  - Human diseases
KW  - merozoites
KW  - Molecular genetics
KW  - Nucleotide sequences
KW  - parasites
KW  - proteins
KW  - surface proteins
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - membrane proteins
KW  - merozoite surface protein
KW  - sequence analysis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804760&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation, structure and synthesis of conocurvone, a potent, novel HIV-inhibitory naphthoquinone trimer from Conospermum species [in particular C. incurvum].
AU  - Decosterd, L. A.
AU  - Parsons, I. C.
AU  - Gustafson, K. R.
AU  - Cardellina, J. H., II
AU  - McMahon, J.
AU  - Cragg, G. M.
AU  - Murata, Y.
AU  - Pannell, L. K.
AU  - Steiner, J. R.
AU  - Clardy, J.
AU  - Boyd, M.
JO  - Planta Medica
JF  - Planta Medica
Y1  - 1993///
VL  - 59
IS  - 7
SP  - A581
EP  - A581
SN  - 0032-0943
AD  - Decosterd, L. A.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Programm, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19940307909.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 1 ref. Subject Subsets: Botanical Pesticides; Horticultural Science
KW  - antiviral plants
KW  - antiviral properties
KW  - biosynthesis
KW  - chemical structure
KW  - human immunodeficiency viruses
KW  - inhibitors
KW  - medicinal plants
KW  - plant composition
KW  - quinones
KW  - Australia
KW  - plants
KW  - Proteaceae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - eukaryotes
KW  - Proteales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - Conospermum
KW  - Conospermum incurvum
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - Medicinal plant research
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Non-wood Forest Products (KK540) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940307909&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Restriction polymorphisms and fingerprint patterns from an interspersed repetitive element of Plasmodium falciparum DNA.
AU  - Dolan, S. A.
AU  - Herrfeldt, J. A.
AU  - Wellems, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1993///
VL  - 61
IS  - 1
SP  - 137
EP  - 142
SN  - 0166-6851
AD  - Dolan, S. A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940802257.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology; Tropical Diseases
N2  - A recombinant DNA clone, pC4.H32, identifies distinguishable restriction fragment patterns from different Plasmodium falciparum clones. Analysis of these DNA fingerprint patterns from parasites cultivated over several years and from progeny of a P. falciparum cross showed the fingerprints to be mitotically and meiotically stable. Restriction fragments from the parents of the cross possessed sufficient polymorphism and number to generate 14 unique fingerprint patterns in 16 independent recombinant progeny. The pC4.H32 insert contains a 0.5-kb imperfectly repeated sequence found in subtelomeric regions of multiple chromosomes. Restriction site variations both within and outside of the 0.5-kb repeat contribute to the fingerprint polymorphisms. It is concluded that fingerprint analysis can serve to type P. falciparum clones and can detect mislabelling and cross-contamination of parasite stocks.
KW  - chemotaxonomy
KW  - DNA
KW  - DNA fingerprinting
KW  - human diseases
KW  - molecular genetics
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - biochemical taxonomy
KW  - deoxyribonucleic acid
KW  - fingerprint patterns
KW  - restriction polymorphism
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802257&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enhancement of oxidative response and damage caused by human neutrophils to Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon.
AU  - Roilides, E.
AU  - Uhlig, K.
AU  - Venzon, D.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 4
SP  - 1185
EP  - 1193
SN  - 0019-9567
AD  - Roilides, E.: T. J. Walsh, Pediatric Branch, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931214402.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - To investigate the role of granulocyte colony-stimulating factor (G-CSF) and gamma interferon (IFN-γ) against A. fumigatus, their effects on the oxidative burst and capacity of normal human PMNs to damage hyphae were studied. G-CSF enhanced PMN oxidative burst measured as superoxide anion (O2-) production in response to N-formylmethionyl leucyl phenylalanine, serum opsonized hyphae and non-opsonized hyphae by 75, 37 and 24%, respectively, compared with control PMNs (P&lt;0.015). IFN-γ also induced increases of 52, 71 and 96%, respectively, in response to the same stimuli (P&lt;0.006). Also, the capacity of PMNs to damage hyphae as measured by the 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide colorimetric metabolic assay was significantly enhanced by G-CSF and IFN-γ (P&lt;0.01 and &lt;0.05, respectively). The enhancement was achieved irrespective of serum opsonization of the hyphae, indicating upregulatory actions of the 2 cytokines on signal pathways specific for opsonized and non-opsonized hyphae. The combination of the 2 cytokines exhibited an additive effect at the higher concn compared with the effects of the cytokines alone (P&lt;0.05). Pretreatment of PMNs with protein synthesis inhibitors showed that IFN-γ activates PMN function through transcriptional regulation, whereas the effect of G-CSF does not require new proteins. It is suggested that G-CSF and IFN-γ have regulatory roles in host defence against Aspergillus hyphae, irrespective of serum opsonization, and a potential utility as adjuncts for prevention and possible treatment of invasive aspergillosis.
KW  - cytokines
KW  - immunology
KW  - neutrophils
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Schistosoma japonicum-infected mice show reduced hepatic fibrosis and eosinophilia and selective inhibition of interleukin-5 secretion by CD4+ cells after treatment with anti-interleukin-2 antibodies.
AU  - Cheever, A. W.
AU  - Xu, Y. H.
AU  - Sher, A.
AU  - Finkelman, F. D.
AU  - Cox, T. M.
AU  - Macedonia, J. G.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 4
SP  - 1288
EP  - 1292
SN  - 0019-9567
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806865.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2.  Subject Subsets: Helminthology
N2  - Schistosoma japonicum-infected mice (strain C3H/HeN) were injected with antibodies to interleukin-2 (IL-2) and/or IL-2 receptor to clarify the role of IL-2 on the granulomatous reaction around schistosome eggs in the liver. Granulomata were of normal or slightly increased size in animals subjected to IL-2 blockade, but hepatic fibrosis was markedly decreased in treated animals 10 weeks after infection. Anti-IL-2 treatment significantly decreased the in vitro secretion of IL-5 by antigen-stimulated spleen cells, and peripheral eosinophilia and tissue eosinophilia were diminished. Secretion of IL-2, IL-4, and gamma interferon was unaffected. The results indicate that IL-2 is not an essential determinant of granuloma size in S. japonicum-infected mice but that, as in Schistosoma mansoni infection, the development of hepatic fibrosis is critically dependent on IL-2 levels and granuloma size and hepatic fibrosis are differentially regulated.
KW  - Cytokines
KW  - Experimental infections
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - Interferon
KW  - Interleukin 2
KW  - Interleukin 4
KW  - Interleukin 5
KW  - Interleukins
KW  - Laboratory animals
KW  - parasites
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - Rodents
KW  - Schistosoma japonicum
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806865&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi.
AU  - Whitmire, W. M.
AU  - Garon, C. F.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 4
SP  - 1460
EP  - 1467
SN  - 0019-9567
AD  - Whitmire, W. M.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950503050.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 308067-57-4.  Subject Subsets: Medical & Veterinary Entomology
N2  - Lymphocyte blastogenesis assays and immunoblotting were used to investigate and compare murine B-cell responses to preparations of extracellular membrane blebs (BAg) and spirochaetes (Ag) of B. burgdorferi. Immunoblotting BAg, Ag and medium control preparations with serum from naive and infected C57BL/10 mice revealed that BAg and Ag had similar specific reactivity profiles except that major antigens of 83, 60 and 41 kDa were detected in Ag but not in BAg. It was determined that 1 µg (dry weight) of Ag contained 0.0051 and 0.0063 µg of outer surface proteins A (OspA) and OspB, respectively, whereas 1 µg (dry weight) of BAg contained 0.0024 µg of OspA and 0.0015 µg of OspB. Both BAg and Ag caused blastogenesis in cultures of spleen cells from both groups of mice, but BAg-stimulated lymphocytes exhibited significantly greater (P¬&lt; 0.05) blastogenesis after 2 or 6 days of culture than did lymphocytes stimulated by Ag or medium control. Flow cytometry and antibody capture ELISAs identified responding lymphocytes as B cells which secreted polyclonal IgM but not IgG or IgA. Treatment of BAg and lipopolysaccharide controls with polymyxin B resulted in as much as 20.7 and 54.3% mean decreases in blastogenesis, respectively. Fractionation of BAg or Ag by ultracentrifugation before culture with spleen cells from naive mice indicated that B-cell blastogenesis was probably associated with spirochaetal membranes. The results demonstrated that specific humoral responses are directed towards extracellular membrane blebs which lack the 83-, 60- and 41-kDa antigens of intact spirochaetes and that blebs also possess significant nonspecific mitogenic activity for murine B cells. This activity was not due entirely to typical lipopolysaccharide or OspA and OspB lipoproteins.
KW  - antigens
KW  - B lymphocytes
KW  - IgM
KW  - immune response
KW  - immunoglobulins
KW  - laboratory animals
KW  - Lyme disease
KW  - Borrelia burgdorferi
KW  - mice
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - B cells
KW  - bacterium
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells.
AU  - Heinzen, R. A.
AU  - Hayes, S. F.
AU  - Peacock, M. G.
AU  - Hackstadt, T.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 5
SP  - 1926
EP  - 1935
SN  - 0019-9567
AD  - Heinzen, R. A.: Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59830, USA.
N1  - Accession Number: 19950503052.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 9064-37-3.  Subject Subsets: Medical & Veterinary Entomology
N2  - Members of the spotted fever group (SFG) of rickettsiae spread rapidly from cell to cell by an unknown mechanism(s). Staining of R. rickettsii-infected Vero cells with rhodamine phalloidin demonstrated unique actin filaments associated with one pole of intracellular rickettsiae. F-actin tails &gt;70 µm in length were seen extending from rickettsiae. Treatment of infected cells with chloramphenicol eliminated rickettsia-associated F-actin tails, suggesting that de novo protein synthesis of one or more rickettsial proteins is required for tail formation. Rickettsiae were coated with F-actin as early as 15 min postinfection, and tail formation was detected by 30 min. A survey of virulent and avirulent species within the SFG rickettsiae demonstrated that all formed actin tails entirely or exhibited only very short tails. Transmission electron microscopy demonstrated fibrillar material in close association with R. rickettsii but not R. prowazekii. Biochemical evidence that actin polymerization plays a role in movement was provided by showing that transit of R. rickettsii from infected cells into cell culture medium was inhibited by treatment of host cells with cytochalasin D. These data suggest that the cell-to-cell transmission of SFG rickettsiae may be aided by induction of actin polymerization in a fashion similar to that described for Shigella flexneri and Listeria monocytogenes.
KW  - actin
KW  - cells
KW  - fluorescence
KW  - infection
KW  - polymerization
KW  - Rickettsia australis
KW  - Rickettsia conorii
KW  - Rickettsia montanensis
KW  - Rickettsia parkeri
KW  - Rickettsia prowazekii
KW  - Rickettsia rickettsii
KW  - Rickettsia typhi
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - Rickettsia montana
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503052&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An approach to development of specific T-lymphocyte lines by use of preprocessed antigens in Plasmodium vinckei vinckei murine malaria.
AU  - Wasserman, G. M.
AU  - Kumar, S.
AU  - Ahlers, J.
AU  - Ramsdell, F.
AU  - Berzofsky, J. A.
AU  - Miller, L. H.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 5
SP  - 1958
EP  - 1963
SN  - 0019-9567
AD  - Wasserman, G. M.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930805899.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2.  Subject Subsets: Protozoology
N2  - The development of parasite-specific T-cell lines represents one approach to the potential identification of relevant immunogens in erythrocytic malarial infection. However, the use of parasitized-erythrocyte lysates as antigens inhibits the proliferation of T cells. To circumvent this problem, antigen-presenting cells (APCs) were pre-incubated from spleens of malaria-naive, BALB/c mice with a Plasmodium vinckei vinckei (ATCC 30091) (referred to as P. vinckei)-parasitized erythrocyte lysate. APCs were subsequently irradiated and washed prior to being incubated with T lymphocytes from P. vinckei-immune, histocompatible mice. After 8 to 10 cycles of antigenic stimulation and rest, 2 T-cell lines were analyzed. Both lines were predominantly CD4+. Proliferation assays demonstrated marked lymphocyte blastogenesis to syngeneic but not allogeneic APCs that had preprocessed malarial antigen. Antigen incubated directly with T cells and nonpulsed APCs in vitro did not result in T-cell proliferation. Assays of interleukin-2 (IL-2), IL-4, IL-5 and gamma interferon were compatible with one cell line being predominantly TH1 and the other being TH2. Thus, APCs that have preprocessed malarial antigen and are free of extraneous parasite material induce highly reactive, antigen-specific, major histocompatibility complex-restricted T-cell lines that functionally appear capable of inducing humoral and/or cell-mediated immunity.
KW  - antigens
KW  - Cytokines
KW  - Experimental infections
KW  - immune response
KW  - Interferon
KW  - Interleukin 2
KW  - Interleukin 4
KW  - Interleukin 5
KW  - Laboratory animals
KW  - parasites
KW  - T lymphocytes
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - Plasmodiidae
KW  - Plasmodium vinckei
KW  - protozoa
KW  - Rodents
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of expression of major outer surface proteins in Borrelia burgdorferi.
AU  - Margolis, N.
AU  - Rosa, P. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 5
SP  - 2207
EP  - 2210
SN  - 0019-9567
AD  - Margolis, N.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950503055.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A B. burgdorferi clone (CA-11 2A) which does not synthesize the major outer surface proteins OspA and OspB was characterized. While the osp operon is intact and capable of expression, no mRNA transcript is detectable in this clone. These results suggest that osp operon expression in the B. burgdorferi clone can be regulated at the level of transcription.
KW  - clones
KW  - gene expression
KW  - molecular genetics
KW  - proteins
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variability of osp genes and gene products among species of Lyme disease spirochetes.
AU  - Marconi, R. T.
AU  - Konkel, M. E.
AU  - Garon, C. F.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 6
SP  - 2611
EP  - 2617
SN  - 0019-9567
AD  - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19942025445.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - A comparison of the osp operon in 24 Lyme disease isolates, including representatives from each of the three established species, Borrelia burgdorferi, Borrelia garinii, and group VS461, was conducted. Several properties were assessed to determine whether the variability observed in this operon was reflective of the species of the isolate. At the transcriptional level, start site and Northern (RNA) blot analyses were conducted. B. garinii and VS461 group isolates were found to possess an untranslated leader sequence 6 nucleotides longer than that observed in B. burgdorferi isolates. By Northern blot analyses all Lyme disease isolates, except the B. garinii isolate VS102, were found to produce a polycistronic full-length ospAB message. Isolate VS102 produced a truncated message lacking the ospB portion of the transcript. Southern blot analyses suggest that the deletion occurred at the DNA level and was not due to a posttranscriptional event. Analysis of the outer surface proteins by two-dimensional gel electrophoresis demonstrated that the OspB isoelectric points were variable, with the OspB of B. garinii isolates exhibiting a pronounced acidic shift. The reactivity of different isolates to OspA and -B monoclonal antibodies and to a hyperimmune anti-ospAB serum was also variable. The results presented here demonstrate genotypic and phenotypic heterogeneity in the osp operon at both the inter- and intraspecies levels. The results have implications concerning the use of the osp genes or their gene products in the development of a Lyme disease vaccine, as diagnostic markers of Lyme disease, and in subtyping of Lyme disease isolates. AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A comparison of the osp operon in 24 Lyme disease isolates (from the USA, Europe and Japan), including representatives from Borrelia burgdorferi s.s, B. garinii and group VS461 [B. afzelii], was conducted. Several properties were assessed to determine whether the variability observed in this operon was reflective of the species of the isolate. At the transcriptional level, start site and Northern (RNA) blot analyses were conducted. B. garinii and VS461 group isolates were found to possess an untranslated leader sequence 6 nucleotides longer than that observed in B. burgdorferi isolates. By Northern blot analyses all Lyme disease isolates, except the B. garinii isolate VS102 (from Ixodes ricinus in Switzerland), were found to produce a polycistronic full-length ospAB message. Isolate VS102 produced a truncated message lacking the ospB portion of the transcript. Southern blot analyses suggest that the deletion by 2-dimensional gel electrophoresis demonstrated that the OspB isoelectric points were variable, with the OspB of B. garinii isolates exhibiting a pronounced acidic shift. The reactivity of different isolates to OspA and -B monoclonal antibodies and to a hyperimmune anti-ospAB serum was also variable. The results demonstrated genotypic and phenotypic heterogeneity in the osp operon at both the inter- and intraspecies levels. The results have implications concerning the use of the osp genes or their gene products in the development of a Lyme disease vaccine, as diagnostic markers of Lyme disease, and in subtyping of Lyme disease isolates.
KW  - aetiology
KW  - DNA
KW  - genes
KW  - genetic analysis
KW  - genetic variation
KW  - immunoblotting
KW  - Lyme disease
KW  - molecular genetics
KW  - Northern blotting
KW  - operons
KW  - proteins
KW  - taxonomy
KW  - Borrelia
KW  - Borrelia afzelii
KW  - Borrelia burgdorferi
KW  - Borrelia garinii
KW  - Spirochaetales
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Borrelia
KW  - bacterium
KW  - biochemical genetics
KW  - causal agents
KW  - deoxyribonucleic acid
KW  - etiology
KW  - genetic variability
KW  - genospecies
KW  - genotypic variability
KW  - genotypic variation
KW  - lyme borreliosis
KW  - systematics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevention of corticosteroid-induced suppression of human polymorphonuclear leukocyte-induced damage of Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon.
AU  - Roilides, E.
AU  - Uhlig, K.
AU  - Venzon, D.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1993///
VL  - 61
IS  - 11
SP  - 4870
EP  - 4877
SN  - 0019-9567
AD  - Roilides, E.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931251554.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The potential preventive utility of granulocyte colony-stimulating factor (G-CSF) and γ-interferon (IFN-γ) on the deleterious effect of corticosteroids on neutrophil (PMN) antifungal function was investigated. The effects of hydrocortisone (HCS) and dexamethasone (DXS) on PMN-induced damage of A. fumigatus hyphae were studied with or without pretreatment of PMNs with G-CSF and IFN-γ. PMNs treated with HCS (≥3000 μM) or DXS (≥10 μM) during a 2-h colorimetric tetrazolium metabolic assay showed suppressed percentage of hyphal damage (P&lt;0.02). Both HCS (≥30 μM) and DXS (≥1 μM) significantly suppressed oxidative burst measured as superoxide anion release by PMNs in response to opsonized and non-opsonized hyphae as well as to N-formylmethionyl leucyl phenylalanine. Pretreatment of PMNs with G-CSF (4000 U/ml) and/or IFN-γ (100 and 1000 U/ml) for 90 min prevented the suppression of hyphal damage that occurred in the presence of HCS (3000 μM; P&lt;0.01) or DXS (10 μM; P≤0.001). G-CSF (4000 U/ml) and IFN-γ (100 U/ml) combined had an additive effect on increasing the antifungal activity of HCS-treated but not of DXS-treated PMNs compared with IFN-γ alone (P=0.015). It is concluded that corticosteroids impair PMN function in response to A. fumigatus and that G-CSF and IFN-γ prevent this impairment.
KW  - cytokines
KW  - immunology
KW  - neutrophils
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Strain polymorphism of Plasmodium falciparum transmission-blocking target antigen Pfs230.
AU  - Williamson, K. C.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1993///
VL  - 62
IS  - 1
SP  - 125
EP  - 127
SN  - 0166-6851
AD  - Williamson, K. C.: Molecular Vaccine Section, Bldg. 4 Rm B1-37, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940801099.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The genomic sequence of Pfs230 from the 7G8 strain of Plasmodium falciparum (a chloroquine-resistant clone from a Brazilian isolate) was determined and compared to the cDNA sequence of the 3D7 strain (a chloroquine-sensitive clone from isolate NF54, thought to be of African origin). The complete Pfs230 open reading frame was continuous in the 7G8 genomic clones, indicating it is encoded by a single exon. The genomic structure of 3D7 appeared to be the same as 7G8 by restriction enzyme analysis. Also, introns were not found at the 5′ or 3′ end of the gene from 3D7, by PCR. The nucleotide sequences of 3D7 and 7G8 were 99.8% identical. There were 25 nucleotide differences in a total of 9417 nucleotides. The extent of polymorphism of Pfs230 was also studied in other isolates (CAMP, LF4 and LE5).
KW  - Antigens
KW  - genes
KW  - human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - polymorphism
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - Transmission-blocking target antigen Pfs230
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A cohort study in southern China of tin miners exposed to radon and radon decay products.
AU  - Xuan, X. Z.
AU  - Lubin, J. H.
AU  - et al.
AU  - Li, J. Y. (
JO  - Health Physics
JF  - Health Physics
Y1  - 1993///
VL  - 64
IS  - 2
SP  - 120
EP  - 131
SN  - 0017-9078
AD  - Xuan, X. Z.: (J.H. Lubin) Biostatistics Branch, National Cancer Institute, EPN, Room 403, 6130 Executive Boulevard, Rockville, MD 20892, USA.
N1  - Accession Number: 19932021620.  Publication Type: Journal Article.  Language: English.  Registry Number: 10043-92-2, 7440-31-5.  Subject Subsets: Public Health
N2  - ... [The authors report a large] historical cohort study of male employees of the Yunnan Tin Corporation in southern China. The cohort consists of 17 143 workers with 175 143 person years of observation and 981 lung cancer events. Eighty percent of the workers were employed underground and exposed to radon. The excess relative risk increased linearly with exposure, rising 0.6% per working level month (95% confidence interval = 0.4-0.8). In the mines, workers were also exposed to arsenic-containing dusts. Adjustment for arsenic exposure, a known lung carcinogen, reduced the effect of radon exposure to 0.2% per working level month (95% confidence interval = 0.1-0.2). The excess relative risk/working level month declined significantly with attained age and with radon exposure rate as measured by the cumulative working level month divided by duration of exposure. It also declined significantly with years from last exposure and with time since exposure, but these declines were consistent only after adjustment for arsenic exposure. In this cohort, 41% of the underground workers were first exposed when &lt;15 years old; however, lung cancer risk did not vary consistently with age at first radon exposure. A joint analysis of radon exposure and smoking status (smoker vs. nonsmoker) rejected both an additive and a multiplicative association; the relationship was consistent with an intermediate association. [Data on smoking were missing for 4088 subjects but there were very few non-smoking non-radon-exposed cases of lung cancer.] AS
KW  - exposure
KW  - miners
KW  - occupational medicine
KW  - occupations
KW  - radiation
KW  - radon
KW  - tin
KW  - workers
KW  - Asia
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - People's Republic of China
KW  - tin miners
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity.
AU  - Falgout, B.
AU  - Miller, R. H.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 4
SP  - 2034
EP  - 2042
SN  - 0022-538X
AD  - Falgout, B.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950507531.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
N2  - Most proteolytic cleavages in the nonstructural protein (NS) region of the flavivirus polyprotein are effected by a virus-encoded protease composed of 2 viral proteins, NS2B and NS3. The N-terminal 180-amino-acid-region of NS3 includes sequences with homology to the active sites of serine proteases, and there is evidence that this portion of NS3 can mediate proteolytic cleavages. In contrast, nothing is known about required sequences in NS2B. A series of deletion mutations were constructed in the NS2B portion of plasmid pTM/NS2B-30%NS3 which expresses dengue virus type 4 (DEN4) cDNA encoding NS2B and the N-terminal 184 residues of NS3 from the T7 RNA polymerase promoter. Mutant or wild-type plasmids were transfected into cells which had been infected with a recombinant vaccinia virus expressing T7 RNA polymerase, and the protease activities of the expressed polyproteins were assayed by examining the extent of self-cleavage at the NS2B-NS3 junction. The results identified a 40-amino-acid segment of NS2B (DEN4 amino acids 1396 to 1435) essential for protease activity. A hydrophobicity profile of DEN4 NS2B predicts this segment constitutes a hydrophilic domain surrounded by hydrophobic regions. Hydrophobicity profiles of the NS2B proteins of other flaviviruses show similar patterns. Amino acid sequence alignment of this domain of DEN4 NS2B with comparable regions of other proteins of flaviviruses indicates significant sequence conservation, especially at the N-terminal end. These observations suggest that the central hydrophilic domain of NS2B of these other flaviviruses will also prove to be essential for protease activity.
KW  - amino acids
KW  - arboviruses
KW  - deletions
KW  - enzyme activity
KW  - nucleotide sequences
KW  - proteinases
KW  - viral proteins
KW  - dengue 4 virus
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - DNA sequences
KW  - nonstructural proteins
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant.
AU  - Novembre, F. J.
AU  - Johnson, P. R.
AU  - Lewis, M. G.
AU  - Anderson, D. C.
AU  - Klumpp, S.
AU  - McClure, H. M.
AU  - Hirsch, V. M.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 5
SP  - 2466
EP  - 2474
SN  - 0022-538X
AD  - Novembre, F. J.: (V.M. Hirsch) Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
N1  - Accession Number: 19942051427.  Publication Type: Journal Article.  Language: English. 
KW  - env gene
KW  - molecular biology
KW  - pathogenesis
KW  - pathogenicity
KW  - Macaca
KW  - simian immunodeficiency virus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The RRE of human immunodeficiency virus type 1 contributes to cell-type-specific viral tropism.
AU  - Dayton, E. T.
AU  - Konings, D. A. M.
AU  - Lim, S. Y.
AU  - Hsu, R. K. S.
AU  - Butini, L.
AU  - Pantaleo, G.
AU  - Dayton, A. I.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 5
SP  - 2871
EP  - 2878
SN  - 0022-538X
AD  - Dayton, E. T.: (A.I. Dayton) National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051441.  Publication Type: Journal Article.  Language: English. 
KW  - genomes
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - mutations
KW  - pathogenesis
KW  - Rev protein
KW  - tropisms
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression.
AU  - Kashanchi, F.
AU  - Duvall, J. F.
AU  - Lindholm, P. F.
AU  - Radonovich, M. F.
AU  - Brady, J. N.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 5
SP  - 2894
EP  - 2902
SN  - 0022-538X
AD  - Kashanchi, F.: (J.N. Brady) Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051438.  Publication Type: Journal Article.  Language: English. 
KW  - binding
KW  - gene expression
KW  - molecular biology
KW  - protein
KW  - transcription
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - long terminal repeat
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051438&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice.
AU  - Pletnev, A. G.
AU  - Bray, M.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 8
SP  - 4956
EP  - 4963
SN  - 0022-538X
AD  - Pletnev, A. G.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950507459.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref.
N2  - Two new chimeric flaviviruses were constructed from full-length cDNAs which contained tick-borne encephalitis virus (TBEV) capsid membrane envelope (CME) or membrane envelope (ME) structural protein genes and the remaining genes derived from dengue type 4 virus (DEN4). Studies involving mice inoculated intracerebrally with the ME chimeric virus indicated that it retained the neurovirulence of its TBEV parent from which its pre-M and E genes were derived. However, unlike parental TBEV, the chimeric virus did not produce encephalitis when mice were inoculated peripherally, indicating a loss of neuroinvasiveness. In the present study, the ME chimeric virus (vME) was subjected to mutational analysis in an attempt to reduce or ablate neurovirulence measured by direct inoculation of virus into the brain. 3 distinct mutations were identified each of which was associated independently with a significant reduction of mouse neurovirulence of vME. These mutations ablated (i) the TBEV pre-M cleavage site, (ii) the TBEV E glycosylation site, or (iii) the 1st DEN4 NS1 glycosylation site. In contrast, ablation of the 2nd DEN4 NS1 glycosylation site or the TBE pre-M glycosylation site or amino acid substitution at 2 positions in the TBEV E protein increased neurovirulence. The only conserved feature of the 3 attenuated mutants was restriction of virus yield in both simian and mosquito cells. Following parenteral inoculation, these attenuated mutants induced complete resistance in mice to fatal encephalitis caused by the highly neurovirulent vME.
KW  - arboviruses
KW  - genetics
KW  - laboratory animals
KW  - mutations
KW  - virulence
KW  - chimaera
KW  - dengue 4 virus
KW  - mice
KW  - Tick-borne encephalitis virus
KW  - Chimaeridae
KW  - Chimaeriformes
KW  - Chondrichthyes
KW  - fishes
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - aquatic organisms
KW  - aquatic animals
KW  - eukaryotes
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - arthropod-borne viruses
KW  - Central European encephalitis virus
KW  - glycosylation
KW  - tickborne encephalitis virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507459&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.
AU  - Maldarelli, F.
AU  - Chen, M. Y.
AU  - Willey, R. L.
AU  - Strebel, K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 8
SP  - 5056
EP  - 5061
SN  - 0022-538X
AD  - Maldarelli, F.: Laboratory of Molecular Microbiology, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952009829.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
N2  - The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human immunodeficiency virus. The topology of membrane-inserted Vpu was investigated by using in vitro-synthesized Vpu cotranslationally inserted into canine microsomal membranes. Proteolytic digestion and immunoprecipitation studies revealed that Vpu was a type I integral membrane protein, with the hydrophilic domain projecting from the cytoplasmic membrane face. In addition, several high-molecular-weight proteins containing Vpu were identified by chemical cross-linking. Such complexes also formed when wild-type Vpu and a Tat-Vpu fusion protein were coexpressed. Subsequent analysis by one- and two-dimensional electrophoresis revealed that these high-molecular-weight complexes consisted of homo-oligomers of Vpu. These findings indicate that Vpu is a type I integral membrane protein capable of multimerization.
KW  - human immunodeficiency viruses
KW  - proteins
KW  - surface proteins
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - membrane proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009829&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: Evidence for the involvement of transcription factor Ets1.
AU  - Dittmer, J.
AU  - Gitlin, S. D.
AU  - Reid, R. L.
AU  - Brady, J. N.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 10
SP  - 6087
EP  - 6095
SN  - 0022-538X
AD  - Dittmer, J.: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010516.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref.
N2  - Expression of the parathyroid hormone-related protein (PTHrP), a protein that plays a primary role in the development of the humoral hypercalcaemia of malignancy, is regulated by two distinct promoters, P1 and P2. PTHrP is overexpressed in lymphocytes from adult T-cell leukemia patients. The authors now demonstrate that in the human T-cell lymphotropic virus type I-transformed cell line MT-2, RNA synthesis is initiated primarily at the P2 promoter. Furthermore, in cotransfection experiments, Tax1 transactivates the P2 promoter 10- to 12-fold. By using deletion and site-specific point mutations, the authors have identified a promoter-proximal sequence (positions -72 to -40) which is important for Tax1 transactivation. The PTHrP promoter-proximal element contains two potential overlapping Ets1 binding sites, EBS I and EBS II. Gel shift analysis demonstrated that Ets1 binds specifically to both EBS I and EBS II. Mutation of the consensus GGAA core motif in EBS I abolished binding and Tax1 transactivation in Jurkat T lymphocytes. In Ets1-deficient cells, cotransfection of Tax1 and Ets1 expression plasmids stimulates PTHrP promoter activity. In the absence of Ets1, minimal transactivation of the PTHrP promoter is observed. These data suggest that Ets1 binds to EBS I and cooperates with Tax1 to transactivate the PTHrP P2 promoter.
KW  - infections
KW  - parathyroid
KW  - promoters
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - HTLV-BLV group
KW  - parathyroid gland
KW  - promoter region
KW  - promoter sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010516&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.
AU  - Jeang, K. T.
AU  - Chun, R.
AU  - Lin, N. H.
AU  - Gatignol, A.
AU  - Glabe, C. G.
AU  - Fan, H.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 10
SP  - 6224
EP  - 6233
SN  - 0022-538X
AD  - Jeang, K. T.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010520.  Publication Type: Journal Article.  Language: English.  Number of References: 75 ref.
N2  - Recent genetic experiments have suggested that tat transactivation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat requires functional upstream enhancer sequences-Sp1 sites, in particular. In these experiments, HeLa cell nuclear extracts were passed over affinity matrices containing chemically synthesized or bacterially expressed HIV-1 Tat. Assay of material that bound to and eluted from the Tat matrices revealed the presence of the Sp1 transcription factor. Other transcription factors (Oct and NF-κB) also bound to Tat matrices but with less efficiency - in parallel with the lower capacities of these binding motifs to confer Tat responsiveness on a basal HIV-1 promoter compared with Sp1 sites. Passage of nuclear extracts over matrices containing other neutral proteins, including bovine serum albumin, ovalbumin, and lysozyme, revealed no or reduced binding. Cross-linking experiments indicated that the purified Sp1 and Tat proteins can form multimeric complexes in the absence of other proteins. The region of Tat responsible for Sp1 binding was localized to a region encompassing residues 30 to 62. Immunoprecipitation experiments with HIV-1-infected T lymphocytes indicated coimmunoprecipitation of Tat and Sp1. These experiments extend previous genetic experiments and suggest a direct interaction between Tat and Sp1 during transactivation.
KW  - in vitro
KW  - infections
KW  - proteins
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA transcription
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010520&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.
AU  - Purcell, D. F. J.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 11
SP  - 6365
EP  - 6378
SN  - 0022-538X
AD  - Purcell, D. F. J.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952009967.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref.
KW  - human immunodeficiency viruses
KW  - infectivity
KW  - messenger rna
KW  - proteins
KW  - replication
KW  - viral diseases
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - mRNA
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009967&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic determinants of dengue type 4 virus neurovirulence for mice.
AU  - Kawano, H.
AU  - Rostapshov, V.
AU  - Rosen, L.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 11
SP  - 6567
EP  - 6575
SN  - 0022-538X
AD  - Kawano, H.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950507462.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
N2  - Mouse-adapted dengue type 4 virus (DEN4) strain H241 is highly neurovirulent for mice, whereas its non-mouse-adapted parent is rarely neurovirulent. The genetic basis for the neurovirulence of the mouse-adapted mutant was studied by comparing intratypic chimeric viruses which contained the 3 structural protein genes from the parental virus or the neurovirulent mutant in the background sequence of nonneurovirulent DEN4 strain 814669. The chimera which contained the 3 structural protein genes from mouse neurovirulent DEN4 strain H241 proved to be highly neurovirulent in mice, whereas the chimera which contained the corresponding genes from its non-mouse-adapted parent was not neurovirulent. This finding indicates that most of the genetic loci for the neurovirulence of the DEN4 mutant lie within the structural protein genes. A comparison of the amino acid sequences of the parent and its mouse neurovirulent mutant proteins revealed that there were only 5 amino acid differences in the structural protein region, and 3 of these were located in the envelope (E) glycoprotein. Analysis of chimeras which contained 1 or 2 of the variant amino acids of the mutant E sequence substituting for the corresponding sequence of the parental virus identified 2 of these amino acid changes as important determinants of mouse neurovirulence. First, the single substitution of Ile for Thr-155 which ablated 1 of the 2 conserved glycosylation sites in parental E yielded a virus which was almost as neurovirulent as the mouse-adapted mutant. Thus, the loss of an E glycosylation site appears to play a role in DEN4 neurovirulence. Second, the substitution of Leu for Phe-401 also yielded a neurovirulent virus, but it was less neurovirulent than the glycosylation mutant. These findings indicate that at least 2 of the genetic loci responsible for DEN4 mouse neurovirulence map within the structural protein genes.
KW  - amino acid sequences
KW  - amino acids
KW  - arboviruses
KW  - genetics
KW  - laboratory animals
KW  - virulence
KW  - dengue 4 virus
KW  - mice
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.
AU  - Li, G.
AU  - Lisziewicz, J.
AU  - Sun, D.
AU  - Zon, G.
AU  - Daefler, S.
AU  - Wong-Staal, F.
AU  - Gallo, R. C.
AU  - Klotman, M. E.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1993///
VL  - 67
IS  - 11
SP  - 6882
EP  - 6888
SN  - 0022-538X
AD  - Li, G.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952009974.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref.
N2  - The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. The authors demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.
KW  - analogues
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - replication
KW  - rev protein
KW  - viral diseases
KW  - viral regulatory proteins
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009974&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiology of epilepsy in developing countries.
AU  - Senanayake, N.
AU  - Román, G. C.
JO  - Bulletin of the World Health Organization
JF  - Bulletin of the World Health Organization
Y1  - 1993///
VL  - 71
IS  - 2
SP  - 247
EP  - 258
SN  - 0042-9686
AD  - Senanayake, N.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940800920.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Number of References: 93 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - This article reviews the epidemiology of epilepsy in developing countries in terms of its incidence, prevalence, seizure type, mortality data, and aetiology. The prevalence of epilepsy is particularly high in Latin America, Liberia, Nigeria and Tanzania. Parasitic infections, particularly neurocysticercosis, are important aetiological factors in the pathogenesis of epilepsy in many of these countries. Other factors include intracranial infections, perinatal brain damage, head injuries, and toxic agents.
KW  - brain
KW  - epidemiology
KW  - epilepsy
KW  - geographical distribution
KW  - helminths
KW  - human diseases
KW  - metacestodes
KW  - neurocysticercosis
KW  - parasites
KW  - reviews
KW  - Developing countries
KW  - Cestoda
KW  - man
KW  - Taenia solium
KW  - Taeniidae
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - countries
KW  - cerebrum
KW  - parasitic worms
KW  - pork tapeworm
KW  - prevalence
KW  - Third World
KW  - Underdeveloped Countries
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800920&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of the murine model of schistosomal hepatic periportal fibrosis ("pipestem" fibrosis).
AU  - Andrade, Z. A.
AU  - Cheever, A. W.
JO  - International Journal of Experimental Pathology
JF  - International Journal of Experimental Pathology
Y1  - 1993///
VL  - 74
IS  - 2
SP  - 195
EP  - 202
SN  - 0959-9673
AD  - Andrade, Z. A.: (A.W. Cheever) Laboratory of Parasitic Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020954.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of normal-looking hepatic parenchyma, a picture mimicking 'clay pipestem fibrosis' seen in human patients with advanced schistosomiasis. The model was reproduced in outbred and in several strains of inbred mice, and their main characteristics were studied and compared to the human counterpart. A balanced consideration of the similarities and differences between the murine model and human pipestem fibrosis is needed for the adequate utilization of this simple, reproducible and inexpensive experimental model. AS
KW  - Schistosomiasis
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bilharzia
KW  - bilharziasis
KW  - hepatic periportal fibrosis
KW  - schistosomosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020954&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro culture of the mosquito stages of Plasmodium falciparum.
AU  - Warburg, A.
AU  - Schneider, I.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1993///
VL  - 76
IS  - 2
SP  - 121
EP  - 126
SN  - 0014-4894
AD  - Warburg, A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804184.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2  - The sporogonic cycle of P. falciparum was obtained in vitro. Mature gametocytes, from blood-stage cultures, produced gametes that underwent fertilization at elevated pH and ambient temperatures. Wheat germ agglutinin stimulated transformation of zygotes into retorts and ookinetes. 24 h thereafter, 18-49% mature ookinetes and 10-20% intermediate retort forms were counted. Cultures were seeded onto a basement membrane-like gel (Matrigel) in coculture with Drosophila melanogaster cells. Both ookinetes and retorts attached to Matrigel and transformed into oocysts. Mature oocysts and sporozoites expressed circumsporozoite protein.\From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The sporogonic cycle of P. falciparum was obtained in vitro. Mature gametocytes, from blood-stage cultures, produced gametes that underwent fertilization at elevated pH and ambient temperatures. Wheat germ agglutinin stimulated transformation of zygotes into retorts and ookinetes. 24 h thereafter, 18-49% mature ookinetes and 10-20% intermediate retort forms were counted. Cultures were seeded onto a basement membrane-like gel (Matrigel) in coculture with Drosophila melanogaster cells. Both ookinetes and retorts attached to Matrigel and transformed into oocysts. Mature oocysts and sporozoites expressed circumsporozoite protein.
KW  - culture techniques
KW  - Developmental stages
KW  - Human diseases
KW  - malaria
KW  - Oocysts
KW  - Ookinetes
KW  - parasites
KW  - sporogony
KW  - Anopheles
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - falciparum malaria
KW  - growth phase
KW  - mosquito stages
KW  - mosquitoes
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Normal dexamethasone suppression in obese binge and nonbinge eaters with rapid weight loss.
AU  - Yanovski, S. Z.
AU  - Yanovski, J. A.
AU  - Gwirtsman, H. E.
AU  - Bernat, A.
AU  - Gold, P. W.
AU  - Chrousos, G. P.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1993///
VL  - 76
IS  - 3
SP  - 675
EP  - 679
SN  - 0021-972X
AD  - Yanovski, S. Z.: Clinical Neuroendocrinology Branch, National Institutes of Health, Building 10, 3S231, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941403813.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 1879-72-7, 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1, 1926-94-9, 2265-67-7, 312-93-6, 50-02-2, 55812-90-3, 7743-96-6, 2392-39-4, 16978-57-7.  Subject Subsets: Human Nutrition
N2  - To evaluate whether rapid weight loss per se or some other aspect of starvation induces disruption of the hypothalamic-pituitary-adrenal (HPA) axis, 2 categories of obese women (body mass index &gt;30 kg/m2) undergoing rapid weight loss were investigated: bulimics (n=12) and nonbinge eaters (n=8). Psychometric evaluation and overnight dexamethasone (1 mg) suppression tests were performed in obese as well as 12 race- and age-matched normal-weight women. Obese women were tested before and after 12 weeks of a liquid formula diet (800 kcal/day) and lost an average of 19.3 kg, which represented 17.3% of total body weight. Bulimics who were initially more depressed than nonbinge eaters or normal-weight controls, had a significant amelioration of their symptoms with weight loss. Neither group had evidence of disruption of the HPA axis before or after weight loss. Thus, rate of failure to suppress cortisol after dexamethasone was about 10% in obese and control groups and did not differ between pre- and postweight loss condition or between binge and nonbinge eaters. Serum free thyroxine was unchanged, whereas triiodothyronine decreased significantly with weight loss. It is concluded that weight loss may improve affect in the obese without altering HPA axis activity and it is suggested that one of the concomitants of restricted energy intake, perhaps in combination with a threshold body weight, may be of greater importance in causing abnormalities of dexamethasone suppression testing than rapid weight loss per se.
KW  - appetite disorders
KW  - bulimia
KW  - dexamethasone
KW  - hydrocortisone
KW  - obesity
KW  - weight reduction
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - binge eating
KW  - bulimia nervosa
KW  - cortisol
KW  - eating disorders
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403813&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Absence of triglyceride accumulation in lipoprotein lipase-deficient human monocyte-macrophages incubated with human very low density lipoprotein.
AU  - Skarlatos, S. I.
AU  - Dichek, H. L.
AU  - Fojo, S. S.
AU  - Brewer, H. B.
AU  - Kruth, H. S.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1993///
VL  - 76
IS  - 3
SP  - 793
EP  - 796
SN  - 0021-972X
AD  - Skarlatos, S. I.: Section of Experimental Atherosclerosis, Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941403814.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 57-88-5, 9004-02-8.  Subject Subsets: Human Nutrition
N2  - The role of lipoprotein lipase in mediating uptake of normal VLDL triacylglycerols into human cultured monocyte-derived macrophages was studied using macrophage cells from a functionally lipoprotein lipase-deficient patient (a 36-years-old woman) and macrophages of cells from a normal subject (a 25-years-old man). After incubation with VLDL, massive accumulation of phase refractile (lipid) inclusions were noted by phase contrast microscopy within the normal, but not within the lipoprotein lipase-deficient macrophages. Chemical determinations of intracellular lipid confirmed massive triacylglycerol accumulation within normal but not in lipoprotein lipase-deficient macrophages. VLDL-derived cholesterol did not accumulate in either cell. Results confirm an additional role of lipoprotein lipase, that of mediating triacylglycerol accumulation into macrophages from normal human VLDL. Human monocyte-macrophages genetically deficient in a functional lipoprotein lipase will be useful to evaluate the role of lipoprotein lipase in macrophage accumulation of lipid from other forms of triacylglycerol-carrying lipoproteins, including hypertriglyceridaemic VLDL, β-VLDL and chylomicrons.
KW  - cell cultures
KW  - cholesterol
KW  - deficiency
KW  - lipoprotein lipase
KW  - macrophages
KW  - triacylglycerols
KW  - very low density lipoprotein
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - diacylglycerol lipase
KW  - triglycerides
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403814&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmania: immunochemical comparison of the secretory (extracellular) acid phosphatases from various species.
AU  - Doyle, P. S.
AU  - Dwyer, D. M.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1993///
VL  - 77
IS  - 4
SP  - 435
EP  - 444
SN  - 0014-4894
AD  - Doyle, P. S.: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940801369.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9001-77-8.  Subject Subsets: Protozoology; Tropical Diseases
N2  - The soluble acid phosphatases (SAcP(s)) from various Leishmania species were compared immunochemically using both a monospecific rabbit antiserum and several MAbs made against the purified promastigotes SAcP of a cloned line of Leishmania donovani donovani. Results obtained from antibody-bridged enzyme activity assays demonstrated that these reagents quantitatively immunoprecipitated the enzymatic activities of SAcP(s) from 18 different W.H.O. reference stocks of Leishmania, including 2 L. major strains. These results showed, for the first time, that all SAcP(s) possessed some common cross-reactive antigenic epitopes. Immunoprecipitates obtained from [35S]methionine, metabolically labelled promastigote culture supernatants of the various species, were analyzed by SDS-PAGE/fluorography. These analyses showed that marked differences existed among the SAcP(s) both in their relative mobilities and the number of constituent bands resolved. Tunicamycin treatment resulted in a significant reduction in the apparent MWs of SAcP(s) from 3 different isolates, confirming the presence of N-linked carbohydrate side chains in these enzymes. In addition, the SAcP released by L. donovani intracellular amastigotes was also immunoprecipitated with the monospecific rabbit antisera from the culture supernatant of infected macrophages. It is concluded that despite individual species variations, the SacP(s) from all Leishmania tested have retained certain common antigenic/structural epitopes and functional protein domains. Such conservation among SAcP(s) suggests that this enzyme must play an essential role in the survival of promastigotes and amastigotes of all Leishmania species.
KW  - acid phosphatase
KW  - antigens
KW  - biochemistry
KW  - enzymes
KW  - epitopes
KW  - human diseases
KW  - immunochemistry
KW  - parasites
KW  - Leishmania
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - acid phosphatases
KW  - acid phosphomonoesterase
KW  - antigenic determinants
KW  - antigenicity
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801369&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Entamoeba histolytica: a method for isolate identification.
AU  - Clark, C. G.
AU  - Diamond, L. S.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1993///
VL  - 77
IS  - 4
SP  - 450
EP  - 455
SN  - 0014-4894
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940801371.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A method to identify individual isolates of Entamoeba histolytica was developed, based on the discovery of extensive polymorphism in 2 Ent. histolytica genes, the serine-rich antigen gene and the "strain specific gene", each of which has an internal tandemly repeated structure. Using the polymerase chain reaction both size and restriction site polymorphisms were detected in the repetitive regions. When the 2 genes were used in combination 16 distinct DNA patterns were obtained out of 18 isolates examined. Moreover, these patterns were stable under a variety of conditions: long-term culture, axenization, cell cloning, and animal passage.From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A method to identify individual isolates of Entamoeba histolytica was developed, based on the discovery of extensive polymorphism in 2 E. histolytica genes, the serine-rich antigen gene and the "strain specific gene", each of which has an internal tandemly repeated structure. Using the polymerase chain reaction both size and restriction site polymorphisms were detected in the repetitive regions. When the 2 genes were used in combination 16 distinct DNA patterns were obtained out of 18 isolates examined. Moreover, these patterns were stable under a variety of conditions: long-term culture, axenization, cell cloning, and animal passage.
KW  - chemotaxonomy
KW  - genes
KW  - human diseases
KW  - Identification
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - techniques
KW  - Endamoebidae
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Endamoebidae
KW  - biochemical genetics
KW  - biochemical taxonomy
KW  - Isolates
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Techniques and Methodology (ZZ900) 
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Entamoeba histolytica: an explanation for the reported conversion of "nonpathogenic" amebae to the "pathogenic" form.
AU  - Clark, C. G.
AU  - Diamond, L. S.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1993///
VL  - 77
IS  - 4
SP  - 456
EP  - 460
SN  - 0014-4894
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940801372.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The reported conversion of "nonpathogenic" Entamoeba histolytica isolates to the "pathogenic" form during attempted axenization of the amoebae was investigated with regard to the possibility of contamination of nonpathogenic cultures with pathogenic amoebae. To investigate this possibility a method was used based on analysis of stable DNA polymorphisms that allows the positive identification of individual pathogenic isolates. The DNA patterns obtained using the "converted" amoebae proved to be identical to those of reference isolates present in the laboratories at the time of conversion. It was also found that very few cells needed to be transferred for a pathogenic contaminant to become established in a nonpathogenic culture. It is concluded that cross-contamination fully explains the conversion phenomenon and thus recognition of nonpathogenic and pathogenic amebae as the distinct species Ent. dispar and Ent. histolytica, respectively, is upheld.From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;The reported conversion of "nonpathogenic" Entamoeba histolytica isolates to the "pathogenic" form during attempted axenization of the amoebae was investigated with regard to the possibility of contamination of nonpathogenic cultures with pathogenic amoebae. To investigate this possibility a method was used based on analysis of stable DNA polymorphisms that allows the positive identification of individual pathogenic isolates. The DNA patterns obtained using the "converted" amoebae proved to be identical to those of reference isolates present in the laboratories at the time of conversion. It was also found that very few cells needed to be transferred for a pathogenic contaminant to become established in a nonpathogenic culture. It is concluded that cross-contamination fully explains the conversion phenomenon and thus recognition of nonpathogenic and pathogenic amebae as the distinct species E. dispar and E. histolytica, respectively, is upheld.
KW  - conversion
KW  - human diseases
KW  - parasites
KW  - Pathogenicity
KW  - Endamoebidae
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Endamoebidae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801372&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diet as risk and therapy for cancer.
AU  - Clifford, C.
AU  - Kramer, B.
JO  - Medical Clinics of North America
JF  - Medical Clinics of North America
Y1  - 1993///
VL  - 77
IS  - 4
SP  - 725
EP  - 744
SN  - 0025-7125
AD  - Clifford, C.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19941401093.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition
N2  - A brief overview of the scientific rationale for dietary guidelines that may reduce the risk of some types of cancers, breast, colon, and prostate in particular, is presented. Dietary modification clinical trials currently sponsored by the National Cancer Institute (USA) are described. Other topics include the role of total parenteral nutrition in cancer therapy and low-fat dietary interventions as an adjunct to breast cancer treatment.
KW  - carcinoma
KW  - colon
KW  - diet
KW  - diet treatment
KW  - mammary gland neoplasms
KW  - parenteral feeding
KW  - prostate
KW  - reviews
KW  - risk
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - diet prescription
KW  - mammary tumour
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intraspecific diversity in the response of Trypanosoma cruzi to environmental stress.
AU  - Nozaki, T.
AU  - Dvorak, J. A.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1993///
VL  - 79
IS  - 3
SP  - 451
EP  - 454
SN  - 0022-3395
AD  - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 138, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806350.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology
N2  - Epimastigotes of 5 Trypanosoma cruzi stocks were cultivated in liver infusion tryptose (LIT) medium at 23-25°C or cocultivated with vertebrate cells at 35°C. A temperature decrease from 26 to 23°C resulted in a stable 60% increase in population doubling time. In zymodeme I and II stocks, a temperature increase to 35°C resulted in a transient ~25% increase in doubling time during the first month followed by a ~30% decrease after 2 months. A zymodeme III stock did not grow at 35°C. Flow cytometric analyses showed that the total DNA/cell, guanine + cytosine (G-C), and adenine + thymidine content of 2 zymodeme II stocks increased by 3-11% when cultivated in LIT at 35°C, whereas the DNA values of 2 zymodeme I stocks did not change. The increased DNA levels, due predominantly to an increased kinetoplast G-C content, returned to normal levels when the culture temperature was reduced to 26°C. The effects of cocultivation with vertebrate cells at 35°C were identical to cultivation in LIT at 35°C except that the DNA increase in a zymodeme II stock was not stable. Total DNA/cell, nuclear, and kinetoplast DNA decreased by 8-13% upon prolonged cocultivation. No change in total protein, antigen profiles, complement sensitivity, or heat shock protein gene expression was observed as a consequence of culturing the parasites above 26°C.
KW  - chemotaxonomy
KW  - Culture techniques
KW  - DNA
KW  - heat shock
KW  - Heat stress
KW  - Human diseases
KW  - molecular genetics
KW  - parasites
KW  - Physiology
KW  - Temperature
KW  - Zymodemes
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - biochemical genetics
KW  - biochemical taxonomy
KW  - deoxyribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular biology studies of tubercidin resistance in Trypanosoma cruzi.
AU  - Nozaki, T.
AU  - Dvorak, J. A.
JO  - Parasitology Research
JF  - Parasitology Research
Y1  - 1993///
VL  - 79
IS  - 6
SP  - 451
EP  - 455
SN  - 0044-3255
AD  - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940800270.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A Trypanosoma cruzi stock (Sylvio-X10/7) was mutagenized and selected for resistance to high levels of tubercidin (TUB), a purine analogue. The TUB-resistant stocks were &gt;100 times more resistant to TUB than was the parental stock. TUB and uridine transport in the TUB-resistant stocks decreased by 50%-90%, whereas thymidine and adenosine transport were unaffected. The data imply that TUB-resistant stocks have defects in the pathways involved in the transport of TUB and uridine but not in the thymidine and adenosine transport pathways. Karyotype analyses using specific probes showed that the deletion of a 950-kb chromosome-size DNA occurred in both of the TUB-resistant stocks. The data suggest that genes involved in nucleoside transport are located in this DNA region.From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;A Trypanosoma cruzi stock (Sylvio-X10/7) was mutagenized and selected for resistance to high levels of tubercidin (TUB), a purine analogue. The TUB-resistant stocks were &gt;100 times more resistant to TUB than was the parental stock. TUB and uridine transport in the TUB-resistant stocks decreased by 50%-90%, whereas thymidine and adenosine transport were unaffected. The data imply that TUB-resistant stocks have defects in the pathways involved in the transport of TUB and uridine but not in the thymidine and adenosine transport pathways. Karyotype analyses using specific probes showed that the deletion of a 950-kb chromosome-size DNA occurred in both of the TUB-resistant stocks. The data suggest that genes involved in nucleoside transport are located in this DNA region.
KW  - biochemistry
KW  - human diseases
KW  - Molecular biology
KW  - nucleosides
KW  - parasites
KW  - purines
KW  - Resistance
KW  - uptake
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - purine bases
KW  - tubercidin
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The risk of measles, mumps, and varicella among young adults: a serosurvey of US Navy and Marine Corps recruits.
AU  - Struewing, J. P.
AU  - Hyams, K. C.
AU  - Tueller, J. E.
AU  - Gray, G. C.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993///
VL  - 83
IS  - 12
SP  - 1717
EP  - 1720
SN  - 0090-0036
AD  - Struewing, J. P.: National Institutes of Health, Genetic Epidemiology Branch, Bldg EPN-439, Bethesda, MD 20892-9903, USA.
N1  - Accession Number: 19942050298.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - To assess the risk of epidemic transmission and to guide immunization policy, the seroprevalence of antibody to measles, mumps, and varicella was determined in a group of young adults. A cross-sectional study of 1533 US Navy and Marine Corps recruits was conducted in June 1989. Antibody status was determined with commercially available enzyme-linked immunosorbent assays. Direct sex and race adjustment to the 15- to 29-year-old US population resulted in seronegativity rates of 17.8% for measles, 12.3% for mumps, and 6.7% for varicella. Measles and mumps seronegativity rates were higher among Whites whereas varicella seronegativity was higher among non-Whites. Recruits enlisting from outside the 50 US states, especially those from island territories, were more likely to lack varicella antibody. The sensitivity of a positive history of vaccination or disease in predicting antibody status was less than 90% for all diseases. These results suggested a continued potential for epidemics, especially of measles, and the need for mandatory immunization policies. Immigrants to the United States, especially those from island territories, may be a high-risk group that could benefit from varicella vaccination. AS
KW  - antibodies
KW  - Measles
KW  - military personnel
KW  - Mumps
KW  - Varicella
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - chicken pox
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer in the elderly: meeting the challenge of an aging population.
AU  - Monfardini, S.
AU  - Yancik, R.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 7
SP  - 532
EP  - 538
SN  - 0027-8874
AD  - Monfardini, S.: (R. Yancik) National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg. 31, Rm. 5C05, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942027667.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Public Health
N2  - This commentary focuses on cancer in the elderly, particularly in the United States and Italy. Cancer incidence, cancer mortality, aging of the population, slow accumulation of treatment information, and future research on aging and cancer are discussed.
KW  - elderly
KW  - Neoplasms
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - aged
KW  - cancers
KW  - elderly people
KW  - older adults
KW  - senior citizens
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027667&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women.
AU  - Reichman, M. E.
AU  - Judd, J. T.
AU  - Longcope, C.
AU  - Schatzkin, A.
AU  - Clevidence, B. A.
AU  - Nair, P. P.
AU  - Campbell, W. S.
AU  - Taylor, P. R.
AU  - Longnecker, M. P.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 9
SP  - 722
EP  - 727
SN  - 0027-8874
AD  - Reichman, M. E.: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19941409493.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Registry Number: 64-17-5.  Subject Subsets: Human Nutrition; Public Health
N2  - A study was examined to investigate the hypothesis that alcohol consumption affects values of reproductive hormones. 34 premenopausal women 21-40 years old were studied for 6 consecutive menstrual cycles and consumed ethanol 30 g (equivalent to about 2 average drinks) daily for 3 menstrual cycles and then no alcohol for the next 3 months. Energy intake was monitored to ensure that each woman would maintain body weight at about baseline level. Hormone assays were performed on pooled plasma or 24-h urine collected during follicular days (days 5-7), peri-ovulatory (days 12-15) and mid-luteal (days 21-23) phases of the third menstrual cycle for subjects on each diet. Results showed that alcohol consumption was was associated with significant increases in values of several hormones. Plasma dehydroepiandrosterone sulfate values were 7.0% higher in the follicular phase (P=0.05). In the peri-ovulatory phase, there were increases of 21.2% (P=0.01) in plasma estrone values, 27.5% (P=0.01) in plasma estradiol and 31.9% (P=0.009) in urinary estradiol values. In the luteal phase, urinary estrone values increased 15.2% (P=0.05), estradiol 21.6% (P=0.02) and estriol 29.1% (P=0.03). No changes were found in the percent of bioavailable estradiol, defined by the sum of percent free estradiol and percent albumin-bound estradiol. Increased total estradiol values in the peri-ovulatory phase suggest elevated absolute amounts of bioavailable estradiol. Increases in total estrogen values and amount of available estrogens in association with ethanol consumption in premenopausal women was shown.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;In this study of 34 premenopausal women aged 21-40 years [in Maryland, USA], the authors examine the hypothesis that alcohol consumption affects levels of reproductive hormones-a possible explanatory mechanism for a positive association between alcohol consumption and breast cancer risk. The study showed increases in total oestrogen levels and amount of bioavailable oestrogens in association with alcohol. The authors conclude that these results merit further investigation. M.P. Longnecker discusses the hormonal link between alcohol and breast cancer in an editorial on p692 of this issue. Louise M. Acres
KW  - alcohol intake
KW  - alcoholic beverages
KW  - blood
KW  - breast
KW  - breast cancer
KW  - ethanol
KW  - intake
KW  - menstrual cycle
KW  - neoplasms
KW  - oestrogens
KW  - risk
KW  - urine
KW  - women
KW  - Maryland
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - alcohol consumption
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - estrogens
KW  - ethyl alcohol
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Women (UU500) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409493&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia.
AU  - Schiffman, M. H.
AU  - Bauer, H. M.
AU  - et al.
AU  - Hoover, R. N. (
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 12
SP  - 958
EP  - 964
SN  - 0027-8874
AD  - Schiffman, M. H.: National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942027740.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors studied 500 women with cervical intraepithelial neoplasia (CIN) and 500 control subjects receiving cytologic screening at Kaiser Permanente, a large prepaid health plan, in Portland, Oregon, USA. The established epidemiologic risk factors for CIN were assessed by telephone interview. They performed HPV testing of cervicovaginal lavage specimens by gene amplification using polymerase chain reaction with a consensus primer to target the L1 gene region of HPV. Unconditional logistic regression analysis was used to estimate relative risk of CIN and to adjust the epidemiologic associations for HPV test results to demonstrate whether the associations were mediated by HPV. The case subjects demonstrated the typical epidemiologic profile of CIN: they had more sex partners, more cigarette smoking, earlier ages at first sexual intercourse, and lower socioeconomic status. Statistical adjustment for HPV infection substantially reduced the size of each of these case-control differences. Seventy-six percent of cases could be attributed to HPV infection; the results of cytologic review suggested that the true percentage was even higher. Once HPV infection was taken into account, an association of parity with risk of CIN was observed in both HPV-negative and HPV-positive women. The data show that the great majority of all grades of CIN can be attributed to HPV infection, particularly with the cancer-associated types of HPV. In light of this conclusion, the investigation of the natural history of HPV has preventive as well as etiologic importance. [In an editorial on p 934 of this issue N.B. Kiviat and L.A. Koulsky discuss the implications for current views and treatment.]From AS
KW  - cervical cancer
KW  - cervix
KW  - epidemiology
KW  - infections
KW  - neoplasms
KW  - North America
KW  - Oregon
KW  - USA
KW  - human papillomaviruses
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - America
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - Papillomaviridae
KW  - cancer sites
KW  - cancers
KW  - human papillomavirus
KW  - Papovaviridae
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027740&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mortality from second tumors among long-term survivors of retinoblastoma.
AU  - Eng, C.
AU  - Li, F. P.
AU  - et al.
AU  - Abramson, D. H. (
AU  - Boice, J. D. Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 14
SP  - 1121
EP  - 1128
SN  - 0027-8874
AD  - Eng, C.: (J.D. Boice, Jr) Radiation Epidemiology Branch, National Cancer Institute, EPN 408, 6130 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19942027282.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - "A retrospective cohort study examined mortality among 1603 patients enrolled at 1 year after diagnosis of retinoblastoma during the period 1914-1984."
KW  - children
KW  - eyes
KW  - mortality
KW  - neoplasms
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - second tumours
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027282&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population.
AU  - Blot, W. J.
AU  - Li, J. Y.
AU  - et al.
AU  - Taylor, P. R. (
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 18
SP  - 1483
EP  - 1492
SN  - 0027-8874
AD  - Blot, W. J.: Biostatistics Branch, Division of Cancer Etiology, National Cancer Institute, 6130 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19942027313.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health; Tropical Diseases
N2  - Individuals of ages 40-69 were recruited in 1985 from four Linxian communes in China. Mortality and cancer incidence during March 1986-May 1991 were ascertained for 29 584 adults who received daily vitamin and mineral supplementation throughout this period. The subjects were randomly assigned to intervention groups according to a one-half replicate of a 24 factorial experimental design. This design enabled testing for the effects of four combinations of nutrients: (A) retinol and zinc; (B) riboflavin and niacin; (C) vitamin C and molybdenum; and (D) beta carotene, vitamin E, and selenium. Doses ranged from one to two times US Recommended Daily Allowances. A total of 2127 deaths occurred among trial participants during the intervention period. Cancer was the leading cause of death, with 32% of all deaths due to oesophageal or stomach cancer, followed by cerebrovascular disease (25%). Significantly (P = 0.03) lower total mortality (relative risk [RR] = 0.91; 95% confidence interval [CI] = 0.84-0.99) occurred among those receiving supplementation with beta carotene, vitamin E, and selenium. The reduction was mainly due to lower cancer rates (RR = 0.87; 95% CI = 0.75-1.00), especially stomach cancer (RR = 0.79; 95% CI = 0.64-0.99), with the reduced risk beginning to arise about 1-2 years after the start of supplementation with these vitamins and minerals. No significant effects on mortality rates from all causes were found for supplementation with retinol and zinc, riboflavin and niacin, or vitamin C and molybdenum. Patterns of cancer incidence, on the basis of 1298 cases, generally resembled those for cancer mortality. The authors' findings indicate that vitamin and mineral supplementation of the diet of Linxian adults, particularly with the combination of beta carotene, vitamin E, and selenium, may effect a reduction in cancer risk in this population. From AS
KW  - epidemiology
KW  - neoplasms
KW  - oesophagus
KW  - stomach
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - esophagus
KW  - nutrition intervention
KW  - People's Republic of China
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia.
AU  - Li, J. Y.
AU  - Taylor, P. R.
AU  - et al.
AU  - Li, B. (
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 18
SP  - 1492
EP  - 1498
SN  - 0027-8874
AD  - Li, J. Y.: Biostatics Branch, Division of Cancer Etiology, National Cancer Institute, 6130 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19942027314.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health; Tropical Diseases
N2  - To determine whether supplementation with multiple vitamins and minerals may reduce oesophageal/gastric cardia cancer among persons in Linxian, China, with oesophageal dysplasia, the authors conducted a 6-year prospective intervention trial in Linxian. Mortality and cancer incidence were ascertained from May 1985 through May 1991 for 3318 persons with cytologic evidence of oesophageal dysplasia who were randomly assigned to receive, throughout that period, daily supplementation with 14 vitamins and 12 minerals or placebo. Doses were typically 2-3 times US Recommended Daily Allowances. Compliance was assessed by counting unused pills monthly for all trial participants and by assaying nutrient levels in blood collected from samples of individuals randomly selected without replacement every 3 months throughout the trial. Cancers were identified through routine surveillance and by special cytology and endoscopy screenings after 21/2 years and 6 years. A total of 324 deaths occurred during the 6-year intervention period; 167 occurred in the control (placebo) group and 157 occurred in the supplement group. Cancer was the leading cause of death (54% of all deaths); 18% were due to cerebrovascular diseases and 29% to other causes. Cumulative oesophageal/gastric cardia death rates were 8% lower (relative risk [RR] = 0.92; 95% confidence interval [CI] = 0.67-1.28) among individuals receiving supplements rather than placebo, a non-significant (P &gt;0.10) difference. Risk of total mortality was 7% lower (RR = 0.93; 95% CI = 0.75-1.16; P &gt;0.10), total cancer 4% lower (RR = 0.96; 95% CI = 0.71-1.29; P &gt;0.10), cerebrovascular disease 38% lower (RR = 0.62; 95% CI = 0.37-1.06; P = 0.08), and other diseases 12% higher (RR = 1.12; 95% CI = 0.74-1.69; P &gt;0.10) among the treated group. Cumulative cancer incidence rates were nearly the same in the two groups. The authors conclude that no substantial short-term beneficial effect on incidence or mortality for this type of cancer occurred following daily supplementation with multiple vitamins and minerals among adults with precancerous lesions of the oesophagus. Longer follow-up should be more informative about the effectiveness of this 6-year supplementation on cancer and other diseases among individuals with oesophageal dysplasia. From AS
KW  - epidemiology
KW  - neoplasms
KW  - oesophagus
KW  - stomach
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - esophagus
KW  - nutrition intervention
KW  - People's Republic of China
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Migration patterns and breast cancer risk in Asian-American women.
AU  - Ziegler, R. G.
AU  - Hoover, R. N.
AU  - et al.
AU  - Pike, M. C. (
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 22
SP  - 1819
EP  - 1827
SN  - 0027-8874
AD  - Ziegler, R. G.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028026.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health; Tropical Diseases
N2  - A population-based, case-control study of breast cancer among women of Chinese, Japanese, and Filipino ethnicities, aged 20-55 years, was conducted during 1983-1987 in San Francisco-Oakland, California, Los Angeles, California, and Oahu, Hawaii. The authors successfully interviewed 597 case subjects (70% of those eligible) and 966 control subjects (75%). A six-fold gradient in breast cancer risk by migration patterns was observed. Asian-American women born in the West had a breast cancer risk 60% higher than Asian-American women born in the East. Among those born in the West, risk was determined by whether their grandparents, especially grandmothers, were born in the East or the West. Asian-American women with three or four grandparents born in the West had a risk 50% higher than those with all grandparents born in the East. Among the Asian-American women born in the East, breast cancer risk was determined by whether their communities prior to migration were rural or urban and by the number of years subsequently lived in the West. Ethnic-specific incidence rates of breast cancer in the migrating generation were clearly elevated above those in the countries of origin, while rates in Asian-Americans born in the West approximated the US White rate. The authors conclude that exposure to Western lifestyles had a substantial impact on breast cancer risk in Asian migrants to the United States during their lifetime. There was no direct evidence of an especially susceptible period, during either menarche or early reproductive life. Because heterogeneity in breast cancer risk in these ethnic populations is similar to that in international comparisons and because analytic epidemiologic studies offer the opportunity to disentangle correlated exposures, this study should provide new insights into the aetiology of breast cancer. From AS
KW  - Asians
KW  - breast
KW  - breast cancer
KW  - epidemiology
KW  - neoplasms
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Saturated fat intake and lung cancer risk among nonsmoking women in Missouri.
AU  - Alavanja, M. C. R.
AU  - Brown, C. C.
AU  - Swanson, C.
AU  - Brownson, R. C.
AU  - Kolonel, L. N.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 23
SP  - 1906
EP  - 1916
SN  - 0027-8874
AD  - Alavanja, M. C. R.: Division of Cancer Etiology, National Cancer Institute, 6130 Executive Blvd., Rm. 543, Rockville, MD 20852, USA.
N1  - Accession Number: 19942028027.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A telephone-administered questionnaire was used to determine and/or verify eligibility with regard to age, gender, race, and smoking status. In a second interview at the participant's home, a widely used food frequency questionnaire was filled out, and logistic regression was subsequently used to analyse the responses. [The authors] obtained dietary information on 429 case subjects who had a diagnosis of lung cancer reported to the Missouri Cancer Registry (USA) between June 1, 1986, and June 1, 1991, and 1021 control subjects. A strongly increasing trend in lung cancer risk was observed with increased saturated fat consumption among these non-smoking women; the relative risk was more than six-fold greater for the highest quintile of consumption than for the lowest quintile. The effect of saturated fat was more pronounced for adenocarcinoma than for other cell types. Weekly servings of beans and peas were significantly related to decreased lung cancer risk, while citrus fruit and juice showed a two-fold increase in risk; this trend was also significant. The authors conclude that by focusing on non-smoking women with lung cancer, including a large number with adenocarcinoma, a clear association with saturated fat consumption was observed that may have been masked in earlier studies of lung cancer involving a high percentage of smokers. [This topic is also discussed in an editorial by Laurence N. Kolonel on p. 1886 of this issue.] From AS
KW  - diet
KW  - dietary fat
KW  - fat
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - Nutrition
KW  - risk
KW  - women
KW  - Missouri
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancer sites
KW  - cancers
KW  - source fat
KW  - United States of America
KW  - Women (UU500) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow.
AU  - Sandler, D. P.
AU  - Shore, D. L.
AU  - et al.
AU  - Anderson, J. R. (
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1993///
VL  - 85
IS  - 24
SP  - 1994
EP  - 2003
SN  - 0027-8874
AD  - Sandler, D. P.: National Institute of Environmental Health Sciences, Mail Drop A3-05, PO Box 12233, Research Triangle Park, NC 27703, USA.
N1  - Accession Number: 19942027222.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors' purpose was to investigate the leukaemia risk associated with cigarette smoking in a multicentre case-control study of acute leukaemias. Adults aged 18-79 with newly diagnosed leukaemia were contacted to participate in this epidemiological study when they entered a clinical trial to be treated under protocols sponsored by Cancer and Leukaemia Group B. Smoking histories for 610 patients with acute leukaemia and 618 population control subjects were obtained by telephone interviews. The authors calculated odds ratio (ORs) for risk of leukaemia associated with smoking cigarettes. ORs were adjusted for age, race, and sex. Smoking was associated only with a modest increase in risk for leukaemia overall (adjusted OR = 1.13, 95% confidence interval [CI] = 0.89-1.44). However, among participants aged 60 and older, smoking was associated with a two-fold increase in risk for acute myeloid leukaemia (AML) (OR = 1.96; 95% CI = 1.17-3.28) and a three-fold increase in risk for acute lymphocytic leukaemia (ALL) (OR = 3.40; 95% CI = 0.97-11.9). Among older persons, risks increased with amount and duration of smoking. Smoking was associated with increased risk for AML classified as FAB type M2 at all ages, with ORs of 1.70 (95% CI = 1.00-2.90) for those younger than 60 and 3.50 (95% CI = 1.53-8.03) for those aged 60 and older. Smoking was also associated with ALL type L2 at all ages, with ORs of 1.72 (95% CI = 0.90-3.27) for those younger than 60 and 5.34 (95% CI = 1.03-27.6) for those who were older. Smoking was more common among patients with specific chromosome abnormalities in AML [-7 or 7q, -Y, +13] and in ALL [t(9;22)(q34;q11)]. The authors conclude that cigarette smoking is associated with increased risk for leukaemia and may lead to leukaemias of specific morphologic and chromosomal types. The association varies with age. Examining discrete subtypes of disease may permit more accurate assessment of risk. From AS
KW  - leukaemia
KW  - risk factors
KW  - Tobacco smoking
KW  - blood cancer
KW  - leucaemia
KW  - leukemia
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemotherapy for patients with pulmonary Kaposi's sarcoma: benefit of filgrastim (G-CSF) in supporting dose administration.
AU  - Sloand, E.
AU  - Kumar, P. N.
AU  - Pierce, P. F.
JO  - Southern Medical Journal
JF  - Southern Medical Journal
Y1  - 1993///
VL  - 86
IS  - 11
SP  - 1219
EP  - 1224
SN  - 0038-4348
AD  - Sloand, E.: National Institutes of Health, Building 31, Room 5A49, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005457.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Clinical aspects
KW  - drug therapy
KW  - HIV infections
KW  - Kaposi's sarcoma
KW  - lungs
KW  - Treatment
KW  - AIDS
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Correlates of HIV risk behaviour among HIV infected prisoners.
AU  - Grace, W. C.
T2  - Addiction
JO  - Addiction
JF  - Addiction
Y1  - 1993///
VL  - 88
IS  - 6
SP  - 836
EP  - 836
SN  - 0965-2140
AD  - Grace, W. C.: National Institute on Drug Abuse, Room 11A-33, Rockville, MD 20857, USA.
N1  - Accession Number: 19942024283.  Publication Type: Correspondence.  Language: English. 
KW  - behaviour
KW  - HIV infections
KW  - Prevention
KW  - Prisoners
KW  - Risk behaviour
KW  - Sociology
KW  - behavior
KW  - human immunodeficiency virus infections
KW  - risk behavior
KW  - social aspects
KW  - Social research
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A randomized, controlled trial of recombinant α-interferon therapy for chronic hepatitis B.
AU  - Bisceglie, A. M. di
AU  - Fong, T. L.
AU  - Fried, M. W.
AU  - Swain, M. G.
AU  - Baker, B.
AU  - Korenman, J.
AU  - Bergasa, N. V.
AU  - Waggoner, J. G.
AU  - Park, Y.
AU  - Hoofnagle, J. H.
JO  - American Journal of Gastroenterology
JF  - American Journal of Gastroenterology
Y1  - 1993///
VL  - 88
IS  - 11
SP  - 1887
EP  - 1892
SN  - 0002-9270
AD  - Bisceglie, A. M. di: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.
N1  - Accession Number: 19952007253.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 9008-11-1. 
N2  - The authors evaluated the effect of recombinant α-interferon in chronic hepatitis B. Patients in Maryland, USA were stratified at entry according to their serum aspartate aminotransferase (AST) values, randomized to receive α-interferon (alfa-2b, 10 million units three times weekly) or to be untreated controls for 16 weeks. Effect of therapy on levels of hepatitis B viral (HBV) DNA and aminotransferase activities in serum and hepatitis B e antigen (HBeAg) status was monitored. Forty-seven patients entered the trial; 11 of 25 (44%) patients receiving interferon responded by clearing HBeAg and HBV DNA within 6 months, compared to one of 22 (5%) controls (P &lt;0.05). Among those with serum AST values &lt;100 U/L, 33% responded and among those with AST values &gt;100 U/L, 60% responded. Within the 6-month study period, 36% of treated patients had normal serum alanine aminotransferase (ALT) values, and 16% had cleared hepatitis B surface antigen (HBsAg) from serum, whereas none of the controls had normal ALT values or had lost HBsAg. Interferon was stopped early in three patients (6.5%), and dosage was reduced in a further 16 patients (35%) because of adverse effects. Predictive factors for a response were the pretreatment serum ALT and AST activities. α-Interferon therapy (three times weekly) is relatively well tolerated and is effective in clearing HBeAg and HBV DNA in approximately one-third of treated patients.
KW  - chronic course
KW  - chronic infections
KW  - hepatitis B
KW  - immunotherapy
KW  - interferon
KW  - Maryland
KW  - North America
KW  - USA
KW  - hepatitis B virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance.
AU  - Actor, J. K.
AU  - Shirai, M.
AU  - Kullberg, M. C.
AU  - Buller, R. M. L.
AU  - Sher, A.
AU  - Berzofsky, J. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 3
SP  - 948
EP  - 952
SN  - 0027-8424
AD  - Actor, J. K.: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940800937.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Helminthology
N2  - Schistosoma mansoni-infected BALB/c mice, were challenged when cytokine imbalance was prominent, with a recombinant vaccinia virus expressing human immunodeficiency virus type 1 gp160. In contrast to control vaccinia-infected animals, S. mansoni plus vaccinia-infected mice did not produce significant Th1 cytokine responses upon in vitro stimulation with recombinant gp120, consistent with previous results for nonparasite antigens. However, more striking was the downregulation of the virus-specific CTL response not previously studied. Spleen cells from vaccinia-infected control mice displayed strong CD8+ cytolytic activity against gp160-transfected fibroblasts and fibroblasts pulsed with a peptide (P18) representing a CTL epitope of gp160. In contrast, mice coinfected with S. mansoni and vaccinia manifested absent or markedly reduced in vitro CTL activity even in the presence of exogenous interleukin 2. To determine whether this immune dysregulation might impact on viral clearance, virus titres were measured in tissues as a function of time. Mice infected with vaccinia virus alone rapidly cleared the virus, whereas in animals coinfected with S. mansoni, viral clearance was delayed by as much as 3 weeks in the liver and by several days in the spleen and lungs. These observations suggest that helminth infection may influence immune responses to concurrent viral infections.
KW  - experimental infections
KW  - helminthoses
KW  - helminths
KW  - HIV infections
KW  - human diseases
KW  - immunological deficiency
KW  - Immunology
KW  - laboratory animals
KW  - mixed infections
KW  - parasites
KW  - Schistosomiasis
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - vaccinia virus
KW  - viruses
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - bilharzia
KW  - bilharziasis
KW  - human immunodeficiency virus infections
KW  - immune deficiency
KW  - immunodeficiency
KW  - multiple infections
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hepatitis C virus RNA in southern African blacks with hepatocellular carcinoma.
AU  - Bukh, J.
AU  - Miller, R. H.
AU  - Kew, M. C.
AU  - Purcell, R. H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 5
SP  - 1848
EP  - 1851
SN  - 0027-8424
AD  - Bukh, J.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932022434.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - A sensitive and specific cDNA polymerase chain reaction (PCR) assay was used to detect hepatitis C virus (HCV) RNA in serum samples from 128 unselected southern African Blacks with hepatocellular carcinoma (HCC). HCV-RNA was found in 26 (20.3%). A first-generation ELISA for serum HCV antibodies gave only poor correlation with PCR results. With a second-generation ELISA (Abbott), anti-HCV was detected in 25 patients (19.5%), and 17 of these patients were positive for HCV-RNA. By application of a second-generation recombinant immunoblot assay (Chiron), anti-HCV positivity was confirmed in 14 of the 17 ELISA- and HCV-RNA-positive patients: 2 were indeterminate and 1 was anti-HCV negative. All 8 patients who were ELISA-antibody positive but HCV-RNA negative, were anti-HCV negative by immunoblot. Five patients were HCV-RNA positive, but antibody negative on both ELISAs. The mean age of HCC patients positive for HCV-RNA (52.3 years) was significantly higher (P &lt;0.001) than that of negative patients (40.3 years). Patients positive for HCV-RNA were more likely to be urban dwellers than were negative patients. Seventy one patients (55.5%) had evidence of current hepatitis B virus (HBV) infection (positive for serum HBV-encoded surface antigen (HBsAg) and HBV core antibodies (anti-HBc)), and 50 patients (39.1%) had evidence of previous infection (positive for serum HBV surface antibodies (anti-HBs) and/or anti-HBc): only 7 (5.5%) had no evidence of current or previous infections by HBV. The prevalence of current HBV infection was significantly lower (P &lt;0.001) in patients who were positive for HCV-RNA (7/26, 26.9%) than in those who were negative (64/102, 62.7%) a difference which was not dependent on gender, age, or geographical location (rural or urban) of the patients. A significant number of southern African Blacks with HCC had a current HCV but not a current HBV infection (19/128, 14.8%), suggesting that infection with HCV plays a role in the development of HCC in some members of this population. [The contributions of infections by HBV and HCV to HCC in the study population can be gauged by (i) 64 patients (50.0%) having current HBV alone, (ii) 35 (27.3%) having previous HBV alone, (iii) 15 (11.7%) having previous HBV and current HCV, (iv) 7 (5.5%) having current HBV and current HCV, (v) 4 (3.1%) having current HCV alone, and (vi) 3 (2.3%) having no infection. An earlier publication gave data on 152 control subjects, of whom (i) 9 (5.9%) had current HBV, and (ii) 75 (49.3%) had previous HBV, of whom 1 (0.7%) had anti-HCV antibodies (on radioimmunoassay) (M.C. Kew et al., Lancet, 1990, 335, 873).] Alan F. Fleming
KW  - Hepatitis C
KW  - liver
KW  - liver cancer
KW  - neoplasms
KW  - Africa
KW  - South Africa
KW  - hepatitis C virus
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Southern Africa
KW  - Africa South of Sahara
KW  - Threshold Countries
KW  - cancer sites
KW  - cancers
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease.
AU  - Shahabuddin, M.
AU  - Toyoshima, T.
AU  - Aikawa, M.
AU  - Kaslow, D. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 9
SP  - 4266
EP  - 4270
SN  - 0027-8424
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940500402.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 103782-08-7, 9001-06-3.  Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2  - During development of the mosquito midgut, malarial parasites must traverse a chitin-containing peritrophic matrix (PM) that forms around the food bolus. It was previously reported by M. Huber et al. (1991) [Proceedings of the National Academy of Sciences of the United States of America, 88: 2807-2810] that the parasite secretes a protein with chitinase activity and they suggested that parasite chitinase plays an important role in the parasite's egress from the blood meal. Now, it has been found, using Aedes aegypti/Plasmodium gallinaceum and Anopheles freeborni/P. falciparum systems, that allosamidin, a specific inhibitor of chitinase, completely blocked oocyst development in vivo and thus blocked malaria parasite transmission. Addition of exogenous chitinase to the blood meal prevented the PM from forming and reversed the transmission-blocking activity of allosamidin. Using exogenous chitinase, it was found that the PM does not limit the number of parasites that develop into oocysts, suggesting that the parasite produces sufficient quantities of chitinase to penetrate this potential barrier. In addition, it was found that treatment of parasite chitinase with a diisopropyl fluorophosphate-sensitive trypsin-like protease from the mosquito midgut or endoproteinase Lys-C increased its enzymatic activity. These results suggest that malaria parasites have evolved an intricate mechanism to adapt to the PM and the protease-rich environment of the mosquito midgut.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;During development in the mosquito midgut, malarial parasites must traverse a chitin-containing peritrophic matrix (PM) that forms around the food bolus. Previously Huber et al. (Huber, M., Cabib, E. and Miller, L.H. (1991) Proc. Natl. Acad. Sci., USA 88, 2807-2810) reported that the parasite secretes a protein with chitinase activity, and they suggested that parasite chitinase (EC 3.2.1.14) plays an important role in the parasite's egress from the blood meal. [The authors] found that allosamidin, a specific inhibitor of chitinase, completely blocked oocyst development in vivo and thus blocked malaria parasite transmission. Addition of exogenous chitinase to the blood meal prevented the PM from forming and reversed the transmission-blocking activity of allosamidin. Using exogenous chitinase, [the authors] also found that the PM does not limit the number of parasites that develop into oocysts, suggesting that the parasite produces sufficient quantities of chitinase to penetrate this potential barrier. In addition, [the authors] found that treatment of parasite chitinase with a diisopropyl fluorophosphate-sensitive trypsinlike protease from the mosquito midgut or endoproteinase Lys-C increased its enzymatic activity. These results suggest that malaria parasite has evolved an intricate mechanism to adapt to the PM and the protease-rich environment of the mosquito midgut. AS
KW  - allosamidin
KW  - chitinase
KW  - disease transmission
KW  - disease vectors
KW  - enzymes
KW  - human diseases
KW  - infection
KW  - infections
KW  - ookinetes
KW  - parasites
KW  - peritrophic membrane
KW  - transmission
KW  - Aedes aegypti
KW  - Anopheles freeborni
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium
KW  - chitinase activity
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variant-specific surface proteins of Giardia lamblia are zinc-binding proteins.
AU  - Nash, T. E.
AU  - Mowatt, M. R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 12
SP  - 5489
EP  - 5493
SN  - 0027-8424
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950807844.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 52-90-4. 
N2  - Giardia lamblia [G. duodenalis] undergoes surface antigen variation. The variant-specific surface proteins (VSPs) are a distinct family of cysteine-rich proteins. Characteristically, cysteine residues occur mostly as CXXC tetrapeptides. Four of the reported 5 VSPs contain a putative metal-binding domain that resembles other metal-binding motifs; the fifth is closely related but lacks an essential histidine. Three different native VSPs bound Zn2+, Co2+, Cu2+ and Cd2+ inhibited Zn2+ binding. Analysis of recombinant VSP fusion proteins showed that the putative binding motif bound Zn2+. Peptide fragments from other regions of the VSP contain CXXCXetaCXXC motifs that also bound Zn2+. Analysis of deduced amino acid sequences showed well-conserved CXXC spacing in three out of five VSPs, suggesting conservation of structure despite amino acid sequence divergence. The function of VSPs is unknown, but by binding Zn2+ or other metals in the intestine, VSPs may contribute to Zn2+ malnutrition or inhibition of metal-dependent intestinal enzymes, which would lead to malabsorption, a known consequence of giardiasis.
KW  - antigens
KW  - binding proteins
KW  - cysteine
KW  - malabsorption
KW  - nucleotide sequences
KW  - recombinant DNA
KW  - surface antigens
KW  - Giardia duodenalis
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - carrier proteins
KW  - DNA sequences
KW  - immunogens
KW  - malabsorption syndrome
KW  - zinc binding proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts.
AU  - Gazzinelli, R. T.
AU  - Hieny, S.
AU  - Wynn, T. A.
AU  - Wolf, S.
AU  - Sher, A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 13
SP  - 6115
EP  - 6119
SN  - 0027-8424
AD  - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932024089.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Immunity against the intracellular protozoan Toxoplasma gondii is highly dependent on interferon γ (IFN-γ). [The authors] have previously shown that, in addition to T lymphocytes, natural killer (NK) cells can be stimulated by the parasite to produce this cytokine by a reaction requiring adherent accessory cells and tumour necrosis factor α. [The authors] now demonstrate that a recently characterized cytokine, interleukin 12 (IL-12), is also necessary for parasite-induced IFN-γ synthesis by NK cells. Anti-IL-12 antibodies completely inhibited T. gondii or bacterial endotoxin-stimulated IFN-γ production by NK-enriched spleen cells from severe combined immunodeficient mice. Moreover, potent NK cytokine responses were induced by the combination of IL-12 and tumour necrosis factor α. In addition, adherent spleen cells from scid/scid mice or thyoglycollate-elicited macrophages from BALB/c animals produced high levels of both IL-12 (p40) and tumour necrosis factor α mRNAs when exposed to either live tachyzoites, parasite extracts, or endotoxin, confirming that these cytokines are produced by accessory cells. Finally, in vivo studies showed that treatment with recombinant IL-12 results in prolonged survival of scid mice after infection with T. gondii by means of a response dependent on both IFN-γ and NK cells. Together the data argue that IL-12 is required for the T-cell-independent triggering of NK cells by intracellular parasites and that the cytokine may be useful for inducing this protective pathway in immunodeficient hosts.AS
KW  - immunology
KW  - natural killer cells
KW  - Toxoplasma gondii
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection.
AU  - Graziosi, C.
AU  - Pantaleo, G.
AU  - et al.
AU  - Butini, L. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 14
SP  - 6405
EP  - 6409
SN  - 0027-8424
AD  - Graziosi, C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004853.  Publication Type: Journal Article.  Language: English. 
KW  - antigenaemia
KW  - cellular biology
KW  - core protein p24
KW  - Dynamics
KW  - HIV infections
KW  - Immunology
KW  - Pathogenesis
KW  - Pathology
KW  - replication
KW  - T lymphocytes
KW  - viral replication
KW  - viruses
KW  - antigenemia
KW  - cell biology
KW  - human immunodeficiency virus infections
KW  - p24
KW  - p24 antigen
KW  - T cells
KW  - Viral burden
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.
AU  - Barillari, G.
AU  - Gendelman, R.
AU  - Gallo, R. C.
AU  - Ensoli, B.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 17
SP  - 7941
EP  - 7945
SN  - 0027-8424
AD  - Barillari, G.: (B. Ensoli) Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005415.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - adhesion
KW  - cells
KW  - Kaposi's sarcoma
KW  - Pathogenesis
KW  - AIDS
KW  - Growth promotion
KW  - Tat
KW  - Vascular cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS.
AU  - Lisziewicz, J.
AU  - Sun, D.
AU  - et al.
AU  - Smythe, J. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 17
SP  - 8000
EP  - 8004
SN  - 0027-8424
AD  - Lisziewicz, J.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005416.  Publication Type: Journal Article.  Language: English. 
KW  - Antiviral agents
KW  - Gene therapy
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - RNA decoy
KW  - Tat activation response elements
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication.
AU  - Gao, W. Y.
AU  - Cara, A.
AU  - Gallo, R. C.
AU  - Lori, F.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 19
SP  - 8925
EP  - 8928
SN  - 0027-8424
AD  - Gao, W. Y.: (F. Lori) Building 37, Room 6A09, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005063.  Publication Type: Journal Article.  Language: English.  Registry Number: 127-07-1. 
KW  - HIV infections
KW  - hydroxycarbamide
KW  - Inhibitors
KW  - Latent infections
KW  - replication
KW  - Treatment
KW  - viral replication
KW  - viruses
KW  - Deoxynucleoside metabolism
KW  - DNA synthesis
KW  - human immunodeficiency virus infections
KW  - hydroxyurea
KW  - latency
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005063&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes.
AU  - Rice, W. G.
AU  - Schaeffer, C. A.
AU  - Graham, L.
AU  - Bu, M.
AU  - McDougal, J. S.
AU  - Orloff, S. L.
AU  - Villinger, F.
AU  - Young, M.
AU  - Oroszlan, S.
AU  - Fesen, M. R.
AU  - Pommier, Y.
AU  - Mendeleyev, J.
AU  - Kun, E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
IS  - 20
SP  - 9721
EP  - 9724
SN  - 0027-8424
AD  - Rice, W. G.: Laboratory of Antiviral Drug Mechanism, Program Resources, Inc./DynCorp., National Cancer Institute-Frederick Cancer Research and Development Center, Building 431 T-B, PO Box B, Frederick, MD 21702, USA.
N1  - Accession Number: 19942050413.  Publication Type: Journal Article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - HIV infections
KW  - nitroso compounds
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - nitrosobenzamide
KW  - viral synthesis inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050413&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.
AU  - Goldfarb, L. G.
AU  - Brown, P.
AU  - Haltia, M.
AU  - Ghiso, J.
AU  - Frangione, B.
AU  - Gajdusek, D. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
SP  - 4451
EP  - 4454
SN  - 0027-8424
AD  - Goldfarb, L. G.: Building 36, Room 5B21, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932022400.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - peptides
KW  - purification
KW  - synthesis
KW  - Creuzfeldt-Jakob disease
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022400&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system.
AU  - Whitesell, L.
AU  - Geselowitz, D.
AU  - et al.
AU  - Chavany, C. (
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1993///
VL  - 90
SP  - 4665
EP  - 4669
SN  - 0027-8424
AD  - Whitesell, L.: Clinical Pharmacology Branch, National Cancer Institute, Building 10, Room 13N262, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932022402.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrospinal fluid penetration
KW  - Oligodeoxynucleotide
KW  - phosphorothioate
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022402&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Variation of lipoprotein(a) concentrations among individuals with the same apolipoprotein(a) isoform is determined by the rate of lipoprotein(a) production.
AU  - Rader, D. J.
AU  - Cain, W.
AU  - Zech, L. A.
AU  - Usher, D.
AU  - Brewer, H. B., Jr.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1993///
VL  - 91
IS  - 2
SP  - 443
EP  - 447
SN  - 0021-9738
AD  - Rader, D. J.: Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 7N117, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941403848.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - A series of kinetic studies were performed using purified radiolabelled lipoprotein(a) (Lp(a)) in subjects (7 men, 3 women; 20 to 39 years old) with the same apolipoprotein(a) (apo(a)) isoform but different Lp(a) values. In 7 subjects with a single S4-apo(a) isoform and Lp(a) ranging from 1 to 13.2 mg/100 ml, the fractional catabolic rate (FCR) of 131labelled S2-Lp(a) (mean 0.328 per day) was not correlated with the plasma Lp(a) value (r = -0.346, P=0.45). In 2 S4-apo(a) subjects with a 10-fold difference in Lp(a) value, the FCRs of 125I-labelled S4-Lp(a) were similar in both subjects and not substantially different from the FCRs of 131I-S2-Lp(a) in the same subjects. In 4 subjects with a single S2-apo(a) isoform and Lp(a) values ranging from 9.4 to 91 mg/100 ml, Lp(a) concentration was highly correlated with Lp(a) production rate (r = 0.993, P=0.007), but poorly correlated with Lp(a) FCR (mean 0.304 per day). Analysis of Lp(a) kinetic parameters in all subjects revealed no significant correlation of Lp(a) value with Lp(a) FCR (r = -0.53, P=0.09) and a strong correlation with Lp(a) production rate (r = 0.99, P&lt;0.0001). It is concluded that the substantial variation in Lp(a) values among persons with the same apo(a) phenotype is caused primarily by differences in Lp(a) production rate.
KW  - apolipoproteins
KW  - blood
KW  - cardiovascular diseases
KW  - genetic polymorphism
KW  - lipoproteins
KW  - metabolism
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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TY  - JOUR
T1  - In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
AU  - Karp, C. L.
AU  - El-Safi, S. H.
AU  - Wynn, T. A.
AU  - Satti, M. M. H.
AU  - Kordofani, A. M.
AU  - Hashim, F. A.
AU  - Hag-Ali, M.
AU  - Neva, F. A.
AU  - Nutman, T. B.
AU  - Sacks, D. L.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1993///
VL  - 91
IS  - 4
SP  - 1644
EP  - 1648
SN  - 0021-9738
AD  - Karp, C. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804909.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9008-11-1, 130068-27-8.  Subject Subsets: Protozoology; Tropical Diseases
N2  - To assess lesional cytokine profiles in Sudanese patients with kala-azar, bone marrow aspirates from 10 patients with active kala-azar, 5 with treated kala-azar, 2 endemic controls and 2 USA controls were analysed using a quantitative reverse transcriptase polymerase chain reaction (PCR) technique to amplify specific mRNA sequences of multiple Th1-, Th2-, and/or macrophage-associated cytokines. Transcript levels of IL-10 as well as IFN-γ were significantly elevated in patients with active visceral leishmaniasis; IL-10 levels decreased markedly with resolution of disease. These findings suggest that IL-10 may contribute to the pathogenesis of kala-azar by inhibiting the cytokine-mediated activation of host macrophages that is necessary for the control of Leishmania donovani infection.\From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;To assess lesional cytokine profiles in Sudanese patients with kala-azar, bone marrow aspirates from 10 patients with active kala-azar, 5 with treated kala-azar, 2 endemic controls and 2 USA controls were analysed using a quantitative reverse transcriptase polymerase chain reaction (PCR) technique to amplify specific mRNA sequences of multiple Th1-, Th2-, and/or macrophage-associated cytokines. Transcript levels of IL-10 as well as IFN-γ were significantly elevated in patients with active visceral leishmaniasis; IL-10 levels decreased markedly with resolution of disease. These findings suggest that IL-10 may contribute to the pathogenesis of kala-azar by inhibiting the cytokine-mediated activation of host macrophages that is necessary for the control of Leishmania donovani infection.
KW  - Cytokines
KW  - Human diseases
KW  - immune response
KW  - Interferon
KW  - Interleukin 10
KW  - Molecular genetics
KW  - parasites
KW  - pathogenesis
KW  - Polymerase chain reaction
KW  - Visceral leishmaniasis
KW  - Africa
KW  - Sudan
KW  - Leishmania donovani
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - ACP Countries
KW  - East Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - biochemical genetics
KW  - immunity reactions
KW  - immunological reactions
KW  - PCR
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Induction of humoral and cell-mediated anti-human immunodeficiency virus (HIV) responses in HIV sero-negative volunteers by immunization with recombinant gp160.
AU  - Kovacs, J. A.
AU  - Vasudevachari, M. B.
AU  - et al.
AU  - Easter, M. (
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1993///
VL  - 92
IS  - 2
SP  - 919
EP  - 928
SN  - 0021-9738
AD  - Kovacs, J. A.: Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005895.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - This paper presents the results of a phase I/II trial of an HIV candidate vaccine in HIV-seronegative people, based on the recombinant gp160 manufactured by MicroGeneSys. [This is the preparation that has been used as a therapeutic vaccine in HIV-seropositive subjects and gained notoriety when the US Congress voted $20 million for a phase III study using the product, a decision which was rescinded after many protests from the scientific community that the trial should have been peer reviewed and that more than one candidate therapeutic vaccine should be tried.] The study used gp160 conjugated to alum and was administered intravascularly in a variety of doses (10-1280 µg) with several boosting schedules given up to 24 months. Antibody responses were detected with epitope-specific ELISAs, immunoblots and immunoneutralizing assays. Blastogenic responses were also determined. For the trial 138 volunteers (mean age 36 years) were enrolled. Antibody responses were seen in the group receiving 3 immunizations with 160 µg although maximal responses were elicited with three doses of 1280 µg. Titres fell after challenge although a rapid anamnestic response was seen after re-challenge. Responses to some epitopes such as the second conserved domain were seen more frequently than after natural infection. Neutralizing responses were [unfortunately] homologous and did not recognize heterologous strains. Blastogenic responses were seen following doses of 20 µg or higher and were usually sustained for &gt;1 year, especially when the dose exceeded 160 µg. Heterologous recognition was seen but there was no response to SIV. The specificity of the response was determined by comparing the responses to some of the volunteers who received keyhole limpet haemocyanin. [The authors conclude that the vaccine is safe and immunogenic even though three volunteers developed autoimmune diseases. Although this was not an efficiency study, one of the volunteers who did not make an immune response became HIV positive after the study had finished.] A.G. Dalgleish
KW  - envelope protein gp160
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - Immune response
KW  - Immunization
KW  - Immunology
KW  - Safety
KW  - Vaccines
KW  - North America
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - conjugated vaccines
KW  - gp160
KW  - Human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein.
AU  - Rader, D. J.
AU  - Schäfer, J.
AU  - Lohse, P.
AU  - Verges, B.
AU  - Kindt, M.
AU  - Zech, L. A.
AU  - Steinmetz, A.
AU  - Brewer, H. B., Jr.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1993///
VL  - 92
IS  - 2
SP  - 1009
EP  - 1017
SN  - 0021-9738
AD  - Rader, D. J.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951409621.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
KW  - atherosclerosis
KW  - catabolism
KW  - cholesterol
KW  - high density lipoprotein
KW  - kinetics
KW  - transport
KW  - triacylglycerols
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - transportation
KW  - triglycerides
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.
AU  - King, C. L.
AU  - Mahanty, S.
AU  - Kumaraswami, V.
AU  - Abrams, J. S.
AU  - Regunathan, J.
AU  - Jayaraman, K.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1993///
VL  - 92
IS  - 4
SP  - 1667
EP  - 1673
SN  - 0021-9738
AD  - King, C. L.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804884.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2, 76057-06-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - The immunological mechanisms involved in maintenance of an asymptomatic microfilaraemic state (MF) in patients with lymphatic filariasis remain undefined. MF patients have impaired filarial antigen (Ag)-specific lymphocyte proliferation and decreased frequencies (Fo) of Ag-specific T cells, and yet elevated serum IgE and antifilarial IgG4. To investigate the mechanism of Ag-specific anergy in MF patients in contrast to amicrofilaremic individuals with chronic lymphatic obstruction (CP), the Fo of Ag-specific lymphocytes from peripheral blood mononuclear cells secreting either IL-4 or IFN-γ were assessed by filter spot enzyme-linked immunosorbent assay, and IL-10 and transforming growth factor-β (TGF-β) mRNA transcript levels were assessed by a semiquantitative reverse transcriptase polymerase chain reaction technique. The Fo of filaria-specific IL-4-secreting lymphocytes were equivalent in both MF (geometric mean [GM] = 1:11 700) and CP (GM = 1:29 300), whereas the Fo of IFN-γ-secreting lymphocytes were lower in MF (GM = 1:39 300) than in CP (GM = 1:4 200). When the ratio of IL-4/IFN-γ (T helper type 2 [Th2]/Th1)-secreting cells was examined, MF subjects showed a predominant Th2 response (8:1) compared with a Th1 response in CP individuals (1:4). mRNA transcript levels of IL-10 were also significantly elevated in MF compared with CP individuals. Further, IL-10 and TGF-β were showed to have a role in modulating the Ag-specific anergy among MF subjects, in that neutralizing anti-IL-10 or anti-TGF-β significantly enhanced lymphocyte proliferation response (by 220-1300%) to filarial Ags in MF individuals. These findings demonstrated that MF subjects respond to parasite antigen by producing a set of suppressive cytokines that may facilitate persistence of the parasite within humans while producing little clinical disease.
KW  - cytokines
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunology
KW  - infections
KW  - interferon
KW  - interleukin 10
KW  - interleukin 4
KW  - interleukins
KW  - parasites
KW  - T lymphocytes
KW  - transforming growth factor
KW  - Brugia malayi
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leukotriene B4 and interleukin-8 in human immunodeficiency virus-related pulmonary disease.
AU  - Lipschik, G. Y.
AU  - Doerfler, M. E.
AU  - Kovacs, J. A.
AU  - Travis, W. D.
AU  - Andrawis, V. A.
AU  - Lawrence, M. G.
AU  - Dichter, J. R.
AU  - Ognibene, F. P.
AU  - Shelhamer, J. H.
JO  - Chest
JF  - Chest
Y1  - 1993///
VL  - 104
IS  - 3
SP  - 763
EP  - 769
SN  - 0012-3692
AD  - Lipschik, G. Y.: J. H. Shelhamer, Critical Care Department, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931251389.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 142298-00-8.  Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - Bronchoalveolar lavage (BAL) fluid samples from 5 normal volunteers, 5 asymptomatic HIV-positive patients, 10 HIV-positive patients with non-specific interstitial pneumonitis (NIP) and 19 HIV-positive patients with Pneumocystis carinii pneumonia (PCP) were analysed in order to investigate the pathogenesis of lung injury in PCP and NIP. Interleukin-8 (IL-8) and phospholipase A2 (PLA2) were elevated in patients with PCP, and IL-8 correlated with BAL fluid absolute neutrophil count. Leukotriene B4 (LTB4), IL-8 and PLA2 levels were elevated in patients with NIP; LTB4 and PLA2 levels correlated with absolute neutrophil count, and IL-8 correlated with alveolar-arterial oxygen pressure difference. IL-8 was elevated in the asymptomatic HIV-positive patients and there was a trend toward elevation of PLA2 in this group. It is concluded that IL-8 plays a role in the pathogenesis of lung injury in PCP and that IL-8 may be the principal neutrophil chemotaxin in this disease. PLA2 may also be involved in the pathogenesis of PCP, and LTB4 and IL-8 may be involved in the recruitment of neutrophils and subsequent lung injury of NIP. It is suggested that there are varying mechanisms by which inflammatory cells are recruited in the lung in different HIV-related diseases.
KW  - acquired immune deficiency syndrome
KW  - cytokines
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - immunology
KW  - infections
KW  - interleukin 8
KW  - interleukins
KW  - leukotrienes
KW  - lungs
KW  - opportunistic infections
KW  - parasites
KW  - pathogenesis
KW  - predisposition
KW  - North America
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DB  - lhh
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TY  - JOUR
T1  - The discovery of the hepatitis viruses.
AU  - Purcell, R. H.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1993///
VL  - 104
IS  - 4
SP  - 955
EP  - 963
SN  - 0016-5085
AD  - Purcell, R. H.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020655.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - history
KW  - Hepatitis viruses
KW  - History and Biography (BB500) 
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ER  - 

TY  - JOUR
T1  - Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B.
AU  - Hoofnagle, J. H.
AU  - Bisceglie, A. M. di
AU  - Waggoner, J. G.
AU  - Park, Y.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1993///
VL  - 104
IS  - 4
SP  - 1116
EP  - 1121
SN  - 0016-5085
AD  - Hoofnagle, J. H.: National Institutes of Health, Building 10, Room 9C103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020657.  Publication Type: Journal Article.  Language: English.  Registry Number: 9008-11-1.  Subject Subsets: Public Health
N2  - ... Between 1984 and 1991, 18 patients with clinically-apparent cirrhosis due to hepatitis B were treated with interferon alfa at the Clinical Center of the National Institutes of Health [Maryland, USA]. Six treated patients (33%) had a sustained loss of hepatitis B virus DNA and hepatitis B e antigen (if present initially) and decrease of amino-transferase levels into the normal or near normal range. In follow-up, these 6 patients resolved all symptoms of cirrhosis and are alive and fully active. In contrast, the 12 patients who did not have a sustained loss of hepatitis B virus have had evidence of progressive liver disease, 6 have died and 4 underwent hepatic transplantation. Side effects of interferon were common and included bacterial infections (n = 5) and exacerbations of disease (n = 9). These findings indicate that interferon alfa is effective in selected patients with mildly decompensated cirrhosis due to hepatitis B. AS
KW  - chronic course
KW  - hepatitis
KW  - Hepatitis B
KW  - hepatitis C
KW  - interferon
KW  - treatment
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - alpha
KW  - alpha-interferon
KW  - America (North)
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Changes in hepatitis C virus antigen in liver with antiviral therapy.
AU  - Di Bisceglie, A. M.
AU  - Hoofnagle, J. H.
AU  - Krawczynski, K.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1993///
VL  - 105
IS  - 3
SP  - 858
EP  - 862
SN  - 0016-5085
AD  - Di Bisceglie, A. M.: Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19932023310.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Although it has recently become possible to detect hepatitis C viral antigens in liver biopsy specimens, the frequency and clinical significance of this finding remains uncertain. Therefore, 49 liver biopsy specimens from 35 patients [in the USA] with hepatitis C were studied [in 1987-1991] to make these assessments. Hepatitis C virus antigen was detected by immunofluorescence staining of snap-frozen liver biopsy sections. Hepatitis C virus antigen was present in 86% of patients; the amount and pattern of hepatitis C virus antigen staining did not correlate with the degree of hepatic injury as assessed by serum aminotransferase levels or liver histology or with the level of viral replication assessed by the titer of HCV RNA in serum. Patients who had a beneficial response to antiviral therapy had significantly less hepatitis C virus antigen staining in pretreatment liver biopsy specimens than those who did not respond. The degree of hepatitis C virus antigen staining decreased significantly following interferon-α therapy but not after ribavirin therapy. Hepatic hepatitis C virus antigen became undetectable after therapy in those patients who had a long-term beneficial response to therapy. [The authors conclude that] hepatic hepatitis C virus staining may be useful in predicting and monitoring the response to antiviral therapy. AS
KW  - antigens
KW  - antiviral agents
KW  - drug therapy
KW  - Hepatitis C
KW  - liver
KW  - therapy
KW  - antigenicity
KW  - chemotherapy
KW  - immunogens
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The origin of parasitophorous vacuole membrane lipids in malaria-infected erythrocytes.
AU  - Ward, G. E.
AU  - Miller, L. H.
AU  - Dvorak, J. A.
JO  - Journal of Cell Science
JF  - Journal of Cell Science
Y1  - 1993///
VL  - 106
IS  - 1
SP  - 237
EP  - 248
SN  - 0021-9533
AD  - Ward, G. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804660.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - During invasion of an erythrocyte by a malaria merozoite, an indentation develops in the erythrocyte surface at the point of contact between the 2 cells. This indentation deepens as invasion progresses, until the merozoite is completely surrounded by a membrane known as the parasitophorous vacuole membrane (PVM). Fluorescent lipophilic probes and phospholipid analogues were incorporated into the erythrocyte membrane, and their fate was followed during PVM formation (by Plasmodium knowlesi) with low-light-level video fluorescence microscopy. The concentration of probe in the forming PVM was indistinguishable from the concentration of probe in the erythrocyte membrane, suggesting that the lipids of the PVM are continuous with and derived from the host cell membrane during invasion. In contrast, fluorescently-labelled erythrocyte surface proteins were largely excluded from the forming PVM. The data are consistent with a model for PVM formation in which the merozoite induces a localized invagination in the erythrocyte lipid bilayer, concomitant with a localized restructuring of the host cell cytoskeleton.
KW  - cell invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - lipids
KW  - membranes
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - blood red cells
KW  - lipins
KW  - parasite host relationships
KW  - parasitophorous vacuole
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of a two-dose measles, mumps, and rubella vaccination schedule in a cohort of college athletes.
AU  - Coté, T. R.
AU  - Sivertson, D.
AU  - Horan, J. M.
AU  - Lindegren, M.L.
AU  - Dwyer, D. M.
JO  - Public Health Reports
JF  - Public Health Reports
Y1  - 1993///
VL  - 108
IS  - 4
SP  - 431
EP  - 435
SN  - 0033-3549
AD  - Coté, T. R.: VEB-NCI, National Institutes of Health, 6130 Executive Blvd., EPN-434, Rockville, MD 20852, USA.
N1  - Accession Number: 19942028360.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - ... To determine seroprevalence and response to vaccination in seronegative persons, [the authors] tested sera from 256 college athletes at a Maryland State [USA] college by enzyme-linked immunosorbent assay, vaccinated seronegatives, then re-tested vaccinees. High school records were obtained for persons seronegative to measles. Of 256 students, 53 (21%) were seronegative to measles alone, 13 (5%) were seronegative to rubella alone, and 5 (2%) were seronegative to both. Among those seronegative to measles, 86% had previously received a dose of measles vaccine. After vaccination, 37 persons initially seronegative to measles and 9 seronegative to rubella were 97% and 100% seropositive, respectively. The high measles seroconversion rate suggests that the two-dose vaccine schedule should effectively control campus measles outbreaks and, if given as measles-mumps-rubella vaccine, will also improve immunity to rubella and mumps. AS
KW  - combined vaccines
KW  - dosage
KW  - immunization
KW  - measles
KW  - Measles mumps rubella vaccines
KW  - students
KW  - Maryland
KW  - North America
KW  - USA
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - immune sensitization
KW  - mixed vaccines
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial.
AU  - Rooney, J. F.
AU  - Straus, S. E.
AU  - et al.
AU  - Mannix, M. L. (
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1993///
VL  - 118
IS  - 4
SP  - 268
EP  - 272
SN  - 0003-4819
AD  - Rooney, J. F.: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Building 30, Room 121, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021064.  Publication Type: Journal Article.  Language: English.  Registry Number: 59277-89-3.  Subject Subsets: Public Health
N2  - Twenty-two otherwise healthy adults aged 18-50 years with at least two attacks of herpes labialis (one confirmed by viral culture) in a 4-month observation period were entered into a randomized double-blind placebo-controlled crossover study of acyclovir by the United States National Institutes for Dental Research and Allergy and Infectious Diseases. Acyclovir was given orally 400 mg twice daily for four months. Two patients withdrew from the study, one because of headache and nausea after 5 doses of acyclovir, and a second for administrative reasons. Recurrences were documented by clinical examination and viral culture. All isolates in the observation and therapy periods from the 20 remaining subjects were herpes simplex virus type 1 with in vitro sensitivities to acyclovir of less than 1.0 µg/ml. The average number of recurrences and virologically confirmed recurrences in the 4-month treatment periods were respectively 0.85 and 0.40 for acyclovir and 1.80 and 1.40 for placebo. The time to first recurrence on treatment was 118 days (22-134 days) for acyclovir recipients and 46 days (7-&gt;122 days) for placebo recipients (P = 0.05). After treatment was discontinued recurrent lesions developed on average after 28 days for both acyclovir and placebo recipients. This study shows that oral treatment with acyclovir is of value in the management of patients with frequent recurrent herpes labialis.D.S. Freestone
KW  - aciclovir
KW  - Herpes simplex
KW  - relapse
KW  - treatment
KW  - acyclovir
KW  - herpes simplex labialis
KW  - recurrence of disease
KW  - relapses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021064&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antibody response to Blastocystis hominis infections.
AU  - Zierdt, C. H.
AU  - Nagy, B.
T2  - Annals of Internal Medicine
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1993///
VL  - 118
IS  - 12
SP  - 985
EP  - 986
SN  - 0003-4819
AD  - Zierdt, C. H.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950802335.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Subject Subsets: Protozoology
N2  - The correspondent describes a study of the presence of antibodies to Blastocystis hominis in sera from 19 patients with symptomatic B. hominis infection. The average specific IgG antibody titre was 1/268 with indirect fluorescent testing and 1/405 with ELISA. The average titre for 50 normal (blood bank) sera was 1/24 by IFA and all normal sera were negative by ELISA. Titres for paired acute-phase sera were much higher than those reported for giardiasis, even though both parasites are non-invasive.
KW  - antibodies
KW  - giardiasis
KW  - human diseases
KW  - immune response
KW  - parasites
KW  - Blastocystis hominis
KW  - man
KW  - protozoa
KW  - Blastocystis
KW  - Amoebida incertae sedis
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - giardiosis
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802335&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Daily energy expenditure by five-year-old children, measured by doubly labeled water.
AU  - Fontvieille, A. M.
AU  - Harper, I. T.
AU  - Ferraro, R. T.
AU  - Spraul, M.
AU  - Ravussin, E.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1993///
VL  - 123
IS  - 2
SP  - 200
EP  - 207
SN  - 0022-3476
AD  - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19941405365.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Human Nutrition
N2  - Total energy expenditure (TEE) was estimated with doubly labelled water and resting metabolic rate (RMR) by indirect calorimetry in white children (15 boys 5.4±0.3 and 13 girls 5.5±0.4 years old). Measured TEE was 1370±222 kcal daily, significantly lower than the FAO/WHO recommended daily intake of 1807±310 kcal. Measured RMR was 1001±119, significantly higher than predicted 952±78 kcal daily. The energy cost of physical activity was only 231±131 kcal. An index of activity, assessed as the difference between measured and predicted TEE, was correlated positively with sport and leisure activity during the past year assessed by questionnaire. It is concluded that most of the difference between measured and predicted TEE seems to be due to less physical activity than expected and that this may be related to increased television viewing.
KW  - children
KW  - energy cost of activities
KW  - energy intake
KW  - energy requirements
KW  - exercise
KW  - physical activity
KW  - resting energy exchange
KW  - television
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hydrolysis of proline dipeptides completely fulfills the proline requirement in a proline-auxotrophic Chinese hamster ovary cell line.
AU  - Emmerson, K. S.
AU  - Phang, J. M.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1993///
VL  - 123
IS  - 5
SP  - 909
EP  - 914
SN  - 0022-3166
AD  - Emmerson, K. S.: J. M. Phang, Laboratory of Nutritional and Molecular Regulation, Division of Cancer Prevention and Control, The National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19931464530.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 147-85-3.  Subject Subsets: Human Nutrition
N2  - Proline and hydroxyproline-containing oligopeptides may be important in protein nutrition because intestinal hydrolases are incapable of recognizing their imido bonds. Peripheral tissues have a cytosolic enzyme prolidase that cleaves dipeptides containing C-terminal proline (X-Pro) or hydroxyproline. The role of dipeptides in intracellular metabolism is uncertain. The study examined the ability of X-Pro to provide proline to the proline-auxotrophic cell line, CHO-K1. The action of prolidase on exogenously supplied Gly-Pro, the most abundant dipeptide product of digestion, provided adequate proline to support normal cell growth of CHO-K1 cells in a dose-dependent manner. The growth curve generated by addition of Gly-Pro to CHO-K1 cells was similar to that due to proline. Two other structurally unrelated X-Pro also supported growth indistinguishably from Gly-Pro. Gly-Hyp was completely ineffective for growth. The ability of X-Pro to sustain cultures of a proline-auxotrophic cell line may be important in elucidating intracellular nutritional and physiological functions for those dipeptides.
KW  - cell cultures
KW  - dipeptides
KW  - growth
KW  - Proline
KW  - Cricetulus barabensis
KW  - hamsters
KW  - Cricetulus
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A summary of the workshop "Alcohol and calories: a matter of balance".
AU  - Lands, W. E. M.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1993///
VL  - 123
IS  - 7
SP  - 1338
EP  - 1341
SN  - 0022-3166
AD  - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rochville, MD 20857, USA.
N1  - Accession Number: 19931466305.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
KW  - alcoholic beverages
KW  - energy intake
KW  - intake
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Alcohol and calories: a matter of balance
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466305&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High fiber diets slow bone turnover in young men but have no effect on efficiency of intestinal calcium absorption.
AU  - O'Brien, K. O.
AU  - Allen, L. H.
AU  - Quatromoni, P.
AU  - Siu-Caldera, M. L.
AU  - Vieira, N. E.
AU  - Perez, A.
AU  - Holick, M. F.
AU  - Yergey, A. L.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1993///
VL  - 123
IS  - 12
SP  - 2122
EP  - 2128
SN  - 0022-3166
AD  - O'Brien, K. O.: National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6C101, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402053.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 7440-70-2, 9002-64-6, 1406-16-2.  Subject Subsets: Human Nutrition
N2  - The effects of a high fibre diet on calcium balance and kinetics and on Ca-regulating hormones were investigated in 7 young men who participated in two 23-day studies. In the low fibre period, diet provided fibre 6.5 g and Ca 530 mg daily. In the high fibre period fibre was increased to 31.3 g and Ca to 586 mg daily by substituting high fibre cereal. Estimated between 7 and 12 days of each period, the high fibre diet significantly lowered the apparent absorption of Ca (from 60.9±23.8 to 37.1±26.5%) and reduced Ca balance, although balance remained positive overall. Fibre had no effect on serum total or ultrafiltrable Ca, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D or parathyroid hormone concentrations estimated after 1, 7, 12 and 20 days. Ca kinetics was studied between 17 and 23 days by administering oral 44Ca and intravenous 42Ca to fasting subjects. Fractional absorption of Ca in the fasting state was unaffected by fibre. However, during the high fibre period, men had significantly lower bone accretion, resorption and turnover rates, and Ca flow to bone from the exchangeable pool than during the low fibre period. It is concluded that the fibre-induced reduction in Ca absorption reduced bone Ca turnover but did not increase the efficiency of intestinal absorption.
KW  - bones
KW  - calcium
KW  - calcium absorption
KW  - fibre
KW  - hormones
KW  - intake
KW  - men
KW  - metabolism
KW  - parathyrin
KW  - vitamin D
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fiber
KW  - parathyroid hormone
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402053&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutritional epidemiology of cervical neoplasia.
AU  - Potischman, N.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1993///
VL  - 123
IS  - 2/2
SP  - 424
EP  - 429
SN  - 0022-3166
AD  - Potischman, N.: Environmental Studies Section, Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931464487.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Human Nutrition
N2  - There seems to be a natural progression of some preinvasive cervical lesions to more advanced lesions. Although research has evaluated the associations between nutrients and particular preinvasive lesions or invasive disease, little work has been done to compare results across the spectrum of lesions in the progression to invasive disease. This review compiles studies that have evaluated the relation between nutrients and cervical neoplasia and evaluates the general consistency of the literature across stage of disease. Preformed vitamin A does not seem to be related to risk of any preinvasive or invasive lesions, whereas vitamin C has been associated with a reduced risk of dysplasia, in situ cancer, and invasive disease, particularly among smokers. There was evidence of reduced risks associated with various carotenoids and vitamin E at all stages of the disease process, although these studies were inconsistent and further work is needed. Folate was the only nutrient that seemed to be protective for dysplastic lesions and not related to risk of in situ or invasive disease. Red blood cell folate was a better predictor of dysplasia than were serum or dietary folate, and further investigation using this marker of folate status is warranted. Research is needed across a spectrum of lesions within one study, with particular attention to interactions between nutrients and other risk factors for disease.
KW  - Carcinoma
KW  - cervix
KW  - diet
KW  - Neoplasms
KW  - reviews
KW  - Man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunohistochemical localization of laminin in the hearts of patients with chronic chagasic cardiomyopathy: relationship to thickening of basement membranes.
AU  - Sanchez, J. A.
AU  - Milei, J.
AU  - Yu, Z. X.
AU  - Storino, R.
AU  - Wenthold, R., Jr.
AU  - Ferrans, V. J.
JO  - American Heart Journal
JF  - American Heart Journal
Y1  - 1993///
VL  - 126
IS  - 6
SP  - 1392
EP  - 1401
SN  - 0002-8703
AD  - Sanchez, J. A.: Pathology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950802319.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Protozoology
N2  - The histological and ultrastructural appearance of endomyocardial tissue from 10 patients with chronic cardiomyopathy secondary to Trypanosoma cruzi was evaluated. Examination revealed marked thickening of the basement membranes of endothelial cells, myocytes and vascular muscle cells. Immunohistochemical analysis demonstrated a positive reaction for laminin in the thickened membranes. It is suggested that the cause of such thickening may result from an immunological response to tissue injury leading to some of the basement membrane components developing antigenicity. Other possibilities include myocardial fibrosis with the development of new connective tissue components, or to an immunological reaction resulting from the presence of a laminin-like molecule on the surface membrane of T. cruzi amastigotes and promastigotes.
KW  - cardiomyopathy
KW  - cell membranes
KW  - Chagas' disease
KW  - electron microscopy
KW  - fibrosis
KW  - heart
KW  - heart diseases
KW  - human diseases
KW  - immunohistochemistry
KW  - immunopathology
KW  - laminins
KW  - parasites
KW  - pathology
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Protozoa
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - coronary diseases
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets.
AU  - Boschero, A. C.
AU  - Crepaldi, S. C.
AU  - Carneiro, E. M.
AU  - Delattre, E.
AU  - Atwater, I.
JO  - Endocrinology (Philadelphia)
JF  - Endocrinology (Philadelphia)
Y1  - 1993///
VL  - 133
IS  - 2
SP  - 515
EP  - 520
SN  - 0013-7227
AD  - Boschero, A. C.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930463423.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 7440-70-2, 50-99-7, 9004-10-8, 9002-62-4.  Subject Subsets: Dairy Science; Human Nutrition
N2  - The effects of prolactin (PRL) treatment on insulin content and secretion, and 86Rb and 45Ca fluxes from neonatal rat islets maintained in culture for 7-9 days were studied. PRL treatment enhanced islet insulin content by 40% and enhanced early insulin secretion evoked by 16.7 mM glucose. Insulin release stimulated by oxotremorine-M, a muscarinic agonist, in the presence of glucose (8.3 or 16.7 mM) was unchanged by PRL treatment. However, PRL treatment potentiated phorbol 12,13-dibutyrate-stimulated insulin secretion in the presence of the above glucose concentrations. PRL treatment potentiated the reduction in 86Rb efflux by glucose or tolbutamide and enhanced the increase in 86Rb efflux evoked by diazoxide. PRL treatment slightly potentiated the increment in 45Ca uptake induced by high concentrations of K+, but failed to affect the increment evoked by 16.7 mM glucose. Since glucose-induced 45Ca uptake was not affected by PRL, it is suggested that the enhancement in 1st-phase insulin secretion evoked by glucose in the PRL-treated islets occurs at a step in the secretory process that may involve protein kinase-C. These data further support observations that PRL treatment increases islet sensitivity to glucose.
KW  - calcium
KW  - cell cultures
KW  - glucose
KW  - insulin
KW  - insulin secretion
KW  - pancreas
KW  - pancreas islets
KW  - prolactin
KW  - release
KW  - uptake
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dextrose
KW  - insulin release
KW  - lactogenic hormone
KW  - mammotropin
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of dietary phosphorus-dependent duodenal calcium uptake in vitamin D-deficient chicks.
AU  - Liang, C. T.
AU  - Barnes, J.
AU  - Sacktor, B.
AU  - Balakir, R. A.
JO  - Journal of Membrane Biology
JF  - Journal of Membrane Biology
Y1  - 1993///
VL  - 134
IS  - 3
SP  - 189
EP  - 196
SN  - 0022-2631
AD  - Liang, C. T.: National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19961400318.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 7440-70-2, 1406-16-2.  Subject Subsets: Human Nutrition; Animal Nutrition
N2  - The effect of dietary phosphorus on intestinal calcium uptake was examined in duodenal cells isolated from vitamin D-deficient chicks. Cells from chicks on a high P diet accumulated Ca at a rate 38% higher than cells from chicks on a normal P diet. Diet high in Ca did not affect Ca absorption in duodenal cells. The dietary P effect on Ca absorption was specific. Uptake of α-methyl glucoside was not altered. Increase in Ca absorption by a high P diet was not due to change in cellular energy metabolism nor to the content of P in cells. Kinetically, a high P diet decreased the Vmax of Ca uptake; the affinity for Ca was unaffected. The effectiveness of dietary P to enhance the intestinal Ca uptake was also observed in brush border membranes vesicles. The increase in Ca uptake was not due to an alteration in membrane binding capacity nor to Ca efflux from vesicles. The phospholipid content in isolated brush border membranes was also examined. The content of phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine was not altered by the high P diet. The results suggest that the vitamin D-independent and dietary P-dependent effect on intestinal Ca absorption was primarily due to a change in the Ca flux at the luminal side of the cells.
KW  - calcium
KW  - chicks
KW  - deficiency
KW  - duodenum
KW  - intestinal absorption
KW  - minerals
KW  - vitamin D
KW  - vitamins
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400318&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cigarette smoking and the risk of endometrial cancer.
AU  - Brinton, L. A.
AU  - Barrett, R. J.
AU  - Berman, M. L.
AU  - Mortel, R.
AU  - Twiggs, L. B.
AU  - Wilbanks, G. D.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 137
IS  - 3
SP  - 281
EP  - 291
SN  - 0002-9262
AD  - Brinton, L. A.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932021437.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Public Health
N2  - From a study of 405 cases and 297 controls the authors conclude that the results "support the notion that smoking reduces the risk of endometrial cancer through extraovarian endogenous hormonal mechanims. Further studies, [they argue], are needed to clarify why reduced risks are most pronounced among postmenopausal women and those currently exposed to cigarette smoke." However, none of the relations they observed attained statistical significance. D.W. FitzSimons
KW  - endometrium
KW  - female genitalia
KW  - genitalia
KW  - neoplasms
KW  - risk factors
KW  - smoking
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - America (North)
KW  - cancer sites
KW  - cancers
KW  - endometrial area
KW  - female genital system
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021437&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A cohort study of alcohol consumption and risk of breast cancer.
AU  - Friedenreich, C. M.
AU  - Howe, G. R.
AU  - Miller, A. B.
AU  - Jain, M. G.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 137
IS  - 5
SP  - 512
EP  - 520
SN  - 0002-9262
AD  - Friedenreich, C. M.: National Cancer Institute of Canada Epidemiology Unit, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
N1  - Accession Number: 19951404082.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - The association between alcohol consumption and breast cancer risk was examined in 519 newly incident, histologically confirmed cases of breast cancer diagnosed between 1982 and 1987 within a cohort of 56 837 women enrolled in the Canadian National Breast Screening Study. These women had completed a self-administered food frequency questionnaire including alcohol consumption at enrollment into the study prior to their breast cancer diagnosis. For the total cohort, only a weak association between total alcohol consumption and breast cancer risk was observed, the adjusted relative risk for those drinking ≥30 g/day being 1.22 (95% confidence interval (CI) 0.78 to 1.90) compared with nondrinkers. There is some evidence for a positive association in women who were premenopausal at the time of enrollment for whom there was a monotonic increase in risk with increasing alcohol intake. Compared with nondrinkers, the adjusted relative risk for alcohol consumption of alcohol between 0 and &lt;10 g daily was 1.11 (95% CI 0.71 to 1.71), between 10 and &lt;20 g was 1.37 (95% CI 0.79 to 2.36), between 20 and &lt;30 g was 1.51 (95% CI 0.80 to 2.86) and &gt;30 g was 1.86 (95% CI 0.96 to 3.66; P=0.07). These findings contrasted with the results for postmenopausal women where there appeared to be no evidence of any relation. The association in premenopausal women is generally reasonably consistent with that of other studies that have found positive associations with alcohol intake.
KW  - alcoholic beverages
KW  - breast cancer
KW  - intake
KW  - mammary gland neoplasms
KW  - menopause
KW  - neoplasms
KW  - risk
KW  - risk factors
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - mammary tumour
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary patterns associated with a low-fat diet in the National Health Examination follow-up study: identification of potential confounders for epidemiologic analyses.
AU  - Ursin, G.
AU  - Ziegler, R. G.
AU  - Subar, A. F.
AU  - Graubard, B. I.
AU  - Haile, R. W.
AU  - Hoover, R.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 137
IS  - 8
SP  - 916
EP  - 927
SN  - 0002-9262
AD  - Ursin, G.: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951407789.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - To identify systematically the nutrient and food group intakes associated with a low-fat diet, detailed dietary information collected from 10 306 individuals 32-86 years old in the 1982-1984 National Health Epidemiologic Follow-up Study was used. Intakes of vitamin C and percentages of energy from carbohydrates, dietary fibre, poultry, low-fat dairy products, fruits, vegetables, cereals and whole grains were markedly higher, while intakes of protein, total fat, saturated fat, oleic and linoleic acids, cholesterol, sodium, all red meats, high-fat dairy products, eggs, nuts, white bread, fried potatoes, desserts, fats and oils were much lower in the quartile with the lowest percentage of energy from fat. These dietary patterns associated with a low-fat diet were essentially constant across strata of age, sex, race and socioeconomic status. This study suggests that individuals on a low-fat diet substitute certain carbohydrate-rich foods such as fruits and vegetable for fat. Given those associations between low-fat diets and other dietary factors independently associated with certain cancers, these dietary factors should be considered potential confounders in studies of dietary fat and these cancers.
KW  - carcinoma
KW  - diet studies
KW  - epidemiology
KW  - fats
KW  - intake
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Overweight, weight loss, and risk of coronary heart disease in older women: the NHANES I Epidemiologic Follow-up Study.
AU  - Harris, T. B.
AU  - Ballard-Barbasch, R.
AU  - Madans, J.
AU  - Makuc, D. M.
AU  - Feldman, J. J.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 137
IS  - 12
SP  - 1318
EP  - 1327
SN  - 0002-9262
AD  - Harris, T. B.: National Institute on Aging, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951405979.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Human Nutrition
N2  - Measured body weight for 1259 white women aged 65-74 years from the Epidemiologic Follow-up Study of the First National Health and Nutrition Examination Survey was used to examine the effect of overweight on coronary heart disease incidence (mean length of follow-up 14 years). Reported lifetime maximum body weight was also used to examine the effect of weight loss on this association. Women with a Quetelet index (weight (kg)/height (m)²) of 29 or more showed an increased risk of coronary heart disease (relative risk (RR) = 1.5, 95% confidence interval (CI) 1.1-2.1) after adjustment for age and smoking in comparison with those with a Quetelet index of less than 21, while women with a Quetelet index of 23-24 had a lower risk of coronary heart disease (RR = 0.6, 95% CI 0.4-0.9). However, the pattern of risk associated with measured weight was modified by weight loss. Among heavier women whose weight was relatively stable, those with a Quetelet index of 29 or more had an increased risk of heart disease (RR = 2.7, 95% CI 1.7-4.4). Among those with greater weight loss, the relation between Quetelet index and risk of coronary heart disease was J-shaped. Overweight is an independent risk factor for coronary heart disease in older women, a finding strengthened after previous weight loss is accounted for. Reasons for the unexpected increase in risk of coronary heart disease in thinner women who lost weight are unclear, and further investigation is warranted.
KW  - aging
KW  - body weight
KW  - diet studies
KW  - heart diseases
KW  - old age
KW  - weight reduction
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - ageing
KW  - coronary diseases
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interpretation of energy adjustment models for nutritional epidemiology.
AU  - Kipnis, V.
AU  - Freedman, L. S.
AU  - Brown, C. C.
AU  - Hartman, A.
AU  - Schatzkin, A.
AU  - Wacholder, S.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 137
IS  - 12
SP  - 1376
EP  - 1380
SN  - 0002-9262
AD  - Kipnis, V.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951405981.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Subject Subsets: Human Nutrition
N2  - The interpretation of 3 alternative energy adjustment models for nutritional epidemiology is discussed. It is shown that 4 different effects are addressed by these models: adding nutrient N, substituting nutrient N for "other" nutrients, adding "other" nutrients, and adding N and "other" nutrients in a specific ratio. Each of these effects may be estimated from any of the 3 models. The relative standard errors for the 4 estimated effects are also provided.
KW  - diet study techniques
KW  - epidemiology
KW  - mathematical models
KW  - methodology
KW  - nutrition
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - methods
KW  - Diet Studies (VV110) 
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for cancers of the nasal cavity and paranasal sinuses among white men in the United States.
AU  - Zheng, W.
AU  - McLaughlin, J. K.
AU  - Chow, W. H.
AU  - Chien, H. T. C.
AU  - Blot, W. J.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 138
IS  - 11
SP  - 965
EP  - 972
SN  - 0002-9262
AD  - Zheng, W.: (J.K. McLaughlin) National Cancer Institute, 6130 Executive Blvd., EPN 415, Rockville, MD 20852, USA.
N1  - Accession Number: 19942028169.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A case-control analysis of cancer of the nasal cavity and sinuses was performed using data from the 1986 National Mortality Followback Survey. Data on cigarette smoking, alcohol consumption, usual diet, and other factors from 147 white men who died from nasal cancer and from 449 controls who died from other causes were compared. Cigarette smoking was related to an increased risk of nasal cancer, with a doubling of risk among heavy or long-term smokers and a reduction in risk among long-term quitters. Among nonsmokers, having a spouse who smoked was associated with a significantly elevated risk of nasal cancer. After adjustment for smoking, a significant dose-response relation was also noted between alcohol drinking and risk of nasal cancer. High consumption of salted/smoked foods was associated with elevated risk, and risk tended to decrease with increasing intake of vegetables. Associations were more pronounced for cigarette smoking and certain dietary items when the analysis was restricted to maxillary sinus cancer. The study confirms that cigarette smoking is a risk factor for nasal cancer, and provides further evidence that dietary factors may play a role in the aetiology of this malignancy.AS
KW  - neoplasms
KW  - nose
KW  - paranasal sinuses
KW  - risk factors
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028169&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Association of delayed conception with caffeine consumption.
AU  - Hatch, E. E.
AU  - Bracken, M. B.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1993///
VL  - 138
IS  - 12
SP  - 1082
EP  - 1092
SN  - 0002-9262
AD  - Hatch, E. E.: Epidemiology and Biostatistic Program, Division of Cancer Etiology, National Cancer Institute, EPN 408, 6130 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19942028174.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 58-08-2.  Subject Subsets: Human Nutrition; Public Health
N2  - This cross-sectional study investigated the relation between intake of caffeine-containing beverages and time to conception in a population of 1909 married women in New Haven, Connecticut, between May 12, 1980 and March 12, 1982. Women were interviewed shortly after the first prenatal visit regarding the length of time taken to conceive the index pregnancy, consumption of caffeine during pregnancy, and other exposures occurring prior to and during pregnancy. In logistic regression analyses, intake of caffeine from coffee, tea, and caffeinated soft drinks was associated with an increased risk of a delay of conception of 1 year or more. Compared with no caffeine use, consumption of 1-150 mg/day of caffeine resulted in an odds ratio for delayed conception of 1.39 (95% confidence interval (CI) 0.90-2.13), consumption of 151-300 mg/day of caffeine was associated with an odds ratio of 1.88 (95% CI 1.13-3.11), and that of over 300 mg/day (the equivalent of approximately three cups of coffee) resulted in an odds ratio of 2.24 (95% CI 1.06-4.73), after controlling for last method of birth control used, parity, and number of cigarettes per day. When the risk of conception for each cycle was examined using a discrete analogue of the Cox proportional hazards model, women who reported drinking over 300 mg/day of caffeine had a 27% lower chance of conceiving for each cycle, and those who reported drinking less than 300 mg/day had a 10% reduction in per cycle conception rates compared with women who consumed no caffeine. Risks for coffee, tea, and colas were examined simultaneously in logistic models and were found not to improve the fit of a model that contained a variable for total caffeine intake from all sources. AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;This cross-sectional study investigated the relation between intake of caffeine-containing beverages and time to conception in a population of 1909 married women in New Haven, Connecticut, USA between May 12, 1980 and March 12, 1982. Women were interviewed shortly after the first prenatal visit regarding the length of time taken to conceive the index pregnancy, consumption of caffeine during pregnancy, and other exposures occurring prior to and during pregnancy. In logistic regression analyses, intake of caffeine from coffee, tea and caffeinated soft drinks was associated with an increased risk of a delay of conception of 1 year or more. Compared with no caffeine use, consumption of 1-150 mg/day of caffeine resulted in an odds ratio for delayed conception of 1.39 (95% confidence interval (CI) 0.90-2.13), consumption of 151-300 mg/day of caffeine was associated with an odds ratio of 1.88 (95% CI 1.13-3.11), and that of over 300 mg/day (the equivalent of approximately 3 cups of coffee) resulted in an odds ratio of 2.24 (95% CI 1.06-4.73), after controlling for last method of birth control used, parity and number of cigarettes per day. When the risk of conception for each cycle was examined using a discrete analogue of the Cox proportional hazards model, women who reported drinking over 300 mg/day of caffeine had a 27% lower chance of conceiving for each cycle, and those who reported drinking less than 300 mg/day had a 10% reduction in per cycle conception rates compared with women who consumed no caffeine. Risks for coffee, tea and colas were examined simultaneously in logistic models and were found not to improve the fit of a model that contained a variable for total caffeine intake from all sources.
KW  - Caffeine
KW  - coffee
KW  - conception
KW  - effects
KW  - female fertility
KW  - female infertility
KW  - fertility
KW  - health
KW  - tea
KW  - women
KW  - Connecticut
KW  - North America
KW  - USA
KW  - Camellia sinensis
KW  - Coffea
KW  - man
KW  - Camellia
KW  - Theaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Rubiaceae
KW  - Rubiales
KW  - Gentianales
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Human Reproduction and Development (VV060) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028174&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variation in the size of the ospA-containing linear plasmid, but not the linear chromosome, among the three Borrelia species associated with Lyme disease.
AU  - Samuels, D. S.
AU  - Marconi, R. T.
AU  - Garon, C. F.
JO  - Journal of General Microbiology
JF  - Journal of General Microbiology
Y1  - 1993///
VL  - 139
IS  - 10
SP  - 2445
EP  - 2449
SN  - 0022-1287
AD  - Samuels, D. S.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930518591.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - The aetiological agents of Lyme disease form a phylogenetically heterologous group, composed of 3 species, B. burgdorferi, B. garinii and group VS461 [B. afzelii]. The sizes of the linear plasmid that carried the genes encoding the major outer-surface proteins OspA and OspB, as well as the size and structure of the chromosome, were compared among the Lyme disease spirochaetes. Differences were found in the sizes of the ospA-containing plasmids, but not the linear chromosome among the 3 species. The ospA-containing plasmid size of 50 kb in B. burgdorferi isolates is significantly smaller than the size of 55 kb in B. garinii isolates and 56 kb in group VS461 isolates. The chromosome was found to be linear in all 3 Borrelia species, but not significantly different in size.
KW  - biotechnology
KW  - chromosomes
KW  - DNA
KW  - genes
KW  - molecular genetics
KW  - plasmids
KW  - proteins
KW  - Borrelia
KW  - Borrelia afzelii
KW  - Borrelia burgdorferi
KW  - Borrelia garinii
KW  - Spirochaetaceae
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Borrelia
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - outer-surface
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518591&site=ehost-live&scope=site
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TY  - JOUR
T1  - Schistosomiasis: infection versus disease and hypersensitivity versus immunity.
AU  - Cheever, A. W.
JO  - American Journal of Pathology
JF  - American Journal of Pathology
Y1  - 1993///
VL  - 142
IS  - 3
SP  - 699
EP  - 702
SN  - 0002-9440
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803385.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Hepatic pathology in schistosomiasis is secondary to an immunologically mediated reaction to the ova. Infected persons who develop periportal fibrosis lack regulatory idiotypes present in individuals without such fibrosis. This article discusses current concepts of the pathogenesis of hepatic pathology in schistosomiasis with particular reference to the development of pipestem fibrosis in animal models. It then considers the host immune response to schistosome ova and the development of hepatic granulomata. Although prevention and control of schistosomal disease is usually based on reduction of the worm burden by chemotherapy, infection intensity might be more efficiently reduced by vaccination. With this in mind, immunity and the prospect of an anti-schistosomal vaccine are discussed.
KW  - fibrosis
KW  - granuloma
KW  - helminths
KW  - human diseases
KW  - hypersensitivity
KW  - immune response
KW  - immunity
KW  - immunization
KW  - immunology
KW  - immunopathology
KW  - inactivated vaccines
KW  - liver diseases
KW  - ova
KW  - parasites
KW  - pathology
KW  - reviews
KW  - Schistosomiasis
KW  - man
KW  - Schistosoma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - allergic responses
KW  - bilharzia
KW  - bilharziasis
KW  - hypersensitiveness
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - killed vaccines
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803385&site=ehost-live&scope=site
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TY  - JOUR
T1  - CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition.
AU  - Denkers, E. Y.
AU  - Sher, A.
AU  - Gazzinelli, R. T.
JO  - Research in Immunology
JF  - Research in Immunology
Y1  - 1993///
VL  - 144
IS  - 1
SP  - 51
EP  - 57
SN  - 0923-2494
AD  - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930806005.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - The role of CD8+ T cells in immunity to Toxoplasma gondii is reviewed under the headings: role of interferon-γ; CD8+ cytolytic activity against infected host cells; hypotheses to explain dual requirement for interferon-γ and CD8+ cells; alternate entranceways into the class-I-restricted pathway of presentation.
KW  - Cytokines
KW  - Human diseases
KW  - immune response
KW  - immunology
KW  - Interferon
KW  - Major histocompatibility complex
KW  - parasites
KW  - Reviews
KW  - T lymphocytes
KW  - Apicomplexa
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - histocompatibility complex
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulatory and immunopathological roles of IL4 in experimental schistosomiasis.
AU  - Oswald, I. P.
AU  - Wynn, T. A.
AU  - Williams, M. E.
AU  - Eltoum, I.
AU  - Cheever, A. W.
AU  - James, S. L.
AU  - Sher, A.
JO  - Research in Immunology
JF  - Research in Immunology
Y1  - 1993///
VL  - 144
IS  - 8
SP  - 643
EP  - 648
SN  - 0923-2494
AD  - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950804316.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 207137-56-2.  Subject Subsets: Helminthology
N2  - The role of interleukin (IL)-4 during Schistosoma infection is reviewed, with reference to cytokine production during schistosomiasis, cellular sources of IL-4 in schistosome-infected animals, the role of IL-4 in Th2 cell response maturation, the immunopathological function of IL-4, and the down-regulatory influence of IL-4 on macrophage and endothelial cell effector functions. It is concluded that IL-4 has 3 major roles in schistosomiasis: it influences the development of the Th2 response; it participates in egg-induced pathology; and it is involved in the downregulation of cell-mediated immunity. Some of these functions appear to be beneficial to the parasite.
KW  - cytokines
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - interleukin 4
KW  - parasites
KW  - reviews
KW  - schistosomiasis
KW  - Digenea
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804316&site=ehost-live&scope=site
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TY  - JOUR
T1  - Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes.
AU  - Denkers, E. Y.
AU  - Gazzinelli, R. T.
AU  - Hieny, S.
AU  - Caspar, P.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1993///
VL  - 150
IS  - 2
SP  - 517
EP  - 526
SN  - 0022-1767
AD  - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930804388.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Protozoology
N2  - It was shown that class I-transfected L cells differ from bone marrow macrophages (BMMØ) in that although both cell types are recognized cytolytic T lymphocytes after infection, only BMMØ are killed after sensitization with soluble tachyzoite extract. Gel filtration studies indicated that the T. gondii antigen responsible for sensitization of BMMØ are macromolecules with a MW ≥12 000. In contrast, peptides derived by tryptic digestion of this material were found to sensitize both transfected L cells and BMMØ. Although exogenous β2-microglobin markedly enhanced peptide sensitization of BMMØ, no such effect was observed using the macromolecular preparation. A requirement for cellular internalization in the processing by BMMØ of soluble antigen for class I-restricted recognition is suggested. In related experiments, infected and antigen-sensitized BMMØ were found to express cross-reactive T. gondii epitopes, as determined by cold target inhibition studies. Supernatant derived by 100 000 g centrifugation of tachyzoite extract had potent sensitizing activity, and after anion exchange chromatography most of the activity was associated with a single fraction. The p30 antigen was not detected by immunoblot analysis in the biologically active supernatant and chromatographic fractions.
KW  - Antibodies
KW  - Antigens
KW  - Bone marrow
KW  - Human diseases
KW  - immune response
KW  - Laboratory animals
KW  - Macrophages
KW  - parasites
KW  - Polypeptides
KW  - T lymphocytes
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - protozoa
KW  - Rodents
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Toxoplasma gondii induces a T-independent IFN-γ response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-α.
AU  - Sher, A.
AU  - Oswald, I. P.
AU  - Hieny, S.
AU  - Gazzinelli, R. T.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1993///
VL  - 150
IS  - 9
SP  - 3982
EP  - 3989
SN  - 0022-1767
AD  - Sher, A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804527.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9008-11-1, 308079-78-9.  Subject Subsets: Protozoology
N2  - Spleen cells from scid mice produce high levels of IFN-γ when exposed to either live tachyzoites of Toxoplasma gondii or a soluble parasite extract. Small numbers of parasites are sufficient to stimulate this response, which is also induced by cell-free supernatants of cultured tachyzoites. The parasite molecules responsible for triggering IFN-γ production are heat-labile but resistant to freezing and thawing. Depletion of NK cells or adherent cells from the splenocyte population abolishes the response. Moreover, cultured bone marrow-derived NK cells are stimulated by Toxoplasma to produce IFN-γ, but only when supplemented with adherent peritoneal washout or thioglycollate-induced exudate cells. Supernatants of macrophages preincubated with T. gondii extract also induce IFN-γ synthesis by cultured NK cells. Addition of neutralizing MAb against TNF-α abolishes the IFN-γ response of scid spleen cells exposed to the parasite or of NK cells incubated with supernatants of adherent cells stimulated with T. gondii extract. Moreover, splenic adherent cells produce low levels of TNF-α in response to the parasite. Nevertheless, TNF-α alone is not sufficient to trigger IFN-γ production from purified NK cell populations. These findings provide the first example of the stimulation of T-independent IFN-γ production by a protozoan. The ability of T. gondii to trigger this pathway may underlie its induction of strong IFN-γ-dependent nonspecific and specific cell-mediated immunity.
KW  - cytokines
KW  - experimental infections
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - laboratory animals
KW  - natural killer cells
KW  - parasites
KW  - tumour necrosis factor
KW  - Apicomplexa
KW  - mice
KW  - Muridae
KW  - protozoa
KW  - rodents
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - cachectin
KW  - cachexin
KW  - immunity reactions
KW  - immunological reactions
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Regulation of IL-5 in onchocerciasis. A critical role for IL-2.
AU  - Steel, C.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1993///
VL  - 150
IS  - 12
SP  - 5511
EP  - 5518
SN  - 0022-1767
AD  - Steel, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930808529.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2.  Subject Subsets: Helminthology
N2  - The cytokine profiles of peripheral blood mononuclear cells (PBMC) obtained from putatively immune individuals from an Onchocerca-endemic area of Guatemala were compared to those from Onchocerca volvulus infected individuals. The immune individuals had significantly higher levels of both interleukin-2 (IL-2) and IL-5 in response to parasite antigen than did individuals with active infection and there was a direct correlation between the production of IL-2 and IL-5. To examine the mechanism underlying the possible association between these 2 cytokines in patients infected with Onchocerca volvulus, reverse transcription and polymerase chain reaction were used to measure IL-5 mRNA. In response to recombinant IL-2, IL-5 RNA appeared 3 h after stimulation of patient PBMC, reaching a peak after 24 h. This response was inhibited with neutralizing antibodies to IL-2. IL-2 was unable to induce mRNA expression for IL-4, γ-interferon, IL-10 or granulocyte-macrophage-CSF. IL-5 mRNA expression was measured in PBMC stimulated with parasite antigen and was up-regulated in all patients (peaking at 72 h) independently of proliferation to antigen. This up-regulation was specifically inhibited by neutralizing anti-IL-2 antibodies. The primary source of IL-5 mRNA was determined to be CD4+ T cells. The findings suggest that IL-2 production is required to induce IL-5 and further implicates IL-5 as a possible mediator in onchocerciasis.
KW  - cytokines
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - interleukin 10
KW  - interleukin 2
KW  - interleukin 5
KW  - parasites
KW  - T lymphocytes
KW  - Central America
KW  - Guatemala
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - America
KW  - CACM
KW  - Central America
KW  - Developing Countries
KW  - Latin America
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni.
AU  - Wynn, T. A.
AU  - Eltoum, I.
AU  - Cheever, A. W.
AU  - Lewis, F. A.
AU  - Gause, W. C.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1993///
VL  - 151
IS  - 3
SP  - 1430
EP  - 1440
SN  - 0022-1767
AD  - Wynn, T. A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 4/126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930807929.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Helminthology
N2  - Cytokine mRNA expression in lung tissue of C3H/HeN mice infected with 25 cercariae of Schistosoma mansoni (NMRI strain) was analyzed using a reverse transcriptase-polymerase chain reaction. Temporal analysis of mRNA expression in lung tissue containing synchronized granulomas demonstrated a Th0-like pattern of lymphokine expression. Interferon-(IFN)-γ, interleukin-(IL)-1β, and IL-6 were the primary cytokines induced, by day 1, in developing lung granulomas initiated by iv ovum injection. The changes were followed by increases in expression of IL-2, IL-4, and IL-10 mRNA on day 3 and TNF-α and IL-5 mRNA on day 6. Nearly all cytokine mRNA reached maximal levels by day 6, which preceded the peak in granuloma size seen on day 14. In vivo treatment of ovum-injected mice with either anti-IL-2 or anti-IL-4 antibodies significantly diminished the size of circumoval granulomas in the lungs. Both groups of antibody-treated animals displayed a marked reduction in IL-4 as well as IL-5 mRNA expression, although IFN-γ and IL-2 mRNA levels were unchanged or slightly increased. The findings confirm previous observations suggesting a role for IL-2 in ovum-induced pathology via the generation of Th2-associated responses, and also indicate a primary function for IL-4 in granuloma formation. Analysis of responses after injection of ova into C3H nude mice demonstrated that only the Th2 cytokines IL-4 and IL-5 are exclusively dependent on T cells for their induction. The data suggest that Th2 cells producing IL-4 play a major role in ovum granuloma formation, and that the induction and ultimate down-modulation of Th2-like responses may be influenced by non-T-cell-derived cytokines.
KW  - cytokines
KW  - developmental stages
KW  - experimental infections
KW  - granuloma
KW  - helminths
KW  - immune response
KW  - laboratory animals
KW  - parasites
KW  - T lymphocytes
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - growth phase
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807929&site=ehost-live&scope=site
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DB  - lhh
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TY  - JOUR
T1  - Preferential Vβ usage by cytotoxic T cells cross-reactive between two epitopes of HIV-1 gp160 and degenerate in class I MHC restriction.
AU  - Shirai, M.
AU  - Vacchio, M. S.
AU  - Hodes, R. J.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology
JF  - Journal of Immunology
Y1  - 1993///
VL  - 151
IS  - 4
SP  - 2283
EP  - 2295
AD  - Shirai, M.: (J.A. Berzofsky) Molecular Immunogenesis & Vaccine Research Section, Metabolism Branch, Building 10, Room 6B-12, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004687.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref.
KW  - cellular biology
KW  - cytotoxic T lymphocytes
KW  - envelope glycoproteins
KW  - Epitopes
KW  - HIV infections
KW  - Immunology
KW  - phenotypes
KW  - T lymphocytes
KW  - Antigen presentation
KW  - antigenic determinants
KW  - cell biology
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004687&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Normal T cell receptor-mediated signaling in T cell lines stably expressing HIV-1 envelope glycoproteins.
AU  - Tani, Y.
AU  - Tian, H.
AU  - Lane, H. C.
AU  - Cohen, D. I.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1993///
VL  - 151
IS  - 12
SP  - 7337
EP  - 7348
SN  - 0022-1767
AD  - Tani, Y.: (D.I. Cohen) National Institutes of Health, Building 10, Rm 11B-13, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005172.  Publication Type: Journal Article.  Language: English. 
KW  - human immunodeficiency viruses
KW  - Immunology
KW  - receptors
KW  - T lymphocytes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Env
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Signalling
KW  - T cells
KW  - Tat
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005172&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Summary of the 27th United States-Japan Joint Conference on Cholera and Related Diarrheal diseases.
AU  - Spriggs, D. R.
AU  - Guerrant, R. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 1
SP  - 1
EP  - 6
SN  - 0022-1899
AD  - Spriggs, D. R.: Enteric Diseases Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 3A-06, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932022816.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Subject Subsets: Public Health; Tropical Diseases
N2  - A report of the 27th annual meeting held in Charlottesville, Virginia, USA, on 25-27 September 1991.
KW  - Cholera
KW  - diarrhoea
KW  - cholera and related diarrhoeal diseases
KW  - diarrhea
KW  - scouring
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus (HIV) type 1 strain MN neutralizing antibody in HIV-infected children: correlation with clinical status and prognostic value.
AU  - Robert-Guroff, M.
AU  - Roilides, E.
AU  - et al.
AU  - Muldoon, R. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 3
SP  - 538
EP  - 546
SN  - 0022-1899
AD  - Robert-Guroff, M.: Laboratory of Tumor Cell Biology, Building 37, Room 6A15, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006821.  Publication Type: Journal Article.  Language: English. 
KW  - Antibodies
KW  - Children
KW  - Clinical aspects
KW  - HIV infections
KW  - Immunity
KW  - Immunology
KW  - Prognosis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006821&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Impairment of neutrophil antifungal activity against hyphae of Aspergillus fumigatus in children infected with human immunodeficiency virus.
AU  - Roilides, E.
AU  - Holmes, A.
AU  - Blake, C.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 4
SP  - 905
EP  - 911
SN  - 0022-1899
AD  - Roilides, E.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931214538.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The antifungal activity of neutrophils (PMNL) against hyphae of A. fumigatus in 31 HIV-infected children was assessed. Hyphal damage was unaffected in 15 HIV-infected children with age-adjusted CD4 cell counts ≥25% of the normal median value; it was decreased in 16 with CD4 cell counts &lt;25% (both vs. 20 healthy controls, P=0.001). Incubation with sera from 12 of 14 HIV-infected children but not with the recombinant HIV proteins gp120, gp41 and p24 suppressed antifungal activity of normal PMNL compared with normal serum (P=0.002). Pretreatment of defective PMNL from 5 patients with granulocyte colony-stimulating factor (G-CSF) partially corrected the defect (P=0.002). It is suggested that impaired serum-mediated antifungal activity against Aspergillus hyphae exists in PMNL of HIV-infected patients with low CD4 cell counts and that G-CSF may improve this activity.
KW  - acquired immune deficiency syndrome
KW  - activity
KW  - antifungal agents
KW  - antimicrobial properties
KW  - Aspergillosis
KW  - children
KW  - HIV infections
KW  - immunology
KW  - neutrophils
KW  - Opportunistic infections
KW  - predisposition
KW  - Aspergillus fumigatus
KW  - man
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - AIDS
KW  - anti-microbial properties
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214538&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees.
AU  - Hall, S. L.
AU  - Sarris, C. M.
AU  - Tierney, E. L.
AU  - London, W. T.
AU  - Murphy, B. R.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 4
SP  - 958
EP  - 962
SN  - 0022-1899
AD  - Hall, S. L.: Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932022621.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A live attenuated cold-adapted parainfluenza virus type 3 (PIV-3) vaccine is being developed to prevent the serious lower respiratory tract disease caused by this virus in infants and young children. This cold-passaged mutant (cp45) was evaluated in seronegative chimpanzees and found to be highly attenuated in both the upper and lower respiratory tracts compared to its wild-type parent. Animals immunized with cp45 were also highly resistant to wild-type PIV-3 challenge. Stability of the attenuation phenotype was demonstrated by the administration to 2 additional chimpanzees of an isolate of cp45 obtained after 10 days of replication in a chimpanzee. It was attenuated in both the upper and lower respiratory tracts. The cp45 virus present in the respiratory tract secretions of chimpanzees retained the temperature-sensitive (ts) phenotype, but some loss of ts property was observed in the isolates. These results provide a basis on which to proceed to clinical trials in seronegative human infants and children.AS
KW  - immunization
KW  - live vaccines
KW  - Parainfluenza
KW  - vaccines
KW  - chimpanzees
KW  - Pan
KW  - Pongidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Paramyxovirinae
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - attenuated and cold-adapted
KW  - attenuated vaccines
KW  - immune sensitization
KW  - parainfluenza 3 virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022621&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Racial differences in serum β2-microglobulin in persons with human immunodeficiency virus infection.
AU  - Lucey, D. R.
AU  - McCarthy, W. F.
AU  - Blatt, S. P.
AU  - Melcher, G. P.
AU  - Hendrix, C. W.
T2  - Journal of Infectious Diseases
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 5
SP  - 1259
EP  - 1260
SN  - 0022-1899
AD  - Lucey, D. R.: Experimental Immunology Branch, Bldg 10, Room 4B17, NCI/National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004515.  Publication Type: Correspondence.  Language: English.  Registry Number: 9066-69-7. 
KW  - beta2-microglobulin
KW  - Disease markers
KW  - Ethnic groups
KW  - HIV infections
KW  - Pathology
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004515&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetics of serum and cellular interleukin-5 in posttreatment eosinophilia of patients with lymphatic filariasis.
AU  - Limaye, A. P.
AU  - Ottesen, E. A.
AU  - Kumaraswami, V.
AU  - Abrams, J. S.
AU  - Regunathan, J.
AU  - Vijayasekaran, V.
AU  - Jayaraman, K.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 6
SP  - 1396
EP  - 1400
SN  - 0022-1899
AD  - Limaye, A. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930804959.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 90-89-1, 1642-54-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Peripheral blood eosinophil counts and serum levels and in vitro production of eosinophilopoietic cytokines were assessed before, and at frequent intervals after diethylcarbamazine treatment of Bancroftian filariasis in 15 men from Madras, India. Eosinophil counts peaked at day 7 after the start of treatment (359% ± 118% of pretreatment levels) and declined to pretreatment levels by day 17. Serum interleukin (IL-5), undetectable in 14 patients before treatment, rose sharply but transiently, with peak levels (32 ± 7 pg/ml) 2 days after diethylcarbamazine treatment. Granulocyte-macrophage colony-stimulating factor and IL-3 were not detectable in serum at any time. In vitro mitogen-induced IL-5 levels decreased significantly in 7 of 9 patients 3 days after treatment when serum IL-5 was at near-peak levels. By day 10 IL-5 values increased in 8 of 9 patients compared with treatment values. These data define a temporal relationship between serum IL-5 levels and the subsequent development of eosinophilia and suggest that lymphocytes are the source of IL-5.
KW  - Cytokines
KW  - diethylcarbamazine
KW  - drug therapy
KW  - Eosinophilia
KW  - Eosinophils
KW  - Filariasis
KW  - helminths
KW  - Human diseases
KW  - immune response
KW  - infections
KW  - Interleukins
KW  - parasites
KW  - Asia
KW  - India
KW  - Tamil Nadu
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Wuchereria
KW  - Onchocercidae
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - chemotherapy
KW  - eosinophil leukocytes
KW  - immunity reactions
KW  - immunological reactions
KW  - Madras
KW  - nematodes
KW  - parasitic worms
KW  - posttreatment eosinophilia
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804959&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Salvage trial of trimetrexate-leucovorin for the treatment of cerebral toxoplasmosis in patients with AIDS.
AU  - Masur, H.
AU  - Polis, M. A.
AU  - Tuazon, C. U.
AU  - Ogata-Arakaki, D.
AU  - Kovacs, J. A.
AU  - Katz, D.
AU  - Hilt, D.
AU  - Simmons, T.
AU  - Feuerstein, I.
AU  - Lundgren, B.
AU  - Lane, H. C.
AU  - Chabner, B. A.
AU  - Allegra, C. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 167
IS  - 6
SP  - 1422
EP  - 1426
SN  - 0022-1899
AD  - Masur, H.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930804961.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 58-05-9, 52128-35-5.  Subject Subsets: Protozoology
N2  - The clinical efficacy of trimetrexate, a dihydrofolate reductase inhibitor reported to have potent in vitro antitoxoplasma activity, was associated in 9 sulfonamide-intolerant patients with AIDS and biopsy-proven cerebral toxoplasmosis. The 9 patients were treated for 28-149 days with trimetrexate (30-280 mg/m²/day) plus leucovorin (20-90 mg/m² every 6 h). Radiographic responses were documented in 8 patients, and clinical responses in 5 patients. Despite continued therapy, all patients deteriorated clinically and radiographically within 13-109 days of their initial improvement. Trimetrexate at very high doses for extended periods was not associated with serious toxicity. Trimetrexate alone had dramatic but transient activity in sulfonamide-intolerant patients and thus is not adequate as single-agent therapy for AIDS-associated toxoplasmosis.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Antiprotozoal agents
KW  - Brain
KW  - brain diseases
KW  - clinical aspects
KW  - Drug combinations
KW  - drug therapy
KW  - Efficacy
KW  - FOLINIC ACID
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - Immunocompromised hosts
KW  - Opportunistic infections
KW  - parasites
KW  - toxoplasmosis
KW  - Treatment
KW  - Trimetrexate
KW  - Maryland
KW  - North America
KW  - USA
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - brain disorders
KW  - cerebrum
KW  - chemotherapy
KW  - citrovorum factor
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - leucovorin
KW  - Trimetraxate-leucovorin
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Albendazole in human loiasis: results of a double-blind, placebo-controlled trial.
AU  - Klion, A. D.
AU  - Massougbodji, A.
AU  - Horton, J.
AU  - Ekoué, S.
AU  - Lanmasso, T.
AU  - Ahouissou, N. L.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 1
SP  - 202
EP  - 206
SN  - 0022-1899
AD  - Klion, A. D.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930805488.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 54965-21-8.  Subject Subsets: Helminthology
N2  - To assess the filaricidal activity and clinical safety of albendazole in human loiasis, a double-blind, placebo-controlled study was conducted in an endemic area in Benin, Africa. 23 men with microfilaraemia (100-30 000/ml) were randomly assigned to receive albendazole (200 mg; n = 11) or placebo (n = 12) twice daily for 21 days; 1 patient from each group withdrew from the study. There were no clinical adverse effects and no observed hepatotoxicity, renal toxicity, or haematologic abnormalities attributable to the drug. In the albendazole group, microfilarial levels began to decrease at day 14 after treatment and by 6 months had fallen to a geometric mean of 20% of pretreatment levels (vs. 84.8% in the placebo group). Blood eosinophil levels and anti-filarial IgG and IgG4 also fell significantly in response to albendazole. Taken together, these data suggest that albendazole has a primary (possibly embryotoxic) effect on the adult parasite, resulting in a slow decrease in microfilaraemia.
KW  - Albendazole
KW  - Anthelmintics
KW  - drug therapy
KW  - Filariasis
KW  - helminths
KW  - Human diseases
KW  - Loiasis
KW  - parasites
KW  - Africa
KW  - Benin
KW  - Loa loa
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - ACP Countries
KW  - Francophone Africa
KW  - Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - African eyeworm
KW  - chemotherapy
KW  - Dahomey
KW  - loaosis
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930805488&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice.
AU  - Taller, A. M.
AU  - Xiao, S. Y.
AU  - et al.
AU  - Godec, M. S. (
AU  - Asher, D. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 3
SP  - 750
EP  - 753
SN  - 0022-1899
AD  - Taller, A. M.: (D.M. Asher) National Institutes of Health, Bldg. 36, Rm. 5B21, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942025542.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Belgrade virus is a recently described hantavirus that causes severe hemorrhagic fever with renal syndrome (HFRS) in people living in various parts of the Balkan Peninsula. Nucleotide sequencing of the G2-encoding region in the medium (M) segment of the viral genome, reverse transcribed and amplified by the polymerase chain reaction, revealed the Belgrade virus to be substantially different from Hantaan virus and other major serotypes of hantavirus but identical to Dobrava virus, a virus isolated from a field mouse (Apodemus flavicollis) in Slovenia. Belgrade virus may be an important cause of HFRS in the Balkan Peninsula, extending north toward the Alps. It poses a special danger to humans who have close contact with field rodents. AS
KW  - characterization
KW  - Belgrade virus
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A pilot study of sequential therapy with zidovudine plus acyclovir, dideoxyinosine, and dideoxycytidine in patients with severe human immunodeficiency virus infection.
AU  - Nguyen, B. Y. T.
AU  - Shay, L. E.
AU  - et al.
AU  - Wyvill, K. M. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 4
SP  - 810
EP  - 817
SN  - 0022-1899
AD  - Nguyen, B. Y. T.: Bldg 10, Rm 12N226, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942004878.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 59277-89-3, 69655-05-6, 7841-89-2, 30516-87-1. 
KW  - aciclovir
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - didanosine
KW  - Dideoxycytidine
KW  - HIV infections
KW  - Treatment
KW  - Zidovudine
KW  - acyclovir
KW  - AIDS
KW  - AZT
KW  - Combination drugs
KW  - dideoxyinosine
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of a recombinant CD4-IgG on in vitro T helper cell function: data from a phase I/II study of patients with AIDS.
AU  - Clerici, M.
AU  - Yarchoan, R.
AU  - et al.
AU  - Blatt, S. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 4
SP  - 1012
EP  - 1016
SN  - 0022-1899
AD  - Clerici, M.: Experimental Immunology Branch, National Cancer Institute, Building 10, Rm 4B-17, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942004883.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - HIV infections
KW  - Treatment
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - Recombinant CD4 immunoglobulin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytomegalovirus infection and risk of AIDS in human immunodeficiency virus-infected hemophilia patients.
AU  - Rabkin, C. S.
AU  - Hatzakis, A.
AU  - et al.
AU  - Griffiths, P. D. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 5
SP  - 1260
EP  - 1263
SN  - 0022-1899
AD  - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd, EPN/434, Rockville, MD 20852, USA.
N1  - Accession Number: 19942005123.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - disease course
KW  - haemophilia
KW  - HIV infections
KW  - Opportunistic infections
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - AIDS
KW  - disease progression
KW  - hemophilia
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005123&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High prevalence of hepatitis C virus (HCV) RNA in dialysis patients: failure of commercially available antibody tests to identify a significant number of patients with HCV infection.
AU  - Bukh, J.
AU  - Wantzin, P.
AU  - Krogsgaard, K.
AU  - Knudsen, F.
AU  - Purcell, R. H.
AU  - Miller, R. H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 6
SP  - 1343
EP  - 1348
SN  - 0022-1899
AD  - Bukh, J.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 7, Room 201, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028259.  Publication Type: Journal Article.  Corporate Author: Denmark, Copenhagen Dialysis HCV Study Group. Language: English.  Subject Subsets: Public Health
N2  - Results of serologic tests were correlated with hepatitis C virus (HCV) viraemia, determined by a cDNA polymerase chain reaction assay to detect HCV RNA, in 340 Danish dialysis patients; of these, 28 (8.2%) were positive for antibodies to HCV (anti-HCV) with second-generation ELISAs. HCV RNA was found in sera from 27 of these 28 anti-HCV-positive patients. However, 8 dialysis patients had detectable levels of HCV RNA but were anti-HCV-negative with second-generation ELISAs. Among the 35 HCV-infected dialysis patients 16 were positive, 7 indeterminate, and 12 negative with the second-generation RIBA. More than 60% of patients with evidence of ongoing liver disease had HCV infection. Thus, current commercially available antibody tests did not accurately reflect the HCV status in dialysis patients. A relatively high prevalence (&gt;10%) of HCV RNA, closely associated with liver disease, was found among dialysis patients in a low-prevalence area of the world. AS
KW  - diagnosis
KW  - dialysis
KW  - ELISA
KW  - failure
KW  - Hepatitis C
KW  - patients
KW  - Denmark
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - enzyme linked immunosorbent assay
KW  - prevalence
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quinolinic acid in the cerebrospinal fluid of children with symptomatic human immunodeficiency virus type 1 disease: relationships to clinical status and therapeutic response.
AU  - Brouwers, P.
AU  - Heyes, M. P.
AU  - et al.
AU  - Moss, H. A. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 6
SP  - 1380
EP  - 1386
SN  - 0022-1899
AD  - Brouwers, P.: Pediatric Branch, National Cancer Institute, NIH Clinical Center, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005270.  Publication Type: Journal Article.  Language: English. 
KW  - Cerebrospinal fluid
KW  - Disease markers
KW  - HIV infections
KW  - Paediatrics
KW  - human immunodeficiency virus infections
KW  - pediatrics
KW  - Quinolinic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Congenital yellow fever virus infection after immunization in pregnancy.
AU  - Tsai, T. F.
AU  - Paul, R.
AU  - Lynberg, M. C.
AU  - Letson, G. W.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 6
SP  - 1520
EP  - 1523
SN  - 0022-1899
AD  - Tsai, T. F.: Clinical Microbiology Service, Bldg. 10 2C-385, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028293.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - To determine whether yellow fever (YF) vaccine administered in pregnancy causes fetal infection, [47] women who were vaccinated during unrecognized pregnancy in a mass campaign in Trinidad were studied retrospectively. Maternal and cord or infant blood were tested for IgM and neutralizing antibodies to YF and dengue viruses. One of 41 infants had IgM and elevated neutralizing antibodies to YF virus, indicating congenital infection. The infant, the first reported case of YF virus infection after immunization in pregnancy, was delivered after an uncomplicated full-term pregnancy and appeared normal. Congenital dengue 1 infection may have occurred in another case. The frequency of fetal infection and adverse events after such exposure could not be estimated; however, the neurotropism of YF virus for the developing nervous system and the now documented possibility of transplacental infection underscores the admonition that YF vaccination in pregnancy should be avoided.AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;To determine whether yellow fever (YF) vaccines administered in pregnancy causes fetal infection, women who were vaccinated during unrecognized pregnancy in a mass campaign in Trinidad were studied retrospectively. Maternal and cord or infant blood were tested for IgM and neutralizing antibodies to YF and dengue viruses. 1 of 41 infants had IgM and elevated neutralizing antibodies to YF viruses, indicating congenital infection. The infant, the first reported case of YF virus infection after immunization in pregnancy, was delivered after an uncomplicated full-term pregnancy and appeared normal. Congenital dengue 1 infection may have occurred in another case. The frequency of fetal infection and adverse events after such exposure could not be estimated; however, the neurotropism of YF virus for the developing nervous system and the now documented possibility of transplacental infection underscores the admonition that YF vaccination in pregnancy should be avoided.
KW  - arboviruses
KW  - case reports
KW  - congenital infection
KW  - human diseases
KW  - immunization
KW  - pregnancy
KW  - vaccination
KW  - women
KW  - Yellow fever
KW  - Caribbean
KW  - Trinidad and Tobago
KW  - dengue virus
KW  - Flavivirus
KW  - man
KW  - yellow fever virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Lesser Antilles
KW  - Antilles
KW  - Caribbean
KW  - Threshold Countries
KW  - arthropod-borne viruses
KW  - gestation
KW  - immune sensitization
KW  - prenatal infection
KW  - Trinidad & Tobago
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Reproduction and Development (VV060) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Defective antifungal activity of monocyte-derived macrophages from human immunodeficiency virus-infected children against Aspergillus fumigatus.
AU  - Roilides, E.
AU  - Holmes, A.
AU  - Blake, C.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1993///
VL  - 168
IS  - 6
SP  - 1562
EP  - 1565
SN  - 0022-1899
AD  - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200374.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - The antifungal activity against A. fumigatus of peripheral blood monocyte-derived macrophages (MDM) from 19 HIV-positive children from Maryland, USA, was compared with that of 16 normal controls. The phagocytic activity of patients' MDM, measured as percentage of phagocytosis, was significantly decreased compared with normal subjects (P=0.014). The inhibitory activity of MDM on germination of intracellular A. fumigatus conidia was significantly impaired in patients compared with normal controls (P=0.016). There was no significant difference in the defects between patients with lower or higher CD4 lymphocyte counts. It is suggested that impairment of antifungal activity of macrophages may contribute to the susceptibility of HIV-infected patients to aspergillosis.&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;... The antifungal activity of peripheral blood monocyte-derived macrophages (MDM) from 19 HIV-infected children was compared with that of 16 normal controls. The phagocytic activity of patients' MDM, measured as percentage of phagocytosis, was significantly decreased compared with normal donors (P = 0.014). In addition, the inhibitory activity of MDM on germination of intracellular Aspergillus fumigatus conidia was significantly impaired in patients compared with normal controls (P = 0.016). There was no significant difference in the defects between patients with lower or higher CD4 lymphocyte counts. Impairment of antifungal activity of macrophages may contribute to the susceptibility of HIV-infected patients to aspergillosis. AS
KW  - acquired immune deficiency syndrome
KW  - activity
KW  - antifungal agents
KW  - antimicrobial properties
KW  - aspergillosis
KW  - children
KW  - Clinical aspects
KW  - defects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - immunology
KW  - infections
KW  - macrophages
KW  - opportunistic infections
KW  - Paediatrics
KW  - predisposition
KW  - Maryland
KW  - North America
KW  - USA
KW  - Aspergillus fumigatus
KW  - man
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - anti-microbial properties
KW  - clinical picture
KW  - fungistats
KW  - fungus
KW  - HIV patients
KW  - Human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - pediatrics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes.
AU  - Marconi, R. T.
AU  - Samuels, D. S.
AU  - Garon, C. F.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1993///
VL  - 175
IS  - 4
SP  - 926
EP  - 932
SN  - 0021-9193
AD  - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940500333.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - In Lyme disease spirochaetes, the ospC gene encodes a 22.7-kDa protein referred to as either the pC or the OspC protein. Using a variety of electrophoretic approaches followed by Southern blotting and probing with oligonucleotide probes, the ospC gene to a circular 26-kb plasmid was mapped. The ospC gene represents the first gene to be mapped to a circular plasmid in Lyme disease spirochaetes. The occurrence of this gene in isolates belonging to each of the 3 Lyme disease-associated species, Borrelia burgdorferi, B. garinii and the VS461 group [B.afzelii], was evaluated. The ospC gene was found to occur in all 21 isolates tested from each of the 3 species. Differential hybridization with a series of ospC probes in both Northern (RNA) and Southern blot analyses demonstrated that there is sequence variability in the ospC gene among isolates. While the gene was found to be present in all isolates, not all actively transcribed the gene. Transcriptional start site analyses suggested that the gene may be under the control of multiple promoters that are highly similar in nucleotide sequence.
KW  - antigens
KW  - biotechnology
KW  - DNA hybridization
KW  - gene mapping
KW  - genes
KW  - immunoblotting
KW  - molecular genetics
KW  - nucleotide sequences
KW  - proteins
KW  - transcription
KW  - Borrelia afzelii
KW  - Borrelia burgdorferi
KW  - Borrelia garinii
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - DNA transcription
KW  - immunogens
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500333&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Abnormal in vitro proliferation and differentiation of T cell colony-forming cells in patients with tropical spastic paraparesis/human T lymphocyte virus type I (HTLV-I)-associated myeloencephalopathy and healthy HTLV-I carriers.
AU  - Lunardi-Iskandar, Y.
AU  - Gessain, A.
AU  - Lam, V. H.
AU  - Gallo, R. C.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1993///
VL  - 177
IS  - 3
SP  - 741
EP  - 750
SN  - 0022-1007
AD  - Lunardi-Iskandar, Y.: (R.C. Gallo) Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg 37, Rm 6A09, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932023461.  Publication Type: Journal Article.  Language: English. 
KW  - cellular biology
KW  - HTLV infections
KW  - Immune response
KW  - Immunology
KW  - Pathogenesis
KW  - T lymphocytes
KW  - cell biology
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Proliferation
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High human T cell lymphoctropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease.
AU  - Elovaara, I.
AU  - Koenig, S.
AU  - Brewah, A. Y.
AU  - Woods, R. M.
AU  - Lehky, T.
AU  - Jacobson, S.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1993///
VL  - 177
IS  - 3
SP  - 1567
EP  - 1573
SN  - 0022-1007
AD  - Elovaara, I.: Neuroimmunology Branch, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051324.  Publication Type: Journal Article.  Language: English. 
KW  - cytotoxic T lymphocytes
KW  - HTLV-I infections
KW  - myelopathy
KW  - tropical spastic paraparesis
KW  - pathogeneis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051324&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selection of rabbit CD4-CD8- T cell receptor-γ/δ cells by in vitro transformation with human T lymphotropic virus-I.
AU  - Sawasdikosol, S.
AU  - Hague, B. F.
AU  - et al.
AU  - Zhao, T. M. (
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1993///
VL  - 178
IS  - 4
SP  - 1337
EP  - 1345
SN  - 0022-1007
AD  - Sawasdikosol, S.: (T.J. Kindt) Laboratory of Immunogenetics, NIAID Twinbrook II Facility, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.
N1  - Accession Number: 19942006745.  Publication Type: Journal Article.  Language: English. 
KW  - Animal models
KW  - Experimental infections
KW  - Immunology
KW  - Deltaretrovirus
KW  - HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE I
KW  - Rabbits
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Emergence of NK1.1+ cells as effectors of IFN-γ dependent immunity to Toxoplasma gondii in MHC class I-deficient mice.
AU  - Denkers, E. Y.
AU  - Gazzinelli, R. T.
AU  - Martin, D.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1993///
VL  - 178
IS  - 5
SP  - 1465
EP  - 1472
SN  - 0022-1007
AD  - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950807815.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9008-11-1.  Subject Subsets: Tropical Diseases
N2  - In order to assess the role of CD8+ cells in resistance against Toxoplasma gondii, the ability of β2m-deficient mice to survive tachyzoite challenge following vaccination with an attenuated parasite mutant was studied. Vaccination of these mice induced strong resistance to lethal challenge, with &gt;50% surviving beyond 3 months. Vaccinated β2m-deficient mice, but not control heterozygotes, showed a 5- to 6-fold expansion in spleen cell number and ~40% of the splenocytes were found to express the NK markers NK1.1 and asialo GM1. Spleen cells from the vaccinated mice failed to kill either infected host cells or the NK target YAC-1. However, high levels of interferon-γ (IFN-γ) were secreted when the cells were cultured in vitro with soluble T. gondii lysate, and this response was abolished by NK1.1+ but not CD4+ and CD8+ lymphocyte depletion, implicating the NK1.1+ as the major source of IFN-γ. More importantly, vaccine-induced immunity in these mice was completely abrogated by in vivo administration of antibody to NK1.1, asialo GM1, or IFN-γ. These data suggest that in class-I deficient mice vaccinated against T. gondii, the absence of CD8+ cells is compensated for by the emergence of a population of NK1.1+ and asialo GM1 cells which lack cytolytic activity, and that the protective action of these cells against the parasite is attributable to IFN-γ.
KW  - cell mediated immunity
KW  - experimental infections
KW  - immune response
KW  - immunity
KW  - immunization
KW  - immunology
KW  - in vitro
KW  - interferon
KW  - laboratory animals
KW  - natural killer cells
KW  - T lymphocytes
KW  - tachyzoites
KW  - Toxoplasmosis
KW  - mice
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - cellular immunity
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807815&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.
AU  - Stanley, S. K.
AU  - McCune, J. M.
AU  - et al.
AU  - Kaneshima, H. (
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1993///
VL  - 178
SP  - 1151
EP  - 1163
SN  - 0022-1007
AD  - Stanley, S. K.: Laboratory of Immunoregulation, National Institutes of Health, Building 10, room 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006792.  Publication Type: Journal Article.  Language: English. 
KW  - CD4+ lymphocytes
KW  - CD8+ lymphocytes
KW  - HIV infections
KW  - Immunology
KW  - Immunosuppression
KW  - thymus gland
KW  - Mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4+ cells
KW  - CD8+ cells
KW  - human immunodeficiency virus infections
KW  - T4 lymphocytes
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006792&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analogues of butyric acid that increase the expression of transfected DNAs.
AU  - Carstea, E. D.
AU  - Miller, S. P. F.
AU  - Christakis, H.
AU  - O'Neill, R. R.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1993///
VL  - 192
IS  - 2
SP  - 649
EP  - 656
SN  - 0006-291X
AD  - Carstea, E. D.: Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, Building 10, Room 3D-04, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940102741.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 107-92-6.  Subject Subsets: Agricultural Biotechnology
N2  - 14 analogues of butryic acid were screened for the ability to upregulate expression of 3 chloramphenicol acetyl transferase (CAT) vectors stably integrated into NIH 3T3 cells. Butyric acid, 2-bromobutyric acid, 3-bromopropionic acid, 3-mercaptopropionic acid, vinylacetic acid and butyraldehyde upregulated the human immunodeficiency virus long terminal repeat, the simian virus 40 early promoter and glucocerebrosidase promoter-directed gene expression in the cultured cells.
KW  - analogues
KW  - biotechnology
KW  - butyric acid
KW  - cell lines
KW  - gene expression
KW  - human immunodeficiency viruses
KW  - promoters
KW  - recombinant DNA
KW  - mammals
KW  - simian virus 40
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - simian polyomaviruses
KW  - analogs
KW  - butanoic acid
KW  - enhancement
KW  - glucocerebrosidase
KW  - human immunodeficiency virus
KW  - promoter region
KW  - promoter sequences
KW  - upregulation
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940102741&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro infection of human bone marrow by feline leukemia viruses.
AU  - Morgan, R. A.
AU  - Dornsife, R. E.
AU  - French Anderson, W.
AU  - Hoover, E. A.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1993///
VL  - 193
IS  - 1
SP  - 439
EP  - 442
SN  - 0042-6822
AD  - Morgan, R. A.: Molecular Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952206004.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Veterinary Science
N2  - About 5 to 10% of the bulk human marrow culture could be infected by feline leukaemia virus.
KW  - feline leukaemia
KW  - cats
KW  - Gammaretrovirus
KW  - man
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - feline leukemia
KW  - feline leukosis
KW  - feline oncovirus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pets and Companion Animals (LL070) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952206004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Niemann-Pick C disease: cystine and lipids accumulate in the murine model of this lysosomal cholesterol lipidosis.
AU  - Butler, J. D.
AU  - Vanier, M. T.
AU  - Pentchev, P. G.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1993///
VL  - 196
IS  - 1
SP  - 154
EP  - 159
SN  - 0006-291X
AD  - Butler, J. D.: Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 10 Rm.10N308, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951403443.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 57-88-5, 56-89-3.  Subject Subsets: Animal Nutrition; Human Nutrition
N2  - Cystine values in tissues of the BALB/C mouse model of type C Niemann-Pick disease were greatly increased. Subcellular fractionation of liver homogenates by differential centrifugation suggested preferential accumulation in a fraction corresponding to lysosomes. Developmentally, a sharp increase in the accumulation of cystine in the mutant mouse liver occurs subsequent to a similar change in the accumulation of cholesterol, sphingomyelin and glucocerebroside. The lysosomal accumulation of cystine in this mutant mouse provides the experimental opportunity to study some aspects of the deficiency of lysosomal transport noted in cystinosis.
KW  - animal models
KW  - cholesterol
KW  - cystine
KW  - lipidosis
KW  - lipids
KW  - liver
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - lipins
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403443&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells.
AU  - Saunders, N. A.
AU  - Smith, R. J.
AU  - Jetten, A. M.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1993///
VL  - 197
IS  - 1
SP  - 46
EP  - 54
SN  - 0006-291X
AD  - Saunders, N. A.: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19940404040.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9007-49-2.  Subject Subsets: Dairy Science
KW  - differentiation
KW  - DNA
KW  - epithelium
KW  - genes
KW  - mammary glands
KW  - nucleic acids
KW  - regulation
KW  - senescence
KW  - tissue proliferation
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - proliferative disorders
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940404040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spontaneous and inducible epidermal hyperlasia in transgenic mice expressing HIV-1 Nef.
AU  - Dickie, P.
AU  - Ramsdell, F.
AU  - Notkins, A. L.
AU  - Venkatesan, S.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1993///
VL  - 197
IS  - 1
SP  - 431
EP  - 438
SN  - 0042-6822
AD  - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases.
N1  - Accession Number: 19952009816.  Publication Type: Journal Article.  Language: English. 
N2  - In HIV/Nef transgenic mouse lines, nef expression was detected exclusively in the skin and a significant fraction of HIV/Nef transgenic animals (30-75%, depending on the line) spontaneously developed discrete proliferative skin lesions resembling papillomas that were often accompanied by a progressive ulceration of the epidermal cell layer. Nef protein was detected in the basal cell layer of the epidermis and was elevated in the proliferating epidermis. Epidermal cell proliferation could be induced by UV-C irradiation of HIV/Nef transgenic animals but not control mice. An increase in nef expression in the skin accompanied this proliferation. MMTV/Nef mouse lines expressed Nef RNA and protein in organs typically permissive for MMTV LTR-directed transcription but with no obvious pathological consequence.
KW  - genetically engineered organisms
KW  - human diseases
KW  - transgenic animals
KW  - Human immunodeficiency virus 1
KW  - man
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GMOs
KW  - human immunodeficiency virus type 1
KW  - transgenic organisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009816&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of Rev-mediated HIV-1 expression by an RNA binding protein encoded by the interferon-inducible 9-27 gene.
AU  - Constantoulakis, P.
AU  - Campbell, M.
AU  - Felber, B. K.
AU  - Nasioulas, G.
AU  - Afonina, E.
AU  - Pavlakis, G. N.
JO  - Science, USA
JF  - Science, USA
Y1  - 1993///
VL  - 259
IS  - Feb. 26
SP  - 1314
EP  - 1318
AD  - Constantoulakis, P.: (G.N. Pavlakis) Human Retrovirus Section, National Cancer Institute-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, MD 21702, USA.
N1  - Accession Number: 19932020566.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 9008-11-1. 
KW  - cellular biology
KW  - Gene expression
KW  - human immunodeficiency viruses
KW  - Interferon
KW  - Molecular biology
KW  - Regulation
KW  - Transcription
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cell biology
KW  - DNA transcription
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Post-transcription
KW  - Rev
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020566&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of the von Hippel-Lindau disease tumor suppressor gene.
AU  - Latif, F.
AU  - Tory, K.
AU  - Gnarra, J.
AU  - Yao, M.
AU  - Duh, F. M.
AU  - Orcutt, M. L.
AU  - Stackhouse, T.
AU  - Kuzmin, I.
AU  - Modi, W.
AU  - Geil, L.
AU  - Schmidt, L.
AU  - Zhou, F. W.
AU  - Li, H.
AU  - Wei, M. H.
AU  - Chen, F.
AU  - Glenn, G.
AU  - Choyke, P.
AU  - Walther, M. M.
AU  - Weng, Y. K.
AU  - Duan, D. S. R.
AU  - Dean, M.
AU  - Glavač, D.
AU  - Richards, F. M.
AU  - Crossey, P. A.
AU  - Ferguson-Smith, M. A.
AU  - Le Paslier, D.\Chumakov, I.\Cohen, D.\Chinault, A. C.\Maher, E. R.\Marston Linehan, W.\Zbar, B.\Lerman, M. I.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1993///
VL  - 260
IS  - 5112
SP  - 1317
EP  - 1320
SN  - 0036-8075
AD  - Latif, F.: Laboratory of Immunobiology, National Cancer Institute - Frederick Cancer Research and Development Center (NCI-FCRDC), Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19950806150.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Protozoology
N2  - A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL) disease tumor suppressor gene. The VHL gene is evolutionarily conserved and encodes two widely expressed transcripts of approximately 6 and 6.5 kilobases. The partial sequence of the inferred gene product shows no homology to other proteins, except for an acidic repeat domain found in the procyclic surface membrane glycoprotein of Trypanosoma brucei.
KW  - genes
KW  - kidney diseases
KW  - molecular genetics
KW  - neoplasms
KW  - nucleotide sequences
KW  - parasites
KW  - protozoa
KW  - Trypanosoma brucei
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - biochemical genetics
KW  - cancers
KW  - cloning
KW  - DNA sequences
KW  - kidney disorders
KW  - nephropathy
KW  - renal diseases
KW  - von Hippel-Lindau disease tumour suppressor gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806150&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A linkage between DNA markers on the X chromosome and male sexual orientation.
AU  - Hamer, D. H.
AU  - Hu, S.
AU  - Magnuson, V. L.
AU  - Hu, N.
AU  - Pattatucci, A. M. L.
JO  - Science, USA
JF  - Science, USA
Y1  - 1993///
VL  - 261
IS  - July 16
SP  - 321
EP  - 327
AD  - Hamer, D. H.: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004604.  Publication Type: Journal Article.  Language: English. 
KW  - genes
KW  - Homosexuality
KW  - human immunodeficiency viruses
KW  - sociology
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - homosexuals
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - social aspects
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004604&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a.
AU  - Lei, K. J.
AU  - Shelly, L. L.
AU  - Pan, C. J.
AU  - Sidbury, J. B.
AU  - Chou, J. Y.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1993///
VL  - 262
IS  - 5133
SP  - 580
EP  - 583
SN  - 0036-8075
AD  - Lei, K. J.: Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941404472.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9001-39-2.  Subject Subsets: Human Nutrition
N2  - Glycogen storage disease type 1a is caused by deficiency of D-glucose-6-phosphatase (G6Pase), the key enzyme in glucose homeostasis. Despite both a high incidence and morbidity, the molecular mechanisms underlying this deficiency have eluded characterisation. In this study, the molecular and biochemical characterisation of the human G6Pase complementary DNA, its gene and the expressed protein, which is indistinguishable from human microsomal G6Pase, are reported. Several mutations in the G6Pase gene of affected individuals that completely inactivate the enzyme have been identified. The results establish the molecular basis of this disease and open the way for future gene therapy.
KW  - deficiency
KW  - genetic disorders
KW  - glucose-6-phosphatase
KW  - glycogenosis
KW  - molecular biology
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - genetic defects
KW  - glycogen disease
KW  - glycogen storage disease
KW  - glycogenic hepatomegaly
KW  - hereditary defects
KW  - Pompe's disease
KW  - Von Gierke's disease
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404472&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pyruvate and lactate metabolism in the in vivo dog heart.
AU  - Laughlin, M. R.
AU  - Taylor, J.
AU  - Chesnik, A. S.
AU  - DeGroot, M.
AU  - Balaban, R. S.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1993///
VL  - 264
IS  - 6, 2
SP  - H2068
EP  - H2079
SN  - 0002-9513
AD  - Laughlin, M. R.: Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941405348.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 56-65-5, 50-21-5, 127-17-3.  Subject Subsets: Human Nutrition
N2  - The extraction, intracellular carbon, and high energy phosphate metabolism of lactate and pyruvate were measured in vivo in the dog heart. Pyruvate fractional extraction exceeded that of lactate by a factor of 5, and elevated pyruvate severely reduced the net uptake of lactate but not its transport into the cell. Pyruvate also inhibited myocardial lactate dehydrogenase, and lactate relieved this inhibition. Both substrates suppressed oxidation of other molecules and caused intracellular free magnesium to decrease but did not alter work output or O2 extraction. Pyruvate, but not lactate, resulted in a decrease in adenosine diphosphate and an elevated phosphorylation potential. The change in phosphorylation potential is therefore due to a cytosolic event, most likely the redox state. The data indicate that the phosphorylation potential of the heart is a function of the cytosolic as well as mitochondrial energy state, and that this can be manipulated in vivo by choice of substrate.
KW  - ATP
KW  - heart
KW  - lactic acid
KW  - metabolism
KW  - pyruvic acid
KW  - dogs
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adenosine triphosphate
KW  - lactate
KW  - pyruvate
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405348&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of adenosine antagonists on hexose uptake and preconditioning in perfused rat heart.
AU  - Murphy, E.
AU  - Fralix, T. A.
AU  - London, R. E.
AU  - Steenbergen, C.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1993///
VL  - 265
IS  - 4
SP  - C1146
EP  - C1155
SN  - 0002-9513
AD  - Murphy, E.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19951407750.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 58-61-7.  Subject Subsets: Human Nutrition; Animal Nutrition
KW  - adenosine
KW  - antagonists
KW  - heart
KW  - hexoses
KW  - metabolism
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407750&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification.
AU  - Ziegelstein, R. C.
AU  - Cheng, L.
AU  - Blank, P. S.
AU  - Spurgeon, H. A.
AU  - Lakatta, E. G.
AU  - Hansford, R. G.
AU  - Capogrossi, M. C.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1993///
VL  - 265
IS  - 4
SP  - H1424
EP  - H1433
SN  - 0002-9513
AD  - Ziegelstein, R. C.: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore 21224, USA.
N1  - Accession Number: 19951407745.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 7440-70-2.  Subject Subsets: Human Nutrition; Animal Nutrition
KW  - acid base equilibrium
KW  - acidosis
KW  - calcium
KW  - cell cultures
KW  - endothelium
KW  - homeostasis
KW  - pH
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hydrogen ion concentration
KW  - metabolic acidosis
KW  - potential of hydrogen
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407745&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Multiple genes encode the major surface glycoprotein of Pneumocystis carinii.
AU  - Kovacs, J. A.
AU  - Powell, F.
AU  - Edman, J. C.
AU  - Lundgren, B.
AU  - Martinez, A.
AU  - Drew, B.
AU  - Angus, C. W.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1993///
VL  - 268
IS  - 8
SP  - 6034
EP  - 6040
SN  - 0021-9258
AD  - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931251633.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - Seven related but unique genes encoding the major surface glycoprotein of rat P. carinii were cloned and sequenced. Partial amino acid sequencing confirmed the identity of these genes. Based on Southern blot studies using chromosomal or restricted DNA, the major surface glycoproteins are the products of a multicopy family of genes. The predicted protein has an Mr of approx. 123 000, is relatively rich in cysteine residues (5.5%) that are very strongly conserved, and contains a well conserved hydrophobic region at the carboxyl terminus. It is concluded that the presence of multiple related msg genes encoding the major surface glycoprotein of P. carinii indicates that antigenic variation is a possible mechanism for evading host defences.
KW  - antigens
KW  - DNA sequencing
KW  - genes
KW  - genetics
KW  - glycoproteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - immunology
KW  - Molecular biology
KW  - molecular genetics
KW  - nucleotide sequences
KW  - opportunistic infections
KW  - parasites
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - invertebrates
KW  - animals
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - fungus
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - immunogens
KW  - Major surface glycoprotein
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251633&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Autophosphorylation-independent activation of Acanthamoeba myosin I heavy chain kinase by plasma membranes.
AU  - Kulesza-Lipka, D.
AU  - Brzeska, H.
AU  - Baines, I. C.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1993///
VL  - 268
IS  - 24
SP  - 17995
EP  - 18001
SN  - 0021-9258
AD  - Kulesza-Lipka, D.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805410.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Protozoology
N2  - The 3 isoforms of Acanthamoeba castellanii myosin I (non-filamentous myosin with only a single heavy chain) express actin-activated Mg2+-ATPase activity only when phosphorylated at a single site by myosin I heavy chain kinase. The kinase is activated by autophosphorylation that is greatly stimulated by acidic phospholipids. Substantial fractions of the 3 myosins I and the kinase are associated in situ with membranes, and all 4 enzymes bind to purified membranes in vitro. It is reported that when kinase and myosin I are incubated together with phosphatidylserine vesicles, not only does the kinase autophosphorylate more rapidly than soluble kinase in the absence of phosphatidylserine but that, probably as a result, the kinase phosphorylates myosin I more rapidly than soluble kinase phosphorylates soluble myosin I. Similarly, plasma membrane-bound kinase phosphorylates membrane-bound myosin I and activates its actin-activated Mg2+-ATPase activity more rapidly than soluble kinase phosphorylates and activates soluble myosin I in the absence of membranes. However, the enhanced activity of membrane-bound kinase (which is comparable to the activity of kinase in the presence of phosphatidylserine) is not due to autophosphorylation of the membrane-bound kinase, which is very much slower than for kinase activated by phosphatidylserine vesicles.
KW  - biochemistry
KW  - kinases
KW  - myosins
KW  - parasites
KW  - Acanthamoeba castellanii
KW  - acanthamoebidae
KW  - protozoa
KW  - sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805410&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker.
AU  - Di Marzo Veronese, F.
AU  - Reitz, M. S. Jr
AU  - et al.
AU  - Gupta, G. (
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1993///
VL  - 268
IS  - 34
SP  - 25894
EP  - 25901
SN  - 0021-9258
AD  - Di Marzo Veronese, F.: Laboratory of Tumor Cell Biology, Building 37, Room 6B23, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005568.  Publication Type: Journal Article.  Language: English. 
KW  - Conformation
KW  - envelope protein gp120
KW  - epitopes
KW  - human immunodeficiency viruses
KW  - Immunology
KW  - Monoclonal antibodies
KW  - Neutralization
KW  - Pathogenesis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenic determinants
KW  - body conformation
KW  - gp120
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005568&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation.
AU  - Mills, J. L.
AU  - Holmes, L. B.
AU  - Aarons, J. H.
AU  - Simpson, J. L.
AU  - Brown, Z. A.
AU  - Jovanovic-Peterson, L. G.
AU  - Conley, M. R.
AU  - Graubard, B. I.
AU  - Knopp, R. H.
AU  - Metzger, B. E.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 5
SP  - 593
EP  - 597
SN  - 0098-7484
AD  - Mills, J. L.: Pediatric Epidemiology Section, Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Building, Room 7B03, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941402651.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 58-08-2.  Subject Subsets: Human Nutrition
N2  - Within 21 days of conception 431 women were enrolled in a multicentre study which lasted throughout pregnancy. Mean caffeine consumption during the first trimester was not significantly greater in women who aborted (125.9±123.1) than in women who delivered live infants (111.6±107.0 mg). The adjusted odds ratio (OR) for spontaneous abortion was 1.15 (95% confidence interval (CI), 0.89 to 1.49). Early foetal growth, assessed by crown-rump length on ultrasonographic examination, was not affected by caffeine. Although the group who took most caffeine (&gt;300 mg daily) had a significantly higher proportion of babies with birth weight and head circumference below the 10th percentile in the crude analysis, the association with caffeine was no longer significant when other risk factors (especially smoking) were taken into account. The adjusted ORs were 1.11 (95% CI 0.88 to 1.40) for decreased birth weight and 1.09 (95% CI 0.86 to 1.37) for smaller head circumference.
KW  - abortion
KW  - birth weight
KW  - caffeine
KW  - fetal death
KW  - fetal growth
KW  - intake
KW  - pregnancy
KW  - risk
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disorders
KW  - foetal death
KW  - foetal growth
KW  - gestation
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402651&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation.
AU  - Mills, J. L.
AU  - Holmes, L. B.
AU  - et al.
AU  - Aarons, J. H. (
JO  - Journal of the American Medical Association
JF  - Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 5
SP  - 593
EP  - 597
AD  - Mills, J. L.: Pediatric Epidemiology Section, Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Building, Room 7B03, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020264.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Human Nutrition; Public Health
N2  - To examine the relationship between caffeine consumption during pregnancy and the occurrence of spontaneous abortion and intrauterine growth retardation, the authors investigated a cohort of 431 women enrolled in a multicentre study in the USA within 21 days of conception. They monitored the women throughout pregnancy to determine (1) caffeine exposure, (2) exposure to other risk factors, (3) fetal growth as assessed by ultrasonography, and (4) pregnancy outcome, measuring spontaneous abortion, intrauterine growth, birth weight, and head circumference.The mean (±SD) first-trimester caffeine consumption was not significantly higher in women who aborted (125.9±123.1 mg) than in women who delivered liveborn infants (111.6±107.0 mg) (P = 34). The adjusted odds ratio (OR) for spontaneous abortion was 1.15 (95% confidence interval [CI], 0.89 to 1.49). Early fetal growth, assessed by crown-rump length on ultrasonographic examination, was not affected by caffeine. Although the group consuming the most caffeine (&gt;300 mg/d) had a significantly higher proportion of babies with birth weights and head circumferences below the 10th percentile in the crude analysis, the association with caffeine was no longer significant when other risk factors (notably smoking) were taken into account. The adjusted ORs were 1.11 (95% CI, 0.88 to 1.40) for decreased birth weight and 1.09 (95% CI, 0.86 to 1.37) for smaller head circumference. [In the mouse (Renwick Med. Sci. Res. 1988 16, 431-2) and also in the rat (data of Collins et al., 1983, Food Chem. Toxicol, 21, 763-7) the detrimental effect of caffeine on total healthy litter mass follows a cube 'law'. In other words, the dose-response curve is non-linear and steep. Thus, if man follows a similar law, one expects the damage to be especially noticable among the heavier consumers of caffeine (≥300 mg/day) and the data are compatible with the expectation. The sample size (24) of this category is pitiably small and is further reduced to 13 (by non-availability of data) for the crucial test. It is therefore not surprising that the highly significant excess of low-birthweight infants (&lt;10th percentile) in this group becomes non-significant after adjustment for confounders.The authors unjustifiably claim "good statistical power" whereas their actual data could be entirely consistent with a marked detrimental effect of what they term "heavy" caffeine use-3 cups of coffee or more daily as an average over the three trimesters of pregnancy.]J.H. Renwick
KW  - abortion
KW  - beverages
KW  - coffee
KW  - Food
KW  - Pregnancy
KW  - women
KW  - Coffea
KW  - man
KW  - Rubiaceae
KW  - Rubiales
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - caffeine use
KW  - drinks
KW  - gestation
KW  - intrauterine growth
KW  - spontaneous
KW  - Human Reproduction and Development (VV060) 
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020264&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Viral gastroenteritis.
AU  - Kapikian, A. Z.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 5
SP  - 627
EP  - 628
SN  - 0098-7484
AD  - Kapikian, A. Z.: National Institutes of Health, Bldg 7, Room 103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942020769.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A report of a case due to a rotavirus and discussion of other forms of viral gastroenteritis (eg. due to Norwalk virus).
KW  - Diarrhoea
KW  - gastroenteritis
KW  - infections
KW  - reviews
KW  - viral diseases
KW  - Norwalk virus
KW  - Rotavirus
KW  - Norovirus
KW  - Caliciviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Reoviridae
KW  - dsRNA viruses
KW  - diarrhea
KW  - scouring
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942020769&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Probing the meaning of racial/ethnic group comparisons in crack cocaine smoking.
AU  - Lillie-Blanton, M.
AU  - Anthony, J. C.
AU  - Schuster, C. R.
AU  - Fullilove, M. T.\Fullilove, M. T.
JO  - Journal of the American Medical Association
JF  - Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 8
SP  - 993
EP  - 997, 1034
AD  - Lillie-Blanton, M.: Addiction Research Center, National Institute on Drug Abuse, Alcohol, Drug Abuse, and Mental Health Administration, PO Box 5180, Baltimore, MD 21224, USA.
N1  - Accession Number: 19932020260.  Publication Type: Journal Article.  Language: English.  Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5.  Subject Subsets: Public Health
N2  - This article addresses an important issue in the epidemiology of drug use, namely "to make a distinction between race as a risk factor and race as a risk marker" as Mindy T. Fullilove puts it in an editorial (p. 1034). The authors reanalysed the data of the widely disseminated and accepted findings of the 1988 National Household Survey of Drug Abuse (NHSDA). This report showed prevalence rates for life-time (ever) use of crack cocaine to be twice as high for African Americans and Hispanic Americans as among white Americans. The analysis did not attempt to account for the underlying macrosocial environmental risk factors or determinants of prevalence, which may underpin the bases of interpreting the data. Macrosocial factors "operate at a societal rather than individual level ... and have their origin in constructs such as what is valued by people as important, the strength of beliefs and the extent to which individuals experience themselves as a part of a larger social organism". Methods and the statistical instruments are described in detail in the text. Suffice it to note that "once survey respondents were grouped into neighbourhood clusters, in effect holding constant shared characteristics, such as drug availability and social conditions, the odds of crack cocaine use did not differ significantly by race/ethnicity." N.H. Rathod
KW  - cocaine
KW  - crack
KW  - Drugs
KW  - crack cocaine
KW  - medicines
KW  - pharmaceuticals
KW  - racial/ethnic group comparisons
KW  - users
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020260&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Smoking and lung function in elderly men and women: the Cardiovascular Health Study.
AU  - Higgins, M. W.
AU  - Enright, P. L.
AU  - et al.
AU  - Kronmal, R. A. (
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 21
SP  - 2741
EP  - 2748
SN  - 0098-7484
AD  - Higgins, M. W.: National Institutes of Health, National Heart, Lung, and Blood Institute, Federal Bldg., Room 2C08, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942027221.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors investigated relationships between cigarette smoking and pulmonary function in total of 5201 non-institutionalized men and women 65 years of age and older from defined communities in Forsyth County, North Carolina; Pittsburg, Pennsylvania; Sacramento County, California; and Washington County, Maryland. Pulmonary function was measured as means of forced expiratory volume in 1 second (FEV1) and forced vital capacity and prevalence of low FEV1 levels. Prevalence of cigarette smoking was 10-20% and higher in women than men and in blacks than whites. Forced vital capacity and FEV1 levels were related positively to height and white race and negatively to age and waist girth. Age- and height-adjusted FEV1 means were 23% and 18% lower in male and female current smokers, respectively, than in never smokers but not reduced in never smokers currently living with a smoker. Smokers who quit before age 40 years had FEV1 levels similar to never smokers, but FEV1 levels were lower by 7% and 14% in smokers who quit at ages 40-60 years and older than 60 years, respectively. Lung function was related inversely to pack-years of cigarette use. Prevalence rates of impaired lung function were highest in current smokers and lowest in never smokers. Regression coefficients for the smoking variables were smaller in persons without cardiovascular or respiratory conditions than in the total cohort. Cigarette smoking is associated with reduced pulmonary function in elderly men and women. However, smokers who quit, even after age 60 years, have better pulmonary function than continuing smokers. From AS
KW  - elderly
KW  - lung function
KW  - Tobacco smoking
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - aged
KW  - elderly people
KW  - older adults
KW  - senior citizens
KW  - United States of America
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027221&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Declining serum total cholesterol levels among US adults: the National Health and Nutrition Examination Surveys.
AU  - Johnson, C. L.
AU  - Rifkind, B. M.
AU  - Sempos, C. T.
AU  - Carroll, M. D.
AU  - Bachorik, P. S.
AU  - Briefel, R. R.
AU  - Gordon, D. J.
AU  - Burt, V. L.
AU  - Brown, C. D.
AU  - Lippel, K.
AU  - Cleeman, J. I.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 23
SP  - 3002
EP  - 3008
SN  - 0098-7484
AD  - Johnson, C. L.: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institute of Health, BLdg 31, Room 4A-05, Bethesda MD 20892, USA.
N1  - Accession Number: 19941410573.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - National representative cross-sectional surveys with both in-person interview and a medical screening involving the measurement of blood lipids in 6000 and 13 000 adults 20 to 74 years old were examined in 4 separate surveys between 1960 and 1991. The study demonstrated that mean serum total cholesterol levels in US adults within this age range consistently declined over the time period l960 to l991. More than half of the decline occurred between 1976 and l991. This decline occurred across the entire distribution of serum cholesterol levels and in all age-sex groups. High-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol levels have not changed, suggesting that the decline in total cholesterol levels is due to a decline in low-density lipoprotein levels. Thus, public health programs, designed to reduce cholesterol levels, has proved successful. This trend has coincided with a continuing decline in coronary heart disease. The goal of reducing the mean serum cholesterol level of US adults to no more that 200 mg/100 ml (5.17 mmol/litre) appears to be attainable.
KW  - adults
KW  - blood
KW  - blood lipids
KW  - cardiovascular diseases
KW  - cholesterol
KW  - heart diseases
KW  - nutrition programmes
KW  - trends
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - coronary diseases
KW  - feeding programmes
KW  - feeding programs
KW  - food programs
KW  - nutrition programs
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevalence of high blood cholesterol among US adults: an update based on guidelines from the second report of the National Cholesterol Education Program Adult Treatment Panel.
AU  - Sempos, C. T.
AU  - Cleeman, J. I.
AU  - Carroll, M. D.
AU  - Johnson, C. L.
AU  - Bachorik, P. S.
AU  - Gordon, D. J.
AU  - Burt, V. L.
AU  - Briefel, R. R.
AU  - Brown, C. D.
AU  - Lippel, K.
AU  - Rifkind, B. M.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 23
SP  - 3009
EP  - 3014
SN  - 0098-7484
AD  - Sempos, C. T.: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 31, Room 4A-05, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941410576.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Human Nutrition
N2  - From the data collection in the second period of the National Health and Nutrition Examination Survey (NHANES II) (l976 through 1980) to the period in the third survey (NHANES III) (l988 through l991) the proportion of adults with high blood cholesterol levels (≥ 240 mg/100 ml) fell from 26 to 20%, while the proportion with desirable levels (below 200 mg/100 ml) increased from 44 to 49%. Currently, using the Adult Treatment Panel (ATP II) guidelines and NHANES III data, 40% of all adults 20 years or older would require fasting lipid analysis, and 29% of all adults would be candidates for dietary therapy (as compared with 36% using NHANES II data). Based on l990 population data, it is estimated that about 52 million Americans 20 years or older would be candidates for dietary therapy. Assuming that dietary intervention would reduce LDL cholesterol levels by 10%, as many as 7% (12.7 million) of all adult Americans might be candidates for cholesterol-lowering drugs. This estimate reflects about 4 million adults with established coronary heart disease, of whom half are 65 years old or older, and up to 8.7 million adults without established coronary heart disease, of whom up to 3.1 million are 65 years old or older.
KW  - adults
KW  - blood pressure
KW  - nutrition surveys
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - nutritional surveys
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410576&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of high blood cholesterol in adults (Adult Treatment Panel II).
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 269
IS  - 23
SP  - 3015
EP  - 3023
SN  - 0098-7484
AD  - National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 31, Room 4A-05, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941410574.  Publication Type: Journal Article.  Corporate Author: Expert Panel on Detection, Evaluaion, and Treatment of High Blood Cholesterol in Adults Language: English.  Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The second report of by Expert Panel of the National Cholesterol Education Program (NCEP) on detection, evaluation and treatment of high blood cholesterol in adults contains the following updated recommendations for cholesterol management: (1) Increased emphasis on coronary heart disease (CHD) risk as guide to type and intensity of cholesterol-lowering therapy, including identification of patients with CHD and other atherosclerotic diseases, (2) addition of age to the list of major CHD risk facts, (3) recommendation of delaying the use of drug therapy in younger men and premenopausal women who are otherwise at low risk for CHD and (4) enhanced recognition that high-risk postmenopausal women and high-risk elderly patients who are otherwise in good health, are candidates for cholesterol-lowering therapy. Also, (1) More attention to high-density lipoprotein (HDL) as a CHD risk factor, (2) addition of HDL cholesterol to initial cholesterol testing, (3) designation of high HDL cholesterol as a negative CHD risk factor and (4) consideration of HDL cholesterol level in the choice of drug therapy. Finally, increased emphasis on physical activity and weight loss as component of the dietary therapy of high blood pressure.
KW  - adults
KW  - blood
KW  - blood lipids
KW  - cholesterol
KW  - diet
KW  - diet treatment
KW  - hyperlipaemia
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - diet prescription
KW  - hyperlipemia
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410574&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiretroviral therapy for adult HIV-infected patients: recommendations from a State-of-the-Art Conference.
AU  - Sande, M. A.
AU  - Carpenter, C. C. J.
AU  - Cobbs, C. G.
AU  - Holmes, K. K.
AU  - Sanford, J. P.
AU  - Randall, P.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1993///
VL  - 270
IS  - 21
SP  - 2583
EP  - 2589
SN  - 0098-7484
AD  - Sande, M. A.: (P. Randall) Office of Communications, Building 31A, Room 7A50, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005347.  Publication Type: Journal Article.  Language: English.  Registry Number: 30516-87-1. 
KW  - analogues
KW  - Guidelines
KW  - HIV infections
KW  - nucleoside analogues
KW  - nucleosides
KW  - Treatment
KW  - Zidovudine
KW  - analogs
KW  - AZT
KW  - human immunodeficiency virus infections
KW  - nucleoside analogs
KW  - recommendations
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005347&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of maltase in the utilization of sucrose by Candida albicans.
AU  - Williamson, P. R.
AU  - Huber, M. A.
AU  - Bennett, J. E.
JO  - Biochemical Journal (London)
JF  - Biochemical Journal (London)
Y1  - 1993///
VL  - 291
IS  - 3
SP  - 765
EP  - 771
SN  - 0264-6021
AD  - Williamson, P. R.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931214831.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 9001-42-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - Two isoenzymes of maltase [α-glucosidase] (EC 3.2.1.20) were purified to homogeneity from C. albicans. Isoenzymes I and II were found to have apparent molecular masses of 63 and 66 kDa on SDS/PAGE with isoelectric points of 5.0 and 4.6, respectively. Both isoenzymes resembled each other in similar N-terminal sequence, specificity for the α(1-&gt;4) glycosidic linkage and immune cross-reactivity on Western blots using an α-glucosidase II antigen-purified rabbit antibody. α-Glucosidase was induced by growth on sucrose whereas β-fructofuranosidase activity could not be detected under similar conditions. α-Glucosidase I and II were shown to be unglycosylated enzymes by neutral sugar assay, and &gt;90% of α-glucosidase activity was recoverable from spheroplasts. An intracellular localization of the enzyme is suggested. To establish further the mechanism of sucrose assimilation by α-glucosidase, the existence of a sucrose-inducible H+/sucrose syn-transporter was demonstrated by the kinetics of sucrose-induced [14C]sucrose uptake, recovery of intact [14C]sucrose from ground cells by TLC and transport of 0.83 mol of H+/mol of [14C]sucrose. It is concluded that these results are consistent with a mechanism whereby sucrose is transported into C. albicans to be hydrolysed by an intracellular α-glucosidase.
KW  - alpha-glucosidase
KW  - enzymes
KW  - physiology
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - alpha-D-glucosidase
KW  - fungus
KW  - Hyphomycetes
KW  - maltase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma triglyceride level and mortality from coronary heart disease.
AU  - Criqui, M. H.
AU  - Heiss, G.
AU  - Cohn, R.
AU  - Cowan, L. D.
AU  - Suchindran, C. M.
AU  - Bangdiwala, S.
AU  - Kritchevsky, S.
AU  - Jacobs, D. R., Jr.
AU  - O'Grady, H. K.
AU  - Davis, C. E.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1993///
VL  - 328
IS  - 17
SP  - 122
EP  - 1225
SN  - 0028-4793
AD  - Criqui, M. H.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941400521.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The association between plasma triacylglycerol values and the 12-year incidence of death from coronary heart disease was studied in 10 North American populations participating in the Lipid Research Clinics Follow-up Study, while adjusting for the potential confounding effects of other risk factors for cardiovascular disease, including HDL cholesterol concentration. All analyses were sex-specific, and separate analyses were performed in high and low strata of HDL cholesterol, LDL cholesterol, fasting plasma glucose and age. The rates of coronary death in men and women increased with the triacylglycerol concentration. In Cox proportional-hazards models adjusted for age, in which the natural log of the triacylglycerol values were used to give a normal distribution, the relative risk per natural-log unit of triacylglycerol (e.g., a triacylglycerol value of 150 mg/100 ml compared with a value of 55 mg/100 ml) was 1.54 (95% confidence interval (CI) 1.19 to 1.98; P&lt;0.001) in men and 1.88 (95% CI 1.19 to 2.98; P = 0.007) in women. After an adjustment for potential covariates, however, these relative risks were not significant. Analyses based on lipoprotein cholesterol values revealed a positive association between the triacylglycerol value and coronary mortality in the lower stratum of HDL and LDL cholesterol, but not in the higher stratum. Conversely, the HDL cholesterol value was unrelated to coronary mortality in the lower stratum of LDL cholesterol, but was strongly inversely associated with coronary death in the higher stratum of LDL cholesterol. The relative risk of coronary death associated with triacylglycerol concentration was higher at younger ages. The associations between the triacylglycerol value and coronary mortality in the lower HDL cholesterol, LDL cholesterol and age strata were small and were further reduced by an adjustment for fasting plasma glucose. Overall, the plasma triacylglycerol value showed no independent association with coronary mortality. However, in subgroups of subjects with lower HDL and LDL cholesterol values and in younger subjects, defined a priori, an association between the triacylglycerol value and coronary mortality was observed, although this association was small and was not significant after an adjustment for plasma glucose.
KW  - age
KW  - blood
KW  - cholesterol
KW  - heart diseases
KW  - lipoproteins
KW  - mortality
KW  - sex differences
KW  - triacylglycerols
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - coronary diseases
KW  - death rate
KW  - triglycerides
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Educational status and active life expectancy among older blacks and whites.
AU  - Guralnik, J. M.
AU  - Land, K. C.
AU  - Blazer, D.
AU  - Fillenbaum, G. G.
AU  - Branch, L. G.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1993///
VL  - 329
IS  - 2
SP  - 110
EP  - 116
SN  - 0028-4793
AD  - Guralnik, J. M.: National Institute on Aging, 7201 Wisconsin Avenue, Rm. 3C-309, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932023362.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
KW  - adults
KW  - life expectancy
KW  - Mortality
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - America (North)
KW  - death rate
KW  - educational status
KW  - United States of America
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023362&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The risk of childhood cancer after neonatal exposure to vitamin K.
AU  - Klebanoff, M. A.
AU  - Read, J. S.
AU  - Mills, J. L.
AU  - Shiono, P. H.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1993///
VL  - 329
IS  - 13
SP  - 905
EP  - 908
SN  - 0028-4793
AD  - Klebanoff, M. A.: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Bldg., Room 7B03, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002356.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 12001-79-5.  Subject Subsets: Public Health
N2  - The authors examined the relation between vitamin K and cancer in a nested case-control study in the USA that used data from the Collaborative Perinatal Project, a multicentre, prospective study of pregnancy, delivery, and childhood. Among 54 795 children born from 1959 through 1966, 48 cases of cancer were diagnosed after the first day of life and before the eighth birthday. Each case child was matched with five randomly selected controls whose last study visit occurred at or after the age when the case child's cancer was diagnosed. Exposure to vitamin K was determined from study forms and medical records. Vitamin K has been administered to 68% of the 44 case children and 71% of the 226 controls for whom data were available (matched odds ratio, 0.84; 95% confidence interval, 0.41 to 1.71). The odds ratio was 0.47 (95% confidence interval, 0.14 to 1.55) for leukaemia and 1.08 (95% confidence interval, 0.45 to 2.61) for other cancers. Sequential adjustment for potential confounding factors did not change the results substantially. The authors found no association between exposure to vitamin K and an increased risk of any childhood cancer or of all childhood cancers combined, although a slightly increased risk could not be ruled out. The benefits of neonatal vitamin K prophylaxis against haemorrhagic disease have been well described. Unless other evidence supporting an association between vitamin K and cancer appears, there is no reason to abandon the routine administration of vitamin K to newborns.
KW  - children
KW  - human diseases
KW  - neoplasms
KW  - risk factors
KW  - vitamin K
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002356&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient.
AU  - Kost, R. G.
AU  - Hill, E. L.
AU  - Tigges, M.
AU  - Straus, S. E.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1993///
VL  - 329
IS  - 24
SP  - 1777
EP  - 1782
SN  - 0028-4793
AD  - Kost, R. G.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006511.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 59277-89-3. 
N2  - A case report in a 24-year-old man from USA.
KW  - aciclovir
KW  - case reports
KW  - herpes
KW  - human diseases
KW  - male genitalia
KW  - men
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - acyclovir
KW  - male genital system
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of HTLV-I in development of non-Hodgkin lymphoma in Jamaica and Trinidad and Tobago.
AU  - Manns, A.
AU  - Cleghorn, F. R.
AU  - et al.
AU  - Falk, R. T. (
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1993///
VL  - 342
IS  - Dec. 11
SP  - 1447
EP  - 1450
SN  - 0140-6736
AD  - Manns, A.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd 434, Rockville, MD 20852, USA.
N1  - Accession Number: 19942005033.  Publication Type: Journal Article.  Corporate Author: USA, HTLV Lymphoma Study Group Language: English. 
KW  - Aetiology
KW  - HTLV infections
KW  - non-Hodgkin's lymphoma
KW  - Risk factors
KW  - Caribbean
KW  - Jamaica
KW  - Trinidad and Tobago
KW  - America
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - Threshold Countries
KW  - Lesser Antilles
KW  - causal agents
KW  - etiology
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Trinidad & Tobago
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Procreation and HIV.
AU  - Dublin, S.
AU  - Blatner, W. A.
AU  - White, G. C. II
AU  - Goedert, J. J.
T2  - Lancet (British edition)
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1993///
VL  - 342
SP  - 1241
EP  - 1242
SN  - 0140-6736
AD  - Dublin, S.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19932004870.  Publication Type: Correspondence.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - haemophilia
KW  - Heterosexual transmission
KW  - HIV infections
KW  - Prevention
KW  - Safer sex
KW  - AIDS
KW  - hemophilia
KW  - human immunodeficiency virus infections
KW  - Procreation
KW  - safe sex
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004870&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Disseminated human herpesvirus 6 infection in AIDS.
AU  - Corbellino, M.
AU  - Lusso, P.
AU  - Gallo, R. C.
AU  - Parravicini, C.
AU  - Galli, M.
AU  - Moroni, M.
T2  - Lancet (British edition)
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1993///
VL  - 342
SP  - 1242
EP  - 1242
SN  - 0140-6736
AD  - Corbellino, M.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932004871.  Publication Type: Correspondence.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - disseminated infections
KW  - Pathogenesis
KW  - Human herpesvirus 6
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - AIDS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004871&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection of natural killer cells by human herpesvirus 6.
AU  - Lusso, P.
AU  - Malnati, M. S.
AU  - Garzino-Demo, A.
AU  - Crowley, R. W.
AU  - Long, E. O.
AU  - Gallo, R. C.
JO  - Nature, UK
JF  - Nature, UK
Y1  - 1993///
VL  - 362
IS  - Apr. 1
SP  - 458
EP  - 462
AD  - Lusso, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19932020511.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Natural killer (NK) cells are a functionally defined subset of non-T, non-B lymphocytes of bone marrow origin, which induce lysis of selected target cells, including neoplastic and virus-infected cells. The NK cell function provides an important mechanism of primary defence against viruses in vivo, as demonstrated by the occurrence of multiple herpesvirus infections in patients. The authors show that functionally competent CD3- NK clones can be productively infected by human herpesvirus 6 (HHV-6), a T-lymphotropic DNA virus that may play a role in the acquired immunodeficiency syndrome (AIDS) and in the chronic fatigue syndrome, two disorders associated with a defective NK cell activity. The infection is cytopathic and induces de novo expression of CD4 (an antigen not expressed within the NK lineage), thereby predisposing NK cells to infection by human immunodeficiency virus type 1 (HIV-1). These results provide evidence that a herpesvirus can directly target and kill NK cells, a potential strategy to suppress the natural anti-viral immunity of the host. AS/D.J. Morris
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - cellular biology
KW  - cofactors
KW  - envelope glycoproteins
KW  - HIV infections
KW  - Immunology
KW  - Natural killer cells
KW  - receptors
KW  - human herpesvirus 6
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - AIDS
KW  - CD4 expression
KW  - cell biology
KW  - human immunodeficiency virus infections
KW  - Immune dysfunction
KW  - killing
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for the development of obesity.
AU  - Ravussin, E.
AU  - Fontvieille, A. M.
AU  - Swinburn, B. A.
AU  - Bogardus, C.
A2  - Klimeš, I.
A2  - Howard, B. V.
A2  - Storlien, L. H.
A2  - Šeböková, E.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1993///
VL  - 683
SP  - 141
EP  - 150
SN  - 0077-8923
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19941401018.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - Risk factors for the development of obesity are reviewed, including: components of energy expenditure; risk factors for body weight gain; fat balance vs. energy balance; and implications for treatment.
KW  - body weight
KW  - energy balance
KW  - fats
KW  - obesity
KW  - reviews
KW  - risk
KW  - treatment
KW  - weight gain
KW  - Slovakia
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Dietary Lipids and Insulin Action - Second International Smolenice Insulin Symposium
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrient and food group intake by tobacco use status: the 1987 National Health Interview Survey.
AU  - Subar, A. F.
AU  - Harlan, L. C.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1993///
VL  - 686
SP  - 310
EP  - 322
SN  - 0077-8923
AD  - Subar, A. F.: Applied Research Branch, National Cancer Institute, National Institutes of Health, Executive Plaza North, Room 313, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941402143.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - Data from the 1987 National Health Interview Survey (USA) investigating dietary differences among never, former and current tobacco users is discussed.
KW  - diet studies
KW  - tobacco smoking
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402143&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Carotenoids, cancer, and clinical trials.
AU  - Ziegler, R. G.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1993///
VL  - 691
SP  - 110
EP  - 119
SN  - 0077-8923
AD  - Ziegler, R. G.: Nutritional Epidemiology Section, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North 443, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941405487.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 21 ref. Subject Subsets: Human Nutrition
N2  - Clinical trials of cancer epidemiology and carotenoid intake are reviewed.
KW  - carcinoma
KW  - carotenoids
KW  - diet
KW  - intake
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - tetraterpenoids
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405487&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Laboratory diagnosis of candidiasis.
AU  - Walsh, T. J.
AU  - Pizzo, P. A.
A2  - Bodey, G. P.
T2  - Candidiasis: pathogenesis, diagnosis and treatment.
Y1  - 1993///
IS  - Ed. 2
CY  - New York; USA
PB  - Raven Press
SN  - 0881679542
AD  - Walsh, T. J.: Infectious Disease Section, Department of Pediatrics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200559.  Publication Type: Book chapter.  Language: English.  Number of References: 134 ref. Subject Subsets: Medical & Veterinary Mycology
KW  - blood
KW  - candidosis
KW  - detection
KW  - diagnosis
KW  - fungaemia
KW  - histopathology
KW  - human diseases
KW  - infections
KW  - polymerase chain reaction
KW  - reviews
KW  - serology
KW  - techniques
KW  - Candida
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - candidiasis
KW  - fungemia
KW  - fungus
KW  - Hyphomycetes
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200559&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Fundamental immunology.
A2  - Paul, W. E.
T2  - Fundamental immunology.
Y1  - 1993///
IS  - Ed. 3
CY  - New York; USA
PB  - Raven Press
SN  - 0781700221
AD  - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804963.  Publication Type: Book.  Language: English.  Subject Subsets: Helminthology; Protozoology; Medical & Veterinary Entomology
N2  - This 3rd edition retains the the overall organizational structure of the first edition: one of increasing complexity. It begins with an introductory section dealing with the immune system and a history of immunology. This is followed by 2 sections (which deal with the organization and development of the immune system, and antigens, antibodies and receptors) which deal in detail with key aspects of immunology. The next 4 sections (on lymphocyte activation, proliferation and differentiation, the major histocompatibility complex, regulation of the immune response, and effector mechanisms of immunity) give in-depth discussion of individual topics. The final section covers immunological mechanisms in disease (autoimmunity and autoimmune diseases, transplantation and graft rejection, tumour immunology, immunoparasitology, immunity to viruses, immunity to intracellular bacteria, immunity to extracellular bacteria, vaccines, primary immunodeficiency diseases, immunology of HIV infection, allergy and mechanisms of hypersensitivity). The 40 chapters (each by experts in their fields) provide a wide range of information in this rapidly advancing field.
KW  - helminths
KW  - immunology
KW  - parasites
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - parasitic worms
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
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ER  - 

TY  - GEN
T1  - Giardia lamblia and giardiasis.
AU  - Nash, T. E.
A2  - Warren, K. S.
T2  - Immunology and molecular biology of parasitic infections.
Y1  - 1993///
IS  - Ed. 3
CY  - Oxford; UK
PB  - Blackwell Scientific Publications Ltd
SN  - 0865420955
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930807461.  Publication Type: Book chapter.  Language: English.  Number of References: 149 ref. Subject Subsets: Protozoology
N2  - A short account of the biology of Giardia lamblia [Giardia duodenalis] is followed by discussions of innate resistance, immune responses, humoral responses in humans, cellular immunity in humans, immune responses in G. muris infections, and immunodiagnosis.
KW  - human diseases
KW  - immunology
KW  - parasites
KW  - reviews
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Leishmaniasis.
AU  - Sacks, D. L.
AU  - Louis, J. A.
AU  - Wirth, D. F.
A2  - Warren, K. S.
T2  - Immunology and molecular biology of parasitic infections.
Y1  - 1993///
IS  - Ed. 3
CY  - Oxford; UK
PB  - Blackwell Scientific Publications Ltd
SN  - 0865420955
AD  - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930807464.  Publication Type: Book chapter.  Language: English.  Number of References: 267 ref. Subject Subsets: Protozoology
N2  - A brief discussion of the disease forms of leishmaniasis (cutaneous, mucocutaneous, visceral) is followed by a review of immunodiagnosis, DNA probe-based diagnosis, encounters of Leishmania parasites with the nonimmune vertebrate host (complement, attachments to macrophages, intramacrophage survival), use of molecular biology to understand pathogenesis; immunologic parameters and immunopathologic aspects of human leishmaniasis, animal models of infection with Leishmania, and cellular parameters associated with immunologic unresponsiveness in visceral L. donovani infection.
KW  - human diseases
KW  - immunology
KW  - parasites
KW  - reviews
KW  - Leishmania
KW  - man
KW  - protozoa
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Mechanisms of acquired immunity against parasites.
AU  - Sher, A.
AU  - Scott, P. A.
A2  - Warren, K. S.
T2  - Immunology and molecular biology of parasitic infections.
Y1  - 1993///
IS  - Ed. 3
CY  - Oxford; UK
PB  - Blackwell Scientific Publications Ltd
SN  - 0865420955
AD  - Sher, A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
N1  - Accession Number: 19930807450.  Publication Type: Book chapter.  Language: English.  Number of References: 72 ref. Subject Subsets: Helminthology; Protozoology
N2  - The different manifestations of acquired immunity against parasitic infections are reviewed and the immunological effector mechanisms currently implicated in both naturally acquired and vaccine-induced resistance are discussed. Immunity induced by previous infection, premunition, concomitant immunity, immunity stimulated by inoculation of attenuated parasites, immunization with native or recombinant antigens or peptide epitopes, molecular basis of immune recognition, antibody-dependent effector mechanisms, cell-mediated immunity, regulation of acquired immunity (by antibodies, cells and cytokines), genetic influences on protective immunity and the role of antigen presentation on the induction of protective immune responses against parasites are considered.
KW  - helminths
KW  - human diseases
KW  - immunity
KW  - immunology
KW  - parasites
KW  - reviews
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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ER  - 

TY  - GEN
T1  - The historical road to the discovery of Borrelia burgdorferi.
AU  - Burgdorfer, W.
A2  - Weber, K.
A2  - Burgdorfer, W.
T2  - Aspects of Lyme borreliosis.
JO  - Aspects of Lyme borreliosis.
JF  - Aspects of Lyme borreliosis.
Y1  - 1993///
SP  - 21
EP  - 28
CY  - Berlin; Germany
PB  - Springer-Verlag
SN  - 3540556281\0387556281
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930517483.  Publication Type: Miscellaneous.  Language: English.  Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - history
KW  - Human diseases
KW  - Lyme disease
KW  - research
KW  - Tickborne diseases
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - lyme borreliosis
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Research (AA500) 
KW  - History and Biography (BB500) 
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DB  - lhh
ER  - 

TY  - GEN
T1  - Ultrastructure of Borrelia burgdorferi.
AU  - Hayes, S. F.
AU  - Burgdorfer, W.
A2  - Weber, K.
A2  - Burgdorfer, W.
T2  - Aspects of Lyme borreliosis.
JO  - Aspects of Lyme borreliosis.
JF  - Aspects of Lyme borreliosis.
Y1  - 1993///
SP  - 29
EP  - 43
CY  - Berlin; Germany
PB  - Springer-Verlag
SN  - 3540556281\0387556281
AD  - Hayes, S. F.: Department of Health and Human Services, Public Helath Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1  - Accession Number: 19930517484.  Publication Type: Miscellaneous.  Language: English.  Number of References: 49 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - Electron microscopy
KW  - ultrastructure
KW  - Borrelia burgdorferi
KW  - Spirochaetaceae
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - GEN
T1  - Genome mapping and linkage analysis in Plasmodium falciparum: toward identification of the chloroquine resistance determinant.
AU  - Wellems, T. E.
A2  - Morzaria, S. P.
T2  - Genome analysis of protozoan parasites: Proceedings of a Workshop held at ILRAD, Nairobi, Kenya 11-13 November 1992.
JO  - Genome analysis of protozoan parasites: Proceedings of a Workshop held at ILRAD, Nairobi, Kenya 11-13 November 1992.
JF  - Genome analysis of protozoan parasites: Proceedings of a Workshop held at ILRAD, Nairobi, Kenya 11-13 November 1992.
Y1  - 1993///
SP  - 45
EP  - 53
CY  - Nairobi; Kenya
PB  - International Laboratory for Research on Animal Diseases (ILRAD)
SN  - 9290552964
AD  - Wellems, T. E.: Genetics and Pharmacology Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950801767.  Publication Type: Conference paper.  Language: English.  Number of References: 33 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0.  Subject Subsets: Protozoology
N2  - Chromosome mapping and linkage analysis is reviewed with reference to Plasmodium falciparum and specifically the identification of the chloroquine resistance determinant.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - chloroquine
KW  - drug resistance
KW  - gene mapping
KW  - genome analysis
KW  - parasites
KW  - reviews
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Clinical use of cytokines during fungal infections.
AU  - Roilides, E.
AU  - Walsh, T. J.
AU  - Pizzo, P. A.
A2  - Furth, R. van
T2  - Hemopoietic growth factors and mononuclear phagocytes.
JO  - Hemopoietic growth factors and mononuclear phagocytes.
JF  - Hemopoietic growth factors and mononuclear phagocytes.
Y1  - 1993///
SP  - 90
EP  - 97
CY  - Basel; Switzerland
PB  - S. Karger AG
SN  - 3805556780
AD  - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19931215046.  Publication Type: Miscellaneous.  Language: English.  Number of References: 21 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The pathogenesis of specific fungal infections are discussed, and experimental and clinical studies of the role of cytokines in these infections (due to Candida spp., Aspergillus spp., Histoplasma capsulatum, Cryptococcus neoformans and Trichosporon beigelii) in immunocompromised hosts, are also considered.
KW  - cytokines
KW  - immunology
KW  - immunotherapy
KW  - infections
KW  - Aspergillus
KW  - Candida
KW  - Cryptococcus neoformans
KW  - Histoplasma capsulatum
KW  - Man
KW  - Trichosporon beigelii
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Ajellomyces capsulatus
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - GEN
T1  - In situ kinetics and ascorbic acid requirements.
AU  - Levine, M.
AU  - Cantilena, C. C.
AU  - Dhariwal, K. R.
A2  - Simopoulos, A. P.
T2  - Nutrition and fitness in health and disease.
JO  - Nutrition and fitness in health and disease.
JF  - Nutrition and fitness in health and disease.
Y1  - 1993///
SP  - 114
EP  - 127
CY  - Basel; Switzerland
PB  - S Karger AG
SN  - 380555706X
AD  - Levine, M.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941400757.  Publication Type: Conference paper.  Language: English.  Number of References: 81 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - A review. The optimum amount of ascorbic acid (AA) for man remains unknown. Optimum requirements can be determined by learning how biochemical function is regulated by vitamin concentration, and how those concentrations are achieved in man. Biochemical evidence indicates that this approach is feasible. Clinical evidence is needed to learn whether AA concentrations can be achieved which control biochemical function, and to reveal how AA concentrations are regulated by ingestion. For the first time, these clinical studies are possible. In situ kinetics offers a new approach to achieving optimum requirements for vitamin C, and for other vitamins.
KW  - ascorbic acid
KW  - metabolism
KW  - requirements
KW  - reviews
KW  - Greece
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Balkans
KW  - Southern Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - 2nd International Conference on Nutrition and Fitness
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The search for new pharmaceutical crops: drug discovery and development at the National Cancer Institute.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
AU  - Cardellina, J. H., II
AU  - Grever, M. R.
AU  - Schepartz, S.
AU  - Snader, K. M.
AU  - Suffness, M.
A2  - Janick, J.
A2  - Simon, J. E.
T2  - New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991.
JO  - New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991.
JF  - New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991.
Y1  - 1993///
SP  - 161
EP  - 167
CY  - New York; USA
PB  - John Wiley and Sons, Inc.
SN  - 0471593745
AD  - Cragg, G. M.: Natural Products Branch, National Cancer Institute, Frederick Cancer R&D Center, Frederick, Maryland 21702, USA.
N1  - Accession Number: 19960303212.  Publication Type: Conference paper.  Language: English.  Number of References: 13 ref. Registry Number: 33069-62-4.  Subject Subsets: Botanical Pesticides; Horticultural Science
N2  - Past and present activities at the United States National Cancer Institute are discussed in 3 sections: Plant acquisition programme; Drug discovery and development (in particular, screening for cytotoxicity and anti-HIV activity); and Large-scale production of taxol (covering early development of taxol, isolated from Taxus brevifolia, current status of taxol development, and alternative sources of taxol).
KW  - anticancer properties
KW  - antineoplastic agents
KW  - antiviral properties
KW  - cytotoxicity
KW  - diterpenoid alkaloids
KW  - drugs
KW  - medicinal plants
KW  - paclitaxel
KW  - pharmacology
KW  - plant composition
KW  - production
KW  - research
KW  - screening
KW  - USA
KW  - Taxus
KW  - Taxus brevifolia
KW  - Taxaceae
KW  - Taxopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Taxus
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - anti-cancer properties
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - cytotoxic agents
KW  - drug plants
KW  - human immunodificiency virus
KW  - medicinal herbs
KW  - medicines
KW  - New crops: exploration, research and commercialization
KW  - officinal plants
KW  - pharmaceuticals
KW  - screening tests
KW  - studies
KW  - taxol
KW  - United States of America
KW  - Plant Composition (FF040) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Non-food/Non-feed Plant Products (SS200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Sporogonic development of malaria parasites in mosquitoes and in vitro.
AU  - Warburg, A.
A2  - Borovsky, D.
A2  - Spielman, A.
T2  - Host regulated developmental mechanisms in vector arthropods: Proceedings of the Third Symposium, Vero Beach, Florida, February 8-11, 1993.
JO  - Host regulated developmental mechanisms in vector arthropods: Proceedings of the Third Symposium, Vero Beach, Florida, February 8-11, 1993.
JF  - Host regulated developmental mechanisms in vector arthropods: Proceedings of the Third Symposium, Vero Beach, Florida, February 8-11, 1993.
Y1  - 1993///
SP  - 234
EP  - 239
CY  - Vero Beach, Florida; USA
PB  - University of Florida - IFAS, Florida Medical Entomology Laboratory
SN  - 0961522445
AD  - Warburg, A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B2-37, Bethesda, MD 20892, USA.
N1  - Accession Number: 19930517463.  Publication Type: Conference paper.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
KW  - development
KW  - Disease vectors
KW  - in vitro
KW  - Infections
KW  - parasites
KW  - Sporogony
KW  - Sporozoites
KW  - Aedes aegypti
KW  - Anopheles
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - Aquatic Biology and Ecology (MM300) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The role of plants in the drug discovery program of the United States National Cancer Institute.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
AU  - Cardellina, J. H., II
AU  - Grever, M. R.
AU  - Schepartz, S. A.
AU  - Snader, K. M.
A2  - Buxton, D. R.
A2  - Shibles, R.
A2  - Forsberg, R. A.
A2  - Blad, B. L.
A2  - Asay, K. H.
A2  - Paulsen, G. M.
A2  - Wilson, R. F.
T2  - International crop science I. International Crop Science Congress, Ames, Iowa, USA, 14-22 July 1992.
JO  - International crop science I. International Crop Science Congress, Ames, Iowa, USA, 14-22 July 1992.
JF  - International crop science I. International Crop Science Congress, Ames, Iowa, USA, 14-22 July 1992.
Y1  - 1993///
SP  - 465
EP  - 472
CY  - Madison, WI; USA
PB  - Crop Science Society of America
SN  - 0891185380
AD  - Cragg, G. M.: Natural Products Branch, Developmental Therapeutics Program, National Cancer Institute, Suite 206, Fairview Center, PO Box B, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19941607939.  Publication Type: Conference paper.  Language: English.  Number of References: 38 ref. Registry Number: 33069-62-4.  Subject Subsets: Plant Genetic Resources
N2  - A systematic effort to collect and screen plants for pharmaceutical (anti-cancer) properties was initiated in 1960 by the National Cancer Institute (NCI) in collaboration with the USDA. By 1982, 35 000 collections had been made in over 60 countries in the temperate regions. Although this research was discontinued because few novel active agents were being isolated, the development of a new screen led to the programme's resumption in 1986. Since 1988, following the development of a high-flux anti-HIV screen, the programme has been extended to anti-AIDS testing of plant materials. This paper examines the research with reference to those plant materials which have advanced to clinical trials, under the following headings: (1) status of plant-derived anti-cancer agents; (2) NCI plant collection programme from 1986 to the present; (3) natural product drug discovery and development; (4) drug development and supply issues; (5) large scale production of taxol; (6) large scale production of biomass: NCI policies; (7) plant-derived agents: recent NCI discoveries; and (8) international collaboration and compensation (NCI letter of intent and programme expansion to tropical countries).
KW  - acquired immune deficiency syndrome
KW  - antineoplastic agents
KW  - drugs
KW  - genetic resources
KW  - human immunodeficiency viruses
KW  - international agreements
KW  - international cooperation
KW  - medicinal properties
KW  - neoplasms
KW  - paclitaxel
KW  - pharmaceutical products
KW  - plant genetic resources
KW  - screening
KW  - temperate zones
KW  - USA
KW  - plants
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cancers
KW  - cytotoxic agents
KW  - gene resources
KW  - human immunodeficiency virus
KW  - International Crop Science I
KW  - medicines
KW  - pharmaceuticals
KW  - screening tests
KW  - taxol
KW  - United States of America
KW  - Biological Resources (Plant) (PP720) 
KW  - Plant Composition (FF040) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-food/Non-feed Plant Products (SS200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941607939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Dietary antigens and regulation of the mucosal immune response.
AU  - Strober, W.
A2  - Cunningham-Rundles, S.
T2  - Nutrient modulation of the immune response.
JO  - Nutrient modulation of the immune response.
JF  - Nutrient modulation of the immune response.
Y1  - 1993///
SP  - 533
EP  - 540
CY  - New York; USA
PB  - Marcel Dekker, Inc.
SN  - 0824784480
AD  - Strober, W.: National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19931466586.  Publication Type: Miscellaneous.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - Dietary antigens and regulation of the mucosal immune response are reviewed.
KW  - antigens
KW  - food allergies
KW  - foods
KW  - immune response
KW  - mucosa
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - food hypersensitivity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - mucous membrane
KW  - Host Resistance and Immunity (HH600) 
KW  - Food Science and Food Products (Human) (QQ000) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466586&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Growth factors and malignant transformation.
AU  - Aaronson, S. A.
AU  - Miki, T.
AU  - Meyers, K.
AU  - Chan, A.
A2  - Zappia, V.
A2  - Salvatore, M.
A2  - Ragione, F. D.
T2  - Advances in nutrition and cancer.
Y1  - 1993///
CY  - New York; USA
PB  - Plenum Publishing Corporation
SN  - 0306446707
AD  - Aaronson, S. A.: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941410232.  Publication Type: Book chapter.  Language: English.  Number of References: 85 ref. Subject Subsets: Human Nutrition
N2  - This review is introduced by referring to the convergence of research aimed at identifying the functions of retroviral oncogenes with investigations of normal mitogenic signalling by growth factors. The subject is covered under the headings: Growth factor requirements for cell proliferation; Receptor tyrosine kinases and their effectors; Oncogene subversion of specific signalling pathways; Implication of other mitogenic signalling systems in malignancy; Expression cloning of growth regulatory genes; Expression cloning of a transforming gene from a human sarcoma cDNA library; Transforming properties of Gα12; and Overexpression of wild-type Gα12 is sufficient for transformation.
KW  - cell growth
KW  - growth factors
KW  - neoplasms
KW  - oncogenes
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cell elongation
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Genetics (General and Theoretical) (ZZ370) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410232&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The invasion of erythrocytes by malarial merozoites.
AU  - Ward, G. E.
AU  - Chitnis, C. E.
AU  - Miller, L. H.
A2  - Russell, D. G.
JO  - Bailliere's Clinical Infectious Diseases
JF  - Bailliere's Clinical Infectious Diseases
Y1  - 1994///
VL  - 1
IS  - 2
SP  - 155
EP  - 190
AD  - Ward, G. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805277.  Publication Type: Journal Article.  Language: English.  Number of References: 179 ref. Subject Subsets: Protozoology
N2  - This review summarizes what is currently known about the mechanisms underlying the invasion of erythrocytes by Plasmodium merozoites under the headings: experimental systems for studying invasion (receptor-ligand studies, other aspects of invasion); apical organelles (rhoptries, micronemes, dense granules); merozoite plasma membrane; proteases; steps in invasion (receptor-ligand interactions, signal transduction, parasitophorous vacuole formation, parasite entry). Future prospects are discussed.
KW  - cell invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - human diseases
KW  - parasites
KW  - reviews
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - blood red cells
KW  - parasite host relationships
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805277&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A conformational epitope on the dimer of the fusion protein of respiratory syncytial virus detected in natural infections.
AU  - Subbarao, E. K.
AU  - Beeler, J. A.
AU  - Waner, J. L.
JO  - Clinical and Diagnostic Virology
JF  - Clinical and Diagnostic Virology
Y1  - 1994///
VL  - 1
IS  - 5/6
SP  - 313
EP  - 323
SN  - 0928-0197
AD  - Subbarao, E. K.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942026925.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A murine monoclonal antibody (MAb), 2D8, was used in immunofluorescence reactions to detect respiratory syncytial virus (RSV) antigen in clinical specimens. Nasopharyngeal epithelial cells from 63 of 66 children with RSV infections reacted with this MAb. The MAb was further characterized and was demonstrated to recognize a conformational epitope on the dimer of the fusion protein of RSV. No reaction was detected with the MAb, 2D8, on Western blots of antigen prepared from RSV-infected HEp-2 cells under reducing conditions. Under non-reducing conditions, 2D8 reacted with a 145-170 K protein; this reactivity was lost when the antigen preparation was heated to 100 °C, 2D8 reacted with purified F glycoprotein of RSV Long in an ELISA, neutralized infectivity of RSV by &gt;50% at a dilution of 1:500, and was able to inhibit cell-to-cell fusion of RSV-infected cells. In a competitive ELISA, the epitope detected by 2D8 was localized to antigenic site A. The conformational epitope detected by 2D8 required protein dimerization and glycosylation for full reactivity. This report extends previous characterizations of the F protein in its native state in that the MAb defines a conformational epitope on the fusion protein dimer that is expressed in natural infections and elicits antibody that can neutralize virus infectivity and inhibit cell-to-cell fusion. In addition to its application as a diagnostic reagent, this MAb can be of use in testing preparations of RSV or purified F protein in which the purification or extraction processes could have destroyed conformational epitopes. AS
KW  - diagnosis
KW  - infections
KW  - monoclonal antibodies
KW  - North America
KW  - Oklahoma
KW  - USA
KW  - human respiratory syncytial virus
KW  - Pneumovirus
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Pneumovirinae
KW  - viruses
KW  - America
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - Southern Plains States of USA
KW  - West South Central States of USA
KW  - Southern States of USA
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026925&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of Japanese encephalitis virus antigens in the CSF using monoclonal antibodies.
AU  - Desai, A.
AU  - Chandramuki, A.
AU  - Gourie-Devi, M.
AU  - Ravi, V.
JO  - Clinical and Diagnostic Virology
JF  - Clinical and Diagnostic Virology
Y1  - 1994///
VL  - 2
IS  - 3
SP  - 191
EP  - 199
SN  - 0928-0197
AD  - Desai, A.: Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India.
N1  - Accession Number: 19952005554.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 308067-57-4.  Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2  - Samples obtained from 115 patients with a clinical diagnosis of Japanese encephalitis (JE) were used to evaluate 2 monoclonal antibody-based detection methods. The results were compared to the detection of IgM antibodies in the CSF. The diagnostic tests used were a reverse passive haemagglutination test for the detection of soluble JEV antigens, an immunofluorescent assay for the detection of cell-associated antigen and an IgM capture ELISA for the detection of virus specific IgM antibodies in the CSF. Laboratory confirmation of JE was possible in 92/115 patients. Virus-specific IgM was detected in 75/92 and JEV antigen was detected in 52/92 patients. Soluble antigen was detected in 37/52, cell-associated antigen in 30/52. There was no significant difference in the sensitivity of the 2 antigen detection systems used. Diagnosis by antigen detection could be done less frequently than by demonstration of virus-specific IgM antibodies in the spinal fluid. However, antigen detection proved useful during the first week of illness when IgM antibodies were not detected in the CSF.
KW  - arboviruses
KW  - cerebrospinal fluid
KW  - diagnosis
KW  - ELISA
KW  - fluorescence
KW  - haemagglutination tests
KW  - human diseases
KW  - IgM
KW  - immunodiagnosis
KW  - immunoglobulins
KW  - Japanese encephalitis
KW  - monoclonal antibodies
KW  - nervous system diseases
KW  - Asia
KW  - India
KW  - Japanese encephalitis virus
KW  - man
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - arthropod-borne viruses
KW  - enzyme linked immunosorbent assay
KW  - gamma-globulins
KW  - hemagglutination tests
KW  - immune globulins
KW  - neuropathy
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rotavirus vaccine development for the prevention of severe diarrhoea in infants and young children.
AU  - Hoshino, Y.
AU  - Kapikian, A. Z.
JO  - Trends in Microbiology
JF  - Trends in Microbiology
Y1  - 1994///
VL  - 2
IS  - 7
SP  - 242
EP  - 249
SN  - 0966-842X
AD  - Hoshino, Y.: Epidemiology Section, Laboratory of the Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008531.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref.
KW  - children
KW  - diarrhoea
KW  - human diseases
KW  - immunization
KW  - infants
KW  - vaccine development
KW  - man
KW  - rotavirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - diarrhea
KW  - immune sensitization
KW  - scouring
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008531&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evolving patterns of nosocomial and community-acquired deep mycoses: analogies to other infections and implications for practitioners.
AU  - Walsh, T. J.
JO  - Infectious Diseases in Clinical Practice
JF  - Infectious Diseases in Clinical Practice
Y1  - 1994///
VL  - 3
IS  - Suppl. 2
SP  - S103
EP  - S112
SN  - 1056-9103
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941202160.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 107 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The changing patterns in the epidemiology, diagnosis and treatment of nosocomial and community-acquired deep mycoses are reviewed and several analogies are drawn between nosocomial fungal infections and nosocomial bacterial infections, as these 2 types of infection relate to changes in the hosts and antimicrobial pressures. Epidemiological implications for vaccine development, the role of the clinical mycology laboratory as a critical interface between bedside diagnosis and therapeutic intervention, and development of antifungal compounds are also discussed.
KW  - antifungal agents
KW  - diagnosis
KW  - drug therapy
KW  - epidemiology
KW  - human diseases
KW  - mycoses
KW  - nosocomial infections
KW  - therapy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - evolving etiologies of invasive mycoses
KW  - fungistats
KW  - hospital infections
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Second International Conference on Cryptococcus and Cryptococcosis, Milan (Italy), September 19-23, 1993. Closing address.
AU  - Bennett, J. E.
JO  - Journal de Mycologie Médicale
JF  - Journal de Mycologie Médicale
Y1  - 1994///
VL  - 4
IS  - 2
SP  - 125
EP  - 127
SN  - 1156-5233
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19941201398.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Recent research advances in Cryptococcus neoformans infections that were presented at this conference are summarized. Cell mediated and humoral immunity mechanisms, molecular biology and gene cloning techniques, and the epidemiology of cryptococcosis are discussed.
KW  - epidemiology
KW  - genetics
KW  - immunology
KW  - research
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - 2nd International conference on Cryptococcus and cryptococcosis
KW  - fungus
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201398&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - Treatment and developmental therapeutics of Mycobacterium tuberculosis infections.
AU  - Georgiev, V. S.
JO  - International Journal of Antimicrobial Agents
JF  - International Journal of Antimicrobial Agents
Y1  - 1994///
VL  - 4
IS  - 3
SP  - 157
EP  - 173
SN  - 0924-8579
AD  - Georgiev, V. S.: National Institute of Allergy and Infectious Diseases, NIH, Solar Building, Room 4C-04, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952000738.  Publication Type: Journal Article.  Language: English.  Number of References: 169 refs. Subject Subsets: Public Health
N2  - A review article which discusses the incidence of tuberculosis and both current and novel methods of treatment.
KW  - drug therapy
KW  - human diseases
KW  - new drugs
KW  - reviews
KW  - tuberculosis
KW  - man
KW  - Mycobacterium tuberculosis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - chemotherapy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000738&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intracellular susceptibility to ribozymes in a tethered substrate-ribozyme provirus model is not predicted by secondary structures of human immunodeficiency virus type 1 RNAs in vitro.
AU  - Dropulic´, B.
AU  - Jeang, K. T.
JO  - Antisense Research and Development
JF  - Antisense Research and Development
Y1  - 1994///
VL  - 4
IS  - 3
SP  - 217
EP  - 221
SN  - 1050-5261
AD  - Dropulic´, B.: (K.T. Jeang) Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050970.  Publication Type: Journal Article.  Language: English.  Registry Number: 63231-63-0. 
KW  - antiviral agents
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - RNA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - ribonucleic acid
KW  - ribozymes
KW  - secondary structure
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050970&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol consumption during pregnancy and infant birth weight.
AU  - Faden, V. B.
AU  - Graubard, B. I.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1994///
VL  - 4
IS  - 4
SP  - 279
EP  - 284
SN  - 1047-2797
AD  - Faden, V. B.: Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, 5600 Fishers Lane, Room 14C26, Rockville, MD 20857, USA.
N1  - Accession Number: 19951406765.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - Data for the study were gathered as part of the National Longitudinal Survey of Youth, a multistage, stratified, clustered probability sample of housing units drawn to be representative of the population of young persons in the USA. Of the 4409 births remaining in the sample after multiple births and subjects with incomplete information were eliminated, alcohol drinking was reported by 1506 mothers during pregnancy and no drinking by 2903. Consumption of alcohol less than once a month was reported for 738, about once a month for 362, 3 to 4 times a month for 208, once or twice weekly for 1248, 3 to 4 times weekly for 32 and every day or nearly every day for 18 women during pregnancy. Multiple linear regression and logistic regression were used to adjust the relation between drinking and birth weight for relevant covariates. There was a non-significant trend in the direction of greater numbers of babies of low birth born to mothers who consumed alcoholic beverages more frequently during pregnancy. There was an interaction between drinking alcoholic beverages and smoking in which the negative effects on birth weight of smoking were less for those women who drank more heavily (P=0.046).
KW  - alcoholic beverages
KW  - birth weight
KW  - intake
KW  - mothers
KW  - neonates
KW  - pregnancy
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - gestation
KW  - newborn infants
KW  - United States of America
KW  - Human Reproduction and Development (VV060) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Radon exposure in residences and lung cancer among women: combined analysis of three studies.
AU  - Lubin, J. H.
AU  - Liang, Z. H.
AU  - et al.
AU  - Hrubec, Z. (
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1994///
VL  - 5
IS  - 2
SP  - 114
EP  - 128
SN  - 0957-5243
AD  - Lubin, J. H.: Biostatistics Branch, National Cancer Institute, Executive Plaza North, Room 403, 6130 Executive Blvd, Rockville, MD 20852, USA.
N1  - Accession Number: 19942050319.  Publication Type: Journal Article.  Language: English.  Registry Number: 10043-92-2.  Subject Subsets: Public Health; Tropical Diseases
N2  - Lung cancer risk in relation to indoor radon was examined in three case-control studies in Stockholm (Sweden), New Jersey (United States), and Shenyang (People's Republic of China). Year-long measurements of radon gas were made in current and past homes of 966 women who developed lung cancer and of 1158 control women, included in the combined analysis. Nearly 14% of the participants were estimated to have a time-weighted, mean, radon concentration in their homes of more than 4 pCi/1 (150 Bq/m³) during the period from five to 35 years prior to the date of lung cancer diagnosis (or comparable date for controls). There was a tendency for risk to increase with increasing levels of radon in NJ and Stockholm, but the trends for individual studies and overall were not statistically significant. The estimates of the excess relative risk for indoor exposure per pCi/l were 0.18 (95% [CI] = 0.04-0.70) in NJ, 0.06 (CI = 0.05-0.34) in Stockholm, and -0.02 (CI = -χ-0.03) for Shenyang; these estimates did not differ significantly from each other. The overall excess RR per pCi/l was 0.00 (CI = 0.05-0.07); the confidence limits were sufficiently broad, however, that the overall estimate was still compatible with extrapolations of risks from miners. Cigarette smoking was the predominant cause of lung cancer with the RR significantly elevated in all studies. Within smoking categories, the trend in risk with increasing mean radon concentration was inconsistent. Analyses of data from several studies are complicated by the possibility that there may exist important differences in study bases which might affect results, and which may be controlled only partially through adjustment procedures. Future efforts to combine various residential studies will need to be attentive to the intrinsic limitations of studies to detect low levels of risk as well as the unique uncertainties associated with estimating, accurately, cumulative exposure to indoor radon. AS
KW  - comparisons
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - radon
KW  - risk factors
KW  - Toxicology
KW  - women
KW  - Asia
KW  - China
KW  - Europe
KW  - New Jersey
KW  - North America
KW  - Sweden
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - European Union Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancer sites
KW  - cancers
KW  - People's Republic of China
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050319&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occupation, physical activity, and risk of prostate cancer in Shanghai, People's Republic of China.
AU  - Hsing, A. W.
AU  - McLaughlin, J. K.
AU  - Zheng, W.
AU  - Gao, Y. T.
AU  - Blot, W. J.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1994///
VL  - 5
IS  - 2
SP  - 136
EP  - 140
SN  - 0957-5243
AD  - Hsing, A. W.: Division of Cancer Etiology, Epidemiology and Biostatistics Program, National Cancer Institute, EPN 415, 6130 Executive Blvd., Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050316.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Based on occupational data for all (n = 264) prostate cancer cases diagnosed during 1980-84 in urban Shanghai and on employment information from the 1982 census, standardized incidence ratios (SIR) were calculated for occupational groups classified by job type and physical activity level. White-collar workers (professionals, government officials, clerical workers, salespersons) had an elevated incidence of prostate cancer, although the excesses were not significant. In addition, when jobs were classified by time spent sitting or energy expenditure, men employed in occupations with low physical activity levels tended to have moderately elevated risks of prostate cancer. Findings from this study in an area with one of the world's lowest incidence rates of prostate cancer add to the accumulating evidence that jobs with a low level of physical activity are associated with an increased prostate-cancer risk. AS
KW  - neoplasms
KW  - prostate
KW  - prostate cancer
KW  - risk factors
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - People's Republic of China
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A case-control interview study of breast cancer among Japanese A-bomb survivors. I. Main effects.
AU  - Land, C. E.
AU  - Hayakawa, N.
AU  - Machado, S. G.
AU  - Yamada, Y.
AU  - Pike, M. C.
AU  - Akiba, S.
AU  - Tokunaga, M.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1994///
VL  - 5
IS  - 2
SP  - 157
EP  - 165
SN  - 0957-5243
AD  - Land, C. E.: Radiation Epidemiology Branch, National Cancer Institute 6130 Rockville Pike, EPN 408, Rockville, MD 20852, USA.
N1  - Accession Number: 19952000633.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Women with breast cancer (cases = 196) and without the disease (controls = 566), selected from the Life Span Study sample of A-bomb survivors and non-exposed residents of Hiroshima and Nagasaki, Japan, and matched on age at the time of the bombings, city, and estimated radiation dose, were interviewed about reproductive and medical history. A primary purpose of the study was to identify strong breast cancer risk factors that could be investigated further for possible interactions with radiation dose. As expected, age at first full-term pregnancy was strongly and positively related to risk. Inverse associations were observed with number of births and total, cumulative period of breast feeding, even after adjustment for age at first full-term pregnancy. Histories of treatment for dysmenorrhoea and for uterine or ovarian surgery were associated positively and significantly with risk at ages 55 or older, a finding that requires additional study. Other factors related to risk at older ages were the Quetelet index (weight [kg]/height [cm]²) at age 50, history of thyroid disease, and hypertension. Neither age at menarche nor age at menopause was associated significantly with risk. Subjects appeared to be poorly informed about history of breast cancer or other cancer in themselves or in their close relatives; this finding suggests that innovative strategies may be required when studying familial cancer patterns in Japanese populations. AS/Danielle Horton
KW  - breast
KW  - breast cancer
KW  - eyes
KW  - human diseases
KW  - neoplasms
KW  - radiation
KW  - risk factors
KW  - Asia
KW  - Japan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000633&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A case-control interview study of breast cancer among Japanese A-bomb survivors. II. Interactions with radiation dose.
AU  - Land, C. E.
AU  - Hayakawa, N.
AU  - Machado, S. G.
AU  - Yamada, Y.
AU  - Pike, M. C.
AU  - Akiba, S.
AU  - Tokunaga, M.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1994///
VL  - 5
IS  - 2
SP  - 167
EP  - 176
SN  - 0957-5243
AD  - Land, C. E.: Radiation Epidemiology Branch, National Cancer Institute, 6130 Rockville Pike, EPN 408, Rockville, MD 20852, USA.
N1  - Accession Number: 19952000634.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Three breast cancer risk factors were evaluated in terms of their interactions with radiation dose in a case-control interview study of Japanese A-bomb survivors. Cases and controls were matched on age at the time of the bombings and radiation dose, and dose-related risk was estimated from cohort rather than case-control data. Each factor-age at first full-term pregnancy, number of deliveries, and cumulative lactation period summed over births-confirmed reasonably well to a multiplicative interaction model with radiation dose (the additive interactive model, in which the absolute excess risk associated with a factor is assumed to be independent of radiation dose, was rejected). An important implication of the finding is that early age at first full-term pregnancy, multiple births, and lengthy cumulative lactation are all protective against radiation-related, as well as baseline, breast cancer. Analyses by age at exposure to radiation suggest that, among women exposed to radiation in childhood or adolescence, a first full-term pregnancy at an early age following exposure may be protective against radiation-related risk. AS/Danielle Horton
KW  - breast
KW  - breast cancer
KW  - human diseases
KW  - neoplasms
KW  - radiation
KW  - risk factors
KW  - Asia
KW  - Japan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000634&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differences in reported food frequency by season of questionnaire administration: the 1987 National Health Interview Survey.
AU  - Subar, A. F.
AU  - Frey, C. M.
AU  - Harlan, L. C.
AU  - Kahle, L.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1994///
VL  - 5
IS  - 2
SP  - 226
EP  - 233
SN  - 1044-3983
AD  - Subar, A. F.: National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, MD, USA.
N1  - Accession Number: 19941409357.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - Seasonal reporting in a 59-item food frequency questionnaire (FFQ) administered throughout 1 year using data from the 1987 National Health Interview Survey in the USA (n=20 143 adults) was assessed. Few meaningful differences were found in the proportion of individuals reporting rarely or never consuming a food by season of questionnaire administration. Seasonal reporting bias is evident in FFQs, however, and appears to be due to reporting most recent consumption. Using gender-specific median servings/week, an analysis using logistic regression showed that the estimated proportion of individuals reporting food intake at greater than the yearly median differed between any 2 seasons by at least 5% of the population for 22 foods. Gender specific quintiles of selected nutrients/food groups for the whole year and each season were compared; these showed that quintile assignment never varied by more than 1 adjacent quintile. The most frequent shift in quintile assignment, involving as many as 18.5% of women in the summer, occurred for citrus fruits. The intake biases are small and do not greatly affect population estimates if the FFQ is administered in all seasons, but they may somewhat affect classification of individuals into quantiles for some foods/nutrients.
KW  - adults
KW  - diet studies
KW  - diet study techniques
KW  - questionnaires
KW  - seasonal variation
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - seasonal changes
KW  - seasonal fluctuations
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409357&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Erythropoietin for zidovudine-associated anemia in children with HIV infection.
AU  - Mueller, B. U.
AU  - Jacobsen, F.
AU  - Jarosinski, P.
AU  - Lewis, L. L.
AU  - Pizzo, P. A.
JO  - Pediatric AIDS and HIV Infection
JF  - Pediatric AIDS and HIV Infection
Y1  - 1994///
VL  - 5
IS  - 3
SP  - 169
EP  - 173
SN  - 1045-5418
AD  - Mueller, B. U.: Pediatric Branch, National Cancer Institute, Bethesda, Maryland.
N1  - Accession Number: 19942007234.  Publication Type: Journal Article.  Language: English.  Registry Number: 11096-26-7, 30516-87-1. 
KW  - Adverse effects
KW  - Anaemia
KW  - Children
KW  - Erythropoietin
KW  - HIV infections
KW  - Transfusion
KW  - Treatment
KW  - Zidovudine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - anemia
KW  - AZT
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007234&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiretroviral therapy for infection due to human immunodeficiency virus in children.
AU  - Pizzo, P. A.
AU  - Wilfert, C.
JO  - Pediatric AIDS and HIV Infection
JF  - Pediatric AIDS and HIV Infection
Y1  - 1994///
VL  - 5
IS  - 5
SP  - 273
EP  - 295
SN  - 1045-5418
AD  - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952007930.  Publication Type: Journal Article.  Language: English.  Number of References: 178 ref.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - children
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007930&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokines and HIV infection.
AU  - Shearer, G. M.
AU  - Clerici, M.
AU  - Lucey, D. R.
JO  - Seminars in Virology
JF  - Seminars in Virology
Y1  - 1994///
VL  - 5
IS  - 6
SP  - 449
EP  - 455
SN  - 1044-5773
AD  - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002213.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref.
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - reviews
KW  - viral diseases
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002213&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene therapy for human immunodeficiency virus infection: genetic antiviral strategies and targets for intervention.
AU  - Dropulic´, B.
AU  - Jeang, K. T.
JO  - Human Gene Therapy
JF  - Human Gene Therapy
Y1  - 1994///
VL  - 5
IS  - 8
SP  - 927
EP  - 939
SN  - 1043-0342
AD  - Dropulic´, B.: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952004061.  Publication Type: Journal Article.  Language: English.  Number of References: 118 ref. Registry Number: 9007-49-2, 63231-63-0. 
KW  - antiviral agents
KW  - DNA
KW  - gene therapy
KW  - human immunodeficiency viruses
KW  - RNA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004061&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tracking HIV during disease progression.
AU  - Pantaleo, G.
AU  - Fauci, A. S.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1994///
VL  - 6
IS  - 4
SP  - 600
EP  - 604
SN  - 0952-7915
AD  - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Building 10, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942007148.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - disease course
KW  - HIV infections
KW  - Pathology
KW  - AIDS
KW  - disease progression
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007148&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficacy trials of AIDS vaccines: how science can inform ethics.
AU  - Fast, P. E.
AU  - Mathieson, B. J.
AU  - Schultz, A. M.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1994///
VL  - 6
IS  - 5
SP  - 691
EP  - 697
SN  - 0952-7915
AD  - Fast, P. E.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050727.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - immune response
KW  - immunology
KW  - safety
KW  - vaccines
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050727&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Improvements in the lab diagnosis of PCP.
AU  - Cartwright, C. P.
AU  - Gill, V. J.
JO  - AIDS Clinical Care
JF  - AIDS Clinical Care
Y1  - 1994///
VL  - 6
IS  - 10
SP  - 79
EP  - 79, 81, 88
SN  - 1043-1543
AD  - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19952005202.  Publication Type: Journal Article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - bronchoalveolar lavage
KW  - clinical aspects
KW  - diagnosis
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - opportunistic infections
KW  - Pneumocystis carinii pneumonia
KW  - polymerase chain reaction
KW  - prophylaxis
KW  - sputum
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005202&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The human filariases: new understandings, new therapeutic strategies.
AU  - Ottesen, E. A.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1994///
VL  - 7
IS  - 5
SP  - 550
EP  - 558
SN  - 0951-7375
AD  - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803973.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - This review covers: the parasite and its diagnosis; pathogenesis and clinical understanding (lymphatic filariasis, onchocerciasis); treatment and control (lymphatic filariasis, onchocerciasis, loiasis, post-treatment reactions).
KW  - diagnosis
KW  - drug therapy
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - parasites
KW  - reviews
KW  - Brugia malayi
KW  - Loa loa
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Loa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - Wuchereria
KW  - African eyeworm
KW  - chemotherapy
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803973&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunoglobulin class and subclass antibodies to HIV proteins in maternal serum: association with perinatal transmission.
AU  - Mann, D. L.
AU  - Hamlin-Green, G.
AU  - Willoughby, A.
AU  - Landesman, S. H.
AU  - Goedert, J. J.
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1994///
VL  - 7
IS  - 6
SP  - 617
EP  - 622
SN  - 0894-9255
AD  - Mann, D. L.: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Room 21-78, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19942006722.  Publication Type: Journal Article.  Language: English. 
KW  - Antibodies
KW  - HIV infections
KW  - human immunodeficiency virus infections
KW  - Isotype
KW  - Perinatal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006722&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The drugs 2′,3′-dideoxyinosine (ddI) and 2′,3′-dideoxycytidine (ddC) are safe alternatives in people with AIDS with zidovudine-induced myopathy.
AU  - Jay, C.
AU  - Ropka, M.
AU  - Dalakas, M. C.
T2  - Journal of Acquired Immune Deficiency Syndromes
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1994///
VL  - 7
IS  - 6
SP  - 630
EP  - 631
SN  - 0894-9255
AD  - Jay, C.: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19942006727.  Publication Type: Correspondence.  Language: English.  Registry Number: 69655-05-6, 7841-89-2, 30516-87-1. 
KW  - Adverse effects
KW  - Didanosine
KW  - Dideoxycytidine
KW  - HIV infections
KW  - muscular diseases
KW  - Treatment
KW  - Zidovudine
KW  - adverse reactions
KW  - AZT
KW  - dideoxyinosine
KW  - human immunodeficiency virus infections
KW  - myopathy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006727&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heterosexual transmission of human immunodeficiency virus type 1 from transfusion recipients to their sex partners.
AU  - O'Brien, T. R.
AU  - Busch, M. P.
AU  - et al.
AU  - Donegan, E. (
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1994///
VL  - 7
IS  - 7
SP  - 705
EP  - 710
SN  - 0894-9255
AD  - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Executive Plaza North Building, Room 434, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19942006868.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Heterosexual transmission
KW  - HIV infections
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - Transfusion recipients
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006868&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cigarette smoking, premature rupture of membranes, and vertical transmission of HIV-1 among women with low CD4+ levels.
AU  - Burns, D. N.
AU  - Landesman, S.
AU  - et al.
AU  - Muenz, L. R. (
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1994///
VL  - 7
IS  - 7
SP  - 718
EP  - 726
SN  - 0894-9255
AD  - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Suite 4B11, Rockville, MD 20852, USA.
N1  - Accession Number: 19942006888.  Publication Type: Journal Article.  Language: English. 
KW  - HIV infections
KW  - Maternal transmission
KW  - Pregnancy
KW  - Risk factors
KW  - Smoking
KW  - CD4+ lymphocyte counts
KW  - gestation
KW  - human immunodeficiency virus infections
KW  - mother to child transmission
KW  - Premature rupture of membranes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006888&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Improved detection of HTLV-II antibody using a whole viral lysate-based EIA.
AU  - Kline, R. L.
AU  - Vlahov, D.
AU  - Quinn, T. C.
T2  - Journal of Acquired Immune Deficiency Syndromes
JO  - Journal of Acquired Immune Deficiency Syndromes
JF  - Journal of Acquired Immune Deficiency Syndromes
Y1  - 1994///
VL  - 7
IS  - 12
SP  - 1291
EP  - 1292
SN  - 0894-9255
AD  - Kline, R. L.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19952005341.  Publication Type: Correspondence.  Language: English.  Number of References: 9 ref.
KW  - ELISA
KW  - HTLV-I infections
KW  - HTLV-II infections
KW  - laboratory tests
KW  - serology
KW  - enzyme linked immunosorbent assay
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005341&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current status of prophylaxis for opportunistic infections in HIV-infected patients.
AU  - Decker, C. F.
AU  - Masur, H.
JO  - AIDS
JF  - AIDS
Y1  - 1994///
VL  - 8
IS  - 1
SP  - 11
EP  - 20
SN  - 0269-9370
AD  - Decker, C. F.: (H. Masur) Critical Care Medicine Department, Clinical Center, Building 10 7D43, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005960.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - HIV infections
KW  - Opportunistic infections
KW  - Prophylaxis
KW  - Treatment
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005960&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The use of the flarephotometry in the detection of cytomegalic virus retinitis in AIDS patients.
AU  - Nussenblatt, R. B.
AU  - De Smet, M.
AU  - et al.
AU  - Podgor, M. (
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1994///
VL  - 8
IS  - 1
SP  - 135
EP  - 136
SN  - 0269-9370
AD  - Nussenblatt, R. B.: National Eye Institute, National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005982.  Publication Type: Correspondence.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Cytomegalovirus retinitis
KW  - Diagnosis
KW  - AIDS
KW  - Flare photometry
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005982&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The differential cytotoxicity of cardenolides from Thevetia ahouia.
AU  - Decosterd, L.
AU  - Gustafson, K. R.
AU  - Cardellina, J. H., II
AU  - Cragg, G. M.
AU  - Boyd, M. R.
JO  - Phytotherapy Research
JF  - Phytotherapy Research
Y1  - 1994///
VL  - 8
IS  - 2
SP  - 74
EP  - 77
SN  - 0951-418X
AD  - Decosterd, L.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19950304468.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Horticultural Science
N2  - Bioassay-guided fractionation of the cytotoxic organic extracts of the wood of T. ahouia (collected from Honduras) led to the isolation of 3 cardenolide glycosides. These agents exhibited a distinctive pattern of differential cytotoxicity in the National Cancer Institute's human disease-oriented 60-cell line tumour screening panel.
KW  - cardenolides
KW  - cell lines
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - plant composition
KW  - plant extracts
KW  - wood
KW  - Honduras
KW  - Apocynaceae
KW  - man
KW  - Thevetia
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Apocynaceae
KW  - CACM
KW  - Central America
KW  - America
KW  - Developing Countries
KW  - Latin America
KW  - chemical constituents of plants
KW  - Thevetia ahouia
KW  - Plant Composition (FF040) 
KW  - Wood Properties, Damage and Preservation (KK510) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950304468&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Risk of HIV infection and AIDS in women and girls with coagulation disorders.
AU  - Goedert, I. J.
AU  - Garvey, L.
AU  - et al.
AU  - Hilgartner, M. W. (
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1994///
VL  - 8
IS  - 4
SP  - 564
EP  - 565
SN  - 0269-9370
AD  - Goedert, I. J.: AIDS and Cancer Section, Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006471.  Publication Type: Correspondence.  Language: English.  Registry Number: 113189-02-9. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - children
KW  - Coagulation
KW  - Factor VIII
KW  - Girls
KW  - haemophilia
KW  - HIV infections
KW  - Transfusion
KW  - Transmission
KW  - Women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - hemophilia
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006471&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques.
AU  - Clerici, M.
AU  - Clark, E. A.
AU  - Polacino, P.
AU  - Axberg, I.
AU  - Kuller, L. R.
AU  - Casey, N. I.
AU  - Morton, W. R.
AU  - Shearer, G. M.
AU  - Benveniste, R. E.
JO  - AIDS
JF  - AIDS
Y1  - 1994///
VL  - 8
IS  - 10
SP  - 1391
EP  - 1395
SN  - 0269-9370
AD  - Clerici, M.: Correspondence address: R.E. Benveniste, National Cancer Institute, B560, Frederick, MD 21702, USA.
N1  - Accession Number: 19952001384.  Publication Type: Journal Article.  Language: English. 
KW  - animal models
KW  - cell mediated immunity
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - infections
KW  - mucosa
KW  - T lymphocytes
KW  - Macaca
KW  - simian immunodeficiency virus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cellular immunity
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - mucous membrane
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001384&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Overcoming barriers to conducting research.
AU  - Ford, D. B.
AU  - Schiller, M. R.
JO  - Topics in Clinical Nutrition
JF  - Topics in Clinical Nutrition
Y1  - 1994///
VL  - 9
IS  - 3
SP  - 44
EP  - 50
SN  - 0883-5691
AD  - Ford, D. B.: Clinical Nutrition Services, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19951412905.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Human Nutrition
N2  - Integrating research and dietetic practice enhances professional roles of the dietitian. This integration is facilitated by strong organizational support and development of a dietetic-based research programme. Research is further strengthened by dietitians' ability to formulate clearly focused research questions and obtain resources, such as mentors and funding, to bring projects to completion. A case example is provided showing how dietitians were able to make significant advances in this area.
KW  - dietitians
KW  - funding
KW  - nutrition research
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412905&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phylogenetic study of ten new HTLV-I strains from the Americas.
AU  - Gessain, A.
AU  - Koralnik, I. J.
AU  - et al.
AU  - Fullen, J. (
AU  - Franchini, G.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 1
SP  - 103
EP  - 106
SN  - 0889-2229
AD  - Gessain, A.: (G. Franchini) Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, NIH, 9000 Rockville Pike, Rockville, MD 20892, USA.
N1  - Accession Number: 19942006657.  Publication Type: Journal Article.  Language: English.  Registry Number: 9007-49-2. 
KW  - DNA
KW  - DNA sequencing
KW  - Molecular biology
KW  - Phylogeny
KW  - Deltaretrovirus
KW  - HUMAN T-CELL LYMPHOTROPIC VIRUS
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - deoxyribonucleic acid
KW  - HTLV-BLV group
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006657&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pathogenicity, virulence and Entamoeba histolytica.
AU  - Clark, C. G.
AU  - Diamond, L. S.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1994///
VL  - 10
IS  - 2
SP  - 46
EP  - 47
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940805628.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - An attempt is made to resolve problems regarding the terms 'pathogenicity' and 'virulence' with respect to Entamoeba histolytica. It is concluded that E. histolytica is a pathogen of variable virulence capable of producing invasive disease and E. dispar appears to be an avirulent pathogen incapable of invading tissue. As far as is known E. coli and E. hartmanni are truly non-pathogenic.
KW  - human diseases
KW  - parasites
KW  - pathogenicity
KW  - terminology
KW  - virulence
KW  - Endamoebidae
KW  - Entamoeba
KW  - Entamoeba dispar
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Sarcomastigophora
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Endamoebidae
KW  - Entamoeba
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805628&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro susceptibility of Macaca nemestrina to human herpesvirus 6: a potential animal model of coinfection with primate immunodeficiency viruses.
AU  - Lusso, P.
AU  - Secchiero, P.
AU  - Crowley, R. W.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 2
SP  - 181
EP  - 187
SN  - 0889-2229
AD  - Lusso, P.: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006682.  Publication Type: Journal Article.  Language: English. 
KW  - Animal models
KW  - Pathogenesis
KW  - Herpesviridae
KW  - Macaca
KW  - SIMIAN IMMUNODEFICIENCY VIRUS
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Partial envelope sequences from some of the earliest isolates of HIV-1.
AU  - Reitz, M. S. Jr
AU  - Popovic, M.
AU  - Saxinger, W. C.
AU  - Hall, L.
AU  - Read-Connole, E.
AU  - Markham, P.
AU  - Gallo, R. C.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 5
SP  - 621
EP  - 623
SN  - 0889-2229
AD  - Reitz, M. S. Jr: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050559.  Publication Type: Journal Article.  Language: English. 
KW  - DNA sequencing
KW  - env gene
KW  - genomes
KW  - human immunodeficiency viruses
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050559&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A universally applicable diagnostic approach to filarial and other infections.
AU  - Nutman, T. B.
AU  - Zimmerman, P. A.
AU  - Kubofcik, J.
AU  - Kostyu, D. D.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1994///
VL  - 10
IS  - 6
SP  - 239
EP  - 243
AD  - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940805159.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Helminthology; Agricultural Biotechnology
N2  - This article discusses how the detection of parasite-specific PCR products using an ELISA-based assay can be used to distinguish between past and current infection and to assess efficacy of drug therapy (previously impossible using antibody-based assays, due to extensive cross-reactivity among filarial and other antigens). The filarial parasites considered are: Onchocerca volvulus, Brugia malayi, Loa loa and Wuchereria bancrofti.
KW  - biotechnology
KW  - diagnosis
KW  - DNA probes
KW  - ELISA
KW  - filariasis
KW  - helminths
KW  - immunodiagnosis
KW  - parasites
KW  - polymerase chain reaction
KW  - Brugia malayi
KW  - Loa loa
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Loa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - Wuchereria
KW  - African eyeworm
KW  - enzyme linked immunosorbent assay
KW  - nematodes
KW  - parasitic worms
KW  - PCR
KW  - Secernentea
KW  - serological diagnosis
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805159&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Organic thiophosphate WR-151327 suppresses expression of HIV in chronically infected cells.
AU  - Kalebic, T.
AU  - Schein, P. S.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 6
SP  - 727
EP  - 733
SN  - 0889-2229
AD  - Kalebic, T.: Laboratory of Molecular Genetics, Pediatric Branch, Building 10 Room 13C215, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051160.  Publication Type: Journal Article.  Language: English. 
KW  - antiviral agents
KW  - enzyme inhibitors
KW  - human immunodeficiency viruses
KW  - reverse transcriptase inhibitors
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - organic thiophosphate
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051160&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A C2 symmetry-based HIV protease inhibitor, A77003, irreversibly inhibits infectivity of HIV-1 in vitro.
AU  - Kageyama, S.
AU  - Hoekzema, D. T.
AU  - Murakawa, Y.
AU  - Kojima, E.
AU  - Shirasaka, T.
AU  - Kempf, D. J.
AU  - Norbeck, D. W.
AU  - Erickson, J.
AU  - Mitsuya, H.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 6
SP  - 735
EP  - 743
SN  - 0889-2229
AD  - Kageyama, S.: (H. Mitsuya) Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051161.  Publication Type: Journal Article.  Language: English. 
KW  - antiviral agents
KW  - Gag protein
KW  - human immunodeficiency viruses
KW  - proteinase inhibitors
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - processing granulocyte monocyte colony-stimulating factor
KW  - protease inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051161&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Activation of HIV type 1 long terminal repeat by ultraviolet light is serum and strain specific.
AU  - Carrier, F.
AU  - McCary, J. M.
AU  - Bae, I.
AU  - Yarosh, D. B.
AU  - Fornace, A. J. Jr
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 7
SP  - 767
EP  - 773
SN  - 0889-2229
AD  - Carrier, F.: Laboratory of Molecular Pharmacology, DTP, DCT, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952000324.  Publication Type: Journal Article.  Language: English. 
KW  - genomes
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - Tat protein
KW  - ultraviolet radiation
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - activation
KW  - human immunodeficiency virus
KW  - long terminal repeat
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000324&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mechanism of enzyme inhibition mediated by anti-reverse transcriptase antibodies from HIV type 1-infected individuals.
AU  - Devico, A. L.
AU  - Rahman, R.
AU  - Sarngadharan, M. G.
AU  - Di Marzo Veronese, F.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 8
SP  - 953
EP  - 960
SN  - 0889-2229
AD  - Devico, A. L.: Building 37, Room 6A17, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001302.  Publication Type: Journal Article.  Language: English. 
KW  - antibodies
KW  - antiviral agents
KW  - enzyme inhibitors
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - reverse transcriptase inhibitors
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001302&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tenth anniversary perspectives on AIDS: phylogenesis and genetic complexity of the nonhuman primary retroviridae.
AU  - Franchini, G.
AU  - Reitz, M. S. Jr
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 9
SP  - 1047
EP  - 1060
SN  - 0889-2229
AD  - Franchini, G.: Labour of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002647.  Publication Type: Journal Article.  Language: English.  Number of References: 222 ref.
KW  - evolution
KW  - molecular biology
KW  - natural history
KW  - phylogeny
KW  - man
KW  - retroviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002647&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Binding of glycoprotein 120 and peptides from the HIV-1 envelope by autoantibodies in mice with experimentally induced systemic lupus erythematosus and in patients with the disease.
AU  - Bermas, B. L.
AU  - Petri, M.
AU  - Berzofsky, J. A.
AU  - Waisman, A.
AU  - Shearer, G. M.
AU  - Mozes, E.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 9
SP  - 1071
EP  - 1077
SN  - 0889-2229
AD  - Bermas, B. L.: Experimental Immunology Branch, National Cancer Institute, NIH, Building 10, Room 4B-17, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002674.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref.
KW  - animal models
KW  - autoantibodies
KW  - autoimmunity
KW  - envelope protein gp120
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - systemic lupus erythematosus
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gp120
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002674&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Perinatal transmission of HIV type 1: associations with maternal anti-HIV serological reactivity.
AU  - Goedert, J. J.
AU  - Dublin, S.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 9
SP  - 1125
EP  - 1134
SN  - 0889-2229
AD  - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19952002683.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
KW  - antibodies
KW  - envelope proteins
KW  - epitopes
KW  - HIV infections
KW  - human diseases
KW  - maternal transmission
KW  - risk factors
KW  - antigenic determinants
KW  - human immunodeficiency virus infections
KW  - mother to child transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002683&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Viral variability and serum antibody response in a laboratory worker infected with HIV type 1 (HTLV type IIIB).
AU  - Reitz, M. S. Jr
AU  - Hall, L.
AU  - Robert-Guroff, M.
AU  - Lautenberger, J.
AU  - Hahn, B. M.
AU  - Shaw, G. M.
AU  - Kong, L. I.
AU  - Weiss, S. H.
AU  - Waters, D.
AU  - Gallo, R. C.
AU  - Blattner, W.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 9
SP  - 1143
EP  - 1155
SN  - 0889-2229
AD  - Reitz, M. S. Jr: Laboratory of Tumor Cell Biology, National Cancer Institute, Building 37, Room 6A09, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002687.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
KW  - Env gene
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - nucleotide sequences
KW  - occupational transmission
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - DNA sequences
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002687&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor α and interleukin 6 induction of virus.
AU  - Weissman, D.
AU  - Poli, G.
AU  - Fauci, A. S.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 10
SP  - 1199
EP  - 1206
SN  - 0889-2229
AD  - Weissman, D.: Laboratory of Immunoregulation, National Institutes of Health, Building 10, Room 6A02, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002065.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 308079-78-9. 
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - interleukins
KW  - macrophages
KW  - tumour necrosis factor
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002065&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mechanisms of HIV\SIV mucosal transmission.
AU  - Milman, G.
AU  - Sharma O.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 10
SP  - 1305
EP  - 1312
SN  - 0889-2229
AD  - Milman, G.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7620, USA.
N1  - Accession Number: 19962002076.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mucosa
KW  - transmission
KW  - man
KW  - simian immunodeficiency virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - mucous membrane
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002076&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Splicing variability in HIV type 1 revealed by quantitative RNA polymerase chain reaction.
AU  - Neumann, M.
AU  - Harrison, J.
AU  - Saltarelli, M.
AU  - Hadziyannis, E.
AU  - Erfle, V.
AU  - Felber, B. K.
AU  - Pavlakis, G. N.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 11
SP  - 1531
EP  - 1542
SN  - 0889-2229
AD  - Neumann, M.: National Cancer Institute, FCRDC, ABL-Basic Research Program, P.O. Box B/Building 539, Room 121 Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19962000896.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
KW  - gene splicing
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - polymerase chain reaction
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000896&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Subgroup G HIV type 1 isolates from Nigeria.
AU  - Abimiki, A. G.
AU  - Stern, T. L.
AU  - Zwandor, A.
AU  - Markham, P. D.
AU  - Calef, C.
AU  - Kyari, S.
AU  - Saxinger W. C.
AU  - Gallo, R. C.
AU  - Robert-Guroff, M.
AU  - Reitz, M. S.
JO  - Aids Research and Human Retroviruses
JF  - Aids Research and Human Retroviruses
Y1  - 1994///
VL  - 10
IS  - 11
SP  - 1581
EP  - 1583
SN  - 0889-2229
AD  - Abimiki, A. G.: Laboratory of Tumor Cell Biology, Bldg. 37, Rm. 6A09, National Cancer Institute, National Institutes of Health, 900 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962000902.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref.
KW  - genetic variation
KW  - HIV infections
KW  - Human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - subtypes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000902&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate: TBV25H expressed in yeast and purified using nickel-NTA agarose.
AU  - Kaslow, D. C.
AU  - Shiloach, J.
JO  - Bio/Technology
JF  - Bio/Technology
Y1  - 1994///
VL  - 12
IS  - 5
SP  - 494
EP  - 498
SN  - 0733-222X
AD  - Kaslow, D. C.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008350.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology
N2  - The authors have constructed a second generation malaria transmission-blocking vaccine candidate based on Pfs25, the predominate surface protein of Plasmodium falciparum zygotes, to overcome potential production problems with the original construct. Four modifications were made: (1) addition of the last cysteine residue of the fourth epidermal growth factor like-domain of Pfs25; (2) mutagenesis of asparagine-linked glycosylation sites with glutamine rather than alanine; (3) addition of a six histidine tag at the carboxyterminus for highly efficient purification of recombinant protein on nickel-NTA agarose; and (4) fermentation that combines continuous glucose fed-batch methodology with pH-controlled glucose addition and a terminal ethanol feed. The resulting product, TBV25H (Transmission-Blocking Vaccine based on Pfs25 with a Histidine tag), appears to be a more potent antigen and immunogen than the original construct, and the fermentation and post-fermentation processing methodology easily lend themselves to technology transfer to the ultimate users, newly industrialized countries.
KW  - candidate vaccines
KW  - human diseases
KW  - malaria
KW  - parasites
KW  - production
KW  - recombinant vaccines
KW  - surface antigens
KW  - transmission blocking immunity
KW  - vaccines
KW  - zygotes
KW  - man
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Plasmodium
KW  - Pfs25
KW  - transmission blocking vaccines
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008350&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site.
AU  - Sugimoto, Y.
AU  - Aksentijevich, I.
AU  - Gottesman, M. M.
AU  - Pastan, I.
JO  - Bio/Technology
JF  - Bio/Technology
Y1  - 1994///
VL  - 12
IS  - 7
SP  - 694
EP  - 698
SN  - 0733-222X
AD  - Sugimoto, Y.: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940106314.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 82410-32-0, 9002-06-6, 57-22-7.  Subject Subsets: Agricultural Biotechnology
N2  - A new retroviral vector system (pSXLC/pHa) was constructed which utilizes a putative ribosome internal entry site (IRES) from encephalomyocarditis virus, downstream of a multicloning site, to coexpress drug-selectable markers with a non-selectable cDNA in a eukaryote expression vector. The positive drug-selectable marker MDR1 (encoding the plasma membrane P-glycoprotein) and the herpes simplex virus thymidine kinase positive-negative marker (which can act both as a selectable marker in thymidine kinase-deficient cells and as a suicide gene in vivo and vitro) were cloned in the pSXLC/pHa system and, under translational control of IRES, expressed in transfected cultured mammalian cells. The inserts of the 2 pSXLC plasmids were designed for easy transfer to the pHA retroviral vector, which has a strong promoter from Harvey murine sarcoma virus. The retroviral vector carrying IRES-MDR1 conferred resistance to vincristine and adriamycin. The IRES-thymidine kinase vector conferred resistance to HAT medium in thymidine kinase-deficient cells, and the transfectants showed hypersensitivity to ganciclovir. This system is potentially useful in gene therapy strategies.
KW  - animal viruses
KW  - antineoplastic agents
KW  - biotechnology
KW  - cell lines
KW  - drug resistance
KW  - ganciclovir
KW  - gene expression
KW  - gene therapy
KW  - gene transfer
KW  - marker genes
KW  - plasmids
KW  - retroviral vectors
KW  - thymidine kinase
KW  - vectors
KW  - vincristine
KW  - animals
KW  - viruses
KW  - eukaryotes
KW  - cloning
KW  - cytotoxic agents
KW  - selectable markers
KW  - viruses of animals
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Animal Tissue and Cell Culture (LL700) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940106314&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adaptive control with feedback of suramin using intermittent infusions.
AU  - Figg, W. D.
AU  - Stevens, J. A.
AU  - Cooper, M. R.
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
Y1  - 1994///
VL  - 12
IS  - 7
SP  - 1523
EP  - 1524
SN  - 0732-183X
AD  - Figg, W. D.: National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19940806619.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref. Registry Number: 145-63-1.  Subject Subsets: Protozoology
KW  - antiprotozoal agents
KW  - parasites
KW  - pharmacokinetics
KW  - suramin
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940806619&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunogenicity of recombinant influenza virus haemagglutinin carrying peptides from the envelope protein of human immunodeficiency virus type 1.
AU  - Kalyan, N. K.
AU  - Lee, S. G.
AU  - et al.
AU  - Wilhelm, J. (
JO  - Vaccine
JF  - Vaccine
Y1  - 1994///
VL  - 12
IS  - 8
SP  - 753
EP  - 760
SN  - 0264-410X
AD  - Kalyan, N. K.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006317.  Publication Type: Journal Article.  Language: English. 
KW  - chimaeras
KW  - haemagglutinins
KW  - immune response
KW  - Immunization
KW  - influenza viruses
KW  - Animals
KW  - Human immunodeficiency virus 1
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Orthomyxoviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - chimeras
KW  - hemagglutinins
KW  - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - Influenzavirus
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006317&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Crossover of placebo patients to intravenous immunoglobulin confirms efficacy for prophylaxis of bacterial infections and reduction of hospitalizations in human immunodeficiency virus-infected children.
AU  - Mofenson, L. M.
AU  - Moye, J. Jr
AU  - et al.
AU  - Korelitz, J. (
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1994///
VL  - 13
IS  - 6
SP  - 477
EP  - 484
SN  - 0891-3668
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA.
N1  - Accession Number: 19942007062.  Publication Type: Journal Article.  Language: English.  Registry Number: 308067-57-4, 723-46-6, 738-70-5. 
KW  - Bacterial diseases
KW  - Children
KW  - clinical trials
KW  - drug combinations
KW  - HIV infections
KW  - immunoglobulins
KW  - intravenous injection
KW  - sulfamethoxazole
KW  - Treatment
KW  - trimethoprim
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - gamma-globulins
KW  - human immunodeficiency virus infections
KW  - immune globulins
KW  - sulfamethoxazole trimethoprim
KW  - sulphamethoxazole
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007062&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A blueprint for care, treatment, and prevention of HIV/AIDS in children.
AU  - Wilfert, C. M.
AU  - Pizzo, P. A.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1994///
VL  - 13
IS  - 10
SP  - 920
EP  - 923
SN  - 0891-3668
AD  - Wilfert, C. M.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002321.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref.
KW  - children
KW  - community care
KW  - HIV infections
KW  - human diseases
KW  - infants
KW  - management
KW  - prevention
KW  - treatment
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002321&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells.
AU  - Benkirane, M.
AU  - Jeang, K. T.
AU  - Devaux, C.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1994///
VL  - 13
IS  - 23
SP  - 5559
EP  - 5569
SN  - 0261-4189
AD  - Benkirane, M.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952004495.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
KW  - cd4 antigens
KW  - cells
KW  - cytoplasm
KW  - HIV infections
KW  - immunology
KW  - infection
KW  - T lymphocytes
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - human immunodeficiency virus infections
KW  - surface receptor
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004495&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.
AU  - Chang, Y. C.
AU  - Kwon-Chung, K. J.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1994///
VL  - 14
IS  - 7
SP  - 4912
EP  - 4919
SN  - 0270-7306
AD  - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201775.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The molecular basis of capsule synthesis in C. neoformans was studied using a capsule-deficient phenotype of a mutant strain which was complemented by transformation. A plasmid rescued from the resulting Cap+ transformant complemented a cap59 mutation which was mapped previously by classical recombination analysis. Gene deletion by homologous integration resulted in an acapsular phenotype, indicating the identification of the CAP59 gene. The CAP59 gene was assigned to chromosome I by Southern blot analysis of contour-clamped homogeneous electric field gel electrophoresis-resolved chromosomes of C. neoformans var. neoformans. Sequence comparison of genomic and cDNA clones indicated the presence of 6 introns. CAP59 encoded a 1.9 kb transcript and a deduced protein of 458 amino acids. Analysis of the nucleotide sequence revealed little similarity to existing sequences in the data bank. When the capsule-deficient phenotype was complemented, the originally avirulent C. neoformans strain became virulent in mice and the acapsular strain created by gene deletion of CAP59 lost its virulence. It is concluded that these results indicate the molecular basis for capsule-related virulence and that the CAP59 gene is required for capsule formation.
KW  - complementation
KW  - experimental infections
KW  - genetics
KW  - infections
KW  - mutants
KW  - pathogenicity
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - capsule
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201775&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunoglobulin idiotype antigen vaccines for the treatment of lymphomas.
AU  - Kwak, L. W.
JO  - Clinical Immunology Newsletter
JF  - Clinical Immunology Newsletter
Y1  - 1994///
VL  - 14
IS  - 9
SP  - 121
EP  - 124
SN  - 0197-1859
AD  - Kwak, L. W.: Biological Response Modifiers Program, National Cancer Institute, Frederick, Maryland, USA.
N1  - Accession Number: 19962004023.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 308067-57-4. 
N2  - The author reviews the use of idiotypic determinants of the surface immunoglobulin of a B cell lymphoma as a tumour-antigen for vaccine development.
KW  - antigens
KW  - immunization
KW  - immunoglobulins
KW  - lymphoma
KW  - neoplasms
KW  - reviews
KW  - vaccine development
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - cancers
KW  - gamma-globulins
KW  - immune globulins
KW  - immune sensitization
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hepatitis-B markers in sera of Egyptian hepatoma patients.
AU  - El-Aaser, A. A.
AU  - Zakhary, N. I.
AU  - Sharawi, S. M.
AU  - El-Demerdash, S.
AU  - Hamza, M. R.
AU  - Kamel, R.
AU  - Michael, M. S.
JO  - Qatar University Science Journal
JF  - Qatar University Science Journal
Y1  - 1994///
VL  - 14
IS  - SPEC/ISSUE
SP  - 21
EP  - 25
AD  - El-Aaser, A. A.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 19982000900.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref.
N2  - To investigate the possible role of hepatitis B virus (HBV) infection in the aetiology of hepatoma among Egyptians, 52 hepatoma patients (aged 38-72 years) from Egypt were studied. The 3 hepatitis B markers, hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb) and hepatitis B core antibody (HBcAb), were estimated in the patients' sera and compared with healthy controls. Results revealed a striking correlation between clinical or subclinical history of HBV infection or even carrier rate, and hepatoma, since 94.2% of the hepatoma patients were positive for one or more of the hepatitis markers studied. The higher prevalence of HBV infection was observed among HCC patients (97%) than among other types of hepatoma patients (66%; P=0.03). HBsAb and HBcAb were positive among 80.8% (P&lt;0.01) and 84.6% (P&lt;0.01) of hepatoma patients; respectively, whereas they were completely absent in sera of controls. However, HBsAg was positive among 13.5% only of the hepatoma patients, revealing no significant changes when compared with controls (P=0.133). No significant correlation was observed between HBsAb positive patients and those who were positive for HBcAb (P=0.35).
KW  - aetiology
KW  - antibodies
KW  - antigens
KW  - carcinoma
KW  - clinical aspects
KW  - disease markers
KW  - hepatitis
KW  - hepatitis B
KW  - hepatoma
KW  - histopathology
KW  - human diseases
KW  - infection
KW  - neoplasms
KW  - patients
KW  - viral diseases
KW  - Egypt
KW  - hepatitis B virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - antigenicity
KW  - cancers
KW  - causal agents
KW  - clinical picture
KW  - etiology
KW  - immunogens
KW  - Misr
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adduction of the heterocyclic amine food mutagens IQ and PhIP to mitochondrial and nuclear DNA in the liver of Fischer-344 rats.
AU  - Davis, C. D.
AU  - Schut, H. A. J.
AU  - Snyderwine, E. G.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1994///
VL  - 15
IS  - 4
SP  - 641
EP  - 645
SN  - 0143-3334
AD  - Davis, C. D.: Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951413002.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 9007-49-2.  Subject Subsets: Human Nutrition
N2  - The heterocyclic amines 2-amino-3-methylimidazo(4,5-f)quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) are carcinogens that form DNA adducts. The 32P-postlabelling method was used to measure the levels of IQ and PhIP adducts in hepatic nuclear and mitochondrial DNA of Fischer-344 rats given a single dose (100 mg/kg, p.o.) or 10 doses of either carcinogen. After a single dose of IQ, adduct levels were &gt;2-fold higher in hepatic nuclear than in mitochondrial DNA; however, after repeated IQ exposure, the levels of adducts in nuclear and mitochondrial DNA were not significantly different. In contrast, after a single dose of PhIP, there were no significant differences in adduct levels in nuclear and mitochondrial DNA; however, after multiple doses of PhIP, adduct levels were significantly higher in mitochondrial DNA than in nuclear DNA. The percentages of individual IQ or PhIP adducts were different between nuclear DNA and mitochondrial DNA, particularly after 10 doses. With IQ, the C8-guanine adduct accounted for 72% of the total IQ adduct levels in nuclear DNA but only 40% of total adduct levels in mitochondrial DNA. After 10 doses of PhIP, the C8-guanine adduct accounted for 48% and 15% of total adduct levels in nuclear DNA and mitochondrial DNA, respectively. In addition, the percentage of an uncharacterized PhIP adduct was 14% in nuclear DNA but &lt;1% in mitochondrial DNA. The percentages of individual adducts were about the same 3, 24, 120 and 240 h after a single dose of either compound, though total IQ and PhIP adduct levels appeared to decline over time in both organelles.
KW  - carcinogenesis
KW  - DNA
KW  - heterocyclic nitrogen compounds
KW  - liver
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
AU  - Devereux, T. R.
AU  - White, C. M.
AU  - Sills, R. C.
AU  - Bucher, J. R.
AU  - Maronpot, R. R.
AU  - Anderson, M. W.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1994///
VL  - 15
IS  - 5
SP  - 1083
EP  - 1087
SN  - 0143-3334
AD  - Devereux, T. R.: Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19951412036.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
KW  - adenoma
KW  - antidepressants
KW  - benzodiazepines
KW  - carcinoma
KW  - drugs
KW  - intake
KW  - liver
KW  - neoplasms
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - medicines
KW  - pharmaceuticals
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High dietary retinoic acid prevents malignant conversion of skin papillomas induced by a two-stage carcinogenesis protocol in female SENCAR mice.
AU  - Chen, L. C.
AU  - Sly, L.
AU  - Luca, L. M. de
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1994///
VL  - 15
IS  - 10
SP  - 2383
EP  - 2386
SN  - 0143-3334
AD  - Chen, L. C.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951411159.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - High dietary retinoic acid (RA; 30 µg/g diet) inhibits carcinoma formation in a 2-stage skin carcinogenesis protocol, using 7,12-dimethylbenz[a]anthracene (DMBA) as the initiator and 12-O-tetradecanoyl phorbol-13-acetate (TPA) as the tumour-promoter in female SENCAR mice. The study examined whether switching the diets from high to control levels of RA and vice versa would influence carcinoma formation. Mice at 3 weeks of age were initiated with DMBA (20 µg) once, followed by 20 weekly applications of TPA (2 µg). At 3 weeks of age mice were weaned onto a diet containing RA 3 (control) or 30 (high) µg/g diet. Half of the mice from either group were switched to the other diet at 20 weeks of age, when papilloma formation was at its peak. These 4 groups were designated RA 3 µg, RA 30 µg, RA 3/30 µg and RA 30/3 µg groups. As previously found, papilloma formation (including incidence and yield) was not significantly affected by dietary treatment. However, high dietary RA inhibited carcinoma formation; specifically cumulative carcinoma incidence (18.5-23.1 versus 50%) and yield (0.19-0.23 versus 0.68) were significantly lower in the high dietary RA treatment groups than the RA 3 µg control group, as was the carcinoma conversion efficiency (2.1-3.8 versus 9.4%). The beneficial effect on carcinoma formation was still evident when excess RA was given late during the carcinogenesis process (i.e. the RA 3/30 µg group). Moreover, a residual effect of excess RA was also seen after the dietary RA was switched to the control level at 20 weeks of age, when papilloma yield was highest (i.e. the RA 30/3 µg group). It is therefore concluded that the chemopreventive effect of high dietary RA on skin carcinogenesis induced by a 2-stage carcinogenesis protocol with DMBA and TPA resides mainly at the step of conversion from benign papillomas to malignant carcinomas.
KW  - carcinogenesis
KW  - intake
KW  - papilloma
KW  - retinoic acid
KW  - skin
KW  - vitamins
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dermis
KW  - papillomas
KW  - tretinoin
KW  - vitamin A acid
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411159&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Techniques and diagnostic applications of in vitro nucleic-acid amplification.
AU  - Cartwright, C. P.
JO  - Clinical Microbiology Newsletter
JF  - Clinical Microbiology Newsletter
Y1  - 1994///
VL  - 16
IS  - 5
SP  - 33
EP  - 37
SN  - 0196-4399
AD  - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942026379.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Public Health
KW  - amplification
KW  - diagnosis
KW  - Infectious diseases
KW  - nucleic acids
KW  - reviews
KW  - communicable diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026379&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical studies on the effect of garlic on liver and intestine of schistosomal mice.
AU  - Zakhary, N. I.
JO  - Egyptian Journal of Bilharziasis
JF  - Egyptian Journal of Bilharziasis
Y1  - 1994///
VL  - 16
IS  - 1/2
SP  - 107
EP  - 127
AD  - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 19960804999.  Publication Type: Journal Article.  Language: English.  Language of Summary: Arabic.  Number of References: 44 ref. Registry Number: 9001-78-9, 57-88-5, 9007-49-2, 9005-79-2.  Subject Subsets: Botanical Pesticides; Horticultural Science; Helminthology
N2  - The protective effect of garlic (Allium sativum) against schistosome infection in mice was investigated. Five groups of 20 mice were treated as follows: uninfected untreated controls; uninfected mice fed on diet containing 20% garlic for 3 weeks; mice infected with 50 cercariae of Schistosoma mansoni and fed on standard diet; S. mansoni-infected mice fed with diet containing 20% garlic for 3 weeks, beginning 1 week before infection; and S. mansoni-infected mice fed with diet containing 20% garlic for 3 weeks, beginning 7 weeks after infection. Growth rate was measured weekly and liver and intestinal homogenates were analysed from 10 mice in each group sacrificed 10 weeks after the start of the experiment. Infected mice showed retarded growth rate and reduced levels of cholesterol, glycogen and enzyme activity in their livers although alkaline phosphatase activity and protein and DNA contents were significantly increased. Enzyme activity was also reduced in the intestine and the DNA content was increased. Infected mice maintained on diet with 20% garlic from 1 week prior to infection showed no significant changes in these parameters, which were similar to those in uninfected untreated controls. There was little difference between these parameters in infected mice fed standard diet and infected mice fed 20% garlic from 7 weeks postinfection, suggesting that garlic is protective against the effects of cercarial infection but not against adult worms. Uninfected mice fed garlic showed no changes when compared with uninfected controls, showing that garlic has no harmful effects on the parameters studied.
KW  - alkaline phosphatase
KW  - anthelmintics
KW  - cercariae
KW  - cholesterol
KW  - DNA
KW  - drug therapy
KW  - enzyme activity
KW  - experimental infections
KW  - extracts
KW  - garlic
KW  - glycogen
KW  - growth
KW  - helminths
KW  - intestines
KW  - laboratory animals
KW  - liver
KW  - medicinal plants
KW  - parasites
KW  - plant extracts
KW  - proteins
KW  - Allium sativum
KW  - mice
KW  - Schistosoma mansoni
KW  - Allium
KW  - Alliaceae
KW  - Liliaceae
KW  - Liliales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - alkaline phosphomonoesterase
KW  - chemotherapy
KW  - deoxyribonucleic acid
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - parasitic worms
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biological Resources (Plant) (PP720) 
KW  - Plant Science (General) (FF000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Separation of taxol and related compounds by micellar electrokinetic chromatography.
AU  - Chan, K. C.
AU  - Muschik, G. M.
AU  - Issaq, H. J.
AU  - Snader, K. M.
JO  - HRC, Journal of High Resolution Chromatography
JF  - HRC, Journal of High Resolution Chromatography
Y1  - 1994///
VL  - 17
IS  - 1
SP  - 51
EP  - 52
SN  - 0935-6304
AD  - Chan, K. C.: National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA.
N1  - Accession Number: 19950308100.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Taxol, isolated from the bark and needles of Taxus brevifolia, exhibits antineoplastic and antileukaemic properties. Micellar electrokinetic chromatography was used to separate taxol, cephalomannine and baccatin III, and their deacetylated derivatives, in &lt;15 min, using ng amounts of sample and a few µlitres of solvent per run.
KW  - analytical methods
KW  - chromatography
KW  - diterpenoid alkaloids
KW  - diterpenoids
KW  - extraction
KW  - medicinal plants
KW  - medicinal properties
KW  - plant composition
KW  - Taxaceae
KW  - Taxus brevifolia
KW  - Taxopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Taxus
KW  - Taxaceae
KW  - analytical techniques
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The sagittal waist diameter and mortality in men: the Baltimore Longitudinal Study on Aging.
AU  - Seidell, J. C.
AU  - Andres, R.
AU  - Sorkin, J. D.
AU  - Muller, D. C.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1994///
VL  - 18
IS  - 1
SP  - 61
EP  - 67
SN  - 0307-0565
AD  - Seidell, J. C.: Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
N1  - Accession Number: 19941406075.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - The relation between abdominal sagittal diameter (waist depth) and subsequent mortality was evaluated in 981 men (51.2±16.6 years old) from the Baltimore Longitudinal Study on Aging (a prospective study at the National Institute on Aging in Baltimore, USA). The main outcome measures were total and cause-specific mortality occurring during 17 529 person-years. Men were divided by age (&lt;55 years old or &gt;55 years old) at the start of follow-up. All-cause and coronary heart disease mortality rates (adjusted for age, height and body mass index) increased with increasing sagittal diameter in the younger group but not in the older group. No significant relation was observed between the sagittal diameter and cancer mortality. Body mass index, skinfolds and waist/hip ratio were not significantly related to any of the end points studied. The increased risk of mortality with increasing sagittal diameter was somewhat stronger when the first 10 years of follow-up were excluded and was more pronounced at lower levels of risk factors such as serum cholesterol, serum triacylglycerols, blood sugar and diastolic blood pressure and in never plus ex-smokers compared with smokers. It is indicated that the abdominal sagittal diameter is a strong predictor of mortality in younger adult men independently of age, height, body mass index and conventional risk factors for mortality such as smoking, serum lipids and blood pressure. Regional adiposity may be a less strong risk factor for mortality in older men.
KW  - age
KW  - body composition
KW  - body fat
KW  - body measurements
KW  - carcinoma
KW  - cardiovascular diseases
KW  - distribution
KW  - men
KW  - mortality
KW  - obesity
KW  - risk
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - death rate
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Temporal association between implementation of universal precautions and a sustained, progressive decrease in percutaneous exposures to blood.
AU  - Beekmann, S. E.
AU  - Vlahov, D.
AU  - Koziol, D. E.
AU  - McShalley, E. D.
AU  - Schmitt, J. M.
AU  - Henderson, D. K.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1994///
VL  - 18
IS  - 4
SP  - 562
EP  - 569
SN  - 1058-4838
AD  - Beekmann, S. E.: (D.K. Henderson) Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C146, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006228.  Publication Type: Journal Article.  Language: English. 
KW  - Health care workers
KW  - HIV infections
KW  - needlestick injuries
KW  - Prevention
KW  - Transmission
KW  - human immunodeficiency virus infections
KW  - Universal precautions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body mass index and mortality in Seventh-day Adventist men. A critique and re-analysis.
AU  - Sorkin, J. D.
AU  - Muller, D.
AU  - Andres, R.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1994///
VL  - 18
IS  - 11
SP  - 752
EP  - 754
SN  - 0307-0565
AD  - Sorkin, J. D.: National Institute on Aging, Epidemiology, Demography, and Biometry Program, Gateway Building, Suite 3C309, 7201 Wisconsin Avenue, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951401035.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Human Nutrition
N2  - The study examined whether the relation between weight-adjusted-for-height (expressed as body mass index or BMI) using the BMI-at-entry and age-at-entry as opposed to BMI at entry and age-at-event (i.e., death, loss to follow-up, or end of the study) would alter the results previously reported from a population of Seventh-day Adventist American men. The subjects were 8828 non-smoking, non-drinking Seventh-day Adventist men, 30-89 years and older on entry, mean follow-up 15 years (maximum 26 years). The BMI and age reported by subjects when they were enrolled into the study were used to calculate the relation between BMI and mortality. Mortality rates in each of 5 BMI quintiles were computed by dividing the number of deaths in each quintile by the number of person-years of follow-up in the quintile. Rate ratios were computed by dividing each mortality rate by the rate in the reference quintile. The mortality rate ratios were then adjusted for the age difference between each quintile and the reference quintile. Calculations based upon age-at-enrollment rather than "age-at-event" demonstrate no increase in mortality until a BMI of 27.5 kg/m² or greater is reached rather than a progressive increase in mortality with increasing BMI.
KW  - body measurements
KW  - body weight
KW  - men
KW  - mortality
KW  - religion
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - death rate
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Glycemic response to stress is altered in euglycemic Pima Indians.
AU  - Esposito-Del Puente, A.
AU  - Lillioja, S.
AU  - Bogardus, C.
AU  - McCubbin, J. A.
AU  - Feinglos, M. N.
AU  - Kuhn, C. M.
AU  - Surwit, R. S.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1994///
VL  - 18
IS  - 11
SP  - 766
EP  - 770
SN  - 0307-0565
AD  - Esposito-Del Puente, A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
N1  - Accession Number: 19951401038.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - The effects of a computer-driven mental arithmetic task on blood glucose were studied in a group of 4 male and 4 female euglycaemic Caucasians and a group of 7 male and 6 female euglycaemic Pima Indians. Approximately 60% of euglycaemic Pima Indian Native Americans eventually develop type 2 diabetes, while only 5% of Caucasians develop the disease. All subjects had normal glucose tolerance. Subjects were given a standard breakfast; 2 h later, they were given a computerized mental arithmetic stress test for 10 min. Before, during and after the test, several variables were analysed, including serum concentrations of glucose, insulin, glucagon and plasma cortisol and catecholamines. Heart rate, systolic and diastolic blood pressure and all the stress hormones increased during stress and decreased during recovery in all subjects. Blood glucose consistently declined 1 h after the meal in all subjects. However, while it continued to decline following stress in 7 of 8 Caucasian subjects, it consistently increased during and following stress in 10 of 13 Pima Indians. Fasting serum glucose in Pima Indians and Caucasians was respectively 5.07 + 0.08 and 5.04 + 0.09 mM. 2-h post-prandial values were 5.63 + 0.22 and 5.48 + 0.19 mM, respectively, whereas post-stress values were 6.15 + 0.19 for Pima Indians and 5.22 + 0.20 mM for Caucasians. Both serum glucose means following stress (t = 3.1, P&lt;0.005) and the direction of change in serum glucose in response to mental arithmetic (χ² = 8.2, P&lt;0.01) clearly differentiated Pimas from Caucasians. The data suggest that abnormal glycaemic responsiveness to stress, even in the absence of impaired glucose tolerance, may be present in subjects at high risk of developing diabetes and may therefore be related in some way to the chain of events leading to the development of the disease.
KW  - blood sugar
KW  - diabetes
KW  - ethnic groups
KW  - mental stress
KW  - stress
KW  - sympathetic nervous system
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood glucose
KW  - glucose in blood
KW  - psychological stress
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401038&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiretroviral therapy for infection due to human immunodeficiency virus in children.
AU  - Pizzo, P. A.
AU  - Wilfert, C.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1994///
VL  - 19
IS  - 1
SP  - 177
EP  - 196
SN  - 1058-4838
AD  - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050461.  Publication Type: Journal Article.  Language: English.  Number of References: 178 ref.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - children
KW  - HIV infections
KW  - treatment
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050461&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasive zygomycosis due to Conidiobolus incongruus.
AU  - Walsh, T. J.
AU  - Renshaw, G.
AU  - Andrews, J.
AU  - Kwon-Chung, J.
AU  - Cunnion, R. C.
AU  - Pass, H. I.
AU  - Taubenberger, J.
AU  - Wilson, W.
AU  - Pizzo, P. A.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1994///
VL  - 19
IS  - 3
SP  - 423
EP  - 430
SN  - 1058-4838
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951202970.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in 32-yr-old granulocytopenic woman from Maryland, USA, who developed rapidly progressive pneumonia and fatal pericardial zygomycosis due to C. incongruus. The microbiological characteristics, histological features and antifungal susceptibility of the isolate are described. Previously reported cases of deeply invasive zygomycosis due to Conidiobolus spp. are also reviewed. It is concluded that in immunocompromised patients, C. incongruus is an uncommon but highly invasive fungal pathogen that may be resistant to amphotericin B and can be distinguished from other Zygomycetes fungi by characteristic mycological features.
KW  - case reports
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunosuppression
KW  - infections
KW  - opportunistic infections
KW  - predisposition
KW  - zygomycosis
KW  - Maryland
KW  - USA
KW  - Ancylistaceae
KW  - Conidiobolus
KW  - Entomophthoraceae
KW  - man
KW  - Ancylistaceae
KW  - Entomophthorales
KW  - Entomophthoromycotina
KW  - Zygomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Conidiobolus
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Conidiobolus incongruus
KW  - fungus
KW  - phycomycosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202970&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phylogenetic spectrum of fungi that are pathogenic to humans.
AU  - Kwon-Chung, K. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1994///
VL  - 19
IS  - Suppl. 1
SP  - S1
EP  - S7
SN  - 1058-4838
AD  - Kwon-Chung, K. J.: Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951201521.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Recent phylogenetic studies based on ribosomal RNA sequences of pathogenic fungi are discussed in relation to the classification of Pythium insidiosum, Prototheca and Pneumocystis carinii.
KW  - human diseases
KW  - infections
KW  - mycoses
KW  - phylogeny
KW  - pneumocystosis
KW  - protothecosis
KW  - taxonomy
KW  - Chlorellaceae
KW  - Chlorellales
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Prototheca
KW  - Pythiaceae
KW  - Pythium insidiosum
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Chlorellaceae
KW  - Chlorellales
KW  - Chlorophyta
KW  - algae
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - Pythium
KW  - Pythiaceae
KW  - Pythiales
KW  - Oomycetes
KW  - Oomycota
KW  - Mastigomycotina
KW  - Focus on fungal infections 3
KW  - fungus
KW  - Peronosporomycetes
KW  - pythiosis
KW  - Straminipila
KW  - systematics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Administration of the antimycotic agents fluconazole and itraconazole to leukaemia patients: a comparative pharmacokinetic study.
AU  - Lazo de la Vega, S.
AU  - Volkow, P.
AU  - Yeates, R. A.
AU  - Pfaff, G.
JO  - Drugs under Experimental and Clinical Research
JF  - Drugs under Experimental and Clinical Research
Y1  - 1994///
VL  - 20
IS  - 2
SP  - 69
EP  - 75
SN  - 0378-6501
AD  - Lazo de la Vega, S.: R. A. Yeates, Department of Infectious Diseases, National Cancer Institute, Tlalpan 14000, Mexico City, Mexico.
N1  - Accession Number: 19951200017.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 84625-61-6, 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - A randomized parallel design comparative study of serum concn of fluconazole and itraconazole after oral administration of 100 mg to 20 patients with leukaemia (10 in each group) was conducted. The drugs were administered with a standard breakfast immediately before the start of chemotherapy (day 1) and on days 8 and 15. There were no significant differences (P&gt;0.05) in the pharmacokinetic parameters of fluconazole (AUC, Cmax, Tmax) during the 3 d of the trial. It is concluded that there is no clinically important pharmacokinetic interaction between fluconazole and the chemotherapeutic agents given to this group of patients. A pharmacokinetic interaction between fluconazole and the fever suffered by some of the patients was unlikely. No significant differences (P&gt;0.05) in the pharmacokinetic parameters of itraconazole (AUC, Cmax, Tmax) were found during the 3 d, although the statistical power of the data was low. The significantly greater variability of all pharmacokinetic parameters for itraconazole than for fluconazole and the sharp increases and decreases in AUC during the course of the trial found for some patients in the itraconazole group indicated the need for caution in this group of patients.
KW  - antifungal agents
KW  - drug therapy
KW  - fluconazole
KW  - immunocompromised hosts
KW  - itraconazole
KW  - leukaemia
KW  - pharmacokinetics
KW  - blood cancer
KW  - chemotherapy
KW  - fungistats
KW  - leucaemia
KW  - leukemia
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of Vicia faba and bran feeding on nitrosamine carcinogenesis and formation.
AU  - Zakhary, N. I.
AU  - El-Aaser, A. A.
AU  - Abdelwahab, A. A.
AU  - Fathey, S. A.
AU  - Aboul-Ela, F.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 21
IS  - 1
SP  - 59
EP  - 69
SN  - 0163-5581
AD  - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 20001413430.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 9001-78-9.  Subject Subsets: Human Nutrition
N2  - The goal of this work was to study the effect of the most common Egyptian food items, Vicia faba beans (VF) and bran, on the carcinogenicity of dibutylnitrosamine (DBN) precursors (dibutylamine and nitrite). Mice receiving DBN precursors showed a delayed gain in body weight as well as decreased protein level and 5-nucleotidase activity. Acid ribonuclease, alkaline phosphatase, and DNA level and rate of synthesis were significantly increased compared with corresponding controls. Hepatomas and bladder papillomas developed in 60% and 40% of mice, respectively, after nine months of treatment. On the other hand, administration of VF or bran, in addition to DBN precursors, lessened the damage caused by DBN precursors alone, except DNA level and rate of synthesis were elevated. Alkaline phosphatase was also elevated when bran was administered with DBN precursors. However, these elevations were still less than corresponding elevations in mice receiving DBN precursors alone. The incidence of hepatoma was also reduced to only 20% for both groups. Meanwhile, incidence of bladder papillomas was only 20% in mice receiving VF in addition to DBN precursors, and bladder papillomas were completely absent in mice receiving bran in addition to DBN precursors. In vitro studies were also performed to clarify the effect of VF or bran on diphenylnitrosamine (DPhNA) and its formation from its precursors (diphenylamine and nitrite). The study revealed that VF and bran have the ability to eliminate nitrite and DPhNA from the reaction media and to reduce the rate of formation of DPhNA from its precursors. This reaction depends on the concentration and form of VF or bran and the duration of the reaction. Thus it is concluded that some naturally occurring food items, such as VF and bran, could protect humans against the hazardous effect of nitrosamines and their precursors.
KW  - alkaline phosphatase
KW  - animal models
KW  - beans
KW  - bladder
KW  - body weight
KW  - carcinogenesis
KW  - carcinogens
KW  - faba beans
KW  - feeding
KW  - in vitro
KW  - nitrosamines
KW  - precursors
KW  - synthesis
KW  - man
KW  - mice
KW  - Vicia
KW  - Vicia faba
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Vicia
KW  - alkaline phosphomonoesterase
KW  - broad beans
KW  - fava beans
KW  - field beans
KW  - horse beans
KW  - tic beans
KW  - urinary bladder
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413430&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinol and β-carotene concentrations in skin, papillomas and carcinomas, liver, and serum of mice fed retinoic acid or β-carotene to suppress skin tumor formation.
AU  - Jones, C. S.
AU  - Sly, L.
AU  - Chen LiChuan
AU  - Ben, T.
AU  - Brugh-Collins, M.
AU  - Lichti, U.
AU  - Luca, L. M. de
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 21
IS  - 1
SP  - 83
EP  - 93
SN  - 0163-5581
AD  - Jones, C. S.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001413432.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 7235-40-7, 302-79-4, 68-26-8.  Subject Subsets: Human Nutrition
N2  - Using 7,12-dimethylbenz[a]anthracene as the initiator and 12-O-tetradecanoyl-13-acetate as the tumor promoter on the dorsal skin of Sencar mice, we previously showed that pharmacological dietary all-trans-retinoic acid and β-carotene inhibit the conversion of papillomas to carcinomas in a two-stage system of chemical carcinogenesis. The purpose of this study was to determine the influence of dietary retinoic acid and β-carotene on retinoid and β-carotene concentrations in skin and other tissues. We were unable to measure tissue retinoic acid because of the relatively limited amount of tissue available for analysis and the fast rate of metabolism. Different dietary levels of retinoic acid or β-carotene did not influence total retinol of skin, papilloma, and carcinoma tissues, which all showed a concentration of approximately 1±0.5 µg/g wet wt. Equally refractory to dietary retinoic acid or β-carotene was serum retinol concentration. In contrast, dietary retinoic acid protected loss of liver retinol and retinyl palmitate, and β-carotene caused an increase in β-carotene and retinyl palmitate in liver but did not affect serum and liver retinol. We further investigated metabolic and functional aspects of retinoic acid in cultured mouse epidermal keratinocytes (LC-8 cells) and found that these cells actively metabolized [10,11-14C]retinoic acid to polar compounds. Isomers of retinoic acid were a minor product in the presence of cells and the major product when incubated in serum-containing medium in the absence of cells. From the functional point of view, exposure of LC-8 cells to 3×10-6 M all-trans-retinoic acid (RA) caused a 75-fold induction in tissue transglutaminase and an approximately 9-fold induction in 10-6 M RA at three days of culture. We conclude that retinoic acid spares endogenous retinol and that β-carotene greatly enhances liver retinyl palmitate levels. Moreover we show that although mouse epidermal cells metabolize retinoic acid at a very high rate, they respond functionally by induction of tissue transglutaminase activity. Because this enzyme has been suggested to be involved in programmed cell death, we are presently investigating the possibility that it may be involved in the inhibition of carcinogenesis in mice fed pharmacological doses of RA.
KW  - animal models
KW  - beta-carotene
KW  - carcinogenesis
KW  - carcinoma
KW  - diets
KW  - inhibition
KW  - isomers
KW  - liver
KW  - promoters
KW  - retinoic acid
KW  - retinol
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - promoter region
KW  - promoter sequences
KW  - tretinoin
KW  - vitamin A
KW  - vitamin A acid
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413432&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Soy intake and cancer risk: a review of the in vitro and in vivo data.
AU  - Messina, M. J.
AU  - Persky, V.
AU  - Setchell, K. D. R.
AU  - Barnes, S.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 21
IS  - 2
SP  - 113
EP  - 131
SN  - 0163-5581
AD  - Messina, M. J.: National Cancer Institute, National Institutes of Health, (Bethesda, MD), USA.
N1  - Accession Number: 20001413395.  Publication Type: Journal Article.  Language: English.  Number of References: 112 ref. Registry Number: 60-18-4.  Subject Subsets: Human Nutrition
N2  - International variations in cancer rates have been attributed, at least in part, to differences in dietary intake. Recently, it has been suggested that consumption of soyfoods may contribute to the relatively low rates of breast, colon, and prostate cancers in countries such as China and Japan. Soybeans contain a number of anticarcinogens, and a recent National Cancer Institute workshop recommended that the role of soyfoods in cancer prevention be investigated. In this review, the hypothesis that soy intake reduces cancer risk is considered by examining relevant in vitro, animal, and epidemiological data. Soybeans are a unique dietary source of the isoflavone genistein, which possesses weak estrogenic activity and has been shown to act in animal models as an antiestrogen. Genistein is also a specific inhibitor of protein tyrosine kinases; it also inhibits DNA topoisomerases and other critical enzymes involved in signal transduction. In vitro, genistein suppresses the growth of a wide range of cancer cells, with IC50 values ranging from 5 to 40 µM (1-10 µg/ml). Of the 26 animal studies of experimental carcinogenesis in which diets containing soy or soybean isoflavones were employed, 17 (65%) reported protective effects. No studies reported soy intake increased tumor development. The epidemiological data are also inconsistent, although consumption of nonfermented soy products, such as soymilk and tofu, tended to be either protective or not associated with cancer risk; however, no consistent pattern was evident with the fermented soy products, such as miso. Protective effects were observed for both hormone- and nonhormone-related cancers. While a definitive statement that soy reduces cancer risk cannot be made at this time, there is sufficient evidence of a protective effect to warrant continued investigation.
KW  - animal models
KW  - carcinogenesis
KW  - colon
KW  - diets
KW  - epidemiology
KW  - in vitro
KW  - isoflavones
KW  - kinases
KW  - models
KW  - neoplasms
KW  - prevention
KW  - prostate
KW  - protection
KW  - reviews
KW  - soyabeans
KW  - tofu
KW  - tyrosine
KW  - China
KW  - Japan
KW  - Glycine (Fabaceae)
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - Developed Countries
KW  - OECD Countries
KW  - bean curd
KW  - cancers
KW  - People's Republic of China
KW  - risks
KW  - soyabean curd
KW  - soybean curd
KW  - soybeans
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413395&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The relations between cervical cancer and serological markers of nutritional status.
AU  - Potischman, N.
AU  - Hoover, R. N.
AU  - Brinton, L. A.
AU  - Swanson, C. A.
AU  - Herrero, R.
AU  - Tenorio, F.
AU  - Britton, R. C. de
AU  - Gaitan, E.
AU  - Reeves, W. C.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 21
IS  - 3
SP  - 193
EP  - 201
SN  - 0163-5581
AD  - Potischman, N.: Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001413216.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 7235-40-7, 57-88-5, 502-65-8, 68-26-8.  Subject Subsets: Human Nutrition
N2  - We evaluated whether differences in serological nutrient indicators between cases and controls were likely to be due to different usual levels for cases or to altered metabolism due to disease. Blood samples obtained as part of a case-control study of invasive cervical cancer conducted in Latin America were evaluated for case-control differences and for trends with stage of disease. Serum α- and β-carotene, cryptoxanthin, and α- and γ-tocopherol showed no trend with extent of disease, although Stage IV cases had lower α- and β-carotene values than did other cases. A slight trend of decreasing values with stage was observed for serum retinol, lycopene, and lutein. For cholesterol and triglyceride concentrations, an inverse trend was observed with stage of disease, which suggested a clinical effect of the disease on blood lipids. Adjustment for smoking, alcohol intake, or oral contraceptive use did not alter observed relations, nor was there evidence that the altered blood nutrient levels differed by histological type. These data suggest that serum values for some carotenoids from Stage I, II, and III cervical cancer are suitable for aetiological studies, but spurious results may be obtained if late-stage cases are included. Evidence of trends with severity of disease for cholesterol and triglycerides, and possibly for retinol, lycopene, and lutein, suggest that special attention be given to disease effects of these nutrients in studies of cervical cancer.
KW  - alcohol intake
KW  - beta-carotene
KW  - blood
KW  - blood chemistry
KW  - blood lipids
KW  - carotenoids
KW  - cervix
KW  - cholesterol
KW  - evaluation
KW  - lipids
KW  - lycopene
KW  - neoplasms
KW  - nutrients
KW  - nutritional state
KW  - oral contraceptives
KW  - retinol
KW  - tobacco smoking
KW  - triacylglycerols
KW  - vitamins
KW  - women
KW  - America
KW  - Latin America
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - alcohol consumption
KW  - axerophthol
KW  - cancers
KW  - lipins
KW  - nutritional status
KW  - tetraterpenoids
KW  - triglycerides
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413216&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary factors and second primary cancers: a follow-up of oral and pharyngeal cancer patients.
AU  - Day, G. L.
AU  - Shore, R. E.
AU  - Blot, W. J.
AU  - McLaughlin, J. K.
AU  - Austin, D. F.
AU  - Greenberg, R. S.
AU  - Liff, J. M.
AU  - Preston-Martin, S.
AU  - Sarkar, S.
AU  - Schoenberg, J. B.
AU  - Fraumeni, J. F., Jr.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 21
IS  - 3
SP  - 223
EP  - 232
SN  - 0163-5581
AD  - Day, G. L.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001413219.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 50-81-7, 68-26-8.  Subject Subsets: Human Nutrition
N2  - To investigate the possible relationship between dietary factors and the development of multiple primary cancer, a nested case-control study was carried out within a cohort of 1090 oral and pharyngeal cancer patients. This patient group, enrolled in 1984-1985 in a population-based case-control study conducted in four (state of New Jersey, metropolitan Atlanta, Los Angeles County and 2 counties in the San Francisco Bay area) areas of the United States, was followed up through June 1989 for the occurrence of second primary cancer. Information on a number of risk factors, including diet, ascertained from interviews conducted at baseline (1984-1985) and at follow-up were compared between 80 patients with histologically confirmed second primary cancers (39% in the upper aerodigestive tract, 32% in the lung, 29% elsewhere) and 189 sex- and survival-matched control patients free of second cancers. Although few significant trends emerged, the results were suggestive of a protective effect provided by higher intake of vegetables. Risk of second primary cancers was 40-60% lower among those with the highest levels of intake for total vegetables and most vegetable subgroups, including dark yellow, cruciferous, and green leafy vegetables and legumes. Risks were also nonsignificantly lower among those with high consumption of vitamin C and carotenoids, with the adverse effects of alcohol being most evident among heavy drinkers with low vitamin C or carotenoid intake. There was also some evidence of an interaction between smoking and vitamin C consumption, but numbers of nonsmokers were small. Among other dietary factors considered, positive associations were found with increasing consumption of meats, liver, and retinol. The findings suggest that dietary factors contribute along with alcohol and smoking to the excess risks of second primary cancers among patients with oral and pharyngeal cancers.
KW  - adverse effects
KW  - alcohol intake
KW  - ascorbic acid
KW  - carotenoids
KW  - consumption
KW  - diet studies
KW  - diets
KW  - drinkers
KW  - intake
KW  - interactions
KW  - leafy vegetables
KW  - legumes
KW  - liver
KW  - lungs
KW  - meat
KW  - mouth
KW  - neoplasms
KW  - pharynx
KW  - protection
KW  - retinol
KW  - risk factors
KW  - vegetables
KW  - USA
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - alcohol consumption
KW  - axerophthol
KW  - cancers
KW  - green vegetables
KW  - tetraterpenoids
KW  - United States of America
KW  - vegetable crops
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Daily observation of antibody levels among dengue patients detected by enzyme-linked immunosorbent assay (ELISA).
AU  - Ruechusatsawat, K.
AU  - Morita, K.
AU  - et al.
AU  - Tanaka, M. (
JO  - Japanese Journal of Tropical Medicine and Hygiene
JF  - Japanese Journal of Tropical Medicine and Hygiene
Y1  - 1994///
VL  - 22
IS  - 1
SP  - 9
EP  - 12
SN  - 0304-2146
AD  - Ruechusatsawat, K.: Arbovirus Research Unit, Virus Institute, National Institutes of Health, Nonthaburi, Thailand.
N1  - Accession Number: 19942027189.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Registry Number: 308067-58-5, 308067-57-4.  Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Tropical Diseases
N2  - Serial serum specimens from 48 dengue patients admitted to a hospital [in Thailand] on day 2, day 3, or day 4 post onset were examined sequentially by ELISA for laboratory diagnosis according to the criteria set by Innis et al., [American Journal of Tropical Medicine and Hygiene, 40, 418]. Cumulative ELISA positive rates among forty secondary dengue infection patients were 95% and 100% at day 6 and day 7 post onset, respectively while the ELISA positive rates at day 3, day 4, and day 5 were 17.5%, 37.5%, and 75%. Cumulative ELISA positive rates among eight primary dengue patients were 87.5% and 100% at day 6 and day 7 post onset, while the rates at day 4 and day 5 were 12.5% and 50%. Thus, in order to achieve better diagnostic efficiency according to the criteria, convalescent sera should be taken after the 6th day from the onset of the disease. Four out of 74 secondary infection patients, corresponding to 5% of the patients, showed poor response of dengue-specific IgM antibody (less than 10 units) even when discharged, indicating that both IgG and IgM examinations are necessary in secondary dengue infection. AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Serial serum specimens from 48 dengue patients admitted to hospital in Thailand on days 2, 3 or 4 post onset were examined sequentially by ELISA for laboratory diagnosis according to the criteria set by B.L. Innis et al. (1993) [American Journal of Tropical Medicine and Hygiene, 40: 418-427]. Cumulative ELISA positive rates among 40 secondary dengue infection patients were 95% and 100% at days 6 and 7 post onset, respectively, while the ELISA positive rates at days 3, 4 and 5 were 17.5%, 37.5% and 75%. Cumulative ELISA positive rates among 8 primary dengue patients were 87.5% and 100% at days 6 and 7 post onset, while the rates at days 4 and 5 were 12.5% and 50%. Thus, in order to achieve better diagnostic efficiency according to the criteria, convalescent sera should be taken after the 6th day from the onset of the disease. 4 out of 74 secondary patients, corresponding to 5% of the patients, showed poor response of dengue-specific IgM antibody (&lt;10 units) even when discharged, indicating that both IgG and IgM examinations are necessary in secondary dengue infection.
KW  - antibodies
KW  - arboviruses
KW  - Dengue
KW  - diagnosis
KW  - ELISA
KW  - human diseases
KW  - IgG
KW  - IgM
KW  - immune response
KW  - immunodiagnosis
KW  - immunoglobulins
KW  - serology
KW  - viral diseases
KW  - Asia
KW  - Thailand
KW  - dengue virus
KW  - Flavivirus
KW  - man
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - arthropod-borne viruses
KW  - enzyme linked immunosorbent assay
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunological reactions
KW  - serological diagnosis
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027189&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis.
AU  - Ji, J.
AU  - Hoffmann, J. S.
AU  - Loeb, L.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1994///
VL  - 22
IS  - 1
SP  - 47
EP  - 52
SN  - 0305-1048
AD  - Ji, J.: (L. Loeb) Laboratory of Molecular Genetics, National Institute of Aging, NIH, Baltimore, MD 21224, USA.
N1  - Accession Number: 19942006519.  Publication Type: Journal Article.  Language: English.  Registry Number: 9068-38-6. 
KW  - env gene
KW  - Mutations
KW  - Nucleic acids
KW  - Reverse transcriptase
KW  - Synthesis
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006519&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Folate and cancer: a review of the literature.
AU  - Glynn, S. A.
AU  - Albanes, D.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 22
IS  - 2
SP  - 101
EP  - 119
SN  - 0163-5581
AD  - Glynn, S. A.: National Cancer Institute, Cancer Prevention Studies Branch, National Institutes of Health, Rockville, MD 20852, USA.
N1  - Accession Number: 20001413375.  Publication Type: Journal Article.  Language: English.  Number of References: 97 ref. Registry Number: 59-30-3, 12001-76-2.  Subject Subsets: Human Nutrition
N2  - Folate, a water-soluble vitamin, part of the vitamin B complex, plays an important role in methylation reactions and DNA/RNA synthesis. This review examines the experimental and epidemiological evidence for the association between folate status and risk of cancer. Data have accumulated indicating that low folate status may promote carcinogenesis. Low folate levels are associated with cytogenetic abnormalities in vivo and in vitro. Findings from animal studies are conflicting and suggest that the effect of folate on neoplasia depends on factors such as the animal and tumor model, the type, timing, dose, and length of application of carcinogen, the stage of carcinogenesis, and the level and form of folate administered. Epidemiological studies examined the association between folate and cancer of the cervix, colorectum, lung, esophagus, and brain and suggest that low folate status may play an important role early in the neoplastic process. The potential for inhibition of precursor lesions in the cervix and colorectum, namely, cervical intraepithelial neoplasia and adenomatous polyps, respectively, is of particular interest. Additional research designed to clarify the role of folate in carcinogenesis is warranted.
KW  - brain
KW  - carcinogenesis
KW  - cervix
KW  - epidemiology
KW  - folic acid
KW  - in vitro
KW  - inhibition
KW  - lesions
KW  - lungs
KW  - neoplasms
KW  - nutrition
KW  - oesophagus
KW  - reviews
KW  - synthesis
KW  - vitamin B complex
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cerebrum
KW  - esophagus
KW  - folacin
KW  - folate
KW  - vitamin B
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of soybean, Vicia faba, and vitamin C on the carcinogenicity of DMBA.
AU  - El-Aaser, A. A.
AU  - Zakhary, N. I.
AU  - El-Guindy, S. M.
AU  - Hafiez, A. R. A.
AU  - Halawa, F.
AU  - Mokhtar, N.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 22
IS  - 2
SP  - 195
EP  - 200
SN  - 0163-5581
AD  - El-Aaser, A. A.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 20001413382.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 9001-78-9, 50-81-7.  Subject Subsets: Human Nutrition
N2  - A single dose of 10 mg of 7,12-dimethylbenz[a]anthracene (DMBA), administered to rats through intragastric intubation, was sufficient to induce many biochemical and histopathological changes in their mammary tissue. Significant increases were observed in the activity levels of the enzymes acid ribonuclease, 5-nucleotidase, alkaline phosphatase, and β-glucuronidase in mammary tissue homogenates of DMBA-treated rats after an experimental period of five months. Histopathological studies of the mammary tissue also revealed malignant epithelial tumors (cribriform carcinoma) induced among 85% of the treated rats, with an incidence of 4 tumors in 12 mammary glands. Nevertheless, administration of 30% soybean in the diet of rats or 5,000 ppm ascorbic acid in their drinking water in addition to DMBA revealed a significant chemoprotective effect against the carcinogenesis induced by DMBA alone. This chemoprotective effect was demonstrated by the normalization of the activity levels of the enzymes studied in mammary tissue homogenates, because most of the enzymes were maintained at near the levels in the control animals. The incidence and number of tumors were also decreased. Cribriform carcinoma was observed in 50% of the rats, and the incidence of the affected glands was 2 in 12 mammary glands among both groups. On the other hand, a less chemoprotective effect was observed due to Vicia faba administration.
KW  - alkaline phosphatase
KW  - animal models
KW  - ascorbic acid
KW  - carcinogenesis
KW  - carcinogens
KW  - carcinoma
KW  - diet
KW  - drinking water
KW  - faba beans
KW  - mammary glands
KW  - mammary tissue
KW  - neoplasms
KW  - soyabeans
KW  - Glycine (Fabaceae)
KW  - rats
KW  - Vicia
KW  - Vicia faba
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Vicia
KW  - alkaline phosphomonoesterase
KW  - broad beans
KW  - cancers
KW  - fava beans
KW  - field beans
KW  - horse beans
KW  - soybeans
KW  - tic beans
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Importance of supplemental vitamin C in determining serum ascorbic acid in controls from a cervical cancer case-control study: implications for epidemiological studies.
AU  - Rashmi Sinha
AU  - Frey, C. M.
AU  - Kammerer, W. G.
AU  - McAdams, M. J.
AU  - Norkus, E. P.
AU  - Ziegler, R. G.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1994///
VL  - 22
IS  - 3
SP  - 207
EP  - 217
SN  - 0163-5581
AD  - Rashmi Sinha: Epidemiology and Biostatistics Program, Division of Cancer Etiology, Nutritional Epidemiology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001413307.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Classification of individuals by their ascorbic acid intake was investigated in 493 control subjects from a cervical cancer case-control study. The influence of dietary and supplemental sources of ascorbic acid, and demographic and life-style factors, on serum ascorbic acid were examined. Usual dietary intakes of ascorbic acid were determined from a food frequency questionnaire and recent intakes from a 24-h recall taken at the time of blood collection. Vitamin supplement information was obtained at both times. Blood samples were obtained from 361 white (72% of those interviewed) and 132 black (56% of those interviewed) subjects. In a regression analysis, the factors found to predict serum ascorbic acid were total recent ascorbic acid intake, an indicator variable for supplement use, body mass index, number of cigarettes smoked per day, race, education, and age. Higher levels of serum ascorbic acid were found among older nonsmoking highly educated leaner white women. Consideration of supplements, in addition to dietary sources of ascorbic acid, improved correlation coefficients between serum ascorbic acid and usual ascorbic acid intake from 0.19 to 0.32 and between serum ascorbic acid and recent intake from 0.36 to 0.56. While only a 2-fold difference between the first and fourth quartiles of serum ascorbic acid was observed using recent dietary ascorbic acid without supplements, this range increased 6-fold with addition of supplement data. Epidemiological studies should consider the use of total ascorbic acid intakes from supplement and food sources to permit accurate classification of individuals.
KW  - anthropometric dimensions
KW  - ascorbic acid
KW  - blood
KW  - body measurements
KW  - cervix
KW  - classification
KW  - diet studies
KW  - diets
KW  - education
KW  - epidemiology
KW  - height
KW  - intake
KW  - neoplasms
KW  - questionnaires
KW  - sources
KW  - supplements
KW  - vitamin supplements
KW  - weight
KW  - anthropometric measurements
KW  - cancers
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413307&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - RNA tertiary structure of the HIV RRE domain II containing non-Watson-Crick base pairs GG and GA: molecular modeling studies.
AU  - Le, S. Y.
AU  - Pattabiraman, N.
AU  - Maizel, J. V. Jr
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1994///
VL  - 22
IS  - 19
SP  - 3966
EP  - 3976
SN  - 0305-1048
AD  - Le, S. Y.: Laboratory of Mathematical Biology, Division of Cancer Biology, Diagnosis and Centers, National Cancer Institute, NIH, Frederick, MD 21702, USA.
N1  - Accession Number: 19952001047.  Publication Type: Journal Article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - regulatory genes
KW  - structure
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001047&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Solid phase assays for the detection of inhibitors of HIV reverse transcriptase.
AU  - Gause, G. G.
AU  - Gonda, M. A.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1994///
VL  - 22
IS  - 19
SP  - 4018
EP  - 4019
SN  - 0305-1048
AD  - Gause, G. G.: Laboratory of Cell and Molecular Structure, Program Resources, Inc.\DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, PO Box B, Frederick, MD 21702, USA.
N1  - Accession Number: 19952001314.  Publication Type: Journal Article.  Language: English.  Registry Number: 9068-38-6. 
KW  - antiviral agents
KW  - assays
KW  - enzyme activity
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - reverse transcriptase
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001314&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3′-processing and choice of nucleophile by HIV-1 integrase.
AU  - Mazumder, A.
AU  - Gupta, M.
AU  - Pommier, Y.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1994///
VL  - 22
IS  - 21
SP  - 4441
EP  - 4448
SN  - 0305-1048
AD  - Mazumder, A.: (Y. Pommier) Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 37, Room 5C25, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001566.  Publication Type: Journal Article.  Language: English. 
KW  - analysis
KW  - genomes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - mutations
KW  - processing
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - integrase
KW  - long terminal repeat
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001566&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic mapping of the mouse prosaposin gene (Psap) to mouse chromosome 10.
AU  - Kozak, C. A.
AU  - Adamson, M. C.
AU  - Horowitz, M.
JO  - Genomics (San Diego)
JF  - Genomics (San Diego)
Y1  - 1994///
VL  - 23
IS  - 2
SP  - 508
EP  - 510
SN  - 0888-7543
AD  - Kozak, C. A.: Laboratory of Molecular Microbiology, National Institutes of Health, Building 4, Room 329, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950104243.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Agricultural Biotechnology
N2  - The prosaposin gene (Psap) was previously cloned from a mouse brain cDNA library. Psap was found to be linked to 6 markers on chromosome 10 and located between pore-forming protein (Pfp) and zinc finger protein, autosomal (Zfa) genes. This region of mouse chromosome 10 is syntenic with human chromosome 10q21-q22.
KW  - biotechnology
KW  - gene mapping
KW  - pores
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - prosaposin
KW  - synteny
KW  - zinc finger
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950104243&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Child health and nutrition: obesity and high blood cholesterol.
AU  - Ernst, N. D.
AU  - Obarzanek, E.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1994///
VL  - 23
IS  - 4
SP  - 427
EP  - 436
SN  - 0091-7435
AD  - Ernst, N. D.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951407607.  Publication Type: Journal Article.  Language: English.  Number of References: 93 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Available data confirm that obesity and high blood cholesterol levels in children from the USA are higher than optimal and that the benefit of reducing the prevalence of these conditions in childhood will be realized in adulthood. Current National Heart, Lung and Blood Institute-supported research and education activities focus on unanswered questions about the childhood predictors of transition to the obese state and the feasibility, efficacy and safety of long-term dietary intervention in children. The effects of school-based interventions including classroom curriculum and school environmental changes related to food intake, physical activity, tobacco use and dissemination of materials that promote nutrition and cardiovascular health in children and adolescents are discussed.
KW  - blood
KW  - children
KW  - cholesterol
KW  - obesity
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407607&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary intake patterns and sociodemographic factors in the atherosclerosis risk in communities study.
AU  - Shimakawa, T.
AU  - Sorlie, P.
AU  - Carpenter, M. A.
AU  - Dennis, B.
AU  - Tell, G. S.
AU  - Watson, R.
AU  - Williams, O. D.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1994///
VL  - 23
IS  - 6
SP  - 769
EP  - 780
SN  - 0091-7435
AD  - Shimakawa, T.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951406391.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - Dietary intake assessed by a food frequency questionnaire was examined in relation to race, sex and educational attainment using baseline data obtained from randomly selected samples of 15 800 middle-aged black and white men and women who participated in the Atherosclerosis Risk in Communities Study (USA). In almost all comparisons, higher educational attainment was associated with recommended dietary intake patterns-lower per energy intakes of meats, eggs, chicken with skin and whole milk and higher intakes of fruits, vegetables, fish, chicken without skin and low-fat milk. As expected from these food intake patterns, higher educational attainment was associated with lower intakes of saturated fatty acid and cholesterol and with higher intakes of dietary fibre and various micronutrients. Compared with women's diets, men's diets were slightly more atherogenic (in whites only) based upon Keys score and had lower micronutrient levels. Although there were large differences in the food intakes between blacks and whites, the differences in nutrient intakes were generally smaller. However, intakes of cholesterol and vitamin A were somewhat higher and intakes of saturated fatty acid, calcium and potassium were lower among blacks than in whites. This community-based study clearly demonstrated that regardless of race and sex, high educational attainment is associated with recommended dietary intake patterns. Continuing efforts to improve general educational level and to promote healthy dietary habits among those with low socioeconomic status are warranted.
KW  - atherosclerosis
KW  - diet
KW  - diet studies
KW  - education
KW  - ethnic groups
KW  - heart diseases
KW  - men
KW  - risk
KW  - socioeconomic status
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - arteriosclerosis
KW  - coronary diseases
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406391&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Febrile illness caused by parasites.
AU  - Mahanty, S.
JO  - Pediatric Annals
JF  - Pediatric Annals
Y1  - 1994///
VL  - 23
IS  - 8
SP  - 398
EP  - 404
SN  - 0090-4481
AD  - Mahanty, S.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950809242.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Helminthology; Protozoology
N2  - In this review article it is shown that almost all protozoal and helminth parasites that are associated with febrile illness are either tissue-invasive or reside in the bloodstream. A practical approach to evaluating fever in individuals presenting with suspected parasitic infections involves the division of the patients into 2 groups: those with or without accompanying eosinophilia. The importance of accurate historical records, targeted clinical examination, appropriate laboratory investigations, and an evaluation of the individual's immunological status are emphasized. Appropriate diagnostic tests for a number of parasitic diseases are discussed. It is shown that, in general, when a patient with a suspected parasitic disease presents with eosinophilia, a helminth infection should be expected; when eosinophilia is absent, then a protozoal infection is more likely.
KW  - blood
KW  - diagnosis
KW  - eosinophilia
KW  - fever
KW  - helminthoses
KW  - helminths
KW  - human diseases
KW  - parasites
KW  - parasitoses
KW  - pathology
KW  - patients
KW  - protozoal infections
KW  - reviews
KW  - tissues
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - parasitic diseases
KW  - parasitic infestations
KW  - parasitic worms
KW  - parasitosis
KW  - protozoal diseases
KW  - pyrexia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809242&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Eosinophilia caused by parasites.
AU  - Mawhorter, S. D.
JO  - Pediatric Annals
JF  - Pediatric Annals
Y1  - 1994///
VL  - 23
IS  - 8
SP  - 405
EP  - 413
SN  - 0090-4481
AD  - Mawhorter, S. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
N1  - Accession Number: 19950809243.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Helminthology
N2  - Eosinophilia associated with parasitic infections is reviewed and shown to be associated specifically with tissue invasion and the migration of helminths, the degree of eosinophilia being proportional to the degree of tissue invasion. Eosinophilia is defined as an absolute count of &gt;500 eosinophils/mm³ of peripheral blood, and immune mechanisms are proposed. The helminth parasites commonly associated with eosinophilia are listed, and the value of identifying eosinophilia as a screening test for various helminthoses is discussed. The importance of accurate historical records, clinical examination and appropriate laboratory tests in the evaluation of patients suspected of having parasitic infections is emphasized, with emphasis on eosinophilia-inducing parasitic infections that can be acquired in the USA.
KW  - blood
KW  - diagnosis
KW  - eosinophilia
KW  - eosinophils
KW  - helminthoses
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunology
KW  - parasite migration
KW  - parasites
KW  - reviews
KW  - screening
KW  - tissues
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - eosinophil leukocytes
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - screening tests
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809243&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Parasitic causes of diarrhea.
AU  - Kenney, R. T.
JO  - Pediatric Annals
JF  - Pediatric Annals
Y1  - 1994///
VL  - 23
IS  - 8
SP  - 414
EP  - 422
SN  - 0090-4481
AD  - Kenney, R. T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950809244.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology; Helminthology
N2  - In a review of parasitic causes of chronic diarrhoea, it is shown that indigenous parasites remain a problem in several areas of the USA. The protozoa responsible for most cases include Giardia lamblia [G. duodenalis], Entamoeba histolytica, Balantidium coli, Cryptosporidium parvum, Enterocytozoon bieneusi and Blastocystis hominis. The helminths responsible include Trichuris trichiura, Trichinella spiralis, Strongyloides stercoralis, Schistosoma and Ancylostoma caninum. The pathology, clinical manifestations and treatment of each infection are reviewed, and concern is expressed that most antidiarrhoeal compounds are not approved for children younger than 2-3 years because of the higher risk of adverse effects. This has compromised treatment since parasites transmitted by the faecal-oral route are particularly troublesome in institutional settings and day-care centres for young children.
KW  - child care
KW  - children
KW  - day care centres
KW  - diagnosis
KW  - diarrhoea
KW  - gastrointestinal diseases
KW  - helminthoses
KW  - helminths
KW  - human diseases
KW  - parasites
KW  - pathology
KW  - protozoal infections
KW  - reviews
KW  - symptoms
KW  - treatment
KW  - USA
KW  - Ancylostoma caninum
KW  - Balantidium coli
KW  - Blastocystis hominis
KW  - Cryptosporidium parvum
KW  - Enoplida
KW  - Entamoeba histolytica
KW  - Enterocytozoon bieneusi
KW  - Giardia duodenalis
KW  - man
KW  - protozoa
KW  - Rhabditida
KW  - Schistosoma
KW  - Strongyloides stercoralis
KW  - Trichinella spiralis
KW  - Trichuris trichiura
KW  - Ancylostoma
KW  - Ancylostomatidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Balantidium
KW  - Balantidiidae
KW  - Vestibuliferida
KW  - Ciliophora
KW  - Protozoa
KW  - Blastocystis
KW  - Amoebida incertae sedis
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Cryptosporidium
KW  - Cryptosporidiidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Entamoeba
KW  - Endamoebidae
KW  - Enterocytozoon
KW  - Enterocytozoonidae
KW  - Microspora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - Strongyloides
KW  - Strongyloididae
KW  - Trichinella
KW  - Trichinellidae
KW  - Trichinellida
KW  - Dorylaimia
KW  - Enoplea
KW  - Trichuris
KW  - Trichuridae
KW  - Enoplia
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Adenophorea
KW  - day care centers
KW  - day centres
KW  - diarrhea
KW  - nematodes
KW  - parasitic worms
KW  - protozoal diseases
KW  - scouring
KW  - Secernentea
KW  - Strigeida
KW  - Strongylida
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809244&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Psychosocial work environment and health in U.S. Metropolitan areas: a test of the demand-control and demand-control-support models.
AU  - Muntaner, C.
AU  - Schoenbach, C.
JO  - International Journal of Health Services
JF  - International Journal of Health Services
Y1  - 1994///
VL  - 24
IS  - 2
SP  - 337
EP  - 353
SN  - 0020-7314
AD  - Muntaner, C.: Department of Health and Human Services, National Institutes of Health, Federal Building, Room B1A-12, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050225.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Public Health
KW  - Occupational health
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - metropolitan areas
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050225&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hypertrehalosemic hormone effects on transcriptional activity in the fat body of the cockroach, Blaberus discoidalis.
AU  - Lee YingHue
AU  - Keeley, L. L.
JO  - Insect Biochemistry and Molecular Biology
JF  - Insect Biochemistry and Molecular Biology
Y1  - 1994///
VL  - 24
IS  - 4
SP  - 357
EP  - 362
SN  - 0965-1748
AD  - Lee YingHue: Room 3E24, Building 37, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950500050.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 14875-96-8.  Subject Subsets: Medical & Veterinary Entomology
N2  - Gene expression was examined in the fat body of adult males of B. discoidalis in response to the hypertrehalosaemic hormone (HTH). HTH regulates a natural peak of haeme synthesis in the fat body at day 4 of adult life. Inhibition of transcriptional activity by α-amanitin suppressed both the natural increase in haeme biosynthesis at day 4, and the increase that was induced in decapitated insects by HTH administration. In contrast, the regimen of α-amanitin treatments that suppressed HTH-responsive haeme biosynthesis had no effect on the ability of HTH to increase haemolymph carbohydrate. HTH administration to decapitated animals produced a 25% increase in total fat body RNA and a 3-fold increase in [3H]uridine incorporation. In vitro translation of fat body RNA showed that HTH increased the synthesis of polypeptides at 24, 60 and 77 kDa. The results suggest that HTH affects fat body haeme synthesis through gene expression, and evidence was obtained for 3 polypeptides that increase in the fat body in response to HTH.
KW  - arthropod hormones
KW  - biochemistry
KW  - fat body
KW  - gene expression
KW  - haem
KW  - metabolism
KW  - molecular genetics
KW  - Blaberidae
KW  - Blaberus discoidalis
KW  - Blattaria
KW  - Dictyoptera
KW  - Blattaria
KW  - Dictyoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Blaberus
KW  - Blaberidae
KW  - biochemical genetics
KW  - Blattodea
KW  - heme
KW  - hypertrehalosaemic hormone
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950500050&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of drug-related genotypic changes in HIV-1 from serum using the selective polymerase chain reaction.
AU  - Anderson, B. D.
AU  - Shirasaka, T.
AU  - Kojima, E.
AU  - Yarchoan, R.
AU  - Mitsuya, H.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1994///
VL  - 25
IS  - 3/4
SP  - 245
EP  - 258
SN  - 0166-3542
AD  - Anderson, B. D.: Experimental Retrovirology Section, Medicine Branch, Division of Cancer Treatment, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005498.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
KW  - analogues
KW  - antiviral agents
KW  - diagnosis
KW  - drug resistance
KW  - HIV infections
KW  - human diseases
KW  - mutations
KW  - nucleoside analogues
KW  - nucleosides
KW  - polymerase chain reaction
KW  - therapy
KW  - treatment
KW  - analogs
KW  - human immunodeficiency virus infections
KW  - nucleoside analogs
KW  - PCR
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005498&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Formation of a minichromosome in Cryptococcus neoformans as a result of electroporative transformation.
AU  - Varma, A.
AU  - Kwon-Chung, K. J.
JO  - Current Genetics
JF  - Current Genetics
Y1  - 1994///
VL  - 26
IS  - 1
SP  - 54
EP  - 61
SN  - 0172-8083
AD  - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201229.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A minichromosome of approx. 270 kb was generated following complementation using electroporative transformation of a ura5 mutant strain of C. neoformans with the plasmid pURA5g2. The minichromosome occurred at a relatively high (&gt;20%) frequency in transformants that were stable for uracil prototrophy. The minichromosome was maintained in linear form as a large extrachromosomal element of the normal karyotype. Gel-purified DNA from the minichromosome readily transformed the ura5 mutant of C. neoformans. Southern-blot analysis of the minichromosome revealed the presence of multiple copies of the URA5 gene and ribosomal DNA sequences, in addition to containing telomere-like sequence repeats. The minichromosome was transmitted through mitosis and meiosis with extremely-high fidelity.
KW  - chromosomes
KW  - genetics
KW  - transformation
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201229&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variability in percent energy from fat throughout the day: implications for application of total diet goals.
AU  - Ballard-Barbash, R.
AU  - Thompson, F. E.
AU  - Graubard, B. I.
AU  - Krebs-Smith, S. M.
JO  - Journal of Nutrition Education
JF  - Journal of Nutrition Education
Y1  - 1994///
VL  - 26
IS  - 6
SP  - 278
EP  - 283
SN  - 0022-3182
AD  - Ballard-Barbash, R.: Applied Research Branch,Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951403095.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
N2  - In spite of the general agreement that dietary recommendations apply to the diet over time, the quantitative values for total and saturated fat have been used in establishing federal policy related to intakes for a single day, meal and even an individual food. Application of these recommendations uniformly to meals across a day implies that fat intake is uniform throughout the day. This analysis of the 1985 Continuing Survey of Food Intakes by Individuals demonstrates that percent energy intake from fat across eating occasions within a day is not uniform. Percent energy intake from total and saturated fat is lower at the morning meals and at snacks among women at all amounts of fat consumption, suggesting that fat is restricted more often at these 2 eating occasions. Intake of total and saturated fat was also more variable at these 2 eating occasions. These findings suggest that restricting fat intake at these eating occasions and liberalizing fat intake at midday and evening meals occurs commonly and may be an effective fat-reduction strategy. Daily variability in percent energy from fat should be considered in designing dietary fat reduction interventions and in applying quantitative recommendations for percent energy from total and saturated fat in nutrition guidance directed to individual meals.
KW  - diet
KW  - energy intake
KW  - fats
KW  - guidelines
KW  - nutrition
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - recommendations
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403095&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Radiation as adjunctive therapy to cystectomy for bladder cancer: is there a difference for bilharzial association?
AU  - Zaghloul, M. S.
T2  - International Journal of Radiation Oncology Biology Physics
JO  - International Journal of Radiation Oncology Biology Physics
JF  - International Journal of Radiation Oncology Biology Physics
Y1  - 1994///
VL  - 28
IS  - 3
SP  - 783
EP  - 783
SN  - 0360-3016
AD  - Zaghloul, M. S.: Radiotherapy Department, National Cancer Institute, El Khalig, Cairo, Egypt.
N1  - Accession Number: 19950803551.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Subject Subsets: Helminthology
N2  - Following the article by Reisinger et al. in International Journal of Radiation, Oncology and Biological Physics (1993) 25, 153-154 on the survival of bladder cancer patients treated with cystectomy and adjuvant radiotherapy, the results of this treatment are compared in patients with schistosomal and non-schistosomal bladder cancer. The main differences appeared to be in the late presentation of bladder cancer in patients with Schistosoma infection, thought to be due to the overlap of schistosomal and neoplastic symptoms, the predominance of the squamous variety of neoplasm, the higher male predominance, and the younger age group at presentation. The effect of these differences on the management and treatment of cases of bladder cancer are discussed.
KW  - bladder diseases
KW  - carcinoma
KW  - helminths
KW  - human diseases
KW  - neoplasms
KW  - parasites
KW  - pathology
KW  - radiotherapy
KW  - schistosomiasis
KW  - surgical operations
KW  - treatment
KW  - Digenea
KW  - man
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - cancers
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803551&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alterations in mRNA expression of duodenal 1,25-dihydroxyvitamin D3 receptor and vitamin D-dependent calcium binding protein in aged Wistar rats.
AU  - Liang, C. T.
AU  - Barnes, J.
AU  - Imanaka, S.
AU  - Luca, H. F. de
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1994///
VL  - 29
IS  - 2
SP  - 179
EP  - 186
SN  - 0531-5565
AD  - Liang, C. T.: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19951410499.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 32222-06-3, 1406-16-2.  Subject Subsets: Human Nutrition
N2  - The steady state mRNA levels of duodenal calcitriol receptor and calcium binding protein (CaBP) were examined in both adult (6) and old (24-month-old) rats. 1 major band of 4.4 kb for calcitriol receptor mRNA was identified. The size of the transcript was not affected by age. The content of calcitriol receptor mRNA (normalized with poly(A) +RNA) decreased 23% in the aged as compared to the adult rat. The expression of CaBP was also examined. A single band of 0.6 kb was observed for CaBP mRNA. The size of CaBP mRNA was not altered with age. However, the abundance of CaBP mRNA (normalized with poly(A) +RNA) was reduced 20% in the senescent rat. Thus, results were consistent with previous findings that the number of calcitriol receptors and the level of CaBP declined in the aged rat. However, the precise mechanism leading to the age-related deficit in mRNA expression remains to be elucidated.
KW  - age
KW  - aging
KW  - calcitriol
KW  - calcium binding proteins
KW  - duodenum
KW  - gene expression
KW  - receptors
KW  - vitamin D
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 1,25-dihydroxycholecalciferol
KW  - 1,25-dihydroxyvitamin D
KW  - ageing
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410499&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical and pharmacological factors causing induction and suppression of germination of Trichosporon beigelii.
AU  - Walsh, T. J.
AU  - Kelly, P.
AU  - Peebles, R.
AU  - Lee, J.
AU  - Lecciones, J.
AU  - Pizzo, P. A.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1994///
VL  - 32
IS  - 2
SP  - 123
EP  - 132
SN  - 0268-1218
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200702.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Biochemical and pharmacological factors that may regulate germination of T. beigelii were investigated. Germination was significantly enhanced by temp. of 37°C, chemically defined cell culture media such as RPMI-1640, plasma, physiological pH, N-acetylglucosamine and proline. N-acetylglucosamine was equivalent to proline in inducing germination. Germination was suppressed by high concn of glucose, increasing inocula, low pH and amphotericin B at achievable serum concn. It is concluded that many of the factors regulating germination of T. beigelii are similar to those for Candida albicans.
KW  - germination
KW  - morphogenesis
KW  - Trichosporon beigelii
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200702&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum D-arabinitol measured by automated quantitative enzymatic assay for detection and therapeutic monitoring of experimental disseminated candidiasis: correlation with tissue concentrations of Candida albicans.
AU  - Walsh, T. J.
AU  - Lee, J. W.
AU  - Sien, T.
AU  - Schaufele, R.
AU  - Bacher, J.
AU  - Switchenko, A. C.
AU  - Goodman, T. C.
AU  - Pizzo, P. A.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1994///
VL  - 32
IS  - 3
SP  - 205
EP  - 215
SN  - 0268-1218
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethseda, MD 20892, USA.
N1  - Accession Number: 19941201049.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 1397-89-3, 2152-56-9, 86386-73-4, 2022-85-7, 79404-91-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - Serum levels of D-arabinitol were measured by rapid automated enzymatic assay in rabbits with experimental disseminated candidosis. The enzymatic reaction steps were performed on a standard automated clinical chemistry analyser. As a correction for renal impairment, data were expressed as serum D-arabinitol/creatinine ratio (DA/Cr). Serum creatinine concn were determined from the same sample with the same instrument, thus allowing rapid determination of the DA/Cr within one laboratory. The DA/Cr was determined in 321 samples from 132 rabbits. The mean serum DA/Cr in 31 normal non-infected rabbits was 1.51±0.2 µM/mg per dl. Among 84 rabbits with disseminated candidosis and pre-terminal samples, there was a direct correlation between DA/Cr and tissue concn of C. albicans (r=0.80; P&lt;0.001). A threshold of elevated DA/Cr (≥3.0 µM/mg per dl) was evident in rabbits with a tissue concn of C. albicans≥3 × 104 colony forming units (CFU)/g. Elevated DA/Cr was detected in 48 (89%) of 54 rabbits at a C. albicans tissue concn of ≥3 × 104 CFU/g vs. 1 (3%) of 30 rabbits with &lt;3 × 104 CFU/g (P&lt;0.0001). Among all 101 rabbits with disseminated candidosis, an elevated DA/Cr was detected at any point during infection in 60 (92%) of 65 rabbits having a C. albicans tissue concn ≥3 × 104 CFU/g vs. 13 (36%) of 36 rabbits with &lt;3 × 104 CFU/g (P&lt;0.0001). The relationship between the tissue response to antifungal therapy (amphotericin B, flucytosine, fluconazole, SCH 39304 or cilofungin) and change in DA/Cr was further analysed. Ten (91%) of 11 rabbits with a tissue-proven response to antifungal therapy (defined as ≥10²-fold reduction of CFU/g in comparison to untreated controls) had a &gt;50% reduction in elevated DA/Cr levels. By comparison, 10 (83%) of 12 treated rabbits with no response to therapy had persistently elevated DA/Cr levels (P&lt;0.001). It is concluded that these findings further indicate that serial DA/Cr measurements may be useful for diagnosis and therapeutic monitoring of disseminated candidosis.
KW  - amphotericin B
KW  - arabinitol
KW  - candidosis
KW  - cilofungin
KW  - diagnosis
KW  - drug therapy
KW  - experimental infections
KW  - fluconazole
KW  - flucytosine
KW  - generalized infections
KW  - infections
KW  - serum
KW  - therapy
KW  - Candida albicans
KW  - mice
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - 5-fluorocytosine
KW  - candidiasis
KW  - chemotherapy
KW  - fungus
KW  - Hyphomycetes
KW  - SCH 39304
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of Candida casts in experimental renal candidiasis: implications for the diagnosis and pathogenesis of upper urinary tract infection.
AU  - Navarro, E. E.
AU  - Almario, J. S.
AU  - King, C.
AU  - Bacher, J.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1994///
VL  - 32
IS  - 6
SP  - 415
EP  - 426
SN  - 0268-1218
AD  - Navarro, E. E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200925.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The diagnostic yield, methods for detection and pathogenesis of Candida cast formation were studied in serially collected urine specimens from immunologically intact and granulocytopenic rabbit models of haematogenous disseminated C. albicans infection. Refractile blastoconidia and pseudohyphae of Candida encased in the granular matrix were seen on wet mounts while Candida stained a brilliant red in the fuchsia pink tubular matrix on periodic acid-Schiff (PAS) stained cytopathology filters. Among 24 rabbits with disseminated candidosis, 11 (46%) had Candida casts detectable by wet mount and PAS stained urine filters in comparison to none of 10 non-infected immunologically normal controls (P=0.014). 15 (70%) of 21 episodes of Candida casts were detected within the first 3 d of infection, indicating possible utility in the early diagnosis of renal candidosis. No Candida casts were detected in the urine of granulocytopenic rabbits, possibly due to the rapid destruction of tubules and abrogation of cast formation. This absence of detectable Candida in 8 infected granulocytopenic rabbits differed significantly from that of 24 non-granulocytopenic infected rabbits, in which Candida casts were detected in 11 (46%) (P=0.029). Candida cast formation occurred predominantly in the cortex. Histopathological examination demonstrated invasion of Candida into the glomerular tufts and peritubular capillaries, followed by development of Candida casts in the proximal and distal tubules, respectively. It is concluded that detection of renal Candida casts may be a useful diagnostic marker in distinguishing upper versus lower urinary tract candidosis.
KW  - candidosis
KW  - detection
KW  - diagnosis
KW  - experimental infections
KW  - generalized infections
KW  - immunocompromised hosts
KW  - infections
KW  - kidneys
KW  - pathogenesis
KW  - techniques
KW  - urinary tract
KW  - urine
KW  - Candida albicans
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - candidiasis
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200925&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development and evaluation of a rapid and simple procedure for detection of Pneumocystis carinii by PCR.
AU  - Cartwright, C. P.
AU  - Nelson, N. A.
AU  - Gill, V. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1994///
VL  - 32
IS  - 7
SP  - 1634
EP  - 1638
SN  - 0095-1137
AD  - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951201897.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology; Public Health
N2  - A simplified PCR-based assay for the detection of P. carinii DNA in clinical specimens was developed. The adoption of a rapid DNA extraction procedure and the introduction of a type of ELISA for PCR product detection enabled this procedure to be carried out in a single working day in a clinical microbiology laboratory. The PCR assay was prospectively compared with an immunofluorescent-antibody (FA) staining method for the detection of P. carinii in induced sputum and bronchoalveolar lavage (BAL) specimens. Results showed that, for induced sputum specimens, FA staining had a sensitivity of 78% (32 of 41 specimens) and a specificity of 100% (166 of 166); PCR was 100% sensitive (41 of 41) and 98% specific (162 of 166). For BAL specimens, FA staining was 100% sensitive (21 of 21 specimens) and 100% specific (133 of 133), and PCR had a sensitivity of 100% (21 of 21) and a specificity of 99% (132 of 133). It is suggested that use of the PCR-based assay could effect clinically useful improvements in the sensitivity of induced sputum specimens for the detection of P. carinii.
KW  - detection
KW  - diagnosis
KW  - human diseases
KW  - infections
KW  - lungs
KW  - mycoses
KW  - parasites
KW  - pneumocystis carinii pneumonia
KW  - pneumocystosis
KW  - pneumonia
KW  - polymerase chain reaction
KW  - sputum
KW  - techniques
KW  - fungi
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - fungus
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxicity and carcinogenicity of riddelliine following 13 weeks of treatment to rats and mice.
AU  - Chan, P. C.
AU  - Mahler, J.
AU  - Bucher, J. R.
AU  - Travlos, G. S.
AU  - Reid, J. B.
JO  - Toxicon (Oxford)
JF  - Toxicon (Oxford)
Y1  - 1994///
VL  - 32
IS  - 8
SP  - 891
EP  - 908
SN  - 0041-0101
AD  - Chan, P. C.: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19950304253.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9007-49-2.  Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Riddelliine, a pyrrolizidine alkaloid isolated from Senecio riddellii (collected from rangeland in USA), is implicated in the poisoning of livestock, and is known to contaminate human food sources. Riddelliine was administered to rats and mice (p.o.) for 13 weeks. Body weight gains were inversely proportional to riddelliine dose, and treated animals exhibited liver damage; adenomas were observed in some rats. In separate studies, riddelliine (150 mg/kg) stimulated the frequency of micronucleated erythrocytes in the peripheral blood of male mice, and riddelliine (25 mg/kg) increased unscheduled DNA synthesis in primary hepatocytes of rats and mice.
KW  - adenoma
KW  - biosynthesis
KW  - carcinogens
KW  - DNA
KW  - liver
KW  - neoplasms
KW  - plant composition
KW  - poisonous plants
KW  - pyrrolizidine alkaloids
KW  - toxic substances
KW  - toxicology
KW  - USA
KW  - animals
KW  - Asteraceae
KW  - mice
KW  - plants
KW  - rats
KW  - Senecio riddellii
KW  - eukaryotes
KW  - Asterales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Senecio
KW  - Asteraceae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - chemical constituents of plants
KW  - deoxyribonucleic acid
KW  - poisons
KW  - toxic plants
KW  - United States of America
KW  - Plant Composition (FF040) 
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Weeds and Noxious Plants (FF500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950304253&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transfusion of blood components to persons infected with human immunodeficiency virus type 1: relationship to opportunistic infection.
AU  - Sloand, E.
AU  - Kumar, P.
AU  - Klein, H. G.
AU  - Merritt, S.
AU  - Sacher, R.
JO  - Transfusion
JF  - Transfusion
Y1  - 1994///
VL  - 34
IS  - 1
SP  - 48
EP  - 53
SN  - 0041-1132
AD  - Sloand, E.: National Heart, Lung and Blood Institute, National Institutes of Medicine, Bethesda, MD, USA.
N1  - Accession Number: 19941200802.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - The records of 196 HIV-1-infected patients in the USA with CD4 lymphocyte counts &lt;250 cells/mm³ were reviewed to determine if there were more opportunistic infections in subjects who previously received transfusions than in those who had not received transfusions. The decline in CD4 cells was also compared and the frequency of transfusion reactions and red cell alloantibodies was assessed. The frequency of cytomegalovirus (CMV), wasting and bacterial infections (P&lt;0.01), but not of Pneumocystis carinii pneumonia (PCP) (P&lt;0.2), was significantly increased in patients who had previously received transfusions. This effect was independent of CD4 count, race or risk factor. The frequency of CMV infection, but not of PCP, was also related to the number of units of blood received (P&lt;0.01). Significant bacterial infections occurred primarily in persons with CMV infection, of whom there were more in the transfusion cohort. When analysed separately in the group of patients without CMV infection, the frequency of bacterial infection was unrelated to transfusion. Other opportunistic infections were less common but included Candida, Cryptococcus neoformans, Toxoplasma, Cryptosporidium and Mycobacterium avium-intracellulare infections as well as miliary tuberculosis. The death rate in those who received transfusions was greater than that in patients who had never received a transfusion. None of the 130 patients who received red cell transfusions developed red cell alloantibodies. It is concluded that there is a relationship between transfusion and virus activation in AIDS patients and the potential benefits of modifying the preparation of blood components should be investigated.
KW  - acquired immune deficiency syndrome
KW  - Bacterial diseases
KW  - Blood products
KW  - blood transfusion
KW  - candidosis
KW  - cryptococcosis
KW  - cryptosporidiosis
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - lungs
KW  - Mortality
KW  - opportunistic infections
KW  - parasites
KW  - Pneumocystis carinii pneumonia
KW  - pneumocystosis
KW  - pneumonia
KW  - predisposition
KW  - toxoplasmosis
KW  - USA
KW  - Candida
KW  - Cryptococcus neoformans
KW  - Cryptosporidium
KW  - Cytomegalovirus
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - Toxoplasma
KW  - Toxoplasma gondii
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Cryptosporidiidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Sarcocystidae
KW  - Toxoplasma
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - candidiasis
KW  - death rate
KW  - european blastomycosis
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ivermectin in human medicine.
AU  - Ottesen, E. A.
AU  - Campbell, W. C.
JO  - Journal of Antimicrobial Chemotherapy
JF  - Journal of Antimicrobial Chemotherapy
Y1  - 1994///
VL  - 34
IS  - 2
SP  - 195
EP  - 203
SN  - 0305-7453
AD  - Ottesen, E. A.: Clinical Parasitology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950810233.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 70288-86-7.  Subject Subsets: Helminthology
N2  - Current concepts about the pharmacokinetics and biochemical mode of action of ivermectin are reviewed as is clinical evidence which may suggest additional uses in human medicine, under the headings: pharmacology and mode of action; clinical studies; filarial infections other than onchocerciasis (Wuchereria bancrofti, Brugia malayi, Loa loa, Mansonella perstans, M. ozzardi); gastrointestinal parasites (Ascaris lumbricoides, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, hookworm, cutaneous larva migrans, ectoparasites).
KW  - anthelmintics
KW  - drug therapy
KW  - ectoparasites
KW  - filariids
KW  - helminths
KW  - hookworms
KW  - human diseases
KW  - ivermectin
KW  - larva migrans
KW  - mode of action
KW  - onchocerciasis
KW  - parasites
KW  - pharmacokinetics
KW  - pharmacology
KW  - reviews
KW  - Ascaris lumbricoides
KW  - Brugia malayi
KW  - Enoplida
KW  - Enterobius vermicularis
KW  - Loa loa
KW  - man
KW  - Mansonella ozzardi
KW  - Mansonella perstans
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Trichuris trichiura
KW  - Wuchereria bancrofti
KW  - Ascaris
KW  - Ascarididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Brugia
KW  - Onchocercidae
KW  - Enterobius
KW  - Oxyuridae
KW  - Loa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Mansonella
KW  - Strongyloides
KW  - Strongyloididae
KW  - Trichuris
KW  - Trichuridae
KW  - Trichinellida
KW  - Dorylaimia
KW  - Enoplea
KW  - Wuchereria
KW  - Enoplia
KW  - Adenophorea
KW  - African eyeworm
KW  - Ascaridida
KW  - chemotherapy
KW  - creeping eruption
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - pinworm
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - threadworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of amphotericin B and fluconazole on platelet membrane glycoproteins.
AU  - Sloand, E. M.
AU  - Kumar, P.
AU  - Yu, M.
AU  - Klein, H. G.
JO  - Transfusion
JF  - Transfusion
Y1  - 1994///
VL  - 34
IS  - 5
SP  - 415
EP  - 420
SN  - 0041-1132
AD  - Sloand, E. M.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201883.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The effects of amphotericin B and fluconazole on platelet membrane glycoproteins (GP) were examined by incubation of split aliquots of fresh and stored platelet concentrates (PCs) in storage bags with these drugs for 3 d. To determine the effect of storage, PCs were stored for 5 d and aliquots removed on days 1-5 were placed in platelet storage bags with 4 µg/ml amphotericin B for 2-6 h. Membrane glycoprotein expression was assessed by flow cytometry with fluorescein isothiocyanate-labelled monoclonal antibodies (MoAbs) directed against the following antigens: GPIb (CD42b), CD63 (an activation protein), P-selectin (CD62) and GPIIb/IIIa (CD41a). Amphotericin B produced a concn-dependent decrease in the surface binding of CD42b MoAb with no consistent changes in the binding of CD41a, CD63 or CD62 MoAbs after a 3-d exposure. Stored but not fresh PCs showed decreased binding of MoAb CD42b after a 6-h exposure to amphotericin B (4 µg/ml). Fluconazole produced no changes. When the binding of MoAb CD42b to permeabilized platelets was used to measure total platelet content, amphotericin B (4 µg/ml) decreased MoAb CD42b binding to a similar degree in fresh and stored platelets. Inhibition of aggregation to ADP and collagen and ADP and epinephrine was seen in stored but not fresh PCs. Therapeutic levels of amphotericin B resulted in partial loss of total platelet GPIb in fresh and stored PCs, but decreased surface expression on platelet membrane GPIb only in stored platelets. It is suggested that this difference between fresh and stored platelets may be related to the limited reservoir of GPIb available for redistribution to the membrane in the previously stored PCs and may account for the decreased recovery of transfused platelets observed in some patients receiving amphotericin B.
KW  - amphotericin B
KW  - antifungal agents
KW  - drug toxicity
KW  - platelets
KW  - toxicity
KW  - blood platelets
KW  - fungistats
KW  - thrombocytes
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit.
AU  - Robins, E. D.
AU  - Nelson, L. M.
AU  - Hoeg, J. M.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1994///
VL  - 35
IS  - 1
SP  - 52
EP  - 59
SN  - 0022-2275
AD  - Robins, E. D.: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20852, USA.
N1  - Accession Number: 19941412845.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 57-83-0.  Subject Subsets: Human Nutrition
N2  - WHHL and NZW rabbits were compared with regard to oocyte morphology and fertilization rates after stimulation with equine chorionic gonadotropin. Hypothalamic-pituitary-ovarian axis function was also examined by measuring baseline and gonadotropin releasing hormone-stimulated plasma oestradiol, progesterone and gonadotropin concentrations, before and after simvastatin inhibition of de novo cholesterol synthesis. WHHL rabbit oocytes remained encased in cumulus and had a lowered fertilization rate (9/50 vs. 83/87, P&lt;0.05). WHHL rabbits had lower baseline oestradiol concentrations (7.1±0.72 vs. 10.2±0.94, P&lt;0.05) and had higher baseline follicle stimulating hormone (P&lt;0.05) and luteinizing hormone (P&lt;0.05) concentrations. Simvastatin lowered luteal progesterone concentrations only in WHHL rabbits (P&lt;0.05). It is concluded that the hypothalamic-pituitary-ovarian axis in WHHL rabbits is abnormal. The reduced availability of intracellular cholesterol for progesterone synthesis by inhibition of de novo cholesterol synthesis leads to a significant reduction in plasma progesterone concentrations in the WHHL. The findings have implications for women with familial hypercholesterolaemia, particularly regarding treatment with inhibitors of de novo cholesterol synthesis.
KW  - female animals
KW  - gonadotropins
KW  - hypercholesterolaemia
KW  - hyperlipaemia
KW  - oestrogens
KW  - oocytes
KW  - progesterone
KW  - sex hormones
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - estrogens
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - hyperlipemia
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.
AU  - Chao, F. F.
AU  - Blanchette-Mackie, E. J.
AU  - Dickens, B. F.
AU  - Gamble, W.
AU  - Kruth, H. S.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1994///
VL  - 35
IS  - 1
SP  - 71
EP  - 83
SN  - 0022-2275
AD  - Chao, F. F.: Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941412846.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Early developing atherosclerotic lesions were examined to assess when unesterified cholesterol-rich lipid particles (UCLP) appear and when they become enriched in cholesterol and sphingomyelin. Cholesterol-fed NZW rabbits, which rapidly develop atherosclerotic lesions, and genetically hyperlipaemic WHHL rabbits, which develop lesions over a longer period of time, were studied. UCLP of peak density (d) 1.04 g/ml appear as early as 4 weeks after the onset of cholesterol feeding and progressively accumulate during atherosclerotic lesion development. Beginning with their appearance and afterwards, UCLP contain a saturating level (2:1 molar ratio) of cholesterol relative to phospholipid. Whereas, early UCLP are enriched in phosphatidylcholine, with time UCLP become enriched with sphingomyelin. Another UCLP population having a peak density of 1.09 g/ml was present in control aortas and increased in amount more slowly than the d 1.04 g/ml UCLP during cholesterol feeding. The d 1.09 g/ml particles were predominantly unilamellar vesicles, the majority between 100 and 200 nm in diameter. They contained &gt;90% of their cholesterol in unesterified form and their ratio of unesterified cholesterol to phospholipid progressively increased from 0.6 to 1.7 during cholesterol feeding. Liposome resistance to solubilization by high density lipoproteins is known to be increased by enrichment with unesterified cholesterol and sphingomyelin. Sphingomyelin enrichment of UCLP could stabilize cholesterol in a form that does not readily crystallize. However, at the same time, the early and progressive accumulation of UCLP in developing atherosclerotic lesions may limit reverse cholesterol transport and accelerate disease progression.
KW  - atherosclerosis
KW  - cardiovascular diseases
KW  - cholesterol
KW  - intake
KW  - lipoproteins
KW  - liposomes
KW  - phospholipids
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A novel missense mutation in the C-terminal domain of lipoprotein lipase (Glu410-&gt;Val) leads to enzyme inactivation and familial chylomicronemia.
AU  - Previato, L.
AU  - Guardamagna, O.
AU  - Dugi, K. A.
AU  - Ronan, R.
AU  - Talley, G. D.
AU  - Santamarina-Fojo, S.
AU  - Brewer, H. B., Jr.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1994///
VL  - 35
IS  - 9
SP  - 1552
EP  - 1560
SN  - 0022-2275
AD  - Previato, L.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7N115, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941412836.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9004-02-8.  Subject Subsets: Human Nutrition
KW  - hyperchylomicronaemia
KW  - lipoprotein lipase
KW  - mutations
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - diacylglycerol lipase
KW  - hyperchylomicronemia
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism.
AU  - Ikewaki, K.
AU  - Rader, D. J.
AU  - Zech, L. A.
AU  - Brewer, H. B., Jr.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1994///
VL  - 35
IS  - 10
SP  - 1809
EP  - 1819
SN  - 0022-2275
AD  - Ikewaki, K.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951400828.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Subject Subsets: Human Nutrition
N2  - A study was conducted to: elucidate the metabolic basis of the low apoprotein (apo)A-I values in abetalipoproteinaemia (ABL); examine whether in vivo apoE production rates are normal in the absence of apoB-lipoprotein secretion; and to test the hypothesis that apoE influences apoA-I and HDL catabolism in ABL. 131I-labelled apoA-I and 125I-labelled apoE were reassociated with autologous lipoproteins and injected into 2 unrelated ABL patients and control subjects. The mean residence time of apoA-I in ABL (2.4 days) was significantly decreased by nearly 50% compared with control subjects (4.7±0.6 days). ApoA-I production rates were also significantly decreased by 40% in ABL (7.1) compared with control subjects (11.8±1.7 mg kg-1 day-1). The mean residence time of apoE in ABL (0.50 days) was somewhat shorter than that of control subjects (0.66 ± 0.15 days), whereas the mean apoE production rate in ABL (2.14) was not substantially different from that of control subjects (1.55±0.62 mg kg-1 day-1). HDL subfractions LpA-I and LpA-I:A-II were isolated using immunoaffinity chromatography. In contrast to the normal metabolism, apoA-I in LpA-I:A-II particles was catabolized at a faster rate than apoA-I in LpA-I, accounting for the greater decrease of plasma LpA-I:A-II relative to LpA-I in the ABL patients. HDL subfractions without and with apoE were also isolated using anti-apoE immunoaffinity chromatography. Labelled apoA-I in apoE-containing HDL was catabolized faster than that in HDL without apoE. Among the 3 different forms of apoE, the apoE monomer was catabolized at the fastest rate, the apoE homodimer at an intermediate rate and the apoE-A-II heterodimer had the slowest rate of catabolism. It is concluded that decreased apoA-I values in ABL are due to a decreased rate of apoA-I production as well as an increased rate of apoA-I catabolism, in particular that of apoA-I in LpA-I:A-II. Despite the lack of secretion of apoB-containing lipoproteins, apoE production is not impaired in ABL. These results provide insight into the role of apoB and apoE in HDL metabolism.
KW  - abetalipoproteinaemia
KW  - apolipoproteins
KW  - high density lipoprotein
KW  - lipid metabolism
KW  - metabolism
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - abetalipoproteinemia
KW  - fat metabolism
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope kinetic study.
AU  - Vergès, B.
AU  - Rader, D.
AU  - Schaefer, J.
AU  - Zech, L.
AU  - Kindt, M.
AU  - Fairwell, T.
AU  - Gambert, P.
AU  - Brewer, H. B., Jr.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1994///
VL  - 35
IS  - 12
SP  - 2280
EP  - 2291
SN  - 0022-2275
AD  - Vergès, B.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951405196.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Human Nutrition
KW  - apolipoproteins
KW  - high density lipoprotein
KW  - hypertriglyceridaemia
KW  - low density lipoprotein
KW  - metabolism
KW  - very high density lipoprotein
KW  - very low density lipoprotein
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hypertriglyceridemia
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405196&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occupational risks for colon cancer in Sweden.
AU  - Chow, W. H.
AU  - Malker, H. S. R.
AU  - Hsing, A. W.
AU  - McLaughlin, J. K.
AU  - Weiner, J. A.
AU  - Stone, B. J.
AU  - Ericsson, J. L. E.
AU  - Blot, W. J.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1994///
VL  - 36
IS  - 6
SP  - 647
EP  - 651
SN  - 0096-1736
AD  - Chow, W. H.: National Cancer Institute, Division of Cancer Etiology, Epidemiology and Biostatistics Program, Bethesda, Maryland, USA.
N1  - Accession Number: 19952005675.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Public Health
N2  - Using the Cancer-Environment Registry of Sweden, which links census information (1960) with cancer incidence data (1961 to 1979), the authors conducted a systematic, population-based assessment of colon cancer incidence among cohorts defined by industry and occupation for all employed persons in Sweden. Small but statistically significant excesses of colon cancer were observed among white-collar occupations, including administrators, professionals, and clerical and sales workers, whereas a reduction in incidence was found among workers in agricultural and related jobs, such as farmers, fishermen and hunters. Analysis by subsite within the colon revealed little difference in results. The observed risk patterns are consistent with previous reports on colon cancer risk and occupational physical activity levels, ie, elevated risk among sedentary white-collar workers and reduced risk among agricultural workers. Few craftsman and production processing jobs were linked to colon cancer, although statistically significant excesses were observed among shoe and leather workers, metal smiths, and foundry workers in the metal manufacturing industry. The findings indicate that occupation in general is likely to play a relatively small role in colon cancer aetiology with perhaps its major contribution an indirect one via physical activity.
KW  - colon
KW  - colon cancer
KW  - human diseases
KW  - neoplasms
KW  - occupational hazards
KW  - occupational health
KW  - occupations
KW  - Europe
KW  - Sweden
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancer sites
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005675&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occupational cancer mortality among women employed in the telephone industry.
AU  - Dosemeci, M.
AU  - Blair, A.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1994///
VL  - 36
IS  - 11
SP  - 1204
EP  - 1209
SN  - 0096-1736
AD  - Dosemeci, M.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952004235.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Public Health
N2  - A mortality odds ratio (MOR) analysis among women employed in the telephone industry was conducted using death certificates from 24 reporting states of the USA for 1984 through 1989. Usual occupation and industry from the death certificates were coded using the 1980 Bureau of the Census occupational and industrial classification system. There were 2444 cancer deaths among women in the telephone industry (code 441). Among younger (age &lt;49) white women, significant excess risks were observed from cancers of the rectum (MOR = 3.3; 95% confidence interval [CI] = 1.2 to 8.7), connective tissue (MOR = 4.4; 95% CI = 2.2 to 8.8), breast (MOR = 1.6; 95% CI = 1.3 to 2.1), corpus uteri (MOR = 3.3; 95% CI 1.5 to 7.5), ovary (MOR = 2.1; 95% CI = 1.3 to 3.5), and brain (MOR = 2.1; 95% CI = 1.2 to 3.7). Cancer of the connective tissue showed an almost sixfold risk (MOR = 5.5; 95% CI = 2.0 to 14.8) for the age group of 30 to 39 years. Excess risk of cancer of the connective tissue were observed among engineers and technicians, office workers, telephone operators, and mechanics and repairers (MOR = 8.5, 4.9, 1.7, and 4.4, respectively), suggesting a possible relationship with modern technological exposures in the telephone industry. Risks for cancers of the breast, corpus uteri, ovary, and brain were also elevated among these jobs. The authors did not have information on other risk factors for these cancer sites; therefore, socioeconomic status or lifestyle may explain these observed associations, particularly for the cancers of the reproductive system. Possible exposure to new instruments, machinery, or production procedures introduced in the modern telephone industry also may account for excess risks observed, particularly among younger women.
KW  - human diseases
KW  - neoplasms
KW  - occupational hazards
KW  - occupations
KW  - telephones
KW  - women
KW  - workers
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Occupational Health and Safety (VV900) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004235&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk of multiple myeloma by occupation and industry among men and women: a 24-state death certificate study.
AU  - Figgs, L. W.
AU  - Dosemeci, M.
AU  - Blair, A.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1994///
VL  - 36
IS  - 11
SP  - 1210
EP  - 1221
SN  - 0096-1736
AD  - Figgs, L. W.: Occupational Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19952004236.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref. Subject Subsets: Public Health
N2  - This cancer surveillance investigation used death certificates from 24 USA states for the period 1984-1989 to identify multiple myeloma and occupation associations and to stimulate hypotheses. A case-control study of multiple myeloma was created from 3 159 417 certificates in which 12 148 male and female cases were frequency matched by age, race, and gender with five controls per case. The authors screened 231 industries and 509 occupations. Women demonstrated significant excess risk among managers and administrators, post-secondary teachers, elementary teachers, social workers, other sales workers, waitresses, and hospital maids. Men showed significant risks among computer system scientists, veterinarians, elementary teachers, authors, engineering technicians, general office supervisors, insurance adjusters, barbers, electronic repairers, supervisors of extracting industries, production supervisors, photoengravers, and grader/dozer operators. Male and female elementary school teachers demonstrated the most consistent, statistically significant increased risk of multiple myeloma.
KW  - human diseases
KW  - myeloma
KW  - occupational hazards
KW  - occupations
KW  - risk assessment
KW  - workers
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - United States of America
KW  - Occupational Health and Safety (VV900) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mortality from gastric cardia and lower esophagus cancer and occupation.
AU  - Ward, M. H.
AU  - Dosemeci, M.
AU  - Cocco, P.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1994///
VL  - 36
IS  - 11
SP  - 1222
EP  - 1227
SN  - 0096-1736
AD  - Ward, M. H.: Occupational Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA.
N1  - Accession Number: 19952004237.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Public Health
N2  - The incidence of adenocarcinoma of the gastric cardia and oesophagus is increasing steadily in the USA. Little is known about the aetiology of these cancers. The authors used occupation and industry information on the death certificates from 24 states (1984 to 1989) to conduct a case-control analysis of gastric cardia and gastric cardia/lower oesophagus cancer. Risks were also calculated for other gastric cancers combined. Controls were deaths from other causes except cancer and gastrointestinal disorders. Increased risks of gastric cardia and cardia/lower oesophagus among white women were found for administrative jobs (cardia odds ratio (OR) = 3.9; 95% confidence interval (CI), 1.5-9.8) and health professionals (cardia OR = 1.8; 95% CI, 0.6-5.3). Occupations associated with a lower socioeconomic status showed no significant excess risks. A similar pattern in risks was seen for men.
KW  - human diseases
KW  - mortality
KW  - neoplasms
KW  - occupational hazards
KW  - occupational health
KW  - occupations
KW  - stomach
KW  - workers
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004237&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dose-dependent antifungal activity and nephrotoxicity of amphotericin B colloidal dispersion in experimental pulmonary aspergillosis.
AU  - Allende, M. C.
AU  - Lee, J. W.
AU  - Francis, P.
AU  - Garrett, K.
AU  - Dollenberg, H.
AU  - Berenguer, J.
AU  - Lyman, C. A.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1994///
VL  - 38
IS  - 3
SP  - 518
EP  - 522
SN  - 0066-4804
AD  - Allende, M. C.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200980.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety and efficacy of amphotericin B colloidal dispersion (ABCD) for the treatment of invasive pulmonary aspergillosis in persistently granulocytopenic rabbits were investigated. Treatment groups included ABCD in dosages of 1, 5 and 10 mg/kg daily intravenously or conventional desoxycholate amphotericin B (DAmB) at 1 mg/kg daily intravenously. Antifungal activity was directly related to increasing dosage of ABCD as determined by the concn of Aspergillus fumigatus organisms in lungs and the frequency of haemorrhagic pulmonary lesions. At 5 and 10 mg/kg daily, there was a significant reduction in the tissue burden of A. fumigatus as measured by percent culture-positive lobes and colony forming units (CFU)/gram of tissue (P≤0.001), whereas at 1 mg/kg daily the tissue burden of A. fumigatus was not significantly different from that in untreated controls. Microbiological clearance was significantly greater at 1 mg/kg of DAmB daily than at 1 mg/kg of ABCD daily (P≤0.001). There was no difference in microbiological clearance of bronchoalveolar lavage fluid among the treatment groups as measured by CFU/ml. As determined by survival, ABCD at 5.0 mg/kg daily was more effective than DAmB at 1.0 mg/kg daily and ABCD at 10 mg/kg daily. ABCD at 10 mg/kg daily was more nephrotoxic than the lower dosages of ABCD and resulted in higher mortality. Impairment of glomerular filtration developed as a direct function increasing the ABCD dosage (r=0.77, P&lt;0.001). It is concluded that this study found dose-dependent antifungal activity and nephrotoxicity of ABCD against invasive pulmonary aspergillosis in persistently granulocytopenic rabbits and showed that the optimal dosage of ABCD for antifungal activity and safety was 5 mg/kg.
KW  - administration
KW  - amphotericin B
KW  - aspergillosis
KW  - drug formulations
KW  - drug therapy
KW  - drug toxicity
KW  - experimental infections
KW  - infections
KW  - kidneys
KW  - lipids
KW  - lungs
KW  - therapy
KW  - toxicity
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - chemotherapy
KW  - fungus
KW  - Hyphomycetes
KW  - lipins
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmacokinetics and safety of a unilamellar liposomal formulation of amphotericin B (AmBisome) in rabbits.
AU  - Lee, J. W.
AU  - Amantea, M. A.
AU  - Francis, P. A.
AU  - Navarro, E. E.
AU  - Bacher, J.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1994///
VL  - 38
IS  - 4
SP  - 713
EP  - 718
SN  - 0066-4804
AD  - Lee, J. W.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200863.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - A unilamellar liposomal formulation of amphotericin B (LAmB, AmBisome) was safely administered intravenously to 20 rabbits at 0.5, 1.0, 2.5, 5 or 10 mg/kg of body wt, whereas of 12 rabbits given desoxycholate amphotericin B (DAmB) intravenously at 0.5, 1.0 or 1.5 mg/kg, 2 died of acute cardiac toxicity when DAmB was administered at the highest dose. Single-dose LAmB (1 mg/kg) achieved a max. concn in serum (Cmax) of 26±2.4 µg/ml and an area under the curve to infinity (AUC0-∞) of 60±16 µg.h/ml, while single-dose DAmB (1.0 mg/kg), by comparison, achieved a lower Cmax (4.7±0.2 µg/ml; P=0.001) and a lower AUC0-∞ (30.6±2.2 µg.h/ml; P=0.07). following administration of a single dose of LAmB (10 mg/kg), a disproportionately higher Cmax (287±14 µg/ml) and AUC0-∞ (2223±246 µg.h/ml) occurred, indicating saturable elimination. After chronic dosing (n=4) with LAmB at 5.0 mg/kg daily for 28 d or DAmB at 1.0 mg/kg daily for 28 d, LAmB achieved daily peak levels of 122.8±5.8 µg/ml and trough levels of 34.9±1.8 µg/ml, while DAmB reached a peak of only 1.76±0.11 µg/ml and trough levels of 0.46±0.04 µg/ml (P≤0.001). Significant accumulations of amphotericin B into reticuloendothelial organs were observed, with 239±39 µg/g found in the liver after chronic LAmB dosing (5 mg/kg daily), which was 7-fold higher than the 33±6 µg/g after DAmB dosing (1 mg/kg daily). Accumulation in kidneys, however, remained 14-fold lower (P=0.04) following LAmB dosing (0.87±0.61 µg/g) than after DAmB dosing (12.7±4.6 µg/g). Nephrotoxicity occurred in only 1 of 4 LAmB-treated animals, while it occurred in all 4 chronically DAmB-treated animals; mild hepatotoxicity with transaminase elevations was seen in 1 LAmB-treated rabbit. It is concluded that LAmB safely achieves higher Cmaxs and AUC0-∞s and demonstrates saturable, non-linear elimination from plasma via reticuloendothelial organ uptake. The reduced nephrotoxicity of LAmB correlated with diminished levels of amphotericin B in the kidneys.
KW  - administration
KW  - amphotericin B
KW  - drug formulations
KW  - kidneys
KW  - liposomes
KW  - liver
KW  - pharmacokinetics
KW  - toxicity
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins.
AU  - Kageyama, S.
AU  - Anderson, B. D.
AU  - et al.
AU  - Hoesterey, B. L. (
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1994///
VL  - 38
IS  - 5
SP  - 1107
EP  - 1111
SN  - 0066-4804
AD  - Kageyama, S.: (H. Mitsuya) Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050080.  Publication Type: Journal Article.  Language: English. 
KW  - Antiviral agents
KW  - binding
KW  - human immunodeficiency viruses
KW  - Inhibition
KW  - proteinase inhibitors
KW  - proteins
KW  - Serum
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - KNI-272
KW  - protease inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050080&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Itraconazole for experimental pulmonary aspergillosis: comparison with amphotericin B, interaction with cyclosporin A, and correlation between therapeutic response and itraconazole concentrations in plasma.
AU  - Berenguer, J.
AU  - Ali, N. M.
AU  - Allende, M. C.
AU  - Lee, J.
AU  - Garrett, K.
AU  - Battaglia, S.
AU  - Piscitelli, S. C.
AU  - Rinaldi, M. G.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1994///
VL  - 38
IS  - 6
SP  - 1303
EP  - 1308
SN  - 0066-4804
AD  - Berenguer, J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200895.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 1397-89-3, 79217-60-0, 84625-61-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - Itraconazole and amphotericin B were compared by using a newly developed model of invasive pulmonary aspergillosis in rabbits immunosuppressed with methylprednisolone and cyclosporin A (CsA). Both itraconazole at 40 mg/kg (given orally) and amphotericin B at 1 mg/kg (given intravenously) had in vivo antifungal activity in comparison with controls. At these dosages, amphotericin B was more effective than itraconazole in reducing the tissue burden (log10 colony forming units/g) of Aspergillus fumigatus (P&lt;0.05) and the number of pulmonary lesions (P&lt;0.01). However, there was considerable variation in the near-peak concn of itraconazole in plasma (median, 4.15 µg/ml; range, &lt;0.5 to 16.8 µg/ml) and a strong inverse correlation between concn of itraconazole in plasma and the tissue burden of A. fumigatus. An inhibitory sigmoid maximum-effect model predicted a significant pharmacodynamic relationship (r=0.87, P&lt;0.001) between itraconazole concn in plasma and antifungal activity as a function of the tissue burden of A. fumigatus. This model demonstrated that levels in plasma of &gt;6 µg/ml were associated with a significantly greater antifungal effect. Levels in plasma of &lt;6 µg/ml were associated with a rapid decline in the antifungal effect. Itraconazole, in comparison with amphotericin B, caused a 2-fold elevation of CsA levels (P&lt;0.01) but was less nephrotoxic (P&lt;0.01). This study of experimental pulmonary aspergillosis demonstrated that amphotericin B at 1 mg/kg daily was more active but more nephrotoxic than itraconazole at 40 mg/kg daily, that itraconazole increased concn of CsA in plasma, and that the antifungal activity of itraconazole strongly correlated with concn in plasma in an inhibitory sigmoid maximum-effect model. It is concluded that these findings further indicate the importance of monitoring concn of itraconazole in plasma as a guide to increasing dosage, improving bioavailability and optimizing antifungal efficacy in the treatment of invasive pulmonary aspergillosis.
KW  - amphotericin B
KW  - antagonism
KW  - aspergillosis
KW  - cyclosporins
KW  - drug antagonism
KW  - drug therapy
KW  - experimental infections
KW  - infections
KW  - itraconazole
KW  - lungs
KW  - pharmacokinetics
KW  - therapy
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - chemotherapy
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmacokinetics and safety of weekly dapsone and dapsone plus pyrimethamine for prevention of pneumocystis pneumonia.
AU  - Falloon, J.
AU  - Lavelle, J.
AU  - Ogata-Arakaki, D.
AU  - Byrne, A.
AU  - Graziani, A.
AU  - Morgan, A.
AU  - Amantea, M. A.
AU  - Ownby, K.
AU  - Polis, M.
AU  - Davey, R. T. Jr
AU  - Kovacs, J. A.
AU  - Lane, H. C.
AU  - Masur, H.
AU  - MacGregor, R. R.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1994///
VL  - 38
IS  - 7
SP  - 1580
EP  - 1587
SN  - 0066-4804
AD  - Falloon, J.: LIR, NIAID, National Institutes of Health, Building 10, Room 11C-103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050467.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 80-08-0, 58-14-0.  Subject Subsets: Medical & Veterinary Mycology; Protozoology
N2  - The safety and pharmacokinetics of weekly dapsone and weekly dapsone plus pyrimethamine were examined in adult patients with HIV infection in the USA who were at risk for Pneumocystis carinii pneumonia because of a prior episode or a CD4+ T-cell count &lt;250 cells/mm³. Groups of patients received 100, 200 and 300 mg of dapsone as a single weekly dose. The maximum tolerated dose of weekly dapsone was established as 200 mg/wk in patients receiving at least 500 mg of zidovudine concomitantly. This dose of dapsone was then found to be well tolerated when combined with pyrimethamine at 25 mg. Further patients were randomized to dapsone at 200 mg or dapsone at 200 mg plus pyrimethamine at 25 mg once weekly. 26 patients each were followed for a median of 33 wk on dapsone alone and 45 wk on the combination. Seven patients in each group withdrew because of toxicity. Five patients receiving dapsone developed documented Pneumocystis pneumonia, while 4 and 2 patients receiving dapsone plus pyrimethamine developed documented and presumptive Pneumocystis pneumonia, respectively. To evaluate the tolerability of a higher dose of pyrimethamine, 11 patients had their regimen changed to dapsone at 200 mg plus pyrimethamine at 75 mg, which was well tolerated by 10 of the patients for a median period of 11 wk. The pharmacokinetics of dapsone and pyrimethamine were examined using a population pharmacokinetic model. Decreases in the apparent volume of the peripheral compartment were observed when multiple-dose regimens of dapsone were compared with single-dose dapsone and when multiple-dose regimens of dapsone plus pyrimethamine were compared with multiple dapsone alone. It is concluded that when administered weekly, dapsone at 200 mg and dapsone at 200 mg with pyrimethamine at 25 mg are both well tolerated regimens. It is suggested that the efficacy of these regimens in preventing Pneumocystis pneumonia may be less than that of trimethoprim-sulfamethoxazole.
KW  - acquired immune deficiency syndrome
KW  - antifungal agents
KW  - antiprotozoal agents
KW  - dapsone
KW  - drug combinations
KW  - HIV infections
KW  - hosts
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - mycoses
KW  - opportunistic infections
KW  - parasites
KW  - pharmacokinetics
KW  - Pneumocystis carinii pneumonia
KW  - pneumocystosis
KW  - pneumonia
KW  - prophylaxis
KW  - pyrimethamine
KW  - treatment
KW  - USA
KW  - fungi
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - protozoa
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - invertebrates
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro and ex vivo effects of cyclosporin A on phagocytic host defenses against Aspergillusfumigatus.
AU  - Roilides, E.
AU  - Robinson, T.
AU  - Sein, T.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1994///
VL  - 38
IS  - 12
SP  - 2883
EP  - 2888
SN  - 0066-4804
AD  - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951202317.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 59865-13-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The effects of ciclosporin A (CsA) on phagocytic defences against A. fumigatus were studied in vitro and ex vivo. After incubation with 10-250 ng/ml of CsA at 37°C for 60 min, polymorphonuclear leukocytes (PMNs) exhibited unaltered superoxide anion (O2-) production in response to phorbol myristate acetate and N-formylmethionyl leucyl phenylalanine, whereas ≥500 ng/ml significantly suppressed it (P&lt;0.01). Moreover, at &lt;250 ng/ml of CsA, PMNs exhibited no change in their capacity to damage unopsonized hyphae of A. fumigatus compared with controls, whereas at ≥250 ng/ml, CsA suppressed the function (P&lt;0.01). Although neither CsA (250 ng/ml) nor hydrocortisone (10 µg/ml) suppressed PMN O2- production in response to phorbol myristate acetate and N-formylmethionyl leucyl phenylalanine, combination of the 2 agents reduced the function compared with that at the baseline (P&lt;0.05). Incubation of monocytes with 100 ng/ml of CsA for 1 or 2 d suppressed their anti-hyphal activity. No essential change in phagocytic activity of monocyte-derived macrophages (MDMs) against A. fumigatus conidia, tested as the percentage of phagocytosing MDMs and mean number of MDM-associated conidia, was detected after 2 or 4 d of incubation with 10-1000 ng/ml of CsA. Furthermore, in rabbits treated with CsA (up to 20 mg/kg of body wt daily intravenously for 7 d), neither O2- production and hyphal damage caused by PMNs or monocytes against hyphae nor phagocytosis of conidia by pulmonary alveolar macrophages was significantly suppressed. It is concluded that CsA within therapeutically relevant concn does not suppress antifungal activity of phagocytes except that of circulating monocytes. However, it may induce significant immunosuppression of phagocyte antifungal function at relatively high concn in vitro, especially when combined with corticosteroids.
KW  - ciclosporin
KW  - immunology
KW  - monocytes
KW  - phagocytes
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - cyclosporin
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202317&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin A in epithelial differentiation and skin caracinogenesis.
AU  - Luca, L. M. de
AU  - Darwiche, N.
AU  - Celli, G.
AU  - Kosa, K.
AU  - Jones, C.
AU  - Ross, S.
AU  - Chen, L. C.
JO  - Scandinavian Journal of Nutrition/Näringsforskning
JF  - Scandinavian Journal of Nutrition/Näringsforskning
Y1  - 1994///
VL  - 38
IS  - SUP 27
SP  - 45
EP  - 52
SN  - 1102-6480
AD  - Luca, L. M. de: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951408214.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 32 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Relations between the role of vitamin A in epithelial differentiation and skin carcinogenesis are reviewed and discussed in an attempt to understand the steps involved in the neoplastic process and to develop clinical strategies to control neoplastic progression.
KW  - carcinogenesis
KW  - differentiation
KW  - epithelium
KW  - retinol
KW  - reviews
KW  - skin
KW  - vitamins
KW  - Sweden
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - axerophthol
KW  - dermis
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Vitamin A: from nuclear biology to public health
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408214&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The uptake and metabolism of cysteine by Giardia lamblia trophozoites.
AU  - Lujan, H. D.
AU  - Nash, T. E.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1994///
VL  - 41
IS  - 2
SP  - 169
EP  - 175
SN  - 1066-5234
AD  - Lujan, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950800665.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 52-90-4.  Subject Subsets: Protozoology
N2  - The cysteine, cystine, methionine and sulfate uptake and cysteine metabolism of Giardia lamblia [Giardia duodenalis] were studied. The analysis of radiolabelled L-cysteine uptake indicated the presence of at least 2 different transport systems. The total cysteine uptake was non-saturable, with a capacity of 3.7 pmoles/106 cells/min/µM of cysteine, and probably represented passive diffusion. However, cysteine transport was partially inhibited by L-methionine, D-cysteine and DL-homocysteine, indicating that another system specific for SH-containing amino acids was also present. Cysteine uptake was markedly decreased in medium without serum. In contrast to cysteine, L-methionine and sulfate uptake were carried out by saturable systems with apparent Km of 71 and 72 µM, respectively, but the Vmax of sulfate uptake was 6 orders of magnitude lower than the Vmax of methionine uptake. Cystine was not incorporated into trophozoites. [35S]-labelled L-cysteine and L-methionine, but not [35S]sulfate, were incorporated into Giardia proteins, indicating that the parasite lacks the capacity to synthesize cysteine or methionine from sulfate. Neither cystathionine γ lyase nor crystathionine γ synthase activity was detected in homogenates of Giardia, suggesting that the transsulfuration pathway is not active and that there is no conversion of methionine to cysteine. The data indicate that cysteine is essential for Giardia because the parasite cannot take up cystine and cannot synthesize cysteine de novo.
KW  - amino acids
KW  - biochemistry
KW  - cysteine
KW  - in vitro
KW  - metabolism
KW  - parasites
KW  - uptake
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800665&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The journey of malaria sporozoites in the mosquito salivary gland.
AU  - Pimenta, P. F.
AU  - Touray, M.
AU  - Miller, L.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1994///
VL  - 41
IS  - 6
SP  - 608
EP  - 624
SN  - 1066-5234
AD  - Pimenta, P. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950805814.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The fine structure of the invasive process of Aedes aegypti salivary glands by malarial parasites is described. Plasmodium gallinaceum sporozoites start the invasion process by attaching to and crossing the basal lamina and then penetrating the host plasma membrane of the salivary cells. The penetration process appeared to involve the formation of membrane junctions. Once inside the host cells, the sporozoites were seen within vacuoles attached by their anterior end to the vacuolar membrane. Mitochondria surrounded, and were closely associated with, the invading sporozoites. After the disruption of the membrane vacuole, the parasites traversed the cytoplasm, attached to, and invaded the secretory cavity through the apical plasma membrane of the cells. Inside the secretory cavity, sporozoites were seen again inside vacuoles. Upon escaping from these vacuoles, sporozoites were positioned in parallel arrays forming large bundles attached by multi-lamellar membrane junctions. Several sporozoites were seen around and inside the secretory duct. Except for the penetration of the chitinous salivary duct, these observations have morphologically characterised the entire process of sporozoite passage through the salivary gland.
KW  - disease vectors
KW  - host parasite relationships
KW  - invasion
KW  - parasites
KW  - sporozoites
KW  - ultrastructure
KW  - vectors
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - culicidae
KW  - diptera
KW  - Plasmodiidae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805814&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytomegalovirus/herpesvirus and carotid atherosclerosis: the ARIC study.
AU  - Sorlie, P. D.
AU  - Adam, E.
AU  - Melnick, S. L.
AU  - Folsom, A.
AU  - Skelton, T.
AU  - Chambless, L. E.
AU  - Barnes, R.
AU  - Melnick, J. L.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1994///
VL  - 42
IS  - 1
SP  - 33
EP  - 37
SN  - 0146-6615
AD  - Sorlie, P. D.: National Heart, Lung and Blood Institute, Federal Building, Room 3A10, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952006674.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Antibodies to CMV and herpes simplex virus type 1 (HSV1) and type 2 (HSV2) were determined in 340 matched case-control pairs from the Atherosclerosis Risk in Communities (ARIC) Study in the USA. Cases were defined by B-mode ultrasonography as persons with thickened carotid artery walls consistent with early atherosclerosis but without a history of cardiovascular disease. Controls were defined as persons without thickened walls or history of cardiovascular disease. The case-control odds ratio for CMV antibodies was 1.55 (P = 0.03), for HSV1 1.41 (P = 0.07), and for HSV2 0.91 (P = 0.63). When adjustment was made for potential confounders, the odds ratios were 1.36 for CMV (P = 0.24), 1.21 for HSV1 (P = 0.45), and 0.61 (P = 0.05) for HSV2. These results suggest a modest association between CMV and asymptomatic carotid wall thickening consistent with early atherosclerosis.
KW  - atherosclerosis
KW  - epidemiology
KW  - herpes simplex viruses
KW  - human diseases
KW  - human herpesviruses
KW  - infections
KW  - North America
KW  - USA
KW  - Human herpesvirus 5
KW  - man
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - arteriosclerosis
KW  - herpes simplex virus
KW  - human cytomegalovirus
KW  - Human herpesvirus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006674&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serological response to rotavirus infection in newborn infants.
AU  - Flores, J.
AU  - White, L.
AU  - Blanco, M.
AU  - Perez-Schael, I.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1994///
VL  - 42
IS  - 1
SP  - 97
EP  - 102
SN  - 0146-6615
AD  - Flores, J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003203.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - The authors report the identification of rotavirus in stools of newborn infants at the "Hospital Materno Infantil de Caricuao" (HMIC) in Caracas, Venezuela as well as the infants' serological responses to various rotavirus strains. The serological responses of another group of rotavirus-positive neonates studied previously at the "Maternidad Concepcion Palacios" (MCP) hospital was also evaluated. Fifty-four of 266 (20%) newborns examined at HMIC shed rotavirus. The infection rate was higher among infants admitted to the nursery (75%) than in those "rooming in" with their mothers (7%) (P &lt;0.01). Eleven of the 54 neonates (20%) had diarrhoea; seven of them experienced mild, short-lived episodes, whereas five had frequent bouts of diarrhoea or diarrhoea lasting for over 3 days; the remaining 43 infants were asymptomatic. Twenty-seven of 28 rotavirus specimens tested at HMIC had VP7 serotype 4 specificity and one belonged to VP7 serotype 1; VP4 typing performed on 24 of the viruses by RNA hybridization showed these viruses to be similar to the M37 strain, a rotavirus previously associated with asymptomatic infections in newborns at MCP. IgA seroresponses were detected in eight of 11 infants born at HMIC (73%), but most failed to develop neutralization responses to homologous or heterologous strains. Newborn infants who had shed the M37 rotavirus strain at MCP reacted similarly: 16 of 24 (67%) developed a rotavirus IgA rise, but only 29% developed a neutralization response.
KW  - human diseases
KW  - immune response
KW  - infections
KW  - neonates
KW  - South America
KW  - Venezuela
KW  - man
KW  - Reoviridae
KW  - rotavirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Reoviridae
KW  - America
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - South America
KW  - Threshold Countries
KW  - immunity reactions
KW  - immunological reactions
KW  - newborn infants
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003203&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of a human group C rotavirus in Malaysia.
AU  - Rasool, N. B. G.
AU  - Hamzah, M.
AU  - Jegathesan, M.
AU  - Wong, Y. H.
AU  - Qian, Y.
AU  - Green, K. Y.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1994///
VL  - 43
IS  - 3
SP  - 209
EP  - 211
SN  - 0146-6615
AD  - Rasool, N. B. G.: (K.Y. Green) Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051294.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - Stool specimens from 334 infants and young children hospitalized with diarrhoea in Kuala Lumpur, Malaysia between August and November, 1987 were analysed for the presence of rotavirus double-stranded (ds) RNA by polyacrylamide gel electrophoresis. Of the 334 specimens analysed, 32 (9.6%) were positive for rotavirus RNA. One specimen (designated G147) exhibited a ds RNA electropherotype profile characteristic of Group C rotavirus and was selected for further characterization. In Northern blot hybridization studies, the gene 5 segment of strain G147 hybridized with a cDNA probe generated from the cloned gene 5 (which encodes the VP6 inner capsid protein that is group specific) of porcine Group C rotavirus strain Cowden, confirming the classification of strain G147 in Group C. The association of Group C rotavirus with diarrhoeal illness in Malaysia is consistent with earlier studies that suggest a global distribution of this virus and supports the need for additional epidemiological studies.
KW  - children
KW  - epidemiology
KW  - infections
KW  - Asia
KW  - Malaysia
KW  - man
KW  - rotavirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - APEC countries
KW  - ASEAN Countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - Threshold Countries
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression of hepatitis B surface and core antigens and transforming growth factor-α in "oval cells" of the liver in patients with hepatocellular carcinoma.
AU  - Hsia, C. C.
AU  - Thorgeirsson, S. S.
AU  - Tabor, E.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1994///
VL  - 43
IS  - 3
SP  - 216
EP  - 221
SN  - 0146-6615
AD  - Hsia, C. C.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051296.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Recent studies have identified epithelial cell populations in human livers that are similar to the "oval cells" and "transitional cells" seen in rat livers during the early stages of chemical carcinogenesis. It has been suggested that these cells may theoretically be involved in hepatocarcinogenesis. The hepatitis B virus (HBV) is also believed to play a role in the aetiology of hepatocellular carcinoma (HCC). Therefore, a study was conducted in non-tumourous livers adjacent to HCCs obtained from 26 patients from China to determine whether HBV antigens could be identified in oval cells and transitional cells using an immunohistochemical technique. Hepatitis B surface antigen (HBsAg) was detected in the non-tumourous livers of 22/26 (85%) patients. HBsAg was detected in oval cells in 18/26 (69%), in transitional cells in 21/26 (81%), and in mature hepatocytes in 22/26 (85%), but not in bile duct or ductule cells. Transforming growth factor-α (TGF-α) was expressed in oval cells, transitional cells, and bile duct cells in 24/26 (92%) patients, and in mature hepatocytes in 25/26 (96%). Coexpression of HBsAg and TGF-α was identified in the same cells in populations of oval cells and transitional cells of selected patients. Because of the possibility that oval cells could be a source of evolving HCC, these findings suggest that expression of TGF-α associated with HBV infection of oval cells could be a mechanism of human hepatocarcinogenesis. Thus, oval cells could be a site (or one of the sites) where HBV participates in the development of HCC.
KW  - antigens
KW  - carcinoma
KW  - hepatitis B
KW  - hepatocellular carcinoma
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - antigenicity
KW  - immunogens
KW  - People's Republic of China
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051296&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Whole-body energy metabolism and skeletal muscle biochemical characteristics.
AU  - Zurlo, F.
AU  - Nemeth, P. M.
AU  - Choksi, R. M.
AU  - Sesodia, S.
AU  - Ravussin, E.
JO  - Metabolism, Clinical and Experimental
JF  - Metabolism, Clinical and Experimental
Y1  - 1994///
VL  - 43
IS  - 4
SP  - 481
EP  - 486
SN  - 0026-0495
AD  - Zurlo, F.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th St, Room 541, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19951409458.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - A low metabolic rate for a given body size and a low fat compared with carbohydrate oxidation ratio are known risk factors for body weight gain, but the underlying biological mechanisms are poorly understood. 24-h energy expenditure (24EE), sleeping metabolic rate (SMR), 24-h respiratory quotient (24RQ) and forearm oxygen uptake were compared with respect to the proportion of skeletal muscle fibre types and the enzyme activities of the vastus lateralis in subjects (7 men and 7 women, 30±6 years old, 79.1±17.3 kg, 22±7% body fat). The following enzymes were chosen to represent the major energy-generating pathways: lactate dehydrogenase (LDH) and phosphofructokinase (PFK) for glycolysis; citrate synthase (CS) and β-hydroxyacl-coenzyme A dehydrogenase (β-OAC) for oxidation; and creatine kinase (CK) and adenylokinase (AK) for high-energy phosphate metabolism. Forearm resting oxygen uptake adjusted for muscle size correlated positively with the proportion of fast-twitch muscle fibres (IIa: r = 0.55, P=0.04; IIb: r = 0.51, P=0.06) and inversely with the proportion of slow oxidative fibres (I: r = -0.77, P=0.001). 24EE and SMR adjusted for differences in fat-free mass, fat mass, sex and age correlated with PFK activity (r = 0.56, P=004 and r = 0.69, P=0.007, respectively). 24RQ correlated negatively with β-OAC activity (r = -0.75, P=0.002). The findings suggest that differences in muscle biochemistry account for part of the interindividual variability in muscle oxygen uptake and whole-body energy metabolism, ie, metabolic rate and substrate oxidation.
KW  - adults
KW  - body weight
KW  - energy metabolism
KW  - enzyme activity
KW  - nutrition physiology
KW  - respiratory quotient
KW  - skeletal muscle
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations.
AU  - Yanagihara, R.
JO  - Advances in Virus Research
JF  - Advances in Virus Research
Y1  - 1994///
VL  - 43
SP  - 147
EP  - 186
SN  - 0065-3527
AD  - Yanagihara, R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952009588.  Publication Type: Journal Article.  Language: English.  Number of References: 12 pages of refs.
KW  - epidemiology
KW  - genotypes
KW  - human diseases
KW  - markers
KW  - migration
KW  - reviews
KW  - viral diseases
KW  - Australasia
KW  - Melanesia
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Human T-cell lymphotropic virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Oceania
KW  - Australasia
KW  - Pacific Islands
KW  - HTLV-BLV group
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009588&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene arrangement and sequence of the 5S rRNA in Filobasidiella neoformans (Cryptococcus neoformans) as a phylogenetic indicator.
AU  - Kwon-Chung, K. J.
AU  - Chang, Y. C.
JO  - International Journal of Systematic Bacteriology
JF  - International Journal of Systematic Bacteriology
Y1  - 1994///
VL  - 44
IS  - 2
SP  - 209
EP  - 213
SN  - 0020-7713
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201096.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The 5S rRNA gene was cloned and its organization was determined in the 4 genes encoding rRNAs in a ribosomal DNA repeat unit of F. neoformans, the teleomorph of C. neoformans. The 5S rRNA gene contained 118 nucleotides and was located 1 kb upstream from the 18S rRNA gene within the 8.6 kb fragment of the ribosomal DNA repeat unit. The sequence of the 5S rRNA gene from F. neoformans was more similar to the sequence of the 5S rRNA gene from Tremella mesenterica than to sequences of the 5S rRNA genes from Filobasidium species. The arrangement of the rRNA genes in Filobasidiella neoformans closely resembled the arrangement of the rRNA genes in Schizophyllum commune, Agaricus bisporus and Coprinus cinereus in that the 5S rRNA-coding region not only is located within the repeat unit that encodes the other rRNAs but is also transcribed in the same direction as the other rRNA genes.
KW  - genes
KW  - genetics
KW  - nucleotide sequences
KW  - ribosomal RNA
KW  - Cryptococcus neoformans
KW  - Filobasidiella
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus (Fungi)
KW  - DNA sequences
KW  - Filobasidiella neoformans
KW  - fungus
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Host virus interactions and the molecular regulation of HIV-1: role in the pathogenesis of HIV-associated nephropathy.
AU  - Rappaport, J.
AU  - Kopp, J. B.
AU  - Klotman, P. E.
JO  - Kidney International
JF  - Kidney International
Y1  - 1994///
VL  - 46
IS  - 1
SP  - 16
EP  - 27
SN  - 0085-2538
AD  - Rappaport, J.: Building 30, Room 433, National Institute of Dental Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952009594.  Publication Type: Journal Article.  Language: English.  Number of References: 165 ref.
N2  - A review.
KW  - host range
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - kidney diseases
KW  - molecular biology
KW  - pathogenesis
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - kidney disorders
KW  - nephropathy
KW  - renal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009594&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice.
AU  - Ray, P. E.
AU  - Bruggeman, L. A.
AU  - Weeks, B. S.
AU  - Kopp, J. B.
AU  - Bryant, J. L.
AU  - Owens, J. W.
AU  - Notkins, A. L.
AU  - Klotman, P. E.
JO  - Kidney International
JF  - Kidney International
Y1  - 1994///
VL  - 46
IS  - 3
SP  - 759
EP  - 772
SN  - 0085-2538
AD  - Ray, P. E.: Building 30, Room 433, National Institute of Dental Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952009593.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref.
N2  - HIV-associated nephropathy is characterized by extensive tubulointerstitial disease with epithelial cell injury, microcystic proliferation, and tubular regeneration with glomerulosclerosis. To explore the role of bFGF as a mediator of HIV-induced interstitial disease, the authors utilized an HIV transgenic mouse model that manifests clinical and histological features observed in patients. In transgenic mice, simultaneous renal epithelial cell proliferation and injury were detected in vivo. In areas of microcystic proliferation, immunoreactive bFGF colocalized with extracellular matrix. Kidneys from transgenic mice had increased bFGF low affinity binding sites, particularly in the renal interstitium. In vitro, transgenic renal tubular epithelial cells proliferated more rapidly and generated tubular structures spontaneously, in marked contrast to nontransgenic renal cells where these pathological features could be mimicked by exogenous bFGF. These studies suggest that renal bFGF and its receptors play an important role in the pathogenesis of HIV-associated nephropathy.
KW  - animal experiments
KW  - genetically engineered organisms
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - kidney diseases
KW  - laboratory animals
KW  - receptors
KW  - transgenic animals
KW  - man
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - animal research
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GMOs
KW  - human immunodeficiency virus
KW  - kidney disorders
KW  - nephropathy
KW  - renal diseases
KW  - transgenic organisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009593&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of human herpesvirus-6 in paraffin-embedded tissue of cervical cancer by polymerase chain reaction.
AU  - Wang, H.
AU  - Chen, M.
AU  - Berneman, Z. N.
AU  - Delgado, G.
AU  - Paolo, J. A. di
JO  - Journal of Virological Methods
JF  - Journal of Virological Methods
Y1  - 1994///
VL  - 47
IS  - 3
SP  - 297
EP  - 305
SN  - 0166-0934
AD  - Wang, H.: Laboratory of Biology, Bldg 37/2A19, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952000954.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Public Health
N2  - The polymerase chain reaction (PCR) was used to detect human herpesvirus-6 (HHV-6) DNA sequences from paraffin-embedded tissue from cervical cancer patients in the USA. Two of 8 cases were positive for HHV-6 using 2 sets of HHV-6 primers. Hybridization of PCR products with specific radioisotope-labelled oligonucleotide probes confirmed the results. Furthermore, HHV-6 typing was possible by adapting restriction endonuclease digestion of PCR product. This method is useful for retrospective studies in investigating the aetiological role of HHV-6 in the development of human diseases.
KW  - cervical cancer
KW  - detection
KW  - human diseases
KW  - neoplasms
KW  - polymerase chain reaction
KW  - tissues
KW  - North America
KW  - USA
KW  - human herpesvirus 6
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - PCR
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000954&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Management of toxoplasmosis.
AU  - St Georgiev, V.
JO  - Drugs
JF  - Drugs
Y1  - 1994///
VL  - 48
IS  - 2
SP  - 179
EP  - 188
SN  - 0012-6667
AD  - St Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 4C-04, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950810167.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Subject Subsets: Protozoology
N2  - A review of the prenatal treatment of Toxoplasma gondii infections, and the treatment of T. gondii infections in newborn infants, is presented under the following subject headings: congenital toxoplasmosis (spiramycin-based therapy, pyrimethamine and sulphonamides) ; chemoprophylaxis in newborn infants; management of toxoplasmic retinochoroiditis; acquired (non- congenital) toxoplasmosis (management of toxoplasmic encephalitis, immunocompromised hosts, maintenance/prophylactic therapy); pulmonary toxoplasmosis; toxoplasmic myocarditis.
KW  - antiprotozoal agents
KW  - children
KW  - drug therapy
KW  - human diseases
KW  - immunocompromised hosts
KW  - parasites
KW  - reviews
KW  - toxoplasmosis
KW  - treatment
KW  - man
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - chemotherapy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biology of neurocysticercosis - parasite related factors modulating host response.
AU  - Shankar, S. K.
AU  - Suryanarayana, V.
AU  - Vasantha, S.
AU  - Ravi, V.
AU  - Ravi Kumar
JO  - Medical Journal Armed Forces India
JF  - Medical Journal Armed Forces India
Y1  - 1994///
VL  - 50
IS  - 2
SP  - 79
EP  - 88
SN  - 0377-1237
AD  - Shankar, S. K.: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India.
N1  - Accession Number: 19950809286.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Helminthology
N2  - In an immunohistochemical study, three features relating to the biology of Cysticercus cellulosae [Taenia solium] were identified. In an attempt at identifying which part of the parasite was recognized by the host immune system, it was found that the surface glycoprotein is immunolabelled by cerebrospinal fluid (CSF) in patients with neurocysticercosis. This surface protein is depleted following specific anthelmintic therapy, thus accounting for a fall in anticysticercal antibody levels in the CSF. The cysticercal cyst was found to have an "ACTH-like" molecule in the body wall, and neurotransmitter and mitochondrial metabolic pathways similar to the host, which facilitate immune evasion and successful parasitization. C. cellulosae was also found to contain a "peptide" opening the blood-brain barrier at the arteriolar level when injected intravenously into mice. In patients, a similar mechanism may result in cerebral oedema, particularly after treatment with praziquantel.
KW  - central nervous system
KW  - cerebrospinal fluid
KW  - cysticercosis
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunohistochemistry
KW  - metacestodes
KW  - nervous system diseases
KW  - parasites
KW  - peptides
KW  - man
KW  - Taenia solium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - CNS
KW  - immunity reactions
KW  - immunological reactions
KW  - neuropathy
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809286&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - DNA typing of rickettsiae in naturally infected ticks using a polymerase chain reaction/restriction fragment length polymorphism system.
AU  - Gage, K. L.
AU  - Schrumpf, M. E.
AU  - Karstens, R. H.
AU  - Burgdorfer, W.
AU  - Schwan, T. G.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1994///
VL  - 50
IS  - 2
SP  - 247
EP  - 260
SN  - 0002-9637
AD  - Gage, K. L.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19940503438.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology; Public Health
N2  - The polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) rickettsial typing system of R.L. Regenery and others was used to rapidly identify rickettsiae in naturally infected ticks. Unlike previously described methods, these PCR assays type rickettsiae directly from tick tissues without first isolating the organisms. 226 adult Dermacentor andersoni ticks were collected in the Bitterroot Mountains of western Montana, USA, and analysed for possible rickettsial infection by haemolymph test using the Gimenez stain. 13 (5.8%) of these ticks were positive by haemolymph test and selected for further analysis using the above PCR/RFLP typing system. The PCR assays performed using the first primer set (RpCS) resulted in amplification of fragments of the predicted size from 9 of the 13 haemolymph test-positive tick samples. Only 4 of these 9 tick samples were also positive in similar PCR assays performed with a second primer set (Rr190) that is presumed to be spotted fever group specific. The RFLP analyses of material amplified from these 4 ticks indicated they were infected with Rickettsia rickettsii (1 sample) and R. rhipicephali (3 samples). The PCR/RFLP analyses of the 5 PCR-positive ticks samples that were positive only in assays performed with the RpCS primer set indicated that these ticks were infected with R. bellii. The remaining 4 of 13 haemolymph test-positive tick samples gave negative PCR results with both the RpCS and Rr190 primer sets. Infected haemocytes from these PCR-negative ticks contained organisms of distinctive bacillary morphology that appeared similar to those described previously as long forms, and it is possible that these organisms belong to a genus other than Rickettsia. Established laboratory isolates of tick-borne rickettsiae from different regions of North America were also examined to determine whether this typing system produces consistent results. Multiple isolates of R. montana (9 isolates), R. bellii (5 isolates), R. rickettsii (Hlp-like) (4 isolates), and R. canada (2 isolates) were tested and no significant variations in PCR/RFLP patterns were observed between members of the same serotypes. However, among the 5 isolates of R. rhipicephali tested, 2 slightly different RFLP patterns were noted. The results suggest that this PCR/RFLP typing scheme has wide applicability for identifying rickettsiae directly from D. andersoni or D. variabilis tick tissues.
KW  - biotechnology
KW  - classification
KW  - diagnostic techniques
KW  - disease vectors
KW  - DNA
KW  - genotypes
KW  - identification
KW  - polymerase chain reaction
KW  - restriction fragment length polymorphism
KW  - species differences
KW  - Montana
KW  - North America
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Dermacentor andersoni
KW  - Dermacentor variabilis
KW  - Haemaphysalis leporispalustris
KW  - Ixodidae
KW  - Rickettsia
KW  - Rickettsia bellii
KW  - Rickettsia canadensis
KW  - Rickettsia montanensis
KW  - Rickettsia rhipicephali
KW  - Rickettsia rickettsii
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Dermacentor
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Haemaphysalis
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Rickettsia
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Mountain States of USA
KW  - Western States of USA
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - DNA typing
KW  - PCR
KW  - RFLP
KW  - Rickettsia canada
KW  - Rickettsia montana
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Natural history of Schistosoma mansoni infection in mice: egg production, egg passage in the feces, and contribution of host and parasite death to changes in worm numbers.
AU  - Cheever, A. W.
AU  - Mosimann, J. E.
AU  - Deb, S.
AU  - Cheever, E. A.
AU  - Duvall, R. H.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1994///
VL  - 50
IS  - 3
SP  - 269
EP  - 280
SN  - 0002-9637
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940805199.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Mice, C57BL/6N (B6) and BALB/cAnN (BALB), infected with Schistosoma mansoni were examined 8-26 weeks postinfection (pi) to estimate the fecundity of the worms and the contribution of death of worms and the death of heavily infected mice to the decrease in worm numbers in chronic infections. Portal worms were recovered by perfusion and the lungs were examined for parasites shunted from the portal circulation. Animals that died were more heavily infected than those that survived. Between 8 and 12 weeks pi, this loss of worms resulted in a net decrease of approximately 19% of worm pairs in surviving BALB mice, but of only 4% in B6 mice. Loss of portal worms to the lungs after the 8th week of infection was 9-13% of portal worms in BALB mice and 3-4% in B6 mice. The estimated rates of egg production by S. mansoni decreased slightly with time in both strains of mice. At 12 and 20 weeks pi, tissue eggs per worm pair and eggs passed in the faeces per worm pair often decreased as the intensity of infection increased. The loss of worms in the murine host is not considered to be relevant to most infections in humans because of the high intensity of infection relative to body size in mice and the high frequency of severe portal obstruction in murine infections.
KW  - developmental stages
KW  - fecundity
KW  - helminths
KW  - laboratory animals
KW  - ova
KW  - parasites
KW  - schistosomiasis
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - growth phase
KW  - parasitic worms
KW  - schistosomiasis mansoni
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetics of egg production and egg excretion by Schistosoma mansoni and S. japonicum in mice infected with a single pair of worms.
AU  - Cheever, A. W.
AU  - Macedonia, J. G.
AU  - Mosimann, J. E.
AU  - Cheever, E. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1994///
VL  - 50
IS  - 3
SP  - 281
EP  - 295
SN  - 0002-9637
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19940805200.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Individual male and female schistosomes approximately 3 weeks of age were implanted into the portal venous system of C57Bl/6 mice to produce infections with a single pair of Schistosoma mansoni or S. japonicum. Mice were killed between 7 and 54 weeks after infection. Worm fecundity was measured by counting eggs accumulating in the tissues and eggs passed in the faeces. Schistosoma mansoni worm pairs laid approximately 350 eggs per day with no change in the apparent rate of egg laying between 8 and 52 weeks after infection and approximately one third of the eggs were passed in the faeces. Schistosoma japonicum worm pairs laid approximately 2200 eggs per day initially and this decreased to 1000 eggs per day by the end of the experiment, with one-third to one-half of the eggs being passed in the faeces. There was marked variability in the fecundity of individual worm pairs, but the number of eggs passed in the faeces of individual mice correlated well with the number of eggs in the intestines at all time points in S. mansoni-infected mice and at the 7th and 10th week of S. japonicum infection.
KW  - developmental stages
KW  - fecundity
KW  - helminths
KW  - laboratory animals
KW  - ova
KW  - parasites
KW  - schistosomiasis
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma japonicum
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - growth phase
KW  - parasitic worms
KW  - schistosomiasis japonica
KW  - schistosomiasis mansoni
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Psychiatric evaluation of human immunodeficiency virus seropositives in Armed Forces.
AU  - Prabhu, H. R. A.
AU  - Arora, P. N.
AU  - Valdiya, P. S.
AU  - Chakraborty, P. K.
AU  - Rajguru, B. B.
JO  - Medical Journal Armed Forces India
JF  - Medical Journal Armed Forces India
Y1  - 1994///
VL  - 50
IS  - 4
SP  - 275
EP  - 278
SN  - 0377-1237
AD  - Prabhu, H. R. A.: National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India.
N1  - Accession Number: 19952004075.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref.
KW  - acquired immune deficiency syndrome
KW  - clinical aspects
KW  - HIV infections
KW  - military personnel
KW  - sexual transmission
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - clinical picture
KW  - human immunodeficiency virus infections
KW  - psychiatric conditions
KW  - venereal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Murine retroviral vector that induces long-term expression of HIV-1 envelope protein.
AU  - Fujita, K.
AU  - Maldarelli, F.
AU  - Purcell, D. F. J.
AU  - Silver, J.
JO  - Journal of Virological Methods
JF  - Journal of Virological Methods
Y1  - 1994///
VL  - 50
IS  - 1/3
SP  - 293
EP  - 312
SN  - 0166-0934
AD  - Fujita, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 338, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002346.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
KW  - envelope proteins
KW  - gene expression
KW  - Rev protein
KW  - vectors
KW  - Vpu protein
KW  - Human immunodeficiency virus 1
KW  - Retroviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002346&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin A in epithelial differentiation and skin carcinogenesis.
AU  - Luca, L. M. de
AU  - Darwiche, N.
AU  - Celli, G.
AU  - Kosa, K.
AU  - Jones, C.
AU  - Ross, S.
AU  - Chen, L. C.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1994///
VL  - 52
IS  - 2
SP  - s45
EP  - s52
SN  - 0029-6643
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951400217.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - The role of vitamin A in epithelial differentiation and skin carcinogenesis is reviewed.
KW  - carcinogenesis
KW  - cell differentiation
KW  - retinol
KW  - reviews
KW  - skin
KW  - vitamins
KW  - axerophthol
KW  - cytodifferentiation
KW  - dermis
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400217&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stimulation of pS2 expression by diet-derived compounds.
AU  - Sathyamoorthy, N.
AU  - Wang, T. T. Y.
AU  - Phang, J. M.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1994///
VL  - 54
IS  - 4
SP  - 957
EP  - 961
SN  - 0008-5472
AD  - Sathyamoorthy, N.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute, Frederick Cancer Research and Development Center, NIH, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19951405140.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Horticultural Science; Human Nutrition; Aromatic & Medicinal Plants
N2  - Epidemiological studies suggest a lowered risk of hormone-dependent cancers among vegetarians, but the basis for this association remains unclear. Vegetables and fruits contain certain compounds which can be converted to biologically active hormone-like substances, such as lignans and isoflavones, by intestinal flora. The interaction of these compounds with endogenous hormones may be a novel, diet-dependent mechanism in cancer prevention. To explore this possibility, a rapid, specific assay system was developed to screen for compounds with oestrogen-like activity in tissue culture. The oestrogen receptor-positive breast cancer cell MCF-7 was used and the expression of the oestrogen-responsive protein pS2 was monitored by Northern blots. Results indicated that the phenolic compounds daidzein, equol, nordihydroguaiaretic acid, enterolactone and kaempferol were able to elicit an oestrogen-like response, while quercetin and enterodiol were not.
KW  - analytical methods
KW  - anticarcinogenic properties
KW  - carcinogenesis
KW  - cell cultures
KW  - flavonoids
KW  - flavonols
KW  - isoflavonoids
KW  - lignans
KW  - medicinal plants
KW  - oestrogenic properties
KW  - pharmacology
KW  - phenolic compounds
KW  - plant oestrogens
KW  - plants
KW  - eukaryotes
KW  - analytical techniques
KW  - anti-carcinogenic properties
KW  - drug plants
KW  - estrogenic properties
KW  - medicinal herbs
KW  - officinal plants
KW  - phytoestrogens
KW  - plant estrogens
KW  - Techniques and Methodology (ZZ900) 
KW  - Other Produce (QQ070) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - 1α,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat.
AU  - Anzano, M. A.
AU  - Smith, J. M.
AU  - Uskokovic´, M. R.
AU  - Peer, C. W.
AU  - Mullen, L. T.
AU  - Letterio, J. J.
AU  - Welsh, M. C.
AU  - Shrader, M. W.
AU  - Logsdon, D. L.
AU  - Driver, C. L.
AU  - Brown, C. C.
AU  - Roberts, A. B.
AU  - Sporn, M. B.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1994///
VL  - 54
IS  - 7
SP  - 1653
EP  - 1656
SN  - 0008-5472
AD  - Anzano, M. A.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951406207.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 1406-16-2.  Subject Subsets: Human Nutrition
N2  - The vitamin D analogue, 1α,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) was used for inhibition of mammary carcinogenesis induced by N-nitroso-N-methylurea (NMU) in Sprague-Dawley rats. Rats were first treated with a single dose of 15 or 50 mg/kg body weight NMU and then fed Ro24-5531 (2.5 or 1.25 nmol/kg diet) for 5-7 months. Ro24-5531 significantly extended tumour latency and lessened tumour incidence as well as tumour number in rats treated with the lower dose of NMU. In rats treated with the higher dose of NMU, Ro24-5531 was fed in combination with tamoxifen; in these experiments, Ro24-5531 significantly enhanced the ability of tamoxifen to reduce total tumour burden, as well as to increase the probability that a rat would be tumour free at the end of the experiment. In vitro, Ro24-5531 was 10 to 100 times more potent than 1,25-dihydroxyvitamin D3 for inhibition of proliferation of human breast cancer cell lines as well as primary cultures of cells from 2 patients with acute myelogenous leukemia. When fed chronically, Ro24-5531 did not elevate serum calcium in the present studies. The new term, "deltanoids" is proposed for the set of molecules composed of vitamin D and its synthetic analogues, in a manner similar to the naming of "retinoids" for the corresponding set of molecules related to vitamin A.
KW  - analogues
KW  - cell cultures
KW  - intake
KW  - mammary gland neoplasms
KW  - vitamin D
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - mammary tumour
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of N-(4-hydroxyphenyl)retinamide supplementation on vitamin A metabolism.
AU  - Lewis, K. C.
AU  - Zech, L. A.
AU  - Phang, J. M.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1994///
VL  - 54
IS  - 15
SP  - 4112
EP  - 4117
SN  - 0008-5472
AD  - Lewis, K. C.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19951407332.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - The efficacy of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been demonstrated in the inhibition of cancers in a variety of tissues. Moreover, toxicity effects following administration of 4-HPR have been found to be reduced or absent when compared to other retinoids. Pharmacokinetic studies in both animals and man have focused on the metabolism of 4-HPR and its metabolites, and relatively little information has been published detailing the effects of long-term administration of 4-HPR upon normal endogenous vitamin A metabolism. Thus, this study examined the effects of long-term administration of 4-HPR upon plasma and tissue vitamin A kinetics. Male Sprague-Dawley rats were fed on a control diet sufficient in vitamin A (CON group; 1.0 retinol (ROH) equivalents/g diet) or a CON diet supplemented with 4-HPR (CON + 4HPR group; 4-HPR 1173 µg/g diet). Following i.v. injection of a physiologically radiolabelled dose of ROH, ROH tracer and tracee kinetics were monitored in plasma and tissues over a 41-day period. Kinetic parameters were estimated using the SAAM/CONSAM computer modelling programmes to carry out graphical analysis of the tracer concentration curves. Mean plasma ROH levels estimated for the CON + 4HPR group were reduced to one-third of those of the CON group. Most of the kinetic parameters calculated were found to be significantly altered by the inclusion of 4-HPR in the diet. The fraction of the plasma ROH being catabolized per day (fractional catabolic rate) was nearly twice as high in the CON + 4HPR treated group (3.61±0.49) as compared to the CON group (2.00±0.68 day-1). The amount of time that vitamin A molecules spent in the body before being lost irreversibly from the system (system residence time) was decreased by half in the CON + 4HPR group (19.20±7.13 days) versus the CON group (38.63±9.62 days). Despite the increased catabolic rates and decreased system residence times estimated for the CON + 4HPR group, the estimated vitamin A use in these rats (11.01±3.10 µg/day) was 33% less than that used by the CON group (16.31±2.47 µg/day). Results suggest that long-term administration of 4-HPR perturbs normal vitamin A metabolism in rats.
KW  - metabolism
KW  - retinoids
KW  - retinol
KW  - vitamins
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A compounds
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407332&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen.
AU  - Anzano, M. A.
AU  - Byers, S. W.
AU  - Smith, J. M.
AU  - Peer, C. W.
AU  - Mullen, L. T.
AU  - Brown, C. C.
AU  - Roberts, A. B.
AU  - Sporn, M. B.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1994///
VL  - 54
IS  - 17
SP  - 4616
EP  - 4617
SN  - 0008-5472
AD  - Anzano, M. A.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951407405.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - It was shown that 9-cis-retinoic acid (9cRA) is a potent inhibitor of mammary carcinogenesis induced by N-nitroso-N-methylurea in Sprague-Dawley rats. Rats were first treated with a single dose of N-nitroso-N-methylurea (50 mg/kg body weight) and then fed on non-toxic levels of 9cRA (120 or 60 mg/kg of diet). 9cRA was highly effective in reducing tumour incidence, average number of tumours per rat and average tumour burden, as well as extending tumour latency. The combination of 9cRA with low levels of tamoxifen (TAM; fed at 1.0 or 0.5 mg/kg of diet) was particularly effective; addition of 9cRA to a TAM regimen doubled the number of rats that were tumour-free at autopsy and significantly diminished tumour number and tumour burden. For suppression of carcinogenesis in vivo, 9cRA was much more potent than all-trans-retinoic acid, both as a single agent or in combination with TAM, although both retinoids had equivalent inhibitory effects on DNA synthesis in cultured human breast cancer cell lines. Both 9cRA and all-trans-retinoic acid induce the expression of the adhesion molecule, E-cadherin, in the SK-BR-3 cell line. It is suggested that clinical evaluation of the combination of 9cRA and TAM, for chemoprevention or for adjuvant therapy, should be considered.
KW  - carcinoma
KW  - drug therapy
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - prevention
KW  - retinoic acid
KW  - vitamins
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - chemotherapy
KW  - mammary tumour
KW  - tretinoin
KW  - vitamin A acid
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The E1A oncogene induces resistance to the effects of 1,25-dihydroxyvitamin D3 on inhibition of growth of mouse keratinocytes.
AU  - Park, K.
AU  - Bae, H.
AU  - Heydemann, A.
AU  - Roberts, A. B.
AU  - Dotto, G. P.
AU  - Sporn, M. B.
AU  - Kim, S. J.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1994///
VL  - 54
IS  - 23
SP  - 6087
EP  - 6089
SN  - 0008-5472
AD  - Park, K.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951408501.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 32222-06-3.  Subject Subsets: Human Nutrition
N2  - Calcitriol inhibited DNA synthesis in transformed mouse keratinocytes (Pam212) in a time- and dose-dependent manner as measured by [³H]thymidine incorporation. To investigate the mechanism through which calcitriol acts, its effects on Pam212 cells further transformed with the E1A oncogene were examined. It is shown that transformation of the cells with the E1A oncogene induced resistance to the effects of calcitriol on inhibition of growth of Pam212 cells. While calcitriol treatment increased the level of expression of vitamin D receptor mRNA 20-fold in parental cells, the E1A-transformed cells failed to express vitamin D receptor mRNA even after treatment with calcitriol. Transfection of the E1A-transformed cell line with an expression construct encoding the vitamin D receptor restored receptor expression as well as the inhibition of growth by calcitriol. These results suggest that one of the mechanisms for acquisition of calcitriol resistance induced by E1A may involve loss of vitamin D receptor inducibility by calcitriol.
KW  - calcitriol
KW  - carcinogenesis
KW  - cell cultures
KW  - oncogenes
KW  - vitamins
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 1,25-dihydroxycholecalciferol
KW  - 1,25-dihydroxyvitamin D
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408501&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans.
AU  - Sinha, R.
AU  - Rothman, N.
AU  - Brown, E. D.
AU  - Mark, S. D.
AU  - Hoover, R. N.
AU  - Caporaso, N. E.
AU  - Levander, O. A.
AU  - Knize, M. G.
AU  - Lang, N. P.
AU  - Kadlubar, F. F.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1994///
VL  - 54
IS  - 23
SP  - 6154
EP  - 6159
SN  - 0008-5472
AD  - Sinha, R.: Environmental Epidemiology, Branch/Epidemiology, National Cancer Institute, N1H, Rockville, Maryland 20892, USA.
N1  - Accession Number: 19951408504.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Human Nutrition
N2  - Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) activities were examined in healthy nonsmokers (33 men and 33 women). The study was designed to minimize the influence of known inducers of CYP1A2. Subjects consumed meat pan-fried at a low temperature (100°C) for 7 days followed by 7 days of meat pan-fried at a high temperature (250°C). The low temperature-cooked meat had undetectable levels of heterocyclic amines (HAAs) while the high temperature-cooked meat contained high amounts of HAAs (2-amino-3,8-dimethylimidazo(4.5-f)quinoxaline (MeIQx) 9.0 ng/g, 2-amino-3,7,8-trimethylimidazo(4.5-f)quinoxaline (DiMeIQx) 2.1 ng/g and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) 32.8 ng/g). In contrast, total polycyclic aromatic hydrocarbon content was similar in both meat samples (10.7 ng/g in low temperature-cooked meat and 10.1 ng/g in high temperature-cooked meat). At the end of each period, subjects wee tested for CYP1A2 and NAT2 enzyme activity by caffeine metabolism phenotyping. NAT2 activity remained unchanged throughout the study while CYP1A2 activity increased in 72% of subjects after consuming high temperature-cooked meat (P&lt;0.0002), suggesting induction by some compound(s) formed during high temperature cooking. If HAAs are shown to be human carcinogens in epidemiological studies, then meat cooked at high temperatures may pose an increased cancer risk because it contains both inducers of CYP1A2 and procarcinogens Me1Qx, DiMeIQx, and PhIP known to be activated by this enzyme.
KW  - carcinogenesis
KW  - carcinogens
KW  - cytochromes
KW  - frying
KW  - heterocyclic nitrogen compounds
KW  - meat
KW  - risk
KW  - temperature
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Meat Produce (QQ030) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of ethnic differences on the pattern of HTLV-I-associated T-cell leukemia/lymphoma (HATL) in the United States.
AU  - Levine, P. H.
AU  - Manns, A.
AU  - Jaffe, E. S.
AU  - Colclough, G.
AU  - Cavallaro, A.
AU  - Reddy, G.
AU  - Blattner, W. A.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1994///
VL  - 56
IS  - 2
SP  - 177
EP  - 181
SN  - 0020-7136
AD  - Levine, P. H.: National Cancer Institute, EPN #434, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005637.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Public Health
N2  - Although human T-cell lymphotropic virus type I (HTLV-I) is endemic in Japan and the Caribbean islands, the reported clinical and epidemiological features of adult T-cell leukaemia/lymphoma (ATL) in these 2 parts of the world are quite different. ATL has been diagnosed at a younger age and is reported more frequently as the lymphomatous type rather than the acute type with leukaemia in the Caribbean basin as compared with the presentation in Japan. In order to characterize ATL in the USA, a registry has been established at the National Cancer Institute for the purpose of recording all cases originally diagnosed in the USA. This registry was utilized to examine the effect of ethnic differences on age of onset and clinical features of ATL, using the same database. Clinical and laboratory information was obtained from 177 patients suspected of having ATL, who were treated at the National Institutes of Health, or had biological samples sent for evaluation, or were reported in the literature. Histopathological review and virological studies were performed by standardized methods. Of 177 patients registered, 127 were considered as having ATL, according to an algorithm combining clinical, pathological and laboratory features. Presenting features in the confirmed cases consisted primarily of lymphadenopathy (76.6%), hypercalcaemia (72.5%), leukaemia (82%), skin involvement (48.2%) and hepatomegaly (53.6%). Patients of Japanese ancestry were generally older (median age 63, range 51 to 73 years) than patients of African-American descent (median age 39, range 7 to 75 years) and presented more often with leukaemia (90% vs. 69%). Of the 103 cases where country of birth was confirmed, 45 (43.7%) were born in the USA. The prognosis was generally poor (median survival 3.24 months), but rare long-term remissions were documented.
KW  - adult t-cell leukaemia
KW  - disease prevalence
KW  - ethnicity
KW  - HTLV infections
KW  - human diseases
KW  - infections
KW  - leukaemia
KW  - neoplasms
KW  - North America
KW  - USA
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - adult T-cell leukemia
KW  - blood cancer
KW  - cancers
KW  - ethnic differences
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - leucaemia
KW  - leukemia
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Koumbalones A and B, new casbane diterpenes from Maprounea africana.
AU  - Kashman, Y.
AU  - Bernart, M. W.
AU  - Tischler, M.
AU  - Cardellina II, J. H.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1994///
VL  - 57
IS  - 3
SP  - 426
EP  - 430
SN  - 0163-3864
AD  - Kashman, Y.: Laboratory of Drug Discovery Research & Development, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702, USA.
N1  - Accession Number: 19950301194.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Horticultural Science
N2  - The organic extract of Maprounea africana roots (collected from the Central African Republic) yielded koumbalones A and B, defined by spectral methods as new variations on the casbane ring system. Their structures, relative configurations, and solution conformations were determined by a combination of spectral analyses and molecular modeling. Because koumbalone A spontaneously converts to koumbalone B at room temperature, koumblane B may be an artefact of isolation.
KW  - chemical structure
KW  - diterpenoids
KW  - medicinal plants
KW  - plant composition
KW  - roots
KW  - spectral analysis
KW  - Central African Republic
KW  - Euphorbiaceae
KW  - Euphorbiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Euphorbiaceae
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - chemical constituents of plants
KW  - drug plants
KW  - Maprounea
KW  - Maprounea africana
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950301194&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cucurbitacins: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii.
AU  - Fuller, R. W.
AU  - Cardellina, J. H., II
AU  - Cragg, G. M.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1994///
VL  - 57
IS  - 10
SP  - 1442
EP  - 1445
SN  - 0163-3864
AD  - Fuller, R. W.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19950300282.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - A characteristic pattern of differential cytotoxicity of extracts of Iberis amara seeds, predominantly toward renal tumour, brain tumour and melanoma cell lines in the NCI human disease-oriented tumour screening panel, was traced to cucurbitacins E and I. This same differential cytotoxicity profile was detected in extracts of Begonia plebeja roots (collected from Belize) and Gonystylus keithii twigs (collected from Sarawak). Computer-assisted recognition of these profiles was followed by a rapid chemical fractionation, thus permitting the efficient dereplication of those extracts containing cucurbitacins B and D, respectively. This is the first report of cucurbitacins from the genus Gonystylus.
KW  - cell lines
KW  - cucurbitacins
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - isolation
KW  - plant composition
KW  - plant extracts
KW  - roots
KW  - seeds
KW  - stems
KW  - sterols
KW  - triterpenoids
KW  - Belize
KW  - Sarawak
KW  - Begonia
KW  - Begoniaceae
KW  - Brassicaceae
KW  - Gonystylus
KW  - Iberis
KW  - man
KW  - Thymelaeaceae
KW  - Begoniaceae
KW  - Violales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Capparidales
KW  - Thymelaeaceae
KW  - Myrtales
KW  - Brassicaceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Begonia
KW  - Gonystylus
KW  - Iberis
KW  - ACP Countries
KW  - Caribbean Community
KW  - Central America
KW  - America
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Borneo
KW  - South East Asia
KW  - Asia
KW  - Malaysia
KW  - APEC countries
KW  - ASEAN Countries
KW  - Threshold Countries
KW  - Begonia plebeja
KW  - Capparales
KW  - chemical constituents of plants
KW  - Gonystylus keithii
KW  - Iberis amara
KW  - Thymelaeales
KW  - Plant Composition (FF040) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Non-wood Forest Products (KK540) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950300282&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Novel naphthoquinones from Conospermum incurvum.
AU  - Dai, J. R.
AU  - Decosterd, L. A.
AU  - Gustafson, K. R.
AU  - Cardellina, J. H., II
AU  - Gray, G. N.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1994///
VL  - 57
IS  - 11
SP  - 1511
EP  - 1516
SN  - 0163-3864
AD  - Dai, J. R.: Laboratory of Drug Discovery Research and Developmental, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19950302631.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Registry Number: 130-15-4.  Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - During the re-isolation of the trimeric naphthoquinone derivative, conocurvone, from an extract of the roots of the Australian shrub, C. incurvum, 6 monomeric naphthoquinones were isolated (including 3 novel 1,4-naphthoquinone derivatives). The structures of the novel compounds were elucidated from spectral data. While conocurvone is a potent inhibitor of HIV-1-induced cell killing, all of the monomeric naphthoquinone derivatives were inactive against HIV-1.
KW  - chemical structure
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - naphthoquinones
KW  - plant composition
KW  - roots
KW  - spectral analysis
KW  - Australia
KW  - Proteaceae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Proteales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - chemical constituents of plants
KW  - Conospermum incurvum
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950302631&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Thoracotomy for pulmonary mycoses in non-HIV-immunosuppressed patients.
AU  - Temeck, B. K.
AU  - Venzon, D. J.
AU  - Moskaluk, C. A.
AU  - Pass, H. I.
JO  - Annals of Thoracic Surgery
JF  - Annals of Thoracic Surgery
Y1  - 1994///
VL  - 58
IS  - 2
SP  - 333
EP  - 338
SN  - 0003-4975
AD  - Temeck, B. K.: Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200293.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Of 36 immunosuppressed patients (28 men, 8 women, aged 4-59 yr) undergoing thoracotomy for the treatment of pulmonary fungal disease at the National Cancer Institute, Maryland, USA, during 1975-1993, the underlying causes of immunosuppression were malignancy (9 cases), Wegener's granulomatosis (4), haematological disorders (6) or chronic granulomatous disease of childhood (17). Symptoms present in 89% of patients included fever (27 cases), cough (20) and chest pain (14). Chest X-ray studies revealed the presence of cavitary disease in 7 patients, a mass in 8, infiltrates in 20 or cavity and infiltrate in 1. A preoperative diagnosis was lacking in 23 of the 36 patients. Procedures included wedge biopsy (13 cases), segmentectomy with or without wedge or chest wall resection (5), lobectomy with or without chest wall resection (16), wedge resection plus completion pneumonectomy (1) and segmentectomy plus completion pneumonectomy (1). Fungi identified included Aspergillus (23 cases), Zygomycetes (4), Cryptococcus neoformans (3) and Candida albicans, Coccidioides immitis, Conidiobolus incongruus, Histoplasma capsulatum, Sarcinosporon inkin and Wangiella dermatitidis in 1 patient each. Specific antifungal treatment was instituted in 34 patients (94%). Nine of 11 patients died of multiorgan system failure. Univariate analysis identified the following as prognostic of death during hospitalization: underlying haematological disease (P=0.012), angioinvasive disease (P=0.0064), treatment with chemotherapy and steroids (P=0.052), and a granulocyte percentage of ≤30% or a granulocyte count of ≤100 (P=0.048). Multivariate analysis revealed that angioinvasion correlated with all risk factors and operative mortality. 19 patients remained alive at a mean follow-up period of 2.8 yr.
KW  - aspergillosis
KW  - candidosis
KW  - coccidioidomycosis
KW  - cryptococcosis
KW  - histoplasmosis
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunosuppression
KW  - infections
KW  - lungs
KW  - opportunistic infections
KW  - predisposition
KW  - surgery
KW  - therapy
KW  - zygomycosis
KW  - Maryland
KW  - USA
KW  - Ancylistaceae
KW  - Aspergillus
KW  - Candida albicans
KW  - Coccidioides immitis
KW  - Conidiobolus
KW  - Cryptococcus neoformans
KW  - Deuteromycotina
KW  - Entomophthoraceae
KW  - Exophiala dermatitidis
KW  - Histoplasma capsulatum
KW  - man
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Coccidioides
KW  - Onygenaceae
KW  - Ancylistaceae
KW  - Entomophthorales
KW  - Entomophthoromycotina
KW  - Zygomycota
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Herpotrichiellaceae
KW  - Chaetothyriales
KW  - Conidiobolus
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Exophiala
KW  - Ajellomyces capsulatus
KW  - candidiasis
KW  - coccidiomycosis
KW  - Conidiobolus incongruus
KW  - european blastomycosis
KW  - fungus
KW  - Hyphomycetes
KW  - mitosporic fungi
KW  - phycomycosis
KW  - Sarcinosporon
KW  - Sarcinosporon inkin
KW  - therapeutics
KW  - United States of America
KW  - Wangiella
KW  - Wangiella dermatitidis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200293&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adult T-cell leukemia/lymphoma: a working point-score classification for epidemiological studies.
AU  - Levine, P. H.
AU  - Cleghorn, F.
AU  - Manns, A.
AU  - Jaffe, E. S.
AU  - Navarro-Roman, L.
AU  - Blattner, W. A.
AU  - Hanchard, B.
AU  - Oliveira, M. S. de
AU  - Matutes, E.
AU  - Catovsky, D.
AU  - Shimoyama, M.
AU  - Tajima, K.
AU  - Sonoda, S.
AU  - Yamaguchi, K.
AU  - Takatsuki, K.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1994///
VL  - 59
IS  - 4
SP  - 491
EP  - 493
SN  - 0020-7136
AD  - Levine, P. H.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010093.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
N2  - This report summarises current information regarding adult T-cell leukaemia/lymphoma (ATL) and proposes a classification facilitating comparison of case series in geographically and ethnically different populations.
KW  - human diseases
KW  - lymphoma
KW  - neoplasms
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010093&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Determinants of total daily energy expenditure: variability in physical activity.
AU  - Rising, R.
AU  - Harper, I. T.
AU  - Fontvielle, A. M.
AU  - Ferraro, R. T.
AU  - Spraul, M.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994///
VL  - 59
IS  - 4
SP  - 800
EP  - 804
SN  - 0002-9165
AD  - Rising, R.: National Institutes of Health, Clinical Diabetes and Nutrition Section, 4212 North 16th Street, Room 541-A, Phoenix, AZ 85016. USA.
N1  - Accession Number: 19941406887.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Human Nutrition
N2  - Excessive energy intake and/or reduced total daily energy expenditure (TEE) causes obesity. To examine the relation between obesity and TEE in an obesity-prone population, TEE, 24-h sedentary energy expenditure (SEDEE) and basal metabolic rate (BMR) were measured in 30 US Pima Indian men by the doubly labelled water method and a respiratory chamber. The energy expenditure for physical activity (EEACT) was calculated as TEE - (BMR + 0.1 TEE), where 10% of TEE is an estimate of the thermic effect of food. Fat-free mass was the best single determinant of TEE, explaining 48% of its variance. TEE, SEDEE, BMR and EEACT were 12010±2292, 9945±1559, 7677±1901 and 3297±1732 kJ/day, respectively. Because EEACT is dependent on body weight, EEACT/kg body weight and TEE/(BMR + 0.1 TEE) were used as indexes of the level of physical activity. Both indexes correlated negatively with percent body fat. The results suggest that obesity is associated with lower levels of physical activity.
KW  - energy exchange
KW  - ethnic groups
KW  - men
KW  - obesity
KW  - physical activity
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406887&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased risk of colorectal cancer among smokers: results of a 26-year follow-up of US veterans and a review.
AU  - Heineman, E. F.
AU  - Zahm, S. H.
AU  - McLaughlin, J. K.
AU  - Vaught, J. B.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1994///
VL  - 59
IS  - 6
SP  - 728
EP  - 738
SN  - 0020-7136
AD  - Heineman, E. F.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19962001394.  Publication Type: Journal Article.  Language: English.  Number of References: 72 ref. Subject Subsets: Public Health
N2  - A cohort of 248 046 American veterans (followed prospectively for 26 years) was evaluated to clarify the relationship between tobacco use and risk of colorectal cancer. In comparison with veterans who had never used tobacco, the risk of death was significantly increased for colon cancer and rectal cancer among current and former cigarette smokers and among pipe or cigar smokers, controlling for social class and occupational physical activity. Users of chewing tobacco or snuff also showed a significantly elevated rectal-cancer risk. For both sites, risk increased significantly with pack-years, earlier age at first use, and number of cigarettes. These results reinforce 2 recent reports of the association of cigarette smoking and colorectal cancer in men and women. Inconsistencies in the findings of earlier epidemiological studies appear to be due in large part to differences in length of follow-up or in choice of controls. Studies with at least 20 years of follow-up or population-based controls have tended to find elevated risk with tobacco smoking, while those with shorter follow-up or hospital controls have not. This, plus the strength and consistency of the association of smoking and colon polyps, suggest that smoking may primarily affect an early stage in the development of colon cancer. If this association is causal, tobacco use may be responsible for 16% of colon-cancer and 22% of rectal-cancer deaths among these veterans.
KW  - colon
KW  - colorectal cancer
KW  - epidemiology
KW  - human diseases
KW  - neoplasms
KW  - rectum
KW  - risk factors
KW  - tobacco smoking
KW  - toxicology
KW  - veterans
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - war veterans
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy intake and physical activity in relation to indexes of body fat: the National Heart, Lung, and Blood Institute Growth and Health Study.
AU  - Obarzanek, E.
AU  - Schreiber, G. B.
AU  - Crawford, P. B.
AU  - Goldman, S. R.
AU  - Barrier, P. M.
AU  - Frederick, M. M.
AU  - Lakaos, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994///
VL  - 60
IS  - 1
SP  - 15
EP  - 22
SN  - 0002-9165
AD  - Obarzanek, E.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941408052.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - The relation between energy intake, physical activity, and body fat was investigated in the baseline visit of 2379 black and white US girls 9-10 years old. 3-day food records, 3-day physical activity diaries, physical-activity pattern questionnaires, and an assessment of the length of time spent watching television and videos were obtained. Multivariate-regression analyses showed that age, number of hours of television and video watching, percent of energy from saturated fatty acids, and activity-pattern score best explained the variation in body mass index and sum of 3 skinfold-thickness measurements for black girls. The best model for white girls included age, number of hours of television and video watching, and percent of energy from total fat. The results indicate that body fatness is related to energy intake and expenditure in black and white girls. Longitudinal studies will help assess the value of these variables in predicting changes in body fat.
KW  - body fat
KW  - children
KW  - diet studies
KW  - energy intake
KW  - ethnic groups
KW  - girls
KW  - nutrition surveys
KW  - obesity
KW  - physical activity
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - nutritional surveys
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408052&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition database.
AU  - Yong, L. C.
AU  - Forman, M. R.
AU  - Beecher, G. R.
AU  - Graubard, B. I.
AU  - Campbell, W.
AU  - Reichman, M. E.
AU  - Taylor, P. R.
AU  - Lanza, E.
AU  - Holden, J.
AU  - Judd, J. T.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994///
VL  - 60
IS  - 2
SP  - 223
EP  - 230
SN  - 0002-9165
AD  - Yong, L. C.: Cancer Prevention Studies Branch, DCPC, National Cancer Institute, EPN-211, Rockville, MD 20892, USA.
N1  - Accession Number: 19941409972.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - The diet-plasma relations for carotenoids were examined in a group of 98 nonsmoking premenopausal women who participated in the cross-sectional phase of the National Cancer Institute (NCI)-US Department of Agriculture (USDA) diet study on alcohol-hormone metabolism, l988-90. With use of the newly developed USDA-NCI carotenoid food composition database, the mean daily intakes of carotenoids were significantly higher when estimated from the food-frequency questionnaire (FFQ) than from the 7-day diet records. Lycopene, lutein plus zeaxanthin, and β-carotene were the major plasma carotenoids. After adjustment for body mass index, energy and alcohol intakes, and total plasma cholesterol concentration, significant correlations were observed between the diet record and the FFQ-estimated carotenoid intakes and their respective plasma concentrations. The data indicated that plasma carotenoid concentrations were reflective of the dietary intake, but the magnitude of the correlation varied depending on the specific carotenoid and on the dietary assessment tool.
KW  - blood
KW  - carotenoids
KW  - databases
KW  - diet studies
KW  - food composition
KW  - intake
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - data banks
KW  - tetraterpenoids
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resting metabolic rate of anorexia nervosa patients during weight gain.
AU  - Obarzanek, E.
AU  - Lesem, M. D.
AU  - Jimerson, D. C.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994///
VL  - 60
IS  - 5
SP  - 666
EP  - 675
SN  - 0002-9165
AD  - Obarzanek, E.: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA.
N1  - Accession Number: 19951402478.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref. Subject Subsets: Human Nutrition
N2  - To examine whether changes in energy metabolism may contribute to the difficulty of weight gain observed in anorexic patients, resting metabolic rate (RMR) and neuroendocrine function were studied in 10 patients diagnosed with anorexia nervosa. RMR per kilogram lean body mass was not significantly different from that of healthy subjects on admission (95.9±5.6 vs. 103.6±3.3 kJ/kg, respectively), during early refeeding (108.6±6.9 kJ/kg), or at target weight (102.1±3.8 kJ/kg). At late refeeding, RMR was significantly higher (132.1±4.9 kJ/kg, P&lt;0.0001). There were no significant correlations between plasma norepinephrine and thyroid hormones and RMR. The increase in RMR during refeeding is at least double that observed in other studies in which normal-weight subjects are experimentally overfed or experimentally underfed and then refed. The results suggest that the increase in RMR during refeeding is disproportionate to weight gain and this large magnitude of increase may be unique to anorexia nervosa.
KW  - anorexia nervosa
KW  - energy metabolism
KW  - heat production
KW  - patients
KW  - refeeding
KW  - resting energy exchange
KW  - weight gain
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorigenesis
KW  - thermogenesis
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402478&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Eating behavior in bulimia nervosa: multiple meal analyses.
AU  - Hetherington, M. M.
AU  - Altemus, M.
AU  - Nelson, M. L.
AU  - Bernat, A. S.
AU  - Gold, P. W.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994///
VL  - 60
IS  - 6
SP  - 864
EP  - 873
SN  - 0002-9165
AD  - Hetherington, M. M.: Clinical Neuroendocrinology Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA.
N1  - Accession Number: 19951402517.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - 10 bulimic individuals were admitted to an inpatient unit and for 7 consecutive days eating behaviour was observed and recorded. Age-, sex- and weight-matched control subjects (n = 10) were admitted to the same unit for 4 days. All food and fluid intake, frequency of binge eating and purging, and ratings of appetite and mood before and after eating were recorded every 24 h. Bulimic patients demonstrated chaotic eating patterns that varied within as well as between individuals. Total daily energy intake was significantly higher for bulimic patients than for control subjects. On average, patients binged 1.6 times, purged 3 times and ate one snack or meal without purging daily. Macronutrient analyses of intake revealed significantly less energy from protein and more energy from fat in bulimic patients compared with control subjects. Some improvement of mood was noted after binges, the magnitude of which was greatest after purging.
KW  - analysis
KW  - appetite
KW  - appetite disorders
KW  - behaviour
KW  - bulimia
KW  - feeding behaviour
KW  - meals
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - behavior
KW  - binge eating
KW  - bulimia nervosa
KW  - eating disorders
KW  - feeding behavior
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402517&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Construction of a series of congenic mice with recombinant chromosome 1 regions surrounding the genetic loci for resistance to intracellular parasites (Ity, Lsh, and Bcg), DNA repair responses (Rep-1), and the cytoskeletal protein villin (Vil).
AU  - Mock, B. A.
AU  - Holiday, D. L.
AU  - Cerretti, D. P.
AU  - Darnell, S. C.
AU  - O'Brien, A. D.
AU  - Potter, M.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1994///
VL  - 62
IS  - 1
SP  - 325
EP  - 328
SN  - 0019-9567
AD  - Mock, B. A.: Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950810320.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology; Animal Breeding
N2  - The interval of mouse chromosome 1 extending from Idh-1 to Pep-3 harbours the natural resistance gene Ity/Lsh/Bcg; it controls the outcome of infection with Salmonella typhimurium, Leishmania donovani, and several Mycobacterium species. This region also contains a DNA repair gene, Rep-1, which determines the rapidity with which double-strand breaks in chromatin are repaired. BALB/cAnPt and DBA/2N mice differ in their phenotypic expression of these genes. To generate appropriate strains of mice for the study of these genes, a series of 10 C.D2 congenic strains recombinant across a 28-centimorgan interval of mouse chromosome 1 extending from Idh-1 to Pep-3 were derived from crosses of the C.D2-Idh-1Pep-3 congenic strain back to BALB/cAn. Analyses of these recombinant strains will allow the correlation of biological-immunological phenotypes with defined genetic regions.
KW  - congenic strains
KW  - disease resistance
KW  - DNA
KW  - DNA repair
KW  - genes
KW  - genetics
KW  - parasites
KW  - resistance
KW  - strains
KW  - Leishmania donovani
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - BCG resistance
KW  - congenic
KW  - deoxyribonucleic acid
KW  - immunity to Salmonella typhimurium
KW  - leishmaniasis resistance
KW  - repair
KW  - resistance to disease
KW  - villin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950810320&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Size heterogeneity among antigenically related Giardia lamblia variant-specific surface proteins is due to differences in tandem repeat copy number.
AU  - Mowatt, M. R.
AU  - Nguyen, B. Y. T.
AU  - Conrad, J. T.
AU  - Adam, R. D.
AU  - Nash, T. E.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1994///
VL  - 62
IS  - 4
SP  - 1213
EP  - 1218
SN  - 0019-9567
AD  - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804774.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology
N2  - An epitope that is conserved among variant-specific surface proteins (VSPs) expressed by cloned trophozoite lines derived from the independent Giardia lamblia [Giardia duodenalis] isolates WB, G3M, Be-2 and CAT was studied. The epitope recognized by MAb 6E7 lies entirely within the region of tandemly repeated 65-amino acid units that is characteristic of these size-variant VSPs. Northern (RNA) hybridization, cDNA cloning and DNA sequence analysis indicated that size heterogeneity among these VSPs is due to differences in the number of repetitive units.
KW  - amino acid sequences
KW  - antigenic variation
KW  - antigens
KW  - genes
KW  - human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804774&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phagocytosis of medically important yeasts by polymorphonuclear leukocytes.
AU  - Lyman, C. A.
AU  - Walsh, T. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1994///
VL  - 62
IS  - 4
SP  - 1489
EP  - 1493
SN  - 0019-9567
AD  - Lyman, C. A.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200670.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Using a modified fluorescence quenching assay to distinguish between attached and ingested organisms, percent phagocytosis of several medically important yeasts was determined. The percentages of phagocytosis of serum-opsonized Candida albicans, C. tropicalis, C. parapsilosis and Torulopsis glabrata were all comparable at 37°C. There was significantly less phagocytosis of Cryptococcus neoformans and Trichosporon beigelii isolates (P&lt;0.001). It is concluded that phagocytosis of Candida albicans by polymorphonuclear leukocytes is comparable to that of species other than C. albicans but is significantly greater than that of the basidiomycetous yeasts T. beigelii and Cryptococcus neoformans.
KW  - immunology
KW  - neutrophils
KW  - phagocytosis
KW  - yeasts
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - Cryptococcus neoformans
KW  - Trichosporon beigelii
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Torulopsis
KW  - Pezizomycotina
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200670&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti.
AU  - Raghavan, N.
AU  - Freedman, D. O.
AU  - Fitzgerald, P. C.
AU  - Unnasch, T. R.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1994///
VL  - 62
IS  - 5
SP  - 1901
EP  - 1908
SN  - 0019-9567
AD  - Raghavan, N.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940803469.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 9001-06-3.  Subject Subsets: Helminthology
N2  - While there is no direct evidence demonstrating the existence of protective immunity to Wuchereria bancrofti infection in humans, the presence of individuals, in populations in areas where infection is endemic, with no clinical evidence of past or current infection despite appreciable exposure to the infective larvae, suggests that protective immunity to filarial parasites may occur naturally. Earlier work indicated that such putatively immune individuals generated antibodies to a 43 000 MW antigen from larval extracts of Brugia malayi that was recognized by only 8% of the infected population. With rabbit antiserum raised against this 43 000 MW antigen, a recombinant clone, WbN43, with an insert size of 2.3 kb, was identified from a Wuchereria bancrofti genomic expression library. The recombinant fusion protein was differentially recognized by the putatively immune individuals but not by the infected patients. The coding sequence (684 bp) from the 5′ end had significant sequence similarity to chitinases from Serratia marcescens, Bacillus circulans, Streptomyces plicatus, and B. malayi. Peptide sequencing of the expressed product also defined a chitinase-like sequence. Molecular characterization indicated WbN43 to be a low-copy-number gene, with expression predominantly in infective larvae and microfilariae but not in adult parasites.
KW  - antigens
KW  - chitinase
KW  - helminths
KW  - human diseases
KW  - immunity
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - recombinant antigens
KW  - man
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803469&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Giardia lamblia infections in adult mice.
AU  - Byrd, L. G.
AU  - Conrad, J. T.
AU  - Nash, T. E.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1994///
VL  - 62
IS  - 8
SP  - 3583
EP  - 3585
SN  - 0019-9567
AD  - Byrd, L. G.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940807147.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology
N2  - An adult mouse-Giardia lamblia [Giardia duodenalis] model was developed and used to study host-parasite interactions, including antigenic variation. The H7/1 clone of isolate GS infected mice consistently and produced infections in 14 mouse strains tested. Infection patterns were mouse strain and Giardia isolate dependent. Antigenic variation occurred in immunocompetent mice but not in mice with severe combined immunodeficiency.
KW  - animal models
KW  - experimental infections
KW  - giardiasis
KW  - host parasite relationships
KW  - laboratory animals
KW  - parasites
KW  - strains
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - mice
KW  - Muridae
KW  - protozoa
KW  - rodents
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - giardiosis
KW  - parasite host relationships
KW  - Laboratory Animal Science (LL040) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940807147&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HYP1, a hydrophobin gene from Aspergillus fumigatus, complements the rodletless phenotype in Aspergillus nidulans.
AU  - Parta, M.
AU  - Chang, Y.
AU  - Rulong, S.
AU  - Pinto-DaSilva, P.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1994///
VL  - 62
IS  - 10
SP  - 4389
EP  - 4395
SN  - 0019-9567
AD  - Parta, M.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19951203330.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
N2  - A. fumigatus produces conidia that are highly dispersible and resistant to degradation. These properties were analysed by studying the rodlets which form the outer spore coat protein. Degenerate primers based on hydrophobins in other fungi were applied to genomic DNA from A. fumigatus in PCR. A product of this reaction with similarity to an A. nidulans gene as judged by Southern hydridization was chosen for further study. Cloning and sequencing revealed a gene with 2 introns which encodes a protein of 159 amino acids. Structural characteristics consistent with those of other fungal hydrophobin genes, especially conserved cysteine residues, are present. The expression of the gene is limited to the developmental stages in which maturing conidiophores are present. This A. fumigatus gene, HYP1, was used to transform a mutant strain of A. nidulans that lacks rodlets. Transformants with a single copy of HYP1, was used to transform a mutant strain of A. nidulans that lacks rodlets. Transformants with a single copy of HYP1 expressed a rodlet layer on their conidia as observed by freeze-fracture electron microscopy.
KW  - genes
KW  - genetics
KW  - mutants
KW  - nucleotide sequences
KW  - phenotypes
KW  - Aspergillus fumigatus
KW  - Emericella nidulans
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Emericella
KW  - Aspergillus nidulans
KW  - DNA sequences
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203330&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression and antigenicity of Plasmodium falciparum major merozoite surface protein (MSP119) variants secreted from Saccharomyces cerevisiae.
AU  - Kaslow, D. C.
AU  - Hui, G.
AU  - Kumar, S.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1994///
VL  - 63
IS  - 2
SP  - 283
EP  - 289
SN  - 0166-6851
AD  - Kaslow, D. C.: Molecular Vaccine Section, Building 4, Room B1-37, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802834.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Four antigenic variants of the 19 kDa carboxy terminal fragment of Plasmodium falciparum merozoite surface protein, MSP1 (MSP119), were expressed in Saccharomyces cerevisiae as histidine-tagged, secreted polypeptides (rMSP119s). Structural analysis of the rMSP119s indicated that a single amino acid change (E to Q) in the first EGF-like domain of the yeast-secreted rMSP19 proteins caused a significant change in their disulfide bond-dependent conformation. The antigenicity of the rMSP119s were qualitatively and quantitatively analyzed by direct and competitive binding ELISAs. The data indicated that conserved and variant B cell determinants of MSP119, as well as epitopes that are known targets of protective antibodies, were recreated authentically in the rMSP119s.From AS&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Four antigenic variants of the 19 000 MW carboxy terminal fragment of Plasmodium falciparum merozoite surface protein, MSP1 (MSP119), were expressed in Saccharomyces cerevisiae as histidine-tagged, secreted polypeptides (rMSP119s). Structural analysis of the rMSP119s indicated that a single amino acid change (E to Q) in the first EGF-like domain of the yeast-secreted rMSP19 proteins caused a significant change in their disulfide bond-dependent conformation. The antigenicity of the rMSP119s were qualitatively and quantitatively analyzed by direct and competitive binding ELISAs. The data indicated that conserved and variant B cell determinants of MSP119, as well as epitopes that are known targets of protective antibodies, were recreated authentically in the rMSP119s.
KW  - amino acid sequences
KW  - antigenic variation
KW  - antigens
KW  - epitopes
KW  - Merozoites
KW  - parasites
KW  - Proteins
KW  - recombinant proteins
KW  - surface antigens
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - antigenic polymorphism
KW  - antigenicity
KW  - immunogens
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802834&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes.
AU  - Dolan, S. A.
AU  - Proctor, J. L.
AU  - Alling, D. W.
AU  - Okubo, Y.
AU  - Wellems, T. E.
AU  - Miller, L. H.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1994///
VL  - 64
IS  - 1
SP  - 55
EP  - 63
SN  - 0166-6851
AD  - Dolan, S. A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, NIH Building 4, Room 126 Bethesda, MD 20892, USA.
N1  - Accession Number: 19940805184.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Four clones of Plasmodium falciparum with differing specificities for erythrocyte invasion were studied using erythrocytes that are mutant for either glycophorin A or B, and enzyme modification of the erythrocyte surface with neuraminidase and trypsin. Neuraminidase alone abolished invasion of 2 parasite clones (Dd2, FCR3/A2: these invade after trypsin treatment alone). A 3rd clone (7G8) was unable to invade trypsin-treated erythrocytes. The 4th-clone (HB3) was able to invade after either neuraminidase or trypsin treatment. The receptor for invasion of trypsin-treated erythrocytes was explored in 2 ways: treatment of trypsin-treated normal cells with neuraminidase, and trypsin treatment of glycophorin B-deficient cells. Both treatments eliminated invasion by all clones, indicating that the trypsin-independent pathway uses sialic acid and glycophorin B. To identify parasite proteins involved in the different pathways, erythrocyte binding assays were performed with soluble parasite proteins from each clone. Based on binding assays using erythrocytes that lack glycophorin A, the parasite protein known as EBA-175 appears to bind predominantly to glycophorin A. In contrast, the glycophorin B pathway does not appear to involve EBA-175, as binding of EBA-175 was similarly reduced to trypsin-treated normal and trypsin-treated glycophorin B-deficient erythrocytes. The glycophorin B-dependent, sialic acid-dependent invasion of trypsin-treated normal erythrocytes uses a different parasite ligand, indicating 2 or more sialic-dependent pathways for invasion. Clone 7G8, which cannot invade trypsin-treated erythrocytes, may be missing the ligand for invasion via glycophorin B. Redundancy in the invasion process may give a selective advantage to parasites that must survive in polymorphic human populations.
KW  - cell invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - human diseases
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - blood red cells
KW  - glycophorin B
KW  - glycophorins
KW  - parasite host relationships
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805184&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetoplastida display naturally occurring ancillary DNA-containing structures.
AU  - Miyahira, Y.
AU  - Dvorak, J. A.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1994///
VL  - 65
IS  - 2
SP  - 339
EP  - 349
SN  - 0166-6851
AD  - Miyahira, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, Room 106, 12441 Parklawn Drive, Rockville, MD 20852-1727, USA.
N1  - Accession Number: 19950800977.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology
N2  - Kinetoplast-derived, DNA-containing structures were found in several members of the order Kinetoplastida. The structures, for which the name ancillary DNA-containing structures (aDNA) is proposed, were discovered during the course of low-light-level video fluorescence microscopy studies using several nucleic acid-specific fluorescent reagents. DNase treatment and supravital stain with Höechst 33342 confirmed that aDNA is not an artifact of specimen preparation. Fluorescent in situ hybridization using either a 122-bp kinetoplast DNA-specific probe derived from a conserved region of minicircle DNA or a 188-bp nuclear DNA-specific probe derived from highly repetitive nuclear DNA demonstrated that aDNA is derived from the kinetoplast and not the nucleus. However, the structures do not contain minicircle DNA replication intermediates. Immunofluorescence assays using an anti-mitochondrial protein antibody, anti-mtp 70, demonstrated that the structures contain mitochondrial protein and confirmed their kinetoplast origin. The frequency of occurrence of aDNA varies markedly between members of the Kinetoplastida. In the case of Trypanosoma cruzi stocks, the percentage of cells with aDNA was positively correlated to the population doubling time of the stock. However, there was no statistically significant relationship between the developmental or replicative stage of the parasite and the frequency of aDNA. An inhibitor of DNA topoisomerase I had no effect upon the frequency of aDNA. An inhibitor of DNA topoisomerase II gave equivocal results depending upon the parasite stock used. It is speculated that aDNA may be the morphological consequence of a yet-to-be-determined biological process intrinsic to, but variable within, the Kinetoplastida.
KW  - DNA
KW  - human diseases
KW  - molecular genetics
KW  - parasites
KW  - Kinetoplastida
KW  - protozoa
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - ancillary DNA
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800977&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Host specificity of ribosomal DNA variation in sylvatic Trypanosoma cruzi from North America.
AU  - Clark, C. G.
AU  - Pung, O. J.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1994///
VL  - 66
IS  - 1
SP  - 175
EP  - 179
SN  - 0166-6851
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Building 4/Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950801110.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Eighteen sylvatic trypanosome isolates (13 from raccoon Procyon lotor, 4 from opossum Didelphis marsupialis and one from Triatoma sanguisuga, all from Georgia, USA, except one from raccoon in Maryland) and 4 human Trypanosoma cruzi reference strains (all from Brazil) were studied. Riboprinting (based on digesting PCR amplified SSU-rDNA) of the 17 sylvatic isolates from mammals resulted in 2 distinct patterns that corelated with the host from which they had been cultured, one pattern being seen only in the opossum isolates, the other in the raccoon isolates. The riboprint obtained for the isolate from Triatoma sanguisuga was identical to those of the raccoon isolates. The term "ribodeme" is coined for populations which share the same riboprint pattern: ribodeme I consisted of the raccoon, Triatoma sanguisuga and 3 of the human isolates, ribodeme II of the opossum isolates, and ribodeme III of one of the human isolates. Findings in the North American isolates are consistent with a "founder effect" and vertical transmission. It is suggested that Trypanosoma cruzi may only have entered once into the population of each mammal species in the area.
KW  - Chagas' disease
KW  - disease vectors
KW  - epidemiology
KW  - human diseases
KW  - molecular genetics
KW  - molecular taxonomy
KW  - parasites
KW  - ribosomal DNA
KW  - Georgia
KW  - Maryland
KW  - USA
KW  - Didelphis marsupialis
KW  - Hemiptera
KW  - Procyon lotor
KW  - protozoa
KW  - Reduviidae
KW  - Sarcomastigophora
KW  - Triatoma sanguisuga
KW  - Triatominae
KW  - Trypanosoma cruzi
KW  - Trypanosomatidae
KW  - Didelphis
KW  - Didelphidae
KW  - Didelphimorphia
KW  - marsupials
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - Procyon
KW  - Procyonidae
KW  - Fissipeda
KW  - carnivores
KW  - Heteroptera
KW  - Hemiptera
KW  - Protozoa
KW  - Reduviidae
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Triatoma
KW  - Triatominae
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southeastern States of USA
KW  - biochemical genetics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801110&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.
AU  - Schubert, U.
AU  - Strebel, K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 4
SP  - 2260
EP  - 2271
SN  - 0022-538X
AD  - Schubert, U.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003366.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
KW  - activity
KW  - human diseases
KW  - localization
KW  - Vpu protein
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003366&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of humam immunodeficiency virus type 1.
AU  - Van Lint, C.
AU  - Ghysdael, J.
AU  - Paras, P. Jr.
AU  - Burny, A.
AU  - Verdin, E.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 4
SP  - 2632
EP  - 2648
SN  - 0022-538X
AD  - Van Lint, C.: Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003362.  Publication Type: Journal Article.  Language: English.  Number of References: 93 ref.
KW  - genes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - nucleotide sequences
KW  - pol gene
KW  - regulation
KW  - transcription
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA sequences
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003362&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spontaneous substitutions in the vicinity of the V3 analog affect cell tropism and pathogenicity of simian immunodeficiency virus.
AU  - Hirsch, V. M.
AU  - Martin, J. E.
AU  - Dapolito, G.
AU  - Elkins, W. R.
AU  - London, W. T.
AU  - Goldstein, S.
AU  - Johnson, P. R.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 4
SP  - 2649
EP  - 2661
SN  - 0022-538X
AD  - Hirsch, V. M.: Immunodeficiency Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Twinbrook Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA.
N1  - Accession Number: 19952003373.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
KW  - animal models
KW  - envelope proteins
KW  - mutations
KW  - pathogenicity
KW  - tropisms
KW  - man
KW  - simian immunodeficiency virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003373&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type 1 strains: evidence for interspecies transmission.
AU  - Koralnik, I. J.
AU  - Boeri, E.
AU  - Saxinger, W. C.
AU  - Lo Monico, A.
AU  - Fullen, J.
AU  - Gessian, A.
AU  - Guo, H-G.
AU  - Gallo, R. C.
AU  - Markham, P.
AU  - Kalyanaraman, V.
AU  - Hirsch, V.
AU  - Allan, J.
AU  - Murthy, K.
AU  - Alford, P.
AU  - Slattery, J. P.
AU  - O'Brien, S. J.
AU  - Franchini, G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 4
SP  - 2693
EP  - 2707
SN  - 0022-538X
AD  - Koralnik, I. J.: Correspondence address: G. Franchini, Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg 37, Rm 6H01, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003364.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
KW  - ancestry
KW  - env gene
KW  - human diseases
KW  - phylogeny
KW  - transmission
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - HTLV-BLV group
KW  - simian T-cell leukaemia/lymphotropic virus type I
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003364&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of minireovirus as a Norwalk-like virus in pediatric patients with gastroenteritis.
AU  - Lew, J. F.
AU  - Petric, M.
AU  - Kapikian, A. Z.
AU  - Jiang, X.
AU  - Estes, M. K.
AU  - Green, K. Y.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 5
SP  - 3391
EP  - 3396
SN  - 0022-538X
AD  - Lew, J. F.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 7, Rm 129, 5000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010411.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - In 1977, 30- to 32-nm virus-like particles, named minireovirus because of their unique morphologic appearance, were detected by electron microscopy in the stools of Canadian infants and young children with gastroenteritis. Sequence analysis of approximately 2 800 consecutive bases derived from overlapping PCR clones of a recent minireovirus clinical isolate showed 52% nucleotide sequence identity with the Norwalk virus sequence and, in addition, demonstrated that the genomic organizations of these two viruses were similar. These data show that minireovirus is a Norwalk-like virus and should now also be included in the Caliciviridae family.
KW  - children
KW  - gastroenteritis
KW  - human diseases
KW  - identification
KW  - infants
KW  - Canada
KW  - North America
KW  - Caliciviridae
KW  - man
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Norovirus
KW  - Caliciviridae
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - minireovirus
KW  - Norwalk-like virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope.
AU  - Willey, R. L.
AU  - Theodore, T. S.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 7
SP  - 4409
EP  - 4419
SN  - 0022-538X
AD  - Willey, R. L.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952006358.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref.
KW  - amino acids
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006358&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex Class II expression and CD4+ T cells.
AU  - Giese, N. A.
AU  - Giese, T.
AU  - Morse, H. C. III
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 9
SP  - 5819
EP  - 5824
SN  - 0022-538X
AD  - Giese, N. A.: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001713.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
KW  - animal models
KW  - antigens
KW  - CD4+ lymphocytes
KW  - human diseases
KW  - major histocompatibility complex
KW  - pathogenesis
KW  - mice
KW  - Retroviridae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenicity
KW  - CD4+ cells
KW  - histocompatibility complex
KW  - immunogens
KW  - murine AIDS
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001713&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.
AU  - Engelman, A.
AU  - Hickman, A. B.
AU  - Craigie, R.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 9
SP  - 5911
EP  - 5917
SN  - 0022-538X
AD  - Engelman, A.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001702.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9007-49-2. 
KW  - binding
KW  - DNA
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - processing
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001702&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A lion lentivirus related to feline immunodeficiency virus: epidemiologic and phylogenetic aspects.
AU  - Brown, E. W.
AU  - Yuhki, N.
AU  - Packer, C.
AU  - O'Brien, S. J.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 9
SP  - 5953
EP  - 5968
SN  - 0022-538X
AD  - Brown, E. W.: Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19942217183.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Registry Number: 9068-38-6.  Subject Subsets: Veterinary Science; Veterinary Science
N2  - A serological survey for antibodies to feline immunodeficiency virus (FIV) detected an endemic lentivirus in 90% of over 400 free-ranging African and Asian lions (Panthera leo). A lion lentivirus (FIV-Ple) was isolated by infection of lion lymphocytes in vitro. Seroconversion was found in 2 Serengeti lions. There was no evidence for maternal transmission as a major route of infections in lions. A phylogenetic analysis of cloned FIV-Ple pol gene sequences from 27 lions from 4 African populations (Serengeti Reserve, Ngorongoro Crater, Lake Manyara and Kruger Park) detected high intra- and interindividual genetic diversity. Three FIV-Ple phylogenetic clusters or clades were identified with phenetic, parsimony and likelihood analyses. The 3 clades, which occurred not only together in the same population but throughout Africa, were as divergent from each other as were homologous pol sequences of lentivirus isolates from distinct feline species such as the puma and domestic cat. The FIV-Ple clades were more closely related to each other than to other feline lentiviruses (monophyletic for lion species), suggesting that the ancestors of FIV-Ple evolved in geographically isolated lion populations that converged recently. There is no clear evidence of FIV-Ple-associated pathology, suggesting a historic genetic accomodation of the lion lentivirus to its host leading to coevolved host-parasite symbiosis (or commensalism) in the population similar to that suggested for endemic simian immunodeficiency virus without pathology in free-ranging African monkey species.
KW  - immunoblotting
KW  - molecular biology
KW  - nucleotide sequences
KW  - phylogeny
KW  - polymerase chain reaction
KW  - reverse transcriptase
KW  - viral diseases
KW  - Africa
KW  - Felidae
KW  - feline immunodeficiency virus
KW  - lentivirus
KW  - man
KW  - Panthera
KW  - retroviridae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Felidae
KW  - DNA sequences
KW  - PCR
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.
AU  - Vicenzi, E.
AU  - Dimitrov, D. S.
AU  - Engelman, A.
AU  - Migone, T. S.
AU  - Purcell, D. F. J.
AU  - Leonard, J.
AU  - Englund, G.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 12
SP  - 7879
EP  - 7890
SN  - 0022-538X
AD  - Vicenzi, E.: Correspondence address: M. A. Martin, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007089.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref.
KW  - deletions
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - long terminal repeat
KW  - nucleotide analysis
KW  - U5 region
KW  - viral DNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007089&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II.
AU  - Giri, A.
AU  - Markham, P.
AU  - Digilio, L.
AU  - Hurteau, G.
AU  - Gallo, R. C.
AU  - Franchini, G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1994///
VL  - 68
IS  - 12
SP  - 8392
EP  - 8395
SN  - 0022-538X
AD  - Giri, A.: Correspondence address: G. Franchini, Laboratory of Tumor Cell Biology, Bldg. 37, Rm. 6A01, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007042.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
KW  - human diseases
KW  - chimpanzees
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - human t-cell lymphotropic virus type ii
KW  - man
KW  - retroviridae
KW  - Pan
KW  - Pongidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - HTLV-BLV group
KW  - simian T-cell lymphotropic virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007042&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiology of human immunodeficiency virus infection in children.
AU  - Willoughby, A.
JO  - Annals of Allergy
JF  - Annals of Allergy
Y1  - 1994///
VL  - 72
IS  - 3
SP  - 185
EP  - 193
SN  - 0003-4738
AD  - Willoughby, A.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA.
N1  - Accession Number: 19952010562.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
KW  - children
KW  - epidemiology
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infections
KW  - reviews
KW  - viral diseases
KW  - North America
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010562&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The price of mammography in the United States: data from the National Survey of mammography facilities.
AU  - Breen, N.
AU  - Brown, M. L.
JO  - Milbank Quarterly
JF  - Milbank Quarterly
Y1  - 1994///
VL  - 72
IS  - 3
SP  - 431
EP  - 450
SN  - 0887-378X
AD  - Breen, N.: (N. Breen) Applied Research Branch, National Cancer Institute, Executive Plaza North, Room 313, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952000732.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Public Health
N2  - This paper deals with costs in the USA specificially. In many other countries with screening programmes such as the UK cost is not an issue. Danielle Horton
KW  - breast
KW  - breast cancer
KW  - costs
KW  - neoplasms
KW  - screening
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - costings
KW  - screening tests
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000732&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary effects on exercising muscle metabolism and performance by 31P-MRS.
AU  - Larson, D. E.
AU  - Hesslink, R. L.
AU  - Hrovat, M. I.
AU  - Fishman, R. S.
AU  - Systrom, D. M.
JO  - Journal of Applied Physiology
JF  - Journal of Applied Physiology
Y1  - 1994///
VL  - 77
IS  - 3
SP  - 1108
EP  - 1115
SN  - 8750-7587
AD  - Larson, D. E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19951413544.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 67-07-2.  Subject Subsets: Human Nutrition
N2  - The effect of diet on short-term exercise capacity, skeletal muscle pH and bioenergetic state was investigated by 31P-magnetic resonance spectroscopy in 5 male and 4 female, healthy adults. Subjects performed incremental quadriceps exercise to exhaustion after 5 days of high-carbohydrate (HCHO) or high-fat (HFAT) diet randomly assigned in crossover design and separated by a 2.5-day period of ad libitum mixed diet. Simultaneous measurements were made of pulmonary gas exchange, minute ventilation and quadriceps muscle pH and phosphorylation potential. At rest and peak exercise, respiratory exchange ratio and minute ventilation were higher after HCHO than after HFAT (P&lt;0.05), indicating greater CHO utilization. HCHO did not increase peak oxygen consumption (VO2) but increased exercise duration (339±34 s for HCHO vs. 308±25 s for HFAT; P&lt;0.05). HCHO was associated with a blunted early decrease in phosphocreatine (PCr)/P intracellular (Pi) vs. VO2 (-4.1±0.7 × 10-2 min/ml for HCHO vs. -5.6±1.2 × 10-2 for HFAT; P&lt;0.05). The slope of PCr/Pi vs. VO2, before and after the PCr-threshold, was correlated with exercise time. Results suggest that a dietary intake high in CHO improves exercise efficiency through beneficial effects on intracellular phosphorylation potential.
KW  - adults
KW  - carbohydrate metabolism
KW  - carbohydrates
KW  - exercise
KW  - fats
KW  - glycolysis
KW  - intake
KW  - metabolism
KW  - oxygen consumption
KW  - performance
KW  - pH
KW  - phosphocreatine
KW  - skeletal muscle
KW  - spectroscopy
KW  - ventilation
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - creatine phosphate
KW  - hydrogen ion concentration
KW  - potential of hydrogen
KW  - saccharides
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413544&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Complementation of an Escherichia coli glycolysis mutant by Giardia lamblia triosephosphate isomerase.
AU  - Mowatt, M. R.
AU  - Weinbach, E. C.
AU  - Howard, T. C.
AU  - Nash, T. E.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1994///
VL  - 78
IS  - 1
SP  - 85
EP  - 92
SN  - 0014-4894
AD  - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802328.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The Giardia lamblia triosephosphate isomerase (TIM) gene was cloned using a probe generated by a polymerase chain reaction employing primers complementary to highly conserved regions of TIM. The nucleotide sequence predicts a protein 38 and 47% identical to TIM from prokaryotic and eukaryotic sources, respectively. The TIM gene lacks introns and is transcribed to yield a polyadenylated mRNA with an extremely short 5′ untranslated region. The Giardia TIM gene complemented an Escherichia coli triosephosphate isomerase deletion mutant.
KW  - complementation
KW  - enzymes
KW  - genes
KW  - human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Giardia duodenalis
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - Escherichia coli glycolysis
KW  - triosephosphate isomerase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802328&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxoplasma gondii: acquired ocular toxoplasmosis in the murine model, protective role of TNF-α and IFN-γ.
AU  - Gazzinelli, R. T.
AU  - Brézin, A.
AU  - Li, Q.
AU  - Nussenblatt, R. B.
AU  - Chan, C. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1994///
VL  - 78
IS  - 2
SP  - 217
EP  - 229
SN  - 0014-4894
AD  - Gazzinelli, R. T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940802798.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9008-11-1, 308079-78-9.  Subject Subsets: Protozoology; Tropical Diseases
N2  - The eyes and brains from C57BL/6 mice infected with an avirulent strain of Toxoplasma gondii (ME49) were studied. Focal ocular inflammation and retinal pigment epithelial involvement were commonly observed after 15 days of infection. Four weeks pi a stable number of cysts was observed in the brain but rarely in the eye, and they did not elicit an inflammatory response. In most of the ocular lesions the presence of the parasite could not be demonstrated even by PCR. B1 DNA fragments of T. gondii were detected in only 4 of 11 eyes tested by PCR and Southern blot hybridization. Treatment of mice with MAbs against T cells (CD4 plus CD8) or cytokines (IFN-γ or TNF-α) resulted in a marked increase of ocular lesions, more often associated with the presence of the parasite and the severity of inflammatory response.
KW  - brain
KW  - diagnosis
KW  - disease models
KW  - experimental infections
KW  - eyes
KW  - immune response
KW  - immunology
KW  - interferon
KW  - monoclonal antibodies
KW  - parasites
KW  - pathology
KW  - polymerase chain reaction
KW  - tumour necrosis factor
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cachectin
KW  - cachexin
KW  - cerebrum
KW  - immunity reactions
KW  - immunological reactions
KW  - PCR
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802798&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: differential lysis of two developmental stages of malaria sporozoites by the alternative pathway of complement.
AU  - Touray, M. G.
AU  - Seeley, D. C., Jr.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1994///
VL  - 78
IS  - 3
SP  - 294
EP  - 301
SN  - 0014-4894
AD  - Touray, M. G.: Laboratory of Malaria Research, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940805556.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 9007-36-7.  Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology
N2  - Whereas 86% of Plasmodium gallinaceum sporozoites from oocysts in Aedes aegypti were lysed when incubated in fresh chicken serum in vitro, only 24% of sporozoites from salivary glands were lysed under identical incubation conditions. Preincubation of oocyst sporozoites in a homogenate of female A. aegypti salivary glands did not diminish their susceptibility to lysis by serum, indicating that lysis was mediated by the interaction of serum factors with parasite-specific molecules. The lytic activity of fresh chicken serum was abrogated by incubating for 45 minutes at 56°C or chelating with EDTA. Fresh chicken serum specifically depleted of Ca2+, by chelating with EGTA in the presence of Mg2+, retained its ability to lyse oocyst sporozoites. The lysis of salivary gland sporozoites mediated by chicken antisporozoite serum was abrogated by EGTA, indicating that the antibody-dependent complement pathway in chicken serum is blocked by EGTA. Because oocyst sporozoite lysis by serum was heat sensitive and Mg2+ dependent, but Ca2+ independent, it is concluded that lysis was mediated by the alternative pathway of complement.
KW  - complement
KW  - disease vectors
KW  - lysis
KW  - parasites
KW  - serum
KW  - sporozoites
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805556&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of two cysteine-rich, lipophilic proteins on the surface of Plasmodium knowlesi ookinetes: Pks20 and Pks24.
AU  - Fried, M.
AU  - Gwadz, R. W.
AU  - Kaslow, D. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1994///
VL  - 78
IS  - 3
SP  - 326
EP  - 330
SN  - 0014-4894
AD  - Fried, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940805559.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Of 30 MAbs produced using mice immunized 3 times with 4 × 106Plasmodium knowlesi, 25 reacted with the surface of P. knowlesi ookinetes by IFA. 15 culture supernatants from these surface-positive hybridoma cell lines were further characterized by immunoblotting with non-reduced SDS extracts of P. knowlesi ookinetes. 11 culture supernatants reacted with a 24 000 MW protein (Pks24), 3 with a 20 000 MW protein (Pks20), one with an 18 000 MW protein and one to a triplet of proteins of MW about 200 000. Pks24 and Pks20 were shown to be cysteine-rich, lipophilic proteins. Data are presented which suggest that Pks24 and Pks20 are homologues of the family of epidermal growth factor-like transmission-blocking target antigens present in P. falciparum, P. gallinaceum and P. berghei (Pfs25, Pgs25, Pgs28 and Pbs21).
KW  - monoclonal antibodies
KW  - ookinetes
KW  - parasites
KW  - proteins
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805559&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium: parasite chitinase and its role in malaria transmission.
AU  - Shahabuddin, M.
AU  - Kaslow, D. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1994///
VL  - 79
IS  - 1
SP  - 85
EP  - 88
SN  - 0014-4894
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950801682.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 9001-06-3.  Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology
N2  - This review focuses on Plasmodium chitinase and the role that it plays in the malaria parasite's egress from the bloodmeal in the midgut of the insect vector. The formation of the mosquito peritrophic membrane (PM) is briefly described. It is suggested that to cross the PM the parasite has evolved a zymogen with chitinolytic activity that is activated by mosquito midgut protease. This may allow the parasite to cross the PM more efficiently and in synchrony with the mosquito's physiology. It is suggested that inhibiting these chitinases by chemotherapeutic agents or vaccine-induced antibodies may prove to be potent measures for controlling parasite transmission.
KW  - chitinase
KW  - disease transmission
KW  - disease vectors
KW  - human diseases
KW  - parasites
KW  - peritrophic membrane
KW  - reviews
KW  - transmission
KW  - Anopheles
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Staurosporine inhibits invasion of erythrocytes by malarial merozoites.
AU  - Ward, G. E.
AU  - Fujioka, H.
AU  - Aikawa, M.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1994///
VL  - 79
IS  - 3
SP  - 480
EP  - 487
SN  - 0014-4894
AD  - Ward, G. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803933.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Protozoology
N2  - Staurosporine, a protein kinase inhibitor, inhibited the invasion of rhesus monkey erythrocytes by Plasmodium knowlesi merozoites with an IC50 of 250 nM. The drug exerted its effects primarily on the merozoite, with little or no effect on the erythrocyte. Okadaic acid, an inhibitor of protein phosphatases, partially abrogated the inhibitory effects of staurosporine. Staurosporine arrested invasion at a step ultrastructurally similar to the arrest caused by cytochalasins B and D: the merozoite attaches, apically reorients, and forms a junction with the erythrocyte, but it does not internalize. It is suggested that protein phosphorylation within the merozoite plays an important role in the internalization step of invasion.
KW  - cell invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - invasion
KW  - merozoites
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium knowlesi
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - blood red cells
KW  - parasite host relationships
KW  - red blood cells
KW  - staurosporine
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803933&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage.
AU  - Saville, M. W.
AU  - Taga, K.
AU  - Foli, A.
AU  - Broder, S.
AU  - Tosato, G.
AU  - Yarchoan, R.
JO  - Blood
JF  - Blood
Y1  - 1994///
VL  - 83
IS  - 12
SP  - 3591
EP  - 3599
SN  - 0006-4971
AD  - Saville, M. W.: National Cancer Institute, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942007112.  Publication Type: Journal Article.  Language: English. 
KW  - Cells
KW  - HIV infections
KW  - Inhibition
KW  - Macrophages
KW  - Monocytes
KW  - Replication
KW  - human immunodeficiency virus infections
KW  - Interleukin-10
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007112&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - US dietary patterns associated with fat intake: the 1987 National Health Interview Survey.
AU  - Subar, A. F.
AU  - Ziegler, R. G.
AU  - Patterson, B. H.
AU  - Ursin, G.
AU  - Graubard, B.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994///
VL  - 84
IS  - 3
SP  - 359
EP  - 366
SN  - 0090-0036
AD  - Subar, A. F.: National Cancer Institute, Division of Cancer Prevention and Control, Surveillance Program, Applied Research Branch, 9000 Rockville Pike, EPN 313, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951403529.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Human Nutrition; Potatoes
N2  - Food frequency data were used to investigate dietary patterns associated with fat intake. Data from the 1987 National Health Interview Survey of 20 143 adults were used in the study. Intakes of vegetables, fruits, cereals, fish/chicken, low-fat milk, alcoholic beverages, vitamin C, percentage of energy from carbohydrates, carotenoids, folate, dietary fibre, carbohydrates and vitamin A decreased as percentage of energy from fat increased. Intakes of salty snacks, peanuts, processed and red meats, whole milk and cheese, dessert, eggs, fried potatoes, table fats, cholesterol, vitamin E, sodium, protein and energy increased with percentage of energy from fat. Results by demographic subgroups showed few differences from those found in the total population. Fat intake is consistently associated with specific dietary patterns. Such patterns need to be evaluated concurrently in studies of diet and chronic disease.
KW  - diet studies
KW  - fats
KW  - food groups
KW  - intake
KW  - nutrients
KW  - nutrition
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas.
AU  - Bhatia, K.
AU  - Spangler, G.
AU  - Gaidano, G.
AU  - Hamdy, N.
AU  - Dalla-Favera, R.
AU  - Magrath, I.
JO  - Blood
JF  - Blood
Y1  - 1994///
VL  - 84
IS  - 3
SP  - 883
EP  - 888
SN  - 0006-4971
AD  - Bhatia, K.: Building 10/13c205, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942007117.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - genomes
KW  - Mutations
KW  - Non-Hodgkin's lymphoma
KW  - Pathogenesis
KW  - AIDS
KW  - C-myc gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007117&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary sources of fats and cholesterol in US children aged 2 through 5 years.
AU  - Thompson, F. E.
AU  - Dennison, B. A.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994///
VL  - 84
IS  - 5
SP  - 799
EP  - 806
SN  - 0090-0036
AD  - Thompson, F. E.: National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951403506.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition; Dairy Science
N2  - A study of lipid intakes among preschool children had 3 objectives: it analysed the contributions of 38 food groups to fat, saturated fat and cholesterol intakes; estimated the effects of food substitutions on intakes; and examined demographic differences in food group intake and food group sources of these lipids. The sample consisted of 547 children, 2 to 5 years old, from the US Department of Agriculture's 1985 and 1986 Continuing Surveys of Food Intakes by Individuals. Dietary information for 4 non-consecutive days throughout a year was used. All foods were classified into groups and the lipids contributed from each group were computed. More than 80% of the children consumed more total fat, saturated fats and cholesterol than is recommended. The major source of total fat and saturated fats was whole milk; the major sources of dietary cholesterol were eggs and whole milk. Children's food consumption patterns differed by region of the country and race/ethnicity, providing opportunities to refine nutrition education interventions and evaluations. By substituting lower-fat foods for the major sources of saturated fats, significant reductions in preschool children's intakes of saturated fats, fat and dietary cholesterol could be achieved.
KW  - children
KW  - cholesterol
KW  - cows
KW  - diet studies
KW  - diets
KW  - fats
KW  - intake
KW  - milk
KW  - milk consumption
KW  - sources
KW  - USA
KW  - cattle
KW  - man
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Milk and Dairy Produce (QQ010) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403506&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16.
AU  - Kirnbauer, R.
AU  - Hubbert, N. L.
AU  - Wheeler, C. M.
AU  - Becker, T. M.
AU  - Lowry, D. R.
AU  - Schiller, J. T.
AU  - Galloway, D. A.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 7
SP  - 494
EP  - 499
SN  - 0027-8874
AD  - Kirnbauer, R.: (J.T. Schiller) Laboratory of Cellular Oncology, National Cancer Institute, Bldg. 36, Rm 1D19, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942027846.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - An ELISA was developed using newly developed HPV16 virus-like particles as antigens to detect anti-HPV16 virion IgG antibodies. These particles are comprised of HPV16 structural proteins that are self-assembled in insect cells after expression by recombinant baculoviruses. The sera of 122 women from New Mexico, USA whose HPV status had been previously evaluated by nucleic acid-based methods, were tested by this ELISA. The sera of 59% of women (32 of 54) positive for genital HPV16 DNA by polymerase chain reaction (PCR) were positive in the ELISA assay compared with sera from women who had tested negative for HPV DNA (P &lt;0.0005). In contrast, 6% of HPV DNA-negative women (two of 31) and 9% of women positive for low-risk HPV 6/11 DNA (one of 11) were ELISA positive by this criterion. The sera of women who were DNA positive for two additional high-risk HPV types were evaluated; the sera of 31% of HPV18-positive (four of 13) and 38% of HPV31-positive women (five of 13) were positive in the HPV16 particle ELISA. The sera of 75% of HPV16 DNA-positive women with severe dysplasias (12 of 16) gave positive ELISA results. The sera of 67% of women (28 of 42) who tested positive for HPV16 DNA by both PCR and the less sensitive ViraType assay tested positive in the ELISA compared with 33% of women (four of 12) who were positive by PCR but negative by ViraType (P &lt;0.05). The authors conclude that the majority of women with cervical HPV16 infection generate an IgG antibody response to conformationally dependent epitopes of HPV16 L1 that can be detected by ELISA. This particular ELISA, or a similar one incorporating virus-like particles of additional HPV types, may be useful in determining the natural history of high-risk HPV infection and perhaps help to identify women at risk for developing cervical cancer. [Denise A. Galloway discusses human papillomavirus capsids as a new approach to identify serological markers of HPV infection in an editorial on p474 of this issue.]From AS
KW  - diagnosis
KW  - ELISA
KW  - infections
KW  - New Mexico
KW  - North America
KW  - USA
KW  - human papillomaviruses
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Mountain States of USA
KW  - Western States of USA
KW  - Southwestern States of USA
KW  - Papillomaviridae
KW  - enzyme linked immunosorbent assay
KW  - Human papillomavirus
KW  - Papovaviridae
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduced risk of esophageal cancer associated with green tea consumption.
AU  - Gao, Y. T.
AU  - McLaughlin, J. K.
AU  - Blot, W. J.
AU  - Ji, B. T.
AU  - Dai, Q.
AU  - Fraumeni, J. F. Jr
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 11
SP  - 855
EP  - 858
SN  - 0027-8874
AD  - Gao, Y. T.: (J.K. McLaughlin) National Institutes of Health, Executive Plaza North, Rm. 415G, Rockville, MD 20852, USA.
N1  - Accession Number: 19942028225.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - Medical records of 1016 patients aged 30-74 years old who were diagnosed with oesophageal cancer from October 1, 1990, through January 31, 1993, were identified from the Shanghai Cancer Registry, which covers 6.8 million people in the urban area of Shanghai, China. Patient interviews were then conducted using a structured, standardized questionnaire to obtain information on demographic characteristics, residential history, height and weight, diet, smoking, alcohol and tea drinking, medical history, family history of cancer, occupation, physical activity, and reproductive history. Of the 902 patients interviewed, 734 (81.4%) had their disease pathologically confirmed. There were 1552 control subjects interviewed, including 240 alternates. All analyses of tea effects were conducted separately among men and women and all were adjusted for age. After further adjustment for other known confounders, a protective effect of green tea drinking on oesophageal cancer was observed among women (odds ratio [OR] = 0.50; 95% confidence interval [CI] = 0.30-0.83), and this risk decreased (P for trend ≤0.01) as tea consumption increased. Among men, the ORs were also below 1.00, although not statistically significant. ORs for green tea intake were estimated among those persons who neither smoked nor drank alcohol. In this subset, statistically significant decreases in risk among tea drinkers were observed for both men (OR = 0.43; 95% CI = 0.22-0.86; P for trend = 0.05) and women (OR = 0.40; 95% CI = 0.20-0.77; P for trend &lt;0.001). The authors conclude that this population-based, case-control study of oesophageal cancer in urban Shanghai suggests a protective effect of green tea consumption. Although these findings are consistent with studies in laboratory animals, indicating that green tea can inhibit oesophageal carcinogenesis, further investigations are definitely needed. From AS
KW  - green tea
KW  - neoplasms
KW  - oesophageal cancer
KW  - oesophagus
KW  - protection
KW  - tea
KW  - Asia
KW  - China
KW  - Camellia sinensis
KW  - Camellia
KW  - Theaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - esophagus
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028225&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Health claims about vitamin C and cancer.
AU  - Ziegler, R. G.
AU  - Byers, T.
T2  - Journal of the National Cancer Institute
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 11
SP  - 871
EP  - 872
SN  - 0027-8874
AD  - Ziegler, R. G.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, Rm 443, Rockville, MD 20852, USA.
N1  - Accession Number: 19942028224.  Publication Type: Correspondence.  Language: English.  Registry Number: 50-81-7.  Subject Subsets: Tropical Diseases
N2  - The correspondents comment on the implications of the negative result from an important intervention trial carried out on 40-69-year-olds from the general population of Linxian, China, a county with extremely high rates of oesophageal and gastric cardia cancer (ibid., 1993, 85, 1483).
KW  - ascorbic acid
KW  - failure
KW  - neoplasms
KW  - Nutrition
KW  - oesophagus
KW  - protection
KW  - stomach
KW  - Asia
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancer sites
KW  - cancers
KW  - esophagus
KW  - People's Republic of China
KW  - vitamin C
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028224&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Temporal patterns in colorectal cancer incidence, survival, and mortality from 1950 through 1990.
AU  - Chu, K. C.
AU  - Tarone, R. E.
AU  - Chow, W. H.
AU  - Hankey, B. F.
AU  - Ries, L. A. G.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 13
SP  - 997
EP  - 1006
SN  - 0027-8874
AD  - Chu, K. C.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19952002309.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Subject Subsets: Public Health
N2  - Colorectal cancer mortality rates among US white males remained relatively constant from 1950 through 1984 but declined sharply from 1985 through 1990. Those for US white females decreased consistently from 1950 through 1984, with an acceleration of the decline from 1985 through 1990. A study was planned to investigate patterns in incidence, survival, and mortality rates over time in order to examine possible reasons for the gender difference in mortality trends and for the decrease in the slope of the mortality trends for both males and females in the late 1980s. Incidence and survival data from the Connecticut Cancer Registry were examined to investigate the gender differences in mortality rates from 1950 through 1984. Incidence and survival data from the Surveillance, Epidemiology, and End Results (SEER) Programme were investigated to examine reasons for the abrupt downturn in mortality rates for both white males and white females beginning around 1985. During the period 1950 through 1984, the colorectal cancer incidence rates in Connecticut increased for males and declined slightly for females. Survival rates were similar for both sexes, increasing on average over 1% per year for both females and males from 1950 through 1984. Examination of SEER data from 1975 through 1990 revealed that for both males and females there were (1) declines in overall incidence and mortality rates beginning in the mid-1980s, (2) steady declines in distant disease incidence rates since 1975, (3) increases in regional disease incidence rates until the early 1980s followed by declines in the late 1980s, and (4) increases in local disease incidence rates until the mid-1980s followed by declines in the late 1980s. Age-period-cohort analyses of mortality rates indicated a statistically significant moderation of colorectal cancer risk with both advancing birth cohorts and recent calendar periods. The gender differences in colorectal cancer mortality rate trends observed from 1950 through 1984 are due to differences in incidence rate trends between males and females. Declining colorectal mortality rates in the late 1980s for males and females appear to reflect improved early detection. The peaking and subsequent decline of stage-specific incidence rates at later years for successively lower stage indicate sequential stage shifts as cancers are detected increasingly earlier over time. The increased use of sigmoidoscopy and faecal occult blood tests (triggering colonoscopy) appears to have played an important role in reducing colorectal cancer mortality. Improvements in birth cohort trends in risk for colorectal cancer for each sex suggest that lifestyle changes may have also contributed to the steady reductions in colorectal cancer mortality.
KW  - colon
KW  - colorectal cancer
KW  - disease prevalence
KW  - human diseases
KW  - mortality
KW  - neoplasms
KW  - rectum
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002309&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Metabolism of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by lactating Fischer 344 rats and their nursing pups.
AU  - Davis, C. D.
AU  - Ghoshal, A.
AU  - Schut, H. A. J.
AU  - Snyderwine, E. G.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 14
SP  - 1065
EP  - 1070
SN  - 0027-8874
AD  - Davis, C. D.: Laboratory of Experimental Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bldg. 37, Room 3C28, Bethesda, MD, USA.
N1  - Accession Number: 19951406314.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - To investigate the significance of rat milk as a route of exposure of the neonate to dietary heterocyclic amines, the metabolites of 2-amino-1-methyl-6phenylimidazo(4,5-b)pyridine (PhIP) in rat milk and in urine of nursing pups was examined. Lactating Fischer 344 rats with 5-day-old pups were given a single oral dose of [³H]PhIP 10 mg/kg. Milk was collected from the dams and urine from the pups and then the samples were analysed for metabolites of PhIP, using HPLC. PhIP-DNA adduct values in the tissues of the pups were estimated by 32P-post-labelling analysis. 3 radioactive peaks were observed by HPLC separation of milk samples: an unidentified early eluting peak, 4′-hydroxy-PhIP, and PhIP. 4 metabolites and the parent compound were found in urine of the pups nursed by dams given radiolabelled PhIP: PhIP-4′-O-glucuronide, PhIP-4′-sulfate, 4′-hydroxy-PhIP and N²-hydroxy-PhIP-N³-glucuronide. 4′-Hydroxy-PhIP and its conjugates contributed about 60% of the radioactivity found in the urine. By 32P-post-labelling analysis, PhIP-DNA adducts were detected in spleen, lung, heart, kidney, liver and stomach of pups at mean values ranging from 0.06 to 0.55 adducts/107 nucleotides. The large percentage of 4′-hydroxy-PhIP and its conjugates in the urine indicates that 5-day-old pups detoxify PhIP and further metabolize 4′-hydroxy-PhIP obtained from the rat milk. The presence of the glucuronide conjugate of N-hydroxy-PhIP in the urine of pups and the lack of detectable conjugate or N-hydroxylamine itself in rat milk suggest that PhIP from rat milk undergoes metabolic activation via N-hydroxylation in 5-day-old rat pups. This conclusion was further supported by the observation that hepatic S9 fractions from the pups activated PhIP to a mutagen in the Ames Salmonella mutagenicity assay and by the presence of PhIP-DNA adducts in the tissues of the pups. The findings reported here may have carcinogenic and toxicological implications for the infants of women who breast-feed and consume a diet rich in cooked meat.
KW  - amines
KW  - breast feeding
KW  - carcinogens
KW  - heterocyclic nitrogen compounds
KW  - infants
KW  - lactation
KW  - metabolism
KW  - neonates
KW  - rat milk
KW  - sucking
KW  - suckling
KW  - urine
KW  - young animals
KW  - man
KW  - rats
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - newborn infants
KW  - rat lactation
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protein intake and risk of renal cell cancer.
AU  - Chow, W. H.
AU  - Gridley, G.
AU  - McLaughlin, J. K.
AU  - Mandel, J. S.
AU  - Wacholder, S.
AU  - Blot, W. J.
AU  - Niwa, S.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 15
SP  - 1131
EP  - 1139
SN  - 0027-8874
AD  - Chow, W. H.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19951408450.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Human Nutrition
N2  - The role of diet in renal cell cancer risk was examined. Subjects (n=690) were white residents of Minnesota, USA, 20 to 79 years old with histologically confirmed renal cell cancer that had been diagnosed between July 1, 1988 and December 31, 1990. 707 sex-, age- and education-matched controls were selected from the general population of Minnesota. Usual adult dietary intakes were assessed by questionnaire and odds ratios were calculated by logistic regression analyses. Increased risks of renal cell cancer were observed with increasing consumption of several food groups, including red meat (P=0.05), high-protein foods (P=0.01) and staple (grains, breads and potatoes) foods (P=0.009). When examined by macronutrient status, risks increased monotonically with amount of protein intake, from 1.2 (95% confidence interval (CI) = 0.7-1.9) to 1.4 (95% CI = 0.8-2.5) and 1.9 (95% CI = 1.0-3.6) (P=0.03) in the second, third and fourth quartiles of intake, respectively, after adjustment for age, sex, energy intake, body mass index and cigarette smoking. No significant or consistent associations were detected with the intake of other dietary nutrients or beverages. Although an independent effect of dietary protein has not been previously associated with renal cell cancer, high protein consumption has been related to development of other chronic renal conditions that may predispose an individual to this cancer.
KW  - carcinoma
KW  - diet studies
KW  - kidneys
KW  - protein intake
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408450&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer incidence in a population with a high prevalence of infection with human immunodeficiency virus type 1.
AU  - Rabkin, C. S.
AU  - Yellin, F.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1994///
VL  - 86
IS  - 22
SP  - 1711
EP  - 1716
SN  - 0027-8874
AD  - Rabkin, C. S.: National Institutes of Health, EPN/434, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001589.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref.
KW  - Burkitt's lymphoma
KW  - epidemiology
KW  - HIV infections
KW  - Kaposi's sarcoma
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001589&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Meeting on parasites and the invertebrate vector.
AU  - Kaslow, D. C.
AU  - Nussenzweig, V.
AU  - Miller, L.
JO  - Memórias do Instituto Oswaldo Cruz
JF  - Memórias do Instituto Oswaldo Cruz
Y1  - 1994///
VL  - 89
IS  - 2
SP  - 279
EP  - 295
SN  - 0074-0276
AD  - Kaslow, D. C.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950808905.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Registry Number: 9001-67-6.  Subject Subsets: Protozoology
N2  - A meeting on parasites and their invertebrate vectors, held at the John D. and Catherine T. MacArthur Foundation, USA, from November 18-21 1993, discussed insect defence mechanisms; life cycle transitions; changes in surface molecules during host transition stages; interactions of parasites with host extracellular matrix proteins; insect factors in parasite refractoriness; insect factors in mammalian pathogenesis; molecular approaches to understanding the parasite in the vector; the introduction of genes into vector populations; and identification of opportunities for the future. Included among these major topics are communications on trypanosomal trans-sialidases; lipophosphoglycans of Leishmania; chitinase secretion and Leishmania and Plasmodium; pathogenic protozoa; insect saliva and parasite pathogenicity; and the genetic analysis of trypanosome surface glycoprotein function.
KW  - biochemistry
KW  - enzymes
KW  - genes
KW  - host parasite relationships
KW  - immune response
KW  - life cycle
KW  - molecular genetics
KW  - parasites
KW  - pathogenesis
KW  - proteins
KW  - protozoal infections
KW  - sialidase
KW  - surface proteins
KW  - vectors
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - exo-alpha-sialidase
KW  - immunity reactions
KW  - immunological reactions
KW  - membrane proteins
KW  - neuraminidase
KW  - parasite host relationships
KW  - Parasites and the Invertebrate Vector
KW  - protozoal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist.
AU  - Poli, G.
AU  - Kinter, A. L.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 1
SP  - 108
EP  - 112
SN  - 0027-8424
AD  - Poli, G.: Building 10A, Room 6A33A, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028414.  Publication Type: Journal Article.  Language: English. 
KW  - human immunodeficiency viruses
KW  - Immunology
KW  - interleukins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - Monocytic cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide.
AU  - Oswald, I. P.
AU  - Eltoum, I.
AU  - Wynn, T. A.
AU  - Schwartz, B.
AU  - Caspar, P.
AU  - Paulin, D.
AU  - Sher, A.
AU  - James, S. L.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 3
SP  - 999
EP  - 1003
SN  - 0027-8424
AD  - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950808020.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9008-11-1, 308079-78-9.  Subject Subsets: Helminthology
N2  - In vitro exposure of murine endothelial cells to various cytokines (interferon γ, tumour necrosis factor α, or interleukin 1α or 1β) resulted in their activation to kill Schistosoma mansoni schistosomula through an arginine-dependent mechanism involving production of nitric oxide (NO). Cytokine-treated endothelial cells showed increased expression of mRNA for the inducible form of the NO synthase, and both NO production and larval killing were suppressed by treatment with competitive inhibitors. The effector function of cytokine-treated endothelial cells was similar to that of activated inflammatory tissue macrophages, although activation appeared to be differentially regulated in these 2 cell types. Activated endothelial cells killed older (18-day) forms, such as those currently thought to be a primary target of immune elimination in the lungs of mice previously vaccinated with radiation-attenuated cercariae, as well as newly transformed larvae. In C57BL/6 mice, which become resistant to S. mansoni infection as a result of vaccination with irradiated cercariae, endothelial cell morphology characteristic of activation was observed in the lung by 1 to 2 weeks after challenge infection. Similar endothelial cell changes were absent in P-strain mice, which do not become resistant as a result of vaccination. It is considered that endothelial cells, not traditionally considered to be part of the immune system, may play an important role in immunity to S. mansoni and, by means of NO-dependent killing, could serve as effectors of resistance to other intravascular pathogens.
KW  - cytokines
KW  - helminths
KW  - immunity
KW  - interferon
KW  - interleukin 1
KW  - parasites
KW  - tumour necrosis factor
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - cachectin
KW  - cachexin
KW  - endothelial cells
KW  - parasitic worms
KW  - Strigeida
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection.
AU  - Smythe, J. A.
AU  - Sun, D.
AU  - Thomson, M.
AU  - Markham, P. D.
AU  - Reitz, M. S. Jr
AU  - Gallo, R. C.
AU  - Lisziewicz, J.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 9
SP  - 3657
EP  - 3661
SN  - 0027-8424
AD  - Smythe, J. A.: (J. Lisziewicz) Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050759.  Publication Type: Journal Article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - gene therapy
KW  - HIV infections
KW  - molecular biology
KW  - prevention
KW  - treatment
KW  - AIDS
KW  - Gag mutants
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050759&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.
AU  - Lusso, P.
AU  - Secchiero, P.
AU  - Crowley, R. W.
AU  - Garzino-Demo, A.
AU  - Berneman, Z. N.
AU  - Gallo, R. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 9
SP  - 3872
EP  - 3876
SN  - 0027-8424
AD  - Lusso, P.: Laboratory of Tumor Cell Biology,Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050762.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors show that CD4 is a critical component of the cellular membrane receptor of human herpesvirus type 7. CD4+ cells infected with HHV-7 show selective and progressive downregulation of CD4 expression and monoclonal antibodies against CD4 inhibited the HHV-7 infection. Marked reciprocal interference was seen between HHV-7 and HIV. Persistent infection of cells with HIV or contact with gp120 endowed them with resistance to HHV-7 and exposure of cells to HHV-7 reduced infectability of cells with HIV. Studies are now needed of the influence of active HHV-7 on the course of HIV infection. This appears to be the first time that two unrelated viruses have been shown to share the same receptor on susceptible cells. The authors found that monoclonal antibodies to the V1, V2 and V3 domains but not the V4 domain of CD4 all inhibited HHV-7 infection of cells. HHV-7 was unable to infect productively HeLa cells although it bound to their surface membrane.D. W. FitzSimons
KW  - CD4 antigens
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - natural history
KW  - receptors
KW  - resistance
KW  - treatment
KW  - human herpesvirus 7
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - CD4
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth.
AU  - McConkey, G. A.
AU  - Ittarat, I.
AU  - Meshnick, S. R.
AU  - McCutchan, T. F.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 10
SP  - 4244
EP  - 4248
SN  - 0027-8424
AD  - McConkey, G. A.: Molecular Biology Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950806977.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 150-13-0.  Subject Subsets: Protozoology
N2  - Cloned lines of Plasmodium falciparum were isolated that, unlike the parent line from which they were derived, relied on exogenous p-aminobenzoic acid (PABA) for growth. Isolation involved random mutagenesis of a cloned line of P. falciparum and subsequent selection of PABA-dependent parasites. Both parent and PABA-dependent clones were analysed for PABA uptake and synthesis. Each clone took up comparable amounts of PABA from the medium. The parent line, clone 3D7, can synthesize PABA de novo whereas the PABA-dependent clones cannot. The requirement of exogenous PABA for growth by the auxotrophic strains, coupled with their inability to synthesize PABA, indicated that normal parasite growth can be completely supported by either synthesis or salvage. This work further clarified the relationship between the availability of PABA and success of the parasite, an issue of debate from classic studies showing reduced parasite load in individuals on milk-fed diets.
KW  - growth
KW  - malaria
KW  - p-aminobenzoic acid
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - PABA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.
AU  - Boyer, P. L.
AU  - Tantillo, C.
AU  - Jacobo-Molina, A.
AU  - Nanni, R. G.
AU  - Ding, J.
AU  - Arnold, E.
AU  - Hughes, S. H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 11
SP  - 4882
EP  - 4886
SN  - 0027-8424
AD  - Boyer, P. L.: (S. H. Hughes) Advanced BioScience Laboratories-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, PO Box B, Building 539, Frederick MD 21702-1201, USA.
N1  - Accession Number: 19942050773.  Publication Type: Journal Article.  Language: English.  Registry Number: 9068-38-6. 
KW  - antiviral agents
KW  - genomes
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - nucleotide sequences
KW  - resistance
KW  - reverse transcriptase
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA sequences
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.
AU  - Burton, J. D.
AU  - Bamford, R. N.
AU  - Peters, C.
AU  - Grant, A. J.
AU  - Kurys, G.
AU  - Goldman, C. K.
AU  - Brennan, J.
AU  - Roessler, E.
AU  - Waldmann, T. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 11
SP  - 4935
EP  - 4939
SN  - 0027-8424
AD  - Burton, J. D.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008353.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
KW  - interleukins
KW  - lymphokines
KW  - T lymphocytes
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - HTLV-BLV group
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan.
AU  - Pimenta, P. F. P.
AU  - Saraiva, E. M. B.
AU  - Rowton, E.
AU  - Modi, G. B.
AU  - Garraway, L. A.
AU  - Beverley, S. M.
AU  - Turco, S. J.
AU  - Sacks, D. L.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 19
SP  - 9155
EP  - 9159
SN  - 0027-8424
AD  - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, Immunology and Cell Biology Section, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803018.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Comparison of a large number of phlebotomine vector/Leishmania pairs revealed that species-specific differences in vectorial competence were in every case directly correlated with the ability of promastigotes to attach to the sand-fly midgut, the variable outcomes of which were controlled by structural polymorphisms in the surface lipophosphoglycan (LPG) of the parasite. The ability of Phlebotomus papatasi to transmit only Leishmania major could be attributed to the unique, highly substituted nature of L. major LPG that provides for multiple terminally exposed β-linked galactose residues for binding. While the relatively unsubstituted LPGs of other Leishmania species were unable to mediate promastigote attachment to P. papatasi, they could mediate binding to midguts of P. argentipes, which was found to be a potentially competent vector for every Leishmania species examined. It is suggested that at least some phlebotomine vectors differ with respect to the parasite recognition sites which they express and that midgut adhesion is a sufficiently critical component of vectorial competence as to provide the evolutionary drive for LPG structural polymorphisms.
KW  - disease vectors
KW  - lipophosphoglycans
KW  - parasites
KW  - vector competence
KW  - Diptera
KW  - Leishmania
KW  - Leishmania major
KW  - Phlebotominae
KW  - Phlebotomus
KW  - Phlebotomus argentipes
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Psychodidae
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Leishmania
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotominae
KW  - Phlebotomus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.
AU  - Yamanaka, S.
AU  - Johnson, M. D.
AU  - Grinberg, A.
AU  - Westphal, H.
AU  - Crawley, J. N.
AU  - Taniike, M.
AU  - Suzuki, K.
AU  - Proia, R. L.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 21
SP  - 9975
EP  - 9979
SN  - 0027-8424
AD  - Yamanaka, S.: Section on Biochemical Genetics, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950100309.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 9027-52-5.  Subject Subsets: Agricultural Biotechnology
N2  - Tay-Sachs disease, the prototype of the GM2 gangliosidoses, is a catastrophic neurodegenerative disorder of infancy. The disease is caused by mutations in the HEXA gene resulting in an absence of the lysosomal enzyme, β-hexosaminidase A. As a consequence of the enzyme deficiency, GM2 ganglioside accumulates progressively, beginning early in fetal life, to excessive amounts in the central nervous system (CNS). Rapid mental and motor deterioration starting in the 1st year of life leads to death by 2-4 years of age. Through the targeted disruption of the mouse Hexa gene in embryonic stem cells, mice were produced with biochemical and neuropathologic features of Tay-Sachs disease. The mutant mice displayed &lt;1% of normal β-hexosaminidase A activity and accumulated GM2 ganglioside in their CNS in an age-dependent manner. The accumulated ganglioside was stored in neurons as membranous cytoplasmic bodies characteristically found in the neurons of Tay-Sachs disease patients. At 3-5 months of age, the mutant mice showed no apparent defects in motor or memory function. These β-hexosaminidase A-deficient mice should be useful for devising strategies to introduce functional enzyme and genes into the CNS. This model may also be valuable for studying the biochemical and pathologic changes occurring during the course of the disease.
KW  - animal models
KW  - beta-N-acetylhexosaminidase
KW  - biotechnology
KW  - gangliosides
KW  - homologous recombination
KW  - targeted mutagenesis
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hexosaminidase
KW  - Tay-Sachs disease
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Laboratory Animal Science (LL040) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Successful passive and active immunization of cynomolgus monkeys against hepatitis E.
AU  - Tsarev, S. A.
AU  - Tsareva, T. S.
AU  - Emerson, S. U.
AU  - Govindarajan, S.
AU  - Shapiro, M.
AU  - Gerin, J. L.
AU  - Purcell, R. H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 21
SP  - 10198
EP  - 10202
SN  - 0027-8424
AD  - Tsarev, S. A.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007023.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Public Health
KW  - animal models
KW  - hepatitis E
KW  - human diseases
KW  - immunization
KW  - passive immunization
KW  - hepatitis E virus
KW  - man
KW  - monkeys
KW  - Hepatitis E-like viruses
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis.
AU  - Clerici, M.
AU  - Sarin, A.
AU  - Coffman, R. L.
AU  - Wynn, T. A.
AU  - Blatt, S. P.
AU  - Hendrix, C. W.
AU  - Wolf, S. F.
AU  - Shearer, G. M.
AU  - Henkart, P. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1994///
VL  - 91
IS  - 25
SP  - 11811
EP  - 11815
SN  - 0027-8424
AD  - Clerici, M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA..
N1  - Accession Number: 19952006875.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
KW  - apoptosis
KW  - cellular biology
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - interleukins
KW  - pathogenesis
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cell biology
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006875&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biology of the development of Plasmodium in the mosquito midgut: a molecular and cellular view.
AU  - Shahabuddin, M.
AU  - Kaslow, D. C.
JO  - Bulletin de l'Institut Pasteur, France
JF  - Bulletin de l'Institut Pasteur, France
Y1  - 1994///
VL  - 92
IS  - 2
SP  - 119
EP  - 132
SN  - 0020-2452
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950810690.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Number of References: 64 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The biology of the development of Plasmodium in the mosquito midgut is reviewed from a molecular and cellular viewpoint under the following headings: sporogonic development of Plasmodium in the mosquito vector (emergence from erythrocytes; exflagellation; fertilization; development of zygote to ookinete); the peritrophic matrix; Plasmodium and mosquito PM [peritrophic matrix].
KW  - development
KW  - developmental stages
KW  - disease vectors
KW  - life history
KW  - malaria
KW  - midgut
KW  - molecular biology
KW  - parasites
KW  - reviews
KW  - vectors
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - growth phase
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men.
AU  - Castillo, C.
AU  - Bogardus, C.
AU  - Bergman, R.
AU  - Thuillez, P.
AU  - Lillioja, S.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1994///
VL  - 93
IS  - 1
SP  - 10
EP  - 16
SN  - 0021-9738
AD  - Castillo, C.: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19951410568.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Registry Number: 50-99-7, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Insulin action and obesity are correlated with the density of muscle capillary supply in man. Since the altered muscle anatomy in the obese might affect interstitial insulin concentrations and reduce insulin action, peripheral lymphatic vessels were cannulated in lean and obese men (21.2 to 36.6 years old) and peripheral lymph insulin concentrations were compared with whole body glucose uptake during a euglycaemic, hyperinsulinaemic clamp. Lymph insulin concentrations in the lower limb averaged only 34% of arterial insulin concentrations during 150 min of insulin infusion. Obese subjects had the highest arterial (P≤0.0001) and lymph insulin (P&lt;0.005) concentrations, but the lowest glucose uptake rates (P&lt;0.002). In contrast to the initial steep increase then plateau of arterial insulins, lymph insulin and whole body glucose uptake rates increased slowly and did not consistently reach a plateau. In each individual, the glucose uptake closely correlated with peripheral lymphatic insulin concentrations (mean r² = 0.95). The coupling between glucose uptake and lymph insulin (glucose uptake/pmol insulin) was much steeper in lean subjects than in the obese (P≤0.0001). These results indicate that even if insulin diffusion into tissues is rate limiting for insulin action, a tissue defect rather than an insulin diffusion defect causes insulin resistance in obese subjects.
KW  - glucose
KW  - insulin
KW  - lymph
KW  - men
KW  - obesity
KW  - uptake
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dextrose
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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TY  - JOUR
T1  - The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate.
AU  - Rader, D. J.
AU  - Cain, W.
AU  - Ikewaki, K.
AU  - Talley, G.
AU  - Zech, L. A.
AU  - Usher, D.
AU  - Brewer, H. B., Jr.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1994///
VL  - 93
IS  - 6
SP  - 2758
EP  - 2763
SN  - 0021-9738
AD  - Rader, D. J.: Molecular Disease Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951408107.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - Lipoprotein(a) (Lp[a]) is an atherogenic lipoprotein which is similar in structure to LDL but contains an additional protein called apolipoprotein(a) (apo[a]). Apo(a) is highly polymorphic in size, and there is a strong inverse association between the size of the apo(a) isoform and the plasma concentration of Lp(a). In vivo catabolism of Lp(a) particles containing different size apo(a) isoforms were compared to establish whether there is an effect of apo(a) isoform size on the catabolic rate of Lp(a). In the first series of studies, 4 normal subjects were injected with radiolabelled S1-Lp(a) and S2-Lp(a) and another 4 were injected with radiolabelled S2-Lp(a) and S4-Lp(a). No significant differences in fractional catabolic rate were found between Lp(a) particles containing different apo(a) isoforms. To confirm that apo(a) isoform size does not influence the rate of Lp(a) catabolism, 3 subjects heterozygous for apo(a) were selected for preparative isolation of both Lp(a) particles. The first was a B/S3-apo(a) subject, the second a S4/S6-apo(a) subject and the third an F/S3-apo(a) subject. From each subject, both Lp(a) particles were preparatively isolated, radiolabelled and injected into donor subjects and normal volunteers. In all cases, the catabolic rates of the 2 forms of Lp(a) were not significantly different. In contrast, the allele-specific apo(a) production rates were more than twice as great for the smaller apo(a) isoforms than for the larger apo(a) isoforms. In 17 studies directly comparing Lp(a) particles of different apo(a) isoform size, the mean fractional catabolic rate of the Lp(a) with smaller size apo(a) was 0.329±0.090 day-1 and of the Lp(a) with the larger size apo(a) 0.306±0.079 day-1, not significantly different. In summary, the inverse association of plasma Lp(a) concentrations with apo(a) isoform size is not due to differences in the catabolic rates of Lp(a) but rather to differences in Lp(a) production rates.
KW  - apolipoproteins
KW  - blood
KW  - catabolism
KW  - kinetics
KW  - lipid metabolism
KW  - lipoproteins
KW  - metabolism
KW  - size
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fat metabolism
KW  - Physiology of Human Nutrition (VV120) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Lipid levels in adults with cystic fibrosis.
AU  - Slesinski, M. J.
AU  - Gloninger, M. F.
AU  - Costantino, J. P.
AU  - Orenstein, D. M.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1994///
VL  - 94
IS  - 4
SP  - 402
EP  - 408
SN  - 0002-8223
AD  - Slesinski, M. J.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951401402.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The hypothesis that an energy-dense, high-fat diet, which is necessary to maintain weight in adults with cystic fibrosis, does not result in high serum cholesterol concentrations was tested. Dietary, anthropometric and biochemical data from 31 adults with cystic fibrosis, 50 obligate carriers of the cystic fibrosis gene, and 26 controls who did not have cystic fibrosis were correlated at a cystic fibrosis centre in Pittsburgh, USA. Adults with cystic fibrosis had a lower mean serum cholesterol concentration and higher mean intakes of energy and fat than controls. Univariate correlation coefficients were estimated to measure the relative intensity of association between 2 variables. Mean total serum cholesterol concentrations in men with cystic fibrosis and male controls was 3.1 and 4.7 mmol/litre, respectively (P&lt;0.001). Mean total serum cholesterol concentrations in women with cystic fibrosis was 3.2 compared with 4.3 mmol/litre in female controls (P&lt;0.001). 3 adults with cystic fibrosis and no signs of pancreatic insufficiency had serum cholesterol concentrations in the high normal range. Carriers had serum lipid concentrations in the same range as controls. The findings indicate that a high-energy, high-fat diet does not increase serum lipid concentrations in those patients with cystic fibrosis and pancreatic insufficiency. However, those individuals with cystic fibrosis and normal pancreatic function may be at the same risk as the general population for developing high serum lipid concentrations. They should have their serum lipid concentrations monitored and be given appropriate dietary recommendations.
KW  - adults
KW  - blood lipids
KW  - cholesterol
KW  - cystic fibrosis
KW  - diet treatment
KW  - energy intake
KW  - fats
KW  - intake
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - diet prescription
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor: a novel strategy for the therapy of KS.
AU  - Ensoli, B.
AU  - Markham, P.
AU  - Kao, V.
AU  - Barillari, G.
AU  - Fiorelli, V.
AU  - Gendelman, R.
AU  - Raffeld, M.
AU  - Zon, G.
AU  - Gallo, R. C.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1994///
VL  - 94
IS  - 5
SP  - 1736
EP  - 1746
SN  - 0021-9738
AD  - Ensoli, B.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6A09, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001599.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
KW  - acquired immune deficiency syndrome
KW  - angiogenesis
KW  - human diseases
KW  - inhibition
KW  - Kaposi's sarcoma
KW  - pathogenesis
KW  - treatment
KW  - AIDS
KW  - antisense oligonucleotides
KW  - fibroblast growth factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001599&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutritional prediction of pressure ulcers.
AU  - Breslow, R. A.
AU  - Bergstrom, N.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1994///
VL  - 94
IS  - 11
SP  - 1301
EP  - 1304
SN  - 0002-8223
AD  - Breslow, R. A.: National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA.
N1  - Accession Number: 19951402287.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - This article focuses on nutritional risk factors that predict the development of pressure ulcers in hospital and nursing home patients. Cross-sectional studies associate inadequate energy and protein intake; underweight; low triceps skinfold measurement; and low serum albumin, serum cholesterol and haemoglobin values with pressure ulcers. Prospective studies identify inadequate energy and protein intake, a poor score on the Braden scale (a risk assessment instrument that includes a nutrition component) and possibly low serum albumin as risk factors for developing a pressure ulcer. Nutritionists should provide a high-energy, high-protein diet for patients at risk of development of pressure ulcers to improve their dietary intake and nutritional state.
KW  - anthropometric dimensions
KW  - blood
KW  - cholesterol
KW  - diet
KW  - energy intake
KW  - haemoglobin
KW  - nutritional state
KW  - protein intake
KW  - risk
KW  - serum albumin
KW  - ulcers
KW  - underweight
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anthropometric measurements
KW  - hemoglobin
KW  - nutritional status
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gravidity, obesity,and non-insulin-dependent diabetes among Pima Indian women.
AU  - Charles, M. A.
AU  - Pettitt, D. J.
AU  - McCance, D. R.
AU  - Hanson, R. L.
AU  - Bennett, P. H.
AU  - Knowler, W. C.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1994///
VL  - 97
IS  - 3
SP  - 250
EP  - 255
SN  - 0002-9343
AD  - Charles, M. A.: National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, Arizona 85014, USA.
N1  - Accession Number: 19951407790.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - A study was conducted to evaluate the relationship among gravidity, obesity and non-insulin-dependent diabetes mellitus (NIDDM) in 2779 Pima Indian women. Prevalence of NIDDM was higher among women who had never been pregnant than among those who had been pregnant (age- and obesity-adjusted odds ratio = 2.0; 95% confidence interval (CI) = 1.5 to 2.7). Controlled for age and obesity, nondiabetic women who had never been pregnant had higher fasting plasma glucose concentrations by 2% (P=0.004), higher fasting serum insulin concentrations by 8% (P=0.09) and higher 2-h serum insulin concentrations by 10% (P=0.07) than nondiabetic women who had been pregnant. Among 1025 women observed for an average of 8 years, those who had not been pregnant by the baseline examination were at significantly higher risk for developing NIDDM before 40 years old (incidence rate ratio = 1.5; 95% CI = 1.2 to 2.1), but that difference could be accounted for by a higher degree of obesity. It is hypothesized that Pima Indian women who have a high risk for NIDDM develop obesity and hyperinsulinaemia at an early age, and that may be responsible for decreased fertility because of associated changes in sex hormones.
KW  - diabetes
KW  - ethnic groups
KW  - fertility
KW  - obesity
KW  - pregnancy
KW  - risk
KW  - risk factors
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - gestation
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - NO as an effector molecule of parasite killing: modulation of its synthesis by cytokines.
AU  - Oswald, I. P.
AU  - Wynn, T. A.
AU  - Sher, A.
AU  - James, S. L.
JO  - Comparative Biochemistry and Physiology. C, Pharmacology, Toxicology & Endocrinology
JF  - Comparative Biochemistry and Physiology. C, Pharmacology, Toxicology & Endocrinology
Y1  - 1994///
VL  - 108
IS  - 1
SP  - 11
EP  - 18
SN  - 0742-8413
AD  - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950801247.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Registry Number: 76057-06-2, 9008-11-1, 10102-43-9.  Subject Subsets: Protozoology; Helminthology
N2  - This review considers the role of nitric oxide (NO) as a major effector molecule of macrophage cytotoxicity against a variety of microbial targets, including protozoan and helminth parasites. NO production by macrophages is arginine dependent and catalyzed by a cytokine-inducible form of the NO synthase. This activity is positively controlled by several up-regulatory stimuli (including interferon-γ, tumour necrosis factor-α and interleukin (IL)-2) and negatively controlled by others (principally IL-10, IL-4 and transforming growth factor-β). Other cell types, such as endothelial cells and hepatocytes, display a similar capacity for NO production in response to cytokine stimulation. In murine models of leishmaniasis and schistosomiasis, in vivo NO synthesis correlates with protective immunity against infection.
KW  - cytokines
KW  - endothelium
KW  - helminths
KW  - immune response
KW  - interferon
KW  - interleukins
KW  - liver cells
KW  - macrophages
KW  - nitric oxide
KW  - parasites
KW  - reviews
KW  - transforming growth factor
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - hepatocytes
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of the lipophosphoglycan of Leishmania in vector competence.
AU  - Sacks, D. L.
AU  - Saraiva, E. M.
AU  - Rowton, E.
AU  - Turco, S. J.
AU  - Pimenta, P. F.
A2  - Smith, J. E.
A2  - Chappell, L. H.
JO  - Parasitology
JF  - Parasitology
Y1  - 1994///
VL  - 108
SP  - S55
EP  - S62
SN  - 0031-1820
AD  - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950800683.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 42 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The surface lipophosphoglycans (LPG) of Leishmania promastigotes express stage- and species-specific polymorphisms that are defined by variations in the type and number of phosphorylated oligosaccharide repeats. The way in which these polymorphic structures control the development of transmissible infections in the sandfly vector as well as the species-specificity of vectorial competence was studied in Phlebotomus papatasi, P. argentipes and Lutzomyia longipalpis. Procyclic promastigotes displayed an inherent capacity to bind to midgut epithelial cells of a competent vector. This capacity was lost during their transformation to metacyclic promastigotes, permitting the selective release and anterior migration of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release were found to be controlled by developmental modifications in terminally exposed saccharides on LPG, which, depending on the species of Leishmania, involved either substitution or capping of terminal side-chain sugars, loss of terminal side-chain sugars, substitution or loss of neutral capping sugars. The stage-specific terminal sugars involved in midgut adhesion are, in some cases, also species-specific, and the extent to which these differences affect midgut attachment, forcefully predicted vectorial competence.
KW  - disease vectors
KW  - host parasite relationships
KW  - human diseases
KW  - leishmaniasis
KW  - lipophosphoglycans
KW  - parasites
KW  - promastigotes
KW  - vector competence
KW  - vector-borne diseases
KW  - Diptera
KW  - Leishmania
KW  - Lutzomyia longipalpis
KW  - Phlebotominae
KW  - Phlebotomus argentipes
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Psychodidae
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Lutzomyia
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - leishmaniosis
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Misdiagnosed HIV infection in pregnant women: implications for clinical care.
AU  - Sheon, A. R.
AU  - Fox, H. E.
AU  - Alexander, G.
AU  - Buck, A.
AU  - Higgins, A.
AU  - McDermott, S. M.
AU  - Moroso, G.
AU  - Moye, J.
AU  - Pacheco-Acosta, E.
JO  - Public Health Reports
JF  - Public Health Reports
Y1  - 1994///
VL  - 109
IS  - 5
SP  - 694
EP  - 699
SN  - 0033-3549
AD  - Sheon, A. R.: Divison of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Rockville, MD 20892, USA.
N1  - Accession Number: 19952001094.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref.
KW  - antibody testing
KW  - HIV infections
KW  - human diseases
KW  - maternal transmission
KW  - misdiagnosis
KW  - pregnancy
KW  - serology
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antibody detection
KW  - antibody tests
KW  - gestation
KW  - human immunodeficiency virus infections
KW  - mother to child transmission
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Social and legal factors related to drug abuse in the United States and Japan.
AU  - Greberman, S. B.
AU  - Wada, K.
JO  - Public Health Reports
JF  - Public Health Reports
Y1  - 1994///
VL  - 109
IS  - 6
SP  - 731
EP  - 737
SN  - 0033-3549
AD  - Greberman, S. B.: National Institute on Drug Abuse Addiction Research Center, Treatment Branch, P.O. Box 5180, Baltimore, MD 21224, USA.
N1  - Accession Number: 19952010526.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - An overview.
KW  - drug abuse
KW  - human diseases
KW  - law
KW  - reviews
KW  - sociology
KW  - Asia
KW  - Japan
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - America
KW  - North America
KW  - drug use
KW  - legal aspects
KW  - legal principles
KW  - social aspects
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Laws and Regulations (DD500) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Postoperative complications in patients receiving suramin therapy.
AU  - Cole, D.
AU  - Ettinghausen, S. E.
AU  - Pass, H. I.
AU  - Danforth, D. N.
AU  - Linehan, M. W.
AU  - Myers, C. W.
AU  - Cooper, M. R.
AU  - Sindelar, W. F.
JO  - Surgery
JF  - Surgery
Y1  - 1994///
VL  - 116
IS  - 1
SP  - 90
EP  - 95
SN  - 0039-6060
AD  - Cole, D.: Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10 Room 2B42, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940804357.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 145-63-1.  Subject Subsets: Protozoology; Helminthology
KW  - adverse effects
KW  - antiprotozoal agents
KW  - helminths
KW  - parasites
KW  - suramin
KW  - surgery
KW  - toxicity
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - adverse reactions
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Diagnosis of ocular toxoplasmosis by the use of immunocytology and the polymerase chain reaction.
AU  - Chan, C. C.
AU  - Palestine, A. G.
AU  - Li, Q.
AU  - Nussenblatt, R. B.
T2  - American Journal of Ophthalmology
JO  - American Journal of Ophthalmology
JF  - American Journal of Ophthalmology
Y1  - 1994///
VL  - 117
IS  - 6
SP  - 803
EP  - 805
SN  - 0002-9394
AD  - Chan, C. C.: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805019.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Subject Subsets: Protozoology
N2  - The use of polymerase chain reaction (PCR), for amplification of the 35-fold repetitive B1 gene of Toxoplasma gondii, in the diagnosis of ocular toxoplasmosis is reported. A 61-year-old man with an 18 year history of chronic lymphocytic leukaemia presented with deterioration of vision in the left eye. Routine investigations failed to find a convincing cause of his retinitis. A diagnostic vitrectomy was performed and PCR identified T. gondii. Subsequent post mortem examination provided further material and, using PCR, only sections through the ocular lesion were positive for T. gondii. In this patient, the phenotype of the infiltrating cells found in the left eye proved critical for the diagnosis and to help guide therapy.
KW  - case reports
KW  - human diseases
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - retinitis
KW  - toxoplasmosis
KW  - USA
KW  - Apicomplexa
KW  - man
KW  - protozoa
KW  - Sarcocystidae
KW  - Toxoplasma gondii
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nucleotide sequence and analysis of the gene in Borrelia burgdorferi encoding the immunogenic P39 antigen.
AU  - Simpson, W. J.
AU  - Cieplak, W.
AU  - Schrumpf, M. E.
AU  - Barbour, A. G.
AU  - Schwan, T. G.
JO  - FEMS Microbiology Letters
JF  - FEMS Microbiology Letters
Y1  - 1994///
VL  - 119
IS  - 3
SP  - 381
EP  - 388
SN  - 0378-1097
AD  - Simpson, W. J.: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19960500232.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The P39 antigen is a specific, highly conserved and immunogenic protein of B. burgdorferi s.l. The nucleotide sequence of the gene encoding this protein was determined and found to be the first of 2 tandemly arranged open reading frames (ORFs) located on the spirochaete's chromosome. These 2 ORFs were designated bmpA for the gene encoding P39 and bmpB for the gene encoding the putative protein ORF2 encoded by the 2nd ORF. The nucleic acid sequence identity for the 2 ORFs was 62%, while their deduced amino acid sequences were 52% identical. Comparison to sequence databases demonstrated that the deduced amino acid sequences of both P39 and ORF2 were homologous to TmpC, a putative outer or cytoplasmic lipoprotein of Treponema pallidum.
KW  - amino acid sequences
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - proteins
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500232&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats.
AU  - Davis, C. D.
AU  - Farb, A.
AU  - Thorgeirsson, S. S.
AU  - Virmani, R.
AU  - Synderwine, E. G.
JO  - Toxicology and Applied Pharmacology
JF  - Toxicology and Applied Pharmacology
Y1  - 1994///
VL  - 124
IS  - 2
SP  - 201
EP  - 211
SN  - 0041-008X
AD  - Davis, C. D.: Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19941405664.  Publication Type: Journal Article.  Language: English.  Number of References: 37 refs. Subject Subsets: Human Nutrition
N2  - Cooked meat contains a number of mutagenic/carcinogenic heterocyclic amines, including 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP). Monkeys treated with IQ show myocyte degeneration and mitochondrial changes. To develop models to investigate heterocyclic amine cardiotoxicity, primary cultures of foetal rat myocytes were exposed to the activated forms of the carcinogens (N-OH-IQ and N-OH-PhIP). Lactate dehydrogenase leakage increased in proportion to carcinogen dose but was significantly greater in cells exposed to N-OH-IQ than that in cells exposed to N-OH-PhIP. Electron microscopy revealed that treated cells had swollen and irregular mitochondria and fewer organelles. However, DNA adducts, assessed using the 32P-postlabelling method, were significantly higher in myocytes exposed to N-OH-PhIP than in cells exposed to N-OH-IQ. The toxic effects of heterocyclic amines were also evaluated in rats given IQ or PhIP (100 mg/kg, by mouth 10 doses during 2 weeks). Light microscopic and ultra-structural cardiac abnormalities were present in 7 of 8 rats exposed to IQ or PhIP. Whereas controls had a normal cardiac morphology, carcinogen-treated rats had foci of chronic inflammation with myocyte necrosis, myofibrillar dissolution and disarray, and dilation of T-tubules. The results suggest that, in addition to be carcinogenic, food mutagens may play a role in cardiac degeneration.
KW  - amines
KW  - cell cultures
KW  - foods
KW  - heart
KW  - heterocyclic nitrogen compounds
KW  - muscles
KW  - mutagenesis
KW  - mutagenicity
KW  - mutagens
KW  - toxicity
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Determination of fractional absorption of dietary calcium in humans.
AU  - Yergey, A. L.
AU  - Abrams, S. A.
AU  - Vieira, N. E.
AU  - Aldroubi, A.
AU  - Marini, J.
AU  - Sidbury, J. B.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1994///
VL  - 124
IS  - 5
SP  - 674
EP  - 682
SN  - 0022-3166
AD  - Yergey, A. L.: National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941407064.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Human Nutrition
N2  - 4 dual-isotopic label methods for estimating true fractional absorption of dietary calcium were compared in normal subjects (including pregnant and lactating women and children), adults with osteoporosis secondary to glycogen storage disease and patients with osteogenesis imperfecta. The ratio of the integrals of oral label in a 24-h pooled urine to intravenous label in the same urine (α24h) was taken as the standard against which the others were compared. αSpot was the ratio of the fraction of oral label to the fraction of intravenous label in a single urine specimen; αLag was the ratio of the value of oral label in blood 4 h after administration to the value of intravenous label in blood 2 h after administration. αDec was obtained by deconvoluting response to the intravenous label from the response to the oral tracer. Results were as follows: α24h = 0.273±0.124, αDec = 0.300±0.101 (n=14), αSpot = 0.359±0.179 and αLag = 0.271±0.103. The Bland-Altman approach for comparison of methods was used to show that results for αSpot and αLag can be expected, with a 95% confidence limit, to differ from the value of α24h by 60 and 69%, respectively. The results for αDec were shown to be not only indistinguishable from α24h but identical from a theoretical perspective.
KW  - bone diseases
KW  - bone formation
KW  - calcium absorption
KW  - comparisons
KW  - estimation
KW  - glycogenosis
KW  - isotopes
KW  - metabolic disorders
KW  - methodology
KW  - osteogenesis imperfecta
KW  - osteoporosis
KW  - tracer techniques
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bone calcification
KW  - brittle bone disease
KW  - glycogen disease
KW  - glycogen storage disease
KW  - glycogenic hepatomegaly
KW  - metabolic diseases
KW  - methods
KW  - Pompe's disease
KW  - Von Gierke's disease
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Chemistry (ZZ600) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary assessment resource manual.
AU  - Thompson, F. E.
AU  - Byers, T.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1994///
VL  - 124
IS  - 11, SUP
SP  - 2245S
EP  - 2317S
SN  - 0022-3166
AD  - Thompson, F. E.: National Cancer Institute, Division of Cancer Prevention and Control, Applied Research Branch, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19951400129.  Publication Type: Journal Article.  Language: English.  Number of References: 234 ref. Subject Subsets: Human Nutrition
N2  - This manual is intended to help nutritionists and others involved in assessing diet. It provides a brief description and critical evaluation of common dietary assessment methods, advice on choosing the most appropriate method for various designs, a discussion of issues to be considered when assessing diet, examples of specific assessment tools and a list of reviews and publications on dietary assessments.
KW  - assessment
KW  - diet
KW  - diet study techniques
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gianotti-Crosti syndrome and human immunodeficiency virus infection.
AU  - Blauvelt, A.
AU  - Turner, M. L.
JO  - Archives of Dermatology
JF  - Archives of Dermatology
Y1  - 1994///
VL  - 130
IS  - 4
SP  - 481
EP  - 483
SN  - 0003-987X
AD  - Blauvelt, A.: (M.L. Turner) Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006225.  Publication Type: Journal Article.  Language: English. 
KW  - Children
KW  - Dermatology
KW  - Hepatitis C
KW  - HIV infections
KW  - lesions
KW  - skin
KW  - skin lesions
KW  - Cytomegalovirus
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium avium complex
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - bacterium
KW  - dermis
KW  - Gianotti-Crosti syndrome
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006225&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for an in vivo role of insulin-like growth factor-binding protein-1 and -2 as inhibitors of collagen gene expression in vitamin C-deficient and fasted guinea pigs.
AU  - Gosiewska, A.
AU  - Wilson, S.
AU  - Kwon, D.
AU  - Peterkofsky, B.
JO  - Endocrinology (Philadelphia)
JF  - Endocrinology (Philadelphia)
Y1  - 1994///
VL  - 134
IS  - 3
SP  - 1329
EP  - 1339
SN  - 0013-7227
AD  - Gosiewska, A.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19941412483.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 50-81-7, 61912-98-9.  Subject Subsets: Human Nutrition
N2  - The kinetics of induction of insulin-like growth factor-binding protein-1 and -2 (IGFBP-1 and -2) relative to suppression of collagen gene expression was investigated. Guinea pigs were fasted for 10 to 96 h, with 3 to 24% weight loss, or received an ascorbate-free diet for up to 4 weeks, with 5 to 28% weight loss during the third and fourth weeks (phase II of scurvy). In both deficiencies, there was noncoordinate regulation of collagen mRNA expression in tissues. Type I collagen mRNA concentrations in skin decreased rapidly after 5 to 10% weight loss and reached about 10% of normal values, whereas in bone, there was a later, and not as extensive, decrease. The concentration of cartilage type II collagen mRNA decreased rapidly initially, but then remained at 40 to 50% of normal. Circulating insulin-like growth factor I (IGF-I) concentrations remained normal during the period when collagen gene expression was initially suppressed, although there was a later decrease. In contrast, mRNAs for IGFBP-1 and -2 and the circulating proteins were induced before or concomitantly with the suppression of collagen gene expression. The ability of fasted or scorbutic guinea pig sera to inhibit IGF-I action in cells increased in parallel with IGFBP activity ([125I]IGF-I binding), which, in turn, mainly reflected the concentration of IGFBP-1 in sera. Serum insulin may be the primary regulator of the IGFBPs. Its values were decreased to 10 to 13% of normal when weight loss commenced, whereas cortisol values, although increased, did not correlate with the induction of IGFBPs. The overall results taken together with recent findings from cell culture experiments are compatible with circulating IGFBP-1 and -2 acting as inhibitors of collagen gene expression by blocking IGF-I action during fasting and phase II of vitamin C deficiency.
KW  - ascorbic acid
KW  - binding proteins
KW  - collagen
KW  - deficiency
KW  - gene expression
KW  - inhibition
KW  - insulin-like growth factor
KW  - vitamins
KW  - guineapigs
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - guinea pigs
KW  - somatomedin C
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy adjustment methods for nutritional epidemiology: the effect of categorization.
AU  - Brown, C. C.
AU  - Kipnis, V.
AU  - Freedman, L. S.
AU  - Hartman, A. M.
AU  - Schatzkin, A.
AU  - Wacholder, S.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1994///
VL  - 139
IS  - 3
SP  - 323
EP  - 338
SN  - 0002-9262
AD  - Brown, C. C.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951400966.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Human Nutrition
N2  - The interpretation of 4 alternative energy adjustment methods (Residual, Standard, Partition and Nutrient Density) that have been proposed for the analysis of nutritional epidemiology studies was examined. These methods have so far been compared under circumstances where intake of the nutrient of interest is measured as a continuous variable. Because it is common practice to categorize nutrient intakes in the analysis, the authors investigate the effect of such categorization on the interpretation of results from the 4 methods with the use of computer simulations and statistical theory. They consider 4 cases: where the nutrient intake is divided into quartiles or ordered so as to investigate trend over the quartile groups, combined with using an adjusting variable that is continuous or categorized. The results show: Residual, Standard and Partition methods are no longer equivalent as they are in the continuous case; compared with the Standard method, the Residual method appears to be more powerful for detecting trends in relative odds, is more robust to residual confounding when the adjustment variable is categorized, and provides more meaningful odds ratios; and the Residual and Nutrient Density methods give closely similar results.
KW  - assessment
KW  - diet study techniques
KW  - epidemiology
KW  - methodology
KW  - models
KW  - nutrition
KW  - statistics
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - methods
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400966&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome.
AU  - Biggar, R. J.
AU  - Curtis, R. E.
AU  - Cote, T. R.
AU  - Rabkin, C. S.
AU  - Melbye, M.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1994///
VL  - 139
IS  - 4
SP  - 362
EP  - 368
SN  - 0002-9262
AD  - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 434, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19942006081.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - HIV infections
KW  - Kaposi's sarcoma
KW  - Neoplasms
KW  - Non-Hodgkin's lymphoma
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - cancers
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006081&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Physical activity and risk of breast cancer in the Framingham Heart Study.
AU  - Dorgan, J. F.
AU  - Brown, C.
AU  - et al.
AU  - Barrett, M. (
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1994///
VL  - 139
IS  - 7
SP  - 662
EP  - 669
SN  - 0002-9262
AD  - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, EPN, Room 211, 6130 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19942028515.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors analysed data from the Framingham Heart Study [in the USA] to evaluate the association between physical activity and breast cancer risk. Physical activity was ascertained by a physician-administered questionnaire from 2321 women at the fourth biennial examination conducted in 1954-1956. Breast cancers were identified by self-report, surveillance of admissions to Framingham Union Hospital, and review of death records; all but one were histologically confirmed. During 28 years of follow-up, 117 breast cancer cases were diagnosed among the 2307 women with data on physical activity and reproductive history (a potential confounder). Analysis was performed using Cox proportional hazards models with age as the underlying time variable. Models were adjusted for age at physical activity assessment, menopausal status, age at first pregnancy, parity, education, occupation, and alcohol ingestion. [The authors] observed a gradient of increasing risk of breast cancer with increasing physical activity (trend P = 0.06). The relative risk for women in the highest vs. lowest activity quartile was 1.6 (95% confidence interval 0.9-3.0; P = 0.13). Although both moderate-to-heavy leisure and occupational activities were associated with an increased risk, the association was marginally significant only for leisure activity (P = 0.06). [The authors'] findings do not support a protective effect of physical activity during adulthood for breast cancer, but suggest an increased risk among more active women.AS
KW  - breast
KW  - neoplasms
KW  - physical activity
KW  - risk factors
KW  - North America
KW  - USA
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028515&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of the electrophoretic karyotypes and chromosomal location of ten genes in the two varieties of Cryptococcus neoformans.
AU  - Wickes, B. L.
AU  - Moore, T. D. E.
AU  - Kwon-Chung, K. J.
JO  - Microbiology (Reading)
JF  - Microbiology (Reading)
Y1  - 1994///
VL  - 140
IS  - 3
SP  - 543
EP  - 550
SN  - 1350-0872
AD  - Wickes, B. L.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201196.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Multiple isolates of C. neoformans var. neoformans and C. neoformans var. gattii, as well as previously characterized representative isolates, were compared for their electrophoretic karyotypes using pulsed-field electrophoresis. The 2 varieties could be clearly distinguished based upon the size of the smallest chromosome. The smallest chromosome for isolates of the gattii variety (serotypes B and C) was 400-700 kb in size. The smallest chromosome for isolates of the neoformans variety was consistently larger, approx. 770 kb in size. Isolates of the gattii variety averaged 13 chromosomes while the neoformans variety averaged 12. The size of the Cryptococcus genome was approx. 23 megabases. With regard to gene position, isolates of C. neoformans var. neoformans tended to be more conserved than those of var. gattii.
KW  - electrophoresis
KW  - genetics
KW  - karyotypes
KW  - Cryptococcus gattii
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus neoformans
KW  - Cryptococcus neoformans var. gattii
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201196&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Maternal smoking during lactation: relation to infant size at one year of age.
AU  - Little, R. E.
AU  - Lambert, M. D., III
AU  - Worthington-Roberts, B.
AU  - Ervin, C. H.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1994///
VL  - 140
IS  - 6
SP  - 544
EP  - 554
SN  - 0002-9262
AD  - Little, R. E.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
N1  - Accession Number: 19950400489.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - This study was conducted to test the hypothesis that breast-fed infants of smokers are smaller in size at 1 year of age than breast-fed infants of non-smokers. Three groups of infants were selected from all singletons born to women who were seen for prenatal care in their 6th month of pregnancy at a health maintenance organization in Seattle, Washington, USA, between Jan. 1982 and April 1983. Breast-fed infants of smokers (n = 74) were compared with breast-fed infants of non-smokers (n = 195) and with bottle-fed infants of smokers (n = 64). Mothers were interviewed at 1 and 3 months after delivery; both the mother and the infant were seen at 1 year. Among breast feeders, smokers' infants were twice as likely as non-smokers' infants to have body weight &gt;1 s.d. above the mean (relative risk = 2.04, 95% confidence interval 1.15-3.61). This relationship persisted after control for gestational age and weight at birth, length of lactation, mother's size and diet, exposure to other drugs in human milk, and all other variables measured in this study. Every 10 cigarettes smoked while breast-feeding predicted an additional 3% infant body weight at 1 year. In summary, breast-fed infants of smokers in this study gained more weight after birth than the other 2 groups; at 1 year of age, they were heavier and had significantly higher body weight.
KW  - body weight
KW  - breast feeding
KW  - growth
KW  - infants
KW  - lactation
KW  - liveweight gain
KW  - tobacco smoking
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human lactation
KW  - liveweight gains
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
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TY  - JOUR
T1  - Moderate low birth weight and infectious disease mortality during infancy and childhood.
AU  - Read, J. S.
AU  - Clemens, J. D.
AU  - Klebanoff, M. A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1994///
VL  - 140
IS  - 8
SP  - 721
EP  - 733
SN  - 0002-9262
AD  - Read, J. S.: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
N1  - Accession Number: 19952001489.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Public Health
N2  - The purpose of this study was to determine whether moderately low birth weight, singleton babies without congenital anomalies are at increased risk for postperinatal infectious disease mortality. The study cohort consisted of 54 795 live births assembled at 12 medical school-affiliated hospitals in different regions of the United States between 1959 and 1966 and followed prospectively. After exclusions of multiple gestation births, very low birth weight (less than 1500 g) births, births with major congenital anomalies, and first-week deaths, 51 931 children remained for analysis. Postperinatal infectious disease mortality was assessed through age 7 years. Causes of death were classified independently by two pediatricians, blinded to birth weight status, according to an algorithm developed for the study. Moderately low birth weight infants and children were at increased risk of infectious disease mortality (relative risk (RR) = 2.49, 95% confidence interval (CI) 1.74-3.55). The risk persisted among those whose deaths met the authors' strictest criteria for infectious aetiology and was sustained beyond infancy throughout the age interval under analysis. Among those with moderate low birth weight, there was an increased risk among those with preterm birth (RR = 2.77, 95% CI 1.19-6.46) but not among those who were born small-for-gestational age (RR = 1.19, 95% CI 0.37-3.83). The data suggest that moderate low birth weight renders individuals vulnerable to infectious disease mortality during both infancy and childhood. Among moderately low birth weight infants and children, this vulnerability appeared to be attributable primarily to preterm birth rather than to intrauterine growth retardation.
KW  - birth weight
KW  - children
KW  - human diseases
KW  - infant mortality
KW  - infants
KW  - infectious diseases
KW  - low birth weight infants
KW  - mortality
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - communicable diseases
KW  - death rate
KW  - United States of America
KW  - Demography (UU200) 
KW  - Human Fertility (UU250) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins.
AU  - Margolis, N.
AU  - Hogan, D.
AU  - Cieplak, W., Jr.
AU  - Schwan, T. G.
AU  - Rosa, P. A.
JO  - Gene
JF  - Gene
Y1  - 1994///
VL  - 143
IS  - 1
SP  - 105
EP  - 110
SN  - 0378-1119
AD  - Margolis, N.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950504927.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Synthesis of the B. burgdorferi outer surface protein C (OspC) is quite variable. The ospC gene from B. burgdorferi isolate CA-11.2A, a clone in which ospC expression varies, was cloned and sequenced. The 5' flanking region of the gene contains at least 2 consensus promoter regions, as well as 2 large overlapping inverted repeats. Sequence comparison to other OspC proteins indicated that the CA-11.2A OspC is as closely related to OspC from 2 different genospecies of Lyme disease spirochaetes as it is to OspC from the prototype B. burgdorferi strain, B31. Comparisons of the OspC amino acid (aa) sequence with those in aa sequence databases revealed partial identity with the variable major proteins Vmp3 and Vmp24 of B. hermsii, a causative agent of tick-borne relapsing fever. An ospC probe hybridized to B. hermsii restriction fragments and linear plasmids that were also recognized by the vmp3 and vmp24 probes. OspC and these Vmp appear to be related, but their synthesis is regulated differently in the 2 species of spirochaetes. This represents a fascinating example of the evolution of the number, position, regulation and perhaps function of homologous genes in 2 related pathogens. These parameters may relate to characteristic properties of the pathogens and their separate tick vectors.
KW  - genes
KW  - Lyme disease
KW  - nucleotide sequences
KW  - promoters
KW  - proteins
KW  - Borrelia burgdorferi
KW  - Borrelia hermsii
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - DNA sequences
KW  - lyme borreliosis
KW  - OspC
KW  - promoter region
KW  - promoter sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Myocardial changes in acute Trypanosoma cruzi infection: ultrastructural evidence of immune damage and the role of microangiopathy.
AU  - Andrade, Z. A.
AU  - Andrade, S. G.
AU  - Correa, R.
AU  - Sadigursky, M.
AU  - Ferrans, V. J.
JO  - American Journal of Pathology
JF  - American Journal of Pathology
Y1  - 1994///
VL  - 144
IS  - 6
SP  - 1403
EP  - 1411
SN  - 0002-9440
AD  - Andrade, Z. A.: Pathology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 2N-240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009420.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Protozoology
N2  - Histological and ultrastructural studies of the hearts of dogs sacrificed 18 to 26 days after intraperitoneal inoculation with 4 × 105 blood forms of the 12 SF strain of Trypanosoma cruzi/kg of body weight disclosed myocarditis characterized by parasitic invasion of some myocytes, damage and necrosis of nonparasitized myocytes, and interstitial infiltration by mononuclear cells. Nonparasitized myocytes showed alterations ranging from mild oedema to severe myocytolysis. These changes often were accompanied by contacts of myocytes with lymphocytes (both granular and agranular) and macrophages. These contacts were characterized by focal loss of the myocyte basement membranes of the two cells. Contacts between lymphocytes and capillary endothelial cells were also frequent. Platelet aggregates and fibrin microthrombi were observed in some capillaries. The findings suggest that immune effector cells play a major role in the pathogenesis of the myocyte damage and the microangiopathy in acute Chagas' disease.
KW  - Chagas' disease
KW  - disease models
KW  - experimental infections
KW  - heart
KW  - histopathology
KW  - human diseases
KW  - immunopathology
KW  - parasites
KW  - pathology
KW  - ultrastructure
KW  - dogs
KW  - protozoa
KW  - Trypanosoma cruzi
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence, transcript characterization and polymorphisms of a Plasmodium falciparum gene belonging to the heat-shock protein (HSP) 90 family.
AU  - Su XinZhuan
AU  - Wellems, T. E.
JO  - Gene
JF  - Gene
Y1  - 1994///
VL  - 151
IS  - 1/2
SP  - 225
EP  - 230
SN  - 0378-1119
AD  - Su XinZhuan: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960802782.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0.  Subject Subsets: Protozoology
N2  - A gene (pfhsp86) encoding a member of the heat-shock protein 90 (HSP90) family was isolated from Plasmodium falciparum (Pf). The pfhsp86 coding region comprises 2 exons separated by an 0.8-kb intron with consensus splice junction sequences. The transcript itself is 3.4-kb long and includes a 0.65-kb 5′-untranslated region (UTR) and a 0.54-kb 3′-UTR. Upstream of the transcription start point (tsp) are putative promoter modules: an inverted CCAAT box, a G+C-rich sequence and several TATA sequences. Transcription is enhanced in erythrocyte-stage parasites cultivated at elevated temperatures (2- to 3-fold at 39°C and 3- to 4-fold at 41°C, relative to 37°C). The pfhsp86 gene maps within a chromosome 7 segment that is linked to chloroquine (Cq) response in a Pf cross. The parents of this cross (Dd2, HB3) differ in the first exon by 2 trinucleotide repeats, while more divergence is apparent between the introns. These trinucleotide repeat differences are linked to Cq response in the HB3 X Dd2 cross, but they did not predict Cq response in 9 Pf lines from different locations.
KW  - amino acid sequences
KW  - antimalarials
KW  - antiprotozoal agents
KW  - chloroquine
KW  - drug resistance
KW  - genes
KW  - heat shock proteins
KW  - human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs.
AU  - Shirai, M.
AU  - Pendleton, C. D.
AU  - Ahlers, J.
AU  - Takeshita, T.
AU  - Newman, M.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 152
IS  - 2
SP  - 549
EP  - 556
SN  - 0022-1767
AD  - Shirai, M.: (J.A. Berzofsky) National Cancer Institute, Building 10, Room 6B-12, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005474.  Publication Type: Journal Article.  Language: English. 
KW  - Cytotoxic T lymphocytes
KW  - human immunodeficiency viruses
KW  - Immune response
KW  - Immunology
KW  - Peptides
KW  - Vaccines
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - immunity reactions
KW  - immunological reactions
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 Nef activity in murine T cells: CD4 modulation and positive enhancement.
AU  - Rhee, S. S.
AU  - Marsh, J. W.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 152
IS  - 10
SP  - 5128
EP  - 5134
SN  - 0022-1767
AD  - Rhee, S. S.: (J.W. Marsh) Laboratory of Molecular Biology, National Institute of Mental Health, Building 36/Room 1B08, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942007098.  Publication Type: Journal Article.  Language: English. 
KW  - CD4 antigens
KW  - human immunodeficiency viruses
KW  - lymphocyte transformation
KW  - Nef protein
KW  - Pathogenesis
KW  - T lymphocytes
KW  - Mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - T cells
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.
AU  - Cheever, A. W.
AU  - Williams, M. E.
AU  - Wynn, T. A.
AU  - Finkelman, F. D.
AU  - Seder, R. A.
AU  - Cox, T. N.
AU  - Hieny, S.
AU  - Caspar, P.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 153
IS  - 2
SP  - 753
EP  - 759
SN  - 0022-1767
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002511.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 207137-56-2.  Subject Subsets: Tropical Diseases; Helminthology
N2  - Increasing evidence suggests that schistosome egg granulomas are primarily Th2 cellular reactions. Mice infected with Schistosoma mansoni were treated with a neutralizing mAb against IL-4 to evaluate the role of this cytokine in the generation of parasite egg-induced cell-mediated responses and hepatic pathology. Animals treated with anti-IL-4 before egg deposition showed decreased IL-4, IL-5, and IL-10 production in response to in vitro antigenic stimulations and decreased IL-5 and IL-13 mRNA levels in the liver. As observed previously, non-B, non-T cells were a major source of IL-4 in infected mice treated with control mAb, and the diminished IL-4 response in anti-IL-4-treated animals was shown to be caused at least in part by a reduction in the number of these cells, as well as by decreased secretion of IL-4 per cell. In contrast, production of the Th1 cytokines IL-2 and IFN-γ was elevated in anti-IL-4-treated infected mice in vitro, and the corresponding mRNAs in the liver were increased. Anti-IL-4 treatment did not consistently reduce the size of hepatic granulomas around S. mansoni eggs, but markedly inhibited granuloma formation in the lungs of the same animals after i.v. egg injection. Nevertheless, anti-IL-4 treated infected mice showed consistent and marked reductions in hepatic collagen deposition. These findings indicate that IL-4 plays a major role in the development of the Th2 response in S. mansoni-infected mice and contributes to the pathogenesis of hepatic fibrosis.
KW  - cytokines
KW  - experimental infections
KW  - fibrosis
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunopathology
KW  - interleukin 4
KW  - laboratory animals
KW  - parasites
KW  - schistosomiasis
KW  - T lymphocytes
KW  - treatment
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma mansoni
KW  - Schistosomatidae
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.
AU  - Sarin, A.
AU  - Clerici, M.
AU  - Blatt, S. P.
AU  - Hendrix, C. W.
AU  - Shearer,G. M.
AU  - Henkart, P. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 153
IS  - 2
SP  - 862
EP  - 872
SN  - 0022-1767
AD  - Sarin, A.: (P.A. Henkart) National Cancer Institute, Building 10, Room 4B-17, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942007109.  Publication Type: Journal Article.  Language: English. 
KW  - Apoptosis
KW  - HIV infections
KW  - Inhibition
KW  - Pathogenesis
KW  - Calpain
KW  - Cysteine protease inhibitors
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.
AU  - Oswald, I. P.
AU  - Caspar, P.
AU  - Jankovic, D.
AU  - Wynn, T. A.
AU  - Pearce, E. J.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 153
IS  - 4
SP  - 1707
EP  - 1713
SN  - 0022-1767
AD  - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
N1  - Accession Number: 19952003789.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2.  Subject Subsets: Tropical Diseases; Helminthology
N2  - In the mouse, infection with Schistosoma mansoni results in the selective induction of CD4+ T lymphocytes belonging to the Th2 subset. Schistosome ova are responsible for the development of Th2 responses seen in patently infected animals and the injection of eggs subcutaneously into the footpad leads to the development of elevated Th2 cytokine production by T cells in the draining popliteal lymph node. Using the egg infection model, the authors have shown that IL-12 suppressed schistosome egg-induced Th2 responses as evidenced by decreased IL-4, IL-5, and IL-10 secretion in vitro while increasing the production of the Th1 cytokine IFN-γ. Similar responses were obtained using either total lymph node cells or purified CD4+ T cells, indicating that IL-12 acts at the T cell level. When given as a single injection IL-12 was most effective at inhibiting Th2 responses when administered 2 days after egg inoculation, a time when T cells are still in a Th0 phase. The suppression of Th2 responses induced by IL-12 was blocked when the animals were simultaneously injected with neutralizing anti-IFN-γ mAb, either systemically or systemically plus locally. Anti-IFN-γ also inhibited the enhancement of IFN-γ responses induced by IL-12 but only if the mAb was administered systemically plus locally. NK cells are likely to be a major source of the immunoregulatory IFN-γ, because the effects of IL-12 on Th2 cytokine production were suppressed in mice treated with anti-asialo-GM1 Abs. Together these results suggest that IL-12 may have potential use in preventing or treating parasite-induced pathology resulting from Th2 cytokine production.
KW  - cytokines
KW  - disease models
KW  - experimental infections
KW  - helminths
KW  - immune response
KW  - immunotherapy
KW  - interferon
KW  - interleukin 10
KW  - interleukin 12
KW  - interleukin 4
KW  - interleukin 5
KW  - interleukins
KW  - ova
KW  - parasites
KW  - schistosomiasis
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii.
AU  - Gazzinelli, R. T.
AU  - Wysocka, M.
AU  - Hayashi, S.
AU  - Denkers, E. Y.
AU  - Hieny, S.
AU  - Caspar, P.
AU  - Trinchieri, G.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 153
IS  - 6
SP  - 2533
EP  - 2543
SN  - 0022-1767
AD  - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003846.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 9008-11-1.  Subject Subsets: Tropical Diseases; Protozoology
N2  - In vitro and in vivo studies were performed to assess the involvement of IL-12 in resistance to acute and chronic infection with an avirulent strain of Toxoplasma gondii. The authors' previous findings implicated macrophages as a major source of parasite-induced IL-12. This finding was confirmed by showing that peritoneal macrophages exposed to either live parasites or soluble tachyzoite Ags produce IL-12 protein. In mice, increased expression of IL-12 (p40) mRNA in both spleen and peritoneal cells was detected as early as 2 days postinfection. Treatment with neutralizing mAbs against IL-12 increased the susceptibility of C57BL/6, BALB/c, and severe combined immunodeficient (SCID) mice to acute infection, which resulted in 100% mortality within the first 15 days after parasite inoculation. In contrast, neutralization of endogenously produced IL-12 had no effect when given during chronic infection. In agreement with the survival data, treatment with anti-IL-12 resulted in decreased IFN-γ and enhanced Th2 (IL-4 and IL-10) cytokine synthesis by splenocytes when given during acute, but not chronic, toxoplasmosis. Sorting experiments on spleen cells from acutely infected mice indicated that both CD4+ lymphocytes and NK1.1+/CD3- cells contribute to the early IFN-γ response. In contrast, CD4+ cells were found to be the major source of the cytokine during chronic disease. Together, these results suggest that the stimulation of macrophage-derived IL-12 plays a major role in both the induction of resistance and Th1 cell subset selection in acute T. gondii infection, but may not be required to maintain established immunity.
KW  - acute course
KW  - cytokines
KW  - disease models
KW  - experimental infections
KW  - human diseases
KW  - immune response
KW  - infections
KW  - interferon
KW  - interleukin 12
KW  - interleukins
KW  - parasites
KW  - toxoplasmosis
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - severe course
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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ER  - 

TY  - JOUR
T1  - HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-α.
AU  - Maciejewski, J. P.
AU  - Weichold, F. F.
AU  - Young, N. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 153
IS  - 9
SP  - 4303
EP  - 4310
SN  - 0022-1767
AD  - Maciejewski, J. P.: Hematology Branch, National Heart, Lung and Blood Institute, Building 10, Room 7C112, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001625.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 308079-78-9. 
KW  - bone marrow
KW  - haematopoiesis
KW  - immunology
KW  - inhibition
KW  - pathogenesis
KW  - tumour necrosis factor
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood formation
KW  - cachectin
KW  - cachexin
KW  - haemopoiesis
KW  - hematopoiesis
KW  - human immunodeficiency virus type 1
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001625&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni.
AU  - Wynn, T. A.
AU  - Oswald, I. P.
AU  - Eltoum, I. A.
AU  - Caspar, P.
AU  - Lowenstein, C. J.
AU  - Lewis, F. A.
AU  - James, S. L.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1994///
VL  - 153
IS  - 11
SP  - 5200
EP  - 5209
SN  - 0022-1767
AD  - Wynn, T. A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003189.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 10102-43-9, 308079-78-9, 148157-34-0.  Subject Subsets: Tropical Diseases; Helminthology
N2  - C57BL/6 mice were vaccinated with irradiated cercariae of Schistosoma mansoni, and, at various times after challenge infection, total lung mRNA was isolated to assess the induction of several cytokines that previously had been shown in in vitro studies to be involved in the activation of macrophages and/or endothelial cells for nitric oxide (NO) production and killing of schistosomula. Vaccinated mice demonstrated a highly significant increase in IFN-γ mRNA upon subsequent infection when compared with infected nonvaccinated controls. A similar, although less dramatic, increase in 2 other macrophage-activating cytokines, TNF-α and IL-2, also was observed. In contrast, although the Th2 cytokines IL-4, IL-5, IL-10, and IL-13 were elevated in challenged vaccinated animals, only IL-10 and IL-13 showed increases that were significant with respect to the mRNA levels observed in challenged controls. Neutralization of IFN-γ reduced immunity in vaccinated animals and resulted in decreased IFN-γ, IL-2, IL-10, TNF-α, and IL-12 p40 but markedly increased IL-4, IL-5, and IL-13 mRNA expression and serum IgE levels. Pulmonary NO synthase expression was elevated in immunized mice at a time at which immune elimination of schistosomula is believed to occur. Moreover, suppression of NO synthase activity with the inhibitor aminoguanidine reduced immunity, as measured by a 32 to 33% increase in worm burden. Together, these data support previous in vitro studies that suggest a role for NO in schistosomulum killing. Furthermore, the observation that the down-regulatory cytokines IL-4, IL-10, and IL-13 are induced together with IFN-γ may provide an explanation for the failure of this vaccine to provide complete protection.
KW  - cytokines
KW  - disease models
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - interferon
KW  - interleukin 10
KW  - interleukin 13
KW  - interleukin 2
KW  - laboratory animals
KW  - nitric oxide
KW  - parasites
KW  - schistosomiasis
KW  - tumour necrosis factor
KW  - vaccines
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - cachectin
KW  - cachexin
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - tumor necrosis factor
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - A randomized pilot study of alternating or simultaneous zidovudine and didanosine therapy in patients with symptomatic human immunodeficiency virus infection.
AU  - Yarchoan, R.
AU  - Lietzau, J. A.
AU  - et al.
AU  - Nguyen, B. Y. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 169
IS  - 1
SP  - 9
EP  - 17
SN  - 0022-1899
AD  - Yarchoan, R.: Building 10, Room 12N226, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005523.  Publication Type: Journal Article.  Language: English.  Registry Number: 69655-05-6, 30516-87-1. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Combination therapy
KW  - Didanosine
KW  - HIV infections
KW  - Treatment
KW  - Zidovudine
KW  - AIDS
KW  - AZT
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - human immunodeficiency virus infections
KW  - multimodal treatment
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005523&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Persistence of type-specific human papillomavirus infection among cytologically normal women.
AU  - Hildesheim, A.
AU  - Schiffman, M. H.
AU  - et al.
AU  - Gravitt, P. E. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 169
IS  - 2
SP  - 235
EP  - 240
SN  - 0022-1899
AD  - Hildesheim, A.: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, 6130 Executive Blvd., EPN Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942028557.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Determinants of genital human papillomavirus (HPV) persistence in 393 women [in the USA] initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged ≥30 years had a higher percentage of persistence (65%) than those ≤24 years (32%, P = 0.02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = 0.11). These findings were independent of each other and of time between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection.AS
KW  - infections
KW  - persistence
KW  - women
KW  - North America
KW  - USA
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - Papillomaviridae
KW  - Human papillomavirus
KW  - Papovaviridae
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
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TY  - JOUR
T1  - Efficacy of unilamellar liposomal amphotericin B in treatment of pulmonary aspergillosis in persistently granulocytopenic rabbits: the potential role of bronchoalveolar D-mannitol and serum galactomannan as markers of infection.
AU  - Francis, P.
AU  - Lee, J. W.
AU  - Hoffman, A.
AU  - Peter, J.
AU  - Francesconi, A.
AU  - Bacher, J.
AU  - Shelhamer, J.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 169
IS  - 2
SP  - 356
EP  - 368
SN  - 0022-1899
AD  - Francis, P.: T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941201663.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 1397-89-3, 69-65-8.  Subject Subsets: Medical & Veterinary Mycology
N2  - A model of primary pulmonary Aspergillus fumigatus infection in rabbits was developed to reproduce the persistent levels of profound granulocytopenia and the histopathological features of bronchopneumonia, vascular invasion and haemorrhagic infarction encountered in humans. D-Mannitol was detectable in bronchoalveolar lavage fluid by GLC/MS and galactomannan was measurable in serum by latex agglutination immunoassay. A pharmacokinetically distinctive unilamellar vesicle formulation of intravenous liposomal amphotericin B (5 mg/kg daily) compared with intravenous high-dose conventional desoxycholate amphotericin B (1 mg/kg daily) was more effective in preventing nephrotoxicity, increasing survival, reducing the number of viable organisms and in decreasing tissue injury by Aspergillus. It is suggested that D-mannitol in lavage fluid and galactomannan in serum may be useful markers of pulmonary aspergillosis. It is concluded that liposomal amphotericin B is more effective and safer than desoxycholate amphotericin B in the treatment of pulmonary aspergillosis in profoundly granulocytopenic rabbits.
KW  - administration
KW  - amphotericin B
KW  - antifungal agents
KW  - aspergillosis
KW  - diagnosis
KW  - disease models
KW  - drug therapy
KW  - experimental infections
KW  - galactomannans
KW  - infections
KW  - liposomes
KW  - lungs
KW  - mannitol
KW  - predisposition
KW  - serology
KW  - techniques
KW  - therapy
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - bronchoalveolar lavage fluid
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Immunity to onchocerciasis: identification of a putatively immune population in a hyperendemic area of Ecuador.
AU  - Elson, L. H.
AU  - Guderian, R. H.
AU  - Araujo, E.
AU  - Bradley, J. E.
AU  - Days, A.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 169
IS  - 3
SP  - 588
EP  - 594
SN  - 0022-1899
AD  - Elson, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950800174.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 308067-58-5, 308067-57-4.  Subject Subsets: Helminthology; Tropical Diseases
N2  - The existence of immunity to Onchocerca volvulus (Ov) infection is suggested by the presence of uninfected persons in hyperendemic areas. A major barrier to the study of immunity has been the correct identification of putatively immune (PI) subjects. To identify a PI group in a hyperendemic area of Esmeraldas Province in Ecuador, clinical and epidemiological information was combined with a polymerase chain reaction (PCR)-based assay identifying Ov DNA in skin snips and a recombinant antigen-based ELISA. Comparison of immune responses revealed that PI subjects (n=42) had significantly lower levels of Ov-specific IgG, IgG subclasses, and IgE than infected (INF) subjects (n=45). Female subjects were significantly more likely to be PI than male subjects, and INF female subjects had significantly lower levels of Ov-specific IgG, IgG1 and IgG3 than INF male subjects.
KW  - helminths
KW  - human diseases
KW  - IgG
KW  - immune response
KW  - immunity
KW  - immunoglobulins
KW  - onchocerciasis
KW  - parasites
KW  - polymerase chain reaction
KW  - Ecuador
KW  - South America
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - PCR
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Polymerase chain reaction-based diagnosis of Onchocerca volvulus infection: improved detection of patients with onchocerciasis.
AU  - Zimmerman, P. A.
AU  - Guderian, R. H.
AU  - Aruajo, E.
AU  - Elson, L.
AU  - Phadke, P.
AU  - Kubofcik, J.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 169
IS  - 3
SP  - 686
EP  - 689
SN  - 0022-1899
AD  - Zimmerman, P. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950800177.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - To assess the efficacy and utility of a polymerase chain reaction (PCR)-based diagnosis for Onchocerca volvulus (Ov) infection, skin snips were examined from 94 persons in an Ov-endemic region of Ecuador (Esmeraldas), and results were compared in a blinded fashion with those of a PCR assay based on the Onchocerca-specific repetitive DNA sequence, O-150. All 60 patients microfilaria-positive on skin snip examination were positive in the PCR-based assay. In addition, 13 of 34 who were microfilaria-negative by skin snips were positive in the PCR assay. This suggests that the PCR-based assay is significantly more sensitive than current methods.
KW  - diagnosis
KW  - helminths
KW  - human diseases
KW  - molecular genetics
KW  - onchocerciasis
KW  - parasites
KW  - polymerase chain reaction
KW  - Ecuador
KW  - South America
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - biochemical genetics
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - PCR
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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TY  - JOUR
T1  - Elevated levels of tumor necrosis factor-α in Zaïrian neonate plasmas: implications for perinatal infection with the human immunodeficiency virus.
AU  - Brown, C. C.
AU  - Poli, G.
AU  - et al.
AU  - Lubaki, N. (
AU  - Fauci, A. S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 169
IS  - 5
SP  - 975
EP  - 980
SN  - 0022-1899
AD  - Brown, C. C.: (A.S. Fauci) National Institutes of Health, Building 31, Room 7A03, Bethesda, MD 29892, USA.
N1  - Accession Number: 19942006397.  Publication Type: Journal Article.  Language: English.  Registry Number: 308079-78-9. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Cytokines
KW  - disease course
KW  - HIV infections
KW  - Immunology
KW  - Pathogenesis
KW  - Tumour necrosis factor
KW  - AIDS
KW  - cachectin
KW  - cachexin
KW  - disease progression
KW  - human immunodeficiency virus infections
KW  - Paediatric infections
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006397&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dynamics of emergence.
AU  - Krause, R. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 2
SP  - 265
EP  - 271
SN  - 0022-1899
AD  - Krause, R. M.: Fogarty International Center, National Institutes of Health, 9000 Rockville Pike, Building 31, Room B2C02, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942050998.  Publication Type: Journal Article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - Infectious diseases
KW  - Mathematical models
KW  - Microbiology
KW  - AIDS
KW  - communicable diseases
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050998&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quantitative analysis of viral burden in tissues from adults and children with symptomatic human immunodeficiency virus type 1 infection assessed by polymerase chain reaction.
AU  - Sei, S.
AU  - Kleiner, D. E.
AU  - et al.
AU  - Kopp, J. B. (
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 2
SP  - 325
EP  - 333
SN  - 0022-1899
AD  - Sei, S.: Pediatric Branch, National Cancer Institute, NIH Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942051005.  Publication Type: Journal Article.  Language: English. 
KW  - Colon
KW  - HIV infections
KW  - lungs
KW  - Lymph nodes
KW  - Pathology
KW  - Polymerase chain reaction
KW  - Tissues
KW  - human immunodeficiency virus infections
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular characterization of Hawaii virus and other Norwalk-like viruses: Evidence for genetic polymorphism among human caliciviruses.
AU  - Lew, J. F.
AU  - Kapikian, A. Z.
AU  - Valdesuso, J.
AU  - Green, K. Y.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 3
SP  - 535
EP  - 542
SN  - 0022-1899
AD  - Lew, J. F.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006028.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Public Health
N2  - Hawaii virus (HV), from a 1971 family outbreak of gastroenteritis, is serotypically distinct from Norwalk virus (NV), recently identified as a human calicivirus by molecular analysis. About 2600 consecutive nucleotides of the HV genome (including those encoding the viral capsid protein) and part of the polymerase region of three other viruses (MDV1, MDV6, and SV7) were sequenced. Comparison of the amino acid sequence of the capsid protein of HV with NV and other human caliciviruses (Toronto virus [TV24], Desert Shield virus [DSV395], and Southampton virus [SHV]) demonstrated the existence of two major genetic groups (genogroups) typified by HV and NV. HV had 76% identity with TV24 and 48% identity with NV, DSV395, or SHV. In addition, comparison of part of the polymerase protein of HV with other human caliciviruses also showed that there were these two genogroups. The large genetic diversity between the capsid sequence of HV and NV is consistent with their serotypic distinctiveness.
KW  - genetic polymorphism
KW  - molecular genetics
KW  - Caliciviridae
KW  - Norwalk virus
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Norovirus
KW  - Caliciviridae
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006028&site=ehost-live&scope=site
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TY  - JOUR
T1  - Induction of hepatic pathology in SCID-Hu mice engrafted with peripheral blood lymphocytes of patients with schistosomiasis japonica.
AU  - Kresina, T. F.
AU  - Wisnewski, A.
AU  - Love-Homan, L.
AU  - Ramirez, B.
AU  - Neil, G. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 3
SP  - 733
EP  - 736
SN  - 0022-1899
AD  - Kresina, T. F.: National Institute of Digestive Diseases and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006041.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 9008-11-1, 207137-56-2.  Subject Subsets: Tropical Diseases; Helminthology
N2  - SCID mice were engrafted with peripheral blood lymphocytes (PBL) derived from persons (from the Philippines) currently or previously infected with Schistosoma japonicum. After immunization with soluble worm antigenic preparation, the SCID-Hu mice were analysed for a human immune response. ELISA revealed a low titre of human antibody recognizing soluble egg antigens in 2 of 10 mice. One mouse had detectable levels of interleukin (IL)-2 and γ-interferon, TH1 phenotype cytokines. All mice had elevated levels of IL-4, a TH2 phenotype cytokine. The human cytokine profile of the mice paralleled the patients' serum profile at clinical examination. In addition, all mice had substantial hepatic pathology, including inflammatory cell infiltrates and macrovesicular fat deposition. The data indicate that activation of PBL from patients with a history of schistosomiasis japonica infection can result in focal hepatic pathology, which may be driven by specific cytokines.
KW  - disease models
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - immunopathology
KW  - interferon
KW  - interleukin 12
KW  - interleukin 4
KW  - laboratory animals
KW  - liver
KW  - lymphocytes
KW  - parasites
KW  - pathology
KW  - schistosomiasis
KW  - scid mice
KW  - Asia
KW  - Philippines
KW  - man
KW  - mice
KW  - Schistosoma japonicum
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - bilharzia
KW  - bilharziasis
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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TY  - JOUR
T1  - Onchocerciasis in endemic and nonendemic populations: differences in clinical presentation and immunologic findings.
AU  - McCarthy, J. S.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 3
SP  - 733
EP  - 736
SN  - 0022-1899
AD  - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006168.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 37341-29-0.  Subject Subsets: Tropical Diseases; Helminthology
N2  - To characterize the clinical and laboratory features of onchocerciasis in visitors from the USA to endemic areas and to compare them with those seen in endemic subjects, 20 visitors (who had returned from Central or West Africa) and 21 endemic subjects (19 from Guatemala, and one each from Cameroon and Sierra Leone) with onchocerciasis were evaluated. Dermatitis was the most frequent clinical finding among the returned visitors. None had nodules or eye disease and, in contrast to the endemic subjects, microfiladermia was often absent or of low density. All persons studied had antibody responses measurable by ELISA to both soluble Onchocerca volvulus antigen and a panel of diagnostic recombinant antigens. Eosinophil and IgE levels were significantly higher in the endemic group, as was the capacity of peripheral blood mononuclear cells from this group to produce the T helper cell-like cytokines interleukin-4 and -5. It is likely that the chronicity and intensity of infection in endemic subjects account for the clinical and immunological differences observed between the 2 groups.
KW  - antigens
KW  - clinical aspects
KW  - dermatitis
KW  - eosinophils
KW  - helminths
KW  - IgE
KW  - immunology
KW  - imported infections
KW  - onchocerciasis
KW  - parasites
KW  - T lymphocytes
KW  - travellers
KW  - Africa
KW  - Cameroon
KW  - Central America
KW  - Guatemala
KW  - North America
KW  - Sierra Leone
KW  - USA
KW  - man
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - America
KW  - CACM
KW  - Central America
KW  - Latin America
KW  - Anglophone Africa
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - West Africa
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - antigenicity
KW  - clinical picture
KW  - eosinophil leukocytes
KW  - immunogens
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Antifungal activity of elutriated human monocytes against Aspergillus fumigatus hyphae: enhancement by granulocyte-macrophage colony-stimulating factor and interferon-γ.
AU  - Roilides, E.
AU  - Holmes, A.
AU  - Blake, C.
AU  - Venzon, D.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 4
SP  - 894
EP  - 899
SN  - 0022-1899
AD  - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200819.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The antifungal activity of elutriated monocytes (EHM) against Aspergillus hyphae was compared with that of polymorphonuclear leukocytes (PMNL). The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-γ (IFN-γ) on superoxide anion (O2-) release and on hyphal damage caused by EHM against unopsonized A. fumigatus hyphae was investigated. EHM had anti-hyphal activity comparable with that of PMNL. GM-CSF significantly augmented O2- release by EHM in response to PMA. Also, both GM-CSF and IFN-γ significantly enhanced the antifungal activity of EHM compared with untreated controls. It is concluded that EHM have demonstrable antifungal activity against Aspergillus hyphae that may be increased by GM-CSF and IFN-γ, suggesting their potential therapeutic role in immune reconstitution of effector cells.
KW  - cytokines
KW  - immunology
KW  - monocytes
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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ER  - 

TY  - JOUR
T1  - Transient changes in cytokine profiles following ivermectin treatment of onchocerciasis.
AU  - Steel, C.
AU  - Lujan-Trangay, A.
AU  - Gonzalez-Peralta, C.
AU  - Zea-Flores, G.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 4
SP  - 962
EP  - 970
SN  - 0022-1899
AD  - Steel, C.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950802278.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 85898-30-2, 207137-56-2, 70288-86-7, 308079-78-9, 9008-11-1, 130068-27-8, 102524-44-7.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Cytokine production by peripheral blood mononuclear cells after antigen or mitogen stimulation was assessed before and after semiannual ivermectin treatment (with 150 µg/kg) of 27 male patients with onchocerciasis in Guatemala. Before treatment, Onchocerca volvulus antigen (OvA) elicited interleukin (IL)-5 production but inhibited production of IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), and tumour necrosis factor-α. 6 months after the first dose of ivermectin, there were increases in IL-2, IL-4, IL-5 and interferon-γ responses to mitogen and in the GM-CSF and IL-10 responses to OvA. By 24 months (after 4 ivermectin doses), OvA-induced GM-CSF production and mitogen-induced IL-2 and IL-10 production remained elevated above pre-treatment levels, whereas that of other cytokines returned to or below pretreatment levels.
KW  - anthelmintics
KW  - colony stimulating factor
KW  - cytokines
KW  - drug therapy
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - interleukin 10
KW  - interleukin 2
KW  - interleukin 4
KW  - interleukin 5
KW  - ivermectin
KW  - onchocerciasis
KW  - parasites
KW  - tumour necrosis factor
KW  - Central America
KW  - Guatemala
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - America
KW  - CACM
KW  - Central America
KW  - Developing Countries
KW  - Latin America
KW  - cachectin
KW  - cachexin
KW  - chemotherapy
KW  - granulocyte macrophage colony stimulating factor
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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TY  - JOUR
T1  - Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus.
AU  - Davey, R. T., Jr.
AU  - Boenning, C. M.
AU  - Herpin, B. R.
AU  - Batts, D. H.
AU  - Metcalf, J. A.
AU  - Wathen, L.
AU  - Cox, S. R.
AU  - Polis, M. A.
AU  - Kovacs, J. A.
AU  - Falloon, J.
AU  - Walker, R. E.
AU  - Salzman, N.
AU  - Masur, H.
AU  - Lane, H. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 5
SP  - 1180
EP  - 1188
SN  - 0022-1899
AD  - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases and Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland USA.
N1  - Accession Number: 19952001131.  Publication Type: Journal Article.  Language: English. 
KW  - exotoxins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - soluble cd4 antigens
KW  - toxicity
KW  - treatment
KW  - Pseudomonas aeruginosa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Pseudomonas
KW  - Pseudomonadaceae
KW  - Pseudomonadales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - fusion toxin
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - soluble CD4
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Antifilarial IgG4 antibodies in children from filaria-endemic areas correlate with duration of infection and are dissociated from antifilarial IgE antibodies.
AU  - Mahanty, S.
AU  - Day, K. P.
AU  - Alpers, M. P.
AU  - Kazura, J. W.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 5
SP  - 1339
EP  - 1343
SN  - 0022-1899
AD  - Mahanty, S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803051.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4.  Subject Subsets: Helminthology; Tropical Diseases
N2  - This study investigated the influence that intensity and duration of transmission have on host IgG4 and IgE antibody responses to infection with Wuchereria bancrofti. The serum samples were obtained from children of villages in Papua New Guinea. One of these villages, Bonahoi, was subject to an insecticide spraying programme for a 20-year period, which ended 3 years prior to collection of serum samples in 1984. It thus provides a source of samples obtained from individuals subjected to potential exposure to infection of a short-term nature, and these are compared with samples from 3 nearby (~50 km) untreated villages. Although the group of subjects from the sprayed village was rather small (n = 9; n = 33 for non-sprayed), it was possible to demonstrate significantly lower (P &lt;0.01) IgG4 levels in children from the sprayed village. In contrast, antifilarial IgE was elevated to similar levels in children from both types of village. These findings can be interpreted as indicating that the IgG4, but not the IgE, response to W. bancrofti in this area of transmission may reflect the duration of infection or cumulative exposure to infective larvae. This interpretation is supported by increasing levels of anti-parasite IgG4 up until 16 years of age in children from unsprayed villages. Conversely, IgE levels in the same villages have plateaued many years before this. However, the presence of significant IgE responses in children from sprayed villages may illustrate the potential of this isotype as an early marker of infection. W. Harnett&lt;new para&gt;ADDITIONAL ABSTRACT:&lt;new para&gt;Antifilarial antibody levels in 9 children residing in a village (Bonahoi) in East Sepik Province, Papua New Guinea, where transmission of Wuchereria bancrofti had been reduced (microfilaria carrier rate 6.6%) by repeated insecticide spraying (from 1961 to 1981) were compared (in 1984) with levels in residents (33 children, 17 adults) of 3 nearby villages where no control measures had been used (microfilaria carrier rates 60 to 80%). Antifilarial IgG4 levels were significantly lower in children from the sprayed village than in children or adults in non-sprayed villages, and correlated with age and intensity of microfilaraemia. In contrast, antifilarial IgE was elevated to similar levels in children and adults from both the sprayed village and the unsprayed villages. It is concluded that antifilarial IgG4 (and not IgE) levels in endemic populations appear to be directly related to the duration of infection or to the cumulative exposure to infective vectors.
KW  - antibodies
KW  - children
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - IgG
KW  - immune response
KW  - immunoglobulins
KW  - infections
KW  - parasites
KW  - Oceania
KW  - Papua New Guinea
KW  - man
KW  - nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Wuchereria
KW  - Onchocercidae
KW  - ACP Countries
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - New Guinea
KW  - Melanesia
KW  - Australasia
KW  - Oceania
KW  - Pacific Islands
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Genotyping of human T cell lymphotropic virus type I using Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: insights into viral evolution and dissemination.
AU  - Nerurkar, V. R.
AU  - Song, K. J.
AU  - Bastian, I. B.
AU  - Garin, B.
AU  - Franchini, G.
AU  - Yanagihara, R.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 6
SP  - 1353
EP  - 1360
SN  - 0022-1899
AD  - Nerurkar, V. R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952001724.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
KW  - DNA sequencing
KW  - evolution
KW  - genetic variation
KW  - human diseases
KW  - origin
KW  - phylogeny
KW  - polymerase chain reaction
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - HTLV-BLV group
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001724&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Response of human polymorphonuclear leukocytes and monocytes to Trichosporon beigelii: host defense against an emerging opportunistic pathogen.
AU  - Lyman, C. A.
AU  - Garrett, K. F.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1994///
VL  - 170
IS  - 6
SP  - 1557
EP  - 1565
SN  - 0022-1899
AD  - Lyman, C. A.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951200708.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Functional responses of polymorphonuclear leukocytes (PMNL) and elutriated human monocytes (EHM) to T. beigelii were investigated. There was significantly less PMNL phagocytosis (P&lt;0.001) and killing (P&lt;0.001) of T. beigelii isolates than of Candida albicans. However, levels of superoxide anions generated by PMNL in response to T. beigelii and C. albicans were comparable. Pretreatment of PMNL with granulocyte colony-stimulating factor or interferon-γ (IFN-γ) did not significantly enhance fungicidal activity. Killing of T. beigelii by EHM was also significantly impaired compared with killing of C. albicans (P&lt;0.001). However, pretreatment of EHM with macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor or IFN-γ all resulted in enhanced fungicidal activity. It is concluded that phagocytosis and killing of T. beigelii by PMNL and EHM are significantly less efficient than that of C. albicans. However, it is suggested that monocytes may be more important in the control of Trichosporon than previously shown.
KW  - cytokines
KW  - immunology
KW  - leukocytes
KW  - monocytes
KW  - phagocytosis
KW  - Candida albicans
KW  - Trichosporon beigelii
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungus
KW  - Hyphomycetes
KW  - killing
KW  - leucocytes
KW  - white blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200708&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase.
AU  - Williamson, P. R.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1994///
VL  - 176
IS  - 3
SP  - 656
EP  - 664
SN  - 0021-9193
AD  - Williamson, P. R.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941200875.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 80498-15-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - To characterize the events involved in melanin synthesis in C. neoformans, an enzyme with diphenol oxidase activity was purified and its gene was cloned. The enzyme was purified as a glycosylated 75-kDa protein which migrated at 66 kDa on SDS-PAGE after deglycosylation by endoglycosidase F. Substrate specificity resembled that of a laccase in that it oxidized multiple diphenolic and diamino compounds. Dopamine was shown by mass spectroscopy to be oxidized to decarboxy dopachrome, an intermediate of melanin synthesis. The enzyme contained 4.1±0.1 mol of copper/mol and resembled a laccase in its absorbance spectrum, with a peak at 610 nm and the shoulder at 320 nm, corresponding to the absorbance of a type I and type III copper, respectively. The cloned gene of C. neoformans laccase (CNLAC1) contained a single open reading frame encoding a polypeptide of 624 amino acids. The encoded polypeptide contained a presumptive leader sequence, on the basis of its relative hydrophobicity and by comparison of the sequence to that of the N-terminal sequence of the purified enzyme. CNLAC1 also contained 14 introns ranging from 52 to 340 bases long. Transcriptional activity of CNLAC1 was derepressed in the absence of glucose and corresponded to an increase in enzymatic activity.
KW  - biochemistry
KW  - genetics
KW  - laccase
KW  - nucleotide sequences
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - DNA sequences
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200875&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi.
AU  - Samuels, D. S.
AU  - Marconi, R. T.
AU  - Huang WaiMun
AU  - Garon, C. F.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1994///
VL  - 176
IS  - 10
SP  - 3072
EP  - 3075
SN  - 0021-9193
AD  - Samuels, D. S.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950502860.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 4434-05-3.  Subject Subsets: Medical & Veterinary Entomology
N2  - Mutants of B. burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase [DNA topoisomerase (ATP-hydrolysing)], were isolated and characterized. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents.
KW  - antibiotics
KW  - coumamycin
KW  - drug resistance
KW  - genes
KW  - molecular genetics
KW  - mutants
KW  - nucleotide sequences
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - coumermycin
KW  - DNA sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502860&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange.
AU  - Marconi, R. T.
AU  - Samuels, D. S.
AU  - Landry, R. K.
AU  - Garon, C. F.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1994///
VL  - 176
IS  - 15
SP  - 4572
EP  - 4582
SN  - 0021-9193
AD  - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19950502857.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Analysis of the ospD gene has revealed that this gene is not universal among Lyme disease spirochaete isolates. The gene was found to be carried by 90, 50 and 24% of the Borrelia garinii, B. afzelii and B. burgdorferi isolates tested. Size variability in the ospD-encoding plasmid was also observed. Sequence analysis has demonstrated the presence of various numbers of a 17-bp repeated sequence in the upstream control (promoter) region of the gene. In addition, a region within the coding sequence where various insertions, deletions and direct repeats occur was identified. ospD gene sequences from 31 different isolates were determined and utilized in pairwise sequence comparisons and construction of a gene tree. The analyses suggest that the ospD gene was the target of several recombinational events and that the gene was recently acquired by Lyme disease spirochaetes and laterally transferred between species.
KW  - DNA
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - plasmids
KW  - Borrelia afzelii
KW  - Borrelia burgdorferi
KW  - Borrelia garinii
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502857&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.
AU  - Wynn, T. A.
AU  - Eltoum, I.
AU  - Oswald, I. P.
AU  - Cheever, A. W.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1994///
VL  - 179
IS  - 5
SP  - 1551
EP  - 1561
SN  - 0022-1007
AD  - Wynn, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952006080.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Registry Number: 9008-11-1.  Subject Subsets: Tropical Diseases; Helminthology
N2  - Morbidity in human schistosomiasis due to Schistosoma mansoni results primarily from the deposition of parasite eggs in portal areas where they induce a granulomatous response. In mice infected with this helminth granuloma formation is a CD4+ T helper (Th) cell-dependent process that is associated with a strong Th2 cytokine response which appears to evolve through a Th0 phase. In this report, the authors asked whether endogenously synthesized or exogenously induced interferon (IFN)γ through its suppression of Th2 cell expansion exerts a regulatory role on egg pathology. Depletion of IFN-γ or natural killer cells resulted in a marked enhancement of granuloma formation around intravenously injected eggs and was associated with increased Th2 and decreased Th1 and interleukin (IL)12 mRNA expression. Similar changes occurred when egg-injected mice were treated with neutralizing monoclonal antibodies specific for IL-12 indicating a role for this cytokine in the regulation of the granulomatous response. In contrast, treatment with exogenous rIL-12 profoundly inhibited primary granuloma formation while increasing IFN-γ, IL-2, IL-10, and IL-12 pulmonary mRNA levels and suppressing IL-4, IL-5, IL-6 and IL-13 mRNA expression. Cytokine depletion studies indicated that the effects of IL-12 could be attributed primarily to increased IFN-γ. Importantly, IL-12 also inhibited secondary granuloma formation in mice pre-sensitized with eggs demonstrating a role for the cytokine in reversing established Th2-type responses. Moreover, mice sensitized with eggs in combination with IL-12 to precommit them toward a Th1 response developed only minimal granulomas upon subsequent egg challenge. The latter findings suggest that simultaneous vaccination with antigen plus IL-12 may provide a strategy for the prevention of schistosome egg pathology as well as other diseases stemming from Th2 cytokine production.
KW  - animal models
KW  - cytokines
KW  - granuloma
KW  - helminths
KW  - human diseases
KW  - immunopathology
KW  - interferon
KW  - interleukin 12
KW  - interleukins
KW  - parasites
KW  - schistosomiasis
KW  - T lymphocytes
KW  - man
KW  - mice
KW  - Schistosoma mansoni
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006080&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion.
AU  - Chitnis, C. E.
AU  - Miller, L. H.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1994///
VL  - 180
IS  - 2
SP  - 497
EP  - 506
SN  - 0022-1007
AD  - Chitnis, C. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952001654.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Tropical Diseases; Protozoology
N2  - Plasmodium vivax and the related monkey malaria parasite, P. knowlesi, require interaction with the Duffy blood group antigen, a receptor for a family of chemokines that includes interleukin 8, to invade human erythrocytes. One P. vivax and 3 P. knowlesi proteins that serve as erythrocyte binding ligands in such interactions share sequence homology. Expression of different regions of the P. vivax protein in COS7 cells identified a cysteine-rich domain that bound Duffy blood group-positive but not Duffy blood group-negative human erythrocytes. The homologous domain of the P. knowlesi proteins also bound erythrocytes, but had different specificities. The P. vivax and P. knowlesi binding domains lie in 1 of 2 regions of homology with the P. falciparum sialic acid binding protein, another erythrocyte binding ligand, indicating conservation of the domain for erythrocyte binding in evolutionarily distant malaria species. The binding domains of these malaria ligands represent potential vaccine candidates and targets for receptor-blockade therapy.
KW  - blood group antigens
KW  - cell invasion
KW  - erythrocyte invasion
KW  - erythrocytes
KW  - human diseases
KW  - ligands
KW  - parasites
KW  - vaccines
KW  - man
KW  - Plasmodium
KW  - Plasmodium knowlesi
KW  - Plasmodium vivax
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Plasmodium
KW  - blood red cells
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001654&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor Vβ5-bearing CD8+ lymphocytes.
AU  - Denkers, E. Y.
AU  - Caspar, P.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1994///
VL  - 180
IS  - 3
SP  - 985
EP  - 994
SN  - 0022-1007
AD  - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950808939.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - In order to investigate early immune responses to Toxoplasma gondii, the capacity of nonimmune splenocytes to respond in vitro to intact tachyzoites and soluble tachyzoite antigen (Ag) was examined. Both types of stimuli induced high levels of proliferation as well as interferon-γ (IFN-γ) secretion. Based on several key criteria, the response appeared to be driven by a superantigen present in the parasite. Thus, stimulation of C57BL/6 spleen cells with T.gondii resulted in a preferential three-fold expansion of a T lymphocyte population expressing the Vβ5 chain of the T cell receptor. Proliferation was induced using irradiated Ag-pulsed and infected splenic adherent cells, and was blocked by a major histocompatibility complex class II-specific monoclonal antibody. It was demonstrated that the response could be mediated by allogeneic class II molecules, and that it does not require cellular Ag processing. These results provide the first description of a superantigen activity in a protozoan pathogen. Superantigen-driven expansion of IFN-γ-secreting CD8+ lymphocytes may play a role in the development of the dominant IFN-γ-dependent, cell-mediated immunity characteristic of infection with this parasite.
KW  - cell mediated immunity
KW  - human diseases
KW  - in vitro
KW  - interferon
KW  - lymphocyte transformation
KW  - parasites
KW  - T lymphocytes
KW  - toxoplasmosis
KW  - protozoa
KW  - Toxoplasma gondii
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cellular immunity
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa.
AU  - Song, K. J.
AU  - Nerurkar, V. R.
AU  - Saitou, N.
AU  - Lazo, A.
AU  - Blakeslee, J. R.
AU  - Miyoshi, I.
AU  - Yanagihara, R.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1994///
VL  - 199
IS  - 1
SP  - 56
EP  - 66
SN  - 0042-6822
AD  - Song, K. J.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001613.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
KW  - evolution
KW  - natural history
KW  - nucleotide sequences
KW  - phylogeny
KW  - man
KW  - retroviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA sequences
KW  - simian T-cell lymphotropic virus type I
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001613&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An increase in p50/p65 NF-kB binding to the HIV-1 LTR is not sufficient to increase viral expression in the primary human astrocyte.
AU  - Conant, K.
AU  - Atwood, W. J.
AU  - Traub, R.
AU  - Tornatore, C.
AU  - Major, E. O.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1994///
VL  - 205
IS  - 2
SP  - 586
EP  - 590
SN  - 0042-6822
AD  - Conant, K.: Laboratory of Molecular Medicine and Neuroscience, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005783.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 308079-78-9. 
KW  - cellular biology
KW  - gene expression
KW  - growth factors
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - regulation
KW  - tumour necrosis factor
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - astrocytes
KW  - cachectin
KW  - cachexin
KW  - cell biology
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - phorbol myristate acetate
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005783&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 modulates the expression of gelatinase A and B in monocytic cells.
AU  - Kalebic, T.
AU  - Masiero, L.
AU  - Onisto, M.
AU  - Garbisa, S.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1994///
VL  - 205
IS  - 2
SP  - 1243
EP  - 1249
SN  - 0006-291X
AD  - Kalebic, T.: Molecular Oncology Secion, Pediatric Branch, National Cancer Institute, NIH Building 10/13N240, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19962002131.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 63231-63-0, 308079-78-9. 
KW  - HIV infections
KW  - human diseases
KW  - modulation
KW  - molecular biology
KW  - RNA
KW  - tumour necrosis factor
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - gelatinases
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - proteolytic enzymes
KW  - ribonucleic acid
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002131&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Malaria pathogenesis.
AU  - Miller, L. H.
AU  - Good, M. F.
AU  - Milon, G.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1994///
VL  - 264
IS  - 5167
SP  - 1878
EP  - 1883
SN  - 0036-8075
AD  - Miller, L. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950800758.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - This article provides an overview of malaria pathogenesis under the headings: the immune system (parasite survival strategy and disease); invasion of erythrocytes; persistent infections and reinfections; severe disease; cerebral malaria; severe anaemia; pregnancy, the fetus and the newborn.
KW  - human diseases
KW  - malaria
KW  - parasites
KW  - pathogenesis
KW  - reviews
KW  - Apicomplexa
KW  - man
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800758&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum.
AU  - Sim, B. K. L.
AU  - Chitnis, C. E.
AU  - Wasniowska, K.
AU  - Hadley, T. J.
AU  - Miller, L. H.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1994///
VL  - 264
IS  - 5167
SP  - 1941
EP  - 1944
SN  - 0036-8075
AD  - Sim, B. K. L.: Laboratory of Malaria Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950800760.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A 175 000 MW erythrocyte binding protein, EBA-175, of Plasmodium falciparum mediates the invasion of erythrocytes. The erythrocyte receptor for EBA-175 is dependent on sialic acid. The domain of EBA-175 that binds erythrocytes was identified as region II with the use of truncated portions of EBA-175 expressed on COS cells. Region II, which contains a cysteine-rich motif, and native EBA-175 bind specifically to glycophorin A, but not to glycophorin B, on the erythrocyte membrane. Erythrocyte recognition of EBA-175 requires both sialic acid and the peptide backbone of glycophorin A. The identification of both the receptor and ligand domains may suggest rational designs for receptor blockade and vaccines.
KW  - biochemistry
KW  - cell invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - human diseases
KW  - ligands
KW  - malaria
KW  - parasites
KW  - receptors
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - blood red cells
KW  - erythrocyte binding protein
KW  - glycophorins
KW  - parasite host relationships
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800760&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - CD26 antigen and HIV fusion?
AU  - Broder, C. C.
AU  - Nussbaum, O.
AU  - Gutheil, W. G.
AU  - Bachovchin, W. W.
AU  - Berger, E. A.
AU  - Patience, C.\McKnight, A.\Clapham, P. R.\Boyd, M. T.\Weiss, R. A.\Schulz, T. F.\Camerini, D.\Planelles, V.\Chen, I. S. Y.\Alizon, M.\Dragic, T.\Callebaut, C.\Jacotot, E.\Krust, B.\Hovanessian, A. G.
T2  - Science, USA
JO  - Science, USA
JF  - Science, USA
Y1  - 1994///
VL  - 264
IS  - May 20
SP  - 1156
EP  - 1159
AD  - Broder, C. C.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006776.  Publication Type: Correspondence.  Language: English. 
KW  - Cell fusion
KW  - cellular biology
KW  - HIV infections
KW  - Molecular biology
KW  - Pathogenesis
KW  - Receptors
KW  - CD26
KW  - cell biology
KW  - human immunodeficiency virus infections
KW  - Viral entry
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006776&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Potential role of human cytomegalovirus and p53 interaction in coronary restenosis.
AU  - Speir, E.
AU  - Modali, R.
AU  - Huang, E. S.
AU  - Leon, M. B.
AU  - Shawl, F.
AU  - Finkel, T.
AU  - Epstein, S. E.
AU  - Marx, J.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1994///
VL  - 265
IS  - 5170
SP  - 391
EP  - 394
SN  - 0036-8075
AD  - Speir, E.: Cardiology Branch, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001507.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - A subset of patients who had undergone coronary angioplasty developed restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38%) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.The role of CMV-p53 in causing clogged arteries is discussed further by J. Marx (p. 320).
KW  - disease prevalence
KW  - human diseases
KW  - infections
KW  - North America
KW  - USA
KW  - cytomegalovirus
KW  - man
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - restenosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001507&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lack of evidence for the dichotomy of the TH1 and TH2 predominance in HIV-infected individuals.
AU  - Graziosi, C.
AU  - Pantaleo, G.
AU  - et al.
AU  - Gantt, K. R. (
JO  - Science, USA
JF  - Science, USA
Y1  - 1994///
VL  - 265
IS  - Jul. 8
SP  - 248
EP  - 252
AD  - Graziosi, C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942007181.  Publication Type: Journal Article.  Language: English.  Number of References: 25 notes and ref.
KW  - Cytokines
KW  - HIV infections
KW  - immune response
KW  - Immunology
KW  - interleukins
KW  - T lymphocytes
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - THl cells
KW  - THO shift
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007181&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary protein-induced renal growth: correlation between renal IGF-I synthesis and hyperplasia.
AU  - Chin, E.
AU  - Bondy, C. A.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1994///
VL  - 266
IS  - 4
SP  - C1037
EP  - C1045
SN  - 0002-9513
AD  - Chin, E.: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951405400.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 61912-98-9.  Subject Subsets: Human Nutrition
N2  - Insulin-like growth factor I (IGF-I) and IGF binding protein 1 (IGFBP-1) mRNAs are colocalized in the medullary thick ascending limb (MTAL) of the rat nephron, a segment that undergoes selective growth in response to elevated dietary protein. Rats were fed on isoenergetic diets containing variable protein content (6-40%) for 1-7 days, and changes in fractional renal weight, MTAL length and regional DNA synthesis were assayed and compared with local changes in IGF-I/IGFBP-1 mRNAs, as estimated by quantitative in situ hybridization. Rats switched to high-protein diets demonstrated increased IGF-I and decreased IGFBP-1 mRNA levels in MTALs, whereas those switched to low protein showed inverse changes. The increase in renal IGF-I mRNA was maximal at 2 days and was closely paralleled by significant increases in fractional renal weight, DNA synthesis and MTAL length. Similar changes were seen in vasopressin-deficient Brattleboro and growth hormone (GH)-deficient dwarf rats in response to high-protein diets, suggesting that the effects of dietary protein in this model are not mediated by vasopressin or GH. The close spatial and temporal correlation between changes in renal IGF-I expression and changes in regional growth parameters strongly supports a role for locally produced IGF-I in the induction of protein-induced renal growth.
KW  - binding proteins
KW  - growth
KW  - hyperplasia
KW  - hypertrophy
KW  - insulin-like growth factor
KW  - kidneys
KW  - messenger RNA
KW  - protein intake
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - mRNA
KW  - somatomedin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405400&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication.
AU  - Lori, F.
AU  - Malykh, A.
AU  - Cara, A.
AU  - Sun, D.
AU  - Weinstein, J. N.
AU  - Lisziewicz, J.
AU  - Gallo, R. C.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1994///
VL  - 266
IS  - 5186
SP  - 801
EP  - 805
SN  - 0036-8075
AD  - Lori, F.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952001051.  Publication Type: Journal Article.  Language: English.  Registry Number: 69655-05-6, 127-07-1. 
KW  - antiviral agents
KW  - combination therapy
KW  - didanosine
KW  - human immunodeficiency viruses
KW  - hydroxycarbamide
KW  - inhibition
KW  - replication
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - DNA synthesis
KW  - human immunodeficiency virus
KW  - hydroxyurea
KW  - multimodal treatment
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001051&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid and insulin secretion in pancreatic islets.
AU  - Bergsten, P.
AU  - Sanchez Moura, A.
AU  - Atwater, I.
AU  - Levine, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 2
SP  - 1041
EP  - 1045
SN  - 0021-9258
AD  - Bergsten, P.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951410460.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - The effect of ascorbic acid on glucose-induced insulin release from single pancreatic islets (from Sprague-Dawley rats) was measured using a new, ultra-sensitive enzyme-linked immunosorbent insulin assay. Within 20 s ascorbic acid inhibited insulin secretion; inhibition was dose dependent and completely reversible. There was a 50% inhibition of the secretory response with ascorbic acid 200 µM and 90% inhibition with ascorbic acid 400 µM. The decrease in insulin secretion was recorded as a reduction of the amplitudes of the fast insulin transients, which give rise to the oscillatory nature of insulin secretion. The inhibition of glucose-induced insulin release by ascorbic acid was associated with hyperpolarization of the pancreatic β-cell. Suppression of glucose-induced membrane depolarization was evident after 20 s, was dose dependent and was completely reversible. The data here may provide the first explanation of why plasma ascorbate concentrations are tightly controlled.
KW  - ascorbic acid
KW  - insulin secretion
KW  - pancreas islets
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410460&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells.
AU  - Gao, W. Y.
AU  - Agbaria, R.
AU  - Driscoll, J. S.
AU  - Mitsuya, H.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 17
SP  - 12633
EP  - 12638
SN  - 0021-9258
AD  - Gao, W. Y.: (H. Mitsuya) Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006752.  Publication Type: Journal Article.  Language: English. 
KW  - analogues
KW  - Biochemistry
KW  - human immunodeficiency viruses
KW  - Metabolism
KW  - nucleoside analogues
KW  - nucleosides
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - analogs
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006752&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of phosphorylation and nucleotides on the conformation of myosin II from Acanthamoeba castellanii.
AU  - Redowicz, M. J.
AU  - Martin, B.
AU  - Zolkiewski, M.
AU  - Ginsburg, A.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 18
SP  - 13558
EP  - 13563
SN  - 0021-9258
AD  - Redowicz, M. J.: Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803490.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activity of filamentous Acanthamoeba castellanii myosin II is inactivated by phosphorylation of a short non-helical tailpiece at the C-terminal end of each heavy chain, even though the catalytic sites are in the N-terminal globular head. Consistent with this effect, phosphorylation at the tip of the tail alters the conformation of the head, as shown by a shift in the principal site of cleavage by endoproteinase Arg-C. It was shown that the sedimentation coefficient of monomeric phospho-myosin II is 1.3-4.6% lower than that of dephospho-myosin II, which suggests that phosphorylation produces a less compact conformation with a small increase in frictional coefficient. Changes in papain digestion patterns showed that bound nucleotide also affects the conformation of the head region of monomeric phospho- and dephospho-myosin II, the conformation of the head region of filamentous phospho- and dephospho-myosin II, and the conformation of the C-terminal region of the tail of filamentous phospho-myosin II. Conformational differences between the dephospho- and phospho-forms of myosin II in the presence of nucleotide, as detected by susceptibility to proteolysis appear to be greater in filaments than in monomers. These results provide additional evidence for communication between the N-terminal heads and C-terminal tails of Acanthamoeba myosin II.
KW  - biochemistry
KW  - myosins
KW  - nucleotides
KW  - parasites
KW  - phosphorylation
KW  - proteins
KW  - Acanthamoeba castellanii
KW  - Acanthamoebidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803490&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium falciparumS-adenosylhomocysteine hydrolase: cDNA identification, predicted protein sequence, and expression in Escherichia coli.
AU  - Creedon, K. A.
AU  - Rathod, P. K.
AU  - Wellems, T. E.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 23
SP  - 16364
EP  - 16370
SN  - 0021-9258
AD  - Creedon, K. A.: Laboratory of Malaria Research, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950809088.  Publication Type: Journal Article.  Language: English.  Number of References: 66 ref. Subject Subsets: Protozoology
N2  - Compounds that specifically inhibit S-adenosylhomocysteine hydrolase (SAHH; EC 3.3.1.1) interfere with the proliferation of Plasmodium falciparum but efforts to identify the enzyme directly in parasite extracts have been unsuccessful. Genetic and biochemical evidence is presented for the presence of a gene encoding P. falciparum SAHH. The gene was transcribed as a 2.8 kilobase mRNA in erythrocytic stage parasites. Analysis of the open reading frame predicted a 53 900 MW protein having conserved regions thought to be involved in NAD binding. The cDNA sequence was incorporated into an Escherichia coli expression construct to confirm the function of the sahh product. Transformed E. coli cells produced a protein with a relative molecular weight of 56 000 which possessed SAHH activity, as evidenced by the conversion of 3-deazaadenosine to S-3-deazaadenosylhomocysteine. Several amino acid residues that have been suggested to be at the SAHH active site in other organisms show nonconserved replacements in P. falciparum, suggesting that some current proposals for the enzyme mechanism may need to be revised. Structural differences between P. falciparum and mammalian SAHH enzymes may foster innovative strategies for antimalarial drug development.
KW  - biochemistry
KW  - complementary dna
KW  - enzyme inhibitors
KW  - enzymes
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - adenosylhomocysteine hydrolase
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809088&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Removal of zinc is required for processing of the mature nucleocapsid protein of human immunodeficiency virus, type 1, by the viral protease.
AU  - Wondrak, E. M.
AU  - Sakaguchi, K.
AU  - Rice, W. G.
AU  - Kun, E.
AU  - Kimmel, A. R.
AU  - Louis, J. M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 35
SP  - 21948
EP  - 21950
SN  - 0021-9258
AD  - Wondrak, E. M.: (J.M. Louis) Building 6, Room B1-16, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952000148.  Publication Type: Journal Article.  Language: English. 
KW  - biochemistry
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - nucleocapsid proteins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - protease cleavage
KW  - protein processing
KW  - zinc finger domain
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000148&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The collagen binding domain of fibronectin contains a high affinity binding site for Candida albicans.
AU  - Nègre, E.
AU  - Vogel, T.
AU  - Levanon, A.
AU  - Guy, R.
AU  - Walsh, T. J.
AU  - Roberts, D. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 35
SP  - 22039
EP  - 22045
SN  - 0021-9258
AD  - Nègre, E.: Laboratory of Pathology and Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951203147.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A 30-kDa proteolytic fragment from the gelatin/collagen binding domain of fibronectin was a potent inhibitor of fibronectin binding to C. albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin-I and the heparin II-binding domains also inhibited fibronectin binding but were 13- to 1000-fold less active. In suspension, binding of fibronectin to C. albicans was regulated by growth conditions and is specific, saturable, time-dependent, reversible and divalent cation-independent. Scatchard-plot analyses indicated the presence of high affinity (Kd=1.3 × 10-9M) and low affinity (Kd=1.2 × 10-7M) receptors. Recombinant or proteolytic fragments from 4 binding domains of fibronectin promoted adhesion of C. albicans. A recombinant fragment corresponding to the cell-binding domain but with the sequence Arg-Gly-Asp-Ser deleted promoted C. albicans adhesion and inhibited fibronectin binding to C. albicans with the same activity as the natural sequence. Four peptides containing the Arg-Gly-Asp sequence and the peptides CS-1 and Arg-Glu-Asp-Val did not block the binding of fibronectin to C. albicans. It is suggested that, in contrast to the specific binding of soluble fibronectin, recognition of immobilized fibronectin by C. albicans is mediated by several domains of the protein. Interactions with the cell-binding domain are not mediated by the Arg-Gly-Asp or other known recognition sequences. Binding of fibronectin did not correlate with C3d binding to the avirulent clones of C. albicans strain H12 or with iC3b binding to variants of the strain 4918.
KW  - adhesion
KW  - fibronectins
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203147&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.
AU  - Kruth, H. S.
AU  - Skarlatos, S. I.
AU  - Gaynor, P. M.
AU  - Gamble, W.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 39
SP  - 24511
EP  - 24518
SN  - 0021-9258
AD  - Kruth, H. S.: Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951413329.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Atherosclerotic lesions have a lipid core containing crystals and liposomes enriched in unesterified cholesterol as well as numerous monocyte-macrophages enriched in cholesteryl ester. Sufficient amounts of plasma-derived HDL may not reach and efficiently remove the cholesterol deposited in lesion macrophages or in the lipid core of lesions. The potential of human monocyte-macrophages to produce nascent HDL and to solubilize cholesterol derived from interaction of monocyte-macrophages with lipoprotein and non-lipoprotein sources of cholesterol was examined. Monocyte-macrophages produced discoidal (25±6 nm long and 6±1 nm wide (mean±s.d.)) and vesicular (89±41 nm in diameter) lipoprotein particles following and during enrichment of macrophages with cholesterol from acetylated LDL (AcLDL) or cholesterol crystals. During cholesterol enrichment, discoidal particles progressively accumulated in the medium for up to 6 days. In contrast, vesicles did not increase past 2 days of incubation. Both the discoidal and vesicular lipoprotein particles had a peak density of about 1.09-1.10 g/ml. The discoidal particles contained apolipoprotein E (apoE), whereas vesicles contained a major protein constituent with a molecular mass of 22 000 daltons. The vesicles did not contain detectable apoE and the 22 000-dalton protein was not the 22 000-dalton thrombolytic fragment of apoE. Following cholesterol enrichment of macrophages with AcLDL or cholesterol crystals, macrophages excreted much of their accumulated cholesterol, even in the absence of exogenously added cholesterol acceptors. Most of this excreted cholesterol was recovered from the culture medium and was carried in the apoE discoidal particles that showed cholesterol enrichment up to a 2:1 unesterified cholesterol to phospholipid molar ratio. Findings suggest that sufficient production of these nascent HDL by macrophages within atherosclerotic lesions should facilitate removal of cellular and extracellular cholesterol, even in the absence of plasma-derived HDL.
KW  - cell cultures
KW  - cholesterol
KW  - high density lipoprotein
KW  - macrophages
KW  - synthesis
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413329&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The influence of DNA and nucleosome structure on integration events directed by HIV integrase.
AU  - Pruss, D.
AU  - Reeves, R.
AU  - Bushman, F. D.
AU  - Wolffe, A. P.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 40
SP  - 25031
EP  - 25041
SN  - 0021-9258
AD  - Pruss, D.: Laboratory of Molecular Embryology, NICHHD, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002108.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - histones
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - integration
KW  - molecular biology
KW  - structure
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - integrase
KW  - nucleosome
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002108&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase.
AU  - Hickman, A. B.
AU  - Palmer, I.
AU  - Engelman, A.
AU  - Craigie, R.
AU  - Wingfield, P.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1994///
VL  - 269
IS  - 46
SP  - 29279
EP  - 29287
SN  - 0021-9258
AD  - Hickman, A. B.: Office of the Director, Protein Expression Laboratory National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002117.  Publication Type: Journal Article.  Language: English.  Number of References: 66 ref.
KW  - catalytic activity
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - mutations
KW  - structure
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002117&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood.
AU  - Clerici, M.
AU  - Levin, J. M.
AU  - et al.
AU  - Kessler, H. A. (
AU  - Shearer, G. M.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 271
IS  - 1
SP  - 42
EP  - 46
SN  - 0098-7484
AD  - Clerici, M.: (G.M. Shearer) National Cancer Institute, National Institutes of Health, Experimental Immunology Branch, Building 10, Room 4B17, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005341.  Publication Type: Journal Article.  Language: English. 
KW  - cell mediated immunity
KW  - Health care workers
KW  - HIV infections
KW  - Immune response
KW  - Immunology
KW  - T lymphocytes
KW  - cellular immunity
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Percutaneous exposure
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Health Services (UU350) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005341&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ocular toxoplasmosis: an old disease revisited.
AU  - Nussenblatt, R. B.
AU  - Belfort, R., Jr.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 271
IS  - 4
SP  - 304
EP  - 305
SN  - 0098-7484
AD  - Nussenblatt, R. B.: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950809265.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Protozoology
N2  - A general account of the clinical manifestations and diagnosis of ocular toxoplasmosis is given, with details of 2 selected cases (a 2-year-old Brazilian infant and a 20-year-old American man). It is emphasized that in immunodeficient patients the signs of ocular toxoplasmosis can be similar to those noted in immunocompetent patients, although multiple active lesions may be seen in both eyes which is rarely seen in patients that are not immunosuppressed. In patients with the acquired immune deficiency syndrome (AIDS), the development of ocular toxoplasmosis usually occurs before cytomegalovirus (CMV) retinitis. Exacerbations of the ocular disease are not predictable, although they are more frequent in the years immediately following the first episode and then occur less commonly with time.
KW  - case reports
KW  - diagnosis
KW  - eye diseases
KW  - eyes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - pathology
KW  - reviews
KW  - symptoms
KW  - toxoplasmosis
KW  - Brazil
KW  - USA
KW  - cytomegalovirus
KW  - man
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809265&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - HIV-2 transmission: implications for spread of HIV-1.
AU  - O'Brien, T. R.
T2  - JAMA, Journal of the American Medical Association
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 271
IS  - 12
SP  - 903
EP  - 904
SN  - 0098-7484
AD  - O'Brien, T. R.: National Cancer Institute, Rockville, Maryland, USA.
N1  - Accession Number: 19942006764.  Publication Type: Correspondence.  Language: English. 
KW  - Epidemiology
KW  - HIV infections
KW  - Infectivity
KW  - Sexual transmission
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus infections
KW  - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
KW  - HUMAN IMMUNODEFICIENCY VIRUS TYPE 2
KW  - venereal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006764&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body mass index, weight change and risk of mobility disability in middle-aged and older women. The epidemiologic follow-up study of NHANES I.
AU  - Launer, L. J.
AU  - Harris, T.
AU  - Rumpel, C.
AU  - Madans, J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 271
IS  - 14
SP  - 1091
EP  - 1098
SN  - 0098-7484
AD  - Launer, L. J.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Gateway Bldg 3C-309, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951403587.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - The relation between body mass index (BMI), weight change and the onset of disability in older women was studied. White women were classified as young-old (mean age 60 years at baseline, mean age 65 years at follow-up) and old-old (mean age 76 years at baseline, mean age 80 years at follow-up). The main outcome measures were the relative odds for the onset of mobility disability associated with tertiles of past BMI (measured 6-8 years prior to disability ascertainment) and current BMI (measured 2-5 years prior to disability ascertainment) and with weight change between the 2 weight measurements. The prospective data suggested that high BMI is a strong predictor of long-term risk for mobility disability in older women and that this risk persists even to very old age. However, the paradoxical increase in risk associated with weight loss observed in the old-old women requires further study. Programmes to prevent overweight may have potential for decreasing disability in women.
KW  - age
KW  - body weight
KW  - disabilities
KW  - middle age
KW  - old age
KW  - overweight
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403587&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Helicobacter pylori in peptic ulcer disease.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 272
IS  - 1
SP  - 65
EP  - 69
SN  - 0098-7484
AD  - Office of Medical Applications of Research, Federal Building, Room 618, National Institutes of Health, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962004195.  Publication Type: Journal Article; Conference paper; Journal article.  Corporate Author: NIH Consensus Development Panel on Helicobacter pylori in Peptide Ulcer Disease. Language: English. 
N2  - The National Institutes of Health Consensus Development Conference on Helicobacter pylori in Peptic Ulcer Disease brought together specialists on gastroenterology, surgery, infectious diseases, epidemiology, and pathology, as well as the public to address the following questions: (1) What is the causal relationship of H. pylori to upper gastrointestinal disease? (2) How does one diagnose and eradicate H. pylori infection? (3) Does eradication of H. pylori infection benefit the patient with peptic ulcer disease? (4) What is the relationship between H. pylori infection and gastric malignancy? (5) Which H. pylori-infected patients should be treated? (6) What are the most important questions that must be addressed by future research in H. pylori infections? Following 11/2 days of presentations by experts and discussion by the audience, a consensus panel weighted the evidence and prepared their consensus statement. Among their findings, the consensus panel concluded that (1) ulcer patients with H. pylori infection require treatment with antimicrobial agents in addition to antisecretory drugs whether on first presentation with the illness or on recurrence; (2) the value of treating of non-ulcerative dyspepsia patients with H. pylori infection remains to be determined; and (3) the interesting relationship between H. pylori infection and gastric cancers requires further exploration.
KW  - human diseases
KW  - infections
KW  - peptic ulcers
KW  - Helicobacter pylori
KW  - man
KW  - Helicobacter
KW  - Helicobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004195&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Weight cycling.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 272
IS  - 15
SP  - 1196
EP  - 1201
SN  - 0098-7484
AD  - Division of Digestive Diseases and Nutrition, National Institutes of Health, Bldg 31, Room 9A23, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951408255.  Publication Type: Journal Article.  Corporate Author: USA, National Task Force on the Prevention and Treatment of Obesity Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
N2  - A metaanalysis of weight cycling, "yo-yo dieting" and weight fluctuation was undertaken and led to the following conclusions. There is no convincing evidence that weight cycling in man has adverse effects on body composition, energy expenditure, risk factors for cardiovascular disease, or the effectiveness of future efforts at weight loss. Evidence regarding increased morbidity and mortality with variation in body weight is not sufficiently compelling to override the potential benefits of moderate weight loss in significantly obese patients. Determination of the psychological impact of weight cycling requires further investigation. Non-obese individuals should focus on preventing of weight gain by means of exercise and appropriate diet. Obese individuals who undertake weight loss efforts should be ready to commit themselves to lifelong changes in lifestyle and diet.
KW  - body weight
KW  - cycling
KW  - health
KW  - obesity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - metaanalysis
KW  - nutrient cycling
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408255&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Survival and disease progression according to gender of patients with HIV infection. The Terry Beirn Community Programs for clinical research on AIDS.
AU  - Melnick, S. L.
AU  - Sherer, R.
AU  - Louis, T. A.
AU  - Hillman, D.
AU  - Rodriguez, E. M.
AU  - Lackman, C.
AU  - Capps, L.
AU  - Brown, L. S. Jr
AU  - Carlyn, M.
AU  - Korvick, J. A.
AU  - Deyton, L.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1994///
VL  - 272
IS  - 24
SP  - 1915
EP  - 1921
SN  - 0098-7484
AD  - Melnick, S. L.: Epidemiology Branch, Division of AIDS, National Institutes of Health, 6003 Executive Blvd, Room 2C09, MSC 7620, Bethesda, MD 20892-7620, USA.
N1  - Accession Number: 19952008213.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
KW  - disease course
KW  - gender relations
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mortality
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - death rate
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008213&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Insulin stimulation of glucose transport activity in rat skeletal muscle: increase in cell surface GLUT4 as assessed by photolabelling.
AU  - Wilson, C. M.
AU  - Cushman, S. W.
JO  - Biochemical Journal (London)
JF  - Biochemical Journal (London)
Y1  - 1994///
VL  - 299
IS  - 3
SP  - 755
EP  - 759
SN  - 0264-6021
AD  - Wilson, C. M.: Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951406682.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 50-99-7, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - A photoaffinity label was used to quantify cell surface GLUT4 glucose transporters in isolated rat soleus muscles. In this system, insulin stimulated an 8.6-fold increase in 3-O-methylglucose glucose transport, while photolabelled GLUT4 increased 8-fold. These results demonstrate that the insulin-stimulated increase in glucose transport activity in skeletal muscle can be accounted for by an increase in surface-accessible GLUT4 content.
KW  - glucose
KW  - insulin
KW  - metabolism
KW  - skeletal muscle
KW  - transport
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dextrose
KW  - transportation
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low cholesterol concentrations and severe depressive symptoms in elderly people.
AU  - Brown, S. L.
AU  - Salive, M. E.
AU  - Harris, T. B.
AU  - Simonsick, E. M.
AU  - Guralnik, J. M.
AU  - Kohout, F. J.
JO  - British Medical Journal (Clinical Research edition)
JF  - British Medical Journal (Clinical Research edition)
Y1  - 1994///
VL  - 308
IS  - 6940
SP  - 1328
EP  - 1332
SN  - 0959-8138
AD  - Brown, S. L.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951405957.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The reported association between low serum cholesterol concentration and severe depressive symptoms was examined in 3939 men and women ≥71 years old. All analyses were stratified by sex, and multivariate analyses were adjusted for age, self-reported health, physical function, number of drugs used and weight loss. The score of depressive symptoms on the Centers for Epidemiologic Studies' depression scale was used to quantify depression. Depressive symptoms, cholesterol concentration, weight and use of drugs were all associated with age in men and women. The relative odds of severe depressive symptoms (score ≥16) for those with low cholesterol concentrations (&lt;4.14 mmol/litre) were 1.9 (95% confidence interval 1.1 to 3.3) for the older group of men and 1.8 (1.1 to 2.9) for the older group of women. This association was also observed when depressive symptoms were analysed as a continuous rather than a categorical variable. In multivariate models that adjusted for age, self-reported health, physical function, number of drugs used and weight loss, the association was substantially weakened. After several factors relating to health had been controlled for, no significant association between low cholesterol concentration and severe depressive symptoms was found.
KW  - blood
KW  - cholesterol
KW  - depression
KW  - drug therapy
KW  - health
KW  - mental disorders
KW  - old age
KW  - weight losses
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - mental illness
KW  - psychiatric disorders
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405957&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Accumulation of fatty alcohol in MCF-7 breast cancer cells.
AU  - Welsh, C. J.
AU  - Robinson, M.
AU  - Warne, T. R.
AU  - Pierce, J. H.
AU  - Yeh, G. C.
AU  - Phang, J. M.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1994///
VL  - 315
IS  - 1
SP  - 41
EP  - 47
SN  - 0003-9861
AD  - Welsh, C. J.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
N1  - Accession Number: 19950400097.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Dairy Science
KW  - epithelium
KW  - fatty alcohols
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mammary tumour
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950400097&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli.
AU  - Tipper, J. P.
AU  - Citron, B. A.
AU  - Ribeiro, P.
AU  - Kaufman, S.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1994///
VL  - 315
IS  - 2
SP  - 445
EP  - 453
SN  - 0003-9861
AD  - Tipper, J. P.: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950103118.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9037-21-2.  Subject Subsets: Agricultural Biotechnology
N2  - Tryptophan hydroxylase was cloned from rabbit and human, and expressed in Escherichia coli (EMBL/GenBank accession number L29305 and L29306 respectively). Each of the cDNAs, including the complete coding sequence of tryptophan hydroxylase, was obtained by reverse transcription of rabbit or human brain mRNA and subcloned into the expression vector pET-3C. The expressed rabbit brain tryptophan hydroxylase activity, measured in the presence of tetrahydrobiopterin, represents approximately a 50-fold enhancement in yield (units/g tissue (wet wt)) over that of a rabbit brain extract. The level of expressed human brain tryptophan hydroxylase was approximately 57-fold the average yield previously reported for a human brain homogenate and approximately 10-fold the activity of homogenates of human raphe nucleus. The rabbit brain and pineal-derived tryptophan hydroxylase sequences varied by disparities in 6 amino acid residues (99% identity). The human carcinoid and brain peptide sequences varied by disparities in 18 amino acid residues (96% identity). Several properties of both expressed enzymes were studied and compared with those of native tryptophan hydroxylases.
KW  - biotechnology
KW  - brain
KW  - gene expression
KW  - nucleotide sequences
KW  - tryptophan 5-monooxygenase
KW  - Escherichia coli
KW  - man
KW  - rabbits
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - bacterium
KW  - cerebrum
KW  - cloning
KW  - DNA sequences
KW  - E. coli
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950103118&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Interferon therapy for chronic viral hepatitis.
AU  - Bisceglie, A. M. di
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1994///
VL  - 330
IS  - 2
SP  - 137
EP  - 138
SN  - 0028-4793
AD  - Bisceglie, A. M. di: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005889.  Publication Type: Editorial.  Language: English.  Number of References: 10 ref. Registry Number: 9008-11-1. 
KW  - editorials
KW  - hepatitis
KW  - human diseases
KW  - immunotherapy
KW  - interferon
KW  - viral diseases
KW  - viral hepatitis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005889&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection.
AU  - Abrams, D. I.
AU  - Goldman, A. I.
AU  - et al.
AU  - Launer, C. (
AU  - Deyton, L.\Saag, M. S.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1994///
VL  - 330
IS  - 10
SP  - 657
EP  - 662
SN  - 0028-4793
AD  - Abrams, D. I.: (L. Deyton) National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005816.  Publication Type: Journal Article.  Corporate Author: USA, Terry Beirn Community Programs for Clincal Research on AIDS Language: English.  Registry Number: 30516-87-1. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Clinical aspects
KW  - HIV infections
KW  - Treatment
KW  - Zidovudine
KW  - AIDS
KW  - AZT
KW  - clinical picture
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005816&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Declining age at HIV infection in the United States.
AU  - Rosenberg, P. S.
AU  - Biggar, R. J.
AU  - Goedert, J. J.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1994///
VL  - 330
IS  - 11
SP  - 789
EP  - 789
SN  - 0028-4793
AD  - Rosenberg, P. S.: National Cancer Institute, Rockville, MD 20892, USA.
N1  - Accession Number: 19942005819.  Publication Type: Correspondence.  Language: English.  Subject Subsets: Public Health
N2  - Analysis by "back-calculation" of data on the incidence of AIDS in the USA through 1991 showed that the total number of new infections declined from peak levels in the mid-1980s to about 50 000-60 000 new infections per year from 1987-91. The estimated median age at time of infection declined from more than 30 years in the early 1980s to 25 years from 1987-91. During this latter period 1 of every 4 people newly infected with HIV was younger than 22.Hilary Richardson
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Age
KW  - age determination
KW  - Epidemiology
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - infections
KW  - North America
KW  - USA
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - Human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005819&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease.
AU  - Klahr, S.
AU  - Levey, A. S.
AU  - Beck, G. J.
AU  - Caggiula, A. W.
AU  - Hunsicker, L.
AU  - Kusek, J. W.
AU  - Striker, G.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1994///
VL  - 330
IS  - 13
SP  - 877
EP  - 884
SN  - 0028-4793
AD  - Klahr, S.: National Instittue of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19951406382.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. This was investigated in 840 patients with various chronic renal diseases. In study 1, 585 patients with glomerular filtration rates of 25 to 55 ml min-1 1.73 m-2 of body-surface area were randomly assigned to a usual-protein diet or a low-protein diet (protein 1.3 or 0.58 g/kg body weight daily) and to a usual- or a low-blood-pressure group (mean arterial pressure, 107 or 92 mm Hg). In study 2, 255 patients with glomerular filtration rates of 13 to 24 were randomly assigned to the low-protein diet (0.58 g/kg daily) or a very-low-protein diet (0.28 g/kg daily) with a keto acid-amino acid supplement and a usual- or a low-blood-pressure group (same values as those in study 1). An 18-to-45-month follow-up was planned, with monthly evaluations of the patients. The mean follow-up was 2.2 years. In study 1, the projected mean decline in the glomerular filtration rate at 3 years did not differ significantly between the diet groups or between the blood-pressure groups. As compared with the usual-protein group and the usual-blood-pressure group, the low-protein group and the low-blood-pressure group had a more rapid decline in the glomerular filtration rate during the first 4 months after randomization and a slower decline thereafter. In study 2, the very-low-protein group had a marginally slower decline in the glomerular filtration rate than did the low-protein group (P=0.07). There was no delay in the time to the occurrence of end-stage renal disease or death. In both studies, patients in the low-blood-pressure group who had more pronounced proteinuria at base line had a significantly slower rate of decline in the glomerular filtration rate. Among patients with moderate renal insufficiency, the slower decline in renal function that started 4 months after the introduction of a low-protein diet suggests a small benefit of this dietary intervention. Among patients with more severe renal insufficiency, a very-low-protein diet, as compared with a low-protein diet, did not significantly slow the progression of renal disease.
KW  - blood pressure
KW  - control
KW  - inhibition
KW  - kidney diseases
KW  - protein deprivation
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - kidney disorders
KW  - nephropathy
KW  - renal diseases
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406382&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Elucidation of the poly-L-proline binding site in Acanthamoeba profilin I by NMR spectroscopy.
AU  - Archer, S. J.
AU  - Vinson, V. K.
AU  - Pollard, T. D.
AU  - Torchia, D. A.
JO  - FEBS Letters
JF  - FEBS Letters
Y1  - 1994///
VL  - 337
IS  - 2
SP  - 145
EP  - 151
SN  - 0014-5793
AD  - Archer, S. J.: Bone Research Branch, Building 30, Room 106, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950801113.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology
N2  - The multifunctional protein profilin is thought to regulate actin assembly and the phosphoinositide signaling pathway. Profilin binds to several different ligands including actin, poly-L-proline, and the head groups of polyphosphoinositides. As a preliminary step in the characterization of profilin/ligand complexes, a profilin/poly-L-proline complex in solution was studied using high resolution nuclear magnetic resonance spectroscopy. Analysis of profilin nuclear Overhauser effects and chemical shift data indicated that the protein secondary structure was conserved upon binding to poly-L-proline and that the binding site was located between the N- and C-terminal helices in a region rich in highly conserved aromatic side chains. This site is adjacent to the proposed binding site for actin. In addition, the rate constant for dissociation of the complex was found to be 1.6 ± 0.2 x 104/second.
KW  - BINDING SITES
KW  - biochemistry
KW  - nuclear magnetic resonance
KW  - parasites
KW  - proteins
KW  - Acanthamoeba
KW  - protozoa
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - binding site
KW  - polyprolines
KW  - profilins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801113&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic analysis of Creutzfeldt-Jakob disease and related disorders.
AU  - Goldfarb, L. G.
AU  - Brown, P.
AU  - Cervenakova, L.
AU  - Gajdusek, D. C.
JO  - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
JF  - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Y1  - 1994///
VL  - 343
IS  - 1306
SP  - 379
EP  - 384
SN  - 0962-8436
AD  - Goldfarb, L. G.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19942027999.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health; Tropical Diseases
N2  - Genetic studies of over 200 cases of Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru have brought a reliable body of evidence that the familial forms of CJD and all known cases of GSS and FFI are linked to germline mutations in the coding region of the PRNP [normal host prion protein] gene on chromosome 20, either point substitutions or expansion of the number of 24-nucleotide repeat units. Phenotypic expression of FFI and familial CJD, clinically and pathologically distinct syndromes linked to the 178Asp-&gt;Asn substitution, is dependent on a polymorphism at codon 129. Synthetic peptides homologous to several regions of PrP spontaneously form insoluble amyloid fibrils with unique morphological characteristics and polymerization tendencies. Peptides homologous to mutated regions of PrP exhibit enhanced fibrillogenic properties and, if mixed with the wild-type peptide, produce even more abundant and larger fibrous aggregates. A similar process in vivo may be the primary event leading to amyloid accumulation and disease. AS
KW  - Creutzfeldt-Jakob disease
KW  - molecular genetics
KW  - biochemical genetics
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027999&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Long-term effect of prenatal exposure to maternal microfilaraemia on immune responsiveness to filarial parasite antigens.
AU  - Steel, C.
AU  - Guinea, A.
AU  - McCarthy, J. S.
AU  - Ottesen, E. A.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1994///
VL  - 343
IS  - 8902
SP  - 890
EP  - 893
SN  - 0140-6736
AD  - Steel, C.: Laboratory of Parasitic Diseases, Building 4 Room 126, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19952003192.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Tropical Diseases; Helminthology
N2  - To identify long-term effects of prenatal exposure to maternal filarial-parasite infection, the authors assessed lymphocyte responses in 21 Polynesian children born 17-19 years previously to mothers diagnosed as being microfilaraemic or infection-free. All children lived on an island endemic for Wuchereria bancrofti filariasis but were free from infection at the time of study. While children (n = 10) of infection-free mothers responded vigorously to microfilarial antigen with lymphocyte proliferation, production of interleukin 2 (IL-2), IL-5, IL-10, granulocyte macrophage colony-stimulating factor (GM-CSF), and interferon γ (IFN-γ), cellular hyporesponsiveness was seen in children (n = 11) born to microfilaraemic mothers. The hyporesponsiveness appeared restricted to microfilarial antigens and did not extend to non-parasite antigens. These findings suggest that hyporesponsiveness resulted from in-utero acquisition of tolerance to microfilarial antigens in chronically-infected mothers.
KW  - antigens
KW  - children
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - infections
KW  - maternal immunity
KW  - parasites
KW  - Oceania
KW  - Polynesia
KW  - man
KW  - Nematoda
KW  - Onchocercidae
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Wuchereria
KW  - Onchocercidae
KW  - Oceania
KW  - Pacific Islands
KW  - antigenicity
KW  - immunogens
KW  - nematodes
KW  - newborn immunity
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - vitelline immunity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003192&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Congenital anaemia after transplacental B19 parvovirus infection.
AU  - Brown, K. E.
AU  - Green, S. W.
AU  - Mayolo, J. A. de
AU  - Bellanti, J. A.
AU  - Smith, S. D.
AU  - Smith, T. J.
AU  - Young, N. S.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1994///
VL  - 343
IS  - 8902
SP  - 895
EP  - 896
SN  - 0140-6736
AD  - Brown, K. E.: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952002879.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Public Health
N2  - The authors report from Maryland, USA, 3 children with congenital anaemia after intrauterine infection with parvovirus B19. All the fetuses developed hydrops fetalis that was treated by blood transfusion. After delivery the infants had hypogammaglobulinaemia. In all 3, sera lacked B19 but viral DNA was found in bone marrow. All were treated with immunoglobulin. One child died and B19 was found in various tissues. In the other 2 cases, virus could no longer be detected after therapy but the patients remain persistently anaemic. Persistent B19 infection should be suspected in infants with congenital red-cell aplasia.
KW  - case reports
KW  - congenital infection
KW  - human diseases
KW  - infants
KW  - infections
KW  - neonates
KW  - Maryland
KW  - North America
KW  - USA
KW  - man
KW  - parvovirus B19
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Parvovirus
KW  - Parvoviridae
KW  - ssDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - newborn infants
KW  - prenatal infection
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002879&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tuberculosis in eastern Europe and the former Soviet Union: how concerned should we be?
AU  - Burns, D. N.
AU  - Gellert, G. A.
AU  - Crone, R. K.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1994///
VL  - 343
IS  - 8911
SP  - 1445
EP  - 1446
SN  - 0140-6736
AD  - Burns, D. N.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19952001510.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - The authors review the changing incidence of tuberculosis (TB). Since the late 1980s the steady decline in TB began to level off and in many countries the trend was actually reversed. In eastern Europe this is thought to be a result of malnutrition, poor living conditions and inadequate supplies of antituberculosis drugs. Human immunodeficiency virus (HIV) may play a role in the future. In 1993 the WHO declared the resurgence of TB a global emergency and published new treatment guidelines.
KW  - disease prevalence
KW  - human diseases
KW  - risk factors
KW  - tuberculosis
KW  - Central europe
KW  - Europe
KW  - USSR
KW  - man
KW  - Mycobacterium tuberculosis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Europe
KW  - bacterium
KW  - Union of Soviet Socialist Republics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001510&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes.
AU  - Straus, S. E.
AU  - Corey, L.
AU  - Burke, R. L.
AU  - Savarese, B.
AU  - Barnum, G.
AU  - Krause, P. R.
AU  - Kost, R. G.
AU  - Meier, J. L.
AU  - Sekulovich, R.
AU  - Adair, S. F.
AU  - Dekker, C. L.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1994///
VL  - 343
IS  - 8911
SP  - 1460
EP  - 1463
SN  - 0140-6736
AD  - Straus, S. E.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N-228, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952001511.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Immunotherapy of chronic viral diseases with vaccines is an important but unproven concept. The authors investigated the effect of a vaccine containing recombinant glycoprotein D (gD2) of herpes simplex virus type 2 (HSV-2) on the frequency of symptomatic outbreaks in patients with genital herpes. 98 patients with documented genital herpes who reported 4-14 recurrences per year were enrolled in a double-blind, placebo-controlled trial. Subjects received injections of either 100 µg gD2 in alum or alum alone (placebo) at 0 and 2 months and recurrences were documented for 1 year. The vaccine was well tolerated. gD2 recipients reported fewer recurrences per month than placebo recipients (mean 0.42 [SE 0.05] vs. 0.55 [0.05]; P = 0.055), had fewer virologically confirmed recurrences per month (0.18 [0.03] vs. 0.28 [0.03]; P = 0.019), and had a lower median number of recurrences for the study year (4 [range 0-17] vs. 6 [0-15]; P = 0.039). Neither genital recurrences not the placebo vaccine had any discernible effect on HSV-2-specific antibody responses, but gD2 vaccine boosted neutralizing antibodies to HSV-2 fourfold and gD2-specific titres sevenfold over baseline levels. These results inspire optimism about the potential use of vaccine for the treatment of chronic, recurring viral diseases.
KW  - clinical trials
KW  - human diseases
KW  - immunization
KW  - immunotherapy
KW  - recombinant vaccines
KW  - North America
KW  - USA
KW  - Human herpesvirus 2
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - herpes simplex virus 2
KW  - immune sensitization
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High incidence of anal cancer among AIDS patients.
AU  - Melbye, M.
AU  - Coté, T. R.
AU  - Kessler, L.
AU  - Gail, M.
AU  - Biggar,R. J.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1994///
VL  - 343
IS  - Mar. 12
SP  - 636
EP  - 639
SN  - 0140-6736
AD  - Melbye, M.: (T.R. Coté) Viral Epidemiology Branch, National Cancer Institute (NCI), EPN-434, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19942005812.  Publication Type: Journal Article.  Corporate Author: USA, AIDS/Cancer Working Group Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - anus
KW  - Epidemiology
KW  - homosexuality
KW  - men
KW  - neoplasms
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cancers
KW  - homosexuals
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - PCP prophylaxis in paediatric HIV infection: time for a change?
AU  - Kovacs, J. A.
AU  - Kovacs, A. A. S.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1994///
VL  - 344
IS  - July 2
SP  - 5
EP  - 6
SN  - 0140-6736
AD  - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19942006936.  Publication Type: Journal Article.  Language: English. 
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - Clinical aspects
KW  - HIV infections
KW  - Paediatrics
KW  - Pneumocystis carinii pneumonia
KW  - Prophylaxis
KW  - AIDS
KW  - clinical picture
KW  - human immunodeficiency virus infections
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis.
AU  - Warburg, A.
AU  - Saraiva, E.
AU  - Lanzaro, G. C.
AU  - Titus, R. G.
AU  - Neva, F.
JO  - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
JF  - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Y1  - 1994///
VL  - 345
IS  - 1312
SP  - 223
EP  - 230
SN  - 0962-8436
AD  - Warburg, A.: Laboratory of Malaria Research and Laboratory of Parasitic Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950503627.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Leishmania donovani chagasi [L. infantum chagasi] parasites, transmitted by sandflies of the Lutzomyia longipalpis species complex, normally cause visceral leishmaniasis. However, in Central America infections frequently result in cutaneous disease. Experiments were undertaken to investigate the possible influence of sandfly saliva on the course of infection in humans. Erythemas caused by feeding sandflies correlated well with the levels of the erythema-inducing peptide, maxadilan, in their saliva. Saliva of Brazilian flies was the most potent, that of Colombian flies less so, and Costa Rican saliva had very little maxadilan and lacked activity. Nucleotide sequence differences in the maxadilan gene of the 3 species were detected by 'single strand conformational polymorphism' electrophoresis. Leishmania infections proliferated fastest when coinjected with the saliva of Costa Rican flies. Brazilian flies had less influence, and Colombian flies only a slight effect. Thus Costa Rican Lutzomyia longipalpis, vectors of non-ulcerative cutaneous disease, have very low vasodilatory activity and very little maxadilan, but their saliva strongly enhances cutaneous proliferation of Leishmania infections. Conversely, flies from Colombia and Brazil, vectors of visceral disease, have more maxadilan, but exacerbate cutaneous infections to a lesser degree. These coincidental observations suggest that species of Lutzomyia longipalpis differ in their propensity to modulate the pathology of the disease they transmit.
KW  - biochemistry
KW  - cutaneous leishmaniasis
KW  - disease transmission
KW  - disease vectors
KW  - genes
KW  - human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - saliva
KW  - sibling species
KW  - transmission
KW  - visceral leishmaniasis
KW  - Brazil
KW  - Colombia
KW  - Costa Rica
KW  - Diptera
KW  - Leishmania infantum
KW  - Leishmania infantum chagasi
KW  - Lutzomyia longipalpis
KW  - man
KW  - Phlebotominae
KW  - protozoa
KW  - Psychodidae
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Leishmania infantum
KW  - Lutzomyia
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Andean Group
KW  - CACM
KW  - Central America
KW  - biochemical genetics
KW  - DNA sequences
KW  - maxadilan
KW  - salivary secretions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Direct interaction of human TFIID with the HIV-1 transactivator Tat.
AU  - Kashanchi, F.
AU  - Piras, G.
AU  - et al.
AU  - Radonovich, M. F. (
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1994///
VL  - 367
SP  - 295
EP  - 299
SN  - 0028-0836
AD  - Kashanchi, F.: Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942005257.  Publication Type: Journal Article.  Language: English. 
KW  - Gene expression
KW  - HIV infections
KW  - Molecular biology
KW  - Regulation
KW  - Transcription
KW  - Transcription factors
KW  - Activation
KW  - DNA transcription
KW  - human immunodeficiency virus infections
KW  - Tat
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005257&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - HIV-1 infection of non-dividing cells.
AU  - Freed, E. O.
AU  - Martin, M. A.
AU  - Emerman, M.\Bukrinsky, M.\Stevenson, M.
T2  - Nature (London)
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1994///
VL  - 369
IS  - May 12
SP  - 107
EP  - 108
SN  - 0028-0836
AD  - Freed, E. O.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19942027001.  Publication Type: Correspondence.  Language: English. 
KW  - cellular biology
KW  - HIV infections
KW  - Infectivity
KW  - Macrophages
KW  - matrix proteins
KW  - Molecular biology
KW  - Pathogenesis
KW  - tropisms
KW  - vpr gene
KW  - cell biology
KW  - Cell infections
KW  - human immunodeficiency virus infections
KW  - Inactivated T lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV.
AU  - Pantaleo, G.
AU  - Demarest, J. F.
AU  - et al.
AU  - Soudeyns, H. (
AU  - Koup, R. A.\Ho, D. D.\Koup, R. A.\Ho, D. D.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1994///
VL  - 370
IS  - Aug. 11
SP  - 463
EP  - 467
SN  - 0028-0836
AD  - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19942006896.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - This paper reports that during the acute clinical syndrome often seen shortly after HIV infection the T-cell-mediated primary immune response is restricted to a set of variable domain Vβ families expressed in CD8+ cytotoxic T lymphocytes. Of great interest is the fact that the most dramatic Vβ expansion occurred in those patients who progressed to AIDS in the shortest time. The patient with the fastest progression time (among the 6 studied) was noted to be HLA-1 B8 which is known to be associated with rapid progression in severe cohort studies. [Further studies along these lines may help elucidate the exact nature and meaning of these interesting documentations. See also R.A. Koup and D.D. Ho (p. 416) for discussion of this work.] A.G. Dalgleish
KW  - acute course
KW  - CD8+ lymphocytes
KW  - Cytotoxic T lymphocytes
KW  - HIV infections
KW  - Immune response
KW  - Immunology
KW  - Seroconversion
KW  - T lymphocytes
KW  - CD8+ cells
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Oligoclonal expansion
KW  - severe course
KW  - T cells
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006896&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum: cDNA and primary protein structure.
AU  - Shahabuddin, M.
AU  - Rawlings, D. J.
AU  - Kaslow, D. C.
JO  - Biochimica et Biophysica Acta, Gene Structure and Expression
JF  - Biochimica et Biophysica Acta, Gene Structure and Expression
Y1  - 1994///
VL  - 1219
IS  - 1
SP  - 191
EP  - 194
SN  - 0167-4781
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, Building 4, Room B1-37, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950802865.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9001-40-5.  Subject Subsets: Protozoology
N2  - The structure of the Plasmodium falciparum-encoded glucose-6-phosphate dehydrogenase (PfG6PD) may provide clues about the relative protection against malaria in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Pfg6pd cDNA encoding a predicted 856 amino acid residues polypeptide with a calculated MW of &gt;94 000 was cloned. The predicted amino acid sequence is highly homologous to G6PD from other organisms. Pfg6pd mapped as a single or low copy number gene to chromosome 14. The unusually large N-terminus and the distance between the NADP-binding site and G6PD-binding site is novel for the parasite G6PD.
KW  - amino acid sequences
KW  - complementary DNA
KW  - genes
KW  - glucose-6-phosphate dehydrogenase
KW  - human diseases
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802865&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Processing of dengue type 4 and other flavivirus nonstructural proteins.
AU  - Lai, C. J.
AU  - Pethel, M.
AU  - Jan, L. R.
AU  - Kawano, H.
AU  - Cahour, A.
AU  - Falgout, B.
A2  - Brinton, M.A.
A2  - Calisher, C.A.
A2  - Rueckert, R.
JO  - Archives of Virology, Supplementum
JF  - Archives of Virology, Supplementum
Y1  - 1994///
IS  - 9
SP  - 359
EP  - 368
CY  - Wien; Austria
PB  - Springer-Verlag
SN  - 0939-1983
SN  - 3211825223\0387825223
AD  - Lai, C. J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940502523.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - Dengue type 4 (DEN4) and other flaviviruses employ host and viral proteases for polyprotein processing. Most proteolytic cleavages in the DEN4 nonstructural protein (NS) region are mediated by the viral NS2B-NS3 protease. The N-terminal third of NS3, containing sequences homologous to serine protease active sites, is the protease domain. To determine required sequences in NS2B, deletions were introduced into DEN4 NS2B-30%NS3 cDNA and the expressed polyproteins assayed for self-cleavage. A 40 amino acid segment within NS2B was essential. Sequence analysis of NS2B predicts that this segment constitutes a hydrophilic domain surrounded by hydrophobic regions. Hydrophobicity profiles of other flavivirus NS2Bs show similar patterns. Cleavage of DEN4 NS1-NS2A requires an octapeptide sequence at the NS1 C terminus and downstream NS2A. Comparison of the analogous octapeptide sequence among flaviviruses indicates a consensus cleavage sequence of (P8)Met/Leu-Val-Xaa-Ser-Xaa-Val-Ala(P1), where Xaa are nonconserved amino acids. The effects on cleavage of amino acid substitutions in this consensus sequence were analysed. Most substitutions of the conserved residues interfered with cleavage, whereas substitutions of non-conserved residues had little or no effect. These findings indicate that the responsible enzyme recognizes well-defined sequences at the cleavage site.
KW  - arboviruses
KW  - cleavage
KW  - processing
KW  - proteins
KW  - viral proteins
KW  - dengue virus
KW  - Flavivirus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - dengue virus type 4
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940502523&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biolistic techniques for transfection of mosquito embryos (Anopheles gambiae).
AU  - Mialhe, E.
AU  - Miller, L. H.
JO  - BioTechniques (Euro Edition)
JF  - BioTechniques (Euro Edition)
Y1  - 1994///
IS  - July/August
SP  - 54
EP  - 61
SN  - 0736-6205
AD  - Mialhe, E.: Laboratory of Malaria Research, Building 4, Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950100409.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 9007-49-2.  Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology
N2  - With a view to increasing the rate of genetic transformation in mosquito embryos, 3 biolistic methods were evaluated: (1) dry biolistics, involving the delivery of dry DNA-coated particles using a commercially available instrument, PDS-1000/He; (2) high pressure biolistics, involving the delivery of an aqueous suspension of DNA-coated particles by PDS-1000/He at 450-650 psi helium pressure; and (3) low pressure biolistics, involving a different accelerator, firstly described for plant transformation, to deliver DNA-coated particles suspended in water. Expression levels of the delivered luciferase gene under the control of the Drosophila heat shock protein 70 promoter were low and highly variable in embryos transfected using the dry method. The level of gene expression increased 100-fold without significantly reducing embryo viability when either of the aqueous methods were used.
KW  - biolistics
KW  - biotechnology
KW  - direct DNA uptake
KW  - DNA
KW  - embryo culture
KW  - embryos
KW  - experimental equipment
KW  - gene expression
KW  - gene transfer
KW  - genetic engineering
KW  - genetic transformation
KW  - instrumentation
KW  - laboratory equipment
KW  - luciferases
KW  - reporter genes
KW  - techniques
KW  - transfection
KW  - viability
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - experimental rigs
KW  - genetic manipulation
KW  - luciferase
KW  - mosquitoes
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Immunology: the role of the parasite.
AU  - Nash, T. E.
A2  - Thompson, R. C. A.
A2  - Reynoldson, J. A.
A2  - Lymbery, A. J.
T2  - Giardia: from molecules to disease.
Y1  - 1994///
CY  - Wallingford; UK
PB  - CAB INTERNATIONAL
SN  - 0851988407
AD  - Nash, T. E.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19940801788.  Publication Type: Book chapter.  Language: English.  Number of References: 61 ref. Subject Subsets: Protozoology
N2  - This chapter covers antigenic variation in Giardia with regard to biological significance and variant-specific surface proteins.
KW  - antigenic variation
KW  - giardiasis
KW  - human diseases
KW  - immunology
KW  - parasites
KW  - Giardia
KW  - Hexamitidae
KW  - protozoa
KW  - Sarcomastigophora
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - giardiosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Regulation of gene expression during squamous differentiation by multiple retinoic acid signalling pathways.
AU  - Jetton, A. M.
AU  - Fujimoto, W.
AU  - Zhang, L. X.
AU  - Marvin, K. W.
AU  - Austin, S.
AU  - Mills, K. J.
AU  - Bernacki, S. H.
AU  - Saunders, N. A.
A2  - Livrea, M. A.
A2  - Vidali, G.
T2  - Retinoids: from basic science to clinical applications.
Y1  - 1994///
CY  - Basel; Switzerland
PB  - Birkhäuser Verlag AG
SN  - 3764328126
AD  - Jetton, A. M.: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19941410255.  Publication Type: Book chapter.  Language: English.  Number of References: 35 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - Evidence that the regulation of squamous differentiation is complex, differs among tissues, and involves a multiplicity of signalling pathways, is reviewed. Vitamin A deficiency induces squamous differentiation in several epithelia including tracheobronchial and uterine epithelia. Retinoids suppress expression in vitro of many squamous cell-specific genes, including involucrin, transglutaminase type 1, cornifin, cholesterol sulfotransferase, loricrin and several keratins. The effect of retinoic acid on the rate of transcription of these genes may be direct or indirect. Retinoids can alter gene expression at either the transcriptional or a post-transcriptional level. By using retinoids that selectively bind and activate RAR or RXR receptors, it was shown that different actions of retinoic acid can be mediated by specific nuclear retinoic acid receptors.
KW  - cell differentiation
KW  - retinoic acid
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cytodifferentiation
KW  - tretinoin
KW  - vitamin A acid
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410255&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Retinoid status, skin tumor formation and differentiation.
AU  - Luca, L. M. de
AU  - Celli, G.
AU  - Kosa, K.
AU  - Ross, S.
AU  - Chen, L. C.
AU  - Jones, C.
AU  - Grover, A.
AU  - Mitchell, S.
AU  - Darwiche, N.
A2  - Livrea, M. A.
A2  - Vidali, G.
T2  - Retinoids: from basic science to clinical applications.
Y1  - 1994///
CY  - Basel; Switzerland
PB  - Birkhäuser Verlag AG
SN  - 3764328126
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19941410263.  Publication Type: Book chapter.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
N2  - The interplay between retinoic acid deficiency and steroid hormones in the development of changes in various epithelia, including transformation of simple columnar epithelium, initially into pseudostratified epithelium, then into squamous stratified, and eventually into the keratinizing squamous stratified phenotype is examined. Results indicated down-regulation of retinoic acid receptor α specifically in skin carcinomas simultaneously with upregulation of retinoid X receptor α (RXRα). The elevated expression of RXRα in carcinomas suggested that certain nuclear signal transduction pathways requiring RXR to form dimers may be elevated because of the growth characteristics and metastatic potential of these cells.
KW  - neoplasms
KW  - nutritional state
KW  - retinoids
KW  - skin
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - dermis
KW  - nutritional status
KW  - vitamin A compounds
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410263&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Regulation of iron metabolism in eukaryotic cells.
AU  - Rouault, T.
AU  - Klausner, R.
A2  - Favier, A. E.
A2  - Neve, J.
A2  - Faure, P.
T2  - Trace elements and free radicals in oxidative diseases.
Y1  - 1994///
CY  - Champaign; USA
PB  - American Oil Chemists' Society
SN  - 0935315535
AD  - Rouault, T.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951404106.  Publication Type: Book chapter.  Language: English.  Number of References: 28 ref. Registry Number: 7439-89-6.  Subject Subsets: Human Nutrition
N2  - This review focusses on the function of 3 proteins that are critical in iron metabolism. These are: ferritin, a 24-subunit iron storage molecule; the transferrin receptor, a membrane receptor that mediates uptake of iron through binding to the serum iron carrier transferrin; and the iron-responsive element binding protein, a cytosolic protein that is involved in sensing iron levels and regulating expression of ferritin, the transferrin receptor, and possibly other genes including the enzyme that is rate-limiting in haem biosynthesis, δ-aminolaevulinate synthase.
KW  - iron
KW  - metabolism
KW  - reviews
KW  - eukaryotes
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404106&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Regulation of epithelial differentiation by retinoids.
AU  - Rosenthal, D.
AU  - Lancillotti, F.
AU  - Darwiche, N.
AU  - Sinha, R.
AU  - Luca, L. M. de
A2  - Blomhoff, R.
T2  - Vitamin A in health and disease.
Y1  - 1994///
CY  - New York; USA
PB  - Marcel Dekker, Inc.
SN  - 0824791207
AD  - Rosenthal, D.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19941407762.  Publication Type: Book chapter.  Language: English.  Number of References: 126 ref. Subject Subsets: Human Nutrition
N2  - Regulation of epithelial differentiation by retinoids is reviewed under the headings: Control of epidermal differentiation by retinoic acid; Retinoid status controls the differentiation of the tracheal epithelium; Retinoids and the vaginal and cervical epithelium.
KW  - differentiation
KW  - epithelium
KW  - regulation
KW  - retinoids
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin A compounds
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407762&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Retinoylation of proteins in mammalian cells.
AU  - Takahashi, N.
AU  - Breitman, T. R.
A2  - Blomhoff, R.
T2  - Vitamin A in health and disease.
Y1  - 1994///
CY  - New York; USA
PB  - Marcel Dekker, Inc.
SN  - 0824791207
AD  - Takahashi, N.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19941407747.  Publication Type: Book chapter.  Language: English.  Number of References: 38 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - Retinoylation of proteins is reviewed under the headings: Retinoylation of nuclear protein in the human acute myeloid leukaemia cell line HL60; Retinoylation in cells with varied sensitivity to retinoic acid; Retinoylation of HL60 protein in the presence of cycloheximide; Labelling of HL60 cellular protein by [³H]palmitic acid (PA) and [³H]myristic acid (MA); Binding of retinoylated protein to DNA-cellulose; Identification of retinoylated proteins; and Retinoylation in fresh cells of patients with myeloid leukaemias.
KW  - antioxidants
KW  - cells
KW  - metabolism
KW  - modification
KW  - proteins
KW  - retinoic acid
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - tretinoin
KW  - vitamin A acid
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407747&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumococcal conjugate vaccines: review and update.
AU  - Klein, D. L.
JO  - Microbial Drug Resistance
JF  - Microbial Drug Resistance
Y1  - 1995///
VL  - 1
IS  - 1
SP  - 49
EP  - 58
AD  - Klein, D. L.: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19952007851.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref. Subject Subsets: Public Health
N2  - A review of the development of conjugate vaccines and their properties.
KW  - conjugate vaccines
KW  - human diseases
KW  - immunization
KW  - reviews
KW  - man
KW  - Streptococcus pneumoniae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Streptococcus
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007851&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro.
AU  - Maciejewski, J. P.
AU  - Weichold, F. F.
AU  - Young, N. S.
AU  - Cara, A.
AU  - Zella, D.
AU  - Reitz, M. S., Jr.
AU  - Gallo, R. C.
AU  - Wainberg, M. A.\Gu, Z. X.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1995///
VL  - 1
IS  - 7
SP  - 667
EP  - 673
AD  - Maciejewski, J. P.: Hematology Branch, National Heart, Lung and Blood Institute, Building 10, Room 7C103, National Institutes of Health, Bethesda, MD 20892-1652, USA.
N1  - Accession Number: 19952006281.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9068-38-6.  Subject Subsets: Public Health
N2  - As current treatments for HIV are unsatisfactory, gene therapy approaches have been adopted including the transfer of genes encoding antibody molecules, a strategy which is termed 'intracellular immunization'. Previous studies targeting gp120 and rev with this approach have shown that the binding of intracellular antibodies to these target proteins can alter the viral life cycle and can be used to inhibit infection. In this current paper the authors have used recombinant techniques to clone genes encoding for the variable regions of the heavy and light chains from murine hybridomas producing anti-reverse transcriptase (RTase) immunoglobulin. The main reason for selecting this target is that it should prevent HIV replication before viral integration into the host genome, therefore allowing the possible resolution of the infected state. In vitro the antibody rendered HIV-permissive cells resistant to infection, with protection being conferred against a wide range of clinical isolates and laboratory strains of both HIV-1 and HIV-2. Strongest inhibitory effects on HIV replication was observed in cell lines transduced with genes encoding for both the H and L chain fragments of anti-RTase, with some degree of HIV inhibition being seen in cultures transduced with H chain fragments only. Future studies are going to focus on the design of a single-chain monoclonal fragment, consisting of fused variable VH and VL chains. The authors concluded that if this could be done efficiently, this approach may be an effective anti-HIV therapy. [In spite of its efficacy against the multiple isolates tried, it remains a distinct possibility that if the treatment has to be given several times to peripheral lymphocytes resistance will inevitably occur.] A. Dalgleish
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - combination therapy
KW  - drug therapy
KW  - gene therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reverse transcriptase
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - chemotherapy
KW  - combined modality therapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - intracellular immunization
KW  - multimodal treatment
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006281&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human retroviruses in the second decade: a personal perspective.
AU  - Gallo, R. C.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1995///
VL  - 1
IS  - 8
SP  - 753
EP  - 759
AD  - Gallo, R. C.: Laboratory of Tumour Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962003166.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
KW  - acquired immune deficiency syndrome
KW  - gene expression
KW  - HIV infections
KW  - HTLV infections
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - molecular biology
KW  - pathogenesis
KW  - replication
KW  - research
KW  - retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003166&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.
AU  - Katayose, D.
AU  - Gudas, J.
AU  - Nguyen, H.
AU  - Srivastava, S.
AU  - Cowan, K. H.
AU  - Seth, P.
JO  - Clinical Cancer Research
JF  - Clinical Cancer Research
Y1  - 1995///
VL  - 1
IS  - 8
SP  - 889
EP  - 897
AD  - Katayose, D.: Medical Breast Cancer Section, Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950404799.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Dairy Science
N2  - A recombinant adenovirus vector (E1 minus) expressing human wild-type p53 cDNA (AdWTp53) was constructed. Infection of normal and tumour cells of lung and mammary epithelial origin with AdWTp53 resulted in high values of wild-type p53 expression. Production of p53 protein following infection was dependent on the dose of AdWTp53. Maximum amounts of p53 were produced following infection with 50 p.f.u./cell. AdWTp53 infection inhibited the growth of all human cell lines studied. However, tumour cells that did not express p53 before infection (H-358 and MDA-MB-157) and tumour cells that expressed mutant endogenous p53 protein (MDA-MB-231 and MDA-MB-453) were more sensitive to AdWTp53 cytotoxicity than cells that contained the wild-type p53 (MCF-7, MCF-10, 184B5 and normal mammary epithelial cells). All cells showed WAF1/Cip1 mRNA and protein induction following AdWTp53 infection. AdWTp53-induced cytotoxicity of human tumour cell lines expressing mutant p53 was mediated by apoptosis as shown by nucleosomal DNA fragmentation analysis. No detectable nucleosomal DNA fragmentation was observed following AdWTp53 infection of human cells expressing wild-type p53. Data suggest that endogenous p53 status is a determinant of AdWTp53-mediated cell killing of human tumour cells.
KW  - cell cultures
KW  - cell lines
KW  - epithelium
KW  - gene expression
KW  - gene therapy
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mammary tumour
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950404799&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line.
AU  - Oravecz, T.
AU  - Roderiquez, G.
AU  - Koffi, J.
AU  - Wang, J.
AU  - Ditto, M.
AU  - Bou-Habib, D. C.
AU  - Lusso, P.
AU  - Norcross, M. A.
AU  - Dalgleish, A. G.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1995///
VL  - 1
IS  - 9
SP  - 919
EP  - 926
AD  - Oravecz, T.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Building 29B, Room 4E12, HFM-541, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009565.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
KW  - cellular biology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - markers
KW  - molecular biology
KW  - pathogenesis
KW  - tropisms
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD26
KW  - cell biology
KW  - cell surfaces
KW  - cell tropism
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - monocytotropic viruses
KW  - viral entry
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009565&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection of human tonsil histocultures: a model for HIV pathogenesis.
AU  - Glushakova, S.
AU  - Baibakov, B.
AU  - Margolis, L. B.
AU  - Zimmerberg, J.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1995///
VL  - 1
IS  - 12
SP  - 1320
EP  - 1322
AD  - Glushakova, S.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002922.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref.
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - laboratory methods
KW  - lymphatic diseases
KW  - pathogenesis
KW  - tissue culture
KW  - tonsils
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - laboratory techniques
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002922&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Laboratory diagnosis of invasive fungal infections in patients with neoplastic diseases.
AU  - Walsh, T. J.
AU  - Lyman, C. A.
AU  - Pizzo, P. A.
A2  - Meunier, F.
T2  - Baillière's Clinical Infectious Diseases
Y1  - 1995///
VL  - 2
IS  - 1
AD  - Walsh, T. J.: Pediatric Branch, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951202886.  Publication Type: Journal Article; Book chapter; Journal article.  Language: English.  Number of References: 219 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The laboratory diagnosis of invasive fungal infections in patients with neoplastic diseases is discussed, including principles of collection, transportation, storage and accession of specimens. Clinical manifestations of invasive Candida infection, direct examination and processing of specimens, detection and significance of fungaemia, histopathology, microbiological identification of Candida spp., differential diagnosis of other yeast isolates, investigational methods of non-culture diagnosis of invasive candidosis (detection of anti-Candida antibodies, detection of Candida antigens by immunoassay), amplification of Candida DNA by the polymerase chain reaction and antifungal susceptibility testing are discussed. Clinical and radiographic correlation in invasive Aspergillus infections, microbiology of aspergillosis, significance of positive Aspergillus spp. cultures and investigational immunodiagnostic, biochemical and molecular methods of diagnosis of invasive aspergillosis are also covered. The diagnosis of other opportunistic infections caused by agents of zygomycosis, Fusarium spp., Pseudallescheria boydii, Trichosporon, Cryptococcus neoformans, Histoplasma capsulatum, Coccidioides immitis and Penicillium spp., is also considered.
KW  - aspergillosis
KW  - candidosis
KW  - cryptococcosis
KW  - diagnosis
KW  - fusariosis
KW  - histoplasmosis
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - pseudallescheriasis
KW  - reviews
KW  - zygomycosis
KW  - Aspergillus
KW  - Candida
KW  - Coccidioides immitis
KW  - Cryptococcus neoformans
KW  - Fusarium
KW  - Histoplasma capsulatum
KW  - man
KW  - Penicillium
KW  - Pseudallescheria boydii
KW  - Trichosporon
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Coccidioides
KW  - Onygenaceae
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Histoplasma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporonaceae
KW  - Ajellomyces capsulatus
KW  - cancers
KW  - candidiasis
KW  - european blastomycosis
KW  - fungus
KW  - fusarioses
KW  - Hyphomycetes
KW  - penicilliosis
KW  - phycomycosis
KW  - trichosporonosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202886&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Highly conserved retroviral zinc fingers as targets for HIV-1 therapeutic management.
AU  - Rice, W. G.
AU  - Turpin, J. A.
AU  - Arthur, L. O.
AU  - Henderson, L. E.
JO  - International Antiviral News
JF  - International Antiviral News
Y1  - 1995///
VL  - 3
IS  - 6
SP  - 87
EP  - 89
SN  - 0965-2310
AD  - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19952006215.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 52-90-4. 
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - chelating agents
KW  - cysteine
KW  - dna binding proteins
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - nucleocapsid proteins
KW  - nucleotide sequences
KW  - residues
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - DNA sequences
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - rational design
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006215&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Discovery and development of disulphide-substituted benzamides as candidate anti-HIV drugs.
AU  - Rice, W. G.
AU  - Arthur, L. O.
AU  - Henderson, L. E.
AU  - Turpin, J. A.
JO  - International Antiviral News
JF  - International Antiviral News
Y1  - 1995///
VL  - 4
IS  - 1
SP  - 03
EP  - 06
SN  - 0965-2310
AD  - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, PO Box B, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19962002654.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref.
KW  - antiviral agents
KW  - dna binding motifs
KW  - HIV infections
KW  - human diseases
KW  - Human immunodeficiency virus 1
KW  - man
KW  - retroviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - benzamides
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002654&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Microsatellite DNA and isozyme variability in a West African population of Anopheles gambiae.
AU  - Lanzaro, G. C.
AU  - Zheng, L.
AU  - Touré, Y. T.
AU  - Traoré, S. F.
AU  - Kafatos, F. C.
AU  - Vernick, K. D.
JO  - Insect Molecular Biology
JF  - Insect Molecular Biology
Y1  - 1995///
VL  - 4
IS  - 2
SP  - 105
EP  - 112
SN  - 0962-1075
AD  - Lanzaro, G. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19950504547.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Microsatellites are defined as tracts of tandemly repeated short DNA sequences. Polymorphisms in this class of DNA are currently being used to generate a genetic map of A. gambiae. The potential of microsatellites as a tool for studying the genetic structure of natural populations of this mosquito were explored. Genetic polymorphism at 20 enzyme coding gene loci and 11 microsatellite DNA loci was surveyed in a population of A. gambiae from Mali. All of the microsatellite loci surveyed were polymorphic, as compared to 40% of the isozyme loci. The mean heterozygosity for the isozyme loci was only 0.097 (±0.0035), but for the microsatellite loci it was 0.732 (±0.060). The pattern of variability was very different between isozymes and microsatellites. Typically, at an isozyme locus a single allele occurred at a frequency ≥0.75, whereas at microsatellite loci the most common allele had a frequency &lt;0.50. It was concluded that microsatellites provide a rich source of genetic polymorphisms for the study of the population genetics of A. gambiae and are in many ways superior to isozymes for this purpose. The potential for utilizing genetically mapped microsatellite loci to explore the effect of chromosomal inversions on the distribution of genetic polymorphisms in A. gambiae are discussed.
KW  - DNA
KW  - enzyme polymorphism
KW  - isoenzymes
KW  - molecular genetics
KW  - population genetics
KW  - Mali
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Francophone Africa
KW  - Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - isozymes
KW  - microsatellite DNA
KW  - mosquitoes
KW  - tandem repeats
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950504547&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lyme disease (borreliosis): a global perspective.
AU  - Burgdorfer, W.
JO  - Alpe Adria Microbiology Journal
JF  - Alpe Adria Microbiology Journal
Y1  - 1995///
VL  - 4
IS  - 4
SP  - 227
EP  - 233
SN  - 1121-9750
AD  - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, 903 South Fourth street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19960503177.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - disease vectors
KW  - human diseases
KW  - Lyme disease
KW  - reviews
KW  - zoonoses
KW  - Borrelia burgdorferi
KW  - Ixodes
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - bacterium
KW  - lyme borreliosis
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503177&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum zinc, and serum lipid profiles in 778 adults.
AU  - Hiller, R.
AU  - Seigel, D.
AU  - Sperduto, R. D.
AU  - Blair, N.
AU  - Burton, T. C.
AU  - Farber, M. D.
AU  - Gragoudas, E. S.
AU  - Gunter, E. W.
AU  - Haller, J.
AU  - Seddon, J. M.
AU  - Sowell, A. L.
AU  - Yannuzzi, L. A.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1995///
VL  - 5
IS  - 6
SP  - 490
EP  - 496
SN  - 1047-2797
AD  - Hiller, R.: Division of Biometry and Epidemiology, National Eye Institute, Bethesda, MD 20892-2510, USA.
N1  - Accession Number: 19961400734.  Publication Type: Journal Article.  Corporate Author: USA, Eye Disease Case-control Study Group Language: English.  Number of References: 47 ref. Registry Number: 7440-66-6.  Subject Subsets: Human Nutrition
N2  - There has been increasing use of high-dosage zinc supplementation in the USA, in particular as a potential treatment for age-related macular degeneration. The relation between fasting serum Zn and serum lipid levels was examined in 778 adults 22 to 80 years old, who were control subjects in a multicentre, clinic-based case-control study. The samples were taken during 1987 to 1990, a time when vitamin/mineral supplementation was becoming increasingly common. Higher serum Zn levels, most notably those above the highest quintile, were associated with higher levels of total serum cholesterol, LDL cholesterol and triglycerides. No significant trend was noted for HDL cholesterol. Previous studies demonstrated that high-dosage Zn supplements raise serum Zn levels. The possibility that use of such supplements can adversely affect serum lipid profiles suggests that chronic ingestion of such supplements should not be done without adequate medical supervision.
KW  - blood
KW  - blood lipids
KW  - lipoproteins
KW  - supplements
KW  - zinc
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400734&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Coadaptation and immunodeficiency virus: lessons from the Felidae.
AU  - Carpenter, M. A.
AU  - O'Brien, S. J.
JO  - Current Opinion in Genetics & Development
JF  - Current Opinion in Genetics & Development
Y1  - 1995///
VL  - 5
IS  - 6
SP  - 739
EP  - 745
SN  - 0959-437X
AD  - Carpenter, M. A.: National Cancer Institute, Frederick, USA.
N1  - Accession Number: 19962211138.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Veterinary Science
N2  - The emergence of pathogenic viruses in new species offers an unusual opportunity to monitor the coadaptation of viruses and their hosts in a dynamic process of intense biological selection. Tracking lentivirus epidemics in man, monkeys and cats reveals genomic struggles at three levels: quasi-species divergence within an individual; coadaptation of virus and host genomes subsequent to disease outbreaks; and transmission, spread and pathogenesis in related host species. Aspects of each level are revealed by examining the genetic diversity of feline immunodeficiency virus in domestic and wild cat species. This approach has been facilitated by the recent genetic characterization of a novel lentivirus in lions.
KW  - acquired immune deficiency syndrome
KW  - evolution
KW  - cats
KW  - feline immunodeficiency virus
KW  - lentivirus
KW  - lions
KW  - man
KW  - Panthera
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Panthera
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - AIDS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pets and Companion Animals (LL070) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962211138&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phylogeny and natural history of the primate lentiviruses, SIV and HIV.
AU  - Hirsch, V. M.
AU  - Dapolito, G.
AU  - Goeken, R.
AU  - Campbell, B. J.
JO  - Current Opinion in Genetics & Development
JF  - Current Opinion in Genetics & Development
Y1  - 1995///
VL  - 5
IS  - 6
SP  - 798
EP  - 806
SN  - 0959-437X
AD  - Hirsch, V. M.: National Institutes of Health, Rockville, MD 20852, USA.
N1  - Accession Number: 19962007016.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref.
KW  - evolution
KW  - genetics
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - phylogeny
KW  - primates
KW  - simian immunodeficiency virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment and experimental therapeutics of blastomycosis.
AU  - St. Georgiev, V.
JO  - International Journal of Antimicrobial Agents
JF  - International Journal of Antimicrobial Agents
Y1  - 1995///
VL  - 6
IS  - 1
SP  - 1
EP  - 12
SN  - 0924-8579
AD  - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951203047.  Publication Type: Journal Article.  Language: English.  Number of References: 182 ref. Registry Number: 1397-89-3, 86386-73-4, 65277-42-1, 22916-47-8.  Subject Subsets: Medical & Veterinary Mycology
N2  - The treatment and experimental therapeutics of blastomycosis are reviewed, including 2-hydroxystilbamidine, amphotericin B, azole derivatives (ketoconazole, fluconazole, miconazole, SCH 39304, ICI 195,739, Bay R 3783 and D0970) and fungal chitin synthase inhibitors (nikkomycins). The role of host defence mechanisms in inhibition of Blastomyces dermatitidis and the treatment of adult respiratory distress syndrome secondary to blastomycosis are also discussed.
KW  - amphotericin B
KW  - antifungal agents
KW  - blastomycosis
KW  - drug therapy
KW  - fluconazole
KW  - human diseases
KW  - infections
KW  - ketoconazole
KW  - miconazole
KW  - reviews
KW  - therapy
KW  - Blastomyces dermatitidis
KW  - man
KW  - Blastomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - 2-hydroxystilbamidine
KW  - Bay R 3783
KW  - chemotherapy
KW  - D0870
KW  - fungistats
KW  - fungus
KW  - ICI 195,739
KW  - SCH 39304
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203047&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease.
AU  - Pavan, W. J.
AU  - Liddell, R. A.
AU  - Wright, A.
AU  - Thibaudeau, G.
AU  - Matteson, P. G.
AU  - McHugh, K. M.
AU  - Siracusa, L. D.
JO  - Mammalian Genome
JF  - Mammalian Genome
Y1  - 1995///
VL  - 6
IS  - 1
SP  - 1
EP  - 7
SN  - 0938-8990
AD  - Pavan, W. J.: Laboratory for Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950102880.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Agricultural Biotechnology
N2  - Mice homozygous for the lethal spotting (ls) mutation exhibit aganglionic megacolon and a white spotted coat owing to a lack of neural crest-derived enteric ganglia and melanocytes. The ls mutation disrupts the migration, differentiation or survival of these neural crest lineages during mammalian development. A human congenital disorder, Hirschsprung disease (HSCR), is also characterized by aganglionic megacolon of the distal bowel and can be accompanied by hypopigmentation of the skin. HSCR has been attributed to multiple loci acting independently or in combination. The ls mouse serves as one animal model for HSCR, and the ls gene may represent 1 of the loci responsible for some cases of HSCR in humans. This study uses 753 N2 progeny from a combination of 3 intersubspecific backcrosses to define the molecular genetic link map of the ls region and to provide resources necessary for positional cloning. Similar to some cases of HSCR, the ls mutation acts semidominantly, its phenotypic effects dependent upon the presence of modifier genes segregating in the crosses. The ls mutation was localized to a 0.8-cM region between the D2Mit113 and D2Mit174 loci. Three genes, endothelin-3 (Edn3), G-protein α-stimulating polypeptide 1 (Gnas), and phosphoenolpyruvate carboxykinase (Pck1) were assessed as candidates for the ls mutation. Only Edn3 and Gnas did not recombine with the ls mutation. It is concluded that mutational analysis of the Edn3 and Gnas genes will determine whether either gene is responsible for the neural crest deficiencies observed in ls/ls mice.
KW  - biotechnology
KW  - colon
KW  - gene mapping
KW  - linkage
KW  - mutations
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Hirschprung disease
KW  - lethal spotting
KW  - neural crest
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950102880&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Review: pain associated with HIV infection.
AU  - Hirschfeld, S.
AU  - Morris, B. K.
JO  - Pediatric AIDS and HIV Infection
JF  - Pediatric AIDS and HIV Infection
Y1  - 1995///
VL  - 6
IS  - 2
SP  - 63
EP  - 74
SN  - 1045-5418
AD  - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962002103.  Publication Type: Journal Article.  Language: English.  Number of References: 176 ref.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pain
KW  - reviews
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002103&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The third wave: HIV infection among heterosexuals in the United States and Europe.
AU  - Haverkos, H. W.
AU  - Quinn, T. C.
JO  - International Journal of STD & AIDS
JF  - International Journal of STD & AIDS
Y1  - 1995///
VL  - 6
IS  - 4
SP  - 227
EP  - 232
SN  - 0956-4624
AD  - Haverkos, H. W.: National Institute on Drug Abuse, Rockville, Maryland, USA.
N1  - Accession Number: 19952007588.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Subject Subsets: Public Health
N2  - An editorial review.
KW  - acquired immune deficiency syndrome
KW  - disease transmission
KW  - epidemiology
KW  - heterosexual transmission
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infections
KW  - injecting drug users
KW  - prevention
KW  - risk factors
KW  - sexual transmission
KW  - surveillance
KW  - Europe
KW  - North America
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - i.v. drug abusers
KW  - i.v. drug users
KW  - intravenous drug users
KW  - United States of America
KW  - venereal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007588&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Brominated chamigrane sesquiterpenes produce a novel profile of differential cytotoxicity in the NCI in vitro screen.
AU  - Rashid, M. A.
AU  - Gustafson, K. R.
AU  - Cardellina, J. H., II
JO  - Natural Product Letters
JF  - Natural Product Letters
Y1  - 1995///
VL  - 6
IS  - 4
SP  - 255
EP  - 259
AD  - Rashid, M. A.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19960310710.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Horticultural Science
N2  - Bioassay-guided fractionation of an extract from the marine alga Laurencia majuscula provided 3 brominated chamigrane sesquiterpenes. These compounds produced a novel pattern of antitumour activity against the National Cancer Institute's in vitro cell line panel. They were cytotoxic to certain cell lines in the colon cancer subpanel at concentrations 10- to 100-fold lower than the mean cytotoxic concentration observed in the other tumour subpanels.
KW  - cell lines
KW  - cytotoxicity
KW  - in vitro
KW  - medicinal plants
KW  - medicinal properties
KW  - neoplasms
KW  - organobromine compounds
KW  - plant composition
KW  - screening
KW  - sesquiterpenes
KW  - algae
KW  - Ceramiales
KW  - Rhodomelaceae
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - eukaryotes
KW  - Rhodophyta
KW  - algae
KW  - seaweeds
KW  - Ceramiales
KW  - cancers
KW  - chemical constituents of plants
KW  - drug plants
KW  - Laurencia
KW  - Laurencia majuscula
KW  - medicinal herbs
KW  - officinal plants
KW  - screening tests
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960310710&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine regulation of granuloma formation in schistosomiasis.
AU  - Wynn, T. A.
AU  - Cheever, A. W.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1995///
VL  - 7
IS  - 4
SP  - 505
EP  - 511
SN  - 0952-7915
AD  - Wynn, T. A.: National Institutes of Health, Building 4/126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800793.  Publication Type: Journal Article.  Language: English.  Number of References: 61 ref. Registry Number: 308079-78-9.  Subject Subsets: Helminthology
N2  - This review focuses primarily on recent advances concerning the role of Th1 and Th2 cytokines in granuloma formation in schistosomiasis under the headings: Th2 cytokines induce granulomatous inflammation; Th1-associated cytokines suppress granuloma formation; adhesion molecules, chemokines and TNF-α; cytokines and downmodulation.
KW  - cytokines
KW  - granuloma
KW  - helminths
KW  - immunopathology
KW  - inflammation
KW  - parasites
KW  - reviews
KW  - t lymphocytes
KW  - tumour necrosis factor
KW  - Schistosoma mansoni
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - downregulation
KW  - granulomas
KW  - immunopathogenesis
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - T helper cells
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800793&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fluconazole versus itraconazole in therapy of oropharyngeal candidiasis in cancer patients: a prospective comparative randomized trial.
AU  - Studená, V.
AU  - Sycová, Z.
AU  - Helpianska, L.
AU  - Sorkovská, D.
AU  - Pichna, P.
AU  - Lacka, J.
AU  - Hlavacova, E.
AU  - Oravcová, E.
AU  - Krčméry, V., Jr.
AU  - Studená, M.
AU  - Kukucková, E.
JO  - Journal of Chemotherapy
JF  - Journal of Chemotherapy
Y1  - 1995///
VL  - 7
IS  - Suppl. 4
SP  - 204
EP  - 205
SN  - 1120-009X
AD  - Studená, V.: National Cancer Institute, 83301 Bratislava, Slovakia.
N1  - Accession Number: 19961201898.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 4 ref. Registry Number: 86386-73-4, 84625-61-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - A prospective, randomized trial was conducted to compare the efficacy and toxicity of fluconazole (100 mg/d for 10 d) and itraconazole (100 mg/d for 15 d) in the treatment of 53 cancer patients from Bratislava, Slovakia, with oropharyngeal candidosis. Infections were due to Candida albicans (39 cases), C. tropicalis (3), Torulopsis glabrata (3), and C. krusei and C. albicans (8). Fluconazole showed a better efficacy and mycological eradication rate (94.7%) than itraconazole (86%; P&lt;0.01). The relapse rate in the itraconazole group was 53.8% compared with 21% in the fluconazole-treated group.
KW  - antifungal agents
KW  - candidosis
KW  - clinical trials
KW  - drug therapy
KW  - efficacy
KW  - fluconazole
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - itraconazole
KW  - mouth
KW  - neoplasms
KW  - opportunistic infections
KW  - pharynx
KW  - predisposition
KW  - therapy
KW  - Slovakia
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida tropicalis
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Torulopsis
KW  - Pezizomycotina
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Advances in antimicrobial chemotherapy
KW  - cancers
KW  - Candida krusei
KW  - candidiasis
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nucleic acid vaccines.
AU  - Vogel, F. R.
AU  - Sarver, N.
JO  - Clinical Microbiology Reviews
JF  - Clinical Microbiology Reviews
Y1  - 1995///
VL  - 8
IS  - 3
SP  - 406
EP  - 410
SN  - 0893-8512
AD  - Vogel, F. R.: Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010038.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Public Health
N2  - The author reviews the development of nucleic acid vaccines.
KW  - immunization
KW  - nucleic acids
KW  - reviews
KW  - vaccine development
KW  - vaccines
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010038&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Schistosomiasis.
AU  - James, S.
AU  - Colley, D.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1995///
VL  - 8
IS  - 5
SP  - 351
EP  - 355
SN  - 0951-7375
AD  - James, S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960801271.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Schistosomiasis is reviewed with reference to epidemiology and clinical disease, diagnosis, chemotherapy, vaccine development, experimental pathogenesis and human immunology. Research on biochemical and immunological resistance mechanisms to infection, disease development and drug action should contribute to the design of more efficacious integrated control strategies.
KW  - clinical aspects
KW  - control
KW  - diagnosis
KW  - drug therapy
KW  - epidemiology
KW  - helminths
KW  - human diseases
KW  - immunology
KW  - parasites
KW  - pathogenesis
KW  - resistance
KW  - reviews
KW  - schistosomiasis
KW  - vaccines
KW  - man
KW  - Schistosoma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - chemotherapy
KW  - clinical picture
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801271&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Does zidovudine cause non-Hodgkin's lymphoma?
AU  - Coté, T. R.
AU  - Biggar, R. J.
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1995///
VL  - 9
IS  - 4
SP  - 404
EP  - 405
SN  - 0269-9370
AD  - Coté, T. R.: The AIDS/Cancer Study Group, Viral Epidemiology Branch, National Cancer Institute, EPN-434, 6130 Executive Blvd, Rockville, MD 20852, USA.
N1  - Accession Number: 19952006585.  Publication Type: Correspondence.  Language: English.  Number of References: 6 ref. Registry Number: 30516-87-1. 
KW  - acquired immune deficiency syndrome
KW  - aetiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - non-Hodgkin's lymphoma
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - AZT
KW  - causal agents
KW  - etiology
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006585&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-10 synergizes with multiple cytokines in enhancing HIV production in cells of monocytic lineage.
AU  - Weissman, D.
AU  - Poli, G.
AU  - Fauci, A. S.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1995///
VL  - 9
IS  - 5
SP  - 442
EP  - 449
AD  - Weissman, D.: Laboratory of Immunoregulation, National Institutes of Health, Building 10, Room 6A02, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010478.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref.
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - interleukins
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010478&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relation between stage of disease and neurobehavioral measures in children with symptomatic HIV disease.
AU  - Brouwers, P.
AU  - Tudor-Williams, G.
AU  - DeCarli, C.
AU  - Moss, H. A.
AU  - Wolters, P. L.
AU  - Civitello, L. A.
AU  - Pizzo, P. A.
JO  - AIDS
JF  - AIDS
Y1  - 1995///
VL  - 9
IS  - 7
SP  - 713
EP  - 720
SN  - 0269-9370
AD  - Brouwers, P.: Pediatric Branch, National Cancer Institute, NIH Clinical Center, Rm 13N240, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19952007548.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref.
KW  - acquired immune deficiency syndrome
KW  - CD4 antigens
KW  - central nervous system
KW  - clinical aspects
KW  - core protein p24
KW  - diseases
KW  - encephalopathy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - markers
KW  - neurology
KW  - paediatrics
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD4
KW  - clinical picture
KW  - CNS
KW  - cognitive dyfunction
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - p24
KW  - p24 antigen
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007548&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neutralization of primary HIV-1 isolates by anti-envelope monoclonal antibodies.
AU  - D'Souza, M. P.
AU  - Milman, G.
AU  - Bradac, J. A.
AU  - McPhee, D.
AU  - Hanson, C. V.
AU  - Hendry, R. M.
JO  - AIDS
JF  - AIDS
Y1  - 1995///
VL  - 9
IS  - 8
SP  - 867
EP  - 874
SN  - 0269-9370
AD  - D'Souza, M. P.: Pathogenesis and Basis Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Solar Building, Room 2C35, Bethesda MD 20892, USA.
N1  - Accession Number: 19952009247.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
KW  - envelope proteins
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - laboratory methods
KW  - monoclonal antibodies
KW  - neutralization
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - laboratory techniques
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009247&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV infection and AIDS risk behaviors among injecting drug users entering methadone treatment: an update.
AU  - Battjes, R. J.
AU  - Pickens, R. W.
AU  - Brown, L. S. Jr
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1995///
VL  - 10
IS  - 1
SP  - 90
EP  - 96
AD  - Battjes, R. J.: National Institute on Drug Abuse, 5600 Fishers Lane, Room 10A-38, Rockville, MD 20857, USA.
N1  - Accession Number: 19962001102.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 1095-90-5, 76-99-3. 
KW  - acquired immune deficiency syndrome
KW  - behaviour
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - injecting drug users
KW  - methadone
KW  - prevention
KW  - risk behaviour
KW  - sexual behaviour
KW  - sociology
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - behavior
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - i.v. drug abusers
KW  - i.v. drug users
KW  - intravenous drug users
KW  - risk behavior
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - social aspects
KW  - treatment centers
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001102&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relation between human T-lymphotropic virus type I and neurologic diseases in Panama: 1985-1990.
AU  - Gracia, F.
AU  - Castillo, L. C.
AU  - Larreategui, M.
AU  - Roberts, B.
AU  - Cedeño, V.
AU  - Heneine, W.
AU  - Blattner, W.
AU  - Kaplan, J. E.
AU  - Levine, P. H.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1995///
VL  - 10
IS  - 2
SP  - 192
EP  - 197
AD  - Gracia, F.: Correspondence address: P.H. Levine, Viral Epidemiology Branch, Executive Plaza North 434, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001117.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Tropical Diseases
N2  - Human T-cell lymphotropic virus type I (HTLV-I) is endemic in the Caribbean basin and in Japan. HTLV-II, a closely related virus, is endemic in several groups of native Americans, including Panamanian Guaymi. In Panama, a nationwide HTLV-I/II seroprevalence of 102% has been reported. The authors evaluated the frequency of HTLV-I/II infection in patients with neurological diseases admitted to state tertiary hospitals in Panama City between 1985 and 1990. Nineteen of 322 patients with eligible diagnoses had antibodies to HTLV-I/II, 17 with HTLV-I and 2 with HTLV-II. HTLV-I was associated with spastic paraparesis (13 of 23, 56.5% vs. 4 of 299, 1.3%, P &lt;0.001) and with cerebellar syndrome (2 of 13, 15.4%) and multiple sclerosis (2 of 54, 3.7%) (P &lt;0.05 for both diseases compared with subject with none of these diagnoses). The two HTLV-I infected patients with cerebellar syndrome later developed spastic paraparesis. HTLV-II infection was noted in one patient with cerebellar syndrome and one with amyotrophic lateral sclerosis. All patients with other diagnoses were seronegative. Among patients with spastic paraparesis, HTLV-I-infected patients were clinically indistinguishable from seronegative subjects. There is apparently an overlapping clinical spectrum of neurologic diseases associated with HTLV-I and HTLV-II infection.
KW  - brain
KW  - epidemiology
KW  - HTLV-I infections
KW  - human diseases
KW  - infections
KW  - nervous system
KW  - nervous system diseases
KW  - neurology
KW  - sclerosis
KW  - tropical spastic paraparesis
KW  - Central America
KW  - Panama
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human t-cell lymphotropic virus type ii
KW  - man
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - Central America
KW  - Developing Countries
KW  - Latin America
KW  - Threshold Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - cerebrum
KW  - HTLV-BLV group
KW  - neuropathy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001117&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence specificity in the higher-order interaction of the Rev protein of HIV-1 with its target sequence, the RRE.
AU  - Powell, D. M.
AU  - Zhang, M. J.
AU  - Konings, D. A. M.
AU  - Wingfield, P. T.
AU  - Stahl, S. J.
AU  - Dayton, E. T.
AU  - Dayton, A. J.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1995///
VL  - 10
IS  - 3
SP  - 317
EP  - 323
AD  - Powell, D. M.: Correspondence address: A.I. Dayton, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001123.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
KW  - binding
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - mutations
KW  - Rev protein
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Rev response elements
KW  - wild type
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001123&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: the phenanthroline-cuprous complex.
AU  - Mazumder, A.
AU  - Gupta, M.
AU  - Perrin, D. M.
AU  - Sigman, D. S.
AU  - Rabinovitz, M.
AU  - Pommier, Y.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 1
SP  - 115
EP  - 125
SN  - 0889-2229
AD  - Mazumder, A.: Laboratory of Molecular Pharmacology, Bldg. 37, Rm. 5C25, Division of Cancer Treatment, Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952005041.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
KW  - antiviral agents
KW  - human diseases
KW  - inhibition
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - phenanthroline-cuprous complex
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005041&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chitinase as a vaccine.
AU  - Shahabuddin, M.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1995///
VL  - 11
IS  - 2
SP  - 46
EP  - 47
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805918.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 9001-06-3.  Subject Subsets: Helminthology; Protozoology
N2  - The suggestion that chitinase could be a potential generalized target for blocking the transmission of various parasites is discussed with reference to recent studies on Brugia malayi and Wuchereria bancrofti. The presence of chitinase in Plasmodium, Leishmania and Trypanosoma is also discussed.
KW  - chitinase
KW  - helminths
KW  - human diseases
KW  - parasites
KW  - vaccines
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805918&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Humoral and cellular immune responses in rhesus macaques infected with human immunodeficiency virus type 2.
AU  - Abimiku, A. G.
AU  - Franchini, G.
AU  - Aldrich, K.
AU  - Myagkikh, M.
AU  - Markham, P.
AU  - Gard, E.
AU  - Gallo, R. C.
AU  - Robert-Guroff, M.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 3
SP  - 383
EP  - 393
SN  - 0889-2229
AD  - Abimiku, A. G.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007424.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref.
KW  - animal models
KW  - cytotoxic T lymphocytes
KW  - HIV-2 infections
KW  - human diseases
KW  - immune response
KW  - Human immunodeficiency virus 2
KW  - Macaca
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - human immunodeficiency virus type 2
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007424&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The cytoplasmic ribosomal RNAs of Plasmodium spp.
AU  - McCutchan, T. F.
AU  - Li, J.
AU  - McConkey, G. A.
AU  - Rogers, M. J.
AU  - Waters, A. P.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1995///
VL  - 11
IS  - 4
SP  - 134
EP  - 138
AD  - McCutchan, T. F.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19950807486.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Protozoology
N2  - Understanding of Plasmodium spp. cytoplasmic ribosomal RNA genes whose expression is developmentally regulated is reviewed under the headings: genomic organization of rDNA units; individual genes, rRNAs and transcriptional control; ramifications of rRNA analysis.
KW  - development
KW  - gene expression
KW  - genes
KW  - molecular genetics
KW  - parasites
KW  - ribosomal RNA
KW  - Plasmodium
KW  - protozoa
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Herbal pharmacotherapy for the attenuation of electroconvulsive shock-induced anterograde and retrograde amnestic deficits.
AU  - Faruqi, S.
AU  - Chittaranjan Andrade
AU  - Ramteke, S.
AU  - Joseph, J.
AU  - Venkataraman, B. V.
AU  - Naga Rani, M. A.
JO  - Convulsive Therapy
JF  - Convulsive Therapy
Y1  - 1995///
VL  - 11
IS  - 4
SP  - 241
EP  - 247
AD  - Faruqi, S.: Department of Pharmacology, St. John's Medical College, National Institute of Mental Health and Neurosciences, Bangalore, India.
N1  - Accession Number: 19960309810.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Horticultural Science
N2  - BR-16A is an herbal medication used in India to enhance cognition. Sixty adult male Sprague Dawley rats received either BR-16A (200 mg/kg) or vehicle alone for 16 days. During the first 7 days, rats were trained in a spatial memory task using the Hebb Williams complex maze. Once a day for the next 2 days, rats received either true or sham electroconvulsive shock (ECS) treatments. During the last 7 days of the study, rats were reexposed to the maze to assess recall of pre-ECS training and to evaluate further improvement in learning scores. BR-16A-treated rats performed better than controls both before and after ECS. It is concluded that BR-16A facilitates learning and that this effect extends to a protection against ECS-induced anterograde and retrograde amnesia. BR-16A may hence hold promise in the restriction of ECT-induced cognitive compromise. An unexpected observation in this study was that BR-16A attenuated seizure duration; implications and mechanisms are discussed.
KW  - anticonvulsant properties
KW  - herbal drugs
KW  - learning
KW  - medicinal plants
KW  - nervous system
KW  - pharmacology
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anti-convulsant properties
KW  - anti-epileptic properties
KW  - BR-16A
KW  - drug plants
KW  - herbal medicines
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Science (General) (FF000) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Syncytium formation in cultured human lymphoid tissue: fusion of implanted HIV glycoprotein 120/41-expressing cells with native CD4+ cells.
AU  - Margolis, L. B.
AU  - Glushakova, S.
AU  - Baibakov, B.
AU  - Zimmerberg, J.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 6
SP  - 697
EP  - 704
SN  - 0889-2229
AD  - Margolis, L. B.: Correspondence address: J. Zimmerberg, Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Building 10, Room 10014, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008195.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
KW  - cellular biology
KW  - formation
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pathogenesis
KW  - syncytia
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cell biology
KW  - fusion
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008195&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antisense phosphorothioate oligodeoxynucleotides alter HIV type 1 replication in cultured human macrophages and peripheral blood mononuclear cells.
AU  - Weichold, F. F.
AU  - Lisziewicz, J.
AU  - Zeman, R. A.
AU  - Nerurkar, L. S.
AU  - Agrawal, S.
AU  - Reitz, M. S. Jr.
AU  - Gallo, R. C.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 7
SP  - 863
EP  - 867
SN  - 0889-2229
AD  - Weichold, F. F.: Hematology Branch, Building 10, Room 7C103, NHLBI, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-1652, USA.
N1  - Accession Number: 19952010935.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
KW  - antiviral agents
KW  - cell culture
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - macrophages
KW  - replication
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - oligodeoxynucleotides
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010935&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Highly attentuated HIV type 2 recombinant poxviruses, but not HIV-2 recombinant Salmonella vaccines, induce long-lasting protection in rhesus macaques.
AU  - Franchini, G.
AU  - Robert-Guroff, M.
AU  - Tartaglia, J.
AU  - Aggarwal, A.
AU  - Abimiku, A.
AU  - Benson, J.
AU  - Markham, P.
AU  - Limbach, K.
AU  - Hurteau, G.
AU  - Fullen, J.
AU  - Aldrich, K.
AU  - Miller, N.
AU  - Sadoff, J.
AU  - Paoletti, E.
AU  - Gallo, R. C.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 8
SP  - 909
EP  - 920
SN  - 0889-2229
AD  - Franchini, G.: Laboratory of Tumor Cell Biology, Building 37, Room 6A11, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952010434.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - immunization
KW  - immunology
KW  - recombinant vaccines
KW  - vectors
KW  - Human immunodeficiency virus 2
KW  - Macaca
KW  - man
KW  - poxviridae
KW  - Salmonella typhimurium
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - AIDS
KW  - bacterium
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 2
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010434&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain.
AU  - Ott, D. E.
AU  - Coren, L. V.
AU  - Johnson, D. G.
AU  - Sowder, R. C. II
AU  - Arthur, L. O.
AU  - Henderson, L. E.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 9
SP  - 1003
EP  - 1006
SN  - 0889-2229
AD  - Ott, D. E.: AIDS Vaccine Program, Program Resources Incorporated/Dyn Corp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19952011091.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infectivity
KW  - pathogenesis
KW  - proteins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cyclophilin A
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - virions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952011091&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Conference on Advances in AIDS Vaccine Development: Seventh Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS, November 6-10, 1994.
AU  - Lawrence, D. N.
AU  - Schultz, A. M.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 10
SP  - 1277
EP  - 1319
SN  - 0889-2229
AD  - Lawrence, D. N.: Vaccine and Prevention Research Program, Division of AIDS, NIAID, National Institutes of Health, Solar Building, Room 2A28A, 6003 Executive Boulevard, Rockville, MD 20892-7620, USA.
N1  - Accession Number: 19962001150.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - BCG vaccine
KW  - cytotoxic T lymphocytes
KW  - design
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - peptides
KW  - vaccines
KW  - viral diseases
KW  - Listeria monocytogenes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Listeria
KW  - Listeriaceae
KW  - Bacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - AIDS
KW  - bacterium
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001150&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HLA Class II on HIV particles is functional in superantigen presentation to human T cells: implications for HIV pathogenesis.
AU  - Rossio, J. L.
AU  - Bess, J. Jr
AU  - Henderson, L. E.
AU  - Cresswell, P.
AU  - Arthur, L. O.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1995///
VL  - 11
IS  - 12
SP  - 1433
EP  - 1439
SN  - 0889-2229
AD  - Rossio, J. L.: AIDS Vaccine Program, Program Resources, Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19962002019.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref.
KW  - antigens
KW  - cell mediated immunity
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - major histocompatibility complex
KW  - pathogenesis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenicity
KW  - cellular immunity
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - superantigens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current approaches to the development of vaccines against disease caused by respiratory syncytial virus (RSV) and parainfluenza virus (PIV).
AU  - Crowe, J. E., Jr.
JO  - Vaccine
JF  - Vaccine
Y1  - 1995///
VL  - 13
IS  - 4
SP  - 415
EP  - 421
SN  - 0264-410X
AD  - Crowe, J. E., Jr.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962000817.  Publication Type: Journal Article; Conference paper; Journal article.  Corporate Author: WHO Programme for Vaccine Development. Language: English. 
N2  - A report of a meeting held in Nyon, Switzerland on 27 March 1994 by the WHO Programme for Vaccine Development.
KW  - human diseases
KW  - immunization
KW  - parainfluenza
KW  - parainfluenza viruses
KW  - vaccine development
KW  - vaccines
KW  - human respiratory syncytial virus
KW  - man
KW  - Pneumovirus
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Pneumovirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Paramyxovirinae
KW  - immune sensitization
KW  - parainfluenza virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunoreactive antigenic sites of Cysticercus cellulosae relevant to human neurocysticercosis - immunocytochemical localization using human CSF as source of antibody.
AU  - Shankar, S. K.
AU  - Ravi, V.
AU  - Suryanarayana, V.
AU  - Chandramukhi, A.
AU  - Ravikumar, B. V.
JO  - Clinical Neuropathology
JF  - Clinical Neuropathology
Y1  - 1995///
VL  - 14
IS  - 1
SP  - 33
EP  - 36
SN  - 0722-5091
AD  - Shankar, S. K.: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India.
N1  - Accession Number: 19960800475.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Helminthology
N2  - In order to identify the relevant antigens of Cysticercus cellulosae [Taenia solium] recognized within the human central nervous system, immunocytochemical localization of antigens on the larva was carried out using cerebrospinal fluid of patients as the source of primary antibody. CSF from 9 proven cases of neurocysticercosis, 2 cases of culture-proven tuberculous meningitis, and 2 cases of spinal disc prolapse with no other infective or neurological disorders, were used in this study. The CSF from all the cases of neurocysticercosis reacted intensely with the glycocalyx over the integument of the cyst bladder wall. The other structures recognised by the CSF antibodies were the cytoplasm of the tegumentary cytons, stroma and the ductular system of the bladder wall. The cells, stroma and calcareous corpuscles of the scolex reacted to varying degrees with the CSF. The tegument of the spiral canal and sucker muscles in the scolex were not immunoreactive. These results suggest that the glycocalyx is the most antigenic anatomical structure of the C. cellulosae and that patients develop antibodies to it.
KW  - antibodies
KW  - antigens
KW  - developmental stages
KW  - helminths
KW  - human diseases
KW  - immunocytochemistry
KW  - metacestodes
KW  - neurocysticercosis
KW  - parasites
KW  - Taenia solium
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - growth phase
KW  - immunogens
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Successful treatment of catheter-associated fungemia due to Candida krusei and Trichosporon beigelii in a leukemic patient receiving prophylactic itraconazole.
AU  - Špánik, S.
AU  - Kollár, T.
AU  - Gyarfáš, J.
AU  - Kunová, A.
AU  - Krčméry, V.
JO  - European Journal of Clinical Microbiology & Infectious Diseases
JF  - European Journal of Clinical Microbiology & Infectious Diseases
Y1  - 1995///
VL  - 14
IS  - 2
SP  - 148
EP  - 149
SN  - 0934-9723
AD  - Špánik, S.: Department of Clinical Medicine, National Cancer Institute and University of Trnava, 833 03 Bratislava, Slovakia.
N1  - Accession Number: 19951202400.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Registry Number: 1397-89-3, 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case of catheter-associated fungaemia due to C. krusei and T. beigelii is reported in a 19-yr-old man from Slovakia with acute myelogenous leukaemia. The patient was receiving prophylactic itraconazole. Intravenous amphotericin B (50 mg/kg daily) was administered and the central venous catheter was removed. Because the patient refused further hospitalization, he was discharged on oral fluconazole (400 mg/d) for 14 d. Chest X-ray, ophthalmological examination and ultrasound examination 35 d after resolution of the fungaemia failed to reveal any late consequences such as organ involvement.
KW  - amphotericin B
KW  - antifungal agents
KW  - blood
KW  - candidosis
KW  - case reports
KW  - catheters
KW  - drug therapy
KW  - fluconazole
KW  - fungaemia
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - leukaemia
KW  - opportunistic infections
KW  - predisposition
KW  - therapy
KW  - Slovakia
KW  - Candida acidothermophilum
KW  - man
KW  - Trichosporon beigelii
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - blood cancer
KW  - Candida krusei
KW  - candidiasis
KW  - chemotherapy
KW  - fungemia
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - leucaemia
KW  - leukemia
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202400&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Successful treatment of catheter-related fusarial infection in immunocompromised children.
AU  - Velasco, E.
AU  - Martins, C. A.
AU  - Nucci, M.
JO  - European Journal of Clinical Microbiology & Infectious Diseases
JF  - European Journal of Clinical Microbiology & Infectious Diseases
Y1  - 1995///
VL  - 14
IS  - 8
SP  - 697
EP  - 699
SN  - 0934-9723
AD  - Velasco, E.: Infectious Disease Department, Hospital do Cancer, National Cancer Institute, Rio de Janeiro, RJ, Brazil.
N1  - Accession Number: 19951202924.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - Cases are reported in 4 children (aged 3-12 yr) from Brazil with acute leukaemia or solid tumours, who developed catheter-related fusarial infection. Blood cultures drawn through the central venous catheter grew Fusarium spp. in all cases. All patients recovered after removal of the central venous catheter and treatment with amphotericin B.
KW  - amphotericin B
KW  - antifungal agents
KW  - blood
KW  - case reports
KW  - catheters
KW  - children
KW  - drug therapy
KW  - fungaemia
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - leukaemia
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - therapy
KW  - Brazil
KW  - Fusarium
KW  - man
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - blood cancer
KW  - cancers
KW  - chemotherapy
KW  - fungemia
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - leucaemia
KW  - leukemia
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202924&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Report of catheter-associated Trichosporon pullulans break-through fungemia in a cancer patient.
AU  - Kunová, A.
AU  - Sorkovská, D.
AU  - Sufliarsky, J.
AU  - Helpianska, L.
AU  - Krčméry, V.
T2  - European Journal of Clinical Microbiology & Infectious Diseases
JO  - European Journal of Clinical Microbiology & Infectious Diseases
JF  - European Journal of Clinical Microbiology & Infectious Diseases
Y1  - 1995///
VL  - 14
IS  - 8
SP  - 729
EP  - 730
SN  - 0934-9723
AD  - Kunová, A.: Department of Medicine, National Cancer Institute, Medical School and University of Trnava, 833 10 Bratislava, Slovakia.
N1  - Accession Number: 19951202926.  Publication Type: Correspondence.  Language: English.  Number of References: 3 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 65-yr-old woman from Slovakia with ovarian cancer who developed fever after chemotherapy despite receiving prophylactic ketoconazole. Blood cultures grew T. pullulans, which was also cultured from the tip of a central venous catheter. The catheter was removed and intravenous amphotericin B was administered (0.5 mg/kg daily) but the patient's condition deteriorated and she died.
KW  - blood
KW  - case reports
KW  - catheters
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - mycoses
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - Slovakia
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - cancers
KW  - fungus
KW  - Hyphomycetes
KW  - Trichosporon pullulans
KW  - trichosporonosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202926&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Developmentally regulated expression of a Giardia lamblia cyst wall protein gene.
AU  - Mowatt, M. R.
AU  - Luján, H. D.
AU  - Cotten, D. B.
AU  - Bowers, B.
AU  - Yee, J.
AU  - Nash, T. E.
AU  - Stibbs, H. H.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995///
VL  - 15
IS  - 5
SP  - 955
EP  - 963
SN  - 0950-382X
AD  - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960802780.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Subject Subsets: Protozoology
N2  - The expression of a gene of Giardia lamblia [Giardia duodenalis] that encodes a protein component of the cyst wall was investigated. Transcripts from the cyst wall protein gene increased more than 100-fold during encystation, reaching a maximum between 5 and 24 h after induction. Cyst wall protein expression also increased dramatically during encystation, and, prior to its incorporation into the nascent cyst wall, the protein is contained within the encystation-specific vesicles of encysting trophozoites. The sequence of the cloned gene predicts an acidic, leucine-rich polypeptide of MW 26 000 that contains 5.3 tandemly arranged copies of a degenerate 24-amino-acid repeat. A hydrophobic amino-terminal peptide probably serves as the initial signal that targets this protein to a secretory pathway involving vesicular localization during encystation and, ultimately, secretion to form the cyst wall.
KW  - amino acid sequences
KW  - developmental stages
KW  - gene expression
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - transcription
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - cyst wall protein
KW  - DNA sequences
KW  - DNA transcription
KW  - growth phase
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802780&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The human immunodeficiency virus type 1 Rev protein and the Rev-responsive element counteract the effect of an inhibitory 5′ splice site in a 3′ untranslated region.
AU  - Barksdale, S. K.
AU  - Baker, C. C.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1995///
VL  - 15
IS  - 6
SP  - 2962
EP  - 2971
SN  - 0270-7306
AD  - Barksdale, S. K.: Laboratory of Tumor Virus Viology, National Cancer Institute, Bethesda, MD 20892-5055, USA.
N1  - Accession Number: 19962002081.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref.
KW  - gene expression
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - Rev protein
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Rev responsive element
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002081&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum protein, lipid and selected vitamins during caloric restriction and soyabean supplementation in the diet of normal and tumour bearing mice.
AU  - Purna Mukhopadhyay
AU  - Jamuna Bhattacharyya
AU  - Utpal Sanyal
AU  - Sukta Das
JO  - Nutrition Research
JF  - Nutrition Research
Y1  - 1995///
VL  - 15
IS  - 7
SP  - 983
EP  - 992
SN  - 0271-5317
AD  - Purna Mukhopadhyay: Department of Experimental Leukaemia, Chittaranjan National Cancer Institute, Calcutta - 700 026, India.
N1  - Accession Number: 19951413642.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 68-26-8, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - The effects of a soyabean diet during 40% energy restriction on serum protein, lipids and vitamin status of the host were evaluated in Moloney virus-induced leukaemia (MVL) and Dalton's ascitic lymphoma (DL) bearing mice and compared with normal controls. The levels of serum vitamins A and E which declined in the presence of tumours could be improved following soyabean supplementation. Increased serum albumin noted during energy restriction could be brought down to the normal level using the soya diet. Significant hypercholesterolaemic effects of the soyabean diet were noted in all cases. The study indicates that alterations of protein, lipid and vitamins in the serum of a tumour bearing host could be modified by specific diets along with better control of the disease.
KW  - blood
KW  - blood lipids
KW  - blood proteins
KW  - energy deprivation
KW  - neoplasms
KW  - retinol
KW  - soyabeans
KW  - supplements
KW  - vitamin E
KW  - vitamins
KW  - Glycine (Fabaceae)
KW  - mice
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - axerophthol
KW  - blood plasma proteins
KW  - blood serum proteins
KW  - cancers
KW  - soybeans
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413642&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Association of postprandial triglyceride and retinyl palmitate responses with asymptomatic carotid artery atherosclerosis in middle-aged men and women. The Atherosclerosis Risk in Communities (ARIC) Study.
AU  - Sharrett, A. R.
AU  - Chambless, L. E.
AU  - Heiss, G.
AU  - Paton, C. C.
AU  - Patsch, W.
JO  - Arteriosclerosis, Thrombosis, and Vascular Biology
JF  - Arteriosclerosis, Thrombosis, and Vascular Biology
Y1  - 1995///
VL  - 15
IS  - 12
SP  - 2122
EP  - 2129
AD  - Sharrett, A. R.: Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockledge Bldg Room 8164, Bethesda, MD 20892-7934, USA.
N1  - Accession Number: 19961406911.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 79-81-2.  Subject Subsets: Human Nutrition
N2  - Blood lipid alterations after a fatty meal may be atherogenic, but there is little information regarding their associations with disease independent of fasting lipids. Asymptomatic atherosclerosis cases (n=229) and 373 control subjects free of atherosclerosis, as defined by carotid intima-media thickness on ultrasound images, were given a fatty meal with vitamin A, followed by 3.5- and 8-h measurements of triglycerides (TGs), TG-rich lipoprotein TGs, apoprotein B48 and retinyl palmitate. Among white men and women but not among blacks, case status was associated with greater postprandial responses of TGs and TG-rich lipoprotein TGs, but only in nonobese persons (body mass index &lt;30 kg/m²). The associations were strong and significant after controlling for coronary risk factors (odds ratio, ~2.0) and fasting TGs (odds ratio, 1.5). Associations with other postprandial lipid measurements did not persist after controlling for fasting lipids. Elevated postprandial TGs appear to be an independent risk factor for carotid intimal thickening in nonobese whites. The lack of such a relation in obese subjects and the lipid profile they manifest suggest that postprandial TGs must be accompanied by accumulation of TG-rich lipoprotein remnants to be atherogenic.
KW  - atherosclerosis
KW  - blood lipids
KW  - fats
KW  - intake
KW  - lipoproteins
KW  - retinyl palmitate
KW  - triacylglycerols
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - retinol palmitate
KW  - triglycerides
KW  - vitamin A palmitate
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406911&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human herpesvirus 6 in AIDS.
AU  - Lusso, P.
AU  - Gallo, R. C.
JO  - Immunology Today
JF  - Immunology Today
Y1  - 1995///
VL  - 16
IS  - 2
SP  - 67
EP  - 71
SN  - 0167-4919
AD  - Lusso, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MA 20892, USA.
N1  - Accession Number: 19962002096.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
KW  - acquired immune deficiency syndrome
KW  - aetiology
KW  - CD4+ lymphocytes
KW  - disease course
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune system
KW  - natural killer cells
KW  - herpesviridae
KW  - human herpesvirus 6
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - causal agents
KW  - CD4+ cells
KW  - disease progression
KW  - etiology
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002096&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nonspecific and lymphocytic interstitial pneumonitis in HIV-infected individuals.
AU  - Ognibene, F. P.
JO  - Seminars in Respiratory and Critical Care Medicine
JF  - Seminars in Respiratory and Critical Care Medicine
Y1  - 1995///
VL  - 16
IS  - 3
SP  - 227
EP  - 230
AD  - Ognibene, F. P.: National Institutes of Health, Critical Care Medicine Department, Building 10, Room 7D43, 10 Center Drive, MSC-1662, Bethesda, MD 20892-1662, USA.
N1  - Accession Number: 19962006939.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lungs
KW  - pathology
KW  - pneumonitis
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - general account
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - lymphocytic interstitial pneumonitis
KW  - non-specific interstitial pneumonitis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anti-interleukin-4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine schistosomiasis japonica.
AU  - Cheever, A. W.
AU  - Finkelman, F. D.
AU  - Cox, T. M.
JO  - Parasite Immunology
JF  - Parasite Immunology
Y1  - 1995///
VL  - 17
IS  - 2
SP  - 103
EP  - 109
SN  - 0141-9838
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803940.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Anti-interleukin-4 (IL-4) treatment of Schistosoma japonicum infected mice markedly inhibited in vitro secretion of the Th2 cytokines IL-4 and IL-5 from antigen stimulated spleen cells, but enhanced the secretion of the Th1 cytokine IFN-γ. IL-2 secretion was unaffected. Hepatic fibrosis was markedly diminished in anti IL-4 treated mice at 10 weeks pi while granulomas around S. japonicum eggs in the liver were slightly-to-moderately increased in size. The number of eggs/worm pair in the tissues and faeces did not differ significantly in treated and untreated mice. It is suggested that Th2 cytokine responses are important in the genesis of schistosomal hepatic fibrosis.
KW  - cytokines
KW  - experimental infections
KW  - fibrosis
KW  - helminths
KW  - hepatic fibrosis
KW  - human diseases
KW  - interferon
KW  - interleukin 4
KW  - interleukin 5
KW  - laboratory animals
KW  - liver
KW  - parasites
KW  - pathogenesis
KW  - schistosomiasis
KW  - Digenea
KW  - mice
KW  - Muridae
KW  - rodents
KW  - Schistosoma japonicum
KW  - Schistosomatidae
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - bilharzia
KW  - bilharziasis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803940&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunoregulation in human lymphatic filariasis: the role of interleukin 10.
AU  - Siddhartha Mahanty
AU  - Nutman, T. B.
JO  - Parasite Immunology
JF  - Parasite Immunology
Y1  - 1995///
VL  - 17
IS  - 8
SP  - 385
EP  - 392
SN  - 0141-9838
AD  - Siddhartha Mahanty: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19950809063.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 130068-27-8.  Subject Subsets: Helminthology; Tropical Diseases
N2  - In humans with lymphatic filariasis, microfilaraemia is associated with a parasite antigen-specific hyporesponsiveness when assessed by cell proliferation and secretion of interleukin-2 and interferon-γ. Hyporesponsiveness in these individuals is not only parasite antigen-specific but appears to be limited to Th1-type responses. Th2-mediated responses such as IL-5 secretion and IgE antibody production to parasite antigens are generally strong and usually no different than those seen in immunologically more reactive amicrofilaraemic individuals with chronic lymphatic pathology. The mechanisms by which Th1 responses are inhibited have not yet been elucidated, but some studies suggest that down-regulatory cytokines such as IL-10 may be involved in this process. Mononuclear cells from microfilaraemic individuals have been found to secrete greater quantities of IL-10 spontaneously and in response to parasite antigens. Mechanisms by which IL-10 may be induced by the parasite and the mode by which IL-10 may regulate parasite antigen-specific Th1 responses in these individuals are discussed.
KW  - cytokines
KW  - helminths
KW  - infections
KW  - interleukin 10
KW  - interleukins
KW  - lymphatic filariasis
KW  - parasites
KW  - T lymphocytes
KW  - man
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - immunomodulation
KW  - immunoregulation
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - T helper cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809063&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Determination of the anti-HIV drug 2′-β-fluoro-2′,3′-dideoxyadenosine in biological fluids by reversed-phase HPLC.
AU  - Roth, J. S.
AU  - Kelley, J. A.
JO  - Journal of Liquid Chromatography
JF  - Journal of Liquid Chromatography
Y1  - 1995///
VL  - 18
IS  - 3
SP  - 441
EP  - 462
SN  - 0148-3919
AD  - Roth, J. S.: Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Building 37, Room 5C-02, Bethesda, MD 20892-0037, USA.
N1  - Accession Number: 19952010173.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
KW  - analogues
KW  - antiviral agents
KW  - biological fluids
KW  - detection
KW  - dideoxynucleosides
KW  - drugs
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - medicines
KW  - pharmaceuticals
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010173&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Racial difference in body core temperature between Pima Indian and Caucasian men.
AU  - Rising, R.
AU  - Fontvieille, A. M.
AU  - Larson, D. E.
AU  - Spraul, M.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1995///
VL  - 19
IS  - 1
SP  - 1
EP  - 5
SN  - 0307-0565
AD  - Rising, R.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541-A, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19951404520.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Human Nutrition
N2  - A low body temperature is associated with a low metabolic rate for a given body size and body composition. It was tested whether Pima Indians have lower body temperatures than Caucasians, a trait which might partly explain the high prevalence of obesity in this population. 25 Pima Indian (28±6 years old, 87.8±22.8 kg, 29±9% body fat) and 25 Caucasian (30±5 years old, 80.7±18.4 kg, 22±11% body fat) men had body core temperatures measured by telemetry for 24 h while in a respiratory chamber. Mean daily body core temperature was 36.93±0.12 and 36.90±0.22°C in Pima Indians and Caucasians, respectively. Since body core temperatures during sleep (SLBCT) correlated with percentage body fat, a subset of 10 Pima Indians and 10 Caucasians were pair-matched for body weight and percentage body fat. In this group, SLBCT was lower in Pima Indians than in Caucasians (36.45±0.10 vs. 36.65±0.27°C; P&lt;0.01) and, ethnic group accounted for 20% of the variance in SLBCT (P&lt;0.01). Surprisingly, the lower SLBCT was not associated with a low metabolic rate and therefore does not seem to play a role in the aetiology of obesity in Pima Indians.
KW  - body composition
KW  - body temperature
KW  - ethnic groups
KW  - metabolism
KW  - obesity
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Social Structure (UU480) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404520&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food intake and energy expenditure in obese female bingers and non-bingers.
AU  - Alger, S.
AU  - Seagle, H.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1995///
VL  - 19
IS  - 1
SP  - 11
EP  - 16
SN  - 0307-0565
AD  - Alger, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes, National Institutes of Health, 4212 North 16th Street, Room 541-A, Arizona 85016, USA.
N1  - Accession Number: 19951404522.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
N2  - Daily energy intake, dietary composition and energy expenditure were compared among obese binge eaters and obese non-bingers. 9 obese bingers (33±4 years old, 95±6 kg body weight, 39±1% body fat) and 9 obese non-bingers (47±3 years old, 93±5 kg body weight, 40±1% body fat) were admitted for 12 days to a metabolic unit. Binge eaters were defined as scoring &gt;25 on the binge eating scale (BES). During the initial 8 days, subjects ate freely from 2 computerized vending machines offering a variety of foods and beverages. A weight maintenance diet was then provided for the next 4 days. 24 h energy expenditure (24EE) and respiratory quotient (24Q) were measured on the last day of both feeding periods in a respiratory chamber. Obese bingers showed a wider range of energy intake compared to non-bingers, but the mean daily energy intake was similar between the 2 groups (2587±454 vs. 2386±201 kcal/day) during 8 days of free intake. 24EE was not different between bingers and non-binger after 8 days of free intake (2298±147 vs. 2109±97 kcal/day, P=0.3) or 4 days of weight maintenance diet, even more so after adjustment for differences in fat-free mass, fat mass and age. Resting metabolic rate, sleeping metabolic rate, and macronutrient intake and oxidation were also similar between groups. In a controlled experimental environment, obese binge eaters exhibited a greater variability in daily energy intake than non-bingers, but showed no difference in mean daily energy intake, diet composition or metabolic rate compared to obese non-bingers.
KW  - appetite disorders
KW  - behaviour
KW  - body composition
KW  - energy exchange
KW  - energy intake
KW  - feeding behaviour
KW  - food intake
KW  - obesity
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - behavior
KW  - eating disorders
KW  - fatness
KW  - feeding behavior
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404522&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spontaneous overfeeding with a "cafeteria diet" in men: effects on 24-hour energy expenditure and substrate oxidation.
AU  - Larson, D. E.
AU  - Rising, R.
AU  - Ferraro, R. T.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1995///
VL  - 19
IS  - 5
SP  - 331
EP  - 337
SN  - 0307-0565
AD  - Larson, D. E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N Sixteenth Street, Room 541, Phoenix, Arizona, 85016, USA.
N1  - Accession Number: 19951407085.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Human Nutrition
N2  - To investigate the relationship between obesity and ad libitum food intake (quantity and composition) and to assess the impact of ad libitum food intake on energy expenditure and macronutrient oxidation, male non-diabetic Pima Indian covering a wide range of body weight and body composition (30±8 years, 102.1±30.2 kg, 34± 9% body fat) were first fed a weight maintaining diet for at least 4 days before selecting their food for the next 5 days from 2 computerized vending machines offering a variety of familiar, palatable foods. 24-h energy expenditure (24EE) and substrate oxidation were measured in a respiratory chamber in the last day of each weight maintenance and ad libitum intake periods. Weight maintenance requirements averaged 2913±342 kcal/day. Energy intake during the ad libitum period increased to 4550±921 kcal/day (12±1% protein, 40±4% fat, 48±4% carbohydrate) i.e., a spontaneous overeating by 54±32% above the weight maintenance requirement, resulting in a 0.9±1.0 kg body weight gain. Neither the composition of the selected diet nor the degree of overeating was associated with physical characteristics, such as body weight and body consumption. When compared with baseline, spontaneous overeating on day 5 was associated with a 396±233 kcal/day increase in 24EE, a 607±503 kcal/day increase in carbohydrate oxidation, a 214±392 kcal/day decrease in lipid oxidation (P&lt;0.01), and no change in protein oxidation. Increased carbohydrate oxidation correlated with the excess carbohydrate intake (r = 0.69, P=0.0001) accounting for 68±13% of the excess, whereas excess fat intake was not oxidized. In response to spontaneous overfeeding on a mixed "cafeteria diet", excess carbohydrate intake is oxidized, suggesting a physiological control of carbohydrate stores, whereas excess fat intake is channeled toward fat stores. None of the observed changes were related to indices of obesity.
KW  - effects
KW  - energy
KW  - energy exchange
KW  - food intake
KW  - men
KW  - nutrition physiology
KW  - obesity
KW  - overfeeding
KW  - oxidation
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - overnutrition
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407085&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relations of body fat and fat distribution to the serum lipid, apolipoprotein and insulin concentrations of Samoan men and women.
AU  - Galanis, D. J.
AU  - McGarvey, S. T.
AU  - Sobal, J.
AU  - Bausserman, L.
AU  - Levinson, P. D.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1995///
VL  - 19
IS  - 10
SP  - 731
EP  - 738
SN  - 0307-0565
AD  - Galanis, D. J.: Epidemiology, Demography and Biometry Program, National Institute of Aging, 7201 Wisconsin Ave., Gateway Bldg., Suite 3C-309, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951413228.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - 178 men and 147 women who were free from hypertension, diabetes and heart disease were investigated. In multivariate linear regression analyses in men body mass index (BMI) was positively associated with levels of total cholesterol, the total-HDL cholesterol ratio, apolipoprotein B and the log of triglyceride and insulin concentrations, and negatively associated with HDL and HDL2 cholesterol. The quadratic term for BMI was also found to be significantly predictive of all metabolic parameters in men, except for the log of serum insulin concentrations. Among women, in contrast, BMI levels were significantly associated only with concentrations of HDL2 cholesterol, triglyceride and insulin. In men, the associations between the abdomen-hip circumference ratio (AHR) and metabolic parameters were similar to those described for BMI, but showed no indication of non-linearity. Addition of the log of insulin to these models had little effect on the relations between the AHR and the lipid parameters, with the exceptions of total cholesterol and triglycerides. As with BMI, AHR was much less predictive of metabolic parameters in women than in men, with a significant relation existing only with the log of insulin concentrations.
KW  - apolipoproteins
KW  - blood
KW  - blood lipids
KW  - body composition
KW  - body fat
KW  - distribution
KW  - insulin
KW  - men
KW  - sex differences
KW  - women
KW  - American Samoa
KW  - Samoa
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Oceania
KW  - Oceania
KW  - Least Developed Countries
KW  - Developing Countries
KW  - Polynesia
KW  - Pacific Islands
KW  - ACP Countries
KW  - Commonwealth of Nations
KW  - Western Samoa
KW  - Human Nutrition (General) (VV100) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variability in metabolic rate: biological sites of regulation.
AU  - Tataranni, P. A.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1995///
VL  - 19
IS  - sup 4
SP  - S102
EP  - S106
SN  - 0307-0565
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N. 16th Street, Rm 541, Phoenix, Arizonia 85016, USA.
N1  - Accession Number: 19951413690.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Human Nutrition
N2  - Evidence on the variability of resting metabolic rate is discussed and new lines of research into this topic are suggested.
KW  - metabolism
KW  - regulation
KW  - resting energy exchange
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Suppurative cutaneous granulomata caused by Microascus cinereus in a patient with chronic granulomatous disease.
AU  - Marques, A. R.
AU  - Kwon-Chung, K. J.
AU  - Holland, S. M.
AU  - Turner, M. L.
AU  - Gallin, J. I.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1995///
VL  - 20
IS  - 1
SP  - 110
EP  - 114
SN  - 1058-4838
AD  - Marques, A. R.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseses, National Institutes of Health, Bethesda, MD 20892-1886, USA.
N1  - Accession Number: 19961200400.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 9-yr-old girl from Maryland, USA, with chronic granulomatous disease who presented with erythematous papular skin lesions on the chest, back and arm. Examination of biopsy specimens from the lesions on the arm and back showed suppurative granulomata in association with acute and chronic inflammation. Histopathological examination of a specimen from the lesion on the arm revealed fungal elements and cultures yielded M. cinereus. The patient was treated with 2.5 g of intravenous amphotericin B during a 10 wk period and the lesions resolved.
KW  - case reports
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - Maryland
KW  - USA
KW  - man
KW  - Microascaceae
KW  - Microascus
KW  - Pezizomycotina
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Microascales
KW  - Sordariomycetes
KW  - Microascaceae
KW  - Microascus
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Ascomycotina
KW  - chronic granulomatous disease
KW  - fungus
KW  - Microascus cinereus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200400&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The balance of interests in natural products development. The National Cancer Institute's letter of collection.
AU  - Mays, T. D.
AU  - Duffy Mazan, K.
JO  - Interciencia
JF  - Interciencia
Y1  - 1995///
VL  - 20
IS  - 3
SP  - 130
EP  - 133
SN  - 0378-1844
AD  - Mays, T. D.: National Cancer Institute, NIH, Building 3, Room 4A51, 900 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970300471.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Horticultural Science
N2  - The natural products programme of the National Cancer Institute (NCI) is described. The NCI letter of collection (LOC) agreement is a contractual agreement that permits the recognition of and promotes the sharing of financial rewards with indigenous peoples and source countries for their contribution to the identification and collection of natural products with potential therapeutic value in the treatment of cancer and AIDS [acquired immune deficiency syndrome]. LOC provisions, NCI obligations and source country obligations are briefly presented.
KW  - acquired immune deficiency syndrome
KW  - antineoplastic properties
KW  - antiviral properties
KW  - indigenous knowledge
KW  - medicinal properties
KW  - natural products
KW  - neoplasms
KW  - plant composition
KW  - AIDS
KW  - anti-neoplastic properties
KW  - anti-viral properties
KW  - cancers
KW  - chemical constituents of plants
KW  - Plant Science (General) (FF000) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Laws and Regulations (DD500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Management of chronic viral hepatitis in children.
AU  - Conjeevaram, H. S.
AU  - Bisceglie, A. M. di
JO  - Journal of Pediatric Gastroenterology and Nutrition
JF  - Journal of Pediatric Gastroenterology and Nutrition
Y1  - 1995///
VL  - 20
IS  - 4
SP  - 365
EP  - 375
SN  - 0277-2116
AD  - Conjeevaram, H. S.: Liver Diseases Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952004568.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - With reference to hepatitis B, C, and D infections in children, the authors discuss the epidemiology and natural history of infections, serodiagnosis, immunotherapy and prevention stategies.
KW  - children
KW  - diagnosis
KW  - epidemiology
KW  - hepatitis B
KW  - hepatitis C
KW  - hepatitis D
KW  - human diseases
KW  - immunotherapy
KW  - management
KW  - reviews
KW  - viral hepatitis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fungemia in children infected with the human immunodeficiency virus: new epidemiologic patterns, emerging pathogens, and improved outcome with antifungal therapy.
AU  - Walsh, T. J.
AU  - Gonzalez, C.
AU  - Roilides, E.
AU  - Mueller, B. U.
AU  - Ali, N.
AU  - Lewis, L. L.
AU  - Whitcomb, T. O.
AU  - Marshall, D. J.
AU  - Pizzo, P. A.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1995///
VL  - 20
IS  - 4
SP  - 900
EP  - 906
SN  - 1058-4838
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Building 10, Room 13N-240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005653.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - A total of 27 episodes of fungaemia in 22 children at the Pediatric Branch of the National Cancer Institute, Bethesda, USA, who were infected with HIV were characterized. Fungaemia in these patients presented as a community-acquired infection in the setting of out-patient total parenteral nutrition or intravenous antibiotic therapy through a chronically indwelling central venous catheter (CVC). Fungaemia developed only in patients with CVCs (P&lt;0.001). Non-albicansCandida spp. (C. parapsilosis, C. tropicalis, C. krusei), Torulopsis glabrata, Rhodotorula rubra and Bipolaris spicifera [Cochliobolus spicifer] constituted 52% of all causes; C. albicans was the aetiological agent in the remainder. Fungaemia was detected early, within a median of 24 d after the onset of new fever, which permitted prompt administration of amphotericin B (mean dosage, 0.7 mg/kg daily; median duration, 19 d). CVCs were removed in 23 (85%) of the episodes. It is concluded that fungaemia in HIV-infected children often presents as a community-acquired infection, is frequently due to newly emerging opportunistic fungi and can be managed, with a high level of success (95% survival with no post-therapeutic sequelae), by early diagnosis, prompt initiation of amphotericin B therapy and removal of the CVC.
KW  - acquired immune deficiency syndrome
KW  - amphotericin B
KW  - antifungal agents
KW  - blood
KW  - catheters
KW  - children
KW  - drug therapy
KW  - epidemiology
KW  - fungaemia
KW  - HIV infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - Maryland
KW  - USA
KW  - Candida
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - cochliobolus spicifer
KW  - man
KW  - Pleosporaceae
KW  - Rhodotorula mucilaginosa
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Cochliobolus
KW  - Pleosporaceae
KW  - Pleosporales
KW  - Dothideomycetes
KW  - Pezizomycotina
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Rhodotorula
KW  - Sporidiobolales
KW  - Microbotryomycetes
KW  - Pucciniomycotina
KW  - Basidiomycota
KW  - Torulopsis
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - Candida krusei
KW  - chemotherapy
KW  - fungemia
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - Rhodotorula rubra
KW  - Torulopsis glabrata
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytomegalovirus ureteritis as a cause of renal failure in a child infected with the human immunodeficiency virus.
AU  - Mueller, B. U.
AU  - MacKay, K.
AU  - Cheshire, L. B.
AU  - Choyke, P. L.
AU  - Kitchen, B.
AU  - Widemann, B.
AU  - Pizzo, P. A.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1995///
VL  - 20
IS  - 4
SP  - 1040
EP  - 1051
SN  - 1058-4838
AD  - Mueller, B. U.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005656.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
KW  - diagnosis
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inflammation
KW  - opportunistic infections
KW  - paediatrics
KW  - renal failure
KW  - ureter
KW  - cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - kidney failure
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005656&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiretroviral therapy: reference guide to major clinical trials in patients infected with human immunodeficiency virus.
AU  - Spooner, K. M.
AU  - Lane, H. C.
AU  - Masur, H.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1995///
VL  - 20
IS  - 5
SP  - 1145
EP  - 1151
SN  - 1058-4838
AD  - Spooner, K. M.: Correspondence address: H. Masur, National Institutes of Health, 10 Center Drive, MSC 1662, Building 10, Room 7D43, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007852.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref.
KW  - antiviral agents
KW  - clinical trials
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007852&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biological correlates of binge eating.
AU  - Yanovski, S. Z.
JO  - Addictive Behaviors
JF  - Addictive Behaviors
Y1  - 1995///
VL  - 20
IS  - 6
SP  - 705
EP  - 712
SN  - 0306-4603
AD  - Yanovski, S. Z.: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-6600, USA.
N1  - Accession Number: 19961405298.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Human Nutrition
N2  - Neuroendocrine and metabolic abnormalities are seen in both anorexia nervosa and bulimia nervosa, but they have not been described in binge eating disorder, in which neither starvation nor compensatory behaviours are present. Although findings may reflect biologic differences among subgroups of binge eaters, an alternative explanation is that many of the biological correlates of binge eating are the result of metabolic derangement secondary to starvation and/or purging. The identification of binge eating disorder provides an opportunity to study the causes and concomitants of binge eating in the absence of compensatory behaviours.
KW  - appetite disorders
KW  - metabolism
KW  - nutrition physiology
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - eating disorders
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961405298&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Foetal nutrition and the risk of non-insulin-dependent diabetes mellitus in Pima Indians.
AU  - Nelson, R. G.
AU  - McCance, D. R.
AU  - Pettitt, D. J.
JO  - Proceedings of the Nutrition Society of New Zealand
JF  - Proceedings of the Nutrition Society of New Zealand
Y1  - 1995///
VL  - 20
SP  - 89
EP  - 95
SN  - 0110-4187
AD  - Nelson, R. G.: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
N1  - Accession Number: 19961407058.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 14 ref. Subject Subsets: Human Nutrition
N2  - A U-shaped relationship between diabetes prevalence and birth weight has been described in the Pima Indians with the highest diabetes prevalence in those with the lowest and highest birth weight. The increased risk of diabetes among those with a high birth weight can be explained largely by the presence of maternal diabetes during pregnancy. The increased risk among those with a low birth weight may be due to impaired development of the foetal pancreas associated with nutritional deprivation or to the selective survival of low birth-weight infants that are genetically susceptible to the development of diabetes.
KW  - birth weight
KW  - diabetes
KW  - ethnic groups
KW  - fetal development
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407058&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Proteins binding to the promoter region of the operon encoding the major outer surface proteins OspA and OspB of Borrelia burgdorferi.
AU  - Margolis, N.
AU  - Samuels, D. S.
JO  - Molecular Biology Reports
JF  - Molecular Biology Reports
Y1  - 1995///
VL  - 21
IS  - 3
SP  - 159
EP  - 164
SN  - 0301-4851
AD  - Margolis, N.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19960504263.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - The synthesis of the major outer surface proteins OspA and OspB in B. burgdorferi varies among strains and during in vitro cultivation. B. burgdorferi CA-11.2A was examined for the presence of proteins that bind to the ospAB operon promoter region. 3 major DNA-protein complexes were detected using a mobility shift assay; one of these complexes was due to sequence-specific binding. These proteins may be involved in the regulation of ospAB transcription and the pathogenesis of Lyme disease.
KW  - binding proteins
KW  - DNA
KW  - human diseases
KW  - Lyme disease
KW  - molecular genetics
KW  - operons
KW  - proteins
KW  - transcription
KW  - Borrelia burgdorferi
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - carrier proteins
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - lyme borreliosis
KW  - outer surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960504263&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sinusitis in children infected with human immunodeficiency virus: clinical characteristics, risk factors, and prophylaxis.
AU  - Mofenson, L. M.
AU  - Korelitz, J.
AU  - Pelton, S.
AU  - Moye, J. Jr.
AU  - Nugent, R.
AU  - Bethel, J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1995///
VL  - 21
IS  - 5
SP  - 1175
EP  - 1181
SN  - 1058-4838
AD  - Mofenson, L. M.: Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Executive Building, Room 4B11, 6100 Executive Boulevard MSC 7510, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19962000501.  Publication Type: Journal Article.  Corporate Author: USA, National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group. Language: English.  Number of References: 30 ref.
KW  - children
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - opportunistic infections
KW  - sinusitis
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000501&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Severe Burkholderia (Pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases.
AU  - Ross, J. P.
AU  - Holland, S. M.
AU  - Gill, V. J.
AU  - DeCarlo, E. S.
AU  - Gallin, J. I.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1995///
VL  - 21
IS  - 5
SP  - 1291
EP  - 1293
SN  - 1058-4838
AD  - Ross, J. P.: Laboratories of Host Defenses and Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19962004452.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Public Health
N2  - A report of 2 cases in men aged 22 and 34 years in the USA.
KW  - bacterial diseases
KW  - case reports
KW  - epidemiology
KW  - human diseases
KW  - infections
KW  - North America
KW  - USA
KW  - Burkholderia gladioli
KW  - man
KW  - Burkholderia
KW  - Burkholderiaceae
KW  - Burkholderiales
KW  - Betaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - Pseudomonas gladioli
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004452&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food choices of whites, blacks, and Hispanics: data from the 1987 National Health Interview Survey.
AU  - Patterson, B. H.
AU  - Harlan, L. C.
AU  - Block, G.
AU  - Kahle, L.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1995///
VL  - 23
IS  - 2
SP  - 105
EP  - 119
SN  - 0163-5581
AD  - Patterson, B. H.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7354, USA.
N1  - Accession Number: 20001413039.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - An overview of the diets of whites, blacks and Hispanics is presented using data from the 1987 National Health Interview Survey (NHIS). Food frequency data from the 1987 NHIS on 20 143 adults were used to estimate the percentage of adults, by gender and race/ethnicity, who consume some 59 foods six or more times per year, median number of servings for consumers, and frequency of consumption of skin on poultry and fat on red meat. On the basis of percent consumption of these foods, women appear to have a more diverse diet than men. Women eat more fruits and vegetables, less meat, and fewer high-fat foods and drink fewer alcoholic beverages. Whites eat a more varied diet than blacks and Hispanics; blacks eat more fried and high-fat food; consumption of high-fat foods is lowest among Hispanics. Public health messages, especially those aimed at cancer prevention, should be targeted at increasing the overall consumption of fruits and vegetables, decreasing consumption of high-fat foods, especially among white and black men, and increasing consumption of those healthful foods already consumed by particular race/ethnicity groups.
KW  - alcoholic beverages
KW  - beverages
KW  - blacks
KW  - Caucasian
KW  - consumers
KW  - diet studies
KW  - ethnic groups
KW  - food consumption
KW  - foods
KW  - fruits
KW  - guidelines
KW  - health
KW  - Hispanics
KW  - mortality
KW  - neoplasms
KW  - poultry
KW  - prevention
KW  - public health
KW  - reviews
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - death rate
KW  - domesticated birds
KW  - drinks
KW  - recommendations
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413039&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type-1 integrase.
AU  - Mazumder, A.
AU  - Pommier, Y.
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1995///
VL  - 23
IS  - 15
SP  - 2865
EP  - 2871
SN  - 0305-1048
AD  - Mazumder, A.: Correspondence address: Y. Pommier, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 37, Room 5C25, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001501.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 951-78-0. 
KW  - acquired immune deficiency syndrome
KW  - catalytic activity
KW  - deoxyuridine
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nucleotides
KW  - substrates
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - integrase
KW  - reverse transciptase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001501&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - AIDS and cancer registry linkage: measurement and enhancement of registry completeness.
AU  - Coté, T. R.
AU  - O'Brien, T. R.
AU  - Ward, J. W.
AU  - Wilson, S. E.
AU  - Blattner, W. A.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1995///
VL  - 24
IS  - 4
SP  - 375
EP  - 377
SN  - 0091-7435
AD  - Coté, T. R.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, EPN-434, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19952009862.  Publication Type: Journal Article.  Corporate Author: USA, National AIDS/Cancer Match Study Group Language: English.  Number of References: 9 refs.
KW  - acquired immune deficiency syndrome
KW  - epidemiology
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - registration
KW  - statistics
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cancers
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009862&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).
AU  - Kozak, C. A.
AU  - Gatignol, A.
AU  - Graham, K.
AU  - Jeang, K. T.
AU  - McBride, O. W.
JO  - Genomics (San Diego)
JF  - Genomics (San Diego)
Y1  - 1995///
VL  - 25
IS  - 1
SP  - 66
EP  - 72
SN  - 0888-7543
AD  - Kozak, C. A.: Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950102735.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Agricultural Biotechnology
N2  - Infection with the HIV-1 virus requires the involvement of host cell factors. The identification of these and the elucidation of their specific functions has been difficult. A human cDNA, TRBP, was previously cloned and characterized as a positive regulator of gene expression that binds to the TAR region of the HIV-1 genome. In this study this factor was shown to be encoded by a gene, TARBP2, that maps to human chromosome 12 and mouse chromosome 15, and 1 human pseudogene (TARBP2P) and 2 mouse TRBP-related sequences (Tarbp2-rs1, Tarbp2-rs2) were identified and mapped. The map location of the expressed gene identifies it as a candidate for the previously identified factor encoded on human chromosome 12 that has been shown to be important for expression of HIV-1 genes. Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells.
KW  - biotechnology
KW  - diseases
KW  - DNA binding proteins
KW  - gene mapping
KW  - genetic mapping
KW  - human immunodeficiency viruses
KW  - protein
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950102735&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3.
AU  - Patel, A.
AU  - Rochelle, J. M.
AU  - Jones, J. M.
AU  - Sumegi, J.
AU  - Uhl, G. R.
AU  - Seldin, M. F.
AU  - Meisler, M. H.
AU  - Gregor, P.
JO  - Genomics (San Diego)
JF  - Genomics (San Diego)
Y1  - 1995///
VL  - 25
IS  - 1
SP  - 314
EP  - 317
SN  - 0888-7543
AD  - Patel, A.: Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Box 5180, Baltimore, MD 21224, USA.
N1  - Accession Number: 19950102857.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 107-35-7.  Subject Subsets: Agricultural Biotechnology
N2  - The gene encoding the taurine transporter, Taut, was mapped to the central region of mouse chromosome 6. By analysing a cross that segregated the neurological mutant mnd2, Taut was excluded as a candidate gene for this closely linked mutation. To map the human taurine transporter gene, TAUT, a sequence-tagged site (STS) corresponding to the 3′ untranslated region of the human cDNA was developed. TAUT was assigned to human chromosome 3 by typing this STS on a panel of somatic cell hybrids. Further analysis of a hybrid panel containing defined deletions of chromosome 3 suggested that TAUT maps to 3p21-p25. These data extend a conserved linkage group on mouse chromosome 6 and human chromosome 3p. Deletion of TAUT might contribute to some phenotypic features of the 3p- syndrome.
KW  - biotechnology
KW  - gene mapping
KW  - mapping
KW  - neurotransmitters
KW  - taurine
KW  - transporters
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cartography
KW  - implement trailers
KW  - implement transporters
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950102857&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro anti-HIV-1 activity of HIV protease inhibitor KNI-272 in resting and activated cells: implications for its combined use with AZT or ddI.
AU  - Chokekijchai, S.
AU  - Shirasaka, T.
AU  - Weinstein, J. N.
AU  - Mitsuya, H.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1995///
VL  - 28
IS  - 1
SP  - 25
EP  - 38
SN  - 0166-3542
AD  - Chokekijchai, S.: Correspondence address: H. Mitsuya, Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009153.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref.
KW  - acquired immune deficiency syndrome
KW  - analogues
KW  - antiviral agents
KW  - combination therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nucleoside analogues
KW  - nucleosides
KW  - proteinase inhibitors
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - analogs
KW  - combined modality therapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - multimodal treatment
KW  - nucleoside analogs
KW  - protease inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009153&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2′,3′-dideoxy-3′-thiacytidine.
AU  - Kavlick, M.
AU  - Shirasaka, T.
AU  - Kojima, E.
AU  - Pluda, J. M.
AU  - Hui, F. Jr
AU  - Yarchoan, R.
AU  - Mitsuya, H.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1995///
VL  - 28
IS  - 2
SP  - 133
EP  - 146
SN  - 0166-3542
AD  - Kavlick, M.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002701.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 134678-17-4. 
KW  - analogues
KW  - drug resistance
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lamivudine
KW  - nucleoside analogues
KW  - nucleosides
KW  - therapy
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 3TC
KW  - analogs
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - nucleoside analogs
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The Polycomb and trithorax group proteins of Drosophila: Trans-regulators of homeotic gene function.
AU  - Kennison, J. A.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1995///
VL  - 29
SP  - 289
EP  - 303
SN  - 0066-4197
AD  - Kennison, J. A.: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2785, USA.
N1  - Accession Number: 19970501287.  Publication Type: Journal Article.  Language: English.  Number of References: 82 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2  - The Polycomb and trithorax group genes encode trans-regulators of homeotic gene function in Drosophila. The Polycomb group genes encode transcriptional repressors, while the trithorax group proteins are positive factors required for homeotic gene function. Among the Polycomb group proteins, the POLYCOMB protein has been most extensively characterized. The POLYCOMB protein contains a chromodomain, a conserved domain found in a Drosophila protein with effects on position-effect variegation. Among the trithorax group proteins characterized, the BRAHMA protein appears to be a subunit of a protein complex conserved from yeast to man (the SNF/SWI complex) that modifies chromatin to facilitate the transcriptional activation by gene-specific DNA-binding proteins. The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins.
KW  - agricultural entomology
KW  - genes
KW  - genetics
KW  - homeotic genes
KW  - molecular genetics
KW  - proteins
KW  - regulation
KW  - reviews
KW  - arthropods
KW  - Drosophila
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Drosophilidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - biochemical genetics
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Porphyria cutanea tarda in hepatitis C virus-infected blood donors.
AU  - Conry-Cantilena, C.
AU  - Vilamidou, L.
AU  - Melpolder, J. C.
AU  - VanRaden, M.
AU  - Alter, H. J.
JO  - Journal of the American Academy of Dermatology
JF  - Journal of the American Academy of Dermatology
Y1  - 1995///
VL  - 32
IS  - 3
SP  - 512
EP  - 514
SN  - 0190-9622
AD  - Conry-Cantilena, C.: Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002869.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Public Health
N2  - A report of two cases.
KW  - blood donors
KW  - case reports
KW  - hepatitis C
KW  - human diseases
KW  - porphyria cutanea tarda
KW  - Maryland
KW  - North America
KW  - USA
KW  - hepatitis C virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection and quantitation of the glucuronoxylomannan-like polysaccharide antigen from clinical and nonclinical isolates of Trichosporon beigelii and implications for pathogenicity.
AU  - Lyman, C. A.
AU  - Devi, S. J. N.
AU  - Nathanson, J.
AU  - Frasch, C. E.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 1
SP  - 126
EP  - 130
SN  - 0095-1137
AD  - Lyman, C. A.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951201349.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - The amounts of antigen produced and the expression of O-acetyl epitopes from 35 T. beigelii strs. isolated from deep and superficial infections in patients in the USA were studied. By counterimmunoelectrophoresis, 10 of 10 isolates from deep infections were positive for polysaccharide, compared with 7 of 13 isolates from superficial infections (P=0.02). All 23 strs. tested were positive for polysaccharide when screened by immunodot. By enzyme immunoassay, the cross-reactive antigen produced by deep isolates (n=9) had a mean titre of 1:5500. In contrast, superficial isolates (n=22) produced significantly less antigen than the deep isolates (P&lt;0.001), with a mean titre of 1:700. Isolates from environmental sources (n=3) were similar to the superficial isolates, with a mean titre of 1:600. The mean concn of cross-reactive polysaccharide released by deep isolates and superficial isolates were 3.09±0.44 and 1.74±0.30 µg/ml, respectively, when measured by rocket immunoelectrophoresis (P=0.02). O-Acetyl epitopes were detected on polysaccharide from 8 of 9 T. beigelii strs. isolated from deep sources, while only 2 of 12 superficial isolates expressed detectable O-acetyl epitopes (P=0.01). It is concluded that while all isolates of T. beigelii tested were capable of producing glucuronoxylomannan-like cross-reactive antigen, pathogenic isolates produced significantly more antigen than superficial or environmental isolates. Significantly more pathogenic isolates than superficial or environmental isolates expressed antigen that was O acetylated.
KW  - antigens
KW  - cross reaction
KW  - hosts
KW  - human diseases
KW  - immunology
KW  - infections
KW  - mycoses
KW  - pathogenicity
KW  - polysaccharides
KW  - USA
KW  - man
KW  - Trichosporon
KW  - Trichosporon beigelii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - Trichosporon
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - complex carbohydrates
KW  - fungus
KW  - Hyphomycetes
KW  - immunogens
KW  - trichosporonosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - PCR amplification of rRNA intergenic spacer regions as a method for epidemiologic typing of Clostridium difficile.
AU  - Cartwright, C. P.
AU  - Stock, F.
AU  - Beekmann, S. E.
AU  - Williams, E. C.
AU  - Gill, V. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 1
SP  - 184
EP  - 187
SN  - 0095-1137
AD  - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnusson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19952002445.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Public Health
N2  - From January to March 1993, a suspected outbreak of antibiotic-associated diarrhoea occurred on a paediatric oncology ward of the Clinical Center Hospital at the National Institutes of Health. Isolates of Clostridium difficile obtained from 6 patients implicated in this outbreak were typed by both PCR amplification of rRNA intergenic spacer regions (PCR ribotyping) and restriction endonuclease analysis of genomic DNA. Comparable results were obtained with both methods; five of the 6 patients were infected with the same strain of Cl. difficile. Subsequent analysis of 102 of Cl. difficile isolates obtained from symptomatic patients throughout the Clinical Center revealed the existence of 41 distinct and reproducible PCR ribotypes. These data suggest that PCR ribotyping provides a discriminatory, reproducible, and simple alternative to conventional molecular approaches for typing strains of Cl. difficile.
KW  - diarrhoea
KW  - human diseases
KW  - infections
KW  - polymerase chain reaction
KW  - strains
KW  - Maryland
KW  - North America
KW  - USA
KW  - Clostridium difficile
KW  - man
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - diarrhea
KW  - PCR
KW  - scouring
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002445&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of increasing inoculum sizes of pathogenic filamentous fungi on MICs of antifungal agents by broth microdilution method.
AU  - Gehrt, A.
AU  - Peter, J.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 5
SP  - 1302
EP  - 1307
SN  - 0095-1137
AD  - Gehrt, A.: Mycology Unit, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951202337.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 1397-89-3, 2022-85-7, 84625-61-6, 22916-47-8.  Subject Subsets: Medical & Veterinary Mycology
N2  - The influence of different inoculum sizes on min. inhibitory concn (MIC) of amphotericin B, 5-fluorocytosine [flucytosine], itraconazole and miconazole was investigated by the broth microdilution method using 32 clinical isolates (8 Aspergillus fumigatus, 8 A. flavus, 5 Rhizopus arrhizus, 8 Pseudallescheria boydii and 3 Fusarium solani). Four inoculum sizes were studied: 1 × 10²-5 × 10², 1 × 10³-5 × 10³, 1 × 104-5 × 104 and 1 × 105-5 × 105 colony forming units (CFU)/ml. The NCCLS reference method for antifungal susceptibility testing in yeasts was modified and applied to filamentous fungi. The inoculum was spectrophotometrically adjusted and all tests were performed in buffered medium (RPMI 1640) at pH 7.0 with incubation at 35°C for 72 h. MIC were read at 24, 48 and 72 h. Amphotericin B showed a min. effect of inoculum size on MIC for all species with the exception of P. boydii (P&lt;0.05). A significant effect of inoculum size on MIC was observed with flucytosine, for which there was an increase of &gt;10-fold in MIC against all Aspergillus spp. between inoculum concn of 10² and 104 CFU/ml (P&lt;0.001). For itraconazole, the results showed a more species-dependent increase of MIC, especially for R. arrhizus and P. boydii. Miconazole, which was tested only with P. boydii, did not demonstrate a significant effect of inoculum size on MIC. It is concluded that the effect of inoculum size on MIC for filamentous fungi is dependent upon the organism and antifungal compound tested. Itraconazole and flucytosine demonstrated significant inoculum effects, while amphotericin B and miconazole showed comparatively minimum inoculum effects against pathogenic filamentous fungi. P. boydii and R. arrhizus showed the greatest inoculum effect.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - flucytosine
KW  - itraconazole
KW  - miconazole
KW  - techniques
KW  - Aspergillus flavus
KW  - Aspergillus fumigatus
KW  - fungi
KW  - Haematonectria haematococca
KW  - Mucoraceae
KW  - Pseudallescheria boydii
KW  - Rhizopus arrhizus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Fusarium
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Rhizopus
KW  - Mucoraceae
KW  - Mucorales
KW  - Mucoromycotina
KW  - Zygomycota
KW  - Haematonectria
KW  - 5-fluorocytosine
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Fusarium solani
KW  - Hyphomycetes
KW  - susceptibility testing
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of Microsporidia in stool specimens by using PCR and restriction endonucleases.
AU  - Fedorko, D. P.
AU  - Nelson, N. A.
AU  - Cartwright, C. P.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 7
SP  - 1739
EP  - 1741
SN  - 0095-1137
AD  - Fedorko, D. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960801066.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 9007-49-2.  Subject Subsets: Protozoology
N2  - A PCR-based assay was developed for the detection of Microspora in clinical specimens. A single primer pair complementary to conserved sequences of the small-subunit rRNA enabled amplification of DNA from the 4 major microsporan pathogens of humans: Encephalitozoon cuniculi, Encephalitozoon hellem, Enterocytozoon bieneusi and Septata intestinalis. The extraction method allowed PCR amplification of E. bieneusi and S. intestinalis DNA from sodium hypochlorite-treated stool specimens. Differentiation between E. bieneusi and S. intestinalis was accomplished by restriction endonuclease digestion of PCR products using PstI and HaeIII.
KW  - diagnosis
KW  - DNA
KW  - faeces
KW  - gastrointestinal diseases
KW  - human diseases
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - parasites
KW  - polymerase chain reaction
KW  - protozoal infections
KW  - restriction endonuclease analysis
KW  - restriction endonucleases
KW  - Encephalitozoon intestinalis
KW  - Enterocytozoon bieneusi
KW  - man
KW  - Microspora
KW  - protozoa
KW  - Encephalitozoon
KW  - Encephalitozoonidae
KW  - Microspora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Enterocytozoon
KW  - Enterocytozoonidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - deoxyribonucleic acid
KW  - feces
KW  - PCR
KW  - protozoal diseases
KW  - Septata intestinalis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diversity of DNA fingerprints in Cryptococcus neoformans.
AU  - Varma, A.
AU  - Swinne, D.
AU  - Staib, F.
AU  - Bennett, J. E.
AU  - Kwon-Chung, K. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 7
SP  - 1807
EP  - 1814
SN  - 0095-1137
AD  - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961201159.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - DNA fingerprint patterns of 156 C. neoformans isolates (26 AIDS patients, 46 non-AIDS patients and 40 environmental sources) from both varieties (126 C. neoformans var. neoformans and 30 C. neoformans var. gattii isolates) and from 7 countries were analysed by using the DNA probe UT-4p. Nine and 12 distinct DNA fingerprint patterns were observed for isolates of C. neoformans and C. neoformans var. gattii, respectively. No pattern was unique to AIDS patients, non-AIDS patients or the environment. Pattern II was observed more often in non-AIDS patients (8 of 23) than in AIDS patients (0 of 25). Pattern V was the most prevalent pattern (42 of 82) in clinical and environmental isolates. Isolates from 3 AIDS patients in Burundi and Zaire exhibited patterns identical to each other but different from those of isolates collected from their houses (dust of floors, walls) or a nearby pigeon coop. DNA fingerprint stability was determined for 53 isolates from 9 non-AIDS patients at different time intervals during 5 to 128 wk of antifungal therapy. For 8 patients, the fingerprint pattern was stable while the 9th may have had a mixed infection. Pattern II was observed in 4 of 9 patients, which was similar to 4 of 14 in other non-AIDS patients as reported here. In spite of the extensive pattern heterogeneity among 15 C. neoformans var. gattii isolates in Australia, the patterns observed in 7 California isolates were quite different from those in Australia. Among isolates of C. neoformans var. gattii, one fingerprint pattern (designated b) was observed in several countries of the Far East. The fingerprint patterns of 2 of 3 environmental isolates from Eucalyptus camaldulensis trees in Australia were identical to those of 2 of the 12 clinical isolates from that country.
KW  - acquired immune deficiency syndrome
KW  - contamination
KW  - cryptococcosis
KW  - DNA fingerprinting
KW  - epidemiology
KW  - genetics
KW  - genotypes
KW  - homes
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - opportunistic infections
KW  - predisposition
KW  - Australia
KW  - Burundi
KW  - California
KW  - Congo Democratic Republic
KW  - USA
KW  - Cryptococcus gattii
KW  - Cryptococcus neoformans
KW  - Eucalyptus
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus neoformans
KW  - Myrtaceae
KW  - Myrtales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - North America
KW  - America
KW  - AIDS
KW  - Cryptococcus neoformans var. gattii
KW  - european blastomycosis
KW  - fungus
KW  - United States of America
KW  - Zaire
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mycoplasma pneumoniae and Mycoplasma genitalium mixture in synovial fluid isolate.
AU  - Tully, J. G.
AU  - Rose, D. I.
AU  - Baseman, J. B.
AU  - Dallo, S. F.
AU  - Lazzell, A. L.
AU  - Davis, C. P.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 7
SP  - 1851
EP  - 1855
SN  - 0095-1137
AD  - Tully, J. G.: Mycoplasma Section, National Institute of Allergy and Infectious Diseases, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19952007130.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Public Health
N2  - A mycoplasma cultured from synovial fluid specimens from a patient with pneumonia and subsequent polyarthritis was identified initially as Mycoplasma pneumoniae. In retrospective studies, the culture was shown also to contain M. genitalium. In this paper, the laboratory techniques employed in the identification and separation of the 2 species are presented, and evidence to implicate post-infectious autoimmunity is provided. An increasing number of reports of M. genitalium in human tissue sites and difficulties in isolation and identification of the organism in the clinical laboratory suggest the need for more extensive application of rapid and specific detection systems for both M. genitalium and M. pneumoniae in the clinical laboratory.
KW  - differentiation
KW  - human diseases
KW  - immunofluorescence
KW  - man
KW  - Mycoplasma genitalium
KW  - Mycoplasma pneumoniae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycoplasma
KW  - Mycoplasmataceae
KW  - Mycoplasmatales
KW  - Mollicutes
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - fluorescent antibody technique
KW  - IFAT
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quantitative PCR for human herpesviruses 6 and 7.
AU  - Secchiero, P.
AU  - Zella, D.
AU  - Crowley, R. W.
AU  - Gallo, R. C.
AU  - Lusso, P.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 8
SP  - 2124
EP  - 2130
SN  - 0095-1137
AD  - Secchiero, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962003097.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref.
N2  - The authors developed a quantitative polymerase chain reaction (PCR) assay for the detection of human herpesvirus 6 (HHV-6) (variants A and B) and HHV-7 DNAs in clinical samples using a non-homologous internal standard (IS) for each virus that is coamplified with the wild-type target sequence in the same vial and with the same pair of primers. This method allows for a correction of the variability of efficiency of the PCR technique. A standard curve is constructed for each experiment by coamplification of known quantities of the cloned HHV-6 or HHV-7 target templates with the respective IS. Absolute quantitation of the test samples is then achieved by determining the viral target/IS ratio of the hybridization signals of the amplification products and plotting this value against the standard curve. Using this assay the authors quantitated the amount of HHV-6 or HHV-7 DNA in infected cell cultures and demonstrated an inhibitory effect of phosphobiformic acid on the replication of HHV-6 and HHV-7 in vitro. For the first clinical application of this procedure, the authors performed preliminary measurements of the loads of HHV-6 and HHV-7 in lymph nodes from patients with Hodgkin's disease and AIDS. They conclude that application of this quantitative PCR method should be helpful for elucidating the pathogenic roles of HHV-6 and HHV-7. [The validity of quantitation of HHV-6 and HHV-7 DNA in clinical specimens as an approach to distinguishing latent from active infection with these agents totally depends on, as these authors state, latency being "associated with a low viral burden". However, they supply no evidence to support this statement. Longitudinally, the level of virus load in an individual patient is likely to change with the natural history of the viral disease and during administration of antiviral chemotherapy. It remains to be proved whether the amount of viral load in every patient with latent HHV-6 or HHV-7 infection will always be lower than that in every patient with active infection with these agents. Recent studies with serial CMV DNA detection in urine by PCR suggested that renal transplant patients with active rather than latent infection had higher maximal viral loads, but there was much overlap between the viral DNA concentrations in different patients at other times. (Journal of General Virology 1995; 76: 309-319).] D.J. Morris.
KW  - diagnosis
KW  - human diseases
KW  - infections
KW  - lymph nodes
KW  - polymerase chain reaction
KW  - human herpesvirus 6
KW  - human herpesvirus 7
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - PCR and single-strand conformational polymorphism for recognition of medically important opportunistic fungi.
AU  - Walsh, T. J.
AU  - Francesconi, A.
AU  - Kasai, M.
AU  - Chanock, S. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1995///
VL  - 33
IS  - 12
SP  - 3216
EP  - 3220
SN  - 0095-1137
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, 20892 MD, USA.
N1  - Accession Number: 19951203445.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Polymerase chain reaction (PCR) has been shown to be useful for the detection of the presence of fungal DNA in both laboratory and clinical samples. Considerable interest has been focused on the utility of selecting universal primers, those that recognize constant regions among most medically important fungi. Once an amplicon, or piece of amplified DNA determined by the unique pair of oligonucleotide primers, has been generated, several different methods may be used to distinguish between genera and between species. The 2 major approaches have utilized differences in restriction enzyme digestion patterns or hybridization with specific probe. The application of single-strand conformational polymorphism (SSCP) as a technique to delineate the differences between fungal species and/or genera is described. Minor sequence variations in small single-stranded DNA cause subtle changes in conformation, allowing these strands to be separated on polyacrylamide gels by SSCP. A 197-bp fragment amplified from the 18S rRNA gene, common to all medically important fungi, was used. After amplification, the fragments were denatured and run on an acrylamide-glycerol gel at room temp. or 4°C for 4.5 or 4 h, respectively. Under room temp. conditions, the SSCP patterns for Candida albicans, C. tropicalis and C. parapsilosis were identical and all strains within each species demonstrated the same pattern. These patterns differed markedly from those of the genus Aspergillus. The SSCP patterns of major and minor bands at room temp. permitted distinction between strains of A. fumigatus and A. flavus. There was also consistency of the SSCP banding pattern among different strains of the same Aspergillus sp. The SSCP patterns for other medically important opportunistic fungi, such as Cryptococcus neoformans, Pseudallescheria boydii and Rhizopus arrhizus, were sufficiently unique to permit distinction from those of Candida albicans and A. fumigatus. It is concluded that the technique of PCR-SSCP provides a novel method by which to recognize and distinguish medically important opportunistic fungi and which has potential applications to molecular diagnosis, taxonomic classification, molecular epidemiology and elucidation of mechanisms of antifungal drug resistance.
KW  - identification
KW  - polymerase chain reaction
KW  - techniques
KW  - Aspergillus flavus
KW  - Aspergillus fumigatus
KW  - Candida albicans
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - Cryptococcus neoformans
KW  - Mucoraceae
KW  - Pseudallescheria boydii
KW  - Rhizopus arrhizus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Sordariomycetes
KW  - Rhizopus
KW  - Mucoraceae
KW  - Mucorales
KW  - Mucoromycotina
KW  - Zygomycota
KW  - fungus
KW  - Hyphomycetes
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) and International Cooperative Biodiversity Group (ICBG) programs.
AU  - Suffness, M.
AU  - Cragg, G. M.
AU  - Grever, M. R.
AU  - Grifo, F. J.
AU  - Johnson, G.
AU  - Mead, J. A. R.
AU  - Schepartz, S. A.
AU  - Venditti, J. M.
AU  - Wolpert, M.
A2  - Valeriote, F.
A2  - Pezzuto, J.
JO  - International Journal of Pharmacognosy
JF  - International Journal of Pharmacognosy
Y1  - 1995///
VL  - 33
IS  - SUPPL
SP  - 5
EP  - 16
SN  - 0925-1618
AD  - Suffness, M.: Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19960300453.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 2 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - The high interest in natural products as sources of pharmaceutical products led to the creation of the NCNPDDG programme by the National Cancer Institute with the goal of bringing together scientists from academia, industry and government in a focused effort for discovery of new drugs for cancer treatment. Similarly, the National Institutes of Health, the National Science Foundation, and the US Agency for International Development have joined together to form the ICBG programme to promote the goals of biodiversity conservation, economic development and pharmaceutical discovery. Both programmes are briefly described.
KW  - antineoplastic agents
KW  - antineoplastic properties
KW  - biodiversity
KW  - conservation
KW  - development agencies
KW  - government organizations
KW  - natural products
KW  - research
KW  - anti-neoplastic properties
KW  - cytotoxic agents
KW  - Drug discovery and development
KW  - studies
KW  - Plant Science (General) (FF000) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Non-food/Non-feed Plant Products (SS200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary intake changes associated with post-cyclone food aid in Western Somoa.
AU  - Galanis, D. J.
AU  - Chin-Hong, P. V.
AU  - McGarvey, S. T.
AU  - Messet, E.
AU  - Parkinson, D.
JO  - Ecology of Food and Nutrition
JF  - Ecology of Food and Nutrition
Y1  - 1995///
VL  - 34
IS  - 2
SP  - 137
EP  - 147
SN  - 0367-0244
AD  - Galanis, D. J.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951414151.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology; Rural Development
N2  - This study examines dietary intake responses to a food aid programme in Western Samoa, which consisted primarily of rice and flour supplements. Using a semi-quantitative food frequency questionnaire, intake estimates were made for 147 Samoans (72 men, 75 women; 25-55 years old), 5 months before and 8 months after a tropical cyclone. Study participants were from urban Apia (n=34) and 3 rural, more traditional villages (n=113). For the total sample, consumption of rice and pancakes more than doubled, and the contribution of these foods to total carbohydrate and energy intake increased about 3-fold (P&lt;0.0001). Significant decreases were noted for the nutrient contribution from breadfruit and coconut products. These dietary changes were significantly less in the urban sub-sample. These results indicate the food aid may have accelerated an existing modernizing trend in the diet of Samoans. The nutritional and economic implications are discussed within the context of Western Samoa.
KW  - diet studies
KW  - food aid
KW  - natural disasters
KW  - nutrition programmes
KW  - rural development
KW  - Samoa
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - Polynesia
KW  - Oceania
KW  - Pacific Islands
KW  - feeding programmes
KW  - feeding programs
KW  - food programs
KW  - nutrition programs
KW  - Western Samoa
KW  - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW  - Diet Studies (VV110) 
KW  - Consumer Economics (EE720) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.
AU  - Mazumder, A.
AU  - Gazit, A.
AU  - Levitzki, A.
AU  - Nicklaus, M.
AU  - Yung, J.
AU  - Kohlhagen, G.
AU  - Pommier, Y.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1995///
VL  - 34
IS  - 46
SP  - 15111
EP  - 15122
SN  - 0006-2960
AD  - Mazumder, A.: Laboratories of Molecular Pharmacology and Medicinal Chemistry, Division of Basic Science, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006413.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 9026-43-1. 
KW  - antiviral agents
KW  - antiviral properties
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - protein kinase
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - tyrphostins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of novel differentially expressed hepatic genes in cholesterol-fed rabbits by a non-targeted gene approach.
AU  - Remaley, A. T.
AU  - Schumacher, U. K.
AU  - Amouzadeh, H. R.
AU  - Brewer, H. B., Jr.
AU  - Hoeg, J. M.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1995///
VL  - 36
IS  - 2
SP  - 308
EP  - 314
SN  - 0022-2275
AD  - Remaley, A. T.: National Heart, Lung, and Blood Institute, National Institute of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951404532.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The effect of cholesterol on gene expression was investigated in differentially expressed genes from the polymerase chain reaction (PCR) based subtraction library prepared from the liver of chow fed and cholesterol fed rabbits. 9 upregulated and 4 downregulated cDNA fragments were isolated. As determined by Northern blot analysis, the expression of the isolated cDNAs began to change as early as the first week on the cholesterol rich diet or as late as 4 weeks, which corresponded with hepatic cholesterol accumulation. 3 of the cDNAs were identified by DNA sequence homology, whereas the remaining cDNAs had no significant homology match. CYP1A1, a cytochrome P450 isoenzyme, was found to be downregulated in hepatocytes by cholesterol feeding. Osteopontin and Mac-2, which are produced by macrophages, were found to be upregulated in Kupffer cells by cholesterol feeding. Overall results demonstrate the usefulness of the subtraction library approach for identifying new candidate genes for exploring the pathogenesis of atherosclerosis.
KW  - atherosclerosis
KW  - cholesterol
KW  - gene expression
KW  - genes
KW  - identification
KW  - intake
KW  - liver
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Maternal-fetal interactions affect growth of human immunodeficiency virus type 1 transgenic mice.
AU  - Franks, R. R.
AU  - Ray, P. E.
AU  - Babbott, C. C.
AU  - Bryant, J. L.
AU  - Notkins, A. L.
AU  - Santoro, T. J.
AU  - Klotman, P. E.
JO  - Pediatric Research
JF  - Pediatric Research
Y1  - 1995///
VL  - 37
IS  - 1
SP  - 56
EP  - 63
SN  - 0031-3998
AD  - Franks, R. R.: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003111.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref.
KW  - animal models
KW  - HIV infections
KW  - interactions
KW  - maternal transmission
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus infections
KW  - mother to child transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003111&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occupational risks for cutaneous melanoma among men in Sweden.
AU  - Linet, M. S.
AU  - Malker, H. S. R.
AU  - Chow WongHo
AU  - McLaughlin, J. K.
AU  - Weiner, J. A.
AU  - Stone, B. J.
AU  - Ericsson, J. L. E.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of Occupational and Environmental Medicine
JF  - Journal of Occupational and Environmental Medicine
Y1  - 1995///
VL  - 37
IS  - 9
SP  - 1127
EP  - 1135
AD  - Linet, M. S.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, EPN 415, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19962004976.  Publication Type: Journal Article.  Language: English.  Number of References: 81 ref. Subject Subsets: Public Health
N2  - A population-based linked-registry was used to evaluate incidence of malignant melanoma of the skin among Swedish men by industry and occupation. There were 3850 cutaneous melanoma cases identified in the 19-year follow-up of men employed in 1960. New associations were observed for men employed in the breweries and malt-processing industry and in shoe fabrication from leather and skins. Several findings supported associations previously reported in other countries, including an excess risk among workers in basic chemical production and the printing industry and among professional, technical, and white-collar workers. Risk overall was not increased among farmers, despite a significant excess of melanoma of the face, neck, and scalp. Although this linked registry analysis lacked information about specific agents, duration of employment, and occupational and recreational sun exposures, it did provide leads for new associations and confirmed previous ones. Nevertheless, because of these limitations, aetiological clues must be interpreted cautiously.
KW  - cutaneous melanoma
KW  - epidemiology
KW  - human diseases
KW  - men
KW  - neoplasms
KW  - occupational health
KW  - occupations
KW  - risk factors
KW  - workers
KW  - Europe
KW  - Sweden
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmacokinetics of michellamine B, a naphthylisoquinoline alkaloid with in vitro activity against human immunodeficiency virus types 1 and 2, in the mouse and dog.
AU  - Supko, J. G.
AU  - Malspeis, L.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 1
SP  - 9
EP  - 14
SN  - 0066-4804
AD  - Supko, J. G.: Laboratory of Pharmaceutical Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701, USA.
N1  - Accession Number: 19952005309.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - Concentrations of the naphthylisoquinoline alkaloid that were effective against HIV-1 and HIV-2 in vitro were achievable in mice and dogs after intravenous administration without toxicity. Metabolic pathways could not be elucidated.
KW  - alkaloids
KW  - antiviral agents
KW  - human immunodeficiency viruses
KW  - isoquinoline alkaloids
KW  - natural products
KW  - pharmacokinetics
KW  - plant products
KW  - toxicity
KW  - animals
KW  - dogs
KW  - man
KW  - mice
KW  - eukaryotes
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Muridae
KW  - rodents
KW  - crop products
KW  - human immunodeficiency virus
KW  - michellamine B
KW  - naphthylisoquinolines
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms.
AU  - McMahon, J. B.
AU  - Currens, M. J.
AU  - Gulakowski, R. J.
AU  - Buckheit, R. W. Jr
AU  - Lackman-Smith, C.
AU  - Hallock, Y. F.
AU  - Boyd, M. R.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 2
SP  - 484
EP  - 488
SN  - 0066-4804
AD  - McMahon, J. B.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19952005316.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - A new dimeric alkaloid (extracted from the aerial parts of the tropical vine Ancistrocladus korupensis) was found to act at two stages of the HIV life cycle. It inhibited RTase and human DNA polymerases α and β as well as cell fusion and syncytium formation when added up to 48 h after acute infection, but complete inhibition of viral replication occurred only when it was added immediately after infection. Fully established cell infections were not affected by michellamine B.
KW  - alkaloids
KW  - antiviral agents
KW  - antiviral plants
KW  - antiviral properties
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - natural products
KW  - pharmacokinetics
KW  - plant products
KW  - toxicity
KW  - Ancistrocladaceae
KW  - Ancistrocladus korupensis
KW  - man
KW  - plants
KW  - Theales
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Ancistrocladus
KW  - Ancistrocladaceae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - anti-viral properties
KW  - crop products
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - michellamine B
KW  - naphthylisoquinolines
KW  - officinal plants
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Plant Composition (FF040) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria.
AU  - Polis, M. A.
AU  - Spooner, K. M.
AU  - Baird, B. F.
AU  - Manischewitz, J. F.
AU  - Jaffe, H. S.
AU  - Fisher, P. E.
AU  - Falloon, J.
AU  - Davey, R. T., Jr.
AU  - Kovacs, J. A.
AU  - Walker, R. E.
AU  - Whitcup, S. M.
AU  - Nussenblatt, R. B.
AU  - Lane, H. C.
AU  - Masur, H.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 4
SP  - 882
EP  - 886
SN  - 0066-4804
AD  - Polis, M. A.: National Institute of Allergy and Infectious Diseases, Building 10, Room 11C103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952006120.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 113852-37-2. 
KW  - acquired immune deficiency syndrome
KW  - adverse effects
KW  - analogues
KW  - antiviral agents
KW  - cidofovir
KW  - HIV infections
KW  - human diseases
KW  - infections
KW  - nucleotides
KW  - pharmacokinetics
KW  - therapy
KW  - toxicity
KW  - treatment
KW  - cytomegalovirus
KW  - man
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - AIDS
KW  - analogs
KW  - human immunodeficiency virus infections
KW  - nucleotide analogues
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006120&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Therapeutic monitoring of experimental invasive pulmonary aspergillosis by ultrafast computerized tomography, a novel, noninvasive method for measuring responses to antifungal therapy.
AU  - Walsh, T. J.
AU  - Garrett, K.
AU  - Feuerstein, E.
AU  - Girton, M.
AU  - Allende, M.
AU  - Bacher, J.
AU  - Francesconi, A.
AU  - Schaufele, R.
AU  - Pizzo, P. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 5
SP  - 1065
EP  - 1069
SN  - 0066-4804
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951202384.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The course of pulmonary infiltrates was monitored by serial ultrafast computerized tomography (UFCT) in persistently granulocytopenic rabbits with experimental invasive pulmonary aspergillosis. The course of pulmonary lesions measured by serial UFCT scans was compared with those measured by conventional chest radiography, histopathological resolution of lesions and microbiological clearance of Aspergillus fumigatus. Treatment groups included either amphotericin B colloidal dispersion in dosages of 1, 5 and 10 mg/kg of body wt daily intravenously or conventional desoxycholate amphotericin B at 1 mg/kg daily intravenously. Therapeutic monitoring of pulmonary lesions by UFCT demonstrated a significant dose-response relationship. Lesions continued to progress in untreated controls, whereas lesions in treated rabbits initially increased and then decreased in response to antifungal therapy in a dosage-dependent manner (P≤0.05 to P≤0.005, depending upon the groups compared). This same trend of resolution of lesions in response to antifungal therapy was also demonstrated by post-mortem examination and by microbiological clearance of the organism. The data indicated that amphotericin B colloidal dispersion at 5 and 10 mg/kg daily exerted a more rapid rate of clearance of lesions than conventional amphotericin B. UFCT was more sensitive than conventional chest radiography in detecting lesions due to invasive pulmonary aspergillosis (P&lt;0.05 to P&lt;0.005, depending upon the groups compared). These findings established a correlation among UFCT-defined lesions, microbiological response and resolution of pathologically defined lesions in experimental invasive pulmonary aspergillosis. It is concluded that aerial monitoring of UFCT-defined lesions of aspergillosis provides a novel system for determining the antifungal response of organism-mediated tissue injury.
KW  - administration
KW  - amphotericin B
KW  - antifungal agents
KW  - aspergillosis
KW  - computed tomography
KW  - diagnosis
KW  - drug formulations
KW  - drug therapy
KW  - experimental infections
KW  - infections
KW  - lipids
KW  - lungs
KW  - therapy
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - lipins
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202384&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Activities of amphotericin B and antifungal azoles alone and in combination against Pseudallescheria boydii.
AU  - Walsh, T. J.
AU  - Peter, J.
AU  - McGough, D. A.
AU  - Fothergill, A. W.
AU  - Rinaldi, M. G.
AU  - Pizzo, P. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 6
SP  - 1361
EP  - 1364
SN  - 0066-4804
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200300.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 1397-89-3, 86386-73-4, 84625-61-6, 22916-47-8.  Subject Subsets: Medical & Veterinary Mycology
N2  - The in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole and fluconazole, against P. boydii, was determined. Combinations of amphotericin B and antifungal azoles were synergistic, additive or indifferent in their interaction against P. boydii. Antagonism was not observed.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - azoles
KW  - drug synergy
KW  - fluconazole
KW  - itraconazole
KW  - miconazole
KW  - synergism
KW  - Pseudallescheria boydii
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - susceptibility testing
KW  - synergy
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200300&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - NP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces species.
AU  - Chokekijchai, S.
AU  - Kojima, E.
AU  - Anderson, S.
AU  - Nomizu, M.
AU  - Tanaka, M.
AU  - Machida, M.
AU  - Date, T.
AU  - Toyota, K.
AU  - Ishida, S.
AU  - Watanabe, K.
AU  - Yoshioka, H.
AU  - Roller, P. P.
AU  - Murakami, K.
AU  - Mitsuya, H.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 10
SP  - 2345
EP  - 2347
SN  - 0066-4804
AD  - Chokekijchai, S.: Correspondence address: H, Mitsuya, Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008782.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - cell fusion
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibitors
KW  - oligopeptides
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008782&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogues in resting and activated peripheral blood mononuclear cells.
AU  - Shirasaka, T.
AU  - Chokekijchai, S.
AU  - Yamada, A.
AU  - Gosselin, G.
AU  - Imbach, J. L.
AU  - Mitsuya, H.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 11
SP  - 2555
EP  - 2559
SN  - 0066-4804
AD  - Shirasaka, T.: Correspondence address: H. Mitsuya, Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962000613.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
KW  - activity
KW  - analogues
KW  - antiviral agents
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nucleoside analogues
KW  - nucleosides
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - analogs
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000613&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates.
AU  - Blaney, S. M.
AU  - Daniel, M. J.
AU  - Harker, A. J.
AU  - Godwin, K.
AU  - Balis, F. M.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1995///
VL  - 39
IS  - 12
SP  - 2779
EP  - 2782
SN  - 0066-4804
AD  - Blaney, S. M.: The Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007045.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 7841-89-2. 
KW  - animal models
KW  - dideoxycytidine
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pharmacokinetics
KW  - Macaca
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007045&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Are there alternative avian influenza viruses for generation of stable attenuated avian-human influenza A reassortant viruses?
AU  - Subbarao, K.
AU  - Webster, R. G.
AU  - Yoshihiro Kawaoka
AU  - Murphy, B. R.
JO  - Virus Research
JF  - Virus Research
Y1  - 1995///
VL  - 39
IS  - 2/3
SP  - 105
EP  - 118
SN  - 0168-1702
AD  - Subbarao, K.: Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 106, 7 Center Drive MSC 0720, Bethesda, MD, USA.
N1  - Accession Number: 19962213413.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Veterinary Science
KW  - avian influenza
KW  - avian influenza A viruses
KW  - avian influenza viruses
KW  - human diseases
KW  - influenza a
KW  - influenza viruses
KW  - live vaccines
KW  - viral diseases
KW  - Influenza A virus
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthomyxoviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Influenzavirus A
KW  - attenuated vaccines
KW  - avian influenzavirus
KW  - bird flu
KW  - bird grippe
KW  - bird influenza
KW  - fowl plague virus
KW  - influenzavirus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962213413&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Helicobacter pylori infection. A reversible cause of hypergastrinemia and hyperchlorhydria which may mimic Zollinger-Ellison syndrome.
AU  - Metz, D. C.
AU  - Weber, H. C.
AU  - Orbuch, M.
AU  - Strader, D. B.
AU  - Lubensky, I. A.
AU  - Jensen, R. T.
JO  - Digestive Diseases and Sciences
JF  - Digestive Diseases and Sciences
Y1  - 1995///
VL  - 40
IS  - 1
SP  - 153
EP  - 159
SN  - 0163-2116
AD  - Metz, D. C.: National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952002520.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Public Health
N2  - The cases of 2 males, aged 13 years and 34 years, from Maryland, USA.
KW  - case reports
KW  - human diseases
KW  - infection
KW  - infections
KW  - stomach
KW  - zollinger-ellison syndrome
KW  - Maryland
KW  - North America
KW  - USA
KW  - Helicobacter pylori
KW  - man
KW  - Helicobacter
KW  - Helicobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - hyperacidity (agricola)
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002520&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Distribution of genetic diversity in relation to chromosomal inversions in the malaria mosquito Anopheles gambiae.
AU  - Mathiopoulos, K. D.
AU  - Lanzaro, G. C.
JO  - Journal of Molecular Evolution
JF  - Journal of Molecular Evolution
Y1  - 1995///
VL  - 40
IS  - 6
SP  - 578
EP  - 584
SN  - 0022-2844
AD  - Mathiopoulos, K. D.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960500902.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - The authors compared the genetic variation of areas inside and outside inversions in 2 distinct inversion karyotypes of A. gambiae. 35 cDNA clones were mapped on the 5 arms of the A. gambiae chromosomes with divisional probes. 16 of these clones, localized both inside and outside inversions of chromosome 2, were used as probes in order to determine the nucleotide diversity of different parts of the genome in the 2 inversion karyotypes. It was observed that the sequence diversity inside the inversion is &gt;3-fold lower than in areas outside the inversion and that the degree of divergence increases gradually at loci at increasing distance from the inversion. To interpret the data, the authors present a selectionist and a stochastic model, both of which point to a relative recent origin of the studied inversion and may suggest differences between the evolutionary history of inversions in Anopheles and Drosophila species.
KW  - chromosome inversion
KW  - clones
KW  - cytogenetics
KW  - DNA
KW  - genetics
KW  - inversion polymorphism
KW  - models
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500902&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Candida glabrata, Candida krusei, non-albicans Candida spp., and other fungal organisms in a sixty-bed national cancer center in 1989-1993: no association with the use of fluconazole.
AU  - Kunová, A.
AU  - Trupl, J.
AU  - Špánik, S.
AU  - Drgona, L.
AU  - Šufliarsky, J.
AU  - Lacka, J.
AU  - Studená, V.
AU  - Hlaváčová, E.
AU  - Studená, M.
AU  - Kukučková, E.
AU  - Kollár, T.
AU  - Pichna, P.
AU  - Oravcová, E.
AU  - Krčméry, K., Jr.
JO  - Chemotherapy (Basel)
JF  - Chemotherapy (Basel)
Y1  - 1995///
VL  - 41
IS  - 1
SP  - 39
EP  - 44
SN  - 0009-3157
AD  - Kunová, A.: Department of Microbiology, National Cancer Institute, Bratislava, Slovakia.
N1  - Accession Number: 19951201775.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - During 1989-1993, the incidence of C. krusei and other non-albicans Candida spp. was analysed at the National Cancer Center, Bratislava, Slovakia. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%. After introduction of fluconazole into prophylaxis in acute leukaemia in 1991, the incidence of C. krusei was 12.7%. After 3 yr of fluconazole use in therapy and prophylaxis, the incidence of C. krusei in 1993 was 14.8%, which was lower than before fluconazole was introduced in Slovakia. 97.6% of all isolated fungi were yeasts and 2.4% were moulds. Among yeasts, the most frequently isolated pathogen was C. albicans with 64.3% in 1989 and 74.2% in 1993 followed by C. krusei with 21.2% in 1992 and 16.5% in 1989, but 14.8% in 1993. C. tropicalis and C. glabrata [Torulopsis glabrata] were isolated with frequencies of 9.03% in 1989 and 2.7% in 1993. Among the moulds, Aspergillus spp. were most frequently isolated. It is concluded that of these mycologically proven fungal infections confirmed by positive blood cultures or biopsies, C. albicans and Aspergillus spp. were the most common causative organisms.
KW  - aspergillosis
KW  - candidosis
KW  - drug therapy
KW  - epidemiology
KW  - fluconazole
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - prophylaxis
KW  - therapy
KW  - Slovakia
KW  - Aspergillus
KW  - Candida
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida tropicalis
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Candida
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Torulopsis
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - cancers
KW  - Candida krusei
KW  - candidiasis
KW  - chemotherapy
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201775&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration.
AU  - Yanagihara, R.
AU  - Saitou, N.
AU  - Nerurkar, V. R.
AU  - Song, K. J.
AU  - Bastian, I.
AU  - Franchini, G.
AU  - Gajdusek, D. C.
JO  - Cellular and Molecular Biology
JF  - Cellular and Molecular Biology
Y1  - 1995///
VL  - 41
IS  - SUP 1
SP  - S145
EP  - S161
SN  - 0145-5680
AD  - Yanagihara, R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 36, Rm. 5B-21, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005475.  Publication Type: Journal Article.  Language: English.  Number of References: 111 ref. Subject Subsets: Tropical Diseases
N2  - Phylogenetic trees based on selected regions of the gag, pol, env and pX genes of HTLV-I from widely separated geographical regions and of simian T-cell lymphotropic virus type I (STLV-I) from African and Asian catarrhines, constructed using the neighbour-joining and maximum parsimony methods, indicated that the Australo-Melanesian and cosmopolitan strains of HTLV-I have evolved along separate geographically dependent lineages, with African STLV-I strains clustering with cosmopolitan HTLV-I strains and Asian STLV-I strains diverging from the common ancestral virus before the Australo-Melanesian HTLV-I strains. When viewed within the context of non-human primate evolution and human occupation of Australia and Melanesia, the rate of molecular change of HTLV-I and STLV-I is approximately 2.5-6.8 × 10-7 substitutions per site per year. Overall, the sequence and phylogenetic analyses are in accord with interspecies virus transmission among non-human primates, as well as between non-human primates and humans, with independent evolution of HTLV-I in Southeast Asia and in Africa, and with dissemination of HTLV-I by forced or voluntary movements of human populations. The immunosuppressive and T-cell activation properties of HTLV-I places at added risk these Australian Aboriginal and Melanesian populations, some of which are in imminent threat of infection with human immunodeficiency virus type 1.
KW  - evolution
KW  - HTLV infections
KW  - molecular biology
KW  - nucleotide sequences
KW  - phylogeny
KW  - Africa
KW  - Asia
KW  - Melanesia
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - retroviridae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Australasia
KW  - Oceania
KW  - Pacific Islands
KW  - DNA sequences
KW  - gene sequences
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005475&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of N-acetyl-β-hexosaminidase from Acanthamoeba castellanii.
AU  - Baldwin, K. M.
AU  - Bowers, B.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1995///
VL  - 42
IS  - 3
SP  - 237
EP  - 242
SN  - 1066-5234
AD  - Baldwin, K. M.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, Bldg. 3, Rm B1-22, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950808083.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 9027-52-5.  Subject Subsets: Protozoology
N2  - The lysosomal enzyme N-acetyl-β-hexosaminidase (βhex) was purified from Acanthamoeba castellanii growth medium by a 3 step procedure. The enzyme was precipitated with ammonium sulfate, partially purified on a DE52 column and purified to homogeneity on an affinity column. The purified βhex appeared to be a monomer of 58 000 MW with an isoelectric point of ~ 5.8. The enzyme activity in growth medium was stable for several months. The purified βhex was enzymatically deglycosylated and injected into 2 rabbits to make polyclonal antibodies. One antiserum was specific for βhex, but the other stained many bands on immunoblots of whole A. castellanii cell preparations. Using fluorescently-labelled secondary antibodies, it was shown that both antisera stained digestive vacuoles in the cytoplasm but did not stain the contractile vacuole. The multi-specific antiserum had high avidity for βhex but also stained the carbohydrate portion of other molecules. These other molecules may also be lysosomal enzymes since the activity of several other lysosomal enzymes was partially immunoprecipitable with the antiserum. These antibodies could be used to study traffic patterns among the variety of vacuolar structures in Acanthamoeba cytoplasm.
KW  - antibodies
KW  - beta-n-acetylhexosaminidase
KW  - biochemistry
KW  - cytoplasm
KW  - enzymes
KW  - lysosomes
KW  - organelles
KW  - parasites
KW  - purification
KW  - vacuoles
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - hexosaminidase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808083&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - YI-S, a casein-free medium for axenic cultivation of Entamoeba histolytica, related Entamoeba, Giardia intestinalis and Trichomonas vaginalis.
AU  - Diamond, L. S.
AU  - Clark, C. G.
AU  - Cunnick, C. C.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1995///
VL  - 42
IS  - 3
SP  - 277
EP  - 278
SN  - 1066-5234
AD  - Diamond, L. S.: Laboratory of Parasitic Diseases, NIAID, Bldg 4, Rm 126, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950808087.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 9000-71-9.  Subject Subsets: Protozoology
N2  - Pancreatic digests of casein are major ingredients of media used in the axenic cultivation of lumen-dwelling parasitic protozoa, especially Entamoeba spp., Giardia intestinalis and trichomonads, including Trichomonas vaginalis. The digest used almost exclusively in the development of these media, Medo-Peptone (Trypticase BBL), has not been available since 1981. Tests of similar type digests have revealed none equal to Medo-Peptone, and it has become increasingly difficult to obtain new batches which will support even modest growth of E. histolytica. A casein-free medium (YI-S), consisting of a nutrient broth, vitamin mixture and serum, has been developed in response to this problem and is recommended as a replacement for the casein-dependent medium TYI-S-33.
KW  - casein
KW  - cell culture
KW  - culture media
KW  - culture techniques
KW  - in vitro culture
KW  - parasites
KW  - Entamoeba
KW  - Entamoeba histolytica
KW  - Giardia duodenalis
KW  - Giardia intestinalis
KW  - protozoa
KW  - Trichomonas vaginalis
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Trichomonas
KW  - Trichomonadidae
KW  - Trichomonadida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Other Invertebrate Culture (Not Aquaculture) (LL030) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808087&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of iron deficient anemia in infant rhesus macaques.
AU  - Kriete, M. F.
AU  - Champoux, M.
AU  - Suomi, S. J.
JO  - Laboratory Animal Science
JF  - Laboratory Animal Science
Y1  - 1995///
VL  - 45
IS  - 1
SP  - 15
EP  - 21
SN  - 0023-6764
AD  - Kriete, M. F.: National Eye Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19952208524.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 7439-89-6.  Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science; Animal Nutrition; Human Nutrition
N2  - A retrospective analysis of complete blood count data obtained from 56 rhesus macaque infants over a 5-month period was conducted. 14 infants were exclusively dam-reared, and 42 were nursery-reared. By 60 days of age, erythrocyte indices were lower in the dam-reared monkeys than in the nursery-reared animals. Between 90 to 150 days of age, an apparent iron deficiency anaemia developed in the dam-reared infants only. This anaemia was characterized as a microcytic, hypochromic anaemia. The time of onset of anaemia was comparable developmentally to that observed in exclusively breast-fed human infants. At no time were these infants clinically or behaviourally affected by the anaemia. Haematological status of the dams did not correlate with that of their infants. It could not be determined whether dam's parity was predictive of the development of anaemia in the infant. These observed phenomena in rhesus monkeys may serve as a potential non-human primate model for the anaemia that is observed in exclusively breast-fed human infants.
KW  - anaemia
KW  - artificial rearing
KW  - blood disorders
KW  - breast feeding
KW  - deficiency
KW  - deficiency diseases
KW  - disease models
KW  - diseases
KW  - infants
KW  - iron
KW  - iron deficiency anaemia
KW  - laboratory animals
KW  - trace elements
KW  - wild animals
KW  - Macaca
KW  - man
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - anemia
KW  - blood diseases
KW  - haematologic disorders
KW  - hand rearing
KW  - hematologic disorders
KW  - iron deficiency anemia
KW  - microelements
KW  - Laboratory Animal Science (LL040) 
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952208524&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spiroplasma ixodetis sp. nov., a new species from Ixodes pacificus ticks collected in Oregon.
AU  - Tully, J. G.
AU  - Rose, D. L.
AU  - Yunker, C. E.
AU  - Carle, P.
AU  - Bové, J. M.
AU  - Williamson, D. L.
AU  - Whitcomb, R. F.
JO  - International Journal of Systematic Bacteriology
JF  - International Journal of Systematic Bacteriology
Y1  - 1995///
VL  - 45
IS  - 1
SP  - 23
EP  - 28
SN  - 0020-7713
AD  - Tully, J. G.: Mycoplasma Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Frederick Cancer Research Facility, Frederick, MD 21702, USA.
N1  - Accession Number: 19950502477.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A total of 8 strains of mollicutes was isolated from pooled suspensions prepared from I. pacificus collected in Oregon, USA. Morphologic examination by electron and dark-field microscopic techniques showed that each strain consisted of a mixture of motile, tightly coiled helical cells, small coccoid cells with diameters ranging from 300 to 500 nm, and pleomorphic, straight or branched filamentous forms. All cellular forms were surrounded by a single cytoplasmic membrane, and there was no evidence of a cell wall. The organisms were filtered and fastidious in their growth requirements. The optimum temperature for growth was 30°C, but multiplication occurred at temperatures ranging from 23 to 32°C. The strains catabolized glucose but did not hydrolyse arginine or urea. The genome size of Y32T (T = type strain) was 2220 kbp, and the DNA base composition (guanine-plus-cytosine content) of this organism was 25±1 mol%. The 8 isolates were serologically related to each other but were not related to 37 other type or representative strains belonging to the genus Spiroplasma. Strain Y32 (= ATCC 33835) is the type strain of S. ixodetis sp. nov.
KW  - new species
KW  - symbionts
KW  - taxonomy
KW  - Oregon
KW  - USA
KW  - Acari
KW  - Arachnida
KW  - Entomoplasmatales
KW  - Ixodes pacificus
KW  - Ixodidae
KW  - Mollicutes
KW  - Spiroplasma
KW  - Spiroplasma ixodetis
KW  - Spiroplasmataceae
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Mollicutes
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Spiroplasmataceae
KW  - Entomoplasmatales
KW  - Spiroplasma
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - systematics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell lymphotropic virus type I in Iranian-born Mashhadi Jews: genetic and phylogenetic evidence for common source of infection.
AU  - Nerurkar, V. R.
AU  - Achiron, A.
AU  - Song, K. J.
AU  - Melland, R. R.
AU  - Pinhas-Hamiel, O.
AU  - Melamed, E.
AU  - Shohat, B.
AU  - Yanagihara, R.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1995///
VL  - 45
IS  - 4
SP  - 361
EP  - 366
SN  - 0146-6615
AD  - Nerurkar, V. R.: Correspondence address: R. Yanagihara, National Institutes of Health, Bldg. 36, Rm. 5B21, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009640.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
KW  - epidemiology
KW  - htlv-I infections
KW  - human diseases
KW  - phylogeny
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009640&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The U-shaped association between body mass index and mortality: relationship with weight gain in a native American population.
AU  - Hanson, R. L.
AU  - McCance, D. R.
AU  - Jacobsson, L. T. H.
AU  - Narayan, K. M. V.
AU  - Nelson, R. G.
AU  - Pettitt, D. J.
AU  - Bennett, P. H.
AU  - Knowler, W. C.
JO  - Journal of Clinical Epidemiology
JF  - Journal of Clinical Epidemiology
Y1  - 1995///
VL  - 48
IS  - 7
SP  - 903
EP  - 916
SN  - 0895-4356
AD  - Hanson, R. L.: Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550E. Indian School Road, Phoenix, AZ 85014, USA.
N1  - Accession Number: 19951409494.  Publication Type: Journal Article.  Language: English.  Number of References: 86 ref. Subject Subsets: Human Nutrition
N2  - To determine whether weight loss explains high mortality rates in those with a low body mass index (BMI), the relationship between BMI, rate of weight gain and mortality were examined in 814 diabetic and 1814 nondiabetic Pima Indians in a longitudinal survey with a mean duration of follow-up of 8.1 years. The participants had had at least 2 examinations after the age of 20 years. BMI showed a U-shaped relationship with mortality rates in men, while an inverse relationship was seen in women. Subjects who were losing weight had higher mortality rates that those who were gaining. However, excess mortality among the lightest subjects was present among those who were gaining weight. Among nondiabetic subjects, the mortality ratio (MR) for BMI &lt;25 compared with 30-35 kg/m² was 1.5 unadjusted for weight gain, while the adjusted MR was 1.3. Weight loss, which may reflect underlying illness, was associated with high mortality rates in Pima Indians, but this did not fully account for the high mortality in the lightest individuals.
KW  - American Indians
KW  - body measurements
KW  - diabetes
KW  - ethnic groups
KW  - mortality
KW  - obesity
KW  - weight gain
KW  - weight losses
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - death rate
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409494&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of human immunodeficiency virus type-1 integrase by curcumin.
AU  - Mazumder, A.
AU  - Raghaven, K.
AU  - Weinstein, J.
AU  - Kohn, K. W.
AU  - Pommier, Y.
JO  - Biochemical Pharmacology
JF  - Biochemical Pharmacology
Y1  - 1995///
VL  - 49
IS  - 8
SP  - 1165
EP  - 1170
SN  - 0006-2952
AD  - Mazumder, A.: Correspondence address: Y. Pommier, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962002085.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 458-37-7.  Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
KW  - antiviral properties
KW  - curcumin
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - phenylpropanoids
KW  - structure
KW  - turmeric
KW  - Curcuma longa
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Curcuma
KW  - Zingiberaceae
KW  - Zingiberales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - anti-viral properties
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002085&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enhancement by hydroxyurea of the anti-human immunodeficiency virus type 1 potency of 2′-Β-fluoro-2′,3′-dideoxyadenosine in peripheral blood mononuclear cells.
AU  - Gao, W. Y.
AU  - Mitsuya, H.
AU  - Driscoll, J. S.
AU  - Johns, D. G.
JO  - Biochemical Pharmacology
JF  - Biochemical Pharmacology
Y1  - 1995///
VL  - 50
IS  - 2
SP  - 274
EP  - 276
SN  - 0006-2952
AD  - Gao, W. Y.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A24, Bethesda, MD 20982, USA.
N1  - Accession Number: 19962001911.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 69655-05-6, 127-07-1. 
KW  - antiviral agents
KW  - didanosine
KW  - HIV infections
KW  - human diseases
KW  - hydroxycarbamide
KW  - inhibitors
KW  - molecular biology
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dideoxyinosine
KW  - fluoro-dideoxyadenosine
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - hydroxyurea
KW  - mononuclear cells
KW  - peripheral blood
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001911&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence and phylogenetic analyses of human T cell lymphotropic virus type I from a Brazilian woman with adult T cell leukemia: comparison with virus strains from South America and the Caribbean basin.
AU  - Song, K. J.
AU  - Nerurkar, V. R.
AU  - Pereira-Cortez, A. J.
AU  - Yamamoto, M.
AU  - Taguchi, H.
AU  - Miyoshi, I.
AU  - Yanagihara, R.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1995///
VL  - 52
IS  - 1
SP  - 101
EP  - 108
SN  - 0002-9637
AD  - Song, K. J.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952004541.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Tropical Diseases
N2  - To clarify the genetic and phylogenetic relationship between an HTLV-I strain isolated from a Brazilian woman with adult T cell leukaemia and viral isolates from elsewhere in South America and from other geographical regions, selected regions of the gag, pol, env, and pX genes were amplified and directly sequenced. The overall sequence similarities between the Brazil-R-1 strain and the Japanese prototype ATK strain were 98.7% based on 1295 nucelotides and 99.1% based on 429 amino acids. Phylogenetic analysis indicated that strain Brazil-R-1 clustered with other Brazilian and South American HTLV-I isolates and was more closely related to Caribbean isolates from Martinique and Guadeloupe than to virus strains from other geographical regions. These data suggest a common source of HTLV-I infection in the Caribbean basin and South America.
KW  - geographical variation
KW  - human diseases
KW  - infections
KW  - strains
KW  - Brazil
KW  - Caribbean
KW  - South america
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - HTLV-BLV group
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004541&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neurocysticercosis and performance on neuropsychologic tests: a family study in Ecuador.
AU  - Levav, M.
AU  - Mirsky, A. F.
AU  - Cruz, M. E.
AU  - Cruz, I.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1995///
VL  - 53
IS  - 5
SP  - 552
EP  - 557
SN  - 0002-9637
AD  - Levav, M.: Section on Clinical and Experimental Neuropsychology, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1366, USA.
N1  - Accession Number: 19960800931.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - A study of neurocysticercosis (NCC) was conducted in Ecuador in a group of 123 subjects (49 males and 74 females, 9-62 years of age) from a community sample that was part of a larger neuroepidemiological inquiry. A discriminant function procedure was used to select the tests that would be most sensitive at distinguishing between affected and nonaffected individuals. The results suggest that behavioural functions that include aspects of inhibitory control, motor and visual-motor output are impaired in adolescent and adult subjects with NCC.
KW  - brain
KW  - clinical aspects
KW  - diagnosis
KW  - helminths
KW  - human diseases
KW  - metacestodes
KW  - neurocysticercosis
KW  - parasites
KW  - Ecuador
KW  - South America
KW  - man
KW  - Taenia solium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - cerebrum
KW  - clinical picture
KW  - host behaviour
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) occur in chicken but are dependent on the cooking method.
AU  - Sinha, R.
AU  - Rothman, N.
AU  - Brown, E. D.
AU  - Salmon, C. P.
AU  - Knize, M. G.
AU  - Swanson, C. A.
AU  - Rossi, S. C.
AU  - Mark, S. D.
AU  - Levander, O. A.
AU  - Felton, J. S.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1995///
VL  - 55
IS  - 20
SP  - 4516
EP  - 4519
SN  - 0008-5472
AD  - Sinha, R.: Epidemiology and Biostatistics Programme, National Cancer Institute, N1H, Rockville Maryland 20892, USA.
N1  - Accession Number: 19951414417.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - Heterocyclic aromatic amines (HAAs) are mutagenic and carcinogenic compounds found in meats cooked at high temperatures. Although chicken is consumed in large quantities in the USA, there is little information on its HAA content. The objective of this study was to estimate the 5 predominant HAAa (IQ, MelQ, MeIQx, DiMeIQx and PhIP) in chicken cooked by various methods to different degrees of "doneness". Chicken breasts were pan fried, oven-broiled or grilled/barbecued. Whole chickens were roasted or stewed. Skinless, boneless chicken breasts were cooked to 3 degrees of doneness: just until done, well done or very well done. high levels of PhIP (ranging from 12 to 480 ng/g cooked meat) were found in chicken breasts when pan fried, oven-broiled and grilled/barbecued but not in whole roasted or stewed chicken. PhIP concentration increased in skinless, boneless chicken breast with longer cooking time, higher temperature and greater degree of surface browning. PhIP concentration was also high in chicken breasts cooked with skin and bones. MeIQx and DiMeIQx levels increased with the degree of doneness, whereas IQ and MeIQ were not detectable in any of these chicken samples. Certain cooking methods produce PhIP, a known colon and breast carcinogen in rodents and possibly a human carcinogen, at substantially higher levels in chicken than has been reported previously in red meat.
KW  - carcinogens
KW  - chicken meat
KW  - cooking
KW  - poultry
KW  - fowls
KW  - Gallus gallus
KW  - Gallus
KW  - Phasianidae
KW  - Galliformes
KW  - birds
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chickens
KW  - domesticated birds
KW  - Food Contamination, Residues and Toxicology (QQ200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414417&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol and pancreatic cancer in blacks and whites in the United States.
AU  - Silverman, D. T.
AU  - Brown, L. M.
AU  - Hoover, R. N.
AU  - Schiffman, M.
AU  - Lillemoe, K. D.
AU  - Schoenberg, J. B.
AU  - Swanson, G. M.
AU  - Hayes, R. B.
AU  - Greenberg, R. S.
AU  - Benichou, J.
AU  - Schwartz, A. G.
AU  - Liff, L. M.
AU  - Pottern, L. M.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1995///
VL  - 55
IS  - 21
SP  - 4899
EP  - 4905
SN  - 0008-5472
AD  - Silverman, D. T.: Epidemiology & Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951414940.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Human Nutrition
N2  - A population-based, case-control study of pancreatic cancer based on direct interviews with 307 white and 179 black incident cases and 1164 white and 945 black population controls was conducted in 3 areas of the USA to examine the role alcohol drinking plays as a risk factor for pancreatic cancer and to estimate the extent to which it may explain the higher incidence of pancreatic cancer in blacks compared to whites. The findings indicate that alcohol drinking at the levels typically consumed by the general population of the USA is probably not a risk factor for pancreatic cancer. The data suggest, however, that heavy alcohol drinking may be related to pancreatic cancer risk. Among men, blacks and whites who drank at least 57 drinks/week had odds ratios (ORs) of 2.2 (95% confidence interval (CI) = 0.9-5.6) and 1.4 (95% CI = 0.6-3.2), respectively. Among women, blacks who drank 8 to &lt;21 drinks/week had an OR of 1.8 (95% CI = 0.8-4.0) and those who drank at least 21 drinks/week had an OR of 2.5 (95% CI = 1.02-5.9), but whites with the same levels of alcohol intake experienced no increased risk. Compared to whites, blacks had higher ORs associated with heavy alcohol drinking (≥57 drinks/week) in men (P=0.04) and with moderate-to-heavy drinking (≥8 drinks/week) in women (P=0.03).
KW  - alcoholic beverages
KW  - neoplasms
KW  - pancreas
KW  - risk
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414940&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate.
AU  - Lucia, M. S.
AU  - Anzano, M. A.
AU  - Slayter, M. V.
AU  - Anver, M. R.
AU  - Green, D. M.
AU  - Shrader, M. W.
AU  - Logsdon, D. L.
AU  - Driver, C. L.
AU  - Brown, C. C.
AU  - Peer, C. W.
AU  - Roberts, A. B.
AU  - Sporn, M. B.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1995///
VL  - 55
IS  - 23
SP  - 5621
EP  - 5627
SN  - 0008-5472
AD  - Lucia, M. S.: Laboratory of Chemoprevention and Biometry Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19961402625.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 1406-16-2.  Subject Subsets: Human Nutrition
N2  - The ability of dietary N-(4-hydroxyphenyl)retinamide; 1α,25-dihydroxy-16-ene-23-yne-26,27-hexafluorochlolecalciferol (Ro24-5531) and tamoxifen to inhibit the development of androgen-promoted carcinomas of the accessory sex organs of male Lobund-Wistar rats was investigated. Invasive carcinomas of the seminal vesicle (SV) and anterior prostate (AP) were induced in Lobund-Wistar rats with 3 combinations of initiator (N-nitroso-N-methylurea (NMU)) and promoter (testosterone propionate (TP)): high-dose NMU (30 mg/kg + high-dose TP (20 mg via implant every 2 months)); high-dose NMU + low-dose TP (10 mg implanted every 2 months); or low-dose NMU (15 mg/kg) + low-dose TP. During the period of TP administration, rats were fed on a diet supplemented with N-(4-hydroxyphenyl)retinamide (1 or 2 nmol/kg diet), Ro24-5531 (1.25 or 2.5 nmol/kg diet), tamoxifen (0.5 or 5 mg/kg diet) or vehicle alone. After killing at 8.5 or 11 months, the prostate-seminal vesicle complex from each rat was processed in toto and histologically staged as to the extent of tumour involvement. In rats given low-dose TP, all 3 agents were significantly effective at reducing the incidence of invasive carcinomas of the SV and, to a lesser degree, the AP. Of the 3 agents, tamoxifen given in high dose (5 mg/kg) had the strongest activity, reducing the occurrence of invasive SV carcinomas from 72-83% in controls to 6% (P=0.0001) and the occurrence of invasive AP carcinomas from 50-72% to 18-22% (P&lt;0.05).
KW  - analogues
KW  - antineoplastic agents
KW  - vitamin D
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - cytotoxic agents
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A novel phorbol ester from Excoecaria agallocha.
AU  - Erickson, K. L.
AU  - Beutler, J. A.
AU  - Cardellina, J. H., II
AU  - McMahon, J. B.
AU  - Newman, D. J.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1995///
VL  - 58
IS  - 5
SP  - 769
EP  - 772
SN  - 0163-3864
AD  - Erickson, K. L.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, NCI-FCRDC, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19950313448.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - The leaves and latex of E. agallocha are used as a source of dart-arrow and/or fish poison, and are also used in herbal formulations. In Pakistan, the latex is used as an abortifacient, and to treat rheumatism, leprosy and paralysis. A novel phorbol ester, 12-deoxyphorbol 13-(3E,5E-decadienoate), was isolated from the bark, leaves and stems of E. agallocha (collected from northwest Australia). Its structure was determined by spectral means. 12-Deoxyphorbol 13-(3E,5E-decadienoate) inhibited the replication of HIV-1 [human immunodeficiency virus type 1] in vitro (IC50 value of 6 nM). The phorbol ester was also a potent displacer of [³H]-phorbol dibutyrate from rat brain membranes (IC50 of 17 nM).
KW  - antiviral properties
KW  - bark
KW  - brain
KW  - chemical structure
KW  - diterpenoids
KW  - esters
KW  - foliage
KW  - forest trees
KW  - human immunodeficiency viruses
KW  - leaves
KW  - mangroves
KW  - medicinal plants
KW  - medicinal properties
KW  - membranes
KW  - pharmacology
KW  - plant composition
KW  - poisonous plants
KW  - stems
KW  - trees
KW  - woody plants
KW  - Australia
KW  - animals
KW  - Euphorbiaceae
KW  - Excoecaria agallocha
KW  - plants
KW  - rats
KW  - eukaryotes
KW  - Euphorbiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Excoecaria
KW  - Euphorbiaceae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - anti-viral properties
KW  - cerebrum
KW  - chemical constituents of plants
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - toxic plants
KW  - Plant Composition (FF040) 
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Silviculture and Forest Management (KK110) 
KW  - Non-wood Forest Products (KK540) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950313448&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The pseudocalanolides: structure revision of calanolides C and D.
AU  - McKee, T. C.
AU  - Cardellina, J. H., II
AU  - Dreyer, G. B.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1995///
VL  - 58
IS  - 6
SP  - 916
EP  - 920
SN  - 0163-3864
AD  - McKee, T. C.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19950614177.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Registry Number: 9068-38-6.  Subject Subsets: Horticultural Science; Forestry; Forest Products; Aromatic & Medicinal Plants
N2  - Calanolides, coumarin compounds in a novel class of HIV-1 reverse transcriptase inhibitors, were isolated recently from a tropical rain forest tree, Calophyllum lanigerum var. austrocoriaceum. NMR spectra of synthetic structures corresponding to those initially reported for natural compounds calanolide C and calanolide D showed some subtle differences from those of the natural products. Further analysis has resulted in revision of the structures of the natural compounds, now renamed pseudocalanolides C and D.
KW  - chemical structure
KW  - coumarins
KW  - enzyme inhibitors
KW  - forest trees
KW  - forests
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - medicinal properties
KW  - plant composition
KW  - rain forests
KW  - reverse transcriptase
KW  - trees
KW  - woody plants
KW  - Calophyllum
KW  - Clusiaceae
KW  - plants
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Calophyllum
KW  - Calophyllum lanigerum
KW  - chemical constituents of plants
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - pseudocalanolides
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
KW  - Non-wood Forest Products (KK540) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950614177&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A reinvestigation of Maprounea triterpenes.
AU  - Beutler, J. A.
AU  - Kashman, Y.
AU  - Tischler, M.
AU  - Cardellina, J. H., II
AU  - Gray, G. N.
AU  - Currens, M. J.
AU  - Wall, M. E.
AU  - Wani, M. C.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1995///
VL  - 58
IS  - 7
SP  - 1039
EP  - 1046
SN  - 0163-3864
AD  - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19950315464.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in M. africana (collected from Central African Republic) and M. membranacea (collected from Cameroon) were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were isolated, 2 from M. africana and 3 from M. membranacea. Their structures were elucidated from spectral data.
KW  - chemical structure
KW  - medicinal plants
KW  - medicinal properties
KW  - plant composition
KW  - triterpenoids
KW  - Cameroon
KW  - Central African Republic
KW  - Euphorbiaceae
KW  - Euphorbiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Euphorbiaceae
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - chemical constituents of plants
KW  - drug plants
KW  - Maprounea
KW  - Maprounea africana
KW  - Maprounea membranacea
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950315464&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula.
AU  - Erickson, K. L.
AU  - Beutler, J. A.
AU  - Gray, G. N.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1995///
VL  - 58
IS  - 12
SP  - 1848
EP  - 1860
SN  - 0163-3864
AD  - Erickson, K. L.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19960305290.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Seven new sesquiterpenes, majapolenes A and B, majapolone and majapols A-D, were isolated from a Philippine collection of L. majuscula. With the exception of majapolene B, all compounds were isolated as inseparable diastereomeric mixtures. Their structures were elucidated from spectral data. Majapolene A, a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of L. caraibica.
KW  - chemical structure
KW  - cytotoxicity
KW  - plant composition
KW  - sesquiterpenes
KW  - sesquiterpenoids
KW  - Philippines
KW  - algae
KW  - Ceramiales
KW  - Rhodomelaceae
KW  - Rhodophyta
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - eukaryotes
KW  - algae
KW  - seaweeds
KW  - Rhodophyta
KW  - Ceramiales
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - chemical constituents of plants
KW  - Laurencia
KW  - Laurencia caraibica
KW  - Laurencia majuscula
KW  - red algae
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960305290&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of nitric oxide in parasitic infections.
AU  - James, S. L.
JO  - Microbiological Reviews
JF  - Microbiological Reviews
Y1  - 1995///
VL  - 59
IS  - 4
SP  - 533
EP  - 547
SN  - 0146-0749
AD  - James, S. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950811311.  Publication Type: Journal Article.  Language: English.  Number of References: 204 ref. Registry Number: 10102-43-9.  Subject Subsets: Helminthology; Protozoology
N2  - This review covers: nitric oxide synthesis; nitric oxide action; regulation of NO production (cytokine signals enhancing NO production, signals down-regulating NO production); antiparasitic effects of NO (macrophage activity against parasite targets- schistosomiasis, leishmaniasis, toxoplasmosis, and trypanosomiasis, the unresolved case of human macrophages, activity of other cell types against parasite targets- endothelial cells, and hepatocytes); immune evasion mechanisms against NO (Toxoplasma stage conversion, schistosome metabolic transitions); other effects of NO in parasitic diseases (immunosuppression, vascular function, cancer, cerebral malaria).
KW  - helminths
KW  - nitric oxide
KW  - parasites
KW  - reviews
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Smoking and cancer mortality among US veterans: a 26-year follow-up.
AU  - McLaughlin, J. K.
AU  - Hrubec, Z.
AU  - Blot, W. J.
AU  - Fraumeni, J. F., Jr.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1995///
VL  - 60
IS  - 2
SP  - 190
EP  - 193
SN  - 0020-7136
AD  - McLaughlin, J. K.: National Cancer Institute, 6130 Executive Blvd, Room 543, Rockville, MD 20852, USA.
N1  - Accession Number: 19962001424.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Public Health
N2  - A 26-year follow-up of 248 046 veterans in the USA evaluating the risks of cigarette smoking revealed strong dose response effects between smoking and total cancer and a large number of cancer sites. Over 50% of cancer deaths among current smokers and 23% of cancer deaths among former smokers were attributable to cigarette smoking.
KW  - mortality
KW  - neoplasms
KW  - risk factors
KW  - tobacco smoking
KW  - toxicology
KW  - veterans
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - death rate
KW  - United States of America
KW  - war veterans
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prostate cancer risk in US blacks and whites with a family history of cancer.
AU  - Hayes, R. B.
AU  - Liff, J. M.
AU  - Pottern, L. M.
AU  - Greenberg, R. S.
AU  - Schoenberg, J. B.
AU  - Schwartz, A. G.
AU  - Swanson, G. M.
AU  - Silverman, D. T.
AU  - Morris Brown, L.
AU  - Hoover, R. N.
AU  - Fraumeni, J. F., Jr.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1995///
VL  - 60
IS  - 3
SP  - 361
EP  - 364
SN  - 0020-7136
AD  - Hayes, R. B.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001421.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Public Health
N2  - Prostate cancer occurs more frequently in blacks than whites in the USA. A population-based case-control study which investigated the association with family history of cancer was carried out among 981 men (479 black, 502 white) with pathologically confirmed prostate cancer, diagnosed between August 1, 1986, and April 30, 1989, and 1315 controls (594 black, 721 white). Study subjects, aged 40-79, resided in Atlanta (Georgia), Detroit (Michigan), and 10 counties in New Jersey. Prostate cancer risk was significantly elevated among those who reported a history of prostate cancer in first-degree relatives (OR = 3.2; 95% CI: 2.0-5.0), with blacks and whites having similarly elevated risks. These risks were unchanged by statistical adjustment for job-related socio-economic status, education, income and marital status. Overall, the ORs associated with history of prostate cancer in fathers and brothers were 2.5 (95% CI: 1.5-4.2) and 5.3 (95% CI: 2.3-12.5), respectively. Younger and older subjects showed consistently elevated risks associated with a family history of prostate cancer. Only small non-significant excesses of prostate cancer risk were associated with a family history of breast, colorectal, or other cancer. While familial occurrence is a key risk factor for prostate cancer and likely to be genetically based, the similar familial risks among blacks and whites suggest that the ethnic disparity in incidence is influenced by environmental factors.
KW  - blacks
KW  - epidemiology
KW  - ethnic groups
KW  - familial incidence
KW  - human diseases
KW  - neoplasms
KW  - prostate
KW  - prostate cancer
KW  - risk factors
KW  - Georgia
KW  - Michigan
KW  - New Jersey
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southeastern States of USA
KW  - East North Central States of USA
KW  - North Central States of USA
KW  - Lake States of USA
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001421&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica.
AU  - Strickler, H. D.
AU  - Rattray, C.
AU  - Escoffery, C.
AU  - Manns, A.
AU  - Schiffman, M. H.
AU  - Brown, C.
AU  - Cranston, B.
AU  - Hanchard, B.
AU  - Palefsky, J. M.
AU  - Blattner, W. A.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1995///
VL  - 61
IS  - 1
SP  - 23
EP  - 26
SN  - 0020-7136
AD  - Strickler, H. D.: Viral and Environmental Epidemiology Branches, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962002660.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
KW  - biopsy
KW  - cervical cancer
KW  - concurrent infections
KW  - HTLV infections
KW  - human diseases
KW  - neoplasms
KW  - polymerase chain reaction
KW  - risk factors
KW  - sexual behaviour
KW  - women
KW  - Jamaica
KW  - Deltaretrovirus
KW  - human papillomaviruses
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - Papillomaviridae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - cancers
KW  - colposcopy
KW  - HTLV-BLV group
KW  - human papillomavirus
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Pap smear
KW  - Papovaviridae
KW  - PCR
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Undernutrition among Bedouin Arab children: a follow-up of the Bedouin Infant Feeding Study.
AU  - Forman, M. R.
AU  - Hundt, G. L.
AU  - Berendes, H. W.
AU  - Abu-Saad, K.
AU  - Zangwill, L.
AU  - Chang, D.
AU  - Bellmaker, I.
AU  - Abu-Saad, I.
AU  - Graubard, B. I.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 61
IS  - 3
SP  - 495
EP  - 500
SN  - 0002-9165
AD  - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19951404448.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Human Nutrition
N2  - After 10 years of urban settlement, 680 Bedouin Arab children in Israel, who had had anthropometric assessment from birth (1981-1982) through early childhood, were reassessed in 1991-1992 to compare the rates of stunting in early and later childhood as well as to describe the factors influencing current height-for-age. Stunting had decreased from 32.7% at 18 months to 7.2% at 10 years in the 1981 birth cohort and decreased from 17.5% at 9 months to 8.2% at 9 years in the 1982 birth cohort. Based on a multiple-linear-regression analysis, height in early childhood and maternal height were significantly and positively associated with current mean height-for-age in both cohorts. In the 1982 cohort, socioeconomic status in early childhood was positively and significantly associated with current mean height-for-age. Thus, conditions that were present in early childhood had the largest influence on current height. In 1992, 10 and 6% of the infant siblings of the 1981 and 1982 cohorts, respectively, were stunted cohorts. Therefore, the high rates of early childhood stunting in 1981-1982 appeared to be a birth cohort-specific phenomenon.
KW  - children
KW  - ethnic groups
KW  - growth
KW  - growth retardation
KW  - infant feeding
KW  - infants
KW  - nutritional state
KW  - social change
KW  - undernutrition
KW  - Israel
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - West Asia
KW  - Asia
KW  - nutritional status
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404448&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Thermic effect of food in humans: methods and results from use of a respiratory chamber.
AU  - Tataranni, P. A.
AU  - Larson, D. E.
AU  - Snitker, S.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 61
IS  - 5
SP  - 1013
EP  - 1019
SN  - 0002-9165
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19951406877.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - During the past 2 decades, many investigators have estimated the thermic effect of food (TEF) in man and have speculated on its role in the development of obesity. Ways of computing TEF from daily energy expenditure estimations in a respiratory chamber were compared, the determinants of TEF evaluated and the relation between TEF and change in body weight was investigated. In 471 subjects, TEF was 1697±857 kJ/d (χ±s.d.), i.e., 18±9% of energy intake. In 114 subjects studied more than once, intraindividual TEF variability was very high (CV=48%). TEF correlated positively with the level of spontaneous physical activity (SPA) and negatively with fasting plasma glucose and insulin concentrations. TEF corelated inversely with age (men only) and body weight, percent body fat and waist-to-hip ratio (women only). The level of SPA and fasting plasma glucose concentration were the only significant determinants of TEF, explaining 15% of its variance. In 137 subjects in whom body weight was estimated ≥ 6 months after TEF estimation (mean follow-up duration of 2.9±1.7 years) a low TEF was not predictive of body weight gain. It is concluded that, despite the low reproducibility of TEF from use of a respiratory chamber, data in a large number of subjects is increased by higher SPAs and that insulin resistance is associated with a low TEF. More important, longitudinal data indicate that the variability in TEF is not associated with changes in body weight.
KW  - food intake
KW  - heat production
KW  - men
KW  - methodology
KW  - obesity
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorigenesis
KW  - fatness
KW  - methods
KW  - thermogenesis
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary behavior change: the challenge of recasting the role of fruit and vegetables in the American diet.
AU  - Heimendinger, J.
AU  - Duyn, M. A. S. van
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 61
IS  - 6(S)
SP  - 1397S
EP  - 1401S
SN  - 0002-9165
AD  - Heimendinger, J.: National Cancer Institute, National Institutes of Health, Division of Cancer Prevention and Control, 9000 Rockville Pike, EPN 330, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951408559.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - Trends in intake of fruits and vegetables in the USA are examined using a combination of consumption and marketing data. A brief overview of the current social marketing programme, 5 a Day for Better Health is also provided. It is described how theories of behaviour change have been applied to the development of this programme. Finally, using the Mediterranean diet as a model system, a new strategy for using the sensory qualities of fruit and vegetables, in combination with a health message, to help encourage Americans to increase consumption of these foods is proposed.
KW  - behaviour
KW  - diet studies
KW  - feeding behaviour
KW  - fruit
KW  - intake
KW  - nutrition education
KW  - nutrition programmes
KW  - vegetables
KW  - Mediterranean region
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - behavior
KW  - feeding behavior
KW  - feeding programmes
KW  - feeding programs
KW  - food programs
KW  - Mediterranean countries
KW  - nutrition programs
KW  - United States of America
KW  - vegetable crops
KW  - Human Nutrition (General) (VV100) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408559&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analgesics and cancers of the renal pelvis and ureter.
AU  - Linet, M. S.
AU  - Chow WongHo
AU  - McLaughlin, J. K.
AU  - Wacholder, S.
AU  - Yu, M. C.
AU  - Schoenberg, J. B.
AU  - Lynch, C.
AU  - Fraumeni, J. F., Jr.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1995///
VL  - 62
IS  - 1
SP  - 15
EP  - 18
SN  - 0020-7136
AD  - Linet, M. S.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962005038.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Public Health
N2  - To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the USA (New Jersey, Iowa, California). Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the non-prescription and prescription analgesics evaluated or among regular users of phenacetin, acetaminophen or aspirin. Neither cumulative lifetime ingestion nor duration of regular use of these 3 drugs, whether alone or in combination, was associated with significantly increased risk of RPU cancer, although a slight excess was observed among long-term users of acetaminophen. Risk was not increased among persons reporting highest cumulative dose and/or longest duration of phenacetin use. Although this study of RPU cancer is the largest to date, it was nonetheless limited by the small number of regular analgesic users and the relatively low response rates. Because of the relatively recent onset of widespread use of acetaminophen, its pharmacological similarity to phenacetin, a known urothelial carcinogen, and the elevation in risk seen in long-term users, further surveillance of this analgesic is believed to be warranted.
KW  - analgesics
KW  - human diseases
KW  - kidneys
KW  - neoplasms
KW  - risk factors
KW  - ureter
KW  - urinary tract
KW  - California
KW  - Iowa
KW  - New Jersey
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - West North Central States of USA
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - cancer sites
KW  - cancers
KW  - pain killers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of alcohol consumption on plasma carotenoid concentrations in premenopausal women: a controlled dietary study.
AU  - Forman, M. R.
AU  - Beecher, G. R.
AU  - Lanza, E.
AU  - Reichman, M. E.
AU  - Graubard, B. I.
AU  - Campbell, W. S.
AU  - Marr, T.
AU  - Yong, L. C.
AU  - Judd, J. T.
AU  - Taylor, P. R.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 1
SP  - 131
EP  - 135
SN  - 0002-9165
AD  - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19951409555.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - This 6-month controlled dietary study compared the effect of alcohol 30 g/day for 3 menstrual cycles with 3 alcohol-free cycles on plasma carotenoid concentrations in 18 nonsmoking, premenopausal women (21 to 39 years old). Participants were randomly allocated within a crossover design to either phase and consumed total carotenoids about 6 mg/day under isoenergetic conditions. Blood was drawn during the third menstrual cycle of each alcohol phase. After adjustment for the mean daily specific carotenoid and energy intakes for each alcohol phase, the paired differences in mean plasma α- and β-carotene concentrations were higher by 19% (P=0.027) and 13% (P=0.034), respectively, during the alcohol-intake phase of the study. The paired difference in mean plasma lutein/zeaxanthin concentration was lower by 17% (P=0.031) when the participants consumed alcohol than when they did not. This is the first reported study in women to document the independent effect of alcohol on plasma carotenoid concentrations without the potential interaction of smoking under controlled dietary conditions.
KW  - alcoholic beverages
KW  - blood
KW  - carotenoids
KW  - intake
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - tetraterpenoids
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoic acid and methotrexate specifically increase PHA-E lectin binding to a 67-kDa glycoprotein in LA-N-1 human neuroblastoma cells.
AU  - Ross, S. A.
AU  - Jones, C. S.
AU  - Luca, L. M. de
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1995///
VL  - 62
IS  - 3
SP  - 303
EP  - 308
SN  - 0020-7136
AD  - Ross, S. A.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bldg. 37, Rm. 3A17 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19961404454.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 59-05-2, 302-79-4.  Subject Subsets: Human Nutrition
N2  - Retinoic acid (RA) decreased growth and increased morphologic differentiation of human neuroblastoma LA-N-1 cells. These phenomena correlated with a specific enhancement of PHA-E lectin binding to a 67-kDa glycoprotein (gp67). Gp67 was susceptible to N-glycanase and displayed bovine serum albumin (BSA) binding by affinity chromatography analysis. The chemotherapeutic agent methotrexate (MTX) also reduced growth and induced differentiation of LA-N-1 cells. In addition, the cells responded to MTX as well as to doxorubicin by a marked increase in PHA-E binding to gp67. It is concluded that reduced growth and induction of morphological differentiation of LA-N-1 cells correlated with increased binding of PHA-E to gp67.
KW  - binding
KW  - cell cultures
KW  - cell growth
KW  - cell membranes
KW  - glycoproteins
KW  - lectins
KW  - methotrexate
KW  - neoplasms
KW  - receptors
KW  - retinoic acid
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - amethopterin
KW  - cancers
KW  - cell elongation
KW  - tretinoin
KW  - vitamin A acid
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404454&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cinnamic acid: a natural product with potential use in cancer intervention.
AU  - Liu Lei
AU  - Hudgins, W. R.
AU  - Shack, S.
AU  - Yin MuQuan
AU  - Samid, D.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1995///
VL  - 62
IS  - 3
SP  - 345
EP  - 350
SN  - 0020-7136
AD  - Liu Lei: Clinical Pharmacology Branch, Division of Cancer Treatment, National Cancer Institute, Building 10, Room 12C103, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960305465.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 621-82-9.  Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Human Nutrition
N2  - Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, has a long history of human use as a component of plant-derived scents and flavourings. In this study, cinnamic acid was shown to induce cytostasis and a reversal of malignant properties of human tumour cells in vitro. The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. Using melanoma cells as a model, cinnamic acid was found to induce cell differentiation, as evidenced by morphological changes and increased melanin production. Moreover, treated cells had reduced invasive capacity associated with modulation of expression of genes implicated in tumour metastasis (collagenase type IV, and tissue inhibitor metalloproteinase 2) and immunogenicity (HLA-A3, class-1 major histocompatibility antigen). Further molecular analysis indicated that the anti-tumour activity of cinnamic acid may be due in part to the inhibition of protein isoprenylation known to block mitogenic signal transduction. The results presented here identify cinnamic acid as a new member of the aromatic fatty acid class of differentiation-inducers with potential use in cancer intervention.
KW  - antineoplastic properties
KW  - cell differentiation
KW  - cell lines
KW  - cinnamic acid
KW  - fatty acids
KW  - gene expression
KW  - in vitro
KW  - metastasis
KW  - modulation
KW  - natural products
KW  - neoplasms
KW  - phenylpropanoids
KW  - plant composition
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anti-neoplastic properties
KW  - cancers
KW  - chemical constituents of plants
KW  - cytodifferentiation
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960305465&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of dual-energy X-ray absorptiometry in obese individuals.
AU  - Tataranni, P. A.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 4
SP  - 730
EP  - 734
SN  - 0002-9165
AD  - Tataranni, P. A.: Department of Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19951413477.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Human Nutrition
N2  - Body composition of 183 obese subjects with a wide range of body sizes (body mass index = 17.7-52.5 kg/m²) was assessed using dual-energy X-ray absorptiometry (DXA). Results from both sides of the body were compared to test the hypothesis that body composition is symmetrical. Data obtained by DXA were compared with those obtained by hydrodensitometry. Also the hypothesis that body composition of 1 side of the body (by DXA) accurately predicts whole body composition (by hydrodensitometry) was investigated. This latter hypothesis was validated.
KW  - body composition
KW  - estimation
KW  - methodology
KW  - obesity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - methods
KW  - Human Nutrition (General) (VV100) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413477&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy metabolism in weight-stable postobese individuals.
AU  - Larson, D. E.
AU  - Ferraro, R. T.
AU  - Robertson, D. S.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 4
SP  - 735
EP  - 739
SN  - 0002-9165
AD  - Larson, D. E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19951413498.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - A low metabolic rate for a given body size and body composition and a low ratio of fat to carbohydrate oxidation predict body weight gain. Such metabolic traits could also explain, in part, the propensity of previously obese (post-obese) individuals to regain weight after dieting. 11 post-obese adults 43±13 years old, weighing 80.6±10.2 kg with 30±7% body fat (mean±s.d.); who lost 57±38 kg (23-139 kg) over 14±12 months (6-48 months) on various diet programmes and had maintained this weight loss for ≥ 2 months (2-72 months; 21±27 months), were studied. After ≥ 2 days of a weight-maintenance diet in a metabolic ward, 24-h energy expenditure and ratio of fat to carbohydrate oxidation were estimated in a respiratory chamber. Compared with a control group (n=110) with similar physical characteristics (43±14 years old, weighing 79.5±11.4 kg with 30±12% body fat), post-obese individuals had similar energy expenditures adjusted for fat-free mass, fat mass, age and sex, but higher respiratory quotients over 24 h (0.883±0.026 compared with 0.863±0.024, P&lt;0.01) and during sleep, 10 h after the last meal (0.894±0.063 compared with 0.845±0.055). Results suggest that post-obese individuals have low rates of fat oxidation that may explain their propensity to regain weight. Therefore, obesity treatment and/or prevention should be aimed at reducing dietary fat and increasing fat oxidation (possibly by exercise) to prevent increases in body fat stores.
KW  - adults
KW  - body weight
KW  - energy
KW  - energy metabolism
KW  - obesity
KW  - weight reduction
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol and energy intake.
AU  - Lands, W. E. M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 5 SUPP
SP  - 1101S
EP  - 1106S
SN  - 0002-9165
AD  - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, Willco Building, Suite 402, 6000 Executive Boulevard, MSC 7003, Bethesda, MD 20892-7003, USA.
N1  - Accession Number: 19951414602.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 55 ref. Registry Number: 64-17-5.  Subject Subsets: Human Nutrition
KW  - alcoholic beverages
KW  - energy
KW  - energy intake
KW  - ethanol
KW  - intake
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Advances in human energy metabolism: balancing energy requirements and energy intake
KW  - ethyl alcohol
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Determination of optimal vitamin C requirements in humans.
AU  - Levine, M.
AU  - Dhariwal, K. R.
AU  - Welch, R. W.
AU  - Wang, Y. H.
AU  - Park, J. B.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 6 (SUP)
SP  - 1347S
EP  - 1356S
SN  - 0002-9165
AD  - Levine, M.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-0850, USA.
N1  - Accession Number: 19961400398.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 137 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
KW  - ascorbic acid
KW  - nutrient requirements
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Antioxidant vitamins and beta-carotene in disease prevention
KW  - dietary standards
KW  - food requirements
KW  - nutritional requirements
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of nutrition intervention on intermediate endpoints in esophageal and gastric carcinogenesis.
AU  - Taylor, P. R.
AU  - Wang GuoQing
AU  - Dawsey, S. M.
AU  - Guo, W.
AU  - Mark, S. D.
AU  - Li JunYao
AU  - Blot, W. J.
AU  - Li Bing
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 6 (SUP)
SP  - 1420S
EP  - 1423S
SN  - 0002-9165
AD  - Taylor, P. R.: National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20896, USA.
N1  - Accession Number: 19961400409.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 9 ref. Subject Subsets: Human Nutrition
KW  - carcinogenesis
KW  - minerals
KW  - oesophagus
KW  - stomach
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Antioxidant vitamins and beta-carotene in disease prevention
KW  - esophagus
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400409&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of α-tocopherol and β-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention study.
AU  - Albanes, D.
AU  - Heinonen, O. P.
AU  - Huttunen, J. K.
AU  - Taylor, P. R.
AU  - Virtamo, J.
AU  - Edwards, B. K.
AU  - Haapakoski, J.
AU  - Rautalahti, M.
AU  - Hartman, A. M.
AU  - Palmgren, J.
AU  - Greenwald, P.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1995///
VL  - 62
IS  - 6 (SUP)
SP  - 1427S
EP  - 1430S
SN  - 0002-9165
AD  - Albanes, D.: National Cancer Institute, 6130 Executive Plaza North, MSC 7326 Room 211, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19961400411.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 28 ref. Registry Number: 59-02-9, 7235-40-7.  Subject Subsets: Human Nutrition
KW  - alpha-tocopherol
KW  - antioxidants
KW  - beta-carotene
KW  - neoplasms
KW  - prevention
KW  - supplements
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Antioxidant vitamins and beta-carotene in disease prevention
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400411&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Suppressive effect of interleukin-4 neutralization differs for granulomas around Schistosoma mansoni eggs injected into mice compared with those around eggs laid in infected mice.
AU  - Eltoum, I. A.
AU  - Wynn, T. A.
AU  - Poindexter, R. W.
AU  - Finkelman, F. D.
AU  - Lewis, F. A.
AU  - Sher, A.
AU  - Cheever, A. W.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1995///
VL  - 63
IS  - 7
SP  - 2532
EP  - 2536
SN  - 0019-9567
AD  - Eltoum, I. A.: Section on Host-Parasite Relations, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20890, USA.
N1  - Accession Number: 19960803635.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 207137-56-2.  Subject Subsets: Helminthology
N2  - A number of anticytokine antibody treatments have been shown to have a remarkable effect in modulating granulomas around intravenously injected Schistosoma mansoni eggs in the mouse model but little effect on the size of hepatic granulomas around eggs laid during experimental infections in mice. To examine this discrepancy, the effects of anticytokine antibodies on liver and lung granulomas around injected eggs and around eggs laid during infection in both locations were investigated. Anti-interleukin (IL)-4 treatment by neutralizing MAb greatly reduced the volume of granulomas around eggs injected into the liver via the portal vein and around eggs injected into the lungs via the tail vein. In contrast, granulomas around eggs laid by worms in either the liver or the lungs during the course of infection were not significantly decreased by anti-IL-4 treatment. Thus, site is not important for the disparate effects of anti-IL-4 in granuloma formation around injected versus laid eggs. This effect was seen in naive and sensitized animals and is most probably due to differences in the quality of injected eggs versus those laid in situ.
KW  - disease models
KW  - experimental infections
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - immunology
KW  - immunopathology
KW  - interleukin 4
KW  - laboratory animals
KW  - liver
KW  - lungs
KW  - monoclonal antibodies
KW  - parasites
KW  - pathology
KW  - schistosomiasis
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi.
AU  - Stevenson, B.
AU  - Schwan, T. G.
AU  - Rosa, P. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1995///
VL  - 63
IS  - 11
SP  - 4535
EP  - 4539
SN  - 0019-9567
AD  - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19960503530.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Previous studies have demonstrated that B. burgdorferi in the midguts of infected ticks shows increased expression of the antigenic outer surface protein OspC after the ticks have ingested a blood meal. This differential expression is at least partly due to a change in temperature, as an increase in OspC levels is also observed when cultures are shifted from 23 to 35°C. Immunoblotting of bacterial lysates with sera from infected mice indicated that the levels of several additional antigens were also increased in bacterial cultures shifted to 35°C; one antigen was identified as OspE. The authors also observed differential expression of OspF, which has been proposed to be coexpressed in an operon with the gene encoding OspE.
KW  - antigens
KW  - gene expression
KW  - laboratory animals
KW  - Lyme disease
KW  - proteins
KW  - temperature
KW  - Borrelia burgdorferi
KW  - mice
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - bacterium
KW  - immunogens
KW  - lyme borreliosis
KW  - outer surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503530&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic map of eight microsatellite markers comprising two linkage groups on rat chromosome 6.
AU  - Du, Y.
AU  - Remmers, E. F.
AU  - Zha, H.
AU  - Goldmuntz, E. A.
AU  - Mathern, P.
AU  - Crofford, L. J.
AU  - Szpirer, J.
AU  - Szpirer, C.
AU  - Wilder, R. L.
JO  - Cytogenetics and Cell Genetics
JF  - Cytogenetics and Cell Genetics
Y1  - 1995///
VL  - 68
IS  - 1/2
SP  - 107
EP  - 111
SN  - 0301-0171
AD  - Du, Y.: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950100890.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9001-15-4, 9007-49-2, 9026-43-1.  Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2  - Five genes and 3 anonymous DNA loci were mapped to rat chromosome 6 by genetic linkage and somatic cell hybrid analyses. The 8 loci were all identified by PCR-based microsatellite polymorphism analysis and were characterized in 40 F2 intercross progeny of Fischer (F344/N) and Lewis (LEW/N) inbred rats for segregation analysis. These markers formed 2 linkage groups spanning 58.1 and 4.0 cM. The 1st linkage group is comprised of 2 anonymous DNA loci and 4 genes with the following map order and distances; D6Cep8 (previously D3)-17.9 cM-D6Arb309-2.5 cM-Vsnl1 (neural visinin-like protein)-20.4 cM-Prkar2b (type IIβ regulatory subunit of cAMP-dependent protein kinase)-8.8 cM-Fkhl1 (forkhead-like transcription factor BF-1)-8.5 cM-Rnulc(18-3A U1 RNA). The 2nd linkage group is comprised of 1 gene, Ckb (creatine kinase, brain) and 1 anonymous DNA locus, D6Arb54, separated by 4.0 cM. For each marker, 2 to 8 alleles were detected in a panel of 16 inbred rat strains (ACI/N, BN/SsN, BUF/N, DA/Bk1, F344/N, LER/N, LEW/N, LOU/MN, MNR/N, MR/N, SHR/N, SR/Jr, SS/Jr, WBB1/N, WBB2/N, and WKY/N). Comparative mapping information indicated that rat chromosome 6 exhibits syntenic conservation with mouse chromosome 12. Homologues of the rat chromosome 6 loci were identified on human chromosomes 2, 7 and 14.
KW  - biotechnology
KW  - brain
KW  - chromosomes
KW  - creatine kinase
KW  - DNA
KW  - gene mapping
KW  - linkage groups
KW  - markers
KW  - microsatellites
KW  - protein kinase
KW  - transcription factors
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - creatine phosphokinase
KW  - deoxyribonucleic acid
KW  - minisatellites
KW  - No. 6
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Laboratory Animal Science (LL040) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis.
AU  - Vaidya, A. B.
AU  - Muratova, O.
AU  - Guinet, F.
AU  - Keister, D.
AU  - Wellems, T. E.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1995///
VL  - 69
IS  - 1
SP  - 65
EP  - 71
SN  - 0166-6851
AD  - Vaidya, A. B.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19950805782.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - A Plasmodium falciparum clone, Dd2, differentiates into normal-appearing gametocytes, yet poorly infects mosquitoes. The Dd2 clone, however, effectively cross-fertilized HB3, a Central American P. falciparum clone, and yielded several independent recombinant progeny. 11 HB3 X Dd2 progeny were examined for their ability to infect mosquitoes (Anopheles freeborni) and to differentiate into male gametes. The analyses indicated that the poor mosquito-infectivity of the Dd2 clone results from a defect in male gametogenesis. This defect was inherited as a single locus in the independent recombinant progeny of HB3 X Dd2. Comparison with a restriction fragment length polymorphism map of the HB3 X Dd2 cross indicated that the defective phenotype of Dd2 maps to a locus on P. falciparum chromosome 12. This genetic locus may contain determinants that play a crucial role in male gametogenesis by P. falciparum.
KW  - chromosomes
KW  - Disease vectors
KW  - gametogenesis
KW  - genetics
KW  - human diseases
KW  - infectivity
KW  - parasites
KW  - Anopheles freeborni
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805782&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Unique insertion sequence and pattern of CD4 expression in variants selected with immunotoxins from human immunodeficiency virus type 1-infected T cells.
AU  - Fang, H.
AU  - Pincus, S. H.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 1
SP  - 75
EP  - 81
SN  - 0022-538X
AD  - Fang, H.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth St., Hamilton, MT 59840, USA.
N1  - Accession Number: 19952010306.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref.
KW  - cd4 antigens
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infectivity
KW  - mutants
KW  - T lymphocytes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - human immunodeficiency virus
KW  - immunotoxins
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010306&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An autoregulated dual-function antitat gene for human immunodeficiency virus type 1 gene therapy.
AU  - Lisziewicz, J.
AU  - Sun, D.
AU  - Trapnell, B.
AU  - Thomson, M.
AU  - Chang, H. K.
AU  - Ensoli, B.
AU  - Peng, B.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 1
SP  - 206
EP  - 212
SN  - 0022-538X
AD  - Lisziewicz, J.: Laboratory of Tumour Cell Biology, Bldg. 37, Rm. 6A09, National Cancer Institute, 37 Convent Dr. MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952010288.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
KW  - gene therapy
KW  - genetic regulation
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - tat gene
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010288&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rabies virus replication in primary murine bone macrophages and in human and murine macrophage-like cell lines: implications for viral persistence.
AU  - Ray, N. B.
AU  - Ewalt, L. C.
AU  - Lodmell, D. L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 2
SP  - 764
EP  - 772
SN  - 0022-538X
AD  - Ray, N. B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19952203306.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - To determine whether rabies viruses replicate in macrophage-like cells, several human and murine macrophage-like cell lines, and primary cultures of murine bone marrow macrophages, were incubated with the Evelyn-Rokitnicki-Abelseth (ERA) virus and several different street rabies viruses (SRV). ERA rabies virus replicated well in human monocytic U937 and THP-1 cells and murine macrophage IC-21 cells, and in primary cultures of murine macrophages. Very little replication was detected in murine monocytic WEHI-3BD- and PU5-1R cells and ERA virus did nor replicate in murine monocytic P388D1 or J774A.1 cells. A tissue culture-adapted SRV of bat origin also replicated in IC-21 and U937 cells. Non-tissue culture-adapted SRV isolated from different animal species, particularly bats, replicated very little in U937, THP-1, IC-21 cells and primary murine bone marrow macrophages. To determine whether rabies virus replication depends on the state of differentiation of the macrophage-like cells, human promyelocytic HL-60 were differentiated with 12-O-tetradeconylphorbol-13-acetate (TPA). ERA rabies virus replicated in the differentiated HL-60 but not in undifferentiated HL-60 cells. Persistent infections were established in macrophage-like U937 cells with ERA rabies virus and SRV, and infectious SRV was isolated from adherent bone marrow cells of mice that had been infected 96 days earlier. Virus harvest from persistently infected U937 and the adherent bone marrow cells had specifically adapted to each cell. This specificity was shown by the inability of the viruses to infect macrophages other than U937 and primary bone marrow macrophages, respectively. Virus titres of the persistently infected U937 cells fluctuated with extended cell passage. After 30 passages, virus released from the cells lost virulence as shown by its inability to kill intracranially infected mice. The avirulent virus released from the persistently infected cells was more efficient in infecting and replicating in naive U937 cells than the virus which was used to establish the persistent infection. These results suggest that macrophages may serve as reservoirs of infection in vivo, sequestering virus which may subsequently be activated from its persistent state, resulting in clinical infection and death.
KW  - cell culture
KW  - macrophages
KW  - strain differences
KW  - viral diseases
KW  - man
KW  - mice
KW  - rabies virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Lyssavirus
KW  - Rhabdoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - persistent infections
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Tissue and Cell Culture (LL700) 
KW  - Laboratory Animal Science (LL040) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952203306&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
AU  - Engelman, A.
AU  - Englund, G.
AU  - Orenstein, J. M.
AU  - Martin, M. A.
AU  - Craigie, R.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 5
SP  - 2729
EP  - 2736
SN  - 0022-538X
AD  - Engelman, A.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962000998.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
KW  - genomes
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - molecular biology
KW  - mutants
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000998&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus.
AU  - Arthur, L. O.
AU  - Bess, J. W. Jr
AU  - Urban, R. G.
AU  - Strominger, J. L.
AU  - Morton, W. R.
AU  - Mann, D. L.
AU  - Henderson, L. E.
AU  - Benveniste, R. E.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 5
SP  - 3117
EP  - 3124
SN  - 0022-538X
AD  - Arthur, L. O.: AIDS Vaccine Program, PRI/DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19962001016.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref.
KW  - animal models
KW  - genetics
KW  - immunization
KW  - infections
KW  - viral diseases
KW  - Macaca
KW  - monkeys
KW  - simian immunodeficiency virus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - immune sensitization
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.
AU  - Englund, G.
AU  - Theodore, T. S.
AU  - Freed, E. O.
AU  - Engelman, A.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 5
SP  - 3216
EP  - 3219
SN  - 0022-538X
AD  - Englund, G.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001005.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
KW  - genetics
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - macrophages
KW  - molecular biology
KW  - monocytes
KW  - polymerase chain reaction
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inducible and conditional inhibition of human immunodeficiency virus proviral expression by vascular stomatitis virus matrix protein.
AU  - Paik, S. Y.
AU  - Banerjea, C.
AU  - Harmison, G. G.
AU  - Chen, C. J.
AU  - Schubert, M.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 6
SP  - 3529
EP  - 3537
SN  - 0022-538X
AD  - Paik, S. Y.: Correspondence address: M. Schubert, Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bldg. 36, Rm. 5W21, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009353.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9007-49-2. 
KW  - acquired immune deficiency syndrome
KW  - cells
KW  - dna
KW  - gene expression
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - latent infections
KW  - molecular biology
KW  - pathogenesis
KW  - regulation
KW  - transcription
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - reactivation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009353&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.
AU  - Lusso, P.
AU  - Cocchi, F.
AU  - Balotta, C.
AU  - Markham, P. D.
AU  - Louie, A.
AU  - Farci, P.
AU  - Pal, R.
AU  - Gallo, R. C.
AU  - Reitz, M. S. Jr.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 6
SP  - 3712
EP  - 3720
SN  - 0022-538X
AD  - Lusso, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg 37, Rm. 6A09, 37 Convent Dr., Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952008733.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
KW  - cellular biology
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infectivity
KW  - macrophages
KW  - molecular biology
KW  - T lymphocytes
KW  - tropisms
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cell biology
KW  - cell tropism
KW  - human immunodeficiency virus
KW  - superinfections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008733&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence that flavivirus NS1-NS2A cleavage is mediated by a membrane-bound host protease in the endoplasmic reticulum.
AU  - Falgout, B.
AU  - Markoff, L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 11
SP  - 7232
EP  - 7243
SN  - 0022-538X
AD  - Falgout, B.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970500281.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Previous deletion mutagenesis studies have shown that the flavivirus NS1-NS2A cleavage requires the 8 C-terminal residues of NS1, constituting the cleavage recognition sequence, and sequences in NS2A far downstream of the cleavage site. The authors have now shown (using recombinant vaccinia viruses) that replacement of all of NS1 upstream of the cleavage recognition sequence with prM sequences still allows cleavage in vivo. Thus, other than the 8 C-terminal residues, NS1 is dispensable for NS1-NS2A cleavage. However, deletion of the N-terminal signal sequence abrogated cleavage, suggesting that entry into the exocytic pathway is required. Cleavage in vivo was not blocked by brefeldin A, and cleavage could occur in vitro in the presence of dog pancreas microsomes, indicating that NS1-NS2A cleavage occurs in the endoplasmic reticulum (ER). Four in-frame deletions in NS2A were cleavage defective in vitro, as were 2 mutants in which NS4A-NS4B sequences were substituted for NS2A, suggesting that most of NS2A is required. A series of substitution mutants were constructed in which all Asp, Cys, Glu, His and Ser residues in NS2A were collectively replaced; all standard proteases require at least one of these residues in their active sites. No single mutant was cleavage defective, suggesting that NS2A is not a protease. Fractionation of the microsomes indicated that the lumenal contents were not required for NS1-NS2A cleavage. It seems most likely that NS1-NS2A cleavage is effected by a host membrane-bound ER-resident protease, quite possibly signalase, and that NS2A is required to present the cleavage recognition sequence in the correct conformation to the host enzyme for cleavage.
KW  - arboviruses
KW  - cleavage
KW  - endoplasmic reticulum
KW  - membranes
KW  - proteinases
KW  - viral proteins
KW  - Flavivirus
KW  - vaccinia virus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - arthropod-borne viruses
KW  - nonstructural proteins
KW  - proteases
KW  - signalase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500281&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes.
AU  - Schubert, U.
AU  - Clouse, K. A.
AU  - Strebel, K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 12
SP  - 7699
EP  - 7711
SN  - 0022-538X
AD  - Schubert, U.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Rm 314, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19962000217.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref.
KW  - cell lines
KW  - cells
KW  - culture techniques
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - macrophages
KW  - Vpu protein
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000217&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells.
AU  - Priola, S. A.
AU  - Chesebro, B.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 12
SP  - 7754
EP  - 7758
SN  - 0022-538X
AD  - Priola, S. A.: Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1  - Accession Number: 19952221953.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - Recombinant hamster/mouse normal host PrP (PrP-sen) was expressed in scrapie-infected mouse neuroblastoma cells to identify specific PrP amino acid residues required for the conversion to protease resistant PrP (PrP-res). It was shown that homology to the region of mouse PrP-sen for residues 112 to 138 was required for conversion of recombinant PrP-sen to PrP-res in scrapie-infected mouse cells. A single hamster-specific PrP amino acid at residue 138 inhibited this conversion. The results support studies in man which show that specific amino acid residue changes within PrP can affect disease pathogenesis and transmission of transmissible spongiform encephalopathies across species barriers.
KW  - amino acids
KW  - cell cultures
KW  - disease transmission
KW  - inhibition
KW  - prions
KW  - proteinases
KW  - recombination
KW  - scrapie
KW  - spongiform encephalopathy
KW  - hamsters
KW  - mice
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - genetic recombination
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952221953&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages.
AU  - Hui, R.
AU  - Curtis, J. F.
AU  - Sumner, M. T.
AU  - Shears, S. B.
AU  - Glasgow, W. C.
AU  - Eling, T. E.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 12
SP  - 8020
EP  - 8026
SN  - 0022-538X
AD  - Hui, R.: Correspondence address: T.E. Eling, Eicosanoid Biochemistry Section, Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19962000222.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 11000-26-3. 
KW  - CD4 antigens
KW  - cells
KW  - envelope protein gp120
KW  - HIV infections
KW  - human diseases
KW  - monocytes
KW  - prostaglandins
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - gp120
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000222&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a neurologic disease induced by a polytropic murine retrovirus: evidence for differential targeting of ecotropic and polytropic viruses in the brain.
AU  - Portis, J. L.
AU  - Czub, S.
AU  - Robertson, S.
AU  - McAtee, F.
AU  - Chesebro, B.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1995///
VL  - 69
IS  - 12
SP  - 8070
EP  - 8075
SN  - 0022-538X
AD  - Portis, J. L.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 58940, USA.
N1  - Accession Number: 19962000223.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
KW  - animal models
KW  - brain
KW  - diseases
KW  - leukaemia
KW  - neurology
KW  - mice
KW  - retroviridae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - blood cancer
KW  - cerebrum
KW  - leucaemia
KW  - leukemia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000223&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation and characterization of the gene encoding the surface membrane 3′-nucleotidase/nuclease of Leishmania donovani.
AU  - Debrabant, A.
AU  - Gottlieb, M.
AU  - Dwyer, D. M.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1995///
VL  - 71
IS  - 1
SP  - 51
EP  - 63
SN  - 0166-6851
AD  - Debrabant, A.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19950807228.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 9033-33-4.  Subject Subsets: Protozoology
N2  - Leishmania donovani and related trypanosomatid protozoa possess an externally oriented surface membrane enzyme capable of hydrolyzing both 3′-nucleotides and nucleic acids. By virtue of these activities, this 3′-nucleotidase/nuclease (3′-NT/Nu), previously shown to be analogous to fungal and plant class-I single-strand-specific nucleases, is thought to play a critical role in the salvage of purines, essential for the survival of these organisms. The 43 000 MW 3′-NT/Nu was purified from L. donovani promastigotes and treated with trypsin. Four of the released tryptic peptide fragments yielded amino-acid sequence information (Pept-1 to Pept-4) which provided the basis for the preparation of oligonucleotide primers for PCR amplification of an approximately 300-bp DNA fragment. This fragment was cloned, sequenced and used to probe a genomic L. donovani cosmid library. Nucleotide sequence analysis of a 4.5-kb SmaI fragment, isolated from a cosmid clone, revealed an open reading frame (ORF) of 1434 nt encoding a 477-amino-acid protein. Pept-1 to Pept-4 were mapped onto the ORF-deduced protein sequence. Peptides corresponding to Pept-1 to Pept-4 were synthesized and used to immunize rabbits. The resulting anti-peptide antibodies recognized the 43 000 MW protein on Western blots and immunoprecipitated the native 3′-nucleotidase activity from L. donovani membrane extracts. The ORF-deduced protein shared significant sequence identity with the S1 and P1 fungal nucleases of Aspergillus oryzae and Penicillium citrinum, respectively. It is concluded that the ORF corresponds to a gene for the L. donovani 3′-nucleotidase/nuclease. In Northern blots a nucleotide probe specific for the 3′-NT/Nu gene hybridized to a single 2.5-kb messenger RNA. Results of Southern blot analyses were consistent with the 3′-NT/Nu being encoded by a single-copy gene. This constitutes the first report of the gene for this unique trypanosomatid surface membrane enzyme.
KW  - amino acid sequences
KW  - genes
KW  - molecular genetics
KW  - nucleotidase
KW  - nucleotide sequences
KW  - open reading frames
KW  - parasites
KW  - Leishmania donovani
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - ORFs
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isoprenylation of proteins in the protozoan Giardia lamblia.
AU  - Luján, H. D.
AU  - Mowatt, M. R.
AU  - Chen, G. Z.
AU  - Nash, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1995///
VL  - 72
IS  - 1/2
SP  - 121
EP  - 127
SN  - 0166-6851
AD  - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19950808188.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Protozoology
N2  - The ability of Giardia lamblia [Giardia duodenalis] to modify several of its cellular proteins by isoprenylation is reported. Trophozoites cultured in the presence of [³H]mevalonate synthesized radiolabelled proteins of about 50 000 and 21 000 to 26 000 MW. Chemical analysis indicated that farnesyl and geranylgeranyl isoprenoids comprised the majority of the radiolabel covalently associated with trophozoite proteins. In addition, antibodies to human p21ras immunoprecipitated mevalonate-labelled species of MW about 21 000. Inhibitors of several enzymatic steps of the mevalonate pathway dramatically affected Giardia metabolism. Protein isoprenylation and cell growth were blocked by compactin and mevinolin, competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme in isoprenoid biosynthesis. In the presence of these inhibitors, Giardia growth was restored by the addition of mevalonate to the culture medium. In contrast, cell growth was blocked irreversibly by inhibitors of subsequent steps in the protein isoprenylation pathway. Trophozoite growth inhibition by limonene, perillic acid, perillyl alcohol and N-acetyl-S-farnesyl-l-cysteine was not reversed after the addition of mevalonate, dolichol, ubiquinone or cholesterol to the medium. These observations constitute the first description of protein isoprenylation in any protozoan and indicate that this post-translational modification is an important step in the regulation of the growth of this primitive eukaryote.
KW  - modification
KW  - parasites
KW  - proteins
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - protein isoprenylation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808188&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The structure of the large subunit rRNA expressed in blood stages of Plasmodium falciparum.
AU  - Waters, A. P.
AU  - White, W.
AU  - McCutchan, T. F.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1995///
VL  - 72
IS  - 1/2
SP  - 227
EP  - 237
SN  - 0166-6851
AD  - Waters, A. P.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19950808201.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Protozoology
N2  - The sequence of the large subunit (LSU) rRNA expressed in blood-stage forms (and therefore A-type) of Plasmodium falciparum from 2 different isolates is presented. The genomic sequence was determined of an rRNA unit of the CAMP parasite strain from within the internal transcribed spacer 1 (ITS1) through the 5.8 S rRNA gene, the ITS2 and the entire large subunit rRNA gene. The corresponding sequence of the gene of the FVO strain was also determined by sequencing cDNA clones derived from blood-stage asexual parasites. Differences between the 2 were due to scattered point mutations in expansion segments of the mature rRNA regions. In addition to the point mutations, the rRNA genes from the 2 strains could be distinguished by the presence of a more complex polymorphism near the 3′ end of the molecule. The most complex polymorphic form was localized on a single chromosome and found in only a subset of geographically distinct isolates. The sequences of the 5.8 S rRNA unit and the LSU rRNA unit could be logically assembled into a complete secondary structure which conforms to the standard structure conserved in all eukaryotic ribosomes. The construction of a model of secondary structure for the LSU rRNA allowed the identification of phylogenetically conserved sequences involved in drug interaction with the ribosome, as well as those sequences involved in tertiary interactions within the rRNA itself.
KW  - drug resistance
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - polymorphism
KW  - ribosomal RNA
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808201&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hymenoptera, hypersensitivity, and history: a prologue to current day concepts and practices in the diagnosis, treatment, and prevention of insect sting allergy.
AU  - Cohen, S. G.
AU  - Bianchine, P. J.
JO  - Annals of Allergy, Asthma, & Immunology
JF  - Annals of Allergy, Asthma, & Immunology
Y1  - 1995///
VL  - 74
IS  - 3
SP  - 198
EP  - 221
AD  - Cohen, S. G.: National Institute of Allergy and Infectious Diseases, Solar Bldg., Rm 2C 37, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960200297.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Animal Nutrition; Human Nutrition
N2  - This review, with 147 references, deals with the evolution of the sting and the history of investigations into the nature of sting allergy and how it could be treated. There are also short sections on honey and the therapeutic uses of Hymenoptera (including honey bee) venom.
KW  - allergies
KW  - arthropod allergies
KW  - diagnosis
KW  - history
KW  - pathogenesis
KW  - stings
KW  - treatment
KW  - Hymenoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Apiculture (LL010) 
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Other Produce (QQ070) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960200297&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mapping of the intermolecular association of the human T cell leukaemia/lymphotropic virus type I p121 and the vacuolar H+-ATPase 16 kDa subunit protein.
AU  - Koralnik, I. J.
AU  - Mulloy, J. C.
AU  - Andresson, T.
AU  - Fullen, J.
AU  - Franchini, G.
JO  - Journal of General Virology
JF  - Journal of General Virology
Y1  - 1995///
VL  - 76
IS  - 8
SP  - 1909
EP  - 1916
SN  - 0022-1317
AD  - Koralnik, I. J.: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 37 Convent Dr MSC 4255, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962002121.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 147-85-3. 
KW  - human diseases
KW  - mapping
KW  - mutants
KW  - proline
KW  - proteins
KW  - vacuoles
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - cartography
KW  - HTLV-BLV group
KW  - molecules
KW  - protein biology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002121&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis.
AU  - Brindley, P. J.
AU  - Gam, A. A.
AU  - McKerrow, J. H.
AU  - Neva, F. A.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 80
IS  - 1
SP  - 1
EP  - 7
SN  - 0014-4894
AD  - Brindley, P. J.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805055.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 308067-58-5, 308067-57-4.  Subject Subsets: Helminthology; Tropical Diseases
N2  - The Strongyloides stercoralis zinc endopeptidase had a MW of 40 000 and a pI of 5 by zymogram analysis. Activity was not affected by incubation with β-mercaptoethanol at 22°C, but was inactivated by incubation at 100°C for 2 minutes. The enzyme (designated Ss40) is immunogenic and stimulates humoral IgG antibodies during infection of humans; the activity was immunoprecipitable from ES with pooled infection sera. A HPLC-enriched Ss40 preparation stimulated the release of histamine from peripheral blood leukocytes of people infected with S. stercoralis, suggesting that it is allergenic in humans.
KW  - allergens
KW  - antigens
KW  - enzymes
KW  - excretory secretory products
KW  - helminths
KW  - human diseases
KW  - IgG
KW  - immune response
KW  - immunoglobulins
KW  - larvae
KW  - parasites
KW  - proteinases
KW  - man
KW  - nematoda
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Strongyloididae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Strongyloides
KW  - Strongyloididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - antigenicity
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - proteases
KW  - Secernentea
KW  - zinc endopeptidase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Unique specificity of in vitro inhibition of mosquito midgut trypsin-like activity correlates with in vitro inhibition of malaria parasite infectivity.
AU  - Shahabuddin, M.
AU  - Criscio, M.
AU  - Kaslow, D. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 80
IS  - 2
SP  - 212
EP  - 219
SN  - 0014-4894
AD  - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950805835.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 9002-07-7.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Aedes aegypti midgut trypsin-like proteases were characterized biochemically and compared to a mammalian trypsin. Mosquito trypsin was more sensitive to inhibition by aprotinin and less sensitive to egg white trypsin inhibitor than was bovine pancreatic trypsin. Soybean trypsin inhibitor and leupeptin inhibited both enzymes to a similar extent. Membrane-feeding assays with aprotinin, leupeptin, and egg white trypsin inhibitor revealed a correlation between in vitro inhibition of mosquito trypsin-like activity and in vivo inhibition of sporogonic development (of Plasmodium gallinaceum). The trypsin inhibitors did not interfere with mosquito survival or egg development. The results suggest a role for mosquito midgut trypsin(s) in malaria parasite development and indicate that the protease(s) is a potential target for blocking malaria transmission.
KW  - biochemistry
KW  - development
KW  - disease vectors
KW  - enzyme inhibitors
KW  - host parasite relationships
KW  - infectivity
KW  - inhibition
KW  - midgut
KW  - parasites
KW  - trypsin
KW  - Aedes aegypti
KW  - Apicomplexa
KW  - Culicidae
KW  - Diptera
KW  - Plasmodiidae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - aprotinin
KW  - leupeptin
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805835&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: a refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae.
AU  - Vernick, K. D.
AU  - Fujioka, H.
AU  - Seeley, D. C.
AU  - Tandler, B.
AU  - Aikawa, M.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 80
IS  - 4
SP  - 583
EP  - 595
SN  - 0014-4894
AD  - Vernick, K. D.: Molecular Entomology Section, Laboratory of Malaria Research, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950806551.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - A mechanism for refractoriness to P. gallinaceum was identified in the African vector of human malaria, A. gambiae. Oocysts failed to develop in the refractory mosquitoes as a result of ookinete death, which occurs within 27 h of midgut invasion. Ultrastructural studies showed that parasite death occurs while the ookinete lies free in the midgut epithelial cell cytosol, usually surrounded by an organelle-free zone that consists of finely fibrillar material. The mechanism of parasite killing did not involve a previously described refractory mechanism of parasite encapsulation. Genetic lines were selected which were refractory or susceptible to midgut infection. Genetic crossing of the lines indicated that the refractory trait is inherited as a single dominant genetic locus. Other loci probably influence oocyst number in susceptible mosquitoes.
KW  - disease vectors
KW  - host parasite relationships
KW  - parasites
KW  - susceptibility
KW  - vector competence
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806551&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status.
AU  - Friedman, T. C.
AU  - Yanovski, J. A.
AU  - Jayasvasti, V.
AU  - Yanovski, S. Z.
AU  - Koenig, R. J.
AU  - Wilk, S.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1995///
VL  - 80
IS  - 4
SP  - 1086
EP  - 1089
SN  - 0021-972X
AD  - Friedman, T. C.: Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951406983.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Human Nutrition
KW  - activity
KW  - blood
KW  - body weight
KW  - hyperthyroidism
KW  - hypothyroidism
KW  - obesity
KW  - serum
KW  - thyroid gland
KW  - thyroid hormones
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - hyperthyroidosis
KW  - thyroid
KW  - thyrotoxicosis
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406983&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women.
AU  - Baird, D. D.
AU  - Umbach, D. M.
AU  - Lansdell, L.
AU  - Hughes, C. L.
AU  - Setchell, K. D. R.
AU  - Weinberg, C. R.
AU  - Haney, A. F.
AU  - Wilcox, A. J.
AU  - McLachlan, J. A.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1995///
VL  - 80
IS  - 5
SP  - 1685
EP  - 1690
SN  - 0021-972X
AD  - Baird, D. D.: National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina, NC 27709, USA.
N1  - Accession Number: 19951408068.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9002-68-0, 9002-67-9.  Subject Subsets: Human Nutrition; Soyabeans
N2  - The hypothesis that postmenopausal women on a soya-supplemented diet show oestrogenic responses was tested. 97 postmenopausal women consumed soya foods for 4 weeks or ate their usual diet (controls). Changes in urinary isoflavone concentrations served as a measure of compliance and phytoestrogen dose. Changes in serum FSH, LH, sex hormone binding globulin and vaginal cytology were measured to assess oestrogenic response. The percentage of vaginal superficial cells (indicative of oestrogenicity) increased for 19% of those eating the soya diet compared with 8% of controls (P = 0.06 when tested by ordinal logistic regression). FSH and LH did not decrease significantly with dietary supplementation as hypothesized, nor did sex hormone binding globulin increase. Little change occurred in endogenous estradiol concentration or body weight during the diet. Women with large increases in urinary isoflavone concentrations were not more likely to show oestrogenic responses than were women with more modest increases. On the basis of published estimates of phytoestrogen potency, a 4-week, soya-supplemented diet was expected to have oestrogenic effect on the liver and pituitary in post-menopausal women, but oestrogenic effects were not seen. At most, there was a small oestrogenic effect on vaginal cytology.
KW  - binding proteins
KW  - blood
KW  - cytology
KW  - FSH
KW  - LH
KW  - plant oestrogens
KW  - reproductive organs
KW  - sex hormones
KW  - soyabean products
KW  - soyabeans
KW  - supplements
KW  - vagina
KW  - women
KW  - Glycine (Fabaceae)
KW  - man
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - carrier proteins
KW  - follicle stimulating hormone
KW  - follitropin
KW  - luteinizing hormone
KW  - phytoestrogens
KW  - plant estrogens
KW  - soybean products
KW  - soybeans
KW  - Crop Produce (QQ050) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408068&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enzyme-linked immunosorbent assay for detection of serum antibody to Blastocystis hominis in symptomatic infections.
AU  - Zierdt, C. H.
AU  - Zierdt, W. S.
AU  - Nagy, B.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1995///
VL  - 81
IS  - 1
SP  - 127
EP  - 129
SN  - 0022-3395
AD  - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950804782.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Protozoology; Public Health
N2  - An enzyme-linked immunosorbent assay was devised in order to search for antibodies against Blastocystis hominis in infected humans. Reaction proteins were obtained from washed, axenic B. hominis cells, as sonicate. The sonicate was diluted to provide 17 and 34 µg of protein per well. Dilutions of patients' sera were applied, followed by phosphatase-conjugated goat anti-human serum and phosphatase substrate. Colour was measured at 405 µm wavelength. Immunoglobulin G antibodies to high titres were found. Of 30 sera tested from 28 patients, 3 were negative at the 1/50 threshold dilution, 8 were positive at 1/50, 3 at 1/100, 2 at 1/200, 3 at 1/400, 6 at 1/800, and 5 at 1/1600. Normal sera (42 blood bank sera) were all negative at 1/50. Each serum was subjected to multiple testing. Duplicate tests were included for each run, and runs were made from 4 to 6 for each serum. B. hominis is increasingly recognized to be a cause of human enteric disease, with symptoms often like those in giardiasis. Demonstration of strong antibody response is consistent with this view.
KW  - detection
KW  - ELISA
KW  - human diseases
KW  - immunodiagnosis
KW  - infections
KW  - parasites
KW  - seroprevalence
KW  - serum
KW  - blastocystis hominis
KW  - man
KW  - protozoa
KW  - Blastocystis
KW  - Amoebida incertae sedis
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - enzyme linked immunosorbent assay
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: sporozoite invasion of Aedes aegypti salivary glands is inhibited by anti-gland antibodies and by lectins.
AU  - Barreau, C.
AU  - Touray, M.
AU  - Pimenta, P. F.
AU  - Miller, L. H.
AU  - Vernick, K. D.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 81
IS  - 3
SP  - 332
EP  - 343
SN  - 0014-4894
AD  - Barreau, C.: Laboratory of Parasitic Disease, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960801357.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 308067-58-5, 308067-57-4.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Purified sporozoites from mature oocysts of Plasmodium gallinaceum were injected into Aedes aegypti. Half of the maximum invasion of salivary glands by sporozoites occurred by 6 h, and salivary gland sporozoite load did not increase after 24 h postinjection. A rabbit polyclonal antiserum was raised against female A. aegypti salivary glands which recognized tissue-specific determinants in the basal lamina of salivary glands. The purified IgG antibody fraction of the immune serum blocked sporozoite invasion in vivo. 7 of 19 lectins tested bound to salivary glands, and of these, succinylated wheat germ agglutinin and wheat germ agglutinin completely blocked sporozoite invasion. Pisum sativum agglutinin and soybean agglutinin partially blocked, and concanavalin A, Dolichos biflorus agglutinin, and Phaseolus vulgaris erythroagglutinin did not block, invasion. It is suggested that sporozoites interact with glycosylated salivary gland surface molecules, which serve as receptors for invasion, and which may be in the salivary gland basal lamina.
KW  - antibodies
KW  - disease vectors
KW  - igg
KW  - immunoglobulins
KW  - invasion
KW  - lectins
KW  - parasites
KW  - salivary glands
KW  - sporozoites
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - gamma-globulins
KW  - immune globulins
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801357&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: mosquito peritrophic matrix and the parasite-vector compatibility.
AU  - Shahabuddin, M.
AU  - Kaidoh, T.
AU  - Aikawa, M.
AU  - Kaslow, D. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 81
IS  - 3
SP  - 386
EP  - 393
SN  - 0014-4894
AD  - Shahabuddin, M.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960801359.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Sporogonic development of Plasmodium gallinaceum was studied in susceptible (Aedes aegypti and Anopheles gambiae G3) and refractory (A. stephensi) mosquitoes. In the presence of the PM (peritrophic matrix) the number of oocysts that developed in A. gambiae G3 was about 20% of that in Aedes aegypti; no oocysts developed in Anopheles stephensi. The absence of the PM did not increase the susceptibility of Aedes aegypti or Anopheles gambiae nor did it make A. stephensi susceptible. It is concluded that the PM is not the primary determinant of P. gallinaceum compatibility in these mosquitoes.
KW  - compatibility
KW  - disease vectors
KW  - host parasite relationships
KW  - parasites
KW  - peritrophic membrane
KW  - susceptibility
KW  - Aedes aegypti
KW  - Anopheles gambiae
KW  - Anopheles stephensi
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801359&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium: a quantitative molecular assay for detection of sporogonic-stage malaria parasites.
AU  - Vernick, K. D.
AU  - Barreau, C.
AU  - Seeley, D. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 81
IS  - 4
SP  - 436
EP  - 444
SN  - 0014-4894
AD  - Vernick, K. D.: Laboratory of Parasitic Disease, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960801954.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - A molecular assay for the detection of malaria parasites during sporogonic development in the mosquito host is described. Specific primers for Plasmodium-specific small-subunit ribosomal RNA sequences not present in mosquito RNA were used in a reverse transcriptase-polymerase chain reaction assay. The study was carried out using Plasmodium gallinaceum from Aedes aegypti. Ookinetes and sporozoites were both recognized in the assay. The assay allowed accurate quantification of parasite number over at least two orders of magnitude, from 10-1000 sporozoites.
KW  - detection
KW  - disease vectors
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - ribosomal RNA
KW  - techniques
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - biochemical genetics
KW  - mosquitoes
KW  - PCR
KW  - rRNA
KW  - small subunit ribosomal RNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801954&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation.
AU  - Alleman, M. M.
AU  - Mann, V. H.
AU  - Bacchi, C. J.
AU  - Yarlett, N.
AU  - Gottlieb, M.
AU  - Dwyer, D. M.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1995///
VL  - 81
IS  - 4
SP  - 519
EP  - 528
SN  - 0014-4894
AD  - Alleman, M. M.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960801963.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Protozoology
N2  - The utilization of S-adenosyl-L-[methyl-³H]methionine ([³H-methyl]AdoMet) by Crithidia luciliae was assessed under nutrient-replete and purine-starvation conditions. The radiolabel from this molecule was accumulated by purine-starved organisms at a rate about 10-fold greater than that observed in those cultivated in nutrient-replete medium. It is suggested that differences observed in [³H-methyl]AdoMet utilization between purine-starved and nutrient-replete C. luciliae may reflect the enhanced purine transport capacity which results from purine starvation.
KW  - biochemistry
KW  - methylation
KW  - parasites
KW  - proteins
KW  - purines
KW  - uptake
KW  - Crithidia luciliae
KW  - protozoa
KW  - Crithidia
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - purine bases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmaceutical prospecting and the potential for pharmaceutical crops. Natural product drug discovery and development at the United States National Cancer Institute.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
AU  - Grever, M. R.
AU  - Schepartz, S. A.
JO  - Annals of the Missouri Botanical Garden
JF  - Annals of the Missouri Botanical Garden
Y1  - 1995///
VL  - 82
IS  - 1
SP  - 47
EP  - 53
SN  - 0026-6493
AD  - Cragg, G. M.: Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950307309.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - Chemically complex natural product drugs are not readily synthesized, and large scale production for clinical and commercial development often involves isolation from the natural source. The rapidly escalating demand for taxol, originally isolated from the bark of Taxus brevifolia, has emphasized the need for alternative sources to the wild plant, and the National Cancer Institute (NCI) has developed policies for exploring such sources at the early stages of preclinical development of potential new drugs. The potential for pharmaceutical crop development is discussed with reference to plants containing possible anti-AIDS agents.
KW  - acquired immune deficiency syndrome
KW  - antiviral properties
KW  - bark
KW  - diterpenoid alkaloids
KW  - drugs
KW  - medicinal plants
KW  - medicinal properties
KW  - natural products
KW  - plant composition
KW  - production
KW  - production possibilities
KW  - research
KW  - Taxaceae
KW  - Taxus brevifolia
KW  - Taxopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Taxus
KW  - Taxaceae
KW  - AIDS
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - medicines
KW  - officinal plants
KW  - pharmaceuticals
KW  - potential production
KW  - production potential
KW  - studies
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Plant Production (FF100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950307309&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes.
AU  - Su XinZhuan
AU  - Heatwole, V. M.
AU  - Wertheimer, S. P.
AU  - Guinet, F.
AU  - Herrfeldt, J. A.
AU  - Peterson, D. S.
AU  - Ravetch, J. A.
AU  - Wellems, T. E.
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1995///
VL  - 82
IS  - 1
SP  - 89
EP  - 100
SN  - 0092-8674
AD  - Su XinZhuan: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800987.  Publication Type: Journal Article.  Language: English.  Number of References: 71 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Plasmodium falciparum evades host immunity by varying the antigenic and adhesive character of infected erythrocytes. A large and extremely diverse family of P. falciparum genes (var) that encode 200 000-350 000 proteins having the expected properties of antigenically variant adhesion molecules is described. Predicted amino acid sequences of var genes show a variable extracellular segment with domains having receptor-binding features, a transmembrane sequence and a terminal segment that is a probable submembrane anchor. There are 50-150 var genes on multiple parasite chromosomes, and some are in clustered arrangements. Probes detected two classes of var transcripts in steady-state RNA: 7.9 kb var transcripts, and an unusual family of 1.8-2.4 kb transcripts that may be involved in the expression or rearrangements of var genes.
KW  - adhesion
KW  - antigenic variation
KW  - antigens
KW  - chromosomes
KW  - erythrocytes
KW  - gene expression
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - rna probes
KW  - transcription
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - biochemical genetics
KW  - blood red cells
KW  - DNA sequences
KW  - DNA transcription
KW  - immunogens
KW  - red blood cells
KW  - variant surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800987&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Switches in expression of Plasmodium falciparumvar genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.
AU  - Smith, J. D.
AU  - Chitnis, C. E.
AU  - Craig, A. G.
AU  - Roberts, D. J.
AU  - Hudson-Taylor, D. E.
AU  - Peterson, D. S.
AU  - Pinches, R.
AU  - Newbold, C. I.
AU  - Miller, L. H.
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1995///
VL  - 82
IS  - 1
SP  - 101
EP  - 110
SN  - 0092-8674
AD  - Smith, J. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800989.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Plasmodium falciparum expresses clonally variant antigens and ligands on the host erythrocyte surface that mediate adherence to endothelial receptors. Both are central to pathogenesis since they allow chronicity of infection and lead to the concentration of infected erythrocytes in cerebral blood vessels. The expression of variant antigenic determinants is shown to be correlated with the expression of individual members of a large multigene family named var. Each var gene contains copies of a motif that has been previously shown to bind diverse host receptors. Expression of a specific var gene correlated with binding to intercellular adhesion molecule 1 (ICAM-1). The findings are consistent with the involvement of var genes in antigenic variation and endothelial binding.
KW  - adhesion
KW  - antigenic variation
KW  - antigens
KW  - binding sites
KW  - blood vessels
KW  - brain
KW  - endothelium
KW  - erythrocytes
KW  - genes
KW  - ligands
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - pathogenicity
KW  - receptors
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - binding site
KW  - biochemical genetics
KW  - blood red cells
KW  - cerebrum
KW  - DNA sequences
KW  - immunogens
KW  - red blood cells
KW  - variant surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800989&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Primary mycotic abscess of the brain caused by Fonsecaea pedrosoi. Case report.
AU  - Vani Santosh
AU  - Neelam Khanna
AU  - Shankar, S. K.
AU  - Lily Pal
AU  - Sarala Das
AU  - Akepatti Chandramukhi
AU  - Kolluri, V. R. S.
JO  - Journal of Neurosurgery
JF  - Journal of Neurosurgery
Y1  - 1995///
VL  - 82
IS  - 1
SP  - 128
EP  - 130
SN  - 0022-3085
AD  - Vani Santosh: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India.
N1  - Accession Number: 19951201701.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a non-immunocompromised 15-yr-old boy from India who presented with a 4-month history of headache, vomiting and blurred vision, and a 10-d history of right sensory seizures. Computed tomography of the head revealed a large, well-demarcated mixed density lesion with cystic areas and focal calcification in the left temporal region. The abscess was surgically removed. Histopathological examination of the resected lesion revealed brown-pigmented fungal hyphae and F. pedrosoi was cultured. The patient recovered completely after surgery and treatment with amphotericin B and flucytosine.
KW  - brain
KW  - case reports
KW  - children
KW  - hosts
KW  - human diseases
KW  - infections
KW  - phaeohyphomycosis
KW  - India
KW  - man
KW  - Phialophora pedrosoi
KW  - Fonsecaea
KW  - Herpotrichiellaceae
KW  - Chaetothyriales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - Phialophora
KW  - cerebrum
KW  - chromomycosis
KW  - Fonsecaea pedrosoi
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201701&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - EEG abnormalities, malnutrition, parasitism and goitre: a study of schoolchildren in Ecuador.
AU  - Levav, M.
AU  - Cruz, M. E.
AU  - Mirsky, A. F.
JO  - Acta Paediatrica
JF  - Acta Paediatrica
Y1  - 1995///
VL  - 84
IS  - 2
SP  - 197
EP  - 202
SN  - 0803-5253
AD  - Levav, M.: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Building 10, Room 4C110, 10 Center DR MSC 1366 Bethesda, MD 20892-1366, USA.
N1  - Accession Number: 19951408428.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 7553-56-2.  Subject Subsets: Human Nutrition; Protozoology; Helminthology; Tropical Diseases
N2  - Data collected from 194 school children (9 to 13 years old) residing in a mountainous community in Ecuador are reported. This study was part of an ongoing epidemiological inquiry into the prevalence of parasitism, malnutrition, neurocysticercosis, goitre, iodine levels and EEG abnormalities, and the relationships among these factors. Data were obtained by a local medical team supported by specialized personnel. The results showed that 34% of the EEG tracings were abnormal, with higher rates among girls. The best fitted log-linear model to explain the results was the combination of EEG status, parasite infection, goitre and gender. The best predictor of EEG abnormalities was found to be a diagnosis of goitre.
KW  - children
KW  - electroencephalography
KW  - epidemiology
KW  - goitre
KW  - health
KW  - helminths
KW  - iodine
KW  - malnutrition
KW  - metacestodes
KW  - parasites
KW  - parasitoses
KW  - school children
KW  - surveys
KW  - Ecuador
KW  - South America
KW  - Ascaris lumbricoides
KW  - Enoplida
KW  - man
KW  - protozoa
KW  - Taenia solium
KW  - Trichuris trichiura
KW  - Ascaris
KW  - Ascarididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - Trichuris
KW  - Trichuridae
KW  - Trichinellida
KW  - Dorylaimia
KW  - Enoplea
KW  - Enoplia
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Adenophorea
KW  - Ascaridida
KW  - EEG
KW  - goiter
KW  - nematodes
KW  - parasitic diseases
KW  - parasitic infestations
KW  - parasitic worms
KW  - parasitosis
KW  - pork tapeworm
KW  - school kids
KW  - schoolchildren
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408428&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication.
AU  - Foli, A.
AU  - Saville, M. W.
AU  - Baseler, M. W.
AU  - Yarchoan, R.
JO  - Blood
JF  - Blood
Y1  - 1995///
VL  - 85
IS  - 8
SP  - 2114
EP  - 2123
SN  - 0006-4971
AD  - Foli, A.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005763.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref.
KW  - cell mediated immunity
KW  - cytokines
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - interleukins
KW  - replication
KW  - T lymphocytes
KW  - viral replication
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cellular immunity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - TH1 responses
KW  - TH2 responses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005763&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular mechanisms of human T-cell leukemia/lymphotropic virus type 1 infection.
AU  - Franchini, G.
JO  - Blood
JF  - Blood
Y1  - 1995///
VL  - 86
IS  - 10
SP  - 3619
EP  - 3639
SN  - 0006-4971
AD  - Franchini, G.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962000656.  Publication Type: Journal Article.  Language: English.  Number of References: 318 ref.
KW  - clinical aspects
KW  - genetics
KW  - HTLV-I infections
KW  - human diseases
KW  - pathogenesis
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - proliferation
KW  - tropical spastic parapareses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000656&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adenocarcinoma of the esophagus: role of obesity and diet.
AU  - Brown, L. M.
AU  - Swanson, C. A.
AU  - Gridley, G.
AU  - Swanson, G. M.
AU  - Schoenberg, J. B.
AU  - Greenberg, R. S.
AU  - Silverman, D. T.
AU  - Pottern, L. M.
AU  - Hayes, R. B.
AU  - Schwartz, A. G.
AU  - Liff, J. M.
AU  - Fraumeni, J. F., Jr.
AU  - Hoover, R. N.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1995///
VL  - 87
IS  - 2
SP  - 104
EP  - 109
SN  - 0027-8874
AD  - Brown, L. M.: National Institutes of Health, Executive Plaza North, Rm 415, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951408425.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Human Nutrition
N2  - This study investigates dietary and nutritional risk factors for adenocarcinoma of the oesophagus. 174 white men (30 to 79 years old) with adenocarcinoma of the oesophagus and 750 control subjects living in 3 areas of the USA were studied during 1986 through 1989. Risk was significantly elevated for subjects in the heaviest quartile compared with the lightest quartile of body mass index (odds ratio (OR) = 3.1; 95% confidence interval [C1] = 1.8-5.3). No significant associations were seen with the total energy intake, number of meals eaten daily, fat intake or consumption of coffee and tea. Risks were highest for those consuming the least amount of vegetables, with some evidence of a dose response for the subcategories of cruciferous vegetables (P≤0.001) and vegetables consumed raw (P=0.10). An elevated risk was also seen for those consuming the least amount of raw fruit (P=0.05). No clear associations were reported for intake of particular micronutrients overall or in supplements, but a protective effect was associated with increasing intake of dietary fibre (P=0.004). It is concluded that an increased risk with obesity and decreased risks with intake of raw fruits and vegetables, and dietary fibre are found.
KW  - carcinoma
KW  - diet studies
KW  - fibre
KW  - fruits
KW  - obesity
KW  - oesophagus
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - esophagus
KW  - fatness
KW  - fiber
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408425&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent cancer trends in the United States.
AU  - Devesa, S. S.
AU  - Blot, W. J.
AU  - Stone, B. J.
AU  - Miller, B. A.
AU  - Tarone, R. E.
AU  - Fraumeni, J. F. Jr
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1995///
VL  - 87
IS  - 3
SP  - 175
EP  - 182
SN  - 0027-8874
AD  - Devesa, S. S.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892-7368, USA.
N1  - Accession Number: 19952002941.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Subject Subsets: Public Health
N2  - Cancer incidence rates have been reported to be increasing in the USA, although trends vary according to form of cancer. The authors identified the cancers accounting for the rising incidence, quantified the changes that occurred from the mid-1970s to the early 1990s. They subsequently compared incidence and mortality trends to provide clues to the determinants of the temporal patterns. Sex-, race-, and age-specific and age-adjusted incidence rates for the 5-year periods 1987-1991 versus 1975-1979 were calculated for 28 cancers among men and 30 cancers among women using data from the Surveillance, Epidemiology, and End Results (SEER) Programme of cancer registration covering about 10% of the US population. Similar rates were computed using national mortality data. Cancers were ranked according to the change in incidence rates over the 2 periods. The age-adjusted incidence rates for all cancers combined increased by 18.6% among males and 12.4% among females from 1975-1979 to 1987-1991, due largely to rising rates for prostate cancer among men and for breast and lung cancers among women. National mortality rates for all cancers combined rose less steeply, 3% and 6% among men and women, respectively, driven mostly by continuing increases in lung cancer mortality, while death rates for the majority of the cancers were steady or declining. Total cancer incidence rose at all ages, but with different tumours responsible for the increases at different ages: leukaemia and brain/nervous system cancer among children; testicular cancer, non-melanoma skin cancer (largely Kaposi's sarcoma), non-Hodgkin's lymphoma, and melanoma among young and middle-aged adults; and prostate, breast, and lung cancers among older individuals. In contrast, mortality rates for all cancers combined declined among both males and females under 55 years of age, increasing only among older persons. Trends in cancer incidence and mortality differ. For most cancers, incidence rates are rising, while mortality rates are generally stable or declining. Much of the recent increase in cancer incidence can be explained by known factors. Improved detection appears to account for most of the increases in breast cancer among women and prostate cancer among men. On the other hand, cigarette smoking is the major determinant of the rise in lung cancer among women, acquired immunodeficiency syndrome has led to increases in non-Hodgkin's lymphoma and Kaposi's sarcoma among young and middle-aged men, and sunlight exposure patterns have affected the trends in melanoma. Some trends remain unexplained, however, and may reflect changing exposures to carcinogens yet to be identified and clarified.
KW  - disease prevalence
KW  - human diseases
KW  - neoplasms
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002941&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Japanese encephalitis virus antigen in the human brain and its topographic distribution.
AU  - Desai, A.
AU  - Shankar, S. K.
AU  - Ravi, V.
AU  - Chandramuki, A.
AU  - Gourie-Devi, M.
JO  - Acta Neuropathologica
JF  - Acta Neuropathologica
Y1  - 1995///
VL  - 89
IS  - 4
SP  - 368
EP  - 373
SN  - 0001-6322
AD  - Desai, A.: Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India.
N1  - Accession Number: 19960500737.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - This study reports the pathological findings and the distribution of viral antigen in the brains of 13 confirmed and autopsied cases of Japanese encephalitis (JE) in correlation with other virus-specific immunological parameters measured in the cerebrospinal fluid (CSF) antemortem. JE virus (JEV)-specific antibodies were detected in the CSF of 10 of 13 patients, JEV antigen was detected in the CSF of 7 of 13 and JEV-specific immune complexes were detected in the CSF of 3 of 11 patients. Viral antigen was localized immunocytochemically in the brain tissue of 11 of 13 cases, indicating that viral antigen could not be cleared from the tissues by the antibody. The topographic distribution of the tissue-associated antigen in the thalamus, hippocampus, substantia nigra and medulla oblongata explains the evolution of post JE sequelae.
KW  - antigens
KW  - arboviruses
KW  - brain
KW  - cerebrospinal fluid
KW  - human diseases
KW  - Japanese encephalitis
KW  - nervous system diseases
KW  - India
KW  - Karnataka
KW  - Japanese encephalitis virus
KW  - man
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - antigenicity
KW  - arthropod-borne viruses
KW  - cerebrum
KW  - immunogens
KW  - Mysore
KW  - neuropathy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500737&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transfection of Plasmodium falciparum within human red blood cells.
AU  - Wu, Y.
AU  - Sifri, C. D.
AU  - Lei, H. H.
AU  - Su, X. Z.
AU  - Wellems, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 4
SP  - 973
EP  - 977
SN  - 0027-8424
AD  - Wu, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803865.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9040-07-7, 9007-49-2.  Subject Subsets: Protozoology
N2  - Plasmodium falciparum within human erythrocytes were successfully transfected to produce chloramphenicol acetyltransferase (CAT). Electroporation of parasitized erythrocytes was used to introduce plasmids that had CAT-encoding DNA flanked by 5′ and 3′ untranslated sequences of the P. falciparum hsp86, hrp3 and hrp2 genes. These flanking sequences were required for expression as their excision abolished CAT activity in transfected parasites. Transfection signals from native CAT-encoding DNA compared well with those from a synthetic DNA sequence adapted to the P. falciparum major codon bias, demonstrating effective expression of the bacterial sequence despite its use of rare P. falciparum codons. Transfected ring-stage parasites produced CAT signals at least as strong as transfected schizont-stage parasites, even though ring stages are surrounded by more erythrocyte cytoplasm than schizonts.
KW  - chloramphenicol acetyltransferase
KW  - developmental stages
KW  - DNA
KW  - erythrocytes
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - schizonts
KW  - transfection
KW  - Apicomplexa
KW  - Plasmodiidae
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Haemospororida
KW  - Apicomplexa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - biochemical genetics
KW  - blood red cells
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - growth phase
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803865&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.
AU  - Shirasaka, T.
AU  - Kavlick, M. F.
AU  - Ueno, T.
AU  - Gao, W. Y.
AU  - Kojima, E.
AU  - Alcaide, M. L.
AU  - Chokekijchai, S.
AU  - Roy, B. M.
AU  - Arnold, E.
AU  - Yarchoan, R.
AU  - Mitsuya, H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 6
SP  - 2398
EP  - 2402
SN  - 0027-8424
AD  - Shirasaka, T.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006471.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 9068-38-6. 
KW  - dideoxynucleosides
KW  - drug combinations
KW  - drug resistance
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mutations
KW  - reverse transcriptase
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006471&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Angiogenic properties of human immunodeficiency virus type 1 Tat protein.
AU  - Albini, A.
AU  - Barillari, G.
AU  - Benelli, R.
AU  - Gallo, R. C.
AU  - Ensoli, B.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 11
SP  - 4838
EP  - 4842
SN  - 0027-8424
AD  - Albini, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002086.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
KW  - acquired immune deficiency syndrome
KW  - angiogenesis
KW  - cytokines
KW  - development
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - Tat protein
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002086&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transient transfection and expression of firefly luciferase in Giardia lamblia.
AU  - Yee, J.
AU  - Nash, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 12
SP  - 5615
EP  - 5619
SN  - 0027-8424
AD  - Yee, J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800443.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9007-49-2, 9001-46-1, 9029-11-2, 9029-12-3.  Subject Subsets: Protozoology
N2  - A gene transfer system was developed for Giardia lamblia [G. duodenalis], which is considered to be one of the most primitive eukaryotes. Expression of a heterologous gene was detected in this parasite after electroporation with appropriate DNA constructs. A series of transfection plasmids was constructed, using flanking sequences of the G. lamblia glutamate dehydrogenase (GDH) gene to drive expression of the firefly luciferase reporter gene. The optimal construct consisted of a GDH/luciferase fusion gene in which the first 18 codons of the GDH gene immediately preceded the luciferase gene; this fusion gene was flanked by the upstream and downstream sequences of the GDH gene. Electroporation of this construct into G. lamblia yielded luciferase activity that was 3000- to 50 000-fold above background. Removal of either the 5′ or 3′ GDH flanking sequences from this construct resulted in significantly reduced luciferase activity, and removal of both flanking sequences reduced luciferase activity to background levels. Luciferase activity was proportional to the amount of DNA electroporated and was maximal 6 h after electroporation.
KW  - DNA
KW  - electroporation
KW  - gene transfer
KW  - genes
KW  - glutamate dehydrogenase
KW  - luciferases
KW  - molecular genetics
KW  - parasites
KW  - plasmids
KW  - reporter genes
KW  - transfection
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - luciferase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800443&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues.
AU  - Jenkins, T. M.
AU  - Hickman, A. B.
AU  - Dyda, F.
AU  - Ghirlando, R.
AU  - Davies, D. R.
AU  - Craigie, R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 13
SP  - 6057
EP  - 6061
SN  - 0027-8424
AD  - Jenkins, T. M.: Correspondence address: R. Craigie, Building 5, Room 301, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001915.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - genomes
KW  - HIV infections
KW  - human diseases
KW  - hydrophobicity
KW  - molecular biology
KW  - mutants
KW  - proteins
KW  - residues
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001915&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Direct evidence for secondary loss of mitochondria in Entamoeba histolytica.
AU  - Clark, C. G.
AU  - Roger, A. J.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 14
SP  - 6518
EP  - 6521
SN  - 0027-8424
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960803795.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Protozoology
N2  - Archezoan protists are thought to represent lineages that diverged from other eukaryotes before the acquisition of mitochondria and other organelles. Entamoeba histolytica was originally included in this group, although ribosomal RNA-based phylogenies have placed this species on a comparatively recent branch of the eukaryotic tree which implies its ancestors had mitochondria. In this study, direct evidence for 2ndary loss of mitochondrial function was obtained by isolating 2 E. histolytica genes encoding proteins that in other eukaryotes are localized in the mitochondrion: the enzyme pyridine nucleotide transhydrogenase and the chaperonin cpn60. Phylogenetic analysis of the E. histolytica homologue of cpn60 confirmed that it is specifically related to the mitochondrial lineage. The data suggest that a mitochondrial relic may persist in this organism.
KW  - genes
KW  - mitochondria
KW  - molecular genetics
KW  - organelles
KW  - parasites
KW  - phylogeny
KW  - proteins
KW  - ribosomal RNA
KW  - Entamoeba histolytica
KW  - eukaryotes
KW  - protozoa
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803795&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.
AU  - Müller, J. R.
AU  - Janz, S.
AU  - Goedert, J. J.
AU  - Potter, M.
AU  - Rabkin, C. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 14
SP  - 6577
EP  - 6581
SN  - 0027-8424
AD  - Müller, J. R.: Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972005585.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 308067-57-4. 
N2  - Blood lymphocytes of HIV-seropositive and HIV-negative homosexual men from the USA, were studied for the presence of T(8;14) translocations that recombine c-myc and immunoglobulin heavy-chain (IgH) µ/IgHα switch regions. Clones with T(8;14) translocations were detected in 12 (10.5%) of 114 HIV-positive and in 2.0% of 99 uninfected patients. The majority of recombinations were found at a single time point only. Four patients, however, harboured multiple (up to four) and persistent (up to 9 years) translocation-positive cell clones. No correlation between the presence of these aberrant lymphocytes and a later lymphoma was established. The exon 1/intron 1 region of the recombined c-myc was investigated for the presence of point mutations and these were found in the nonpersistent clones. Additional alterations detected in these clones included duplications and a deletion in the c-myc gene. The pattern of base substitutions indicated that they were introduced after the translocation event.
KW  - blood
KW  - hiv infections
KW  - homosexuality
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunoglobulins
KW  - men
KW  - t lymphocytes
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - gamma-globulins
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune globulins
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005585&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins.
AU  - Peterson, D. S.
AU  - Miller, L. H.
AU  - Wellems, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 15
SP  - 7100
EP  - 7104
SN  - 0027-8424
AD  - Peterson, D. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960801008.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Protozoology
N2  - Open reading frames in the Plasmodium falciparum genome encode domains homologous to the adhesive domains of the P. falciparum EBA-175 erythrocyte-binding protein (eba-175 gene product) and those of the P. vivax and P. knowlesi Duffy antigen-binding proteins. These domains are referred to as Duffy binding-like (DBL), after the receptor that determines P. vivax invasion of Duffy blood group-positive human erythrocytes. Using oligonucleotide primers derived from short regions of conserved sequence, a reverse transcription-PCR method was developed that amplified sequences encoding the DBL domains of expressed genes. Products of these reverse transcription-PCR amplifications included sequences of single-copy genes (including eba-175) and variably transcribed genes that cross-hybridized to multiple regions of the genome. Restriction patterns of the multicopy genes showed a high degree of polymorphism among different parasite lines, whereas single-copy genes were generally conserved. Characterization of the single-copy genes has identified a gene (ebl-1) that is related to eba-175 and is likely to be involved in erythrocyte invasion.
KW  - adhesion
KW  - binding
KW  - cell invasion
KW  - erythrocytes
KW  - genes
KW  - genomes
KW  - host parasite relationships
KW  - molecular genetics
KW  - nucleotide sequences
KW  - open reading frames
KW  - parasites
KW  - polymerase chain reaction
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - blood red cells
KW  - DNA sequences
KW  - erythrocyte binding protein
KW  - ORFs
KW  - parasite host relationships
KW  - PCR
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Disparate actions of hydroxyurea in potentiation of purine and pyrimidine 2′,3′-dideoxynucleoside activities against replication of human immunodeficiency virus.
AU  - Gao WenYi
AU  - Johns, D. G.
AU  - Chokekijchai, S.
AU  - Mitsuya, H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 18
SP  - 8333
EP  - 8337
SN  - 0027-8424
AD  - Gao WenYi: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007153.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 127-07-1. 
KW  - antiviral agents
KW  - dideoxynucleosides
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - hydroxycarbamide
KW  - purines
KW  - pyrimidines
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - hydroxyurea
KW  - purine bases
KW  - pyrimidine bases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Passive immunotherapy for retroviral disease: influence of major histocompatibility complex type and T-cell responsiveness.
AU  - Hasenkrug, K. J.
AU  - Brooks, D. M.
AU  - Chesebro, B.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 23
SP  - 10492
EP  - 10495
SN  - 0027-8424
AD  - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19972001019.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - disease course
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunotherapy
KW  - major histocompatibility complex
KW  - medical treatment
KW  - passive immunity
KW  - t lymphocytes
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - disease progression
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death.
AU  - Kolesnitchenko, V.
AU  - Wahl, L. M.
AU  - Tian, H.
AU  - Sunila, I.
AU  - Tani, Y.
AU  - Hartmann, D. P.
AU  - Cossman, J.
AU  - Raffeld, M.
AU  - Orenstein, J.
AU  - Samelson, L. E.
AU  - Cohen, D. I.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 25
SP  - 11889
EP  - 11893
SN  - 0027-8424
AD  - Kolesnitchenko, V.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development.
N1  - Accession Number: 19962003504.  Publication Type: Journal Article.  Language: English. 
KW  - apoptosis
KW  - cell cycle
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pathogenesis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003504&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element.
AU  - Nasioulas, G.
AU  - Hughes, S. H.
AU  - Felber, B. K.
AU  - Whitcomb, J. M.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1995///
VL  - 92
IS  - 25
SP  - 11940
EP  - 11944
SN  - 0027-8424
AD  - Nasioulas, G.: National Cancer Institute Frederick Cancer Research and Development Center, PO Box B, Building 539, Frederick&lt; MD 21702-1201, USA.
N1  - Accession Number: 19962003582.  Publication Type: Journal Article.  Language: English.  Number of References: 74 ref.
KW  - gene expression
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Rev protein
KW  - Avian leukosis virus
KW  - Retroviridae
KW  - Alpharetrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - avian oncovirus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003582&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans.
AU  - Rader, D. J.
AU  - Mann, W. A.
AU  - Cain, W.
AU  - Kraft, H. G.
AU  - Usher, D.
AU  - Zech, L. A.
AU  - Hoeg, J. M.
AU  - Davignon, J.
AU  - Lupien, P.
AU  - Grossman, M.
AU  - Wilson, J. M.
AU  - Brewer, H. B., Jr.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1995///
VL  - 95
IS  - 3
SP  - 1403
EP  - 1408
SN  - 0021-9738
AD  - Rader, D. J.: Molecular Disease Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951413553.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Lipoprotein (a) (LP(a)) is an atherogenic lipoprotein which is similar in structure to LDL. The role of the LDL receptor in the catabolism of Lp(a) has been controversial. An investigation of the in vivo catabolism of Lp(a) and LDL in 5 unrelated patients with homozygous familial hypercholesterolemia (FH) with have little or no LDL receptor activity was made. Purified 125I-Lp(a) and 131I-LDL were simultaneously injected into the homozygous FH patients, their heterozygous FH parents when available and control subjects. The disappearance of plasma radioactivity was followed over time. As expected, the fractional catabolic rates (FCR) of 131I-LDL were markedly decreased in the homozygous FH patients (mean LDL FCR 0.190 day-1) and somewhat decreased in the heterozygous FH parents (mean LDL FCR 0.294 day-1). In contrast, the catabolism of 125I-Lp(a) was not significantly different in the homozygous FH patients (mean FCR 0.251 day-1), heterozygous FH parents (mean FCR 0.287 day-1). In summary, absence of a functional LDL receptor does not result in delayed catabolism of Lp(a), indicating that the LDL receptor is not a physiologically important route of Lp(a) catabolism in man.
KW  - atherosclerosis
KW  - cholesterol
KW  - hypercholesterolaemia
KW  - lipoproteins
KW  - low density lipoprotein
KW  - metabolism
KW  - receptors
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.
AU  - Fiorelli, V.
AU  - Gendelman, R.
AU  - Markham, P. D.
AU  - Ensoli, B.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1995///
VL  - 95
IS  - 4
SP  - 1723
EP  - 1734
SN  - 0021-9738
AD  - Fiorelli, V.: Correspondence address: B. Ensoli, Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962001598.  Publication Type: Journal Article.  Language: English.  Number of References: 79 ref.
KW  - acquired immune deficiency syndrome
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - pathogenesis
KW  - T lymphocytes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - endothelial cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001598&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Improving food frequency questionnaires: a qualitative approach using cognitive interviewing.
AU  - Subar, A. F.
AU  - Thompson, F. E.
AU  - Smith, A. F.
AU  - Jobe, J. B.
AU  - Ziegler, R. G.
AU  - Potischman, N.
AU  - Schatzkin, A.
AU  - Hartman, A.
AU  - Swanson, C.
AU  - Kruse, L.
AU  - Hayes, R. B.
AU  - Lewis, D. R.
AU  - Harlan, L. C.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1995///
VL  - 95
IS  - 7
SP  - 781
EP  - 788
SN  - 0002-8223
AD  - Subar, A. F.: National Cancer Institute, Division of Cancer Prevention and Control, EPN 313, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19951410376.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - In an attempt to improve data quality and ease of administration of standard self-administered food frequency questionnaires, various alternative approaches were tried for inquiring about frequency of consumption, portion size, seasonal intake and food preparation. Evaluation consisted of a cognitive interviewing method in which respondents verbalize their thought process while completing several variations of a questionnaire. Interviewers observed and asked follow-up probe questions to evaluate problems or inconsistencies verbalized by respondents. Consensus and judgement by interviewers and observers suggested several problematic features of food frequency questionnaires: formatting of questions about frequency and portion size; computing average frequencies for aggregated food items or for foods eaten seasonally; comprehension of many items; and ordering of foods. These findings led to cognitive refinement and innovations, which included detailed questions regarding preparation or use of low-fat varieties or other alternatives to help better describe specifics of intake for some foods; questions on seasonal intake for several foods; inclusion of portion size ranges; and additional response categories for frequency of intake. Cognitive interviewing is an important step in pinpointing cognitive problems in dietary questionnaires.
KW  - diet
KW  - diet studies
KW  - diet study techniques
KW  - questionnaires
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trends in use of vitamin and mineral supplements in the United States: the 1987 and 1992 National Health Interview Surveys.
AU  - Slesinski, M. J.
AU  - Subar, A. F.
AU  - Kahle, L. L.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1995///
VL  - 95
IS  - 8
SP  - 921
EP  - 923
SN  - 0002-8223
AD  - Slesinski, M. J.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 313, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19951411794.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Human Nutrition
KW  - adults
KW  - diet studies
KW  - mineral supplements
KW  - minerals
KW  - vitamin supplements
KW  - vitamins
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy.
AU  - Sinnwell, T. M.
AU  - Sivakumar, K.
AU  - Soueidan, S.
AU  - Jay, C.
AU  - Frank, J. A.
AU  - McLaughlin, A. C.
AU  - Dalakas, M. C.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1995///
VL  - 96
IS  - 1
SP  - 126
EP  - 131
SN  - 0021-9738
AD  - Sinnwell, T. M.: Correspondence address: M. C. Dalakas, Building 10, Room 4N248, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001613.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 30516-87-1. 
KW  - adverse effects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - medical treatment
KW  - metabolism
KW  - muscles
KW  - muscular diseases
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - AZT
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - myopathy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Linkage between obesity and a marker near the tumor necrosis factor-α locus in Pima Indians.
AU  - Norman, R. A.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1995///
VL  - 96
IS  - 1
SP  - 158
EP  - 162
SN  - 0021-9738
AD  - Norman, R. A.: National Institutes of Health, 4214 N, 16th Street, Phoenix, AZ 85016-5319, USA.
N1  - Accession Number: 19951412516.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 308079-78-9.  Subject Subsets: Human Nutrition
N2  - Pima Indians were scored for genotypes at 3 polymorphic dinucleotide repeat loci (markers) near the gene tumour necrosis factor-α (TNF-α) at 6p21,3. In a sibling-pair linkage analysis, percent body fat, as measured by hydrostatic weighing, was linked to the marker closest to TNF-α. The same marker was associated by analysis of variance with body mass index (BMI). To search for possible DNA variants in TNF-α that contribute to obesity, single stranded conformational polymorphism analysis was performed for 20 obese and 20 lean subjects. Primer pairs were designed for the entire TNF-α protein coding region and part of the promoter. Only a single polymorphism located in the promoter region was detected. No association could be demonstrated between alleles at this polymorphism and percent body fat. It is concluded that the linkage of TNF-α to obesity may be due to a sequence variant undetected in TNF-α or due to a variant in some other closely linked gene.
KW  - diabetes
KW  - ethnic groups
KW  - genetics
KW  - linkage
KW  - obesity
KW  - tumour necrosis factor
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cachectin
KW  - cachexin
KW  - fatness
KW  - tumor necrosis factor
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412516&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro.
AU  - McNeely, T. B.
AU  - Dealy, M.
AU  - Dripps, D. J.
AU  - Orenstein, J. M.
AU  - Eisenberg, S. P.
AU  - Wahl, S. M.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1995///
VL  - 96
IS  - 1
SP  - 456
EP  - 464
SN  - 0021-9738
AD  - McNeely, T. B.: Building 30, Room 329, National Institute of Dental Research, National Institutes of Health, 30 Convent Drive, MSC 4352, Bethesda, MD 20892-4352, USA.
N1  - Accession Number: 19962001614.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref.
KW  - antiviral agents
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - proteinase inhibitors
KW  - proteins
KW  - saliva
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - protease inhibitors
KW  - salivary secretions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001614&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
AU  - Kadiiska, M. B.
AU  - Burkitt, M. J.
AU  - Xiang, Q. H.
AU  - Mason, R. P.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1995///
VL  - 96
IS  - 3
SP  - 1653
EP  - 1657
SN  - 0021-9738
AD  - Kadiiska, M. B.: National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
N1  - Accession Number: 19951412078.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 7439-89-6.  Subject Subsets: Human Nutrition
N2  - Electron spin resonance (ESR) spectroscopy was used to investigate hydroxyl radical generation in Sprague-Dawley rats with chronic dietary iron loading. A secondary radical spin-trapping technique was used where hydroxyl radicals form methyl radicals upon reaction with dimethyl sulfoxide (DMSO). The methyl radical was then detected by ESR spectroscopy as its adduct with the spin trap α-phenyl-N-t-butylnitrone (PBN). This adduct was detected in the bile of rats 10 weeks after being given an iron-loading diet and 40 min after the intraperitoneal injection of the spin trap PBN dissolved in DMSO. Bile samples were collected into a solution of the ferrous stabilizing chelator 2,2′-dipyridyl in order to prevent the generation of radical adducts ex vivo during bile collection. Identification of the ESR spectrum of the major radical adduct as that of PBN/CH3 provides evidence for the generation of the hydroxyl radical during iron supplementation. Desferal completely inhibited in vivo hydroxyl radical generation stimulated by high dietary iron intake. No radical adducts were detected in rats which were given the control diet for the same period of time. This is the first evidence of hydroxyl radical generation in chronic iron-loaded rats.
KW  - free radicals
KW  - intake
KW  - iron
KW  - minerals
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum D-arabinitol.
AU  - Walsh, T. J.
AU  - Merz, W. G.
AU  - Lee, J. W.
AU  - Schaufele, R.
AU  - Sein, T.
AU  - Whitcomb, P. O.
AU  - Ruddel, M.
AU  - Burns, W.
AU  - Wingard, J. R.
AU  - Switchenko, A. C.
AU  - Goodman, T.
AU  - Pizzo, P. A.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1995///
VL  - 99
IS  - 2
SP  - 164
EP  - 172
SN  - 0002-9343
AD  - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19951203069.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 2152-56-9.  Subject Subsets: Medical & Veterinary Mycology
N2  - A rapid automated enzymatic assay was used to investigate serum D-arabinitol (DA) in a large population of high-risk patients to determine its potential diagnostic, therapeutic and prognostic significance in invasive Candida infection. A total of 3223 serum samples were collected from 274 cancer patients at 2 oncology centres in the USA. Serum DA concn were determined in coded serum samples analysed by rapid enzymatic assay. Creatinine was also analysed in the same system to determine a serum DA and creatinine ratio (DA/Cr). The sensitivity, specificity, correlation with therapeutic response and prognostic significance were analysed for all patient study groups. Infections were due to C. albicans, C. tropicalis, Torulopsis glabrata, C. parapsilosis, C. krusei, C. lusitaniae and C. guilliermondii. A DA/Cr of ≥4.0 µmol/litre per mg/dl was detected in 31 of 42 cases (74%) of fungaemia and 25 of 30 cases (83%) of the subset of persistent fungaemia. Elevated DA/Cr was detected in 4 of 10 patients (40%) with tissue-proven, deeply invasive candidosis and negative blood cultures and 7 of 16 cases (44%) of deep mucosal candidosis. Elevated serial DA/Cr levels also were detected in persistently febrile and granulocytopenic patients requiring empirical amphotericin B. Among 26 assessable cases of fungaemia, abnormally elevated DA/Cr values were detected in 14 (54%) before, 10 (38%) after and 2 (8%) simultaneously with the first microbiological report of fungaemia. The trends of serial DA/Cr values correlated with therapeutic response in 29 (85%) of 34 patients with assessable cases of fungaemia, decreasing in 8 of 9 patients (89%) with clearance of fungaemia and increasing in 21 of 25 patients (84%) with persistence of fungaemia. Among the 34 assessable patients with fungaemia, mortality was directly related to the trend of serial DA/Cr determinations over time: 71% among fungaemic patients with persistently elevated or increasing DA/Cr, and 18% among the fungaemic patients with resolving DA/Cr or who never had elevated DA/Cr (P&lt;0.01). Rapid enzymatic detection of DA in serially collected serum samples from high-risk cancer patients permitted detection of invasive candidosis, early recognition of fungaemia and therapeutic monitoring in DA-positive cases. It is concluded that serially collected serum DA determinations complement blood cultures for improving detection and monitoring therapeutic response in patients at risk for invasive candidosis.
KW  - arabinitol
KW  - candidosis
KW  - diagnosis
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - serology
KW  - serum
KW  - USA
KW  - Blastodendrion arztii
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida lusitaniae
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Torulopsis
KW  - Pezizomycotina
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Blastodendrion
KW  - cancers
KW  - Candida guilliermondii
KW  - Candida krusei
KW  - candidiasis
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The treatment of aids and cancer in the third millennium.
AU  - Gallo, R. C.
AU  - Montagnier, J.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1995///
VL  - 99
IS  - Sup6A
SP  - 6S
EP  - 10S
SN  - 0002-9343
AD  - Gallo, R. C.: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 37 Convent Drive, MSC-4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962003772.  Publication Type: Journal Article.  Language: English. 
KW  - acquired immune deficiency syndrome
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - medical treatment
KW  - molecular biology
KW  - neoplasms
KW  - pathogenesis
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cancers
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Assessment of suitability & ease of performance of seven commercial assay systems for the detection of antibodies to HIV-1.
AU  - Sreedharan, A.
AU  - Jayshree, R. S.
AU  - Anita Desai
AU  - Hema Sridhar
AU  - Chandramuki, A.
AU  - Ravi, V.
JO  - Indian Journal of Medical Research
JF  - Indian Journal of Medical Research
Y1  - 1995///
VL  - 101
IS  - MAY
SP  - 179
EP  - 182
AD  - Sreedharan, A.: Department of Neurovirology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India.
N1  - Accession Number: 19952004926.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Tropical Diseases
N2  - In this study, the authors have evaluated the suitability and ease of performance of 7 HIV assays namely: Vironostika anti-HIV Uni-Form; Vironostika HIV MIXT; Elavia MIXT; Genelavia MIXT; Serodia-HIV; Immunocomb Bi-spot; and Test pack HIV-1 and 2 Abbott, for use in Indian laboratories. A panel of 41 blind coded Western blot confirmed sera were used for this purpose. Rapid assays like Immunocomb Bi-Spot, Serodia HIV and Test pack HIV-1/HIV-2 Abbott were found to be more suitable and easy to perform as compared to the ELISAs. Sensitivity of all the assays was excellent (100%). Specificity of Serodia HIV, Immunocomb Bi-spot, Test pack HIV-1 and 2 Abbott and Elavia MIXT were excellent (100%), while that of Vironostika MIXT and Vironostika anti-HIV Uni-Form was poor. Positive predictive value of the assays ranged from 64.5 to 100%. Negative predictive value of 6 of the assays was 100% and that of Vironostika anti-HIV Uni-Form was very poor.
KW  - antibodies
KW  - assessment
KW  - comparisons
KW  - detection
KW  - diagnosis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - performance
KW  - systems
KW  - Asia
KW  - India
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004926&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pathological lesions in HIV positive patients.
AU  - Santosh, V.
AU  - Shankar, S. K.
AU  - Das, S.
AU  - Pal, L.
AU  - Ravi, V.
AU  - Desai, A.
AU  - Sreedharan, A.
AU  - Khanna, N.
AU  - Chandramuki, A.
AU  - Satishchandra, P.
AU  - Swamy, H. S.
AU  - Nagaraj, D.
AU  - Gourie-Devi, M.
AU  - Das, B. S.
JO  - Indian Journal of Medical Research
JF  - Indian Journal of Medical Research
Y1  - 1995///
VL  - 101
IS  - APRIL
SP  - 134
EP  - 141
AD  - Santosh, V.: Department of Neuropathology, National Institute of Mental Health & Neuro Sciences, Bangalore, India.
N1  - Accession Number: 19952004853.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
KW  - central nervous system
KW  - encephalitis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lesions
KW  - meningitis
KW  - patients
KW  - postmortem examinations
KW  - tuberculosis
KW  - India
KW  - acanthamoeba
KW  - Toxoplasma
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - autopsy
KW  - CNS
KW  - encephalomyelitis
KW  - human immunodeficiency virus
KW  - postmortem inspections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004853&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Progress in AIDS vaccine development.
AU  - Johnston, M. I.
JO  - International Archives of Allergy and Immunology
JF  - International Archives of Allergy and Immunology
Y1  - 1995///
VL  - 108
IS  - 4
SP  - 313
EP  - 317
SN  - 1018-2438
AD  - Johnston, M. I.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7620, USA.
N1  - Accession Number: 19962004644.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
KW  - acquired immune deficiency syndrome
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - vaccine development
KW  - vaccines
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Parasitic infection in malnourished school children: effects on behaviour and EEG.
AU  - Levav, M.
AU  - Mirsky, A. F.
AU  - Schantz, P. M.
AU  - Casro, S.
AU  - Cruz, M. E.
JO  - Parasitology
JF  - Parasitology
Y1  - 1995///
VL  - 110
IS  - 1
SP  - 103
EP  - 111
SN  - 0031-1820
AD  - Levav, M.: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892-1366, USA.
N1  - Accession Number: 19950801866.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Protozoology; Helminthology; Tropical Diseases
N2  - A study of 194 children (9-13) from a mountain village in Ecuador who were infected with one or more species of intestinal helminth or protozoan parasite is described. In addition to parasite load, the assessment consisted of a battery of psychological and neuropsychological tests, an EEG examination, measures of iodine level, presence of goitre and level of nutrition. It was found that, in general, parasite infection, as measured at the baseline level, was not associated with cognitive impairment. The intensity of infection with Ascatis lumbricoides, however, was correlated with the level of verbal ability and with inhibition-control aspects of cognitive behaviour. Multivariate analysis with level of nutrition, EEG status and parasite burden showed a consistent main effect of the degree of nutrition on neuropsychological performance, particularly the language, problem solving and inhibition-control dimensions.
KW  - behaviour
KW  - children
KW  - electroencephalography
KW  - epidemiology
KW  - helminths
KW  - infection
KW  - malnutrition
KW  - neurophysiology
KW  - parasites
KW  - parasitoses
KW  - pathology
KW  - school children
KW  - Ecuador
KW  - South America
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - behavior
KW  - EEG
KW  - parasitic diseases
KW  - parasitic infestations
KW  - parasitic worms
KW  - parasitosis
KW  - school kids
KW  - schoolchildren
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801866&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Changes in lipophosphoglycan and gene expression associated with the development of Leishmania major in Phlebotomus papatasi.
AU  - Saraiva, E. M. B.
AU  - Pimenta, P. F. P.
AU  - Brodin, T. N.
AU  - Rowton, E.
AU  - Modi, G. B.
AU  - Sacks, D. L.
JO  - Parasitology
JF  - Parasitology
Y1  - 1995///
VL  - 111
IS  - 3
SP  - 275
EP  - 287
SN  - 0031-1820
AD  - Saraiva, E. M. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950808325.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Stage-specific molecular and morphogenic markers were used to follow the kinetics of appearance, number and position of metacyclic promastigotes developing during the course of Leishmania major infection in Phlebotomus papatasi. Expression of surface lipophosphoglycan (LPG) on transformed promastigotes was delayed until the appearance of nectomonad forms on day 3 and continued to be abundantly expressed by all promastigotes thereafter. An epitope associate with arabinose substitution of LPG side-chain oligosaccharides, identified by its differential expression by metacyclics in vitro, was detected on the surface of a low proportion of midgut promastigotes beginning on day 5 and on up to 60% of promastigotes on days 10 and 15. In contrast, 100% of the parasites egested from the mouthparts during forced feeding of 15 day infected flies stained strongly for this epitope. At each time-point, the surface expression of the modified LPG was restricted to morphologically distinguished metacyclic forms. Ultrastructural study of the metacyclic surface revealed an approximate 2-fold increase in the thickness of the surface coat compared to nectomonad forms, suggesting elongation of LPG as occurs during metacyclogenesis in vitro. A metacyclic-associated transcript (MAT-1), another marker identified by its differential expression in vitro, also showed selective expression by promastigotes in the fly, and was used in in situ hybridization studies to demonstrate the positioning of metacyclics in the anterior gut.
KW  - development
KW  - disease vectors
KW  - experimental infections
KW  - gene expression
KW  - intermediate hosts
KW  - laboratory animals
KW  - life history
KW  - lipophosphoglycans
KW  - molecular biology
KW  - molecular genetics
KW  - parasites
KW  - Diptera
KW  - Leishmania major
KW  - Phlebotominae
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Psychodidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - biochemical genetics
KW  - secondary hosts
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ribavirin as therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial.
AU  - Bisceglie, A. M. di
AU  - Conjeevaram, H. S.
AU  - Fried, M. W.
AU  - Sallie, R.
AU  - Park, Y.
AU  - Yurdaydin, C.
AU  - Swain, M.
AU  - Kleiner, D. E.
AU  - Mahaney, K.
AU  - Hoofnagle, J. H.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1995///
VL  - 123
IS  - 12
SP  - 897
EP  - 903
SN  - 0003-4819
AD  - Bisceglie, A. M. di: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19962005625.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 36791-04-5.  Subject Subsets: Public Health
N2  - The authors evaluated ribavirin as therapy for chronic hepatitis C in a randomized, double-blind, placebo-controlled study at a tertiary referral research hospital in Maryland, USA. 29 patients with chronic hepatitis C who received oral ribavirin (600 mg twice daily) for 12 months and 29 controls with chronic hepatitis C who received placebo for 12 months were studied. Effects of therapy were evaluated by measuring serum aminotransferase activity and hepatitis C virus (HCV) RNA levels before, during, and for 6 months after therapy and by histological examination of liver specimens before and at the end of treatment. Patients treated with ribavirin had a prompt decrease in serum aminotransferase activity (54% overall) compared with activity before treatment and activity in controls (5% decrease). Serum aminotransferase levels became normal or nearly normal in 10 patients treated with ribavirin (35% [95% CI, 18% to 54%]) but in no controls (0% [CI, 0% to 12%]). Aminotransferase activity remained normal in only 2 patients after ribavirin therapy was discontinued (7% [CI, 1% to 23%]). Serum HCV RNA activity did not change during or after therapy. Liver biopsy specimens showed a decrease in hepatic inflammation and necrosis among ribavirin-treated patients whose aminotransferase activity became normal. The authors conclude that ribavirin has beneficial effects on serum aminotransferase activity and histological findings in the liver in patients with chronic hepatitis C, but these effects are not accompanied by changes in HCV RNA levels and are not sustained when ribavirin therapy is discontinued. Thus, ribavirin alone for periods as long as 12 months is unlikely to be of value as therapy for chronic hepatitis C.
KW  - chronic infections
KW  - drug therapy
KW  - hepatitis C
KW  - human diseases
KW  - ribavirin
KW  - Maryland
KW  - North America
KW  - USA
KW  - hepatitis C virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - tribavirin
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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ER  - 

TY  - JOUR
T1  - Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta).
AU  - Lane, M. A.
AU  - Reznick, A. Z.
AU  - Tilmont, E. M.
AU  - Lanir, A.
AU  - Ball, S. S.
AU  - Read, V.
AU  - Ingram, D. K.
AU  - Cutler, R. G.
AU  - Roth, G. S.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1995///
VL  - 125
IS  - 6
SP  - 1600
EP  - 1610
SN  - 0022-3166
AD  - Lane, M. A.: Molecular Physiology and Genetics Section, Nathan Shock Laboratories, Gerontology Research Center, National Institute on Aging, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
N1  - Accession Number: 19951411232.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - The effects of aging and long-term (&gt;6.0 years) food restriction on several indices of bone growth and metabolism were studied in rhesus monkeys (Macaca mulatta). Food allotments for controls approximated free access consumption, whereas food-restricted monkeys received 30% less food on a body weight basis. Cross-sectional and longitudinal age effects on serum alkaline phosphatase paralleled those reported for man. Food restriction induced a significant delay in the developmental decline (to adult levels) in total alkaline phosphatase and significantly suppressed serum interleukin 6 concentrations, particularly in younger monkeys. Also, food restriction slowed skeletal growth, as reflected by shorter crown-rump length, and significantly reduced total body bone mineral content, but not bone mineral density, measured by dual energy X-ray absorptiometry. Analyses of serum parathyroid hormone, calcium phosphate and osteocalcin concentrations suggested that the effects on skeletal growth were not related to alterations in Ca in bone formation. These findings suggest that long-term food restriction delays skeletal development in male rhesus monkeys while allowing the development of a reduced but otherwise normal skeleton.
KW  - aging
KW  - bone density
KW  - bones
KW  - metabolism
KW  - mineral content
KW  - restricted feeding
KW  - macaca mulatta
KW  - monkeys
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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ER  - 

TY  - JOUR
T1  - Quantification and localization of phosphorylated myosin I isoforms in Acanthamoeba castellanii.
AU  - Baines, I. C.
AU  - Corigliano-Murphy, A.
AU  - Korn, E. D.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1995///
VL  - 130
IS  - 3
SP  - 591
EP  - 603
SN  - 0021-9525
AD  - Baines, I. C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19960803571.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 9064-37-3.  Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activities of the 3 myosin I isoforms in Acanthamoeba castellanii were significantly expressed only after phosphorylation of a single site in the myosin I heavy chain. Synthetic phosphorylated and unphosphorylated peptides corresponding to the phosphorylation site sequences, which differ for each myosin I isoform, were used to raise isoform-specific antibodies that recognized only the phosphorylated myosin I or the total myosin I isoform (phosphorylated and unphosphorylated), respectively. With these antisera, the amounts of total and phosphorylated isoform were quantified, the phosphomyosin I isoforms were localized and the compartmental distribution of the phosphomyosin isoforms was determined. Myosin IA, which was almost entirely in the actin-rich cortex, was 70-100% phosphorylated and particularly enriched under phagocytic cups. Myosins IB and IC were predominantly associated with plasma membranes and large vacuole membranes, where they were only 10-20% phosphorylated. Cytoplasmic myosins IB and IC, like cytoplasmic myosin IA, were mostly phosphorylated (60-100%). Phosphomyosin IB was concentrated in actively motile regions of the plasma membrane. More than 20-fold more phosphomyosin IC and 10-fold more F-actin were associated with the membranes of contracting contractile vacuoles (CV) than of filling CVs. The total amount of CV-associated myosin IC remained constant, suggesting that it is phosphorylated at the start of CV contraction. The data support previous proposals that phosphomyosin IA is involved in phagocytosis, phosphomyosin IB is involved in phagocytosis and pinocytosis, and phosphomyosin IC is involved in CV contraction.
KW  - actin
KW  - antibodies
KW  - cell membranes
KW  - cytochemistry
KW  - cytoplasm
KW  - isoenzymes
KW  - localization
KW  - myosins
KW  - parasites
KW  - peptides
KW  - phagocytosis
KW  - phosphorylation
KW  - plasma membranes
KW  - vacuoles
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cell membrane
KW  - isozymes
KW  - myosin
KW  - plasmalemma
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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ER  - 

TY  - GEN
T1  - Eosinophilic folliculitis associated with the acquired immunodeficiency syndrome responds well to permethrin.
AU  - Blauvelt, A.
AU  - Plott, R. T.
AU  - Spooner, K.
AU  - Stearn, B.
AU  - Davey, R. T.
AU  - Turner, M. L.
T2  - Archives of Dermatology
JO  - Archives of Dermatology
JF  - Archives of Dermatology
Y1  - 1995///
VL  - 131
IS  - 3
SP  - 360
EP  - 361
SN  - 0003-987X
AD  - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008269.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Registry Number: 52645-53-1. 
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - insecticides
KW  - permethrin
KW  - skin diseases
KW  - treatment
KW  - Demodex folliculorum
KW  - man
KW  - mites
KW  - Demodex
KW  - Demodicidae
KW  - Prostigmata
KW  - mites
KW  - Acari
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - AIDS
KW  - dermatoses
KW  - eosinophilic folliculitis
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - BK virus and a new type of JC virus excreted by HIV-1 positive patients in rural Tanzania.
AU  - Agostini, H. T.
AU  - Brubaker, G. R.
AU  - Shao, J.
AU  - Levin, A.
AU  - Ryschkewitsch, C. F.
AU  - Blattner, W. A.
AU  - Stoner, G. L.
JO  - Archives of Virology
JF  - Archives of Virology
Y1  - 1995///
VL  - 140
IS  - 11
SP  - 1919
EP  - 1934
SN  - 0304-8608
AD  - Agostini, H. T.: Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.
N1  - Accession Number: 19962002524.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Tropical Diseases
N2  - HIV-1 positive patients from villages near Shirati, Tanzania were examined for urinary excretion of the human polyomaviruses JC and BK using the polymerase chain reaction (PCR). BK virus (BKV) was detected in 11 of 23 individuals tested. The BKV DNA sequences were all closely related to prototype Gardner strain and BKV (DUN). In contrast, a new type of JCV, termed Type 3 [or JCV (Shi)], was identified in 7 of these same 23 individuals by comparison with Type 1 and Type 2 sequences of the VP1/intergenic/T antigen region of USA, European and Asian strains. This suggests that JCV and BKV, although closely related, have different evolutionary histories within the African population. The 6 BKV regulatory regions amplified all showed the archetypal configuration. However, two of the 7 JCV regulatory regions showed rearrangements: a small deletion and an inverted repeat. JCV causes a fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML), in about 5% of AIDS patients in Europe and the USA, but only one case has been reported in Africa. The authors' results suggest that this rarity of PML is not due to the absence of JCV in the African population.
KW  - disease prevalence
KW  - epidemiology
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infections
KW  - rural areas
KW  - rural communities
KW  - Africa
KW  - Tanzania
KW  - BK polyomavirus
KW  - JC polyomavirus
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - jc virus
KW  - polyomavirus hominis 1
KW  - Tanganyika
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Does weight loss from middle age to old age explain the inverse weight mortality relation in old age?
AU  - Losonczy, K. G.
AU  - Harris, T. B.
AU  - Cornoni-Huntley, J.
AU  - Simonsick, E. M.
AU  - Wallace, R. B.
AU  - Cook, N. R.
AU  - Ostfeld, A. M.
AU  - Blazer, D. G.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1995///
VL  - 141
IS  - 4
SP  - 312
EP  - 321
SN  - 0002-9262
AD  - Losonczy, K. G.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892-9205, USA.
N1  - Accession Number: 19951404930.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - Body mass index at middle age, body mass index in old age, and weight change between 50 years and old age were examined in relation to mortality in old age. The study population from the Established Populations for Epidemiologic Studies of the Elderly consisted of 6387 white subjects 70 years or older who experienced 2650 deaths during the period 1982-1987. Mortality risk was highest for persons in the heaviest quintile of body mass index at age 50 (men, relative risk (RR) 1.33, 95% confidence interval (CI) 1.13-1.57; women, RR 1.31, 95% CI 1.12-1.53) compared with persons in the middle quintile. This pattern was reversed for body mass index in old age, the persons in the lowest quintile having the highest mortality risk (men, RR 1.40, 95% CI 1.19-1.65; women, RR 1.38, 95% CI 1.17-1.63) relative to persons in the middle quintile. This reversal was explained in part by weight change. Compared with persons with stable weight, those who lost 10% or more body weight between age 50 and old age had the highest risk of mortality (men, RR 1.69, 95% CI 1.45-1.97; women, RR 1.62, 95% CI 1.38-1.90). Exclusion of participants who lost 10% or more of their weight and adjustment for health status eliminated the higher risk of death associated with low weight. The inverse association of weight and mortality in old age appears to reflect illness related weight loss from heavier weight in middle age. Weight history may be critical to understanding weight and mortality relations in old age.
KW  - aging
KW  - body weight
KW  - middle age
KW  - mortality
KW  - old age
KW  - weight losses
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - death rate
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nitrous oxide and spontaneous abortion in female dental assistants.
AU  - Rowland, A. S.
AU  - Baird, D. D.
AU  - Shore, D. L.
AU  - Weinberg, C. R.
AU  - Savitz, D. A.
AU  - Wilcox, A. J.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1995///
VL  - 141
IS  - 6
SP  - 531
EP  - 538
SN  - 0002-9262
AD  - Rowland, A. S.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19952003988.  Publication Type: Journal Article.  Language: English.  Registry Number: 10024-97-2.  Subject Subsets: Public Health
N2  - Questionnaires were sent to 7000 dental assistants aged 18-39 years who were registered in California in 1987; 4,856 (69%) responded. Analysis was based on 1,465 respondents whose most recent pregnancy was conceived while working full time. Women were asked how many hours a week they worked with nitrous oxide during this pregnancy and whether the excess gas was scavenged (vented). Relative risk of spontaneous abortion (through week 20) was calculated using a person-week model. This allowed women with current pregnancies (13%) or induced abortions (10%) to be included for appropriate time periods of risk. A total of 101 pregnancies (7%) ended as spontaneous abortions. An elevation in risk of spontaneous abortion was seen among women who worked with nitrous oxide for 3 or more hours per week in offices not using scavenging equipment (relative risk = 2.6, 95% confidence interval 1.3-5.0, adjusted for age, smoking, and number of amalgams prepared per week), but not among those using nitrous oxide in offices with scavenging equipment. This relation changed little when analyses were restricted to confirmed pregnancies or examined for several types of potential bias. Scavenging equipment appears to be important in protecting the reproductive health of women working with nitrous oxide.
KW  - abortion
KW  - air pollutants
KW  - dentistry
KW  - nitrous oxide
KW  - occupational hazards
KW  - occupations
KW  - spontaneous abortion
KW  - women
KW  - California
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - dental assistants
KW  - miscarriage
KW  - United States of America
KW  - Occupational Health and Safety (VV900) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Prognostic factors for all-cause mortality among hemophiliacs infected with human immunodeficiency virus.
AU  - Diamondstone, L. S.
AU  - Blakley, S. A.
AU  - Rice, J. C.
AU  - Clark, R. A.
AU  - Goedert, J. J.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1995///
VL  - 142
IS  - 3
SP  - 304
EP  - 313
SN  - 0002-9262
AD  - Diamondstone, L. S.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19962007074.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
KW  - acquired immune deficiency syndrome
KW  - haemophilia
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mortality
KW  - prognosis
KW  - risk groups
KW  - USA
KW  - hepatitis c virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - death rate
KW  - hemophilia
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Colon cancer and serum vitamin D metabolite levels 10-17 years prior to diagnosis.
AU  - Braun, M. M.
AU  - Helzlsouer, K. J.
AU  - Hollis, B. W.
AU  - Comstock, G. W.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1995///
VL  - 142
IS  - 6
SP  - 608
EP  - 611
SN  - 0002-9262
AD  - Braun, M. M.: Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19961407600.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 32222-06-3, 1406-16-2.  Subject Subsets: Human Nutrition
N2  - This study examines the hypothesis that low serum levels of vitamin D metabolites are associated with an increased risk for colon cancer. From August through November 1974, 20 305 residents of Washington County, Maryland, USA donated blood for storage at -70°C in a serum bank. Colon cancer was subsequently diagnosed among 57 of these residents during 1984-1991. Controls had donated blood in 1974 and remained free of colon cancer through the date of diagnosis of the case. 2 controls were matched to each case on age (±1 year), race, sex and date of blood draw (±1 month). Mean 25-hydroxyvitamin D levels were 23.6 and 23.2 ng/ml, and mean calcitriol levels were 34.7 and 34.6 pg/ml, in cases and controls, respectively. Analysis by quintile of serum level similarly found that none of the 95% confidence intervals of the odds ratios excluded unity, and a dose-response effect was not observed. The data provide no strong support for the hypothesis that vitamin D metabolite levels affect the subsequent risk for colon cancer.
KW  - blood
KW  - calcitriol
KW  - colon
KW  - neoplasms
KW  - vitamin D
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - 1,25-dihydroxycholecalciferol
KW  - 1,25-dihydroxyvitamin D
KW  - cancers
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of secular trends in CD4+ lymphocyte loss among human immunodeficiency virus type 1 (HIV-1)-infected men with known dates of seroconversion.
AU  - O'Brien, T. R.
AU  - Hoover, D. R.
AU  - Rosenberg, P. S.
AU  - Chen, B.
AU  - Detels, R.
AU  - Kingsley, L. A.
AU  - Phair, J.
AU  - Saah, A. J.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1995///
VL  - 142
IS  - 6
SP  - 636
EP  - 642
SN  - 0002-9262
AD  - O'Brien, T. R.: Epidemiology and Biostatistics Program, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Rockville, MD 20852, USA.
N1  - Accession Number: 19962006265.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
KW  - disease course
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - men
KW  - seroconversion
KW  - serology
KW  - t lymphocytes
KW  - trends
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006265&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica.
AU  - Krämer, A.
AU  - Maloney, E. M.
AU  - Morgan, O. S. C.
AU  - Rodgers-Johnson, P.
AU  - Manns, A.
AU  - Murphy, E. L.
AU  - Larsen, S.
AU  - Cranston, B.
AU  - Murphy, J.
AU  - Benichou, J.
AU  - Blattner, W. A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1995///
VL  - 142
IS  - 11
SP  - 1212
EP  - 1220
SN  - 0002-9262
AD  - Krämer, A.: Viral Epidemiology Branch, National Cancer Institute, EPN Room 434, Rockville, MD, USA.
N1  - Accession Number: 19962007347.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Tropical Diseases
N2  - Human T-cell lymphotropic virus type I (HTLV-I) has been aetiologically associated with a neurological syndrome called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) as well as with adult T-cell leukaemia/lymphoma. This study sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I infection and cofactors associated with this disease among infected individuals. Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with other neurological diseases were enrolled in a retrospective study. A second control group was composed of HTLV-I-seropositive, asymptomatic carriers in Jamaica, ascertained in a separate study conducted in 1988. Although HTLV-I seropositivity was not a component of the case definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive compared with 2 (4.0%) of the controls with other neurological diseases. Given HTLV-I seropositivity, one cofactor associated with the risk of HAM/TSP was young age at initial heterosexual intercourse (odds ratio = 4.00, 95% confidence interval 1.29-12.46 for individuals aged ≤15; odds ratio = 4.26, 95% confidence interval 1.41-12.90 for individuals aged 16-17 years at initial intercourse). Among individuals who reported this early age at initial sexual intercourse, an increased risk of HAM/TSP was associated with having reported more than 5 lifetime sexual partners (odds ratio = 2.88, 95% confidence interval 0.90-8.70). Neither an early age at initial sexual intercourse nor the number of lifetime sexual partners was a risk factor for adult T-cell leukaemia/lymphoma. These data support the hypothesis that HAM/TSP is associated with sexually acquired HTLV-I infection, whereas adult T-cell leukaemia/lymphoma is not.
KW  - epidemiology
KW  - human diseases
KW  - infections
KW  - myelopathy
KW  - risk factors
KW  - sexual partners
KW  - sexually transmitted diseases
KW  - viral diseases
KW  - Caribbean
KW  - Jamaica
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - man
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - Threshold Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - sexually transmitted infections
KW  - STDs
KW  - venereal diseases
KW  - viral infections
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007347&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of IL-12 in HIV disease/AIDS.
AU  - Chougnet, C.
AU  - Clerici, M.
AU  - Shearer, G. M.
JO  - Research in Immunology
JF  - Research in Immunology
Y1  - 1995///
VL  - 146
IS  - 7-8
SP  - 615
EP  - 619
SN  - 0923-2494
AD  - Chougnet, C.: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962008883.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
KW  - acquired immune deficiency syndrome
KW  - cytokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunological deficiency
KW  - immunology
KW  - interleukins
KW  - pathogenesis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune deficiency
KW  - immunodeficiency
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008883&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of IL12 induction of cell-mediated immunity to Toxoplasma gondii.
AU  - Scharton-Kersten, T.
AU  - Denkers, E. Y.
AU  - Gazzinelli, R.
AU  - Sher, A.
JO  - Research in Immunology
JF  - Research in Immunology
Y1  - 1995///
VL  - 146
IS  - 7/8
SP  - 539
EP  - 545
SN  - 0923-2494
AD  - Scharton-Kersten, T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960805348.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - The role of interleukin (IL)-12 in establishing the host immune response to Toxoplasma gondii is reviewed, with reference to interferon (IFN)-γ-dependent cell mediated immunity, the role of IL-12 in the initiation of the innate IFN-γ response, the role of IL-12 in adaptive immunity, and control of IL-12 function during infection. Studies have shown that T. gondii is a potent, IFN-γ-independent stimulus of controlled IL-12 production and, as a result, an effective stimulator of protective cell-mediated immunity.
KW  - cell mediated immunity
KW  - immune response
KW  - immunology
KW  - interferon
KW  - interleukin 12
KW  - parasites
KW  - reviews
KW  - toxoplasmosis
KW  - protozoa
KW  - Toxoplasma gondii
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cellular immunity
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805348&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL12 as an adjuvant for vaccines designed to prevent infection and immunopathology by schistosomes.
AU  - Wynn, T. A.
AU  - Sher, A.
JO  - Research in Immunology
JF  - Research in Immunology
Y1  - 1995///
VL  - 146
IS  - 7/8
SP  - 582
EP  - 590
SN  - 0923-2494
AD  - Wynn, T. A.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960805354.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Registry Number: 9008-11-1.  Subject Subsets: Helminthology
N2  - The potential of interleukin (IL)-12 as an adjuvant for vaccines designed to reduce infection and prevent the pathology associated with schistosome infection is reviewed, with reference to the enhancement of vaccine-induced immunity to Schistosoma mansoni by IL-12, the effects of IL-12 in other helminth infections, the role of endogenous and exogenous IL-12 in the regulation of schistosome egg granuloma formation, the role of interferon-γ in IL-12-mediated immunoregulation, the partial suppression of established Th2 responses and marked decrease of secondary granulomatous inflammation by IL-12, and the adjuvant activity of IL-12 in an anti-pathology vaccine for schistosomiasis. The data show that IL-12 can upregulate protective immunity against schistosomes in the attenuated vaccine model and can act as an adjuvant suppressing both granuloma formation and fibrosis induced by natural infection.
KW  - adjuvants
KW  - animal models
KW  - attenuation
KW  - fibrosis
KW  - granuloma
KW  - helminths
KW  - human diseases
KW  - immunity
KW  - immunization
KW  - inflammation
KW  - interferon
KW  - interleukin 12
KW  - parasites
KW  - pathology
KW  - reviews
KW  - schistosomiasis
KW  - T lymphocytes
KW  - vaccine development
KW  - vaccines
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - bilharzia
KW  - bilharziasis
KW  - immune sensitization
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805354&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis.
AU  - Ognibene, F. P.
AU  - Shelhamer, J. H.
AU  - Hoffman, G. S.
AU  - Kerr, G. S.
AU  - Reda, D.
AU  - Fauci, A. S.
AU  - Leavitt, R. Y.
JO  - American Journal of Respiratory and Critical Care Medicine
JF  - American Journal of Respiratory and Critical Care Medicine
Y1  - 1995///
VL  - 151
IS  - 3 Part 1
SP  - 795
EP  - 799
SN  - 1073-449X
AD  - Ognibene, F. P.: Department of Critical Care Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1662, USA.
N1  - Accession Number: 19961200244.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A retrospective analysis of all patients with a diagnosis of Wegener's granulomatosis and P. carinii pneumonia at the National Institute of Allergy and Infectious Diseases, Maryland, USA, was performed. The chart review focused on clinical, laboratory and roentgenological evidence of P. carinii pneumonia. 11 cases of P. carinii pneumonia were diagnosed in 180 patients with Wegener's granulomatosis, giving an overall incidence of approx. 6%. All patients developed P. carinii pneumonia either during the initial course of treatment or during therapy for recurrent Wegener's granulomatosis. All patients were receiving daily glucocorticoids and a 2nd immunosuppressive therapy. Lymphocytopenia was noted in all patients, with a mean ± SEM total lymphocyte count of 303±69 cells/µl. All patients tested (10 of 11) were seronegative for HIV infection. Eight patients presented with worsening chest roentgenograms compared with baseline, while 3 presented with normal chest roentgenograms. It is concluded that P. carinii is a common opportunistic pathogen in patients with Wegener's granulomatosis receiving immunosuppressive therapy. Therapeutic immunosuppression (daily glucocorticoids and immunosuppressive agents) and the resultant lymphocytopenia, as well as the lymphocyte and monocyte functional abnormalities caused by glucocorticoids, may be the most likely factors predisposing to P. carinii pneumonia in patients with Wegener's granulomatosis. It is recommended that all patients with Wegener's granulomatosis be given chemoprophylaxis against P. carinii while they are receiving daily glucocorticoids and that clinicians should evaluate these patients for P. carinii if there is even a minor clinical or roentgenographic change in their status.
KW  - acquired immune deficiency syndrome
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunosuppression
KW  - infections
KW  - lungs
KW  - mycoses
KW  - opportunistic infections
KW  - pneumocystosis
KW  - pneumonia
KW  - predisposition
KW  - Maryland
KW  - USA
KW  - fungi
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - fungus
KW  - United States of America
KW  - Wegener's granulomatosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200244&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression.
AU  - Berenguer, J.
AU  - Allende, M. C.
AU  - Lee, J. W.
AU  - Garrett, K.
AU  - Lyman, C.
AU  - Ali, N. M.
AU  - Bacher, J.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - American Journal of Respiratory and Critical Care Medicine
JF  - American Journal of Respiratory and Critical Care Medicine
Y1  - 1995///
VL  - 152
IS  - 3
SP  - 1079
EP  - 1086
SN  - 1073-449X
AD  - Berenguer, J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200016.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 59865-13-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - To compare the pathogenesis of aspergillosis in patients with chemotherapy-induced granulocytopenia for neoplastic disorders and those receiving cyclosporin A plus corticosteroids for prevention and treatment of organ transplant rejection, and to further characterize the role of cyclosporin A in development of pulmonary aspergillosis, the patterns of infection and inflammation in 2 clinically applicable rabbit models of invasive pulmonary aspergillosis were studied. There were striking differences in the patterns of infection and inflammation of invasive pulmonary Aspergillus fumigatus infection according to the type of underlying immune defect. Among rabbits challenged with the same intratracheal inoculum, there was a 100% mortality for invasive pulmonary aspergillosis in profoundly granulocytopenic rabbits in comparison with a 100% survival in rabbits immunosuppressed with cyclosporin A plus methylprednisolone (CsA + MP). Lesions of pulmonary aspergillosis in granulocytopenic rabbits consisted predominantly of coagulative necrosis, intraalveolar haemorrhage and scant mononuclear inflammatory infiltrate. By comparison, pulmonary foci in rabbits immunosuppressed by CsA + MP consisted mainly of neutrophilic and monocytic infiltrates, inflammatory necrosis and scant intraalveolar haemorrhage. There was extensive infiltration by hyphae with angioinvasion in granulocytopenic rabbits, while conidia in various stages of germination predominated in CsA + MP-treated animals in which there was a paucity of hyphae or angioinvasion. Extrapulmonary disease predominated in granulocytopenic rabbits. Methylprednisolone was the major immunosuppressive drug in rabbits treated with CsA + MP. Cyclosporin A alone did not increase the progression of pulmonary aspergillosis and did so only when used chronically with methylprednisolone.
KW  - aspergillosis
KW  - ciclosporin
KW  - corticoids
KW  - experimental infections
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - opportunistic infections
KW  - pathogenesis
KW  - predisposition
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - corticosteroids
KW  - cyclosporin
KW  - fungus
KW  - granulocytopenia
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule.
AU  - Takeshita, T.
AU  - Takahashi, H.
AU  - Kozlowski, S.
AU  - Ahlers, J. D.
AU  - Pendleton, C. D.
AU  - Moore, R. L.
AU  - Nakagawa, Y.
AU  - Yokomuro, K.
AU  - Fox, B. S.
AU  - Margulies, D. H.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 154
IS  - 4
SP  - 1973
EP  - 1986
SN  - 0022-1767
AD  - Takeshita, T.: Correspondence address: J. A. Berzofsky, Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Building 10, Room 6B-12, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009467.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
KW  - binding
KW  - conformation
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - major histocompatibility complex
KW  - peptides
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - body conformation
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009467&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines.
AU  - Kinter, A. L.
AU  - Poli, G.
AU  - Fox, L.
AU  - Hardy, E.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 154
IS  - 5
SP  - 2448
EP  - 2459
SN  - 0022-1767
AD  - Kinter, A. L.: Building 10A, Room 6A33A, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009469.  Publication Type: Journal Article.  Language: English.  Number of References: 74 ref.
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interleukins
KW  - phagocytes
KW  - replication
KW  - T lymphocytes
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009469&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons.
AU  - Blauvelt, A.
AU  - Clerici, M.
AU  - Lucey, D. R.
AU  - Steinberg, S. M.
AU  - Yarchoan, R.
AU  - Walker, R.
AU  - Shearer, G. M.
AU  - Katz, S. I.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 154
IS  - 7
SP  - 3506
EP  - 3515
SN  - 0022-1767
AD  - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Building 10/Room 12N238, 10 Center Dr., MSC 1908, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009056.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - monocytes
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Langerhans cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009056&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice.
AU  - Samaniego, F.
AU  - Markham, P. D.
AU  - Gallo, R. C.
AU  - Ensoli, B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 154
IS  - 7
SP  - 3582
EP  - 3592
SN  - 0022-1767
AD  - Samaniego, F.: Correspondence address: B. Ensoli, Laboratory of Tumor Cell Biology, Bldg. 37, Rm. 6A09, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952009058.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - pathogenesis
KW  - man
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009058&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vaccination routes that fail to elicit protective immunity against Schistosoma mansoni induce the production of TGF-β, which down-regulates macrophage antiparasitic activity.
AU  - Williams, M. E.
AU  - Casper, P.
AU  - Oswald, I.
AU  - Sharma, H. K.
AU  - Pankewycz, O.
AU  - Sher, A.
AU  - James, S. L.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 154
IS  - 9
SP  - 4693
EP  - 4700
SN  - 0022-1767
AD  - Williams, M. E.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007714.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 76057-06-2.  Subject Subsets: Tropical Diseases; Helminthology
N2  - C57BL/6 mice immunized intradermally (i.d.) with bacillus Calmette Guerin (BCG) plus killed skin-stage schistosomula are protected against subsequent infection with Schistosoma mansoni, whereas immunization by i.v. or i.m. routes is not protective. Moreover, previous immunization via the nonprotective i.v. route interfered with the ability to subsequently induce protection by i.d. vaccination, suggesting that inhibitory responses are invoked. Given the evidence that activated macrophages (Mφ) play a role as effector cells in protection against schistosomiasis, the authors investigated the ability of spleen cells from protected and nonprotected immunized mice to produce Mφ activating and deactivating cytokines. Exposure to supernatant fluids (SNs) from Ag stimulated spleen cells of i.d., but not i.v. or i.m., immunized mice activated inflammatory Mφ for in vitro killing of schistosome larvae, through a mechanism dependent on both IFNγ and TNF-α. No evidence was observed for the preferential induction of the Mφ activating Th1 cytokines IFN-γ and IL-2 in i.d. immunized mice, nor did spleen cells from nonprotected animals produce higher levels of the Th2 associated cytokines IL-4 and IL-10, which are known to prevent Mφ activation. TGF-β was, however, detected in SNs from unprotected mice. Moreover, the Mφ inhibitory activity detected in these SNs was heat stable and neutralized by anti-TGF-β Abs, suggesting that production of transforming growth factor (TGF-β) is at least partially responsible for the failure of i.m. and i.v. immunized mice to develop immunity to S. mansoni. Thus, the induction of down-regulatory cytokines may be an important factor limiting the efficacy of certain vaccination protocols.
KW  - disease models
KW  - experimental infections
KW  - failure
KW  - helminths
KW  - human diseases
KW  - immunity
KW  - immunization
KW  - inactivated vaccines
KW  - laboratory animals
KW  - macrophages
KW  - parasites
KW  - schistosomiasis
KW  - transforming growth factor
KW  - vaccines
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immune sensitization
KW  - killed vaccines
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007714&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper cytokine expression, IgE production, and tissue eosinophilia.
AU  - Wynn, T. A.
AU  - Jankovic, D.
AU  - Hieny, S.
AU  - Cheever, A. W.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 154
IS  - 9
SP  - 4701
EP  - 4709
SN  - 0022-1767
AD  - Wynn, T. A.: Immunology and Cell Biology, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952007401.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 37341-29-0.  Subject Subsets: Tropical Diseases; Helminthology
N2  - Vaccination of mice with radiation-attenuated cercariae of Schistosoma mansoni results in a highly significant but partial protection against challenge infection. This immunity is dependent on CD4+ T cells, and because of its suppression by anti-interferon-γ (IFN-γ), appears to be caused by a Th1 response. Nevertheless, both Th1 and Th2 lymphokines are expressed in vaccinated and challenged mice, and the authors hypothesized that the expression of the latter group of down-regulatory cytokines may be responsible for the failure to obtain complete protection. Because interleukin-12 (IL-12) is a key cytokine that suppresses Th2-like responses, the authors asked whether IL-12 could increase vaccine-induced immunity to S. mansoni. Indeed, administration of IL-12 significantly reduced worm burdens following a challenge infection. IL-12-treated animals displayed a marked increase in pulmonary IFN-γ and IL-12 p40 mRNA expression, while levels of IL-4, IL-5, and IL-13 were suppressed significantly during the period of vaccination. A marked decrease in serum IgE and tissue eosinophilia, two responses regulated by Th2 cytokines, was also observed. Surprisingly, IL-12 treated/vaccinated mice failed to demonstrate a significant increase in IFN-γ, TNF-α, or nitric oxide synthase mRNA at the time of challenge infection when compared with vaccinated controls, but did, however, display significantly suppressed Th2 cytokine mRNA production. Together, these data demonstrate that exogenous IL-12 regulates Th1/Th2 responses during immunization with irradiated cercariae, and suggest that this cytokine may be used to increase vaccine-induced immunity to S. mansoni.
KW  - antibodies
KW  - cytokines
KW  - disease models
KW  - eosinophilia
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - immune response
KW  - immunization
KW  - immunotherapy
KW  - interleukin 12
KW  - interleukins
KW  - laboratory animals
KW  - parasites
KW  - schistosomiasis
KW  - T lymphocytes
KW  - vaccines
KW  - man
KW  - mice
KW  - Schistosoma mansoni
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007401&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ.
AU  - Zhou Ping
AU  - Sieve, M. C.
AU  - Bennett, J.
AU  - Kwon-Chung, K. J.
AU  - Tewari, R. P.
AU  - Gazzinelli, R. T.
AU  - Sher, A.
AU  - Seder, R. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 155
IS  - 2
SP  - 785
EP  - 795
SN  - 0022-1767
AD  - Zhou Ping: Lymphokine Regulation Unit and Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200534.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9008-11-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - The regulation of cytokine induction in mice infected with H. capsulatum and the effects of IL-12 in the course of infection were investigated. Mice infected with H. capsulatum and treated with neutralizing antibodies (Ab) to IFN-γ, TNF-γ or IL-2 experienced accelerated mortality, indicating that endogenous production of these cytokines has an important role in response to infection. Mice treated with IL-12 or a neutralizing Ab to IL-4 at the initiation of infection had substantially diminished mortality. Mice infected and treated with IL-12 showed a 2- to 3-fold increase in the amount of IFN-γ following in vitro stimulation with specific H. capsulatum antigens (Ag) compared with control infected mice. The protective effect of IL-12 was abrogated if a neutralizing Ab to IFN-γ was given at the same time, demonstrating that the role of IL-2 in protection was mediated by IFN-γ. Infected mice treated with IL-12 had a several-fold decrease in colony counts of H. capsulatum in spleen cells after 5 d of infection compared with control animals. Spleen cells from infected animals treated with IL-12 showed a striking decrease in their proliferative response to mitogen or H. capsulatum Ag. Responses were restored by addition of inhibitors of IFN-γ or nitric oxide to the in vitro cultures. It is suggested that IL-12 may be useful in immunological intervention against H. capsulatum.
KW  - cytokines
KW  - experimental infections
KW  - histoplasmosis
KW  - immune response
KW  - immunology
KW  - infections
KW  - interferon
KW  - interleukins
KW  - Histoplasma capsulatum
KW  - mice
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Histoplasma
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Ajellomyces capsulatus
KW  - fungus
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies.
AU  - Garraud, O.
AU  - Nkenfou, C.
AU  - Bradley, J. E.
AU  - Perler, F. B.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1995///
VL  - 155
IS  - 3
SP  - 1316
EP  - 1325
SN  - 0022-1767
AD  - Garraud, O.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960802284.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4, 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Filarial infection is characterized by an immune response associated with the production of antigen (Ag)-specific IgG4 and IgE and interleukin (IL)-4 and IL-5. To identify filarial Ags capable of inducing such responses and to analyse the role Ags play in sustaining it, 24 recombinant filarial parasite proteins were screened for their ability to be recognized by sera from 67 individuals with tissue-invasive filarial (Loa loa or Onchocerca volvulus) infections. Among the recombinant proteins recognized by IgG4 or IgE antibodies in 25% of the sera or more, 2 were selected on the basis of their ability to elicit polyclonal and Ag-specific IgE/IgG4 antibodies in vitro. Ov27 (analogous to Ov7/cystatin, a cysteine proteinase inhibitor) and OvD5B (analogous to Ov33, an aspartyl proteinase inhibitor) induced both a polyclonal and Ag-specific IgE/IgG4 response that was blocked by neutralizing antibodies to IL-4 and IL-3 or by soluble IL-4 receptors. Recombinant human interferon (IFN)-γ and IL-12 also led to a decrease in the production of polyclonal and Ag-specific IgE/IgG4 antibodies. In addition, these 2 recombinant proteins preferentially stimulated the secretion of IL-4, IL-5 and IL-10 (in contrast to IFN-γ). The data suggest that certain epitopes on filarial Ags preferentially elicit a Th2-type response and provide an in vitro model for studying the mechanisms underlying this process.
KW  - antibodies
KW  - antigens
KW  - enzyme inhibitors
KW  - epitopes
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - IgG
KW  - immune response
KW  - immunoglobulins
KW  - in vitro
KW  - infections
KW  - interferon
KW  - interleukin 4
KW  - interleukin 5
KW  - interleukins
KW  - onchocerciasis
KW  - parasites
KW  - proteins
KW  - recombinant proteins
KW  - T lymphocytes
KW  - Loa loa
KW  - man
KW  - Onchocerca volvulus
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Onchocerca
KW  - African eyeworm
KW  - antigenic determinants
KW  - antigenicity
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802284&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mycobacterium tuberculosis infection in pregnant and nonpregnant women infected with HIV in the Women and Infants Transmission Study.
AU  - Mofenson, L. M.
AU  - Rodriguez, E. M.
AU  - Hershow, R.
AU  - Fox, H. E.
AU  - Landesman, S.
AU  - Tuomala, R.
AU  - Diaz, C.
AU  - Daniels, E.
AU  - Brambilla, D.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1995///
VL  - 155
IS  - 10
SP  - 1066
EP  - 1072
SN  - 0003-9926
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Room 4B11, 6100 Executive Blvd, MSC 7510, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19952008263.  Publication Type: Journal Article.  Corporate Author: USA, Women and Infants Transmission Study Group Language: English.  Number of References: 31 ref.
KW  - acquired immune deficiency syndrome
KW  - clinical aspects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - opportunistic infections
KW  - pregnancy
KW  - tuberculosis
KW  - women
KW  - USA
KW  - man
KW  - Mycobacterium tuberculosis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - bacterium
KW  - clinical picture
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008263&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Further analysis of the CAP59 locus of Cryptococcus neoformans: structure defined by forced expression and description of a new ribosomal protein-encoding gene.
AU  - Chang, Y. C.
AU  - Wickes, B. L.
AU  - Kwon-Chung, K. J.
JO  - Gene
JF  - Gene
Y1  - 1995///
VL  - 167
IS  - 1-2
SP  - 179
EP  - 183
SN  - 0378-1119
AD  - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961202270.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - To dissect the functional region of CAP59, a C. neoformans gene necessary for capsule formation, it was placed under control of the CnGAL7 promoter (pGAL7). Among the several pGAL7::CAP59 fusion constructs, only the one containing the entire open reading frame of CAP59 was able to complement the acapsular phenotype under galactose induction. A missense mutation in the coding region abolished complementation by the fusion construct. The CAP59 locus was contiguous to a convergently transcribed L27 ribosomal protein-encoding gene (CL27). The distance between the cDNA ends of these 2 genes was only 25 bp. CL27 had 2 introns near its N terminus. The translated CL27 protein was 183 amino acids (aa) in length with an estimated molecular mass of 20 kDa, and the first 34 aa at the N terminus could be a targeting peptide for mitochondria. A high degree of restriction fragment length polymorphism was detected in the DNA sequence containing CAP59 and CL27.
KW  - gene expression
KW  - genes
KW  - genetics
KW  - virulence
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - capsule
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Summary of the 29th United States-Japan joint conference on cholera and related diarrheal diseases.
AU  - Lang, D. R.
AU  - Guerrant, R. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 1
SP  - 8
EP  - 12
SN  - 0022-1899
AD  - Lang, D. R.: Enteric Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-7630, USA.
N1  - Accession Number: 19952004732.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 16 ref. Subject Subsets: Public Health
N2  - The 29th Joint Conference on Cholera and Related Diarrheal Diseases was held in Monterey, California, USA on 1-3 December 1993. This international meeting provided a forum to discuss ongoing research and to promote collaborations between USA and Japanese investigators. More than 130 persons representing 13 countries attended.
KW  - cholera
KW  - diarrhoea
KW  - diseases
KW  - human diseases
KW  - Asia
KW  - Japan
KW  - North America
KW  - USA
KW  - man
KW  - Vibrio cholerae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - America
KW  - North America
KW  - bacterium
KW  - diarrhea
KW  - scouring
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004732&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.
AU  - Secchiero, P.
AU  - Carrigan, D. R.
AU  - Asano, Y.
AU  - Benedetti, L.
AU  - Crowley, R. W.
AU  - Komaroff, A. L.
AU  - Gallo, R. C.
AU  - Lusso, P.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 2
SP  - 273
EP  - 280
SN  - 0022-1899
AD  - Secchiero, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg. 37, Room 6A11, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952002225.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Subject Subsets: Public Health
N2  - A sensitive and specific polymerase chain reaction method for the detection of human herpesvirus 6 (HHV-6) DNA in serum or plasma has been developed. In total, 157 human serum or plasma samples were studied. HHV-6 DNA was detected in 6 (85.7%) of 7 children with exanthem subitum, 3 (23.1%) of the 13 bone marrow transplant (BMT) recipients, 4 (22.2%) of 18 human immunodeficiency virus (HIV) infected patients, 1 (2.6%) of 39 patients with chronic fatigue syndrome, and none of 37 healthy adults. In the HHV-6 positive BMT recipients, HHV-6 plasma DNA was transiently detected during episodes of fever and respiratory infection. In children with exanthem subitum and in 1 HIV infected patient, the HHV-6 strains were characterized as variant B, whereas variant A was detected in all other patients. Detection of viral DNA in serum or plasma is a marker of active infection that can be used to investigate the role of HHV-6 in human disease.
KW  - children
KW  - detection
KW  - diagnosis
KW  - human diseases
KW  - infections
KW  - polymerase chain reaction
KW  - North America
KW  - USA
KW  - human herpesvirus 6
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - PCR
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunity to onchocerciasis: putative immune persons produce a Th1-like response to Onchocerca volvulus.
AU  - Elson, L. H.
AU  - Calvopiña H., M.
AU  - Paredes Y., W.
AU  - Araujo N., E.
AU  - Bradley, J. E.
AU  - Guderian, R. H.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 3
SP  - 652
EP  - 658
SN  - 0022-1899
AD  - Elson, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950804735.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 9008-11-1, 130068-27-8.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Immunity to Onchocerca volvulus infection is suggested by the presence of putatively immune (PI) subjects in a region of Ecuador in which O. volvulus is endemic. PI subjects were identified by traditional diagnostic methods combined with a polymerase chain reaction-based assay for O. volvulus DNA in skin snips. Responses of peripheral blood mononuclear cells (PBMC) from the PI group (n = 16) were compared with those of people with active infection (microfiladermic subjects; n = 51). PBMC of PI subjects proliferated significantly more to O. volvulus antigen (OvAg) than did PBMC of microfiladermic subjects but less to streptolysin-O. Cytokine analysis of PBMC culture supernatants revealed that PI subjects (n = 11) produced significantly more interferon-γ to OvAg than did those in the microfiladermic group (n =18), less IL-5 to nonparasite antigen and mitogen, and less IL-10 spontaneously. Thus, immunity to O. volvulus may in part be mediated by an antigen-specific Th1-type response.
KW  - helminths
KW  - human diseases
KW  - immunity
KW  - interferon
KW  - interleukin 10
KW  - interleukin 5
KW  - onchocerciasis
KW  - parasites
KW  - T lymphocytes
KW  - Ecuador
KW  - South America
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804735&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immune responsiveness and the pathogenesis of human onchocerciasis.
AU  - Ottesen, E. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 3
SP  - 659
EP  - 671
SN  - 0022-1899
AD  - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950804736.  Publication Type: Journal Article.  Language: English.  Number of References: 76 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - This review focuses on the pathogenesis (especially immune-mediated) of Onchocerca-induced tissue damage, after first detailing what is known about the systemic alterations in host responsiveness caused by O. volvulus infection. Prominent antibody but minimal cellular proliferative responses to parasite antigen typify the systemic immune response of patients with onchocerciasis. While components of this response are proinflammatory (and antiparasitic), the primary force driving the immune system is the need to contain or limit inflammation around microfilariae that die in the skin or elsewhere at rates up to hundreds of thousands per day. These dying parasites initiate local inflammatory reactions, with the result being "bystander" tissue damage, which cumulatively determines host pathology. Local and systemic immune mechanisms to contain inflammation (e.g., blocking antibodies, down-regulating cytokines) are prominent in infected patients, and their delineation is crucial to understanding the pathogenesis of onchocercal disease in the skin, eye and elsewhere. The degree of pathology appears to be directly related to both microfilarial numbers and the intensity of proinflammatory responses to them and inversely related to the effectiveness of specific mechanisms to suppress this inflammation.
KW  - helminths
KW  - human diseases
KW  - immunopathology
KW  - onchocerciasis
KW  - parasites
KW  - pathogenesis
KW  - reviews
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - immunopathogenesis
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804736&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Pneumonia and bacteremia by pneumococcal serotype 16 in a human immunodeficiency virus-infected child with normal serum antibody response to 23-valent Pneumovax vaccine.
AU  - Hirschfeld, S.
AU  - Schiffman, G.
AU  - Tudor-Williams, G.
AU  - Pizzo, P. A.
T2  - Journal of Infectious Diseases
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 3
SP  - 761
EP  - 762
SN  - 0022-1899
AD  - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003821.  Publication Type: Correspondence.  Language: English.  Number of References: 10 ref.
KW  - bacterial diseases
KW  - children
KW  - HIV infections
KW  - human diseases
KW  - immunization
KW  - paediatrics
KW  - pneumonia
KW  - vaccines
KW  - man
KW  - Streptococcus pneumoniae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Streptococcus
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - pediatrics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003821&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes B virus infection.
AU  - Freifeld, A. G.
AU  - Hilliard, J.
AU  - Southers, J.
AU  - Murray, M.
AU  - Savarese, B.
AU  - Schmitt, J. M.
AU  - Straus, S. E.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 4
SP  - 1031
EP  - 1034
SN  - 0022-1899
AD  - Freifeld, A. G.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952004859.  Publication Type: Journal Article.  Language: English.  Subject Subsets: Public Health
N2  - Herpes B virus (BV) is a common cause of recurring mucocutaneous infections in monkeys of the genus Macaca. Like its human counterpart, herpes simplex virus (HSV), BV establishes lifelong latency and can be reactivated from infected monkeys symptomatically or asymptomatically. Incidental infection of humans handling BV-shedding monkeys can result in fatal meningoencephalitis. To determine whether humans exposed to infected monkeys can acquire asymptomatic BV infections, 480 subjects were evaluated in a controlled seroprevalence study. Sera from 321 primate handlers, including many with repeated injuries inflicted by Macaca monkeys, and 159 people never exposed to monkeys were tested in blinded fashion by both competition ELISA and Western blot to determine the prevalence of BV and HSV seropositivity. Although 293 persons proved positive for HSV antibodies, no primate handlers or control subjects showed BV-specific antibody responses. There is no serological evidence that BV causes asymptomatic infections in humans.
KW  - herpes
KW  - human diseases
KW  - infection
KW  - laboratory animals
KW  - occupational hazards
KW  - occupations
KW  - serological surveys
KW  - seroprevalence
KW  - workers
KW  - North America
KW  - USA
KW  - cercopithecine herpesvirus 1
KW  - man
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - seroepidemiology
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004859&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy.
AU  - Kojima, E.
AU  - Shirasaka, T.
AU  - Anderson, B. D.
AU  - Chokekijchai, S.
AU  - Steinberg, S. M.
AU  - Broder, S.
AU  - Yarchoan, R.
AU  - Mitsuya, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 5
SP  - 1152
EP  - 1158
SN  - 0022-1899
AD  - Kojima, E.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006100.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 69655-05-6, 30516-87-1. 
KW  - development
KW  - didanosine
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - mutations
KW  - patients
KW  - therapy
KW  - viraemia
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - dideoxyinosine
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - therapeutics
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006100&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Five-year follow-up of a phase I study of didanosine in patients with advanced human immunodeficiency virus infection.
AU  - Nguyen, B. Y.
AU  - Yarchoan, R.
AU  - Wyvill, K. M.
AU  - Venzon, D. J.
AU  - Pluda, J. M.
AU  - Mitsuya, H.
AU  - Broder, S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 5
SP  - 1180
EP  - 1189
SN  - 0022-1899
AD  - Nguyen, B. Y.: Medicine Branch, Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006104.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 69655-05-6. 
KW  - didanosine
KW  - disease course
KW  - follow up
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - patients
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dideoxyinosine
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006104&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A phase I/II study of 2′-deoxy-3′-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection.
AU  - Pluda, J. M.
AU  - Cooley, T. P.
AU  - Montaner, J. S. G.
AU  - Shay, L. E.
AU  - Reinhalter, N. E.
AU  - Warthan, S. N.
AU  - Ruedy, J.
AU  - Hirst, H. M.
AU  - Vicary, C. A.
AU  - Quinn, J. B.
AU  - Yuen, G. J.
AU  - Wainberg, M. A.
AU  - Rubin, M.
AU  - Yarchoan, R.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 171
IS  - 6
SP  - 1438
EP  - 1447
SN  - 0022-1899
AD  - Pluda, J. M.: Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19952007870.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 134678-17-4. 
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - lamivudine
KW  - patients
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 3TC
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007870&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serologic response to human papillomavirus type 16 (HPV-16) virus-like particles in HPV-16 DNA-positive invasive cervical cancer and cervical intraepithelial neoplasia grade III patients and controls from Colombia and Spain.
AU  - Nonnenmacher, B.
AU  - Hubbert, N. L.
AU  - Kirnbauer, R.
AU  - Shah, K. V.
AU  - Muñoz, N.
AU  - Bosch, F. X.
AU  - Sanjosé, S. de
AU  - Viscidi, R.
AU  - Lowy, D. R.
AU  - Schiller, J. T.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 1
SP  - 19
EP  - 24
SN  - 0022-1899
AD  - Nonnenmacher, B.: Laboratory of Cellular Oncology, National Cancer Institute, NIH, Building 36, Room 1D32, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008997.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Public Health; Tropical Diseases
N2  - A human papillomavirus (HPV) type 16 virus-like particle-based ELISA was used to assess antivirion immune responses in 300 women participating in cervical cancer case-control studies in Colombia and Spain. Virion IgG antibodies were detected in the sera of 51% and 59% of women with HPV-16 DNA-positive invasive cervical cancer and 81% and 73% of women with HPV-16 DNA-positive cervical intraepithelial neoplasia grade III (CIN III) in Colombia and Spain, respectively. Capsid antibodies were detected in 22% and 3% of cancer controls (P &lt;0.001) and in 43% and 10% of CIN III controls (P = 0.010) from Colombia and Spain, respectively. Since Colombia has an 8-fold higher incidence of cervical cancer, these results demonstrate an association between ELISA positivity and cancer risk. Capsid antibody responses did not correlate with humoral responses of the same women to HPV-16 E6 and E7 oncoproteins.
KW  - antibodies
KW  - cervical cancer
KW  - controls
KW  - detection
KW  - ELISA
KW  - human diseases
KW  - infections
KW  - neoplasms
KW  - patients
KW  - virus-like particles
KW  - Colombia
KW  - Europe
KW  - South America
KW  - Spain
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - Papillomaviridae
KW  - cancers
KW  - enzyme linked immunosorbent assay
KW  - human papillomavirus
KW  - Papovaviridae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008997&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Seroprevalence of human T cell lymphotropic virus type II infection, with or without human immunodeficiency virus type 1 coinfection, among US intravenous drug users.
AU  - Briggs, N. C.
AU  - Battjes, R. J.
AU  - Cantor, K. P.
AU  - Blattner, W. A.
AU  - Yellin, F. M.
AU  - Wilson, S.
AU  - Ritz, A. L.
AU  - Weiss, S. H.
AU  - Goedert, J. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 1
SP  - 51
EP  - 58
SN  - 0022-1899
AD  - Briggs, N. C.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19952009000.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Public Health
N2  - Seroprevalence of human T-cell lymphotropic virus (HTLV) and human immunodeficiency virus type 1 (HIV-1) was determined among 7841 injecting drug users (IDUs) from drug treatment centres in Baltimore, Chicago, Los Angeles, New Jersey (Asbury Park and Trenton), New York City (Brooklyn and Harlem), Philadelphia, and San Antonio, Texas; 20.9% had evidence of HTLV infection, as determined using a p21e EIA for screening and p21e blot for confirmation. With a type-specific EIA and blot used in combination, HTLV-II was identified in 97.6% of HTLV-positive IDUs whose sera could be subtyped. HIV-1 seroprevalence was 13.2%. HTLV-II without HIV-1 was most common in Los Angeles and San Antonio. HIV-1 without HTLV-II was most common in New York, New Jersey, and Baltimore. Dual infection was most common in New York and New Jersey. Logistic regression analysis revealed that seroprevalence of HTLV-II was significantly greater with HIV-1 infection and increasing age and among women, blacks, and Mexican-Americans. In conclusion, it appears that among USA IDUs, nearly all HTLV infection is attributable to HTLV-II, and HTLV-II infection is associated with HIV-1 and sociodemographic background.
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - infections
KW  - injecting drug users
KW  - mixed infections
KW  - seroprevalence
KW  - North America
KW  - USA
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type ii
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - i.v. drug abusers
KW  - i.v. drug users
KW  - intravenous drug users
KW  - multiple infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency.
AU  - Rausch, D. M.
AU  - Heyes, M. P.
AU  - Murray, E. A.
AU  - Eiden, L. E.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 1
SP  - 59
EP  - 69
SN  - 0022-1899
AD  - Rausch, D. M.: Section on Molecular Neuroscience, Laboratory of Cell Biology, National Institute of Mental Health, Bldg. 36, Room 3A17, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008717.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Registry Number: 30516-87-1. 
KW  - animal models
KW  - central nervous system
KW  - immunological deficiency
KW  - infants
KW  - survival
KW  - treatment
KW  - zidovudine
KW  - Macaca
KW  - man
KW  - simian immunodeficiency virus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AZT
KW  - CNS
KW  - immune deficiency
KW  - immunodeficiency
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008717&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transplantation of skin from human immunodeficiency virus type 1-transgenic mice to normal congenic mice results in graft rejection.
AU  - Dumois, J. A.
AU  - VanderVegt, F. P.
AU  - Kopp, J. B.
AU  - Marinos, N. J.
AU  - Rooney, J. F.
AU  - Notkins, A. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 1
SP  - 232
EP  - 234
SN  - 0022-1899
AD  - Dumois, J. A.: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bldg. 30, Room 121, 30 CONVENT DR MSC 4322, Bethesda MD 20892-4322, USA.
N1  - Accession Number: 19952008724.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref.
KW  - animal models
KW  - envelope protein gp120
KW  - graft rejection
KW  - grafts
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - skin
KW  - skin grafting
KW  - transplantation
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dermis
KW  - gp120
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008724&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Clearance of circulating filarial antigen as a measure of the macrofilaricidal activity of diethylcarbamazine in Wuchereria bancrofti infection.
AU  - McCarthy, J. S.
AU  - Guinea, A.
AU  - Weil, G. J.
AU  - Ottesen, E. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 2
SP  - 521
EP  - 526
SN  - 0022-1899
AD  - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950809864.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 90-89-1, 1642-54-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Small doses of diethylcarbamazine (DEC) clear microfilariae (MF) from the blood of Wuchereria bancrofti-infected persons, but the dose and regimen required to kill adult worms is not clearly defined. A prospective study was undertaken to examine the macrofilaricidal effect of DEC and the ability of an assay for circulating filarial antigen (CFA) to define the effect. Twenty-five MF-positive subjects and 7 MF-negative but CFA-positive subjects were treated with DEC and followed for 18 months. Of the 25 MF-positive patients, 24 cleared MF, and 22 of 26 CFA-positive subjects cleared CFA. A significantly greater decrease in antifilarial IgG4 was seen in patients who cleared CFA than in those who did not. The complete clearance of CFA observed after therapy with DEC indicates that assessment of CFA clearance is a useful means for detecting macrofilaricidal effects of antifilarial chemotherapy.
KW  - activity
KW  - anthelmintics
KW  - antigens
KW  - circulating antigens
KW  - clearance
KW  - diethylcarbamazine
KW  - drug therapy
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - infection
KW  - parasites
KW  - man
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - chemotherapy
KW  - immunogens
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809864&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased human immunodeficiency virus (HIV) type 1 DNA content and quinolinic acid concentration in brain tissues from patients with HIV encephalopathy.
AU  - Sei, S.
AU  - Saito, K.
AU  - Stewart, S. K.
AU  - Crowley, J. S.
AU  - Brouwers, P.
AU  - Kleiner, D. E.
AU  - Katz, D. A.
AU  - Pizzo, P. A.
AU  - Heyes, M. P.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 3
SP  - 638
EP  - 647
SN  - 0022-1899
AD  - Sei, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952010197.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 9007-49-2. 
KW  - brain
KW  - central nervous system
KW  - clinical aspects
KW  - concentration
KW  - dna
KW  - encephalopathy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - patients
KW  - tissues
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - clinical picture
KW  - CNS
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010197&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The relative distribution of T cell subsets is altered in Jamaican children infected with human T cell lymphotropic virus type 1.
AU  - Maloney, E. M.
AU  - Pate, E.
AU  - Wiktor, S. Z.
AU  - Morais, P.
AU  - Mann, D.
AU  - Gray, R.
AU  - Manns, A.
AU  - Blattner, W. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 3
SP  - 867
EP  - 870
SN  - 0022-1899
AD  - Maloney, E. M.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd., Room 434, Rockville, MD 20852, USA.
N1  - Accession Number: 19952010226.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref.
KW  - CD4 antigens
KW  - children
KW  - HTLV-I infections
KW  - human diseases
KW  - markers
KW  - risk groups
KW  - T lymphocytes
KW  - Jamaica
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - CD4
KW  - HLA-DR
KW  - HTLV-BLV group
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010226&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of macrophage colony-stimulating factor on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus.
AU  - Roilides, E.
AU  - Sein, T.
AU  - Holmes, A.
AU  - Chanock, S.
AU  - Blake, C.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 4
SP  - 1028
EP  - 1034
SN  - 0022-1899
AD  - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200205.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The effects of recombinant human macrophage colony-stimulating factor (M-CSF) on antifungal activity of human monocytes (MNC), MNC-derived macrophages (MDM) and rabbit pulmonary alveolar macrophages (PAM) against A. fumigatus were studied. MNC-induced hyphal damage was augmented by incubation with M-CSF (P=0.027); PAM-induced hyphal damage was moderately enhanced by M-CSF (P=0.046). Phagocytosis of Aspergillus conidia by MDM and PAM was strongly enhanced by M-CSF (P&lt;0.01). MNC pretreated with M-CSF exhibited enhanced superoxide anion production in response to PMA (P=0.026). This effect was not associated with increased levels of mRNA transcripts of the components of NADPH oxidase, the enzyme responsible for superoxide anion production. It is concluded that M-CSF augments antifungal activity of mononuclear phagocytes against both conidia and hyphae of A. fumigatus partly by enhancement of oxidation-dependent mechanisms and may have an important immunomodulatory role in prevention and treatment of invasive aspergillosis in leukopenic patients.
KW  - colony stimulating factor
KW  - immunology
KW  - monocytes
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200205&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case-control study of cervical neoplasia.
AU  - Wideroff, L.
AU  - Schiffman, M. H.
AU  - Nonnenmacher, B.
AU  - Hubbert, N.
AU  - Kirnbauer, R.
AU  - Greer, C. E.
AU  - Lowy, D.
AU  - Lorincz, A. T.
AU  - Manos, M. M.
AU  - Glass, A. G.
AU  - Scott, D. R.
AU  - Sherman, M. E.
AU  - Kurman, R. J.
AU  - Buckland, J.
AU  - Tarone, R. E.
AU  - Schiller, J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1995///
VL  - 172
IS  - 6
SP  - 1425
EP  - 1430
SN  - 0022-1899
AD  - Wideroff, L.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962001271.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Public Health
N2  - An ELISA to detect serum IgG antibody response to human papillomavirus (HPV) type 16 virus-like particles (VLPs) was evaluated in a case-control study of cervical neoplasia, nested within a prospective cohort study in Oregon, USA. Subjects included 688 controls with continued normal cytology and 152 cases with confirmed incident squamous intraepithelial lesions who were tested for DNA of a broad spectrum of HPV types at cohort enrolment and follow-up. Of controls, 16.6% were seropositive compared with 30.8% and 52.4% of cases with low- and high-grade lesions, respectively. Of HPV-16 DNA-negative subjects, 16.5% were seropositive. Seropositivity increased from 22.2% in subjects who were HPV-16 DNA-positive by polymerase chain reaction once only (enrolment or follow-up) to 83.3% in those who were HPV-16 DNA-positive at both time points. These data imply that serum antibody to HPV-16 VLPs is a relatively sensitive indicator of persisting cervical HPV-16 infection.
KW  - cervical cancer
KW  - cervix
KW  - elisa
KW  - evaluation
KW  - human diseases
KW  - infections
KW  - neoplasms
KW  - North America
KW  - Oregon
KW  - USA
KW  - human papillomavirus 16
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - Papillomaviridae
KW  - cancer sites
KW  - cancers
KW  - enzyme linked immunosorbent assay
KW  - human papillomavirus
KW  - Papovaviridae
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001271&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan.
AU  - Sacks, D. L.
AU  - Pimenta, P. F. P.
AU  - McConville, M. J.
AU  - Schneider, P.
AU  - Turco, S. J.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1995///
VL  - 181
IS  - 2
SP  - 685
EP  - 697
SN  - 0022-1007
AD  - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950803478.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - The structure and function of the abundant surface lipophosphoglycan (LPG) on Leishmania donovani promastigotes were investigated. During metacyclogenesis, the salient structural feature of LPG was conserved, involving expression of a phosphoglycan chain made up of unsubstituted disaccharide-phosphate repeats. Two important developmental modifications were observed: the size of the molecule was substantially increased because of a 2-fold increase in the number of phosphorylated disaccharide repeat units expressed, and there was a concomitant decrease in the presentation of terminally exposed sugars which was indicated by the reduced accessibility of terminal galactose residues to galactose oxidase and the loss of binding by the lectins, peanut agglutinin and concanavalin A, to metacyclic LPG in vivo and in vitro. The loss of lectin binding was not due to downregulation of the capping oligosaccharides, as the same β-linked galactose or α-linked mannose-terminating oligosaccharides were present in both procyclic and metacyclic promastigotes. The capping sugars on procyclic LPG mediated procyclic attachment to the sand fly (Phlebotomus argentipes) midgut, whereas these same sugars on metacyclic LPG failed to mediate metacyclic binding. Intact metacyclic LPG did not inhibit procyclic attachment but depolymerized LPG did, demonstrating that the ligands are normally buried. The masking of the terminal sugars was attributed to folding and clustering of the extended phosphoglycan chains. The exposure and subsequent masking of the terminal capping sugars explain the stage specificity of promastigote attachment to and release from the vector midgut, which are key events in the development of transmissible infections.
KW  - developmental stages
KW  - disease transmission
KW  - disease vectors
KW  - host parasite relationships
KW  - lectins
KW  - lipophosphoglycans
KW  - midgut
KW  - parasites
KW  - polysaccharides
KW  - promastigotes
KW  - transmission
KW  - vectors
KW  - Diptera
KW  - Leishmania donovani
KW  - Phlebotominae
KW  - Phlebotomus argentipes
KW  - protozoa
KW  - Psychodidae
KW  - Sarcomastigophora
KW  - Trypanosomatidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - complex carbohydrates
KW  - growth phase
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803478&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and in vitro lymphocyte apoptosis.
AU  - Leno, M.
AU  - Simpson, R. M.
AU  - Bowers, F. S.
AU  - Kindt, T. J.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1995///
VL  - 181
IS  - 4
SP  - 1575
EP  - 1580
SN  - 0022-1007
AD  - Leno, M.: Correspondence address: T. J. Kindt, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Faculty, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland, USA.
N1  - Accession Number: 19952007631.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
KW  - animal models
KW  - apoptosis
KW  - HTLV infections
KW  - human diseases
KW  - pathogenesis
KW  - man
KW  - rabbits
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007631&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Activation of virus replication after vaccination of HIV-1-infected individuals.
AU  - Staprans, S. I.
AU  - Hamilton, B. L.
AU  - Follansbee, S. E.
AU  - Elbeik, T.
AU  - Barbosa, P.
AU  - Grant, R. M.
AU  - Feinberg, M. B.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1995///
VL  - 182
IS  - 6
SP  - 1727
EP  - 1737
SN  - 0022-1007
AD  - Staprans, S. I.: Correspondence address: M.B.Feinberg, Office of AIDS Research, Office of the Director, National Institutes of Health, Building 31, Room 4C06, 31 Center Drive, MSC 2340, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001517.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
KW  - acquired immune deficiency syndrome
KW  - CD4+ lymphocytes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunization
KW  - influenza
KW  - replication
KW  - vaccines
KW  - viraemia
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD4+ cells
KW  - flu
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - T4 lymphocytes
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001517&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Multiple determinants for growth of human immunodeficiency virus type 1 in monocyte-macrophages.
AU  - Malykh, A.
AU  - Reitz, M. S. Jr
AU  - Louie, A.
AU  - Hall, L.
AU  - Lori, F.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1995///
VL  - 206
IS  - 1
SP  - 646
EP  - 650
SN  - 0042-6822
AD  - Malykh, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962003285.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - macrophages
KW  - monocytes
KW  - pathogenesis
KW  - tropisms
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003285&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cells.
AU  - O'Brien, M. C.
AU  - Ueno, T.
AU  - Jahan, N.
AU  - Zajac-Kaye, M.
AU  - Mitsuya, H.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1995///
VL  - 207
IS  - 3
SP  - 903
EP  - 909
SN  - 0006-291X
AD  - O'Brien, M. C.: The Experimental Retrovirology Section, Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002838.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 9007-49-2. 
KW  - acquired immune deficiency syndrome
KW  - antineoplastic agents
KW  - antiviral agents
KW  - binding
KW  - cells
KW  - DNA
KW  - HIV infections
KW  - human diseases
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cytotoxic agents
KW  - deoxyribonucleic acid
KW  - expression
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002838&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes.
AU  - Cara, A.
AU  - Guarnaccia, F.
AU  - Reitz, M. S. Jr
AU  - Gallo, R. C.
AU  - Lori, F.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1995///
VL  - 208
IS  - 1
SP  - 242
EP  - 248
SN  - 0042-6822
AD  - Cara, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962005073.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - integration
KW  - macrophages
KW  - pathogenesis
KW  - replication
KW  - t lymphocytes
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005073&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 infection of primary human neuroblasts.
AU  - Ensoli, F.
AU  - Cafaro, A.
AU  - Fiorelli, V.
AU  - Vannelli, B.
AU  - Ensoli, B.
AU  - Thiele, C. J.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1995///
VL  - 210
IS  - 1
SP  - 221
EP  - 225
SN  - 0042-6822
AD  - Ensoli, F.: Cell and Molecular Biology Section, Paediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962005919.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
KW  - central nervous system
KW  - hiv infections
KW  - human diseases
KW  - nerve tissue
KW  - neurons
KW  - Deltaretrovirus
KW  - Human immunodeficiency virus 1
KW  - human t-cell lymphotropic virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - CNS
KW  - HTLV-BLV group
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - nerve cells
KW  - neurones
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005919&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.
AU  - Toohey, K.
AU  - Wehrly, K.
AU  - Nishio, J.
AU  - Perryman, S.
AU  - Cheesbro, B.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1995///
VL  - 213
IS  - 1
SP  - 70
EP  - 79
SN  - 0042-6822
AD  - Toohey, K.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19962008279.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref.
KW  - envelope glycoproteins
KW  - HIV-1 infections
KW  - human diseases
KW  - macrophages
KW  - pathogenesis
KW  - phenotypes
KW  - replication
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - hypervariable regions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008279&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 mediates rapid apoptosis of lymphocytes from human CD4 transgenic but not normal rabbits.
AU  - Leng, M.
AU  - Hague, B. F.
AU  - Teller, R.
AU  - Kindt, T. J.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1995///
VL  - 213
IS  - 2
SP  - 450
EP  - 454
SN  - 0042-6822
AD  - Leng, M.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA.
N1  - Accession Number: 19962002639.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref.
KW  - apoptosis
KW  - CD4 antigens
KW  - genetically engineered organisms
KW  - HIV infections
KW  - human diseases
KW  - immunology
KW  - T lymphocytes
KW  - transgenic animals
KW  - Human immunodeficiency virus 1
KW  - man
KW  - rabbits
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - CD4
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GMOs
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - transgenic organisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002639&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of the lower-molecular-mass fraction of venoms from Dendroaspis jamesoni kaimosae and Micrurus fulvius using capillary-electrophoresis electrospray mass spectrometry.
AU  - Perkins, J. R.
AU  - Tomer, K. B.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995///
VL  - 233
IS  - 3
SP  - 815
EP  - 827
SN  - 0014-2956
AD  - Perkins, J. R.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, USA.
N1  - Accession Number: 19972005059.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
N2  - Capillary electrophoresis (CE) with electrospray ionization (ESI) and selected ion-monitoring mass-spectrometric (SIM-MS) detection was used to provide as much information as possible about the lower molecular-mass fraction (peptides of molecular masses up to 8500 Da) of the venoms of Dendroaspis jamesoni kaimosae (Jameson's mamba) and Micrurus fulvius (Eastern coral snake). Method development was based on the venom of D. jamesoni kaimosae, which contains some previously described peptides, with subsequent application to the completely unknown venom of M. fulvius. CE-ESI-SIM-MS provides a rapid and extremely sensitive method for the detection and molecular-mass determination of peptides present in venoms. It was utilized to provide molecular masses and thus, by inference, confirmation of the peptide compositions for those toxins which have been previously described in the literature. This methodology indicates the presence of 83 peptides in the venom of D. jamesoni kaimosae and 49 peptides in the venom of M. fulvius in the molecular-mass range 6000-8500 Da.
KW  - characterization
KW  - electrophoresis
KW  - mass spectrometry
KW  - peptides
KW  - venoms
KW  - Dendroaspis
KW  - Micrurus fulvius
KW  - snakes
KW  - Elapidae
KW  - snakes
KW  - reptiles
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Micrurus
KW  - Dendroaspis jamesoni kaimosae
KW  - venom
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005059&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reexamining AIDS research priorities.
AU  - Paul, W. E.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1995///
VL  - 267
IS  - 5198
SP  - 633
EP  - 636
SN  - 0036-8075
AD  - Paul, W. E.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952003702.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Public Health
N2  - The director of the NIH's Office of AIDS Research summarizes the scientific opportunities afforded by AIDS research, ranging from protective immunity and cytokines to behavioural research and prevention of sexually transmitted diseases and female barrier methods.D.W. FitzSimons
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - behaviour
KW  - HIV infections
KW  - immunology
KW  - policy
KW  - research
KW  - sexually transmitted diseases
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - behavior
KW  - human immunodeficiency virus infections
KW  - sexually transmitted infections
KW  - STDs
KW  - studies
KW  - United States of America
KW  - venereal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003702&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Influence of valine flooding on channeling of valine into tissue pools and on protein synthesis.
AU  - Smith, C. B.
AU  - Sun, Y.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1995///
VL  - 268
IS  - 4
SP  - E735
EP  - E744
SN  - 0002-9513
AD  - Smith, C. B.: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951408057.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 72-18-4.  Subject Subsets: Human Nutrition
N2  - Rates of valine incorporation into protein were measured under control and valine-"flooding" conditions in Sprague-Dawley rats and included correction for the degree of recycling of unlabelled valine derived from the steady-state breakdown of tissue protein into the precursor pool (tRNA bound). The correction factor λ, which is the ratio of the steady-state specific activity of valine in the tissue tRNA-bound pool to that in the arterial plasma, was estimated for each of the tissues. In controls, values of λ ranged from 0.31 in adrenals to 0.54 in heart; in flooded rats, values were higher, but only in liver was the value of λ close to 1.0. In control and flooded rats, rates of protein synthesis were highest in liver and adrenals and lowest in skeletal muscle, with intermediate values in brain and heart. Flooding resulted in increased rates of protein synthesis in liver and decreased rates in adrenals. Rates of protein synthesis in brain, heart and skeletal muscle were not significantly affected by flooding.
KW  - amino acids
KW  - infusion
KW  - protein synthesis
KW  - tissues
KW  - valine
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - protein biosynthesis
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408057&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats.
AU  - Corwin, R. L.
AU  - Rowe, P. M.
AU  - Crawley, J. N.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1995///
VL  - 269
IS  - 3, 2
SP  - R511
EP  - R518
SN  - 0002-9513
AD  - Corwin, R. L.: Section on Behavioural Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951414333.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - The neuropeptide galanin has been proposed to play a role in the regulation of fat intake. The purpose of the present investigation was to examine if galanin and the galanin receptor antagonist M40 would have selective effects on fat intake in a fat-diet choice paradigm in male Sprague-Dawley rats. Rats were adapted to 22-h access to diet alone and 2-h daily access to separate sources of fat and diet in the early dark cycle. Galanin (300 pmol, 1 nmol) or M40 (2-500 pmol) was micro inserted bilaterally into the paraventricular nucleus of the hypothalamus (PVN) before the 2-h choice period, and diet and fat intake were measured. M40 had no effect on diet or fat intake. Galanin stimulated diet intake and increased the ratio of diet to fat consumed but had no significant effect on fat intake alone. These results suggest that endogenous galanin in the PVN may not play a primary role in the regulation of fat intake when fat is available in addition to a nutritionally balanced diet.
KW  - antagonists
KW  - fats
KW  - food intake
KW  - intake
KW  - neuropeptides
KW  - obesity
KW  - receptors
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414333&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.
AU  - Yu, G.
AU  - Shen, F. S.
AU  - Sturch, S.
AU  - Aquino, A.
AU  - Glazer, R. I.
AU  - Felsted, R. L.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 9
SP  - 4792
EP  - 4796
SN  - 0021-9258
AD  - Yu, G.: Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19952005414.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 9026-43-1. 
KW  - biochemistry
KW  - cellular biology
KW  - gag protein
KW  - gene expression
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - phosphorylation
KW  - protein kinase
KW  - regulation
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cell biology
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms.
AU  - Welch, R. W.
AU  - Wang, Y.
AU  - Crossman, A., Jr.
AU  - Park, J. B.
AU  - Kirk, K. L.
AU  - Levine, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 21
SP  - 12584
EP  - 12592
SN  - 0021-9258
AD  - Welch, R. W.: Laboratory of Cell Biology and Genetics, National Institutes of Health, Bethesda, Maryland 20892-0850, USA.
N1  - Accession Number: 19961403421.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 50-81-7, 490-83-5.  Subject Subsets: Human Nutrition
N2  - To investigate whether ascorbate alone, dehydroascorbic acid alone, or both are transported into cells, specific assays for each compound, freshly synthesized pure dehydroascorbic acid, the specially synthesized analogue 6-chloroascorbate, and a new assay for 6-chloroascorbate were undertaken. Ascorbate and dehydroascorbic acid were transported and accumulated distinctly; neither competed with the other. Ascorbate was accumulated as ascorbate by sodium-dependent carrier-mediated active transport. Dehydroascorbic acid transport and accumulation as ascorbate was at least 10-fold faster than ascorbate transport and was sodium-independent. Once transported, dehydroascorbic acid was immediately reduced intracellularly to ascorbate. The analogue 6-chloroascorbate had no effect on dehydroascorbic acid transport but was a competitive inhibitor of ascorbate transport. The Ka for 6-chloroascorbate (2.9-4.4 µM) was similar to the Km for ascorbate transport (9.8-12.6 µM). 6-Chloroascorbate was itself transported and accumulated in fibroblasts by a sodium-dependent transporter. The data provide new information that ascorbate and dehydroascorbic acid are transported into neutrophils and fibroblasts by 2 distinct mechanisms and that the compound available for intracellular utilization is ascorbate.
KW  - active transport
KW  - analogues
KW  - ascorbic acid
KW  - cell cultures
KW  - dehydroascorbic acid
KW  - transport
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - accumulation
KW  - analogs
KW  - transportation
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403421&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification of a variant-specific surface protein of Giardia lamblia and characterization of its metal-binding properties.
AU  - Luján, H. D.
AU  - Mowatt, M. R.
AU  - Wu JingJing
AU  - Lu Yun
AU  - Lees, A.
AU  - Chance, M. R.
AU  - Nash, T. E.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 23
SP  - 13807
EP  - 13813
SN  - 0021-9258
AD  - Luján, H. D.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960800373.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 52-90-4, 7439-89-6, 7440-66-6.  Subject Subsets: Protozoology
N2  - Giardia lamblia [G. duodenalis] undergoes surface antigenic variation by modulating the expression of different variant-specific surface proteins (VSP) which are cysteine-rich and bind zinc and other heavy metals in vitro. An immunoaffinity chromatographic method was developed to purify a VSP in order to determine its biochemical properties. The sequences of 2 different proteolytic fragments agreed with the sequence deduced from the cloned gene and the amino-terminal sequence indicated the removal of a 14-residue signal peptide, consistent with the transport of VSP to the cell surface. The protein was not glycosylated and had an isoelectric point of 5.3. X-ray microanalyses indicated that the major metals in G. lamblia trophozoites, as well as in purified VSP, are zinc and iron. The zinc concentration in G. lamblia cells was found to be 0.43 and the iron concentration 0.80 mM. It is proposed that metal coordination stabilizes the VSPs, rendering them resistant to proteolytic attack in the upper small intestine. The ability of G. lamblia to bind ions may play a role in nutritional deficiency and/or malabsorption in heavily infected persons.
KW  - binding
KW  - binding proteins
KW  - biochemistry
KW  - chromatography
KW  - cysteine
KW  - cytochemistry
KW  - giardiasis
KW  - human diseases
KW  - ions
KW  - iron
KW  - malabsorption
KW  - metals
KW  - nutrient deficiencies
KW  - parasites
KW  - proteins
KW  - proteolysis
KW  - purification
KW  - small intestine
KW  - surface proteins
KW  - zinc
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - giardiosis
KW  - malabsorption syndrome
KW  - membrane proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800373&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain.
AU  - Bebenek, K.
AU  - Beard, W. A.
AU  - Casas-Finet, J. R.
AU  - Kim, H. R.
AU  - Darden, T. A.
AU  - Wilson, S. H.
AU  - Kunkel, T. A.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 33
SP  - 19516
EP  - 19523
SN  - 0021-9258
AD  - Bebenek, K.: Correspondence address: T. A. Kunkel, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19962001070.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 9068-38-6. 
KW  - amino acids
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mutations
KW  - reverse transcriptase
KW  - structure
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001070&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates.
AU  - Ueno, T.
AU  - Shirasaka, T.
AU  - Mitsuya, H.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 40
SP  - 23605
EP  - 23611
SN  - 0021-9258
AD  - Ueno, T.: Correspondence address: H. Mitsuya, The Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962001615.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9068-38-6. 
KW  - analogues
KW  - drug resistance
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mutations
KW  - nucleoside analogues
KW  - nucleosides
KW  - reverse transcriptase
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - analogs
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001615&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection.
AU  - Freed, E. O.
AU  - Martin, M. A.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 41
SP  - 23883
EP  - 23886
SN  - 0021-9258
AD  - Freed, E. O.: Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19962002680.  Publication Type: Journal Article.  Language: English.  Number of References: 153 ref.
KW  - acquired immune deficiency syndrome
KW  - envelope glycoproteins
KW  - HIV infections
KW  - human diseases
KW  - life cycle
KW  - molecular biology
KW  - proteins
KW  - reviews
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - function
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002680&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A helical epitope in the C4 domain of HIV glycoprotein 120.
AU  - Robey, F. A.
AU  - Kelson-Harris, T.
AU  - Roller, P. P.
AU  - Robert-Guroff, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1995///
VL  - 270
IS  - 41
SP  - 23918
EP  - 23921
SN  - 0021-9258
AD  - Robey, F. A.: Peptide and Immunochemistry Unit, Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002682.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref.
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - envelope protein gp120
KW  - envelope proteins
KW  - epitopes
KW  - HIV infections
KW  - human diseases
KW  - molecular biology
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - antigenic determinants
KW  - domain
KW  - gp120
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Scope of the AIDS epidemic in the United States.
AU  - Rosenberg, P. S.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1995///
VL  - 270
IS  - 5240
SP  - 1372
SN  - 0036-8075
AD  - Rosenberg, P. S.: National Cancer Institute, Rockville, MD 20852-4910, USA.
N1  - Accession Number: 19962001059.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
KW  - acquired immune deficiency syndrome
KW  - epidemiology
KW  - ethnic groups
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mathematical models
KW  - surveillance
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001059&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Birth weight and perinatal mortality: a comparison of the United States and Norway.
AU  - Wilcox, A.
AU  - Skjærven, R.
AU  - Buekens, P.
AU  - Kiely, J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 273
IS  - 9
SP  - 709
EP  - 711
SN  - 0098-7484
AD  - Wilcox, A.: Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19962001427.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Public Health
N2  - The authors set out to compare perinatal mortality in the USA and Norway, using a new analytic approach based on relative birth weight. They compared linked birth and perinatal death records for USA and Norwegian births from 1986 through 1987, the most recently available 2-year period. A total of 7 445 914 USA births and 105 084 Norwegian births. The higher rate of perinatal death in the USA compared with Norway is due to an excess of preterm deliveries in the USA. Low-weight, preterm births comprise 2.9% of US births compared with 2.1% of Norwegian births. If the USA could eliminate this slight excess of preterm delivery, perinatal mortality in the USA would decrease to the level in Norway. Unexpectedly, the survival of newborns at any given birth weight is virtually the same in the USA and Norway when newborns' birth weights are considered relative to their own nation's weight. Low rates of perinatal mortality in the Scandinavian countries have usually been attributed to the heavier weights of their newborns. Higher mortality among USA infants is in fact due entirely to a small excess of preterm deliveries. The lighter weights of USA newborns at term appear not to affect perinatal survival. Furthermore, the apparent survival advantage of low-weight USA newborns (used by policymakers as evidence of superior USA intensive neonatal care) may be at least partly an artifact. When weight-specific mortality rates are adjusted to relative low birth weight, low-weight newborns have the same survival in Norway as in the USA. The prevention of excess mortality among USA infants is concluded to depend on the prevention of preterm births, not on changes in mean birth weight.
KW  - birth weight
KW  - comparisons
KW  - infants
KW  - low birth weight infants
KW  - mortality
KW  - neonates
KW  - perinatal mortality
KW  - Europe
KW  - North America
KW  - Norway
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - Developed Countries
KW  - EFTA
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - APEC countries
KW  - North America
KW  - death rate
KW  - newborn infants
KW  - United States of America
KW  - Demography (UU200) 
KW  - Human Fertility (UU250) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001427&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell lymphotropic virus type I-associated adult T-cell leukemia. The Joseph Goldberger Clinical Investigator Lecture.
AU  - Waldmann, T. A.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 273
IS  - 9
SP  - 735
EP  - 737
SN  - 0098-7484
AD  - Waldmann, T. A.: Metabolism Branch, National Cancer Institute, Bldg 10, Room 4N115, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952008212.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 85898-30-2, 102524-44-7. 
KW  - adult T-cell leukaemia
KW  - human diseases
KW  - immunotherapy
KW  - interleukin 2
KW  - monoclonal antibodies
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - retroviridae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adult T-cell leukemia
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008212&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Promising new treatments for cytomegalovirus retinitis.
AU  - Polis, M. A.
AU  - Masur, H.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 273
IS  - 18
SP  - 1457
EP  - 1459
SN  - 0098-7484
AD  - Polis, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19952006928.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Public Health
N2  - A commentary.
KW  - human diseases
KW  - infections
KW  - retinitis
KW  - reviews
KW  - Human herpesvirus 5
KW  - man
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human cytomegalovirus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006928&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Breast cancer among radiologic technologists.
AU  - Boice, J. D., Jr.
AU  - Mandel, J. S.
AU  - Doody, M. M.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 274
IS  - 5
SP  - 394
EP  - 401
SN  - 0098-7484
AD  - Boice, J. D., Jr.: Radiation Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd, EPN/Room 408, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962000336.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Public Health
N2  - Of 105 385 female radiological technologists (certified by the American Registry of Radiologic Technologists since 1926) sent questionnaires to evaluate the risk of occupation associated breast cancer, 79 016 responded. Six hundred breast cancer cases were identified. Each of 528 eligible subjects with breast cancer was matched to five control subjects based on age, year of certification, and follow-up time. Study subjects had been certified for a mean of 29 years; 63.8% of cases and 62.6% of controls had worked as radiological technologists for 10 years or more. Significantly increased risks for breast cancer were associated with early age at menarche (for &lt;11 years of age: RR = 1.79: 95% confidence interval [CI], 1.09 to 2.94), nulliparity (PR = 1.36; 95% CI, 1.04 to 1.78), first-degree relative with history of breast cancer (RR = 2.07; 95% CI, 1.56 to 2.74), prior breast biopsy (RR = 1.53; 95% CI, 1.17 to 2.00), alcohol consumption (for &gt;14 alcoholic drinks per week: RR = 2.12; 95% CI, 1.06 to 4.27), thyroid cancer (RR = 5.36; 95% CI, 1.64 to 17.5), hyperthyroidism (RR = 1.66; 95% CI, 1.02 to 2.71), and residence in the northeastern USA (RR = 1.66; 95% CI, 1.19 to 2.30). Jobs involving radiotherapy, radioisotopes, or fluoroscopic equipment, however, were not linked to breast cancer risk, nor were personal exposures to fluoroscopy or multifilm procedures. Use of birth control pills, postmenopausal oestrogens, or permanent hair dyes also were not risk factors. Based on dosimetry records for 35% of study subjects, cumulative exposure appeared low. Among women who worked more than 20 years, the RR for breast cancer was 1.13 (95% CI, 0.79 to 1.64). The authors conclude that more than 50% of the reported breast cancers could be explained by established risk factors. Employment as a radiological technologist, however, was not found to increase the risk of breast cancer. The contribution of prolonged exposure to relatively low doses of ionizing radiation to breast cancer risk was too small to be detectable at this time.
KW  - breast
KW  - breast cancer
KW  - health care workers
KW  - human diseases
KW  - ionizing radiation
KW  - neoplasms
KW  - occupational health
KW  - occupations
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Studies of cancer and radiation dose among atomic bomb survivors.
AU  - Land, C. E.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 274
IS  - 5
SP  - 402
EP  - 407
SN  - 0098-7484
AD  - Land, C. E.: Radiation Epidemiology Branch, National Cancer Institute, EPN 408, 6130 Executive Blvd, MS 7362, Bethesda, MD 20892-7362, USA.
N1  - Accession Number: 19952009727.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Public Health
N2  - A comprehensive programme of medical follow-up of survivors of the atomic bombings of Hiroshima and Nagasaki, Japan, by the Radiation Effects Research Foundation (RERF) has produced quantitative estimates of cancer risk from exposure to ionizing radiation. For breast cancer in women, in particular, the strength of the radiation dose response and the generally low level of population risk in the absence of radiation exposure have led to a clear description of excess risk and its variation by age at exposure and over time following exposure. Comparisons of RERF data with data from medically irradiated populations have yielded additional information on the influence of population and underlying breast cancer rates on radiation-related risk. Epidemiological investigations of breast cancer cases and matched controls among atomic bomb survivors have clarified the role of reproductive history as a modifier of the carcinogenic effects of radiation exposure. Finally, a pattern of radiation-related risk by attained age among the survivors exposed during childhood or adolescence suggests the possible existence of a radiation-susceptible sub-group. The hypothetical existence of such a group is lent plausibility by the results of recent family studies suggesting that heritable mutations in certain genes are associated with familial aggregations of breast cancer. The recent isolation and cloning of one such gene, BRCA1, makes it likely that the hypothesis can be tested using molecular assays of archival and other tissue obtained from atomic bomb survivor cases and controls.
KW  - breast
KW  - breast cancer
KW  - epidemiology
KW  - fallout
KW  - human diseases
KW  - ionizing radiation
KW  - neoplasms
KW  - risk factors
KW  - Asia
KW  - Japan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - radioactive fallout
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009727&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HDL cholesterol predicts coronary heart disease mortality in older persons.
AU  - Corti, M. C.
AU  - Guralnik, J. M.
AU  - Salive, M. E.
AU  - Harris, T.
AU  - Field, T. S.
AU  - Wallace, R. B.
AU  - Berkman, L. F.
AU  - Seeman, T. E.
AU  - Glynn, R. J.
AU  - Hennekens, C. H.
AU  - Havlik, R. J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 274
IS  - 7
SP  - 539
EP  - 544
SN  - 0098-7484
AD  - Corti, M. C.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD, USA.
N1  - Accession Number: 19961404283.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The relation of total cholesterol and HDL cholesterol (HDL-C) with coronary heart disease (CHD) mortality and with occurrence of new CHD events in persons &gt;71 years old was examined in 2527 women and 1377 men. New CHD events were evaluated in persons with no CHD history or hospitalization. Death due to CHD. After adjustment for established CHD risk factors, the relative risk (RR) of death due to CHD for those with low HDL-C (&lt;0.90 mmol/litre) compared with the reference group (HDL-C ≥1.55 mmol/litre) was 2.5 (95% confidence interval (CI) 1.6-4.0). Elevated risk was present in subgroups 71-80 years old (RR 4.1; 95% CI 1.9-8.8) and over 80 years (RR 1.8; 95% CI 0.99-3.4), and in men and women. Low HDL-C predicted an increased risk of occurrence of new CHD events (RR 1.4; 95% CI 1.1-2.0), with similar but nonsignificant results in subgroups of men and women. Total cholesterol was less consistently associated with CHD mortality than HDL-C. When individuals with total cholesterol of at least 6.20 mmol/litre were compared with the reference group with total cholesterol of 4.16-5.19 mmol/litre, a significant risk of CHD mortality was seen for women (RR 1.8; 95% CI 1.03-3.0) but not for men (RR 1.0; 95% CI 0.5-2.0). In the total population, for each 1-unit increase in the total cholesterol/HDL-C ratio there was a 17% increase in the risk of CHD death that was significant. Low HDL-C predicts CHD mortality and occurrence of new CHD events in persons older than 70 years. Elevated total cholesterol was not found to be associated with CHD mortality in older men, but may be a risk factor for CHD in older women.
KW  - atherosclerosis
KW  - blood lipids
KW  - cholesterol
KW  - heart diseases
KW  - high density lipoprotein
KW  - mortality
KW  - old age
KW  - risk
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - arteriosclerosis
KW  - coronary diseases
KW  - death rate
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Safety of the blood supply.
AU  - Sloand, E. M.
AU  - Pitt, E.
AU  - Klein, H. G.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1995///
VL  - 274
IS  - 17
SP  - 1368
EP  - 1373
SN  - 0098-7484
AD  - Sloand, E. M.: National Heart, Lung and Blood Institute, 31 Center Drive, MSC 2490, Building 31, Room 4A11, Bethesda, MD 20892-2490, USA.
N1  - Accession Number: 19962000622.  Publication Type: Journal Article.  Language: English.  Number of References: 108 ref.
KW  - blood transfusion
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - safety
KW  - transmission
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ascorbic acid transport and distribution of human B lymphocytes.
AU  - Bergsten, P.
AU  - Yu, R.
AU  - Kehrl, J.
AU  - Levine, M.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1995///
VL  - 317
IS  - 1
SP  - 208
EP  - 214
SN  - 0003-9861
AD  - Bergsten, P.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19951413547.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Ascorbic acid transport was investigated in human B lymphocytes. The vitamin was transported by 2 components. The first was a high-affinity activity with an apparent Km of 7-10 µM and Vmax of 0.14 mM/h (3.11 × 10-4µmol × h-1× mg protein-1). The activity was concentration and temperature dependent, saturable and inhibited by carbonylcyanide-p-trifluoromethoxyphenylhydrazone and ouabain and generated ascorbic acid accumulation against a concentration gradient. Kinetics for the second component were indeterminate because ascorbate was not accumulated against a concentration gradient. Subcellular fractionation revealed that intracellular ascorbic acid in human B lymphocytes was &gt;90% localized to the cytosol and not protein bound. Kinetic parameters of high-affinity ascorbic acid transport could operate effectively with plasma concentrations normally found in man.
KW  - ascorbic acid
KW  - distribution
KW  - lymphocytes
KW  - transport
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - transportation
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Prophylactic immune globulin in children with HIV disease.
AU  - Mofenson, L. M.
AU  - Nugent, R.
AU  - Spector, S. A.\Gelber, R. D.\Wara, D. W.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1995///
VL  - 332
IS  - 11
SP  - 750
EP  - 751
SN  - 0028-4793
AD  - Mofenson, L. M.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952004309.  Publication Type: Correspondence.  Language: English.  Number of References: 8 ref. Registry Number: 308067-57-4, 723-46-6, 738-70-5. 
KW  - clinical trials
KW  - HIV infections
KW  - human diseases
KW  - immunoglobulins
KW  - immunotherapy
KW  - prophylaxis
KW  - sulfamethoxazole
KW  - treatment
KW  - trimethoprim
KW  - gamma-globulins
KW  - human immunodeficiency virus infections
KW  - immune globulins
KW  - sulphamethoxazole
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004309&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A population-based serologic survey of immunity to tetanus in the United States.
AU  - Gergen, P. J.
AU  - McQuillan, G. M.
AU  - Kiely, M.
AU  - Ezzati-Rice, T. M.
AU  - Sutter, R. W.
AU  - Virella, G.
AU  - Sanford, J. P.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1995///
VL  - 332
IS  - 12
SP  - 761
EP  - 766
SN  - 0028-4793
AD  - Gergen, P. J.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19962001357.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Public Health
N2  - To provide more accurate estimates, serum levels of antibody against tetanus were measured as part of the third National Health and Nutrition Examination Survey (NHANES III), which studied a representative sample of the civilian, non-institutionalized population of the USA. The authors measured tetanus antitoxin using a solid-phase enzyme immunoassay in serum samples from 10 618 persons 6 years of age and older who were examined during phase 1 of NHANES III in 1988 to 1991. Overall, 69.7% of Americans 6 years of age and older had protective levels of tetanus antibodies (&gt;0.15 IU/ml). The rate decreased from 87.7% among those 6 to 11 years of age to 27.8% among those 70 years of age or older. Among children 6 to 16 years of age, 82.2% had protective levels of tetanus antibodies, with little variation according to race or ethnicity. More men than women were immune (79.0% vs. 62.4%). Mexican Americans had a significantly lower rate of immunity (57.9%, P &lt;0.05) than either non-Hispanic whites (72.7%) or non-Hispanic blacks (68.1%). Those with a history of military service, higher levels of education, or incomes above the poverty level were more likely to have protective antibody levels. Although the prevalence of immunity declined rapidly starting at the age of 40 years, most of the 107 cases of tetanus (with 20 deaths) reported in 1989 and 1990 occurred in persons 60 years of age or older. Despite the fact that effective vaccines against tetanus have been available since the 1940s, many Americans do not have immunity to tetanus, and the rates are lowest among the elderly. There is an excellent correlation between vaccination rates (96%) and immunity (96%) among 6-year-olds. However, antibody levels decline over time, and one fifth of older children (10 to 16 years of age) do not have protective antibody levels. [An editorial by J.P. Sanford entitled "tetanus-forgotten but not gone" discusses tetanus immunization further.]
KW  - editorials
KW  - human diseases
KW  - immunity
KW  - immunization
KW  - immunization programmes
KW  - serological surveys
KW  - tetanus
KW  - vaccines
KW  - North America
KW  - USA
KW  - Clostridium tetani
KW  - man
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - bacterium
KW  - immune sensitization
KW  - immunization programs
KW  - lockjaw
KW  - seroepidemiology
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Human immunodeficiency virus.
AU  - Arthur, L. O.
AU  - Henderson, L. E.
AU  - Benveniste, R. E.
AU  - Phillips, D. M.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1995///
VL  - 332
IS  - 25
SP  - 1719
EP  - 1719
SN  - 0028-4793
AD  - Arthur, L. O.: National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19952009884.  Publication Type: Correspondence.  Language: English.  Number of References: 4 ref.
KW  - electron microscopy
KW  - envelope glycoproteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - membranes
KW  - proteins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009884&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Homocysteine metabolism in pregnancies complicated by neural-tube defects.
AU  - Mills, J. L.
AU  - McPartlin, J. M.
AU  - Kirke, P. N.
AU  - Lee, Y. J.
AU  - Conley, M. R.
AU  - Weir, D. G.
AU  - Scott, J. M.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1995///
VL  - 345
IS  - 8943
SP  - 149
EP  - 151
SN  - 0140-6736
AD  - Mills, J. L.: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19951412228.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 68-19-9, 59-30-3, 6027-13-0.  Subject Subsets: Human Nutrition
N2  - Folic acid taken around the time of conception can prevent many neural-tube defects. Women with low-normal vitamin B12 values may also be at increased risk. Whether homocysteine metabolism via the enzyme methionine synthase, which requires both folate and B12, could be the critical defect in folate-related neural tube defects was studied. Blood was obtained during pregnancies that produced 81 infants with neural-tube defects and 323 normal children. Samples were assayed for homocysteine, methylmalonic acid, plasma folate, red-cell folate, and B12. Mothers of children with neural-tube defects had significantly higher homocysteine values (8.62 μmol/litre) than did B12 matched controls (7.96 μmol/litre, P=0.03). The difference was significant (P=0.004) in the lower half of the B12 distribution after adjusting for plasma folate. Results show that an abnormality in homocysteine metabolism, apparently related to methionine synthase, is present in many women who give birth to children with neural-tube defects. Overcoming this abnormality is likely to be the mechanism by which folic acid prevents neural-tube defects. These findings suggest that the most effective periconceptional prophylaxis to prevent neural-tube defects may require B12 as well as folic acid.
KW  - cyanocobalamin
KW  - fetal development disorders
KW  - folic acid
KW  - homocysteine
KW  - infants
KW  - metabolism
KW  - pregnancy
KW  - prevention
KW  - supplements
KW  - vitamin b12
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cobalamin
KW  - foetal development disorders
KW  - folacin
KW  - folate
KW  - gestation
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene therapy and immune restoration for HIV disease.
AU  - Bridges, S. H.
AU  - Sarver, N.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1995///
VL  - 345
IS  - 8947
SP  - 427
EP  - 432
SN  - 0140-6736
AD  - Bridges, S. H.: Correspondence address: N. Sarver, Targeted Interventions Bramch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Building, Bethesda, MD 20898-7620, USA.
N1  - Accession Number: 19952002745.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref.
KW  - acquired immune deficiency syndrome
KW  - gene therapy
KW  - HIV infections
KW  - human diseases
KW  - immunity
KW  - immunopathology
KW  - treatment
KW  - vaccine development
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus infections
KW  - immunopathogenesis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002745&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Search for HIV-1 group O infection in Nigeria.
AU  - Dada, A. J.
AU  - Olumide, Y. M.
AU  - Henrard, D. R.
AU  - Phelps, B.
AU  - Pau, C. P.
AU  - Quinn, T. C.
AU  - Biggar, R. J.
AU  - O'Brien, T. R.
AU  - Blattner, W. A.
T2  - Lancet (British edition)
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1995///
VL  - 345
IS  - 8962
SP  - 1436
EP  - 1436
SN  - 0140-6736
AD  - Dada, A. J.: Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA.
N1  - Accession Number: 19952005814.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref.
KW  - acquired immune deficiency syndrome
KW  - aetiology
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Nigeria
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - AIDS
KW  - causal agents
KW  - etiology
KW  - group O infection
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005814&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment of HIV-associated Kaposi's sarcoma with paclitaxel.
AU  - Saville, M. W.
AU  - Lietzau, J.
AU  - Pluda, J. M.
AU  - Feuerstein, I.
AU  - Odom, J.
AU  - Wilson, W. H.
AU  - Humphrey, R. W.
AU  - Feigal, E.
AU  - Steinberg, S. M.
AU  - Broder, S.
AU  - Yarchoan, R.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1995///
VL  - 346
IS  - 8966
SP  - 26
EP  - 28
SN  - 0140-6736
AD  - Saville, M. W.: Correspondence address: Dr Robert Yarchoan, Building 10, Room 12N226, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952005990.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 33069-62-4. 
KW  - acquired immune deficiency syndrome
KW  - adverse effects
KW  - antineoplastic agents
KW  - dosage
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - opportunistic infections
KW  - paclitaxel
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - AIDS
KW  - cytotoxic agents
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - taxol
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Conjunctival malignant disease with AIDS in USA.
AU  - Goedert, J. J.
AU  - Coté, T. R.
T2  - Lancet (British edition)
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1995///
VL  - 346
IS  - 8969
SP  - 257
EP  - 258
SN  - 0140-6736
AD  - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19952007203.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref.
KW  - acquired immune deficiency syndrome
KW  - conjunctiva
KW  - eye diseases
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - melanoma
KW  - neoplasms
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cancers
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007203&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone.
AU  - Lunardi-Iskandar, Y.
AU  - Bryant, J. L.
AU  - Zeman, R. A.
AU  - Lam, V. H.
AU  - Samaniego, F.
AU  - Besnier, J. M.
AU  - Hermans, P.
AU  - Thierry, A. R.
AU  - Gill, P.
AU  - Gallo, R. C.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1995///
VL  - 375
IS  - 6526
SP  - 64
EP  - 68
SN  - 0028-0836
AD  - Lunardi-Iskandar, Y.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952004552.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 53321-48-5, 11130-48-6, 9002-61-3. 
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - chorionic gonadotropin
KW  - HIV infections
KW  - hormones
KW  - human diseases
KW  - kaposi's sarcoma
KW  - metastasis
KW  - neoplasms
KW  - pathogenesis
KW  - pregnancy
KW  - women
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - AIDS
KW  - cancers
KW  - choriogonadotropin
KW  - gestation
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004552&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection.
AU  - Wynn, T. A.
AU  - Cheever, A. W.
AU  - Jankovic, D.
AU  - Poindexter, R. W.
AU  - Caspar, P.
AU  - Lewis, F. A.
AU  - Sher, A.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1995///
VL  - 376
IS  - 6541
SP  - 594
EP  - 596
SN  - 0028-0836
AD  - Wynn, T. A.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19950807573.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Helminthology
N2  - It has previously been shown in mice that interleukin (IL)-12 administered peritoneally with schistosome eggs prevents subsequent pulmonary granuloma formation on intravenous challenge with eggs. It is now shown that sensitization with eggs plus IL-12 partly inhibits granuloma formation and dramatically reduces the tissue fibrosis induced by natural infection with Schistosoma mansoni worms. These results are an example of a vaccine against parasites which acts by preventing pathology rather than infection. IL-12 is known to favour the priming of Th1 rather than Th2 cells, and the effects on fibrosis are accompanied by replacement of the Th2-dominated pattern of cytokine expression characteristic of S. mansoni infection with one dominated by Th1 cytokines. Elevated Th2 cytokine expression and fibrosis are common manifestations of wide variety of infectious diseases and atopic disorders which might be ameliorated by vaccination with antigen and IL-12.
KW  - cytokines
KW  - experimental infections
KW  - fibrosis
KW  - helminths
KW  - human diseases
KW  - immunotherapy
KW  - interleukin 12
KW  - laboratory animals
KW  - parasites
KW  - schistosomiasis
KW  - vaccination
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Kaposi's sarcoma in pregnant women.
AU  - Rabkin, C. S.
AU  - Chibwe, G.
AU  - Muyunda, K.
AU  - Musaba, E.
AU  - Berger, P.
AU  - Dirnhofer, S.
AU  - Lunardi-Iskandar, Y.\Zeman, R. A.\Lam, V. H.\Samaniego, F.\Thierry, A. R.\Gallo, R. C.\Bryant, J. L.
T2  - Nature (London)
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1995///
VL  - 377
IS  - 6544
SP  - 21
EP  - 22
SN  - 0028-0836
AD  - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, EPN/434, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009182.  Publication Type: Correspondence.  Language: English.  Number of References: 20 ref.
KW  - hcg
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - kaposi's sarcoma
KW  - pregnancy
KW  - women
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gestation
KW  - human chorionic gonadotropin
KW  - human gonadotropic hormone
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - urogonadotropin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009182&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of apoptosis in mature T cells by tumour necrosis factor.
AU  - Zheng, L.
AU  - Fisher, G.
AU  - Miller, R. E.
AU  - Peschon, J.
AU  - Lynch, D. H.
AU  - Lenardo, M. J.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1995///
VL  - 377
IS  - 6545
SP  - 348
EP  - 351
SN  - 0028-0836
AD  - Zheng, L.: Correspondence address: M. J. Lenardo, Laboratory of Immunology, National Institite of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19952009608.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 308079-78-9. 
KW  - apoptosis
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - T lymphocytes
KW  - tumour necrosis factor
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - Fas ligand
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune system regulation
KW  - T cells
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Separation of tryptophan and related indoles by micellar electrokinetic chromatography with KrF laser-induced fluorescence detection.
AU  - Chan, K. C.
AU  - Muschik, G. M.
AU  - Issaq, H. J.
JO  - Journal of Chromatography
JF  - Journal of Chromatography
Y1  - 1995///
VL  - 718
IS  - 1
SP  - 203
EP  - 210
SN  - 0021-9673
AD  - Chan, K. C.: SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA.
N1  - Accession Number: 19961400383.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 73-22-3.  Subject Subsets: Human Nutrition
N2  - Micellar electrokinetic chromatography (MEKC) was applied for the separation of tryptophan and related indoles. Using a 5 mM sodium borate buffer (pH 9.2) containing 50 mM sodium dodecyl sulfate and 5% acetonitrile, 11 indoles were baseline separated in under 17 min. Most of the indoles were detected at the nM level by native fluorescence using KrF laser-induced fluorescence (LIF), which was about 100 times more sensitive than UV absorption detection at 200 nm. Preliminary results show that the MEKC-LIF with direct sample injection is a feasible method for assessing indole profiles in diluted urine and serum.
KW  - analytical methods
KW  - chromatography
KW  - detection
KW  - fluorescence
KW  - indoles
KW  - tryptophan
KW  - analytical techniques
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Pursuit of new leads to antitumour and anti-HIV agents from plants.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
A2  - K Hostettmann
A2  - A Marston
A2  - M Maillard
A2  - M Hamburger
T2  - Phytochemistry of plants used in traditional medicine
JO  - Phytochemistry of plants used in traditional medicine
JF  - Phytochemistry of plants used in traditional medicine
Y1  - 1995///
IS  - 37
SP  - 81
EP  - 93
CY  - Oxford; UK
PB  - Oxford University Press
SN  - 0198577753
AD  - Cardellina, J. H., II: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19962007857.  Publication Type: Miscellaneous.  Language: English.  Number of References: 28 ref.
KW  - development
KW  - drug therapy
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - chemotherapy
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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ER  - 

TY  - JOUR
T1  - The characteristics that differentiate Filobasidiella depauperata from Filobasidiella neoformans.
AU  - Kwon-Chung, K. J.
AU  - Chang, Y. C.
AU  - Bauer, R.
AU  - Swann, E. C.
AU  - Taylor, J. W.
AU  - Goel, R.
A2  - Boekhout, T.
A2  - Samson, R. A.
JO  - Studies in Mycology
JF  - Studies in Mycology
Y1  - 1995///
IS  - 38
SP  - 67
EP  - 79
CY  - Baarn; Netherlands
PB  - Centraalbureau voor Schimmelcultures (CBS)
SN  - 0166-0616
AD  - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200843.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 30 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The characteristics that differentiate F. depauperata and F. neoformans are discussed, including 18S ribosomal DNA sequences, ultrastructure of hyphal septa and nuclear division, life-cycles and biochemical characteristics.
KW  - identification
KW  - ribosomal DNA
KW  - taxonomy
KW  - techniques
KW  - ultrastructure
KW  - Cryptococcus neoformans
KW  - Filobasidiella
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus (Fungi)
KW  - Filobasidiella depauperata
KW  - Filobasidiella neoformans
KW  - fungus
KW  - Heterobasidiomycetes - systematics and applied aspects
KW  - systematics
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antifungal agents.
AU  - Bennett, J. E.
A2  - Mandell, G. L.
A2  - Bennett, J. E.
A2  - Dolin, R.
T2  - Mandell, Douglas and Bennett's principles and practice of infectious diseases. Volume 1.
Y1  - 1995///
IS  - Ed. 4
CY  - New York; USA
PB  - Churchill Livingstone
SN  - 0443089353
AD  - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Health and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19961202032.  Publication Type: Book chapter.  Language: English.  Number of References: 105 ref. Registry Number: 1397-89-3, 65-85-0, 86386-73-4, 2022-85-7, 84625-61-6, 65277-42-1, 69-72-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - Topical and systemic antifungal agents are discussed with the emphasis on pharmacology. Agents for cutaneous use such as salicylic and benzoic acids, allylamines, azoles, morpholine derivatives and polyenes; topical agents for vaginal use; oral therapy for superficial mycoses; and treatment of deep mycoses with amphotericin B, flucytosine, ketoconazole, itraconazole and fluconazole are considered.
KW  - amphotericin B
KW  - antifungal agents
KW  - azoles
KW  - benzoic acid
KW  - fluconazole
KW  - flucytosine
KW  - itraconazole
KW  - ketoconazole
KW  - mycoses
KW  - reviews
KW  - salicylic acid
KW  - therapy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 5-fluorocytosine
KW  - allylamines
KW  - fungistats
KW  - polyenes
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Strongyloides stercoralis.
AU  - Neva, F.
A2  - Farthing, M. J. G.
A2  - Keusch, G. T.
A2  - Wakelin, D.
T2  - Enteric infection 2: intestinal helminths.
JO  - Enteric infection 2: intestinal helminths.
JF  - Enteric infection 2: intestinal helminths.
Y1  - 1995///
SP  - 87
EP  - 105
CY  - London; UK
PB  - Chapman & Hall Ltd
SN  - 0412391406
AD  - Neva, F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19950807177.  Publication Type: Miscellaneous.  Language: English.  Number of References: 69 ref.
KW  - helminthoses
KW  - helminths
KW  - human diseases
KW  - strongyloidiasis
KW  - man
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Strongyloides
KW  - Strongyloididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antigenic variation in Giardia lamblia.
AU  - Nash, T. E.
A2  - Boothroyd, J. C.
A2  - Komuniecki, R.
T2  - Molecular approaches to parasitology.
Y1  - 1995///
CY  - New York; USA
PB  - Wiley-Liss, Inc.
SN  - 0471103411
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800031.  Publication Type: Book chapter.  Language: English.  Number of References: 51 ref. Subject Subsets: Protozoology
KW  - antigenic variation
KW  - molecular biology
KW  - molecular genetics
KW  - parasites
KW  - parasitology
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Immune responses in lymphatic-dwelling filarial infections.
AU  - Nutman, T. B.
A2  - Boothroyd, J. C.
A2  - Komuniecki, R.
T2  - Molecular approaches to parasitology.
Y1  - 1995///
CY  - New York; USA
PB  - Wiley-Liss, Inc.
SN  - 0471103411
AD  - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800061.  Publication Type: Book chapter.  Language: English.  Number of References: 48 ref. Subject Subsets: Helminthology
KW  - filariids
KW  - helminths
KW  - immune response
KW  - molecular biology
KW  - parasites
KW  - parasitology
KW  - man
KW  - onchocercidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800061&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Regulation of cell-mediated immunity by parasites: the ups and downs of an important host adaptation.
AU  - Sher, A.
A2  - Boothroyd, J. C.
A2  - Komuniecki, R.
T2  - Molecular approaches to parasitology.
Y1  - 1995///
CY  - New York; USA
PB  - Wiley-Liss, Inc.
SN  - 0471103411
AD  - Sher, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960800055.  Publication Type: Book chapter.  Language: English.  Number of References: 29 ref. Subject Subsets: Protozoology; Helminthology
KW  - helminths
KW  - molecular biology
KW  - parasites
KW  - parasitology
KW  - protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - immunoregulation
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800055&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Taxol®: science and applications.
A2  - Suffness, M.
T2  - Taxol®: science and applications.
Y1  - 1995///
CY  - Boca Raton; USA
PB  - CRC Press, Inc.
SN  - 084938382X
AD  - National Cancer Institute, National Insititutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19950316216.  Publication Type: Book.  Language: English.  Registry Number: 33069-62-4.  Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Forestry; Forest Products
N2  - This book, designed to be of interest to all those who wish to have a broad perspective on taxol research and development, discusses the supply, biology and chemistry of taxol, and the use of taxol in the treatment of breast and ovarian cancer. The book is divided into 14 chapters: (1) Discovery and development of taxol; (2) Yew and us: a brief history of the yew tree; (3) Taxus for taxol and taxoids; (4) Potential of plant cell culture for taxane production; (5) Semisynthesis of taxol and taxotere; (6) Toward the total synthesis of taxol and it analogues; (7) Biosynthesis of taxol; (8) Preclinical antitumour activity of taxanes; (9) Biopharmaceutics of paclitaxel (taxol): formulation, activity and pharmacokinetics; (10) The use of taxol in cell biology; (11) Detection and isolation; (12) Natural taxoids: structure and chemistry; (13) The medicinal chemistry of taxol; and (14) Taxol: clinical results and current issues in development. There is a subject index.
KW  - alkaloids
KW  - antineoplastic properties
KW  - biosynthesis
KW  - chemical structure
KW  - clinical trials
KW  - diterpenoid alkaloids
KW  - diterpenoids
KW  - in vitro culture
KW  - in vitro production
KW  - medicinal plants
KW  - medicinal properties
KW  - paclitaxel
KW  - pharmacokinetics
KW  - pharmacology
KW  - plant composition
KW  - synthesis
KW  - man
KW  - Taxaceae
KW  - Taxus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taxopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - Taxaceae
KW  - anti-neoplastic properties
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - taxol
KW  - Taxol: science and applications
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-wood Forest Products (KK540) 
KW  - in vitro Culture of Plant Material (FF170) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Technical advances in AIDS research in the human nervous system.
A2  - Major, E. O.
A2  - Levy, J. A.
T2  - Technical advances in AIDS research in the human nervous system.
Y1  - 1995///
CY  - New York; USA
PB  - Plenum Publishing Corporation
SN  - 0306450003
AD  - National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
N1  - Accession Number: 19962001958.  Publication Type: Book.  Language: English.  Number of References: ref.
KW  - acquired immune deficiency syndrome
KW  - brain
KW  - central nervous system
KW  - culture techniques
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - neurology
KW  - pathogenesis
KW  - proteins
KW  - toxins
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cerebrum
KW  - CNS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Structural features of the large subunit rRNA expressed in Plasmodium falciparum sporozoites that distinguish it from the asexually expressed large subunit rRNA.
AU  - Rogers, M. J.
AU  - Gutell, R. R.
AU  - Damberger, S. H.
AU  - Li Jun
AU  - McConkey, G. A.
AU  - Waters, A. P.
AU  - McCutchan, T. F.
JO  - RNA
JF  - RNA
Y1  - 1996///
VL  - 2
IS  - 2
SP  - 134
EP  - 145
AD  - Rogers, M. J.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970801518.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Protozoology
N2  - The 5.8S and 28S rRNAs from Plasmodium falciparum that are expressed in the sporozoite stage (S gene) of the parasites' life cycle in the mosquito host were identified and compared with transcripts expressed in the red blood cells (A gene) of the vertebrate host. This completes the first set of A- and S-type nuclear-encoded rRNA genes for a Plasmodium species. Analysis of the predicted secondary structures of the 2 units showed that most differences between the A- and S-type genes occur in regions previously known to be variable. However, the predicted secondary structure of both 28S rRNAs indicated 11 positions within conserved areas that are not typical of eukaryotic rRNAs. Although the A-type gene resembled almost all eukaryotes, being atypical in only 4 of the 11 positions, the S gene is variant in 8 of the 11 positions. In 3 of these positions, the S-type gene resembles the consensus nucleotides for the 23S rRNA from Eubacteria and/or Archaea. A few differences occur in regions associated with ribosome function, in particular the GTPase site where the S-type differs in a base pair and loop from all known sequences. Further, the identification of compensatory changes at conserved points of interactions between the 5.8S-28S rRNAs indicates that transcripts from A- and S-units should not be interchangeable.
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - ribosomal RNA
KW  - sporozoites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Application of molecular techniques to the diagnosis of microsporidial infection.
AU  - Fedorko, D. P.
AU  - Hijazi, Y. M.
JO  - Emerging Infectious Diseases
JF  - Emerging Infectious Diseases
Y1  - 1996///
VL  - 2
IS  - 3
SP  - 183
EP  - 191
AD  - Fedorko, D. P.: Clinical pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C-385, Bethesda, MD 20892-1508, USA.
N1  - Accession Number: 19960805117.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Protozoology
N2  - This short review of the diagnosis of microsporidial infection covers traditional diagnostic methods (transmission electron microscopy, light and fluorescent microscopy, cell culture, serology) and molecular techniques.
KW  - diagnosis
KW  - molecular genetics
KW  - parasites
KW  - reviews
KW  - man
KW  - Microspora
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Protozoa
KW  - invertebrates
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fusin - a place for HIV-1 and T4 cells to meet.
AU  - Dimitrov, D. S.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1996///
VL  - 2
IS  - 6
SP  - 640
EP  - 641
AD  - Dimitrov, D. S.: National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006870.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref.
KW  - binding sites
KW  - human diseases
KW  - t lymphocytes
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - binding site
KW  - fusin
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV integrase: a novel antiviral target.
AU  - Craigie, R.
JO  - International Antiviral News
JF  - International Antiviral News
Y1  - 1996///
VL  - 4
IS  - 2
SP  - 30
EP  - 32
SN  - 0965-2310
AD  - Craigie, R.: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002897.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibitors
KW  - integration
KW  - molecular biology
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - integrase
KW  - mechanism
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002897&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Obesity and risk of renal cell cancer.
AU  - Chow WongHo
AU  - McLaughlin, J. K.
AU  - Mandel, J. S.
AU  - Wacholder, S.
AU  - Niwa, S.
AU  - Fraumeni, J. F., Jr.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1996///
VL  - 5
IS  - 1
SP  - 17
EP  - 21
SN  - 1055-9965
AD  - Chow WongHo: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA.
N1  - Accession Number: 19962007851.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Human Nutrition; Public Health
N2  - In a population-based case-control study including 449 directly interviewed cases and 707 controls in Minnesota, USA, the risk of renal cell cancer associated with height, weight, body mass index (BMI), and frequency of weight changes was assessed. Odds ratios and 95% confidence intervals were estimated by using logistic regression models. Among women, risk increased with increasing usual BMI (P for trend &lt;0.001). A nearly 4-fold risk was found among the 10% of women with the highest usual BMI (odds ratio = 3.8; confidence interval = 1.7-8.4). Among men, no clear trend was observed with usual weight or BMI, although the highest risk (30-50%) generally was seen among those in the upper deciles of weight or BMI. There was no clear indication that excess BMI early or late in life disproportionately affected risk. Risk also was not related to patterns of weight fluctuations or use of diet pills. This study supports previous observations linking renal cell cancer risk to increased BMI among women and suggests a weaker association in men. Given the increasing prevalence of obesity and the rising incidence of renal cell cancer in the USA, additional studies are needed to disentangle the effects of BMI from various correlates and to identify the mechanisms by which obesity affects risk.
KW  - body mass index
KW  - human diseases
KW  - kidney cancer
KW  - kidneys
KW  - neoplasms
KW  - obesity
KW  - risk
KW  - risk factors
KW  - Minnesota
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lake States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancer sites
KW  - cancers
KW  - fatness
KW  - renal cancer
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007851&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary profiles and anti-oxidants in a rural population of central Italy with a low frequency of cancer.
AU  - Caperle, M.
AU  - Maiani, G.
AU  - Azzini, E.
AU  - Conti, E. M. S.
AU  - Raguzzini, A.
AU  - Ramazzotti, V.
AU  - Crespi, M.
JO  - European Journal of Cancer Prevention
JF  - European Journal of Cancer Prevention
Y1  - 1996///
VL  - 5
IS  - 3
SP  - 197
EP  - 206
SN  - 0959-8278
AD  - Caperle, M.: Section of Epidemiology, Regina Elena National Cancer Institute, Viale Regina Elena 291, 00161 Rome, Italy.
N1  - Accession Number: 19961406861.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 50-81-7, 104404-69-5, 9031-37-2, 68-26-8, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - This descriptive, cross-sectional study reports the antioxidant activities of 736 individuals, randomly selected from residents of 2 small towns of the Latina province of Italy (an area with low frequency of cancer). The circulating levels of vitamins A, C and E, ceruloplasmin, carotenoids (lutein + zeaxanthin, lycopene, α- and β-carotene, cryptoxanthin), cholesterol, HDL cholesterol and triglycerides, as well as anthropometric measurements (skin-folds, height, weight) were evaluated. A dietary interview was also performed by means of a semi-quantitative questionnaire. All the antioxidants were above the cut-off points for normality, whereas body mass index, % fat and serum lipids were not clearly suggestive of a protected population. The data obtained could be useful to estimate the baseline values of protective microelements and to assess dietary profiles in populations following a Mediterranean diet.
KW  - antioxidants
KW  - ascorbic acid
KW  - blood
KW  - blood lipids
KW  - carotenoids
KW  - ceruloplasmin
KW  - diet studies
KW  - incidence
KW  - neoplasms
KW  - retinol
KW  - vitamin E
KW  - Italy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - axerophthol
KW  - caeruloplasmin
KW  - cancers
KW  - tetraterpenoids
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406861&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Colorectal cancer and folate status: a nested case-control study among male smokers.
AU  - Glynn, S. A.
AU  - Albanes, D.
AU  - Pietinen, P.
AU  - Brown, C. C.
AU  - Rautalahti, M.
AU  - Tangrea, J. A.
AU  - Gunter, E. W.
AU  - Barrett, M. J.
AU  - Virtamo, J.
AU  - Taylor, P. R.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1996///
VL  - 5
IS  - 7
SP  - 487
EP  - 494
SN  - 1055-9965
AD  - Glynn, S. A.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 211, 9000 Rockville Pike, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19971404860.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref. Registry Number: 59-30-3.  Subject Subsets: Human Nutrition; Public Health
N2  - The relationship between folate status and colorectal cancer was examined in a case-control study nested within the Alpha-Tocopherol Beta-Carotene (ATBC) Study cohort of 29 133 male smokers in Finland, 50-69 years old, recruited between 1985 and 1988 and followed for 5-8 years. Serum folate was measured in 144 cases of colorectal cancer (91 colon, 53 rectum) occurring in 1985 through November 1993, identified from the Finnish cancer registry and 276 controls matched to cases on baseline age, clinic and time of blood collection. Baseline dietary folate was available from a food-use questionnaire for 386 of these men (92%). Conditional logistic regression modelling was used. Non-significant association was observed between serum folate and colon or rectal cancer. Although a 2-fold increase in rectal cancer risk was suggested for men with serum folate &gt;2.9 ng/ml and those in the highest quartile of energy-adjusted folate intake, there was no evidence of a monotonic dose-response and all confidence intervals included unity. For dietary folate and colon cancer, odds ratios (OR) of 0.40 (95% confidence interval (CI), 0.16-0.96), 0.34 (95% CI, 0.13-0.88), and 0.51 (95% CI, 0.20-1.31) were obtained for the second to fourth quartiles of energy-adjusted folate intake, respectively, compared to the first (P for trend=0.15). Furthermore, men with a high-alcohol, low folate, low-protein diet were at higher risk for colon cancer than men who consumed a low-alcohol, high-folate, high-protein diet (OR, 4.79; 95% CI, 1.36-16.93). This study suggests a possible association between low folate intake and increased risk of colon cancer (but not rectal cancer).
KW  - alcoholic beverages
KW  - blood
KW  - colon
KW  - colorectal cancer
KW  - diet studies
KW  - epidemiology
KW  - folic acid
KW  - intake
KW  - men
KW  - neoplasms
KW  - nutrition
KW  - nutritional state
KW  - protein intake
KW  - rectum
KW  - risk
KW  - risk factors
KW  - tobacco smoking
KW  - vitamins
KW  - Europe
KW  - Finland
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancer sites
KW  - cancers
KW  - folacin
KW  - folate
KW  - nutritional status
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404860&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk.
AU  - Dorgan, J. F.
AU  - Longcope, C.
AU  - Stephenson, H. E., Jr.
AU  - Falk, R. T.
AU  - Miller, R.
AU  - Franz, C.
AU  - Kahle, L.
AU  - Campbell, W. S.
AU  - Tangrea, J. A.
AU  - Schatzkin, A.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1996///
VL  - 5
IS  - 7
SP  - 533
EP  - 539
SN  - 1055-9965
AD  - Dorgan, J. F.: Divison of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19972003758.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 53-16-7.  Subject Subsets: Public Health
N2  - To evaluate the relation of serum sex hormones to breast cancer risk, a prospective nested case-control study was conducted using the Breast Cancer Serum Bank (Columbia, MO, USA). This bank included serum from 3375 postmenopausal women free of cancer and not taking replacement oestrogens when they donated blood between 1977 and 1987. Of these, 71 were diagnosed subsequently with breast cancer. For each case, 2 women alive and free of cancer at the age of the case's diagnosis and matched to the case on age and on date and time of day of blood collection were selected as controls. The median age of subjects at blood collection was 62 years, and the time from blood collection to diagnosis ranged from &lt;1 to 9.5 years, with a median of 2.9 years. Postmenopausal women with elevated serum levels of total and non-sex hormone-binding globulin-bound E2 were at an increased risk of developing breast cancer. For non-sex hormone-binding globulin-bound E2, risks were elevated 4-5 fold for women in the upper 3 quartiles relative to those in the lowest quartile. Although breast cancer was not related to oestrone or oestrone sulfate concentration, the ratio of oestrone sulfate to oestrone was significantly inversely associated with risk, suggesting that women who develop breast cancer may be less able to metabolize oestrone to its less active form. Serum testosterone was significantly positively associated with postmenopausal breast cancer; the relative risk for women in the highest vs. the lowest quartile was 6.2 (95% confidence interval, 2.0-19.0). These results support the hypothesis that prediagnostic serum oestrogens and androgens are related to the subsequent diagnosis of breast cancer in postmenopausal women.
KW  - blood donors
KW  - breast
KW  - breast cancer
KW  - diagnosis
KW  - estrone
KW  - human diseases
KW  - incidence
KW  - neoplasms
KW  - oestrogens
KW  - risk factors
KW  - serum
KW  - sex hormones
KW  - women
KW  - Missouri
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - estrogens
KW  - oestrol
KW  - oestrone
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003758&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Distribution of human leukocyte antigens in a population of black patients with human T-cell lymphotropic virus type I-associated adult T-cell leukemia/lymphoma.
AU  - White, J. D.
AU  - Johnson, J. A.
AU  - Nam, J.
AU  - Cranston, B.
AU  - Hanchard, B.
AU  - Waldmann, T. A.
AU  - Manns, A.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1996///
VL  - 5
IS  - 11
SP  - 873
EP  - 877
SN  - 1055-9965
AD  - White, J. D.: Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001178.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
N2  - The results of this pilot study indicate that black patients with adult T-cell leukaemia (ATL) may have increased frequencies of certain class I HLA when compared with a racially similar HTLV-I-positive reference population. This suggests that either these antigens may represent markers for a population at greater risk of developing ATL once infected in the process of malignant transformation or progression from the carrier state to onset of ATL. These antigens should be targeted in larger studies to confirm or refute these findings.
KW  - adult T-cell leukaemia
KW  - antigens
KW  - blacks
KW  - disease course
KW  - epidemiology
KW  - ethnic groups
KW  - htlv-i infections
KW  - malignant course
KW  - t lymphocytes
KW  - USA
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adult T-cell leukemia
KW  - antigenicity
KW  - disease progression
KW  - HTLV-BLV group
KW  - immunogens
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001178&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene therapy for AIDS.
AU  - Bunnell, B. A.
AU  - Morgan, R. A.
JO  - Molecules and Cells
JF  - Molecules and Cells
Y1  - 1996///
VL  - 6
IS  - 1
SP  - 1
EP  - 12
AD  - Bunnell, B. A.: Clinical Gene Therapy Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001075.  Publication Type: Journal Article.  Language: English.  Number of References: 111 ref.
N2  - The use of gene therapy for HIV-1 infection is reviewed, including the life cycle of HIV-1, nucleic acid- and protein-based gene therapy approaches. Anti-HIV gene therapy clinical trials, using transdominant negative proteins, ribozymes, antisense nucleic acids or single-chain antibodies, are discussed.
KW  - acquired immune deficiency syndrome
KW  - gene therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - therapy
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001075&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Seven-year trends in plasma low-density-lipoprotein-cholesterol in young adults: the CARDIA study.
AU  - Bild, D. E.
AU  - Jacobs, D. R. Jr.
AU  - Liu Kiang
AU  - Williams, O. D.
AU  - Hilner, J. E.
AU  - Perkins, L. L.
AU  - Marcovina, S. M.
AU  - Hulley, S. B.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1996///
VL  - 6
IS  - 3
SP  - 235
EP  - 245
SN  - 1047-2797
AD  - Bild, D. E.: National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961409655.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - To identify determinants of recent trends in blood lipid concentrations and characterize their influence on age-related increases in LDL-cholesterol, a cohort of black and white men and women aged 18-30 years in 1985-1986, from the USA were examined. Trends were assessed by comparing participants aged 25-30 years at baseline (1985-86) with those aged 25-30 years at year 7 (2788 and 1395 subjects, respectively). LDL-cholesterol was lower among those aged 25-30 years at year 7 (5.9 to 10.2 mg/100 ml depending on race-sex group; P&lt;0.001); weight was higher (8.3 to 12.5 lb; Pless than\0.001); Keys score was lower (-4.2 to -7.3 units; P&lt;0.001); and use of oral contraceptives was greater (white women only, P&lt;0.01). Among 4086 participants followed for 7 years, LDL-cholesterol changed little or decreased, despite substantial weight increases in all groups (11.6 to 19.0 lb; P&lt;0.001). Keys scores decreased by 6.1 to 8.0 units, and use of oral contraceptives decreased (P&lt;0.001). Declining trends in LDL-cholesterol occurred despite upward trends in weight; the decline was associated with lower fat and cholesterol intake and offset expected age-related increases in LDL-cholesterol.
KW  - adults
KW  - aging
KW  - blood lipids
KW  - body weight
KW  - cholesterol
KW  - diet
KW  - fats
KW  - food intake
KW  - low density lipoprotein
KW  - oral contraceptives
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - ageing
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961409655&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Virus-encoded zinc fingers as targets for antiviral chemotherapy.
AU  - Rice, W. G.
AU  - Turpin, J. A.
JO  - Reviews in Medical Virology
JF  - Reviews in Medical Virology
Y1  - 1996///
VL  - 6
IS  - 4
SP  - 187
EP  - 199
SN  - 1052-9276
AD  - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001508.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref.
N2  - A personal perspective is presented on the efforts to move the concept of retroviral zinc finger inhibitors toward practical application, and a historical perspective is provided of this emerging area of antiviral research. The clinical potential of zinc finger inhibitors in HIV-1 therapeutics is discussed.
KW  - antiviral agents
KW  - antiviral properties
KW  - drug targets
KW  - drug therapy
KW  - HIV infections
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - research
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anti-viral properties
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - other agents
KW  - studies
KW  - zinc finger inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001508&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer and comorbidity in older patients: a descriptive profile.
AU  - Yancik, R.
AU  - Havlik, R. J.
AU  - Wesley, M. N.
AU  - Ries, L.
AU  - Long, S.
AU  - Rossi, W. K.
AU  - Edwards, B. K.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1996///
VL  - 6
IS  - 5
SP  - 399
EP  - 412
SN  - 1047-2797
AD  - Yancik, R.: National Institute on Aging, National Institutes of Health, Building 31, Room 5C05, 31 Center Dr. MSC 2292, Bethesda, MD 20892-2292, USA.
N1  - Accession Number: 19972002122.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Public Health
N2  - In 1992, the National Institute on Aging (NIA) and the National Cancer Institute (NCI) in the USA initiated a study to assess the prevalence of comorbid conditions in elderly patients with cancer. Seven cancer sites were selected for the study: breast, cervix, ovary, prostate, colon, stomach, and urinary bladder. This report on around 7600 patients in the study sample describes the NIA/NCI approach to developing information on comorbidity in elderly patients and addresses the chronic disease burden (comorbidity) and severity for 6 particular conditions: arthritis, chronic obstructive pulmonary disease (COPD), diabetes, gastrointestinal problems, heart-related conditions, and hypertension. Data on comorbidity were collected by abstracting information from hospital medical records. Patients were registered in 6 geographical areas of the NCI Surveillance, Epidemiology, and End Results (SEER) Program. A stratified random sample of patients aged 55 to 64, 65 to 74, and 75 years or older with the index cancers were selected. Comorbidity data were matched with data from the conventional SEER monitoring system. Analyses showed that hypertension is the most prevalent condition and is also much more common as a current management problem rather than as history for the NIA/NCI SEER Study patients. Heart conditions varied slightly in the percentage of severity reported, but percentages for all tumours remained within a range of 13 to 26% for current and past categories. A similar range was observed for arthritis, with the higher percentage seen in the current problem category. For episodic complaints (e.g., gastrointestinal problems), a medical history was more common, except for cancers that involve complaints associated with the malignancy (e.g. colon and stomach cancers and, to a lesser extent, ovarian cancer). COPD and diabetes were less prevalent. Analyses currently under way will determine the impact of a patient's comorbidity burden on the cancer continuum of diagnosis, treatment, and survival. The broad and independent effects of chronic conditions, singly and in combination, are being examined.
KW  - arthritis
KW  - bladder
KW  - breast
KW  - breast cancer
KW  - cardiovascular diseases
KW  - cervical cancer
KW  - cervix
KW  - chronic course
KW  - colon
KW  - colorectal cancer
KW  - diabetes
KW  - elderly
KW  - epidemiology
KW  - gastrointestinal diseases
KW  - human diseases
KW  - hypertension
KW  - morbidity
KW  - neoplasms
KW  - ovaries
KW  - prostate
KW  - respiratory diseases
KW  - stomach
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - aged
KW  - breasts
KW  - cancers
KW  - comorbidity
KW  - elderly people
KW  - high blood pressure
KW  - lung diseases
KW  - older adults
KW  - senior citizens
KW  - United States of America
KW  - urinary bladder
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002122&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cardiovascular risk factors and hyperinsulinemia in elderly men: the Honolulu Heart Program.
AU  - Burchfiel, C. M.
AU  - Curb, J. D.
AU  - Arakaki, R.
AU  - Abbott, R. D.
AU  - Sharp, D. S.
AU  - Rodriguez, B. L.
AU  - Yano, K.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1996///
VL  - 6
IS  - 6
SP  - 490
EP  - 497
SN  - 1047-2797
AD  - Burchfiel, C. M.: Honolulu Heart Program, National Heart, Lung and Blood Institute, 347 North Kuakini Street, Honolulu, HI 96817, USA.
N1  - Accession Number: 19971402030.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Associations of cardiovascular risk factors, including several measures of adiposity, with hyperinsulinaemia were assessed in 3562 elderly (age 71-93 years) Japanese American men from the Honolulu Heart Program, Hawaii who were examined between 1991 and 1993. In addition, cardiovascular risk factors measured 25 years earlier were also examined in relation to hyperinsulinaemia. Hyperinsulinaemia was defined as fasting insulin ≥95th percentile (20 µU/ml) among the subset of subjects (n=504) who were nonobese and free of clinical diabetes and glucose intolerance. When this definition was applied to the entire population, the prevalence of hyperinsulinaemia declined cross-sectionally with age (P&lt;0.001) from 24.2% in men aged 71-74 years to 16.4% in men aged 85-93 years. Factors having a positive and independent association with hyperinsulinaemia included body mass index (BMI), triglycerides, glucose, haematocrit, use of diabetic medication, heart rate and hypertension. The association with physical activity was negative. Triglycerides, BMI, diabetic medication, hypertension, and smoking levels measured 25 years earlier were also associated independently with hyperinsulinaemia. Associations were similar in nondiabetic subjects. 3 measures of adiposity (BMI, waist circumference and subscapular skinfold thickness) were independently related to hyperinsulinaemia cross-sectionally. However, associations involving a difference between the 80th and 20th percentiles in each adiposity measure appeared strongest for BMI (odds ratio (OR), 4.5, 95% confidence interval (CI), 3.7-5.6) and waist circumference (OR, 4.1, 95% CI, 3.3-5.1) and slightly weaker for subscapular skinfold thickness (OR, 2.1, 95% CI, 1.8-2.5). These findings suggest that features of an insulin resistance syndrome including dyslipidaemia, glucose intolerance, hypertension and obesity, assessed cross-sectionally and 25 years previously, are associated independently with hyperinsulinaemia in elderly Japanese American men.
KW  - adipose tissue
KW  - anthropometric dimensions
KW  - arm circumference
KW  - blood
KW  - blood pressure
KW  - blood sugar
KW  - body measurements
KW  - cardiovascular diseases
KW  - diabetes
KW  - heart rate
KW  - hyperinsulinaemia
KW  - hypertension
KW  - insulin
KW  - men
KW  - obesity
KW  - old age
KW  - resistance
KW  - risk factors
KW  - skin fold thickness
KW  - triacylglycerols
KW  - Hawaii
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Polynesia
KW  - Oceania
KW  - Pacific Islands
KW  - anthropometric measurements
KW  - blood glucose
KW  - fatness
KW  - glucose in blood
KW  - high blood pressure
KW  - hyperinsulinemia
KW  - triglycerides
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrition and cervical neoplasia.
AU  - Potischman, N.
AU  - Brinton, L. A.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1996///
VL  - 7
IS  - 1
SP  - 113
EP  - 126
SN  - 0957-5243
AD  - Potischman, N.: Nutritional Epidemiology Section, Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961410610.  Publication Type: Journal Article.  Language: English.  Number of References: 79 ref. Registry Number: 50-81-7, 59-30-3, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - The relationship between nutritional factors and cervical neoplasia are reviewed under the headings: Introduction; Methodology; Ecologic studies; Retinoids; Carotenoids; Vitamin C; Vitamin E; Folate; Other nutritional factors; Summary and conclusions; Biologic plausibility; and Comment and future direction.
KW  - ascorbic acid
KW  - carotenoids
KW  - cervix
KW  - folic acid
KW  - neoplasms
KW  - nutrition
KW  - retinoids
KW  - reviews
KW  - vitamin E
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - folacin
KW  - folate
KW  - tetraterpenoids
KW  - vitamin A compounds
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410610&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutrition and lung cancer.
AU  - Ziegler, R. G.
AU  - Mayne, S. T.
AU  - Swanson, C. A.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1996///
VL  - 7
IS  - 1
SP  - 157
EP  - 177
SN  - 0957-5243
AD  - Ziegler, R. G.: Nutritional Epidemiology Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961410613.  Publication Type: Journal Article.  Language: English.  Number of References: 161 ref. Registry Number: 57-88-5, 59-30-3.  Subject Subsets: Human Nutrition
N2  - The relationship between dietary factors and lung cancer are reviewed under the headings: Introduction; Vitamin A and β-carotene - a historical perspective; Vegetables, fruits and carotenoids; Recent evidence; Generalizability of effect; Strength of association and population preventive fraction; Potential mechanisms; Antioxidant micronutrients; Folic acid; Total fat, saturated and cholesterol; Correlation studies; Retrospective studies; Prospective studies; Interpretation and potential mechanisms; Independence and interrelationships of dietary effects; Intervention trials; Historical perspective; Premalignant endpoints; Malignant endpoints; Interpretation of intervention trials; and Summary and conclusions.
KW  - antioxidants
KW  - carotenoids
KW  - cholesterol
KW  - diet
KW  - folic acid
KW  - fruit
KW  - lungs
KW  - neoplasms
KW  - nutrition
KW  - reviews
KW  - vegetables
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - folacin
KW  - folate
KW  - tetraterpenoids
KW  - vegetable crops
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410613&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Stability of HIV-1 RNA in blood samples from patients with HIV-1 infection as determined by a quantitative polymerase chain reaction-based assay.
AU  - Shirasaka, T.
AU  - Kojima, E.
AU  - Mitsuya, H.
T2  - Clinical and Diagnostic Virology
JO  - Clinical and Diagnostic Virology
JF  - Clinical and Diagnostic Virology
Y1  - 1996///
VL  - 7
IS  - 2
SP  - 121
EP  - 124
SN  - 0928-0197
AD  - Shirasaka, T.: The Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010033.  Publication Type: Correspondence.  Language: English.  Number of References: 15 ref. Registry Number: 63231-63-0. 
KW  - blood
KW  - HIV-1 infections
KW  - human diseases
KW  - patients
KW  - polymerase chain reaction
KW  - quantitative techniques
KW  - RNA
KW  - stability
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus type 1
KW  - PCR
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiviral immunity in HIV-1 infected long-term non-progressors (LTNPs).
AU  - Pantaleo, G.
AU  - Vaccarezza, M.
AU  - Graziosi, C.
AU  - Cohen, O. J.
AU  - Fauci, A. S.
JO  - Seminars in Virology
JF  - Seminars in Virology
Y1  - 1996///
VL  - 7
IS  - 2
SP  - 131
EP  - 138
SN  - 1044-5773
AD  - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007696.  Publication Type: Journal Article.  Language: English. 
N2  - Now that the acquired immunodeficiency syndrome (AIDS) epidemic is well into its second decade, it has become evident that a small percentage (approximately 5%) of HIV-infected individuals do not experience progression of HIV disease even after several years of being infected with HIV. These individuals have been designated as 'long term non-progressors' (LTNPs). From a virologic standpoint, these LTNPs have low viral burden in mononuclear cells, but persistent virus replication as manifested by chronic and generally low levels of plasma viremia. From an immunologic standpoint, immune functions including CD8+ T-cell- and CD4+ T-cell-mediated functions are preserved. In addition, they show a vigorous humoral immune response. More importantly, lymphoid tissue structure and function are preserved in LTNPs. Despite persistent low-level virus replication and chronic stimulation of the immune system, immune activation is qualitatively and quantitatively different in LTNPs compared to that observed in HIV-infected individuals whose HIV disease has progressed.
KW  - disease course
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - replication
KW  - viral load
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - nonprogressors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Childhood exposure to magnetic fields: residential area measurements compared to personal dosimetry.
AU  - Friedman, D. R.
AU  - Hatch, E. E.
AU  - Tarone, R.
AU  - Kaune, W. T.
AU  - Kleinerman, R. A.
AU  - Wacholder, S.
AU  - Boice, J. D., Jr.
AU  - Linet, M. S.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1996///
VL  - 7
IS  - 2
SP  - 151
EP  - 155
SN  - 1044-3983
AD  - Friedman, D. R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
N1  - Accession Number: 19962008851.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref.
N2  - This study examined the relation between area measurements of residential magnetic fields and personal dosimetry measurements among 64 control children aged 2-14 years from the US National Cancer Institute-Children's Cancer Group's 9 state case control study of childhood leukaemia. Children spent &gt;40% of the 24 hours of weekdays in their bedrooms, and 68% of their time at home. At-home personal dosimetry levels were highly correlated with total personal dosimetry levels in children under 9 years (Spearman correlation coefficient, R = 0.94), whereas the correlation was lower in older children (R = 0.59). For all children combined, bedroom 24-hour measurements correlated well with at-home personal dosimetry levels (R = 0.76). It is concluded that the 24-hour bedroom measurement was a useful predictor of both at-home and total personal dosimetry measurements. These data suggest, particularly for younger children, that in-home area measurements predict both current residential and current total magnetic field exposures.
KW  - children
KW  - electromagnetic radiation
KW  - exposure
KW  - leukaemia
KW  - measurement
KW  - neoplasms
KW  - radiation
KW  - toxicology
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - blood cancer
KW  - cancers
KW  - leucaemia
KW  - leukemia
KW  - metrology
KW  - United States of America
KW  - Human Health and the Environment (VV500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008851&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of diet and antihypertensive therapy on creatinine clearance and serum creatinine concentration in the Modification of Diet in Renal Disease Study.
JO  - Journal of the American Society of Nephrology
JF  - Journal of the American Society of Nephrology
Y1  - 1996///
VL  - 7
IS  - 4
SP  - 556
EP  - 566
SN  - 1046-6673
AD  - National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19971409329.  Publication Type: Journal Article.  Corporate Author: USA, Modification of Diet in Renal Disease Study Group Language: English.  Number of References: 35 ref. Registry Number: 60-72-5.  Subject Subsets: Human Nutrition
N2  - The effect of dietary protein and antihypertensive therapy on creatinine (Cr) clearance (Ccr) and serum creatinine concentration (Pcr) was assessed in patients participating in the Modification of Diet in Renal Disease (MDRD) Study. This study compared the effects of assignment to a low vs. usual-protein diet and to a low vs. usual-blood pressure goal on the decline in these measurements over 3 years in 585 patients with baseline glomerular filtration rate (GFR) of 25-55 ml/min per 1.73 m² (study A). It also assessed correlations and associations of these measurements with each other and with protein intake, blood pressure, class of antihypertensive agents, and renal diagnosis in 840 patients with baseline GFR of 13-55 ml/min per 1.73 m² (studies A and B). In study A, the estimated mean decline in GFR at 3 years did not differ between the low and usual-protein diet groups. However, Cr clearance from tubular secretion (CTScr) declined more in the low-protein diet group (P&lt;0.05). Consequently, the low-protein diet group had a greater decline in Ccr (P&lt;0.05). The low-protein diet group also had a greater decline in Cr excretion (UcrV) (P&lt;0.05). The decline in UcrV was proportionately greater than the decline in CTScr, hence the decline in the reciprocal of Pcr (1/Pcr) was less in the low-protein diet group. In study A, there was no significant difference in the decline in GFR at 3 years between the low and usual-blood pressure groups. However, there was a lesser decline in CTScr in the low blood pressure group (P&lt;0.05). Consequently, the decline in Ccr was less in the low blood pressure group (P&lt;0.05). There was no significant difference in UcrV between the blood pressure groups. Hence, the decline in 1/Pcr paralleled the decline in Ccr; it was less in the low blood pressure group (P&lt;0.05). In studies A and B, correlations of rates of decline in Ccr and GFR were 0.64 and 0.79, respectively (P&lt;0.001). Correlations of rates of decline in 1/Pcr and GFR were 0.79 and 0.85, respectively (P&lt;0.001). In studies A and B combined, baseline GFR, CTScr and UcrV correlated significantly with protein intake (r = 0.45, 0.47 and 0.36, respectively; P&lt;0.001), but not with blood pressure. Baseline CTScr was significantly lower in patients with polycystic kidney disease and tubulointerstitial diseases or urinary tract diseases, compared with glomerular and other diseases (P&lt;0.05). It was also lower in patients who were taking calcium channel blockers, compared with patients not taking these agents, and in patients not taking diuretics, compared with patients taking diuretics (P&lt;0.05). It is concluded that Cr secretion and excretion are affected by protein intake.
KW  - antihypertensive agents
KW  - blood pressure
KW  - creatinine
KW  - excretion
KW  - glomerular filtration rate
KW  - kidney diseases
KW  - protein intake
KW  - renal function
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - kidney disorders
KW  - kidney function
KW  - nephropathy
KW  - renal diseases
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409329&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Factors associated with disclosure of diagnosis to children with HIV/AIDS.
AU  - Wiener, L. S.
AU  - Battles, H. B.
AU  - Heilman, N.
AU  - Sigelman, C. K.
AU  - Pizzo, P. A.
JO  - Pediatric AIDS and HIV Infection
JF  - Pediatric AIDS and HIV Infection
Y1  - 1996///
VL  - 7
IS  - 5
SP  - 310
EP  - 324
SN  - 1045-5418
AD  - Wiener, L. S.: Pediatric Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972000107.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
N2  - Factors that affect the process of disclosure of AIDS and its consequences were studied in 99 parent-child dyads from the USA. Parents and HIV-infected children were interviewed and administered several standardized measures. Parental depression, family environment, social support satisfaction, socioeconomic status, child and parent gender, child's age, parental HIV serostatus and disease severity were used to predict disclosure status. Results indicated that the majority of caregivers do disclose the diagnosis to the child, usually with no ill-effects, and that age is the most significant predictor of whether or not a child has been told.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - counselling
KW  - diagnosis
KW  - health care
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - social welfare
KW  - sociology
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - counseling
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - social aspects
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000107&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Drinking water nitrate and the risk of non-Hodgkin's lymphoma.
AU  - Ward, M. H.
AU  - Mark, S. D.
AU  - Cantor, K. P.
AU  - Weisenburger, D. D.
AU  - Correa-Villaseñor, A.
AU  - Zahm, S. H.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1996///
VL  - 7
IS  - 5
SP  - 465
EP  - 471
SN  - 1044-3983
AD  - Ward, M. H.: Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, National Cancer Institute, 6130 Executive Boulevard, EPN-418, Bethesda, MD 20892-7364, USA.
N1  - Accession Number: 19971409267.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 14797-55-8, 50-81-7, 7727-37-9.  Subject Subsets: Human Nutrition; Public Health
N2  - The association between drinking water contaminated with nitrates and non-Hodgkin's Lymphoma (NHL), after accounting for dietary nitrate intake, was evaluated in 156 cases and 527 controls, in rural Nebraska, USA, between 1947 and 1979. Long-term consumption of community water with average nitrate levels in the highest quartile (≥4 mg/litre nitrate-nitrogen) was positively associated with risk (odds ratio (OR)=2.0; 95% confidence interval (CI)=1.1-3.6). Dietary nitrate, which came mainly from vegetables, was not associated with NHL risk, after adjusting for vitamin C [ascorbic acid] and carotene intakes. Persons with a lower intake of vitamin C were at slightly higher risk of developing NHL than persons whose daily intake was ≥130 mg, for all levels of intake of drinking water nitrate. Similar effects were observed for the combined effect of water nitrate and carotene intake. Nitrate levels in private wells were measured at the time of the interview for 51 cases and 150 controls but were not associated with the risk of NHL, after adjusting for pesticide use on the farm. It is concluded that long-term exposure to elevated nitrate levels in drinking water may increase the risk of NHL.
KW  - ascorbic acid
KW  - contamination
KW  - drinking water
KW  - men
KW  - nitrate
KW  - nitrates
KW  - nitrogen
KW  - non-hodgkin's lymphoma
KW  - toxicology
KW  - vegetables
KW  - women
KW  - Nebraska
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Northern Plains States of USA
KW  - West North Central States of USA
KW  - North Central States of USA
KW  - United States of America
KW  - vegetable crops
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body composition in clinically stable men with HIV infection.
AU  - Grady, C.
AU  - Ropka, M.
AU  - Anderson, R.
AU  - Lane, H. C.
JO  - Journal of the Association of Nurses in AIDS Care
JF  - Journal of the Association of Nurses in AIDS Care
Y1  - 1996///
VL  - 7
IS  - 6
SP  - 29
EP  - 38
AD  - Grady, C.: Clinical Therapeutics Laboratory, National Institute of Nursing Research, NIH, Bethesda, MD, USA.
N1  - Accession Number: 19972002230.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - Clinically stable HIV-infected men (n=106) receiving investigational antiretrovirals were recruited. Subjects were divided into 3 HIV disease severity groups by CD4+ cell count. Standard measures of body composition were assessed, as well as serum measures of visceral protein stores and kilocalorie intake. Group 1 subjects (CD4+ T cells &gt;200) had significantly lower measures of body fat compared with Group 2 (CD4+ between 200 and 600) and Group 3 (CD4+ &gt;600) despite adequate kilocalorie intake. Group 2 and Group 3 were not significantly different from each other. The entire cohort had significantly lower muscle mass compared to norms. It is concluded that people with advanced HIV disease have reduced muscle and fat.
KW  - body parts
KW  - clinical aspects
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - men
KW  - muscles
KW  - nutrition
KW  - T lymphocytes
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Combination chemotherapy for advanced bilharzial bladder carcinoma.
AU  - Khaled, H. M.
AU  - El-Mawla, N. G.
AU  - El-Said, A.
AU  - Hamza, M. R.
AU  - Gaafar, R.
AU  - El-Attar, I.
AU  - Rabia, A. A.
AU  - Magrath, I.
JO  - Annals of Oncology
JF  - Annals of Oncology
Y1  - 1996///
VL  - 7
IS  - 7
SP  - 751
EP  - 754
SN  - 0923-7534
AD  - Khaled, H. M.: Department of Medical Oncology, National Cancer Institute, Cairo, Egypt.
N1  - Accession Number: 19970800396.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Registry Number: 57-22-7.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Carcinoma of the bilharzial bladder, the most common cancer in Egyptian patients, is usually treated by surgery. Therapeutic combinations of identified active agents were administered in alternating cycles to patients who had not previously received chemotherapy. The study included 30 patients with inoperable disease (20), recurrent disease (5, 2 of whom subsequently developed metastases) or metastatic disease (5). There were 27 males and 3 females, with a median age of 48.5 years (range 29-65 years). Fourteen patients had squamous cell carcinoma, 12 had transitional cell carcinoma, 2 had adenocarcinoma and 2 had undifferentiated carcinoma. Chemotherapy consisted of epidoxorubicin (120 mg/sqm i.v., day 1) and vincristine (1.4 mg/sqm i.v., days 1 and 8), alternating with etoposide (100 mg/sqm i.v. infusion over 1 h, days 1 to 5) and ifosfamide (1800 mg/sqm i.v. infusion over 2 h, days 1 to 5). Mesna was given as a uroprotector at 40% of the ifosfamide dose at 0, 4 and 8 h after the ifosfamide infusion. Courses were repeated every 3-4 weeks. Among the 22 evaluable patients, 8 (36.5%) had a partial and 1 (4.5%) had a complete response, giving a response rate of 46%. Three more patients had responses that were less than a partial remission,and 6 patients showed disease stabilisation. Toxicities were tolerable and consisted mainly of myelosuppression. Results were further analysed in relation to pathological subtype, disease status at the start of chemotherapy and the delivered dose intensity. No relationship was found between any of these parameters and response to therapy. Advanced bilharzial bladder cancer appears to be relatively sensitive to combination chemotherapy, but complete remission and prolonged survival is rare in patients with advanced disease.
KW  - bladder
KW  - bladder cancer
KW  - bladder diseases
KW  - drug combinations
KW  - drug therapy
KW  - drug toxicity
KW  - helminths
KW  - human diseases
KW  - neoplasms
KW  - parasites
KW  - schistosomiasis
KW  - vincristine
KW  - Africa
KW  - Egypt
KW  - man
KW  - Schistosoma haematobium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - bilharzia
KW  - bilharziasis
KW  - cancer sites
KW  - cancers
KW  - chemotherapy
KW  - epidoxorubicin
KW  - etoposide
KW  - ifosfamide
KW  - mesna
KW  - Misr
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - urinary bladder
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR.
AU  - Kitareewan, S.
AU  - Burka, L. T.
AU  - Tomer, K. B.
AU  - Parker, C. E.
AU  - Deterding, L. J.
AU  - Stevens, R. D.
AU  - Forman, B. M.
AU  - Mais, D. E.
AU  - Heyman, R. A.
AU  - McMorris, T.
AU  - Weinberger, C.
JO  - Molecular Biology of the Cell
JF  - Molecular Biology of the Cell
Y1  - 1996///
VL  - 7
IS  - 8
SP  - 1153
EP  - 1166
SN  - 1059-1524
AD  - Kitareewan, S.: Orphan Receptor Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
N1  - Accession Number: 19961408846.  Publication Type: Journal Article.  Language: English.  Number of References: 88 ref. Registry Number: 1406-65-1.  Subject Subsets: Human Nutrition
N2  - RXR is a nuclear receptor that plays a central role in cell signalling by pairing with a host of other receptors. Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR activator. Here a unique RXR effector is described, identified from organic extracts of bovine serum by following RXR-dependent transcriptional activity. Structural analyses of material in active fractions pointed to the saturated diterpenoid phytanic acid, which induced RXR-dependent transcription at concentrations between 4 and 64 µM. Although 200 times more potent than phytanic acid, 9cRA was undetectable in equivalent amounts of extract and cannot be present at a concentration that could account for the activity. Phytenic acid, another phytol metabolite, was synthesized and stimulated RXR with a potency and efficacy similar to phytanic acid. These metabolites specifically displaced [³H]-9cRA from RXR with Ki values of 4 µM, indicating that their transcriptional effects are mediated by direct receptor interactions. Phytol metabolites are compelling candidates for physiological effectors, because their RXR binding affinities and activation potencies match their micromolar circulating concentrations. Given their exclusive dietary origin, these chlorophyll metabolites may represent essential nutrients that coordinate cellular metabolism through RXR-dependent signalling pathways.
KW  - cell cultures
KW  - chlorophyll
KW  - diet
KW  - gene expression
KW  - metabolites
KW  - plant products
KW  - transcription factors
KW  - crop products
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of dietary protein restriction on the progression of moderate renal disease in the Modification of Diet in Renal Disease Study.
JO  - Journal of the American Society of Nephrology
JF  - Journal of the American Society of Nephrology
Y1  - 1996///
VL  - 7
IS  - 12
SP  - 2616
EP  - 2626
SN  - 1046-6673
AD  - National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19971408650.  Publication Type: Journal Article.  Corporate Author: USA, Modification of Diet in Renal Disease Study Group Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - 585 patients were given a low-protein diet (LPD; 0.58 g/kg daily) or a normal diet (1.3 g/kg day). The comparisons of randomized groups revealed a faster glomerular filtration rate (GFR) decline during the first 4 months of the LPD but no difference in the variability in GFR decline between the diet groups, indicating a uniform short-term effect of the LPD on GFR, probably as a result of haemodynamic adjustments. After 4 months, the mean decline in GFR in the LPD group was slower, and the variability of the rate of decline was smaller, than in the normal diet group. This suggests a greater beneficial effect of the LPD in patients with a more rapid GFR decline. Over 3 years LPD caused no significant change in mean GFR decline, but reduced the variability of the decline. Correlational analyses revealed trends similar to the comparisons of randomized groups. During the first 4 months, patients with a greater decline in protein intake (irrespective of diet group) had a greater decline in GFR; thereafter, LPD patients had a slower GFR decline. Over 3 years, there was no significant correlation between GFR decline and achieved protein intake. The relative risk of death or renal failure was 0.65 (95% CI 0.38-1.10; P=0.10) in patients assigned to the LPD group compared with the normal diet group. During follow-up, the increase in urine protein excretion was delayed in the LPD group (P=0.008) and in patients with lower achieved protein intake (P=0.005). The results provide some support for the hypothesis that dietary protein restriction slows the progression of moderate renal disease.
KW  - excretion
KW  - glomerular filtration rate
KW  - haemodynamics
KW  - kidney diseases
KW  - protein deprivation
KW  - protein intake
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hemodynamics
KW  - kidney disorders
KW  - nephropathy
KW  - renal diseases
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation.
AU  - Tian, H.
AU  - Lempicki, R.
AU  - King, L.
AU  - Donoghue, E.
AU  - Samelson, L. E.
AU  - Cohen, D. I.
JO  - International Immunology
JF  - International Immunology
Y1  - 1996///
VL  - 8
IS  - 1
SP  - 65
EP  - 74
SN  - 0953-8178
AD  - Tian, H.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006421.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
KW  - CD4+ lymphocytes
KW  - cytopathogenicity
KW  - envelope proteins
KW  - enzymes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - killing
KW  - protein tyrosine kinases
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - HIV causes AIDS: Koch's postulates fulfilled.
AU  - O'Brien, S. J.
AU  - Goedert, J. J.
T2  - Current Opinion in Immunology
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1996///
VL  - 8
IS  - 5
SP  - 613
EP  - 618
SN  - 0952-7915
AD  - O'Brien, S. J.: National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972004850.  Publication Type: Editorial.  Language: English.  Number of References: 84 refs.
N2  - The debate over whether HIV causes AIDS is discussed; epidemiological association, isolation of pathogen from AIDS patients and transmission pathogenesis in animal models or in man are considered.
KW  - acquired immune deficiency syndrome
KW  - disease transmission
KW  - epidemiology
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The use of oral fluid to determine HIV-1 prevalence rates among men in Mexico City.
AU  - Rio, C. del
AU  - Guarner, J.
AU  - Izazola-Licea, J. A.
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1996///
VL  - 10
IS  - 2
SP  - 233
EP  - 235
SN  - 0269-9370
AD  - Rio, C. del: CONASIDA, National AIDS Council, National Cancer Institute, Mexico City, Mexico.
N1  - Accession Number: 19962002582.  Publication Type: Correspondence.  Language: English.  Number of References: 11 ref.
KW  - ELISA
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - laboratory methods
KW  - saliva
KW  - serological surveys
KW  - testing
KW  - Mexico
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - North America
KW  - OECD Countries
KW  - Threshold Countries
KW  - enzyme linked immunosorbent assay
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - laboratory techniques
KW  - salivary secretions
KW  - seroepidemiology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Altered brain fyn kinase in a murine acquired immunodeficiency syndrome.
AU  - Sei, Y.
AU  - Whitesell, L.
AU  - Kustova, Y.
AU  - Paul, I. A.
AU  - Morse, H. C., III
AU  - Skolnick, P.
AU  - Basile, A. S.
JO  - FASEB Journal
JF  - FASEB Journal
Y1  - 1996///
VL  - 10
IS  - 2
SP  - 339
EP  - 344
SN  - 0892-6638
AD  - Sei, Y.: Labroratory of Neuroscience, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19962003782.  Publication Type: Journal Article.  Language: English.  Registry Number: 60-18-4. 
KW  - acquired immune deficiency syndrome
KW  - brain
KW  - dementia
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunological deficiency
KW  - phosphorylation
KW  - tyrosine
KW  - Denmark
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - AIDS
KW  - cerebrum
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune deficiency
KW  - immunodeficiency
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells.
AU  - Horn, V.
AU  - Minucci, S.
AU  - Ogryzko, V. V.
AU  - Adamson, E. D.
AU  - Howard, B. H.
AU  - Levin, A. A.
AU  - Ozato, K.
JO  - FASEB Journal
JF  - FASEB Journal
Y1  - 1996///
VL  - 10
IS  - 9
SP  - 1071
EP  - 1077
SN  - 0892-6638
AD  - Horn, V.: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19961408113.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - In P19 embryonic carcinoma cells, characteristic DNA fragmentation was observed within 36 h after addition of retinoic acid (RA). Synthetic retinoids that were selective for RA receptors (RAR) were also effective in inducing apoptosis, whereas retinoid X receptor (RXR) selective ligands were without effect. The combination of RAR and RXR ligands resulted in a synergistic increase in apoptotic cell death. As with apoptosis, neuronal differentiation of P19 cells was synergistically induced by the combination of RAR and RXR ligands. Data obtained with an RAR antagonist and with P19 cells carrying a dominant negative RXR indicate that the 2 processes are receptor mediated. Together, the results indicate that retinoid-induced apoptosis and neuronal differentiation are closely coupled, and that RAR and RXR play a role in these processes as active receptors for their respective ligands.
KW  - apoptosis
KW  - carcinoma
KW  - cell cultures
KW  - cell growth
KW  - cells
KW  - development
KW  - differentiation
KW  - embryos
KW  - ligands
KW  - neoplasms
KW  - receptors
KW  - retinoic acid
KW  - retinoids
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cell elongation
KW  - tretinoin
KW  - vitamin A acid
KW  - vitamin A compounds
KW  - Human Reproduction and Development (VV060) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Potential heterosexual Kaposi's sarcoma-associated herpesvirus transmission in a couple with HIV-induced immunodepression and with Kaposi's sarcoma and multicentric Castleman's disease.
AU  - Tirelli, U.
AU  - Gaidano, G.
AU  - Errante, D.
AU  - Carbone, A.
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1996///
VL  - 10
IS  - 11
SP  - 1291
EP  - 1304
SN  - 0269-9370
AD  - Tirelli, U.: Division of Medical Oncology and AIDS, CRO National Cancer Institute, Aviano, Italy.
N1  - Accession Number: 19972000636.  Publication Type: Correspondence.  Language: English.  Number of References: 2 ref.
KW  - acquired immune deficiency syndrome
KW  - aetiology
KW  - heterosexuality
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunological deficiency
KW  - Kaposi's sarcoma
KW  - transmission
KW  - Human herpesvirus 8
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - Castleman's disease
KW  - causal agents
KW  - etiology
KW  - heterosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune deficiency
KW  - immunodeficiency
KW  - Kaposi's sarcoma-associated herpesvirus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Marital status in relation to Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal cancer in the pre-AIDS era.
AU  - Biggar, R. J.
AU  - Melbye, M.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 11
IS  - 2
SP  - 178
EP  - 182
AD  - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962003481.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
KW  - acquired immune deficiency syndrome
KW  - anus
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cancers
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Examining the molecular genetics of HTLV-I with an infectious molecular clone of the virus and permissive cell culture systems.
AU  - Derse, D.
AU  - Mikovits, J.
AU  - Waters, D.
AU  - Brining, S.
AU  - Ruscetti, F.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 12
IS  - 1
SP  - 1
EP  - 5
AD  - Derse, D.: Laboratory of Leukocyte Biology, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19962006053.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
KW  - HTLV-I infections
KW  - human diseases
KW  - molecular biology
KW  - pathogenesis
KW  - T lymphocytes
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006053&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype.
AU  - Bhattacharyya, D.
AU  - Brooks, B. R.
AU  - Callahan, L.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 2
SP  - 83
EP  - 90
SN  - 0889-2229
AD  - Bhattacharyya, D.: Laboratory of Structural Biology, Division of Computer Research and Technology, National Institutes of Health, Bldg. 12A, Room 2041, 12 South Drive MSC 5626, Bethesda, MD 20892-5626, USA.
N1  - Accession Number: 19962003554.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref.
KW  - envelope protein gp120
KW  - HIV-1 infections
KW  - human diseases
KW  - pathogenesis
KW  - phenotypes
KW  - syncytia
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gp120
KW  - human immunodeficiency virus type 1
KW  - V3 loop
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV type 1 nef perturbs eye lens development in transgenic mice.
AU  - Dickie, P.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 3
SP  - 177
EP  - 189
SN  - 0889-2229
AD  - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19962003710.  Publication Type: Journal Article.  Language: English.  Number of References: 76 ref.
KW  - animal models
KW  - eye diseases
KW  - eye lens
KW  - HIV-1 infections
KW  - human diseases
KW  - Nef protein
KW  - pathogenesis
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003710&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic T cells, and neutralizing antibody, all using the same adjuvant immunization.
AU  - Ahlers, J. D.
AU  - Dunlop, N.
AU  - Pendleton, C. D.
AU  - Newman, M.
AU  - Nara, P. L.
AU  - Berzofsky, J. A.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 4
SP  - 259
EP  - 272
SN  - 0889-2229
AD  - Ahlers, J. D.: Molecular Immunogenetics and Vaccine Research Section Metabolism Branch, National Cancer Institute, National Institute of Health (NIH), Bethesda, MD 20892, USA.
N1  - Accession Number: 19962004663.  Publication Type: Journal Article.  Language: English.  Number of References: 72 ref.
KW  - adjuvants
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - man
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004663&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Attenuated poxvirus vectors as carriers in vaccines against human T cell leukemia-lymphoma virus type I.
AU  - Franchini, G.
AU  - Benson, J.
AU  - Gallo, R.
AU  - Paoletti, E.
AU  - Tartaglia, J.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 5
SP  - 407
EP  - 408
SN  - 0889-2229
AD  - Franchini, G.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972002605.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref.
N2  - The development of a vaccine against human t-cell lymphotropic virus type I using attenuated poxvirus vectors is discussed.
KW  - htlv-i infections
KW  - human diseases
KW  - vaccines
KW  - vectors
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - HTLV-BLV group
KW  - poxvirus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002605&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell lymphotropic virus type I infection in Barbados: results of a 20-year follow-up study.
AU  - Rabkin, C. S.
AU  - Corbin, D. O. C.
AU  - Felton, S.
AU  - Barker, H.
AU  - Davison, D.
AU  - Dearden, C.
AU  - Blattner, W. A.
AU  - Evans, A. S.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 12
IS  - 5
SP  - 519
EP  - 522
AD  - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN/434, Rockville, MD 20852, USA.
N1  - Accession Number: 19962008000.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Tropical Diseases
N2  - Forty-one human T-cell lymphotropic virus type I (HTLV-I)-seropositive individuals were identified among 1012 subjects with stored serum samples from a health and seroepidemiological survey conducted in Barbados in 1972. These 41 subjects plus 79 HTLV-I-seronegative household members were targeted in a follow-up study 20 years later. Sixteen seropositive subjects and 22 seronegative subjects were interviewed, examined, and phlebotomized. There were no changes in HTLV-I serostatus between the 1972 and follow-up serum samples. Three (19%) of the seropositive subjects had HTLV-I-associated disorders: two with dermatitis and one with "smouldering" adult T-cell leukemia. Neurological and immunological function was similar in HTLV-I-seropositive and HTLV-I-seronegative subjects. HTLV-I antibodies persist over many years, and the risk for seroconversion of household contacts is low.
KW  - adult T-cell leukaemia
KW  - epidemiology
KW  - HTLV-I infections
KW  - human diseases
KW  - infections
KW  - serological surveys
KW  - Barbados
KW  - Caribbean
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Windward Islands
KW  - Lesser Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - adult T-cell leukemia
KW  - HTLV-BLV group
KW  - seroepidemiology
KW  - West Indies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine regulation of HIV replication induced by dendritic cell-CD4-positive T cell interactions.
AU  - Weissman, D.
AU  - Daucher, J.
AU  - Barker, T.
AU  - Adelsberger, J.
AU  - Baseler, M.
AU  - Fauci, A. S.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 9
SP  - 759
EP  - 767
SN  - 0889-2229
AD  - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007212.  Publication Type: Journal Article.  Language: English.  Number of References: 71 ref.
N2  - It has been established that human immunodeficiency virus (HIV) replication occurs throughout the course of disease in the lymphoid tissue. We have developed a model system to study the effect of cytokines and other agents on HIV replication using cocultures of DCs and T cells that reflect the cell-to-cell interactions that occur in the microenvironment of lymphoid tissue. Dendritic cells from peripheral blood, when pulsed with small amounts of HIV, induce infection in autologous, unstimulated CD4-positive T cells. Using this system, cytokines, anti-cytokine antibodies, and inhibitors of cellular activation were added to cultures and the effects on cellular proliferation and activation and HIV production were measured. Cytokines that increased T cell proliferation, such as IL-2 and IL-4, enhanced HIV replication, while the effect of IL-12 was more complex. HIV production was inhibited by blocking endogenously produced IL-2, as well as by adding IL-10, which blocks IL-2 secretion, antigen-presenting cell function, and T cell activation. Proinflammatory cytokines induced modest enhancement of viral replication in cocultures of HIV-pulsed DCs and CD4-positive T cells. Thus, using a model of HIV replication that more closely mimics the in vivo microenvironment of lymphoid tissue may allow a better analysis of the effect of cytokines and cytokine networks, as well as agents that modify immune activation on HIV replication.
KW  - CD4+ lymphocytes
KW  - cytokines
KW  - dendritic cells
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - interleukins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007212&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Conference summary: novel HIV therapies-from discovery to clinical proof of concept.
AU  - Miller, R. H.
AU  - Turk, S. R.
AU  - Black, R. J.
AU  - Bridges, S.
AU  - Sarver, N.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 10
SP  - 859
EP  - 865
SN  - 0889-2229
AD  - Miller, R. H.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962008088.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 32 ref.
KW  - antiviral agents
KW  - gene therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunotherapy
KW  - pathogenesis
KW  - research
KW  - therapy
KW  - vaccines
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - studies
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008088&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Models of HIV type 1 proviral gene expression in wild-type HIV and MLV/HIV transgenic mice.
AU  - Dickie, P.
AU  - Gazzinelli, R.
AU  - Chang LungJi
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 12
SP  - 1103
EP  - 1116
SN  - 0889-2229
AD  - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19962007809.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
N2  - Two proviral HIV transgenic mouse models, one bearing wild-type HIV proviral DNA and the other a modified provirus in which the viral LTRs contained the core enhancer of the Moloney murine leukemia virus (MLV), were compared. The MLV/HIV chimeric LTR, in which the MLV enhancer replaced the NF-κB-binding motifs, was transcriptionally active in human and murine cells in vitro and virus containing the chimeric LTR was replication competent in human cell cultures. Transgenic mice derived from microinjections of chimeric MLV/HIV proviral DNA transcribed HIV genes at a greater frequency and at higher levels than wild-type HIV proviral transgenic mice. MLV/HIV mice were also more apt to develop disease; wasting, periocular infections, and a degenerative myopathy characterized the most predominant phenotype. The tissue specificities of the wild-type and chimeric LTRs in transgenic mice were remarkably similar, but a significant difference was apparent in lymphoid cells. Basal level and LPS-inducible HIV gene expression occurred in peritoneal and bone marrow-derived macrophages from wild-type HIV transgenic mice. In contrast, HIV gene expression in macrophages from MLV/HIV mice was undetectable, even following LPS induction. However, cultured splenocytes from MLV/HIV mice supported HIV proviral gene transcription better than splenocytes from HIV mice, particularly after induction with LPS or anti-IgD antibody but not with concanavalin A. These data suggest that in transgenic mice, the HIV and MLV/HIV LTRs display a differential tropism for macrophages and B cells, respectively. HIV and MLV/HIV transgenic mice represent alternative models amenable to in vivo studies of HIV gene regulation in lymphoid cells, the induction of HIV-related disease and the evaluation of anti-HIV therapies.
KW  - animal models
KW  - disease course
KW  - gene expression
KW  - genetically engineered organisms
KW  - HIV-1 infections
KW  - human diseases
KW  - transgenic animals
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GMOs
KW  - human immunodeficiency virus type 1
KW  - transgenic organisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007809&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mother-to-infant transmission of HIV type 1: role of major histocompatibility antigen differences.
AU  - Mittleman, B. B.
AU  - Shearer, G. M.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1996///
VL  - 12
IS  - 15
SP  - 1397
EP  - 1400
SN  - 0889-2229
AD  - Mittleman, B. B.: Experimental Immunology Branch, National Cancer Institute/NIH, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972008909.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
KW  - antigens
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - major histocompatibility complex
KW  - maternal transmission
KW  - pregnancy
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - gestation
KW  - histocompatibility complex
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - mother to child transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008909&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Myopathy and spontaneous Pasteurella pneumotropica-induced abscess formation in an HIV-1 transgenic mouse model.
AU  - Dickie, P.
AU  - Mounts, P.
AU  - Purcell, D.
AU  - Miller, G.
AU  - Fredrickson, T.
AU  - Chang, L. J.
AU  - Martin, M. A.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 13
IS  - 2
SP  - 101
EP  - 116
AD  - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19972001944.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9007-49-2, 63231-63-0. 
N2  - In an effort to augment HIV-1 gene expression in transgenic mice, an infectious proviral DNA clone was modified by deleting the two NFκ B binding sites and some adjacent upstream LTR sequences and replacing them with the core enhancer of Moloney murine leukaemia virus (MLV). Two independent lines of MLV/HIV transgenic mice were established that expressed HIV-1-specific RNA in lymphoid tissue, striated skeletal muscle, and the eye lens. Heterozygous animals from each transgenic line spontaneously developed an inflammatory disease of the eye associated with the production of copious amounts of purulent lacrimal secretions beginning at 2 weeks of age. Periorbital abscess formation became grossly apparent by 2 months of age and Pasteurella pneumotropica was cultured from the harderian glands and conjunctival surfaces of many of the MLV/HIV animals but not their nontransgenic, cohabiting littermates. This gram-negative commensal bacterium has been previously associated with a similar disease phenotype in immunocompromised (e.g., nude mice) rodent colonies. MLV/ HIV mice developed normally until 15 weeks of age, when weight loss and wasting occurred, culminating in premature death (as earlier as 6 months of age). The cachexia was associated with an initially focal and subsequently progressive myopathy, coinciding with age-related increases of HIV gene expression in muscle.
KW  - abscesses
KW  - age differences
KW  - animal models
KW  - clones
KW  - death
KW  - DNA
KW  - enhancers
KW  - eyes
KW  - gene expression
KW  - genetically engineered organisms
KW  - Gram negative bacteria
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - leukaemia
KW  - modification
KW  - muscular diseases
KW  - phenotypes
KW  - prematurity
KW  - RNA
KW  - secretions
KW  - skeleton
KW  - transgenic animals
KW  - weight losses
KW  - Bacteria
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Pasteurella
KW  - Pasteurella pneumotropica
KW  - rodents
KW  - viruses
KW  - Bacteria
KW  - prokaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Pasteurella
KW  - abscess
KW  - bacterium
KW  - blood cancer
KW  - deoxyribonucleic acid
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GEOs
KW  - GMOs
KW  - Gram-negative bacteria
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - leucaemia
KW  - leukemia
KW  - myopathy
KW  - ribonucleic acid
KW  - transgenic mice
KW  - transgenic organisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001944&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cigarette smoking, bacterial pneumonia, and other clinical outcomes in HIV-1 infection.
AU  - Burns, D. N.
AU  - Hillman, D.
AU  - Neaton, J. D.
AU  - Sherer, R.
AU  - Mitchell, T.
AU  - Capps, L.
AU  - Vallier, W. G.
AU  - Thurnherr, M. D.
AU  - Gordin, F. M.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 13
IS  - 4
SP  - 374
EP  - 383
AD  - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19972001320.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref.
N2  - Cigarette smoking has been associated with impaired immune defenses and an increased risk of certain infectious and neoplastic diseases in HIV-1 seronegative populations. The relationship between cigarette smoking and clinical outcome was studied in a prospective cohort of 3221 HIV-1-seropositive men and women enrolled in the Terry Beirn Community Programs for Clinical Research on AIDS. Differences in clinical outcomes between never, former and current cigarette smokers were assessed using proportional hazards regression analysis. After adjustment for CD4+ cell count, prior disease progression, use of antiretroviral therapy and other covariates, there was no difference between current smokers and never smokers in the overall risk of opportunistic diseases or death. However, current smokers were more likely than never smokers to develop bacterial pneumonia, oral candidosis and AIDS dementia complex. In addition, current smokers were less likely to develop Kaposi's sarcoma and several other non-respiratory tract diseases. If confirmed by other studies, these findings have important clinical implications.
KW  - acquired immune deficiency syndrome
KW  - AIDS dementia complex
KW  - candidosis
KW  - cigarettes
KW  - clinical aspects
KW  - death
KW  - disease course
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - mouth
KW  - pneumonia
KW  - tobacco smoking
KW  - USA
KW  - Candida
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - candidiasis
KW  - clinical picture
KW  - disease progression
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001320&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Insights on the pathogenicity of human T-lymphotropic/leukemia virus types I and II.
AU  - Cereseto, A.
AU  - Mulloy, J. C.
AU  - Franchini, G.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 13
IS  - SUP 1
SP  - S69
EP  - S75
AD  - Cereseto, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972000164.  Publication Type: Journal Article.  Language: English.  Number of References: 79 ref. Registry Number: 102524-44-7, 85898-30-2. 
KW  - cell cycle
KW  - HTLV-I infections
KW  - human diseases
KW  - interleukin 2
KW  - microbiology
KW  - pathogenesis
KW  - pathogenicity
KW  - receptors
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000164&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The promiscuous IL-2/IL-15 receptor: a target for immunotherapy of HTLV-I-associated disorders.
AU  - Waldmann, T. A.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1996///
VL  - 13
IS  - SUP 1
SP  - S179
EP  - S185
AD  - Waldmann, T. A.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972000177.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 102524-44-7, 85898-30-2. 
KW  - adult T-cell leukaemia
KW  - HTLV infections
KW  - human diseases
KW  - immunotherapy
KW  - interleukin 15
KW  - interleukin 2
KW  - receptors
KW  - treatment
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adult T-cell leukemia
KW  - HTLV therapy
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000177&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats.
AU  - Remmers, E. F.
AU  - Longman, R. E.
AU  - Du Ying
AU  - O'Hare, A.
AU  - Cannon, G. W.
AU  - Griffiths, M. M.
AU  - Wilder, R. L.
JO  - Nature Genetics
JF  - Nature Genetics
Y1  - 1996///
VL  - 14
IS  - 1
SP  - 82
EP  - 85
SN  - 1061-4036
AD  - Remmers, E. F.: Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19960106488.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2  - Identification of specific genetic loci that contribute to susceptibility to rheumatoid arthritis (RA) in man has been hampered by several factors, including (1) multiple interacting genetic loci contributing to susceptibility, (2) complex interactions of environmental and genetic factors, (3) genetic heterogeneity, and (4) low penetrance. Quantitative trait loci (QTLs) were mapped that control inflammatory arthritis susceptibility and/or severity in progeny of 2 inbred rat strains with significantly different susceptibilities to collagen-induced arthritis (CIA), an animal model for RA. A major susceptibility factor, Cia1, was identified on Chr 20 in the vicinity of the rat MHC. By limiting the analysis to animals with arthritis-susceptible MHC genotypes and using genome-wide QTL analytical techniques, 4 non-MHC QTLs, Cia2, 3, 4 and 5, were found on Chr 1, 4, 7 and 10, which contributed to disease severity. In addition, a QTL on Chr 8 was suggestive of linkage.
KW  - animal models
KW  - arthritis
KW  - biotechnology
KW  - collagen
KW  - diseases
KW  - gene mapping
KW  - genes
KW  - human diseases
KW  - immunogenetics
KW  - linkage
KW  - major histocompatibility complex
KW  - quantitative trait loci
KW  - quantitative traits
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - histocompatibility complex
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960106488&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preclinical efficacy of a glucuronoxylomannan-tetanus toxoid conjugate vaccine of Cryptococcus neoformans in a murine model.
AU  - Devi, S. J. N.
JO  - Vaccine
JF  - Vaccine
Y1  - 1996///
VL  - 14
IS  - 9
SP  - 841
EP  - 844
SN  - 0264-410X
AD  - Devi, S. J. N.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961201912.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A conjugate vaccine composed of the cryptococcal capsular glucuronoxylomannan covalently coupled to tetanus toxoid (GXM-TT) was constructed and evaluated. The vaccine elicited high levels of capsular antibodies in mice by active and passive immunizations and conferred 70-80% protection against a moderate challenge with 10³C. neoformans. Monitoring of serum GXM and anti-GXM antibody levels and of incidence of cryptococcal isolation from various organs of mice indicated that presence of vaccine-induced antibodies during the first 4-6 wk of infection is critical for clearance of cryptococci from various organs, for limiting serum GXM titres from reaching immunosuppressive levels and ultimately for survival.
KW  - antibodies
KW  - conjugate vaccines
KW  - cryptococcosis
KW  - efficacy
KW  - experimental infections
KW  - human diseases
KW  - humoral immunity
KW  - immunology
KW  - infections
KW  - mannans
KW  - vaccination
KW  - vaccines
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - capsule
KW  - european blastomycosis
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201912&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of tissue diagnosis in pulmonary involvement in pediatric human immunodeficiency virus infection.
AU  - Izraeli, S.
AU  - Mueller, B. U.
AU  - Ling, A.
AU  - Temeck, B. K.
AU  - Lewis, L. L.
AU  - Chang, R.
AU  - Shad, A. T.
AU  - Pass, H. I.
AU  - Pizzo, P. A.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1996///
VL  - 15
IS  - 2
SP  - 112
EP  - 116
SN  - 0891-3668
AD  - Izraeli, S.: Pediatric Branch, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19962004413.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref.
KW  - biopsy
KW  - children
KW  - diagnosis
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lungs
KW  - respiratory diseases
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - lung diseases
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004413&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Specific and total carotenoid intakes among oral contraceptive and estrogen hormone users in the United States.
AU  - Nebeling, L. C.
AU  - Forman, M. R.
AU  - Graubard, B. I.
AU  - Snyder, R. A.
JO  - Journal of the American College of Nutrition
JF  - Journal of the American College of Nutrition
Y1  - 1996///
VL  - 15
IS  - 6
SP  - 608
EP  - 613
SN  - 0731-5724
AD  - Nebeling, L. C.: National Cancer Institute, Division of Cancer Prevention and Control, Executive Plaza North, Suite 211, 6130 Executive Blvd ., MSC 7326, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19971401781.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Human Nutrition
N2  - Carotenoid intakes were compared between hormone users and non-users in a nationally representative sample of women in the USA. Women with potentially greater risk for disease were identified. Data from the 1987 National Health Interview Survey's - Epidemiology Supplement food frequency questionnaire were linked to the United States Department of Agriculture-National Cancer Institute Carotenoid database to estimate mean total and specific carotenoid intakes. Women (n=8962) were grouped by menopausal status and classified by hormone use into premenopausal oral contraceptive users/non-users (n=5918) and postmenopausal oestrogen replacement hormone users/non-users (n=3044). Mean carotenoid intakes and standard errors were weighted using the SUDAAN software package and adjusted for potential confounding factors using multiple linear regression analysis. Compared with non-users, oral contraceptive users had lower specific carotenoid intakes. Demographic and lifestyle characteristics differed between oral contraceptive users/non-users and were examined in relation to carotenoid intakes. More oral contraceptive users than non-users were married, highly educated, drank alcoholic beverages and smoked. After adjustment for these factors in a multiple linear regression model, the associations between oral contraceptive use and carotenoid intake remained significant. Mean carotenoid intakes were not different among oestrogen hormone replacement users versus non-users. It was concluded that oral contraceptive users have lower dietary carotenoid intakes than non-users. Since oral contraceptive users smoke and drink more than non-users, and both factors are associated with lower carotenoid intakes, oral contraceptive users form a potential high risk group for disease.
KW  - alcoholic beverages
KW  - carotenoids
KW  - contraceptives
KW  - diet studies
KW  - hormone supplements
KW  - hormones
KW  - intake
KW  - menopause
KW  - oestrogens
KW  - oral contraceptives
KW  - replacement
KW  - risk
KW  - socioeconomic status
KW  - tobacco smoking
KW  - women
KW  - Usa
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - estrogens
KW  - tetraterpenoids
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401781&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cryptococcosis in human immunodeficiency virus-infected children.
AU  - Gonzalez, C. E.
AU  - Shetty, D.
AU  - Lewis, L. L.
AU  - Mueller, B. U.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1996///
VL  - 15
IS  - 9
SP  - 796
EP  - 800
SN  - 0891-3668
AD  - Gonzalez, C. E.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971200785.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - Cases of paediatric cryptococcosis were identified through a retrospective review of the hospital records of the 473 HIV-infected children prospectively monitored in the Pediatric Branch of the National Cancer Institute, Maryland, USA, during 1987-95. Four (0.85%) patients developed cryptococcosis during the study period. All patients had profound depression of the absolute CD4+ cell counts, a history of previous opportunistic infections and onset of cryptococcosis in the second decade of life. Cryptococcosis developed as a disseminated infection or a localized process of the lungs. Intermittent fever was the most common presenting manifestation. Serum cryptococcal antigen was positive in all patients and gradually declined after the institution of antifungal therapy. All patients were treated with amphotericin B with or without flucytosine as initial therapy. Suppressive therapy consisted of fluconazole with or without flucytosine. There were no deaths due to Cryptococcus neoformans. It is concluded that cryptococcosis is an infrequent yet treatable opportunistic infection of advanced paediatric AIDS that may present with subtle manifestations and warrants careful consideration in the evaluation of febrile HIV-infected children.
KW  - acquired immune deficiency syndrome
KW  - amphotericin B
KW  - children
KW  - cryptococcosis
KW  - fluconazole
KW  - flucytosine
KW  - generalized infections
KW  - HIV infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - opportunistic infections
KW  - predisposition
KW  - Maryland
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - 5-fluorocytosine
KW  - AIDS
KW  - european blastomycosis
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200785&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sociodemographic, hygienic and nutritional correlates of Helicobacter pylori infection of young Bangladeshi children.
AU  - Clemens, J.
AU  - Albert, M. J.
AU  - Rao, M.
AU  - Huda, S.
AU  - Qadri, F.
AU  - Loon, F. P. L. van
AU  - Pradhan, B.
AU  - Naficy, A.
AU  - Banik, A.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1996///
VL  - 15
IS  - 12
SP  - 1113
EP  - 1118
SN  - 0891-3668
AD  - Clemens, J.: Epidemiology Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B03, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972003260.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 308067-58-5.  Subject Subsets: Tropical Diseases; Rural Development; Human Nutrition
N2  - A random population-based survey of 257 rural Bangladeshi children aged 2-5 years and 312 children aged 6-9 years was carried out. Seropositivity for Helicobacter pylori, as manifested by the presence of serum IgG anti-H. pylori antibodies, was correlated with nutritional status of the sampled children and with sociodemographic features and access to clean water and latrine facilities among families of the children. Among children aged 2-5 years, the 123 (48%) who were infected with H. pylori were similar to the 134 non-infected children with respect to socioeconomic level, family access to tube well water and family ownership of a latrine. However, families of infected children had more persons per sleeping room in the home (3.8 vs. 3.2, P &lt;0.05) and were more likely to be Hindu (20% vs. 10%, P &lt;0.05). Infected children did not differ significantly from non-infected children in Z scores for weight-for-age (-2.66 vs. -2.78), weight-for-height (-1.17 vs. -1.28) or height-for-age (-3.58 vs. -3.56). Analysis of survey children aged 6-9 years also revealed similar nutritional indexes among infected vs. non-infected children. It was concluded that household crowding and behaviours that differ between Hindus and Muslims, but not lack of access to clean water and latrines, may enhance the transmission of H. pylori to rural Bangladeshi children. Although confirming the high frequency of infections in young Bangladeshi children, the findings do not support the notion that H. pylori is responsible for the high prevalence of malnutrition in this setting.
KW  - bacterial diseases
KW  - children
KW  - disease transmission
KW  - epidemiology
KW  - families
KW  - households
KW  - human diseases
KW  - hygiene
KW  - IgG
KW  - infections
KW  - malnutrition
KW  - nutritional state
KW  - risk factors
KW  - rural areas
KW  - rural development
KW  - socioeconomic status
KW  - socioeconomics
KW  - Asia
KW  - Bangladesh
KW  - Helicobacter pylori
KW  - man
KW  - Helicobacter
KW  - Helicobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - nutritional status
KW  - socioeconomic aspects
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Income and Poverty (EE950) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003260&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Statistical evidence for shared transient causes of anatomically distinct birth defects.
AU  - Weinberg, C. R.
AU  - Skjærven, R.
AU  - Wilcox, A. J.
JO  - Statistics in Medicine
JF  - Statistics in Medicine
Y1  - 1996///
VL  - 15
IS  - 19
SP  - 2029
EP  - 2036
SN  - 0277-6715
AD  - Weinberg, C. R.: MD A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19962008646.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref.
N2  - Certain pairs of anatomically distinct birth defects co-occur in the same baby more often than predicted under independence. Such an excess might reflect either the fact that some subpopulations of parents have inherently increased risk for both, or that certain pregnancies are at increased risk for both, even within the same couple, perhaps, due to transient exposures specific to the pregnancy. The authors focus on the latter possibility in the context of a large birth registry and two relatively common types of defects, by testing the null hypothesis that within sibships the two defects occur independently. Focusing on sibships where both defects occurred, they propose a test based on the total number of 'co-incidences', sibships where both occurred in the same baby. Such a test can be carried out either with or without allowance for possible dependence of risk on birth order. Applying this to club foot and sex organ defects among sibships from the Medical Birth Registry of Norway, strong evidence for excess within-family co-incidence was found, suggesting that there are shared, time-varying (hence perhaps modifiable) causal components in their aetiology.
KW  - congenital abnormalities
KW  - disease statistics
KW  - human diseases
KW  - incidence
KW  - risk
KW  - statistical analysis
KW  - statistics
KW  - Norway
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - EFTA
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - birth defects
KW  - congenital malformations
KW  - statistical methods
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008646&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - cis-Acting sequences located downstream of the human immunodeficiency virus type 1 promoter affect its chromatin structure and transcriptional activity.
AU  - El-Kharroubi, A.
AU  - Martin, M. A.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1996///
VL  - 16
IS  - 6
SP  - 2958
EP  - 2966
SN  - 0270-7306
AD  - El-Kharroubi, A.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006826.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
KW  - chromatin
KW  - human diseases
KW  - promoters
KW  - regulatory sequences
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA transcription
KW  - human immunodeficiency virus type 1
KW  - promoter region
KW  - promoter sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006826&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA.
AU  - Clemens, K. E.
AU  - Piras, G.
AU  - Radonovich, M. F.
AU  - Kyeong Sook Choi
AU  - Duvall, J. F.
AU  - DeJong, J.
AU  - Roeder, R.
AU  - Brady, J. N.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1996///
VL  - 16
IS  - 9
SP  - 4656
EP  - 4664
SN  - 0270-7306
AD  - Clemens, K. E.: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892-5055, USA.
N1  - Accession Number: 19962008541.  Publication Type: Journal Article.  Language: English.  Number of References: 112 ref.
N2  - The authors report a physical and functional interaction between Tax and the transcription factor, TFIIA. First, Tax was found to interact with the 35-kDa (α) subunit of TFIIA in the yeast two-hybrid interaction system. Two previously characterized mutants with point mutations in Tax, M32 (Y196A, K197S) and M41 (H287A, P288S), which were shown to be defective in Tax-activated transcription were unable to interact with TFIIA in this assay. Secondly, a glutathione-S-transferase (GST) affinity-binding assay showed that the interaction of holo-TFIIA with GST-Tax was 20-fold higher than that observed with either the GST-Tax M32 activation mutant or the GST control. Thirdly, a coimmunoprecipitation assay showed that in HTLV-1-infected human T lymphocytes, Tax and TFIIA were associated. Finally, TFIIA facilitates Tax transactivation in vitro and in vivo. In vitro transcription studies showed reduced levels of Tax-activated transcription in cell extracts depleted of TFIIA. In addition, transfection of human T lymphocytes with TFIIA expression vectors enhanced Tax-activated transcription of an HTLV-1 long terminal repeat-chloramphenicol acetyltransferase reporter construct. The study suggests that the interaction of Tax with the transcription factor TFIIA may play a role in Tax-mediated transcriptional activation.
KW  - HTLV-I infections
KW  - human diseases
KW  - Tax protein
KW  - transactivation
KW  - transcription factors
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008541&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protective immunity against HIV infection: has nature done the experiment for us?
AU  - Shearer, G. M.
AU  - Clerici, M.
JO  - Immunology Today
JF  - Immunology Today
Y1  - 1996///
VL  - 17
IS  - 1
SP  - 21
EP  - 21
SN  - 0167-4919
AD  - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002671.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref.
KW  - acquired immune deficiency syndrome
KW  - blood products
KW  - health care workers
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunity
KW  - immunology
KW  - needle sharing
KW  - risk factors
KW  - sexual behaviour
KW  - T lymphocytes
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002671&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Schistosomiasis as a predisposing factor to veno-occlusive disease of the liver following allogeneic bone marrow transplantation.
AU  - Mahmoud, H. K.
JO  - Bone Marrow Transplantation
JF  - Bone Marrow Transplantation
Y1  - 1996///
VL  - 17
IS  - 3
SP  - 401
EP  - 403
SN  - 0268-3369
AD  - Mahmoud, H. K.: BMT Unit, National Cancer Institute, Cairo University, Egypt.
N1  - Accession Number: 19960805566.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Among 89 allogeneic bone marrow transplant recipients in Egypt, veno-occlusive disease of the liver (VOD) was diagnosed in 10 patients (11.2%). All cases (n=5) with schistosomal hepatic periportal fibrosis detected by pre-transplant ultrasonography developed severe fatal VOD in spite of normal initial liver functions and absence of portal hypertension. 3 had a history of infection with Schistosoma mansoni and 2 with S. haematobium. The incidence of VOD among patients without previous schistosomal contact was 5.95% (5 of 84). The relative risk to develop VOD was calculated to be 16.8-fold higher in patients with previous schistosomiasis. Schistosomal hepatic periportal fibrosis may thus be added to the known risk factors predisposing to the development of VOD in allogeneic transplant recipients.
KW  - bone marrow transplant
KW  - helminths
KW  - human diseases
KW  - liver
KW  - liver diseases
KW  - parasites
KW  - pathogenicity
KW  - schistosomiasis
KW  - Africa
KW  - Egypt
KW  - man
KW  - Schistosoma
KW  - Schistosoma haematobium
KW  - Schistosoma mansoni
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Schistosoma
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - bilharzia
KW  - bilharziasis
KW  - Misr
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805566&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evolving concepts of prevention and treatment of invasive fungal infections in pediatric bone marrow transplant recipients.
AU  - Chanock, S. J.
AU  - Walsh, T. J.
JO  - Bone Marrow Transplantation
JF  - Bone Marrow Transplantation
Y1  - 1996///
VL  - 18
IS  - Suppl. 3
SP  - S15
EP  - S20
SN  - 0268-3369
AD  - Chanock, S. J.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971201896.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 53 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 84625-61-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - The current approach towards therapeutic options available for the prevention and treatment of fungal infections in children undergoing marrow transplantation is reviewed. Treatment with amphotericin B, imidazoles, fluconazole, itraconazole and flucytosine is discussed.
KW  - amphotericin B
KW  - antifungal agents
KW  - bone marrow transplant
KW  - children
KW  - drug therapy
KW  - fluconazole
KW  - flucytosine
KW  - fungicides
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - itraconazole
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - prevention
KW  - prophylaxis
KW  - reviews
KW  - therapy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 5-fluorocytosine
KW  - chemotherapy
KW  - fungistats
KW  - Marrow transplantation in children - current results and controversies
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201896&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Correlates and predictors of weight loss in young adults: the CARDIA study.
AU  - Bild, D. E.
AU  - Sholinsky, P.
AU  - Smith, D. E.
AU  - Lewis, C. E.
AU  - Hardin, J. M.
AU  - Burke, G. L.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1996///
VL  - 20
IS  - 1
SP  - 47
EP  - 55
SN  - 0307-0565
AD  - Bild, D. E.: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Federal Building, Room 300, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961401235.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Human Nutrition
N2  - A study was conducted to examine associations of sociodemographic characteristics, behaviours, attitudes and medical factors with weight loss in a population-based biracial cohort of young adults. 4278 black and white men and women aged 18-30 years were studied in 1985-1986. Weight, height, education, income, subscapular skinfold thickness, waist and hip circumferences, medical history, smoking, physical activity, dietary energy, fat and alcohol intake, physical fitness measured by treadmill testing, self-reported dieting, history of weight loss and regain, perception of body size and belief in health consequences of overweight were recorded. Results showed that weight loss, defined as reduction of 5% or more of baseline weight, occurred in 8.9% of the cohort, ranging from 4.9% among white men who were not overweight at baseline to 21.5% among white women who were overweight. Weight loss was more common in women than men and in overweight white women than overweight black women. Although findings differed among the 4 race-sex groups, weight loss was generally associated with greater baseline fatness, lower baseline physical fitness level, self-perception of being overweight, dieting and previous weight loss and regain. Greater baseline fatness, a perception of being overweight and dieting were also associated with weight gain. Among the overweight, low baseline fitness and an increase in physical activity were the factors most consistently associated with weight loss. Weight loss in young adults varies by race, sex and body weight and is associated with a variety of behaviours and attitudes, some of which are also associated with weight gain and, thus, may be associated with weight fluctuation.
KW  - adults
KW  - diet
KW  - epidemiology
KW  - exercise
KW  - health
KW  - obesity
KW  - overweight
KW  - weight reduction
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961401235&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recall of body weight and body size estimation in women enrolled in the breast cancer detection and demonstration project (BCDDP).
AU  - Muñoz, K. A.
AU  - Ballard-Barbash, R.
AU  - Graubard, B.
AU  - Swanson, C. A.
AU  - Schairer, C.
AU  - Kahle, L. L.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1996///
VL  - 20
IS  - 9
SP  - 854
EP  - 859
SN  - 0307-0565
AD  - Muñoz, K. A.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19961409732.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Human Nutrition
N2  - The relationship between body mass index (BMI) and pictorial representations of body size were examined in 5807 women (33-77 years old) enrolled in the National Cancer Institute's and American Cancer Society's Breast Cancer Detection and Demonstration Project (BCDDP). Body weight and height were estimated in 1973. In 1977, a subset of the cohort recalled their usual height and weight at 10-year intervals starting at age 20. In 1987, subjects reported their usual and current weight and selected 1 of 9 pictorials best representing their body size at 15, 25, 40, 50 and +60 years old. For the cohort and among Caucasian women, Pearson correlations between recalled BMI (kg/m²) and pictorials for each decade ranged from 0.62-0.67 and was 0.80 for current BMI and current pictorial. The range of correlations between pictorials and recalled BMI for other race/ethnic groups were 0.72-0.87 (Black), 0.53-0.75 (Hispanic) and 0.28-0.87 (Asian). Among a subset of women with data on estimated BMI, recalled BMI and pictorials at specific ages, correlation between pictorials and estimated BMI was 0.75, compared to the correlation between recalled BMI and estimated BMI which was 0.89. Correlations between recalled BMI and estimated BMI were increased compared with the correlation between pictorials and estimated BMI. Therefore, estimates of body size by pictorials alone may not be appropriate for epidemiological investigations. Alternate uses of pictorials may include assessment of body weight in low literate populations or in instances where body weight is not or has not been estimated.
KW  - age
KW  - assessment
KW  - body measurements
KW  - body weight
KW  - estimation
KW  - ethnic groups
KW  - mammary gland neoplasms
KW  - self perception
KW  - size
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - mammary tumour
KW  - self concept
KW  - United States of America
KW  - Techniques and Methodology (ZZ900) 
KW  - Human Nutrition (General) (VV100) 
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961409732&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dual energy X-ray absorptiometry: inter-machine variability.
AU  - Tataranni, P. A.
AU  - Pettitt, D. J.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1996///
VL  - 20
IS  - 11
SP  - 1048
EP  - 1050
SN  - 0307-0565
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19961411039.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Subject Subsets: Human Nutrition
N2  - Dual-energy X-ray absorptiometry (DEXA) is rapidly becoming the method of choice for body composition measurements. Inter-machine variability was tested because large differences in body composition measurements between different DEXA machines have been reported. A comparison of total scans using 2 DEXA machines from the same manufacturer (DPX-L; Lunar Co, Madison, WI) on subjects (5 men, 5 women; 31-58 years old) was carried out. Significant differences were observed between the 2 machines for all mean values of body composition variables as a result of a systematic underestimation of bone mineral and overestimation of fat tissue by one machine compared with the other. However, the magnitude of the observed differences was small (namely bone mineral 68±57 g; percent body fat -1.7±1%). It was concluded that differences do exist in the performances of 2 DEXA machines from the same manufacturer. Although the differences reported in this study are small, emphasis should be given in pre-testing machines when multiple apparatuses are used in a study. Also, because the observed error was systematic, randomized designs are necessary when more than one DEXA machine is used in a longitudinal/intervention study. Better yet, manufacturers of DEXA machine should standardize their equipments to ensure the best consistency between machines.
KW  - analytical methods
KW  - body composition
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - Techniques and Methodology (ZZ900) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961411039&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Estimating the attributable risk of residential radon among nonsmoking women: initial results and methodologic challenges.
AU  - Alavanja, M. C. R.
AU  - Brownson, R. C.
AU  - Benichou, J.
AU  - Boice, J.
A2  - Hopke, P. K.
JO  - Environment International
JF  - Environment International
Y1  - 1996///
VL  - 22
IS  - Suppl. 1
SP  - S1005
EP  - S1013
SN  - 0160-4120
AD  - Alavanja, M. C. R.: Department of Health & Human Services, National Institutes of Health, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982002656.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 10043-92-2. 
N2  - A population-based, case-control study of incident lung cancer among women in Missouri (USA) who were lifetime nonsmokers and long-term exsmokers was conducted in 1986-92. The study included 538 lung cancer cases and 1183 population-based, age matched controls. Information on lung cancer risk factors was obtained by interviewing cases, next-of-kin of cases and controls. Year-long radon measurements were also sought in every dwelling occupied for the previous 5-30 years. The mean radon level found in homes was 1.6 pCi/litre. This level of radon exposure is somewhat higher than that observed in the USA as a whole (mean 1.25 pCi/litre). A small nonsignificant risk was found for study subjects exposed to a median domestic radon concentration of 4 pCi/litre (25 year time-weight average). Since only a small fraction of the population is exposed at this level, it is estimated that the population attributable risk (PAR) for domestic radon is between 1 and 4% in Missouri. The growing body of residential studies has not clearly shown an elevation in lung cancer risk due to low-level, long-term radon exposure. It may be difficult to demonstrate a statistically significant increase in risk due in part to the inherent methodological difficulties associated with assessing the potential carcinogenic effect of low-level radon exposure, errors in reconstructing past radon exposures and population mobility which tends to homogenize exposures. A complementary method of radon exposure measurement, now being used in a second epidemiological evaluation of lung cancer in Missouri, which uses heirloom glass to assess actual historic cumulative dose, is discussed, and may help strengthen future studies.
KW  - epidemiology
KW  - exposure
KW  - human diseases
KW  - lung cancer
KW  - neoplasms
KW  - radon
KW  - risk
KW  - risk factors
KW  - women
KW  - Missouri
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002656&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus.
AU  - Spooner, K. M.
AU  - Lane, H. C.
AU  - Masur, H.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1996///
VL  - 23
IS  - 1
SP  - 15
EP  - 27
SN  - 1058-4838
AD  - Spooner, K. M.: Critical Care Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001961.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
N2  - The results of clinical trials, meta-analyses and observational studies of antiretroviral therapy administered to HIV-1-infected patients are presented. The tables are based upon published articles and abstracts, and both the results of each study and the reviewers' interpretation are presented.
KW  - antiviral agents
KW  - clinical trials
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - therapy
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001961&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A cluster of cases of chronic fatigue and chronic fatigue syndrome: clinical and immunologic studies.
AU  - Levine, P. H.
AU  - Dale, J. K.
AU  - Benson-Grigg, E.
AU  - Fritz, S.
AU  - Grufferman, S.
AU  - Straus, S. E.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1996///
VL  - 23
IS  - 2
SP  - 408
EP  - 409
SN  - 1058-4838
AD  - Levine, P. H.: Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962008848.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref.
N2  - In 1993 a cluster of chronic fatigue syndrome (CFS) cases was investigated in a women's residential facility in the USA, which was associated with an outbreak of influenza-like illness in February 1990. Between 1990 and 1993 36 women had lived in the facility, 16 of whom reported fatigue that lasted ≤1 month during the 3-year study interval. 2 of the residents who entered the facility before 1990 already had fatigue, 5 residents stated that the onset of fatigue corresponded to the outbreak of the influenza-like illness, and 9 women described no temporal relationship between their fatigue and the influenza outbreak. In 2 of these 9 women the fatigue resolved after several weeks, but in the other 7 women it persisted. In 1993, 14 of 18 women residing in the facility were enrolled in this study, including 8 healthy women and 6 with fatigue (3 with fatigue dating to the influenza outbreak and 3 with fatigue that arose at other times). Standardized questionnaires and laboratory tests revealed that only 2 fatigued women met Centers for Disease Control and Prevention (CDC) criteria for CFS, including 1 with symptoms dating to the influenza outbreak. The results of routine blood studies and serologies for antibodies to Epstein-Barr virus and human herpesvirus type 6 were comparable among fatigued and healthy residents. It is concluded from this analysis that: the reported clustering of the cases was exaggerated; no clinical, psychological, or immunological feature that was assessed distinguished residents whose fatigue arose in association with the influenza-like illness from those in whom the fatigue was more clearly sporadic or from the healthy controls; most subjects did not meet the CDC criteria for CFS and those who did meet the criteria could not be distinguished from those who did not.
KW  - chronic fatigue syndrome
KW  - clinical aspects
KW  - fatigue
KW  - human diseases
KW  - immunology
KW  - influenza
KW  - outbreaks
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - clinical picture
KW  - flu
KW  - tiredness
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008848&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for fungemia in children infected with human immunodeficiency virus: a case-control study.
AU  - Gonzalez, C. E.
AU  - Venzon, D.
AU  - Lee, S.
AU  - Mueller, B. U.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1996///
VL  - 23
IS  - 3
SP  - 515
EP  - 521
SN  - 1058-4838
AD  - Gonzalez, C. E.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961202436.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A matched case-control study was performed to define the risk factors related to the occurrence of fungaemia in HIV-positive children. During 1987-93, 22 (6.3%) of 347 HIV-positive children at the Pediatric Branch of the National Cancer Institute, Maryland, USA, developed fungaemia. Causative organisms were Candida albicans (14 episodes), C. parapsilosis (4), C. tropicalis (2), C. krusei (1), Torulopsis glabrata (4), Rhodotorula rubra (3) and Bipolaris spicifera [Cochliobolus spicifer] (1). Each of these 22 cases was matched by age and gender with 3 controls. Multiple logistic regression indicated that the best predictor of fungaemia in this population was the presence of a central venous catheter placed for &gt;90 d (P&lt;0.00001), followed by a group of risk factors composed of 10 independent variables adjusted for a CD4 cell count of &lt;100/µl (P&lt;0.045). Those variables included treatment with &gt;3 antibiotics, treatment with &gt;3 parenteral antibiotics, &gt;30 d of antibiotic treatment, bacterial infections, &gt;30 d in the hospital, hypoalbuminaemia, C3 classification of HIV infection and malnourishment. It is concluded that prolonged placement of central venous catheters is the most important risk factor for fungaemia in HIV-infected children and that the risk of fungaemia is further influenced by antibacterial therapy, catheter manipulation and host response.
KW  - acquired immune deficiency syndrome
KW  - blood
KW  - candidosis
KW  - catheters
KW  - children
KW  - fungaemia
KW  - hiv infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - opportunistic infections
KW  - predisposition
KW  - risk factors
KW  - Maryland
KW  - USA
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - Cochliobolus spicifer
KW  - man
KW  - Pleosporaceae
KW  - Rhodotorula mucilaginosa
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Cochliobolus
KW  - Pleosporaceae
KW  - Pleosporales
KW  - Dothideomycetes
KW  - Pezizomycotina
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Rhodotorula
KW  - Sporidiobolales
KW  - Microbotryomycetes
KW  - Pucciniomycotina
KW  - Basidiomycota
KW  - Torulopsis
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - Candida krusei
KW  - candidiasis
KW  - fungemia
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - Rhodotorula rubra
KW  - Torulopsis glabrata
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Asymptomatic solitary pulmonary nodules due to Cryptococcus neoformans in patients infected with human immunodeficiency virus.
AU  - Miller, K. D.
AU  - Mican, J. A. M.
AU  - Davey, R. T.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1996///
VL  - 23
IS  - 4
SP  - 810
EP  - 812
SN  - 1058-4838
AD  - Miller, K. D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971202492.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Cases are reported in 3 HIV-positive men (aged 38, 44 and 42 years) from Maryland, USA, who developed solitary pulmonary nodules caused by Cryptococcus neoformans which were identified on routine surveillance chest roentgenograms.
KW  - asymptomatic infections
KW  - case reports
KW  - cryptococcosis
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - men
KW  - opportunistic infections
KW  - predisposition
KW  - Maryland
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - european blastomycosis
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971202492&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diethylcarbamazine-induced reversal of early lymphatic dysfunction in a patient with bancroftian filariasis: assessment with use of lymphoscintigraphy.
AU  - Moore, T. A.
AU  - Reynolds, J. C.
AU  - Kenney, R. T.
AU  - Johnston, W.
AU  - Nutman, T. B.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1996///
VL  - 23
IS  - 5
SP  - 1007
EP  - 1011
SN  - 1058-4838
AD  - Moore, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970801110.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 90-89-1, 1642-54-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - The clinical presentation of expatriates exposed to infective larvae of Wuchereria bancrofti is distinct from the chronic pathological condition seen among the native population and is similar to the findings in experimentally infected individuals who show early development of signs of lymphatic obstruction. The case of a 25-year-old Peace Corps volunteer working in Gabon is presented, who developed acute lymphatic dysfunction with leg swelling within 3 months of arriving in an area that was endemic for filariasis. The diagnosis was established clinically and by using an ELISA which detected antibodies that reacted specifically to the recombinant W. bancrofti protein Wb 1.2. Lymphatic flow was markedly abnormal when assessed with use of 99mTc-lymphoscintigraphy. Treatment with a 21-day course of diethylcarbamazine (6 mg/kg/day) followed by prophylaxis with 300 mg of diethylcarbamazine weekly reversed both the physical and lymphoscintigraphic abnormalities and prevented further recurrence.
KW  - anthelmintics
KW  - bancroftian filariasis
KW  - case reports
KW  - clinical aspects
KW  - diagnosis
KW  - diagnostic techniques
KW  - diethylcarbamazine
KW  - drug therapy
KW  - ELISA
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - lymph flow
KW  - lymphatic diseases
KW  - lymphatic filariasis
KW  - lymphatic system
KW  - nematode infections
KW  - parasites
KW  - pathology
KW  - prophylaxis
KW  - Africa
KW  - Gabon
KW  - man
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - chemotherapy
KW  - clinical picture
KW  - enzyme linked immunosorbent assay
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mycobacterium chelonae infection mimicking cutaneous vasculitis: case report.
AU  - Sran, P. K.
AU  - Kansupada, K.
AU  - Whitcup, S. M.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1996///
VL  - 23
IS  - 5
SP  - 1189
EP  - 1190
SN  - 1058-4838
AD  - Sran, P. K.: National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972000875.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Public Health
N2  - This paper reports the case of a 60-year-old woman from Hawaii with subcutaneous nodules due to Mycobacterium chelonae infection that were difficult to differentiate from vasculitis, panniculitis or abscess.
KW  - aetiology
KW  - bacterial diseases
KW  - case reports
KW  - epidemiology
KW  - human diseases
KW  - infection
KW  - infections
KW  - women
KW  - Hawaii
KW  - North America
KW  - USA
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium chelonae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Polynesia
KW  - Oceania
KW  - Pacific Islands
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - causal agents
KW  - etiology
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000875&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Fatal Trichosporon pullulans breakthrough fungemia in cancer patients: report of three patients who failed on prophylaxis with itraconazole.
AU  - Kunová, A.
AU  - Godal, J.
AU  - Sufliarsky, J.
AU  - Špánik, S.
AU  - Kollár, T.
AU  - Krčméry, V., Jr.
T2  - Infection
JO  - Infection
JF  - Infection
Y1  - 1996///
VL  - 24
IS  - 3
SP  - 273
EP  - 274
SN  - 0300-8126
AD  - Kunová, A.: National Cancer Institute, Trnava, Slovakia.
N1  - Accession Number: 19961201553.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Registry Number: 1397-89-3, 84625-61-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - Cases are reported in a 65-yr-old woman and 63- and 55-yr-old men from Slovakia who were receiving itraconazole prophylaxis (200 or 100 mg/d) during chemotherapy through a central venous catheter for neoplastic diseases. All 3 patients were neutropenic and developed fever. Blood cultures grew T. pullulans in all 3 cases. Amphotericin B was started in all patients but 2 died of the infection after 6 and 1 d of therapy. One patient improved after amphotericin B therapy but he died 17 d later after progression of his underlying disease.
KW  - amphotericin B
KW  - antifungal agents
KW  - blood
KW  - case reports
KW  - catheters
KW  - drug therapy
KW  - fungaemia
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - itraconazole
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - prophylaxis
KW  - Slovakia
KW  - man
KW  - Trichosporon
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - Trichosporon
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - cancers
KW  - chemotherapy
KW  - fungemia
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Trichosporon pullulans
KW  - trichosporonosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The potential of dietary modification to prevent cancer.
AU  - Greenwald, P.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1996///
VL  - 25
IS  - 1
SP  - 41
EP  - 43
SN  - 0091-7435
AD  - Greenwald, P.: Division of Cancer Prevention and Control, National Cancer Institute, Building 31, Room 10A52, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19961408417.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 10 ref. Subject Subsets: Human Nutrition
N2  - An overview is presented.
KW  - diet
KW  - modification
KW  - neoplasms
KW  - prevention
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Health Foundation 25th anniversary symposium
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408417&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Can school health education programs make a difference?
AU  - Stone, E. J.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1996///
VL  - 25
IS  - 1
SP  - 54
EP  - 55
SN  - 0091-7435
AD  - Stone, E. J.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 2 Rockledge Center, Room 8134, 6701 Rockledge Drive, Bethesda, Maryland 20892-7936, USA.
N1  - Accession Number: 19961408420.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 12 ref. Subject Subsets: Human Nutrition
N2  - A brief overview is presented focusing on the Child and Adolescent Trial for Cardiovascular Health. This 8-year multicentre (96 schools in California, Louisiana, Minnesota and Texas, USA) randomized trial (1987-1994) investigated whether behaviourally orientated cardiovascular school- and family-based health programmes could produce positive changes in health habits and favourably affect the cardiovascular risk profiles of elementary school children. Interventions included classroom curricular and school environmental modifications related to food consumption, physical activity and tobacco use. Family- and home-based programmes complemented the school-based activities.
KW  - behaviour
KW  - cardiovascular diseases
KW  - children
KW  - families
KW  - food consumption
KW  - health education
KW  - homes
KW  - physical activity
KW  - reviews
KW  - risk
KW  - school children
KW  - tobacco smoking
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - American Health Foundation 25th anniversary symposium
KW  - behavior
KW  - school kids
KW  - schoolchildren
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary retinoic acid inhibits mouse skin carcinogenesis irrespective of age at initiation.
AU  - Luca, L. M. de
AU  - Tarone, R.
AU  - Huynh Minh
AU  - Jones, C. S.
AU  - Chen LiChuan
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1996///
VL  - 25
IS  - 3
SP  - 249
EP  - 257
SN  - 0163-5581
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001413028.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - In the two-stage protocol of skin carcinogenesis, the carcinogen 7,12-dimethylbenz[aanthracene (DMBA) is applied to the skin of mice at around 7 weeks of age. We previously performed DMBA initiation at three weeks of age to study the effect of pharmacological (30 µg/g diet) dietary retinoic acid (RA) on skin carcinogenesis. In this study we asked whether dietary pharmacological RA is equally effective against skin carcinogenesis when mice are initiated with (DMBA) at 7 weeks of age and then subjected to weekly applications of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) or mezerein (MEZ) for 20 weeks. Similar to the 3-week initiation protocol, high dietary RA inhibited papilloma incidence and yield in MEZ- but not in TPA-promoted female SENCAR mice. In addition, carcinoma incidence and yield were decreased by high dietary RA in TPA- as well as MEZ-treated mice. These data demonstrate that the high dietary RA diet is as effective in inhibiting papilloma and carcinoma formation when the DMBA is applied at 7 weeks of age as at 3 weeks.
KW  - age
KW  - carcinogenesis
KW  - carcinogens
KW  - carcinoma
KW  - diets
KW  - neoplasms
KW  - papilloma
KW  - promoters
KW  - retinoic acid
KW  - skin
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - dermis
KW  - papillomas
KW  - promoter region
KW  - promoter sequences
KW  - tretinoin
KW  - vitamin A acid
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413028&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Influence of dietary protein, fat, and fiber on growth, blood chemistry, and tumor incidences in Fischer 344 rats.
AU  - Rao, G. N.
AU  - Edmondson, J.
AU  - Hildebrandt, P. K.
AU  - Bruner, R. H.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1996///
VL  - 25
IS  - 3
SP  - 269
EP  - 279
SN  - 0163-5581
AD  - Rao, G. N.: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 20001413170.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Composition of diets may influence growth, diseases, tumour rates, and responses to chemical treatment. For two years, Fischer 344 rats were fed the NIH-07 open-formula nonpurified diet (23% protein, 5% fat, and 3.5% fibre) and nonpurified experimental diets (NTP-90, NTP-91, and NTP-92) containing lower protein and higher fat and fibre (14.6-15.3% protein, 7.2-8.5% fat, and 9.4-14% fibre) than the NIH-07 diet. Rats were evaluated for growth patterns, survival, haematology, serum chemistry, nephropathy, and tumour incidences. Growth patterns were similar in rats fed the experimental diets and in those fed the NIH-07 diet. However, in rats fed the experimental diets, the adult body weights were significantly (6-9%) lower and the survival at 110 weeks of age was significantly higher (15-20%) than in rats fed the NIH-07 diet. Lower protein content of experimental diets decreased the severity of nephropathy. Higher fat content of experimental diets appears to have decreased the incidence or delayed the development of leukaemia and associated mortality in males. Higher fibre content of experimental diets appears to have delayed the development of mammary tumours and associated mortality in females. Higher fat and/or fibre of the experimental diets decreased the incidence of pheochromocytomas in males. The lower protein and higher fat and fibre contents of the experimental diets decreased the spontaneous tumour burden in two-year studies. These studies indicate that diets for rats in long-term studies could be modified to decrease the severity of nephropathy and to decrease/delay the development of spontaneous tumours.
KW  - blood chemistry
KW  - chemical treatment
KW  - composition
KW  - diets
KW  - evaluation
KW  - fat
KW  - fibre
KW  - haematology
KW  - intake
KW  - kidney diseases
KW  - leukaemia
KW  - mortality
KW  - neoplasms
KW  - protein
KW  - protein content
KW  - protein intake
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood cancer
KW  - cancers
KW  - death rate
KW  - fiber
KW  - hematology
KW  - kidney disorders
KW  - leucaemia
KW  - leukemia
KW  - nephropathy
KW  - renal diseases
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reproducibility of a self-administered diet History Questionnaire administered three times over three different seasons.
AU  - Hartman, A. M.
AU  - Block, G.
AU  - Chan, W.
AU  - Williams, J.
AU  - McAdams, M.
AU  - Banks, W. L., Jr.
AU  - Robbins, A.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1996///
VL  - 25
IS  - 3
SP  - 305
EP  - 315
SN  - 0163-5581
AD  - Hartman, A. M.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 20001413173.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Human Nutrition
N2  - The reproducibility of the widely used Health Habits and History Questionnaire (HHHQ) for estimating "usual past-year" nutrient intake was examined. The HHHQ was self-administered on three occasions during three different seasons; 68 women (average age 43 years) provided usable data for all three questionnaires in the appropriate seasons. Intraclass correlations (ICC) among the three administrations ranged from 0.56 (carotene) to 0.82 (fat as percentage of energy), with a median of 0.72. Thus, reliability was moderate to good, and season of administration/ordinality generally had little impact on ranking of individuals. The point estimates of intake of energy and a number of nutrients were higher in the first administration (winter). Except for dietary fibre and possibly carotene, most differences disappeared when adjusted for energy using a nutrient density approach, as well as using repeated-measures regression models. The higher intake in the first administration may be due more to either learning or fatigue effects rather than an effect of seasonal food availability on perceptions of usual intake. These data should be used in conjunction with validity data in the future to help evaluate the gain in precision of group means (and changes in these means) and improved estimates of odds ratios and correlations between nutrients and factors such as serum values, if a questionnaire is administered more than once.
KW  - analytical methods
KW  - carotenes
KW  - diets
KW  - fibre
KW  - food intake
KW  - health
KW  - intake
KW  - models
KW  - nutrients
KW  - questionnaires
KW  - ratios
KW  - seasonal variation
KW  - seasons
KW  - surveys
KW  - winter
KW  - analytical techniques
KW  - fiber
KW  - seasonal changes
KW  - seasonal fluctuations
KW  - Techniques and Methodology (ZZ900) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preventing AIDS among drug users: evaluating efficacy.
AU  - Singer, M.
AU  - Needle, R.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1996///
VL  - 26
IS  - 3
SP  - 521
EP  - 523
AD  - Singer, M.: Hispanic Health Council, National Institute on Drug Abuse, NIH, Bethesda MD, USA.
N1  - Accession Number: 19972006198.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref.
N2  - Based on the lessons, both positive and negative, learned during the first wave of AIDS prevention projects targeted to drug users, the authors say that we are now in a position to move to a second wave of even more effective prevention models. Given the high rates of HIV and other life-threatening infections among drug users, especially in some regions of the country and elsewhere in the world, there is a critical need to build on the kind of projects reported in this special issue to make the "Stop AIDS" slogan of the AIDS movement a reality.
KW  - acquired immune deficiency syndrome
KW  - disease prevention
KW  - drug abuse
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - injecting drug users
KW  - prevention
KW  - transmission
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - drug use
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - i.v. drug abusers
KW  - i.v. drug users
KW  - intravenous drug users
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.
AU  - Turpin, J. A.
AU  - Schaeffer, C. A.
AU  - Ming Bu
AU  - Graham, L.
AU  - Buckheit, R. W. Jr.
AU  - Clanton, D.
AU  - Rice, W. G.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1996///
VL  - 29
IS  - 2/3
SP  - 269
EP  - 277
SN  - 0166-3542
AD  - Turpin, J. A.: Laboratory of Antiviral Drug Mechanisms, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Building 431T-B. P.O. Box B. Frederick, MD 21702, USA.
N1  - Accession Number: 19962008295.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref.
KW  - antiviral agents
KW  - HIV-1 infections
KW  - human diseases
KW  - proteinase inhibitors
KW  - replication
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - human secretory leukocyte proteinase inhibitor
KW  - protease inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immune-based therapies for treatment of HIV infection.
AU  - Piscitelli, S. C.
AU  - Minor, J. R.
AU  - Saville, M. W.
AU  - Davey, R. T., Jr.
JO  - Annals of Pharmacotherapy
JF  - Annals of Pharmacotherapy
Y1  - 1996///
VL  - 30
IS  - 1
SP  - 62
EP  - 76
SN  - 1042-9611
AD  - Piscitelli, S. C.: Department of Pharmacy, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007945.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Number of References: 145 ref. Registry Number: 9008-11-1, 308079-78-9. 
KW  - cytokines
KW  - gene therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunotherapy
KW  - interferon
KW  - interleukins
KW  - reviews
KW  - tumour necrosis factor
KW  - vaccines
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heat loss during cold exposure in adult and aged C57BL/6J mice.
AU  - Shefer, V. I.
AU  - Talan, M. I.
AU  - Engel, B. T.
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1996///
VL  - 31
IS  - 5
SP  - 597
EP  - 604
SN  - 0531-5565
AD  - Shefer, V. I.: Gerontology Research Center, Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
N1  - Accession Number: 19971401195.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Human Nutrition
N2  - Metabolic heat production (MHP), colonic temperature (Tco), and nonevaporative (dry) heat loss were measured in adult and aged C57BL/6J male mice during cold exposure. Dry heat loss was assessed as a differential temperature (Td) between incoming and outgoing air through the chamber for indirect calorimetry. The average Td during cold exposure normalized to surface area for adult mice was significantly higher than that for the aged mice (0.0618±0.0003°C/cm² and 0.0553±0.0005°C/cm², respectively). Linear regression analysis showed that, at the same Tco, aged mice showed lower values of Td normalized to surface area, indicating that at the same body temperature they were losing less heat than ADULT animals. It was concluded that age-related decline in cold tolerance in mice is not due to a lack of ability to reduce heat loss during cold exposure. On the contrary, AGED animals had lower heat loss in comparison with ADULT. We suggest that augmentation of heat conservation mechanisms is an adaptive response to diminishing cold-induced heat production.
KW  - age
KW  - aging
KW  - body temperature
KW  - cold stress
KW  - energy metabolism
KW  - heat loss
KW  - heat production
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - calorigenesis
KW  - thermogenesis
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Losses of arachidonic acid in rat liver after alcohol inhalation.
AU  - Salem, N., Jr.
AU  - Reyzer, M.
AU  - Karanian, J.
JO  - Lipids
JF  - Lipids
Y1  - 1996///
VL  - 31
IS  - SUPPL
SP  - S153
EP  - S156
SN  - 0024-4201
AD  - Salem, N., Jr.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, 12501 Washington Ave., Rockville, MD 20852, USA.
N1  - Accession Number: 19961404425.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 12 ref. Registry Number: 506-32-1, 64-17-5.  Subject Subsets: Human Nutrition
N2  - Rats were exposed to alcohol by inhalation and were fed a diet that simulated the poor diet of some alcoholics. It is hypothesized that some of the pathophysiological effects of alcohol are related to its effects on essential fatty acid metabolism and composition of vital organs. A diet that contains no 20 and 22-carbon essential fatty acids and has low levels of 18-carbon essential fatty acids was used as a dietary challenge. Addition of a second metabolic challenge, i.e., alcohol, led to loss of tissue polyunsaturates, particularly liver arachidonate. A method of cycling alcohol inhalation for 12 h/day was also presented, which was also shown to lower liver arachidonic acid content.
KW  - arachidonic acid
KW  - diet
KW  - essential fatty acids
KW  - ethanol
KW  - inhalation
KW  - liver
KW  - losses
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 2nd congress of the International Society for the Study of Fatty Acids and Lipids
KW  - eicosatetraenoic acid
KW  - ethyl alcohol
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians.
AU  - Tataranni, P. A.
AU  - Baier, L. J.
AU  - Paolisso, G.
AU  - Howard, B. V.
AU  - Ravussin, E.
JO  - Lipids
JF  - Lipids
Y1  - 1996///
VL  - 31
IS  - SUPPL
SP  - S267
EP  - S270
SN  - 0024-4201
AD  - Tataranni, P. A.: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Diabetes and Nutrition Section, 4212 N. 16th Str., Room 541-A, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19961404436.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 31 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - The role of lipids in the pathogenesis of noninsulin-dependent diabetes mellitus (NIDDM) was examined in Pima Indians. High plasma levels of nonesterified fatty acid (NEFA) predicted development of NIDDM, but this effect cannot entirely be explained by the glucose-fatty acid cycle. Dyslipaemia, although often associated with diabetes, did not predict NIDDM and might be associated with, or the consequence of, insulin resistance. In some individuals, a single amino acid substitution in the intestinal fatty acid binding protein could result in increased rates of intestinal absorption of dietary NEFA and thereby contribute to increased lipid oxidation rates and insulin resistance.
KW  - American Indians
KW  - diabetes
KW  - ethnic groups
KW  - fatty acids
KW  - insulin
KW  - lipid metabolism
KW  - lipids
KW  - pathogenesis
KW  - resistance
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - 2nd congress of the International Society for the Study of Fatty Acids and Lipids
KW  - fat metabolism
KW  - lipins
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The structure-activity relationship of lipoxygenase products of long-chain polyunsaturated fatty acids: effects on human platelet aggregation.
AU  - Karanian, J. W.
AU  - Kim HeeYong
AU  - Salem, N., Jr.
JO  - Lipids
JF  - Lipids
Y1  - 1996///
VL  - 31
IS  - SUPPL
SP  - S305
EP  - S308
SN  - 0024-4201
AD  - Karanian, J. W.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcoholsm and Alcohol Abuse, National Institutes of Health, Room 2, 12501 Washington St., Rockville, MD 20852, USA.
N1  - Accession Number: 19961404444.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 26 ref. Registry Number: 506-32-1, 25167-62-8, 9029-60-1.  Subject Subsets: Human Nutrition
N2  - The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was examined to delineate potencies and structure-activity function. The 22-carbon n-3 fatty acids were more potent inhibitors than the n-6 lipoxygenase derivatives. Submicromolar levels of docosapentaenoic and especially docosahexaenoic hydroperoxy and hydroxy derivatives specifically antagonized the platelet aggregating effect of arachidonic acid (AA) but not that of ADP or collagen. Chain length (22-C &gt; 20-C), double-bond position (n-3 &gt; n-6), and double-bond number (6 &gt; 5 &gt; 4) influenced the degree of inhibition of AA-induced aggregation of platelets. Moreover, significant differences in potency were associated with specific structural aspects of lipoxygenase derivatives of docosahexaenoic acid as follows: functional group (OOH &gt; OH) and positional isomer (14-OOH, 14-OH, 20-OOH &gt; 11-OOH, 17-OOH &gt; 10-OOH &gt; 11-OH, 8-OOH, 7-OOH &gt; 4-OOH).
KW  - aggregation
KW  - arachidonic acid
KW  - blood coagulation
KW  - docosahexaenoic acid
KW  - eicosanoids
KW  - in vitro
KW  - lipoxygenase
KW  - long chain fatty acids
KW  - platelets
KW  - polyenoic fatty acids
KW  - products
KW  - structure
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 2nd congress of the International Society for the Study of Fatty Acids and Lipids
KW  - blood platelets
KW  - clotting system
KW  - eicosatetraenoic acid
KW  - polyunsaturated fatty acids
KW  - thrombocytes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
AU  - Foli, A.
AU  - Sogocio, K. M.
AU  - Anderson, B.
AU  - Kavlick, M.
AU  - Saville, M. W.
AU  - Wainberg, M. A.
AU  - Gu ZhengXian
AU  - Cherrington, J. M.
AU  - Mitsuya, H.
AU  - Yarchoan, R.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1996///
VL  - 32
IS  - 2
SP  - 91
EP  - 98
SN  - 0166-3542
AD  - Foli, A.: Medicine Branch, National Cancer Institute, Bethesda, MD 20892-1906, USA.
N1  - Accession Number: 19962009010.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
KW  - antiviral agents
KW  - drug resistance
KW  - enzyme inhibitors
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - mutations
KW  - reverse transcriptase inhibitors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Psychopharmacology in HIV-positive patients: research perspectives.
AU  - Vitiello, B.
AU  - Stover, E. S.
JO  - Psychopharmacology Bulletin
JF  - Psychopharmacology Bulletin
Y1  - 1996///
VL  - 32
IS  - 3
SP  - 293
EP  - 297
AD  - Vitiello, B.: National Institute of Mental Health, Office on AIDS, Rockville, MD 20857, USA.
N1  - Accession Number: 19972002306.  Publication Type: Journal Article; Annual report; Journal article.  Language: English.  Number of References: 17 ref.
N2  - Psychotropic medications play an important role in the treatment of HIV-positive subjects suffering from neuropsychiatric disorders or other AIDS-related symptomatology. The quality of life of these patients can be significantly improved by the appropriate use of these agents. Various aspects of psychopharmacology that are relevant to HIV-positive patients include assessment of efficacy, tolerability, drug-interactions and effects on cognition. These topics need further investigation and require focused research efforts. This report highlights current research needs and presents specific recommendations that emerged at a recent meeting on psychopharmacology for HIV-positive patients organized by the National Institute of Mental Health (NIMH), Maryland, USA.Editorial Comment:This paper reviews the state-of-the-art in psychopharmacology research in HIV infection and makes a number of suggestions for increasing our research data base in this important area of treatment research.
KW  - acquired immune deficiency syndrome
KW  - drug therapy
KW  - guidelines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - patients
KW  - psychosocial aspects
KW  - research
KW  - sociology
KW  - treatment
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - neuropsychiatry
KW  - recommendations
KW  - social aspects
KW  - studies
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toward a high-resolution Plasmodium falciparum linkage map: polymorphic markers from hundreds of simple sequence repeats.
AU  - Su XinZhuan
AU  - Wellems, T. E.
JO  - Genomics (San Diego)
JF  - Genomics (San Diego)
Y1  - 1996///
VL  - 33
IS  - 3
SP  - 430
EP  - 444
SN  - 0888-7543
AD  - Su XinZhuan: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA.
N1  - Accession Number: 19960804366.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Simple sequence length polymorphisms (SSLPs) were investigated for use as markers for genetic studies of Plasmodium falciparum. Of 507 simple sequence repeats identified from P. falciparum sequences in GenBank and a genomic DNA library, 224 were tested for polymorphisms using polymerase chain reaction assays. This yielded a set of 188 that showed SSLPs among different parasite lines, of which 116 were assigned to previously mapped chromosome linkage groups. Features of the SSLPs are consistent with the view that malaria parasites evolved from algal-like ancestors.
KW  - chromosome maps
KW  - chromosomes
KW  - DNA libraries
KW  - evolution
KW  - genetic markers
KW  - genetic polymorphism
KW  - genetics
KW  - genome analysis
KW  - linkage
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804366&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Granulocyte-macrophage colony-stimulating factor and interferon-γ prevent dexamethasone-induced immunosuppression of antifungal monocyte activity against Aspergillus fumigatus hyphae.
AU  - Roilides, E.
AU  - Blake, C.
AU  - Holmes, A.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1996///
VL  - 34
IS  - 1
SP  - 63
EP  - 69
SN  - 0268-1218
AD  - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200831.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The effect of dexamethasone (DEX) on superoxide anion (O2-) release and damage caused by elutriated human monocytes (EHM) on unopsonized hyphae of A. fumigatus were investigated. In addition, the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-γ (IFN-γ) on these functions of DEX-treated EHM were also studied. Treatment of EHM with concn of DEX in the range 5-500 nM (1.4-140 ng/ml) for 48 h suppressed O2- release in response to phorbol myristate acetate in a dose-dependent fashion. Similarly, DEX significantly suppressed hyphal damage caused by EHM as measured by colorimetric MTT assay. Both GM-CSF (5 mg/ml) and IFN-γ (1.2 ng/ml) added at day 0 to the EHM together with DEX (500 nM) significantly enhanced O2- release and percentage hyphal damage, preventing the DEX-induced suppression of EHM function. GM-CSF and IFN-γ prevented the deleterious effects of DEX on antifungal activity of EHM against Aspergillus, suggesting a potential therapeutic role in patients at risk for or suffering from invasive aspergillosis.
KW  - colony stimulating factor
KW  - corticoids
KW  - cytokines
KW  - immune response
KW  - immunology
KW  - immunosuppression
KW  - immunotherapy
KW  - monocytes
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - corticosteroids
KW  - fungus
KW  - Hyphomycetes
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200831&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of hepatic and renal P4502E1 of neonatal rats exposed translactationally to ethanol.
AU  - Chhabra, S. K.
AU  - Perella, C.
AU  - Anderson, L. M.
JO  - Food and Chemical Toxicology
JF  - Food and Chemical Toxicology
Y1  - 1996///
VL  - 34
IS  - 5
SP  - 469
EP  - 476
SN  - 0278-6915
AD  - Chhabra, S. K.: Perinatal Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, SAIC-Frederick, Frederick, MD 21702, USA.
N1  - Accession Number: 19970400393.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9035-51-2, 64-17-5.  Subject Subsets: Dairy Science; Human Nutrition
N2  - The effect of maternal ethanol intake during lactation on neonatal cytochrome P4502E1 was investigated in Sprague-Dawley rats. Mother rats were exposed to 15% (v/v) ethanol in drinking water from day 1 of lactation to 4, 7 or 14 days postpartum. Hepatic and renal N-nitrosodimethylamine (NDMA) demethylase activities were increased (P&lt;0.01), an activity of cytochrome P4502E1, in lactating rats given ethanol in drinking water. NDMA demethylase activity also increased (P&lt;0.01) in the livers of 7- and 14-day old female and male rat pups and in the kidneys of 7- and 14-day female and 14-day male rat pups exposed to ethanol through the transmammary route. Cytochrome P4502E1 protein content, assayed by immunoblotting, increased in the maternal liver and kidney of all groups consuming ethanol. Cytochrome P4502E1 protein content increased in the livers of 7- and 14-day old male and female and in the kidneys of 14-day female rat pups exposed translactationally to ethanol. No effect of ethanol on enzyme activity or protein content of cytochrome P4502E1 was observed in the liver or kidney of 4-day-old rat pups. Results demonstrate the translactational effect of ethanol on neonatal cytochrome P4502E1, which is involved in the metabolism of many low molecular weight xenobiotics, and indicate the possibility of alterations occurring in the kinetics of neonatal drug and xenobiotic metabolism and also in processes connected with perinatal carcinogenesis.
KW  - activity
KW  - cytochrome p-450
KW  - enzymes
KW  - ethanol
KW  - intake
KW  - kidneys
KW  - lactation
KW  - liver
KW  - progeny
KW  - proteins
KW  - rat feeding
KW  - rat milk
KW  - young animals
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ethyl alcohol
KW  - rat lactation
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Milk and Dairy Produce (QQ010) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Improved plaque assays for Rickettsia prowazekii in Vero76 cells.
AU  - Policastro, P. F.
AU  - Peacock, M. G.
AU  - Hackstadt, T.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1996///
VL  - 34
IS  - 8
SP  - 1944
EP  - 1948
SN  - 0095-1137
AD  - Policastro, P. F.: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19970500180.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Typhus group rickettsiae, including R. prowazekii and R. typhi, produce visible plaques on primary chick embryo fibroblasts and low-passage mouse embryo fibroblasts but do not form reproducible plaques on continuous cell culture lines. The authors tested medium overlay modifications for plaque formation of typhus group rickettsiae on the continuous fibroblast cell line Vero76. A procedure involving primary overlay with medium at pH 6.8, which was followed 2-3 days later with secondary overlay at neutral pH containing 1 µg of emetine per ml and 20 µg of NaF per ml, resulted in visible plaques at 7-10 days postinfection. A single-step procedure involving overlay with medium containing 50 ng of dextran sulfate per ml also resulted in plaque formation within 8 days postinfection. These assays represent reproducible and inexpensive methods for evaluating the infectious titres of typhus group rickettsiae, cloning single plaque isolates, and testing the susceptibilities of rickettsiae to antibiotics.
KW  - assays
KW  - cell culture
KW  - cell lines
KW  - culture techniques
KW  - fibroblasts
KW  - Rickettsia canadensis
KW  - Rickettsia prowazekii
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - plaque assays
KW  - plaque formation
KW  - Rickettsia canada
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500180&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis.
AU  - Schwan, T. G.
AU  - Schrumpf, M. E.
AU  - Hinnebusch, B. J.
AU  - Anderson, D. E., Jr.
AU  - Konkel, M. E.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1996///
VL  - 34
IS  - 10
SP  - 2483
EP  - 2492
SN  - 0095-1137
AD  - Schwan, T. G.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19970501357.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Public Health
N2  - Serological confirmation of tick-borne relapsing fever is based on either an immunofluorescence assay or an ELISA using whole cells or sonicated Borrelia hermsii as the antigen. However, antigenic variability of this bacterium's outer surface proteins and antigens shared with the Lyme disease spirochaete (B. burgdorferi), may cause both false-negative and false-positive results when testing sera of patients suspected to have either relapsing fever or Lyme disease. To develop a specific serological test for relapsing fever, the authors created a genomic DNA library of B. hermsii, screened transformed Escherichia coli cells for immunoreactivity with high-titred (≥1:2048) human anti-B. hermsii antiserum, and selected an immunoreactive clone (pSPR75) expressing a 39-kDa protein. DNA sequencing, subcloning and serum adsorption experiments identified the immunoreactive protein as a homologue of GlpQ, a glycerophosphodiester phosphodiesterase identified previously in E. coli, Haemophilus influenzae and Bacillus subtilis. Serum samples from humans and mice infected with Borrelia hermsii or other species of relapsing fever spirochaetes contained antibodies recognizing GlpQ, whereas serum samples from Lyme disease and syphilis patients were nonreactive.
KW  - antigens
KW  - clones
KW  - diagnosis
KW  - diagnostic techniques
KW  - DNA
KW  - enzymes
KW  - human diseases
KW  - immunodiagnosis
KW  - Lyme disease
KW  - proteins
KW  - relapsing fever
KW  - tickborne relapsing fever
KW  - Borrelia
KW  - Borrelia burgdorferi
KW  - Borrelia hermsii
KW  - Escherichia coli
KW  - man
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Borrelia
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - bacterium
KW  - Borreia hermsii
KW  - deoxyribonucleic acid
KW  - E. coli
KW  - immunogens
KW  - lyme borreliosis
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of Chiron HIV-1/HIV-2 recombinant immunoblot assay.
AU  - Kline, R. L.
AU  - McNairn, D.
AU  - Holodniy, M.
AU  - Mole, L.
AU  - Margolis, D.
AU  - Blattner, W.
AU  - Quinn, T. C.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1996///
VL  - 34
IS  - 11
SP  - 2650
EP  - 2653
SN  - 0095-1137
AD  - Kline, R. L.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19982002240.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref.
N2  - In a study to determine the reliability, sensitivity, and specificity of the Chiron RIBA HIV-1/HIV-2 Strip ImmunobVV200lot Assay (RIBA HIV-1/2 SIA) for confirmation of human immunodeficiency virus type 1 (HIV-1) and HIV-2 antibodies, 1,263 serum samples from various populations in the United States, Caribbean, Africa, India, and Thailand were evaluated by RIBA HIV-1/2 SIA, and the results were compared with those obtained by an HIV-1 Western blot (immunoblot) assay. All sera were tested by HIV enzyme immunoassay, RIBA HIV-1/2 SIA, and Western blotting. Samples with discrepant results were further tested by an HIV-1 and/or HIV-2 immunofluorescent-antibody assay and HIV-1 p24 antigen assay. The RIBA HIV-1/2 SIA detected all 17 HIV-1 and HIV-2 dually reactive serum samples, all 215 HIV-2-positive serum samples, and 480 of 481 HIV-1-positive serum samples for a sensitivity of 99.8%. Of 548 negative samples, 523 were RIBA HIV-1/2 SIA negative, for a specificity of 95.4%, with 22 (4%) samples interpreted as indeterminate and 3 (0.6%) interpreted as falsely positive. Western blotting detected 391 of 548 negative samples (specificity, 71.4%), with 152 (27.7%) samples interpreted as indeterminate and 5 (0.9%) interpreted as falsely positive. In conclusion, the RIBA HIV-1/2 SIA had a sensitivity comparable to that of Western blotting and could discriminate HIV-1 from HIV-2 in one blot, providing a cost advantage. Because of its high degree of specificity, the RIBA HIV-1/2 SIA further reduced the number of indeterminate results found by Western blotting, providing a more accurate means of assessing seronegative individuals.
KW  - evaluation
KW  - recombinant immunoblot assay
KW  - RIBA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002240&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diverse patterns of recognition of hepatitis C virus core and nonstructural antigens by antibodies present in Egyptian cancer patients and blood donors.
AU  - Attia, M. A. M.
AU  - Zekri, A. R. N.
AU  - Goudsmit, J.
AU  - Boom, R.
AU  - Khaled, H. M.
AU  - Mansour, M. T.
AU  - Wolf, F. de
AU  - Alam El-Din, H. M.
AU  - Sol, C. J. A.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1996///
VL  - 34
IS  - 11
SP  - 2665
EP  - 2669
SN  - 0095-1137
AD  - Attia, M. A. M.: Virology and Immunology, National Cancer Institute, University of Cairo, Cairo, Egypt.
N1  - Accession Number: 19972000505.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Tropical Diseases
N2  - Serum samples from 429 cancer patients, 82 unpaid blood donors, and 74 paid blood donors were tested for hepatitis C virus (HCV) markers using 2 commercially available enzyme immunoassays (EIAs). 229/429 (53.4%) cancer patients were positive by the 2 EIAs. 34/156 (21.8%) of the blood donors were positive by the EIAs, with a higher prevalence among paid blood donors (20/74; 27%) compared with that among the unpaid blood donors (14/82; 17%). EIA-positive sera were tested for confirmation of the results in an immunoblot assay (LiaTek) in which reactivities to 4 synthetic peptides representing the HCV core protein and 2 synthetic peptides representing nonstructural proteins 4 and 5 were measured. Of 243 first and/or second EIA-positive samples from cancer patients, 188 (77.2%) were confirmed to be positive in the synthetic peptide immunoblot. 33/35 (94.3%) blood donor samples were confirmed to be positive. A great diversity in reactivity patterns was seen. However, all sera from the group of paid blood donors were exclusively reactive to core peptides 1 and 2. A subset of LiaTek assay-positive samples were tested by the four-antigen RIBA-2 assay. The sera from the paid blood donors were all nonreactive. A subset of the LiaTek-positive sera was analysed for the presence of the HCV genome by reverse transcriptase-PCR. 11 of the 20 serum samples with reactivity to LiaTek core peptides 1 and 2 only were HCV reverse transcriptase-PCR positive, as were the majority of the sera with other reactivity patterns by the LiaTek assay. The results confirm the very high prevalence of HCV infection in Egypt, and also indicate that there is circulating in Egypt, particularly in the group of blood donors paid for their donation, an HCV variant which elicits an immune response that is not detected by the RIBA-2 assay.
KW  - antibodies
KW  - antigens
KW  - blood donors
KW  - detection
KW  - diagnosis
KW  - disease markers
KW  - disease prevalence
KW  - diversity
KW  - enzyme immunoassay
KW  - epidemiology
KW  - hepatitis C
KW  - human diseases
KW  - neoplasms
KW  - patients
KW  - seroprevalence
KW  - Asia
KW  - Egypt
KW  - hepatitis c virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - antigenicity
KW  - cancers
KW  - immunogens
KW  - Misr
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000505&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Long PCR and its application to hepatitis viruses: amplification of hepatitis A, hepatitis B, and hepatitis C virus genomes.
AU  - Tellier, R.
AU  - Bukh, J.
AU  - Emerson, S. U.
AU  - Miller, R. H.
AU  - Purcell, R. H.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1996///
VL  - 34
IS  - 12
SP  - 3085
EP  - 3091
SN  - 0095-1137
AD  - Tellier, R.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19972001142.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
N2  - In this study virtually the entire genomes of hepatitis A virus, hepatitis B virus, and hepatitis C virus were amplified by using the recently described technique of long PCR. In order to do this, it was first demonstrated, using the λ phage, that long PCR can be made highly sensitive and that the sensitivity can be further enhanced by nested long PCR. Using tobacco mosaic virus as a model, it was also shown that a reverse transcriptase reaction can be linked to a long PCR, enabling the nearly full-length amplification of the genomes of RNA viruses. These techniques were then applied to serial dilutions of titrated stocks of well-characterized strains of hepatitis A, B, and C viruses. The nearly full-length sequence of each of these viruses was amplified from a small number of viral genomes, demonstrating the sensitivity of the process.
KW  - amplification
KW  - genes
KW  - genomes
KW  - human diseases
KW  - molecular biology
KW  - polymerase chain reaction
KW  - viral diseases
KW  - viral hepatitis
KW  - hepatitis A virus
KW  - hepatitis B virus
KW  - hepatitis C virus
KW  - man
KW  - Hepatovirus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - Hepacivirus
KW  - Flaviviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - PCR
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001142&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10.
AU  - Mock, B. A.
AU  - Liu LiMin
AU  - Paslier, D. le
AU  - Huang Shi
JO  - Genomics (San Diego)
JF  - Genomics (San Diego)
Y1  - 1996///
VL  - 37
IS  - 1
SP  - 24
EP  - 28
SN  - 0888-7543
AD  - Mock, B. A.: National Cancer Institute, National Institutes of Health, Building 37, Room 2B08, 37 Convent Drive, MSC4255, Bethesda, Maryland 20892-4255, USA.
N1  - Accession Number: 19970100564.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology
N2  - Blimp1 restriction fragment length polymorphisms (RFLP) between BALB/cAnPt mice and Mus spretus were identified using a human BLIMP1 probe. A haplotype analysis of the RFLP in (BALB/cAnPt ×M. spretus) × BALB/cAnPt mice showed that Blimp1 was located on chromosome 10 approximately 14 cM distal to Myb.
KW  - B lymphocytes
KW  - biotechnology
KW  - gene mapping
KW  - linkage
KW  - maturation
KW  - transcription
KW  - transcription factors
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - B cells
KW  - B lymphocyte maturation promoting transcription factor
KW  - DNA transcription
KW  - maturation promoting
KW  - synteny
KW  - tumour suppressors
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - ApoA-II kinetics in humans using endogenous labeling with stable isotopes: slower turnover of apoA-II compared with the exogenous radiotracer method.
AU  - Ikewaki, K.
AU  - Zech, L. A.
AU  - Brewer, B., Jr.
AU  - Rader, D. J.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1996///
VL  - 37
IS  - 2
SP  - 399
EP  - 407
SN  - 0022-2275
AD  - Ikewaki, K.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961403257.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - ApoA-II is a major apolipoprotein constituent of HDL and may play an important role in lipoprotein metabolism and predisposition to atherosclerosis. Previous radiotracer kinetic studies have suggested that the metabolism of apoA-II in man may be different than the metabolism of apoA-I, the major HDL apolipoprotein. In the present study, an endogenous labelling technique using stable isotopically labelled amino acids was used to study apoA-II metabolism and compared the results to those obtained by a simultaneous exogenous radiotracer labelling method. 7 subjects with HDL cholesterol levels ranging from 9 to 93 mg/100 ml and apoA-II levels from 13 to 60 mg/100 ml were investigated in this study. [13C6]phenylalanine and 131I-labelled apoA-II were simultaneously administered as a primed-constant infusion and a bolus injection, respectively. In the endogenous labelling study, plateau tracer/tracee ratios of VLDL apoB-100 were used as estimates for the precursor pool tracer-tracee ratios for apoA-II synthesis. Residence times of apoA-II using these 2 independent methods were found to be highly correlated (r = 0.973, P&lt;0.0002). These results indicate that the endogenous labelling of apoA-II using stable isotopically labelled amino acids is a reasonable alternative to the conventional exogenous radiotracer labelling method for the investigation of apoA-II turnover. However, under the conditions of this experimental design and modelling strategy, the apoA-II residence times as determined by endogenous labelling were significantly longer (mean 5.33 days) than by exogenous radiotracer (mean 4.65 days). This suggests that apoA-II turnover may be even slower than believed based on radiotracer studies, and further supports the concept that HDL containing apoA-II are metabolized differently than HDL without apoA-II.
KW  - apolipoproteins
KW  - atherosclerosis
KW  - isotopes
KW  - kinetics
KW  - tracer techniques
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - Physiology of Human Nutrition (VV120) 
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12.
AU  - Zha HongBin
AU  - Remmers, E. F.
AU  - Szpirer, C.
AU  - Szpirer, J.
AU  - Zhang HeYing
AU  - Kozak, C. A.
AU  - Wilder, R. L.
JO  - Genomics (San Diego)
JF  - Genomics (San Diego)
Y1  - 1996///
VL  - 37
IS  - 3
SP  - 386
EP  - 389
SN  - 0888-7543
AD  - Zha HongBin: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19970100575.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology
N2  - A rat genomic cosmid library was screened with the mouse epimorphin cDNA probe and a single cosmid clone containing the rat epimorphin gene (Epim) was isolated. Nine contiguous exons were identified in rat Epim. The deduced amino acid sequence of rat Epim shared 96 and 86% identity with mouse and human epimorphins respectively. Using somatic cell hybridization, rat Epim was assigned to chromosome 12 and the gene was regionally localized to 12q16 by fluorescence in situ hybridization. The location of mouse Epim was determined by linkage analysis in 2 crosses: (NFS/N or C58/J ×Mus spretus) ×M. musculus musculus; (NFS/N ×Mus spretus) ×Mus spretus or C58/J. Epim was localized to chromosome 5, closely linked to Gus and Gnb2. The rat genomic DNA sequences have been submitted to GenBank/EMBL with accession numbers U35039-U35047.
KW  - biotechnology
KW  - DNA hybridization
KW  - gene mapping
KW  - linkage
KW  - maps
KW  - nucleotide sequences
KW  - somatic hybridization
KW  - man
KW  - mice
KW  - rats
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - DNA sequences
KW  - epimorphin
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Laboratory Animal Science (LL040) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Homozygosity for two point mutations in the lipoprotein lipase (LPL) gene in a patient with familial LPL deficiency: LPL(Asp9 -&gt; Asn, Tyr262 -&gt; His).
AU  - Rouis, M.
AU  - Lohse, P.
AU  - Dugi, K. A.
AU  - Lohse, P.
AU  - Beg, O. U.
AU  - Ronan, R.
AU  - Talley, G. D.
AU  - Brunzell, J. D.
AU  - Santamarina-Fojo, S.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1996///
VL  - 37
IS  - 3
SP  - 651
EP  - 661
SN  - 0022-2275
AD  - Rouis, M.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961404164.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 9004-02-8.  Subject Subsets: Human Nutrition
KW  - deficiency
KW  - glycosaminoglycans
KW  - homozygosity
KW  - hypertriglyceridaemia
KW  - lipoprotein lipase
KW  - mutations
KW  - pancreatitis
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - diacylglycerol lipase
KW  - hypertriglyceridemia
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404164&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Synthesis and assembly of chimeric human immunodeficiency virus gag pseudovirions.
AU  - Tobin, G. J.
AU  - Nagashima, K.
AU  - Gonda, M. A.
JO  - Intervirology
JF  - Intervirology
Y1  - 1996///
VL  - 39
IS  - 1/2
SP  - 40
EP  - 48
SN  - 0300-5526
AD  - Tobin, G. J.: Laboratory of Cell and Molecular Structure, SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Md., USA.
N1  - Accession Number: 19972007872.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref.
N2  - Expression of the HIV Gag precursor in insect cells by recombinant baculoviruses results in the assembly and budding of noninfectious pseudovirions that resemble immature virus. Three strategies for packaging additional viral epitopes into pseudovirions were examined: coinfection of insect cells with individual baculoviruses encoding separate Gag and Env structural genes, inframe Gag-Env fusion proteins, and Gag-frameshift-Env fusion proteins. Electron microscopy and Western blot analysis indicated that neither the coinfection nor the inframe fusion strategies reliably produced large quantities of structurally stable chimeric pseudovirions. The frameshift fusion method utilized the retroviral Gag-Pol ribosomal frameshift mechanism for the coexpression of Gag and Gag-frameshift-Env fusion proteins. Large quantities of pseudovirions containing both the Gag and Env epitopes were produced in insect cells. Mice inoculated with the Gag-frameshift-Env pseudovirions developed cytotoxic lymphocyte responses to both HIV Gag and Env epitopes. Vaccine and immunotherapeutic applications of chimeric pseudovirions are discussed.
KW  - acquired immune deficiency syndrome
KW  - cytotoxicity
KW  - epitopes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphocyte transformation
KW  - lymphocytes
KW  - mixed infections
KW  - precursors
KW  - responses
KW  - ribosomes
KW  - vaccines
KW  - western blotting
KW  - Baculoviridae
KW  - man
KW  - mice
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - AIDS
KW  - antigenic determinants
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - multiple infections
KW  - recombinant viruses
KW  - strategies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007872&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of cytokines on antiviral pharmacokinetics: an alternative approach to assessment of drug interactions using bioequivalence guidelines.
AU  - Piscitelli, S. C.
AU  - Amantea, M. A.
AU  - Vogel, S.
AU  - Bechtel, C.
AU  - Metcalf, J. A.
AU  - Kovacs, J. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1996///
VL  - 40
IS  - 1
SP  - 161
EP  - 165
SN  - 0066-4804
AD  - Piscitelli, S. C.: Department of Pharmacy, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19962004735.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 69655-05-6, 30516-87-1. 
KW  - analogues
KW  - antiviral agents
KW  - cytokines
KW  - didanosine
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - immunomodulators
KW  - nucleoside analogues
KW  - nucleosides
KW  - pharmacokinetics
KW  - zidovudine
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - analogs
KW  - AZT
KW  - dideoxyinosine
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004735&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Activation of raf-1, MEK, and MAP kinase in prolactin responsive mammary cells.
AU  - Das, R.
AU  - Vonderhaar, B. K.
JO  - Breast Cancer Research and Treatment
JF  - Breast Cancer Research and Treatment
Y1  - 1996///
VL  - 40
IS  - 2
SP  - 141
EP  - 149
SN  - 0167-6806
AD  - Das, R.: Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892-1402, USA.
N1  - Accession Number: 19960404078.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 9002-62-4, 60-18-4.  Subject Subsets: Dairy Science
N2  - It was demonstrated that 2 prolactin (PRL)-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells respond to treatment with up to 250 ng/ml PRL for up to 15 min by rapid and transient activation of a series of kinases. Raf-1 was activated within 2-5 min of PRL treatment. This was followed rapidly by activation of MEK (mitogen activated protein, MAP kinase kinase) and MAP kinase activity in these cells. Increased MAP kinase activity was accompanied by tyrosine phosphorylation of both the 42- and 44-kDa isoforms. The tyrosine kinase inhibitors genestein and tyrphostin blocked the increase in MAP kinase activity as well as PRL-induced growth of the T47D cells. It was concluded that the PRL receptor, after binding to PRL in mammary cells, activated the raf-MEK-MAP kinase pathway for signal transduction leading to mitogenesis.
KW  - activity
KW  - cell lines
KW  - enzymes
KW  - epithelium
KW  - hormone receptors
KW  - kinases
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - phosphorylation
KW  - prolactin
KW  - tyrosine
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - lactogenic hormone
KW  - mammary tumour
KW  - mammotropin
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960404078&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Randomized, controlled phase I/II trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type 1-infected patients.
AU  - Davey, R. T., Jr.
AU  - Chaitt, D. G.
AU  - Reed, G. F.
AU  - Freimuth, W. W.
AU  - Herpin, B. R.
AU  - Metcalf, J. A.
AU  - Eastman, P. S.
AU  - Falloon, J.
AU  - Kovacs, J. A.
AU  - Polis, M. A.
AU  - Walker, R. E.
AU  - Masur, H.
AU  - Boyle, J.
AU  - Coleman, S.
AU  - Cox, S. R.
AU  - Wathen, L.
AU  - Daenzer, C. L.
AU  - Lane, H. C.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1996///
VL  - 40
IS  - 7
SP  - 1657
EP  - 1664
SN  - 0066-4804
AD  - Davey, R. T., Jr.: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006874.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 30516-87-1, 136817-59-9, 69655-05-6. 
KW  - adverse effects
KW  - analogues
KW  - antiviral agents
KW  - clinical trials
KW  - combination therapy
KW  - delavirdine
KW  - didanosine
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - nucleoside analogues
KW  - nucleosides
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - analogs
KW  - AZT
KW  - chemotherapy
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - multimodal treatment
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006874&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Potent activity of 2′-β-fluoro-2′,3′-dideoxyadenosine against human immunodeficiency virus type 1 infection in hu-PBL-SCID mice.
AU  - Ruxrungtham, K.
AU  - Boone, E.
AU  - Ford, H., Jr.
AU  - Driscoll, J. S.
AU  - Davey, R. T., Jr.
AU  - Lane, H. C.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1996///
VL  - 40
IS  - 10
SP  - 2369
EP  - 2374
SN  - 0066-4804
AD  - Ruxrungtham, K.: Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20892-1894, USA.
N1  - Accession Number: 19972000704.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 4097-22-7, 30516-87-1. 
N2  - A new antiviral agent, 2′-β-fluoro-2′,3′-dideoxyadenosine (FddA) was evaluated in vivo for anti-HIV activity when administered prior to infection of severe combined immunodeficiency (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID). Following a challenge with 50 × 100% tissue culture infective doses of HIV-1 lymphadenopathy-associated virus, 39 of 42 (93%) control mice developed HIV infection, as shown by positive coculture or positive PCR. Administration of zidovudine decreased the infection rate to 5 of 16 (31%), while administration of FddA decreased the infection rate to 0 of 44. In follow-up controlled studies, the anti-HIV activity of FddA was confirmed, with 18 of 20 control mice showing evidence of HIV infection, compared with 4 of 20 FddA-treated mice. In addition to having direct anti-HIV effects, FddA had a protective effect on human CD4+ T cells in HIV infection. Mice treated with FddA had a significantly higher percentage of CD4+ T cells than controls (10.3%±3.4% vs. 0.27%±0.21%; P=0.01). It is concluded that FddA, with its potent anti-HIV activity in vivo, high oral bioavailability, long intracellular half-life and ability to preserve CD4+ cells in the presence of HIV, appears to be a promising agent for clinical investigation.
KW  - antiviral agents
KW  - antiviral properties
KW  - dideoxyadenosine
KW  - drug therapy
KW  - enzyme inhibitors
KW  - experimental infections
KW  - HIV-1 infections
KW  - human immunodeficiency viruses
KW  - reverse transcriptase inhibitors
KW  - treatment
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anti-viral properties
KW  - AZT
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000704&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type 1 isolates from patients and rapid screening procedure for their detection.
AU  - Vasudevachari, M. B.
AU  - Zhang, Y. M.
AU  - Imamichi, H.
AU  - Imamichi, T.
AU  - Falloon, J.
AU  - Salzman, N. P.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1996///
VL  - 40
IS  - 11
SP  - 2535
EP  - 2541
SN  - 0066-4804
AD  - Vasudevachari, M. B.: Laboratory of Molecular Retrovirology, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972000064.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 150378-17-9. 
N2  - A rapid procedure for the detection of drug-resistant variants in patients on protease inhibitor therapy, based on the loss of 2 HindII restriction enzyme digestion sites, was used to detect the emergence of mutated viruses at various times after the initiation of therapy with the HIV-1 protease inhibitor indinavir. The method included viral RNA isolation from plasma and reverse transcription polymerase chain reaction (PCR) amplification of the protease gene with fluorescence-tagged primers. The PCR product was digested with HindII, the cleavage products were separated on a urea-acrylamide gel in a DNA sequencer and the extent of cleavage was automatically analysed with commercially available software. In viruses from 34 blood samples from 4 patients, mutations leading to an amino acid change at residue 82 appeared as early as 6 weeks after the start of therapy and persisted throughout the course of the study period (48 weeks). Mutations leading to double substitutions at residues 82 and 90 were seen at a lower frequency and appeared later than the change at position 82. The changes detected by restriction enzyme cleavage were confirmed by DNA sequencing of the cloned protease genes by reverse transcription PCR amplification of viral RNA from isolates in plasma. In addition to the changes at positions 82 and 90 M46L/I, G48V, and I54V substitutions were identified in isolates derived from indinavir-treated patients. HindII analysis of uncloned, PCR-amplified DNA could be a useful rapid screening procedure for the detection of virus isolates containing mutations at amino acid residues 82 and 90 in the HIV-1 protease gene.
KW  - analytical methods
KW  - detection
KW  - drug resistance
KW  - drug therapy
KW  - genes
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - indinavir
KW  - mutations
KW  - nucleotides
KW  - polymerase chain reaction
KW  - proteinase inhibitors
KW  - proteinases
KW  - screening
KW  - techniques
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - PCR
KW  - protease inhibitors
KW  - proteases
KW  - screening tests
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000064&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A benzoic acid glycoside from Geniostoma antherotrichum.
AU  - Rashid, M. A.
AU  - Gustafson, K. R.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Phytochemistry
JF  - Phytochemistry
Y1  - 1996///
VL  - 41
IS  - 4
SP  - 1205
EP  - 1207
SN  - 0031-9422
AD  - Rashid, M. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Bldg 1052, Rm. 121, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19960303134.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Registry Number: 65-85-0.  Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - A glycoside derivative was isolated from an HIV [human immunodeficiency virus]-inhibitory extract of G. antherotrichum (collected from Papua New Guinea). Its structure was characterized as 2-hydroxy-3-O-β-D-glucopyranosyl-benzoic acid from spectral data. This compound was inactive in the National Cancer Institute's primary anti-HIV screen. The HIV-inhibitory activity of the extract was due to polymeric tannins.
KW  - antiviral plants
KW  - antiviral properties
KW  - benzoic acid
KW  - chemical structure
KW  - glycosides
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - medicinal properties
KW  - phenolic compounds
KW  - plant composition
KW  - plant extracts
KW  - tannins
KW  - Papua New Guinea
KW  - Loganiaceae
KW  - plants
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - ACP Countries
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - New Guinea
KW  - Melanesia
KW  - Australasia
KW  - Oceania
KW  - Pacific Islands
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - drug plants
KW  - Geniostoma
KW  - Geniostoma antherotrichum
KW  - heterosides
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - tannic acid
KW  - Plant Composition (FF040) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960303134&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A 2 week pair-fed study of early X-irradiation effects on rat major salivary gland function.
AU  - Nagler, R. M.
AU  - Baum, B. J.
AU  - Fox, P. C.
JO  - Archives of Oral Biology
JF  - Archives of Oral Biology
Y1  - 1996///
VL  - 41
IS  - 7
SP  - 713
EP  - 717
SN  - 0003-9969
AD  - Nagler, R. M.: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-1190, USA.
N1  - Accession Number: 19971409190.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - Parotid and submandibular salivary output and body weight were measured in male Wistar rats at 4, 8, 11 and 14 days after 15 Gy X-irradiation of the head and neck. Comparisons were made with 2 groups: a non-irradiated group with food and water intake restricted to that of the irradiated group (pair-fed) and a non-irradiated, ad libitum-fed control group. Parotid saliva output was significantly decreased in the irradiated group at 4, 8 and 11 days compared with the control group. The pair-fed rats also had significantly decreased parotid output at these time points and their parotid function did not differ from that of the irradiated rats. At 14 days, all 3 groups demonstrated similar parotid function. Submandibular salivary output was not affected to the same extent. Only at a single time point (11 days) was flow significantly decreased in the irradiated group. Total body weight was less than that of control rats for the irradiated and pair-fed rats at all time points. It is suggested that the early effects of radiation on salivary glands are due, in part, to limited intake of food and water during the immediate post-irradiation period.
KW  - body weight
KW  - food intake
KW  - irradiation
KW  - mandibular glands
KW  - parotid gland
KW  - radiation
KW  - saliva
KW  - salivary glands
KW  - water intake
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - function
KW  - salivary secretions
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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ER  - 

TY  - GEN
T1  - Breakthrough fungemia due to Hansenula anomala in a leukemic patient successfully treated with amphotericin B.
AU  - Kunová, A.
AU  - Špánik, S.
AU  - Kollár, T.
AU  - Trupl, J.
AU  - Krčméry, V., Jr.
T2  - Chemotherapy (Basel)
JO  - Chemotherapy (Basel)
JF  - Chemotherapy (Basel)
Y1  - 1996///
VL  - 42
IS  - 2
SP  - 157
EP  - 158
SN  - 0009-3157
AD  - Kunová, A.: Department of Hematology and Microbiology, National Cancer Institute, University of Trnava, Bratislavia, Slovakia.
N1  - Accession Number: 19961202019.  Publication Type: Correspondence.  Language: English.  Number of References: 4 ref. Registry Number: 1397-89-3, 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 46-yr-old woman from Slovakia who developed fever during chemotherapy for acute myelogenous leukaemia and while receiving prophylactic antibiotics and fluconazole. Blood cultures grew H. anomala and intravenous amphotericin B (1 mg/kg daily) was started. Blood cultures continued to be positive for H. anomala for 5 d, after which a central venous catheter was removed. Symptoms resolved after 25 d of amphotericin B therapy (total dose of 1725 g).
KW  - amphotericin B
KW  - antifungal agents
KW  - blood
KW  - case reports
KW  - drug therapy
KW  - fluconazole
KW  - fungaemia
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - leukaemia
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - therapy
KW  - women
KW  - Slovakia
KW  - man
KW  - Pichia anomala
KW  - Saccharomycetaceae
KW  - Hansenula
KW  - Pichiaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Pichia
KW  - blood cancer
KW  - chemotherapy
KW  - fungemia
KW  - fungistats
KW  - fungus
KW  - Hansenula anomala
KW  - leucaemia
KW  - leukemia
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Lipid requirements and lipid uptake by Giardia lamblia trophozoites in culture.
AU  - Luján, H. D.
AU  - Mowatt, M. R.
AU  - Nash, T. E.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1996///
VL  - 43
IS  - 3
SP  - 237
EP  - 242
SN  - 1066-5234
AD  - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, Maryland 20892-0425, USA.
N1  - Accession Number: 19960804841.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 57-88-5.  Subject Subsets: Protozoology; Tropical Diseases
N2  - To investigate the lipid requirements of Giardia lamblia [G. duodenalis] trophozoites and the mechanisms of lipid uptake, serum-free TYI-S-33 medium was supplemented with lipids incorporated into different lipid carriers. It was found that serum lipoproteins, β-cyclodextrins and bile salts are able to supply cholesterol and phospholipids to Giardia and support the multiplication of the parasite in vitro. Growth rates obtained with different lipoproteins or bile salts and lipid mixtures were similar to that in standard culture medium containing serum. Pulse labelling experiments using fluorescent lipid analogues demonstrated that Giardia can take up lipids from lipoproteins, β-cyclodextrins or bile salt micelles, but with different kinetics, and that bile salts greatly facilitated lipid transfer from lipoproteins and cyclodextrins to the parasite surface. The binding of different radioiodinated lipoprotein classes to the trophozoite surface, inhibition of lipoprotein interiorization at 4°C or by cytochalasin D, and incorporation studies using fluorescent low density lipoproteins suggested that a small component of lipid uptake was probably due to endocytosis of lipoproteins.
KW  - bile salts
KW  - binding
KW  - cholesterol
KW  - culture media
KW  - endocytosis
KW  - lipid absorption
KW  - lipids
KW  - lipoproteins
KW  - nutrient requirements
KW  - nutrient uptake
KW  - nutrients
KW  - parasites
KW  - phospholipids
KW  - physiology
KW  - requirements
KW  - surfaces
KW  - trophozoites
KW  - uptake
KW  - uptake mechanisms
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - dietary standards
KW  - food requirements
KW  - lipins
KW  - nutritional requirements
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804841&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Parasite diversity in an endemic region for avian malaria and identification of a parasite causing penguin mortality.
AU  - McConkey, G. A.
AU  - Li Jun
AU  - Rogers, M. J.
AU  - Seeley, D. C., Jr.
AU  - Graczyk, T. K.
AU  - Cranfield, M. R.
AU  - McCutchan, T. F.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1996///
VL  - 43
IS  - 5
SP  - 393
EP  - 399
SN  - 1066-5234
AD  - McConkey, G. A.: Growth and Development Section, Laboratory of Parasitic Diseases, Building 4, Room B1-28, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970801135.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Veterinary Science; Protozoology; Medical & Veterinary Entomology; Veterinary Science
N2  - The population structure of Plasmodium in vectors and host infections was investigated in an area of intense mortality due to malaria in a captive penguin (Spheniscus demersus) colony, using a polymerase chain reaction method for the identification of Plasmodium species by amplification of ribosomal sequences in DNA or RNA. Three phylogenetically distinct groups of avian Plasmodium were detected in mosquitoes (Culex pipiens and C. restuans) collected at the study site (Baltimore Zoo, Maryland, USA) during a period of high transmission. One of the 3 clades of Plasmodium was found to be prevalent in penguins monitored through the malaria transmission season and was identified on morphological criteria as P. relictum. A complete transmission cycle was defined at the study site as this parasite was directly associated with the death of a penguin. However, phylogenetic comparison of ribosomal sequences to an authenticated reference strain of P. relictum indicated that this was not the parasite causing the penguin mortality and therefore that different Plasmodium species may be morphologically indistinguishable.
KW  - animal diseases
KW  - disease transmission
KW  - disease vectors
KW  - diversity
KW  - epidemiology
KW  - identification
KW  - malaria
KW  - molecular genetics
KW  - morphology
KW  - parasites
KW  - polymerase chain reaction
KW  - protozoal infections
KW  - ribosomal DNA
KW  - ribosomal RNA
KW  - transmission
KW  - zoo animals
KW  - Maryland
KW  - USA
KW  - birds
KW  - Culex
KW  - Culex pipiens
KW  - Culex restuans
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium
KW  - Plasmodium relictum
KW  - protozoa
KW  - Sphenisciformes
KW  - Spheniscus
KW  - Spheniscus demersus
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - Culex
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Plasmodium
KW  - birds
KW  - Spheniscidae
KW  - Sphenisciformes
KW  - Spheniscus
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - biochemical genetics
KW  - mosquitoes
KW  - PCR
KW  - penguins
KW  - protozoal diseases
KW  - rRNA
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Zoo Animals (LL080) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cryptococcal infections of the central nervous system: an analysis of predisposing factors, laboratory findings and outcome in patients from South India with special reference to HIV infection.
AU  - Neelam Khanna
AU  - Chandramuki, A.
AU  - Anita Desai
AU  - Ravi, V.
JO  - Journal of Medical Microbiology
JF  - Journal of Medical Microbiology
Y1  - 1996///
VL  - 45
IS  - 5
SP  - 376
EP  - 379
SN  - 0022-2615
AD  - Neelam Khanna: Department of Microbiology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
N1  - Accession Number: 19971200249.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology; Tropical Diseases
N2  - Predisposing factors, laboratory findings and outcome were assessed in 60 patients with cryptococcal infections of the central nervous system seen at the National Institute of Mental Health and Neurosciences Hospital, Bangalore, India, during January 1978-June 1995. Predisposing factors for Cryptococcus neoformans infection were identified in 36 patients; HIV infection was the most common factor (18). Cryptococcal cultures were positive in all patients. India ink staining was positive in 48 patients and cryptococcal antigen was detected in 35 of 36 patients tested. Comparison of clinical and laboratory parameters between HIV-positive and HIV-negative patients showed that cerebrospinal fluid cell response was poorer, culture of cryptococci from non-neural sites was more frequent and mortality was higher in the HIV-positive group. Although not statistically significant, concurrent systemic infections, especially tuberculosis, were more frequent in the HIV-positive group.
KW  - acquired immune deficiency syndrome
KW  - central nervous system
KW  - clinical aspects
KW  - cryptococcosis
KW  - diagnosis
KW  - HIV infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - meningitis
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - prognosis
KW  - risk factors
KW  - tuberculosis
KW  - Asia
KW  - India
KW  - Karnataka
KW  - Cryptococcus neoformans
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - AIDS
KW  - clinical picture
KW  - CNS
KW  - european blastomycosis
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Mysore
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins.
AU  - Brown, D. R.
AU  - Brousseau, M. E.
AU  - Shamburek, R. D.
AU  - Talley, G. D.
AU  - Meyn, S.
AU  - Demosky, S. J., Jr.
AU  - Santamarina-Fojo, S.
AU  - Brewer, H. B., Jr.
AU  - Hoeg, J. M.
JO  - Metabolism, Clinical and Experimental
JF  - Metabolism, Clinical and Experimental
Y1  - 1996///
VL  - 45
IS  - 12
SP  - 1447
EP  - 1457
SN  - 0026-0495
AD  - Brown, D. R.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bldg 10, Room 7N115, 10 Center Dr, MSC 1666, Bethesda, MD 20892-1666, USA.
N1  - Accession Number: 19971402253.  Publication Type: Journal Article.  Language: English.  Number of References: 92 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - To elucidate the interactions between LDL and HDL in dyslipoproteinaemia a recombinant adenovirus (hLDLR-rAdV) was used to express human LDL receptors (hLDLRs) in LDL receptor-deficient rabbits. hLDLR-rAdV administration resulted in hepatocyte expression and a reduction of total, intermediate-density lipoprotein (IDL) and LDL cholesterol. In addition, hLDLR-rAdV treatment induced increased very-low-density lipoprotein (VLDL) cholesterol, increased VLDL, IDL and LDL triglycerides, decreased α- and pre-β-migrating apolipoprotein E (apo E) and decreased pre-β-migrating apo A-I at 2-4 days posttreatment and increased total plasma apo A-I and pre-β-migrating apo A-I beginning 8-10 days posttreatment. Virtually all plasma apo A-I was present on α- and pre-β-HDL. Pre-β-HDL particles with size and electrophoretic properties consistent with nascent HDL demonstrated the greatest relative apo A-I enrichment following hLDLR-rAdV treatment. It is concluded that enhanced expression of hepatocyte LDLRs by hLDLR-rAdV treatment markedly altered apo A-I-containing lipoproteins and IDL and LDL. The use of recombinant viruses to express physiologically relevant genes in intact rabbits, analogous to transfection of cells in culture, provides a new strategy for the evaluation of effects of specific gene products on metabolic systems in vivo.
KW  - apolipoproteins
KW  - blood
KW  - cholesterol
KW  - gene expression
KW  - genetic vectors
KW  - high density lipoprotein
KW  - hyperlipaemia
KW  - lipoproteins
KW  - liver
KW  - liver cells
KW  - low density lipoprotein
KW  - messenger rna
KW  - receptors
KW  - triacylglycerols
KW  - very low density lipoprotein
KW  - adenoviridae
KW  - rabbits
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cloning vectors
KW  - hepatocytes
KW  - hyperlipemia
KW  - mRNA
KW  - triglycerides
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of human recombinant growth hormone and human recombinant insulin-like growth factor-1 in patients with human immunodeficiency virus infection.
AU  - Hirschfeld, S.
JO  - Hormone Research
JF  - Hormone Research
Y1  - 1996///
VL  - 46
IS  - 4-5
SP  - 215
EP  - 221
SN  - 0301-0163
AD  - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001176.  Publication Type: Journal Article.  Language: English.  Number of References: 105 ref. Registry Number: 9002-72-6. 
KW  - body parts
KW  - clinical aspects
KW  - drug therapy
KW  - hiv infections
KW  - hormones
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nutrition
KW  - somatotropin
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - clinical picture
KW  - growth hormone
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001176&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enhancement of TAT-induced transactivation of the HIV-1 LTR by two genomic fragments of HHV-6.
AU  - GarzinoDemo, A.
AU  - Chen, M.
AU  - Lusso, P.
AU  - Berneman, Z.
AU  - DiPaolo, J. A.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1996///
VL  - 50
IS  - 1
SP  - 20
EP  - 24
SN  - 0146-6615
AD  - GarzinoDemo, A.: Laboratory of Biology and Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972001270.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - The ability of four HHV-6 genomic clones derived from HHV-6 to transactivate the long terminal repeat (LTR) of HIV-1 in two cervical carcinoma cell lines and in a T-lymphoid cell line was tested. Two HHV-6 clones, pZVH-14 and pZVB-70, which were previously shown to increase the expression of human papillomavirus (HPV)-transforming genes, were, per se, weak transactivators of the HIV-1 LTR. However, an increased effect occurred when these clones were combined with the HIV-1 transactivator TAT-1. No such effect was seen with two other HHV-6 clones used as controls. Analysis with HIV-1 LTR deletion mutants indicated that this enhancing effect requires the presence of elements contained in both the enhancer region and the TAT activation region (TAR) of HIV-1. This data may have implications for the potential role of HHV-6 in AIDS and AIDS-related cervical carcinoma.
KW  - acquired immune deficiency syndrome
KW  - carcinoma
KW  - cell lines
KW  - cervix
KW  - clones
KW  - cofactors
KW  - effects
KW  - enhancers
KW  - experiments
KW  - genomes
KW  - human herpesviruses
KW  - human immunodeficiency viruses
KW  - mutants
KW  - neoplasms
KW  - Tat protein
KW  - transactivation
KW  - women
KW  - Herpesviridae
KW  - Human immunodeficiency virus 1
KW  - human papillomaviruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - dsDNA viruses
KW  - DNA viruses
KW  - human immunodeficiency viruses
KW  - Papillomaviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Herpesviridae
KW  - Papillomavirus
KW  - AIDS
KW  - cancers
KW  - human herpesvirus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - human papillomavirus
KW  - long terminal repeat
KW  - Papovaviridae
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Contribution of dieting to the inverse association between energy intake and body mass index.
AU  - Ballard-Barbash, R.
AU  - Graubard, I.
AU  - Krebs-Smith, S. M.
AU  - Schatzkin, A.
AU  - Thompson, F. E.
JO  - European Journal of Clinical Nutrition
JF  - European Journal of Clinical Nutrition
Y1  - 1996///
VL  - 50
IS  - 2
SP  - 98
EP  - 106
SN  - 0954-3007
AD  - Ballard-Barbash, R.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961401678.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Subject Subsets: Human Nutrition
N2  - A study was conducted to examine the association of energy and percentage energy from fat with body mass index (BMI) and determine if self-reported dieting altered observed associations. Dietary intake data based on dietary recalls from 4 nonconsecutive days over a 1 year period were examined relative to BMI. The relation between energy intake and % energy from fat and BMI was examined by linear regression analysis. The sample included 1854 free-living women aged 19-50 years who participated in the 1985-6 Continuing Surveys of Food Intakes by Individuals conducted by the United States Department of Agriculture. Reported energy intake was inversely associated with BMI (regression coefficient (β) = -0.001 24, standard error (s.e.) = 0.00031). Controlling for low energy dieting alone reduced the inverse energy intake-BMI association by about 20% (β = -0.00100, s.e. = 0.00031), compared to reductions of 16, 13 and 10%, respectively, when health status, age and education were added individually to the energy intake - BMI linear regression. Physical activity, smoking status, % energy from fat and report of low fat dieting did not reduce the energy intake-BMI association. Controlling for nondietary factors related to BMI and potentially influencing energy intake reduced the inverse energy intake-BMI association by about 22% (β = -0.00097, s.e. = 0.00025). Further adjustment for low energy dieting on day 1 reduced the inverse energy intake-BMI association by 40% (β = -0.00074, s.e. = 0.00026), suggesting that intermittent energy restriction was a significant factor in the reduced energy intake reported among overweight women. Percent energy from fat was not associated with BMI (β = 0.049, s.e. = 0.025, P=0.055). Exclusion of 37 women reporting poor health status further attenuated the inverse association between energy intake and BMI (β = -0.00064, s.e. = 0.00026), while it strengthened the previously non-significant positive association between % energy from fat and BMI (β = 0.062; s.e. = 0.024). Intermittent energy restriction appeared to be a significant factor in the reduced energy intake reported among overweight women in this sample. Adequate assessment of energy expenditure is required to correctly interpret the association of energy intake to body weight.
KW  - behaviour
KW  - body composition
KW  - body weight
KW  - energy exchange
KW  - energy intake
KW  - feeding behaviour
KW  - obesity
KW  - physical activity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - behavior
KW  - fatness
KW  - feeding behavior
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961401678&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Is Kaposi's sarcoma caused by new herpesvirus?
AU  - Haverkos, H. W.
T2  - Biomedicine & Pharmacotherapy
JO  - Biomedicine & Pharmacotherapy
JF  - Biomedicine & Pharmacotherapy
Y1  - 1996///
VL  - 50
IS  - 6-7
SP  - 318
EP  - 319
SN  - 0753-3322
AD  - Haverkos, H. W.: National Institute on Drug Abuse, National Institutes of Health, Rockville, MD 20857, USA.
N1  - Accession Number: 19972005807.  Publication Type: Correspondence.  Language: English.  Number of References: 15 ref.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human herpesviruses
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - Kaposi's sarcoma
KW  - opportunistic infections
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - AIDS
KW  - human herpesvirus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005807&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunopathogenesis of HIV infection.
AU  - Pantaleo, G.
AU  - Fauci, A. S.
JO  - Annual Review of Microbiology
JF  - Annual Review of Microbiology
Y1  - 1996///
VL  - 50
SP  - 825
EP  - 854
SN  - 0066-4227
AD  - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD 20892-1876, USA.
N1  - Accession Number: 19972003417.  Publication Type: Journal Article.  Language: English.  Number of References: 103 ref.
N2  - The rate of progression of HIV disease may be substantially different among HIV-infected individuals. Following infection of the host with any virus, the delicate balance between virus replication and the immune response to the virus determines both the outcome of the infection, i.e. the persistence versus elimination of the virus, and the different rates of progression. During primary HIV infection, a burst of viraemia occurs that disseminates virus to the lymphoid organs. A potent immune response ensues that substantially, but usually not completely, curtails virus replication. This inability of the immune system to eliminate the virus completely leads to establishment of chronic, persistent infection that over time leads to profound immunosuppression. The potential mechanisms of virus escape from an otherwise effective immune response have been investigated. Clonal deletion of HIV-specific cytotoxic T-cell clones and sequestration of virus-specific cytotoxic cells away from the major site of virus replication represent important mechanisms of virus escape from the immune response that favour persistence of HIV. Qualitative differences in the primary immune response to HIV (i.e. mobilization of a restricted versus broader T-cell receptor repertoire) are associated with different rates of disease progression. Therefore, the initial interaction between the virus and immune system of the host is critical for the subsequent clinical outcome.
KW  - clones
KW  - cytotoxicity
KW  - HIV infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - immunopathology
KW  - infection
KW  - interactions
KW  - pathogenesis
KW  - persistence
KW  - receptors
KW  - replication
KW  - responses
KW  - reviews
KW  - survival
KW  - T lymphocytes
KW  - viraemia
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - follicular dendritic cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - non-progressors
KW  - T cells
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003417&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Severe thrombocytopenia in patients treated with suramin: evidence for an immune mechanism in one.
AU  - Tisdale, J. F.
AU  - Figg, W. D.
AU  - Reed, E.
AU  - McCall, N. A.
AU  - Alkins, B. R.
AU  - Horne, M. K., III
JO  - American Journal of Hematology
JF  - American Journal of Hematology
Y1  - 1996///
VL  - 51
IS  - 2
SP  - 152
EP  - 157
SN  - 0361-8609
AD  - Tisdale, J. F.: Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD20892, USA.
N1  - Accession Number: 19970800534.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 37270-89-6, 9005-49-6, 9041-08-1, 9050-30-0, 308067-58-5, 145-63-1.  Subject Subsets: Protozoology
N2  - The efficacy of the trypanocide suramin against AIDS and various malignancies has been tested. Thrombocytopenia was observed in early trials with suramin in AIDS but has been uncommon in patients treated for solid tumours. It is now reported that 5 of 67 (7%) patients developed severe thrombocytopenia while receiving suramin as part of a phase II clinical trial for metastatic prostate carcinoma refractory to hormonal therapy. IgG purified from the plasma of one patient caused suramin-dependent platelet aggregation. There was also evidence of cross reactivity between suramin and heparin in this system. An immune mechanism was not observed in the other cases, suggesting that multiple mechanisms may be responsible for severe thrombocytopenia in this patient population.
KW  - antiprotozoal agents
KW  - cross reaction
KW  - heparin
KW  - IgG
KW  - immune response
KW  - neoplasms
KW  - parasites
KW  - platelets
KW  - suramin
KW  - thrombocytopenia
KW  - toxicity
KW  - trypanocides
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - blood platelets
KW  - cancers
KW  - heparin sulfate
KW  - heparin sulphate
KW  - immunity reactions
KW  - immunological reactions
KW  - thrombocytes
KW  - trypanocidal drugs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800534&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv20019, secreted from Saccharomyces cerevisiae.
AU  - Kaslow, D. C.
AU  - Sanjai Kumar
JO  - Immunology Letters
JF  - Immunology Letters
Y1  - 1996///
VL  - 51
IS  - 3
SP  - 187
EP  - 189
SN  - 0165-2478
AD  - Kaslow, D. C.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970804491.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Protozoology
N2  - In an effort to develop a protective vaccine the 19-kDa carboxy-terminus of a major merozoite protein of Plasmodium vivax (yPv20019) was expressed as a His6-tagged, secreted polypeptide in Saccharomyces cerevisiae. Seven H-2 congenic mice strains were each given 3 ip injections of 50 µg purified yPv20019 emulsified in either Freund's complete or incomplete adjuvant on days 0, 21 and 31. Serum samples taken from the mice on days 0, 21, 31 and 41 revealed that 5 of the seven H-2 mouse strains elicited antibodies that recognized yeast produced PV20019 by ELISA. Two strains (haplotypes H2b and H2k) remained negative by ELISA after the 3 vaccinations. It is concluded that the vaccine appears to be immunogenic and widely recognized, and to contain one or more helper T cell epitopes that may allow boosting with subsequent natural infections.
KW  - immune response
KW  - immunization
KW  - laboratory animals
KW  - merozoites
KW  - parasites
KW  - recombinant proteins
KW  - recombinant vaccines
KW  - surface proteins
KW  - vaccines
KW  - mice
KW  - Plasmodium vivax
KW  - protozoa
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - membrane proteins
KW  - merozoite surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804491&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice.
AU  - Martinez, A.
AU  - Allegra, C. J.
AU  - Kovacs, J. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1996///
VL  - 54
IS  - 3
SP  - 249
EP  - 252
SN  - 0002-9637
AD  - Martinez, A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, 10 Center Drive MSC 1662, Bethesda, MD 20892-1662, USA.
N1  - Accession Number: 19960803190.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 9002-03-3.  Subject Subsets: Protozoology
N2  - Epiroprim, an inhibitor of dihydrofolate reductase, was evaluated in vitro and in a mouse model of acute infection for activity against Toxoplasma gondii. The 50% inhibitory concentration (IC50) of epiroprim for T. gondii dihydrofolate reductase was 0.9 µM, similar to that of pyrimethamine, but epiroprim was 650-fold more selective than pyrimethamine for T. gondii compared with human dihydrofolate reductase. While intraperitoneally administered epiroprim (300 mg/kg/day for 14 days) alone was ineffective in mice acutely infected with the RH strain of T. gondii, 100% survival was seen when it was combined with orally administered sulfadiazine (375 mg/kg/day), which alone was also ineffective. Increases in survival were seen in combination with doses of sulfadiazine as low as 0.375 mg/kg/day. Orally administered epiroprim combined with dapsone also prolonged survival. It is considered that epiroprim is an active and potentially less toxic alternative to pyrimethamine for the treatment of toxoplasmosis.
KW  - antiprotozoal agents
KW  - dihydrofolate reductase
KW  - drug therapy
KW  - experimental infections
KW  - in vitro
KW  - inhibitors
KW  - laboratory animals
KW  - parasites
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - chemotherapy
KW  - epiroprim
KW  - tetrahydrofolate dehydrogenase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803190&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quantification of Plasmodium falciparum sporozoites by ribosomal RNA detection.
AU  - Vernick, K. D.
AU  - Keister, D. B.
AU  - Toure, A.
AU  - Toure, Y. T.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1996///
VL  - 54
IS  - 4
SP  - 430
EP  - 438
SN  - 0002-9637
AD  - Vernick, K. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesa, MD 20892-0425, USA.
N1  - Accession Number: 19960803447.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 9068-38-6.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Sequences specific to the small subunit ribosomal RNA (SSU rRNA) of the sporogonic stages of P. falciparum were used to design a reverse transcriptase-polymerase chain reaction (RT-PCR) assay that can detect 0.1 sporozoites in total RNA purified from potentially infected mosquitoes (Anopheles gambiae, A. freeborni). A synthetic RNA was made that is amplified in the RT-PCR by the same primers as the parasite SSU rRNA and that serves as an internal control and competitive quantitation standard. The assay was calibrated for quantitation of sporozoites by making a standard curve with RNA from purified and counted sporozoites. The assay accurately measured sporozoite number with a linear range of at least 3 orders of magnitude in a single reaction. Some applications and limitations of the assay are discussed.
KW  - detection
KW  - disease vectors
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - reverse transcriptase
KW  - ribosomal RNA
KW  - sporozoites
KW  - techniques
KW  - Anopheles
KW  - Anopheles freeborni
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - biochemical genetics
KW  - mosquitoes
KW  - PCR
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803447&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Beta-carotene increases lung cancer incidence in cigarette smokers.
AU  - Luca, L. M. de
AU  - Ross, S. A.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1996///
VL  - 54
IS  - 6
SP  - 178
EP  - 180
SN  - 0029-6643
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37 Room 3A-17, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19961408382.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 7235-40-7, 68-26-8.  Subject Subsets: Human Nutrition
N2  - This article reviews 2 clinical trials (in Finland and USA) where cigarette smokers, at a high risk for lung cancer, were given β-carotene supplements. In both studies this resulted in an increase in lung cancer cases.
KW  - antioxidants
KW  - asbestos workers
KW  - beta-carotene
KW  - incidence
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - retinol
KW  - reviews
KW  - supplements
KW  - tobacco smoking
KW  - vitamins
KW  - Finland
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - APEC countries
KW  - North America
KW  - America
KW  - axerophthol
KW  - cancers
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408382&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A new metabolite of retinol: all-trans-4-oxo-retinol as a receptor activator and differentiation agent.
AU  - Ross, S. A.
AU  - Luca, L. M. de
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1996///
VL  - 54
IS  - 11, Part1
SP  - 355
EP  - 359
SN  - 0029-6643
AD  - Ross, S. A.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37, Room 3A-17, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19971404697.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 302-79-4, 68-26-8.  Subject Subsets: Human Nutrition
N2  - This brief critical review discusses the binding and transactivation of retinoic acid receptors by a noncarboxylated retinol metabolite, all-trans-4-oxoretinol, a metabolite of retinol synthesized in mouse embryonal carcinoma F9 cells, which may dispel the notion that retinoic acids are the only transactivators of retinoid receptor-dependant pathways.
KW  - binding
KW  - cell cultures
KW  - cell differentiation
KW  - ligands
KW  - metabolites
KW  - receptors
KW  - retinoic acid
KW  - retinol
KW  - reviews
KW  - transactivation
KW  - vitamins
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - cytodifferentiation
KW  - transcriptional activation
KW  - tretinoin
KW  - vitamin A
KW  - vitamin A acid
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404697&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoic acid response elements as positive and negative regulators of the expression of the homeobox b-1 gene.
AU  - Luca, L. M. de
AU  - Ross, S. A.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1996///
VL  - 54
IS  - 2, I
SP  - 61
EP  - 63
SN  - 0029-6643
AD  - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19961405145.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
KW  - embryogenesis
KW  - retinoic acid
KW  - reviews
KW  - teratogenesis
KW  - tretinoin
KW  - vitamin A acid
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961405145&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cellular and molecular biological analyses of nifurtimox resistance in Trypanosoma cruzi.
AU  - Nozaki, T.
AU  - Engel, J. C.
AU  - Dvorak, J. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1996///
VL  - 55
IS  - 1
SP  - 111
EP  - 117
SN  - 0002-9637
AD  - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970800661.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 23256-30-6.  Subject Subsets: Protozoology
N2  - Nifurtimox resistance was induced in both epimastigotes and tissue culture-derived trypomastigotes of several T. cruzi strains. The magnitude of nifurtimox resistance was strain-dependent. A variety of karyotype changes occurred in the nifurtimox-resistant (NR) strains. Chromosome-specific DNA probes identified karyotype changes common to the NR strains that were moderately resistant to nifurtimox but not the NR strains that were highly resistant to nifurtimox. A marked increase in nifurtimox resistance in one NR strain was accompanied by a 100% increase in nuclear DNA mass and a 50% increase in kinetoplast DNA mass. These data suggest that nifurtimox resistance can be accompanied by a wide spectrum of DNA changes. Both trypanothione reductase and heat-shock proteins may modulate the effects of exposure of T. cruzi to nifurtimox. However, qualitative or quantitative differences were not detected in these genes or their transcripts between the NR strains and the sensitive strains from which they were derived. An understanding of the spectrum of diversity in nifurtimox resistance at the cellular and molecular levels demonstrated in this report is critical in the development of drug therapies against Chagas' disease.
KW  - drug resistance
KW  - in vitro
KW  - nifurtimox
KW  - parasites
KW  - resistance
KW  - protozoa
KW  - trypanosoma cruzi
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800661&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - The role of altered sympathetic nervous system activity in the pathogenesis of obesity.
AU  - Ravussin, E.
AU  - Tataranni, P. A.
JO  - Proceedings of the Nutrition Society
JF  - Proceedings of the Nutrition Society
Y1  - 1996///
VL  - 55
IS  - 3
SP  - 793
EP  - 802
SN  - 0029-6651
AD  - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, RM 541, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19971400892.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 61 ref. Subject Subsets: Human Nutrition
N2  - A review is presented of evidence that the sympathetic nervous system (SNS) may be involved in the regulation of body weight. Topics include: methods to assess SNS activity; SNS activity and obesity; SNS activity and energy expenditure; SNS activity and food intake; and SNS activity and weight gain.
KW  - autonomic nervous system
KW  - body weight
KW  - energy metabolism
KW  - food intake
KW  - nervous system
KW  - obesity
KW  - reviews
KW  - sympathetic nervous system
KW  - weight gain
KW  - man
KW  - rodents
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - parasympathetic system
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400892&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.
AU  - McCormick, J. L.
AU  - McKee, T. C.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1996///
VL  - 59
IS  - 5
SP  - 469
EP  - 471
SN  - 0163-3864
AD  - McCormick, J. L.: National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19960307072.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry
N2  - Two known quinoline alkaloids (buchapine and 3-(3-methyl-2-butenyl)-4-[(3-methyl-2-butenyl)oxy]-2(1H)-quinolinone) and 3 new furoquinoline alkaloids (roxiamines A-C) were isolated from the CH2Cl2-MeOH extract of flowers, leaves and twigs of E. roxburghiana (collected from Thailand) following bioactivity-directed fractionation. Buchapine and 3-(3-methyl-2-butenyl)-4-[(3-methyl-2-butenyl)oxy]-2(1H)-quinolinone protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 values of 0.94 and 1.64 µM, respectively); roxiamines A-C were inactive against HIV-1.
KW  - antiviral properties
KW  - chemical structure
KW  - flowers
KW  - human immunodeficiency viruses
KW  - leaves
KW  - medicinal plants
KW  - plant composition
KW  - quinoline alkaloids
KW  - stems
KW  - Thailand
KW  - Euodia
KW  - Rutaceae
KW  - Rutaceae
KW  - Sapindales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Melicope
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - drug plants
KW  - Euodia roxburghiana
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - Melicope lunu-ankenda
KW  - officinal plants
KW  - Rutales
KW  - Plant Composition (FF040) 
KW  - Non-wood Forest Products (KK540) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960307072&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytotoxic falcarinol oxylipins from Dendropanax arboreus.
AU  - Bernart, M. W.
AU  - Cardellina, J. H., II
AU  - Balaschak, M. S.
AU  - Alexander, M. R.
AU  - Shoemaker, R. H.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1996///
VL  - 59
IS  - 8
SP  - 748
EP  - 753
SN  - 0163-3864
AD  - Bernart, M. W.: Laboratory of Drug Discovery Research and Development, National Cancer Institute-Frederick Cancer Research & Development Center, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19960310830.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Bioassay-guided fractionation of the crude organic extract of leaves of D. arboreus (collected from Puerto Rico) resulted in the isolation of several compounds cytotoxic to a subset of cell lines within the National Cancer Institute's disease-oriented in vitro tumour-screening panel. The major compound responsible for cytotoxicity was falcarinol. Several other known compounds were isolated and found to be cytotoxic, including dehydrofalcarinol, a diynene, falcarindiol and dehydrofalcarindiol. In addition, 2 novel polyacetylenes, dendroarboreols A and B, were isolated and characterized by standard and inverse-detected NMR methods. Compounds were selected from this series for absolute stereochemical determination using the modified Mosher method. Preliminary in vivo evaluations using a LOX melanoma mouse xenograft model were carried out.
KW  - alkynes
KW  - animal models
KW  - cell lines
KW  - chemical structure
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - leaves
KW  - medicinal plants
KW  - neoplasms
KW  - plant composition
KW  - Puerto Rico
KW  - Araliaceae
KW  - mice
KW  - Apiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Araliaceae
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Latin America
KW  - acetylenes
KW  - Araliales
KW  - cancers
KW  - chemical constituents of plants
KW  - Dendropanax
KW  - Dendropanax arboreus
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Porto Rico
KW  - Plant Composition (FF040) 
KW  - Non-wood Forest Products (KK540) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960310830&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii.
AU  - McKee, T. C.
AU  - Fuller, R. W.
AU  - Covington, C. D.
AU  - Cardellina, J. H., II
AU  - Gulakowski, R. J.
AU  - Krepps, B. L.
AU  - McMahon, J. B.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1996///
VL  - 59
IS  - 8
SP  - 754
EP  - 758
SN  - 0163-3864
AD  - McKee, T. C.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, NCI-FCRDC, Bldg. 1052, Rm 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19960310831.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - Four new pyranocoumarins were isolated from extracts of C. lanigerum var. austrocoriaceum and C. teysmannii var. inophylloide (collected from Singapore and Malaysia, respectively). The structural elucidation and anti-HIV activity of calanolide E2, cordatolide E, pseudocordatolide C and calanolide F, along with a simple prenylated coumarin precursor, are described.
KW  - antiviral plants
KW  - antiviral properties
KW  - chemical structure
KW  - coumarins
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - plant composition
KW  - plant extracts
KW  - Malaysia
KW  - Singapore
KW  - Calophyllum
KW  - Clusiaceae
KW  - plants
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Calophyllum
KW  - APEC countries
KW  - ASEAN Countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - Threshold Countries
KW  - anti-viral properties
KW  - Calophyllum lanigerum
KW  - Calophyllum teysmannii
KW  - chemical constituents of plants
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-wood Forest Products (KK540) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960310831&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cold acclimation-associated changes in brown adipose tissue do not necessarily indicate an increase of nonshivering thermogenesis in C57BL/6J mice.
AU  - Talan, M. I.
AU  - Kirov, S. A.
AU  - Clow, L. A.
AU  - Kosheleva, N. A.
JO  - Physiology & Behavior
JF  - Physiology & Behavior
Y1  - 1996///
VL  - 60
IS  - 5
SP  - 1285
EP  - 1289
SN  - 0031-9384
AD  - Talan, M. I.: Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Gerontology Research Center, Russia.
N1  - Accession Number: 19971400366.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
N2  - Non-shivering thermogenesis was examined in C57BL/67 mice that did not improve their cold tolerance after a cold-acclimation procedure (3-h partial restraint at 6°C, repeated 3-times at 2-week intervals). After cold-acclimation, mice were anaesthetized, paralysed and artificially ventilated. Oxygen consumption and carbon dioxide production were examined and metabolic heat production (MHP) was calculated while body temperature was artificially lowered 7.5°C from control. In a separate group of mice, the total amount and concentration of mitochondrial uncoupling protein, thermogenin (UCP), in interscapular brown adipose tissue (BAT) was examined immediately after completion of the cold-acclimation procedure. The concentration and the content of UCP in the mitochondria of interscapular BAT was significantly higher in all mice that had undergone the cold-acclimation procedure, regardless of its outcome, than in mice that had never been exposed to an environment below room temperature (NAIVE). MHP increased significantly during body cooling in all mice. However, MHP before and during cold-acclimation in mice that did not improve their cold tolerance was significantly lower than that in mice in which cold tolerance was improved and was not different from MHP of the NAIVE mice. Thus, in mice in which cold tolerance did not improve after repeated cold exposure, the anatomical and biochemical changes in BAT typical of cold-acclimation were not associated with a cold-induced increase in MHP. It was concluded that the expression of UCP in BAT is a necessary but not sufficient, attribute of cold-acclimation. Cold-acclimation, measured as increased cold tolerance, occurs only if synthesis of UCP in BAT is associated with an increased cold-induced response of the sympathetic nervous system.
KW  - acclimatization
KW  - adipose tissue
KW  - body temperature
KW  - brown fat
KW  - cold
KW  - cold stress
KW  - cold tolerance
KW  - environmental temperature
KW  - heat production
KW  - mitochondria
KW  - regulation
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorigenesis
KW  - thermogenesis
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400366&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body weight: estimation of risk for breast and endometrial cancers.
AU  - Ballard-Barbash, R.
AU  - Swanson, C. A.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1996///
VL  - 63
IS  - SUP 3
SP  - 437S
EP  - 441S
SN  - 0002-9165
AD  - Ballard-Barbash, R.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 343, 6130 Executive Blvd Msc 7344, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19961402728.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Human Nutrition
KW  - body weight
KW  - breast cancer
KW  - endometrium
KW  - estimation
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - obesity
KW  - prognosis
KW  - risk
KW  - weight gain
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - endometrial area
KW  - fatness
KW  - mammary tumour
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402728&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relation of energy, fat, and fiber intakes to plasma concentrations of estrogens and androgens in premenopausal women.
AU  - Dorgan, J. F.
AU  - Reichman, M. E.
AU  - Judd, J. T.
AU  - Brown, C.
AU  - Longcope, C.
AU  - Schatzkin, A.
AU  - Forman, M.
AU  - Campbell, W. S.
AU  - Franz, C.
AU  - Kahle, L.
AU  - Taylor, P. R.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1996///
VL  - 64
IS  - 1
SP  - 25
EP  - 31
SN  - 0002-9165
AD  - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19961406231.  Publication Type: Journal Article.  Language: English.  Number of References: 72 ref. Subject Subsets: Human Nutrition
N2  - Dietary energy, fat and fibre intakes were estimated from 7-day food records completed by 90 premenopausal women on days 14-20 of their menstrual cycles. Fasting blood specimens were collected on days 5-7, 12-15 and 21-23 of each participant's cycle and pooled to create follicular-, midcycle- and luteal-phase samples, respectively, for analysis. Energy intake was associated inversely with plasma androstenedione and dehydroepiandrosterone sulfate (DHEAS), averaged across the 3 menstrual cycle phases, and directly with the probability of a luteal-phase rise in progesterone. For each additional 1 MJ (239 kcal) consumed, androstenedione decreased by 6.0% (95% CI: -8.4, -3.6%), DHEAs decreased by 5.1% (95% CI: -9.6, -0.4%) and the probability of a progesterone rise increased by 60% (95% CI: 5, 145%). After energy intake was adjusted for, the ratio of polyunsaturated to saturated fat (P:S) in the diet was significantly inversely associated with plasma estradiol and estrone during the luteal phase of the menstrual cycle. For each 0.1 increment in the P:S, there was a 7.6% (95% CI: -14.3, -0.5%) decrease in estradiol and a 6.8% (95% CI: -12.7, -0.6%) decrease in estrone. Results support a relation between both energy and fat ingestion and plasma sex hormone concentrations in premenopausal women.
KW  - androgens
KW  - blood
KW  - diet
KW  - diet studies
KW  - energy
KW  - energy intake
KW  - fats
KW  - fibre
KW  - intake
KW  - oestrogens
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - estrogens
KW  - fiber
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406231&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The fluctuation of plasma carotenoid concentrations by phase of the menstrual cycle: a controlled diet study.
AU  - Forman, M. R.
AU  - Beecher, G. R.
AU  - Muesing, R.
AU  - Lanza, E.
AU  - Olson, B.
AU  - Campbell, W. S.
AU  - McAdam, P.
AU  - Raymond, E.
AU  - Schulman, J. D.
AU  - Graubard, B. I.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1996///
VL  - 64
IS  - 4
SP  - 559
EP  - 565
SN  - 0002-9165
AD  - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961410574.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 7488-99-5, 7235-40-7, 57-88-5, 50-28-2, 9002-67-9, 502-65-8, 540-04-5, 27664-65-9, 57-83-0, 68-26-8, 127-40-2, 432-70-2.  Subject Subsets: Human Nutrition
N2  - Non-smoking, premenopausal women (n=12; aged 27±3 years) with confirmed ovulatory cycles were given a standard diet with total carotenoids 10 mg/day for 2 cycles under isoenergetic conditions. Blood was drawn for simultaneous measurement of carotenoids, lipoproteins and hormones on menses days 1-2, 4-6, 11 through 1 day after the luteinizing hormone surge and 7-8 days after the surge, representing the menses, early and late follicular and midluteal phases, respectively. Regression modeling with adjustment for plasma cholesterol concentrations was used to compare mean individual and total plasma carotenoid concentrations by phase of the cycle. Plasma carotenoid concentrations were at their lowest at menses and significantly higher thereafter, except for α-carotene. Compared with plasma concentrations at menses, β-carotene peaked (increased by 9%, P=0.01) in the late follicular phase. Plasma lutein/zeaxanthin and anhydrolutein concentrations were higher by 8-11% (P≤0.006) and by 15-31% (P≤0.02), respectively, during the last 3 phases. Plasma lycopene and phytofluene concentrations peaked (increased by 12%, P=0.004; and by 21%, P=0.006, respectively) at the midluteal phase. This cyclic fluctuation may affect the estimation of the plasma carotenoid-disease relation in studies of premenopausal women.
KW  - alpha-carotene
KW  - beta-carotene
KW  - blood
KW  - carotenoids
KW  - cholesterol
KW  - estradiol
KW  - high density lipoprotein
KW  - lh
KW  - lipoproteins
KW  - low density lipoprotein
KW  - lycopene
KW  - mammary glands
KW  - menstrual cycle
KW  - phytoene
KW  - phytofluene
KW  - plasma
KW  - progesterone
KW  - retinol
KW  - vitamins
KW  - women
KW  - xanthophyll
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - lutein
KW  - luteinizing hormone
KW  - oestradiol
KW  - tetraterpenoids
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Human Reproduction and Development (VV060) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410574&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differences in body composition of black and white girls.
AU  - Yanovski, J. A.
AU  - Yanovski, S. Z.
AU  - Filmer, K. M.
AU  - Hubbard, V. S.
AU  - Avila, N.
AU  - Lewis, B.
AU  - Reynolds, J. C.
AU  - Flood, M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1996///
VL  - 64
IS  - 6
SP  - 833
EP  - 839
SN  - 0002-9165
AD  - Yanovski, J. A.: Warren Grant Magnuson Clinical Center, Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19971401432.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Human Nutrition
N2  - Twenty black and 20 white normal-weight American girls (7-10 years old) were recruited, who were matched for weight, body mass index (BMI), bone age, chronological age, Tanner breast stage and socioeconomic status. Each underwent anthropometric measurements, bioelectrical impedance analysis, dual-energy X-ray absorptiometry (DXA) and abdominal magnetic resonance imaging (MRI) for estimation of total (TAT), visceral (VAT) and subcutaneous (SAT) adipose tissue. Serum lipids and fasting and 2-h oral-glucose-tolerance test (OGTT) glucose and insulin concentrations were also estimated. There were no differences between groups in absolute waist circumference or waist-to-hip ratio, but waist-to-thigh ratio was decreased in black compared with white girls. Black girls had increased bone mineral density and decreased TAT, VAT and SAT compared with whites. VAT was not significantly correlated with any measure of insulin, or with serum lipids. However, basal and 2-h OGTT serum insulin were significantly correlated with SAT, estimated by MRI in black girls (r² = 0.46 for basal insulin, P=0.001; r² = 0.31 for 2-h insulin, P=0.01) but not in white girls. It was concluded that there are significant racial differences in body composition and differences in the strength of association between abdominal adipose tissue depots and insulin sensitivity in black and white girls.
KW  - adipose tissue
KW  - anthropometric dimensions
KW  - blacks
KW  - body composition
KW  - body fat
KW  - children
KW  - ethnic groups
KW  - ethnicity
KW  - girls
KW  - subcutaneous fat
KW  - Maryland
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - anthropometric measurements
KW  - ethnic differences
KW  - United States of America
KW  - Social Structure (UU480) (Discontinued March 2000)
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of dietary fats and fiber on plasma and urine androgens and estrogens in men: a controlled feeding study.
AU  - Dorgan, J. F.
AU  - Judd, J. T.
AU  - Longcope, C.
AU  - Brown, C.
AU  - Schatzkin, A.
AU  - Clevidence, B. A.
AU  - Campbell, W. S.
AU  - Nair, P. P.
AU  - Franz, C.
AU  - Kahle, L.
AU  - Taylor, P. R.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1996///
VL  - 64
IS  - 6
SP  - 850
EP  - 855
SN  - 0002-9165
AD  - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, 6130 Executive Boulevard, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19971401429.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - The effects of fat and fibre consumption on plasma and urine sex hormone concentrations was examined in 43 healthy men (19-56 years old). Men were initially randomly assigned to a low-fat, high-fibre or a high-fat, low-fibre diet for 10 weeks and after a 2-week washout period crossed over to the other diet. Energy content of diets was varied to maintain constant body weight, but averaged ~13.3 MJ/day on both diets. The low-fat diet provided 18.8% of energy from fat with a ratio of polyunsaturated to saturated fat (P:S) of 1.3, whereas the high-fat diet provided 41.0% of energy from fat with a P:S of 0.6. Total dietary fibre consumption from the low- and high-fat diets averaged 4.6 and 2.0 g/MJ daily, respectively. Mean plasma concentrations of total and sex-hormone-binding-globulin (SHBG)-bound testosterone were increased by 13 and 15%, respectively, on the high-fat, low-fibre diet and the difference from the low-fat, high-fibre diet was significant for the SHBG-bound fraction. Men's daily urinary excretion of testosterone also was increased by 13% with the high-fat, low-fibre diet compared with the low-fat, high-fibre diet (P=0.01). Conversely, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were decreased by 12-28% with the high-fat, low-fibre diet (P≤0.01). Results suggest that diet may alter endogenous sex hormone metabolism in men.
KW  - androgens
KW  - binding proteins
KW  - blood
KW  - diet
KW  - fats
KW  - fibre
KW  - hormones
KW  - intake
KW  - men
KW  - metabolism
KW  - neoplasms
KW  - oestrogens
KW  - polyunsaturated fats
KW  - prostate
KW  - saturated fats
KW  - sex hormones
KW  - urine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - carrier proteins
KW  - estrogens
KW  - fiber
KW  - polyenoic fats
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401429&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence.
AU  - Chang, Y. C.
AU  - Penoyer, L. A.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1996///
VL  - 64
IS  - 6
SP  - 1977
EP  - 1983
SN  - 0019-9567
AD  - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961201402.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The isolation and characterization of the gene, CAP64, which is required for capsule formation in C. neoformans, is described. An encapsulated strain created by complementation of the cap64 mutation produced fatal infection in mice within 25 d, while the cap64 acapsular strain was avirulent. Gene deletion of CAP64 from a wild-type strain resulted in the loss of capsule as well as virulence. Contour-clamped homogeneous electric field gel analysis indicated that CAP64 is located on chromosome III, which is different from the localization of another capsule-related gene, CAP59. The non-linkage between CAP64 and CAP59 was also supported by classical recombinational analysis. Database searches did not reveal any sequence with high similarity to CAP64. The CAP64 locus is contiguous to a convergently transcribed gene which has significant similarity to the gene encoding the yeast proteasome subunit, PRE1. The distance between the cDNA ends of these 2 genes is only 22 bp. It is concluded that these results confirm previous molecular genetic evidence that capsule is an essential factor for the virulence of C. neoformans in the murine model of cryptococcosis.
KW  - cryptococcosis
KW  - experimental infections
KW  - genes
KW  - genetics
KW  - infections
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - capsule
KW  - european blastomycosis
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201402&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii.
AU  - Grunvald, E.
AU  - Chiaramonte, M.
AU  - Hieny, S.
AU  - Wysocka, M.
AU  - Trinchieri, G.
AU  - Vogel, S. N.
AU  - Gazzinelli, R. T.
AU  - Sher, A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1996///
VL  - 64
IS  - 6
SP  - 2010
EP  - 2018
SN  - 0019-9567
AD  - Grunvald, E.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960804750.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 130068-27-8, 308079-78-9.  Subject Subsets: Protozoology
N2  - It was shown that a soluble Toxoplasma gondii tachyzoite extract (soluble tachyzoite antigen) can trigger the expression of 4 monokines (IL-12, TNF-α, IL-1β, IL-10) by murine inflammatory macrophages. Further characterization revealed that the parasite molecules in soluble tachyzoite antigen responsible for monokine induction are heat stable at 100°C but differ in sensitivity to protease digestion. Thus, the tachyzoite factors that stimulate TNF-α and IL-1β expression were found to be more resistant to treatment with proteinase K than those responsible for IL-12 and IL-10 induction. Similarly, while the factors responsible for the induction of all 4 monokines were found to be sensitive to periodate oxidation, the TNF-α-stimulating activity was partially resistant to treatment with the compound at a low concentration (1 mM). A further dichotomy in monokine induction signals was inferred from experiments with isoquinoline sulfonamide protein kinase inhibitors. This suggested that the pathways for TNF-α and IL-1β are protein kinase C dependent, whereas expression of IL-12 and expression of IL-10 share distinct signal transduction mechanisms involving other kinases. It is suggested that monokine induction by T. gondii is mediated by glycoproteins that may belong to distinct groups in terms of their biochemical properties and intracellular signalling pathways.
KW  - antigens
KW  - cytokines
KW  - immune response
KW  - interleukin 1
KW  - interleukin 10
KW  - interleukin 12
KW  - macrophages
KW  - parasites
KW  - tachyzoites
KW  - tumour necrosis factor
KW  - protozoa
KW  - Toxoplasma gondii
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - antigenicity
KW  - cachectin
KW  - cachexin
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804750&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Specific induction of fibronectin binding activity by hemoglobin in Candida albicans grown in defined media.
AU  - Yan, S.
AU  - Nègre, E.
AU  - Cashel, J. A.
AU  - Guo, N.
AU  - Lyman, C. A.
AU  - Walsh, T. J.
AU  - Roberts, D. D.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1996///
VL  - 64
IS  - 8
SP  - 2930
EP  - 2935
SN  - 0019-9567
AD  - Yan, S.: Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961201751.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Haemoglobin was shown to be a potent and specific inducer of fibronectin (FN) receptor expression and a defined medium supplemented with haemoglobin that greatly and stably enhances the binding activity of C. albicans for soluble FN is described. Enhancement of FN binding by haemoglobin in strain 44807 was concn-dependent and was maximal at 0.1% haemoglobin with 20- to 80-fold enhancement. The haemoglobin-induced FN binding to C. albicans was saturable, with a Kd of 2.7 × 10-8M. Enhancement required growth of C. albicans in haemoglobin-containing medium, since simply exposing blastoconidia to haemoglobin in a non-growing status did not enhance binding. Induction was reversible following removal of haemoglobin from the growth medium and not associated with germination. Inorganic or protein-bound iron was not sufficient for the induction, since other iron-containing proteins or inorganic iron salts were inactive. Growth in the simple medium yeast nitrogen base supplemented with haemoglobin increased cell adhesion to immobilized FN and to cultured monolayers of bovine corneal endothelial cells. It is suggested that haemoglobin may be an important regulator of FN binding activity in C. albicans and therefore may play a role in its pathogenesis.
KW  - adhesion
KW  - culture media
KW  - endothelium
KW  - fibronectins
KW  - haemoglobin
KW  - matrix proteins
KW  - pathogenesis
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - hemoglobin
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201751&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells.
AU  - Nagineni, C. N.
AU  - Pardhasaradhi, K.
AU  - Martins, M. C.
AU  - Detrick, B.
AU  - Hooks, J. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1996///
VL  - 64
IS  - 10
SP  - 4188
EP  - 4196
SN  - 0019-9567
AD  - Nagineni, C. N.: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 6N 228, Bethesda, Maryland 20892-1596, USA.
N1  - Accession Number: 19960806078.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 10102-43-9, 73-22-3, 308079-78-9, 9008-11-1.  Subject Subsets: Protozoology
N2  - A human retinal pigment epithelial (HRPE) cell in vitro model system was developed to evaluate Toxoplasma gondii replication in ocular toxoplasmosis and the regulation of this replication by cytokines. Replication was quantified by counting the foci of infection (plaque formation) and the numbers of tachyzoites released into the supernatant fluids. Pretreatment of cultures with recombinant human tumour necrosis factor (TNF)-α, interferon (IFN)-α, IFN-β or IFN-γ for 24 h prior to inoculation inhibited T. gondii replication in a dose-dependent manner. Of these cytokines, IFN-γ was the most potent and T. gondii replication was completely inhibited at a concentration of 100 U/ml. The anti-toxoplasmic activity of IFN-γ was significantly blocked by monoclonal antibody to IFN-γ. Treatment of the cultures with IFN-γ from day 1 or 2 pi with T. gondii also offered protection against the parasite. The anti-toxoplasmic activity of TNF-α or IFN-α, -β or -γ in these cultures was independent of the nitric oxide (NO) pathway, since NO production was not found in HRPE cells treated with these cytokines. Addition of tryptophan to IFN-γ-treated cells significantly reversed the inhibitory effects of IFN-γ, suggesting that IFN-γ acts by depleting cellular tryptophan. This effect was confirmed by reverse transcription-PCR and Northern (RNA) blot analysis, which indicated induction of indoleamine 2,3-dioxygenase (IDO), an enzyme that converts tryptophan to kynurenine. The results indicated that interferons inhibit T. gondii replication in HRPE by NO-independent but IDO-dependent mechanisms.
KW  - cell cultures
KW  - cells
KW  - cytokines
KW  - epithelium
KW  - eye diseases
KW  - eyes
KW  - growth inhibitors
KW  - human diseases
KW  - immune response
KW  - in vitro
KW  - interferon
KW  - nitric oxide
KW  - parasites
KW  - recombinant proteins
KW  - retina
KW  - tachyzoites
KW  - toxoplasmosis
KW  - tryptophan
KW  - tumour necrosis factor
KW  - protozoa
KW  - Toxoplasma gondii
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cachectin
KW  - cachexin
KW  - immunity reactions
KW  - immunological reactions
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960806078&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In utero exposure to Onchocerca volvulus: relationship to subsequent infection intensity and cellular immune responsiveness.
AU  - Elson, L. H.
AU  - Days, A.
AU  - Calvopiña, M.
AU  - Paredes, W.
AU  - Araujo, E.
AU  - Guderian, R. H.
AU  - Bradley, J. E.
AU  - Nutman, T. B.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1996///
VL  - 64
IS  - 12
SP  - 5061
EP  - 5065
SN  - 0019-9567
AD  - Elson, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institute of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970802375.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 37341-29-0, 308067-58-5.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Afro-Ecuadorean individuals from an area in northwest Ecuador where Onchocerca volvulus is hyperendemic (73.9% prevalence) were monitored for infection over the past 16 years. To determine whether in utero exposure to O. volvulus biases a child's subsequent immune responses, children aged 9 to 16 years whose mothers' infection status was known were chosen for study. Children of infected mothers (n = 19) had significantly higher levels of skin microfilariae than children of uninfected mothers (n = 13). While serum levels of O. volvulus-specific IgG, IgG subclasses and IgE showed no significant differences between the 2 groups of children, peripheral blood mononuclear cells of children of infected mothers produced higher levels of Th2-type cytokines to several parasite antigens and lower levels of Th1-type cytokines to nonparasite antigens than those of children of uninfected mothers. Therefore, in utero exposure to O. volvulus has a long-term effect on the child's subsequent cellular immune response that may render the child more susceptible to O. volvulus infection postnatally.
KW  - children
KW  - cytokines
KW  - disease prevalence
KW  - epidemiology
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - IgG
KW  - immune response
KW  - immunity
KW  - microfilariae
KW  - mothers
KW  - onchocerciasis
KW  - parasites
KW  - prenatal period
KW  - skin
KW  - T lymphocytes
KW  - Ecuador
KW  - South America
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - dermis
KW  - immunity reactions
KW  - immunological reactions
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802375&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Disruption of the SNF1 gene abolishes trehalose utilization in the pathogenic yeast Candida glabrata.
AU  - Petter, R.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1996///
VL  - 64
IS  - 12
SP  - 5269
EP  - 5273
SN  - 0019-9567
AD  - Petter, R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971200446.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 7440-44-0, 99-20-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - The SNF1 gene product, a serine/threonine protein kinase, is a global regulatory protein which has been isolated from several organisms. In Saccharomyces cerevisiae the SNF1 gene product is essential for the derepression of glucose repression since snf1 strains are unable to utilize sucrose, galactose, maltose, melibiose or non-fermentable carbohydrates. Moreover, the SNF1 gene product was suggested to interact with additional regulatory pathways and to affect the expression of multiple target genes as reflected by the pleiotropic nature of the snf1 mutation. The characterization of the SNF1 homologue of C. glabrata [Torulopsis glabrata], a pathogenic yeast phylogenetically related to S. cerevisiae, is reported. The carbon utilization spectrum of C. glabrata is considerably narrower than that of other pathogenic yeasts and the majority of the strains utilize solely glucose and trehalose from among 20 of the most commonly tested carbohydrates. Disruption of the C. glabrata SNF1 homologue resulted in the loss of the ability to utilize trehalose, indicating that even in an organism with such a limited carbon utilization spectrum, the regulatory mechanism governing catabolic repression is preserved.
KW  - carbon
KW  - genes
KW  - genetics
KW  - physiology
KW  - trehalose
KW  - Candida glabrata
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Torulopsis
KW  - Pezizomycotina
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200446&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?
AU  - Bour, S.
AU  - Schubert, U.
AU  - Peden, K.
AU  - Strebel, K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 2
SP  - 820
EP  - 829
SN  - 0022-538X
AD  - Bour, S.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962003976.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
KW  - envelope glycoproteins
KW  - gene expression
KW  - HIV infections
KW  - human diseases
KW  - regulatory genes
KW  - release
KW  - viral regulatory proteins
KW  - Vpu protein
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003976&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-κB binding and protein kinase C activity in primary human astrocytes.
AU  - Conant, K.
AU  - Ma, M.
AU  - Nath, A.
AU  - Major, E. O.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 3
SP  - 1384
EP  - 1389
SN  - 0022-538X
AD  - Conant, K.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
N1  - Accession Number: 19962005270.  Publication Type: Journal Article.  Language: English.  Number of References: 79 ref. Registry Number: 9026-43-1. 
N2  - Human immunodeficiency virus type 1 (HIV-1) infection has been associated with an increase in the binding of the transcription factor NF-κB to its consensus sequence in the viral promoter. Using cultures of primary human fetal astrocytes, we show that exogenous HIV-1 Tat protein, which has been demonstrated to be released from infected cells, is associated with an increase in the binding of this transcription factor to an HIV-1 long terminal repeat κB sequence. This effect occurs rapidly and is independent of new protein synthesis. We also demonstrate that extracellular Tat protein is associated with an increase in protein kinase C activity. If Tat functions similarly in other cell types, such findings could relate to some of this protein's previously described physiological effects. These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor.
KW  - binding
KW  - HIV-1 infections
KW  - human diseases
KW  - protein kinase
KW  - Tat protein
KW  - transcription factors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Folding, assembly, and intracellular trafficking of the human immunodeficiency virus type 1 envelope glycoprotein analyzed with monoclonal antibodies recognizing maturational intermediates.
AU  - Otteken, A.
AU  - Earl, P. L.
AU  - Moss, B.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 6
SP  - 3407
EP  - 3415
SN  - 0022-538X
AD  - Otteken, A.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0455, USA.
N1  - Accession Number: 19962008138.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref.
N2  - Monoclonal antibodies (MAbs) that bind linear or conformational epitopes on monomeric or oligomeric HIV-1 envelope glycoproteins were screened for their recognition of maturational intermediates. On the basis of reactivities with gp160 at different times after pulse-labelling, the MAbs were sorted into groups that exhibited binding which was immediate and constant, immediate but transient, delayed, late, or very late. This grouping was consistent with the selectivity of the MAbs for structural features of gp160. Thus, a MAb to the V3 loop reacted with envelope proteins at all times, in accord with the relative conformational independence and accessibility of the epitope. Several MAbs that preferentially react with monomeric gp160 exhibited diminished binding after the pulse. A 10-min. lag occurred before gp160 reacted with conformational MAbs that inhibited CD4 binding. The availability of epitopes for other conformational MAbs, including some that react equally with monomeric and oligomeric gp160 and some that react better with oligomeric forms, was half-maximal in 30 min. and closely followed the kinetics of gp160 oligomerization. Remarkably, there was a 1- to 2-h delay before gp160 reacted with stringent oligomer-specific MAbs. After 4 h, approximately 20% of the gp160 was recognized by these MAbs. Epitopes recognized by monomer-specific or CD4-blocking MAbs but not by oligomer-dependent MAbs were present on gp160 molecules associated with the molecular chaperone BiP/GRP78. MAbs with a preference for monomers reacted with recombinant or HIV-1 envelope proteins in the endoplasmic reticulum, whereas the oligomer-specific MAbs recognized them in the Golgi complex. Additional information regarding gp160 maturation and intracellular trafficking was obtained by using brefeldin A, dithiothreitol, and a low temperature.
KW  - conformation
KW  - envelope glycoproteins
KW  - envelope protein gp160
KW  - epitopes
KW  - HIV-1 infections
KW  - human diseases
KW  - monoclonal antibodies
KW  - processing
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenic determinants
KW  - body conformation
KW  - gp160
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008138&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara.
AU  - Hirsch, V. M.
AU  - Fuerst, T. R.
AU  - Sutter, G.
AU  - Carroll, M. W.
AU  - Yang, L. C.
AU  - Goldstein, S.
AU  - Piatak, M. Jr.
AU  - Elkins, W. R.
AU  - Alvord, W. G.
AU  - Montefiori, D. C.
AU  - Moss, B.
AU  - Lifson, J. D.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 6
SP  - 3741
EP  - 3752
SN  - 0022-538X
AD  - Hirsch, V. M.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
N1  - Accession Number: 19962008148.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - The dynamics of plasma viremia were explored in a group of 12 SIV-infected rhesus macaques (Macaca mulatta) that had received prior immunization with either nonrecombinant or trivalent (gag-pol, env) SIV-recombinant vaccinia viruses. Three distinct patterns of viral replication observed during and following primary viremia accounted for significant differences in survival times. High-level primary plasma viremia with subsequently increasing viremia was associated with rapid progression to AIDS (n = 2). A high-level primary plasma virus load with a transient decline and subsequent progressive increase in viremia in the post-acute phase of infection was associated with progression to AIDS within a year (n = 6). Low levels of primary plasma viremia followed by sustained restriction of virus replication were associated with maintenance of normal lymphocyte subsets and intact lymphoid architecture (n = 4), reminiscent of the profile observed in human immunodeficiency virus type 1-infected long-term nonprogressors. Three of four macaques that showed this pattern had been immunized with an SIV recombinant derived from the attenuated vaccinia virus, modified vaccinia virus Ankara. These data link the dynamics and extent of virus replication to disease course and suggest that sustained suppression of virus promotes long-term, asymptomatic survival of SIV-infected macaques. These findings also suggest that vaccine modulation of host immunity may have profound beneficial effects on the subsequent disease course, even if sterilizing immunity is not achieved.
KW  - animal models
KW  - disease course
KW  - HIV-1 infections
KW  - immune response
KW  - immunization
KW  - survival
KW  - viraemia
KW  - Human immunodeficiency virus 1
KW  - Macaca
KW  - simian immunodeficiency virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008148&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys.
AU  - Men RuHe
AU  - Bray, M.
AU  - Clark, D.
AU  - Chanock, R. M.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 6
SP  - 3930
EP  - 3937
SN  - 0022-538X
AD  - Men RuHe: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970500141.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 63231-63-0.  Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3′ noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne flaviviruses have been identified. A series of deletions that range from 30 to 262 nt were introduced into this upstream region of full-length DEN4 cDNA to create viable deletion mutants, some of which might prove to be useful for inclusion in a live attenuated virus vaccine. When studied by an infectious-centre assay, most full-length RNA transcripts of the deletion constructs exhibited reduced infectivity when transfected into simian LLC-MK2 cells compared with the full-length RNA transcripts of wild-type parental virus. Deletion mutations that extended as far as the 5′ boundary of the 3′ noncoding region and whose 3′ boundary did not extend beyond the last 113 nt of the 3′ end were viable. With the exception of mutant 3′d 303-183, which contained a deletion of nt 303 to 183 from the 3′ terminus, deletion mutants produced plaques that appeared late on simian LLC-MK2 cells or exhibited a small-plaque morphology on Aedes albopictus C6/36 cells compared with the wild-type virus. These mutants also replicated less efficiently and attained a lower titre in LLC-MK2 cells than parental wild-type virus. Significantly, mutant 3′d 303-183 grew to a high titre and was least restricted in growth. Mutant 3′d 303-183 and 4 other moderately to severely restricted mutants were selected for evaluation of infectivity and immunogenicity in rhesus monkeys. There was a suggestion that occurrence and duration of viraemia were reduced for some of the deletion mutants compared with the wild-type virus. However, more convincing evidence for attenuation of some of the mutants was provided by an analysis of antibody response to infection. Mutant 3′d 303-183 induced an antibody response equivalent to that stimulated by wild-type virus, whereas other mutants induced low to moderate levels of antibodies, as measured by radio-immunoprecipitation and virus neutralization. The immunogenicity of these 3′ DEN4 deletion mutants in monkeys appeared to correlate with their efficiency of growth in simian LLC-MK2 cells. One or more mutants may prove to be useful for immunization of humans against disease caused by dengue virus.
KW  - arboviruses
KW  - cell culture
KW  - cell lines
KW  - immune response
KW  - infection
KW  - laboratory animals
KW  - mutants
KW  - RNA
KW  - viraemia
KW  - Aedes albopictus
KW  - Culicidae
KW  - dengue 4 virus
KW  - dengue virus
KW  - Diptera
KW  - Macaca mulatta
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - arthropod-borne viruses
KW  - Asian tiger mosquito
KW  - immunity reactions
KW  - immunological reactions
KW  - mosquitoes
KW  - ribonucleic acid
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500141&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Monkeys immunized with intertypic chimeric dengue viruses are protected against wild-type virus challenge.
AU  - Bray, M.
AU  - Men RuHe
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 6
SP  - 4162
EP  - 4166
SN  - 0022-538X
AD  - Bray, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970500140.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - The current strategy for dengue immunization favours the use of a vaccine containing each of the 4 serotypes. The authors previously employed full-length dengue type 4 virus (DEN4) cDNA to construct a viable intertypic dengue virus of type 1 or type 2 antigenic specificity that contained the genes for the capsid-premembrane-envelope (C-pre-M-E) structural proteins of DEN1 or pre-M and E structural proteins of DEN2 substituting for the corresponding DEN4 genes. Chimaeras DEN1/DEN4 and DEN2/DEN4, which express the nonstructural proteins of DEN4 and the C-pre-M-E structural proteins of DEN1 or the pre-M-E structural proteins of DEN2, and therefore the antigenicity of type 1 or type 2, were used to immunize rhesus monkeys. Other monkeys were inoculated with parental DEN1, DEN2 or cDNA-derived DEN4. Three of 4 monkeys immunized with DEN1/DEN4 developed neutralizing antibodies against DEN1 and were protected against subsequent DEN1 challenge. All 4 monkeys immunized with DEN2/DEN4 developed antibodies against DEN2 and were protected against subsequent DEN2 challenge. DEN1- and DEN2-immunized monkeys were protected against homologous virus challenge, but DEN4-immunized animals became viraemic on cross-challenge with DEN1 or DEN2. In a 2nd experiment, 8 monkeys were immunized with equal mixtures of DEN1/DEN4 and DEN2/DEN4. Each of these monkeys developed neutralizing antibodies against both DEN1 and DEN2 and were protected against subsequent challenge with DEN1 or DEN2. Chimaeric dengue viruses could be used to express serotype-specific antigens in a live attenuated tetravalent human vaccine.
KW  - arboviruses
KW  - chimaeras
KW  - genes
KW  - immunization
KW  - laboratory animals
KW  - vaccines
KW  - viral proteins
KW  - dengue 1 virus
KW  - dengue 2 virus
KW  - dengue 4 virus
KW  - dengue virus
KW  - Macaca mulatta
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - chimeras
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500140&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resistance of previously infected chimpanzees to successive challenges with a heterologous intraclade B strain of human immunodeficiency virus type 1.
AU  - Shibata, R.
AU  - Siemon, C.
AU  - Cho, M. W.
AU  - Arthur, L. O.
AU  - Nigida, S. M., Jr.
AU  - Matthews, T.
AU  - Sawyer, L. A.
AU  - Schultz, A.
AU  - Murthy, K. K.
AU  - Israel, Z.
AU  - Javadian, A.
AU  - Frost, P.
AU  - Kennedy, R. C.
AU  - Lane, H. C.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 7
SP  - 4361
EP  - 4369
SN  - 0022-538X
AD  - Shibata, R.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972005478.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 9007-49-2, 63231-63-0. 
N2  - To test whether the protective effects of attenuated simian immunodeficiency virus vaccines in macaques were applicable to the HIV-1-chimpanzee system, two groups of animals, previously infected with HIV-1IIIB or HIV-1SF2, were each challenged with a heterologous clade B virus, HIV-1DH12. Following challenge, the parameters measured included virus isolation (from plasma. peripheral blood mononuclear cells, and lymph node tissue); quantitative DNA PCR using primers capable of distinguishing HIV-1IIIB, HIV-1SF2, and HIV-1DH12 from one another; and serological assays to monitor changes in binding and neutralizing antibodies. In contrast to an HIV-1-naive chimpanzee that rapidly became infected following the inoculation of HIV-1DH12, the two chimpanzees previously infected with HIV-1IIIB resisted repeated and escalating inoculations of HIV-1DH12, as monitored by virus isolation and PCR. The two animals previously infected with HIV-1SF2 became infected with HIV-1DH12, but in contrast to the case with the HIV-1-naive chimpanzee, no cell-free viral RNA was detected in the plasma by the branched DNA procedure and levels of peripheral blood mononuclear cell-associated viral DNA were reduced 35- to 50-fold.
KW  - DNA
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - neutralizing antibodies
KW  - RNA
KW  - vaccines
KW  - viral load
KW  - chimpanzees
KW  - Human immunodeficiency virus 1
KW  - Pan
KW  - Pongidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005478&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - cis-acting elements in human immunodeficiency virus type 1 RNAs direct viral transcripts to distinct intranuclear locations.
AU  - Berthold, E.
AU  - Maldarelli, F.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 7
SP  - 4667
EP  - 4682
SN  - 0022-538X
AD  - Berthold, E.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972005475.  Publication Type: Journal Article.  Language: English.  Number of References: 75 ref. Registry Number: 63231-63-0. 
N2  - Two distinct intranuclear locations were identified for alternatively spliced RNA transcripts expressed from the pNL4-3 infectious molecular clone of human immunodeficiency virus (HIV) type 1. Multiply spliced HIV RNA encoding tat was detected within the nucleus in large clusters; immunostaining and colocalization studies using laser-scanning confocal microscopy revealed that these structures contained the non-small nuclear ribonucleoprotein RNA processing factor, SC35. In contrast, unspliced gag RNA was detected in much smaller granules distributed throughout the nucleus, with little or no association with SC35-containing granules. Analyses of nuclear RNA expressed from recombinant plasmids encoding gag (pCMVgag-2) alone or tat (pCMVtat-2) alone revealed distributions corresponding to those obtained with pNL4-3, indicating that expression within the context of the HIV provirus was not required for the distinct RNA locations detected for these transcripts. The presence of unspliced gag RNA in small granules was confirmed in infections of H9 T-lymphocytic cells, indicating that gag localization was not restricted to transient expression systems. The intranuclear distribution of gag RNA was dependent on specific RNA sequences. Deletion of a portion of the gag gene of pCMVgag-2, containing a cis-repressing inhibitory region, resulted in redirection of unspliced gag RNA from small granules into large SC35-containing clusters. The addition of the Rev-responsive element, RRE, to the deleted pCMVgag-2 construct resulted in RNA transcripts which were no longer associated with SC35. An cellular intron, rabbit β-globin-intervening sequence 2 (IVS-2), was also identified which, when introduced into pCMVgag-2, redirected unspliced gag RNA into SC35-containing granules and permitted rev-independent Gag expression. These findings suggest that redirecting intranuclear RNA localization may influence gene expression.
KW  - cells
KW  - gag gene
KW  - HIV-1 infections
KW  - human diseases
KW  - localization
KW  - nuclei
KW  - RNA
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cell nuclei
KW  - DNA transcription
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005475&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract.
AU  - Powell, M. D.
AU  - Levin, J. G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 8
SP  - 5288
EP  - 5296
SN  - 0022-538X
AD  - Powell, M. D.: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Building 6B, Room 216, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962008169.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 9007-49-2. 
N2  - At the 3′ end of all retroviral genomes there is a short, highly conserved sequence known as the polypurine tract (PPT), which serves as the primer for plus-strand DNA synthesis. The authors have identified the determinants for in vitro priming by the HIV-1 PPT. They show that when the PPT is removed and placed into different nucleotide contexts, new priming sites are produced at the precise 3′ end of the PPT. In addition, they found that a hybrid consisting of a 15- or 20-nucleotide RNA primer annealed to a 35-nucleotide DNA template is competent for initiation of plus-strand synthesis with HIV-1 reverse transcriptase. Thus, no cis-acting elements appear to be required for priming activity. Changes at the 5′ end of the PPT have no effect on primer function, whereas the identity of bases at the 3′ end is crucial. A primer containing only the 6 G residues from the 3′ end of the wild-type PPT sequence and 9 bases of random sequence at the 5′ end functions like a wild-type PPT. A short hybrid having a similar helical structure but a primary sequence different from that of the PPT is cleaved imprecisely, resulting in initiation of synthesis at multiple sites; however, total primer extension is close to the wild-type level. The authors conclude that helical structure as well as the presence of particular bases at the 3′ end of the PPT is essential for PPT function.
KW  - DNA
KW  - genomes
KW  - HIV-1 infections
KW  - human diseases
KW  - nucleotide sequences
KW  - structure
KW  - synthesis
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008169&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages.
AU  - Alkhatib, G.
AU  - Broder, C. C.
AU  - Berger, E. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 8
SP  - 5487
EP  - 5494
SN  - 0022-538X
AD  - Alkhatib, G.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 236, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972007819.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - Work in this laboratory previously demonstrated that the tropism of different human immunodeficiency type 1 isolates for infection of human CD4+ continuous cell lines (e.g., T-cell lines and HeLa-CD4 transformants) versus primary macrophages is associated with parallel intrinsic fusogenic specificities of the corresponding envelope glycoproteins (Envs). For T-cell line-tropic isolates, it is well established that the target cell must also contain a human-specific fusion cofactor(s) whose identity is unknown. In this study, we tested the hypothesis that the Env fusion specificities underlying T-cell line versus macrophage tropism are determined by distinct cell type-specific fusion cofactors. We applied a recombinant vaccinia virus-based reporter gene assay for Env-CD4-mediated cell fusion; the LAV and Ba-L Envs served as prototypes for T-cell line-tropic and macrophage-tropic isolates, respectively. We examined CD4+ promyeloctic and monocytic cell lines that are infectible by T-cell line-tropic isolates and become susceptible to macrophage-tropic strains only after treatment with differentiating agents. We observed parallel changes in fusion specificity: untreated cells supported fusion by the LAV but not the Ba-L Env, whereas cells treated with differentiating agents acquired fusion competence for Ba-L. These results suggest that in untreated cells, the block to infection by macrophage-tropic isolates is at the level of membrane fusion; furthermore, the differential regulation of fusion permissiveness for the two classes of Envs is consistent with the existence of distinct fusion cofactors. To test this notion directly, we conducted experiments with transient cell hybrids formed between CD4-expressing nonhuman cells (murine NIH 3T3) and different human cell types. Hybrids formed with HeLa cells supported fusion by the LAV Env but not by the Ba-L Env, whereas hybrids formed with primary macrophages showed the opposite specificity; hybrids formed between HeLa cells and macrophages supported fusion by both Envs. These results suggest the existence of cell type-specific fusion cofactors selective for each type of Env, rather than fusion inhibitors for discordant Env-cell combinations. Finally, analyses based on recombinant protein expression and antibody blocking did not support the proposals by others that the CD44 or CD26 antigens are involved directly in the entry of macrophage-tropic isolates.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007819&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture.
AU  - Neuveut, C.
AU  - Jeang KuanTeh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 8
SP  - 5572
EP  - 5581
SN  - 0022-538X
AD  - Neuveut, C.: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19962008173.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref.
N2  - HIV-1 Tat is essential for virus replication and is a potent trans activator of viral gene expression. Evidence suggests that Tat also influences virus infectivity and cytopathicity. Extensive structure-function studies of Tat in subgenomic settings with point mutagenesis and transient transfection readouts have been performed. These reporter assays have defined certain amino acid residues as being important for trans activation of reporter plasmids. However, they have not directly addressed functions related to virus replication. The authors studied Tat structure-function in the setting of replicating viruses. They characterized mutations that emerged in Tat during HIV-1 infections of T lymphocytes. To ensure that the selection pressure for change was directed toward protein function, they constructed HIV-1s in which the Tat reading frame was freed from constraints exerted by overlapping with the reading frames of vpr, rev, and env. When these recombinant viruses were passaged in T cells, 26 novel nucleotide changes in tat were observed from sequencing of 220 independently isolated clones. Recloning of these changes into a pNL4-3 molecular background allowed for the characterization of residues in Tat important for virus replication. Interestingly, many of the changes that affected replication when they were assayed in transient trans activation of plasmid reporters were found to be relatively neutral. The authors conclude that the structure-function of Tat in virus replication is incompletely reflected by activity measurements based only on subgenomic transient transfections.
KW  - acquired immune deficiency syndrome
KW  - genomes
KW  - HIV-1 infections
KW  - human diseases
KW  - mutations
KW  - replication
KW  - tat gene
KW  - Tat protein
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008173&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function.
AU  - Tabernero, C.
AU  - Zolotukhin, A. S.
AU  - Valentin, A.
AU  - Pavlakis, G. N.
AU  - Felber, B. K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 9
SP  - 5998
EP  - 6011
SN  - 0022-538X
AD  - Tabernero, C.: Human Retrovirus Pathogenesis Group, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19962009114.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 63231-63-0. 
KW  - HIV-1 infections
KW  - human diseases
KW  - RNA
KW  - structure
KW  - transactivation
KW  - Human immunodeficiency virus 1
KW  - simian immunodeficiency virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009114&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.
AU  - Nunn, M. F.
AU  - Marsh, J. W.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 9
SP  - 6157
EP  - 6161
SN  - 0022-538X
AD  - Nunn, M. F.: Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962009119.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
N2  - Although HIV Nef is essential for the induction of AIDS, its biochemical function has remained an enigma. In this study, HIV Nef protein is shown to associate with a serine-threonine kinase that recognizes histone H4 as a substrate, is serologically related to rat p21-activated kinase (PAK), and is specifically activated by Rac and Cdc42. These characteristics define the Nef-associated kinase as belonging to the PAK family. PAKs initiate kinase cascades in response to environmental stimuli, and their identification as a target of Nef implicates these signalling molecules in HIV pathogenesis and provides a novel target for clinical intervention.
KW  - HIV-1 infections
KW  - human diseases
KW  - kinases
KW  - Nef protein
KW  - pathogenesis
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009119&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of Gag precursors and result in the release of noninfectious virus particles.
AU  - Turpin, J. A.
AU  - Terpening, S. J.
AU  - Schaeffer, C. A.
AU  - Gang Yu
AU  - Glover, C. J.
AU  - Felsted, R. L.
AU  - Sausville, E. A.
AU  - Rice, W. G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 9
SP  - 6180
EP  - 6189
SN  - 0022-538X
AD  - Turpin, J. A.: Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, MD 21702, USA.
N1  - Accession Number: 19962009130.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
KW  - antiviral agents
KW  - Gag protein
KW  - HIV-1 infections
KW  - human diseases
KW  - inhibitors
KW  - nucleocapsid proteins
KW  - processing
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - zinc fingers
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009130&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differential glycosylation, virion incorporation, and sensitivity to neutralizing antibodies of human immunodeficiency virus type 1 envelope produced from infected primary T-lymphocyte and macrophage cultures.
AU  - Willey, R. L.
AU  - Shibata, R.
AU  - Freed, E. O.
AU  - Cho, M. W.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 9
SP  - 6431
EP  - 6436
SN  - 0022-538X
AD  - Willey, R. L.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962009122.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref.
KW  - envelope protein gp120
KW  - HIV-1 infections
KW  - human diseases
KW  - lymphocytes
KW  - macrophages
KW  - neutralization
KW  - processing
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - gp120
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009122&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tract.
AU  - Weixing Wu
AU  - Henderson, L. E.
AU  - Copeland, T. D.
AU  - Gorelick, R. J.
AU  - Bosche, W. J.
AU  - Rein, A.
AU  - Levin, J. G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 10
SP  - 7132
EP  - 7142
SN  - 0022-538X
AD  - Weixing Wu: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972007842.  Publication Type: Journal Article.  Language: English.  Number of References: 80 ref.
N2  - In an earlier study on minus-strand DNA synthesis catalyzed by murine leukemia virus reverse transcriptase, we described a prominent pause site near the polypurine tract (J. Guo, W. Wu, Z. Y. Yuan, K. Post, R. J. Crouch, and J. G. Levin, Biochemistry 34:5018-5029, 1995). We now report that pausing at this site is due to a stem-loop structure in the RNA template, formed by interaction of a number of bases in the polypurine tract, including the six G's, and a 3′ sequence which includes four C's. Addition of human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) protein to reverse transcriptase reactions reduces pausing by ~8- to 10-fold and stimulates synthesis of full-length DNA. Thus, NC functions as an accessory protein during elongation of minus-strand DNA and increases the efficiency of DNA synthesis, in this case, by apparently destabilizing a region of secondary structure in the template. Since NC is associated with genomic RNA in the viral core and is likely to be part of a viral replication complex, these results suggest that NC may also promote efficient DNA synthesis during virus replication. Mutational analysis indicates that the features of HIV-1 NC which are important for reduction of pausing include the basic amino acids flanking the first zinc finger, the zinc fingers, and the cysteine and aromatic amino acids within the fingers. These findings suggest that reverse transcription might be targeted by drugs which inactivate the zinc fingers of HIV-1 NC.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007842&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 infection of H9 cells induces increased glucose transporter expression.
AU  - Sorbara, L. R.
AU  - Maldarelli, F.
AU  - Chamoun, G.
AU  - Schilling, B.
AU  - Chokekijcahi, S.
AU  - Staudt, L.
AU  - Mitsuya, H.
AU  - Simpson, I. A.
AU  - Zeichner, S. L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 10
SP  - 7275
EP  - 7279
SN  - 0022-538X
AD  - Sorbara, L. R.: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972007847.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref.
N2  - A clone obtained from a differential display screen for cellular genes with altered expression during human immunodeficiency virus (HIV) infection matched the sequence for the human GLUT3 facilitative glucose transporter, a high-velocity-high-affinity facilitative transporter commonly expressed in neurons of the central nervous system. Northern (RNA) analysis showed that GLUT3 expression increased during infection. Flow cytometry showed that GLUT3 protein expression increased specifically in the HIV-infected cells; this increase correlated with increased 2-deoxyglucose transport in the HIV-infected culture. HIV infection therefore leads to increased expression of a glucose transporter normally expressed at high levels in other cell types and a corresponding increase in glucose transport activity. If HIV infection places increased metabolic demands on the host cell, changes in the expression of a cellular gene that plays an important role in cellular metabolism might provide a more favorable environment for viral replication.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007847&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection of chimpanzee peripheral blood mononuclear cells by human immunodeficiency virus type 1 requires cooperative interaction between multiple variable regions of gp120.
AU  - Cho, M. W.
AU  - Shibata, R.
AU  - Martin, M. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 10
SP  - 7318
EP  - 7321
SN  - 0022-538X
AD  - Cho, M. W.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.
N1  - Accession Number: 19972007850.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref.
N2  - We have recently reported the isolation and molecular cloning of a human immunodeficiency virus type 1 isolate (HIV-1DH125) that exhibits rapid replication kinetics and marked cytopathicity in both human and chimpanzee peripheral blood mononuclear cells (PBMC). To identify the viral determinants responsible for infectivity of chimpanzee PBMC, chimeric viruses containing the following components were constructed: (i) the entire envelope gene; (ii) gp120 sequences; (iii) gp41 sequences; and (iv) individual or various combinations of the gp120 variable regions of HIV-1DH125 inserted into the backbone of another HIV-1 isolate (HIV-1AD8), which is unable to infect chimpanzee PBMC. Analyses of virus replication kinetics in human and chimpanzee PBMC revealed that gp120 contains determinants which confer infectivity for chimpanzee PBMC and that the capacity to establish such an infection requires the cooperative interaction between multiple variable regions of the HIV-1DH125 gp120.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007850&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.
AU  - Ott, D. E.
AU  - Coren, L. V.
AU  - Kane, B. P.
AU  - Busch, L. K.
AU  - Johnson, D. G.
AU  - Sowder, R. C., II
AU  - Chertova, E. N.
AU  - Arthur, L. O.
AU  - Henderson, L. E.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 11
SP  - 7734
EP  - 7743
SN  - 0022-538X
AD  - Ott, D. E.: AIDS Vaccine Program, SAIC/Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001697.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 51 ref.
N2  - The authors identified three types of cytoskeletal proteins inside HIV-1 virions by analysing subtilisin-digested particles. HIV-1 virions were digested with protease, and the treated particles were isolated by sucrose density centrifugation. This method removes both exterior viral proteins and proteins associated with microvesicles that contaminate virion preparations. Since the proteins inside the virion are protected from digestion by the viral lipid envelope, they can be isolated and analysed after treatment. Experiments presented here demonstrated that this procedure removed more than 95% of the protein associated with microvesicles. Proteins in digested HIV-1MN particles from infected H9 and CEMSS cell lines were analysed by high-pressure liquid chromatography, protein sequencing, and immunoblotting. The data revealed that three types of cytoskeletal proteins are present in virions at different concentrations relative to the molar level of Gag: actin (approximately 10 to 15%), ezrin and moesin (approximately 2%), and cofilin (approximately 2 to 10%). Analysis of proteins within virus particles detected proteolytic fragments of α-smooth muscle actin and moesin that were cleaved at sites which might be recognized by HIV-1 protease. These cleavage products are not present in microvesicles from uninfected cells. Therefore, these processed proteins are most probably produced by HIV-1 protease digestion. The presence of these fragments, as well as the incorporation of a few specific cytoskeletal proteins into virions, suggests an active interaction between cytoskeletal and viral proteins.
KW  - cytoskeleton
KW  - HIV-1 infections
KW  - human diseases
KW  - interactions
KW  - proteinases
KW  - proteins
KW  - proteolysis
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001697&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Endogenous\italic\Mtv\roman\-encoded superantigens are not required for development of murine AIDS.
AU  - McCarty, T. C.
AU  - Chattopadhyay, S. K.
AU  - Scherer, M. T.
AU  - Fredrickson, T. N.
AU  - Hartley, J. W.
AU  - Morse, H. C., III
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 11
SP  - 8148
EP  - 8150
SN  - 0022-538X
AD  - McCarty, T. C.: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972001943.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref.
N2  - Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumour virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - antigens
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunopathology
KW  - lymphocyte transformation
KW  - pathogenesis
KW  - mice
KW  - murine leukemia virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Gammaretrovirus
KW  - AIDS
KW  - antigenicity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - immunopathogenesis
KW  - superantigens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001943&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.
AU  - Bour, S.
AU  - Strebel, K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 12
SP  - 8285
EP  - 8300
SN  - 0022-538X
AD  - Bour, S.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.
N1  - Accession Number: 19972001446.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
N2  - Identical enhancement of HIV-1 particle release was observed when either Vpu or the envelope glycoprotein of HIV-2ROD was provided in trans to a Vpu mutant of the NL-43(1) molecular clone of HIV-1. This effect was independent of the presence of the HIV-1 envelope protein. HIV-1 Vpu, as well as ROD10 Env, enhanced SIV particle release. The effects of Vpu and ROD10 Env on SIV particle release were indistinguishable and were observed in the context of full-length SIVmac239 and SIV-HIV chimeras. These results further demonstrate that ROD10 Env can functionally complement Vpu with respect to virus release. No evidence was found of CD4 degradation in the presence of ROD10 Env.
KW  - CD4 antigens
KW  - envelope glycoproteins
KW  - hiv infections
KW  - human diseases
KW  - microbiology
KW  - release
KW  - structural genes
KW  - Vpu protein
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - monkeys
KW  - retroviridae
KW  - simian immunodeficiency virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001446&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites.
AU  - Watkins, B. A.
AU  - Buge, S.
AU  - Aldrich, K.
AU  - Davis, A. E.
AU  - Robinson, J.
AU  - Reitz, M. S., Jr.
AU  - Robert-Guroff, M.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 12
SP  - 8431
EP  - 8437
SN  - 0022-538X
AD  - Watkins, B. A.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001461.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - This study analysed mutations at amino acid positions 281 and 582 in the HIV-1 envelope, where substitutions confer resistance to broadly reactive neutralizing antisera from seropositive individuals. Neither of these mutations lies within an antibody-binding site. The authors of this study conclude that the escape of HIV-1 from neutralization by polyclonal sera occurs through alterations at several different epitopes, generally resulting from single amino acid substitutions which influence envelope conformation.
KW  - amino acids
KW  - antibodies
KW  - binding
KW  - CD4 antigens
KW  - conformation
KW  - env gene
KW  - envelope protein gp120
KW  - epitopes
KW  - genetic variation
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - mutations
KW  - neutralization
KW  - resistance
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - antigenic determinants
KW  - body conformation
KW  - CD4
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - gp120
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001461&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes.
AU  - Chesebro, B.
AU  - Wehrly, K.
AU  - Nishio, J.
AU  - Perryman, S.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1996///
VL  - 70
IS  - 12
SP  - 9055
EP  - 9059
SN  - 0022-538X
AD  - Chesebro, B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19972001458.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref.
N2  - In this study the non-syncytium-inducing phenotype in T cells did not always correlate with macrophage tropism. Macrophage tropism appeared to depend on the presence of certain combinations of amino acids at five specific positions within and just outside of the V3 loop itself, whereas syncytium formation in lymphocytes was influenced by substitution of particular residues at two to four positions within V3. In most cases, different V3 amino acid positions were found to influence independently macrophage tropism and syncytium formation in T cells and position 13 was the only V3 location which appeared to influence simultaneously both macrophage tropism and syncytium formation in lymphocytes.
KW  - amino acids
KW  - clones
KW  - envelope glycoproteins
KW  - formation
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphocytes
KW  - macrophages
KW  - mapping
KW  - microbiology
KW  - pathogenesis
KW  - phenotypes
KW  - syncytia
KW  - T lymphocytes
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - cartography
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - V3 loop
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001458&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiology of in situ and invasive breast cancer in women aged under 45.
AU  - Weiss, H. A.
AU  - Brinton, L. A.
AU  - Brogan, D.
AU  - Coates, R. J.
AU  - Gammon, M. D.
AU  - Malone, K. E.
AU  - Schoenberg, J. B.
AU  - Swanson, C. A.
JO  - British Journal of Cancer
JF  - British Journal of Cancer
Y1  - 1996///
VL  - 73
IS  - 10
SP  - 1298
EP  - 1305
SN  - 0007-0920
AD  - Weiss, H. A.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7374, USA.
N1  - Accession Number: 19962005859.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Public Health
N2  - The incidence of in situ breast cancer in the USA has increased rapidly in recent years, even among young women. A population-based case-control study of 1616 breast cancer cases aged under 45 in the USA was used to examine risk factors for in situ, local and regional/distant tumours. Almost 60% of in situ tumours were detected by routine mammograms compared with 18% of local tumours and 8% of regional/distant tumours. After adjustment for screening history and established risk factors, family history of breast cancer in a first-degree relative and African-American race were associated with an increased risk of all stages of breast cancer. The associations with nulliparity, a previous breast biopsy and body mass index were significantly stronger for in situ tumours than for local or regional/distant disease. Alcohol consumption was associated with an increasing trend in risk of regional/distant tumours but not of earlier stage tumours, indicating that alcohol may be involved in late-stage events. Analyses by histological type of in situ tumours suggested that both ductal and lobular carcinoma in situ were associated with most established breast cancer risk factors, and the magnitude of association tended to be greater for the ductal form.
KW  - age differences
KW  - alcohol intake
KW  - breast
KW  - breast cancer
KW  - epidemiology
KW  - human diseases
KW  - neoplasms
KW  - risk factors
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - alcohol consumption
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005859&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Experimental acute adult T cell leukemia-lymphoma is associated with thymic atrophy in human T cell leukemia virus type I infection.
AU  - Simpson, R. M.
AU  - Zhao TongMao
AU  - Hubbard, B. S.
AU  - Sawasdikosol, S.
AU  - Kindt, T. J.
JO  - Laboratory Investigation
JF  - Laboratory Investigation
Y1  - 1996///
VL  - 74
IS  - 3
SP  - 696
EP  - 710
SN  - 0023-6837
AD  - Simpson, R. M.: Laboratory of Immunogenetics, The National Institute of Allergy and Infectious Disease, National Institutes of Health Twinbrook Facility, Rockville, Maryland, USA.
N1  - Accession Number: 19972007606.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007606&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Membrane modifications in erythrocytes parasitized by Plasmodium falciparum.
AU  - Deitsch, K. W.
AU  - Wellems, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1996///
VL  - 76
IS  - 1/2
SP  - 1
EP  - 10
SN  - 0166-6851
AD  - Deitsch, K. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960802859.  Publication Type: Journal Article.  Language: English.  Number of References: 87 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - This review covers: membrane and transport processes of Plasmodium falciparum-infected erythrocytes; cytoadherence and sequestration of parasitized erythrocytes; antigenically variant adhesive molecules of P. falciparum-infected erythrocytes.
KW  - antigenic variation
KW  - cytoadherence
KW  - erythrocytes
KW  - host parasite relationships
KW  - immune evasion
KW  - malaria
KW  - membranes
KW  - parasites
KW  - reviews
KW  - plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - blood red cells
KW  - cell adhesion
KW  - parasite host relationships
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802859&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Distant metastasis from bilharzial bladder cancer.
AU  - Zaghloul, M. S.
JO  - Cancer
JF  - Cancer
Y1  - 1996///
VL  - 77
IS  - 4
SP  - 743
EP  - 749
SN  - 0008-543X
AD  - Zaghloul, M. S.: Radiotherapy Department, National Cancer Institute, Cairo, Egypt.
N1  - Accession Number: 19960805386.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - A total of 357 patients with cancer of the bladder as a result of Schistosoma infection were treated at the National Cancer Institute in Cairo, Egypt, during the period 1981-1990. They were treated with either cystectomy alone, cystectomy preceded by a short course of preoperative radiotherapy (2000 cGy/5 fractions/1 week) or cystectomy followed by postoperative irradiation (5000 cGy/25 fractions/5 weeks or 3750 cGy/30 fractions/2 weeks). These patients were retrospectively analysed. The overall 5-year rate of distant metastasis was 23%, which was essentially the same in the 3 therapeutic groups. Both univariate and multivariate analyses revealed that the independent risk factors for distant metastasis were pelvic lymph node involvement, pathological stage and histopathological grade. Histological type and local pelvic recurrence appeared in the univariate analysis as working risk factors; however, they were proven by multivariate analysis to be dependent on other risk factors. Patients who had none of the independent risk factors had a lower rate of distant metastasis (11%) and a high local control rate (88%). Those who had more than one risk factor had a high distant metastasis rate (51%) and a low local control rate (41%), regardless of the treatment used. The identified independent risk factors determined both the distant metastasis and the local control rates.
KW  - bladder
KW  - disease course
KW  - helminths
KW  - histopathology
KW  - human diseases
KW  - lymph nodes
KW  - metastasis
KW  - neoplasms
KW  - parasites
KW  - pathology
KW  - radiotherapy
KW  - risk factors
KW  - schistosomiasis
KW  - surgery
KW  - urinary tract diseases
KW  - Africa
KW  - Egypt
KW  - man
KW  - Schistosoma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - bilharzia
KW  - bilharziasis
KW  - cancers
KW  - disease progression
KW  - Misr
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - urinary bladder
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805386&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bimodal down-regulation of CD4 in cells expressing human immunodeficiency virus type 1 Vpu and Env.
AU  - Fujita, K.
AU  - Maldarelli, F.
AU  - Silver, J.
JO  - Journal of General Virology
JF  - Journal of General Virology
Y1  - 1996///
VL  - 77
IS  - 10
SP  - 2393
EP  - 2401
SN  - 0022-1317
AD  - Fujita, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972000013.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
N2  - Analysis of clones of HeLa cells stably expressing the HIV-1 envelope gene (env) and the HIV-1 receptor, CD4, revealed that individual clones consisted of 2 distinct populations of cells differing by approx. 10-fold in the level of surface CD4. When high and low CD4-expressing cells were separated by FACS, each subpopulation gave rise to a mixture of high and low CD4-expressing cells after several days in culture. High and low CD4-expressing subpopulations did not differ with respect to the amount of intracellular Env, but there was an inverse correlation between CD4 and another HIV-1 protein encoded by the same segment of the HIV genome, Vpu. High surface CD4 cells had high levels of intracellular CD4, largely in the perinuclear region, and low levels of Vpu with a diffuse staining pattern. Conversely, low surface CD4 cells had low levels of intracellular CD4 with a diffuse staining pattern, and high levels of Vpu, largely in the perinuclear region. Vectors containing mutant versions of either Env or Vpu failed to down-regulate surface CD4.
KW  - cd4 antigens
KW  - clones
KW  - env gene
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - microbiology
KW  - regulation
KW  - regulatory genes
KW  - structural genes
KW  - viral regulatory proteins
KW  - vpu gene
KW  - vpu protein
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - CD4
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of novel sequences and codon usage in Strongyloides stercoralis.
AU  - Moore, T. A.
AU  - Srinivasan Ramachandran
AU  - Gam, A. A.
AU  - Neva, F. A.
AU  - Lu WenHong
AU  - Saunders, L.
AU  - Williams, S. A.
AU  - Nutman, T. B.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1996///
VL  - 79
IS  - 2
SP  - 243
EP  - 248
SN  - 0166-6851
AD  - Moore, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960805467.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Helminthology
N2  - cDNA libraries were constructed from infective filariform and rhabditiform larval stages of Strongyloides stercoralis using a technique that minimized RNA degradation and loss. 57 independent recombinants were characterized and sequenced, and codon usage was analysed. The genome was AT-rich (65% AT, 35% GC). A putative start codon (ATG) was identified in 3 of the 57 sequenced products. A stop codon was identified in all 57 sequences and in 15 of them was associated with a polyadenylated tail. A spliced leader sequence was not identified in any of the recombinants. BLAST analysis identified homologous protein-encoding genes from 28 sequences: 5 were homologous to ribosomal proteins, 14 were homologous to proteins with known function and 9 were homologous to helminth gene products of unknown function. The remaining 29 were identified as novel proteins. There was minimum overlap in the distribution of these homologous proteins between the filariform and rhabditiform larval libraries. Codon usage was significantly different from that in Caenorhabditis elegans and Onchocerca volvulus. There was a very strong bias for codons ending in A or T. [Nucleotide sequence data submitted to GenBank, accession numbers N21778 to N21834].
KW  - codons
KW  - DNA libraries
KW  - helminths
KW  - larvae
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Strongyloides
KW  - Strongyloididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - coding triplet
KW  - codon usage
KW  - DNA sequences
KW  - filariform larvae
KW  - nematodes
KW  - parasitic worms
KW  - rhabditiform larvae
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805467&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples.
AU  - Kirkman, L. A.
AU  - Su XinZhuan
AU  - Wellems, T. E.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1996///
VL  - 83
IS  - 1
SP  - 147
EP  - 149
SN  - 0014-4894
AD  - Kirkman, L. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960804394.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Protozoology
N2  - A simple method of visual colour scanning is reported by which Plasmodium falciparum clones can be rapidly and efficiently detected in the wells of microtitre plates. The method was used to isolate over 1000 recombinant progeny from a P. falciparum cross (HB3 X Dd2). Over 90% of colour-positive wells were found to contain viable parasites (0.5 to 5.0% parasitaemia), whereas the colour-negative wells consistently showed no parasites by microscopy.
KW  - blood
KW  - clones
KW  - genetic diversity
KW  - isolation
KW  - parasites
KW  - samples
KW  - techniques
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Other Invertebrate Culture (Not Aquaculture) (LL030) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Further studies on phorbol ester bioactivity in the Euphorbiaceae.
AU  - Beutler, J. A.
AU  - Alvarado-Lindner, A. B.
AU  - McCloud, T. G.
JO  - Annals of the Missouri Botanical Garden
JF  - Annals of the Missouri Botanical Garden
Y1  - 1996///
VL  - 83
IS  - 4
SP  - 530
EP  - 533
SN  - 0026-6493
AD  - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute, Frederick Cancer Resarch and Development Center, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19970303902.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 9026-43-1.  Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - The taxonomic distribution of phorbol esters was measured in 634 organic extracts, including 36 previously untested genera of the Euphorbiaceae, using a phorbol dibutyrate receptor binding assay (indicating phorbol esters which bind to protein kinase C). This receptor binding assay was more selective than other assays involving the use of whole animals (e.g. mouse ear irritancy assay). Phorbol bioactivity was newly detected in the genera Anthostema, Blachia, Borneodendron, Dichostemma, Spirostachys, Tapoides, Trigonostemon and Wetria.
KW  - anticarcinogenic properties
KW  - biological activity
KW  - chemotaxonomy
KW  - diterpenoids
KW  - enzyme activity
KW  - esters
KW  - plant composition
KW  - plant extracts
KW  - protein kinase
KW  - screening
KW  - taxonomy
KW  - Euphorbiaceae
KW  - Euphorbiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Anthostema
KW  - anti-carcinogenic properties
KW  - bioactivity
KW  - biochemical taxonomy
KW  - Blachia
KW  - Borneodendron
KW  - chemical constituents of plants
KW  - Dichostemma
KW  - screening tests
KW  - Spirostachys
KW  - systematics
KW  - Tapoides
KW  - Trigonostemon
KW  - Wetria
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Non-wood Forest Products (KK540) 
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970303902&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.
AU  - Mahanty, S.
AU  - Luke, H. E.
AU  - Kumaraswami, V.
AU  - Narayanan, P. R.
AU  - Vijayshekaran, V.
AU  - Nutman, T. B.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1996///
VL  - 84
IS  - 2
SP  - 282
EP  - 290
SN  - 0014-4894
AD  - Mahanty, S.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970804278.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 130068-27-8.  Subject Subsets: Helminthology
N2  - Responses to Brugia malayi microfilarial-derived antigens were assessed and compared to responses against adult male and mixed adult antigens of B. malayi in Madras, India (a region endemic for Wuchereria bancrofti filariasis), in 11 patients with lymphatic filariasis manifesting as elephantiasis and 8 asymptomatic microfilaraemic individuals. Proliferative responses to microfilarial and mixed adult antigens were markedly impaired in the asymptomatic individuals. T cell proliferative responses to adult male antigens did not differ significantly between the 2 groups. It was shown that the asymptomatic microfilaraemic individuals exhibited preferentially impaired Th1-type responses to microfilarial antigens and that microfilarial-induced IL-10 may be critical in the down regulation of specific Th1 responses.
KW  - antigens
KW  - cytokines
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - interleukin 10
KW  - lymphatic filariasis
KW  - microfilariae
KW  - parasites
KW  - man
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - stage specificity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804278&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased expression of the molecular chaperone BiP/GRP78 during the differentiation of a primitive eukaryote.
AU  - Luján, H. D.
AU  - Mowatt, M. R.
AU  - Conrad, J. T.
AU  - Nash, T. E.
JO  - Biology of the Cell
JF  - Biology of the Cell
Y1  - 1996///
VL  - 86
IS  - 1
SP  - 11
EP  - 18
SN  - 0248-4900
AD  - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970801466.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Subject Subsets: Protozoology
N2  - Immunological, biochemical and molecular biological approaches were used to analyse the expression of BiP/GRP78, an endoplasmic reticulum (ER)-resident chaperone, during the Giardia lamblia [Giardia duodenalis] life cycle. A MAb specific for Giardia BiP (immunoglobulin heavy chain-binding protein) permitted the visualization of the ER of this protozoan and showed that BiP expression increased simultaneously with the increased expression of CWPs (leucine-rich proteins) during encystation. However, in contrast to the 140-fold increase in levels of CWP transcripts, the steady-state level of BiP mRNA did not increase during encystation. Furthermore, potent inducers of BiP expression in higher eukaryotic cells, including agents that perturb the ER environment, did not affect BiP expression in Giardia. These results, when considered together with the profound changes that occur in the secretory pathway during Giardia encystation, indicate an important role for this molecular chaperone during the differentiation of this primitive eukaryote.
KW  - development
KW  - differentiation
KW  - endoplasmic reticulum
KW  - monoclonal antibodies
KW  - parasites
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retrovirus-elicited interleukin-12 and tumour necrosis factor-α as inducers of interferon-γ-mediated pathology in mouse AIDS.
AU  - Giese, N. A.
AU  - Gazzinelli, R. T.
AU  - Actor, J. K.
AU  - Morawetz, R. A.
AU  - Sarzotti, M.
AU  - Morse, H. C. III
JO  - Immunology
JF  - Immunology
Y1  - 1996///
VL  - 87
IS  - 3
SP  - 467
EP  - 474
SN  - 0019-2805
AD  - Giese, N. A.: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19962008123.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 9008-11-1, 308079-78-9. 
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - interleukin 12
KW  - pathogenesis
KW  - tumour necrosis factor
KW  - mice
KW  - Murine leukemia virus
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - cachectin
KW  - cachexin
KW  - immunity reactions
KW  - immunological reactions
KW  - murine leukaemia virus
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008123&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: association with KS and persistence in patients receiving anti-herpesvirus drugs.
AU  - Humphrey, R. W.
AU  - O'Brien, T. R.
AU  - Newcomb, F. M.
AU  - Nishihara, H.
AU  - Wyvill, K. M.
AU  - Ramos, G. A.
AU  - Saville, M. W.
AU  - Goedert, J. J.
AU  - Straus, S. E.
AU  - Yarchoan, R.
JO  - Blood
JF  - Blood
Y1  - 1996///
VL  - 88
IS  - 1
SP  - 297
EP  - 301
SN  - 0006-4971
AD  - Humphrey, R. W.: Medicine Branch, National Cancer Institute, Bethesda, MD 20892-1906, USA.
N1  - Accession Number: 19962007673.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 9007-49-2, 63585-09-1, 82410-32-0. 
KW  - aetiology
KW  - DNA
KW  - foscarnet sodium
KW  - ganciclovir
KW  - HIV infections
KW  - human diseases
KW  - human herpesviruses
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - causal agents
KW  - deoxyribonucleic acid
KW  - etiology
KW  - human herpesvirus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - trisodium phosphonoformate
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007673&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Non-Hodgkin's lymphoma and sunlight.
AU  - Hartge, P.
AU  - Devesa, S. S.
AU  - Grauman, D.
AU  - Fears, T. R.
AU  - Fraumeni, J. F. Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 5
SP  - 298
EP  - 300
SN  - 0027-8874
AD  - Hartge, P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19962004994.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Public Health
N2  - The results are presented of a study in the USA using mortality data for cutaneous melanoma, non-melanoma skin cancer and non-Hodgkin's lymphoma (NHL) for the period 1970-1989. The data suggest that the overall geographic variation in mortality rates for NHL in the USA does not reflect higher levels of UV radiation, however, the survey could not exclude a subtle association between NHL and sunlight, (for example, if UV radiation acted as a cofactor, if only particular cell types of NHL were affected, or if intermittent rather than cumulative UV radiation exposure altered risk). The study showed that sunlight does not bear the same clear relationship to NHL evident in the geographic variation of cutaneous melanoma and non-melanoma skin cancers. It is concluded that further investigation of the continuing pattern of high mortality rates for NHL in the Plains, the Midwest and certain coastal areas is warranted.
KW  - climate
KW  - cutaneous melanoma
KW  - environment
KW  - epidemiology
KW  - human diseases
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - risk factors
KW  - skin
KW  - skin cancer
KW  - ultraviolet radiation
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - dermis
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Meteorology and Climate (PP500) 
KW  - Human Health and the Environment (VV500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004994&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
AU  - Cereseto, A.
AU  - Diella, F.
AU  - Mulloy, J. C.
AU  - Cara, A.
AU  - Michieli, P.
AU  - Grassmann, R.
AU  - Franchini, G.
AU  - Klotman, M. E.
JO  - Blood
JF  - Blood
Y1  - 1996///
VL  - 88
IS  - 5
SP  - 1551
EP  - 1560
SN  - 0006-4971
AD  - Cereseto, A.: Laboratory of Tumor Cell Biology, Laboratory of Tumor Immunology and Biology, Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972001678.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref. Registry Number: 63231-63-0. 
KW  - cell cycle
KW  - cell lines
KW  - HTLV infections
KW  - human diseases
KW  - immune response
KW  - kinases
KW  - lymphocyte transformation
KW  - pathogenesis
KW  - proteins
KW  - regulation
KW  - responses
KW  - RNA
KW  - T lymphocytes
KW  - Tax protein
KW  - transcription
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - ribonucleic acid
KW  - T cells
KW  - tumour suppressor gene p53
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001678&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Importance of α-carotene, β-carotene, and other phytochemicals in the etiology of lung cancer.
AU  - Ziegler, R. G.
AU  - Colavito, E. A.
AU  - Hartge, P.
AU  - McAdams, M. J.
AU  - Schoenberg, J. B.
AU  - Mason, T. J.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 9
SP  - 612
EP  - 615
SN  - 0027-8874
AD  - Ziegler, R. G.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961407529.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition; Public Health
KW  - aetiology
KW  - antineoplastic agents
KW  - carotenoids
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - vegetables
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancer sites
KW  - cancers
KW  - causal agents
KW  - cytotoxic agents
KW  - etiology
KW  - tetraterpenoids
KW  - vegetable crops
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407529&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relative weight, weight change, height, and breast cancer risk in Asian-American women.
AU  - Ziegler, R. G.
AU  - Hoover, R. N.
AU  - Nomura, A. M. Y.
AU  - West, D. W.
AU  - Wu, A. H.
AU  - Pike, M. C.
AU  - Lake, A. J.
AU  - Horn-Ross, P. L.
AU  - Kolonel, L. N.
AU  - Siiteri, P. K.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 10
SP  - 650
EP  - 660
SN  - 0027-8874
AD  - Ziegler, R. G.: National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892-7374, USA.
N1  - Accession Number: 19961407481.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Subject Subsets: Human Nutrition; Public Health
N2  - The roles of adult height, adiposity and weight change in breast cancer aetiology were examined. Subjects were women of Chinese, Japanese and Filipino ethnicities, aged 20-55 years, living in San Francisco-Oakland, Los Angeles and Oahu, USA during April 1, 1983, through June 30, 1987. 70% of 852 eligible subjects and 75% of 1287 eligible control subjects were interviewed from August 1985 through February 1989. Subjects were asked about current height, usual adult weight and usual weight in each decade of life, excluding the most recent 3 years and any periods of pregnancy. Height, recent adiposity (weight in the current decade of life/height1.5) and recent weight change (between the current and preceding decades of life) were strong predictors of breast cancer risk after adjustment was made for accepted breast cancer risk factors. Risk doubled (relative risk (RR) = 2.01; 95% confidence interval (CI) = 1.16-3.49) over the 7-inch range in height (two-sided P for trend = 0.003), with comparable effects in both premenopausal and postmenopausal women. Except for reduced risk in the heavy, younger women (weight/height1.5 &gt;29 kg/m1.5 and &lt;40 years old), risk was positively associated with usual adult adiposity. Trends in risk became more striking as adiposity in each succeeding decade of adult life was considered. Women in their 50s and in the top quintile of adiposity for their age group had twice the breast cancer risk (RR = 2.13; 95% CI = 1.17-3.87) of women in the bottom quintile (two-sided P for trend = 0.004). Women in their 50s, above the median adiposity for their age group, and with a recent gain of more than 10 pounds had three times the risk (RR = 3.01; 95% CI = 1.45-6.25) of women below the median adiposity and with no recent weight change. Recent weight loss was consistently associated with reduced risk (RRs of about 0.7) relative to no recent weight change. Adult adiposity, weight change, and height are critical determinants of breast cancer risk. Increased adiposity and weight gain in the decade preceding diagnosis are especially influential, suggesting that excess weight may function as a late stage promoter. Weight maintenance and/or reduction as an adult, possibly accompanied by specific changes in diet and physical activity, may have a significant and rapid impact on breast cancer risk.
KW  - body measurements
KW  - body weight
KW  - breast
KW  - breast cancer
KW  - height
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - risk
KW  - risk factors
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - mammary tumour
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407481&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome.
AU  - Coté, T. R.
AU  - Manns, A.
AU  - Hardy, C. R.
AU  - Yellin, F. J.
AU  - Hartge, P.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 10
SP  - 675
EP  - 679
SN  - 0027-8874
AD  - Coté, T. R.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006512.  Publication Type: Journal Article.  Corporate Author: AIDS/Cancer Study Group Language: English.  Number of References: 16 ref. Subject Subsets: Public Health
N2  - AIDS and cancer registry reports at 9 state and local health departments in the USA were linked and the demographics, histology and survival of brain lymphoma cases among persons with or without AIDS were compared. 50 989 AIDS registry reports were matched to 859 398 cancer registry reports (data 1981-90) and 431 patients with both AIDS and brain lymphoma were identified. Among subjects with AIDS, those developing brain lymphoma vs. those without brain lymphoma were more likely to be white and had homosexuality as their only HIV risk factor. Of the 431 patients, 223 developed brain lymphomas during 47 465 person-years of observation after diagnosis of AIDS. The absolute incidence rate of brain lymphoma among persons with AIDS was 4.7/1000 person-years, 3600-fold higher than the base-line rate in the general population. During 1980-89, overall counts of brain lymphoma increased 9-fold. Most of this increase was derived from persons with AIDS, but a substantial increase also occurred among persons without AIDS (0.04/100 000 in 1982 to 0.28/100 000 in 1989). The median survival was shortest for persons with AIDS and brain lymphoma (2 months), was intermediate for persons with brain lymphoma without AIDS (5-7 months), and was longest for those with AIDS without brain lymphoma (14 months).
KW  - acquired immune deficiency syndrome
KW  - brain
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphoma
KW  - North America
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - cerebrum
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006512&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serologic association between human papillomavirus type 16 infection and esophageal cancer in Shaanxi province, China.
AU  - Han ChengLong
AU  - Qiao GuiBin
AU  - Hubbert, N. L.
AU  - Li LiangShou
AU  - Sun ChangSheng
AU  - Wang Yan
AU  - Yan MingXiao
AU  - Xu DeZhong
AU  - Li YuanGui
AU  - Lowy, D. R.
AU  - Schiller, J. T.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 20
SP  - 1467
EP  - 1471
SN  - 0027-8874
AD  - Han ChengLong: Laboratory of Cellular Oncology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972001894.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Tropical Diseases
N2  - A case-control study was conducted in Shaanxi Province, China, an area with a population at high risk for oesophageal cancer, to assess the association of this disease with infection by human papillomavirus type 16 (HPV 16). 90 individuals with oesophageal cancer and 121 cancer-free control subjects were identified among the patients in 2 hospitals in Xi'an. Blood specimens were drawn from all study subjects, and serum was isolated by routine methods. The presence of HPV 16 antibodies in serum samples was determined by use of an ELISA that used baculovirus-derived HPV 16 virus-like particles as the antigen. A similar ELISA that used bovine papillomavirus type 1 (BPV 1) virus-like particles as the antigen controlled for the specificity of HPV 16 seroreactivity. Data from the HPV 16 and the BPV 1 assays were normalized with respect to results obtained in each assay with a control serum of known HPV 16 seroreactivity. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to examine the association between HPV 16 seroreactivity and oesophageal cancer. Reported P values are two-sided. The mean seroreactivity to HPV 16 virus-like particles was significantly higher for the cancer patients than for the control subjects (mean value ± standard deviation = 0.85 ± 0.22 vs. 0.74 ± 0.18; P &lt;0.0001). When the cancer patients and control subjects were compared by sex and age groups, the differences in mean seroreactivity remained statistically significant. The difference in mean seroreactivity to BPV 1 virus-like particles between cancer patients and control subjects was not statistically significant (0.81 ± 0.28 vs. 0.88 ± 0.32; P = 0.12); this result was not altered when sex and age groups were compared. By use of a cutoff point for HPV 16 seropositivity that was established in studies of cervical neoplasia, 24% of the cancer patients were seropositive compared with 7% of the control subjects, yielding a sex-and age-adjusted OR of 4.5 (95% CI = 1.8-11.9). In general, the OR for oesophageal cancer increased with increasing HPV 16 seroreactivity. It is concluded that HPV 16 infection may be a risk factor for oesophageal cancer. Further studies of the association between HPV 16 infection and the incidence of oesophageal cancer are needed.
KW  - aetiology
KW  - ELISA
KW  - epidemiology
KW  - human diseases
KW  - infections
KW  - neoplasms
KW  - oesophageal cancer
KW  - oesophagus
KW  - risk factors
KW  - viral diseases
KW  - Asia
KW  - China
KW  - Shaanxi
KW  - human papillomavirus 16
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Papillomaviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - North Western China
KW  - China
KW  - cancer sites
KW  - cancers
KW  - causal agents
KW  - enzyme linked immunosorbent assay
KW  - esophageal cancer
KW  - esophagus
KW  - etiology
KW  - human papillomavirus
KW  - Papovaviridae
KW  - People's Republic of China
KW  - Shensi
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001894&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent trends in U.S. breast cancer incidence, survival, and mortality rates.
AU  - Chu, K. C.
AU  - Tarone, R. E.
AU  - Kessler, L. G.
AU  - Ries, L. A. G.
AU  - Hankey, B. F.
AU  - Miller, B. A.
AU  - Edwards, B. K.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 21
SP  - 1571
EP  - 1579
SN  - 0027-8874
AD  - Chu, K. C.: Special Population Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972002698.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Public Health
N2  - Mortality data from the National Center for Health Statistics and incidence and survival data by extent of disease from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute, all stratified by patient age, were examined using statistical-regression techniques to determine trends in breast cancer up to 1993. The age-adjusted breast cancer mortality rate for white females in the USA decreased 6.8% from 1989 to 1993. A significant decrease in the slope of the mortality trend of approximately 2% per year was observed in every decade of age from 40 to 79 years of age. Trends in incidence rates were also similar among these age-groups: localized disease rates increased rapidly from 1982 to 1987 and stabilized or increased more slowly thereafter; regional disease rates decreased after 1987; and distant disease rates remained constant over the past 20 years. Three-year relative survival rates increased steadily and significantly for localized and regional disease from 1980 through 1989 for all ages, with no evidence of an increase in slope in the late 1980s. The decrease in the diagnosis of regional disease in the late 1980s in women &gt;40 years probably reflects the increased use of mammography earlier in the 1980s. The increase in survival rates, particularly for regional disease, probably reflects improvements in systemic adjuvant therapy. Statistical modelling indicates that the recent decrease in breast cancer mortality is too rapid to be explained only by the increased use of mammography; likewise, there has been no equivalent dramatic increase in survival rates that would implicate therapy alone. Thus, indications are that both are involved in the recent rapid decline in breast cancer mortality rates in the USA.
KW  - breast
KW  - breast cancer
KW  - diagnosis
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - mortality
KW  - neoplasms
KW  - screening
KW  - survival
KW  - trends
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - screening tests
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002698&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Changing trends in U.S. prostate cancer incidence rates.
AU  - Merrill, R. M.
AU  - Potosky, A. L.
AU  - Feuer, E. J.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 22
SP  - 1683
EP  - 1685
SN  - 0027-8874
AD  - Merrill, R. M.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19972003085.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Public Health
N2  - An analysis of prostate cancer incidence rates in the USA is presented.
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - men
KW  - neoplasms
KW  - prostate
KW  - prostate cancer
KW  - screening
KW  - trends
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - screening tests
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003085&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cigarette smoking among US adults by state and region: estimates from the current population survey.
AU  - Shopland, D. R.
AU  - Hartman, A. M.
AU  - Gibson, J. T.
AU  - Mueller, M. D.
AU  - Kessler, L. G.
AU  - Lynn, W. R.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1996///
VL  - 88
IS  - 23
SP  - 1748
EP  - 1758
SN  - 0027-8874
AD  - Shopland, D. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19972002893.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Public Health
N2  - Smoking prevalence rates among men and women were determined by region and for each of the 50 states of the USA and the District of Columbia from census survey data collected in 1992 and 1993. These rates were compared with rates determined in 1985. Current smoking rates (every day and some days combined) based on 266 988 adults interviewed in 1992-1993 were calculated. Substantial geographic variation existed in rates of current cigarette use among adults within the USA. In general, adults in the southern USA had higher rates of smoking and adults in the western states had lower rates of smoking than adults in the rest of the country, although differences in smoking behaviour between men and women and among various racial and ethnic populations strongly influenced these patterns. Only Kentucky and West Virginia exhibited adult smoking rates (men and women combined) of 30% or higher in 1992-1993; in contrast, in 1985, such rates were reported from 20 states. The only states in which the prevalence was below 20% in 1992-1993 were Utah (17.1%) and California (19.5%). Rates approaching 20% were reported from New Jersey (20.7%), Massachusetts (21.5%), and Nebraska, New York, and Hawaii (22.0% each) in 1992-1993. Rhode Island experienced the greatest relative decline in smoking prevalence from 1985 to 1992-1993, with a calculated relative change of -30.7% (based on a change in rate from 33.5% to 23.2%), followed by Delaware (-25.9%), the District of Columbia and New Jersey (-23.9% each), Connecticut (-23.2%), California (-22.9%), Alaska (-22.8%), Georgia (-22.6%), Massachusetts (-22.1%), and New York (-22.0%). It was concluded that smoking rates are not uniform in the USA but vary considerably from state to state, even within the same region of the country.
KW  - cigarettes
KW  - epidemiology
KW  - geographical variation
KW  - populations
KW  - statistics
KW  - tobacco smoking
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002893&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants.
AU  - Salem, N., Jr.
AU  - Wegher, B.
AU  - Mena, P.
AU  - Uauy, R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 1
SP  - 49
EP  - 54
SN  - 0027-8424
AD  - Salem, N., Jr.: Laboratory of Membrane Bochemistry and Biophycs, National Institute of Alcohol BAuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA.
N1  - Accession Number: 19961408488.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 506-32-1, 25167-62-8.  Subject Subsets: Human Nutrition
N2  - This study explores the capacity of infants to convert 18-carbon essential fatty acids to their elongated and desaturated forms, in vivo. A newly developed gas chromatography/negative chemical ionization/mass spectrometry method employing ²H-labelled essential fatty acids allowed assessment of this in vivo conversion with very high sensitivity and selectivity. The results demonstrate that infants have the capacity to convert dietary essential fatty acids administered enterally as ²H-labelled ethyl esters to their longer-chain derivatives, transport them to plasma, and incorporate them into membrane lipids. The in vivo conversion of linolenic acid (18:2n-6) to arachidonic acid (20:4n-6) is demonstrated in man. All elongases/desaturases necessary for the conversion of linolenic acid (18:3n-3) to docosahexaenoic acid (22:6n-3) are also active in the first week after birth. Although the absolute amounts of n-3 fatty acid metabolites accumulated in plasma are greater than those of the n-6 family, estimates of the endogenous pools of 18:2n-6 and 18:3n-3 indicate that n-6 fatty acid conversion rates are greater than those of the n-3 family. While these data clearly demonstrate the capability of infants to biosynthesize 22:6n-3, a lipid that is required for optimal neural development, the amounts produced in vivo from 18:3n-3 may be inadequate to support the 22:6n-3 level observed in breast-fed infants.
KW  - arachidonic acid
KW  - docosahexaenoic acid
KW  - essential fatty acids
KW  - infants
KW  - metabolism
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - eicosatetraenoic acid
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408488&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells.
AU  - Thornton, A. M.
AU  - Buller, R. M. L.
AU  - DeVico, A. L.
AU  - Wang, I. M.
AU  - Ozato, K.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 1
SP  - 383
EP  - 387
SN  - 0027-8424
AD  - Thornton, A. M.: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962004964.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9008-11-1. 
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - infections
KW  - interferon
KW  - monocytes
KW  - Human immunodeficiency virus 1
KW  - vaccinia virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004964&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.
AU  - Wu YiMin
AU  - Kirkman, L. A.
AU  - Wellems, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 3
SP  - 1130
EP  - 1134
SN  - 0027-8424
AD  - Wu YiMin: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19960802271.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 9002-03-3, 9007-49-2, 58-14-0.  Subject Subsets: Protozoology
N2  - Plasmodium falciparum parasites were transformed with plasmids containing P. falciparum or Toxoplasma gondii dihydrofolate reductase-thymidylate synthase (dhfr-ts) coding sequences that confer resistance to pyrimethamine. Under pyrimethamine pressure, transformed parasites were obtained that maintained the transfected plasmids as unrearranged episomes for several weeks. These parasite populations were replaced after 2 to 3 months by parasites that had incorporated the transfected DNA into nuclear chromosomes. Depending upon the particular construct used for transformation, homologous integration was detected in the P. falciparumdhfr-ts locus (chromosome 4) or in hrp3 and hrp2 sequences that were used in the plasmid constructs as gene control regions (chromosomes 13 and 8, respectively). Transformation by homologous integration prepares the way for targeted gene alterations and deletions that will advance understanding of P. falciparum.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - chromosomes
KW  - dihydrofolate reductase
KW  - DNA
KW  - drug resistance
KW  - genetic transformation
KW  - integration
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - plasmids
KW  - pyrimethamine
KW  - transfection
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - tetrahydrofolate dehydrogenase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802271&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation.
AU  - Bamford, R. N.
AU  - Battiata, A. P.
AU  - Burton, J. D.
AU  - Sharma, H.
AU  - Waldmann, T. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 7
SP  - 2897
EP  - 2902
SN  - 0027-8424
AD  - Bamford, R. N.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1374, USA.
N1  - Accession Number: 19962006783.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 63231-63-0. 
N2  - We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated interleukin (IL) T that requires interleukin (IL) 2 receptor Β-subunit expression for its action. Using anti-cytokine anti-bodies, we demonstrated that IL-T is identical to the simultaneously described IL-15. When compared to activated monocytes, IL-15 mRNA expression was 6- to 10-fold greater in HuT-102 cells. The predominant IL-15 message from HuT-102 is a chimeric mRNA joining a segment of the R region of the long terminal repeat of HTLV-I and the 5′-untranslated region (UTR) of IL-15. Normally, by alternative splicing, this 118-nucleotide R element represents the most 5′ region of several HTLV-I transcripts including tax, rex, and env. The introduction of the R element eliminated over 200 nucleotides of the IL-15 5′-UTR, including 8 of 10 upstream AUGs that are present in normal IL-15 messages. On analysis of the 5′-UTR of normal IL-15, we demonstrated that the presence of these 10 upstream AUGs interferes with IL-15 mRNA translation. Thus, IL-15 synthesis by the adult T-cell leukemia line HuT-102 involves an increase in IL-15 mRNA transcription and translation secondary to the production of an HTLV-I R element fusion message that lacks many upstream AUGs.
KW  - gene expression
KW  - HTLV-I infections
KW  - human diseases
KW  - RNA
KW  - translation
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - interleukin-15
KW  - ribonucleic acid
KW  - RNA translation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006783&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.
AU  - Levine, M.
AU  - Conry-Cantilena, C.
AU  - Wang, Y.
AU  - Welch, R. W.
AU  - Washko, P. W.
AU  - Dhariwal, K. R.
AU  - Park, J. B.
AU  - Lazarev, A.
AU  - Graumlich, J. F.
AU  - King, J.
AU  - Cantilena, L. R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 8
SP  - 3704
EP  - 3709
SN  - 0027-8424
AD  - Levine, M.: Molecular and Clinical Nutrition Section, Building 10, Room 4D52, MSC 1372, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-1372, USA.
N1  - Accession Number: 19971402078.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 69-93-2, 50-81-7.  Subject Subsets: Human Nutrition
N2  - An in-hospital depletion-repletion study was conducted in 7 healthy men (20-26 years old) who were hospitalized for 4-6 months and consumed a diet containing &lt;5 mg of vitamin C daily. Steady-state plasma and tissue concentrations were determined at 7 daily doses of vitamin C from 30 to 2500 mg. Vitamin C steady-state plasma concentrations as a function of dose displayed sigmoid kinetics. The steep portion of the curve occurred between the 30- and 100-mg daily dose, the current RDA of 60 mg daily was on the lower third of the curve, the first dose beyond the sigmoid portion of the curve was 200 mg daily, and complete plasma saturation occurred at 1000 mg daily. Neutrophils, monocytes and lymphocytes saturated at 100 mg daily and contained concentrations at least 14-fold higher than plasma. Availability was complete for 200 mg of vitamin C as a single dose. No vitamin C was excreted in urine of 6 of 7 men until the 100-mg dose. At single doses of 500 mg and higher, availability declined and the absorbed amount was excreted. Oxalate and urate excretion were elevated at 1000 mg of vitamin C daily compared to lower doses. Based on these data and Institute of Medicine (USA) criteria, the current RDA of 60 mg daily should be increased to 200 mg daily, which can be obtained from fruits and vegetables. Safe doses of vitamin C are less than 1000 mg daily, and vitamin C daily doses above 400 mg have no evident value.
KW  - ascorbic acid
KW  - estimation
KW  - fruits
KW  - lymphocytes
KW  - monocytes
KW  - neutrophils
KW  - oxalates
KW  - recommended dietary allowances
KW  - uric acid
KW  - vegetables
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - RDA
KW  - recommended dietary intakes
KW  - vegetable crops
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402078&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.
AU  - Lane, M. A.
AU  - Baer, D. J.
AU  - Rumpler, W. V.
AU  - Weindruch, R.
AU  - Ingram, D. K.
AU  - Tilmont, E. M.
AU  - Cutler, R. G.
AU  - Roth, G. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 9
SP  - 4159
EP  - 4164
SN  - 0027-8424
AD  - Lane, M. A.: Molecular Physiology and Genetics Section, Nathan W. Shock Laboratories, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
N1  - Accession Number: 19971412708.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2  - Core (rectal) body temperature decreased progressively with age from 2 to 30 years in rhesus monkeys fed ad libitum (controls) and was reduced by ~0.5°C in age-matched monkeys subjected to 6 years of a 30% reduction in energy intake. A short-term (1 month) 30% restriction of 2.5-year-old monkeys lowered subcutaneous body temperature by 1.0°C. Indirect calorimetry showed that 24-h energy expenditure was reduced by approximately 24% during short-term energy restriction (ER). The temporal association between reduced body temperature and energy expenditure suggests that reductions in body temperature relate to the induction of an energy conservation mechanism during ER. The reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by ER, now strengthening the possibility that ER may exert beneficial effects in primates analogous to those observed in rodents.
KW  - age
KW  - aging
KW  - body temperature
KW  - calorimetry
KW  - energy deprivation
KW  - energy intake
KW  - energy metabolism
KW  - monkeys
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - calorimetric methods
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412708&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.
AU  - Graziosi, C.
AU  - Gantt, K. R.
AU  - Vaccarezza, M.
AU  - Demarest, J. F.
AU  - Daucher, M.
AU  - Saag, M. S.
AU  - Shaw, G. M.
AU  - Quinn, T. C.
AU  - Cohen, O. J.
AU  - Welbon, C. C.
AU  - Pantaleo, G.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 9
SP  - 4386
EP  - 4391
SN  - 0027-8424
AD  - Graziosi, C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1876, USA.
N1  - Accession Number: 19962007611.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref.
KW  - cytokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - interleukins
KW  - kinetics
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007611&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus (HIV) type 2-mediated inhibition of HIV type 1: a new approach to gene therapy of HIV infection.
AU  - Arya, S. K.
AU  - Gallo, R. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 9
SP  - 4486
EP  - 4491
SN  - 0027-8424
AD  - Arya, S. K.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962007614.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref.
KW  - gene therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - susceptibility
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007614&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trafficking of Plasmodium chabaudi adami-infected erythrocytes within the mouse spleen.
AU  - Yadava, A.
AU  - Kumar, S.
AU  - Dvorak, J. A.
AU  - Milon, G.
AU  - Miller, L. H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 10
SP  - 4595
EP  - 4599
SN  - 0027-8424
AD  - Yadava, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970801480.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Protozoology
N2  - It was found that in Plasmodium chabaudi adami infections in mice, crisis (the time of rapidly dropping parasitaemia) was abrogated by splenectomy, indicating the role of spleen in parasite killing. To determine the potential effects of different vascular beds in parasite killing, the distribution of parasitized erythrocytes and bacteria in the spleens of P. chabaudi adami-infected mice was studied during precrisis (a period of rising parasitaemia) and during crisis. After iv injection, bacteria were localized predominantly in the marginal zone. In contrast, parasitized erythrocytes were found in the red pulp. It was also found that during precrisis, a time of no immunity, the uptake of radiolabelled infected erythrocytes by the spleen was increased, not decreased. It is implied that no change occurs in the flow of parasitized erythrocytes through the spleen during the transition to an immune state (crisis). It is suggested that immune effector mechanisms, not circulatory changes, account for spleen-dependent parasite killing during a P. chabaudi adami infection in mice.
KW  - erythrocytes
KW  - experimental infections
KW  - immunity
KW  - laboratory animals
KW  - parasites
KW  - spleen
KW  - mice
KW  - Plasmodium chabaudi
KW  - Plasmodium chabaudi adami
KW  - protozoa
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Plasmodium chabaudi
KW  - blood red cells
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801480&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infectivity of chimeric human T-cell leukemia virus type I molecular clones assessed by naked DNA inoculation.
AU  - Zhao, M.
AU  - Robinson, M. A.
AU  - Bowers, F. S.
AU  - Kindt, T. J.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 13
SP  - 6653
EP  - 6658
SN  - 0027-8424
AD  - Zhao, M.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Facility, National Institutes of Health, Rockville, MD 20852, USA.
N1  - Accession Number: 19972007812.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref.
N2  - Two human T-cell leukemia virus type I (HTLV-I) molecular clones, K30p and K34p were derived from HTLV-I-infected rabbit cell lines. K30p and K34p differ by 18 bp with changes in the long terminal repeats (LTRs) as well as in the gag, pol, and rex but not tax or env gene products. Cells transfected with clone K30p were infectious in vitro and injection of the K30p transfectants or naked K30p DNA into rabbits leads to chronic infection. In contrast, K34p did not mediate infection in vitro or in vivo, although the cell line from which it was derived is fully infectious and K34p transfectants produce intact virus particles. To localize differences involved in the ability of the clones to cause infection, six chimeric HTLV-I clones were constructed by shuffling corresponding fragments containing the substitutions in the LTRs, the gag/pol region and the rex region between K30p and K34p. Cells transfected with any of the six chimeras produced virus, but higher levels of virus were produced by cells transfected with those constructs containing the K30p rex region. Virus production was transient except in cells transfected with K30p or with a chimera consisting of the entire protein coding region of K30p flanked by K34p LTRs; only the transfectants showing persistent virus production mediated in vitro infection. In vivo infection in rabbits following intramuscular DNA injection was mediated by K30p as well as by a chimera of K30p containing the K34p rex gene. Comparisons revealed that virus production was greater and appeared earlier in rabbits injected with K30p. These data suggest that several defects in the K34p clone preclude infectivity and furthermore, provide systems to explore functions of HTLV-I genes.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007812&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro.
AU  - Feng YaXiong
AU  - Copeland, T. D.
AU  - Henderson, L. E.
AU  - Gorelick, R. J.
AU  - Bosche, W. J.
AU  - Levin, J. G.
AU  - Rein, A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 15
SP  - 7577
EP  - 7581
SN  - 0027-8424
AD  - Feng YaXiong: Retroviral Genetics Section, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001061.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 63231-63-0. 
N2  - After a retrovirus particle is released from the cell, the dimeric genomic RNA undergoes a change in conformation. The authors have previously proposed that this change, termed maturation of the dimer, is due to the action of nucleocapsid (NC) protein on the RNA within the virus particle. They now report that treatment of a 345-base synthetic fragment of Harvey sarcoma virus RNA with recombinant or synthetic HIV-1 NC protein converts a less stable form of dimeric RNA to a more stable form. This phenomenon thus appears to reproduce the maturation of dimeric retroviral RNA in a completely defined system in vitro. According to the authors, maturation of dimeric RNA within a retrovirus particle is the first example of action of an "RNA chaperone" protein in vivo. Studies with mutant NC proteins suggest that the activity depends upon basic amino acid residues flanking the N-terminal zinc finger and upon residues within the N-terminal finger, including an aromatic amino acid, but do not require the zinc finger structures themselves.
KW  - amino acids
KW  - HIV-1 infections
KW  - human diseases
KW  - maturation
KW  - nucleocapsid proteins
KW  - proteins
KW  - RNA
KW  - structure
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001061&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cholesterol starvation induces differentiation of the intestinal parasite Giardia lamblia.
AU  - Luján, H. D.
AU  - Mowatt, M. R.
AU  - Byrd, L. G.
AU  - Nash, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 15
SP  - 7628
EP  - 7633
SN  - 0027-8424
AD  - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970800972.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Registry Number: 57-88-5.  Subject Subsets: Protozoology; Tropical Diseases
N2  - The stimulus for cyst formation in Giardia lamblia [G. duodenalis] was investigated. Cyst formation was induced in vitro when trophozoites were starved of cholesterol. Expression of cyst wall proteins was detected within encystation-specific secretory vesicles 90 minutes after the cells were placed in lipoprotein-deficient TYI-S-33 medium. Four cloned lines derived from 2 Giardia isolates were tested, and all formed cysts similarly. Addition of cholesterol, low density or very low density lipoproteins to the lipoprotein-deficient culture medium inhibited the expression of cyst wall proteins, the generation of encystation-specific vesicles and cyst wall biogenesis. In contrast, high density lipoproteins, phospholipids, bile salts and fatty acids had little or no effect. The results indicate that cholesterol starvation is necessary and sufficient for the stimulation of Giardia encystation in vitro and, probably, in the intestine of mammalian hosts.
KW  - cholesterol
KW  - culture media
KW  - development
KW  - developmental stages
KW  - in vitro
KW  - life history
KW  - lipoproteins
KW  - parasites
KW  - proteins
KW  - starvation
KW  - trophozoites
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cysts
KW  - growth phase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800972&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase function.
AU  - Smith, S. M.
AU  - Markham, R. B.
AU  - Jeang KuanTeh
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 15
SP  - 7955
EP  - 7960
SN  - 0027-8424
AD  - Smith, S. M.: Molecular Virology Section. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972001063.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 82410-32-0, 9002-06-6. 
N2  - The development of an effective vaccine for HIV-1 would be a major advance toward controlling the AIDS pandemic. Several disparate strategies for a safe and effective HIV vaccine have been proposed. Recent data suggest that loss-of-function live-attenuated virus could be a safe lentivirus vaccine. The authors propose a gain-of-function approach that can complement loss-of-function in enhancing the safety profile of a live-attenuated virus. An example is described in which ganciclovir (GCV) was used to treat effectively nef(-)HIV-1 engineered to express herpes simplex virus (HSV-1) thymidine kinase (TK). This treatment was found to be highly efficient in controlling HIV-1 spread in tissue culture and in a small animal (hu-PBL-SCID) model.
KW  - animal models
KW  - antiviral agents
KW  - drug therapy
KW  - ganciclovir
KW  - gene therapy
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - mutations
KW  - nef gene
KW  - safety
KW  - thymidine kinase
KW  - vaccines
KW  - Human herpesvirus 1
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - herpes simplex virus 1
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001063&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxoplasma invasion: the parasitophorous vacuole is formed from host cell plasma membrane and pinches off via a fission pore.
AU  - Suss-Toby, E.
AU  - Zimmerberg, J.
AU  - Ward, G. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 16
SP  - 8413
EP  - 8418
SN  - 0027-8424
AD  - Suss-Toby, E.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970800458.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Protozoology
N2  - To test whether the parasitophorous vacuole membrane (PVM) formed by Toxoplasma gondii is derived from host cell membrane or from lipids secreted by the parasite, time-resolved capacitance measurements and video microscopy were used to assay host cell surface area during cell invasion. No significant change was observed in host cell surface area during PVM formation, demonstrating that the PVM consists primarily of invaginated host cell membrane. Pinching-off of the PVM from the host cell membrane occurred after an unexpected delay (34-305 seconds) and was seen as a 0.219 ± 0.006 pF drop in capacitance, which corresponded well to the predicted surface area of the entire PVM (30-33 µm²). The formation and closure of a fission pore connecting the extracellular medium and the vacuolar space was detected as the PVM pinched off. This final stage of parasite invasion was accomplished without any breach in cell membrane integrity.
KW  - cell cultures
KW  - cell invasion
KW  - cell membranes
KW  - host parasite relationships
KW  - microscopy
KW  - parasites
KW  - plasma membranes
KW  - vacuoles
KW  - protozoa
KW  - Toxoplasma gondii
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cell membrane
KW  - parasite host relationships
KW  - parasitophorous vacuole
KW  - plasmalemma
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800458&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
AU  - Silva, A. M.
AU  - Lee, A. Y.
AU  - Gulnik, S. V.
AU  - Majer, P.
AU  - Collins, J.
AU  - Bhat, T. N.
AU  - Collins, P. J.
AU  - Cachau, R. E.
AU  - Luker, K. E.
AU  - Gluzman, I. Y.
AU  - Francis, S. E.
AU  - Oksman, A.
AU  - Goldberg, D. E.
AU  - Erickson, J. W.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 19
SP  - 10034
EP  - 10039
SN  - 0027-8424
AD  - Silva, A. M.: Structural Biochemistry Program, National Cancer Institute/SAIC, P.O. Box B, Frederick, MD 21702, USA.
N1  - Accession Number: 19970805680.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Protozoology
N2  - Plasmodium falciparum encodes 2 homologous aspartic proteases, plasmepsins I and II, which are essential components of its haemoglobin-degradation pathway and are novel targets for antimalarial drug development. The crystal structure of recombinant plasmepsin II complexed with pepstatin A was determined. This represents the first reported crystal structure of a protein from P. falciparum. The crystals contain molecules in 2 different conformations, revealing a remarkable degree of interdomain flexibility of the enzyme. The structure was used to design a series of selective low MW compounds that inhibit both plasmepsin II and the growth of P. falciparum in culture.
KW  - antimalarials
KW  - biochemistry
KW  - crystallography
KW  - drug development
KW  - enzymes
KW  - inhibition
KW  - malaria
KW  - parasites
KW  - proteinases
KW  - structure
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - aspartic proteases
KW  - pepstatin A
KW  - plasmepsin I
KW  - plasmepsin II
KW  - plasmepsins
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805680&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.
AU  - Moss, B.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 21
SP  - 11341
EP  - 11348
SN  - 0027-8424
AD  - Moss, B.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0445, USA.
N1  - Accession Number: 19960106532.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 180 ref. Subject Subsets: Veterinary Science; Agricultural Biotechnology
N2  - The use of vaccinia virus as a vector for expressing genes within the cytoplasm of mammalian cells is reviewed. Recombinant vaccinia viruses are used to synthesize and analyse the structure-function relationship of proteins, determine the targets of humoral and cell-mediated immunity, and investigate the types of immune response needed for protection against specific infectious diseases and cancer. The vaccine potential of recombinant vaccinia virus has been realized in the form of an effective oral wild-life rabies vaccine, although no product for humans has been licensed. A genetically altered vaccinia virus that is unable to replicate in mammalian cells and produces diminished cytopathic effects retains the capacity for high-level gene expression and immunogenicity while promising exceptional safety for laboratory workers and potential vaccine recipients.
KW  - biotechnology
KW  - gene expression
KW  - recombinant vaccines
KW  - reviews
KW  - safety
KW  - vaccination
KW  - vectors
KW  - vaccinia virus
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960106532&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of circumsporozoite proteins from avian and mammalian malarias: biological and phylogenetic implications.
AU  - McCutchan, T. F.
AU  - Kissinger, J. C.
AU  - Touray, M. G.
AU  - Rogers, M. J.
AU  - Li Jun
AU  - Sullivan, M.
AU  - Braga, E. M.
AU  - Krettli, A. U.
AU  - Miller, L. H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 21
SP  - 11889
EP  - 11894
SN  - 0027-8424
AD  - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970800371.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Circumsporozoite (CS) protein genes have been characterized from many Plasmodium that infect mammals: 2 domains of the corresponding proteins, identified initially by their conservation (region I and region II), have been implicated in binding to hepatocytes. The CS gene from the avian parasite Plasmodium gallinaceum was characterized to compare these functional domains to those of mammalian Plasmodium and for the study of Plasmodium evolution. The P. gallinaceum protein showed the characteristics of CS proteins, including a secretory signal sequence, central repeat region, regions of charged amino acids and an anchor sequence. Comparison with CS signal sequences revealed 4 distinct groupings, with P. gallinaceum most closely related to the human P. falciparum. The 5-amino acid sequence designated region I, which is identical in all mammalian CS and implicated in hepatocyte invasion, was different in P. gallinaceum where the repeat region consists of 9-amino acid repeats with the consensus sequence QP(A/V)GGNGG(A/V). The conserved motif designated region II-plus, which is associated with targeting the invasion of liver cells, was also conserved in P. gallinaceum. Phylogenetic analysis of the aligned Plasmodium CS sequences yielded a tree with a topology similar to the one obtained using sequence data from the small subunit rRNA gene. The phylogeny using the CS gene supports the proposal that P. falciparum is significantly more related to avian Plasmodium than to other Plasmodium infecting mammals, although the biology of sporozoite invasion is different between the avian and mammalian species.
KW  - amino acid sequences
KW  - characterization
KW  - circumsporozoite protein
KW  - evolution
KW  - genes
KW  - liver cells
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - phylogeny
KW  - proteins
KW  - sporozoites
KW  - surface proteins
KW  - birds
KW  - mammals
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Plasmodium
KW  - biochemical genetics
KW  - DNA sequences
KW  - hepatocytes
KW  - membrane proteins
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800371&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity.
AU  - Zheng, R.
AU  - Jenkins, T. M.
AU  - Craigie, R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 24
SP  - 13659
EP  - 13664
SN  - 0027-8424
AD  - Zheng, R.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0560, USA.
N1  - Accession Number: 19972004868.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 7440-66-6. 
N2  - Studies of the binding of zinc to HIV-1 integrase protein showed that it bound zinc with a stoichiometry of 1 zinc per integrase monomer. Analysis of zinc binding to deletion derivatives of integrase located the binding site to the N-terminal domain. Integrase with a mutation in the pair of His and Cys residues (HHCC motif) did not bind zinc, consistent with coordination of zinc by these residues. The isolated N-terminal domain was disordered in the absence of zinc but, in the presence of zinc, it adopted a secondary structure with a high alpha helical content. Integrase bound by zinc tetramerized more readily than the apoenzyme and was also more active than the apoenzyme in in vitro integration assays. It is concluded that binding of zinc to the HHCC motif stabilizes the folded state of the N-terminal domain of integrase and bound zinc is required for optimal enzymatic activity.
KW  - catalytic activity
KW  - derivatives
KW  - enzymes
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - mutations
KW  - residues
KW  - structure
KW  - zinc
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004868&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines.
AU  - Kinter, A. L.
AU  - Ostrowski, M.
AU  - Goletti, D.
AU  - Oliva, A.
AU  - Weissman, D.
AU  - Gantt, K.
AU  - Hardy, E.
AU  - Jackson, R.
AU  - Ehler, L.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 24
SP  - 14076
EP  - 14081
SN  - 0027-8424
AD  - Kinter, A. L.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1576, USA.
N1  - Accession Number: 19972004866.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 308079-78-9. 
N2  - This study demonstrates that the β-chemokines macrophage inflammatory proteins 1α and 1β (MIP-1α and MIP-1β) and RANTES (regulated on activation, normally T-cell expressed and secreted) inhibit HIV replication in anti-CD3 or recall antigen-stimulated peripheral blood mononuclear cells (PBMC) of asymptomatic HIV-infected subjects. Significant levels of β-chemokines were produced by both CD4+ and CD8+ PBMC subsets from HIV-infected individuals. Neutralization of endogenous MIP-1α, MIP-1β and RANTES did not rescue HIV replication in cultures to which &gt;10% CD8+ T cells had been added, indicating that the HIV suppressor activity of CD8+ T cells cannot be explained entirely by the β-chemokines. However, significant enhancement of viral replication was observed upon neutralization of endogenous β-chemokines in CD8-depleted or CD4+ PBMCs from most donors, particularly in cultures with low inducible levels of HIV production. In contrast, certain endogenous proinflammatory cytokines induced HIV replication in these same cells. It is suggested that the levels of HIV replication in CD4+ PBMC reflect the balance of the opposing effects of endogenous suppressive factors, such as the β-chemokines, and HIV-inducing cytokines, such as tumour necrosis factor-α and interleukin 1β.
KW  - asymptomatic infections
KW  - chemokines
KW  - cytokines
KW  - effects
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interleukins
KW  - macrophages
KW  - neutralization
KW  - proteins
KW  - regulation
KW  - replication
KW  - t lymphocytes
KW  - tumour necrosis factor
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cachectin
KW  - cachexin
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004866&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transduction of nondividing cells using pseudotyped defective high-titre HIV type 1 particles.
AU  - Reiser, J.
AU  - Harmison, G.
AU  - Kluepfel-Stahl, S.
AU  - Brady, R. O.
AU  - Karlsson, S.
AU  - Schubert, M.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 26
SP  - 15266
EP  - 15271
SN  - 0027-8424
AD  - Reiser, J.: Molecular and Medical Genetics Section, Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001394.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
N2  - Pseudotyped HIV-1 particles carrying either the ecotropic or amphotropic Moloney murine leukaemia virus (Mo-MLV) envelope proteins or the vesicular stomatitis virus G protein were released after single or double transfections of either human 293T or monkey COS-7 cells with titres of up to 107 colony-forming units/ml. A simple ultrafiltration procedure resulted in an additional 10 to 20-fold concentration of the pseudotyped particles. These vectors along with Mo-MLV-based vectors were used to transduce primary human skin fibroblasts and human peripheral blood CD34+ cells. The HIV-1 vector system was significantly more efficient than its Mo-MLV-based counterpart in transducing human skin fibroblasts arrested at the G0/G1 stage of the cell cycle by density-dependent inhibition of growth. Human CD34+ cells were transduced efficiently using HIV-1 pseudotype particles without prior stimulation with cytokines.
KW  - disease vectors
KW  - envelope proteins
KW  - fibroblasts
KW  - gene therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - proteins
KW  - stimulation
KW  - treatment
KW  - vectors
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CD8+ T-cell-derived soluble factor(s), but not β-chemokines RANTES, MIP-1α, and MIP-1β, suppress HIV-1 replication in monocyte/macrophages.
AU  - Moriuchi, H.
AU  - Moriuchi, M.
AU  - Combadiere, C.
AU  - Murphy, P. M.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1996///
VL  - 93
IS  - 26
SP  - 15341
EP  - 15345
SN  - 0027-8424
AD  - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001397.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 9008-11-1. 
N2  - To investigate whether a CD8+ T-cell-derived soluble factor(s) can also suppress HIV infection in the monocyte/macrophage (M/M) system, primary macrophages were infected with the macrophage tropic HIV-1 strain Ba-L. CD8+ T-cell-depleted peripheral blood mononuclear cells were also infected with HIV-1 IIIB or Ba-L. HIV expression from the chronically infected macrophage cell line U1 was also determined in the presence of CD8+ T-cell supernatants or β-chemokines. It is demonstrated that: CD8+ T-cell supernatants did, but β-chemokines did not, suppress HIV replication in the M/M system; antibodies to RANTES (regulated on activation normal T-cell expressed and secreted), macrophage inflammatory protein 1α (MIP-1α) and MIP-1β did not, whereas antibodies to interleukin-10, interleukin-13, interferon-α or interferon-γ modestly reduced anti-HIV activity of the CD8+ T-cell supernatants; and the CD8+ T-cell supernatants did, but β-chemokines did not, suppress HIV-1 IIIB replication in peripheral blood mononuclear cells as well as HIV expression in U1 cells. It is suggested that HIV-suppressor activity of CD8+ T cells is a multifactorial phenomenon, and that RANTES, MIP-1α and MIP-1β do not account for the entire scope of CD8+ T-cell-derived HIV-suppressor factors.
KW  - antibodies
KW  - antigens
KW  - cd8 antigens
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - interferon
KW  - macrophages
KW  - replication
KW  - t lymphocytes
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - antigenicity
KW  - CD8
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001397&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Modulation of T cell responses to recall antigens presented by Langerhans cells in HIV-discordant identical twins by anti-interleukin (IL)-10 antibodies and IL-12.
AU  - Blauvelt, A.
AU  - Chougnet, C.
AU  - Shearer, G. M.
AU  - Katz, S. I.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1996///
VL  - 97
IS  - 6
SP  - 1550
EP  - 1555
SN  - 0021-9738
AD  - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19962006259.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref.
KW  - cytokines
KW  - dendritic cells
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - interleukins
KW  - T lymphocytes
KW  - twins
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Langerhans cells
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006259&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pain in pediatric human immunodeficiency virus infection: incidence and characteristics in a single-institution pilot study.
AU  - Hirschfeld, S.
AU  - Moss, H.
AU  - Dragisic, K.
AU  - Smith, W.
AU  - Pizzo, P. A.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1996///
VL  - 98
IS  - 3
SP  - 449
EP  - 452
SN  - 0031-4005
AD  - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
N1  - Accession Number: 19982002082.  Publication Type: Journal Article; Annual report; Journal article.  Language: English. 
N2  - Children with human immunodeficiency virus (HIV) infection have multiple complications associated with the disease process. Many of these complications are potentially painful and could affect the patient's quality of life. We examined the incidence and characteristics of the perception of pain in a cohort of families with children with HIV infection. A questionnaire was developed and validated with a cohort of families with children with cancer. In a survey of families at the Pediatric Branch of the National Cancer Institute, 61 children with HIV infection and their care givers, along with 19 children with cancer and their care givers, were interviewed to determine the incidence and impact of pain. Fifty-nine percent of the HIV-infected children and 55% of their care givers described pain as a component of their illness that impacted on their lives. Younger children and girls tended to report more pain. There was also a tendency for biological parents to expect and to treat more pain than foster parents, although there was no difference in the incidence of pain that biological and foster parents reported for their children. No differences were found between parents who were HIV positive and those who were not. In addition, no correlations were noted in incidence, expectation, or impact of pain with disease progression or surrogate markers such as CD4 counts. Pain in HIV-infected patients tended to be either in the gastrointestinal tract or limbs and usually responded to nonsteroidal anti-inflammatory therapy. The patients with cancer reported an incidence (47%) and impact of pain similar to those of previously reported studies on pediatric patients with cancer. Pain is common among children infected with HIV and can adversely impact on their lives, and its management should be a component of the general care of these patients.
KW  - CD4 antigens
KW  - children
KW  - complications
KW  - digestive system
KW  - digestive tract
KW  - disease course
KW  - families
KW  - girls
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - illness
KW  - infection
KW  - management
KW  - neoplasms
KW  - patients
KW  - questionnaires
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - alimentary tract
KW  - cancers
KW  - care providers
KW  - CD4
KW  - disease progression
KW  - gastrointestinal system
KW  - gastrointestinal tract
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - perceptions
KW  - Health Services (UU350) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002082&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV infection-induced posttranslational modification of T cell signaling molecules associated with disease progression.
AU  - Štefanová, I.
AU  - Saville, M. W.
AU  - Peters, C.
AU  - Cleghorn, F. R.
AU  - Schwartz, D.
AU  - Venzon, D. J.
AU  - Weinhold, K. J.
AU  - Jack, N.
AU  - Bartholomew, C.
AU  - Blattner, W. A.
AU  - Yarchoan, R.
AU  - Bolen, J. B.
AU  - Horak, I. D.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1996///
VL  - 98
IS  - 6
SP  - 1290
EP  - 1297
SN  - 0021-9738
AD  - Štefanová, I.: Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001029.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
N2  - In order to elucidate the mechanism of the HIV infection induced T cell unresponsiveness, signal-transducing molecules proximal to the T cell receptor (TCR) were studied in T lymphocytes of HIV-infected individuals. Total amounts of protein tyrosine kinases (PTKs) Lck, Fyn and ZAP-70 and the ζ chain of the TCR were found significantly decreased in T cells of symptomatic/AIDS patients as well as in T cells of individuals in acute and early asymptomatic stages of HIV infection. Unexpectedly, the detection of Lck, Fyn and ZAP-70 was reversed after the treatment of cell lysates with dithiothreitol. It is suggested that PTKs Lck, Fyn and ZAP-70 are modified by a mechanism altering the status of sulfhydryl groups. Moreover, this mechanism seemed to affect selectively T cells of HIV infected patients since B cell PTKs Syk and Lyn were detected structurally and functionally intact. Similar alterations of signalling molecules were not detected in T cells of HIV-infected long-term asymptomatic individuals. It is suggested that modification of T cell PTKs may therefore underlie the HIV-induced impairment of lymphocyte function and may potentially predict disease progression.
KW  - acquired immune deficiency syndrome
KW  - disease course
KW  - enzymes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - receptors
KW  - signal transduction
KW  - t lymphocytes
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - disease progression
KW  - human immunodeficiency virus
KW  - protein tyrosine kinases
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001029&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fungal infections. A growing threat.
AU  - Dixon, D. M.
AU  - McNeil, M. M.
AU  - Cohen, M. L.
AU  - Gellin, B. G.
AU  - Montagne, J. R. la
JO  - Public Health Reports
JF  - Public Health Reports
Y1  - 1996///
VL  - 111
IS  - 3
SP  - 226
EP  - 235
SN  - 0033-3549
AD  - Dixon, D. M.: Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19961201440.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The emergence of newly identified fungal pathogens and the re-emergence of previously uncommon fungal diseases in immunocompromised patients are reviewed. Infections due to Pneumocystis carinii, Candida, Cryptococcus neoformans, Trichosporon, Malassezia, Aspergillus, Penicillium marneffei, Coccidioides immitis, Histoplasma capsulatum, Blastomyces dermatitidis and Sporothrix schenckii are considered. The prevention and control of these mycoses is discussed, including increased surveillance, availability of rapid, non-invasive diagnostic tests and monitoring the development of resistance to antifungal agents.
KW  - aspergillosis
KW  - blastomycosis
KW  - candidosis
KW  - coccidioidomycosis
KW  - control
KW  - cryptococcosis
KW  - diagnosis
KW  - drug resistance
KW  - drug therapy
KW  - histoplasmosis
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunosuppression
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - pneumocystosis
KW  - predisposition
KW  - reviews
KW  - sporotrichosis
KW  - Aspergillus
KW  - Blastomyces dermatitidis
KW  - Candida
KW  - Coccidioides immitis
KW  - Cryptococcus neoformans
KW  - Histoplasma capsulatum
KW  - Malassezia
KW  - man
KW  - Penicillium marneffei
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Sporothrix schenckii
KW  - Trichosporon
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Blastomyces
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Coccidioides
KW  - Onygenaceae
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Malasseziales
KW  - Ustilaginomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Penicillium
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Sporothrix
KW  - Ophiostomataceae
KW  - Ophiostomatales
KW  - Sordariomycetes
KW  - Trichosporonaceae
KW  - Ajellomyces capsulatus
KW  - candidiasis
KW  - chemotherapy
KW  - coccidiomycosis
KW  - european blastomycosis
KW  - fungus
KW  - Hyphomycetes
KW  - penicilliosis
KW  - trichosporonosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201440&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inclusion body myositis in HIV-1 and HTLV-1 infected patients.
AU  - Cupler, E. J.
AU  - Leon-Monzon, M.
AU  - Miller, J.
AU  - Semino-Mora, C.
AU  - Anderson, T. L.
AU  - Dalakas, M. C.
JO  - Brain
JF  - Brain
Y1  - 1996///
VL  - 119
SP  - 1887
EP  - 1893
AD  - Cupler, E. J.: The Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, Building 10, Rm 4N248, MSC 1382, Bethesda, MD 20892-1382, USA.
N1  - Accession Number: 19972002850.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref.
N2  - Three retrovirally infected patients are described, two with HIV-1 and one with HTLV-I, with clinical, immunopathological and histological features identical to sporadic inclusion body myositis occurring in non-infected patients.
KW  - body parts
KW  - case reports
KW  - clinical aspects
KW  - histology
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - musculoskeletal system
KW  - pathology
KW  - USA
KW  - Deltaretrovirus
KW  - Human immunodeficiency virus 1
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - clinical picture
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - skeletomuscular system
KW  - sporadic infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002850&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Advances in the management of AIDS-related cytomegalovirus retinitis.
AU  - Masur, H.
AU  - Whitcup, S. M.
AU  - Cartwright, C.
AU  - Polis, M.
AU  - Nussenblatt, R.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1996///
VL  - 125
IS  - 2
SP  - 126
EP  - 136
SN  - 0003-4819
AD  - Masur, H.: Clinical Center of the National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19962007270.  Publication Type: Journal Article.  Language: English.  Number of References: 69 ref.
KW  - acquired immune deficiency syndrome
KW  - clinical aspects
KW  - drug therapy
KW  - eye diseases
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - medical treatment
KW  - prophylaxis
KW  - retinitis
KW  - reviews
KW  - cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relation between sodium balance and menstrual cycle symptoms in normal women.
AU  - Olson, B. R.
AU  - Forman, M. R.
AU  - Lanza, E.
AU  - McAdam, P. A.
AU  - Beecher, G.
AU  - Kimzey, L. M.
AU  - Campbell, W. S.
AU  - Raymond, E. G.
AU  - Brentzel, S. L.
AU  - Guttsches-Ebeling, B.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1996///
VL  - 125
IS  - 7
SP  - 564
EP  - 567
SN  - 0003-4819
AD  - Olson, B. R.: National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19971402940.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9015-94-5, 7440-23-5.  Subject Subsets: Human Nutrition
N2  - A prospective study of menstrual symptoms during 3 cycles: a baseline month (usual intake of sodium 115 mmol/day) followed by 2 months of Na restriction (Na intake 73.0 mmol/day) was undertaken in 13 healthy menstruating women (21-35 years old). Added salt was allowed during the last month. Investigators were aware of the diet sequence. Meals were prepared in a metabolic kitchen during the 2 months that the participants received salt-restricted diets. Plasma Na levels, urinary Na excretion and plasma renin activity were measured for 5 time periods during the baseline cycle and the 2 cycles of salt-restricted diet. 11 women completed a questionnaire assessing somatic symptoms and sensory cravings at the same time every day during the 3-month study period. Na restriction was associated with a mean decrease in plasma Na levels of 0.9±0.9 mmol/litre from a mean of 139.3 mmol/litre during the baseline cycle (P=0.018), a decrease in urinary Na excretion of 40.3±18 mmol/day from a mean of 117 mmol/day during the baseline cycle (P=0.001) and an increase in plasma renin activity of 0.14±0.08 ng/(litre/s) from a mean of 0.28 ng/(litre/s) during the baseline cycle (P=0.008). During the luteal phase of the Na restriction cycle, significant decreases in plasma Na levels of 1.23±0.5 mmol/litre (from values of 138.8 mmol/litre during the follicular phase) and increases in urinary Na excretion of 27.2±10 mmol/day (from values of 65.5 mmol/day during the follicular phase) preceded periods when menstrual symptoms were most severe. Ratings of breast tenderness increased 6- to 8-fold in the late luteal phase (P&lt;0.001) and those of swelling or bloating increased 2- to 3-fold during early menses (P&lt;0.001) compared with nadir symptom ratings during each cycle. Na cravings increased in the luteal phase of all cycles but were not accompanied by increased Na intake when access to added salt was allowed. Breast tenderness and bloating did not result from sodium retention in the luteal phase of the menstrual cycle. During normal and Na-restricted diet cycles, women actually had urinary Na loss, not retention, during the luteal phase; severity of menstrual symptoms was unchanged.
KW  - activity
KW  - blood
KW  - deprivation
KW  - excretion
KW  - intake
KW  - menstrual cycle
KW  - menstruation
KW  - minerals
KW  - renin
KW  - salt
KW  - sodium
KW  - symptoms
KW  - urine
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human Reproduction and Development (VV060) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402940&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analytical instruments for stable isotopic tracers in mineral metabolism.
AU  - Yergey, A. L.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 1
SP  - 355S
EP  - 361S
SN  - 0022-3166
AD  - Yergey, A. L.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961402398.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Registry Number: 7440-70-2, 7439-89-6, 7439-95-4, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - Thermal ionization mass spectrometry (TIMS) is the best of 4 currently used techniques for obtaining results of high accuracy and precision in studies of metal metabolism. TIMS is also the most general technique because it allows measurements of all the metallic elements of interest. The highest absolute sensitivity as well as the ability to determine multiple elements are simultaneously obtained with inductively coupled plasma mass spectrometry (ICP-MS). Current results with this technique show that, although element quantification may be done with acceptable accuracy and precision, use of ICP-MS in metabolic studies at low levels of isotopic labels may be limited. The most favourable elements for study using ICP-MS in metabolic studies appear to be magnesium, zinc and possibly iron. Use of this technique is limited further by isobaric interferences from plasma jet ion molecule reactions, and metabolic studies of calcium are particularly limited. Acceptable levels of accuracy and precision have been obtained from fast atom bombardment-secondary ion mass spectrometry (FAB-SIMS), which has allowed these approaches to be used in metabolic studies of Zn, Fe and Ca, but the approaches are ultimately limited by hydride isobaric interferences. FAB-SIMS and gas chromatography-mass spectrometry of metal chelates have the advantages of using widely available instrumentation. GC-MS of metal chelates has been shown to be useful in studies of chromium and selenium metabolism and for the determination of a number of other metals. Values of accuracy and precision from use of this approach have been satisfactory.
KW  - analytical methods
KW  - calcium
KW  - iron
KW  - magnesium
KW  - metabolism
KW  - mineral metabolism
KW  - trace elements
KW  - tracer techniques
KW  - zinc
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - microelements
KW  - Techniques and Methodology (ZZ900) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402398&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Homocysteine and neural tube defects.
AU  - Mills, J. L.
AU  - Scott, J. M.
AU  - Kirke, P. N.
AU  - McPartlin, J. M.
AU  - Conley, M. R.
AU  - Weir, D. G.
AU  - Molloy, A. M.
AU  - Lee, Y. J.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 3
SP  - 756S
EP  - 760S
SN  - 0022-3166
AD  - Mills, J. L.: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20893, USA.
N1  - Accession Number: 19961404260.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 59-30-3, 6027-13-0.  Subject Subsets: Human Nutrition
N2  - Homocysteine and neural tube defects (NTD) are reviewed under the headings: Is folate deficiency the cause of NTDs?; Is abnormal folate absorption the cause of NTDs?; Is a metabolic abnormality the cause of NTDs?; Is vitamin B12 a factor in NTDs?; Homocysteine levels in affected pregnancies; Animal studies of homocysteine metabolism in NTDs; and Other data suggesting that homocysteine metabolism is important.
KW  - congenital abnormalities
KW  - folic acid
KW  - homocysteine
KW  - nervous system diseases
KW  - pregnancy
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - birth defects
KW  - congenital malformations
KW  - folacin
KW  - folate
KW  - gestation
KW  - neuropathy
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404260&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary intake of fat, fiber and other nutrients is related to the use of vitamin and mineral supplements in the United States: the 1992 National Health Interview Survey.
AU  - Slesinski, M. J.
AU  - Subar, A. F.
AU  - Kahle, L. L.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 12
SP  - 3001
EP  - 3008
SN  - 0022-3166
AD  - Slesinski, M. J.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971403658.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 68-26-8, 1406-18-4, 50-81-7, 7440-70-2.  Subject Subsets: Human Nutrition
N2  - Nutrient intake from a food frequency questionnaire, demographic characteristics and lifestyle were examined in 11 643 dietary supplement users and non-users who participated in the 1992 National Health Interview Survey Epidemiology Supplement, USA. 46% reported taking a supplement in the past year, while 24% reported daily use. Daily use was highest among women, whites, people ≥75 years old, those at or above the poverty level, those with more than 12 years of education, former smokers and light drinkers consuming &lt;1 alcoholic beverage per week. When sociodemographic factors, smoking status and drinking habits were controlled for, there were no significant differences in dietary nutrient intake between daily and occasional supplement users. Compared with those of non-users, diets of vitamin supplement users were lower (P&lt;0.001) in fat and higher in fibre and vitamins A and C for men and women and higher in vitamin E and calcium for women only. It was concluded that the diet and the demographic and lifestyle characteristics of supplement users are typical of patterns associated with low risk of chronic disease.
KW  - age
KW  - alcoholic beverages
KW  - ascorbic acid
KW  - calcium
KW  - consumption
KW  - diet
KW  - diet studies
KW  - education
KW  - ethnicity
KW  - fat
KW  - fibre
KW  - health
KW  - intake
KW  - lifestyle
KW  - men
KW  - mineral supplements
KW  - minerals
KW  - mortality
KW  - neoplasms
KW  - nutrients
KW  - retinol
KW  - sex differences
KW  - socioeconomic status
KW  - tobacco smoking
KW  - vitamin e
KW  - vitamin supplements
KW  - vitamins
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - cancers
KW  - death rate
KW  - ethnic differences
KW  - fiber
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403658&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Overview of perinatal HIV infection.
AU  - Fowler, M. G.
AU  - Rogers, M. F.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 10SUPPL
SP  - 2602S
EP  - 2607S
SN  - 0022-3166
AD  - Fowler, M. G.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.
N1  - Accession Number: 19971400212.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 51 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - An overview of the epidemiology of perinatal human immunodeficiency virus infection internationally is given, summarizing research on risk factors for mother-to-infant transmission. Perinatal prevention strategies being planned in developing and developed countries are discussed.
KW  - breast feeding
KW  - epidemiology
KW  - human immunodeficiency viruses
KW  - infants
KW  - infection
KW  - mothers
KW  - parturition
KW  - pregnancy
KW  - prevention
KW  - reviews
KW  - risk factors
KW  - transmammary transmission
KW  - transmission
KW  - transplacental transmission
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gestation
KW  - human immunodeficiency virus
KW  - Nutrition in pediatric HIV infection:setting the research agenda
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400212&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dysregulation of growth and development in HIV-infected children.
AU  - Hirschfeld, S.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 10SUPPL
SP  - 2641S
EP  - 2650S
SN  - 0022-3166
AD  - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971400242.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 25 ref. Registry Number: 61912-98-9, 9002-72-6, 9034-48-4.  Subject Subsets: Human Nutrition
N2  - Data from studies on growth stunting in infants and children infected with the human immunodeficiency virus and interactions between HIV and factors involved in the cellular regulation of growth are reviewed.
KW  - children
KW  - development
KW  - dysregulation
KW  - growth
KW  - growth retardation
KW  - human immunodeficiency viruses
KW  - infants
KW  - insulin-like growth factor
KW  - lymphocytes
KW  - metabolism
KW  - reviews
KW  - somatotropin
KW  - thyrotropin
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - growth hormone
KW  - human immunodeficiency virus
KW  - Nutrition in pediatric HIV infection:setting the research agenda
KW  - somatomedin C
KW  - thyroid-stimulating hormone
KW  - thyrotropic hormone
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400242&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neurobehavioral manifestations of symptomatic HIV-1 disease in children: can nutritional factors play a role?
AU  - Brouwers, P.
AU  - Decarli, C.
AU  - Heyes, M. P.
AU  - Moss, H. A.
AU  - Wolters, P. L.
AU  - Tudor-Williams, G.
AU  - Civitello, L. A.
AU  - Pizzo, P. A.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 10SUPPL
SP  - 2651S
EP  - 2662S
SN  - 0022-3166
AD  - Brouwers, P.: Pediatric Branch, National Cancer Institute, NIH Clinical Cancer, Room 13N240, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19971400210.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 65 ref. Registry Number: 16887-00-6, 68-19-9, 59-30-3, 65-23-6, 30516-87-1.  Subject Subsets: Human Nutrition
N2  - This paper reviews studies investigating the influence of nutrition on the psychological function of children, in the context of human immunodeficiency virus (HIV) infection. Also the findings of a study by the authors are presented, which evaluated the association of change in body weight with changes in neurocognitive function, ventricular brain ratio and cerebrospinal quinolinic acid levels in HIV infected children (n=15; mean age 6.3 years) with symptomatic HIV-1 disease before and after 6 months of antiretroviral therapy with continuous intravenous infusion of zidovudine (ZVD). Significant increases in weight and neurocognitive function as well as decreases in ventricular brain ratio and cerebrospinal quinolinic acid levels were noted after therapy. Only the relation between increase in weight and decrease in ventricular brain ratio was significant (P&lt;0.01); an increase in weight seemed to correlate with a decrease in neurocognitive function (NS). Another group of children treated at the same time with oral intermittent ZVD, but otherwise receiving the same care did not show the same magnitude of improvement in neurocognitive function. These results seem to suggest that general supportive and medical care as well as nutritional factors may only play a limited role in the neurocognitive improvements after antiretroviral therapy with continuous infusion ZVD.
KW  - antiviral agents
KW  - brain
KW  - cerebrospinal fluid
KW  - children
KW  - chloride
KW  - cognitive development
KW  - cyanocobalamin
KW  - deficiency
KW  - drug therapy
KW  - encephalopathy
KW  - folic acid
KW  - human immunodeficiency viruses
KW  - infection
KW  - malnutrition
KW  - neurochemistry
KW  - protein energy malnutrition
KW  - psychology
KW  - pyridoxine
KW  - trace elements
KW  - vitamin b12
KW  - vitamins
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - cerebrum
KW  - chemotherapy
KW  - cobalamin
KW  - folacin
KW  - folate
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - mental development
KW  - microelements
KW  - Nutrition in pediatric HIV infection:setting the research agenda
KW  - protein calorie malnutrition
KW  - psychological factors
KW  - Physiology of Human Nutrition (VV120) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400210&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intakes of minerals from diets and foods: is there a need for concern?
AU  - Pennington, J. A. T.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996///
VL  - 126
IS  - 9SUPPL
SP  - 2304S
EP  - 2308S
SN  - 0022-3166
AD  - Pennington, J. A. T.: Division of Nutrition Research Coordination, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda MD 20892-6600, USA.
N1  - Accession Number: 19961410081.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 15 ref. Registry Number: 7440-70-2, 7440-50-8, 7553-56-2, 7439-89-6, 7439-95-4, 7439-96-5, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - This paper reviews results of the Total Diet Study, a yearly programme of the Food and Drug Administration in the USA, which as part of its monitoring of food supply, identifies changes and trends in the mineral content of foods and estimates daily mineral intakes. Results of the Total Diet Study are compared with results from other studies and it is concluded that there is a need for concern about intakes of calcium, magnesium, iron, zinc and copper for some age-sex categories in the USA.
KW  - calcium
KW  - copper
KW  - diet studies
KW  - iodine
KW  - iron
KW  - magnesium
KW  - manganese
KW  - minerals
KW  - nutrient requirements
KW  - phosphorus
KW  - potassium
KW  - salt
KW  - selenium
KW  - sodium
KW  - trace elements
KW  - zinc
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - dietary standards
KW  - food requirements
KW  - microelements
KW  - Mn
KW  - New approaches, endpoints and paradigms for RDAs of mineral elements
KW  - nutritional requirements
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410081&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Natural history of somatic growth in infants born to women infected by human immunodeficiency virus.
AU  - Moye, J., Jr.
AU  - Rich, K. C.
AU  - Kalish, L. A.
AU  - Sheon, A. R.
AU  - Diaz, C.
AU  - Cooper, E. R.
AU  - Pitt, J.
AU  - Handelsman, E.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1996///
VL  - 128
IS  - 1
SP  - 58
EP  - 69
SN  - 0022-3476
AD  - Moye, J., Jr.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
N1  - Accession Number: 19962003776.  Publication Type: Journal Article.  Corporate Author: USA, Women and Infants Transmission Study Group Language: English. 
KW  - acquired immune deficiency syndrome
KW  - anthropometric dimensions
KW  - growth
KW  - growth factors
KW  - height
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - natural history
KW  - weight
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - anthropometric measurements
KW  - head dimensions (agricola)
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - maternal
KW  - women transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003776&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Thyroid abnormalities in children infected with human immunodeficiency virus.
AU  - Hirschfeld, S.
AU  - Laue, L.
AU  - Cutler, G. B., Jr.
AU  - Pizzo, P. A.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1996///
VL  - 128
IS  - 1
SP  - 70
EP  - 74
SN  - 0022-3476
AD  - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19962003777.  Publication Type: Journal Article.  Language: English.  Registry Number: 51-48-9, 55-06-1, 6893-02-3. 
KW  - abnormalities
KW  - acquired immune deficiency syndrome
KW  - children
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - T lymphocytes
KW  - thyroid gland
KW  - thyroid hormones
KW  - thyroxine
KW  - triiodothyronine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - function
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - liothyronine
KW  - T cells
KW  - thyroid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003777&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of virus burden in blood and sequential lymph node biopsy specimens from children infected with human immunodeficiency virus.
AU  - Mueller, B. U.
AU  - Sei, S.
AU  - Anderson, B.
AU  - Luzuriaga, K.
AU  - Farley, M.
AU  - Venzon, D. J.
AU  - Tudor-Williams, G.
AU  - Schwartzentruber, D. J.
AU  - Fox, C.
AU  - Sullivan, J. L.
AU  - Pizzo, P. A.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1996///
VL  - 129
IS  - 3
SP  - 410
EP  - 418
SN  - 0022-3476
AD  - Mueller, B. U.: Pediatric Branch, National Cancer Institute, Bethesda MD 20892-1928, USA.
N1  - Accession Number: 19962009319.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 129618-40-2. 
KW  - antiviral agents
KW  - biopsy
KW  - children
KW  - disease course
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymph nodes
KW  - nevirapine
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009319&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of a unique VP4 serotype that is shared by a human rotavirus (69M strain) and an equine rotavirus (H-2 strain).
AU  - Li, B.
AU  - Hoshino, Y.
AU  - Gorziglia, M.
JO  - Archives of Virology
JF  - Archives of Virology
Y1  - 1996///
VL  - 141
IS  - 1
SP  - 155
EP  - 160
SN  - 0304-8608
AD  - Li, B.: Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19962215624.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - A cDNA clone representing the VP4-encoding gene of human rotavirus strain 69M (VP7 serotype 8) was constructed and inserted into a baculovirus expression vector. Baculovirus recombinants that expressed the 69M VP4 protein in Spodoptera frugiperda (Sf9) cells were screened by immunofluoresence with hyperimmune antiserum to the 69M strain and purified by terminal dilution. The expressed VP4 was detected by Coomassie blue staining of PAGE-separated proteins. The antigenic relationships between the VP4 of the 69M strain and those of various human and other animal rotavirus strains representing 10 established VP4 serotypes were examined by plaque reduction neutralization. Hyperimmune antiserum produced in guineapigs following immunization with a lysate of Sf9 cells infected with a 69M gene-4-baculovirus recombinant neutralized the infectivity of the homologous human rotavirus 69M strain as well as heterologous equine rotavirus H-2 strain to a high titre. The anti-69M VP4 hyperimmune antiserum did not neutralize other rotavirus strains of human, simian, porcine, bovine, or murine origin. It is concluded that the human rotavirus 69M strain has a distinct VP4 serotype (designated as P serotype 4) which is closely related antigenically to equine rotavirus H-2 VP4.
KW  - antigenic variation
KW  - gene expression
KW  - horse diseases
KW  - immune serum
KW  - infectivity
KW  - recombination
KW  - serotypes
KW  - viral diseases
KW  - viral proteins
KW  - virus neutralization
KW  - horses
KW  - man
KW  - rotavirus
KW  - Equus
KW  - Equidae
KW  - Perissodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - antigenic polymorphism
KW  - antiserum
KW  - genetic recombination
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pets and Companion Animals (LL070) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States.
AU  - Song, J. W.
AU  - Baek, L. J.
AU  - Nagle, J. W.
AU  - Schlitter, D.
AU  - Yanagihara, R.
JO  - Archives of Virology
JF  - Archives of Virology
Y1  - 1996///
VL  - 141
IS  - 5
SP  - 959
EP  - 967
SN  - 0304-8608
AD  - Song, J. W.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19970500579.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 63231-63-0. 
N2  - The S and M segments of a hantavirus, enzymatically amplified from tissues of Cloudland deer mice (Peromyscus maniculatus nubiterrae) captured during 1985 in West Virginia, USA, diverged from strains of Four Corners virus from the southwestern USA by more than 16% and 6% at the nucleotide and amino acid levels, respectively. Phylogenetic analysis suggested that this virus strain (designated Monongahela) forms a possible evolutionary link between the Four Corners and New York hantaviruses.
KW  - amino acid sequences
KW  - molecular genetics
KW  - phylogeny
KW  - RNA
KW  - small mammals
KW  - viral proteins
KW  - wild animals
KW  - USA
KW  - West Virginia
KW  - Hantavirus
KW  - Peromyscus maniculatus
KW  - Bunyaviridae
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Peromyscus
KW  - Sigmodontinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - USA
KW  - South Atlantic States of USA
KW  - biochemical genetics
KW  - Monongahela virus
KW  - protein sequences
KW  - ribonucleic acid
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500579&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of Borrelia burgdorferi genes encoding homologues of DNA-binding protein HU and ribosomal protein S20.
AU  - Tilly, K.
AU  - Fuhrman, J.
AU  - Campbell, J.
AU  - Samuels, D. S.
JO  - Microbiology (Reading)
JF  - Microbiology (Reading)
Y1  - 1996///
VL  - 142
IS  - 9
SP  - 2471
EP  - 2479
SN  - 1350-0872
AD  - Tilly, K.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19960505771.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref. Registry Number: 9007-49-2.  Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2  - Linear DNA with covalently closed ends is the predominant form of DNA in the spirochaete B. burgdorferi. All bacteria examined to date have small DNA-binding proteins related to the Escherichia coli IHF and HU proteins that appear to play roles in DNA compaction and replication, but such proteins had not been isolated from bacteria with linear genomes. The authors found a single gene in B. burgdorferi (named hbb) whose product (named Hbb) complements the defects for λ DNA packaging found in E. coli strains mutant in the genes for IHF and HU. The sequence of the predicted B. burgdorferi protein is similar to those of HU and IHF-like proteins in other bacteria. The gene appears to be in an operon with the order rpsT-hbb-orfH, where the rpsT gene is a homologue of the E. coli gene encoding ribosomal protein S20 and the orfH gene encodes a protein of unknown function. This operon is located upstream of the previously identified B. burgdorferi rho homologue.
KW  - amino acid sequences
KW  - binding proteins
KW  - DNA
KW  - genes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - proteins
KW  - ribosomes
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - carrier proteins
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - HU protein
KW  - integration host factor
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960505771&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Measurement of exposure to nutrients: an approach to the selection of informative foods.
AU  - Mark, S. D.
AU  - Thomas, D. G.
AU  - Decarli, A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 143
IS  - 5
SP  - 514
EP  - 521
SN  - 0002-9262
AD  - Mark, S. D.: Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892-7368, USA.
N1  - Accession Number: 19961407583.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Human Nutrition
KW  - diet study techniques
KW  - questionnaires
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Techniques and Methodology (ZZ900) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407583&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation.
AU  - Mark, S. D.
AU  - Wang Wen
AU  - Fraumeni, J. F., Jr.
AU  - Li JunYao
AU  - Taylor, P. R.
AU  - Wang GuoQing
AU  - Guo, W.
AU  - Dawsey, S. M.
AU  - Li Bing
AU  - Blot, W. J.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 143
IS  - 7
SP  - 658
EP  - 664
SN  - 0002-9262
AD  - Mark, S. D.: National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961406837.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Human Nutrition
N2  - 3318 men and women (40-69 years old) from a region in rural China were randomized to receive daily either a multiple vitamin/mineral supplement or a placebo. Deaths that occurred in the participants were ascertained and classified according to cause over the 6-year period from 1985 to 1991. At the end of supplementation, blood pressure readings were taken, and the prevalence of hypertension was determined. There was a slight reduction in overall mortality in the supplement group (relative risk (RR) = 0.93, 95% confidence interval (CI) 0.75-1.16), with the decreased relative risk most pronounced for cerebrovascular disease deaths (RR = 0.63, 95% CI 0.37-1.07). This benefit was greater for men (RR = 0.42, 95% CI 0.19-0.93) than for women (RR = 0.93, 95% CI 0.44-1.98). Among the survivors, the presence of elevations in both systolic and diastolic blood pressures were less common in those who received the supplement (RR for men = 0.43, 95% CI 0.28-0.65; RR for women = 0.92, 95% CI 0.68-1.24). This study indicates that supplementation with a multivitamin/mineral combination may have reduced mortality from cerebrovascular disease and the prevalence of hypertension in this rural population with a micronutrient-poor diet.
KW  - antioxidants
KW  - cardiovascular diseases
KW  - hypertension
KW  - mineral supplements
KW  - minerals
KW  - stroke
KW  - vitamin supplements
KW  - vitamins
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - high blood pressure
KW  - People's Republic of China
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406837&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary assessment in epidemiology: comparison of a food frequency and a diet history questionnaire with a 7-day food record.
AU  - Jain, M.
AU  - Howe, G. R.
AU  - Rohan, T.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 143
IS  - 9
SP  - 953
EP  - 960
SN  - 0002-9262
AD  - Jain, M.: National Cancer Institute of Canada (NCIC) Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Ontario, Canada.
N1  - Accession Number: 19961409181.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Human Nutrition
N2  - The validity of 2 types of diet assessment methods, a self-administered food frequency questionnaire and an interviewer-administered detailed diet history, was assessed relative to a 7-day food record on a population-based sample of 95 men and 108 women in Toronto, Canada, between May 1989 and July 1990. Each study subject completed both questionnaire methods, a food frequency questionnaire and an interviewer-administered diet history, as well as a 7-day food record in a crossover design. Data were analysed for unadjusted and energy-adjusted nutrients to estimate Pearson's and intraclass correlations and agreement within categories. Mean values for the intake of most nutrients assessed by both questionnaire methods were similar. Average, energy-adjusted Pearson's correlation coefficients for men between a food frequency questionnaire and a 7-day food record were 0.55 for macronutrients and 0.48 for micronutrients compared with 0.47 for macro- and 0.48 for micronutrients between an interviewer-administered diet history and a 7-day food record. For women, they were 0.48 for macro- and 0.54 for micronutrients between a food frequency questionnaire and a 7-day food record and 0.46 and 0.49, respectively, between an interviewer-administered diet history and a 7-day food record. The energy-adjusted Pearson correlations were generally higher than were the energy-unadjusted Pearson correlations and the intraclass correlations. The results suggest that a food frequency questionnaire is comparable with an interviewer-administered diet history as a predictor of nutrients as estimated from a 7-day food record.
KW  - diet study techniques
KW  - epidemiology
KW  - questionnaires
KW  - sex differences
KW  - Canada
KW  - Ontario
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Canada
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prospective study of relative weight and risk of breast cancer: the Breast Cancer Detection Demonstration Project follow-up study, 1979 to 1987-1989.
AU  - Yong LeeChen
AU  - Brown, C. C.
AU  - Schatzkin, A.
AU  - Schairer, C.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 143
IS  - 10
SP  - 985
EP  - 995
SN  - 0002-9262
AD  - Yong LeeChen: Cancer Prevention Studies Branch, DCPC, National Cancer Institute, EPN, Room 211, 6130 Executive Blvd., MSC 7326, Rockville, MD 20852, USA.
N1  - Accession Number: 19962006210.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Human Nutrition; Public Health
N2  - The relation between adult relative weight (weight (kg)/height (m)1.5) and breast cancer risk was prospectively examined in a cohort of 54 896 women aged 31-89 years who had previously participated in the Breast Cancer Detection Demonstration Project in the USA. During a mean follow-up period of 7 years, 226 of the premenopausal women and 1198 of the postmenopausal women developed breast cancer. Analysis was performed using Cox proportional hazards regression methods with age as the underlying time variable and adjusted for the effects of potential confounders. Among postmenopausal women, the risk of breast cancer increased with increasing relative weight (P &lt;0.05 for trend); relative risk for the highest compared with the lowest quintile for relative weight was 1.3 (95% confidence interval (CI) 1.1-1.6). This association was modified by age at diagnosis, with relative risks of 1.1 (95% CI 0.8-1.4), 1.2 (95% CI 0.8-1.7), and 1.8 (95% CI 1.3-2.5), respectively, for women aged &lt;60, 60-64, and ≥65 years. The higher risk of breast cancer among the older and overweight women was largely confined to women whose weights were measured during the postmenopausal but not the premenopausal period. This risk pattern was observed among the naturally menopausal women, but was also apparent in the smaller group of women with bilateral oophorectomy or hysterectomy with one ovary retained. Among premenopausal women, adult relative weight was not associated with breast cancer risk. These findings suggest that the inconsistencies in the literature on obesity and breast cancer may be due in part to the differing age distributions of the populations studied. It is concluded that prevention of obesity throughout adulthood, particularly after menopause, may help reduce breast cancer among older women.
KW  - age differences
KW  - body weight
KW  - breast
KW  - breast cancer
KW  - neoplasms
KW  - obesity
KW  - risk factors
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - fatness
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006210&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - NHLBI Family Heart Study: objectives and design.
AU  - Higgins, M.
AU  - Province, M.
AU  - Heiss, G.
AU  - Eckfeldt, J.
AU  - Ellison, R. C.
AU  - Folsom, A. R.
AU  - Rao, D. C.
AU  - Sprafka, J. M.
AU  - Williams, R.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 143
IS  - 12
SP  - 1219
EP  - 1228
SN  - 0002-9262
AD  - Higgins, M.: National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
N1  - Accession Number: 19962007119.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Human Nutrition
N2  - The NHLBI Family Heart Study is a multicentre, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD), atherosclerosis, and cardiovascular risk factors. In phase I, 2000 randomly selected participants and 2000 with family histories of CHD were identified among 14 592 middle-aged participants in epidemiological studies in the USA. Medical histories from these individuals, their parents and their siblings were used to calculate family risk scores that compared the number of reported and validated CHD events with the number expected based on the size, sex and age of family members. A total of 657 families with the highest risk scores and early-onset CHD and 588 randomly sampled families had clinic examinations that included electrocardiograms, carotid artery ultrasound scans, spirometry, measurements of body size, blood pressure, lipids, lipoproteins, haemostatic factors, insulin, glucose and routine chemistries. Additional biochemical and genetic studies are being performed on selected participants. Serum, plasma, lymphocytes, red cells, and DNA are stored for future studies, including genotyping of candidate genes and anonymous markers. Contributions of genes, shared and individual environments, and behaviours to variations in risk factors, preclinical atherosclerosis, and CHD will be estimated. Linkage studies, including the quantitative trait loci approach, are planned.
KW  - cardiovascular diseases
KW  - clinical examination
KW  - epidemiology
KW  - heart diseases
KW  - human diseases
KW  - risk factors
KW  - screening
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - coronary diseases
KW  - screening tests
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007119&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Benign thyroid tumors: general risk factors and their effects on radiation risk estimation.
AU  - Wong, F. L.
AU  - Ron, E.
AU  - Gierlowski, T.
AU  - Schneider, A. B.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 144
IS  - 8
SP  - 728
EP  - 733
SN  - 0002-9262
AD  - Wong, F. L.: Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972000606.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Public Health
N2  - Risk factors for benign thyroid nodules and their influence on radiation effects were examined among 544 subjects who were exposed to childhood radiation treatment for benign head and neck conditions at a hospital in Chicago, Illinois, USA, during 1939-1962. In follow-up through 1991, benign thyroid nodules were diagnosed in 131 patients. The risk of benign nodules was elevated in women (relative risk (RR) = 2.2, 95% confidence interval (CI) 1.6-3.2), Jews (RR = 1.7, 95% CI 1.1-2.5), college graduates (RR = 1.8, 95% CI 1.2-2.8), and subjects whose mother had cancer (RR = 1.7, 95% CI 1.2-2.5). There were increasing trends for risk with increasing body mass index in women and decreasing height in men. Risk was increased for women who never married (RR = 3.7, 95% CI 1.6-7.3) or who never had a full-term pregnancy (RR = 2.0, 95% CI 1.1-3.3). A significant radiation dose-response relationship was observed that was not modified by sex, education, Jewish religion, or reproductive factors. The data suggest that there are genetic, life-style (including ascertainment), and hormonal factors associated with the development of benign thyroid nodules.
KW  - benign course
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - neoplasms
KW  - radiation
KW  - risk factors
KW  - thyroid gland
KW  - Illinois
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - East North Central States of USA
KW  - cancers
KW  - thyroid
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000606&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Maternal smoking during pregnancy and childhood cancer.
AU  - Klebanoff, M. A.
AU  - Clemens, J. D.
AU  - Read, J. S.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1996///
VL  - 144
IS  - 11
SP  - 1028
EP  - 1033
SN  - 0002-9262
AD  - Klebanoff, M. A.: National Institute of Child Health and Human Development, National Institutes of Health, 6100 Building, Room 7B03, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19972003105.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Public Health
N2  - The association between maternal smoking during pregnancy and childhood cancer was investigated using prospectively collected data from 54 795 liveborn children in the Collaborative Perinatal Project (1959-1966) in the USA. Cases of cancer had a histological diagnosis and/or a compatible clinical course. There were 51 children with cancer, for a cumulative incidence of cancer of 1.1 per 1000 by 96 months of age. Maternal smoking was determined at each prenatal visit; 52% of mothers reported smoking at 1 or more visits. By age 8 years, cancer had occurred in 1.4 per 1000 children whose mothers did not smoke during pregnancy, compared with 0.9 per 1000 children whose mothers smoked (P = 0.15 by log rank test); the hazard ratio was 0.67 (95% confidence interval (CI) 0.38-1.17). There was no dose-response effect of smoking compared with nonsmokers (hazard ratio for 1 to 10 cigarettes/day = 0.45, more than 10 cigarettes/day = 0.83). The hazard ratio for leukaemia among children whose mothers smoked was 0.82 (95% CI 0.31-2.11); the hazard ratio for cancers other than leukaemia was 0.60 (95% CI 0.30-1.20). Adjustment did not change the hazard ratio substantially. Although the relatively small number of cases precluded extensive study of individual types of cancer, it is concluded that maternal smoking during pregnancy is not associated with an increased risk of childhood cancer in this cohort.
KW  - carcinogens
KW  - children
KW  - effects
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - leukaemia
KW  - mothers
KW  - neoplasms
KW  - pregnancy
KW  - risk factors
KW  - tobacco smoking
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - blood cancer
KW  - cancers
KW  - gestation
KW  - leucaemia
KW  - leukemia
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003105&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fruit and vegetable intakes of children and adolescents in the United States.
AU  - Krebs-Smith, S. M.
AU  - Cook, D. A.
AU  - Subar, A. F.
AU  - Cleveland, L.
AU  - Friday, J.
AU  - Kahle, L. L.
JO  - Archives of Pediatrics & Adolescent Medicine
JF  - Archives of Pediatrics & Adolescent Medicine
Y1  - 1996///
VL  - 150
IS  - 1
SP  - 81
EP  - 86
AD  - Krebs-Smith, S. M.: National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19961403448.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Human Nutrition; Potatoes
N2  - To identify the ways in which fruits and vegetables are consumed by children, to provide estimates of their intakes compared with recommendations, and to estimate the percentage of children meeting those recommendations, 3 days of dietary data from respondents in the US Department of Agriculture's 1989-1991 Continuing Survey of Food Intakes by Individuals were examined. All foods reported in the survey were disaggregated into their component ingredients; all fruit and vegetable ingredients were assigned specific weights to correspond with a serving as defined by current dietary guidance materials; and the number of servings of each fruit and vegetable was tallied. A total of 3148 children and adolescents aged 2 to 18 years were studied. Percentages of fruit and vegetable servings consumed in various forms, mean number of servings consumed per day, and percentage of persons meeting various recommendations by sex/age, race/ethnicity and household income were estimated. Nearly one-quarter of all vegetables consumed by children and adolescents were french fries [potato chips]. Their intakes of all fruits and of dark green and/or deep yellow vegetables were very low compared with recommendations. Only 1 in 5 children consumed 5 or more servings of fruits and vegetables per day. Paediatricians should encourage the consumption of fruits and vegetables, especially dark green and deep yellow vegetables, by children.
KW  - adolescents
KW  - children
KW  - chips (French fries)
KW  - crisps
KW  - diet studies
KW  - fruit
KW  - guidelines
KW  - intake
KW  - nutrition
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - French fries
KW  - potato chips
KW  - recommendations
KW  - teenagers
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Crop Produce (QQ050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pollutants in breast milk.
AU  - Rogan, W. J.
JO  - Archives of Pediatrics & Adolescent Medicine
JF  - Archives of Pediatrics & Adolescent Medicine
Y1  - 1996///
VL  - 150
IS  - 9
SP  - 981
EP  - 990
AD  - Rogan, W. J.: Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
N1  - Accession Number: 19960404549.  Publication Type: Journal Article.  Language: English.  Number of References: 102 ref. Registry Number: 72-55-9, 50-29-3, 118-74-1.  Subject Subsets: Dairy Science; Human Nutrition; Agricultural Entomology; Medical & Veterinary Entomology
N2  - A review is presented including: chemical agents of interest; geography; multiple congeners and mixtures; polychlorinated biphenyls and polychlorinated dibenzofurans; 2,3,7,8-tetrachlorodibenzo-p-dioxin; polychlorinated biphenyls; DDT and DDE; polybrominated biphenyls; the cyclodienes; hexachlorobenzene; risk of cancer for the child; cancer in the mother; and prevention.
KW  - agricultural entomology
KW  - congeners
KW  - dde
KW  - ddt
KW  - herbicides
KW  - hexachlorobenzene
KW  - human milk
KW  - infant feeding
KW  - infants
KW  - insecticide residues
KW  - insecticides
KW  - mothers
KW  - neoplasms
KW  - nontarget effects
KW  - organochlorine compounds
KW  - pesticide residues
KW  - pesticides
KW  - pollutants
KW  - polybrominated biphenyls
KW  - polychlorinated biphenyls
KW  - polychlorinated dibenzodioxins
KW  - polychlorinated dibenzofurans
KW  - residues
KW  - reviews
KW  - risk
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - breast milk
KW  - cancers
KW  - cyclodienes
KW  - dicophane
KW  - HCB
KW  - organic chlorine compounds
KW  - p,p'-dichlorodiphenyldichloroethylene
KW  - PCBs
KW  - weedicides
KW  - weedkillers
KW  - Milk and Dairy Produce (QQ010) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Toxoplasma gondii infection induces specific nonresponsiveness in lymphocytes bearing the VΒ5 chain of the mouse T cell receptor.
AU  - Denkers, E. Y.
AU  - Caspar, P.
AU  - Hieny, S.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 156
IS  - 3
SP  - 1089
EP  - 1094
SN  - 0022-1767
AD  - Denkers, E. Y.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962004395.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Registry Number: 9008-11-1.  Subject Subsets: Tropical Diseases; Protozoology
N2  - The authors recently reported a superantigen activity associated with Toxoplasma gondii tachyzoites that in vitro induces preferential expansion of VΒ5+ T lymphocytes following parasite stimulation of nonimmune cells. In the experiments presented in this work, VΒ5+ lymphocyte function was examined ex vivo using mice undergoing chronic and acute infection with the avirulent parasite strain ME49 or acutely infected with the attenuated mutant ts-4. Cells bearing the TCR VΒ5 chain were found to be increased by 1.5- to 2-fold during acute infection, whereas during the chronic phase, modest decreases (~20%) in cells of the latter subset were observed. When splenocytes from chronically infected animals were stimulated in vitro with tachyzoites, the preferential expansion of VΒ5+ lymphocytes seen using cells from normal mice was not observed. Furthermore, when purified T lymphocytes were cultured with plate-bound VΒ5-specific MAb, the authors found that in contrast to normal and acutely infected animals, cells from chronically infected and ts-4-vaccinated mice were nonresponsive to TCR-induced stimulation (70% to 90% reduction relative to normal cells). In control experiments, mAb to CD3 and VΒ8 elicited normal responses in the same animals. Similarly, in contrast to normal splenocytes, cells from chronically infected mice failed to produce IFN-γ in response to anti-VΒ5 MAb. These data indicate that VΒ5+ cells are rendered nonresponsive as a result of in vivo encounter with T. gondii, and as such they provide the first demonstration of VΒ-specific anergy induced by a protozoan parasite.
KW  - disease models
KW  - experimental infections
KW  - immune response
KW  - interferon
KW  - laboratory animals
KW  - monoclonal antibodies
KW  - parasites
KW  - T lymphocytes
KW  - tachyzoites
KW  - toxoplasmosis
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Contribution of nitric oxide to the host parasite equilibrium in toxoplasmosis.
AU  - Hayashi, S.
AU  - Chan ChiChao
AU  - Gazzinelli, R.
AU  - Roberge, F. G.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 156
IS  - 4
SP  - 1476
EP  - 1481
SN  - 0022-1767
AD  - Hayashi, S.: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.
N1  - Accession Number: 19960803261.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 10102-43-9.  Subject Subsets: Protozoology
N2  - The effect of nitric oxide (NO) production on the evolution of toxoplasmosis in C57BL/6 mice was examined. Infection was induced by ip injection of Toxoplasma gondii strain ME49. NO synthesis was inhibited by treatment with aminoguanidine, a structural analogue of L-arginine. The severity of infection was evaluated by histopathologic examination of the brain. In the infected mice treated for 2 weeks with aminoguanidine, an increase in the number of Toxoplasma tachyzoites and intracellular cysts was observed accompanied by an exacerbated inflammation of the brain tissue compared with that in controls. When spleen cells from infected mice were stimulated in culture with Toxoplasma antigen, there was a marked cytotoxic effect on cells collected during the acute stage of infection and an inhibition of proliferation of the remaining viable lymphocytes. These effects were correlated with high levels of NO and PGE2 production. The suppression of NO synthesis prevented cell death and restored the lymphocyte proliferative response as well as lymphokine production. The neutralization of IFN-γ or TNF-α had no effect on NO production in the cultures of infected mouse spleen cells. Cultures in which purified macrophages and lymphocytes from infected and naive mice were mixed indicated that the production of NO was dependent on lymphocyte activation. In the later stages of infection, when the production of NO was abating, preventing PGE2 secretion with indomethacin also increased the lymphocyte proliferative response. It is concluded that the opposing effects of NO in toxoplasmosis, which protects against Toxoplasma gondii and at the same time limits the immune response, probably contribute to the establishment of the characteristic chronic state of host parasite equilibrium.
KW  - chronic infections
KW  - cytokines
KW  - experimental infections
KW  - human diseases
KW  - immune response
KW  - immunopathology
KW  - laboratory animals
KW  - nitric oxide
KW  - parasites
KW  - toxoplasmosis
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice.
AU  - Kullberg, M. C.
AU  - Berzofsky, J. A.
AU  - Jankovic, D. L.
AU  - Barbieri, S.
AU  - Williams, M. E.
AU  - Perlmann, P.
AU  - Sher, A.
AU  - Troye-Blomberg, M.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 156
IS  - 4
SP  - 1482
EP  - 1489
SN  - 0022-1767
AD  - Kullberg, M. C.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892.
N1  - Accession Number: 19960803262.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 148641-02-5, 207137-56-2.  Subject Subsets: Helminthology
N2  - A novel amplification mechanism underlying the increased early IL-4 production observed in Schistosoma mansoni-infected mice in response to sperm whale myoglobin (SwMb) is described. Earlier studies have shown that splenic FcεR+ non-B, non-T (NBNT) cells from schistosome-infected mice secrete IL-4 after stimulation with parasite antigen. It is demonstrated that purified NBNT cells from SwMb-immunized S. mansoni-infected mice do not respond directly to SwMb, but produce IL-4 in response to IL-3. Accordingly, it is shown that the early SwMb-specific IL-4 response of spleen cells (SC) from immunized infected mice is dependent on IL-3 and on CD4+ T cells. Thus, most of the early SwMb-induced IL-4 from SC of infected mice appears to be produced by NBNT cells triggered by IL-3 synthesized by SwMb-specific CD4+ T cells. IL-3-induced IL-4 production was also observed in purified NBNT cells from immunized uninfected mice, but the frequency and/or IL-4-producing capacity of splenic IL-3-responsive cells was found to be 8 to 16 times higher in immunized infected animals. IL-4 production by purified CD4+ cells from immunized infected mice was also seen after SwMb stimulation, but this response showed slower kinetics than those of total SC, was IL-3-independent, and on average threefold greater than that by CD4+ cells from immunized uninfected controls. Thus, increased SwMb-induced IL-4 production in immunized S. mansoni-infected mice results from direct synthesis by CD4+ T cells, as well as their stimulation via IL-3 of an expanded population of NBNT cells. The latter pathway may serve as an amplification loop for Th2-cytokine responses.
KW  - antigens
KW  - helminths
KW  - immune response
KW  - interleukin 3
KW  - interleukin 4
KW  - laboratory animals
KW  - myoglobin
KW  - parasites
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for distinct contributions of heavy and light chains to restriction of antibody recognition of the HIV-1 principal neutralization determinant.
AU  - Watkins, B. A.
AU  - Davis, A. E.
AU  - Fiorentini, S.
AU  - MarzoVeronese, F. di
AU  - Reitz, M. S., Jr.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 156
IS  - 4
SP  - 1676
EP  - 1683
SN  - 0022-1767
AD  - Watkins, B. A.: Laboratory of Tumor Cell Biology, National Cancer Institute, Building 37, Room 6C09, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962004338.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - monoclonal antibodies
KW  - neutralization
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interference between human herpesvirus 7 and HIV-1 in mononuclear phagocytes.
AU  - Crowley, R. W.
AU  - Secchiero, P.
AU  - Zella, D.
AU  - Cara, A.
AU  - Gallo, R. C.
AU  - Lusso, P.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 156
IS  - 5
SP  - 2004
EP  - 2008
SN  - 0022-1767
AD  - Crowley, R. W.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972000883.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref.
KW  - CD4 antigens
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - inhibition
KW  - interactions
KW  - macrophages
KW  - monocytes
KW  - pathogenesis
KW  - receptors
KW  - human herpesvirus 7
KW  - Human immunodeficiency virus 1
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - CD4
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000883&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Weight change between age 50 years and old age is associated with risk of hip fracture in white women aged 67 years and older.
AU  - Langlois, J. A.
AU  - Harris, T.
AU  - Looker, A. C.
AU  - Madans, J.
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
Y1  - 1996///
VL  - 156
IS  - 9
SP  - 989
EP  - 994
SN  - 0003-9926
AD  - Langlois, J. A.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD, USA.
N1  - Accession Number: 19961409651.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref. Subject Subsets: Human Nutrition
N2  - A study was conducted to examine the effects of weight loss and weight gain from age 50 years to old age on the risk of hip fracture among 3683 postmenopausal white women aged ≥67 years and to determine if the level of weight at age 50 years modifies this risk. Extreme weight loss (≥10%) beginning at age 50 years was associated in a proportional hazards model with increased risk of hip fracture (relative risk (RR), 2.9; 95% confidence interval (CI), 2.0-4.1). This risk was greatest among women in the lowest (RR, 2.3; CI, 1.1-4.8) and middle (RR, 2.8; CI, 1.5-5.3) tertiles of body mass index at age 50 years. Among the thinnest women, even more modest weight loss (5% to &lt;10%) was associated with increased risk of hip fracture (RR, 2.3; CI, 1.0-5.2). Weight gain of ≥10% beginning at age 50 years provided borderline protection against the risk of hip fracture (RR, 0.7; CI, 0.4-1.0). The RRs for weight gain of ≥10% were protective only among women in the middle and high tertiles of body mass index at age 50 years and were not significant (middle tertile RR, 0.8; CI, 0.3-1.8; high tertile RR, 0.6; CI, 0.2-1.9). Weight history is an important determinant of the risk of hip fracture. Weight loss beginning at age 50 years increases the risk of hip fracture in older white women, especially among those who are thin at age 50 years; weight gain of ≥10% decreases the risk of hip fracture. Physicians should include weight history in their assessment of postmenopausal older women for risk of hip fracture.
KW  - body weight
KW  - bone fractures
KW  - history
KW  - old age
KW  - risk
KW  - weight gain
KW  - weight reduction
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Modulation of endogenous IL-1β and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells.
AU  - Goletti, D.
AU  - Kinter, A. L.
AU  - Hardy, E. C.
AU  - Poli, G.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 156
IS  - 9
SP  - 3501
EP  - 3508
SN  - 0022-1767
AD  - Goletti, D.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972005560.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref.
KW  - colony stimulating factor
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunopathology
KW  - inhibitors
KW  - interleukin 1
KW  - monocytes
KW  - pathogenesis
KW  - receptors
KW  - replication
KW  - synergism
KW  - transcription factors
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - synergy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005560&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epitope mapping by mass spectrometry. Determination of an epitope on HIV-1IIIB p26 recognized by a monoclonal antibody.
AU  - Parker, C. E.
AU  - Papac, D. I.
AU  - Trojak, S. K.
AU  - Tomer, K. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 1
SP  - 198
EP  - 206
SN  - 0022-1767
AD  - Parker, C. E.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19972000895.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - Matrix-assisted laser desorption mass spectrometry in combination with proteolytic protection assays has been used to identify the functional epitope on HIV-1IIIB p26 recognized by a monoclonal antibody (mAb). In this procedure, the intact protein is affinity bound to an immobilized mAb under physiological conditions. A combination of proteolytic enzymatic cleavages was then performed to remove unprotected residues. Protected residues were identified by matrix-assisted laser desorption mass spectrometry based on their molecular weight. With this approach, an 11-residue sequence was identified as the most tightly affinity-bound fragment. In addition, two less tightly bound segments were observed. These latter two residues may contain elements of a discontinuous epitope or may be residues involved in a wider contact area. The combination of matrix-assisted laser desorption and proteolytic epitope footprinting has been applied to the determination of the epitope on a recombinant protein recognized by a mAb but should be equally applicable to the definition of an epitope on a native protein in its natural folded conformation.
KW  - coat proteins
KW  - epitopes
KW  - Gag protein
KW  - HIV-1 infections
KW  - human diseases
KW  - laboratory methods
KW  - mass spectrometry
KW  - techniques
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenic determinants
KW  - capsid proteins
KW  - human immunodeficiency virus type 1
KW  - laboratory techniques
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Defective monocyte costimulation for IFN-γ production in familial disseminated Mycobacterium avium complex infection.
AU  - Frucht, D. M.
AU  - Holland, S. M.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 1
SP  - 411
EP  - 416
SN  - 0022-1767
AD  - Frucht, D. M.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962008191.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 9008-11-1. 
N2  - Six members of a family in which several members had disseminated Mycobacterium avium complex infection were studied. PHA-stimulated allogeneic cocultures of highly purified monocytes and T cells from familial patients and normal subjects, were used to show that familial patient monocytes were defective in accessory cell function for IFN-γ production. Familial patient monocytes did not inhibit IFN-γ production by normal cells, nor did inhibition of PG synthesis restore normal IFN-γ production by familial patient cells. Familial patient cells responded to the addition of exogenous IL-12 by increasing IFN-γ production, while addition of exogenous anti-IL-12 had an insignificant effect on their IFN-γ production. IL-12 was undetectable in PHA-stimulated cocultures of familial patient monocytes with familial or normal T cells. In addition, IL-12 production by adherent cells from patients and their unaffected mothers was abnormally low following stimulation with fixed Staphylococcus aureus Cowan I strain. However, normal amounts of IL-12 were detected when adherent familial patient cells were stimulated with S. aureus Cowan I strain and IFN-γ, suggesting abnormal regulation of IL-12 production by familial monocytes. It was concluded that defective IL-12 production was associated with increased susceptibility to an infectious disease, a finding that supports the critical role of this cytokine in host defence.
KW  - bacterial diseases
KW  - cytokines
KW  - human diseases
KW  - immune response
KW  - infections
KW  - interferon
KW  - interleukins
KW  - monocytes
KW  - susceptibility
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium avium complex
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008191&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α.
AU  - Gazzinelli, R. T.
AU  - Wysocka, M.
AU  - Hieny, S.
AU  - Scharton-Kersten, T.
AU  - Cheever, A.
AU  - Kühn, R.
AU  - Müller, W.
AU  - Trinchieri, G.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 2
SP  - 798
EP  - 805
SN  - 0022-1767
AD  - Gazzinelli, R. T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970801911.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 9008-11-1, 130068-27-8, 308079-78-9.  Subject Subsets: Protozoology
N2  - To examine the function of interleukin (IL)-10 synthesis during early infection with Toxoplasma gondii, IL-10 knockout (KO) mice were inoculated with an avirulent parasite strain (ME-49). In contrast to control mice that displayed 100% survival, the IL-10-deficient animals succumbed within the first 2 weeks of infection with no evidence of enhanced parasite proliferation. The mortality in the IL-10 KO mice was associated with enhanced liver pathology characterized by increased cellular infiltration and intense necrosis. Levels of IL-12 and interferon (IFN)-γ in sera of infected IL-10-deficient animals were 4- to 6-fold higher than those in sera from control mice, as were mRNA levels for IFN-γ, IL-1β, tumour necrosis factor (TNF)-α and IL-12 in lung tissue. Macrophages from IL-10 KO mice activated in vitro or in vivo with T. gondii produced higher levels of TNF-α and IL-12 than macrophages from controls, and spleen cells from IL-10 KO mice infected with T. gondii secreted more IFN-γ than splenocytes from nondeficient animals. In vitro depletion experiments indicated that CD4+ lymphocytes are the major source of IFN-γ in the spleen cell populations, and in vivo depletion with anti-CD4 antibodies protected the IL-10 KO mice from parasite-induced mortality. The results suggest that endogenous IL-10 synthesis plays an important role in down-regulating monokine and IFN-γ responses to acute intracellular infection, thereby preventing host immunopathology.
KW  - antibodies
KW  - cells
KW  - cytokines
KW  - experimental infection
KW  - immune response
KW  - immunopathology
KW  - in vitro
KW  - interferon
KW  - interleukin 10
KW  - interleukins
KW  - laboratory animals
KW  - liver
KW  - lungs
KW  - macrophages
KW  - mortality
KW  - parasites
KW  - pathology
KW  - spleen
KW  - strains
KW  - T lymphocytes
KW  - tumour necrosis factor
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cachectin
KW  - cachexin
KW  - death rate
KW  - experimental transmission
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - T cells
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni.
AU  - Jankovic, D.
AU  - Åslund, L.
AU  - Oswald, I. P.
AU  - Caspar, P.
AU  - Champion, C.
AU  - Pearce, E.
AU  - Coligan, J. E.
AU  - Strand, M.
AU  - Sher, A.
AU  - James, S. L.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 2
SP  - 806
EP  - 814
SN  - 0022-1767
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970801804.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 9008-11-1.  Subject Subsets: Helminthology
N2  - A CD4+ clone (clone B), characterized as Th1 based on its selective production of interferon (IFN)-γ and interleukin-2, was established from C57BI/6 mice protectively immunized against Schistosoma mansoni by intradermal vaccination with soluble worm antigens plus bacillus Calmette Guérin. In agreement with previous results which demonstrated an IFN-γ-dependent cell-mediated protective mechanism in this vaccination model, antigen-elicited peritoneal macrophages from syngeneic recipients of this clone were activated to kill schistosomula in vitro. Recipients of clone B also displayed significant resistance against cercarial challenge. By screening a battery of λgt11 clones from an adult worm cDNA library, one recombinant (25B) was identified that stimulated clone B specifically. Analysis of the 25B cDNA insert revealed a nucleotide sequence identical with that of the large subunit of schistosome calpain, a Ca2+-activated neutral proteinase. By expressing the products of polymerase chain reaction subcloning, a 146-amino acid region of the 25B gene was identified which contained immunological activity equivalent to the whole polypeptide. Overlapping peptides spanning this region were synthesized and a core epitope was identified with the sequence EWKGAWCDGS. Since clone B responded to supernatants from cultured schistosomula, it was postulated that the recognition of calpain released by invading larvae and the resulting induction of Th1 cytokines accounts for the protection mediated by the adoptively transferred clone. Calpain is therefore implicated as a target of protective immunity in schistosomes and provides the first example of a candidate vaccine antigen for this parasite identified on the basis of T cell reactivity.
KW  - amino acids
KW  - antigens
KW  - cercariae
KW  - clones
KW  - developmental stages
KW  - digenean larvae
KW  - DNA libraries
KW  - epitopes
KW  - experimental infections
KW  - helminths
KW  - immune response
KW  - immunization
KW  - in vitro
KW  - interferon
KW  - laboratory animals
KW  - macrophages
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - peptides
KW  - polymerase chain reaction
KW  - proteinases
KW  - recombinant vaccines
KW  - schistosomula
KW  - T lymphocytes
KW  - vaccines
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - antigenic determinants
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA sequences
KW  - growth phase
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - parasitic worms
KW  - PCR
KW  - proteases
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.
AU  - Lafrenie, R. M.
AU  - Wahl, L. M.
AU  - Epstein, J. S.
AU  - Hewlett, I. K.
AU  - Yamada, K. M.
AU  - Dhawan, S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 3
SP  - 974
EP  - 977
SN  - 0022-1767
AD  - Lafrenie, R. M.: Laboratory of Developmental Biology, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19962009003.  Publication Type: Journal Article.  Language: English. 
N2  - Monocytes are susceptible to HIV infection and to activation by a regulatory gene product of the HIV genome, HIV-Tat. Recently, it has been demonstrated that treatment with HIV-Tat up-regulates monocyte adhesion to the endothelium and increases metalloproteinase production. In the present study, the authors examined the ability of the HIV-Tat protein to alter the migratory and invasive behaviour of monocytes. Monocytes pretreated for 24 h with 10 ng/ml HIV-Tat exhibited enhanced migratory behaviour compared with untreated monocytes in chemotaxis assays, both in the absence of a chemoattractant as well as in response to FMLP. In addition, HIV-Tat itself induced the migration of both untreated and HIV-Tat pretreated monocytes. Checkerboard analysis showed that monocytes migrated in response to an HIV-Tat concentration gradient, thus confirming the chemotactic characteristics of the HIV-Tat protein. Pretreatment of monocytes with 10 ng/ml HIV-Tat for 24 h also increased their ability to invade reconstituted extracellular membrane (Matrigel)-coated filters by 5-fold in the absence of chemoattractant. The presence of FMLP or HIV-Tat further enhanced invasion by both untreated and HIV-Tat-pretreated monocytes by more than 10-fold. Monocyte invasion was partially inhibited by the inclusion of anti-β1 integrin Ab or tissue inhibitor of metalloproteinase (TIMP). Thus, for the first time, evidence is presented that HIV-Tat can enhance the chemotactic and invasive behaviours of monocytes and an active role is proposed for HIV-Tat in the recruitment of monocytes into extravascular tissues, a process which may contribute to the destruction of tissues and cellular architecture often seen in patients with AIDS.
KW  - chemotaxis
KW  - HIV-1 infections
KW  - human diseases
KW  - monocytes
KW  - pathogenesis
KW  - Tat protein
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine.
AU  - Tian JingHui
AU  - Miller, L. H.
AU  - Kaslow, D. C.
AU  - Ahlers, J.
AU  - Good, M. F.
AU  - Alling, D. W.
AU  - Berzofsky, J. A.
AU  - Kumar, S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 3
SP  - 1176
EP  - 1183
SN  - 0022-1767
AD  - Tian JingHui: Laboratory of Parasitic Diseases, Building 4, Room 26, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970803904.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Protozoology; Animal Breeding
N2  - MSP1(19), the C-terminal 19-kDa, epidermal growth factor-like region of the merozoite surface protein 1 (MSP1), has been used as a vaccine to induce protective immunity to Plasmodium yoelii in mice and to P. falciparum in monkeys. To analyse the mechanisms and genetic regulation of this MSP1-vaccine-induced protection, the immunological correlates of protection were studied in 7 H-2 recombinant and congenic mouse strains on the B10 background. The recombinant protein was produced in Escherichia coli or Saccharomyces cerevisiae, and inoculated in 4 doses into 4 mice/group. Mice were challenged iv with 104 lethal P. yoelii 17 XL 7 days after the last dose. The number of survivors among the vaccinated mice depended on the H-2 haplotype, although the course of infection within each strain was variable; multiple H-2-linked loci were found to affect immunity, each with a different mechanism. One locus was concluded to be in the I-A region, based on the strong protection in C57BL/10 mice compared with intermediate protection in B10.A(4R) mice and the lack of a difference between B10.AKM and B10.MBR mice. Differences in efficacy of passively transferred antisera from vaccinated C57BL/10 vs B10.A(4R) mice, and in the level of immunity between vaccinated mice and those injected with sera, suggested that the protection regulated by the I-A locus was partly but not completely antibody-dependent. Two loci to the right of I-A (I-E, H-2S, or H-2D) also appeared to affect immunity, based on a correlation (P=0.03) between peak parasitaemia or mortality and the number of H-2k alleles to the right of I-A in mice that were I-Ak. One effect was antibody-independent and may correspond to a possible negative effect of the I-Ek allele. T cells from 1 nonprotected and 2 protected strains differed in their production of IFN-γ and TNF-α following immunization with MSP1(19) (the most protected strain produced less IFN-γ than the other 2, and both protected strains produced less TNF-α than the nonprotected one), but it was unclear how the differential patterns of cytokine expression related to the level of protection. It is concluded that MSP1(19)-vaccine-induced protection is regulated by H-2-linked loci corresponding to 2 different immune mechanisms. These findings may indicate the need for more than one antigen in a vaccine to protect an HLA-diverse population.
KW  - antibodies
KW  - experimental infections
KW  - immune response
KW  - immunization
KW  - immunogenetics
KW  - laboratory animals
KW  - major histocompatibility complex
KW  - malaria
KW  - merozoites
KW  - parasites
KW  - recombinant vaccines
KW  - surface proteins
KW  - T lymphocytes
KW  - vaccines
KW  - mice
KW  - Plasmodium yoelii
KW  - protozoa
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - histocompatibility complex
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - membrane proteins
KW  - merozoite surface protein 1
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation.
AU  - Goletti, D.
AU  - Weissman, D.
AU  - Jackson, R. W.
AU  - Graham, N. M. H.
AU  - Vlahov, D.
AU  - Klein, R. S.
AU  - Munsiff, S. S.
AU  - Ortona, L.
AU  - Cauda, R.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 3
SP  - 1271
EP  - 1278
SN  - 0022-1767
AD  - Goletti, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
N1  - Accession Number: 19962009004.  Publication Type: Journal Article.  Language: English. 
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - pathogenesis
KW  - t lymphocytes
KW  - Mycobacterium tuberculosis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.
AU  - Scharton-Kersten, T. M.
AU  - Wynn, T. A.
AU  - Denkers, E. Y.
AU  - Bala, S.
AU  - Grunvald, E.
AU  - Hieny, S.
AU  - Gazzinelli, R. T.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 9
SP  - 4045
EP  - 4054
SN  - 0022-1767
AD  - Scharton-Kersten, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970805445.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - The relationship between IFN-γ and IL-12 in generating innate immune responses and resistance to acute Toxoplasma gondii infection was assessed in IFN-γ knockout (gko) mice. Gko and wild type (wt) mice were inoculated with either the avirulent T. gondii strain ME49 (20 cysts per mouse) or the attenuated temperature-sensitive mutant strain ts4 (2 × 104 tachyzoites ip per mouse). The gko mice rapidly succumbed to infection with both strains of T. gondii. Microscopic examination of peritoneal exudates from infected gko mice demonstrated that mortality was associated with unchecked tachyzoite replication. However, both wt and gko mice developed a peritoneal inflammatory response that in gko mice was greater due to a 5- to 10-fold increase in the number of granulocytes recruited to the site of infection. In addition, measurement of IL-12 p40 in spleen and peritoneal cells on days 0, 3 and 5 pi, and a significant IL-12-dependent NK cell response showed that IL-12 production in gko mice was both unimpaired and functional (but lower than wt). No evidence for an IFN-γ-independent protective function for IL-12 or NK cells was apparent since in vivo treatment of gko mice with an IL-12-neutralizing mAb ablated the NK cell response, but did not decrease survival of the mice. It is concluded that there are distinct functions for IL-12 and IFN-γ in host resistance to T. gondii: IL-12 precedes and initiates synthesis of IFN-γ, while the latter lymphokine directly controls parasite growth and diminishes the contribution of IL-4 and IL-5 producing T-cell subsets.
KW  - acute infections
KW  - experimental infections
KW  - immune response
KW  - interferon
KW  - interleukin 12
KW  - laboratory animals
KW  - parasites
KW  - tachyzoites
KW  - toxoplasmosis
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - cysts
KW  - immunity reactions
KW  - immunological reactions
KW  - severe infections
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.
AU  - Wynn, T. A.
AU  - Reynolds, A.
AU  - James, S.
AU  - Cheever, A. W.
AU  - Caspar, P.
AU  - Hieny, S.
AU  - Jankovic, D.
AU  - Strand, M.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 9
SP  - 4068
EP  - 4078
SN  - 0022-1767
AD  - Wynn, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970805446.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Subject Subsets: Helminthology
N2  - The effects of administering IL-12 as an adjuvant on the development of a protective humoral response in multiply immunized mice was investigated. Female C57BL/6 mice were vaccinated by immersing their tails in water containing 500 irradiated cercariae of Schistosoma mansoni for 40 min. Multiply immunized mice were vaccinated 3 times at 4- to 5-week intervals. Following percutaneous challenge with unattenuated cercariae of S. mansoni, it was found that multiply immunized mice which received IL-12 at the time of vaccination displayed a marked increase in resistance to challenge infection, with some animals demonstrating complete protection. The IL-12 vaccinated mice developed strongly polarized Th1 responses but, importantly, also showed significant increases in parasite-specific antibody and, in particular, IgG2a, IgG2b, and IgG1 isotypes. Passive transfer demonstrated an enhanced ability of serum from these animals to protect naive recipients. In addition, mice vaccinated in the presence of IL-12 also developed macrophages with increased nitric oxide-dependent killing activity against the parasites. It is concluded that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell-mediated protective responses against infection.
KW  - animal models
KW  - experimental infections
KW  - helminths
KW  - humoral immunity
KW  - immune response
KW  - immunization
KW  - live vaccines
KW  - parasites
KW  - schistosomiasis
KW  - vaccination
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - attenuated vaccines
KW  - bilharzia
KW  - bilharziasis
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805446&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reciprocal cytotoxic T lymphocyte cross-reactivity interactions between two major epitopes within HIV-1 gp160.
AU  - Shirai, M.
AU  - Kurokohchi, K.
AU  - Pendleton, C. D.
AU  - Arichi, T.
AU  - Boyd, L. F.
AU  - Takahashi, H.
AU  - Margulies, D. H.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 10
SP  - 4399
EP  - 4411
SN  - 0022-1767
AD  - Shirai, M.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972003662.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref.
N2  - An unexpected observed cross-reactivity of CD8+ cytotoxic T lymphocytes (CTL) between 2 nonhomologous peptides of the HIV-1 IIIB gp160 envelope protein, P18 (residues 315-329) and HP53 (834-848, also called TH4.1), in the context of 4 different class I MHC molecules, Dd, Dp, Dq (or Lq) and H-2u was analysed. In strains expressing Dd, the cross-reactivity between peptides was bidirectional, whereas in other strains (H-2u, H-2p and H-2q), the cross-reactivity was unidirectional; that is, P18-specific CTLs showed no killing against targets pulsed with HP53, although HP53 stimulated CTL showed cross-reactive lysis against P18-pulsed target cells. Cross-reactivity was also shown in immunization in vivo and with target cells endogenously expressing viral protein in vitro using 2 different recombinant vaccinia viruses expressing only the N-terminal portion of gp160, containing P18 but not HP53. Peptide cross-contamination was excluded. Cold target inhibition and single cell cloning experiments indicated that the same CTL was responding to both peptides. Using substituted and truncated peptides, amino acid residues critical for cross-reactive CTL recognition were studied. Fine specificity similarities among all cross-reactive CTL lines but not non-cross-reactive lines were identified and cross-reactivity was mapped to a 10-residue core of P18 and to an 8-residue core of HP53. A comparison of these peptide sequences and recent data on residues of P18 interacting with H-2Dd provided clues to residues involved in the interaction of the CTL with the MHC-peptide complex.
KW  - amino acids
KW  - cell mediated immunity
KW  - cross reaction
KW  - cytotoxicity
KW  - envelope protein gp160
KW  - epitopes
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - interactions
KW  - lymphocytes
KW  - peptides
KW  - residues
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - cellular immunity
KW  - gp160
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003662&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-γ with patterns of tissue expression that suggest nonredundant roles in vivo.
AU  - Amichay, D.
AU  - Gazzinelli, R. T.
AU  - Karupiah, G.
AU  - Moench, T. R.
AU  - Sher, A.
AU  - Farber, J. M.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1996///
VL  - 157
IS  - 10
SP  - 4511
EP  - 4520
SN  - 0022-1767
AD  - Amichay, D.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 11N-228, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970802357.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - MuMig and Crg-2 are interferon (IFN)-inducible murine chemokines whose human homologues (HuMig and IP-10, respectively) share activity in vitro as T cell chemoattractants. The expression of the genes Mumig, crg-2 and IFN-γ were analysed during experimental infections of mice with Plasmodium yoelii, Toxoplasma gondii and vaccinia virus. Mumig, crg-2 and IFN-γ were induced in multiple organs. During the acute phase of each infection, and after intraperitoneal injection of rIFN-γ, levels of Mumig mRNA in the liver were as high or higher than levels in any other organs. In contrast, organs showing the highest expression of crg-2 and IFN-γ varied among the experimental models, with induction of these latter 2 genes colocalizing. Differences in relative levels of expression of Mumig and crg-2 in liver and spleen were not demonstrably due to expression of the genes in different cell types within these organs. It was shown that both Mumig and crg-2 are induced in the liver in hepatocytes and in the spleen in CD11b+ cells. IFN-γ was necessary for induction of Mumig during infections with T. gondii or vaccinia virus. In contrast, induction of crg-2 was not completely dependent on IFN-γ. The results show that, despite the overlap in activities within chemokine subsets, chemokine genes show differences in their patterns of expression and in their responses to inducers that suggest nonredundant roles in vivo. The pattern of induction of crg-2 is consistent with Crg-2 acting primarily locally, whereas the pattern for Mumig induction suggests that MuMig may have a systemic role during infection.
KW  - cytokines
KW  - experimental infections
KW  - gene expression
KW  - genes
KW  - immune response
KW  - interferon
KW  - laboratory animals
KW  - liver
KW  - molecular genetics
KW  - organs
KW  - parasites
KW  - spleen
KW  - viral diseases
KW  - mice
KW  - Plasmodium yoelii
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - biochemical genetics
KW  - immunity reactions
KW  - immunological reactions
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802357&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cutaneous manifestations of human T cell leukemia virus type I infection in an experimental model.
AU  - Simpson, R. M.
AU  - Leno, M.
AU  - Hubbard, B. S.
AU  - Kindt, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 3
SP  - 722
EP  - 726
SN  - 0022-1899
AD  - Simpson, R. M.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
N1  - Accession Number: 19962003995.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref.
KW  - disease models
KW  - experimental infections
KW  - htlv-i infections
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - rabbits
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003995&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis.
AU  - Mahanty, S.
AU  - Mollis, S. N.
AU  - Ravichandran, M.
AU  - Abrams, J. S.
AU  - Kumaraswami, V.
AU  - Jayaraman, K.
AU  - Ottesen, E. A.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 3
SP  - 769
EP  - 773
SN  - 0022-1899
AD  - Mahanty, S.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19960802804.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 130068-27-8.  Subject Subsets: Helminthology; Tropical Diseases
N2  - To determine whether counterregulation by interleukin (IL)-10 plays a role in the generation or maintenance of the antigen-specific hyporesponsiveness seen in asymptomatic microfilaraemic (MF) patients, parasite antigen (PAg)- and nonparasite antigen (NPAg)-driven IL-10 production by peripheral blood mononuclear cells (PBMC) was studied in 10 MF [Wuchereria bancrofti] patients and in 11 patients with chronic lymphatic pathology (CP). PBMC from MF patients spontaneously secreted ~10-fold more IL-10 than did PBMC from patients with CP. PAg also induced significantly more IL-10 production by PBMC from MF than from CP patients. There was a negative correlation between PAg-driven IL-10 production by PBMC and PAg-specific T cell proliferation in the MF group. IL-10 secretion by plastic adherent cells from MF persons was higher in response to PAg than to NPAg, whereas IL-6 and tumour necrosis factor-α secretion were equivalent for PAg and NPAg, suggesting that PAg preferentially induces IL-10 secretion in these cells. Thus, PAg-induced IL-10 likely plays an important role in down-regulating antigen-specific proliferative responses in MF patients.
KW  - antigens
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - interleukin 10
KW  - lymphatic filariasis
KW  - parasites
KW  - man
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802804&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Polymerase chain reaction-based assessment after macrofilaricidal therapy in Onchocerca volvulus infection.
AU  - Nutman, T. B.
AU  - Parredes Y., W.
AU  - Kubofcik, J.
AU  - Guderian, R. H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 3
SP  - 773
EP  - 776
SN  - 0022-1899
AD  - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960802805.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Twenty-eight patients who had skin snips positive for microfilariae (Mf) were studied 120 days after receiving amocarzine, when each was negative for Mf: 16 (57%) were positive for O. volvulus DNA in a PCR-based assay. Of these, 14 (88%) were Mf positive when reassessed parasitologically on day 240, and all were Mf positive on day 365. Equally important was the finding that 12 patients had cleared both Mf and Mf DNA; only 1 was Mf positive at day 240. This suggests that the PCR-based assay provides a sensitive means for assessing infection status after macrofilaricidal chemotherapy and is an early predictor of persons likely to have a recurrence of Mf.
KW  - diagnosis
KW  - drug therapy
KW  - helminths
KW  - human diseases
KW  - molecular biology
KW  - onchocerciasis
KW  - parasites
KW  - polymerase chain reaction
KW  - man
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - amocarzine
KW  - chemotherapy
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - PCR
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802805&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Combination therapy with didanosine and interferon-α in human immunodeficiency virus-infected patients: results of a phase I/II trial.
AU  - Kovacs, J. A.
AU  - Bechtel, C.
AU  - Davey, R. T., Jr.
AU  - Falloon, J.
AU  - Polis, M. A.
AU  - Walker, R. E.
AU  - Metcalf, J. A.
AU  - Davey, V.
AU  - Piscitelli, S. C.
AU  - Baseler, M.
AU  - Dewar, R.
AU  - Salzman, N. P.
AU  - Masur, H.
AU  - Lane, H. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 4
SP  - 840
EP  - 848
SN  - 0022-1899
AD  - Kovacs, J. A.: Critical Care Medicine and Pharmacy Departments, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19962005217.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 69655-05-6, 9008-11-1. 
KW  - antiviral agents
KW  - clinical trials
KW  - combination therapy
KW  - didanosine
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunological deficiency
KW  - immunotherapy
KW  - interferon
KW  - patients
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune deficiency
KW  - immunodeficiency
KW  - multimodal treatment
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005217&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.
AU  - Cohen, O. J.
AU  - Pantaleo, G.
AU  - Holodniy, M.
AU  - Fox, C. H.
AU  - Orenstein, J. M.
AU  - Schnittman, S.
AU  - Niu, M.
AU  - Graziosi, C.
AU  - Pavlakis, G. N.
AU  - Lalezari, J.
AU  - Bartlett, J. A.
AU  - Steigbigel, R. T.
AU  - Cohn, J.
AU  - Novak, R.
AU  - McMahon, D.
AU  - Bilello, J.
AU  - Fauci, A. S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 4
SP  - 849
EP  - 856
SN  - 0022-1899
AD  - Cohen, O. J.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962005218.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 30516-87-1. 
KW  - antiviral agents
KW  - blood
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymph nodes
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005218&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dynamics of virus versus host interaction in children with human immunodeficiency virus type 1 infection.
AU  - Sei, S.
AU  - Akiyoshi, H.
AU  - Bernard, J.
AU  - Venzon, D. J.
AU  - Fox, C. H.
AU  - Schwartzentruber, D. J.
AU  - Anderson, B. D.
AU  - Kopp, J. B.
AU  - Mueller, B. U.
AU  - Pizzo, P. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 6
SP  - 1485
EP  - 1490
SN  - 0022-1899
AD  - Sei, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19962006902.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref.
KW  - blood
KW  - children
KW  - cytokines
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interleukins
KW  - lymphatic system
KW  - replication
KW  - viraemia
KW  - viral load
KW  - viral replication
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - United States of America
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006902&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of a polymerase chain reaction-based assay for diagnosis of Wuchereria bancrofti infection.
AU  - McCarthy, J. S.
AU  - Zhong Min
AU  - Gopinath, R.
AU  - Ottesen, E. A.
AU  - Williams, S. A.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 173
IS  - 6
SP  - 1510
EP  - 1514
SN  - 0022-1899
AD  - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institutes of Health, Bldg. 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970803666.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - To assess the utility of a polymerase chain reaction (PCR)-based method for diagnosis of Wuchereria bancrofti infection, blood, plasma and paraffin-embedded tissue samples from infected and uninfected subjects were tested using a PCR-based assay that detected a W. bancrofti-specific repetitive DNA sequence. The assay was positive in 100 µl of blood from 40 of 42 microfilaria-positive subjects, the 2 subjects with negative assays having microfilarial counts of 1. Samples from 127 uninfected subjects were PCR-negative. The assay was positive in 7 of 10 daytime samples in regions where infection is nocturnally periodic; PCR amplification from paraffin-embedded sections established the diagnosis of W. bancrofti infection in another 2 cases. A microtitre ELISA plate-based method was developed for rapid evaluation of large numbers of samples. The results suggest that this PCR-based assay will be useful in diagnosis of W. bancrofti infection in a variety of clinical settings.
KW  - blood
KW  - blood plasma
KW  - diagnosis
KW  - diagnostic techniques
KW  - ELISA
KW  - evaluation
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - lymphatic filariasis
KW  - microfilariae
KW  - parasites
KW  - polymerase chain reaction
KW  - tissues
KW  - man
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - enzyme linked immunosorbent assay
KW  - nematodes
KW  - parasitic worms
KW  - PCR
KW  - plasma (blood)
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803666&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lamivudine in children with human immunodeficiency virus infection: a phase I/II study.
AU  - Lewis, L. L.
AU  - Venzon, D.
AU  - Church, J.
AU  - Farley, M.
AU  - Wheeler, S.
AU  - Keller, A.
AU  - Rubin, M.
AU  - Yuen, G.
AU  - Mueller, B.
AU  - Sloas, M.
AU  - Wood, L.
AU  - Balis, F.
AU  - Shearer, G. M.
AU  - Brouwers, P.
AU  - Goldsmith, J.
AU  - Pizzo, P. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 1
SP  - 16
EP  - 25
SN  - 0022-1899
AD  - Lewis, L. L.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19962007415.  Publication Type: Journal Article.  Corporate Author: National Cancer Institute Pediatric Branch Human Immunodeficiency Virus Working Group Language: English.  Number of References: 31 ref. Registry Number: 134678-17-4. 
KW  - antiviral agents
KW  - children
KW  - clinical trials
KW  - drug therapy
KW  - efficacy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lamivudine
KW  - pharmacokinetics
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007415&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus.
AU  - Chougnet, C.
AU  - Wynn, T. A.
AU  - Clerici, M.
AU  - Landay, A. L.
AU  - Kessler, H. A.
AU  - Rusnak, J.
AU  - Melcher, G. P.
AU  - Sher, A.
AU  - Shearer, G. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 1
SP  - 46
EP  - 53
SN  - 0022-1899
AD  - Chougnet, C.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1360, USA.
N1  - Accession Number: 19962007418.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
KW  - cytokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - interleukins
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007418&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of immunoreactive tumor necrosis factor-α by a chimeric antibody in patients infected with human immunodeficiency virus type 1.
AU  - Walker, R. E.
AU  - Spooner, K. M.
AU  - Kelly, G.
AU  - McCloskey, R. V.
AU  - Woody, J. N.
AU  - Falloon, J.
AU  - Baseler, M.
AU  - Piscitelli, S. C.
AU  - Davey, R. T., Jr.
AU  - Polis, M. A.
AU  - Kovacs, J. A.
AU  - Masur, H.
AU  - Lane, H. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 1
SP  - 63
EP  - 68
SN  - 0022-1899
AD  - Walker, R. E.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007420.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 308079-78-9. 
KW  - antibodies
KW  - cytokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunosuppression
KW  - tumour necrosis factor
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007420&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Summary of the 31st United States-Japan joint conference on cholera and related diarrheal diseases.
AU  - Lang, D. R.
AU  - Guerrant, R. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 3
SP  - 451
EP  - 455
SN  - 0022-1899
AD  - Lang, D. R.: Enteric Diseases Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19972001030.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - This conference was held at Kiawah Island, South Carolina, USA from 30 November to 3 December 1995. Researchers described substantial advances in cholera epidemiology, detection, molecular mechanisms, and pathophysiology plus new mechanisms for enterotoxigenic, enteroadherent, enterohaemorrhagic and enteroinvasive Escherichia coli. There was also emphasis on new work with and vaccine development with Bacteroides fragilis and Yersinia, Shigella and Salmonella species.
KW  - bacterial diseases
KW  - cholera
KW  - detection
KW  - diagnosis
KW  - diarrhoea
KW  - epidemiology
KW  - human diseases
KW  - pathogenesis
KW  - research
KW  - vaccine development
KW  - bacteroides fragilis
KW  - escherichia coli
KW  - man
KW  - salmonella
KW  - shigella
KW  - vibrio cholerae
KW  - Bacteroides
KW  - Bacteroidaceae
KW  - Bacteroidales
KW  - Bacteroidetes (class)
KW  - Bacteroidetes (phylum)
KW  - Bacteria
KW  - prokaryotes
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - diarrhea
KW  - E. coli
KW  - scouring
KW  - studies
KW  - United States-Japan joint conference on cholera and related diarrheal diseases
KW  - yersinia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for protective immunity to bancroftian filariasis in the Cook Islands.
AU  - Steel, C.
AU  - Guinea, A.
AU  - Ottesen, E. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 3
SP  - 598
EP  - 605
SN  - 0022-1899
AD  - Steel, C.: Laboratory of Parasitic Diseases, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970800694.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti endemic island in the Cook Islands, who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN), were re-examined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation and cytokine [interleukin (IL)-2, IL-5, IL-10, interferon-γ and granulocyte-macrophage colony-stimulating factor] responses in peripheral blood mononuclear cells) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater in the PI/EN group than in a group of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of high- and low-responding individuals who were clinically indistinguishable. The results provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated.
KW  - antibodies
KW  - antigens
KW  - bancroftian filariasis
KW  - blood cells
KW  - colony stimulating factor
KW  - cytokines
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunity
KW  - immunology
KW  - interferon
KW  - interleukin 10
KW  - interleukin 2
KW  - interleukin 5
KW  - interleukins
KW  - lymphatic filariasis
KW  - nematode infections
KW  - parasites
KW  - T lymphocytes
KW  - Cook Islands
KW  - Oceania
KW  - man
KW  - Nematoda
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - Developing Countries
KW  - New Zealand Oceania
KW  - Oceania
KW  - Polynesia
KW  - Pacific Islands
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800694&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiologic determinants of seroreactivity to human papillomavirus (HPV) type 16 virus-like particles in cervical HPV-16 DNA-positive and -negative women.
AU  - Wideroff, L.
AU  - Schiffman, M. H.
AU  - Hoover, R.
AU  - Tarone, R. E.
AU  - Nonnenmacher, B.
AU  - Hubbert, N.
AU  - Kirnbauer, R.
AU  - Greer, C. E.
AU  - Lorincz, A. T.
AU  - Manos, M. M.
AU  - Glass, A. G.
AU  - Scott, D. R.
AU  - Sherman, M. E.
AU  - Buckland, J.
AU  - Lowy, D.
AU  - Schiller, J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 5
SP  - 937
EP  - 943
SN  - 0022-1899
AD  - Wideroff, L.: Epidemiology and Biostatistics Program, Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, USA.
N1  - Accession Number: 19972000790.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Public Health
N2  - The epidemiological determinants of seroreactivity to human papillomavirus (HPV) type 16 L1/L2 virus-like particles (VLPs) were assessed separately in HPV-16 DNA-positive and -negative women participating in a nested case-control study of incident cervical neoplasia in Oregon, USA. 74 women with cervical HPV-16 DNA and 656 cytologically normal HPV-16 DNA-negative subjects were interviewed and tested at 2 time points for viral DNA and once (at the later time) for VLP seroreactivity. Among subjects who were currently HPV-16 DNA-negative, seroreactivity odds ratios increased from 2.9 for 2-5 male sex partners (vs. 0 or 1) to 5.4 for 6-9 partners and 14.0 for ≥10. Thus, prior cervical infection may be a major determinant of seroreactivity in HPV-16 DNA-negative women. This trend was not observed in HPV-16 DNA-positive subjects. Seroreactivity was independently associated with oral contraceptive use, particularly in HPV-16 DNA-negative subjects with use for ≥10 years. Consequently, a possible role for virus-steroid hormone interactions in seroconversion is suggested.
KW  - cervix
KW  - epidemiology
KW  - human diseases
KW  - immune response
KW  - seroprevalence
KW  - viral diseases
KW  - virus-like particles
KW  - women
KW  - North America
KW  - Oregon
KW  - USA
KW  - human papillomavirus 16
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Papillomaviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - human papillomavirus
KW  - immunity reactions
KW  - immunological reactions
KW  - Papovaviridae
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000790&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of human immunodeficiency virus (HIV) type 1 RNA levels in cerebrospinal fluid and viral resistance to zidovudine in children with HIV encephalopathy.
AU  - Sei, S.
AU  - Stewart, S. K.
AU  - Farley, M.
AU  - Mueller, B. U.
AU  - Lane, J. R.
AU  - Robb, M. L.
AU  - Brouwers, P.
AU  - Pizzo, P. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 6
SP  - 1200
EP  - 1206
SN  - 0022-1899
AD  - Sei, S.: Pediatric Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19972001575.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 63231-63-0, 30516-87-1. 
N2  - The amount of HIV-1 RNA and presence of the mutation conferring viral resistance to zidovudine were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children with or without encephalopathy. The presence of zidovudine-resistant HIV-1 in CSF affecting the neurological outcome during treatment with zidovudine was also examined. The level of HIV-1 RNA in CSF was highest in children with severe encephalopathy (n=25; median, 430 copies/ml; range 0-22 × 105 copies/ml) followed by the moderately encephalopathic (n=7; median, 330; range 0-1130) and non-encephalopathic groups (n=9; median, 0; range, 0-566) (P=0.007). There was no correlation between CSF and plasma HIV-1 RNA levels. Five of 7 children with wild type codon 215 had improved or stable disease during zidovudine treatment (P=0.007). It is suggested that increased viral replication and emergence of drug-resistant HIV-1 variants within the central nervous system may play a role in progression of HIV encephalopathy.
KW  - antiviral agents
KW  - blood plasma
KW  - body parts
KW  - central nervous system
KW  - cerebrospinal fluid
KW  - children
KW  - clinical aspects
KW  - disease course
KW  - drug resistance
KW  - drug therapy
KW  - encephalopathy
KW  - evaluation
KW  - human immunodeficiency viruses
KW  - mutations
KW  - nervous system
KW  - replication
KW  - resistance
KW  - rna
KW  - treatment
KW  - viral replication
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - chemotherapy
KW  - clinical picture
KW  - CNS
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - plasma (blood)
KW  - ribonucleic acid
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001575&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Perspective: prospects for development of vaccines against human helminth infections.
AU  - McCarthy, J. S.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1996///
VL  - 174
IS  - 6
SP  - 1384
EP  - 1390
SN  - 0022-1899
AD  - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970805828.  Publication Type: Journal Article.  Language: English.  Number of References: 89 ref. Subject Subsets: Helminthology
N2  - The prospects for the development of vaccines against human helminth infections are discussed under the following headings: strategies for disease control; naturally acquired human immunity; immune effector mechanisms in human helminth infection; animal models of immunity in helminth infections; strategies to identify helminth antigens as possible vaccine targets; progress towards the development of helminth vaccines; and other approaches to vaccine development.
KW  - helminths
KW  - human diseases
KW  - immunity
KW  - parasites
KW  - vaccination
KW  - vaccine development
KW  - vaccines
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - general account
KW  - parasitic worms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805828&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31.
AU  - Stevenson, B.
AU  - Tilly, K.
AU  - Rosa, P. A.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1996///
VL  - 178
IS  - 12
SP  - 3508
EP  - 3516
SN  - 0021-9193
AD  - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19960505123.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 9007-49-2.  Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2  - The authors identified 4 loci in B. burgdorferi B31 that contain open reading frames capable of encoding 6 proteins that are related to the antigenic proteins OspE and OspF. These proteins were designated Erp, for OspEF-related protein, and their respective genes named erp. The erpA and erpB genes are linked, as are erpC and erpD, and the pairs probably constitute 2 operons. The erpG and erpH genes appear to be monocistronic. The ErpA and ErpC proteins are expressed by B. burgdorferi B31 in culture and are recognized by a polyclonal antiserum raised against the OspE protein of B. burgdorferi N40. The 4 erp loci are each located on different 32-kb circular plasmids that contain additional DNA sequences that are homologous to each other and to an 8.3-kb circular plasmid of B. burgdorferi s.l. Ip21. All four 32-kb plasmids can be maintained within a single bacterium, which may provide a model for the study of plasmid replication and segregation in B. burgdorferi.
KW  - amino acid sequences
KW  - antigens
KW  - DNA
KW  - genes
KW  - nucleotide sequences
KW  - open reading frames
KW  - plasmids
KW  - proteins
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - immunogens
KW  - ORFs
KW  - outer surface proteins
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960505123&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A developmental stage-specific histone H1 homolog of Coxiella burnetii.
AU  - Heinzen, R. A.
AU  - Hackstadt, T.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1996///
VL  - 178
IS  - 16
SP  - 5049
EP  - 5052
SN  - 0021-9193
AD  - Heinzen, R. A.: Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19970501301.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9007-49-2.  Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2  - Two DNA-binding proteins were detected in C. burnetii by Southwestern (DNA-protein) blotting. One of these, termed Hq1, is enriched in the small cell variant stage of the developmental cycle and displays compositional and primary amino acid sequence similarities to eukaryotic histone H1. C. burnetii appears to be another example of an intracellular parasite with morphologically distinct developmental forms whose nucleoid structure may be controlled by histone H1 homologues.
KW  - amino acid sequences
KW  - binding proteins
KW  - clones
KW  - DNA
KW  - histones
KW  - molecular genetics
KW  - nucleotide sequences
KW  - Coxiella
KW  - Coxiella burnetii
KW  - Coxiellaceae
KW  - Legionellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Coxiella
KW  - bacterium
KW  - biochemical genetics
KW  - carrier proteins
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - Hq1
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501301&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi.
AU  - Rosa, P.
AU  - Samuels, D. S.
AU  - Hogan, D.
AU  - Stevenson, B.
AU  - Casjens, S.
AU  - Tilly, K.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1996///
VL  - 178
IS  - 20
SP  - 5946
EP  - 5953
SN  - 0021-9193
AD  - Rosa, P.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19970501820.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 4434-05-3, 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - The authors investigated gene inactivation by allelic exchange using a mutated borrelial gyrB gene that confers resistance to the antibiotic coumermycin A1 as a selectable marker. B. burgdorferi was transformed by electroporation with a linear fragment of DNA in which this selectable marker was flanked by sequences from a native borrelial 26-kb circular plasmid. Coumermycin A1-resistant transformants were identified in which gyrB had interrupted the targeted site on the 26-kb plasmid via homologous recombination with the flanking sequences. Antibiotic resistance conferred by the mutated gyrB gene on the plasmid was dominant, and transformed spirochaetes carrying this plasmid did not contain any unaltered copies of the plasmid. Coumermycin A1 resistance can be transferred to naive B. burgdorferi by transformation with borrelial plasmid DNA from the initial transformants. This work represents the first example of a directed mutation in B. burgdorferi whereby a large segment of heterologous DNA (gyrB) has been inserted via homologous recombination with flanking sequences, thus demonstrating the feasibility of specific gene inactivation by allelic exchange.
KW  - antibiotics
KW  - biotechnology
KW  - coumamycin
KW  - DNA
KW  - electroporation
KW  - genes
KW  - genetic engineering
KW  - genetic markers
KW  - mutations
KW  - plasmids
KW  - recombination
KW  - resistance
KW  - targeted mutagenesis
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - coumermycin
KW  - deoxyribonucleic acid
KW  - gene inactivation
KW  - genetic manipulation
KW  - genetic recombination
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501820&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.
AU  - Carrera, L.
AU  - Gazzinelli, R. T.
AU  - Badolato, R.
AU  - Hieny, S.
AU  - Müller, W.
AU  - Kühn, R.
AU  - Sacks, D. L.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1996///
VL  - 183
IS  - 2
SP  - 515
EP  - 526
SN  - 0022-1007
AD  - Carrera, L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19960803507.  Publication Type: Journal Article.  Language: English.  Number of References: 66 ref. Registry Number: 9008-11-1, 308079-78-9.  Subject Subsets: Protozoology; Tropical Diseases
N2  - Leishmania major promastigotes were found to avoid activation of mouse bone marrow-derived macrophages (BMMø) in vitro for production of cytokines that are typically induced during infection with other intracellular pathogens. Coexposure of BMMø to L. major and other microbial stimuli resulted in complete inhibition of interleukin (IL)-12(p40) mRNA induction and IL-12 release. In contrast, mRNA and protein levels for IL-1α, IL-1β, tumour necrosis factor (TNF)-α and inducible NO synthase (iNOS) were only partially reduced, and signals for IL-10 and monocyte chemoattractant protein (MCP-1/JE) were enhanced. L. major provided a detectable trigger for TNF-α and iNOS in BMMø primed with interferon (IFN)-γ but still failed to induce IL-12. Thus IL-12 induction was selectively impaired after infection, whereas activation pathways for other monokine responses remained relatively intact. Selective and complete inhibition of IL-12(p40) induction was observed using BMMø from either genetically susceptible or resistant mouse strains, as well as IL-10 knockout mice, and was obtained using promastigotes from cutaneous, visceral and lipophosphoglycan-deficient strains of L. major and L. donovani. The impaired production of the major physiological inducer of IFN-γ may underlie the relatively prolonged interval of parasite intracellular survival and replication that is typically associated with leishmanial infections, including those producing self-limiting disease.
KW  - bone marrow
KW  - cytokines
KW  - immune response
KW  - in vitro
KW  - interferon
KW  - interleukin 1
KW  - interleukin 12
KW  - interleukins
KW  - lymphokines
KW  - macrophages
KW  - messenger rna
KW  - monokines
KW  - parasites
KW  - promastigotes
KW  - tumour necrosis factor
KW  - Leishmania donovani
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - cachectin
KW  - cachexin
KW  - immunity reactions
KW  - immunological reactions
KW  - mRNA
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803507&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The efficiency of acute infection of CD4+ T cells is markedly enhanced in the setting of antigen-specific immune activation.
AU  - Weissman, D.
AU  - Barker, T. D.
AU  - Fauci, A. S.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1996///
VL  - 183
IS  - 2
SP  - 687
EP  - 692
SN  - 0022-1007
AD  - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962005167.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
KW  - antigens
KW  - CD4+ lymphocytes
KW  - dendritic cells
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - CD4+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005167&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression of variants of the major surface glycoprotein of Pneumocystis carinii.
AU  - Angus, C. W.
AU  - Tu, A.
AU  - Vogel, P.
AU  - Qin, M.
AU  - Kovacs, J. A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1996///
VL  - 183
IS  - 3
SP  - 1229
EP  - 1234
SN  - 0022-1007
AD  - Angus, C. W.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961201213.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A multicopy family of related but unique genes encodes the major surface glycoprotein (MSG) of P. carinii. To examine whether different members of this gene family are expressed by P. carinii, antisera were prepared against peptides whose sequences were determined from the deduced amino acid sequences of variants of rat-derived MSG. Immunohistochemical staining of serial sections of lungs of infected rats showed that at least 3 variants of MSG were expressed in an individual lobe, that there was a focal expression of these variants within the lung, and that the relative numbers of these foci were different. Indirect immunofluorescent staining of purified P. carinii using these antisera revealed that at least 3 variants of MSG were present in organisms isolated from an individual rat and that both cysts and trophozoites reacted with each antiserum. A substantial difference in the fraction of organisms reacting with a specific antipeptide antiserum was seen when comparing organisms isolated from rats raised in a single colony over a period of 2 yr as well as organisms isolated at one time point from rats raised in different colonies. It is suggested that P. carinii utilizes antigenic variation for evading host defense mechanisms.
KW  - antigens
KW  - gene expression
KW  - genes
KW  - glycoproteins
KW  - immunology
KW  - infections
KW  - mycoses
KW  - pneumocystosis
KW  - fungi
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - rats
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - antigenicity
KW  - fungus
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201213&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection of human immunodeficiency virus 1 transgenic mice with Toxoplasma gondii stimulates proviral transcription in macrophages in vivo.
AU  - Gazzinelli, R. T.
AU  - Sher, A.
AU  - Cheever, A.
AU  - Gerstberger, S.
AU  - Martin, M. A.
AU  - Dickie, P.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1996///
VL  - 183
IS  - 4
SP  - 1645
EP  - 1655
SN  - 0022-1007
AD  - Gazzinelli, R. T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970800447.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 9007-49-2, 63231-63-0.  Subject Subsets: Protozoology
N2  - Human immunodeficiency virus (HIV)-1 transgenic mice expressing low or undetectable levels of viral mRNA in lymphoid tissue were each infected with 20 cysts of Toxoplasma gondii (avirulent strain ME-49). Exposure to the parasite resulted in an increase in HIV-1 transcripts in lymph nodes, spleen and lungs during the acute phase of infection and in the central nervous system during the chronic stage of disease. In vivo and ex vivo experiments identified macrophages as a major source of the induced HIV-1 transcripts. In contrast, T. gondii infection failed to stimulate HIV-1 transcription in tissues of 2 HIV-1 transgenic mouse strains harbouring a HIV-1 proviral DNA in which the nuclear factor (NF)-κB binding motifs from the viral long terminal repeats had been replaced with a duplicated Moloney murine leukaemia virus core enhancer. A role for NF-κB in the activation of HIV-1 by T. gondii was also suggested by the simultaneous induction of NF-κB binding activity and tumour necrosis factor-α synthesis in transgenic mouse macrophages stimulated by exposure to parasite extracts. The results demonstrate the potential of an opportunistic pathogen to induce HIV-1 transcription in vivo and suggest a mechanism for the dissemination of HIV-1 by macrophages.
KW  - acute course
KW  - central nervous system
KW  - chronic course
KW  - DNA
KW  - experimental infections
KW  - host parasite relationships
KW  - human immunodeficiency viruses
KW  - laboratory animals
KW  - lungs
KW  - lymph nodes
KW  - macrophages
KW  - molecular genetics
KW  - opportunistic infections
KW  - parasites
KW  - RNA
KW  - spleen
KW  - transcription
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - biochemical genetics
KW  - CNS
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - parasite host relationships
KW  - ribonucleic acid
KW  - severe course
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800447&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects.
AU  - Marzo Veronese, F. di
AU  - Arnott, D.
AU  - Barnaba, V.
AU  - Loftus, D. J.
AU  - Sakaguchi, K.
AU  - Thompson, C. B.
AU  - Salemi, S.
AU  - Mastroianni, C.
AU  - Sette, A.
AU  - Shabanowitz, J.
AU  - Hunt, D. F.
AU  - Appella, E.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1996///
VL  - 183
IS  - 6
SP  - 2509
EP  - 2516
SN  - 0022-1007
AD  - Marzo Veronese, F. di: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006311.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref.
KW  - cytotoxic T lymphocytes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - peptides
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - vinculin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006311&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The domain on the duffy blood group antigen for binding Plasmodium vivax and P. knowlesi malarial parasites to erythrocytes.
AU  - Chitnis, C. E.
AU  - Chaudhuri, A.
AU  - Horuk, R.
AU  - Pogo, A. O.
AU  - Miller, L. H.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1996///
VL  - 184
IS  - 4
SP  - 1531
EP  - 1536
SN  - 0022-1007
AD  - Chitnis, C. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19970800395.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - Plasmodium vivax and P. knowlesi use the Duffy blood group antigen as a receptor to invade human erythrocytes and region II of the parasite ligands for binding to this erythrocyte receptor. The peptide within the Duffy blood group antigen of human and rhesus erythrocytes to which the P. vivax and P. knowlesi ligands bind was identified. Peptides from the NH2-terminal extracellular region of the Duffy antigen were tested for their ability to block the binding of erythrocytes to transfected Cos cells expressing on their surface region II of the Duffy-binding ligands. The binding site on the human Duffy antigen used by both the P. vivax and P. knowlesi ligands mapped to a 35-amino acid region. A 34-amino acid peptide from the equivalent region of the rhesus Duffy antigen blocked the binding of P. vivax to human erythrocytes, although the P. vivax ligand expressed on Cos cells did not bind rhesus erythrocytes. The binding of the rhesus peptide, but not the rhesus erythrocyte, to the P. vivax ligand was explained by interference of carbohydrate with the binding process. Rhesus erythrocytes, treated with N-glycanase, bound specifically to P. vivax region II. Thus, the interaction of P. vivax ligand with human and rhesus erythrocytes appears to be mediated by a peptide-peptide interaction. Glycosylation of the rhesus Duffy antigen appears to block binding of the P. vivax ligand to rhesus erythrocytes.
KW  - amino acid sequences
KW  - antigens
KW  - binding
KW  - blood
KW  - blood group antigens
KW  - cell cultures
KW  - cell invasion
KW  - erythrocyte invasion
KW  - erythrocytes
KW  - host parasite relationships
KW  - in vitro
KW  - ligands
KW  - parasites
KW  - peptides
KW  - receptors
KW  - Macaca mulatta
KW  - man
KW  - Plasmodium knowlesi
KW  - Plasmodium vivax
KW  - protozoa
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - antigenicity
KW  - blood red cells
KW  - immunogens
KW  - parasite host relationships
KW  - protein sequences
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800395&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic variants of human T-lymphotropic virus type II in American Indian groups.
AU  - Biggar, R. J.
AU  - Taylor, M. E.
AU  - Neel, J. V.
AU  - Hjelle, B.
AU  - Levine, P. H.
AU  - Black, F. L.
AU  - Shaw, G. M.
AU  - Sharp, P. M.
AU  - Hahn, B. H.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1996///
VL  - 216
IS  - 1
SP  - 165
EP  - 173
SN  - 0042-6822
AD  - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19962008118.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
KW  - epidemiology
KW  - ethnic groups
KW  - genetic variation
KW  - HTLV-II infections
KW  - human diseases
KW  - nucleotide sequences
KW  - phylogenetics
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type ii
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - DNA sequences
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008118&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs.
AU  - Semmes, O. J.
AU  - Majone, F.
AU  - Cantemir, C.
AU  - Turchetto, L.
AU  - Hjelle, B.
AU  - Jeang KuanTeh
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1996///
VL  - 217
IS  - 1
SP  - 373
EP  - 379
SN  - 0042-6822
AD  - Semmes, O. J.: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962008959.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
KW  - genomes
KW  - HTLV infections
KW  - human diseases
KW  - pathogenesis
KW  - Tax protein
KW  - transcription
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - human t-cell lymphotropic virus type ii
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - long terminal repeat
KW  - micronuclei
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008959&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues.
AU  - Delahunty, M. D.
AU  - Rhee, I.
AU  - Freed, E. O.
AU  - Bonifacino, J. S.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1996///
VL  - 218
IS  - 1
SP  - 94
EP  - 102
SN  - 0042-6822
AD  - Delahunty, M. D.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19962007007.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref.
KW  - amino acid sequences
KW  - envelope protein gp41
KW  - HIV-1 infections
KW  - human diseases
KW  - mutations
KW  - pathogenesis
KW  - syncytia
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - gp41
KW  - human immunodeficiency virus type 1
KW  - membrane fusion
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma.
AU  - Morton, R. L.
AU  - David, H.
AU  - O'Connor, P. M.
AU  - Bustin, M.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1996///
VL  - 222
IS  - 2
SP  - 368
EP  - 373
SN  - 0006-291X
AD  - Morton, R. L.: National Cancer Institute, National Institutes of Health, Bethesda MD 20852, USA.
N1  - Accession Number: 19992005600.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref.
KW  - Burkitt's lymphoma
KW  - cell cycle
KW  - human diseases
KW  - lymphoma
KW  - protein synthesis
KW  - proteins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - protein biosynthesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005600&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human fetal glial cells constitutively produce HIV-inducing cytokines.
AU  - Kalebic, T.
JO  - Experimental Cell Research
JF  - Experimental Cell Research
Y1  - 1996///
VL  - 223
IS  - 2
SP  - 452
EP  - 458
SN  - 0014-4827
AD  - Kalebic, T.: Laboratory of Molecular Oncology, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962009313.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9068-38-6. 
KW  - antibodies
KW  - antigens
KW  - cell lines
KW  - cytokines
KW  - fetus
KW  - human immunodeficiency viruses
KW  - neuroglia
KW  - reverse transcriptase
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenicity
KW  - foetus
KW  - glial cells
KW  - human immunodeficiency virus
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009313&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression of CD26 does not correlate with the replication of macrophage-tropic strains of HIV-1 in T-cell lines.
AU  - Watkins, B. A.
AU  - Crowley, R. W.
AU  - Davis, A. E.
AU  - Louie, A. T.
AU  - Reitz, M. S., Jr.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1996///
VL  - 224
IS  - 1
SP  - 276
EP  - 280
SN  - 0042-6822
AD  - Watkins, B. A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.
N1  - Accession Number: 19972002669.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref.
KW  - CD4+ lymphocytes
KW  - human diseases
KW  - macrophages
KW  - proteinases
KW  - replication
KW  - strains
KW  - surface antigens
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4+ cells
KW  - human immunodeficiency virus type 1
KW  - proteases
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002669&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutational analysis of a neutralization epitope on the dengue type 2 virus (DEN2) envelope protein: monoclonal antibody resistant DEN2/DEN4 chimeras exhibit reduced mouse neurovirulence.
AU  - Hiramatsu, K.
AU  - Tadano, M.
AU  - Men, R.
AU  - Lai ChingJuh
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1996///
VL  - 224
IS  - 2
SP  - 437
EP  - 445
SN  - 0042-6822
AD  - Hiramatsu, K.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970501469.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - amino acids
KW  - analysis
KW  - arboviruses
KW  - envelope proteins
KW  - epitopes
KW  - monoclonal antibodies
KW  - mutations
KW  - neutralization
KW  - viral proteins
KW  - viral structural proteins
KW  - virulence
KW  - dengue 2 virus
KW  - dengue 4 virus
KW  - dengue virus
KW  - mice
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - arthropod-borne viruses
KW  - neurovirulence
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501469&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein.
AU  - Portis, J. L.
AU  - Fujisawa, R.
AU  - McAtee, F. J.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1996///
VL  - 226
IS  - 2
SP  - 384
EP  - 392
SN  - 0042-6822
AD  - Portis, J. L.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19972001576.  Publication Type: Journal Article.  Language: English. 
KW  - central nervous system
KW  - gag protein
KW  - microbiology
KW  - mutants
KW  - pathogenesis
KW  - proteins
KW  - structural genes
KW  - retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CNS
KW  - MuLV
KW  - other Retroviridae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001576&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunological detection of CYP2E1 in fresh rat lymphocytes and its pretranslational induction by fasting.
AU  - Soh YunJo
AU  - Rhee, H. M.
AU  - Sohn DongHwan
AU  - Song, B. J.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1996///
VL  - 227
IS  - 2
SP  - 541
EP  - 546
SN  - 0006-291X
AD  - Soh YunJo: Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland 20852, USA.
N1  - Accession Number: 19991409706.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9035-51-2, 64-17-5.  Subject Subsets: Human Nutrition
KW  - cytochrome P-450
KW  - ethanol
KW  - fasting
KW  - induction
KW  - lymphocytes
KW  - messenger RNA
KW  - regulation
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ethyl alcohol
KW  - mRNA
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409706&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Monitoring cleavage of fusion proteins by matrix-assisted laser desorption ionization/mass spectrometry: recombinant HIV-1IIIB p26.
AU  - Parker, C. E.
AU  - Papac, D. I.
AU  - Tomer, K. B.
JO  - Analytical Biochemistry
JF  - Analytical Biochemistry
Y1  - 1996///
VL  - 239
IS  - 1
SP  - 25
EP  - 34
SN  - 0003-2697
AD  - Parker, C. E.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19972001092.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref.
KW  - enzymology
KW  - fusion proteins
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - laboratory methods
KW  - mass spectrometry
KW  - monitoring
KW  - proteins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - laboratory techniques
KW  - surveillance systems
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001092&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gender differences in muscle sympathetic nerve activity: effect of body fat distribution.
AU  - Jones, P. P.
AU  - Snitker, S.
AU  - Skinner, J. S.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1996///
VL  - 270
IS  - 2
SP  - E363
EP  - E366
SN  - 0002-9513
AD  - Jones, P. P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19961404131.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Human Nutrition
N2  - Microneurography, hydrodensitometry and waist-to-hip ratio (W/T) measures were obtained in 14 men (24±2 years old) and 14 women (27±3 years old) with a large range of percent body fat (%BF) and W/T. Regression analyses revealed positive correlations between muscle sympathetic nerve activity (MSNA) and %BF in men (r = 0.55, P=0.04) and in women (r = 0.63, P=0.02), with no difference in the slopes of the regression lines but a higher intercept in men (P&lt;0.01). When genders were pooled, MSNA and W/T were correlated (r = 0.68, P&lt;0.0001); this positive correlation was also found in men (r = 0.57, P=0.04) but not as strongly in women (r = 0.49, P=0.07). Forward stepwise multiple-regression analysis using %BF, W/T, gender and age indicated that W/T was the primary factor related to MSNA (R² = 0.46); the other factors were not independent predictors. It is concluded that %BF is related to MSNA in both sexes but that the regression line is shifted downward in women because of lower levels of MSNA. W/T is a better correlate of MSNA than %BF and partially explains the higher MSNA in men. The findings may be relevant to the cardiovascular and metabolic disease risk associated with abdominal obesity.
KW  - body composition
KW  - body fat
KW  - distribution
KW  - muscles
KW  - sex differences
KW  - sympathetic nervous system
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404131&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin.
AU  - Otteken, A.
AU  - Moss, B.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 1
SP  - 97
EP  - 103
SN  - 0021-9258
AD  - Otteken, A.: Laboratory of Viral Disease, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002904.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref.
KW  - acquired immune deficiency syndrome
KW  - binding
KW  - envelope proteins
KW  - HIV infections
KW  - human diseases
KW  - molecular biology
KW  - proteins
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - calnexin
KW  - calreticulin
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002904&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cataractogenesis in transgenic mice containing the HIV-1 protease linked to the lens αA-crystallin promoter.
AU  - Tumminia, S. J.
AU  - Jonak, G. J.
AU  - Focht, R. J.
AU  - Cheng, Y. S. E.
AU  - Russell, P.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 1
SP  - 425
EP  - 431
SN  - 0021-9258
AD  - Tumminia, S. J.: Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002905.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
KW  - cataract
KW  - eye diseases
KW  - eye lens
KW  - genetically engineered organisms
KW  - human diseases
KW  - pathogenesis
KW  - proteinases
KW  - transgenic animals
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GMOs
KW  - HIV-1/HIV infections
KW  - proteases
KW  - transgenic organisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002905&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of glucocorticoids on energy metabolism and food intake in humans.
AU  - Tataranni, P. A.
AU  - Larson, D. E.
AU  - Snitker, S.
AU  - Young, J. B.
AU  - Flatt, J. P.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1996///
VL  - 271
IS  - 2
SP  - E317
EP  - E325
SN  - 0002-9513
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19961410170.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 50-24-8, 5060-55-9, 52-21-1, 51-40-1, 630-67-1, 1107-99-9, 69815-49-2, 125-02-0, 51-41-2.  Subject Subsets: Human Nutrition
N2  - The effect of glucocorticoid administration on energy metabolism and food intake was studied in 20 healthy, nondiabetic Caucasian male subjects (27±5 (SD) years old, 72±9 kg, 20±7% body fat) randomly and blindly assigned to glucocorticoid (methylprednisolone, METH; n=10) or placebo (PLAC; n=10) treatment. Each subject was studied twice: during a weight maintenance diet and during ad libitum food intake. Energy metabolism was measured by indirect calorimetry and food intake by an automated food-selection system. 24-h urinary norepinephrine excretion (24-h NE) was used as an estimate of sympathetic nervous system activity. During weight maintenance, METH intravenous infusion (125 mg/30 min) increased energy expenditure compared with PLAC, and after 4 days of oral therapy, METH (40 mg/day) decreased 24-h NE and increased energy expenditure compared with PLAC. During ad libitum food intake, after 4 days of METH (40 mg/day) or PLAC oral therapy, both groups increased their energy intake over weight maintenance, but the increase was larger in the METH group than the PLAC group (4554±1857 vs. 2867±846 kcal/day; P=0.04). The data suggest that therapeutic doses of glucocorticoids induce obesity mostly by increasing energy intake, an effect which may be related to the ability of glucocorticoids to act directly or indirectly on the central regulation of appetite.
KW  - appetite
KW  - calorimetry
KW  - energy intake
KW  - energy metabolism
KW  - excretion
KW  - food intake
KW  - glucocorticoids
KW  - norepinephrine
KW  - obesity
KW  - prednisolone
KW  - sympathetic nervous system
KW  - urine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorimetric methods
KW  - fatness
KW  - noradrenaline
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410170&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation.
AU  - Wondrak, E. M.
AU  - Nashed, N. T.
AU  - Haber, M. T.
AU  - Jerina, D. M.
AU  - Louis, J. M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 8
SP  - 4477
EP  - 4481
SN  - 0021-9258
AD  - Wondrak, E. M.: Molecular Mechanisms of Development Section, Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962005597.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - precursors
KW  - proteinases
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005597&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 protein expression from synthetic circles of DNA mimicking the extrachromosomal forms of viral DNA.
AU  - Cara, A.
AU  - Cereseto, A.
AU  - Lori, F.
AU  - Reitz, M. S., Jr.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 10
SP  - 5393
EP  - 5397
SN  - 0021-9258
AD  - Cara, A.: Laboratory of Tumor Cell Biology, NCI, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19962005774.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - genes
KW  - HIV-1 infections
KW  - human immunodeficiency viruses
KW  - proteins
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005774&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter.
AU  - Yang NengYu
AU  - Shigeta, H.
AU  - Shi HuiPing
AU  - Teng, C. T.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 10
SP  - 5795
EP  - 5804
SN  - 0021-9258
AD  - Yang NengYu: Gene Regulation Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
N1  - Accession Number: 19960402852.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Registry Number: 9007-49-2, 339615-76-8.  Subject Subsets: Dairy Science
N2  - A DNA sequence (-418 to -378, FP1), upstream from the imperfect oestrogen response element (ERE) at the 5′-flanking region of the human lactoferrin gene in RL95-2 endometrium carcinoma cells was examined. Electrophoresis mobility shift assay, site-directed mutagenesis and DNA methylation interference analyses were used. The nuclear protein binding elements in the FP1 region were mapped. Three nuclear proteins bound to the FP1 region (C1, C2 and C3 sites). The nuclear receptor, chicken ovalbumin upstream promoter-transcription factor, bound to the C2 site. Mutations in the C1 binding region abolished C1 complex formation and reduced oestrogen-dependent transcription from the lactoferrin ERE. When the imperfect ERE of the lactoferrin gene was converted to a perfect palindromic structure, the enhancing effect of the C1 binding element for oestrogen responsiveness was abolished. A complementary DNA (cDNA) clone was isolated from an RL95-2 expression library encoding the C1 site-binding protein. The encoded polypeptide maintained 99% amino acid identity with a previously described orphan nuclear oestrogen-related receptor (hERR1). A 2.2-kb messenger RNA was detected in RL95-2 cells by the newly isolated cDNA but not by the first 180 bp of the published hERR1 sequence. By Western analysis, a major 42-kDa protein was detected in the RL95-2 nuclear extract with antibody generated against glutathione S-transferase-hERR1 fusion protein. hERR1 interacted with the human oestrogen receptor through protein-protein contacts. The nucleotide sequences reported were submitted to the GenBank/EMBL Data Bank with accession number L38487 (Genome Sequence Data Base).
KW  - binding
KW  - cell culture
KW  - cells
KW  - complementary dna
KW  - dna
KW  - endometrium
KW  - gene expression
KW  - hormonal control
KW  - lactoferrin
KW  - neoplasms
KW  - nucleic acids
KW  - nucleotide sequences
KW  - oestrogen receptors
KW  - oestrogens
KW  - promoters
KW  - receptors
KW  - regulators
KW  - transcription
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cDNA
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - DNA transcription
KW  - endocrine control
KW  - endometrial area
KW  - estrogen receptors
KW  - estrogens
KW  - governors
KW  - hormonal regulation
KW  - promoter region
KW  - promoter sequences
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960402852&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A soluble active mutant of HIV-1 integrase. Involvement of both the core and carboxyl-terminal domains in multimerization.
AU  - Jenkins, T. M.
AU  - Engelman, A.
AU  - Ghirlando, R.
AU  - Craigie, R.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 13
SP  - 7712
EP  - 7718
SN  - 0021-9258
AD  - Jenkins, T. M.: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-0560, USA.
N1  - Accession Number: 19962006807.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref.
KW  - HIV-1 infections
KW  - human diseases
KW  - mutations
KW  - solubility
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006807&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell leukemia virus type I Tax masks c-Myc function through a cAMP-dependent pathway.
AU  - Semmes, O. J.
AU  - Barrett, J. F.
AU  - Dang, C. V.
AU  - Jeang KuanTeh
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 16
SP  - 9730
EP  - 9738
SN  - 0021-9258
AD  - Semmes, O. J.: Laboratory of Molecular Microbiology, Molecular Virology Section, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962006198.  Publication Type: Journal Article.  Language: English.  Number of References: 95 ref. Registry Number: 60-92-4. 
KW  - c-amp
KW  - genes
KW  - htlv infections
KW  - human diseases
KW  - mutants
KW  - regulatory genes
KW  - tax gene
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus
KW  - retroviridae
KW  - Deltaretrovirus
KW  - viruses
KW  - RNA Reverse Transcribing Viruses
KW  - Retroviridae
KW  - cyclic adenosine monophosphate
KW  - cyclic AMP
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006198&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells.
AU  - Baier, L. J.
AU  - Bogardus, C.
AU  - Sacchettini, J. C.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 18
SP  - 10892
EP  - 10896
SN  - 0021-9258
AD  - Baier, L. J.: NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19961408733.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - A polymorphism in the gene that encodes human intestinal fatty acid binding protein (IFABP) results in an alanine (Ala54) to threonine (Thr54) substitution at codon 54 that alters the in vitro binding affinity of the protein for long-chain fatty acids. To identify potential functional variability between Ala54 and Thr54 IFABP, permanently transfected Caco-2 cell lines that express either Ala54 or Thr54 IFABP were established. Caco-2 cells that expressed Thr54 IFABP transported long-chain fatty acids and secreted triglycerides to a greater degree than Caco-2 cells expressing Ala54 IFABP. It was concluded that IFABP participates in the intracellular transport of long-chain fatty acids. In addition, the observed increase in transport of fatty acids across cells expressing Thr54 IFABP suggests a plausible physiological mechanism for the observation that Pima Indians with a Thr54 IFABP genotype have increased post-absorptive lipid oxidation rates and are more insulin-resistant than Pima Indians with a Ala54 IFABP genotype.
KW  - binding proteins
KW  - cell cultures
KW  - cell lines
KW  - fatty acids
KW  - genetic polymorphism
KW  - insulin
KW  - lipid metabolism
KW  - long chain fatty acids
KW  - mutants
KW  - resistance
KW  - secretion
KW  - transport
KW  - triacylglycerols
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - fat metabolism
KW  - transportation
KW  - triglycerides
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408733&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A synthetic conformational epitope from the C4 domain of HIV Gp120 that binds CD4.
AU  - Robey, F. A.
AU  - Harris-Kelson, T.
AU  - Robert-Guroff, M.
AU  - Batinic´, D.
AU  - Ivanov, B.
AU  - Lewis, M. S.
AU  - Roller, P. P.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 30
SP  - 17990
EP  - 17995
SN  - 0021-9258
AD  - Robey, F. A.: Peptide and Immunochemistry Unit, NIDR, National Institutes of Health Bethesda, Maryland 20892.
N1  - Accession Number: 19982002231.  Publication Type: Journal Article.  Language: English. 
N2  - The fourth conserved domain of the human immunodeficiency virus type 1 (HIV-1) envelope, the C4 region of glycoprotein 120 (gp120), is believed to be a major part of gp120 that is necessary for binding to CD4. Recently, we found that C4 in gp120 is probably an α-helix, because antibodies made against helical constructs of C4 react with native and recombinant gp120 but antibodies against linear C4 constructs do not. For the present study, we performed experiments to determine, first, if CD4 could bind to the helical C4 constructs and, second, if the binding was comparable with CD4 binding to gp120. Immobilized helical constructs derived from the C4s from HIV-1 and HIV-2 bound biotinylated recombinant CD4 with Kd values of 8.59 nM and 14.59 n, respectively. Recombinant soluble CD4 inhibited the binding of biotinylated CD4 to the C4 construct from HIV-1 with a Kd of 9.88 n, and recombinant gp120 blocked the binding of CD4 to the immobilized helical construct from C4 of HIV-1 with a Kd of 8.08 n. The C4 peptide-(419-436) from HIV-1 (KIKQIINMWQEVGKAMYA-NH2) blocked CD4 binding to gp120 but only in a buffer containing 0.03% Brij 35 where the peptide displayed 17 ± 1% α-helix; without the Brij 35, peptide-(419-436) displayed no helical content. The Kd for the peptide-(419-436) blocking CD4 binding to gp120 in Brij 35-containing buffer was found to be 42 µ. These results indicate that C4 constructs from HIV-1 and HIV-2 do bind CD4, but the constructs must display an α-helical conformation to do so. In addition, the results reported here will provide answers to key questions about structural requirements for HIV vaccines and therapeutics that hinge on understanding the molecular nature of the gp120-CD4 interaction as the first step in the HIV infection process.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002231&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell leukemia virus type I tax protein transactivates RNA polymerase III promoter in vitro and in vivo.
AU  - Piras, G.
AU  - Dittmer, J.
AU  - Radonovich, M. F.
AU  - Brady, J. N.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 34
SP  - 20501
EP  - 20506
SN  - 0021-9258
AD  - Piras, G.: Laboratory of Molecular Virology, NCI, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001091.  Publication Type: Journal Article.  Language: English.  Number of References: 74 ref. Registry Number: 9014-24-8, 9026-28-2. 
KW  - HTLV infections
KW  - human diseases
KW  - rna polymerase
KW  - tax protein
KW  - transactivation
KW  - transcription
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - RNA nucleotidyltransferase
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001091&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Deficiency in β1,3-galactosyltransferase of a Leishmania major lipophosphoglycan mutant adversely influences the Leishmania-sand fly interaction.
AU  - Butcher, B. A.
AU  - Turco, S. J.
AU  - Hilty, B. A.
AU  - Pimenta, P. F.
AU  - Panunzio, M.
AU  - Sacks, D. L.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 34
SP  - 20573
EP  - 20579
SN  - 0021-9258
AD  - Butcher, B. A.: Laboratory of Parasitic Diseases, Intracellular Parasite Biology Section, National Institutes of Health, Bethesda, MD 28092, USA.
N1  - Accession Number: 19970801100.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 128449-51-4.  Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2  - To study the function of side chain oligosaccharides of the cell-surface lipophosphoglycan (LPG), mutant Leishmania major defective in side chain biosynthesis were negatively selected by agglutination with the monoclonal antibody WIC79.3, which recognizes the galactose-containing side chains of L. major LPG. One such mutant (Spock) lacked the ability to bind significantly to midguts of the natural L. major vector, Phlebotomus papatasi, and to maintain infection in the sand fly after excretion of the digested blood meal. Biochemical characterization of Spock LPG revealed its structural similarity to the LPG of L. donovani, a species whose inability to bind to and maintain infections in P. papatasi midguts has been strongly correlated with the expression of a surface LPG lacking galactose-terminated oligosaccharide side chains. An in vitro galactosyltransferase assay using wild-type or Spock membranes was used to determine that the defect in Spock LPG biosynthesis is a result of defective β1,3-galactosyltransferase activity as opposed to a modification of LPG, which would prevent it from serving as a competent substrate for galactose addition. The results showed that Spock lacks the β1,3-galactosyltransferase for side chain addition and that the LPG side chains are required for L. major to bind to and to produce transmissible infection in P. papatasi.
KW  - biochemistry
KW  - carbohydrates
KW  - disease transmission
KW  - disease vectors
KW  - host parasite relationships
KW  - lipophosphoglycans
KW  - midgut
KW  - mutants
KW  - N-acetyllactosaminide 3-alpha-galactosyltransferase
KW  - oligosaccharides
KW  - parasites
KW  - Diptera
KW  - Leishmania donovani
KW  - Leishmania major
KW  - Phlebotominae
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Psychodidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - galactosyltransferase
KW  - parasite host relationships
KW  - saccharides
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801100&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease.
AU  - Saxena, S. K.
AU  - Gravell, M.
AU  - Wu YouNeng
AU  - Mikulski, S. M.
AU  - Shogen, K.
AU  - Ardelt, W.
AU  - Youle, R. J.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 34
SP  - 20783
EP  - 20788
SN  - 0021-9258
AD  - Saxena, S. K.: Biochemistry Section of the Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972001090.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 63231-63-0. 
N2  - Ribonucleases appear to have physiological roles in host defence against cancer, viruses, and other parasites. Previously it was shown that select ribonucleases added to cells concurrently with virions blocked HIV-1 infection of H9 cells. The authors now report that a ribonuclease homologous to RNase A, named onconase, inhibits virus replication in chronically HIV-1-infected human cells without killing the virally infected cell. Examining the mechanism of this inhibition shows that onconase enters the infected cells and degrades HIV-1 RNA without degrading ribosomal RNA or the three different cellular messenger RNAs analysed. The homologous human pancreatic RNase lacks antiviral activity. Comparing recombinant forms of onconase and a onconase-human RNase chimera shows that the N-terminal 9 amino acids and the pyroglutamyl residue of onconase are required for full antiviral activity. Thus extracellular ribonucleases can enter cells, metabolize select RNAs, and inhibit HIV virion production within viable replicating cells.
KW  - antiviral properties
KW  - degradation
KW  - enzymes
KW  - hiv-1 infections
KW  - human diseases
KW  - inhibition
KW  - production
KW  - replication
KW  - ribonucleases
KW  - rna
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - human immunodeficiency virus type 1
KW  - onconase
KW  - ribonucleic acid
KW  - RNASE
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001090&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The catalytic domain of Acanthamoeba myosin I heavy chain kinase. I. Identification and characterization following tryptic cleavage of the native enzyme.
AU  - Brzeska, H.
AU  - Martin, B. M.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 43
SP  - 27049
EP  - 27055
SN  - 0021-9258
AD  - Brzeska, H.: Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970801970.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9026-43-1, 9002-07-7.  Subject Subsets: Protozoology
N2  - The actin-activated Mg2+-ATPase activities of the myosin I isoenzymes from Acanthamoeba castellanii are greatly increased by phosphorylation catalysed by myosin I heavy chain kinase (MIHC kinase), a monomeric 97-kDa protein whose activity is greatly enhanced by acidic phospholipids and by autophosphorylation of multiple sites. It was shown that the 35-kDa COOH-terminal fragment obtained by trypsin cleavage of maximally activated, autophosphorylated kinase retains the full activity and 2 to 3 of the autophosphorylation sites of the native enzyme. Other autophosphorylation sites occur in the middle third of the native enzyme. A trypsin cleavage site within the 35-kDa region is protected in phosphorylated kinase but is readily cleaved in unphosphorylated kinase producing catalytically inactive 25- and 11-kDa fragments from the NH2- and COOH-terminal ends, respectively, of the 35-kDa peptide. This implies that the conformation around the "25/11" cleavage site changes upon phosphorylation of the native enzyme. The position of this site corresponds to the activation loop of protein kinase A. Exogenously added MIHC kinase phosphorylates the 11-kDa fragment but not the 25-kDa fragment, indicating that the phosphorylation sites of the 35-kDa catalytic fragment are located within the COOH-terminal 11-kDa. The cloning, sequencing and expression of a fully active 35-kDa catalytic domain are described.
KW  - cleavage
KW  - enzymes
KW  - isoenzymes
KW  - kinases
KW  - molecular weight
KW  - myosins
KW  - parasites
KW  - peptides
KW  - phosphorylation
KW  - protein kinase
KW  - proteins
KW  - trypsin
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - isozymes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801970&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The catalytic domain of Acanthamoeba myosin I heavy chain kinase. II. Expression of active catalytic domain and sequence homology to p21-activated kinase (PAK).
AU  - Brzeska, H.
AU  - Szczepanowska, J.
AU  - Hoey, J.
AU  - Korn, E. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 43
SP  - 27056
EP  - 27062
SN  - 0021-9258
AD  - Brzeska, H.: Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970801915.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9026-43-1.  Subject Subsets: Protozoology
N2  - Acanthamoeba castellanii myosin I heavy chain (MIHC) kinase is a monomeric 97-kDa protein that is activated by binding to acidic phospholipids or by autophosphorylation. Activation by phospholipids is inhibited by Ca2+-calmodulin. The cloning, sequencing and expression of the cDNA corresponding to the COOH-terminal 35 kDa catalytic domain of MIHC kinase are described. The expressed catalytic domain showed substrate specificity similar to that of native kinase and resistance to trypsin similar to that of fully phosphorylated MIHC kinase. The MIHC kinase catalytic domain had only 25% sequence identity to the catalytic domain of protein kinase A and similarly low sequence identity to the catalytic domains of protein kinase C- and calmodulin-dependent kinases, but 50% sequence identity and 70% similarity to the p21-activated kinase (PAK) and STE20 family of kinases. This suggests that MIHC kinase is evolutionarily related to the PAK family, whose activities are regulated by small GTP-binding proteins. The homology includes the presence of a potential MIHC kinase autophosphorylation site as well as conserved Tyr and Ser/Thr residues in the region corresponding to the P+1 loop of protein kinase A. A synthetic peptide corresponding to this region of MIHC kinase is phosphorylated by both the expressed catalytic domain and native MIHC kinase. [Nucleotide sequence data submitted to GenBank, accession number U67056].
KW  - amino acid sequences
KW  - amino acids
KW  - complementary DNA
KW  - enzymes
KW  - evolution
KW  - gene expression
KW  - kinases
KW  - molecular genetics
KW  - myosins
KW  - parasites
KW  - protein kinase
KW  - proteins
KW  - synthetic peptides
KW  - Acanthamoeba castellanii
KW  - protozoa
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - cDNA
KW  - cloning
KW  - myosin
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801915&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site..
AU  - Mazumder, A.
AU  - Neamati, N.
AU  - Pilon, A. A.
AU  - Sunder, S.
AU  - Pommier, Y.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 44
SP  - 27330
EP  - 27338
SN  - 0021-9258
AD  - Mazumder, A.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001022.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9007-49-2. 
N2  - An assay for monitoring the DNA binding of HIV-1 integrase and the effect of cofactors and inhibitors, is described. The assay uses depurinated oligonucleotides that can form a Schiff base between the aldehydic abasic site and a nearby enzyme lysine ε-amino group which can subsequently be trapped by reduction with sodium borohydride. Chemically depurinated duplex substrates representing the U5 end of the HIV-1 DNA were initially used. An enzymatically generated abasic site was substituted for each of 10 nucleotides normally present in a 21-mer duplex oligonucleotide representing the U5 end of the HIV-1 DNA. Using HIV-1, HIV-2 or SIV integrases, the amount of covalent enzyme-DNA complex trapped decreased as the abasic site was moved away from the conserved CA dinucleotide. The enzyme-DNA complexes formed in the presence of manganese were not reversed by subsequent addition of EDTA, indicating that the divalent metal required for integrase catalysis is tightly bound in a ternary enzyme-metal-DNA complex. Both the N- and C-terminal domains of integrase contributed to efficient DNA binding and mutation of Lys-136 significantly reduced Schiff base formation, implicating this residue in viral DNA binding.
KW  - DNA
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - integration
KW  - microbiology
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1.
AU  - Chun, R. F.
AU  - Jeang KuanTeh
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 44
SP  - 27888
EP  - 27894
SN  - 0021-9258
AD  - Chun, R. F.: Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972001008.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Registry Number: 63231-63-0, 9014-24-8, 9026-28-2. 
N2  - An α-amanitin-resistant system was used to study the role of the carboxyl-terminal domain (CTD) in the regulated transcription of HTLV-I and HIV-1, developed previously. Transcription directed by the HTLV-I activator protein Tax was strongly promoted by CTD-deficient RNA polymerase II. In contrast, the HIV-1 activator Tat, which is recruited to the promoter by tethering to a nascent leader RNA, required CTD-containing polymerase II for transcriptional activity. Biochemically, Tat associated with a cellular CTD kinase activity, whereas Tax did not. Concordantly, cellular transcription factor Sp1, which can activate CTD-deficient polymerase II with an efficiency similar to Tax, also failed to bind a CTD kinase.
KW  - hiv infections
KW  - human diseases
KW  - microbiology
KW  - promoters
KW  - RNA
KW  - rna polymerase
KW  - transcription
KW  - transcription factors
KW  - Deltaretrovirus
KW  - Human immunodeficiency virus 1
KW  - human t-cell lymphotropic virus type i
KW  - retroviridae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - DNA transcription
KW  - genomic structure
KW  - HTLV-BLV group
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - promoter region
KW  - promoter sequences
KW  - ribonucleic acid
KW  - RNA nucleotidyltransferase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cysteine protease activated by expression of HIV-1 protease in transgenic mice. MIP26 (aquaporin-0) cleavage and cataract formation in vivo and ex vivo.
AU  - Mitton, K. P.
AU  - Kamiya, T.
AU  - Tumminia, S. J.
AU  - Russell, P.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1996///
VL  - 271
IS  - 50
SP  - 31803
EP  - 31806
SN  - 0021-9258
AD  - Mitton, K. P.: Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001390.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 52-90-4. 
N2  - Transgenic mice, homozygous for HIV-1 protease expression in the eye lens, display degradation of some lens crystallins and cytoskeletal proteins prior to cataract formation on postnatal days 23-25. Alterations to the internal lens hydration state also occur; therefore, the status of the aquaporin protein MIP26 was examined over postnatal days 16-25 to determine if it was altered during cataractogenesis. The MIP was identical in transgenic and control lenses until day 21. By postnatal day 25 (frank cataract), in the lenses obtained from transgenic animals, the 26-kDa band was absent and there was a concurrent increase in the proportion of MIP23. Immunoblotting demonstrated cleavage at the C terminus. Lenses were also maintained in an organ culture system to demonstrate that the cataractogenic process is inherent to the isolated lens and to determine the contribution of cysteine protease action. Organ culture experiments revealed a similar progression to nuclear cataract formation as seen in vivo. Two-dimensional gel analysis of the soluble lens crystallin fraction of organ cultured lenses revealed the same cleavage pattern as occurs in vivo. Organ culture of transgenic lenses with E64, a cysteine protease inhibitor, dramatically delayed cataractogenesis and prevented proteolytic cleavage of both MIP26 and crystallins. HIV-1 protease, while the trigger of cataract formation, does not appear to be the protease responsible for cleavage of MIP or lens crystallins. These results suggest that activation is involved in the cleavage of these proteins and occurs downstream of HIV-1 protease action.
KW  - antigens
KW  - cataract
KW  - cysteine
KW  - cysteine proteinases
KW  - eye diseases
KW  - eyes
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - microbiology
KW  - proteinases
KW  - proteins
KW  - proteolysis
KW  - structural genes
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001390&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
AU  - Yu Feng
AU  - Broder, C. C.
AU  - Kennedy, P. E.
AU  - Berger, E. A.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1996///
VL  - 272
IS  - 5263
SP  - 872
EP  - 877
SN  - 0036-8075
AD  - Yu Feng: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962009192.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
N2  - A cofactor for HIV-1 fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated "fusin", is a putative G protein-coupled receptor with 7 transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1-Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD+ human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T-cell-line-tropic isolates, in comparison to its activity with macrophage-tropic HIV-1 isolates [See also J. Cohen, pp. 809-810, for comment on the significance of this work.]
KW  - cd4 antigens
KW  - CD4+ lymphocytes
KW  - cell fusion
KW  - cofactors
KW  - HIV-1 infections
KW  - human diseases
KW  - macrophages
KW  - pathogenesis
KW  - receptors
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - CD4+ cells
KW  - fusin
KW  - human immunodeficiency virus type 1
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009192&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1.
AU  - Alkhatib, G.
AU  - Combadiere, C.
AU  - Broder, C. C.
AU  - Yu Feng
AU  - Kennedy, P. E.
AU  - Murphy, P. M.
AU  - Berger, E. A.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1996///
VL  - 272
IS  - 5270
SP  - 1955
EP  - 1958
SN  - 0036-8075
AD  - Alkhatib, G.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
N1  - Accession Number: 19962008604.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref.
N2  - HIV-1 entry requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T-cell line-tropic isolates. The chemokines RANTES, MIP-1α, and MIP-1β, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains.
KW  - cell fusion
KW  - chemokines
KW  - cofactors
KW  - cytokines
KW  - HIV-1 infections
KW  - human diseases
KW  - macrophages
KW  - pathogenesis
KW  - phenotypes
KW  - receptors
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008604&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas.
AU  - Hinnebusch, B. J.
AU  - Perry, R. D.
AU  - Schwan, T. G.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1996///
VL  - 273
IS  - 5273
SP  - 367
EP  - 370
SN  - 0036-8075
AD  - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19970500220.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - Biological transmission of plague depends on blockage of the foregut of the vector flea by a mass of plague bacilli. Blockage in Xenopsylla cheopis was found to be dependent on the haemin storage (hms) locus. Y. pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops. Thus, the hms locus markedly alters the course of Y. pestis infection in its insect vector, leading to a change in blood-feeding behaviour and to efficient transmission of plague.
KW  - disease transmission
KW  - disease vectors
KW  - feeding
KW  - foregut
KW  - genes
KW  - infection
KW  - infections
KW  - laboratory animals
KW  - midgut
KW  - mutants
KW  - transmission
KW  - mice
KW  - Siphonaptera
KW  - Xenopsylla cheopis
KW  - Yersinia pestis
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - Xenopsylla
KW  - Pulicidae
KW  - Siphonaptera
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - haemin
KW  - hemin
KW  - Oriental rat flea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500220&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene.
AU  - Dean, M.
AU  - Carrington, M.
AU  - Winkler, C.
AU  - Huttley, G. A.
AU  - Smith, M. W.
AU  - Allikmets, R.
AU  - Goedert, J. J.
AU  - Buchbinder, S. P.
AU  - Vittinghoff, E.
AU  - Gomperts, E.
AU  - Donfield, S.
AU  - Vlahov, D.
AU  - Kaslow, R.
AU  - Saah, A.
AU  - Rinaldo, C.
AU  - Detels, R.
AU  - O'Brien, S. J.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1996///
VL  - 273
IS  - 5283
SP  - 1856
EP  - 1862
SN  - 0036-8075
AD  - Dean, M.: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19962009453.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref.
KW  - alleles
KW  - disease course
KW  - genes
KW  - genetics
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mutations
KW  - structural genes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009453&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ocular manifestations of AIDS.
AU  - Whitcup, S. M.
AU  - Young, L. H. Y.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 275
IS  - 2
SP  - 142
EP  - 144
SN  - 0098-7484
AD  - Whitcup, S. M.: National Eye Institute, 10 Center Dr. Building 10, Room 10N202, Bethesda, MD 20892-1858, USA.
N1  - Accession Number: 19962001814.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref.
KW  - acquired immune deficiency syndrome
KW  - clinical aspects
KW  - eye diseases
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - opportunistic infections
KW  - retinitis
KW  - treatment
KW  - cytomegalovirus
KW  - man
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001814&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluating new vaccines for developing countries: efficacy or effectiveness?
AU  - Clemens, J.
AU  - Brenner, R.
AU  - Rao, M.
AU  - Tafari, N.
AU  - Lowe, C.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 275
IS  - 5
SP  - 390
EP  - 397
SN  - 0098-7484
AD  - Clemens, J.: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
N1  - Accession Number: 19962004457.  Publication Type: Journal Article.  Language: English.  Number of References: 87 ref. Subject Subsets: Public Health
N2  - In this article, the authors review the conventional sequence of clinical evaluations of new vaccines under consideration for developing countries and explain how the typical perspective of contemporary vaccine trials may obscure rather than enlighten rational decision making about the introduction of new vaccines in these settings. They also describe how these problems may be remedied by supplementing conventional trials with new types of trials designed to evaluate the practical costs and benefits of new vaccines.
KW  - human diseases
KW  - immunization
KW  - infectious diseases
KW  - reviews
KW  - Developing countries
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - countries
KW  - communicable diseases
KW  - immune sensitization
KW  - Third World
KW  - Underdeveloped Countries
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004457&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary protein and blood pressure.
AU  - Obarzanek, E.
AU  - Velletri, P. A.
AU  - Cutler, J. A.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 275
IS  - 20
SP  - 1598
EP  - 1603
SN  - 0098-7484
AD  - Obarzanek, E.: National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, 2 Rockledge Centre, MSC 7936, 6701 Rockledge Dr. Room 8136, Bethesda, MD 20892-7936, USA.
N1  - Accession Number: 19961407468.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Human Nutrition
N2  - The relationship between dietary protein and blood pressure in man and animals is reviewed.
KW  - animal models
KW  - blood pressure
KW  - protein intake
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407468&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum HIV-1 RNA levels and time to development of AIDS in the multicenter hemophilia cohort study.
AU  - O'Brien, T. R.
AU  - Blattner, W. A.
AU  - Waters, D.
AU  - Eyster, M. E.
AU  - Hilgartner, M. W.
AU  - Cohen, A. R.
AU  - Luban, N.
AU  - Hatzakis, A.
AU  - Aledort, L. M.
AU  - Rosenberg, P. S.
AU  - Miley, W. J.
AU  - Kroner, B. L.
AU  - Goedert, J. J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 276
IS  - 2
SP  - 105
EP  - 110
SN  - 0098-7484
AD  - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Rockville, MD 20852, USA.
N1  - Accession Number: 19962007626.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 63231-63-0. 
KW  - disease course
KW  - haemophilia
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - prognosis
KW  - risk groups
KW  - RNA
KW  - seroconversion
KW  - serology
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - disease progression
KW  - hemophilia
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007626&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevalence of dementia in older Japanese-American men in Hawaii. The Honolulu-Asia aging study.
AU  - White, L.
AU  - Petrovitch, H.
AU  - Ross, W.
AU  - Masaki, K. H.
AU  - Abbott, R. D.
AU  - Teng, E. L.
AU  - Rodriguez, B. L.
AU  - Blanchette, P. L.
AU  - Havlik, R. J.
AU  - Wergowske, G.
AU  - Chiu, D.
AU  - Foley, D. J.
AU  - Murdaugh, C.
AU  - Curb, J. D.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 276
IS  - 12
SP  - 955
EP  - 960
SN  - 0098-7484
AD  - White, L.: National Institute of Aging, Honolulu Heart Program, Honolulu-Asia Aging Study, 347 N Kuakini St, Honolulu, HI 96817, USA.
N1  - Accession Number: 19962008508.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Public Health; Tropical Diseases
N2  - The Honolulu Heart Program is a prospective population-based study of cardiovascular disease established in 1965. Prevalence estimates were computed from cases identified at the 1991 to 1993 examination. Cognitive performance was assessed using standardized methods, instruments, and diagnostic criteria. Subjects were 3734 Japanese-American men (80% of surviving cohort) aged 71 through 93 years, living in the community or in institutions. Age-specific, age-standardized, and cohort prevalence estimates were computed for dementia (all cause) defined by 2 sets of diagnostic criteria and 4 levels of severity. Prevalence levels for Alzheimer's disease and vascular dementia were also estimated. Dementia prevalence ranged from 2.1% in men aged 71 through 74 years to 33.4% in men aged 85 through 93 years. Age-standardized prevalence was 7.6%. Prevalence estimates for the cohort were 9.3% for dementia (all cause), 5.4% for Alzheimer's disease (primary or contributing), and 4.2% for vascular dementia (primary or contributing). More than one possible cause was found in 26% of cases. The Alzheimer's disease/vascular dementia ratio was 1.5 for cases attributed primarily to Alzheimer's disease or vascular dementia. It is concluded that prevalence of Alzheimer's disease in older Japanese-American men in Hawaii appears to be higher than in Japan but similar to European-ancestry populations. Prevalence of vascular dementia appears to be only slightly lower than in Japan, but higher than in European-ancestry populations. Further cross-national research with emphasis on standardized diagnostic methods is needed.
KW  - alzheimer's disease
KW  - dementia
KW  - disease prevalence
KW  - elderly
KW  - human diseases
KW  - men
KW  - Hawaii
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Polynesia
KW  - Oceania
KW  - Pacific Islands
KW  - aged
KW  - elderly people
KW  - older adults
KW  - senior citizens
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008508&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines.
AU  - Robbins, J. B.
AU  - Schneerson, R.
AU  - Anderson, P.
AU  - Smith, D. H.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 276
IS  - 14
SP  - 1181
EP  - 1185
SN  - 0098-7484
AD  - Robbins, J. B.: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19962009168.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Subject Subsets: Public Health
KW  - bacterial diseases
KW  - conjugate vaccines
KW  - disease prevention
KW  - human diseases
KW  - immunization
KW  - infections
KW  - meningitis
KW  - reviews
KW  - vaccination
KW  - vaccines
KW  - Haemophilus influenzae type b
KW  - man
KW  - Haemophilus influenzae
KW  - Haemophilus
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009168&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships.
AU  - Quinn, T. C.
AU  - Gaydos, C.
AU  - Shepherd, M.
AU  - Bobo, L.
AU  - Hook, E. W., III
AU  - Viscidi, R.
AU  - Rompalo, A.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1996///
VL  - 276
IS  - 21
SP  - 1737
EP  - 1742
SN  - 0098-7484
AD  - Quinn, T. C.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19972001684.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Public Health
N2  - The aim of this study in Maryland, USA, was to determine the frequency of Chlamydia trachomatis genital infection within sexual partnerships and to identify the variables that might modify transmission. 494 people in sexual partnerships attending sexually transmitted disease clinics in Baltimore were included. DNA sequencing was performed to examine specific genotypes within and between partnerships. Cross-sectional analysis was performed to determine characteristics associated with concordance or discordance of infection with partnerships. Cultures were positive for C. trachomatis in 8.5% of males and 12.9% of females (P = 0.03). Using PCR, more infections were identified both in males (14.2%) and in females (15.8%), and the difference in infection rates analysed by sex was no longer significant. In 20.4% of 494 couples, at least 1 partner had PCR results positive for C. trachomatis, with a concordant infection rate of 10.7%, significantly higher than the 5.5% concordant infection rate demonstrable by culture (P &lt;0.01). Male-female and female-male transmission frequencies were equal (68%). The nucleotide sequences of the major outer membrane protein gene products were identical and unique for each of 15 culture-negative, PCR-positive concordant partnerships. In concordant infections, factors associated with infection in female partners were age &lt;20 years, &gt;1 partner in the past 6 months, and cervical ectopy &gt;25%. Using PCR, the frequency of chlamydia transmission by infected males and females was nearly identical. The high rate of concordant infection, high frequency of infection among asymptomatic individuals, and high frequency of transmission regardless of sex underscore the importance of routine screening for chlamydia in both males and females, along with provision of treatment to all sexual partners of chlamydia-infected individuals.
KW  - bacterial diseases
KW  - disease prevalence
KW  - disease transmission
KW  - epidemiology
KW  - female genital diseases
KW  - genotypes
KW  - human diseases
KW  - infections
KW  - male genital diseases
KW  - sexual partners
KW  - Maryland
KW  - North America
KW  - USA
KW  - Chlamydia trachomatis
KW  - man
KW  - Chlamydia
KW  - Chlamydiaceae
KW  - Chlamydiales
KW  - Chlamydiae
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001684&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1.
AU  - Currens, M. J.
AU  - Gulakowski, R. J.
AU  - Mariner, J. M.
AU  - Moran, R. A.
AU  - Buckheit, R. W., Jr.
AU  - Gustafson, K. R.
AU  - McMahon, J. B.
AU  - Boyd, M. R.
JO  - Journal of Pharmacology and Experimental Therapeutics
JF  - Journal of Pharmacology and Experimental Therapeutics
Y1  - 1996///
VL  - 279
IS  - 2
SP  - 645
EP  - 651
SN  - 0022-3565
AD  - Currens, M. J.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick Cancer Research & Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001198.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref.
KW  - antiviral agents
KW  - antiviral properties
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - anti-viral properties
KW  - calanolides
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - non-nucleoside RT inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001198&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A.
AU  - Currens, M. J.
AU  - Mariner, J. M.
AU  - McMahon, J. B.
AU  - Boyd, M. R.
JO  - Journal of Pharmacology and Experimental Therapeutics
JF  - Journal of Pharmacology and Experimental Therapeutics
Y1  - 1996///
VL  - 279
IS  - 2
SP  - 652
EP  - 661
SN  - 0022-3565
AD  - Currens, M. J.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001199.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
KW  - antiviral agents
KW  - antiviral properties
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - anti-viral properties
KW  - calanolides
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - non-nucleoside RT inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001199&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Avian exposure and risk of lung cancer in women in Missouri: population based case-control study.
AU  - Alavanja, M. C. R.
AU  - Brownson, R. C.
AU  - Berger, E.
AU  - Lubin, J.
AU  - Modigh, C.
JO  - British Medical Journal (Clinical Research edition)
JF  - British Medical Journal (Clinical Research edition)
Y1  - 1996///
VL  - 313
IS  - 7067
SP  - 1233
EP  - 1235
SN  - 0959-8138
AD  - Alavanja, M. C. R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19972009228.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Public Health
N2  - To investigate the association between ownership of pet birds and the risk of lung cancer, a population based case-control study was conducted in the USA with a structured questionnaire administered by telephone. All newly diagnosed female primary lung cancer cases aged 30-84 years in Missouri, reported to the state cancer registry during 1 January 1993-31 January 1994, were invited to participate (n=652) together with 629 population-based controls. Odds ratios were computed in relation to whether or not the study subject ever kept pet birds, the type of bird kept, and several measures of intensity or duration of exposure. Odds ratios were adjusted for smoking. The odds ratio (95% confidence interval) for the development of lung cancer associated with keeping pet birds was 0.84 (0.65 to 1.09). The results were similar for the type of pet bird kept, the number of birds kept, the location of the bird in the house, and the duration of ownership. It is concluded that the keeping of pet birds carries no excess risk for the development of lung cancer.
KW  - aetiology
KW  - aviary birds
KW  - human diseases
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - pets
KW  - risk factors
KW  - women
KW  - Missouri
KW  - North America
KW  - USA
KW  - birds
KW  - man
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cage birds
KW  - cancer sites
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - pet animals
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin.
AU  - Omatsu-Kanbe, M.
AU  - Zarnowski, M. J.
AU  - Cushman, S. W.
JO  - Biochemical Journal (London)
JF  - Biochemical Journal (London)
Y1  - 1996///
VL  - 315
IS  - 1
SP  - 25
EP  - 31
SN  - 0264-6021
AD  - Omatsu-Kanbe, M.: Experimental Diabetes, Metabolism and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19961407443.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 58-61-7, 50-99-7, 9004-10-8, 299-95-6, 51-30-9, 6700-39-6, 76853-59-2.  Subject Subsets: Human Nutrition
N2  - Isolated brown adipose cells from male Sprague-Dawley rats were prepared whose viability was indicated by the expected stimulation of oxygen consumption by noradrenaline and counter-regulation of this oxygen consumption response by insulin. Insulin stimulates 3-O-methyl-D-glucose transport by about 15-fold in the absence of adenosine, and adenosine augments this response at least 2-fold. The insulin-stimulated translocation of the glucose transporter GLUT4 from an intracellular compartment to the plasma membrane is readily detected by subcellular fractionation and Western blotting, and the appearance of GLUT4 on the cell surface in response to insulin is demonstrated by bis-mannose photolabelling. Isoprenaline also stimulates glucose transport activity but only by about 3-fold; this effect is not altered by adenosine. Isoprenaline increases insulin-stimulated glucose transport activity in the absence of adenosine but decreases it in the presence of adenosine. These results demonstrate that although the regulation of glucose transport by insulin in brown adipose cells is qualitatively similar to that in white adipose cells, counter-regulation by adenosine and isoprenaline is at least quantitatively and may be qualitatively different. Isolated brown adipose cells from rats thus represent an excellent model for further examination of the mechanism by which multiple hormone signalling pathways interact to control glucose transport and GLUT4 subcellular trafficking.
KW  - adenosine
KW  - brown fat
KW  - glucose
KW  - insulin
KW  - isoprenaline
KW  - transport
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - dextrose
KW  - isoproterenol
KW  - transportation
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407443&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene expression of iron-related proteins during iron deficiency caused by scurvy in guinea pigs.
AU  - Gosiewska, A.
AU  - Mahmoodian, F.
AU  - Peterkofsky, B.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1996///
VL  - 325
IS  - 2
SP  - 295
EP  - 303
SN  - 0003-9861
AD  - Gosiewska, A.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892-4255, USA.
N1  - Accession Number: 19971401658.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 50-81-7, 9007-73-2, 7439-89-6, 11096-37-0.  Subject Subsets: Human Nutrition
N2  - The study aimed to find out at what stage of scurvy iron deficiency occurred and whether changes in expression of iron-related proteins during scurvy resulted directly from iron depletion or from systemic changes associated with weight loss. Guinea pigs were fed on an ascorbic acid-free diet and controls were given a 25 mg/100 g body weight ascorbic acid supplement. Serum iron decreased to 75-54% of normal during the first phase of ascorbic acid deficiency (ascorbic acid depletion, no weight loss, 0-21 days) and then decreased further in the second phase when weight loss began to occur (21-30 days). Unsaturated iron binding capacity increased to almost 4 times normal by 30 days of ascorbic acid-free diet. Ferritin L subunit concentrations decreased while H subunit was still detectable and transferrin concentrations increased on ascorbic acid-free diet. Hepatic cytosolic aconitase activity decreased to about 43% of normal in the first phase of scurvy and decreased further when weight-loss occurred, to about 28% of normal. Hepatic RNA concentrations were measured for transferrin (Tf), ferritin L subunit (FL), ferritin H subunit (FH), iron regulatory protein 1 (IRP-1) and transferrin receptor protein (TfR). TfR concentrations increased after only 7 days of ascorbic acid deficiency and continued to increase to about 5 times normal. IRP-1, FL and Tf RNAs decreased significantly even before weight loss occurred. FH RNA was not decreased significantly until the guinea pigs had lost 24-28% body weight. In conclusion vitamin C depletion leads to iron deficiency in guinea pigs which begins before weight loss occurs and leads to iron related gene expression changes which do not involve insulin-like growth factor-binding protein.
KW  - ascorbic acid
KW  - blood
KW  - deficiency
KW  - ferritin
KW  - gene expression
KW  - iron
KW  - metabolism
KW  - receptors
KW  - regulation
KW  - scurvy
KW  - trace elements
KW  - transferrin
KW  - vitamin deficiencies
KW  - vitamins
KW  - guineapigs
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - guinea pigs
KW  - microelements
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401658&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bacterial pneumonia in HIV.
AU  - Cohen, J. I.
AU  - Hirschtick, R. E.\Glassroth, J.\Jordan, M. C.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1996///
VL  - 334
IS  - 3
SP  - 195
EP  - 195
SN  - 0028-4793
AD  - Cohen, J. I.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962002048.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref.
KW  - acquired immune deficiency syndrome
KW  - bacterial diseases
KW  - clinical aspects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunization
KW  - pneumonia
KW  - vaccines
KW  - man
KW  - Streptococcus pneumoniae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Streptococcus
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - AIDS
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - clinical picture
KW  - Haemophilus influenza
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002048&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1.
AU  - Stanley, S. K.
AU  - Ostrowski, M. A.
AU  - Justement, J. S.
AU  - Gantt, K.
AU  - Hedayati, S.
AU  - Mannix, M.
AU  - Roche, K.
AU  - Schwartzentruber, D. J.
AU  - Fox, C. H.
AU  - Fauci, A. S.
AU  - Greene, W. C.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1996///
VL  - 334
IS  - 19
SP  - 1222
EP  - 1230
SN  - 0028-4793
AD  - Stanley, S. K.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg. 30, Rm. 7A03, 31 Center Dr., MSC-2520, Bethesda, MD 20892-2520, USA.
N1  - Accession Number: 19962009187.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
N2  - [See also W. C. Greene, pp. 1264-65.]
KW  - antigens
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - immunopathology
KW  - pathogenesis
KW  - tetanus toxoid
KW  - viraemia
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - immunopathogenesis
KW  - recall antigens
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009187&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The cloning and clinical implications of HGV and HGBV-C.
AU  - Alter, H. J.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1996///
VL  - 334
IS  - 23
SP  - 1536
EP  - 1537
SN  - 0028-4793
AD  - Alter, H. J.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962005881.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Public Health
N2  - This editorial discusses the nomenclature of viral hepatitis agents and the identification, epidemiology and pathology of the newly identified hepatitis G virus and hepatitis GB virus C.
KW  - aetiology
KW  - clinical aspects
KW  - editorials
KW  - epidemiology
KW  - human diseases
KW  - identification
KW  - viral diseases
KW  - hepatitis G virus
KW  - man
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - causal agents
KW  - clinical picture
KW  - cloning
KW  - etiology
KW  - hepatitis GB virus C
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005881&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hepatitis C virus-associated fulminant hepatic failure.
AU  - Farci, P.
AU  - Alter, H. J.
AU  - Shimoda, A.
AU  - Govindarajan, S.
AU  - Cheung, L. C.
AU  - Melpolder, J. C.
AU  - Sacher, R. A.
AU  - Shih, J. W.
AU  - Purcell, R. H.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1996///
VL  - 335
IS  - 9
SP  - 631
EP  - 634
SN  - 0028-4793
AD  - Farci, P.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19962008057.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Public Health
N2  - In this report, a patient in the USA with HCV-associated fulminant hepatitis is described in whom serial studies were done that provided a unique opportunity to establish a temporal association between the acquisition of HCV infection and the development of fulminant hepatitis and to define the clinical, virological, and histological profile of fulminant hepatitis C.
KW  - case reports
KW  - clinical aspects
KW  - diagnosis
KW  - hepatitis C
KW  - human diseases
KW  - liver failure
KW  - District of Columbia
KW  - North America
KW  - USA
KW  - hepatitis C virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - clinical picture
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008057&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Zidovudine alone or in combination with didanosine or zalcitabine in HIV-infected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter.
AU  - Saravolatz, L. D.
AU  - Winslow, D. L.
AU  - Collins, G.
AU  - Hodges, J. S.
AU  - Pettinelli, C.
AU  - Stein, D. S.
AU  - Markowitz, N.
AU  - Reves, R.
AU  - Loveless, M. O.
AU  - Crane, L.
AU  - Thompson, M.
AU  - Abrams, D.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1996///
VL  - 335
IS  - 15
SP  - 1099
EP  - 1106
SN  - 0028-4793
AD  - Saravolatz, L. D.: Correspondence address: Dr L. Deyton, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962009080.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 69655-05-6, 7841-89-2, 30516-87-1. 
KW  - adverse effects
KW  - clinical trials
KW  - combination therapy
KW  - didanosine
KW  - dideoxycytidine
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - zidovudine
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - AZT
KW  - chemotherapy
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - multimodal treatment
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009080&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus.
AU  - Kovacs, J. A.
AU  - Vogel, S.
AU  - Albert, J. M.
AU  - Falloon, J.
AU  - Davey, R. T., Jr.
AU  - Walker, R. E.
AU  - Polis, M. A.
AU  - Spooner, K.
AU  - Metcalf, J. A.
AU  - Baseler, M.
AU  - Fyfe, G.
AU  - Lane, H. C.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1996///
VL  - 335
IS  - 18
SP  - 1350
EP  - 1356
SN  - 0028-4793
AD  - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19972000217.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
N2  - A controlled study to evaluate the long-term effects of intermitten transfusions of interleukin-2 on both CD4+ counts and viral burden in 60 HIV-infected patients from the USA, is reported. In patients treated with interleukin-2, the mean CD4+
KW  - adverse effects
KW  - antiviral agents
KW  - clinical trials
KW  - cytokines
KW  - drug therapy
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunomodulators
KW  - immunotherapy
KW  - interleukins
KW  - t lymphocytes
KW  - treatment
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000217&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation and properties of bone alkaline phosphatase during vitamin C deficiency in Guinea pigs.
AU  - Mahmoodian, F.
AU  - Gosiewska, A.
AU  - Peterkofsky, B.
JO  - Archives of Biochemistry and Biophysics
JF  - Archives of Biochemistry and Biophysics
Y1  - 1996///
VL  - 336
IS  - 1
SP  - 86
EP  - 96
SN  - 0003-9861
AD  - Mahmoodian, F.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892-4255, USA.
N1  - Accession Number: 19981403748.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 9001-78-9, 50-81-7, 104982-03-8.  Subject Subsets: Human Nutrition
KW  - alkaline phosphatase
KW  - ascorbic acid
KW  - bones
KW  - collagen
KW  - deficiency
KW  - gene expression
KW  - osteocalcin
KW  - regulation
KW  - scurvy
KW  - vitamins
KW  - guineapigs
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - alkaline phosphomonoesterase
KW  - guinea pigs
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403748&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Autoimmunity and onchocerciasis.
AU  - Cooper, P. J.
T2  - Lancet (British edition)
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1996///
VL  - 347
IS  - 8998
SP  - 404
EP  - 404
SN  - 0140-6736
AD  - Cooper, P. J.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19960803993.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - So-called autoimmunity in Onchocerca volvulus infections is considered to be related to a widespread non-specific activation of the immune system due to massive antigen load, rather than to an immunopathogenic mechanism.
KW  - antigens
KW  - autoimmune diseases
KW  - autoimmunity
KW  - helminths
KW  - human diseases
KW  - immunological diseases
KW  - immunology
KW  - immunopathology
KW  - onchocerciasis
KW  - parasites
KW  - man
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - immunogens
KW  - immunopathogenesis
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803993&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Perinatal intervention trial in Africa: effect of a birth canal cleansing intervention to prevent HIV transmission.
AU  - Biggar, R. J.
AU  - Miotti, P. G.
AU  - Taha, T. E.
AU  - Mtimavalye, L.
AU  - Broadhead, R.
AU  - Justesen, A.
AU  - Yellin, F.
AU  - Liomba, G.
AU  - Miley, W.
AU  - Waters, D.
AU  - Chiphangwi, J. D.
AU  - Goedert, J. J.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1996///
VL  - 347
IS  - 9016
SP  - 1647
EP  - 1650
SN  - 0140-6736
AD  - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19962007232.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
KW  - disease prevention
KW  - disease transmission
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - maternal transmission
KW  - pregnancy
KW  - women
KW  - Malawi
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - mother to child transmission
KW  - Nyasaland
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007232&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Global burden of the HIV pandemic.
AU  - Quinn, T. C.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1996///
VL  - 348
IS  - 9020
SP  - 99
EP  - 106
SN  - 0140-6736
AD  - Quinn, T. C.: National Institute of Allergy and Infectious Diseases, Johns Hopkins University, Baltimore, MD 21205-2196, USA.
N1  - Accession Number: 19962007087.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref.
KW  - disease transmission
KW  - epidemics
KW  - epidemiology
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007087&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Changing the natural history of HIV disease.
AU  - Feinberg, M. B.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1996///
VL  - 348
IS  - 9022
SP  - 239
EP  - 246
SN  - 0140-6736
AD  - Feinberg, M. B.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19962007653.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref.
KW  - clinical aspects
KW  - disease course
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - pathogenesis
KW  - serology
KW  - survival
KW  - t lymphocytes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - clinical picture
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007653&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A toxoid vaccine for pertussis as well as diphtheria? Lessons to be relearned.
AU  - Schneerson, R.
AU  - Robbins, J. B.
AU  - Taranger, J.
AU  - Lagergård, T.
AU  - Trollfors, B.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1996///
VL  - 348
IS  - 9037
SP  - 1289
EP  - 1292
SN  - 0140-6736
AD  - Schneerson, R.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, NIH, Room 424, Building 6, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972003629.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Public Health
N2  - Vaccines for pertussis and diphtheria are reviewed with emphasis on the development and efficacy of toxoid vaccines.
KW  - acellular vaccines
KW  - bacterial diseases
KW  - bacterial toxins
KW  - diphtheria
KW  - efficacy
KW  - human diseases
KW  - immunity
KW  - immunization
KW  - inactivated vaccines
KW  - pertussis
KW  - reviews
KW  - vaccination
KW  - vaccine development
KW  - vaccines
KW  - bordetella pertussis
KW  - corynebacterium diphtheriae
KW  - man
KW  - Bordetella
KW  - Alcaligenaceae
KW  - Burkholderiales
KW  - Betaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Corynebacterium
KW  - Corynebacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - immune sensitization
KW  - killed vaccines
KW  - whooping cough
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003629&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis.
AU  - Wachsman, J. T.
JO  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1  - 1996///
VL  - 350
IS  - 1
SP  - 25
EP  - 34
SN  - 0027-5107
AD  - Wachsman, J. T.: Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19961410515.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 75 ref. Registry Number: 9007-49-2.  Subject Subsets: Human Nutrition
N2  - This article is an expanded version of a talk given at the 4th International Conference on Antimutagenesis and Anticarcinogenesis, September 4-9, 1994, Banff, Alberta, Canada. Studies that have examined the effects of dietary restriction on oxidative damage and apoptosis are reviewed and the beneficial effect of these on aging and carcinogenesis are also discussed.
KW  - aging
KW  - animal models
KW  - apoptosis
KW  - carcinogenesis
KW  - damage
KW  - DNA
KW  - food restriction
KW  - free radicals
KW  - lipid peroxidation
KW  - mitochondria
KW  - mutagenesis
KW  - oxidation
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - deoxyribonucleic acid
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410515&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protective selective pressure.
AU  - Miller, L. H.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1996///
VL  - 383
IS  - 6600
SP  - 480
EP  - 481
SN  - 0028-0836
AD  - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970800547.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - The finding of T.N. Williams et al. [Nature (1996) 383 (6600), 522-525] that on the island of Espiritu Santo in Vanuatu, there was an increased incidence of malaria in children who were homozygous for α+-thalassaemia is discussed. This is interpreted by the authors as being evidence for a protective effect of α+-thalassaemia against dying from malaria. They suggest that protection may result from an increased incidence of mild malaria in early childhood, which generates increased immunity and reduces the likelihood of a subsequent life-threatening severe attack.
KW  - alpha-thalassaemia
KW  - children
KW  - epidemiology
KW  - human diseases
KW  - malaria
KW  - parasites
KW  - resistance
KW  - selection pressure
KW  - thalassaemia
KW  - Australasia
KW  - Vanuatu
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Oceania
KW  - ACP Countries
KW  - Commonwealth of Nations
KW  - Least Developed Countries
KW  - Developing Countries
KW  - Melanesia
KW  - Australasia
KW  - Pacific Islands
KW  - alpha-thalassemia
KW  - New Hebrides
KW  - thalassemia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800547&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Host factors and the pathogenesis of HIV-induced disease.
AU  - Fauci, A. S.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1996///
VL  - 384
IS  - 6609
SP  - 529
EP  - 534
SN  - 0028-0836
AD  - Fauci, A. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001213.  Publication Type: Journal Article.  Language: English.  Number of References: 113 ref.
N2  - The role of host factors in the pathogenesis of HIV-induced disease is reviewed, particularly cellular activation and the role of cytokines and their receptors in regulating viral replication and in pathogenesis. Exogenous factors and HIV replication, endogenous cytokines, suppression of HIV replication, viral co-receptors and cellular tropisms, co-receptors and resistance to infection, progression of HIV-induced disease and therapeutic and preventive strategies are discussed.
KW  - cytokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - immunopathology
KW  - pathogenesis
KW  - reviews
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001213&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gliosis in the LP-BM5 murine leukemia virus infected mouse: an animal model of retrovirus-induced dementia.
AU  - Kustova, Y.
AU  - Sei, Y.
AU  - Goping, G.
AU  - Basile, A. S.
JO  - Brain Research
JF  - Brain Research
Y1  - 1996///
VL  - 742
IS  - 1/2
SP  - 271
EP  - 282
SN  - 0006-8993
AD  - Kustova, Y.: Laboratory of Neuroscience, Bldg 8, Rm 111, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972002941.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
N2  - Mice infected with the LP-BM5 murine leukaemia virus (MuLV) mixture develop severe immunosuppression, neurotransmitter abnormalities and cognitive impairments in the absence of significant viral or macrophage invasion of the CNS. The time-course of the changes in glial activation have been characterized in an effort to understand the cellular basis of the neurobehavioural abnormalities observed in these mice. Glial activation was determined by measuring the relative changes in F4/80 protein and GFAP immunoreactivity using immunoblots. Augmented F4/80 expression preceded that of GFAP, with global elevations of 4-6 fold at 3 weeks, sustained for up to 12 weeks after inoculation. GFAP immunoreactivity increased 2-fold only in the cerebral cortex and striatum 5 weeks postinfection, declining to control levels by 12 weeks. Immunohistochemistry revealed significant increases in microglial size and staining intensity in the cortex, corpus callosum and striatum, with the development of a unique population of highly ramified, intensely stained microglia and microglial nodules in the corpus callosum and striatum.
KW  - abnormalities
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - brain
KW  - dementia
KW  - HIV-1 infections
KW  - human diseases
KW  - immunohistochemistry
KW  - leukaemia
KW  - macrophages
KW  - neuroglia
KW  - nodules
KW  - pathology
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Murine leukemia virus
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Gammaretrovirus
KW  - AIDS
KW  - blood cancer
KW  - cerebrum
KW  - glial cells
KW  - human immunodeficiency virus type 1
KW  - leucaemia
KW  - leukemia
KW  - murine leukaemia virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002941&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Production of a malaria transmission-blocking protein from recombinant yeast.
AU  - Wang, M. Y.
AU  - Kaslow, D. C.
AU  - Shiloach, J.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1996///
VL  - 782
SP  - 123
EP  - 132
SN  - 0077-8923
AD  - Wang, M. Y.: Biotechnology Unit NIDDK Molecular Vaccine Section NISID National Institutes of Health Bethesda, MD 20892, USA.
N1  - Accession Number: 19980801996.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref.
KW  - human diseases
KW  - malaria
KW  - recombinant proteins
KW  - transmission blocking immunity
KW  - vaccine development
KW  - yeasts
KW  - man
KW  - Plasmodium
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801996&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human papillomavirus immunology and vaccine prospects.
AU  - Steller, M. A.
AU  - Schiller, J. T.
JO  - Journal of the National Cancer Institute Monographs
JF  - Journal of the National Cancer Institute Monographs
Y1  - 1996///
IS  - 21
SP  - 145
EP  - 148
AD  - Steller, M. A.: National Institutes of Health, Bethesda, MD 20892-1502, USA.
N1  - Accession Number: 19982000023.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref.
N2  - Therapeutic and prophylactic vaccines in the prevention of human papillomavirus (HPV) infections and HPV-related cervical cancer are discussed.
KW  - cervical cancer
KW  - human diseases
KW  - immunization
KW  - infections
KW  - neoplasms
KW  - vaccines
KW  - viral diseases
KW  - women
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Papillomaviridae
KW  - cancers
KW  - human papillomavirus
KW  - immune sensitization
KW  - Papovaviridae
KW  - viral infections
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Biology and tropism of human immunodeficiency virus-1 in the nervous system.
AU  - Conant, K. E.
AU  - Monaco, M. G.
AU  - Major, E. O.
A2  - Berger, J. R.
A2  - Levy, R. M.
T2  - AIDS and the nervous system.
JO  - AIDS and the nervous system.
JF  - AIDS and the nervous system.
Y1  - 1996///
IS  - Ed. 2
SP  - 39
EP  - 57
CY  - Philadelphia; USA
PB  - Lippincott-Raven Publishers
SN  - 0781703093
AD  - Conant, K. E.: Laboratory of Molecular Medicine and Neuroscience, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972007313.  Publication Type: Miscellaneous.  Language: English.  Number of References: 171 refs.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nervous system diseases
KW  - pathogenesis
KW  - tropisms
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - neuropathy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007313&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Food allergy in adults.
AU  - Metcalfe, D. D.
A2  - Metcalfe, D. D.
A2  - Sampson, H. A.
A2  - Simon, R. A.
T2  - Food allergy: adverse reactions to food and food additives.
Y1  - 1996///
IS  - Ed. 2
CY  - Cambridge; USA
PB  - Blackwell Science Inc.
SN  - 0865424322
AD  - Metcalfe, D. D.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19971407184.  Publication Type: Book chapter.  Language: English.  Number of References: 67 ref. Registry Number: 308067-57-4.  Subject Subsets: Human Nutrition; Soyabeans
N2  - The prevalence of food hypersensitivity reactions in adults and the pathogenesis of immunoglobulin E (IgE)-mediated hypersensitivity reactions are reviewed. Common allergenic foods including groundnuts, soyabeans, shrimps, fish and eggs are identified. Clinical patterns of target organ responses, in vivo and in vitro and oral challenge diagnostic tests and the management of food allergy are discussed. The characteristics and treatment of allergic eosinophilic gastroenteritis, gluten-sensitive enteropathy (coeliac disease) and dermatitis herpetiformis are described.
KW  - adults
KW  - allergens
KW  - coeliac syndrome
KW  - diagnosis
KW  - eggs
KW  - fish
KW  - food allergies
KW  - gastrointestinal diseases
KW  - groundnuts
KW  - hypersensitivity
KW  - immunoglobulins
KW  - shrimps
KW  - soyabeans
KW  - Arachis hypogaea
KW  - Glycine (Fabaceae)
KW  - man
KW  - Decapoda
KW  - Malacostraca
KW  - Crustacea
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - aquatic animals
KW  - aquatic organisms
KW  - eukaryotes
KW  - Arachis
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - allergic responses
KW  - celiac disease
KW  - celiac syndrome
KW  - coeliac disease
KW  - food hypersensitivity
KW  - gamma-globulins
KW  - gluten allergy
KW  - hypersensitiveness
KW  - immune globulins
KW  - peanuts
KW  - soybeans
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Crop Produce (QQ050) 
KW  - Aquatic Produce (QQ060) 
KW  - Eggs and Egg Products (QQ040) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Food allergy: adverse reactions to food and food additives.
A2  - Metcalfe, D. D.
A2  - Sampson, H. A.
A2  - Simon, R. A.
T2  - Food allergy: adverse reactions to food and food additives.
Y1  - 1996///
IS  - Ed. 2
CY  - Cambridge; USA
PB  - Blackwell Science Inc.
SN  - 0865424322
AD  - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19971407100.  Publication Type: Book.  Language: English.  Number of References: many ref. Registry Number: 308067-57-4, 142-47-2.  Subject Subsets: Human Nutrition
N2  - This book on food allergy is divided into 4 parts: the basic science of adverse reactions to food antigens; the clinical science of adverse reactions to food antigens; adverse reactions to food additives; and contemporary topics in adverse reactions to foods. Individual chapters address: mucosal immunity; mast cells, basophils and immunoglobulin E; food antigens; food biotechnology and genetic engineering; antigen absorption; oral tolerance: immune responses to food antigens; in vitro diagnostic methods in the evaluation of food hypersensitivity; skin testing and oral challenge procedures; immediate reactions to foods in infants and children; food allergy in adults; eczema and food hypersensitivity; food-induced urticaria; oral allergy syndrome; the respiratory tract and food hypersensitivity; anaphylaxis and food allergy; infantile colic and food hypersensitivity; eosinophilic gastroenteritis; food protein-induced colitis and gastroenteropathy in children; gluten-sensitive enteropathy (coeliac disease); exercise- and pressure-induced syndromes; occupational reactions to food allergens; adverse reactions to sulfites; monosodium glutamate; tartrate, azo and nonazo dyes; adverse reactions to benzoates and parabens; adverse reactions to the antioxidants butylated hydroxyanisole and butylated hydroxytoluene; urticaria, angioedemia, and anaphylaxis provoked by food additives; asthma and food additives; phamacological food reactions; management of food allergy; natural history and prevention of food hypersensitivity; diets and nutrition; food toxicology; neurological reactions to foods and food additives; behaviour and adverse food reactions; psychological considerations of food allergy; connective tissue reactions to foods; and unproved diagnostic and therapeutic techniques. Summaries of individual chapters are presented elsewhere in this issue of NAR/A.
KW  - adults
KW  - anaphylaxis
KW  - antigens
KW  - asthma
KW  - biotechnology
KW  - blood cells
KW  - children
KW  - coeliac syndrome
KW  - colic
KW  - diagnosis
KW  - diet
KW  - eczema
KW  - food additives
KW  - food allergies
KW  - food colourants
KW  - gastrointestinal diseases
KW  - genetic engineering
KW  - hypersensitivity
KW  - immune response
KW  - immunoglobulins
KW  - infants
KW  - monosodium glutamate
KW  - mucosa
KW  - occupations
KW  - psychology
KW  - sulfites
KW  - toxic substances
KW  - urticaria
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - allergic responses
KW  - anaphylactic reactions
KW  - anaphylactic shock
KW  - antigenicity
KW  - celiac disease
KW  - celiac syndrome
KW  - coeliac disease
KW  - food colorants
KW  - food hypersensitivity
KW  - gamma-globulins
KW  - genetic manipulation
KW  - gluten allergy
KW  - hypersensitiveness
KW  - immune globulins
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - mucous membrane
KW  - nettle rash
KW  - poisons
KW  - psychological factors
KW  - sulphites
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407100&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Insect-transmitted pathogens in the insect midgut.
AU  - Kaslow, D. C.
AU  - Welburn, S.
A2  - Lehane, M. J.
A2  - Billingsley, P. F.
T2  - Biology of the insect midgut.
JO  - Biology of the insect midgut.
JF  - Biology of the insect midgut.
Y1  - 1996///
SP  - 432
EP  - 462
CY  - London; UK
PB  - Chapman & Hall Ltd
SN  - 041261670X
AD  - Kaslow, D. C.: Malaria Vaccines Section, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980501272.  Publication Type: Miscellaneous.  Language: English.  Number of References: 8 pp. of ref. Subject Subsets: Medical & Veterinary Entomology
N2  - This review focuses on the transitions that occur when a pathogen establishes itself in an invertebrate vector. Some vector genetic and/or susceptibility factors that contribute to the establishment of midgut infections are also reviewed. Protozoans, filariae, arboviruses and bacteria are considered in different sections.
KW  - arboviruses
KW  - development
KW  - disease vectors
KW  - haematophagous insects
KW  - host parasite relationships
KW  - infections
KW  - midgut
KW  - pathogens
KW  - reviews
KW  - bacteria
KW  - Leishmania
KW  - Nematoda
KW  - Plasmodium
KW  - Protozoa
KW  - Trypanosoma
KW  - prokaryotes
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - arthropod-borne viruses
KW  - bacterium
KW  - bloodsucking insects
KW  - filariae
KW  - hematophagous insects
KW  - nematodes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501272&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Transmission-blocking vaccines.
AU  - Kaslow, D. C.
A2  - Hoffman, S. L.
T2  - Malaria vaccine development: a multi-immune response approach.
Y1  - 1996///
CY  - Washington; USA
PB  - American Society for Microbiology (ASM)
SN  - 1555811116
AD  - Kaslow, D. C.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970801980.  Publication Type: Book chapter.  Language: English.  Number of References: 106 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - This chapter covers: biology of the sexual stages of the malaria parasite; development of transmission-blocking vaccines; immune responses to sexual-stage antigens in humans (antigenic diversity, boosting after natural infection, immunogenicity to prefertilization target antigens); progress towards developing vaccines against specific antigens (mechanisms of antibody-dependent protective immune responses, current status of efforts to design, produce and evaluate vaccines to induce antibodies to target antigens in experimental model systems, current status of efforts to design, produce and evaluate vaccines to induce antibodies to target antigens in humans, current status of field trials of transmission-blocking vaccines).
KW  - human diseases
KW  - malaria
KW  - parasites
KW  - reviews
KW  - transmission blocking immunity
KW  - vaccine development
KW  - vaccines
KW  - Plasmodium
KW  - protozoa
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - transmission blocking vaccines
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801980&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Racial/ethnic patterns of cancer in the United States, 1988-1992.
AU  - Miller, B. A.
AU  - Kolonel, L. N.
AU  - Bernstein, L.
AU  - Young, J. L., Jr.
AU  - Swanson, G. M.
AU  - West, D.
AU  - Key, C. R.
AU  - Liff, J. M.
AU  - Glover, C. S.
AU  - Alexander, G. A.
A2  - Miller, B. A.
A2  - Kolonel, L. N.
A2  - Bernstein, L.
A2  - Young, J. L., Jr.
A2  - Swanson, G. M.
A2  - West, D.
A2  - Key, C. R.
A2  - Liff, J. M.
A2  - Glover, C. S.
A2  - Alexander, G. A.
T2  - Racial/ethnic patterns of cancer in the United States, 1988-1992
T3  - NIH Pub. No. 96-4104
Y1  - 1996///
CY  - Bethesda; USA
PB  - National Cancer Institute (NCI)
AD  - Miller, B. A.: Surveillance Research Program, Division of Cancer and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 20083240998.  Publication Type: Book.  Note: NIH Pub. No. 96-4104 Language: English.  Subject Subsets: Public Health
N2  - This monograph provides a description of the occurrence of the major cancers among several different racial/ethnic groups in the USA. Age-adjusted incidence rates are shown graphically by age group and sex for Alaska Native, American Indian (New Mexico), black, Chinese, Filipino, Hawaiian, Hispanic, Japanese, Korean, Vietnamese, white (total), white Hispanic and white non-Hispanic populations. Age-adjusted mortality rates are also shown for these groups, with the exception of Koreans and Vietnamese, for whom national data are not yet available. Incidence rates are provided by the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute and are based on newly diagnosed cancers between 1988 and 1992 for a subset of the United States population. Mortality rates are provided by the National Center for Health Statistics and are based on cancer deaths between 1988 and 1992 for the entire United States population. The cancers included in this report are organized alphabetically. They are followed by a section on cancer control efforts in special population groups and an appendix. The appendix contains tables showing the number of newly diagnosed cancers, by racial/ethnic group, in specific regions of the USA during 1988-1992. It also includes estimates for the entire country of the number of newly diagnosed cancers and the number of cancer deaths in 1990. The intent of this publication is to promote a greater understanding of the cancer problem in the United States, to identify those who can benefit most by education on the potential risks and consequences of certain behaviours and exposures, and to indicate areas where more knowledge and scientific investigation are needed to understand why cancer occurs more frequently in some groups of people than others.
KW  - African Americans
KW  - Asians
KW  - blacks
KW  - disease incidence
KW  - epidemiology
KW  - ethnic groups
KW  - ethnicity
KW  - Hispanics
KW  - human diseases
KW  - immigrants
KW  - neoplasms
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - ethnic differences
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Demography (UU200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083240998&site=ehost-live&scope=site
UR  - http://seer.cancer.gov/publications/ethnicity/
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Initiation and regulation of CD4+ T-cell function in host-parasite models.
AU  - Jankovic, D.
AU  - Sher, A.
A2  - Romagnani, S.
T2  - Th1 and Th2 cells in health and disease.
Y1  - 1996///
CY  - Basel; Switzerland
PB  - S Karger AG
SN  - 3805562411
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19960804253.  Publication Type: Book chapter.  Language: English.  Number of References: 67 ref. Subject Subsets: Helminthology; Protozoology
N2  - This review concentrates on 2 parasites which represent different extremes (Toxoplasma gondii which induces strong type 1 cytokine responses, and Schistosoma mansoni which is associated predominantly with a type 2 cytokine production pattern). Aspects discussed include: cellular basis of polarized cytokine expression in parasitic infections; maintenance of polarized responses in established infection; mechanisms underlying the initiation of polarized responses in different parasitic infections.
KW  - CD4+ lymphocytes
KW  - cytokines
KW  - helminths
KW  - immune response
KW  - parasites
KW  - reviews
KW  - protozoa
KW  - Schistosoma mansoni
KW  - Toxoplasma gondii
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - CD4+ cells
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - t helper cells
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804253&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Anopheline mosquitoes and the agents they transmit.
AU  - Gwadz, R.
AU  - Collins, F. H.
A2  - Beaty, B. J.
A2  - Marquardt, W. C.
T2  - The biology of disease vectors.
Y1  - 1996///
CY  - Niwot, CO; USA
PB  - University Press of Colorado
SN  - 0870814117
AD  - Gwadz, R.: Laboratory of Malaria Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970501078.  Publication Type: Book chapter.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
KW  - control
KW  - disease transmission
KW  - disease vectors
KW  - host parasite relationships
KW  - life cycle
KW  - mosquito-borne diseases
KW  - parasites
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501078&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Yeast infections in the immunocompromised host.
AU  - Walsh, T. J.
A2  - Howard, D. H.
A2  - Miller, J. D.
T2  - The Mycota. A comprehensive treatise on fungi as experimental systems for basic and applied research. Volume VI: Human and animal relationships.
Y1  - 1996///
CY  - Berlin; Germany
PB  - Springer-Verlag
SN  - 3540580077
AD  - Walsh, T. J.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19961200681.  Publication Type: Book chapter.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The epidemiology, clinical manifestations, diagnosis and treatment of infections in immunocompromised hosts caused by Candida and Cryptococcus neoformans are discussed. Infections due to other yeasts such as Trichosporon beigelii, Blastoschizomyces capitatus, Malassezia furfur and dematiaceous yeasts such as Wangiella dermatitidis are also briefly considered.
KW  - candidosis
KW  - clinical aspects
KW  - cryptococcosis
KW  - diagnosis
KW  - drug therapy
KW  - epidemiology
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunosuppression
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - phaeohyphomycosis
KW  - predisposition
KW  - therapy
KW  - yeasts
KW  - Candida
KW  - Cryptococcus neoformans
KW  - Exophiala dermatitidis
KW  - Malassezia furfur
KW  - man
KW  - Trichosporon beigelii
KW  - Trichosporon capitatum
KW  - fungi
KW  - eukaryotes
KW  - Blastoschizomyces
KW  - Dipodascaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Malassezia
KW  - Malasseziales
KW  - Ustilaginomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Herpotrichiellaceae
KW  - Chaetothyriales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Exophiala
KW  - Blastoschizomyces capitatus
KW  - candidiasis
KW  - chemotherapy
KW  - chromomycosis
KW  - clinical picture
KW  - european blastomycosis
KW  - fungus
KW  - Hyphomycetes
KW  - therapeutics
KW  - Wangiella
KW  - Wangiella dermatitidis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Parental expressed needs: a preliminary guide for services and interventions.
AU  - Wiener, L.
AU  - Riekert, K.
AU  - Steinberg, S. M.
AU  - Pizzo, P.
JO  - Journal of HIV/AIDS Prevention and Education for Adolescents and Children
JF  - Journal of HIV/AIDS Prevention and Education for Adolescents and Children
Y1  - 1997///
VL  - 1
IS  - 1
SP  - 35
EP  - 52
AD  - Wiener, L.: Pediatric HIV Psychosocial Support Program, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972000327.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref.
N2  - This study examined the expressed needs of 150 caregivers of HIV-infected children. The authors assessed the frequency of reported needs and examined the effect of variables that may influence them. The variables include: the caregiver's relationship to the child, his/her HIV-status, and race, the age of the child, the route of transmission, and the child's awareness of his or her own HIV diagnosis. The study delineates the different needs articulated by caregivers for the HIV-infected children at three different developmental stages, and by the caregivers' HIV-status and relationship to the children. The most urgent needs found were for mental health services and health education. The age of the child, the parent's HIV status, and the child's awareness of his or her diagnosis had the most impact on the types of services caregivers requested.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - community care
KW  - diagnosis
KW  - effects
KW  - families
KW  - health services
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - psychosocial aspects
KW  - relationships
KW  - sociology
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - social aspects
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Health Services (UU350) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000327&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin.
AU  - Biro, T.
AU  - Acs, G.
AU  - Acs, P.
AU  - Modarres, S.
AU  - Blumberg, P. M.
JO  - Journal of Investigative Dermatology, Symposium Proceedings
JF  - Journal of Investigative Dermatology, Symposium Proceedings
Y1  - 1997///
VL  - 2
IS  - 1
SP  - 56
EP  - 60
AD  - Biro, T.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19970310475.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 56 ref. Registry Number: 7440-70-2, 404-86-4, 33507-63-0.  Subject Subsets: Horticultural Science
N2  - C-fiber sensory afferent neurons, which contain neuropeptides such as calcitonin-gene related peptide and substance P, mediate a wide variety of physiologic responses, including chemogenic pain, thermoregulation, and neurogenic inflammation. Capsaicin, the pungent constituent in red pepper [Capsicum spp.], functions to activate and then, at higher doses and longer times, desensitize this class of neurons. This latter response provides the basis for the therapeutic application of capsaicin. A major advance in the field has been the identification of resiniferatoxin, a phorbol-related diterpene from the latex of Euphorbia resinifera, as an analogue of capsaicin that is ultrapotent but with differential selectivity. In particular, resiniferatoxin is only similar in potency for induction of pain but is much more effective for desensitization. Structure-activity analysis in whole animal experiments provides further evidence for dissociation of biologic endpoints, strongly arguing for the existence of vanilloid receptor subclasses. Using resiniferatoxin, it has been possible to define specific, high-affinity receptors for capsaicin both in animal models such as rats, and in man. Of great importance, the pharmacologic characterization in cultured dorsal root ganglion cells of the high-affinity resiniferatoxin-binding site and of the physiologic response believed to be directly coupled to the receptor, viz. calcium uptake, differed in structure-activity and in cooperativity. It is concluded that multiple high-affinity vanilloid receptor subclasses mediate vanilloid response; moreover, the resiniferatoxin-selective subclass of vanilloid receptors is not the voltage-independent, cation-nonselective ion channel as previously believed. Optimization of ligands for the individual vanilloid receptor subclasses should revolutionize this therapeutic area.
KW  - analogues
KW  - binding
KW  - calcium
KW  - capsaicin
KW  - inflammation
KW  - medicinal plants
KW  - medicinal properties
KW  - neurons
KW  - neuropeptides
KW  - pain
KW  - pharmacology
KW  - receptors
KW  - skin
KW  - structure activity relationships
KW  - substance P
KW  - uptake
KW  - Capsicum
KW  - Euphorbia
KW  - Solanaceae
KW  - Solanales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Euphorbiaceae
KW  - Euphorbiales
KW  - Euphorbia
KW  - analogs
KW  - dermis
KW  - drug plants
KW  - Euphorbia resinifera
KW  - medicinal herbs
KW  - nerve cells
KW  - neurones
KW  - officinal plants
KW  - resiniferatoxin
KW  - vanilloid receptors
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Non-food/Non-feed Plant Products (SS200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk.
AU  - Zimmerman, P. A.
AU  - Buckler-White, A.
AU  - Alkhatib, G.
AU  - Spalding, T.
AU  - Kubofcik, J.
AU  - Combadiere, C.
AU  - Weissman, D.
AU  - Cohen, O.
AU  - Rubbert, A.
AU  - Lam, G.
AU  - Vaccarezza, M.
AU  - Kennedy, P. E.
AU  - Kumaraswami, V.
AU  - Giorgi, J. V.
AU  - Detels, R.
AU  - Hunter, J.
AU  - Chopek, M.
AU  - Berger, E. A.
AU  - Fauci, A. S.
AU  - Nutman, T. B.
AU  - Murphy, P. M.
JO  - Molecular Medicine
JF  - Molecular Medicine
Y1  - 1997///
VL  - 3
IS  - 1
SP  - 23
EP  - 36
AD  - Zimmerman, P. A.: Correspondence address [Nutman, T. B.]: Laboratory of Parasitic Diseases, Building 5, Rm 126, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19972004106.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 9007-49-2. 
N2  - CCR5-2 was independently identified and its effects tested on HIV-1 pathogenesis in individuals with contrasting clinical outcomes, defined race, and quantified risk. Mutant CCR5 alleles were sought by directed heteroduplex analysis of genome DNA from random blood donors. Genotypic frequencies were then determined in (1) random blood donors from North America, Asia, and Africa; (2) HIV-1+ individuals; and (3) highly exposed-seronegative homosexuals with quantified risk. CCR5-2 was the only mutant allele found. It was common in Caucasians, less common in other North American racial groups, and not detected in West Africans or Tamil Indians. Homozygous CCR5-2 frequencies differed reciprocally in highly exposed-seronegative (4.5%, n=111) and HIV-1 seropositive (0%, n=614) Caucasians relative to Caucasian random blood donors (0.8%, n=387). This difference was highly significant (P&lt;0.0001). By contrast, heterozygous CCR5-2 frequencies did not differ significantly in the same three groups (21.6, 22.6, and 21.7%, respectively). A 55% increase in the frequency of heterozygous CCR5-2 was observed in both of 2 cohorts of Caucasian homosexual male, long-term nonprogressors compared with other HIV-1+ Caucasian homosexuals (P=0.006) and compared with Caucasian random blood donors. Moreover, Kaplan-Meier estimates indicated that CCR5-2 heterozygous seroconverters had a 52.6% lower risk of developing AIDS than homozygous wild-type seroconverters. The data suggest that homozygous CCR5-2 is an HIV-1 resistance factor in Caucasians with complete penetrance and that heterozygous CCR5-2 slows the rate of disease progression in infected Caucasian homosexuals. Since the majority (~96%) of highly exposed-seronegative individuals tested are not homozygous for CCR5-2, other resistance factors must exist. Since CCR5-2 homozygotes have no obvious clinical problems, CCR5 may be a good target for the development of novel antiretroviral therapy.The nucleic acid sequence of CCR5-2 has been deposited in Genbank, #U66285.Editorial Comment:The impact of CCR5 on HIV infection risk and disease progression.At least 4 chemokine receptors, CXCR4, CCR2B, CCR3 and CCR5 are cofactors, along with CD4 and the viral envelope protein, gp120 in the first step of HIV's entry into cells. Macrophage-tropic strains of HIV use CCR3 and CCR5 whereas T-cell tropic (syncytium producing) strains use CXCR4 and CCR5 preferentially. CCR5 encodes a receptor for the CC chemokines MIP-1a, MIP-1b and RANTES, and is probably, the site through which these chemokines inhibit the growth of macrophage-tropic strains of HIV. CCR5 exists in two alleles: CCR5-1, the wild type and CCR5-2, which has a 32 base-pair deletion. The mutant allele found is racially restricted, found much more frequently in whites than in Afro-Americans, Hispanics or Native-Americans. Homozygosity for the mutant allele is associated with apparently complete resistance to infection with HIV and heterozygosity is associated with a decreased risk of disease progression. This study quantitates these risks. In a cohort of HIV seroconverters followed for more than 10 years, heterozygotes had a 52.6% lower rate of progression to AIDS compared with individuals homozygous for CCR5-1. In addition, in studies of highly exposed but sero-negative individuals, only 4% were heterozygous for CCR5-2, suggesting that other factors for resistance to HIV infection exist, and should be sought.
KW  - alleles
KW  - chemokines
KW  - clinical aspects
KW  - disease course
KW  - dna
KW  - ethnic groups
KW  - genomes
KW  - human immunodeficiency viruses
KW  - pathogenesis
KW  - resistance
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cc chemokine receptor 5
KW  - clinical picture
KW  - deoxyribonucleic acid
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - non-progressors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004106&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.
AU  - Rice, W. G.
AU  - Turpin, J. A.
AU  - Huang MingJun
AU  - Clanton, D.
AU  - Buckheit, R. W., Jr.
AU  - Covell, D. G.
AU  - Wallqvist, A.
AU  - McDonnell, N. B.
AU  - DeGuzman, R. N.
AU  - Summers, M. F.
AU  - Zalkow, L.
AU  - Bader, J. P.
AU  - Haugwitz, R. D.
AU  - Sausville, E. A.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1997///
VL  - 3
IS  - 3
SP  - 341
EP  - 345
AD  - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, MD 21702, USA.
N1  - Accession Number: 19972003001.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 7440-66-6. 
N2  - Nucleocapsid p7 (NCp7) proteins of HIV-1 contain 2 zinc binding domains of the sequence Cys-(X)2-Cys-(X)4-His-(X)4-Cys (CHHC). The spacing pattern and metal-chelating residues (3 Cys, 1 His) of these nucleocapsid CCHC zinc fingers are highly conserved among retroviruses. These CCHC domains are required during both the early and late phases of retroviral replication, making them attractive targets for antiviral agents. Toward that end, a number of antiviral chemotypes were identified that electrophilically attack the sulfur atoms of the zinc-coordinating cysteine residues of the domains. Such nucleocapsid inhibitors were directly virucidal by preventing the initiation of reverse transcription and blocked formation of infectious virus from cells through modification of CCHC domains within Gag precursors. Herein, it is reported that azidocarbonamide (ADA) represents a new compound that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Vendevelde et al. (AIDS Research and Human Retrovirology, 1996, 12, p567) also recently disclosed that ADA inhibits HIV-1 infection via an unidentified mechanism and that ADA was introduced into Phase I/II clinical trials in Europe for advanced AIDS. These studies distinguish ADA as the first known nucleocapsid inhibitor to progress to human trials and provide a lead compound for drug optimization.
KW  - antiviral agents
KW  - binding
KW  - inhibitors
KW  - nucleocapsid proteins
KW  - proteins
KW  - replication
KW  - transcription
KW  - treatment
KW  - zinc
KW  - Human immunodeficiency virus 1
KW  - Retroviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - azidocarbonamide
KW  - DNA transcription
KW  - human immunodeficiency virus type 1
KW  - nucleocapsid inhibitors
KW  - other anti-HIV antivirals
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin.
AU  - Husain, S. R.
AU  - Gill, P.
AU  - Kreitman, R. J.
AU  - Pastan, I.
AU  - Puri, R. K.
JO  - Molecular Medicine
JF  - Molecular Medicine
Y1  - 1997///
VL  - 3
IS  - 5
SP  - 327
EP  - 338
AD  - Husain, S. R.: Correspondence address [Puri, R. K.]: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health-Bldg 29B, Rm 2NN10, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972006974.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 207137-56-2. 
N2  - The expression of interleukin-4 receptors (IL-4R) on AIDS-Kaposi's sarcoma (KS) cells and their subunit structure was determined by radioligand receptor binding cross-linking and Northern and RT-PCR analyses. The in vitro effect of IL-4 and recombinant fusion protein made up of circularly permuted IL-4 and a mutated form of Pseudomonas exotoxin IL-4(38-37)-PE38KDEL was examined by clonogenic and protein synthesis inhibition assays. Five AIDS-KS cell lines expressed high-affinity IL-4R with a Kd of 23.5-219 pM. IL-4 appeared to crosslink to one major protein corresponding to 140 kDa and a broad band corresponding to 60-70 kDa. Both cross-linked proteins were immunoprecipitated with an antibody to human IL-4Rβ chain. AIDS-KS cells exhibited IL-4Rβ-specific mRNA. IL-4 caused a modest inhibition (31-34%) of colony formation in two AIDS-KS cell lines tested. IL-4(38-37)-PE38KDEL was found to be highly effective in inhibiting the protein synthesis in all five AIDS-KS examined. The IC50 ranged from 32 to 1225 pM. The cytotoxic action of IL-4 toxin was blocked by an excess of IL-4 exhibiting the specificity of IL-4(38-37)-PE38KDEL. The cytotoxicity of IL-4 toxin observed by a clonogenic assay corroborated well with the IC50 obtained by protein synthesis inhibition assay. Normal human endothelial cells expressed a negligible number of IL-4R (&lt;50 sites/cell) and were less sensitive or not sensitive to IL-4(38-37)-PE38KDEL.
KW  - antibodies
KW  - antineoplastic agents
KW  - binding
KW  - cell lines
KW  - cytotoxicity
KW  - drug therapy
KW  - effects
KW  - endothelium
KW  - exotoxins
KW  - fusion proteins
KW  - in vitro
KW  - inhibition
KW  - interleukin 4
KW  - Kaposi's sarcoma
KW  - neoplasms
KW  - protein synthesis
KW  - proteins
KW  - receptors
KW  - sarcoma
KW  - structure
KW  - synthesis
KW  - toxins
KW  - treatment
KW  - man
KW  - Pseudomonas
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pseudomonadaceae
KW  - Pseudomonadales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - cancers
KW  - chemotherapy
KW  - cytotoxic agents
KW  - endothelial cells
KW  - protein biosynthesis
KW  - specificity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies.
AU  - Connors, M.
AU  - Kovacs, J. A.
AU  - Krevat, S.
AU  - Gea-Banacloche, J. C.
AU  - Sneller, M. C.
AU  - Flanigan, M.
AU  - Metcalf, J. A.
AU  - Walker, R. E.
AU  - Falloon, J.
AU  - Baseler, M.
AU  - Stevens, R.
AU  - Feuerstein, I.
AU  - Masur, H.
AU  - Lane, H. C.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1997///
VL  - 3
IS  - 5
SP  - 533
EP  - 540
AD  - Connors, M.: Correspondence address [Lane, H. C.]: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, Rm 11B-13, 10 Center Drive, Bethesda, MD 20892-1876, USA.
N1  - Accession Number: 19972005099.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4+ T cells increased only if they were present before initiation of therapy. Disruptions of the CD4+ TCR repertoire were most prevalent in patients with the lowest CD4+ T-cell counts. Antiviral or IL-12 therapy-induced increases in CD4+ T-cell counts led to only minor changes in previously disrupted repertoires. Thus, CD4+ T-cell death mediated by HIV-1 infection may result in a preferential decline in the number of naive CD4+ T cells and disruptions of the CD4+ T-cell repertoire that are not immediately corrected by antiviral or immune-based therapies.Editorial Comment:This is an extremely interesting and timely study which demonstrates that the CD4+ T-lymphocytic repertoire is not fully restored by potent antiretrovirals, with or without an immune-based therapy, in this case interleukin-12 (IL-12). Although there has been a renaissance in the treatment of HIV-1 disease, with potent combination chemotherapy, this has not always been fully helpful in immune reconstituting individuals with dramatically depleted CD4+ T-lymphocytes, prior to therapy. As such, it is also questionable whether the CD4+ T-cell diverse repertoire is at all corrected with these approaches. This is an interesting clinical and basic science study which demonstrates that there remains T-cell repertoire disruptions in patients with initial significant depletions in CD4+ lymphocytes, prior to antiviral therapy. As well, at least this one type of immune-based therapy was not fully helpful. Further studies and approaches are critically needed at this point in the AIDS epidemic in attempts to immune reconstitute patients, once viral replication has been functionally ablated by combination antiviral therapeutics. This paper confirms previous reports that, as the CD4+ count falls in progressive HIV infection, the naive CD4+ population is more severely affected than is the memory population (perhaps due to more resilient replicative potential of memory cells). Concordantly, memory cells recovered more rapidly after antiviral and IL2 therapy; and disturbingly, if the naive population was undetectable before therapy it did not reappear as the total CD4+ count rose. For TCR repertoire analysis a sophisticated technique was utilized. PCR amplification of the variable VDJ regions of TCR-β gene yields PCR fragments of on average 8 different lengths due to differences in amount of nucleotide additions. PCR was performed for each of the 22 TCR-β gene families and amount of PCR fragment of each length quantitated, allowing the repertoire analysis to be divided into 176 discrete measurements. Monozygotic twins discordant for HIV infection were studied, demonstrating obvious distortions of the TCR repertoire in HIV infection and indicating a much more severe limitation of repertoire than indicated by total CD4+ counts. Even as CD4+ counts rose towards normal levels after therapy, a normal TCR repertoire was not usually restored.
KW  - acquired immune deficiency syndrome
KW  - amplification
KW  - antigens
KW  - antiviral agents
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - clinical aspects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - infection
KW  - leukocyte count
KW  - patients
KW  - phenotypes
KW  - polymerase chain reaction
KW  - replication
KW  - T lymphocytes
KW  - treatment
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - AIDS
KW  - antigenicity
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - PCR
KW  - T cells
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005099&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite.
AU  - Rogers, M. J.
AU  - Bukhman, Y. V.
AU  - McCutchan, T. F.
AU  - Draper, D. E.
JO  - RNA
JF  - RNA
Y1  - 1997///
VL  - 3
IS  - 8
SP  - 815
EP  - 820
AD  - Rogers, M. J.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980802641.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 63231-63-0.  Subject Subsets: Protozoology
N2  - Temperature-dependent hyperchromicity profiles of synthetic RNAs corresponding to domains in the plastid and cytoplasmic RNAs of Plasmodium falciparum were examined. Thiostrepton induced a tertiary structure in the plastid-like fragment similar to that seen in eubacterial rRNA, even though they share only about 60% sequence identity. A single point mutation in the plastid-like fragment removed thiostrepton-dependent tertiary structure formation. Thus, the plastid and eubacterial RNAs share a stabilized tertiary structure induced by the drug. This direct indicator of drug sensitivity in eubacteria suggests that the plastid-encoded ribosome is similarly sensitive to thiostrepton and that the plastid is the site of drug action. Correlation of thiostrepton-sensitive and -resistant phenotypes with physical parameters suggests thiostrepton resistance as a selectable marker for plastid transformation.
KW  - antibiotics
KW  - antiprotozoal agents
KW  - mode of action
KW  - molecular genetics
KW  - mutations
KW  - parasites
KW  - ribosomes
KW  - RNA
KW  - transcription
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA transcription
KW  - ribonucleic acid
KW  - thiostrepton
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802641&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - CCR2 chemokine receptor and AIDS progression.
AU  - Smith, M. W.
AU  - Carrington, M.
AU  - Winner, C.
AU  - Lomb, D.
AU  - Dean, M.
AU  - Huttley, G.
AU  - O'Brien, S. J.
T2  - Nature Medicine
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1997///
VL  - 3
IS  - 10
SP  - 1052
EP  - 1053
AD  - Smith, M. W.: Science Applications International Corp., Frederick Cancer and Development Center, National Cancer Institute, Frederick MD 21702-1201, USA.
N1  - Accession Number: 19972010665.  Publication Type: Correspondence.  Language: English.  Number of References: 8 ref.
N2  - These correspondents previously reported an association between the CCR2-641 chemokine receptor mutation and delayed onset of AIDS. Michael, et al. (Nature Medicine (1997) 3 1160) have now examined the San Francisco Mens' Health Study AIDS (SFMHS) cohort for CCR2 genotypes and in this issue of Nature Medicine report that they fail to detect the CCR2-641 association. It is suggested by Smith et al. that the most likely explanation for the inability of SFMHS to detect the CCR2-641 effect is the disposition of the cohort, which includes primarily seroprevalent patients and other aspects which could mask the effect.
KW  - acquired immune deficiency syndrome
KW  - chemokines
KW  - cytokines
KW  - disease course
KW  - effects
KW  - genetic polymorphism
KW  - genotypes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mutations
KW  - patients
KW  - receptors
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - disease progression
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010665&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA.
AU  - Soldan, S. S.
AU  - Berti, R.
AU  - Salem, N.
AU  - Secchiero, P.
AU  - Flamand, L.
AU  - Calabresi, P. A.
AU  - Brennan, M. B.
AU  - Maloni, H. W.
AU  - McFarland, H. F.
AU  - Lin HunChi
AU  - Patnaik, M.
AU  - Jacobson, S.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1997///
VL  - 3
IS  - 12
SP  - 1394
EP  - 1397
AD  - Soldan, S. S.: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 5B-16, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982009176.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9007-49-2. 
N2  - Recently, HHV-6 has been reported to be present in active multiple sclerosis (MS) plaques. In order to extend these observations, sera from 36 MS patients (22 with relapsing-remitting MS (RRMS) and 14 with chronic progressive MS (CPMS)), 31 patients with other neurological diseases, 21 with other autoimmune diseases, and 14 asymptomatic healthy controls, were obtained from a medical centre in Maryland, USA, and were assayed for IgM antibodies to HHV-6 early antigen (p41/38) by enzyme immunoassay [date not given]. There was a highly significant difference in the anti-HHV-6 IgM response to HHV-6 p41/38, particularly between the RRMS group and normal controls (P&lt;0.0011). In addition, studies to detect active HHV-6 DNA in patient sera using a nested PCR technique revealed that no HHV-6 DNA could be amplified from the serum of 47 non-MS patients, but that positive HHV-6 DNA signals could be demonstrated in 15 of 50 (30%) MS patients (14 RRMS, 1 CPMS) (P&lt;0.0001). It is concluded that these studies support the hypothesis that HHV-6 plays a role in the aetiology of MS.
KW  - aetiology
KW  - antibodies
KW  - detection
KW  - DNA
KW  - human diseases
KW  - IgM
KW  - multiple sclerosis
KW  - nervous system diseases
KW  - serology
KW  - seroprevalence
KW  - viral antigens
KW  - viral diseases
KW  - Maryland
KW  - USA
KW  - human herpesvirus 6
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - causal agents
KW  - deoxyribonucleic acid
KW  - etiology
KW  - neuropathy
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009176&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of HMBP-2, a DNA-binding protein that binds to HIV-1 LTR when only one of the three Sp1 sites is methylated.
AU  - Shao, W.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1997///
VL  - 4
IS  - 1
SP  - 39
EP  - 46
AD  - Shao, W.: SAIC, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19972005120.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 77-78-1. 
N2  - HIV-1 methylation binding protein-1 (HMBP-1) (formerly called HMBP) is a protein found in human cell nuclei that binds with enhanced affinity to the fragment of the HIV-1 long terminal repeat sequence (LTR) containing 3 Sp1 sites when all 3 sites are methylated. HMBP-2 is another protein present in the nuclei of human T helper lymphocytes and HeLa cells that binds to the HIV-1 LTR. HMBP-2 binds preferentially to the same region of the HIV-1 LTR as does HMBP-1, but HMBP-2 binds best when only one of the 3 Sp1 sites is methylated. HMBP-2 can be separated from HMBP-1 chromatographically, and dimethyl sulfate (DMS) methylation interference analysis indicates that their binding sites are not identical. HMBP-2 represents a novel protein factor capable of binding to a partially methylated region of the HIV-1 LTR.
KW  - dimethyl sulfate
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interference
KW  - lymphocytes
KW  - microbiology
KW  - nuclei
KW  - proteins
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - cell nuclei
KW  - dimethyl sulphate
KW  - genomic structure
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - LTR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005120&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.
AU  - Lucey, D. R.
AU  - Pinto, L. A.
AU  - Bethke, F. R.
AU  - Rusnak, J.
AU  - Melcher, G. P.
AU  - Hashemi, F. N.
AU  - Landay, A. L.
AU  - Kessler, H. A.
AU  - Paxton, R. J.
AU  - Grabstein, K.
AU  - Shearer, G. M.
JO  - Clinical and Diagnostic Laboratory Immunology
JF  - Clinical and Diagnostic Laboratory Immunology
Y1  - 1997///
VL  - 4
IS  - 1
SP  - 43
EP  - 48
SN  - 1071-412X
AD  - Lucey, D. R.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972002827.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2. 
N2  - The effects of IL-15 on induction of lymphokine-activated killer (LAK) cells, gamma interferon (IFN-γ) production from HIV-positive peripheral blood mononuclear cells (PBMCs), and HIV production from PBMCs were studied. Induction of LAK cells by IL-15 was found in eight of eight HIV-positive donors. Incubation of PBMCs from some donors with IL-15 (1, 10, 50, and 100 ng/ml) induced production of IFN-γ. The effect of IL-15 was compared with that of IL-2 on HIV replication in PBMCs from five HIV-positive patients and four HIV-negative donors whose PBMCs were infected in vitro with HIV. Levels of HIV p24 antigen were moderately lower in the presence of 10 ng of IL-15 per ml than with 10 ng of IL-2 per ml, but they were similar for 100 and 500 ng of each cytokine per ml. It is concluded that IL-15 can induce LAK cell activity in HIV-seropositive patients and can stimulate IFN-γ production from PBMCs of some donors. IL-15 stimulates levels of HIV production from PBMCs which are similar to or moderately lower than those obtained with IL-2, depending on cytokine concentration.
KW  - antigens
KW  - B lymphocytes
KW  - blood
KW  - cells
KW  - clinical aspects
KW  - core protein p24
KW  - cytokines
KW  - donors
KW  - effects
KW  - hiv-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - in vitro
KW  - interferon
KW  - interleukin 15
KW  - interleukin 2
KW  - interleukins
KW  - patients
KW  - replication
KW  - T lymphocytes
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - B cells
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - p24
KW  - p24 antigen
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002827&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - A minor groove binding track in reverse transcriptase.
AU  - Bebenek, K.
AU  - Beard, W. A.
AU  - Darden, T. A.
AU  - Li LePing
AU  - Prasad, R.
AU  - Luxon, B. A.
AU  - Gorenstein, D. G.
AU  - Wilson, S. H.
AU  - Kunkel, T. A.
T2  - Nature Structural Biology
JO  - Nature Structural Biology
JF  - Nature Structural Biology
Y1  - 1997///
VL  - 4
IS  - 3
SP  - 194
EP  - 197
SN  - 1072-8368
AD  - Bebenek, K.: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19972003798.  Publication Type: Correspondence.  Language: English.  Number of References: 27 ref. Registry Number: 9068-38-6. 
N2  - Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track.
KW  - binding
KW  - HIV-1 infections
KW  - human diseases
KW  - interactions
KW  - microbiology
KW  - reverse transcriptase
KW  - structural genes
KW  - structure
KW  - synthesis
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - RT gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003798&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.
AU  - Cai, M. L.
AU  - Zheng, R.
AU  - Caffrey, M.
AU  - Craigie, R.
AU  - Clore, G. M.
AU  - Gronenborn, A. M.
JO  - Nature Structural Biology
JF  - Nature Structural Biology
Y1  - 1997///
VL  - 4
IS  - 7
SP  - 567
EP  - 577
SN  - 1072-8368
AD  - Cai, M. L.: Laboratories of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.
N1  - Accession Number: 19972009669.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref. Registry Number: 9007-49-2, 7440-66-6. 
N2  - The solution structure of the N-terminal zinc binding domain (residues 1-55; IN1-55) of HIV-1 integrase has been solved by NMR spectroscopy. IN1-55 is dimeric, and each monomer comprises four helices with the zinc tetrahedrally coordinated to His 12, His 16, Cys 40, and Cys 43. IN1-55 exists in two interconverting conformational states that differ with regard to the coordination of the two histidine side chains to zinc. The different histidine arrangements are associated with large conformational differences in the polypeptide backbone (residues 9-18) around the coordinating histidines. The dimer interface is predominantly hydrophobic and is formed by the packing of the N-terminal end of helix 1, and helices 3 and 4. The monomer fold is remarkably similar to that of a number of helical DNA binding proteins containing a helix-turn-helix (HTH) motif with helices 2 and 3 of IN1-55 corresponding to the HTH motif. In contrast to the DNA binding proteins where the second helix of the HTH motif is employed for DNA recognition, IN1-55 uses this helix for dimerization.
KW  - binding
KW  - DNA
KW  - DNA binding proteins
KW  - enzymes
KW  - human diseases
KW  - microbiology
KW  - polypeptides
KW  - proteins
KW  - structural genes
KW  - structure
KW  - zinc
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - dimers
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009669&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiology of squamous cell conjunctival cancer.
AU  - Sun, E. C.
AU  - Fears, T. R.
AU  - Goedert, J. J.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1997///
VL  - 6
IS  - 2
SP  - 73
EP  - 77
SN  - 1055-9965
AD  - Sun, E. C.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA.
N1  - Accession Number: 19972009046.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Public Health
N2  - To examine the relationship between UVB radiation exposure and squamous cell carcinoma of the conjunctiva (SCCC), US population-based age-adjusted incidence rates of SCCC and of conjunctival melanoma and squamous cell cancer of the eyelid reported during 1973-1990, were plotted against the UVB insolation of each registry site. Incidence data were examined further for patterns of second primary cancers among people with SCCC. SCCC was rare in the USA, with an incidence rate of 0.03 per 100 000 persons, although the rate was approximately 5-fold higher among males and whites. Regression analysis suggested a link between UVB exposure and SCCC rates (β=2.25; r=0.58) that was as strong as that for squamous cell carcinoma of the eyelid (β=2.73; r=0.62) and much stronger than for conjunctival melanoma (β=0.28; r=0.02). Risk of a second malignancy after SCCC was not increased overall (20 observed and 14.1 expected), although a significant excess of salivary gland cancer (4 observed and 0.03 expected) and a borderline excess of lung cancer (6 observed and 2.4 expected) were noted. These observations suggest that UV radiation contributes to SCCC development. Additional research is needed to define the other exposures and host susceptibility that may interact with UV-related genetic damage in the multifactorial development of this rare neoplasm.
KW  - aetiology
KW  - carcinoma
KW  - conjunctiva
KW  - epidemiology
KW  - exposure
KW  - eyelids
KW  - eyes
KW  - human diseases
KW  - melanoma
KW  - neoplasms
KW  - radiation
KW  - risk factors
KW  - solar radiation
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - causal agents
KW  - conjunctival cancer
KW  - etiology
KW  - sunlight
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Health and the Environment (VV500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009046&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Kuru: forty years later, a historical note.
AU  - Liberski, P. P.
AU  - Gajdusek, D. C.
JO  - Brain Pathology
JF  - Brain Pathology
Y1  - 1997///
VL  - 7
IS  - 1
SP  - 555
EP  - 560
AD  - Liberski, P. P.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA.
N1  - Accession Number: 19972008875.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Subject Subsets: Tropical Diseases
KW  - clinical aspects
KW  - epidemiology
KW  - human diseases
KW  - kuru
KW  - prion diseases
KW  - reviews
KW  - Oceania
KW  - Papua new guinea
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - New Guinea
KW  - Melanesia
KW  - Australasia
KW  - Oceania
KW  - Pacific Islands
KW  - clinical picture
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008875&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cellular proteins in HIV virions.
AU  - Ott, D. E.
JO  - Reviews in Medical Virology
JF  - Reviews in Medical Virology
Y1  - 1997///
VL  - 7
IS  - 3
SP  - 167
EP  - 180
SN  - 1052-9276
AD  - Ott, D. E.: AIDS Vaccine Program, SAIC/Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972009414.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref.
N2  - HIV-1 virions contain both virus-encoded and cellular proteins. Recent advances in the detection, isolation, and functional characterization of host proteins incorporated in the virion have begun to furnish new insights into the interactions between virus and cell. The acquisition of host proteins by HIV-1 may also influence viral pathology in vivo. This article reviews the detection and analysis of host proteins found in HIV-1 particles and presents some potential roles that these proteins might play in the biology of the virus.
KW  - cells
KW  - characterization
KW  - detection
KW  - HIV-1 infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - major histocompatibility complex
KW  - microbiology
KW  - pathogenesis
KW  - pathology
KW  - proteins
KW  - reviews
KW  - surface proteins
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - membrane proteins
KW  - virions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - AIDS: decline and fall of immune surveillance?
AU  - Feinberg, M. B.
AU  - McLean, A. R.
JO  - Current Biology
JF  - Current Biology
Y1  - 1997///
VL  - 7
IS  - 3
SP  - R136
EP  - R140
SN  - 0960-9822
AD  - Feinberg, M. B.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972003399.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref.
N2  - The interaction of HIV-1 with its host is discussed, in light of recent observations which cast doubt on the view that cytotoxic T cells play a key role in keeping HIV-1 infection in check, and that it is this mechanism of immune surveillance that permits progression to AIDS. This article discusses the questions of how HIV-1 maintains a chronic persistent infection, and why the immune system, while apparently active in its response to the virus, is ultimately unable to control HIV-1 infection effectively and protect the infected individual from progression to AIDS.
KW  - acquired immune deficiency syndrome
KW  - cell mediated immunity
KW  - cytotoxic t lymphocytes
KW  - disease course
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cellular immunity
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin intake: a possible determinant of plasma homocyst(e)ine among middle-aged adults.
AU  - Shimakawa, T.
AU  - Nieto, F. J.
AU  - Malinow, M. R.
AU  - Chambless, L. E.
AU  - Schreiner, P. J.
AU  - Szklo, M.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1997///
VL  - 7
IS  - 4
SP  - 285
EP  - 293
SN  - 1047-2797
AD  - Shimakawa, T.: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethedsa, MD, USA.
N1  - Accession Number: 19971409106.  Publication Type: Journal Article.  Language: English.  Number of References: 66 ref. Registry Number: 7440-70-2, 68-19-9, 59-30-3, 6027-13-0, 7439-89-6, 7723-14-0, 65-23-6, 83-88-5, 59-43-8.  Subject Subsets: Human Nutrition
N2  - To examine the relationship between vitamin intakes and plasma homocysteine, dietary intake data was examined from a case-control study of 322 middle-aged individuals with atherosclerosis in the carotid artery and 318 control subjects without evidence of this disease. All these individuals were selected from a probability sample of 15 800 men and women who participated in the Atherosclerosis Risk in Communities (ARIC) Study, USA. Plasma homocysteine was inversely associated with intakes of folate, vitamin B6 and vitamin B12 (controls only for this vitamin). Among non-users of vitamin supplement products, on average each tertile increase in intake of these vitamins was associated with 0.4 to 0.7 µmol/litre decrease in plasma homocysteine. There were inverse associations between plasma homocysteine and thiamin, riboflavin, calcium, phosphorus and iron. There were no significant associations between methionine and protein intake and plasma homocysteine. In almost all analyses, cases and controls showed similar associations between dietary variables and plasma homocysteine. Plasma homocysteine among users of vitamin supplement products was 1.5 µmol/litre lower than that among non-users.
KW  - adults
KW  - atherosclerosis
KW  - blood
KW  - calcium
KW  - consumption
KW  - cyanocobalamin
KW  - diet
KW  - folic acid
KW  - homocysteine
KW  - iron
KW  - men
KW  - minerals
KW  - nutrition surveys
KW  - phosphorus
KW  - pyridoxine
KW  - riboflavin
KW  - risk factors
KW  - supplements
KW  - thiamin
KW  - trace elements
KW  - vitamin b12
KW  - vitamins
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aneurin
KW  - arteriosclerosis
KW  - cobalamin
KW  - folacin
KW  - folate
KW  - microelements
KW  - nutritional surveys
KW  - thiamine
KW  - United States of America
KW  - vitamin B1
KW  - vitamin B2
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heterocyclic amines, cytochrome P4501A2, and N-acetyltransferase: issues involved in incorporating putative genetic susceptibility markers into epidemiological studies.
AU  - Sinha, R.
AU  - Caporaso, N.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1997///
VL  - 7
IS  - 5
SP  - 350
EP  - 356
SN  - 1047-2797
AD  - Sinha, R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA.
N1  - Accession Number: 19971411227.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 9035-51-2.  Subject Subsets: Human Nutrition
N2  - Heterocyclic amines (HCAs), which are found mainly in well-cooked meat, require metabolic activation to function as mutagens and animal carcinogens. Enzymes such as cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) perform this task and are subject to interindividual variation. The source of this variation may be genetic, as in the case of NAT2, or genetic and environmental as with CYP1A2. The effects of HCAs on the NAT2 and CYP1A2 phenotypes were examined in 33 men and 33 women. The subjects consumed a low HCA-containing diet for 1 week followed by a high HCA diet for the subsequent week. The subjects were phenotyped for CYP1A2 and NAT2 at the time of entry into the study (free-living), 1 week later (end of low-HCA or low-induction diet) and 2 weeks later (end of high-HCA or high-induction diet). Consistent with genetic sources of variability, NAT2 showed little effect of a high-HCA diet and exhibited high intraindividual correlation. CYP1A2, in contrast, was induced by a high-HCA diet and exhibited a more modest intraindividual correlation. It is concluded that incorporating putative genetic susceptibility makers in population studies requires consideration of issues of induction and inhibition of metabolizing enzymes, and effects of covariates.
KW  - amines
KW  - carcinogens
KW  - cooking
KW  - cytochrome P-450
KW  - enzyme activity
KW  - genetics
KW  - heterocyclic nitrogen compounds
KW  - markers
KW  - meat
KW  - mutagens
KW  - susceptibility
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - activation
KW  - N-acetyltransferase
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene.
AU  - Lee, C. G. L.
AU  - Jeang KuanTeh
AU  - Martin, M. A.
AU  - Pastan, I.
AU  - Gottesman, M. M.
JO  - Antisense and Nucleic Acid Drug Development
JF  - Antisense and Nucleic Acid Drug Development
Y1  - 1997///
VL  - 7
IS  - 5
SP  - 511
EP  - 522
AD  - Lee, C. G. L.: Laboratory of Cell Biology, Bldg 37, Rm 1B22, National Cancer Institute, NIH, 37 Convent Drive, MSC 4255, Bethesda, MD 20895-4255, USA.
N1  - Accession Number: 19982000166.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 63231-63-0. 
N2  - Harvey sarcoma-based retroviral vectors encoding the multidrug resistance gene (MDR1) multidrug transporter with a hammerhead ribozyme targeted to highly conserved sequences within the HIV-1 U5 LTR segment have been constructed in a bicistronic format. The internal ribosome entry site (IRES) from encephalomyocarditis virus was used to initiate translation of the MDR1 mRNA. The ribozyme remained functional despite being tethered to MDR1. Long-term, high-level expression of both the ribozyme and MDR1, as evident by RT-PCR and FACS analysis, was observed in a human T cell line containing the construct selected with vincristine, a cytotoxic substrate for the multidrug transporter.
KW  - antiviral agents
KW  - cell lines
KW  - cytotoxicity
KW  - drug resistance
KW  - enzymes
KW  - genes
KW  - genomes
KW  - HIV-1 infections
KW  - human diseases
KW  - multiple drug resistance
KW  - RNA
KW  - T lymphocytes
KW  - translation
KW  - treatment
KW  - vectors
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - conserved sequences
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - ribozymes
KW  - RNA translation
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors and early detection of lung cancer in a cohort of Chinese tin miners.
AU  - Qiao YouLin
AU  - Taylor, P. R.
AU  - Yao ShuXiang
AU  - Erozan, Y. S.
AU  - Luo XueChang
AU  - Barrett, M. J.
AU  - Yan QingYuan
AU  - Giffen, C. A.
AU  - Huang ShaoQiang
AU  - Maher, M. M.
AU  - Forman, M. R.
AU  - Tockman, M. S.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1997///
VL  - 7
IS  - 8
SP  - 533
EP  - 541
SN  - 1047-2797
AD  - Qiao YouLin: Cancer Prevention Studies Branch, National Cancer Institute, National Institute of Health, Executive Plaza North, Suite 211, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19982003900.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 7440-38-2, 10043-92-2, 7440-31-5.  Subject Subsets: Tropical Diseases
N2  - In order to examine risk factors and establish a biological specimen and data bank for the study of early markers of lung cancer a dynamic cohort study was designed using an ongoing lung cancer screening programme among radon- and arsenic-exposed tin miners in Yunnan, China. Through the first 4 years of the study (1992-95), 8346 miners aged ≥40 years with &gt;10 years of occupational exposure were enrolled, risk factors were assessed, annual sputum and chest radiographs were obtained and biological specimens were collected. 243 new lung cancer cases were identified by the end of 1995. Radon and arsenic exposures were the predominant risk factors (4-fold increased risk in the highest quartile of radon exposure and a nearly 5-fold relative risk for highest quartile of arsenic exposure), but lung cancer risk was also associated with chronic bronchitis and silicosis (age adjusted relative risks, 1.73 and 1.46 respectively), as well as a number of measures of exposure to tobacco smoke, including early age of first use, duration, and cumulative exposure (relative risk, 1.59 for current tobacco smoking).
KW  - arsenic
KW  - bronchitis
KW  - human diseases
KW  - lung cancer
KW  - lungs
KW  - miners
KW  - neoplasms
KW  - occupational hazards
KW  - radon
KW  - risk factors
KW  - silicosis
KW  - tin
KW  - tobacco smoking
KW  - China
KW  - Yunnan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - South Western China
KW  - China
KW  - cancers
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cause-specific mortality in women receiving hormone replacement therapy.
AU  - Schairer, C.
AU  - Adami, H. O.
AU  - Hoover, R.
AU  - Persson, I.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1997///
VL  - 8
IS  - 1
SP  - 59
EP  - 65
SN  - 1044-3983
AD  - Schairer, C.: Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, USA.
N1  - Accession Number: 19972008090.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 50-28-2.  Subject Subsets: Public Health
N2  - To assess the risks and benefits of menopausal hormone replacement therapy, a 23 246-member, population-based cohort of Swedish women who were prescribed menopausal oestrogens for a mean of 8.6 years, was followed for mortality. Compared with the general population, the standardized mortality ratio for all-cause mortality in this cohort was 0.77 (95% confidence limits = 0.73, 0.81). Deaths in each of the 12 major categories of causes of death except for injuries occurred 12-86% less frequently than expected. Four specific causes of death were examined in detail according to the type of hormone prescribed, namely weak oestrogens (primarily oestriol), more potent oestrogens (primarily oestradiol and conjugated oestrogens) in combination with a progestin, and more potent oestrogens without a progestin. Mortality from endometrial cancer was not related to the prescription of weak oestrogens or an oestrogen-progestin combination, but mortality was 40% higher in women prescribed more potent oestrogens without a progestin. Women prescribed weak oestrogens, more potent oestrogens and the combined oestrogen-progestin regimen were at reduced risk of death from ischaemic heart disease (standardized mortality ratios of 0.7, 0.6 and 0.4, respectively). The more potent oestrogens and the oestrogen-progestin combination were associated with a marked reduction in risk of intracerebral haemorrhage (standardized mortality ratios of 0.4 and 0.6, respectively) and "other" cerebrovascular disease, but not other types of stroke. The concern that use of progestins would lead to psychic disorders related to suicide was unsupported by these results. Breast cancer results were reported separately. These results provided little evidence of an adverse effect of the combined oestrogen-progestin regimen in comparison with oestrogens alone on mortality. It is concluded that both selection factors and biology may contribute to the almost across-the board-reduction in mortality associated with hormone replacement therapy.
KW  - breast cancer
KW  - cardiovascular diseases
KW  - causes of death
KW  - cerebrovascular disorders
KW  - death
KW  - endometrial cancer
KW  - estradiol
KW  - haemorrhage
KW  - heart
KW  - heart diseases
KW  - hormone replacement therapy
KW  - mortality
KW  - myocardial ischaemia
KW  - neoplasms
KW  - prescriptions
KW  - risk factors
KW  - trauma
KW  - women
KW  - Europe
KW  - Sweden
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - bleeding
KW  - cancers
KW  - coronary diseases
KW  - death rate
KW  - hemorrhage
KW  - ischaemic heart disease
KW  - myocardial ischemia
KW  - oestradiol
KW  - traumas
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Women (UU500) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reproductive factors, oral contraceptive use, and risk of colorectal cancer.
AU  - Troisi, R.
AU  - Schairer, C.
AU  - Chow WongHo
AU  - Schatzkin, A.
AU  - Brinton, L. A.
AU  - Fraumeni, J. F., Jr.
JO  - Epidemiology
JF  - Epidemiology
Y1  - 1997///
VL  - 8
IS  - 1
SP  - 75
EP  - 79
SN  - 1044-3983
AD  - Troisi, R.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7374, USA.
N1  - Accession Number: 19972008091.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Public Health
N2  - Among 57 529 women (aged 31-90 years) from the USA, who volunteered for a nationwide breast cancer screening programme during 1973-80, 154 pathologically confirmed cases of colon cancer and 49 cases of rectal cancer were observed in up to 10 years of follow-up (388 555 person-years). Parity was not associated with risk of colorectal cancer (age-adjusted rate ratio for ≥4 children vs. no children = 1.0; 95% confidence interval (CI) 0.72-1.5), although decreases in proximal colon cancer and increases in distal colon cancer were observed among parous women. The effect of parity did not vary by age at diagnosis. There was no strong or consistent association for age at menarche, age at first birth, or age at natural menopause. In addition, oral contraceptive use, reflecting mainly past use, was unrelated to risk of colorectal cancer (rate ratio = 1.0; 95% CI 0.75-1.4). These results did not support the hypothesis that reproductive events or oral contraceptives influence the development of colorectal cancer.
KW  - colon
KW  - colorectal cancer
KW  - contraceptives
KW  - human diseases
KW  - mortality
KW  - neoplasms
KW  - oral contraceptives
KW  - parity
KW  - rectum
KW  - risk factors
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Women (UU500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutritional issues and HIV/AIDS: assessment and treatment strategies.
AU  - Walse, C.
AU  - Zafonte, M.
AU  - Muir Bowers, J.
JO  - Journal of the Association of Nurses in AIDS Care
JF  - Journal of the Association of Nurses in AIDS Care
Y1  - 1997///
VL  - 8
IS  - 6
SP  - 71
EP  - 80
AD  - Walse, C.: National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982000223.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
N2  - This article summarizes aetiologies of HIV-associated nutritional deficiencies, reviews important components of nutrition assessment (including nutrition-related side effects of approved medications commonly used in HIV disease), provides an overview of common nutritional problems and interventions, and lists some available nutritional resources.
KW  - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW  - adverse effects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nutrition
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse chromosome 5.
AU  - McAllister, K. A.
AU  - Ramachandran, S.
AU  - Haugen-Strano, A.
AU  - Fiedorek, F. T., Jr.
AU  - Wiseman, R. W.
JO  - Mammalian Genome
JF  - Mammalian Genome
Y1  - 1997///
VL  - 8
IS  - 7
SP  - 540
EP  - 541
SN  - 0938-8990
AD  - McAllister, K. A.: Laboratory of Molecular Carcingenesis, National Institute of Environmental Health Sciences, Triangle Park, North Carolina 27709, USA.
N1  - Accession Number: 19970107293.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2  - The mouse breast cancer 2 gene (Brca2) was mapped to Chr 5: centromere-D5Mit30-(1.26 ± 0.89)-D5Mit63-(1.90 ± 1.09)-D5Mit51/D5Mit101-IM-(1.26 ± 0.89)-Ipf1-(0.63 ± 0.63)-Brca2/D5Mit122/D5Mit144/D5Mit192/D5Mit286-telomere. A (TTTGG)8 simple sequence repeat was found in intron 10 of the mouse Brca2 gene (EMBL/GenBank accession number U89503).
KW  - biotechnology
KW  - breast cancer
KW  - chromosomes
KW  - gene mapping
KW  - neoplasms
KW  - nucleotide sequences
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - breast cancer susceptibility gene
KW  - cancers
KW  - DNA sequences
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of vitamin in differentiation and skin carcinogenesis.
AU  - Luca, L. M. de
AU  - Kosa, K.
AU  - Andreola, F.
JO  - Journal of Nutritional Biochemistry
JF  - Journal of Nutritional Biochemistry
Y1  - 1997///
VL  - 8
IS  - 8
SP  - 426
EP  - 437
SN  - 0955-2863
AD  - Luca, L. M. de: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19971411306.  Publication Type: Journal Article.  Language: English.  Number of References: 99 ref. Registry Number: 302-79-4, 68-26-8.  Subject Subsets: Human Nutrition
N2  - Vitamin A is reviewed under the headings: Retinoid metabolism; Retinoids and epithelial differentiation; Epithelial, cell type specific expression of retinoid receptor transcripts; Retinoid-steroid interactions in cervical epithelial differentiation; The two families of retinoid receptors; Speculations on orders of receptor interactions; Mutants of retinoic acid receptors and their biological consequences; and Chemoprevention of skin carcinogenesis by dietary retinoic acid.
KW  - carcinogenesis
KW  - cell differentiation
KW  - differentiation
KW  - epithelium
KW  - retinoic acid
KW  - retinoids
KW  - retinol
KW  - reviews
KW  - skin
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - cytodifferentiation
KW  - dermis
KW  - tretinoin
KW  - vitamin A
KW  - vitamin A acid
KW  - vitamin A alcohol
KW  - vitamin A compounds
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411306&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - The two faces of essential fatty acids.
AU  - Lands, W. E. M.
JO  - INFORM - International News on Fats, Oils and Related Materials
JF  - INFORM - International News on Fats, Oils and Related Materials
Y1  - 1997///
VL  - 8
IS  - 11
SP  - 1141
EP  - 1147
SN  - 0897-8026
AD  - Lands, W. E. M.: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19981406144.  Publication Type: Journal Article.  Language: English.  Number of References: 88 ref. Subject Subsets: Human Nutrition
N2  - This review, based on a talk at the 1997 American Oil Chemists' Society (AOCS) Annual meeting and Expo in Seattle, USA in May [1997], describes laboratory approaches to essential fatty acid research from a historical perspective, including investigations into the essential actions of fatty acids in membrane structures and in hormone formation (the "two faces" of essential fatty acids) and the role of n-3 and n-6 acids.
KW  - essential fatty acids
KW  - nutrition research
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406144&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of natural killer cells in innate resistance to protozoan infections.
AU  - Scharton-Kersten, T. M.
AU  - Sher, A.
JO  - Current Opinion in Immunology
JF  - Current Opinion in Immunology
Y1  - 1997///
VL  - 9
IS  - 1
SP  - 44
EP  - 51
SN  - 0952-7915
AD  - Scharton-Kersten, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970804526.  Publication Type: Journal Article.  Language: English.  Number of References: 86 ref. Subject Subsets: Protozoology
N2  - The role of natural killer (NK) cells as major effectors of innate resistance to protozoan parasites is reviewed in relation to work both in mice and in man. The principal mechanism by which NK cells control the growth of these pathogens is considered. Recent studies which have identified a series of positive and negative signals provided by cytokines and cellular interactions which regulate protozoa-induced NK cell function are discussed.
KW  - cytokines
KW  - natural killer cells
KW  - parasites
KW  - resistance
KW  - reviews
KW  - man
KW  - mice
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - invertebrates
KW  - general account
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804526&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection.
AU  - Weissman, D.
AU  - Fauci, A. S.
JO  - Clinical Microbiology Reviews
JF  - Clinical Microbiology Reviews
Y1  - 1997///
VL  - 10
IS  - 2
SP  - 358
EP  - 367
SN  - 0893-8512
AD  - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Drive, MSC-1576, Bethesda, MD 20892-1576, USA.
N1  - Accession Number: 19972006539.  Publication Type: Journal Article.  Language: English.  Number of References: 159 ref.
N2  - This review focuses on the role of dendritic cells in the initiation and propagation of viral replication, particularly in the context of future directions of research and therapeutic strategies.
KW  - cells
KW  - dendritic cells
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immune system
KW  - immunology
KW  - immunopathology
KW  - pathogenesis
KW  - replication
KW  - reviews
KW  - vaccines
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006539&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Response to purified chick embryo cell rabies vaccine administered intradermally for post-exposure prophylaxis.
AU  - Madhusudana, S. N.
AU  - Anand, P. N.
JO  - National Medical Journal of India
JF  - National Medical Journal of India
Y1  - 1997///
VL  - 10
IS  - 3
SP  - 115
EP  - 116
SN  - 0970-258X
AD  - Madhusudana, S. N.: National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
N1  - Accession Number: 19972009392.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Tropical Diseases
N2  - An intradermal regimen with purified chick embryo vaccine for post-exposure immunization of rabies was evaluated in 25 subjects from India who had nursed or casually handled a rabies patient. There was 100% seroconversion and all the subjects developed neutralizing antibody levels higher than the adequate level of 0.5 IU/ml. Only minor side-effects were observed in some subjects. The feasibility of using this regimen in routine practice is considered.
KW  - antibodies
KW  - disease prevention
KW  - human diseases
KW  - immunization
KW  - rabies
KW  - regimens
KW  - seroconversion
KW  - vaccines
KW  - Asia
KW  - India
KW  - Karnataka
KW  - man
KW  - rabies virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lyssavirus
KW  - Rhabdoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - immune sensitization
KW  - Mysore
KW  - post-exposure immunization
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009392&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Healthcare institutions as 'hot zones': emerging and re-emerging pathogens.
AU  - Henderson, D. K.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1997///
VL  - 10
IS  - 4
SP  - 310
EP  - 318
SN  - 0951-7375
AD  - Henderson, D. K.: Clinical Care, Warren A Magason Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982003804.  Publication Type: Journal Article.  Language: English.  Number of References: 129 ref. Subject Subsets: Public Health
N2  - Recent information about occupational and nosocomial pathogens is reviewed, analysing the potential for health care institutions to become "hot zones". Nosocomial risks to patients from Staphylococcus aureus, coagulase-negative staphylococci and vancomycin-resistant enterococci, and risks to patients and occupational risks to health care workers from drug resistant tuberculosis and blood borne pathogens are discussed. Prevention strategies are briefly considered.
KW  - bacterial diseases
KW  - drug resistance
KW  - health care workers
KW  - hospitals
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - nosocomial infections
KW  - occupational hazards
KW  - occupational health
KW  - opportunistic infections
KW  - risk factors
KW  - tuberculosis
KW  - Enterococcus
KW  - man
KW  - Mycobacterium tuberculosis
KW  - Staphylococcus aureus
KW  - Enterococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Staphylococcus
KW  - Staphylococcaceae
KW  - Bacillales
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - hospital infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003804&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leptospirosis.
AU  - Vinetz, J. M.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1997///
VL  - 10
IS  - 5
SP  - 357
EP  - 361
SN  - 0951-7375
AD  - Vinetz, J. M.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19982006347.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
N2  - This review focuses on recent developments in the epidemiology, clinical manifestations, pathogenesis, pathophysiology, taxonomy and diagnosis of leptospirosis, with a brief mention of current therapeutics and directions for vaccine development.
KW  - animal diseases
KW  - bacterial diseases
KW  - clinical aspects
KW  - diagnosis
KW  - drug therapy
KW  - epidemiology
KW  - human diseases
KW  - leptospirosis
KW  - pathogenesis
KW  - physiopathology
KW  - reviews
KW  - taxonomy
KW  - vaccine development
KW  - zoonoses
KW  - Leptospira
KW  - man
KW  - Leptospiraceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - chemotherapy
KW  - clinical picture
KW  - pathophysiology
KW  - systematics
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006347&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Potential new antifungal agents.
AU  - Groll, A. H.
AU  - Walsh, T. J.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1997///
VL  - 10
IS  - 6
SP  - 449
EP  - 458
SN  - 0951-7375
AD  - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201878.  Publication Type: Journal Article.  Language: English.  Number of References: 129 ref. Registry Number: 1400-61-9, 79404-91-4, 137234-62-9. 
N2  - Potential new antifungal agents are discussed including third generation azoles (voriconazole, SCH 56592), echinocandins and pneumocandins (cilofungin, LY 303366, L-743872), pradimicins and benanomicins, liposomal nystatin and nikkomycin Z. New emerging compounds and targets for drugs are also considered.
KW  - antifungal agents
KW  - azoles
KW  - cilofungin
KW  - echinocandins
KW  - liposomes
KW  - nystatin
KW  - pharmacodynamics
KW  - reviews
KW  - voriconazole
KW  - benanomicins
KW  - ceratocide
KW  - drug action
KW  - fungistats
KW  - L-743872
KW  - LY 303366
KW  - mechanism of drug action
KW  - nikkomycin Z
KW  - pneumocandins
KW  - pradimicins
KW  - SCH 56592
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201878&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of combination therapy with zidovudine and didanosine on neuropsychological functioning in patients with symptomatic HIV disease: a comparison of simultaneous and alternating regimens.
AU  - Brouwers, P.
AU  - Hendricks, M.
AU  - Lietzau, J. A.
AU  - Pluda, J. M.
AU  - Mitsuya, H.
AU  - Broder, S.
AU  - Yarchoan, R.
JO  - AIDS
JF  - AIDS
Y1  - 1997///
VL  - 11
IS  - 1
SP  - 59
EP  - 66
SN  - 0269-9370
AD  - Brouwers, P.: The HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972001600.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 69655-05-6, 30516-87-1. 
N2  - In this non-blinded clinical trial 38 patients with symptomatic HIV-1 disease, of whom 21 had evidence of CNS compromise at entry, were randomly assigned to alternating and simultaneous regimens of zidovudine and didanosine. After 12 weeks of therapy, overall significant improvements in memory and focused attention were seen on both regimens. These gains, however, were largely limited to those patients with HIV-1-associated CNS compromise at entry. Improvements were also noted in receptive vocabulary, reading, perceptual discrimination and reasoning, divided attention, motor strength, and in mood and affect. Improvements in those latter functions were generally of limited magnitude and were of comparable size for both compromised and non-compromised patients. There was no overall difference between the two drug regimens in the effects on CNS parameters. This supports the contention that the CNS constitutes a relatively independent compartment in terms of HIV disease and treatment.
KW  - acquired immune deficiency syndrome
KW  - AIDS dementia complex
KW  - antiviral agents
KW  - central nervous system
KW  - clinical aspects
KW  - combination therapy
KW  - didanosine
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - nervous system diseases
KW  - nucleosides
KW  - patients
KW  - regimens
KW  - symptoms
KW  - treatment
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - AZT
KW  - chemotherapy
KW  - clinical picture
KW  - CNS
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - multimodal treatment
KW  - neuropathy
KW  - neuropsychology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001600&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Early foscarnet failure in herpes simplex virus infection in a patient with AIDS.
AU  - Segal, B. H.
AU  - Engler, H. D.
AU  - Little, R.
AU  - Wilson, W. H.
AU  - Freifeld, A. G.
AU  - Chanock, S. J.
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1997///
VL  - 11
IS  - 4
SP  - 552
EP  - 553
SN  - 0269-9370
AD  - Segal, B. H.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19972003482.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref. Registry Number: 63585-09-1. 
N2  - This report describes a case of early treatment failure of foscarnet, in which new oral mucosal HSV-1 disease developed in a patient with AIDS within one week of starting high-dose foscarnet induction therapy for cytomegalovirus disease, despite in vitro susceptibility of the HSV isolate.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - case reports
KW  - drug resistance
KW  - drug therapy
KW  - foscarnet sodium
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - treatment
KW  - cytomegalovirus
KW  - Human herpesvirus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - chemotherapy
KW  - herpes simplex virus 1
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - trisodium phosphonoformate
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003482&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunologic and virologic evaluation after influenza vaccination of HIV-1-infected patients.
AU  - Fowke, K. R.
AU  - D'Amico, R.
AU  - Chernoff, D. N.
AU  - Pottage, J. C., Jr.
AU  - Benson, C. A.
AU  - Sha, B. E.
AU  - Kessler, H. A.
AU  - Landay, A. L.
AU  - Shearer, G. M.
JO  - AIDS
JF  - AIDS
Y1  - 1997///
VL  - 11
IS  - 8
SP  - 1013
EP  - 1021
SN  - 0269-9370
AD  - Fowke, K. R.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 4B17 Building 10, 9000 Rockville Pike, Bethesda MD 20892, USA.
N1  - Accession Number: 19972005235.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 63231-63-0. 
N2  - The present study was designed to determine the effect of immune activation, achieved by influenza vaccination, on plasma HIV RNA levels and immunological parameters including CD4 cell levels, antigen-stimulated T-cell function and apoptotic death of peripheral blood mononuclear cells. Thirty four HIV-infected individuals and nine uninfected controls were immunized with influenza vaccine and blood was collected at weeks 0, 2, 4, and 16. Plasma was isolated and used for HIV RNA and influenza-specific antibody quantifications. CD4 cell counts, activation and maturation markers of T-lymphocyte subsets were determined by flow cytometry. In vitro T-helper responses, spontaneous- and activation-induced cell death assays were also performed. Influenza-specific humoral and cellular immune responses correlated with CD4 count. Only in patients with CD4 counts &gt;300 × 106/l there was a modest increase in T-cell responses to influenza virus, which was less than control subjects, observed after vaccination. Immunization had no significant effect on CD4 counts or plasma viral levels in the HIV-positive patients. Baseline apoptosis inversely correlated with CD4 counts and directly correlated with viral load. Activation-induced apoptosis did not change appreciably after vaccination and spontaneous apoptosis increased only in the &lt;300 CD4 group. These results indicate that immune stimulation resulting from influenza vaccination did not significantly change the levels of plasma virus, CD4 cell counts, or activation-induced apoptosis in HIV-infected individuals, although an increase in the T-cell response to influenza and spontaneous apoptosis was observed in the &gt;300 and &lt;300 CD4 groups, respectively.
KW  - antibodies
KW  - apoptosis
KW  - blood plasma
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - cell mediated immunity
KW  - death
KW  - effects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - humoral immunity
KW  - immune response
KW  - immunization
KW  - immunology
KW  - immunostimulation
KW  - in vitro
KW  - influenza
KW  - leukocyte count
KW  - maturation
KW  - patients
KW  - responses
KW  - RNA
KW  - stimulation
KW  - T lymphocytes
KW  - vaccination
KW  - vaccines
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - cellular immunity
KW  - flu
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - plasma (blood)
KW  - ribonucleic acid
KW  - T cells
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005235&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Receptive and expressive language function of children with symptomatic HIV infection and relationship with disease parameters: a longitudinal 24-month follow-up study.
AU  - Wolters, P. L.
AU  - Brouwers, P.
AU  - Civitello, L.
AU  - Moss, H. A.
JO  - AIDS
JF  - AIDS
Y1  - 1997///
VL  - 11
IS  - 9
SP  - 1135
EP  - 1144
SN  - 0269-9370
AD  - Wolters, P. L.: National Cancer Institute, HIV/AIDS Malignancy Branch, 10 Center Drive, Building 10, 13N240, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19972005837.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
N2  - Children with symptomatic HIV infection were administered an age-appropriate standardized comprehensive language test and general cognitive measure prior to starting antiretroviral therapy (n=44) and again after 6 months (n=29) and 24 months (n=17). CD4 percentage and CT brain scans were also obtained at each evaluation. Expressive language was significantly more impaired than receptive language at the baseline, 6- and 24-month evaluations. No significant changes over time were found in receptive or expressive language from baseline to after 6 months of antiretroviral therapy, but despite treatment, language scores declined significantly between 6 and 24 months. Overall cognitive function, however, remained stable from baseline to 24 months. Age-adjusted CD4 percentage increased significantly over the initial 6 months, then remained stable. Overall CT brain scan severity ratings did not change significantly over 24 months. Expressive language was consistently more impaired than receptive language over 24 months, further supporting an earlier finding that expressive language was differentially affected by HIV in children with symptomatic disease. Both receptive and expressive language declined significantly after 24 months despite antiretroviral therapy, although overall cognitive function remained stable. Thus, functioning in some domains may be more vulnerable to the effects of HIV and global measures of cognitive ability may mask such differential changes in specific brain functions.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - CD4 antigens
KW  - children
KW  - clinical aspects
KW  - cognitive development
KW  - computed tomography
KW  - differential diagnosis
KW  - follow up
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - languages
KW  - paediatrics
KW  - relationships
KW  - speech
KW  - symptoms
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD4
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - mental development
KW  - pediatrics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005837&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Does umbilical cord blood polymerase chain reaction positivity indicate in utero (pre-labor) HIV infection?
AU  - Biggar, R. J.
AU  - Mtimavalye, L.
AU  - Justesen, A.
AU  - Broadhead, R.
AU  - Miley, W.
AU  - Waters, D.
AU  - Goedert, J. J.
AU  - Chiphangwi, J. D.
AU  - Taha, T. E.
AU  - Miotti, P. G.
JO  - AIDS
JF  - AIDS
Y1  - 1997///
VL  - 11
IS  - 11
SP  - 1375
EP  - 1382
SN  - 0269-9370
AD  - Biggar, R. J.: Department of Obstetrics and Gynaecology, Queen Elizabeth Central Hospital, Blantyre, Malawi. Correspondence address: Viral Epidemiology Branch, National Cancer Institute, EPN-434, 6130 Executive Blvd, Rockville, MD 20850, USA.
N1  - Accession Number: 19972007761.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9007-49-2.  Subject Subsets: Tropical Diseases
N2  - In 1994, infants born to HIV-infected women were enrolled in a study in Blantyre, Malawi. Birth weight and transmission risk factors from cord blood-positive infants were compared with cord blood-negative/HIV-positive infants on their first postnatal visit (4-7 weeks of age). Testing for HIV DNA on cord and peripheral blood was performed by polymerase chain reaction. Of 249 HIV-infected infants (overall transmission rate, 26%), 83 (33%) were cord blood-positive and 166 were initially cord blood-negative. The mean birth weight was 2.1% (59 g) lighter in cord blood-positive infants than initially cord blood-negative infants; initially cord blood-negative infants were 2.8% (80 g) lighter than uninfected infants born to HIV-infected women. There were no significant differences in the risk factors for infection between HIV-infected cord blood-positive and -negative infants; when transmission was increased, both HIV-infected cord blood-positive and -negative infants contributed to the increase in a similar proportion. It was concluded that umbilical cord blood positivity for HIV DNA did not identify a subset of in utero HIV-infected infants and suggested that HIV-infected cord blood-positive and -negative infants have similar timing and routes of HIV infection.
KW  - cord blood
KW  - diagnosis
KW  - DNA
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - infection
KW  - infections
KW  - maternal transmission
KW  - mothers
KW  - polymerase chain reaction
KW  - pregnancy
KW  - risk factors
KW  - transmission
KW  - women
KW  - Africa
KW  - Malawi
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - deoxyribonucleic acid
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - Nyasaland
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007761&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of serum level of some biological markers in normal bilharzial infected and patients with different types of cancer.
AU  - El-Houseini, M. E.
AU  - Abu-El-Zahaub, H. S. H.
AU  - Moharram, N. Z.
AU  - Amr, M. M.
AU  - El-Meniawy, F. A.
JO  - Journal of Tumor Marker Oncology
JF  - Journal of Tumor Marker Oncology
Y1  - 1997///
VL  - 12
IS  - 2
SP  - 141
EP  - 148
AD  - El-Houseini, M. E.: Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 19980802564.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 51-35-4, 9039-53-6.  Subject Subsets: Helminthology
N2  - Different proteolytic enzymes, including acid protease, collagenase and plasminogen activator, showed highly significant increases in serum levels in schistosomiasis and bladder, liver and breast cancer patients compared with healthy controls. A significant increase in hydroxyproline level was also found in the serum of bilharziasis and bladder, liver and breast cancer patients as compared to normal controls. The increases were greatest in liver and breast cancer patients but were also present to a lesser extent in bladder cancer and schistosomiasis patients.
KW  - breast cancer
KW  - disease markers
KW  - enzymes
KW  - helminths
KW  - human diseases
KW  - hydroxyproline
KW  - liver cancer
KW  - neoplasms
KW  - parasites
KW  - pathology
KW  - plasminogen activator
KW  - proteinases
KW  - schistosomiasis
KW  - serum
KW  - Egypt
KW  - man
KW  - Schistosoma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - bilharzia
KW  - bilharziasis
KW  - cancers
KW  - Misr
KW  - oxyproline
KW  - parasitic worms
KW  - proteases
KW  - schistosomosis
KW  - Strigeida
KW  - urokinase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802564&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The need for assays predictive of protection in development of malaria bloodstage vaccines.
AU  - Miller, L. H.
AU  - Good, M. F.
AU  - Kaslow, D. C.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1997///
VL  - 13
IS  - 2
SP  - 46
EP  - 47
AD  - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980800642.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Protozoology
N2  - Essential criteria for a successful vaccine against bloodstages of Plasmodium, and studies carried out in laboratory animals are briefly discussed. The problem of deciding when to proceed to human trials is then considered and the need for in vitro assays which correlate with protective immunity is stressed.
KW  - assays
KW  - clinical trials
KW  - erythrocytic stages
KW  - field tests
KW  - human diseases
KW  - immunity
KW  - immunization
KW  - in vitro
KW  - malaria
KW  - parasites
KW  - vaccine development
KW  - vaccines
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800642&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Primary prevention of NIDDM: a practical reality.
AU  - Bennett, P. H.
JO  - Diabetes/Metabolism Reviews
JF  - Diabetes/Metabolism Reviews
Y1  - 1997///
VL  - 13
IS  - 2
SP  - 105
EP  - 111
SN  - 0742-4221
AD  - Bennett, P. H.: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, USA.
N1  - Accession Number: 19971412424.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - This paper reviews the aetiology of non-insulin-dependent diabetes mellitus (NIDDM); the natural history of NIDDM; the development of NIDDM; the target populations of NIDDM prevention; evidence in favour of preventive measures; evidence for primary prevention; pharmacological intervention; and rationale for primary prevention of NIDDM.
KW  - aetiology
KW  - diabetes
KW  - prevention
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - causal agents
KW  - etiology
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412424&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The pathogenesis of chorioretinal disease in onchocerciasis.
AU  - Cooper, P. J.
AU  - Guderian, R. H.
AU  - Proaño, R.
AU  - Taylor, D. W.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1997///
VL  - 13
IS  - 3
SP  - 94
EP  - 98
AD  - Cooper, P. J.: Laboratory of Parasitic Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970804182.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Subject Subsets: Helminthology
N2  - The pathogenesis of onchocercal chorioretinopathy is reviewed under the headings: clinical pattern of chorioretinopathy; histology; epidemiology; possible pathogenic mechanisms (microfilariae in the retina and choroid, toxic secretions, autoimmunity, immune complex disease, ischaemic atrophy, nutritional factors, genetics).
KW  - eyes
KW  - helminths
KW  - human diseases
KW  - onchocerciasis
KW  - parasites
KW  - pathogenesis
KW  - pathology
KW  - retinopathy
KW  - reviews
KW  - man
KW  - Nematoda
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - chorioretinopathy
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804182&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reactivation of HIV type 1 in chronically infected chimpanzees following xenostimulation with human cells or with pulses of corticosteroid.
AU  - Shibata, R.
AU  - Siemon, C.
AU  - Rizvi, T. A.
AU  - Matano, T.
AU  - Satterfield, W. C.
AU  - Lane, H. C.
AU  - Martin, M. A.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1997///
VL  - 13
IS  - 5
SP  - 377
EP  - 381
SN  - 0889-2229
AD  - Shibata, R.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972004574.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
N2  - The administration of high-dose, 17-day courses of corticosteroids resulted in coordinate and transient increases of each of the 3 virus strains present in the original inoculum and elevation of HIV-1-specific ELISA antibody levels. Steroids administered to a second chimpanzee, chronically infected with a single HIV-1 isolate, also induced elevations of cell-associated virus. These results highlight the intimate relationship between immune system activation/immunosuppression and HIV replication in an animal model.
KW  - animal models
KW  - antibodies
KW  - corticoids
KW  - ELISA
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - immunopathology
KW  - relationships
KW  - replication
KW  - steroids
KW  - chimpanzees
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Pan
KW  - Pongidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - corticosteroids
KW  - enzyme linked immunosorbent assay
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004574&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased in vitro tetanus-induced production of HIV type 1 following in vivo immunization of HIV type 1-infected individuals with tetanus toxoid.
AU  - Ostrowski, M. A.
AU  - Stanley, S. K.
AU  - Justement, J. S.
AU  - Gantt, K.
AU  - Goletti, D.
AU  - Fauci, A. S.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1997///
VL  - 13
IS  - 6
SP  - 473
EP  - 480
SN  - 0889-2229
AD  - Ostrowski, M. A.: Laboratory of Immunoregulation, National Institutes of Health, Bldg 10, Rm 6A11, 10 Center Drive, MSC-1576, Bethesda, MD 20892-1576, USA.
N1  - Accession Number: 19972004669.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 308079-78-9. 
N2  - It has been previously demonstrated that immunization of HIV-1 infected individuals with the common recall antigen, tetanus, induced transient increases in plasma viraemia as well as an increased ability to isolate virus from CD8+ T cell-depleted peripheral blood mononuclear cells (PBMCs) under minimally stimulated culture conditions (IL-2 plus IL-4) postimmunization. In this study, HIV-1-infected individuals were immunized with tetanus toxoid and PBMCs were examined at multiple time points following immunization. Tetanus-induced production of virus was defined as an increased ability to isolate HIV-1 from CD8+ T cell-depleted PBMCs in vitro in the presence of tetanus antigen as opposed to no antigen or control antigen alone. Following immunization, in vitro tetanus-induced production of HIV-1 was observed in 8 of 13 (62%) patients compared to 2 of 13 (15%) patients prior to immunization. In 4 of these patients, virus could also be isolated from CD8+ T cell-depleted PBMCs in the presence of tetanus without the addition of any exogenous IL-2. Furthermore, virus could be isolated from the unfractionated PBMCs of 2 patients when tetanus antigen alone was added to the culture in the absence of added PHA or PHA blasts. HIV-1 was isolated predominantly from CD4+ T cells with a CD45RO+, CD25+ phenotype and was associated with a trend to elevated levels in culture supernatants of IFN-γ, IL-6, TNF-α, and IL-4. These findings have important implications with regard to the role of ongoing antigen-specific immune responses in the induction of HIV-1 expression in vivo.
KW  - antigens
KW  - blood plasma
KW  - CD4+ lymphocytes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunization
KW  - immunology
KW  - in vitro
KW  - interleukins
KW  - patients
KW  - phenotypes
KW  - tetanus
KW  - toxoids
KW  - tumour necrosis factor
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - cachectin
KW  - cachexin
KW  - CD4+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - lockjaw
KW  - plasma (blood)
KW  - T4 lymphocytes
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004669&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preliminary evidence for partial restoration of immune function in HIV type 1 infection with potent antiretroviral therapies: clues from the Fourth Conference on Retroviruses and Opportunistic Diseases.
AU  - Schnittman, S. M.
AU  - Fox, L.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1997///
VL  - 13
IS  - 10
SP  - 815
EP  - 818
SN  - 0889-2229
AD  - Schnittman, S. M.: Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Solar Bldg./2C22, 6003 Executive Blvd., Rockville, MD 20852-3823, USA.
N1  - Accession Number: 19972006871.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 13 ref.
N2  - The results of studies of potent antiretroviral combination therapies presented at the 4th Conference on Retroviruses and Opportunistic Infections held in Washington, D.C., USA, between 22 and 26 January, 1997, demonstrate that such therapies are capable of at least partially restoring the immune system that is damaged by infection with HIV-1. This includes evidence for the ability of potent therapies to begin to reverse the abnormalities of maturation, activation, and function that are attributable directly or indirectly to the CD4+ helper T lymphocyte population.
KW  - abnormalities
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - infections
KW  - lymphocytes
KW  - opportunistic infections
KW  - T lymphocytes
KW  - USA
KW  - Washington
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006871&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of human immunodeficiency virus and colony-stimulating factors on the production of interleukin 6 and tumor necrosis factor α by monocyte/macrophages.
AU  - Foli, A.
AU  - Saville, M. W.
AU  - May, L. T.
AU  - Webb, D. S. A.
AU  - Yarchoan, R.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1997///
VL  - 13
IS  - 10
SP  - 829
EP  - 839
SN  - 0889-2229
AD  - Foli, A.: Correspondence address [Yarchoan, R.] Bldg 10, Rm 12N226, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972006873.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref. Registry Number: 308079-78-9. 
N2  - It was observed that, in the absence of endotoxin or cytokines, monocyte/macrophages (M/Ms) productively infected by HIV do not produce detectable interleukin 6 (IL-6) or tumour necrosis factor-α (TNF-α). However, granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that enhances HIV replication in M/Ms and is frequently used to propagate monocytotropic strains of HIV, can induce the relatively long-term production of IL-6 (up to 47 U/ml) and TNF-α (up to 47 pg/ml) by M/Ms, even in the absence of HIV. Also, HIV induced production of a relatively small (≤9 U/ml) quantity of IL-6 in M/Ms stimulated with macrophage-colony stimulating factor (M-CSF). Finally, while highly concentrated HIV induced production of both cytokines by either M/Ms or peripheral blood mononuclear cells (PBMCs), this production was almost completely eliminated when care was taken to avoid contamination of HIV by endotoxin. These data suggest that the excess IL-6 and TNF-α in HIV-infected patients does not simply result from their production by HIV-infected M/Ms and that alternative mechanisms are involved in this process.
KW  - colony stimulating factor
KW  - contamination
KW  - cytokines
KW  - endotoxins
KW  - human immunodeficiency viruses
KW  - immunology
KW  - interleukin 6
KW  - interleukins
KW  - necrosis
KW  - patients
KW  - replication
KW  - strains
KW  - tumour necrosis factor
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - cachectin
KW  - cachexin
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - long term
KW  - mechanisms
KW  - mononuclear cells
KW  - peripheral blood
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006873&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery.
AU  - Rey-Ferro, M.
AU  - Castaño, R.
AU  - Orozco, O.
AU  - Serna, A.
AU  - Moreno, A.
JO  - Nutrition
JF  - Nutrition
Y1  - 1997///
VL  - 13
IS  - 10
SP  - 878
EP  - 881
AD  - Rey-Ferro, M.: Gastrointestinal Surgery and Endoscopy Program, National Cancer Institute, Universidad Nacional, Santafé de Bogotá, Colombia.
N1  - Accession Number: 19981401009.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - Blood samples were taken before and 5 days after surgery from 22 men and 18 women aged 54±14 years with gastric cancer at the National Cancer Institute in Bogotá, Colombia. Mononuclear cell typing was done by flow cytometry allowing a bicolor analysis. Nutritional evaluation was obtained through measurement of albumin levels, average weight loss and nutritional risk index (NRI). Half of the malignancies were localized to the middle and lower third of the stomach: stage I, 17.55%; stage II, 10%; stage III, 55%; and stage IV, 17.5%. 20 subtotal gastrectomies, 11 total gastrectomies, 7 gastrojejunostomies and 2 oesophagogastrectomies with D1 and D2-D3 lymph node resection were performed. A postoperative morbidity of 22.5% and a mortality of 7.5% were observed. A preoperative cellular immunosuppression was identified, with a helper lymphocyte (CD4) to suppressor/cytotoxic lymphocyte (CD8) ratio of 1.38 normal value (NV&gt;1.5), which increased according to the stage of the disease. Patients who died presented with a significantly greater preoperative cellular immunosuppression than those who survived. Postoperative mortality correlated significantly with hypoalbuminemia. In those who died, weight loss was greater [not significant] than in those who survived. Patients with severe malnutrition had greater postoperative mortality according to the NRI. It is concluded that severe preoperative cellular immunosuppression (CD4/CD8 &lt;1), hypoalbuminaemia, weight loss and severe NRI have a positive predictive value for mortality in patients with gastric cancer.
KW  - gastrectomy
KW  - immune competence
KW  - immune response
KW  - malnutrition
KW  - morbidity
KW  - mortality
KW  - neoplasms
KW  - nutritional state
KW  - serum albumin
KW  - stomach
KW  - surgery
KW  - weight losses
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - death rate
KW  - immunity reactions
KW  - immunocompetence
KW  - immunological competence
KW  - immunological reactions
KW  - nutritional status
KW  - stomach removal
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Didanosine but not high doses of hydroxyurea rescue pigtail macaque from a lethal dose of SIVsmmpbj14.
AU  - Lori, F.
AU  - Gallo, R. C.
AU  - Malykh, A.
AU  - Cara, A.
AU  - Romano, J.
AU  - Markham, P.
AU  - Franchini, G.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1997///
VL  - 13
IS  - 13
SP  - 1083
EP  - 1088
SN  - 0889-2229
AD  - Lori, F.: Basic Research Laboratory, National Cancer Institute, 37 Convent Drive, Bldg 37, Rm. 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972008649.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 69655-05-6, 127-07-1, 63231-63-0. 
N2  - It has been previously reported that hydroxyurea (HU) displays anti-HIV-1 activity and potentiates the antiviral effects of didanosine (ddI) in vitro. To assess the antiviral efficacy of HU in an animal model, the effects of HU and ddI, either individually or as combination therapy, were tested in a model using infection of pigtail macaque with the acutely fatal variant SIVsmmpbj14. At the high dosage used (100 mg/kg/day), HU monotherapy failed to protect the exposed animals from viral infection and death, which occurred within 10 days postinoculation. However, both of the ddI-treated animals (5 mg/kg/day) survived the SIVsmmpbj14 lethal dose and displayed a reduction in viral load (undetectable SIV RNA or p27gag) in the primary phase of infection. Of the animals treated with the combination of drugs, one died at day 18 after infection and failed to seroconvert to viral antigens. These data suggest that a high dose of HU monotherapy does not protect against death induced by SIVsmmpbj14. However, lower doses of HU as monotherapy or combination therapy deserve further evaluation for their therapeutic effects.
KW  - antiviral agents
KW  - antiviral properties
KW  - combination therapy
KW  - didanosine
KW  - drug therapy
KW  - experimental infections
KW  - hydroxycarbamide
KW  - laboratory animals
KW  - RNA
KW  - treatment
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - Macaca
KW  - simian immunodeficiency virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anti-viral properties
KW  - chemotherapy
KW  - combined modality therapy
KW  - dideoxyinosine
KW  - human immunodeficiency virus type 1
KW  - hydroxyurea
KW  - multimodal treatment
KW  - ribonucleic acid
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Blood collection on filter paper: a practical approach to sample collection for studies of perinatal HIV transmission.
AU  - Biggar, R. J.
AU  - Miley, W.
AU  - Miotti, P.
AU  - Taha, T. E.
AU  - Butcher, A.
AU  - Spadoro, J.
AU  - Waters, D.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1997///
VL  - 14
IS  - 4
SP  - 368
EP  - 373
AD  - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, EPN-434, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19972004528.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
N2  - In this study, 15 810 filter paper cards with dried blood spots were collected. Infants were seen at age 6 and 12 weeks, and PCR was routinely done in duplicate on each sample. Of 186 negative controls (infants born to HIV-negative women), 2 (1.1%) had a single strongly reactive PCR result; the repeated duplicates were both negative. In contrast, all 24 known positive samples were strongly positive in both tests. Results were available from 1976 duplicate tests on 1235 infants born to HIV-infected women. Based on the PCR result on a later sample, the positive predictive value was 97.6% if both replicates were strongly positive (absorbance: 0.8 OD450U), 100% when one of the replicates was strongly positive, and 27% when one or both replicates were weakly positive (but none strongly positive). When both replicates were negative, the negative predictive value was ≥96.2%. Thus, when a single HIV PCR test has a strongly positive result, the infant is very likely to be infected. A positive PCR result after age 1 month was 98.9% accurate in predicting antibody positivity after 15 months.
KW  - antibodies
KW  - blood specimen collection
KW  - diagnosis
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - laboratory methods
KW  - maternal transmission
KW  - polymerase chain reaction
KW  - techniques
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - filter paper
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - laboratory techniques
KW  - mother to child transmission
KW  - PCR
KW  - positive predictive value
KW  - predictive value
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Sexual behavior and injection drug use during pregnancy and vertical transmission of HIV-1.
AU  - Bulterys, M.
AU  - Landesman, S.
AU  - Burns, D. N.
AU  - Rubinstein, A.
AU  - Goedert, J. J.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1997///
VL  - 15
IS  - 1
SP  - 76
EP  - 82
AD  - Bulterys, M.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN/434, Rockville, MD 20852, USA. Correspondence address [Bulterys, M.]: University of New Mexico School of Medicine, 2400 Tucker, NE, FPC Rm 149, Albuquerque, NM 87131-5267, USA.
N1  - Accession Number: 19972006902.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5, 561-27-3. 
N2  - Maternal sexual behaviour and injecting drug use practices were evaluated as possible risk factors for vertical transmission of HIV-1. Data were analysed from the Mothers and Infants Cohort Study, a prospective study in Brooklyn and the Bronx, New York, USA. A total of 207 mother-infant sets were enrolled between 1986 and 1991 and followed for up to 4 years after the enrolment visit during pregnancy. HIV-1 transmission occurred in 49 of 201 mother-infant sets, yielding an overall transmission rate of 24.4% (95% confidence interval (CI) = 18.7% to 31.0%). Increased frequency of vaginal intercourse after the first trimester of pregnancy was positively associated with vertical transmission of HIV-1 (trend P = 0.03). A lifetime history of injecting drug use was not associated with vertical transmission. However, a history of combined cocaine and heroin injection after the first trimester of pregnancy was associated with vertical HIV-1 transmission, particularly among women with CD4+ lymphocyte levels of 20% or higher (risk ratio = 4.0; 95% CI = 2.0 to 8.1). Cocaine and heroin injecting drug use after the first trimester accounted for most of the relation between preterm birth and vertical HIV-1 transmission in this cohort. Maternal coinfection with hepatitis C virus or human T-cell lymphotropic virus types I and II could not explain these observations because coinfection with these viruses had no detectable effect on HIV-1 transmission. These results suggest that maternal sexual behaviour and injection drug use practices during the second and third trimester of pregnancy may modify the risk of vertical HIV-1 transmission.
KW  - cocaine
KW  - drug abuse
KW  - effects
KW  - hepatitis
KW  - hepatitis C
KW  - heroin
KW  - infants
KW  - injecting drug abuse
KW  - injecting drug users
KW  - injection
KW  - maternal transmission
KW  - mixed infections
KW  - mothers
KW  - pregnancy
KW  - risk factors
KW  - sexual behaviour
KW  - sexual intercourse
KW  - T lymphocytes
KW  - transmission
KW  - vagina
KW  - vertical transmission
KW  - women
KW  - New York
KW  - USA
KW  - Deltaretrovirus
KW  - Human immunodeficiency virus 1
KW  - human T-cell lymphotropic virus
KW  - man
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - diacetylmorphine
KW  - diamorphine
KW  - drug use
KW  - gestation
KW  - HTLV-BLV group
KW  - human immunodeficiency virus type 1
KW  - i.v. drug abuse
KW  - i.v. drug abusers
KW  - i.v. drug use
KW  - i.v. drug users
KW  - intravenous drug users
KW  - mother to child transmission
KW  - multiple infections
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - T cells
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Women (UU500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hepatitis C virus diagnostics: technology, clinical applications and impacts.
AU  - Conry-Cantilena, C.
JO  - Trends in Biotechnology
JF  - Trends in Biotechnology
Y1  - 1997///
VL  - 15
IS  - 2
SP  - 71
EP  - 76
SN  - 0167-7799
AD  - Conry-Cantilena, C.: Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982000555.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Public Health
N2  - This review firstly considers the evaluation of hepatitis C virus (HCV) infection by biochemistry and serology, covering biochemical evidence of liver disease and indirect measures of infection, serological assays, first- and second-generation antibody screening assays and third-generation anti-HCV assays. It then addresses viral detection by molecular methods: detection and quantitation of HCV RNA, genotype determination and the future of molecular testing for HCV.
KW  - antibody testing
KW  - applications
KW  - assays
KW  - biochemistry
KW  - genotypes
KW  - hepatitis C
KW  - human diseases
KW  - identification
KW  - liver
KW  - reviews
KW  - serology
KW  - techniques
KW  - technology
KW  - viral diseases
KW  - viral hepatitis
KW  - hepatitis C virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antibody detection
KW  - antibody tests
KW  - viral infections
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Survival after AIDS diagnosis in a cohort of hemophilia patients.
AU  - Gail, M. H.
AU  - Tan W.-Y.
AU  - Pee, D.
AU  - Goedert, J. J.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1997///
VL  - 15
IS  - 5
SP  - 363
EP  - 369
AD  - Gail, M. H.: National Cancer Institute, Executive Plaza North, Room 431, 6130 Executive Boulevard, MSC 7368, Bethesda, MD 20892-7368, USA.
N1  - Accession Number: 19972010745.  Publication Type: Journal Article.  Corporate Author: Multicenter Hemophilia Cohort Study Language: English.  Number of References: 17 ref.
N2  - This study investigated factors affecting survival after the diagnosis of AIDS in a cohort of 1253 patients with haemophilia. The nature of the AIDS-defining condition was found to be as important as age at seroconversion and CD4+ lymphocyte level in predicting survival. A multivariate analysis yielded estimates of median survival for groups defined by age at seroconversion (0 through 15, 16 through 69), CD4+ lymphocyte count (&lt;100 cells/µl versus ≥100 cells/µl), and 10 AIDS-defining disease groups. Estimates of median survival after a single AIDS-defining condition ranged from 3 to 51 months, depending on the diseases. Median survival after a second AIDS-defining condition was about 1.5 to 2.0-fold shorter than after an initial, isolated AIDS-defining condition. HIV-related neurological disease (i.e. AIDS dementia complex or multifocal leukoencephalopathy) was a notable exception. It correlated with the shortest estimates of median survival (3 to 9 months), and this poor prognosis was no worse for patients who had a second AIDS-defining condition. The results of this analysis were consistent in most respects with other published analyses of factors affecting survival. These findings may be useful in the clinical care of persons with AIDS and in estimating the number of persons alive who have had a particular AIDS-defining disease.
KW  - acquired immune deficiency syndrome
KW  - AIDS dementia complex
KW  - clinical aspects
KW  - diagnosis
KW  - disease course
KW  - haemophilia
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphocytes
KW  - patients
KW  - prognosis
KW  - seroconversion
KW  - survival
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - clinical picture
KW  - disease progression
KW  - hemophilia
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Predictors and impact of patients lost to follow-up in a long-term randomized trial of immediate versus deferred antiretroviral treatment.
AU  - Ioannidis, J. P. A.
AU  - Bassett, R.
AU  - Hughes, M. D.
AU  - Volberding, P. A.
AU  - Sacks, H. S.
AU  - Lau, J.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1997///
VL  - 16
IS  - 1
SP  - 22
EP  - 30
AD  - Ioannidis, J. P. A.: HIV Research Branch, Therapeutics Research Program, Divison of AIDS, National Institute of Allergy and Infectious Diseases, Solar Building, Room 2C15, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010825.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 30516-87-1. 
N2  - Predictors for losses to follow-up and the impact of such losses were studied in the AIDS Clinical Trials Group 019 protocol, a long-term randomized trial of immediate versus deferred antiretroviral therapy in asymptomatic HIV-1-infected patients with &gt;500 CD4 cells/µl. The trial was selected because it had the longest follow-up among all antiretroviral trials and the largest percentage of patients whose vital status was unknown at study end. Younger age, a history of parenteral drug use, and nonwhite race were associated with higher rates of loss to follow-up, but race was not an important predictor after adjusting for clinical site. There was large and statistically significant variability in the rates of losses among different clinical sites (P&lt;0.001). Patient retention was significantly better in clinical sites that enrolled many participants, with 25% of enrollees lost to follow-up in sites enrolling &gt;100 patients and 44% in sites enrolling &lt;33 patients each. As a group, patients lost to follow-up after the second year had steeper declines of CD4 cell counts, and a significantly larger proportion had reached a CD4 cell count &lt;300/µl in the year before being lost, compared with patients remaining in the study. Losses to follow-up probably decreased substantially the observed number of primary endpoints, curtailed the power of the trial to demonstrate any difference between immediate and deferred initiation of antiretroviral therapy, and may have introduced large bias in the estimated hazard ratio for the primary endpoint and its statistical significance.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - asymptomatic infections
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - clinical aspects
KW  - clinical trials
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - leukocyte count
KW  - patients
KW  - statistical analysis
KW  - treatment
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - AZT
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - chemotherapy
KW  - clinical picture
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - human immunodeficiency virus infections
KW  - statistical methods
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pradimicins: a novel class of broad-spectrum antifungal compounds.
AU  - Walsh, T. J.
AU  - Giri, N.
JO  - European Journal of Clinical Microbiology & Infectious Diseases
JF  - European Journal of Clinical Microbiology & Infectious Diseases
Y1  - 1997///
VL  - 16
IS  - 1
SP  - 93
EP  - 97
SN  - 0934-9723
AD  - Walsh, T. J.: Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971200513.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Pradimicins are discussed, including structure and structure-function relationship, mechanism of action, in vitro antifungal activity, in vitro antiviral activity, in vivo antifungal activity and toxicity.
KW  - antifungal agents
KW  - antifungal properties
KW  - antiviral properties
KW  - drug therapy
KW  - drug toxicity
KW  - fungicides
KW  - pharmacodynamics
KW  - structure
KW  - structure activity relationships
KW  - therapy
KW  - anti-fungal properties
KW  - anti-viral properties
KW  - chemotherapy
KW  - drug action
KW  - fungicidal properties
KW  - fungistats
KW  - mechanism of drug action
KW  - pradimicins
KW  - therapeutics
KW  - Trends in invasive fungal infections
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasive aspergillosis in human immunodeficiency virus-infected children.
AU  - Shetty, D.
AU  - Giri, N.
AU  - Gonzalez, C. E.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1997///
VL  - 16
IS  - 2
SP  - 216
EP  - 221
SN  - 0891-3668
AD  - Shetty, D.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971202040.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology; Public Health
N2  - The records of 473 HIV-infected children followed in the Pediatric Branch of the National Cancer Institute in the USA during 1987-95 were reviewed for the presence of Aspergillus infection. Seven (1.5%) patients developed invasive aspergillosis during the study period. Causative organisms were A. fumigatus (3 cases), A. glaucus (1) and Aspergillus sp. (3). All patients had low CD4+ counts reflecting severe immunosuppression. Sustained neutropenia (&gt;7 days) or corticosteroid therapy as a predisposing factor for invasive aspergillosis was encountered in only 2 patients (28%). Invasive pulmonary aspergillosis developed in 5 patients and cutaneous aspergillosis in 2. The most common presenting features in patients with pulmonary aspergillosis were fever, cough and dyspnoea. Patients with cutaneous aspergillosis were diagnosed during life and successfully treated with amphotericin B and surgery, whereas diagnosis of pulmonary aspergillosis was made clinically in only 1 patient. It is concluded that aspergillosis is an uncommon but highly lethal opportunistic infection in HIV-infected children.
KW  - acquired immune deficiency syndrome
KW  - amphotericin B
KW  - aspergillosis
KW  - children
KW  - clinical aspects
KW  - epidemiology
KW  - hiv infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - North America
KW  - USA
KW  - Aspergillus
KW  - Aspergillus fumigatus
KW  - Eurotium herbariorum
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Aspergillus
KW  - Eurotium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - Aspergillus glaucus
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Cytomegalovirus infection in children with human immunodeficiency virus infection.
AU  - Kitchen, B. J.
AU  - Engler, H. D.
AU  - Gill, V. J.
AU  - Marshall, D.
AU  - Steinberg, S. M.
AU  - Pizzo, P. A.
AU  - Mueller, B. U.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1997///
VL  - 16
IS  - 4
SP  - 358
EP  - 363
SN  - 0891-3668
AD  - Kitchen, B. J.: Pediatric Branch, National Cancer Institute, 10 Center Drive, Bethesda, MD, USA.
N1  - Accession Number: 19972005456.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref.
N2  - To determine the prevalence of positive cytomegalovirus (CMV) cultures in paediatric patients with HIV infection, the case records of 273 HIV-infected children referred to the Pediatric Branch of the National Cancer Institute, USA, for whom CMV cultures were performed during January 1991-October 1994, were reviewed. Of this group, 189 patients (69%) had negative CMV cultures and 84 (31%) had positive cultures. The prevalence of CMV-related disease was 9% for the entire group, including 4 (2.1%) patients with negative CMV cultures. Among the 84 patients with positive CMV cultures, 21 (25%) had evidence of CMV disease. Patients with positive CMV cultures had a statistically significant decrease in survival in the presence of severe immunocompromise defined as an age-corrected CD4+ count of &lt;21%. Of 35 postmortem examinations performed, 9 (26%) demonstrated evidence of CMV disease, including 7 patients with disseminated CMV disease. It is concluded that although CMV disease appears to be less frequent in children than adults, CMV infection still contributes significantly to morbidity and mortality in this population, especially when combined with severe immunosuppression.
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - children
KW  - clinical aspects
KW  - disseminated infections
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infection
KW  - leukocyte count
KW  - mortality
KW  - opportunistic infections
KW  - patients
KW  - survival
KW  - viral diseases
KW  - USA
KW  - Cytomegalovirus
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - clinical picture
KW  - death rate
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T4 lymphocytes
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fatal Nocardia pulmonary infection in a child with acquired immunodeficiency syndrome and lymphoid interstitial pneumonitis.
AU  - Zwerski, S.
AU  - Witebsky, F. G.
AU  - Conville, P. S.
AU  - Gill, V. J.
AU  - Freifeld, A. G.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1997///
VL  - 16
IS  - 11
SP  - 1088
EP  - 1089
SN  - 0891-3668
AD  - Zwerski, S.: Pediatric Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981200442.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 9-year-old boy from Maryland, USA, with vertically-acquired HIV infection and a 7-year history of progressive bilateral interstitial infiltrates presumed to be due to lymphoid interstitial pneumonitis (LIP), who presented in 1996 with exacerbation of LIP. Histological examination of bronchoalveolar lavage samples revealed long branching organisms consistent with Nocardia and cultures grew Nocardia sp. Chest computed tomography demonstrated consolidation and multiple cavities with possible bronchiectasis in the left lower lobe. Despite administration of trimethoprim sulfamethoxazole and antibiotics the patient's condition deteriorated, with increasing pulmonary insufficiency and he died of cardiac failure 3 months later.
KW  - acquired immune deficiency syndrome
KW  - boys
KW  - case reports
KW  - children
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - nocardiosis
KW  - opportunistic infections
KW  - pneumonitis
KW  - Maryland
KW  - USA
KW  - man
KW  - Nocardia
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nocardiaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - bacterium
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - sulfamethoxazole trimethoprim
KW  - trimethoprim sulfamethoxazole
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration.
AU  - Wei ShuiQing
AU  - Mizuuchi, K.
AU  - Craigie, R.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997///
VL  - 16
IS  - 24
SP  - 7511
EP  - 7520
SN  - 0261-4189
AD  - Wei ShuiQing: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982002792.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 9007-49-2. 
N2  - The nucleoprotein organization of Moloney murine leukaemia virus (MLV) pre-integration complexes was probed using a novel footprinting technique that utilizes a simplified in vitro phage Mu transposition system. It was found that several hundred base pairs at each end of the viral DNA are organized in a large nucleoprotein complex, which were termed the intasome. This structure is not formed when pre-integration complexes are made by infecting cells with integrase-minus virus, demonstrating a requirement for integrase. In contrast, footprinting of internal regions of the viral DNA did not reveal sigificant differences between pre-integration complexes with and without integrase. Treatment with high salt disrupts the intasome in parallel with loss of intermolecular integration activity. It was shown that a cellular factor is required for reconstitution of the intasome. Finally, it was demonstrated that DNA-protein interactions involving extensive regions at the ends of the viral DNA are functionally important for retroviral DNA integration activity. Current in vitro integration systems utilizing purified integrase lack the full fidelity of the in vivo reaction. These results indicate that both host factors and long viral DNA substrates may be required to reconstitute an in vitro system with all the hallmarks of DNA integration in vivo.
KW  - DNA
KW  - hosts
KW  - human diseases
KW  - in vitro
KW  - integration
KW  - interactions
KW  - leukaemia
KW  - nucleoproteins
KW  - replication
KW  - structure
KW  - substrates
KW  - systems
KW  - transposition
KW  - treatment
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - Murine leukemia virus
KW  - Retroviridae
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Gammaretrovirus
KW  - blood cancer
KW  - deoxyribonucleic acid
KW  - gene transposition
KW  - human immunodeficiency virus type 1
KW  - leucaemia
KW  - leukemia
KW  - murine leukaemia virus
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - An approach to estimating exposure-specific rates of breast cancer from a two-stage case-control study within a cohort.
AU  - Benichou, J.
AU  - Byrne, C.
AU  - Gail, M.
JO  - Statistics in Medicine
JF  - Statistics in Medicine
Y1  - 1997///
VL  - 16
IS  - 1/3
SP  - 133
EP  - 151
SN  - 0277-6715
AD  - Benichou, J.: National Cancer Institute, Biostatistics Branch, 6130 Executive Blvd, EPN/403, MSC 7368, Bethesda, MD 20892-7368, USA.
N1  - Accession Number: 19972005745.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Public Health
N2  - The Breast Cancer Detection and Demonstration Project (BCDDP) included a cohort of &gt;280 000 women followed for incidence of breast cancer for 5 years. These women volunteered to enrol in 29 centres in the USA between 1973 and 1980. An initial case-control sample (n = 3000) was drawn and standard risk factors obtained. In order to study the effect of mammographical features on breast cancer risk, a nested subsample of cases and controls was drawn. These data can be viewed as 2-stage case-control data within a cohort, or as cohort data with 2 nested levels of missingness, since basic characteristics like age were measured on all members of the cohort, standard risk factors were elicited only in the initial case-control sample, and mammographical features were assessed only in the nested subsample of cases and controls. A Poisson pseudo-likelihood approach to estimating age- and exposure-specific breast cancer incidence rates based on the 3 types of variables is presented. This approach takes into account the nested missingness as well as 2 other types of missingness, namely, that for basic variables and standard risk factors, some levels were omitted by design in the nested subsample of case and controls or were empty because of the sparsity of the data in that subsample. Estimates of standard errors are obtained from a parametric bootstrap. The approach is concluded to be efficient when applied to the BCDDP data and to be flexible for modelling breast cancer rates and taking the special missingness features of these data into account.
KW  - breast
KW  - breast cancer
KW  - epidemiology
KW  - estimation
KW  - neoplasms
KW  - risk factors
KW  - volunteers
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary change as a strategy for preventing cancer.
AU  - Schatzkin, A.
JO  - Cancer and Metastasis Reviews
JF  - Cancer and Metastasis Reviews
Y1  - 1997///
VL  - 16
IS  - 3/4
SP  - 377
EP  - 392
SN  - 0167-7659
AD  - Schatzkin, A.: National Cancer Institute, Rockville Pike, Bethesda, Maryland, USA.
N1  - Accession Number: 19981407172.  Publication Type: Journal Article.  Language: English.  Number of References: 93 ref. Subject Subsets: Human Nutrition
KW  - aetiology
KW  - breast
KW  - colon
KW  - diet
KW  - mortality
KW  - neoplasms
KW  - nutrition
KW  - prevention
KW  - prostate
KW  - rectum
KW  - breasts
KW  - cancers
KW  - causal agents
KW  - death rate
KW  - etiology
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmacometric analysis of the effect of furosemide on suramin pharmacokinetics.
AU  - Piscitelli, S. C.
AU  - Forrest, A.
AU  - Lush, R. M.
AU  - Ryan, N.
AU  - Whitfield, L. R.
AU  - Figg, W. D.
JO  - Pharmacotherapy
JF  - Pharmacotherapy
Y1  - 1997///
VL  - 17
IS  - 3
SP  - 431
EP  - 437
SN  - 0277-0008
AD  - Piscitelli, S. C.: Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19970806209.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 54-31-9, 145-63-1.  Subject Subsets: Protozoology
N2  - The effects of furosemide on the pharmacokinetics of suramin were investigated in a group of 27 patients who were receiving the drug for cancer therapy. The patients received suramin by continuous or intermittent infusion with and without concomitant furosemide. Optimum suramin regimens were achieved by adaptive feedback control, and pharmacokinetic data were collected both in the presence and absence of furosemide. Suramin concentrations were determined by HLPC and were fit to a 3-compartment linear model with 6 coefficients and 2 rate inputs, which allowed furosemide to affect suramin pharmacokinetics. Individual and population parameter estimates were determined using the interactive 2-stage approach. Concomitant furosemide was associated with a median decrease in total body clearance of suramin by 36% (range 0-63%, p&lt;0.001). No other parameter was significantly altered and there was no trend for change in any pharmacokinetic value with time. Suramin plasma concentrations were simulated with and without prolonged furosemide therapy in 26 patients for 12 weeks. The average suramin concentration increased by &gt;33% in 12 patients; 2 patients had a &gt;67% increase in this extreme case model. It was concluded that co-administration of furosemide with suramin can cause an increase in suramin concentrations; however, due to the long half-life of suramin, its rate of accumulation is very slow.
KW  - antiprotozoal agents
KW  - blood plasma
KW  - drug combinations
KW  - furosemide
KW  - parasites
KW  - pharmacokinetics
KW  - suramin
KW  - trypanocides
KW  - man
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - plasma (blood)
KW  - trypanocidal drugs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Physical and functional interaction between the human T-cell lymphotropic virus type 1 tax protein and the CCAAT binding protein NF-Y.
AU  - PiseMasison, C. A.
AU  - Dittmer, J.
AU  - Clemens, K. E.
AU  - Brady, J. N.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1997///
VL  - 17
IS  - 3
SP  - 1236
EP  - 1243
SN  - 0270-7306
AD  - PiseMasison, C. A.: Virus Tumor Biology Section, Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA.
N1  - Accession Number: 19972007918.  Publication Type: Journal Article.  Language: English.  Number of References: 93 ref. Registry Number: 9007-49-2, 70-18-8. 
N2  - Tax1, a potent activator of human T-cell lymphotropic virus type 1 (HTLV-1) transcription, has been shown to modulate expression of many cellular genes. Tax1 does not bind DNA directly but regulates transcription through protein-protein interactions with sequence-specific transcription factors. Using the yeast two-hybrid system to screen for proteins which interact with Tax1, we isolated the B subunit of the CCAAT binding protein NF-Y from a HeLa cDNA library. The interaction of Tax1 with NF-YB was specific in that NF-YB did not interact with a variety of other transcription factors, including human immunodeficiency virus Tat, human papillomavirus E6, and Bicoid, or with the M7 (amino acids 29CP-AS) Tax1 mutant. However, NF-YB did interact with the C-terminal Tax1 mutants M22 (130TL-AS) and M47 (319LL-RS). We also show that in vitrotranslated NF-YB specifically bound to a glutathione S-transferase-Tax1 fusion protein. Further, Tax1 coimmunoprecipitated with NF-Y from nuclear extracts of HTLV-1-transformed cells, providing evidence for in vivo interaction of Tax1 and NF-YB. We further demonstrate that Tax1 specifically activated the NF-Y-responsive DQΒ promoter, as well as a minimal promoter which contains only the Y-box element. In addition, mutation of the Y-box element alone abrogated Tax1-mediated activation. Taken together, these data indicate that Tax1 interacts with NF-Y through the B subunit and that this interaction results in activation of the major histocompatibility complex class II promoter. Through activation of this and other NF-Y driven promoters, the Tax1-NF-Y interaction may play a critical role in causing cellular transformation and HTLV-1 pathogenesis.
KW  - acquired immune deficiency syndrome
KW  - bacterial toxins
KW  - complementary DNA
KW  - DNA
KW  - extracts
KW  - glutathione
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - major histocompatibility complex
KW  - mutants
KW  - mutations
KW  - promoters
KW  - proteins
KW  - T lymphocytes
KW  - transcription
KW  - yeasts
KW  - Deltaretrovirus
KW  - human papillomaviruses
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - fungi
KW  - eukaryotes
KW  - Papillomaviridae
KW  - dsDNA Viruses
KW  - DNA Viruses
KW  - Deltaretrovirus
KW  - Human T-cell lymphotropic virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Papillomavirus
KW  - AIDS
KW  - B subunit
KW  - cDNA
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - fungus
KW  - histocompatibility complex
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human papillomavirus
KW  - Papovaviridae
KW  - promoter region
KW  - promoter sequences
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary restriction mitigates ozone-induced lung inflammation in rats: a role for endogenous antioxidants.
AU  - Kari, F.
AU  - Hatch, G.
AU  - Slade, R.
AU  - Crissman, K.
AU  - Simeonova, P. P.
AU  - Luster, M.
JO  - American Journal of Respiratory Cell and Molecular Biology
JF  - American Journal of Respiratory Cell and Molecular Biology
Y1  - 1997///
VL  - 17
IS  - 6
SP  - 740
EP  - 747
SN  - 1044-1549
AD  - Kari, F.: Environmental Immunology and Neurobiology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 19981415442.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 59-02-9, 70-18-8, 10028-15-6.  Subject Subsets: Human Nutrition
N2  - Male F344 rats were fed NIH-31 diet ad libitum (n=10) or restricted at 75% of ad libitum intake (n=10). After 3 weeks of dietary adaptation, rats were exposed by inhalation to 2.0 mg/kg ozone (O3) for 2 h or chamber air and evaluated for cellular and biochemical indices of pulmonary toxicity. Compared with air controls, bronchoalveolar lavage fluid (BALF) from O3 exposed ad libitum fed rats contained increased protein (145 vs. 380 µg/ml), polymorphonuclear cell (PMN) infiltration (0 vs. 11%) and fibronectin (45 versus 607 U/ml). Diet restriction abrogated these indicators of pulmonary inflammation induced by ozone. Binding of 18O3 to BALF protein and cells was significantly decreased in diet restricted rats while BALF ascorbate and glutathione levels, but not α-tocopherol or urate, were increased compared with ad libitum fed rats. It is concluded that dietary restriction affords protection against O3-induced oxidant toxicity. Protection is mediated partially by increases in ascorbate in the fluid bathing the lung surface, thereby providing an antioxidant sink which minimizes the ability of O3 to reach biological targets.
KW  - alpha-tocopherol
KW  - antioxidants
KW  - fibronectins
KW  - food restriction
KW  - glutathione
KW  - inflammation
KW  - lungs
KW  - ozone
KW  - restricted feeding
KW  - toxicity
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Emerging parasitic infections.
AU  - James, S. L.
JO  - FEMS Immunology and Medical Microbiology
JF  - FEMS Immunology and Medical Microbiology
Y1  - 1997///
VL  - 18
IS  - 4
SP  - 313
EP  - 317
SN  - 0928-8244
AD  - James, S. L.: Division of Microbiology and Infectious Diseases, NIAID, National Institutes of Health, Solar Building, Room 3A10, 6003 Executive Boulevard, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980806212.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Helminthology
N2  - This review of emerging and re-emerging parasitic diseases briefly discusses Cryptosporidium, Cyclospora, Enterocytozoon bieneusi, Septata intestinalis, Isospora belli, Toxoplasma gondii, Acanthamoeba, Babesia microti, Baylisascaris procyonis, Leishmania, Echinococcus multilocularis, Trypanosoma cruzi and Taenia solium, particularly with regard to the USA, and AIDS-related immunosuppression.
KW  - emerging infectious diseases
KW  - helminths
KW  - human diseases
KW  - immunocompromised hosts
KW  - parasites
KW  - parasitoses
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - emerging diseases
KW  - emerging infections
KW  - parasitic diseases
KW  - parasitic infestations
KW  - parasitic worms
KW  - parasitosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806212&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The relationship between study design, results, and reporting of randomized clinical trials of HIV infection.
AU  - Ioannidis, J. P. A.
AU  - Cappelleri, J. C.
AU  - Sacks, H. S.
AU  - Lau, J.
JO  - Controlled Clinical Trials
JF  - Controlled Clinical Trials
Y1  - 1997///
VL  - 18
IS  - 5
SP  - 431
EP  - 444
SN  - 0197-2456
AD  - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Building Room 2C15, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010702.  Publication Type: Journal Article; Annual report; Journal article.  Language: English.  Number of References: 25 ref. Registry Number: 30516-87-1. 
N2  - The purpose of this study was to examine whether the study design of randomized clinical trials for medications against HIV may affect the results and whether the outcomes of these trials affect reporting and publication. A database of 71 published randomized HIV-related drug efficacy trials was used and the following study design factors were considered: endpoint definition and method of analysis, masked design, sample size, and duration of follow-up. The study revealed that design factors may have an impact on the magnitude and significance of the treatment effect in HIV-related trials. Bias in reporting can further affect the information that these studies provide. Compared with trials published in specialized journals, trials published in journals of wide readership were larger (P = 0.001) and 4.4 times more likely to report "positive" results (P = 0.01). Several samples of trials with "negative" results that have remained unpublished for a long time were identified.
KW  - clinical aspects
KW  - clinical trials
KW  - databases
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - information
KW  - publications
KW  - relationships
KW  - research
KW  - survival
KW  - treatment
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - clinical picture
KW  - data banks
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010702&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The human health effects of DDT (dichlorodiphenyl-trichloroethane) and PCBs (polychlorinated biphenyls) and an overview of organochlorines in public health.
AU  - Longnecker, M. P.
AU  - Rogan, W. J.
AU  - Lucier, G.
JO  - Annual Review of Public Health
JF  - Annual Review of Public Health
Y1  - 1997///
VL  - 18
SP  - 211
EP  - 244
SN  - 0163-7525
AD  - Longnecker, M. P.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
N1  - Accession Number: 19971109335.  Publication Type: Journal Article.  Language: English.  Number of References: 7 pp. of ref. Registry Number: 50-29-3.  Subject Subsets: Agricultural Entomology; Medical & Veterinary Entomology
N2  - A review of data cited in the 1991-95 Medline database and elsewhere showed that high-level exposure to selected organochlorines (including DDT) in man appears to cause abnormal functioning of the liver, skin (chloracne) and nervous system. Of more general interest, however, was evidence suggesting insidious effects of background exposure. Of particular concern was the finding of neonatal hypotonia or hyporeflexia in relation to exposure to polychlorinated biphenyls (PCBs). The epidemiological data reviewed, considered in isolation, provided no convincing evidence that organochlorines cause a large excess number of cancers. A recent risk assessment that considered animal data, however, gave a cancer risk estimate for background exposure to dioxin and dioxin-like compounds (e.g. some PCBs) with an upper limit in the range of 10-4 per year.
KW  - agricultural entomology
KW  - DDT
KW  - insecticides
KW  - liver
KW  - neoplasms
KW  - nervous system
KW  - nontarget effects
KW  - organochlorine pesticides
KW  - pesticides
KW  - polychlorinated biphenyls
KW  - reviews
KW  - skin
KW  - toxicity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - dermis
KW  - dicophane
KW  - organic chlorine pesticides
KW  - PCBs
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971109335&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunologic aspects of osteoporosis.
AU  - Ershler, W. B.
AU  - Harman, S. M.
AU  - Keller, E. T.
JO  - Developmental and Comparative Immunology
JF  - Developmental and Comparative Immunology
Y1  - 1997///
VL  - 21
IS  - 6
SP  - 487
EP  - 487
SN  - 0145-305X
AD  - Ershler, W. B.: Gerontologic Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
N1  - Accession Number: 19981407151.  Publication Type: Journal Article.  Language: English.  Number of References: 127 ref. Subject Subsets: Human Nutrition
N2  - Following a brief introduction, the risk factors of osteoporosis and as a major health concern to the geriatric population are reviewed. The role of interleukin-6 (IL-6) in the pathogenesis of osteoporosis is discussed including, the increase with age of IL-6 and receptor levels, the relationship with oestrogen and androgens, the enhancement of osteoclastogenesis and bone remodelling. Topics also discussed include: an age associated decrease of osteoblast numbers associated with age-related osteoporosis; changes in osteoclast activity as a possible contributor to age-associated osteoporosis; hormones, aging and osteoporosis; and immunsenescence, cytokines and osteoporosis. It is concluded that there is substantial support for the hypothesis that certain pro-inflammatory cytokines, such as IL-1 and IL-6, are important in the normal bone remodelling process and in the pathogenesis of post-menopausal osteoporosis.
KW  - aging
KW  - bones
KW  - immunology
KW  - interleukins
KW  - osteoporosis
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407151&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A new 85 kDa, breast tumour associated antigen-a potential diagnostic and prognostic agent.
AU  - Utpala Chattopadhyay
AU  - Saumitra Pal
JO  - Journal of Biosciences
JF  - Journal of Biosciences
Y1  - 1997///
VL  - 22
IS  - 1
SP  - 69
EP  - 75
SN  - 0250-5991
AD  - Utpala Chattopadhyay: Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Calcutta 700 026, India.
N1  - Accession Number: 19972007433.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Tropical Diseases
N2  - A breast tumour associated antigen (BTAA) was isolated from the breast tumour tissues of untreated female cancer patients in Calcutta, India. The BTAA purified by DEAE discontinuous column chromatography followed by size exclusion HPLC was an 85 kDa glycoprotein. A high level of circulating antibodies against this antigen was observed, using ELISA, in 30/30 untreated female breast cancer patients. The BTAA was not immunologically related to murine mammary tumour virus (MuMTV) antigens but strongly resembled an 83 kDa glycoprotein tumour associated antigen, purified from MuMTV induced mouse mammary tumour. In patients after surgical removal of the breast tumour (20 patients), the circulating antibodies to the BTAA decreased gradually, but reappeared in the patients with secondary metastasis. In 10 healthy age matched women and in 5 female patients with carcinoma of tissues other than breast, no significant titre of the BTAA antibodies was observed.
KW  - antibodies
KW  - antigens
KW  - breast
KW  - breast cancer
KW  - carcinoma
KW  - characterization
KW  - diagnosis
KW  - ELISA
KW  - human diseases
KW  - immunological techniques
KW  - neoplasms
KW  - purification
KW  - Asia
KW  - India
KW  - West Bengal
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - antigenicity
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - enzyme linked immunosorbent assay
KW  - immunogens
KW  - serological techniques
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007433&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Results of a community-based low-literacy nutrition education program.
AU  - Hartman, T. J.
AU  - McCarthy, P. R.
AU  - Park, R. J.
AU  - Schuster, E.
AU  - Kushi, L. H.
JO  - Journal of Community Health
JF  - Journal of Community Health
Y1  - 1997///
VL  - 22
IS  - 5
SP  - 325
EP  - 341
SN  - 0094-5145
AD  - Hartman, T. J.: National Cancer Institute, Executive Plaza North, Suite 211, 6130 Executive Boulevard MSC 7326, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19981407091.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
N2  - A nutrition intervention focused on low-fat eating pattern changes was conducted among low-literacy participants in a Twin Cities Metropolitan area Expanded Food and Nutrition Education Programme (EFNEP) in the USA. A total of 134 EFNEP participants who participated in the intervention were compared to 70 comparison participants who received EFNEP nutrition education materials. Associations between changes in outcome variables specific to the intervention were evaluated using mixed-model regression analyses. The principal effects seen for this programme were related to changes in eating pattern scales. More modest effects were seen in scales related to attitudes of low-fat eating and although changes in dietary fat intake as measured by 24-h dietary interviews suggested a positive intervention effect, this did not approach significance.
KW  - fats
KW  - intake
KW  - nutrition education
KW  - nutrition programmes
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - feeding programmes
KW  - feeding programs
KW  - food programs
KW  - nutrition programs
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407091&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Disseminated zygomycosis in a neutropenic patient: successful treatment with amphotericin B lipid complex and granulocyte colony-stimulating factor.
AU  - Gonzalez, C. E.
AU  - Couriel, D. R.
AU  - Walsh, T. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1997///
VL  - 24
IS  - 2
SP  - 192
EP  - 196
SN  - 1058-4838
AD  - Gonzalez, C. E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971200837.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 59-year-old man from Maryland, USA, who developed persistent fever during a period of neutropenia in April 1993 following treatment for aplastic anaemia. Computed tomography (CT) of the chest revealed a mass in the right upper lobe and needle aspiration was performed. Cultures of the aspirate grew Rhizomucor pusillus and the lesion was resected. Treatment with amphotericin B (1.5 mg/kg daily) and granulocyte colony-stimulating factor (G-CSF) was started. Due to deteriorating renal function, therapy was later changed to amphotericin B lipid complex (ABLC; 4 mg/kg daily) and continued for 1 month. In August 1993 the patient was readmitted with a 3-week history of fever and right upper quadrant pain. Abdominal ultrasonography revealed bilateral, hypoechoic, solid renal masses and fine needle aspiration of these yielded necrotic debris and hyphal elements. R. pusillus was cultured from the aspirate and from urine samples. Symptoms gradually resolved after treatment with intravenous ABLC (4 mg/kg daily) and G-CSF.
KW  - amphotericin B
KW  - application methods
KW  - case reports
KW  - colony stimulating factor
KW  - cytokines
KW  - generalized infections
KW  - hosts
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunology
KW  - immunotherapy
KW  - infections
KW  - kidneys
KW  - lipids
KW  - men
KW  - neutropenia
KW  - opportunistic infections
KW  - predisposition
KW  - therapy
KW  - treatment
KW  - zygomycosis
KW  - Maryland
KW  - USA
KW  - man
KW  - Mucoraceae
KW  - Rhizomucor pusillus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mucorales
KW  - Mucoromycotina
KW  - Zygomycota
KW  - fungi
KW  - Rhizomucor
KW  - Mucoraceae
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fungus
KW  - lipins
KW  - phycomycosis
KW  - therapeutics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200837&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vaginal colonization or infection with Candida albicans in human immunodeficiency virus-infected women during pregnancy and during the postpartum period.
AU  - Burns, D. N.
AU  - Tuomala, R.
AU  - Chang BeiHung
AU  - Hershow, R.
AU  - Minkoff, H.
AU  - Rodriguez, E.
AU  - Zorrilla, C.
AU  - Hammill, H.
AU  - Regan, J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1997///
VL  - 24
IS  - 2
SP  - 201
EP  - 210
SN  - 1058-4838
AD  - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19972003063.  Publication Type: Journal Article.  Corporate Author: Women and Infants Transmission Study Group. Language: English.  Subject Subsets: Medical & Veterinary Mycology
N2  - This study evaluated the relationship between immunological status and vaginal colonization or infection with Candida albicans for 605 women from the USA, who were enrolled in a multicentre, prospective cohort study of mother-to-infant transmission of HIV-1. A low CD4+ level (&lt;14% vs. ≥14%, which corresponds to an absolute count of approx. 200 × 106/l) was associated with a 2- to 5-fold increased likelihood of vaginal colonization (odds ratio (OR), 2.28; 95% CI 1.01-5.19) and vaginal candidosis (OR, 3.08; 95% CI, 1.21-7.71) during pregnancy and during the postpartum period (OR, 2.98; 95% CI, 1.51-5.88 and OR, 5.45; 95% CI, 1.73-16.6, respectively). These associations persisted in multivariate logistic regression analyses. No associations with CD8+ lymphocyte levels or CD8+CD38+ or other lymphocyte subset levels were found after adjustment for CD4+ cell count and other covariates. However, postpartum (but not antepartum) antibiotic use and pregnancy were also associated with vaginal colonization and candidosis (P≤0.001 for each). Vaginal candidosis was not associated with an increased risk of mother-to-infant transmission of HIV-1; however, a related more inclusive variable, clinical vaginitis, or vaginosis of any aetiology at the last antepartum visit, was associated with mother-to-infant transmission (OR, 1.92; 95% CI, 1.07-3.43). These findings emphasize the complex, multifactorial nature of vaginal candidosis and highlight the need for safe and effective treatment and prevention strategies for women with advanced HIV infection.
KW  - acquired immune deficiency syndrome
KW  - candidosis
KW  - colonization
KW  - HIV infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - immunological deficiency
KW  - immunology
KW  - infection
KW  - infections
KW  - maternal transmission
KW  - mothers
KW  - opportunistic infections
KW  - postpartum period
KW  - predisposition
KW  - pregnancy
KW  - risk factors
KW  - transmission
KW  - vagina
KW  - women
KW  - USA
KW  - candida albicans
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - candidiasis
KW  - fungus
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Hyphomycetes
KW  - immune deficiency
KW  - immunodeficiency
KW  - mother to child transmission
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003063&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene.
AU  - Tilly, K.
AU  - Casjens, S.
AU  - Stevenson, B.
AU  - Bono, J. L.
AU  - Samuels, D. S.
AU  - Hogan, D.
AU  - Rosa, P.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997///
VL  - 25
IS  - 2
SP  - 361
EP  - 373
SN  - 0950-382X
AD  - Tilly, K.: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980501931.  Publication Type: Journal Article.  Language: English.  Number of References: 78 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The 26-28 kb circular plasmid of B. burgdorferi s.l. (cp26) is ubiquitous among bacteria of this group and contains loci implicated in the mouse-tick transmission cycle. Restriction mapping and Southern hybridization indicated that the structure of cp26 is conserved among isolates from different origins and culture passage histories. The cp26 ospC gene encodes an outer surface protein whose synthesis within infected ticks increases when the ticks feed, and whose synthesis in culture increases after a temperature upshift. Previous studies of ospC coding sequences showed them to have stretches of sequence apparently derived from the ospC genes of distantly related isolates by homologous recombination after DNA transfer. Conservation was found of the promoter regions of the ospC and guaA genes, which are divergently transcribed. The increase in OspC protein after a temperature upshift was shown to parallel increases in mRNA levels, as expected if regulatory regions adjoin the conserved sequences in the promoter regions. Finally, directed insertion was used to inactivate the ospC gene of a non-infectious isolate. This first example of directed gene inactivation in B. burgdorferi shows that the OspC protein is not required for stable maintenance of cp26 or growth in culture.
KW  - genes
KW  - inactivation
KW  - molecular genetics
KW  - nucleotide sequences
KW  - plasmids
KW  - temperature
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - ospA
KW  - outer surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501931&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HTLV-I Tax self-association in optimal trans-activation function.
AU  - Jin DongYan
AU  - Jeang KuanTeh
JO  - Nucleic Acids Research
JF  - Nucleic Acids Research
Y1  - 1997///
VL  - 25
IS  - 2
SP  - 379
EP  - 387
SN  - 0305-1048
AD  - Jin DongYan: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972004876.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref.
N2  - The one hybrid and two hybrid genetic approaches in yeast were used to investigate the region(s) within HTLV-I Tax necessary for self-association. Dimer formation was also confirmed biochemically by using electrophoretic mobility shift (EMSA) and supershift assays. 22 Tax point mutants were utilized to map relevant residues. Genetic results from this series of mutants revealed that a necessary region for dimerization is contained within a previously characterized zinc finger domain. Two loss-of-function Tax mutants, each poorly active when assayed individually were found to have complementing activity when co-expressed together. This genetic complementation suggests a mechanism for trans-activation resulting from simultaneous but non-identical contact with a responsive target by each of 2 Tax monomers in a dimer.
KW  - genes
KW  - genetics
KW  - htlv-i infections
KW  - human diseases
KW  - mutants
KW  - tax protein
KW  - transcription
KW  - viral regulatory proteins
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type i
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004876&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Decay rates of anti-HIV dideoxynucleotides in tissue culture systems: a simple correction for the effect of cell replication.
AU  - Ahluwaia, G. S.
AU  - Dedrick, R. L.
AU  - Driscoll, J. S.
AU  - Morrison, P. F.
AU  - Gao WenYi
AU  - Johns, D. G.
JO  - Drug Metabolism and Disposition
JF  - Drug Metabolism and Disposition
Y1  - 1997///
VL  - 25
IS  - 7
SP  - 893
EP  - 896
SN  - 0090-9556
AD  - Ahluwaia, G. S.: Correspondence address [Burnes, D. G.]: Building 37, Rm 5B22, Laboratory of Medicinal Chemstry, Division of Basic Sciences, National Cancer Institute/NIH, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972007176.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref.
N2  - Measurement of intracellular drug levels in cell culture systems can be of predictive value in establishing rational clinical dosage schedules. Such in vitro measurements carried out with anti-HIV agents of the 2′,3′-dideoxynucleoside (ddN) class have shown that many of the pharmacologically active ddNTP metabolites of these agents have relatively long intracellular half-lives and little or no host-cell cytotoxicity. As a consequence, replication of drug-exposed cells continues at an unperturbed rate so that a systematic dilution error occurs in the measurement of ddNTP decay half-times. The aim of this study is to present a simple general formulation for the correction of measured t1/2-values for ddNTPs and for other agents with similar intracellular pharmacokinetic properties. Two factors of practical interest emerge: first, the error is greater for agents with slow intracellular clearance rates than for agents with rapid rates; and second, for cell lines with long doubling times, the measured t1/2-values approach more closely the true t1/2-values, until with the extreme case (quiescent or "G0" cells), the observed and true decay times are identical. The greatest dilution errors are seen with adenosine-based agents such as ddATP and 2′-F-ddATP, while the smallest errors are seen with rapidly cleared agents of the dideoxythymidine class.
KW  - analogues
KW  - antiviral agents
KW  - cell lines
KW  - clinical aspects
KW  - decay
KW  - drug therapy
KW  - effects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - mathematical models
KW  - measurement
KW  - metabolism
KW  - metabolites
KW  - nucleoside analogues
KW  - nucleosides
KW  - pharmacokinetics
KW  - replication
KW  - tissue culture
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - metrology
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007176&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasion and cytopathic killing of human lymphocytes by spirochetes causing Lyme disease.
AU  - Dorward, D. W.
AU  - Fischer, E. R.
AU  - Brooks, D. M.
A2  - Bosler, E.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1997///
VL  - 25
IS  - Suppl. 1
SP  - S2
EP  - S8
SN  - 1058-4838
AD  - Dorward, D. W.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980501763.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - To examine the nature and consequences of interactions between Lyme disease spirochaetes and immune effector cells, Borrelia burgdorferi s.l. was coincubated with primary and cultured human leukocytes. It was found that B. burgdorferi actively attaches to, invades, and kills human B and T lymphocytes. Significant killing began within 1 h of mixing. Cytopathic effects varied with respect to host cell lineage and the species, viability, and degree of attenuation of the spirochaetes. Both spirochaetal virulence and lymphocytic susceptibility could be phenotypically selected, thus indicating that both bacterial and host cell factors contribute to such interactions. These results suggest that invasion and lysis of lymphocytes may constitute previously unrecognized factors in Lyme disease and bacterial pathogenesis.
KW  - cells
KW  - cytopathogenicity
KW  - invasion
KW  - leukocytes
KW  - Lyme disease
KW  - lymphocytes
KW  - pathogenicity
KW  - Borrelia burgdorferi
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Annual international conference on Lyme borreliosis and other tick-borne diseases
KW  - bacterium
KW  - Basic and clinical approaches to Lyme disease: a Lyme Disease Foundation symposium
KW  - leucocytes
KW  - lyme borreliosis
KW  - white blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501763&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The antimicrobial agent melittin exhibits powerful in vitro inhibitory effects on the Lyme disease spirochete.
AU  - Lubke, L. L.
AU  - Garon, C. F.
A2  - Bosler, E.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1997///
VL  - 25
IS  - Suppl. 1
SP  - S48
EP  - S51
SN  - 1058-4838
AD  - Lubke, L. L.: Bacterial Pathogenesis Section, Rocky Mountain Laboratories Microscopy Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980501772.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 15 ref. Registry Number: 20449-79-0.  Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia burgdorferi has demonstrated a capacity to resist the in vitro effects of powerful eukaryotic and prokaryotic metabolic inhibitors. However, treatment of laboratory cultures on Barbour-Stoenner-Kelly medium with melittin showed immediate and profound inhibitory effects when they were monitored by dark-field microscopy, field emission scanning electron microscopy, and optical density measurements. Furthermore, at melittin concentrations as low as 100 µg/ml, virtually all spirochaete motility ceased within seconds of inhibitor addition. Ultrastructural examination of these spirochaetes by scanning electron microscopy revealed obvious alterations in the surface envelope of the spirochaetes.
KW  - antibacterial properties
KW  - hive products
KW  - Lyme disease
KW  - melittin
KW  - scanning electron microscopy
KW  - toxicity
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Annual international conference on Lyme borreliosis and other tick-borne diseases
KW  - bactericidal properties
KW  - bacterium
KW  - Basic and clinical approaches to Lyme disease: a Lyme Disease Foundation symposium
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Apiculture (LL010) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501772&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition.
AU  - Tsai, H. F.
AU  - Washburn, R. G.
AU  - Chang, Y. C.
AU  - Kwon-Chung, K. J.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997///
VL  - 26
IS  - 1
SP  - 175
EP  - 183
SN  - 0950-382X
AD  - Tsai, H. F.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19981201500.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 9007-36-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - Conidial colour mutants of A. fumigatus exhibited significant increases in C3 binding capacity compared with wild type. A reddish-pink mutation that led to enhanced C3 binding was complemented by a cosmid clone. A 3.3kb DNA fragment from the subsequently rescued cosmid was sufficient to restore the bluish-green conidial pigment. The bluish-green transformant exhibited a level of C3 binding similar to that of the parental strain. A gene, designated arp1, was responsible for the complementation. Comparison of the genomic and cDNA sequences of arp1 revealed that it has 2 introns and encodes a putative protein of 168 amino acids. Arp1 is very similar to scytalone dehydratase, an enzyme involved in 1,8-dihydroxynaphthalene-melanin synthesis in Colletotrichum lagenarium and Magnaporthe grisea. Northern hybridization analysis revealed that arp1 is developmentally regulated, being expressed during conidiation. Disruption of arp1 resulted in reddish-pink conidia and increased C3 binding. It is suggested that arp1 modulates the bluish-green pigmentation of conidia as well as complement deposition.
KW  - binding
KW  - complement
KW  - conidia
KW  - genes
KW  - mutants
KW  - pigmentation
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - complement binding
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201500&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Americans' knowledge of cancer risk and survival.
AU  - Breslow, R. A.
AU  - Sorkin, J. D.
AU  - Frey, C. M.
AU  - Kessler, L. G.
JO  - Preventive Medicine
JF  - Preventive Medicine
Y1  - 1997///
VL  - 26
IS  - 2
SP  - 170
EP  - 177
SN  - 0091-7435
AD  - Breslow, R. A.: Applied Research Branch, National Cancer Institute, EPN-313, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19982004968.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref.
N2  - Results are given of a interview survey, completed by 12 035 individuals in 1992 in the USA as part of the National Health Interview Survey (NHIS). Respondents' knowledge of cancer risk factors and prospects of survival were determined using sex-appropriate questions and multiple-choice flash-card lists; respondents' access to medical care was also elicited. Among women, 70% correctly identified family history as a risk factor for cancer (men identified this less frequently) and age was identified as a risk factor by about 25% of the women. Only 35% of women identified multiple sexual partners as a risk factor for cervical cancer; the knowledge was particularly low among younger women. The percentage of women who identified age as a risk factor for breast and colon cancer decreased from 25-34 years and 35-44 years of age, respectively to age ≥75 years of age. For prostate cancer, the percentage of men who identified age as a risk factor increased between 35 and 44 years of age and remained at &gt;50% to 75 years of age, the highest level of identification of age as a risk factor for any of the cancers among men or among women. Only about one-third of all respondents knew of the relationship between diet and cancer. Identification of risk factors tended to be lowest among those who were black or Hispanic, had the lowest income, the lowest education or no usual source of medical care. Demographic patterns for the proportion of respondents stating that chances of survival were good were similar to patterns for knowledge about risk factors. It is concluded that this survey emphasises the need for education about risk factors for cancer and the prospects of survival following early detection in the USA.
KW  - human diseases
KW  - knowledge
KW  - neoplasms
KW  - risk factors
KW  - survival
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004968&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intrauterine device use and endometrial cancer risk.
AU  - Sturgeon, S. R.
AU  - Brinton, L. A.
AU  - Berman, M. L.
AU  - Mortel, R.
AU  - Twiggs, L. B.
AU  - Barrett, R. J.
AU  - Wilbanks, G. D.
AU  - Lurain, J. R.
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1997///
VL  - 26
IS  - 3
SP  - 496
EP  - 500
SN  - 0300-5771
AD  - Sturgeon, S. R.: Environmental Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN443, Bethesda, Maryland 20852, USA.
N1  - Accession Number: 19972008473.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Public Health
N2  - The relation between use of an intrauterine device (IUD) and endometrial cancer risk was examined using data from a US multicentre case-control study involving 405 endometrial cancer cases (aged 20-74 years) identified between June 1987 and May 1990 and 297 population controls. 20 (4.9%) cases and 34 (11.4%) controls reported any use of an IUD. After adjustment for potential confounders. IUD use was not associated with an increased risk of endometrial cancer (RR=0.56 for ever use; 95% CI: 0.3-1.0). Little reduction in risk was observed among women who last used an IUD within 10 years of the index date (RR=0.84; 95% CI: 0.3-2.4) but risk was decreased among women who used an IUD in the more distant past (RR=0.45; 95% CI: 0.2-1.0). Risk did not vary consistently with number of years of IUD use or with years since first use. Risk was not increased among women who used inert devices (RR=0.46; 95% CI: 0.3-3.6) or those who used devices containing copper (RR=1.08; 95% CI: 0.1-3.6). It is concluded that these data do not provide any evidence of an increased risk of endometrial cancer among women who have used IUD.
KW  - contraceptives
KW  - endometrial cancer
KW  - endometrium
KW  - epidemiology
KW  - human diseases
KW  - intrauterine devices
KW  - neoplasms
KW  - risk factors
KW  - women
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancer sites
KW  - cancers
KW  - endometrial area
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008473&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transmission-blocking vaccines: uses and current status of development.
AU  - Kaslow, D. C.
A2  - Andrews, R. H.
JO  - International Journal for Parasitology
JF  - International Journal for Parasitology
Y1  - 1997///
VL  - 27
IS  - 2
SP  - 183
EP  - 189
SN  - 0020-7519
AD  - Kaslow, D. C.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970501175.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology
N2  - An intensive effort to develop subunit vaccines for malaria targeted at various stages of the Plasmodium life cycle has been undertaken. One such vaccine, directed against the sexual and sporogonic stages and referred to as a transmission-blocking vaccine, offers the hope of controlling malaria in geographically isolated areas, preventing re-introduction of the parasite in malaria-free zones, blocking the spread of drug-resistant or vaccine escape mutants, and reducing exposure to "virulent" strains of parasites. A series of potential transmission-blocking vaccine candidates have been identified and the genes encoding these surface proteins have now been isolated and sequenced. One such vaccine candidate, Pfs25, is now being tested in human Phase I safety and immunogenicity studies. Here, the use and status of transmission-blocking vaccines are reviewed.
KW  - antigens
KW  - disease transmission
KW  - disease vectors
KW  - gametes
KW  - gametocytes
KW  - human diseases
KW  - malaria
KW  - oocysts
KW  - ookinetes
KW  - parasites
KW  - reviews
KW  - transmission blocking antibodies
KW  - transmission blocking immunity
KW  - vaccines
KW  - zygotes
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - man
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Plasmodium
KW  - antigenicity
KW  - Australian and New Zealand Societies for Parasitology Scientific Meeting
KW  - immunogens
KW  - mosquitoes
KW  - transmission blocking vaccines
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501175&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trends in food intake: the 1987 and 1992 national health interview surveys.
AU  - Breslow, R. A.
AU  - Subar, A. F.
AU  - Patterson, B. H.
AU  - Block, G.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1997///
VL  - 28
IS  - 1
SP  - 86
EP  - 92
SN  - 0163-5581
AD  - Breslow, R. A.: Applied Research Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001412819.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - To examine food intake trends in the US population, cross-sectional nationally representative food intake data were obtained from the 1987 and 1992 National Health Interview Survey Cancer Control Supplements. In each of these years, approximately 10 000 respondents completed methodologically consistent food frequency questionnaires containing the same 57 food items. Between 1987 and 1992, the proportion of Americans consuming high-fat foods, including fried fish, fried chicken, bacon, eggs, whole milk, and butter, decreased. The proportion of Americans drinking alcoholic beverages also decreased: fewer drank wine and hard liquor in 1992. The proportion of fruit and vegetable consumers remained stable over time. These results are similar to those obtained from more detailed national surveys. National guidelines urge Americans to avoid intake of high-fat foods, increase consumption of fruits and vegetables, and practice moderation when drinking alcoholic beverages to prevent cancer and other chronic diseases. The direction of Americans' apparent changes in food usage between 1987 and 1992, evaluated using limited data from food frequency questionnaires, suggests greater behavioural changes in the direction of guidelines recommending avoidance of foods that may increase the risk of cancer than in the direction of guidelines recommending increased consumption of foods that may confer protection.
KW  - alcoholic beverages
KW  - bacon
KW  - behavioural changes
KW  - beverages
KW  - butter
KW  - consumption
KW  - diet studies
KW  - dietary surveys
KW  - distilled spirits
KW  - eggs
KW  - food consumption
KW  - food intake
KW  - foods
KW  - fried foods
KW  - fruits
KW  - milk
KW  - milk consumption
KW  - vegetables
KW  - wines
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - behavior change
KW  - drinks
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Milk and Dairy Produce (QQ010) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412819&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular phylogeny of the genus Entamoeba as revealed by riboprinting.
AU  - Clark, C. G.
AU  - Diamond, L. S.
JO  - Archives of Medical Research
JF  - Archives of Medical Research
Y1  - 1997///
VL  - 28
IS  - Special Issue
SP  - S69
EP  - S70
SN  - 0066-6769
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19970802424.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 5 ref. Subject Subsets: Protozoology
KW  - amoebiasis
KW  - genes
KW  - human diseases
KW  - molecular genetics
KW  - molecular taxonomy
KW  - parasites
KW  - phylogeny
KW  - Entamoeba
KW  - protozoa
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - amebiasis
KW  - biochemical genetics
KW  - small subunit ribosomal RNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802424&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cholesterol requirement and metabolism in Entamoeba histolytica.
AU  - Luján, H. D.
AU  - Diamond, L. S.
JO  - Archives of Medical Research
JF  - Archives of Medical Research
Y1  - 1997///
VL  - 28
IS  - Special Issue
SP  - S96
EP  - S97
SN  - 0066-6769
AD  - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892-045, USA.
N1  - Accession Number: 19970802436.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 5 ref. Registry Number: 57-88-5.  Subject Subsets: Protozoology
KW  - amoebiasis
KW  - biochemistry
KW  - cholesterol
KW  - cholesterol metabolism
KW  - human diseases
KW  - parasites
KW  - Entamoeba histolytica
KW  - protozoa
KW  - Entamoeba
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - amebiasis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract.
AU  - Cott, J. M.
A2  - Müller, W. E.
A2  - Kaper, S.
JO  - Pharmacopsychiatry
JF  - Pharmacopsychiatry
Y1  - 1997///
VL  - 30
IS  - SUP 2
SP  - 108
EP  - 112
AD  - Cott, J. M.: National Institute of Mental Health (NIMH), 5600 Fishers Lane, Room 18-105, Rockville, Maryland 20857, USA.
N1  - Accession Number: 19980308154.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 37 ref. Subject Subsets: Horticultural Science
N2  - Hypericum perforatum (St. John's wort) has been used since the time of ancient Greece for its many medicinal properties. Modern usage is still quite diverse and includes promotion of wound healing, and treatment of kidney and lung ailments, insomnia and depression. This plant has been known to contain a red pigment, hypericin, and similar compounds, which have been assumed to be the primary active constituent(s). A crude Hypericum extract was tested in a battery of 39 in vitro receptor assays, and 2 enzyme assays. A sample of pure hypericin was also tested. Hypericin had affinity only for NMDA receptors while the crude extract had significant receptor affinity for adenosine (nonspecific), GABAA, GABAB, benzodiazepine, inositol triphosphate and monoamine oxidase A and B. With the exception of GABAA and GABAB, the concentrations of Hypericum extract required for these in vitro activities were unlikely to be attained after oral administration to animals or man. These data are consistent with recent pharmacologic evidence suggesting that other constituents of this plant may be of greater importance for the reported psychotherapeutic activity. Alternative pharmacologic mechanisms for Hypericum's antidepressant activity are critically reviewed and the possible importance of GABA receptor binding in the pharmacology of Hypericum is highlighted.
KW  - enzyme activity
KW  - enzymes
KW  - herbal drugs
KW  - medicinal plants
KW  - medicinal properties
KW  - nervous system
KW  - pharmacology
KW  - plant composition
KW  - plant extracts
KW  - receptors
KW  - Hypericum perforatum
KW  - Hypericum
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - chemical constituents of plants
KW  - drug plants
KW  - herbal medicines
KW  - Hypericum extract (LI 160) as a herbal antidepressant
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980308154&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of exercise training in a cold environment on thermoregulation in adult and aged C57BL/6J mice.
AU  - Shefer, V. I.
AU  - Talan, M. I.
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1997///
VL  - 32
IS  - 6
SP  - 695
EP  - 705
SN  - 0531-5565
AD  - Shefer, V. I.: Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA.
N1  - Accession Number: 19981407636.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
N2  - The effect of exercise training in cold environment (six weeks of daily, one-hour runs on a treadmill at ambient temperature of 6 ± 1°C at 60-65% of VO2max) on cold-induced metabolic heat production, heat loss, and cold tolerance was studied in adult and aged C57BL/6J male mice. The training resulted in greater cold-induced heat production and cold tolerance without changes in heat loss, similar to the effects of daily cold exposure without exercise. In aged mice, daily cold exposures did not affect cold tolerance and cold-induced heat production, but exercise training in the cold resulted in greater cold-induced heat production and cold tolerance. Heat loss in aged mice increased similarly after both repeated cold exposures and exercise training in the cold. Therefore, mechanisms of effect of exercise training on cold tolerance are different in adult and aged animals. Exercise training in cold environment does not affect cold-induced heat production and cold tolerance in adult mice, but improves them in aged animals.
KW  - aging
KW  - body temperature
KW  - cold
KW  - cold resistance
KW  - cold tolerance
KW  - elderly
KW  - energy exchange
KW  - environmental temperature
KW  - exercise
KW  - heat loss
KW  - heat production
KW  - heat retention
KW  - old age
KW  - physical activity
KW  - training
KW  - man
KW  - rats
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - aged
KW  - ageing
KW  - calorigenesis
KW  - cold hardiness
KW  - elderly people
KW  - older adults
KW  - senior citizens
KW  - thermogenesis
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407636&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Proceeding of the second international conference on animal models for aging research, Kyoto, Japan, 12-19 May, 1995.
A2  - Sprott, R. L.
A2  - Takeda, T.
A2  - Rocha, C. A.
T2  - Experimental Gerontology
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1997///
VL  - 32
IS  - 1/2
SP  - 1
EP  - 242
SN  - 0531-5565
AD  - Biology of Aging Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave., Gateway Bldg., Rm. 2C231, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971408987.  Publication Type: Conference proceedings.  Language: English.  Number of References: many ref. Subject Subsets: Human Nutrition
N2  - This special double issue contains 23 papers that were presented at the conference entitled: biogerontologic theories; genetic influences on aging; comparative aging with life histories in mammals; experimental design and husbandry; prospects for quantitative trait locus methodology in gerontology; issues in the choice of genetic configuration for animal aging models; selection for maximum longevity in mice; mouse and rat genotype choices; biomarkers of age and aging; expression of endothelin, fibronectin, and mortalin as aging and mortality markers; senescence-accelerated mouse (SAM): a novel murine model of senescence; management and design of the maintenance of SAM strains: an animal model for accelerated senescence and age-associated disorders; pathobiology of the SAM; genetic characterization of SAM; characteristics of age-related behavioral changes in SAMP8 and SAMP10; beneficial effects of aged garlic extract on learning and memory impairment in the SAM; neuropathological studies on strains of SAM with age-related deficits in learning and memory; effect of acidic fibroblast growth factor on basal forebrain cholergic neurons in SAM; immune abnormality in relation to non-immune diseases in SAM; in vitro study of the mechanisms of senescence acceleration; diet and calorie restriction; pathobiology of aging rodents: inbred and hybrid models; and herbal medicine and the study of aging in SAM (SAMP1TA/Ngs). The 16th and 21st papers are abstracted elsewhere in this issue of NAR/A.
KW  - age
KW  - aging
KW  - animal models
KW  - brain
KW  - diet
KW  - energy deprivation
KW  - experimental design
KW  - extracts
KW  - garlic
KW  - genetics
KW  - geriatrics
KW  - growth factors
KW  - immunity
KW  - learning
KW  - longevity
KW  - markers
KW  - medicinal plants
KW  - memory
KW  - models
KW  - mortality
KW  - neurons
KW  - selection
KW  - Allium sativum
KW  - mammals
KW  - mice
KW  - Allium
KW  - Alliaceae
KW  - Liliaceae
KW  - Liliales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - ageing
KW  - cerebrum
KW  - death rate
KW  - drug plants
KW  - gerontology
KW  - medicinal herbs
KW  - nerve cells
KW  - neurones
KW  - officinal plants
KW  - plot design
KW  - second international conference on animal models for aging research
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408987&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diet and calorie restriction.
AU  - Sprott, R. L.
A2  - Sprott, R. L.
A2  - Takeda, T.
A2  - Rocha, C. A.
JO  - Experimental Gerontology
JF  - Experimental Gerontology
Y1  - 1997///
VL  - 32
IS  - 1/2
SP  - 205
EP  - 214
SN  - 0531-5565
AD  - Sprott, R. L.: The Biology of Aging Program, The National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave., Gateway Bldg., Suite 2C231, Bethesda, Maryland 20892 USA.
N1  - Accession Number: 19971408915.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 7 ref. Subject Subsets: Human Nutrition
N2  - This paper briefly reviews on the effects of energy restriction on a variety of functional measures and on age-dependent tumours and lesions. The effects of energy restriction on the probability of survival and mean body weight of C57BL/6N, DBA/2N, B6xD2F1 and B6xC3F1 mice and F344, Brown Norway and F344xBN rats of both sexes are presented graphically. Recommendations for energy restriction, or at least "dietary control," are discussed.
KW  - aging
KW  - animal models
KW  - body weight
KW  - energy deprivation
KW  - models
KW  - reviews
KW  - sex differences
KW  - survival
KW  - mice
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - second international conference on animal models for aging research
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408915&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of bovine immunodeficiency virus by anti-HIV-1 compounds in a cell culture-based assay.
AU  - Tobin, G. J.
AU  - Ennis, W. H.
AU  - Clanton, D. J.
AU  - Gonda, M. A.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1997///
VL  - 33
IS  - 1
SP  - 21
EP  - 31
SN  - 0166-3542
AD  - Tobin, G. J.: Laboratory of Cell and Molecular Structure, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001493.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 9007-49-2. 
N2  - A cell culture-based antiviral assay was developed to test compounds for inhibition of BIV replication. The assay uses an embryonic rabbit epithelial (EREp) cell line that is highly sensitive to BIV infection and cytopathology. The 50% effective concentrations (EC50) at which the virus was inhibited in EREp cells were determined for 13 nucleoside analogue, non-nucleoside, tumour-suppressive, or membrane-surface inhibitory compounds. The nucleoside analogues (3′-azido-2′,3′-dideoxythymidine, 2′,3′-dideoxyinosine and 2′,3′-dideoxycytosine), surface-membrane inhibitors (dextran sulfate, hypericin, Chicago Sky Blue and quinobene), the nucleoside reductase inhibitor (hydroxyurea), and a tumour-suppressive phorbol ester (prostratin) inhibited BIV with EC50 values similar to those derived in HIV-1 lymphocyte (CD4+)-based assays. BIV was markedly more resistant to inhibition with HIV-1-specific non-nucleoside reverse transcriptase inhibitors (NNRTIs) (thiazolobenzimidazole, oxathiin carboxanilide and thiocarbamate) than was HIV-1, which parallels results with NNRTIs in HIV-2 assays.
KW  - analogues
KW  - antiviral agents
KW  - cell lines
KW  - DNA
KW  - enzyme inhibitors
KW  - genomes
KW  - hiv infections
KW  - human diseases
KW  - inhibition
KW  - inhibitors
KW  - lymphocytes
KW  - microbiology
KW  - nucleoside analogues
KW  - nucleosides
KW  - nucleotide sequences
KW  - replication
KW  - resistance
KW  - reverse transcriptase inhibitors
KW  - bovine immunodeficiency virus
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - Lentivirus
KW  - rabbits
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - non-nucleoside reverse transcriptase inhibitors
KW  - nucleoside analogs
KW  - other Retroviridae
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001493&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV).
AU  - Gulakowski, R. J.
AU  - McMahon, J. B.
AU  - Buckheit, R. W. Jr.
AU  - Gustafson, K. R.
AU  - Boyd, M. R.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1997///
VL  - 33
IS  - 2
SP  - 87
EP  - 97
SN  - 0166-3542
AD  - Gulakowski, R. J.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972002642.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 9026-43-1, 9068-38-6. 
N2  - Prostratin inhibited HIV-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression in two latently-infected cell lines, but had little or no effect on chronically-infected cell lines. Prostratin caused a dose-dependent, but reversible, decrease in CD4 expression in the CEM-SS and MT-2 cell lines. This down-regulation of CD4 was inhibited in a dose-dependent manner by the protein kinase C (PKC) antagonist, staurosporine. Prostratin had no effect on reverse transcriptase or HIV-1 protease, nor did it inhibit the binding of gp120 to CD4.
KW  - antiviral agents
KW  - CD4 antigens
KW  - cytopathogenicity
KW  - effects
KW  - envelope protein gp120
KW  - esters
KW  - HIV-1 infections
KW  - hosts
KW  - human diseases
KW  - kinases
KW  - microbiology
KW  - protein kinase
KW  - replication
KW  - reverse transcriptase
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - gp120
KW  - human immunodeficiency virus type 1
KW  - other agents
KW  - phorbol
KW  - prostratin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002642&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alcohol's impact upon glycobiology.
AU  - Lands, W. E. M.
JO  - Indian Journal of Biochemistry & Biophysics
JF  - Indian Journal of Biochemistry & Biophysics
Y1  - 1997///
VL  - 34
IS  - 1/2
SP  - 212
EP  - 213
SN  - 0301-1208
AD  - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, NIH, 6000 Executive Blvd MSC 7003, Bethesda MD 20892-7003, USA.
N1  - Accession Number: 19981400756.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 64-17-5.  Subject Subsets: Human Nutrition
N2  - This paper briefly reviews ways in which some of the diseases (cardiovascular diseases, liver diseases, neuropathological illness and fetal injury) linked to excessive alcohol intake may develop from alcohol-induced alterations of cell surface molecules.
KW  - alcoholic beverages
KW  - cardiovascular diseases
KW  - cell membranes
KW  - cirrhosis
KW  - ethanol
KW  - fetus
KW  - injuries
KW  - liver diseases
KW  - nervous system diseases
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ethyl alcohol
KW  - foetus
KW  - liver cirrhosis
KW  - neuropathy
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400756&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance.
AU  - Walsh, T. J.
AU  - Kasai, M.
AU  - Francesconi, A.
AU  - Landsman, D.
AU  - Chanock, S. J.
JO  - Journal of Medical and Veterinary Mycology
JF  - Journal of Medical and Veterinary Mycology
Y1  - 1997///
VL  - 35
IS  - 2
SP  - 133
EP  - 137
SN  - 0268-1218
AD  - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971201109.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - To identify potential target sequences that may be derived from candidate genes that share homology with the ATP binding cassette region of the human MDR-1 P-glycoprotein, degenerate oligonucleotide primers based on the known sequence from the ATP binding cassette region of the human MDR-1 P-glycoprotein were used to amplify polymerase chain reaction (PCR) products within the range of 100 bp in length from C. albicans isolates (3 fluconazole-susceptible and 3 fluconazole-resistant). Sequence analysis of individually subcloned PCR products, derived from the 6 isolates revealed 34 sequences in total. The results identified 14 clones (with at least 1 per isolate) with a high degree of homology to the ATP binding cassette of the human MDR-1 P-glycoprotein. A BLAST search did not disclose homology of these new sequences to the C. albicans CDR1 gene, indicating that C. albicans may possess &gt;1 MDR-like gene. It is concluded that C. albicans may possess one or more additional genes encoding ATP binding cassette MDR-like proteins that are distinct from CDR1 and which could participate in the development of fluconazole resistance.
KW  - antifungal agents
KW  - drug resistance
KW  - fluconazole
KW  - fungicides
KW  - genes
KW  - genetics
KW  - resistance
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Absence of tetrodotoxins in a captive-raised riparian frog, Atelopus varius.
AU  - Daly, J. W.
AU  - Padgett, W. L.
AU  - Saunders, R. L.
AU  - Cover, J. F., Jr.
JO  - Toxicon (Oxford)
JF  - Toxicon (Oxford)
Y1  - 1997///
VL  - 35
IS  - 5
SP  - 705
EP  - 709
SN  - 0041-0101
AD  - Daly, J. W.: Laboratory of Bioorganic Chemistry, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010447.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Tropical Diseases
KW  - physiology
KW  - skin
KW  - toxins
KW  - Panama
KW  - frogs
KW  - Anura
KW  - Amphibia
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central America
KW  - America
KW  - Developing Countries
KW  - Latin America
KW  - Threshold Countries
KW  - Atelopus varius
KW  - dermis
KW  - tetrodotoxins
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Laboratory diagnosis of respiratory virus infections in 24 hours by utilizing shell vial cultures.
AU  - Engler, H. D.
AU  - Preuss, J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1997///
VL  - 35
IS  - 8
SP  - 2165
EP  - 2167
SN  - 0095-1137
AD  - Engler, H. D.: Microbiology Service, Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1058, USA.
N1  - Accession Number: 19982005384.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Public Health
N2  - During February 1995-January 1997, 603 clinical specimens from mainly immunocompromised patients at the Clinical Center of the National Institutes of Health, Bethesda, MD, USA, were submitted for respiratory virus (RV) culture. Laboratory diagnosis was performed by immunofluorescence staining of centrifugation-enhanced shell vial (SV) cultures. The procedure, which required only a 24 h incubation period, permitted the detection of 77% of the RV-positive specimens that would ordinarily not have been detected as positive until 48 h. Staining SVs at 24 h also permitted earlier detection of viruses that were missed by rapid antigen detection methods.
KW  - culture techniques
KW  - detection
KW  - diagnosis
KW  - human diseases
KW  - parainfluenza viruses
KW  - respiratory diseases
KW  - viral diseases
KW  - Maryland
KW  - USA
KW  - human adenovirus
KW  - human respiratory syncytial virus
KW  - Influenza B virus
KW  - influenzavirus A
KW  - influenzavirus B
KW  - man
KW  - Mastadenovirus
KW  - Adenoviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Pneumovirus
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Pneumovirinae
KW  - Influenzavirus B
KW  - Orthomyxoviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Paramyxovirinae
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - lung diseases
KW  - parainfluenza virus
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of the hybrid capture tube test and PCR for detection of human papillomavirus DNA in cervical specimens.
AU  - Cope, J. U.
AU  - Hildesheim, A.
AU  - Schiffman, M. H.
AU  - Manos, M. M.
AU  - Lörincz, A. T.
AU  - Burk, R. D.
AU  - Glass, A. G.
AU  - Greer, C.
AU  - Buckland, J.
AU  - Helgesen, K.
AU  - Scott, D. R.
AU  - Sherman, M. E.
AU  - Kurman, R. J.
AU  - Liaw, K. L.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1997///
VL  - 35
IS  - 9
SP  - 2262
EP  - 2265
SN  - 0095-1137
AD  - Cope, J. U.: Division of Cancer Epidemiology & Genetics, National Cancer Institute, EPN Rm 439, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982004682.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9007-49-2.  Subject Subsets: Public Health
N2  - Two DNA methods that are commonly used for HPV research in the USA were compared: the MY09/MY11 L1 consensus primer PCR-based test and the first-generation Hybrid Capture tube method (HCT). Laboratory assays by each method were performed with 596 cervicovaginal specimens collected from participants in a large cohort study conducted in Portland, Oregon. Included were 499 specimens from women whose cytology was normal and 97 specimens from women with squamous intraepithelial lesions (SILs). The overall HPV DNA positivity for known types was 22.5% by PCR compared to 13.6% by HCT. When the analysis was restricted to the 14 HPV types detectable by both methods, the sensitivity of HCT, with PCR used as the standard for HPV status, was higher for specimens from women with concurrent SILs (81.0%) than for specimens from women with normal cytology (46.7%). Among specimens testing positive by both methods, 97.2% of the time the two methods agreed on whether specimens were positive for cancer-associated HPV types. Both of these HPV test methods provide information that supplements the information provided by the Pap smear. In conclusion, the PCR method has higher analytic sensitivity than HCT in detecting HPV, but HCT may be helpful in identifying women with concurrent SILs.
KW  - assays
KW  - cervical cancer
KW  - cervix
KW  - detection
KW  - DNA
KW  - human diseases
KW  - hybrids
KW  - laboratory methods
KW  - lesions
KW  - methodology
KW  - neoplasms
KW  - polymerase chain reaction
KW  - specimens
KW  - women
KW  - USA
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Papillomaviridae
KW  - cancers
KW  - deoxyribonucleic acid
KW  - human papillomavirus
KW  - laboratory techniques
KW  - methods
KW  - Papovaviridae
KW  - PCR
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of commercially available and in-house reverse transcription-PCR assays for detection of hepatitis G virus or GB virus C.
AU  - Forns, X.
AU  - Tan, D.
AU  - Alter, H. J.
AU  - Purcell, R. H.
AU  - Bukh, J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1997///
VL  - 35
IS  - 10
SP  - 2698
EP  - 2702
SN  - 0095-1137
AD  - Forns, X.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Dr., MSC 0740, Bethesda, MD 20892-0740, USA.
N1  - Accession Number: 19982006672.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref.
N2  - Serum samples from 96 Spanish haemodialysis patients [date not given], as well as serial dilutions of RNA extracted from a reference strain of hepatitis G virus (HGV), were tested for HGV or GB virus C (GBV-C) RNA. Two different reverse transcription (RT)-PCR-based methods of detection were compared for the ability to detect RNA extracted from the samples: an RT-nested PCR assay with primers derived from the 5′ noncoding region (5′NC) or nonstructural region 3 (NS3) sequences and a commercially available RT-PCR assay with primers derived from the 5′NC or NS5A sequences. When RT-nested PCR was performed on 10-fold serial dilutions of RNA from the HGV reference strain, the last positive dilution was 10-7-10-8. With the commercial RT-PCR assay, the last positive dilution was 10-6-10-7. When equal amounts of RNA extracted from serum samples from 96 haemodialysis patients were tested for HGV or GBV-C RNA, 25 patients (26%) were positive by the RT-nested PCR. However, only 21 (84%) of these 25 positive patients were positive for HGV or GBV-C by the commercial RT-PCR assay. Analysis of the 5′NC and NS3 sequences amplified by RT-nested PCR demonstrated that all but 2 positive patients had unique HGV or GBV-C sequences. It is concluded that RT-nested PCR and a commercially available RT-PCR assay for HGV or GBV-C gave concordant results for 96% of the patients tested.
KW  - blood
KW  - detection
KW  - diagnosis
KW  - hepatitis
KW  - hepatitis g
KW  - human diseases
KW  - polymerase chain reaction
KW  - viral diseases
KW  - Spain
KW  - hepatitis g virus
KW  - man
KW  - viruses
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - hepatitis GB virus c
KW  - PCR
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quantitative urine cultures do not reliably detect renal candidiasis in rabbits.
AU  - Navarro, E. E.
AU  - Almario, J. S.
AU  - Schaufele, R. L.
AU  - Bacher, J.
AU  - Walsh, T. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1997///
VL  - 35
IS  - 12
SP  - 3292
EP  - 3297
SN  - 0095-1137
AD  - Navarro, E. E.: Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981200135.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - To determine the significance of quantitative urine cultures in renal candidosis, serial quantitative urinary cultures of Candida albicans in a rabbit model of haematogenous infection were studied. Of 197 urine samples from 34 infected animals, 144 were culture-positive, with a sensitivity of 73.1% for urine cultures and a lower limit of detection of 10 colony forming units (CFU)/ml. The yield of urine cultures varied according to severity and duration of infection. The mean renal and urinary concentrations of C. albicans from rabbits with subacute candidosis differed significantly from those from rabbits with acute candidosis (P=0.013 and P≤0.001, respectively). During the first 4 days of subacute renal candidosis, &gt;50% of all urine cultures were negative for C. albicans. Only 12 (8.1%) of 148 urine cultures in animals with subacute renal candidosis had concentrations of &gt;10³ CFU/ml, 2.7% had concentrations of &gt;104 CFU/ml and none were ≥105 CFU/ml. In comparison, all urine cultures from the animals with lethal acute renal candidosis had higher concentrations of C. albicans and were positive throughout the course of infection. Urinary concentrations of C. albicans were not predictive of the amount of Candida in the kidney (r≤0.49) and did not correlate with survival (r=0.0232), although the renal concentration of C. albicans (in CFU/g) inversely correlated with the duration of survival (in days) of rabbits with renal candidosis (r=0.76; P&lt;0.001). It is concluded that a negative urine culture in rabbits does not preclude the presence of renal candidosis. The interpretation of a urine culture positive at any concentration, however, must involve an analysis of the risk factors for renal candidosis, for any urinary concentration of C. albicans may reflect kidney infection.
KW  - candidosis
KW  - cultures
KW  - diagnosis
KW  - disease models
KW  - experimental infections
KW  - infections
KW  - isolation
KW  - kidneys
KW  - urine
KW  - Candida albicans
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - candidiasis
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200135&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 acquires resistance to two classes of antiviral drugs through homologous recombination.
AU  - Yusa, K.
AU  - Kavlick, M. F.
AU  - Kosalaraksa, P.
AU  - Mitsuya, H.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1997///
VL  - 36
IS  - 3
SP  - 179
EP  - 189
SN  - 0166-3542
AD  - Yusa, K.: The Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bld. 10, Room 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982002477.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9068-38-6, 30516-87-1. 
N2  - This study demonstrates that HIV-1 readily develops resistance to 2 classes of anti-HIV-1 drugs through in vitro genetic recombination involving large segments of the viral genome. Co-transfection of COS-7 cells with an HIV-1 plasmid (pSUM13) carrying 5 mutations in the reverse transcriptase (RT)-encoding region (A62V, V75I, F77L, F116Y, Q151M), conferring resistance to multiple dideoxynucleoside analogues (ddNs), and another HIV-1 plasmid (pSUM431) carrying five mutations in the protease-encoding region (V32I, L33F, K45I, I84V, L89M), conferring resistance to protease inhibitors such as KNI-272, readily produced HIV-1 carrying both sets of mutations when propagated in MT-2 cells in the presence of azidothymidine (AZT) and KNI-272. The resultant HIV-1 variant was highly resistant to both ddNs and KNI-272. Co-infection of MT-2 cells with HIV-1SUM13 carrying the RT mutations and HIV-1SUM431 carrying the mutations in the protease also generated HIV-1 with both sets of mutations when cultured with AZT and KNI-272.
KW  - analogues
KW  - antiviral agents
KW  - drug resistance
KW  - drugs
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - inhibitors
KW  - mutations
KW  - nucleoside analogues
KW  - nucleosides
KW  - polymerase chain reaction
KW  - proteinase inhibitors
KW  - proteinases
KW  - reverse transcriptase
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - AZT
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - medicines
KW  - nucleoside analogs
KW  - PCR
KW  - pharmaceuticals
KW  - protease inhibitors
KW  - proteases
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay.
AU  - Ueno, T.
AU  - Mitsuya, H.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1997///
VL  - 36
IS  - 5
SP  - 1092
EP  - 1099
SN  - 0006-2960
AD  - Ueno, T.: Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972003049.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 7841-89-2, 9007-49-2, 9068-38-6, 63231-63-0. 
N2  - Employing the single-nucleotide incorporation assay using a heteropolymeric RNA template and DNA primers, enzymatic profiles were defined of recombinant HIV-1 reverse transcriptase (RT) containing a set of 5 mutations [A62V, V75I, F77L, F116Y, and Q151M] which confers resistance to multiple 2′,3′-dideoxynucleosides (ddNs) on HIV-1. RTs containing other drug-resistance-associated mutations were also examined. The Km for dNTPs, the kcat, and the kcal/Km ratios of mutant RTs were all comparable to those of wild-type RT (RTwt). The processive primer extension activity of mutant RTs was also comparable to that of RTwt as examined in the presence of saturating concentrations of dNTPs and heparin. Determination of the Ki values toward 5′-triphosphates (TP) of various ddNs [3′-azido-2′,3′-dideoxythymidine (AZT), 2′,3′-didehydro-2′-3′-dideoxythymidine (D4T), 2′,3′-dideoxycytidine (ddC), (-)-β-L-2′,3′-dideoxy-3′-thiacytidine (3TC), (-)-β-L-2′,3′-dideoxy-5-fluorocytidine (FddC), 2′,3′-dideoxyadenosine (ddA), and 2′-β-fluoro-2′,3′-dideoxyadenosine (FddA)] and 9-(2-phosphonylmethoxyethyl)adenine diphosphate (PMEApp) revealed that RTA62V/V75I/F77L/F116Y/Q151M was insensitive to ddATP, AZTTP, D4TTP, FddATP and ddCTP, but was sensitive to PMEApp, 3TCTP and FddCTP. RTK65R was less sensitive to ddATP, FddATP, PMEApp, ddCTP and 3TCTP, while RTM184V was less sensitive only to 3TCTP and ddCTP. The determination of Ki(ddNTP)/Km(dNTP) ratios showed that AZTTP, D4TTP and ddCTP are, as substrates, as efficient for RTwt as their corresponding dNTPs, that ddATP, PMEApp and 3TCTP are moderately efficient substrates for RTwt, and that FddATP is the least efficient substrate among ddNTPs examined. The observed cross-resistance of HIV-1 RT to various ddNTPs should reflect the alteration of RT's substrate recognition and should provide insights into the molecular mechanism of RT discrimination of ddNTPs from natural substrates.
KW  - antiviral agents
KW  - biochemistry
KW  - dideoxycytidine
KW  - DNA
KW  - enzyme inhibitors
KW  - molecular biology
KW  - molecular genetics
KW  - mutations
KW  - nucleotides
KW  - reverse transcriptase
KW  - reverse transcriptase inhibitors
KW  - RNA
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resistance pattern of 2816 isolates from 17 631 blood cultures and etiology of bacteremia and fungemia in a single cancer institution.
AU  - Trupl, J.
AU  - Kunová, A.
AU  - Oravcová, E.
AU  - Pichna, P.
AU  - Kukučková, E.
AU  - Grausova, S.
AU  - Grey, E.
AU  - Spanik, S.
AU  - Demitrovičová, A.
AU  - Kral'ovičová, K.
AU  - Lacka, J.
AU  - Krupova, I.
AU  - Svec, J.
AU  - Koren, P.
AU  - Krčméry, V., Jr.
JO  - Acta Oncologica
JF  - Acta Oncologica
Y1  - 1997///
VL  - 36
IS  - 6
SP  - 643
EP  - 649
SN  - 0001-6381
AD  - Trupl, J.: Department of Microbiology, National Cancer Institute, Bratislava, Slovakia.
N1  - Accession Number: 19981201485.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 86386-73-4, 82419-36-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - The resistance pattern of 2816 isolates from 17 631 blood cultures and the aetiology of isolates causing bacteraemia and fungaemia among 14 591 admissions were investigated in an 80-bed single cancer institute in Bratislava, Slovakia, during 1990-96, under the same empiric therapeutic antibiotic policy but with different prophylactic strategies. No change was found in the proportion of Gram positive vs. Gram negative bacterial isolates from bacteraemia (70% vs. 30%) during the 7-year period. The proportion of coagulase-negative staphylococci and enterococci was approx. the same before and after the introduction of ofloxacin in prophylaxis. The proportion of Pseudomonas aeruginosa and Stenotrophomonas maltophilia causing bacteraemia increased. There was no increase in Candida krusei and C. glabrata [Torulopsis glabrata] after the introduction of fluconazole into prophylactic regimens in 1992. Penicillin-resistance in viridans streptococci increased after penicillin was introduced into prophylaxis in acute leukaemia in 1993. Until 1995 no quinolone-resistant Enterobacteriaceae were observed. Susceptibility to quinolones did not significantly change within the past seven years in Enterobacteriaceae after their introduction to prophylaxis in 1991, but Pseudomonas aeruginosa decreased from 90% to 58.2%. Glycopeptide resistance in enterococci and staphylococci was minimal in the observed period (0.9-4.3%).
KW  - bacteraemia
KW  - bacterial diseases
KW  - blood
KW  - candidosis
KW  - drug resistance
KW  - fluconazole
KW  - fungaemia
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - neoplasms
KW  - ofloxacin
KW  - opportunistic infections
KW  - penicillins
KW  - predisposition
KW  - quinolones
KW  - Slovakia
KW  - Candida acidothermophilum
KW  - Candida glabrata
KW  - Enterobacteriaceae
KW  - man
KW  - Pseudomonas aeruginosa
KW  - Staphylococcus
KW  - Stenotrophomonas maltophilia
KW  - Streptococcus
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudomonas
KW  - Pseudomonadaceae
KW  - Pseudomonadales
KW  - Staphylococcaceae
KW  - Bacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Stenotrophomonas
KW  - Xanthomonadaceae
KW  - Xanthomonadales
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Torulopsis
KW  - Pezizomycotina
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - bacteremia
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - cancers
KW  - Candida krusei
KW  - candidiasis
KW  - fungemia
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Glycosylation affects both the three-dimensional structure and antibody binding properties of the HIV-1IIIB GP120 peptide RP135.
AU  - Huang XiaoLin
AU  - Barchi, J. J., Jr.
AU  - Lung, F. D. T.
AU  - Roller, P. P.
AU  - Nara, P. L.
AU  - Muschik, J.
AU  - Garrity, R. R.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1997///
VL  - 36
IS  - 36
SP  - 10846
EP  - 10856
SN  - 0006-2960
AD  - Huang XiaoLin: Laboratory of Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972009859.  Publication Type: Journal Article.  Language: English.  Number of References: 72 ref.
N2  - Simple O-glycosylation was shown to have significant effects on the conformation of an important peptide epitope from the V3 loop by stabilizing a reverse turn and rigidifying the backbone conformations proximal to the glycosylation sites. These structural adjustments resulted in an enhanced binding to a monoclonal antibody which was raised to HIV-IIIB-infected cells and mapped to the unglycosylated epitope sequence. Studies such as this may be valuable in determining whether the presence of carbohydrates affects the three-dimensional conformation of gp120 subdomains. Additionally, covalently linked glycans may enhance epitope-specific antibody binding of these subdomains and prove useful in the design of glycopeptide-based vaccines.
KW  - antibodies
KW  - binding
KW  - biochemistry
KW  - conformation
KW  - env gene
KW  - envelope protein gp120
KW  - epitopes
KW  - HIV-1 infections
KW  - human diseases
KW  - microbiology
KW  - properties
KW  - structural genes
KW  - structure
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenic determinants
KW  - body conformation
KW  - glycosylation
KW  - gp120
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts.
AU  - Hui, R.
AU  - Everhart, A. L.
AU  - Glasgow, W. C.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1997///
VL  - 38
IS  - 1
SP  - 49
EP  - 60
SN  - 0022-2275
AD  - Hui, R.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19971403024.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 60-33-3, 9026-43-1.  Subject Subsets: Human Nutrition
N2  - The uptake and mobilization of 13(S)-hydroxyoctadecadienoic acid (HODE) was investigated in Syrian hamster embryo (SHE) cells with a normal phenotype (supB+ cells) and that have lost tumour suppression function (supB- cells). Epidermal growth factor (EGF) 10 ng/ml stimulated a time- and dose-dependent incorporation and reacylation of 10\microM 13-HODE. The level of 13-HODE uptake in supB+ SHE cells was twice that of supB- SHE cells. Among classes of phospholipids, radiolabelled 10 µM 13-HODE was esterified predominantly into phosphatidylcholine and this distribution pattern was similar for both SHE cell lines. Pretreatment of cells with 10 µM of the tyrosine kinase inhibitor methyl-2,5-dihydroxycinnamate blocked EGF-stimulated HODE incorporation. Inhibition of tyrosine phosphatase activity with 100 µM sodium orthovanadate potentiated HODE uptake in supB+ but not supB- cells. Moreover, activation of protein kinase C with 20 nM phorbol ester stimulated HODE incorporation in the supB+ line only. It is concluded that the differential effects of EGF on 13-HODE uptake and mobilization in supB+ and supB- cells appear to be related to loss of the tumour suppressor phenotype. EGF-stimulated generation of esterified 13-HODE may be an important biological process in determining the mechanism and site of HODE interaction with the mitogenic signalling pathway.
KW  - cell cultures
KW  - enzymes
KW  - epidermal growth factor
KW  - fibroblasts
KW  - genetics
KW  - inhibitors
KW  - linoleic acid
KW  - metabolism
KW  - metabolites
KW  - mitogens
KW  - mobilization
KW  - neoplasms
KW  - phenotypes
KW  - phosphatidylcholines
KW  - phospholipids
KW  - protein kinase
KW  - uptake
KW  - hamsters
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - lecithins
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403024&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat.
AU  - Purdon, D.
AU  - Arai, T.
AU  - Rapoport, S.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1997///
VL  - 38
IS  - 3
SP  - 526
EP  - 530
SN  - 0022-2275
AD  - Purdon, D.: Laboratory of Neurosciences, National Institute of Aging, National Institutes of Health, Bldg. 10, Room 6C-103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971405111.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 57-88-5, 57-10-3.  Subject Subsets: Human Nutrition
N2  - Awake adult rats were given a solution of [9,10-³H]palmitate ([³H]PAM) by gavage. The appearance of radiolabel in plasma lipid fractions was monitored by thin-layer chromatography at fixed intervals thereafter. At 2 h, the rats were killed by microwave irradiation and radioactivity in whole brain and individual brain phospholipids was determined. In plasma, esterified [³H]PAM was mainly associated with triglyceride, phospholipid and cholesterol ester. Radioactivity appeared to a larger extent in triglyceride than in unesterified fatty acid, suggesting that unesterified [³H]PAM in plasma was largely due to release from esterified [³H]PAM by lipoprotein lipase hydrolysis. Brain radioactivity could be accounted for entirely by incorporation of unesterified plasma [³H]PAM. Esterified [³H]PAM in chylomicrons or lipoproteins was calculated to make no measurable contribution using a published value for the incorporation coefficient of [³H]PAM into brain in the evaluation. The results suggest that ingested palmitic acid (PAM) in adult rats enters blood as esterified triglyceride within chylomicrons and lipoproteins and, in part, eventually is converted to circulating unesterified PAM. It is the circulating unesterified PAM that is incorporated into brain from blood, whereas esterified PAM within plasma chylomicrons and lipoproteins makes no measurable direct contribution.
KW  - blood lipids
KW  - brain
KW  - cholesterol
KW  - chylomicron lipids
KW  - esterification
KW  - esters
KW  - fatty acids
KW  - incorporation
KW  - lipids
KW  - lipoproteins
KW  - palmitic acid
KW  - phospholipids
KW  - plasma
KW  - triacylglycerols
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - chylomicrons
KW  - hexadecanoic acid
KW  - lipins
KW  - triglycerides
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405111&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A new route to N-substituted 11-azaartemisinins.
AU  - Mekonnen, B.
AU  - Ziffer, H.
JO  - Tetrahedron Letters
JF  - Tetrahedron Letters
Y1  - 1997///
VL  - 38
IS  - 5
SP  - 731
EP  - 734
SN  - 0040-4039
AD  - Mekonnen, B.: NIMH, Laboratory of Clinical Science, National Institutes of Health, Bethesda, MD 20892-0510, USA.
N1  - Accession Number: 19980807472.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Registry Number: 63968-64-9.  Subject Subsets: Botanical Pesticides; Protozoology
N2  - A series of N-substituted 11-azaartemisinins were prepared in high yield by Michael additions to the amide nitrogen of 11-azaartemisinin. The presence of substituents on the unsaturated system of the Michael acceptor markedly decreased the yield of the reaction.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - artemisinin
KW  - chemistry
KW  - human diseases
KW  - malaria
KW  - parasites
KW  - sesquiterpenoid lactones
KW  - synthesis
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - artemisinine
KW  - azaartemisinins
KW  - qinghaosu
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807472&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Overexpression of human lecithin:cholesterol acyltransferase in cholesterol-fed rabbits: LDL metabolism and HDL metabolism are affected in a gene dose-dependent manner.
AU  - Brousseau, M. E.
AU  - Santamarina-Fojo, S.
AU  - Vaisman, B. L.
AU  - Applebaum-Bowden, D.
AU  - Bérard, A. M.
AU  - Talley, G. D.
AU  - Brewer, H. B., Jr.
AU  - Hoeg, J. M.
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1997///
VL  - 38
IS  - 12
SP  - 2537
EP  - 2547
SN  - 0022-2275
AD  - Brousseau, M. E.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981404321.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 57-88-5, 9031-14-5.  Subject Subsets: Human Nutrition
N2  - 131I-labelled HDL apolipoprotein (apo)A-I and 125I-labelled LDL kinetics were assessed in age- and sex-matched groups of rabbits with high (HE), low (LE) or no human lecithin:cholesterol acyltransferase [phosphatidylcholine-sterol acyltransferase] (LCAT) expression after 6 weeks on a 0.3% cholesterol diet. In HE, the mean total cholesterol concentration (mg/100 ml) on this diet (230±50) was not significantly different from that of LE (313±46) or controls (332±52) due to the increased level of HDL-cholesterol (C) observed in HE (127±19), as compared with LE (100±33) and controls (31±4). In contrast, the mean nonHDL-C concentration for HE (103±33) was much lower than that for LE (213±39) or controls (301±55). Fast protein liquid chromatography analysis of plasma confirmed that HDL was the predominant lipoprotein class in HE on the cholesterol diet, whereas cholesteryl ester-rich, apoB-containing lipoproteins characterized the plasma of LE and, most notably, of controls. In vivo kinetic experiments demonstrated that the differences in HDL levels noted between the 3 groups were attributable to distinctive rates of apoA-I catabolism, with the mean fractional catabolic rate (FCR)/day of apoA-I slowest in HE (0.282±0.03), followed by LE (0.340±0.01) and controls (0.496±0.04). A similar, but opposite, pattern was observed for nonHDL-C levels and LDL metabolism (h-1), such that HE had the lowest nonHDL-C levels with the fastest rate of clearance (0.131±0.027), followed by LE (0.057±0.009) and controls (0.031±0.001). Strong correlations were noted between LCAT activity and apoA-I (r = -0.868, P&lt;0.01) and LDL (r = 0.670) FCR, indicating that LCAT activity played a major role in the mediation of lipoprotein metabolism. It is concluded that these data are the first to show that LCAT overexpression can regulate both LDL and HDL metabolism in cholesterol-fed rabbits and provide a potential explanation for the prevention of diet-induced atherosclerosis previously observed.
KW  - apolipoproteins
KW  - atherosclerosis
KW  - blood
KW  - cholesterol
KW  - gene expression
KW  - high density lipoprotein
KW  - intake
KW  - kinetics
KW  - lipoproteins
KW  - low density lipoprotein
KW  - metabolism
KW  - phosphatidylcholine-sterol acyltransferase
KW  - rabbits
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arteriosclerosis
KW  - lecithin-cholesterol acyltransferase
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404321&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spinal intramedullary cysticercosis.
AU  - Mohanty, A.
AU  - Venkatrama, S. K.
AU  - Das, S.
AU  - Shankar, B.
AU  - Rao, B. R.
AU  - Vasudev, M. K.
JO  - Neurosurgery
JF  - Neurosurgery
Y1  - 1997///
VL  - 40
IS  - 1
SP  - 82
EP  - 87
SN  - 0148-396X
AD  - Mohanty, A.: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
N1  - Accession Number: 19970803222.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Helminthology
N2  - Eight patients who were surgically treated for spinal intramedullary cysticercosis between 1982 and 1991 in Bangalore, Karnataka, India, were retrospectively reviewed, and the final outcomes were assessed. In 6 patients, the cysticercosis involved the thoracic cord, whereas in the other 2, the cysticercosis was cervical in location. Only one patient had multiple soft tissue calcifications, as revealed by plain radiography. Myelography indicated an intramedullary lesion in each of 7 patients; 2 of the 7 patients had partial myelographic block, suggesting the segmental nature of the lesion. Cerebrospinal fluid studies were non-contributory. One patient had 3 cysts, whereas the other 7 had 1 cyst each. Four patients had adjacent soft purulent materials, which were revealed by histopathological examination to be granulation tissue. The neurological statuses of 7 patients improved after surgery. Six patients were followed up for a mean of 30.6 months (3 months to 5 years). Three resumed their previous occupations, 2 others were able to manage their daily activities, and one required only minimal assistance for daily activities.
KW  - case reports
KW  - cysticercosis
KW  - helminths
KW  - human diseases
KW  - metacestodes
KW  - parasites
KW  - spinal cord
KW  - India
KW  - Karnataka
KW  - man
KW  - Taenia solium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - Mysore
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803222&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 integrase pharmacophore: discovery of inhibitors through three dimensional database searching.
AU  - Nicklaus, M. C.
AU  - Neamati, N.
AU  - Hong HuiXiao
AU  - Mazumder, A.
AU  - Sunder, S.
AU  - Chen, J.
AU  - Milne, G. W. A.
AU  - Pommier, Y.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 6
SP  - 920
EP  - 929
SN  - 0022-2623
AD  - Nicklaus, M. C.: Laboratories of Medicinal Chemistry and Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972003704.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
N2  - Starting from a known inhibitor of HIV-1 integrase (IN), caffeic acid phenethyl ester (CAPE), putative three-point pharmacophore for binding of inhibitors to IN was derived. This pharmacophore was used to search the National Cancer Institute three-dimensional (3D) structural database. Out of the open, nonproprietary part of this database, comprising approximately 200,000 compounds, 267 structures were found to match the pharmacophore in at least one conformation, and 60 of these were tested in an in vitro assay against HIV-1 IN. Out of these, 19 were found to inhibit both the 3' processing and strand transfer of IN at micromolar concentrations. In order to test the validity of this pharmacophore, a small 3D database of 152 published IN inhibitors was built. A search in this database yielded a statistically significant correlation of the presence of this pharmacophore and the potency of the compounds. An automated pharmacophore identification procedure performed on this set of compounds provided additional support for the importance of this pharmacophore for binding of inhibitors to IN and hinted at a possible second pharmacophore. The role of aromatic moieties in the binding of ligands to HIV-1 IN through interactions with divalent metal cations, which are known to be necessary for activity of the enzyme, was explored in ab initio calculations.
KW  - antiviral agents
KW  - antiviral properties
KW  - aromatic compounds
KW  - assays
KW  - databases
KW  - in vitro
KW  - inhibitors
KW  - interactions
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - aromatics
KW  - data banks
KW  - human immunodeficiency virus type 1
KW  - integrase inhibitors
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003704&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
AU  - Hong HuiXiao
AU  - Neamati, N.
AU  - Wang ShaoMeng
AU  - Nicklaus, M. C.
AU  - Mazumder, A.
AU  - Zhao, H.
AU  - Burke, T. R., Jr.
AU  - Pommier, Y.
AU  - Milne, G. W. A.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 6
SP  - 930
EP  - 936
SN  - 0022-2623
AD  - Hong HuiXiao: Laboratories of Medicinal Chemistry and Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972003705.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
N2  - Based upon a class of known HIV-1 integrase inhibitors, several pharmacophore models were proposed from molecular modelling studies and validated using a 3D database of 152 compounds for which integrase assay data are known. Using the most probable pharmacophore model as the query, the NC1 3D database of 206,876 compounds was searched, and 340 compounds that contain the pharmacophore query were identified. 29 of these compounds were selected and tested in the HIV-1 integrase assay. This led to the discovery of 10 novel, structurally diverse HIV-1 integrase inhibitors, four of which have an IC50 value &lt;30 µM and are promising lead compounds for further HIV-1 integrase inhibitor development.
KW  - antiviral agents
KW  - antiviral properties
KW  - databases
KW  - inhibitors
KW  - models
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - data banks
KW  - human immunodeficiency virus type 1
KW  - integrase inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003705&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hydrazide-containing inhibitors of HIV-1 integrase.
AU  - Zhao He
AU  - Neamati, N.
AU  - Sunder, S.
AU  - Hong HuiXiao
AU  - Wang ShaoMeng
AU  - Milne, G. W. A.
AU  - Pommier, Y.
AU  - Burke, T. R., Jr.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 6
SP  - 937
EP  - 941
SN  - 0022-2623
AD  - Zhao He: Laboratories of Medicinal Chemistry and Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972003706.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 120-80-9. 
N2  - A large number of inhibitors of HIV integrase discovered to date contain the o-bis-hydroxy catechol structure. In an effort to discover structural leads for the development of new HIV integrase inhibitors which do not rely on this potentially cytotoxic catechol substructure, NSC 310217 was identified using a three-point pharmacophore search based on its assigned structure N-(2-hydroxybenzoyl)-N-(2-hydroxy-3-phenoxypropyl)hydrazine. When a sample of NSC 310217 was obtained from the NCI repository, it was shown to exhibit potent inhibition of HIV-1 integrase (3′-processing IC50=0.6 µg/ml). Work reported herein demonstrates that NSC 320217, rather than containing N-(2-hydroxybenzoyl)-N-(2-hydroxy-3-phenoxypropyl)hydrazine, which has no inhibitory potency against HIV-1 integrase, is comprised of roughly a 1:1 mixture of N-(2-hydroxybenzoyl)-N′-(2-hydroxy-3-phenoxypropyl)hydrazine and N,N′-bis-salicylhydrazine, with all inhibitory potency residing with the latter compound (IC50 = 0.7 µM for strand transfer).
KW  - antiviral agents
KW  - antiviral properties
KW  - cytotoxicity
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - inhibitors
KW  - pyrocatechol
KW  - structure
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - anti-viral properties
KW  - catechol
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - integrase inhibitors
KW  - pyrocatechin
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003706&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AU  - Neamati, N.
AU  - Hong HuiXiao
AU  - Mazumder, A.
AU  - Wang ShaoMeng
AU  - Sunder, S.
AU  - Nicklaus, M. C.
AU  - Milne, G. W. A.
AU  - Proksa, B.
AU  - Pommier, Y.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 6
SP  - 942
EP  - 951
SN  - 0022-2623
AD  - Neamati, N.: Laboratories of Molecular Pharmacology and Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972003707.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
N2  - 17 lichen acids comprising depsides, depsidones and their synthetic derivatives were examined for their inhibitory activity against HIV-1 integrase, and 2 pharmacophores associated with inhibition of this enzyme were identified. A search of the NCI 3D database of approx. 200,000 structures yielded some 800 compounds which contain one or the other pharmacophore. 42 of these compounds were assayed for HIV-1 integrase inhibition, and of these 27 had inhibitory IC50 values of &lt;100 µM; 15 were below 50 µM. Several of these compounds were also examined for their activity against HIV-1 integrase and mammalian topoisomerase.
KW  - antiviral agents
KW  - antiviral properties
KW  - databases
KW  - derivatives
KW  - inhibition
KW  - inhibitors
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - data banks
KW  - human immunodeficiency virus type 1
KW  - integrase inhibitors
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003707&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Arylamide inhibitors of HIV-1 integrase.
AU  - Zhao, H.
AU  - Neamati, N.
AU  - Mazumder, A.
AU  - Sunder, S.
AU  - Pommier, Y.
AU  - Burke, T. R., Jr.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 8
SP  - 1186
EP  - 1194
SN  - 0022-2623
AD  - Zhao, H.: Laboratory of Medicinal Chemistry, Bldg 37, Rm 5C06, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004644.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 9007-49-2. 
KW  - antiviral agents
KW  - DNA
KW  - enzymes
KW  - HIV-1 infections
KW  - human diseases
KW  - inhibitors
KW  - integration
KW  - microbiology
KW  - structure
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - arylamides
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004644&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
AU  - Mazumder, A.
AU  - Neamati, N.
AU  - Sunder, S.
AU  - Pertz, H.
AU  - Eich, E.
AU  - Pommier, Y.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 19
SP  - 3057
EP  - 3063
SN  - 0022-2623
AD  - Mazumder, A.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bldg 37, Rm 5C25, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972009823.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 458-37-7, 9007-49-2. 
N2  - The present study explores the mechanism of action of curcumin (diferuloylmethane) in detail using natural and synthetic analogues. Equivalent potencies of curcumin analogues are demonstrated against wild-type integrase and an integrase protein containing a mutation in the DNA binding domain. The synergistic effects obtained using a curcumin analogue in combination with another integrase inhibitor, NSC 158393, are reflective of drug binding sites which may not overlap. Binding of these analogues to the enzyme and these enzyme-inhibitor complexes to viral DNA was examined. These studies can provide mechanistic and structural information which may guide the future design of integrase inhibitors. Editorial comment:Integrase is one of the three critical enzymes in the HIV replication cycle (reverse transcriptase and protease are the other two) that can be targeted for therapeutic interventions. It has remained the most elusive of them. Studies like this one help us understand better how this enzyme works and show inhibition by curcumin (a natural colourant of some tropical medicinal plants). This knowledge should help in the design of new integrase inhibitor drugs that could be potentially useful in the future.
KW  - antiviral agents
KW  - antiviral properties
KW  - binding
KW  - curcumin
KW  - DNA
KW  - drugs
KW  - enzymes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - information
KW  - inhibition
KW  - mutations
KW  - proteinases
KW  - replication
KW  - structure
KW  - treatment
KW  - Curcuma aromatica
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Curcuma
KW  - Zingiberaceae
KW  - Zingiberales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - anti-viral properties
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - integrase inhibitors
KW  - medicines
KW  - pharmaceuticals
KW  - proteases
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009823&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-aryl-substituted benzimidazoles.
AU  - Roth, T.
AU  - Morningstar, M. L.
AU  - Boyer, P. L.
AU  - Hughes, S. H.
AU  - Buckheit, R. W. Jr.
AU  - Michejda, C. J.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1997///
VL  - 40
IS  - 26
SP  - 4199
EP  - 4207
SN  - 0022-2623
AD  - Roth, T.: Molecular Aspects of Drug Design Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA.
N1  - Accession Number: 19982001945.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref.
N2  - The best inhibitor, 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimidazole has an IC50 = 200 nM against HIV-1 wild-type reverse transcriptase in an in vitro enzyme assay. Cytoprotection assays utilizing HIV-infected MT-4 cells revealed that it had strong antiviral activity (EC50 = 440) against wild-type virus while retaining broad activity against many clinically observed HIV-1 strains resistant to nonnucleoside inhibitors.
KW  - antiviral agents
KW  - enzyme inhibitors
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - imidazoles
KW  - in vitro
KW  - inhibitors
KW  - resistance
KW  - reverse transcriptase inhibitors
KW  - strains
KW  - synthesis
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - non-nucleoside reverse transcriptase inhibitors
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001945&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fungaemia caused by Hansenula anomala - an outbreak in a cancer hospital.
AU  - Thuler, L. C. S.
AU  - Faivichenco, S.
AU  - Velasco, E.
AU  - Martins, C. A.
AU  - Nascimento, C. R. G.
AU  - Castilho, I. A. M. A.
JO  - Mycoses
JF  - Mycoses
Y1  - 1997///
VL  - 40
IS  - 5-6
SP  - 193
EP  - 196
SN  - 0933-7407
AD  - Thuler, L. C. S.: Cancer Hospital, National Cancer Institute, CEP 20230-130, Rio de Janeiro, Brazil.
N1  - Accession Number: 19981200468.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology; Tropical Diseases
N2  - An outbreak of 24 cases of fungaemia due to H. anomala is reported from a cancer hospital in Rio de Janeiro, Brazil, during July 1994-April 1996. The median age of the patients was 11 years, of whom 54.2% were female; 91.7% of the Hansenula fungaemia cases occurred in the haematology unit. The most frequent primary disease diagnosis was leukaemia (62.5%) and all of those infected had had a central venous catheter or peripheral venous catheter and had been treated previously with broad-spectrum antibiotics. Numerous other risk factors were observed: previous use of steroids, chemotherapy, radiation therapy and neutropenia. No deaths could be attributed to Hansenula infection.
KW  - blood
KW  - fungaemia
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - leukaemia
KW  - neoplasms
KW  - nosocomial infections
KW  - opportunistic infections
KW  - predisposition
KW  - Brazil
KW  - man
KW  - Pichia anomala
KW  - Saccharomycetaceae
KW  - Hansenula
KW  - Pichiaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Pichia
KW  - blood cancer
KW  - cancers
KW  - fungemia
KW  - fungus
KW  - Hansenula anomala
KW  - hospital infections
KW  - leucaemia
KW  - leukemia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200468&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.
AU  - Neamati, N.
AU  - Mazumder, A.
AU  - Zhao, H.
AU  - Sunder, S.
AU  - Burke, T. R., Jr.
AU  - Schultz, R. J.
AU  - Pommier, Y.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1997///
VL  - 41
IS  - 2
SP  - 385
EP  - 393
SN  - 0066-4804
AD  - Neamati, N.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972002421.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
N2  - The inhibitory effect of a series of sulfones and sulfonamides against HIV integrase (IN) was determined. Among 52 diaryl sulfones tested, 4 were highly potent (50% inhibitory concentration (IC50), 0.8-10 µg/ml), 5 had good potencies (IC50, 11-50 µg/ml), 10 showed moderate potencies (IC50, 51-100 µg/ml) and 33 were inactive (IC50 &gt;100 µg/ml) against IN. All of the active compounds exhibited similar potencies against HIV-2 IN. Sulfa drugs, used extensively in treating Pneumocystis carinii pneumonia, were also examined. Among 19 sulfonamides tested, sulfasalazine (IC50 50 µg/ml) was the most potent. It is concluded that potent inhibitors of IN can be designed based on the results presented in this study.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - antiviral properties
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - inhibitors
KW  - mortality
KW  - sulfonamides
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - AIDS
KW  - anti-viral properties
KW  - death rate
KW  - diarylsulfones
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - integrase inhibitors
KW  - sulphonamides
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002421&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology.
AU  - Humphrey, R. W.
AU  - Ohagen, A.
AU  - Davis, D. A.
AU  - Fukuzawa, T.
AU  - Hayashi, H.
AU  - Höglund, S.
AU  - Mitsuya, H.
AU  - Yarchoan, R.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1997///
VL  - 41
IS  - 5
SP  - 1017
EP  - 1023
SN  - 0066-4804
AD  - Humphrey, R. W.: Correspondence address [Yarchoan, R.]: HIV and AIDS Malignancy Branch of the National Cancer Institute, Bldg 10, Rm. 12N226, National Institutes of Health, Bethesda, MD 20892-1906, USA.
N1  - Accession Number: 19972005244.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 63231-63-0. 
N2  - The processing of gag and gag-pol polyproteins by HIV-1 protease is a crucial step in the formation of infectious HIV-1 virions. This study examined whether particles produced in the presence of inhibitors of HIV-1 protease can subsequently undergo gag polyprotein cleavage with restoration of infectivity following removal of the inhibitors. Viral particles produced during 7 days of culture in the presence of the protease inhibitors KNI-272 (10 µM) and saquinavir (5µM) contained predominantly p55gag polyprotein but little or no p24gag cleavage product. Following resuspension of the particles in medium free of the inhibitor, some gag polyprotein processing was detected in particles produced from the KNI-272-treated cells, but not from the saquinavir-treated cells within the first 3 h. However, the majority of the protein remained as p55gag throughout a 48-h experimental period. The infectivity (50% tissue culture infective dose per ml) of the viral particles from KNI-272-treated cells was 106-fold lower than that of control particles and did not significantly increase over the 48 h after the inhibitor-treated cells nor to a failure of HIV RNA to be packaged in the virions. These particles also failed to express the mature phenotype by electron microscopy. Thus, while some processing of the gag polyprotein can occur in isolated HIV virions, this does not appear to be sufficient to restore infectivity in the majority of particles. This finding suggests that there may be constraints on postbudding polyprotein processing in the production of viable particles. These results should have positive implications regarding the use of protease inhibitors as anti-HIV drugs.
KW  - antiviral agents
KW  - experiments
KW  - formulations
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infectivity
KW  - inhibitors
KW  - phenotypes
KW  - proteinase inhibitors
KW  - proteinases
KW  - RNA
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - protease inhibitors
KW  - proteases
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005244&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In vitro induction of human immunodeficiency virus type 1 variants resistant to 2′-β-fluoro-2′,3′-dideoxyadenosine.
AU  - Tanaka, M.
AU  - Srinivas, R. V.
AU  - Ueno, T.
AU  - Kavlick, M. F.
AU  - Hui, F. K.
AU  - Fridland, A.
AU  - Driscoll, J. S.
AU  - Mitsuya, H.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1997///
VL  - 41
IS  - 6
SP  - 1313
EP  - 1318
SN  - 0066-4804
AD  - Tanaka, M.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972006176.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9068-38-6. 
N2  - 2′-β-Fluoro-2′,3′-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analogue active against a wide spectrum of HIV-1 and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. HIV-1 variants resistant to F-ddA were induced by exposing wild-type HIV-1 (HIV-1LAI) to increasing concentrations of F-ddA in vitro. After 18 passages, the virus was 4-fold less sensitive to F-ddA than HIV-1LAI. Sequence analyses of the passage 18 virus revealed changes in 3 amino acids in the reverse transcriptase (RT)-encoding region of the pol gene: P to S at codon 119 (P119S; present in 3 of 13 and 28 of 28 molecular clones before and after F-ddA exposure, respectively). V179D (0 of 13 and 9 of 28, respectively), and L214F (9 of 13 and 28 of 28, respectively). Drug sensitivity assays using recombinant infectious clones confirmed that P119S was directly responsible for the reduced sensitivity of HIV-1 to F-ddA. Various infectious clones with single or multiple amino acid substitutions conferring viral resistance against nucleoside RT inhibitors, including HIV-1 variants with multi-dideoxynucleoside resistance, were generally sensitive to F-ddA. The moderate level of resistance of HIV-1 to F-ddA, together with the lack of conferment of significant cross-resistance by the F-ddA-associated amino acid substitutions, warrants further investigation of F-ddA as a potential antiviral agent for use in treatment of HIV-1 infection.
KW  - amino acids
KW  - analogues
KW  - antiviral agents
KW  - clinical aspects
KW  - clinical trials
KW  - clones
KW  - drug resistance
KW  - drugs
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - nucleoside analogues
KW  - nucleosides
KW  - resistance
KW  - reverse transcriptase
KW  - strains
KW  - susceptibility
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - analogs
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - medicines
KW  - molecular clones
KW  - nucleoside analogs
KW  - pharmaceuticals
KW  - sensitivity
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection.
AU  - Polis, M. A.
AU  - Piscitelli, S. C.
AU  - Vogel, S.
AU  - Witebsky, F. G.
AU  - Conville, P. S.
AU  - Petty, B.
AU  - Kovacs, J. A.
AU  - Davey, R. T., Jr.
AU  - Walker, R. E.
AU  - Falloon, J.
AU  - Metcalf, J. A.
AU  - Craft, C.
AU  - Lane, H. C.
AU  - Masur, H.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1997///
VL  - 41
IS  - 8
SP  - 1709
EP  - 1714
SN  - 0066-4804
AD  - Polis, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, RM 11C103, Mailstop 1880, Bethesda, MD 20982-1880, USA.
N1  - Accession Number: 19972008302.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 81103-11-9, 30516-87-1. 
N2  - Co-administration of zidovudine (AZT) and clarithromycin at 3 doses (500 mg orally [po] twice daily [bid], 1000 mg po bid, and 2000 mg po bid) reduced the maximum concentration of AZT by 41% (P&lt;0.005) and the area under the concentration-time curve from 0 to 4 hours for AZT by 25% (P&lt;0.05) and increased the time to maximum concentration of AZT by 84% (P&lt; 0.05), compared with AZT administered alone. Mixing studies did not detect the formation of insoluble complexes due to chelation, suggesting that the decrease in AZT concentrations results from some other mechanism. Simultaneous administration of AZT and clarithromycin appears to decrease the levels of AZT in serum, and it may be advisable that these drugs not be given at the same time. Drug interactions should be carefully evaluated in persons with advanced HIV infection who are receiving multiple pharmacological agents.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - blood plasma
KW  - clarithromycin
KW  - concentration
KW  - drug therapy
KW  - drugs
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - pharmacokinetics
KW  - treatment
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - AZT
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - medicines
KW  - pharmaceuticals
KW  - plasma (blood)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008302&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intraspecific variation and phylogenetic relationships in the genus Entamoeba as revealed by riboprinting.
AU  - Clark, C. G.
AU  - Diamond, L. S.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1997///
VL  - 44
IS  - 2
SP  - 142
EP  - 154
SN  - 1066-5234
AD  - Clark, C. G.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19980801418.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Subject Subsets: Protozoology
N2  - Eighty-seven isolates of amoebae assigned to the genus Entamoeba were studied by riboprinting (restriction enzyme polymorphism analysis of polymerase chain reaction-amplified small subunit ribosomal RNA genes). Twenty-four distinct patterns were obtained, most of which corresponded to previously described species. In 3 species (Entamoeba coli, E. gingivalis and E. moshkovskii) intraspecific variation was detected that led to the grouping of isolates into 'ribodemes' (populations of amoebae that shared the same riboprint pattern). Riboprint data were used to estimate genetic distances among and within species for the construction of phylogenetic trees based on parsimony and distance analyses. The trees obtained with the 2 methods were largely congruent. In some cases the estimated distances between species were greater than the upper limit recommended for the fragment comigration method of analysis, indicating unusually deep branches within this genus. However, it appeared that species producing cysts with 8 nuclei, species producing cysts with 1 nucleus and species producing cysts with 4 nuclei form morphologically based groups that are supported by riboprint data. E. gingivalis, which does not encyst, clusters with the third group, indicating secondary loss of this ability.
KW  - amoebae
KW  - genes
KW  - genetic mapping
KW  - genetic polymorphism
KW  - molecular taxonomy
KW  - morphology
KW  - parasites
KW  - phylogeny
KW  - polymerase chain reaction
KW  - restriction endonuclease analysis
KW  - ribosomal RNA
KW  - strains
KW  - Entamoeba
KW  - Entamoeba coli
KW  - Entamoeba gingivalis
KW  - Entamoeba moshkovskii
KW  - protozoa
KW  - Endamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Entamoeba
KW  - cysts
KW  - PCR
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801418&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Influence of diet on mammary cancer in transgenic mice bearing an oncogene expressed in mammary tissue.
AU  - Rao, G. N.
AU  - Ney, E.
AU  - Herbert, R. A.
JO  - Breast Cancer Research and Treatment
JF  - Breast Cancer Research and Treatment
Y1  - 1997///
VL  - 45
IS  - 2
SP  - 149
EP  - 158
SN  - 0167-6806
AD  - Rao, G. N.: Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19981406970.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Human Nutrition
N2  - The transgenic mouse line TG.NK with c-neu, the human breast cancer oncogene homologue of erbB2, was evaluated to determine its suitability for study of intervention strategies to delay/prevent the development of breast cancer. There were no palpable mammary tumour masses up to 22-weeks of age, and almost all mice fed on a purified diet developed palpable mammary tumours by 28-weeks of age. Nonpurified diets decreased the incidence and multiplicity, and delayed the development of mammary tumours as compared to a purified diet. Increasing the fibre content of nonpurified diet decreased the tumour incidence further. There was approximately a 19-week interval between weaning and development of palpable mammary masses to evaluate intervention strategies to delay or prevent the development of mammary cancer in the TG.NK mouse model. Fibre from nonpurified cereal ingredients appears to be highly beneficial in delaying the development of mammary cancer in TG.NK mice, and this observation is in agreement with human epidemiological findings. Therefore, the TG.NK transgenic mouse with oncogene c-neu (erbB2), appears to be a useful animal model for evaluation of dietary intervention strategies.
KW  - animal models
KW  - diet
KW  - fibre
KW  - intake
KW  - mammary gland neoplasms
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fiber
KW  - mammary tumour
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406970&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Meta-analyses of dietary fats and mammary neoplasms in rodent experiments.
AU  - Fay, M. P.
AU  - Freedman, L. S.
A2  - Clarke, R.
JO  - Breast Cancer Research and Treatment
JF  - Breast Cancer Research and Treatment
Y1  - 1997///
VL  - 46
IS  - 2/3
SP  - 215
EP  - 223
SN  - 0167-6806
AD  - Fay, M. P.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda MD, USA.
N1  - Accession Number: 19981405785.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Human Nutrition
N2  - Two meta-analyses of experiments on dietary fat and mammary tumour incidence in rodents are reviewed, emphasizing a meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 PUFA most strongly enhance mammary tumours in rodents and that saturated fats also enhance tumours, although less strongly. The research also shows that energy restriction protects against mammary tumours. It is demonstrated that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.
KW  - animal models
KW  - energy deprivation
KW  - fats
KW  - fatty acids
KW  - intake
KW  - international comparisons
KW  - mammary gland neoplasms
KW  - polyenoic fatty acids
KW  - reviews
KW  - saturated fats
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mammary tumour
KW  - polyunsaturated fatty acids
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981405785&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients.
AU  - Ravi, V.
AU  - Parida, S.
AU  - Desai, A.
AU  - Chandramuki, A.
AU  - Gourie-Devi, M.
AU  - Grau, G. E.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1997///
VL  - 51
IS  - 2
SP  - 132
EP  - 136
SN  - 0146-6615
AD  - Ravi, V.: Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
N1  - Accession Number: 19970504233.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 308079-78-9.  Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2  - To investigate the prognostic role of tumour necrosis factor (TNF) in Japanese encephalitis (JE) virus infection, the authors measured the immunoreactive forms of TNF concentrations in the serum and cerebrospinal fluid (CSF) of 47 laboratory-confirmed cases of JE (in Bangalore, India). It was observed that TNF levels were elevated (&gt;15 pg/ml) in all the 47 serum samples (range 19.4-923.8 pg/ml), while in 46 of 47 CSF samples TNF was elevated (range 10.8-376 pg/ml). The mean (SD) TNF levels in the serum of fatal cases was 234.34 pg/ml (304.40) as compared to the mean of 85.31 pg/ml (SD 153.92) in nonfatal cases. Similar observations were also made with respect to the TNF levels in the CSF; the mean of fatal cases was 69.39 pg/ ml (SD 39.00) in contrast to the mean of 62.41 pg/ml (SD 75.25) of nonfatal cases. The increase in TNF levels did not show any correlation to the duration of illness. The mortality rate increased with increasing concentrations of TNF in the serum and CSF. Correlation of laboratory parameters to final outcome revealed that TNF concentrations above 50 pg/ml in serum correlated significantly (P = 0.05) with a fatal outcome, whilst high levels of JE virus IgM antibodies (&gt;500 units) in the CSF correlated with a nonfatal outcome (P = 0.03). These results suggest that TNF can be used as a possible prognosticator of a fatal outcome in JE virus infection.
KW  - arboviruses
KW  - cerebrospinal fluid
KW  - clinical aspects
KW  - cytokines
KW  - human diseases
KW  - immune response
KW  - Japanese encephalitis
KW  - nervous system diseases
KW  - serum
KW  - tumour necrosis factor
KW  - Asia
KW  - India
KW  - Karnataka
KW  - Japanese encephalitis virus
KW  - man
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - arthropod-borne viruses
KW  - cachectin
KW  - cachexin
KW  - clinical picture
KW  - immunity reactions
KW  - immunological reactions
KW  - Mysore
KW  - neuropathy
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine regulation of schistosome-induced granuloma and fibrosis.
AU  - Wahl, S. M.
AU  - Frazier-Jessen, M.
AU  - Jin, W. W.
AU  - Kopp, J. B.
AU  - Sher, A.
AU  - Cheever, A. W.
JO  - Kidney International
JF  - Kidney International
Y1  - 1997///
VL  - 51
IS  - 5
SP  - 1370
EP  - 1375
SN  - 0085-2538
AD  - Wahl, S. M.: Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4352, USA.
N1  - Accession Number: 19980800387.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 130068-27-8, 207137-56-2, 76057-06-2.  Subject Subsets: Helminthology
N2  - Eggs of Schistosoma mansoni trigger a granulomatous inflammatory reaction; the egg antigens are eliminated slowly and the persistent granulomatous response leads to prolonged matrix synthesis and hepatic fibrosis. In mice, soluble egg antigens (SEA) induced interleukin (IL)-4 synthesis, promoting a dominant T helper type 2 lymphocyte accumulation with the release of additional cytokines (IL-5, IL-10) which suppressed Th1 lymphocyte subset cytokines and mediated the characteristic pathophysiology. Manipulation of the cytokine profile with antagonists or exogenous cytokine delivery altered the course of hepatic inflammation and fibrosis. During the granulomatous response, transforming growth factor (TGF)-β was also produced which may have modulated inflammation and regulated fibrogenesis. In TGF-β1-gene targeted mutant mice that over-expressed TGF-β1 (TGF-β1 transgenics) or in which TGF-β1 had been inactivated (TGF-β1-/-; null mutation) or partially inactivated (TGF-β1+/-; null mutation heterozygotes), the altered production of TGF-β1 impacted on S. mansoni granuloma and hepatic fibrosis. Thus, in addition to the Th1/Th2 cytokine balance, modulation of TGF-β1 may change the outcome of chronic inflammatory fibrotic disease.
KW  - antigens
KW  - cytokines
KW  - experimental infections
KW  - fibrosis
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - immune response
KW  - inflammation
KW  - interleukin 10
KW  - interleukin 4
KW  - interleukin 5
KW  - laboratory animals
KW  - liver
KW  - liver diseases
KW  - mutants
KW  - parasites
KW  - pathogenesis
KW  - pathology
KW  - schistosomiasis
KW  - T lymphocytes
KW  - transforming growth factor
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - antigenicity
KW  - bilharzia
KW  - bilharziasis
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800387&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoic acid as a therapy for emphysema?
AU  - DeLuca, L. M.
AU  - Ross, S. A.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1997///
VL  - 55
IS  - 8
SP  - 307
EP  - 308
SN  - 0029-6643
AD  - DeLuca, L. M.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37, Room 3A-17, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19971410643.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - The beneficial role of retinoic acid in emphysema is discussed.
KW  - respiratory diseases
KW  - retinoic acid
KW  - reviews
KW  - therapy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - lung diseases
KW  - therapeutics
KW  - tretinoin
KW  - vitamin A acid
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410643&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular differences between several species of Strongyloides and comparison of selected isolates of S. stercoralis using a polymerase chain reaction-linked restriction fragment length polymorphism approach.
AU  - Srinivasan Ramachandran
AU  - Gam, A. A.
AU  - Neva, F. A.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1997///
VL  - 56
IS  - 1
SP  - 61
EP  - 65
SN  - 0002-9637
AD  - Srinivasan Ramachandran: Clinical Parasitology Unit, Laboratory of Parasitic Diseases, Building 4, Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970802588.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Helminthology
N2  - The relationships between the parasitic nematodes of medical importance belonging to the genus Strongyloides were studied using a polymerase chain reaction (PCR)-linked restriction fragment length polymorphism approach. Several human and dog isolates of S. stercoralis, a monkey isolate of S. fuelleborni, and S. ratti, a rodent parasite, were used. The molecular analysis was based on amplification of the internal transcribed spacer and the 5′ portion of the 23S-like rRNA gene followed by restriction enzyme digests. The length of the PCR product was specific to each species and varied around 1.5 kilobase pairs. Using 9 restriction enzymes, both interspecific and intraspecific variations were analysed. With 4 restriction enzymes (Taq I, Dde I, Dra I and Mwo I), human isolates of S. stercoralis from different parts of the world showed identical patterns and could be differentiated from the dog isolate of S. stercoralis. Interspecific differences were readily observed with these and other enzymes. In addition to providing new information on the genomic characteristics of Strongyloides parasites, the results suggest that this technique could be useful for diagnostic and epidemiological investigations.
KW  - helminths
KW  - molecular genetics
KW  - molecular taxonomy
KW  - parasites
KW  - polymerase chain reaction
KW  - restriction fragment length polymorphism
KW  - Nematoda
KW  - Rhabditida
KW  - Strongyloides
KW  - Strongyloides fuelleborni
KW  - Strongyloides ratti
KW  - Strongyloides stercoralis
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Strongyloididae
KW  - Rhabditida
KW  - Strongyloides
KW  - biochemical genetics
KW  - nematodes
KW  - parasitic worms
KW  - PCR
KW  - RFLP
KW  - Secernentea
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802588&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of malaria parasite RNA from decade-old Giemsa-stained blood smears and dried mosquitoes.
AU  - Li, J.
AU  - Wirtz, R. A.
AU  - McCutchan, T. F.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1997///
VL  - 57
IS  - 6
SP  - 727
EP  - 731
SN  - 0002-9637
AD  - Li, J.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19980803048.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 63231-63-0.  Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology
N2  - RNA isolated from recently prepared and historically preserved slides containing smears of Plasmodium-infected blood was analysed. It was demonstrated that slides preserved for as long as 20 years could yield RNA that was a suitable template for polymerase chain reaction (PCR) amplification. Mosquitoes that had been stored for a number of years under ambient temperature could also be used as an RNA source. The RNA amplification from slide-derived material was shown to be dependent on the addition of reverse transcriptase, and the resultant products were specific to the developmental stage of the parasite. Amplification of ribosomal RNA with primers conserved for Plasmodium and hybridization with species-specific probes provided a general, unbiased method for species determination. Messenger RNA transcripts from slides also appeared to serve as templates. It is suggested that this procedure may add complementary information to that derived from microscopic examination of Giemsa-stained blood smears including species identification, variant antigen identification and drug resistance status.
KW  - analysis
KW  - blood
KW  - diagnosis
KW  - malaria
KW  - nucleotide sequences
KW  - parasites
KW  - polymerase chain reaction
KW  - ribosomal RNA
KW  - RNA
KW  - smears
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - DNA sequences
KW  - mosquitoes
KW  - PCR
KW  - ribonucleic acid
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803048&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclin A negatively regulates E2F transactivation activity.
AU  - Turley, J. M.
AU  - Ruscetti, F. W.
AU  - Kim SeongJin
AU  - Fu Tao
AU  - Gou, F. V.
AU  - Birchenall-Roberts, M. C.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1997///
VL  - 57
IS  - 13
SP  - 2668
EP  - 2675
SN  - 0008-5472
AD  - Turley, J. M.: Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA.
N1  - Accession Number: 19971410904.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Registry Number: 59-02-9, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - Vitamin E succinate (VES) inhibited the proliferation of the oestrogen receptor-negative human breast cancer cell line, BT-20, in the G1 phase of the cell cycle. Overexpression of E2F-1 blocked the ability of VES to inhibit BT-20 cell growth, suggesting that VES regulation of E2F-1 activity leads to growth arrest of BT-20 cells, VES, although having little effect on E2F-1 steady-state protein concentration, decreased E2F-1 phosphorylation and transactivation activity and increased cyclin A binding to E2F-1. GAL4-E2F-1 deletion mutant studies indicated that cyclin A negatively regulates E2F function. In VES-treated BT-20 cells, the cyclin A protein exhibited reduced kinase activity, which correlated with decreased steady-state concentrations and binding of cyclin-dependent kinase-2 to cyclin A and increased steady-state concentrations and binding of p21cip1 to cyclin A and cyclin-dependent kinase-2. The functional consequence of the negative regulatory effect of VES on E2F-1 function was shown by the ability of VES to inhibit the transcriptional activation of an E2F-1 responsive gene, c-myc. These studies show that VES induces growth inhibition of BT-20 cells through a mechanism that involves cyclin A-negative regulation of E2F-mediated transcription.
KW  - alpha-tocopherol
KW  - antineoplastic agents
KW  - breast cancer
KW  - cell cultures
KW  - cell growth
KW  - gene expression
KW  - inhibition
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - transcription
KW  - vitamin e
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cell elongation
KW  - cytotoxic agents
KW  - DNA transcription
KW  - mammary tumour
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice.
AU  - Hursting, S. D.
AU  - Perkins, S. N.
AU  - Brown, C. C.
AU  - Haines, D. C.
AU  - Phang, J. M.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1997///
VL  - 57
IS  - 14
SP  - 2843
EP  - 2846
SN  - 0008-5472
AD  - Hursting, S. D.: Laboratory of Nutritional and Molecular Regulation, Division of Basic Sciences, National Cancer Institute, NIH, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19971411225.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
N2  - Energy restriction (ER) delays spontaneous carcinogenesis in p53-deficient (p53-/-) mice, suggesting that ER modulates carcinogenesis by p53-independent mechanisms. To further evaluate the role of p53, tumour development was monitored in p53-/- and wild-type (p53+/+) mice fed ad libitum (AL) or an ER regimen (60% of AL energy intake). ER delayed tumour mortality in p53-/- and p53+/+ mice (mean time to death, 169 and 648 days, respectively) relative to AL feeding (104 and 470 days). The estimated age-specific cancer death rate AL:ER ratios were 4.3 for p53-/- mice and 4.4 for p53+/+ mice. Thus, despite the accelerated onset of carcinogenesis in p53-/- mice, the tumour-delaying effect of ER was similar in the two genotypes.
KW  - carcinogenesis
KW  - energy deprivation
KW  - energy intake
KW  - food restriction
KW  - genotypes
KW  - neoplasms
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411225&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review.
AU  - Fay, M. P.
AU  - Freedman, L. S.
AU  - Clifford, C. K.
AU  - Midthune, D. N.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1997///
VL  - 57
IS  - 18
SP  - 3979
EP  - 3988
SN  - 0008-5472
AD  - Fay, M. P.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 344, 6130 Executive Blvd. MSC 7354, Bethesda, Maryland 20892-7354, USA.
N1  - Accession Number: 19981400109.  Publication Type: Journal Article.  Language: English.  Number of References: 136 ref. Subject Subsets: Human Nutrition
N2  - A meta-analysis was performed on data extracted from 97 reports of experiments, involving a total of 12 803 mice or rats, studying the effect on mammary tumour incidence of different types of dietary fatty acids. Fatty acids were categorized into saturated, monounsaturated, n-6 polyunsaturated and n-3 polyunsaturated. The relation between tumour incidence and percentage of total energy from these fatty acids was modelled using conditional logistic regression and allowing for varying effects between experiments, and for each fatty acid the effect of substituting the fatty acid energy for nonfat energy was estimated. The n-6 PUFA had a strong tumour-enhancing effect and saturated fats had a weaker tumour-enhancing effect. The n-3 PUFA had a small protective effect that was not significant. There was no significant effect of monounsaturated fats. The n-6 PUFA had a stronger tumour-enhancing effect at levels under 4% of total energy, but an effect is still present at intake levels greater than 4% of energy. In addition, when the intake of n-6 PUFA was at least 4% of energy, the n-6 PUFA effect remained stronger than the saturated fat effect.
KW  - development
KW  - energy intake
KW  - fats
KW  - fatty acids
KW  - intake
KW  - mammary gland neoplasms
KW  - monoenoic fatty acids
KW  - polyenoic fatty acids
KW  - reviews
KW  - saturated fatty acids
KW  - mice
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mammary tumour
KW  - monounsaturated fatty acids
KW  - polyunsaturated fatty acids
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400109&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.
AU  - Dunn, S. E.
AU  - Kari, F. W.
AU  - French, J.
AU  - Leininger, J. R.
AU  - Travlos, G.
AU  - Wilson, R.
AU  - Barrett, J. C.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1997///
VL  - 57
IS  - 21
SP  - 4667
EP  - 4672
SN  - 0008-5472
AD  - Dunn, S. E.: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19981402345.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 61912-98-9.  Subject Subsets: Human Nutrition
N2  - Insulin-like growth factor I (IGF-I) is lowered during dietary restriction (DR) in man and rats. As IGF-I modulates cell proliferation, apoptosis and tumorigenesis, the mechanisms behind the protective effects of DR may depend on the reduction of this multifaceted growth factor. To examine this hypothesis, IGF-I was restored during DR to ascertain if lowering of IGF-I was central to slowing bladder cancer progression during DR. Heterozygous p53-deficient mice received a bladder carcinogen, p-cresidine, to induce preneoplasia. After confirmation of bladder urothelial preneoplasia, the mice were divided into 3 groups: ad libitum; 20% DR; and 20% DR plus IGF-I (IGF-I/DR). Serum IGF-I was lowered 24% by DR but was completely restored in the IGF-I/DR-treated mice using recombinant IGF-I administered via osmotic minipumps. Although tumour progression was decreased by DR, restoration of IGF-I serum concentrations in DR-treated mice increased the stage of the cancers. Furthermore, IGF-I modulated tumour progression independent of changes in body weight. Rates of apoptosis in the preneoplastic lesions were 10 times higher in DR-treated mice compared with those in IGF/DR- and ad libitum-treated mice. Administration of IGF-I to DR-treated mice also stimulated cell proliferation 6-fold in hyperplastic foci. It was concluded that DR lowered IGF-I concentrations, thereby favouring apoptosis over cell proliferation and ultimately slowing tumour progression.
KW  - apoptosis
KW  - bladder
KW  - carcinogenesis
KW  - energy intake
KW  - food restriction
KW  - insulin-like growth factor
KW  - neoplasms
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - somatomedin C
KW  - urinary bladder
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402345&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Natural products in drug discovery and development.
AU  - Cragg, G. M.
AU  - Newman, D. J.
AU  - Snader, K. M.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1997///
VL  - 60
IS  - 1
SP  - 52
EP  - 60
SN  - 0163-3864
AD  - Cragg, G. M.: Natural Products Branch, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19970303849.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - The importance of natural products in drug discovery and development is evaluated with reference to data on new drugs to combat cancer and infectious diseases approved by either the United States Food and Drug Administration or comparable entities in other countries and reported mainly in the Annual Reports of Medicinal Chemistry during 1984-94, and potential anticancer compounds reported to be in the pre-New Drug Application phase up to the end of 1995. Data is presented in the following classes: (B) biologics (vaccines and monoclonals derived from mammalian sources); (N) derived from an unmodified natural product source; (ND) derived from a natural product source; (S) synthetic source; and (S*) synthetic source, but modelled on a natural product parent. Drugs are listed with disease indication, generic name and references. Some chemical structures are also presented.
KW  - anticancer properties
KW  - biological activity
KW  - chemical structure
KW  - medicinal plants
KW  - medicinal properties
KW  - natural products
KW  - plant composition
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - anti-cancer properties
KW  - bioactivity
KW  - chemical constituents of plants
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - United States of America
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Novel cytotoxic, alkylated hydroquinones from Lannea welwitschii.
AU  - Groweiss, A.
AU  - Cardellina, J. H., II
AU  - Pannell, L. K.
AU  - Uyakul, D.
AU  - Kashman, Y.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1997///
VL  - 60
IS  - 2
SP  - 116
EP  - 121
SN  - 0163-3864
AD  - Groweiss, A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19970304352.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Forestry
N2  - Two novel natural products, lanneaquinol and 2′(R)-hydroxylanneaquinol, were isolated from the organic extract of fruits, leaves, stems and twigs of L. welwitschii (collected from Cameroon in 1987). Their structures were solved by spectroanalytical methods and confirmed by comparison to synthetic models. The absolute configuration of 2′(R)-hydroxylanneaquinol was determined by the modified Mosher method. Both compounds exhibited modest cytotoxicity against the NCI panel of 60 human tumour cell lines. The structures of 2 isomeric 4,5-dihydroxy-5-alkyl-2-cyclohexenones, which appear to be biogenetic precursors of the novel hydroquinones, were also elucidated.
KW  - cell lines
KW  - chemical structure
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - fruits
KW  - leaves
KW  - medicinal plants
KW  - plant composition
KW  - quinones
KW  - stems
KW  - Cameroon
KW  - Anacardiaceae
KW  - Lannea
KW  - man
KW  - Sapindales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Anacardiaceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Lannea
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - chemical constituents of plants
KW  - drug plants
KW  - Lannea welwitschii
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Non-wood Forest Products (KK540) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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TY  - JOUR
T1  - Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.
AU  - McKee, T. C.
AU  - Bokesch, H. R.
AU  - McCormick, J. L.
AU  - Rashid, M. A.
AU  - Spielvogel, D.
AU  - Gustafson, K. R.
AU  - Alavanja, M. M.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1997///
VL  - 60
IS  - 5
SP  - 431
EP  - 438
SN  - 0163-3864
AD  - McKee, T. C.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19970306393.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Agroforestry
N2  - Seven new cytotoxic isomalabaricane triterpenes were isolated from a sponge Stelletta sp. (collected from Australia), 2 anti-HIV [human immunodeficiency virus] pterocarpans and 6 isoflavanoids were isolated from 2 tropical plants in the genus Erythrina (bark of E. glauca collected from Guatemala; roots of E. lysistemon collected from Tanzania), and 3 anti-HIV enniatins were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fibre assay.
KW  - antiviral plants
KW  - antiviral properties
KW  - bark
KW  - characterization
KW  - chemical structure
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - human immunodeficiency viruses
KW  - isoflavonoids
KW  - isolation
KW  - medicinal plants
KW  - medicinal properties
KW  - multipurpose trees
KW  - phenolic compounds
KW  - roots
KW  - trees
KW  - woody plants
KW  - Australia
KW  - Guatemala
KW  - Tanzania
KW  - Alternaria
KW  - Erythrina
KW  - Erythrina fusca
KW  - Fusarium
KW  - Papilionoideae
KW  - plants
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Pleosporaceae
KW  - Pleosporales
KW  - Dothideomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Papilionoideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Erythrina
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - CACM
KW  - Central America
KW  - America
KW  - Developing Countries
KW  - Latin America
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - SADC Countries
KW  - anti-viral properties
KW  - drug plants
KW  - Erythrina glauca
KW  - Erythrina lysistemon
KW  - fungus
KW  - human immunodeficiency virus
KW  - Hyphomycetes
KW  - medicinal herbs
KW  - officinal plants
KW  - Stelletta
KW  - Tanganyika
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-wood Forest Products (KK540) 
KW  - Agroforestry and Multipurpose Trees; Community, Farm and Social Forestry (KK600) 
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TY  - JOUR
T1  - Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
AU  - Hallock, Y. F.
AU  - Manfredi, K. P.
AU  - Dai JinRui
AU  - Cardellina, J. H., II
AU  - Gulakowski, R. J.
AU  - McMahon, J. B.
AU  - Schäffer, M.
AU  - Stahl, M.
AU  - Gulden, K. P.
AU  - Bringmann, G.
AU  - François, G.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1997///
VL  - 60
IS  - 7
SP  - 677
EP  - 683
SN  - 0163-3864
AD  - Hallock, Y. F.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19970308516.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Protozoology
N2  - New monomeric (korupensamine E) and dimeric (michellamines D-F) naphthylisoquinoline alkaloids were isolated from extracts of leaves of the tropical liana A. korupensis (collected from Cameroon). Their structures were determined from spectral data and chemical degradation. Michellamines D-F exhibited in vitro HIV [human immunodeficiency virus]-inhibitory activity comparable to that of michellamine B (EC50 values of 2-6 µM). Korupensamine E exhibited in vitro antimalarial activity (against Plasmodium falciparum) comparable to that of korupensamines A-D (IC50 value of 2 µg/ml).
KW  - alkaloids
KW  - antimalarials
KW  - antiprotozoal agents
KW  - antiprotozoal properties
KW  - antiviral plants
KW  - antiviral properties
KW  - biological activity
KW  - chemical structure
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - isoquinoline alkaloids
KW  - leaves
KW  - medicinal plants
KW  - parasites
KW  - plant composition
KW  - plant extracts
KW  - Cameroon
KW  - Ancistrocladaceae
KW  - Ancistrocladus
KW  - Ancistrocladus korupensis
KW  - plants
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Ancistrocladaceae
KW  - Ancistrocladus
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - anti-protozoal properties
KW  - anti-viral properties
KW  - bioactivity
KW  - chemical constituents of plants
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections.
AU  - Deitsch, K. W.
AU  - Moxon, E. R.
AU  - Wellems, T. E.
JO  - Microbiological and Molecular Biology Reviews
JF  - Microbiological and Molecular Biology Reviews
Y1  - 1997///
VL  - 61
IS  - 3
SP  - 281
EP  - 293
AD  - Deitsch, K. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970806170.  Publication Type: Journal Article.  Language: English.  Number of References: 192 ref. Subject Subsets: Protozoology; Medical & Veterinary Mycology
N2  - This review begins with a description of some biological forms of antigenic variation and their effects on the virulence of Trypanosoma brucei, Plasmodium falciparum, Neisseria meningitidis, N. gonorrhoeae, Haemophilus influenzae, Borrelia spp., and Candida albicans. Common characteristics of hypermutable genetic loci which mediate the high rates of phenotypic variation are explored, and genetic mechanisms responsible for such variations are described and depicted diagrammatically. These include phase variation, gene conversion, point mutation, and genomic rearrangement.
KW  - antigenic variation
KW  - gene conversion
KW  - genes
KW  - immune evasion
KW  - loci
KW  - molecular genetics
KW  - mutations
KW  - parasites
KW  - phenotypic variation
KW  - reviews
KW  - virulence
KW  - Borrelia
KW  - Candida albicans
KW  - Haemophilus influenzae
KW  - Neisseria gonorrhoeae
KW  - Neisseria meningitidis
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Trypanosoma brucei
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Haemophilus
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Neisseria
KW  - Neisseriaceae
KW  - Neisseriales
KW  - Betaproteobacteria
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - antigenic polymorphism
KW  - bacterium
KW  - biochemical genetics
KW  - fungus
KW  - genomic rearrangement
KW  - Hyphomycetes
KW  - Meningococcus
KW  - phase variation
KW  - phenotypic variability
KW  - point mutations
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Activity measures in rhesus monkeys on long-term calorie restriction.
AU  - Weed, J. L.
AU  - Lane, M. A.
AU  - Roth, G. S.
AU  - Speer, D. L.
AU  - Ingram, D. K.
JO  - Physiology & Behavior
JF  - Physiology & Behavior
Y1  - 1997///
VL  - 62
IS  - 1
SP  - 97
EP  - 103
SN  - 0031-9384
AD  - Weed, J. L.: Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute of Aging National Institutes of Health, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Baltimore, MD, USA.
N1  - Accession Number: 19971409826.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Human Nutrition
N2  - Energy restriction (ER), undernutrition without malnutrition, extends the mean and maximal lifespan of several ecologically diverse species. Rodents on ER demonstrate increased activity measured as spontaneous locomotion, wheel running, open field behaviour or movement. Activity measures were recorded from 19 male rhesus monkeys (Macaca mulatta) as controls (C) which were fed on a nutritious diet to approximate ad libitum levels, or as experimentals (E) which were fed 30% less than age- and weight-matched controls. Within each diet group, some monkeys (n=10) began ER at 2.3 years of age (range 2.2-2.4 years, J Group) while another group (n=9) began ER at about 4.6 years of age (range 4-5.25, A group). Beginning about 6 years after initiation of the study, behavioural activity was measured via ultrasonic motion detectors and recorded on videotape. Diurnal and circadian activity was clearly discernible. Peaks in activity were associated with mealtime and colony husbandry. Compared to Group A, Group J monkeys exhibited higher overall activity as measured by sensors, and also significantly more circling. Compared to AC monkeys, group AE monkeys demonstrated higher rates of gross motor behaviour, pacing, stereotypies and grooming. The increases in motor activity observed in one group of monkeys were consistent with results obtained from rodent studies of ER and aging. ER did not significantly inhibit or negatively influence the display of behaviour of rhesus monkeys in the laboratory environment.
KW  - activity
KW  - aging
KW  - behaviour
KW  - diet
KW  - energy deprivation
KW  - physical activity
KW  - macaca mulatta
KW  - monkeys
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - behavior
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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ER  - 

TY  - JOUR
T1  - Developmental differences determine larval susceptibility to nitric oxide-mediated killing in a murine model of vaccination against Schistosoma mansoni.
AU  - Ahmed, S. F.
AU  - Oswald, I. P.
AU  - Caspar, P.
AU  - Hieny, S.
AU  - Keefer, L.
AU  - Sher, A.
AU  - James, S. L.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 1
SP  - 219
EP  - 226
SN  - 0019-9567
AD  - Ahmed, S. F.: Parasitology and International Programs Branch, Solar Building, Room 3A-10, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7630, USA.
N1  - Accession Number: 19970801070.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 10102-43-9.  Subject Subsets: Helminthology; Tropical Diseases
N2  - In Schistosoma mansoni infection in animals vaccinated with attenuated parasites, attrition of challenge parasites occurs during migration through the lungs in vivo although parasites recovered from the lungs appear to be relatively resistant to cytotoxic effector mechanisms in vitro. The susceptibilities were compared of different stages of larvae to killing by nitric oxide (NO), which has previously been shown to be involved in the larvicidal function of cytokine-activated cytotoxic effector cells. Lung-stage larvae obtained 1 week after infection of mice with 3000 cercariae were not killed in vitro by NO generated either by a chemical NO donor or by activated cells. In contrast, parasites obtained from the portal system of control mice or from the lungs of vaccinated mice 2.5 weeks following challenge infection were killed by NO. As previously shown for mammalian cell targets, the effects of NO in susceptible larval stages may involve enzymes required for aerobic energy metabolism, since similar cytotoxicity was demonstrated by chemical inhibitors of the citric acid cycle or mitochondrial respiration. Together with previous observations of enhanced Th1 activity and expression of NO synthase in the lungs of vaccinated mice at 2.5 weeks after challenge infection, these observations elucidate the immune mechanism of vaccine-induced resistance to S. mansoni infection and suggest that conversion to a less metabolically active state may allow pathogens to escape the effects of the important effector molecule NO.
KW  - animal models
KW  - digenean larvae
KW  - experimental infections
KW  - helminths
KW  - immunity
KW  - immunization
KW  - in vitro
KW  - laboratory animals
KW  - lungs
KW  - metabolism
KW  - nitric oxide
KW  - parasites
KW  - resistance
KW  - schistosomiasis
KW  - T lymphocytes
KW  - vaccines
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immune sensitization
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Host Resistance and Immunity (HH600) 
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ER  - 

TY  - JOUR
T1  - Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum.
AU  - Zhou Ping
AU  - Sieve, M. C.
AU  - Tewari, R. P.
AU  - Seder, R. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 3
SP  - 936
EP  - 942
SN  - 0019-9567
AD  - Zhou Ping: Lymphokine Regulation Unit, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971200684.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The immunomodulatory effects of interleukin-12 (IL-12) on disseminated histoplasmosis in immunodeficient SCID mice were examined. SCID mice infected with H. capsulatum and treated with IL-12 showed an increase in survival and a reduction in the colony counts of H. capsulatum in internal organs at 14 days after infection. The protective effect of IL-12 was abrogated if animals were also treated with a neutralizing antibody to gamma interferon (IFN-γ). IL-12 treatment also resulted in an increase in mRNA expression and protein production for IFN-γ, tumor necrosis factor alpha (TNF-α) and nitric oxide from spleen cells. When IL-12 was combined with amphotericin B (AmB) treatment, there was a significant increase in survival compared with either modality alone. Moreover, combined treatment resulted in an increase in both IFN-γ and TNF-α production, as well as in a substantial reduction in H. capsulatum burden at 35 and 90 days postinfection. It is concluded that IL-12 modulates the protective immune response to histoplasmosis in SCID mice and that IL-12 in combination with AmB may be useful as a treatment for H. capsulatum in immunodeficient hosts.
KW  - amphotericin B
KW  - antifungal agents
KW  - drug therapy
KW  - experimental infections
KW  - fungicides
KW  - histoplasmosis
KW  - immune response
KW  - immunocompromised hosts
KW  - immunology
KW  - immunosuppression
KW  - immunotherapy
KW  - infections
KW  - interleukins
KW  - opportunistic infections
KW  - predisposition
KW  - synergism
KW  - therapy
KW  - Histoplasma capsulatum
KW  - mice
KW  - Histoplasma
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Ajellomyces
KW  - Ajellomyces capsulatus
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - immunity reactions
KW  - immunological reactions
KW  - synergy
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Pesticides and Drugs (General) (HH400) 
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DB  - lhh
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TY  - JOUR
T1  - A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines.
AU  - Duffy, P. E.
AU  - Kaslow, D. C.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 3
SP  - 1109
EP  - 1113
SN  - 0019-9567
AD  - Duffy, P. E.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA.
N1  - Accession Number: 19980801708.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology
N2  - Alignment of the sequences of the Plasmodium surface proteins Pfs25 (from P. falciparum), Pgs25 and Pgs28 (from P. gallinaceum) revealed areas of nucleotide similarity which were used to produce a polymerase chain reaction probe to find Pfs28, which was sequenced from 7 laboratory strains of P. falciparum. The genes for Pfs25 and Pfs28 were found to be closely linked. Antibodies to Pfs28 blocked infectivity of Plasmodium falciparum in Anopheles freeborni, and when combined with antibodies to Pfs25 provided synergy in blocking transmission. In conclusion, Pfs28 and Pfs25 are immunogenic, have limited antigenic diversity, and are structurally similar and genetically linked on chromosome 10. Pfs28 may prove a useful addition to Pfs25 in an effective transmission-blocking vaccine. The deduced amino acid sequence of Pfs28 has been submitted to GenBank under accession number L25843.
KW  - amino acid sequences
KW  - antigens
KW  - disease transmission
KW  - gene location
KW  - genes
KW  - genetics
KW  - human diseases
KW  - infectivity
KW  - linkage
KW  - malaria
KW  - nucleotide sequences
KW  - parasites
KW  - polymerase chain reaction
KW  - surface antigens
KW  - vaccine development
KW  - Culicidae
KW  - Diptera
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - antigenicity
KW  - DNA sequences
KW  - immunogens
KW  - monosomic analysis
KW  - mosquitoes
KW  - nullisomic analysis
KW  - PCR
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ad libitum food intake in humans after manipulation of glycogen stores.
AU  - Snitker, S.
AU  - Larson, D. E.
AU  - Tataranni, P. A.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 65
IS  - 4
SP  - 941
EP  - 946
SN  - 0002-9165
AD  - Snitker, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 5-41, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19971406297.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9005-79-2.  Subject Subsets: Human Nutrition
N2  - In 8 white men with a mean SD) age of 30±4 years, body weight of 82±20 kg, and percentage body fat of 22±5%, exercise and diets were used to produce high (HG) or low glycogen (LG) stores in a randomized crossover design. After each treatment, a vastus lateralis muscle biopsy was obtained. Subsequent ad libitum food intake was measured with an automated food-selection system during 2 days in a respiratory chamber. Despite a 46±21% difference in muscle glycogen between the two treatments, ad libitum 2-day food intakes (energy, weight or macronutrients) were similar between treatments (HG 23.80±4.67; LG 21.20±6.73 MJ/day). However, energy intake on the second day of ad libitum feeding was negatively correlated with carbohydrate balance on the first day, adjusted for the effect of total energy intake and treatment. Adjusted carbohydrate balance on day 1 only explained 9% of the variance in energy intake on day 2. The 24-h respiratory quotient on the first day after treatment was higher after the HG than after the LG treatment: 0.94±0.04 and 0.88±0.07 (P&lt;0.001). The findings suggest that body glycogen stores play at most a minor role in short-term food intake regulation, and in the short term, imbalances in glycogen stores are corrected by adjustments of macronutrient oxidation rates.
KW  - carbohydrates
KW  - diet
KW  - energy metabolism
KW  - food intake
KW  - glycogen
KW  - men
KW  - skeletal muscle
KW  - stores
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - saccharides
KW  - storage structures
KW  - storehouses
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971406297&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of a new vitamin C-deficient diet in a depletion-repletion clinical trial.
AU  - King, J.
AU  - Wang YaoHui
AU  - Welch, R. W.
AU  - Dhariwal, K. R.
AU  - Conry-Cantilena, C.
AU  - Levine, M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 65
IS  - 5
SP  - 1434
EP  - 1440
SN  - 0002-9165
AD  - King, J.: Department of Nutrition, Diabetes Branch, National Institutes of Health, Bethesda, MD 20892-1372, USA.
N1  - Accession Number: 19971406697.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 50-81-7, 7439-89-6.  Subject Subsets: Human Nutrition
N2  - To examine the recommended dietary allowance (RDA) for ascorbic acid, a unique ascorbic acid-deficient diet was developed using a nutrient database and selective menus. 14 different menus were developed offering &gt;300 items containing ascorbic acid 0-2.4 mg/serving. Seven healthy male volunteers were hospitalized for 116-180 days and daily dietary ascorbic acid was restricted to ≤5.0 mg using the newly developed diet. Mean daily dietary ascorbic acid intake was &lt;3.9 mg for the 7 subjects. With concurrent supplementation, the diet provided ≥85% of the RDA for 17 essential nutrients. Within 3 weeks of admission, the diet induced ascorbic acid deficiency as indicated by plasma concentrations, which decreased from 23±6.9 to 6.9±2.0 µmol/litre. Daily intake of ascorbic acid and 5 other nutrients was estimated by nutrient database analyses. Mean energy, protein and iron were 105-185% of the RDA and total and saturated fat were 32% and 10% of energy, respectively. Weight and nutritionally relevant indexes remained normal. Dietary adherence, calculated by the number of days with ≤5.0 mg ascorbic acid per total study days, was 88-98% per repletion dose. Computer analyses of menu selections permitted individual preferences to be met while restricting ascorbic acid intake to ≤5.0 mg/day. There were no complications from the diet during the depletion and repletion phases. It was concluded that using this diet, ascorbic acid pharmacokinetics for escalating doses could be estimated in healthy volunteers.
KW  - ascorbic acid
KW  - databases
KW  - deficiency
KW  - diet
KW  - energy intake
KW  - iron
KW  - men
KW  - nutrients
KW  - pharmacokinetics
KW  - protein
KW  - recommended dietary allowances
KW  - saturated fats
KW  - trace elements
KW  - vitamin deficiencies
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - data banks
KW  - microelements
KW  - RDA
KW  - recommended dietary intakes
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 gene.
AU  - Chang, Y. C.
AU  - Cherniak, R.
AU  - Kozel, T. R.
AU  - Granger, D. L.
AU  - Morris, L. C.
AU  - Weinhold, L. C.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 5
SP  - 1584
EP  - 1592
SN  - 0019-9567
AD  - Chang, Y. C.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971201195.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - An encapsulated C. neoformans strain, TYCC38-602, was created by transforming C. neoformans strain 602 (an acapsular clinical isolate) with the CAP64 gene which was isolated from a serotype D strain. Serological tests and chemical analysis of the major polysaccharide capsule of TYCC38-602 indicated that strain 602 was originally derived from a serotype A strain. Restoration of the ability to produce a capsule enabled strain 602 to cause fatal infection in mice, whereas the acapsular strain 602 remained avirulent. Capsule-restored yeast cells of strain 602 activated the human complement system and bound C3 fragments in a manner characteristic of encapsulated cryptococci. In addition, the capsule in TYCC38-602 masked the ability of the organism to induce tumour necrosis factor-α and subsequent nitric oxide synthase production in primed macrophage-like cells. The results indicated that the lack of capsule in strain 602 is the reason for its inability to cause fatal infection. The acapsular phenotype accounts for differences in various biological activities of strain 602 compared with encapsulated strains. The results also indicated that the gene product of CAP64 does not contribute to serotype specificity of capsules in C. neoformans.
KW  - cryptococcosis
KW  - experimental infections
KW  - genes
KW  - genetics
KW  - infections
KW  - pathogenicity
KW  - serotypes
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - capsule
KW  - european blastomycosis
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis.
AU  - Siddartha Mahanty
AU  - Manickam Ravichandran
AU  - Uma Raman
AU  - Kunthala Jayaraman
AU  - Kumaraswami, V.
AU  - Nutman, T. B.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 5
SP  - 1742
EP  - 1747
SN  - 0019-9567
AD  - Siddartha Mahanty: Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980800158.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Registry Number: 9008-11-1, 130068-27-8.  Subject Subsets: Helminthology
N2  - The mechanisms by which interleukin-10 (IL-10) regulates antigen-specific hyporesponsiveness in asymptomatic microfilaraemic (MF) individuals were investigated. Peripheral blood mononuclear cells from 11 MF individuals in Madras, India were stimulated in vitro with Brugia malayi antigen (BMA) or mycobacterial purified protein derivative (PPD) in the presence of neutralizing anti-IL-10 or isotype control monoclonal antibodies. As expected, BMA stimulated little or no gamma interferon (IFN-γ) secretion in MF individuals as compared with controls, whereas PPD stimulated IFN-γ in all but one. Neutralization of endogenous BMA-driven IL-10 secretion led to augmentation (1.5- to 10-fold) of IFN-γ in 7 of 9 MF individuals, and did so in a BMA-specific manner (PPD-driven IFN-γ was augmented in only 2 of 8 MF individuals and only 1.5- to 2-fold), indicating that IL-10 downregulates type 1 responses in these individuals. Type 2 responses (IL-5 secretion) were unaffected by the IL-10 blockade. To assess whether IL-12 could reverse the type 1 downregulation observed, the effect of recombinant human IL-12 (rhIL-12) on BMA-driven IL-5 and IFN-γ production was also evaluated. rhIL-12 augmented both BMA- and PPD-driven IFN-γ production 5- to 10-fold in 6 of 9 MF individuals. These data demonstrate that IL-10 downregulates BMA-driven type 1 responses and that IL-12 can overcome downregulation of Th1 responses associated with microfilaraemia, but does so in a non-antigen-specific manner.
KW  - antigens
KW  - filariasis
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - in vitro
KW  - interferon
KW  - interleukin 10
KW  - interleukin 5
KW  - interleukins
KW  - lymphatic filariasis
KW  - microfilariae
KW  - parasites
KW  - India
KW  - Tamil Nadu
KW  - Brugia malayi
KW  - man
KW  - Wuchereria bancrofti
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Wuchereria
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - Madras
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoni.
AU  - Yap, G.
AU  - Cheever, A.
AU  - Caspar, P.
AU  - Jankovic, D.
AU  - Sher, A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 7
SP  - 2583
EP  - 2586
SN  - 0019-9567
AD  - Yap, G.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA.
N1  - Accession Number: 19970803621.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 9008-11-1.  Subject Subsets: Helminthology
N2  - The granulomatous response to schistosome eggs is a CD4 T-cell-dependent, Th2-cytokine-dominated immunopathological response. As infection proceeds to chronicity, both granuloma formation and egg-induced cytokine production become downregulated and previous experiments have implicated CD8 T cells in this process. One mechanism by which CD8 T cells could suppress immunopathology is through the production of the counterregulatory cytokine gamma interferon (IFN-γ). To investigate this hypothesis, hepatic granuloma formation and egg-induced cytokine production were analysed in Schistosoma mansoni-infected gene knockout mice deficient in either CD8 lymphocytes or IFN-γ. It was found that neither immunological component played an essential function in the control of granuloma and cytokine responses during either the acute or chronic stage of infection. Other mechanisms may therefore be more important in the regulation of immunopathology in schistosomiasis.
KW  - acute course
KW  - chronic course
KW  - experimental infections
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - immunopathology
KW  - interferon
KW  - laboratory animals
KW  - parasites
KW  - schistosomiasis
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - severe course
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803621&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of protection induced by immunization with recombinant proteins from different regions of merozoite surface protein 1 of Plasmodium yoelii.
AU  - Tian JingHui
AU  - Sanjai Kumar
AU  - Kaslow, D. C.
AU  - Miller, L. H.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 8
SP  - 3032
EP  - 3036
SN  - 0019-9567
AD  - Tian JingHui: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19980802773.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - To determine which regions of Plasmodium merozoite surface protein 1 (MSP1) can induce protection against malaria, P. yoelii MSP1 was divided into 4 separate regions. Each was expressed in Escherichia coli as a fusion protein with glutathione S-transferase (GST). The N-terminal fragment began after the cleavage site for the signal sequence and ended in the region comparable to the cleavage site for the C terminus of the 82-kDa peptide of P. falciparum. This expressed protein was 30 kDa smaller than the predicted peptide. One peptide from the middle region was produced, and the C terminus consisted of a 42-kDa fragment corresponding to the analogous peptide of P. falciparum and a 19-kDa fragment that extended 37 amino acids in the amino-terminal direction beyond the probable cleavage site. Three mouse strains (CAF1, BALB/c, and A/J) were vaccinated with each of the 4 recombinant proteins of MSP1, and then challenged with potentially lethal doses of P. yoelii. Only 2 of 12 unvaccinated mice survived. Mice vaccinated with the C-terminal 19-kDa protein were highly protected, with 12 of 12 surviving, as were those vaccinated with the 42-kDa protein that contained the 19-kDa fragment (12 of 13 survived). The N-terminally expressed fragment of P. yoelii was not full-length because of proteolytic cleavage in E. coli; the GST-82-kDa partial fragments induced some immunity (9 of 12 survived), but the surviving mice still had high parasitaemias. Vaccination with the peptide from the middle region of MSP1 gave minimal or no protection (6 of 12 survived, with high parasitaemia).
KW  - animal diseases
KW  - experimental infections
KW  - human diseases
KW  - immunization
KW  - laboratory animals
KW  - laboratory mammals
KW  - malaria
KW  - parasites
KW  - recombinant antigens
KW  - recombinant vaccines
KW  - surface antigens
KW  - vaccine development
KW  - mice
KW  - Plasmodium yoelii
KW  - protozoa
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - immune sensitization
KW  - merozoite surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A gene homologous to Saccharomyces cerevisiae SNF1 appears to be essential for the viability of Candida albicans.
AU  - Petter, R.
AU  - Chang, Y. C.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1997///
VL  - 65
IS  - 12
SP  - 4909
EP  - 4917
SN  - 0019-9567
AD  - Petter, R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981200450.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The isolation and characterization of an SNF1 homologue from C. albicans (CaSNF1), which is apparently essential for the viability of this organism, are reported. The putative amino acid sequence of CaSNF1 had 68% identity with that of SNF1 of S. cerevisiae (ScSNF1) and could restore the S. cerevisiaesnf1Δ mutant's ability to utilize sucrose. Disruption of one of the CaSNF1 alleles resulted in morphological changes and decreased growth rates but did not modify the carbon source utilization pattern. Repetitive unsuccessful attempts to generate a snf1/snf1 homozygote by disruption of the second allele, using various vectors and approaches, suggested the lethal nature of this mutation. Integration into the second allele was possible only when a full-length functional SNF1 sequence was reassembled, further supporting this hypothesis and indicating that the indispensability of Snf1p prevented the isolation of snf1/snf1 mutants. The mutant bearing 2 disrupted SNF1 alleles and the SNF1 functional sequence maintained its ability to utilize sucrose and produced stellate colonies with extensive hyphal growth on agar media. It was demonstrated that in a mouse model, the virulences of this mutant and the wild-type strain were similar, suggesting that hyphal growth in vitro is not an indicator for higher virulence.
KW  - candidosis
KW  - experimental infections
KW  - genes
KW  - genetics
KW  - infections
KW  - pathogenicity
KW  - viability
KW  - Candida albicans
KW  - mice
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - candidiasis
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200450&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Randomized trials of sodium reduction: an overview.
AU  - Cutler, J. A.
AU  - Follmann, D.
AU  - Allender, P. S.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 65
IS  - 2SUP
SP  - 643S
EP  - 651S
SN  - 0002-9165
AD  - Cutler, J. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971403449.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 50 + 1 ref. Registry Number: 7440-23-5.  Subject Subsets: Human Nutrition
N2  - This article reviews the evidence as to whether dietary sodium intake should be decreased to lower the risk of cardiovascular disease. More specifically the relationship between change in sodium intake and change in diastolic and systolic blood pressure is examined. Also briefly discussed is whether intake of dietary sodium can be decreased.
KW  - adults
KW  - blood pressure
KW  - cardiovascular diseases
KW  - clinical trials
KW  - hypertension
KW  - intake
KW  - minerals
KW  - reduction
KW  - restricted feeding
KW  - reviews
KW  - salt
KW  - sodium
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Dietary sodium and health
KW  - high blood pressure
KW  - metaanalysis
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403449&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Register of dietary assessment calibration-validation studies: a status report.
AU  - Thompson, F. E.
AU  - Moler, J. E.
AU  - Freedman, L. S.
AU  - Clifford, C. K.
AU  - Stables, G. J.
AU  - Willett, W. C.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 65
IS  - 4 Supp
SP  - 1142S
EP  - 1147S
SN  - 0002-9165
AD  - Thompson, F. E.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 313, 6130 Executive Boulevard, MSC 7344, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19971405918.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 52 ref. Subject Subsets: Human Nutrition
KW  - assessment
KW  - calibration
KW  - diet study techniques
KW  - dietary surveys
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - registers
KW  - Second international conference on dietary assessment methods
KW  - Diet Studies (VV110) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405918&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comments on "adjustments for total energy intake in epidemiologic studies".
AU  - Freedman, L. S.
AU  - Kipnis, V.
AU  - Brown, C. C.
AU  - Schatzkin, A.
AU  - Wacholder, S.
AU  - Hartman, A. M.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 65
IS  - 4 Supp
SP  - 1229S
EP  - 1231S
SN  - 0002-9165
AD  - Freedman, L. S.: Biometry and Cancer Prevention Studies Branches, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7354, USA.
N1  - Accession Number: 19971405967.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 7 ref. Subject Subsets: Human Nutrition
KW  - diet study techniques
KW  - energy
KW  - energy intake
KW  - epidemiology
KW  - methodology
KW  - nutrition
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - methods
KW  - Second international conference on dietary assessment methods
KW  - Diet Studies (VV110) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405967&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterizing food intake patterns of American adults.
AU  - Krebs-Smith, S. M.
AU  - Cleveland, L. E.
AU  - Ballard-Barbash, R.
AU  - Cook, D. A.
AU  - Kahle, L. L.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 65
IS  - 4 Supp
SP  - 1264S
EP  - 1268S
SN  - 0002-9165
AD  - Krebs-Smith, S. M.: National Cancer Institute, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19971405924.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
KW  - adults
KW  - diet study techniques
KW  - food intake
KW  - fruit
KW  - patterns
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Second international conference on dietary assessment methods
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405924&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of supplemental β-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
AU  - Albanes, D.
AU  - Virtamo, J.
AU  - Taylor, P. R.
AU  - Rautalahti, M.
AU  - Pietinen, P.
AU  - Heinonen, O. P.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 66
IS  - 2
SP  - 366
EP  - 372
SN  - 0002-9165
AD  - Albanes, D.: National Cancer Institute, Executive Plaza North-Suite 211, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971410949.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 59-02-9, 7235-40-7, 502-65-8, 127-40-2, 144-68-3.  Subject Subsets: Human Nutrition
N2  - It was determined whether serum carotenoid or retinol concentrations were altered by β-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use. Participants in this substudy were 491 men aged 58-76 years from the metropolitan Helsinki study centre (237 receiving supplemental β-carotene (20 mg/day) and 254 not receiving such supplementation). Dietary carotenoids, retinol, and alcohol, and serum β-carotene, α-tocopherol, retinol, and cholesterol were assessed at baseline. After an average of 6.7 years of supplementation, serum was collected and carotenoid, retinol and α-tocopherol concentrations were estimated by HPLC. Serum carotenoid fractions were highly correlated with each other (P≤0.0001). Compared with the unsupplemented group, the β-carotene group had higher serum concentrations of β-carotene (1483%), α-carotene (145%) and β-cryptoxanthin (67%) (P≤0.0001). Retinol concentrations were 6% higher (P=0.03) and lutein was 11% lower (P=0.02) in the supplemented group. Serum lycopene, zeaxanthin and α-tocopherol did not differ according to β-carotene-supplementation status. Although these β-carotene-group differences were not significantly altered by amount of alcohol consumption, higher consumption (&gt;12.9 g/day, median) was related to lower (10-38%) concentrations of carotenoids, particularly β-carotene, α-carotene and β-cryptoxanthin, in the supplemented and unsupplemented groups. Smoking status did not significantly influence the supplementation-related differences in serum carotenoid and retinol values but concentrations of carotenoids were generally highest in participants who quit smoking while in the study and lowest in current smokers of ≥20 cigarettes/day. This study showed that serum concentrations of non-β-carotene carotenoids are altered by long-term β-carotene supplementation and confirms the adverse effects of alcohol and cigarette smoking on serum carotenoids.
KW  - alcohol intake
KW  - alcoholic beverages
KW  - alpha-tocopherol
KW  - beta-carotene
KW  - blood
KW  - carotenoids
KW  - lycopene
KW  - neoplasms
KW  - supplements
KW  - tobacco smoking
KW  - vitamins
KW  - xanthophyll
KW  - zeaxanthin
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - alcohol consumption
KW  - cancers
KW  - lutein
KW  - tetraterpenoids
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Carrying the burden of cardiovascular risk in old age: associations of weight and weight change with prevalent cardiovascular disease, risk factors, and health status in the Cardiovascular Health Study.
AU  - Harris, T. B.
AU  - Savage, B. J.
AU  - Tell, G. S.
AU  - Haan, M.
AU  - Kumanyika, S.
AU  - Lynch, J. C.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 66
IS  - 4
SP  - 837
EP  - 844
SN  - 0002-9165
AD  - Harris, T. B.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Gateway Building, Room 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892-9205, USA.
N1  - Accession Number: 19981400087.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
N2  - Measured weight in old age, reported weight at 50 years old and weight change from 50 years old to old age were examined in association with prevalent cardiovascular disease (CVD), CVD risk factors and health status in 4954 men and women (≥ 65 years old) who were enrolled in the Cardiovascular Health Study (CHS). Heavier weight (i.e., generally weight in the fourth quartile for the cohort) at 50 years old was more closely associated with prevalent CVD than was current weight, with these associations stronger in women than in men. Heavier current weight and heavier weight at 50 years old were associated with cardiovascular risk factors, including higher blood pressure, lower HDL cholesterol and higher fasting insulin. Heavier weight at both time points was related to mobility problems in men and women and to lower current physical activity levels; among women, strong associations were also seen with lower education and current income. Remaining within 10% of reported weight at 50 years old was associated with better health status as measured by reported health, mobility difficulty, number of medications and prevalent CVD in men. Paradoxically, most cardiovascular risk factors were lowest for weight losers despite an association of weight loss with poorer health. It was concluded that, in this cohort of people aged ≥65 years, heavier weight was associated with CVD and CVD risk factors, suggesting that prevention of overweight may prove beneficial in improving cardiovascular risk in older persons. Weight stability from 50 years old to old age was associated with better health status than was weight gain or loss.
KW  - age
KW  - body weight
KW  - cardiovascular diseases
KW  - health
KW  - men
KW  - obesity
KW  - old age
KW  - risk factors
KW  - sex differences
KW  - weight reduction
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Consistency between US dietary fat intake and serum total cholesterol concentrations: the National Health and Nutrition Examination Surveys.
AU  - Ernst, N. D.
AU  - Sempos, C. T.
AU  - Briefel, R. R.
AU  - Clark, M. B.
A2  - Rivlin, R. S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1997///
VL  - 66
IS  - 4S
SP  - 965S
EP  - 972S
SN  - 0002-9165
AD  - Ernst, N. D.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19971412979.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 16 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Between the early 1970s and early 1990s there were 3 National Health and Nutrition Examination Surveys (NHANES) in the USA: NHANES I, 1971-1974; NHANES II, 1976-1980; and NHANES III, phase 1, 1988-1991. During the 18 years between the mid-point of NHANES I (1972) and the mid-point of phase 1 of NHANES III (1990), the age-adjusted mean percentage of energy from fat declined from 36.4 to 34.1% for adults aged 20-74 years. Trend data are shown in the paper for dietary fat and cholesterol as well as for serum cholesterol from NHANES I (1971-1975) to NHANES III (1988-1991) by age, sex and race-ethnicity. The results document a decline in dietary fat, saturated fat, dietary cholesterol and serum cholesterol. The observed changes reflect those that are predicted by the classic Keys and Hegsted formulas. Changes in reported intake are matched by similar shifts in the food supply for sources of these nutrients. These changes suggest that the Healthy People 2000 goal in the USA of reducing the mean serum cholesterol concentration of US adults to\less or equal\200 mg/100 ml (5.17 mmol/litre) is attainable.
KW  - adults
KW  - age differences
KW  - blood
KW  - cholesterol
KW  - diet studies
KW  - energy intake
KW  - ethnic groups
KW  - fat consumption
KW  - nutrition surveys
KW  - saturated fats
KW  - sex differences
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fats and oil consumption in health and disease
KW  - nutritional surveys
KW  - United States of America
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A comparison of the incidence of severe malaria in Malian children with normal and C-trait hemoglobin profiles.
AU  - Guinet, F.
AU  - Diallo, D. A.
AU  - Minta, D.
AU  - Dicko, A.
AU  - Sissoko, M. S.
AU  - Keita, M. M.
AU  - Wellems, T. E.
AU  - Doumbo, O.
JO  - Acta Tropica
JF  - Acta Tropica
Y1  - 1997///
VL  - 68
IS  - 2
SP  - 175
EP  - 182
SN  - 0001-706X
AD  - Guinet, F.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20 892-0425, USA.
N1  - Accession Number: 19970805572.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology; Tropical Diseases
N2  - A survey of the haemoglobin profiles among children admitted to the Gabriel Touré Hospital in Bamako, Mali, with symptomatic and severe malaria was carried out between August and December 1994. All the children were aged between 6 months and 9 years and identification of Plasmodium falciparum was by Giemsa-stained thick blood films and blood smears. Electrophoresis was used to analyse the haemoglobin types of 169 children; children with AC (heterozygous state for HbA and HbC) and AA (homozygous state for HbA) profiles presented with severe malaria at comparable rates (99 of 149 cases of severe malaria in children with AA profiles; 11 of 16 cases of severe malaria in children with AC and SC profiles). Two children, one of whom presented with cerebral malaria, were found to have SC (heterozygous state for HbS and HbC) profiles. No CC (homozygous for HbC) profiles were detected in the study cohort.
KW  - blood
KW  - cerebral malaria
KW  - children
KW  - haemoglobin
KW  - haemoglobinopathies
KW  - human diseases
KW  - incidence
KW  - malaria
KW  - parasites
KW  - Mali
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - ACP Countries
KW  - Francophone Africa
KW  - Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - haemoglobin C
KW  - hemoglobin
KW  - hemoglobinopathies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference.
AU  - Ward, M. H.
AU  - Sinha, R.
AU  - Heineman, E. F.
AU  - Rothman, N.
AU  - Markin, R.
AU  - Weisenburger, D. D.
AU  - Correa, P.
AU  - Zahm, S. H.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1997///
VL  - 71
IS  - 1
SP  - 14
EP  - 19
SN  - 0020-7136
AD  - Ward, M. H.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981403739.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Human Nutrition
N2  - Telephone interviews were conducted with white men and women diagnosed with adenocarcinoma of the stomach (n=176) and oesophagus (n=143) between July 1988 and June 1993 and 502 controls in 66 counties of eastern Nebraska, USA. The dietary assessment included several questions about usual cooking methods for meats and doneness preference for beef. High intake of red meat was associated with increased risks for stomach and oesophageal cancers. Overall, broiling or frying of beef, chicken or pork was not associated with the risk of these tumours. Barbecuing/grilling, reported as the usual cooking method for a small number of study participants, was associated with an elevated risk of stomach and oesophageal cancers. After excluding those who reported usually barbecuing/grilling, a source of polycyclic aromatic hydrocarbons and heterocyclic amines (HCA), doneness level was evaluated as a surrogate for HCA exposure. Compared to a preference for rare/medium rare beef, odds ratios were 2.4 for medium, 2.4 for medium well and 3.2 for well done, a significant positive trend. Doneness level was not associated with a significant trend in risk of oesophageal cancer.
KW  - amines
KW  - beef
KW  - chicken meat
KW  - consumption
KW  - cooking
KW  - digestive tract
KW  - frying
KW  - heterocyclic nitrogen compounds
KW  - neoplasms
KW  - oesophagus
KW  - pigmeat
KW  - polycyclic hydrocarbons
KW  - poultry
KW  - stomach
KW  - Nebraska
KW  - USA
KW  - fowls
KW  - man
KW  - Gallus gallus
KW  - Gallus
KW  - Phasianidae
KW  - Galliformes
KW  - birds
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Northern Plains States of USA
KW  - West North Central States of USA
KW  - North Central States of USA
KW  - cancers
KW  - chickens
KW  - domesticated birds
KW  - esophagus
KW  - gastrointestinal tract
KW  - pork
KW  - United States of America
KW  - Meat Produce (QQ030) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.
AU  - Tabernero, C.
AU  - Zolotukhin, A. S.
AU  - Bear, J.
AU  - Schneider, R.
AU  - Karsenty, G.
AU  - Felber, B. K.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 1
SP  - 95
EP  - 101
SN  - 0022-538X
AD  - Tabernero, C.: Human Retrovirus Pathogenesis Group, National Cancer Institute-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972001537.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 63231-63-0. 
N2  - HIV-1 replication depends on the posttranscriptional regulation by the viral Rev protein and can be replaced with the posttranscriptional RNA control element (CTE) of the type D simian retroviruses. It identifies a sequence which shares only nucleotide sequences of the internal loops and secondary structure with the CTE and which is part of the novel murine intracisternal-A particle (IAP) retroelement, inserted within the transcribed mouse osteocalcin-related gene. This sequence, named CTEIAP, can replace the Rev-mediated regulation of HIV-1, hence it is a posttranscriptional regulatory element. Related elements have been identified in other IAPs. These results suggest that insertional mutagenesis can affect gene expression by providing a functional posttranscriptional control element. The CTEIAP and CTEs of the type D simian retroviruses represent a novel class of RNA elements characterized by unique sequences within the internal loops which are predicted to represent the interaction site with cellular factor(s). These findings suggest that such elements may be involved in posttranscriptional regulation of cellular mRNAs.
KW  - gene expression
KW  - human immunodeficiency viruses
KW  - identification
KW  - interactions
KW  - microbiology
KW  - nucleotide sequences
KW  - nucleotides
KW  - regulation
KW  - regulatory genes
KW  - replication
KW  - rev gene
KW  - rna
KW  - shares
KW  - structure
KW  - unique sequences
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - monkeys
KW  - Retroviridae
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Primates
KW  - DNA sequences
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - unique DNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Control of immunodeficiency and lymphoproliferation in mouse AIDS: studies of mice deficient in CD8+ T cells or perforin.
AU  - Tang Yao
AU  - Hügin, A. W.
AU  - Giese, N. A.
AU  - Gabrielle, L.
AU  - Chattopadhyay, S. K.
AU  - Fredrickson, T. N.
AU  - Kägi, D.
AU  - Hartley, J. W.
AU  - Morse, H. C. III
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 3
SP  - 1808
EP  - 1813
SN  - 0022-538X
AD  - Tang Yao: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, 9000 Rockville Pike, Bethesda, MD 20892-0760, USA.
N1  - Accession Number: 19972003129.  Publication Type: Journal Article.  Language: English. 
N2  - CD8+ T cells were previously shown to be important in preventing lymphoproliferation and immunodeficiency following infection of murine AIDS (MAIDS)-resistant mice with LP-BM5 mixture of murine leukaemia viruses. To evaluate further the mechanisms contributing to MAIDS resistance, the authors studied mice lacking CD8+ T cells or deficient in perforin owing to knockout of the β2-microglobulin (β2M) or perforin gene, respectively. In contrast to wild-type, MAIDS-resistant controls, , B10.A mice homozygous for the β2M mutation and B10.D2 mice homozygous for the perforin mutation were diagnosed as having MAIDS by five to eight weeks after infection by the criteria of lymphoproliferation, impaired proliferative responses to mitogens, and changes in cell population as judged by histopathology and flow cytometry. Unexpectedly, there was no progression of lymphoproliferation through 24 weeks, even though immune functions were severely compromised. Expression of the defective virus responsible for MAIDS was enhanced in spleens of the knockouts in comparison with wild-type mice. These results demonstrate that perforin-dependent functions of CD8+ T cells contribute to MAIDS resistance but that other, non-CD8+-dependent mechanisms are of equal or greater importance.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - CD8+ lymphocytes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - immunopathology
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD8+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003129&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable.
AU  - Sinclair, E.
AU  - Barbosa, P.
AU  - Feinberg, M. B.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 5
SP  - 3641
EP  - 3651
SN  - 0022-538X
AD  - Sinclair, E.: Office of AIDS Research, National Institutes of Health, 31 Center Dr., Building 31, Room 4C06, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004681.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
N2  - To establish more clearly whether the SIV and HIV-1 nef gene products are functionally analogous, the replication kinetics and infectivity of variants of SIVmac329 that either do (SIVnef+) or do not (SIVΔnef) encode intact nef gene products were compared. SIVnef+ replicates more rapidly than nef-defective viruses in both humans and rhesus peripheral blood mononuclear cells. As previously described for HIV-1 Nef, SIV Nef also enhances virus infectivity within each cycle of virus replication. As a strategy for evaluating the in vivo contribution of HIV-1 nef alleles and long terminal repeat regulatory sequences to the pathogenesis of immunodeficiency disease, SIV-HIV chimeras were constructed, in which the nef coding and U3 regulator regions of SIVmac329 were replaced by the corresponding regions from HIV-1/R73 (SIVR7nef+). SIVR7nef+ displays enhanced infectivity and accelerated replication kinetics in primary human and rhesus PBMC infections compared to its nef-defective counterpart. Converse chimeras, containing SIV Nef in an HIV-1 background (R7SIVnef+) also exhibit greater infectivity than matched nef-defective viruses (R7SIVΔnef). These data indicate that SIV Nef, like that of HIV-1, does enhance virus replication in primary cells in tissue culture and that HIV-1 and SIV Nef are functionally interchangeable in the context of both HIV-1 and SIV.
KW  - chimaeras
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infections
KW  - infectivity
KW  - kinetics
KW  - microbiology
KW  - nef gene
KW  - Nef protein
KW  - regulatory genes
KW  - replication
KW  - tissue culture
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - monkeys
KW  - simian immunodeficiency virus
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chimeras
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004681&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques.
AU  - Digilio, L.
AU  - Giri, A.
AU  - Cho, N.
AU  - Slattery, J.
AU  - Markham, P.
AU  - Franchini, G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 5
SP  - 3684
EP  - 3692
SN  - 0022-538X
AD  - Digilio, L.: Laboratory of Basic Research, National Cancer Institute, NIH, 37 Convent Dr., MSC 4255 Bldg. 37, Room 6A11, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972004682.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref.
N2  - STLV-2pan-p is a novel retrovirus distantly related to HTLV-II and displays a host range similar to that demonstrated for other HTLV and STLV strains.
KW  - hosts
KW  - HTLV infections
KW  - human diseases
KW  - microbiology
KW  - pathogenesis
KW  - phylogenetics
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Macaca
KW  - monkeys
KW  - Pan
KW  - Pan paniscus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltaretrovirus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pongidae
KW  - Pan
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - other Retroviridae
KW  - simian T-cell lymphotropic virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neurologic disease induced by polytropic murine retroviruses: neurovirulence determined by efficiency of spread to microglial cells.
AU  - Robertson, S. J.
AU  - Hasenkrug, K. J.
AU  - Chesebro, B.
AU  - Portis, J. L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 7
SP  - 5287
EP  - 5294
SN  - 0022-538X
AD  - Robertson, S. J.: Correspondence address [Portis, J. L.]: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 S. 4th St., Hamilton, MT 59840, USA.
N1  - Accession Number: 19972006022.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
N2  - Properties of the CNS infection by 2 of the neurovirulent viruses, Fr98 and Fr98/SE, and the non-neurovirulent virus Fr54 were examined in detail in an effort to identify features of these infections that correlate with neurovirulence. No differences were found between the neurovirulent and non-neurovirulent viruses with respect to the appearance of vacuolar degeneration, activation of astrocytes and microglial cells, regional distribution of virus, or the cell types infected in the brain. However, application of more quantitative measurements of viral protein expression in the brain revealed viral burden to be a consistent correlate of neurovirulence in this model. It is suggested that the neurovirulent viruses differ from the non-neurovirulent virus in the extent of their spread among microglial cells after initial virus entry into the brain.
KW  - brain
KW  - central nervous system
KW  - infection
KW  - infections
KW  - microbiology
KW  - neuroglia
KW  - pathogenesis
KW  - pathogenicity
KW  - properties
KW  - viral proteins
KW  - mice
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - CNS
KW  - glial cells
KW  - other Retroviridae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo.
AU  - Fujisawa, R.
AU  - McAtee, F. J.
AU  - Zirbel, J. H.
AU  - Portis, J. L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 7
SP  - 5355
EP  - 5360
SN  - 0022-538X
AD  - Fujisawa, R.: Correspondence address [Portis, J. L.]: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 S. 4th St., Hamilton, MT 59840, USA.
N1  - Accession Number: 19972006023.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
N2  - The processing of the protein expressed in fibroblasts was compared with that expressed in the spleens of infected mice. Expression of the glycosylated Gag precursor as well as its proteolytic cleavage appeared similar in vitro and in vivo, although differences in glycosylation were noted. However, whereas the L domain exhibited strictly a cytosolic orientation in fibroblasts in vitro, it was displayed at the cell surface on a subpopulation of spleen cells in vivo, suggesting an alternate orientation in the membrane.
KW  - experimental infections
KW  - fibroblasts
KW  - gag protein
KW  - in vitro
KW  - microbiology
KW  - precursors
KW  - proteolysis
KW  - spleen
KW  - structural genes
KW  - virulence
KW  - mice
KW  - Murine leukemia virus
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - murine leukaemia virus
KW  - other Retroviridae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites.
AU  - Zhang YiMing
AU  - Imamichi, H.
AU  - Imamichi, T.
AU  - Lane, H. C.
AU  - Falloon, J.
AU  - Vasudevachari, M. B.
AU  - Salzman, N. P.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 9
SP  - 6662
EP  - 6670
SN  - 0022-538X
AD  - Zhang YiMing: Correspondence address [Salzman, N. P.]: SAIC Frederick, Frederick Cancer Research & Development Center, National Cancer Institute, Frederick, MD, USA.
N1  - Accession Number: 19972008513.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 150378-17-9, 63231-63-0. 
N2  - Two different responses to the therapy were observed in a group of patients receiving the protease inhibitor indinavir. In one, suppression of virus replication occurred and has persisted for 90 weeks (bDNA, &lt;500 HIV-l RNA copies/ml). In the second group, a rebound in virus levels in plasma followed the initial sharp decline observed at the start of therapy. This was associated with the emergence of drug-resistant variants. Sequence analysis of the protease gene during the course of therapy revealed that in this second group there was a sequential acquisition of protease mutations at amino acids 46, 82, 54, 71, 89, and 90. In the six patients in this group, there was also an identical mutation in the gag p7/pl gag protease cleavage site. In three of the patients, this change was seen as early as 6 to 10 weeks after the start of therapy. In one patient, a second mutation occurred at the gag pl/p6 cleavage site, but it appeared 18 weeks after the time of appearance of the p7/pl mutation. Recombinant HIV-1 variants containing two or three mutations in the protease gene were constructed either with mutations at the p7/pl cleavage site or with wild-type (WT) gag sequences. When recombinant HIV-I-containing protease mutations at 46 and 82 was grown in MT2 cells, there was a 68% reduction in its rate of replication compared to the WT virus. Introduction of an additional mutation at the gag p7/pl protease cleavage site compensated for the partially defective protease gene. Similarly, rates of replication of viruses with mutations M46L/I, I54V, and V82A in protease were enhanced both in the presence and in the absence of Indinavir when combined with mutations in the gag p7/pl and the gag pl/p6 cleavage sites. Optimal rates of virus replication require protease cleavage of precursor polyproteins. A mutation in the cleavage site that enhanced the availability of a protein that was rate limiting for virus maturation would confer on that virus a significant growth advantage and may explain the uniform emergence of viruses with alterations at the p7/pl cleavage site. This is the first report of the emergence of mutations in the gag p7/pl protease cleavage sites in patients receiving protease therapy and identifies this change as an important determinant of HIV-l resistance to protease inhibitors in patient populations.
KW  - amino acids
KW  - antiviral agents
KW  - blood plasma
KW  - drug resistance
KW  - drug therapy
KW  - gag gene
KW  - gag protein
KW  - indinavir
KW  - inhibitors
KW  - mutations
KW  - precursors
KW  - proteinase inhibitors
KW  - proteinases
KW  - replication
KW  - RNA
KW  - treatment
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antiretrovirals
KW  - chemotherapy
KW  - cleavage sites
KW  - human immunodeficiency virus type 1
KW  - plasma (blood)
KW  - protease gene
KW  - protease inhibitors
KW  - proteases
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008513&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes.
AU  - Lebedeva, I.
AU  - Fujita, K.
AU  - Nihrane, A.
AU  - Silver, J.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 9
SP  - 7061
EP  - 7067
SN  - 0022-538X
AD  - Lebedeva, I.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980500374.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Semliki Forest virus vectors encoding murine leukaemia virus (MLV) envelope protein with a truncated cytoplasmic tail generate submicrometre, cell-associated, membranous particles which transmit replication-competent vector RNA specifically to cells bearing the MLV receptor. Such "minimal" viruses could have applications as retroviral vaccines or in the study of virus evolution.
KW  - arboviruses
KW  - disease vectors
KW  - envelope proteins
KW  - gene expression
KW  - infections
KW  - molecular genetics
KW  - vectors
KW  - viral proteins
KW  - murine leukemia virus
KW  - Semliki Forest virus
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Alphavirus
KW  - Togaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - arthropod-borne viruses
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500374&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection.
AU  - Nowak, M. A.
AU  - Lloyd, A. L.
AU  - Vasquez, G. M.
AU  - Wiltrout, T. A.
AU  - Wahl, L. M.
AU  - Bischofberger, N.
AU  - Williams, J.
AU  - Kinter, A.
AU  - Fauci, A. S.
AU  - Hirsch, V. M.
AU  - Lifson, J. D.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 10
SP  - 7518
EP  - 7525
SN  - 0022-538X
AD  - Nowak, M. A.: Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Building 535, Room 509, Frederick, MD 21702, USA.
N1  - Accession Number: 19972010765.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 63231-63-0. 
N2  - Mathematical modelling of viral replication dynamics, based on sequential measurements of levels of virion-associated RNA in plasma during antiretroviral treatment, has led to fundamental new insights into HIV-1 pathogenesis. The SIV-infected macaque model was used to perform detailed measurements and mathematical modelling during primary infection and during treatment of established infection with the antiretroviral drug (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA). The calculated clearance half-life for productively infected cells during resolution of the peak viraemia of primary infection was of the order of 1 day, with slightly shorter clearance half-lives calculated during PMPA treatment. Viral reproduction rates upon discontinuation of PMPA treatment after 2 weeks were approximately twofold greater than those obtained just prior to initiation of treatment in the same animals, likely reflecting accumulation of susceptible target cells during treatment. The basic reproductive ratio (R0) for the spread of SIV infection in vivo, which represents the number of productively infected cells derived from each productively infected cell at the beginning of infection, was also estimated. This parameter quantifies the extent to which antiviral therapy or vaccination must limit the initial spread of virus to prevent establishment of chronic disseminated infection. The results thus provide an important guide for efforts to develop vaccines against SIV and, by extension, HIV.
KW  - animal models
KW  - antiviral agents
KW  - blood plasma
KW  - chronic course
KW  - disseminated infections
KW  - drug therapy
KW  - dynamics
KW  - half life
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - mathematical models
KW  - models
KW  - replication
KW  - reproduction
KW  - RNA
KW  - therapy
KW  - treatment
KW  - vaccination
KW  - vaccines
KW  - viral replication
KW  - Macaca
KW  - monkeys
KW  - simian immunodeficiency virus
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - plasma (blood)
KW  - primary infections
KW  - ribonucleic acid
KW  - therapeutics
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010765&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge.
AU  - Buge, S. L.
AU  - Alipanah, S.
AU  - Markham, A. P.
AU  - Cheng, S.
AU  - Kalyan, N.
AU  - Miller, C. J.
AU  - Lubeck, M.
AU  - Udem, S.
AU  - Eldridge, J.
AU  - Robert-Guroff, M.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 11
SP  - 8531
EP  - 8541
SN  - 0022-538X
AD  - Buge, S. L.: Basic Research Laboratory, National Cancer Institute, Building 37, Room 6A11, 37 Convent Dr., Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19972010798.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref.
N2  - This study establishes that the rhesus macaque model is suitable for assessing adenovirus (Ad)-based SIV vaccines. Using a combination protocol involving (i) priming with an Ad5 host range mutant (Ad5hr)-SIVsmenv recombinant that efficiently replicates in monkey cells and expresses the SIVsm envelope gene and (ii) boosting with a native subunit, SIVmac251 gp120, it is demonstrated that humoral, cellular, and mucosal immune responses are elicited in rhesus macaques. It is further shown that this approach, in which only SIV envelope was used as immunogen, resulted in significantly decreased viral burdens following infection with the virulent SIVmac251 isolate by the vaginal route. Inclusion of additional SIV components in the vaccine should result in greater protective efficacy. The availability of this new rhesus macaque model will expedite evaluation of additional Ad recombinants in this highly promising combination vaccine approach and will facilitate testing of protective efficacy of the Ad-based vaccine strategy against multiple routes of viral transmission.
KW  - ENV gene
KW  - HIV infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - infection
KW  - mucosa
KW  - responses
KW  - vaccines
KW  - vagina
KW  - virulence
KW  - Macaca
KW  - Macaca mulatta
KW  - monkeys
KW  - simian immunodeficiency virus
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Macaca
KW  - HUMAN IMMUNODEFICIENCY VIRUS
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - mucous membrane
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010798&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A small region of the ecotropic murine leukemia virus (MuLV) gag gene profoundly influences the types of polytropic MuLVs generated in mice.
AU  - Lavignon, M.
AU  - Richardson, J.
AU  - Evans, L. H.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 11
SP  - 8923
EP  - 8927
SN  - 0022-538X
AD  - Lavignon, M.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19972010809.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref.
N2  - These studies identified a region of the MuLv genome which encodes the nucleocapsid protein and a portion of the viral protease as the only region that influenced the difference in polytropic-MuLV generation by Mo-MuLV and F-MuLV57.
KW  - genomes
KW  - monoclonal antibodies
KW  - nucleocapsid proteins
KW  - proteinases
KW  - Murine leukemia virus
KW  - Retroviridae
KW  - viruses
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - murine leukaemia virus
KW  - proteases
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010809&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection.
AU  - Lifson, J. D.
AU  - Nowak, M. A.
AU  - Goldstein, S.
AU  - Rossio, J. L.
AU  - Kinter, A.
AU  - Vasquez, G.
AU  - Wiltrout, T. A.
AU  - Brown, C.
AU  - Schneider, D.
AU  - Wahl, L.
AU  - Lloyd, A. L.
AU  - Williams, J.
AU  - Elkins, W. R.
AU  - Fauci, A. S.
AU  - Hirsch, V. M.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 12
SP  - 9508
EP  - 9514
SN  - 0022-538X
AD  - Lifson, J. D.: Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute-Frederick Cancer Resarch and Development Center, Bldg 535, Rm 509, Frederick, MD 21702.
N1  - Accession Number: 19982000527.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref. Registry Number: 63231-63-0. 
N2  - Different patterns of viral replication correlate with the natural history of disease progression in humans and macaques infected with HIV-1 and SIV, respectively. However, the viral and host factors influencing these patterns of viral replication in vivo are poorly understood. We intensively studied viral replication in macaques receiving identical inocula of SIV. Marked differences in viral replication patterns were apparent within the first week following inoculation, a time prior to the development of measurable specific immune effector responses to viral antigens. Plasma viral RNA levels measured on day 7 postinoculation correlated with levels measured in the postacute phase of infection. Differences in the susceptibility of host cells from different animals to in vitro SIV infection correlated with the permissiveness of the animals for early in vivo viral replication and hence with the postacute set point level of plasma viremia. These results suggest that host factors that exert their effects prior to full development of specific immune responses are critical in establishing the in vivo viral replication pattern and associated clinical course in subjects infected with SIV and, by extension, with HIV-1.
KW  - blood plasma
KW  - clinical aspects
KW  - disease course
KW  - HIV-1 infections
KW  - hosts
KW  - human diseases
KW  - immune response
KW  - in vitro
KW  - infection
KW  - pathogenesis
KW  - replication
KW  - responses
KW  - RNA
KW  - susceptibility
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - Macaca
KW  - man
KW  - monkeys
KW  - simian immunodeficiency virus
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - clinical picture
KW  - disease progression
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - plasma (blood)
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000527&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Promonocytic U937 subclones expressing CD4 and CXCR4 are resistant to infection with and cell-to-cell fusion by T-cell-tropic human immunodeficiency virus type 1.
AU  - Moriuchi, H.
AU  - Moriuchi, M.
AU  - Arthos, J.
AU  - Hoxie, J.
AU  - Fauci, A. S.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 12
SP  - 9664
EP  - 9671
SN  - 0022-538X
AD  - Moriuchi, H.: National Institutes of Health, Bldg 10, Rm 6A11, 10 Center Dr., MSC-1576, Bethesda, MD 20892-1576.
N1  - Accession Number: 19982000531.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
N2  - Different strains of HIV-1 vary markedly in the ability to infect cells of the monocyte/macrophage (M/M) lineage. M/M are generally resistant to infection with T-cell-tropic (T-tropic) strains of HIV-1. Recently, the chemokine receptors CCR5 and CXCR4 were identified as cofactors for fusion/entry of macrophage- and T-tropic strains of HIV-1, respectively. To investigate the mechanisms of resistance of M/M to T-tropic HIV-1 infection, a number of subclones of the U937 pro-monocytic cell line were examined. It was found that certain subclones of U937 (plus clones) could, while others (minus clones) could not, support replication of T-tropic strains of HIV-1. It was demonstrated that (i) both minus and plus clones support HIV-1 replication when transfected with an infectious molecular cDNA clone of a T-tropic HIV-1; (ii) minus clones do not, but plus clones do, efficiently support fusion with cells expressing HIV-1 IIIB Env; (iii) both plus and minus clones (with the exception of one clone) express physiologically functional CXCR4 protein as well as CD4 on the cell surface; (iv) introduction of CXCR4 into the CXCR4-negative clone does not restore fusogenicity with or susceptibility to T-tropic HIV-1; and (v) a ligand (stromal cell-derived factor 1) for or a monoclonal antibody (12G5) to CXCR4 does not effectively inhibit HIV-mediated cell-to-cell fusion of U937 cells. These data indicate that resistance to T-tropic HIV-1 infection of U937 minus clones occurs at fusion/ entry events and that expression of functional CXCR4 and CD4 is not a sole determinant for susceptibility to T-tropic HIV-1 infection; furthermore, they suggest that other factors are positively or negatively involved in HIV-mediated cell-to-cell fusion in U937 pro-monocytic cells.
KW  - antibodies
KW  - CD4 antigens
KW  - chemokines
KW  - clones
KW  - cofactors
KW  - complementary DNA
KW  - cytokines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - monoclonal antibodies
KW  - pathogenesis
KW  - receptors
KW  - replication
KW  - resistance
KW  - strains
KW  - susceptibility
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - cDNA
KW  - cloning
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000531&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficient expression by an alphavirus replicon of a functional ribozyme targeted to human immunodeficiency virus type 1.
AU  - Smith, S. M.
AU  - Maldarelli, F.
AU  - Jeang KuanTeh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 12
SP  - 9713
EP  - 9721
SN  - 0022-538X
AD  - Smith, S. M.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bulding 4, Room 306, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19980500200.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 63231-63-0. 
N2  - Intracellular applications of ribozymes have been limited partly by the availability of suitable high-expression systems. For RNA effectors, consideration of an RNA virus vector system for delivery and expression is reasonable. It is shown that alphavirus replicons can be highly efficient non-integrating ribozyme-expressing vectors. Using a hammerhead ribozyme targeted to a highly conserved sequence in the U5 region of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat, it was demonstrated that a full-length 8.3-kb Semliki Forest virus ribozyme (SFVRz) chimeric RNA maintains catalytic activity. SFVRz is packaged into viral particles, and these particles transduce mammalian cells efficiently. SFVRz-transduced BHK cells were found to produce large amounts of genomic and subgenomic forms of ribozyme-containing RNAs that are functional in cleaving a U5-tagged mRNA. The RNase protection assay shows that HIV-1 U5-chloramphenicol acetyltransferase mRNA expressed intracellularly from an RNA polymerase II promoter is quantitatively eliminated in SFVRz-transduced BHK cells.
KW  - antiviral agents
KW  - enzymes
KW  - gene expression
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - RNA
KW  - Alphavirus
KW  - Semliki Forest virus
KW  - Togaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Alphavirus
KW  - human immunodeficiency virus
KW  - ribonucleic acid
KW  - ribozymes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500200&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.
AU  - Kolenitchenko, V.
AU  - King, L.
AU  - Riva, A.
AU  - Tani, Y.
AU  - Korsmeyer, S. J.
AU  - Cohen, D. I.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1997///
VL  - 71
IS  - 12
SP  - 9753
EP  - 9763
SN  - 0022-538X
AD  - Kolenitchenko, V.: Basic Research Laboratory, National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm. 6A11, Bethesda, MD 20892-4255.
N1  - Accession Number: 19982000534.  Publication Type: Journal Article.  Language: English.  Number of References: 85 ref.
N2  - The relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1 (HIV-1) was investigated, by employing diverse strategies to inhibit PCD or to detect its common end-stage sequelae. When Bcl-2-transfected cell lines were infected with HIV-l, their viability was only slightly higher than that of control infections. Although the adenovirus ElB 19-kDa protein has been reported to be a stronger competitor of apoptosis than Bcl-2, it did not inhibit HIV-mediated cell death better than Bcl-2 protein. Competition for Fas ligand or inactivation of the Fas pathway secondary to intracellular mutation (MOLT-4 T cells) also had modest effects on overall cell death during acute HIV infection. In contrast to these observations with HIV infection or with HIV envelope-initiated cell death, Tat-expressing cell lines were much more susceptible (200% enhancement) to Fas-induced apoptosis than controls and Bcl-2 overexpression strongly (75%) inhibited this apoptotic T-cell death. PCD associated with FasR ligation resulted in the cleavage of common interleukin-1β converting enzyme (ICE)-protease targets, poly(ADP-ribose) polymerase (PARP) and pro-ICE, whereas cleaved products were not readily detected during HIV infection of peripheral blood mononuclear cells or T-cell lines even during periods of extensive cell death. These results indicate that one important form of HIV-mediated cell killing proceeds by a pathway that lacks the characteristics of T-cell apoptosis. The authors' observations support the conclusion that at least 2 HIV genes (env and tat) can kill T cells by distinct pathways and that an envelope-initiated process of T-cell death can be discriminated from apoptosis by many of the properties most closely associated with apoptotic cell death.
KW  - acute infections
KW  - apoptosis
KW  - cell lines
KW  - death
KW  - genes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inactivation
KW  - infection
KW  - ligature
KW  - mutations
KW  - properties
KW  - T lymphocytes
KW  - Adenoviridae
KW  - human adenovirus
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Mastadenovirus
KW  - Adenoviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - ligation
KW  - mononuclear cells
KW  - peripheral blood
KW  - severe infections
KW  - strategies
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000534&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current status of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccine development: memorandum from a joint WHO/NIAID meeting.
AU  - Murphy, B. R.
AU  - Collins, P. L.
JO  - Bulletin of the World Health Organization
JF  - Bulletin of the World Health Organization
Y1  - 1997///
VL  - 75
IS  - 4
SP  - 307
EP  - 313
SN  - 0042-9686
AD  - Murphy, B. R.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
N1  - Accession Number: 19982006620.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Subject Subsets: Public Health
N2  - A summary of a joint WHO/NIAID meeting on the current status of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccine development, held in Bethesda, Maryland, USA, 30 September-October 1996, is presented. The worldwide impact of RSV and PIV3, current status of development of RSV and PIV3 vaccines, applications of recombinant DNA technology to the development and characterization of vaccines and to the understanding of viral pathogenesis, are discussed.
KW  - disease prevention
KW  - human diseases
KW  - parainfluenza viruses
KW  - reviews
KW  - vaccine development
KW  - vaccines
KW  - viral diseases
KW  - human respiratory syncytial virus
KW  - man
KW  - Pneumovirus
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Pneumovirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Paramyxovirinae
KW  - parainfluenza virus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006620&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.
AU  - Fujita, K.
AU  - Omura, S.
AU  - Silver, J.
JO  - Journal of General Virology
JF  - Journal of General Virology
Y1  - 1997///
VL  - 78
IS  - 3
SP  - 619
EP  - 625
SN  - 0022-1317
AD  - Fujita, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004274.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
N2  - HIV-1 encodes 3 genes, Vpu, Env and Nef, that decrease cellular CD4. Vpu and Env act cooperatively to accelerate degradation of CD4 in the endoplasmic reticulum. It is reported that Vpu/Env-induced CD4 degradation is inhibited by lactacystin, a specific inhibitor of the proteasome, and by other proteasome inhibitors, but not by non-proteasome protease inhibitors. It is also noted that Vpu has amino acid sequence homology with a segment of IκB known to be involved in proteasome-mediated degradation, suggesting that HIV-1 could have transduced cellular sequences to enhance down-regulation of CD4.
KW  - amino acid sequences
KW  - antiviral agents
KW  - cd4 antigens
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibitors
KW  - microbiology
KW  - proteinase inhibitors
KW  - proteinases
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - CD4
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - protease inhibitors
KW  - proteases
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence variations and viral genomic state of human papillomavirus type 16 in penile carcinomas from Ugandan patients.
AU  - Tornesello, M. L.
AU  - Buonaguro, F. M.
AU  - Meglio, A.
AU  - Buonaguro, L.
AU  - Beth-Giraldo, E.
AU  - Giraldo, G.
JO  - Journal of General Virology
JF  - Journal of General Virology
Y1  - 1997///
VL  - 78
IS  - 9
SP  - 2199
EP  - 2208
SN  - 0022-1317
AD  - Tornesello, M. L.: Division of Viral Oncology, National Cancer Institute, 'Fondazione Pascale', I-80131 Naples, Italy.
N1  - Accession Number: 19982004686.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
N2  - Sequence variations in the E6/E7 (nt 34-880) and the L1 (nt 6584-7035) ORFs, and in the long control region (LCR) (nt 7289-93) of human papillomavirus type 16 (HPV-16) were analysed in five penile carcinoma biopsies obtained from Ugandan patients in 1972-80. Uganda is a country with a high incidence of genital cancers. All five isolates were classified as members of African-1 lineage (Af1) by phylogenetic analysis based on long control region (LCR) sequences. The E6 gene phylogenetic analysis, however, showed that four isolates fell into a new subclass designated Af1-u. This subclass, characterized by three point mutations located at the 5′ end of the E6 gene with resulting changes in amino acids at positions 10 and 14, is distinguishable from the Af1 class by the absence of synonymous mutations at nt 286 and 289. The nonsynonymous substitution at nt 335 was present in three out of five samples. The E6 Af1 mutation pattern was present in only a single Ugandan HPV-16 isolate. Nucleotide sequence analysis of the E7 and L1 regions did not allow any Af1 subclass identification. The physical state of the viral DNA in these samples was characterized by polymerase chain reaction (PCR) and Southern blot analysis. Oligonucleotides which enable amplification of the full length E2 region (nt 2734-3872) failed to amplify the target sequence in four out of five samples, suggesting disruption of the E2 ORF and integration of the HPV genome into the human DNA. Southern blot analysis confirmed the virus integration status.
KW  - carcinoma
KW  - DNA sequencing
KW  - neoplasms
KW  - nucleotide sequences
KW  - open reading frames
KW  - polymerase chain reaction
KW  - southern blotting
KW  - human papillomaviruses
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Papillomaviridae
KW  - cancers
KW  - DNA sequences
KW  - human papillomavirus
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - ORFs
KW  - Papovaviridae
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Syncytium formation induced by human immunodeficiency virus type 1 isolates correlates with affinity for CD4.
AU  - Watkins, B. A.
AU  - Crowley, R.
AU  - Davis, A. E.
AU  - Louie, A. T.
AU  - Reitz, M. S. Jr.
JO  - Journal of General Virology
JF  - Journal of General Virology
Y1  - 1997///
VL  - 78
IS  - 10
SP  - 2513
EP  - 2522
SN  - 0022-1317
AD  - Watkins, B. A.: Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Correspondence address [Watkins, B. A.]: Matritech, Inc., 330 Nevada St, Newton, MA 02160, USA.
N1  - Accession Number: 19982000344.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref.
N2  - This study investigated the contributions of different regions of the env gene to syncytia induction using chimeric viruses that contain part of the genome of a strain that lacks this ability (HIV-1Ba-L) within the genome of a virus that can form syncytia (HIV-1HXB-2). When tested in two cell lines susceptible to both parental viruses, as well as in primary cells, these chimeric viruses demonstrated that the ability to induce syncytia formation was determined by regions of env outside the V3 loop, which encompass residues that contribute to the binding of CD4 by gp120. Further investigation failed to show any difference in the expression of gp120 on the cell surface or cell adhesion molecules by cells infected with SI or NSI variants that would explain the observed differences in the ability to form syncytia. Assays of relative affinity for CD4 indicated that gp 120 from SI variants showed a significantly higher affinity for CD4 than gp 120 from NSI variants. These observations suggest that areas of the HIV-1 env gene contributing to the CD4 binding site may also contribute to the determination of syncytium-inducing (SI) and non-syncytium-inducing (NSI) phenotypes.
KW  - adhesion
KW  - binding
KW  - CD4 antigens
KW  - cell lines
KW  - cells
KW  - clinical aspects
KW  - ENV gene
KW  - envelope protein gp120
KW  - formation
KW  - genomes
KW  - human immunodeficiency viruses
KW  - pathogenesis
KW  - phenotypes
KW  - prognosis
KW  - proteins
KW  - strains
KW  - surface proteins
KW  - syncytia
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - clinical picture
KW  - gp120
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - membrane proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000344&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differences in corticotropin-releasing hormone-stimuated adrenocorticotropin and cortisol before and after weight loss.
AU  - Yanovski, J. A.
AU  - Yanovski, S. Z.
AU  - Gold, P. W.
AU  - Chrousos, G. P.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1997///
VL  - 82
IS  - 6
SP  - 1874
EP  - 1878
SN  - 0021-972X
AD  - Yanovski, J. A.: National Institutes of Health, Building 10, Room 10N62-1862, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19971409410.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 6000-74-4, 125-04-2, 13609-67-1, 9015-71-8, 50-03-3, 50-23-7.  Subject Subsets: Human Nutrition
N2  - The hypothalamic-pituitary-adrenal (HPA) axis of 34 healthy obese women (35.9±7.3 years old; body mass index, 40.2±7.9 kg/m²) was studied before and after a 21.0±7.9-kg weight loss induced by a 26-week weight loss programme that included 12 weeks of a 3350 kJ/day (800 kcal/day) liquid formula diet, 6 weeks of gradual refeeding and 6 weeks of energy stabilization at 5020-6280 kJ/day (1200-1500 kcal/day). Obese subjects were evaluated twice: before energy restriction and during the last 3 weeks of energy stabilization with a 3-h evening 1 µg/kg ovine corticotrophin-releasing-hormone (oCRH) stimulation test. CRH-stimulated ACTH and cortisol values were compared to those of a control group of 12 normal weight women (33.9±6.6 years old). Before energy restriction, ACTH and cortisol responses to oCRH were similar in obese women and normal weight controls. Weight loss did not significantly alter the ACTH response to oCRH; however, the total plasma cortisol response to oCRH decreased with weight loss (area under the curve, 96 320±21 040 nmol/litre-1 min-1 before weight loss; 82 450±22 460 nmol/litre-1 min-1 after weight loss; P&lt;0.001). Cortisol-binding globulin also decreased after weight loss (2 270±1 050) compared to values obtained before weight loss (3 590±1 360; P&lt;0.001) or to those of normal weight controls (3 910±1 400 nmol/litre; P&lt;0.001). Assay for plasma free cortisol, before or 180 min after oCRH treatment, showed no significant changes in cortisol responses resulting from weight loss. As plasma free cortisol was not altered by weight reduction, the decrease in the total cortisol response to oCRH after weight loss appears to be secondary to significant decreases in cortisol-binding globulin. It is concluded that when obese women lose large amounts of weight with a 3350 kJ/day, very low energy diet, such weight reduction does not significantly affect the HPA axis.
KW  - binding proteins
KW  - corticoliberin
KW  - hydrocortisone
KW  - obesity
KW  - weight reduction
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - corticotropin releasing factor
KW  - corticotropin releasing hormone
KW  - cortisol
KW  - fatness
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction.
AU  - Lane, M. A.
AU  - Ingram, D. K.
AU  - Ball, S. S.
AU  - Roth, G. S.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1997///
VL  - 82
IS  - 7
SP  - 2093
EP  - 2096
SN  - 0021-972X
AD  - Lane, M. A.: Gerontology Research Center, Nathan W. Shock Laboratories, National Institute on Aging, National Institutes of Health, Johns Hopkins University Bayview Campus, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19971411380.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 53-43-0, 14808-79-8.  Subject Subsets: Human Nutrition
N2  - Male and female rhesus monkeys exhibited a steady, age-related decline in serum dehydroepiandrosterone [prasterone] sulfate (DHEAS). This decline met several criteria for a biomarker of aging, including cross-sectional and longitudinal linear decreases with age and significant stability of individual differences over time. In addition, the proportional age-related loss of DHEAS in rhesus monkeys was over twice the rate of decline observed in man. Most important was the finding that, in rhesus monkeys, energy restriction (70% of ad libitum intake), which extends life span and retards aging in laboratory rodents, slowed the postmaturational decline in serum DHEAS levels. This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species.
KW  - aging
KW  - food restriction
KW  - markers
KW  - prasterone
KW  - sulfate
KW  - monkeys
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - dehydroepiandrosterone
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411380&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin 1α increases serum leptin concentrations in humans.
AU  - Janik, J. E.
AU  - Curti, B. D.
AU  - Considine, R. V.
AU  - Rager, H. C.
AU  - Powers, G. C.
AU  - Alvord, W. G.
AU  - Smith, J. W., II
AU  - Gause, B. L.
AU  - Kopp, W. C.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1997///
VL  - 82
IS  - 9
SP  - 3084
EP  - 3086
SN  - 0021-972X
AD  - Janik, J. E.: Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, Maryland 20892-1906, USA.
N1  - Accession Number: 19971412848.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 169494-85-3.  Subject Subsets: Human Nutrition
N2  - Serum leptin concentrations were measured in patients with cancer before and after administration of recombinant human interleukin (IL)-1α. 14 patients (8 men and 6 women aged 32-70 years) received IL-1α 0.03, 0.1 or 0.3 µg/kg daily for 5 days. Serum leptin concentrations increased in all but 2 patients within 24 h after the first dose. The increase in leptin was correlated directly with IL-1α dose (P=0.0030). Despite continued administration of IL-1α, serum leptin concentrations returned to pretreatment levels by day 5 of therapy. It is concluded that an increase in serum leptin concentrations may be 1 mechanism by which anorexia is induced by IL-1α. However, tachyphylaxis of the leptin response suggests that other mechanisms also are involved.
KW  - blood
KW  - cytokines
KW  - hormones
KW  - interleukin 1
KW  - interleukins
KW  - leptin
KW  - neoplasms
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412848&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Schistosoma mansoni: unisexual infections sensitize mice for granuloma formation around intravenously injected eggs.
AU  - Cheever, A. W.
AU  - Lewis, F. A.
AU  - Wynn, T. A.
JO  - Parasitology Research
JF  - Parasitology Research
Y1  - 1997///
VL  - 83
IS  - 1
SP  - 57
EP  - 59
SN  - 0044-3255
AD  - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970800902.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Helminthology
N2  - Mice carrying unisexual infections with male or female Schistosoma mansoni for 9 weeks developed accelerated and augmented reactions to S. mansoni eggs injected iv. The size of circumoval granulomas observed in the lungs of unisexually infected mice did not differ significantly from the reactions seen in bisexually infected mice. Tissue eosinophilia in the granulomas was also augmented similarly over that in naive mice by unisexual or bisexual infection. The cross-reactivity between worm and egg antigens is considered relevant to the development of acute toxaemic schistosomiasis mansoni and, perhaps, to the consideration of antigens to be used for vaccination against S. mansoni infection.
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - immunopathology
KW  - laboratory animals
KW  - ova
KW  - parasites
KW  - pathogenesis
KW  - schistosomiasis
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - granulomata
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800902&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium falciparum: a high proportion of parasites from a population of the Dd2 strain are able to invade erythrocytes by an alternative pathway.
AU  - Soubes, S. C
AU  - Wellems, T. E.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1997///
VL  - 86
IS  - 1
SP  - 79
EP  - 83
SN  - 0014-4894
AD  - Soubes, S. C: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980803304.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9001-67-6.  Subject Subsets: Protozoology
N2  - Evidence is presented that a switch in gene expression from inability to ability to invade neuraminidase [sialidase]-treated erythrocytes has occurred in a high proportion of parasites in a population of the Plasmodium falciparum Dd2 clone. The high proportion of the Dd2-Nm (sialic acid-independent) subpopulation (1 of 217, 0.46%) argues for the existence of high frequency mutations, allowing the switch to an alternative pathway of invasion rather than the selection of low mutation events.
KW  - cell invasion
KW  - erythrocytes
KW  - gene expression
KW  - genetics
KW  - host parasite relationships
KW  - human diseases
KW  - malaria
KW  - mutations
KW  - parasites
KW  - sialidase
KW  - strains
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - blood red cells
KW  - exo-alpha-sialidase
KW  - neuraminidase
KW  - parasite host relationships
KW  - red blood cells
KW  - sialic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803304&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interaction between timing of perinatal human immunodeficiency virus infection and the design of preventive and therapeutic interventions.
AU  - Mofenson, L. M.
JO  - Acta Paediatrica, Supplement
JF  - Acta Paediatrica, Supplement
Y1  - 1997///
VL  - 86
IS  - 421
SP  - 1
EP  - 9
CY  - Stockholm; Sweden
PB  - Scandinavian University Press
SN  - 0803-5326
AD  - Mofenson, L. M.: Pediatric, Adolescent & Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health & Human Development, National Institutes of Health, Rockville, MD, USA.
N1  - Accession Number: 19972006612.  Publication Type: Journal Article.  Language: English.  Registry Number: 30516-87-1. 
N2  - In 1994, the hypothesis that transmission of HIV from mother to child could be interrupted became a reality when it was shown that a regimen of zidovudine given to HIV-infected pregnant women and their newborn infants could reduce the risk of perinatal transmission by two-thirds. An understanding of the pathogenesis of transmission is crucial for interpreting these results, for design of future interventions and for understanding the natural history of perinatal HIV infection. This paper reviews current information regarding the timing of and risk factors for perinatal HIV transmission, and the relationship between the timing of transmission and design of efforts to interrupt transmission and to slow disease progression in infected infants.
KW  - antiviral agents
KW  - children
KW  - disease course
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - intervention
KW  - maternal transmission
KW  - mothers
KW  - neonates
KW  - pregnancy
KW  - prevention
KW  - prophylaxis
KW  - regimens
KW  - relationships
KW  - reviews
KW  - risk factors
KW  - transmission
KW  - women
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - chemotherapy
KW  - disease progression
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - newborn infants
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
KW  - Women (UU500) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006612&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vertical transmission of human immunodeficiency virus type 1 : insights from studies of multiple pregnancies.
AU  - Goedert, J. J.
JO  - Acta Paediatrica, Supplement
JF  - Acta Paediatrica, Supplement
Y1  - 1997///
VL  - 86
IS  - 421
SP  - 56
EP  - 59
CY  - Stockholm; Sweden
PB  - Scandinavian University Press
SN  - 0803-5326
AD  - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, Suite 434, Rockville, MD 20852, USA.
N1  - Accession Number: 19972006706.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref.
KW  - acquired immune deficiency syndrome
KW  - disease course
KW  - epidemiology
KW  - experiments
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunogenetics
KW  - infection
KW  - maternal transmission
KW  - mothers
KW  - multiple births
KW  - pregnancy
KW  - registration
KW  - survival
KW  - susceptibility
KW  - transmission
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cloning
KW  - disease progression
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006706&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reducing the risk of perinatal HIV-1 transmission with zidovudine: results and implications of AIDS Clinical Trials Group protocol 076.
AU  - Mofenson, L. M.
JO  - Acta Paediatrica, Supplement
JF  - Acta Paediatrica, Supplement
Y1  - 1997///
VL  - 86
IS  - 421
SP  - 89
EP  - 96
CY  - Stockholm; Sweden
PB  - Scandinavian University Press
SN  - 0803-5326
AD  - Mofenson, L. M.: Pediatric, Adolescent & Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health & Human Development, National Institutes of Health, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA.
N1  - Accession Number: 19972006713.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 30516-87-1. 
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - clinical aspects
KW  - clinical trials
KW  - drug therapy
KW  - guidelines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - maternal transmission
KW  - mothers
KW  - prophylaxis
KW  - public health
KW  - transmission
KW  - treatment
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - AZT
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - recommendations
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Health Services (UU350) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006713&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Progress in prevention of perinatal HIV-1.
AU  - Fowler, M. G.
AU  - Mofenson, L.
JO  - Acta Paediatrica, Supplement
JF  - Acta Paediatrica, Supplement
Y1  - 1997///
VL  - 86
IS  - 421
SP  - 97
EP  - 103
CY  - Stockholm; Sweden
PB  - Scandinavian University Press
SN  - 0803-5326
AD  - Fowler, M. G.: Efficacy Trials Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19972006714.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 30516-87-1. 
KW  - antiviral agents
KW  - clinical aspects
KW  - clinical trials
KW  - disease prevention
KW  - disseminated infections
KW  - drug therapy
KW  - HIV-1 infections
KW  - human diseases
KW  - maternal transmission
KW  - mothers
KW  - neonates
KW  - prophylaxis
KW  - reviews
KW  - transmission
KW  - zidovudine
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AZT
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - newborn infants
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006714&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.
AU  - Freed, E. O.
AU  - Englund, G.
AU  - Maldarelli, G.
AU  - Martin, M. A.
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1997///
VL  - 88
IS  - 2
SP  - 171
EP  - 174
SN  - 0092-8674
AD  - Freed, E. O.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972003203.  Publication Type: Journal Article.  Language: English. 
N2  - The authors comment on studies by Gallay et al.(Cell, [1995] 80 379-388; 83 569-576). In reply, Trono and Gallay comment: Freed et al. previously questioned the role of matrix protein (MA) NLS in HIV-1 infection of macrophages. In line with this position, they now present data contesting the participation of the C-terminal phosphorylation of MA in this process. To address this controversy, Trono and Gallay first compared the status of MA tyrosine phosphorylation of their and Freed et al.'s viruses. Several points could be made. First, no significant difference was noted between their and Freed et al.'s viruses. Second, the phenotype of the Vpr/MA tyrosine mutant viruses systematically correlated with that of the Vpr/MA NLS variants. Third, the phenotype of both types of MA/Vpr-defective strains was linked to the multiplicity of infection (m.o.i.), so that these viruses exhibited wild-type replication kinetics when a high initial inoculum (i.e. 40 ng p24 antigen per 2 × 105 cells) was used, whereas their growth was severely impaired when the cells were exposed to a lower dose of virus (i.e. 0.2 or 2 ng p24 antigen per 2 × 105 cells), within the range of that used in all previous analyses. In summary, these results are consistent with the claim (see above references and Bukrinskaya et al. Proceedings of the National Academy of Sciences USA, [1996] 9 367-371) that MA tyrosine phosphorylation participates in facilitating HIV-1 nuclear import. Even though under some experimental conditions the point made by Freed et al. is valid, Trono and Gallay feel at this stage that technical differences, for instance related to the use of different m.o.i. values, explain the discrepancy between the different groups' results.
KW  - core proteins
KW  - HIV-1 infections
KW  - human diseases
KW  - infection
KW  - macrophages
KW  - microbiology
KW  - pathogenesis
KW  - phenotypes
KW  - phosphorylation
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003203&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies.
AU  - Lubin, J. H.
AU  - Boice, J. D., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 1
SP  - 49
EP  - 57
SN  - 0027-8874
AD  - Lubin, J. H.: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972008019.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 10043-92-2.  Subject Subsets: Public Health
N2  - To provide more information on the risk of lung cancer from indoor radon, a meta-analysis of all case-control studies that included at least 200 case subjects each and that used long-term indoor radon measurements was conducted. Eight studies were available and included a total of 4263 lung cancer case subjects and 6612 control subjects. From the published results of each study, confounder-adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) for categories of radon concentration were obtained, and weighted linear regression analyses were performed. The combined trend in the RR was significantly different from zero (two-sided P = 0.03), and an estimated RR of 1.14 (95% CI = 1.0-1.3) at 150 Bq/m³ was found. An influence analysis indicated that no single study dominated the combined results. The exposure-response trend was similar to model-based extrapolations from underground miners and to RRs computed directly from miners with low cumulative exposures. However there were significant differences in the study-specific estimates of the exposure response (two-sided P &lt;0.001), which were not explained by study differences in percent of the defined exposure interval covered by radon measurements, mean number of residences per subject, and other factors. The results of the meta-analysis indicated that the risk from indoor radon is not likely to be markedly greater than that predicted from miners and that the negative exposure response reported in some ecological studies is likely due to model misspecification or uncontrolled confounding and can be rejected. It is concluded that the studies of underground miners remain the best source of data to use to assess risk from indoor radon.
KW  - buildings
KW  - dwellings
KW  - epidemiology
KW  - human diseases
KW  - lung cancer
KW  - lungs
KW  - miners
KW  - neoplasms
KW  - public health
KW  - radiation
KW  - radon
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancer sites
KW  - cancers
KW  - Human Health and the Environment (VV500) 
KW  - Occupational Health and Safety (VV900) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Extensive latent retroviral infection in bone marrow of patients with HTLV-I-associated neurologic disease.
AU  - Levin, M. C.
AU  - Krichavsky, M.
AU  - Fox, R. J.
AU  - Lehky, T.
AU  - Jacobson, S.
AU  - Fox, C.
AU  - Kleghorn, F.
AU  - White, J.
AU  - Young, N.
AU  - Edwards, R. J.
AU  - Jack, N. E.
AU  - Bartholomew, C.
T2  - Blood
JO  - Blood
JF  - Blood
Y1  - 1997///
VL  - 89
IS  - 1
SP  - 346
EP  - 348
SN  - 0006-4971
AD  - Levin, M. C.: Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurologic Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19972002349.  Publication Type: Correspondence.  Language: English.  Number of References: 12 ref.
KW  - autoimmune diseases
KW  - bone marrow
KW  - clinical aspects
KW  - HTLV infections
KW  - human diseases
KW  - latent infections
KW  - neurology
KW  - Deltaretrovirus
KW  - human t-cell lymphotropic virus type I
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002349&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Birth cohort and calendar period trends in breast cancer mortality in the United States and Canada.
AU  - Tarone, R. E.
AU  - Chu, K. C.
AU  - Gaudette, L. A.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 3
SP  - 251
EP  - 256
SN  - 0027-8874
AD  - Tarone, R. E.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972009446.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Public Health
N2  - Breast cancer mortality rates during 1969-92 for white women and black women in 4 regions of the USA and for all women throughout Canada were compared to identify racial, regional and temporal differences. Differences and trends in the rates were evaluated in view of breast cancer risk factors and relevant medical interventions. Age-period-cohort models were fitted to the data, and changes in birth cohort trends (suggesting a change in a breast cancer risk factor or protective factor) and calendar period trends (suggesting, in part, the impact of new or improved medical interventions) were examined. Breast cancer mortality rates for white women were significantly higher in the North-east than in any other region of the USA (P &lt;0.005); the rates for black women were not. Birth cohort trends for all women were similar until 1940, with a moderation of mortality risk beginning around 1924. A marked moderation of risk by 4-year birth cohorts was observed for US white women born after 1950, whereas stable or slightly decreasing trends were observed for US black women and Canadian women. For women born from 1924 to 1938, fertility rates increased for all 3 groups; after 1950, they declined uniformly. Looking at temporal effects, the slope of the mortality calendar period trend increased in the 1980s compared with the 1970s for all women. In the last calendar period, 1991-92, a trend of decreasing mortality rates was found for white women in the USA and for Canadian women. Possible explanations for these observations are discussed.
KW  - blacks
KW  - breast
KW  - breast cancer
KW  - detection
KW  - diagnosis
KW  - ethnic groups
KW  - fertility
KW  - human diseases
KW  - mortality
KW  - neoplasms
KW  - risk factors
KW  - screening
KW  - therapy
KW  - trends
KW  - women
KW  - Canada
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - breasts
KW  - cancer sites
KW  - cancers
KW  - death rate
KW  - screening tests
KW  - therapeutics
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009446&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication.
AU  - Sloand, E. M.
AU  - Young, N. S.
AU  - Kumar, P.
AU  - Weichold, F. F.
AU  - Sato, T.
AU  - Maciejewski, J. P.
JO  - Blood
JF  - Blood
Y1  - 1997///
VL  - 89
IS  - 4
SP  - 1357
EP  - 1363
SN  - 0006-4971
AD  - Sloand, E. M.: National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Correspondence address: J. P. Maciejewski, University of Nevada, School of Medicine, Department of Microbiology-320, Howard Medical Building, Reno, NV 89557-0046, USA.
N1  - Accession Number: 19972004407.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - Increased Fas-receptor (CD95) expression on CD4+ and CD8+ lymphocytes was seen among 86 HIV-1-infected patients compared with normal blood donor controls; individuals with AIDS and a history of opportunistic infection had significantly more Fas receptor expression than did asymptomatic HIV-infected persons and normal controls. Soluble and membrane-bound forms of Fas ligand were produced in greater amounts by peripheral blood mononuclear cell cultures and in plasma from HIV-1-infected persons than from normal controls. Furthermore, triggering of lymphocytes from HIV-infected persons by the agonistic anti-Fas monoclonal antibody, CH 11, increased levels of interleukin-1β converting enzyme, a protein associated with apoptosis.
KW  - acquired immune deficiency syndrome
KW  - apoptosis
KW  - CD4+ lymphocytes
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - immunology
KW  - immunopathology
KW  - monoclonal antibodies
KW  - pathogenesis
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD4+ cells
KW  - Fas ligand
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004407&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - National Institutes of Health Consensus Development Conference Statement: breast cancer screening for women ages 40-49, January 21-23, 1997.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 14
SP  - 1015
EP  - 1026
SN  - 0027-8874
AD  - Correspondence address: B. Hall, Office of Medical Applications of Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982001718.  Publication Type: Journal Article.  Corporate Author: USA, National Institutes of Health Consensus Development Panel Language: English.  Number of References: 93 ref. Subject Subsets: Public Health
KW  - breast
KW  - breast cancer
KW  - human diseases
KW  - neoplasms
KW  - screening
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - breasts
KW  - cancers
KW  - screening tests
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Health Services (UU350) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001718&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Benzene and the dose-related incidence of hematologic neoplasms in China.
AU  - Hayes, R. B.
AU  - Yin, S. N.
AU  - Dosemeci, M.
AU  - Li, G. N.
AU  - Wacholder, S.
AU  - Travis, L. B.
AU  - Li, C. Y.
AU  - Rothman, N.
AU  - Hoover, R. N.
AU  - Linet, M. S.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 14
SP  - 1065
EP  - 1071
SN  - 0027-8874
AD  - Hayes, R. B.: Division of Cancer Epidemiology and Genetics, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982001719.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 71-43-2.  Subject Subsets: Tropical Diseases
N2  - A cohort of 74 828 benzene-exposed and 35 805 unexposed workers employed during 1972-87 in 12 cities in China was identified and followed to determine the incidence of haematological neoplasms and related disorders. Relative risks (RRs) (ratios of incidence rates for specific haematological neoplasms and related disorders in the benzene-exposed group to incidence rates in the unexposed group) were determined by use of Poisson regression analysis. For workers historically exposed to benzene at mean levels of &lt;10 p.p.m., the RR for all haematological neoplasms combined was 2.2 (95% confidence interval [CI]=1.1-4.2) and, for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes, the RR was 3.2 (95% CI=1.0-4.2), and for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes, the RR was 3.2 (95% CI=1.0-10.1). For individuals who were occupationally exposed to benzene at constant levels of ≥25 p.p.m., the RR for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes was 7.1 (95% CI=2.1-23.7). Workers with 10 or more years of benzene exposure had an RR of developing non-Hodgkin's lymphoma of 4.2 (95% CI=1.1-15.9), and the development of this neoplasm was linked most strongly to exposure that had occurred at least 10 years before diagnosis (distant exposure) (P for trend=0.005, two-sided). In contrast, the risk for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes was significantly increased among those with more recent benzene exposure (P for trend=0.003, two-sided), but it was not linked to distant exposure (P for trend=0.51, two-sided). It is suggested that benzene exposure is associated with a spectrum of haematological neoplasms and related disorders in humans. Risks for these conditions are elevated at mean benzene-exposure levels of &lt;10 p.p.m. and show a tendency to rise with increasing levels of exposure. The temporal pattern of benzene exposure appears to be important in determining the risk of developing specific diseases.
KW  - benzene
KW  - epidemiology
KW  - exposure
KW  - human diseases
KW  - incidence
KW  - leukaemia
KW  - lymphoma
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - risk
KW  - risk factors
KW  - workers
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - blood cancer
KW  - cancers
KW  - leucaemia
KW  - leukemia
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Occupational Health and Safety (VV900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001719&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
AU  - Hildesheim, A.
AU  - Anderson, L. M.
AU  - Chen ChienJen
AU  - Cheng YuJuen
AU  - Brinton, L. A.
AU  - Daly, A. K.
AU  - Reed, C. D.
AU  - Chen IHow
AU  - Caporaso, N. E.
AU  - Hsu MowMing
AU  - Chen JenYang
AU  - Idle, J. R.
AU  - Hoover, R. N.
AU  - Yang CzauSiung
AU  - Chhabra, S. K.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 16
SP  - 1207
EP  - 1212
SN  - 0027-8874
AD  - Hildesheim, A.: National Institutes of Health, Executive Plaza North, Rm 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010479.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Subject Subsets: Tropical Diseases
N2  - A case-control study was conducted to investigate whether variations in the CYP2E1 gene (for cytochrome P450 2E1 enzyme) affect the risk of developing nasopharyngeal cancer. 364 patients with nasopharyngeal carcinoma (96% of 378 eligible patients) and 320 control subjects (86% of 374 eligible subjects) from Taiwan were studied during 1991-94. A risk factor questionnaire was administered to participants to assess factors postulated to be linked to nasopharyngeal carcinoma. Peripheral blood was obtained from all subjects and DNA was purified from nucleated cells. A polymerase chain reaction-based restriction fragment length polymorphism assay that used the restriction enzymes Rsa I and Dra I was used to detect wild-type and variant forms of the CYP2E1 gene. Individuals homozygous for an allele of the CYP2E1 gene that is detected by Rsa I digestion (c2 allele) were found to have an increased risk of nasopharyngeal carcinoma (relative risk (RR)=2.6; 95% confidence interval (CI)=1.2-5.7); this effect was limited to non-smokers (RR=9.3; 95% CI=2.7-32) and was not affected by alcohol consumption. It is suggested that the CYP2E1 genotype is a determinant of nasopharyngeal carcinoma risk.
KW  - carcinoma
KW  - epidemiology
KW  - genes
KW  - human diseases
KW  - nasopharynx
KW  - neoplasms
KW  - patients
KW  - polymorphism
KW  - questionnaires
KW  - restriction fragment length polymorphism
KW  - risk factors
KW  - Taiwan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - South East Asia
KW  - Asia
KW  - cancers
KW  - Formosa
KW  - nasopharyngeal carcinoma
KW  - RFLP
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010479&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Breast implants and cancer.
AU  - Brinton, L. A.
AU  - Brown, S. L.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 18
SP  - 1341
EP  - 1349
SN  - 0027-8874
AD  - Brinton, L. A.: Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19982005844.  Publication Type: Journal Article.  Language: English.  Number of References: 118 ref.
N2  - This general review of studies examines evidence on the long-term safety of silicon and polyurethane foam-covered breast implants. Issues discussed include the interference of implants with breast visualization during mammography (and possible delay in breast cancer diagnosis) and studies concerning implants and incidence of sarcomas, multiple myeloma, lymphomas and other cancers. It is concluded that there is currently little evidence to support the concern that breast implants increase the risk of subsequent breast cancer and there is insufficient data to determine any relationship with predisposition to other cancers.
KW  - breast cancer
KW  - human diseases
KW  - mammary glands
KW  - neoplasms
KW  - prostheses
KW  - reviews
KW  - risk factors
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005844&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark.
AU  - Wideroff, L.
AU  - Gridley, G.
AU  - Mellemkjaer, L.
AU  - Chow, W. H.
AU  - Linet, M.
AU  - Keehn, S.
AU  - Borch-Johnsen, K.
AU  - Olsen, J. H.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 18
SP  - 1360
EP  - 1365
SN  - 0027-8874
AD  - Wideroff, L.: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19982005843.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref.
N2  - Discharge records of 109 581 individuals, hospitalized in Denmark with a diagnosis of diabetes during 1977-89, were linked with national cancer registry records to 1993. Cancer incidence in diabetics during this period was, for males, 4666 and for females, 4165. The standardized incidence ratios (SIRs) for primary liver cancer were 4.0 (95% confidence interval (CI)=3.5-4.6) in males and 2.1 (95% CI=1.6-2.7) in females. These SIRs remained elevated with increasing years of follow-up and after exclusion of patients with reported risk factors (e.g. cirrhosis and hepatitis) or patients whose cancers were diagnosed at autopsy. Kidney cancer risk was elevated, with SIRs of 1.4 (95% CI=1.2-1.6) in males and 1.7 (95% CI=1.4-1.9) in females. For both sexes combined, the SIR for pancreatic cancer was 2.1 (95% CI=1.9-2.4), with a follow-up time of 1-4 years; this SIR declined to 1.3 (95% CI=1.1-1.6) after 5-9 years of follow-up. Excess risks were also observed for biliary tract and endometrial cancers. The SIRs for kidney and endometrial cancers were lower after exclusion of diabetics with reported obesity. Elevated risks of oral/pharyngeal and oesophageal cancers were observed in cohort members entering at age &lt;50 years, which it is suggested may reflect the high preponderance of non-insulin dependent diabetes mellitus in these cohort members. It is concluded that patients hospitalized with a diagnosis of diabetes are at a notably higher risk of developing primary liver cancer.
KW  - diabetes
KW  - diabetes mellitus
KW  - digestive tract
KW  - endometrium
KW  - epidemiology
KW  - females
KW  - incidence
KW  - kidneys
KW  - liver
KW  - liver cancer
KW  - males
KW  - neoplasms
KW  - pancreas
KW  - risk factors
KW  - Denmark
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancers
KW  - endometrial area
KW  - gastrointestinal tract
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005843&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk of second malignant neoplasms among long-term survivors of testicular cancer.
AU  - Travis, L. B.
AU  - Curtis, R. E.
AU  - Storm, H.
AU  - Hall, P.
AU  - Holowaty, E.
AU  - Leeuwen, F. E. van
AU  - Kohler, B. A.
AU  - Pukkala, E.
AU  - Lynch, C. F.
AU  - Andersson, M.
AU  - Bergfeldt, K.
AU  - Clarke, E. A.
AU  - Wiklund, T.
AU  - Stoter, G.
AU  - Gospodarowicz, M.
AU  - Sturgeon, J.
AU  - Fraumeni, J. F., Jr.
AU  - Boice, J. D., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1997///
VL  - 89
IS  - 19
SP  - 1429
EP  - 1439
SN  - 0027-8874
AD  - Travis, L. B.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19982005409.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref.
N2  - A total of 28843 patients diagnosed with a first primary cancer of the testis between 1 January, 1935 and 31 December, 1993 and who survived ≥1 year, were identified within 16 population-based tumour registries in the USA, Canada, Sweden, Finland, Denmark and the Netherlands. 3300 men had survived &gt;20 years. Second cancers were reported in 1406 men (observed-to-expected ratio (O/E)=1.43; 95% confidence interval=1.36-1.51), with significant excesses noted for acute lymphoblastic leukaemia (O/E=5.20), acute nonlymphocytic leukaemia (O/E=3.07), melanoma (O/E=1.69), non-Hodgkin's lymphoma (O/E=1.88) and cancers of the stomach (O/E=1.95), colon (O/E=1.27), rectum (O/E=1.41), pancreas (O/E=2.21), prostate (O/E=1.26), kidney (O/E=1.50), bladder (O/E=2.02), thyroid (O/E=2.92) and connective tissue (O/E=3.16). Overall risk was similar after seminomas (O/E=1.42) or nonseminomatous tumours (O/E=1.50). Risk of solid tumours increased with time since the diagnosis of testicular cancer, yielding an O/E=1.54 (O=369) among 20-year survivors (2-sided P for trend=0.00002). Secondary leukaemia was associated with both radiotherapy and chemotherapy, but excess cancers of the stomach, bladder and possibly, pancreas were associated mainly with radiotherapy. It is concluded that men with testicular cancer continue to be at significantly elevated risk of second malignant neoplasms for over 2 decades following initial diagnosis and that many factors may be involved.
KW  - bladder
KW  - colon
KW  - colorectal cancer
KW  - human diseases
KW  - kidneys
KW  - leukaemia
KW  - lymphoma
KW  - malignant course
KW  - melanoma
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - pancreas
KW  - prostate
KW  - radiotherapy
KW  - rectum
KW  - risk
KW  - stomach
KW  - testes
KW  - thyroid gland
KW  - America
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood cancer
KW  - cancers
KW  - leucaemia
KW  - leukemia
KW  - testicles
KW  - thyroid
KW  - urinary bladder
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005409&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Physical mapping of a defect in Plasmodium falciparum male gametocytogenesis to an 800 kb segment of chromosome 12.
AU  - Guinet, F.
AU  - Wellems, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1997///
VL  - 90
IS  - 1
SP  - 343
EP  - 346
SN  - 0166-6851
AD  - Guinet, F.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980804658.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Protozoology
N2  - Studies on chromosome 12 of the poorly mosquito-infective Dd2 clone of Plasmodium falciparum by pulsed-field gradient electrophoresis showed that the mdv defect did not result from large deletions or rearrangements that would have been detected in the 800 kb chromosome segment at the resolution of the study (20-50 kb). It is suggested that small scale rearrangements or localized mutations that produce changes in the structure and expression of one or more genes may be responsible for the defect.
KW  - chromosome maps
KW  - chromosomes
KW  - gametes
KW  - gametocytes
KW  - gene mapping
KW  - genes
KW  - genetics
KW  - malaria
KW  - mapping
KW  - mutations
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - cartography
KW  - gametocytogenesis
KW  - rearrangements
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804658&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium falciparum Pfs40, renamed Pf39, is localized to an intracellular membrane-bound compartment and is not sexual stage-specific.
AU  - Templeton, T. J.
AU  - Fujioka, H.
AU  - Aikawa, M.
AU  - Parker, K. C.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1997///
VL  - 90
IS  - 1
SP  - 359
EP  - 365
SN  - 0166-6851
AD  - Templeton, T. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980804661.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Subject Subsets: Protozoology
N2  - Studies of the product of the presumed Pfs40 gene of Plasmodium falciparum showed that it is not expressed on the parasite cell surface and is therefore likely to be a protein distinct from the previously described sexual-stage specific 40-kDa cell surface protein. The cloned gene was characterized and defined, and renamed Pf39, as a protein expressed in both sexual and asexual stages. It is localized to an intracellular membranous compartment suggestive of endoplasmic reticulum.
KW  - endoplasmic reticulum
KW  - genes
KW  - molecular genetics
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - Pf39
KW  - Pfs40
KW  - sexual stages
KW  - stage specificity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804661&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Non-ulcerative cutaneous leishmaniasis in Honduras fails to respond to topical paromomycin.
AU  - Neva, F. A.
AU  - Ponce, C.
AU  - Ponce, E.
AU  - Kreutzer, R.
AU  - Modabber, F.
AU  - Olliaro, P.
JO  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF  - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1  - 1997///
VL  - 91
IS  - 4
SP  - 473
EP  - 475
SN  - 0035-9203
AD  - Neva, F. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19980801739.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 7542-37-2.  Subject Subsets: Protozoology; Tropical Diseases
N2  - A double-"blind", placebo-controlled trial of topical therapy with 15% paromomycin and 10% urea in white paraffin was carried out on 53 patients with non-ulcerating cutaneous leishmaniasis in Honduras. Although the treatment was not effective, 18 of 26 isolates at one of the study sites (San Juan Bautista) were found by isoenzyme typing to be Leishmania mexicana. The lesions from which the L. mexicana isolates were recovered were clinically indistinguishable from those caused by L. chagasi [L. infantum chagasi], the aetiologic agent previously found for this form of leishmaniasis. This is the first documented report of L. mexicana in Honduras.
KW  - antiprotozoal agents
KW  - cutaneous leishmaniasis
KW  - drug therapy
KW  - geographical distribution
KW  - human diseases
KW  - leishmaniasis
KW  - lesions
KW  - new geographic records
KW  - parasites
KW  - paromomycin
KW  - pathology
KW  - skin lesions
KW  - Honduras
KW  - Leishmania infantum chagasi
KW  - Leishmania mexicana
KW  - man
KW  - protozoa
KW  - Leishmania infantum
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - CACM
KW  - Central America
KW  - America
KW  - Developing Countries
KW  - Latin America
KW  - aminosidine
KW  - chemotherapy
KW  - leishmaniosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801739&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Complex polymorphisms in an ~330 kDa protein are linked to chloroquine-resistant P. falciparum in southeast Asia and Africa.
AU  - Su XinZhuan
AU  - Kirkman, L. A.
AU  - Fujioka, H.
AU  - Wellems, T. E.
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1997///
VL  - 91
IS  - 5
SP  - 593
EP  - 603
SN  - 0092-8674
AD  - Su XinZhuan: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980803849.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0.  Subject Subsets: Protozoology; Tropical Diseases
N2  - The production of a cross between a Plasmodium falciparum chloroquine sensitive (HB3) and a P. falciparum chloroquine resistant clone (Dd2) provided a genetic approach to study the chloroquine resistance mechanism. Chloroquine resistance in the P. falciparum cross mapped as a Mendelian trait to a 36 kb segment of chromosome 7. This segment harboured cg2, a gene encoding a unique ~330 kDa protein with complex polymorphisms. It is suggested that a specific set of polymorphisms in 20 chloroquine-resistant P. falciparum isolates from Asia and Africa, in contrast with numerous differences in 21 sensitive P. falciparum isolates, indicate selection of a cg2 allele originating in Indochina over 40 years ago. One chloroquine-sensitive clone exhibited this allele, suggesting the occurrence of another resistance component. P. falciparum from South America had cg2 polymorphisms consistent with a separate origin of resistance. The CG2 protein was found at the parasite periphery, a site of chloroquine transport, and in association with haemozoin of the digestive vacuole.
KW  - amino acid sequences
KW  - antimalarials
KW  - antiprotozoal agents
KW  - chloroquine
KW  - chromosomes
KW  - drug resistance
KW  - genes
KW  - genetic polymorphism
KW  - human diseases
KW  - malaria
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - Africa
KW  - Indochina
KW  - South America
KW  - South East Asia
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - South East Asia
KW  - Asia
KW  - America
KW  - biochemical genetics
KW  - DNA sequences
KW  - protein sequences
KW  - Southeast Asia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803849&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum hepatitis G virus RNA in patients with chronic viral hepatitis.
AU  - Marrone, A.
AU  - Shih WaiKuo
AU  - Nakatsuji, Y.
AU  - Alter, H. J.
AU  - Lau, D.
AU  - Vergalla, J.
AU  - Hoofnagle, J. H.
JO  - American Journal of Gastroenterology
JF  - American Journal of Gastroenterology
Y1  - 1997///
VL  - 92
IS  - 11
SP  - 1992
EP  - 1996
SN  - 0002-9270
AD  - Marrone, A.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982005081.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 9008-11-1, 36791-04-5, 63231-63-0.  Subject Subsets: Public Health
N2  - To study the role of hepatitis G virus (HGV) in the course of chronic viral hepatitis, stored serum samples from 108 patients with chronic hepatitis B and 99 patients with chronic hepatitis C who participated in trials (in the USA) of α-interferon or ribavirin between 1984 and 1991 were evaluated for the presence of hepatitis B virus (HBV) DNA and hepatitis C virus (HCV) RNA by branched DNA and for the presence of HGV RNA by polymerase chain reaction (PCR), using primers from the NS5 region of the genome. Initially, 20 (19%) patients with hepatitis B and 11 (11%) with hepatitis C had HGV RNA in their serum. Patients with and without HGV infection were similar with regard to clinical features, laboratory tests and hepatic histology. HGV RNA levels fell during interferon therapy and became undetectable in those receiving the highest doses; however, HGV RNA levels returned to pretreatment values when therapy was stopped. With ribavirin therapy, HGV RNA levels did not change. Two- to 12-year follow-up serum samples were available from 17 initially HGV RNA-positive patients, of whom only 10 (59%) were still positive. It is concluded that HGV infection is common among patients with chronic hepatitis B and C but has little effect on the short-term course of disease or response to therapy. HGV RNA levels are suppressed but not eradicated by α-interferon and are unaffected by ribavirin treatment. Spontaneous loss of HGV RNA occurs over time in a proportion of patients.
KW  - chronic infections
KW  - clinical aspects
KW  - disease course
KW  - drug therapy
KW  - epidemiology
KW  - hepatitis B
KW  - hepatitis C
KW  - human diseases
KW  - infections
KW  - interferon
KW  - liver diseases
KW  - ribavirin
KW  - RNA
KW  - viral diseases
KW  - viral hepatitis
KW  - USA
KW  - Flavivirus
KW  - gb virus c
KW  - hepatitis B virus
KW  - hepatitis C virus
KW  - hepatitis g virus
KW  - man
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - Hepacivirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - clinical picture
KW  - disease progression
KW  - gb virus
KW  - ribonucleic acid
KW  - tribavirin
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005081&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The debate over the effector function of eosinophils in helminth infection: new evidence from studies on the regulation of vaccine immunity by IL-12.
AU  - Wynn, T. A.
A2  - Cordeiro, R.
A2  - Moqbel, R.
A2  - Weller, P. F.
JO  - Memorias do Instituto Oswaldo Cruz, Supplement
JF  - Memorias do Instituto Oswaldo Cruz, Supplement
Y1  - 1997///
VL  - 92
SP  - 105
EP  - 108
AD  - Wynn, T. A.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980805047.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 308067-57-4.  Subject Subsets: Helminthology
N2  - The effects of interleukin (IL)-12 on immunity to schistosomiasis in mice immunized once (1X) or 3 times (3X) with attenuated cercariae of Schistosoma mansoni are reviewed. While multiply-immunized/saline-treated mice demonstrated a 70-80% reduction in parasite burden, 3X/IL-12-vaccinated animals displayed a striking &gt;90% reduction in challenge infection, with many mice demonstrating complete protection. 3X/saline-vaccinated mice produced a mixed Th1/Th2-type cytokine response, while 3X/IL-12 immunized animals displayed a dominant Th1-type response. The animals vaccinated with IL-12 also showed a highly significant increase in total immunoglobulin titres specific for IrV-5, a known protective antigen. 3X/IL-12 serum alone, when transferred to naive mice, reduced worm burdens by over 60% while 3X/saline serum transferred significantly less protection. Nevertheless, animals vaccinated in the presence of IL-12 also developed macrophages with enhanced nitric oxide dependent killing activity against the parasites. These observations suggest that IL-12, initially described as an adjuvant for cell-mediated immunity, may also be used as an adjuvant for promoting both humoral and cell-mediated protective responses.
KW  - adjuvants
KW  - antigens
KW  - cercariae
KW  - cytokines
KW  - experimental infections
KW  - helminths
KW  - immune response
KW  - immunization
KW  - immunoglobulins
KW  - interleukin 12
KW  - laboratory animals
KW  - parasites
KW  - reviews
KW  - schistosomiasis
KW  - T lymphocytes
KW  - vaccines
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - antigenicity
KW  - bilharzia
KW  - bilharziasis
KW  - gamma-globulins
KW  - immune globulins
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805047&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.
AU  - Pantaleo, G.
AU  - Demarest, J. F.
AU  - Schacker, T.
AU  - Vaccarezza, M.
AU  - Cohen, O. J.
AU  - Daucher, M.
AU  - Graziosi, C.
AU  - Schnittman, S. S.
AU  - Quinn, T. C.
AU  - Shaw, G. M.
AU  - Perrin, L.
AU  - Tambussi, G.
AU  - Lazzarin, A.
AU  - Sekaly, R. P.
AU  - Soudeyns, H.
AU  - Corey, L.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 1
SP  - 254
EP  - 258
SN  - 0027-8424
AD  - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972001408.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref.
N2  - Following infection of the host with a virus, the delicate balance between virus replication/spread and the immune response to the virus determines the outcome of infection, i.e., persistence versus elimination of the virus. It is unclear, however, what relative roles immunological and virological factors play during primary viral infection in determining the subsequent clinical outcome. By studying a cohort of subjects with primary HIV infection, it has been demonstrated that qualitative differences in the primary immune response to HIV, but not quantitative differences in the initial levels of viremia are associated with different clinical outcomes. Taken together, these results provide evidence that the initial interaction between the virus and the immune system of the host is an important determining factor in the subsequent clinical outcome, and that immunological factors operative during primary infection, as much as or more thanal virologic factors are critical determinants of the ultimate progression of HIV disease.
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - immunopathology
KW  - pathogenesis
KW  - replication
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001408&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I.
AU  - Brzeska, H.
AU  - Knaus, U. G.
AU  - Wang ZhenYuan
AU  - Bokoch, G. M.
AU  - Korn, E. D.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 4
SP  - 1092
EP  - 1095
SN  - 0027-8424
AD  - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, 9000 Rockville Pike, 3 Center Drive MSC 0301, Bethesda, MD 20892-0301, USA.
N1  - Accession Number: 19970804414.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Protozoology
N2  - The catalytic domain of Acanthamoeba myosin I heavy chain kinase (MIHCK) has extensive sequence similarity to the p21-activated kinase (PAK)/STE20 family of kinases from mammals and yeast, which are activated by small GTP-binding proteins. MIHCK, the 35-kDa catalytic domain of MIHCK (35K), and PAK1 were assayed using 4 different synthetic peptides (PC9, PCJ, PK12, PAK13) as substrates. The concentration of each of the peptide substrates was 0.4 mM and the kinase concentrations were 3.36 µg/ml for MIHCK, 5.36 µg/ml for 35K, and 2.36 µg/ml for PAK. PAK1 had similar substrate specificity to MIHCK exhibiting the highest relative kinase activity with a substrate which had tyrosine residues 2 positions C-terminal to the phosphorylatable serine (PC9). PAK1 also phosphorylated the heavy chain (1 mol of Pi per mol), and activated Acanthamoeba myosin I in a very similar manner to MIHCK. It is concluded that these results, together with the known involvement of Acanthamoeba myosin I, yeast myosin I, STE20, PAK, and small GTP-binding proteins in membrane- and cytoskeleton-associated morphogenetic transformations and activities, suggest that myosins may be physiological substrates for the PAK/STE20 family and thus mediators of these events.
KW  - biochemistry
KW  - kinases
KW  - myosins
KW  - parasites
KW  - Acanthamoeba
KW  - protozoa
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunity to retroviral infection: the Friend virus model.
AU  - Hasenkrug, K. J.
AU  - Chesebro, B.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 15
SP  - 7811
EP  - 7816
SN  - 0027-8424
AD  - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA.
N1  - Accession Number: 19972008317.  Publication Type: Journal Article.  Language: English.  Number of References: 95 ref.
N2  - Friend virus infection of adult immuno-competent mice is a well established model for studying genetic resistance to infection by an immunosuppressive retrovirus. This paper reviews both the genetics of immune resistance and the types of immune responses required for recovery from infection. Specific major histocompatibility complex (MHC) class I and II alleles are necessary for recovery, as is a non-MHC gene, Rfv-3, which controls virus-specific antibody responses. In concordance with these genetic requirements are immunological requirements for cytotoxic T lymphocyte, T helper, and antibody responses, each of which provides essential non-overlapping functions. The complexity of responses necessary for recovery from Friend virus infection has implications for both immunotherapies and vaccines. For example, it is shown that successful passive antibody therapy is dependent on MHC type because of the requirement for T cell responses. For vaccines, successful immunization requires priming of both T cell and B cell responses. In vivo depletion experiments demonstrate different requirements for CD8+ T cells depending on the vaccine used. The implications of these studies for human retroviral diseases are discussed.
KW  - antibodies
KW  - B lymphocytes
KW  - cytotoxicity
KW  - genetics
KW  - immune response
KW  - immunization
KW  - immunology
KW  - major histocompatibility complex
KW  - responses
KW  - reviews
KW  - T lymphocytes
KW  - vaccines
KW  - mice
KW  - retroviridae
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - B cells
KW  - histocompatibility complex
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - MHC antigens
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008317&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for rapid disappearance of initially expanded HIV-1 specific CD8+ T cell clones during primary HIV infection.
AU  - Pantaleo, G.
AU  - Soudeyns, H.
AU  - Demarest, J. F.
AU  - Vaccarezza, M.
AU  - Graziosi, C.
AU  - Paolucci, S.
AU  - Daucher, M. B.
AU  - Cohen, O. J.
AU  - Denis, F.
AU  - Biddison, W. E.
AU  - Sekaly, R. P.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 18
SP  - 9848
EP  - 9853
SN  - 0027-8424
AD  - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.Correspondence address [Pantaleo, G.]: Laboratory of AIDS Immunopathogenesis, Department of Medicine, Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
N1  - Accession Number: 19972008629.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref.
N2  - Down-regulation of the initial burst of viraemia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analysed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance of clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.
KW  - cell mediated immunity
KW  - clones
KW  - cytotoxic T lymphocytes
KW  - cytotoxicity
KW  - epitopes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunology
KW  - lymphocytes
KW  - mutations
KW  - receptors
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - cellular immunity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - primary infections
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008629&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A novel virus in swine is closely related to the human hepatitis E virus.
AU  - Meng XiangJin
AU  - Purcell, R. H.
AU  - Halbur, P. G.
AU  - Lehman, J. R.
AU  - Webb, D. M.
AU  - Tsareva, T. S.
AU  - Haynes, J. S.
AU  - Thacker, B. J.
AU  - Emerson, S. U.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 18
SP  - 9860
EP  - 9865
SN  - 0027-8424
AD  - Meng XiangJin: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0740, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982203589.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2  - A novel virus, designated swine hepatitis E virus (swine HEV), was identified in pigs. Serum samples from pigs in 15 commercial herds in the midwestern USA were tested for HEV using an ELISA. The majority of pigs ≥3 months of age were seropositive. Young pigs naturally infected by swine HEV were clinically healthy but had microscopic evidence of hepatitis, and developed viraemia before seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription-PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79-80% sequence identity at the nucleotide level and 90-92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83-85% nucleotide sequence identity and 77-82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. It is suggested that the discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis.
KW  - amino acid sequences
KW  - ELISA
KW  - hepatitis
KW  - nucleotide sequences
KW  - phylogeny
KW  - zoonoses
KW  - USA
KW  - hepatitis E virus
KW  - man
KW  - pigs
KW  - Hepatitis E-like viruses
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Sus scrofa
KW  - Sus
KW  - Suidae
KW  - Suiformes
KW  - Artiodactyla
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - DNA sequences
KW  - enzyme linked immunosorbent assay
KW  - hogs
KW  - protein sequences
KW  - swine
KW  - United States of America
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982203589&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence.
AU  - Ahlers, J. D.
AU  - Takeshita, T.
AU  - Pendleton, C. D.
AU  - Berzofsky, J. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 20
SP  - 10856
EP  - 10861
SN  - 0027-8424
AD  - Ahlers, J. D.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010620.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
N2  - Viral proteins are not naturally selected for high affinity major histocompatibility complex (MHC) binding sequences; indeed, if there is any selection, it is likely to be negative in nature. Thus, one should be able to increase viral peptide binding to the MHC in the rational design of synthetic peptide vaccines. The T1 helper peptide from the HIV-1 envelope protein was made more immunogenic for inducing T-cell proliferation to the native sequence by replacing a residue that exerts an adverse influence on peptide binding to an MHC class II molecule. Mice immunized with vaccine constructs combining the more potent Th helper (Th) epitope with a cytotoxic T lymphocyte (CTL) determinant developed greatly enhanced CTL responses. Use of class II MHC-congenic mice confirmed that the enhancement of CTL response was due to class II-restricted help. Thus, enhanced T-cell help is key for optimal induction of CTLs, and by modification of the native immunogen to increase binding to the MHC, it is possible to develop second-generation vaccine constructs that enhance both Th cell activation and CTL induction.
KW  - animal models
KW  - antigens
KW  - cells
KW  - cytotoxicity
KW  - envelope proteins
KW  - epitopes
KW  - human diseases
KW  - immune response
KW  - lymphocyte transformation
KW  - lymphocytes
KW  - major histocompatibility complex
KW  - modification
KW  - peptides
KW  - proteins
KW  - T lymphocytes
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - antigenicity
KW  - histocompatibility complex
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunogenicity
KW  - immunogens
KW  - immunological reactions
KW  - T cells
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010620&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.
AU  - Fidock, D. A.
AU  - Wellems, T. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 20
SP  - 10931
EP  - 10936
SN  - 0027-8424
AD  - Fidock, D. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980801874.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 9002-03-3, 59-05-2, 500-92-5.  Subject Subsets: Protozoology
N2  - To investigate suggestions that WR99210 and proguanil act against a target other than the reductase moiety of the Plasmodium falciparum bifunctional dihydrofolate reductase (DHFR)-thymidylate synthase enzyme, P. falciparum was transformed with a variant form of human DHFR selectable by methotrexate. Human DHFR was found to fully negate the antiparasitic effect of WR99210, thus demonstrating that the only significant action of WR99210 is against parasite DHFR. Although the human enzyme also resulted in greater resistance to cycloguanil, no decrease was found in the level of susceptibility of transformed parasites to proguanil, thus providing evidence of intrinsic activity of this parent compound against a target other than DHFR. The transformation system described has the advantage that P. falciparum drug-resistant lines are uniformly sensitive to methotrexate and will complement transformation with existing pyrimethamine-resistance markers in functional studies of P. falciparum genes. This system also provides an approach for screening and identifying novel DHFR inhibitors that will be important in combined chemotherapeutic formulations against malaria.
KW  - antiprotozoal agents
KW  - biochemistry
KW  - dihydrofolate reductase
KW  - drug resistance
KW  - enzymes
KW  - human diseases
KW  - malaria
KW  - methotrexate
KW  - parasites
KW  - proguanil
KW  - transformation
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - amethopterin
KW  - chlorguanide
KW  - chloroguanide
KW  - dihydrofolate reductase-thymidylate synthase
KW  - tetrahydrofolate dehydrogenase
KW  - thymidylate synthase
KW  - WR99210
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801874&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.
AU  - Chun TaeWook
AU  - Stuyver, L.
AU  - Mizell, S. B.
AU  - Ehler, L. A.
AU  - Mican, J. A. M.
AU  - Baseler, M.
AU  - Lloyd, A. L.
AU  - Nowak, M. A.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 24
SP  - 13193
EP  - 13197
SN  - 0027-8424
AD  - Chun TaeWook: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIG, Bldg 10, Rm 6A32, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982001869.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 9007-49-2, 63231-63-0. 
N2  - Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regimens are on latently infected CD4+ T cells and what role these cells play in the persistence of HIV-1 infection in individuals receiving such treatment. The present study demonstrates that highly purified CD4+ T cells from 13 of 13 patients receiving HAART with an average treatment time of 10 months and with undetectable (&lt;500 copies HIV RNA/ml) plasma viraemia by a commonly used bDNA assay carried integrated proviral DNA and were capable of producing infectious virus upon cellular activation in vitro. Phenotypic analysis of HIV-1 produced by activation of latently infected CD4+ T cells revealed the presence in some patients of syncytium-inducing virus. In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viraemia, suggests persistent active virus replication in vivo.
KW  - antiviral agents
KW  - blood plasma
KW  - combination therapy
KW  - DNA
KW  - drugs
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - inhibitors
KW  - latent infections
KW  - patients
KW  - proteinase inhibitors
KW  - proteinases
KW  - regimens
KW  - replication
KW  - RNA
KW  - T lymphocytes
KW  - treatment
KW  - viral load
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - combined modality therapy
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - medicines
KW  - multimodal treatment
KW  - pharmaceuticals
KW  - plasma (blood)
KW  - protease inhibitors
KW  - proteases
KW  - ribonucleic acid
KW  - T cells
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.
AU  - Takemoto, S.
AU  - Mulloy, J. C.
AU  - Ceresto, A.
AU  - Migone, T. S.
AU  - Patel, B. K. R.
AU  - Matsuoka, M.
AU  - Yamaguchi, K.
AU  - Takatsuki, K.
AU  - Kamihira, S.
AU  - White, J. D.
AU  - Leonard, W. J.
AU  - Waldmann, T.
AU  - Franchini, G.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 25
SP  - 13897
EP  - 13902
SN  - 0027-8424
AD  - Takemoto, S.: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, 37 Convent Drive, Bldg. 37, Rm 6A11 Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19982001975.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref.
N2  - These results imply that Janus kinases (JAK) and signal transducer and activators of transcription (STAT) activation is associated with replication of leukaemic cells and that therapeutic approaches aimed at JAK/STAT inhibition may be considered to halt neoplastic growth.
KW  - adult T-cell leukaemia
KW  - inhibition
KW  - kinases
KW  - lymphocyte transformation
KW  - neoplasms
KW  - pathogenesis
KW  - proteins
KW  - replication
KW  - T lymphocytes
KW  - transcription
KW  - transcription factors
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - adult T-cell leukemia
KW  - cancers
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001975&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Asian genotypes of JC virus in native Americans and in a Pacific island population: markers of viral evolution and human migration.
AU  - Agostini, H. T.
AU  - Yanagihara, R.
AU  - Davis, V.
AU  - Ryschkewitsch, C. F.
AU  - Stoner, G. L.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1997///
VL  - 94
IS  - 26
SP  - 14542
EP  - 14546
SN  - 0027-8424
AD  - Agostini, H. T.: Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005893.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
N2  - A total of 68 Navaho from New Mexico,USA, 25 Flathead from Montana, USA, and 29 Chamorro from Guam, in Micronesia were tested for JC virus. Using PCR amplification of a fragment of the VP1 gene, JCV DNA was detected in the urine of 45 (66%) Navaho, 14 (56%) Flathead, and 20 (69%) Chamorro. Genotyping of viral DNAs in these cohorts by cycle sequencing showed predominantly type 2 (Asian), rather than type 1 (European). The large majority (56-89%) of strains excreted by Native Americans and Pacific Islanders were the type 2A subtype, consistent with the origin of these strains in Asia. These findings indicate that JCV infection of Native Americans predates contact with Europeans, and likely predates migration of Amerind ancestors across the Bering land bridge around 12 000-30 000 years ago. If JCV had already differentiated into stable modern genotypes and subtypes prior to first settlement, the origin of JCV in humans may date from 50 000 to 100 000 years ago or more. It is concluded that JCV may have coevolved with the human species, and that it provides a convenient marker for human migrations in both prehistoric and modern times.
KW  - epidemiology
KW  - ethnic groups
KW  - evolution
KW  - genotypes
KW  - human diseases
KW  - migration
KW  - strains
KW  - Guam
KW  - Montana
KW  - New Mexico
KW  - USA
KW  - JC polyomavirus
KW  - man
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Oceania
KW  - Oceania
KW  - Developing Countries
KW  - Mariana Islands
KW  - Micronesia
KW  - Pacific Islands
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Mountain States of USA
KW  - Western States of USA
KW  - Southwestern States of USA
KW  - JC virus
KW  - subtypes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005893&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A simple risk estimates study for oral cavity cancer: practical approach in Indian context.
AU  - Datta, K.
AU  - Saha, R. K.
AU  - Chakrabarti, R. N.
JO  - Journal of the Indian Medical Association
JF  - Journal of the Indian Medical Association
Y1  - 1997///
VL  - 95
IS  - 3
SP  - 70
EP  - 71
SN  - 0019-5847
AD  - Datta, K.: Chittaranjan National Cancer Institute, Calcutta 700026, India.
N1  - Accession Number: 19972008818.  Publication Type: Journal Article.  Language: English.  Number of References: 3 ref. Subject Subsets: Tropical Diseases
N2  - A study was conducted on 131 cases of oral cavity cancer (OCC), 145 cases of oral leukoplakia and a control group of 704 subjects with no oral lesions, to investigate risk factors associated with the development of carcinoma of oral cavity in a hospital based cancer registry in Calcutta, India, during 1990-91. Personal interviews, as well as physical examinations of the subjects enabled evaluation of a variety of potential risk factors. Each potential risk factor such as tobacco chewing, tobacco smoking, snuff dipping, alcohol consumption, bad oral and dental hygiene and age were given certain numerical values. Each subject was first given a scoring and then analysed and correlated with the presenting lesions, if present. Results showed that tobacco chewing and bad oral and dental hygiene contributed mainly to higher scoring. Among the subjects in high risk group (scoring &gt;400) 63% had OCC, 21% had oral leukoplakia and 16% had no clinical oral lesions. Among the medium risk group (scoring 100-400) 6% had OCC, 21% had leukoplakia and 73% had no oral lesions. In low risk group (scoring &lt;100) 8% had leukoplakia and 92% had no clinical oral lesions. Using the scoring system, it is suggested that the high risk group for OCC could be identified from general population and cancer detection tests could be especially directed towards this target group to detect maximum number of cases with minimum possible resources.
KW  - carcinoma
KW  - clinical aspects
KW  - detection
KW  - human diseases
KW  - lesions
KW  - mouth
KW  - neoplasms
KW  - oral cancer
KW  - risk factors
KW  - risk groups
KW  - tobacco
KW  - Asia
KW  - India
KW  - West Bengal
KW  - man
KW  - Nicotiana
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Solanaceae
KW  - Solanales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - cancer sites
KW  - cancers
KW  - clinical picture
KW  - leukoplakia
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008818&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Randomized controlled clinical trials of experimental vaccines.
AU  - Naficy, A. B.
AU  - Clemens, J. D.
AU  - Rao, M. R.
JO  - Bulletin de l'Institut Pasteur
JF  - Bulletin de l'Institut Pasteur
Y1  - 1997///
VL  - 95
IS  - 4
SP  - 187
EP  - 196
AD  - Naficy, A. B.: National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982006040.  Publication Type: Journal Article.  Language: English.  Language of Summary: French.  Number of References: 33 ref.
N2  - Aspects of the design of randomized controlled clinical trials to evaluate the clinical protection conferred by experimental vaccines and to provide further evidence of their safety, as demanded by regulatory agencies before these candidate vaccines can be licensed and introduced into routine public health practice, are discussed.
KW  - clinical aspects
KW  - clinical trials
KW  - experiments
KW  - human diseases
KW  - immunization
KW  - public health
KW  - reviews
KW  - safety
KW  - vaccines
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - immune sensitization
KW  - Health Services (UU350) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Changes in carotenoid intake in the United States: The 1987 and 1992 National Health Interview Surveys.
AU  - Nebeling, L. C.
AU  - Forman, M. R.
AU  - Graubard, B. I.
AU  - Snyder, R. A.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1997///
VL  - 97
IS  - 9
SP  - 991
EP  - 996
SN  - 0002-8223
AD  - Nebeling, L. C.: National Cancer Institute, EPN 211, 6130 Executive Blvd, MSC 7326, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19981414171.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 502-65-8, 127-40-2.  Subject Subsets: Human Nutrition
N2  - A food frequency questionnaire (FFQ) was collected from a representative sample of respondents to the 1987 and 1992 US National Health Interview Surveys throughout 2 calendar quarters. Black and white adults aged 18-69 years, participated in 1987 (n=8161) and 1992 (n=8341). FFQ data were matched and linked to the US Department of Agriculture-National Cancer Institute carotenoid food composition database for analysis. Mean differences in carotenoid intake over time were compared by sociodemographic characteristics and region of the country, after adjustment for sampling weights in a multiple linear regression model. Mean intake of the carotenoid lutein decreased among white women (18%), among adults aged 40-69 years (16%), among persons with 9-12 years of education (11%), among non-drinkers (18%), among drinkers of 1-6 alcoholic drinks/week (7%), among smokers (former smokers by 11%, current smokers by 7% and never smokers by 9%), among income groups (&lt;$20,000 by 7%, ≥$20,000 by 9%) and residents in the south and northeast USA (by 13% each, respectively). Mean intake of the carotenoid lycopene increased among white men (9%), among adults aged 18-39 years and aged 40-69 years (by 5 and 6%, respectively), among those with 13 years of education or more (12.5%), among alcohol drinkers (by 10 and 7% for 1-6 vs. 7 or more drinks/week, respectively), among former and current smokers (by 6% each), among those with incomes ≥$20,000 (8%) and among residents in the west (16%) and midwest (5%). All differences described were significant. It is concluded that the decrease in lutein intake (from dark green leafy vegetables), particularly in white women, may have public health implications as a result of the recognized inverse association between carotenoid intake and disease risk.
KW  - age
KW  - alcoholic beverages
KW  - carotenoids
KW  - diet studies
KW  - education
KW  - ethnicity
KW  - lycopene
KW  - tobacco smoking
KW  - xanthophyll
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - ethnic differences
KW  - lutein
KW  - tetraterpenoids
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414171&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietetics and foodservice personnel are ready for team problem solving.
AU  - Wolf, K. N.
AU  - Schiller, M. R.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1997///
VL  - 97
IS  - 9
SP  - 997
EP  - 1002
SN  - 0002-8223
AD  - Wolf, K. N.: National Cancer Institute, EPN 211, 6130 Executive Blvd, MSC 7326, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19981414172.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Human Nutrition
N2  - 321 dietetics and food service personnel (n=632) in 8 hospitals in Ohio responded to a questionnaire on problem-solving abilities. In general, all respondents were somewhat oriented toward group problem solving and were confident in their problem-solving skills. Problem-solving expertise within the organization decreased for the respondents as the problem moved from their direct work areas to the organization level. Dietitians displayed higher self-efficacy in contributing to problem-solving teams than did food service personnel, indicating a 75% chance that they would contribute whereas all other respondents indicated a 50% chance of contributing. It is concluded that the results of this study generate optimism for involving all dietetics and food service personnel in team problem solving. However, training activities are needed for food service personnel and dietetics professionals.
KW  - dietitians
KW  - hospital catering
KW  - hospital personnel
KW  - hospitals
KW  - skills
KW  - Ohio
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - East North Central States of USA
KW  - hospital food service
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414172&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Total energy expenditure and the level of physical activity correlate with plasma leptin concentrations in five-year-old children.
AU  - Salbe, A. D.
AU  - Nicolson, M.
AU  - Ravussin, E.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1997///
VL  - 99
IS  - 4
SP  - 592
EP  - 595
SN  - 0021-9738
AD  - Salbe, A. D.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016-5319, USA.
N1  - Accession Number: 19971403525.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 169494-85-3.  Subject Subsets: Human Nutrition
N2  - The purpose of this study was to assess the relationship between fasting plasma leptin concentrations and energy expenditure in 5-year-old Pima Indian children (67 males/76 females). Body composition was assessed by isotopic water dilution (18O) whereas total energy expenditure (TEE) and resting metabolic rate (RMR) were measured using doubly labelled water and indirect calorimetry, respectively. The physical activity level was calculated as the ratio of TEE:RMR. Plasma leptin concentrations were positively correlated to percent body fat (r = 0.84, P&lt;0.0001), but were similar in boys and girls after adjusting for percent body fat. Most importantly, it was found that, independent of the percentage of body fat, plasma leptin concentrations correlated with TEE (in absolute values, r = 0.37, P&lt;0.0001) or adjusted for body size (r = 0.42, P&lt;0.0001) and with physical activity level (r = 0.26, P&lt;0.01), but not RMR. These results suggest that, as in animal models, leptin plays a role in energy expenditure in man.
KW  - blood
KW  - body fat
KW  - children
KW  - energy exchange
KW  - energy metabolism
KW  - leptin
KW  - obesity
KW  - physical activity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403525&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - New directions in food allergy research.
AU  - Plaut, M.
JO  - Journal of Allergy and Clinical Immunology
JF  - Journal of Allergy and Clinical Immunology
Y1  - 1997///
VL  - 100
IS  - 1
SP  - 7
EP  - 10
SN  - 0091-6749
AD  - Plaut, M.: Asthma, Allergy and Inflammation Branch, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 4A25, Bethesda, MD 20892-7640, USA.
N1  - Accession Number: 19981407127.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - A synopsis is given of a workshop entitled "New Directions in Food Allergy Research" which took place at the National Institutes of Health, Bethesda, MD, USA from July 29-30, 1996. Topics discussed include the clinical manifestations and natural history of food allergies, molecular characterization of allergens, immune responses in the gastrointestinal tract and new advances in allergy research.
KW  - allergens
KW  - digestive tract
KW  - food allergies
KW  - foods
KW  - immune response
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - food hypersensitivity
KW  - gastrointestinal tract
KW  - immunity reactions
KW  - immunological reactions
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407127&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Safety of a fat-reduced diet: the dietary intervention study in children (DISC).
AU  - Obarzanek, E.
AU  - Hunsberger, S. A.
AU  - Horn, L. van
AU  - Hartmuller, V. V.
AU  - Barton, B. A.
AU  - Stevens, V. J.
AU  - Kwiterovich, P. O.
AU  - Franklin, F. A.
AU  - Kimm, S. Y. S.
AU  - Lasser, N. L.
AU  - Simons-Morton, D. G.
AU  - Lauer, R. M.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1997///
VL  - 100
IS  - 1
SP  - 51
EP  - 59
SN  - 0031-4005
AD  - Obarzanek, E.: National Heart, Lung and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, Maryland, USA.
N1  - Accession Number: 19981415109.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 50-81-7, 7235-40-7, 7440-70-2, 57-88-5, 68-19-9, 9007-73-2, 59-30-3, 7439-95-4, 59-67-6, 7723-14-0, 68-26-8, 83-88-5, 59-43-8, 1406-18-4, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - The relationship between energy intake from fat and anthropometric, biochemical and dietary measures of nutritional adequacy and safety was examined in a 3-year longitudinal study of 663 children (362 boys and 301 girls), 8-10 years old at baseline, with elevated LDL cholesterol, who were participants of the Dietary Intervention Study in Children. Energy intake from fat was assessed from three 24-h recalls at each time point. Lower intake was not related to anthropometric measures or serum Zn, retinol, albumin, β-carotene or vitamin E. Lower fat intake was related to: higher levels of red blood cell folate and haemoglobin, with a trend toward higher serum ferritin; higher intakes of folate, vitamin C and vitamin A, with a trend toward higher iron intake; lower intakes of Ca, Zn, Mg, P, vitamin B12, thiamin, niacin and riboflavin; increased risk of consuming less than two-thirds of the recommended dietary allowances for Ca in girls at baseline, and Zn and vitamin E in boys and girls at all visits. It is concluded that lower fat intakes during puberty are nutritionally adequate for growth and maintenance of normal levels of nutritional biochemical measures, and are associated with beneficial effects on blood folate and haemoglobin. Although lower fat diets were related to lower self-reported intakes of several nutrients, no adverse effects were observed on blood biochemical measures of nutritional status.
KW  - anthropometric dimensions
KW  - ascorbic acid
KW  - beta-carotene
KW  - blood
KW  - boys
KW  - calcium
KW  - children
KW  - cholesterol
KW  - cyanocobalamin
KW  - energy intake
KW  - erythrocytes
KW  - fat
KW  - ferritin
KW  - folic acid
KW  - girls
KW  - growth
KW  - haemoglobin
KW  - hypercholesterolaemia
KW  - hyperlipoproteinaemia
KW  - low density lipoprotein
KW  - magnesium
KW  - minerals
KW  - nicotinic acid
KW  - nutritional state
KW  - phosphorus
KW  - retinol
KW  - riboflavin
KW  - safety
KW  - serum albumin
KW  - sex differences
KW  - thiamin
KW  - trace elements
KW  - vitamin B12
KW  - vitamin E
KW  - vitamins
KW  - zinc
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aneurin
KW  - anthropometric measurements
KW  - axerophthol
KW  - blood red cells
KW  - cobalamin
KW  - folacin
KW  - folate
KW  - hemoglobin
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - hyperlipoproteinemia
KW  - microelements
KW  - niacin
KW  - nutritional status
KW  - red blood cells
KW  - thiamine
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin B1
KW  - vitamin B2
KW  - vitamin C
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.
AU  - Cohen, O. J.
AU  - Vaccarezza, M.
AU  - Lam, G. K.
AU  - Baird, B. F.
AU  - Wildt, K.
AU  - Murphy, P. M.
AU  - Zimmerman, P. A.
AU  - Nutman, T. B.
AU  - Fox, C. H.
AU  - Hoover, S.
AU  - Adelsberger, J.
AU  - Basseler, M.
AU  - Arthos, J.
AU  - Davey, R. T., Jr.
AU  - Dewar, R. L.
AU  - Matcalf, J.
AU  - Schwartzentruber, D. J.
AU  - Orenstein, J. M.
AU  - Buchbinder, S.
AU  - Saah, A. J.
AU  - Detels, R.
AU  - Phair, J.
AU  - Rinaldo, C.
AU  - Margolick, J. B.
AU  - Pantaleo, G.
AU  - Fauci, A. S.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1997///
VL  - 100
IS  - 6
SP  - 1581
EP  - 1589
SN  - 0021-9738
AD  - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, 10 Center Drive MSC 1876, Building 10, Room 11B13, Bethesda, MD 20892-1876, USA.
N1  - Accession Number: 19972010251.  Publication Type: Journal Article.  Language: English.  Number of References: 61 ref.
N2  - HIV-1-infected long-term nonprogressors are a heterogeneous group of individuals with regard to immunological and virological markers of HIV-1 disease. CC chemokine receptor 5 (CCR5) has recently been identified as an important coreceptor for HIV-1 entry into CD4+ T cells. A mutant allele of CCR5 confers a high degree of resistance of HIV-1 infection in homozygous individuals and partial protection against HIV disease progression in heterozygotes. The frequency of CCR5 heterozygotes is increased among HIV-1-infected long-term nonprogressors compared with progressors; however, the host defence mechanisms responsible for nonprogression in CCR5 heterozygotes are unknown. It was hypothesized that nonprogressors who were heterozygous for the mutant CCR5 gene might define a subgroup of nonprogressors with higher CD4+ T-cell counts and lower viral load compared with CCR5 wild-type nonprogressors. However, in a cohort of 33 HIV-1-infected long-term nonprogressors, those who were heterozygous for the mutant CCR5 gene were indistinguishable from CCR5 wild-type nonprogressors with regard to all measured immunological and virological parameters. Although epidemiological data support a role for the mutant CCR5 allele in the determination of the state of long-term nonprogression in some HIV-1-infected individuals, it is not the only determinant. Furthermore, long-term nonprogressors with the wild-type CCR5 genotype are indistinguishable from heterozygotes from an immunological and virological standpoint.
KW  - chemokines
KW  - cytokines
KW  - disease course
KW  - epidemiology
KW  - genotypes
KW  - heterogeneity
KW  - heterozygosity
KW  - HIV-1 infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - leukocyte count
KW  - lymph nodes
KW  - pathogenesis
KW  - phenotypes
KW  - polymorphism
KW  - receptors
KW  - T lymphocytes
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cell count
KW  - disease progression
KW  - human immunodeficiency virus
KW  - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways.
AU  - Blauvelt, A.
AU  - Asada, H.
AU  - Saville, M. W.
AU  - Klaus-Kovtun, V.
AU  - Altman, D. J.
AU  - Yarchoan, R.
AU  - Katz, S. I.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1997///
VL  - 100
IS  - 8
SP  - 2043
EP  - 2053
SN  - 0021-9738
AD  - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Building 10, Room 12N238, 10 Center Drive, MSC 1908, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19982000963.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
N2  - There is substantial evidence that dendritic cells (DCs) residing within epithelial surfaces (e.g., Langerhans cells) are the initial cells infected with HIV after mucosal exposure to virus. To study DC-HIV interactions in detail, Langerhans cell-like DCs were propagated from cord blood CD34+ cells and from adult blood plastic-adherent peripheral blood mononuclear cells in the presence of cytokines (GM-CSF, IL-4, and/or TNF-α). DCs pulsed overnight with HIVBaL or HIVIIIB were infected productively with both viral subtypes (as assessed by PCR, supernatant p24 protein levels, electron microscopy, and antibody staining). Productive infection could be blocked by anti-CD4 monoclonal antibodies, RANTES (regulated upon activation, normal T cell expressed and secreted) (for HIVBaL), stromal cell-derived factor-1 (for HIVIIIB), or azidothymidine added during the HIV pulse, as well as by blocking DC proliferation. However, pulsing DC with HIVs under these blocking conditions had no effect on the ability of DCs to capture virus and transmit infection to cocultured antigen-stimulated CD4+ T cells. Thus, it is shown by several criteria that (a) productive infection of DCs and (b) the ability of DCs to capture virus are mediated through separate pathways. It is suggested that strategies designed to block mucosal transmission of HIV should consider interfering with both virus infection and virus capture by DCs.
KW  - antibodies
KW  - CD4 antigens
KW  - cells
KW  - core protein p24
KW  - cytokines
KW  - dendritic cells
KW  - effects
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunopathology
KW  - infection
KW  - interactions
KW  - mucosa
KW  - pathogenesis
KW  - T lymphocytes
KW  - transmission
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunopathogenesis
KW  - mucous membrane
KW  - p24
KW  - p24 antigen
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food intakes of US children and adolescents compared with recommendations.
AU  - Muñoz, K. A.
AU  - Krebs-Smith, S. M.
AU  - Ballard-Barbash, R.
AU  - Cleveland, L. E.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1997///
VL  - 100
IS  - 3, 1 of 2
SP  - 323
EP  - 329
SN  - 0031-4005
AD  - Muñoz, K. A.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19981415110.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - To determine the proportion of young people meeting national recommendations for food group intake and to identify food intake patterns, data from the USDA's 1989-1991 Continuing Surveys of Food Intakes by Individuals were used to estimate food intake. Intake was determined from 3 days of diet by disaggregating foods into their component ingredients and using weights that corresponded to servings. The sample included 3307 subjects, 2-19 years old, living in the USA. Mean numbers of servings per day were below minimum recommendations for all food groups except the dairy group (ages 2 to 11). Percentages of young people meeting recommendations ranged from 30% for fruit, grain, meat, and dairy to 36% for vegetables. 16% of youth did not meet any recommendations, and 1% met all recommendations. The pattern of meeting all recommendations resulted in nutrient intakes above the recommended dietary allowances and was high in fat. Conversely, meeting none of the recommendations resulted in intakes well below the recommended dietary allowances for some nutrients. Total fat and added sugars averaged 35 and 15% of energy, respectively, and levels were similar among most demographic groups. It is concluded that children and adolescents in the USA follow eating patterns that do not meet national recommendations.
KW  - cereal grains
KW  - children
KW  - diet studies
KW  - fat
KW  - food groups
KW  - food intake
KW  - fruit
KW  - intake
KW  - meat
KW  - milk
KW  - recommended dietary allowances
KW  - sugars
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - RDA
KW  - recommended dietary intakes
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Milk and Dairy Produce (QQ010) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A simple method for measurement of cell-substrate attachment forces: application to HIV-1 Tat.
AU  - Channavajjala, L. S.
AU  - Eidsath, A.
AU  - Saxinger, W. C.
JO  - Journal of Cell Science
JF  - Journal of Cell Science
Y1  - 1997///
VL  - 110
IS  - 2
SP  - 249
EP  - 256
SN  - 0021-9533
AD  - Channavajjala, L. S.: Laboratory of Tumor Cell Biology, NIH/National Cancer Institute, 37 Convent Drive, MSC 4255, Bldg 37, Rm 6B04, Bethesda, MD, USA.
N1  - Accession Number: 19972005032.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref.
N2  - In order to understand the importance of cell attachment to HIV-1 Tat, the strength of cell attachment to immobilized Tat in microtiter plate wells was quantified by the application of buoyant force. By replacing the attachment medium with dense medium, and subjecting the attached cells in the microtiter plates to centrifugal force in the conventional upright position, weakly binding and strongly binding cells could be discriminated (and separated) by varying the centrifugal speed. The strength of attachment of HT1080 cells to Tat was compared with that of the well-known extracellular matrix (ECM) proteins fibronectin and vitronectin. It was observed that all 3 proteins mediated significant attachment of HT1080 cells both at 4°C and 37°C. However, unlike the ECM proteins, Tat was unable to engage in higher strength binding when the temperature was raised to 37°C. The relatively weak binding of HT1080 cells to Tat (in the order of 3.0 µdynes/picomole of coated Tat) and lack of strengthening of binding to Tat at physiological temperature suggests that this protein does not mimic adhesion molecule function. It is anticipated that the methodology developed and described here will be useful in a wide variety of cell-matrix and cell-cell interaction studies.
KW  - adhesion
KW  - application
KW  - cells
KW  - fibronectins
KW  - forces
KW  - HIV-1 infections
KW  - human diseases
KW  - interactions
KW  - measurement
KW  - methodology
KW  - microbiology
KW  - pathogenesis
KW  - proteins
KW  - quantitative techniques
KW  - regulatory genes
KW  - substrates
KW  - tat gene
KW  - Tat protein
KW  - temperature
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - buoyancy
KW  - human immunodeficiency virus type 1
KW  - methods
KW  - metrology
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nonsurgical therapy for pulmonary hydatid cyst disease.
AU  - Mawhorter, S.
AU  - Temeck, B.
AU  - Chang, R.
AU  - Pass, H.
AU  - Nash, T.
JO  - Chest
JF  - Chest
Y1  - 1997///
VL  - 112
IS  - 5
SP  - 1432
EP  - 1436
SN  - 0012-3692
AD  - Mawhorter, S.: Laboratory of Parasitic Diseases, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19980803932.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 54965-21-8.  Subject Subsets: Helminthology; Public Health; Tropical Diseases
N2  - The use of percutaneous drainage and albendazole treatment in a Peruvian patient (who immigrated to the USA in 1985) with a large recurrent, isolated, pulmonary cyst caused by Echinococcus granulosus is described. It is suggested that traditional therapy in this patient would have resulted in severe morbidity. Therapeutic options and possible complications are discussed.
KW  - albendazole
KW  - anthelmintics
KW  - case reports
KW  - echinococcosis
KW  - helminths
KW  - human diseases
KW  - lungs
KW  - medical treatment
KW  - parasites
KW  - therapy
KW  - Peru
KW  - USA
KW  - Echinococcus
KW  - Echinococcus granulosus
KW  - man
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Echinococcus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Andean Group
KW  - APEC countries
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cysts
KW  - hydatid disease
KW  - hydatidosis
KW  - parasitic worms
KW  - therapeutics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803932&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Defects of monocyte interleukin 12 production and humoral immunity in Whipple's disease.
AU  - Marth, T.
AU  - Neurath, M.
AU  - Cuccherini, B. A.
AU  - Strober, W.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1997///
VL  - 113
IS  - 2
SP  - 442
EP  - 448
SN  - 0016-5085
AD  - Marth, T.: Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19982006416.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 308067-57-4.  Subject Subsets: Public Health
N2  - Whipple's disease (WD) is a systemic infection in which the causative bacteria typically accumulate within macrophages. The aim of this study was to test whether this macrophage dysfunction is the cause or result of previously shown T-cell defects. In vitro production of interleukin (IL)-12, IL-10, tumour necrosis factor α, interferon γ (IFN-γ), and transforming growth factor β (TGF-β) from purified monocytes and peripheral blood mononuclear cells (PBMCs); cytokine expression on duodenal biopsy specimens; and serum cytokine and immunoglobulin (Ig) levels were tested in 9 patients with WD. Reduced monocyte IL-12 production and decreased IFN-γ secretion by PBMCs in vitro were found, as well as reduced immunohistological staining for IL-12 and IFN-γ, but no decrease in other cytokines was found in patients with WD. A similar but less severe defect in 2 relatives with WD argued for a genetic basis of this abnormality. Serum IgG2, an IFN-γ-dependent Ig subclass, and serum TGF-β levels were reduced in patients with WD. It is suggested that the described monocyte defects in WD may result in a secondary reduction of IFN-γ production and IgG2 serum levels. This provides a rationale for additive immunotherapy in patients with antibiotic-refractory WD.
KW  - bacterial diseases
KW  - cytokines
KW  - human diseases
KW  - humoral immunity
KW  - immunity
KW  - immunoglobulins
KW  - macrophages
KW  - monocytes
KW  - T lymphocytes
KW  - Whipple's disease
KW  - Germany
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - gamma-globulins
KW  - immune globulins
KW  - T cells
KW  - Tropheryma whippelii
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa.
AU  - Lau, D. T. Y.
AU  - Everhart, J.
AU  - Kleiner, D. E.
AU  - Park, Y.
AU  - Vergalla, J.
AU  - Schmid, P.
AU  - Hoofnagle, J. H.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1997///
VL  - 113
IS  - 5
SP  - 1660
EP  - 1667
SN  - 0016-5085
AD  - Lau, D. T. Y.: Liver Diseases Section, Digestive Diseases Branch, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005090.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9008-11-1.  Subject Subsets: Public Health
N2  - A total of 103 patients with chronic hepatitis B who underwent interferon (IFN)-α therapy in 3 clinical trials, conducted at the National Institutes of Health, Bethesda, MD, USA during 1984-91, were followed up for serological status, biochemical evidence of liver disease, and liver complications or mortality through 1994. 31 patients (30%) responded to therapy, with loss of hepatitis B e antigen (HBeAg) and viral DNA from serum. Responders were more likely than nonresponders to be women, black, and to have more severe liver disease including cirrhosis (P&lt;0.05). Up to 11 years (mean, 6.2 years) after therapy, a higher percentage of responders than nonresponders were still negative for HBeAg (94% vs. 40%; P&lt;0.001) and hepatitis B surface antigen (71% vs. 8.3%; P&lt;0.001). Overall, the rate of liver-related complications and death did not differ by IFN-α response, but with adjustment for cirrhosis, nonresponders had higher rates of liver-related complications and mortality (hazard ratio, 13.7). It is concluded that the response to IFN-α therapy in chronic hepatitis B is usually a sustained improvement in disease markers and, when cirrhosis is considered, patient outcome.
KW  - antigens
KW  - chronic infections
KW  - cirrhosis
KW  - clinical aspects
KW  - complications
KW  - drug therapy
KW  - follow up
KW  - hepatitis B
KW  - human diseases
KW  - interferon
KW  - liver diseases
KW  - mortality
KW  - prognosis
KW  - serology
KW  - viral diseases
KW  - USA
KW  - hepatitis B virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - chemotherapy
KW  - clinical picture
KW  - death rate
KW  - immunogens
KW  - liver cirrhosis
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005090&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut.
AU  - Pimenta, P. F. P.
AU  - Modi, G. B.
AU  - Pereira, S. T.
AU  - Shahabuddin, M.
AU  - Sacks, D. L.
JO  - Parasitology
JF  - Parasitology
Y1  - 1997///
VL  - 115
IS  - 4
SP  - 359
EP  - 369
SN  - 0031-1820
AD  - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980500130.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 103782-08-7, 9001-06-3.  Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - The role of the peritrophic matrix (PM) in the development of Leishmania major infections in Phlebotomus papatasi was investigated by addition of exogenous chitinase to the blood meal, which completely blocked PM formation. Surprisingly, the absence of the PM was associated with the loss of midgut infections. The chitinase was not directly toxic to the parasite, nor were midgut infections lost due to premature expulsion of the blood meal. Most parasites were killed in chitinase-treated flies within the first 4 h after feeding. Substantial early killing was also observed in control flies, suggesting that the lack of PM exacerbates lethal conditions which normally exist in the blood-fed midgut. Early parasite mortality was reversed by soybean trypsin inhibitor. Allosamidin, a specific inhibitor of chitinase, led to a thickening of the PM, and also prevented the early parasite mortality seen in infected flies. Susceptibility to gut proteases was extremely high in transitional-stage parasites, while amastigotes and fully transformed promastigotes were relatively resistant. A novel role for the PM in promoting parasite survival is suggested, in which the PM creates a barrier to the rapid diffusion of digestive enzymes, and limits the exposure of parasites to these enzymes during the time when they are especially vulnerable to proteolytic damage.
KW  - allosamidin
KW  - chitinase
KW  - disease vectors
KW  - host parasite relationships
KW  - hydrolysis
KW  - midgut
KW  - parasites
KW  - peritrophic membrane
KW  - Diptera
KW  - Leishmania major
KW  - Phlebotominae
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Psychodidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator.
AU  - Desai, A.
AU  - Shankar, S. K.
AU  - Jayakumar, P. N.
AU  - Chandramuki, A.
AU  - Gourie-Devi, M.
AU  - Ravikumar, B. V.
AU  - Ravi, V.
JO  - Epidemiology and Infection
JF  - Epidemiology and Infection
Y1  - 1997///
VL  - 118
IS  - 2
SP  - 165
EP  - 171
SN  - 0950-2688
AD  - Desai, A.: Department of Neurovirology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India.
N1  - Accession Number: 19970802266.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - The frequency of cerebral cysticercosis (CC) (Taenia solium metacestode infections) in patients with Japanese encephalitis (JE) was investigated in Bangalore, Karnataka, India, with emphasis on its role in predicting the final clinical outcome. Among 163 confirmed cases of JE, 37.42% (61 of 163) also had CC. This was confirmed by ELISA antibody detection in the cerebrospinal fluid (CSF) of 45 cases, by computed tomography (CT) scan in 6 cases, at autopsy in 3 cases, by CT scan and autopsy in 2 cases, by CSF antibody levels and CT scan in 4 cases, and by CSF antibodies and autopsy in 1 case. The presence of CC was recorded in 24.39% (10 of 41) of the JE cases that recovered, in 39.47% (15 of 38) of the cases that recovered but had neurological problems, and in 53.84% (21 of 39) cases who died. A statistical analysis showed that the coexistence of CC in JE cases indicated a poor outcome.
KW  - brain
KW  - brain diseases
KW  - cerebrospinal fluid
KW  - cestode infections
KW  - cestode larvae
KW  - computed tomography
KW  - concurrent infections
KW  - cysticercosis
KW  - disease prevalence
KW  - ELISA
KW  - helminths
KW  - human diseases
KW  - interactions
KW  - Japanese encephalitis
KW  - metacestodes
KW  - mixed infections
KW  - nervous system diseases
KW  - neurocysticercosis
KW  - parasites
KW  - postmortem examinations
KW  - prognosis
KW  - Asia
KW  - India
KW  - Japanese encephalitis virus
KW  - man
KW  - Taenia solium
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - autopsy
KW  - brain disorders
KW  - cerebrum
KW  - enzyme linked immunosorbent assay
KW  - multiple infections
KW  - neuropathy
KW  - parasitic worms
KW  - pork tapeworm
KW  - postmortem inspections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802266&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons.
AU  - Corti, M. C.
AU  - Guralnik, J. M.
AU  - Salive, M. E.
AU  - Harris, T.
AU  - Ferrucci, L.
AU  - Glynn, R. J.
AU  - Havlik, R. J.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1997///
VL  - 126
IS  - 10
SP  - 753
EP  - 760
SN  - 0003-4819
AD  - Corti, M. C.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA.
N1  - Accession Number: 19981402534.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - A multicentre, longitudinal study with a 5 year follow up to death was carried out to determine whether total cholesterol level is a risk factor for coronary heart disease (CHD) in older adults or inadequate adjustment for co-occurring diseases. 4066 men and women from East Boston, Massachusetts; Iowa and Washington counties, Iowa; and New Haven, Connecticut were included. In 1988, subjects were interviewed about health status and blood samples were taken. Mortality was followed-up to 1992. Analyses included all fatal CHD events (252 deaths) and did not adjust for risk factors for CHD and measures of frailty. Subjects with the lowest total cholesterol levels (≤4.15 mmol/litre) had the highest rate of death from CHD, whereas those with elevated total cholesterol levels (≥6.20 mmol/litre) had a lower risk for death from CHD (P for trend=0.04). After adjustment for established risk factors for CHD and markers of poor health (including chronic conditions, low serum iron and albumin levels) and exclusion of 44 deaths from CHD occurring in the first year, elevated total cholesterol levels predicted increased risk for death from CHD and the risk for death from CHD decreased as cholesterol levels decreased (P for trend =0.005). It is concluded that elevated total cholesterol level is a risk factor for death from CHD in older adults, and the apparent adverse effects associated with low cholesterol levels are secondary to comorbidity and frailty. This suggests that excluding older persons from cholesterol screening is inappropriate, but interpretation of results in older persons requires clinical judgment.
KW  - cardiovascular diseases
KW  - causes of death
KW  - cholesterol
KW  - heart diseases
KW  - hypercholesterolaemia
KW  - hypocholesterolaemia
KW  - mortality
KW  - Connecticut
KW  - Iowa
KW  - Massachusetts
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - West North Central States of USA
KW  - coronary diseases
KW  - death rate
KW  - hypercholesterinemia
KW  - hypercholesterolemia
KW  - hypocholesterolemia
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Crystalluria and urinary tract abnormalities associated with indinavir.
AU  - Kopp, J. B.
AU  - Miller, K. D.
AU  - Mican, J. A. M.
AU  - Feuerstein, I. M.
AU  - Vaughan, E.
AU  - Baker, C.
AU  - Pannell, L. K.
AU  - Falloon, J.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1997///
VL  - 127
IS  - 2
SP  - 119
EP  - 125
SN  - 0003-4819
AD  - Kopp, J. B.: Building 10, Rm 3N116, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972006840.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 150378-17-9. 
N2  - Of 240 patients receiving indinavir, 142 provided urine specimens for analysis. 29 (20%) had crystals consisting of plate-like rectangles and fan-shaped or starburst forms. Mass spectrometry and HPLC confirmed that these crystals were composed of indinavir. Of 40 patients who were not receiving indinavir, none had similar crystals (P&lt;0.001). 19 of the 240 patients receiving indinavir (8%) developed urologic symptoms. Of these, 7 (3%) had nephrolithiasis and the other 12 (5%) had previously undescribed syndromes: crystalluria associated with dysuria and crystalluria associated with back or flank pain. 4 of the patients with the latter syndrome had radiographic evidence of intrarenal sludging. It is concluded that indinavir forms characteristic crystals in the urine. This crystalluria may be associated with dysuria and urinary frequency, with flank or back pain associated with intrarenal sludging, and with the classic syndrome of renal colic.Editorial Comment:This study defines the urinary tract problems associated with the use of Indinavir. These problems affect up to 12% of the patients taking this drug (if you include the patients described in an added 'Note in proof' in this paper). This very interesting article also describes, and shows beautiful photographs of indinavir crystals in the urine; the latest addition to the collection of urine sediments that medical students will have to learn in the future.
KW  - abnormalities
KW  - adverse effects
KW  - antiviral agents
KW  - drug therapy
KW  - HPLC
KW  - human diseases
KW  - indinavir
KW  - kidneys
KW  - patients
KW  - students
KW  - treatment
KW  - urinary tract
KW  - urine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - chemotherapy
KW  - high performance liquid chromatography
KW  - syndromes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Significance of sarcopenia in the elderly.
AU  - Chhanda Dutta
A2  - Beck, M. A. et al.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1997///
VL  - 127
IS  - 5SUPPL
SP  - 992
EP  - 992
SN  - 0022-3166
AD  - Chhanda Dutta: Geriatrics Program, National Institute of Aging, Bethesda, MD 20893, USA.
N1  - Accession Number: 19971408867.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition
N2  - This article briefly reviews the public health effect of sarcopenia and discusses future research possibilities.
KW  - body composition
KW  - losses
KW  - old age
KW  - public health
KW  - reviews
KW  - skeletal muscle
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Society for Nutritional Sciences annual meeting
KW  - sarcopenia
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408867&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - New nonpurified diet (NTP-2000) for rodents in the national toxicology program's toxicology and carcinogenesis studies.
AU  - Rao, G. N.
A2  - Beck, M. A. et al.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1997///
VL  - 127
IS  - 5SUPPL
SP  - 842S
EP  - 846S
SN  - 0022-3166
AD  - Rao, G. N.: National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19971408503.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 22 ref. Registry Number: 7440-70-2, 7723-14-0.  Subject Subsets: Human Nutrition; Animal Nutrition
N2  - This article presents a summary of the results from a series of studies that formulated several experimental diets and used them to examine the influence of dietary protein, fat and fibre on chronic diseases and tumour incidences in rats. Based on the results of the experimental diets, an open-formula non-purified diet designated as NTP-2000 was designed; the formulation and composition of this diet is described. The results of a 13-week study comparing the diets NIH-07 and NTP-2000 are also presented. Generally, the NTP-2000 diet was adequate for growth, did not affect the haematological parameters and did not cause substantial changes in blood chemistry, serum enzyme or serum electrolyte values. The NTP-2000 diet decreased liver and kidney weights, prevented nephrocalcinosis and decreased the severity of diet- and possible age-associated lesions.
KW  - calcium
KW  - carcinogenesis
KW  - composition
KW  - diets
KW  - evaluation
KW  - fat
KW  - fats
KW  - fibre
KW  - growth
KW  - lesions
KW  - minerals
KW  - neoplasms
KW  - phosphorus
KW  - proteins
KW  - toxicology
KW  - rats
KW  - rodents
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ain-2000
KW  - American Society for Nutritional Sciences annual meeting
KW  - cancers
KW  - fiber
KW  - Feed Composition and Quality (RR300) 
KW  - Human Nutrition (General) (VV100) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anthropometry and breast cancer.
AU  - Ziegler, R. G.
A2  - Beck, M. A. et al.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1997///
VL  - 127
IS  - 5SUPPL
SP  - 924S
EP  - 928S
SN  - 0022-3166
AD  - Ziegler, R. G.: Nutritional Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971408659.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 26 ref. Subject Subsets: Human Nutrition
N2  - Studies that examine the relationship between measurements of body size and shape (including height, adiposity, weight change and fat deposition patterns) and breast cancer risk are reviewed.
KW  - abdominal fat
KW  - adipose tissue
KW  - anthropometric dimensions
KW  - body fat
KW  - body weight
KW  - energy balance
KW  - energy intake
KW  - height
KW  - mammary gland neoplasms
KW  - obesity
KW  - physical activity
KW  - reviews
KW  - risk
KW  - weight gain
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Society for Nutritional Sciences annual meeting
KW  - anthropometric measurements
KW  - fatness
KW  - mammary tumour
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408659&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Perspectives on integrating experimental and epidemiologic research on diet, anthropometry and breast cancer.
AU  - Ballard-Barbash, R.
AU  - Birt, D. F.
AU  - Kestin, M.
AU  - King, I. B.
A2  - Beck, M. A. et al.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1997///
VL  - 127
IS  - 5SUPPL
SP  - 936S
EP  - 939S
SN  - 0022-3166
AD  - Ballard-Barbash, R.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971408662.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Three perspectives on the integration of experimental and epidemiological research on diet, anthropometry and breast cancer are presented: integration of basic, clinical and epidemiological research on anthropometry and breast cancer; limitations and synergy of epidemiological and experimental approaches; and controlled dietary interventions and intermediate endpoints. Possible future improvements in animal models are also discussed.
KW  - adipose tissue
KW  - animal experiments
KW  - animal models
KW  - anthropometric dimensions
KW  - body weight
KW  - carcinogenesis
KW  - diet
KW  - dietary fat
KW  - energy intake
KW  - epidemiology
KW  - genetically engineered organisms
KW  - height
KW  - mammary gland neoplasms
KW  - research
KW  - transgenic animals
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Society for Nutritional Sciences annual meeting
KW  - animal research
KW  - anthropometric measurements
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GEOs
KW  - GMOs
KW  - mammary tumour
KW  - source fat
KW  - studies
KW  - transgenic organisms
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408662&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Muscle mass and strength: relation to function in population studies.
AU  - Harris, T.
A2  - Beck, M. A. et al.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1997///
VL  - 127
IS  - 5SUPPL
SP  - 1004S
EP  - 1006S
SN  - 0022-3166
AD  - Harris, T.: National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971408872.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 17 ref. Subject Subsets: Human Nutrition
N2  - This article briefly reviews longitudinal population studies that examined the relationship between sarcopenia and muscle function over time.
KW  - age
KW  - mass
KW  - men
KW  - old age
KW  - reviews
KW  - sex differences
KW  - skeletal muscle
KW  - strength
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - American Society for Nutritional Sciences annual meeting
KW  - Human Nutrition (General) (VV100) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408872&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low levels of physical activity in 5-year-old children.
AU  - Salbe, A. D.
AU  - Fontvieille, A. M.
AU  - Harper, I. T.
AU  - Ravussin, E.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1997///
VL  - 131
IS  - 3
SP  - 423
EP  - 429
SN  - 0022-3476
AD  - Salbe, A. D.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
N1  - Accession Number: 19981401028.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - Physical activity levels were investigated in 43 white and 84 Pima Indian children aged 5 years at the National Institute of Diabetes and Digestive and Kidney Diseases in Phoenix, Arizona and the National Institutes of Health Field Clinic in Sacaton, Arizona, USA, from summer 1991-1995. Pima Indian children (mean age 5.5 years) had significantly higher body weight (23 vs. 19.1 kg), body mass index, relative weight, percentage body fat (30 vs. 21%), fat mass and anthropometric dimensions than white children (mean age 5.4 years). There were no significant differences in total energy expenditure (TEE) and resting metabolic rate (RMR) between the 2 groups. Percentage body fat was negatively correlated with the number of past year recreational activities and parental activity rating. White and Pima Indian children had physical activity levels (TEE/RMR) of 1.35, significantly lower than the WHO recommendation (1.7-2.0) and a TEE value 25% lower than WHO recommendation for dietary intake (67 kcal/kg per day). It is concluded that the cause of obesity in Pima Indian children is most likely due to increased dietary intake, probably in the form of high-fat foods.
KW  - anthropometric dimensions
KW  - body fat
KW  - body weight
KW  - children
KW  - energy exchange
KW  - ethnic groups
KW  - physical activity
KW  - resting energy exchange
KW  - Arizona
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mountain States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southwestern States of USA
KW  - anthropometric measurements
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401028&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A developmental defect in Plasmodium falciparum male gametogenesis.
AU  - Guinet, F.
AU  - Dvorak, J. A.
AU  - Fujioka, H.
AU  - Keister, D. B.
AU  - Muratova, O.
AU  - Kaslow, D. C.
AU  - Aikawa, M.
AU  - Vaidya, A. B.
AU  - Wellems, T. E.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1997///
VL  - 135
IS  - 1
SP  - 269
EP  - 278
SN  - 0021-9525
AD  - Guinet, F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970805868.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Protozoology
N2  - A defect is described that affects the development of competent male gametocytes from a mutant clone of Plasmodium falciparum (Dd2). Comparison of the Dd2 clone with the predecessor clone from which it was derived (W2′82) showed that the defect is a mutation that arose during the long-term cultivation of asexual stages in vitro. Light and electron microscopic images, and indirect immunofluorescence assays with male-specific anti-α-tubulin II antibodies, indicated a global disruption of male development at the gametocyte level, with at least a 70-90% reduction in the proportion of mature male gametocytes by the Dd2 clone relative to W2′82. A high prevalence of abnormal gametocyte forms, frequently containing multiple and unusually large vacuoles, was associated with the defect. It is suggested that the reduced production of mature male gametocytes may reflect a problem in processes that commit a gametocyte to male development or a progressive attrition of viable male gametocytes during maturation. The defect is genetically linked to an almost complete absence of male gamete production and of infectivity to mosquitoes. This is the first sex-specific developmental mutation identified and characterized in Plasmodium.
KW  - clones
KW  - development
KW  - gametocytes
KW  - gametogenesis
KW  - human diseases
KW  - malaria
KW  - mutations
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805868&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Insulin stimulates both leptin secretion and production by rat white adipose tissue.
AU  - Barr, V. A.
AU  - Malide, D.
AU  - Zarnowski, M. J.
AU  - Taylor, S. I.
AU  - Cushman, S. W.
JO  - Endocrinology (Philadelphia)
JF  - Endocrinology (Philadelphia)
Y1  - 1997///
VL  - 138
IS  - 10
SP  - 4463
EP  - 4472
SN  - 0013-7227
AD  - Barr, V. A.: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892-1829, USA.
N1  - Accession Number: 19981404402.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9004-10-8, 169494-85-3.  Subject Subsets: Human Nutrition
KW  - adipocytes
KW  - adipose tissue
KW  - in vitro
KW  - insulin
KW  - leptin
KW  - production
KW  - secretion
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fat cells
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404402&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Five complete genomes of JC virus Type 3 from Africans and African Americans.
AU  - Agostini, H. T.
AU  - Ryschkewitsch, C. F.
AU  - Brubaker, G. R.
AU  - Shao, J.
AU  - Stoner, G. L.
JO  - Archives of Virology
JF  - Archives of Virology
Y1  - 1997///
VL  - 142
IS  - 4
SP  - 637
EP  - 655
SN  - 0304-8608
AD  - Agostini, H. T.: Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-4126, USA.
N1  - Accession Number: 19972006681.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Tropical Diseases
N2  - The complete sequence of 5 human polyomavirus JC virus (JCV) Type 3 strains is reported. The entire JCV genome was polymerase chain reaction amplified from urine specimens of 3 African and 2 African-American individuals. The African consensus sequence was compared with the Type 1 and Type 2 prototype strains, JCV (Mad-1) and JCV(GS/B), respectively. Type 3 differed in 2.2% of its coding region genome from JCV (Mad-1) and in 1.3% from JCV(GS/B). Within the coding region the sequence variation among the 3 types was higher in the capsid protein VP1 and in the regulatory protein large T antigen than in the agnoprotein or in VP2/3. Notable Type 3-specific changes were located at sites adjacent to the zinc finger motif and near the major donor and acceptor splice junctions of large T antigen. Four of the 5 urinary Type 3 strains had an unrearranged, archetypal regulatory region. African strain #309 showed a 10-bp deletion at a location similar to that previously described for #307 from Tanzania. The African-American Type 3 strain #312 was closely related to the African consensus sequence. The complete genome of a urinary JCV strain from another African-American male, previously reported as a possible Type 5, showed a sequence difference of only 0.52% from the Tanzanian consensus and was reclassified as a subtype of Type 3.
KW  - DNA binding motifs
KW  - ethnic groups
KW  - genes
KW  - genomes
KW  - nucleotide sequences
KW  - progressive multifocal leukoencephalopathy
KW  - proteins
KW  - strains
KW  - JC polyomavirus
KW  - man
KW  - Polyomavirus
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - DNA sequences
KW  - jc virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006681&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rabies viruses infect primary cultures of murine, feline, and human microglia and astrocytes.
AU  - Ray, N. B.
AU  - Power, C.
AU  - Lynch, W. P.
AU  - Ewalt, L. C.
AU  - Lodmell, D. L.
JO  - Archives of Virology
JF  - Archives of Virology
Y1  - 1997///
VL  - 142
IS  - 5
SP  - 1011
EP  - 1019
SN  - 0304-8608
AD  - Ray, N. B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth Street, MT 59840, USA.
N1  - Accession Number: 19972209052.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - Primary cultures of murine, feline, and human microglia and astrocytes were infected with different rabies viruses: 2 unpassaged street virus isolates, a cell culture-adapted strain, and a mouse brain-passaged strain. Infection was detected by immunofluorescence in 15 of the 16 (94%) virus-glial cell combinations. Replication of infectious virus, determined by infectivity assay, was detected in 7 of 8 (88%) virus-cell combinations. These results show that astrocytes and microglia can be infected by rabies viruses, suggesting that they may have a role in disease, perhaps contributing to viral spread, persistence and/or neuronal dysfunction.
KW  - cell culture
KW  - immunofluorescence
KW  - nervous system
KW  - viral diseases
KW  - cats
KW  - man
KW  - mice
KW  - rabies virus
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Muridae
KW  - rodents
KW  - Lyssavirus
KW  - Rhabdoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - astrocytes
KW  - fluorescent antibody technique
KW  - IFAT
KW  - microglia
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Tissue and Cell Culture (LL700) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972209052&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intake of Vitamins E, C, and A and risk of lung cancer. The NHANES I Epidemiologic Followup Study.
AU  - Yong LeeChen
AU  - Brown, C. C.
AU  - Schatzkin, A.
AU  - Dresser, C. M.
AU  - Slesinski, M. J.
AU  - Cox, C. S.
AU  - Taylor, P. R.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1997///
VL  - 146
IS  - 3
SP  - 231
EP  - 243
SN  - 0002-9262
AD  - Yong LeeChen: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19971412974.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Registry Number: 68-26-8, 1406-18-4, 50-81-7.  Subject Subsets: Human Nutrition
N2  - The relation between the dietary intake of vitamins E, C, and A (estimated by a 24-h recall) and lung cancer incidence was studied in the First National Health and Nutrition Examination Survey Epidemiologic Followup Study cohort of 3968 men and 6100 women, aged 25-74 years. During a median follow-up period of 19 years (from 1971-1975 to 1992), 248 persons developed lung cancer. Adjusted for potential confounders using Cox proportional hazards regression methods with age as the underlying time variable, the relative risk of lung cancer for subjects in the highest quartile of vitamin C intake compared with those in the lowest quartile was 0.66 (95% confidence interval (CI) 0.45-0.96). For vitamin A intake, a protective effect was observed only for its fruit and vegetable component (carotenoids) among current smokers (relative risk = 0.49, 95% CI 0.29-0.84), but this was modified by the intensity of smoking (a significant effect (relative risk = 0.33, 95% CI 0.13-0.84) was observed only for those in the lowest tertile of pack-years of smoking). The vitamin E intake-lung cancer relation was modified by the intensity of smoking with a significant protective effect confined to current smokers in the lowest tertile of pack-years of smoking (relative risk = 0.36, 95% CI 0.16-0.83). There was no additional protective effect of vitamin E, C, and A supplements beyond that provided through dietary intake. When vitamin E, vitamin C, and carotenoid intakes were examined in combination, a strong protective effect was observed for those in the highest quartile compared with those in the lowest quartile of all 3intakes (relative risk = 0.32, 95% CI 0.14-0.74). These data provide support for a protective role of vitamins E and C and of carotenoids against lung cancer risk but with a modification in effects by the intensity of cigarette exposure. While smoking avoidance is the most important behaviour to reduce lung cancer risk, the daily consumption of a variety of fruits and vegetables that provide a combination of these nutrients and other potential protective factors may offer the best dietary protection against lung cancer.
KW  - ascorbic acid
KW  - carcinogenesis
KW  - carotenoids
KW  - fruit
KW  - intake
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - retinol
KW  - risk
KW  - tobacco smoking
KW  - tocopherols
KW  - vegetables
KW  - vitamin E
KW  - vitamins
KW  - Maryland
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - cancers
KW  - tetraterpenoids
KW  - United States of America
KW  - vegetable crops
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412974&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Insulin and endometrial cancer.
AU  - Troisi, R.
AU  - Paotischman, N.
AU  - Hoover, R. N.
AU  - Siiteri, P.
AU  - Brinton, L. A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1997///
VL  - 146
IS  - 6
SP  - 476
EP  - 482
SN  - 0002-9262
AD  - Troisi, R.: Environmental Epidemiology Branch, National Cancer Institute, EPN Room 443, 6130 Executive Blvd., Bethesda, MD 70892-7374, USA.
N1  - Accession Number: 19972010387.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 59112-80-0, 50-28-2, 53-16-7, 9004-10-8.  Subject Subsets: Human Nutrition; Public Health
N2  - Circulating sex hormones and fasting C-peptide levels were measured in sera obtained from 165 postmenopausal endometrial cancer cases in the USA accrued between 1 June 1987 and 15 May 1990, from hospitals in Chicago, Illinois; Hershey, Pennsylvania; Irvine and Long Beach, California; Minneapolis, Minnesota; and Winston-Salem, North Carolina, and 180 community and hysterectomy controls. Women with a personal history of diabetes were excluded. Among controls, C-peptide was positively correlated with body mass index (BMI) (r = 0.44), waist-to-thigh circumference ratio (r = 0.24), oestrone (r = 0.18), and oestradiol (r = 0.28) (albumin-bound (r = 0.45), and free (r = 0.37)) and negatively correlated with sex hormone-binding globulin (r = -0.48). In age-adjusted analyses, the odds ratios and 95% confidence intervals for tertiles of C-peptide and endometrial cancer were, from lowest to highest: 1.0 (reference), 0.78 (95% confidence interval (CI) 0.43-1.4), and 2.2 (95% CI 1.3-3.7). Further adjustment for BMI substantially attenuated the odds ratios for the highest tertile of C-peptide (odds ratio = 1.2, 95% CI 0.63-2.1), and adjustment for body mass index and other risk factors for endometrial cancer eliminated the association (odds ratio = 1.0, 95% CI 0.55-2.0). In contrast, adjustment for C-peptide had little influence on the magnitude of the positive associations between body mass index (odds ratio for highest vs. lowest tertile, without and with adjustment for C-peptide = 4.1 (95% CI 2.3-7.5) and 3.7 (95% CI 1.9-7.1), respectively) or several steroid hormones and endometrial cancer. These data are not consistent with the hypothesis that the effect of obesity on endometrial cancer risk is mediated through high insulin levels.
KW  - C-peptide
KW  - diabetes
KW  - effects
KW  - endometrial cancer
KW  - estradiol
KW  - estrone
KW  - human diseases
KW  - hyperinsulinism
KW  - insulin
KW  - neoplasms
KW  - obesity
KW  - risk factors
KW  - sex hormones
KW  - steroids
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - fatness
KW  - oestradiol
KW  - oestrol
KW  - oestrone
KW  - proinsulin C-peptide
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010387&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of measurement error on energy-adjustment models in nutritional epidemiology.
AU  - Kipnis, V.
AU  - Freedman, L. S.
AU  - Brown, C. C.
AU  - Hartman, A. M.
AU  - Schatzkin, A.
AU  - Wacholder, S.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1997///
VL  - 146
IS  - 10
SP  - 842
EP  - 855
SN  - 0002-9262
AD  - Kipnis, V.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 344, 6130 Executive Blvd., MSC 7354, Bethesda, MD 20892-7354, USA.
N1  - Accession Number: 19981408254.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition
N2  - Contrary to conventional assumptions invoked in the standard treatment of the effect of measurement error in regression analysis, reporting errors in dietary studies are usually biased, correlated with true nutrient intakes and with each other, heteroscedastic and nonnormally distributed. Methods developed in this paper allow for this more complex error structure and are therefore more appropriate for dietary data. For practical illustration, these methods were applied to data from the Women's Health Trial Vanguard Study. The results demonstrate considerable shrinkage in the magnitude of the estimated main exposure effect in energy-adjustment models due to attenuation of the true effect and contamination from the effect of an adjusting covariate. In most cases, this shrinkage causes a sharply reduced statistical power of the corresponding significance test in comparison with measurement without error. These results emphasize the need to understand the measurement error properties of dietary instruments through validation/calibration studies and, where possible, to correct for the impact of measurement error when applying energy-adjustment models.
KW  - diet study techniques
KW  - energy intake
KW  - epidemiology
KW  - measurement
KW  - models
KW  - nutrition research
KW  - regression analysis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - metrology
KW  - Diet Studies (VV110) 
KW  - Techniques and Methodology (ZZ900) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408254&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Degenerate MHC restriction reveals the contribution of Class I MHC molecules in determining the fine specificity of CTL recognition of an immunodominant determinant of HIV-1 gp160 V3 loop.
AU  - Shirai, M.
AU  - Kozlowski, S.
AU  - Margulies, D. H.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 158
IS  - 7
SP  - 3181
EP  - 3188
SN  - 0022-1767
AD  - Shirai, M.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1578, USA.
N1  - Accession Number: 19972004039.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
N2  - Three class I MHC molecules that are distinct in sequence and serology surprisingly cross-present the same HIV-1 peptide to T cells of each of the other haplotypes. This MHC restriction degeneracy is representative of the bulk of the CTL population with this specificity. Taking advantage of this degeneracy, it was possible to examine the influence that the presenting class I MHC molecule has on the fine specificity of response of a single CTL with a single TCR, as had been done previously for class II-restricted responses in the degenerate cytochrome c system. Reciprocal differences were found that indicate that different class I MHC molecules impose an apparently different fine specificity on the same TCR of a CTL, emphasizing the concerted role of both receptors in the determining the specificity of the CTL recognition event.
KW  - antigens
KW  - envelope protein gp160
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - major histocompatibility complex
KW  - responses
KW  - serology
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - antigenicity
KW  - gp160
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004039&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Borrelia burgdorferi activates nuclear factor-κB and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts.
AU  - Ebnet, K.
AU  - Brown, K. D.
AU  - Siebenlist, U. K.
AU  - Simon, M. M.
AU  - Shaw, S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 158
IS  - 7
SP  - 3285
EP  - 3292
SN  - 0022-1767
AD  - Ebnet, K.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970504484.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 9008-11-1, 142298-00-8.  Subject Subsets: Medical & Veterinary Entomology
N2  - The potential of B. burgdorferi to induce gene expression of chemokines and adhesion molecules in human endothelial cells, keratinocytes and fibroblasts was analysed. Induction of the chemokines RANTES (regulated upon activation, normal T cells expressed and secreted), monocyte chemoattractant protein-1, interleukin-8, gro-α, IFN-inducible protein-10, and mig (monokine induced by γ-IFN), and of the adhesion molecules E-selectin, ICAM-1 and VCAM-1 in endothelial cells and induction of the same chemokines and ICAM-1 in fibroblasts was found. This is mediated by the lipid moiety of the outer surface lipoprotein A. Induction of chemokine and adhesion molecule genes by B. burgdorferi occurs rapidly and does not require new protein synthesis. Induction is blocked by inhibitors of nuclear factor (NF)-κB. Also, B. burgdorferi induces nuclear translocation of NF-κB and a transient increase in the expression of its inhibitor IκB-α. These findings indicate that B. burgdorferi is a potent inducer of molecules required for leukocyte recruitment to inflammatory foci, and the data suggest that this biological activity is due to the ability of the spirochaetes to activate the pleiotropic transcription factor NF-κB.
KW  - cells
KW  - chemokines
KW  - cytokines
KW  - endothelium
KW  - fibroblasts
KW  - gene expression
KW  - human diseases
KW  - immune response
KW  - immunopathology
KW  - inflammation
KW  - interferon
KW  - interleukin 8
KW  - interleukins
KW  - leukocytes
KW  - lipids
KW  - lipoproteins
KW  - Lyme disease
KW  - surface proteins
KW  - T lymphocytes
KW  - Borrelia burgdorferi
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adhesion molecules
KW  - bacterium
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - leucocytes
KW  - lipins
KW  - lyme borreliosis
KW  - membrane proteins
KW  - outer surface proteins
KW  - T cells
KW  - white blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504484&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nuclear factor-κB potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection.
AU  - Moriuchi, H.
AU  - Moriuchi, M.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 158
IS  - 7
SP  - 3483
EP  - 3491
SN  - 0022-1767
AD  - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004040.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 62-38-4. 
N2  - To investigate the molecular mechanisms of RANTES expression, the RANTES promoter region was analysed by transient expression and gel-mobility shift assays. It was demonstrated that: (1) RANTES promoter activity is upregulated by PMA plus ionomycin, coexpression of the p65 subunit of nuclear factor (NF)-κB, the proinflammatory cytokines TNF-α and IL-1β, and the CD28 costimulatory pathway; (2) the RANTES promoter region contains 4 NF-κB binding sites at positions -30, -44, -213 and -579 relative to the transcription start site; (3) one site (-213) is an NF-AT (nuclear factor of activated T cells) binding site that also has weak affinity to NF-κB, and the most distal site (-579) also serves as a CD28-responsive element; and (4) mutation on any of those NF-κB sites of coexpression of IκBα (cytoplasmic inhibitor of NF-κB) markedly reduced the promoter activity. Thus, NF-κB, a potent transcriptional activator of HIV expression, is also involved in the expression of RANTES, a chemokine that blocks infection by macrophage-tropic strains of HIV.
KW  - cytokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - infection
KW  - mutations
KW  - phenylmercury acetate
KW  - promoters
KW  - strains
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - PMA
KW  - promoter region
KW  - promoter sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vaccine-specific antibody responses induced by HIV-1 envelope subunit vaccines.
AU  - Pincus, S. H.
AU  - Messer, K. G.
AU  - Cole, R.
AU  - Ireland, R.
AU  - VanCott, T. C.
AU  - Pinter, A.
AU  - Schwartz, D. H.
AU  - Graham, B. S.
AU  - Gorse, G. J.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 158
IS  - 7
SP  - 3511
EP  - 3520
SN  - 0022-1767
AD  - Pincus, S. H.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19972004042.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
N2  - The first generation of candidate vaccines to prevent HIV infection consisted of recombinant envelope proteins (Env, gp120 and gp160) derived from a single laboratory strain of HIV, designated IIIB/LAV, but produced with different expression systems. This study examined the fine specificity of the human Ab response to each vaccine and compared them to the response of laboratory workers infected with the same strain of HIV. The best responders from each vaccine protocol were studied and compared. Detailed comparisons of the fine specificity of the Ab response were possible because all immunological assays were performed using homologous recombinant proteins, peptides and virus stocks. Although the total amounts of anti-Env Ab were comparable, the groups exhibited significant differences in epitope specificity, avidity and functional capacity of the Ab response. The data demonstrate that the form of the immunogen (e.g., live virus or recombinant protein) is important in determining the quality of the Ab response. Conclusions are also drawn regarding characteristics of there anti-HIV-neutralizing Ab response. These studies represent one of the most detailed analyses of the human Ab response to any Ag and have implications for the development of vaccines for HIV as well as for other microbial pathogens.
KW  - antibodies
KW  - antibody formation
KW  - envelope proteins
KW  - epitopes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - infection
KW  - laboratories
KW  - laboratory workers
KW  - proteins
KW  - responses
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004042&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs.
AU  - Ahlers, J. D.
AU  - Dunlop, N.
AU  - Alling, D. W.
AU  - Nara, P. L.
AU  - Berzofsky, J. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 158
IS  - 8
SP  - 3947
EP  - 3958
SN  - 0022-1767
AD  - Ahlers, J. D.: Correspondence address [Berzofsky, J. A.]: Molecular Immunogenetics and Vaccine Research Section Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004699.  Publication Type: Journal Article.  Language: English.  Number of References: 80 ref. Registry Number: 9007-49-2. 
N2  - The effects were studied of IL-2, IL-4, IL-7, IL-1β, IL-12, IFN-γ, TNF-α and granulocyte-macrophage colony-stimulating factor (GM-CSF) incorporated with peptide in adjuvant on a variety of responses elicited: cytotoxic T lymphocytes, T-cell proliferation, cytokine production and message, and antibody isotype, were investigated. GM-CSF was the single most effective cytokine for enhancing both cellular and humoral immunity to 2 previously characterized HIV-1MN vaccine constructs. Novel synergies were also detected. GM-CSF synergized with IL-12 for CTL induction in BALB/c mice concomitant with suppression of Th2 cytokines IL-4 and IL-10. TNF-α also synergized with IL-12, but by a different mechanism, inducing IFN-γ production in BALB/c mice and thus shifting the response to a Th1 phenotype. The results suggested that in addition to IL-2, optimum induction of CD8+ CTL in vivo requires a combination of cytokines, including GM-CSF (probably acting to enhance Ag presentation and CD4+ cell help), and IL-12 (steering the Th response toward Th1 cytokines). Editorial Comment: This paper explores the ability of several cytokines to augment and steer the immune response in different directions. Several recent papers have explored the use of IL-12 to augment specifically a Th1/CTL response [Tsuji, et al. Journal of Immunology (1997) 158, 4008, 1997]. In this study, Ahlers et al. perform an extensive survey using peptide immunization of mice combined with injection of IL-2, IL-4, IL-7, IL-1β, IL-12, IFN-γ, TNF-α and GM-CSF. GM-CSF was the most useful cytokine for enhancing both antibody and cellular responses. Optimal CTL induction was achieved by using both GM-CSF and IL-12. The authors speculate that GM-CSF enhances antigen presentation and IL-12 steers the CD4 response to a Th1 phenotype. It will be interesting to see these results extended to use in DNA vaccine models.
KW  - adjuvants
KW  - antibodies
KW  - antigens
KW  - CD4 antigens
KW  - cytokines
KW  - DNA
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - humoral immunity
KW  - immune response
KW  - immunity
KW  - immunization
KW  - immunology
KW  - injection
KW  - phenotypes
KW  - production
KW  - responses
KW  - T lymphocytes
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - CD4
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004699&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - FcεRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology.
AU  - Jankovic, D.
AU  - Kullberg, M. C.
AU  - Dombrowicz, D.
AU  - Barbieri, S.
AU  - Caspar, P.
AU  - Wynn, T. A.
AU  - Paul, W. E.
AU  - Cheever, A. W.
AU  - Kinet, J. P.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 159
IS  - 4
SP  - 1868
EP  - 1875
SN  - 0022-1767
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19970804917.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Registry Number: 37341-29-0, 308067-57-4, 207137-56-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - The IgE/FcεRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by FcεRI+ non-B, non-T (NBNT) cells. To evaluate the role of IgE/FcεRI signalling in the host response to helminths, Schistosoma mansoni infection was studied in FcεRI knockout (KO) mice. Infected wild-type (wt) and KO animals showed comparable adult worm and tissue egg burdens, arguing against a role for FcεRI interactions in host resistance. Significantly, NBNT cells from infected KO, in contrast to wt animals, did not secrete IL-4 when stimulated with anti-IgE antibody or soluble parasite antigen. Nevertheless, serum IgE levels and Th2 cytokine production profiles were comparable in both strains of mice, demonstrating that the antigen-dependent stimulation of IL-4 secretion by NBNT cells is not essential for helminth-induced Th2 differentiation. However, when stimulated with low antigen doses, splenocytes from infected FcεRI-deficient mice produced less IL-4 in vitro than similar cultures from infected wt animals, an effect attributable to their defective NBNT cell function. Moreover, infected KO mice showed enhanced egg granuloma formation and hepatic fibrosis, revealing that the IgE/FcεRI interaction, while not essential for Th2 response development or resistance to primary infection, plays a significant role in down-regulating host pathology.
KW  - cytokines
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - immune response
KW  - immunity
KW  - immunoglobulins
KW  - interleukin 4
KW  - laboratory animals
KW  - liver
KW  - parasites
KW  - pathology
KW  - receptors
KW  - schistosomiasis
KW  - t lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bilharzia
KW  - bilharziasis
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - T helper cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804917&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.
AU  - Denkers, E. Y.
AU  - Yap, G.
AU  - Scharton-Kersten, T.
AU  - Charest, H.
AU  - Butcher, B. A.
AU  - Caspar, P.
AU  - Heiny, S.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 159
IS  - 4
SP  - 1903
EP  - 1908
SN  - 0022-1767
AD  - Denkers, E. Y.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980800050.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - Resistance of perforin knockout (PKO) mice to infection with Toxoplasma gondii was assessed in models of acute infection and during chronic disease. PKO mice vaccinated with the attenuated mutant, ts-4, displayed severely defective cytotoxic T lymphocyte (CTL) responses against tachyzoite-infected targets. Lysis of the natural killer (NK) target, YAC-1, was also severely impaired in PKO mice following ts-4 vaccination. In contrast, wild-type mice developed high levels of CTL and NK lytic activity after ts-4 vaccination. Despite severely defective lytic activity, vaccinated PKO animals were completely resistant to challenge with the virulent strain RH, which normally causes a lethal acute infection. Resistance was attributable to production of IFN-γ, which remained unimpaired in the PKO animals. In contrast, when PKO mice were infected with low virulence parasite strain ME49, which progresses to the cyst-forming stage after passage through an acute phase, accelerated mortality was observed beginning at 75 days pi. A 3- to 4-fold increase in brain cyst numbers was also found by day 30 in infected PKO animals. Nevertheless, the PKO strain produced normal levels of IFN-γ after ME49 infection, ruling out impaired production of the latter cytokine as a cause of increased susceptibility. It is concluded that perforin-dependent cytolytic function is not required for host resistance to lethal acute infection in preimmunized animals, but that this activity contributes to the control of infection during the chronic stage.
KW  - acute course
KW  - chronic course
KW  - cytokines
KW  - cytolysis
KW  - cytotoxic T lymphocytes
KW  - disease resistance
KW  - experimental infections
KW  - immune response
KW  - interferon
KW  - laboratory animals
KW  - mortality
KW  - natural killer cells
KW  - parasites
KW  - tachyzoites
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - death rate
KW  - immunity reactions
KW  - immunological reactions
KW  - perforin
KW  - resistance to disease
KW  - severe course
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase.
AU  - Biddison, W. E.
AU  - Kubota, R.
AU  - Kawanishi, T.
AU  - Taub, D. D.
AU  - Cruikshank, W. W.
AU  - Center, D. M.
AU  - Connor, E. W.
AU  - Utz, U.
AU  - Jacobson, S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 159
IS  - 4
SP  - 2018
EP  - 2025
SN  - 0022-1767
AD  - Biddison, W. E.: Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10/Room 5B-16, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972008271.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref.
N2  - In this study, it was demonstrated that HAM/TSP patients have elevated levels of IFN-γ-producing CD8+ T cells in their peripheral blood, and a panel of HTLV-I peptide specific CD8+ CTL clones isolated from the peripheral blood of 3 HAM/TSP patients were analyzed for their capacity to secrete the pro-inflammatory mediators IFN-γ, TNF-α, MIP-1β, IL-16, and matrix metalloproteinases.
KW  - CD4+ lymphocytes
KW  - CD8+ lymphocytes
KW  - chemokines
KW  - cytokines
KW  - human diseases
KW  - immunology
KW  - T lymphocytes
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4+ cells
KW  - CD8+ cells
KW  - HTLV-BLV group
KW  - peripheral blood
KW  - T cells
KW  - T4 lymphocytes
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008271&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120.
AU  - Jankovic, D.
AU  - Caspar, P.
AU  - Zweig, M.
AU  - Garcia-Moll, M.
AU  - Showalter, S. D.
AU  - Vogel, F. R.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 159
IS  - 5
SP  - 2409
EP  - 2417
SN  - 0022-1767
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 4/126, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19972009693.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - In the present study the use of IL-12 was evaluated as an adjuvant for promoting both humoral and cell-mediated immunity to recombinant HIV-1 gp120, a molecule previously shown to be weakly immunogenic in mice in the absence of adjuvant. HIV envelope glycoproteins are under consideration as a component of candidate vaccines for preventing AIDS and can serve as targets for both antibody- and CTL-dependent effector mechanisms. It is shown here that IL-12 can serve as an effective adjuvant for simultaneously enhancing both humoral and type 1 cytokine responses to gp120. It appears, however, that optimal immunization in this situation depends on the route of administration of IL-12 as well as the combined formulation of the cytokine and antigen with alum. The IL-12 vaccination protocol described may have general applicability in boosting responses to weakly immunogenic protein antigen.
KW  - acquired immune deficiency syndrome
KW  - adjuvants
KW  - antibodies
KW  - antigens
KW  - cell mediated immunity
KW  - cytokines
KW  - envelope glycoproteins
KW  - glycoproteins
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - humoral immunity
KW  - immune response
KW  - immunity
KW  - immunization
KW  - immunogenetics
KW  - immunology
KW  - interleukin 12
KW  - interleukins
KW  - responses
KW  - vaccination
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - antigenicity
KW  - cellular immunity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of parasite antigen-specific antibody responses in unsensitized human B cells is dependent on the presence of cytokines after T cell priming.
AU  - Garraud, O.
AU  - Perler, F. B.
AU  - Bradley, J. E.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 159
IS  - 10
SP  - 4793
EP  - 4798
SN  - 0022-1767
AD  - Garraud, O.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20850, USA.
N1  - Accession Number: 19980802434.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2.  Subject Subsets: Helminthology
N2  - Using 2 recombinant filarial protein antigens (Ov27 and OvD5B, from Onchocerca volvulus) and keyhole limpet haemocyanin, T cells from uninfected, nonatopic humans were sensitized in such a manner that they were able to provide help for the selective induction of an antigen-specific antibody response; interleukins 2 and 4 (IL-2 and IL-4) were shown to be critical for sensitizing the T cells. Once sensitized, these T cells could provide the necessary signals for B cells to produce antigen-specific antibodies on exposure to the antigens, provided that IL-4 (or in some experiments IL-2) was supplied exogenously. Primary exposure of T cells to IFN-γ, but not exposure to IL-12, prevented the antigen-sensitized T cells from helping B cells to produce specific antibodies, apart from the IgG2 isotype. These data suggest that antibody-producing B cells of a defined antigen specificity and isotype can be generated differentially after in vitro priming of human T cells by antigens, provided regulatory cytokines are also present.
KW  - antigens
KW  - B lymphocytes
KW  - cytokines
KW  - haemocyanins
KW  - helminths
KW  - immune response
KW  - in vitro
KW  - induction
KW  - interferon
KW  - interleukin 2
KW  - interleukin 4
KW  - interleukins
KW  - parasites
KW  - recombinant antigens
KW  - T lymphocytes
KW  - man
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - B cells
KW  - hemocyanins
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry.
AU  - Moriuchi, H.
AU  - Mouiuchi , M.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1997///
VL  - 159
IS  - 11
SP  - 5441
EP  - 5449
SN  - 0022-1767
AD  - Moriuchi, H.: National Institutes of Health, Bldg 10, Rm 6A11, 10 Center Drive, MSC-1576, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982000414.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 9003-98-9, 9007-49-2. 
N2  - The chemokine receptor CCR5 is a cofactor for cellular entry of macrophage-tropic strains of HIV-1. Expression of CCR5 is restricted to T cells, macrophages, and certain cell lines; however, the mechanisms controlling its expression remain largely unknown. To delineate these mechanisms, approximately 1.0 kb of DNA from the immediate 5′ upstream region of CCR5 was cloned and characterized. CCR5 promoter activity was up-regulated by PMA, and a region spanning -417 to +61 relative to the transcription start site was sufficient for the basal and induced activity. DNase [deoxyribonuclease] I footprinting assays demonstrated several protected areas within this region, and gel shift assays determined binding sites for transcriptional factors Oct-1, Oct-2, T cell factor 1α, and GATA1. CCR5 promoter activity was also induced by IL-2 or anti-CD3 Ab, while stimulation with anti-CD28 Ab markedly reduced CD3-mediated up-regulation of the CCR5 promoter. Flow cytometry confirmed the findings at the level of cell surface expression.
KW  - clones
KW  - cofactors
KW  - deoxyribonuclease I
KW  - DNA
KW  - flow cytometry
KW  - promoters
KW  - stimulation
KW  - strains
KW  - T lymphocytes
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cell surface proteins
KW  - deoxyribonuclease
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - DNASE
KW  - human immunodeficiency virus type 1
KW  - mechanisms
KW  - promoter region
KW  - promoter sequences
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Symptomatic appendiceal wall thickening in an HIV-infected patient cause by interleukin-2 therapy.
AU  - Avila, N. A.
AU  - Dwyer, A. J.
AU  - Falloon, J.
JO  - American Journal of Roentgenology
JF  - American Journal of Roentgenology
Y1  - 1997///
VL  - 169
IS  - 2
SP  - 499
EP  - 500
SN  - 0361-803X
AD  - Avila, N. A.: Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg. 10, Rm 1C-660, 10 Center Dr., MSC 1182, Bethesda, MD 20892-1182, USA.
N1  - Accession Number: 19972009678.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Registry Number: 102524-44-7, 85898-30-2. 
KW  - adverse effects
KW  - case reports
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunomodulators
KW  - interleukin 2
KW  - interleukins
KW  - symptoms
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009678&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons.
AU  - Davey, R. T., Jr.
AU  - Chaitt, D. G.
AU  - Piscitelli, S. C.
AU  - Wells, M.
AU  - Kovacs, J. A.
AU  - Walker, R. E.
AU  - Falloon, J.
AU  - Polis, M. A.
AU  - Metcalf, J. A.
AU  - Masur, H.
AU  - Fyfe, G.
AU  - Lane, H. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 175
IS  - 4
SP  - 781
EP  - 789
SN  - 0022-1899
AD  - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Room 11C103, Bethesda, MD 20892-1880, USA.
N1  - Accession Number: 19972004509.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 102524-44-7, 85898-30-2. 
N2  - The safety and efficacy were assessed of 5-day cycles of subcutaneous (sc) interleukin-2 (IL-2) every 8 weeks in HIV-1-infected outpatients with ≥200 CD4+ cells/µl. Immunological, virological, and toxicity parameters were measured in 18 patients receiving standard antiretrovirals plus 5-day courses of sc IL-2 (3-18 MIU/day) every 2 months. Systemic toxicities established the maximally tolerated dose (MTD) of IL-2 as 15 MIU/day. CD4+ cell responses appeared to correlate directly with baseline CD4+ cell counts, with several patients experiencing a dramatic rise after 3 cycles. Virus load increased only transiently in the peri-injection period. It was concluded that serial cycles of outpatient sc IL-2 can be administered safely, with an MTD of 15 MIU/day. Patients with higher baseline counts appear to have a greater CD4+ cell response to sc IL-2 therapy.Editorial Comment:IL-2 increases significantly the CD4+ cell count of patients with HIV infection at the cost of a significant toxicity. This article shows that the subcutaneous route is better tolerated than the intravenous. There is an ongoing ACTG trial (ACTG 328) that is comparing two i.v. high dose regimens and highly active antiretroviral therapy (HAART) with HAART alone, that will help define the role of high dose IL-2 as adjuvant therapy in HIV infection.
KW  - adjuvants
KW  - antiviral agents
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunomodulators
KW  - immunotherapy
KW  - infection
KW  - interleukin 2
KW  - interleukins
KW  - leukocyte count
KW  - patients
KW  - regimens
KW  - safety
KW  - subcutaneous injection
KW  - toxicity
KW  - treatment
KW  - viral load
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - outpatients
KW  - T4 lymphocytes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Occupational Health and Safety (VV900) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - The relationship between serum human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1 infected children.
AU  - Mofenson, L. M.
AU  - Korelitz, J.
AU  - Meyer, W. A., III
AU  - Bethel, J.
AU  - Rich, K.
AU  - Pahwa, S.
AU  - Moye, J., Jr.
AU  - Nugent, R.
AU  - Read, J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 175
IS  - 5
SP  - 1029
EP  - 1038
SN  - 0022-1899
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19972004727.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 308067-57-4, 63231-63-0. 
N2  - Association of HIV-1 RNA level, CD4+ cell percentage and mortality was examined in stored sera from 254 infected children in an intravenous immunoglobulin infection prophylaxis trial. 92 children (36.2%) died (41 during the study, 51 during long-term follow-up). The geometric mean baseline HIV-1 RNA level was 104 636 copies/ml and the mean CD4+ cell percentage was 25%. Relative risk of death (RR) was 2.1 if the baseline RNA level was &gt;100 000 copies/ml (95% CI, 2.2-4.0). If RNA levels increased after baseline, the RR was 1.8 (95% CI, 1.3-2.6) and if the CD4+ cell percentage dropped to &lt;15%, the RR was 2.8 (95% CI, 1.6-4.9). In a multivariate model, both baseline RNA level and CD4+ cell percentage were independently associated with mortality risk. In a time-dependent model, the RR per log10 increase in HIV-1 RNA copy numbers were 2.8 (95% CI, 2.1-3.6) and per 5 percentage point decrement in CD4+ cell percentage was 1.3 (95% CI, 1.2-1.5). Both variables should be considered in decision-making regarding therapy and evaluation of antiretroviral response.
KW  - antiviral agents
KW  - CD4 antigens
KW  - children
KW  - clinical aspects
KW  - death
KW  - disease course
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunoglobulins
KW  - infection
KW  - lymphocytes
KW  - mortality
KW  - relationships
KW  - RNA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - clinical picture
KW  - death rate
KW  - disease progression
KW  - gamma-globulins
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immune globulins
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of serum antibodies to a Kaposi's sarcoma-associated herpesvirus-specific peptide.
AU  - Davis, D. A.
AU  - Humphrey, R. W.
AU  - Newcomb, F. M.
AU  - O'Brien, T. R.
AU  - Goedert, J. J.
AU  - Straus, S. E.
AU  - Yarchoan, R.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 175
IS  - 5
SP  - 1071
EP  - 1079
SN  - 0022-1899
AD  - Davis, D. A.: Correspondence address [Yarchoan, R.]: National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004732.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref.
N2  - In an attempt to assess KSHV/HHV-8 infection, an ELISA was developed using an 18-amino acid peptide from a putative minor capsid protein of KSHV/HHV-8 conjugated to bovine serum albumin. Overall, sera from HIV-1 positive patients with KS had a higher reactivity in the assay than did sera from HIV-1 positive patients without KS (P=0.018). Of 35 HIV-1-positive patients with KS, 60% were antibody positive, compared with 27% of 33 HIV-1-positive patients without KS. Of 30 healthy blood donors, 20% were antibody positive. The ELISA responses did not correlate with antibody titres to Epstein-Barr virus. Given the homology and antigenic relatedness between KSHV/HHV-8 and Epstein-Barr virus, serological assays involving unique KSHV/HHV-8 peptides may prove to be valuable in defining the epidemiology and clinical expression of this virus.
KW  - antibodies
KW  - blood serum
KW  - clinical aspects
KW  - ELISA
KW  - epidemiology
KW  - human diseases
KW  - human herpesviruses
KW  - immunology
KW  - infections
KW  - patients
KW  - peptides
KW  - responses
KW  - serology
KW  - Human herpesvirus 4
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - clinical picture
KW  - enzyme linked immunosorbent assay
KW  - epstein-barr virus
KW  - human herpesvirus
KW  - human immunodeficiency virus type 1
KW  - other microorganisms
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Influence of other maternal variables on the relationship between maternal virus load and mother-to-infant transmission of human immunodeficiency virus type 1.
AU  - Burns, D. N.
AU  - Landesman, S.
AU  - Wright, D. J.
AU  - Waters, D.
AU  - Mitchell, R. M.
AU  - Rubinstein, A.
AU  - Willoughby, A.
AU  - Goedert, J. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 175
IS  - 5
SP  - 1206
EP  - 1210
SN  - 0022-1899
AD  - Burns, D. N.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 4B11, Rockville, MD 20892-7510, USA.
N1  - Accession Number: 19972004736.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 63231-63-0. 
N2  - To assess the relationship between HIV-1 RNA level, other important covariates, and mother-to-infant (vertical) transmission of HIV-1, third trimester repository specimens from 160 HIV-1-seropositive women enrolled in the Mothers and Infants Cohort Study during 1986-91 were assayed in batch for HIV-1 RNA. A significant association between peripheral blood HIV-1 RNA level and vertical transmission remained after controlling for CD4+ cell level, duration of ruptured membranes, "hard" drug (cocaine and heroin) use, and frequency of sexual activity during pregnancy. However, the association was attenuated among women with advanced HIV infection and those with a high frequency of sexual activity during pregnancy. In these settings, interventions that target risk factors other than virus load may be particularly important for preventing vertical transmission of HIV-1.
KW  - disease transmission
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - infection
KW  - maternal transmission
KW  - mothers
KW  - risk factors
KW  - RNA
KW  - transmission
KW  - women
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - JC virus (JCV) genotypes in brain tissue from patients with progressive multifocal leukoencephalopathy (PML) and in urine from controls without PML: increased frequency of JCV type 2 in PML.
AU  - Agostini, H. T.
AU  - Ryschkewitsch, C. F.
AU  - Mory, R.
AU  - Singer, E. J.
AU  - Stoner, G. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 176
IS  - 1
SP  - 1
EP  - 8
SN  - 0022-1899
AD  - Agostini, H. T.: Correspondence address [Stoner, G. L.]: Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20892-4126, USA.
N1  - Accession Number: 19972005929.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 59865-13-3, 9007-49-2. 
N2  - In this study, the control group consisted of 213 persons not infected with HIV-1 and 32 HIV-infected persons. JCV excretion in HIV-positive individuals confirmed that JCV DNA can be detected in &gt;40% of single urine samples from persons aged &gt;30 years. HIV-1 infection did not appear to increase the overall frequency of JCV excretion. This agrees with previously published results in which neither HIV-positive patients with low CD4+ lymphocyte counts nor multiple sclerosis patients treated with cyclosporin showed an increased frequency of JC viruria compared with immunocompetent controls. 67 probands were tested more than once for JCV excretion in their urine, and in most, the excretion status was stable. 12 persons had transient viruria, indicating that JCV excretion can be variable. It may therefore be useful to test serial samples in order to increase the probability of identifying the JCV genotype carried by a particular individual. Editorial comment:This interesting small study suggests that there may be differences in the strain of JC virus that causes PML. This might explain why there is a large number of individuals who shed JC in their urine but do not develop PML. This hypothesis should be explored further in a larger population.
KW  - body parts
KW  - brain
KW  - ciclosporin
KW  - clinical aspects
KW  - controls
KW  - DNA
KW  - encephalopathy
KW  - genotypes
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune competence
KW  - infection
KW  - lymphocytes
KW  - multiple sclerosis
KW  - nervous system
KW  - patients
KW  - progressive multifocal leukoencephalopathy
KW  - samples
KW  - urine
KW  - Human immunodeficiency virus 1
KW  - JC polyomavirus
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - clinical picture
KW  - cyclosporin
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunocompetence
KW  - immunological competence
KW  - jc virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005929&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killing.
AU  - Shibata, R.
AU  - Maldarelli, F.
AU  - Siemon, C.
AU  - Matano, T.
AU  - Parta, M.
AU  - Miller, G.
AU  - Fredrickson, T.
AU  - Martin, M. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 176
IS  - 2
SP  - 362
EP  - 373
SN  - 0022-1899
AD  - Shibata, R.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg. 4, Rm 305, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19972006927.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref.
N2  - Chimeric simian-HIV (SHIVs) carrying envelope glycoproteins derived from a T cell-macrophage dual-tropic primary isolate HIV-1 strain DH12 were constructed. When inoculated into macaque monkeys, SHIVMD14 carrying SIV-derived nef established significantly higher virus loads than did SHIVMD1, which contained the HIV-1 nef gene. Three patterns of CD4 cell depletion were observed in infected monkeys: exponential and irreversible loss to undetectable levels within 10 weeks of infection; marked reduction during acute infection followed by partial recovery and stabilization (lasting from 10 weeks to &gt;1 year), with later decline to undetectable levels in some animals; and a transient loss during acute infection. The induced immunodeficiency was accompanied by CD4 cell counts of &lt;50 cells/µl and was associated with Pneumocystis carinii pneumonia, cytomegalovirus meningoencephalitis, lymphoid depletion, and thymic atrophy.
KW  - acute infections
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - depletion
KW  - envelope glycoproteins
KW  - glycoproteins
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - leukocyte count
KW  - microbiology
KW  - pathogenesis
KW  - pathogenicity
KW  - Cytomegalovirus
KW  - Human immunodeficiency virus 1
KW  - Macaca
KW  - monkeys
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - human immunodeficiency viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - severe infections
KW  - T4 lymphocytes
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006927&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Summary of antibody workshop: the role of humoral immunity in the treatment and prevention of emerging and extant infectious diseases.
AU  - Krause, R. M.
AU  - Dimmock, N. J.
AU  - Morens, D. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 176
IS  - 3
SP  - 549
EP  - 559
SN  - 0022-1899
AD  - Krause, R. M.: Fogarty International Center, Bldg. 16, Rm 202B, 16 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972008597.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 72 ref.
N2  - The role of humoral immunity in treatment and prevention was the focus of discussion at a 1966 workshop entitled, "The Role of Humoral Immunity in the Treatment and Prevention of Infectious Diseases: The In Vitro and In Vivo Processes Initiated by Antibodies that Neutralize and Destroy Infectious Agents". The cellular and molecular mechanisms of neutralization were examined in detail. It was noted that success in passive immunity has frequently been the key element in devising a successful strategy to develop a vaccine for active immunization. The workshop concluded on a cautious note of optimism that antibody-based treatment and prevention for diseases such as HIV infection, Ebola fever, and others of clinical and public health importance deserve further development and clinical trial.
KW  - antibodies
KW  - clinical aspects
KW  - human immunodeficiency viruses
KW  - humoral immunity
KW  - immunity
KW  - immunology
KW  - public health
KW  - treatment
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - strategies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Health Services (UU350) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008597&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - International colloquium on ebola virus research: summary report.
AU  - Breman, J. G.
AU  - Groen, G. van der
AU  - Peters, C. J.
AU  - Heymann, D. L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 176
IS  - 4
SP  - 1058
EP  - 1063
SN  - 0022-1899
AD  - Breman, J. G.: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010637.  Publication Type: Journal Article; Annual report; Conference paper; Journal article.  Language: English.  Number of References: 43 ref. Subject Subsets: Tropical Diseases
N2  - The International Colloquium on Ebola Virus Research was held at the Institute of Tropical Medicine (ITM), Antwerp, Belgium, 4-7 September 1996. The meeting was co-organized by the ITM and the National Institutes of Health (NIH), Bethesda, Maryland, with major support from the Centers for Disease Control and Prevention (CDC), Atlanta, the Commission of the European Communities (CEC), Brussels, and the World Health Organization (WHO), Geneva. A total of 180 persons involved in filovirus research and control from 30 countries participated, including 23 representatives from African countries where Ebola and Marburg virus infections have been detected. Seven themes were addressed: (1) emerging infectious diseases priorities, (2) recent Ebola virus outbreaks, with emphasis on Zaire and Gabon, (3) virology and molecular biology, (4) pathology and pathogenesis, (5) therapy and prevention, (6) natural history, including seroarchaeology, and (7) strengthening the filovirus research network. The colloquium commemorated the 20th anniversary of the first isolation, characterization, investigation, and control of Ebola virus, detected in Zaire and the Sudan in 1976.
KW  - human diseases
KW  - research
KW  - viral diseases
KW  - Ebolavirus
KW  - Filovirus
KW  - man
KW  - Filoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA Viruses
KW  - ssRNA Viruses
KW  - RNA Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Filovirus
KW  - Ebola virus
KW  - studies
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010637&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial.
AU  - Straus, S. E.
AU  - Wald, A.
AU  - Kost, R. G.
AU  - McKenzie, R.
AU  - Langenberg, A. G. M.
AU  - Hohman, P.
AU  - Lekstrom, J.
AU  - Cox, E.
AU  - Nakamura, M.
AU  - Sekulovich, R.
AU  - Izu, A.
AU  - Dekker, C.
AU  - Corey, L.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1997///
VL  - 176
IS  - 5
SP  - 1129
EP  - 1134
SN  - 0022-1899
AD  - Straus, S. E.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982001792.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Public Health
N2  - To determine the safety, immunogenicity, and efficacy of a recombinant herpes simplex virus type 2 glycoprotein D and B vaccine in the treatment of recurrent genital herpes, a randomized, placebo-controlled trial was held at two referral centres in Maryland and Washington, USA. Healthy patients with 4-14 recurrences per year received injections of both glycoproteins in MF59 adjuvant or of MF59 alone at 0, 2, 12, and 14 months. For 18 study months, the rate and number of recurrences, the duration and severity of the first confirmed recurrence, vaccine immunogenicity, and rates of local and systemic reactions were determined. The monthly rate of recurrences was not significantly improved, but the duration and severity of the first study outbreak was reduced significantly by vaccination. Glycoprotein-specific and neutralizing antibodies were boosted by vaccination for the duration of the study. In conclusion, this vaccine is safe and immunogenic and ameliorated an observed first postvaccination genital recurrence, but it does not reduce recurrence frequency.
KW  - antibodies
KW  - glycoproteins
KW  - herpes
KW  - herpes simplex
KW  - herpes simplex viruses
KW  - human diseases
KW  - human herpesviruses
KW  - immunization
KW  - immunotherapy
KW  - recombinant vaccines
KW  - relapse
KW  - vaccination
KW  - vaccines
KW  - Maryland
KW  - USA
KW  - Washington
KW  - Human herpesvirus 2
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - herpes simplex virus
KW  - herpes simplex virus 2
KW  - Human herpesvirus
KW  - immune sensitization
KW  - recurrence of disease
KW  - relapses
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001792&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The bacterial nucleoid visualized by fluorescence microscopy of cells lysed within agarose: comparison of Escherichia coli and spirochetes of the genus Borrelia.
AU  - Hinnebusch, B. J.
AU  - Bendich, A. J.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1997///
VL  - 179
IS  - 7
SP  - 2228
EP  - 2237
SN  - 0021-9193
AD  - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19970502512.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 9012-36-6, 9007-49-2.  Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2  - The nucleoids of E. coli and the spirochaetes B. burgdorferi and B. hermsii were examined by epifluorescence microscopy of bacterial cells embedded in agarose and lysed in situ with detergent and protease. The typical E. coli nucleoid was a rosette in which 20-50 long loops of DNA emanated from a dense node of DNA. The percentages of cells in a population having nucleoids with 0, 1, 2 and 3 nodes varied with growth rate and growth phase. The borrelia nucleoid, in contrast, was a loose network of DNA strands devoid of nodes. This nucleoid structure difference correlates with the unusual genome of Borrelia species, which consists primarily of linear replicons, including a 950-kb linear chromosome and linear plasmids. This method provides a simple, direct means to analyse the structure of the bacterial nucleoid.
KW  - agarose
KW  - cells
KW  - DNA
KW  - fluorescence microscopy
KW  - techniques
KW  - Borrelia
KW  - Borrelia burgdorferi
KW  - Borrelia hermsii
KW  - Escherichia coli
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Borrelia
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - E. coli
KW  - nucleoids
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970502512&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids.
AU  - Stevenson, B.
AU  - Casjens, S.
AU  - Vugt, R. van
AU  - Porcella, S. F.
AU  - Tilly, K.
AU  - Bono, J. L.
AU  - Rosa, P.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1997///
VL  - 179
IS  - 13
SP  - 4285
EP  - 4291
SN  - 0021-9193
AD  - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980500338.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - The authors mapped the genes encoding the antigenic lipoproteins OspE and OspF to an ~18-kb circular plasmid in B. burgdorferi N40. Sequencing and restriction mapping revealed that this plasmid, cp18, is homologous to an 18-kb region of the cp32 circular plasmids found in the Lyme disease spirochaetes. The data showed that cp18 may have arisen from an ancestral cp32 plasmid by deletion of a 14-kb region of DNA, indicating that a significant portion of the cp32 plasmid is not essential in cis for plasmid maintenance. These findings suggest that a relatively small recombinant plasmid capable of being stably maintained in B. burgdorferi could be constructed from a cp32 plasmid. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are U83898-U83899, and additional sequences are added to U42599 and U60963.
KW  - antigens
KW  - characterization
KW  - DNA
KW  - genes
KW  - lipoproteins
KW  - molecular genetics
KW  - nucleotide sequences
KW  - plasmids
KW  - surface proteins
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - immunogens
KW  - membrane proteins
KW  - outer surface proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500338&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii.
AU  - Scharton-Kersten, T. M.
AU  - Yap, G.
AU  - Magram, J.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1997///
VL  - 185
IS  - 7
SP  - 1261
EP  - 1273
SN  - 0022-1007
AD  - Scharton-Kersten, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980800508.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - To formally test in vivo the hypothesis that the induction by interferon-γ (IFN-γ) of reactive nitrogen intermediates is a major mechanism of host resistance to intracellular pathogens, the course of Toxoplasma gondii infection was assessed in nitric oxide synthase (iNOS)-/- mice. As expected, macrophages from these animals displayed defective microbicidal activity against the parasite in vitro. Nevertheless, in contrast to IFN-γ-/- or interleukin-12 (IL-12) p40-/- animals, iNOS-deficient mice survived acute infection and controlled parasite growth at the site of inoculation. This early resistance was ablated by neutralization of IFN-γ or IL-12 in vivo and markedly diminished by depletion of neutrophils, demonstrating the existence of previously unappreciated NO-independent mechanisms operating against the parasite during early infection. By 3-4 weeks pi, however, iNOS knockout mice did succumb to T. gondii. At that stage parasite expansion and pathology were evident in the central nervous system but not the periphery, suggesting that the protective role of nitric oxide against this intracellular infection is tissue-specific rather than systemic.
KW  - acute infections
KW  - animal diseases
KW  - chronic infections
KW  - experimental infections
KW  - human diseases
KW  - immune response
KW  - immunological factors
KW  - interferon
KW  - interleukin 12
KW  - laboratory animals
KW  - laboratory mammals
KW  - parasites
KW  - toxoplasmosis
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - nitric oxide synthase
KW  - severe infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800508&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins.
AU  - Palmer, L. D.
AU  - Weng NanPing
AU  - Levine, B. L.
AU  - June, C. H.
AU  - Lane, H. C.
AU  - Hodes, R. J.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1997///
VL  - 185
IS  - 7
SP  - 1381
EP  - 1386
SN  - 0022-1007
AD  - Palmer, L. D.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004651.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
N2  - To address the possible role of replicative senescence in HIV infection, telomere length, telomerase activity and in vitro replicative capacity were assessed in peripheral blood T cells from HIV+ and HIV- donors. Genetic and age-specific effects on these parameters were controlled by studying HIV-discordant pairs of monozygotic twins. Telomere terminal restriction fragment (TRF) lengths from CD4+ T cells of HIV+ donors were significantly greater than those from HIV- twins. In contrast, telomere lengths in CD8+ T cells from HIV+ donors were shorter than in HIV- donors. The in vitro replicative capacity of CD4+ cells from HIV+ donors was equivalent to that of HIV- donors in response to stimulation through T-cell receptor CD3 and CD28. Little or no telomerase activity was detected in freshly isolated CD4+ or CD8+ lymphocytes from HIV+ or HIV- donors, but was induced by in vitro stimulation of both HIV+ and HIV- donor cells. It is suggested that HIV infection is associated with alterations in the population dynamics of both CD4+ and CD8+ T cells, but the results fail to provide evidence for clonal exhaustion or replicative senescence as a mechanism underlying the decline in CD4+ T cells of HIV-infected donors.
KW  - age differences
KW  - analysis
KW  - donors
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - length
KW  - lymphocytes
KW  - microbiology
KW  - monozygotic twins
KW  - pathogenesis
KW  - populations
KW  - receptors
KW  - responses
KW  - stimulation
KW  - t lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004651&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.
AU  - Liao, F.
AU  - Alkhatib, G.
AU  - Peden, K. W. C.
AU  - Sharma, G.
AU  - Berger, E. A.
AU  - Farber, J. M.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1997///
VL  - 185
IS  - 10
SP  - 2015
EP  - 2023
SN  - 0022-1007
AD  - Liao, F.: National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972006121.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - As part of studies on the roles of chemokines in lymphocyte biology, experiments were designed to identify novel chemokine receptors in human T cells. This report describes the molecular cloning of a cDNA for STRL33, a gene encoding a GPCR related to known chemokine receptors that is expressed in lymphoid tissues and activated T cells, and is induced in activated PBL. It is demonstrated that STRL33, in marked contrast with CXCR4 and CCR5, can function with CD4 as a cofactor for cell fusion mediated by Envs of both M-tropic and TCL-tropic strains of HIV-1 and that transfection with STRL33 significantly enhances the ability of Jurkat cells to support productive infection with HIV-1. These data suggest that STRL33 may play a role in the establishment and/or the course of HIV-1 infection.
KW  - CD4 antigens
KW  - chemokines
KW  - cofactors
KW  - complementary DNA
KW  - experiments
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - infection
KW  - lymphocytes
KW  - receptors
KW  - strains
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - CD4
KW  - cDNA
KW  - cloning
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006121&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major.
AU  - Gurunathan, S.
AU  - Sacks, D. L.
AU  - Brown, D. R.
AU  - Reiner, S. L.
AU  - Charest, H.
AU  - Glaichenhaus, N.
AU  - Seder, R. A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1997///
VL  - 186
IS  - 7
SP  - 1137
EP  - 1147
SN  - 0022-1007
AD  - Gurunathan, S.: Lymphokine Regulation Unit, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980803818.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 9007-49-2, 308067-58-5, 9008-11-1.  Subject Subsets: Protozoology
N2  - To determine whether DNA immunization could elicit protective immunity to Leishmania major in susceptible BALB/c mice, cDNA for the cloned Leishmania antigen LACK was inserted into a eukaryotic expression vector downstream to the cytomegalovirus promoter. Susceptible BALB/c mice were then vaccinated subcutaneously with LACK DNA and challenged with L. major promastigotes. The protective efficacy (measured by footpad swelling or the number of parasites per mg of tissue) of LACK DNA vaccination was compared with that of recombinant LACK protein with or without recombinant interleukin (rIL)-12 protein. It was found to be similar to that achieved by LACK protein and rIL-12, but much superior to that achieved by LACK protein without rIL-12. The immunity conferred by LACK DNA was durable insofar as mice challenged 5 weeks after vaccination were still protected, and the infection was controlled for at least 20 weeks after challenge. In addition, the ability of mice to control infection at sites distant to the site of vaccination suggests that systemic protection was achieved. Immunity was dose-dependent. The control of disease progression and parasitic burden in mice vaccinated with LACK DNA was associated with enhancement of antigen-specific interferon-γ (IFN-γ) and IgG production. Both the enhancement of IFN-γ production and the protective immune response induced by LACK DNA vaccination were IL-12 dependent, as shown by treating mice with a neutralizing antibody against IL-12. Unexpectedly, depletion of CD8+ T cells at the time of vaccination or infection also abolished the protective response induced by LACK DNA vaccination, suggesting a role for these cells in DNA-vaccine-induced protection against L. major. It is concluded that DNA immunization may offer an attractive alternative vaccination strategy against intracellular pathogens, as compared with conventional vaccination with antigens combined with adjuvants.
KW  - animal diseases
KW  - antigens
KW  - CD8+ lymphocytes
KW  - DNA
KW  - DNA vaccines
KW  - experimental infections
KW  - human diseases
KW  - IgG
KW  - immunity
KW  - immunization
KW  - interferon
KW  - interleukin 12
KW  - laboratory animals
KW  - laboratory mammals
KW  - leishmaniasis
KW  - parasites
KW  - promastigotes
KW  - proteins
KW  - recombinant proteins
KW  - vaccination
KW  - vaccine development
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - antigenicity
KW  - CD8+ cells
KW  - deoxyribonucleic acid
KW  - immune sensitization
KW  - immunogens
KW  - leishmaniosis
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.
AU  - Reis e Sousa, C.
AU  - Hieny, S.
AU  - Scharton-Kersten, T.
AU  - Jankovic, D.
AU  - Charest, H.
AU  - Germain, R. N.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1997///
VL  - 186
IS  - 11
SP  - 1819
EP  - 1829
SN  - 0022-1007
AD  - Reis e Sousa, C.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-1872, USA.
N1  - Accession Number: 19980803938.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Protozoology
N2  - The early induction of interleukin (IL)-12 is a critical event in determining the development of both innate resistance and adaptive immunity to many intracellular pathogens. Previous in vitro studies have suggested that the macrophage (MΦ) is a major source of the initial IL-12 produced upon microbial stimulation and that this response promotes the differentiation of protective T helper cell 1 (Th1) CD4+ lymphocytes from precursors that are primed on antigen-bearing dendritic cells (DC). Immunolocalization experiments and flow cytometric analysis were used to show that, contrary to expectation, DC and not MΦ are the initial cells to synthesize IL-12 in the spleens of mice exposed in vivo to an extract of Toxoplasma gondii or to lipopolysaccharide, 2 well characterized microbial stimulants of this cytokine. This production of IL-12 occurs very rapidly and is independent of interferon-γ priming or of signals from T cells, such as CD40 ligand. IL-12 production by splenic DC is accompanied by an increase in number of DCs, as well as a redistribution to the T cell areas and the acquisition of markers characteristic of interdigitating dendritic cells. The capacity of splenic DC but not MΦ to synthesize de novo high levels of IL-12 within hours of exposure to microbial products in vivo, as well as the ability of the same stimuli to induce migration of DC to the T cell areas, argues that DC function simultaneously as both antigen-presenting cells and IL-12 producing accessory cells in the initiation of cell-mediated immunity to intracellular pathogens. This model avoids the need to invoke a 3-cell interaction for Th1 differentiation and points to the DC as both a sentinel for innate recognition and the dictator of class selection in the subsequent adaptive response.
KW  - dendritic cells
KW  - experimental infections
KW  - immune response
KW  - interleukin 12
KW  - laboratory animals
KW  - macrophages
KW  - parasites
KW  - resistance
KW  - T lymphocytes
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Two tandemly arrayed genes encode the (histidine) secretory acid phosphatases of Leishmania donovani.
AU  - Shakarian, A. M.
AU  - Ellis, S. L.
AU  - Mallinson, D. J.
AU  - Olafson, R. W.
AU  - Dwyer, D. M.
JO  - Gene
JF  - Gene
Y1  - 1997///
VL  - 196
IS  - 1/2
SP  - 127
EP  - 137
SN  - 0378-1119
AD  - Shakarian, A. M.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990800807.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9001-77-8, 71-00-1.  Subject Subsets: Protozoology
N2  - Secretory acid phosphatase (SAcP) was purified from Leishmania donovani culture supernatants and the amino-acid sequence was obtained from both the N-terminus and a tryptic peptide fragment derived from the isolated protein. A polymerase chain reaction (PCR)-based strategy, using degenerate oligo primers designed from the amino-acid sequence data, identified 2 single-copy, tandemly arrayed open reading frames capable of encoding the L. donovani SAcP (SAcP-1, 2052 bp and SAcP-2, 2124 bp). Both SAcP-1 and -2 were shown to be actively transcribed by L. donovani promastigotes by reverse transcription and PCR amplification. The deduced amino-acid sequences of SAcP-1 and SAcP-2 showed high conservation to each other in 4 regions: a 23-amino-acid signal peptide; a catalytic domain containing several potential N-linked glycosylation sites; a Ser/Thr-rich repeat region containing multiple potential phosphorylation sites; and a common C-terminus. Within the catalytic domain, the L. donovani SAcPs possessed 2 conserved consensus sequences characteristic of histidine acid phosphatases (AcPs). Antisera to native L. donovani SAcP immunoprecipitated in vitro transcription/translation products of both SAcP-1 and SAcP-2. The data indicate that the acid phosphatase activity secreted by L. donovani promastigotes is composed of 2 (histidine) AcP isoforms that are encoded by SAcP-1 and SAcP-2, respectively.
KW  - acid phosphatase
KW  - amino acid sequences
KW  - enzymes
KW  - excretory secretory products
KW  - genes
KW  - histidine
KW  - molecular genetics
KW  - open reading frames
KW  - parasites
KW  - polymerase chain reaction
KW  - promastigotes
KW  - Leishmania donovani
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - acid phosphomonoesterase
KW  - biochemical genetics
KW  - ORFs
KW  - PCR
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytotoxic T lymphocyte (CTL) adherence assay (CAA): a non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes.
AU  - Leggatt, G. R.
AU  - Alexander-Miller, M. A.
AU  - Kumar, A. M.
AU  - Hoffman, S. L.
AU  - Berzofsky, J. A.
JO  - Journal of Immunological Methods
JF  - Journal of Immunological Methods
Y1  - 1997///
VL  - 201
IS  - 1
SP  - 1
EP  - 10
SN  - 0022-1759
AD  - Leggatt, G. R.: Metabolism Branch, National Cancer Institute, Building 10, Room 6B-12, National Institutes of Health, Bethesda, MD 20892-1578, USA.
N1  - Accession Number: 19970802387.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Protozoology
N2  - A simple visual assay for identifying peptides specifically recognized by cytotoxic T lymphocytes (CTL) is described, based on the discovery that CTL develop increased adhesive properties upon T cell receptor (TCR) triggering. Several murine CTL lines were shown to pellet to the bottom of a 96-well plate in the absence of peptide. In contrast, these same CTL lines incubated with their cognate peptide, allowing them to present peptide to each other, adhered to the sides of the well and were readily distinguished by macroscopic visual examination of the plate after 4-5 h or overnight incubation. This CTL adherence assay (CAA) demonstrated peptide specificity and MHC restriction, and was titratable with peptide concentration. With this technique, a minimal-sized Plasmodium falciparum CTL epitope was correctly identified from a panel of overlapping nonamers, although the adherence pattern of 2 mono-substituted variant peptides was less predictive of lytic activity. Substitutions in an HIV-1 envelope CTL epitope that reduced lytic activity were correctly predicted. On preincubation, inhibitors of RNA and protein synthesis abrogated the adherence, indicating a need for live cells. Wortmannin, a PI-3 kinase inhibitor, inhibited the peptide specific adherence, consistent with a role for TCR or integrin signal transduction in CAA. Other cytoskeletal and metabolic inhibitors had no effect. Adherence of the T cells appeared to involve low affinity nonspecific interactions. CAA may represent a rapid simple method for screening large numbers of peptides to find cytolytic epitopes for a given CTL line and may identify additional epitopes causing T cell activation and adherence, but not cytolytic activity.
KW  - assays
KW  - cell lines
KW  - cytoadherence
KW  - epitopes
KW  - immune response
KW  - in vitro
KW  - inhibitors
KW  - laboratory animals
KW  - major histocompatibility complex
KW  - methodology
KW  - parasites
KW  - peptides
KW  - T lymphocytes
KW  - techniques
KW  - mice
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - antigenic determinants
KW  - cell adhesion
KW  - histocompatibility complex
KW  - immunity reactions
KW  - immunological reactions
KW  - methods
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802387&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of HIV-1 transcription and virus replication using soluble Tat peptide analogs.
AU  - Kashanchi, F.
AU  - Sadaie, M. R.
AU  - Brady, J. N.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1997///
VL  - 227
IS  - 2
SP  - 431
EP  - 438
SN  - 0042-6822
AD  - Kashanchi, F.: Virus Tumor Biology Section, Laboratory of Molecular Virology, National Cancer Institute, NIH Bethesda, MD 20892, USA.
N1  - Accession Number: 19972002468.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref.
N2  - This is an interesting initial study which demonstrates that peptide analogues of Tat can directly inhibit HIV-1 induction from latently-infected cells after stimulation. This may be an important new approach for anti-HIV-1 gene therapy. Further studies will be necessary in primary human cell types to determine the potency of this effect as an intracellular immunization technology.
KW  - analogues
KW  - antigens
KW  - genes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - microbiology
KW  - peptides
KW  - promoters
KW  - regulatory genes
KW  - replication
KW  - tat gene
KW  - transactivation
KW  - transcription
KW  - viral replication
KW  - Deltaretrovirus
KW  - Human immunodeficiency virus 1
KW  - human T-cell lymphotropic virus type I
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - analogs
KW  - antigenicity
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - promoter region
KW  - promoter sequences
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002468&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Posttranscriptional regulation by Rev protein of human immunodeficiency virus type 1 results in nonrandom nuclear localization of gag mRNA.
AU  - Romanov, V. I.
AU  - Zolotukhin, A. S.
AU  - Aleksandroff, N. N.
AU  - Silva, P. P. da
AU  - Felber, B. K.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1997///
VL  - 228
IS  - 2
SP  - 360
EP  - 370
SN  - 0042-6822
AD  - Romanov, V. I.: Human Retrovirus Pathogenesis Group, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972003121.  Publication Type: Journal Article.  Language: English. 
N2  - The expression of HIV-1 mRNAs containing the Rev-responsive element is regulated at the posttranscriptional level by the viral Rev protein. Rev increases the nucleocytoplasmic export of these mRNAs, leading to high expression. Using in situ hybridization and electron microscopy, the authors investigated the localization of a subgenomic gag mRNA in the absence and presence of Rev. In addition to the previously shown cytoplasmic accumulation of the Rev-dependent RNA, it was observed that in the presence of Rev the nuclear gag mRNA accumulates non randomly and forms specific localization patterns at the nuclear membrane and in the nucleoplasm. Cellular mRNAs for β-actin and glyceraldehyde-3-phosphate dehydrogenase were not found to form such patterns. These data suggest that Rev leads the gag mRNA to specific subnuclear locations, which further supports the transport function of Rev.
KW  - cells
KW  - Gag protein
KW  - HIV-1 infections
KW  - human diseases
KW  - localization
KW  - messenger rna
KW  - microbiology
KW  - regulatory genes
KW  - rev gene
KW  - Rev protein
KW  - transcription
KW  - transport
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - DNA transcription
KW  - human immunodeficiency virus type 1
KW  - mRNA
KW  - transportation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003121&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations.
AU  - Bess, J. W., Jr.
AU  - Gorelick, R. J.
AU  - Bosche, W. J.
AU  - Henderson, L. E.
AU  - Arthur, L. O.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1997///
VL  - 230
IS  - 1
SP  - 134
EP  - 144
SN  - 0042-6822
AD  - Bess, J. W., Jr.: AIDS Vaccine Program, SAIC, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972004712.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 63231-63-0, 57-50-1. 
N2  - Microvesicles band in sucrose gradients in a range of densities that includes the same density as retroviruses. To characterize these microvesicles, HIV-1 infected and uninfected human T-cell lines were propagated and viruses and microvesicles were purified from clarified cell culture supernatants by sucrose density gradient centrifugation or centrifugation through 20% sucrose pads. Microvesicles were found to contain various proteins, including HLA DR and β2-microglobulin (β2-M), and a substantial amount of RNA and DNA. The concentrations of HIV-1 p24CA, HLA DR and β2-M were determined by radioimmunoassay. The ratios of HIV-1 p24CA to HLA DR and β2-M varied with respect to the HIV-1 isolate, host cell, and other factors. Electron microscopic analysis of microvesicles revealed that they consisted of particles of various sizes and morphologies. Although HIV-1 particles are known to contain some cellular proteins, microvesicles from HIV-1 infected H9 cells appeared to contain little or no HIV-1 gp120SU.
KW  - cell lines
KW  - concentration
KW  - contamination
KW  - hiv infections
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - laboratory methods
KW  - methodology
KW  - proteins
KW  - RNA
KW  - sucrose
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - laboratory techniques
KW  - methods
KW  - other methods
KW  - ribonucleic acid
KW  - saccharose
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses.
AU  - Giri, A.
AU  - Slattery, J. P.
AU  - Heneine, W.
AU  - Gessain, A.
AU  - Rivadeneira, E.
AU  - Desrosiers, R. C.
AU  - Rosen, L.
AU  - Anthony, R.
AU  - Pamungkas, J.
AU  - Iskandriati, D.
AU  - Richards, A. L.
AU  - Herve, V.
AU  - McClure, H.
AU  - O'Brien, S. J.
AU  - Franchini, G.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1997///
VL  - 231
IS  - 1
SP  - 96
EP  - 104
SN  - 0042-6822
AD  - Giri, A.: Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972005260.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
N2  - A genetically diverse, monophyletic lineage consisting of 8 new viral strains from several species of Asian macaques was identified. The second lineage consisted of a monophyletic assemblage of HTLV-II/STLV-II strains from Africa and the New World, including an isolate from a pygmy chimp (Pan paniscus) as an early divergence within the lineage. High levels of genetic variation among strains from Asian STLV-I macaque suggest the virus arose in Asia. Evidence of the origin of the type II virus is less clear, but diversity among HTLV-II variants from a single isolated population of Mbati villagers is suggestive but not proof of an African origin.
KW  - diversity
KW  - genetic variation
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - microbiology
KW  - populations
KW  - strains
KW  - T lymphocytes
KW  - Africa
KW  - Asia
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type II
KW  - Macaca
KW  - monkeys
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - HTLV-BLV group
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - other Retroviridae
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro.
AU  - Derse, D.
AU  - Mikovits, J.
AU  - Ruscetti, F.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1997///
VL  - 237
IS  - 1
SP  - 123
EP  - 128
SN  - 0042-6822
AD  - Derse, D.: Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute, Frederick MD 21702-1201, USA.
N1  - Accession Number: 19972010690.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
N2  - To identify possible functions for ORFs X-1 and X-II, an infectious molecular clone of HTLV-I and a mutant provirus lacking these ORFs were compared with respect to virus replication, gene expression, and ability to immortalize primary T cells. When transiently transfected into 293 cells, both intact and deleted proviruses directed the synthesis of virus mRNAs and proteins that were quantitatively and qualitatively identical. These viruses were also indistinguishable in their abilities to infect and replicate in DBS-FRhL cells, which are permissive for HTLV-I propagation. Immortalized T-cell lines were established after cell-free or coculture methods for infection of activated, human peripheral blood or cord blood lymphocytes with each of the cloned viruses. The growth kinetics, cytokine dependence, and cell surface markers of the infected T-cell cultures were similar for each provirus clone. Thus, ORFs X-1 and X-II are not essential for virus infectivity, replication, gene expression, or T-cell immortalization in vitro.
KW  - cell lines
KW  - clones
KW  - culture media
KW  - culture techniques
KW  - cytokines
KW  - HTLV-I infections
KW  - human diseases
KW  - infection
KW  - lymphocytes
KW  - open reading frames
KW  - proteins
KW  - proviruses
KW  - replication
KW  - surface proteins
KW  - synthesis
KW  - T lymphocytes
KW  - viral replication
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - HTLV-BLV group
KW  - membrane proteins
KW  - ORFs
KW  - T cells
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010690&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family.
AU  - Ohno, H.
AU  - Aguilar, R. C.
AU  - Fournier, M. C.
AU  - Hennecke, S.
AU  - Cosson, P.
AU  - Bonifacino, J. S.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1997///
VL  - 238
IS  - 2
SP  - 305
EP  - 315
SN  - 0042-6822
AD  - Ohno, H.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982000298.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Registry Number: 11096-37-0. 
N2  - The resemblance of the Env endocytic signals to other signals found in host cell proteins suggests that they may share the same endocytic machinery. This study demonstrates that this is indeed the case. Over-expression of proteins having the tyrosine-based signals of the Env complex saturates the intracellular sorting machinery and, as a consequence, increases the surface expression of the transferrin receptor (TfR), a protein that is normally internalized by virtue of a tyrosine-based signal. Furthermore, it is demonstrated that the tyrosine-based signals of the HIV-1 Env complex bind to the µ2 chain of clathrin-associated adaptor complex AP-2, a protein that was previously implicated in the endocytosis of other cellular proteins. Finally, it is shown that the same signals interact with two other members of the adaptor medium chain family, µ1 and µ3A, albeit with lower avidity.
KW  - cells
KW  - envelope glycoproteins
KW  - glycoproteins
KW  - HIV-1 infections
KW  - hosts
KW  - human diseases
KW  - pathogenesis
KW  - plasma membranes
KW  - proteins
KW  - receptors
KW  - transferrin
KW  - uptake
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cell membrane
KW  - human immunodeficiency virus type 1
KW  - internalization
KW  - plasmalemma
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000298&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - Regulation and trafficking of three distinct 18 S ribosomal RNAs during development of the malaria parasite.
AU  - Li Jun
AU  - Gutell, R. R.
AU  - Damberger, S. H.
AU  - Wirtz, R. A.
AU  - Kissinger, J. C.
AU  - Rogers, M. J.
AU  - Sattabongkot, J.
AU  - McCutchan, T. F.
JO  - Journal of Molecular Biology
JF  - Journal of Molecular Biology
Y1  - 1997///
VL  - 269
IS  - 2
SP  - 203
EP  - 213
SN  - 0022-2836
AD  - Li Jun: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000804060.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Protozoology
N2  - Developmental progression in Plasmodium vivax is correlated with changes in regions of ribosomal RNA sequence. The A-type ribosome is predominantly found in infected erythrocytes and in the vector blood meal; transcripts from the A gene are replaced by transcripts from the O gene shortly after fertilization and increase in number as the parasite develops in the vector midgut; transcripts from the S gene begin as the parasite oocyst matures and are included in sporozoites that migrate to the salivary gland.
KW  - biological development
KW  - blood-meals
KW  - development
KW  - developmental stages
KW  - disease vectors
KW  - erythrocytes
KW  - gene expression
KW  - genes
KW  - life cycle
KW  - malaria
KW  - midgut
KW  - molecular genetics
KW  - nucleotide sequences
KW  - oocysts
KW  - parasites
KW  - ribosomal RNA
KW  - ribosomes
KW  - salivary glands
KW  - sporozoites
KW  - transcription
KW  - Plasmodium vivax
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - blood red cells
KW  - DNA sequences
KW  - DNA transcription
KW  - growth phase
KW  - red blood cells
KW  - rRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804060&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of Plasmodium falciparum protein synthesis: targeting the plastid-like organelle with thiostrepton.
AU  - McConkey, G. A.
AU  - Rogers, M. J.
AU  - McCutchan, T. F.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 4
SP  - 2046
EP  - 2049
SN  - 0021-9258
AD  - McConkey, G. A.: Growth and Development Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19970801942.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 9007-49-2, 13292-46-1.  Subject Subsets: Protozoology
N2  - Plasmodium falciparum has 2 extrachromosomal DNAs associated with organelles whose function is unclear. Both genomes encode ribosomal RNAs (rRNAs) that are distinct from the nuclear-encoded rRNAs. Secondary structure analysis of all the P. falciparum rRNAs indicated that only the large subunit (LSU) rRNA encoded by the plastid-like genome is the target for thiostrepton (a thiazole-containing peptide antibiotic). Thiostrepton inhibited growth of the parasite in the micromolar range, which is 10-fold lower than concentrations with observable effects on total protein synthesis. The selective effects of thiostrepton on the plastid function were further examined by comparing differential effects of the drug on cytoplasmic and organellar encoded transcripts. Treatment with either thiostrepton or rifampin [rifampicin] (an inhibitor of organellar and eubacterial RNA polymerase) showed disappearance of organellar-encoded RNA transcripts within 6 h of treatment while transcripts of a nuclear-encoded mRNA remained constant for at least 8 h. The results demonstrate a selective effect on organelle function that is suggestive of interference in the protein synthesis apparatus of the plastid. The sensitivity of P. falciparum to thiostrepton confirms that the plastid-like genome is essential for the erythrocytic cycle and presents a novel therapeutic site.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - DNA
KW  - genomes
KW  - growth inhibitors
KW  - in vitro
KW  - inhibitors
KW  - mode of action
KW  - organelles
KW  - parasites
KW  - plastids
KW  - protein synthesis
KW  - ribosomal RNA
KW  - rifampicin
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - protein biosynthesis
KW  - rifampin
KW  - rifamycin amp
KW  - rRNA
KW  - thiostrepton
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801942&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
AU  - Kannan, S.
AU  - Santis, M. de
AU  - Lohmeyer, M.
AU  - Riese, D. J., II
AU  - Smith, G. H.
AU  - Hynes, N.
AU  - Seno, M.
AU  - Brandt, R.
AU  - Bianco, C.
AU  - Persico, G.
AU  - Kenney, N.
AU  - Normanno, N.
AU  - Martínez Lacaci, I.
AU  - Ciardiello, F.
AU  - Stern, D. F.
AU  - Gullick, W. J.
AU  - Salomon, D. S.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 6
SP  - 3330
EP  - 3335
SN  - 0021-9258
AD  - Kannan, S.: Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, NIC, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19970401616.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9026-43-1, 60-18-4.  Subject Subsets: Dairy Science
N2  - Cripto-1 (CR-1), a recently discovered protein of the epidermal growth factor (EGF) family, interacted with a high-affinity, saturable binding site(s) on HC-11 mouse mammary epithelial cells and on several different human breast cancer cell lines. This receptor exhibits specificity for CR-1, since other EGF-related peptides including EGF, transforming growth factor-α, heparin-binding EGF-like growth factor, amphiregulin, epiregulin, betacellulin or heregulin-β1 that bind to either the EGF receptor or to other type 1 receptor tyrosine kinases such as erb B-3 or erb B-4 fail to compete for binding. Conversely, CR-1 did not directly bind to or activate the tyrosine kinases associated with the EGFR, erb B-2, erb B-3 or erb B-4 either alone or in various pairwise combinations which have been ectopically expressed in Ba/F3 mouse pro-B lymphocyte cells. However, exogenous CR-1 could induce an increase in the tyrosine phosphorylation of 185- and 120-kDa proteins and a rapid (within 3-5 min) increase in the tyrosine phosphorylation of the SH2-containing adaptor proteins p66, p52 and p46 Shc in mouse mammary HC-11 epithelial cells and in human MDA-MB-453 and SKBr-3 breast cancer cells. CR-1 also promoted an increase in the association of the adaptor Grb2-guanine nucleotide exchange factor-mouse son of sevenless (mSOS) signalling complex with tyrosine-phosphorylated Shc in HC-11 cells. Finally, CR-1 was able to increase p42erk-2 mitogen-activated protein kinase (MAPK) activity in HC-11 cells within 5-10 min of treatment. It is concluded that CR-1 can function through a receptor which activates intracellular components in the ras/raf/MEK/MAPK pathway.
KW  - cell lines
KW  - cells
KW  - epidermal growth factor
KW  - epithelium
KW  - growth factors
KW  - kinases
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - neoplasms
KW  - nucleotides
KW  - peptides
KW  - phosphorylation
KW  - protein kinase
KW  - receptors
KW  - tyrosine
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - amphiregulin
KW  - betacellulin
KW  - cancers
KW  - epiregulin
KW  - heregulin
KW  - mammary tumour
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970401616&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mammalian GADD34, an apoptosis- and DNA damage-inducible gene.
AU  - Hollander, M. C.
AU  - Zhan QiMin
AU  - Bae, I.
AU  - Fornace, A. J., Jr.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 21
SP  - 13731
EP  - 13737
SN  - 0021-9258
AD  - Hollander, M. C.: Laboratory of Molecular Pharmacology, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19970105595.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - Induction of the human DNA damage- and growth arrest-inducible gene, GADD34, by ionizing radiation was only seen in certain cell lines and correlated with apoptosis following ionizing radiation. In addition, the kinetics and dose response of GADD34 to ionizing radiation closely paralleled that of the apoptosis inhibitor, BAX. However, unlike BAX, the GADD34 response was independent of cellular p53 status. The C-terminus of GADD34 has homology with the C-termini of 2 viral proteins, one of which is known to prevent apoptosis of virus infected cells. The association of GADD34 expression with certain types of apoptosis and its homology with a known apoptosis regulator suggests that GADD34 may play a role in apoptosis as well.
KW  - apoptosis
KW  - dna repair
KW  - genes
KW  - kinetics
KW  - neoplasms
KW  - mammals
KW  - man
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - cancers
KW  - homology
KW  - tumour suppressors
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970105595&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid.
AU  - Rumsey, S. C.
AU  - Kwon, O.
AU  - Xu GuoWei
AU  - Burant, C. f.
AU  - Simpson, I.
AU  - Levine, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 30
SP  - 18982
EP  - 18989
SN  - 0021-9258
AD  - Rumsey, S. C.: NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19981402542.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Registry Number: 50-81-7, 490-83-5, 50-99-7.  Subject Subsets: Human Nutrition; Animal Nutrition
N2  - Using the Xenopus laevis oocyte expression system, transport of dehydroascorbic acid (DHA) and ascorbic acid (AA) via glucose transporter isoforms GLUT1-5 and SGLT1 was studied. The apparent Km of DHA transport via GLUT1 and GLUT3 was 1.1±0.2 and 1.7±0.3 mM, respectively. HPLC analysis confirmed 100% reduction of DHA to AA within oocytes. GLUT4 transport of DHA was only 2- to 4-fold above control and transport kinetics could not be calculated. GLUT2, GLUT5, and SGLT1 did not transport DHA and none of the isoforms transported AA. Radiolabelled sugar transport confirmed transporter function and identity of all cDNA clones was confirmed by restriction fragment mapping. GLUT1 and GLUT3 cDNA were further verified by polymerase chain reaction. DHA transport activity in GLUT1 and GLUT3 was inhibited by 2-deoxyglucose, D-glucose, and 3-O-methylglucose among other hexoses while fructose and L-glucose showed no inhibition. Inhibition by the endofacial inhibitor, cytochalasin B, was non-competitive and inhibition by the exofacial inhibitor, 4,6-O-ethylidene-α-glucose, was competitive. Expressed mutant constructs of GLUT1 and GLUT3 did not transport DHA. DHA and 2-deoxyglucose uptake by Chinese hamster ovary cells overexpressing GLUT1 or GLUT3 was increased 2- to 8-fold over control cells. These studies suggest GLUT1 and GLUT3 isoforms are the specific glucose transporter isoforms which mediate DHA transport and subsequent accumulation of AA.
KW  - absorption
KW  - ascorbic acid
KW  - cell culture
KW  - cell cultures
KW  - cells
KW  - dehydroascorbic acid
KW  - glucose
KW  - transport
KW  - vitamins
KW  - dextrose
KW  - transportation
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Tissue and Cell Culture (LL700) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402542&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions.
AU  - Alkhatib, G.
AU  - Berger, E. A.
AU  - Murphy, P. M.
AU  - Pease, J. E.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 33
SP  - 20420
EP  - 20426
SN  - 0021-9258
AD  - Alkhatib, G.: Correspondence address [Murphy, P. M.]: Laboratory of Host Defenses, National Institutes of Health, Bldg 10, 11N113, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972008633.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref.
N2  - The chemokine receptors CXCR4, CCR2b, CCR3, and CCR5 are cell entry co-receptors for HIV-1. Using an HIV-l envelope (Env)-dependent cell-cell fusion model of entry, it was shown that CCR3 can interact with Envs from certain macrophage (M)-tropic strains (which also use CCR5), T cell line (TCL)-tropic laboratory-adapted strains (which also use CXCR4), and a dual-tropic primary isolate (which also uses CCR2b, CCR5, and CXCR4). Paradoxically, CCRl is the closest homologue to CCR3 (63% amino acid identity), but lacked HIV-1 co-receptor activity. These results confirm and extend previous reports. Replacing the N-terminal segment of CCR3 with that of CCRl abolished activity of the resulting chimera for M-tropic and TCL-tropic Envs, but not for the dual-tropic Env. Replacing extracellular loop 2 of CCR3 with that of CCRl abolished activity for TCL-tropic Envs, but not for M- and dual-tropic Envs. A chimera containing all four extracellular regions of CCR3 on a backbone of CCR1 lacked any activity. Env-CCR3 interactions were strongly inhibited by the major CCR3 ligand eotaxin, but weakly or not at all by other CCR3 ligands. With primary macrophages, eotaxin induced transient calcium flux and partially inhibited fusion with cells expressing M-tropic Envs. It is concluded that specificity determinants for different Envs are located in shared and distinct extracellular regions of CCR3, the transmembrane/cytoplasmic domains make major contributions to co-receptor function, and CCR3 may be used by certain HIV-1 strains as a cell fusion factor on macrophages.
KW  - cell invasion
KW  - cell lines
KW  - chemokines
KW  - chimaeras
KW  - immunology
KW  - macrophages
KW  - receptors
KW  - strains
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - ccr2b
KW  - ccr3
KW  - ccr5
KW  - chemokine receptors
KW  - chimeras
KW  - coreceptors
KW  - cxcr4
KW  - human immunodeficiency virus type 1
KW  - specificity
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008633&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The isolated RNase H domain of murine leukemia virus reverse transcriptase. Retention of activity with concomitant loss of specificity.
AU  - Zhan XinYi
AU  - Crouch, R. J.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 35
SP  - 22023
EP  - 22029
SN  - 0021-9258
AD  - Zhan XinYi: Correspondence address [Crouch, R. J.]: Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972008631.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9068-38-6. 
N2  - Retroviral RNases H are similar in sequence and structure to Escherichia coli RNase HI and yet have differences in substrate specificities, metal ion requirements, and specific activities. Separation of reverse transcriptase (RT) into polymerase and RNase H domains yields an active RNase H from murine leukaemia virus (MuLV) but an inactive HIV RNase H. The "handle region" present in E.coli RNase HI but absent in HIV RNase H contributes to the binding to its substrate and when inserted into HIV RNase H results in an active enzyme retaining some degree of specificity. Here, it is shown that MuLV protein containing the C-terminal 175 amino acids with its own handle region or that of E.coli RNase HI has the same specific activity as the RNase H of RT, but retains a preference for MN2+ as the cation required for activity, and has association rate (KA) 10% that of E.coli RNase HI. However, with model substrates, specificities for removal of the tRNAPro primer and polypurine tract stability are lost, indicating specificity of RNase H of MuLV requires the remainder of the RT. Differences in KA while significant, appear insufficient to account for the differences in specific activities of the bacterial and viral RNases H.
KW  - amino acids
KW  - human immunodeficiency viruses
KW  - leukaemia
KW  - microbiology
KW  - molecular biology
KW  - molecular genetics
KW  - reverse transcriptase
KW  - ribonucleases
KW  - structural genes
KW  - retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - biochemical genetics
KW  - blood cancer
KW  - human immunodeficiency virus
KW  - leucaemia
KW  - leukemia
KW  - other Retroviridae
KW  - RNASE
KW  - RNase H
KW  - specificity
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008631&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin.
AU  - Gong DaWei
AU  - He YuFang
AU  - Karas, M.
AU  - Reitman, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 39
SP  - 24129
EP  - 24132
SN  - 0021-9258
AD  - Gong DaWei: Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1770, USA.
N1  - Accession Number: 19981407540.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 1926-94-9, 2265-67-7, 2392-39-4, 312-93-6, 50-02-2, 55812-90-3, 7743-96-6, 16978-57-7, 1879-72-7, 169494-85-3.  Subject Subsets: Human Nutrition
N2  - Uncoupling protein (UCP)3 is expressed at high levels in muscle and rodent brown adipose tissue. Overexpression in yeast reduced the mitochondrial membrane potential, showing that UCP3 is a functional uncoupling protein. UCP3 RNA levels are regulated by hormonal and dietary manipulations. In contrast, levels of UCP2, a widely expressed UCP family member, showed little hormonal regulation. In particular, muscle UCP3 levels were decreased 3-fold in hypothyroid rats and increased 6-fold in hyperthyroid rats. Thus UCP3 is a strong candidate to explain the effects of thyroid hormone on thermogenesis. White adipose UCP3 levels were greatly increased by treatment with the β3-adrenergic agonist, CL214613, suggesting another pathway for increasing thermogenesis. UCP3 mRNA levels were also regulated by dexamethasone, leptin and starvation, albeit differently in muscle and brown adipose tissue. Starvation caused increased muscle and decreased BAT UCP3, suggesting that muscle assumes a larger role in thermoregulation during starvation. The UCP3 gene is located close to that encoding UCP2, in a chromosomal region implicated in previous linkage studies as contributing to obesity.
KW  - adipose tissue
KW  - brown fat
KW  - dexamethasone
KW  - gene expression
KW  - heat production
KW  - leptin
KW  - obesity
KW  - regulation
KW  - skeletal muscle
KW  - starvation
KW  - thyroid gland
KW  - thyroid hormones
KW  - tissues
KW  - mice
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorigenesis
KW  - fatness
KW  - thermogenesis
KW  - thyroid
KW  - uncoupling protein
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407540&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro.
AU  - Davis, D. A.
AU  - Newcomb, F. M.
AU  - Starke, D. W.
AU  - Ott, D. E.
AU  - Mieyal, J. J.
AU  - Yarchoan, R.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1997///
VL  - 272
IS  - 41
SP  - 25935
EP  - 25940
SN  - 0021-9258
AD  - Davis, D. A.: HIV and AIDS Malignancy Branch, NCI, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010649.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Registry Number: 70-18-8. 
N2  - Previous studies have suggested that the two conserved cysteines of the HIV-1 protease may be involved in regulating protease activity. This study examined diglutathionylated wild type protease (Cys-67-SSG, Cys-95-SSG) and the monoglutathionylated protease mutants (C67A, Cys-95-SSG and C95A, Cys-67-SSG) as potential substrates for thioltransferase (glutaredoxin). Glutathione alone was not a effective reductant, whereas thioltransferase displayed differential catalysis toward the Cys-95-SSG and Cys-67-SSG sites. At low thioltransferase concentrations (5nM), deglutathionylation occurred almost exclusively at Cys-95-SSG. With substantially more thioltransferase (100 nM) Cys-67-SSG was partially deglutationylated but only at 20% of the rate of Cys-95-SSG reduction. Treatment of the diglutathionylated protease with thioltransferase not only restored protease activity but generated an enzyme preparation that had a 3- to 5-fold greater specific activity relative to the fully reduced form. Immunoblot analysis of HIV-1MN virus with an antibody to thioltransferase detected a band co-migrating with recombinant thioltransferase that persisted following subtilisin treatment, indicating the presence of thioltransferase within HIV-1. These results implicate thioltransferase in the regulation and/or maintenance of protease activity in HIV-1 infected cells.
KW  - analysis
KW  - antibodies
KW  - biochemistry
KW  - catalytic activity
KW  - concentration
KW  - glutathione
KW  - HIV-1 infections
KW  - human diseases
KW  - immunoblotting
KW  - mutants
KW  - proteinases
KW  - regulation
KW  - substrates
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - proteases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010649&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma leptin responses to fasting in Pima Indians.
AU  - Pratley, R. E.
AU  - Nicolson, M.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1997///
VL  - 273
IS  - 3, 1
SP  - E644
EP  - E649
SN  - 0002-9513
AD  - Pratley, R. E.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19971411875.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9004-10-8, 169494-85-3.  Subject Subsets: Human Nutrition
N2  - This study examined the plasma leptin responses to a standard test meal and a subsequent 24-h fast in 231 healthy Pima Indians (35±2 years old), recruited from the Gila River Indian Community, USA, and then related these responses to changes in plasma insulin, selected metabolites and energy expenditure. Plasma leptin concentrations decreased by 8% (P&lt;0.05) 2-4 h after the test meal. They returned to baseline 6-12 h after the subjects ate, then subsequently decreased and, by the end of the fast, were an average of 37% below baseline (P&lt;0.0001). Changes in plasma leptin concentrations did not correlate with changes in plasma glucose, insulin, triglyceride or nonesterified fatty acid concentrations or with changes in metabolic rate. It was concluded that plasma leptin concentrations decrease in response to short-term energy restriction alone. It was suggested that the decrease in plasma leptin concentrations with fasting may be an important homeostatic response to an energy deficit, stimulating food intake and thus restoring energy balance.
KW  - blood
KW  - blood sugar
KW  - energy balance
KW  - ethnic groups
KW  - fasting
KW  - fatty acids
KW  - food intake
KW  - insulin
KW  - leptin
KW  - metabolism
KW  - obesity
KW  - responses
KW  - triacylglycerols
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood glucose
KW  - fatness
KW  - glucose in blood
KW  - triglycerides
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411875&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In search of AIDS-resistance genes.
AU  - O'Brien, S. J.
AU  - Dean, M.
JO  - Scientific American
JF  - Scientific American
Y1  - 1997///
VL  - 277
IS  - 3
SP  - 28
EP  - 35
SN  - 0036-8733
AD  - O'Brien, S. J.: Laboratory of Genomic Diversity, National Cancer Institute, USA.
N1  - Accession Number: 19972010160.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref.
N2  - This review examines the genetic factors that confer resistance against HIV-1. In particular, it focuses on the gene for the CCR5 receptor and the protective effect associated with homozygosity for the deletion mutant. Implications for treatment are discussed.
KW  - acquired immune deficiency syndrome
KW  - alleles
KW  - chemokines
KW  - cytokines
KW  - genes
KW  - HIV-1 infections
KW  - homozygosity
KW  - human diseases
KW  - immunology
KW  - pathogenesis
KW  - receptors
KW  - resistance
KW  - reviews
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - genetic susceptibility
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010160&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Therapeutic effect of combination antiretroviral therapy on cytomegalovirus retinitis.
AU  - Whitcup, S. M.
AU  - Fortin, E.
AU  - Nussenblatt, R. B.
AU  - Polis, M. A.
AU  - Muccioli, C.
AU  - Belfort, R., Jr.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1997///
VL  - 277
IS  - 19
SP  - 1519
EP  - 1520
SN  - 0098-7484
AD  - Whitcup, S. M.: National Eye Institute, Bethesda, MD, USA.
N1  - Accession Number: 19972007211.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - case reports
KW  - combination therapy
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - retinitis
KW  - treatment
KW  - cytomegalovirus
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - chemotherapy
KW  - combined modality therapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - multimodal treatment
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007211&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression.
AU  - Smith, M. W. (
AU  - et al.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1997///
VL  - 277
IS  - 5328
SP  - 959
EP  - 965
SN  - 0036-8075
AD  - Smith, M. W. (: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19972008574.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref.
N2  - The critical role of chemokine receptors (CCR5 and CXCR4) in HIV-1 infection and pathogenesis prompted a search for polymorphisms in other chemokine receptor genes that mediate HIV-1 disease progression. A mutation (CCR2-641) within the first transmembrane of the CCR2 chemokine and HIV-1 receptor gene is described that occurred at an allele frequency of 10 to 15% among Caucasians and African Americans. Genetic association analysis of 5 AIDS cohorts (3003 patients) revealed that although CCR2-641 exerts no influence on the incidence of HIV-1 infection, HIV-1-infected individuals carrying the CCR2-641 allele progressed to AIDS 2 to 4 years later than individuals homozygous for the common allele. Because CCR2-641 occurs invariably on a CCR5+-bearing chromosomal haplotype, the independent effects of CCR5-Δ32 (which also delays AIDS onset) and CCR2-641 were determined. An estimated 38 to 45% of AIDS patients whose disease progresses rapidly (less than 3 years until onset of AIDS symptoms after HIV-1 exposure) can be attributed to their CCR2-+/+ or CCR5-+/+ genotype, whereas the survival of 28 to 29% of long-term survivors, who avoid AIDS for 16 years or more, can be explained by a mutant genotype for CCR2 or CCR5. Editorial comment:This extremely interesting molecular epidemiological study now demonstrates that an additional variant of a chemokine receptor seems to be associated with slow progression to HIV-1-immune suppression. It has been previously shown by this and other groups that the CCR5 receptor heterologous and homozygous variant affected HIV-1 infection and in vivo replication. This new study demonstrates that the CCR2 gene may contain a mutation which favourably alters the clinical progression of HIV-1 infection in these individuals. As such, further studies will be necessary to correlate the growing number of chemokine receptors which may be associated with HIV-1 infection and transmission in vivo plus progression of disease.
KW  - acquired immune deficiency syndrome
KW  - chemokines
KW  - clinical aspects
KW  - genes
KW  - genotypes
KW  - immunology
KW  - receptors
KW  - transmembrane proteins
KW  - transmission
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - ccr2
KW  - ccr5
KW  - chemokine receptors
KW  - clinical picture
KW  - human immunodeficiency virus type 1
KW  - long term
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008574&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epstein-Barr virus and the immune system. Hide and seek.
AU  - Cohen, J. I.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1997///
VL  - 278
IS  - 6
SP  - 510
EP  - 513
SN  - 0098-7484
AD  - Cohen, J. I.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972008776.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Public Health
N2  - A case is presented of Epstein-Barr virus-associated Burkitt's lymphoma in a 35-year-old man from Maryland, USA. The pathogenesis of Epstein-Barr infection is discussed.
KW  - Burkitt's lymphoma
KW  - case reports
KW  - human diseases
KW  - immune system
KW  - infections
KW  - lymphoma
KW  - neoplasms
KW  - pathogenesis
KW  - viral diseases
KW  - Maryland
KW  - North America
KW  - USA
KW  - Human herpesvirus 4
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - epstein-barr virus
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008776&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The risk of bovine spongiform encephalopathy ('mad cow disease') to human health.
AU  - Brown, P.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1997///
VL  - 278
IS  - 12
SP  - 1008
EP  - 1011
SN  - 0098-7484
AD  - Brown, P.: Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
N1  - Accession Number: 19982208474.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Veterinary Science; Animal Nutrition
N2  - The link between human cases of new variant Creutzfeldt-Jakob disease in Britain and eating beef infected with the agent of bovine spongiform encephalopathy (BSE) is discussed, and reasons for and against the presumption are explained. The risk of a similar situation occurring in countries other than Britain, in particular the USA, is assessed in terms of the existence of scrapie (in sheep) or unrecognized BSE (in cattle), the practice of recycling non-edible sheep and cattle tissue as animal feed and precautionary measures already taken or under consideration by government agencies.
KW  - bovine spongiform encephalopathy
KW  - Creutzfeldt-Jakob disease
KW  - disease transmission
KW  - feeds
KW  - health
KW  - human diseases
KW  - prion diseases
KW  - public health
KW  - risk factors
KW  - scrapie
KW  - UK
KW  - USA
KW  - cattle
KW  - sheep
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Ovis
KW  - British Isles
KW  - Western Europe
KW  - Europe
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - APEC countries
KW  - North America
KW  - America
KW  - bovine encephalopathy
KW  - Britain
KW  - BSE
KW  - feeding stuffs
KW  - mad cow disease
KW  - United Kingdom
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982208474&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer incidence after retinoblastoma: radiation dose and sarcoma risk.
AU  - Wong, F. L.
AU  - Boice, J. D., Jr.
AU  - Abramson, D. H.
AU  - Tarone, R. E.
AU  - Kleinerman, R. A.
AU  - Stovall, M.
AU  - Goldman, M. B.
AU  - Seddon, J. M.
AU  - Tarbell, N.
AU  - Fraumeni, J. F., Jr.
AU  - Li, F. P.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1997///
VL  - 278
IS  - 15
SP  - 1262
EP  - 1267
SN  - 0098-7484
AD  - Wong, F. L.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982003541.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Public Health
N2  - The objective of this study was to examine the long-term risk of new primary neoplasms in survivors of childhood retinoblastoma and quantify the role of radiotherapy in sarcoma development. A cohort of 1604 patients with retinoblastoma identified from hospital records in Massachusetts and New York, USA between 1914 and 1984, who survived for ≥one year after diagnosis and were known to be alive in 1925 or later, were followed up. Follow-up began 1 year after diagnosis of retinoblastoma and ended at date of loss to follow-up (n=112, median duration=4.2 years), the date of death (n=330) or December 1993 (n=1162). Incidence of subsequent cancers (recorded on 2 occasions, between 1987 and 1988 and in 1993, during telephone interviews) was significantly elevated only in the 961 patients with hereditary retinoblastoma, in whom 190 cancers were diagnosed vs. 6.3 expected in the general population (relative risk [RR], 30; 95% confidence interval, 26-47). Cumulative incidence (±s.e.) of a second cancer at 50 years after diagnosis was 51.0% (±6.2%) for hereditary retinoblastoma and 5.0% (±3.0%) for non-hereditary retinoblastoma. All 114 sarcomas of diverse histological types occurred in patients with hereditary retinoblastoma. For soft tissue sarcomas, the RRs showed a stepwise increase at all dose categories and were significant between 10 and 29.9 Gy and between 30 and 59.9 Gy. A radiation risk for all sarcomas combined was evident at doses &gt;5 Gy, rising to 10.7-fold at doses of ≥60 Gy (P&lt;0.05). It is concluded that genetic predisposition has a substantial impact on risk of subsequent cancers in retinoblastoma patients, which is further increased by radiation treatment. This is the first reported demonstration of a radiation dose-response relationship in humans for soft tissue sarcomas. It is suggested that retinoblastoma patients should be examined for new cancers and followed into later life to determine whether their extraordinary cancer risk extends to common cancers of adulthood.
KW  - children
KW  - epidemiology
KW  - genetic factors
KW  - human diseases
KW  - incidence
KW  - neoplasms
KW  - predisposition
KW  - radiation
KW  - risk
KW  - risk factors
KW  - sarcoma
KW  - Massachusetts
KW  - New York
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Middle Atlantic States of USA
KW  - cancers
KW  - retinoblastoma
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003541&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rab 3D in rat adipose cells and its overexpression in genetic obesity (Zucker fatty rat).
AU  - Guerre-Millo, M.
AU  - Baldini, G.
AU  - Lodish, H. F.
AU  - Lavau, M.
AU  - Cushman, S. W.
JO  - Biochemical Journal (London)
JF  - Biochemical Journal (London)
Y1  - 1997///
VL  - 321
IS  - 1
SP  - 89
EP  - 93
SN  - 0264-6021
AD  - Guerre-Millo, M.: Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19971405039.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 50-99-7, 86-01-1, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - The subcellular distribution of Rab 3D, a member of the Rab 3 subfamily of low-molecular-mass GTP-binding proteins, in Sprague-Dawley rat adipose cells was examined, given the hypothesis that this protein might be involved in insulin-stimulated GLUT4 exocytosis. Rab 3D immunoreactivity was associated predominantly with the high-density microsomal fraction, where the signal intensity was 3- and 7-fold greater than that in plasma membranes and low-density microsomes respectively. Rab 3D did not co-localize with GLUT4 on immuno-isolated intracellular vesicles and, unlike GLUT4, it is not redistributed in response to insulin. Thus, if Rab 3D plays a role in GLUT4 trafficking, it relies on mechanisms independent of relocation. Rab 3D was overexpressed in adipose cells of obese (fa/fa) Zucker rats, in a tissue- and isoform-specific manner. The pathophysiological significance of this defect remains elusive. This could form the molecular basis for altered adipose secretory function in obesity.
KW  - adipocytes
KW  - adipose tissue
KW  - binding proteins
KW  - gene expression
KW  - glucose
KW  - guanosine triphosphate
KW  - insulin
KW  - microsomes
KW  - obesity
KW  - transporters
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - dextrose
KW  - fat cells
KW  - fatness
KW  - implement trailers
KW  - implement transporters
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405039&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS.
AU  - Sei, Y.
AU  - Nishida, K.
AU  - Kustova, Y.
AU  - Markey, S. P.
AU  - Morse, H. C., III
AU  - Basile, A. S.
JO  - European Journal of Pharmacology
JF  - European Journal of Pharmacology
Y1  - 1997///
VL  - 325
IS  - 1
SP  - 81
EP  - 84
SN  - 0014-2999
AD  - Sei, Y.: Laboratory of Neuroscience, NIDDK, Bldg 8, Rm 111, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972006250.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref.
N2  - Tumour necrosis factor-α (TNF-α) and platelet-activating factor (PAF) have been implicated in the pathogenesis of HIV-associated encephalopathy. The effects of pentoxifylline on brain PAF levels were examined in mice infected with the LP-BM5 murine leukaemia virus (MuLV). 7 weeks after viral inoculation , significant increases in serum TNF-α and brain PAF levels were observed. One week of treatment with pentoxifylline initiated 6 weeks post-infection significantly reduced both serum TNF-α and brain PAF levels. A significant positive correlation was observed between the levels of these substances (r=0.62; P&lt;0.01). This study demonstrated that pentoxifylline treatment was effective in decreasing the levels of TNF-α in the serum and PAF levels in the brain of mice infected with the LP-BM5 MuLV.
KW  - acquired immune deficiency syndrome
KW  - brain
KW  - immunomodulators
KW  - inoculation
KW  - leukaemia
KW  - necrosis
KW  - platelet activating factor
KW  - treatment
KW  - mice
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - blood cancer
KW  - cerebrum
KW  - leucaemia
KW  - leukemia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006250&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The treatment of chronic viral hepatitis.
AU  - Hoofnagle, J. H.
AU  - Bisceglie, A. M. di
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 336
IS  - 5
SP  - 347
EP  - 356
SN  - 0028-4793
AD  - Hoofnagle, J. H.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010396.  Publication Type: Journal Article.  Language: English.  Number of References: 106 ref. Registry Number: 9008-11-1.  Subject Subsets: Public Health
N2  - Drug therapy for chronic hepatitis B, hepatitis delta, and hepatitis C is reviewed, including clinical and serological features, therapy with interferon alpha, indications for therapy, indicators of a response to therapy, therapy of atypical forms and new approaches to therapy.
KW  - chronic infections
KW  - clinical aspects
KW  - drug therapy
KW  - hepatitis B
KW  - hepatitis C
KW  - hepatitis D
KW  - human diseases
KW  - interferon
KW  - reviews
KW  - serology
KW  - viral diseases
KW  - viral hepatitis
KW  - hepatitis B virus
KW  - hepatitis C virus
KW  - hepatitis delta virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Deltavirus
KW  - negative-sense ssRNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - clinical picture
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010396&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease.
AU  - Alter, H. J.
AU  - Nakatsuji, Y.
AU  - Melpolder, J.
AU  - Wages, J.
AU  - Wesley, R.
AU  - Shih, J. W. K.
AU  - Kim, J. P.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 336
IS  - 11
SP  - 747
EP  - 754
SN  - 0028-4793
AD  - Alter, H. J.: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972010188.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 9000-86-6.  Subject Subsets: Public Health
N2  - Serum samples collected in the USA in 1972-95 from 357 transfusion recipients, 157 controls who did not receive transfusions, 500 randomly selected blood donors, and 230 donors of blood received by hepatitis G virus (HGV)-infected patients were tested for HGV RNA by qualitative and quantitative polymerase-chain-reaction assays. Samples obtained before transfusion and serially after transfusion from 79 of 81 transfusion recipients who had transfusion-associated non-A, non-B hepatitis were also tested. Of the 79 patients with transfusion-associated hepatitis, 63 (80%) had infections related to the hepatitis C virus (HCV) and 3 had preexisting HCV and the cause of their acute hepatitis could not be determined; of the remaining 13 patients, 3 had acute HGV infection, and 10 were infected with unidentified agents. Six of the 63 patients with HCV infection who were tested (10%) were also infected with HGV. The 3 patients infected only with HGV had mild hepatitis (mean peak alanine aminotransferase concentration 198 U per litre; none had jaundice); the concentrations of alanine aminotransferase and HGV RNA were not well correlated. The combined HCV and HGV infections were no more severe than HCV infections alone; the alanine aminotransferase values paralleled the concentrations of HCV RNA, but not those of HGV RNA. There were 35 HGV infections among the 357 transfusion recipients; only 3 had hepatitis with HGV as the sole viral marker. One of the 157 controls and 7 of the 500 randomly selected blood donors (1.4%) had detectable HGV RNA. In all 8 instances in which a transfusion recipient had acute HGV infection after transfusion and samples from all donors could be tested, at least one HGV-positive donor was identified. It was concluded that HGV was common in a group of blood donors, and it can be transmitted by transfusion. Most HGV infections were not associated with hepatitis. HGV did not worsen the course of concurrent HCV infection. No causal relation between HGV and hepatitis has been established.
KW  - alanine aminotransferase
KW  - blood donors
KW  - blood transfusion
KW  - disease transmission
KW  - epidemiology
KW  - hepatitis
KW  - hepatitis C
KW  - human diseases
KW  - incidence
KW  - liver
KW  - liver diseases
KW  - pathogenesis
KW  - viral hepatitis
KW  - USA
KW  - hepatitis C virus
KW  - hepatitis G virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - gb virus
KW  - glutamate pyruvate transaminase
KW  - glutamic pyruvic transaminase
KW  - GPT
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010188&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Monoclonal origin of multicentric Kaposi's sarcoma lesions.
AU  - Rabkin, C. S.
AU  - Janz, S.
AU  - Lash, A.
AU  - Coleman, A. E.
AU  - Musaba, E.
AU  - Liotta, L.
AU  - Biggar, R. J.
AU  - Zhuang ZhengPing
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 336
IS  - 14
SP  - 988
EP  - 993
SN  - 0028-4793
AD  - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, EPN/434, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972004504.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
N2  - These data indicate that Kaposi's sarcoma is a disseminated monoclonal cancer and that the changes that permit the clonal outgrowth of spindle cells occur before the disease spreads.Editorial Comment:This interesting study adds to our understanding of the pathogenesis of KS. Presumably KSHV (HHV-8) somehow induces a clonal transformation of spindle cells which proliferate into a tumour. The key question is how to prevent acquisition of this viral infection and to treat it before KS develops.
KW  - aetiology
KW  - clinical aspects
KW  - clones
KW  - disseminated infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - infections
KW  - Kaposi's sarcoma
KW  - monoclonal antibodies
KW  - neoplasms
KW  - pathogenesis
KW  - sarcoma
KW  - viral diseases
KW  - Herpesviridae
KW  - human herpesvirus 8
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Herpesviridae
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - causal agents
KW  - clinical picture
KW  - etiology
KW  - human immunodeficiency virus
KW  - spindle cells
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004504&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
AU  - Struewing, J. P.
AU  - Hartge, P.
AU  - Wacholder, S.
AU  - Baker, S. M.
AU  - Berlin, M.
AU  - McAdams, M.
AU  - Timmerman, M. M.
AU  - Brody, L. C.
AU  - Tucker, M. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 336
IS  - 20
SP  - 1401
EP  - 1408
SN  - 0028-4793
AD  - Struewing, J. P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19972010064.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Public Health
N2  - Blood samples were collected from 5318 Jewish men and women from Washington DC, USA, who had filled out epidemiological questionnaires [date not given]. Carriers of the 185delAG and 5382insC mutations in BRCA1 and the 6174delT mutation in BRCA2 were identified with assays based on the polymerase chain reaction. The risks of breast and other cancers were estimated by comparing the cancer histories of relatives of carriers of the mutations and noncarriers. 120 carriers of a BRCA1 or BRCA2 mutation were identified. By the age of 70, among carriers, the estimated risk of breast cancer was 56% (95% confidence interval, 40-73%), the estimated risk of ovarian cancer was 16% (95% confidence interval, 6-28%) and the estimated risk of prostate cancer, 16% (95% confidence interval, 4-30%). There were no significant differences in the risk of breast cancer between carriers of BRCA1 mutations and carriers of BRCA2 mutations and the incidence of colon cancer among the relatives of carriers was not elevated. It is concluded that &gt;2% of Ashkenazi Jews carry mutations in BRCA1 or BRCA2 that confer increased risks of breast, ovarian and prostate cancer. The risks of breast cancer may be overestimated, but they fall well below previous estimates based on subjects from high-risk families.
KW  - breast cancer
KW  - carriers
KW  - epidemiology
KW  - ethnic groups
KW  - genetic factors
KW  - genotypes
KW  - human diseases
KW  - mutations
KW  - neoplasms
KW  - ovaries
KW  - prostate
KW  - risk
KW  - risk factors
KW  - District of Columbia
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma.
AU  - Blauvelt, A.\Herndier, B. G.\Orenstein, J. M.\Friborg, J., Jr.\Nabel, G. J.\Nickoloff, B. J.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 336
IS  - 25
SP  - 1837
EP  - 1839
SN  - 0028-4793
AD  - National Cancer Institute, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19972006228.  Publication Type: Correspondence.  Language: English.  Number of References: 5 ref.
KW  - acquired immune deficiency syndrome
KW  - epidemiology
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - kaposi's sarcoma
KW  - Herpesviridae
KW  - human herpesvirus 8
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Herpesviridae
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Residential exposure to magnetic fields and acute lymphoblastic leukemia in children.
AU  - Linet, M. S.
AU  - Hatch, E. E.
AU  - Kleinerman, R. A.
AU  - Robison, L. L.
AU  - Kaune, W. T.
AU  - Friedman, D. R.
AU  - Severson, R. K.
AU  - Haines, C. M.
AU  - Hartsock, C. T.
AU  - Niwa, S.
AU  - Wacholder, S.
AU  - Tarone, R. E.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 337
IS  - 1
SP  - 1
EP  - 7
SN  - 0028-4793
AD  - Linet, M. S.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Suite 408, Bethesda, MD 20892-7362, USA.
N1  - Accession Number: 19972008101.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Public Health
N2  - Previous studies found associations between childhood leukaemia and surrogate indicators of exposure to magnetic fields (the power-line classification scheme known as "wire coding"), but not between childhood leukaemia and measurements of 60-Hz residential magnetic fields. 638 children with acute lymphoblastic leukaemia (ALL) who were under 15 years of age and were registered with the Children's Cancer Group and 620 controls were enrolled in a study in the USA of residential exposure to magnetic fields generated by nearby power lines. In the subjects' current and former homes, data collectors blinded to the subjects' health status measured magnetic fields for 24 hours in each child's bedroom and for 30 seconds in three or four other rooms and outside the front door. A computer algorithm assigned wire-code categories, based on the distance and configuration of nearby power lines, to the subjects' main residences (for 416 case patients and 416 controls) and to those where the family had lived during the mother's pregnancy with the subject (for 230 case patients and 230 controls). The risk of childhood ALL was not linked to summary time-weighted average residential magnetic-field levels, categorized according to a priori criteria. The odds ratio for ALL was 1.24 (95% confidence interval, 0.86 to 1.79) at exposures of 0.200 µT or greater as compared with less than 0.065 µT. The risk of ALL was not increased among children whose main residences were in the highest wire-code category (odds ratio as compared with the lowest category, 0.88; 95% confidence interval, 0.48 to 1.63). Furthermore, the risk was not significantly associated with either residential magnetic-field levels or the wire codes of the homes mothers resided in when pregnant with the subjects. These results provide little evidence that living in homes characterized by high measured time-weighted average magnetic-field levels or by the highest wire-code category increases the risk of ALL in children.
KW  - algorithms
KW  - children
KW  - classification
KW  - dwellings
KW  - exposure
KW  - human diseases
KW  - indicators
KW  - leukaemia
KW  - magnetic field
KW  - neoplasms
KW  - radiation
KW  - risk factors
KW  - North America
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - acute lymphoblastic leukaemia
KW  - blood cancer
KW  - cancers
KW  - human health
KW  - leucaemia
KW  - leukemia
KW  - United States of America
KW  - Human Reproduction and Development (VV060) 
KW  - Human Health and the Environment (VV500) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008101&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trial of calcium to prevent preeclampsia.
AU  - Levine, R. J.
AU  - Hauth, J. C.
AU  - Curet, L. B.
AU  - Sibai, B. M.
AU  - Catalano, P. M.
AU  - Morris, C. D.
AU  - Simonian, R. der
AU  - Esterlitz, J. R.
AU  - Raymond, E. G.
AU  - Bild, D. E.
AU  - Clemens, J. D.
AU  - Cutler, J. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 337
IS  - 2
SP  - 69
EP  - 76
SN  - 0028-4793
AD  - Levine, R. J.: Division of Epidemiology, Statistics and Prevention Research, National Institutes of Health, Bldg. 6100, Rm. 7B03, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19971410969.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 7440-70-2.  Subject Subsets: Human Nutrition
N2  - 4589 healthy nulliparous women who were 13-21 weeks pregnant were randomly assigned to receive elemental Ca 2 g/day or placebo for the remainder of their pregnancies. Surveillance for preeclampsia was conducted by personnel unaware of treatment-group assignments, using standardized measurements of blood pressure and urinary protein excretion at uniformly scheduled prenatal visits, protocols for monitoring these measurements during the hospitalization for delivery and reviews of medical records of unscheduled outpatient visits and all hospitalizations. Ca supplementation did not significantly reduce the incidence or severity of preeclampsia or delay its onset. Preeclampsia occurred in 158 of the 2295 women in the Ca group (6.9%) and 168 of the 2294 women in the placebo group (7.3%) (relative risk, 0.94; 95% confidence interval, 0.76-1.16). There were no significant differences between the 2 groups in the prevalence of pregnancy-associated hypertension without preeclampsia (15.3% vs. 17.3%) or of all hypertensive disorders (22.2% vs. 24.6%). The mean systolic and diastolic blood pressures during pregnancy were similar in both groups. Ca did not reduce the numbers of preterm deliveries, small-for-gestational-age births, or fetal and neonatal deaths; nor did it increase urolithiasis during pregnancy.
KW  - blood pressure
KW  - calcium
KW  - fetal death
KW  - hypertension
KW  - infants
KW  - minerals
KW  - neonatal mortality
KW  - preeclampsia
KW  - pregnancy
KW  - premature infants
KW  - supplements
KW  - urolithiasis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calcium supplements
KW  - foetal death
KW  - gestation
KW  - high blood pressure
KW  - Physiology of Human Nutrition (VV120) 
KW  - Human Reproduction and Development (VV060) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410969&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis.
AU  - Wilson, P. W. F.
AU  - Hoeg, J. M.
AU  - D'Agostino, R. B.
AU  - Silbershatz, H.
AU  - Belanger, A. M.
AU  - Poehlmann, H.
AU  - O'Leary, D.
AU  - Wolf, P. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 337
IS  - 8
SP  - 516
EP  - 522
SN  - 0028-4793
AD  - Wilson, P. W. F.: Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
N1  - Accession Number: 19981401923.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - Cross-sectional and longitudinal information from 429 men and 661 women in the Framingham Heart Study in the USA was studied. These subjects underwent B-mode ultrasound measurements of the carotid artery. Their mean age was 75 years, and each had attended most of the biennial clinic examinations over the 34 years before the carotid ultrasound study. Time-integrated measurements were used to assess the associations between various cardiovascular risk factors and the degree of carotid stenosis. Moderate carotid stenosis (≥25%) was present in 189 men and 226 women. The odds ratios for this degree of stenosis was compared with minimal stenosis (&lt;25%) according to increases in risk factors. In the men, the odds ratio for moderate carotid stenosis associated with an increase of 20 mmHg in systolic blood pressure was 2.11 (95% confidence interval, 1.51-2.97). The odds ratio for an increase of 10 mg/100 ml (0.26 mmol/litre) in the cholesterol level was 1.10 (95% confidence interval, 1.03 to 1.16), and for an increase of 5 pack-years of smoking it was 1.08 (95% confidence interval, 1.03-1.13). The results were similar in the women. Time-integrated measurements of diastolic blood pressure showed significant associations with carotid stenosis in men and insignificant associations in women. It is concluded that over the long term, high systolic blood pressure, high cholesterol levels and smoking were associated with an increased risk of carotid stenosis in this elderly population.
KW  - blood
KW  - blood pressure
KW  - cardiovascular diseases
KW  - cholesterol
KW  - men
KW  - old age
KW  - risk factors
KW  - stenosis
KW  - tobacco smoking
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401923&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ethical complexities of conducting research in developing countries.
AU  - Varmus, H.
AU  - Satcher, D.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 337
IS  - 14
SP  - 1003
EP  - 1005
SN  - 0028-4793
AD  - Varmus, H.: National Institutes of Health, Bethesda, MD 20892-0148, USA.
N1  - Accession Number: 19972009881.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref.
N2  - The most compelling reason to use a placebo-controlled study is that it provides definitive answers to questions about the safety and value of an intervention in the setting in which the study is performed, and these answers are the point of the research. Without clear and firm answers to whether and, if so, how well an intervention works, it is impossible for a country to make a sound judgment about the appropriateness and financial feasibility of providing the intervention. If the affordable intervention is less effective than the ACTG 076 regimen-not an unlikely outcome-this information will be of little use in a country where the more effective regimen is unavailable. Equally important, it will still be unclear whether the affordable intervention is better than nothing and worth the investment of scarce health care dollars. Such studies would fail to meet the goal of determining whether a treatment that could be implemented is worth implementing. A placebo-controlled trial is not the only way to study a new intervention, but as compared with other approaches, it offers more definitive answers and a clearer view of side effects.
KW  - acquired immune deficiency syndrome
KW  - clinical trials
KW  - drug therapy
KW  - efficacy
KW  - ethics
KW  - evaluation
KW  - feasibility studies
KW  - health care
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - information
KW  - intervention
KW  - investment
KW  - prevention
KW  - regimens
KW  - research
KW  - safety
KW  - sociology
KW  - transmission
KW  - treatment
KW  - Developing countries
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - countries
KW  - AIDS
KW  - capital outlay
KW  - chemotherapy
KW  - ethics and human rights
KW  - feasibility
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - social aspects
KW  - studies
KW  - Third World
KW  - Underdeveloped Countries
KW  - Health Services (UU350) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Chemotherapy for AIDS-related lymphomas.
AU  - Wilson, W. H.
AU  - Sparano, J.\Straus, D. J.\Testa, M. A.\Kaplan, L. D.
T2  - New England Journal of Medicine
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 337
IS  - 16
SP  - 1172
EP  - 1174
SN  - 0028-4793
AD  - Wilson, W. H.: National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972009901.  Publication Type: Correspondence.  Language: English.  Number of References: 9 ref.
N2  - Both Wilson and Sparano take issue with Kaplan et al. (New England Journal of Medicine (1997) 336 1641) that low-dose chemotherapy is the preferred treatment for AIDS patients with non-Hodgkin's lymphoma. Both cite cases where more aggressive chemotherapy was effective. Kaplan et al. agree that there might be exceptions, but insist that low-dose chemotherapy is effective in many patients who cannot tolerate a more toxic dose level.
KW  - acquired immune deficiency syndrome
KW  - antineoplastic agents
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphoma
KW  - neoplasms
KW  - non-Hodgkin's lymphoma
KW  - patients
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cancers
KW  - chemotherapy
KW  - cytotoxic agents
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Postexposure treatment of HIV-Taking some risks for safety's sake.
AU  - Henderson, D. K.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997///
VL  - 337
IS  - 21
SP  - 1542
EP  - 1543
SN  - 0028-4793
AD  - Henderson, D. K.: National Institutes of Health Clinical Center, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982000437.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref.
N2  - The consequences of administering potentially toxic antiretroviral agents as chemoprophylaxis are serious. Conversely, the consequences associated with not offering treatment, the possibility of an increased risk of occupational HIV infection, were and remain at least as serious. The data presented by Cardo, D. M. (et al.) [New England Journal of Medicine (1997) 337, 1485] provide additional evidence that chemoprophylaxis may well be worthwhile after occupational exposure and may be a reasonable option after any type of exposure to HIV.
KW  - antiviral agents
KW  - chemoprophylaxis
KW  - drug therapy
KW  - exposure
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - occupational hazards
KW  - prophylaxis
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000437&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA.
AU  - Goedert, J. J.
AU  - Kedes, D. H.
AU  - Ganem, D.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
VL  - 349
IS  - 9062
SP  - 1368
EP  - 1368
SN  - 0140-6736
AD  - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, Rockville MD 20852, USA.
N1  - Accession Number: 19972005349.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref.
N2  - Of the 289 pregnant women, 12 (4.2%) were seropositive for anti-HHV8. This proportion is in good agreement with findings in high-risk non-pregnant women, in whom a prevalence of 3.4% was found. The present cohort included 91 women of Haitian origin. Based on earlier work indicating a higher prevalence of Kaposi's sarcoma in Haitian-born heterosexuals with AIDS compared with those born in the USA (6.3% vs 1.8%), the prevalence of HHV8 seropositivity was tested in this subgroup. Nine (10%) of 91 Haitian women were positive, significantly higher than the proportion (3/198, 1.5%) among other women (P=0.002, two-tailed Fisher's exact test). HHV8 seropositivity was not increased in women with HIV-1 infection, either among Haitian (1/28, 3.6%) or non-Haitian (2/118, 1.7%) women. All 189 infants were seronegative for HHV8, including 26 who were infected with HIV-1. Notably, none of the 9 children born to HHV8-seropositive mothers was HHV8-seropositive when tested at a median age of 12 months.
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - children
KW  - epidemiology
KW  - heterosexuality
KW  - HIV-1 infections
KW  - human diseases
KW  - immune response
KW  - infants
KW  - Kaposi's sarcoma
KW  - mothers
KW  - pregnancy
KW  - women
KW  - Haiti
KW  - USA
KW  - Herpesviridae
KW  - Human herpesvirus 4
KW  - human herpesvirus 8
KW  - Human immunodeficiency virus 1
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - Rhadinovirus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - Caribbean Community
KW  - Hispaniola
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Least Developed Countries
KW  - Developing Countries
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AIDS
KW  - Epstein-Barr virus
KW  - gestation
KW  - heterosexuals
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
KW  - Women (UU500) 
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hidden dangers of incompletely suppressive antiretroviral therapy.
AU  - Feinberg, M.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
VL  - 349
IS  - 9063
SP  - 1408
EP  - 1409
SN  - 0140-6736
AD  - Feinberg, M.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19972005990.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref.
N2  - Several important principles can be used to guide the choice of antiretroviral therapy. First, it is likely that HIV variants resistant to one or more drugs are already present in untreated patients. Second, the likelihood that drug-resistant variants are already present in an HIV-infected patient decreases as the number of non-cross-resistant antiretroviral drugs used in combination is increased. Third, in untreated patients the prevalence of HIV variants with high-level drug resistance through multiple mutations is also expected to decline as the number of mutations required for such resistance increases. (The need for multiple mutations to confer high-level resistance is seen with certain protease inhibitors such as ritonavir and indinavir.) Fourth, incomplete suppression of HIV replication will offer the opportunity for accumulation during continuing therapy of mutations that result in high-level drug resistance to even the most potent drugs available.
KW  - antiviral agents
KW  - clinical trials
KW  - drug resistance
KW  - drugs
KW  - human immunodeficiency viruses
KW  - inhibitors
KW  - mutations
KW  - proteinase inhibitors
KW  - proteinases
KW  - replication
KW  - resistance
KW  - treatment
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - medicines
KW  - pharmaceuticals
KW  - protease inhibitors
KW  - proteases
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005990&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians.
AU  - Pettitt, D. J.
AU  - Forman, M. R.
AU  - Hanson, R. L.
AU  - Knowler, W. C.
AU  - Bennett, P. H.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
VL  - 350
IS  - 9072
SP  - 166
EP  - 168
SN  - 0140-6736
AD  - Pettitt, D. J.: Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85014, USA.
N1  - Accession Number: 19970404019.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Dairy Science; Human Nutrition
N2  - Infant feeding data for the first 2 months of life were obtained from a questionnaire given to mothers of 720 Pima Indians, 10-39 years old. Height and weight were measured and subjects were subjected to a 75 g oral glucose tolerance test. 325 subjects who were exclusively bottle-fed had higher age- and sex-adjusted mean relative weights (146%) than 144 who were exclusively breast-fed (140%) or 251 who were partially breast fed (139%) (P=0.019). Subjects who were exclusively breast-fed had lower rates of non-insulin dependent diabetes mellitus (NIDDM) than those who were exclusively bottle-fed in all age groups (age 10-19, 0 of 56 vs. 6 of 165 (3.6%), age 20-29, 5 of 58 (8.6%) vs. 17 of 116 (14.7%), age 30-39, 6 of 30 (20.0%) vs. 13 of 44 (29.6%)). The odds ratio for NIDDM in exclusively breast-fed subjects, compared with those exclusively bottle-fed, was 0.41 (95% confidence interval 0.18-0.93) adjusted for age, sex, birth date, parental diabetes and birthweight. It is concluded that exclusive breast feeding for the first 2 months of life is associated with a reduced risk of NIDDM in Pima Indians. The increase in prevalence of NIDDM in some populations may be due to the concomitant decrease in breast feeding.
KW  - body weight
KW  - breast feeding
KW  - children
KW  - diabetes
KW  - diabetes mellitus
KW  - ethnic groups
KW  - glucose tolerance test
KW  - incidence
KW  - infant feeding
KW  - infants
KW  - men
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Structure (UU480) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues.
AU  - Rothman, N.
AU  - Cantor, K. P.
AU  - Blair, A.
AU  - Bush, D.
AU  - Brock, J. W.
AU  - Helzlsouer, K.
AU  - Zahm, S. H.
AU  - Needham, L. L.
AU  - Pearson, G. R.
AU  - Hoover, R. N.
AU  - Comstock, G. W.
AU  - Strickland, P. T.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
VL  - 350
IS  - 9073
SP  - 240
EP  - 244
SN  - 0140-6736
AD  - Rothman, N.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980502383.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 50-29-3.  Subject Subsets: Medical & Veterinary Entomology; Public Health; Agricultural Entomology
N2  - The steady worldwide increase in the incidence of non-Hodgkin lymphoma (NHL) during the past few decades remains mostly unexplained. Several studies suggest that there may be an association between the agricultural use of DDT and increased risk of NHL. The authors investigated the association between risk of NHL and body burden of selected organochlorines (OCs) in the general population in a nested case-control study. Prediagnostic serum concentrations of DDT, its metabolites and others OC, including polychlorinated biphenyls (PCBs), were measured in 74 cases of NHL and 147 matched controls identified from a prospective cohort of 25 802 adults, established in Washington County, Maryland, USA. There was a strong dose-response relation between quartiles of total lipid-corrected serum PCB concentrations and risk of NHL overall (odds ratio by quartile: 1.0; 1.3 (95% CI 0.5-3.3); 2.8 (1.1-7.6); and 4.5 (1.7-12.0); P for trend = 0.0008) and separately in men and in women. There was also evidence suggesting that seropositivity for Epstein-Barr virus early antigen potentiated the effects of serum PCBs. By contrast, total lipid-corrected serum concentrations of DDT were not associated with risk of NHL. The authors counsel caution with the interpretation of these results.
KW  - agricultural entomology
KW  - DDT
KW  - epidemiology
KW  - insecticide residues
KW  - lipids
KW  - lymphoma
KW  - metabolites
KW  - non-Hodgkin's lymphoma
KW  - nontarget effects
KW  - organochlorine compounds
KW  - organochlorine insecticides
KW  - pesticide residues
KW  - pesticides
KW  - polychlorinated biphenyls
KW  - residues
KW  - serum
KW  - Maryland
KW  - USA
KW  - Human herpesvirus 4
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - dicophane
KW  - Epstein-Barr virus
KW  - lipins
KW  - organic chlorine compounds
KW  - PCBs
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Health and the Environment (VV500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - CCR5-Δ32 gene deletion in HIV-1 infected patients.
AU  - Smith, M. W.
AU  - Dean, M.
AU  - Carrington, M.
AU  - Huttley, G. A.
AU  - O'Brien, S. J.
AU  - Michael, N. L.\Louie, L. G.\Sheppard, H. W.\Garred, P.\Eugen-Olsen, J.\Iversen, A. K. N.\Benfield, T. L.\Svejgaard, A.\Copenhagen AIDS Study Group\Wang, B.\Palasanthiran, P.\Zeigler, J.\Cunningham, A.\Saksena, N. K.
T2  - Lancet (British edition)
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
VL  - 350
IS  - 9079
SP  - 741
EP  - 742
SN  - 0140-6736
AD  - Smith, M. W.: Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19972008583.  Publication Type: Correspondence.  Language: English.  Number of References: 9 ref.
N2  - P Garred (et al.) [Lancet (1997) 349, 1884] present a survival analysis of a cohort including 99 HIV-1 exposed Danish homosexuals, which suggested that individuals heterozygous for a 32 base-pair deletion of the CCR5 receptor gene (CCR5Δ32) progress to death more rapidly after AIDS diagnosis than do homozygous wild-type individuals. The authors' study included 210 CCR5Δ32/+ heterozygotes who were indistinguishable from 949 CCR5-+/+ homozygotes in progression to death once AIDS was diagnosed. The observed tendency, although not significant, was for CCR5-+/Δ32 individuals to progress more slowly to death than CCR5-+/+ patients. Their conclusion is that the CCR5-Δ32 mediated postponement of AIDS pathology has been confirmed, but that the proposed association of CCR5-+/Δ32 genotype with rapid decline to death after a diagnosis of AIDS has been made was not confirmed.
KW  - acquired immune deficiency syndrome
KW  - chemokines
KW  - genotypes
KW  - immunology
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - ccr5
KW  - chemokine
KW  - chemokine receptors
KW  - gene deletion
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - "Love's labours lost": failure to implement mass vaccination against group A meningococcal meningitis in sub-Saharan Africa.
AU  - Robbins, J. B.
AU  - Towne, D. W.
AU  - Gotschlich, E. C.
AU  - Schneerson, R.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
VL  - 350
IS  - 9081
SP  - 880
EP  - 882
SN  - 0140-6736
AD  - Robbins, J. B.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2720, USA.
N1  - Accession Number: 19982005963.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Tropical Diseases
N2  - The reasons why, despite the effectiveness, safety, stability and cheapness of the group A meningococcal capsular polysaccharide vaccine, another epidemic of group A meningococcal meningitis occurred in sub-Saharan Africa in 1996 are discussed. The immunological properties of the group A vaccine (as well as those of the group B and C vaccines) are discussed, and clinical trials (carried out in sub-Saharan Africa) which demonstrate the vaccine's efficacy are reported. The details of group A meningococcal meningitis epidemics in Nigeria (in 1979), Rwanda (1980) and Mali (1981) are given, and the failure of selective vaccination programmes to prevent such epidemics is discussed. It is suggested that group A meningococcal epidemic prevention and eradication could be achieved by mass vaccination of the entire population. The fact that clinical agencies in sub-Saharan Africa favoured selective vaccination over mass vaccination is thought to be the cause of the 1996 epidemic.
KW  - bacterial diseases
KW  - bacterial meningitis
KW  - children
KW  - disease control
KW  - disease prevention
KW  - epidemics
KW  - human diseases
KW  - immunization
KW  - meningitis
KW  - outbreaks
KW  - vaccination
KW  - Africa
KW  - Africa South of Sahara
KW  - man
KW  - Neisseria meningitidis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Neisseria
KW  - Neisseriaceae
KW  - Neisseriales
KW  - Betaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Africa
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - immune sensitization
KW  - Meningococcus
KW  - subsaharan Africa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005963&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antigenic variation in Giardia lamblia and the host's immune response.
AU  - Nash, T. E.
A2  - F.Y. Liew
A2  - K. Vickerman.
JO  - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
JF  - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Y1  - 1997///
VL  - 352
IS  - 1359
SP  - 1369
EP  - 1375
SN  - 0962-8436
AD  - Nash, T. E.: Laboratory of Parasitic Diseases, Gastrointestinal Parasites Section, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980800377.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Protozoology
N2  - Antigenic variation in Giardia lamblia [G. duodenalis] is reviewed. The antigens involved belong to a family of variant-specific surface proteins (VSPs) which are unique, cysteine-rich zinc finger proteins. Changes in VSP expression occur within the population in vivo owing to selection of VSPs by both immune and non-immune mechanisms. After inoculation of a single G. lamblia clone (able to persist in the absence of immune pressure) expressing one VSP (≥90%) into mice or humans, the original VSP continues to be expressed until 2 weeks pi, when other VSPs gradually replace it. Selection by immune-mediated processes is suggested because switching occurs at the same time that humoral responses are first detected. Almost all trophozoites are eliminated at 3 weeks pi but a barely detectable infection persists over months. In neonatal mice, apparent self-cure is delayed until 6 or 7 weeks pi. Antigenic switching does not occur in adult or immunodeficient (SCID) mice but does occur in neonatal nude mice, implicating B-cell-mediated mechanisms in immune switching. Not all VSPs are expressed to the same degree in vivo. The purpose of antigenic variation may be presentation of a wide assortment of VSPs to hosts, increasing the chance of a successful initial infection or reinfection. Immune selection of variants comes into play following biological selection.
KW  - antigenic variation
KW  - antigens
KW  - B lymphocytes
KW  - immune response
KW  - parasites
KW  - proteins
KW  - reviews
KW  - selection
KW  - surface proteins
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - B cells
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - membrane proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Metabolism of food-derived heterocyclic amines in nonhuman primates.
AU  - Snyderwine, E. G.
AU  - Turesky, R. J.
AU  - Turteltaub, K. W.
AU  - Davis, C. D.
AU  - Sadrieh, N.
AU  - Schut, H. A. J.
AU  - Nagao, M.
AU  - Sugimura, T.
AU  - Thorgeirsson, U. P.
AU  - Adamson, R. H.
AU  - Thorgeirsson, S. S.
JO  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1  - 1997///
VL  - 376
IS  - 1/2
SP  - 203
EP  - 210
SN  - 0027-5107
AD  - Snyderwine, E. G.: Laboratory of Experimental Carcinogenesis, Building 37, Room 3C28, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19981406026.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
KW  - amines
KW  - carcinogens
KW  - cooking
KW  - foods
KW  - heterocyclic nitrogen compounds
KW  - metabolism
KW  - mutagens
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pirated genes in Kaposi's sarcoma.
AU  - Murphy, P. M.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1997///
VL  - 385
IS  - 6614
SP  - 296
EP  - 299
SN  - 0028-0836
AD  - Murphy, P. M.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N113, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972003525.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref.
KW  - acquired immune deficiency syndrome
KW  - chemokines
KW  - genes
KW  - HIV-1 infections
KW  - human diseases
KW  - kaposi's sarcoma
KW  - neoplasms
KW  - oncogenes
KW  - pathogenesis
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - cancers
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003525&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - A new SIV co-receptor, STRL33.
AU  - Alkhatib, G.
AU  - Liao Fang
AU  - Berger, E. A.
AU  - Farber, J. M.
AU  - Peden, K. W. C.
T2  - Nature (London)
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1997///
VL  - 388
IS  - 6639
SP  - 238
EP  - 238
SN  - 0028-0836
AD  - Alkhatib, G.: Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19972006810.  Publication Type: Correspondence.  Language: English.  Number of References: 18 ref.
N2  - It is reported that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms, is a co-receptor for SIV. Together with a previous report that STRL33 functions with HIV-1 strains of diverse tropisms [Liao, F. (et al.) Journal of Experimental Medicine (1997), 185, 2015], these results with SIV demonstrate that STRL33 is active with a broader range of Envs than has been described for any of the co-receptors so far discovered. This attribute suggests that STRL33 will be of particular value in unravelling the structural determinants of interactions between Envs and co-receptors.
KW  - chemokines
KW  - hiv infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - simian immunodeficiency virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006810&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Molecular assessment of the potential transmissibilities of BSE and scrapie to humans.
AU  - Raymond, G. J.
AU  - Hope, J.
AU  - Kocisko, D. A.
AU  - Priola, S. A.
AU  - Raymond, L. D.
AU  - Bossers, A.
AU  - Ironside, J.
AU  - Will, R. G.
AU  - Chen, S. G.
AU  - Petersen, R. B.
AU  - Gambetti, P.
AU  - Rubenstein, R.
AU  - Smits, M. A.
AU  - Lansbury, P. T., Jr.
AU  - Caughey, B.
T2  - Nature (London)
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1997///
VL  - 388
IS  - 6639
SP  - 285
EP  - 288
SN  - 0028-0836
AD  - Raymond, G. J.: Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19982206967.  Publication Type: Correspondence.  Language: English.  Number of References: 26 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - In bovine spongiform encephalopathy (BSE) and other transmissible spongiform encephalopathy (TSE) diseases, the conversion of the protease-sensitive host prion protein (PrP-sen) to a protease-resistant isoform (PrP-res) is an important event in pathogenesis. Biological aspects of TSE diseases are reflected in the specificities of in vitro PrP conversion reactions. This experiment showed that there is a correlation between in vitro conversion efficiencies and known transmissibilities of BSE, sheep scrapie and CJD. On this basis, an in vitro system was used to gauge the potential transmissibility of scrapie and BSE to humans. Limited conversion of human PrP-sen to Prp-res driven by PrP-res associated with both scrapie (PrPSc) and BSE (PrPBSE) was found. The efficiencies of these heterologous conversion reactions were similar but much lower than those of relevant homologous conversions. Thus the inherent ability of these infectious agents of BSE and scrapie to affect humans following equivalent exposure may be finite but similarly low.
KW  - assessment
KW  - bovine spongiform encephalopathy
KW  - Creutzfeldt-Jakob disease
KW  - disease transmission
KW  - human diseases
KW  - prion diseases
KW  - scrapie
KW  - zoonoses
KW  - man
KW  - sheep
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Ovis
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - bovine encephalopathy
KW  - BSE
KW  - mad cow disease
KW  - zoonotic infections
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982206967&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor.
AU  - Weissman, D.
AU  - Rabin, R. L.
AU  - Arthos, J.
AU  - Rubbert, A.
AU  - Dybul, M.
AU  - Swofford, R.
AU  - Venkatesan, S.
AU  - Farber, J. M.
AU  - Fauci, A. S.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1997///
VL  - 389
IS  - 6654
SP  - 981
EP  - 985
SN  - 0028-0836
AD  - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892,USA Correspondence address[Weissman, D.]:Division of Infectious Diseases, University of Pennsylvania Medical Center, 536 Johnson Pavillion, Philadelphia, PA 19104, USA.
N1  - Accession Number: 19972010816.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref.
N2  - This study shows that recombinant envelope proteins from macrophage-tropic HIV and SIV induce a signal through CCR5 on CD4+ T cells and that envelope-mediated signal transduction through CCR5 induces chemotaxis of T cells. This chemotactic response may contribute to the pathogenesis of HIV in vivo by chemo-attracting activated CD4+ cells to sites of viral replication. HIV-mediated signalling through CCR5 may also enhance viral replication in vivo by increasing the activation state of target cells. Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis. Editorial comment:The present study and those of Pal, et al. (Science (1997) 278 695), and Michael et al. (Nature Medicine (1997) 3 1160), are critical in dissecting the further complexity of chemokine and chemokine receptor interactions with HIV-1 infection. In the interesting study by Weissman, et al., it is shown that macrophagetropic HIV-1 and SIV envelopes can induce signaling through the CCR5 chemokine receptor. This increase in signal transduction leads to the chemo-attraction of activated CD4+ cells. As such, this may be an important mechanism by which uninfected cells are brought to virally-infected areas in vivo. The paper by Pal, et al. is interesting in that it demonstrates a new chemokine receptor from macrophages which seems to be very important in suppressing HIV-1 expression in primary T lymphocytes. Its utility in therapy will require further studies. Finally, the paper by Michael et al. seems to contradict a previous study that a mutation in the transmembrane domain of CCR5, entitled CCR2B (641), does not inhibit HIV-1 disease progression in vivo. This is contrary to the work by Smith et al. (Science (1997) 277 959).
KW  - CD4+ lymphocytes
KW  - chemokines
KW  - chemotaxis
KW  - cytokines
KW  - cytopathogenicity
KW  - disease course
KW  - envelope proteins
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - macrophages
KW  - mutations
KW  - pathogenesis
KW  - proteins
KW  - receptors
KW  - replication
KW  - responses
KW  - T lymphocytes
KW  - transmembrane proteins
KW  - tropisms
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - simian immunodeficiency virus
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - CD4+ cells
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - T4 lymphocytes
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010816&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of fat intake on energy balance.
AU  - Tataranni, P. A.
AU  - Ravussin, E.
A2  - Anderson, G. H.
A2  - Rolls, B. J.
A2  - Steffen, D. G.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1997///
VL  - 819
SP  - 37
EP  - 43
SN  - 0077-8923
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19971407938.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 48 ref. Subject Subsets: Human Nutrition
N2  - The short-term and long-term effects of fat intake on energy balance are reviewed. The role of genetics in the variability of the metabolic response to fat intake is considered. It is concluded that a possible explanation for the epidemic of obesity in response to high-fat intake can be found in the oxidative hierarchy that regulates macronutrient balance in the human body. Fat intake does not promote fat oxidation and excess fat intake results in fat deposition and a new equilibrium is reached.
KW  - adipose tissue
KW  - body fat
KW  - energy balance
KW  - fats
KW  - genetics
KW  - intake
KW  - lipid metabolism
KW  - metabolism
KW  - obesity
KW  - reviews
KW  - weight gain
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fat metabolism
KW  - fatness
KW  - nutritional implications of macronutrient substitutes
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Replenishment of selenium deficient rats with selenium results in redistribution of the selenocysteine tRNA population in a tissue specific manner.
AU  - Chittum, H. S.
AU  - Hill, K. E.
AU  - Carlson, B. A.
AU  - Lee ByeongJae
AU  - Burk, R. F.
AU  - Hatfield, D. L.
JO  - Biochimica et Biophysica Acta, Molecular Cell Research
JF  - Biochimica et Biophysica Acta, Molecular Cell Research
Y1  - 1997///
VL  - 1359
IS  - 1
SP  - 25
EP  - 34
SN  - 0167-4889
AD  - Chittum, H. S.: Section on Molecular Biology of Selenium, Laboratory of Basic Research, Division of Basic Sciences, Building 37 Room 2D09, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991411793.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 52-90-4, 7782-49-2, 9014-25-9.  Subject Subsets: Human Nutrition
N2  - It was previously reported that the Se status of rats influenced both the steady-state levels and distributions of 2 selenocysteine (Sec) tRNA isoacceptors and that these isoacceptors differed by a single methyl group attached to the ribosyl moiety at position 34. In this study, it is demonstrated that repletion of Se-deficient rats results in a gradual, tissue-dependent shift in the distribution of these isoacceptors. Rats fed a Se-deficient diet possess a greater abundance of the species unmethylated on the ribosyl moiety at position 34 compared to the form methylated at this position. A redistribution of the Sec-tRNA isoacceptors occurred in tissues of Se-supplemented rats whereby the unmethylated form gradually shifted toward the methylated form. This was true in each of 4 tissues examined, muscle, kidney, liver and heart, although the rate of redistribution was tissue-specific. Muscle manifested a predominance of 2 minor serine isoacceptors under conditions of extreme Se-deficiency which also appeared to respond to Se. Ribosomal binding studies revealed that 1 of the 2 additional isoacceptors decodes the serine codeword, AGU, and the second decodes the serine codeword, UCU. Interestingly, muscle and heart were the slower tissues to return to a 'Se adequate' tRNA distribution pattern.
KW  - cysteine
KW  - deficiency
KW  - diet
KW  - heart
KW  - kidneys
KW  - liver
KW  - protein synthesis
KW  - ribosomes
KW  - selenium
KW  - skeletal muscle
KW  - tissues
KW  - transfer RNA
KW  - translation
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - protein biosynthesis
KW  - RNA translation
KW  - tRNA
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411793&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 infection in a man homozygous for CCR5Δ32.
AU  - O'Brien, T.
AU  - Winkler, C.
AU  - Dean, M.
AU  - Nelson, J. A. E.
AU  - Carrington, M.
AU  - Michael, N. L.
AU  - White, G. C.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1997///
IS  - 9060
SP  - 1219
EP  - 1219
SN  - 0140-6736
AD  - O'Brien, T.: Viral Epidemiology Branch and Laboratory of Genomic Diversity, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Bethesda, MD 20852, USA.
N1  - Accession Number: 19972010434.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Registry Number: 113189-02-9, 30516-87-1. 
N2  - A patient is described who was homozygous for CCR5Δ32, but nonetheless became infected with HIV-1. A white man, born in 1969 with severe haemophilia A, received over 500 000 units of Factor VIII concentrate from 1978 through 1984. He was positive for antibodies to HIV-1 at initial testing in 1985. He also had chronic hepatitis B virus antigenaemia and hepatitis C viraemia. His CD4 lymphocyte count was low (522/µl) in 1983 and fell to 158/µl by 1986. His count continued to fall (despite treatment with zidovudine beginning in 1989), but he had no HIV-1-associated conditions until oral hairy leukoplakia was diagnosed in 1983. He developed AIDS (oesophageal candidiasis) in 1985 and died of liver failure in 1996.
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - antigenaemia
KW  - CD4 antigens
KW  - chronic course
KW  - concentrates
KW  - factor VIII
KW  - haemophilia
KW  - hepatitis
KW  - hepatitis B
KW  - hepatitis C
KW  - infection
KW  - liver
KW  - lymphocytes
KW  - oral hairy leukoplakia
KW  - treatment
KW  - zidovudine
KW  - hepatitis B virus
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - AIDS
KW  - antigenemia
KW  - AZT
KW  - CD4
KW  - hemophilia
KW  - human immunodeficiency virus type 1
KW  - protein feeds
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010434&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of human caliciviruses in epidemic gastroenteritis.
AU  - Green, K. Y.
A2  - Kaaden, O. R.
A2  - Czerny, C. P.
A2  - Eichhorn, W.
JO  - Archives of Virology, Supplement
JF  - Archives of Virology, Supplement
Y1  - 1997///
IS  - Suppl. 13
SP  - 153
EP  - 165
SN  - 3211830146
AD  - Green, K. Y.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 129, Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982009347.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
N2  - The clinical features and transmission of epidemic gastroenteritis caused by Norwalk virus is discussed, as are research obstacles in the study of human caliciviruses, recent molecular biological approaches for the study of the human caliciviruses, and new epidemiological studies using recombinant protein-based assays.
KW  - clinical aspects
KW  - disease transmission
KW  - epidemics
KW  - epidemiology
KW  - foodborne diseases
KW  - gastroenteritis
KW  - gastrointestinal diseases
KW  - human diseases
KW  - identification
KW  - phylogenetics
KW  - reviews
KW  - viral diseases
KW  - waterborne diseases
KW  - Caliciviridae
KW  - man
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009347&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Human parvovirus B19 infections in infants and children.
AU  - Brown, K. E.
AU  - Young, N. S.
A2  - Aronoff, S. C.
T2  - Advances in pediatric infectious diseases: Volume 13.
JO  - Advances in pediatric infectious diseases: Volume 13.
JF  - Advances in pediatric infectious diseases: Volume 13.
Y1  - 1997///
SP  - 101
EP  - 126
CY  - St Louis, MO; USA
PB  - Mosby-Year Book, Inc.
SN  - 0815109601
AD  - Brown, K. E.: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982012800.  Publication Type: Miscellaneous.  Language: English.  Number of References: 119 ref.
KW  - children
KW  - clinical aspects
KW  - control
KW  - diagnosis
KW  - disease prevention
KW  - disease transmission
KW  - epidemiology
KW  - human diseases
KW  - immune response
KW  - infants
KW  - meningitis
KW  - pathogenesis
KW  - reviews
KW  - viral diseases
KW  - man
KW  - Parvovirus B19
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Parvovirus
KW  - Parvoviridae
KW  - ssDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - clinical picture
KW  - immunity reactions
KW  - immunological reactions
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012800&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Anti-HIV nucleosides: past, present and future.
AU  - Johns, D. G.\Welles, L.\Yarchoan, R.\Gu Zhengxian\Wainberg, M. A.\Shafer, R. W.\Merigan, T. C.
A2  - Mitsuya, H.
T2  - Anti-HIV nucleosides: past, present and future.
Y1  - 1997///
CY  - Georgetown; USA
PB  - R. G. Landes Company
SN  - 354061950X
AD  - Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19972005641.  Publication Type: Book.  Language: English. 
N2  - This book is divided into 5 chapters. The first, discusses the antiretroviral activity of nucleoside analogues; chapter 2 describes their pharmacology; chapter 3 focuses on therapy of HIV-1 infection with antiretroviral nucleosides; drug resistance is covered by chapter 4; and chapter 5 discusses combination therapy with nucleoside analogue reverse transcriptase inhibitors.
KW  - analogues
KW  - antiviral agents
KW  - drug resistance
KW  - drug therapy
KW  - enzyme inhibitors
KW  - HIV-1 infections
KW  - human diseases
KW  - metabolism
KW  - nucleoside analogues
KW  - nucleosides
KW  - pharmacology
KW  - reverse transcriptase inhibitors
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - chemotherapy
KW  - human immunodeficiency virus type 1
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005641&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Current approaches to diagnosis and treatment of candidiasis in children.
AU  - Walsh, T. J.
A2  - Aly, R.
A2  - Beutner, K. R.
A2  - Maibach, H.
T2  - Cutaneous infection and therapy.
Y1  - 1997///
CY  - New York; USA
PB  - Marcel Dekker Inc.
SN  - 0824798260
AD  - Walsh, T. J.: Pediatric Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981201334.  Publication Type: Book chapter.  Language: English.  Number of References: 114 ref.
KW  - antifungal agents
KW  - blood
KW  - candidosis
KW  - children
KW  - clinical aspects
KW  - diagnosis
KW  - drug therapy
KW  - human diseases
KW  - infants
KW  - infections
KW  - reviews
KW  - Candida
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - candidiasis
KW  - chemotherapy
KW  - clinical picture
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201334&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The role of peroxisome proliferator activated receptor α in peroxisome proliferation, physiological homeostasis, and chemical carcinogenesis.
AU  - Gonzalez, F. J.
T2  - Dietary fat and cancer: genetic and molecular interactions.
Y1  - 1997///
CY  - New York; USA
PB  - Plenum Publishing Corporation
SN  - 0306456834
AD  - Gonzalez, F. J.: Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19981412924.  Publication Type: Conference paper; Book chapter.  Language: English.  Number of References: 110 ref. Subject Subsets: Human Nutrition
N2  - The role of peroxisome proliferator-activated receptor α in carcinogenesis is reviewed under the headings: peroxisomes and peroxisome proliferation; The peroxisome proliferator-activated receptor (PPAR); Function of PPARs; Mechanism of gene activation by PPARα; Peroxisome proliferator-induced hepatocarcinogenesis; species differences and human risk assessment; The PPARα-null mouse; Isolation and characterization of the PPARα cDNA; Production of the PPARα-null mouse; Lipid metabolism in the PPARα-null mouse; The role of PPARα in dehydroepiandrosterone induction of peroxisome proliferation; PPARα and growth control; PPARα and peroxisome proliferation; PPARα and the mechanism of action of non-genotoxic carcinogens; and PPARα and species differences in response to peroxisome proliferators.
KW  - animal models
KW  - carcinogens
KW  - genotoxicity
KW  - lipid metabolism
KW  - neoplasms
KW  - peroxisomes
KW  - receptors
KW  - reviews
KW  - species differences
KW  - USA
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - fat metabolism
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412924&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Infectious diseases in immunocompromised hosts.
AU  - Georgiev, V. S.
T2  - Infectious diseases in immunocompromised hosts.
Y1  - 1997///
CY  - Boca Raton; USA
PB  - CRC Press Inc.
SN  - 0849385539
AD  - Georgiev, V. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982006246.  Publication Type: Book.  Language: English.  Subject Subsets: Public Health; Tropical Diseases; Protozoology; Helminthology
N2  - The sections covered and discussed in this book are: viral infections (Herpesviridae, Papovaviridae, Adenoviridae, Parvoviridae, Paramyxoviridae, Poxviridae and Hepadnaviridae) ; bacterial infections (Actinomycetes, Enterobacteriaceae, Campylobacter spp., non-cholera Vibrio spp., Listeria monocytogenes, gastrointestinal infections in the immunocompromised host, Neisseriaceae, Pseudomonadaceae, Rickettsiaceae, Alcaligenaceae, Leuconostoc spp., Treponema pallidum and Mycoplasma spp.); parasitic infections (Eucoccidiorida, Microsporidia, Leishmania spp., Strongyloides stercoralis, Cyclospora spp. and arthropod infestations in HIV-infected patients); and fungal infections (fungal cell envelope and mode of action of antimycotic agents, Deuteromycota (fungi imperfecti), Cryptococcus neoformans, Candida spp., Malassezia (Pityrosporum) spp., Trichosporon beigelii, Rhodotorula spp., other yeast-like fungi, fungi of the order Moniliales, Zygomycota, and Pneumocystis carinii).
KW  - bacterial diseases
KW  - helminths
KW  - HIV infections
KW  - human diseases
KW  - immunocompromised hosts
KW  - infectious diseases
KW  - microsporidiosis
KW  - mycoses
KW  - opportunistic infections
KW  - parasites
KW  - protozoal infections
KW  - viral diseases
KW  - yeasts
KW  - Actinomycetales
KW  - Adenoviridae
KW  - Alcaligenes
KW  - arthropods
KW  - Campylobacter
KW  - Candida
KW  - Cryptococcus neoformans
KW  - Cyclospora
KW  - Deuteromycotina
KW  - Enterobacteriaceae
KW  - Hepadnaviridae
KW  - Herpesviridae
KW  - Leishmania
KW  - Leuconostoc
KW  - Listeria monocytogenes
KW  - Malassezia
KW  - man
KW  - Microspora
KW  - Mycoplasma
KW  - Neisseriaceae
KW  - Paramyxoviridae
KW  - Parvoviridae
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Poxviridae
KW  - Protozoa
KW  - Pseudomonadaceae
KW  - Rhabditida
KW  - Rhodotorula
KW  - Rickettsiaceae
KW  - Strongyloides stercoralis
KW  - Treponema pallidum
KW  - Trichosporon beigelii
KW  - Vibrio
KW  - Zygomycota
KW  - fungi
KW  - eukaryotes
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Alcaligenaceae
KW  - Burkholderiales
KW  - Betaproteobacteria
KW  - Proteobacteria
KW  - invertebrates
KW  - animals
KW  - Campylobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Eimeriidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - DNA Reverse Transcribing Viruses
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Leuconostocaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Listeria
KW  - Listeriaceae
KW  - Bacillales
KW  - Malasseziales
KW  - Ustilaginomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Mycoplasmataceae
KW  - Mycoplasmatales
KW  - Mollicutes
KW  - Neisseriales
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - ssDNA viruses
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Pseudomonadales
KW  - Sporidiobolales
KW  - Microbotryomycetes
KW  - Pucciniomycotina
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Strongyloides
KW  - Strongyloididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - Treponema
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Zygomycota
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - communicable diseases
KW  - fungus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - nematodes
KW  - Papovaviridae
KW  - parasitic worms
KW  - protozoal diseases
KW  - Secernentea
KW  - viral infections
KW  - Zygomycotina
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006246&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Nutritional abnormalities in infectious diseases: effects on tuberculosis and AIDS.
A2  - Taylor, C. E.
T2  - Nutritional abnormalities in infectious diseases: effects on tuberculosis and AIDS.
Y1  - 1997///
CY  - New York; USA
PB  - Haworth Press Inc.
SN  - 0789000199
AD  - Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.
N1  - Accession Number: 19981405160.  Publication Type: Book.  Language: English.  Number of References: many ref. Subject Subsets: Human Nutrition
N2  - The book is divided into eight chapters entitled: nutritional determinants of resistance to tuberculosis; effects of protein calorie malnutrition on mice infected with BCG; vitamin A nutritional status - relationship to the infection and the antibody response; modulation of phagocyte function by nutrition in human immunodeficiency virus (HIV)-1 infection; malnutrition as a co-factor in HIV disease; clinical aspects of nutrition in tuberculosis; malnutrition and acquired immune deficiency syndrome (AIDS) in the developing world; and tuberculosis and the nutritionally disadvantaged - conclusions.
KW  - acquired immune deficiency syndrome
KW  - human immunodeficiency viruses
KW  - immunity
KW  - infectious diseases
KW  - malnutrition
KW  - nutritional disorders
KW  - tuberculosis
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - communicable diseases
KW  - human immunodeficiency virus
KW  - Nutritional abnormalities in infectious diseases: effects on tuberculosis and AIDS
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981405160&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Care and maintenance of phlebotomine sandfly colonies.
AU  - Modi, G. B.
A2  - Crampton, J. M.
A2  - Beard, C. B.
A2  - Louis, C.
T2  - The molecular biology of insect disease vectors: a methods manual.
Y1  - 1997///
CY  - London; UK
PB  - Chapman & Hall Ltd
SN  - 0412736608
AD  - Modi, G. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980504330.  Publication Type: Book chapter.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - laboratory rearing
KW  - maintenance
KW  - rearing techniques
KW  - Diptera
KW  - Lutzomyia
KW  - Phlebotominae
KW  - Phlebotomus
KW  - Psychodidae
KW  - Sergentomyia
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Other Invertebrate Culture (Not Aquaculture) (LL030) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504330&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin.
AU  - Chuang, R. S. I.
AU  - Jaffe, H.
AU  - Cribbs, L.
AU  - Perez-Reyes, E.
AU  - Swartz, K. J.
JO  - Nature Neuroscience
JF  - Nature Neuroscience
Y1  - 1998///
VL  - 1
IS  - 8
SP  - 668
EP  - 674
AD  - Chuang, R. S. I.: Molecular Physiology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 36, Rm. 2C19, 36 Convent Drive, MSC 4066, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990504761.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The biophysical properties of T-type voltage-gated calcium channels are well suited to pacemaking and to supporting calcium flux near the resting membrane potential in both excitable and non-excitable cells. A new scorpion toxin (kurtoxin) from Parabuthus transvaalicus that binds to the α1G T-type calcium channel with high affinity and inhibits the channel by modifying voltage-dependent gating was identified. This toxin distinguishes between α1G T-type calcium channels and other types of voltage-gated calcium channels, including α1A, α1B, α1C, and α1E. Like the other α-scorpion toxins to which it is related, kurtoxin also interacts with voltage-gated sodium channels and slows their inactivation. It is hypothesised that kurtoxin will facilitate characterization of the subunit composition of T-type calcium channels and help determine their involvement in electrical and biochemical signalling.
KW  - calcium channels
KW  - ion channels
KW  - ion transport
KW  - mode of action
KW  - toxins
KW  - Arachnida
KW  - Buthidae
KW  - Scorpiones
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Scorpiones
KW  - Arachnida
KW  - Buthidae
KW  - kurtoxin
KW  - Parabuthus
KW  - Parabuthus transvaalicus
KW  - toxinology
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504761&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduction in SIV replication in rhesus macaques infused with autologous lymphocytes engineered with antiviral genes.
AU  - Donahue, R. E.
AU  - Bunnell, B. A.
AU  - Zink, M. C.
AU  - Metzger, M. E.
AU  - Westro, R. P.
AU  - Kirby, M. R.
AU  - Unangst, T.
AU  - Clements, J. E.
AU  - Morgan, R. A.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1998///
VL  - 4
IS  - 2
SP  - 181
EP  - 186
AD  - Donahue, R. E.: Clinical Gene Therapy Branch, National Human Genome Research Institute, NIH, B.dg 10, Rm 10C103, 10 Center Drive, Bethesda, MD 20892-1851, USA.
N1  - Accession Number: 19982004291.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - To test a potential anti-HIV gene therapy strategy in the SIV animal model of HIV infection, CD4+ cell-enriched lymphocytes from 3 rhesus macaques were subjected to retrovirally mediated gene transfer with a vector expressing an antisense tat/rev gene. This group of animals and 3 control macaques were subsequently infected with SIVmac239. Blood and lymph nodes from all macaques were sampled for more than a year to monitor the progress of infection. Although all animals became infected, the animals that received the lymphocytes engineered with the antisense vector demonstrated a significant reduction in viral load in both peripheral blood and lymph nodes, had sustained numbers of CD4+ cells, and exhibited little disruption of lymph-node architecture.
KW  - animal models
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - disease vectors
KW  - gene transfer
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - lymph nodes
KW  - lymphocytes
KW  - replication
KW  - vectors
KW  - viral load
KW  - Macaca
KW  - Macaca mulatta
KW  - man
KW  - simian immunodeficiency virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Macaca
KW  - Homo
KW  - Hominidae
KW  - CD4+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T4 lymphocytes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004291&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency.
AU  - Glushakova, S.
AU  - Grivel, J. C.
AU  - Fitzgerald, W.
AU  - Sylwester, A.
AU  - Zimmerberg, J.
AU  - Margolis, L. B.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1998///
VL  - 4
IS  - 3
SP  - 346
EP  - 349
AD  - Glushakova, S.: Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development NIH, Bldg 10, Rm 10D14, 10 Center Drive, Bethesda, MD 20892-1855, USA.
N1  - Accession Number: 19982004437.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear. Initial infection with HIV-1 is transmitted by macrophage (M)-tropic/non-syncytia-inducing (NSI) viruses, which hyperactivate the immune system, and, in one view, cause immunodeficiency by "exhaustion" of lymphoid tissue. An alternative hypothesis is that immunodeficiency is caused by the replacement of M-tropic viruses by T-cell (T)-tropic/syncytia-inducing (SI) viruses, which are known to be highly cytopathic in vitro and emerge late in infected individuals around the time of transition to AIDS. To test these 2 possibilities, an ex vivo model of humoral immunity to recall antigens was developed using human lymphoid tissue. This tissue supports productive infection with both M- and T-tropic HIV-1 isolates when cultured ex vivo. It was found that specific immune responses were enhanced by productive infection of the tissue with M-tropic/NSI HIV-1 isolates, but were blocked by T-tropic/SI HIV-1 isolates. The mechanism involves specific irreversible effect on B-cell activity. These results support the hypothesis that the phenotype switch to T-tropic viruses is a key determinant of acquired humoral immunodeficiency in patients infected with HIV.
KW  - acquired immune deficiency syndrome
KW  - antigens
KW  - B lymphocytes
KW  - effects
KW  - human diseases
KW  - humoral immunity
KW  - immune response
KW  - immunity
KW  - immunopathology
KW  - in vitro
KW  - infection
KW  - macrophages
KW  - pathogenesis
KW  - patients
KW  - phenotypes
KW  - syncytia
KW  - T lymphocytes
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - antigenicity
KW  - B cells
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - immunopathogenesis
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004437&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - New and reemerging diseases: the importance of biomedical research.
AU  - Fauci, A. S.
JO  - Emerging Infectious Diseases
JF  - Emerging Infectious Diseases
Y1  - 1998///
VL  - 4
IS  - 3
SP  - 374
EP  - 378
AD  - Fauci, A. S.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990502303.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref.
KW  - emerging infectious diseases
KW  - human diseases
KW  - infectious diseases
KW  - research
KW  - communicable diseases
KW  - emerging diseases
KW  - emerging infections
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502303&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Synergistic effects of 8-Chlorocyclic-AMP and retinoic acid on induction of apoptosis in ewing's sarcoma CHP-100 cells.
AU  - Srivastava, R. K.
AU  - Srivastava, A. R.
AU  - Yoon, S. C. C.
JO  - Clinical Cancer Research
JF  - Clinical Cancer Research
Y1  - 1998///
VL  - 4
IS  - 3
SP  - 755
EP  - 761
AD  - Srivastava, R. K.: Cellular Biochemistry Section, Laboratory of Tumor Immunology, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19981408801.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - The enhanced expression of the regulatory subunit of cyclic AMP (cAMP)-dependent protein kinase type I, RIα, has been correlated with cancer cell growth. Retinoic acid (RA) has been shown to play an important role in the regulation of proliferation and differentiation in neoplastic cells. This study examined the effects of cAMP analogue 8-chlorocyclic-AMP (8-CI-cAMP) and RA (both singly and combined) on growth inhibition and apoptosis in Ewing's sarcoma CHP-100 cells were evaluated. The inhibitory effects of 8-CI-cAMP and RA (9-cis-RA, 13-cis-RA and all-trans-RA) on cell viability were time and dose related. The degree of growth inhibition induced by 9-cis-RA was the greatest among all of the RA analogues (13-cis-RA and all-trans-RA) examined. The combined effects of 8-Cl-cAMP and RA on the induction of growth arrest at the G0-G1 stage of the cell cycle, apoptosis, down-regulation of RIα and cleavage of poly(ADP-ribose) polymerase were synergistic. It was concluded that RA and 8-Cl-cAMP act in a synergistic fashion and have potential for combination chemotherapy for the treatment of malignant disease.
KW  - antineoplastic agents
KW  - drug therapy
KW  - neoplasms
KW  - retinoic acid
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - chemotherapy
KW  - cytotoxic agents
KW  - tretinoin
KW  - vitamin A acid
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408801&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Genetic effects on HIV disease progression.
AU  - Ionnidis, J. P. A.
AU  - O'Brien, T. R.
AU  - Rosenberg, P. S.
AU  - Contopoulos-Ioannidis, D. G.
AU  - Goedert, J. J.
T2  - Nature Medicine
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1998///
VL  - 4
IS  - 5
SP  - 536
EP  - 536
AD  - Ionnidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA.
N1  - Accession Number: 19982007269.  Publication Type: Correspondence.  Language: English.  Number of References: 6 ref.
N2  - The controversy surrounding the effect of specific chemokine receptor polymorphisms on HIV disease progression highlights the need for synthesis of the pertinent evidence. It also suggests that large-scale international collaborations are indispensable when it comes to addressing important questions in the field. An international meta-analysis of HIV host genetics is proposed. The meta-analysis is sponsored by the HIV/AIDS Collaborative Review Group of the International Cochrane Collaboration. The Collaboration's principles of being systematic, all-inclusive and objective benefit this rapidly growing field. For further details contact: ji24m@NIH.gov.
KW  - acquired immune deficiency syndrome
KW  - chemokines
KW  - cytokines
KW  - disease course
KW  - genetic variation
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - receptors
KW  - resistance
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - disease progression
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007269&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemokines and HIV-2 second receptors: the therapeutic connection.
AU  - Cairns, J. S.
AU  - D'Souza, M. P.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1998///
VL  - 4
IS  - 5
SP  - 563
EP  - 568
AD  - Cairns, J. S.: Pathogenesis and Basic Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Bldg. 2C35, Bethesda, MD 20892,USA.
N1  - Accession Number: 19982007270.  Publication Type: Journal Article.  Language: English.  Number of References: 76 ref.
KW  - chemokines
KW  - cytokines
KW  - pathogenesis
KW  - receptors
KW  - uptake
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007270&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein.
AU  - Bera, T. K.
AU  - Kennedy, P. E.
AU  - Berger, E. A.
AU  - Barbas, C. F. III
AU  - Pastan, I.
JO  - Molecular Medicine
JF  - Molecular Medicine
Y1  - 1998///
VL  - 4
IS  - 6
SP  - 384
EP  - 391
AD  - Bera, T. K.: Laboratory of Molecular Biology, National Cancer Institute, NIH, Bldg 37, Rm 4E16, 37 Convent Drive, MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19982010891.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9007-49-2. 
N2  - Recombinant DNA technology was used to clone the Fv fragment of 3B3 (a high-affinity anti-gp120 antibody) and produce a single chain Fv (scFv). 3B3 scFv was then fused to a truncated version of Pseudomonas exotoxin A (PE38), giving rise to a recombinant immunotoxin 3B3(Fv)-PE38 that was expressed in E. coli and purified to near homogeneity. 3B3 (Fv)-PE38 binds with the same affinity as the parental Fab antibody to the MN strain of gp120. The immunotoxin specifically kills a gp120-expressing transfected cell line and a chronically HIV-infected lymphocytic cell line. The immunotoxin is very stable at 37°C, retaining 80% of its original activity after 24 hr.
KW  - antibodies
KW  - antiviral agents
KW  - cell lines
KW  - clones
KW  - DNA
KW  - envelope glycoproteins
KW  - envelope protein gp120
KW  - exotoxins
KW  - glycoproteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunotherapy
KW  - lymphocytes
KW  - recombinant DNA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Pseudomonas
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pseudomonadaceae
KW  - Pseudomonadales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - exotoxin A
KW  - gp120
KW  - homogeneity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010891&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Peripheral expansion of preexisting mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults.
AU  - Walker, R. E.
AU  - Carter, C. S.
AU  - Muul, L.
AU  - Natarajan, V.
AU  - Herpin, B. R.
AU  - Leitman, S. F.
AU  - Klein, H. G.
AU  - Mullen, C. A.
AU  - Metcalf, J. A.
AU  - Baseler, M.
AU  - Falloon, J.
AU  - Davey, R. T. Jr.
AU  - Kovacs, J. A.
AU  - Polis, M. A.
AU  - Masur, H.
AU  - Blaese, R. M.
AU  - Lane, H. C.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1998///
VL  - 4
IS  - 7
SP  - 852
EP  - 856
AD  - Walker, R. E.: Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 11S231, NIH Bethesda, MD 20892, USA.
N1  - Accession Number: 19982012104.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - The CD4+ T-cell pool in HIV-infected patients is in a constant state of flux as CD4+ T cells are infected and destroyed by HIV and new cells take their place. To study T-cell survival, peripheral blood lymphocytes transduced with the neomycin phosphotransferase gene were adoptively transduced between syngeneic twin pairs discordant for HIV infection. A stable fraction of marked CD4+ T cells persisted in the circulation of 4 to 18 weeks after transfer in all patients. After this time there was a precipitous decline in marked cells in 3 of the patients. At ~6 months, marked cells were in lymphoid tissues in proportions comparable to those found in peripheral blood. In two patients, the proportion of total signal for the transgene (found by PCR analysis) in the CD4/CD45RA+ T-cell population relative to the CD4/CD45RO+ population increased in the weeks after cell infusion. These findings indicate that genetically-marked CD4+ T cells persist in vivo for weeks to months and that the CD4+ T-cell pool in adults is maintained mostly by the division of mature T cells rather than by differentiation of prethymic stem cells. Thus, after elements of the T-cell repertoire are lost through HIV infection, they may be difficult to replace.
KW  - CD4+ lymphocytes
KW  - differentiation
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - lymphocyte transformation
KW  - survival
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012104&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection.
AU  - Sanjay Gurunathan
AU  - Prussin, C.
AU  - Sacks, D. L.
AU  - Seder, R. A.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1998///
VL  - 4
IS  - 12
SP  - 1409
EP  - 1415
AD  - Sanjay Gurunathan: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990805747.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Protozoology
N2  - Mice vaccinated either with Leishmania major protein and recombinant interleukin-12 (rIL-12), or with plasmid DNA encoding the protein, controlled footpad swelling when infected 2 weeks later with L. major, but when the challenge was given after 12 weeks, only those vaccinated with the DNA controlled the infection. rIL-12 in combination with other antigens was no more effective than with this protein. Experiments using a different protein showed that leishmanial protein plus IL-12 DNA produced an immunity that lasted much longer than that elicited by leishmanial protein plus IL-12 protein. Lymph nodes from mice which were still capable of controlling infection produced interferon-γ, but those from mice which were no longer immune did not. Treatment with anti-IL-12 antibody abrogated immunity. It is concluded that the persistence of IL-12 may be the essential determinant in maintaining durable cell-mediated immune responses against intracellular parasitic infection.
KW  - animal diseases
KW  - antigens
KW  - cell mediated immunity
KW  - DNA vaccines
KW  - experimental infections
KW  - human diseases
KW  - immune response
KW  - immunity
KW  - immunization
KW  - interleukin 12
KW  - interleukins
KW  - intracellular parasitism
KW  - laboratory animals
KW  - leishmaniasis
KW  - parasites
KW  - plasmid vectors
KW  - recombinant proteins
KW  - recombinant vaccines
KW  - vaccination
KW  - vaccines
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - antigenicity
KW  - cellular immunity
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - leishmaniosis
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805747&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-dendritic cell interactions promote efficient viral infection of T cells.
AU  - Zoeteweij, J. P.
AU  - Blauvelt, A.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1998///
VL  - 5
IS  - 4
SP  - 253
EP  - 259
AD  - Zoeteweij, J. P.: Dermatology Branch, National Cancer Institute, Bldg 10, Rm 12N238, 10 Center Dr., MSC 1908, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19982011108.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
N2  - HIV-dendritic cell (DC) interactions may promote efficient viral infection of T cells in a variety of settings and disease stages. Future studies will likely focus on the role of DCs in animal and organ culture models of primary HIV infection. Additionally, blocking HIV-DC interactions during both acute and chronic HIV disease may become an important therapeutic strategy for blocking infection and depletion of T cells.
KW  - chemokines
KW  - chronic course
KW  - cytokines
KW  - dendritic cells
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - pathogenesis
KW  - receptors
KW  - reviews
KW  - T lymphocytes
KW  - viral diseases
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Langerhans cells
KW  - T cells
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011108&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - And the best picture is-the HIV gp120 envelope, please!
AU  - Berger, E. A.
JO  - Nature Structural Biology
JF  - Nature Structural Biology
Y1  - 1998///
VL  - 5
IS  - 8
SP  - 671
EP  - 674
SN  - 1072-8368
AD  - Berger, E. A.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bldg 4, Rm 236, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982012099.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref.
N2  - Investigation of the X-ray crystallographic structure of the gp120 core coupled with mutagenesis analyses reveal details of receptor interactions and multiple layers of immune evasion.
KW  - chemokines
KW  - cytokines
KW  - envelope protein gp120
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - receptors
KW  - structure
KW  - X ray crystallography
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - gp120
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012099&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fatty acid metabolism in mitochondria: Defects and genetics.
AU  - Coates, P. M.
JO  - BioFactors
JF  - BioFactors
Y1  - 1998///
VL  - 7
IS  - 3
SP  - 201
EP  - 202
AD  - Coates, P. M.: Division of Nutrition Research Coordination, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981408077.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Human Nutrition
KW  - defects
KW  - fatty acids
KW  - genetic disorders
KW  - ketogenesis
KW  - lipid metabolism
KW  - metabolism
KW  - mitochondria
KW  - oxidation
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - fat metabolism
KW  - genetic defects
KW  - hereditary defects
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408077&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Impact of ofloxacin used prophylactically in neutropenic patients on development of resistance.
AU  - Spanik, S.
AU  - Studena, M.
AU  - Sykora, J.
AU  - Kunova, A.
AU  - Trupl, J.
AU  - Pichna, P.
AU  - Demitrovicova, A.
AU  - Kralovicova, K.
AU  - Grey, E.
AU  - Kukuckova, E.
AU  - Koren, P.
AU  - Krcmery, V., Jr.
JO  - Infectious Diseases in Clinical Practice
JF  - Infectious Diseases in Clinical Practice
Y1  - 1998///
VL  - 7
IS  - 4
SP  - 199
EP  - 202
SN  - 1056-9103
AD  - Spanik, S.: Department of Medicine, Pharmacology, and Microbiology, National Cancer Institute, Bratislava, Slovakia.
N1  - Accession Number: 19992005900.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 82419-36-1. 
N2  - The association between use of ofloxacin as prophylaxis for febrile neutropenia and incidence of Gram-negative bacteraemia and resistance development in Enterobacteriaceae and Pseudomonas aeruginosa was studied in a national referral cancer centre in Bratislava, Slovakia. Despite increasing use of ofloxacin, from 0 g/year in 1990 to 2350 g/year in 1996, no increase in resistance in Enterobacteriaceae was observed. The overall incidence of resistance to quinolones was 2.8%. Only 2 ofloxacin-resistant Escherichia coli strains were observed within 8 years. However, the incidence of resistance by P. aeruginosa against ofloxacin during the observation period was 6.4%-21.0%. It is concluded that increasing use of ofloxacin did not cause significant changes in resistance within the previous 8 years in Gram-negative bacilli, with the exception of Acinetobacter spp.
KW  - bacteraemia
KW  - drug resistance
KW  - Gram negative bacteria
KW  - human diseases
KW  - immunocompromised hosts
KW  - neoplasms
KW  - neutropenia
KW  - ofloxacin
KW  - opportunistic infections
KW  - prophylaxis
KW  - quinolones
KW  - Slovakia
KW  - Acinetobacter
KW  - Bacteria
KW  - Enterobacteriaceae
KW  - Escherichia coli
KW  - man
KW  - Pseudomonas aeruginosa
KW  - Bacteria
KW  - prokaryotes
KW  - Moraxellaceae
KW  - Pseudomonadales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Enterobacteriales
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pseudomonas
KW  - Pseudomonadaceae
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - bacteremia
KW  - bacterium
KW  - cancers
KW  - E. coli
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005900&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A survey of human papillomavirus 16 antibodies in patients with epithelial cancers.
AU  - Strickler, H. D.
AU  - Schiffman, M. H.
AU  - Shah, K. V.
AU  - Rabkin, C. S.
AU  - Schiller, J. T.
AU  - Wacholder, S.
AU  - Clayman, B.
AU  - Viscidi, R. P.
JO  - European Journal of Cancer Prevention
JF  - European Journal of Cancer Prevention
Y1  - 1998///
VL  - 7
IS  - 4
SP  - 305
EP  - 313
SN  - 0959-8278
AD  - Strickler, H. D.: National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, Room 434, Rockville, MD 20852, USA.
N1  - Accession Number: 19982013262.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Registry Number: 308067-58-5.  Subject Subsets: Public Health
N2  - To assess exposure to human papillomavirus (HPV) 16 in patients with different cancers, a large serosurvey of 905 patients from Minnesota, USA, with 21 types of tumours was conducted, and IgG to HPV 16 virus-like particles were measured using a well characterized ELISA. The specimens tested were collected by a serum bank between 1975 and 1991. Patients with cervical cancer were considered 'positive controls', as about half were expected to be specifically HPV 16-related. A non-cancer study group consisting of 48 patients with endocrine disorders (e.g. diabetes) was also tested. HPV 16 antibody prevalence was highest in patients with cancers of the cervix (52±7%), vulva (27±9%), vagina (27±13%) and penis (63±16%). Seroprevalence was much lower in the non-cancer group (4±3%) and all other cancer patients: uterus (9±4%); ovary (4±3%); testis (5±4%); prostate (6±4%); squamous carcinoma (6±3%) and adenocarcinoma (4±3%) of the lung; rectum (2±2%); pancreas (8±4%); colon (2±2%); stomach (0%); oesophagus (8±4%); buccal cavity (12±5%); breast (10±4%); non-melanomatous (9±6%) and melanomatous (6±3%) skin tumours; bladder (8±4%); and kidney (2±2%). The results confirm the strong relation of HPV with several lower anogenital tract tumours, but, at least in this population, fail to identify additional epithelial tumours associated with high seroprevalence of HPV 16 VLP antibodies.
KW  - antibodies
KW  - carcinoma
KW  - epidemiology
KW  - epithelium
KW  - human diseases
KW  - IgG
KW  - neoplasms
KW  - seroprevalence
KW  - viral diseases
KW  - Minnesota
KW  - USA
KW  - human papillomavirus 16
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lake States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - Papillomaviridae
KW  - cancers
KW  - human papillomavirus
KW  - Papovaviridae
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013262&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The mosquito dihydrofolate reductase amplicon contains a truncated synaptic vesicle protein gene.
AU  - Wang, Z. H.
AU  - Fallon, A. M.
JO  - Insect Molecular Biology
JF  - Insect Molecular Biology
Y1  - 1998///
VL  - 7
IS  - 4
SP  - 317
EP  - 325
SN  - 0962-1075
AD  - Wang, Z. H.: National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980504862.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 9002-03-3, 59-05-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - When maintained under continuous selection with the folate inhibitor, methotrexate, cultured Aedes albopictus cells amplify an ~200 kb region of DNA containing the dihydrofolate reductase gene. To determine whether the amplicon contained additional coding regions, Southern blots of cosmid clones containing amplicon DNA were probed separately with reverse-transcribed mRNA from methotrexate-sensitive and methotrexate-resistant cells. Cosmid pWED118 contained 5 EcoRI fragments (A, B, C, F, G) ranging in size from 2 to 5 kb that hybridized with cDNA from resistant cells. Of these, fragments B and F also hybridized to probe representing mRNA from sensitive cells, and all but fragment G hybridized to repetitive DNA from wild-type cells. Fragment G, which appeared to encode a low copy number gene in wild-type cells that subsequently became part of the dihydrofolate reductase amplicon in methotrexate-resistant cells, hybridized strongly to a 7 kb band and more weakly to bands measuring 9 and 3 kb on Northern blots containing RNA from resistant cells. Fragment G contained a 1203 bp open reading frame, encoding 401 amino acids homologous to synaptic vesicle protein SV2, a member of a transmembrane transporter family expressed in neural and endocrine cells. The region of homology included the 6 N-terminal transmembrane domains, an internal cytoplasmic loop, a 7th transmembrane domain, and most of an intravesicular loop. This partial sequence, which appears to correspond to a truncated gene generated during formation of the dihydrofolate reductase amplicon, provides a useful basis for more extensive characterization of an important gene family that may be the target of novel insecticides.
KW  - amplification
KW  - cell lines
KW  - cells
KW  - dihydrofolate reductase
KW  - genes
KW  - genetics
KW  - inhibitors
KW  - methotrexate
KW  - molecular biology
KW  - molecular genetics
KW  - nucleotide sequences
KW  - open reading frames
KW  - proteins
KW  - resistance
KW  - vesicles
KW  - Aedes albopictus
KW  - Culicidae
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - amethopterin
KW  - amplicons
KW  - Asian tiger mosquito
KW  - biochemical genetics
KW  - DNA sequences
KW  - mosquitoes
KW  - ORFs
KW  - synapses
KW  - tetrahydrofolate dehydrogenase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Association between consumption of antibiotics and development of resistance: 8-year experience from a Slovakian cancer center.
AU  - Sykora, P.
AU  - Trupl, J.
T2  - Infectious Diseases in Clinical Practice
JO  - Infectious Diseases in Clinical Practice
JF  - Infectious Diseases in Clinical Practice
Y1  - 1998///
VL  - 7
IS  - 7
SP  - 364
EP  - 365
SN  - 1056-9103
AD  - Sykora, P.: Department of Clinical Pharmacology, Microbiology and Pharmacy, National Cancer Institute, St. Elizabeth's Cancer Institute, Bratislava, Slovakia.
N1  - Accession Number: 19992007312.  Publication Type: Correspondence.  Language: English.  Number of References: 3 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 1404-90-6, 1404-93-9. 
KW  - ampicillin
KW  - drug resistance
KW  - drug therapy
KW  - human diseases
KW  - neoplasms
KW  - penicillins
KW  - vancomycin
KW  - Slovakia
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - cancers
KW  - chemotherapy
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007312&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy.
AU  - Klebanoff, M. A.
AU  - Levine, R. J.
AU  - Dersimonian, R.
AU  - Clemens, J. D.
AU  - Wilkins, D. G.
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
Y1  - 1998///
VL  - 8
IS  - 2
SP  - 107
EP  - 111
SN  - 1047-2797
AD  - Klebanoff, M. A.: Division of Epidemiology, Statistics, and Preventive Research, National Institute of Child Health and Human Development, NIH, 6100 Bldg Room 7B03, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19981406036.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 58-08-2.  Subject Subsets: Human Nutrition
N2  - Serum concentrations of caffeine and paraxanthine were determined by HPLC in 60 women with normal pregnancy outcomes who reported consuming ≤ 0.8 mg/kg per day of caffeine in a 24-h dietary recall, 60 who consumed 0.81-2.5 mg/kg per day, 60 who consumed 2.51-5.00 mg/kg per day and 59 who consumed ≥ 5.01 mg/kg per day. The weighted kappa coefficient between strata of caffeine intake and quartiles of serum paraxanthine was 0.58 among smokers and 0.53 among non-smokers, vs. 0.44 and 0.51, respectively, for quartiles of serum caffeine. The Pearson correlation coefficient between intake and paraxanthine was 0.50 for smokers and 0.53 for non-smokers, and 0.37 and 0.51, respectively, for serum caffeine. These values are comparable to the correlation between reported smoking and serum cotinine in pregnancy. It is concluded that serum concentrations of paraxanthine, and to a lesser degree, caffeine are useful to distinguish between women with varying levels of caffeine intake.
KW  - analytical methods
KW  - caffeine
KW  - intake
KW  - markers
KW  - pregnancy
KW  - serum
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - gestation
KW  - paraxanthine
KW  - Techniques and Methodology (ZZ900) 
KW  - Diet Studies (VV110) 
KW  - Human Reproduction and Development (VV060) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Advances in the treatment of chronic hepatitis B virus infection.
AU  - Marques, A. R.
AU  - Straus, S. E.
JO  - Reviews in Medical Virology
JF  - Reviews in Medical Virology
Y1  - 1998///
VL  - 8
IS  - 4
SP  - 223
EP  - 234
SN  - 1052-9276
AD  - Marques, A. R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992004245.  Publication Type: Journal Article.  Language: English.  Number of References: 77 ref.
N2  - Recent advances in our understanding of the replicative mechanism of HBV, and the development of potent nucleoside analogues as clinically effective inhibitors of the HIV reverse transcriptase or herpesvirus polymerases has opened a new era in the treatment of chronic HBV infection. Single agent therapies, such as famciclovir, lamivudine or lobucavir, have had some success. There is now a logical basis for combination therapy, because of the clear need for prolonged treatment and the associated possibility that drug resistant strains will emerge with monotherapy, but the choice of agents to combine and the regimens in which they should be employed remain uncertain.
KW  - analogues
KW  - drug therapy
KW  - hepatitis B
KW  - human diseases
KW  - nucleoside analogues
KW  - nucleosides
KW  - reviews
KW  - hepatitis B virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - chemotherapy
KW  - nucleoside analogs
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis.
AU  - Hallock, Y. F.
AU  - Cardellina, J. H., II
AU  - Schäffer, M.
AU  - Bringmann, G.
AU  - François, G.
AU  - Boyd, M. R.
JO  - Bioorganic & Medicinal Chemistry Letters
JF  - Bioorganic & Medicinal Chemistry Letters
Y1  - 1998///
VL  - 8
IS  - 13
SP  - 1729
EP  - 1734
SN  - 0960-894X
AD  - Hallock, Y. F.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Building 1052, Room 121, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19990801959.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Protozoology
N2  - A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A, comprised of 2 different monomeric biaryl halves, was isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.
KW  - alkaloids
KW  - antimalarials
KW  - antiprotozoal agents
KW  - antiprotozoal properties
KW  - in vitro
KW  - medicinal plants
KW  - novel antiprotozoal agents
KW  - parasites
KW  - plant extracts
KW  - Cameroon
KW  - Ancistrocladaceae
KW  - Ancistrocladus
KW  - Ancistrocladus korupensis
KW  - Human immunodeficiency virus 1
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Ancistrocladaceae
KW  - Ancistrocladus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - anti-protozoal properties
KW  - drug plants
KW  - human immunodeficiency virus type 1
KW  - korundamine A
KW  - medicinal herbs
KW  - naphthylisoquinoline
KW  - naphthylisoquinoline alkaloid
KW  - officinal plants
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-food/Non-feed Plant Products (SS200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Absorption, transport, and disposition of ascorbic acid in humans.
AU  - Rumsey, S. C.
AU  - Levine, M.
JO  - Journal of Nutritional Biochemistry
JF  - Journal of Nutritional Biochemistry
Y1  - 1998///
VL  - 9
IS  - 3
SP  - 116
EP  - 130
SN  - 0955-2863
AD  - Rumsey, S. C.: Molecular and Clinical Nutrition Section, National Institutes of Health, Bethesda, MD 20892-1372, USA.
N1  - Accession Number: 19981408365.  Publication Type: Journal Article.  Language: English.  Number of References: 209 ref. Registry Number: 50-81-7, 490-83-5.  Subject Subsets: Human Nutrition
N2  - A review.
KW  - absorption
KW  - ascorbic acid
KW  - availability
KW  - dehydroascorbic acid
KW  - distribution
KW  - excretion
KW  - pharmacokinetics
KW  - tissues
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Targeting RNase L to human immunodeficiency virus RNA with 2-5A-antisense.
AU  - Player, M. R.
AU  - Maitra, R. K.
AU  - Silverman, R. H.
AU  - Torrence, P. F.
JO  - Antiviral Chemistry & Chemotherapy
JF  - Antiviral Chemistry & Chemotherapy
Y1  - 1998///
VL  - 9
IS  - 3
SP  - 225
EP  - 231
SN  - 0956-3202
AD  - Player, M. R.: Section on Biomedical Chemistry, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0805, USA.
N1  - Accession Number: 19982014890.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 63231-63-0. 
N2  - In an attempt to develop a lead for the application of 2-5A-antisense to the targeted destruction of human immunodeficiency virus (HIV) RNA, specific target sequences within the HIV mRNAs were identified by analysis of the theoretical secondary structure. 2-5A-antisense chimeras were chosen against a total of 11 different sequences: three in the gag mRNA, three in the rev mRNA and five in the tat mRNA. 2-5A-antisense chimera synthesis was accomplished using solid-phase phosphoramidite chemistry. These chimeras were evaluated for their activity in a cell-free assay system using purified recombinant human RNase L to effect cleavage of 32P-labelled RNA transcripts of plasmids derived from HIV NL4-3. This screening revealed that of the three 2-5A-antisense chimeras targeted against gag mRNA, only one had significant HIV RNA cleavage activity, approximately 10-fold-reduced compared to the parent 2-5A tetramer and comparable to that reported for the prototypical 2-5A-anti-PKR chimera, targeted against PKR mRNA. The cleavage activity of this chimera was specific, since a scrambled antisense domain chimera and a chimera without the key 5′-monophosphate moiety were both inactive. The 10 other 2-5A-antisense chimeras against tat and rev had significantly less activity. These results imply that HIV gag RNA, like PKR RNA and a model HIV tat-oligoA-vif RNA, can be cleaved using the 2-5A-antisense approach. The results further imply that not all regions of a potential RNA target are accessible to the 2-5A-antisense approach.
KW  - acquired immune deficiency syndrome
KW  - chimaeras
KW  - culture media
KW  - effects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - messenger RNA
KW  - plasmids
KW  - ribonucleases
KW  - RNA
KW  - structure
KW  - synthesis
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cell free media
KW  - chimeras
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - mRNA
KW  - ribonucleic acid
KW  - RNASE
KW  - solid phase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014890&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for male breast cancer (United States).
AU  - Hsing, A. W.
AU  - McLaughlin, J. K.
AU  - Cocco, P.
AU  - Chien, H. T. C.
AU  - Fraumeni, J. F., Jr.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1998///
VL  - 9
IS  - 3
SP  - 269
EP  - 275
SN  - 0957-5243
AD  - Hsing, A. W.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Blvd., Room 443, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991401723.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Human Nutrition
N2  - A case-control study was conducted to investigate risk factors for breast cancer in men. Based on data from the 1986 National (United States) Mortality Followback Survey (NMFS) of almost 20 000 deceased adults (age 25 years or over), information obtained from next-of-kin interviews of 178 men who died of breast cancer was compared with that of 512 male controls who died of other causes. Information was obtained on selected demographic and other factors, including diet, exercise, occupation, height and weight and use of tobacco and alcohol. Increased risks were found for men who were described by their next-of-kin as very overweight (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-5.0). The risks associated with the 3 upper quartiles of body mass index (BMI) were 1.3, 1.6 and 2.3, respectively, with a significant dose-response relationship (P&lt;0.01). An excess risk was also associated with limited exercise (OR = 1.3, CI = 0.8-2.0). Consumption of red meat was associated with an increased risk and consumption of fruits and vegetables with a decreased risk, although the trends were not significant. No association was found for tobacco or alcohol use, but an excess risk was associated with higher levels of socioeconomic status (OR = 1.8, CI = 1.1-3.0). The study suggests that obesity increases the risk of male breast cancer, possibly through hormonal mechanisms, while dietary factors, physical activity and SES indicators also play a part.
KW  - alcohol intake
KW  - anthropometric dimensions
KW  - body weight
KW  - diet
KW  - diet studies
KW  - fruit
KW  - lifestyle
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - men
KW  - mortality
KW  - neoplasms
KW  - obesity
KW  - occupations
KW  - physical activity
KW  - risk
KW  - risk factors
KW  - tobacco smoking
KW  - vegetables
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - alcohol consumption
KW  - anthropometric measurements
KW  - cancers
KW  - death rate
KW  - fatness
KW  - mammary tumour
KW  - United States of America
KW  - vegetable crops
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991401723&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions.
AU  - Smith, M. A.
AU  - Simon, R.
AU  - Strickler, H. D.
AU  - McQuillan, G.
AU  - Ries, L. A. G.
AU  - Linet, M. S.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1998///
VL  - 9
IS  - 3
SP  - 285
EP  - 298
SN  - 0957-5243
AD  - Smith, M. A.: Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992001481.  Publication Type: Journal Article.  Language: English.  Number of References: 115 ref.
N2  - Infection patterns for hepatitis A virus (HAV) were used to indicate hygiene conditions in different populations, with emphasis on instructive USA and Japanese data. A catalytic model was fitted to these data, estimating the HAV force of infection and age-specific seroprevalence rates over time. These analyses were used to assess the temporal relationship of changes in HAV infection rates to changes in childhood leukaemia mortality and incidence rates. An inverse relationship was observed between HAV infection prevalence and rates of childhood leukaemia. Further, decreases in the HAV force of infection in the USA and Japan appeared to have preceded increases in childhood leukaemia rates. A model is described based on a putative leukaemia-inducing agent with a change in infection rate over time correlated with that of HAV that describes the temporal trends in childhood leukaemia rates for white children in the US and for Japanese children. It is suggested that improved public hygiene conditions, as measured by decreased prevalence of HAV infection, are associated with higher childhood acute lymphoblastic leukaemia (ALL) incidence rates. The model presented supports the plausibility of the hypothesis that decreased childhood exposure to a leukaemia-inducing agent associated with hygiene conditions leads to higher rates of ALL in children by increasing the frequency of in utero transmission caused by primary infection during pregnancy (or by increasing the number of individuals infected in early infancy because of lack of protective maternal antibodies).
KW  - children
KW  - epidemiology
KW  - hepatitis A
KW  - human diseases
KW  - hygiene
KW  - incidence
KW  - neoplasms
KW  - Japan
KW  - USA
KW  - hepatitis A virus
KW  - man
KW  - Hepatovirus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - North America
KW  - America
KW  - acute lymphoblastic leukaemia
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001481&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary exposure models for nitrates and nitrites.
AU  - Pennington, J. A. T.
JO  - Food Control
JF  - Food Control
Y1  - 1998///
VL  - 9
IS  - 6
SP  - 385
EP  - 395
SN  - 0956-7135
AD  - Pennington, J. A. T.: Division of Nutrition Research Coordination, National Institutes of Health, Natcher Building, Room 5AN32A, 45 Center Drive, Bethesda, MD 20892-6600, USA.
N1  - Accession Number: 19981418766.  Publication Type: Journal Article.  Language: English.  Number of References: 122 ref. Registry Number: 14797-55-8.  Subject Subsets: Human Nutrition
N2  - Models to assess dietary exposure of population groups to nitrates and nitrites should be based on the major sources of these substances in foods. Most models require the use of food consumption information and will, therefore, be flawed by the problems that exist with current dietary intake assessment methods. The Total Diet Study model would probably not provide representative coverage of the nitrites in processed meats. A nitrate/nitrite database model requires the gathering and compiling of published data and data from industry on the nitrate and nitrite content of foods. A nitrate/nitrite core food model requires the identification of the foods most responsible for nitrate/nitrite consumption in the U.S. and routine collection and analyses of these products. The large database model uses the database of a national food consumption survey and assigns nitrate and nitrite values to all the foods (based on available data and imputation). A processed meat production/consumption model focuses only on nitrites added to processed, cured meats. The nitrate/nitrite core food model is the preferred approach.
KW  - analytical methods
KW  - consumption
KW  - diet
KW  - estimation
KW  - exposure
KW  - food contamination
KW  - foods
KW  - intake
KW  - mathematical models
KW  - meat products
KW  - models
KW  - nitrate
KW  - nitrates
KW  - nitrite
KW  - nitrites
KW  - sources
KW  - surveys
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - food contaminants
KW  - Human Nutrition (General) (VV100) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418766&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 2 lentivirus vectors for gene transfer: expression and potential for helper virus-free packaging.
AU  - Arya, S. K.
AU  - Zamani, M.
AU  - Kundra, P.
JO  - Human Gene Therapy
JF  - Human Gene Therapy
Y1  - 1998///
VL  - 9
IS  - 9
SP  - 1371
EP  - 1380
SN  - 1043-0342
AD  - Arya, S. K.: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, NIH 37 Convent Drive MSC 4255, Bldg 37, Rm 6A11, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19982010711.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 63231-63-0. 
N2  - HIV-2 lentivirus contains elements in its leader sequence located both upstream and downstream of the splice donor sites that participate in RNA encapsidation. These elements appeared to be necessary and sufficient for packaging. Deletion of both upstream and downstream elements was clearly beneficial for curtailing helper virus protection, although this was accompanied by some but acceptable loss of expression capability. The helper virus-free phenotype of the packaging vector could be further ensured without additional loss of expression by replacing the 3′ long terminal repeat with a mini-gene containing a heterologous transcriptional termination signal and a selection marker gene. Relevant to the design of transfer vector, deletion of the splice donor site itself had a dramatic negative effect of viral gene expression.
KW  - antiviral agents
KW  - disease vectors
KW  - gene expression
KW  - gene therapy
KW  - gene transfer
KW  - human diseases
KW  - phenotypes
KW  - RNA
KW  - vectors
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010711&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis.
AU  - Walker, P. S.
AU  - Scharton-Kersten, T.
AU  - Rowton, E. D.
AU  - Hengge, U.
AU  - Bouloc, A.
AU  - Udey, M. C.
AU  - Vogel, J. C.
JO  - Human Gene Therapy
JF  - Human Gene Therapy
Y1  - 1998///
VL  - 9
IS  - 13
SP  - 1899
EP  - 1907
SN  - 1043-0342
AD  - Walker, P. S.: Dermatology Branch, NCI, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20000809301.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9008-11-1, 207137-56-2.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Cell-mediated immunity to Leishmania major was induced by injecting BALB/c mice intradermally with plasmid DNA expressing the conserved L. major cell surface glycoprotein gp63 (gp63-pcDNA-3). CD4 T lymphocytes from gp63-pcDNA-3-immunized mice proliferated and produced IFN (interferon)-γ (but not IL (interleukin)-4) when stimulated in vitro with freeze-thawed parasites, consistent with a Th1 immune response. In contrast, lymphocyte proliferation in animals immunized with freeze-thawed parasites was associated with IL-4 (but not IFN-γ) production, suggesting a nonprotective Th2 response. Challenge studies revealed that gp63-pcDNA-3 vaccination protected 30% of susceptible mice (21 of 70) from Leishmania infection, whereas neither gp63 protein (0 of 20) nor freeze-thawed parasite vaccines (0 of 50) were efficacious. Dendritic cells derived from skin of gp63-pcDNA-3-injected mice and used to immunize naive recipients also protected them from leishmaniasis. It is concluded that gp63-pcDNA-3 genetic vaccination results in a CD4-dependent Th1 immune response that correlates with protection from disease, and suggested that skin-derived dendritic cells are involved in priming this response.
KW  - antigen gp63
KW  - CD4+ lymphocytes
KW  - cell mediated immunity
KW  - DNA vaccines
KW  - glycoproteins
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - interferon
KW  - interleukin 4
KW  - leishmaniasis
KW  - lymphocyte transformation
KW  - plasmid vectors
KW  - skin
KW  - surface antigens
KW  - surface proteins
KW  - T lymphocytes
KW  - vaccination
KW  - vaccine development
KW  - Leishmania major
KW  - mice
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - CD4+ cells
KW  - cellular immunity
KW  - dermis
KW  - gp63
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - leishmaniosis
KW  - membrane proteins
KW  - T cells
KW  - T4 lymphocytes
KW  - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW  - Animal Models of Human Diseases (VV400) (New March 2000)
KW  - Animal Immunology (LL650) (New March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000809301&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - World Health Organization Classification of lymphomas: a work in progress.
AU  - Jaffe, E. S.
AU  - Harris, N. L.
AU  - Diebold, J.
AU  - Müller-Hermelink, H. K.
A2  - Engert, A.
A2  - Parsa-Parsi, R.
A2  - Diehl, V.
JO  - Annals of Oncology
JF  - Annals of Oncology
Y1  - 1998///
VL  - 9
IS  - Suppl. 5
SP  - S25
EP  - S30
SN  - 0923-7534
AD  - Jaffe, E. S.: Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19992004157.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 31 ref.
KW  - classification
KW  - human diseases
KW  - lymphoma
KW  - neoplasms
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004157&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of molecular strategies to develop a live dengue vaccine.
AU  - Lai, C. J.
AU  - Bray, M.
AU  - Men, R.
AU  - Cahour, A.
AU  - Chen, W.
AU  - Kawano, H.
AU  - Tadano, M.
AU  - Hiramatsu, K.
AU  - Tokimatsu, I.
AU  - Pletnev, A.
AU  - Arakai, S.
AU  - Shameem, G.
AU  - Rinaudo, M.
A2  - Zeytin, F. N.
A2  - Gerlich, W.
JO  - Clinical and Diagnostic Virology
JF  - Clinical and Diagnostic Virology
Y1  - 1998///
VL  - 10
IS  - 2/3
SP  - 173
EP  - 179
SN  - 0928-0197
AD  - Lai, C. J.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990502612.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 25 ref. Registry Number: 63231-63-0.  Subject Subsets: Medical & Veterinary Entomology
N2  - A study was conducted to use the successful construction of dengue type 4 virus (DEN4) cDNA, which yields infectious RNA transcripts, to provide a new approach to the development of safe and effective dengue vaccines. The 3′ and 5′ noncoding (NC) regions of the genome were targeted to construct DEN4 deletion mutants, because the sequences in these regions are thought to play an important role in the regulation of viral replication. DEN4 cDNA was also employed to construct a viable chimaeric virus with dengue type 1, 2 or 3 antigenicity, by substitution of heterotypic structural protein genes. Most viable mutants, recovered from the cDNA constructs, were partially restricted for growth in simian cells as analysed by plaque morphology assay and viral yield analysis. Several 3′ NC deletion mutants which exhibited a range of growth restriction in cell culture were further evaluated for infectivity and immunogenicity in rhesus monkeys. Occurrence and duration of viraemia were reduced for these deletion mutants, compared to the wild type DEN4. Analysis of antibody response to infection in rhesus monkeys also indicated that some of these mutants were attenuated. These DEN4 deletion mutants represent promising live dengue vaccine candidates that merit further clinical evaluation. Chimaera DEN1/DEN4 or DEN2/DEN4 which expresses DEN1 or DEN2 antigenicity were also used to infect monkeys. Most monkeys immunised with these chimaeric viruses, singly or in combination, developed high titres of neutralising antibodies and were protected against homotypic wild type DEN1 or DEN2 challenge. It was concluded that DEN4 and its derived chimaeric viruses of other 3 dengue serotype specificity, that contain appropriate attenuating mutations, have a potential use in a tetravalent live vaccine against dengue.
KW  - arboviruses
KW  - chimaeras
KW  - immune response
KW  - immunization
KW  - laboratory animals
KW  - mutants
KW  - RNA
KW  - vaccines
KW  - viral proteins
KW  - dengue 1 virus
KW  - dengue 2 virus
KW  - dengue 3 virus
KW  - dengue 4 virus
KW  - dengue virus
KW  - Macaca mulatta
KW  - monkeys
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - chimeras
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - ribonucleic acid
KW  - structural proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502612&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene therapy for infectious diseases.
AU  - Bunnell, B. A.
AU  - Morgan, R. A.
JO  - Clinical Microbiology Reviews
JF  - Clinical Microbiology Reviews
Y1  - 1998///
VL  - 11
IS  - 1
SP  - 42
EP  - 56
SN  - 0893-8512
AD  - Bunnell, B. A.: Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-1851, USA.
N1  - Accession Number: 19982006318.  Publication Type: Journal Article.  Language: English.  Number of References: 165 ref. Subject Subsets: Public Health
N2  - A review of gene therapy is presented and anti-human immunodeficiency virus (HIV) gene therapy is discussed extensively. Areas considered are: nucleic acid-based genetic therapy (antisense DNA and RNA, ribozymes, and RNA decoys); protein-based approaches to gene therapy (transdominant negative proteins, anti-infectious cellular proteins, single-chain antibodies, and suicide genes); immunotherapy (DNA vaccines and agent-specific cytotoxic T cells); and target pathogens for antimicrobial gene therapy (HIV, human T cell lymphotropic virus, influenza virus, human papillomavirus, hepatitis B and C viruses, herpes simplex virus, Epstein-Barr virus, cytomegalovirus, Mycobacterium tuberculosis). Examples of clinical trials for infectious disease are presented, including marking of syngeneic T cells, transdominant negative Rev and gene vaccines.
KW  - gene therapy
KW  - human diseases
KW  - infectious diseases
KW  - reviews
KW  - vaccines
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - communicable diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006318&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Does Chlamydia pneumoniae cause coronary heart disease?
AU  - Quinn, T. C.
JO  - Current Opinion in Infectious Diseases
JF  - Current Opinion in Infectious Diseases
Y1  - 1998///
VL  - 11
IS  - 3
SP  - 301
EP  - 307
SN  - 0951-7375
AD  - Quinn, T. C.: National Institute of Allergy and Infectious Diseases, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
N1  - Accession Number: 19992000316.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref.
KW  - atherosclerosis
KW  - epidemiology
KW  - heart diseases
KW  - human diseases
KW  - pathogenesis
KW  - pathology
KW  - reviews
KW  - Chlamydophila pneumoniae
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Chlamydophila
KW  - Chlamydiaceae
KW  - Chlamydiales
KW  - Chlamydiae
KW  - Bacteria
KW  - prokaryotes
KW  - arteriosclerosis
KW  - bacterium
KW  - Chlamydia pneumoniae
KW  - coronary diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pain as a complication of HIV disease.
AU  - Hirschfeld, S.
JO  - AIDS Patient Care and STDs
JF  - AIDS Patient Care and STDs
Y1  - 1998///
VL  - 12
IS  - 2
SP  - 91
EP  - 108
AD  - Hirschfeld, S.: National Cancer Institute, Bldg 10, Rm 13N240, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982004315.  Publication Type: Journal Article.  Language: English.  Number of References: 208 ref.
N2  - Pain as a symptom is common to many pathological conditions. At its most elementary level, it is a signal from peripheral nerves with specialized receptors that there is a change in the local environment, such as pressure, pH, temperature, or some other noxious stimulus, that can be detrimental to function. Pain is particularly prevalent in patients with HIV infection. The assessment, evaluation, and treatment of pain should be an integral part of comprehending patient care. Therapy for pain should be directed toward treating the underlying cause. Analgesia should be multimodal. As pharmacology research provides agents with greater specificity and presumably fewer side effects, the functional status of patients is expected to benefit. The treatment of pain is a tacit contract with the patient that the diminution of quality of life will be addressed. It is critical for health care providers to anticipate and recognize the symptoms and effects of pain and to request specialized consultation for refractory problems. A number of hospitals and foundations have begun continuing education programmes to provide instruction and outreach to health care providers who are charged with the care of those with HIV infection. The effects of satisfactory treatment can be profound. There are anecdotal reports of patients whose entire affect, appetite and quality of life changed once it was recognized that pain was an inhibitor of function.
KW  - acquired immune deficiency syndrome
KW  - adverse effects
KW  - health care
KW  - HIV infections
KW  - hospitals
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - pain
KW  - patient care
KW  - patients
KW  - peripheral nerves
KW  - pharmacology
KW  - symptoms
KW  - temperature
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - nerves
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004315&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - CCR-5 genotype and sexual transmission of HIV-1.
AU  - O'Brien, T. R.
AU  - Padian, N. S.
AU  - Hodge, T.
AU  - Goedert, J. J.
AU  - O'Brien, S. J.
AU  - Carrington, M.
T2  - AIDS
JO  - AIDS
JF  - AIDS
Y1  - 1998///
VL  - 12
IS  - 4
SP  - 444
EP  - 445
SN  - 0269-9370
AD  - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA.
N1  - Accession Number: 19982004359.  Publication Type: Correspondence.  Language: English.  Number of References: 6 ref.
N2  - In this study, with a total of 283 female sex partners of HIV-1-infected men, no evidence was found to suggest that the risk of acquiring HIV-1 through heterosexual intercourse was decreased in women who are heterozygous for CCR-5 Δ32.
KW  - alleles
KW  - chemokines
KW  - cytokines
KW  - heterosexual transmission
KW  - HIV-1 infections
KW  - human diseases
KW  - infectivity
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004359&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Abdominal presentation of Burkitt's lymphoma in an HIV-positive patient.
AU  - Saif, M. W.
AU  - Greenberg, B. R.
JO  - AIDS Patient Care and STDs
JF  - AIDS Patient Care and STDs
Y1  - 1998///
VL  - 12
IS  - 7
SP  - 567
EP  - 571
AD  - Saif, M. W.: National Cancer Institute, 4700 Bradley Blvd., Chevy Chase, MD 20815, USA.
N1  - Accession Number: 19982011076.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref.
N2  - A case is described of a patient with HIV infection who presented with abdominal pain and distension and was found to have an intraabdominal type of Burkitt's lymphoma.
KW  - abdomen
KW  - acquired immune deficiency syndrome
KW  - Burkitt's lymphoma
KW  - case reports
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphoma
KW  - neoplasms
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - cancers
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011076&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pilot study of the immunologic effects of recombinant human growth hormone and recombinant insulin-like growth factor in HIV-infected patients.
AU  - Nguyen, B. Y.
AU  - Clerici, M.
AU  - Venzon, D. J.
AU  - Bauza, S.
AU  - Murphy, W. J.
AU  - Longo, D. L.
AU  - Baseler, M.
AU  - Gesundheit, N.
AU  - Broder, S.
AU  - Shearer, G.
AU  - Yarchoan, R.
JO  - AIDS
JF  - AIDS
Y1  - 1998///
VL  - 12
IS  - 8
SP  - 895
EP  - 904
SN  - 0269-9370
AD  - Nguyen, B. Y.: HIV and AIDS Malignancy Branch, Bldg 10, Rm 12N226, National Institutes of Health, Bethesda MD 20892-1906, USA.
N1  - Accession Number: 19982008033.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 61912-98-9, 9002-72-6. 
N2  - In a randomized but not blinded trial 24 HIV-infected patients with CD4+ cell counts of 100×400×106/l who were receiving nucleoside antiretroviral therapy were given recombinant human growth hormone (rhGH), recombinant human insulin-like growth factor type 1 (rhlGF-1), or the combination administered subcutaneously for 12 weeks. Plasma IGF-1 levels were low or low-normal prior to treatment and increased with all 3 therapies. There were no significant changes in CD4+ cell counts, RA/RO CD4+ cell subsets, natural killer cell function, immunoglobin levels, or in vitro interleukin-2 production in response to mitogen or alloantigens. However, there was an upward trend (and for p18IIIB a statistically significant increase) in the in vitro IL-2 production in response to each of 5 HIV envelope peptides. Potential toxic effects included fatigue, arthralgia, oedema, myalgia, and headache. Patients also were noted to have weight gain averaging 4 kg early in the course of treatment. These results suggest that treatment with rhGH/rhIGF-1 was reasonably well tolerated and that modest improvement in HIV-specific immune function was attained.
KW  - adverse effects
KW  - antiviral agents
KW  - blood plasma
KW  - CD4+ lymphocytes
KW  - growth factors
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunotherapy
KW  - insulin-like growth factor
KW  - interleukins
KW  - leukocyte count
KW  - mitogens
KW  - peptides
KW  - somatotropin
KW  - T lymphocytes
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - CD4+ cells
KW  - cell count
KW  - growth hormone
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - plasma (blood)
KW  - somatomedin C
KW  - T cells
KW  - T4 lymphocytes
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An update on drug interactions with zidovudine.
AU  - Piscitelli, S. C.
AU  - Polis, M. A.
JO  - AIDS Patient Care and STDs
JF  - AIDS Patient Care and STDs
Y1  - 1998///
VL  - 12
IS  - 9
SP  - 687
EP  - 690
AD  - Piscitelli, S. C.: Laboratory of Immunoregulation, National Institutes of Health, Bldg 10, Rm. 11C103, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014258.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 30516-87-1. 
KW  - adverse effects
KW  - antiviral agents
KW  - drug antagonism
KW  - drug combinations
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - AZT
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014258&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques.
AU  - Heyes, M. P.
AU  - Saito, K.
AU  - Lackner, A.
AU  - Wiley, C. A.
AU  - Achim, C. L.
AU  - Markey, S. P.
JO  - FASEB Journal
JF  - FASEB Journal
Y1  - 1998///
VL  - 12
IS  - 10
SP  - 881
EP  - 896
SN  - 0892-6638
AD  - Heyes, M. P.: Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982012882.  Publication Type: Journal Article.  Language: English.  Number of References: 72 ref.
N2  - The results of this study demonstrate a role for induction of indoleamine-2,3-dioxygenase in accelerating the local formation of quinolinic acid within the brain tissue, particularly in areas of encephalitis, rather than entry of quinolinic acid into the brain from the meninges or blood. Strategies to reduce quinolinic acid production, targeted at intracerebral sites, are potential approaches to therapy.
KW  - brain
KW  - cerebrospinal fluid
KW  - cytokines
KW  - encephalitis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - macrophages
KW  - metabolites
KW  - nervous system diseases
KW  - neurotoxicity
KW  - neurotoxins
KW  - pathogenesis
KW  - Macaca
KW  - Macaca mulatta
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Macaca
KW  - Homo
KW  - Hominidae
KW  - cerebrum
KW  - encephalomyelitis
KW  - human immunodeficiency virus
KW  - neuropathy
KW  - quinolinic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012882&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Individual prognoses of long-term responses to antiretroviral treatment based on virological, immunological and pharmacological parameters measured during the first week under therapy.
AU  - Mueller, B. U.
AU  - Zeichner, S. L.
AU  - Kuznetsov, V. A.
AU  - Heath-Chiozzi, M.
AU  - Pizzo, P. A.
AU  - Dimitrov, D. S.
JO  - AIDS
JF  - AIDS
Y1  - 1998///
VL  - 12
IS  - 15
SP  - F191
EP  - F196
SN  - 0269-9370
AD  - Mueller, B. U.: Laboratory of Experimental and Computational Biology, Division of Basic Sciences, National Cancer Institute-FCRDC, Building 469, Room 216, Miller Drive, PO Box B, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982014343.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 63231-63-0, 155213-67-5. 
N2  - Forty one HIV-1-infected children were treated with ritonavir for 12 weeks followed by triple drug combination treatment, and the kinetics of virus decay in plasma, ritonavir concentration and CD4+ cell counts were measured. A robust multivariate pattern recognition method was used for prediction of the long-term virological responses. The virus decay rate constants calculated from measurements of plasma viral RNA concentrations on the first, second, third, fourth and seventh day on therapy, the drug concentrations in the plasma on day 7, and the pretreatment levels of viral RNA and CD4+ cell counts, correlated with long-term levels of plasma HIV-1 RNA. The combination of these parameters contained sufficient information for correct and robust prediction of the long-term response in 88% of the treated children. The predictions of individual responses were stable as demonstrated by a cross-validation analysis, which was highly statistically significant (r = 0.87) and specific.
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - children
KW  - combination therapy
KW  - disease course
KW  - drug therapy
KW  - human diseases
KW  - immune response
KW  - leukocyte count
KW  - prognosis
KW  - prognostic markers
KW  - proteinase inhibitors
KW  - ritonavir
KW  - RNA
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4+ cells
KW  - cell count
KW  - chemotherapy
KW  - combined modality therapy
KW  - disease progression
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - multimodal treatment
KW  - protease inhibitors
KW  - ribonucleic acid
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014343&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protease inhibitor and triple-drug therapy: cellular immune parameters are not restored in pediatric AIDS patients after 6 months of treatment.
AU  - Chougnet, C.
AU  - Fowke, K. R.
AU  - Mueller, B. U.
AU  - Smith, S.
AU  - Zuckerman, J.
AU  - Jankelevitch, S.
AU  - Steinberg, S. M.
AU  - Luban, N.
AU  - Pizzo, P. A.
AU  - Shearer, G. M.
JO  - AIDS
JF  - AIDS
Y1  - 1998///
VL  - 12
IS  - 18
SP  - 2397
EP  - 2406
SN  - 0269-9370
AD  - Chougnet, C.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992002440.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 130068-27-8, 308079-78-9, 150378-17-9, 155213-67-5.  Subject Subsets: Public Health
N2  - To assess whether treatment of HIV-positive children with antiretroviral drugs for a 6-month period would improve immune function significantly, an immunological assessment of 89 HIV-positive children who received protease inhibitor (indinavir or ritonavir) monotherapy for 12-16 weeks as part of phase I/II studies, followed by triple antiretroviral therapy for an additional 12 weeks, was conducted in the USA [date not given]. Immunological parameters were assessed in vitro at 4 time points (at enrolment, at weeks 2-4, at weeks 12-16, and at weeks 24-28). Assessments included: cytokine production by monocytes, T-cell proliferation to mitogen or recall antigens (including an HIV antigen), and apoptotic cell death. Plasma levels of tumour necrosis factor (TNF)-α and soluble TNF receptor (sTNF-R) were also measured, in addition to CD4+ T-lymphocyte counts and viral load. In addition, limited analyses were performed on samples from 17 children after 120 weeks of therapy, including 104 weeks of triple therapy. At enrolment, the 89 children exhibited severe immune defects. Antiretroviral therapy raised CD4+ T-lymphocyte counts significantly and decreased viral loads. In contrast, the in vitro immune parameters studied were not improved, except for plasma levels of sTNF-RII which decreased in parallel with the decrease in viral load. In addition, there was a trend towards increased skin test reactivity for the ritonavir-treated children. No differences were seen in the immune parameters whether the patients were treated with mono- or triple therapy. Results obtained after 120 weeks of therapy demonstrated that defective interleukin-12 production was not restored by long-term therapy.
KW  - apoptosis
KW  - CD4+ lymphocytes
KW  - cell mediated immunity
KW  - children
KW  - cytokines
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - indinavir
KW  - interleukin 10
KW  - interleukin 12
KW  - interleukins
KW  - proteinase inhibitors
KW  - ritonavir
KW  - tumour necrosis factor
KW  - viral diseases
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cachectin
KW  - cachexin
KW  - CD4+ cells
KW  - cellular immunity
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - protease inhibitors
KW  - T4 lymphocytes
KW  - tumor necrosis factor
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002440&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of guidelines for initiation of highly active antiretroviral therapy in a longitudinal cohort of HIV-infected individuals.
AU  - Ioannidis, J. P. A.
AU  - O'Brien, T. R.
AU  - Goedert, J. J.
JO  - AIDS
JF  - AIDS
Y1  - 1998///
VL  - 12
IS  - 18
SP  - 2417
EP  - 2423
SN  - 0269-9370
AD  - Ioannidis, J. P. A.: HIV Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992002441.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Public Health
N2  - To evaluate several expert-developed guidelines for initiating highly active antiretroviral therapy (HAART) in patients with HIV infection, the application of such guidelines was simulated in a cohort of HIV-infected patients established and followed before HAART was available; the patients' survival without disease progression was evaluated in the absence of HAART. Longitudinal data were used that had been collected from 1982 to 1995 on a prospective cohort of 133 homosexual men from New York and District of Columbia (USA) with known or closely approximated dates of HIV-1 seroconversion and negligible antiretroviral exposure. The main definition of disease progression was CD4 cell count ≤300 × 106/litre or development of clinical AIDS diagnosis within 12 months. The mean number of years between the recommended initiation of therapy and when disease progression occurred in the absence of HAART were as follows: initiation of treatment at first visit, 4.81 years; CD4 cell count &lt;500 × 106/litre or serum RNA &gt;5000 copies/ml (at least 10 000 copies/ml fresh plasma), 4.35 years; CD4+ cells &lt;500 × 106/litre or serum RNA &gt;20 000 copies/ml (at least 40 000 copies/ml fresh plasma), 3.61 years; and CD4+ cells &lt;500 × 106/litre, 2.72 years. The percentage of patients who had disease progression before HAART would have been recommended was 0.8, 1.6, 3.2 and 13.6% with each of these 4 approaches, respectively. It is concluded that implementation of recommended treatment guidelines will result in a substantial proportion of patients being treated for long periods before immunological or clinical disease progression would have occurred in the absence of HAART.
KW  - antiviral agents
KW  - disease course
KW  - disease models
KW  - drug therapy
KW  - guidelines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - viral diseases
KW  - District of Columbia
KW  - New York
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - chemotherapy
KW  - disease progression
KW  - human immunodeficiency virus
KW  - recommendations
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002441&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Life without white fat: a transgenic mouse.
AU  - Moitra, J.
AU  - Mason, M. M.
AU  - Olive, M.
AU  - Krylov, D.
AU  - Gavrilova, O.
AU  - Marcus-Samuels, B.
AU  - Feigenbaum, L.
AU  - Lee, E.
AU  - Aoyama, T.
AU  - Eckhaus, M.
AU  - Reitman, M. L.
AU  - Vinson, C.
JO  - Genes & Development
JF  - Genes & Development
Y1  - 1998///
VL  - 12
IS  - 20
SP  - 3168
EP  - 3181
SN  - 0890-9369
AD  - Moitra, J.: Laboratory of Biochemistry, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892 USA.
N1  - Accession Number: 19981417962.  Publication Type: Journal Article.  Language: English.  Number of References: 2 pp. of ref. Registry Number: 50-99-7, 9004-10-8, 169494-85-3.  Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2  - A transgenic mouse with no white fat tissue throughout life is described. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2 enhancer/promoter. This protein prevents the DNA binding of B-ZIP transcription factors of both the C/EBP and Jun families. The transgenic mice (named A-ZIP/F-1) have no white adipose tissue and dramatically reduced amounts of brown adipose tissue, which is inactive. They are initially growth delayed, but by week 12, surpass their littermates in weight. The mice eat, drink, and urinate copiously, have decreased fecundity, premature death, and frequently die after anesthesia. The physiological consequences of having no white fat tissue are profound. The liver is engorged with lipid, and the internal organs are enlarged. The mice are diabetic, with reduced leptin (20-fold) and elevated serum glucose (3-fold), insulin (50- to 400-fold), free fatty acids (2-fold), and triglycerides (3- to 5-fold). The A-ZIP/F-1 phenotype suggests a mouse model for the human disease lipoatrophic diabetes (Seip-Berardinelli syndrome), indicating that the lack of fat can cause diabetes. The myriad of consequences of having no fat throughout development can be addressed with this model.
KW  - adipocytes
KW  - biotechnology
KW  - blood sugar
KW  - body fat
KW  - diabetes
KW  - fatty acids
KW  - genetically engineered organisms
KW  - glucose
KW  - insulin
KW  - leptin
KW  - phenotypes
KW  - transgenic animals
KW  - triacylglycerols
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood glucose
KW  - dextrose
KW  - fat cells
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - glucose in blood
KW  - GMOs
KW  - transgenic organisms
KW  - triglycerides
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417962&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells.
AU  - Al-Harthi, L.
AU  - Owais, M.
AU  - Arya, S. K.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1998///
VL  - 14
IS  - 1
SP  - 59
EP  - 64
SN  - 0889-2229
AD  - Al-Harthi, L.: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982003039.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - HIV-2 inhibited both the production of extracellular HIV-1 p24 antigen and intracellular viral RNA, suggesting the involvement of transcriptional downmodulation. Some of the defective HIV-2 proviruses also inhibited HIV-1. In some cases, these defects were transcomplemented by the corresponding HIV-1 gene products, emphasizing cross-regulation between the two viruses. The phenotype of one of the mutant HIV-1 proviruses suggested that posttranscriptional effects may also occur. In addition to the possible HIV-2 suppression of HIV-1 in vivo by cross-protective immune mechanisms, intracellular inhibition, noted here, may be another line of defence.
KW  - antigens
KW  - core protein p24
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - interactions
KW  - phenotypes
KW  - proviruses
KW  - Human immunodeficiency virus 1
KW  - Human immunodeficiency virus 2
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - antigenicity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - human immunodeficiency virus type 2
KW  - immunogens
KW  - p24
KW  - p24 antigen
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003039&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of 3D QSAR methodology for data mining the National Cancer Institute Repository of Small Molecules: application to HIV-1 reverse transcriptase inhibition.
AU  - Gussio, R.
AU  - Pattabiraman, N.
AU  - Kellogg, G. E.
AU  - Zaharevitz, D. W.
JO  - Methods, A Companion to Methods in Enzymology
JF  - Methods, A Companion to Methods in Enzymology
Y1  - 1998///
VL  - 14
IS  - 3
SP  - 255
EP  - 263
AD  - Gussio, R.: Target Structure-Based Drug Discovery Group, Information Technology Branch, Developmental Therapeutics Program, National Cancer Institute, 811 Executive Plaza North, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19982008466.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
KW  - antiviral agents
KW  - databases
KW  - enzyme inhibitors
KW  - human diseases
KW  - inhibition
KW  - methodology
KW  - reverse transcriptase inhibitors
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - data banks
KW  - human immunodeficiency virus type 1
KW  - methods
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008466&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lessons from the cat: feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1.
AU  - Elder, J. H.
AU  - Dean, G. A.
AU  - Hoover, E. A.
AU  - Hoxie, J. A.
AU  - Malim, M. H.
AU  - Mathes, L.
AU  - Neil, J. C.
AU  - North, T. W.
AU  - Sparger, E.
AU  - Tompkins, M. B.
AU  - Tompkins, W. A. F.
AU  - Yamamoto, J.
AU  - Yuhki, N.
AU  - Pedersen, N. C.
AU  - Miller, R. H.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1998///
VL  - 14
IS  - 9
SP  - 797
EP  - 801
SN  - 0889-2229
AD  - Elder, J. H.: Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982010447.  Publication Type: Journal Article.  Language: English. 
N2  - In July 1997 the Division of AIDS of the National Institute of Allergy and Infectious Diseases in the USA sponsored a workshop entitled "Use of the FIV/cat model for development of anti-HIV vaccines and therapeutics." The purpose of this workshop was to provide a forum for presenting new data arising from FIV research, assess the utility of the FIV/cat model, identify areas applicable to HIV/AIDS research, and solicit input from investigators on scientific gaps that can benefit from additional support. The meeting brought to the fore numerous areas where the FIV/cat model can serve as a valuable tool for developing new therapeutic strategies and vaccine designs applicable to the treatment and prevention of HIV-1 infection.
KW  - animal models
KW  - human immunodeficiency viruses
KW  - pathogenesis
KW  - research
KW  - therapy
KW  - vaccines
KW  - cats
KW  - feline immunodeficiency virus
KW  - Retroviridae
KW  - Felis
KW  - Felidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - studies
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010447&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The search for novel malaria transmission-blocking targets in the mosquito midgut.
AU  - Shahabuddin, M.
AU  - Cociancich, S.
AU  - Zieler, H.
JO  - Parasitology Today
JF  - Parasitology Today
Y1  - 1998///
VL  - 14
IS  - 12
SP  - 493
EP  - 497
AD  - Shahabuddin, M.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990800523.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Recent studies to identify the cellular and biochemical factors that affect the malaria parasite's development in the mosquito are summarized, with particular reference to factors influencing the early development of Plasmodium, receptor-mediated interactions between the parasite and the mosquito midgut, and the gut-associated immune responses directed against Plasmodium.
KW  - biological development
KW  - disease vectors
KW  - host parasite relationships
KW  - interactions
KW  - midgut
KW  - parasites
KW  - reviews
KW  - transmission blocking immunity
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - parasite host relationships
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990800523&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine profiles in HIV type 1 disease and protection.
AU  - Shearer, G. M.
AU  - Clerici, M.
JO  - AIDS Research and Human Retroviruses
JF  - AIDS Research and Human Retroviruses
Y1  - 1998///
VL  - 14
IS  - sup.2
SP  - S149
EP  - S152
SN  - 0889-2229
AD  - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982010984.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
KW  - cytokines
KW  - human diseases
KW  - immune response
KW  - immunity
KW  - immunopathology
KW  - immunotherapy
KW  - interleukins
KW  - reviews
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010984&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evolution of a common structural core in the internal ribosome entry sites of Picornavirus.
AU  - Le ShuYun
AU  - Maizel, J. V., Jr.
JO  - Virus Genes
JF  - Virus Genes
Y1  - 1998///
VL  - 16
IS  - 1
SP  - 25
EP  - 38
SN  - 0920-8569
AD  - Le ShuYun: Laboratory of Mathematical Biology, Division of Cancer Biology Diagnosis and Centers, National Cancer Institute, NIH, Bldg 469, Room 151, Frederick, Maryland 21702.
N1  - Accession Number: 19982206885.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Veterinary Science
N2  - The translational control involving internal ribosome binding occurs in poliovirus (PV), human rhinoviruses (HRV), encephalomyocarditis virus (EMCV), foot-and-mouth disease virus (FMDV), and hepatitis A virus (HAV). Internal ribosome binding utilizes cis-acting genetic elements of approximately 450 nucleotides (nt) termed the internal ribosome entry sites (IRES) found in these picornaviral 5′-untranslated region (5′UTR). Although these IRES elements are quite different in their primary sequence, a similar folding structure with a conserved 3′ structural core exists in the IRES. Phylogenetic analysis and RNA folding of the 5′ UTR of picornaviruses, including PV types 1-3, coxsackievirus types A and B, swine vesicular disease virus, echoviruses, enteroviruses (human and bovine), HRV, HAV, EMCV, mengovirus, Theiler's murine encephalomyelitis viruses, FMDV, and equine rhinoviruses, indicates that the predicted conserved structural core is indeed a general structural feature for all members of the picornavirus family. The evolution of a common structural core likely occurred by the gradual addition or deletion of structural domains and elements to preserve a similar tertiary structure that facilitates the utilization of the IRES in specific host-cell environments.
KW  - evolution
KW  - phylogeny
KW  - Aphthovirus
KW  - Cardiovirus
KW  - Coxsackieviruses
KW  - encephalomyocarditis virus
KW  - Foot-and-mouth disease virus
KW  - human echoviruses
KW  - Picornaviridae
KW  - Poliovirus
KW  - Theilovirus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Enterovirus
KW  - Cardiovirus
KW  - Foot-and-mouth disease virus
KW  - human echovirus
KW  - murine encephalomyelitis virus
KW  - polioviruses
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982206885&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cancer in human immunodeficiency virus-infected children: a case series from the Children's Cancer Group and the National Cancer Institute.
AU  - Granovsky, M. O.
AU  - Mueller, B. U.
AU  - Nicholson, H. S.
AU  - Rosenberg, P. S.
AU  - Rabkin, C. S.
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
Y1  - 1998///
VL  - 16
IS  - 5
SP  - 1729
EP  - 1735
SN  - 0732-183X
AD  - Granovsky, M. O.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6130 Executive Blvd., EPN/434, Rockville, MD 20852, USA.
N1  - Accession Number: 19982009761.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref.
N2  - The Children's Cancer Group (CCG) and the National Cancer Institute (NCI) of the USA were retrospectively surveyed for cases of cancer that occurred between July 1982 and February 1997 in children who were HIV seropositive before or at the time of cancer diagnosis. 64 children (39 boys, 25 girls) with 65 tumours were reported. 37 children (58%) acquired HIV infection vertically (median age at cancer diagnosis, 4.3 years); 22 children (34%) acquired HIV through transfusion of blood or blood products (median age at cancer diagnosis, 13.4 years). 42 children (65%) had non-Hodgkin's lymphoma (NHL). 11 children (17%) had leiomyosarcomas (or leiomyomas), which are otherwise exceptionally rare in children. Other malignancies included acute leukaemia (5 children), Kaposi's sarcoma (3 children), Hodgkin's disease (2 children), vaginal carcinoma in situ (1 child). Median survival after NHL diagnosis was 6 months (range, 1 day to 89 months) and after leiomyosarcoma, 12 months (range, 10 days to 19 months). The average monthly after NHL diagnosis was 12% n the first 6 months, which decreased to about 2% thereafter. In contrast, the monthly death rate after leiomyosarcoma diagnosis increased from 5% in the first 6 months to about 20% thereafter.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - diagnosis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - leukaemia
KW  - lymphoma
KW  - mortality
KW  - neoplasms
KW  - sarcoma
KW  - survival
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - blood cancer
KW  - cancers
KW  - death rate
KW  - human immunodeficiency virus
KW  - leucaemia
KW  - leukemia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009761&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Advances in HIV/AIDS statistical methodology over the past decade.
AU  - Foulkes, M. A.
JO  - Statistics in Medicine
JF  - Statistics in Medicine
Y1  - 1998///
VL  - 17
IS  - 1
SP  - 1
EP  - 25
SN  - 0277-6715
AD  - Foulkes, M. A.: Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Correspondence address; SmithKline Beecham Biologicals, rue de l'Institut, 89, B-1330 Rixensart, Belgium.
N1  - Accession Number: 19982006997.  Publication Type: Journal Article.  Language: English.  Number of References: 358 ref.
N2  - This review provides a synopsis of the developments over the past decade in mathematical and statistical methodology in response to the AIDS epidemic. It includes highlights of the development of epidemic models, approaches to describing the natural history of HIV infection, and the methods developed for HIV therapeutic or prevention research. An extensive bibliography is included. The intention is to provide a historical perspective on the methodological developments and a framework for identifying HIV/AIDS-related needs for the future.
KW  - acquired immune deficiency syndrome
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mathematical models
KW  - methodology
KW  - research
KW  - statistics
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - methods
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006997&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV Tat protein requirements for transactivation and repression of transcription are separable.
AU  - Brown, J. A.
AU  - Howcroft, T. K.
AU  - Singer, D. S.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1998///
VL  - 17
IS  - 1
SP  - 9
EP  - 16
AD  - Brown, J. A.: Moleular Regulation Section, Experimental Immunology Branch, National Cancer Institute, Bldg 10, Rm 4B-17, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982003004.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
N2  - The HIV Tat protein, primarily characterized as a transcriptional activator of the viral long terminal repeat (LTR), is also a potent repressor of major histocompatibility complex (MHC) class I transcription. This study demonstrates that these two functional activities are distinct and mediated by discrete, but overlapping, structural domains of Tat. Tat repressor activity depends on C-terminal sequences, whereas transactivation depends on N-terminal sequences; both functions require core sequences. The repressor activity requires a domain encompassing the region encoded by the second exon of the Tat gene, beginning at amino acid 73, with a C-terminal limit between amino acids 80 and 83. Tat repressor function also depends on the presence of a lysine at position 41, located within the core of the protein. Tat repressor activity is independent of two N-terminal domains essential for transactivation: the acidic segment and the cysteine-rich region. Conversely, Tat transactivation is independent of the second exon-encoded region of Tat. As further support for this novel model of separable Tat functions, it is shown that in murine fibroblasts, Tat represses class I promoter activity, but does not transactivate the HIV LTR. It is proposed that distinct structural domains mediate the two functionally distinct activities associated with the Tat protein.
KW  - amino acids
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - major histocompatibility complex
KW  - promoters
KW  - proteins
KW  - Tat protein
KW  - transactivation
KW  - transcription
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA transcription
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - promoter region
KW  - promoter sequences
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Estimating the cumulative incidence of HIV infection among persons with haemophilia in the United States of America.
AU  - Rosenberg, P. S.
AU  - Goedert, J. J.
JO  - Statistics in Medicine
JF  - Statistics in Medicine
Y1  - 1998///
VL  - 17
IS  - 2
SP  - 155
EP  - 168
SN  - 0277-6715
AD  - Rosenberg, P. S.: National Cancer Institute, 6130 Executive Blvd, EPN/403, Rockville, MD 20852, USA.
N1  - Accession Number: 19982004031.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - Complementary approaches were used to estimate the cumulative incidence of infection with HIV among persons with haemophilia in the USA. One approach, ratio estimation, divided the cumulative number of haemophiliacs diagnosed with AIDS in the USA by the corresponding cumulative proportion with AIDS among HIV-positive subjects in the Multicenter Hemophilia Cohort Study (MHCS). The other approach, back-calculation, reconstructed past HIV incidence from national surveillance of AIDS using essentially non-parametric estimates of the hazard functions for AIDS and for pre-AIDS death. Confidence intervals were derived that fully incorporated uncertainty about the hazard functions. Results from the 2 approaches were consistent. Around 9200 haemophiliacs became infected during the course of the epidemic. Of them, around 7000 were living with HIV or AIDS as of 31 December 1992 and at least 5630 as of 31 December 1995. Credible calculations for this group must account for those who die before AIDS and for the significantly longer incubation times in those infected as children or adolescents. The consistency of back-calculation and cohort data in haemophiliacs supports the use of back-calculation to estimate prevalence in other populations.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - epidemiology
KW  - haemophilia
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - incidence
KW  - infection
KW  - statistical analysis
KW  - America
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - hemophilia
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - statistical methods
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004031&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phylogenetic evidence for the improved RNA higher-order structure in internal ribosome entry sequences of HCV and pestiviruses.
AU  - Le ShuYun
AU  - Liu WeiMin
AU  - Maizel, J. V., Jr.
JO  - Virus Genes
JF  - Virus Genes
Y1  - 1998///
VL  - 17
IS  - 3
SP  - 279
EP  - 295
SN  - 0920-8569
AD  - Le ShuYun: Laboratory of Experimental and Computational Biology Division of Basic Sciences National Cancer Institute, N1H, Bldg 469, Room 151, Frederick, MD 21702, USA.
N1  - Accession Number: 19992201678.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 63231-63-0.  Subject Subsets: Veterinary Science; Veterinary Science
N2  - The genetic relationship of the 5′ untranslated region (UTR) and internal ribosome entry sequence (IRES) between hepatitis C virus (HCV) and animal pestiviruses was analysed. Phylogenetic analysis and RNA folding indicate a common RNA structure of the UTR of HCV and the animal pestiviruses, including HCV types 1-11, bovine diarrhea virus, border disease virus and swine fever virus. Although the common RNA structure shares similar features to that proposed for the IRES of picornavirus, phylogenetic evidence suggests 4 new tertiary interactions between conserved terminal hairpin loops and between the terminal hairpin loop of F2b and the short coding sequence for HCV and pestiviruses. It is suggested that the higher-order structures of IRES cis-acting elements for HCV and animal pestivirus are composed of stem-loop structures B-C, domains E-H, stem-loop structure J and 4 additional tertiary interactions. The common structure of IRES elements for these viruses forms a compact structure by these tertiary interactions and stem stacking. The active structural core is centred in the junction domain of E-H that is also conserved in all members of picornaviruses. The model suggests that the requirement for a small segment of the 5′ coding sequence is to form the distinct tertiary structure that facilitates the cis-acting function of the HCV IRES in the internal initiation of the translational control.
KW  - phylogenetics
KW  - RNA
KW  - structure
KW  - translation
KW  - viral diseases
KW  - hepatitis C virus
KW  - Pestivirus
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Pestivirus
KW  - Bovine diarrhea virus
KW  - Bovine diarrhoea virus
KW  - internal ribosome entry sequence
KW  - ribonucleic acid
KW  - RNA translation
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992201678&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The immunogenicity of Haemophilus influenzae type b conjugate vaccines in children born to human immunodeficiency virus-infected women.
AU  - Read, J. S.
AU  - Frasch, C. E.
AU  - Rich, K.
AU  - Fitzgerald, G. A.
AU  - Clemens, J. D.
AU  - Pitt, J.
AU  - Pelton, S. I.
AU  - Hanson, I. C.
AU  - Handelsman, E.
AU  - Diaz, C.
AU  - Fowler, M. G.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1998///
VL  - 17
IS  - 5
SP  - 391
EP  - 397
SN  - 0891-3668
AD  - Read, J. S.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA.
N1  - Accession Number: 19982012206.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Public Health
N2  - Among 227 children (35 HIV-infected, 192 uninfected) at the 9-month study visit who were known to have received age-appropriate immunization with CRM197 mutant Corynebacterium diphtheriae protein-conjugated Hib vaccine, geometric mean antibody concentrations were lower among HIV-infected children (1.64 µg/ml) than among uninfected children (2.70 µg/ml), although the difference was not statistically significant. Anti-polyribosylribitol (PRP) antibody concentrations did not vary significantly among these HIV-infected children with predominantly mild-moderate disease progression according to clinical category, immunological stage or viral load (P≥0.48). The proportion of children with antibody concentrations ≥1.0 µg/ml did not vary significantly according to HIV infection status (73% uninfected, 74% infected) or, if infected, clinical or immunological disease progression or viral load. Similar results were obtained among 127 children (17 HIV-infected, 110 uninfected) eligible for analysis at the 24-month study visit. Changes in antibody concentrations over time (between 9 and 24 months of age) did not differ significantly among 10 HIV-infected as compared with 72 uninfected children (P=0.81). These results suggest that HIV-infected children with predominantly mild-moderate disease progression respond reasonably well in terms of a quantitative antibody response to Hib conjugate vaccines during the first 2 years of life. Research to further characterize the immune response to Hib conjugate vaccines and to further delineate the "durability" of anti-PRP antibody concentrations beyond 2 years of life should be pursued.
KW  - antibodies
KW  - children
KW  - conjugate vaccines
KW  - disease course
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunization
KW  - infants
KW  - transmission
KW  - vaccines
KW  - viral load
KW  - women
KW  - Corynebacterium
KW  - Haemophilus
KW  - Haemophilus influenzae
KW  - Haemophilus influenzae type b
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Corynebacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Haemophilus
KW  - Haemophilus influenzae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogenicity
KW  - immunological reactions
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012206&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relationship between unsupplemented vitamin A serum concentrations and measles vaccine response in Jamaican children.
AU  - Willy, M. E.
AU  - Hoover, D. R.
AU  - Halsey, N. A.
AU  - Maloney, E. M.
AU  - Pate, E. J.
AU  - Wiktor, S. Z.
AU  - Blattner, W. A.
AU  - Manns, A.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1998///
VL  - 17
IS  - 6
SP  - 526
EP  - 528
SN  - 0891-3668
AD  - Willy, M. E.: Hospital Epidemiology Service, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19982013321.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition; Tropical Diseases
N2  - A total of 208 children, recruited from a larger prospective study of human T cell lymphotrophic virus type I (HTLV-I) infection among Jamaican mothers and infants, were included in the analysis [date not given]. 21 were HTLV-I seropositive. 127 (61%) of the 208 children had vitamin A serum concentrations &lt;1.05 µmol/litre and 43 (21%) had sub-clinical vitamin A deficiency (serum concentration &lt;0.70 µmol/litre). Mean vitamin A serum concentrations were similar for male and female children (0.92 and 0.97 µmol/litre, respectively). Median age of measles vaccination was 9.6 months of age. 11 of 208 children (5%) were seronegative after vaccination. There was no association between an altered measles vaccination response and HTLV-I seropositivity. The relative risk for being measles antibody-seronegative after measles vaccination for children with vitamin A serum concentrations ≤1.05 vs. &gt;1.05 µmol/litre was 1.1 (95% confidence interval, 0.3-3.7). Vitamin A serum concentration and postvaccination values obtained from an ELISA specific for measles IgG were not correlated. It is concluded that vitamin A serum concentrations do not affect the immune response to measles vaccination when children are vaccinated at 9 months and are not receiving vitamin A supplementation.
KW  - children
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - infants
KW  - retinol
KW  - vaccination
KW  - vaccines
KW  - Jamaica
KW  - man
KW  - measles virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Morbillivirus
KW  - Paramyxovirinae
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - axerophthol
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013321&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for bloodstream infections at a cancer center.
AU  - Velasco, E.
AU  - Thuler, L. C. S.
AU  - Martins, C. A. S.
AU  - Dias, L. M. C.
AU  - Gonçalves, V. M. S.
JO  - European Journal of Clinical Microbiology & Infectious Diseases
JF  - European Journal of Clinical Microbiology & Infectious Diseases
Y1  - 1998///
VL  - 17
IS  - 8
SP  - 587
EP  - 590
SN  - 0934-9723
AD  - Velasco, E.: Infectious Disease Service and Hospital Infection Control, National Cancer Institute, Cancer Hospital, Rio de Janeiro, Praça Cruz Vermelha, 23 Centro, Cep: 20 130-130, Brazil.
N1  - Accession Number: 19992001603.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Tropical Diseases
N2  - A hospital-based matched case-control study was conducted an the National Cancer Centre, Rio de Janeiro, Brazil, in order to identify risk factors for the development of bloodstream infections in adult hospitalized patients. Between January 1993 and December 1994, 264 episodes of bloodstream infection were evaluated. Significant variables identified by univariate analysis were included in a multivariate model that showed that central venous catheter (odds ratio (OR), 6.71), poor performance status (OR, 3.40), weight loss (OR, 2.47), haematological diseases (OR, 2.24), and previous antimicrobial therapy (OR, 2.12) independently influenced the outcome. The knowledge of modifiable risk factors is useful in the development of strategies that may contribute to the prevention of bloodstream infections.
KW  - aplastic anaemia
KW  - bacteraemia
KW  - catheters
KW  - immunocompromised hosts
KW  - leukaemia
KW  - lymphoma
KW  - myeloma
KW  - neoplasms
KW  - nosocomial infections
KW  - risk factors
KW  - weight losses
KW  - Brazil
KW  - Rio de Janeiro
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Brazil
KW  - aplastic anemia
KW  - bacteremia
KW  - blood cancer
KW  - cancers
KW  - hospital infections
KW  - leucaemia
KW  - leukemia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001603&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk.
AU  - Mofenson, L. M.
AU  - Yogev, R.
AU  - Korelitz, J.
AU  - Bethel, J.
AU  - Krasinski, K.
AU  - Moye, J., Jr.
AU  - Nugent, R.
AU  - Rigau-Perez, J. G.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1998///
VL  - 17
IS  - 10
SP  - 872
EP  - 880
SN  - 0891-3668
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA.
N1  - Accession Number: 19992000959.  Publication Type: Journal Article.  Corporate Author: USA, National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group Language: English.  Number of References: 28 ref. Registry Number: 308067-57-4.  Subject Subsets: Public Health
N2  - To describe the epidemiological, clinical, radiological, laboratory and treatment characteristics of acute pneumonia and its association with mortality in HIV-infected children, data were collected from 376 such children who took part in a trial of intravenous immunoglobulin (IVIG) for infection prophylaxis. The trial took place in the USA and Puerto Rico during 1988-91. CD4+ percentage was measured and HIV RNA was assessed on stored sera collected at baseline and every 3 months. Mortality was recorded during the trial and updated to 1996. All reported physician-diagnosed pneumonia episodes underwent blinded review for trial endpoint classification as acute (new radiological findings and presence of clinical symptoms) or non-acute. On blinded clinical trial endpoint review of all reported pneumonia episodes (n=281), only 47% were classified as acute. 131 episodes of acute pneumonia were reported in 93 children (47 in 31 IVIG and 84 in 62 placebo patients, P&lt;0.01). The incidence of acute pneumonia was 24 episodes per 100 patient years. Findings associated with an acute bacterial process were uncommon (leukocytosis ≥15 000/mm³ in 21% and fever ≥103°F in 32% of episodes). Multiple acute episodes occurred in 34% of the children and were associated with increased risk of mortality in a univariate analysis (risk ratio, 2.1; 95% confidence interval, 1.3-3.4, P=0.002), but in a multivariate model only baseline HIV RNA copy number and CD4+ percentage remained independently associated with mortality (relative risk, 2.0 and 1.4, respectively, P&lt;0.001). It is concluded that acute pneumonia was a common occurrence in HIV-infected children and was associated with long term mortality risk. It is suggested that multiple episodes of acute pneumonia represent a marker of progressive disease and immunological dysfunction rather than being causally associated with increased long term mortality.
KW  - acute infections
KW  - characteristics
KW  - children
KW  - clinical aspects
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunoglobulins
KW  - mortality
KW  - pneumonia
KW  - prognosis
KW  - prophylaxis
KW  - viral diseases
KW  - Puerto Rico
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Latin America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - clinical picture
KW  - death rate
KW  - gamma-globulins
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune globulins
KW  - Porto Rico
KW  - severe infections
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000959&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.
AU  - Esposito, D.
AU  - Craigie, R.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998///
VL  - 17
IS  - 19
SP  - 5832
EP  - 5843
SN  - 0261-4189
AD  - Esposito, D.: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, 5 Center Drive MSC0560, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014273.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 9007-49-2. 
N2  - The results highlight the involvement of the disordered loop of the integrase core domain, specifically residues Q148 and Y143, in binding to the terminal portion of the viral DNA ends. In addition, positions upstream in the LTR termini were identified which interact with the C-terminal domain of integrase, providing evidence for the role of that domain in stabilization of viral DNA binding. Finally, a region centred 12 bases from the viral DNA terminus was identified which appears essential for viral end DNA binding in the presence of magnesium, but not in the presence of manganese, suggesting a differential effect of divalent cations on sequence-specific binding. These results help to define important regions of contact between integrase and viral DNA, and assist in the formulation of a molecular model of this vital interaction.
KW  - binding
KW  - DNA
KW  - enzymes
KW  - human diseases
KW  - integration
KW  - interactions
KW  - proteins
KW  - structure
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014273&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Statistical issues for HIV surrogate endpoints: point/counterpoint. An NIAID workshop.
AU  - Albert, J. M.
AU  - Ioannidis, J. P. A.
AU  - Reichelderfer, P.
AU  - Conway, B.
AU  - Coombs, R. W.
AU  - Crane, L.
AU  - Demasi, R.
AU  - Dixon, D. O.
AU  - Flandre, P.
AU  - Hughes, M. D.
AU  - Kalish, L. A.
AU  - Larntz, K.
AU  - Lin DanYu
AU  - Marschner, I. C.
AU  - Muñoz, A.
AU  - Murray, J.
AU  - Neaton, J.
AU  - Pettinelli, C.
AU  - Rida, W.
AU  - Taylor, J. M. G.
AU  - Welles, S. L.
JO  - Statistics in Medicine
JF  - Statistics in Medicine
Y1  - 1998///
VL  - 17
IS  - 21
SP  - 2435
EP  - 2462
SN  - 0277-6715
AD  - Albert, J. M.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892-7620, USA.
N1  - Accession Number: 19982014573.  Publication Type: Journal Article.  Language: English.  Registry Number: 63231-63-0. 
KW  - acquired immune deficiency syndrome
KW  - CD4+ lymphocytes
KW  - disease course
KW  - disease markers
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - leukocyte count
KW  - RNA
KW  - statistical analysis
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD4+ cells
KW  - cell count
KW  - chemotherapy
KW  - disease progression
KW  - human immunodeficiency virus
KW  - ribonucleic acid
KW  - statistical methods
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Longitudinal HIV-1 RNA levels in a cohort of homosexual men.
AU  - O'Brien, T. R.
AU  - Rosenberg, P. S.
AU  - Yellin, F.
AU  - Goedert, J. J.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1998///
VL  - 18
IS  - 2
SP  - 155
EP  - 161
AD  - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, EPN 434, 6130 Executive Boulevard, Rockville, MD 20852, USA.
N1  - Accession Number: 19982009710.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 63231-63-0. 
N2  - Reverse transcriptase polymerase chain reaction (RT-PCR) was used to examine changes in serum HIV-1 RNA levels in 111 HIV-1-infected homosexual men during the period from 1982 to 1992 and their relation to clinical outcomes. HIV-1 RNA levels increased by a median of 0.08 log10 copies/ml/year (P = 0.0001). HIV-1 RNA levels rose either gradually or abruptly for the majority of subjects; 41% had no increase. Among subjects surviving at least 8 years, HIV-1 RNA was stable during the first 4 years after seroconversion (median, 0.00 log10 copies/ml/year), but rose in years 5 through 8 (median, 0.06 log10 copies /ml/year; P =0.04). The annual HIV-1 RNA level was more predictive of AIDS (relative hazard [RH], 1.75 per 0.5 log difference; 95% CI 1.38-2.21; likelihood ratio [LR], 26.2) than the initial level alone (RH, 1.39; 95% CI, 1.10-1.76; LR, 8.5). It is concluded that most HIV-1-infected persons lack a long-term viral setpoint and that failure to account for evolution of the viral level can lead to underestimation of the risk of progression.
KW  - acquired immune deficiency syndrome
KW  - disease course
KW  - homosexuality
KW  - human diseases
KW  - men
KW  - RNA
KW  - survival
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - disease progression
KW  - homosexuals
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009710&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.
AU  - Kharroubi, A. el
AU  - Piras, G.
AU  - Zensen, R.
AU  - Martin, M. A.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1998///
VL  - 18
IS  - 5
SP  - 2535
EP  - 2544
SN  - 0270-7306
AD  - Kharroubi, A. el: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19982008288.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9007-49-2. 
N2  - The regulation of HIV-1 gene expression involves a complex interplay between cellular transcription factors, chromatin-associated proviral DNA, and the virus-encoded transactivator protein, Tat. This study shows that Tat transactivates the integrated HIV-1 long terminal repeat (LTR), even in the absence of detectable basal promoter activity, and this transcriptional activation is accompanied by chromatin remodelling downstream of the transcription initiation site, as monitored by increased accessibility to restriction endonucleases. However, with an integrated promoter lacking both Sp1 and NF-κB sites, Tat was unable to either activate transcription or induce changes in chromatin structure even when it was tethered to the HIV-1 core promoter upstream of the TATA box. Tat responsiveness was observed only when Sp1 or NF-κB was bound to the promoter, implying that Tat functions subsequent to the formation of a specific transcription initiation complex. Unlike Tat, NF-κB failed to stimulate the integrated transcriptionally silent HIV-1 promoter. Histone acetylation renders the inactive HIV-1 LTR responsive to NF-κB, indicating that a suppressive chromatin structure must be remodelled prior to transcriptional activation by NF-κB. Taken together, these results suggest that Sp1 and NF-κB are required for the assembly of transcriptional complexes on the integrated viral promoter exhibiting a continuum of basal activities, all of which are fully responsive to Tat.
KW  - DNA
KW  - gene expression
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - promoters
KW  - structure
KW  - transactivation
KW  - transcription
KW  - transcription factors
KW  - Human immunodeficiency virus 1
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - nuclear factor kappaB
KW  - nuclear factors
KW  - promoter region
KW  - promoter sequences
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008288&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Modern drug development from traditional medicinal plants using radioligand receptor-binding assays.
AU  - Renuka Misra
JO  - Medicinal Research Reviews
JF  - Medicinal Research Reviews
Y1  - 1998///
VL  - 18
IS  - 6
SP  - 383
EP  - 402
SN  - 0198-6325
AD  - Renuka Misra: National Institute on Aging, National Institutes of Health, Gerontology Research Center, Nathan Shock Drive, Baltimore, MD 21224 and Xechem, Inc., Research Laboratories, 100 Jersey Avenue, Bldg. B, Suite 310, New Brunswick, NJ 08901-3279, USA.
N1  - Accession Number: 19990308273.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 37 ref. Registry Number: 9000-81-1, 9001-66-5, 9012-78-6, 56-12-2, 9011-97-6.  Subject Subsets: Horticultural Science
N2  - A number of traditionally used plant extracts and various "Ayurvedic medicines" that are highly valued in Ayurveda for antiaging, memory-enhancing, nerve tonic, anxiolytic, antiinflammatory and immunopotentiation, were screened using the National Institutes of Mental Health (NIMH) Synthetic Screening Program for scientific validation and the development of new leads of psychotherapeutic compounds using Radioligand Receptor Binding Assays (RRA). Crude methanolic extracts of plants are screened using approximately 40 different in vitro RRA (primarily from rat brain homogenates) and 6 enzyme assays including acetylcholine esterase, choline acetyltransferase, and monoamine oxidase (MAO), A and B. The total crude extracts of many of these plants showed potent selectivity to various receptors, especially γ-aminobutyric acid (GABAA), N-methyl-D-aspartic Acid (NMDA), and MAO receptors, which are presumed to be involved in mental disorders. The focus was on plants showing the highest displacement of GABA, cholecystokinin [pancreozymin] (CCK), NMDA, MAO, and benzodiazepines. Bioassay-guided fractionation of the most active extracts resulted in pure compounds which retained the original activity of the crude extract validating the folkloric use. A bioactivity-guided fractionation of Terminalia bellerica [T. bellirica] fruit extract led to the isolation of several pure compounds which retained the original activity of the crude extract for CCK and GABA receptors, with the exception of compound B3EA-6, which exhibited high affinity for neurokinin receptor (substance K ~ NK-1). The absolute structure of B3EA-6 has been established by X-ray crystallography.
KW  - acetylcholinesterase
KW  - amine oxidase (flavin-containing)
KW  - bioassays
KW  - brain
KW  - choline acetyltransferase
KW  - drugs
KW  - enzymes
KW  - esterases
KW  - gamma-aminobutyric acid
KW  - in vitro
KW  - medicinal plants
KW  - mental disorders
KW  - natural products
KW  - oxidoreductases
KW  - pancreozymin
KW  - plant extracts
KW  - receptors
KW  - screening
KW  - traditional medicines
KW  - India
KW  - rats
KW  - Terminalia bellirica
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Terminalia
KW  - Combretaceae
KW  - Myrtales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - cerebrum
KW  - cholecystokinin
KW  - drug plants
KW  - GABA
KW  - medicinal herbs
KW  - medicines
KW  - mental illness
KW  - monoamine oxidase
KW  - officinal plants
KW  - pharmaceuticals
KW  - psychiatric disorders
KW  - redox enzymes
KW  - screening tests
KW  - Plant Composition (FF040) 
KW  - Non-wood Forest Products (KK540) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Agroforestry and Multipurpose Trees; Community, Farm and Social Forestry (KK600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990308273&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb.
AU  - Neuveut, C.
AU  - Low, K. G.
AU  - Maldarelli, F.
AU  - Schmitt, I.
AU  - Majone, F.
AU  - Grassmann, R.
AU  - Jeang KuanTeh
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1998///
VL  - 18
IS  - 6
SP  - 3620
EP  - 3632
SN  - 0270-7306
AD  - Neuveut, C.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bldg 4, No. 302, 900 Rockville Pike, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19982008467.  Publication Type: Journal Article.  Language: English.  Number of References: 90 ref.
N2  - Taken together, the findings of this study suggest that Tax might activate cyclin D-cdk in a way that is separate from its ability to complex with p16INK4a. It is proposed that Tax has two effects: inactivation of a CDK inhibitor (i.e. p16INK4a) and activation of cyclin D-cdk through a CKI-independent route(s).
KW  - cell cycle
KW  - cyclins
KW  - human diseases
KW  - pathogenesis
KW  - T lymphocytes
KW  - Tax protein
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008467&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-γ) promoter and subsequent downregulation of IFN-γ production.
AU  - Mikovits, J. A.
AU  - Young, H. A.
AU  - Vertino, P.
AU  - Issa, J. P. J.
AU  - Pitha, P. M.
AU  - Turcoski-Corrales, S.
AU  - Taub, D. D.
AU  - Petrow, C. L.
AU  - Baylin, S. B.
AU  - Ruscetti, F. W.
JO  - Molecular and Cellular Biology
JF  - Molecular and Cellular Biology
Y1  - 1998///
VL  - 18
IS  - 9
SP  - 5166
EP  - 5177
SN  - 0270-7306
AD  - Mikovits, J. A.: PO Box B, Bldg. 567, Rm 253, National Cancer Institute-Frederick Cancer Research and Development Center, Frederic, MD 21702-1201, USA.
N1  - Accession Number: 19982013174.  Publication Type: Journal Article.  Language: English.  Number of References: 87 ref. Registry Number: 9007-49-2, 9008-11-1, 308079-78-9. 
N2  - This study shows that acute infection of cells with HIV-1 results in (i) increased DNA methyltransferase expression and activity, (ii) an overall increase in methylation of DNA in infected cells, and (iii) the de novo methylation of a CpG dinucleotide in the IFN-γ gene promoter, resulting in the subsequent downregulation of expression of this cytokine. The introduction of an antisense methyltransferase construct into lymphoid cells resulted in markedly decreased methyltransferase expression, hypomethylation throughout the IFN-γ gene, and increased IFN-γ production, demonstrating a direct link between methyl-transferase and IFN-γ gene expression. The ability of increased DNA methyltransferase activity to downregulate the expression of genes like the IFN-γ gene may be one of the mechanisms for dysfunction of T cells in HIV-1-infected individuals.
KW  - acute infections
KW  - cytokines
KW  - DNA
KW  - gene expression
KW  - genes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - interferon
KW  - messenger RNA
KW  - methylation
KW  - pathogenesis
KW  - pathogens
KW  - promoters
KW  - T lymphocytes
KW  - tumour necrosis factor
KW  - viral diseases
KW  - Human immunodeficiency virus 1
KW  - Retroviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - cachectin
KW  - cachexin
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - mRNA
KW  - promoter region
KW  - promoter sequences
KW  - severe infections
KW  - T cells
KW  - tumor necrosis factor
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013174&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diagnosis of invasive fungal infections: advances in nonculture systems.
AU  - Walsh, T. J.
AU  - Chanock, S. J.
JO  - Current Clinical Topics in Infectious Diseases
JF  - Current Clinical Topics in Infectious Diseases
Y1  - 1998///
VL  - 18
SP  - 101
EP  - 153
AD  - Walsh, T. J.: Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19991200083.  Publication Type: Journal Article.  Language: English.  Number of References: 277 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The current state of conventional methodologies is reviewed and the current status and future potential of non-culture methods are discussed, highlighting both their technical and clinical implications. The diagnosis of infections caused by Candida spp., Cryptococcus neoformans, Trichosporon spp., agents of endemic mycoses, Aspergillus spp., agents of zygomycosis, Fusarium spp. and Pseudallescheria boydii is considered.
KW  - aspergillosis
KW  - candidosis
KW  - cryptococcosis
KW  - diagnosis
KW  - human diseases
KW  - mycoses
KW  - reviews
KW  - zygomycosis
KW  - Aspergillus
KW  - Cryptococcus neoformans
KW  - Fusarium
KW  - man
KW  - Pseudallescheria boydii
KW  - Trichosporon
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporonaceae
KW  - candidiasis
KW  - european blastomycosis
KW  - fungus
KW  - Hyphomycetes
KW  - phycomycosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200083&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A preliminary study of factors associated with psychological adjustment and disease course in school-age children infected with the human imunodeficiency virus.
AU  - Moss, H.
AU  - Bose, S.
AU  - Wolters, P.
AU  - Brouwers, P.
JO  - Journal of Developmental and Behavioral Pediatrics
JF  - Journal of Developmental and Behavioral Pediatrics
Y1  - 1998///
VL  - 19
IS  - 1
SP  - 18
EP  - 25
SN  - 0196-206X
AD  - Moss, H.: HIV/AIDS Malignancy Branch, National Cancer Institute, Bldg 10, 13N240, Bethesda, MD 20892-1928, USA.
N1  - Accession Number: 19982004281.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
N2  - This study consisted of a longitudinal examination (baseline and approximately 2-yr follow-up) of factors associated with psychological adjustment in a sample of 24 school-age children infected with HIV. Measures of depression, anxiety, and self-concept were administered to the children, and measures of behavioural problems, social functioning, and negative life events were administered to the parents. Generally, psychological adjustment seemed stable, though a decrease in positive social self-concept over time was observed. Negative life events were significantly associated with greater adverse psychological and behavioural outcomes at both baseline and follow-up. An additional component to the study investigated factors associated with survival. Examination of an additional 5 children who died within 12 months of baseline indicated that they experienced significantly more adverse life events, were less resilient, and had greater disease progression. The sample size was small and requires that these findings be considered as preliminary and suggestive rather than conclusive.
KW  - children
KW  - disease course
KW  - follow up
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - psychosocial aspects
KW  - survival
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004281&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infant feeding and risk of mother-to-child transmission of HIV-1 in São Paulo State, Brazil.
AU  - Tess, B. H.
AU  - Rodrigues, L. C.
AU  - Newell, M. L.
AU  - Dunn, D. T.
AU  - Lago, T. D. G.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1998///
VL  - 19
IS  - 2
SP  - 189
EP  - 194
AD  - Tess, B. H.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6130 Executive Boulevard, EPN/434, Rockville, MD 20852, USA.
N1  - Accession Number: 19982014118.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Human Nutrition; Dairy Science
KW  - breast feeding
KW  - epidemiology
KW  - human diseases
KW  - human milk
KW  - infant feeding
KW  - infants
KW  - maternal transmission
KW  - risk factors
KW  - Brazil
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - breast milk
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Milk and Dairy Produce (QQ010) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preventing discrimination against volunteers in prophylactic HIV vaccine trials: lessons from a phase II trial.
AU  - Sheon, A. R.
AU  - Wagner, L.
AU  - McElrath, M. J.
AU  - Keefer, M. C.
AU  - Zimmerman, E.
AU  - Israel, H.
AU  - Berger, D.
AU  - Fast, P.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1998///
VL  - 19
IS  - 5
SP  - 519
EP  - 526
AD  - Sheon, A. R.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
N1  - Accession Number: 19992004144.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
N2  - Frequency of HIV testing and discrimination among participants in a preventive phase II HIV vaccine trial in the USA are described. 266 vaccine trial volunteers were eligible; 247 participated in a confidential survey. 63 volunteers (26% of respondents) reported 185 HIV tests during the prior 12 to 24 months; most tests were for other research studies, health care, insurance, incarceration, or employment. Only 5 volunteers reported having positive HIV test results. Volunteers reported 99 adverse social incidents or problems, 53 of which were related to the trial. The most common type of event occurred when volunteers disclosed their trial participation and were mistakenly presumed to be infected with HIV. Few reported difficulty obtaining insurance, job loss, and inadvertent disclosure of their participation in the trial. In this vaccine trial, few serious social harms were reported. It is concluded that those who conduct HIV tests for insurance, employment, health care, or other reasons should be made aware that HIV vaccines can cause false-positive HIV test results. Those planning future trials must continue to provide needed support to volunteers. Social harms should be monitored with the same vigilance accorded to physical harms.
KW  - clinical trials
KW  - discrimination
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - surveys
KW  - vaccines
KW  - volunteers
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet.
AU  - Snyderwine, E. G.
AU  - Davis, C. D.
AU  - Schut, H. A. J.
AU  - Roberts-Thomson, S. J.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1998///
VL  - 19
IS  - 7
SP  - 1209
EP  - 1215
SN  - 0143-3334
AD  - Snyderwine, E. G.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Building 37, Room 3C28, NIH, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19981418176.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 9007-49-2.  Subject Subsets: Human Nutrition
N2  - A carcinogenic dose-regimen of oral amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (75 mg/kg, 10 doses, once per day) was administered to 43-day old female Sprague-Dawley rats. The rats were then placed on a defined high fat (23.5% corn [maize] oil) or low fat (5% corn oil) diet for up to 6 weeks. The percentage of proliferating cells in terminal end bud (TEB) epithelial structures of the rat mammary gland was examined by proliferating cell nuclear antigen staining, mammary gland architecture by whole mounting, and PhIP-DNA adduct levels in mammary epithelial cells by the 32P-post-labelling assay. Immediately after dosing, the percentage of proliferating epithelial cells in TEBs was significantly higher in PhIP-treated than control rats receiving vehicle only (7.5±0.9% (n=99) vs. 4.2±0.6% (n=127), respectively). The mammary glands of PhIP-treated rats showed a significantly lower density of alveolar buds (ABs) and a higher density of TEBs than control rats, which suggests that PhIP exposure partially inhibited the normal glandular differentiation of TEBs to ABs. After 6 weeks on the diet, proliferation in TEBs was higher in rats given PhIP plus a high fat diet than in rats given vehicle plus a low fat diet. The mammary glands from rats on a high fat diet also showed a higher density of TEBs than those from rats on a low fat diet (2.08±0.34% vs. 1.04±0.20%, respectively (n=6)). PhIP-DNA adduct levels were relatively high in mammary epithelial cells of treated rats. At 3 h after the last dose of PhIP, DNA adduct levels (relative adduct labelling (RAL) × 107) were 10.5±1.7 (n=8) and 0.9±0.2 (n=7) in epithelial cells isolated from mammary gland and in the liver, respectively. DNA adduct removal rates from the mammary gland were not different between rats on the high fat and low fat diets. Adducts were still detected after 6 weeks on either diet. Thus, events that occurred prior to neoplasia in the mammary glands of PhIP-treated rats include formation of PhIP-DNA adducts at relatively high levels, and enhanced proliferation in TEBs (putative sites of origin of mammary gland carcinomas) and partial inhibition of TEB differentiation. The high fat diet, a promoter of PhIP-induced mammary gland carcinogenesis, appeared to sustain the proliferative effect of PhIP in mammary gland TEBs at a time when PhIP-DNA adducts are still detectable.
KW  - carcinogenesis
KW  - carcinogens
KW  - cell division
KW  - DNA
KW  - epithelium
KW  - fat
KW  - liver
KW  - maize oil
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - corn oil
KW  - deoxyribonucleic acid
KW  - karyokinesis
KW  - mammary tumour
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418176&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Public health in central and eastern Europe and the role of environmental pollution.
AU  - Little, R. E.
JO  - Annual Review of Public Health
JF  - Annual Review of Public Health
Y1  - 1998///
VL  - 19
SP  - 153
EP  - 172
SN  - 0163-7525
AD  - Little, R. E.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27514, USA.
N1  - Accession Number: 19992001744.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
N2  - The central and eastern European countries that composed the former Eastern Bloc have experienced an alarming decline in public health since the dissolution of the Soviet Union. Death rates have increased in most age groups. Life expectancy, especially among males, has decreased in many countries; in Russia, male life expectancy dropped by 6 years between 1989 and 1994. By 2020, these countries are projected to have smaller increases in life expectancy than any other geographical region. The conditions responsible for the excess mortality are cardiovascular disease, cancer, and injuries among adults. The major factors in the sharp increase are poverty, social disintegration, and crime, overlaid on historically high rates of smoking, alcohol use, and psychosocial stress. Environmental pollution, although common and sometimes severe in the former Eastern Bloc is another cause of the sharp decline in public health since 1989.
KW  - cardiovascular diseases
KW  - human diseases
KW  - morbidity
KW  - mortality
KW  - neoplasms
KW  - pollution
KW  - public health
KW  - trauma
KW  - Central Europe
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Europe
KW  - cancers
KW  - death rate
KW  - environmental pollution
KW  - traumas
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001744&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.
AU  - Lauro, D.
AU  - Kido, Y.
AU  - Castle, A. L.
AU  - Zarnowski, M. J.
AU  - Hayashi, H.
AU  - Ebina, Y.
AU  - Accili, D.
JO  - Nature Genetics
JF  - Nature Genetics
Y1  - 1998///
VL  - 20
IS  - 3
SP  - 294
EP  - 298
SN  - 1061-4036
AD  - Lauro, D.: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19990106730.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition; Animal Breeding
N2  - Transgenic mice were generated which were insulin-resistant in skeletal muscle and adipose tissue. The mice developed all the prodromal features of type 2 diabetes but, despite the compounded effect of peripheral insulin resistance and a mild impairment of β cell function, failed to become diabetic. It is suggested that the primary site(s) of insulin resistance in diabetes needs to be re-examined.
KW  - adipose tissue
KW  - animal models
KW  - diabetes
KW  - genetically engineered organisms
KW  - glucose tolerance
KW  - insulin
KW  - liver
KW  - receptors
KW  - skeletal muscle
KW  - transgenic animals
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood sugar tolerance
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GEOs
KW  - GMOs
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Animal Models of Human Nutrition (VV140) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990106730&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP119) and their role in immunity to malaria.
AU  - Tian JingHui
AU  - Good, M. F.
AU  - Chakrit Hirunpetcharat
AU  - Sanjai Kumar
AU  - Ling, I. T.
AU  - Jackson, D.
AU  - Cooper, J.
AU  - Lukszo, J.
AU  - Coligan, J.
AU  - Ahlers, J.
AU  - Saul, A.
AU  - Berzofsky, J. A.
AU  - Holder, A. A.
AU  - Miller, L. H.
AU  - Kaslow, D. C.
JO  - Parasite Immunology
JF  - Parasite Immunology
Y1  - 1998///
VL  - 20
IS  - 6
SP  - 263
EP  - 278
SN  - 0141-9838
AD  - Tian JingHui: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980808687.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Protozoology
N2  - To determine whether MSP119-specific effector T cells can control parasitaemia, the specificity of T cells induced following immunization of mice with recombinant forms of Plasmodium yoelii MSP119 was analysed. There was no evidence that effector T cells were capable of protection since: immunization of mice with yeast-expressed MSP119, but not defined epitopes, was able to induce protection, and long-term MSP119-specific CD4+ T cell lines were incapable of adoptively transferring protection. In contrast, priming mice with the T cell epitopes resulted in a rapid anamnestic antibody response to MSP119 after either challenge with MSP119 or parasite. It is concluded that MSP119 contains multiple T cell epitopes but such epitopes are the targets of helper T cells for antibody response but not of identified effector T cells capable of controlling parasitaemia.
KW  - antigens
KW  - epitopes
KW  - experimental infections
KW  - immune response
KW  - immunity
KW  - immunization
KW  - laboratory animals
KW  - merozoites
KW  - parasitaemia
KW  - parasites
KW  - recombinant proteins
KW  - surface proteins
KW  - T lymphocytes
KW  - mice
KW  - Plasmodium yoelii
KW  - protozoa
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - antigenic determinants
KW  - antigenicity
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - membrane proteins
KW  - merozoite surface protein 1
KW  - parasitemia
KW  - T cells
KW  - T helper cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification of anti-HIV lignans from Larrea tridentata by pH-zone-refining countercurrent chromatography.
AU  - Ma, Y.
AU  - Qi, L.
AU  - Gnabre, J. N.
AU  - Huang, R. C. C.
AU  - Chou, F. E.
AU  - Ito, Y.
JO  - Journal of Liquid Chromatography & Related Technologies
JF  - Journal of Liquid Chromatography & Related Technologies
Y1  - 1998///
VL  - 21
IS  - 1/2
SP  - 171
EP  - 181
AD  - Ma, Y.: Laboratory of Biomedical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Rm 7N322, Bldg. 10, 10 Center Drive MSC 1676, Bethesda, MD 20892-1676, USA.
N1  - Accession Number: 19980304374.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - Anti-HIV lignans were purified from a dichloromethane extract of Larrea tridentata leaves by high-speed countercurrent chromatography (CCC) using pH-zone-refining CCC. When 10-20 g of the crude extract was put onto a column filled with methyl tert-butyl ether containing 25 mM trifluoroacetic acid, and eluted stepwise with aqueous 0, 50 and 100 mM NaOH, NDGA (nordihydroguaiaretic acid) and its monomethyl esters were separated as rectangular 'peaks' associated with specific pH zones. The method was also successfully applied to synthetic lignans, resulting in resolution of NDGA and its mono- and dimethyl esters.
KW  - antiviral agents
KW  - antiviral plants
KW  - chromatography
KW  - esters
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - leaves
KW  - lignans
KW  - pH
KW  - plant extracts
KW  - purification
KW  - separation
KW  - Larrea tridentata
KW  - plants
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Larrea
KW  - Zygophyllaceae
KW  - Sapindales
KW  - Geraniales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - hydrogen ion concentration
KW  - potential of hydrogen
KW  - separating
KW  - Techniques and Methodology (ZZ900) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Plant Composition (FF040) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular alterations in sarcomas.
AU  - Goletz, T. J.
AU  - Worley, B. S.
AU  - Berzofsky, J. A.
AU  - Mackall, C. L.
AU  - Helman, L. J.
JO  - Veterinary Cancer Society Newsletter
JF  - Veterinary Cancer Society Newsletter
Y1  - 1998///
VL  - 22
IS  - 4
SP  - 9
EP  - 11
AD  - Goletz, T. J.: Pediatric Oncology Branch, Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992203383.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Veterinary Science
KW  - chromosome translocation
KW  - cytogenetics
KW  - neoplasms
KW  - sarcoma
KW  - cancers
KW  - interchange
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992203383&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine.
AU  - Childs, R.
AU  - Sanchez, C.
AU  - Engler, H.
AU  - Preuss, J.
AU  - Rosenfeld, S.
AU  - Dunbar, C.
AU  - Rhee, F. van
AU  - Plante, M.
AU  - Phang, S.
AU  - Barrett, A. J.
JO  - Bone Marrow Transplantation
JF  - Bone Marrow Transplantation
Y1  - 1998///
VL  - 22
IS  - 9
SP  - 889
EP  - 893
SN  - 0268-3369
AD  - Childs, R.: Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992000654.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Public Health
N2  - Between September 1993 and January 1997, 56 patients received a T cell-depleted, HLA-identical sibling bone marrow transplant (BMT) for haematological malignancy at a hospital in the USA. Nine of 56 (20% actuarial) developed haemorrhagic cystitis (HC) 15-368 days post BMT. Haematuria was severe and prolonged (median duration 18 days). In 8 patients (89%), a viral aetiology was confirmed (4 adenovirus, 4 polyomavirus). HC was associated with significant morbidity, with all patients requiring continuous bladder irrigation and transfusion support for blood loss and thrombocytopenia. HC occurring before day 100 was significantly associated with a reduction in long-term survival: 1/7 (14.3%) patients developing HC before day 100 became long-term survivors vs 21/49 (42.8%) without HC by day 100 (P=0.034). In univariate analysis, HC was associated with a diagnosis of multiple myeloma (P=0.02). There was a trend towards a higher incidence of HC in patients reactivating cytomegalovirus (CMV) compared with those remaining CMV negative (18.4 vs 5.5% respectively, P=0.17). HC was not associated with graft-versus-host disease, or with the transplant dose of CD34+ progenitors or CD3+ cells, patient age or sex. Life-threatening, viral-induced HC and the unusually high incidence of adenovirus-induced HC may have been caused by immune deficiency associated with T cell depletion in this series.
KW  - bone marrow transplant
KW  - clinical aspects
KW  - cystitis
KW  - haematuria
KW  - human diseases
KW  - immunocompromised hosts
KW  - immunological deficiency
KW  - infections
KW  - opportunistic infections
KW  - survival
KW  - T lymphocytes
KW  - transplant recipients
KW  - urinary tract
KW  - urinary tract infections
KW  - viral diseases
KW  - USA
KW  - human adenovirus
KW  - Human herpesvirus 5
KW  - man
KW  - Polyomavirus
KW  - Mastadenovirus
KW  - Adenoviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Polyomaviridae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - clinical picture
KW  - hematuria
KW  - human cytomegalovirus
KW  - immune deficiency
KW  - immunodeficiency
KW  - recipients
KW  - T cells
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Expression of nitric oxide synthase isoforms in normal human tracheobronchial epithelial cells in vitro: dependence on retinoic acid and the state of differentiation.
AU  - Norford, D.
AU  - Koo, J. S.
AU  - Gray, T.
AU  - Alder, K.
AU  - Nettesheim, P.
JO  - Experimental Lung Research
JF  - Experimental Lung Research
Y1  - 1998///
VL  - 24
IS  - 3
SP  - 355
EP  - 366
SN  - 0190-2148
AD  - Norford, D.: Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 19991402068.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - The retinoic acid (RA) and differentiation dependence of constitutive expression of the nitric oxide synthase (NOS) isoforms, iNOS, eNOS, and bNOS, was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in cultured, normal, human, tracheobronchial epithelial (NHTBE) cells. In the presence of RA (RA+), early passage NHTBE cells grown in air-liquid interface (ALI) cultures undergo mucous differentiation; in the absence of RA (RA-), they undergo metaplastic squamous differentiation. Under both conditions the respective differentiated phenotype develops around day 10 of culture. iNOS mRNA levels were much higher in RA+ cultures, expressing the mucous phenotype, than in RA- cultures, expressing the metaplastic squamous phenotype. In contrast, eNOS mRNA levels were much higher in RA- cultures than in RA+ cultures. Expression of bNOS was not significantly affected by the RA status. The pattern of expression of NOS isoforms was then studied during the course of development of the two cellular phenotypes. During the early stages of differentiation, expression of iNOS (RA+) and eNOS (RA-) was very low, indicating that the expression of these two isoforms was not only dependent on the presence or absence of RA, but also on the degree of differentiation. The differentiation dependence of bNOS mRNA was less obvious. Four days of RA treatment of RA- cultures, which reverses the squamous phenotype and restores mucous differentiation, induced iNOS expression in a concentration-dependent manner. eNOS expression was depressed by 10-8M RA, while bNOS mRNA levels were slightly reduced by 10-6M RA. No NOS proteins were detected in unstimulated RA+ and RA- cultures. iNOS protein was induced by cytokine treatment in RA+ cultures in contrast to iNOS and bNOS protein levels, which were unaffected. These studies show that constitutive expression of the NOS isoforms is differentially regulated and that iNOS and eNOS mRNA levels are dependent on the stage of mucous and squamous differentiation, respectively. bNOS expression was only marginally affected by the RA or differentiation status.
KW  - cell cultures
KW  - differentiation
KW  - epithelium
KW  - gene expression
KW  - lungs
KW  - retinoic acid
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - nitric oxide synthase
KW  - tretinoin
KW  - vitamin A acid
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991402068&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Why is docosahexaenoic acid essential for nervous system function?
AU  - Mitchell, D. C.
AU  - Gawrisch, K.
AU  - Litman, B. J.
AU  - Salem, N., Jr.
JO  - Biochemical Society Transactions
JF  - Biochemical Society Transactions
Y1  - 1998///
VL  - 26
IS  - 3
SP  - 365
EP  - 370
SN  - 0300-5127
AD  - Mitchell, D. C.: Laboratory of Membrane Biochemistry and Biophysics, DICBR, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, Room 158, Rockville, MD 20852. USA.
N1  - Accession Number: 19981415250.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 25167-62-8.  Subject Subsets: Human Nutrition
N2  - The essentiality of docosahexaenoic acid is discussed.
KW  - development
KW  - docosahexaenoic acid
KW  - essential fatty acids
KW  - infants
KW  - nervous system
KW  - polyenoic fatty acids
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - polyunsaturated fatty acids
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415250&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Successful medical management of isolated renal zygomycosis: case report and review.
AU  - Weng, D. E.
AU  - Wilson, W. H.
AU  - Little, R.
AU  - Walsh, T. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 26
IS  - 3
SP  - 601
EP  - 605
SN  - 1058-4838
AD  - Weng, D. E.: Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19991201550.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The medical management of isolated renal zygomycosis in 42-year-old man from the USA, with AIDS, during chemotherapy for AIDS-related lymphoma, is described. After initial presentation during the first cycle of chemotherapy, the infection was contained within the kidney following recovery of the neutrophil count without medical or surgical intervention. Cultures of tissue specimens grew Rhizopus microsporus. Since the patient was not considered to be a candidate for nephrectomy, the infection was treated with amphotericin B lipid complex during subsequent chemotherapy. Neutropenia was minimized by the addition of cytokine support therapy with granulocyte colony-stimulating factor and reduced doses of chemotherapy. Following this strategy, his lymphoma completely resolved, and renal zygomycosis was controlled. The patient remained in complete remission for 18 months without evidence of progressive fungal infection. Previously reported cases of renal zygomycosis are discussed.
KW  - acquired immune deficiency syndrome
KW  - amphotericin B
KW  - application methods
KW  - case reports
KW  - clinical aspects
KW  - cytokines
KW  - drug formulations
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - kidneys
KW  - lipids
KW  - lymphoma
KW  - men
KW  - neutropenia
KW  - opportunistic infections
KW  - prognosis
KW  - zygomycosis
KW  - USA
KW  - man
KW  - Mucoraceae
KW  - Rhizopus
KW  - Rhizopus microsporus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mucoraceae
KW  - Mucorales
KW  - Mucoromycotina
KW  - Zygomycota
KW  - fungi
KW  - Rhizopus
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - chemotherapy
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - lipins
KW  - phycomycosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201550&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Burkholderia pseudomallei infection in a Puerto Rican patient with chronic granulomatous disease: case report and review of occurrences in the Americas.
AU  - Dorman, S. E.
AU  - Gill, V. J.
AU  - Gallin, J. I.
AU  - Holland, S. M.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 26
IS  - 4
SP  - 889
EP  - 894
SN  - 1058-4838
AD  - Dorman, S. E.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19982008000.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Tropical Diseases
N2  - Burkholderia species, notably B. cepacia and B. gladioli, are important pathogens in patients with chronic granulomatous disease (CGD). B. pseudomallei, the causative agent of melioidosis, is endemic in Southeast Asia and northern Australia but is a rare pathogen in other parts of the world. The occurrence of B. pseudomallei infection in a Puerto Rican patient with CGD is described. This is one of only a small number of documented cases of melioidosis autochthonous to the Americas and is the first reported case of B. pseudomallei infection in a CGD patient from the Americas. It is concluded that B. pseudomallei, like B. cepacia and B. gladioli, should be considered a potential pathogen in patients with CGD and that melioidosis should be considered in the differential diagnosis for ill residents of or travellers to Puerto Rico.
KW  - case reports
KW  - human diseases
KW  - melioidosis
KW  - Puerto Rico
KW  - Burkholderia pseudomallei
KW  - man
KW  - Burkholderia
KW  - Burkholderiaceae
KW  - Burkholderiales
KW  - Betaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Latin America
KW  - bacterium
KW  - Berkholderia
KW  - chronic granulomatous disease
KW  - Porto Rico
KW  - Pseudomonas pseudomallei
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine.
AU  - Silva, A. E.
AU  - McMahon, B. J.
AU  - Parkinson, A. J.
AU  - Sjogren, M. H.
AU  - Hoofnagle, J. H.
AU  - Bisceglie, A. M. di
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 26
IS  - 4
SP  - 895
EP  - 897
SN  - 1058-4838
AD  - Silva, A. E.: Hepatitis Studies Section, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19982008001.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Registry Number: 9007-49-2. 
N2  - Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only 5 persons, 4 of whom remained positive during retesting. Most persons had a primary antibody response with 3 doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.
KW  - antibodies
KW  - antigens
KW  - core proteins
KW  - disease markers
KW  - DNA
KW  - hepatitis B
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - serology
KW  - vaccination
KW  - hepatitis B virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - deoxyribonucleic acid
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - AIDS-associated atypical Pneumocystis carinii pneumonia revisited.
AU  - Groll, A. H.
AU  - Keul, H. G.
AU  - Brodt, R.
AU  - Schneider, M.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 26
IS  - 4
SP  - 1005
EP  - 1006
SN  - 1058-4838
AD  - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982007170.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A retrospective review of postmortem examination results of 359 AIDS patients who died at the University Hospital, Frankfurt, Germany, during 1982-92, demonstrated P. carinii pneumonia in 78 (22%) cases. Atypical presentations were recorded in 14 cases (during 1989-92), including tissue necrosis, cavitation, honeycombing and small granuloma-like lesions were first observed in 1989, and their relative prevalence reached 40% during 1989-92. Foci of necrotizing P. carinii infection were present in lymph nodes (4 cases) and/or various parenchymatous organs (3). Clinically atypical P. carinii pneumonia was associated with very low CD4+ lymphocyte counts, spontaneous pneumothoraces, one or more prior episodes of P. carinii pneumonia, a history of other significant pulmonary complications an a high prevalence of concomitant pulmonary cytomegalovirus infection at postmortem examination. Nine of the 14 patients with atypical P. carinii pneumonia had received aerosolized pentamidine prophylaxis for a mean of 16 months before death.
KW  - acquired immune deficiency syndrome
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infections
KW  - lungs
KW  - mycoses
KW  - Pneumocystis carinii pneumonia
KW  - pneumocystosis
KW  - pneumonia
KW  - postmortem examinations
KW  - Germany
KW  - fungi
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Western Europe
KW  - Europe
KW  - AIDS
KW  - autopsy
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - postmortem inspections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.
AU  - Walsh, T. J.
AU  - Hiemenz, J. W.
AU  - Seibel, N. L.
AU  - Perfect, J. R.
AU  - Horwith, G.
AU  - Lee, L.
AU  - Silber, J. L.
AU  - DiNubile, M. J.
AU  - Reboli, A.
AU  - Bow, E.
AU  - Lister, J.
AU  - Anaissie, E. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 26
IS  - 6
SP  - 1383
EP  - 1396
SN  - 1058-4838
AD  - Walsh, T. J.: National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202288.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety and antifungal efficacy of amphotericin B lipid complex (ABLC) were evaluated in 556 cases of invasive fungal infection treated through an open-label, single-patient, emergency-use study of patients from the USA, who were refractory to or intolerant of conventional antifungal therapy. All 556 treatment episodes were evaluable for safety. During the course of ABLC therapy, serum creatinine levels significantly decreased from baseline (P&lt;0.02). Among 162 patients with serum creatinine values ≥2.5 mg/dl at the start of ABLC therapy (baseline), the mean serum creatinine value decreased significantly from the 1st week until the 6th week (P&lt;0.0003). Among the 291 mycologically confirmed cases evaluable for therapeutic response, there was a complete or partial response to ABLC in 167 (57%), including 42% (55) of 130 cases of Aspergillus infection, 67% (28) of 42 cases of disseminated Candida infection, 71% (17) of 24 cases of zygomycosis, and 82% (9) of 11 cases of Fusarium infection. Response rates varied according to the pattern of invasive fungal infection, underlying condition, and reason for enrolment (intolerance vs. progressive infection). These results support the use of ABLC in the treatment of invasive fungal infections in patients who are intolerant of or refractory to conventional antifungal therapy.
KW  - amphotericin B
KW  - antifungal agents
KW  - application methods
KW  - aspergillosis
KW  - candidosis
KW  - drug formulations
KW  - drug therapy
KW  - efficacy
KW  - fusariosis
KW  - human diseases
KW  - infections
KW  - lipids
KW  - safety
KW  - zygomycosis
KW  - USA
KW  - Aspergillus
KW  - Candida
KW  - Fusarium
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - candidiasis
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - fusarioses
KW  - Hyphomycetes
KW  - lipins
KW  - phycomycosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Flucytosine monotherapy for cryptococcosis.
AU  - Hospenthal, D. R.
AU  - Bennett, J. E.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 27
IS  - 2
SP  - 260
EP  - 264
SN  - 1058-4838
AD  - Hospenthal, D. R.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202610.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 2022-85-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - Experience with flucytosine (5-FC) monotherapy in 27 patients with disseminated Cryptococcus neoformans infection treated at the Clinical Center of the National Institutes of Health, Bethesda, USA, during 1968-73 was reviewed. Patients were selected on the basis of criteria associated with good prognosis. In this group, 5-FC monotherapy resulted in cure in 8 cases and improvement in 2. Overall, response was seen in 10 (43%) of 23 evaluable patients. Therapy failed for 13 patients, including 5 who relapsed, 2 who had partial responses and 6 without response. Resistance was noted to have developed in isolates from 6 (50%) of 12 patients for whom therapy failed. It is concluded that although the 57% failure rate associated with 5-FC alone precludes its use as monotherapy, the study did show that this treatment is well tolerated and that failure is not invariably associated with development of resistance.
KW  - antifungal agents
KW  - cryptococcosis
KW  - drug therapy
KW  - efficacy
KW  - flucytosine
KW  - generalized infections
KW  - human diseases
KW  - infections
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - 5-fluorocytosine
KW  - chemotherapy
KW  - european blastomycosis
KW  - fungistats
KW  - fungus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202610&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasive pulmonary aspergillosis in a critically ill neonate: case report and review of invasive aspergillosis during the first 3 months of life.
AU  - Groll, A. H.
AU  - Jaeger, G.
AU  - Allendorf, A.
AU  - Herrmann, G.
AU  - Schloesser, R.
AU  - Loewenich, V. von
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 27
IS  - 3
SP  - 437
EP  - 452
SN  - 1058-4838
AD  - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991201260.  Publication Type: Journal Article.  Language: English.  Number of References: 106 ref. Registry Number: 1397-89-3. 
N2  - A fatal case of invasive pulmonary Aspergillus infection is reported in a severely ill neonate from the USA and 43 additional cases of invasive aspergillosis reported during 1955-1996 that occurred during the first 3 months of life are also reviewed. 11 of the 44 patients had primary cutaneous aspergillosis, 10 had invasive pulmonary aspergillosis and 14 had disseminated disease. Most infections were nosocomial in origin. Prematurity (43%); proven chronic granulomatous disease (14%); and a complex of diarrhoea, dehydration, malnutrition and invasive bacterial infections (23%) accounted for the majority of underlying conditions. At least 41% of the patients had received corticosteroid therapy before diagnosis, but only 1 patient had been neutropenic. Among patients who received medical and/or surgical treatment, outcome was relatively favourable, with an overall survival rate of 73%. It is concluded that invasive aspergillosis may occur in neonates and young infants and warrants consideration under certain circumstances. Current therapeutic approaches consist of high-dose amphotericin B and appropriate surgical interventions.
KW  - amphotericin B
KW  - aspergillosis
KW  - bacterial diseases
KW  - case reports
KW  - diarrhoea
KW  - disseminated infections
KW  - generalized infections
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - malnutrition
KW  - neonates
KW  - nosocomial infections
KW  - opportunistic infections
KW  - predisposition
KW  - prematurity
KW  - reviews
KW  - survival
KW  - USA
KW  - Aspergillus
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - chronic granulomatous disease
KW  - diarrhea
KW  - fungus
KW  - hospital infections
KW  - Hyphomycetes
KW  - newborn infants
KW  - scouring
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201260&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Editorial response: primary cutaneous aspergillosis-an emerging infection among immunocompromised patients.
AU  - Walsh, T. J.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 27
IS  - 3
SP  - 453
EP  - 457
SN  - 1058-4838
AD  - Walsh, T. J.: Immunocompromised Host Section, Bldg. 10, Rm 13N-240, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982012377.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref.
KW  - acquired immune deficiency syndrome
KW  - aspergillosis
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - mycoses
KW  - Aspergillus
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - AIDS
KW  - fungus
KW  - human immunodeficiency virus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012377&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer.
AU  - You WeiCheng
AU  - Zhang Lian
AU  - Gail, M. H.
AU  - Ma JunLing
AU  - Chang YunSheng
AU  - Blot, W. J.
AU  - Li JiYou
AU  - Zhao CaiLin
AU  - Liu WeiDong
AU  - Li HuiQing
AU  - Hu YuanReng
AU  - Bravo, J. C.
AU  - Correa, P.
AU  - Xu GuangWei
AU  - Fraumeni, J. F., Jr.
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1998///
VL  - 27
IS  - 6
SP  - 941
EP  - 944
SN  - 0300-5771
AD  - You WeiCheng: National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992003639.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Tropical Diseases
N2  - In order to evaluate determinants of intestinal metaplasia (IM) and dysplasia (DYS) in Cangshan County, Shandong County, China, a low risk area of gastric cancer (GC), a survey was conducted among 214 adults who participated in a gastroscopic screening survey in Cangshan County in 1994. A dietary interview and measurement of serum H. pylori antibodies were performed. The prevalence of H. pylori was lowest (19%) among those with normal gastric mucosa, rising steadily to 35% for superficial gastritis (SG), 56% for chronic atrophic gastritis (CAG), 80% for IM and 100% for DYS. The prevalence odds of precancerous lesions were compared with the odds of normal histology or SG. The odds ratio (OR) or CAG associated with H. pylori positivity was 4.2 (95% confidence interval (CI): 1.7-10.0), while the OR of IM/DYS associated with H. pylori positivity was 31.5 (95% CI : 5.2-187). After adjusting for H. pylori infection, drinking alcohol was a risk factor for CAG (OR=3.2, 95% CI: 1.1-9.2) and IM/DYS (OR=7.8, 95% CI: 1.3-47.7). Consumption of garlic showed non-significant protective effects and an inverse association with H. pylori infection. It is suggested that infection with H. pylori is a risk factor and garlic may be protective in the development and progression of advanced precancerous gastric lesions in an area of China at relatively low risk of GC.
KW  - alcohol intake
KW  - bacterial diseases
KW  - diet
KW  - epidemiology
KW  - garlic
KW  - gastritis
KW  - human diseases
KW  - lesions
KW  - medicinal plants
KW  - neoplasms
KW  - risk factors
KW  - seroprevalence
KW  - stomach
KW  - stomach cancer
KW  - surveys
KW  - China
KW  - Shandong
KW  - Allium sativum
KW  - Helicobacter pylori
KW  - man
KW  - Allium
KW  - Alliaceae
KW  - Liliaceae
KW  - Liliales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Helicobacter
KW  - Helicobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - Northern China
KW  - China
KW  - alcohol consumption
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - cancers
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - People's Republic of China
KW  - Shantung
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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TY  - JOUR
T1  - Primary cutaneous Acanthamoeba infection in a patient with AIDS.
AU  - Migueles, S.
AU  - Kumar, P.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1998///
VL  - 27
IS  - 6
SP  - 1547
EP  - 1548
SN  - 1058-4838
AD  - Migueles, S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11S231, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990802330.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Subject Subsets: Protozoology
KW  - acquired immune deficiency syndrome
KW  - case reports
KW  - face
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - parasites
KW  - skin diseases
KW  - Maryland
KW  - USA
KW  - Acanthamoeba castellanii
KW  - man
KW  - protozoa
KW  - Acanthamoeba
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - dermatoses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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TY  - JOUR
T1  - Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells.
AU  - Belkaid, Y.
AU  - Butcher, B.
AU  - Sacks, D. L.
JO  - European Journal of Immunology
JF  - European Journal of Immunology
Y1  - 1998///
VL  - 28
IS  - 4
SP  - 1389
EP  - 1400
SN  - 0014-2980
AD  - Belkaid, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 20000805916.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9008-11-1, 308079-78-9.  Subject Subsets: Protozoology
N2  - Intracellular staining for cytokines and parasites, combined with 2-colour flow cytometric analyses, were used to examine the frequencies of IL-12-, TNF-α- and IL-6-producing macrophages in response to Leishmania major infection and/or activation with IFN-γ/lipopolysaccharide (LPS). Inflammatory macrophages were obtained from nonimmune granulomas, initiated by the injection of polyacrylamide microbeads (Bio-gel P-100) into subcutaneous pouches of 4 mouse strains (BALB/c, C3H/HeN, C57BL/6, CBA). Infection of inflammatory macrophages in vitro using metacyclic promastigotes produced identical effects on cytokine responses regardless of whether cells from genetically resistant or susceptible mouse strains were used: IL-12 was not produced in response to infection itself, virtually every infected cell lost its ability to produce IL-12 in response to IFN-γ/LPS, and the IL-6 response was partially inhibited, whereas the TNF-α response of infected cells was unimpaired. Low-multiplicity infection of inflammatory macrophages in vivo using either metacyclic promastigotes or tissue amastigotes also resulted in the complete and selective inhibition of IL-12 responses in infected cells. These data establish the physiologic relevance of prior observations regarding the selective impairment of IL-12 induction pathways in infected macrophages, and suggest a mechanisms for the delayed onset of cell-mediated control mechanisms that is typical of even self-limiting forms of leishmanial disease.
KW  - cytokines
KW  - experimental infections
KW  - immune response
KW  - immunological deficiency
KW  - in vitro
KW  - interferon
KW  - interleukin 12
KW  - interleukin 6
KW  - laboratory animals
KW  - lipopolysaccharides
KW  - macrophages
KW  - parasites
KW  - tumour necrosis factor
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - cachectin
KW  - cachexin
KW  - immune deficiency
KW  - immunity reactions
KW  - immunodeficiency
KW  - immunological reactions
KW  - tumor necrosis factor
KW  - Animal Models of Human Diseases (VV400) (New March 2000)
KW  - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW  - Host Resistance and Immunity (HH600) 
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TY  - JOUR
T1  - Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL-12 and up-regulation of Th2 cytokines that inhibit macrophage activation.
AU  - Oswald, I. P.
AU  - Caspar, P.
AU  - Wynn, T. A.
AU  - Scharton-Kersten, T.
AU  - Williams, M. E.
AU  - Hieny, S.
AU  - Sher, A.
AU  - James, S. L.
JO  - European Journal of Immunology
JF  - European Journal of Immunology
Y1  - 1998///
VL  - 28
IS  - 6
SP  - 1762
EP  - 1772
SN  - 0014-2980
AD  - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990803305.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2.  Subject Subsets: Helminthology
N2  - In contrast to most inbred strains, P mice failed to develop significant resistance to Schistosoma mansoni infection as a result of vaccination with either irradiation-attenuated cercariae or schistosome antigens plus Bacillus Calmette Guérin, and this failure correlated with defects in macrophage larvicidal activity. Supernatant fluids from antigen-treated in vitro cultures of splenocytes from vaccinated P mice demonstrated less macrophage stimulatory activity than supernatants from cells of vaccine-responsive strains such as C57BL/6. This was not due either to diminished production of the macrophage-activating cytokine interferon (IFN)-γ by P mice, or to a lesser responsiveness of macrophages from P mice to activation by IFN-γ. Instead, P splenocytes produced 2- to 3-fold higher amounts of interleukin (IL)-4 and IL-10, which down-regulate the cytotoxic potential of IFN-γ-treated macrophages. Thus, the macrophage-activating potential of cytokine preparations from vaccinated P mice can be completely recovered by in vitro treatment with antibodies to IL-4 or IL-10. Lower levels of IL-12, which is involved in promoting development of Th1 responses, were produced by splenocytes from P as compared to C57BL/6 mice. The results indicate that a genetic predisposition toward impaired production of IL-12 and increased production of down-regulatory Th2 cytokines correlate with low response to vaccination against S. mansoni.
KW  - cercariae
KW  - cytokines
KW  - disease resistance
KW  - experimental infections
KW  - helminths
KW  - immune response
KW  - immunization
KW  - in vitro
KW  - interferon
KW  - interleukin 10
KW  - interleukin 4
KW  - irradiated vaccines
KW  - laboratory animals
KW  - macrophages
KW  - parasites
KW  - strains
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - resistance to disease
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human herpesvirus 8 (HHV-8) in the pathogenesis of Kaposi's sarcoma and other diseases.
AU  - Humphrey, R. W.
AU  - Davis, D. A.
AU  - Newcomb, F. M.
AU  - Yarchoan, R.
JO  - Leukemia and Lymphoma
JF  - Leukemia and Lymphoma
Y1  - 1998///
VL  - 28
IS  - 3/4
SP  - 255
EP  - 264
SN  - 1042-8194
AD  - Humphrey, R. W.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982004287.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Registry Number: 63585-09-1. 
N2  - The discovery of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV-8) and subsequent studies of this virus have provided a body of evidence that support the concept that this is an aetiologic agent for Kaposi's sarcoma (KS). Several studies have indicated that this virus may also be a causal agent for primary effusion lymphomas (PEL) and Castleman's disease. First generation serological assays for HHV-8 have now been developed. The preponderance of data suggest that the incidence of HHV-8 infection is highest in populations at risk for KS: male homosexuals, immunosuppressed patients, and those who live in endemic regions. HHV-8 encodes for functional homologues of human proteins that may play a role in the development of disease. As we learn more about the steps by which this virus can lead to KS and/or other diseases, rational therapies and preventative strategies may be possible.
KW  - acquired immune deficiency syndrome
KW  - antigens
KW  - B lymphocytes
KW  - cell lines
KW  - drugs
KW  - foscarnet sodium
KW  - homosexuality
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunosuppression
KW  - infection
KW  - Kaposi's sarcoma
KW  - lymphoma
KW  - males
KW  - neoplasms
KW  - pathogenesis
KW  - pathogenicity
KW  - patients
KW  - phenotypes
KW  - populations
KW  - proteins
KW  - reviews
KW  - sarcoma
KW  - serology
KW  - surface antigens
KW  - surface proteins
KW  - Herpesviridae
KW  - human herpesvirus 8
KW  - man
KW  - mice
KW  - viruses
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - AIDS
KW  - antigenicity
KW  - B cells
KW  - cancers
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - immunogens
KW  - Kaposi's sarcoma-associated herpesvirus
KW  - mechanisms
KW  - medicines
KW  - membrane proteins
KW  - pharmaceuticals
KW  - trisodium phosphonoformate
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - National institutes of health (USA): role in tropical medicine research.
AU  - Western, K. A.
JO  - Southeast Asian Journal of Tropical Medicine and Public Health
JF  - Southeast Asian Journal of Tropical Medicine and Public Health
Y1  - 1998///
VL  - 29
IS  - 2
SP  - 316
EP  - 318
SN  - 0125-1562
AD  - Western, K. A.: Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19992002721.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English. 
KW  - public health
KW  - research
KW  - tropical medicine
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Joint International Tropical Medicine Meeting
KW  - studies
KW  - United States of America
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Health Services (UU350) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Review of epidemiologic studies of alcohol and prostate cancer: 1971-1996.
AU  - Breslow, R. A.
AU  - Weed, D. L.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1998///
VL  - 30
IS  - 1
SP  - 1
EP  - 13
SN  - 0163-5581
AD  - Breslow, R. A.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001412662.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Subject Subsets: Human Nutrition
N2  - Prostate cancer is the most common cancer among American men, with few established risk factors. The association between prostate cancer and alcohol, a potentially modifiable risk factor, has been examined in numerous studies. The literature on alcohol and the incidence of prostate cancer was reviewed by searching for published cohort and case-control studies using computerized databases, references, and experts, by evaluating studies for validity, and by summarizing the results and providing research recommendations. There was compelling evidence for no association between low-to-moderate alcohol consumption and prostate cancer. Most studies, however, did not assess the risk of heavy drinking, where there has been some suggestion of increased risk, or of lifetime patterns of drinking. None of the studies have used genetic markers, nor have they been conducted in populations with known familial risk.
KW  - alcoholic beverages
KW  - epidemiology
KW  - genetic factors
KW  - neoplasms
KW  - prostate
KW  - reviews
KW  - risk factors
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412662&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix.
AU  - Wideroff, L.
AU  - Potischman, N.
AU  - Glass, A. G.
AU  - Greer, C. E.
AU  - Manos, M. M.
AU  - Scott, D. R.
AU  - Burk, R. D.
AU  - Sherman, M. E.
AU  - Wacholder, S.
AU  - Schiffman, M.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1998///
VL  - 30
IS  - 2
SP  - 130
EP  - 136
SN  - 0163-5581
AD  - Wideroff, L.: Applied Research Branch, Division of Cancer Control and Population Science, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001412968.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 50-81-7, 7235-40-7, 59-30-3, 68-26-8, 1406-18-4, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - Several earlier case-control studies reported inverse associations of cervical squamous intraepithelial lesions (SIL) with high dietary or biomarker levels of carotenoids, folate, and vitamins C and E. However, most studies did not measure the primary causal factor, cancer-associated genital human papillomaviruses (HPV), now detected by sensitive viral DNA tests. This nested case-control study assessed whether high dietary intakes of these nutrients, plus zinc and vitamin A, reduced SIL risk in cancer-associated HPV DNA-positive women. Using a 60-item food-frequency questionnaire, nutrient estimates were obtained for 33 incident cases with high-grade lesions, 121 with low-grade lesions, 97 with equivocal SIL, and 806 cytologically normal controls sampled from a large prospective cohort study. Baseline cervicovaginal lavages were tested for HPV DNA by the polymerase chain reaction. Among DNA-positive cases (n=68) and controls (n=69), age-adjusted odds ratios (ORs) of SIL in the highest vs. the lowest nutrient quartiles were 1.4 [95% confidence interval (CI)=0.5-4.2] for vitamin A, 0.6 (CI=0.2-2.0) for β-carotene, 1.3 (CI=0.4-3.6) for vitamin C, 1.0 (CI=0.4-3.6) for vitamin E, 0.7 (CI=0.3-2.1) for folate, and 0.8 (CI=0.3-2.2) for zinc. ORs in HPV DNA-negative women approximated 1.0, with the exception of vitamin E (OR=0.5, CI=0.3-0.9). These results do not support a protective role for the above nutrients against low-grade or equivocal SIL, which constituted the majority of diagnoses in this study.
KW  - ascorbic acid
KW  - beta-carotene
KW  - carcinogenesis
KW  - carotenoids
KW  - cervical cancer
KW  - cervix
KW  - diets
KW  - epithelium
KW  - folic acid
KW  - intake
KW  - lesions
KW  - neoplasms
KW  - nutrients
KW  - questionnaires
KW  - ratios
KW  - retinol
KW  - surveys
KW  - vitamin E
KW  - vitamins
KW  - zinc
KW  - axerophthol
KW  - cancers
KW  - folacin
KW  - folate
KW  - tetraterpenoids
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412968&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecules in focus. Leptin.
AU  - Prolo, P.
AU  - Wong MaLi
AU  - Licinio, J.
JO  - International Journal of Biochemistry & Cell Biology
JF  - International Journal of Biochemistry & Cell Biology
Y1  - 1998///
VL  - 30
IS  - 12
SP  - 1285
EP  - 1290
AD  - Prolo, P.: Unit on Clinical Research, Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA.
N1  - Accession Number: 19991401060.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1, 169494-85-3.  Subject Subsets: Human Nutrition
N2  - A review.
KW  - body weight
KW  - hydrocortisone
KW  - leptin
KW  - obesity
KW  - reproduction
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cortisol
KW  - fatness
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991401060&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tea and coffee consumption and risk of colon and rectal cancer in middle-aged Finnish men.
AU  - Hartman, T. J.
AU  - Tangrea, J. A.
AU  - Pietinen, P.
AU  - Malila, N.
AU  - Virtanen, M.
AU  - Taylor, P. R.
AU  - Albanes, D.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1998///
VL  - 31
IS  - 1
SP  - 41
EP  - 48
CY  - Mahwah; USA
PB  - Lawrence Erlbaum Associates Inc.
SN  - 0163-5581
AD  - Hartman, T. J.: Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20003007116.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Subject Subsets: Public Health; Human Nutrition
N2  - The association between coffee and black tea consumption and the subsequent risk of colon and rectal cancer was investigated within a Finnish clinical trial cohort. One hundred eleven cases of colon cancer and 83 cases of rectal cancer were diagnosed over a median of 8.0 years of follow-up. Proportional hazards regression models were used to derive adjusted relative risks (RR) and 95% confidence intervals (CI) for the association between coffee and tea consumption and cancer incidence. After controlling for confounders, coffee was not significantly associated with colon or rectal cancer. A positive association was seen for increased consumption of tea drinking and colon cancer. Compared with persons who did not drink tea, those who consumed &lt;1 cup/day had an RR of 1.40 (95% CI=0.84-2.33) and those who consumed ≥1 cup/day had an RR of 2.09 (95% CI=1.34-3.26, p for trend=0.001). In contrast, tea consumption had little effect on rectal cancer incidence. This study does not support the hypothesis that coffee and tea protect against colorectal cancer risk. However, given the strength of the tea-colon cancer association and the significant gradient of risk we observed across level of intake, further epidemiologic research of this relationship in other populations seems warranted.
KW  - coffee
KW  - colon
KW  - consumption
KW  - human diseases
KW  - men
KW  - neoplasms
KW  - rectum
KW  - risk
KW  - tea
KW  - Finland
KW  - Camellia sinensis
KW  - Coffea
KW  - man
KW  - Camellia
KW  - Theaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Rubiaceae
KW  - Rubiales
KW  - Gentianales
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003007116&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased retinol binding protein in the sera of patients with severe ischemic damage of the liver after transplantation.
AU  - Mastroianni, A.
AU  - Regalia, E.
AU  - Facchetti, G.
AU  - Longoni, P. D.
AU  - Formelli, F.
AU  - Pulvirenti, A.
AU  - Mazzaferro, V.
JO  - Clinical Biochemistry
JF  - Clinical Biochemistry
Y1  - 1998///
VL  - 31
IS  - 2
SP  - 113
EP  - 116
SN  - 0009-9120
AD  - Mastroianni, A.: Division of Clinical Chemistry and Microbiology, Liver Transplantation Unit, National Cancer Institute, via Venezian 1, 20133 Milano, Italy.
N1  - Accession Number: 19981411213.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Serum samples were obtained from 14 patients who had undergone orthotopic liver transplantation in Italy 2 weeks after the surgery and then once a month during the first year posttransplantation [date not given]. Retinol binding protein was measured in the samples by immunonephelometry. The patients were divided into 2 groups on the basis of early (first 10 days) postoperative graft function; group 1, 6 patients with severe ischaemic damage; and group II, 8 patients with moderate-severe liver dysfunction. The mean retinol binding protein concentration at one year of follow-up was persistently higher in group I than in group II (83.1±33.4 vs. 44.6±20.7 mg/litre, P&lt;0.001). Retinol binding protein concentrations remained higher in patients of group I even when the other biochemical parameters of liver function returned to normal. The increase in retinol binding protein serum concentrations was independent of variation in other parameters of liver and kidney function, but was correlated with an increase in transthyretin and retinol concentrations. It is suggested that the results show a close relationship between a permanent high retinol binding protein concentration and severe graft injury after liver transplantation.
KW  - binding proteins
KW  - blood
KW  - liver
KW  - liver transplant
KW  - retinol
KW  - transplantation
KW  - transthyretin
KW  - vitamins
KW  - Italy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - axerophthol
KW  - carrier proteins
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mammary gland carcinogenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Sprague-Dawley rats on high- and low-fat diets.
AU  - Snyderwine, E. G.
AU  - Thorgeirsson, U. P.
AU  - Meenakshi Venugopal
AU  - Roberts-Thomson, S. J.
JO  - Nutrition and Cancer
JF  - Nutrition and Cancer
Y1  - 1998///
VL  - 31
IS  - 3
SP  - 160
EP  - 167
CY  - Mahwah; USA
PB  - Lawrence Erlbaum Associates Inc.
SN  - 0163-5581
AD  - Snyderwine, E. G.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20003007239.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic amine derived from cooked meat. Mammary gland tumours were induced in female Sprague-Dawley rats given 10 doses of PhIP (75 mg/kg po) once per day from 43 days of age and then placed on a defined high-fat (23.5% corn [maize] oil) or low-fat (5% corn oil) diet for 25 weeks. Mammary tumour incidence was 49% (44 of 90 rats) and 31% (27 of 88 rats) in the high- and low-fat groups, respectively. No tumours were found in vehicle control rats on the high- or the low-fat diet (n=44 and 43, respectively). The higher tumour incidence in the high-fat group was due to an increase specifically in carcinomas (classified as tubulopapillary carcinomas) rather than benign tumours (tubular adenomas and fibroadenomas). The incidence of carcinomas was 45 and 24% in PhIP-treated rats on the high- and low-fat diets, respectively. In addition, the percentage of carcinomas showing stromal invasion was highest in the high-fat diet group (22 vs. 8%, high- vs. low-fat diet). Proliferating cell nuclear antigen immunostaining (PCNA) index revealed six times more proliferation in carcinomas from rats on the high-fat diet than in rats on the low-fat diet. Adenomas from rats on different diets had similar PCNA indexes. The tumour apoptotic index, quantitated by immunohistochemical detection (terminal deoxynucleotidyl transferase nick end labelling), was twice as high in carcinomas from rats on the high-fat diet as in carcinomas from rats on the low-fat diet but was similar between the two groups of adenomas. The PCNA-to-apoptosis ratio was 43 and 17 in carcinomas from rats on the high- and low-fat diets, respectively, indicating that the growth rate of carcinomas was greater in rats on the high-fat diet. The results from this study show that the high-fat diet increases the incidence, invasiveness, and growth of PhIP-induced mammary gland carcinomas.
KW  - animal models
KW  - breast cancer
KW  - diet
KW  - dietary fat
KW  - fats
KW  - heterocyclic nitrogen compounds
KW  - mammary glands
KW  - neoplasms
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - source fat
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Non-Hodgkin's lymphoma and agricultural use of the insecticide lindane.
AU  - Blair, A.
AU  - Cantor, K. P.
AU  - Zahm, S. H.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1998///
VL  - 33
IS  - 1
SP  - 82
EP  - 87
SN  - 0271-3586
AD  - Blair, A.: Occupational Epidemiology Branch, National Cancer Institute, EPN Room 418, Bethesda, MD 20892-7364, USA.
N1  - Accession Number: 19991100958.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4, 333-41-5, 608-73-1, 58-89-9.  Subject Subsets: Agricultural Entomology
N2  - Data from population-based case-control studies of non-Hodgkin's lymphoma among white men from Kansas, Nebraska, Iowa, and Minnesota were pooled to evaluate potential risks from environmental exposures, while controlling for potential confounding factors. These data provided the opportunity to evaluate the risk of non-Hodgkin's lymphoma from potential exposures to lindane. This pooled data set included 987 individuals with non-Hodgkin's lymphoma and 2895 population-based controls. Information was obtained by telephone or in person interviews, which included detailed questions on farm practices and agricultural use of chemicals. Reported use of lindane significantly increased the risk of non-Hodgkin's lymphoma by 50%. Some use characteristics were suggestive of an association. Odds ratios (ORs) were greater among persons who first used the pesticide 20 years before diagnosis (OR = 1.7) than more recently (OR = 1.3), among those who reported more frequent use (OR = 2.0 for use 5 or more days/year versus 1.6 for fewer than five days/year), and from use on crops (OR = 1.9), rather than from use on animals (OR = 1.3), although these differences were not statistically significant. On the other hand, ORs were lower when based on direct interviews (OR = 1.3) than on data from proxy respondents (OR = 2.1) and adjustment for potential confounding by use of 2,4-D and diazinon reduced the ORs associated with lindane use from 1.5 to 1.2 and 1.3, respectively. It is concluded that lindane does not appear to be a major aetiologic factor in the development of non-Hodgkin's lymphoma, although a small role cannot be ruled out.
KW  - 2,4-D
KW  - agricultural entomology
KW  - diazinon
KW  - HCH
KW  - insecticides
KW  - lindane
KW  - non-Hodgkin's lymphoma
KW  - nontarget effects
KW  - pesticides
KW  - Iowa
KW  - Kansas
KW  - Minnesota
KW  - Nebraska
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - Great Plains States of USA
KW  - Northern Plains States of USA
KW  - Lake States of USA
KW  - (2,4-dichlorophenoxy)acetic acid
KW  - benzene hexachloride
KW  - BHC
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration.
AU  - Kaufman, H. L.
AU  - Roden, M.
AU  - Nathanson, D.
AU  - Basso, T. M.
AU  - Schwartzentruber, D. J.
AU  - Holland, S. M.
JO  - Journal of Pediatric Surgery
JF  - Journal of Pediatric Surgery
Y1  - 1998///
VL  - 33
IS  - 5
SP  - 761
EP  - 763
SN  - 0022-3468
AD  - Kaufman, H. L.: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992000392.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 9008-11-1. 
KW  - bacterial diseases
KW  - case reports
KW  - children
KW  - clinical aspects
KW  - drug therapy
KW  - human diseases
KW  - interferon
KW  - leukopenia
KW  - mycobacterial diseases
KW  - splenectomy
KW  - splenomegaly
KW  - USA
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium avium complex
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - chemotherapy
KW  - clinical picture
KW  - mycobacterial infections
KW  - panleukopenia
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000392&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - AIDS: a role for host genes.
AU  - O'Brien, S. J.
JO  - Hospital Practice
JF  - Hospital Practice
Y1  - 1998///
VL  - 33
IS  - 7
SP  - 53
EP  - 79
SN  - 0018-5809
AD  - O'Brien, S. J.: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA.
N1  - Accession Number: 19982010941.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref.
N2  - Suspicion that human genes affect the natural history of AIDS has been confirmed by discoveries of three such genes, one of which confers near-total immunity in about 1% of Caucasians. The findings suggest a novel therapeutic target: not HIV but the host's cooperation with it. They also herald an era in which genomes are seen as having been shaped by the evolutionary pressures of infection, and may thus hold evolution-tested therapies.
KW  - acquired immune deficiency syndrome
KW  - genes
KW  - genomes
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunity
KW  - infection
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Construction of stable episomes in Cryptococcus neoformans.
AU  - Varma, A.
AU  - Kwon-Chung, K. J.
JO  - Current Genetics
JF  - Current Genetics
Y1  - 1998///
VL  - 34
IS  - 1
SP  - 60
EP  - 66
SN  - 0172-8083
AD  - Varma, A.: Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991200124.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - The generation of stable plasmids constructed by inserting specific DNA sequences into previously known unstable vectors is reported. These sequences were obtained from a DNA library recovered from a previously reported stable minichromosome created by electroporative transformation in C. neoformans. A 6-kb insert from this minichromosome significantly enhanced both the frequencies at which URA5 transformants were obtained as well as the stability of their uracil prototrophy on non-selective media. A 1.5-kb sequence of this insert contained telomeric sequence repeats which when introduced into plasmids resulted in significant increases in transformation frequency. A 1081-bp sequence (STAB), present in the remainder of the insert, had an ARS-like function enhancing the episomal maintenance of plasmids in the transformants regardless of the gene (ADE2/URA5) used as a selection marker.
KW  - DNA
KW  - DNA libraries
KW  - genetics
KW  - nucleotide sequences
KW  - plasmid vectors
KW  - Cryptococcus neoformans
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200124&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occupational risk factors and prostate cancer in U.S. blacks and whites.
AU  - Krstev, S.
AU  - Baris, D.
AU  - Stewart, P.
AU  - Dosemeci, M.
AU  - Swanson, G. M.
AU  - Greenberg, R. S.
AU  - Schoenberg, J. B.
AU  - Schwartz, A. G.
AU  - Liff, J. M.
AU  - Hayes, R. B.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1998///
VL  - 34
IS  - 5
SP  - 421
EP  - 430
SN  - 0271-3586
AD  - Krstev, S.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
N1  - Accession Number: 19992007328.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref.
N2  - Occupational risk factors for prostate cancer were investigated in a large case control study among black and white subjects from the USA. The study included 981 new pathologically-confirmed prostate cancer cases (479 blacks and 502 whites) diagnosed during 1986-89, and 1315 population controls (594 blacks and 721 whites) who resided in Atlanta, Detroit, and 10 counties in New Jersey, covered by population-based cancer registries. Information on occupation, including a lifetime work history, was collected by in-person interview. No clear patterns of risk were found for U.S. whites versus blacks, nor for white-collar versus blue-collar jobs. Farming was related to prostate cancer (OR=2.17; 95% CI=1.18-3.98). Risk was restricted, however, to short-term workers and workers in crop production. Risk was not limited to those farming after 1950, when widespread use of pesticides started. Risks increased with increasing years of employment in firefighting (χ²trend, P=0.02) and power plant operations (χ²trend, P=0.03) and were elevated among long-term railroad line-haulers (OR=5.85; 95% CI=1.25-27.4); jobs with potential polycyclic aromatic hydrocarbon (PAH) exposures. Risk was elevated among athletes (OR=5.38; 95% CI=1.48-19.6). However, most of the cases were athletes before 1960, so the potential use of anabolic steroids was excluded. Although some clues about potential occupational associations were found, the overall results showed that occupation is not a major determinant of prostate cancer risk.
KW  - blacks
KW  - carcinoma
KW  - epidemiology
KW  - ethnic groups
KW  - human diseases
KW  - neoplasms
KW  - occupational health
KW  - prostate
KW  - risk factors
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Occupational risk factors for breast cancer among women in Shanghai.
AU  - Petralia, S. A.
AU  - Chow WongHo
AU  - McLaughlin, J.
AU  - Jin Fan
AU  - Gao YuTang
AU  - Dosemeci, M.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1998///
VL  - 34
IS  - 5
SP  - 477
EP  - 483
SN  - 0271-3586
AD  - Petralia, S. A.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992007330.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
N2  - Data collected by the Shanghai Cancer Registry and the Chinese Third National Census were used to study the risk of breast cancer by occupation and by occupational exposures. Standardized incidence ratios (SIRs) were used to compare observed cases to expected numbers of cases, based on the incidence rates for Shanghai and the number of women in each occupation according to the 1982 census. Statistically elevated SIRs for breast cancer were seen for a number of professional occupational categories, with the greatest risk seen among scientific research workers (SIR=3.3). Administrative clerks, political and security personnel, and makers of rubber and plastics products also had significant excesses. Significant deficits of risk were seen for the categories of production and related workers, construction workers, and transportation equipment operators. For specific occupations, the highest SIRs were observed among doctors of Chinese-Western medicine (SIR=14.7, 95% CI=5.9-30.3) and doctors of Chinese medicine (SIR=7.2, 95% CI=4.4-11.4). Excesses were also found among teachers at each level of education, librarians, clerical workers, electrical and electronic engineers, nurses, lab technicians, accountants and book-keepers, rubber manufacturing products makers, weavers and knitters. SIRs were significantly elevated for high probability of exposure to organic solvents (SIR=1.4). For benzene exposure, significant excesses were found for overall exposure (SIR=1.1) and for medium level of exposure (SIR=1.3). There was no evidence of an association between risk and electromagnetic fields (EMF) exposure. Based on a small number of exposed, SIRs were elevated for both medium probability and high level of exposure to pesticides.
KW  - breast cancer
KW  - chemicals
KW  - epidemiology
KW  - exposure
KW  - human diseases
KW  - neoplasms
KW  - occupational health
KW  - pesticides
KW  - risk factors
KW  - women
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancers
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007330&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Exposure opportunities of families of farmer pesticide applicators.
AU  - Gladen, B. C.
AU  - Sandler, D. P.
AU  - Zahm, S. H.
AU  - Kamel, F.
AU  - Rowland, A. S.
AU  - Alavanja, M. C. R.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1998///
VL  - 34
IS  - 6
SP  - 581
EP  - 587
SN  - 0271-3586
AD  - Gladen, B. C.: Biostatistics Branch, Mail Drop A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19992008130.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
N2  - Subjects were 26 793 licensed private pesticide applicators enrolled in the Agricultural Health Study, a cohort study being conducted in Iowa and North Carolina, USA. Questionnaires were completed by the applicators and their spouses. Many indirect exposure opportunities exist; for example, 21% of homes are within 50 yards of pesticide mixing areas, 27% of applicators store pesticides in their homes, and 94% of clothing worn for pesticide work is washed in the same machine as other laundry. Direct exposure opportunities also occur; for example, 51% of wives of applicators worked in the fields in the last growing season, 40% of wives have ever mixed or applied pesticides, and over half of children aged 11 or more do farm chores. It is concluded that the extent of the opportunities for exposure of family members of farmer pesticide applicators makes studies of their health important.
KW  - agriculture
KW  - children
KW  - clothing
KW  - exposure
KW  - families
KW  - farmers
KW  - homes
KW  - pesticides
KW  - spraymen
KW  - Iowa
KW  - North Carolina
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - South Atlantic States of USA
KW  - apparel
KW  - clothes
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008130&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Megestrol acetate for anorexia in patients with far-advanced cancer: a double-blind controlled clinical trial.
AU  - Conno, F. de
AU  - Martini, C.
AU  - Zecca, E.
AU  - Balzarini, A.
AU  - Venturino, P.
AU  - Groff, L.
AU  - Caraceni, A.
JO  - European Journal of Cancer
JF  - European Journal of Cancer
Y1  - 1998///
VL  - 34
IS  - 11
SP  - 1705
EP  - 1709
SN  - 0959-8049
AD  - Conno, F. de: Pain Therapy, Rehabilitation and Palliative Care Division, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy.
N1  - Accession Number: 19981417446.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 3562-63-8, 595-33-5.  Subject Subsets: Human Nutrition
N2  - The effects of a low-dose regimen of megestrol acetate (MA; 320 mg/day) on appetite in advanced cancer patients in Italy were evaluated. Out-patients with far-advanced non-hormone responsive tumours and loss of appetite were randomized in a phase III trial, with 2 consecutive phases: a 14-day double-blind placebo controlled phase (phase A) and a 76-day open phase (phase B). During phase A, patients were treated with MA, two 160 mg tablets/day, or placebo. In phase B, the MA dose was titrated to clinical response in both groups. Appetite, food intake, body weight, performance status, mood and quality of life were evaluated with standardized measures; patients' global judgement about treatment efficacy was also requested. Of 42 patients entering the study, 33 (17 MA and 16 placebo) were evaluable for efficacy. The appetite score improved significantly with MA after 7 days (P=0.0023), and this effect was still significant at 14 days (P=0.0064). Patients judged the treatment with MA effective in 88.2% of cases (14th day), whilst placebo was considered effective by 25% (P=0.0003). None of the other measures showed significant changes during treatment. The remarkable effect on appetite evident after 7 days, without serious side-effects, shows that MA can produce significant subjective effects at a low-dose even in patients with far-advanced disease.
KW  - anorexia
KW  - appetite
KW  - body weight
KW  - drug therapy
KW  - food intake
KW  - megestrol
KW  - neoplasms
KW  - quality of life
KW  - Italy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - cancers
KW  - chemotherapy
KW  - inappetence
KW  - megestrol acetate
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Correlation between human papillomavirus DNA detection in maternal cervical smears and buccal swabs of infants.
AU  - Chatterjee, R.
AU  - Mukhopadhyay, D.
AU  - Murmu, N.
AU  - Mitra, P. K.
JO  - Indian Journal of Experimental Biology
JF  - Indian Journal of Experimental Biology
Y1  - 1998///
VL  - 36
IS  - 2
SP  - 199
EP  - 202
SN  - 0019-5189
AD  - Chatterjee, R.: Department of Tumor Virology, Chittarajan National Cancer Institute, 37 S P Mukherjee Road, Calcutta 700 026, India.
N1  - Accession Number: 19982007517.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9007-49-2.  Subject Subsets: Tropical Diseases
N2  - The presence of human papillomavirus (HPV) in exfoliated cervical cells of pregnant women was evaluated, and the pattern of HPV transmission from Indian mothers to their neonates at birth was studied. Cervical smear cells were collected about 24 h before childbirth from 30 unselected pregnant women. Buccal swabs were collected 24 h after birth from the corresponding 31 infants (1 set of twins). The study was limited to HPV types 6/11, 16/18 and 31/33/35. HPV DNA was detected among 40% of the women (n=12), and HPV DNA was transmitted into the oral cavities of 5 (41.6%) infants from the 12 HPV-positive mothers. Maternal-infant transmission was highest for HPV 6/11 (66.6%), whereas HPV 16/18 occurred in 20% of the total cases.
KW  - cervix
KW  - DNA
KW  - human diseases
KW  - infants
KW  - maternal transmission
KW  - neonates
KW  - pregnancy
KW  - viral diseases
KW  - India
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - Papillomaviridae
KW  - deoxyribonucleic acid
KW  - gestation
KW  - human papillomavirus
KW  - mother to child transmission
KW  - newborn infants
KW  - Papovaviridae
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Concentrations of airborne Aspergillus compared to the incidence of invasive aspergillosis: lack of correlation.
AU  - Hospenthal, D. R.
AU  - Kwon-Chung, K. J.
AU  - Bennett, J. E.
JO  - Medical Mycology
JF  - Medical Mycology
Y1  - 1998///
VL  - 36
IS  - 3
SP  - 165
EP  - 168
AD  - Hospenthal, D. R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202086.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Air sampling of the rooms and corridors of the oncology wards of the National Institutes of Health Clinical Center, Bethesda, MD, USA, was carried out during a 54-week period (autumn 1974-autumn 1975) to assess the concentration of viable Aspergillus conidia. A. fumigatus and A. flavus were recovered at a mean of 1.83 cfu/m³ air sampled. Individual samplings yielded concentrations of up to 11.6 cfu/m³. Other Aspergillus spp. were recovered at a mean of 2.38 cfu/m³ (maximum 32.6 cfu/m³). Concentration was not correlated with season or hospital ward. Review of postmortem examination results showed a mean of 6.6 cases of aspergillosis annually over a 22-year period (1956-77). No seasonal variation in case incidence was found. Six cases of invasive aspergillosis were diagnosed on the 3 cancer wards during the air sampling period, but no association was seen linking these cases with changes in recovery of airborne Aspergillus. A seasonal pattern was not observed in the overall incidence of aspergillosis cases nor concentrations of airborne conidia.
KW  - air
KW  - aspergillosis
KW  - contamination
KW  - disease transmission
KW  - epidemiology
KW  - hospitals
KW  - human diseases
KW  - nosocomial infections
KW  - Maryland
KW  - USA
KW  - Aspergillus
KW  - Aspergillus flavus
KW  - Aspergillus fumigatus
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Aspergillus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fungus
KW  - hospital infections
KW  - Hyphomycetes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings.
AU  - Sinha, R.
AU  - Rothman, N.
AU  - Salmon, C. P.
AU  - Knize, M. G.
AU  - Brown, E. D.
AU  - Swanson, C. A.
AU  - Rhodes, D.
AU  - Rossi, S.
AU  - Felton, J. S.
AU  - Levander, O. A.
JO  - Food and Chemical Toxicology
JF  - Food and Chemical Toxicology
Y1  - 1998///
VL  - 36
IS  - 4
SP  - 279
EP  - 287
SN  - 0278-6915
AD  - Sinha, R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza North, Rm 430, 6130 Executive Blvd, Rockville, MD 20892, USA.
N1  - Accession Number: 19981411274.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - Heterocyclic amines (HCA) ([2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP)]) were determined in cooked beef using solid-phase extraction and HPLC. Steak and hamburger patties were pan-fried, oven-broiled and grilled/barbecued to 4 levels of doneness (rare, medium, well done or very well done), while beef roasts were oven cooked to 3 levels of doneness (rare, medium or well done). HCA varied with the cut of beef, cooking method and doneness level. In general, MeIQx content increased with doneness under each cooking condition for steak and hamburger patties, up to 8.2 ng/g. PhIP was the predominant HCA produced in steak (1.9-30.0 ng/g), but was formed only in very well done fried or grilled hamburger. DiMeIQx was found in trace levels in pan-fried steaks only, while IQ and MeIQ were not detectable in any of the samples. Roast beef did not contain any of the HCA, but the gravy made from the drippings from well done roasts had 2 and 7 ng/g of PhIP and MeIQx, respectively. It is concluded that epidemiological studies need to consider the type of meat, cooking method and degree of doneness/surface browning in survey questions to adequately assess the exposure of an individual to HCA.
KW  - amines
KW  - beef
KW  - composition
KW  - cooking
KW  - frying
KW  - heterocyclic nitrogen compounds
KW  - meat cuts
KW  - meat products
KW  - roasting
KW  - steaks
KW  - Meat Produce (QQ030) 
KW  - Food Composition and Quality (QQ500) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Spinal extradural cysticercosis: a case report.
AU  - Mohanty, A.
AU  - Das, S.
AU  - Kolluri, V. R. S.
AU  - Das, B. S.
JO  - Spinal Cord
JF  - Spinal Cord
Y1  - 1998///
VL  - 36
IS  - 4
SP  - 285
EP  - 287
AD  - Mohanty, A.: Department of Neurosurgery, National Institute of Mental Health & Neuro Sciences, Bangalore, India.
N1  - Accession Number: 19990800167.  Publication Type: Journal Article.  Language: English.  Number of References: 7 ref. Registry Number: 54965-21-8.  Subject Subsets: Helminthology; Tropical Diseases
N2  - A rare case of extradural spinal cysticercosis (caused by Taenia solium) in a 55-year-old man from India is presented. The patient presented with paraesthesiae and progressive weakness in all limbs of 5 months duration. He had evidence of extradural granulation tissue with associated destruction of C4 and C5 pedicles and laminae, causing tetraparesis. Histopathological examination revealed evidence of a degenerated cysticercal cyst with host tissue reaction. The patient showed a gradual and marked improvement after surgical decompression and a 4-week course of 15 mg/kg albendazole supplemented with corticoids for the first 2 weeks. Although rare, cysticercosis as a possible aetiology of extradural spinal compression in endemic areas.
KW  - aetiology
KW  - albendazole
KW  - anthelmintics
KW  - case reports
KW  - cestode infections
KW  - cestode larvae
KW  - clinical aspects
KW  - corticoids
KW  - cysticercosis
KW  - drug therapy
KW  - helminths
KW  - histopathology
KW  - human diseases
KW  - metacestodes
KW  - parasites
KW  - pathology
KW  - spine
KW  - surgery
KW  - treatment
KW  - India
KW  - man
KW  - Taenia solium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - causal agents
KW  - chemotherapy
KW  - clinical picture
KW  - corticosteroids
KW  - etiology
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness.
AU  - Sinha, R.
AU  - Knize, M. G.
AU  - Salmon, C. P.
AU  - Brown, E. D.
AU  - Rhodes, D.
AU  - Felton, J. S.
AU  - Levander, O. A.
AU  - Rothman, N.
JO  - Food and Chemical Toxicology
JF  - Food and Chemical Toxicology
Y1  - 1998///
VL  - 36
IS  - 4
SP  - 289
EP  - 297
SN  - 0278-6915
AD  - Sinha, R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza North, Rm 430, 6130 Executive Blvd, Rockville, MD 20892, USA.
N1  - Accession Number: 19981411275.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Human Nutrition; Pig Science
N2  - The concentrations of the heterocyclic amines (HCA) 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethyl-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were measured in pork chops, ham slices, bacon and pork sausages cooked by different techniques and to varying levels of doneness. Pork chops and ham slices were pan-fried and oven-broiled; bacon was pan-fried, oven-broiled or microwaved; hot dogs were pan-fried, oven-broiled, grilled/barbecued or boiled; sausages and patties were pan-fried. All the products were cooked until just done, well done or very well done. HCA type and level varied by pork product, cooking method and doneness level. The highest PhIP levels were found in well done and very well done oven-broiled bacon; for very well done 30.3 and 4.0 ng/g of meat of PhIP and MeIQx, respectively. Pan-fried very well done sausage patties contained 5.4 ng/g MeIQx, while sausages contained 1.3 ng/g. MeIQx was formed in well done and very well done pan-fried but not broiled pork chops. Hot dogs or ham slices had low or undetectable levels of HCA. It is concluded that epidemiological studies investigating the relationship between HCA intake and cancer risk need to incorporate type of meat, cooking method and degree of doneness/surface browning into questions to adequately assess the exposure of an individual to HCA.
KW  - amines
KW  - bacon
KW  - cooking
KW  - frying
KW  - ham
KW  - heterocyclic nitrogen compounds
KW  - meat
KW  - meat products
KW  - methodology
KW  - neoplasms
KW  - pigmeat
KW  - sausages
KW  - cancers
KW  - methods
KW  - pork
KW  - Meat Produce (QQ030) 
KW  - Food Composition and Quality (QQ500) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981411275&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats.
AU  - Kusamran, W. R.
AU  - Ratanavila, A.
AU  - Tepsuwan, A.
JO  - Food and Chemical Toxicology
JF  - Food and Chemical Toxicology
Y1  - 1998///
VL  - 36
IS  - 6
SP  - 475
EP  - 484
SN  - 0278-6915
AD  - Kusamran, W. R.: Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute, Bangkok, Thailand.
N1  - Accession Number: 19981414122.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 9035-51-2, 70-18-8, 50812-37-8.  Subject Subsets: Horticultural Science; Human Nutrition; Agroforestry
N2  - The effects of feeding of neem tree flowers (Azadirachta indica var. siamtensis), fruits of Thai and Chinese bitter gourd (Momordica charantia) and leaves of sweet basil (Ocimum basilicum) on the levels of phase I enzymes, (cytochrome P450 (P450), aniline hydroxylase (ANH) and aminopyrine-N-demethylase (AMD)), the capacity to activate the mutagenic potential of aflatoxin B1 (AFB1) and benzo[α]pyrene (BaP), and to induce the phase II enzymes (i.e. glutathione S-transferase (GST)) was studied in the livers of 20 rats. Feeding diets containing 12.5% neem flowers and Thai bitter gourd fruits for 2 weeks increased GST activity, 2.7- and 1.6-fold compared with pair-fed control values, respectively. There was a marked reduction of phase I enzyme activity. Fruits of the Chinese bitter gourd, had no effect on GST activity but decreased AMD activity and the in vitro metabolic activation of AFB1 and BaP. Dietary sweet basil leaves caused a significant increase in GST and all phase I enzymes. Neem flowers and Thai bitter gourd fruits contain monofunctional phase II enzyme inducers and compounds capable of repressing some monooxygenases, especially those involved in the metabolic activation of chemical carcinogens, while sweet basil leaves contain compounds, probably bifunctional inducers, capable of inducing phase I and phase II enzymes and Chinese bitter gourd fruits contain only compounds capable of repressing some monooxygenases. It is concluded that neem flowers and Thai bitter gourd fruits may possess chemopreventive potential, the potential of Chinese bitter gourd fruits and sweet basil leaves are not yet defined.
KW  - aflatoxins
KW  - carcinogens
KW  - cytochrome P-450
KW  - enzyme activity
KW  - enzymes
KW  - glutathione
KW  - glutathione transferase
KW  - hepatotoxins
KW  - in vitro
KW  - inhibition
KW  - leaves
KW  - medicinal properties
KW  - multipurpose trees
KW  - mycotoxins
KW  - trees
KW  - woody plants
KW  - Thailand
KW  - Azadirachta
KW  - Azadirachta indica
KW  - Momordica
KW  - Momordica charantia
KW  - Ocimum basilicum
KW  - plants
KW  - rats
KW  - Meliaceae
KW  - Sapindales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Azadirachta
KW  - Cucurbitaceae
KW  - Violales
KW  - Momordica
KW  - Ocimum
KW  - Lamiaceae
KW  - Lamiales
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - aminopyrine N-demethylase
KW  - aniline hydroxylase
KW  - fungal toxins
KW  - ligandin
KW  - neem
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Crop Produce (QQ050) 
KW  - Non-wood Forest Products (KK540) 
KW  - Agroforestry and Multipurpose Trees; Community, Farm and Social Forestry (KK600) 
KW  - Non-food/Non-feed Plant Products (SS200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414122&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rapid extraction of genomic DNA from medically important yeasts and filamentous fungi by high-speed cell disruption.
AU  - Müller, F. M. C.
AU  - Werner, K. E.
AU  - Kasai, M.
AU  - Francesconi, A.
AU  - Chanock, S. J.
AU  - Walsh, T. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1998///
VL  - 36
IS  - 6
SP  - 1625
EP  - 1629
SN  - 0095-1137
AD  - Müller, F. M. C.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201781.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - A rapid DNA isolation method using high-speed cell disruption (HSCD) incorporating chaotropic reagents and lysing matrices was studied in comparison with standard phenol-chloroform (PC) extraction protocols for isolation of DNA from Candida albicans, Cryptococcus neoformans, Trichosporon beigelii, Aspergillus fumigatus and Fusarium solani. Additional extractions by HSCD were performed on Saccharomyces cerevisiae, Pseudallescheria boydii and Rhizopus arrhizus. Two different inocula (108 and 107 colony forming units (CFU)) were compared for optimization of obtained yields. The entire extraction procedure was performed on as many as 12 samples within 1 h compared with 6 h for PC extraction. In comparison with the PC procedure, HSCD DNA extraction demonstrated significantly greater yields for 108 CFU of C. albicans, T. beigelii, A. fumigatus and F. solani (P≤0.005), 107 CFU of C. neoformans (P≤0.05) and 107 CFU of A. fumigatus (P≤0.01). Yields were within the same range for 108 CFU of C. neoformans and 107 CFU of C. albicans for both HSCD extraction and PC extraction. For 107 CFU of T. beigelii, PC extraction resulted in a greater yield than did HSCD (P≤0.05). Yields obtained from 108 and 107 CFU were significantly greater for filamentous fungi than for yeasts by the HSCD extraction procedure (P&lt;0.0001). By the PC extraction procedure, differences were not significant. For all 8 organisms, the rapid extraction procedure resulted in good yield, integrity and quality of DNA as demonstrated by restriction fragment length polymorphism, PCR and random amplified polymorphic DNA. It is concluded that mechanical disruption of fungal cells by HSCD is a safe, rapid and efficient procedure for extracting genomic DNA from medically important yeasts and especially from filamentous fungi.
KW  - DNA
KW  - extraction
KW  - methodology
KW  - techniques
KW  - Aspergillus fumigatus
KW  - Candida albicans
KW  - Cryptococcus neoformans
KW  - Haematonectria haematococca
KW  - Pseudallescheria boydii
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Trichosporon beigelii
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Fusarium
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Haematonectria
KW  - deoxyribonucleic acid
KW  - fungus
KW  - Fusarium solani
KW  - Hyphomycetes
KW  - methods
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201781&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Invasive infection with Fusarium chlamydosporum in a patient with aplastic anemia.
AU  - Segal, B. H.
AU  - Walsh, T. J.
AU  - Liu, J. M.
AU  - Wilson, J. D.
AU  - Kwon-Chung, K. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1998///
VL  - 36
IS  - 6
SP  - 1772
EP  - 1776
SN  - 0095-1137
AD  - Segal, B. H.: Laboratory of Host Defenses, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201784.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - A case is reported in a 40-year-old woman from Maryland, USA [date not given], with aplastic anaemia, who developed persistent fever and a raised, dark, crusted lesion on the left middle nasal turbinate while receiving immunosuppressive therapy and empirical amphotericin B (0.5 mg/kg daily). The lesion was surgically excised and histological analysis demonstrated invasive hyaline hyphae and some darkly pigmented structures that resembled conidia of dematiaceous molds. The dosage of amphotericin B was increased to 1.0 mg/kg daily and then changed to amphotericin B lipid complex (5 mg/kg daily) due to progressive azotaemia. Sputum culture grew F. chlamydosporum shortly after excision of the lesion. No bone involvement of evidence of progression of the disease was detected over the next few weeks; the patient died of multi-organ failure after undergoing a bone marrow transplantation, with no evidence of residual fusariosis.
KW  - amphotericin B
KW  - aplastic anaemia
KW  - case reports
KW  - drug formulations
KW  - fusariosis
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - lipids
KW  - mycoses
KW  - opportunistic infections
KW  - predisposition
KW  - women
KW  - Maryland
KW  - USA
KW  - Fusarium chlamydosporum
KW  - man
KW  - Fusarium
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aplastic anemia
KW  - fungus
KW  - fusarioses
KW  - Hyphomycetes
KW  - lipins
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201784&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido[2,3-b]indole (AαC) and bioassay of mammary gland carcinogenicity in Sprague-Dawley rats.
AU  - Snyderwine, E. G.
AU  - Sadrieh, N.
AU  - King, R. S.
AU  - Schut, H. A. J.
JO  - Food and Chemical Toxicology
JF  - Food and Chemical Toxicology
Y1  - 1998///
VL  - 36
IS  - 12
SP  - 1033
EP  - 1041
SN  - 0278-6915
AD  - Snyderwine, E. G.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Building 37, Room 3C28, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19990401871.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - Mammary gland carcinogenicity of 2-amino-9H-pyrido[2,3-b]indole (AαC), a heterocyclic amine found at relatively high concentrations in barbecued or grilled meats, was studied in female Sprague-Dawley rats. The rats were given 10 oral doses of 75 mg AαC from 43 days of age (2 consecutive 5-day periods separated by 2 days) and then placed on a high-fat (23.5% maize oil) diet for up to 50 weeks. By the end of the study period, only 1 of 20 rats had developed a mammary tumour, which was diagnosed histologically as a tubulopapillary carcinoma. No tumour development was found in other major organs. In DNA-adduct studies on rats that were necropsied 3 h after a single or multiple oral doses of 75 mg AαC/kg in maize oil, the total AαC-DNA adduct levels were much higher in liver than in other tissues. One major AαC-DNA adduct was found in mammary gland epithelial cells and other extra-hepatic tissues after single or multiple dosing, and up to 3 minor adducts were also found after multiple dosing. It is suggested that the weak mammary carcinogenicity of AαC may in part be associated with low AαC-DNA adduct levels in mammary gland epithelium.
KW  - amines
KW  - animal models
KW  - biogenic amines
KW  - breast cancer
KW  - carcinogenesis
KW  - carcinogens
KW  - epithelium
KW  - indoles
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - meat products
KW  - neoplasms
KW  - man
KW  - rats
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - cancers
KW  - mammary tumour
KW  - General Physiology (ZZ340) (Discontinued March 2000)
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990401871&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fate of transforming DNA in pathogenic fungi.
AU  - Kwon-Chung, K. J.
AU  - Goldman, W. E.
AU  - Klein, B.
AU  - Szaniszlo, P. J.
A2  - Polonelli, L. O.
A2  - Walsh, T. J.
JO  - Medical Mycology
JF  - Medical Mycology
Y1  - 1998///
VL  - 36
IS  - Suppl. 1
SP  - 38
EP  - 44
AD  - Kwon-Chung, K. J.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202943.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 43 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - genetic transformation
KW  - molecular genetics
KW  - Blastomyces dermatitidis
KW  - Cryptococcus neoformans
KW  - Exophiala dermatitidis
KW  - fungi
KW  - Histoplasma capsulatum
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Blastomyces
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Herpotrichiellaceae
KW  - Chaetothyriales
KW  - Exophiala
KW  - Ajellomyces capsulatus
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - fungus
KW  - Wangiella
KW  - Wangiella dermatitidis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202943&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of vaccines and their use in the prevention of fungal infections.
AU  - Dixon, D. M.
AU  - Casadevall, A.
AU  - Klein, B.
AU  - Mendoza, L.
AU  - Travassos, L.
AU  - Deepe, G. S., Jr.
A2  - Polonelli, L. O.
A2  - Walsh, T. J.
JO  - Medical Mycology
JF  - Medical Mycology
Y1  - 1998///
VL  - 36
IS  - Suppl. 1
SP  - 57
EP  - 67
AD  - Dixon, D. M.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202946.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 90 ref.
KW  - blastomycosis
KW  - cryptococcosis
KW  - disease prevention
KW  - histoplasmosis
KW  - human diseases
KW  - immunization
KW  - mycoses
KW  - paracoccidioidomycosis
KW  - reviews
KW  - vaccination
KW  - Blastomyces dermatitidis
KW  - Cryptococcus neoformans
KW  - Histoplasma capsulatum
KW  - man
KW  - Paracoccidioides brasiliensis
KW  - Pythiaceae
KW  - Pythium
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Blastomyces
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Paracoccidioides
KW  - Pythiaceae
KW  - Pythiales
KW  - Oomycetes
KW  - Oomycota
KW  - Mastigomycotina
KW  - Ajellomyces capsulatus
KW  - european blastomycosis
KW  - fungus
KW  - immune sensitization
KW  - Peronosporomycetes
KW  - pythiosis
KW  - south american blastomycosis
KW  - Straminipila
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202946&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
AU  - Lee, C. G. L.
AU  - Gottesman, M. M.
AU  - Cardarelli, C. O.
AU  - Ramachandra, M.
AU  - Jeang KuanTeh
AU  - Ambudkar, S. V.
AU  - Pastan, I.
AU  - Dey, S.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1998///
VL  - 37
IS  - 11
SP  - 3594
EP  - 3601
SN  - 0006-2960
AD  - Lee, C. G. L.: Laboratory of Cell Biology, Bldg 37, Rm 1A09, National Cancer Institute, HIH, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19982007316.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - The purpose of this study was to determine whether the protease inhibitors ritonavir, saquinavir, and indinavir are recognized by the MDR 1 multidrug transporter (P-glycoprotein, or P-gp), thereby reducing their intracellular accumulation. The results of this study indicate that the HIV-1 protease inhibitors are substrates of the human multidrug transporter, suggesting that cells in patients that express the MDR 1 transporter will be relatively resistant to the antiviral effects of the HIV-1 protease inhibitors, and that absorption, excretion, and distribution of these inhibitors in the body may be affected by the multidrug transporter.
KW  - antiviral agents
KW  - drug resistance
KW  - glycoproteins
KW  - human diseases
KW  - inhibitors
KW  - proteinase inhibitors
KW  - proteinases
KW  - substrates
KW  - treatment
KW  - uptake
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus type 1
KW  - P-glycoprotein
KW  - protease inhibitors
KW  - proteases
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Risk factors and outcome of non-Candida spp. yeasts causing fungaemia in cancer patients: comparison with Candida albicans.
AU  - Krčméry, V., Jr.
AU  - Kunová, A.
AU  - Trupl, J.
T2  - Journal of Hospital Infection
JO  - Journal of Hospital Infection
JF  - Journal of Hospital Infection
Y1  - 1998///
VL  - 38
IS  - 2
SP  - 151
EP  - 154
SN  - 0195-6701
AD  - Krčméry, V., Jr.: Department of Medicine, National Cancer Institute, University of Trnava, School of Public Health, 812 50 Bratislava, Slovakia.
N1  - Accession Number: 19981201427.  Publication Type: Correspondence.  Language: English.  Number of References: 3 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Cases (n=12) of non-Candida yeast fungaemia seen during the last 7 years at the National Cancer Institute, Bratislava, Slovakia, are reported. When azole prophylaxis was started in 1992, only 1 case of non-Candida fungaemia (due to Blastoschizomyces capitatus) was observed within 3 years, the remaining 11 cases appeared within the last 4 years. Six fungaemias were caused by Trichosporon spp., 3 by Cryptococcus laurentii, 1 by Hansenula anomala and 1 by Rhodotorula rubra. Six patients survived and 5 died of fungaemia. The risk factors for the 12 cases included neutropenia, previous antibiotic therapy, prophylaxis with quinolones, infected catheter, acute leukaemia, mucositis and multiple positive blood cultures for yeasts. Comparing 2 groups of fungaemias (non-Candida vs. C. albicans) occurring in the same period at the institute, multiple positive cultures, acute leukaemia, prophylaxis with ofloxacin, prophylaxis with itraconazole and infected catheter were significantly associated with non-Candida spp. aetiology in comparison with 43 C. albicans fungaemias. However, incidence of complications, overall and attributable mortality were similar in both groups.
KW  - blood
KW  - epidemiology
KW  - fungaemia
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - risk factors
KW  - Slovakia
KW  - Candida albicans
KW  - Cryptococcus laurentii
KW  - man
KW  - Pichia anomala
KW  - Rhodotorula mucilaginosa
KW  - Saccharomycetaceae
KW  - Trichosporon
KW  - Trichosporon capitatum
KW  - Blastoschizomyces
KW  - Dipodascaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Hansenula
KW  - Pichiaceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Rhodotorula
KW  - Sporidiobolales
KW  - Microbotryomycetes
KW  - Pucciniomycotina
KW  - Trichosporonaceae
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Trichosporon
KW  - Pichia
KW  - Blastoschizomyces capitatus
KW  - cancers
KW  - fungemia
KW  - fungus
KW  - Hansenula anomala
KW  - Hyphomycetes
KW  - Rhodotorula rubra
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201427&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Cartesian coordinate analysis of viral burden and CD4+ T-cell count in human immunodeficiency virus type-1 infection.
AU  - Reichelderfer, P. S.
AU  - Coombs, R. W.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1998///
VL  - 38
IS  - 3
SP  - 181
EP  - 194
SN  - 0166-3542
AD  - Reichelderfer, P. S.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982012343.  Publication Type: Journal Article.  Language: English.  Number of References: 4 ref. Registry Number: 63231-63-0. 
N2  - A Cartesian coordinate plot was used to analyse the inverse relationship between viral burden (x-axis) and peripheral blood CD4+ cell count (y-axis) to extend our understanding of the mechanisms of antiviral drugs and differences in outcome resulting from variability in virus and host responses. Each of 186 subjects studied were assigned to one of four response quadrants. Quadrants A (x -, y +) and D (x +, y -) defined the effect of a change in virus load on the inverse change in CD4+ cell count expected from the natural history of HIV infection or antiretroviral therapy. Quadrants B (x +, y +) and C (x -, y -) defined the dissociation of the inverse relationship between the relative changes in CD4+ cell count and viral load that resulted from the hypothesized effect of putative virological or immunological response modifiers. Of the response modifiers studied, only the syncytium-inducing phenotype resulted in a complete dissociation of this inverse relationship. The analysis provided an integrated virological and immunological approach to better understand therapeutic responses and potential dissociation between changes in viral RNA and CD4 + cell count. This type of analysis may be helpful for individualizing patient management as well as designing and analysing studies of HIV-1 antiretroviral drugs and disease pathogenesis.
KW  - antiviral agents
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - leukocyte count
KW  - pathogenesis
KW  - phenotypes
KW  - relationships
KW  - RNA
KW  - T lymphocytes
KW  - variation
KW  - viral load
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cell count
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - T cells
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012343&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - N-3 fatty acid deficiency in the rat pineal gland: effects on phospholipid molecular species composition and endogenous levels of melatonin and lipoxygenase products.
AU  - Zhang HongJian
AU  - Hamilton, J. H.
AU  - Salem, N., Jr.
AU  - Kim HeeYong
JO  - Journal of Lipid Research
JF  - Journal of Lipid Research
Y1  - 1998///
VL  - 39
IS  - 7
SP  - 1397
EP  - 1403
SN  - 0022-2275
AD  - Zhang HongJian: Section of Mass Spectrometry, National Institutes of Health, Rockville, MD 20852, USA.
N1  - Accession Number: 19981413086.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 506-32-1, 9029-60-1, 73-31-4.  Subject Subsets: Human Nutrition
N2  - In pineal glands from n-3 fatty acid-deficient Sprague-Dawley rats, an 87% reduction of docosahexaenoic acid was observed, and this decrease was accompanied by increases in docosatetraenoic acid (3-fold), docosapentaenoic acid (12-fold) and arachidonic acid (48%). The significant decrease of docosahexaenoic acid containing species in phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS) was also evident. These decreases in docosahexaenoic acid containing phospholipid species were compensated by substantial accumulations of docosatetraenoic acid or docosapentaenoic acid and slight increases in arachidonic acid containing PL species in PC and PE. In PS, however, the accumulation of n-6 species was not adequate to compensate for the loss of docosahexaenoic acid species. n-3 fatty acid deficiency significantly reduced non-esterified arachidonic acid and docosahexaenoic acid levels in pineal glands (25% and 65%, respectively). Concomitantly, the endogenous 12-HETE level decreased by 35% in deficient pineal glands. In contrast, n-3 deficiency led to a more than 60% increase in the daytime pineal gland melatonin level. It is concluded that n-3 fatty acid deficiency not only has profound effects on pineal gland lipid profiles but also on pineal glandbiochemical activities. This suggests that n-3 fatty acids may play a critical role in regulating pineal gland function.
KW  - arachidonic acid
KW  - composition
KW  - deficiency
KW  - lipoxygenase
KW  - melatonin
KW  - metabolism
KW  - phospholipids
KW  - pineal body
KW  - polyenoic fatty acids
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - eicosatetraenoic acid
KW  - polyunsaturated fatty acids
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981413086&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent trends in tropical medicine research at NIAID/NIH (USA).
AU  - Western, K. A.
JO  - Tropical Medicine (Nagasaki)
JF  - Tropical Medicine (Nagasaki)
Y1  - 1998///
VL  - 40
IS  - 4
SP  - 196
EP  - 197
SN  - 0385-5643
AD  - Western, K. A.: National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), USA.
N1  - Accession Number: 19992010009.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Subject Subsets: Tropical Diseases
N2  - This summarized conference paper briefly identifies major challenges facing tropical medicine and discusses general strategies which the National Institute of Allergy and Infectious Disease (NIAID) is developing to meet these challenges.
KW  - disease control
KW  - human diseases
KW  - medicine
KW  - tropical diseases
KW  - tropical medicine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - medical sciences
KW  - NIAID
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Agencies and Organizations (DD100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.
AU  - Huang, M.
AU  - Maynard, A.
AU  - Turpin, J. A.
AU  - Graham, L.
AU  - Janini, G.
AU  - Covell, D. G.
AU  - Rice, W. G.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1998///
VL  - 41
IS  - 9
SP  - 1371
EP  - 1381
SN  - 0022-2623
AD  - Huang, M.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Bldg 431T-B, P.O. Box B Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982007246.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref. Registry Number: 9007-49-2, 7440-66-6. 
N2  - Agents that target the two highly conserved Zn fingers of HIV nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-coordinating cysteine thiolates of the fingers, causing Zn ejection, loss of native protein structure and nucleic acid binding capacity, and disruption of virus replication. Concentrations of 3 antiviral agents that promoted in vitro Zn ejection from NCp7 and inhibited HIV replication did not impact on the functions of cellular Zn finger proteins, including poly(ADP-ribose) polymerase and Sp1 and GATA-1 transcription factors, nor did the compounds inhibit HeLa nuclear extract-mediated transcription.
KW  - antiviral agents
KW  - binding
KW  - coat proteins
KW  - DNA
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - nucleic acids
KW  - proteins
KW  - replication
KW  - structure
KW  - transcription
KW  - transcription factors
KW  - viral replication
KW  - zinc
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - capsid proteins
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007246&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Maternal diabetes status does not influence energy expenditure or physical activity in 5-year-old Pima Indian children.
AU  - Salbe, A. D.
AU  - Fontvieille, A. M.
AU  - Pettitt, D. J.
AU  - Ravussin, E.
JO  - Diabetologia
JF  - Diabetologia
Y1  - 1998///
VL  - 41
IS  - 10
SP  - 1157
EP  - 1162
SN  - 0012-186X
AD  - Salbe, A. D.: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
N1  - Accession Number: 19991407198.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - The study examined whether maternal diabetes status influences total energy expenditure (TEE by doubly labelled water), resting metabolic rate (RMR by ventilated hood) and physical activity level (PAL = TEE/RMR and assessed by activity questionnaire). Measurements were taken in 88 5-year-old Pima Indian children, 24 children of women with diabetes (2-h plasma glucose ≥11.1 mmol/litre) diagnosed before or during pregnancy and 64 children of women with normal glucose tolerance (2-h plasma glucose &lt; 7.8 mmol/litre during pregnancy and no prior history of abnormal glucose tolerance). Although birth weight was higher in children of diabetic than of nondiabetic women (3.8± 0.6 vs 3.5±0.4 kg, P&lt;0.03), there were no differences in weight (26.4±6.9 vs 24.2±5.6 kg) or percent body fat (18O dilution; 33±8 vs 31±8%) between the groups at 5 years of age. There was no difference in TEE (6508±1109 vs 6175±942 kJ/day) or in RMR (4674±786 vs 4483±603 kJ/day) expressed as absolute values or after adjustment for weight and sex (TEE) or fat-free mass, fat mass, and sex (RMR). Physical activity level was also similar between the groups (1.40±0.12 vs 1.38±0.12). The results suggest that maternal diabetes status does not influence energy expenditure in the children by 5 years of age. Thus the greater obesity seen at older ages in the children of women with diabetes could be due to excess energy intake. Alternatively, if energy expenditure does have a role in the aetiology of obesity in these children, perhaps it does so only in older children.
KW  - birth weight
KW  - body fat
KW  - children
KW  - diabetes
KW  - energy metabolism
KW  - ethnic groups
KW  - glucose tolerance
KW  - physical activity
KW  - pregnancy
KW  - resting energy exchange
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - blood sugar tolerance
KW  - gestation
KW  - Human Reproduction and Development (VV060) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application.
AU  - Howard, O. M. Z.
AU  - Oppenheim, J. J.
AU  - Hollingshead, M. G.
AU  - Covey, J. M.
AU  - Bigelow, J.
AU  - McCormack, J. J.
AU  - Buckheit, R. W. Jr.
AU  - Clanton, D. J.
AU  - Turpin, J. A.
AU  - Rice, W. G.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1998///
VL  - 41
IS  - 13
SP  - 2184
EP  - 2193
SN  - 0022-2623
AD  - Howard, O. M. Z.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Bldg 432 T.-B, P. O. Box B, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982010607.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - This report describes a distamycin analogue, 2,2′-[4,4′-[[aminocarbonyl]amino]bis[N,4′-di[pyrrole-2-carboxamide-1,1′-dimethyl]]-6,8-naphthalenedisulfonic acid]hexasodium salt (NSC 651016), that selectively inhibited chemokine binding to CCR5, CCR3, CCR1, and CXCR4, but not to CXCR2 or CCR2b, and blocked chemokine-induced calcium flux. Inhibition was not due to nonspecific charge interactions at the cell surface, but was based on a specific competition for the ligand receptor interaction sites since the inhibitory effect was specific for some but not all chemoattractant receptors. NSC 651016 inhibited in vitro replication of a wide range of HIV-1 isolates, as well as HIV-2 and SIV, and exhibited in vivo and anti-HIV-1 activity in a murine model.
KW  - antiviral agents
KW  - chemokines
KW  - cytokines
KW  - human diseases
KW  - inhibition
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - distamycin
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010607&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
AU  - Neamati, N.
AU  - Hong HuiXiao
AU  - Owen, J. M.
AU  - Sunder, S.
AU  - Winslow, H. E.
AU  - Christensen, J. L.
AU  - Zhao He
AU  - Burke, T. R. Jr.
AU  - Milne, G. W. A.
AU  - Pommier, Y.
JO  - Journal of Medicinal Chemistry
JF  - Journal of Medicinal Chemistry
Y1  - 1998///
VL  - 41
IS  - 17
SP  - 3202
EP  - 3209
SN  - 0022-2623
AD  - Neamati, N.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19982012165.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9007-49-2. 
N2  - In previous studies N,N′-bis(salicylhydrazine) was identified as a lead compound against purified recombinant HIV-1 integrase. These earlier observations were expanded by the testing of 45 novel hydrazides. Among the compounds tested, 11 derivatives exhibited 50% inhibitory concentrations of less than 3 µM. A common feature for activity among these inhibitors is the hydroxyl group of the salicyl moiety. Although the active inhibitors must contain this hydroxyl group, other structural modifications can also influence potency. Removal of this hydroxyl group or replacement with an amino, bromo, fluoro, carboxylic acid, or ethyl ether totally abolished potency against integrase. Several asymmetric structures exhibited similar potency to the symmetric lead inhibitor 1. The superimposition of the lowest-energy conformations upon one another revealed 3 sites whose properties appear important for lingand binding. Site A is composed of the 2-hydroxyphenyl, the α-keto, and the hydrazine moieties in a planar conformation. It is proposed that this site could interact with HIV-1 integrase by chelation of the metal in the integrase active site as inhibition of HIV-1 integrase catalytic activity and DNA binding were strictly Mn2+-dependent. The hydrophobic sites B and C are probably responsible for complementarity of molecular shape between ligand and receptor. The data indicate that only those compounds which possessed sites A, B, and C in a linear orientation were potent inhibitors of HIV-1 integrase. Although all the active inhibitors possessed considerable cytotoxicity and no apparent antiviral activity in CEM cells, the study presents useful information regarding ligand interaction with HIV-1 integrase protein.
KW  - antiviral agents
KW  - antiviral properties
KW  - binding
KW  - catalytic activity
KW  - cytotoxicity
KW  - derivatives
KW  - DNA
KW  - human diseases
KW  - inhibitors
KW  - integration
KW  - interactions
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - salicylhydrazine
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.
AU  - Turpin, J. A.
AU  - Buckheit, R. W. Jr.
AU  - Derse, D.
AU  - Hollingshead, M.
AU  - Williamson, K.
AU  - Palamone, C.
AU  - Osterling, M. C.
AU  - Hill, S. A.
AU  - Graham, L.
AU  - Schaeffer, C. A.
AU  - Bu Ming
AU  - Huang MingJun
AU  - Cholody, W. M.
AU  - Michejda, C. J.
AU  - Rice, W. G.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 3
SP  - 487
EP  - 494
SN  - 0066-4804
AD  - Turpin, J. A.: Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics Program, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Bldg 431T-B, P.O. Box B, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982004379.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9007-49-2, 9068-38-6, 63231-63-0. 
N2  - Nanomolar concentrations of temacrazine (1,4-bis[6-oxo-6H-v-triazolo[4,5,1-de]acridin-5-yl)amino-propyl]piperazine inhibited acute HIV-1 infections and suppressed the production of virus from chronically and latently infected cells containing integrated proviral DNA. This bistriazoloacridone derivative exerted its mechanism of antiviral action through selective inhibition of HIV-1 transcription during the postintegrative phase of virus replication. Mechanistic studies revealed that temacrazine blocked HIV-1 RNA formation without interference with the transcription of cellular genes or with events associated with the HIV-1 Tat and Rev regulatory proteins. Although temacrazine inhibited the in vitro 3′ processing and strand transfer activities of HIV-1 integrase, with a 50% inhibitory concentration of approximately 50 nM, no evidence of an inhibitory effect on the intracellular integration of proviral DNA into the cellular genome during the early phase of infection could be detected. Furthermore, temacrazine did not interfere with virus attachment or fusion to host cells or the enzymatic activities of HIV-1 reverse transcriptase or protease, and the compound was not directly virucidal. Demonstration of in vivo anti-HIV-1 activity by temacrazine identifies bistriazoloacridones as a new class of pharmaceuticals that selectively blocks HIV-1 transcription.
KW  - antiviral agents
KW  - concentration
KW  - derivatives
KW  - DNA
KW  - drugs
KW  - effects
KW  - genes
KW  - genomes
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - infection
KW  - infections
KW  - inhibition
KW  - interference
KW  - proteinases
KW  - proteins
KW  - replication
KW  - reverse transcriptase
KW  - RNA
KW  - transcription
KW  - treatment
KW  - viral regulatory proteins
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bistriazolacridones
KW  - deoxyribonucleic acid
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - medicines
KW  - pharmaceuticals
KW  - proteases
KW  - ribonucleic acid
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite.
AU  - Rogers, M. J.
AU  - Cundliffe, E.
AU  - McCutchan, T. F.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 3
SP  - 715
EP  - 716
SN  - 0066-4804
AD  - Rogers, M. J.: Growth and Development Section, Laboratory of Parasitic Diseases, Building 4, Room B1-28, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980804556.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Protozoology
N2  - The in vitro antimalarial efficacy of micrococcin was tested against Plasmodium falciparum. This thiopeptide antibiotic was a potent growth inhibitor, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding concentrations of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - efficacy
KW  - growth inhibitors
KW  - in vitro
KW  - mode of action
KW  - novel antiprotozoal agents
KW  - parasites
KW  - protein synthesis
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - micrococcin
KW  - protein biosynthesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804556&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Efficacies of zinc-finger-active drugs against Giardia lamblia.
AU  - Nash, T.
AU  - Rice, W. G.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 6
SP  - 1488
EP  - 1492
SN  - 0066-4804
AD  - Nash, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980807536.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 97-77-8.  Subject Subsets: Protozoology
N2  - Twenty-nine of 34 (85%) zinc-finger-active compounds used at concentrations ≤300 µM inhibited the in vitro growth of Giardia lamblia [G. duodenalis]. The most active compound, disulfiram (Antabuse), was effective at 1.23 ± 0.32 µM. In the adult mouse model, significant in vivo activity of disulfiram (25 mg twice daily for 4 days, administered by gavage as a fine suspension in 200 µl water) was demonstrated by increased cure rates and decreased parasite burdens.
KW  - antiprotozoal agents
KW  - disulfiram
KW  - drug therapy
KW  - efficacy
KW  - experimental infections
KW  - in vitro
KW  - inhibitors
KW  - laboratory animals
KW  - novel antiprotozoal agents
KW  - parasites
KW  - Giardia duodenalis
KW  - mice
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - chemotherapy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807536&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.
AU  - Miyazaki, H.
AU  - Miyazaki, Y.
AU  - Geber, A.
AU  - Parkinson, T.
AU  - Hitchcock, C.
AU  - Falconer, D. J.
AU  - Ward, D. J.
AU  - Marsden, K.
AU  - Bennett, J. E.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 7
SP  - 1695
EP  - 1701
SN  - 0066-4804
AD  - Miyazaki, H.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19981202106.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - Sequential C. glabrata [Torulopsis glabrata] isolates were obtained from the mouth of an HIV-1-infected patient who was receiving high doses of fluconazole (800 mg/day) for oropharyngeal candidosis. Fluconazole-susceptible colonies were replaced by resistant colonies that showed both increased fluconazole efflux and increased transcripts of a gene which coded for a protein with 72.5% identity to Pdr5p, an ABC multidrug transporter in Saccharomyces cerevisiae. The deduced protein had an MW of 175 kDa and was composed of 2 homologous halves, each with 6 putative transmembrane domains and highly conserved sequences of ATP-binding domains. When the earliest and most azole-susceptible isolate of T. glabrata from this patient was exposed to fluconazole, increased transcripts of the PDR5 homologue appeared, linking azole exposure to regulation of this gene.
KW  - antifungal agents
KW  - candidosis
KW  - drug resistance
KW  - drug therapy
KW  - fluconazole
KW  - genes
KW  - infections
KW  - men
KW  - mouth
KW  - Candida glabrata
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Torulopsis
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - candidiasis
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202106&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Safety, tolerance, and pharmacokinetics of a small unilamellar liposomal formulation of amphotericin B (AmBisome) in neutropenic patients.
AU  - Walsh, T. J.
AU  - Yeldandi, V.
AU  - McEvoy, M.
AU  - Gonzalez, C.
AU  - Chanock, S.
AU  - Freifeld, A.
AU  - Seibel, N. I.
AU  - Whitcomb, P. O.
AU  - Jarosinski, P.
AU  - Boswell, G.
AU  - Bekersky, I.
AU  - Alak, A.
AU  - Buell, D.
AU  - Barret, J.
AU  - Wilson, W.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 9
SP  - 2391
EP  - 2398
SN  - 0066-4804
AD  - Walsh, T. J.: Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202598.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety, tolerance and pharmacokinetics of a small unilamellar liposomal formulation of amphotericin B (AmBisome) administered for empirical antifungal therapy were evaluated for 36 persistently febrile neutropenic adults from the USA receiving cancer chemotherapy and bone marrow transplantation. The protocol was an open-label, sequential-dose-escalation, multi-dose pharmacokinetic study which enrolled a total of 8-12 patients in each of the 4 dosage cohorts. Each cohort received daily doses of either 1.0, 2.5, 5.0 or 7.5 mg/kg of amphotericin B in the form of AmBisome. The study population consisted of patients (aged 13-80 years) with neutropenia (absolute neutrophil count &lt;500/mm³) who were eligible to receive empirical antifungal therapy. Patients were monitored for safety and tolerance by frequent laboratory examinations and the monitoring of infusion-related reactions. Efficacy was assessed by monitoring for the development of invasive fungal infection. The pharmacokinetic parameters of AmBisome were measured as those of amphotericin B by HPLC. Noncompartmental methods were used to calculate pharmacokinetic parameters. AmBisome administered as a 1-h infusion in this population was well tolerated and was seldom associated with infusion-related toxicity. Infusion-related side effects occurred in 15 (5%) of all 331 infusions and only 2 patients (5%) required premedication. Serum creatinine, potassium and magnesium levels were not significantly changed from baseline in any of the dosage cohorts, and there was no net increase in serum transaminase levels. AmBisome followed a nonlinear dosage relationship that was consistent with reticuloendothelial uptake and redistribution. There were no breakthrough fungal infections during empirical therapy with AmBisome. It is concluded that AmBisome administered to febrile neutropenic patients in this study was well tolerated, was seldom associated with infusion-related toxicity, was characterized by nonlinear saturation kinetics, and was effective in preventing breakthrough fungal infections.
KW  - amphotericin B
KW  - antifungal agents
KW  - application methods
KW  - drug formulations
KW  - drug therapy
KW  - liposomes
KW  - pharmacokinetics
KW  - safety
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - fungistats
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202598&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antifungal activity of the pradimicin derivative BMS 181184 in the treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits.
AU  - Gonzalez, C. E.
AU  - Groll, A. H.
AU  - Giri, N.
AU  - Shetty, D.
AU  - Al-Mohsen, I.
AU  - Sein, T.
AU  - Feuerstein, E.
AU  - Bacher, J.
AU  - Piscitelli, S.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 9
SP  - 2399
EP  - 2404
SN  - 0066-4804
AD  - Gonzalez, C. E.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202599.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The activity of BMS 181184 was evaluated in a model of invasive pulmonary Aspergillus fumigatus infection in persistently neutropenic rabbits and compared with that of amphotericin B deoxycholate. BMS 181184 at total daily doses of 50 and 150 mg/kg was at least as effective as amphotericin B at 1 mg/kg once daily in conferring survival and had comparable activity in reducing organism-mediated tissue injury and excess lung weight. Although treatment at all dosing regimens of BMS 181184 resulted in significant reductions in fungal tissue burden compared with untreated controls, equivalence to amphotericin B occurred only at the higher dosage level. Similar observations were made in bronchoalveolar lavage fluid cultures obtained postmortem. Monitoring of the animals through ultrafast computerized tomography scan revealed a marked resolution of pulmonary lesions during treatment with BMS 181184. The compound was well tolerated at all dosing regimens and no toxicity was noted. Pharmacokinetic studies revealed nonlinear drug disposition with increased clearance at higher dosages and some evidence for extravascular drug accumulation. It is concluded that BMS 181184 had excellent activity in the treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - aspergillosis
KW  - drug therapy
KW  - efficacy
KW  - experimental infections
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - safety
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - anti-fungal properties
KW  - BMS 181184
KW  - chemotherapy
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - pradimicins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202599&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antifungal efficacy, safety and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits.
AU  - Petraitis, V.
AU  - Petraitiene, R.
AU  - Groll, A. H.
AU  - Bell, A.
AU  - Callender, D. P.
AU  - Sein, T.
AU  - Schaufele, R. L.
AU  - McMillian, C. L.
AU  - Bacher, J.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1998///
VL  - 42
IS  - 11
SP  - 2898
EP  - 2905
SN  - 0066-4804
AD  - Petraitis, V.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981203126.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The antifungal efficacy and safety of LY303366 were investigated in treatment and prophylaxis of primary pulmonary aspergillosis due to Aspergillus fumigatus in persistently neutropenic rabbits. Treatment study groups were either not treated (controls) or treated with amphotericin B (AmB; 1 mg/kg daily) or with LY303366 (at 1, 5, 10, and 20 mg/kg daily). In rabbits treated with LY303366, there was a significant improvement in survival and a reduction in organism-mediated pulmonary injury measured by the number of infarcts, total lung weight and ultrafast computerized tomography scan pulmonary lesion score. Rabbits receiving prophylactic LY303366 also demonstrated significant improvement in survival and reduction in organism-mediated pulmonary injury. AmB and LY303366 had comparable therapeutic efficacies by all parameters with the exception of reduction in tissue burden of A. fumigatus, where AmB was superior to LY303366. LY303366 demonstrated a dose-dependent effect on hyphal injury with progressive truncation, swelling and vacuolization. LY303366 administered in single doses of 1, 5, 10 and 20 mg/kg demonstrated dose-proportional increases in the maximum concentration of drug in plasma and the area under the concentration-time curve from 0 to 72 h with no changes in plasma drug clearance. The 1-mg/kg dosage maintained plasma drug levels above the minimum inhibitory concentration (MIC) for 18 h, and dosages of ≥5 mg/kg maintained plasma drug levels above the MIC for the entire 24-h dosing interval. There was no significant elevation of the concentrations of hepatic transaminases or creatinine in serum in LY303366-treated rabbits. It is concluded that LY303366 improved survival and decreased pulmonary injury with no apparent toxicity in the treatment and prevention of invasive pulmonary aspergillosis in persistently neutropenic rabbits.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - aspergillosis
KW  - drug therapy
KW  - echinocandins
KW  - efficacy
KW  - experimental infections
KW  - lungs
KW  - pharmacokinetics
KW  - safety
KW  - Aspergillus fumigatus
KW  - rabbits
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - anti-fungal properties
KW  - chemotherapy
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - LY303366
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981203126&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Telephone support groups for HIV-positive mothers whose children have died of AIDS.
AU  - Wiener, L. S.
JO  - Social Work
JF  - Social Work
Y1  - 1998///
VL  - 43
IS  - 3
SP  - 279
EP  - 285
AD  - Wiener, L. S.: Pediatric HIV Psychosocial Support Program, National Cancer Institute, NIH, Bethesda, MD, USA.
N1  - Accession Number: 19982007247.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - death
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mothers
KW  - psychosocial aspects
KW  - social services
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007247&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Anxiety and depression among HIV-infected heterosexuals-a report from India.
AU  - Chandra, P. S.
AU  - Ravi, V.
AU  - Desai, A.
AU  - Subbakrishna, D. K.
JO  - Journal of Psychosomatic Research
JF  - Journal of Psychosomatic Research
Y1  - 1998///
VL  - 45
IS  - 5
SP  - 401
EP  - 409
SN  - 0022-3999
AD  - Chandra, P. S.: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, India.
N1  - Accession Number: 19982014213.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref.
N2  - The aim of the study was to study factors related to anxiety, depression, and suicidal ideation among HIV-seropositive heterosexuals soon after being tested for their HIV status for the first time. Anxiety, depression, and suicidal ideation were assessed among 51 HIV-seropositive heterosexual men and women at various stages of HIV infection. All assessments were done between 4 and 6 weeks after revelation of positive serostatus. Psychosocial variables such as quality of family relationships and substance use and sociodemographic details such as gender, income, education, and residence were studied for their association with psychiatric morbidity. Illness details studied for their association with psychiatric morbidity included stage of HIV infection, spouse's HIV status, presence of physical illness, and pain. Depression was present in 40% and anxiety in 36% of the sample. Serious suicidal intent was seen in 14%. Multiple regression analysis indicated that presence of pain, concurrent alcohol abuse, poor family relations, and presence of AIDS in the spouse were significant factors associated with depression, anxiety, and suicidal ideation.
KW  - acquired immune deficiency syndrome
KW  - anxiety
KW  - depression
KW  - families
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - psychosocial aspects
KW  - suicide
KW  - India
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - AIDS
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adhesion of Plasmodium gallinaceum ookinetes to the Aedes aegypti midgut: sites of parasite attachment and morphological changes in the ookinete.
AU  - Zieler, H.
AU  - Garon, C. F.
AU  - Fischer, E. R.
AU  - Shahabuddin, M.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1998///
VL  - 45
IS  - 5
SP  - 512
EP  - 520
SN  - 1066-5234
AD  - Zieler, H.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990801357.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Plasmodium gallinaceum ookinetes adhered to A. aegypti midgut epithelia when purified ookinetes and isolated midguts were combined in vitro. Ookinetes preferentially bound to the microvillated luminal surface of the midgut and appeared to interact with 3 types of structures on the midgut surface. They adhered to and migrated through a network-like matrix, termed the microvilli-associated network, that covers the surface of the microvilli. This network forms on the luminal midgut surface in response to blood or protein meals. The ookinetes also bound directly to the microvilli on the surface of the midgut and were occasionally found immersed in the thick microvillar layer; and ookinetes associated with accumulations of vesicular structures found interspersed between the microvillated cells of the midgut. The origin of these vesicular structures is unknown, but they correlated with the surface of midgut cells invaded by ookinetes as observed by transmission electron microscopy. After binding to the midgut, ookinetes underwent extensive morphological changes: they frequently developed one or more annular constrictions and their surface roughened considerably, suggesting that midgut components remain bound to the parasite surface. The observations suggest that, in a natural infection, the ookinete interacts in a sequential manner with specific components of the midgut surface. Initial binding to the midgut surface may activate the ookinete and cause morphological changes in preparation for invasion of the midgut cells.
KW  - cell invasion
KW  - cells
KW  - cytoadherence
KW  - development
KW  - developmental stages
KW  - epithelium
KW  - host parasite relationships
KW  - in vitro
KW  - microvilli
KW  - midgut
KW  - morphology
KW  - ookinetes
KW  - parasites
KW  - transmission electron microscopy
KW  - ultrastructure
KW  - vesicles
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - cell adhesion
KW  - growth phase
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Contextual determinants of maternal mortality in rural Pakistan.
AU  - Midhet, F.
AU  - Becker, S.
AU  - Berendes, H. W.
JO  - Social Science & Medicine
JF  - Social Science & Medicine
Y1  - 1998///
VL  - 46
IS  - 12
SP  - 1587
EP  - 1598
SN  - 0277-9536
AD  - Midhet, F.: National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B05, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981811250.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Rural Development; Tropical Diseases
N2  - An investigation is presented of the risk factors associated with maternal mortality in 16 rural districts of Baluchistan and the Northwest Frontier (NWFP) provinces of Pakistan. A nested case-control study comprising 261 cases (maternal deaths reported during last five years) and 9135 controls (women who survived a pregnancy during last five years) was designed. Using contextual analysis, the paper estimates the interactions between the biological risk factors of maternal mortality and the district-level indicators of health services. Women under 19 or over 39 yr of age, those having their first birth, and those having a previous history of fetal loss were at greater risk of maternal death. Staffing patterns of peripheral health facilities in the district and accessibility of essential obstetric care (EOC) were significantly associated with maternal mortality. These indicators also modified the effects of the biological risk factors of maternal mortality. For example, nulliparous women living in the under-served districts were at greater risk than those living in the better-served districts. It is concluded that better staffing of peripheral health facilities and improved access to EOC could reduce the risk of maternal mortality among women in rural Baluchistan and the NWFP.
KW  - age
KW  - evaluation
KW  - health services
KW  - maternal mortality
KW  - maternity services
KW  - pregnancy
KW  - risk
KW  - rural development
KW  - women
KW  - Balochistan
KW  - North-West Frontier (Pakistan)
KW  - Pakistan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pakistan
KW  - South Asia
KW  - Asia
KW  - Developing Countries
KW  - Commonwealth of Nations
KW  - Baluchistan
KW  - gestation
KW  - Khyber-Pakhtunkhwa
KW  - North West Frontier Province
KW  - North-West Frontier Province
KW  - NWFP
KW  - Pakistan Northwest Frontier
KW  - Health Services (UU350) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fatigue in HIV-infected men receiving investigational interleukin-2.
AU  - Grady, C.
AU  - Anderson, R.
AU  - Chase, G. A.
JO  - Nursing Research
JF  - Nursing Research
Y1  - 1998///
VL  - 47
IS  - 4
SP  - 227
EP  - 234
AD  - Grady, C.: Department of Clinical Bioethics, W. G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982012087.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 102524-44-7, 85898-30-2. 
N2  - Against a background of fatigue related to HIV infection and its multiple manifestations and treatments, therapy with IL-2 dramatically increases the experience of fatigue. Although this increase is transient and tends to return to baseline by 1 month, during that month the patient's life function and quality may be severely affected.
KW  - adverse effects
KW  - fatigue
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunotherapy
KW  - interleukin 2
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - tiredness
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Detection of JC virus in two African cases of progressive multifocal leukoencephalopathy including identification of JCV type 3 in a Gambian AIDS patient.
AU  - Stoner, G. L.
AU  - Agostini, H. T.
AU  - Ryschkewitsch, C. F.
AU  - Mazló, M.
AU  - Gullotta, F.
AU  - Wamukota, W.
AU  - Lucas, S.
JO  - Journal of Medical Microbiology
JF  - Journal of Medical Microbiology
Y1  - 1998///
VL  - 47
IS  - 8
SP  - 733
EP  - 742
SN  - 0022-2615
AD  - Stoner, G. L.: Laboratory of Experimental Neuropathology, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992000106.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating central nervous system (CNS) infection, affecting mainly oligodendrocytes, but also occasional astrocytes. In the USA, Europe and Asia, PML is caused by the human polyomavirus JC virus (JCV) and in autopsy series occurs in about 4-7% of AIDS patients. In Africa, the prevalence of PML in AIDS patients is uncertain and the causative agent is unknown. This study reports immunocytochemical and PCR confirmation of PML in the CNS of an AIDS patient dying in Uganda, East Africa (case 1). In a Gambian patient infected with HIV-2 who died 3 months after onset of AIDS/PML in Germany (case 2), it was possible to confirm the identity of the virus by DNA sequencing of the PCR amplified JCV product. This African genotype of the virus (type 3) showed an unusual re-arrangement of the regulatory region, and could be distinguished at several sites from East African and African-American JCV strains described previously. This study has confirmed that PML is a complication of African AIDS as it is in Europe and the USA, and that JCV type 3 is pathogenic in African AIDS patients. Furthermore, the finding of an African genotype of JCV in a patient dying in Germany suggests that in this individual JCV represented a latent infection acquired in Africa.
KW  - acquired immune deficiency syndrome
KW  - detection
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - identification
KW  - progressive multifocal leukoencephalopathy
KW  - JC polyomavirus
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - JC virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000106&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-related risk behaviors among psychiatric inpatients in India.
AU  - Chopra, M. P.
AU  - Eranti, S. S. V.
AU  - Chandra, P. S.
JO  - Psychiatric Services
JF  - Psychiatric Services
Y1  - 1998///
VL  - 49
IS  - 6
SP  - 823
EP  - 825
AD  - Chopra, M. P.: Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560 029, India.
N1  - Accession Number: 19982008519.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref.
N2  - This study explored patterns of risk behaviour and knowledge about HIV and AIDS among patients in an inpatient psychiatric facility in south India. 59 consecutive patients admitted to a state psychiatric hospital were interviewed using a semistructured questionnaire. 51% had a history of recent risk behaviour, and 86% had inadequate knowledge about AIDS. The most common high-risk behaviour was unprotected heterosexual intercourse with a high-risk partner. There was no correlation between knowledge and high-risk behaviour. The findings underscore the need to specifically tailor intervention programmes.
KW  - acquired immune deficiency syndrome
KW  - behaviour
KW  - heterosexuality
KW  - HIV infections
KW  - hospitals
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - mental disorders
KW  - patients
KW  - psychiatry
KW  - questionnaires
KW  - risk behaviour
KW  - sexual intercourse
KW  - India
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - AIDS
KW  - behavior
KW  - heterosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - mental illness
KW  - psychiatric disorders
KW  - risk behavior
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008519&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Validity of self-reported fat distribution in young adults: the CARDIA study.
AU  - Bild, D. E.
AU  - Sholinsky, P. D.
AU  - Schreiner, P. J.
AU  - Hilner, J. E.
AU  - Swanson, C. A.
JO  - Journal of Clinical Epidemiology
JF  - Journal of Clinical Epidemiology
Y1  - 1998///
VL  - 51
IS  - 5
SP  - 407
EP  - 413
SN  - 0895-4356
AD  - Bild, D. E.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19981409876.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 57-88-5, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - To determine the validity of self-reported information on body fat distribution, relationships between reported location of weight gain and measured waist-to-hip ratio (WHR), HDL cholesterol (HDL-C) and fasting insulin were analysed in 5115 black and white men and women aged 18-30 years from Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California in the USA. In black men, WHR adjusted for age and body mass index (BMI) ranged from 0.833 among those reporting upper and central weight gain to 0.812 among those reporting lower body weight gain (trend across 5 reported fat distribution categories, P=0.0004). Corresponding values were, for white men, 0.852-0.831; for black women, 0.777-0.721; and for white women, 0.772-0.701 (each P&lt;0.0001). Reported fat distribution was associated with HDL-C in women, but not in men, and with fasting insulin in all groups. It is concluded that while these associations were somewhat weaker than with measured WHR, self-reported fat distribution does provide valid information about body fat distribution in young adults, particularly women.
KW  - anthropometric dimensions
KW  - blood
KW  - blood lipids
KW  - body fat
KW  - body weight
KW  - cholesterol
KW  - distribution
KW  - ethnic groups
KW  - ethnicity
KW  - high density lipoprotein
KW  - insulin
KW  - lipoproteins
KW  - men
KW  - risk factors
KW  - sex differences
KW  - weight gain
KW  - women
KW  - Alabama
KW  - California
KW  - Illinois
KW  - Minnesota
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - East South Central States of USA
KW  - Gulf States of USA
KW  - North America
KW  - OECD Countries
KW  - Southeastern States of USA
KW  - Southern States of USA
KW  - USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - East North Central States of USA
KW  - Lake States of USA
KW  - West North Central States of USA
KW  - anthropometric measurements
KW  - ethnic differences
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981409876&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Play development in children with HIV infection : a pilot study.
AU  - Parks, R. A.
AU  - Oakley, F.
AU  - Fonseca, M.
JO  - American Journal of Occupational Therapy
JF  - American Journal of Occupational Therapy
Y1  - 1998///
VL  - 52
IS  - 8
SP  - 672
EP  - 675
AD  - Parks, R. A.: Rehabilitation Medicine Department, National Institutes of Health, Bldg. 10, Rm 6S-235, 10 Center Drive, MSC 1604, Bethesda, MD 20892-1604, USA.
N1  - Accession Number: 19982013596.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref.
KW  - behaviour
KW  - children
KW  - development
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - paediatrics
KW  - psychosocial aspects
KW  - therapy
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - behavior
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - pediatrics
KW  - therapeutics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013596&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neurocysticercosis - a clinicopathological appraisal.
AU  - Kudesia, S.
AU  - Vani Santosh
AU  - Pal, L.
AU  - Sarala Das
AU  - Shankar, S. K.
JO  - Medical Journal Armed Forces India
JF  - Medical Journal Armed Forces India
Y1  - 1998///
VL  - 54
IS  - 1
SP  - 13
EP  - 18
SN  - 0377-1237
AD  - Kudesia, S.: National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
N1  - Accession Number: 19980805935.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Helminthology; Tropical Diseases
N2  - Between 1977 and 1994, 153 cases of neurocysticercosis were histopathologically diagnosed on surgically resected and autopsied material in Karnataka State, India. Variable numbers of cysts were found, mostly in the cerebral parenchyma (98 cases), followed by the cerebral ventricles (14) and subarachnoid spaces (12). Cysts were rarely located in the cerebellum (8), brain stem (4) or spinal cord (6). Patients harbouring parenchymal cysts manifested predominantly with seizures and encephalitis whereas those with ventricular and/or cisternal cysts presented with features of chronic meningitis and hydrocephalus. Unusual clinical manifestations were psychiatric symptoms with behavioural abnormalities and stroke in the young as a result of cysticercal meningitis with associated arteritis. Primary cysticercal abscess in the brain parenchyma was recorded in 3 cases. In endemic areas, the co-existence of neurocysticercosis appears to enhance morbidity and mortality due to Japanese encephalitis (31 cases).
KW  - brain
KW  - brain diseases
KW  - brain stem
KW  - central nervous system
KW  - cestode infections
KW  - cestode larvae
KW  - clinical aspects
KW  - diagnosis
KW  - helminths
KW  - histopathology
KW  - human diseases
KW  - infections
KW  - Japanese encephalitis
KW  - metacestodes
KW  - mixed infections
KW  - morbidity
KW  - mortality
KW  - nervous system diseases
KW  - neurocysticercosis
KW  - parasites
KW  - pathology
KW  - spinal cord
KW  - India
KW  - Karnataka
KW  - Japanese encephalitis virus
KW  - man
KW  - Taenia solium
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Taenia
KW  - Taeniidae
KW  - Eucestoda
KW  - Cestoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - brain disorders
KW  - cerebrum
KW  - clinical picture
KW  - CNS
KW  - death rate
KW  - multiple infections
KW  - Mysore
KW  - neuropathy
KW  - parasitic worms
KW  - pork tapeworm
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805935&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Towards developing HIV-2 lentivirus based retroviral vectors for gene therapy: dual gene expression in the context of HIV-2 LTR and Tat.
AU  - Sadaie, M. R.
AU  - Zamani, M.
AU  - Whang, S.
AU  - Sistron, N.
AU  - Arya, S. K.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1998///
VL  - 54
IS  - 2
SP  - 118
EP  - 128
SN  - 0146-6615
AD  - Sadaie, M. R.: Basic Research Laqboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bldg. 37, Rm 6C24, Bethesda, MD 20892.
N1  - Accession Number: 19982010685.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
N2  - The expression of genes specifically directed by the HIV-2 LTR and Tat in a prototypic minimal transfer vector was investigated. The expression of a gene in a dual gene configuration depended upon its position in the transcriptional unit and the insertion of an internal translational initiation mechanism improved the expression of the downstream gene. Apparently not sufficiently appreciated previously, these effects were promoter and cell-type dependent. These data also suggest that the commonly used cellular or viral promoters may be orders of magnitude less effective than HIV-2 LTR in the presence of Tat, and thus may not be useful as internal promoters in the context of the HIV-2 LTR:Tat regulatory loop.
KW  - acquired immune deficiency syndrome
KW  - disease vectors
KW  - gene expression
KW  - gene therapy
KW  - human diseases
KW  - promoters
KW  - vectors
KW  - Human immunodeficiency virus 2
KW  - Lentivirus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - AIDS
KW  - human immunodeficiency virus type 2
KW  - promoter region
KW  - promoter sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
AU  - Fidock, D. A.
AU  - Nomura, T.
AU  - Wellems, T. E.
JO  - Molecular Pharmacology
JF  - Molecular Pharmacology
Y1  - 1998///
VL  - 54
IS  - 6
SP  - 1140
EP  - 1147
SN  - 0026-895X
AD  - Fidock, D. A.: Malaria Genetics Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990806002.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 516-21-2, 9002-03-3, 500-92-5.  Subject Subsets: Protozoology
N2  - This paper describes a transformation system, involving selection by the dihydrofolate reductase (DHFR) inhibitor WR99210 of cycloguanil- sensitive or resistant Plasmodium falciparum parasites transformed with either wild-type or methotrexate-resistant human DHFR, that has application for the screening of P. falciparum-specific DHFR inhibitors that are active against drug-resistant parasites. Using this system in vitro, it was found that cycloguanil had a mode of pharmacological action distinct from the activity of its parent compound proguanil. Cycloguanil acted specifically on P. falciparum DHFR and had no other significant target - transformation with human DHFR (which can substitute for its P. falciparum equivalent) gave a very high degree of protection against cycloguanil. In contrast, transformation had very little effect on proguanil susceptibility, indicating that DHFR is not the target of proguanil, and that proguanil acts as an antimalarial in its native form as well as after conversion to cycloguanil. The authors propose a strategy of combination chemotherapy involving the use of multiple parasite-specific inhibitors that act on the same molecular target and maintain, in combination, their effectiveness against alternative forms of resistance that arise from different sets of point mutations in the target.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - cycloguanil
KW  - dihydrofolate reductase
KW  - drug resistance
KW  - drug targets
KW  - in vitro
KW  - inhibitors
KW  - malaria
KW  - mode of action
KW  - parasites
KW  - proguanil
KW  - screening
KW  - techniques
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - chlorguanide
KW  - chloroguanide
KW  - cycloguanil embonate
KW  - screening tests
KW  - tetrahydrofolate dehydrogenase
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protease inhibitors for the treatment of human immunodeficiency virus infection.
AU  - Kakuda, T. N.
AU  - Struble, K. A.
AU  - Piscitelli, S. C.
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
Y1  - 1998///
VL  - 55
IS  - 3
SP  - 233
EP  - 254
AD  - Kakuda, T. N.: Department of Pharmacy, Warren G. Magnuson Clinical Center, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 1N-257, MSC 1196, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982004112.  Publication Type: Journal Article.  Language: English.  Number of References: 127 ref.
N2  - The pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage and administration of protease inhibitors are reviewed.
KW  - adverse effects
KW  - antiviral agents
KW  - drugs
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibitors
KW  - interactions
KW  - pharmacokinetics
KW  - pharmacology
KW  - proteinase inhibitors
KW  - proteinases
KW  - treatment
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - human immunodeficiency virus
KW  - medicines
KW  - pharmaceuticals
KW  - protease inhibitors
KW  - proteases
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004112&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selective depletion of DNA precursors. An evolving strategy for potentiation of dideoxynucleoside activity against human immunodeficiency virus.
AU  - Johns, D. G.
AU  - Gao WenYi
JO  - Biochemical Pharmacology
JF  - Biochemical Pharmacology
Y1  - 1998///
VL  - 55
IS  - 10
SP  - 1551
EP  - 1556
SN  - 0006-2952
AD  - Johns, D. G.: Laboratory of Medicinal Chemistry, Division of Basic Sciences, Bldg. 37, Rm. 5B22, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19982007908.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Registry Number: 69655-05-6, 9007-49-2, 127-07-1, 63231-63-0. 
N2  - Since viral DNA synthesis has an absolute requirement for all 4 deoxynucleoside-5′-triphosphates (dNTPs), restriction of a single one of these is sufficient to inhibit HIV-1 replication. To date, this therapeutic strategy has been most successful when depletion of the individual dNTP is coupled with exposure to its corresponding chain-terminating dideoxynucleoside (ddN). While several examples of such combined therapy have been defined and studied in vitro, that which has been investigated most extensively at both the laboratory and the clinical level is ddATP exposure combined with dATP depletion [with dATP restriction being induced by the ribonucleotide reductase inhibitor hydroxyurea (HU) and ddATP generated from its prodrug 2′,3′-dideoxyinosine (ddI)]. Several long-term clinical trials of the hydroxyurea/2′,3′-dideoxyinosine combination have been completed, with plasma viral RNA being reduced to undetectable levels in a substantial fraction (one third to one half) of the patients treated. The major advantages of this and analogous combinations discussed in this review are their low cost relative to other current multiple drug protocols and their potential for retention of activity against drug-resistant HIV mutants.
KW  - antiviral agents
KW  - clinical trials
KW  - combination therapy
KW  - depletion
KW  - didanosine
KW  - dideoxynucleosides
KW  - DNA
KW  - drug resistance
KW  - genomes
KW  - hosts
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - hydroxycarbamide
KW  - in vitro
KW  - metabolites
KW  - mutants
KW  - precursors
KW  - replication
KW  - reviews
KW  - RNA
KW  - synthesis
KW  - transcription
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - combined modality therapy
KW  - deoxyribonucleic acid
KW  - dideoxyinosine
KW  - DNA transcription
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - hydroxyurea
KW  - multimodal treatment
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007908&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2′,3′-dideoxyinosine.
AU  - Gao WenYi
AU  - Zhou BingSen
AU  - Johns, D. G.
AU  - Mitsuya, H.
AU  - Yen Yun
JO  - Biochemical Pharmacology
JF  - Biochemical Pharmacology
Y1  - 1998///
VL  - 56
IS  - 1
SP  - 105
EP  - 112
SN  - 0006-2952
AD  - Gao WenYi: Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014879.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 69655-05-6, 127-07-1, 9047-64-7, 9068-66-0. 
N2  - The ribonucleotide reductase inhibitor hydroxyurea exhibits potent synergism, even at low, non-cytotoxic concentrations, with the anti-HIV-1 dideoxynucleoside 2′,3′-dideoxyinosine, bringing about failure of HIV DNA synthesis and, thus, of HIV replication. To elucidate the incompletely defined role of hydroxyurea in the hydroxyurea/dideoxyinosine interaction and, in particular, to identify the reasons for the unusual selective inhibitory action of the combination on retroviral rather than on cellular DNA synthesis, specific cDNA probes were prepared to determine the effects of low-level hydroxyurea on mammalian cell ribonucleotide reductase M1 and M2 subunit mRNA, while simultaneously quantitating the effects of the drug on cell cycle and on deoxynucleoside triphosphate pools. While dTTP, dCTP, and dGTP pools changed little or even increased in the presence of low-level hydroxyurea, there took place a rapid and specific inhibition of M2-subunit-catalyzed generation of dATP, with consequent slowing of cellular DNA synthesis and prolongation of S phase. However, the latter effect, in turn, resulted in increased M2 subunit mRNA transcription (a process blocked in G0/G1-phase cells, with full-length functional M2 transcripts being generated only during S phase) and, hence, in a return to normal levels of dATP and to a normal rate of cellular DNA synthesis. Because of this self-regulating mechanism, hydroxyurea-induced host-cell toxicity was obviated under conditions where HIV DNA synthesis, a process sensitive to both dATP depletion and the chain-terminating properties of the other inhibitory component of the combination (ddATP derived from dideoxyinosine), was unable to recover.
KW  - antiviral agents
KW  - didanosine
KW  - dideoxynucleosides
KW  - human immunodeficiency viruses
KW  - hydroxycarbamide
KW  - pharmacodynamics
KW  - regulation
KW  - ribonucleotide reductase
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - dideoxyinosine
KW  - drug action
KW  - human immunodeficiency virus
KW  - hydroxyurea
KW  - mechanism of drug action
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014879&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
AU  - Ciolino, H. P.
AU  - Daschner, P. J.
AU  - Wang, T. T. Y.
AU  - Yeh, G. C.
JO  - Biochemical Pharmacology
JF  - Biochemical Pharmacology
Y1  - 1998///
VL  - 56
IS  - 2
SP  - 197
EP  - 206
SN  - 0006-2952
AD  - Ciolino, H. P.: Cellular Defense and Carcinogenesis Section, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19981413248.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 458-37-7, 9035-51-2.  Subject Subsets: Horticultural Science; Human Nutrition
N2  - We examined the interaction of curcumin, a dietary constituent and Curcumin caused a rapid accumulation of cytochrome P450 1A1 (CYP1A1) mRNA in a time- and concentration-dependent manner, and CYP1A1 monooxygenase activity increased as measured by ethoxyresorufin-O-deethylation. Curcumin activated the DNA-binding capacity of the aryl hydrocarbon receptor (AhR) for the xenobiotic responsive element of CYP1A1 as measured by the electrophoretic-mobility shift assay (EMSA). Curcumin was able to compete with the prototypical AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the AhR in isolated MCF-7 cytosol, indicating that it interacts directly with the receptor. Although curcumin could activate the AhR on its own, it partially inhibited the activation of AhR, as measured by EMSA, and partially decreased the accumulation of CYP1A1 mRNA caused by the mammary carcinogen dimethylbenzanthracene (DMBA). Curcumin competitively inhibited CYP1A1 activity in DMBA-treated cells and in microsomes isolated from DMBA-treated cells. Curcumin also inhibited the metabolic activation of DMBA, as measured by the formation of DMBA-DNA adducts, and decreased DMBA-induced cytotoxicity. It is suggested that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for the AhR and CYP1A1. Curcumin may thus be a natural ligand and substrate of the AhR pathway.
KW  - binding
KW  - cell cultures
KW  - curcumin
KW  - cytochrome P-450
KW  - enzymes
KW  - gene expression
KW  - hydrocarbons
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - prevention
KW  - receptors
KW  - cancers
KW  - mammary tumour
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Food Composition and Quality (QQ500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981413248&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The cloning and characterization of a novel cytochrome P450 family, CYP26, with specificity toward retinoic acid.
AU  - Haque, M.
AU  - Andreola, F.
AU  - DeLuca, L. M.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1998///
VL  - 56
IS  - 3
SP  - 84
EP  - 85
SN  - 0029-6643
AD  - Haque, M.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 19981409786.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Registry Number: 9035-51-2, 302-79-4.  Subject Subsets: Human Nutrition
N2  - Literature is briefly reviewed, describing the cloning and characterization of the CYP26 family of cytochromes in zebra fish, human and mouse tissues and the importance of this development in investigating the relationship between expression of these cytochromes and modulation of disease states, including cancer.
KW  - characterization
KW  - cytochrome P-450
KW  - cytochromes
KW  - enzymes
KW  - human diseases
KW  - neoplasms
KW  - regulation
KW  - retinoic acid
KW  - reviews
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - cloning
KW  - tretinoin
KW  - vitamin A acid
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981409786&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: lessons learned from the Pima Indians.
AU  - Pratley, R. E.
JO  - Proceedings of the Nutrition Society
JF  - Proceedings of the Nutrition Society
Y1  - 1998///
VL  - 57
IS  - 2
SP  - 175
EP  - 181
SN  - 0029-6651
AD  - Pratley, R. E.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19981411714.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - The pathogenesis of type 2 diabetes mellitus in the Pima Indians is reviewed under the following headings: who are the Pima Indians?; what is the evidence that environmental or acquired factors contribute to type 2 diabetes mellitus in Pima Indians?; what is the evidence that genetic factors contribute to the development of type 2 diabetes mellitus in Pima Indians?; Pima Indians as a model population to study the genetics of type 2 diabetes mellitus; studies of the genetics of type 2 diabetes mellitus in Pima Indians; identifying potential diabetogenic genes in Pima Indians; and gene-environment interactions in the pathogenesis of type 2 diabetes mellitus.
KW  - diabetes
KW  - diabetes mellitus
KW  - environmental factors
KW  - ethnic groups
KW  - genetic factors
KW  - pathogenesis
KW  - reviews
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Social Structure (UU480) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981411714&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleas.
AU  - Hinnebusch, B. J.
AU  - Gage, K. L.
AU  - Schwan, T. G.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1998///
VL  - 58
IS  - 5
SP  - 562
EP  - 569
SN  - 0002-9637
AD  - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980504747.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - In the case of bubonic plague, infective flea vectors contain large numbers of Y. pestis within a bacterial mass that blocks the flea's foregut, and only such blocked fleas are important for biological transmission. A bacterial quantitation method could therefore be used to assess the prevalence of plague-infective (blocked) fleas in a population. The authors developed a standard, curve-based, competitive polymerase chain reaction (PCR) procedure to quantitate Y. pestis in individual fleas. The quantitative PCR (Q-PCR) method equalled a colony count reference method in accuracy and precision when evaluated using mock samples and laboratory-infected fleas (Xenopsylla cheopis). The Q-PCR was more reliable than colony count, however, for field-collected fleas (Oropsylla hirsuta) and for blocked fleas collected after their death. In a sample of fleas collected from a prairie dog (Cynomys ludovicianus) colony (in Colorado, USA) in the aftermath of a plague epizootic, 48% were infected but &lt;2% contained numbers of Y. pestis indicative of blockage. The method provides a means to monitor plague epizootics and associated risks of flea-borne transmission to humans, and is applicable to the study of other vector-borne diseases.
KW  - diagnostic techniques
KW  - disease vectors
KW  - ectoparasites
KW  - estimation
KW  - infectivity
KW  - plague
KW  - polymerase chain reaction
KW  - small mammals
KW  - techniques
KW  - wild animals
KW  - zoonoses
KW  - Colorado
KW  - USA
KW  - Cynomys
KW  - Cynomys ludovicianus
KW  - Opisocrostis
KW  - Opisocrostis hirsutus
KW  - Oropsylla
KW  - Siphonaptera
KW  - Xenopsylla cheopis
KW  - Yersinia pestis
KW  - Sciuridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Cynomys
KW  - Ceratophyllidae
KW  - Siphonaptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - Xenopsylla
KW  - Pulicidae
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Opisocrostis
KW  - Oropsylla
KW  - Great Plains States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Mountain States of USA
KW  - Western States of USA
KW  - bacterium
KW  - Oriental rat flea
KW  - Oropsylla hirsuta
KW  - PCR
KW  - United States of America
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504747&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - National Institutes of Health in the tropics.
AU  - Varmus, H. E.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1998///
VL  - 59
IS  - 1
SP  - 24
EP  - 28
SN  - 0002-9637
AD  - Varmus, H. E.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982009417.  Publication Type: Journal Article.  Language: English. 
KW  - health
KW  - health services
KW  - human diseases
KW  - tropical medicine
KW  - tropics
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - tropical countries
KW  - tropical zones
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Health Services (UU350) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009417&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Therapy of viral hepatitis.
AU  - Hoofnagle, J. H.
A2  - Krejs, G. J.
A2  - Ferenci, P.
A2  - Arnold, R.
JO  - Digestion
JF  - Digestion
Y1  - 1998///
VL  - 59
IS  - 5
SP  - 563
EP  - 578
SN  - 0012-2823
AD  - Hoofnagle, J. H.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982013388.  Publication Type: Journal Article.  Language: English.  Number of References: 136 ref. Subject Subsets: Public Health
N2  - This paper reviews the therapy of acute viral hepatitis due to hepatitis viruses A, B and C and chronic viral hepatitis due to hepatitis B virus, hepatitis delta virus and hepatitis C virus.
KW  - acute infections
KW  - chronic infections
KW  - drug therapy
KW  - hepatitis
KW  - hepatitis D
KW  - human diseases
KW  - reviews
KW  - viral hepatitis
KW  - hepatitis A virus
KW  - hepatitis B virus
KW  - hepatitis C virus
KW  - hepatitis delta virus
KW  - man
KW  - Hepatovirus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - Hepacivirus
KW  - Flaviviridae
KW  - Deltavirus
KW  - negative-sense ssRNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - severe infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013388&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Making the connection: perspectives on tropical medicine research in the United States.
AU  - James, S. L.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1998///
VL  - 59
IS  - 6
SP  - 847
EP  - 851
SN  - 0002-9637
AD  - James, S. L.: Parasitology and International Programs Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Bethesda, MD 20852, USA.
N1  - Accession Number: 19992001718.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref.
N2  - This presidential address of the American Society of Tropical Medicine and Hygiene (ASTMH) was to have been delivered at the cancelled 47th annual meeting. The address discusses the connection between tropical disease research and the rest of biomedical science; the connection between ASTMH and its scientific constituency; and the connection between ASTMH and the public constituency.
KW  - history
KW  - human diseases
KW  - hygiene
KW  - research
KW  - tropical medicine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - american society of tropical medicine and hygiene
KW  - presidential address
KW  - studies
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001718&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.
AU  - Dai JinRui
AU  - Hallock, Y. F.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1998///
VL  - 61
IS  - 3
SP  - 351
EP  - 353
SN  - 0163-3864
AD  - Dai JinRui: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Room 121, Building 1052, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19980305869.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants
N2  - Three new oligostilbenes (malibatols A and B, and dibalanocarpol) and one known oligostilbene (balanocarpol) were isolated from the organic extract of the leaves of Hopea malibato. Structural elucidation of these compounds was based on interpretation of their chemical and spectral data. The balanocarpols exhibited very modest HIV-inhibitory activity, while the malibatols were cytotoxic to the host cells (CEM SS) in the antiviral assay.
KW  - antiviral properties
KW  - cells
KW  - chemical structure
KW  - cytotoxicity
KW  - human immunodeficiency viruses
KW  - leaves
KW  - medicinal plants
KW  - phenolic compounds
KW  - stilbenoids
KW  - Hopea
KW  - Dipterocarpaceae
KW  - Theales
KW  - Malvales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Hopea
KW  - anti-viral properties
KW  - drug plants
KW  - Hopea malibato
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Non-wood Forest Products (KK540) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980305869&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pyranocoumarins from tropical species of the genus Calophyllum: a chemotaxonomic study of extracts in the National Cancer Institute Collection.
AU  - McKee, T. C.
AU  - Covington, C. D.
AU  - Fuller, R. W.
AU  - Bokesch, H. R.
AU  - Young, S.
AU  - Cardellina, J. H., II
AU  - Kadushin, M. R.
AU  - Soejarto, D. D.
AU  - Stevens, P. F.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1998///
VL  - 61
IS  - 10
SP  - 1252
EP  - 1256
SN  - 0163-3864
AD  - McKee, T. C.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19980313953.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 9068-38-6.  Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry
N2  - (+)-Calanolide A, a novel dipyranocoumarin from the Malesian tree C. lanigerum var. austrocoriaceum, and a closely related compound, (-)-calanolide B, isolated from C. teysmannii var. inophylloide, are representatives of a distinct class of nonnucleoside HIV [human immunodeficiency virus]-1 specific reverse-transcriptase inhibitors under development as an AIDS [acquired immune deficiency syndrome] chemotherapeutic. NCI repository specimens totalling 315 organic extracts from 31 taxa of Calophyllum were analysed for related pyranocoumarins using a simple TLC system. Of the tested extracts, 127 were classified as 'positive'. Eight of the 31 taxa examined, representing 28 species already described (a seventh or eighth of all the species in this genus), contained prenylated coumarins, suggesting that these compounds, while sometimes abundantly present, are not widespread in the genus. Representative members of the TLC-positive extracts were partitioned between CH2Cl2 and 25% aqueous MeOH; the CH2Cl2-soluble materials were analysed by TLC and 1H NMR to confirm the presence of pyranocoumarins. The anti-HIV activity of the partitioned extracts are also presented. This study suggested that there are several distinctive coumarin chemotaxonomic markers distinguishing species of this genus.
KW  - acquired immune deficiency syndrome
KW  - antiviral plants
KW  - antiviral properties
KW  - chemical structure
KW  - collection
KW  - coumarins
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - neoplasms
KW  - plant extracts
KW  - reverse transcriptase
KW  - species
KW  - tropics
KW  - India
KW  - Pacific Ocean
KW  - Calophyllum
KW  - Human immunodeficiency virus 1
KW  - plants
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Calophyllum
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - oceans
KW  - marine areas
KW  - AIDS
KW  - anti-viral properties
KW  - Calophyllum lanigerum
KW  - Calophyllum lanigerum var. austrocoriaceum
KW  - Calophyllum teysmannii
KW  - Calophyllum teysmannii var. inophylloide
KW  - cancers
KW  - drug plants
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - medicinal herbs
KW  - officinal plants
KW  - tropical countries
KW  - tropical zones
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980313953&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.
AU  - Beutler, J. A.
AU  - Shoemaker, R. H.
AU  - Johnson, T.
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1998///
VL  - 61
IS  - 12
SP  - 1509
EP  - 1512
SN  - 0163-3864
AD  - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19990301972.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Three novel geranyl stilbenes, schweinfurthins A, B and C, were isolated from the Cameroonian plant M. schweinfurthii. Their structures were determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity.
KW  - cell lines
KW  - chemical structure
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - medicinal plants
KW  - neoplasms
KW  - plant composition
KW  - stilbenoids
KW  - Cameroon
KW  - Euphorbiaceae
KW  - Macaranga
KW  - man
KW  - Euphorbiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Euphorbiaceae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Macaranga
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - cancers
KW  - chemical constituents of plants
KW  - drug plants
KW  - Macaranga schweinfurthii
KW  - medicinal herbs
KW  - officinal plants
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Non-wood Forest Products (KK540) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Plant Composition (FF040) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990301972&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Saccharomyces cerevisiae-secreted fusion proteins Pfs25 and Pfs28 elicit potent Plasmodium falciparum transmission-blocking antibodies in mice.
AU  - Gozar, M. M. G.
AU  - Price, V. L.
AU  - Kaslow, D. C.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 1
SP  - 59
EP  - 64
SN  - 0019-9567
AD  - Gozar, M. M. G.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980805320.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 308067-58-5.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Two Plasmodium falciparum sexual-stage surface antigens, Pfs25 and Pfs28, which are candidates for use in transmission-blocking vaccines, were produced as single recombinant fusion proteins. The 39-kDa chimeric proteins, with a C-terminal His6 tag, were secreted by Saccharomyces cerevisiae, using the prepro-α-factor leader sequence to enable them to be secreted by the yeast. Pfs25-28 fusion proteins, when used to vaccinate CAF1 mice, were significantly more potent than Pfs25 or Pfs28 alone in eliciting antibodies that blocked oocyst development in Anopheles freeborni mosquitoes allowed to feed on test sera: complete inhibition of oocyst development in the mosquito midgut was achieved with fewer vaccinations, at a lower dose, and for a longer duration. The longest fusion protein gave the best results. Increased antigen-specific IgG titres and highly significant lymphoproliferative stimulation by Pfs28-containing antigens suggested the presence of an immunodominant helper T-cell epitope in the Pfs28 portion of the fusion proteins. This epitope may be responsible for the enhanced humoral response to both Pfs25 and Pfs28 antigens. Production of the fusion protein was improved 12-fold by making the gene more suitable for expression in yeast; this was done by converting Pfs28 codons to yeast-preferred codons, using a modified ADH2 promoter and incorporating a (Glu-Ala)2 repeat after the Kex2 cleavage site.
KW  - animal diseases
KW  - antibodies
KW  - antigens
KW  - disease vectors
KW  - epitopes
KW  - experimental infections
KW  - human diseases
KW  - IgG
KW  - immune response
KW  - laboratory animals
KW  - laboratory mammals
KW  - malaria
KW  - parasites
KW  - proteins
KW  - recombinant antigens
KW  - recombinant proteins
KW  - recombinant vaccines
KW  - surface antigens
KW  - transmission blocking antibodies
KW  - transmission blocking immunity
KW  - vaccine development
KW  - vector-borne diseases
KW  - Anopheles freeborni
KW  - Culicidae
KW  - Diptera
KW  - mice
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - antigenic determinants
KW  - antigenicity
KW  - fungus
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805320&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans.
AU  - Vázquez, N.
AU  - Walsh, T. J.
AU  - Friedman, D.
AU  - Chanock, S. J.
AU  - Lyman, C. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 1
SP  - 145
EP  - 150
SN  - 0019-9567
AD  - Vázquez, N.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981200602.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The ability of interleukin-15 (IL-15) to enhance superoxide production and antifungal activity of human monocytes was studied. After 18 and 48 h of treatment with IL-15, human elutriated monocytes manifested enhanced superoxide production in response to either phorbol myristate acetate or opsonized C. albicans blastoconidia. Similar results were obtained when monocytes were treated with IL-2, but to a lesser extent. Combination studies with IL-15 and IL-2 showed no additive or synergistic effects. Following incubation of monocytes with IL-15 for 18 h, there was no significant increase in mRNA transcripts for components of the NADPH oxidase complex, p40-phox, p47-phox and gp91-phox, indicating a post-transcriptional modulation of enhanced superoxide production. Antibodies against the γ chain of the IL-2 receptor and, to a lesser extent, against the β chain partially abrogated the IL-15-mediated enhanced superoxide production. Additionally, human monocytes showed enhanced killing activity against C. albicans after 18 h of incubation with IL-15 or IL-2, but this treatment did not enhance the ability of these cells to phagocytose C. albicans. The enhanced fungicidal activity seen after 18 h of treatment was no longer detectable after 48 h of cytokine treatment. Culture supernatants from the IL-15-treated monocytes were assayed for the presence of other pro-inflammatory cytokines. IL-15 treatment did not induce the release of detectable levels of tumour necrosis factor alpha, IL-1β, or IL-12. It is concluded that IL-15 upregulates the microbicidal activity of human monocytes against C. albicans.
KW  - activity
KW  - cytokines
KW  - immune response
KW  - immunology
KW  - immunostimulation
KW  - interleukins
KW  - monocytes
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - fungus
KW  - Hyphomycetes
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200602&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins.
AU  - Hinnebusch, B. J.
AU  - Barbour, A. G.
AU  - Restrepo, B. I.
AU  - Schwan, T. G.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 2
SP  - 432
EP  - 440
SN  - 0019-9567
AD  - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980504149.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia hermsii evades the mammalian immune system by periodically switching expression among members of 2 multigene families that encode immunogenic, antigenically distinct outer surface proteins. The type strain, B. hermsii HS1, has at least 40 complete genes and pseudogenes that participate in this multiphasic antigenic variation. Originally termed vmp (for variable major protein) genes, they have been reclassified as vsp (for variable small protein) and vlp (for variable large protein) genes, based on size and amino acid sequence similarities. To date, antigenic variation in B. hermsii has been studied only in the type strain, HS1. Nucleotide sequence comparisons of 23 B. hermsii HS1 genes revealed 5 distinct groups, the vsp gene family and 4 subfamilies of vlp genes. Polymerase chain reaction was used with family- and subfamily-specific primers, followed by restriction fragment length polymorphism analysis, to compare the vsp and vlp repertoires of HS1 and 7 other B. hermsii isolates from Washington, Idaho and California, USA. This analysis, together with pulsed-field gel electrophoresis genome profiles, revealed that the 8 isolates formed 3 distinct groups, which probably represent clonal lineages. Members of the 3 groups coexisted in the same geographic area, but they could also be isolated across large geographical distances. This population structure may result from immune selection by the host, as has been proposed for other pathogens with polymorphic antigens.
KW  - antigenic variation
KW  - antigens
KW  - comparisons
KW  - geographical variation
KW  - lipoproteins
KW  - molecular genetics
KW  - multigene families
KW  - nucleotide sequences
KW  - polymorphism
KW  - population structure
KW  - relapsing fever
KW  - California
KW  - Idaho
KW  - USA
KW  - Washington
KW  - Borrelia hermsii
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Mountain States of USA
KW  - Pacific Northwest States of USA
KW  - antigenic polymorphism
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - immunogens
KW  - outer surface proteins
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504149&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hemoglobin-induced binding of Candida albicans to the cell-binding domain of fibronectin is independent of the Arg-Gly-Asp sequence.
AU  - Yan, S.
AU  - Rodrigues, R. G.
AU  - Roberts, D. D.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 5
SP  - 1904
EP  - 1909
SN  - 0019-9567
AD  - Yan, S.: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201640.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - When grown in the complex medium Sabouraud broth, C. albicans expressed receptors that bind to several domains of fibronectin (FN). Growth in defined medium supplemented with 0.1% haemoglobin, however, enhanced the binding of FN to a single class of receptors, with a Kd=4.6 × 10-8M. Competitive binding assays using recombinant and proteolytic fragments of FN revealed that the cell-binding domain mediated this interaction. A recombinant 40-kDa fragment of FN consisting of type III repeats 9-13 had an inhibitory activity similar to that of the entire 120-kDa cell-binding domain, indicating that the C-terminal portion of the cell-binding domain contains the binding site. A recombinant 33-kDa fragment of the cell-binding domain and a 33-kDa fragment with the RGD sequence deleted had the same inhibitory activities, demonstrating that the RGD sequence recognized by some mammalian integrins is not required. The addition of haemoglobin to the culture medium also enhanced Candida cell adhesion to immobilized FN and to 120- and 40-kDa fragments of FN but not to the collagen-binding or fibrin I domains. Using ligand protection, a surface protein from C. albicans with an apparent molecular mass of 55 kDa was identified that was protected by both FN and the 40-kDa fragment derived from the cell-binding domain. It is concluded that haemoglobin both induces FN binding and changes the relative affinities of C. albicans for the cell- and collagen-binding domains of FN.
KW  - adhesion
KW  - candidosis
KW  - haemoglobin
KW  - pathogenesis
KW  - proteins
KW  - receptors
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - candidiasis
KW  - fibronectin
KW  - fungus
KW  - hemoglobin
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201640&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation of the third capsule-associated gene, CAP60, required for virulence in Cryptococcus neoformans.
AU  - Chang, Y. C.
AU  - Kwon-Chung, K. J.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 5
SP  - 2230
EP  - 2236
SN  - 0019-9567
AD  - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201645.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - A total of 16 acapsular mutants of C. neoformans induced by 4-nitroquinoline-1-oxide were obtained and the acapsular phenotype of 1 of these mutants was complemented. The cloned gene was designated CAP60 and deletion of this newly described capsule-associated gene resulted in an acapsular phenotype. The proposed 67-kDa Cap60p contains 592 amino acids and appears to have a putative transmembrane domain close to the N terminus. DNA sequence analysis revealed that CAP60 has similarity to CAP59 at the centre portion of its coding regions. Contour-clamped homogeneous electric field blot analysis suggested that these 2 genes are on the same chromosome. CAP60 and CAP59, however, could not be functionally substituted for each other by direct complementation or by domain swap experiments. In addition, CAP60 is closely linked to a gene which is similar to a cellulose growth-specific gene of Agaricus bisporus, CEL1. Immunogold electron microscopy studies of the epitope-tagged CAP60 gene revealed that Cap60p was primarily localized to the nuclear membrane. Animal model studies in mice indicated that CAP60 is essential for virulence. It is concluded that CAP60 is required for both capsule formation and virulence.
KW  - cryptococcosis
KW  - experimental infections
KW  - genes
KW  - pathogenicity
KW  - virulence
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - capsule
KW  - european blastomycosis
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201645&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria.
AU  - Stevenson, B.
AU  - Bono, J. L.
AU  - Schwan, T. G.
AU  - Rosa, P.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 6
SP  - 2648
EP  - 2654
SN  - 0019-9567
AD  - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980506398.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia burgdorferi can contain multiple genes encoding different members of the Erp lipoprotein family. Some arthropod-borne bacteria increase the synthesis of proteins required for transmission or mammalian infection when cultures are shifted from cool, ambient air temperature to a warmer, blood temperature. The authors found that all of the erp genes known to be encoded by infectious isolate B31 were differentially expressed in culture after a change in temperature, with greater amounts of message being produced by bacteria shifted from 23 to 35°C than in those maintained at 23°C. Mice infected with B31 by tick (Ixodes scapularis) bite produced antibodies that recognized each of the Erp proteins within 4 weeks of infection, suggesting that the Erp proteins are produced by the bacteria during the early stages of mammalian infection and may play roles in transmission from ticks to mammals. Several of the B31 Erp proteins were also recognized by antibodies from patients with Lyme disease and may prove to be useful antigens for diagnostic testing or as components of a protective vaccine. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are U72776, U72998, U78764 and AF020657.
KW  - antibodies
KW  - biosynthesis
KW  - disease transmission
KW  - disease vectors
KW  - DNA
KW  - genes
KW  - immune response
KW  - laboratory animals
KW  - Lyme disease
KW  - molecular genetics
KW  - nucleotide sequences
KW  - proteins
KW  - temperature
KW  - Acari
KW  - Arachnida
KW  - Borrelia burgdorferi
KW  - Ixodes scapularis
KW  - man
KW  - mice
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Muridae
KW  - rodents
KW  - bacterium
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - immunity reactions
KW  - immunological reactions
KW  - lyme borreliosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506398&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phase 1 evaluation of Vibrio cholerae O1, serotype Inaba, polysaccharide-cholera toxin conjugates in adult volunteers.
AU  - Gupta, R. K.
AU  - Taylor, D. N.
AU  - Bryla, D. A.
AU  - Robbins, J. B.
AU  - Szu, S. C.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 7
SP  - 3095
EP  - 3099
SN  - 0019-9567
AD  - Gupta, R. K.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2720, USA.
N1  - Accession Number: 19982013325.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Tropical Diseases
N2  - Conjugate vaccines were prepared by binding hydrazine-treated lipopolysaccharide (DeALPS) from Vibrio cholerae O1, serotype Inaba, to cholera toxin (CT) variants CT-1 and CT-2. Volunteers (n=75) in the USA were injected with either 25 µg of DeALPS, alone or as a conjugate, or the licensed cellular vaccine containing 4 × 109 organisms each of serotypes Inaba and Ogawa per ml. No serious adverse reactions were observed. DeALPS alone did not elicit serum LPS or vibriocidal antibodies in mice and only low levels of immunoglobulin M (IgM) anti-LPS in the volunteers. Recipients of the cellular vaccine had the highest IgM anti-LPS levels, but the difference was not statistically significant from that elicited by the conjugates. The conjugates elicited the highest levels of IgG anti-LPS (DeALPS-CT-2 &gt; DeALPS-CT-1 &gt; cellular vaccine). Both conjugates and the cellular vaccine elicited vibriocidal antibodies: after 8 months, recipients of cellular vaccine had the highest geometric mean titre (1249), followed by DeALPS-CT-2 (588) and DeALPS-CT-1 (330). The correlation coefficient between IgG anti-LPS and 2-mercaptoethanol (2-ME)-resistant vibriocidal antibodies was 0.81 (P=0.0004). Convalescent sera from cholera patients in Mexico had a mean vibriocidal titre of 2525 that was removed by treatment with 2-ME. The vibriocidal activities of sera from all vaccine groups and from the patients were absorbed (&gt;75%) by LPS but not by either CT-1 or CT-2. Conjugate-induced IgG vibriocidal antibodies persisted longer than those elicited by the whole-cell vaccine. Both conjugates, but not the cellular vaccine, elicited IgG anti-CT.
KW  - conjugate vaccines
KW  - evaluation
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - polysaccharides
KW  - vaccination
KW  - volunteers
KW  - USA
KW  - man
KW  - Vibrio cholerae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - complex carbohydrates
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013325&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance.
AU  - James, S. L.
AU  - Cheever, A. W.
AU  - Caspar, P.
AU  - Wynn, T. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 8
SP  - 3510
EP  - 3518
SN  - 0019-9567
AD  - James, S. L.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19990804117.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4, 10102-43-9.  Subject Subsets: Helminthology
N2  - Inducible nitric oxide synthase (iNOS)-deficient mice were used to determine the role of nitric oxide (NO) in mice vaccinated with irradiated cercariae of Schistosoma mansoni. ELISA and reverse transcriptase PCR analysis showed that vaccinated iNOS-deficient mice developed exacerbated type 1 cytokine responses in the lungs, the site where resistance to infection is primarily manifested. In addition, parasite-specific IgG2a and IgG2b antibody responses were significantly increased in vaccinated iNOS-deficient animals and total IgE antibody levels in serum were decreased relative to those in wild-type controls. Surprisingly, since resistance in this vaccine model is largely Th1 dependent and since Th1-related cellular and humoral immune responses were found to be exacerbated in vaccinated iNOS-deficient mice, vaccine-elicited protective immunity against challenge infection was found to be reduced. These findings demonstrate that iNOS plays a paradoxical role in immunity to S. mansoni, both in the effector mechanism of resistance and in the down regulation of the type 1 cytokine response, which is ultimately required for NO production.
KW  - cercariae
KW  - cytokines
KW  - experimental infections
KW  - helminths
KW  - IgE
KW  - IgG
KW  - immune response
KW  - immunity
KW  - immunoglobulins
KW  - laboratory animals
KW  - nitric oxide
KW  - parasites
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - gamma-globulins
KW  - immune globulins
KW  - immunity reactions
KW  - immunological reactions
KW  - inducible nitric oxide synthase
KW  - nitric oxide synthase
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Strigeida
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804117&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region.
AU  - Mei, Q.
AU  - Turner, R. E.
AU  - Sorial, V.
AU  - Klivington, D.
AU  - Angus, C. W.
AU  - Kovacs, J. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 9
SP  - 4268
EP  - 4273
SN  - 0019-9567
AD  - Mei, Q.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202585.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Seven major surface glycoprotein (MSG) genes were cloned from a single human isolate of P. carinii by PCR or genomic library screening and were sequenced. The predicted proteins, like rat MSGs, were closely related but unique variants, with a high level of conservation among cysteine residues. A conserved immunodominant region (of approx. 100 amino acids) near the carboxy terminus was expressed at high levels in Escherichia coli and used in Western blot studies. All 49 of the serum samples, which were taken from healthy controls as well as from patients with and without P. carinii pneumonia, were reactive with this peptide by Western blotting, supporting the hypothesis that most adult humans have been infected with P. carinii at some point. It is concluded that this recombinant MSG fragment may be a useful reagent for investigating the epidemiology of P. carinii infection in humans.
KW  - antigens
KW  - gene expression
KW  - genes
KW  - glycoproteins
KW  - human diseases
KW  - mycoses
KW  - pneumocystosis
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - antigenicity
KW  - fungus
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202585&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii.
AU  - Yap, G. S.
AU  - Scharton-Kersten, T.
AU  - Ferguson, D. J. P.
AU  - Howe, D.
AU  - Suzuki, Y.
AU  - Sher, A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 9
SP  - 4382
EP  - 4388
SN  - 0019-9567
AD  - Yap, G. S.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990803339.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Subject Subsets: Protozoology
N2  - The virulent RH strain of Toxoplasma gondii is acutely lethal in mice and fails to establish chronic infection. Vaccination of BALB/c mice with a soluble tachyzoite antigen preparation, STAg, in combination with IL-12 results in partial protection against RH lethal challenge. Nevertheless, brain tissue obtained from surviving, vaccinated mice as late as 1 year after RH infection contained latent parasite forms as demonstrated by subinoculation into naive recipients. The tachyzoites arising in the subinoculated animals were genetically indistinguishable from the original RH inoculum. Microscopic examination revealed that the persistent parasite forms present in the brains of vaccinated and challenged mice have a tissue cyst-like morphology and express the bradyzoite antigen BAG-1 but not the tachyzoite-specific antigen SAG-2, and are different from the cysts formed by avirulent T. gondii strains in that the internal parasite stages display ultrastructural features intermediate between tachyzoites and bradyzoites. Moreover, the zoites within the RH tissue cysts are clearly distinct from conventional bradyzoites in their sensitivity to pepsin-HCl digestion. In contrast to the observations made with partially resistant STAg/IL-12-vaccinated animals, no latent forms could be detected in brain tissue after RH challenge of mice immunized with a live attenuated tachyzoite vaccine which confers total protection against this parasite isolate.
KW  - antigens
KW  - bradyzoites
KW  - cytokines
KW  - experimental infections
KW  - host parasite relationships
KW  - immunization
KW  - interleukin 12
KW  - laboratory animals
KW  - latent infections
KW  - parasites
KW  - tachyzoites
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - antigenicity
KW  - immune sensitization
KW  - immunogens
KW  - parasite host relationships
KW  - soluble tachyzoite antigen
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803339&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages.
AU  - Doherty, T. M.
AU  - Sher, A.
AU  - Vogel, S. N.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1998///
VL  - 66
IS  - 9
SP  - 4553
EP  - 4556
SN  - 0019-9567
AD  - Doherty, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990803346.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9008-11-1, 10102-43-9, 33069-62-4.  Subject Subsets: Protozoology
N2  - The antitumour drug paclitaxel (Taxol) has been shown to be a lipopolysaccharide mimetic in murine macrophages. The capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and γ-interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO.)-dependent mechanism.
KW  - immunology
KW  - immunostimulation
KW  - interferon
KW  - lipopolysaccharides
KW  - macrophages
KW  - nitric oxide
KW  - paclitaxel
KW  - parasites
KW  - Leishmania major
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - taxol
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803346&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: a controlled dietary study.
AU  - Forman, M. R.
AU  - Johnson, E. J.
AU  - Lanza, E.
AU  - Graubard, B. I.
AU  - Beecher, G. R.
AU  - Muesing, R.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1998///
VL  - 67
IS  - 1
SP  - 81
EP  - 87
SN  - 0002-9165
AD  - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 211, 6130 Executive Boulevard MSC 7326, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19981404299.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 432-70-2, 7488-99-5, 7235-40-7, 502-65-8, 127-40-2, 144-68-3.  Subject Subsets: Human Nutrition
N2  - As premenopausal women experience cyclic fluctuations of plasma carotenoids and their lipoprotein carriers, it was hypothesized that carotenoid concentrations in lipoprotein fractions fluctuate by phase of the menstrual cycle. Nine women ate a standard set of carotenoid-rich foods daily for 2 cycles under isoenergetic conditions. In the second cycle, hormones and carotenoids in lipoprotein fractions were measured in the early and late follicular and luteal phases. α-Carotene concentrations in the LDL fraction were lower in the early than in the late follicular phase (P=0.03) on the basis of regression analysis. β-Carotene concentrations in the LDL fraction and the HDL2 subfraction were higher in the late follicular than in the luteal phase (P=0.02 and P=0.04, respectively). Lutein [xanthophyll]/zeaxanthin concentrations in the LDL and HDL fractions were higher in the late follicular than in the luteal phase (P=0.03 and P=0.02, respectively). In each phase, 80% of α-carotene, 82% of β-carotene, 85% of lycopene and 64% of lutein/zeaxanthin were distributed in the LDL fraction. Among the hydrocarbon carotenoids, 18% of α-carotene and of β-carotene and 13% of lycopene were distributed in the HDL fraction, with slightly more in the HDL2 than in the HDL3 subfraction. In contrast 34% of lutein/zeaxanthin was distributed in the HDL fraction with more concentrated in the HDL3 than in the HDL2 subfraction. Less than 4% of any carotenoid was found in the VLDL+IDL (intermediate-density-lipoprotein) fractions. Thus, the hydrocarbon carotenoids were highly concentrated in the LDL fraction and xanthophyll was more evenly distributed in the LDL and HDL fractions. It was concluded that the cyclic fluctuations of these carotenoids in lipoprotein fractions add another dimension to the understanding of their transport and physiologic function.
KW  - alpha-carotene
KW  - beta-carotene
KW  - blood
KW  - carotenoids
KW  - diet
KW  - high density lipoprotein
KW  - lipoproteins
KW  - low density lipoprotein
KW  - lycopene
KW  - menstrual cycle
KW  - nutritional state
KW  - very low density lipoprotein
KW  - vitamins
KW  - women
KW  - xanthophyll
KW  - zeaxanthin
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - lutein
KW  - nutritional status
KW  - tetraterpenoids
KW  - Human Reproduction and Development (VV060) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404299&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study.
AU  - Visser, M.
AU  - Langlois, J.
AU  - Guralnik, J. M.
AU  - Cauley, J. A.
AU  - Kronmal, R. A.
AU  - Robbins, J.
AU  - Williamson, J. D.
AU  - Harris, T. B.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1998///
VL  - 68
IS  - 3
SP  - 584
EP  - 590
SN  - 0002-9165
AD  - Visser, M.: National Institute on Aging, Epidemiology, Demography, and Biometry Program, Gateway Building, Room 3C309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981416487.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
N2  - The relation between body composition (fat mass and fat-free mass, assessed by bioelectrical impedance) and self-reported, mobility-related disability (difficulty walking or stair climbing) was studied in 2714 women and 2095 men aged 65-100 years. Data from the Cardiovascular Health Study was used: an ongoing population based, observational study of 5201 older men and women in California, Maryland, Pennsylvania and North Carolina, USA. In a cross-sectional analysis at baseline (1989-1990), disability was reported by 26.5% of women and 16.9% of men. A positive association was observed between fat mass and disability. The odds ratio for disability in the highest quintile of fat mass was 3.04 (95% CI: 2.18, 4.25) for women and 2.77 (95% CI: 1.82, 4.23) for men compared with those in the lowest quintile. Low fat-free mass was not associated with a higher prevalence of disability. In a longitudinal analysis among persons not reporting disability at baseline, 20.3% of the women and 14.8% of the men reported disability 3 years later. Fat mass at baseline was predictive of disability 3 years later, with odds ratios of 2.83 (95% CI: 1.80, 4.46) for women and 1.72 (95% CI: 1.03, 2.85) for men in the highest quintile of fat. The increased risk was not explained by age, physical activity, chronic disease or other potential confounders. Low fat-free mass was not predictive of disability. It is concluded that a high body fat is an independent predictor of mobility-related disability in older men and women.
KW  - anthropometric dimensions
KW  - body composition
KW  - body fat
KW  - body lean mass
KW  - disabilities
KW  - elderly
KW  - health
KW  - men
KW  - obesity
KW  - old age
KW  - risk factors
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aged
KW  - anthropometric measurements
KW  - elderly people
KW  - fatness
KW  - lean body mass
KW  - older adults
KW  - senior citizens
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981416487&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein.
AU  - Pise-Masison, C. A.
AU  - Choi KyeongSook
AU  - Radonovich, M.
AU  - Dittmer, J.
AU  - Kim SeongJin
AU  - Brady, J. N.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 2
SP  - 1165
EP  - 1170
SN  - 0022-538X
AD  - Pise-Masison, C. A.: Laboratory of Receptor Biology and Gene Expression, Division of Basic Sciences, National Cancer Institute, 41 Library Dr., 41/B403, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982003053.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
N2  - These studies were initiated to analyse whether the stabilized wild-type p53 in HTLV-I-transformed cell lines was transcriptionally active. Data obtained from transfection experiments using a p53-responsive reporter plasmid and from γ-irradiation studies demonstrate that the wild-type p53 in these cell lines is not fully active. Further, it is demonstrated that Tax alone in contransfection studies is capable of inactivating p53 by inhibiting the N-terminal p53 activation domain.
KW  - cell lines
KW  - genes
KW  - growth
KW  - human diseases
KW  - pathogenesis
KW  - regulation
KW  - T lymphocytes
KW  - Tax protein
KW  - transactivation
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - viruses
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - T cells
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003053&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The application of a homologous recombination assay revealed amino acid resides in an LTR-retrotransposon that were critical for integration.
AU  - Atwood, A.
AU  - Choi, J.
AU  - Levin, H. L.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 2
SP  - 1324
EP  - 1333
SN  - 0022-538X
AD  - Atwood, A.: Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982003058.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 9007-49-2. 
N2  - Retroviruses and their relatives, the LTR-retrotransposons, possess an integrase protein (IN) that is required for the insertion of reverse transcripts into the genome of host cells. Schizosaccharomyces pombe is the host of Tfl, an LTR-retrotransposon with integration activity that can be studied by using techniques of yeast genetics. The purpose of this study was to identify amino acid substitutions in Tfl that specifically affected the integration step of transposition. In addition to seeking amino acid substitutions in IN, the possibility was also explored that other Tfl proteins contributed to integration. By comparing the results of genetic assays that monitored both transposition and reverse transcription, it was possible to seek point mutations throughout Tfl that blocked transposition but not the synthesis of reverse transcripts. These mutant versions of Tfl were candidates of elements that possessed defects in the integration step of transposition. Five mutations in Tfl that resulted in low levels of integration were found to be located in the IN protein: two substitutions in the N-terminal Zn domain, two in the catalytic core, and one in the C-terminal domain. These results suggested that each of the three IN domains was required for Tfl transposition. The potential role of these 5 amino acid residues in the function of IN is discussed.
KW  - amino acids
KW  - DNA
KW  - genomes
KW  - hosts
KW  - integration
KW  - mutations
KW  - pathogenesis
KW  - proteins
KW  - recombination
KW  - residues
KW  - reverse transcription
KW  - ribonucleases
KW  - synthesis
KW  - techniques
KW  - transposition
KW  - yeasts
KW  - fungi
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - fungus
KW  - gene transposition
KW  - genetic recombination
KW  - integrase
KW  - RNASE
KW  - RNase H
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003058&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic determinants responsible for acquisition of dengue type 2 virus mouse neurovirulence.
AU  - Bray, M.
AU  - Men, R.
AU  - Tokimatsu, I.
AU  - Lai ChingJuh
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 2
SP  - 1647
EP  - 1651
SN  - 0022-538X
AD  - Bray, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980503811.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Studies conducted some 50 years ago showed that serial intracerebral passage of dengue viruses in mice selected for neurovirulent mutants that also exhibited significant attenuation for humans. The genetic basis of mouse neurovirulence of dengue virus was investigated as it might be directly or indirectly associated with attenuation for humans. Analysis of the sequence in the C-PreM-E-NS1 region of the parental dengue type 2 virus (DEN2) New Guinea C (NGC) strain and its mouse-adapted, neurovirulent mutant revealed that 10 nucleotide changes occurred during serial passage in mice. 7 of these changes resulted in amino acid substitutions, i.e. Leu55-Phe and Arg57-Lys in PreM, Glu71-Asp, Glu126-Lys, Phe402-Ile, and Thr454-Ile in E, and Arg105-Gln in NS1. The sequence of C was fully conserved between the parental and mutant DEN2. Intertypic chimaeric dengue viruses were constructed that contained the PreM-E genes or only the NS1 gene of neurovirulent DEN2 NGC substituting for the corresponding genes of DEN4. The DEN2 (PreM-E)/DEN4 chimaera was neurovirulent for mice, whereas DEN2 (NS1)/DEN4 was not. The mutations present in the neurovirulent DEN2 PreM-E genes were then substituted singly or in combination into the sequence of the nonneurovirulent, parental DEN2. Intracerebral titration of the various mutant chimaeras so produced identified 2 amino acid changes, namely, Glu71-Asp and Glu126-Lys, in DEN2 E as being responsible for mouse neurovirulence. The conservative amino acid change of Glu71-Asp probably had a minor effect, if any. The Glu126-Lys substitution in DEN2 E, representing a change from a negatively charged amino acid to a positively charged amino acid, most probably plays an important role in conferring mouse neurovirulence.
KW  - acquisition
KW  - amino acids
KW  - arboviruses
KW  - chimaeras
KW  - genetics
KW  - virulence
KW  - dengue 2 virus
KW  - dengue virus
KW  - mice
KW  - Dengue virus
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - chimeras
KW  - neurovirulence
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980503811&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1.
AU  - Moriuchi, H.
AU  - Moriuchi, M.
AU  - Fauci, A. S.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 4
SP  - 3394
EP  - 3400
SN  - 0022-538X
AD  - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, BLDG 10, Rm 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005750.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 302-79-4. 
N2  - Although promonocytic cell lines such as U937 have been used as in vitro models of HIV-1 infection of monocyte-macrophages (M/M), these cell lines are susceptible to certain T-cell-tropic (T-tropic) HIV-1 strains but are resistant to M-tropic HIV-1. This study demonstrates that (i) certain U937 clones ("plus" clones), which are susceptible only to T-tropic HIV-1, become highly susceptible to M-tropic HIV-1 upon differentiation with retinoic acid (RA); (ii) other U937 clones ("minus" clones), which are resistant to both T- and M-tropic HIV-1, remain resistant to both viruses; and (iii) RA treatment induces expression of CCR5, a fusion/entry cofactor for M-tropic HIV-1 in both types of U937 clones, and yet enhances the fusogenicity of the plus clones, but not the minus clones, with M-tropic Envs. These results indicate that the major restriction of M-tropic HIV-1 infection in promonocytic cells occurs at the fusion/entry level, that differentiation into macrophage-like phenotypes renders some of these cells highly susceptible to infection with M-tropic HIV-1, and that CD4 and CCR5 may not be the only determinants of fusion/entry of M-tropic HIV-1 in these cells.
KW  - cell fusion
KW  - cofactors
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - macrophages
KW  - pathogenesis
KW  - phenotypes
KW  - retinoic acid
KW  - T lymphocytes
KW  - tropisms
KW  - uptake
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - tretinoin
KW  - vitamin A acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005750&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIVmac251: dependence on route of challenge exposure.
AU  - Benson, J.
AU  - Chougnet, C.
AU  - Robert-Guroff, M.
AU  - Montefiori, D.
AU  - Markham, P.
AU  - Shearer, G.
AU  - Gallo, R. C.
AU  - Cranage, M.
AU  - Paoletti, E.
AU  - Limbach, K.
AU  - Venzon, D.
AU  - Tartaglia, J.
AU  - Franchini, G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 5
SP  - 4170
EP  - 4182
SN  - 0022-538X
AD  - Benson, J.: Basic Research Laboratory, National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm. 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982006954.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref.
N2  - The gag, pol, and env genes of SIVK6W were expressed in the NYVAC vector, a genetically engineered derivative of the vaccinia virus Copenhagen strain that displays a highly attenuated phenotype in humans. In addition, the genes for the α and β chains of interleukin-12 (IL-12), as well as the IL-2 gene, were expressed in separate NYVAC vectors and inoculated intramuscularly, in conjunction with or separate from the NYVAC-SIV vaccine, in 40 macaques. The overall cytotoxic T-lymphocyte (CTL) response was greater, at the expense of proliferative and humoral responses, in animals immunized with NYVAC-SIV and NYVAC-IL-12 than in animals immunized with the NYVAC-SIV vaccine alone. At the end of the immunization regimen, half of the animals were challenged with SIVmac251 by the intravenous route and the other half were exposed to SIVmac251 intrarectally. Significantly, 5 of the 11 vaccinees exposed mucosally to SIVmac251 showed a transient peak of viraemia 1 week after viral challenge and subsequently appeared to clear viral infection. In contrast, all 12 animals inoculated intravenously became infected, but 5 to 6 months after viral challenge, 4 animals were able to control viral expression and appeared to progress to disease more slowly than control animals. Protection did not appear to be associated with any of the measured immunological parameters. Further modulation of immune responses by coadministration of NYVAC-cytokine recombinants did not appear to influence the outcome of viral challenge. The fact that the NYVAC-SIV recombinant vaccine appears to be effective per se in the animal model that best mirrors human AIDS supports the idea that the development of a highly attenuated poxvirus-based vaccine candidate can be a valuable approach to decrease significantly the spread of HIV infection by the mucosal route.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - cytotoxicity
KW  - disease vectors
KW  - genes
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - humoral immunity
KW  - immune response
KW  - immunization
KW  - infection
KW  - infections
KW  - live vaccines
KW  - mucosa
KW  - pathogenicity
KW  - phenotypes
KW  - regimens
KW  - responses
KW  - T lymphocytes
KW  - vaccines
KW  - vectors
KW  - viral diseases
KW  - Macaca
KW  - man
KW  - monkeys
KW  - simian immunodeficiency virus
KW  - vaccinia virus
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - AIDS
KW  - attenuated vaccines
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - mucous membrane
KW  - T cells
KW  - vaccine candidates
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006954&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2pan-p) transform T cells independently of Jak/STAT activation.
AU  - Mulloy, J. C.
AU  - Migone, T. S.
AU  - Ross, T. M.
AU  - Ton, N.
AU  - Green, P. L.
AU  - Leonard, W. J.
AU  - Franchini, G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 5
SP  - 4408
EP  - 4412
SN  - 0022-538X
AD  - Mulloy, J. C.: Basic Research Laboratory, Bldg. 37, Rm 6A09, National Cancer Institute, NIH, 37 Convent Dr., MSC 4255, Bethesda, MD 20892-8394, USA.
N1  - Accession Number: 19982006934.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
KW  - lymphocyte transformation
KW  - pathogenesis
KW  - T lymphocytes
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type II
KW  - monkeys
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - simian T-lymphotropic virus type II
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006934&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates.
AU  - Bazan, H. A.
AU  - Alkhatib, G.
AU  - Broder, C. C.
AU  - Berger, E. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 5
SP  - 4485
EP  - 4491
SN  - 0022-538X
AD  - Bazan, H. A.: Bldg 4, Rm 236, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982006939.  Publication Type: Journal Article.  Language: English.  Number of References: 99 ref.
N2  - Coreceptor usage by Envs from diverse primary HIV-1 isolates was analysed by a vaccinia virus-based expression and assay system. Usage of recombinant CCR5 and CXCR4 correlated closely with fusogenicity toward macrophages and T-cell lines expressing endogenous coreceptors. Recombinant CCR3 was utilized by most primary and T-cell-line-adapted Envs. Endogenous CXCR4 in macrophages was functional as a coreceptor.
KW  - chemokines
KW  - cytokines
KW  - envelope glycoproteins
KW  - glycoproteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - macrophages
KW  - receptors
KW  - T lymphocytes
KW  - uptake
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5Δ32.
AU  - Michael, N. L.
AU  - Nelson, J. E. A.
AU  - Kewalramani, V. N.
AU  - Chang, G.
AU  - O'Brien, S. J.
AU  - Mascola, J. R.
AU  - Volsky, B.
AU  - Louder, M.
AU  - White, G. C. II
AU  - Littman, D. R.
AU  - Swanstrom, R.
AU  - O'Brien, T. R.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 7
SP  - 6040
EP  - 6047
SN  - 0022-538X
AD  - Michael, N. L.: Viral Epidemiology Branch, National Cancer Institute, NIH, EPN 434, 6130 Executive Blvd., Rockville, MD 20852, USA.
N1  - Accession Number: 19982009731.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref.
N2  - Individuals who are homozygous for the 32-bp deletion in the gene coding for the chemokine receptor and major HIV-1 coreceptor CCR5 (CCR5 -/-) lack functional cell surface CCR5 molecules and are relatively resistant to HIV-1 infection. HIV-1 infection in CCR5 -/- individuals although rare, has been increasingly documented. This report shows that the viral quasispecies from one such individual throughout disease is homogenous, T-cell line tropic, and phenotypically syncytium-inducing (SI); exclusively uses CXCR4; and replicates well in CCR5 -/- primary T cells. The recently discovered coreceptors BOB and Bonzo are not used. Although early and persistent SI variants have been described in longitudinal studies, this is the first demonstration of exclusive and persistent CXCR4 usage. With the caveat that the earliest viruses available from this subject were from ~4 years following primary infection, these data suggest that HIV-1 infection can be mediated and persistently maintained by viruses which exclusively utilize CXCR4. The lack of evolution toward the available minor coreceptors in this subject underscores the dominant biological roles of the major coreceptors CCR5 and CXCR4.
KW  - chemokines
KW  - cytokines
KW  - homozygosity
KW  - human diseases
KW  - pathogenesis
KW  - receptors
KW  - syncytia
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009731&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CXCR4 and CCR5 genetic polymorophisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR4-Δ32.
AU  - Cohen, O. J.
AU  - Paolucci, S.
AU  - Bende, S. M.
AU  - Daucher, M.
AU  - Moriuchi, H.
AU  - Mouiuchi, M.
AU  - Cicala, C.
AU  - Devey, R. T. Jr.
AU  - Baird, B.
AU  - Fauci, A. S.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 7
SP  - 6215
EP  - 6217
SN  - 0022-538X
AD  - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, 10 Center Dr., MSC 1876, Gldg. 10, RM. 11B13, Bethesda, MD 20892-1876, USA.
N1  - Accession Number: 19982009724.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref.
N2  - Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of HIV-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to 2 nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.
KW  - chemokines
KW  - cytokines
KW  - disease course
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - mutations
KW  - pathogenesis
KW  - polymorphism
KW  - receptors
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - human immunodeficiency virus
KW  - non-progressors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009724&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells.
AU  - Pise-Masison, C. A.
AU  - Radonovich M.
AU  - Sakaguchi, K.
AU  - Appella, E.
AU  - Brady, J. N.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 8
SP  - 6348
EP  - 6355
SN  - 0022-538X
AD  - Pise-Masison, C. A.: Virus Tumor Biology Section, Laboratory of Receptor Biology and Gene Expression, Bldg. 41/B403, National Cancer Institute, NIH, Bethesda, MD 20892-5055, USA.
N1  - Accession Number: 19982011038.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
KW  - adult T-cell leukaemia
KW  - human diseases
KW  - inactivation
KW  - pathogenesis
KW  - proteins
KW  - T lymphocytes
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - adult T-cell leukemia
KW  - HTLV-BLV group
KW  - oncogenesis
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011038&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms.
AU  - Dittmer, U.
AU  - Brooks, D. M.
AU  - Hasenkrug, K. J.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 8
SP  - 6554
EP  - 6558
SN  - 0022-538X
AD  - Dittmer, U.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH 903 S. 4th St., Hamilton, MT 59840, USA.
N1  - Accession Number: 19982010962.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
N2  - Live-attenuated retroviruses have been shown to be effective retroviral vaccines, but currently little is known regarding the mechanism of protection. In this study Friend murine leukaemia virus (F-MuLv) was used as a model to analyse characteristics of a live-attenuated vaccine in protection against virus-induced disease. Live vaccine virus was found to be necessary for induction of immunity, since inactivated F-MuLV did not induce protection.
KW  - animal models
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunity
KW  - live vaccines
KW  - vaccines
KW  - mice
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - attenuated vaccines
KW  - Friend murine leukaemia virus
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010962&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Critical role for CD4+ T cells in controlling retrovirus replication and spread in persistently infected mice.
AU  - Hasenkrug, K. J.
AU  - Brooks, D. M.
AU  - Dittmer, U.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 8
SP  - 6559
EP  - 6564
SN  - 0022-538X
AD  - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH 903 S. 4th St., Hamilton, MT 59840, USA.
N1  - Accession Number: 19982010963.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
N2  - This report shows that the primary reservoir for persistent Friend virus complex infection in the spleen is a small subset of B cells. In at least half of the mice, replication of virus and spread to other cell types are shown to be controlled by a subpopulation of T cells.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - B lymphocytes
KW  - CD4+ lymphocytes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - leukaemia
KW  - replication
KW  - T lymphocytes
KW  - viral replication
KW  - mice
KW  - Retroviridae
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - B cells
KW  - blood cancer
KW  - CD4+ cells
KW  - Friend murine leukaemia virus
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - leucaemia
KW  - leukemia
KW  - T cells
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010963&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies.
AU  - Ostrowski, M. A.
AU  - Krakauer, D. C.
AU  - Li YueXia
AU  - Justement, S. J.
AU  - Learn, G.
AU  - Ehler, L. A.
AU  - Stanley, S. K.
AU  - Nowak, M.
AU  - Fauci, A. S.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 10
SP  - 7772
EP  - 7784
SN  - 0022-538X
AD  - Ostrowski, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg. 10, Rm. 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982013917.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - This study defines the viral genetic basis for the transient bursts in viraemia after immune activation. Tetanus immunization was associated with dramatic and generally reversible shifts in the composition of plasma viral quasispecies. The viral bursts in most cases reflected a nonspecific increase in viral replication secondary to an expanded pool of susceptible CD4+ T cells. An exception to this was in a patient who harboured viruses of differing tropisms (syncytium inducing and non-syncytium inducing [NSI]). In this situation, immunization appeared to select for the replication of NSI viruses. In 1 of 3 patients, the data suggested that immune activation resulted in the appearance in plasma of virus induced from latently infected cells. These findings illustrate certain mechanisms whereby antigenic stimulation may influence the dynamics of HIV replication, including the relative expression of different viral variants.
KW  - blood plasma
KW  - dynamics
KW  - genetic variation
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunization
KW  - pathogenesis
KW  - phenotypes
KW  - replication
KW  - stimulation
KW  - syncytia
KW  - T lymphocytes
KW  - tetanus
KW  - tropisms
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - human immunodeficiency virus
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - lockjaw
KW  - plasma (blood)
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013917&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.
AU  - Rossio, J. L.
AU  - Esser, M. T.
AU  - Suryanarayana, K.
AU  - Schneider, D. K.
AU  - Bess, J. W. Jr.
AU  - Vasquez, G. M.
AU  - Wiltrout, T. A.
AU  - Chertova, E.
AU  - Grimes, M. K.
AU  - Sattentau, Q.
AU  - Arthur, L. O.
AU  - Henderson, L. E.
AU  - Lifson, J. D.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 10
SP  - 7992
EP  - 8001
SN  - 0022-538X
AD  - Rossio, J. L.: Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Bldg 535, Rm 510, Frederick, MD 21702, USA.
N1  - Accession Number: 19982013928.  Publication Type: Journal Article.  Language: English.  Number of References: 66 ref. Registry Number: 50-00-0, 7440-66-6. 
N2  - HIV-1 virions whose infectivity was abrogated were examined by the use of prototypical nucleocapsid zinc finger targeting compound, 2,2′-dithiopyridine (aldrithiol-2 [AT-2]). The analysis focused on assays intended to assess the conformational and functional integrity of virion surface proteins, comparing AT-2-inactivated virus to native virus and to virions inactivated by classical means such as heat treatment or formaldehyde fixation. The findings indicate that the surface proteins of AT-2-treated virus are conformationally and functionally intact, but the virions are not infectious, with the block to infectivity occurring after virion binding and membrane fusion but before reverse transcription.
KW  - antigens
KW  - antiviral properties
KW  - conformation
KW  - formaldehyde
KW  - heat treatment
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inactivation
KW  - infectivity
KW  - nucleocapsid proteins
KW  - proteins
KW  - structure
KW  - surface proteins
KW  - transcription
KW  - treatment
KW  - vaccines
KW  - zinc
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - antigenicity
KW  - body conformation
KW  - DNA transcription
KW  - heat processing
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - membrane proteins
KW  - virions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013928&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of a mucosal cytotoxic T-lymphocyte response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing human immunodeficiency virus 89.6 envelope protein.
AU  - Belyakov, I. M.
AU  - Wyatt, L. S.
AU  - Ahlers, J. D.
AU  - Earl, P.
AU  - Pendleton, C. D.
AU  - Kelsall, B. L.
AU  - Strober, W.
AU  - Moss, B.
AU  - Berzofsky, J. A.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 10
SP  - 8264
EP  - 8272
SN  - 0022-538X
AD  - Belyakov, I. M.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Bldg 10, Rm 6B-12 (MSC #1578), NIH, Bethesda, MD 20892-1578, USA.
N1  - Accession Number: 19982013935.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 308079-78-9. 
N2  - To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. In this study, MVA was applied to HIV-1 vaccine development by incorporating the envelope protein gp160 of HIV-1 primary isolate strain 89.6 (MVA 89.6) and using it to induce mucosal cytotoxic-T-lymphocyte (CTL) immunity. Once the CTL specificity was defined, BALB/c mice were immunized intrarectally with recombinant MVA 89.6. A single mucosal immunization with MVA 89.6 elicited long-lasting antigen-specific mucosal (Peyer's patch and lamina propria) and systemic (spleen) CTL responses as effective as or more effective than those of a replication-competent vaccinia virus expressing 98.6 gp160. Immunization with MVA89.6 led to (i) the loading of antigen-presenting cells in vivo, as measured by the ex vivo active presentation of the P18-89.6 peptide to an antigen-specific CTL line, and (ii) the significant production of the proinflammatory cytokines (interleukin-6 and tumour necrosis factor alpha) in the mucosal sites. These results indicate that nonreplicating recombinant MVA may be at least as effective for mucosal immunization as replicating recombinant vaccinia virus.
KW  - cytokines
KW  - cytotoxicity
KW  - development
KW  - envelope protein gp160
KW  - envelope proteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunity
KW  - immunization
KW  - interleukin 6
KW  - modification
KW  - mucosa
KW  - necrosis
KW  - replication
KW  - safety
KW  - spleen
KW  - T lymphocytes
KW  - tumour necrosis factor
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - man
KW  - mice
KW  - vaccinia virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - cachectin
KW  - cachexin
KW  - gp160
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - mucous membrane
KW  - T cells
KW  - tumor necrosis factor
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013935&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.
AU  - Mulloy, J. C.
AU  - Kislyakova, T.
AU  - Cereseto, A.
AU  - Casereto, L.
AU  - LoMonico, A.
AU  - Fullen, J.
AU  - Lorenzi, M. V.
AU  - Cara, A.
AU  - Nicot, C.
AU  - Giam, C. Z.
AU  - Franchini, G.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 11
SP  - 8852
EP  - 8860
SN  - 0022-538X
AD  - Mulloy, J. C.: Basic Research Laboratory, National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm 6A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014310.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
N2  - Transient coexpression of p53 and Tax resulted in the suppression of p53 transcriptional activity. Expression of Tax abrogated p53-induced G1 arrest in the Calu-6 cell line and prevented the apoptosis induced by overexpressing p53 in the HeLa/Tat cell line.
KW  - apoptosis
KW  - cell cycle
KW  - genes
KW  - human diseases
KW  - pathogenesis
KW  - Tax protein
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014310&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells.
AU  - Mochizuki, H.
AU  - Schwartz, J. P.
AU  - Tanaka, K.
AU  - Brady, R. O.
AU  - Reiser, J.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 11
SP  - 8873
EP  - 8883
SN  - 0022-538X
AD  - Mochizuki, H.: National Institutes of Health, Bldg 10, Rm 3D04, 10 Center Dr., MSC 1260, Bethesda, MD 20892-1260, USA.
N1  - Accession Number: 19982014311.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref.
KW  - gene therapy
KW  - human diseases
KW  - vectors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014311&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic and experimental evidence for cross-species infection by swine hepatitis E virus.
AU  - Meng XiangJin
AU  - Halbur, P. G.
AU  - Shapiro, M. S.
AU  - Sugantha Govindarajan
AU  - Bruna, J. D.
AU  - Mushahwar, I. K.
AU  - Purcell, R. H.
AU  - Emerson, S. U.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 12
SP  - 9714
EP  - 9721
SN  - 0022-538X
AD  - Meng XiangJin: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992200277.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2  - The infectivity titre of a pool of swine hepatitis E virus (HEV) in pigs was measured to prepare a standardized reagent and to evaluate the dose response in pigs. Although the sequence of swine HEV varied extensively from those of most human strains of HEV, it was very closely related to the 2 strains of human HEV (US-1 and US-2) isolated in the United States. The US strains which were recently recovered from 2 patients with clinical hepatitis E in the United States shared ≥97% amino acid identity with swine HEV in open reading frames 1 and 2. Phylogenetic analyses of different regions of the genome showed that swine HEV and the US strains grouped together and formed a distinct branch. These results suggested that swine HEV may infect man. Rhesus monkeys and a chimpanzee, inoculated with swine HEV became infected. Furthermore, in a reciprocal experiment, SPF pigs were experimentally infected with the US-2 strain of human HEV that is genetically similar to swine HEV. These results provided experimental evidence for cross-species infection by the swine virus. Thus, man appears to be at risk of infection with swine HEV or closely related viruses.
KW  - experimental infection
KW  - strain differences
KW  - zoonoses
KW  - USA
KW  - Hepadnaviridae
KW  - hepatitis E virus
KW  - man
KW  - pigs
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Hepatitis E-like viruses
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Sus scrofa
KW  - Sus
KW  - Suidae
KW  - Suiformes
KW  - Artiodactyla
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - experimental transmission
KW  - hogs
KW  - swine
KW  - United States of America
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992200277&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection.
AU  - Monaco, M. C. G.
AU  - Jensen, P. N.
AU  - Hou, J.
AU  - Durham, L. C.
AU  - Major, E. O.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1998///
VL  - 72
IS  - 12
SP  - 9918
EP  - 9923
SN  - 0022-538X
AD  - Monaco, M. C. G.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA.
N1  - Accession Number: 19992001629.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 9007-49-2.  Subject Subsets: Public Health
N2  - To determine whether tonsils harbour JC virus (JCV), 54 tonsils - 38 from children and 16 from adult donors - were tested for JCV DNA using nested PCRs with primer sets specific for the viral T protein and regulatory regions. JCV DNA was detected in 21 of 54 tonsil tissues, or 39% (15 of 38 children and 6 of 16 adults) by using regulatory-region primers and in 19 of 54 tonsil tissues, or 35% (13 of 38 children and 6 of 16 adults) by using the T-protein primers. The DNA extracted from children's non-dissected tonsil tissue, isolated tonsillar lymphocytes, and isolated stromal cells that demonstrated PCR amplification of the JCV regulatory region underwent cloning and nucleotide sequencing. Of the regulatory-region sequences obtained, nearly all contained tandem repeat arrangements. Clones originating from non-dissected tonsil tissue and tonsillar lymphocytes were found to have sequences predominantly of the Mad-1 prototype strain, whereas the majority of clones from the DNA of tonsillar stromal cells had sequences characteristic of the Mad-8br strain of JCV. A few clones demonstrated structures other than tandem repeats but were isolated only from tonsillar lymphocytes. It is concluded that these data provide the first evidence of the JCV genome in tonsil tissue and suggest that tonsils may serve as an initial site of viral infection.
KW  - adults
KW  - children
KW  - detection
KW  - DNA
KW  - human diseases
KW  - pathology
KW  - progressive multifocal leukoencephalopathy
KW  - tonsils
KW  - JC polyomavirus
KW  - man
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - deoxyribonucleic acid
KW  - JC virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001629&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rising incidence of biliary tract cancers in Shanghai, China.
AU  - Hsing, A. W.
AU  - Gao YuTang
AU  - Devesa, S. S.
AU  - Jin, F.
AU  - Fraumeni, J. F., Jr.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1998///
VL  - 75
IS  - 3
SP  - 368
EP  - 370
SN  - 0020-7136
AD  - Hsing, A. W.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19992005740.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref.
N2  - During 1972-1994, biliary tract cancer was the most rapidly rising malignancy in Shanghai, China, with a 119% increase in men and 124% in women. The increase in incidence was seen for all 3 subsites, both sexes, and all age groups.
KW  - biliary system
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - malignant course
KW  - men
KW  - neoplasms
KW  - women
KW  - China
KW  - Shanghai
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - Eastern China
KW  - China
KW  - cancers
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005740&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary habits and stomach cancer in Shanghai, China.
AU  - Ji BuTian
AU  - Chow WongHo
AU  - Yang Gong
AU  - McLaughlin, J. K.
AU  - Zheng Wei
AU  - Shu XiaoOu
AU  - Jin Fan
AU  - Gao RuNie
AU  - Gao YuTang
AU  - Fraumeni, J. F., Jr.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1998///
VL  - 76
IS  - 5
SP  - 659
EP  - 664
SN  - 0020-7136
AD  - Ji BuTian: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981416991.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - To clarify risk factors for stomach cancer a population-based case-control study was conducted in Shanghai, China. 1124 stomach cancer patients (20-69 years old) who were newly diagnosed between 1988 and 1989 and 1451 controls randomly selected from among Shanghai residents were recruited. Usual adult dietary intake was assessed using a comprehensive food frequency questionnaire. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models. Risks of stomach cancer were inversely associated with high consumption of several food groups, including fresh vegetables and fruits, poultry, eggs, plant oil and some nutrients, such as protein, fat, fibre and antioxidant vitamins. By contrast, risks increased with increasing consumption of dietary carbohydrates, with OR of 1.5 (95% CI 1.1-2.1) and 1.9 (95% CI 1.3-2.9) in the highest quartile of intake among men (P=0.02) and women (P=0.0007), respectively. Similar increases in risk were associated with frequent intake of noodles and bread in men (P=0.07) and women (P=0.05) after further adjustment for fibre consumption. In addition, increased risks were associated with frequent consumption of preserved, salty or fried foods and hot soup/porridge and with irregular meals, speed eating and binge eating. No major differences in risk were seen according to subsite (cardia vs. non-cardia). It was concluded that these results suggest that diet plays a major role in stomach cancer risk.
KW  - antioxidants
KW  - carbohydrates
KW  - diet
KW  - diet studies
KW  - eggs
KW  - fat
KW  - feeding habits
KW  - fibre
KW  - fruit
KW  - neoplasms
KW  - plant oils
KW  - poultry meat
KW  - protein
KW  - risk
KW  - risk factors
KW  - stomach
KW  - vegetables
KW  - vitamins
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancers
KW  - eating habits
KW  - fiber
KW  - People's Republic of China
KW  - saccharides
KW  - vegetable crops
KW  - vegetable oils
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981416991&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk factors for colorectal cancer in a prospective study among U.S. white men.
AU  - Hsing, A. W.
AU  - McLaughlin, J. K.
AU  - Chow WongHo
AU  - Schuman, L. M.
AU  - Co Chien, H. T.
AU  - Gridley, G.
AU  - Bjelke, E.
AU  - Wacholder, S.
AU  - Blot, W. J.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1998///
VL  - 77
IS  - 4
SP  - 549
EP  - 553
SN  - 0020-7136
AD  - Hsing, A. W.: Division of Cancer Epidmeiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19991400203.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
N2  - Associations of diet, smoking/drinking and occupation with subsequent risk of fatal colorectal cancer was examined in a cohort of 17 633 white men from the USA aged 35 and older, who completed a postal questionnaire in 1966. During the subsequent 20 years of follow-up, 120 colon cancer and 25 rectal cancer deaths were identified. Due to small numbers, no significant dose-response trends were observed in the study, but the risk of colon cancer was increased among heavy cigarette smokers (≥30/day; relative risk (RR) = 2.3, 95% confidence interval (CI) 0.9-5.7), heavy beer drinkers (≥14 times/month; RR = 1.9, 95% CI 1.0-3.8) and white-collar workers (RR = 1.7, 95% CI 1.0-3.0) or crafts workers within service and trade industries (RR = 2.6, 95% CI 1.1-5.8). In addition, an increased risk was seen for those who consumed red meat more than twice a day (RR = 1.8, 95% CI 0.8-4.4). Risk patterns for cancers of the colon and rectum combined were similar to those reported for cancer of the colon, but the estimates were somewhat dampened. It was concluded that a high intake of red meat and a sedentary life-style may increase the risk of colon cancer.
KW  - alcoholic beverages
KW  - colon
KW  - diet
KW  - meat
KW  - men
KW  - neoplasms
KW  - occupations
KW  - physical activity
KW  - rectum
KW  - risk
KW  - risk factors
KW  - tobacco smoking
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400203&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Aspergillus nidulans infection in chronic granulomatous disease.
AU  - Segal, B. H.
AU  - DeCarlo, E. S.
AU  - Kwon-Chung, K. J.
AU  - Malech, H. L.
AU  - Gallin, J. I.
AU  - Holland, S. M.
JO  - Medicine (Baltimore)
JF  - Medicine (Baltimore)
Y1  - 1998///
VL  - 77
IS  - 5
SP  - 345
EP  - 354
SN  - 0025-7974
AD  - Segal, B. H.: Laboratory of Host Defenses and Molecular Microbiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19991202315.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 1397-89-3. 
N2  - All cases in which A. nidulans was isolated from patients at the National Institutes of Health (Bethesda, MD, USA) during 1976-97 were reviewed. A. nidulans infection occurred in 6 patients with chronic granulomatous disease (CGD), but was not a pathogen in any other patient group. Aspergillus fumigatus was a more common pathogen in CGD compared with A. nidulans, but A. nidulans was more virulent. A. nidulans was significantly more likely to result in death compared with A. fumigatus, to involve adjacent bone and to cause disseminated disease. Patients with A. nidulans received longer courses of amphotericin B therapy than patients with A. fumigatus, and were treated with surgery more often. In contrast to A. fumigatus, A. nidulans was generally refractory to intensive antifungal therapy, suggesting that early surgery may be important. It is concluded that A. nidulans is a distinct pathogen in CGD and its isolation carries more severe implications than that of A. fumigatus.
KW  - amphotericin B
KW  - antifungal agents
KW  - aspergillosis
KW  - epidemiology
KW  - generalized infections
KW  - human diseases
KW  - infections
KW  - pathogenicity
KW  - prognosis
KW  - surgery
KW  - virulence
KW  - USA
KW  - Aspergillus fumigatus
KW  - Emericella nidulans
KW  - man
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Emericella
KW  - Aspergillus nidulans
KW  - chronic granulomatous disease
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202315&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression of human herpesvirus-8 oncogene and cytokine homologues in an HIV-seronegative patient with multicentric Castleman's disease and primary effusion lymphoma.
AU  - Teruya-Feldstein, J.
AU  - Zauber, P.
AU  - Setsuda, J. E.
AU  - Berman, E. L.
AU  - Sorbara, L.
AU  - Raffeld, M.
AU  - Tosato, G.
AU  - Jaffe, E. S.
JO  - Laboratory Investigation
JF  - Laboratory Investigation
Y1  - 1998///
VL  - 78
IS  - 12
SP  - 1637
EP  - 1642
SN  - 0023-6837
AD  - Teruya-Feldstein, J.: Laboratory of Pathology, Hematopathology Section, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19992006799.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
N2  - A rare case of human herpesvirus-8 (HHV-8) associated multicentric Castleman's disease (MCD), followed by the development of an HHV-8-positive pleural primary effusion lymphoma (PEL) and a gastric large cell lymphoma in an HIV-seronegative male patient is described. The lesions were negative for Epstein-Barr virus (EBV). The combination of these diverse HHV-8-associated lymphoproliferative disorders in a single patient afforded the ability to study potential differences in gene expression in these conditions. HHV-8 DNA was demonstrated by PCR in lymphoid tissues involved by MCD and PEL. By reverse transcriptase-PCR, HHV-8-related transcripts, including vG-coupled protein receptor, vbcl2, vcyclin D, vIL-6, vMIPI, and vMIPII, were detected in the PEL from the pleural cavity and the gastric lymphoma, whereas these transcripts, except for vIL-6, were not detected in a lymph node biopsy with MCD. Expression of hIL-10 was weak in the PEL from the pleural cavity, and expression of hIL-6 was undetectable in all three lesions. These data suggest that vIL-6 may be integral to the pathogenesis of MCD, whereas other viral transcripts that encode oncogene and chemokine homologues are important for HHV-8 tumourigenicity.
KW  - case reports
KW  - gene expression
KW  - human diseases
KW  - lymphatic diseases
KW  - lymphoma
KW  - Herpesviridae
KW  - human herpesvirus 8
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Castleman's disease
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006799&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pima Indian males have lower β-adrenergic sensitivity than Caucasian males.
AU  - Tataranni, P. A.
AU  - Christin, L.
AU  - Snitker, S.
AU  - Paolisso, G.
AU  - Ravussin, E.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1998///
VL  - 83
IS  - 4
SP  - 1260
EP  - 1263
SN  - 0021-972X
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19981410551.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - β-Adrenergic sensitivity was examined in 87 nondiabetic normotensive individuals (52 Pima Indians (35 men/17 women) and 35 Caucasians (24 men/11 women)), matched for age and body weight. Chronotropic sensitivity to β-adrenergic stimulation was assessed by the dose of isoproterenol necessary to increase heart rate by 25 beats/min (chronotropic dose-25 (CD25)). Despite a similar basal heart rate and arterial blood pressure, Pimas tended to have lower β-adrenergic sensitivity than Caucasians (CD25 = 2.37±2.27 vs. 1.57±1.38 µg, respectively; P=0.07). This difference was significant in men (CD25 = 3.03±2.39 vs. 1.85±1.56 µg; P=0.02) but not in women (CD25 = 1.01±1.17 vs. 0.96±0.61 µg; P=0.99). In men, CD25 was positively correlated to percentage body fat (r = 0.36, P&lt;0.01). After adjustment for percentage body fat, β-adrenergic sensitivity was still significantly lower in Pima than in Caucasian men (CD25 = 3.44±2.24 vs. 2.57±1.60 µg; P=0.05). It was concluded that increased adiposity is accompanied by decreased β-adrenergic sensitivity in men only. However, at each level of adiposity, Pima Indian men had lower β-adrenergic sensitivity than Caucasian men. In combination with a low sympathetic nervous system activity, a reduced β-adrenergic sensitivity may contribute to the low prevalence of hypertension and the high prevalence of obesity observed in Pima Indians.
KW  - beta-adrenergic receptors
KW  - ethnic groups
KW  - heart rate
KW  - hypertension
KW  - men
KW  - obesity
KW  - sex differences
KW  - sympathetic nervous system
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - high blood pressure
KW  - United States of America
KW  - Social Structure (UU480) (Discontinued March 2000)
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Progress in improving diet to reduce cancer risk.
AU  - Krebs-Smith, S. M.
JO  - Cancer
JF  - Cancer
Y1  - 1998///
VL  - 83
IS  - 7
SP  - 1425
EP  - 1432
SN  - 0008-543X
AD  - Krebs-Smith, S. M.: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19991404620.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Human Nutrition
N2  - In an effort to decrease cancer risk among the population, US national health objectives for the year 2000 included recommendations to decrease intake of dietary fat and alcohol and increase intake of fruits, vegetables, and grains. National food supply data and food consumption survey data from 1970-95 were reviewed for their appropriateness for monitoring intake trends. Recent data from both sources are described and interpreted. Americans have made modest but important improvements in their diets in recent years and may meet the "Healthy People 2000" dietary objectives aimed at decreasing cancer risk. Intake of fruits, vegetables, and grains are higher, and those of fat and alcohol are lower than they were at the beginning of the decade. These trends are consistent with recent improvements in mortality rates for those cancer sites with the strongest associations with diet: the colon/rectum, prostate, and breast. Although the average intake of fruits, vegetables, and grain products is higher, it should be noted that the objective represents the minimum recommendations. Within each of these major food groups, further improvements can be made. Special efforts should be made to guide children toward improvements in their diets and to monitor the diets of children and other subgroups.
KW  - alcoholic beverages
KW  - breast
KW  - children
KW  - colon
KW  - diet
KW  - diet studies
KW  - fats
KW  - fibre
KW  - fruit
KW  - men
KW  - neoplasms
KW  - nutrition education
KW  - nutrition programmes
KW  - old age
KW  - prevention
KW  - prostate
KW  - rectum
KW  - vegetables
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - breasts
KW  - cancers
KW  - feeding programmes
KW  - feeding programs
KW  - fiber
KW  - food programs
KW  - nutrition programs
KW  - United States of America
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404620&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians.
AU  - Baier, L. J.
AU  - Dobberfuhl, A. M.
AU  - Pratley, R. E.
AU  - Hanson, R. L.
AU  - Bogardus, C.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1998///
VL  - 83
IS  - 8
SP  - 2993
EP  - 2996
SN  - 0021-972X
AD  - Baier, L. J.: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016.
N1  - Accession Number: 19981415672.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 1406-16-2.  Subject Subsets: Human Nutrition
N2  - Electrophoretic variants of the vitamin D-binding protein (DBP) have been associated with type 2 diabetes as well as with metabolic characteristics that predispose to type 2 diabetes in several populations. The Gc gene that encodes DBP maps to chromosome 4q12, a region that has been found to be potentially linked to plasma glucose and insulin concentrations in Pima Indians. Therefore, the gene that encodes DBP was analyzed as a candidate gene for the authors' linkage findings in the Pima Indians. Sequence analysis of the coding exons identified 2 previously described missense polymorphisms at codons 416 and 420, which are the genetic basis for the 3 common electrophoretic variants of DBP (Gc1f, Gc1s and Gc2). These variants in DBP were associated with differences in oral glucose tolerance in nondiabetic Pima Indians.
KW  - binding proteins
KW  - ethnic groups
KW  - genetic variation
KW  - glucose tolerance
KW  - vitamin D
KW  - vitamins
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood sugar tolerance
KW  - carrier proteins
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415672&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - In situ lipolytic responses to isoproterenol and physiological stressors are similar in obese Pima Indians and Caucasians.
AU  - Snitker, S.
AU  - Hellmér, J., Jr.
AU  - Boschmann, M.
AU  - Odeleye, O. E.
AU  - Monroe, M. B.
AU  - Young, J. B.
AU  - Ravussin, E.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1998///
VL  - 83
IS  - 11
SP  - 4054
EP  - 4058
SN  - 0021-972X
AD  - Snitker, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19991400188.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 56-81-5, 299-95-6, 51-30-9, 6700-39-6, 76853-59-2.  Subject Subsets: Human Nutrition
N2  - The lipolytic response to adrenergic stimulation was tested in Pima Indians, a population prone to obesity and type 2 diabetes mellitus, to determine if it is lower than in Caucasians. 48 healthy, non-diabetic subjects were studied: 27 Pima Indians (12 males and 15 females, 30±7 years, 85±18 kg, 36±10% body fat) and 21 Caucasians (11 males and 10 females, 34±7 years, 105±26 kg, 39±11% body fat). Lipolysis in the abdominal subcutaneous adipose tissue was assessed in situ by glycerol concentration in microdialysis samples at baseline and during local infusion of the non-selective β-adrenergic agonist isoproterenol (10-6 mol/litre), mental stress and submaximal exercise. The baseline dialysate glycerol concentrations were similar in Pima Indians and Caucasians. Lipolytic response (relative increment in dialysate glycerol concentration, percentage above the baseline) was similar in Pima Indians and Caucasians in response to local isoproterenol infusion (77±36 and 76±40%) and exercise (38±38 and 41±41%). During mental stress, the dialysate concentration did not change significantly from baseline in either group. Changes in local blood flow, determined by ethanol dilution, did not differ between the 2 groups. In conclusion, the high propensity for obesity in Pima Indians does not seem to be due to an impaired lipolytic response to stimuli.
KW  - adrenergic innervation
KW  - beta-adrenergic agonists
KW  - ethnicity
KW  - exercise
KW  - glycerol
KW  - haemodynamics
KW  - isoprenaline
KW  - lipid metabolism
KW  - lipids
KW  - lipolysis
KW  - mental stress
KW  - obesity
KW  - Arizona
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mountain States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southwestern States of USA
KW  - ethnic differences
KW  - fat metabolism
KW  - fatness
KW  - glycerin
KW  - glycerine
KW  - hemodynamics
KW  - isoproterenol
KW  - lipins
KW  - psychological stress
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400188&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium inui is not closely related to other quartan Plasmodium species.
AU  - Kissinger, J. C.
AU  - Collins, W. E.
AU  - Li Jun
AU  - McCutchan, T. F.
JO  - Journal of Parasitology
JF  - Journal of Parasitology
Y1  - 1998///
VL  - 84
IS  - 2
SP  - 278
EP  - 282
SN  - 0022-3395
AD  - Kissinger, J. C.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980807836.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Protozoology
N2  - Plasmodium inui is a malarial parasite of Old World monkeys that occurs in isolated pockets throughout the Celebes, Indonesia, Malaysia and the Philippines and has traditionally been considered to be more closely related to P. malariae of humans (and its primate counterpart P. brasilianum), than to other primate Plasmodium species. This inference was made partly because of similarities in the periodicities or duration of the asexual cycle in the blood, the extended sporogonic cycle and the longer period of time for development of the pre-erythrocytic stages in the liver. Both P. inui and P. malariae have quartan (72 h) periodicities associated with their asexual cycle, whereas other primate malarias, such as P. fragile and P. cynomolgi, are associated with tertian periodicities (48 h) and P. knowlesi, with a quotidian (24 h) periodicity. Phylogenetic analyses of portions of orthologous small subunit ribosomal genes revealed that P. inui is actually more closely related to Plasmodium species of the "vivax-type" lineage than to P. malariae. Ribosomal sequence analysis of 18 different, geographically isolated, antigenically distinct P. inui isolates revealed that they are nearly identical in sequence and therefore represent the same species.
KW  - development
KW  - genes
KW  - life cycle
KW  - malaria
KW  - molecular taxonomy
KW  - nucleotide sequences
KW  - parasites
KW  - periodicity
KW  - phylogeny
KW  - ribosomal RNA
KW  - species
KW  - taxonomy
KW  - Indonesia
KW  - Malaysia
KW  - Philippines
KW  - monkeys
KW  - Plasmodium
KW  - Plasmodium brasilianum
KW  - Plasmodium cynomolgi
KW  - Plasmodium fragile
KW  - Plasmodium inui
KW  - Plasmodium knowlesi
KW  - Plasmodium malariae
KW  - Plasmodium vivax
KW  - Primates
KW  - protozoa
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Plasmodium
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - Commonwealth of Nations
KW  - Threshold Countries
KW  - DNA sequences
KW  - rRNA
KW  - systematics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - Plasmodium gallinaceum: fluorescent staining of zygotes and ookinetes to study malaria parasites in mosquito.
AU  - Mohammed Shahabuddin
AU  - Gayle, M.
AU  - Zieler, H.
AU  - Laughinghouse, A.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 88
IS  - 2
SP  - 79
EP  - 84
SN  - 0014-4894
AD  - Mohammed Shahabuddin: Medial Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980806469.  Publication Type: Journal Article.  Corporate Author: Shahabuddin, M. Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - A fluorescent labelling method is described which can be used to stain the mosquito stages of Plasmodium. PKH26 was efficiently incorporated into the membranes of P. gallinaceum zygotes and ookinetes. Stained zygotes underwent normal development into ookinetes, and the stain did not affect ookinete mobility or ability to adhere to the luminal surface of the midgut of Aedes aegypti.
KW  - fluorescent dyes
KW  - ookinetes
KW  - parasites
KW  - staining
KW  - stains
KW  - techniques
KW  - zygotes
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806469&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: differential killing of some mosquito stages of the parasite by insect defensin.
AU  - Shahabuddin, M.
AU  - Fields, I.
AU  - Bulet, P.
AU  - Hoffmann, J. A.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 89
IS  - 1
SP  - 103
EP  - 112
SN  - 0014-4894
AD  - Shahabuddin, M.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990500056.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - The action of defensins from an evolutionarily ancient insect (Aeshna cyanea) and a recent insect (Phormia terraenovae) were compared. Plasmodium gallinaceum zygotes were incubated in 250 µM solutions of the antibacterial peptides, Phormia defensin, Aeschna defensin, metalnikowin, thanatin, drosocin and metchnikowin. Development of zygotes to ookinetes showed that the peptides are not toxic to zygotes or developing ookinetes. When tested on mature ookinetes, none of the peptides affected the zygotes or ookinetes of P. gallinaceum. Aeschna defensin was found not to affect the transformation of mature ookinetes to oocysts. Under standard conditions it took ~8-9 days for the parasite to develop into a mature oocyst and 10-12 days to release sporozoites for invasion of the salivary glands. When Aedes aegypti were injected with defensin, oocysts appeared to be abnormal if treated 5, 6 or 7 days post blood-meal.The density of abnormal oocytes increased from 4 to 7 days post injection. The minimum amount of insect defensin required to produce abnormal oocysts was 2.5 µM. When treated with antibacterial peptides, only Aeschna and Phormia defensin-treated sporozoites were damaged. When compared Aeschna defensin was found to act more rapidly on gram-positive bacteria than Phormia defensin. It is thought that the defensins act by altering the membrane permeability of oocysts.
KW  - antibacterial agents
KW  - defensins
KW  - developmental stages
KW  - disease vectors
KW  - host parasite relationships
KW  - in vitro
KW  - mosquito-borne diseases
KW  - parasites
KW  - peptides
KW  - toxicity
KW  - Aedes aegypti
KW  - Aeshna cyanea
KW  - Culicidae
KW  - Diptera
KW  - Phormia terraenovae
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Aeshna
KW  - Aeshnidae
KW  - Odonata
KW  - Phormia
KW  - Calliphoridae
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - blackbottle
KW  - drosocin
KW  - growth phase
KW  - metalnikowin
KW  - metchnikowin
KW  - mosquitoes
KW  - parasite host relationships
KW  - thanatin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmania: amastigotes synthesize conserved secretory acid phosphatase during human infection.
AU  - Ellis, S. L.
AU  - Shakarian, A. M.
AU  - Dwyer, D. M.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 89
IS  - 2
SP  - 161
EP  - 168
SN  - 0014-4894
AD  - Ellis, S. L.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980808694.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 9001-77-8.  Subject Subsets: Protozoology
N2  - Sera from patients with acute Leishmania infections (L. donovani, L. tropica, L. major, L. mexicana, L. braziliensis) were tested for anti-soluble acid phosphatase (SAcPs) antibodies using L. donovani promastigote culture supernatants. Sera from patients with visceral leishmaniasis from different endemic foci (Brazil, India, Kenya, Sudan) and also from patients with various forms of cutaneous leishmaniasis were shown to produce antibodies against SAcPs, indicating that Leishmania amastigotes produce SAcPs during infections in man.
KW  - acid phosphatase
KW  - amastigotes
KW  - antibodies
KW  - biochemistry
KW  - cutaneous leishmaniasis
KW  - human diseases
KW  - parasites
KW  - visceral leishmaniasis
KW  - Brazil
KW  - India
KW  - Kenya
KW  - Sudan
KW  - Leishmania
KW  - Leishmania braziliensis
KW  - Leishmania donovani
KW  - Leishmania major
KW  - Leishmania mexicana
KW  - Leishmania tropica
KW  - man
KW  - protozoa
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Commonwealth of Nations
KW  - South Asia
KW  - Asia
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - acid phosphomonoesterase
KW  - secretory proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase.
AU  - Ribeiro, J. M. C.
AU  - Mather, T. N.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 89
IS  - 2
SP  - 213
EP  - 221
SN  - 0014-4894
AD  - Ribeiro, J. M. C.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bulding 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990500181.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 1407-47-2, 58-82-2, 7440-48-4, 7439-96-5.  Subject Subsets: Medical & Veterinary Entomology
N2  - The authors show that tick kininase activity behaves as a metalloenzyme that removes two amino acids at a time from bradykinin up to fragment 1-5, with fragment 1-7 appearing transiently. Tick kininase was purified from I. scapularis by HPLC. Incubation of kininase with bradykinin produced time-dependent disappearance of the bradykinin peak. The activity of the kininase was shown to be significantly enhanced by the manganese and cobalt. The tick salivary kininase was shown to have properties in common with angiotensin-converting enzyme although after a 3 h incubation with angiotensin I, &lt;10% was hydrolysed demonstrating a specificity for bradykinin. Insufficient pure enzyme was obtained for amino acid sequencing.
KW  - angiotensin
KW  - bradykinin
KW  - cobalt
KW  - dipeptidyl carboxypeptidases
KW  - enzyme activity
KW  - enzymes
KW  - hydrolases
KW  - manganese
KW  - metalloproteinases
KW  - saliva
KW  - Acari
KW  - Arachnida
KW  - Ixodes scapularis
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Ixodes
KW  - Ixodidae
KW  - Metastigmata
KW  - Acari
KW  - kininases
KW  - Mn
KW  - salivary secretions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium falciparum: parasite typing by using a multicopy microsatellite marker, PfRRM.
AU  - Su XinZhuan
AU  - Carucci, D. J.
AU  - Wellems, T. E.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 89
IS  - 2
SP  - 262
EP  - 265
SN  - 0014-4894
AD  - Su XinZhuan: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20982-0425, USA.
N1  - Accession Number: 19980808705.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology
N2  - Microsatellite PfRRM fingerprinting of 16 field isolates of Plasmodium falciparum is described. Multiple bands were seen for all parasite DNAs, and each parasite had a unique band pattern. PfRRM was also used to type and verify the identity of four 3D7 clones maintained in different laboratories. Labelling the PCR product with [F]dUTP avoided the use of radioactive materials, and allowed the use of an automatic DNA sequencer.
KW  - clones
KW  - DNA fingerprinting
KW  - identification
KW  - molecular genetics
KW  - parasites
KW  - polymerase chain reaction
KW  - strains
KW  - techniques
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Leishmania tropica: the identification and purification of metacyclic promastigotes and use in establishing mouse and hamster models of cutaneous and visceral disease.
AU  - Lira, R.
AU  - Méndez, S.
AU  - Carrera, L.
AU  - Jaffe, C.
AU  - Neva, F.
AU  - Sacks, D.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 89
IS  - 3
SP  - 331
EP  - 342
SN  - 0014-4894
AD  - Lira, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980808764.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Protozoology
N2  - The use of anti-lipophosphoglycan monoclonal antibodies for the purification of Leishmania tropica metacyclic promastigotes from axenic culture is described. A non-healing, non-progressive form of cutaneous leishmaniasis was reproducibly established in BALB/c mice using these metacyclic promastigotes. Differences in disease progression were found in mice and hamster models using metacyclic promastigotes purified from cutaneous, visceral and viscerotropic (Desert Storm) isolates. A role for parasite-related determinants in the clinical spectrum of disease is suggested.
KW  - clinical aspects
KW  - cutaneous leishmaniasis
KW  - disease models
KW  - experimental infections
KW  - host parasite relationships
KW  - identification
KW  - laboratory animals
KW  - lipophosphoglycans
KW  - monoclonal antibodies
KW  - parasites
KW  - promastigotes
KW  - purification
KW  - techniques
KW  - visceral leishmaniasis
KW  - hamsters
KW  - Leishmania tropica
KW  - mice
KW  - protozoa
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - clinical picture
KW  - metacyclic promastigotes
KW  - parasite host relationships
KW  - viscerotropic leishmaniasis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808764&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Long-term feeding of sodium saccharin to nonhuman primates: Implications for urinary tract cancer.
AU  - Takayama, S.
AU  - Sieber, S. M.
AU  - Adamson, R. H.
AU  - Thorgeirsson, U. P.
AU  - Dalgard, D. W.
AU  - Arnold, L. L.
AU  - Cano, M.
AU  - Eklund, S.
AU  - Cohen, S. M.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1998///
VL  - 90
IS  - 1
SP  - 19
EP  - 25
SN  - 0027-8874
AD  - Takayama, S.: Division of Basic Sciences, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981408514.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 81-07-2.  Subject Subsets: Human Nutrition
N2  - Twenty monkeys of 3 species (6 African green, 7 rhesus, 6 cynomolgus, and one hybrid (of rhesus male and cynomolgus female parentage)) were given sodium saccharin in the diet 25 mg/kg body weight daily for 5 days per week, beginning within 24 h after birth and continuing for up to 24 years. Sixteen monkeys (7 rhesus and 9 cynomolgus) served as controls. During their last 2 years of life, urine was collected from selected treated and control animals and evaluated for various urinary chemistries and for the presence of calculi, microcrystalluria and precipitate. Urinary bladders were examined by light microscopy and by scanning electron microscopy. Sodium saccharin treatment had no effect on the urine or urothelium in any of these monkeys. There was no evidence of increased urothelial cell proliferation, and there was no evidence of formation of solid material in the urine. Although the dose of sodium saccharin administered to these monkeys was only 5-10 times the allowable daily intake for man, the results provide additional evidence that sodium saccharin is without a carcinogenic effect on the primate urinary tract.
KW  - artificial sweeteners
KW  - bladder
KW  - carcinogenesis
KW  - neoplasms
KW  - renal calculi
KW  - saccharin
KW  - species differences
KW  - sweeteners
KW  - urinary tract
KW  - urine
KW  - monkeys
KW  - Primates
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - kidney calculi
KW  - kidney stones
KW  - urinary bladder
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia.
AU  - Chow WongHo
AU  - Blot, W. J.
AU  - Vaughan, T. L.
AU  - Risch, H. A.
AU  - Gammon, M. D.
AU  - Stanford, J. L.
AU  - Dubrow, R.
AU  - Schoenberg, J. B.
AU  - Mayne, S. T.
AU  - Farrow, D. C.
AU  - Habibul Ahsan
AU  - West, A. B.
AU  - Rotterdam, H.
AU  - Niwa, S.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1998///
VL  - 90
IS  - 2
SP  - 150
EP  - 155
SN  - 0027-8874
AD  - Chow WongHo: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981408512.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
N2  - Anthropometric risk factors were examined in a population-based case-control study of oesophageal and gastric cancers in Connecticut, New Jersey, and western Washington, USA. Healthy control subjects (n=695) and case patients with oesophageal squamous cell carcinoma or noncardia gastric adenocarcinoma (n=589) were frequency-matched to case patients with adenocarcinomas of oesophagus or gastric cardia (n=554) by 5-year age groups, sex, and race (New Jersey only). Classification of cases by tumour site of origin and histology was determined by review of pathology materials and hospital records. Data were collected using in-person structured interviews. Associations with obesity, measured by body mass index (BMI), were estimated by odds ratios (ORs). All ORs were adjusted for geographic location, age, sex, race, cigarette smoking, and proxy response status. The ORs for oesophageal adenocarcinoma increased with increasing adult BMI. The magnitude of association with BMI was greater among the younger age groups and among nonsmokers. The ORs for gastric cardia adenocarcinoma rose moderately with increasing BMI. Adult BMI was not associated with risk of oesophageal squamous cell carcinoma or noncardia gastric adenocarcinoma. Increasing prevalence of obesity in the US population may have contributed to the upward trends in oesophageal and gastric cardia adenocarcinomas.
KW  - adenocarcinoma
KW  - age
KW  - anthropometric dimensions
KW  - body weight
KW  - carcinoma
KW  - neoplasms
KW  - obesity
KW  - oesophageal diseases
KW  - oesophagus
KW  - risk factors
KW  - stomach
KW  - tobacco smoking
KW  - Connecticut
KW  - New Jersey
KW  - USA
KW  - Washington
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Middle Atlantic States of USA
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - anthropometric measurements
KW  - cancers
KW  - esophageal diseases
KW  - esophagus
KW  - fatness
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum: use of antisera to degenerate synthetic peptides derived from the active site of protozoal chitinases to characterize an ookinete-specific chitinase.
AU  - Vinetz, J. M.
AU  - Kaslow, D. C.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1998///
VL  - 90
IS  - 2
SP  - 199
EP  - 202
SN  - 0014-4894
AD  - Vinetz, J. M.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990802281.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 9001-06-3.  Subject Subsets: Protozoology
KW  - biochemistry
KW  - chitinase
KW  - enzymes
KW  - ookinetes
KW  - parasites
KW  - synthetic peptides
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - ookinete-specific chitinase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Diet during adolescence and risk of breast cancer among young women.
AU  - Potischman, N.
AU  - Weiss, H. A.
AU  - Swanson, C. A.
AU  - Coates, R. J.
AU  - Gammon, M. D.
AU  - Malone, K. E.
AU  - Brogan, D.
AU  - Stanford, J. L.
AU  - Hoover, R. N.
AU  - Brinton, L. A.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1998///
VL  - 90
IS  - 3
SP  - 226
EP  - 233
SN  - 0027-8874
AD  - Potischman, N.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981404146.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - Risk of early-onset breast cancer was examined in relation to diet during adolescence in a case-control study in the USA. Study participants were accrued from the following 3 geographical regions covered by cancer registries: Atlanta, GA; Seattle/Puget Sound, WA; and central New Jersey. Case patients (n=1647) were newly diagnosed with breast cancer in 1990-92, and control subjects (n=1501) were identified by random-digit-dialling techniques in the same period. In an interview, each subject was asked to recall the frequency of consumption and portion size of 29 key food items at ages 12-13 years. Mothers of a subset of respondents completed questionnaires and food groups were recalculated after removal of foods with poor agreement between mother and daughter. Logistic regression analyses were used to calculate odds ratios and 95% confidence intervals. When high vs. low quartiles of consumption were compared, there was a suggestion of a reduced risk associated with high consumption of fruits and vegetables, although this finding was not significant. Slight increases (of borderline significance) in risk of breast cancer were found for intake of chicken or high-fat meat. Intake of animal fat, high-fat foods, high-fat snacks and desserts, or milk products during adolescence had no apparent influence on breast cancer risk. Removal of foods suspected to be poorly recalled by the daughters did not change any of the risk estimates. It was concluded that these data do not provide evidence for a strong influence of dietary intakes during adolescence on risk of early-onset breast cancer.
KW  - adolescents
KW  - animal fat
KW  - breast
KW  - breast cancer
KW  - children
KW  - desserts
KW  - diet studies
KW  - fat
KW  - fruit
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - meat
KW  - milk products
KW  - neoplasms
KW  - risk
KW  - vegetables
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - breasts
KW  - cancers
KW  - dairy products
KW  - mammary tumour
KW  - teenagers
KW  - United States of America
KW  - vegetable crops
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a black population.
AU  - Manns, A.
AU  - Hanchard, B.
AU  - Morgan, O. St. C.
AU  - Wilks, R.
AU  - Cranston, B.
AU  - Nam JunMo
AU  - Blank, M.
AU  - Kuwayama, M.
AU  - Yashiki, S.
AU  - Fujiyoshi, T.
AU  - Blattner, W.
AU  - Sonoda, S.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1998///
VL  - 90
IS  - 8
SP  - 617
EP  - 622
SN  - 0027-8874
AD  - Manns, A.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19982007783.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - HLA class II alleles were studied among asymptomatic HTLV-I carriers (n = 45), patients with adult T-cell leukaemia/lymphoma (ATL; n = 49) or HTLV-I-associated myelopathy (HAM/TSP; n = 54), and HTLV-I-seronegative control subjects (n = 51) in Kingston, Jamaica. All participants were of African descent. Two antigens determined by serotyping, DR15 and DQ1, occurred at significantly increased frequency among HTLV-I carriers compared with seronegative control subjects (42% versus 22% for DR15 [odds ratio {OR} = 2.7; 95% confidence interval {CI} = 1.0-7.2] and 78% versus 53% for DQ1 [OR = 3.1; 95% CI = 1.2-8.5]). Asymptomatic carriers were shown to have an HLA class II allele distribution similar to that of patients with ATL, and the frequencies of the alleles DRB1*1501, DRB1*1101, and DQB1*0602 were significantly greater in patients with ATL and asymptomatic carriers than in patients with HAM/TSP. In addition, haplotypes DRB1*1101-DQB1*0301 and DRB1*1501-DQB1*0602 were significantly increased among patients with ATL compared with patients with HAM/TSP. These data suggest that host genetic background is an important factor in determining whether HTLV-I carriers develop either ATL or HAM/TSP.
KW  - adult T-cell leukaemia
KW  - alleles
KW  - antigens
KW  - asymptomatic infections
KW  - carriers
KW  - chronic course
KW  - classification
KW  - disease course
KW  - hosts
KW  - human diseases
KW  - identification
KW  - infection
KW  - major histocompatibility complex
KW  - myelopathy
KW  - serotypes
KW  - spastic paraparesis
KW  - T lymphocytes
KW  - tropical spastic paraparesis
KW  - Caribbean
KW  - Jamaica
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Deltaretrovirus
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - Threshold Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - adult T-cell leukemia
KW  - antigenicity
KW  - disease progression
KW  - histocompatibility complex
KW  - HTLV-BLV group
KW  - immunogens
KW  - T cells
KW  - West Indies
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica.
AU  - Manns, A.
AU  - Strickler, H. D.
AU  - Hanchard, B.
AU  - Manassaram, D. M.
AU  - Waters, D.
AU  - Ablashi, D. V.
T2  - Journal of the National Cancer Institute
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1998///
VL  - 90
IS  - 14
SP  - 1102
EP  - 1104
SN  - 0027-8874
AD  - Manns, A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19982011326.  Publication Type: Correspondence.  Language: English.  Number of References: 6 ref. Subject Subsets: Tropical Diseases
N2  - The seroprevalence of human herpesvirus 8 (HHV-8) was analysed by ELISA and immunofluorescence assay among 2 Jamaican populations: 250 normal blood donors (median age 41 years, range 18-64 years; 50% female) in Kingston and 146 women (median age 33 years, range 19-78 years) attending gynaecology clinics in Kingston. The overall seroprevalence among the blood donors tested was 3.6% (9/250), with 5.0% (6/119) of the men and 2.4% (3/122) of the women having detectable levels of HHV-8 antibodies. Men were 2 times more likely to be seropositive than women (odds ratio=2.1; 95% confidence interval [CI]=0.43-12.9). Blood donors aged &gt;40 years had a 2.9-fold greater likelihood of HHV-8 seropositivity (odds ratio=2.89; 95% CI=0.53-29), and the highest number of seropositives (6.9%) among both sexes was detected in individuals over the age of 50 years. Among the women attending the gynaecology clinics, only one patient (aged 44 years) of 146 (0.68%) was seropositive. These results indicate that the seroprevalence of HHV-8 among the Jamaican population varies predominantly by age and sex.
KW  - adults
KW  - age
KW  - blood donors
KW  - epidemiology
KW  - human diseases
KW  - seroprevalence
KW  - sex
KW  - viral diseases
KW  - Jamaica
KW  - Herpesviridae
KW  - Human herpesvirus 4
KW  - human herpesvirus 8
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - Rhadinovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - Epstein-Barr virus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011326&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews.
AU  - Silverman, D. T.
AU  - Swanson, C. A.
AU  - Gridley, G.
AU  - Wacholder, S.
AU  - Greenberg, R. S.
AU  - Brown, L. M.
AU  - Hayes, R. B.
AU  - Swanson, G. M.
AU  - Schoenberg, J. B.
AU  - Pottern, L. M.
AU  - Schwartz, A. G.
AU  - Fraumeni, J. F., Jr.
AU  - Hoover, R. N.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1998///
VL  - 90
IS  - 22
SP  - 1710
EP  - 1719
SN  - 0027-8874
AD  - Silverman, D. T.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19981418723.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Subject Subsets: Human Nutrition
N2  - Dietary factors were evaluated to determine whether the higher incidence of pancreatic cancer experienced by black Americans compared with white Americans could be explained. A population-based case-control study of pancreatic cancer diagnosed in Atlanta, Detroit and 10 New Jersey counties, USA, from August 1986 to April 1989 was carried out. Reliable dietary histories were obtained for 436 subjects and 2003 general-population control subjects aged 30-79 years. Obesity was associated with a significant 50%-60% increased risk of pancreatic cancer that was consistent by sex and race. Although the magnitude of risk associated with obesity was identical in blacks and whites, a higher percentage of blacks were obese than were whites (women 38 vs. 16%; men 27 vs. 22%). A significant positive trend in risk was observed with increasing energy intake, with subjects in the highest quartile of energy intake experiencing a 70% higher risk than those in the lowest quartile. A significant interaction between body mass index (weight in kg/height in m² for men and weight in kg/height in m1.5 for women) and total energy intake was observed that was consistent by sex and race. Subjects in the highest quartile of body mass index and energy intake had a significant 180% higher risk than those in the lowest quartile. It is concluded that obesity is a risk factor for pancreatic cancer and appears to contribute to the higher risk of pancreatic cancer among blacks than among whites in the USA, particularly among women. The interaction between body mass index and energy intake suggests the importance of energy balance in pancreatic carcinogenesis.
KW  - anthropometric dimensions
KW  - blacks
KW  - carcinogenesis
KW  - diet
KW  - dietary history
KW  - energy balance
KW  - energy intake
KW  - ethnic groups
KW  - ethnicity
KW  - neoplasms
KW  - nutrition
KW  - obesity
KW  - pancreas
KW  - risk factors
KW  - Georgia
KW  - Michigan
KW  - New Jersey
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southeastern States of USA
KW  - East North Central States of USA
KW  - North Central States of USA
KW  - Lake States of USA
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - anthropometric measurements
KW  - cancers
KW  - ethnic differences
KW  - fatness
KW  - food history
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418723&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcγ receptors and expression of monokines.
AU  - Swapan, K. De
AU  - Venkateshan, C. N. S.
AU  - Seth, P.
AU  - Gajdusek, D. C.
AU  - Gibbs, C. J. Jr.
JO  - Blood
JF  - Blood
Y1  - 1998///
VL  - 91
IS  - 6
SP  - 2108
EP  - 2117
SN  - 0006-4971
AD  - Swapan, K. De: Oral Infection and Immunity Branch, National Institute of Dental Research, the Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982005288.  Publication Type: Journal Article.  Language: English.  Number of References: 105 ref. Registry Number: 308079-78-9. 
N2  - To characterize the effect of HIV-1 nef expression in human monocytes/macrophage (HMØ) and U937 on the levels of FcγRs, HLA antigens, and monokines, elutriated HMØs and U937 cells were transfected with an adenovirus-mediated Nef expression system. Nef-expressing cells downmodulated FcγRI, FcγRII, and upregulated HLA class I molecules. Nef-expressing HMØs, treated with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA), overexpressed tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-10. However, IL-6 was induced by LPS and inhibited by PMA. Additionally, a subpopulation of Nef-expressing HMØs underwent apoptosis. These data suggest that HIV-1 nef downmodulated FcγRs in myeloid cells in a manner similar to that previously reported for its effect on CD4 in T cells.
KW  - antigens
KW  - apoptosis
KW  - macrophages
KW  - monocytes
KW  - Nef protein
KW  - pathogenesis
KW  - receptors
KW  - tumour necrosis factor
KW  - Adenoviridae
KW  - Human immunodeficiency virus 1
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - antigenicity
KW  - cachectin
KW  - cachexin
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005288&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Episomal and integrated maintenance of foreign DNA in Giardia lamblia.
AU  - Singer, S. M.
AU  - Yee, J.
AU  - Nash, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1998///
VL  - 92
IS  - 1
SP  - 59
EP  - 69
SN  - 0166-6851
AD  - Singer, S. M.: Laboratory of Parasitic Disease, Building 4/Room B1-06, 9000 Rockville Pike, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980806279.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 9007-49-2, 53-79-2.  Subject Subsets: Protozoology; Agricultural Biotechnology
N2  - A method was developed for stably introducing DNA into the nuclei of Giardia lamblia [G. duodenalis] using puromycin acetyltransferase (pac) as a dominant selectable marker. Transfected circular DNAs were maintained as episomes in the isolate WB, a representative of one Giardia subgroup. When input DNAs were linearized, integration occurred by homologous recombination, producing gene replacements in this isolate. In isolate GS, which represents a different subgroup, both linear and circular transfected DNAs were integrated into the genome by homologous recombination. In GS, linear DNA again produced gene replacements, whereas circular DNA produced duplicative integration events. The failure of GS to replicate episomes may reflect differences in the structure or recognition of DNA replication origins between these subgroups. A plasmid shuttle vector was also developed for expression of other genes in G. lamblia. Utilizing the green fluorescent protein as a reporter gene in the WB isolate, it was shown that gene expression from this vector correlated with plasmid copy number over a range of 2 orders of magnitude.
KW  - biotechnology
KW  - DNA
KW  - molecular genetics
KW  - parasites
KW  - plasmids
KW  - puromycin
KW  - recombination
KW  - reporter genes
KW  - transfection
KW  - Giardia duodenalis
KW  - protozoa
KW  - Giardia
KW  - Hexamitidae
KW  - Diplomonadida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - deoxyribonucleic acid
KW  - gene replacements
KW  - genetic recombination
KW  - puromycin acetyltransferase
KW  - reporter gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806279&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected.
AU  - Tisdale, J. F.
AU  - Stewart, A. K.
AU  - Dickstein, B.
AU  - Little, R. F.
AU  - Dubé, I.
AU  - Cappe, D.
AU  - Dunbar, C. E.
AU  - Brown, K. E.
JO  - Blood
JF  - Blood
Y1  - 1998///
VL  - 92
IS  - 8
SP  - 2681
EP  - 2687
SN  - 0006-4971
AD  - Tisdale, J. F.: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA.
N1  - Accession Number: 19992001524.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 308067-58-5.  Subject Subsets: Public Health
N2  - Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig (et al.) Science (1997) 276, 1851-1854). In this study, the authors sought to confirm these observations in their own group of MM patients (n=30). DNA was extracted from adherent stromal cells grown under varying conditions and assayed for HHV-8 sequence using PCR to amplify the orf 26 (KS330) sequence (Chang et al.Science (1994) 266, 1865-1869), as initially reported. Samples from human control subjects (n=25) were concurrently extracted and analysed. After 30 cycles of amplification, no positive samples were detected. In a more sensitive nested PCR, samples from 18 of 30 (60%) MM patients were positive, at about the limit of detection, but orf 26 sequence was also amplified from 11 of 25 (44%) human control samples. However, PCR amplification from other regions of the viral genome (orf 72 and orf 75) was uniformly negative for all MM and control samples, despite equivalent sensitivity. Additionally, all sera from MM patients were negative for HHV-8 IgG by immunofluorescence. It is concluded that the data do not support a role of HHV-8 in the aetiology of MM but may suggest the presence of a related (KS330-containing) virus in MM patients and in some control subjects.
KW  - aetiology
KW  - DNA amplification
KW  - human diseases
KW  - IgG
KW  - myeloma
KW  - neoplasms
KW  - plasma cells
KW  - polymerase chain reaction
KW  - serology
KW  - seroprevalence
KW  - human herpesvirus 8
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001524&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.
AU  - Jin DongYan
AU  - Spencer, F.
AU  - Jeang KuanTeh
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1998///
VL  - 93
IS  - 1
SP  - 81
EP  - 91
SN  - 0092-8674
AD  - Jin DongYan: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19982006875.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
N2  - A search for cellular targets of the HTLV-I oncoprotein Tax identified TXBP181, which was characterized as the human homologue of yeast mitotic checkpoint MAD1 protein. Evidence supporting TXBP181 as HsMAD1 includes sequence conservation with yeast MAD1, hyperphosphorylation during S/G2/M phases and upon treatment of cells with nocodazole, and binding to HsMAD2. HsMAD1 functions as a homodimer. It localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telophase. Expression of either Tax or a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consistent with a loss of HsMAD1 function. A model of viral transformation is proposed in which Tax targets TXBP181, thereby abrogating a midpoint checkpoint.
KW  - human diseases
KW  - mitosis
KW  - pathogenesis
KW  - phenotypes
KW  - proteins
KW  - T lymphocytes
KW  - Tax protein
KW  - treatment
KW  - yeasts
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - fungi
KW  - eukaryotes
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - fungus
KW  - HTLV-BLV group
KW  - oncogenesis
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006875&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular epidemiology of human polyomavirus JC in the Biaka Pygmies and Bantu of Central Africa.
AU  - Chima, S. C.
AU  - Ryschkewitsch, C. F.
AU  - Stoner, G. L.
JO  - Memórias do Instituto Oswaldo Cruz
JF  - Memórias do Instituto Oswaldo Cruz
Y1  - 1998///
VL  - 93
IS  - 5
SP  - 615
EP  - 623
SN  - 0074-0276
AD  - Chima, S. C.: Neurotoxicology Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992004129.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Tropical Diseases
N2  - Based on sequence analysis of JCV complete genomes or fragments thereof, polyomavirus JC (JCV) can be classified into geographically derived genotypes. Types 1 and 2 are of European and Asian origin, respectively, whereas Types 3 and 6 are African in origin. Type 4, a possible recombinant of European and African genotypes (1 and 3) is common in the USA. To delineate the JCV genotypes in an aboriginal African population, random urine samples were collected from the Biaka Pygmies and Bantu from the Central African Republic. The study group consisted of 43 males and 25 females aged 4-55 years, with an average age of 26 years. After PCR amplification of JCV in urine, products were sequenced. Five of 23 Pygmy adults (22%) and 4 of 20 Bantu adults (20%) were positive for JC viruria. DNA sequence analysis revealed JCV Type 3, Type 6 and Type 1 variants in 2, 2 and 1 Biaka Pygmies, respectively. All the Bantu strains were Type 6. It is suggested that the presence of multiple subtypes of JCV in Biaka Pygmies may be a result of extensive interactions of Pygmies with their African tribal neighbours.
KW  - disease prevalence
KW  - genetic variation
KW  - genotypes
KW  - human diseases
KW  - molecular epidemiology
KW  - Central African Republic
KW  - JC polyomavirus
KW  - man
KW  - Polyomavirus
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - JC virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004129&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transmission of spongiform encephalopathy through biological products.
AU  - Brown, P.
JO  - Developments in Biological Standardization
JF  - Developments in Biological Standardization
Y1  - 1998///
VL  - 93
SP  - 73
EP  - 78
SN  - 0301-5149
AD  - Brown, P.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992202447.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Veterinary Science
KW  - blood
KW  - blood plasma
KW  - bovine spongiform encephalopathy
KW  - Creutzfeldt-Jakob disease
KW  - disease transmission
KW  - grafts
KW  - prion diseases
KW  - public health
KW  - spongiform encephalopathy
KW  - bovine encephalopathy
KW  - BSE
KW  - mad cow disease
KW  - plasma (blood)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202447&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An amino terminal intron indicates that transcripts for the Plasmodium falciparum Golgi network marker Rab6 do not encode alternative amino termini.
AU  - Templeton, T. J.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1998///
VL  - 94
IS  - 1
SP  - 149
EP  - 153
SN  - 0166-6851
AD  - Templeton, T. J.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room B1-31, NIAID/NIH, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980808811.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Protozoology
N2  - The 5′ end of the pfrab6 gene of Plasmodium falciparum was analysed in detail for the presence of introns. From the results it is concluded that a single rab6 gene exists in the P. falciparum genome, and the identification of an amino terminal intron indicates that pfrab6 does not posess alternative amino termini. Nucleotide sequence data have been submitted to GenBank under accession number AF035011.
KW  - amino acid sequences
KW  - complementary DNA
KW  - endoplasmic reticulum
KW  - genes
KW  - Golgi apparatus
KW  - introns
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - pfrab6
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808811&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers.
AU  - Wellems, T. E.
AU  - Wootton, J. C.
AU  - Fujioka, H.
AU  - Su XinZhuan
AU  - Cooper, R.
AU  - Baruch, D.
AU  - Fidock, D. A.
JO  - Cell (Cambridge)
JF  - Cell (Cambridge)
Y1  - 1998///
VL  - 94
IS  - 3
SP  - 285
EP  - 286
SN  - 0092-8674
AD  - Wellems, T. E.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980808296.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 1333-74-0, 7440-23-5.  Subject Subsets: Protozoology
N2  - Evidence is presented to show that the CG2 protein gene (cg2) of Plasmodium falciparum, which has been linked to chloroquine resistance, does not encode a sodium/hydrogen exchanger (NHE) responsible for drug transport, as has been proposed. A detailed reanalysis of the CG2 sequence failed to support claims for significant similarity to functional features of well-characterized eukaryotic NHE transport domains. The possible role of CG2 in chloroquine resistance is discussed.
KW  - antimalarials
KW  - antiprotozoal agents
KW  - chloroquine
KW  - drug resistance
KW  - genes
KW  - human diseases
KW  - hydrogen
KW  - malaria
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - sodium
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - biochemical genetics
KW  - CG2 protein
KW  - DNA sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808296&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A previously unidentified host protein protects retroviral DNA from autointegration.
AU  - Lee, M. S.
AU  - Cragie, R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 4
SP  - 1528
EP  - 1533
SN  - 0027-8424
AD  - Lee, M. S.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982004440.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9007-49-2. 
KW  - chromosomes
KW  - DNA
KW  - fibroblasts
KW  - genomes
KW  - hosts
KW  - human immunodeficiency viruses
KW  - integration
KW  - peptides
KW  - proteins
KW  - Escherichia coli
KW  - Retroviridae
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - E. coli
KW  - human immunodeficiency virus
KW  - virions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004440&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge.
AU  - Belyakov, I. M.
AU  - Derby, M. A.
AU  - Ahlers, J. D.
AU  - Kelsall, B. L.
AU  - Earl, P.
AU  - Moss, B.
AU  - Strober, W.
AU  - Berzofsky, J. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 4
SP  - 1709
EP  - 1714
SN  - 0027-8424
AD  - Belyakov, I. M.: Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982004442.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9008-11-1. 
N2  - Intrarectal immunization with a synthetic, multideterminant HIV peptide plus cholera toxin adjuvant induced long-lasting, antigen specific cytotoxic T-lymphocyte (CTL) memory in both the inductive (Peyer's patch) and effector (lamina propria) mucosal sites, as well as in systemic sites (spleen), whereas systemic immunization induced specific CTLs only in the spleen. Cholera toxin adjuvant, while enhancing the response, was not essential. The CTLs recognized target cells either pulsed with HIV peptide or expressing endogenous whole envelope glycoprotein of Mr 160 000 (gp160). It is shown that mucosal CTL responses are both interleukin 12 and interferon-γ dependent by using antibody-treated and knock-out mice. Finally, it is shown that intrarectal immunization with the synthetic HIV peptide vaccine protected mice against infection via mucosal challenge with a recombinant vaccinia virus expressing HIV-1IIIB gp160. These studies provide an approach to development of an HIV vaccine that induces CTL immunity in the mucosal and systemic immune systems and protects against mucosal infection with a virus expressing HIV-1 gp160.
KW  - adjuvants
KW  - antigens
KW  - bacterial toxins
KW  - cholera
KW  - cytotoxic T lymphocytes
KW  - cytotoxicity
KW  - envelope glycoproteins
KW  - envelope protein gp160
KW  - glycoproteins
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunity
KW  - immunization
KW  - infection
KW  - interferon
KW  - interleukins
KW  - lymphocytes
KW  - mucosa
KW  - peptides
KW  - spleen
KW  - T lymphocytes
KW  - toxins
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - mice
KW  - vaccinia virus
KW  - Vibrio cholerae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - gp160
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - mucous membrane
KW  - recombinant viruses
KW  - T cells
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004442&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.
AU  - Mahana, W.
AU  - Zhao, T. M.
AU  - Teller, R.
AU  - Robinson, M. A.
AU  - Kindt, T. J.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 4
SP  - 1782
EP  - 1787
SN  - 0027-8424
AD  - Mahana, W.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Facility, NIH, 12441 Parklawn Drive, Rockville, MD 20892, USA.
N1  - Accession Number: 19982004445.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - HTLV-I causes acute leukaemic disease in a low percentage of infected individuals through obscure mechanisms. These studies compare 2 rabbit HTLV-I-infected T-cell lines: one, RH/K34, causes lethal experimental leukaemia and the other, RN/K30, mediates asymptomatic infection. It is shown that the product of the protooncogene vav is constitutively Tyr-phosphorylated in RH/K34 but not in RH/K30. A role for the retrovirus in phosphorylation of Vav was assigned by transfection experiments with molecular clones of HTLV-I derived from the 2 lines. The HTLV-I molecular clone from RN/K30, but not that from RN/K34, down-regulates Vav phosphorylation in a Herpesvirus ateles-transformed T-cell line. Use of recombinant virus clones revealed that pX region sequence differing by 2 nucleotides between the 2 clones mediates this down-regulation. Because Vav is involved in T-cell signalling and Vav phosphorylation occurs upon activation of T cells, control of the activation state of Vav by viral proteins may relate to the leukaemogenic potential of certain HTLV-I-infected cells.
KW  - asymptomatic infections
KW  - cell lines
KW  - clones
KW  - genes
KW  - HTLV infections
KW  - human diseases
KW  - leukaemia
KW  - oncogenes
KW  - pathogenesis
KW  - proteins
KW  - T lymphocytes
KW  - viral proteins
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - rabbits
KW  - viruses
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - blood cancer
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - leucaemia
KW  - leukemia
KW  - T cells
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004445&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T cell lymphotropic virus type I Tax protein trans-activated interleukin 15 gene transcription through an NF-κB site.
AU  - Azimi, N.
AU  - Brown, K.
AU  - Bamford, R. N.
AU  - Tagaya, Y.
AU  - Siebenlist, U.
AU  - Waldmann, T. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 5
SP  - 2452
EP  - 2457
SN  - 0027-8424
AD  - Azimi, N.: Bldg 10, Rm 4N-102, National Cancer Institute, NIH 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005322.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - This study demonstrates that IL-15 mRNA can be detected in freshly isolated normal T cells and T cell lines. Furthermore, its expression is 3- to 4-fold higher in HTLV-I-infected T cells. By the use of reporter constructs bearing the 5′ regulatory region of the IL-15 gene, a positive correlation was observed between HTLV-I Tax protein expression and IL-15 promoter activity in HTLV-I-infected T cells. By using a Jurkat T cell transfectant that expresses Tax under an inducible promoter, it was also demonstrated that the expression of IL-15 mRNA increased 3-fold as Tax was expressed, suggesting that the Tax protein activates IL-15 transcription. An NF-κB consensus sequence is located at the -75 and -65 region of the IL-15 5′ regulatory region. Mutations in the NF-κB motif or deletion of this sequence abrogated the promoter activity in both HTLV-I-positive and Jurkat Tax-transfectant cells.
KW  - human diseases
KW  - interleukins
KW  - messenger RNA
KW  - mutations
KW  - pathogenesis
KW  - promoters
KW  - T lymphocytes
KW  - Tax protein
KW  - transactivation
KW  - transcription
KW  - transcription factors
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - DNA transcription
KW  - HTLV-BLV group
KW  - mRNA
KW  - nuclear factor kappaB
KW  - nuclear factors
KW  - promoter region
KW  - promoter sequences
KW  - T cells
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005322&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.
AU  - Conant, K.
AU  - Garzini-Demo, A.
AU  - Nath, A.
AU  - McArthur, J. C.
AU  - Halliday, W.
AU  - Power, C.
AU  - Gallo, R. C.
AU  - Major, E. O.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 6
SP  - 3117
EP  - 3121
SN  - 0027-8424
AD  - Conant, K.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bldg 36, Rm 5W21, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005325.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. This study shows that the HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte chemoattractant protein-1 (MCP-1). Astrocytic release of β-chemokines, which are relatively less selective for monocytes, including RANTES, macrophage inflammatory protein-1α, and macrophage inflammatory protein-1β, was not observed. It is also shown that MCP-1 is expressed in the brains of patients with HIV-1-associated dementia and that, of the β-chemokines tested, only MCP-1 could be detected in the cerebrospinal fluid of patients with this condition. Together, these data provide a potential link between the presence of HIV-1 in the brain and the monocytic infiltration that may substantially contribute to dementia.
KW  - acquired immune deficiency syndrome
KW  - central nervous system
KW  - cerebrospinal fluid
KW  - chemokines
KW  - cytokines
KW  - dementia
KW  - eicosanoids
KW  - human diseases
KW  - macrophages
KW  - monocytes
KW  - nervous system diseases
KW  - pathogenesis
KW  - Tat protein
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CNS
KW  - human immunodeficiency virus type 1
KW  - neuropathy
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005325&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum preferentially invades vesicular ATPase-expressing cells in Aedes aegypti midgut.
AU  - Mohammed Shahabuddin
AU  - Pimenta, P. F. P.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 7
SP  - 3385
EP  - 3389
SN  - 0027-8424
AD  - Mohammed Shahabuddin: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980807522.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9000-83-3.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - It was shown that the ookinetes of P. gallinaceum selectively invade a cell type in the A. aegypti midgut. These cells, unlike the majority of the cells in the midgut, do not stain with a basophilic dye (toluidine blue) and are less osmiophilic. In addition, they contain minimal endoplasmic reticulum, lack secretory granules, and have few microvilli. They are highly vacuolated and express large amounts of vesicular ATPase which is associated with the apical plasma membrane, cytoplasmic vesicles, and tubular extensions of the basal membrane of the invaded cells.
KW  - adenosinetriphosphatase
KW  - cell invasion
KW  - disease transmission
KW  - disease vectors
KW  - host parasite relationships
KW  - midgut
KW  - ookinetes
KW  - parasites
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - ATPase
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807522&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase.
AU  - Szczepanowska, J.
AU  - Ramachandran, U.
AU  - Herring, C. J.
AU  - Gruschus, J. M.
AU  - Jun Qin
AU  - Korn, E. D.
AU  - Brzeska, H.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 8
SP  - 4146
EP  - 4151
SN  - 0027-8424
AD  - Szczepanowska, J.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980807404.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 72-19-5.  Subject Subsets: Protozoology
N2  - Phosphorylation of Ser-627 is both necessary and sufficient for full activity of the expressed 35-kDa catalytic domain of myosin I heavy chain kinase (MIHCK). The effects of individually substituting Ala, Asp and Glu for each of the 3 hydroxyamino acids (Ser-627, Thr-631 and Thr-632) in the variable loop of Acanthamoeba MIHCK was investigated. The S627A mutant was substantially less active than wild type (wt), with a lower kcat and higher Km for both peptide substrate and ATP, but was more active than unphosphorylated wt. The S627D and S627E mutants were also less active than phosphorylated wt, indicating that acidic amino acids could not substitute for phospho-Ser-627. The activity of the T631A mutant was as low as that of the S627A mutant, whereas the T632A mutant was as active as phosphorylated wt, indicating that highly conserved Thr-631, although not phosphorylated, was essential for catalytic activity. Asp and Glu substitutions for Thr-631 and Thr-632 were inhibitory to various extents. Molecular modelling indicated that Thr-631 could hydrogen bond with conserved residue Asp-591 in the catalytic loop and that similar interactions were possible for other kinases whose activities were also regulated by phosphorylation in the variable loop. It is therefore suggested that this conserved Thr residue may be essential for the activities of other Ser/Thr protein kinases as well as for the activity of MIHCK.
KW  - activity
KW  - amino acids
KW  - biochemistry
KW  - kinases
KW  - myosins
KW  - parasites
KW  - phosphorylation
KW  - threonine
KW  - Acanthamoeba
KW  - protozoa
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - myosin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807404&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
AU  - Lubkowski, J.
AU  - Yang, F.
AU  - Alexandratos, J.
AU  - Wlodawer, A.
AU  - Zhao He
AU  - Burke, T. R. Jr.
AU  - Neamati, N.
AU  - Pommier, Y.
AU  - Merkel, G.
AU  - Skalka, A. M.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 9
SP  - 4831
EP  - 4836
SN  - 0027-8424
AD  - Lubkowski, J.: Macromolecular Structure Laboratory, Advanced BioScience Laboratories-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19982007306.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - The X-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-Å at two pH values, with and without Mn2+ cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activity of HIV type 1 integrase (HIV-1 IN), was found in this study to be active against ASV IN as well as HIV-1 IN. The Y-3 molecule is located in close proximity to the enzyme active site, interacts with the flexible loop, alters loop conformation, and affects the conformations of active site residues. As crystallized, a Y-3 molecule stacks against its symmetry-related mate. Preincubation of IN with metal cations does not prevent inhibition, and Y-3 binding does not prevent binding of divalent cations to IN. Three compounds chemically related to Y-3 also were investigated, but no binding was observed in the crystals. These results identify the structural elements of the inhibitor that likely determine its binding properties.
KW  - animal models
KW  - catalytic activity
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - inhibition
KW  - inhibitors
KW  - integration
KW  - structure
KW  - birds
KW  - Human immunodeficiency virus 1
KW  - Retroviridae
KW  - Rous sarcoma virus
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Alpharetrovirus
KW  - avian sarcoma virus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007306&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication.
AU  - Grossman, Z.
AU  - Feinberg, M. B.
AU  - Paul, W. E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 11
SP  - 6314
EP  - 6319
SN  - 0027-8424
AD  - Grossman, Z.: The Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982008515.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
N2  - CD4+ T cell activation, required for virus replication in these cells, occurs in local microenvironmental domains in transient bursts. Thus, although most HIV originates from short-lived virus-producing cells, it is unlikely that chronic infection is generally sustained in rapid continuous cycles of productive infection as has been proposed. Such continuity of productive infection cycles would depend on efficient long-range transmission of HIV from one set of domains to another, in turn requiring the maintenance of sufficiently high concentrations of cell-free virus across lymphoid tissues at all times. By contrast, long-lived cellular sources of HIV maintain the capacity to infect newly activated cells at close range despite the temporal and spatial discontinuities of activation events. Such proximal activation and transmission (PAT) involving chronically and latently infected cells may be responsible for sustained infection, particularly when viral loads are low. Once CD4+ cells are productively infected through PAT, they can infect other activated cells in their immediate vicinity. Such events propagate locally but generally do not spread systemically, unlike in the acute phase of the infection, because of the early establishment of protective anergy. Importantly, antiretroviral drug treatment is likely to differentially impact long-range transmission and PAT.
KW  - antiviral agents
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - chronic course
KW  - concentration
KW  - culture media
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - infection
KW  - latent infections
KW  - lymphocyte transformation
KW  - pathogenesis
KW  - replication
KW  - T lymphocytes
KW  - transmission
KW  - treatment
KW  - viral replication
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - CD4+ cells
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - T4 lymphocytes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels.
AU  - Li-Smerin YingYing
AU  - Swartz, K. J.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 15
SP  - 8585
EP  - 8589
SN  - 0027-8424
AD  - Li-Smerin YingYing: Molecular Physiology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980506043.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 14127-61-8.  Subject Subsets: Medical & Veterinary Entomology
N2  - Hanatoxin and grammotoxin are related protein toxins found in the venom of the Chilean rose tarantula, Phrixotrichus spatulata. Hanatoxin inhibits voltage-gated K+ channels and grammotoxin inhibits voltage-gated Ca2+ channels. Both toxins inhibit their respective channels by interfering with normal operation of the voltage-dependent gating mechanism. The sequence homology of hanatoxin and grammotoxin, as well as their similar mechanism of action, raises the possibility that they interact with the same region of voltage-gated Ca2+ and K+ channels. It was shown that each toxin can interact with both voltage-gated Ca2+ and K+ channels and modify channel gating. Moreover, mutagenesis of voltage-gated K+ channels suggests that hanatoxin and grammotoxin recognize the same structural motif. It is proposed that these toxins recognize a voltage-sensing domain or module present in voltage-gated ion channels and that this domain has a highly conserved 3-d structure.
KW  - biochemistry
KW  - calcium ions
KW  - ion transport
KW  - molecular conformation
KW  - neurotoxicity
KW  - proteins
KW  - structure activity relationships
KW  - toxins
KW  - venoms
KW  - Arachnida
KW  - Theraphosidae
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Araneae
KW  - Arachnida
KW  - grammotoxin
KW  - hanatoxin
KW  - Phrixotrichus
KW  - Phrixotrichus spatulata
KW  - toxinology
KW  - venom
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506043&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection.
AU  - Chun TaeWook
AU  - Engel, D.
AU  - Berrey, M. M.
AU  - Shea, T.
AU  - Corey, L.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 15
SP  - 8869
EP  - 8873
SN  - 0027-8424
AD  - Chun TaeWook: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, Rm 6A32, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982011099.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9007-49-2. 
N2  - The presence of latently infected, resting CD4+ T cells carrying replication-competent HIV-1 has been demonstrated in chronically infected individuals who are antiretroviral therapy naive as well as in those who are receiving highly active antiretroviral therapy (HAART). It is not clear, however, whether the establishment of a pool of latently infected CD4+ T cells can be blocked by early initiation of HAART after primary infection. This study demonstrates that initiation of HAART in infected individuals as early as 10 days after the onset of symptoms of primary HIV-1 infection did not prevent generation of latently infected, resting CD4+ T cells carrying integrated HIV-1 DNA as well as infectious HIV-1, despite the successful control of plasma viraemia shortly after institution of HAART. Furthermore, there was no correlation between either the duration of HAART at the time of study (range: 0.2-17 months) or the time of initiation of HAART after the onset of symptoms of primary HIV-1 infection (range: 0.3-4 months) and the frequencies of resting CD4+ T cells carrying either integrated HIV-1 DNA or infectious virus. These results underscore the rapidity with which latent reservoirs are established in primary HIV-1 infection and indicate that it is unlikely that early treatment during primary infection can prevent establishment of a pool of latently infected, resting CD4+ T cells as long as treatment is initiated after plasma viraemia becomes evident.
KW  - antiviral agents
KW  - blood plasma
KW  - CD4+ lymphocytes
KW  - DNA
KW  - drug therapy
KW  - human diseases
KW  - immunopathology
KW  - latent infections
KW  - pathogenesis
KW  - symptoms
KW  - treatment
KW  - viraemia
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4+ cells
KW  - chemotherapy
KW  - deoxyribonucleic acid
KW  - human immunodeficiency virus type 1
KW  - immunopathogenesis
KW  - plasma (blood)
KW  - T4 lymphocytes
KW  - viremia
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011099&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.
AU  - Valentin, A.
AU  - Lu WenHong
AU  - Rosati, M.
AU  - Schneider, R.
AU  - Albert, J.
AU  - Karlsson, A.
AU  - Pavlakis, G. N.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 15
SP  - 8886
EP  - 8891
SN  - 0027-8424
AD  - Valentin, A.: Advanced BioScience Laboratories-Basic Research Program, Bldg 535, Rm 212, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982011100.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 207137-56-2. 
N2  - This study shows that interleukin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms. It differentially regulates the two major HIV-1 coreceptors, CCR5 and CXCR4, in human peripheral blood mononuclear cells, increasing CXCR4 and decreasing CCR5 expression in primary CD4+ T-lymphocytes. In addition, IL-4 stimulates the expression of all HIV-1 isolates via a transcriptional activation mechanism. The combination of these effects results in increased propagation of CXCR4-using and inhibition of CCR5-using HIV-1 strains. IL-4 also activates HIV-1 expression in primary monocytes/macrophages but does not affect CCR5 expression. These results identify IL-4 as an important regulator of HIV-1 and suggest a critical role for this cytokine in the control of viral evolution and in the phenotypic switch from non-syncytia-inducing to syncytia-inducing, which leads to accelerated disease progression.
KW  - chemokines
KW  - cytokines
KW  - disease course
KW  - effects
KW  - human diseases
KW  - interleukin 4
KW  - interleukins
KW  - pathogenesis
KW  - phenotypes
KW  - receptors
KW  - syncytia
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - disease progression
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011100&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.
AU  - Goldgur, Y.
AU  - Dyda, F.
AU  - Hickman, A. B.
AU  - Jenkins, T. M.
AU  - Craigie, R.
AU  - Davies, D. R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 16
SP  - 9150
EP  - 9154
SN  - 0027-8424
AD  - Goldgur, Y.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982011102.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 7439-95-4. 
N2  - Three additional crystal structures of the core domain of HIV-1 integrase mutants, crystallized in the presence and absence of cacodylate, as well as complexed with Mg2+, are reported. These 3 crystal forms, containing between them 7 independent core domain structures, demonstrate the unambigouous extension of the previously disordered helix α4 toward the amino terminus from residue M154 and show that the catalytic E152 points in the general direction of the two catalytic aspartates, D64 and D116. In the vicinity of the active site, the structure of the protein in the absence of cacodylate exhibits significant deviations from the previously reported structures. These differences can be attributed to the modification of C65 and C130 by cacodylate, which was an essential component of the original crystallization mixture. It was also demonstrated that, in the absence of cacodylate, this protein will bind to Mg2+, and could provide a satisfactory platform for binding of inhibitors.
KW  - binding
KW  - enzymes
KW  - human diseases
KW  - integration
KW  - magnesium
KW  - structure
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - active site
KW  - human immunodeficiency virus type 1
KW  - integrase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011102&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Footprints on the viral DNA ends in Moloney murine leukemia virus preintegration complexes reflect a specific association with integrase.
AU  - Wei ShuiQing
AU  - Mizuuchi, K.
AU  - Craigie, R.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 18
SP  - 10535
EP  - 10540
SN  - 0027-8424
AD  - Wei ShuiQing: Bldg 5, Rm 301, National Institute of Diabetes and Digestive and Kidney diseases, NIH, 5 Center Drive, MSC 0560, Bethesda, MD 20892-0560, USA.
N1  - Accession Number: 19982013704.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 9007-49-2. 
N2  - Retroviral DNA integration is mediated by the preintegration complex, a large nucleoprotein complex derived from the core of the infecting virion. Mu-mediated PCR was previously used to probe the nucleoprotein organization of Moloney murine leukaemia virus preintegration complexes. A region of protection spans several hundred base pairs at each end of the viral DNA, and strong enhancements are present near the termini. The current study shows that these footprints reflect a specific association between integrase and the viral DNA ends in functional preintegration complexes. Barrier-to-autointegration factor, a cellular protein that blocks autointegration of Moloney murine leukaemia virus DNA, also plays an indirect role in generating the footprints at the ends of the viral DNA. Mu-mediated PCR was used to examine the effect of mutations at the viral DNA termini on complex formation. It was found that a replication competent mutant with a deletion at one end of the viral DNA still exhibits a strong enhancement about 20 bp from the terminus of the mutant DNA end. The site of the enhancement therefore appears to be at a fixed distance from the ends of the viral DNA. It was also found that a mutation at one end of the viral DNA, which renders the virus incompetent for replication, abolishes the enhancements and protection at both the U3 and U5 ends. A pair of functional viral DNA ends therefore is required to interact before the chemical step of 3′ end processing.
KW  - animal models
KW  - DNA
KW  - human diseases
KW  - integration
KW  - mutations
KW  - nucleoproteins
KW  - polymerase chain reaction
KW  - replication
KW  - mice
KW  - Murine leukemia virus
KW  - Retroviridae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - deoxyribonucleic acid
KW  - integrase
KW  - murine leukaemia virus
KW  - PCR
KW  - virions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013704&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reconstitution of HIV-1 Rev nuclear export: independent requirements for nuclear import and export.
AU  - Love, D. C.
AU  - Sweitzer, T. D.
AU  - Hanover, J. A.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 18
SP  - 10608
EP  - 10613
SN  - 0027-8424
AD  - Love, D. C.: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bldg 8, Rm 402, 8 Center Drive, Bethesda, MD 20892-0851, USA.
N1  - Accession Number: 19982013705.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 56-65-5, 63231-63-0. 
N2  - Cell lines expressing a green fluorescent protein-labelled chimeric protein consisting of HIV-1 Rev and a hormone-inducible nuclear localization sequence were generated. Steroid removal switches off import thus allowing direct visualization of the Rev export pathway in living cells. After digitonin permeabilization of these cells, a functional nuclear export sequence (NES), ATP, and fractionated cytosol were sufficient for nuclear export in vitro. Nuclear pore-specific lectins and leptomycin B were potent export inhibitors. Nuclear export was not inhibited by antagonists of calcium metabolism that block nuclear import. These data further suggest that nuclear pores do not functionally close when luminal calcium stores are depleted. The distinct requirements for nuclear import and export argue that these competing processes may be regulated independently. This system should have wide applicability for the analysis of nuclear import and export.
KW  - ATP
KW  - cell lines
KW  - human diseases
KW  - in vitro
KW  - localization
KW  - proteins
KW  - Rev protein
KW  - RNA
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - adenosine triphosphate
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013705&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART.
AU  - Berger, E. A.
AU  - Moss, B.
AU  - Pastan, I.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 20
SP  - 11511
EP  - 11513
SN  - 0027-8424
AD  - Berger, E. A.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Rm 236, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014288.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
N2  - The success of highly active anti-retroviral therapy (HAART) has inspired new concepts for eliminating HIV from infected individuals. A major obstacle is the persistence of long-lived reservoirs of latently infected cells that might become activated at some time after cessation of therapy. It is proposed that, in the context of treatment strategies to deliberately activate and eliminate these reservoirs, hybrid toxins targeted to kill HIV-infected cells be reconsidered in combination with HAART. Such combinations might also prove valuable in protocols aimed at preventing mother-to-child transmission and establishment of infection immediately after exposure to HIV. Experimental approaches in vitro and in animal models are suggested to test various issues related to safety and efficacy of this concept.
KW  - antiviral agents
KW  - combination therapy
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - toxins
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - combined modality therapy
KW  - human immunodeficiency virus
KW  - multimodal treatment
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014288&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reactivity of the HIV-1 nucleocapsid protein p7 zinc finger domains from the perspective of density-functional theory.
AU  - Maynard, A. T.
AU  - Huang, M.
AU  - Rice, W. G.
AU  - Covell, D. G.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 20
SP  - 11578
EP  - 11583
SN  - 0027-8424
AD  - Maynard, A. T.: Frederick Cancer Research and Development Center, National Cancer Institute, Science Applications International Corporation, Frederick, MD 21702, USA.
N1  - Accession Number: 19982014289.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 7440-66-6. 
KW  - human diseases
KW  - nucleocapsid proteins
KW  - structure
KW  - zinc
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014289&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 Tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.
AU  - Weissman, J. D.
AU  - Brown, J. A.
AU  - Howcroft, T. K.
AU  - Hwang Jae
AU  - Chawla, A.
AU  - Roche, P. A.
AU  - Schiltz, L.
AU  - Nakatani, Y.
AU  - Singer, D. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 20
SP  - 11601
EP  - 11606
SN  - 0027-8424
AD  - Weissman, J. D.: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014290.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref.
N2  - These studies were designed to elucidate the mechanism of Tat repression and to identify any cellular factors with which Tat may interact in repressing MHC class I transcription. It is reported that Tat interacts with TAFII250, a component of the general transcription factor, TFIID, resulting in repression of MHC class I transcription in vitro. Tat binds to the histone acetyl transferase (HAT) domain of TafII250, inhibiting its activity. There was a correlation between promoter dependence on TAFII250 and susceptibility to Tat-mediated repression. These observations provide a possible mechanism for Tat repression through its binding to TAFII250.
KW  - gene expression
KW  - human diseases
KW  - major histocompatibility complex
KW  - pathogenesis
KW  - Tat protein
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - histocompatibility complex
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014290&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+ T cells: Role of signal transduction.
AU  - Kinter, A.
AU  - Catanzaro, A.
AU  - Monaco, J.
AU  - Ruiz, M.
AU  - Justement, J.
AU  - Moir, S.
AU  - Arthos, J.
AU  - Oliva, A.
AU  - Ehler, L.
AU  - Mizell, S.
AU  - Jackson, R.
AU  - Ostrowski, M.
AU  - Hoxie, J.
AU  - Offord, R.
AU  - Fauci, A. S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 20
SP  - 11880
EP  - 11885
SN  - 0027-8424
AD  - Kinter, A.: Bldg 10, Rm. 6A33, 10 Centre Dr., MSC-1576, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-1576, USA.
N1  - Accession Number: 19982014291.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
N2  - This study demonstrates that several CC-chemokines, including those that inhibit entry and replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic strains in CD4+ T cells. Enhancement of T-tropic HIV replication is observed at early stages of replication, requires signalling through inhibitory guanine nucleotide-binding regulatory (Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors that influence the replication and spread of T-tropic strains of HIV in vivo and suggest that the use of cell signalling CC-chemokines as therapeutic agents for the purpose of limiting HIV replication in vivo should be approached with caution.
KW  - chemokines
KW  - cytokines
KW  - human diseases
KW  - pathogenesis
KW  - T lymphocytes
KW  - tropisms
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014291&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of the regulatory phosphorylation site in Acanthamoeba myosin IC by using site-directed mutagenesis.
AU  - Wang ZhenYuan
AU  - Wang, F.
AU  - Sellers, J. R.
AU  - Korn, E. D.
AU  - Hammer, J. A., III
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 26
SP  - 15200
EP  - 15205
SN  - 0027-8424
AD  - Wang ZhenYuan: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990801631.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 9064-37-3, 9000-83-3.  Subject Subsets: Protozoology
N2  - The actin-activated ATPase activity of Acanthamoeba myosin IC is stimulated 15- to 20-fold by phosphorylation of Ser-329 in the heavy chain. In most myosins, either glutamate or aspartate occupies this position, which lies within a surface loop that forms part of the actomyosin interface. To investigate the apparent need for a negative charge at this site, Ser-329 was mutated to alanine, asparagine, aspartate or glutamate, and the Flag-tagged wild-type or mutant heavy chain and light chain were co-expressed in baculovirus-infected insect cells. Recombinant wild-type myosin IC was indistinguishable from myosin IC purified from Acanthamoeba as determined by: the dependence of its actin-activated ATPase activity on heavy-chain phosphorylation; the unusual triphasic dependence of its ATPase activity on the concentration of F-actin; its Km for ATP; its ability to translocate actin filaments. The Ala and Asn mutants had the same low actin-activated ATPase activity as unphosphorylated wild-type myosin IC. The Glu mutant, like the phosphorylated wild-type protein, was 16-fold more active than unphosphorylated wild type, and the Asp mutant was 8-fold more active. The wild-type and mutant proteins had the same Km for ATP. Unphosphorylated wild-type protein and the Ala and Asn mutants were unable to translocate actin filaments, whereas the Glu mutant translocated filaments at the same velocity, and the Asp mutant at 50% the velocity, as phosphorylated wild-type proteins. It is concluded that an acidic amino acid can supply the negative charge in the surface loop required for the actin-dependent activities of Acanthamoeba myosin IC in vitro and that the length of the side chain that delivers this charge is important. Sequence data are available in the GenBank database under accession number AF051353.
KW  - actin
KW  - adenosinetriphosphatase
KW  - amino acid sequences
KW  - biochemistry
KW  - myosins
KW  - parasites
KW  - phosphorylation
KW  - Acanthamoeba
KW  - protozoa
KW  - Acanthamoebidae
KW  - Amoebida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - ATPase
KW  - myosin
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801631&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The JC and BK human polyoma viruses appear to be recent introductions to some South American Indian tribes: there is no serological evidence of cross-reactivity with the simian polyoma virus SV40.
AU  - Major, E. O.
AU  - Neel, J. V.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1998///
VL  - 95
IS  - 26
SP  - 15525
EP  - 15530
SN  - 0027-8424
AD  - Major, E. O.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992004044.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref.
N2  - Plasma samples collected during 1966-86 from 425 Amerindians representing 14 tribes from lower Central and northern South America were tested for haemagglutination inhibition antibodies to the human JC polyoma virus and from 369 Amerindians from 13 tribes for haemagglutination inhibition antibodies to the human BK polyoma virus. There is for both viruses highly significant heterogeneity between tribes for the prevalence of serum antibody titres ≥1/40, the pattern of infection suggesting that these 2 viruses only relatively recently have been introduced into some of these tribes. Some of these samples, from populations with no known exposure to the simian polyoma virus SV40, were also tested for antibodies to this virus by using an immunospot assay. None of the samples was found to possess antibodies to SV40. In addition, no significant titres to SV40 were found in a sample of 97 Japanese adults, many of whom had been found to exhibit elevated titres to the JC and BK viruses. It is suggested that these human sera contain significant antibody titres to the human polyoma viruses JC and BK but do not appear to contain either cross-reactive antibodies to SV40 or primary antibodies resulting from SV40 infection.
KW  - antibodies
KW  - cross reaction
KW  - epidemiology
KW  - ethnic groups
KW  - human diseases
KW  - seroprevalence
KW  - simian polyomaviruses
KW  - viral diseases
KW  - Central America
KW  - Japan
KW  - South America
KW  - BK polyomavirus
KW  - JC polyomavirus
KW  - man
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - JC virus
KW  - Polyomavirus hominis 1
KW  - simian polyomavirus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004044&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain.
AU  - Smith, J. D.
AU  - Kyes, S.
AU  - Craig, A. G.
AU  - Fagan, T.
AU  - Hudson-Taylor, D.
AU  - Miller, L. H.
AU  - Baruch, D. I.
AU  - Newbold, C. I.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1998///
VL  - 97
IS  - 1/2
SP  - 133
EP  - 148
SN  - 0166-6851
AD  - Smith, J. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990801974.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Protozoology
N2  - The A4VAR is a variant Plasmodium falciparum antigen expressed by a clonal line that binds CD36 and intercellular adhesion molecule 1 (ICAM-1). The extracellular domain coded by the A4var gene was cloned and sequenced. To probe the relationship between A4var expression and parasite adhesion to ICAM-1, var messenger RNA and protein expression were analysed in an enriched population of A4 parasites that displayed higher ICAM-1 binding. By Northern analyses, A4var was the predominant var message and antisera raised against a recombinant A4VAR protein reacted with the majority of infected erythrocytes, reinforcing previous conclusions that A4VAR binds ICAM-1. A4VAR contains 5 Duffy-binding like (DBL) domains and 2 cysteine-rich interdomain regions (CIDR) domains. DBL and CIDR domains from A4VAR were expressed in mammalian cells to determine which regions mediate binding to CD36 and ICAM-1. Using several different binding assays, the A4VAR CIDR1 was the only domain found to bind CD36. In contrast, the same assays were unable to identify the ICAM-1 binding domain in A4VAR. This is the first time that each of the DBL and CIDR domains from a P. falciparum erythrocyte membrane protein 1 (PfEMP1) have been systematically expressed and tested for binding. The results confirm that CIDR1 is sufficient to bind CD36 without any apparent contribution from other domains. Nucleotide sequence data have been submitted to the EMBL, GenBank and DDLJB databases under the accession number L42244.
KW  - antigens
KW  - binding proteins
KW  - biochemistry
KW  - cell membranes
KW  - clones
KW  - cytoadherence
KW  - erythrocytes
KW  - gene expression
KW  - genes
KW  - host parasite relationships
KW  - messenger RNA
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - variant surface glycoproteins
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - biochemical genetics
KW  - blood red cells
KW  - carrier proteins
KW  - cell adhesion
KW  - DNA sequences
KW  - immunogens
KW  - intercellular adhesion molecule 1
KW  - mRNA
KW  - parasite host relationships
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801974&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary sources of nutrients among US adults, 1989 to 1991.
AU  - Subar, A. F.
AU  - Krebs-Smith, S. M.
AU  - Cook, A.
AU  - Kahle, L. L.
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
Y1  - 1998///
VL  - 98
IS  - 5
SP  - 537
EP  - 547
SN  - 0002-8223
AD  - Subar, A. F.: National Cancer Institute, Applied Research Branch, 6130 Executive Blvd, MSC 7344, EPN 313, Bethesda, MD 20892-7344, USA.
N1  - Accession Number: 19991408650.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Human Nutrition; Potatoes
N2  - To identify major food sources of 27 nutrients and dietary constituents for US adults, single 24-h dietary recalls were used to assess intakes. From 3970 individual foods reported, 112 groups were created on the basis of similarities in nutrient content or use. Food mixtures were disaggregated using the US Department of Agriculture (USDA) food grouping system. A nationally representative sample of adults aged 19 years or older (n=10 638) from USDA's 1989-91 Continuing Survey of Food Intakes by Individuals. For each of 27 dietary components, the contribution of each food group to intake was obtained by summing the amount provided by the food group for all respondents and dividing by total intake from all food groups for all respondents. This article updates previous work and is, to the authors' knowledge, the first to provide such data for carotenes, vitamin B-12, magnesium, and copper. Beef, yeast bread, poultry, cheese, and milk were among the top 10 sources of energy, fat, and protein. The following other major sources also contributed more than 2% to energy intakes: carbohydrate: yeast bread, soft drinks/soda, cakes/cookies/quick breads/doughnuts, sugars/syrups/jams, potatoes (white), ready-to-eat cereal, and pasta; protein: pasta; and fat: margarine, salad dressings/mayonnaise, and cakes/ cookies/quick breads/doughnuts. Ready-to-eat cereals, primarily because of fortification, were among the top 10 food sources for 18 of 27 nutrients. These analyses are the most current regarding food sources of nutrients and, because of disaggregation of mixtures, provide a truer picture of contributions of each food group.
KW  - adults
KW  - diet studies
KW  - foods
KW  - nutrients
KW  - sources
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991408650&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection.
AU  - Sloand, E. M.
AU  - Maciejewski, J. P.
AU  - Sato, T.
AU  - Bruny, J.
AU  - Kumar, P.
AU  - Kim, S.
AU  - Weichold, F. F.
AU  - Young, N. S.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 101
IS  - 1
SP  - 195
EP  - 201
SN  - 0021-9738
AD  - Sloand, E. M.: Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19982004743.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 9068-38-6. 
N2  - The role of interleukin-converting enzyme (ICE) in mediating the increased susceptibility of CD4+ lymphocytes from HIV-1-infected patients to apoptosis was investigated. ICE mRNA was present in T cells from both HIV-1-infected patients (n=40) and controls. Active ICE proteins, p10 and p20, were demonstrated by immunoblot in lymphocytes from HIV-1-infected patients and in normal lymphocytes after treatment with Fas agonist, CH11 monoclonal antibody. Cocultivation of lymphocytes from HIV-1-infected persons with Fas antagonist, antibody ZB4, resulted in decreased expression of ICE protein in lymphocytes from HIV-infected patients, and decreased apoptosis. Similar effects were obtained when cells were treated with synthetic ICE inhibitors, which blocked apoptosis in response to Fas triggering. When CD4+ and CD8+ cells were sorted by flow cytometry and analysed by reverse transcriptase PCR, ICE mRNA was present in both CD8- and CD4+ cells. However, flow cytometric analysis of lymphocytes with intracellular staining for ICE demonstrated ICE protein in the CD4+ but not the CD8+ cell fraction derived from blood of HIV-1-infected patients. These data suggest that activation of ICE occurs in vivo in CD4+ lymphocytes from HIV-1-infected individuals, and may account for the increased susceptibility of CD4+ cells to apoptosis.
KW  - acquired immune deficiency syndrome
KW  - antibodies
KW  - apoptosis
KW  - culture techniques
KW  - enzymes
KW  - flow cytometry
KW  - HIV-1 infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunoblotting
KW  - immunopathology
KW  - interleukin 1
KW  - messenger RNA
KW  - pathogenesis
KW  - patients
KW  - reverse transcriptase
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - interleukin-converting enzyme
KW  - mRNA
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A phase I/II study of the protease inhibitor ritonavir in children with human immunodeficiency virus infection.
AU  - Mueller, B. U.
AU  - Nelson, R. P., Jr.
AU  - Sleasman, J.
AU  - Zuckerman, J.
AU  - Heath-Chiozzi, M.
AU  - Steinberg, S. M.
AU  - Balis, F. M.
AU  - Brouwers, P.
AU  - Hsu, A.
AU  - Saulis, R.
AU  - Sei, S.
AU  - Wood, L. V.
AU  - Zeichner, S.
AU  - Katz, T. T. K.
AU  - Higham, C.
AU  - Aker, D.
AU  - Edgerly, M.
AU  - Jarosinski, P.
AU  - Serchuck, L.
AU  - Whitcup, S. M.
AU  - Pizzuti, D.
AU  - Pizzo, P. A.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1998///
VL  - 101
IS  - 3
SP  - 335
EP  - 343
SN  - 0031-4005
AD  - Mueller, B. U.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland.
N1  - Accession Number: 19992000040.  Publication Type: Journal Article.  Language: English.  Registry Number: 69655-05-6, 63231-63-0, 30516-87-1. 
N2  - Ritonavir, a potent antiretroviral protease inhibitor, has been approved for the treatment of adults and children with human immunodeficiency virus (HIV) infection. In a phase I/II study, we assessed the safety, tolerability, and pharmacokinetic profile of the oral solution of ritonavir in HIV-infected children and studied the preliminary antiviral and clinical effects. HIV-infected children between 6 months and 18 years of age were eligible. Four dose levels of ritonavir oral solution (250, 300, 350, and 400 mg/m² given every 12 hours) were evaluated in two age groups (≤2 years, &gt;2 years). Ritonavir was administered alone for the first 12 weeks and then in combination with zidovudine and/or didanosine. Clinical and laboratory parameters were monitored every 2 to 4 weeks. A total of 48 children (median age, 7.7 years; range, 0.5 to 14.4 years) were included in this analysis. Dose-related nausea, diarrhoea, and abdominal pain were the most common toxicities and resulted in discontinuation of ritonavir in 7 children. Ritonavir was well absorbed at all dose levels, and plasma concentrations reached a peak 2 to 4 hours after a dose. CD4 cells counts increased by a median of 79 cells/mm³ after 4 weeks of monotherapy and were maintained throughout the study. Plasma HIV RNA decreased by 1 to 2 log10 copies/mL within 4 to 8 weeks of ritonavir monotherapy, and this level was sustained in patients enrolled at the highest dose level of 400 mg/m² for the 24-week period. The oral solution of ritonavir has potent antiretroviral activity as a single agent and is relatively well tolerated by children when administered alone or in combination with zidovudine or didanosine.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - blood plasma
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - children
KW  - clinical aspects
KW  - concentration
KW  - diarrhoea
KW  - didanosine
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - laboratories
KW  - patients
KW  - proteinase inhibitors
KW  - proteinases
KW  - RNA
KW  - safety
KW  - treatment
KW  - zidovudine
KW  - man
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - AZT
KW  - CD4
KW  - CD4+ cells
KW  - clinical picture
KW  - diarrhea
KW  - dideoxyinosine
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - plasma (blood)
KW  - protease inhibitors
KW  - proteases
KW  - ribonucleic acid
KW  - scouring
KW  - T4 lymphocytes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Occupational Health and Safety (VV900) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Virulence of catalase-deficient Aspergillus nidulans in p47phox-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease.
AU  - Chang, Y. C.
AU  - Segal, B. H.
AU  - Holland, S. M.
AU  - Miller, G. F.
AU  - Kown-Chung, K. J.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 101
IS  - 9
SP  - 1843
EP  - 1850
SN  - 0021-9738
AD  - Chang, Y. C.: Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201886.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 9001-05-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - To test the role of pathogen-derived catalase in chronic granulomatous disease (CGD) directly, isogenic strains of A. nidulans were generated in which one or both of the catalase genes (catA and catB), were deleted. It was hypothesized that catalase-negative mutants would be less virulent than the wild-type strain in experimental animal models. CGD mice were produced by disruption of the p47phox gene, which encodes the 47-kDa subunit of the NADPH oxidase. Wild-type A. nidulans inoculated intranasally caused fatal infection in CGD mice, but did not cause disease in wild-type littermates. Wild-type A. nidulans and the catA, catB and catA/catB mutants were equally virulent in CGD mice. Histopathological studies of fatally infected CGD mice showed widely distributed lesions in the lungs regardless of the presence or absence of the catA and catB genes. Similar to the CGD model, catalase-deficient A. nidulans was highly virulent in cortisone-treated BALB/c mice. These results indicated that catalases do not play a significant role in pathogenicity of A. nidulans in p47phox-/- mice.
KW  - aspergillosis
KW  - catalase
KW  - enzymes
KW  - experimental infections
KW  - genes
KW  - genetics
KW  - immunological diseases
KW  - infections
KW  - pathogenicity
KW  - susceptibility
KW  - virulence
KW  - Emericella nidulans
KW  - mice
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Emericella
KW  - Aspergillus nidulans
KW  - erythrocyte catalase
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201886&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic Pima Indians are related to glycogen synthase fractional activity in cultured myoblasts.
AU  - Mott, D. M.
AU  - Pratley, R. E.
AU  - Bogardus, C.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 101
IS  - 10
SP  - 2251
EP  - 2256
SN  - 0021-9738
AD  - Mott, D. M.: Clinical Diabetes & Nutrition Section, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19981410885.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 50-99-7, 9014-56-6, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Glycogen synthase fractional activity (GSFA) was measured in cultured myoblasts from 21 Pima Indians (12 men and 9 women aged 30±6 years) characterized in vivo using indirect calorimetry and a euglycaemic hyperinsulinaemic clamp. Basal GSFA in cultured muscle cells was inversely correlated with postabsorptive respiratory quotient of the muscle donors (r = -0.66, P=0.001) and with in vivo high dose insulin-stimulated glucose storage rates (r = 0.47, P=0.04). It is concluded that the postabsorptive respiratory quotients and insulin-mediated glucose storage rates in vivo share a common regulatory mechanism with GSFA in cultured myoblasts. Abnormal regulation of glycogen synthase phosphorylation state may be an intrinsic defect in skeletal muscle associated with obesity and insulin resistance.
KW  - blood sugar
KW  - cell cultures
KW  - diabetes
KW  - enzymes
KW  - ethnic groups
KW  - glucose
KW  - glucose tolerance
KW  - glycogen (starch) synthase
KW  - in vitro
KW  - insulin
KW  - metabolism
KW  - obesity
KW  - respiratory quotient
KW  - skeletal muscle
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood glucose
KW  - blood sugar tolerance
KW  - dextrose
KW  - fatness
KW  - glucose in blood
KW  - glycogen synthase
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981410885&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mutation in the signal-transducing chain of the interferon-γ receptor and susceptibility to mycobacterial infection.
AU  - Dorman, S. E.
AU  - Holland, S. M.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 101
IS  - 11
SP  - 2364
EP  - 2369
SN  - 0021-9738
AD  - Dorman, S. E.: Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886, USA.
N1  - Accession Number: 19982010844.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9008-11-1.  Subject Subsets: Public Health
KW  - bacterial diseases
KW  - case reports
KW  - clinical aspects
KW  - disseminated infections
KW  - human diseases
KW  - immune response
KW  - immunocompromised hosts
KW  - interferon
KW  - mutations
KW  - mycobacterial diseases
KW  - receptors
KW  - Maryland
KW  - USA
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium avium
KW  - Mycobacterium fortuitum
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - clinical picture
KW  - immunity reactions
KW  - immunological reactions
KW  - mycobacterial infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010844&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A phase I/II study of the protease inhibitor indinavir in children with HIV infection.
AU  - Mueller, B. U.
AU  - Sleasman, J.
AU  - Nelson, R. P. Jr
AU  - Smith, S.
AU  - Deutsch, P. J.
AU  - Ju, W.
AU  - Steinberg, S. M.
AU  - Balis, F. M.
AU  - Jarosinski, P. F.
AU  - Brouwers, P.
AU  - Mistry, G.
AU  - Winchell, G.
AU  - Zwerski, S.
AU  - Sei, S.
AU  - Wood, L. V.
AU  - Zeichner, S.
AU  - Pizzo, P. A.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1998///
VL  - 102
IS  - 1
SP  - 101
EP  - 109
SN  - 0031-4005
AD  - Mueller, B. U.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19982012304.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Registry Number: 63231-63-0, 30516-87-1, 150378-17-9. 
N2  - Three dose levels (250 mg/m², 350 mg/m², and 500 mg/m² per dose given orally every 8 h) were evaluated in 2 age groups (&lt;12 years and ≥12 years). Indinavir was initially administered as monotherapy and then in combination with zidovudine and lamivudine after 16 weeks. Fifty four HIV-infected children (ages 3.1 to 18.9 years) were enrolled. The indinavir free-base suspension was less bioavailable than the dry-filled capsule formulation, and therapy was changed to capsules in all children. Haematuria was the most common side effect, occurring in 7 (13%) children, and associated with nephrolithiasis in 1 patient. The combination of indinavir, lamivudine, and zidovudine was well tolerated. The median CD4+ cell count increased after 2 weeks of indinavir monotherapy by 64 cells/mm³, and this was sustained at all dose levels. Plasma ribonucleic acid levels decreased rapidly in a dose-dependent way, but increased toward baseline after a few weeks of indinavir monotherapy. Indinavir dry-filled capsules are relatively well tolerated by children with HIV infection, although haematuria occurs at higher doses. Future studies need to evaluate the efficacy of indinavir when combined de novo with zidovudine and lamivudine.
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - children
KW  - clinical trials
KW  - combination therapy
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - indinavir
KW  - leukocyte count
KW  - proteinase inhibitors
KW  - RNA
KW  - safety
KW  - toxicity
KW  - treatment
KW  - zidovudine
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - CD4+ cells
KW  - cell count
KW  - chemotherapy
KW  - combined modality therapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - multimodal treatment
KW  - protease inhibitors
KW  - ribonucleic acid
KW  - T4 lymphocytes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012304&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro.
AU  - Oliva, A.
AU  - Kinter, A. L.
AU  - Vaccarezza, M.
AU  - Rubbert, A.
AU  - Catanzaro, A.
AU  - Moir, S.
AU  - Monaco, J.
AU  - Ehler, L.
AU  - Mizell, S.
AU  - Jackson, R.
AU  - Li YueXia
AU  - Romano, J. W.
AU  - Fauci, A. S.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 102
IS  - 1
SP  - 223
EP  - 231
SN  - 0021-9738
AD  - Oliva, A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC-1576, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982012271.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref.
N2  - Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES (regulated on activation, normal T cell expressed and secreted), which are the natural ligands of the CC-chemokine receptor CCR5, inhibit replication of MT-2-negative strains of HIV-1 by interfering with the ability of these strains to utilize CCR5 as a coreceptor for entry in CD4+ cells. This study investigates the capacity of natural killer (NK) cells isolated from HIV-infected individuals to produce CC-chemokines and to suppress HIV replication in autologous, endogenously infected cells as well as to block entry of MT-2-negative HIV into the CD4+ T cell line PM-1. NK cells freshly isolated from HIV-infected individuals had a high number of mRNA copies for MIP-1α and RANTES. NK cells produced significant amounts of RANTES, MIP-1α, and MIP-1β constitutively, in response to stimulation with IL-2 alone and when they were performing their characteristic lytic activity (K562 killing). After CD16 cross-linking and stimulation with IL-2 or IL-15 NK cells produced CC-chemokines to levels comparable to those produced by anti-CD3-stimulated CD8+ T cells. Furthermore, CD16 cross-linked NK cells suppressed (49-97%) viral replication in cocultures of autologous CD8/NK-depleted PBMC to a degree similar to that of PHA or anti-CD3-stimulated CD8+ T cells. In 50% of patients tested, NK-mediated HIV suppression could be abrogated by neutralizing antibodies to MIP-1α, MIP-1β and RANTES; in contrast, CD8+ T cell-mediated suppression was not significantly overcome upon neutralization of CC-chemokines. Supernatants derived from cultures of CD16 cross-linked NK cells stimulated with IL-2 or IL-15 dramatically inhibited entry of a MT-2-negative strain of HIV, BaL, in the CD4+ CCR5+ PM-1 T-cell line. These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms.
KW  - chemokines
KW  - cytokines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - in vitro
KW  - natural killer cells
KW  - replication
KW  - uptake
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012271&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hepatitis C virus infection in the mothers and infants cohort study.
AU  - Granovsky, M. O.
AU  - Minkoff, H. L.
AU  - Tess, B. H.
AU  - Waters, D.
AU  - Hatzakis, A.
AU  - Devoid, D. E.
AU  - Landesman, S. H.
AU  - Rubinstein, A.
AU  - Bisceglie, A. M. di
AU  - Goedert, J. J.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1998///
VL  - 102
IS  - 2
SP  - 355
EP  - 359
SN  - 0031-4005
AD  - Granovsky, M. O.: Division of Cancer Epidemiology and Genetics, Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992000129.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 63231-63-0. 
N2  - The objective was to estimate the hepatitis C virus (HCV) vertical transmission rate, the effect of potential risk factors, and the pattern of HCV antibody response and viraemia in HCV-infected infants. The Mothers and Infants Cohort Study enrolled both human immunodeficiency virus (HIV)-seropositive and HIV-seronegative pregnant women at 5 obstetric clinics in New York City, USA in a prospective cohort study between January 1986 and January 1991. HCV-infected mothers and their 122 offspring were followed up for a minimum of 12 months for evidence of HCV infection as determined by persistent HCV antibodies or detection of HCV RNA by reverse transcription polymerase chain reaction. Comparisons among groups for categorical variables were performed using the Fisher's exact test. Seven (6%; 95% confidence interval, 2%-11%) of the 122 infants were HCV-infected. There was a tendency for increased risk of transmission with maternal viral and obstetrical factors, such as co-infection with HIV (7% vs 4%), high HIV viral load (13% vs 6%), HCV viraemia (8% vs 3%), vaginal delivery (6% vs 0%), and female gender of offspring (8% vs 3%), although none of the associations reached statistical significance. After loss of maternal antibody, HCV antibody seroconversion occurred at a mean age of 26 months in 3 HIV-co-infected infants compared with 7 months of age in 4 HCV-infected HIV-negative infants. Serial samples showed that HCV RNA persisted in 6 infants for at least 18 to 54 months. It is concluded that this study is in accordance with other studies that have shown low overall HCV vertical transmission risk and a trend toward higher risk with maternal risk factors such as HIV-co-infection or HCV viraemia. A delay in infant HCV antibody response may be associated with HIV co-infection although larger studies are needed to confirm these findings.
KW  - antibodies
KW  - detection
KW  - hepatitis C
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - infection
KW  - maternal antibodies
KW  - maternal transmission
KW  - mothers
KW  - polymerase chain reaction
KW  - pregnancy
KW  - risk factors
KW  - RNA
KW  - seroconversion
KW  - statistics
KW  - transcription
KW  - transmission
KW  - vertical transmission
KW  - women
KW  - New York
KW  - USA
KW  - hepatitis C virus
KW  - man
KW  - viruses
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - DNA transcription
KW  - gestation
KW  - human immunodeficiency virus
KW  - mother to child transmission
KW  - PCR
KW  - ribonucleic acid
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000129&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes.
AU  - Ueda, H.
AU  - Howard, O. M. Z.
AU  - Grimm, M. C.
AU  - Su ShaoBo
AU  - Gong WangHua
AU  - Evans, G.
AU  - Ruscetti, F. W.
AU  - Oppenheim, J. J.
AU  - Wang JiMing
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 102
IS  - 4
SP  - 804
EP  - 812
SN  - 0021-9738
AD  - Ueda, H.: Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Room 31-40, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982013233.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
N2  - Monocytes preincubated with gp41 of the MN strain showed markedly reduced binding, calcium mobilization, and chemotaxis in response to a variety of chemokines as well as to the bacterial peptide fMLP. This generalized inhibition of monocyte activation by chemoattractants required the presence of CD4, since the effect of gp41 was only observed in CD4+ monocytes and in HEK293 cells cotransfected with chemokine receptors and an intact CD4, but not a CD4 lacking its cytoplasmic domain. Confocal microscopy showed that gp41 caused internalization of CXCR4 in HEK293 cells provided they were also cotransfected with intact CD4. In addition, pretreatment of monocytes with protein kinase C inhibitors partially reversed the inhibitory effect of gp41. Thus, gp41, which had not previously been implicated as interacting with HIV-1 fusion cofactors, downregulates chemoattractant receptors on monocytes by a CD4-dependent pathway.
KW  - chemokines
KW  - chemotaxis
KW  - cytokines
KW  - envelope protein gp41
KW  - human diseases
KW  - monocytes
KW  - pathogenesis
KW  - receptors
KW  - suppression
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - gp41
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013233&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary sources of nutrients among US children, 1989-1991.
AU  - Subar, A. F.
AU  - Krebs-Smith, S. M.
AU  - Cook, A.
AU  - Kahle, L. L.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1998///
VL  - 102
IS  - 4
SP  - 913
EP  - 923
SN  - 0031-4005
AD  - Subar, A. F.: National Cancer Institute, Applied Research Branch, Bethesda, Maryland, USA.
N1  - Accession Number: 19981417763.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 50-81-7, 59-30-3, 7439-89-6, 68-26-8, 7440-66-6.  Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts; Potatoes
N2  - 24-h dietary recalls were collected from a nationally representative sample of children (n=4008; 2 to 18 years old) from the US Department of Agriculture's 1989-1991 Continuing Survey of Food Intakes by Individuals. For each of 16 dietary constituents, the contribution of each of 113 food groups was obtained by summing the amount provided by the food group for all individuals and dividing by total intake from all food groups for all individuals. Milk, yeast bread, cakes/cookies/quick breads/doughnuts, beef and cheese were among the top 10 sources of energy, fat and protein. Many of the top 10 sources of carbohydrate (yeast bread, soft drinks/sodas, milk, ready-to-eat cereal, cakes/cookies/quick breads/doughnuts, sugars/syrups/jams, fruit drinks, pasta, white potatoes); protein (poultry, ready-to-eat cereal, pasta); and fat (potato chips/corn chips/popcorn) also contributed &gt;2% each to energy intakes. Ready-to-eat cereal was among the top contributors to folate, vitamin A, vitamin C, iron and zinc intakes. Fruit drinks, containing little juice, contributed ~14% of total vitamin C intakes. It was concluded that fortified foods were influential contributors to many vitamins and minerals. Low nutrient-dense foods were major contributors to energy, fats and carbohydrate. This compromises the intake of more nutritious foods and may impede compliance with current dietary guidance.
KW  - ascorbic acid
KW  - carbohydrates
KW  - cereal products
KW  - children
KW  - diet
KW  - diet studies
KW  - energy intake
KW  - fat
KW  - folic acid
KW  - foods
KW  - fortification
KW  - guidelines
KW  - iron
KW  - protein
KW  - retinol
KW  - trace elements
KW  - vitamins
KW  - zinc
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - folacin
KW  - folate
KW  - microelements
KW  - recommendations
KW  - saccharides
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Diet Studies (VV110) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1.
AU  - Moriuchi, M.
AU  - Moriuchi, H.
AU  - Turner, W.
AU  - Fauci, A. S.
JO  - Journal of Clinical Investigation
JF  - Journal of Clinical Investigation
Y1  - 1998///
VL  - 102
IS  - 8
SP  - 1540
EP  - 1550
SN  - 0021-9738
AD  - Moriuchi, M.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19992000718.  Publication Type: Journal Article.  Language: English.  Number of References: 83 ref.
N2  - Whether exposure of macrophages to bacterial products impacts the susceptibility of these cells to HIV-1 of different cellular tropisms was examined. it is demonstrated that (1) macrophages exposed to bacterial cell wall components such as lipopolysaccharide (LPS) (Gram-negative rods), lipoteichoic acid (Gram-positive cocci), and lipoarabinomannan (Mycobacteria) become highly susceptible to T cell (T)-tropic HIV-1 (which otherwise poorly replicate in macrophages) and variably susceptible to macrophage (M)-tropic HIV-1; (2) LPS-stimulated macrophages secrete a number of soluble factors (i.e., chemokines, interferon, and proinflammatory cytokines) that variably affect HIV infection of macrophages, depending on the virus phenotype in question; and (3) LPS-stimulated macrophages express CCR5 (a major coreceptor for M-tropic HIV-1) at lower levels and CXCR4 (a major coreceptor for T-tropic HIV-1) at higher levels compared with unstimulated macrophages. It is hypothesized that a more favourable environment for T-tropic HIV-1 and a less favourable or even unfavourable environment for M-tropic HIV-1 secondary to exposure of macrophages to those bacterial products may accelerate a transition from M- to T-tropic viral phenotype, which is indicative of disease progression.
KW  - bacterial products
KW  - exposure
KW  - macrophages
KW  - pathogenesis
KW  - susceptibility
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000718&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome.
AU  - Termanini, B.
AU  - Gibril, F.
AU  - Sutliff, V. E.
AU  - Fang Yu
AU  - Venzon, D. J.
AU  - Jensen, R. T.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1998///
VL  - 104
IS  - 5
SP  - 422
EP  - 430
SN  - 0002-9343
AD  - Termanini, B.: Digestive Diseases Branch, National Institute of Diabetes, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19981412734.  Publication Type: Journal Article.  Language: English.  Number of References: 68 ref. Registry Number: 9000-83-3, 68-19-9.  Subject Subsets: Human Nutrition
N2  - This study examined whether long-term treatment with omeprazole (a H+-K+-adenotriphosphatase (ATPase) inhibitor) alters serum vitamin B12 concentrations in patients with Zollinger-Ellison syndrome. 131 consecutive patients treated with either omeprazole (n=111) or histamine H2-receptor antagonists (n=20) were recruited. Serum vitamin B12 and folate concentrations and complete blood counts were determined after acid secretion had been controlled for at least 6 months. These studies were repeated yearly. Serum vitamin B12 and folate concentrations were correlated with the type of antisecretory drug and the extent of inhibition of acid secretion. The mean duration of omeprazole treatment was 4.5 years, and for H2-receptor antagonists 10 years. Vitamin B12 concentrations, but not serum folate concentrations or any haematological parameter, were lower (P=0.03) in patients treated with omeprazole, especially those with omeprazole-induced sustained hyposecretion (P=0.0014) or complete achlorhydria (P&lt;0.0001). In 68 patients with 2 determinations at least 5 years apart, vitamin B12 concentrations decreased (30%; P=0.001) only in patients rendered achlorhydric. The duration of omeprazole treatment was inversely correlated with vitamin B12 concentrations (P=0.013), but not folate concentrations. Eight patients (6%) developed subnormal B12 concentrations during follow-up. It was concluded that long-term omeprazole treatment leads to significant decreases in serum vitamin B12 but not folate concentrations. These results suggest patients with Zollinger-Ellison syndrome treated with H+-K+-ATPase inhibitors should have their serum vitamin B12 concentrations monitored. Furthermore, these results raise the possibility that other patients treated chronically with H+-K+-ATPase inhibitors may develop B12 deficiency.
KW  - adenosinetriphosphatase
KW  - cyanocobalamin
KW  - drug therapy
KW  - gastric acid
KW  - inhibition
KW  - nutritional state
KW  - patients
KW  - serum
KW  - therapy
KW  - vitamin B12
KW  - Zollinger-Ellison syndrome
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ATPase
KW  - chemotherapy
KW  - cobalamin
KW  - nutritional status
KW  - therapeutics
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412734&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A randomized comparison of fluconazole with amphotericin B as empiric anti-fungal agents in cancer patients with prolonged fever and neutropenia.
AU  - Malik, I. A.
AU  - Moid, I.
AU  - Aziz, Z.
AU  - Khan, S.
AU  - Suleman, M.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1998///
VL  - 105
IS  - 6
SP  - 478
EP  - 483
SN  - 0002-9343
AD  - Malik, I. A.: Department of Medical Oncology, National Cancer Institute, Karachi, Pakistan.
N1  - Accession Number: 19991200438.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 1397-89-3, 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - A total of 106 patients from Pakistan [date not given] with absolute neutropenia (≤500 cells µl) and persistent fever of undetermined origin (&gt;38°C) despite 1 week of broad-spectrum antibiotic therapy were randomly assigned to receive either fluconazole 400 mg orally daily or amphotericin B 0.5 mg/kg daily. Patients with obvious invasive fungal infections were excluded, as were those with abnormal renal or hepatic function. Success was defined as defervescence with the initially assigned antifungal regimen without development of clinically evident invasive fungal infection. Six patients were excluded from the analysis, mostly because they did not have severe neutropenia. 48 patients received amphotericin B and 52 received fluconazole. Baseline clinical characteristics and laboratory parameters as well as duration of neutropenia (7.7 vs. 6.9 days), duration of fever (7.8 vs. 8.1 days) and duration of hospitalization (10.4 vs. 8.3 days) were similar between those receiving amphotericin and fluconazole. Treatment success rates and mortality rates were similar in the 2 groups: 22 (46%) patients in the amphotericin group and 29 (56%) in the fluconazole group responded successfully to therapy (P=0.3), whereas 16 (33%) patients in the amphotericin group and 14 (27%) in the fluconazole group died during hospitalization (P=0.5). Adverse events such as chills and fever (4 vs. 1), bronchospasm (2 vs. 0), severe hypokalaemia (25 vs. 12) and nephrotoxicity (9 vs. 3) were more frequently observed in patients receiving amphotericin. Adverse prognostic factors included prolonged duration of neutropenia and pneumonia. It is concluded that fluconazole is an equally effective but less toxic alternative to amphotericin B as empiric antifungal therapy in cancer patients with prolonged fever and neutropenia.
KW  - adverse effects
KW  - amphotericin B
KW  - efficacy
KW  - fluconazole
KW  - human diseases
KW  - immunocompromised hosts
KW  - mycoses
KW  - neoplasms
KW  - neutropenia
KW  - opportunistic infections
KW  - predisposition
KW  - prophylaxis
KW  - Pakistan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - adverse reactions
KW  - cancers
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - 2,3,7,8-tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident.
AU  - Landi, M. T.
AU  - Consonni, D.
AU  - Patterson, D. G., Jr.
AU  - Needham, L. L.
AU  - Lucier, G.
AU  - Brambilla, P.
AU  - Cazzaniga, M. A.
AU  - Mocarelli, P.
AU  - Pesatori, A. C.
AU  - Bertazzi, P. A.
AU  - Caporaso, N. E.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1998///
VL  - 106
IS  - 5
SP  - 273
EP  - 277
SN  - 0091-6765
AD  - Landi, M. T.: Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 USA.
N1  - Accession Number: 19992007323.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into 3 zones (A, B, R) corresponding to decreasing TCDD levels in soil, and a cohort including all residents was enumerated. The population of the surrounding non-contaminated area (non-ABR) was chosen as referent population. Two decades after the accident, plasma TCDD levels were measured in 62 subjects randomly sampled from the highest exposed zones (A and B) and 59 subjects from non-ABR, frequency matched for age, gender and cigarette smoking status. Subjects living in the exposed areas had persistently elevated plasma TCDD levels (range=1.2-89.9 ppt; geometric mean=53.2 and 11.0 ppt for Zone A and Zone B, respectively). Levels significantly decrease by distance from the accident site (P=0.0001), down to general population values (4.9 ppt) in non-ABR, thus validating the original zone classification based on environmental measurements. Women had higher TCDD levels than men in the entire study area (P=0.0003 in Zone B; P=0.007 in non-ABR). This gender difference persists after adjustment for location within the zone, consumption of meat derived from locally raised animals, age, body mass index and smoking. There is no evidence for a gender difference in exposure, so variation in metabolism or elimination due to body fat or hormone-related factors may explain this finding. Elevated TCDD levels in women may contribute to adverse reproductive, developmental and cancer outcomes.
KW  - blood
KW  - contamination
KW  - dioxins
KW  - heterocyclic oxygen compounds
KW  - poisoning
KW  - Italy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - toxicosis
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hexachlorobenzene as a possible major contributor to the dioxin activity of human milk.
AU  - Birgelen, A. P. J. M. van
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1998///
VL  - 106
IS  - 11
SP  - 683
EP  - 688
SN  - 0091-6765
AD  - Birgelen, A. P. J. M. van: National Institute of Environmental Health Sciences, P.O. Box 12233, MD B3-07, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19990404034.  Publication Type: Journal Article.  Language: English.  Number of References: 100 ref. Registry Number: 118-74-1.  Subject Subsets: Human Nutrition; Dairy Science
N2  - A dioxin-like compound is a compound that binds to the aryl hydrocarbon (Ah) receptor, results in dioxin-like effects, and bioaccumulates. These are the 3 factors for including dioxin-like chemicals in the toxic equivalency factor (TEF) concept. Risk assessment of dioxin-like compounds is based on using these TEF. Hexachlorobenzene (HCB) has all 3 features and should therefore be included in the TEF concept. Relative potency values express the potency of a specific compound in comparison to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent dioxin-like compound, with a relative potency value of 1. For the estimation of the total dioxin activity in an environmental biological sample, the TEF value of a compound is multiplied by the concentration in the specific matrix. This results in a certain number of toxic equivalents (TEQ) for this compound. The total of all TEQ in a certain mixture gives the total dioxin activity of this mixture. HCB binds to the Ah receptor approximately 10 000 times less than TCDD. HCB is also about 10 000 times less potent than TCDD based on in vitro cytochrome P4501A induction and porphyrin accumulation. Using a relative potency value of 0.0001, HCB could add 10-60% to the total TEQ in human milk samples in most countries. In a few countries such as Spain, Slovakia, and the Czech Republic, HCB levels in human milk expressed as TEQ could contribute up to a factor of 6 to the total TEQ in comparison to the contribution of polychlorinated dioxins, dibenzofurans, and biphenyls together, i.e. up to a daily intake of approximately 1 ng TEQ/kg for a breast-fed infant. The HCB levels in human milk in these countries are about the same as those in India. Biochemical, immunological, and neurological changes have been observed in breast-fed infants in countries with relatively low TEQ levels in human milk. Based on this information, the author concludes that HCB should be classified as a dioxin-like compound, that more studies are needed to reduce the uncertainty in the estimation of a relative potency value for HCB, and that epidemiological studies should be undertaken in infants breast-fed in countries with high HCB exposure levels. Furthermore, measurements of HCB levels in human and environmental samples in conjunction with other dioxin-like compounds are a prerequisite for estimating the total dioxin activity in these samples.
KW  - breast feeding
KW  - dioxins
KW  - epidemiology
KW  - hexachlorobenzene
KW  - human milk
KW  - infants
KW  - measurement
KW  - polychlorinated biphenyls
KW  - polychlorinated dibenzodioxins
KW  - polychlorinated dibenzofurans
KW  - reviews
KW  - Czech Republic
KW  - India
KW  - Slovakia
KW  - Spain
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - Mediterranean Region
KW  - Southern Europe
KW  - 2,3,7,8-tetrachlorodibenzo-p-dioxin
KW  - aryl hydrocarbon
KW  - breast milk
KW  - HCB
KW  - metrology
KW  - PCBs
KW  - polychlorinated dioxins
KW  - porphyrin
KW  - toxic equivalents
KW  - Milk and Dairy Produce (QQ010) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Comparison of pesticides and other compounds in carpet dust samples collected from used vacuum cleaner bags and from a high-volume surface sampler.
AU  - Colt, J. S.
AU  - Zahm, S. H.
AU  - Camann, D. E.
AU  - Hartge, P.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1998///
VL  - 106
IS  - 11
SP  - 721
EP  - 724
SN  - 0091-6765
AD  - Colt, J. S.: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Boulevard, Room 418, Bethesda, MD 20892-7364, USA.
N1  - Accession Number: 19990505054.  Publication Type: Journal Article.  Language: English.  Number of References: 6 ref. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4, 90-43-7, 63-25-2, 57-74-9, 12789-03-6, 2921-88-2, 72-55-9, 50-29-3, 72-43-5, 87-86-5, 52645-53-1, 114-26-1.  Subject Subsets: Medical & Veterinary Entomology; Weeds
N2  - Epidemiologic studies of the association between residential pesticide use and cancer risk require an assessment of past pesticide exposures. Pesticide levels in carpet dust are believed to reflect long-term pesticide use. Recent epidemiologic studies have found collection of dust samples using the high-volume surface sampler (HVS3) to be expensive and cumbersome. The levels of pesticides and other compounds in dust obtained from subjects' personal used vacuum cleaner bags were compared to that collected by the HVS3 to see if this simpler method could replace the HVS3 in epidemiologic research. The homes of 15 subjects were visited, used bags taken from their vacuum cleaners, and carpet dust samples collected with the HVS3. The samples were analysed for 42 target compounds: 26 pesticides including DDT, DDE, methoxychlor, chlordane, chlopyrifos, propoxur, carbaryl, permethrin, 2-phenylphenol, pentachlorophenol and 2,4-D, 10 polycyclic aromatic hydrocarbons (PAHs), and 6 polychlorinated biphenyl (PCB) congeners using GC/MS in selected ion monitoring mode. The 2 methods agreed in detecting the presence of the target compounds between 80% and 100% of the time. Neither sampling method was consistently more sensitive. The median target compound concentrations were similar, and a paired t-test showed no significant differences. For many compounds, the concentrations of compounds in the HVS3 samples were higher than those in the used bag samples at the upper end of the concentration ranges. However, the Spearman rank correlation coefficients were 0.85 or higher for most compounds, indicating that homes would be ranked similarly using both methods. Overall, there appears to be no clear difference in the quality of the pesticide, PAH, or PCB concentration data for the 2 dust collection methods.
KW  - 2,4-D
KW  - 2-phenylphenol
KW  - aromatic hydrocarbons
KW  - carbamate insecticides
KW  - carbaryl
KW  - chlordane
KW  - chlorpyrifos
KW  - DDE
KW  - DDT
KW  - dwellings
KW  - fungicides
KW  - herbicides
KW  - house dust
KW  - methoxychlor
KW  - organochlorine insecticides
KW  - organophosphorus insecticides
KW  - pentachlorophenol
KW  - permethrin
KW  - pesticide residues
KW  - polychlorinated biphenyls
KW  - propoxur
KW  - pyrethroid insecticides
KW  - (2,4-dichlorophenoxy)acetic acid
KW  - chlorpyrifos-ethyl
KW  - dicophane
KW  - fungistats
KW  - p,p'-dichlorodiphenyldichloroethylene
KW  - PCBs
KW  - vacuum cleaners
KW  - weedicides
KW  - weedkillers
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505054&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein GP120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.
AU  - Liapi, C.
AU  - Takahashi, N.
AU  - Raynaud, F.
AU  - Evain-Brion, D.
AU  - Anderson, W. B.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998///
VL  - 110
IS  - 4
SP  - 332
EP  - 337
SN  - 0022-202X
AD  - Liapi, C.: Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bldg. 37, Room 1E14, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982007764.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 61-19-8, 60-92-4, 9026-43-1. 
N2  - Because treatment of patients with peptide T (an octapeptide sequence found in HIV-1 gp120) has been observed to result in an improvement in the psoriatic condition, studies were initiated to determine if peptide T and gp120 protein treatment of normal and psoriatic human fibroblasts resulted in any changes in protein kinase (PKA) activity. The results indicated that peptide T and gp120 protein may inversely alter the intracellular levels of 8-azido-[32P]cAMP binding to the RI and RII regulatory subunits of PKA, and of PKA activity in susceptible cells. These observed changes in the cyclic AMP-PKA signalling pathway, a biochemical marker for psoriasis, may offer some mechanistic insight into the noted beneficial effects of peptide T treatment, including an improvement in psoriatic lesions.
KW  - acquired immune deficiency syndrome
KW  - AMP
KW  - c-AMP
KW  - envelope protein gp120
KW  - fibroblasts
KW  - glycoproteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - peptides
KW  - protein kinase
KW  - psoriasis
KW  - skin
KW  - skin diseases
KW  - treatment
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adenosine monophosphate
KW  - AIDS
KW  - cyclic adenosine monophosphate
KW  - cyclic AMP
KW  - dermatoses
KW  - dermis
KW  - gp120
KW  - human immunodeficiency virus
KW  - peptide T
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic studies in Borrelia burgdorferi.
AU  - Rosa, P.
AU  - Bono, J.
AU  - Elias, A.
AU  - Errett, J.
AU  - Kupko, J.
AU  - Stevenson, B.
AU  - Taylor, G.
AU  - Tilly, K.
JO  - Wiener Klinische Wochenschrift
JF  - Wiener Klinische Wochenschrift
Y1  - 1998///
VL  - 110
IS  - 24
SP  - 859
EP  - 862
SN  - 0043-5325
AD  - Rosa, P.: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19990505792.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A previously developed method by which DNA without a naturally occurring B. burgdorferi homologue can be introduced into and stably maintained by B. burgdorferi, was exploited to investigate the utility of additional antibiotic resistance markers in B. burgdorferi. The feasibility of specific gene inactivation by allelic exchange is demonstrated.
KW  - genes
KW  - genetic engineering
KW  - inactivation
KW  - transformation
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - genetic manipulation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Growth of infectious and non-infectious B. burgdorferi at different salt concentrations.
AU  - Elias, A.
AU  - Bono, J. L.
AU  - Tilly, K.
AU  - Rosa, P.
JO  - Wiener Klinische Wochenschrift
JF  - Wiener Klinische Wochenschrift
Y1  - 1998///
VL  - 110
IS  - 24
SP  - 863
EP  - 865
SN  - 0043-5325
AD  - Elias, A.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903, South Fourth Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19990505793.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 19 ref. Registry Number: 7647-14-5.  Subject Subsets: Medical & Veterinary Entomology
N2  - The effect of increased osmotic strength of culture media on growth of infectious and non-infectious Borrelia burgdorferi strains B31 and N40 was investigated. Relatively small increases in the NaCl concentration of the medium significantly inhibited growth in infectious as well as non-infectious strains. Growth of low passage, infectious clone B31-4a was more sensitive to increased NaCl concentrations than high passage, non-infectious clone B31-a. Growth of 2 infectious N40 strains, 1 low passage (N40-Lp) and 1 high passage (N40-P31) was more resistant to increased NaCl concentration than growth of infectious B31-4a. It is concluded that osmotic strength is an important physical parameter for growth of B. burgdorferiin vitro and could influence its ability to adapt and to establish an infection within ticks and mammals.
KW  - cell culture
KW  - culture media
KW  - culture techniques
KW  - environmental factors
KW  - growth
KW  - osmotic pressure
KW  - sodium chloride
KW  - strains
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - NaCl
KW  - osmolality
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice.
AU  - Perkins, S. N.
AU  - Hursting, S. D.
AU  - Phang, J. M.
AU  - Haines, D. C.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998///
VL  - 111
IS  - 2
SP  - 292
EP  - 296
SN  - 0022-202X
AD  - Perkins, S. N.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19981414164.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Human Nutrition
N2  - Heterozygous p53-deficient (p53+/-) mice (in which the inactivation of one allele of the p53 tumour suppressor gene increases susceptibility to spontaneous and carcinogen-induced tumour development) and wild-type (WT) litter mates were subjected to a 2-stage skin carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate. Instead of skin carcinomas, the chemical treatment protocol caused ulcerous skin lesions and 89% of mice fed ad libitum died from infection/septicaemia. When WT mice were restricted to 60% of the average energy intake of the respective ad libitum group, only 33% developed such lesions and the energy restricted (ER) mice survived twice as long on average as the ad libitum mice. ER also extended life span in p53+/- mice, but 50% of p53+/- mice subjected to ER still developed skin ulcers and the mean life span was shorter than that seen in WT mice. Differences in response to ER between WT and p53+/- mice may be due to the reduction in p53 gene dosage or dissimilarity in the application of the ER treatment. It is concluded that some of the beneficial effects of ER may need full expression of p53 for complete realization.
KW  - carcinogenesis
KW  - dermatitis
KW  - energy
KW  - energy restricted diets
KW  - intake
KW  - lifespan
KW  - mortality
KW  - neoplasms
KW  - restricted feeding
KW  - skin diseases
KW  - skin lesions
KW  - tumours
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - calorie-restricted diets
KW  - cancers
KW  - death rate
KW  - dermatoses
KW  - tumors
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - No evidence of human herpesvirus 8 infection in patients with paraneoplastic pemphigus, pemphigus vulgaris, or pemphigus foliaceus.
AU  - Cohen, S. S.
AU  - Weinstein, M. D.
AU  - Herndier, B. G.
AU  - Anhalt, G. J.
AU  - Blauvelt, A.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998///
VL  - 111
IS  - 5
SP  - 781
EP  - 783
SN  - 0022-202X
AD  - Cohen, S. S.: Dermatology Branch, National Cancer Institute, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19982014744.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 9007-49-2.  Subject Subsets: Public Health
N2  - In a search for additional human herpesvirus 8 (HHV-8)-associated diseases, patients attending a hospital in Maryland, USA, with paraneoplastic pemphigus, pemphigus vulgaris and pemphigus foliaceus, were studied [date not given]. Using an immunofluorescence assay able to specifically detect antibodies directed against lytically induced HHV-8 antigens, HHV-8 antibodies were not detected in sera from 24 patients with paraneoplastic pemphigus (including 10 with concomitant Castleman's disease) nor from 19 patients with pemphigus vulgaris. Sera from patients with Kaposi's sarcoma and from healthy US blood donors were positive (25 of 26) and negative (none of 20), respectively. In addition, HHV-8 DNA was not found in frozen lesional skin of 5 patients with pemphigus vulgaris and 5 patients with pemphigus foliaceus by nested PCR (lower limit of detection = 10 copies viral DNA per µg total cellular DNA). Finally, tissue sections of lesional skin from 10 patients with pemphigus vulgaris were negative for HHV-8 by in situ hybridization, using probes able to detect both latently and lytically expressed HHV-8 genes in Kaposi's sarcoma tissue. In summary, no evidence of HHV-8 infection was found in all types of pemphigus using a variety of methods. These findings do not support a general role for HHV-8 in skin diseases associated with immunosuppression.
KW  - antibodies
KW  - detection
KW  - DNA
KW  - human diseases
KW  - immunofluorescence
KW  - Kaposi's sarcoma
KW  - pemphigus (skin disease)
KW  - polymerase chain reaction
KW  - serology
KW  - skin diseases
KW  - Maryland
KW  - USA
KW  - human herpesvirus 8
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - deoxyribonucleic acid
KW  - dermatoses
KW  - fluorescent antibody technique
KW  - IFAT
KW  - PCR
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium ookinete development in the mosquito midgut: a case of reciprocal manipulation.
AU  - Shahabuddin, M.
A2  - Hurd, H.
A2  - Lane, R.
A2  - Chappell, L. H.
JO  - Parasitology
JF  - Parasitology
Y1  - 1998///
VL  - 116
SP  - S83
EP  - S93
SN  - 0031-1820
AD  - Shahabuddin, M.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B2-37, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19980506666.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 95 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - Plasmodium ookinete development and its interactions with the Anopheles vector are reviewed. Development to ookinete allows the parasite to escape from the tightly packed blood bolus, to cross the peritrophic matrix, to be protected from the digestive environment of the midgut lumen and to invade the gut epithelium. The success of these activities may depend on the ability of the ookinete to overcome biochemical and physical barriers in the mosquito. Ookinete motility, secretion of chitinase, resistance to digestive enzymes, and recognition and invasion of the midgut epithelium may play crucial roles in the transformation to oocyst. Sporogonic development depends on the outcome of these host-parasite interactions. The study of ookinete development and its relationship with the mosquito gut may lead to the design of novel transmission-blocking strategies.
KW  - development
KW  - developmental stages
KW  - disease transmission
KW  - disease vectors
KW  - epithelium
KW  - host parasite relationships
KW  - interactions
KW  - life history
KW  - midgut
KW  - ookinetes
KW  - parasites
KW  - reviews
KW  - sporogony
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium
KW  - protozoa
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - growth phase
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506666&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Three-dimensional structure of HIV-1 Rev protein filaments.
AU  - Watts, N. R.
AU  - Misra, M.
AU  - Wingfield, P. T.
AU  - Stahl, S. J.
AU  - Cheng NaiQian
AU  - Trus, B. L.
AU  - Steven, A. C.
AU  - Williams, R. W.
JO  - Journal of Structural Biology
JF  - Journal of Structural Biology
Y1  - 1998///
VL  - 121
IS  - 1
SP  - 41
EP  - 52
SN  - 1047-8477
AD  - Watts, N. R.: Bldg 6, Rm B2-34, 6 Center Drive MSC 2727, National Institutes of Health, Bethesda, MD 20892-2717 USA.
N1  - Accession Number: 19982008142.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 63231-63-0. 
N2  - The structure of Rev filaments formed in the absence of RNA was determined. These filaments may be related to the form in which Rev accumulates at the nuclear envelope prior to import. They consist of a 6-start set of helices of molecular dimers, with 31 subunits in 2 turns. Taking into account spectroscopic and other data, a tentative model is proposed, wherein the α-helices in the amino-terminal domain of Rev are in approximate alignment with each other and with the filament axis and are probably located on the inner surface of the filament wall. The carboxy-terminal domain, putatively composed in part of antiparallel beta sheet, may form the smooth outer surface.
KW  - biochemistry
KW  - human diseases
KW  - Rev protein
KW  - RNA
KW  - structure
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - From research to global reality: the micronutrient story.
AU  - Underwood, B. A.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1998///
VL  - 128
IS  - 2
SP  - 145
EP  - 151
SN  - 0022-3166
AD  - Underwood, B. A.: National Eye Institute, National Institute of Health, Bethesda, MD 20814, USA.
N1  - Accession Number: 19991413464.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Subject Subsets: Human Nutrition
N2  - A biographical report of the contribution of E. V. McCollum to micronutrient research is presented.
KW  - history
KW  - nutrition research
KW  - nutritionists
KW  - trace elements
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - microelements
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413464&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - α-Tocopherol concentrations in plasma but not in lipoproteins fluctuate during the menstrual cycle in healthy premenopausal women.
AU  - Lanza, E.
AU  - Forman, M. R.
AU  - Johnson, E. J.
AU  - Muesing, R. A.
AU  - Graubard, B. I.
AU  - Beecher, G. R.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1998///
VL  - 128
IS  - 7
SP  - 1150
EP  - 1155
SN  - 0022-3166
AD  - Lanza, E.: Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 20001409284.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 59-02-9, 57-88-5, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - 12 free-living women, with a confirmed ovulatory cycle, were given a controlled diet for 2 consecutive menstrual cycles. Blood was drawn during the menses, early follicular, late follicular and luteal phases to simultaneously measure serum hormones, plasma lipoproteins and α-tocopherol (A-T) concentrations, and A-T distribution in the lipoprotein fractions. Plasma A-T concentrations were lower during menses than during the luteal phase by ~12% in each controlled diet cycle (P&lt;0.001). Adjustment for serum cholesterol and triglyceride concentrations did not alter these findings. The distributions of A-T in lipoprotein cholesterol fractions were not significantly different by menstrual phase. From 61 to 62% of A-T was concentrated in the LDL fraction, with another 9-14% in HDL2, 17-22% in HDL3 and the remaining 6-8% in VLDL plus IDL. There were no significant differences in lipoprotein cholesterol fractions by menstrual phase, except for a increase (P=0.03) in HDL2 cholesterol from the early follicular to the late follicular phase. Spearman rank correlations from data during the second controlled diet month showed A-T in HDL2 in the late follicular phase was positively correlated with HDL cholesterol in the early follicular (r=0.88), late follicular (r=0.86) and luteal phases (r=0.86) and with luteal apolipoprotein (apo a-1) level (r=0.90), and luteal HDL2 cholesterol (r=0.83). A-T in HDL3 in the early follicular phase was negatively correlated with HDL2 cholesterol (r=-0.96) and apo a-1 (r=-0.85), whereas luteal A-T in HDL3 was correlated with luteal HDL3 cholesterol (r=-0.79). Late follicular A-T in VLDL was positively correlated with early follicular HDL3 cholesterol and late follicular HDL3 cholesterol (r=0.83). Fluctuations of A-T concentrations by phase of the menstrual cycle should be taken into consideration in future research concerning premenopausal women and the risk of chronic disease.
KW  - alpha-tocopherol
KW  - antioxidants
KW  - carotenoids
KW  - cholesterol
KW  - hormones
KW  - lipoproteins
KW  - menstrual cycle
KW  - vitamin E
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - tetraterpenoids
KW  - Human Reproduction and Development (VV060) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001409284&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clinical, pathologic, and immunologic features of human T-lymphotrophic virus type I-associated infective dermatitis in children.
AU  - Grenade, L. la
AU  - Manns, A.
AU  - Fletcher, V.
AU  - Carberry, C.
AU  - Hanchard, B.
AU  - Maloney, E. M.
AU  - Cranston, B.
AU  - Williams, N. P.
AU  - Wilks, R.
AU  - Kang, E. C.
AU  - Blattner, W. A.
JO  - Archives of Dermatology
JF  - Archives of Dermatology
Y1  - 1998///
VL  - 134
IS  - 4
SP  - 439
EP  - 444
SN  - 0003-987X
AD  - Grenade, L. la: Department of Medicine, University of the West Indies, Kingston, Jamaica. Correspondence address [Manns, A.]: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd, Suite 434, Rockville, MD 20892, USA.
N1  - Accession Number: 19982007618.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4. 
N2  - At 2 hospitals in Kingston, Jamaica, consecutive patients older than 1.5 years diagnosed as having infective dermatitis (ID; n=50) and atopic dermatitis (AD; n=35) were enrolled based on clinical findings. The mean ages of patients with ID and AD were 6.9 and 7.8 years, respectively. Histologically, both diseases were predominantly chronic dermatitis with propensity for skin colonization with Staphylococcus aureus and β-haemolytic streptococci; however, the distribution of sites of skin involvement differed. Infection with HTLV-I was the most distinguishing feature among patients with ID, with seropositive results in 100%; only 5 (14%) of the 35 patients with AD had results seropositive for HTLV-I. Infective dermatitis was further characterized by dermatopathic lymphadenitis in 16 (67%) of 24 patients with palpable nodes. Anaemia, lymphocytosis, and low albumin and elevated serum globulin levels were more prevalent among patients with ID. Significant elevations of IgA, IgD, and IgG levels were observed among patients with ID compared with those with AD. However, both patients with AD and those with ID had levels of IgD and IgE elevated above the normal range. T-cell subsets among patients with ID revealed T-cell activation with a high percentage of HLA-DR antigen positivity, elevated CD4+ (2.4 × 109/L) and CD8+ (1.4 × 109/L) cell counts, with an increased CD4/CD8 ratio of 1:73.
KW  - albumins
KW  - antigens
KW  - atopy
KW  - CD4 antigens
KW  - CD8 antigens
KW  - children
KW  - chronic course
KW  - dermatitis
KW  - diagnosis
KW  - differential diagnosis
KW  - human diseases
KW  - IgA
KW  - IgE
KW  - IgG
KW  - immunoglobulins
KW  - laboratories
KW  - leukocyte count
KW  - lymphadenitis
KW  - lymphocyte transformation
KW  - T lymphocytes
KW  - Caribbean
KW  - Jamaica
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Staphylococcus
KW  - Staphylococcus aureus
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Staphylococcaceae
KW  - Bacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Staphylococcus
KW  - America
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - Threshold Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - antigenicity
KW  - bacterium
KW  - CD4
KW  - CD8
KW  - cell count
KW  - gamma-globulins
KW  - HTLV-BLV group
KW  - IgD
KW  - immune globulins
KW  - immunogens
KW  - reagin
KW  - reaginic antibodies
KW  - T cells
KW  - West Indies
KW  - Health Services (UU350) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007618&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV.
AU  - Meng, X. J.
AU  - Halbur, P. G.
AU  - Haynes, J. S.
AU  - Tsareva, T. S.
AU  - Bruna, J. D.
AU  - Royer, R. L.
AU  - Purcell, R. H.
AU  - Emerson, S. U.
JO  - Archives of Virology
JF  - Archives of Virology
Y1  - 1998///
VL  - 143
IS  - 7
SP  - 1405
EP  - 1415
SN  - 0304-8608
AD  - Meng, X. J.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19982214236.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2  - Specific-pathogen-free pigs were inoculated i.v. with swine HEV (4 pigs) or with about 105 monkey infectious doses of 1 of 2 human strains (Sar-55 or Mex-14) of HEV (6 pigs). Serum samples collected from naturally infected pigs were used as the source of swine HEV. Pigs inoculated with serum samples containing swine HEV seroconverted to anti-HEV 4 to 8 weeks after inoculation, and the virus spread to an uninoculated pig housed in the same room. Swine HEV was detected in nasal and rectal swab materials as early as 2 weeks after inoculation and for 4 to 8 weeks thereafter. Viraemia appeared 4 to 6 weeks after inoculation and lasted 1 to 3 weeks. The inoculated pigs appeared clinically normal and serum liver enzymes were not significantly elevated. In contrast, pigs were not infected when inoculated with the human strains of HEV.
KW  - experimental infection
KW  - pathology
KW  - strains
KW  - viraemia
KW  - hepatitis E virus
KW  - man
KW  - pigs
KW  - Hepatitis E-like viruses
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Sus scrofa
KW  - Sus
KW  - Suidae
KW  - Suiformes
KW  - Artiodactyla
KW  - experimental transmission
KW  - hogs
KW  - swine
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982214236&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci.
AU  - Bono, J. L.
AU  - Tilly, K.
AU  - Stevenson, B.
AU  - Hogan, D.
AU  - Rosa, P.
JO  - Microbiology (Reading)
JF  - Microbiology (Reading)
Y1  - 1998///
VL  - 144
IS  - 4
SP  - 1033
EP  - 1044
SN  - 1350-0872
AD  - Bono, J. L.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980504818.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - To elucidate the importance of oligopeptide permease for B. burgdorferi, a chromosomal locus in B. burgdorferi that encodes homologues of all 5 subunits of oligopeptide permease was identified and characterized. B. burgdorferi has multiple copies of the gene encoding the peptide-binding component, OppA; 3 reside at the chromosomal locus and 2 are on plasmids. Northern analyses indicate that each oppA gene is independently transcribed, although the 3 chromosomal oppA genes are also expressed as bi- and tri-cistronic messages. Induction of one of the plasmid-encoded oppA genes was observed following an increase in temperature, which appears to be an important cue for adaptive responses in vivo. The deduced amino acid sequences suggest that all 5 borrelial OppA homologues are lipoproteins, but the protease-resistance of at least one of them in intact bacteria is inconsistent with outer-surface localization. Insertional inactivation of a plasmid-encoded oppA gene demonstrates that it is not essential for growth in culture. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are AF000365 (oppAV), AF000366 (chromosomal opp locus) and AF000948 (oppAIV).
KW  - amino acid sequences
KW  - chromosomes
KW  - genes
KW  - lipoproteins
KW  - molecular genetics
KW  - nucleotide sequences
KW  - plasmids
KW  - temperature
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - oligopeptide permease
KW  - permease
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504818&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi.
AU  - Stevenson, B.
AU  - Casjens, S.
AU  - Rosa, P.
JO  - Microbiology (Reading)
JF  - Microbiology (Reading)
Y1  - 1998///
VL  - 144
IS  - 7
SP  - 1869
EP  - 1879
SN  - 1350-0872
AD  - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA.
N1  - Accession Number: 19990500684.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - A single B. burgdorferi bacterium may contain 6 or more different 32 kb circular plasmids (cp32s). Although these plasmids are homologous throughout much of their sequences, 2 loci were identified at which they can vary significantly. The cp32 plasmids and their relatives each contain 2 adjacent genes, orfC and orf3, that vary in sequence between plasmids found within clones of individual bacteria. The orfC gene product is homologous to proteins involved in partitioning of bacterial plasmids, and the differences at this locus between plasmids may account for their compatibility. The orfC-orf3 loci are located ~5 kb from another variable locus called erp. The orfC-orf3 loci were used as physically linked markers to assess genetic rearrangements in the erp loci; this revealed examples of recombination involving both individual genes and entire erp loci. Recombination of the genes encoding the Erp antigens might contribute to the evasion of the mammalian immune response and could play roles in the establishment and persistence of B. burgdorferi infections in mammalian hosts. The EMBL/GenBank/DDBJ accession numbers for the orfC-orf3 loci of B31 plasmids, cp32-2, cp32-3, cp32-4, cp32-6 and cp32-7 are AF022479-AF022483, respectively.
KW  - antigens
KW  - biotechnology
KW  - genes
KW  - immunity
KW  - loci
KW  - molecular genetics
KW  - nucleotide sequences
KW  - plasmids
KW  - proteins
KW  - recombination
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - DNA sequences
KW  - genetic recombination
KW  - immunogens
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500684&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Use of neural networks to model complex immunogenetic associations of disease: human leukocyte antigen impact on the progression of human immunodeficiency virus infection.
AU  - Ioannidis, J. P. A.
AU  - McQueen, P. G.
AU  - Goedert, J. J.
AU  - Kaslow, R. A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1998///
VL  - 147
IS  - 5
SP  - 464
EP  - 471
SN  - 0002-9262
AD  - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Solar Bldg, Rm 2C31, 6003 Executive Blvd., Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005297.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref.
N2  - Neural networks offer further support to the notion that HIV disease progression may be dependent on complex interactions between different class I and class II alleles and transporters associated with antigen-processing variants. The effect of the current models is of moderate magnitude, and more data as well as other host and pathogen variables may need to be considered to improve the performance of the models. Artificial intelligence methods may complement linear statistical methods for evaluating immunogenetic associations of disease.
KW  - computers
KW  - disease course
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunogenetics
KW  - interactions
KW  - major histocompatibility complex
KW  - statistical analysis
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - histocompatibility complex
KW  - human immunodeficiency virus
KW  - human leukocyte antigen
KW  - statistical methods
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005297&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Direct and indirect estimates of HIV-1 incidence in a high-prevalence population.
AU  - Cleghorn, F. R.
AU  - Jack, N.
AU  - Murphy, J. R.
AU  - Edwards, J.
AU  - Mahabir, B.
AU  - Paul, R.
AU  - O'Brien, T.
AU  - Greenberg, M.
AU  - Weinhold, K.
AU  - Bartholomew, C.
AU  - Brookmeyer, R.
AU  - Blattner, W. A.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1998///
VL  - 147
IS  - 9
SP  - 834
EP  - 839
SN  - 0002-9262
AD  - Cleghorn, F. R.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982013035.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref.
N2  - The authors set out to estimate HIV-1 incidence in a population of heterosexual sexually transmitted disease clinic attendees in Trinidad who had a known high prevalence of HIV-1 subtype B. During 1987-1995, HIV-1 incidence estimates from serial cross-sectional studies of HIV-1 prevalence, passive follow-up of clinic recidivists, modeling of early markers of HIV-1 infection (p24 antigen screening), and a cohort study of seronegative genital ulcer disease cases were compared. Measuring incidence density in the genital ulcer disease cases directly gave the highest estimate, 6.9% per annum. Screening for the detection of early HIV-1 markers yielded an incidence of 5.0% per annum, while estimating incidence from serial cross-sectional prevalence data and clinic recidivists gave estimates of 3.5% and 4.5% per annum, respectively. These results were found to be internally consistent. Indirect estimates of incidence based on prevalence data can give accurate surrogates of true incidence. Within limitations, even crude measures of incidence are robust enough for health planning and evaluation purposes. For planning vaccine efficacy trials, consistent conservative estimates may be used to evaluate populations before targeting them for cohort studies.
KW  - epidemiology
KW  - estimates
KW  - human diseases
KW  - incidence
KW  - sexually transmitted diseases
KW  - Trinidad and Tobago
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Lesser Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - estimations
KW  - human immunodeficiency virus type 1
KW  - sexually transmitted infections
KW  - STDs
KW  - Trinidad & Tobago
KW  - venereal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relation of self-image to body size and weight loss attempts in black women: the CARDIA study.
AU  - Riley, N. M.
AU  - Bild, D. E.
AU  - Cooper, L.
AU  - Schreiner, P.
AU  - Smith, D. E.
AU  - Sorlie, P.
AU  - Thompson, J. K.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1998///
VL  - 148
IS  - 11
SP  - 1062
EP  - 1068
SN  - 0002-9262
AD  - Riley, N. M.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
N1  - Accession Number: 19991402916.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Human Nutrition
N2  - It has been suggested that the prevalence of obesity in black women is high partly because self-image in black women is not strongly dependent on body size. To determine associations between self-image, body size, and dieting behavior among black women, the authors assessed an Appearance Evaluation Subscale (AES) score (range, 1-5), a Body Image Satisfaction (BIS) score (range, 2-11), and reported dieting behaviour in a population-based sample of 1143 black women aged 24-42 years from the fourth follow-up examination (1992-93) of the Coronary Artery Risk Development in Young Adults (CARDIA) Study conducted in the USA. After adjustment for age, education, smoking, and physical activity, women in the lowest, middle, and highest tertiles of body mass index (weight (kg)/height (m)²) had mean AES scores of 3.7, 3.3, and 2.9, respectively (P&lt;0.001), and mean BIS scores of 7.8, 6.7, and 5.9, respectively (P&lt;0.001). After additional control for body mass index as a continuous variable, both AES and BIS scores were inversely related to ever dieting, current dieting, and previous weight loss of 10 pounds (4.5 kg) or more in all tertiles of body mass index. These results suggest that among black women, a higher body mass index is associated with poorer self-image and lower body size satisfaction and that these perceptions may be an avenue to promoting weight control.
KW  - behaviour
KW  - blacks
KW  - body image
KW  - body weight
KW  - ethnic groups
KW  - obesity
KW  - weight reduction
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - behavior
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991402916&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mechanisms of symptom in Bartoszyn´ski's virus model.
AU  - Kim, Y.
JO  - Mathematical Biosciences
JF  - Mathematical Biosciences
Y1  - 1998///
VL  - 153
IS  - 1
SP  - 63
EP  - 78
CY  - New York; USA
PB  - Elsevier Science Inc.
SN  - 0025-5564
AD  - Kim, Y.: National Institutes of Health, 6100 Executive Blvd. 7B13, Rockville, MD 20852, USA.
N1  - Accession Number: 20013181409.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref.
N2  - R. Bartoszyn´ski presented a model describing the growth of rabies virus in a human host after infection by a rabid animal. This paper is concerned with that model. Our main interests are in developing mechanisms of a symptom - how the probability of the occurrence of the symptom is related to the process. Four mechanisms are suggested based on various biological backgrounds. The main variable of interests is the survival time - the time elapsing between initial infection and the occurrence of the symptom. Analytical results about the survival functions induced from the four suggested mechanisms are studied.
KW  - clinical aspects
KW  - disease course
KW  - human diseases
KW  - infection
KW  - mathematical models
KW  - pathogenesis
KW  - rabies
KW  - symptoms
KW  - man
KW  - rabies virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lyssavirus
KW  - Rhabdoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - clinical picture
KW  - disease progression
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Mathematics and Statistics (ZZ100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013181409&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Unconventional therapies for cancer. 5. Vitamins A, C and E.
AU  - Kaegi, E.
JO  - Canadian Medical Association Journal
JF  - Canadian Medical Association Journal
Y1  - 1998///
VL  - 158
IS  - 11
SP  - 1483
EP  - 1488
SN  - 0820-3946
AD  - Kaegi, E.: National Cancer Institute, Canada.
N1  - Accession Number: 19981418495.  Publication Type: Journal Article.  Language: English.  Number of References: 61 ref. Registry Number: 50-81-7, 68-26-8, 1406-18-4.  Subject Subsets: Human Nutrition
KW  - antioxidants
KW  - ascorbic acid
KW  - diet treatment
KW  - neoplasms
KW  - retinol
KW  - treatment
KW  - vitamin E
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - cancers
KW  - diet prescription
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418495&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cutting edge: HIV-1 infection induces a selective reduction in STAT5 protein expression.
AU  - Pericle, F.
AU  - Pinto, L. A.
AU  - Hicks, S.
AU  - Kirken, R. A.
AU  - Sconocchia, G.
AU  - Rusnak, J.
AU  - Dolan, M. J.
AU  - Shearer, G. M.
AU  - Segal, D. M.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 160
IS  - 1
SP  - 28
EP  - 31
SN  - 0022-1767
AD  - Pericle, F.: Bldg 10, Rm 4B17, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982001924.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
N2  - HIV-1 infection is accompanied by qualitative and quantitative defects in CD4+ T lymphocytes. Loss of immune function in HIV patients is usually associated with a profound dysregulation of cytokine production. To investigate whether cytokine signalling defects occur during HIV infection, PHA blasts from healthy human donors were infected with two strains of HIV-1 and screened for the expression of signal transducer and activator of transcription (STAT) proteins used in cytokine signalling. A selective decrease in STAT5B was seen 8 days after infection with the BZ167 dual-tropic HIV isolate, but not with the Ba-L, M-tropic strain. Based on these findings, purified T cells from HIV-infected patients in different stages of disease were also tested for STAT expression; decreases in STAT5A, STAT5B, and STAT1α were observed in all patients. The reduction in STATs seen in vivo and in vitro after HIV infection may contribute to the loss of T cell function in HIV disease.
KW  - cytokines
KW  - donors
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunopathology
KW  - in vitro
KW  - infection
KW  - pathogenesis
KW  - patients
KW  - proteins
KW  - strains
KW  - T lymphocytes
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA transcription
KW  - functions
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001924&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Helminth antigens selectively differentiate unsensitized CD45RA+CD4+ human T cells in vitro.
AU  - Steel, C.
AU  - Nutman, T. B.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 160
IS  - 1
SP  - 351
EP  - 360
SN  - 0022-1767
AD  - Steel, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980804966.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Registry Number: 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology
N2  - To examine the relationship between early exposure to filarial antigen and subsequent immune responsiveness, CD45RA+CD4+ cells from normal unsensitized donors were stimulated in vitro with soluble microfilarial antigen (MfAg) from Brugia malayi in the presence of antigen presenting cells. MfAg alone induced proliferation and IFN-γ and IL-5 production in unsensitized CD45RA+CD4+ cells, demonstrating the ability of filarial antigens to prime naive T cells in the absence of exogenous cytokines and dendritic cells. Adding exogenous cytokine(s) (particularly IL-12 and IL-4) during priming altered the MfAg-specific responses of CD45RA+CD4+ cells as well as subsequent responses to antigen. Priming solely with MfAg led to enhanced IL-5 production following antigen restimulation, suggesting that MfAg preferentially primes for type 2 responses.
KW  - antigens
KW  - cytokines
KW  - helminths
KW  - immune response
KW  - in vitro
KW  - interferon
KW  - interleukin 12
KW  - interleukin 4
KW  - interleukin 5
KW  - microfilariae
KW  - parasites
KW  - T lymphocytes
KW  - Brugia malayi
KW  - Brugia
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenicity
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804966&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infection of mice lacking the common cytokine receptor γ-chain (γc) reveals an unexpected role for CD4+ T lymphocytes in early IFN-γ-dependent resistance to Toxoplasma gondii.
AU  - Scharton-Kersten, T.
AU  - Nakajima, H.
AU  - Yap, G.
AU  - Sher, A.
AU  - Leonard, W. J.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 160
IS  - 6
SP  - 2565
EP  - 2569
SN  - 0022-1767
AD  - Scharton-Kersten, T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980804759.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - Mice lacking the common cytokine receptor γ-chain (γc) gene exhibit defective development of natural killer (NK) cells and CD8+ T cells and greatly diminished production of interferon (IFN)-γ. Because resistance of SCID mice to Toxoplasma gondii requires interleukin (IL)-12-dependent IFN-γ production by NK cells, it was expected that γc-deficient mice would succumb rapidly to the parasite. However, most γc-deficient mice survived the acute phase of T. gondii infection. As in wild-type mice, this resistance required IL-12 and IFN-γ but whereas wild-type mice depleted of CD4+ T cells survived, anti-CD4+ treated γc-deficient mice displayed diminished production of IFN-γ and all succumbed to acute infection. The results indicate a role for CD4+ T lymphocytes in IFN-γ-dependent host defence and also establish SCID and γc-deficient mice as powerful complementary tools for assessing the function of NK versus CD4+ T cells in immunopathophysiological responses.
KW  - cytokines
KW  - disease resistance
KW  - experimental infections
KW  - immune response
KW  - interferon
KW  - interleukin 12
KW  - laboratory animals
KW  - mutants
KW  - natural killer cells
KW  - parasites
KW  - receptors
KW  - T lymphocytes
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - resistance to disease
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804759&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
AU  - Rubbert, A.
AU  - Combadiere, C.
AU  - Ostrowski, M.
AU  - Arthos, J.
AU  - Dybul, M.
AU  - Machado, E.
AU  - Cohn, M. A.
AU  - Hoxie, J. A.
AU  - Murphy, P. M.
AU  - Fauci, A. S.
AU  - Weissman, D.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 160
IS  - 8
SP  - 3933
EP  - 3941
SN  - 0022-1767
AD  - Rubbert, A.: Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 6A02, 10 Center Drive, MSC-1576, Bethesda, MD 20892-1570, USA.
N1  - Accession Number: 19982006881.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref.
N2  - Cells of the dendritic lineage are thought to be among the first cells infected after mucosal exposure to HIV. This study revealed the presence of multiple chemokine receptors on dendritic cells (DCs) that may function as coreceptors for HIV entry. DC effectively used CCR5 for entry of macrophage (M)-tropic isolates. CCR3, the eotaxin receptor, initially identified on eosinophils, is expressed on DCs and may be used as an entry coreceptor by certain dual-tropic strains. CXCR4 was not expressed on DCs, although SDF-1 induced a calcium flux and DCs could be infected by T-cell line (T)-tropic HIV. These findings provide evidence for the presence of a non-CXCR4 SDF-1 receptor on DCs that is used mainly by T-tropic strains of HIV. DCs from individuals homozygous for a 32-bp deletion of the CCR5 gene are also infectable with M-tropic strains of HIV-1, and this infection is inhibited by stromal cell-derived factor (SDF)1, suggesting that this receptor can also be used by M-tropic HIV for entry. Delineation of the spectrum of coreceptor usage on DCs may offer new approaches to interfere with the initiation and propagation of HIV infections.
KW  - cell lines
KW  - chemokines
KW  - cytokines
KW  - dendritic cells
KW  - eosinophils
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - infections
KW  - macrophages
KW  - mucosa
KW  - receptors
KW  - replication
KW  - sexual transmission
KW  - strains
KW  - T lymphocytes
KW  - transmission
KW  - tropisms
KW  - uptake
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - eosinophil leukocytes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mucous membrane
KW  - T cells
KW  - venereal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006881&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-10 regulates liver pathology in acute murine schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.
AU  - Wynn, T. A.
AU  - Cheever, A. W.
AU  - Williams, M. E.
AU  - Hieny, S.
AU  - Caspar, P.
AU  - Kühn, R.
AU  - Müller, W.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 160
IS  - 9
SP  - 4473
EP  - 4480
SN  - 0022-1767
AD  - Wynn, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980805592.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 308079-78-9.  Subject Subsets: Helminthology
N2  - IL-10 gene knockout mice (IL-10T) were used to examine the role of endogenous IL-10 in the down-modulation of hepatic granuloma formation and lymphocyte responses that occurs in chronic infection with Schistosoma mansoni. Although IL-10-deficient animals showed 20 to 30% mortality between 8 and 14 weeks pi, they displayed no alterations in their susceptibility to infection and produced similar numbers of eggs as their wild-type littermates. The IL-10T mice displayed a significant increase in hepatic granuloma size at the acute stage of infection, which was associated with increased IFN-γ, IL-2, IL-1β, and TNF-α mRNA expression in liver and elevated Th1-type cytokine production by lymphoid cells. Despite developing an enhanced Th1-type cytokine response, the IL-10T mice showed no consistent decrease in their Th2-type cytokine profile. Although granulomatous inflammation was enhanced at the acute stage of infection, the livers of IL-10T mice displayed no significant increase in fibrosis and underwent normal immune down-modulation at the chronic stage of infection. Moreover, the down-modulated state could be induced in IL-10T mice by sensitizing the animals to schistosome eggs before infection, further demonstrating that the major down-regulatory mechanism is not dependent upon IL-10. It is concluded that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection.
KW  - acute course
KW  - chronic course
KW  - cytokines
KW  - experimental infections
KW  - granuloma
KW  - helminths
KW  - immune response
KW  - immunopathology
KW  - inflammation
KW  - interferon
KW  - interleukin 1
KW  - interleukin 10
KW  - interleukin 2
KW  - laboratory animals
KW  - liver
KW  - lymphocytes
KW  - mortality
KW  - parasites
KW  - pathology
KW  - susceptibility
KW  - Th1 lymphocytes
KW  - Th2 lymphocytes
KW  - tumour necrosis factor
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - cachectin
KW  - cachexin
KW  - death rate
KW  - gene knockout mice
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - parasitic worms
KW  - severe course
KW  - Strigeida
KW  - T helper cells
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805592&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Demonstration of human T lymphotropic virus type I (HTLV-I) Tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection.
AU  - Kubota, R.
AU  - Kawanishi, T.
AU  - Matsubara, H.
AU  - Manns, A.
AU  - Jacobson, S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 161
IS  - 1
SP  - 482
EP  - 488
SN  - 0022-1767
AD  - Kubota, R.: NINDS, National Institutes of Health, Bldg 10, Rm 5B-16, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982010481.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref.
N2  - These data suggest that high levels of circulating HTLV-I-specific CD8+ T lymphocytes have the potential to produce proinflammatory cytokines and may promote inflammatory responses to HTLV-I in HAM/TSP patients.
KW  - CD8+ lymphocytes
KW  - cytokines
KW  - human diseases
KW  - myelopathy
KW  - pathogenesis
KW  - Tax protein
KW  - tropical spastic paraparesis
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - CD8+ cells
KW  - HTLV-BLV group
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010481&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals.
AU  - Ostrowski, M. A.
AU  - Justement, S. J.
AU  - Catanzaro, A.
AU  - Hallahan, C. A.
AU  - Ehler, L. A.
AU  - Mizell, S. B.
AU  - Kumar, P. N.
AU  - Mican, J. A.
AU  - Chun TaiWook
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 161
IS  - 6
SP  - 3195
EP  - 3201
SN  - 0022-1767
AD  - Ostrowski, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm. 6A11, 10 Center Dr., MSC-1576, Bethesda, MD 20892-1576, USA.
N1  - Accession Number: 19982013724.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref.
N2  - A cross-sectional study was conducted to evaluate the expression of 2 HIV-1 coreceptors, CCR5 and CXCR4, in whole blood samples taken from HIV-1 infected and uninfected individuals. It is demonstrated that CXCR4 on CD4+ and CD8+ T cells, and CD14+ monocytes is significantly down-regulated, and CCR5 expression on CD4+ T cells is up-regulated in HIV-infected individuals compared with uninfected controls. Coreceptor expression correlated with the level of cellular activation in vivo in both HIV-infected and uninfected individuals, with CXCR4 being expressed predominantly on quiescent (HLA-DR-) T cells and CCR5 being expressed predominantly on activated (HLA-DR+) T cells. Lower expression of CXCR4 and higher expression of CCR5 on CD4+ T cells correlated with advancing disease. In addition, a tendency for greater activation of CXCR4+CD4+ T cells in patients with advanced disease was observed. Patients who harboured syncytium-inducing viruses, however, could not be distinguished from those who harboured nonsyncytium-inducing viruses based on the level of CD4+ T-cell activation or chemokine receptor expression.
KW  - chemokines
KW  - cytokines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphocyte transformation
KW  - monocytes
KW  - receptors
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013724&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IFN-γ, IL-12, and TNF-α are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12.
AU  - Hoffmann, K. F.
AU  - Caspar, P.
AU  - Cheever, A. W.
AU  - Wynn, T. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 161
IS  - 8
SP  - 4201
EP  - 4210
SN  - 0022-1767
AD  - Hoffmann, K. F.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990803548.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9008-11-1, 308079-78-9.  Subject Subsets: Helminthology
N2  - This study of the immunopathology of schistosomiasis showed that mice sensitized with Schistosoma mansoni egg antigens and IL (interleukin)-12, but depleted of IFN (interferon)-γ, IL-12, or TNF (tumour necrosis factor)-α at the time of egg laying, developed granulomas that were similar to the non-IL-12-treated control group. This contrasts with previous findings that similarly sensitized mice not depleted of these cytokines showed marked decreases in pathology compared with controls. Although all 3 anti-cytokine-treated groups exhibited a dominant type 1 response in lymph node cells restimulated ex vivo, the expression of type 2 cytokine mRNA was markedly restored at the site of granuloma formation, which suggests that all 3 cytokines are required to maintain the suppressed type 2 pattern. Moreover, egg/IL-12-sensitized mice depleted of IFN-γ or IL-12 displayed a partial reduction in IFN-γ production, suggesting that multiple type 1 cytokines were required to maintain polarized type 1 responses to chronic type 2-inducing stimuli. Together, these data reveal key roles for IFN-γ, IL-12, and TNF-α in the prevention of immunopathology following immunization with egg antigen and IL-12.
KW  - animal diseases
KW  - antigens
KW  - cytokines
KW  - experimental infection
KW  - fibrosis
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - hepatic fibrosis
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - immunopathology
KW  - interferon
KW  - interleukin 12
KW  - laboratory animals
KW  - liver
KW  - lymph nodes
KW  - parasites
KW  - pathology
KW  - schistosomiasis
KW  - tumour necrosis factor
KW  - vaccine development
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - antigenicity
KW  - bilharzia
KW  - bilharziasis
KW  - cachectin
KW  - cachexin
KW  - experimental transmission
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803548&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
AU  - Wang JiMing
AU  - Ueda, H.
AU  - Howard, O. M. Z.
AU  - Grimm, M. C.
AU  - Chertov, O.
AU  - Gong XiaoQi
AU  - Gong WangHua
AU  - Resau, J. H.
AU  - Broder, C. C.
AU  - Evans, G.
AU  - Arthur, L. O.
AU  - Ruscetti, F. W.
AU  - Oppenheim, J. J.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1998///
VL  - 161
IS  - 8
SP  - 4309
EP  - 4317
SN  - 0022-1767
AD  - Wang JiMing: Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Rm 31-19, Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19982014285.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref.
N2  - This study shows that preincubation with gp120 from various strains of HIV-1 can suppress monocyte responses to a variety of chemokines as well as the bacterial peptide FMLP in association with CD4 signal-dependent down-regulation of chemokine receptors.
KW  - CD4 antigens
KW  - chemokines
KW  - cytokines
KW  - envelope protein gp120
KW  - human diseases
KW  - immune response
KW  - immunopathology
KW  - inflammation
KW  - monocytes
KW  - pathogenesis
KW  - receptors
KW  - Human immunodeficiency virus 1
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CD4
KW  - gp120
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014285&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recombinant cDNA clones for immunodiagnosis of strongyloidiasis.
AU  - Ramachandran, S.
AU  - Thompson, R. W.
AU  - Gam, A. A.
AU  - Neva, F. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 1
SP  - 196
EP  - 203
SN  - 0022-1899
AD  - Ramachandran, S.: Laboratory of Parasitic Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980804381.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 37341-29-0, 308067-58-5.  Subject Subsets: Helminthology
N2  - In order to make diagnosis of Strongyloides easier and more reliable, several recombinant clones from a cDNA library prepared from the infective stage of S. stercoralis, and screened with serum from strongyloidiasis patients, were characterized by sequencing the genes and expressing the proteins in Escherichia coli. Sequence analysis showed these antigens to be rich in proline and charged amino acids. Database searches revealed sequences which were similar but none which were homologous, suggesting that the antigens are unique. The results of ELISA testing indicated that recombinant proteins 5a and 12a were equally as reactive as the larval somatic antigen, if not more so. No cross-reactivity with recombinant antigen 5a was found using sera from patients with filarial or intestinal nematode infections, even though larval somatic antigen did cross-react with some of these. There was only one case of cross-reactivity with antigen 12a. Recombinant antigens 5a and 12a both detected parasite-specific IgE and IgG4 antibodies in Strongyloides-infected patients. It is concluded that these recombinant antigens should be useful in diagnostic and epidemiological studies of strongyloidiasis.
KW  - antibodies
KW  - antigens
KW  - diagnosis
KW  - DNA libraries
KW  - ELISA
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - IgG
KW  - immunodiagnosis
KW  - nucleotide sequences
KW  - parasites
KW  - recombinant antigens
KW  - recombinant DNA
KW  - recombinant proteins
KW  - strongyloidiasis
KW  - man
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Strongyloides
KW  - Strongyloididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - antigenicity
KW  - DNA sequences
KW  - enzyme linked immunosorbent assay
KW  - immunogens
KW  - nematodes
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Secernentea
KW  - serological diagnosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Investigational vaccine for Escherichia coli O157: phase 1 study of O157 O-specific polysaccharide-Pseudomonas aeruginosa recombinant exoprotein A conjugates in adults.
AU  - Konadu, E. Y.
AU  - Parke, J. C., Jr.
AU  - Tran, H. T.
AU  - Bryla, D. A.
AU  - Robbins, J. B.
AU  - Szu, S. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 2
SP  - 383
EP  - 387
SN  - 0022-1899
AD  - Konadu, E. Y.: National Institutes of Health, Bldg. 6, Room 424, Bethesda, MD 20892-2720, USA.
N1  - Accession Number: 19982008886.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 308067-58-5.  Subject Subsets: Public Health
N2  - In a phase 1 clinical study, 3 investigational E. coli O157 vaccines were studied in 87 healthy adults from North Carolina, USA [date not given]. The vaccines were prepared by covalently binding E. coli O157 O-specific polysaccharide with P. aeruginosa recombinant exoprotein A. No significant adverse reactions were reported. Most volunteers (81%) responded with a &gt;4-fold increase in IgG lipopolysaccharide (LPS) antibodies 1 week after vaccination; all volunteers responded with a &gt;4-fold rise at 4 weeks and this level was sustained for 26 weeks after injection. All 3 vaccines elicited high titres of serum bactericidal activity that roughly correlated with the serum IgG and IgM LPS antibody levels. A phase 2 study in young children is planned.
KW  - adults
KW  - antibodies
KW  - bacterial diseases
KW  - clinical trials
KW  - conjugate vaccines
KW  - efficacy
KW  - human diseases
KW  - IgG
KW  - IgM
KW  - immune response
KW  - immunization
KW  - lipopolysaccharides
KW  - vaccination
KW  - vaccines
KW  - North Carolina
KW  - USA
KW  - Escherichia coli
KW  - man
KW  - Pseudomonas aeruginosa
KW  - Escherichia
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pseudomonas
KW  - Pseudomonadaceae
KW  - Pseudomonadales
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - South Atlantic States of USA
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - E. coli
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - United States of America
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008886&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infection.
AU  - Lin, F. Y. C.
AU  - Clemens, J. D.
AU  - Azimi, P. H.
AU  - Regan, J. A.
AU  - Weisman, L. E.
AU  - Philips, J. B., III
AU  - Rhoads, G. G.
AU  - Clark, P.
AU  - Brenner, R. A.
AU  - Ferrieri, P.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 3
SP  - 790
EP  - 792
SN  - 0022-1899
AD  - Lin, F. Y. C.: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19982007465.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Public Health
N2  - The distribution of serotypes of group B streptococci (GBS) isolated from 67 infants with early-onset sepsis are described. Case-infants were assembled from 13 hospitals across the USA from 15 July 1995 to 5 February 1997 through prospective active surveillance. The distribution of GBS serotypes was Ia, 40%; Ib, 9%; II, 6%; III, 27%; V, 15%; and nontypeable, 3%. Type V occurred more frequently in the northeast region (New York and New Jersey) than in other regions (29% vs. 9%, P=0.06). Conversely, type III occurred significantly less frequently in the northeast region than other regions (10% vs. 35%, P=0.04). GBS types Ia, III, and V accounted for 82% of the isolates. It is concluded that this report supports previous observations about the emergence of GBS type V, but it is suggested that conclusions about serotype distributions based on one geographical location or on a small number of patients may not be generally applicable. Continued monitoring seems necessary for the design of a GBS vaccine.
KW  - bacterial diseases
KW  - epidemiology
KW  - group B streptococci
KW  - human diseases
KW  - neonates
KW  - polysaccharides
KW  - serotypes
KW  - USA
KW  - man
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - complex carbohydrates
KW  - newborn infants
KW  - United States of America
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007465&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Splenic cytokine responses in Indian kala-azar before and after treatment.
AU  - Kenney, R. T.
AU  - Sacks, D. L.
AU  - Gam, A. A.
AU  - Murray, H. W.
AU  - Shyam Sundar
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 3
SP  - 815
EP  - 819
SN  - 0022-1899
AD  - Kenney, R. T.: Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19980806492.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 1397-89-3, 12550-17-3, 9008-11-1, 130068-27-8, 207137-56-2.  Subject Subsets: Protozoology; Tropical Diseases
N2  - Cytokine messenger RNA (mRNA) levels were measured in serial splenic aspirates from 27 patients with visceral leishmaniasis (Leishmania donovani) during monotherapy with interferon (IFN)-γ (9 patients), sodium antimony gluconate (SAG; 8 patients), or amphotericin B lipid complex (ABLC; 10 patients) in Varanasi, India. At baseline, mRNA for IFN-γ was detected in 18 (86%) of 21 patients, and mRNA for interleukin (IL)-10 and IL-4 was detected in 21 (100%) and 10 (48%) of 21 patients, respectively. With IFN-γ treatment alone, levels of IFN-γ mRNA decreased by day 10 and then returned to baseline levels; IL-10 mRNA levels were high throughout treatment. In the SAG and ABLC groups, levels of IFN-γ and IL-10 mRNA decreased significantly. It is concluded that polarized Th2 cell type responses do not appear to develop in Indian kala-azar; instead, there is an initial mixed Th1-Th2 cell response. With successful treatment and resolution of infection, both components of the immune response appear to involute.
KW  - amphotericin B
KW  - antimony sodium gluconate
KW  - antiprotozoal agents
KW  - cytokines
KW  - drug therapy
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - interleukin 10
KW  - interleukin 4
KW  - kala azar
KW  - messenger RNA
KW  - parasites
KW  - spleen
KW  - visceral leishmaniasis
KW  - India
KW  - Leishmania donovani
KW  - man
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - chemotherapy
KW  - immunity reactions
KW  - immunological reactions
KW  - mRNA
KW  - sodium antimony gluconate
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806492&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.
AU  - Maeda, Y.
AU  - Venzon, D. J.
AU  - Mitsuya, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 5
SP  - 1207
EP  - 1213
SN  - 0022-1899
AD  - Maeda, Y.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg. 10, Rm 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982007284.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 69655-05-6, 30516-87-1. 
N2  - Investigations were done to determine whether the replication kinetics of HIV-1 were altered when the virus acquired a set of subsets of 5 mutations (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleosides. In the absence of drugs, the replication rate of all infectious clones generated was comparable to that of wild type HIV-1. However, in the presence of zidovudine or didanosine, the comparative order for replication was HIV-162/75/77/116/151&gt; HIV-177/116/151&gt; HIV-175/77/116/151~ HIV-1151, whereas that for drug resistance was HIV-175/77/116/151&gt; HIV-162/75/77/116/151≥ HIV-177/116/151&gt; HIV-1151. The virological features of these infectious mutants suggest that HIV-1 develops drug resistance through one or more mutations, which, however, sacrifice replicative capability; then it finally acquires optimal replication competence by additional mutations when the multi-dideoxynucleoside-resistant mutant emerges.
KW  - analogues
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - clones
KW  - didanosine
KW  - dideoxynucleosides
KW  - disease course
KW  - drug resistance
KW  - drugs
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - infections
KW  - kinetics
KW  - leukocyte count
KW  - mutants
KW  - mutations
KW  - nucleoside analogues
KW  - nucleosides
KW  - opportunistic infections
KW  - proteinase inhibitors
KW  - proteinases
KW  - regimens
KW  - relationships
KW  - replication
KW  - susceptibility
KW  - treatment
KW  - zidovudine
KW  - Illinois
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - Retroviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - East North Central States of USA
KW  - analogs
KW  - AZT
KW  - CD4+ cells
KW  - cell count
KW  - dideoxyinosine
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - medicines
KW  - nucleoside analogs
KW  - pharmaceuticals
KW  - protease inhibitors
KW  - proteases
KW  - T4 lymphocytes
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - The in vitro induction of human immunodeficiency virus (HIV) replication in purified protein derivative-positive HIV-infected persons by recall antigen response to Mycobacterium tuberculosis is the result of a balance of the effects of endogenous interleukin-2 and proinflammatory and antiinflammatory cytokines.
AU  - Goletti, D.
AU  - Weissman, D.
AU  - Jackson, R. W.
AU  - Collins, F.
AU  - Kinter, A.
AU  - Fauci, A. S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 5
SP  - 1332
EP  - 1228
SN  - 0022-1899
AD  - Goletti, D.: National Institute of Allergy and Infectious Diseases, NIH, BLDG. 31, RM 7A03, Bethesda, MD 20892-2520, USA.
N1  - Accession Number: 19982007286.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 308079-78-9, 102524-44-7, 85898-30-2. 
N2  - Coinfection with Mycobacterium tuberculosis and HIV is a serious problem, particularly in developing countries. Recently, M. tuberculosis and purified protein derivative (PPD) were demonstrated to induce HIV replication in CD8+ T-cell-depleted peripheral blood mononuclear cells from HIV-positive, PPD-positive persons but not in cells from PPD-negative persons. The role of endogenous and exogenous cytokines in modulating M. tuberculosis-induced HIV replication was evaluated. M. tuberculosis-induced HIV replication decreased following simultaneous inhibition of endogenous interleukin (IL)-2, IL-1β, and tumour necrosis factor-α by the addition of soluble receptors and receptor antagonists or following exogenous IL-10 and transforming growth factor (TGF)-β. In contrast, neutralization of endogenous IL-10 and TGF-β augmented M. tuberculosis-induced HIV replication by increasing cellular activation. Thus, the balance between IL-2 and proinflammatory and antiinflammatory cytokines plays a major role in M. tuberculosis-induced replication of HIV.
KW  - antigens
KW  - CD8+ lymphocytes
KW  - cytokines
KW  - growth factors
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - in vitro
KW  - inhibition
KW  - interleukin 2
KW  - mixed infections
KW  - neutralization
KW  - pathogenesis
KW  - replication
KW  - tuberculin
KW  - tumour necrosis factor
KW  - man
KW  - Mycobacterium tuberculosis
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - cachectin
KW  - cachexin
KW  - CD8+ cells
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - multiple infections
KW  - purified protein derivative
KW  - T8 lymphocytes
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007286&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy.
AU  - Kavlick, M. F.
AU  - Wyvill, K.
AU  - Yarchoan, R.
AU  - Mitsuya, H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 177
IS  - 6
SP  - 1506
EP  - 1513
SN  - 0022-1899
AD  - Kavlick, M. F.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982008411.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 9068-38-6, 63231-63-0. 
N2  - A set of 5 reverse transcriptase mutations, which include Q151M, is known to confer multidideoxynucleoside resistance (MDR) in HIV-1. MDR mutations were found in 6 (17%) HIV-1 isolates from 36 patients, most of whom were receiving long-term combination therapy. Q151M was among the first of the substitutions to appear. Additional substitutions were observed, although none was common among all 6 patients. Certain zidovudine-related mutations were not observed together with MDR mutations, indicating possible enzymatic constraint. During chemotherapy, the HIV-1 RNA levels in the 6 patients initially decreased and then rose. Initially, CD4+ cell counts also responded favourably but were near or below baseline beyond 40 months of therapy. Such loss of clinical benefits appeared to coincide with the appearance of the MDR mutations. A common background genotype was not observed among HIV-1 isolates with or without MDR.
KW  - analogues
KW  - antiviral agents
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - clinical aspects
KW  - combination therapy
KW  - disease course
KW  - drug resistance
KW  - drug therapy
KW  - genotypes
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - leukocyte count
KW  - mutations
KW  - nucleoside analogues
KW  - nucleosides
KW  - reverse transcriptase
KW  - RNA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analogs
KW  - CD4
KW  - CD4+ cells
KW  - cell count
KW  - chemotherapy
KW  - clinical picture
KW  - combined modality therapy
KW  - disease progression
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - multimodal treatment
KW  - nucleoside analogs
KW  - ribonucleic acid
KW  - T4 lymphocytes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data.
AU  - Ioannidis, J. P. A.
AU  - Collier, A. c.
AU  - Cooper, D. A.
AU  - Corey, L.
AU  - Fiddian, A. P.
AU  - Gazzard, B. G.
AU  - Griffiths, P. D.
AU  - Contopoulos-Ioannidis, D. G.
AU  - Lau, J.
AU  - Pavia, A. T.
AU  - Saag, M. S.
AU  - Spruance, S. L.
AU  - Youle, M. S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 2
SP  - 349
EP  - 359
SN  - 0022-1899
AD  - Ioannidis, J. P. A.: HIV Research Branch, National Institute of Allergy and Infectious Diseases, Solar Bldg., Rm 2C31, 6003 Executive Blvd., Bethesda, MD 20892, USA.
N1  - Accession Number: 19982011008.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 59277-89-3. 
N2  - A meta-analysis of 8 randomized trials (1792 patients, 2947 patient-years of follow-up) showed that acyclovir (≥3200 mg/day) offered a significant survival benefit (P=0.006 by log-rank test) in HIV infection. The treatment effect did not vary significantly in patient subgroups of different CD4+ cell counts, haemoglobin levels, age, race, and sex, and with or without AIDS diagnosis. Acyclovir treatment (hazard ratio, 0.78; 95% CI 0.65-0.93), higher CD4+ cell count (P &lt;0.001), higher haemoglobin level (P &lt;0.001), and younger age (P&lt;0.001) reduced the hazard of mortality. Acyclovir decreased herpes simplex virus infections (odds ratio [OR], 0.28; 95% CI, 0.21-0.37) and varicella-zoster virus infections (OR, 0.29; 95% CI, 0.1-0.63) but not cytomegalovirus disease or mortality from lymphoma or Kaposi's sarcoma. A survival advantage was seen specifically in studies with high incidence of clinical herpesvirus infections (≥25% per year). Given the wide confidence intervals, the small effect in low-risk patients, and recent changes in HIV therapeutics, the results should be interpreted cautiously, but the meta-analysis supports the importance of pathogenetic interactions between herpesviruses and HIV.
KW  - aciclovir
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - diagnosis
KW  - drug therapy
KW  - herpes simplex
KW  - herpes simplex viruses
KW  - HIV infections
KW  - human diseases
KW  - human herpesviruses
KW  - human immunodeficiency viruses
KW  - interactions
KW  - Kaposi's sarcoma
KW  - leukocyte count
KW  - lymphoma
KW  - mortality
KW  - statistical analysis
KW  - survival
KW  - therapy
KW  - treatment
KW  - viral diseases
KW  - Cytomegalovirus
KW  - Herpesviridae
KW  - Human herpesvirus 3
KW  - man
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Varicellovirus
KW  - Alphaherpesvirinae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - acyclovir
KW  - AIDS
KW  - CD4+ cells
KW  - cell count
KW  - chemotherapy
KW  - death rate
KW  - herpes simplex virus
KW  - Human herpesvirus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - statistical methods
KW  - T4 lymphocytes
KW  - therapeutics
KW  - Varicella-Zoster virus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The influence of pregnancy on human immunodeficiency virus type 1 infection: antepartum and postpartum changes in human immunodeficiency virus type 1 viral load.
AU  - Burns, D. N.
AU  - Landesman, S.
AU  - Minkoff, H.
AU  - Wright, D. J.
AU  - Waters, D.
AU  - Mitchell, R. M.
AU  - Rubinstein, A.
AU  - Willoughby, A.
AU  - Goedert, J. J.
JO  - American Journal of Obstetrics and Gynecology
JF  - American Journal of Obstetrics and Gynecology
Y1  - 1998///
VL  - 178
IS  - 2
SP  - 355
EP  - 359
AD  - Burns, D. N.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 4B11, Rockville, MD 20892-7510, USA.
N1  - Accession Number: 19982005660.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 63231-63-0. 
N2  - The objective of this study was to examine the influence of pregnancy on HIV-1 viral load by measuring HIV-1 RNA levels during pregnancy and post partum in 160 women. Overall, HIV-1 RNA levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% CI 0.03 to 0.15 logs per year; P = 0.005). However, the mean slope during pregnancy was not significantly different from zero (P = 0.65). Thus pregnancy had little immediate effect on HIV-1 load in most HIV-1 seropositive women.
KW  - disease course
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pregnancy
KW  - RNA
KW  - viral load
KW  - women
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - disease progression
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Women (UU500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005660&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hemoglobin differentially induces binding of Candida, Trichosporon, and Saccharomyces species to fibronectin.
AU  - Rodrigues, R. G.
AU  - Yan, S.
AU  - Walsh, T. J.
AU  - Roberts, D. D.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 2
SP  - 497
EP  - 502
SN  - 0022-1899
AD  - Rodrigues, R. G.: Laboratory of Pathology and Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19981202546.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Binding of fibronectin (FN) in solution to Candida, Trichosporon and Saccharomyces spp. was increased 20- to 110-fold by growth in medium containing haemoglobin, but specific adhesion to immobilized FN was increased only in C. albicans, C. tropicalis, C. krusei and C. glabrata [Torulopsis glabrata]. Haemoglobin induced both specific and non-specific binding of soluble FN. Non-specific binding accounted for all of the enhancement in Trichosporon beigelii and S. cerevisiae, but the Candida spp. possessed a saturable, high-affinity binding site for FN that was induced by haemoglobin. Induction of displaceable soluble FN binding correlated with the ability of haemoglobin to regulate adhesion to immobilized FN, since haemoglobin does not induce adhesion of S. cerevisiae or T. beigelii to immobilized FN. It is suggested that regulation by haemoglobin of FN binding to Candida spp. may therefore be an important factor in the pathogenesis of these yeast infections.
KW  - adhesion
KW  - candidosis
KW  - haemoglobin
KW  - pathogenesis
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida tropicalis
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Trichosporon beigelii
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Torulopsis
KW  - Pezizomycotina
KW  - Trichosporon
KW  - Trichosporonaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Candida krusei
KW  - candidiasis
KW  - fibronectin
KW  - fungus
KW  - hemoglobin
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis.
AU  - Roilides, E.
AU  - Sein, T.
AU  - Schaufele, R.
AU  - Chanock, S. J.
AU  - Walsh, T. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 2
SP  - 589
EP  - 592
SN  - 0022-1899
AD  - Roilides, E.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981202547.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Serum levels of 2 immunosuppressive cytokines, markers of the Th2 pathway, interleukin (IL)-4 and IL-10, were measured by ELISA in 10 cancer patients from the USA with hepatosplenic candidosis (HSC) (22 samples) and compared with 19 healthy blood donors, 13 patients with cancer but no infection (23 samples), and 11 patients with cancer and various bacterial infections (17 samples). IL-4 was undetectable in all controls and patients. By contrast, levels of IL-10 were increased in HSC patients compared with levels in healthy donors and cancer patients without infection (P&lt;0.001) or with bacterial infections (P&lt;0.01). It is concluded that IL-10 but not IL-4 is increased in patients with hepatosplenic Candida infections and it is suggested that IL-10 plays a role in the pathogenesis of this infection.
KW  - candidosis
KW  - cytokines
KW  - human diseases
KW  - immune response
KW  - immunocompromised hosts
KW  - immunopathology
KW  - infections
KW  - interleukins
KW  - liver
KW  - neoplasms
KW  - opportunistic infections
KW  - predisposition
KW  - spleen
KW  - USA
KW  - Candida
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - candidiasis
KW  - fungus
KW  - Hyphomycetes
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae.
AU  - Pikis, A.
AU  - Donkersloot, J. A.
AU  - Rodriguez, W. J.
AU  - Keith, J. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 3
SP  - 700
EP  - 706
SN  - 0022-1899
AD  - Pikis, A.: Vaccine and Therapeutic Development Section, Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982014070.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9002-03-3, 738-70-5.  Subject Subsets: Public Health
N2  - The molecular mechanism of trimethoprim resistance was investigated in 5 pneumococcal strains isolated in Washington, DC, USA from patients with invasive infections. Cloning and sequencing of the trimethoprim resistance determinant from these pneumococci indicated that an altered chromosome-encoded dihydrofolate reductase (DHFR) was responsible for the observed resistance. Comparison of DHFR sequences from pneumococcal strains with various susceptibilities to trimethoprim, together with site-directed mutagenesis, revealed that substitution of isoleucine-100 with a leucine residue resulted in trimethoprim resistance. Hydrogen bonding between the carbonyl oxygen of isoleucine-100 and the 4-amino group of trimethoprim is proposed to play a critical role in the inhibition of DHFR by trimethoprim. This enzyme-substrate model should facilitate the design of new antibacterial agents with improved activity against S. pneumoniae.
KW  - dihydrofolate reductase
KW  - drug resistance
KW  - human diseases
KW  - mutations
KW  - strains
KW  - trimethoprim
KW  - District of Columbia
KW  - USA
KW  - man
KW  - Streptococcus pneumoniae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Streptococcus
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - tetrahydrofolate dehydrogenase
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014070&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Abnormal regulation of interferon-γ, interleukin-12, and tumor necrosis factor-α in human interferon-γ receptor 1 deficiency.
AU  - Holland, S. M.
AU  - Dorman, S. E.
AU  - Kwon, A.
AU  - Pitha-Rowe, I. F.
AU  - Frucht, D. M.
AU  - Gerstberger, S. M.
AU  - Noel, G. J.
AU  - Vesterhus, P.
AU  - Brown, M. R.
AU  - Fleisher, T. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 4
SP  - 1095
EP  - 1104
SN  - 0022-1899
AD  - Holland, S. M.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992000702.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 9008-11-1, 308079-78-9. 
N2  - The immunological sequelae of interferon-γ receptor ligand-binding chain (IFN-γR1) deficiency were characterized in 2 unrelated patients from the Indian subcontinent with severe disseminated nontuberculous mycobacterial infections and novel homozygous recessive IFN-γR1 mutations. In vitro, these patients' peripheral blood mononuclear cells produced 10% of normal IFN-γ and interleukin-12 (IL-12) in response to phytohaemagglutinin (PHA) but normal amounts of IFN-γ in response to PHA plus IL-12. Tumour necrosis factor (TNF)-α production was normal in response to endotoxin and to PHA but was not augmented by the addition of IFN-γ. An abnormal phenotype was not found in heterozygous patient relatives. It is concluded that the IFN-γ receptor plays a critical role in the regulation of IFN-γ, IL-12 and TNF-α.
KW  - bacterial diseases
KW  - case reports
KW  - cell mediated immunity
KW  - children
KW  - cytokines
KW  - genetic disorders
KW  - human diseases
KW  - immune response
KW  - immunological deficiency
KW  - interferon
KW  - interleukin 12
KW  - interleukins
KW  - mutations
KW  - receptors
KW  - tumour necrosis factor
KW  - Pakistan
KW  - man
KW  - Mycobacterium
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - cachectin
KW  - cachexin
KW  - cellular immunity
KW  - genetic defects
KW  - hereditary defects
KW  - immune deficiency
KW  - immunity reactions
KW  - immunodeficiency
KW  - immunological reactions
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10.
AU  - Cooper, P. J.
AU  - Espinel, I.
AU  - Paredes, W.
AU  - Guderian, R. H.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 4
SP  - 1133
EP  - 1138
SN  - 0022-1899
AD  - Cooper, P. J.: Laboratory of Parasitic Diseases, NIAID, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990802533.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 9008-11-1, 130068-27-8.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Onchocerca volvulus infection has been associated with impaired cellular responses to parasite antigens, an impairment that may also extend to nonparasite antigens. To investigate the mechanism of this impaired immune response, the effect of concurrent O. volvulus infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied. The proliferative, cytokine, and antibody response to TT of O. volvulus-infected subjects (n = 19) and comparable non-infected controls (n = 20) from Esmeraldas Province, Ecuador, were studied before and 6 months after vaccination with TT. Following vaccination, antibody levels, proliferative responses, and levels of interferon-γ were significantly greater in non-infected subjects (P&lt;0.05, P&lt;0.001 and P&lt;0.05, respectively); however, infected subjects produced interleukin-10, but non-infected controls did not (P&lt;0.001). It is suggested that concurrent infection with O. volvulus can diminish the immune response to an unrelated antigen (TT) by a mechanism that is likely to involve interleukin-10.
KW  - antibodies
KW  - antigens
KW  - cytokines
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - immunization
KW  - interferon
KW  - interleukin 10
KW  - lymphocyte transformation
KW  - onchocerciasis
KW  - parasites
KW  - tetanus toxoid
KW  - toxoids
KW  - Ecuador
KW  - Clostridium tetani
KW  - man
KW  - Onchocerca volvulus
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - antigenicity
KW  - bacterium
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802533&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature-dependent blockage of the flea.
AU  - Hinnebusch, B. J.
AU  - Fischer, E. R.
AU  - Schwan, T. G.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 5
SP  - 1406
EP  - 1415
SN  - 0022-1899
AD  - Hinnebusch, B. J.: National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19990500960.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Registry Number: 9039-53-6.  Subject Subsets: Medical & Veterinary Entomology
N2  - Yersinia pestis has a plasminogen activator (pla) gene on the 9.5-kb plasmid pPla that is hypothesized to play a role in producing the foregut blockage in the flea vector that precedes transmission. In this study, however, Y. pestis that lacked pPla, the 70kb virulence plasmid, or both plasmids, proved able to block Xenopsylla cheopis fleas normally. Blockage rates decreased with increasing environmental temperature for fleas infected with either wild type or pPla-Y. pestis. Thus, procoagulant ability of the Y. pestis pla gene product does not mediate blockage, nor does its ability to induce fibrinolysis at &gt;28°C account for failure to block at elevated temperatures. A Y. pestis strain that lacked all or part of the third plasmid of 110 kb, however, failed to colonize the flea midgut normally, indicating that one or more genes on the large plasmid may be required for vector-borne transmission.
KW  - disease transmission
KW  - disease vectors
KW  - ectoparasites
KW  - genes
KW  - plasmids
KW  - plasminogen activator
KW  - temperature
KW  - virulence
KW  - Siphonaptera
KW  - Xenopsylla cheopis
KW  - Yersinia pestis
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Xenopsylla
KW  - Pulicidae
KW  - Siphonaptera
KW  - Yersinia (Bacteria)
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - Oriental rat flea
KW  - urokinase
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500960&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Combination therapy with famciclovir and interferon-α for the treatment of chronic hepatitis B.
AU  - Marques, A. R.
AU  - Lau, D. T. Y.
AU  - McKenzie, R.
AU  - Straus, S. E.
AU  - Hoofnagle, J. H.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 5
SP  - 1483
EP  - 1487
SN  - 0022-1899
AD  - Marques, A. R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19992001650.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 9008-11-1, 104227-87-4.  Subject Subsets: Public Health
N2  - Five adults with chronic HBV infection in whom previous interferon-α (IFN-α) therapy had failed were treated in a pilot study [in the USA] of overlapping IFN-α and famciclovir therapy totalling 20 weeks. HBV DNA levels decreased by 0.9 log units during the initial 4-week period of famciclovir alone, followed by a further decrease of 1.8 logs during the middle 12-week period of combination therapy. HBV DNA rose by 0.9 log during the final 4-week period of IFN-α alone. Two patients cleared HBV DNA, and their liver disease improved by clinical and histological criteria. The combination of famciclovir and IFN-α appeared to be at least additive in suppressing HBV DNA. It is concluded that efficacy trials of combination therapy with famciclovir and IFN-α are warranted.
KW  - clinical aspects
KW  - combination therapy
KW  - drug combinations
KW  - drug therapy
KW  - famciclovir
KW  - hepatitis B
KW  - human diseases
KW  - interferon
KW  - Maryland
KW  - USA
KW  - hepatitis B virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - clinical picture
KW  - combined modality therapy
KW  - multimodal treatment
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001650&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interferon-γ and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis.
AU  - Neva, F. A.
AU  - Oliveira Filho, J.
AU  - Gam, A. A.
AU  - Thompson, R.
AU  - Freitas, V.
AU  - Melo, A.
AU  - Carvalho, E. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1998///
VL  - 178
IS  - 6
SP  - 1856
EP  - 1859
SN  - 0022-1899
AD  - Neva, F. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990802436.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 37341-29-0, 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - A study was carried out in Brazil to investigate the interaction between infection with human T lymphotropic virus type 1 (HTLV-1) and Strongyloides stercoralis in individuals infected with one or both agents. The cytokine responses of peripheral blood mononuclear cells (PBMC) to mitogens and Strongyloides antigen were studied. PBMC of subjects infected with HTLV-1 spontaneously produced interferon (IFN)-γ with levels that correlated inversely with serum IgE levels. HTLV-1-infected subjects also had poor interleukin (IL)-4 responses to mitogenic stimulation, unlike persons without HTLV-1 infection. It is postulated that the IFN-γ produced by activated T cells in some HTLV-1-infected persons acts to down-regulate IL-4 with consequent reduction of serum IgE levels. It is suggested that the impaired IgE responses and other effects of IL-4 down-regulation may be contributing factors to more severe disease and impaired response to treatment of strongyloidiasis in some HTLV-1-infected persons.
KW  - antigens
KW  - cytokines
KW  - helminths
KW  - HTLV infections
KW  - human diseases
KW  - IgE
KW  - immune response
KW  - immunocompromised hosts
KW  - interactions
KW  - interferon
KW  - interleukin 4
KW  - mixed infections
KW  - opportunistic infections
KW  - parasites
KW  - strongyloidiasis
KW  - T lymphocytes
KW  - Brazil
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Strongyloides
KW  - Strongyloididae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - antigenicity
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - multiple infections
KW  - nematodes
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Secernentea
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802436&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence.
AU  - Tsai HuieFung
AU  - Chang, Y. C.
AU  - Washburn, R. G.
AU  - Wheeler, M. H.
AU  - Kwon-Chung, K. J.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1998///
VL  - 180
IS  - 12
SP  - 3031
EP  - 3038
SN  - 0021-9193
AD  - Tsai HuieFung: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201965.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - An A. fumigatus gene, alb1, which is required for conidial pigmentation was identified. The alb1 gene encodes a putative polyketide synthase and disruption of alb1 resulted in an albino conidial phenotype. Expression of alb1 is developmentally regulated and the 7-kb transcript is detected only during the conidiation stage. The alb1 mutation was found to block 1,3,6,8-tetrahydroxynaphthalene production, indicating that alb1 is involved in dihydroxynaphthalene-melanin biosynthesis. Scanning electron microscopy studies showed that the alb1 disruptant exhibited a smooth conidial surface, whereas complementation of the alb1 deletion restored the echinulate wild-type surface. Disruption of alb1 resulted in a significant increase in C3 binding on conidial surfaces and the conidia of the alb1 disruptant were ingested by human neutrophils at a higher rate than were those of the wild type. The alb1-complemented strain producing bluish-green conidia exhibited inefficient C3 binding and neutrophil-mediated phagocytosis quantitatively similar to those of the wild type. The alb1 disruptant had a statistically significant loss of virulence compared with the wild-type and alb1-complemented strains in a murine model. It is suggested that disruption of alb1 causes pleiotropic effects on conidial morphology and fungal virulence.
KW  - aspergillosis
KW  - experimental infections
KW  - genes
KW  - infections
KW  - morphology
KW  - pathogenicity
KW  - virulence
KW  - Aspergillus fumigatus
KW  - mice
KW  - Aspergillus
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201965&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transformation of the Lyme disease spirochete Borrelia burgdorferi with heterologous DNA.
AU  - Stevenson, B.
AU  - Bono, J. L.
AU  - Elias, A.
AU  - Tilly, K.
AU  - Rosa, P.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1998///
VL  - 180
IS  - 18
SP  - 4850
EP  - 4855
SN  - 0021-9193
AD  - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19990501774.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2  - A method was developed by which heterologous DNA (DNA without a naturally occurring B. burgdorferi homologue) can be introduced into and persistently maintained by B. burgdorferi. This technique uses integration of circular DNA into the bacterial genome via a single-crossover event. The ability to transform B. burgdorferi with heterologous DNA will now permit a wide range of experiments on the biology of these bacteria and their involvement in the many facets of Lyme disease.
KW  - biotechnology
KW  - genomes
KW  - molecular genetics
KW  - plasmids
KW  - transformation
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - biochemical genetics
KW  - cloning
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990501774&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signalling.
AU  - Jankovic, D.
AU  - Cheever, A. W.
AU  - Kullberg, M. C.
AU  - Wyn, T. A.
AU  - Yap, G.
AU  - Caspar, P.
AU  - Lewis, F. A.
AU  - Clynes, R.
AU  - Ravetch, J. V.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1998///
VL  - 187
IS  - 4
SP  - 619
EP  - 629
SN  - 0022-1007
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980803156.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Subject Subsets: Helminthology
N2  - The pathogenesis of schistosomiasis was studied in B cell deficient µMT mice infected with Schistosoma mansoni (Puerto Rican strain) by exposure of the tail to cercariae. The mice developed augmented tissue pathology and failed to undergo the spontaneous downmodulation in disease normally observed during late stages of infection. Unexpectedly, B cell deficiency did not significantly alter the T cell proliferative response or cause a shift in the Th1/Th2 balance. Since schistosome-infected Fc receptor-deficient (FcR γ chain knockout) mice displayed the same exacerbated egg pathology as that observed in infected µMT mice, it is suggested that the B cell-dependent regulatory mechanism revealed by these experiments requires receptor-mediated cell triggering. It is concluded that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells.
KW  - B lymphocytes
KW  - experimental infections
KW  - granuloma
KW  - helminths
KW  - immunopathology
KW  - laboratory animals
KW  - parasites
KW  - pathology
KW  - schistosomiasis
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - B cells
KW  - bilharzia
KW  - bilharziasis
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803156&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with Histoplasma capsulatum.
AU  - Ping Zhou
AU  - Seder, R. A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1998///
VL  - 187
IS  - 8
SP  - 1315
EP  - 1324
SN  - 0022-1007
AD  - Ping Zhou: Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19981201629.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The role of CD40 ligand (CD40L) in mediating protection against infection with H. capsulatum was investigated using CD40L-deficient (CD40L-/-) and CD40L+/+ mice. Animals were infected with H. capsulatum and assessed for various parameters. After a lethal challenge of H. capsulatum, CD40L-/- mice were not substantially different from CD40L+/+ mice in terms of mortality, fungal burden or production of interferon-γ (IFN-γ), interleukin 12 (IL-12), nitric oxide or tumour necrosis factor α. Moreover, CD40L-/- mice treated with anti-IFN-γ or anti-IL-12 at the time of infection had accelerated mortality, providing further evidence that IL-12 and IFN-γ are produced in vivo in the absence of CD40L. In addition, CD40L-/- mice infected with a sublethal dose of H. capsulatum survived infection, whereas all mice infected with the same dose and treated with anti-IFN-γ had accelerated mortality, demonstrating that IFN-γ but not CD40L was essential for primary immunity to H. capsulatum infection. Depletion of either CD4+ or CD8+ T cells resulted in accelerated mortality in CD40L-/- mice, suggesting a critical role for these cells in response to infection. Finally, CD40L-/- mice initially infected with a sublethal dose of H. capsulatum were protected from secondary infection with a lethal dose of H. capsulatum, demonstrating that CD40L is not required for the maintenance of memory immunity.
KW  - cytokines
KW  - experimental infections
KW  - histoplasmosis
KW  - immune response
KW  - immunity
KW  - infections
KW  - Histoplasma capsulatum
KW  - mice
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Histoplasma
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Ajellomyces capsulatus
KW  - fungus
KW  - immunity reactions
KW  - immunological reactions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201629&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adherence of erythrocytes during exflagellation of Plasmodium falciparum microgametes is dependent on erythrocyte surface sialic acid and glycophorins.
AU  - Templeton, T. J.
AU  - Keister, D. B.
AU  - Muratova, O.
AU  - Procter, J. L.
AU  - Kaslow, D. C.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1998///
VL  - 187
IS  - 10
SP  - 1599
EP  - 1609
SN  - 0022-1007
AD  - Templeton, T. J.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990804796.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref. Subject Subsets: Protozoology
N2  - Male Plasmodium gametocytes within a newly ingested infected blood meal in the mosquito midgut emerge from erythrocytes and extrude approximately 8 flagellar microgametes (exflagellation). In culture, and in blood removed from infected patients, emerging microgametes avidly adhere to neighbouring uninfected and infected erythrocytes, as well as to emerged female macrogametes. The proposition of a function underlying erythrocyte adherence is supported by the observation of species-specificity in adhesion: microgametes of P. falciparum can bind human but not chicken erythrocytes, whereas P. gallinaceum microgametes bind chicken but not human erythrocytes. A binding assay was developed in which normal, enzyme-treated, variant or null erythrocytes were identified by a cell surface fluorescent label and assayed for adherence to exflagellating microgametes. Neuraminidase, trypsin or ficin treatment of human erythrocytes eliminated the ability to adhere to P. falciparum microgametes, suggesting a role of sialic acid and one or more glycophorins in the binding to a putative gamete receptor. Using nulls lacking glycophorin A [En(a-)], glycophorin B (S-s-U-) or a combination of glycophorin A and B (Mk/Mk), it was shown that erythrocytes lacking glycophorin B retain the ability to bind but a lack of glycophorin A reduced adherence by exflagellating microgametes. It is proposed that either the sialic acid moiety of glycophorins, predominantly glycophorin A, or a more complex interaction involving the glycophorin peptide backbone, is the erythrocyte receptor for adhesion to microgametes.
KW  - assays
KW  - binding
KW  - cytoadherence
KW  - development
KW  - developmental stages
KW  - erythrocytes
KW  - gametes
KW  - host parasite relationships
KW  - parasites
KW  - receptors
KW  - reproduction
KW  - Plasmodium
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - blood red cells
KW  - cell adhesion
KW  - glycophorins
KW  - growth phase
KW  - microgametes
KW  - parasite host relationships
KW  - red blood cells
KW  - sialic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804796&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of HIV-1 replication in latently infected CD4+ cells using a combination of cytokines.
AU  - Chun, T. W.
AU  - Engel, D.
AU  - Mizell, S. B.
AU  - Ehler, L. A.
AU  - Fauci, A. S.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1998///
VL  - 188
IS  - 1
SP  - 83
EP  - 91
SN  - 0022-1007
AD  - Chun, T. W.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, Rm 6A32, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982010886.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 308079-78-9. 
N2  - Although it has been demonstrated that certain cytokines, particularly proinflammatory cytokines, can enhance ongoing viral replication in peripheral blood mononuclear cells (PBMCs) of HIV-1-infected individuals, it is unclear what role these cytokines play in the induction of HIV-1 replication in latently infected, resting CD4+ T cells. This study demonstrates that the in vitro combination of the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α together with the immunoregulatory cytokine IL-2 are potent inducers of viral replication in highly purified, latently infected, resting CD4+ T cells derived from HIV-infected individuals who are antiretroviral therapy-naive as well as those who are receiving highly active antiretroviral therapy (HAART). Viral replication induced by this combination of cytokines was completely suppressed in the presence of HAART in vitro. Given that an array of cytokines, including IL-6, TNF-α, and IL-2, are copiously expressed in the microenvironment of the lymphoid tissues, which harbour the latent viral reservoirs, induction of HIV by this combination of cytokines may in part explain the commonly observed reappearance of detectable plasma viraemia in HIV-infected individuals in whom HAART was discontinued. Moreover, since it is likely that these infected cells die upon activation of virus and that HAART prevents spread of virus to adjacent cells, the observation that this combination of cytokines can markedly induce viral replication in this reservoir may have important implications for the activation-mediated diminution of the latent reservoir of HIV in patients receiving HAART.
KW  - antiviral agents
KW  - blood plasma
KW  - CD4+ lymphocytes
KW  - combination therapy
KW  - cytokines
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - interleukins
KW  - pathogenesis
KW  - replication
KW  - T lymphocytes
KW  - tumour necrosis factor
KW  - viral replication
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cachectin
KW  - cachexin
KW  - CD4+ cells
KW  - chemotherapy
KW  - combined modality therapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - multimodal treatment
KW  - plasma (blood)
KW  - T cells
KW  - T4 lymphocytes
KW  - tumor necrosis factor
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010886&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity.
AU  - Stebut, E. von
AU  - Belkaid, Y.
AU  - Jakob, T.
AU  - Sacks, D. L.
AU  - Udey, M. C.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1998///
VL  - 188
IS  - 8
SP  - 1547
EP  - 1552
SN  - 0022-1007
AD  - Stebut, E. von: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. 12N238, 9000 Rockville Pike, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19990802537.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 9008-11-1.  Subject Subsets: Protozoology
N2  - Using Langerhans cell (LC)-like dendritic cells (DC) expanded from C57BL/6 fetal skin, interactions involving several developmental stages of Leishmania and DC were characterized. It was confirmed that L. major amastigotes, but not promastigotes, efficiently entered LC-like DCs. Parasite internalization was associated with activation manifested by upregulation of major histocompatibility complex (MHC) class I and II surface antigens, increased expression of costimulatory molecules (CD40, CD54, CD80 and CD86), and IL-12 p40 release within 18 h. L. major-induced IL-12 p70 release by DC required interferon-γ and prolonged (72 h) incubation. In contrast, infection of inflammatory macrophages with amastigotes or promastigotes did not lead to significant changes in surface antigen expression or cytokine production. The results suggest that skin macrophages and DC are infected sequentially in cutaneous leishmaniasis and that they play distinct roles in the inflammatory and immune response initiated by L. major. Macrophages capture organisms near the site of inoculation early in the course of infection after establishment of cellular immunity, and kill amastigotes but probably do not actively participate in T cell priming. In contrast, skin DC are induced to express increased amounts of MHC antigens and costimulatory molecules and to release cytokines (including IL-12 p70) by exposure to L. major amastigotes that ultimately accumulate in lesional tissue, and thus very likely initiate protective T helper cell type 1 immunity.
KW  - amastigotes
KW  - cytokines
KW  - immune response
KW  - immunity
KW  - interferon
KW  - interleukin 12
KW  - macrophages
KW  - major histocompatibility complex
KW  - parasites
KW  - promastigotes
KW  - skin
KW  - surface antigens
KW  - T lymphocytes
KW  - Leishmania major
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - dermis
KW  - histocompatibility complex
KW  - immunity reactions
KW  - immunological reactions
KW  - Langerhans cells
KW  - metacyclic forms
KW  - T cells
KW  - T helper cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802537&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis.
AU  - Belkaid, Y.
AU  - Kamhawi, S.
AU  - Modi, G.
AU  - Valenzuela, J.
AU  - Noben-Trauth, N.
AU  - Rowton, E.
AU  - Ribeiro, J.
AU  - Sacks, D. L.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1998///
VL  - 188
IS  - 10
SP  - 1941
EP  - 1953
SN  - 0022-1007
AD  - Belkaid, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990801600.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Registry Number: 207137-56-2.  Subject Subsets: Protozoology
N2  - A model of cutaneous leishmaniasis due to Leishmania major was developed that attempts to mimic the natural conditions of infection. 1000 metacyclic promastigotes were coinoculated with a salivary gland sonicate (SGS) obtained from Phlebotomus papatasi into the ear dermis of naive mice or of mice pre-exposed to SGS. The study revealed a dramatic exacerbating effect of SGS on lesion development in the dermal site and a complete abrogation of this effect in mice pre-exposed to salivary components. In both BALB/c and C57B1/6 (B/6) mice, the dermal lesions appeared earlier, were more destructive and contained greater numbers of parasites after infection in the presence of SGS. Furthermore, coinoculation of SGS converted B/6 mice into a nonhealing phenotype. No effect of SGS was seen in either interleukin (IL)-4-deficient or in SCID mice. Disease exacerbation in both BALB/c and B/6 mice was associated with an early (6 h) increase in the frequency of epidermal cells producing Th2 cytokines. SGS did not elicit Th2 cytokines in the epidermis of mice previously injected with SGS. These mice made antisaliva antibodies that were able to neutralize the ability of SGS to enhance infection and to elicit IL-4 and IL-5 responses in the epidermis. The results suggest that a history of exposure to vector saliva for individuals at risk of vector-borne infections might influence the outcome of exposure to transmitted parasites.
KW  - cutaneous leishmaniasis
KW  - cytokines
KW  - disease models
KW  - ears
KW  - epidermis
KW  - experimental infections
KW  - extracts
KW  - immune response
KW  - interactions
KW  - interleukin 4
KW  - interleukin 5
KW  - laboratory animals
KW  - parasites
KW  - pathogenesis
KW  - promastigotes
KW  - saliva
KW  - salivary glands
KW  - skin
KW  - skin diseases
KW  - skin lesions
KW  - T lymphocytes
KW  - vector-borne diseases
KW  - Leishmania major
KW  - mice
KW  - Phlebotomus papatasi
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Phlebotomus
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - dermatoses
KW  - dermis
KW  - immunity reactions
KW  - immunological reactions
KW  - salivary secretions
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801600&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification and cloning of the salivary nitrophorin from the hemipteran Cimex lectularius.
AU  - Valenzuela, J. G.
AU  - Ribeiro, J. M. C.
JO  - Journal of Experimental Biology
JF  - Journal of Experimental Biology
Y1  - 1998///
VL  - 201
IS  - 18
SP  - 2659
EP  - 2664
SN  - 0022-0949
AD  - Valenzuela, J. G.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980506636.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 87-89-8, 10102-43-9.  Subject Subsets: Medical & Veterinary Entomology
N2  - The salivary nitrophorin of C. lectularius was purified by DEAE chromatography and reverse-phase high-performance liquid chromatography. The purified nitrophorin had a molecular mass of 32.9 kDa. The DEAE-purified haemoprotein was able to bind nitric oxide (NO), and this binding shifted the absorption maximum from 388 nm to 438 nm. The ratio of haem to apoprotein was estimated to be of 1:1. A cDNA clone of 1079 base pairs was sequenced and was found to code for a protein with a molecular mass of 31.7 kDa. The clone sequence was in agreement with the internal peptide sequences obtained from the purified protein. Sequencing of the isolated clone indicates high similarity to several inositol phosphatases; however, no significant similarities emerged when the sequence of C. lectularius nitrophorin was compared with that of R. prolixus nitrophorin, the only other nitrophorin known in insect saliva. Since C. lectularius and R. prolixus belong to two different families of Hemiptera that evolved independently to blood feeding, a case is made for the convergent evolution of these two insect nitrophorins.
KW  - amino acid sequences
KW  - biochemistry
KW  - complementary DNA
KW  - molecular genetics
KW  - myo-inositol
KW  - nitric oxide
KW  - nucleotide sequences
KW  - proteins
KW  - purification
KW  - saliva
KW  - salivary glands
KW  - Cimex lectularius
KW  - Cimicidae
KW  - Hemiptera
KW  - Rhodnius prolixus
KW  - Cimex
KW  - Cimicidae
KW  - Heteroptera
KW  - Hemiptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Rhodnius
KW  - Triatominae
KW  - Reduviidae
KW  - bed bug
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - inositol
KW  - meso-inositol
KW  - nitrophorins
KW  - protein sequences
KW  - salivary secretions
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506636&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The Ld Cht1 gene encodes the secretory chitinase of the human pathogen Leishmania donovani.
AU  - Shakarian, A. M.
AU  - Dwyer, D. M.
JO  - Gene
JF  - Gene
Y1  - 1998///
VL  - 208
IS  - 2
SP  - 315
EP  - 322
SN  - 0378-1119
AD  - Shakarian, A. M.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990805414.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9001-06-3.  Subject Subsets: Protozoology
N2  - Leishmania donovani promastigotes were shown to release chitinase activity during growth in vitro. A polymerase chain reaction (PCR)-based strategy identified a single copy open reading frame capable of encoding the L. donovani chitinase (Ld Chtl, 1374 bp). Ld Chtl was shown to be actively transcribed by L. donovani promastigotes using reverse transcription and PCR amplification. The deduced amino acid sequence of Ld Chtl showed high conservation to known chitinases including the putative active and 2 substrate binding sites. Antiserum generated against 4 peptides derived from its deduced amino acid sequence immunoprecipitated an ~ 50-kDa in vitro transcription/translation product of Ld Chtl. This antiserum also immunoprecipitated both the native L. donovani 50-kDa Chtl protein and the native chitinase activity synthesized and released by these parasites.
KW  - amino acid sequences
KW  - binding
KW  - chitinase
KW  - DNA amplification
KW  - enzyme activity
KW  - enzymes
KW  - genes
KW  - in vitro
KW  - molecular genetics
KW  - open reading frames
KW  - parasites
KW  - polymerase chain reaction
KW  - promastigotes
KW  - reverse transcription
KW  - transcription
KW  - Leishmania donovani
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA transcription
KW  - immunoprecipitation
KW  - ORFs
KW  - PCR
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Advances in prevention and treatment of infectious complications in children and adolescents with cancer. / Fortschritte in Prävention und Therapie infektiöser Komplikationen bei Kindern und Jugendlichen mit neoplastischen Erkrankungen.
AU  - Groll, A. H.
AU  - Müller, F. M. C.
JO  - Klinische Pädiatrie
JF  - Klinische Pädiatrie
Y1  - 1998///
VL  - 210
IS  - 3
SP  - 106
EP  - 114
SN  - 0300-8630
AD  - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992000992.  Publication Type: Journal Article.  Language: German.  Language of Summary: English.  Number of References: 34 ref.
N2  - This article first delineates both clinical approach and current treatment strategies in the paediatric cancer patient presenting with neutropenia and fever of unknown origin. Diagnosis and treatment of the most common specific infections (caused by bacteria, fungi and viruses) are reviewed and preventive measures in the setting of anticancer treatment are discussed.
KW  - adolescents
KW  - bacterial diseases
KW  - children
KW  - clinical aspects
KW  - complications
KW  - diagnosis
KW  - disease prevention
KW  - fever
KW  - human diseases
KW  - immunocompromised hosts
KW  - mycoses
KW  - neoplasms
KW  - neutropenia
KW  - opportunistic infections
KW  - reviews
KW  - treatment
KW  - viral diseases
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - cancers
KW  - clinical picture
KW  - pyrexia
KW  - teenagers
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000992&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lipid formulations of amphotericin B: clinical perspectives for the management of invasive fungal infections in children with cancer.
AU  - Groll, A. H.
AU  - Müller, F. M. C.
AU  - Piscitelli, S. C.
AU  - Walsh, T. J.
JO  - Klinische Pädiatrie
JF  - Klinische Pädiatrie
Y1  - 1998///
VL  - 210
IS  - 4
SP  - 264
EP  - 273
SN  - 0300-8630
AD  - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991200565.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 86 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The clinical pharmacokinetics, safety and efficacy of lipid formulations of amphotericin B are reviewed with special emphasis on paediatric data. A rational framework is provided for the determination of the current role of these formulations in patients with cancer and proven or suspected invasive fungal infections.
KW  - amphotericin B
KW  - application methods
KW  - children
KW  - drug formulations
KW  - drug therapy
KW  - efficacy
KW  - immunocompromised hosts
KW  - lipids
KW  - mycoses
KW  - neoplasms
KW  - opportunistic infections
KW  - pharmacokinetics
KW  - reviews
KW  - safety
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - chemotherapy
KW  - lipins
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200565&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of Friend virus replication by a compound that reacts with the nucleocapsid zinc finger: anti-retroviral effect demonstrated in vivo.
AU  - Ott, D. E.
AU  - Hewes, S. M.
AU  - Alvord, W. G.
AU  - Henderson, L. E.
AU  - Arthur, L. O.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1998///
VL  - 243
IS  - 2
SP  - 283
EP  - 292
SN  - 0042-6822
AD  - Ott, D. E.: AIDS Vaccine Program, SAIC/Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 211702-1201, USA.
N1  - Accession Number: 19982006900.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref. Registry Number: 7440-66-6. 
KW  - antiviral properties
KW  - coat proteins
KW  - human diseases
KW  - nucleocapsid proteins
KW  - replication
KW  - viral replication
KW  - zinc
KW  - Murine leukemia virus
KW  - Retroviridae
KW  - viruses
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - anti-viral properties
KW  - capsid proteins
KW  - murine leukaemia virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006900&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Polymorphism in the 3′ untranslated region of MTG8 is associated with obesity in Pima Indian males.
AU  - Wolford, J. K.
AU  - Bogardus, C.
AU  - Prochazka, M.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1998///
VL  - 246
IS  - 3
SP  - 624
EP  - 626
SN  - 0006-291X
AD  - Wolford, J. K.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19991402247.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
KW  - anthropometric dimensions
KW  - ethnic groups
KW  - genes
KW  - genetic polymorphism
KW  - genetics
KW  - obesity
KW  - polymorphism
KW  - sex differences
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anthropometric measurements
KW  - fatness
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Genetics (General and Theoretical) (ZZ370) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991402247&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunoprotective determinants in Friend murine leukemia virus envelope protein.
AU  - Hasenkrug, K. J.
AU  - Brooks, D. M.
AU  - Robertson, M. N.
AU  - Srinivas, R. V.
AU  - Chesebro, B.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1998///
VL  - 248
IS  - 1
SP  - 66
EP  - 73
SN  - 0042-6822
AD  - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH903 South 4th St., Hamilton, MT 59840, USA.
N1  - Accession Number: 19982012125.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
KW  - animal models
KW  - envelope proteins
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunity
KW  - immunization
KW  - protection
KW  - vaccines
KW  - man
KW  - Murine leukemia virus
KW  - Retroviridae
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Gammaretrovirus
KW  - human immunodeficiency virus
KW  - immune sensitization
KW  - murine leukaemia virus
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mapping of a neurovirulence determinant within the envelope protein of a polytropic murine retrovirus: induction of central nervous system disease by low levels of virus.
AU  - Poulsen, D. J.
AU  - Robertson, S. J.
AU  - Favara, C. A.
AU  - Portis, J. L.
AU  - Chesebro, B. W.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1998///
VL  - 248
IS  - 2
SP  - 199
EP  - 207
SN  - 0042-6822
AD  - Poulsen, D. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 South 4th Street, Hamilton, MT 59840, USA.
N1  - Accession Number: 19982013910.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref.
KW  - central nervous system
KW  - ENV gene
KW  - envelope proteins
KW  - nervous system
KW  - pathogenesis
KW  - virulence
KW  - Murine leukemia virus
KW  - Retroviridae
KW  - Gammaretrovirus
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - CNS
KW  - murine leukaemia virus
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013910&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Macaques infected with cloned simian immunodeficiency virus show recurring nef gene alterations.
AU  - Heidecker, G.
AU  - Muñoz, H.
AU  - Lloyd, P.
AU  - Hodge, D.
AU  - Ruscetti, F. W.
AU  - Morton, W. R.
AU  - Hu, S. L.
AU  - Benveniste, R. E.
JO  - Virology (New York)
JF  - Virology (New York)
Y1  - 1998///
VL  - 249
IS  - 2
SP  - 260
EP  - 274
SN  - 0042-6822
AD  - Heidecker, G.: Intramural Research Support Program, SIAC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
N1  - Accession Number: 19982014298.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref.
N2  - The molecular clone of SIV/Mne used in this study has no obvious inactivating mutations in the nef gene and was obtained from a single-cell clone of infected Hut 78 cells that produced high levels of infectious virus. It was hypothesized that the virus had acquired attenuating missense mutations in nef, which should be reverted in vivo, thus highlighting residues that are important for Nef function. To test this hypothesis, nef sequences obtained from macaques that had been inoculated with biologically (single-cell clone) or molecularly cloned SIV/Mne were analysed. It was found that 5 Nef residues had undergone consistent substitutions in almost all sequences isolated late in infection from the animal studied. In addition, other residues were found to have changed in more than one animal. The macaque-adapted nef conferred increased infectivity to the virus, but mutated versions rapidly accumulated in a tissue culture environment.
KW  - animal models
KW  - human diseases
KW  - mutations
KW  - NEF gene
KW  - tissue culture
KW  - Human immunodeficiency virus 1
KW  - Macaca
KW  - simian immunodeficiency virus
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus type 1
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, serotypes Ogawa and Inaba.
AU  - Wang Jian
AU  - Villeneuve, S.
AU  - Zhang Jian
AU  - Lei PingSheng
AU  - Miller, C. E.
AU  - Lafaye, P.
AU  - Nato, F.
AU  - Szu, S. C.
AU  - Karpas, A.
AU  - Bystricky, S.
AU  - Robbins, J. B.
AU  - Kováč, P.
AU  - Fournier, J. M.
AU  - Glaudemans, C. P. J.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1998///
VL  - 273
IS  - 5
SP  - 2777
EP  - 2783
SN  - 0021-9258
AD  - Wang Jian: Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982007552.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 308067-58-5.  Subject Subsets: Tropical Diseases
N2  - Monoclonal antibodies (IgG1s S-20-4, A-20-6 and IgA 2D6) directed against V. cholerae O1 Ogawa-lipopolysaccharide (LPS) exhibited the same fine specificities and similar affinities for synthetic mono- to hexasaccharides which mimicked the Ogawa O-polysaccharide (O-PS). They did not react with the corresponding synthetic fragments of Inaba O-PS. Binding studies using derivatives of the Ogawa monosaccharide and IgGs S-20-4 and A-20-6 revealed that the C-2 O-methyl group fits into a somewhat flexible antibody cavity and that hydrogen bonds involving the oxygen and, respectively, the OH at the 2- and 3-position of the sugar moiety as well as the 2′-position in the amide side chain are required. Monoclonal IgA ZAC-3 and IgG3 I-24-2 are specific for V. cholerae O1 serotypes Ogawa/Inaba-LPS. The former did not show binding with members of either series of the synthetic ligands related to the O-antigens of the Ogawa or Inaba serotypes, in agreement with its reported specificity for the lipid/core region. Inhibition studies revealed that the binding of purified IgG3 I-24-2 to Ogawa-LPS might be mediated by a region in the junction of the OPS to the lipid-core region of the LPS. cDNA cloning and analysis of the anti-Ogawa antibodies S-20-4, A-20-6, and 2D6 revealed a very high degree of homology among the heavy chains. Among the light chains, no such homology between S-20-4 and A-20-6 on the one hand, and 2D6 on the other hand, existed. For the anti-Inaba/Ogawa antibodies I-24-2 and ZAC-3, heavy chains were completely different, with some homology among the light chains.
KW  - antibodies
KW  - antigens
KW  - bacterial antigens
KW  - bacterial diseases
KW  - epitopes
KW  - human diseases
KW  - IgA
KW  - IgG
KW  - immunology
KW  - lipopolysaccharides
KW  - monoclonal antibodies
KW  - serotypes
KW  - Vibrio cholerae
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - antigenic determinants
KW  - antigenicity
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007552&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hemoglobin induces binding of several extracellular matrix proteins to Candida albicans. Identification of a common receptor for fibronectin, fibrinogen, and laminin.
AU  - Yan SiZhuang
AU  - Rodrigues, R. G.
AU  - Cahn-Hidalgo, D.
AU  - Walsh, T. J.
AU  - Roberts, D. D.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1998///
VL  - 273
IS  - 10
SP  - 5638
EP  - 5644
SN  - 0021-9258
AD  - Yan SiZhuang: Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19981201961.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Haemoglobin induced binding of laminin, fibrinogen and type IV collagen but not of thrombospondin-1 or type I collagen to C. albicans is reported. The binding of each protein was inhibited by the respective unlabelled ligand in a concentration-dependent manner. Fibrinogen inhibited the binding of radiolabelled fibronectin, laminin and fibrinogen with similar IC50 values, indicating that a single promiscuous receptor recognises these 3 proteins. Competitive binding studies demonstrated that a second class of receptor binds specifically to laminin. Growth of C. albicans in the presence of haemoglobin also increased cell adhesion to immobilized fibronectin, laminin, fibrinogen and type IV collagen but not to thrombospondin-1 or type I collagen. Exposure to haemoglobin induced increased or de novo expression of several surface proteins on C. albicans. One of these proteins with a molecular weight of 55 000 recognised fibronectin, based on ligand protection and affinity chromatography on immobilized fibronectin. It is concluded that haemoglobin induces both promiscuous and specific receptors for extracellular matrix proteins and, therefore, may regulate matrix adhesion during dissemination of C. albicans infections.
KW  - adhesion
KW  - candidosis
KW  - collagen
KW  - haemoglobin
KW  - matrix proteins
KW  - pathogenesis
KW  - Candida albicans
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - candidiasis
KW  - fibronectin
KW  - fungus
KW  - hemoglobin
KW  - Hyphomycetes
KW  - laminin
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat.
AU  - Benkirane, M.
AU  - Chun, R. F.
AU  - Xiao Hua
AU  - Ogryzko, V. V.
AU  - Howard, B. H.
AU  - Nakatani, Y.
AU  - Jeang KuanTeh
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1998///
VL  - 273
IS  - 38
SP  - 24898
EP  - 24905
SN  - 0021-9258
AD  - Benkirane, M.: Bldg. 4, Rm. 306, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19982013769.  Publication Type: Journal Article.  Language: English.  Number of References: 90 ref. Registry Number: 63231-63-0. 
N2  - This study shows that a nuclear histone acetyltransferase activity associates with Tat. Intracellularly, Tat formed a ternary complex with p300 and P/CAF, 2 histone acetyltransferases (HATs). A murine cell defect in Tat transactivation of the HIV-1 LTR was linked to the reduced abundance of p300 and P/CAF. Thus, overexpression of p300 and P/CAF reconstituted Tat transactivation of the HIV-1 LTR in NIH3T3 cells to a level similar to that observed for human cells. By the use of transdominant p300 or P/CAF mutants that lack enzymatic activity, a requirement was delineated for the HAT component from the latter but not the former in Tat function. Finally, it was observed that Tat-associated HAT is preferentially important for transactivation of integrated, but not integrated, HIV-1 LTR.
KW  - chromosomes
KW  - hosts
KW  - human diseases
KW  - integration
KW  - mutants
KW  - proviruses
KW  - RNA
KW  - Tat protein
KW  - transactivation
KW  - transcription
KW  - Human immunodeficiency virus 1
KW  - Retroviridae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - DNA transcription
KW  - histone acetyltransferase
KW  - human immunodeficiency virus type 1
KW  - ribonucleic acid
KW  - transcriptional activation
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius: a new type of nucleotide-binding enzyme.
AU  - Valenzuela, J. G.
AU  - Charlab, R.
AU  - Galperin, M. Y.
AU  - Ribeiro, J. M. C.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1998///
VL  - 273
IS  - 46
SP  - 30583
EP  - 30590
SN  - 0021-9258
AD  - Valenzuela, J. G.: Medical Entomology Section, Laboratory of Parasitic Diseases, NIAID, Bldg. 4, Rm. 126, 4 Center Dr., MSC 0425, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990500651.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - An enzyme that hydrolyzes the phosphodiester bonds of nucleoside tri- and diphosphates, but not monophosphates, thus displaying apyrase (EC 3.6.1.5) activity, was purified from salivary glands of C. lectularius. The purified C. lectularius apyrase was an acidic protein with a pI of 5.1 and molecular mass of ~40 kDa that inhibited ADP-induced platelet aggregation and hydrolyzed platelet agonist ADP with specific activity of 379 units/mg protein. Amplification of C. lectularius cDNA corresponding to the N-terminal sequence of purified apyrase produced a probe that allowed identification of a 1.3 kilobase pair cDNA clone coding for a protein of 364 amino acid residues, the first 35 of which constituted the signal peptide. The processed form of the protein was predicted to have a molecular mass of 37.5 kDa and pI of 4.95. The identity of the product of the cDNA clone with native C. lectularius apyrase was proved by immunological testing and by expressing the gene in a heterologous host. Immune serum made against a synthetic peptide with sequence corresponding to the C-terminal region of the predicted cDNA clone recognized both C. lectularius apyrase fractions eluted from a molecular sieving high pressure liquid chromatography and the apyrase active band from chromatofocusing gels. Furthermore, transfected COS-7 cells secreted a Ca2+-dependent apyrase with a pI of 5.1 and immunoreactive material detected by the anti-apyrase serum. C. lectularius apyrase has no significant sequence similarity to any other known apyrases, but homologous sequences have been found in the genome of Caenorhabditis elegans and in mouse and human expressed sequence tags from foetal and tumour EST libraries.
KW  - amino acid sequences
KW  - clones
KW  - complementary DNA
KW  - enzymes
KW  - gene expression
KW  - genomes
KW  - molecular genetics
KW  - nucleotide sequences
KW  - salivary glands
KW  - Cimex lectularius
KW  - Cimicidae
KW  - Hemiptera
KW  - Cimex
KW  - Cimicidae
KW  - Heteroptera
KW  - Hemiptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - apyrase
KW  - bed bug
KW  - biochemical genetics
KW  - cDNA
KW  - cloning
KW  - DNA sequences
KW  - protein sequences
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Strain-dependent differences in β-sheet conformations of abnormal prion protein.
AU  - Caughey, B.
AU  - Raymond, G. J.
AU  - Bessen, R. A.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1998///
VL  - 273
IS  - 48
SP  - 32230
EP  - 32235
SN  - 0021-9258
AD  - Caughey, B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA.
N1  - Accession Number: 19992202865.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - Strain diversity in transmissible spongiform encephalopathies (TSEs) is thought to be caused by variations in the conformation of the abnormal, protease-resistant form of prion protein (PrP-res). The infection of hamsters with three TSE strains was investigated to see if it resulted in the formation of PrP-res with different conformations using limited proteinase K (PK) digestion and infrared spectroscopy. PrP-res isolated from the brains of hamsters infected with the hyper (HY), drowsy (DY), and 263K TSE strains of transmissible mink encephalopathy yielded similar SDS-PAGE profiles before PK treatment. However, after limited digestion with PK, the PrP-res from the DY strain exhibited a fragmentation pattern that was distinct from that of the other two strains. Infrared spectra of HY and 263K Pr-Pres each had major absorption bands in the amide I region at 1626 and 1636 cm-1 both before and after digestion with PK. These bands were not evident in the DY PrP-res spectra, which had a unique band at 1629-1630 cm-1 and stronger band intensity at both 1616 and 1694-1695 cm-1. Because absorbances from 1616 to 1636 cm-1 of protein infrared spectra are attributed primarily to β-sheet structures, these findings indicate that the conformations of HY and 263K PrP-res differ from DY PrP-res at least in structural regions with β-sheet secondary structure. These results support the hypothesis that strain-specific PrP-res conformers can self-propagate by converting the normal prion protein to the abnormal conformers that induce phenotypically distinct TSE diseases.
KW  - electrophoresis
KW  - pathogenesis
KW  - prions
KW  - spongiform encephalopathy
KW  - hamsters
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Whole body fat oxidation is related to in situ adipose tissue lipolytic response to isoproterenol in males.
AU  - Snitker, S.
AU  - Hellmér, J.
AU  - Boschmann, M.
AU  - Monroe, M. B.
AU  - Ravussin, E.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1998///
VL  - 275
IS  - 3
SP  - E400
EP  - E404
SN  - 0002-9513
AD  - Snitker, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
N1  - Accession Number: 19981416234.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 299-95-6, 51-30-9, 6700-39-6, 76853-59-2.  Subject Subsets: Human Nutrition
N2  - To determine whether impaired fat mobilization (lipolysis) may contribute to weight gain, the relation between lipolytic response to nonselective β-adrenergic stimulation and respiratory quotient (RQ) measured in a respiratory chamber was examined in 21 men (11 Caucasians, 10 Pima Indians; 32±5 years, weight 93±24 kg, body fat 30±8%) and 23 women (10 Caucasians, 13 Pima Indians; 32±9 years, weight 95±26 kg, body fat 44±8%). Lipolytic response was assessed as the relative increase in dialysate glycerol concentration (% above baseline) when isoproterenol (1 µmol/litre) was added to the perfusate of a microdialysis probe inserted in the abdominal subcutaneous adipose tissue. In men only, basal RQ measured during sleep from 0500 to 0630 h and adjusted for waist circumference was negatively correlated to lipolytic response (r=-0.66, P=0.001). The results suggest that in men, impaired β-adrenergic-mediated lipolysis may contribute to low rates of fat oxidation, a condition known to predispose to weight gain.
KW  - adipose tissue
KW  - beta-adrenergic agonists
KW  - body fat
KW  - ethnicity
KW  - isoprenaline
KW  - lipid metabolism
KW  - lipolysis
KW  - men
KW  - oxidation
KW  - respiratory quotient
KW  - sex differences
KW  - weight gain
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ethnic differences
KW  - fat metabolism
KW  - isoproterenol
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV vaccines: prospects and challenges.
AU  - Baltimore, D.
AU  - Heilman, C.
JO  - Scientific American
JF  - Scientific American
Y1  - 1998///
VL  - 279
IS  - 1
SP  - 78
EP  - 83
SN  - 0036-8733
AD  - Baltimore, D.: National Institutes of Health AIDS Vaccine Research Committee, USA.
N1  - Accession Number: 19982012252.  Publication Type: Journal Article.  Language: English. 
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - research
KW  - reviews
KW  - vaccines
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - immunity reactions
KW  - immunological reactions
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates.
AU  - Strickler, H. D.
AU  - Rosenberg, P. S.
AU  - Devesa, S. S.
AU  - Hertel, J.
AU  - Fraumeni, J. F., Jr.
AU  - Goedert, J. J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1998///
VL  - 279
IS  - 4
SP  - 292
EP  - 295
SN  - 0098-7484
AD  - Strickler, H. D.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19982007930.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Public Health
N2  - To determine the risk of ependymoma, osteosarcoma and mesothelioma among individuals in the USA, who as children received SV40 virus-contaminated poliovirus vaccine (used extensively between 1955 and 1963), a retrospective cohort study was conducted using data from the Surveillance, Epidemiology and End Results programme (1973-93), the Connecticut Tumor Registry (1950-69) and national mortality statistics (1947-73). Birth cohorts were grouped for analysis according to those likely to have received SV40-contaminated poliovirus vaccine as infants (born during 1956-62; 60 811 730 person-years of observation), or as children (born during 1947-52; 46 430 953 person-years) and birth cohorts that were unexposed (born during 1964-69; 44 959 979 person-years). Age-specific cancer rates were generally low. Compared with the unexposed, the relative risk (RR) of ependymoma and osteosarcoma was not increased in the cohorts exposed as infants (RR 1.06; 95% confidence interval (CI), 0.69-1.63 and RR 0.87; 95% CI 0.71-1.06, respectively), or as children (RR 0.98; 95% CI 0.57-1.69 and RR 0.85; 95% CI 0.59-1.22, respectively), nor did the exposed have an increased risk of all brain cancers. Mesotheliomas showed a non-significant increase associated with exposure, although the cohorts studied had not yet reached the age at which these tumours tend to occur, resulting in imprecise estimates of risk.
KW  - adverse effects
KW  - children
KW  - contamination
KW  - infants
KW  - neoplasms
KW  - vaccines
KW  - Connecticut
KW  - USA
KW  - man
KW  - Poliovirus
KW  - Polyomavirus
KW  - simian virus 40
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Enterovirus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Polyomavirus
KW  - simian polyomaviruses
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - cancers
KW  - human poliovirus
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Chemokine receptors and genetic variability. Another leap in HIV research.
AU  - O'Brien, T. R.
AU  - Goedert, J. J.
T2  - JAMA, Journal of the American Medical Association
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1998///
VL  - 279
IS  - 4
SP  - 317
EP  - 318
SN  - 0098-7484
AD  - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, US Public Health Service, US Department of Health and Human Services, EPN 434, 6130 Executive Blvd., National Institutes of Health, North Bethesda, MD 20852, USA.
N1  - Accession Number: 19982008867.  Publication Type: Editorial.  Language: English.  Number of References: 25 ref. Registry Number: 63231-63-0. 
N2  - A brief overview is given of advances in HIV-1 and chemokine receptor research, from the discovery of the effect of the chemokines, RANTES, macrophage inflammatory protein-1 alpha (MIP-1α) and MIP-1β, on macrophage-tropic HIV strains in 1995 to the most recent research on genetic determinants of disease prognosis, such as the effect of CCR5Δ32 deletion reported in the same issue by M. Misrahi et al. (JAMA (1998), 279, 277-280) and also CCR2-64I. It is anticipated that the insights into the role of chemokine receptors in HIV-1 infection will enable new therapeutic approaches.
KW  - acquired immune deficiency syndrome
KW  - alleles
KW  - chemokines
KW  - children
KW  - cytokines
KW  - disease course
KW  - genetic variation
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - maternal transmission
KW  - mortality
KW  - pathogenesis
KW  - protection
KW  - receptors
KW  - research
KW  - RNA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - death rate
KW  - disease progression
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - ribonucleic acid
KW  - studies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008867&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment and vaccination strategies to control cholera in sub-Saharan refugee settings. A cost-effectiveness analysis.
AU  - Naficy, A.
AU  - Rao, M. R.
AU  - Paquet, C.
AU  - Antona, D.
AU  - Sorkin, A.
AU  - Clemens, J. D.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1998///
VL  - 279
IS  - 7
SP  - 521
EP  - 525
SN  - 0098-7484
AD  - Naficy, A.: National Institute of Child Health and Human Development, Room 7B03, 6100 Executive Blvd., Bethesda, MD 20892, USA.
N1  - Accession Number: 19982009970.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Tropical Diseases; Rural Development
N2  - A cost-effectiveness analysis was conducted, based on probabilities of cholera outcomes derived from epidemiological data compiled for refugee settings in Malawi during 1987-93; data for costs were obtained from a large relief agency that provides medical care in such settings. The setting was a hypothetical refugee camp with 50 000 persons in sub-Saharan Africa, evaluated for a 2-year period. The costs and outcomes were compared for alternative strategies in which appropriate rehydration therapy for cholera is introduced preemptively (at the establishment of a camp) or reactively (once an epidemic is recognized) and in which mass immunization with oral B subunit killed whole-cell (BS-WC) cholera vaccine is added to a rehydration programme either preemptively or reactively. The main outcome measures were cost per cholera case prevented and cost per cholera death averted. It was calculated that in a situation with no available rehydration therapy suitable for the management of severe cholera, preemptive therapy (US$320 per death averted) costs less and is more effective than reactive therapy (US$586 per death averted). Adding vaccination to preemptive therapy was expensive: US$1745 per additional death averted for preemptive vaccination and US$3833 per additional death averted for reactive vaccination. However, if the cost of vaccine decreases to &lt;US$0.22 per dose, strategies combining vaccination and preemptive therapy become more cost-effective than therapy alone.
KW  - cholera
KW  - cost benefit analysis
KW  - costs
KW  - disease control
KW  - human diseases
KW  - immunization
KW  - oral rehydration therapy
KW  - refugees
KW  - rural development
KW  - vaccination
KW  - Africa South of Sahara
KW  - Malawi
KW  - man
KW  - Vibrio cholerae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Africa
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - bacterium
KW  - costings
KW  - immune sensitization
KW  - Nyasaland
KW  - ORT
KW  - subsaharan Africa
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Other Control Measures (HH700) 
KW  - Demography (UU200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009970&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Trends in HIV incidence among young adults in the United States.
AU  - Rosenberg, P. S.
AU  - Biggar, R. J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1998///
VL  - 279
IS  - 23
SP  - 1894
EP  - 1899
SN  - 0098-7484
AD  - Rosenberg, P. S.: Biostatistics Branch, National Cancer Institute, 6130 Executive Blvd, EPN/403, Rockville, MD 20892, USA.
N1  - Accession Number: 19982013109.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
N2  - As of January 1993, about 22 000 men and 11 000 women aged 18 to 22 years were living with HIV infection in the USA. Homosexual contact was the leading route of infection among young men. Heterosexual contact was the leading route of infection among young women. The HIV incidence attributed to homosexual contact or injection drug use decreased among persons aged 20 and 25 years between 1988 and 1993, but HIV incidence attributed to heterosexual contact was stable or increasing. Notably, in men aged 20 and 25 years, HIV prevalence declined by about 50% in white men but was relatively stable in black and Hispanic men. In contrast, HIV prevalence in women aged 20 and 25 years rose by 36% and 45%, respectively, because of increasing heterosexual transmission. Overall, HIV prevalence in persons aged 20 and 25 years declined by only 14% between 1988 and 1993.
KW  - acquired immune deficiency syndrome
KW  - adolescents
KW  - adults
KW  - children
KW  - drug abuse
KW  - drug users
KW  - epidemiology
KW  - heterosexual transmission
KW  - heterosexuality
KW  - Hispanics
KW  - HIV infections
KW  - homosexuality
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - incidence
KW  - injecting drug users
KW  - men
KW  - minorities
KW  - transmission
KW  - trends
KW  - women
KW  - youth
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - drug abusers
KW  - drug use
KW  - heterosexuals
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - i.v. drug abusers
KW  - i.v. drug users
KW  - intravenous drug users
KW  - teenagers
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Social Structure (UU480) (Discontinued March 2000)
KW  - Women (UU500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant.
AU  - Winkler, C.
AU  - Modi, W.
AU  - Smith, M. W.
AU  - Nelson, G. W.
AU  - Wu XueYun
AU  - Carrington, M.
AU  - Dean, M.
AU  - Honjo, T.
AU  - Tashiro, K.
AU  - Yabe, D.
AU  - Buchbinder, S.
AU  - Vittinghoff, E.
AU  - Goedert, J. J.
AU  - O'Brien, T. R.
AU  - Jacobson, L. P.
AU  - Detels, R.
AU  - Donfield, S.
AU  - Willoughby, A.
AU  - Gomperts, E.
AU  - Vlahov, D.
AU  - Phair, J.
AU  - O'Brien, S. J.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1998///
VL  - 279
IS  - 5349
SP  - 389
EP  - 393
SN  - 0036-8075
AD  - Winkler, C.: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA.
N1  - Accession Number: 19982002981.  Publication Type: Journal Article.  Corporate Author: ALIVE Study; Multicenter AIDS Cohort Study; Multicenter Hemophilia Cohort Study; San Francisco City Cohort Language: English.  Number of References: 47 ref.
N2  - Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line-tropic HIV-1. A common polymorphism, SDF1-3′A, was identified in an evolutionarily conserved segment of the 3′ untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3′A/3′A delays the onset of AIDS, according to a genetic association analysis of 2857 patients enrolled in 5 AIDS cohort studies. The recessive protective effect of SDF1-3′A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.
KW  - acquired immune deficiency syndrome
KW  - CD4 antigens
KW  - chemokines
KW  - cytokines
KW  - disease course
KW  - effects
KW  - genes
KW  - genetic variation
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - lymphocytes
KW  - mutations
KW  - pathogenesis
KW  - patients
KW  - protection
KW  - receptors
KW  - strains
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - CD4
KW  - disease progression
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002981&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy.
AU  - Schrager, L. K.
AU  - D'Souza, M. P.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1998///
VL  - 280
IS  - 1
SP  - 67
EP  - 71
SN  - 0098-7484
AD  - Schrager, L. K.: Epidemiology Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Bldg 2C10, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982011437.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
N2  - The eradication of HIV-1 from infected persons is the ultimate goal of HIV therapeutic interventions. Great strides have been made in developing potent antiretroviral regimens that greatly suppress HIV-1 replication. Despite these therapeutic advances, major obstacles remain to eradicating HIV-1. Reservoirs of HIV-1 have been identified that represent major impediments to eradication. Conceptually, there are 2 types of sanctuaries for HIV-1, cellular and anatomical. Cellular sanctuaries may include latent CD4+ T cells containing integrated HIV-1 provirus; macrophages, which may express HIV-1 for prolonged periods; and follicular dendritic cells, which may hold infectious HIV-1 on their surfaces for indeterminate lengths of time. The key anatomical reservoir for HIV-1 appears to be the central nervous system. An understanding of the nature of HIV within these reservoirs is critical to devising strategies to hasten viral eradication.
KW  - antiviral agents
KW  - central nervous system
KW  - combination therapy
KW  - disease control
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - latent infections
KW  - leukocytes
KW  - macrophages
KW  - reviews
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - CNS
KW  - combined modality therapy
KW  - follicular dendritic cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - leucocytes
KW  - multimodal treatment
KW  - T cells
KW  - white blood cells
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011437&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The National Cholesterol Education Program. Progress and prospects.
AU  - Cleeman, J. I.
AU  - Lenfant, C.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1998///
VL  - 280
IS  - 24
SP  - 2099
EP  - 2104
SN  - 0098-7484
AD  - Cleeman, J. I.: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, 31 Center Dr, Bldg 31, Room 4A16, Bethesda, MD 20892-2480, USA.
N1  - Accession Number: 19991401792.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 57-88-5.  Subject Subsets: Human Nutrition
N2  - The review looks at The National Cholesterol Education Programme (NCEP) and the role it has played over the last 50 years. Since 1985, the NCEP has adhered to 2 principles: mounting educational campaigns for professionals and the public; building on a strong science base and working in partnership with other organizations. Progress has been made in reducing blood cholesterol and increasing cholesterol awareness. The impact of cholesterol education is clearly visible in 4 major trends: increasing professional and public cholesterol awareness; declining dietary intakes of saturated fat, total fat, and cholesterol; falling serum cholesterol levels; and a continuing decline in coronary heart disease (CHD) mortality rates. Nevertheless, cholesterol levels are still being undertreated, especially in patients with CHD, and substantial scientific and educational challenges remain. As the NCEP looks forward to the 21st century, they plan to make continued progress by using emerging scientific developments and pursuing the powerful combination of cholesterol lowering in CHD patients and in primary prevention.
KW  - atherosclerosis
KW  - blood
KW  - cardiovascular diseases
KW  - cholesterol
KW  - diet
KW  - fats
KW  - heart diseases
KW  - nutrition education
KW  - nutrition programmes
KW  - prevention
KW  - reviews
KW  - saturated fats
KW  - serum
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - arteriosclerosis
KW  - coronary diseases
KW  - feeding programmes
KW  - feeding programs
KW  - food programs
KW  - nutrition programs
KW  - United States of America
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991401792&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The NIMH Multisite HIV Prevention Trial: reducing HIV sexual risk behaviour.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1998///
VL  - 280
IS  - 5371
SP  - 1889
EP  - 1894
SN  - 0036-8075
AD  - Multisite Staff Collaborator, National Institute of Mental Health, NIH, Parklawn Bldg., Rm 18-101, 5600 Fishers Lane, Rockville, MD 20897, USA.
N1  - Accession Number: 19982009762.  Publication Type: Journal Article.  Corporate Author: USA, National Institute of Mental Health (NIMH) Multisite HIV Prevention Group Language: English.  Number of References: 17 ref.
N2  - The efficacy of a behavioural intervention to reduce HIV risk behaviours was tested in a randomized, controlled trial with 3 high-risk populations at 37 clinics from 7 sites across the USA. Compared with the 1855 individuals in the control condition, the 1851 participants assigned to a small-group, 7-session HIV risk reduction programme reported fewer unprotected sexual acts, had higher levels of condom use, and were more likely to use condoms consistently over a 12-month follow-up period. On the basis of clinical record review, no difference in overall STD reinfection rate was found between intervention and control condition participants. However, among men recruited from STD clinics, those assigned to the intervention condition had a gonorrhoea incidence rate one half that of those in the control condition. Intervention condition participants also reported fewer STD symptoms over the 12-month follow-up period. Study outcomes suggest that behavioural interventions can reduce HIV-related sexual risk behaviour among low-income women and men served in public health settings. Studies that test strategies for reducing sexual risk behaviour over longer periods of time are needed, especially with populations that remain most vulnerable to HIV infection.
KW  - acquired immune deficiency syndrome
KW  - disease prevention
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - intervention
KW  - public health
KW  - risk reduction
KW  - sexual behaviour
KW  - sexually transmitted diseases
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - human immunodeficiency virus
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - sexually transmitted infections
KW  - STDs
KW  - United States of America
KW  - venereal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009762&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Bloodstream- versus tick-associated variants of a relapsing fever bacterium.
AU  - Schwan, T. G.
AU  - Hinnebusch, B. J.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1998///
VL  - 280
IS  - 5371
SP  - 1938
EP  - 1940
SN  - 0036-8075
AD  - Schwan, T. G.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19980506475.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The relapsing fever spirochaete Borrelia hermsii alternates infections between a mammal and a tick vector. Whether the spirochaete changes phenotypically in the different hosts was examined by allowing the tick Ornithodoros hermsi to feed on mice infected with serotype 7 or serotype 8 of B. hermsii. Upon infection of ticks, the spirochaetal serotype-specific variable major proteins (Vmps) 7 and 8 became undetectable and were replaced by Vmp33. This switch from a bloodstream- to tick-associated phenotype could be induced in culture by a decrease in temperature. After tick-bite transmission back to mice, the process was reversed and the spirochaetes resumed expression of the same Vmp present in the previous infectious blood meal.
KW  - disease vectors
KW  - ectoparasites
KW  - infections
KW  - laboratory animals
KW  - phenotypes
KW  - proteins
KW  - relapsing fever
KW  - temperature
KW  - tickborne relapsing fever
KW  - Acari
KW  - Arachnida
KW  - Borrelia hermsii
KW  - mice
KW  - Ornithodoros
KW  - Ornithodoros hermsi
KW  - spirochaetes
KW  - Arachnida
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Argasidae
KW  - Metastigmata
KW  - Acari
KW  - Ornithodoros
KW  - bacterium
KW  - variable major proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506475&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic acceleration of AIDS progression by a promoter variant of CCR5.
AU  - Martin, M. P.
AU  - Dean, M.
AU  - Smith, M. W.
AU  - Winkler, C.
AU  - Gerrard, B.
AU  - Michael, N. L.
AU  - Lee, B.
AU  - Doms, R. W.
AU  - Margolick, J.
AU  - Buchbinder, S.
AU  - Goedert, J. J.
AU  - O'Brien, T. R.
AU  - Hilgartner, M. W.
AU  - Vlahov, D.
AU  - O'Brien, S. J.
AU  - Carrington, M.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1998///
VL  - 282
IS  - 5395
SP  - 1907
EP  - 1911
SN  - 0036-8075
AD  - Martin, M. P.: Science Applications International Corporation (SAIC), National Cancer Institute, Frederick, MD 21702, USA.
N1  - Accession Number: 19992001155.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Public Health
N2  - Genetic association analysis of 5 cohorts of people with acquired immunodeficiency syndrome (AIDS) revealed that infected individuals homozygous for a multisite haplotype of the CCR5 regulatory region containing the promoter allele, CCR5P1, progress to AIDS more rapidly than those with other CCR5 promoter genotypes, particularly in the early years after infection. Composite genetic epidemiological analyses of genotypes bearing CCR5P1, CCR5-Δ32, CCR2-641 and SDF1-3′A affirmed distinct regulatory influences for each gene on AIDS progression. It is estimated that 10-17% of patients who develop AIDS within 3.5 years of human immunodeficiency virus type 1 (HIV-1) infection do so because they are homozygous for CCR5P1/P1, and that 7-13% of all people carry this susceptible genotype. It is concluded that the cumulative and interactive influence of these AIDS restriction genes illustrates the multigenic nature of host factors limiting AIDS disease progression.
KW  - acquired immune deficiency syndrome
KW  - alleles
KW  - disease course
KW  - epidemiology
KW  - genes
KW  - genotypes
KW  - homozygosity
KW  - human diseases
KW  - molecular genetics
KW  - pathogenesis
KW  - promoters
KW  - receptors
KW  - viral diseases
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - biochemical genetics
KW  - disease progression
KW  - human immunodeficiency virus type 1
KW  - promoter region
KW  - promoter sequences
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001155&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - "A calculated risk": the Salk polio vaccine field trials of 1954.
AU  - Meldrum, M.
JO  - British Medical Journal (Clinical Research edition)
JF  - British Medical Journal (Clinical Research edition)
Y1  - 1998///
VL  - 317
IS  - 7167
SP  - 1233
EP  - 1236
SN  - 0959-8138
AD  - Meldrum, M.: National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992000396.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref.
KW  - clinical trials
KW  - history
KW  - human diseases
KW  - immunization
KW  - inactivated vaccines
KW  - poliomyelitis
KW  - vaccination
KW  - vaccines
KW  - viral diseases
KW  - USA
KW  - man
KW  - Poliovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Enterovirus
KW  - Picornaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human poliovirus
KW  - immune sensitization
KW  - killed vaccines
KW  - polio
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000396&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - 1755 and all that: a historical primer of transmissible spongiform encephalopathy.
AU  - Brown, P.
AU  - Bradley, R.
JO  - British Medical Journal (Clinical Research edition)
JF  - British Medical Journal (Clinical Research edition)
Y1  - 1998///
VL  - 317
IS  - 7174
SP  - 1688
EP  - 1692
SN  - 0959-8138
AD  - Brown, P.: Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, Building 36, Room 5B20, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992201500.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Subject Subsets: Veterinary Science
N2  - A review of the history of prion diseases beginning with the first recorded mention of scrapie in sheep in 1755.
KW  - bovine spongiform encephalopathy
KW  - Creutzfeldt-Jakob disease
KW  - prion diseases
KW  - prions
KW  - scrapie
KW  - veterinary history
KW  - UK
KW  - cattle
KW  - man
KW  - sheep
KW  - Bos
KW  - Bovidae
KW  - ruminants
KW  - Artiodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Ovis
KW  - British Isles
KW  - Western Europe
KW  - Europe
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - bovine encephalopathy
KW  - Britain
KW  - BSE
KW  - mad cow disease
KW  - United Kingdom
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992201500&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly.
AU  - Vinetz, J. M.
AU  - Li Jun
AU  - McCutchan, T. F.
AU  - Kaslow, D. C.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1998///
VL  - 338
IS  - 6
SP  - 367
EP  - 371
SN  - 0028-4793
AD  - Vinetz, J. M.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 19980802478.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 59-05-2.  Subject Subsets: Protozoology; Public Health; Tropical Diseases
N2  - The case is reported of a 74-year-old Greek woman from the island of Karpathos who was found to have splenomegaly during a routine examination. The woman was asymptomatic and had never travelled outside Greece. Symptoms of malaria began after she was treated with methotrexate for lymphoma. Although blood smears were repeatedly negative, Plasmodium malariae infection was diagnosed by a polymerase chain reaction assay. Malaria had been eradicated in Greece by about 1950 and it was concluded that the patient had been infected for at least 40 and possibly as long as 70 years. The disease had remained latent until the patient was treated with an immunosuppressive agent.
KW  - antineoplastic agents
KW  - asymptomatic infections
KW  - case reports
KW  - diagnosis
KW  - human diseases
KW  - immunosuppressive agents
KW  - infections
KW  - latent infections
KW  - malaria
KW  - methotrexate
KW  - parasites
KW  - polymerase chain reaction
KW  - spleen
KW  - splenomegaly
KW  - Greece
KW  - man
KW  - Plasmodium malariae
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - Balkans
KW  - Southern Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - amethopterin
KW  - cytotoxic agents
KW  - immunosuppressants
KW  - PCR
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802478&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Transmission of multidrug-resistant human immunodeficiency virus-the wake-up call.
AU  - Cohen, O. J.
AU  - Fauci, A. S.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1998///
VL  - 339
IS  - 5
SP  - 341
EP  - 343
SN  - 0028-4793
AD  - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-2520, USA.
N1  - Accession Number: 19982011001.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref.
N2  - The availability of potent antiretroviral drugs capable of long-term suppression of HIV replication is a welcome advance that has rapidly improved the prognosis for HIV-infected persons; however, it must be anticipated that in all but exceptional cases, the virus will have sufficient genetic plasticity to develop drug resistance during periods of subtotal suppression of replication. Transmission of multidrug-resistant HIV will most likely occur with increasing frequency, and the wake-up call provided by the report of Hecht et al. (New Engl. Jour. Med. (1998) 339 307-311) should reinforce the lessons taught by the tubercle bacillus, Staphylococcus aureus, and Streptococcus pneumoniae. Appropriate prescription of potent antiretroviral regimens, maximal adherence to the regimen, the development of new drugs directed against different stages of the viral-replication cycle, and the creation of accurate and reliable assays to assess drug resistance are all essential for the successful long-term control of HIV replication.
KW  - antiviral agents
KW  - drug resistance
KW  - drug therapy
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - multiple drug resistance
KW  - replication
KW  - transmission
KW  - viral replication
KW  - man
KW  - Staphylococcus
KW  - Staphylococcus aureus
KW  - Streptococcus
KW  - Streptococcus pneumoniae
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Staphylococcaceae
KW  - Bacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Staphylococcus
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Streptococcus
KW  - Bacillus
KW  - bacterium
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Poxvirus dilemmas - monkeypox, smallpox, and biologic terrorism.
AU  - Breman, J. G.
AU  - Henderson, D. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1998///
VL  - 339
IS  - 8
SP  - 556
EP  - 559
SN  - 0028-4793
AD  - Breman, J. G.: National Institutes of Health, Bethesda, MD 20892-2220, USA.
N1  - Accession Number: 19982013157.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Tropical Diseases
N2  - This paper discusses whether recent outbreaks of human monkeypox in the Democratic Republic of the Congo (Zaire) could represent the return of another form of smallpox. Potential use of variola virus as a biological weapon in terrorism is considered together with the implications of the WHO decision to advise destruction of all isolates of the variola virus in June 1999.
KW  - biological warfare
KW  - epidemiology
KW  - human diseases
KW  - monkeypox
KW  - smallpox
KW  - terrorism
KW  - viral diseases
KW  - Congo Democratic Republic
KW  - man
KW  - monkeypox virus
KW  - variola virus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthopoxvirus
KW  - Chordopoxvirinae
KW  - Poxviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Francophone Africa
KW  - Least Developed Countries
KW  - Developing Countries
KW  - viral infections
KW  - Zaire
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013157&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Visceral abdominal-fat accumulation associated with use of indinavir.
AU  - Miller, K. D.
AU  - Jones, E.
AU  - Yanovski, J. A.
AU  - Shankar, R.
AU  - Feuerstein, I.
AU  - Falloon, J.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1998///
VL  - 351
IS  - 9106
SP  - 871
EP  - 875
SN  - 0140-6736
AD  - Miller, K. D.: National Institutes of Health (Bldg 10, Rm 8C410), Bethesda, MD 20892, USA.
N1  - Accession Number: 19982005590.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 150378-17-9.  Subject Subsets: Human Nutrition
N2  - The results of this study suggest that some HIV-1-infected patients on indinavir treatment accumulate intraabdominal fat that may cause abdominal symptoms. Recent evidence suggests that other HIV-1 protease inhibitors may be associated with changes in body-fat distribution. Larger studies of protease-inhibitor treatment are needed to investigate this association further and to investigate metabolic or endocrine mechanisms that may underlie this phenomenon. (However, see Lo et al.Lancet (1998) 351 867-870.)
KW  - abdomen
KW  - adverse effects
KW  - antiviral agents
KW  - body fat
KW  - human diseases
KW  - indinavir
KW  - proteinase inhibitors
KW  - symptoms
KW  - treatment
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adverse reactions
KW  - human immunodeficiency virus type 1
KW  - protease inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005590&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Failure of co-trimoxazole in Pneumocystis carinii infection and mutations in dihydropteroate synthase gene.
AU  - Mei Qin
AU  - Gurunathan, S.
AU  - Masur, H.
AU  - Kovacs, J. A.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1998///
VL  - 351
IS  - 9116
SP  - 1631
EP  - 1632
SN  - 0140-6736
AD  - Mei Qin: Critical Care Medicine Department, Clinical Center and Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, MD 20892-1662, USA.
N1  - Accession Number: 19981201922.  Publication Type: Journal Article.  Language: English.  Number of References: 5 ref. Registry Number: 8064-90-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - Cases are reported in 31- and 39-year-old HIV-positive men from the USA [dates not given] with P. carinii pneumonia, in whom prophylaxis or treatment with trimethoprim-sulfamethoxazole was unsuccessful. Mutations in the dihydropteroate synthase genes were identified in both patients.
KW  - acquired immune deficiency syndrome
KW  - antifungal agents
KW  - case reports
KW  - co-trimoxazole
KW  - drug resistance
KW  - drug therapy
KW  - genes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - lungs
KW  - men
KW  - mutations
KW  - mycoses
KW  - opportunistic infections
KW  - pneumocystosis
KW  - pneumonia
KW  - treatment
KW  - USA
KW  - fungi
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - chemotherapy
KW  - dihydropteroate synthase
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201922&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - A new classification for HIV-1.
AU  - Berger, E. A.
AU  - Doms, R. W.
AU  - Fenyö, E. M.
AU  - Korber, B. T. M.
AU  - Littman, D. R.
AU  - Moore, J. P.
AU  - Sattentau, Q. J.
AU  - Schuitemaker, H.
AU  - Sodroski, J.
AU  - Weiss, R. A.
T2  - Nature (London)
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1998///
VL  - 391
IS  - 6664
SP  - 240
EP  - 240
SN  - 0028-0836
AD  - Berger, E. A.: Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bldg 4, Rm 236, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982002986.  Publication Type: Correspondence.  Language: English.  Number of References: 10 ref.
N2  - It is proposed that isolates that use CCR5 but not CXCR4 be termed R5 viruses, that isolates using CXCR4 but not CCR5 be designated X4 viruses, and isolates able to use both co-receptors with comparable efficiency be called R5X4. Whether an X4 or R5X4 virus is a cell-line-adapted isolate should also be specified. Under this system, R5 viruses are the strains most commonly transmitted sexually, consistent with the high resistance of individuals lacking CCR5 to infection. After about 5 years, in about 50% of patients viruses evolve that are able to use CXCR4, with or without concurrent use of CCR5. These viruses would now be called R5X4 and X4 viruses, respectively. Isolates passaged through a permanent T-cell line should be called T-cell line-adapted (TCLA) X4 or R5X4 viruses, and a similar qualifier can be used for viruses adapted to growth in other cells. A record of co-receptor use by particular HIV-1, HIV-2 and SIV strains will be maintained by the Los Alamos National Laboratory Sequence Database, together with an expanded version of this article.
KW  - cell lines
KW  - chemokines
KW  - classification
KW  - cytokines
KW  - human diseases
KW  - laboratories
KW  - patients
KW  - receptors
KW  - strains
KW  - T lymphocytes
KW  - Human immunodeficiency virus 2
KW  - simian immunodeficiency virus
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - human immunodeficiency virus type 2
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002986&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antimutagenic and anticarcinogenic potentials of some Thai vegetables.
AU  - Kusamran, W. R.
AU  - Tepsuwan, A.
AU  - Kupradinun, P.
JO  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1  - 1998///
VL  - 402
IS  - 1/2
SP  - 247
EP  - 258
SN  - 0027-5107
AD  - Kusamran, W. R.: Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand.
N1  - Accession Number: 19981417613.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Human Nutrition
N2  - 15 commonly consumed Thai vegetables were extracted with hexane, chloroform and methanol, and tested for antimutagenic activities against direct-acting (AF-2 and NaN3) and indirect-acting (AFB1 and B(a)P) mutagens using Ames' mutagenicity test with Salmonella typhimurium TA100 as tester strain. Only the methanol extract of neem (Azadirachta indica) leaves contain weak antimutagen inhibiting the mutagenicities of both direct-acting mutagens. Interestingly, all vegetables studied contained compounds capable of inhibiting the mutagenicity of AFB1, while only some vegetables contain chemical compounds capable of inhibiting B(a)P. Bitter gourd (Momordica charantia), but not sweet basil (Ocimum basilicum), at 6.25 and 12.5% in the diet, partially inhibited DMBA-induced mammary gland carcinogenesis in female Sprague-Dawley rats when fed 2 weeks prior to DMBA. The results demonstrate that Thai vegetables contain antimutagens inhibiting the mutagenicity of some indirect-acting mutagen, particularly AFB1. The mechanism of their antimutagenicity may probably be the inhibition of the activity of metabolic-activating enzymes in the liver.
KW  - carcinogenesis
KW  - culinary herbs
KW  - enzymes
KW  - extracts
KW  - inhibition
KW  - liver
KW  - mammary gland neoplasms
KW  - mutagenesis
KW  - mutagens
KW  - vegetables
KW  - Thailand
KW  - Azadirachta indica
KW  - Momordica charantia
KW  - Ocimum basilicum
KW  - rats
KW  - Salmonella typhimurium
KW  - Azadirachta
KW  - Meliaceae
KW  - Sapindales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Momordica
KW  - Cucurbitaceae
KW  - Violales
KW  - Ocimum
KW  - Lamiaceae
KW  - Lamiales
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - bacterium
KW  - mammary tumour
KW  - neem
KW  - vegetable crops
KW  - Crop Produce (QQ050) 
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417613&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV: from molecular recognition to tissue pathogenesis.
AU  - Margolis, L.
JO  - FEBS Letters
JF  - FEBS Letters
Y1  - 1998///
VL  - 433
IS  - 1/2
SP  - 5
EP  - 8
SN  - 0014-5793
AD  - Margolis, L.: Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10D14, Bethesda, MD 20892, USA.
N1  - Accession Number: 19982013208.  Publication Type: Journal Article.  Language: English.  Number of References: 52 ref.
N2  - Dramatic progress has been made recently in identifying both viral and cellular molecules responsible for binding and fusion of HIV-1 to target cells. In vivo, HIV-1 infection is transmitted by viruses that recognize chemokine receptor CCR5, while viruses isolated at later stages of HIV disease often recognize another chemokine receptor, CXCR4. It is still not understood how this molecular tropism of HIV-1 is translated into the virus' ability to compromise normal cell functions, which results in impairment of lymphoid tissue and causes AIDS. Here, how the new molecular findings might relate to HIV pathogenesis in cells and tissues are discussed.
KW  - acquired immune deficiency syndrome
KW  - binding sites
KW  - chemokines
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pathogenesis
KW  - receptors
KW  - reviews
KW  - viral diseases
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - binding site
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013208&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - First National AIDS Malignancy Conference.
AU  - Feigal, E.\Beral, V.\Kieff, E.\Palefsky, J. M.\Marco, M.\Rabkin, C. S.\Lowy, D. R.\Mueller, B. U.\Levine, A. M.\Maiman, M.\Weiss, R. A.\Gallo, R. C.\Krown, S. E.\Moore, P. S.\Neipel, F.\Nicholas, J.\Rooney, C. M.\Gaidano, G.\Kaplan, L. D.
T2  - Journal of the National Cancer Institute Monographs
JO  - Journal of the National Cancer Institute Monographs
JF  - Journal of the National Cancer Institute Monographs
Y1  - 1998///
IS  - 23
SP  - 105 + iv
EP  - 105 + iv
AD  - USA, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19982007903.  Publication Type: Conference proceedings.  Language: English. 
N2  - This issue is devoted to the proceedings of a conference held at the National Institutes of Health, Bethesda, Maryland, USA, 28-30 April, 1997. Contributions by many authors cover epidemiology of immunodeficiency-associated cancers; molecular pathogenesis of virus-induced cancers in HIV infection and AIDS; human papillomavirus infection and anogenital neoplasia in HIV disease; the community perspective of AIDS-related cancers; association of non-AIDS defining cancers with HIV infection; papillomaviruses and cervical cancer: pathogenesis and vaccine development; cancers in HIV-infected children; Hodgkin's disease in HIV infection; management of cervical neoplasia in HIV-infected women; Kaposi's sarcoma: association with humanherpesvirus 8, pathogenesis, therapeutics, KS-associated oncogenes and oncogenesis; immunotherapy for Epstein-Barr virus-associated cancers; genetic basis of AIDS-related lymphomagenesis; and clinical management of HIV-associated non-Hodgkin's lymphoma.
KW  - acquired immune deficiency syndrome
KW  - children
KW  - epidemiology
KW  - human diseases
KW  - Kaposi's sarcoma
KW  - lymphoma
KW  - malignant course
KW  - neoplasms
KW  - pathogenesis
KW  - treatment
KW  - Herpesviridae
KW  - Human herpesvirus 4
KW  - human herpesvirus 8
KW  - human papillomaviruses
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - Rhadinovirus
KW  - Papillomavirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - Papillomaviridae
KW  - AIDS
KW  - cancers
KW  - Epstein-Barr virus
KW  - human papillomavirus
KW  - Kaposi's sarcoma-associated herpesvirus
KW  - Papovaviridae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007903&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The role of free radical mediation of protein oxidation in aging and disease.
AU  - Stadtman, E. R.
A2  - Özben, T.
T2  - Free radicals, oxidative stress, and antioxidants: pathological and physiological significance. Proceedings of a NATO Advanced Study Institute, Antalya, Turkey, 24 May-4 June, 1997.
JO  - Free radicals, oxidative stress, and antioxidants: pathological and physiological significance. Proceedings of a NATO Advanced Study Institute, Antalya, Turkey, 24 May-4 June, 1997.
JF  - Free radicals, oxidative stress, and antioxidants: pathological and physiological significance. Proceedings of a NATO Advanced Study Institute, Antalya, Turkey, 24 May-4 June, 1997.
Y1  - 1998///
SP  - 131
EP  - 143
CY  - New York; USA
PB  - Plenum Publishing Corporation
SN  - 0306458136
AD  - Stadtman, E. R.: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Room 222, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19991416045.  Publication Type: Conference paper.  Language: English.  Number of References: 5 pp of ref. Subject Subsets: Human Nutrition
N2  - A review.
KW  - aging
KW  - diseases
KW  - free radicals
KW  - oxidation
KW  - protein
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991416045&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Docosahexaenoic acid-containing phospholipids optimally promote rhodopsin activation.
AU  - Mitchell, D. C.
AU  - Litman, B. J.
A2  - Riemersma, R. A.
A2  - Armstrong, R.
A2  - Kelly, R. W.
A2  - Wilson, R.
T2  - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997.
JO  - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997.
JF  - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997.
Y1  - 1998///
SP  - 154
EP  - 158
CY  - Champaign; USA
PB  - AOCS Press
SN  - 0935315969
AD  - Mitchell, D. C.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
N1  - Accession Number: 19991403965.  Publication Type: Conference paper.  Language: English.  Number of References: 19 ref. Registry Number: 25167-62-8, 9009-81-8.  Subject Subsets: Human Nutrition
KW  - docosahexaenoic acid
KW  - essential fatty acids
KW  - phospholipids
KW  - polyenoic fatty acids
KW  - rhodopsin
KW  - visual pigments
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - polyunsaturated fatty acids
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403965&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Alcoholism, antioxidant status, and essential fatty acids.
AU  - Lands, W. E. M.
AU  - Pawlosky, R. J.
A2  - Papas, A. M.
T2  - Antioxidant status, diet, nutrition, and health.
JO  - Antioxidant status, diet, nutrition, and health.
JF  - Antioxidant status, diet, nutrition, and health.
Y1  - 1998///
SP  - 299
EP  - 344
CY  - Bethesda; USA
PB  - American Fisheries Society
SN  - 184938009X
AD  - Lands, W. E. M.: NIAAA, National Institutes of Health, 6000 Executive Blvd., Wilco Building, Room 400, Bethesda, MD 20892-7003, USA.
N1  - Accession Number: 19991403637.  Publication Type: Miscellaneous.  Language: English.  Number of References: 303 ref. Registry Number: 64-17-5, 70-18-8, 68-26-8, 7782-49-2, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - This chapter describes the effects of alcohol abuse on cellular antioxidant status and on the essential fatty acids and nutrients that antioxidants help to preserve.
KW  - alcoholism
KW  - enzymes
KW  - ethanol
KW  - glutathione
KW  - lipid peroxidation
KW  - lipids
KW  - minerals
KW  - nutritional state
KW  - polyenoic fatty acids
KW  - retinol
KW  - selenium
KW  - trace elements
KW  - vitamin E
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - ethyl alcohol
KW  - lipins
KW  - microelements
KW  - nutritional status
KW  - polyunsaturated fatty acids
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - The phospholipid bilayer mediates the effect of primary alcohols on rhodopsin activation.
AU  - Mitchell, D. C.
AU  - Litman, B. J.
A2  - Riemersma, R. A.
A2  - Armstrong, R.
A2  - Kelly, R. W.
A2  - Wilson, R.
T2  - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997.
JO  - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997.
JF  - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997.
Y1  - 1998///
SP  - 336
EP  - 340
CY  - Champaign; USA
PB  - AOCS Press
SN  - 0935315969
AD  - Mitchell, D. C.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
N1  - Accession Number: 19991404047.  Publication Type: Conference paper.  Language: English.  Number of References: 29 ref. Registry Number: 64-17-5, 9009-81-8.  Subject Subsets: Human Nutrition
KW  - alcoholic beverages
KW  - alcoholism
KW  - alcohols
KW  - cell cultures
KW  - ethanol
KW  - membranes
KW  - phospholipids
KW  - rhodopsin
KW  - ethyl alcohol
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404047&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antioxidants and cancer: evidence from human studies and intervention trials.
AU  - Albanes, D.
AU  - Hartman, T. J.
A2  - Papas, A. M.
T2  - Antioxidant status, diet, nutrition, and health.
Y1  - 1998///
CY  - Bethesda; USA
PB  - American Fisheries Society
SN  - 184938009X
AD  - Albanes, D.: Division of Clinical Sciences, National Cancer Institute, 6006 Executive Blvd., Room 321, National Institutes of Health, Bethesda, MD 20892-7058, USA.
N1  - Accession Number: 19991403629.  Publication Type: Book chapter.  Language: English.  Number of References: 385 ref. Registry Number: 50-81-7, 7235-40-7, 7439-98-7, 7782-49-2, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - The relationship between cancer and antioxidants is explored under the following headings: Antioxidants and carcinogenesis; β-Carotene and other carotenoids-observational epidemiological studies, randomized intervention trials; Vitamin C; Vitamin E; Selenium.
KW  - antioxidants
KW  - ascorbic acid
KW  - beta-carotene
KW  - carotenoids
KW  - diet
KW  - minerals
KW  - molybdenum
KW  - neoplasms
KW  - selenium
KW  - vitamin E
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - Mo
KW  - tetraterpenoids
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403629&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Vitamin C.
AU  - Rumsey, S. C.
AU  - Wang, Y.
AU  - Levine, M.
A2  - Papas, A. M.
T2  - Antioxidant status, diet, nutrition, and health.
Y1  - 1998///
CY  - Bethesda; USA
PB  - American Fisheries Society
SN  - 184938009X
AD  - Rumsey, S. C.: Laboratory of Cell Biology and Kinetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20852, USA.
N1  - Accession Number: 19991403616.  Publication Type: Book chapter.  Language: English.  Number of References: 160 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - This chapter provides an overview of the current data concerning vitamin C. Areas of focus include: Biochemistry-chemical reactions, enzymatic reactions; pharmacokinetics-intake and bioavailability, plasma concentrations, cellular distribution; and In situ kinetics and recommended intake.
KW  - ascorbic acid
KW  - availability
KW  - blood
KW  - enzymes
KW  - guidelines
KW  - intake
KW  - kinetics
KW  - vitamins
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - recommendations
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Diagnosis of invasive fungal infections in transplant recipients.
AU  - Walsh, T. J.
AU  - Chanock, S. J.
A2  - Bowden, R. A.
A2  - Ljungman, P.
A2  - Paya, C. V.
T2  - Transplant infections.
Y1  - 1998///
CY  - Hagerstown; USA
PB  - Lippincott-Raven Publishers
SN  - 0397587767
AD  - Walsh, T. J.: Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 90892, USA.
N1  - Accession Number: 19991201745.  Publication Type: Book chapter.  Language: English.  Number of References: 259 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The diagnosis of invasive infections due to yeasts and filamentous fungi in transplant recipients is reviewed. The clinical manifestations of candidosis and aspergillosis, direct examination and culture of Candida spp. and Aspergillus spp., the significance and detection of fungaemia, serological methods to detect candidosis and aspergillosis, amplification of Candida and Aspergillus DNA by polymerase chain reaction, and antifungal susceptibility testing of yeasts, are discussed. Infections due to Cryptococcus neoformans, Trichosporon, Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis and Penicillium marneffei, Fusarium, Pseudallescheria boydii and agents of zygomycosis, are also considered.
KW  - aspergillosis
KW  - blastomycosis
KW  - candidosis
KW  - coccidioidomycosis
KW  - cryptococcosis
KW  - diagnosis
KW  - fusariosis
KW  - histoplasmosis
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - opportunistic infections
KW  - reviews
KW  - transplant recipients
KW  - transplantation
KW  - zygomycosis
KW  - Aspergillus
KW  - Blastomyces dermatitidis
KW  - Candida
KW  - Coccidioides immitis
KW  - Cryptococcus neoformans
KW  - Fusarium
KW  - Histoplasma capsulatum
KW  - man
KW  - Penicillium marneffei
KW  - Pseudallescheria boydii
KW  - Trichosporon
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Blastomyces
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Coccidioides
KW  - Onygenaceae
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Histoplasma
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Penicillium
KW  - Pseudallescheria
KW  - Microascaceae
KW  - Microascales
KW  - Trichosporonaceae
KW  - Ajellomyces capsulatus
KW  - candidiasis
KW  - coccidiomycosis
KW  - european blastomycosis
KW  - fungus
KW  - fusarioses
KW  - Hyphomycetes
KW  - phycomycosis
KW  - recipients
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology.
AU  - Wynn, T. A.
JO  - Microbes and Infection
JF  - Microbes and Infection
Y1  - 1999///
VL  - 1
IS  - 7
SP  - 525
EP  - 534
AD  - Wynn, T. A.: The Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990805771.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Registry Number: 130068-27-8, 207137-56-2, 148157-34-0.  Subject Subsets: Helminthology
N2  - This review covers: the pulmonary granuloma model (evidence of a primary role for Th2-associated cytokines in egg-induced granuloma formation); IL-4 and IL-10 are both essential to the development of a polarized egg-specific Th2-type cytokine response; pulmonary egg-induced granuloma formation is mediated by the dual effects of IL-4 and IL-13; characterization of an IL-12-based vaccination strategy that reduces egg-induced pathology and Th2-type cytokine expression; the irradiated cercariae model (characterization of the resistance mechanisms in singly and multiply immunized mice); evidence of a mixed Th1/Th2-type response in the lungs and lymph nodes of vaccinated and challenged mice; IL-12 enhances immunity induced by the irradiated cercariae vaccine by boosting type-1-associated humoral and cell-mediated immune responses.
KW  - cytokines
KW  - helminths
KW  - immune response
KW  - immunization
KW  - immunopathology
KW  - interleukin 10
KW  - interleukin 12
KW  - interleukin 13
KW  - interleukin 4
KW  - parasites
KW  - reviews
KW  - schistosomiasis
KW  - T lymphocytes
KW  - vaccines
KW  - Schistosoma mansoni
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - bilharzia
KW  - bilharziasis
KW  - granulomata
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - parasitic worms
KW  - schistosomosis
KW  - Strigeida
KW  - T cells
KW  - T helper cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relative validity of a food frequency questionnaire among tin miners in China: 1992/93 and 1995/96 diet validation studies.
AU  - Forman, M. R.
AU  - Zhang, J.
AU  - Nebeling, L.
AU  - Yao, S. X.
AU  - Slesinski, M. J.
AU  - Qiao, Y. L.
AU  - Ross, S.
AU  - Keith, S.
AU  - Maher, M.
AU  - Giffin, C.
AU  - Barrett, M.
AU  - Taylor, P. R.
AU  - Graubard, B. I.
JO  - Public Health Nutrition
JF  - Public Health Nutrition
Y1  - 1999///
VL  - 2
IS  - 3
SP  - 301
EP  - 315
AD  - Forman, M. R.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-7326, USA.
N1  - Accession Number: 19991414296.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - Diet validation research was conducted to compare reporting of dietary intake in a food frequency questionnaire (FFQ) with intake reported in food recalls. Because the population received annual salary increments that could modify food intake, diet validation studies (DVS) were conducted during 2 time intervals. A 99-item FFQ was administered by an interviewer twice in 1-year, and responses to each FFQ item were compared with 28 days of interviewer-administered food recalls that were collected in four 1-week intervals during each season of 1992/93. The second validation study in 1995/96 had a similar design. Among a cohort of high risk tin miners for lung cancer, 2 different samples (n=141 in 1992/93, and n=113 in 1995/96) for each DVS were randomly selected from 4 representative mine units. Miners reported a significantly higher average frequency of intake of foods in the food recalls than the FFQ. Deattenuated Pearson correlation coefficients of the frequency of food intake between the FFQ and food recalls were in the range of -0.40 to 0.72 in both studies, with higher positive correlations for beverages and cereal staples than for animal protein sources, vegetables, fruits and legumes. The percentage of individuals with exact agreement in the extreme quartiles of intake in the food recalls and FFQ ranged from 0 to 100%. Among Chinese miners, the range in correlations between the food recalls and the FFQ were due to; market availability of foods during the food recall weeks compared to their annual reported intake in the FFQ, cultural perception of time and differences in how the intake of mixed dishes and their multi-ingredient foods were reported in the recalls vs. the FFQ. The range in the percentage of agreement in the same quartiles and the changes in food intake over time may have implications for the analysis of the diet-disease relationship in this cohort.
KW  - diet studies
KW  - diet study techniques
KW  - food intake
KW  - intake
KW  - legumes
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - protein sources
KW  - questionnaires
KW  - risk factors
KW  - vegetables
KW  - China
KW  - Fabaceae
KW  - man
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancers
KW  - People's Republic of China
KW  - vegetable crops
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414296&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genome projects, genetic analysis, and the changing landscape of malaria research.
AU  - Wellems, T. E.
AU  - Su XinZhuan
AU  - Ferdig, M.
AU  - Fidock, D. A.
A2  - Cormack, B.
A2  - Rouse, B. T.
A2  - Beverley, S. M.
JO  - Current Opinion in Microbiology
JF  - Current Opinion in Microbiology
Y1  - 1999///
VL  - 2
IS  - 4
SP  - 415
EP  - 419
AD  - Wellems, T. E.: Malaria Genetics Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 4 Center Drive, MSC 0425, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000805451.  Publication Type: Journal Article.  Language: English.  Number of References: 58 ref. Subject Subsets: Protozoology
N2  - This review discusses recent research on the molecular genetics of Plasmodium falciparum. The main sections cover: genetic analysis and linkage maps; chromosome maps and sequencing projects; the use of the large amounts of data now available to achieve advances against the disease; and Internet resources and information exchange. It is concluded that deciphering the P. falciparum genome will require understanding at multiple levels of an integrated system, and will transform malaria research in unexpected ways.
KW  - diffusion of information
KW  - DNA sequencing
KW  - genetic analysis
KW  - genome analysis
KW  - human diseases
KW  - internet
KW  - malaria
KW  - molecular genetics
KW  - parasites
KW  - research
KW  - reviews
KW  - man
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - biochemical genetics
KW  - information dissemination
KW  - nucleotide sequence analysis
KW  - nucleotide sequencing
KW  - studies
KW  - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW  - Information and Documentation (CC300) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses.
AU  - McDowell, M. A.
AU  - Sacks, D. L.
A2  - Cormack, B.
A2  - Rouse, B. T.
A2  - Beverley, S. M.
JO  - Current Opinion in Microbiology
JF  - Current Opinion in Microbiology
Y1  - 1999///
VL  - 2
IS  - 4
SP  - 438
EP  - 443
AD  - McDowell, M. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
N1  - Accession Number: 20000805547.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Subject Subsets: Protozoology
N2  - This review summarizes findings relevant to the selective impairment of interleukin 12 induction pathways in Leishmania-infected macrophages, in particular the disruption of host cell signal transduction networks.
KW  - host parasite relationships
KW  - immune response
KW  - immunological deficiency
KW  - interleukin 12
KW  - leishmaniasis
KW  - macrophages
KW  - parasites
KW  - reviews
KW  - signal transduction
KW  - Leishmania
KW  - protozoa
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - immune deficiency
KW  - immunity reactions
KW  - immunodeficiency
KW  - immunological reactions
KW  - leishmaniosis
KW  - parasite host relationships
KW  - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW  - Human Immunology and Allergology (VV055) (New March 2000)
KW  - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000805547&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies. Commentary.
AU  - Priola, S. A.
AU  - Caughey, B.
AU  - Caughey, W. S.
JO  - Current Opinion in Microbiology
JF  - Current Opinion in Microbiology
Y1  - 1999///
VL  - 2
IS  - 5
SP  - 563
EP  - 566
AD  - Priola, S. A.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 20002212452.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Veterinary Science
KW  - bovine spongiform encephalopathy
KW  - Creutzfeldt-Jakob disease
KW  - porphyrins
KW  - prion diseases
KW  - spongiform encephalopathy
KW  - bovine encephalopathy
KW  - BSE
KW  - mad cow disease
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002212452&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Nutritional modulation of aging in nonhuman primates.
AU  - Lane, M. A.
AU  - Ingram, D. K.
AU  - Roth, G. S.
JO  - Journal of Nutrition, Health & Aging
JF  - Journal of Nutrition, Health & Aging
Y1  - 1999///
VL  - 3
IS  - 2
SP  - 69
EP  - 76
AD  - Lane, M. A.: Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
N1  - Accession Number: 19991413854.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Human Nutrition
N2  - This review summarizes the major findings of studies of energy restriction in primates and its effect on lifespan and the development of age-related diseases. It is concluded that the physiological responses to energy restriction in monkeys parallel the extensive findings reported in rodents.
KW  - aging
KW  - energy
KW  - energy deprivation
KW  - longevity
KW  - old age
KW  - reviews
KW  - man
KW  - monkeys
KW  - Primates
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ageing
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413854&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction.
AU  - Kari, F. W.
AU  - Dunn, S. E.
AU  - French, J. E.
AU  - Barrett, J. C.
JO  - Journal of Nutrition, Health & Aging
JF  - Journal of Nutrition, Health & Aging
Y1  - 1999///
VL  - 3
IS  - 2
SP  - 92
EP  - 101
AD  - Kari, F. W.: Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19991413857.  Publication Type: Journal Article.  Language: English.  Number of References: 95 ref. Registry Number: 61912-98-9.  Subject Subsets: Human Nutrition
N2  - This paper reviews the role of insulin-like growth factor-1 (IGF-1) and its associated regulatory apparatus as a key endocrine, autocrine and paracrine signalling system involved in mediating the anticarcinogenic activity of dietary restriction. It is concluded that epidemiological observations and clinical oncology results support the involvement of IGF-1 in carcinogenesis and anticarcinogenesis, leading to the hypothesis that factors such as IGF-1 which regulate body size and composition may be related to cancer incidence or prognosis in man.
KW  - carcinogenesis
KW  - energy deprivation
KW  - insulin-like growth factor
KW  - neoplasms
KW  - reviews
KW  - cancers
KW  - somatomedin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413857&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic strategies to inhibit HIV.
AU  - Morgan, R. A.
JO  - Molecular Medicine Today
JF  - Molecular Medicine Today
Y1  - 1999///
VL  - 5
IS  - 10
SP  - 454
EP  - 458
AD  - Morgan, R. A.: Gene Transfer Technology Section, Clinical Gene Therapy Branch/National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1851, USA.
N1  - Accession Number: 20002006957.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
N2  - The worldwide incidence of HIV infection continues to rise despite more than a decade of intense research aimed at developing effective intervention strategies. Because the mechanisms of action of the essential HIV gene products are now known, these have become potential targets for intervention. Some of these targets are attractive candidates for intervention by gene therapy. This review focuses on the recent progress in gene therapy strategies, including approaches approved for clinical trials. The efficacy of these various anti-HIV strategies, as well as the advantages and drawbacks of the different existing gene delivery systems, is discussed.
KW  - gene therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Other Control Measures (HH700) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006957&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease.
AU  - Hemmer, B.
AU  - Gran, B.
AU  - Zhao YingDong
AU  - Marques, A.
AU  - Pascal, J.
AU  - Tzou, A.
AU  - Kondo, T.
AU  - Cortese, I.
AU  - Bielekova, B.
AU  - Straus, S. E.
AU  - McFarland, H. F.
AU  - Houghten, R.
AU  - Simon, R.
AU  - Pinilla, C.
AU  - Martin, R.
JO  - Nature Medicine
JF  - Nature Medicine
Y1  - 1999///
VL  - 5
IS  - 12
SP  - 1375
EP  - 1382
AD  - Hemmer, B.: Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5B-16, 10 Center DR MSC 1400, Bethesda, MD 20892-1400, USA.
N1  - Accession Number: 20000505586.  Publication Type: Journal Article.  Language: English.  Number of References: 56 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A new method of effectively identifying both microbial epitopes and candidate autoantigens in Lyme disease is described. The approach combines data acquisition by positional scanning peptide combinatorial libraries and biometric data analysis by generation of scoring matrices. In a 35-year-old male who presented in 1993 in Wisconsin with chronic neuroborreliosis, this strategy led to the identification of potentially relevant T-cell targets derived from both Borrelia burgdorferi and the host. The antigen specificity of a single T-cell clone could be degenerate and yet the clone could preferentially recognize different peptides derived from the same organism, thus demonstrating that flexibility in T-cell recognition does not preclude specificity.
KW  - amino acid sequences
KW  - antigens
KW  - autoimmunity
KW  - clones
KW  - epitopes
KW  - human diseases
KW  - Lyme disease
KW  - molecular genetics
KW  - peptides
KW  - T lymphocytes
KW  - USA
KW  - Wisconsin
KW  - Borrelia burgdorferi
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - East North Central States of USA
KW  - North Central States of USA
KW  - USA
KW  - Lake States of USA
KW  - antigenic determinants
KW  - antigenicity
KW  - bacterium
KW  - biochemical genetics
KW  - immunogens
KW  - lyme borreliosis
KW  - protein sequences
KW  - T cells
KW  - United States of America
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000505586&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Development and testing of Streptococcus pneumoniae conjugate vaccines.
AU  - Klein, D. L.
AU  - Eskola, J.
A2  - Tomasz, A.
A2  - Carbon, C.
JO  - Clinical Microbiology and Infection
JF  - Clinical Microbiology and Infection
Y1  - 1999///
VL  - 5
IS  - Suppl. 4
SP  - 4S17
EP  - 4S28
AD  - Klein, D. L.: National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
N1  - Accession Number: 20002004541.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 51 ref. Subject Subsets: Public Health
N2  - This paper on pneumococcal conjugate vaccines reviews clinical data that have contributed to the characterization of conjugate vaccines, recent vaccine trials that define efficacy, and alternative pneumococcal vaccine strategies. Tables outline basic and clinical issues and questions that remain to be addressed, and a summary of what is currently known and can be said about pneumococcal conjugate vaccines is provided.
KW  - conjugate vaccines
KW  - human diseases
KW  - reviews
KW  - vaccine development
KW  - vaccines
KW  - man
KW  - Streptococcus
KW  - Streptococcus pneumoniae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Streptococcaceae
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Streptococcus
KW  - bacterium
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004541&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of common lipooligosaccharide types in isolates from patients with otitis media by monoclonal antibodies against nontypeable Haemophilus influenzae 9274.
AU  - Ueyama, T.
AU  - Gu XinXing
AU  - Tsai ChaoMing
AU  - Karpas, A. B.
AU  - Lim, D. J.
JO  - Clinical and Diagnostic Laboratory Immunology
JF  - Clinical and Diagnostic Laboratory Immunology
Y1  - 1999///
VL  - 6
IS  - 1
SP  - 96
EP  - 100
SN  - 1071-412X
AD  - Ueyama, T.: Laboratory of Immunology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, USA.
N1  - Accession Number: 19992005022.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref.
N2  - A total of 21 murine monoclonal antibodies (MAbs) were induced by nontypeable H. influenzae (NTHi) 9274. 19 MAbs were specific for the lipooligosaccharide (LOS) as determined by ELISA and Western blot analysis. When the MAbs were assayed with 5 LOS prototype strains by ELISA, all bound to strain 3198 LOS (type III), while 6 of the MAbs were also reactive with LOSs from strain 1479 (type I), 5657 (type IV) or 7502 (type V). Ten MAbs had complement-mediated bactericidal activity and 3 MAbs were opsonophagocytic against the homologous strain. Five LOS MAbs with different specificities were used to analyse 155 NTHi clinical isolates from the USA and Japan. These isolates were classified into 9 groups by ELISA. Only 4 isolates (2.6%) were not recognized by any of the 5 MAbs. Most of the isolates (91.6%) were in 4 groups which bound 3 of the 5 MAbs. One of 3 MAbs, 6347C11, had strong activity against the homologous strain and was also bactericidal to 45 clinical isolates (29%) which belonged to the 4 common patterns (25 belonged to pattern 1). It is suggested that these MAbs can be used for LOS typing in which almost all NTHi strains can be typed according to the LOS antigenicity. Among NTHi, at least one conserved LOS epitope which is a target of bactericidal antibodies exists. It is concluded that strain 9274 LOS, which is the target for bactericidal antibodies, is a candidate for LOS-based NTHi vaccines.
KW  - children
KW  - epitopes
KW  - human diseases
KW  - monoclonal antibodies
KW  - otitis media
KW  - Japan
KW  - USA
KW  - Haemophilus influenzae
KW  - man
KW  - Haemophilus
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - North America
KW  - America
KW  - antigenic determinants
KW  - bacterium
KW  - glue ear
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human uncoupling proteins and obesity.
AU  - Schrauwen, P.
AU  - Walder, K.
AU  - Ravussin, E.
JO  - Obesity Research
JF  - Obesity Research
Y1  - 1999///
VL  - 7
IS  - 1
SP  - 97
EP  - 105
AD  - Schrauwen, P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix AZ 85016, USA.
N1  - Accession Number: 20001407427.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Registry Number: 56-65-5.  Subject Subsets: Human Nutrition
N2  - The headings of this review are: ATP consuming processes; non-ATP consuming processes; role of brown adipose tissue in energy metabolism; a novel UCP, UCP2; UCP in skeletal muscle, UCP3; role of UCP2 and UCP3 in obesity and energy expenditure; and regulation of UCP2 and UCP3 gene expression.
KW  - adipose tissue
KW  - ATP
KW  - brown fat
KW  - energy metabolism
KW  - gene expression
KW  - obesity
KW  - reviews
KW  - skeletal muscle
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adenosine triphosphate
KW  - fatness
KW  - uncoupling protein
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001407427&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of taxol on the expression of transforming growth factor beta-1 in Ehrlich ascites carcinoma cells.
AU  - Saad, S. Y.
AU  - Ali, M.
JO  - Saudi Pharmaceutical Journal
JF  - Saudi Pharmaceutical Journal
Y1  - 1999///
VL  - 7
IS  - 4
SP  - 201
EP  - 204
SN  - 1319-0164
AD  - Saad, S. Y.: Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
N1  - Accession Number: 20000310183.  Publication Type: Journal Article.  Language: English.  Language of Summary: Arabic.  Number of References: 15 ref. Registry Number: 33069-62-4.  Subject Subsets: Horticultural Science
N2  - Ehrlich ascites carcinoma cells (EAC) were relatively sensitive to taxol (from Taxus) and exhibited a significant apoptotic response following treatment in vitro. The effect of taxol treatment on the expression of transforming growth factor beta one (TGF-β1) in vitro was examined. EAC cell line (6×106 cell) were exposed to different concentrations of taxol for different intervals of time, and the amount of intracellular TGF-β1 was measured using ELISA technique and Western blotting. Results revealed that 50 nM of taxol is the optimum concentration at which TGF-β1 was expressed. Also TGF-β1 expression was maximum after 24 h of exposure to taxol rather than the other exposure times (2, 4 or 6 h). The mechanism of tumour responsiveness to taxol associated with increased expression of TGF-β1 is discussed.
KW  - cell lines
KW  - chemical composition
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - ELISA
KW  - growth factors
KW  - in vitro
KW  - medicinal plants
KW  - paclitaxel
KW  - plant composition
KW  - Taxus
KW  - Taxaceae
KW  - Taxopsida
KW  - gymnosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - chemical constituents of plants
KW  - drug plants
KW  - enzyme linked immunosorbent assay
KW  - medicinal herbs
KW  - officinal plants
KW  - taxol
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Non-wood Forest Products (KK540) 
KW  - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000310183&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fasting and postprandial plasma concentrations of acylation-stimulation protein (ASP) in lean and obese Pima Indians compared to Caucasians.
AU  - Weyer, C.
AU  - Pratley, R. E.
JO  - Obesity Research
JF  - Obesity Research
Y1  - 1999///
VL  - 7
IS  - 5
SP  - 444
EP  - 452
AD  - Weyer, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 20001411497.  Publication Type: Journal Article.  Language: English.  Number of References: 47 ref. Registry Number: 57-88-5, 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Plasma concentrations of acylation-stimulation protein (ASP), triglycerides (TG), free fatty acids (FFA), total cholesterol (CHOL), and insulin (INS) were measured in 15 Pima Indians (P) and 15 Caucasians (C) closely matched for age, sex, and body weight (7 lean and 8 obese subjects, body mass index (BMI) cut-off = 30), before and for 4 h after a standard mixed meal (20% of daily energy requirements, 41% carbohydrate, 44% fat, 15% protein). Fasting ASP was positively related to percent body fat (dual energy X-ray absorptiometry; r=0.49, p&lt;0.01) and to TG and FFA, independently of percent body fat (partial r=0.42 and 0.46, respectively, both p&lt;0.05). There were no differences in fasting TG, FFA, CHOL, INS, or ASP between lean C and lean P. In contrast, obese P had lower TG, lower CHOL, higher INS and, on average, 27% lower ASP compared to obese C. The ethnic difference in ASP remained after adjustment for TG, FFA, and percent body fat. ASP decreased in response to the meal in all 4 groups with no differences between groups. There was a significant inverse correlation between preprandial ASP and the change in FFA 60 min after the meal (r=0.56, p&lt;0.001). Pima Indians do not have higher plasma ASP concentrations than Caucasians. Whether other alterations in the ASP-pathway, such as increased sensitivity of adipocytes to ASP, contribute to the high prevalence of obesity and low prevalence of dyslipidaemia in Pima Indians, remains to be elucidated.
KW  - anthropometric dimensions
KW  - blood chemistry
KW  - blood lipids
KW  - body fat
KW  - cholesterol
KW  - energy intake
KW  - ethnic groups
KW  - fatty acids
KW  - insulin
KW  - lipaemia
KW  - obesity
KW  - protein
KW  - triacylglycerols
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - acylation stimulation protein
KW  - anthropometric measurements
KW  - fatness
KW  - lipemia
KW  - triglycerides
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Quasispecies in viral persistence and pathogenesis of hepatitis C virus.
AU  - Forns, X.
AU  - Purcell, R. H.
AU  - Bukh, J.
JO  - Trends in Microbiology
JF  - Trends in Microbiology
Y1  - 1999///
VL  - 7
IS  - 10
SP  - 402
EP  - 409
CY  - Oxford; UK
PB  - Elsevier Science Ltd
SN  - 0966-842X
AD  - Forns, X.: Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20033098168.  Publication Type: Journal Article.  Language: English.  Number of References: 73 ref. Subject Subsets: Public Health
N2  - Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. This RNA virus circulates as a quasispecies and its genetic heterogeneity has been implicated in the lack of protective immunity against HCV and in its persistence following infection. HCV might escape from immune surveillance by developing mutations in proteins that are subject to immune pressure.
KW  - chronic infections
KW  - genetic variation
KW  - hepatitis C
KW  - human diseases
KW  - molecular biology
KW  - molecular genetics
KW  - mutations
KW  - pathogenesis
KW  - reviews
KW  - hepatitis C virus
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - biochemical genetics
KW  - genetic variability
KW  - genotypic variability
KW  - genotypic variation
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033098168&site=ehost-live&scope=site
UR  - email: jbukh@niaid.nih.gov
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Role of dietary fat in the causation of breast cancer: point.
AU  - Greenwald, P.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1999///
VL  - 8
IS  - 1
SP  - 3
EP  - 7
SN  - 1055-9965
AD  - Greenwald, P.: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19991412653.  Publication Type: Journal Article.  Language: English.  Number of References: 65 ref. Subject Subsets: Human Nutrition
N2  - A review.
KW  - diet
KW  - fat
KW  - mammary gland neoplasms
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - mammary tumour
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary factors and risks for prostate cancer among blacks and whites in the United States.
AU  - Hayes, R. B.
AU  - Ziegler, R. G.
AU  - Gridley, G.
AU  - Swanson, C.
AU  - Greenberg, R. S.
AU  - Swanson, G. M.
AU  - Schoenberg, J. B.
AU  - Silverman, D. T.
AU  - Brown, L. M.
AU  - Pottern, L. M.
AU  - Liff, J.
AU  - Schwartz, A. G.
AU  - Fraumeni, J. F., Jr.
AU  - Hoover, R. N.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1999///
VL  - 8
IS  - 1
SP  - 25
EP  - 34
SN  - 1055-9965
AD  - Hayes, R. B.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19991412652.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 7440-70-2, 68-26-8.  Subject Subsets: Human Nutrition
N2  - Prostate cancer is the most common malignancy in men in the USA, with substantially higher rates among American blacks than whites. A population-based case-control study was undertaken in three geographic areas of the USA to evaluate the reasons for the racial disparity in incidence rates. A total of 932 men (449 black men and 483 white men) who had been newly diagnosed with pathologically confirmed prostate cancer and 1201 controls (543 black men and 658 white men) were interviewed in person to elicit information on potential risk factors. This report evaluates the impact of dietary factors, particularly the consumption of animal products and animal fat, on the risk of prostate cancer among blacks and whites in the USA. Increased consumption (g/day) of foods high in animal fat was linked to prostate cancer (independent of intake of other calories) among American blacks [by quartile of intake, odds ratio (OR) =1.0 (referent), 1.5, 2.1, and 2.0; Ptrend = 0.007], but not among American whites [by quartile of intake, OR = 1.0 (referent), 1.6, 1.5, and 1.1; Ptrend = 0.90]. However, risks for advanced prostate cancer were higher with greater intake of foods high in animal fat among blacks [by quartile of intake, OR = 1.0 (referent), 2.2, 4.2, and 3.1; Ptrend = 0.006] and whites [by quartile of intake, OR = 1.0 (referent), 2.2, 2.6, and 2.4; Ptrend = 0.02]. Increased intake of animal fat as a proportion of total caloric intake also showed positive but weaker associations with advanced prostate cancer among blacks (Ptrend = 0.13) and whites (Ptrend = 0.08). No clear associations were found with vitamin A, calcium, or specific lycopene-rich foods. The study linked greater consumption of fat from animal sources to increased risk for prostate cancer among American blacks and to advanced prostate cancer among American blacks and whites.
KW  - animal fat
KW  - animal products
KW  - calcium
KW  - diet
KW  - ethnic groups
KW  - fat
KW  - neoplasms
KW  - prostate
KW  - retinol
KW  - risk
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - cancers
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991412652&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The anti-carcinogenic role of lycopene, abundantly present in tomato.
AU  - Sengupta, A.
AU  - Das, S.
JO  - European Journal of Cancer Prevention
JF  - European Journal of Cancer Prevention
Y1  - 1999///
VL  - 8
IS  - 4
SP  - 325
EP  - 330
SN  - 0959-8278
AD  - Sengupta, A.: Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37 S P. Mukherjee Road, Calcutta 700026, India.
N1  - Accession Number: 19991414227.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 502-65-8.  Subject Subsets: Human Nutrition
KW  - antineoplastic agents
KW  - antioxidants
KW  - blood chemistry
KW  - breast cancer
KW  - carotenoids
KW  - composition
KW  - fruit vegetables
KW  - lycopene
KW  - neoplasms
KW  - pancreatic cancer
KW  - prevention
KW  - prostate cancer
KW  - tomatoes
KW  - vitamins
KW  - Solanum
KW  - Solanum lycopersicum
KW  - Solanum
KW  - Solanaceae
KW  - Solanales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - cancers
KW  - cytotoxic agents
KW  - Lycopersicon
KW  - Lycopersicon esculentum
KW  - metaanalysis
KW  - tetraterpenoids
KW  - Crop Produce (QQ050) 
KW  - Food Composition and Quality (QQ500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of α-tocopherol and β-carotene supplementation on colorectal adenomas in middle-aged male smokers.
AU  - Malila, N.
AU  - Virtamo, J.
AU  - Virtanen, M.
AU  - Albanes, D.
AU  - Tangrea, J. A.
AU  - Huttunen, J. K.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1999///
VL  - 8
IS  - 6
SP  - 489
EP  - 493
SN  - 1055-9965
AD  - Malila, N.: Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20001408705.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 7235-40-7, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - This study was carried out within the α-Tocopherol, β-Carotene Cancer Prevention Study (ATBC Study), whose participants were randomly assigned to 4 supplementation groups: (a) α-tocopherol (AT), 50 mg/day; (b) β-carotene (BC), 20 mg/day; (c) both AT and BC; and (d) placebo. 15 538 ATBC Study participants (aged 50-69 years) who had been randomized within the areas of 3 major cities in southern Finland were included. Cases of colorectal adenoma (n=146) were identified by the pathology laboratories in the study areas, and these participants' medical records were collected and reviewed. α-Tocopherol supplementation increased the risk for adenomas (relative risk, 1.66; 95% confidence interval, 1.19-2.32), whereas β-carotene supplementation had no effect on the risk (relative risk, 0.98; 95% confidence interval, 0.71-1.35). Slightly more pre-diagnosis rectal bleeding and intestinal pain occurred in those adenoma cases who received α-tocopherol supplements than in those who did not. Thus, some bias may have resulted, with α-tocopherol supplementation leading to more colonoscopies and, thus, to an increased detection of incident polyps in this group. This is further supported by the trial finding that α-tocopherol supplementation did not increase the risk of colorectal cancer.
KW  - adenoma
KW  - beta-carotene
KW  - colorectal cancer
KW  - digestive tract
KW  - men
KW  - neoplasms
KW  - risk factors
KW  - supplements
KW  - tobacco smoking
KW  - vitamin E
KW  - vitamins
KW  - Finland
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancers
KW  - gastrointestinal tract
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001408705&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of vitamin intervention on the relationship between GSTM1, smoking, and lung cancer risk among male smokers.
AU  - Woodson, K.
AU  - Stewart, C.
AU  - Barrett, M.
AU  - Bhat, N. K.
AU  - Virtamo, J.
AU  - Taylor, P. R.
AU  - Albanes, D.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1999///
VL  - 8
IS  - 11
SP  - 965
EP  - 970
SN  - 1055-9965
AD  - Woodson, K.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892-7058, USA.
N1  - Accession Number: 20001412645.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 59-02-9, 7235-40-7, 50812-37-8, 1406-18-4.  Subject Subsets: Human Nutrition
N2  - The GSTM1 (glutathione S-transferase mu-1) null genotype is suspected of increasing an individual's susceptibility to tobacco smoke carcinogens because of impaired carcinogen detoxification. The aim of this work was to discover whether there were differences in lung cancer susceptibility to smoking within the GSTM1 genotypes and the impact of antioxidant supplementation on this. The study was a nested lung cancer case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. GSTM1 genotype status was determined for 319 cases and 333 controls using a PCR-based approach. GSTM1 was evaluated as an independent risk factor and as an effect modifier of smoking using logistic regression analyses. The GSTM1 null genotype itself was unrelated to risk of lung cancer, odds ratio (OR)=1.09 and 95% confidence interval (CI), 0.79-1.50, but it may have modified the effect of smoking. There was a suggestion for a stronger association between years of smoking and lung cancer among the GSTM1 null genotype, but the differences between GSTM1 null and present genotypes were not statistically significant (P=0.12). Furthermore, the smoking association was strongest among those with the GSTM1 null genotype not receiving α-tocopherol supplementation, whereas among those receiving α-tocopherol, there was no modification by GSTM1 on the association between smoking duration and lung cancer risk. β-Carotene supplementation did not modify the relationship between GSTM1, smoking years, and lung cancer risk. In conclusion, GSTM1 is not associated with lung cancer risk in male smokers but may confer a higher susceptibility to cumulative tobacco exposure. This association may be attenuated by α-tocopherol but not by β-carotene supplementation.
KW  - alpha-tocopherol
KW  - antioxidants
KW  - beta-carotene
KW  - genotypes
KW  - glutathione transferase
KW  - lung cancer
KW  - neoplasms
KW  - risk
KW  - supplements
KW  - susceptibility
KW  - tobacco smoking
KW  - vitamin E
KW  - Finland
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancers
KW  - ligandin
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412645&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effect of β-carotene supplementation on serum vitamin D metabolite concentrations.
AU  - Freedman, D. M.
AU  - Tangrea, J. A.
AU  - Virtamo, J.
AU  - Albanes, D.
JO  - Cancer Epidemiology, Biomarkers & Prevention
JF  - Cancer Epidemiology, Biomarkers & Prevention
Y1  - 1999///
VL  - 8
IS  - 12
SP  - 1115
EP  - 1116
SN  - 1055-9965
AD  - Freedman, D. M.: Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 7087, 6220 Executive Boulevard, Bethesda, Maryland 20892-7238, USA.
N1  - Accession Number: 20001417926.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 59-02-9, 7235-40-7, 32222-06-3, 1406-16-2.  Subject Subsets: Human Nutrition
N2  - In the α-Tocopherol, β-Carotene Cancer Prevention (ATBC) study, a large randomized placebo-controlled trial designed to test the cancer prevention effects of α-tocopherol (50 mg/day) and β-carotene (20 mg/day), participants receiving supplemental β-carotene had significantly higher rates of lung cancer than those not receiving β-carotene. It has been hypothesized that the supplemental β-carotene may have interfered with the synthesis of vitamin D and that the resulting lower concentrations of vitamin D contributed to the elevated cancer incidence. We evaluated whether supplementation with β-carotene altered the serum concentrations of either 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D in the ATBC Study, by comparing on-study changes between baseline and follow-up serum samples among 20 randomly selected matched pairs of subjects from the β-carotene and placebo groups. In a matched-pair analysis, the difference between the changes in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the β-carotene supplement and placebo groups were small and statistically non-significant. These results provide no evidence that β-carotene supplementation interferes with the endogenous production of 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D and suggest that it is unlikely that an interaction between supplemental β-carotene and vitamin D metabolites contributed to the modest increase in lung cancer incidence observed in the ATBC Study.
KW  - alpha-tocopherol
KW  - beta-carotene
KW  - calcitriol
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - prevention
KW  - synthesis
KW  - vitamin D
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - 1,25-dihydroxycholecalciferol
KW  - 1,25-dihydroxyvitamin D
KW  - cancers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adipose S14 mRNA is abnormally regulated in obese subjects.
AU  - Kirschner, L. S.
AU  - Mariash, C. N.
JO  - Thyroid
JF  - Thyroid
Y1  - 1999///
VL  - 9
IS  - 2
SP  - 143
EP  - 148
AD  - Kirschner, L. S.: National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19991412858.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - In rat hepatocyte culture, the S14 gene is necessary for induction of lipogenesis by carbohydrate metabolism and thyroid hormone. To determine if this gene plays a role in regulation of lipid storage in man, the response to fasting of the human S14 gene was compared in obese and nonobese subjects. The relative content of human S14 mRNA was measured in abdominal subcutaneous fat before and after a 48-h fast. mRNA-S14 was strongly downregulated in nonobese subjects in response to the fast, but only minimally down-regulated in obese subjects. There was an excellent correlation between body mass index, and the fasting induced fall in S14 mRNA. There was no difference in the postfasting glucose, insulin, and ketone levels between the 2 groups of subjects. Therefore, the S14 gene is abnormally downregulated during fasting in adipose tissue of obese individuals. Further study of this gene could provide important information on the mechanism of the acquisition or maintenance of obesity in man.
KW  - adipose tissue
KW  - anthropometric dimensions
KW  - body measurements
KW  - carbohydrate metabolism
KW  - fasting
KW  - genetics
KW  - height
KW  - insulin
KW  - lipogenesis
KW  - messenger RNA
KW  - obesity
KW  - regulation
KW  - storage
KW  - thyroid gland
KW  - thyroid hormones
KW  - weight
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - anthropometric measurements
KW  - fatness
KW  - lipid formation
KW  - mRNA
KW  - thyroid
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991412858&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human herpesvirus 7.
AU  - Black, J. B.
AU  - Pellett, P. E.
JO  - Reviews in Medical Virology
JF  - Reviews in Medical Virology
Y1  - 1999///
VL  - 9
IS  - 4
SP  - 245
EP  - 262
SN  - 1052-9276
AD  - Black, J. B.: National Institutes of Health, National Cancer Institute, HIV and AIDS Malignancy Branch, 10 Center Drive Building 10, Room 13N240, Bethesda, MD 20892, USA.
N1  - Accession Number: 20002007398.  Publication Type: Journal Article.  Language: English.  Number of References: 114 ref. Subject Subsets: Public Health
N2  - Biological properties (isolation and propagation, life cycle, latency and persistence and effect on host cell), genomic and genetic properties, proteins, epidemiology and disease associations, diagnostic tools, and treatment are reviewed.
KW  - clinical aspects
KW  - diagnosis
KW  - drug therapy
KW  - epidemiology
KW  - genetics
KW  - human diseases
KW  - pathogenesis
KW  - proteins
KW  - reviews
KW  - Herpesviridae
KW  - human herpesvirus 7
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Roseolovirus
KW  - Betaherpesvirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - clinical picture
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Diagnosis of Human Disease (VV720) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Iron status and the risk of coronary heart disease.
AU  - Sempos, C. T.
AU  - Looker, A. C.
JO  - Nutrition Metabolism and Cardiovascular Diseases
JF  - Nutrition Metabolism and Cardiovascular Diseases
Y1  - 1999///
VL  - 9
IS  - 6
SP  - 294
EP  - 303
CY  - Milano; Italy
PB  - Medikal Press s.r.l.
SN  - 0939-4753
AD  - Sempos, C. T.: Office of Research on Minority Health, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 20013024889.  Publication Type: Journal Article.  Language: English.  Number of References: 102 ref. Registry Number: 7439-89-6.  Subject Subsets: Human Nutrition
N2  - This article reviews the epidemiological evidence that body iron stores may be directly associated with an increased risk of CHD or indirectly associated through such oxidation.
KW  - cardiovascular diseases
KW  - heart diseases
KW  - iron
KW  - nutritional state
KW  - reviews
KW  - risk factors
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - coronary diseases
KW  - nutritional status
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses.
AU  - Slattery, J. P.
AU  - Franchini, G.
AU  - Gessain, A.
JO  - Genome Research
JF  - Genome Research
Y1  - 1999///
VL  - 9
IS  - 6
SP  - 525
EP  - 540
AD  - Slattery, J. P.: Laboratory of Genomic Diversity, National Cancer Institute-Frederick Research Development Center (NCI-FCRDC) Frederick, Maryland 21702, USA.
N1  - Accession Number: 19992011572.  Publication Type: Journal Article.  Language: English.  Number of References: 4 pp of ref.
N2  - Using both env and long terminal repeat (LTR) sequences, with maximal representation of genetic diversity within primate strains, the unique evolutionary history of human and simian T-cell leukemia/lymphotropic viruses (HTLV/STLV) is revised and expanded. Based on the robust application of 3 different phylogenetic algorithms of minimum evolution-neighbour joining, maximum parsimony, and maximum likelihood, overall levels of genetic diversity, specific rates of mutation within and between different regions of the viral genome, relatedness among viral strains from geographically diverse regions, and estimation of the pattern of divergence of the virus into extant lineages are addressed. Despite broad genomic similarities, type I and type II viruses do not share concordant evolutionary histories. HTLV-I/STLV-I are united through distinct phylogeographic patterns, infection of 20 primate species, multiple episodes of interspecies transmission, and exhibition of a range in levels of genetic divergence. In contrast, type II viruses are isolated from only 2 species (Homo sapiens and Pan paniscus) and are paradoxically endemic to both Amerindian tribes of the New World and human Pygmy villagers in Africa. Furthermore, HTLV-II is spreading rapidly through new host populations of intravenous drug users. Despite such clearly disparate host populations, the resultant HTLV-II/STLV-II phylogeny exhibits little phylogeographic concordance and indicates low levels of transcontinental genetic differentiation. Together, these patterns generate a model of HTLV/STLV emergence marked by an ancient ancestry, differential rates of divergence, and continued global expansion.
KW  - evolution
KW  - genetic diversity
KW  - genetics
KW  - human diseases
KW  - mutations
KW  - phylogenetics
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - man
KW  - Primates
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - simian t-cell lymphotropic virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011572&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA).
AU  - Dorgan, J. F.
AU  - Brock, J. W.
AU  - Rothman, N.
AU  - Needham, L. L.
AU  - Miller, R.
AU  - Stephenson, H. E., Jr.
AU  - Schussler, N.
AU  - Taylor, P. R.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1999///
VL  - 10
IS  - 1
SP  - 1
EP  - 11
SN  - 0957-5243
AD  - Dorgan, J. F.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Room 443, 6130 Executive Boulevard, Bethesda, MD 20892-7374, USA.
N1  - Accession Number: 20002008216.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 118-74-1. 
N2  - To prospectively evaluate relationships of organochlorine pesticides and polychlorinated biphenyls (PCBs) with breast cancer, a case-control study nested in a cohort was conducted in the USA using the Columbia, Missouri Breast Cancer Serum Bank. Women donated blood in 1977-87, and during up to 9.5 years follow-up, 105 donors who met the inclusion criteria for the current study were diagnosed with breast cancer. For each case, 2 controls matched on age and date of blood collection were selected. Five DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] analogs, 13 other organochlorine pesticides, and 27 PCBs were measured in serum. Women in the upper 3 quartiles of hexachlorobenzene were at twice the risk of breast cancer compared to those in the lowest quartile. However, there was no evidence for a dose-response relationship, and the association was limited to women whose blood was collected close to the time of diagnosis. Women with higher serum levels of other organochlorine pesticides and PCBs showed no increased risk of breast cancer overall, although positive associations were suggested for PCB-118 and PCB-138 when blood was collected close to the time of diagnosis. It is concluded that results of this study do not support a role for organochlorine pesticides and PCBs in breast cancer aetiology.
KW  - aetiology
KW  - breast cancer
KW  - epidemiology
KW  - hexachlorobenzene
KW  - human diseases
KW  - neoplasms
KW  - organochlorine compounds
KW  - organochlorine pesticides
KW  - polychlorinated biphenyls
KW  - risk factors
KW  - women
KW  - Missouri
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - HCB
KW  - organic chlorine compounds
KW  - organic chlorine pesticides
KW  - PCBs
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Tobacco and alcohol use and oral cancer in Puerto Rico.
AU  - Hayes, R. B.
AU  - Bravo-Otero, E.
AU  - Kleinman, D. V.
AU  - Brown, L. M.
AU  - Fraumeni, J. F., Jr.
AU  - Harty, L. C.
AU  - Winn, D. M.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1999///
VL  - 10
IS  - 1
SP  - 27
EP  - 33
SN  - 0957-5243
AD  - Hayes, R. B.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPN 418, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001409128.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Human Nutrition
N2  - In Puerto Rico, alcohol and tobacco use were compared among non-salivary gland cancers of the mouth and pharynx (n=342), cancers of major and minor salivary glands (n=25) and 521 population-based controls. Alcohol (usual use, Ptrend&lt;0.0001 for men and Ptrend=0.02 for women) and tobacco (usual use, Ptrend&lt;0.0001, for both men and women) were strong independent risk factors for oral cancer in Puerto Rico, with a multiplicative effect from combined exposures. Risks did not vary systematically by use of filter vs non-filter cigarettes. Risks with use of other forms of smoked tobacco were about sevenfold among both men and women. Risks decreased only gradually after cessation of tobacco and alcohol use. Tobacco use, but not alcohol, was linked to cancers of the salivary glands. The burden of oral cancer due to alcohol and tobacco use in Puerto Rico (76% for men, 52% for women) agreed closely with earlier estimates for the mainland US population, while about 72% of salivary gland cancer (men and women, combined) was due to tobacco use. It is concluded that excess risks for oral cancer in Puerto Rico are largely explained by patterns of alcohol and tobacco use. Smoking filter vs non filter cigarettes does not alter risk, while cessation of alcohol and tobacco use appears to reduce risk only gradually.
KW  - alcoholic beverages
KW  - consumption
KW  - head and neck cancer
KW  - men
KW  - mouth
KW  - neoplasms
KW  - pharynx
KW  - risk factors
KW  - salivary glands
KW  - tobacco smoking
KW  - women
KW  - Puerto Rico
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Latin America
KW  - cancers
KW  - Porto Rico
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
KW  - Sugar and Sugar Products (QQ020) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Calculation of population attributable risk for alcohol and breast cancer (United States).
AU  - Tseng, M.
AU  - Weinberg, C. R.
AU  - Umbach, D. M.
AU  - Longnecker, M. P.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1999///
VL  - 10
IS  - 2
SP  - 119
EP  - 123
SN  - 0957-5243
AD  - Tseng, M.: National Institute of Environmental Health Sciences Epidemiology Branch, Research Triangle Park, P.O. Box 12233 MD A3-05, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 20001410742.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Human Nutrition
N2  - Because of increasing evidence that alcohol may be causally associated with breast cancer, the population attributable risk (PAR) for alcohol and breast cancer for the US adult female population was reconsidered using an effect estimate from a meta-analysis and incorporating a revised perspective on measurement error correction. To estimate PAR, a formula appropriate to use with an adjusted effect estimate was employed. To estimate intermediate quantities needed to apply that formula, adjusted relative risk estimates from a previously published meta-analysis, as well as SEER cancer statistics and general population data from the third National Health and Nutrition Examination Survey were used. Relative risk estimates uncorrected for measurement error were used. The estimated age-adjusted PAR for alcohol and breast cancer was 2.1%. Because of the modest association between alcohol and breast cancer and the generally moderate level of alcohol intake among US women, the proportion of breast cancer attributable to alcohol intake is small. Widespread efforts to reduce alcohol consumption would not have a substantial impact on breast cancer rates in this population. While selected subgroups of women might benefit from decreasing alcohol consumption, specific profiles for such women have yet to be defined and defended.
KW  - alcoholic beverages
KW  - breast cancer
KW  - consumption
KW  - diet
KW  - neoplasms
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - United States of America
KW  - Sugar and Sugar Products (QQ020) 
KW  - Human Nutrition (General) (VV100) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410742&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Association between alcohol and lung cancer in the alpha-tocopherol, beta-carotene cancer prevention study in Finland.
AU  - Woodson, K.
AU  - Albanes, D.
AU  - Tangrea, J. A.
AU  - Rautalahti, M.
AU  - Virtamo, J.
AU  - Taylor, P. R.
JO  - Cancer Causes & Control
JF  - Cancer Causes & Control
Y1  - 1999///
VL  - 10
IS  - 3
SP  - 219
EP  - 226
SN  - 0957-5243
AD  - Woodson, K.: Cancer Prevention Studies Branch, 6006 Executive Boulevard - Suite 321, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-7058, USA.
N1  - Accession Number: 20001411516.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Human Nutrition
N2  - The association between alcohol intake and lung cancer was evaluated in a trial-based cohort in Finland, the α-tocopherol, β-carotene Cancer Prevention Study (ATBC Study). During an average of 7.7 years of follow-up, 1059 lung cancer cases were diagnosed among the 27 111 male smokers with complete alcohol and dietary information. The relationship between alcohol and lung cancer was assessed in multivariate Cox regression models that adjusted for age, smoking, body mass index and intervention group. Non drinkers, 11% of the study population, were at increased lung cancer risk compared to drinkers (RR=1.2, 95% CI: 1.0-1.4), possibly due to the inclusion of ex-drinkers who had stopped drinking for health reasons. Among drinkers only, no association between lung cancer and total ethanol or specific beverage (beer, wine, spirits) intake were observed. No significant effect of modification by level of smoking, dietary micronutrients or trial intervention group was found; however, for men in the highest quartile of alcohol intake, a slight increase in risk for lighter smokers (&lt;1 pack/day) and reduced risk among the heaviest smokers (&gt;30 cigarettes/day) was observed. It is concluded that alcohol consumption was not a risk factor for lung cancer among male cigarette smokers, and its effect was not significantly modified by other factors, notably smoking history.
KW  - alcoholic beverages
KW  - anthropometric dimensions
KW  - consumption
KW  - diet
KW  - lifestyle
KW  - lung cancer
KW  - men
KW  - neoplasms
KW  - nutrition surveys
KW  - tobacco smoking
KW  - Finland
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - anthropometric measurements
KW  - cancers
KW  - nutritional surveys
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Human Nutrition (General) (VV100) 
KW  - Sugar and Sugar Products (QQ020) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001411516&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum HIV-1 p24 antibody, HIV-1 RNA copy number and CD4 lymphocyte percentage are independently associated with risk of mortality in HIV-1-infected children.
AU  - Mofenson, L. M.
AU  - Harris, D. R.
AU  - Rich, K.
AU  - Meyer, W. A.
AU  - Read, J. S.
AU  - Moye, J., Jr.
AU  - Nugent, R. P.
AU  - Korelitz, J.
AU  - Bethel, J.
AU  - Pahwa, S.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
IS  - 1
SP  - 31
EP  - 39
SN  - 0269-9370
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children National Institute of Child Health and Human Development, Westat, Rockville, Maryland, USA.
N1  - Accession Number: 19992007107.  Publication Type: Journal Article.  Corporate Author: National Institute of Child Health and Human Development USA, Intravenous Immunoglobulin Clinical Trial Study Group Language: English.  Number of References: 43 ref. Registry Number: 63231-63-0. 
N2  - The association between HIV-1 p24 antibody, HIV-1 RNA, immune complex-dissociated (ICD) p24 antigen, CD4 cell percentage and mortality were evaluated in a cohort of 218 HIV-infected children. The children were enrolled in mainland USA and Puerto Rico during March 1988 to January 1991 in a trial of intravenous immunoglobulin prophylaxis of bacterial infections. CD4 cell percentage was measured and sera collected and stored at baseline and every 3 months. Stored sera were assayed for HIV-1 p24 antibody, HIV-1 RNA, and ICD p24 antigen. Mortality was recorded during the trial and updated through 1996 (mean total follow-up, 6.3 years). 81 children (37%) died; probability of mortality for children with baseline HIV-1 p24 antibody concentrations of undetectable (&lt;1), 1-4, 5-124 and ≥125 reciprocal titre units (RTU) was 61, 50, 24 and 10%, respectively. A 3.5-fold increase in the relative risk (RR) of death (95% confidence interval (CI), 2.2-5.5) was observed among children with baseline HIV-1 p24 antibody concentration &lt;5 RTU compared with ≥5 RTU. In multivariate analyses, p24 antibody, HIV-1 RNA and CD4 cell percentage, but not ICD p24 antigen, were independently associated with mortality; the RR of death increased by 1.7 (95% CI, 1.3-2.1) for each log10 decrease in baseline HIV-1 p24 antibody. It is concluded that HIV-1 p24 antibody, HIV-1 RNA and CD4 cell percentage independently predict mortality amongst infected children. Whereas CD4 cell percentage provides an estimate of the general degree of immune suppression, HIV-1 p24 antibody could provide an easily obtained, inexpensive assessment of CD4 cell function and could augment prognostic information provided by CD4 cell count and viral load for clinical management of infected children.
KW  - CD4+ lymphocytes
KW  - children
KW  - core protein p24
KW  - human diseases
KW  - mortality
KW  - risk factors
KW  - RNA
KW  - viral diseases
KW  - Colombia
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - CD4+ cells
KW  - death rate
KW  - human immunodeficiency virus type 1
KW  - p24
KW  - p24 antigen
KW  - ribonucleic acid
KW  - T4 lymphocytes
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero.
AU  - Olivero, O. A.
AU  - Shearer, G. M.
AU  - Chougnet, C. A.
AU  - Kovacs, A. A. S.
AU  - Landay, A. L.
AU  - Baker, R.
AU  - Stek, A. M.
AU  - Khoury, M. M.
AU  - Proia, L. A.
AU  - Kessler, H. A.
AU  - Sha, B. E.
AU  - Tarone, R. E.
AU  - Poirier, M. C.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
IS  - 8
SP  - 919
EP  - 925
SN  - 0269-9370
AD  - Olivero, O. A.: Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA.
N1  - Accession Number: 19992008672.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 9007-49-2, 30516-87-1. 
N2  - In this prospective cohort study conducted in Chicago, Illinois, USA, DNA was extracted from peripheral blood mononuclear cells (PBMC) obtained from 28 non-pregnant adults and 12 pregnant women given zidovudine (ZDV) therapy, 6 non-pregnant adults with no exposure to ZDV and 6 non-pregnant adults who last received ZDV ≥6 months previously. In addition, DNA from cord blood leukocytes obtained from 22 infants of HIV-1-positive, ZDV-exposed women and from 12 infants unexposed to ZDV was analysed. There were 11 mother-infant pairs involving HIV-1-positive women. DNA samples were assayed for ZDV incorporation by anti-ZDV radioimmunoassay (RIA). The majority (76%) of samples from ZDV-exposed individuals, pregnant women (8 of 12), non-pregnant adults (24 of 28), or infants at delivery (15 of 22), had detectable ZDV-DNA levels. The range of positive values for ZDV-treated adults and infants was 25-544 and 22-452 molecules ZDV/106 nucleotides, respectively. Analysis of 11 mother-infant pairs showed variable ZDV-DNA incorporation in both, with no correlation by pair or by duration of drug treatment during pregnancy. Two of the 24 samples from individuals designated as controls were positive by anti-ZDV RIA. The 20-fold range for ZDV-DNA values in both adults and infants suggested large interindividual differences in ZDV phosphorylation. In conclusion, incorporation of ZDV into DNA was detected in most of the samples from ZDV-exposed adults and infants. The interindividual variability of ZDV incorporation into DNA in humans is considerable and consistent with reported variability in the formation of the ZDV-trisphosphate.
KW  - blood
KW  - cord blood
KW  - DNA
KW  - drug therapy
KW  - HIV-1 infections
KW  - human diseases
KW  - neonates
KW  - phosphorylation
KW  - pregnancy
KW  - zidovudine
KW  - Illinois
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - East North Central States of USA
KW  - AZT
KW  - chemotherapy
KW  - deoxyribonucleic acid
KW  - gestation
KW  - human immunodeficiency virus type 1
KW  - newborn infants
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-specific immunity following immunization with HIV synthetic envelope peptides in asymptomatic HIV-infected patients.
AU  - Pinto, L. A.
AU  - Berzofsky, J. A.
AU  - Fowke, K. R.
AU  - Little, R. F.
AU  - Merced-Galindez, F.
AU  - Humphrey, R.
AU  - Ahlers, J.
AU  - Dunlop, N.
AU  - Cohen, R. B.
AU  - Steinberg, S. M.
AU  - Nara, P.
AU  - Shearer, G. M.
AU  - Yarchoan, R.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
IS  - 15
SP  - 2003
EP  - 2012
SN  - 0269-9370
AD  - Pinto, L. A.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Bethesda Maryland 20892, USA.
N1  - Accession Number: 20002006138.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref.
N2  - A phase I trial was conducted in the USA to evaluate the safety and immunogenicity of an HIV synthetic peptide vaccine in HIV-seropositive individuals [date not given]. The immunogens used in this study were PCLUS 3-18MN and PCLUS 6.1-18MN envelope peptides. Eight HIV-infected patients received six subcutaneous injections of 160 µg PCLUS 3-18MN in Montanide ISA 51 and were followed longitudinally for a year after the first immunization. Peripheral blood mononuclear cells (PBMC) were tested for peptide-specific T helper and cytotoxic T cell (CTL) responses, HIV-1MN neutralizing antibodies and antibodies against HIV PCLUS 3 and P18 MN peptides. PCLUS 3-18MN-specific T helper responses were significantly increased at 36 weeks (P&lt;0.05, after adjustment for multiple comparisons) following initial immunization with PCLUS 3-18MN. A P18MN-specific CTL response, not present prior to vaccination, was observed after immunization in one patient. Serum HIV-1MN-neutralizing antibody titres increased in each of the three patients who had low titres prior to immunization. Plasma HIV RNA levels and CD4 cell counts did not change appreciably during the study period. This trial demonstrates that both peptides can be safely administered to HIV-infected individuals and that PCLUS 3-18MN induces increases in HIV peptide-specific immune responses.
KW  - antigens
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - immunization
KW  - neutralizing antibodies
KW  - safety
KW  - synthetic peptides
KW  - T lymphocytes
KW  - vaccination
KW  - vaccines
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006138&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Molecular interactions of HIV with host factors.
AU  - Strebel, K.
AU  - Bour, S.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
SP  - S13
EP  - S24
SN  - 0269-9370
AD  - Strebel, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA.
N1  - Accession Number: 19992011736.  Publication Type: Journal Article.  Language: English.  Number of References: 160 ref.
KW  - gene expression
KW  - HIV infections
KW  - host parasite relationships
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - molecular biology
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011736&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Immune reconstitution in HIV infection.
AU  - Gea-Banacloche, J. C.
AU  - Lane, H. C.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
SP  - S25
EP  - S38
SN  - 0269-9370
AD  - Gea-Banacloche, J. C.: Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992011737.  Publication Type: Journal Article.  Language: English.  Number of References: 163 ref.
KW  - CD4+ lymphocytes
KW  - CD8+ lymphocytes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immune response
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4+ cells
KW  - CD8+ cells
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - immunity reactions
KW  - immunological reactions
KW  - T4 lymphocytes
KW  - T8 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011737&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of nonhuman primates in the development of an AIDS vaccine.
AU  - Nathanson, N.
AU  - Hirsch, V. M.
AU  - Mathieson, B. J.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
SP  - S113
EP  - S120
SN  - 0269-9370
AD  - Nathanson, N.: Office of AIDS Research, National Institutes of Health, US Department of Health and Human Services, Room 4C02, Building 31, 9000 Rockville Pike, Bethesda, MD 20892-2340, USA.
N1  - Accession Number: 19992011743.  Publication Type: Journal Article.  Language: English.  Number of References: 74 ref.
KW  - acquired immune deficiency syndrome
KW  - animal models
KW  - disease models
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - reviews
KW  - vaccine development
KW  - vaccines
KW  - man
KW  - Primates
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011743&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies.
AU  - Erickson, J. W.
AU  - Gulnik, S. V.
AU  - Markowitz, M.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
SP  - S189
EP  - S204
SN  - 0269-9370
AD  - Erickson, J. W.: Structural Biochemistry Program, SAIC-Frederick, National Cancer Institute-FCRDC, Frederick, MD 21702, USA.
N1  - Accession Number: 19992011748.  Publication Type: Journal Article.  Language: English.  Number of References: 88 ref.
KW  - antiviral agents
KW  - cross resistance
KW  - drug resistance
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - proteinase inhibitors
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - protease inhibitors
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011748&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interruption of materno-fetal transmission.
AU  - Mofenson, L. M.
AU  - Fowler, M. G.
JO  - AIDS
JF  - AIDS
Y1  - 1999///
VL  - 13
SP  - S205
EP  - S214
SN  - 0269-9370
AD  - Mofenson, L. M.: Clinical Research, Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA.
N1  - Accession Number: 19992011749.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Registry Number: 30516-87-1. 
KW  - antiviral agents
KW  - disease prevention
KW  - disease transmission
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - pregnancy
KW  - prophylaxis
KW  - reviews
KW  - zidovudine
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AZT
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011749&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Rickettsiae and chlamydiae: evidence of horizontal gene transfer and gene exchange.
AU  - Wolf, Y. I.
AU  - Aravind, L.
AU  - Koonin, E. V.
JO  - Trends in Genetics
JF  - Trends in Genetics
Y1  - 1999///
VL  - 15
IS  - 5
SP  - 173
EP  - 175
SN  - 0168-9525
AD  - Wolf, Y. I.: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
N1  - Accession Number: 20000503304.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
KW  - gene transfer
KW  - hosts
KW  - molecular genetics
KW  - Chlamydia trachomatis
KW  - Rickettsia prowazekii
KW  - Chlamydia
KW  - Chlamydiaceae
KW  - Chlamydiales
KW  - Chlamydiae
KW  - Bacteria
KW  - prokaryotes
KW  - Rickettsia
KW  - Rickettsiaceae
KW  - Rickettsiales
KW  - Alphaproteobacteria
KW  - Proteobacteria
KW  - bacterium
KW  - biochemical genetics
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000503304&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Oral immunisation of mice with live Japanese encephalitis virus induces a protective immune response.
AU  - Ramakrishna, C.
AU  - Anita Desai
AU  - Shankar, S. K.
AU  - Chandramuki, A.
AU  - Ravi, V.
JO  - Vaccine
JF  - Vaccine
Y1  - 1999///
VL  - 17
IS  - 23/24
SP  - 3102
EP  - 3108
SN  - 0264-410X
AD  - Ramakrishna, C.: Department of Neurovirology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, India.
N1  - Accession Number: 19990506007.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - The efficacy of oral immunization of mice with live Japanese encephalitis virus (JEV) was evaluated. Swiss albino mice were immunized with JEV by the peroral (PO), intraperitoneal (IP) and the subcutaneous (SC) routes on days 0, 7 and 14 using either mouse brain derived immunogen (MBDI) or cell culture derived immunogen (CCDI). Oral immunization of mice evoked high anti-JEV antibody titres by ELISA (Geometric mean titres of 5065 with CCDI and 8854 with MBDI). Moreover, the orally immunized mice showed 76.7% protection with MBDI and 70% with CCDI against intracerebral challenge with a lethal dose of JEV. This study demonstrates for the first time that oral immunization of mice with live JEV generates a brisk, protective immune response.
KW  - antibodies
KW  - arboviruses
KW  - immune response
KW  - immunization
KW  - Japanese encephalitis
KW  - laboratory animals
KW  - Japanese encephalitis virus
KW  - mice
KW  - Flavivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - arthropod-borne viruses
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Serum vitamin A concentrations in a North American cohort of human immunodeficiency virus type 1-infected children.
AU  - Read, J. S.
AU  - Bethel, J.
AU  - Harris, D. R.
AU  - Meyer, W. A., III
AU  - Korelitz, J.
AU  - Mofenson, L. M.
AU  - Moye, J., Jr.
AU  - Savita Pahwa
AU  - Rich, K.
AU  - Nugent, R. P.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1999///
VL  - 18
IS  - 2
SP  - 134
EP  - 142
SN  - 0891-3668
AD  - Read, J. S.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA.
N1  - Accession Number: 19991405703.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - The study measured serum retinol concentrations among 207 HIV-infected children (aged between 1 month and 12 years) in the National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial, between 1988-1991. Changes in retinol concentrations were examined and the relationships between retinol concentrations and morbidity and mortality were investigated. Blood was collected from children at baseline and at 3-month intervals throughout the study. The rate of change in retinol concentrations, calculated by fitting a linear regression model, was expressed as µg/dl yearly. The median retinol concentration at baseline was 31.0 µg/dl. The rate of change in retinol concentrations (n=180) did not vary significantly by any factor other than baseline retinol concentration. Baseline retinol concentration was not associated with morbidity (incidence of infections, growth failure, CD4+ percent decline below 15%, increases in serum HIV RNA concentrations above either 105 or 106 copies/ml or acute care hospitalization). Neither baseline retinol concentration nor the rate of change of retinol concentration was associated with mortality. It is concluded that among these North American children with relatively normal retinol concentrations, retinol was not observed to be associated with morbidity or mortality.
KW  - blood
KW  - blood chemistry
KW  - children
KW  - HIV infections
KW  - human immunodeficiency viruses
KW  - infants
KW  - morbidity
KW  - mortality
KW  - retinol
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - death rate
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991405703&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Increased adherence of fluconazole-resistant isolates of Candida species to explanted esophageal mucosa.
AU  - Lyman, C. A.
AU  - Garrett, K. F.
AU  - Peter, J.
AU  - Gonzalez, C.
AU  - Walsh, T. J.
JO  - European Journal of Clinical Microbiology & Infectious Diseases
JF  - European Journal of Clinical Microbiology & Infectious Diseases
Y1  - 1999///
VL  - 18
IS  - 3
SP  - 213
EP  - 216
SN  - 0934-9723
AD  - Lyman, C. A.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991201675.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 86386-73-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - The adherence of fluconazole-resistant and fluconazole-susceptible isolates of C. albicans to explanted rabbit oesophageal mucosa was examined in vivo. Among 6 C. albicans isolates collected from HIV-infected patients, 3 fluconazole-resistant (MIC &gt;64 µg/ml) isolates attached more avidly than 3 fluconazole-susceptible strains (MIC ≤0.5 µg/ml) to oesophageal mucosa (P≤0.05). When 3 strains each of 6 different Candida spp. were compared, the more inherently fluconazole-resistant isolates adhered more avidly in the following order: C. glabrata [Torulopsis glabrata] &gt; C. krusei &gt; C. albicans fluconazole-sensitive &gt; C. tropicalis &gt; C. parapsilosis. However, fluconazole-resistant C. albicans demonstrated the greatest degree of adherence in comparison to all fluconazole-susceptible C. albicans (P&lt;0.001) and to all Candida spp. tested (P&lt;0.001). It is concluded that the refractoriness of oesophageal candidosis in patients infected with fluconazole-resistant isolates may be related to both in vitro drug resistance and increased mucosal adherence.
KW  - adhesion
KW  - antifungal agents
KW  - antifungal properties
KW  - candidosis
KW  - drug resistance
KW  - fluconazole
KW  - in vitro
KW  - physiology
KW  - susceptibility
KW  - testing
KW  - Candida acidothermophilum
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida parapsilosis
KW  - Candida tropicalis
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Torulopsis
KW  - Pezizomycotina
KW  - anti-fungal properties
KW  - Candida krusei
KW  - candidiasis
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201675&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Body weight and prior depletion affect plasma ascorbate levels attained on identical vitamin C intake: a controlled-diet study.
AU  - Block, G.
AU  - Mangels, A. R.
AU  - Patterson, B. H.
AU  - Levander, O. A.
AU  - Norkus, E. P.
AU  - Taylor, P. R.
JO  - Journal of the American College of Nutrition
JF  - Journal of the American College of Nutrition
Y1  - 1999///
VL  - 18
IS  - 6
SP  - 628
EP  - 637
SN  - 0731-5724
AD  - Block, G.: National Cancer Institute, Bethesda, USA.
N1  - Accession Number: 20001410219.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - The aim of the study was to evaluate the role of factors that may affect the level of plasma ascorbic acid (AA), including age, body weight, physical activity, minor illness and the impact of prior depletion and repletion. After 1 month of stabilization on 60 mg AA/day, subjects underwent 2 complete depletion-repletion cycles (one cycle=one month of AA depletion with 9 mg/day, followed by 1 month of repletion with 117 mg/day). Subjects (68 men, aged 30 to 59 years) did not smoke or drink alcohol during the study. All food was provided by the study. There was extreme individual variability in the plasma AA level achieved on an identical repletion dose: after 4 weeks at 117 mg/day of AA, AA ranged from 26.8 to 85.8 µmol/litre. Body weight was inversely associated with plasma AA attained (p&lt;0.0001). Regression analysis indicated that, compared to a 130-lb man, a 200-lb man reached 10 µmol/litre lower AA after the first repletion and 18 µmol/litre lower AA after the second repletion. One-third of the subjects did not reach a plasma plateaux after the first repletion. Prior depletion and apparent repletion also had a major impact, and only 10% of subjects reached the same plasma AA on the second repletion as on the first repletion. It is concluded that plasma AA attained on a given dose depends on body weight (or dose per kg of body weight) and on whether or not any prior depletions had been repleted adequately. The results have implications for nutrition recommendations and research design.
KW  - age
KW  - ascorbic acid
KW  - blood
KW  - blood chemistry
KW  - body weight
KW  - depletion
KW  - diet
KW  - men
KW  - physical activity
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410219&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Amphotericin B lipid complex in pediatric patients with invasive fungal infections.
AU  - Walsh, T. J.
AU  - Seibel, N. L.
AU  - Arndt, C.
AU  - Harris, R. E.
AU  - Dinubile, M. J.
AU  - Reboli, A.
AU  - Hiemenz, J.
AU  - Chanock, S. J.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1999///
VL  - 18
IS  - 8
SP  - 702
EP  - 708
SN  - 0891-3668
AD  - Walsh, T. J.: Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19991202620.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety and antifungal efficacy of amphotericin B lipid complex (ABLC, Abelcet) in 111 treatment episodes in paediatric patients were evaluated in an open label, emergency use multicentre study in the USA. Patients with invasive fungal infections were enrolled if they had mycoses refractory to conventional antifungal therapy, if they were intolerant of previous systemic antifungal agents or concomitant nephrotoxic drugs or if they had pre-existing renal disease. All 111 treatment episodes were evaluable for safety and 54 were evaluable for efficacy. The mean serum creatinine for the study population did not significantly change between baseline (1.23±0.11 mg/dl) and cessation of ABLC therapy (1.32±0.12 mg/dl) during 6 weeks. There were no significant differences observed between initial and end-of-therapy levels of serum potassium, magnesium, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and haemoglobin. However, there was an increase in mean total bilirubin (3.66±0.73 to 5.31±1.09 mg/dl) at the end of therapy (P=0.054). Among 54 cases fulfilling criteria for evaluation of antifungal efficacy, a complete or partial therapeutic response was obtained in 38 patients (70%) after ABLC therapy. Complete or partial therapeutic response was documented in 56% of cases with Aspergillus infection (n=25) and in 81% (n=27) with Candida infection. Among premature infants (n=8) and allogeneic marrow recipients (n=14), response rates were 88 and 57%, respectively. The response was similar in those patients enrolled due to intolerance to previous antifungal therapy or because of progressive infection. It is concluded that these results support the use of ABLC for the treatment of invasive fungal infections in paediatric patients who are intolerant or refractive to conventional antifungal therapy.
KW  - amphotericin B
KW  - antifungal agents
KW  - application methods
KW  - aspergillosis
KW  - candidosis
KW  - children
KW  - drug formulations
KW  - drug therapy
KW  - efficacy
KW  - human diseases
KW  - infections
KW  - lipids
KW  - mycoses
KW  - safety
KW  - USA
KW  - Aspergillus
KW  - Candida
KW  - fungi
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - candidiasis
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - lipins
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lyme disease vaccine.
AU  - Gerber, M. A.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1999///
VL  - 18
IS  - 9
SP  - 825
EP  - 826
SN  - 0891-3668
AD  - Gerber, M. A.: National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 20000502837.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref.
KW  - human diseases
KW  - Lyme disease
KW  - vaccines
KW  - Borrelia burgdorferi
KW  - man
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - lyme borreliosis
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Low incidence of human papillomavirus type 16 antibody seroconversion in young children.
AU  - Manns, A.
AU  - Strickler, H. D.
AU  - Wiktor, S. Z.
AU  - Pate, E. J.
AU  - Gray, R.
AU  - Waters, D.
JO  - Pediatric Infectious Disease Journal
JF  - Pediatric Infectious Disease Journal
Y1  - 1999///
VL  - 18
IS  - 9
SP  - 833
EP  - 835
SN  - 0891-3668
AD  - Manns, A.: National Cancer Institute, 6120 Executive Blvd., Room 8008, MSC 7248, Rockville, MD 20852, USA.
N1  - Accession Number: 20002007686.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref.
KW  - antibodies
KW  - disease transmission
KW  - human diseases
KW  - infants
KW  - neonates
KW  - seroconversion
KW  - Jamaica
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - Papillomaviridae
KW  - human papillomavirus
KW  - newborn infants
KW  - Papovaviridae
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Responsiveness of selenoproteins to dietary selenium.
AU  - Allan, C. B.
AU  - Lacourciere, G. M.
AU  - Stadtman, T. C.
JO  - Annual Review of Nutrition
JF  - Annual Review of Nutrition
Y1  - 1999///
VL  - 19
SP  - 1
EP  - 16
SN  - 0199-9885
AD  - Allan, C. B.: NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19991414994.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 7782-49-2.  Subject Subsets: Human Nutrition
N2  - A review.
KW  - diets
KW  - intake
KW  - reviews
KW  - selenium
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - selenoproteins
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS.
AU  - Shearer, G. M.
AU  - Pinto, L. A.
AU  - Clerici, M.
JO  - Immunology Today
JF  - Immunology Today
Y1  - 1999///
VL  - 20
IS  - 2
SP  - 66
EP  - 71
SN  - 0167-4919
AD  - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992005055.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref.
KW  - acquired immune deficiency syndrome
KW  - disease prevention
KW  - HIV infections
KW  - immunization
KW  - immunotherapy
KW  - reviews
KW  - vaccines
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - alloimmunization
KW  - human immunodeficiency virus infections
KW  - immune sensitization
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Relationship between event rates and treatment effects in clinical site differences within multicenter trials: an example from primary Pneumocystis carinii prophylaxis.
AU  - Ioannidis, J. P. A.
AU  - Dixon, D. O.
AU  - McIntosh, M.
AU  - Albert, J. M.
AU  - Bozzette, S. A.
AU  - Schnittman, S. M.
JO  - Controlled Clinical Trials
JF  - Controlled Clinical Trials
Y1  - 1999///
VL  - 20
IS  - 3
SP  - 253
EP  - 266
SN  - 0197-2456
AD  - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19991202425.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 80-08-0, 100-33-4, 140-64-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - A diagnostic approach for evaluating the diversity observed in results of multicentre clinical trials, that emphasizes the relationship between the observed event rates and treatment effects, is presented. As an example, a trial of sequential strategies of Pneumocystis prophylaxis in HIV infection with 842 patients randomly allocated to start prophylaxis with trimethoprim/sulfamethoxazole, dapsone or pentamidine, is used. Prophylaxis failure rates varied significantly across the 30 clinical sites (0-30.3%; P=0.002 by Fisher's exact test) with prominent variability in the pentamidine arm (0-63.6%). Starting with oral regimens was better than starting with pentamidine in sites with high rates of events, whereas the 3 strategies had more similar efficacy in other sites. Sites enrolling fewer patients had lower event rates and had more patients who withdrew prematurely or were lost to follow-up. In a hierarchical regression model adjusting for random measurement error in the observed event rates, starting with trimethoprim/sulfamethoxazole was predicted to be increasingly better than starting with aerosolized pentamidine as the risk of prophylaxis failure increased (P=0.01), reducing the risk of failure by 47% when the failure rate of pentamidine was 30%, whereas the 2 regimens were predicted to be equivalent when the failure rate was 17%. Differences in event rates could reflect a combination of heterogeneity in diagnosis, administration of treatments, and disease risk in patients across sites. It is suggested that the evaluation of clinical site differences with a systematic approach focusing on event rates may give further insight in the interpretation of the results of multicentre trials beyond an average treatment effect.
KW  - aerosols
KW  - clinical aspects
KW  - clinical trials
KW  - dapsone
KW  - disease prevention
KW  - drug therapy
KW  - efficacy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - mycoses
KW  - opportunistic infections
KW  - pentamidine
KW  - pneumocystosis
KW  - prophylaxis
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - chemotherapy
KW  - clinical picture
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - sulfamethoxazole trimethoprim
KW  - trimethoprim sulfamethoxazole
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Cervical dysplasia on cervicovaginal Papanicolaou smear among HIV-1-infected pregnant and nonpregnant women.
AU  - Stratton, P.
AU  - Prabodh Gupta
AU  - Riester, K.
AU  - Fox, H.
AU  - Zorrilla, C.
AU  - Tuomala, R.
AU  - Eriksen, N.
AU  - Vajaranant, M.
AU  - Minkoff, H.
AU  - Fowler, M. G.
JO  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF  - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1  - 1999///
VL  - 20
IS  - 3
SP  - 300
EP  - 307
AD  - Stratton, P.: National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
N1  - Accession Number: 19992004098.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
N2  - The association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors were studied in the USA. Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV-infected women were evaluated. The rates of SIL were compared with pregnancy status, immunosuppression, presence of sexually transmitted diseases (STDs) and demographic features. Rates of low grade SIL were similar for pregnant and nonpregnant HIV-1-infected women (17% and 23.8%, respectively; P=0.09). Of them, 12 women, 9 pregnant and 3 nonpregnant, had high grade SIL. None had invasive cervical cancer. Low CD4 percentage (odds ratio, [OR] = 3.8; 95% confidence interval [CI], 2.0-7.3) and inflammation (OR = 2.8; 95% CI, 1.8-4.3) were associated with SIL. An association between herpes simplex and SIL (OR = 3.3; 95% CI, 1.1-9.5) was less certain due to clinical diagnosis and low prevalence of herpes simplex (17 of 456 women). It is concluded that Pap smears for a cohort of HIV-infected pregnant and nonpregnant women revealed a high prevalence of LGSIL but a low prevalence of HGSIL and no cases of cervical cancer. Although pregnancy may not affect the rate of Pap smear abnormalities, SIL is associated with immunosuppression, cervical inflammation, and herpes simplex. Closer surveillance of HIV-1-infected women with these risk factors may be warranted.
KW  - cervical cancer
KW  - cervix
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lesions
KW  - neoplasms
KW  - pregnancy
KW  - women
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - gestation
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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ER  - 

TY  - JOUR
T1  - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) retards mammary gland involution in lactating Sprague-Dawley rats.
AU  - Venugopal, M.
AU  - Callaway, A.
AU  - Snyderwine, E. G.
JO  - Carcinogenesis
JF  - Carcinogenesis
Y1  - 1999///
VL  - 20
IS  - 7
SP  - 1309
EP  - 1314
SN  - 0143-3334
AD  - Venugopal, M.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 20001408440.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 9002-62-4.  Subject Subsets: Human Nutrition; Dairy Science
N2  - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic nitrogen compound from cooked meat, is an established mammary gland carcinogen in female rats. Four doses of PhIP (150 mg/kg, p.o., once per day) were given to lactating Sprague-Dawley rats separated from their 10-day-old pups to initiate involution of the gland. 24 h after the last dose, apoptotic index in the mammary gland, as measured by the TUNEL assay, was higher in the gland from control rats than in the PhIP-treated rats (4.757±1.066 versus 1.905±0.248%; P&lt;0.05). In comparison with controls, alveoli in the mammary gland of PhIP-treated rats were also visibly larger and contained more secretory epithelial cells. The expression of Bax, a stimulator of apoptosis, and Bcl-2, an inhibitor of apoptosis, were quantitated by western blotting. Accordingly, Bax expression was 2.7-fold higher in control rats, whereas Bcl-2 expression was 3.1-fold higher in PhIP-treated rats (Student's t-test, P&lt;0.05). Immunohistochemistry further confirmed a lower expression of Bax and higher expression of Bcl-2 in secretory alveolar epithelial cells of the PhIP-treated mammary gland. The findings are consistent with the notion that exposure to PhIP retarded involution via partial inhibition of programmed cell death. To investigate possible mechanisms for the inhibitory effects of PhIP on mammary gland involution, serum levels of prolactin, an important hormone for the maintenance of lactation, were measured in virgin rats with regular oestrous cycles given PhIP (150 mg/kg, p.o.) on the morning of dioestrous. After one oestrous cycle, on pro-oestrous morning, serum prolactin levels were 1.3-fold higher after PhIP than after control vehicle (one-way ANOVA, Fisher LSD multiple comparison test, P&lt;0.05). PhIP exposure during involution was associated with the induction of benign mammary tumours. Seven out of 12 rats developed fibroadenomas, and one developed a tubulo-papillary carcinoma within 1 year of receiving PhIP administration during involution (150 mg/kg, p.o., once per day for 5 days), and a high-fat diet (23.5% maize oil). An increase in serum prolactin level and the effects on mammary gland apoptosis seen with PhIP may have implications for the mechanisms of carcinogenic targeting of PhIP to the mammary gland.
KW  - apoptosis
KW  - carcinogenesis
KW  - carcinoma
KW  - heterocyclic nitrogen compounds
KW  - inhibition
KW  - involution
KW  - lactation
KW  - mammary glands
KW  - neoplasms
KW  - oestrous cycle
KW  - prolactin
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - breeding cycle
KW  - cancers
KW  - estrous cycle
KW  - lactogenic hormone
KW  - mammotropin
KW  - reproductive cycle
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia.
AU  - Salomon, D. S.
AU  - Bianco, C.
AU  - Santis, M. de
JO  - BioEssays
JF  - BioEssays
Y1  - 1999///
VL  - 21
IS  - 1
SP  - 61
EP  - 70
SN  - 0265-9247
AD  - Salomon, D. S.: Tumor Factor Growth Section, LTIB, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990401521.  Publication Type: Journal Article.  Language: English.  Number of References: 71 ref. Subject Subsets: Dairy Science
N2  - This review covers EGF (epidermal growth factor)-like growth factors in mammary gland development, EGF-like growth factors in mammary gland transformation and tumorigenesis, Cripto-1, a novel EGF-related protein, Cripto-1 expression, physicochemical properties of native and recombinant Cripto-1, Cripto-1 receptor and downstream signalling, Cripto-1 in mouse (Cr-1) and human (CR-1) mammary epithelial cells and Cripto-1 expression in human breast cancer cell lines and breast tumours. In the mouse, Cr-1 is expressed in the growing terminal end buds in the virgin mouse mammary gland and expression increases during pregnancy and lactation. Cr-1/CR-1 is overexpressed in mouse and human mammary tumours and inappropriate overexpression of Cr-1 in mouse mammary epithelial cells can lead to the clonal expansion of ductal hyperplasia. It is suggested that Cr-1/CR-1 performs a role in normal mammary gland development and that it might contribute to the early stages of mouse mammary tumorigenesis and the pathobiology of human breast cancer.
KW  - breast
KW  - breast cancer
KW  - epidermal growth factor
KW  - gene expression
KW  - growth factors
KW  - lactation
KW  - mammary development
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - milk proteins
KW  - neoplasms
KW  - pregnancy
KW  - receptors
KW  - recombinant proteins
KW  - reviews
KW  - women
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - breasts
KW  - cancers
KW  - gestation
KW  - mammary tumour
KW  - Milk and Dairy Produce (QQ010) 
KW  - General Physiology (ZZ340) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Laboratory Animal Science (LL040) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The effects of reducing sodium and increasing potassium intake for control of hypertension and improving health.
AU  - Cutler, J. A.
A2  - Chalmers, J.
JO  - Clinical and Experimental Hypertension
JF  - Clinical and Experimental Hypertension
Y1  - 1999///
VL  - 21
IS  - 5/6
SP  - 769
EP  - 783
AD  - Cutler, J. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20001412278.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 36 ref. Registry Number: 7440-09-7, 7440-23-5.  Subject Subsets: Human Nutrition
N2  - A review. From a world-wide, population perspective, the problem of excessive blood pressure levels for optimal cardiovascular health is immense and growing. Evidence from animal experimentation, observational epidemiology, and randomized clinical trials strongly support efforts to change nutritional factors in desirable directions, especially to lower dietary salt and increase potassium intake.
KW  - blood pressure
KW  - cardiovascular diseases
KW  - cardiovascular system
KW  - control
KW  - diets
KW  - epidemiology
KW  - health
KW  - hypertension
KW  - nutrition
KW  - potassium
KW  - reviews
KW  - salt
KW  - sodium
KW  - circulatory system
KW  - high blood pressure
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A multicenter, randomized, controlled trial of three preparations of low-dose oral α-interferon in HIV-infected patients with CD4+ counts between 50 and 350 cells/mm³.
AU  - Alston, B.
AU  - Ellenberg, J. H.
AU  - Standiford, H. C.
AU  - Muth, K.
AU  - Martinez, A.
AU  - Greaves, W.
AU  - Kumi, J.
JO  - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF  - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1  - 1999///
VL  - 22
IS  - 4
SP  - 348
EP  - 357
AD  - Alston, B.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7624, USA.
N1  - Accession Number: 20002009489.  Publication Type: Journal Article.  Corporate Author: USA, Division of AIDS Treatment Research Initiative (DATRI) 022 Study Group Language: English.  Number of References: 18 ref. Registry Number: 9008-11-1.  Subject Subsets: Public Health
N2  - The effectiveness of low-dose oral α-interferon (α-IFN) was evaluated in 247 human immunodeficiency virus (HIV)-infected study subjects who received placebo, Alferon LDO, Veldona, or Ferimmune in a randomized, double-blind trial conducted in the USA between April 1996 and July 1997. Subjects had CD4+ counts between 50 and 350 cells/mm³and HIV-related symptoms at entry. Study subjects rated the severity of 8 symptoms using a symptom burden index (SBI). Study endpoints included changes in SBI, weight, CD4+ count and Karnofsky score between baseline and the 24-week visit. The SBI outcome and weight were measured in 99 and 106 study subjects, respectively, at both the baseline and 24-week visits. Baseline SBI scores ranged from 5.4 to 7.9 in the 4 arms. No clinically important or statistically significant differences were found among the 4 arms with regard to SBI or weight change over the 24-week period. There were also no significant differences among the arms for CD4+ cell count and Karnofsky score. Few adverse reactions were noted in any arm, and there were no significant differences between arms. Although the trial was designed to enrol 560 study subjects and was prematurely terminated because of slow accrual and discontinuations of participants, it is concluded that the small differences among the arms in the primary and secondary endpoints do not support claims of efficacy for the measures studied.
KW  - adverse effects
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - drug formulations
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interferon
KW  - symptoms
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - CD4+ cells
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - T4 lymphocytes
KW  - United States of America
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009489&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects.
AU  - Weyer, C.
AU  - Snitker, S.
AU  - Rising, R.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1999///
VL  - 23
IS  - 7
SP  - 715
EP  - 722
SN  - 0307-0565
AD  - Weyer, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19991411277.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Human Nutrition
N2  - The aims of the study were to provide comprehensive prediction equations for 24 h energy expenditure (24-EE), sleeping metabolic rate (SMR) and 24 h respiratory quotient (24-RQ), based on a large number of Caucasian and Pima Indian subjects, covering a wide range of body weight and composition, body fat distribution, and age; and to test whether Pima Indians have lower metabolic rate and/or higher 24-RQ than Caucasians. 916 non-diabetic subjects (561 males, 355 females; 416 Caucasians, 500 Pima Indians; 720 with normal (NGT) and 196 with impaired (IGT) glucose tolerance), aged 31.5±11.9 years, body weight 90.5±26.1 kg (mean±s.d.), spent 24 h in a respiratory chamber for measurements of 24-EE, SMR and 24-RQ. Fat-free mass (FFM) and fat mass (FM) were assessed by either hydrodensitometry or dual energy X-ray absorptiometry (DEXA). Waist circumference and waist-to-thigh ratio (WTR) were determined as measures of body fat distribution. In a stepwise multiple regression analysis, FFM, FM, sex, age, WTR, and ethnicity were significant independent determinants of 24-EE (2258±422 kcal/day), explaining 85% of its variability (24-EE (kcal/day)= 696 + 18.9 FFM (kg) + 10.0 FM (kg) + 180 male-1.9 age + 7.1 WTR + 44 Pima Indian). SMR (1623±315 kcal/day) was determined (78% of variability) by FFM, FM, sex, age, WTR, and glucose tolerance (SMR (kcal/day)=443 + 14.6 FFM (kg) + 6.9 FM (kg) + 79 male-1.0 age + 5.8 WTR + 38 IGT), but not by ethnicity. Adjustment for the respective variables reduced the variance in 24-EE from 422 to 162 kcal/day and in SMR from 315 to 146 kcal/day. 24-RQ (0.854±0.026) was determined by waist circumference and energy balance (24-RQ=0.88429-0.00175 waist circumference + 0.00004 energy balance (%)), but not by sex, ethnicity or glucose tolerance. With this equation only 13% of the variability in 24-RQ could be explained (residual variance 0.024). Compared to Caucasians, Pima Indians had higher 24-EE, but similar SMR and 24-RQ. It is concluded that this analysis provides comprehensive prediction equations for 24-EE, SMR and 24-RQ from their major known determinants. It confirms the previous findings that, even after adjustment for body composition, age, sex, ethnicity, and glucose tolerance, there is still considerable variability in energy expenditure and substrate oxidation that may, in part, be genetically determined. In adult Pima Indians, no evidence for lower metabolic rate or impaired fat oxidation that could explain the propensity towards obesity in this ethnic group was found.
KW  - age
KW  - American indians
KW  - basal metabolism
KW  - body composition
KW  - body weight
KW  - energy
KW  - energy metabolism
KW  - ethnic groups
KW  - ethnicity
KW  - genetics
KW  - glucose tolerance
KW  - obesity
KW  - resting energy exchange
KW  - sex differences
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - basal energy exchange
KW  - blood sugar tolerance
KW  - ethnic differences
KW  - fatness
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411277&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Overweight prevalence among youth in the United States: why so many different numbers?
AU  - Troiano, R. P.
AU  - Flegal, K. M.
JO  - International Journal of Obesity
JF  - International Journal of Obesity
Y1  - 1999///
VL  - 23
SP  - S22
EP  - S27
SN  - 0307-0565
AD  - Troiano, R. P.: Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19991406467.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 51 ref. Subject Subsets: Human Nutrition
N2  - The variety and evolution among youth in the US are discussed. Issues of definition, measurements, criteria selection and comparison groups are considered and implications from estimates of the prevalance of overweight among youth are explored. Reference percentiles for body mass index from several publications are compared.
KW  - adolescents
KW  - analytical methods
KW  - anthropometric dimensions
KW  - body composition
KW  - body weight
KW  - children
KW  - guidelines
KW  - height
KW  - obesity
KW  - overweight
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - analytical techniques
KW  - anthropometric measurements
KW  - fatness
KW  - prevalence
KW  - recommendations
KW  - teenagers
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Reproduction and Development (VV060) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991406467&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Early infection in bone marrow transplantation: quantitative study of clinical factors that affect risk.
AU  - Engels, E. A.
AU  - Ellis, C. A.
AU  - Supran, S. E.
AU  - Schmid, C. H.
AU  - Barza, M.
AU  - Schenkein, D. P.
AU  - Koc, Y.
AU  - Miller, K. B.
AU  - Wong, J. B.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1999///
VL  - 28
IS  - 2
SP  - 256
EP  - 266
SN  - 1058-4838
AD  - Engels, E. A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Boulevard, EPN 434, Rockville, Maryland 20822, USA.
N1  - Accession Number: 19992003966.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Subject Subsets: Public Health
N2  - To examine clinical factors that affect infection risk, patients who received bone marrow transplants (53 autologous and 51 allogeneic) at New England Medical Center, Boston, USA were retrospectively studied. Over a median of 27 hospital days, 44 patients developed documented infections. Both autologous transplantation and haematopoietic growth factor use were associated with less prolonged neutropenia and decreased occurrence of infection (P≤0.05). In a survival regression model, variables independently associated with infection risk were the log10 of the neutrophil count (hazard ratio [HR], 0.49; 95% confidence interval [CI], 0.32-0.75), ciprofloxacin prophylaxis (HR, 0.42; 95% CI, 0.19-0.95), empirical intravenous antibiotic use (HR, 0.09; 95% CI, 0.03-0.32), and an interaction between neutrophil count and intravenous antibiotic use (HR, 1.86; 95% CI, 1.06-3.29). In this model, infection risk increases steeply at low neutrophil counts for patients receiving no antibiotic therapy. Ciprofloxacin prophylaxis and particularly intravenous antibiotic therapy provide substantial protection at low neutrophil counts. These results can be used to model management strategies for transplant recipients.
KW  - bone marrow transplant
KW  - clinical aspects
KW  - human diseases
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - risk factors
KW  - transplant recipients
KW  - Massachusetts
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - New England States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - clinical picture
KW  - recipients
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003966&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Treatment of hydrocephalus secondary to cryptococcal meningitis by use of shunting.
AU  - Park, M. K.
AU  - Hospenthal, D. R.
AU  - Bennett, J. E.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1999///
VL  - 28
IS  - 3
SP  - 629
EP  - 633
SN  - 1058-4838
AD  - Park, M. K.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991201428.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The clinical courses of 10 non-HIV-infected patients (7 men, 3 women; aged 17-66 years) from the USA, with hydrocephalus secondary to cryptococcal meningitis who underwent shunting procedures during 1967--95, were reviewed. Of these 10 patients who underwent shunting, 9 had noticeable improvement in dementia and gait. Two patients required late revision of their shunts. Shunt placement in 8 patients with acute infection did not disseminate cryptococcal infection into the peritoneum or bloodstream, nor did shunting provide a nidus from which Cryptococcus neoformans organisms proved difficult to eradicate. It is concluded that shunting procedures are a safe and effective therapy for hydrocephalus in patients with cryptococcal meningitis and need not be delayed until patients are mycologically cured.
KW  - central nervous system
KW  - clinical aspects
KW  - complications
KW  - cryptococcal meningitis
KW  - cryptococcosis
KW  - human diseases
KW  - hydrocephalus
KW  - infections
KW  - meningitis
KW  - treatment
KW  - USA
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - clinical picture
KW  - CNS
KW  - european blastomycosis
KW  - fungus
KW  - meningeal cryptococcosis
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201428&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Guide to major clinical trials of antiretroviral therapy in human immunodeficiency virus-infected patients: protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and nucleotide reverse transcriptase inhibitors.
AU  - Tavel, J. A.
AU  - Miller, K. D.
AU  - Masur, H.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1999///
VL  - 28
IS  - 3
SP  - 643
EP  - 676
SN  - 1058-4838
AD  - Tavel, J. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 115231, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19992007261.  Publication Type: Journal Article.  Language: English.  Number of References: 99 ref. Subject Subsets: Public Health
N2  - This review summarizes, in table format, studies that have shaped the principals of antiretroviral therapy, particularly clinical endpoint trials, proof-of-concept trials that have influenced the standard of care for human immunodeficiency virus treatment, double-blind, randomized trials and large trials with long-term patient follow-up. Smaller trials that address important questions are also included.
KW  - clinical trials
KW  - drug therapy
KW  - enzyme inhibitors
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - proteinase inhibitors
KW  - reverse transcriptase inhibitors
KW  - reviews
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - nucleotide reverse transcriptase inhibitors
KW  - protease inhibitors
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007261&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Predictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawi.
AU  - Ioannidis, J. P. A.
AU  - Taha, T. E.
AU  - Kumwenda, N.
AU  - Broadhead, R.
AU  - Mtimavalye, L.
AU  - Miotti, P.
AU  - Yellin, F.
AU  - Contopoulos-Ioannidis, D. G.
AU  - Biggar, R. J.
JO  - International Journal of Epidemiology
JF  - International Journal of Epidemiology
Y1  - 1999///
VL  - 28
IS  - 4
SP  - 769
EP  - 775
SN  - 0300-5771
AD  - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
N1  - Accession Number: 20002007904.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Registry Number: 56-95-1, 18472-51-0, 3697-42-5, 55-56-1. 
N2  - Predictors and the impact of losses to follow-up of infants born in a large cohort of delivering women in urban Malawi during June-November 1994, were studied. The cohort was established as part of a trial of vaginal cleaning with chlorhexidine during delivery to prevent mother-to-infant transmission of HIV. The HIV infection status could not be determined for 797 (36.9%) of 2156 infants born to HIV-infected mothers; 144 (6.7%) with missing status because of various sample problems and 653 (30.3%) because they never returned to the clinic. Notably, the observed rates of perinatal transmission were significantly lower in infants who returned later for determination of their infection status (odds ratio =0.94 per month, P=0.03), even though these infants must have had an additional risk of infection from breastfeeding. In multivariate models, infants of lower birthweight (P=0.003) and, marginally, singletons (P=0.09) were less likely to return for follow-up. The parents of infants lost to follow-up tended to be less educated (P&gt;0.001) and more likely to be in farming occupations, although one educated group, teachers and students, were also significantly less likely to return. Of these variables, infant birthweight, twins versus singletons, and maternal education were also associated with significant variation in the observed risk of perinatal transmission among infants of known HIV status. Several predictors of loss to follow-up were identified in this large HIV perinatal cohort. Losses to follow-up can impact the observed transmission rate and the risk associations in different studies.
KW  - birth weight
KW  - breast feeding
KW  - children
KW  - chlorhexidine
KW  - disease transmission
KW  - education
KW  - epidemiology
KW  - follow up
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - maternal transmission
KW  - mothers
KW  - neonates
KW  - occupations
KW  - urban areas
KW  - vagina
KW  - viral diseases
KW  - women
KW  - Africa
KW  - Malawi
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - newborn infants
KW  - Nyasaland
KW  - viral infections
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Women (UU500) 
KW  - Human Sexual and Reproductive Health (VV065) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Similarities between the pathogenesis of and immunity to diphtheria and pertussis: the complex nature of serum antitoxin - induced immunity to these two diseases.
AU  - Schneerson, R.
A2  - Cherry, J. D.
A2  - Robbins, J. B.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1999///
VL  - 28
SP  - S136
EP  - S139
SN  - 1058-4838
AD  - Schneerson, R.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Building 6, Room 424, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19992011669.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 62 ref. Registry Number: 308067-58-5. 
N2  - Similarities between the pathogenesis and immunity to pertussis and diphtheria are examined. As with pertussis, diphtheria toxoid vaccination confers only ~70% immunity on an individual basis, individuals with protective levels of antitoxin may contract diphtheria, and about 50% of the entire population, especially adults, have less than protective levels of antitoxin. The virtual disappearance of diphtheria followed vaccination of the entire population with diphtheria toxoid, which blocked transmission of toxigenic Corynebacterium diphtheriae and thus reduced the pathogen to almost undetectable levels. It is suggested that the individual and community-based immunity induced by diphtheria toxoid is similar to that of pertussis and pertussis toxoid.
KW  - antibodies
KW  - antitoxins
KW  - clinical aspects
KW  - diphtheria
KW  - human diseases
KW  - IgG
KW  - immunity
KW  - pathogenesis
KW  - pertussis
KW  - reviews
KW  - toxoids
KW  - vaccination
KW  - Corynebacterium diphtheriae
KW  - man
KW  - Corynebacterium
KW  - Corynebacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - clinical picture
KW  - whooping cough
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011669&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin A deficiency and other nutritional indices during pregnancy in human immunodeficiency virus infection: prevalence, clinical correlates, and outcome.
AU  - Burns, D. N.
AU  - FitzGerald, G.
AU  - Semba, R.
AU  - Hershow, R.
AU  - Zorrilla, C.
AU  - Pitt, J.
AU  - Hammill, H.
AU  - Cooper, E. R.
AU  - Fowler, M. G.
AU  - Landesman, S.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1999///
VL  - 29
IS  - 2
SP  - 328
EP  - 334
SN  - 1058-4838
AD  - Burns, D. N.: Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 20002007127.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - Vitamin A levels in plasma and other nutritional indices were measured during pregnancy for 449 women from the USA, enrolled in a multicentre cohort study of mother-to-infant transmission of human immunodeficiency virus type 1 (HIV-1). During the third trimester, 29.6% of the women had low (20 to &lt;30 µg/dl) and 11.1% had very low (&lt;20 µg/dl) vitamin A levels. Vitamin A and body mass index, serum albumin levels, and haemoglobin levels were weakly correlated. After adjustment for other covariates, women with low and very low vitamin A levels before the third trimester were more likely to deliver infants with low birth weight (&lt;2500 g) than were those with higher levels (odds ratio (OR), 4.58; 95% confidence interval (CI), 1.57-13.4; and OR, 6.99; 95% CI, 1.09-45.0, respectively). However, there was no statistically significant association between vitamin A level and mother-to-infant transmission of HIV-1. Anaemia and low body mass index before the third trimester were associated with an increased risk of transmission in univariate analyses but not in multivariate analyses.
KW  - albumins
KW  - anaemia
KW  - birth weight
KW  - blood plasma
KW  - clinical aspects
KW  - deficiency
KW  - disease transmission
KW  - haemoglobin
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infants
KW  - low birth weight infants
KW  - maternal transmission
KW  - nutrition
KW  - pregnancy
KW  - retinol
KW  - serum albumin
KW  - viral diseases
KW  - women
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - viruses
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - anemia
KW  - axerophthol
KW  - clinical picture
KW  - gestation
KW  - hemoglobin
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - plasma (blood)
KW  - United States of America
KW  - viral infections
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Women (UU500) 
KW  - Human Nutrition (General) (VV100) 
KW  - Human Reproduction and Development (VV060) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Albendazole therapy for loiasis refractory to diethylcarbamazine treatment.
AU  - Klion, A. D.
AU  - Horton, J.
AU  - Nutman, T. B.
JO  - Clinical Infectious Diseases
JF  - Clinical Infectious Diseases
Y1  - 1999///
VL  - 29
IS  - 3
SP  - 680
EP  - 682
SN  - 1058-4838
AD  - Klion, A. D.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20000804143.  Publication Type: Journal Article.  Language: English.  Number of References: 13 ref. Registry Number: 54965-21-8, 90-89-1, 1642-54-2.  Subject Subsets: Helminthology; Tropical Diseases
N2  - Three patients who had symptomatic loiasis refractory to more than 4 courses of diethylcarbamazine were treated orally with albendazole at 200 mg twice-daily for 21 days. At the time of treatment, all patients had persistent symptoms despite decreasing titres of antifilarial antibodies and normal eosinophil counts. Symptoms resolved in all 3 patients following albendazole therapy. In one patient, nonspecific symptoms recurred 2 years later but, unlike her symptoms before albendazole therapy, were not accompanied by the appearance of subcutaneous nodules containing adult worms. The other 2 patients remained symptom-free over 8 years of follow-up. Albendazole may be useful for the treatment of loiasis in cases when diethylcarbamazine is ineffective or cannot be used. All the patients were USA residents who had acquired Loa loa infections during temporary residence in Gabon.
KW  - albendazole
KW  - anthelmintics
KW  - diethylcarbamazine
KW  - drug therapy
KW  - helminths
KW  - human diseases
KW  - imported infections
KW  - loiasis
KW  - nematode infections
KW  - parasites
KW  - treatment failure
KW  - Gabon
KW  - USA
KW  - Loa loa
KW  - man
KW  - Loa
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - ACP Countries
KW  - Central Africa
KW  - Africa South of Sahara
KW  - Africa
KW  - Developing Countries
KW  - Francophone Africa
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - African eyeworm
KW  - chemotherapy
KW  - loaosis
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of surface molecules on salivary glands of the mosquito, Aedes aegypti, by a panel of monoclonal antibodies.
AU  - Barreau, C.
AU  - Conrad, J.
AU  - Fischer, E.
AU  - Lujan, H. D.
AU  - Vernick, K. D.
JO  - Insect Biochemistry and Molecular Biology
JF  - Insect Biochemistry and Molecular Biology
Y1  - 1999///
VL  - 29
IS  - 6
SP  - 515
EP  - 526
SN  - 0965-1748
AD  - Barreau, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990504947.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - Characterization of salivary gland surface molecules of A. aegypti was undertaken to identify candidate receptors for Plasmodium gallinaceum sporozoite invasion. Monoclonal antibodies (MAbs) were generated against antigen enriched for salivary gland membranes and basal lamina. A panel of 44 MAbs were generated that bound to surface molecules of mosquito tissues. 24 MAbs bound exclusively to salivary glands, 6 bound to salivary glands and ovaries, one bound to salivary gland and midgut, and 13 bound to all tissues tested. Data on the immunolocalization and biochemical characteristics of the antigens are presented. Many of the salivary gland-specific MAbs bound preferentially to the median and distal lateral lobes of the salivary glands, indicating that there are anatomical region-specific biochemical differences on the gland surface. These lobes of the salivary glands are the preferential sites of malaria sporozoite invasion. Therefore, antigens specific for these regions are promising candidate receptors for sporozoite invasion. The present identification of surface molecules of mosquito salivary glands by means of monoclonal antibodies represents the first description of individual molecules on the mosquito salivary gland surface.
KW  - antigens
KW  - binding sites
KW  - biochemistry
KW  - host parasite relationships
KW  - monoclonal antibodies
KW  - parasites
KW  - salivary glands
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - antigenicity
KW  - binding site
KW  - immunogens
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Apoptosis in a canine model of acute chagasic myocarditis.
AU  - Zhang Jun
AU  - Andrade, Z. A.
AU  - Yu ZuXi
AU  - Andrade, S. G.
AU  - Takeda, K.
AU  - Sadirgursky, M.
AU  - Ferrans, V. J.
JO  - Journal of Molecular and Cellular Cardiology
JF  - Journal of Molecular and Cellular Cardiology
Y1  - 1999///
VL  - 31
IS  - 3
SP  - 581
EP  - 596
AD  - Zhang Jun: Pathology Section, National Heart, Lung & Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990808148.  Publication Type: Journal Article.  Language: English.  Number of References: 49 ref. Subject Subsets: Protozoology
N2  - Six dogs were experimentally infected with Trypanosoma cruzi and necropsied 18 days later (considered to be the time of maximum intensity of acute myocarditis), as were 2 uninfected controls. The occurrence of apoptosis in the heart was investigated using confocal microscopy, nick end labelling (to detect the fragmentation of DNA, by 4 different techniques) and electron microscopy. Apoptosis was detected in cardiac myocytes (mainly those not infected by parasites), and in smaller numbers of blood vessel endothelial cells, immune effector cells and parasites. The significance of these findings is discussed.
KW  - apoptosis
KW  - Chagas' disease
KW  - endothelium
KW  - experimental infections
KW  - heart diseases
KW  - host parasite relationships
KW  - human diseases
KW  - immune response
KW  - laboratory animals
KW  - lymphocytes
KW  - macrophages
KW  - myocarditis
KW  - myocardium
KW  - parasites
KW  - pathogenesis
KW  - pathology
KW  - dogs
KW  - protozoa
KW  - Trypanosoma cruzi
KW  - Canis
KW  - Canidae
KW  - Fissipeda
KW  - carnivores
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Trypanosoma
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - cardiac muscle
KW  - coronary diseases
KW  - heart muscle
KW  - immunity reactions
KW  - immunological reactions
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
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DP  - EBSCOhost
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TY  - JOUR
T1  - Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks.
AU  - Greiner, R. S.
AU  - Moriguchi, T.
AU  - Hutton, A.
AU  - Slotnick, B. M.
AU  - Salem, N., Jr.
JO  - Lipids
JF  - Lipids
Y1  - 1999///
VL  - 34
SP  - S239
EP  - S243
SN  - 0024-4201
AD  - Greiner, R. S.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Division on Intramural Clinical and Biological Research, Rockville, Maryland, USA.
N1  - Accession Number: 19991413055.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 25167-62-8.  Subject Subsets: Human Nutrition
KW  - brain
KW  - docosahexaenoic acid
KW  - learning ability
KW  - mental ability
KW  - performance
KW  - smell
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - intelligence
KW  - learning capacity
KW  - olfaction
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The role of docosahexaenoic acid (22:6n-3) in neuronal signaling.
AU  - Kim HeeYong
AU  - Edsall, L.
JO  - Lipids
JF  - Lipids
Y1  - 1999///
VL  - 34
SP  - S249
EP  - S250
SN  - 0024-4201
AD  - Kim HeeYong: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA.
N1  - Accession Number: 19991413058.  Publication Type: Journal Article.  Language: English.  Number of References: 1 ref. Registry Number: 25167-62-8.  Subject Subsets: Human Nutrition
KW  - docosahexaenoic acid
KW  - nervous system
KW  - neurons
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - nerve cells
KW  - neurones
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract.
AU  - Plouzek, C. A.
AU  - Ciolino, H. P.
AU  - Clarke, R.
AU  - Yeh, G. C.
JO  - European Journal of Cancer
JF  - European Journal of Cancer
Y1  - 1999///
VL  - 35
IS  - 10
SP  - 1541
EP  - 1545
SN  - 0959-8049
AD  - Plouzek, C. A.: Cellular Defense and Carcinogenesis Section, Basic Research Laboratory, Division of Basic Science, National Cancer Institute-Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21701, USA.
N1  - Accession Number: 19990312381.  Publication Type: Journal Article.  Language: English.  Number of References: 19 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - The transmembrane transport pump P-glycoprotein (Pgp) causes the efflux of chemotherapeutic agents from cells and is believed to be an important mechanism in multidrug resistance (MDR) in mammary tumours. An extract of Rosmarinus officinalis increased the intracellular accumulation of commonly used chemotherapeutic agents, including doxorubicin (DOX) and vinblastine (VIN), in drug-resistant MCF-7 human breast cancer cells which express Pgp. The extract inhibited the efflux of DOX and VIN (known to be substrates of Pgp) but did not affect accumulation or efflux of DOX in wild type MCF-7 cells, which lack Pgp. Treatment of drug-resistant cells with the extract increased their sensitivity to DOX, which was consistent with an increased intracellular accumulation of the drug. The extract blocked the binding of the VIN analogue azidopine to Pgp.
KW  - cell lines
KW  - cell membranes
KW  - cytotoxicity
KW  - drug interactions
KW  - efflux
KW  - in vitro
KW  - medicinal plants
KW  - neoplasms
KW  - plant extracts
KW  - rosemary
KW  - tumours
KW  - man
KW  - Rosmarinus officinalis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Rosmarinus
KW  - Lamiaceae
KW  - Lamiales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - cancers
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - tumors
KW  - Plant Science (General) (FF000) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mortality among aerial pesticide applicators and flight instructors: follow-up from 1965-1988.
AU  - Cantor, K. P.
AU  - Silberman, W.
JO  - American Journal of Industrial Medicine
JF  - American Journal of Industrial Medicine
Y1  - 1999///
VL  - 36
IS  - 2
SP  - 239
EP  - 247
SN  - 0271-3586
AD  - Cantor, K. P.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS-8106, Bethesda, MD 20892-7240, USA.
N1  - Accession Number: 20001107289.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref. Subject Subsets: Agricultural Entomology; Weeds; Nematology; Plant Pathology
N2  - Vital status follow-up for a retrospective cohort mortality study of 9961 male aerial pesticide applicators was extended beyond a previous study (1965-1979), through 31 December, 1988. Rate ratios (RR) were used to compare directly adjusted mortality rates between applicators and a comparison cohort of 9969 flight instructors. Standardized mortality ratios (SMR) were calculated for comparisons with the USA white male population. Among applicator pilots, there were 1441 deaths, and among instructors, 1045. In both groups, aircraft accidents were the major cause of death (446 applicators; 234 instructors). Compared with flight instructors, aerial applicator pilots were at significantly elevated risk for all causes of death (risk ratio=1.34) and for malignant neoplasms (1.18), non-motor vehicle accidents (1.71), motor vehicle accidents (1.69), and stroke (1.91). Pancreatic cancer (2.71) and leukaemia (3.35) were significantly elevated. Applicators were at lower risk of colon cancer (0.51) and multiple myeloma (0.23) mortality. Based on USA rates, the SMR for all causes of death among applicators was 111 and among instructors, 81. Aircraft accidents were a major cause of mortality in both applicator and flight instructor cohorts. Several other causes of death, some possibly related to pesticide exposure, were also elevated among pesticide applicator pilots.
KW  - accidents
KW  - aerial application
KW  - aerial spraying
KW  - agricultural aviation
KW  - agricultural entomology
KW  - aircraft
KW  - carcinogenesis
KW  - colon
KW  - herbicides
KW  - leukaemia
KW  - mortality
KW  - myeloma
KW  - nematicides
KW  - nematology
KW  - neoplasms
KW  - nontarget effects
KW  - nontarget organisms
KW  - occupational hazards
KW  - pancreas
KW  - pesticides
KW  - plant pathology
KW  - stroke
KW  - USA
KW  - arthropods
KW  - man
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood cancer
KW  - cancers
KW  - death rate
KW  - leucaemia
KW  - leukemia
KW  - non-target organisms
KW  - non-target species
KW  - nontarget species
KW  - phytopathology
KW  - United States of America
KW  - weedicides
KW  - weedkillers
KW  - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW  - Occupational Health and Safety (VV900) 
KW  - Human Toxicology and Poisoning (VV810) (New March 2000)
KW  - Rural Health (VV550) (New March 2000)
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Isolation of DNA after extraction of RNA to detect the presence of Borrelia burgdorferi and expression of host cellular genes from the same tissue sample.
AU  - Amemiya, K.
AU  - Schaefer, H.
AU  - Pachner, A. R.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1999///
VL  - 37
IS  - 6
SP  - 2087
EP  - 2089
SN  - 0095-1137
AD  - Amemiya, K.: National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990504576.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 9007-49-2, 63231-63-0.  Subject Subsets: Medical & Veterinary Entomology
N2  - The neuropathogenesis of Lyme disease caused by B. burgdorferi was investigated in a nonhuman primate model. In the past, 2 separate pieces of tissue had to be used when both analysing for the presence of the spirochaete and examining the host response to infection. A procedure was modified to purify DNA from the same sample after the extraction of RNA. The remaining material containing the DNA was precipitated, and residual organic reagent was removed prior to deproteinization and extraction of the DNA. This procedure now allows assaying for the presence of the Lyme microorganism and analysis of the host response in the same tissue preparation.
KW  - detection
KW  - DNA
KW  - genes
KW  - hosts
KW  - immune response
KW  - isolation
KW  - Lyme disease
KW  - pathogenesis
KW  - RNA
KW  - techniques
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - deoxyribonucleic acid
KW  - immunity reactions
KW  - immunological reactions
KW  - lyme borreliosis
KW  - ribonucleic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recurrent bacteremia caused by a "Flexispira"-like organism in a patient with X-linked (Bruton's) agammaglobulinemia.
AU  - Weir, S.
AU  - Cuccherini, B.
AU  - Whitney, A. M.
AU  - Ray, M. L.
AU  - MacGregor, J. P.
AU  - Steigerwalt, A.
AU  - Daneshvar, M. I.
AU  - Weyant, R.
AU  - Wray, B.
AU  - Steele, J.
AU  - Strober, W.
AU  - Gill, V. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1999///
VL  - 37
IS  - 8
SP  - 2439
EP  - 2445
SN  - 0095-1137
AD  - Weir, S.: Microbiology Service, Clinical Pathology Department, W.G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992010306.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 1403-66-3, 1405-41-0, 64221-86-9.  Subject Subsets: Public Health
N2  - A patient in the USA with X-linked (Bruton's) agammaglobulinaemia was found to have persistent sepsis with a Helicobacter-like organism despite multiple courses of antibiotics. His periods of sepsis [between 1994 and 1997] were associated with leg swelling thought to be consistent with cellulitis. The organism was fastidious and required a microaerophilic environment containing H2 for growth. Optimal growth was observed at 35 to 37°C on sheep blood, CDC anaerobe, and Bordet-Gengou agars. Serial subcultures every 4 to 5 days were required to maintain viability. The organism was strongly urease positive and showed highest relatedness to Helicobacter-like organisms with the vernacular name "Flexispira rappini" by 16S rRNA gene sequence analysis. Genomic DNA hybridization studies, however, found 24 to 37% relatedness to "F. rappini" and even less to other Helicobacter spp. Although the organism phenotypically resembles "Flexispira" and Helicobacter, it is thought to represent a new taxon. The patient's infection was eventually cleared with a prolonged (5-month) course of intravenous imipenem and gentamicin.
KW  - bacteraemia
KW  - case reports
KW  - gentamicin
KW  - human diseases
KW  - imipenem
KW  - immunocompromised hosts
KW  - new taxa
KW  - sepsis
KW  - taxonomy
KW  - USA
KW  - Helicobacter
KW  - man
KW  - Helicobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacteremia
KW  - bacterium
KW  - Flexispira
KW  - systematics
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - An uncommon Helicobacter isolate from blood: evidence of a group of Helicobacter spp. pathogenic in AIDS patients.
AU  - Weir, S. C.
AU  - Gibert, C. L.
AU  - Gordin, F. M.
AU  - Fischer, S. H.
AU  - Gill, V. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1999///
VL  - 37
IS  - 8
SP  - 2729
EP  - 2733
SN  - 0095-1137
AD  - Weir, S. C.: Microbiology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19992010440.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Public Health
N2  - An unusual Helicobacter sp. was isolated from the blood of a human immunodeficiency virus (HIV)-infected patient in the USA in December 1997. This organism had spiral morphology, with single amphitrichous flagella, and was negative for hippurate hydrolysis, production of urease, and reduction of nitrate. 16S rRNA gene sequence analysis verified that the isolate was a species of Helicobacter, most closely related to an undescribed Helicobacter-like isolate from Vancouver, British Columbia, Canada, and to H. westmeadii, a recently described species from Australia. Both organisms had also been isolated from the blood of HIV-infected patients. These blood isolates, along with H. cinaedi, form a cluster of closely related Helicobacter spp. that may represent an emerging group of pathogens in immunocompromised patients.
KW  - acquired immune deficiency syndrome
KW  - case reports
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - pathogenicity
KW  - ribosomal RNA
KW  - USA
KW  - Helicobacter
KW  - man
KW  - Helicobacteraceae
KW  - Campylobacterales
KW  - Epsilonproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - bacterium
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - rRNA
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Taxonomy and Evolution (ZZ380) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010440&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evaluation of two rapid assays for detection of Clostridium difficile toxin A in stool specimens.
AU  - Fedorko, D. P.
AU  - Engler, H. D.
AU  - O'Shaughnessy, E. M.
AU  - Williams, E. C.
AU  - Reichelderfer, C. J.
AU  - Smith, W. I., Jr.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1999///
VL  - 37
IS  - 9
SP  - 3044
EP  - 3047
SN  - 0095-1137
AD  - Fedorko, D. P.: National Institutes of Health, Microbiology Service, CPD, Building 10, Room 2C385, 10 Center Dr. Msc 1508, Bethesda MD 20892-1508, USA.
N1  - Accession Number: 20002006497.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref.
N2  - A total of 654 stool specimens were tested to compare the performance of two assays for rapid detection of toxin A, the Immunocard Toxin A test (Meridian Diagnostics, Inc.) and the Culturette Brand Toxin CD enzyme immunoassay (EIA) (Becton Dickinson Microbiology Systems), with a cytotoxin assay (Cytotoxi Test; Advanced Clinical Diagnostics) and culture on cycloserine-cefoxitin-fructose agar followed by determination of the production of toxins A and B. A chart review was performed for patients whose stool specimens provided positive results on 1 to 3 of the assays. With the "gold standard" of all 4 assays positive or chart review evidence of Clostridium difficile-associated diarrhoea (CDAD), 97 (14.8%) stool specimens were positive by one or more assays and 557 (85.2%) were negative by all methods. Total agreement for all assays was 90.5% (592 of 654). The sensitivity, specificity, positive predictive value, and negative predictive value for toxigenic culture were 94.7, 98.6, 87.1, and 99.5%, respectively, for toxigenic culture; 87.7, 98.6, 86.2, and 98.8%, respectively, for the cytotoxin assay; 71.9, 99.3, 91.1, and 97.3%, respectively, for the Immunocard; and 68.4, 99.1, 88.6, and 96.9%, respectively, for the Culturette EIA. It is concluded that while easy to perform and highly specific, these rapid assays do not appear to be sufficient for accurate diagnosis of CDAD.
KW  - assays
KW  - bacterial diseases
KW  - clinical aspects
KW  - detection
KW  - diarrhoea
KW  - enzyme immunoassay
KW  - human diseases
KW  - laboratory diagnosis
KW  - rapid methods
KW  - techniques
KW  - toxins
KW  - Clostridium difficile
KW  - man
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - clinical picture
KW  - diarrhea
KW  - scouring
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Diagnosis of Human Disease (VV720) (New March 2000)
KW  - Techniques and Methodology (ZZ900) 
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TY  - JOUR
T1  - Combining high risk science with ambitious social and economic goals.
AU  - Rosenthal, J. P.
AU  - Beck, D.
AU  - Amar Bhat
AU  - Biswas, J.
AU  - Brady, L.
AU  - Bridbord, K.
AU  - Collins, S.
AU  - Cragg, G.
AU  - Edwards, J.
AU  - Fairfield, A.
AU  - Gottlieb, M.
AU  - Gschwind, L. A.
AU  - Hallock, Y.
AU  - Hawks, R.
AU  - Hegyeli, R.
AU  - Johnson, G.
AU  - Keusch, G. T.
AU  - Lyons, E. E.
AU  - Miller, R.
AU  - Rodman, J.
AU  - Roskoski, J.
AU  - Siegel-Causey, D.
T3  - Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups
JO  - Pharmaceutical Biology
JF  - Pharmaceutical Biology
Y1  - 1999///
VL  - 37
SP  - 6
EP  - 21
CY  - Lisse; Netherlands
PB  - Swets & Zeitlinger
SN  - 1388-0209
AD  - Rosenthal, J. P.: Fogarty International Center, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892-2220, USA.
N1  - Accession Number: 20003026607.  Publication Type: Journal Article.  Note: Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups Language: English.  Number of References: 52 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Plant Genetic Resources; Plant Breeding; Rural Development; Plant Pathology; Aromatic & Medicinal Plants; Tropical Diseases; Public Health; Agricultural Entomology
N2  - The International Cooperative Biodiversity Groups (ICBG) represent an experimental effort supported by 3 agencies of the US Government to integrate research in natural products drug discovery with efforts to build the scientific and economic capacity of developing countries as well as enhance the skills and incentives needed to conserve biological diversity. ICBG groups are unique, public-private collaborations that have been carrying out interdisciplinary research and development projects for up to 7 years in 12 developing countries (Latin America, Africa and Asia). In addition to research on species in 230 plant families and 25 arthropod orders, over 1400 individuals have received technical training, and potential therapies for several parasitic diseases, tuberculosis and crop diseases are in development. The ICBGs have also developed novel research and intellectual property agreements and have become important testing grounds in national and global discussions regarding access, informed consent and benefit-sharing associated with genetic resources.
KW  - conservation
KW  - economic development
KW  - genetic resources
KW  - intellectual property rights
KW  - natural products
KW  - phytochemicals
KW  - plant genetic resources
KW  - training
KW  - tuberculosis
KW  - Africa
KW  - Asia
KW  - Latin America
KW  - USA
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - gene resources
KW  - United States of America
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Biological Resources (Animal) (PP710) 
KW  - Biological Resources (Plant) (PP720) 
KW  - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000)
KW  - Natural Resource Economics (EE115) (New March 2000)
KW  - Education and Training (CC100) 
KW  - Agencies and Organizations (DD100) 
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Storage Problems and Pests of Non-food/Non-feed Plant Products (SS210) 
KW  - Residues and Contamination of Plant Products (SS220) (Discontinued March 2000)
KW  - Viral, Bacterial and Fungal Diseases of Plants (FF610) (New March 2000)
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DP  - EBSCOhost
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ER  - 

TY  - GEN
T1  - Drug Discovery, Economic Development and Conservation: The International Cooperative Biodiversity Groups.
AU  - Rosenthal, J. P.
A2  - Rosenthal, J. P.
T2  - Pharmaceutical Biology
T3  - Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups
JO  - Pharmaceutical Biology
JF  - Pharmaceutical Biology
Y1  - 1999///
VL  - 37
SP  - 144 PP.
EP  - 144 PP.
CY  - Lisse; Netherlands
PB  - Swets & Zeitlinger
SN  - 1388-0209
AD  - Rosenthal, J. P.: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892-2220, USA.
N1  - Accession Number: 20003026602.  Publication Type: Journal issue.  Note: Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups Language: English.  Subject Subsets: Plant Genetic Resources; Plant Breeding; Aromatic & Medicinal Plants; Forest Products; Tropical Diseases; Forestry; Public Health; Agricultural Entomology
N2  - This special supplement of the journal Pharmaceutical Biology outlines the efforts of the International Cooperative Biodiversity Groups (ICBG) Programme, funded by the US Government in partnership with industry, in supporting multidisciplinary international partnerships between research institutions, companies, communities and non-governmental organizations promoting bioprospecting for new pharmaceutical and agricultural agents. Currently, research, development and conservation efforts are being carried out in 12 developing countries, USA and UK. Of the 9 papers presented in this issue, 6 were presented at the Annual Meeting of the American Society of Pharmacognosy, Orlando, Florida, in 1998. These papers are considerably expanded in content and updated relative to the presentations that were made in Orlando. All papers describe the work of different groups funded by the ICBG Programme.
KW  - conservation
KW  - diversity
KW  - economic development
KW  - indigenous knowledge
KW  - intellectual property rights
KW  - international agreements
KW  - international cooperation
KW  - medicinal plants
KW  - medicinal properties
KW  - natural products
KW  - phytochemicals
KW  - plant genetic resources
KW  - Developing Countries
KW  - UK
KW  - USA
KW  - countries
KW  - British Isles
KW  - Western Europe
KW  - Europe
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - APEC countries
KW  - North America
KW  - America
KW  - Britain
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - Third World
KW  - Underdeveloped Countries
KW  - United Kingdom
KW  - United States of America
KW  - Biological Resources (Plant) (PP720) 
KW  - Biological Resources (Animal) (PP710) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Viral, Bacterial and Fungal Diseases of Plants (FF610) (New March 2000)
KW  - Plant Pests (FF620) (New March 2000)
KW  - Plant Composition (FF040) 
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Non-wood Forest Products (KK540) 
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ER  - 

TY  - JOUR
T1  - Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis.
AU  - Müller, F. M. C.
AU  - Kasai, M.
AU  - Francesconi, A.
AU  - Brillante, B.
AU  - Roden, M.
AU  - Peter, J.
AU  - Chanock, S. J.
AU  - Walsh, T. J.
JO  - Journal of Clinical Microbiology
JF  - Journal of Clinical Microbiology
Y1  - 1999///
VL  - 37
IS  - 10
SP  - 3405
EP  - 3408
SN  - 0095-1137
AD  - Müller, F. M. C.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19991202771.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The transmission of an azole-resistant, isogenic strain of C. albicans in an HIV-infected family from the USA, of 2 children with symptomatic oropharyngeal candidosis and a mother with asymptomatic colonization during a 5-year period, is reported. These findings were confirmed by 3 different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping.
KW  - antifungal agents
KW  - asymptomatic infections
KW  - azoles
KW  - candidosis
KW  - case reports
KW  - children
KW  - colonization
KW  - disease transmission
KW  - drug resistance
KW  - epidemiology
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - identification
KW  - immunocompromised hosts
KW  - infection
KW  - infections
KW  - mouth
KW  - opportunistic infections
KW  - pharynx
KW  - polymerase chain reaction
KW  - techniques
KW  - USA
KW  - Candida albicans
KW  - man
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - candidiasis
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - PCR
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Breakthrough Candida tropicalis fungemia during ketoconazole prophylaxis in cancer patients.
AU  - Krcmery, V., Jr.
AU  - Sejnova, D.
AU  - Pichnova, E.
JO  - Acta Oncologica
JF  - Acta Oncologica
Y1  - 1999///
VL  - 38
IS  - 5
SP  - 663
EP  - 665
SN  - 0001-6381
AD  - Krcmery, V., Jr.: St. Elisabeth and Pediatric National Cancer Institute, Heydukova 10, 812 50 Bratislava, Slovakia.
N1  - Accession Number: 20001201659.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 65277-42-1. 
KW  - blood
KW  - drug therapy
KW  - fungaemia
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - ketoconazole
KW  - mycoses
KW  - neoplasms
KW  - opportunistic infections
KW  - prophylaxis
KW  - Slovakia
KW  - Candida
KW  - Candida tropicalis
KW  - man
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - cancers
KW  - chemotherapy
KW  - fungemia
KW  - fungus
KW  - Hyphomycetes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification, cloning, and synthesis of a novel salivary anti-thrombin from the mosquito Anopheles albimanus.
AU  - Valenzuela, J. G.
AU  - Francischetti, I. M. B.
AU  - Ribeiro, J. M. C.
JO  - Biochemistry (Washington)
JF  - Biochemistry (Washington)
Y1  - 1999///
VL  - 38
IS  - 34
SP  - 11209
EP  - 11215
SN  - 0006-2960
AD  - Valenzuela, J. G.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive, MSC-0425 Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000505317.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 9002-04-4.  Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology
N2  - An anti-thrombin peptide (anophelin) was isolated from the salivary glands of A. albimanus through molecular sieving and reverse-phase high-performance liquid chromatography. The purified peptide inhibited thrombin-induced platelet aggregation, thrombin esterolytic activity on a synthetic substrate, and thrombin cleavage of fibrinogen. The purified anti-thrombin had a molecular mass of 6342.4 Da. Its amino terminus was blocked, but internal sequence yielded 3 peptide sequences, which were used to design oligonucleotide probes for PCR amplification of salivary gland cDNA and isolation of the full-length clone. Analysis of the sequence of anophelin shows no similarities to any other anti-thrombin peptides. Anophelin was successfully synthesized and characterized to be a tight-binding, specific, and novel inhibitor of thrombin. The new nucleotide sequence was deposited in the EMBL/GenBank/DDBJ database under accession number AF125095.
KW  - characterization
KW  - DNA cloning
KW  - inhibitors
KW  - molecular genetics
KW  - nucleotide sequences
KW  - peptides
KW  - salivary glands
KW  - thrombin
KW  - Anopheles albimanus
KW  - Culicidae
KW  - Diptera
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - anophelin
KW  - biochemical genetics
KW  - DNA sequences
KW  - mosquitoes
KW  - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
KW  - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.
AU  - Humphrey, R. W.
AU  - Wyvill, K. M.
AU  - Nguyen BachYen
AU  - Shay, L. E.
AU  - Kohler, D. R.
AU  - Steinberg, S. M.
AU  - Ueno, T.
AU  - Fukasawa, T.
AU  - Shintani, M.
AU  - Hayashi, H.
AU  - Mitsuya, H.
AU  - Yarchoan, R.
JO  - Antiviral Research
JF  - Antiviral Research
Y1  - 1999///
VL  - 41
IS  - 1
SP  - 21
EP  - 33
SN  - 0166-3542
AD  - Humphrey, R. W.: HIV and AIDS Malignancy Branch, Division of Clinical Sciences, National Cancer Institute, Building 10, Rm. 12N226, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992006610.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - The pharmacokinetics, toxicity, and activity of KNI-272, a transition state inhibitor of HIV-1 protease, was assessed in a phase I trial in Bethesda, Maryland, USA. After an initial phase in which the pharmacokinetics were assessed, 37 patients with AIDS or symptomatic HIV infection and 100-400 CD4 cells/mm³ were entered in an escalating dose study. KNI-272 was administered 4 times daily for up to 12 weeks. Oral bioavailability ranged from 22 to 55% and was not appreciably different in the fasting and post-prandial state. The dose limiting toxicity was hepatic transaminase elevation; this could be reduced by escalating the dose over 4 weeks. When administered this way, the maximum tolerated oral dose was 40 mg/kg per day. At the highest 2 tolerated doses (26.4 and 40 mg/kg per day), there was some evidence of an anti-HIV effect with median decreases of 0.2-0.3 log10 copies/ml plasma HIV RNA; these decreases persisted through 7-8 weeks of treatment. There was an upward trend in the CD4 count at the 40 mg/kg per day dose but not at other doses. Additional studies focused on approaches to improve the therapeutic index of KNI-272 may be warranted.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - antiviral properties
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - new drugs
KW  - pharmacokinetics
KW  - proteinase inhibitors
KW  - toxicity
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - anti-viral properties
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - protease inhibitors
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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TY  - JOUR
T1  - Visceral adipose tissue is not increased in Pima Indians compared with equally obese Caucasians and is not related to insulin action or secretion.
AU  - Gautier, J. F.
AU  - Milner, M. R.
AU  - Elam, E.
AU  - Chen, K.
AU  - Ravussin, E.
AU  - Pratley, R. E.
JO  - Diabetologia
JF  - Diabetologia
Y1  - 1999///
VL  - 42
IS  - 1
SP  - 28
EP  - 34
SN  - 0012-186X
AD  - Gautier, J. F.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, UK.
N1  - Accession Number: 19991411857.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Pima Indians are insulin resistant and hyperinsulinaemic compared with Caucasians. The study investigated whether abdominal fat distribution was different between Pimas and Caucasians and whether differences in the amount of visceral fat explained metabolic differences between the groups. Total body fat (absorptiometry) and abdominal fat distribution at L4-L5 (magnetic resonance imaging) were compared in 20 Pima Indians (10 men/10 women) and 20 age-, sex- and BMI-matched Caucasians. Insulin action was measured as glucose disposal during a two-step hyperinsulinaemic-euglycaemic glucose clamp and insulin secretion was assessed in response to oral and intravenous glucose tolerance tests. By design, percent body fat was similar in Pimas and Caucasians. Abdominal visceral and subcutaneous adipose tissue areas were also similar in the two groups (151±16 vs. 139±15 cm² and 489±61 vs. 441±57 cm² respectively). Plasma insulin concentrations were higher in Pimas than Caucasians in the fasting state (27±6 vs. 11±2 mU/ml; P&lt;0.01) and after a 75-g oral glucose load (area under the curve 19975±2626 vs. 9293±1847 mU/litre per 180 min; P&lt;0.005). Glucose disposal was lower in Pimas than Caucasians during both steps of the clamp and negatively correlated (after adjustment for percent body fat and sex) with visceral adipose tissue in Caucasians (partial r=-0.51, P=0.03), but not in Pima Indians (r=-0.03, P=0.92). Insulin secretion was not related to visceral fat independently of percent body fat in either group. It is concluded that a relative increase in visceral fat does not explain insulin resistance and hyperinsulinaemia in Pima Indians.
KW  - abdominal fat
KW  - adipose tissue
KW  - American indians
KW  - body fat
KW  - distribution
KW  - ethnic groups
KW  - fasting
KW  - glucose tolerance
KW  - hyperinsulinaemia
KW  - insulin
KW  - insulin secretion
KW  - obesity
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood sugar tolerance
KW  - fatness
KW  - hyperinsulinemia
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Social Structure (UU480) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Adherence of Candida albicans to bladder mucosa: development and application of a tissue explant assay.
AU  - Lyman, C. A.
AU  - Navarro, E.
AU  - Garrett, K. F.
AU  - Roberts, D. D.
AU  - Pizzo, P. A.
AU  - Walsh, T. J.
JO  - Mycoses
JF  - Mycoses
Y1  - 1999///
VL  - 42
IS  - 4
SP  - 255
EP  - 259
SN  - 0933-7407
AD  - Lyman, C. A.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991202123.  Publication Type: Journal Article.  Language: English.  Language of Summary: German.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - In order to study the interactions between Candida sp. and uroepithelial tissue, a tissue explant assay was developed using bladder mucosa harvested from New Zealand white rabbits. Blastoconidia of C. albicans, C. tropicalis and C. glabrata [Torulopsis glabrata] attached to the uroepithelial tissue in similar quantities. However, there was significantly more adherence to the uroepithelium by pre-germinated C. albicans compared with C. albicans blastoconidia. The amount of uroepithelial tissue injury was directly related to the length of exposure of the tissue to Candida. It is concluded that this tissue explant assay may provide a useful method for investigating properties related to fungal adherence to transitional uroepithelium and organism-mediated tissue injury.
KW  - adhesion
KW  - bladder
KW  - epithelium
KW  - interactions
KW  - trauma
KW  - Candida albicans
KW  - Candida glabrata
KW  - Candida tropicalis
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Torulopsis
KW  - Pezizomycotina
KW  - fungus
KW  - Hyphomycetes
KW  - Torulopsis glabrata
KW  - traumas
KW  - urinary bladder
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202123&site=ehost-live&scope=site
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients.
AU  - Piscitelli, S. C.
AU  - Kelly, G.
AU  - Walker, R. E.
AU  - Kovacs, J.
AU  - Falloon, J.
AU  - Davey, R. T., Jr.
AU  - Raje, S.
AU  - Masur, H.
AU  - Polis, M. A.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 3
SP  - 647
EP  - 650
SN  - 0066-4804
AD  - Piscitelli, S. C.: Department of Pharmacy, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992003998.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 3056-17-5. 
N2  - The effects of multiple opportunistic infection medications on stavudine pharmacokinetics were evaluated in a study in 1995 in the USA. 10 HIV-infected patients with CD4 counts of &lt;200 cells/mm³ received stavudine (40 mg twice daily) in combination with 1-3 other drugs used to treat opportunistic infections. Serial blood samples for stavudine concentrations were collected after 1 week of therapy on each regimen and assayed for stavudine by using a validated high-pressure liquid chromatography method. Although the maximum concentration of drug in serum was significantly decreased when the drug was given in combination with 3 opportunistic infection medications, the area under the concentration-time curve did not significantly differ across various treatment regimens. Stavudine exposure was not significantly altered by multiple concomitant medications. Side effects were minor throughout the 3-month study period. The tolerability of stavudine, combined with its lack of drug interactions, makes it an attractive agent for use as part of a combination regimen.
KW  - analogues
KW  - drug therapy
KW  - drugs
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - interactions
KW  - nucleoside analogues
KW  - nucleosides
KW  - opportunistic infections
KW  - pharmacokinetics
KW  - regimens
KW  - stavudine
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - analogs
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - medicines
KW  - nucleoside analogs
KW  - pharmaceuticals
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003998&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Sensitivity of spermidine-deficient Saccharomyces cerevisiae to paromomycin.
AU  - Balasundaram, D.
AU  - Tabor, C. W.
AU  - Tabor, H.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 5
SP  - 1314
EP  - 1316
SN  - 0066-4804
AD  - Balasundaram, D.: National Institutes of Health, Bethesda, MD 20892-0830, USA.
N1  - Accession Number: 19991201725.  Publication Type: Journal Article.  Language: English.  Number of References: 9 ref. Registry Number: 7542-37-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - Spermidine-deficient S. cerevisiae cells were more sensitive to paromomycin than nondeficient cells, resulting in cessation of growth and cell death.
KW  - antifungal agents
KW  - antifungal properties
KW  - paromomycin
KW  - susceptibility
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - aminosidine
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201725&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Heteroresistance to fluconazole and voriconazole in Cryptococcus neoformans.
AU  - Mondon, P.
AU  - Petter, R.
AU  - Amalfitano, G.
AU  - Luzzati, R.
AU  - Concia, E.
AU  - Polacheck, I.
AU  - Kwon-Chung, K. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 8
SP  - 1856
EP  - 1861
SN  - 0066-4804
AD  - Mondon, P.: Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991202460.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 86386-73-4, 137234-62-9.  Subject Subsets: Medical & Veterinary Mycology
N2  - C. neoformans isolates that exhibited unusual patterns of resistance to fluconazole and voriconazole were isolated from 7 isolates from 2 different geographical regions: one isolate from an Israeli non-AIDS patient and 6 serial isolates from an Italian AIDS patient who had suffered 6 recurrent episodes of cryptococcal meningitis. Each isolate produced cultures with heterogeneous compositions in which most of the cells were susceptible, but cells highly resistant to fluconazole (minimum inhibitory concentration (MIC) ≥64 µg/ml) were recovered at a variable frequency (7 × 10-3 to 4.6 × 10-2). Evidence showed that this type of resistance was innate and was unrelated to drug exposure since the Israeli patient had never been treated with azoles or any other antimycotic agents. Analysis of clonal subpopulations of these 2 strains showed that they exhibited heterogeneous patterns of resistance. The number of subpopulations which grew on fluconazole or voriconazole agar declined progressively with increasing azole concentration without a sharp cut-off point. For the Italian serial isolates, the number of clonal populations resistant to fluconazole (64 µg/ml) and voriconazole (1 µg/ml) increased steadily, yielding the highest number for the isolate from the last episode. Attempts to purify a sensitive subpopulation failed, but clones highly resistant to fluconazole (100 µg/ml) and moderately resistant to voriconazole (1 µg/ml) always produced a homogeneous population of resistant cells. Upon maintenance on drug-free medium, however, the majority of the homogeneously resistant cells of these subclones lost their resistance and returned to the stable initial heteroresistant phenotype. The pattern of heteroresistance was not affected by the pH or osmolarity of the medium but was influenced by temperature. The resistance appeared to be suppressed at 35°C and was completely abolished at 40°C. Although heterogeneity in azole resistance among subpopulations of single isolates has been reported for Candida sp., the transient changes in expression of resistance under different growth conditions reported here have not been observed in fungal pathogens.
KW  - acquired immune deficiency syndrome
KW  - antifungal agents
KW  - azoles
KW  - central nervous system
KW  - clones
KW  - cryptococcal meningitis
KW  - cryptococcosis
KW  - drug resistance
KW  - fluconazole
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - meningitis
KW  - opportunistic infections
KW  - phenotypes
KW  - temperature
KW  - voriconazole
KW  - Cryptococcus neoformans
KW  - man
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - AIDS
KW  - CNS
KW  - european blastomycosis
KW  - fungistats
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - meningeal cryptococcosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202460&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Antifungal activity of LY303366, a novel echinocandin B, in experimental disseminated candidiasis in rabbits.
AU  - Petraitiene, R.
AU  - Petraitis, V.
AU  - Groll, A. H.
AU  - Candelario, M.
AU  - Sein, T.
AU  - Bell, A.
AU  - Lyman, C. A.
AU  - McMillian, C. L.
AU  - Bacher, J.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 9
SP  - 2148
EP  - 2155
SN  - 0066-4804
AD  - Petraitiene, R.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991203052.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 1397-89-3, 86386-73-4, 7440-09-7.  Subject Subsets: Medical & Veterinary Mycology
N2  - The safety and antifungal activity of LY303366 (LY), a new broad-spectrum semisynthetic echinocandin, were studied against disseminated candidosis in persistently neutropenic rabbits. In vitro time-kill assays demonstrated that LY has concentration-dependent fungicidal activity. The pharmacokinetics of LY in the plasma of non-neutropenic rabbits suggested a linear relationship between dose and area under the curve (AUC). The times spent above the minimum inhibitory concentration (MIC) during the experimental dosing interval of 24 h were 4 h for LY at 0.1 mg/kg of body weight/day (LY0.1), 8 h for LY at 0.25 mg/kg daily (LY0.25), 12 h for LY at 0.5 mg/kg daily (LY0.5), and 20 h for LY at 1 mg/kg daily (LY1). Antifungal therapy was administered to infected rabbits for 10 days starting 24 h after the intravenous (i.v.) inoculation of 10³Candida albicans blastoconidia. Study groups consisted of untreated controls (UCs) and animals treated with amphotericin B (AmB; 1 mg/kg daily i.v.), fluconazole (FLU; 10 mg/kg daily i.v.) and LY0.1, LY0.25, LY0.5 or LY1 i.v. Rabbits treated with LY0.5, LY1, AmB and FLU had similarly significant clearance of C. albicans from the liver, spleen, kidney, lung, vena cava and brain in comparison to that for UCs. There was a dose-dependent clearance of C. albicans from tissues in response to LY. Among rabbits treated with LY0.1 there was a significant reduction of C. albicans only in the spleen. In animals treated with LY0.25 there was a significant reduction in all tissues but the brain. By comparison, LY0.5 and LY1 cleared all tissues, including the brain, of C. albicans. These in vivo findings were consistent with the results of in vitro time-kill assays. A dose-dependent effect of altered cell wall morphology was observed among UCs and animals treated with LY0.1, and LY0.25, with a progressive transition from hyphal structure to disrupted yeast forms. Serum creatinine levels were higher and serum potassium levels were lower in AmB-treated rabbits than in UCs and LY- and FLU-treated rabbits. LY0.5 and LY1 were well tolerated, displayed predictable pharmacokinetics in plasma, and had activities comparable to those of AmB and FLU in the treatment of disseminated candidosis in persistently neutropenic rabbits.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - blood plasma
KW  - candidosis
KW  - cell walls
KW  - disseminated infections
KW  - drug therapy
KW  - echinocandins
KW  - experimental infections
KW  - fluconazole
KW  - in vitro
KW  - infections
KW  - inoculation
KW  - liver
KW  - lungs
KW  - pharmacokinetics
KW  - potassium
KW  - safety
KW  - spleen
KW  - yeasts
KW  - Candida
KW  - Candida albicans
KW  - rabbits
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - Candida
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - anti-fungal properties
KW  - candidiasis
KW  - chemotherapy
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - LY303366
KW  - plasma (blood)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of the hematoregulatory peptide SK&F 107647 alone and in combination with amphotericin B against disseminated candidiasis in persistently neutropenic rabbits.
AU  - Lyman, C. A.
AU  - Gonzalez, C.
AU  - Schneider, M.
AU  - Lee, J.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 9
SP  - 2165
EP  - 2169
SN  - 0066-4804
AD  - Lyman, C. A.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991203053.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - The effects of SK&F 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidosis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. In healthy animals, SK&F 107647 elicited a time-dependent increase in CD11b-positive monocytes and neutrophils. When administered to neutropenic rabbits infected with Candida albicans, no significant differences in the number of colony forming units (CFU)/g in any of the tissues tested compared with the number in untreated control rabbits were detected. However, when SK&F 107647 was administered in combination with low doses of amphotericin B, there was a significant reduction in organism burden in the lungs, liver, spleen and kidneys compared with the burdens in the organs of untreated control animals and in the lungs and kidneys compared with the burdens in the lungs and kidneys of animals treated with amphotericin B alone. The results suggested a potential role for this peptide as adjunctive therapy in combination with conventional antifungal agents in the treatment of disseminated candidosis in the setting of profound and persistent neutropenia.
KW  - amphotericin B
KW  - antifungal agents
KW  - antifungal properties
KW  - candidosis
KW  - disseminated infections
KW  - drug therapy
KW  - experimental infections
KW  - infections
KW  - neutropenia
KW  - neutrophils
KW  - spleen
KW  - Candida
KW  - Candida albicans
KW  - rabbits
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - anti-fungal properties
KW  - candidiasis
KW  - chemotherapy
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - SK&F 107647
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991203053&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization.
AU  - Xu YanYing
AU  - Ambudkar, I.
AU  - Yamagishi, H.
AU  - Swaim, W.
AU  - Walsh, T. J.
AU  - O'Connell, B. C.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 9
SP  - 2256
EP  - 2262
SN  - 0066-4804
AD  - Xu YanYing: Gene Therapy and Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991203056.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Radiolabelled histatin 3, was used to show that the protein binds to C. albicans spheroplasts in a manner that is dependent on time and concentration. Binding to the spheroplasts was saturable and could be competed with unlabelled histatin 3. A single histatin 3 binding site with a Kd=5.1 µM was detected. Histatin 3 binding resulted in potassium and magnesium efflux, predominantly within the first 30 min of incubation. Studies with fluorescent histatin 3 demonstrate that the protein is internalized by C. albicans and that translocation of histatin inside the cell is closely associated with cell death. Histatin binding, internalization, and cell death were accelerated in low-ionic-strength conditions. A low extracellular salt concentration was essential for cell death to occur, even when histatin 3 was already bound to the cell. The interaction of histatin 3 with C. albicans, and subsequent cell death, was inhibited at low temperature. These results demonstrate that the candidacidal activity of histatin 3 is not due exclusively to binding at the cell surface but also involves subsequent interactions with the cell.
KW  - antifungal agents
KW  - antifungal properties
KW  - in vitro
KW  - proteins
KW  - saliva
KW  - temperature
KW  - Candida
KW  - Candida albicans
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - anti-fungal properties
KW  - fungicidal properties
KW  - fungistats
KW  - fungus
KW  - histatins
KW  - histidine-rich proteins
KW  - Hyphomycetes
KW  - salivary secretions
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991203056&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pharmacokinetics and safety of high-dose and extended-interval regimens of levofloxacin in human immunodeficiency virus-infected patients.
AU  - Piscitelli, S. C.
AU  - Spooner, K.
AU  - Baird, B.
AU  - Chow, A. T.
AU  - Fowler, C. L.
AU  - Williams, R. R.
AU  - Jaya Natarajan
AU  - Masur, H.
AU  - Walker, R. E.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 9
SP  - 2323
EP  - 2327
SN  - 0066-4804
AD  - Piscitelli, S. C.: Bldg. 10, Rm. 11C103, National Institutes of Health, 10 Center Dr. MSC 1880, Bethesda, MD 20892-1880, USA.
N1  - Accession Number: 19992012601.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Registry Number: 100986-85-4. 
N2  - The pharmacokinetics of levofloxacin, administered in high doses and with extended dosing intervals, was studied in human immunodeficiency virus (HIV)-infected patients. 30 patients received either 750 mg of the drug or a placebo once daily for 14 days, followed by 750 mg or 1000 mg of the drug or a placebo 3 times weekly for an additional 14 days. Levofloxacin disposition was characterized by rapid oral absorption, with peak concentrations occurring approximately 1.5 h after dosing and elimination half-lives from 7.2 to 9.4 h. The overall incidence of any adverse effect was 70% (1000 mg) to 95% (750 mg) for levofloxacin-treated patients and 71% for those taking the placebo. Levofloxacin pharmacokinetic parameters for HIV-infected patients were consistent with those observed in studies of healthy volunteers.
KW  - antibacterial agents
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - levofloxacin
KW  - pharmacokinetics
KW  - regimens
KW  - safety
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits.
AU  - Groll, A. H.
AU  - Petraitis, V.
AU  - Petraitiene, R.
AU  - Field-Ridley, A.
AU  - Calendario, M.
AU  - Bacher, J.
AU  - Piscitelli, S. C.
AU  - Walsh, T. J.
JO  - Antimicrobial Agents and Chemotherapy
JF  - Antimicrobial Agents and Chemotherapy
Y1  - 1999///
VL  - 43
IS  - 10
SP  - 2463
EP  - 2467
SN  - 0066-4804
AD  - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10, Center Dr., Bethesda, MD 20892, USA.
N1  - Accession Number: 19991203131.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 1397-89-3, 86386-73-4, 1400-61-9.  Subject Subsets: Medical & Veterinary Mycology
N2  - The activity of liposomal nystatin (L-Nys) against subacute disseminated candidosis was investigated in persistently neutropenic rabbits. Antifungal therapy was administered for 10 days starting 24 h after intravenous inoculation of 10³ blastoconidia of Candida albicans. Responses to treatment were assessed by the quantitative clearance of the organism from blood and tissues. Treatments consisted of L-Nys at dosages of 2 and 4 mg/kg daily (L-Nys2 and L-Nys4, respectively) amphotericin B deoxycholate at 1 mg/kg daily (D-AmB) and fluconazole at 10 mg/kg daily (Flu). All treatments were given intravenously once daily. Compared with the results for untreated but infected control animals, treatment with L-Nys2, L-Nys4, D-AmB and Flu resulted in a significant clearance of the residual burden of C. albicans from the kidney, liver, spleen, lung and brain (P&lt;0.0001). When the proportion of animals infected at at least one of the 5 tissue sites studied was evaluated, a dose-dependent response to treatment with L-Nys was found (P&lt;0.05). Compared to D-AmB-treated rabbits, mean serum creatinine and blood urea nitrogen levels at the end of therapy were significantly lower in animals treated with L-Nys2 (P&lt;0.001) and L-Nys4 (P&lt;0.001 and P&lt;0.01, respectively). It is concluded that L-Nys was less nephrotoxic than conventional amphotericin B and had dose-dependent activity comparable to that of amphotericin B for the early treatment of subacute disseminated candidosis in persistently neutropenic rabbits.
KW  - amphotericin B
KW  - antifungal agents
KW  - application methods
KW  - candidosis
KW  - disseminated infections
KW  - drug formulations
KW  - drug therapy
KW  - experimental infections
KW  - fluconazole
KW  - infections
KW  - liposomes
KW  - liver
KW  - lungs
KW  - nephrotoxicity
KW  - nystatin
KW  - Candida albicans
KW  - rabbits
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Leporidae
KW  - Lagomorpha
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - candidiasis
KW  - ceratocide
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolating expressed microsporidial genes using a cDNA subtractive hybridization approach.
AU  - Hayman, J. R.
AU  - Nash, T. E.
A2  - Kaneshiro, E. S.
JO  - Journal of Eukaryotic Microbiology
JF  - Journal of Eukaryotic Microbiology
Y1  - 1999///
VL  - 46
IS  - 5
SP  - 21S
EP  - 24S
SN  - 1066-5234
AD  - Hayman, J. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892, USA.
N1  - Accession Number: 20000804607.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 7 ref. Registry Number: 9064-37-3.  Subject Subsets: Protozoology
N2  - Genes expressed by Encephalitozoon intestinalis during the invasion of host cells were identified by taking total messenger RNA (mRNA) and using complementary DNA (cDNA) subtractive hybridization to remove some sequences common to the host and parasite, leaving a higher proportion of sequences unique to the parasite. A number of sequences were cloned and sequenced, and 3 clones were found to have significant similarity to different regions of actin from different species. Further tests confirmed that they were of parasite origin. The full length predicted amino acid sequence of the combined clones was compared with known partial sequences of actin genes from E. hellem, Vairimorpha necatrix and Nosema locustae, and found to be 96%, 79% and 74% identical, respectively. It is concluded that the cDNA subtraction method is effective in isolating expressed microsporidial genes.
KW  - actin
KW  - amino acid sequences
KW  - cell invasion
KW  - complementary DNA
KW  - genes
KW  - messenger RNA
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - techniques
KW  - Encephalitozoon intestinalis
KW  - protozoa
KW  - Encephalitozoon
KW  - Encephalitozoonidae
KW  - Microspora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - cDNA
KW  - DNA sequences
KW  - mRNA
KW  - protein sequences
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.
AU  - Schrauwen, P.
AU  - Xia
AU  - Bogardus, C.
AU  - Pratley, R. E.
AU  - Ravussin, E.
JO  - Diabetes (New York)
JF  - Diabetes (New York)
Y1  - 1999///
VL  - 48
IS  - 1
SP  - 146
EP  - 149
SN  - 0012-1797
AD  - Schrauwen, P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
N1  - Accession Number: 19991409009.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Human Nutrition
N2  - The recent discovery of uncoupling protein (UCP)-2 and UCP-3, and their high expression in skeletal muscle, has renewed interest in a possible role for these proteins in underlying the variability in energy expenditure and therefore metabolic efficiency. Using reverse transcription-polymerase chain reaction, levels of expression of UCP-2 and long and short forms of UCP-3 were measured in skeletal muscle of 19 nondiabetic, male Pima Indians covering a wide range of body weight. 24-h energy expenditure was measured in a respiratory chamber in 16 of these individuals. BMI was negatively correlated with the expression levels of the long (r=-0.53, P=0.025) and short (r=-0.46, P=0.047) forms of UCP-3. BMI was not correlated with UCP-2 expression. Metabolic rate during sleep, adjusted for fat-free mass and fat mass, was positively correlated with the long form of UCP-3 (r=0.69, P=0.006). These results indicate that UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians.
KW  - American indians
KW  - energy metabolism
KW  - ethnic groups
KW  - gene expression
KW  - skeletal muscle
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - uncoupling protein
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Structure (UU480) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Hypothalamic-pituitary-adrenal axis and sympathetic nervous system activities in Pima Indians and Caucasians.
AU  - Tataranni, P. A.
AU  - Cizza, G.
AU  - Snitker, S.
AU  - Gucciardo, F.
AU  - Lotsikas, A.
AU  - Chrousos, G. P.
AU  - Ravussin, E.
JO  - Metabolism, Clinical and Experimental
JF  - Metabolism, Clinical and Experimental
Y1  - 1999///
VL  - 48
IS  - 3
SP  - 395
EP  - 399
SN  - 0026-0495
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Phoenix, Arizona, USA.
N1  - Accession Number: 19991406784.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 9002-60-2, 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1.  Subject Subsets: Human Nutrition
N2  - It was hypothesized that hypercortisolism and low sympathetic nervous system (SNS) activity may be found in association in Pima Indians, a population with a high prevalence of obesity. Indices of hypothalamic-pituitary-adrenal (HPA) axis and SNS activities were measured in 39 nondiabetic men, 20 Pima Indians (age, 30±5 years; weight, 94±26 kg; 35±8% body fat (mean ± SD)) and 19 Caucasians (33±9 years, 91±23 kg, 28±11% body fat). HPA axis activity was assessed by measurements of morning fasting plasma corticotropin (ACTH) and cortisol concentrations and 24-h urinary free cortisol (UFC) excretion. SNS activity was assessed as muscle sympathetic nerve activity (MSNA) by microneurography and by measurement of catecholamines (fasting plasma concentration and 24-h urinary excretion). Plasma ACTH and cortisol and UFC were similar in Pima Indians and Caucasians. MSNA was positively correlated with percent body fat (r=0.49, P=0.002) and was lower in Pima Indians compared with Caucasians after adjustment for percent body fat (24±9 vs. 31±10 bursts/min, P=0.04). It is concluded that Pima Indians, a population with a high prevalence of obesity, have lower SNS activity but normal HPA axis activity compared with Caucasians.
KW  - adrenal glands
KW  - body fat
KW  - catecholamines
KW  - corticotropin
KW  - ethnic groups
KW  - hydrocortisone
KW  - hypothalamus
KW  - obesity
KW  - pituitary
KW  - sympathetic nervous system
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACTH
KW  - adrenals
KW  - adrenocorticotropic hormone
KW  - adrenocorticotropin
KW  - cortisol
KW  - fatness
KW  - hypophysis
KW  - pituitary gland
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Interrelationships of spontaneous growth hormone axis activity, body fat, and serum lipids in healthy elderly women and men.
AU  - O'Connor, K. G.
AU  - Harman, S. M.
AU  - Stevens, T. E.
AU  - Jayme, J. J.
AU  - Bellantoni, M. F.
AU  - Busby-Whitehead, M. J.
AU  - Christmas, C.
AU  - Münzer, T.
AU  - Tobin, J. D.
AU  - Roy, T. A.
AU  - Cottrell, E.
AU  - St. Clair, C.
AU  - Pabst, K. M.
AU  - Blackman, M. R.
JO  - Metabolism, Clinical and Experimental
JF  - Metabolism, Clinical and Experimental
Y1  - 1999///
VL  - 48
IS  - 11
SP  - 1424
EP  - 1431
SN  - 0026-0495
AD  - O'Connor, K. G.: Endocrine and Applied Physiology Sections, Gerontology Research Center, National Institute on Aging, National Institutes of Health (NIH), Baltimore, MD, USA.
N1  - Accession Number: 20001408199.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 57-88-5, 61912-98-9, 9002-72-6.  Subject Subsets: Human Nutrition
N2  - The relation between growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis function and lipid profile was examined by evaluating GH secretion, serum IGF-I and IGF binding protein-3 (IGFBP-3) levels, adiposity via the body mass index (BMI), waist to hip ratio (WHR), dual-energy x-ray absorptiometry (DEXA), and magnetic resonance imaging (MRI), and circulating lipids in 101 healthy subjects older than 65 years at John Hopkins Bayview Medical Centre, Maryland, USA [date not given]. Integrated nocturnal GH secretion (log IAUPGH) was inversely related (P &lt; 0.005) to DEXA total and abdominal fat and MRI visceral fat in both genders. Log IAUPGH was inversely related to visceral fat in women (P &lt; 0.005) and men (P &lt; 0.0001), but was not significantly related to total fat in either gender. In women, log IAUPGH was related inversely to total and LDL cholesterol and positively to HDL cholesterol (P &lt; 0.008). In men, log IAUPGH was inversely related to total cholesterol and triglycerides (P &lt; 0.005). In women, HDL cholesterol was inversely related to the WHR (P &lt; 0.005). In men, triglycerides were positively related (P ,less than 0.001) to the WHR and DEXA abdominal and MRI visceral fat. Multivariate regression revealed log IAUPGH, but not DEXA total body fat, to be an independent determinant of total (P &lt; 0.001 for women and P = 0.01 for men) and LDL (P &lt; 0.007 and P = 0.05) cholesterol in both sexes and of HDL cholesterol (P &lt; 0.005) and triglycerides (P &lt; 0.03) in women. Log IAUPGH, but not DEXA abdominal fat, was related to total (P &lt; 0.005 and P &lt; 0.03) and LDL (P &lt; 0.03 and P = 0.05) cholesterol in both genders and to HDL in women (P &lt; 0.05). Log IAUPGH, but not MRI visceral fat, was related to total cholesterol (P &lt; 0.03 and P = 0.05) in women and men. Age, IGF, and IGFBP-3 were not significantly related to any body fat or lipid measures, except for a positive correlation of IGF-I with triglycerides in men. It is concluded that the endogenous nocturnal GH secretion predicts total, LDL, and HDL cholesterol levels independently of total or abdominal fat, suggesting that it is an independent cardiometabolic risk factor in healthy elderly people.
KW  - blood lipids
KW  - blood serum
KW  - body fat
KW  - body mass index
KW  - cholesterol
KW  - elderly
KW  - high density lipoprotein
KW  - human diseases
KW  - insulin-like growth factor
KW  - lipids
KW  - low density lipoprotein
KW  - magnetic resonance imaging
KW  - old age
KW  - risk factors
KW  - sex differences
KW  - somatotropin
KW  - triacylglycerols
KW  - Maryland
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aged
KW  - elderly people
KW  - growth hormone
KW  - lipins
KW  - older adults
KW  - senior citizens
KW  - somatomedin C
KW  - triglycerides
KW  - United States of America
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Management of a measles outbreak among Old World nonhuman primates.
AU  - Willy, M. E.
AU  - Woodward, R. A.
AU  - Thornton, V. B.
AU  - Wolff, A. V.
AU  - Flynn, B. M.
AU  - Heath, J. L.
AU  - Villamarzo, Y. S.
AU  - Smith, S.
AU  - Bellini, W. J.
AU  - Rota, P. A.
JO  - Laboratory Animal Science
JF  - Laboratory Animal Science
Y1  - 1999///
VL  - 49
IS  - 1
SP  - 42
EP  - 48
SN  - 0023-6764
AD  - Willy, M. E.: Hospital Epidemiology Service, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992207325.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2  - A measles outbreak occurred in a US facility housing primates (including Macaca mulatta, M. fascicularis and M. nemestrina) in 1996. Serum and urine specimens were collected from monkeys housed in the room where the initial measles cases were identified, other monkeys with suspicious measles-like signs, and employees working in the affected areas. Serum specimens were tested for measles virus-specific IgG and IgM antibodies, and urine specimens were tested for measles virus by virus isolation or reverse transcriptase-polymerase chain reaction. 94 monkeys in 2 separate facilities had evidence of an acute measles infection. The outbreak was caused by a wild-type virus that had been associated with recent human cases of acute measles in the USA; however, an investigation was unable to identify the original source of the outbreak. Quarantine and massive vaccination helped to control further spread of infection.
KW  - disease control
KW  - introduced species
KW  - laboratory animals
KW  - outbreaks
KW  - quarantine
KW  - vaccination
KW  - viral diseases
KW  - zoonoses
KW  - Maryland
KW  - USA
KW  - Macaca fascicularis
KW  - Macaca mulatta
KW  - Macaca nemestrina
KW  - man
KW  - measles virus
KW  - monkeys
KW  - Morbillivirus
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Morbillivirus
KW  - Paramyxovirinae
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - exotic organisms
KW  - exotic species
KW  - introduced organisms
KW  - non-indigenous organisms
KW  - non-indigenous species
KW  - non-native organisms
KW  - non-native species
KW  - nonindigenous organisms
KW  - nonindigenous species
KW  - United States of America
KW  - viral infections
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Laboratory Animal Science (LL040) 
KW  - Pathogen, Pest, Parasite and Weed Management (General) (HH000) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clinicopathological features and management of Pakistani patients with multiple myeloma.
AU  - Hina Shaheen
AU  - Imran Ghanghroo
AU  - Imtiaz Malik
JO  - Journal of the Pakistan Medical Association
JF  - Journal of the Pakistan Medical Association
Y1  - 1999///
VL  - 49
IS  - 10
SP  - 233
EP  - 237
SN  - 0030-9982
AD  - Hina Shaheen: National Cancer Institute and Research Center, Karachi, Pakistan.
N1  - Accession Number: 20002009856.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Registry Number: 50-24-8, 5060-55-9, 52-21-1, 630-67-1, 1107-99-9, 125-02-0.  Subject Subsets: Tropical Diseases
N2  - A retrospective analysis was conducted of 99 newly diagnosed patients with multiple myeloma seen during 1988-96 in Pakistan. Diagnostic criteria included bone marrow plasmacytosis, monoclonal gammopathy in serum or urine and radiological evidence of skeletal lesions. There were 57 males and 42 females. Mean age of the patients was 58 years, range 23-86 years. One-third of the patients were bed-ridden at the time of presentation. Common presenting symptoms included bone pain (82%), fatigue (78%) and backache (73%). Physical findings, laboratory features and radiological assessment revealed pallor (56%), severe anaemia with haemoglobin &lt;8.5 gm/dl (39%), creatinine ≥2 2 mg/dl (57%), serum calcium ≥12 gm/dl (23%), uric acid ≥8 gm/dl (47%) and albumin≤3.5 gm/dl (63%). The most common monoclonal gammopathy was IgG kappa. 71% of the patients presented with stage III disease. The most common chemotherapeutic regimen utilized was melphalan and prednisolone which was administered to 88% of the patients. Complete remission was observed in 25% and partial remission in 36% of the evaluated patients. Commonest complication during the course of disease was related to skeletal involvement followed by renal failure and bone marrow suppression. Median survival of the patients was 34 months. It is concluded that multiple myeloma patients in Pakistan are younger, more frequently have poor performance status and more often present with advanced stage of disease. Response to therapy, however, is adequate and survival is comparable to Western patients.
KW  - clinical aspects
KW  - complications
KW  - diagnosis
KW  - drug therapy
KW  - human diseases
KW  - myeloma
KW  - pathology
KW  - prednisolone
KW  - prognosis
KW  - survival
KW  - Pakistan
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - chemotherapy
KW  - clinical picture
KW  - melphalan
KW  - multiple myeloma
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 
TY  - JOUR
T1  - Hypericum perforatum extracts as potential antidepressants.
AU  - Vitiello, B.
JO  - Journal of Pharmacy and Pharmacology
JF  - Journal of Pharmacy and Pharmacology
Y1  - 1999///
VL  - 51
IS  - 5
SP  - 513
EP  - 517
SN  - 0022-3573
AD  - Vitiello, B.: National Institute of Mental Health, Room 7147, 6001 Executive Boulevard, Bethesda MD, USA.
N1  - Accession Number: 19990308906.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 20 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Extracts of H. perforatum have been used in the treatment of mild to moderate depression for many years in Europe. More recently, these extracts have become available in the USA as dietary supplements and have been popularly used to improve mood. In support of this practice, data from several controlled clinical studies suggest that H. perforatum is better than placebo and as effective as established antidepressant drugs. These data have, however, several limitations, indicating the need for more research. Extant data on the safety and efficacy of H. perforatum extracts in depression are here critically reviewed and plans for further research presented.
KW  - antidepressants
KW  - clinical trials
KW  - depression
KW  - efficacy
KW  - medicinal plants
KW  - pharmacology
KW  - plant extracts
KW  - reviews
KW  - safety
KW  - treatment
KW  - Europe
KW  - USA
KW  - Hypericum perforatum
KW  - Hypericum
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - drug plants
KW  - medicinal herbs
KW  - officinal plants
KW  - United States of America
KW  - Plant Science (General) (FF000) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Distribution and metabolism of (5-Hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration.
AU  - Godfrey, V. B.
AU  - Chen LingJen
AU  - Griffin, R. J.
AU  - Lebetkin, E. H.
AU  - Burka, L. T.
JO  - Journal of Toxicology and Environmental Health. Part A
JF  - Journal of Toxicology and Environmental Health. Part A
Y1  - 1999///
VL  - 57
IS  - 3
SP  - 199
EP  - 210
AD  - Godfrey, V. B.: Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 19991410211.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 67-47-0.  Subject Subsets: Human Nutrition
N2  - Recent reports have shown (5-Hydroxymethyl)furfural (HMF) to be an in vitro mutagen after sulfate conjugation and to be a promoter as well as a weak initiator of colonic aberrant foci in rats. In order to investigate the metabolic activation further and to provide information for HMF toxicology studies, the disposition of [14C]-HMF was investigated in male F344 rats and B6C3F1 mice following administration of either 5, 10, 100, or 500 mg/kg by gavage. Tissue distribution results indicated that absorption of HMF was rapid in male rats and mice and that tissue concentrations in male mice at the earliest time point were not linearly proportional to dose. Excretion was primarily via the urine in both, with 60-80% of the administered dose excreted by this route in 48 h. Tissue/blood ratios of HMF-derived radioactivity were greater than 1 for liver and kidney. Three metabolites were identified and quantitated in urine. Formation of one of the metabolites, N-(5-hydroxy-methyl-2-furoyl)glycine, was inversely proportional to dose in rats but not mice. None of the metabolites were sulfate conjugates nor likely to be formed from sulfate conjugates. There were relatively low levels of non-extractable radioactivity in liver, kidney, and intestines, indicating that some reactive intermediate(s) may be formed.
KW  - blood
KW  - excretion
KW  - HMF
KW  - kidneys
KW  - liver
KW  - Maillard reaction
KW  - metabolism
KW  - metabolites
KW  - mutagens
KW  - tissues
KW  - toxicity
KW  - toxicology
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - hydroxymethylfurfural
KW  - non-enzymatic browning
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Type 2 diabetes among the Pima Indians of Arizona: an epidemic attributable to environmental change?
AU  - Bennett, P. H.
A2  - Arroyo, P.
A2  - Bourges, H.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1999///
VL  - 57
IS  - 5, II
SP  - S51
EP  - S54
SN  - 0029-6643
AD  - Bennett, P. H.: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, Arizona 85014, USA.
N1  - Accession Number: 19991410682.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 17 ref. Subject Subsets: Human Nutrition
N2  - The history of diabetes in the Pima Indians of Arizona, USA, is described and risk factors are discussed, including genetic factors, obesity, physical activity, bottle feeding of infants, low birth weight and maternal factors. It is considered that diabetes in this group is a clear example of genetic-environmental interaction, genetic susceptibility being a prerequisite for the development of the disease and exposure to adverse environmental factors being essential for its appearance.
KW  - birth weight
KW  - diabetes mellitus
KW  - environment
KW  - ethnic groups
KW  - genetic factors
KW  - infant feeding
KW  - infants
KW  - obesity
KW  - physical activity
KW  - risk factors
KW  - Arizona
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mountain States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Southwestern States of USA
KW  - fatness
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in breast milk from two cities in Ukraine.
AU  - Gladen, B. C.
AU  - Schecter, A. J.
AU  - Päpke, O.
AU  - Shkyryak-Nyzhnyk, Z. A.
AU  - Hryhorczuk, D. O.
AU  - Little, R. E.
JO  - Journal of Toxicology and Environmental Health. Part A
JF  - Journal of Toxicology and Environmental Health. Part A
Y1  - 1999///
VL  - 58
IS  - 3
SP  - 119
EP  - 127
AD  - Gladen, B. C.: Biostatistics Branch, Mail Drop A3-03, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19990405266.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Dairy Science; Human Nutrition
N2  - A study was carried out to determine polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF) and coplanar polychlorinated biphenyls (PCB) in human milk in the Ukraine. Samples of milk were obtained from 200 women from the cities of Kyiv and Dniprodzerzhinsk. The samples were combined into 4 pools by city and age, and analysed for 7 PCDD, 10 PCDF and 2 coplanar PCB (126 and 169). The total of the measured PCDD, expressed as toxic equivalents, ranged from 5.1 to 7.6 pg/g lipid; for PCDF from 3.6 to 5.2, and for PCB from 11 to 18 pg/g lipid. Results from the 2 cities were similar; older women had slightly higher concentrations than did younger women. Levels of these compounds seen in Ukraine were similar to or lower than those seen in other recent studies from European and Asian countries.
KW  - contamination
KW  - dioxins
KW  - human milk
KW  - pollution
KW  - polychlorinated biphenyls
KW  - polychlorinated dibenzofurans
KW  - women
KW  - Ukraine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - breast milk
KW  - environmental pollution
KW  - PCBs
KW  - Pollution and Degradation (PP600) 
KW  - Milk and Dairy Produce (QQ010) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adeno-associated virus and development of cervical neoplasia.
AU  - Strickler, H. D.
AU  - Viscidi, R.
AU  - Escoffery, C.
AU  - Rattray, C.
AU  - Kotloff, K. L.
AU  - Goldberg, J.
AU  - Manns, A.
AU  - Rabkin, C.
AU  - Daniel, R.
AU  - Hanchard, B.
AU  - Brown, C.
AU  - Hutchinson, M.
AU  - Zanizer, D.
AU  - Palefsky, J.
AU  - Burk, R. D.
AU  - Cranston, B.
AU  - Clayman, B.
AU  - Shah, K. V.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1999///
VL  - 59
IS  - 1
SP  - 60
EP  - 65
SN  - 0146-6615
AD  - Strickler, H. D.: Viral Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
N1  - Accession Number: 19992009795.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9007-49-2.  Subject Subsets: Public Health; Tropical Diseases
N2  - Evidence from several sources has suggested that adeno-associated virus (AAV) infection might protect against cervical cancer, in part, by interfering with human papillomavirus (HPV)-induced tumourigenesis. Detection of AAV type 2 (AAV-2) DNA in cervical tissues has been reported. However, there have been few in vivo studies of women with cervical HPV infection or neoplasia, and these have reported inconsistent results. Polymerase chain reaction (PCR) assays targeted to the AAV-2 rep and cap genes were used to test tissue specimens from women in an epidemiological study of cervical neoplasia in Jamaica. 105 women with low-grade cervical intraepithelial neoplasia (CIN-1), 92 women with CIN-3/carcinoma in situ or invasive cancer (CIN-3/CA), and 94 normal subjects were tested. PCR amplification of human β-globin DNA was found in almost all cervical specimens, indicating that these materials were adequate for PCR testing. The prevalence of HPV DNA, determined by HPV L1 consensus primer PCR was, as expected, strongly associated with presence and grade of neoplasia. Each of the AAV PCR assays detected as few as 10 copies of the virus genome. However, none of the 291 cervical specimens from Jamaican subjects tested positive for AAV DNA. Negative AAV PCR results were also obtained in tests of cervical samples from 79 university students in the USA. Exposure to AAV was assessed further by serology. Using a whole virus AAV-2 sandwich enzyme-linked immunosorbent assay, no relationship was found between AAV antibodies and presence or grade of neoplasia in either the Jamaican study subjects or women enrolled in a US cervical cancer case (n=74) -control (n=77) study. Overall, the data provide no evidence that AAV infection plays a role in cervical tumourigenesis or that AAV commonly infects cervical epithelial cells.
KW  - antibodies
KW  - cervical cancer
KW  - cervix
KW  - disease prevention
KW  - DNA
KW  - epidemiology
KW  - genes
KW  - genomes
KW  - human diseases
KW  - neoplasms
KW  - pathogenesis
KW  - protection
KW  - serology
KW  - women
KW  - Jamaica
KW  - adeno-associated virus
KW  - human papillomaviruses
KW  - man
KW  - Parvoviridae
KW  - ssDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - Papillomaviridae
KW  - cancers
KW  - deoxyribonucleic acid
KW  - human papillomavirus
KW  - Papovaviridae
KW  - Techniques and Methodology (ZZ900) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells.
AU  - Zhu WeiYong
AU  - Jones, C. S.
AU  - Amin, S.
AU  - Matsukuma, K.
AU  - Haque, M.
AU  - Vuligonda, V.
AU  - Chandraratna, R. A. S.
AU  - Luca, L. M. de
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1999///
VL  - 59
IS  - 1
SP  - 85
EP  - 90
SN  - 0008-5472
AD  - Zhu WeiYong: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892-4255, USA.
N1  - Accession Number: 19991403261.  Publication Type: Journal Article.  Language: English.  Number of References: 43 ref. Registry Number: 302-79-4.  Subject Subsets: Human Nutrition
N2  - Treatment of oestrogen receptor (ER)-positive MCF-7 human breast cancer cells with retinoic acid (RA) inhibited cell growth and increased cell adhesion to fibronectin. In contrast, ER- MDA-MB-231 cells failed to respond. Western blot analysis showed that tyrosine phosphorylation of two major bands at Mr 125 000 and Mr 68 000 was induced by RA in ER+ MCF-7 human breast carcinoma cells. However, this induction was a late phenomenon detectable at 12 and 24 h, but not within 3 h. A similar increase of tyrosine phosphorylation by RA was observed in ER+ human breast cancer cell lines T-47D and ZR-75-1, but not in the ER- cell lines MDA-MB-231, MDA-MB-453, and MDA-MB-468. Focal adhesion kinase and paxillin, which localize in focal adhesion plaques and may play important roles in the integrin signalling pathway, were identified as the major proteins showing RA-induced tyrosine phosphorylation. The retinoid X receptor-selective compound SR11237 failed to induce tyrosine phosphorylation, indicating that retinoid X receptor activation is not involved in this phenomenon. In contrast, stable overexpression of a truncated RA receptor (RAR) α cDNA, RARα403, with strong RAR dominant negative activity prevented the increase in tyrosine phosphate, suggesting that RAR signalling is involved in RA-induced tyrosine phosphorylation. Tyrosine phosphorylation was induced the most by the RAR-α (193836), followed by RAR-γ (194433), but was not significantly induced by RAR-β (193174)-selective retinoids. This study demonstrates a coordinated albeit relatively late effect of RA on cell adhesion and tyrosine phosphorylation in ER+ human breast cancer cells and suggests RAR-α as the major responsible retinoid receptor.
KW  - adhesion
KW  - breast cancer
KW  - cell cultures
KW  - growth
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - phosphorylation
KW  - receptors
KW  - retinoic acid
KW  - cancers
KW  - fibronectin
KW  - mammary tumour
KW  - tretinoin
KW  - vitamin A acid
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population.
AU  - Meng XiangJin
AU  - Dea, S.
AU  - Engle, R. E.
AU  - Friendship, R.
AU  - Lyoo, Y. S.
AU  - Sirinarumitr, T.
AU  - Urairong, K.
AU  - Wang Dong
AU  - Wong, D.
AU  - Yoo DongWan
AU  - Zhang YanJin
AU  - Purcell, R. H.
AU  - Emerson, S. U.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1999///
VL  - 59
IS  - 3
SP  - 297
EP  - 302
SN  - 0146-6615
AD  - Meng XiangJin: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 19992216200.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2  - To assess the potential of pigs to serve as a global reservoir of hepatitis E virus (HEV), we measured the prevalence of HEV antibodies in pigs in two countries where hepatitis E is endemic (China and Thailand) and two countries where it is not (Korea Republic and Canada). 82 serum samples were taken from pigs in Beijing, China, together with 11 samples from pig handlers and 31 from blood donors. 75 serum samples were taken from pigs from Thailand together with those from 7 pig handlers. 140 serum samples were taken from pigs in Korea Republic. 400 serum samples were taken from pigs in Quebec, Canada, together with 312 serum samples from nursery pigs and a mixture of gilts and sows in Ontario. Swine herds in all 4 countries contained many pigs that were seropositive for IgG anti-HEV, although the percentage of seropositive pigs varied greatly from herd to herd. Most of the pig handlers in the 2 endemic countries were seropositive for HEV. It is suggested that HEV is enzootic in pigs regardless of whether HEV is endemic in the respective human population.
KW  - disease prevalence
KW  - disease surveys
KW  - epidemiology
KW  - horse diseases
KW  - human diseases
KW  - reservoir hosts
KW  - seroprevalence
KW  - viral diseases
KW  - zoonoses
KW  - Beijing
KW  - Canada
KW  - China
KW  - Korea Republic
KW  - Ontario
KW  - Quebec
KW  - Thailand
KW  - hepatitis E virus
KW  - horses
KW  - man
KW  - pigs
KW  - Hepatitis E-like viruses
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Equus
KW  - Equidae
KW  - Perissodactyla
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Sus scrofa
KW  - Sus
KW  - Suidae
KW  - Suiformes
KW  - Artiodactyla
KW  - Northern China
KW  - China
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Threshold Countries
KW  - Canada
KW  - ASEAN Countries
KW  - South East Asia
KW  - animal reservoirs
KW  - disease surveillance
KW  - hogs
KW  - Peking
KW  - People's Republic of China
KW  - South Korea
KW  - swine
KW  - viral infections
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - High prevalence of TT virus (TTV) infection in patients on maintenance hemodialysis: frequent mixed infections with different genotypes and lack of evidence of associated liver disease.
AU  - Forns, X.
AU  - Hegerich, P.
AU  - Darnell, A.
AU  - Emerson, S. U.
AU  - Purcell, R. H.
AU  - Bukh, J.
JO  - Journal of Medical Virology
JF  - Journal of Medical Virology
Y1  - 1999///
VL  - 59
IS  - 3
SP  - 313
EP  - 317
SN  - 0146-6615
AD  - Forns, X.: Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 20002007030.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Registry Number: 9007-49-2. 
N2  - Recently, a novel DNA virus, TT virus (TTV), was identified in patients with post-transfusion non-A-G hepatitis. The authors analysed the prevalence and clinical implications of TTV infection in a cohort of 96 Spanish patients on long-term haemodialysis. TTV DNA was detected by nested PCR in 51 (53%) of 96 patients, a prevalence significantly higher than that found in healthy blood donors. Persistent liver test abnormalities were found in only 2 (7.7%) of 26 patients infected with TTV alone, compared with 12 (75%) of 16 patients infected with hepatitis C or hepatitis B virus, or both (P &lt; 0.01). Mixed infections with multiple strains of TTV, including different major genotypes, were common in patients on haemodialysis. These patients had received a significantly greater number of blood units (22.7 ± 20) compared with patients apparently infected with a single strain of TTV (8.9 ± 11) (P = 0.01). Phylogenetic analyses of TTV from infected patients identified strains of genotypes 1, 2, 3, and 4. In summary, TTV infection was common in patients on haemodialysis but was not associated with liver disease.
KW  - blood donors
KW  - clinical aspects
KW  - disease prevalence
KW  - DNA
KW  - epidemiology
KW  - genotypes
KW  - haemodialysis
KW  - hepatitis B
KW  - hepatitis C
KW  - human diseases
KW  - liver diseases
KW  - mixed infections
KW  - strains
KW  - Spain
KW  - hepatitis B virus
KW  - hepatitis C virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - Circinoviridae
KW  - clinical picture
KW  - deoxyribonucleic acid
KW  - hemodialysis
KW  - multiple infections
KW  - transfusion transmitted virus
KW  - TT virus
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Challenges of and strategies for changing prescribing practices of health care providers.
AU  - Horowitz, A. M.
JO  - Journal of Public Health Dentistry
JF  - Journal of Public Health Dentistry
Y1  - 1999///
VL  - 59
IS  - 4
SP  - 275
EP  - 281
CY  - Portland; USA
PB  - American Association of Public Health Dentistry (AAPHD)
SN  - 0022-4006
AD  - Horowitz, A. M.: Office of Science Policy and Analysis, National Institute of Dental and Craniofacial Research, National Institutes of Health, 45 Center Drive, MSC 6501, 45/3AN-44B, Bethesda, MD 20892-6401, USA.
N1  - Accession Number: 20003006554.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 59 ref. Registry Number: 16984-48-8.  Subject Subsets: Human Nutrition
N2  - Problems related to inappropriate prescribing practices of physicians in general are well recognized. Dietary fluoride supplements have been implicated as one of the contributing factors in an increase in dental fluorosis. Inappropriate prescribing practices of providers have been cited as a major factor in this implication. Numerous studies of physicians and dentists have documented a lack of knowledge and inappropriate prescribing practices regarding fluoride supplements. The purpose of this paper is to identify barriers to changing fluoride-prescribing practices of health care providers and to suggest strategies for implementing change. To increase optimal and appropriate use of fluoride supplements, educational interventions are necessary for all user groups - detail men and women, physicians, dentists, pharmacists, nurse practitioners, dental hygienists, and the public. In addition, environmental supports for the educational activities in the form of policy, regulation, standards of care, and guidelines are recommended for consideration.
KW  - education
KW  - fluoride
KW  - health care workers
KW  - physicians
KW  - prescriptions
KW  - supplements
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - doctors
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-Δ32 mutation.
AU  - Dean, M.
AU  - Jacobson, L. P.
AU  - McFarlane, G.
AU  - Margolick, J. B.
AU  - Jenkins, F. J.
AU  - Howard, O. M. Z.
AU  - Dong HuiFang
AU  - Goedert, J. J.
AU  - Buchbinder, S.
AU  - Gomperts, E.
AU  - Vlahov, D.
AU  - Oppenheim, J. J.
AU  - O'Brien, S. J.
AU  - Carrington, M.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1999///
VL  - 59
IS  - 15
SP  - 3561
EP  - 3564
SN  - 0008-5472
AD  - Dean, M.: Laboratories of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 20002007716.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref.
N2  - Non-Hodgkin's lymphoma (NHL) has been increasing in frequency in the industrialized world, but the environmental and genetic factors that contribute to susceptibility are not known. B-cell lymphomas represent a major cause of morbidity and mortality in HIV-infected individuals. The identification of a deletion in the CCR5 chemokine receptor gene that alters the risk for infection and progression to AIDS led to an examination of the potential role of this gene in AIDS lymphoma. A matched case-control analysis was performed using all eligible NHL cases in the Multicenter AIDS Cohort Study. Patients were matched for age, study center, time AIDS-free, and slope of the CD4+ T-cell decline. The CCR5-Δ32 allele was associated with a 3-fold lower risk of NHL among individuals after controlling for time of infection and progression toward AIDS. The CCR5 gene was not associated with a difference in risk for Kaposi's sarcoma, or opportunistic infections. Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells. Taken together, these findings suggest that the CCR5 gene plays a role in the risk of NHL in HIV-infected patients, perhaps through a mechanism involving a decreased response of B cells to the mitogenic activity of RANTES.
KW  - acquired immune deficiency syndrome
KW  - B lymphocytes
KW  - disease course
KW  - genetics
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - Kaposi's sarcoma
KW  - lymphocyte transformation
KW  - morbidity
KW  - mutations
KW  - non-Hodgkin's lymphoma
KW  - opportunistic infections
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - B cells
KW  - disease progression
KW  - human immunodeficiency virus
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007716&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Retinoid metabolism in the prostate: effects of administration of the synthetic retinoid N -(4-hydroxyphenyl)retinamide.
AU  - Lewis, K. C.
AU  - Hochadel, J. F.
JO  - Cancer Research (Baltimore)
JF  - Cancer Research (Baltimore)
Y1  - 1999///
VL  - 59
IS  - 23
SP  - 5947
EP  - 5955
SN  - 0008-5472
AD  - Lewis, K. C.: Basic Research Laboratory, Division of Basic Sciences [K. C. L.] and Intramural Research Support Program, Science Applications International Corporation-Frederick [J. F. H.] National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 20001411414.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 68-26-8.  Subject Subsets: Human Nutrition
N2  - A series of complementary in vivo and in vitro studies have been carried out to better understand the metabolism of retinol by the prostate gland. Male Sprague-Dawley rats were fed either a control diet sufficient in vitamin A (CON group; 0.8 µg retinol equivalents (RE)/g diet) or a CON diet supplemented with the synthetic retinoid N-(4-hydroxyphenyl)-retinamide (4-HPR; CON plus 4HPR group; 1173 µg of 4-HPR/g diet). After an i.v. injection of a physiological radiolabelled dose of retinol, the retinol content and radioactivity of plasma and a number of tissues, including the prostate glands, were monitored for time periods ranging between 30 min and 41 days. On the basis of the results of these retinol turnover studies, tissue subsystem models were developed to describe retinol dynamics in the prostates of both the CON and CON plus 4HPR groups. There was a gradual decrease in the retinol content of the prostates of the 4-HPR-treated group as compared with the control, such that by the end of the study period, the CON plus 4HPR group averaged 0.166±0.0827 (mean±SD) REs, whereas the CON group was 0.732±0.190 REs. The fraction of retinol exiting the prostate each day was not significantly different in the CON as compared with the CON plus 4HPR group (0.149±0.103 vs 0.155±0.191 h (mean±FSD), respectively); however, the average amount of retinol turning over from the CON plus 4HPR group prostates (0.0885 µg/day) was nearly three times less than that of the CON group (0.243 µg/day). To obtain more detailed information on the mechanisms that might be involved in the changes in retinol kinetics observed in the in vivo studies, both a normal human prostate cell line (PrEC) and a human prostate adenocarcinoma cell line (LNCaP) were used to monitor in vitro retinol and 4-HPR dynamics. Cells were treated with 4-HPR for different time periods up to 48 h (PrEC) or 96 h (LNCaP). Retinol in the media was taken up readily by both PrEC and LNCaP cells, and there was conversion of retinol to the major storage esters of vitamin A, retinyl palmitate and retinyl stearate, as well as several minor retinyl esters, in a pattern indicative of normal retinoid esterification activity. Although 4-HPR was taken up readily and over time accumulated in both cell lines, conversion of 4-HPR to its major metabolite, N-[4-methoxyphenyl]retinamide, as well as several other metabolites of 4-HPR was apparent only in the LNCaP cells. The findings would suggest that a study design that includes appropriately designed complementary in vivo and in vitro experimental systems represents a useful approach to better understanding possible mechanisms involved in basic retinoid functioning and interactions in the prostate as well as in other organs and related tissue culture systems.
KW  - animal models
KW  - cells
KW  - diet
KW  - in vitro
KW  - metabolism
KW  - prostate
KW  - retinol
KW  - retinyl esters
KW  - supplements
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Human Physiology and Biochemistry (VV050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Linkage of a gene causing malaria refractoriness to Diphenol oxidase-A2 on chromosome 3 of Anopheles gambiae.
AU  - Romans, P.
AU  - Black, W. C., IV
AU  - Sakai, R. K.
AU  - Gwadz, R. W.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1999///
VL  - 60
IS  - 1
SP  - 22
EP  - 29
SN  - 0002-9637
AD  - Romans, P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990501643.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Registry Number: 63-84-5, 8049-97-6.  Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - An inbred line of A. gambiae is refractory to development of malaria parasites. It is homozygous for a 4.3-kb Sal I restriction fragment at the Dox-A2 locus, whereas the parent population is polymorphic at this locus, and a susceptible line is homozygous for an alternate 3.85-kb fragment. The Dox-A2 locus is located in the middle of chromosome 3R, in division 33B, and is tightly linked to a cluster of genes including Dopa decarboxylase that are involved in the production of melanin. Because the refractoriness phenotype, melanotic encapsulation of ookinete/oocysts, might involve activation of or alteration in one or more of these genes, the authors performed genetic crosses to determine whether a previously identified Plasmodium cynomolgi strain Ceylon refractoriness gene, Pif-C, is linked to Dox-A2. Backcross mosquitoes fed on one infected monkey (Macaca mulatta) developed infections of ≤100 oocysts. About 50% of these mosquitoes appeared phenotypically refractory, as expected for the backcross performed, but gave slight evidence of linkage between a refractoriness gene and Dox-A2. In contrast, females fed on a monkey that yielded higher infection levels, up to &gt;300 oocysts, showed clear evidence of linkage between a refractoriness gene and Dox-A2. It was concluded that this Dox-A2-linked refractoriness gene is expressed under conditions particular to the higher infection levels, or that environmental factors obscured the genetic effect of this gene at lower infection levels.
KW  - chromosomes
KW  - disease vectors
KW  - DOPA
KW  - genes
KW  - genetics
KW  - inbred lines
KW  - infections
KW  - linkage
KW  - melanins
KW  - oocysts
KW  - parasites
KW  - phenotypes
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Macaca mulatta
KW  - monkeys
KW  - Plasmodium cynomolgi
KW  - protozoa
KW  - Anopheles
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Macaca
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - 3,4-dihydroxyphenylalanine
KW  - diphenol oxidase
KW  - mosquitoes
KW  - pure lines
KW  - refractoriness
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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TY  - JOUR
T1  - Exposure received from application of animal insecticides.
AU  - Stewart, P.
AU  - Fears, T.
AU  - Nicholson, H. F.
AU  - Kross, B. C.
AU  - Ogilvie, L. K.
AU  - Zahm, S. H.
AU  - Ward, M. H.
AU  - Blair, A.
JO  - American Industrial Hygiene Association Journal
JF  - American Industrial Hygiene Association Journal
Y1  - 1999///
VL  - 60
IS  - 2
SP  - 208
EP  - 212
SN  - 0002-8894
AD  - Stewart, P.: Division of Cancer Etiology and Genetics, National Cancer Institute, EPS Room 8102, 6120 Executive Blvd., MSC 7240, Bethesda, MD 20892-7240, USA.
N1  - Accession Number: 19990504374.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 33089-61-1, 2921-88-2, 52-85-7, 55-38-9, 52645-53-1, 732-11-6, 51-03-6.  Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2  - Part of an investigation of data collection methods in epidemiologic studies of farmers evaluated exposures received by farmers from the application of insecticides to animals. 20 farmers were monitored during a normal application using a fluorescent dye surrogate for the active ingredient (AI). Insecticides tested were phosmet, amitraz, piperonyl butoxide, famphur, permethrin, chlorpyrifos and fenthion. Two exposure measures were estimated, AI concentration and the time-weighted average for the application period (TWAa). Four application methods were used: high- (n=5) and low-pressure (n=3) spraying, backpack (n=2) and pour-on (n=10). The 2 farmers using a backpack sprayer had nondetectable levels of dye. Only 2 of the farmers using the pour-on method had detectable dye levels, but these levels were high. All of the low- and high-pressure sprayers had detectable amounts of dye. Multiple layers of clothing, gloves, and boots (n=10) were associated with a low mean AI concentration for the exposed farmers (18 µg) and more than 2-thirds of the farmers wearing this amount of clothing had nondetectable exposures. In contrast, clothing providing little or no protection was associated with a significantly higher (P&lt;0.01) average AI concentration (4420 µg), and less than a third of the farmers with this degree of protection had nondetectable exposures. Poor work practices (leaking equipment, contact with wet animals or fences, and back splash) were associated with statistically higher exposure levels (P&lt;0.01) than the absence of such practices. There was a moderate statistically significant association between AI concentration and TWAa with total volume of the AI/dye/water mixture using the Spearman coefficient. Time was significantly inversely proportional to the 2 exposure measures. The association between the 2 exposure measures and AI volume was not significant.
KW  - amitraz
KW  - application methods
KW  - chlorpyrifos
KW  - clothing
KW  - exposure
KW  - famphur
KW  - farmers
KW  - fenthion
KW  - formamidine insecticides
KW  - livestock
KW  - nontarget effects
KW  - occupational hazards
KW  - organophosphorus insecticides
KW  - permethrin
KW  - phosmet
KW  - piperonyl butoxide
KW  - pour-on formulations
KW  - pyrethroid insecticides
KW  - spraying
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - apparel
KW  - chlorpyrifos-ethyl
KW  - clothes
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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TY  - JOUR
T1  - Long-term persistence of cellular hyporesponsiveness to filarial antigens after clearance of microfilaremia.
AU  - Ramya Gopinath
AU  - Hanna, L. E.
AU  - Kumaraswami, V.
AU  - Pillai, S. V. P.
AU  - Kavitha, V.
AU  - Vijayasekaran, V.
AU  - Rajasekharan, A.
AU  - Nutman, T. B.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1999///
VL  - 60
IS  - 5
SP  - 848
EP  - 853
SN  - 0002-9637
AD  - Ramya Gopinath: Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990805163.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 90-89-1, 1642-54-2, 9008-11-1, 70288-86-7.  Subject Subsets: Helminthology
N2  - The persistence of parasite-specific cellular hyporesponsiveness after clearance of Wuchereria bancrofti blood microfilariae (mff) was studied in 18 individuals in Tamil Nadu, India, who had been treated with a single dose of ivermectin, diethylcarbamazine, or a combination 2-3 years previously and who had initially cleared their parasitaemia. At recruitment into the study, 50% were again mff+ and 50% remained mff-. There were no significant differences between the mff+ and mff- groups in the amount of IFN-γ produced by peripheral blood mononuclear cells in response to adult or microfilarial antigens, although IFN-γ production in response to purified protein derivative was greater in the mff+ group (geometric mean (gm) =3791 pg/ml; P=0.02) than in the mff- group (gm=600 pg/ml). It is suggested that although microfilaraemic individuals may temporarily regain the ability to produce IFN-γ to parasite antigens post-treatment, they subsequently revert to a state of hyporesponsiveness to mff-containing antigens that appears to be independent of the recurrence of microfilaraemia and the response to nonparasite antigens.
KW  - anthelmintics
KW  - diethylcarbamazine
KW  - drug therapy
KW  - helminths
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - ivermectin
KW  - microfilariae
KW  - parasites
KW  - persistence
KW  - India
KW  - Tamil Nadu
KW  - man
KW  - Wuchereria bancrofti
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Wuchereria
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - India
KW  - chemotherapy
KW  - immunity reactions
KW  - immunological reactions
KW  - Madras
KW  - nematodes
KW  - parasitic worms
KW  - Secernentea
KW  - Spirurida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Evidence for widespread infection of wild rats with hepatitis E virus in the United States.
AU  - Kabrane-Lazizi, Y.
AU  - Fine, J. B.
AU  - Elm, J.
AU  - Glass, G. E.
AU  - Higa, H.
AU  - Diwan, A.
AU  - Gibbs, C. J., Jr.
AU  - Meng XiangJin
AU  - Emerson, S. U.
AU  - Purcell, R. H.
JO  - American Journal of Tropical Medicine and Hygiene
JF  - American Journal of Tropical Medicine and Hygiene
Y1  - 1999///
VL  - 61
IS  - 2
SP  - 331
EP  - 335
SN  - 0002-9637
AD  - Kabrane-Lazizi, Y.: Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990506397.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 308067-58-5, 308067-57-4. 
N2  - Hepatitis E is an important medical pathogen in many developing countries but is rarely reported from the USA, although antibody to hepatitis E virus (anti-HEV) is found in &gt;1% of US citizens. Zoonotic spread of the virus is suspected. Sera obtained from 239 wild rats (Rattus norvegicus, R. rattus and R. exulans) trapped in widely separated regions of the USA were tested for anti-HEV. 77% of rats from Maryland (in 1997), 90% from Hawaii (in 1986) and 44% from Louisiana (in 1995) were seropositive for anti-HEV. Rats from urban as well as rural areas were seropositive, and the prevalence of anti-HEV IgG increased in parallel with the estimated age of the rats, leading to speculation that they might be involved in the puzzling high prevalence of anti-HEV among some US city dwellers. The discovery of anti-HEV in rats in the USA and the recently reported discovery that HEV is endemic in US swine raise many questions about transmission, reservoirs and strains of HEV in developed countries.
KW  - antibodies
KW  - epidemiology
KW  - hosts
KW  - IgG
KW  - IgM
KW  - immunoglobulins
KW  - introduced species
KW  - pests
KW  - reservoir hosts
KW  - rural areas
KW  - serological surveys
KW  - small mammals
KW  - urban areas
KW  - wild animals
KW  - zoonoses
KW  - Hawaii
KW  - Louisiana
KW  - Maryland
KW  - USA
KW  - hepatitis E virus
KW  - rats
KW  - Rattus
KW  - Rattus exulans
KW  - Rattus norvegicus
KW  - Rattus rattus
KW  - Hepatitis E-like viruses
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Murinae
KW  - Rattus
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Polynesia
KW  - Oceania
KW  - Pacific Islands
KW  - Delta States of USA
KW  - Southern States of USA
KW  - Gulf States of USA
KW  - West South Central States of USA
KW  - South Atlantic States of USA
KW  - animal reservoirs
KW  - black rat
KW  - brown rat
KW  - exotic organisms
KW  - exotic species
KW  - gamma-globulins
KW  - immune globulins
KW  - introduced organisms
KW  - non-indigenous organisms
KW  - non-indigenous species
KW  - non-native organisms
KW  - non-native species
KW  - nonindigenous organisms
KW  - nonindigenous species
KW  - Norway rat
KW  - seroepidemiology
KW  - ship rat
KW  - United States of America
KW  - vermin
KW  - zoonotic infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Vismiaphenones D-G, new prenylated benzophenones from Vismia cayennensis.
AU  - Fuller, R. W.
AU  - Westergaard, C. K.
AU  - Collins, J. W.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1999///
VL  - 62
IS  - 1
SP  - 67
EP  - 69
SN  - 0163-3864
AD  - Fuller, R. W.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI-FCRDC, Bldg. 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19990302820.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry
N2  - Following anti-HIV [human immunodeficiency virus] bioassay-guided fractionation, 4 new prenylated benzophenones, vismiaphenones D-G, were isolated from extracts of leaves of V. cayennensis (collected from Ecuador). Their structures were elucidated by spectral analyses. Only vismiaphenone D exhibited HIV-inhibitory activity.
KW  - antiviral plants
KW  - antiviral properties
KW  - chemical structure
KW  - fractionation
KW  - human immunodeficiency viruses
KW  - phenolic compounds
KW  - plant composition
KW  - plant extracts
KW  - Ecuador
KW  - plants
KW  - Vismia
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - eukaryotes
KW  - Clusiaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - Vismia
KW  - Andean Group
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - South America
KW  - Threshold Countries
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - human immunodeficiency virus
KW  - Vismia cayennensis
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii.
AU  - Fuller, R. W.
AU  - Blunt, J. W.
AU  - Boswell, J. L.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1999///
VL  - 62
IS  - 1
SP  - 130
EP  - 132
SN  - 0163-3864
AD  - Fuller, R. W.: National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 19990302826.  Publication Type: Journal Article.  Language: English.  Number of References: 12 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry
N2  - Bioassay-guided fractionation of extracts of A. stuhlmannii root wood (collected from Tanzania) led to the isolation of a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F. This compound exhibited HIV [human immunodeficiency virus]-inhibitory activity. Its structure was determined from spectral and chemical data. This is the first report of this compound type in the genus Allanblackia.
KW  - antiviral plants
KW  - antiviral properties
KW  - chemical structure
KW  - fractionation
KW  - human immunodeficiency viruses
KW  - medicinal plants
KW  - plant composition
KW  - plant extracts
KW  - Tanzania
KW  - Clusiaceae
KW  - plants
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Clusiaceae
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - Allanblackia
KW  - Allanblackia stuhlmannii
KW  - anti-viral properties
KW  - chemical constituents of plants
KW  - drug plants
KW  - human immunodeficiency virus
KW  - medicinal herbs
KW  - officinal plants
KW  - Tanganyika
KW  - Forests and Forest Trees (Biology and Ecology) (KK100) 
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - 20-O-β-Glucopyranosyl camptothecin from Mostuea brunonis: a potential camptothecin pro-drug with improved solubility.
AU  - Dai JinRui
AU  - Hallock, Y. F.
AU  - Cardellina, J. H., II
AU  - Boyd, M. R.
JO  - Journal of Natural Products
JF  - Journal of Natural Products
Y1  - 1999///
VL  - 62
IS  - 10
SP  - 1427
EP  - 1429
SN  - 0163-3864
AD  - Dai JinRui: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick Cancer Research & Development Center, Building 1052, Room 121 Frederick, Maryland 21702-1201, USA.
N1  - Accession Number: 20000305167.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2  - Bioassay-guided fractionation of the organic extracts of whole plants of M. brunonis, using the National Cancer Institute's (NCI) human tumour-based in vitro antitumour screen, led to the isolation and identification of camptothecin 20-O-β-D-glucoside and 3 moderately cytotoxic alkaloids, the known deoxypumiloside and strictosamide, and the new 2′-O-acetylstrictosamide, from the cytotoxic alkaloid fractions. While the previously unknown 20-O-β-D-glucopyranosyl camptothecin exhibited greater solubility in alcohol, DMSO-H2O and H2O than camptothecin, it was essentially inactive in the NCI's in vitro 60-cell line primary antitumour screen. However, it could be vulnerable to de-glucosidation in vivo, and may, therefore, merit additional evaluation as a potential prodrug of camptothecin that could be more readily formulated than the parent agent.
KW  - alkaloids
KW  - cell cultures
KW  - cytotoxic compounds
KW  - cytotoxicity
KW  - in vitro
KW  - medicinal plants
KW  - neoplasms
KW  - quinoline alkaloids
KW  - solubility
KW  - Loganiaceae
KW  - man
KW  - Gentianales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Loganiaceae
KW  - cancers
KW  - drug plants
KW  - medicinal herbs
KW  - Mostuea
KW  - Mostuea brunonis
KW  - officinal plants
KW  - Plant Composition (FF040) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - The p47phox-/- mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.
AU  - Segal, B. H.
AU  - Doherty, T. M.
AU  - Wynn, T. A.
AU  - Cheever, A. W.
AU  - Sher, A.
AU  - Holland, S. M.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1999///
VL  - 67
IS  - 4
SP  - 1659
EP  - 1665
SN  - 0019-9567
AD  - Segal, B. H.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, 10 Center Dr., Dr. MSc. 1886, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990803626.  Publication Type: Journal Article.  Language: English.  Number of References: 37 ref. Subject Subsets: Helminthology
N2  - It was hypothesized that abnormal granulomata in patients with chronic granulomatous disease (CGD) may result from aberrant T-cell-mediated cytokine responses. To assess Th-1-type cytokine responses and granulomata, p47phox-/- and wild-type mice were challenged with avirulent (SmD) or virulent (SmT) variants of Mycobacterium avium 2-151. To assess Th-2-type cytokine responses and granulomata, Schistosoma mansoni eggs (SME) were used. Mononuclear cells were harvested, and cytokine responses were determined by ELISA or reverse transcriptase PCR. Following SmD or SmT challenge, splenocytes from p47phox-/- and wild-type mice generated similar polar Th-1 responses (increased levels of interferon-γ and basal levels of IL-4 and IL-5). By 8 weeks after SmT challenge, exuberant splenic granulomata developed in p47phox-/- and wild-type mice. After SME challenge, thoracic lymph node mononuclear cells from p47phox-/- and wild-type mice generated similar mixed Th-1 and Th-2 cytokine responses to SME antigen and concanavalin A. Peak lung granuloma sizes and rates of regression were similar in p47phox-/- and wild-type mice. It is suggested that exuberant granulomatous inflammation in CGD is probably not the result of skewing of T-cell responses toward the Th-1 or Th-2 pole.
KW  - animal models
KW  - cytokines
KW  - disease models
KW  - genetic disorders
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - immune response
KW  - interleukins
KW  - laboratory animals
KW  - lungs
KW  - lymph nodes
KW  - parasites
KW  - T lymphocytes
KW  - mice
KW  - Mycobacterium avium
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacterium
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - bacterium
KW  - chronic granulomatous disease
KW  - genetic defects
KW  - hereditary defects
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803626&site=ehost-live&scope=site
DP  - EBSCOhost
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TY  - JOUR
T1  - Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment.
AU  - Cheever, A. W.
AU  - Poindexter, R. W.
AU  - Wynn, T. A.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1999///
VL  - 67
IS  - 5
SP  - 2201
EP  - 2208
SN  - 0019-9567
AD  - Cheever, A. W.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990804912.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9008-11-1, 207137-56-2, 308079-78-9, 148157-34-0.  Subject Subsets: Helminthology
N2  - Egg laying by Schistosoma mansoni and S. japonicum was delayed in severe combined immunodeficiency (SCID) mice, but in a matter of weeks worm fecundity was equivalent to that in intact mice. SCID mice formed smaller hepatic granulomas and showed less fibrosis than did intact mice. The reduction in egg-associated pathology in SCID mice correlated with marked reductions in IL-4, IL-5, IL-13 and gamma interferon mRNA expression in the liver. S. mansoni infections were frequently lethal for SCID mice infected for more than 9 weeks, whereas S. japonicum-infected SCID mice died at the same rate as infected intact mice. Hepatic granuloma formation and egg laying by worms in SCID mice was unaffected by administration of recombinant murine tumour necrosis factor alpha (TNF-α). In fact, SCID and BALB/c mice appeared to express nearly equivalent levels of TNF-α mRNA in their granulomatous tissues, suggesting that there is little or no deficit in TNF-α expression in infected SCID mice. The data indicate that TNF-α may be in large part derived from a non-T-cell source. Together, these findings provide little evidence that TNF-α alone can reconstitute early fecundity, granuloma formation, or hepatic fibrosis in schistosome-infected SCID mice.
KW  - cytokines
KW  - experimental infections
KW  - fecundity
KW  - helminths
KW  - hepatic fibrosis
KW  - immunocompromised hosts
KW  - immunopathology
KW  - interferon
KW  - interleukin 13
KW  - interleukin 4
KW  - interleukin 5
KW  - laboratory animals
KW  - parasites
KW  - pathology
KW  - SCID mice
KW  - T lymphocytes
KW  - tumour necrosis factor
KW  - mice
KW  - Schistosoma japonicum
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - cachectin
KW  - cachexin
KW  - granulomata
KW  - immunopathogenesis
KW  - parasitic worms
KW  - severe combined immunodeficiency
KW  - Strigeida
KW  - T cells
KW  - tumor necrosis factor
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804912&site=ehost-live&scope=site
DP  - EBSCOhost
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ER  - 

TY  - JOUR
T1  - Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers.
AU  - Kotake, S.
AU  - Schumacher, H. R., Jr.
AU  - Arayssi, T. K.
AU  - Gérard, H. C.
AU  - Branigan, P. J.
AU  - Hudson, A. P.
AU  - Yarboro, C. H.
AU  - Klippel, J. H.
AU  - Wilder, R. L.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1999///
VL  - 67
IS  - 5
SP  - 2682
EP  - 2686
SN  - 0019-9567
AD  - Kotake, S.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992007603.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 9008-11-1, 130068-27-8.  Subject Subsets: Public Health
N2  - The synovial expression of interleukin-10 (IL-10) and gamma interferon (IFN-γ) and additional cytokine genes was examined in patients who had recent-onset Chlamydia-associated arthritis (Chl-AA). IL-10 and IFN-γ mRNA were relatively abundant in recent-onset Chl-AA.
KW  - arthritis
KW  - cytokines
KW  - gene expression
KW  - human diseases
KW  - immune response
KW  - interferon
KW  - interleukin 10
KW  - Chlamydia
KW  - man
KW  - Chlamydiaceae
KW  - Chlamydiales
KW  - Chlamydiae
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - bacterium
KW  - immunity reactions
KW  - immunological reactions
KW  - synovial membranes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007603&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effects of environmental pH on membrane proteins in Borrelia burgdorferi.
AU  - Carroll, J. A.
AU  - Garon, C. F.
AU  - Schwan, T. G.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1999///
VL  - 67
IS  - 7
SP  - 3181
EP  - 3187
SN  - 0019-9567
AD  - Carroll, J. A.: Rocky Mountain Laboratories Microscopy Branch, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
N1  - Accession Number: 20000507029.  Publication Type: Journal Article.  Language: English.  Number of References: 51 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - Borrelia burgdorferi, the causative agent of Lyme disease, alternates between the microenvironments of the tick vector, Ixodes scapularis, and a mammalian host. The environmental conditions the spirochaete encounters during its infectious cycle are suspected to differ greatly in many aspects, including available nutrients, temperature, and pH. Here we identify alterations in the membrane protein profile, as determined by immunoblotting and two-dimensional nonequilibrium pH gradient gel electrophoresis (2D-NEPHGE), that occur in virulent B. burgdorferi B31 as the pH of the medium is altered. Initial comparisons of cultures incubated at pH 6.0, 7.0, and 8.0 yielded alterations in the expression of seven membrane proteins as determined by probing with hyperimmune rabbit serum. Six of these membrane proteins (54, 45, 44, 43, 35, and 24 kDa) were either present in increased amounts in or solely expressed by cultures incubated at pH 6.0 and 7.0. The 24-kDa protein that decreased in expression at pH 8.0 was identified as outer surface protein C (OspC). In addition, a 42-kDa membrane protein increased in amount in cultures incubated at pH 8.0. Similar changes were observed with serum from a mouse infected by tick bite, with the recognition of two additional bands (48 and 46 kDa) unique to pH 6.0 and 7.0. When membrane fractions were analysed by 2D-NEPHGE, at least 37 changes in the membrane protein profile between cells incubated at pH 6.0, 7.0, and 8.0 were observed by immunoblotting and silver staining. Environmental cues such as pH may prove important in the regulation of virulence determinants and factors necessary for the adaptation of B. burgdorferi to the tick or mammalian microcosm.
KW  - human diseases
KW  - in vitro
KW  - Lyme disease
KW  - pH
KW  - surface proteins
KW  - virulence
KW  - Borrelia burgdorferi
KW  - Borrelia
KW  - Spirochaetaceae
KW  - Spirochaetales
KW  - Spirochaetes
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - hydrogen ion concentration
KW  - lyme borreliosis
KW  - membrane proteins
KW  - potential of hydrogen
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Safety and immunogenicity of Vi conjugate vaccines for typhoid fever in adults, teenagers, and 2- to 4-year-old children in Vietnam.
AU  - Kossaczka, Z.
AU  - Lin FengYing
AU  - Vô AnhHo
AU  - Nguyen Thi Thanh Thuy
AU  - Phan Van Bay
AU  - Tran Cong Thanh
AU  - Ha Ba Khiem
AU  - Dang Duc Trach
AU  - Karpas, A.
AU  - Hunt, S.
AU  - Bryla, D. A.
AU  - Schneerson, R.
AU  - Robbins, J. B.
AU  - Szu, S. C.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1999///
VL  - 67
IS  - 11
SP  - 5806
EP  - 5810
SN  - 0019-9567
AD  - Kossaczka, Z.: National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20002008450.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 308067-58-5. 
N2  - The capsular polysaccharide of Salmonella typhi, Vi, is an essential virulence factor and a protective vaccine for people older than 5 years. The safety and immunogenicity of two investigational Vi conjugate vaccines were evaluated in adults, 5- to 14-year-old children, and 2- to 4-year-old children in Vietnam. The conjugates were prepared with Pseudomonas aeruginosa recombinant exoprotein A (rEPA) as the carrier, using either N-succinimidyl-3-(2-pyridyldithio)-propionate (SPDP; Vi-rEPA1) or adipic acid dihydrazide (ADH; Vi-rEPA2) as linkers. None of the recipients experienced a temperature of &gt;38.5°C or significant local reactions. One injection of Vi-rEPA2 into adults elicited a geometric mean (GM) increase in anti-Vi immunoglobulin G (IgG) from 9.62 enzyme-linked immunosorbent assay units/ml (EU) to 465 EU at 6 weeks; this level fell to 119 EU after 26 weeks. In the 5- to 14-year-old children, anti-Vi IgG levels at 6 weeks elicited by Vi-rEPA2, Vi-rEPA1, and Vi were 169, 22.8, and 18.9 EU, respectively (P = 0.0001 for Vi-rEPA1 and Vi with respect to Vi-rEPA2). At 26 weeks, the anti-Vi IgG levels for recipients of Vi-rEPA2, Vi-rEPA1, and Vi were 30.0, 10.8, and 13.4 EU, respectively (P &lt; 0.001 for Vi-rEPA1 and Vi with respect to Vi-rEPA2); all were higher than the preinjection levels (P = 0.0001). Vi-rEPA2 also elicited the highest anti-Vi IgM and IgA levels of the three vaccines. In the 2- to 4-year-old children at 6 weeks following the first injection, Vi-rEPA2 elicited an anti-Vi IgG level of 69.9 EU compared to 28.9 EU for Vi-rEPA1 (P = 0.0001). Reinjection increased Vi antibody levels from 69.9 to 95.4 EU for Vi-rEPA2 and from 28.9 to 83.0 EU for Vi-rEPA1. At 26 weeks, anti-Vi IgG levels remained higher than those at preinjection (30.6 versus 0.18 for Vi-rEPA2 and 12.8 versus 0.33 for Vi-rEPA1; P = 0.0001 for both). Vi vaccine is recommended for individuals of 5 years of age or older. In the present study, the GM level of anti-Vi IgG elicited by two injections of Vi-rEPA2 in the 2- to 4-year-old children was higher than that elicited by Vi in the 5- to 14-year-old children (30.6 versus 13.4; P = 0.0001). The safety and immunogenicity of the Vi-rEPA2 conjugate warrant further investigation.
KW  - adolescents
KW  - adults
KW  - children
KW  - conjugate vaccines
KW  - disease prevention
KW  - human diseases
KW  - IgA
KW  - IgG
KW  - IgM
KW  - immune response
KW  - safety
KW  - typhoid
KW  - Vietnam
KW  - man
KW  - Salmonella typhi
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - Indochina
KW  - South East Asia
KW  - Asia
KW  - bacterium
KW  - immunity reactions
KW  - immunological reactions
KW  - teenagers
KW  - Viet Nam
KW  - Host Resistance and Immunity (HH600) 
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response.
AU  - Cooper, P. J.
AU  - Espinel, I.
AU  - Wieseman, M.
AU  - Paredes, W.
AU  - Espinel, M.
AU  - Guderian, R. H.
AU  - Nutman, T. B.
JO  - Infection and Immunity
JF  - Infection and Immunity
Y1  - 1999///
VL  - 67
IS  - 11
SP  - 5951
EP  - 5957
SN  - 0019-9567
AD  - Cooper, P. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20000804315.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4.  Subject Subsets: Helminthology; Tropical Diseases
N2  - To investigate whether helminth infections may affect the efficacy of vaccines by impairing the immune response to nonparasite vaccine antigens, the antibody responses to tetanus toxoid (TT) after tetanus vaccination in 193 subjects with Onchocerca volvulus infection were compared with those of 85 noninfected controls. After vaccination, the proportions of subjects in each group attaining protective levels of antitetanus antibodies were similar (96.9% infected versus 97.6% noninfected). Postvaccination increases in antitetanus IgG and the predominant IgG isotype (IgG1) were equivalent in both groups, as were increases in specific IgG4 and IgE; however, significantly greater increases in specific IgG2 (P&lt;0.05) and IgG3 (P&lt;0.001) were observed in the noninfected group. Stratification of the O. volvulus-infected group into 2 groups representing light and heavy infections revealed a significantly impaired antitetanus IgG response in those with heavy infections compared to those with light infections (P&lt;0.01) or no infection (P&lt;0.05). The impact of concurrent intestinal helminth infections on the antitetanus response was also examined: an increased IgG4/IgE ratio was seen in those infected with Strongyloides stercoralis (P&lt;0.05) and when all helminth infections were combined as a single group (P&lt;0.05). The results indicate that concurrent infection with O. volvulus does not prevent the development of a protective antitetanus response, although heavier O. volvulus infections are able to alter the magnitude of this response and concurrent helminth infections (O. volvulus and intestinal helminths) may alter TT-specific antibody isotype responses.
KW  - antibodies
KW  - antigens
KW  - helminths
KW  - human diseases
KW  - IgE
KW  - IgG
KW  - immune response
KW  - immunization
KW  - immunoglobulins
KW  - infections
KW  - interactions
KW  - isotypes
KW  - nematode infections
KW  - onchocerciasis
KW  - parasites
KW  - tetanus toxoid
KW  - vaccines
KW  - Clostridium tetani
KW  - man
KW  - Onchocerca volvulus
KW  - Rhabditida
KW  - Strongyloides stercoralis
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - Strongyloides
KW  - Strongyloididae
KW  - antigenicity
KW  - bacterium
KW  - gamma-globulins
KW  - immune globulins
KW  - immune sensitization
KW  - immunity reactions
KW  - immunogens
KW  - immunological reactions
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Photophysical studies on antimalarial drugs.
AU  - Motten, A. G.
AU  - Martínez, L. J.
AU  - Holt, N.
AU  - Sik, R. H.
AU  - Reszka, K.
AU  - Chignell, C. F.
AU  - Tonnesen, H. H.
AU  - Roberts, J. E.
JO  - Photochemistry and Photobiology
JF  - Photochemistry and Photobiology
Y1  - 1999///
VL  - 69
IS  - 3
SP  - 282
EP  - 287
SN  - 0031-8655
AD  - Motten, A. G.: National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
N1  - Accession Number: 19990808168.  Publication Type: Journal Article.  Language: English.  Number of References: 35 ref. Registry Number: 69-44-3, 86-42-0, 50-63-8, 54-05-7, 132-73-0, 64-17-5, 51773-92-3, 53230-10-7, 69-05-6, 82-89-6, 63-45-6, 90-34-6, 549-56-4, 60-93-5, 6119-70-6, 130-89-2, 130-95-0, 118-42-3.  Subject Subsets: Protozoology
N2  - Most drugs used in the treatment of malaria produce phototoxic side effects in both the skin and the eye. Cutaneous and ocular effects that may be caused by light include changes in skin pigmentation, corneal opacity, cataract formation and other visual disturbances including irreversible retinal damage (retinopathy) leading to blindness. The mechanism for these reactions is unknown. A number of antimalarial drugs (amodiaquine, chloroquine, hydroxychloroquine, mefloquine, primaquine and quinacrine) were irradiated with light (λ &gt;300 nm) and electron paramagnetic resonance (EPR) and laser flash photolysis studies were conducted to determine the possible active intermediates produced. Each drug produced at least one EPR adduct with the spintrap 5,5-dimethyl-1-pyrroline N-oxide in benzene: superoxide/hydroperoxyl adducts (chloroquine, mefloquine, quinacrine, amodiaquine and quinine), carbon-centred radical adducts (all but primaquine), or a nitrogen-centred radical adduct only (primaquine). In ethanol all drugs except primaquine produced some superoxide/hydroperoxyl adduct, with quinine, quinacrine and hydroxychloroquine also producing the ethoxyl adduct. As detected with flash photolysis and steady-state techniques, mefloquine, quinine, amodiaquine and a photoproduct of quinacrine produced singlet oxygen (φΔ=0.38; φΔ=0.36; φΔ=0.011; φΔ=0.013 in D2O, pD7), but only primaquine quenched singlet oxygen efficiently (2.6 × 108/M/second in D2O, pD7). Because malaria is most prevalent in regions of high light intensity, protective measures (clothing, sunblock, sunglasses or eye wraps) should be recommended when administering antimalarial drugs.
KW  - adverse effects
KW  - amodiaquine
KW  - antimalarials
KW  - antiprotozoal agents
KW  - blindness
KW  - cataract
KW  - chloroquine
KW  - clothing
KW  - drug toxicity
KW  - ethanol
KW  - eye diseases
KW  - eyes
KW  - human diseases
KW  - hydroxychloroquine
KW  - irradiation
KW  - light
KW  - malaria
KW  - mefloquine
KW  - mepacrine
KW  - parasites
KW  - photolysis
KW  - phototoxicity
KW  - pigmentation
KW  - primaquine
KW  - quinine
KW  - retina
KW  - skin
KW  - man
KW  - Plasmodium
KW  - protozoa
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - adverse reactions
KW  - apparel
KW  - clothes
KW  - dermis
KW  - ethyl alcohol
KW  - photodegradation
KW  - photolytic degradation
KW  - quinacrine
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990808168&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Report of a National Institutes of Health-Centers for Disease Control and Prevention workshop on the feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons.
AU  - Yanovski, S. Z.
AU  - Bain, R. P.
AU  - Williamson, D. F.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 69
IS  - 3
SP  - 366
EP  - 372
SN  - 0002-9165
AD  - Yanovski, S. Z.: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
N1  - Accession Number: 19991404819.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Subject Subsets: Human Nutrition
N2  - The discussions that took place at the workshop are described and it was agreed that a randomised clinical trial could answer questions necessary for developing a rational clinical and public health policy for treating obesity in the USA.
KW  - body weight
KW  - government policy
KW  - health
KW  - health policy
KW  - obesity
KW  - policy
KW  - public health
KW  - weight reduction
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - fatness
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404819&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Causal criteria in nutritional epidemiology.
AU  - Potischman, N.
AU  - Weed, D. L.
A2  - Byers, T.
A2  - Dickson, J. H.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 69
IS  - 6
SP  - 1309S
EP  - 1314S
SN  - 0002-9165
AD  - Potischman, N.: National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19991410527.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 35 ref. Subject Subsets: Human Nutrition
KW  - aetiology
KW  - cardiovascular diseases
KW  - diet
KW  - diet studies
KW  - diet study techniques
KW  - dietary guidelines
KW  - disease prevention
KW  - epidemiology
KW  - methodology
KW  - neoplasms
KW  - prevention
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - methods
KW  - Human Nutrition (General) (VV100) 
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410527&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Food and nutrient exposures: what to consider when evaluating epidemiologic evidence.
AU  - Sempos, C. T.
AU  - Liu Kiang
AU  - Ernst, N. D.
A2  - Byers, T.
A2  - Dickson, J. H.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 69
IS  - 6
SP  - 1330S
EP  - 1338S
SN  - 0002-9165
AD  - Sempos, C. T.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19991410530.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 60 ref. Subject Subsets: Human Nutrition
N2  - An overview of the strengths and limitations of nutritional epidemiology is presented. Study design, dietary survey methodology and interpretation of epidemiologic data and assessment of causality are discussed.
KW  - cardiovascular diseases
KW  - diet
KW  - diet studies
KW  - diet study techniques
KW  - diseases
KW  - epidemiology
KW  - food consumption
KW  - foods
KW  - interpretation
KW  - methodology
KW  - neoplasms
KW  - nutrients
KW  - nutrition
KW  - reviews
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - methods
KW  - Human Nutrition (General) (VV100) 
KW  - Diet Studies (VV110) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410530&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - β-Carotene and lung cancer: a case study.
AU  - Albanes, D.
A2  - Byers, T.
A2  - Dickson, J. H.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 69
IS  - 6
SP  - 1345S
EP  - 1350S
SN  - 0002-9165
AD  - Albanes, D.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19991410689.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 37 ref. Registry Number: 7235-40-7.  Subject Subsets: Human Nutrition
N2  - Available evidence of the relation betweenβ-carotene and lung cancer, including data regarding β-carotene intake (from diet and supplements), β-carotene biochemical status and fruit and vegetable consumption is reviewed. The role of this evidence in making nutrition recommendations is discussed.
KW  - beta-carotene
KW  - carotenoids
KW  - clinical trials
KW  - consumption
KW  - diet
KW  - diet studies
KW  - dietary guidelines
KW  - epidemiology
KW  - fruit
KW  - lung cancer
KW  - lungs
KW  - neoplasms
KW  - reviews
KW  - tobacco smoking
KW  - vegetables
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - tetraterpenoids
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410689&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Energy metabolism in African Americans: potential risk factors for obesity.
AU  - Weyer, C.
AU  - Snitker, S.
AU  - Bogardus, C.
AU  - Ravussin, E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 70
IS  - 1
SP  - 13
EP  - 20
SN  - 0002-9165
AD  - Weyer, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
N1  - Accession Number: 19991411313.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Human Nutrition
N2  - Recent reports have identified a lower resting metabolic rate in African Americans than in whites, but most studies included only females and used short-term measurements with ventilated-hood systems. Our objective was to compare 24-h measurements of energy metabolism between African American and white women and men using a respiratory chamber. 38 African American (x\+- SD: 3\+- 7 years of age, 24±10% body fat) and 288 white (31±7 years of age, 26±12% body fat) subjects spent 24 h in a respiratory chamber for measurement of 24-h energy expenditure (24EE), sleeping metabolic rate (SMR), 24-h respiratory quotient (24RQ), and substrate oxidation rates. After adjustment for sex, age, and body composition (by hydrodensitometry), African Americans had lower SMR (-301±105 kJ/day; P&lt;0.01) and higher 24RQ (0.014±0.004; P&lt;0.001) than whites, whereas 24EE was similar. A sex-specific analysis, using a subset of 38 whites with an equal sex distribution and similar age and body weight, revealed that African American women had lower SMR (-442±182 kJ/day; P&lt;0.05) and lower 24EE (-580±232 kJ/day; P&lt;0.05), but similar 24RQ values compared with white women. African American men tended to have lower SMRs than white men (-355±188 kJ/day; P=0.07), but had higher 24RQ values, accounting for a 992±327-kJ/day lower 24-h fat oxidation rate (P&lt;0.005). These data not only confirm the findings of a lower metabolic rate in African American than in white women, but also suggest that fat oxidation is lower in African American men than in white men.
KW  - basal metabolism
KW  - energy metabolism
KW  - ethnic groups
KW  - men
KW  - metabolism
KW  - respiratory quotient
KW  - resting energy exchange
KW  - sex differences
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - basal energy exchange
KW  - Physiology of Human Nutrition (VV120) 
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411313&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genetic and environmental influences on eating patterns of twins aged ≥50 y.
AU  - Bree, M. B. M. van den
AU  - Eaves, L. J.
AU  - Dwyer, J. T.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 70
IS  - 4
SP  - 456
EP  - 465
SN  - 0002-9165
AD  - Bree, M. B. M. van den: National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, PO Box 5180, Baltimore, MD 21224, USA.
N1  - Accession Number: 20001406231.  Publication Type: Journal Article.  Language: English.  Number of References: 53 ref. Subject Subsets: Human Nutrition
N2  - Male and female twins (n=4640) aged ≥50 years completed a mailed version of the National Cancer Institute food-frequency questionnaire. Factor analysis was performed to identify eating patterns among respondents. Estimates of genetic, common environmental (shared by family members), and specific environmental (unique to an individual) influences were obtained for food use, serving size, and consumption frequency by comparing monozygotic and dizygotic twin-pair groups with structural equation analysis. Two independent eating patterns were identified: the first consisted of items high in fat, salt, and sugar, and the second reflected healthful eating habits. Although the influence of environmental factors was larger, between 15 and 38% of the total variation in pattern 1 and between 33 and 40% in pattern 2 were explained by genetic influences. Models accounting for sex differences in genetic and environmental estimates fit the data significantly better for food use and serving size of foods in eating pattern 1 and for food use in eating pattern 2. It is concluded that although 60-85% of the variability in eating patterns was associated with environmental factors, genetic influences were also apparent and there was some evidence of sex specificity.
KW  - behaviour
KW  - diet
KW  - environmental factors
KW  - feeding behaviour
KW  - foods
KW  - genetics
KW  - nutrients
KW  - old age
KW  - sex differences
KW  - twins
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - behavior
KW  - feeding behavior
KW  - United States of America
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406231&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A-deficient diet.
AU  - Ponnamperuma, R. M.
AU  - Kirchhof, S. M.
AU  - Trifiletti, L.
AU  - Luca, L. M. de
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 70
IS  - 4
SP  - 502
EP  - 508
SN  - 0002-9165
AD  - Ponnamperuma, R. M.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 20001406235.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 302-79-4, 68-26-8.  Subject Subsets: Human Nutrition
N2  - Female SENCAR mice maintained on a purified retinol-deficient diet containing either 0 or 3 µg retinoic acid/g diet were studied. Mice were either ovariectomized or intact. Squamous cells arising in the normally simple columnar epithelium of the endo cervix and uterine cavity were monitored by keratin 5 expression with immunohistochemistry. Ovariectomy did not change the time to onset of retinol deficiency. It increased the number of squamous metaplastic cells and prolonged survival in mice consuming a retinol-deficient diet by as much as 40%. It is concluded that factors other than epithelial differentiation per se control survival outcome of retinol-deficient mice. The results also show a significant increase in longevity of retinol-deficient mice when ovariectomized.
KW  - deficiency
KW  - diet
KW  - epithelium
KW  - longevity
KW  - metaplasia
KW  - mortality
KW  - oestrogens
KW  - ovariectomy
KW  - retinoic acid
KW  - retinoids
KW  - retinol
KW  - steroids
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - death rate
KW  - estrogens
KW  - tretinoin
KW  - vitamin A
KW  - vitamin A acid
KW  - vitamin A alcohol
KW  - vitamin A compounds
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Regions of the human brain affected during a liquid-meal taste perception in the fasting state: a positron emission tomography study.
AU  - Gautier, J. F.
AU  - Chen KeWei
AU  - Uecker, A.
AU  - Bandy, D.
AU  - Frost, J.
AU  - Salbe, A. D.
AU  - Pratley, R. E.
AU  - Lawson, M.
AU  - Ravussin, E.
AU  - Reiman, E. M.
AU  - Tataranni, P. A.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1999///
VL  - 70
IS  - 5
SP  - 806
EP  - 810
SN  - 0002-9165
AD  - Gautier, J. F.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
N1  - Accession Number: 20001407178.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Human Nutrition
N2  - Positron emission tomography (PET) was used to explore regions of the brain that were preferentially affected during the taste perception of a liquid meal by 11 right-handed, lean men in the fasting state. After subjects had fasted for 36 h, 2 measurements of regional cerebral blood flow (rCBF) obtained immediately after subjects retained and swallowed 2 ml of a flavoured liquid meal (the taste condition) were compared with 2 measurements of rCBF obtained immediately after subjects retained and swallowed 2 ml of water (the baseline condition). Taste was associated with increased rCBF (P&lt;0.005) in the left dorsolateral prefrontal cortex and superior temporal gyrus; the right ventrolateral prefrontal cortex, supramarginal gyrus, and anterior thalamus; and bilaterally in the hippocampal formation, posterior cingulate, midbrain, occipital cortex, and cerebellum. Taste was also associated with decreased rCBF (P&lt;0.005) in the right dorsolateral prefrontal cortex, superior temporal gyrus, and supplementary motor area, and bilaterally in the medial prefrontal cortex and inferior parietal lobule. It is concluded that this exploratory study provides additional evidence that the temporal cortex, thalamus, cingulate cortex, caudate, and hippocampal formation are preferentially affected by taste stimulation. The asymmetric pattern of activity in the dorsolateral prefrontal cortex and superior temporal gyrus may contribute to the taste perception of a liquid meal perceived as pleasant. Additional studies are required to determine how these regions are affected in patients with obesity or anorexia.
KW  - blood flow
KW  - brain
KW  - fasting
KW  - men
KW  - perception
KW  - taste
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cerebrum
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Function of a bovine papillomavirus type 1 exonic splicing suppressor requires a suboptimal upstream 3′ splice site.
AU  - Zheng ZhiMing
AU  - He PeiJun
AU  - Baker, C. C.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1999///
VL  - 73
IS  - 1
SP  - 29
EP  - 36
SN  - 0022-538X
AD  - Zheng ZhiMing: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA.
N1  - Accession Number: 19992213135.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Veterinary Science
N2  - Alternative splicing is an important mechanism for the regulation of bovine papillomavirus type 1 (BPV-1) gene expression during the virus life cycle. Previous studies have identified 2 purine-rich exonic splicing enhancers (ESEs), SE1 and SE2, located between 2 alternative 3′ splice sites at nucleotide (nt) 3225 and nt 3605. Further analysis of BPV-1 late-pre-mRNA splicing in vitro identified a 48-nt pyrimidine-rich region immediately downstream of SE1 that inhibits utilization of the nt 3225 3′ splice site. This inhibitory element, named an exonic splicing suppressor (ESS), has a U-rich 5′ end, a C-rich central part, and an AG-rich 3′ end. The present study utilized in vitro splicing of both homologous and heterologous pre-mRNAs to further characterize the ESS. The BPV-1 ESS was inserted downstream of the 3′ splice site in the BPV-1 late pre-mRNA, Rous sarcoma virus src pre-mRNA, human immunodeficiency virus tat-rev pre-mRNA, and Drosophila dsx pre-mRNA, all containing a suboptimal 3′ splice site, and in the human β-globin pre-mRNA, which contains a constitutive 3′ splice site. The results showed that suppression of splicing by the BPV-1 ESS requires an upstream suboptimal 3′ splice site but not an upstream ESE. Furthermore, the ESS functions when located either upstream or downstream of BPV-1 SE1. Mutational analyses showed that the function of the ESS is sequence dependent and that only the C-rich region of the ESS is essential for suppression of splicing in all the pre-mRNAs tested.
KW  - enhancers
KW  - gene expression
KW  - human immunodeficiency viruses
KW  - in vitro
KW  - inhibition
KW  - neoplasms
KW  - nucleotide sequences
KW  - Rous sarcoma
KW  - sarcoma
KW  - splicing
KW  - Drosophila
KW  - Papillomavirus
KW  - Rous sarcoma virus
KW  - viruses
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Drosophilidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Alpharetrovirus
KW  - avian viral sarcoma
KW  - bovine papillomavirus
KW  - cancers
KW  - DNA sequences
KW  - human immunodeficiency virus
KW  - Papovaviridae
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-Communicable Diseases and Injuries of Animals (LL860) 
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a novel simian immunodeficiency virus (SIV) from l'hoest monkeys (Cercopithecus l'hoesti): implications for the origins of SIVmnd and other primate lentiviruses.
AU  - Hirsch, V. M.
AU  - Campbell, B. J.
AU  - Bailes, E.
AU  - Goeken, R.
AU  - Brown, C.
AU  - Elkins, W. R.
AU  - Axthelm, M.
AU  - Murphey-Corb, M.
AU  - Sharp, P. M.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1999///
VL  - 73
IS  - 2
SP  - 1036
EP  - 1045
SN  - 0022-538X
AD  - Hirsch, V. M.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
N1  - Accession Number: 19990505772.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref.
N2  - The human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) appear to have originated by cross-species transmission of simian immunodeficiency virus (SIV) from asymptomatically infected African primates. Few of the SIVs characterized to date efficiently infect human primary lymphocytes. Interesting, 2 of the 3 identified to infect such cultures (SIVsm and SIVcpz) have appeared in human populations as genetically related HIVs. Here, a novel SIV isolate from the East African monkey, C. l'hoesti, which was designated SIVlhoest was characterized. This SIV isolate efficiently infected both human and macaque lymphocytes and resulted in a persistent infection of macaques [Macaca], characterized by high primary virus load and a progressive decline in circulating CD4 lymphocytes, consistent with progression to AIDS. Phylogenetic analyses showed that SIVlhoest is genetically distinct from other previously characterized primate lentiviruses, but clusters in the same major lineage as SIV from mandrills [Mandrillus sphinx] (SIVmnd), a West African primate species. Given the geographic distance between the ranges of l'hoest monkeys and mandrills, this may indicate that SIVmnd arose through cross-species transmission from close relatives of l'hoest monkeys that are sympatric with mandrills. These observations lend support to the hypothesis that the primate lentiviruses originated and coevolved within monkeys of the Cercopithecus genus. Regarded in this light, lentivirus infections of primates not belonging to the Cercopithecus genus may have resulted from cross-species transmission in the not-too-distant past. The EMBL/GenBank/DDBJ accession number for the SIVlhoest nucleotide sequence is AF075269.
KW  - acquired immune deficiency syndrome
KW  - CD4 antigens
KW  - CD4+ lymphocytes
KW  - disease course
KW  - disease transmission
KW  - experimental infections
KW  - lymphocytes
KW  - East Africa
KW  - Cercopithecus
KW  - Lentivirus
KW  - Macaca
KW  - Mandrillus
KW  - Mandrillus sphinx
KW  - monkeys
KW  - Primates
KW  - simian immunodeficiency virus
KW  - Cercopithecidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Lentivirus
KW  - Mandrillus
KW  - Africa South of Sahara
KW  - Africa
KW  - AIDS
KW  - CD4
KW  - CD4+ cells
KW  - Cercopithecinae
KW  - Cercopithecus l'hoesti
KW  - disease progression
KW  - T4 lymphocytes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505772&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence.
AU  - Chabry, J.
AU  - Priola, S. A.
AU  - Wehrly, K.
AU  - Nishio, J.
AU  - Hope, J.
AU  - Chesebro, B.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1999///
VL  - 73
IS  - 8
SP  - 6245
EP  - 6250
SN  - 0022-538X
AD  - Chabry, J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 20002216868.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Veterinary Science
N2  - Conversion of the normal protease-sensitive prion protein (PrP) to its abnormal protease-resistant isoform (PrP-res) is a major feature of the pathogenesis associated with transmissible spongiform encephalopathy (TSE) diseases. In previous experiments, PrP conversion was inhibited by a peptide composed of hamster PrP residues 109 to 141, suggesting that this region of the PrP molecule plays a crucial role in the conversion process. In this study, we used PrP-res derived from animals infected with two different mouse scrapie strains and one hamster scrapie strain to investigate the species specificity of these conversion reactions. Conversion of PrP was found to be completely species specific; however, despite having three amino acid differences, peptides corresponding to the hamster and mouse PrP sequences from residues 109 to 141 inhibited both the mouse and hamster PrP conversion systems equally. Furthermore, a peptide corresponding to hamster PrP residues 119 to 136, which was identical in both mouse and hamster PrP, was able to inhibit PrP-res formation in both the mouse and hamster cell-free systems as well as in scrapie-infected mouse neuroblastoma cell cultures. Because the PrP region from 119 to 136 is very conserved in most species, this peptide may have inhibitory effects on PrP conversion in a wide variety of TSE diseases.
KW  - prion diseases
KW  - prion proteins
KW  - prions
KW  - scrapie
KW  - spongiform encephalopathy
KW  - hamsters
KW  - mice
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002216868&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia.
AU  - Pevenstein, S. R.
AU  - Williams, R. K.
AU  - McChesney, D.
AU  - Mont, E. K.
AU  - Smialek, J. E.
AU  - Straus, S. E.
JO  - Journal of Virology
JF  - Journal of Virology
Y1  - 1999///
VL  - 73
IS  - 12
SP  - 10514
EP  - 10518
SN  - 0022-538X
AD  - Pevenstein, S. R.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Building 10, 11N228, 10 Center Dr., Bethesda, MD 20892, USA.
N1  - Accession Number: 20002013316.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2902±1082 (standard error of the mean) or 109 genomes/105 cells, respectively. Eleven of 14 (79%) to 13 of 15 (87%) of the ganglia were PCR positive for VZV gene 29, 31, or 62. Pooling of the results for the three VZV genes yielded a mean of 258±38 genomes/105 ganglion cells. These levels of latent viral genome loads have implications for virus distribution in and reactivation from human sensory ganglia.
KW  - fluorescence
KW  - ganglia
KW  - genes
KW  - genomes
KW  - glycoproteins
KW  - human diseases
KW  - polymerase chain reaction
KW  - quantitative techniques
KW  - Human herpesvirus 1
KW  - Human herpesvirus 2
KW  - Human herpesvirus 3
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Varicellovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - herpes simplex virus 1
KW  - herpes simplex virus 2
KW  - PCR
KW  - varicella-zoster virus
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characteristics of pesticide use in a pesticide applicator cohort: the agricultural health study.
AU  - Alavanja, M. C. R.
AU  - Sandler, D. P.
AU  - McDonnell, C. J.
AU  - Lynch, C. F.
AU  - Pennybacker, M.
AU  - Zahm, S. H.
AU  - Mage, D. T.
AU  - Steen, W. C.
AU  - Wintersteen, W.
AU  - Blair, A.
JO  - Environmental Research, Section A
JF  - Environmental Research, Section A
Y1  - 1999///
VL  - 80
IS  - 2
SP  - 172
EP  - 179
AD  - Alavanja, M. C. R.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland Z0892, USA.
N1  - Accession Number: 19990502463.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref.
N2  - Data were collected during 1994-95 on recent and historic pesticide use, pesticide application methods, and farm characteristics from 35 879 restricted-use pesticide applicators. This represented the first 2 years of the Agricultural Health Study, which is studying a large cohort of private and commercial licensed pesticide applicators in Iowa (which are certified) and North Carolina (which are licensed). In Iowa, commercial applicators apply pesticides more frequently per year than private applicators in either state. Iowa private and Iowa commercial applicators tended to use the same type of pesticides (r² = 0.88). White and non-white private applicators tended to use the same type of pesticides (r² = 0.89) as did male and female private applicators (Iowa r² = 0.85 and North Carolina r² = 0.84). There was less similarity between the types of pesticides used in Iowa and North Carolina private applicators. A greater proportion of Iowa private applicators used personal protective equipment than in North Carolina, and pesticide application methods varied by state.
KW  - application methods
KW  - applicators
KW  - insecticides
KW  - pest control
KW  - pesticides
KW  - protective clothing
KW  - usage
KW  - Iowa
KW  - North Carolina
KW  - USA
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - South Atlantic States of USA
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characteristics of persons who self-reported a high pesticide exposure event in the agricultural health study.
AU  - Alavanja, M. C. R.
AU  - Sandler, D. P.
AU  - McDonnell, C. J.
AU  - Mage, D. T.
AU  - Kross, B. C.
AU  - Rowland, A. S.
AU  - Blair, A.
JO  - Environmental Research, Section A
JF  - Environmental Research, Section A
Y1  - 1999///
VL  - 80
IS  - 2
SP  - 180
EP  - 186
AD  - Alavanja, M. C. R.: Epidemiology and Biostatistics Program, National Cancer Institute, 6130 Executive Boulevard, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19991103614.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Agricultural Entomology; Weeds
N2  - Data on pesticide application practices and health were obtained from a cohort of licensed pesticide applicators from Iowa and North Carolina, USA, 14% of whom reported having high pesticide exposure events (HPEEs). Females, applicators from North Carolina and private applicators were at lower risk from an HPEE. Pesticide applicators with an HPEE were more likely to delay changing their work clothing after pesticide application, mix their work clothing with the family wash, delay washing until the end of the work day, wash within the house after applications, store pesticides in their home and apply pesticides near the house and drinking wells. Personal repair of application equipment was significantly more frequent among HPEE cases, as was their first application having taken place more than 10 years previously. Over a working lifetime, at least 1 HPEE was reported by 22% of all commercial applicators in Iowa, 15% of Iowa private applicators and 10% of private applicators in North Carolina.
KW  - agricultural entomology
KW  - application
KW  - exposure
KW  - health
KW  - health hazards
KW  - herbicides
KW  - nontarget effects
KW  - occupational hazards
KW  - pesticides
KW  - safety at work
KW  - Iowa
KW  - North Carolina
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - South Atlantic States of USA
KW  - occupational safety
KW  - United States of America
KW  - weedicides
KW  - weedkillers
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Occupational Health and Safety (VV900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HPV 16 antibody prevalence in Jamaica and the United States reflects differences in cervical cancer rates.
AU  - Strickler, H. D.
AU  - Kirk, G. D.
AU  - Figueroa, J. P.
AU  - Ward, E.
AU  - Braithwaite, A. R.
AU  - Escoffery, C.
AU  - Drummond, J.
AU  - Goebel, B.
AU  - Waters, D.
AU  - McClimens, R.
AU  - Manns, A.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1999///
VL  - 80
IS  - 3
SP  - 339
EP  - 344
SN  - 0020-7136
AD  - Strickler, H. D.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19992008340.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Public Health; Tropical Diseases
N2  - DNA of HPV 16 is found in about half of tumours tested, although population-based studies of human papillomavirus (HPV) DNA have often failed to find high rates of anogenital HPV infection in countries with high cervical cancer rates. To investigate this issue, serology was used to compare HPV 16 exposure in healthy volunteer blood donors in the USA (n=278, enrolled during 1996-97) and similar subjects from a country with 3-fold higher cervical cancer rates, Jamaica (n=257, enrolled during 1987-88). Jamaican sexually transmitted disease (STD) patients (n=831, 1994-95) were also studied to examine in detail the relation of HPV 16 antibodies with sexual history. Serology was conducted using an ELISA employing HPV 16 virus-like particles (VLPs). Age-adjusted seroprevalence rates were greatest among male (29%) and female (42%) STD patients, intermediate in male (19%) and female (24%) Jamaican blood donors and lowest among male (3%) and female (12%) US blood donors. The higher seroprevalence in women was significant, and prevalence tended to increase with age. In multivariate logistic regression, controlling for age and gender, Jamaican blood donors were 4.2-fold (95% CI 2.4-7.2) and STD patients 8.1-fold (95% CI 5.0-13.2) more likely to have HPV 16 VLP antibodies than US blood donors. Among STD patients, HPV 16 antibodies were associated with lifetime number of sex partners and years of sexual activity, as well as other factors. It is suggested that HPV 16 VLP antibodies are strongly associated with sexual behaviour. Moreover, exposure to HPV 16 appears to be much greater in Jamaica than in the USA, consistent with the high rate of cervical cancer in Jamaica.
KW  - age
KW  - antibodies
KW  - cervical cancer
KW  - disease prevalence
KW  - human diseases
KW  - neoplasms
KW  - risk factors
KW  - seroprevalence
KW  - sex
KW  - sexual behaviour
KW  - sexually transmitted diseases
KW  - Jamaica
KW  - USA
KW  - human papillomavirus 16
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Caribbean Community
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Threshold Countries
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - cancers
KW  - Human papillomavirus
KW  - Papovaviridae
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - STDs
KW  - United States of America
KW  - venereal diseases
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A study of adult T-cell leukemia/lymphoma incidence in central Brooklyn.
AU  - Levine, P. H.
AU  - Dosik, H.
AU  - Joseph, E. M.
AU  - Felton, S.
AU  - Bertoni, M. A.
AU  - Cervantes, J.
AU  - Moulana, V.
AU  - Miotti, A. B.
AU  - Goberdhan, L. J.
AU  - Lee, S. L.
AU  - Daouad, A.
AU  - DaCosta, M.
AU  - Jaffe, E. S.
AU  - Axiotis, C. A.
AU  - Cleghorn, F. R.
AU  - Kahn, A.
AU  - Welles, S. L.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1999///
VL  - 80
IS  - 5
SP  - 662
EP  - 666
SN  - 0020-7136
AD  - Levine, P. H.: National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992009047.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
N2  - A pilot 1-year surveillance programme was established to identify cases of adult T-cell leukaemia/lymphoma (ATL) in 7 of 10 hospitals serving the residents of 18 zip codes of central Brooklyn, New York, USA, with a combined population of 1 184 670. Of the 6198 in-patient beds in the catchment area, approx. 83% were covered. 12 incident cases of ATL were ascertained, all among persons of Afro-Caribbean descent, indicating an annual incidence in African-Americans in this community of approx. 3.2/100 000 person-years. Unexplained hypercalcaemia was the most useful screening method, identifying 3 of 5 patients not referred for possible ATL by a local haematologist. The female:male ratio was 3:1. The age pattern was different from that reported in the Caribbean Basin and closer to the pattern seen in Japan. It is concluded that this study supports evidence that human T-lymphotropic virus (HTLV-I) infection and ATL are endemic in central Brooklyn and it is suggested that a more intensive surveillance programme for this disease coupled with intervention efforts to reduce HTLV-I transmission are warranted.
KW  - adult T-cell leukaemia
KW  - disease prevalence
KW  - epidemiology
KW  - females
KW  - HTLV-I infections
KW  - human diseases
KW  - hypercalcaemia
KW  - males
KW  - surveillance
KW  - New York
KW  - USA
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - adult T-cell leukemia
KW  - HTLV-BLV group
KW  - hypercalcemia
KW  - hypercalcinemia
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the USA.
AU  - Groves, F. D.
AU  - Gridley, G.
AU  - Wacholder, S.
AU  - Shu, X. O.
AU  - Robison, L. L.
AU  - Neglia, J. P.
AU  - Linet, M. S.
JO  - British Journal of Cancer
JF  - British Journal of Cancer
Y1  - 1999///
VL  - 81
IS  - 1
SP  - 175
EP  - 178
SN  - 0007-0920
AD  - Groves, F. D.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-7244, USA.
N1  - Accession Number: 19992012028.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Public Health
N2  - Previous studies have suggested that infant vaccinations may reduce the risk of subsequent childhood leukaemia. Vaccination histories were compared in 439 children (ages 0-14) diagnosed with acute lymphoblastic leukaemia (ALL) in 9 Midwestern and Mid-Atlantic states (USA) between 1 January 1989 and 30 June 1993 and 439 controls selected by random-digit dialing and individually matched to cases on age, race and telephone exchange. Among matched pairs, similar proportions of cases and controls had received at least 1 dose of oral poliovirus (98%), diphtheria-tetanus-pertussis (97%), and measles-mumps-rubella (90%) vaccines. Only 47% of cases and 53% of controls had received any Haemophilus influenzae type b (Hib) vaccine (relative risk (RR)=0.73; 95% confidence interval (CI) 0.50-1.06). Although similar proportions of cases (12%) and controls (11%) received the polysaccharide Hib vaccine (RR=1.13; 95% CI 0.64-1.98), more controls (41%) than cases (35%) received the conjugate Hib vaccine (RR=0.57; 95% CI 0.36-0.89). Although no relationship was found between most infant vaccinations and subsequent risk of childhood ALL, the findings suggest that infants receiving the conjugate Hib vaccine may be at reduced risk of subsequent childhood acute lymphoblastic leukaemia. Further studies are needed to confirm this association and, if confirmed, to elucidate the underlying mechanism.
KW  - children
KW  - diphtheria
KW  - diphtheria pertussis tetanus vaccines
KW  - human diseases
KW  - immunization
KW  - infants
KW  - leukaemia
KW  - measles
KW  - measles mumps rubella vaccines
KW  - mumps
KW  - pertussis
KW  - risk
KW  - risk factors
KW  - rubella
KW  - tetanus
KW  - vaccination
KW  - vaccines
KW  - USA
KW  - Bordetella pertussis
KW  - Clostridium tetani
KW  - Corynebacterium diphtheriae
KW  - Haemophilus influenzae
KW  - Haemophilus influenzae type b
KW  - man
KW  - measles virus
KW  - mumps virus
KW  - rubella virus
KW  - Bordetella
KW  - Alcaligenaceae
KW  - Burkholderiales
KW  - Betaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Clostridium
KW  - Clostridiaceae
KW  - Clostridiales
KW  - Clostridia
KW  - Firmicutes
KW  - Corynebacterium
KW  - Corynebacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Haemophilus
KW  - Pasteurellaceae
KW  - Pasteurellales
KW  - Gammaproteobacteria
KW  - Haemophilus influenzae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Morbillivirus
KW  - Paramyxovirinae
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Rubulavirus
KW  - Rubivirus
KW  - Togaviridae
KW  - positive-sense ssRNA viruses
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - acute lymphoblastic leukaemia
KW  - bacterium
KW  - blood cancer
KW  - German measles
KW  - immune sensitization
KW  - leucaemia
KW  - leukemia
KW  - lockjaw
KW  - United States of America
KW  - whooping cough
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Risk of stomach cancer in relation to consumption of cigarettes, alcohol, tea and coffee in Warsaw, Poland.
AU  - Chow WongHo
AU  - Swanson, C. A.
AU  - Lissowska, J.
AU  - Groves, F. D.
AU  - Sobin, L. H.
AU  - Nasierowska-Guttmejer, A.
AU  - Radziszewski, J.
AU  - Regula, J.
AU  - Hsing, A. W.
AU  - Shyla Jagannatha
AU  - Zatonski, W.
AU  - Blot, W. J.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1999///
VL  - 81
IS  - 6
SP  - 871
EP  - 876
SN  - 0020-7136
AD  - Chow WongHo: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 20001412245.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Human Nutrition
N2  - To identify reasons for the high incidence rates of stomach cancer in Poland, we conducted a population-based case-control study in Warsaw. Cases were residents aged 21 to 79 years who were newly diagnosed with stomach cancer between March 1, 1994, and April 30, 1997. Controls were randomly selected from Warsaw residents registered at the nationwide Polish Electronic System of Residence Evidence, frequency-matched to cases by age and sex. Information on demographic characteristics; consumption of cigarettes, alcohol, tea and coffee; diet; medical history; family history of cancer; occupational history; and living conditions during adolescence was elicited by trained interviewers using a structured questionnaire. Included were 464 case (90% of eligible) and 480 controls (87% of eligible). Among men, the risk of stomach cancer was significantly elevated among current smokers (OR=1.7, 95% CI=1.1-2.7) but not among former smokers. The excess risk was largely confined to long-term and heavy smokers, with significant 2-fold excess risk among men who smoked 40 or more pack-years. Among women, an 80% increase in risk was observed in both current and former smokers but dose-response trends were less consistent than among men. Alcohol consumption was not clearly related to risk, and no association was found for drinking regular coffee or herbal tea or using milk/cream in coffee or tea. A significant reduction in risk was linked to daily tea drinking among women, but not among men. Our findings confirm an association with cigarette smoking, which is estimated to account for approximately 20% of stomach cancers diagnosed among Warsaw residents during the study period.
KW  - adolescents
KW  - alcohol intake
KW  - beverages
KW  - children
KW  - coffee
KW  - digestive tract
KW  - neoplasms
KW  - questionnaires
KW  - stomach
KW  - tea
KW  - tobacco smoking
KW  - Poland
KW  - Camellia sinensis
KW  - Coffea
KW  - man
KW  - Camellia
KW  - Theaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Rubiaceae
KW  - Rubiales
KW  - Gentianales
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - alcohol consumption
KW  - cancers
KW  - drinks
KW  - gastrointestinal tract
KW  - teenagers
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412245&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Intake of food groups and associated micronutrients in relation to risk of early-stage breast cancer.
AU  - Potischman, N.
AU  - Swanson, C. A.
AU  - Coates, R. J.
AU  - Gammon, M. D.
AU  - Brogan, D. R.
AU  - Curtin, J.
AU  - Brinton, L. A.
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1999///
VL  - 82
IS  - 3
SP  - 315
EP  - 321
SN  - 0020-7136
AD  - Potischman, N.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 20001412240.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 59-30-3, 68-26-8.  Subject Subsets: Human Nutrition
N2  - In a large case-control study of early-onset breast cancer, we evaluated risk related to a variety of food groups, associated micronutrients and non-nutritive constituents. Cases treated with chemotherapy appeared to have altered reporting of food intake and were excluded. Analyses were restricted to 568 cases with in situ and localized disease and 1451 population-based controls. Reduced risks were observed for high intake of cereals and grains [odds ratio (OR)=0.84, 95% confidence interval (CI)=0.6-1.1 for highest compared with lowest quartile], vegetables (OR=0.86, 95% CI=0.6-1.1), beans (OR=0.87, 95% CI=0.7-1.2) and fibre from beans (OR=0.88, 95% CI=0.7-1.2). However, no trends of decreasing risk across quartiles of increasing intake were observed. Risk was not associated with dietary constituents related to these food groups including dietary fibre, carotenoids, vitamins A, C and E and folate. Incorporation of information from vitamin supplements did not alter the results for micronutrients. Our data suggest that intakes of cereals and grains, vegetables and beans are associated with minimal, if any, reduction in risk of early-stage breast cancer among young women.
KW  - beans
KW  - carotenoids
KW  - cereals
KW  - diet studies
KW  - diets
KW  - drug therapy
KW  - fibre
KW  - folic acid
KW  - food intake
KW  - incorporation
KW  - intake
KW  - mammary gland neoplasms
KW  - mammary glands
KW  - neoplasms
KW  - nutrients
KW  - retinol
KW  - supplements
KW  - trace elements
KW  - vegetables
KW  - vitamin supplements
KW  - vitamins
KW  - women
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - axerophthol
KW  - cancers
KW  - chemotherapy
KW  - fiber
KW  - folacin
KW  - folate
KW  - mammary tumour
KW  - microelements
KW  - tetraterpenoids
KW  - United States of America
KW  - vegetable crops
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Fusarium mycotoxins in corn and corn products in a high-risk area for gastric cancer in Shandong Province, China.
AU  - Groves, F. D.
AU  - Zhang Lian
AU  - Chang YunSheng
AU  - Ross, P. F.
AU  - Casper, H.
AU  - Norred, W. P.
AU  - You WeiCheng
AU  - Fraumeni, J. F., Jr.
JO  - Journal of AOAC International
JF  - Journal of AOAC International
Y1  - 1999///
VL  - 82
IS  - 3
SP  - 657
EP  - 662
SN  - 1060-3271
AD  - Groves, F. D.: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892-7244, USA.
N1  - Accession Number: 19991201982.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Registry Number: 51481-10-8, 17924-92-4.  Subject Subsets: Animal Nutrition; Medical & Veterinary Mycology; Maize; Postharvest Research
N2  - To determine whether mycotoxins might account for the increased risk of stomach cancer among people consuming fermented pancakes in rural Linqu County in Shandong Province, China, specimens of corn [maize], cornmeal [maize meal], unfermented and fermented pancake batter, and cooked fermented pancakes were collected in 1996 from each of 16 households in Linqu County for analysis by the U.S. Department of Agriculture. Fumonisins B1, B2 and B3 were detected (≥0.5 µg/g) in 19, 25 and 6% of the maize specimens, respectively, as well as in various maize products. No type A trichothecenes were detected; however, the type B trichothecenes deoxynivalenol [vomitoxin] and 15-acetyldeoxynivalenol were detected (≥0.5 µg/g) in 58 and 17% of the maize specimens, respectively, and zearalenone was detected (≥0.5 µg/g) in 15% of the maize meal specimens. The mycotoxins were detected only at low levels (&lt;10 µg/g), which did not increase with fermentation. It is concluded that these findings do not support the hypothesis that mycotoxin contamination increases the risk of gastric cancer among those who consume fermented Chinese pancakes.
KW  - acetyldeoxynivalenols
KW  - cereal products
KW  - contamination
KW  - foods
KW  - fumonisins
KW  - human diseases
KW  - maize
KW  - mycotoxins
KW  - neoplasms
KW  - risk factors
KW  - rural areas
KW  - stomach
KW  - vomitoxin
KW  - zearalenone
KW  - China
KW  - Fusarium
KW  - man
KW  - Zea mays
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Zea
KW  - Poaceae
KW  - Cyperales
KW  - monocotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancers
KW  - corn
KW  - deoxynivalenol
KW  - f-2 toxin
KW  - fungal toxins
KW  - fungus
KW  - Hyphomycetes
KW  - People's Republic of China
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Storage Problems and Pests of Food (QQ111) 
KW  - Food Contamination, Residues and Toxicology (QQ200) 
KW  - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW  - Feed Contamination, Residues and Toxicology (RR200) 
KW  - Crop Produce (QQ050) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evolution of precancerous lesions in a rural chinese population at high risk of gastric cancer.
AU  - You WeiCheng
AU  - Li JiYou
AU  - Blot, W. J.
AU  - Chang YunSheng
AU  - Jin MaoLin
AU  - Gail, M. H.
AU  - Zhang Lian
AU  - Liu WeiDong
AU  - Ma JunLing
AU  - Hu YuanRen
AU  - Mark, S. D.
AU  - Correa, P.
AU  - Fraumeni, J. F., Jr.
AU  - Xu GuangWei
JO  - International Journal of Cancer
JF  - International Journal of Cancer
Y1  - 1999///
VL  - 83
IS  - 5
SP  - 615
EP  - 619
SN  - 0020-7136
AD  - You WeiCheng: National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 20002010706.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Subject Subsets: Tropical Diseases
N2  - The objective was to determine the rates of transition from early to advanced gastric lesions in a population in Linqu County, China, where the gastric cancer (GC) rates are among the highest in the world. An endoscopic screening survey was launched during 1989-90 among 3399 residents aged 34-64 years with precancerous lesions diagnosed from biopsies taken from 7 standard locations in the stomach and from any suspicious sites. The cohort was subsequently followed, with endoscopic and histopathological examinations conducted in 1994. Logistic regression analysis was used to estimate odds ratios (ORs) of progression to advanced lesions of various levels of severity as a function of age, sex and baseline pathology. The rates of progression were higher among older subjects, among men and among subjects with more extensive gastric lesions. 34 incident GCs were identified during the follow-up period. The ORs of GC, adjusted for age and sex, varied from 17.1, for those with baseline diagnoses of superficial intestinal metaplasia (IM), to 29.3, for those with deep IM or mild dysplasia (DYS) or IM with glandular atrophy and neck hyperplasia, to 104.2, for those with moderate or severe DYS, as compared with subjects with superficial gastritis (SG) or chronic atrophic gastritis (CAG) at baseline. It is concluded that the prospective study of a high-risk population revealed sharp increases in the risk of GC and advanced precursor lesions according to the severity of lesions diagnosed at the start of follow-up.
KW  - atrophic gastritis
KW  - disease course
KW  - dysplasia
KW  - gastritis
KW  - human diseases
KW  - hyperplasia
KW  - lesions
KW  - neoplasms
KW  - pathogenesis
KW  - pathology
KW  - rural areas
KW  - stomach cancer
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancers
KW  - disease progression
KW  - gastric atrophy
KW  - People's Republic of China
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002010706&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectoris.
AU  - Blum, A.
AU  - Porat, R.
AU  - Rosenschein, U.
AU  - Keren, G.
AU  - Roth, A.
AU  - Laniado, S.
AU  - Miller, H.
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
Y1  - 1999///
VL  - 83
IS  - 10
SP  - 1488
EP  - 1490
SN  - 0002-9149
AD  - Blum, A.: Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19991410322.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 74-79-3, 10102-43-9.  Subject Subsets: Human Nutrition
N2  - 10 men with intractable angina pectoris unresponsive to maximum medical therapy and in an end stage condition with no further possible intervention were administered L-arginine for 3 months. There was a significant improvement in clinical condition and and a decrease in cell adhesion molecule and cytokine levels. It is concluded that L-arginine may be therapeutic.
KW  - amino acids
KW  - arginine
KW  - diet
KW  - heart diseases
KW  - nitric oxide
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - angina pectoris
KW  - chest pains
KW  - coronary diseases
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410322&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Norepinephrine spillover in forearm and subcutaneous adipose tissue before and after eating.
AU  - Patel, J. N.
AU  - Eisenhofer, G.
AU  - Coppack, S. W.
AU  - Miles, J. M.
JO  - Journal of Clinical Endocrinology and Metabolism
JF  - Journal of Clinical Endocrinology and Metabolism
Y1  - 1999///
VL  - 84
IS  - 8
SP  - 2815
EP  - 2819
SN  - 0021-972X
AD  - Patel, J. N.: National Institute of Neurological Disorders and Stroke, National institutes of Health, 10 Centre Drive, MSC-1424, Building 10, Room 6N252, Bethesda, Maryland 20892-1424, USA.
N1  - Accession Number: 19991415402.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 51-43-4, 9004-10-8, 51-40-1, 51-41-2, 69815-49-2.  Subject Subsets: Human Nutrition
N2  - The effect of feeding on systemic and local sympathetic nervous system activity and lipolysis was studied in lean healthy subjects (3 women and 5 men; aged 27.0±2.0 years; body mass index, 23.4±1.2) using isotope dilution methodology and arterio-venous sampling. Feeding increased arterial norepinephrine (NE) concentration (mean premeal, 0.96±0.12 nmol/litre; mean postmeal, 1.28±0.14 nmol/litre; P&lt;0.02) and total body NE spillover (mean premeal, 2.11±0.30 nmol/min per litre; mean postmeal, 2.76±0.31 nmol/min per litre; P&lt;0.02), whereas the arterial epinephrine concentration decreased (mean premeal, 289±61 pmol/litre; mean postmeal, 170±5 pmol/litre; P&lt;0.02). Palmitate concentration and total body systemic rate of appearance of palmitate declined postprandially (mean premeal, 117±15 µmol/min; mean postmeal, 38±4 µmol/min; P&lt;0.01). NE spillover increased by the same proportion in both forearm and adipose tissue. It is concluded that a meal caused differential changes in systemic sympatho-adrenal activity and an increase in sympathetic activity in adipose tissue postprandially. However, this increase in postprandial sympathetic activity was not enough to overcome the inhibition of lipolysis by insulin.
KW  - adipose tissue
KW  - anthropometric dimensions
KW  - epinephrine
KW  - feeding
KW  - food intake
KW  - insulin
KW  - lipolysis
KW  - nervous system
KW  - norepinephrine
KW  - sympathetic nervous system
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - adrenaline
KW  - anthropometric measurements
KW  - noradrenaline
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population: the North Carolina EPESE.
AU  - Corti, M. C.
AU  - Guralnik, J. M.
AU  - Ferrucci, L.
AU  - Izmirlian, G.
AU  - Leveille, S. G.
AU  - Pahor, M.
AU  - Cohen, H. J.
AU  - Pieper, C.
AU  - Havlik, R. J.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999///
VL  - 89
IS  - 3
SP  - 308
EP  - 314
SN  - 0090-0036
AD  - Corti, M. C.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, NIH, 7201 Wisconsin Ave, Room 3C-309, Bethesda, MD 20892-9205, USA.
N1  - Accession Number: 19992006416.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
N2  - This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina, USA were interviewed in 1986 and followed up for mortality until 1994. Hazard ratios (HRs) for all-cause and cause-specific mortality were calculated, with adjustment for sociodemographic and coronary heart disease (CHD) risk factors. Black persons had higher mortality rates than Whites at young-old age (65-80 years) but had significantly lower mortality rates after age 80. Black persons age 80 or older had a significantly lower risk of all-cause mortality (HR of Blacks vs Whites, 0.75; 95% confidence interval [CI]=0.62, 0.90) and of CHD mortality (HR 0.44; 95% CI=0.30, 0.66). These differences were not observed for other causes of death. Racial differences in mortality are modified by age. This mortality crossover could be attributed to selective survival of the healthiest oldest Blacks or to other biomedical factors affecting longevity after age 80. Because the crossover was observed for CHD deaths only, age overreporting by Black older persons seems an unlikely explanation of the mortality differences.
KW  - blacks
KW  - cardiovascular diseases
KW  - ethnic groups
KW  - heart diseases
KW  - human diseases
KW  - mortality
KW  - races
KW  - whites
KW  - North Carolina
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Appalachian States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - South Atlantic States of USA
KW  - coronary diseases
KW  - death rate
KW  - racial differences
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006416&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Residential radon exposure and risk of lung cancer in Missouri.
AU  - Alavanja, M. C. R.
AU  - Lubin, J. H.
AU  - Mahaffey, J. A.
AU  - Brownson, R. C.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999///
VL  - 89
IS  - 7
SP  - 1042
EP  - 1048
SN  - 0090-0036
AD  - Alavanja, M. C. R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 8000, Mail Stop 8000, Bethesda, MD 20892, USA.
N1  - Accession Number: 20002005795.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 10043-92-2. 
N2  - This study investigated residential radon exposure and lung cancer risk, using both standard radon dosimetry and a new radon monitoring technology that, evidence suggests, is a better measure of cumulative radon exposure. Missouri women (aged 30 to 84 years) newly diagnosed with primary lung cancer during 1 January 1993-31 January 1994 were invited to participate in this population-based case-control study. Both indoor air radon detectors and CR-39 alpha-particle detectors (surface monitors) were used. When surface monitors were used, a significant trend in lung cancer odds ratios was observed for 20-year time-weighted-average radon concentrations. When surface monitors were used, but not when standard radon dosimetry was used, a significant lung cancer risk was found for radon concentrations at and above the action level for mitigation of houses currently used in the USA (148 Bqm-3). The risk was below the action level used in Canada (750 Bqm-3) and many European countries (200-400 Bqm-3).
KW  - dwellings
KW  - human diseases
KW  - lung cancer
KW  - neoplasms
KW  - radon
KW  - risk factors
KW  - women
KW  - Missouri
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancers
KW  - United States of America
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Pollution and Degradation (PP600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Adolescent reproductive events and subsequent breast cancer risk.
AU  - Marcus, P. M.
AU  - Baird, D. D.
AU  - Millikan, R. C.
AU  - Moorman, P. G.
AU  - Qaqish, B.
AU  - Newman, B.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999///
VL  - 89
IS  - 8
SP  - 1244
EP  - 1247
SN  - 0090-0036
AD  - Marcus, P. M.: Biometry Branch Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19990404668.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - This study investigated the relationship between reproductive events during adolescence and subsequent breast cancer risk. Logistic regression models used self-reported data from 862 case patients and 790 controls in the Carolina Breast Cancer Study. Miscarriage, induced abortion, and full-term pregnancy before 20 years of age were not associated with breast cancer. Among pre-menopausal women, breast-feeding before 20 years of age was inversely associated with disease. Oral contraceptive use before 18 years of age was positively associated with disease risk among African American women only. Pregnancy during adolescence does not appear to influence breast cancer risk, but breast-feeding may. A possible increased breast cancer risk among African American women who used oral contraceptives as adolescents warrants further study.
KW  - adolescents
KW  - breast feeding
KW  - children
KW  - ethnic groups
KW  - induced abortion
KW  - infants
KW  - mammary gland neoplasms
KW  - models
KW  - oral contraceptives
KW  - pregnancy
KW  - risk factors
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - gestation
KW  - mammary tumour
KW  - teenagers
KW  - United States of America
KW  - Milk and Dairy Produce (QQ010) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990404668&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers.
AU  - Stolzenberg-Solomon, R. Z.
AU  - Albanes, D.
AU  - Nieto, F. J.
AU  - Hartman, T. J.
AU  - Tangrea, J. A.
AU  - Rautalahti, M.
AU  - Sehlub, J.
AU  - Virtamo, J.
AU  - Taylor, P. R.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1999///
VL  - 91
IS  - 6
SP  - 535
EP  - 541
SN  - 0027-8874
AD  - Stolzenberg-Solomon, R. Z.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19991404935.  Publication Type: Journal Article.  Language: English.  Number of References: 59 ref. Registry Number: 59-30-3, 65-23-6.  Subject Subsets: Human Nutrition
N2  - A nested case-control study within the α-Tocopherol, β-Carotene Cancer Prevention Study cohort of 29 133 male Finnish smokers aged 50-69 years was conducted. 126 subjects with incident exocrine pancreatic cancer were matched by date of baseline blood draw (±30 days), study centre, age (±5 years), trial intervention group, and completion of dietary history to 247 control subjects, who were alive and free from cancer at the time the case subjects were diagnosed. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined by use of conditional logistic regression. Reported P values are two-tailed. Serum folate and pyridoxal-5′-phosphate (PLP) concentrations showed significant inverse dose-response relationships with pancreatic cancer risk, with the highest serum tertiles having approximately half the risk of the lowest (folate: OR=0.45; 95% CI=0.24-0.82; P for trend=0.009, and PLP: OR=0.48; 95% CI=0.26-0.88; P for trend=0.02). An increased pancreatic cancer risk was also observed with greater exposure to cigarettes (pack-years (number of packs smoked per day×number of years of smoking), highest versus lowest quartile: OR=2.13; 95% CI=1.13-3.99; P for trend=0.04). It is concluded that maintaining adequate folate and pyridoxine status may reduce the risk of pancreatic cancer and confirm the risk previously associated with cigarette smoking.
KW  - blood chemistry
KW  - diet
KW  - dietary history
KW  - folic acid
KW  - neoplasms
KW  - pancreas
KW  - pyridoxine
KW  - tobacco smoking
KW  - Finland
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - OECD Countries
KW  - Scandinavia
KW  - Northern Europe
KW  - Europe
KW  - cancers
KW  - folacin
KW  - folate
KW  - food history
KW  - Human Physiology and Biochemistry (VV050) 
KW  - Human Nutrition (General) (VV100) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404935&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions.
AU  - Liaw KaiLi
AU  - Glass, A. G.
AU  - Manos, M. M.
AU  - Greer, C. E.
AU  - Scott, D. R.
AU  - Sherman, M.
AU  - Burk, R. D.
AU  - Kurman, R. J.
AU  - Wacholder, S.
AU  - Rush, B. B.
AU  - Cadell, D. M.
AU  - Lawler, P.
AU  - Tabor, D.
AU  - Schiffman, M.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1999///
VL  - 91
IS  - 11
SP  - 954
EP  - 960
SN  - 0027-8874
AD  - Liaw KaiLi: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
N1  - Accession Number: 19992009700.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Subject Subsets: Public Health
N2  - To clarify the role of human papillomavirus (HPV) in the aetiology of squamous intra-epithelial lesions (SIL), the risk of SIL was investigated prospectively following polymerase chain reaction (PCR)-based DNA testing for a wide range of genital HPV types in a cohort of initially cytologically normal women. Starting in April 1989, 17 654 women who were receiving routine cytological screening at Kaiser Permanente (Portland, OR, USA) were followed for the development of SIL. During follow-up, 380 incident case patients and 1037 matched control subjects were eligible for this nested case-control study. Cervical lavages collected at enrollment and, later, at the time of case diagnosis (or the corresponding time for selection of control subjects) were tested for HPV DNA using a PCR-based method. The data were analysed as contingency tables with 2-sided P values or, for multivariable analyses, using odds ratios (ORs) with 95% confidence intervals (CIs). In comparison with initially HPV-negative women, women who tested positive for HPV DNA at enrollment were 3.8 times (95% CI=2.6-5.5) more likely to have low-grade SIL subsequently diagnosed for the first time during follow-up and 12.7 times more likely (95% CI=6.2-25.9) to develop high-grade SIL. At the time of diagnosis, the cross-sectional association of HPV DNA and SIL was extremely strong (OR=44.4 and 95% CI=24.2-81.5 for low-grade SIL and OR=67.1 and 95% CI=19.3-233.7 for high-grade SIL). HPV16 was the virus type most predictive of SIL, even low-grade SIL. These findings are consistent with the hypothesis that HPV infection is the primary cause of cervical neoplasia.
KW  - aetiology
KW  - carcinoma
KW  - cervical cancer
KW  - cervix
KW  - epithelium
KW  - human diseases
KW  - lesions
KW  - neoplasms
KW  - women
KW  - Oregon
KW  - USA
KW  - human papillomaviruses
KW  - man
KW  - Papillomavirus
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pacific Northwest States of USA
KW  - Pacific States of USA
KW  - Western States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Papillomaviridae
KW  - cancers
KW  - causal agents
KW  - etiology
KW  - human papillomavirus
KW  - Papovaviridae
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009700&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Changing geographic patterns of lung cancer mortality in the United States, 1950 through 1994.
AU  - Devesa, S. S.
AU  - Grauman, D. J.
AU  - Blot, W. J.
AU  - Fraumeni, J. F., Jr.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1999///
VL  - 91
IS  - 12
SP  - 1040
EP  - 1050
SN  - 0027-8874
AD  - Devesa, S. S.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19992011316.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
N2  - Age-adjusted race- and sex-specific lung cancer mortality rates for 1950-94 were calculated for 9 Census Divisions and 508 State Economic Areas of the USA. Pronounced geographical variation in lung cancer rates was evident, with the patterns changing substantially over time. Among white males in the 1950s and 1960s, high rates were observed in urban areas of the northeast and north central states and in areas along the southeast and Gulf coasts. By the 1970s, the northern excess began to fade, with high rates starting to cover wider areas of the south. By the 1980s to the mid-1990s, clustering of elevated rates was prominent across the southeast and south central areas, with relatively low rates throughout much of the northeast. Among white females, little geographical variation was evident in the 1950s, but thereafter relatively high rates began to appear in clusters along the Atlantic and Pacific coasts. For both sexes, consistently low rates were seen in the mountain and the plains states. Rates among blacks were consistently elevated in northern areas and low across the south. It is concluded that the changing mortality patterns for lung cancer generally coincide with regional trends in cigarette smoking, indicating that public health measures aimed at smoking prevention and cessation should have a dramatic effect in reducing lung cancer rates.
KW  - epidemiology
KW  - ethnic groups
KW  - human diseases
KW  - lung cancer
KW  - lungs
KW  - mortality
KW  - neoplasms
KW  - surveillance
KW  - tobacco smoking
KW  - urban areas
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - death rate
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent trends in childhood cancer incidence and mortality in the United States.
AU  - Linet, M. S.
AU  - Ries, L. A. G.
AU  - Smith, M. A.
AU  - Tarone, R. E.
AU  - Devesa, S. S.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1999///
VL  - 91
IS  - 12
SP  - 1051
EP  - 1058
SN  - 0027-8874
AD  - Linet, M. S.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19992011317.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
N2  - Cancers diagnosed in 14 540 children aged &lt;15 years during 1975-95 and reported to 9 population-based registries in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program were investigated. Age-adjusted incidence was analysed according to anatomical site and histological categories of the International Classification of Childhood Cancer. Age-adjusted US mortality rates were calculated. Trends in rates were evaluated by use of standard regression methods. A modest rise in the incidence of leukaemia, the most common childhood cancer, was largely due to an abrupt increase from 1983 to 1984; rates have decreased slightly since 1989. For brain and other central nervous system (CNS) cancers, incidence rose modestly, although statistically significantly (two-sided P=0.020), largely from 1983 to 1986. A few rare childhood cancers demonstrated upward trends (the 40% of skin cancers designated as dermatofibrosarcomas, adrenal neuroblastomas and retinoblastomas, the latter 2 in infants only). In contrast, incidence decreased modestly but statistically significantly for Hodgkin's disease (two-sided P=0.037). Mortality rates declined steadily for all major childhood cancer categories, although less rapidly for brain/CNS cancers. It is concluded that there was no substantial change in incidence for the major paediatric cancers, and rates remained relatively stable since the mid-1980s. The modest increases that were observed for brain/CNS cancers, leukaemia, and infant neuroblastoma were confined to the mid-1980s. The patterns indicated that the increases likely reflected diagnostic improvements or reporting changes. Dramatic declines in childhood cancer mortality represent treatment-related improvements in survival.
KW  - central nervous system
KW  - children
KW  - disease prevalence
KW  - epidemiology
KW  - Hodgkin's disease
KW  - human diseases
KW  - incidence
KW  - infants
KW  - leukaemia
KW  - mortality
KW  - neoplasms
KW  - skin
KW  - skin cancer
KW  - surveillance
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - blood cancer
KW  - cancer of the lymph nodes
KW  - cancers
KW  - CNS
KW  - death rate
KW  - dermis
KW  - leucaemia
KW  - leukemia
KW  - lymphogranuloma
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011317&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Brain and other central nervous system cancers: recent trends in incidence and mortality.
AU  - Legler, J. M.
AU  - Ries, L. A. G.
AU  - Smith, M. A.
AU  - Warren, J. L.
AU  - Heineman, E. F.
AU  - Kaplan, R. S.
AU  - Linet, M. S.
JO  - Journal of the National Cancer Institute
JF  - Journal of the National Cancer Institute
Y1  - 1999///
VL  - 91
IS  - 16
SP  - 1382
EP  - 1390
SN  - 0027-8874
AD  - Legler, J. M.: Cancer Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19992012086.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref. Subject Subsets: Public Health
N2  - During the 1980s, the incidence of primary malignant brain and other central nervous system tumours (brain cancer) was reported to be increasing among all age groups in the USA, while mortality was declining for persons &lt;65 years of age. Data was analysed to provide updates on incidence and mortality trends for brain cancer in the USA and to examine these patterns to determine their causes. Data on incidence of brain cancer, overall and according to histology and anatomic site, and on relative survival were obtained from the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute for 1975-95. Mortality data were obtained from the National Center for Health Statistics. Medicare procedure claims from the National Cancer Institute's SEER-Medicare database were used for imaging trends. Statistically significant changes in incidence trends were identified, and annual percent changes were computed for log linear models. Rates stabilized for all age groups during the most recent period for which SEER data were available, except for the group containing individuals ≥85 years of age. Mortality trends continued to decline for the younger age groups, and the steep increases in mortality seen in the past for the elderly slowed substantially. Patterns differed by age group according to the site and grade of tumours between younger and older patients. During the last decade, use of computed tomography scans was relatively stable for those 65-74 years of age, but increased among those ≥85 years of age. It is suggested that improvements in diagnosis and changes in the diagnosis and treatment of elderly patients provide likely explanations for the observed patterns in brain cancer trends.
KW  - age
KW  - age groups
KW  - brain
KW  - brain diseases
KW  - central nervous system
KW  - computed tomography
KW  - disease prevalence
KW  - elderly
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - mortality
KW  - neoplasms
KW  - nervous system diseases
KW  - statistics
KW  - survival
KW  - trends
KW  - tumours
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - aged
KW  - brain disorders
KW  - cancers
KW  - cerebrum
KW  - CNS
KW  - death rate
KW  - elderly people
KW  - neuropathy
KW  - older adults
KW  - senior citizens
KW  - tumors
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012086&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium falciparum: invasion of Aotus monkey red blood cells and adaptation to Aotus monkeys.
AU  - Kaneko, O.
AU  - Soubes, S. C.
AU  - Miller, L. H.
JO  - Experimental Parasitology
JF  - Experimental Parasitology
Y1  - 1999///
VL  - 93
IS  - 2
SP  - 116
EP  - 119
SN  - 0014-4894
AD  - Kaneko, O.: Malaria Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room B1-37, 4 Center Drive, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000803661.  Publication Type: Journal Article.  Language: English.  Number of References: 16 ref. Subject Subsets: Protozoology
N2  - The in vitro infection of Aotus and human erythrocytes by multiple clones and lines of Plasmodium falciparum revealed 3 patterns of cell invasion. Group 1 clones/lines invaded Aotus cells at a rate usually &gt;40% of the rate of invasion of human control cells. Three of these (Malayan Camp, Camp/A1 and FVO) were previously adapted to Aotus and the other group 1 parasites are thought to be Aotus-adapted FVO that had contaminated and overgrown other lines. Group 2 parasites contained clones with an invasion rate 3.5-19.2% that of human control cells and had never been in Aotus before. Group 3 consisted of a single clone (3D7) that was resistant to invasion of Aotus cells (invasion rate 0-1.2% that of human control cells).
KW  - adaptation
KW  - cell invasion
KW  - cell lines
KW  - clones
KW  - erythrocytes
KW  - experimental infection
KW  - host parasite relationships
KW  - in vitro
KW  - infectivity
KW  - laboratory animals
KW  - parasites
KW  - strain differences
KW  - strains
KW  - Aotus
KW  - Plasmodium falciparum
KW  - Primates
KW  - protozoa
KW  - Cebidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - blood red cells
KW  - experimental transmission
KW  - parasite host relationships
KW  - red blood cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000803661&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals.
AU  - Rabkin, C. S.
AU  - Yang QuanEn
AU  - Goedert, J. J.
AU  - Nguyen, G.
AU  - Mitsuya, H.
AU  - Sei, S.
JO  - Blood
JF  - Blood
Y1  - 1999///
VL  - 93
IS  - 6
SP  - 1838
EP  - 1842
SN  - 0006-4971
AD  - Rabkin, C. S.: Viral Epidemiology Branch, HIV and AIDS Malignancy Branch, and Experimental Retrovirology Section, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19992007144.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Subject Subsets: Public Health
N2  - A group of 746 HIV-1-infected persons from the USA was examined for associations of stromal cell-derived factor 1 (SDF-1) chemokine and CCR5 and CCR2 chemokine receptor gene variants with the risk of B-cell non-Hodgkin's lymphoma (NHL). The SDF1-3′A chemokine variant, which is carried by 37% of whites and 11% of blacks, was associated with approximate doubling of the NHL risk in heterozygotes and roughly a 4-fold increase in homozygotes. After a median follow-up of 11.7 years, NHL developed in 6 (19%) of 30 SDF1-3′A/3′A homozygotes and 22 (10%) of 202 SDF1-+/3′A heterozygotes, compared with 24 (5%) of 514 wild-type subjects. The acquired immunodeficiency syndrome (AIDS)-protective chemokine receptor variant CCR5-Δ32 was highly protective against NHL, whereas the AIDS-protective variant CCR2-64l had no significant effect. Racial differences in SDF1-3′A frequency may contribute to the lower risk of HIV-1-associated NHL in blacks compared with whites. SDF-1 genotyping of HIV-1-infected patients may identify subgroups warranting enhanced monitoring and targeted interventions to reduce the risk of NHL.
KW  - chemokines
KW  - genetics
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - lymphoma
KW  - mutations
KW  - receptors
KW  - risk
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007144&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Detection of human herpesvirus-8 and Epstein-Barr virus DNA in primary intraocular lymphomas.
AU  - Chan ChiChao
AU  - Shen DeFen
AU  - Whitcup, S. M.
AU  - Nussenblatt, R. B.
AU  - Phuc LeHoang
AU  - Roberge, F. G.
AU  - Cassoux, N.
AU  - Herbort, C.
AU  - Zhuang, Z. P.
T2  - Blood
JO  - Blood
JF  - Blood
Y1  - 1999///
VL  - 93
IS  - 8
SP  - 2749
EP  - 2751
SN  - 0006-4971
AD  - Chan ChiChao: National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992010248.  Publication Type: Correspondence.  Language: English.  Number of References: 10 ref. Registry Number: 9007-49-2. 
KW  - DNA
KW  - eyes
KW  - human diseases
KW  - human herpesviruses
KW  - lymphoma
KW  - pathogenesis
KW  - USA
KW  - Human herpesvirus 4
KW  - human herpesvirus 8
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - Rhadinovirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - deoxyribonucleic acid
KW  - Epstein-Barr virus
KW  - human herpesvirus
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010248&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4+ T cells and decreases their susceptibility to apoptosis in vitro and in vivo.
AU  - Sloand, E. M.
AU  - Kumar, P. N.
AU  - Kim, S.
AU  - Aniruddho Chaudhuri
AU  - Weichold, F. F.
AU  - Young, N. S.
JO  - Blood
JF  - Blood
Y1  - 1999///
VL  - 94
IS  - 3
SP  - 1021
EP  - 1027
SN  - 0006-4971
AD  - Sloand, E. M.: National Institutes of Health, National Heart, Lung and Blood Institute, 31 Center Dr. MSC 2490, Building 31, Room 4A11, Bethesda, MD, 20892-2490, USA.
N1  - Accession Number: 20002006881.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Registry Number: 155213-67-5. 
N2  - The effect of protease inhibitors on Fas-Receptor (CD95)(Fas-R (CD95)), interleukin converting enzyme (ICE (caspase 1)) expression, apoptosis, and cell death in CD4+ T cells of (1) human immunodeficiency virus (HIV)-infected patients who were receiving protease inhibitors, and (2) normal and patient CD4+ T cells cultured with a protease inhibitor in vitro was investigated. 15 American patients with advanced HIV disease on treatment showed dramatically decreased CD4+ T-cell ICE expression, diminished apoptosis, and increased numbers of CD4+ cells within 6 weeks of institution of protease inhibitor therapy, and before down-modulation of Fas-R (CD95) expression was evident. To determine the role of HIV infection, the effect of ritonavir, a protease inhibitor, on normal and patient cells in vitro was investigated. Stimulated and unstimulated normal CD4+ T cells, cultured with protease inhibitor, demonstrated markedly decreased apoptosis and ICE expression (P=0.01). While Fas-R expression was not significantly altered during short-term culture by such treatment, Fas-Ligand (Fas-L) membrane expression of phytohaemagglutinin (PHA)-stimulated blood lymphocytes was decreased by protease inhibitor. In the presence of ritonavir, CD4+ T cells from HIV-infected patients showed similar changes in ICE intracellular levels without alteration of Fas expression. In conclusion, protease inhibitors appeared to decrease CD4+ T-cell ICE expression and apoptosis before they affected Fas-R expression in HIV-infected patients. This action was independent of HIV infection, as similar effects were seen in CD4+ T cells from normal controls. Some of the benefit of protease inhibitors may be related to modification of programmed cell death, which increases CD4+ T-cell number.
KW  - apoptosis
KW  - CD4 antigens
KW  - gene expression
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infections
KW  - interleukins
KW  - phytohaemagglutinins
KW  - proteinase inhibitors
KW  - ritonavir
KW  - T lymphocytes
KW  - Maryland
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - CD4
KW  - human immunodeficiency virus
KW  - phytohemagglutinins
KW  - protease inhibitors
KW  - T cells
KW  - United States of America
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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ER  - 

TY  - JOUR
T1  - HIV and HCV infection among drug users in Japan.
AU  - Wada, K.
AU  - Greberman, S. B.
AU  - Konuma, K.
AU  - Hirai, S.
JO  - Addiction
JF  - Addiction
Y1  - 1999///
VL  - 94
IS  - 7
SP  - 1063
EP  - 1069, 1093, 1099
SN  - 0965-2140
AD  - Wada, K.: National Center of Neurology and Psychiatry, National Institute of Mental Health, Division of Drug Dependence and Psychotropic Drug Clinical Research, 1-7-3 Kohnodai, Ichikawa-shi, Chiba 272-0827, Japan.
N1  - Accession Number: 19992011527.  Publication Type: Journal Article.  Language: English.  Language of Summary: French; Spanish.  Number of References: 16 ref.
N2  - The seroprevalence of human immunodeficiency virus (HIV), hepatitis C virus, injecting drug use, unsafe sexual behaviours, self-mutilation and tattoos was assessed in patients attending a drug and alcohol treatment centre in Japan. A cross-sectional survey was carried out at the National Sanitarium of Shimousa, Chiba, Japan, a 32-bed inpatient centre specializing in drug and alcohol treatment. HIV antibody, hepatitis C antibody, hepatitis B antigen and antibody levels were measured; questionnaires for history of sexual activities, needle and syringe use analysed; physical examination with assessment of self-amputated finger joints, tattoos, scars from lacerations and cigarette burns noted. No patients tested positive for anti-HIV. The seroprevalence of anti-HCV positives was 53.8% of methamphetamine-dependent patients, 18.4% of solvent-dependent patients and 5.6% of alcohol-dependent patients. Past needle sharing was reported by 82.1% of methamphetamine-dependent patients, 18.4% of solvent-dependent patients and 5.6% of alcohol-dependent patients. A history of syringe sharing was reported by 87.2% of methamphetamine-dependent patients. More than two-thirds of all patients reported contact with commercial sex workers. Casual sexual contacts were more common among solvent and methamphetamine-dependent patients than those dependent on alcohol. Tattoos and cigarette burns were more common among methamphetamine and solvent-dependent patients than among alcohol-dependent patients. Among the methamphetamine-dependent patients, 20.5% reported self-amputated finger joints compared with none in the other patient groups. HCV prevalence is a significant problem among methamphetamine users in Japan, probably because of a high rate of needle and/or syringe sharing. Although HIV infection is currently negligible, the very high rate of needle and syringe sharing could give rise to a significant increase in the HIV rate among drug users in the future.
KW  - amphetamines
KW  - contamination
KW  - disease prevalence
KW  - disease transmission
KW  - drug users
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - infection
KW  - injecting drug users
KW  - injection
KW  - sexual behaviour
KW  - surveys
KW  - trauma
KW  - viral diseases
KW  - Japan
KW  - hepatitis C virus
KW  - man
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - drug abusers
KW  - human immunodeficiency virus
KW  - i.v. drug abusers
KW  - i.v. drug users
KW  - intravenous drug users
KW  - methamphetamines
KW  - self mutilation
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - traumas
KW  - viral infections
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients.
AU  - Kaufman, S.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1999///
VL  - 96
IS  - 6
SP  - 3160
EP  - 3164
SN  - 0027-8424
AD  - Kaufman, S.: Laboratory of Neurochemistry, National Institute of Mental Health, 36 Convent Drive, MSC 4096, Building 36, Room 3D30, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991407014.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 63-91-2.  Subject Subsets: Human Nutrition
N2  - The derivation of a quantitative model of phenylalanine metabolism in humans is described. The model is based on the kinetic properties of pure recombinant human phenylalanine hydroxylase and on estimates of the in vivo rates of phenylalanine transamination and protein degradation. Calculated values for the steady-state concentration of blood phenylalanine, rate of clearance of phenylalanine from the blood after an oral load of the amino acid, and dietary tolerance of phenylalanine all agree well with data from normal as well as from phenylketonuric patients and obligate heterozygotes. These calculated values may help in the decision about the degree of restriction of phenylalanine intake that is necessary to achieve a satisfactory clinical outcome in classical patients and in those with milder forms of the disease.
KW  - amino acids
KW  - analytical methods
KW  - blood
KW  - diet
KW  - hyperphenylalaninaemia
KW  - intake
KW  - kinetics
KW  - metabolism
KW  - models
KW  - phenylalanine
KW  - phenylketonuria
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - hyperphenylalaninemia
KW  - Phenylalanine hydroxylase deficiency
KW  - Techniques and Methodology (ZZ900) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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ER  - 

TY  - JOUR
T1  - Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography.
AU  - Tataranni, P. A.
AU  - Gautier, J. F.
AU  - Chen KeWei
AU  - Uecker, A.
AU  - Bandy, D.
AU  - Salbe, A. D.
AU  - Pratley, R. E.
AU  - Lawson, M.
AU  - Reiman, E. M.
AU  - Ravussin, E.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1999///
VL  - 96
IS  - 8
SP  - 4569
EP  - 4574
SN  - 0027-8424
AD  - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases-National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA.
N1  - Accession Number: 19991407756.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 9004-10-8.  Subject Subsets: Human Nutrition
N2  - Regional cerebral blood flow (rCBF), a marker of neuronal activity, was measured in 11 healthy, normal-weight men by using positron emission tomography in a state of hunger (after 36-h fast) and a state of satiation (after a liquid meal). Hunger was associated with significantly increased rCBF in the vicinity of the hypothalamus and insular cortex and in additional paralimbic and limbic areas (orbitofrontal cortex, anterior cingulate cortex, and parahippocampal and hippocampal formation), thalamus, caudate, precuneus, putamen, and cerebellum. Satiation was associated with increased rCBF in the vicinity of the ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and inferior parietal lobule. Changes in plasma insulin concentrations in response to the meal were negatively correlated with changes in rCBF in the insular and orbitofrontal cortex. Changes in plasma free fatty acid concentrations in response to the meal were negatively correlated with changes in rCBF in the anterior cingulate and positively correlated with changes in rCBF in the dorsolateral prefrontal cortex. In conclusion, these findings raise the possibility that several regions of the brain participate in the regulation of hunger and satiation and that insulin and free fatty acids may be metabolic modulators of postprandial brain neuronal events. Although exploratory, the present study provides a foundation for investigating the human brain regions and cognitive operations that respond to nutritional stimuli.
KW  - appetite
KW  - blood flow
KW  - brain
KW  - cerebellum
KW  - fatty acids
KW  - hunger
KW  - hypothalamus
KW  - insulin
KW  - men
KW  - nervous system
KW  - satiety
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - brain cerebellum
KW  - cerebrum
KW  - Physiology of Human Nutrition (VV120) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms.
AU  - Walker, P. S.
AU  - Scharton-Kersten, T.
AU  - Krieg, A. M.
AU  - Love-Homan, L.
AU  - Rowton, E. D.
AU  - Udey, M. C.
AU  - Vogel, J. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1999///
VL  - 96
IS  - 12
SP  - 6970
EP  - 6975
SN  - 0027-8424
AD  - Walker, P. S.: Dermatology Branch, National Cancer Institute, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1908, USA.
N1  - Accession Number: 19990805942.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Registry Number: 9007-49-2, 9008-11-1.  Subject Subsets: Protozoology
N2  - Resistance to murine leishmaniasis correlates with development of a CD4+ T helper 1 (Th1)-predominant immune response. To determine whether immunostimulatory CpG-containing oligodeoxynucleotides (CpG-ODN), known to promote a Th1 immune response, could provide protection from Leishmania infection, CpG-ODN and freeze-thawed (F/T) L. major were coinjected intradermally into susceptible BALB/c mice. A Leishmania-specific Th1-predominant immune response was induced; 40% of animals were protected from subsequent challenge, with 0% protection of animals injected with F/T Leishmania organisms and PBS, F/T organisms and control ODN, or F/T organisms alone. More striking protection (65-95%) was seen in mice first infected with intact Leishmania and then injected with CpG-ODN, either at the site of infection or at a remote site. To determine whether the protection provided by CpG-ODN depended on interleukin (IL)-12 and interferon (IFN)-γ production, both IFN-γ-deficient mice and mice treated with neutralizing anti-IL-12 monoclonal antibody were first inoculated with Leishmania and then treated with either CpG-ODN, ODN or PBS. None of these IFN-γ-deficient mice survived (0, 0 and 0 of 20, respectively) and neutralization of IL-12 completely abolished the therapeutic protection provided by CpG-ODN (0 of 20 mice surviving). It was concluded that immunostimulatory DNA sequences probably exert systemic effects via IL-12 and IFN-γ-dependent mechanisms and hold considerable promise as both vaccine adjuvants and potential therapeutic agents.
KW  - CD4+ lymphocytes
KW  - disease resistance
KW  - DNA
KW  - experimental infections
KW  - immune response
KW  - immunostimulation
KW  - interferon
KW  - interleukin 12
KW  - laboratory animals
KW  - leishmaniasis
KW  - nucleotide sequences
KW  - parasites
KW  - T lymphocytes
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - CD4+ cells
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - immunity reactions
KW  - immunological reactions
KW  - leishmaniosis
KW  - oligodeoxynucleotides
KW  - resistance to disease
KW  - T cells
KW  - T4 lymphocytes
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression.
AU  - Davey, R. T., Jr.
AU  - Niranjan Bhat
AU  - Yoder, C.
AU  - Chun TaeWook
AU  - Metcalf, J. A.
AU  - Robin Dewar
AU  - Ven Natarajan
AU  - Lempicki, R. A.
AU  - Adelsberger, J. W.
AU  - Miller, K. D.
AU  - Kovacs, J. A.
AU  - Polis, M. A.
AU  - Walker, R. E.
AU  - Falloon, J.
AU  - Masur, H.
AU  - Gee, D.
AU  - Baseler, M.
AU  - Dimitrov, D. S.
AU  - Fauci, A. S.
AU  - Lane, H. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1999///
VL  - 96
IS  - 26
SP  - 15109
EP  - 15114
SN  - 0027-8424
AD  - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases, (NIAID), Bethesda, MD 20892, USA.
N1  - Accession Number: 20002009545.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref.
N2  - Identifying the immunological and virological consequences of discontinuing antiretroviral therapy in HIV-infected patients is of major importance in developing long-term treatment strategies for patients with HIV-1 infection. A trial was conducted to characterize these parameters after interruption of highly active antiretroviral therapy (HAART) in patients who had maintained prolonged viral suppression on antiretroviral drugs. 18 patients with CD4+ T cell counts ≥350 cells/µl and viral load below the limits of detection for ≥1 year while on HAART were enrolled prospectively in a trial [in the USA] in which HAART was discontinued. 12 of these patients had received prior IL-2 therapy and had low frequencies of resting, latently infected CD4 cells. Viral load relapse to &gt;50 copies/ml occurred in all 18 patients independent of prior IL-2 treatment, beginning most commonly during weeks 2-3 after cessation of HAART. The mean relapse rate constant was 0.45 (0.20 log10 copies) day-1, which was very similar to the mean viral clearance rate constant after drug resumption of 0.35 (0.15 log10 copies) day-1 (P=0.28). One patient experienced a relapse delay to week 7. All patients except one experienced a relapse burden to &gt;5000 RNA copies/ml. Ex vivo labelling with BrdUrd showed that CD4 and CD8 cell turnover increased after withdrawal of HAART and correlated with viral load whereas lymphocyte turnover decreased after reinitiation of drug treatment. It is concluded that virological relapse occurs rapidly in patients who discontinue suppressive drug therapy, even in patients with a markedly diminished pool of resting, latently infected CD4+ T cells.
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - drug therapy
KW  - highly active antiretroviral therapy
KW  - HIV-1 infections
KW  - human diseases
KW  - immunology
KW  - relapse
KW  - T lymphocytes
KW  - viral load
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - CD4+ cells
KW  - chemotherapy
KW  - HAART
KW  - human immunodeficiency virus type 1
KW  - recurrence of disease
KW  - relapses
KW  - T cells
KW  - T4 lymphocytes
KW  - United States of America
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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TY  - JOUR
T1  - Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis.
AU  - Charlab, R.
AU  - Valenzuela, J. G.
AU  - Rowton, E. D.
AU  - Ribeiro, J. M. C.
JO  - Proceedings of the National Academy of Sciences of the United States of America
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 1999///
VL  - 96
IS  - 26
SP  - 15155
EP  - 15160
SN  - 0027-8424
AD  - Charlab, R.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive, MSC 0425, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000505113.  Publication Type: Journal Article.  Language: English.  Number of References: 41 ref. Registry Number: 37288-34-9, 9033-33-4.  Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology
N2  - Subtractive cloning combined with biochemical approaches was used to discover activities in the salivary glands of L. longipalpis. Sequences of 9 full-length cDNA clones were obtained, 5 of which were possibly associated with blood-meal acquisition, each having cDNA similarity to: (i) Cimex lectularius apyrase, (ii) a 5′-nucleotidase/phosphodiesterase, (iii) a hyaluronidase, (iv) a protein containing a carbohydrate-recognition domain (CRD), and (v) a RGD-containing peptide with no significant matches to known proteins in the BLAST databases. Following these findings, the salivary apyrase activity of L. longipalpis was observed to be similar to that of Cimex apyrase in its metal requirements. The predicted isoelectric point of the putative apyrase matched the value found for Lutzomyia salivary apyrase. A 5′-nucleotidase, as well as hyaluronidase activity, was found in the salivary glands, and the CRD-containing cDNA matches the N-terminal sequence of the HPLC-purified salivary anticlotting protein. A cDNA similar to α-amylase was discovered and salivary enzymatic activity demonstrated for the first time in a bloodsucking arthropod. Full-length clones were also found coding for 3 proteins of unknown function matching, respectively, the N-terminal sequence of an abundant salivary protein, having similarity to the CAP superfamily of proteins and the Drosophila yellow protein. Finally, 2 partial sequences are reported that match possible housekeeping genes. The new nucleotide sequences were deposited in the EMBL/GenBank/DDBJ database under accession numbers AF131932-AF131933, and AF132510-AF132518.
KW  - amylases
KW  - DNA cloning
KW  - enzyme activity
KW  - hyaluronidase
KW  - molecular genetics
KW  - nucleotidase
KW  - proteins
KW  - salivary glands
KW  - Cimex lectularius
KW  - Diptera
KW  - Lutzomyia longipalpis
KW  - Phlebotominae
KW  - Psychodidae
KW  - Cimex
KW  - Cimicidae
KW  - Heteroptera
KW  - Hemiptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Lutzomyia
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - apyrase
KW  - bed bug
KW  - biochemical genetics
KW  - phosphodiesterase
KW  - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW  - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
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ER  - 

TY  - JOUR
T1  - Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum.
AU  - Deitsch, K. W.
AU  - Pinal, A. del
AU  - Wellems, T. E.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1999///
VL  - 101
IS  - 1/2
SP  - 107
EP  - 116
SN  - 0166-6851
AD  - Deitsch, K. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990805823.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Protozoology
N2  - Antigenic variation and immune evasion by Plasmodium falciparum parasitized erythrocytes are mediated by expression switches among members of the multicopy var gene family. A cluster of var genes on chromosome 12 is described that showed spontaneous recombination and switches in the transcription of individual genes. The transcription switches were not associated with sequence changes in promoter regions. Transfected episomes containing a luciferase reporter under control of a var promoter were expressed regardless of the transcriptional status of the endogenous promoter. The results suggest epigenetic regulation of var gene transcription in P. falciparum that depends on the local structure of chromatin and its associated proteins.
KW  - antigenic variation
KW  - antigens
KW  - chromatin
KW  - genes
KW  - immune evasion
KW  - luciferases
KW  - molecular genetics
KW  - parasites
KW  - proteins
KW  - recombination
KW  - reporter genes
KW  - transcription
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - antigenic polymorphism
KW  - antigenicity
KW  - biochemical genetics
KW  - DNA transcription
KW  - genetic recombination
KW  - immunogens
KW  - luciferase
KW  - reporter gene
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
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TY  - JOUR
T1  - Representational difference analysis of cDNA between two Dd2 clones of Plasmodium falciparum.
AU  - Soubes, S. C.
AU  - Liu Xuan
AU  - Miller, L. H.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1999///
VL  - 101
IS  - 1/2
SP  - 217
EP  - 221
SN  - 0166-6851
AD  - Soubes, S. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive, NIH, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990805877.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9001-67-6.  Subject Subsets: Protozoology
N2  - Complementary DNA-representational difference analysis (cDNA-RDA) was used to search for a messenger RNA encoding a Plasmodium falciparum ligand involved in an alternative pathway of cell invasion (sialic acid independent) expressed by the Dd2-Nm subpopulation of the Dd2 clone. Dd2-Nm parasites appear to grow at the same rate in neuraminidase-treated erythrocytes as in normal erythrocytes, whereas treatment of erythrocytes with neuraminidase to remove sialic acid leads to a 95% reduction in invasion by the Dd2 clone which has a sialic acid-dependent pathway of cell invasion. Although the cDNA-RDA method was not able to identify the gene responsible for the sialic acid-independent pathway, the method was found useful in identifying unique messages between 2 highly related clones of P. falciparum. Nucleotide sequence data have been submitted to the EMBL, GenBank and DDJB databases under accession numbers AF091994-AF091996.
KW  - cell invasion
KW  - clones
KW  - complementary DNA
KW  - erythrocytes
KW  - genes
KW  - host parasite relationships
KW  - identification
KW  - ligands
KW  - messenger RNA
KW  - molecular genetics
KW  - nucleotide sequences
KW  - parasites
KW  - sialidase
KW  - techniques
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - blood red cells
KW  - cDNA
KW  - DNA sequences
KW  - exo-alpha-sialidase
KW  - mRNA
KW  - neuraminidase
KW  - parasite host relationships
KW  - red blood cells
KW  - sialic acid
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805877&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification of additional members define a Plasmodium falciparum gene superfamily which includes Pfs48/45 and Pfs230.
AU  - Templeton, T. J.
AU  - Kaslow, D. C.
JO  - Molecular and Biochemical Parasitology
JF  - Molecular and Biochemical Parasitology
Y1  - 1999///
VL  - 101
IS  - 1/2
SP  - 223
EP  - 227
SN  - 0166-6851
AD  - Templeton, T. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990805878.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Subject Subsets: Protozoology
N2  - The Plasmodium falciparum surface protein Pfs230 and the protein doublet Pfs48/45 are encoded by a single gene and share a repeated 6-cys with a conserved cysteine structure. Three new members of the 6-cys domain gene superfamily were identified in the Malaria Genome Sequencing Project databases and the P. falciparum 6-cys gene superfamily currently contains 7 members: 5 within the Pfs48/45 family and 2 within the Pfs230 family. Six-cys domains were not identified outside of Plasmodium, suggesting that the domain is specific to the genus. The new Pfs48/45-related genes were named, based on the putative MW of the deduced mature protein, as Pf36, Pf41 and Pf47. Nucleotide sequences of the genes were confirmed by polymerase chain reaction amplification and sequencing from genomic DNA of the 3D7 strain of P. falciparum. Nucleotide sequence data have been submitted to GenBank under accession number AF132898.
KW  - genes
KW  - genomes
KW  - molecular genetics
KW  - molecular weight
KW  - nucleotide sequences
KW  - parasites
KW  - proteins
KW  - surface proteins
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - DNA sequences
KW  - membrane proteins
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805878&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Results of the National Cooperative Inner-City Asthma Study (NCICAS) environmental intervention to reduce cockroach allergen exposure in inner-city homes.
AU  - Gergen, P. J.
AU  - Mortimer, K. M.
AU  - Eggleston, P. A.
AU  - Rosenstreich, D.
AU  - Mitchell, H.
AU  - Ownby, D.
AU  - Kattan, M.
AU  - Baker, D.
AU  - Wright, E. C.
AU  - Slavin, R.
AU  - Malveaux, F.
JO  - Journal of Allergy and Clinical Immunology
JF  - Journal of Allergy and Clinical Immunology
Y1  - 1999///
VL  - 103
IS  - 3
SP  - 501
EP  - 506
SN  - 0091-6749
AD  - Gergen, P. J.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7640, USA.
N1  - Accession Number: 20000504716.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 71751-41-2.  Subject Subsets: Medical & Veterinary Entomology
N2  - The NCICAS intervention programme was conducted at 8 asthma study units located in 7 major metropolitan areas of the USA between 1 August and 31 October 1994. As part of this intervention, a combination of education, cleaning, and extermination with Avert (abamectin) was used in an attempt to decrease cockroach (Blattella germanica) allergen levels in the homes of 265 families who had participating asthmatic children with a positive skin test to cockroach allergen (n=515). House dust in the kitchen, bedroom and TV/living room of a random subset of 48 homes undergoing cockroach extermination treatment was collected in January, March, July and December of 1995 and analysed for Bla g 1. Samples were collected 1 week before extermination and 2, 6 and 12 months after intervention. In the kitchen the geometric mean decreased relative to preextermination levels after the 2-month visit (33.6 U/g. P&lt;0.05). The percent of kitchens with over 8 U/g of Bla g 1 was only significant from preextermination levels to 6-month levels (86.8 vs. 64.3%, P&lt;0.5). The geometric mean level of Bla g 1 increased in the bedroom between the preextermination and 2-month visits (8.9 vs. 11.1 U/g, P&lt;0.05). There was no significant difference in the number of cockroach stains measured in the kitchens during preextermination, 2-, 6, and 12-month visits. It was noted that ~50% households did not comply with the instructions to prepare for the extermination. There was no significant decrease in reported problems with cockroaches between intervention and control houses after 12 months.
KW  - abamectin
KW  - allergens
KW  - arthropod allergies
KW  - asthma
KW  - chemical control
KW  - dwellings
KW  - environmental management
KW  - intervention
KW  - sanitation
KW  - USA
KW  - Blattaria
KW  - Blattella germanica
KW  - man
KW  - Blattaria
KW  - Dictyoptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Blattella
KW  - Blattellidae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - avermectin B1
KW  - Blattodea
KW  - German cockroach
KW  - United States of America
KW  - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Environmental Pest Management (HH200) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000504716&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Organochlorines in breast milk from two cities in Ukraine.
AU  - Gladen, B. C.
AU  - Monaghan, S. C.
AU  - Lukyanova, E. M.
AU  - Hulchiy, O. P.
AU  - Shkyryak-Nyzhnyk, Z. A.
AU  - Sericano, J. L.
AU  - Little, R. E.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1999///
VL  - 107
IS  - 6
SP  - 459
EP  - 462
SN  - 0091-6765
AD  - Gladen, B. C.: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 20000403551.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 72-55-9, 50-29-3, 60-57-1, 72-20-8, 608-73-1, 76-44-8, 118-74-1.  Subject Subsets: Dairy Science; Human Nutrition
N2  - Reports of environmental problems in the former USSR, including excess use of pesticides, have led to concerns about high levels of contamination in humans, but little information is available to assess whether these concerns are warranted. Samples of milk from 197 women from 2 cities in the Ukraine were analysed for p,p′-DDT, p,p′-DDE, endrin, dieldrin, heptachlor epoxide, trans-nonachlor, oxychlordane, hexachlorobenzene, β-hexachlorocyclohexane (HCH), and 18 polychlorinated biphenyl congeners, and results were compared with reports from Europe. The median β-HCH concentration was 731 ng/g milk fat, which is higher than other reports from Europe but lower than reports from other parts of the world. The median DDE concentration was 2,457 ng/g milk fat, which is higher than most, but not all, other reports from Europe. Concentrations of other pesticides were comparable with, or lower than, other reports from Europe. Concentrations from the city of Kyiv were lower than those from Dniprodzerzhinsk, but the differences were small.
KW  - congeners
KW  - contamination
KW  - DDE
KW  - DDT
KW  - dieldrin
KW  - endrin
KW  - HCH
KW  - heptachlor
KW  - hexachlorobenzene
KW  - human milk
KW  - milk fat
KW  - pesticide residues
KW  - pesticides
KW  - polychlorinated biphenyls
KW  - women
KW  - Europe
KW  - Ukraine
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central Europe
KW  - Europe
KW  - Developed Countries
KW  - benzene hexachloride
KW  - BHC
KW  - breast milk
KW  - butterfat
KW  - dicophane
KW  - HCB
KW  - nonachlor
KW  - oxychlordane
KW  - p,p'-dichlorodiphenyldichloroethylene
KW  - PCBs
KW  - Milk and Dairy Produce (QQ010) 
KW  - Physiology of Human Nutrition (VV120) 
KW  - Human Toxicology and Poisoning (VV810) (New March 2000)
KW  - Food Contamination, Residues and Toxicology (QQ200) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Medicinal herbs in the United States: research needs.
AU  - Matthews, H. B.
AU  - Lucier, G. W.
AU  - Fisher, K. D.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1999///
VL  - 107
IS  - 10
SP  - 773
EP  - 778
SN  - 0091-6765
AD  - Matthews, H. B.: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 20000308940.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Subject Subsets: Horticultural Science
N2  - Medicinal herbs have played a major role in the development of modern medicine and continue to be widely used in their original form. Whereas it is generally agreed that most medicinal herbs are safe under the conditions used, some are toxic and should be avoided even though they are readily available, and others have significant adverse side effects when misused. Little work has been done to investigate potential adverse effects that may be associated with extended or high-dose use of medicinal herbs. Concern has been expressed that the lack of quality control used in the preparation of medicinal herbs, plus their unregulated sale and uninformed use, pose potential adverse health effects for consumers. There is also concern regarding potential herb/herb or herb/drug interactions and possible untoward health effects of medicinal herbs in sensitive subpopulations such as the young and the elderly and certain genetically predisposed individuals. These concerns are discussed at some length. Recommendations for additional research and education with reference to USA are discussed.
KW  - adverse effects
KW  - control
KW  - drug interactions
KW  - guidelines
KW  - health
KW  - herbal drugs
KW  - medicinal plants
KW  - quality controls
KW  - regulations
KW  - safety
KW  - toxicity
KW  - toxicology
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - drug plants
KW  - herbal medicines
KW  - medicinal herbs
KW  - officinal plants
KW  - quality assurance
KW  - recommendations
KW  - rules
KW  - United States of America
KW  - Plant Composition (FF040) 
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Laws and Regulations (DD500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Temperature and air pollution as risk factors for heat stroke in Tokyo, July and August 1980-1995.
AU  - Piver, W. T.
AU  - Ando, M.
AU  - Ye, F.
AU  - Portier, C. J.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1999///
VL  - 107
IS  - 11
SP  - 911
EP  - 916
CY  - Research Triangle Park; USA
PB  - National Institute of Environmental Health Sciences
SN  - 0091-6765
AD  - Piver, W. T.: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
N1  - Accession Number: 20003025362.  Publication Type: Journal Article.  Language: English.  Number of References: 27 ref. Subject Subsets: Public Health; Soils & Fertilizers
N2  - Heat stroke is associated with prolonged exposures to high air temperatures that usually occur in the summer months of July and August in Tokyo, Japan. Also during July and August, residents of Tokyo are often exposed simultaneously to high concentrations of air pollutants. To assess the impacts of these combined exposures, daily numbers of heat stroke emergency transport cases/million residents for Tokyo were stratified by gender and three groups: 0-14, 15-64, and &gt;65 years of age, for the months of July and August in 1980-1995. A regression model was constructed using daily maximum temperature (Tmax) and daily average concentrations of NO2 and O3 as model covariates. Classification indices were added to make it possible to compare the expected number of heat stroke cases by age and gender. Lag times of 1-4 days in Tmax and air quality covariates and terms to account for interactions between pairs of model covariates were also included as additional risk factors. Generalized linear models (GLMs), assuming a Poisson error structure for heat stroke emergency transport cases, were used to determine which covariates were significant risk factors for heat stroke for the three age groups of males and females. Same-day Tmax and concentrations of NO2 were the most significant risk factors for heat stroke in all age groups of males and females. The number of heat stroke emergency transport cases/million residents was greater in males than in females in the same age groups. The smallest number of heat stroke emergency transport cases/million residents occurred for females 0-14 years of age and the greatest number of heat stroke emergency transport cases/million residents occurred for males &gt;65 years of age.
KW  - air pollutants
KW  - air pollution
KW  - risk factors
KW  - temperature
KW  - Honshu
KW  - Japan
KW  - Japan
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - atmospheric pollution
KW  - Pollution and Degradation (PP600) 
KW  - Human Health and the Environment (VV500) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of a multicopy family of genes encoding a surface-expressed serine endoprotease in rat Pneumocystis carinii.
AU  - Russian, D. A.
AU  - Andrawis-Sorial, V.
AU  - Goheen, M. P.
AU  - Edman, J. C.
AU  - Vogel, P.
AU  - Turner, R. E.
AU  - Klivington, D. L.
AU  - Angus, C. W.
AU  - Kovacs, J. A.
JO  - Proceedings of the Association of American Physicians
JF  - Proceedings of the Association of American Physicians
Y1  - 1999///
VL  - 111
IS  - 4
SP  - 347
EP  - 356
AD  - Russian, D. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1662, USA.
N1  - Accession Number: 20001202069.  Publication Type: Journal Article.  Language: English.  Number of References: 22 ref. Registry Number: 56-45-1.  Subject Subsets: Medical & Veterinary Mycology
N2  - The characterization of a unique family of genes encoding serine endoproteases related to the Saccharomyces cerevisiae serine endoprotease kexin was identified in P. carinii. Unlike previously described serine endoprotease genes that are single copies, multiple copies of the P. carinii serine endoprotease are distributed throughout the genome. The proteins predicted by these variant genes demonstrate sequence variability, but they retain the conserved active sites associated with endoprotease activity. The serine endoprotease was localized to the organism surface by immunohistochemical and immunofluorescence studies and to the electron lucent layer of the cyst wall by immunoelectron microscopy. The findings of multiple copies of the serine endoprotease gene in the P. carinii genome, and its localization to the cell surface, suggest that this protease plays an important role in the biology of P. carinii and that antigenic variation of the surface-expressed serine endoprotease may be a strategy for immune evasion.
KW  - antigens
KW  - genes
KW  - genetics
KW  - genomes
KW  - immunohistochemistry
KW  - proteinases
KW  - proteins
KW  - serine
KW  - serine proteinases
KW  - fungi
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis
KW  - Pneumocystis carinii
KW  - rats
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - eukaryotes
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - Pneumocystis
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - antigenicity
KW  - fungus
KW  - immunogens
KW  - proteases
KW  - serine proteases
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202069&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Prevalence and ethnic differences in gallbladder disease in the United States.
AU  - Everhart, J. E.
AU  - Meena Khare
AU  - Hill, M.
AU  - Maurer, K. R.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1999///
VL  - 117
IS  - 3
SP  - 632
EP  - 639
SN  - 0016-5085
AD  - Everhart, J. E.: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Natcher Building, Room 6AN-12J, 45 Center Drive, MSC 6600, Bethesda, Maryland 20892-6600, USA.
N1  - Accession Number: 19992012477.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Subject Subsets: Public Health
N2  - A national population-based survey was performed to determine the age, sex, and ethnic distribution of gall bladder disease in the USA. The third National Health and Nutrition Examination Survey (NHANES III) conducted gall bladder ultrasonography among a representative U.S. sample of &gt;14 000 persons. The diagnosis of gall bladder disease by detection of gallstones or cholecystectomy was made with excellent reproducibility. An estimated 6.3 million men and 14.2 million women aged 20-74 years had gall bladder disease. Age-standardized prevalence was similar for non-Hispanic white (8.6%) and Mexican American (8.9%) men, and both were higher than non-Hispanic black men (5.3%). These relationships persisted with multivariate adjustment. Among women, age-adjusted prevalence was highest for Mexican Americans (26.7%) followed by non-Hispanic whites (16.6%) and non-Hispanic blacks (13.9%). Among women, multivariate adjustment reduced the risk of gall bladder disease for both Mexican Americans and non-Hispanic blacks compared with non-Hispanic whites.
KW  - biliary calculi
KW  - Blacks
KW  - disease prevalence
KW  - epidemiology
KW  - ethnic groups
KW  - ethnicity
KW  - gall bladder
KW  - gall bladder diseases
KW  - Hispanics
KW  - human diseases
KW  - risk factors
KW  - sex
KW  - sex differences
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - ethnic differences
KW  - gallstones
KW  - United States of America
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Resolution of chronic delta hepatitis after 12 years of interferon alfa therapy.
AU  - Lau, D. T. Y.
AU  - Kleiner, D. E.
AU  - Park, Y.
AU  - Bisceglie, A. M. di
AU  - Hoofnagle, J. H.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1999///
VL  - 117
IS  - 5
SP  - 1229
EP  - 1233
SN  - 0016-5085
AD  - Lau, D. T. Y.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
N1  - Accession Number: 20002005679.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 9008-11-1.  Subject Subsets: Public Health
N2  - A 42-year-old patient with chronic delta hepatitis, referred to the Liver Diseases Section of the National Institutes of Health in Maryland, USA in April 1983, was treated with interferon-α (Intron-A; 5 million units daily) for 12 years. Serial serum samples were analysed by routine liver tests and selected samples examined for quantitative levels of hepatitis B surface antigen (HBsAg) and hepatitis delta virus RNA. Liver biopsies were performed before, during and after an initial one-year course of therapy and again after 3 and 10 years of continuous therapy. With initiation of interferon therapy, serum aminotransferase levels decreased to normal range, became abnormal again when the dose was reduced, and increased to pretreatment levels when therapy was stopped. With reinstitution and prolonged therapy, aminotransferase levels became persistently normal and after several years, both hepatitis delta virus RNA and serum HBsAg became undetectable. Liver biopsy, which initially revealed cirrhosis, showed gradual improvement in inflammatory and fibrosis scores and, after 10 years, no abnormalities or fibrosis. Therapy was stopped and the patient remained free of evidence of infection. It is concluded that long-term therapy with interferon-α in high doses led to resolution of chronic delta hepatitis, disappearance of hepatitis delta and B virus markers and improvement in fibrosis.
KW  - case reports
KW  - cirrhosis
KW  - drug therapy
KW  - fibrosis
KW  - hepatitis B
KW  - hepatitis D
KW  - human diseases
KW  - interferon
KW  - liver diseases
KW  - Maryland
KW  - USA
KW  - hepatitis B virus
KW  - hepatitis delta virus
KW  - man
KW  - Hepadnaviridae
KW  - DNA Reverse Transcribing Viruses
KW  - viruses
KW  - Deltavirus
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - liver cirrhosis
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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TY  - JOUR
T1  - Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate.
AU  - Baumert, T. F.
AU  - Vergalla, J.
AU  - Satoi, J.
AU  - Thomson, M.
AU  - Lechmann, M.
AU  - Herion, D.
AU  - Greenberg, H. B.
AU  - Ito, S.
AU  - Liang, T. J.
JO  - Gastroenterology
JF  - Gastroenterology
Y1  - 1999///
VL  - 117
IS  - 6
SP  - 1397
EP  - 1407
SN  - 0016-5085
AD  - Baumert, T. F.: Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 20002009708.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref.
N2  - The generation of hepatitis C virus (HCV)-like particles (HCV-LPs) in insect cells using a recombinant baculovirus containing the complementary DNA of the HCV structural proteins has been previously described. These HCV-LPs had similar morphological and biophysical properties as the putative virions. In this study, the structural features, antigenic composition, seroreactivity, and immunogenicity of purified HCV-LPs were analysed. HCV-LPs were analysed by electron microscopy and antibody immunolabelling and precipitation. An ELISA using HCV-LPs was developed. The humoral response to HCV-LPs in mice was studies by core and envelope ELISAs, Western immunoblotting, and immunofluorescence. Structural and antigenic compositions of HCV-LPs were shown to be similar to those of putative HCV virions. Using the HCV-LP ELISA, high-titre anti-HCV antibodies were detected in individuals infected with various HCV genotypes. In vivo, HCV-LPs elicited a humoral response broadly directed against HCV structural proteins. It is concluded that HCV-LPs resemble HCV virions and are capable of inducing a humoral response targeted against various regions of HCV structural proteins, suggesting that HCV-LPs may be promising as a potential vaccine candidate.
KW  - hepatitis C
KW  - human diseases
KW  - immune response
KW  - vaccine development
KW  - vaccines
KW  - viral structural proteins
KW  - virus-like particles
KW  - hepatitis C virus
KW  - man
KW  - mice
KW  - Hepacivirus
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - immunity reactions
KW  - immunogenicity
KW  - immunological reactions
KW  - Host Resistance and Immunity (HH600) 
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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ER  - 

TY  - JOUR
T1  - Low-grade monoclonal Epstein-Barr virus-associated lymphoproliferative disorder of the brain presenting as human immunodeficiency virus-associated encephalopathy in a child with acquired immunodeficiency syndrome.
AU  - Kingma, D. W.
AU  - Mueller, B. U.
AU  - Frekko, K.
AU  - Sorbara, L. R.
AU  - Wood, L. V.
AU  - Katz, D.
AU  - Raffeld, M.
AU  - Jaffe, E. S.
JO  - Archives of Pathology and Laboratory Medicine
JF  - Archives of Pathology and Laboratory Medicine
Y1  - 1999///
VL  - 123
IS  - 1
SP  - 83
EP  - 87
SN  - 0003-9985
AD  - Kingma, D. W.: Hematopathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-1500, USA.
N1  - Accession Number: 19992005011.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref.
N2  - A case is reported of an 8-year-old HIV-positive girl from the USA, who developed a lesion in the central nervous system that appeared to be histologically reactive and that proved to be an Epstein-Barr virus-associated monoclonal B-cell lymphoproliferative disorder by molecular analysis. The patient was diagnosed with vertically transmitted HIV infection at age 5, for which she was treated empirically with a combination of zidovudine and didanosine. At the age of 7 years, during evaluation for entry into an antiretroviral protocol, a single hypodense frontal lobe lesion was identified by computed tomography. After unsuccessful treatment for presumed toxoplasmosis and progressive neurological deterioration, a stereotactic brain biopsy was performed. Although the biopsy contained a polymorphic lymphoid infiltrate that appeared to be cytologically reactive, polymerase chain reaction and in situ hybridization studies revealed a monoclonal Epstein-Barr virus-associated B-cell lymphoproliferative disorder, which was reminiscent of polymorphic B-cell hyperplasia observed in the setting of immunosuppression following organ transplantation. Postoperative therapy included steroids and antiretroviral therapy. The lesion decreased slightly in size, and the child's neurological status was relatively unremarkable for 5 months. Subsequently, she developed cytomegalovirus retinitis, progressive encephalopathy and died with pancytopenia.
KW  - acquired immune deficiency syndrome
KW  - brain
KW  - case reports
KW  - children
KW  - clinical aspects
KW  - diagnosis
KW  - encephalopathy
KW  - girls
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - mixed infections
KW  - opportunistic infections
KW  - viral diseases
KW  - USA
KW  - Human herpesvirus 4
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Lymphocryptovirus
KW  - Gammaherpesvirinae
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Human herpesvirus 4
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - cerebrum
KW  - clinical picture
KW  - Epstein-Barr virus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - multiple infections
KW  - United States of America
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Progressive multifocal leukoencephalopathy and JC virus genotypes in West African patients with acquired immunodeficiency syndrome: a pathologic and DNA sequence analysis of 4 cases.
AU  - Chima, S. C.
AU  - Agostini, H. T.
AU  - Ryschkewitsch, C. F.
AU  - Lucas, S. B.
AU  - Stoner, G. L.
JO  - Archives of Pathology and Laboratory Medicine
JF  - Archives of Pathology and Laboratory Medicine
Y1  - 1999///
VL  - 123
IS  - 5
SP  - 395
EP  - 403
SN  - 0003-9985
AD  - Chima, S. C.: Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992007058.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Tropical Diseases
N2  - Cases of progressive multifocal leukoencephalopathy are reported in 4 HIV-positive patients from Côte d'Ivoire, and the viral genotypes are analysed. Immunohistochemical staining by labelled streptavidin-biotin for capsid protein antigen was performed on all cases. Polymerase chain reaction amplification of viral genomic DNA was followed by direct cycle sequencing. JC virus type 3 was identified in 2 cases, and type 6 was isolated in 1 case. The viral regulatory region from 1 case showed an uncommon rearrangement pattern. It is concluded that progressive multifocal leukoencephalopathy in West African patients with AIDS is caused by African genotypes of JC virus (types 3 and 6). The prevalence of disease in this postmortem examination series from sub-Saharan Africa (1.5%) was less than has been reported from Europe and the United States (4-10%) and it is suggested that this may be partly due to biological differences in JC virus genotypes.
KW  - acquired immune deficiency syndrome
KW  - case reports
KW  - encephalitis
KW  - encephalopathy
KW  - genetics
KW  - genotypes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - opportunistic infections
KW  - pathology
KW  - progressive multifocal leukoencephalopathy
KW  - viral diseases
KW  - Cote d'Ivoire
KW  - JC polyomavirus
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Polyomavirus
KW  - Polyomaviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Developing Countries
KW  - Francophone Africa
KW  - Africa
KW  - West Africa
KW  - Africa South of Sahara
KW  - AIDS
KW  - encephalomyelitis
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Ivory Coast
KW  - JC virus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels.
AU  - Mahmoodian, F.
AU  - Peterkofsky, B.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999///
VL  - 129
IS  - 1
SP  - 83
EP  - 91
SN  - 0022-3166
AD  - Mahmoodian, F.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 20001410520.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 50-81-7, 61912-98-9.  Subject Subsets: Human Nutrition
N2  - Ascorbic acid deficiency causes morphologic changes in the endothelial and smooth muscle compartments of guinea pig blood vessels. Endothelial cells synthesize the basement membrane components, type IV collagen and laminin, and smooth muscle cells synthesize elastin in blood vessels. Therefore, the possibility that ascorbic acid deficiency affects the expression of these proteins was examined. Decreased expression of types I and II collagens in other tissues of ascorbic acid-deficient guinea pigs is associated with weight loss and the consequent induction of insulin-like growth factor binding proteins; thus food deprivation to induce weight loss was used also. Female guinea pigs received a ascorbic acid-free diet, supplemented orally with ascorbate. Ascorbic acid-deficient guinea pigs received the same diet but no ascorbate, and the food-deprived group received no food, but were supplemented with ascorbic acid. Concentrations of mRNAs for basement membrane components and elastin in blood vessels were measured by Northern blotting; overall basement membrane metabolism was assessed by measuring immunoreactive laminin and type IV 7S collagen in serum. Laminin mRNA in blood vessels and serum laminin concentrations were unaffected by ascorbic acid deficiency. Concentrations of type IV collagen and elastin mRNAs in blood vessels were not affected in moderately scorbutic guinea pigs (0-7% weight loss), but with increased weight loss, type IV collagen mRNA was 57% (P&lt;0.05) and elastin mRNA was 3% (P&lt;0.01) of normal values. In food-deprived guinea pigs, type IV collagen mRNA was 51% (P&lt;0.05) and elastin mRNA was 35% (P&lt;0.05) of normal. Serum type IV 7S collagen concentrations were 25% of normal in scorbutic guinea pigs with extensive weight loss. The lower expression of type IV collagen and elastin mRNAs in blood vessels may contribute to defects observed in blood vessels during scurvy.
KW  - ascorbic acid
KW  - binding proteins
KW  - blood vessels
KW  - collagen
KW  - deficiency
KW  - deficiency diseases
KW  - deprivation
KW  - endothelium
KW  - food deprivation
KW  - growth factors
KW  - insulin-like growth factor
KW  - messenger RNA
KW  - muscles
KW  - scurvy
KW  - supplements
KW  - weight losses
KW  - guineapigs
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - carrier proteins
KW  - guinea pigs
KW  - mRNA
KW  - somatomedin C
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Vitamin A-sensitive tissues in transgenic mice expressing high levels of human cellular retinol-binding protein type I are not altered phenotypically.
AU  - Trøen, G.
AU  - Eskild, W.
AU  - Fromm, S. H.
AU  - Luca, L. M. de
AU  - Ong, D. E.
AU  - Wardlaw, S. A.
AU  - Reppe, S.
AU  - Blomhoff, R.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999///
VL  - 129
IS  - 9
SP  - 1621
EP  - 1627
SN  - 0022-3166
AD  - Trøen, G.: Institute for Nutrition Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
N1  - Accession Number: 20001416826.  Publication Type: Journal Article.  Language: English.  Registry Number: 68-26-8.  Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2  - The suggested function of cellular retinol-binding protein type I [CRBP(I)] is to carry retinol to esterifying or oxidizing enzymes. The retinyl esters are used in storage or transport, whereas oxidized forms such as all-trans or 9-cis retinoic acid are metabolites used in the mechanism of action of vitamin A. Thus, high expression of human CRBP(I) [hCRBP(I)] in transgenic mice might be expected to increase the production of retinoic acid in tissues, thereby inducing a phenotype resembling vitamin A toxicity. Alternatively, a vitamin A-deficient phenotype could also be envisioned as a result of an increased accumulation of vitamin A in storage cells induced by a high hCRBP(I) level. Signs of vitamin A toxicity or deficiency were therefore examined in tissues from transgenic mice with ectopic expression of hCRBP(I). Testis and intestine, the tissues with the highest expression of the transgene, showed normal gross morphology. Similarly, no abnormalities were observed in other tissues known to be sensitive to vitamin A status such as cornea and retina, and the epithelia in the cervix, trachea and skin. Furthermore, hematologic variables known to be influenced by vitamin A status as the hemoglobin concentration, haematocrits and the number of red blood cells were within normal ranges in the transgenic mice. In conclusion, these transgenic mice have normal function of vitamin A despite high expression of hCRBP(I) in several tissues.
KW  - binding proteins
KW  - genetically engineered organisms
KW  - phenotypes
KW  - retinol
KW  - tissues
KW  - transgenic animals
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - axerophthol
KW  - carrier proteins
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GEOs
KW  - GMOs
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Recent advances in varicella-zoster virus infection.
AU  - Cohen, J. I.
AU  - Brunell, P. A.
AU  - Straus, S. E.
AU  - Krause, P. R.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1999///
VL  - 130
IS  - 11
SP  - 922
EP  - 932
SN  - 0003-4819
AD  - Cohen, J. I.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1888, USA.
N1  - Accession Number: 19992009697.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 104 ref. Subject Subsets: Public Health
N2  - An edited summary of a Clinical Staff Conference held on 27 May 1998 at the National Institutes of Health, Bethesda, Maryland, USA, is presented. The molecular biology and immunology of varicella-zoster virus (VZV) including transmission, clinical features and diagnosis of varicella and zoster, management of varicella, zoster and postherpetic neuralgia, and prevention of varicella and zoster are reviewed.
KW  - clinical aspects
KW  - diagnosis
KW  - drug therapy
KW  - herpes zoster
KW  - human diseases
KW  - immunology
KW  - molecular biology
KW  - pathogenesis
KW  - prevention
KW  - reviews
KW  - shingles
KW  - transmission
KW  - viral diseases
KW  - Human herpesvirus 3
KW  - man
KW  - viruses
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Varicellovirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - clinical picture
KW  - neuralgia
KW  - varicella-zoster virus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasma HIV viral load in patients with hemophilia and late-stage HIV disease: a measure of current immune suppression.
AU  - Engels, E. A.
AU  - Rosenberg, P. S.
AU  - O'Brien, T. R.
AU  - Goedert, J. J.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1999///
VL  - 131
IS  - 4
SP  - 256
EP  - 264
SN  - 0003-4819
AD  - Engels, E. A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8005, Rockville, MD 20822, USA.
N1  - Accession Number: 19992012017.  Publication Type: Journal Article.  Corporate Author: Multicenter Hemophilia Cohort Study Language: English.  Number of References: 36 ref. Subject Subsets: Public Health
N2  - A retrospective cohort study was conducted to evaluate the relation between plasma HIV viral load and subsequent risk for disease progression in patients with late-stage HIV disease. 389 patients with haemophilia and late-stage HIV disease (CD4 count&lt;200 cells/mm³) at 16 treatment centres for patients with haemophilia in the USA and Europe were included in the study. Plasma HIV viral load was measured at baseline. Patients were followed for AIDS-related illnesses (primary outcome) and, specifically, Pneumocystis carinii pneumonia (secondary outcome). HIV viral load strongly predicted AIDS-related illness. For patients with viral loads &lt;4.00 log10 copies/ml, the one-year actuarial risk was 0% and the 5-year risk was 25%. For patients with viral loads of ≥6.00 log10 copies/ml, the one-year actuarial risk was 42% and the 5-year risk was 78%. A linear relation existed between viral load and risk for AIDS-related illness (hazard ratio, 2.37 per log10 copies/ml; P&lt;0.001). In addition, viral load most strongly predicted risk for illness immediately after viral load testing; this predictive relation attenuated over time (P=0.002). These findings changed little after adjustment for CD4 cell counts that were updated during follow-up. In the first year after viral load was measured, it predicted occurrence of P. carinii pneumonia (hazard ratio, 4.69 per log10 copies/ml; P&lt;0.001). It is concluded that in patients with haemophilia and late-stage HIV disease, viral load predicts disease progression independently of CD4 cell counts. Because viral load most strongly predicts progression immediately after load is measured, it seems to reflect the current level of immunosuppression.
KW  - acquired immune deficiency syndrome
KW  - disease course
KW  - haemophilia
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunosuppression
KW  - Pneumocystis carinii pneumonia
KW  - prognosis
KW  - viral load
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - AIDS
KW  - disease progression
KW  - fungus
KW  - hemophilia
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Randomized trial of "slow" versus "fast" feed advancements on the incidence of necrotizing enterocolitis in very low birth weight infants.
AU  - Rayyis, S. F.
AU  - Ambalavanan, N.
AU  - Wright, L.
AU  - Carlo, W. A.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1999///
VL  - 134
IS  - 3
SP  - 293
EP  - 297
SN  - 0022-3476
AD  - Rayyis, S. F.: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, and National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
N1  - Accession Number: 19991407068.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Subject Subsets: Human Nutrition
N2  - The hypothesis that in very low birth weight (VLBW) infants, slow feed advancement (15 cc/kg per day) would decrease the overall incidence of necrotizing enterocolitis (NEC) compared with fast feed advancement (35 cc/kg per day) was tested in a randomized controlled trial. 185 formula fed infants with birth weights ranging from 501-1500 g and gestational age ≤34 weeks were randomized to either the fast or slow feeding protocols using Similac Special Care (20 cal/oz). The incidence of NEC was not significantly different between the groups (Bell stage≥II, slow 13%, fast 9%, Bell stage III (perforation) slow 4%, fast 2%). It is concluded that a doubling in the rate of feed advancement in pre-term low birth weight infants did not affect the incidence of NEC, but did cause infants to regain their birth weight earlier.
KW  - clinical trials
KW  - enteral feeding
KW  - enterocolitis
KW  - infants
KW  - low birth weight infants
KW  - neonatal necrotizing enterocolitis
KW  - premature infants
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - United States of America
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Viral infections in interferon-γ receptor deficiency.
AU  - Dorman, S. E.
AU  - Uzel, G.
AU  - Roesler, J.
AU  - Bradley, J. S.
AU  - Bastian, J.
AU  - Billman, G.
AU  - King, S.
AU  - Filie, A.
AU  - Schermerhorn, J.
AU  - Holland, S. M.
JO  - Journal of Pediatrics
JF  - Journal of Pediatrics
Y1  - 1999///
VL  - 135
IS  - 5
SP  - 640
EP  - 643
SN  - 0022-3476
AD  - Dorman, S. E.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institues of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 20002005056.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Subject Subsets: Public Health
N2  - Cases of severe viral infections are reported in 4 patients [USA] with interferon-α (IFN-α) receptor deficiency and mycobacterial disease [date not given]. The mycobacterial pathogens included Mycobacterium avium, M. fortuitum and M. kansasii and the viral pathogens included respiratory syncytial virus, herpes simplex virus, parainfluenza virus type 3 and varicella-zoster virus. It is concluded that although disseminated infection with non-tuberculous mycobacteria is the most common clinical presentation of IFN-α receptor deficiency, the frequency and severity of viral infections may also be increased in patients with this primary immunodeficiency. IFN-α receptor deficiency should be included in the differential diagnosis in children with severe viral infections.
KW  - herpes simplex
KW  - herpes simplex viruses
KW  - human diseases
KW  - human herpesviruses
KW  - immunocompromised hosts
KW  - immunological deficiency
KW  - mycobacterial diseases
KW  - opportunistic infections
KW  - varicella
KW  - viral diseases
KW  - USA
KW  - Human herpesvirus 3
KW  - human respiratory syncytial virus
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium avium
KW  - Mycobacterium fortuitum
KW  - Mycobacterium kansasii
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Varicellovirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Pneumovirus
KW  - Paramyxoviridae
KW  - Mononegavirales
KW  - negative-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - Pneumovirinae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - Paramyxovirinae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - chicken pox
KW  - herpes simplex virus
KW  - Human herpesvirus
KW  - immune deficiency
KW  - immunodeficiency
KW  - mycobacterial infections
KW  - parainfluenza 3 virus
KW  - United States of America
KW  - varicella-zoster virus
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Dietary factors and the risk of gastric cancer in Mexico City.
AU  - Ward, M. H.
AU  - López Carrillo, L.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1999///
VL  - 149
IS  - 10
SP  - 925
EP  - 932
SN  - 0002-9262
AD  - Ward, M. H.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD., USA.
N1  - Accession Number: 19991410382.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Human Nutrition; Dairy Science
N2  - A population-based case-control study of gastric cancer in the metropolitan area of Mexico City was carried out in 1989-1990. 220 patients with histologically confirmed gastric adenocarcinomas were interviewed. Controls were an age-stratified random sample of residents of Mexico City. The dietary questionnaire was a 70-item semi-quantitative food frequency adapted for the Mexican diet. Odds ratios were calculated for quartiles of consumption of food groups and were adjusted for age, gender, calories, chilli pepper intake, cigarette smoking, socioeconomic status, added salt, and history of peptic ulcer disease. There was approximately a threefold increased risk of gastric cancer for frequent consumption (highest quartile) of both fresh meat (odds ratio (OR) = 3.1) and processed meat (OR = 3.2). Odds ratios were also significantly increased for frequent consumption of milk products (OR = 2.7) and fish (OR = 2.2). There was a decreasing gradient of risk with increasing frequency of vegetable consumption due to a significant inverse trend for the yellow and orange vegetables. High intake of citrus fruits showed a slight inverse association. Consumption of salty snacks more than twice per month was associated with an 80% increased risk, and there was a significant positive trend. These findings are consistent with many studies around the world that indicate important roles for salt, processed meats, and vegetable consumption in gastric cancer risk.
KW  - chillies
KW  - diet
KW  - diet studies
KW  - dietary history
KW  - digestive tract
KW  - intake
KW  - meat
KW  - milk products
KW  - neoplasms
KW  - processed products
KW  - risk
KW  - risk factors
KW  - salt
KW  - socioeconomic status
KW  - stomach
KW  - tobacco smoking
KW  - ulcers
KW  - vegetables
KW  - Mexico
KW  - Capsicum
KW  - man
KW  - Solanaceae
KW  - Solanales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developing Countries
KW  - Latin America
KW  - America
KW  - North America
KW  - OECD Countries
KW  - Threshold Countries
KW  - cancers
KW  - dairy products
KW  - food history
KW  - gastrointestinal tract
KW  - vegetable crops
KW  - Diet Studies (VV110) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Milk and Dairy Produce (QQ010) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer.
AU  - Cantor, K. P.
AU  - Lynch, C. F.
AU  - Hildesheim, M. E.
AU  - Dosemeci, M.
AU  - Lubin, J.
AU  - Alavanja, M.
AU  - Craun, G.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1999///
VL  - 150
IS  - 6
SP  - 552
EP  - 560
SN  - 0002-9262
AD  - Cantor, K. P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8106, Bethesda, MD 20892-7240, USA.
N1  - Accession Number: 20002007919.  Publication Type: Journal Article.  Language: English.  Number of References: 40 ref. Registry Number: 7782-50-5. 
N2  - The authors conducted a population-based case-control study in Iowa, USA of 375 brain cancer patients and 2434 controls. A postal questionnaire was used to gather information on lifetime residential history, sources of drinking water, beverage intake, and other potential risk factors. Exposure to chlorination byproducts in drinking water was estimated by combining questionnaire data with historical information from water utilities and trihalomethane levels in recent samples. The analysis included 291 cases (77.6%) and 1983 controls (81.5%), for whom water quality information was available for at least 70% of lifetime years. Proxies represented 74.4% of cases. The mean number and mean duration of places of residence were comparable between direct and proxy respondents, suggesting little contribution to bias. After multivariate adjustment, odds ratios for brain cancer were 1.0, 1.1, 1.6, and 1.3 for exposure to chlorinated surface water of 0, 1-19, 20-39, and ≥40 years (p trend = 0.1). Among men, odds ratios were 1.0, 1.3, 1.7 and 2.5 (p trend = 0.04), and among women, 1.0, 1.0, 1.6, and 0.7 (p trend = 0.7). Similar findings were found with estimates of average lifetime level of trihalomethanes. The association was stronger among men with above-median tap water consumption. These observations deserve further attention, especially in view of increasing glioma rates.
KW  - brain
KW  - chlorination
KW  - chlorine
KW  - drinking water
KW  - human diseases
KW  - men
KW  - neoplasms
KW  - risk factors
KW  - women
KW  - Iowa
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Corn Belt States of USA
KW  - North Central States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - West North Central States of USA
KW  - cancers
KW  - cerebrum
KW  - trihalomethanes
KW  - United States of America
KW  - Water Resources (PP200) 
KW  - Human Health and the Environment (VV500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007919&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Implications of a new dietary measurement error model for estimation of relative risk: application to four calibration studies.
AU  - Kipnis, V.
AU  - Carroll, R. J.
AU  - Freedman, L. S.
AU  - Li Li
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1999///
VL  - 150
IS  - 6
SP  - 642
EP  - 651
SN  - 0002-9262
AD  - Kipnis, V.: Biometry Branch, Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Room 344, 6130 Executive Blvd., MSC 7354, Bethesda, MD 20892-7354, USA.
N1  - Accession Number: 20001406251.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Subject Subsets: Human Nutrition
N2  - Food records or 24-h recalls are currently used to calibrate food frequency questionnaires (FFQ) and to correct disease risks for measurement error. The standard regression calibration approach requires that these reference measures contain only random within-person errors uncorrelated with errors in FFQ. Increasing evidence suggests that records/recalls are likely to be also flawed with systematic person-specific biases, so that for any individual the average of multiple replicate assessments may not converge to her/his true usual nutrient intake. A new measurement error model is proposed to accommodate person-specific bias in the reference measure and its correlation with systematic error in the FFQ. Sensitivity analysis using calibration data from 4 studies demonstrated that failure to account for person-specific bias in the reference measure can often lead to substantial underestimation of the relative risk for a nutrient. It is concluded that in the absence of information on the extent of person-specific biases in reference instruments and their relation to biases in FFQ, the adequacy of the standard methods of correcting relative risks for measurement error is in question, as is the interpretation of negative findings from nutritional epidemiology such as failure to detect an important relation between fat intake and breast cancer.
KW  - analytical methods
KW  - calibration
KW  - diet studies
KW  - diet study techniques
KW  - epidemiology
KW  - intake
KW  - nutrients
KW  - questionnaires
KW  - regression analysis
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - analytical techniques
KW  - Techniques and Methodology (ZZ900) 
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Epidemiology of rotavirus diarrhea in Egyptian children and implications for disease control.
AU  - Naficy, A. B.
AU  - Abu-Elyazeed, R.
AU  - Holmes, J. L.
AU  - Rao, M. R.
AU  - Savarino, S. J.
AU  - Kim YongDai
AU  - Wierzba, T. F.
AU  - Peruski, L.
AU  - Lee, Y. J.
AU  - Gentsch, J. R.
AU  - Glass, R. I.
AU  - Clemens, J. D.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1999///
VL  - 150
IS  - 7
SP  - 770
EP  - 777
SN  - 0002-9262
AD  - Naficy, A. B.: Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
N1  - Accession Number: 20002004780.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Subject Subsets: Tropical Diseases
N2  - A study was conducted to describe the epidemiology of rotavirus diarrhoea in a population-based cohort of children &lt;3 years of age residing in Abu Homos, Egypt, during 1995-96. Rotavirus diarrhoea incidence rates (episodes per person-year) were 0.13 for infants aged &lt;6 months, 0.61 for those aged 6-11 months, 0.17 for those aged 12-23 months and 0.15 for those aged 24-35 months. 56% of children with rotavirus diarrhoea had clinical dehydration; 90% of rotavirus diarrhoeal episodes occurred between July and November. In infants less than 1 year of age, receipt of breast milk was associated with a lower incidence of rotavirus diarrhoea. No other sociodemographic or environmental factor was significantly associated with rotavirus diarrhea. Of 46 rotavirus isolates with strains identified, 41 (89%) were G serotypes 1 and 2. Rotavirus diarrhoea was a major cause of morbidity in this cohort. It is suggested that promotion of breastfeeding may exert a protective effect in young infants in this setting, but improvements in water and sanitation are unlikely to be effective preventive measures. The use of effective immunization against rotavirus in early infancy should be considered a public health priority.
KW  - breast feeding
KW  - children
KW  - clinical aspects
KW  - diarrhoea
KW  - disease control
KW  - disease prevalence
KW  - epidemiology
KW  - human diseases
KW  - infants
KW  - morbidity
KW  - risk factors
KW  - seasonal variation
KW  - serotypes
KW  - strains
KW  - Egypt
KW  - man
KW  - Rotavirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Reoviridae
KW  - dsRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Developing Countries
KW  - Mediterranean Region
KW  - Middle East
KW  - North Africa
KW  - Africa
KW  - clinical picture
KW  - diarrhea
KW  - Misr
KW  - scouring
KW  - seasonal changes
KW  - seasonal fluctuations
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Longitudinal change in height of men and women: implications for interpretation of the body mass index. The Baltimore Longitudinal Study of Aging.
AU  - Sorkin, J. D.
AU  - Muller, D. C.
AU  - Andres, R.
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
Y1  - 1999///
VL  - 150
IS  - 9
SP  - 969
EP  - 977
SN  - 0002-9262
AD  - Sorkin, J. D.: Metabolism Section, Laboratory of Clinical Investigation, Intramural Research Program, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA.
N1  - Accession Number: 20001407568.  Publication Type: Journal Article.  Language: English.  Number of References: 11 ref. Subject Subsets: Human Nutrition
N2  - 2084 men and women aged 17-94 years enrolled from 1958 to 1993 in the Baltimore Longitudinal Study of Aging were studied. On average, men's height was measured 9 times during 15 years and women's height 5 times during 9 years. The rate of decrease in height was greater for women than for men. For both sexes, height loss began at about 30 years of age and accelerated with increasing age. Cumulative height loss from 30 to 70 years of age averaged about 3 cm for men and 5 cm for women; by 80 years of age, it increased to 5 cm for men and 8 cm for women. This degree of height loss would account for an "artefactual" increase in body mass index of approximately 0.7 kg/m² for men and 1.6 kg/m² for women by 70 years of age that increases to 1.4 and 2.6 kg/m², respectively, by 80 years of age. It is concluded that true height loss with aging must be taken into account when height (or indexes based on height) is used in physiologic or clinical studies.
KW  - aging
KW  - anthropometric dimensions
KW  - body weight
KW  - elderly
KW  - height
KW  - men
KW  - old age
KW  - sex differences
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - aged
KW  - ageing
KW  - anthropometric measurements
KW  - elderly people
KW  - older adults
KW  - senior citizens
KW  - Human Nutrition (General) (VV100) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Current approaches to diagnosis and treatment of fungal infections in children infected with human immuno deficiency virus.
AU  - Müller, F. M. C.
AU  - Groll, A. H.
AU  - Walsh, T. J.
JO  - European Journal of Pediatrics
JF  - European Journal of Pediatrics
Y1  - 1999///
VL  - 158
IS  - 3
SP  - 187
EP  - 199
SN  - 0340-6199
AD  - Müller, F. M. C.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991202018.  Publication Type: Journal Article.  Language: English.  Number of References: 111 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Current knowledge of epidemiology, clinical presentation, diagnosis and treatment of mucosal and invasive fungal infections in children and adolescents with human immunodeficiency virus is reviewed. Infections caused by Candida spp., Cryptococcus neoformans, Aspergillus spp., Histoplasma capsulatum, Coccidioides immitis, Penicillium marneffei, Pneumocystis carinii and other fungi are discussed.
KW  - adolescents
KW  - aspergillosis
KW  - candidosis
KW  - children
KW  - clinical aspects
KW  - coccidioidomycosis
KW  - cryptococcosis
KW  - diagnosis
KW  - drug therapy
KW  - epidemiology
KW  - histoplasmosis
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - infections
KW  - mycoses
KW  - opportunistic infections
KW  - pneumocystosis
KW  - predisposition
KW  - reviews
KW  - Aspergillus
KW  - Candida
KW  - Coccidioides immitis
KW  - Cryptococcus neoformans
KW  - Histoplasma capsulatum
KW  - man
KW  - Penicillium marneffei
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Ajellomyces
KW  - Ajellomycetaceae
KW  - Onygenales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Coccidioides
KW  - Onygenaceae
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - Histoplasma
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Penicillium
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ajellomyces capsulatus
KW  - candidiasis
KW  - chemotherapy
KW  - clinical picture
KW  - coccidiomycosis
KW  - european blastomycosis
KW  - fungus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Hyphomycetes
KW  - teenagers
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-γ-dependent effector mechanisms.
AU  - Jankovic, D.
AU  - Wynn, T. A.
AU  - Kullberg, M. C.
AU  - Hieny, S.
AU  - Caspar, P.
AU  - James, S.
AU  - Cheever, A. W.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 162
IS  - 1
SP  - 345
EP  - 351
SN  - 0022-1767
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, Bldg. 4/126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990803611.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9008-11-1.  Subject Subsets: Helminthology
N2  - In order to investigate the respective contributions of the B lymphocyte- and IFN-γ-dependent effector arms in host resistance to Schistosoma mansoni, vaccine-induced immunity (using radiation-attenuated cercariae) was compared in B cell-deficient (µMT, KO) and IFN (interferon)-γ knockout (GKO) mice. Unexpectedly, after a single vaccination, B cell knockout (KO) mice displayed less protection (P&lt;0.005) against challenge infection, compared with control mice, although they developed a normal IFN-γ-dominated cytokine response giving them partial protection. This defect in resistance was equivalent to that displayed by GKO animals. Moreover, whereas 2 additional vaccinations significantly increased the level of immunity in wild-type mice (P&lt;0.02), the protection in B cell KO animals remained unchanged. In contrast, multiple vaccination resulted in increased, although still defective, resistance in GKO mice. Since FcR γ KO mice, which lack functional FcγRI, FcγRIII, and FcεRI, showed no defects in vaccine-induced resistance after immunization either one or 3 times, the B cell-dependent mechanism of protection involved does not appear to require FcR signalling. Together, these findings indicate that effective vaccination against schistosomes depends on the simultaneous induction of both humoral and cell-mediated immunity, a conclusion that may explain the limited success of most subunit vaccine protocols designed to preferentially induce either B cell- or IFN-γ-dependent protective mechanisms.
KW  - animal diseases
KW  - B lymphocytes
KW  - cell mediated immunity
KW  - experimental infections
KW  - helminths
KW  - human diseases
KW  - humoral immunity
KW  - immune response
KW  - immunity
KW  - immunization
KW  - interferon
KW  - laboratory animals
KW  - parasites
KW  - vaccination
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - B cells
KW  - cellular immunity
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs.
AU  - Chiaramonte, M. G.
AU  - Schopf, L. R.
AU  - Neben, T. Y.
AU  - Cheever, A. W.
AU  - Donaldson, D. D.
AU  - Wynn, T. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 162
IS  - 2
SP  - 920
EP  - 930
SN  - 0022-1767
AD  - Chiaramonte, M. G.: Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990803438.  Publication Type: Journal Article.  Language: English.  Number of References: 64 ref. Registry Number: 37341-29-0, 9008-11-1, 207137-56-2, 148157-34-0.  Subject Subsets: Helminthology
N2  - Schistosoma mansoni egg-induced pulmonary granuloma formation is a cell-mediated inflammatory response associated with dominant Th2-type cytokine expression, tissue eosinophilia and high levels of serum IgE. It was shown that in vivo blockade of the Th2 cytokine interleukin (IL)-13, using soluble IL-13R α2-Fc fusion protein, significantly reduced the size of pulmonary granulomas in unsensitized as well as egg-sensitized mice. Blocking IL-13 also significantly reduced total serum IgE levels. However, IL-13 blockade did not affect the evolving egg-induced Th2-type cytokine response. IL-4 and IL-5, as well as IL-13, responses were indistinguishable in control-Fc- and soluble IL-13R α2-Fc fusion protein-treated animals. The smaller granulomas were also phenotypically like the control Fc-treated mice, displaying a similar eosinophil content. Additional studies in IL-4-deficient mice demonstrated that IL-13 was produced, but at much lower levels than in wild-type mice, while IL-4 expression was completely independent of IL-13. While granuloma formation was partially reduced in IL-4-deficient mice, blocking IL-13 almost completely abrogated granuloma development and pulmonary eosinophilia, while it simultaneously increased interferon (IFN)-γ production. The results show that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs.
KW  - cell mediated immunity
KW  - cytokines
KW  - eosinophilia
KW  - experimental infections
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - IgE
KW  - immune response
KW  - inflammation
KW  - interferon
KW  - interleukin 13
KW  - interleukin 4
KW  - interleukin 5
KW  - interleukins
KW  - laboratory animals
KW  - lungs
KW  - parasites
KW  - recombinant proteins
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - cellular immunity
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - reagin
KW  - reaginic antibodies
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803438&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains.
AU  - Noben-Trauth, N.
AU  - Paul, W. E.
AU  - Sacks, D. L.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 162
IS  - 10
SP  - 6132
EP  - 6140
SN  - 0022-1767
AD  - Noben-Trauth, N.: Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, Twinbrook II, Room 125, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.
N1  - Accession Number: 19990805938.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref. Registry Number: 9008-11-1, 207137-56-2, 148157-34-0.  Subject Subsets: Protozoology
N2  - Using BALB/c mice deficient in interleukin (IL)-4 (IL-4-/-) or IL-4 receptor α-chain (IL-4Rα-/-), different disease outcomes to Leishmania major infection were observed depending on parasite substrain. Infection with L. major LV39 caused progressive nonhealing ulcers and uncontrolled parasite growth in both IL-4-/- and IL-4Rα-/- mice. In contrast, infection with L. major IR173 was partially controlled in IL-4-/- mice but efficiently controlled in IL-4Rα-/- mice. Both IL-4-/- and IL-4Rα-/- mice infected with either substrain displayed reduced Th2 responses. Interferon (IFN)-γ secretion was not up-regulated in the mutant mice, even in IL-4Rα-/- mice which were resistant to L. major IR173. Lack of increased IFN-γ production suggests that cytokine cross-regulation may not be operating in this model and that the effective ratios of Th1/Th2 cytokines become more indicative of disease outcome. The partial versus complete resistance to IR173 in IL-4-/- or IL-4Rα-/- mice implies that, in addition to IL-4, IL-13 may be involved in disease progression during L. major infection. The results with LV39 infection indicate that yet another unidentified factor is capable of causing susceptibility to L. major in the absence of IL-4 or IL-4 signalling.
KW  - cytokines
KW  - disease course
KW  - disease resistance
KW  - experimental infections
KW  - immune response
KW  - interferon
KW  - interleukin 13
KW  - interleukin 4
KW  - laboratory animals
KW  - parasites
KW  - receptors
KW  - strain differences
KW  - strains
KW  - susceptibility
KW  - T lymphocytes
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - disease progression
KW  - immunity reactions
KW  - immunological reactions
KW  - resistance to disease
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805938&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera.
AU  - Scala, G.
AU  - Chen XueNi
AU  - Liu WeiMin
AU  - Telles, J. N.
AU  - Cohen, O. J.
AU  - Vaccarezza, M.
AU  - Igarashi, T.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 162
IS  - 10
SP  - 6155
EP  - 6161
SN  - 0022-1767
AD  - Scala, G.: Laboratory of Immunoregulation/National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1576, USA.
N1  - Accession Number: 19992009587.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
N2  - Random peptide libraries were screened using sera from HIV-infected subjects to identify antigenic and immunogenic mimics of HIV-1 epitopes. After extensive counterscreening with HIV-negative sera, peptides specifically recognized by Abs from HIV-1-infected individuals were isolated. These peptides behaved as antigenic mimics of linear or conformational HIV-1 epitopes generated in vivo in infected subjects. Consistent with these findings, sera of simian HIV-infected monkeys also recognized the HIV-specific epitopes. The selected peptides were immunogenic in mice, where they elicited HIV-specific Abs that effectively neutralized HIV-1 isolates. These results demonstrated that pools of HIV-1 mimotopes can be selected from combinatorial peptide libraries by taking advantage of the HIV-specific Ab repertoire induced by the natural infection.
KW  - antigenic variation
KW  - antigens
KW  - envelope proteins
KW  - epitopes
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunogenetics
KW  - immunology
KW  - peptides
KW  - viral diseases
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - antigenic determinants
KW  - antigenic polymorphism
KW  - antigenicity
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - viral infections
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009587&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Induction of HIV-1 replication by allogeneic stimulation.
AU  - Moriuchi, H.
AU  - Moriuchi, M.
AU  - Fauci, A. S.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 162
IS  - 12
SP  - 7543
EP  - 7548
SN  - 0022-1767
AD  - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19992011596.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref.
N2  - Allogeneic stimulation presents an immunologic challenge during pregnancy, blood transfusions, and transplantations, and has been associated with reactivation of latently infected virus such as CMV. Since HIV-1 is transmitted vertically, sexually, or via contaminated blood, the effects of allostimulation on HIV-1 infection were tested. It was shown that (1) allostimulated lymphocytes are highly susceptible to acute infection with T cell-tropic or dual-tropic HIV-1; (2) allostimulation has dichotomous effects on replication of macrophage-tropic HIV-1 - it activates HIV expression in already infected cells but inhibits HIV entry by secreting HIV-suppressive CC chemokines; (3) allogeneic stimulation of latently infected, resting CD4+ T cells induced replication of HIV-1 in these cells. These observations suggest that allogeneic stimulation may play a role in the transmission, replication, and phenotypic transition of HIV-1.
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunology
KW  - lymphocytes
KW  - replication
KW  - stimulation
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011596&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile.
AU  - Jankovic, D.
AU  - Kullberg, M. C.
AU  - Noben-Trauth, N.
AU  - Caspar, P.
AU  - Ward, J. M.
AU  - Cheever, A. W.
AU  - Paul, W. E.
AU  - Sher, A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 163
IS  - 1
SP  - 337
EP  - 342
SN  - 0022-1767
AD  - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990806787.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 308067-58-5, 9008-11-1, 207137-56-2.  Subject Subsets: Helminthology
N2  - The function of the Th2 response in Schistosoma mansoni egg pathology was studied in interleukin (IL)-4Rα-deficient mice, which are nonresponsive to both IL-4 and IL-13. In striking contrast to IL-4 KO animals, infected IL-4Rα KO mice developed only minimal hepatic granulomas and fibrosis despite the presence of CD3+ T cells in the residual egg lesions. Liver lymphokine messenger RNA levels in these animals and IL-4 KO mice were equivalent. Infected IL-4Rα-deficient, IL-4-deficient and control mice developed similar egg antigen-specific IgG titres, arguing that CD4-dependent Th activity is intact in KO mice. As expected, IFN-γ secretion was strongly up-regulated in mesenteric lymph node cultures from both groups of deficient animals, a change reflected in increased serum IgG2a and IgG2b levels. Surprisingly, Th2 cytokine production in infected IL-4Rα KO mice was not abolished but was only reduced and resembled that previously documented in IL-4 KO animals. This residual Th2 response is likely to explain the ability of IL-4 KO mice to generate egg granulomas, which cannot be formed in IL-4Rα-deficient animals because of their lack of responsiveness to the same cytokine ligands. The results argue that tissue pathology in schistosomiasis requires, in addition to egg-specific CD4+ lymphocytes, a previously unrecognized IL-4Rα+ non-T cell effector population.
KW  - experimental infections
KW  - fibrosis
KW  - granuloma
KW  - helminth ova
KW  - helminths
KW  - IgG
KW  - immune response
KW  - immunopathology
KW  - interferon
KW  - interleukin 4
KW  - laboratory animals
KW  - liver
KW  - liver diseases
KW  - lymph nodes
KW  - mutants
KW  - parasites
KW  - T lymphocytes
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990806787&site=ehost-live&scope=site
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ER  - 

TY  - JOUR
T1  - Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni.
AU  - Hoffmann, K. F.
AU  - James, S. L.
AU  - Cheever, A. W.
AU  - Wynn, T. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 163
IS  - 2
SP  - 927
EP  - 938
SN  - 0022-1767
AD  - Hoffmann, K. F.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990807116.  Publication Type: Journal Article.  Language: English.  Number of References: 54 ref. Registry Number: 130068-27-8, 207137-56-2.  Subject Subsets: Helminthology
N2  - The radiation-attenuated Schistosoma mansoni cercariae vaccine was used in mice genetically engineered to exhibit highly polarized type 1 (interleukin [IL]-10/IL-4-deficient) or type 2 (IL-10/IL-12-deficient) cytokine and antibody phenotypes. Significant differences in immunity were apparent after a single vaccination with irradiated cercariae in double cytokine-deficient versus wild-type mice but these differences disappeared after 2 vaccinations. Vaccinated IL-10-deficient mice developed a mixed and elevated type 1- and type 2-associated immune response and developed anti-schistosome immunity at levels equal to or better than those in wild-type mice. This immunity in IL-10-deficient mice correlated with higher parasite-specific antibody titres, greater proliferative capacity of lymphocytes, increased frequency of interferon (IFN)-γ- and IL-4-secreting cells, elevated perivascular/peribronchial inflammatory responses in the lung, and greater in vitro schistosomulacidal capacity of parasite antigen-elicited cells. The results suggest that optimal vaccine-induced immunity against schistosomes is linked not to the development of a highly polarized response, but to the induction of both type 1- and type 2-associated immune responses.
KW  - antibodies
KW  - cercariae
KW  - cytokines
KW  - deficiency
KW  - helminths
KW  - immune response
KW  - immunity
KW  - immunization
KW  - interleukin 10
KW  - interleukin 12
KW  - interleukin 4
KW  - irradiated vaccines
KW  - laboratory animals
KW  - mutants
KW  - parasites
KW  - phenotypes
KW  - T lymphocytes
KW  - vaccines
KW  - mice
KW  - Schistosoma mansoni
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Schistosoma
KW  - Schistosomatidae
KW  - Digenea
KW  - Trematoda
KW  - Platyhelminthes
KW  - invertebrates
KW  - immune sensitization
KW  - immunity reactions
KW  - immunological reactions
KW  - parasitic worms
KW  - Strigeida
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807116&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major.
AU  - Dent, A. L.
AU  - Doherty, T. M.
AU  - Paul, W. E.
AU  - Sher, A.
AU  - Staudt, L. M.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 163
IS  - 4
SP  - 2098
EP  - 2103
SN  - 0022-1767
AD  - Dent, A. L.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990807962.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref. Registry Number: 207137-56-2, 148157-34-0.  Subject Subsets: Protozoology
N2  - The BCL-6 gene negatively regulates Th2 responses in mice. BCL-6-/- mice on a Leishmania major-resistant genetic background (C57BL/6 × 129 intercrossed mice) were highly susceptible to L. major infection; they resembled BALB/c mice in terms of lesion size, parasite load, and the production of Th2 cytokines. BCL-6-/-IL (interleukin)-4-/- double-mutant mice were also susceptible to L. major infection, and produced levels of the Th2 cytokine IL-13 ten-fold higher than those produced by IL-4-/- littermate controls. By contrast, BCL-6-/-STAT6-/- double-mutant mice were resistant to L. major infection, despite also producing elevated levels of IL-13. It is concluded that STAT6 is required for susceptibility to L. major infection, and suggested that IL-13 signalling through STAT6 may contribute to a non-healing, exacerbated infection.
KW  - animal diseases
KW  - cytokines
KW  - experimental infections
KW  - human diseases
KW  - immune response
KW  - immunity
KW  - immunopathology
KW  - interleukin 13
KW  - interleukin 4
KW  - laboratory animals
KW  - leishmaniasis
KW  - parasites
KW  - susceptibility
KW  - Leishmania major
KW  - mice
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - immunity reactions
KW  - immunological reactions
KW  - immunopathogenesis
KW  - leishmaniosis
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807962&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15Rβ receptor.
AU  - Azimi, N.
AU  - Jacobson, S.
AU  - Leist, T.
AU  - Waldmann, T. A.
JO  - Journal of Immunology (Baltimore)
JF  - Journal of Immunology (Baltimore)
Y1  - 1999///
VL  - 163
IS  - 7
SP  - 4064
EP  - 4072
SN  - 0022-1767
AD  - Azimi, N.: Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 20002006517.  Publication Type: Journal Article.  Language: English.  Number of References: 55 ref.
N2  - Human T lymphotropic virus type I (HTLV-I) is the causative agent of an inflammatory neurological disease termed HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). An ongoing lymphocyte activation exists in patients with HAM/TSP, which was demonstrated by the spontaneous proliferation of their PBMC ex vivo. It was shown that spontaneous proliferation present in HAM/TSP is due, in part, to an IL-2/IL-2R autocrine loop. However, addition of Abs against IL-2 or IL-2Rα only partially inhibited the spontaneous proliferation. Since IL-15 is a cytokine with similar functional characteristics to those of IL-2, it was reasoned that IL-15 might be an additional growth factor that contributes to the spontaneous proliferation observed in HAM/TSP. In this study, IL-15 mRNA expression was shown to be elevated in PBMC obtained from HAM/TSP patients when compared with those of the normal donors. Furthermore, it was shown that the addition of blocking Abs against IL-15 or its receptor inhibited the spontaneous proliferation of HAM/TSP PBMC. Addition of Abs directed toward both IL-15 and IL-2, or their receptors, inhibited the proliferation almost completely. These data suggest the existence of two autocrine loops involving IL-15/IL-15R and IL-2/IL-2R, both contributing to the spontaneous proliferation of HAM/TSP PBMC.
KW  - antibodies
KW  - cytokines
KW  - growth factors
KW  - human diseases
KW  - immunopathology
KW  - interleukins
KW  - lymphocyte transformation
KW  - myelopathy
KW  - pathogenesis
KW  - tropical spastic paraparesis
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - immunopathogenesis
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Human Immunology and Allergology (VV055) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006517&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Identification and characterization of novel variant major surface glycoprotein gene families in rat Pneumocystis carinii.
AU  - Huang, S. N.
AU  - Angus, C. W.
AU  - Turner, R. E.
AU  - Sorial, V.
AU  - Kovacs, J. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 179
IS  - 1
SP  - 192
EP  - 200
SN  - 0022-1899
AD  - Huang, S. N.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19991200803.  Publication Type: Journal Article.  Language: English.  Number of References: 45 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - Two novel variant major surface glycoprotein (vMSG) gene families in rat P. carinii that are closely related to but distinct from MSG were identified. These gene families encode proteins of ~90 kDa (v1MSG) and ~115 kDa (v2MSG). Compared with MSG, v1MSG is characterized by a deletion near the carboxyl terminus. The predicted v1MSG and v2MSG proteins are highly homologous to MSG at the carboxyl, but not the amino, terminus. Like MSG, they are cysteine-rich. Approx. 10% of the apparent molecular weight is due to N-linked glycosylation. Southern blotting studies demonstrated that, like MSG, v1MSG and v2MSG are the products of multicopy gene families. However, unlike MSG, each vMSG gene encodes a signal peptide, suggesting that the regulation of vMSG is different from that of MSG.
KW  - antigens
KW  - genes
KW  - major surface glycoproteins
KW  - molecular genetics
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - rats
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - antigenicity
KW  - biochemical genetics
KW  - fungus
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200803&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Eosinophil sequestration and activation are associated with the onset and severity of systemic adverse reactions following the treatment of onchocerciasis with ivermectin.
AU  - Cooper, P. J.
AU  - Awadzi, K.
AU  - Ottesen, E. A.
AU  - Remick, D.
AU  - Nutman, T. B.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 179
IS  - 3
SP  - 738
EP  - 742
SN  - 0022-1899
AD  - Cooper, P. J.: Laboratory of Parasitic Diseases, NIAID, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990804237.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Registry Number: 70288-86-7.  Subject Subsets: Helminthology; Tropical Diseases
N2  - To investigate the role of eosinophil activation and sequestration in the development and severity of adverse reactions after the treatment of Onchocerca volvulus infection, 40 O. volvulus-infected Ghanaians were randomized to receive a placebo, or ivermectin at a dose of 150, 400 or 600 mg/kg. Subjects were examined for typical physiologic and clinical events before and up to 48 h after treatment. Plasma samples were tested for interleukin (IL)-5 and eosinophil degranulation products (e.g., eosinophil-derived neurotoxin, EDN). After treatment, peripheral eosinophil counts declined in ivermectin-treated groups (P &lt;.001), whereas circulating levels of IL-5 (P &lt;.01) and EDN (P &lt;.05) increased. Cumulative levels of IL-5 and EDN correlated with reaction scores (P &lt;.01). High-dose ivermectin was associated with more severe reactions, more profound eosinopenia, and higher circulating levels of IL-5 and EDN, compared with the standard dose. These results suggest that eosinophil sequestration and activation/degranulation are associated with the initiation and severity of ivermectin-associated adverse reactions.
KW  - adverse effects
KW  - anthelmintics
KW  - blood plasma
KW  - drug therapy
KW  - eosinophils
KW  - helminths
KW  - human diseases
KW  - immunopathology
KW  - interleukin 5
KW  - ivermectin
KW  - neurotoxins
KW  - onchocerciasis
KW  - parasites
KW  - placebos
KW  - Ghana
KW  - man
KW  - Onchocerca volvulus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Onchocerca
KW  - Onchocercidae
KW  - Rhabditida
KW  - Chromadoria
KW  - Chromadorea
KW  - Nematoda
KW  - invertebrates
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - West Africa
KW  - Africa South of Sahara
KW  - adverse reactions
KW  - chemotherapy
KW  - eosinophil leukocytes
KW  - immunopathogenesis
KW  - nematodes
KW  - onchocercosis
KW  - parasitic worms
KW  - plasma (blood)
KW  - river blindness
KW  - Secernentea
KW  - Spirurida
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Physiology and Biochemistry (VV050) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection.
AU  - Davey, R. T., Jr.
AU  - Chaitt, D. G.
AU  - Albert, J. M.
AU  - Piscitelli, S. C.
AU  - Kovacs, J. A.
AU  - Walker, R. E.
AU  - Falloon, J.
AU  - Polis, M. A.
AU  - Metcalf, J. A.
AU  - Masur, H.
AU  - Dewar, R.
AU  - Baseler, M.
AU  - Fyfe, G.
AU  - Giedlin, M. A.
AU  - Lane, H. C.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 179
IS  - 4
SP  - 849
EP  - 858
SN  - 0022-1899
AD  - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Room 11C103, Bethesda, MD 20892-1880, USA.
N1  - Accession Number: 19992006359.  Publication Type: Journal Article.  Language: English.  Number of References: 17 ref. Registry Number: 102524-44-7, 85898-30-2.  Subject Subsets: Public Health
N2  - A total of 49 outpatients infected with human immunodeficiency virus with baseline CD4 cell counts ≥500/mm³, who were on stable antiretroviral therapy, were randomized to receive 5-day cycles of either low-dose (1.5 million IU [MIU] twice a day) or high-dose (7.5 MIU twice a day) subcutaneous (sc) interleukin (IL)-2 every 4 or 8 weeks. High-dose recipients experienced mean CD4 cell and percent slopes of +116.1 cells/month and +2.7%/month, respectively, whereas low-dose recipients displayed mean slopes of +26.7 and +1.3% in the same parameters. At month 6, high-dose recipients achieved a 94.8% increase in mean CD4 cells over baseline compared with a 19.0% increase in low-dose recipients. Although high-dose recipients encountered more constitutional side effects, these were generally not dose-limiting. It is concluded that high-dose scIL-2 therapy in outpatients with early HIV-1 infection was well tolerated and induced dramatic, sustained rises in CD4 cells.
KW  - CD4 antigens
KW  - cytokines
KW  - dosage
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunotherapy
KW  - interleukin 2
KW  - T lymphocytes
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - CD4
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - T cells
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006359&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus.
AU  - De Tan
AU  - Matsumoto, A.
AU  - Conry-Cantilena, C.
AU  - Melpolder, J. C.
AU  - Shih, J. W. K.
AU  - Leuther, M.
AU  - Hess, G.
AU  - Gibble, J. W.
AU  - Ness, P. M.
AU  - Alter, H. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 179
IS  - 5
SP  - 1055
EP  - 1061
SN  - 0022-1899
AD  - De Tan: Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992008728.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Registry Number: 63231-63-0.  Subject Subsets: Public Health
N2  - Serological, biochemical, and molecular analyses were used to study hepatitis G virus (HGV), antibody to the HGV envelope protein (anti-E2), risk factors, clinical significance, and the impact of HGV on coexistent hepatitis C virus (HCV). Among 329 donors in the USA with confirmed HCV infection, 12% were HGV RNA-positive and 44% were anti-E2-positive (total exposure, 56%). HGV RNA and anti-E2 were mutually exclusive except in 9 donors (1.5%); 8 of 9 subsequently lost HGV RNA but anti-E2 persisted. HGV had little impact on alanine aminotransferase, aspartate aminotransferase, or γ-glutamyl transpeptidase in donors with HGV infection alone or those co-infected with HCV. A multivariate analysis showed that injecting drug abuse was the leading risk factor for HGV transmission, followed by blood transfusion, snorting cocaine, imprisonment, and a history of sexually transmitted diseases. In summary, HGV and HCV infections were frequently associated and shared common parenteral risk factors; HGV did not appear to cause hepatitis or to worsen the course of coexistent hepatitis C.
KW  - blood donors
KW  - concurrent infections
KW  - human diseases
KW  - risk factors
KW  - RNA
KW  - USA
KW  - GB virus C
KW  - hepatitis C virus
KW  - hepatitis G virus
KW  - man
KW  - Flaviviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - Hepacivirus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - GB virus
KW  - ribonucleic acid
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008728&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Association of major histocompatibility complex determinants with the development of symptomatic and asymptomatic genital herpes simplex virus type 2 infections.
AU  - Lekstrom-Himes, J. A.
AU  - Hohman, P.
AU  - Warren, T.
AU  - Wald, A.
AU  - Nam JunMo
AU  - Simonis, T.
AU  - Corey, L.
AU  - Straus, S. E.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 179
IS  - 5
SP  - 1077
EP  - 1085
SN  - 0022-1899
AD  - Lekstrom-Himes, J. A.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, UK.
N1  - Accession Number: 19992008731.  Publication Type: Journal Article.  Language: English.  Number of References: 67 ref. Subject Subsets: Public Health
N2  - The clinical spectrum of herpes simplex virus (HSV) infections, ranging from asymptomatic to frequently distressing outbreaks, suggests that there may be immunological determinants of disease severity that are associated with human leukocyte antigen (HLA) expression. A controlled, prospective study identified several major histocompatibility complex (MHC) class I and II antigens whose frequencies are associated with HSV-2 infection or with frequent symptomatic genital recurrences. Previous studies were hampered by the inability to serologically identify patients with asymptomatic HSV-2 infection. Clinical evaluation and Western blot assay were used to identify 3 subject cohorts in the USA: 1 with no prior HSV infections, 1 with HSV-2 antibodies but no recognized symptoms, and 1 with HSV-2 antibodies and frequent genital recurrences. Statistical comparisons of HLA frequencies among these cohorts showed associations of HLA-B27 and -Cw2 with symptomatic disease. Also, HLA-Cw4 was significantly associated with HSV-2 infection. These associations indicate that immunological factors linked to the MHC influence the risk of HSV-2 infection and disease expression.
KW  - disease course
KW  - disease resistance
KW  - herpes simplex genitalis
KW  - human diseases
KW  - human leukocyte antigens
KW  - immunological factors
KW  - major histocompatibility complex
KW  - pathogenesis
KW  - symptoms
KW  - USA
KW  - Human herpesvirus 2
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Simplexvirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - disease progression
KW  - herpes simplex virus 2
KW  - histocompatibility complex
KW  - resistance to disease
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008731&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - HIV infection, mucosal immunity and pathogenesis.
A2  - Kresina, T. F.
A2  - Mathieson, B.
T2  - Journal of Infectious Diseases
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 179
IS  - Suppl. 3
SP  - S391
EP  - S498
SN  - 0022-1899
AD  - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992009344.  Publication Type: Conference proceedings.  Language: English. 
KW  - HIV infections
KW  - immunity
KW  - mucosa
KW  - pathogenesis
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mucous membrane
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009344&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Correlation of quantitative bone marrow and blood cultures in AIDS patients with disseminated Mycobacterium avium complex infection.
AU  - Hafner, R.
AU  - Inderlied, C. B.
AU  - Peterson, D. M.
AU  - Wright, D. J.
AU  - Standiford, H. C.
AU  - Drusano, G.
AU  - Muth, K.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 2
SP  - 438
EP  - 447
SN  - 0022-1899
AD  - Hafner, R.: Division of AIDS, National Institute of Allergy and Infectious Diseases, 6700-B Rockledge Dr. MSC 7624, Bethesda, MD 20892-7624, USA.
N1  - Accession Number: 20002007148.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref.
N2  - The relationship between Mycobacterium avium complex (MAC) infection of blood and bone marrow was studied in human immunodeficiency virus-infected patients before and during treatment. Quantitative cultures were obtained at baseline from 17 persons with newly detected MAC bacteraemia. Serial blood cultures were obtained, and a second bone marrow sample was obtained at 4 or 8 weeks. At baseline, the median MAC load in bone marrow core samples was 3 log10 higher than in blood. Bone marrow MAC loads ranged widely (866-847 315 cfu/g), and no significant correlation was found between MAC load in blood and that in bone marrow core samples. MAC loads in bilateral bone marrow biopsy samples from 7 subjects were highly correlated. MAC loads declined in blood and bone marrow at similar rates during therapy, but blood was sterilized before bone marrow. Length of survival was inversely associated with initial bone marrow core MAC load but not with blood MAC load. Initiation of treatment when tissue MAC load is low may increase the likelihood of favourable clinical outcome.
KW  - acquired immune deficiency syndrome
KW  - bacteraemia
KW  - bone marrow
KW  - clinical aspects
KW  - disseminated infections
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium avium
KW  - Mycobacterium avium complex
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - AIDS
KW  - bacteremia
KW  - bacterium
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007148&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani.
AU  - Lira, R.
AU  - Shyam Sundar
AU  - Makharia, A.
AU  - Kenney, R.
AU  - Gam, A.
AU  - Saraiva, E.
AU  - Sacks, D.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 2
SP  - 564
EP  - 567
SN  - 0022-1899
AD  - Lira, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19990807872.  Publication Type: Journal Article.  Language: English.  Number of References: 15 ref. Registry Number: 7440-36-0, 12550-17-3.  Subject Subsets: Protozoology
N2  - The possibility that the high frequency of treatment failures in Indian kala azar might be due to infection with antimony-resistant strains of Leishmania donovani was experimentally addressed. L. donovani isolates were obtained from splenic aspiration smears of 24 patients in Bihar, India, who either did not respond (15) or did respond (9) to one or more full courses of treatment with sodium antimony gluconate (SAG). A strong correlation (P&lt;0.001) between clinical response and SAG sensitivity in vitro was observed only when strains were assayed as intracellular amastigotes: responsive isolates ED50 = 2.4 ± 2.6 µg SAG/ml, ED90 = 6.4 ± 7.8 µg SAG/ml; unresponsive isolates ED50 = 7.4 ± 3.7 µg SAG/ml, ED90 = 29.1 ± 11.1 SAG/ml. No correlation with clinical response was found by use of extracellular promastigotes (ED50 = 48 ± 22 versus 52 ± 29 µg SAG/ml). The emergence of antimony-resistant L. donovani strains appears to be a cause of treatment failure in India.
KW  - amastigotes
KW  - antimony
KW  - antimony sodium gluconate
KW  - antiprotozoal agents
KW  - drug resistance
KW  - human diseases
KW  - in vitro
KW  - kala azar
KW  - leishmaniasis
KW  - parasites
KW  - promastigotes
KW  - spleen
KW  - strains
KW  - treatment failure
KW  - visceral leishmaniasis
KW  - Bihar
KW  - India
KW  - Leishmania donovani
KW  - man
KW  - protozoa
KW  - Leishmania
KW  - Trypanosomatidae
KW  - Kinetoplastida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - India
KW  - Commonwealth of Nations
KW  - Developing Countries
KW  - South Asia
KW  - Asia
KW  - antimonials
KW  - leishmaniosis
KW  - sodium antimony gluconate
KW  - Pesticide and Drug Resistance (HH410) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807872&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preliminary evaluation of human immunodeficiency virus type 1 (HIV-1) immunogen in children with HIV-1 infection.
AU  - Sei, S.
AU  - Sandelli, S. L.
AU  - Theofan, G.
AU  - Ratto-Kim, S.
AU  - Kumagai, M.
AU  - Loomis-Price, L. D.
AU  - Cox, J. H.
AU  - Jarosinski, P.
AU  - Walsek, C. M.
AU  - Brouwers, P.
AU  - Venzon, D. J.
AU  - Xu Jing
AU  - Pizzo, P. A.
AU  - Moss, R. B.
AU  - Robb, M. L.
AU  - Wood, L. V.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 3
SP  - 626
EP  - 640
SN  - 0022-1899
AD  - Sei, S.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19992012711.  Publication Type: Journal Article.  Language: English.  Number of References: 75 ref. Subject Subsets: Public Health
N2  - The safety and preliminary activity of human immunodeficiency virus type 1 (HIV-1) immunogen were evaluated [date not given] in 10 HIV-1-infected children with disease stage N1,2 or A1,2 in the USA . Multiple inoculations of 2.5 or 10 units (U) of HIV-1 immunogen were safe and well tolerated without an acceleration of disease progression. When antiretroviral agents were coadministered, the 10 U dose appeared to be associated with more sustained reduction in plasma HIV-1 RNA than the 2.5 U dose (median log10 HIV-1 RNA at month 18, 3.07 vs. 4.01 copies/ml in 10 U (n=4) vs. 2.5 U (n=3), respectively; P=0.034). Levels of regulated-on-activation, normal T cell-expressed and -secreted chemokine produced from HIV-1 immunogen-stimulated lymphocytes in vitro were increased in the children who had HIV-1 immunogen-specific antibody responses (P&lt;0.02) and appeared to be inversely correlated with levels of plasma HIV-1 RNA (P&lt;0.01). It is suggested that these preliminary data warrant larger studies to determine the effectiveness of adjunctive therapy with HIV-1 immunogen in children with HIV-1 infection.
KW  - antigens
KW  - chemokines
KW  - children
KW  - clinical aspects
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - immune response
KW  - immunotherapy
KW  - lymphocytes
KW  - safety
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - antigenicity
KW  - chemotherapy
KW  - clinical picture
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - immunity reactions
KW  - immunogenicity
KW  - immunogens
KW  - immunological reactions
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012711&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HTLV-I/II seroindeterminate western blot reactivity in a cohort of patients with neurological disease.
AU  - Soldan, S. S.
AU  - Graf, M. D.
AU  - Waziri, A.
AU  - Flerlage, A. N.
AU  - Robinson, S. M.
AU  - Kawanishi, T.
AU  - Leist, T. P.
AU  - Lehky, T. J.
AU  - Levin, M. C.
AU  - Jacobson, S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 3
SP  - 685
EP  - 694
SN  - 0022-1899
AD  - Soldan, S. S.: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 5B-16, Bethesda, MD 10892, USA.
N1  - Accession Number: 19992012716.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Public Health
N2  - Eight patients with neurological disease and an human T-cell lymphotropic virus type I/II (HTLV-I/II) seroindeterminate Western blot pattern were identified in Japan and the USA, none of whom demonstrated increased spontaneous proliferation and HTLV-I-specific cytotoxic T lymphocyte activity. However, HTLV-I tax sequence was amplified from the peripheral blood lymphocytes of 4 of them. It is suggested that patients with chronic progressive neurological disease and HTLV-I/II Western blot seroindeterminate reactivity may harbour either defective HTLV-I, novel retrovirus with partial homology to HTLV-I, or HTLV-I in low copy number.
KW  - clinical aspects
KW  - diagnosis
KW  - HTLV-I infections
KW  - human diseases
KW  - nervous system diseases
KW  - screening
KW  - T lymphocytes
KW  - tropical spastic paraparesis
KW  - Japan
KW  - USA
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type I
KW  - human T-cell lymphotropic virus type II
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - East Asia
KW  - Asia
KW  - OECD Countries
KW  - North America
KW  - America
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - clinical picture
KW  - HTLV-BLV group
KW  - neuropathy
KW  - screening tests
KW  - T cells
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Risk factors for human T cell lymphotropic virus type II infection among the Guaymi Indians of Panama.
AU  - Maloney, E. M.
AU  - Armien, B.
AU  - Gracia, F.
AU  - Castillo, L.
AU  - Kruger, H.
AU  - Levin, A.
AU  - Levine, P. H.
AU  - Kaplan, J. E.
AU  - Blattner, W. A.
AU  - Giusti, R. M.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 3
SP  - 876
EP  - 879
SN  - 0022-1899
AD  - Maloney, E. M.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza N., Room 434, 6130 Executive Blvd., MSC 7399, Bethesda, MD 20892-7399, USA.
N1  - Accession Number: 19992012730.  Publication Type: Journal Article.  Language: English.  Number of References: 8 ref. Subject Subsets: Tropical Diseases
N2  - A case-control study was conducted among the Guaymi Indians of Panama to examine risk factors for human T cell lymphotropic virus type II (HTLV-II) infection. 198 of 334 seropositive Guaymi ≥12 years of age, residing on 10 banana plantations in and around Changuinola, Bocas del Toro Province, and 460 matched seronegative controls, were enrolled between August 1994 and June 1996. In females, HTLV-II seropositivity was associated with early sexual intercourse (≤13 vs.&gt;15 years; odds ratio (OR), 2.50; 95% confidence interval (CI), 1.11-6.14) and number of lifetime sex partners. One partner increased risk of seropositivity by 30% (OR, 1.30; CI, 1.05-1.64), and risk increased with number of partners. Similar risk was associated with number of long-term sexual relationships. Among males, intercourse with prostitutes was associated with HTLV-II seropositivity (OR, 1.68; CI, 1.04-2.72). These data support a role for sexual transmission in HTLV-II infection. It is suggested that association of seropositivity with primary residence in a traditional village (OR, 3.75; CI, 1.02-15.38) and lack of formal education (0 vs. &gt;6 years (OR, 3.89; CI, 1.67-9.82)) observed in males may reflect differences in sexual practices associated with acculturation.
KW  - disease transmission
KW  - education
KW  - ethnic groups
KW  - human diseases
KW  - males
KW  - prostitutes
KW  - prostitution
KW  - risk factors
KW  - sex differences
KW  - sexual behaviour
KW  - sexual intercourse
KW  - sexual partners
KW  - sexual transmission
KW  - villages
KW  - Panama
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus type II
KW  - man
KW  - Human T-cell lymphotropic virus
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Central America
KW  - America
KW  - Developing Countries
KW  - Latin America
KW  - Threshold Countries
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - HTLV-BLV group
KW  - sexual behavior
KW  - sexual practices
KW  - sexuality
KW  - venereal transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Social Psychology and Culture (UU490) (Discontinued March 2000)
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TY  - JOUR
T1  - Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma.
AU  - O'Brien, T. R.
AU  - Kedes, D.
AU  - Ganem, D.
AU  - Macrae, D. R.
AU  - Rosenberg, P. S.
AU  - Molden, J.
AU  - Goedert, J. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 4
SP  - 1010
EP  - 1017
SN  - 0022-1899
AD  - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 8016, Rockville, MD 20852, USA.
N1  - Accession Number: 20002008396.  Publication Type: Journal Article.  Language: English.  Number of References: 36 ref.
N2  - Human herpesvirus 8 (HHV-8) seroprevalence and seroincidence was examined among 245 homosexual men from New York City (NYC) and Washington, DC (DC), USA, who have been followed since 1982. An immunofluorescence assay measured antibodies to a latent HHV-8 nuclear antigen. Seroprevalence was 20.4% in 1982; seroincidence was ~15%/year during 1982-1983 but fell sharply thereafter. NYC men had a higher seroprevalence (odds ratio, 3.43; P&lt;0.001) and seroincidence (rate ratio, 2.13; P=0.01) than DC men. Risk of Kaposi's sarcoma (KS) was increased in seropositive men (adjusted relative hazard, 3.58; P=0.02). Among men who were seropositive for both human immunodeficiency virus type 1 and HHV-8, the 10-year cumulative risk of KS was 39%; time from coinfection to KS diagnosis ranged from 15 to 154 months (median, 63.5 months). This study shows an epidemic of HHV-8 among US homosexual men in the early 1980s that was associated with a high risk of developing KS.
KW  - antibodies
KW  - concurrent infections
KW  - epidemics
KW  - epidemiology
KW  - HIV-1 infections
KW  - homosexuality
KW  - human diseases
KW  - incidence
KW  - Kaposi's sarcoma
KW  - men
KW  - risk factors
KW  - seroprevalence
KW  - District of Columbia
KW  - New York
KW  - USA
KW  - Herpesviridae
KW  - human herpesvirus 8
KW  - Human immunodeficiency virus 1
KW  - man
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Herpesviridae
KW  - Rhadinovirus
KW  - Gammaherpesvirinae
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - Middle Atlantic States of USA
KW  - Northeastern States of USA
KW  - homosexuals
KW  - human immunodeficiency virus type 1
KW  - United States of America
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997.
AU  - Engels, E. A.
AU  - Rosenberg, P. S.
AU  - Biggar, R. J.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 6
SP  - 1784
EP  - 1789
SN  - 0022-1899
AD  - Engels, E. A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., MSC 7248, Rockville, MD 20822, USA.
N1  - Accession Number: 20002009218.  Publication Type: Journal Article.  Corporate Author: USA, District of Columbia Gay Cohort; Multicenter Hemophilia Cohort Study Language: English.  Number of References: 29 ref. Subject Subsets: Public Health
N2  - Risk factors for zoster and trends in incidence in human immunodeficiency virus (HIV)-infected haemophiliacs and homosexual men from the USA and Europe (n=1218) were examined. 174 zoster cases were identified between 1984 and 1997 (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk (RR), 4.30; 95% confidence interval (CI), 3.11-5.95). Among haemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts were &gt;200 cells/mm³, but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or aciclovir use.
KW  - adolescents
KW  - children
KW  - haemophilia
KW  - herpes zoster
KW  - HIV infections
KW  - homosexuality
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - incidence
KW  - leukocyte count
KW  - men
KW  - opportunistic infections
KW  - risk factors
KW  - shingles
KW  - Europe
KW  - USA
KW  - Human herpesvirus 3
KW  - man
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - Varicellovirus
KW  - Alphaherpesvirinae
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cell count
KW  - hemophilia
KW  - homosexuals
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - teenagers
KW  - United States of America
KW  - varicella-zoster virus
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Immunology and Allergology (VV055) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Virus levels in untreated African infants infected with human immunodeficiency virus type 1.
AU  - Biggar, R. J.
AU  - Janes, M.
AU  - Pilon, R.
AU  - Miotti, P.
AU  - Taha, T. E. T.
AU  - Broadhead, R.
AU  - Mtimivalye, L.
AU  - Kumwenda, N.
AU  - Cassol, S.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 6
SP  - 1838
EP  - 1843
SN  - 0022-1899
AD  - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 20002009224.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Tropical Diseases
N2  - Human immunodeficiency virus levels were assessed during 1994-97 in untreated infants in Malawi by analysis of dried blood spots tested by nucleic acid silica-bound amplification. Of 24 umbilical cord blood (CB)-positive samples, 83% had &gt;10 000 copies/ml. The median virus level was 78 000 copies/ml. First positive sample median levels were 355 000 copies/ml among 52 perinatally infected infants and 130 000 copies/ml among 43 infants infected by breast-feeding. Virus levels were stable and initial levels predicted levels one year after infection (P=0.005), at which time levels did not significantly differ among in utero, perinatally, or postnatally infected infants. Neither age at infection nor route of infection significantly influenced HIV levels measured one year after infection. Most (87%) CB-positive infants were infected before labour onset, since virus levels greatly exceeded those expected in their mothers.
KW  - HIV infections
KW  - HIV-1 infections
KW  - human diseases
KW  - infants
KW  - maternal transmission
KW  - mothers
KW  - viral load
KW  - women
KW  - Malawi
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - ACP Countries
KW  - Anglophone Africa
KW  - Africa
KW  - Commonwealth of Nations
KW  - East Africa
KW  - Africa South of Sahara
KW  - Least Developed Countries
KW  - Developing Countries
KW  - SADC Countries
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - Nyasaland
KW  - Human Reproduction and Development (VV060) 
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.
AU  - Ma LiAng
AU  - Borio, L.
AU  - Masur, H.
AU  - Kovacs, J. A.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999///
VL  - 180
IS  - 6
SP  - 1969
EP  - 1978
SN  - 0022-1899
AD  - Ma LiAng: Critical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892-1662, USA.
N1  - Accession Number: 20001202187.  Publication Type: Journal Article.  Language: English.  Number of References: 39 ref. Registry Number: 80-08-0, 9002-03-3, 723-46-6, 738-70-5.  Subject Subsets: Medical & Veterinary Mycology
N2  - To explore whether P. carinii is developing resistance to trimethoprim (TMP), the human P. carinii dihydrofolate reductase (DHFR) gene was cloned. DHFR and dihydropteroate synthase (DHPS) genes in 37 P. carinii isolates, obtained from 35 patients in Maryland, USA, between 1985 and 1998, were sequenced. The relationship between TMP-sulfamethoxazole or dapsone use and gene mutations was analysed. The DHFR gene sequences were identical in all isolates except one with a synonymous substitution. In contrast, the DHPS gene sequences showed mutations in 16 of the 37 isolates; prior sulfa/sulfone prophylaxis was associated with the presence of these mutations (P&lt;0.001). It is concluded that, in addition to suggesting that there is less selective pressure on DHFR than on DHPS, this study reinforces the hypothesis that mutations in the DHPS genes are involved in the development of sulfa-resistance in P. carinii. Nucleotide sequences reported were submitted to the GenBank databases under Accession Numbers AF090368 and AF139132.
KW  - dapsone
KW  - dihydrofolate reductase
KW  - drug resistance
KW  - genes
KW  - human diseases
KW  - mutations
KW  - nucleotide sequences
KW  - sulfamethoxazole
KW  - trimethoprim
KW  - Maryland
KW  - USA
KW  - man
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystis carinii
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Pneumocystis
KW  - Pneumocystidaceae
KW  - Pneumocystidales
KW  - Pneumocystidomycetes
KW  - Taphrinomycotina
KW  - Ascomycota
KW  - fungi
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - dihydropteroate synthase
KW  - DNA sequences
KW  - fungus
KW  - sulphamethoxazole
KW  - tetrahydrofolate dehydrogenase
KW  - United States of America
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Pesticide and Drug Resistance (HH410) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Isolation, characterization, and localization of a capsule-associated gene, CAP10, of Cryptococcus neoformans.
AU  - Chang, Y. C.
AU  - Kwon-Chung, K. J.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1999///
VL  - 181
IS  - 18
SP  - 5636
EP  - 5643
SN  - 0021-9193
AD  - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20001203767.  Publication Type: Journal Article.  Language: English.  Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology
N2  - The isolation and characterization of a novel gene, CAP10, which is required for C. neoformans capsule formation, is described. Complementation of the acapsular cap10 mutant produced an encapsulated strain and the deletion of CAP10 from a wild strain resulted in an acapsular phenotype. The molecular mass of the haemagglutinin epitope-tagged Cap10p is about 73 kDa, which is similar to the size predicted from sequence analysis. When CAP10 was fused with a hybrid green fluorescent protein construct, the fluorescence signals appeared as patches in the cytoplasm. Using a reporter gene construct, it was found that CAP10 was expressed at high levels in late-stationary-phase cells. In addition, the expression levels of CAP10 were modulated by the transcriptional factor STE12α. Deletion of STE12α downregulated the expression levels of CAP10 while overexpression of STE12α upregulated the expression levels of CAP10. Animal model studies in mice indicated that deletion of the CAP10 gene resulted in the loss of virulence, and complementation of the acapsular phenotype of cap10 restored virulence. Thus, CAP10 is required for capsule formation and virulence.
KW  - cryptococcosis
KW  - experimental infections
KW  - genes
KW  - laboratory animals
KW  - molecular genetics
KW  - morphology
KW  - pathogenicity
KW  - phenotypes
KW  - virulence
KW  - Cryptococcus neoformans
KW  - mice
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - fungi
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - biochemical genetics
KW  - capsule
KW  - european blastomycosis
KW  - fungus
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW  - Animal Models of Human Diseases (VV400) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus.
AU  - Tsai HueiFung
AU  - Wheeler, M. H.
AU  - Chang, Y. C.
AU  - Kwon-Chung, K. J.
JO  - Journal of Bacteriology
JF  - Journal of Bacteriology
Y1  - 1999///
VL  - 181
IS  - 20
SP  - 6469
EP  - 6477
SN  - 0021-9193
AD  - Tsai HueiFung: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, 10 Center Dr., MSC 1882, Bethesda, MD 20892-1882, USA.
N1  - Accession Number: 20001202907.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref. Registry Number: 9007-49-2.  Subject Subsets: Medical & Veterinary Mycology
N2  - Six genes, forming a gene cluster spanning 19 kb, were identified as involved in conidial pigment biosynthesis in A. fumigatus. Northern blot analyses showed the 6 genes to be developmentally regulated and expressed during conidiation. The gene products of alb1 (for "albino 1"), arp1 (for "aspergillus reddish-pink 1") and arp2 have high similarity to polyketide synthases, scytalone dehydratases and hydroxynaphthalene reductases, respectively, found in the dihydroxynaphthalene (DHN)-melanin pathway of brown and black fungi. The abr1 gene (for "aspergillus brown 1") encodes a putative protein possessing 2 signatures of multicopper oxidases. The abr2 gene product has homology to the laccase encoded by the yA gene of A. nidulans. The function of ayg1 (for "aspergillus yellowish-green 1") remains unknown. Involvement of the 6 genes in conidial pigmentation was confirmed by the altered conidial colour phenotypes that resulted from disruption of each gene in A. fumigatus. The presence of a DHN-melanin pathway in A. fumigatus was supported by the accumulation of scytalone and flaviolin in the arp1 deletant, whereas only flaviolin was accumulated in the arp2 deletants. Scytalone and flaviolin are well-known signature metabolites of the DHN-melanin pathway. Based on DNA sequence similarity, gene disruption results, and biochemical analyses, it is concluded that the 19-kb DNA fragment contains a 6-gene cluster which is required for conidial pigment biosynthesis in A. fumigatus. However, the presence of abr1, abr2, and ayg1 in addition to alb1, arp1, and arp2 suggests that conidial pigment biosynthesis in A. fumigatus is more complex than the known DHN-melanin pathway.
KW  - biosynthesis
KW  - DNA
KW  - genes
KW  - genetics
KW  - metabolites
KW  - nucleotide sequences
KW  - pathogenicity
KW  - phenotypes
KW  - physiology
KW  - pigmentation
KW  - pigments
KW  - Aspergillus
KW  - Aspergillus fumigatus
KW  - Emericella nidulans
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Aspergillus
KW  - Emericella
KW  - Aspergillus nidulans
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - fungus
KW  - Hyphomycetes
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW  - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-γ- and tumor necrosis factor (TNF)-α-dependent host resistance to the intracellular pathogen, Toxoplasma gondii.
AU  - Yap, G. S.
AU  - Sher, A.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1999///
VL  - 189
IS  - 7
SP  - 1083
EP  - 1091
SN  - 0022-1007
AD  - Yap, G. S.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990804394.  Publication Type: Journal Article.  Language: English.  Number of References: 50 ref. Registry Number: 9008-11-1, 10102-43-9, 308079-78-9.  Subject Subsets: Protozoology
N2  - Pathogens within non-haemopoietic cells may be killed by metabolites secreted by activated macrophages or, alternatively, directly controlled by cytokine-induced microbicidal mechanisms triggered within infected non-phagocytic cells. To distinguish between these 2 basic mechanisms of cell mediated immunity, reciprocal bone marrow chimaeras were constructed between wild-type and interferon (IFN)-γ receptor-deficient mice and their survival was assessed following infection with Toxoplasma gondii, which invades both haemopoietic and non-haemopoietic cell lineages. Resistance to acute and persistent infection was displayed only by animals in which INF-γ receptors were expressed in both cellular compartments. Parallel chimaera experiments performed with tumour necrosis factor (TNF) receptor-deficient mice also indicated a co-dependence on haemopoietic and non-haemopoietic lineages for optimal control of the parasite. In contrast, in mice chimaeric for inducible nitric oxide synthase (iNOS), an enzyme associated with IFN-γ-induced macrophage microbicidal activity, expression by cells of haemopoietic origin was sufficient for host resistance. The results suggest that, in concert with bone marrow-derived effectors, non-haemopoietic cells can directly mediate, in the absence of endogenous iNOS, IFN-γ- and TNF-α-dependent host resistance to intracellular infection.
KW  - bone marrow
KW  - cell mediated immunity
KW  - cells
KW  - cytokines
KW  - deficiency
KW  - disease resistance
KW  - enzymes
KW  - experimental infections
KW  - haematopoiesis
KW  - immune response
KW  - interferon
KW  - laboratory animals
KW  - macrophages
KW  - metabolites
KW  - mutants
KW  - nitric oxide
KW  - parasites
KW  - receptors
KW  - tumour necrosis factor
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - blood formation
KW  - cachectin
KW  - cachexin
KW  - cellular immunity
KW  - haemopoiesis
KW  - hematopoiesis
KW  - immunity reactions
KW  - immunological reactions
KW  - nitric oxide synthase
KW  - resistance to disease
KW  - tumor necrosis factor
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction.
AU  - Tonnetti, L.
AU  - Verí, M. C.
AU  - Bonvini, E.
AU  - D'Adamio, L.
JO  - Journal of Experimental Medicine
JF  - Journal of Experimental Medicine
Y1  - 1999///
VL  - 189
IS  - 10
SP  - 1581
EP  - 1589
SN  - 0022-1007
AD  - Tonnetti, L.: T-Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991201952.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Registry Number: 9026-43-1. 
N2  - Studying apoptosis induced by T cell receptor (TCR) cross-linking in the T cell hybridoma, 3DO, both neutral sphingomyelinase activation and production of ceramide was found upon receptor engagement. Pharmacological inhibition of ceramide production by fumonisin B1 impaired TCR-induced interleukin (IL)-2 production and programmed cell death. Addition of either exogenous ceramide or bacterial sphingomyelinase reconstituted both responses. Moreover, specific inactivation of neutral sphingomyelinase by antisense RNA inhibited IL-2 production and mitogen-activated protein kinase activation after TCR triggering. It is suggested that ceramide production by activation of neutral sphingomyelinase is an essential component of the TCR signalling machinery.
KW  - apoptosis
KW  - fumonisins
KW  - protein kinase
KW  - T lymphocytes
KW  - toxicity
KW  - ceramide
KW  - T cells
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201952&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Plasmodium gallinaceum ookinetes adhere specifically to the midgut epithelium of Aedes aegypti by interaction with a carbohydrate ligand.
AU  - Zieler, H.
AU  - Nawrocki, J. P.
AU  - Shahabuddin, M.
JO  - Journal of Experimental Biology
JF  - Journal of Experimental Biology
Y1  - 1999///
VL  - 202
IS  - 5
SP  - 485
EP  - 495
SN  - 0022-0949
AD  - Zieler, H.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990503696.  Publication Type: Journal Article.  Language: English.  Number of References: 76 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2  - During the course of its development in Culicidae and transmission to a new vertebrate host, Plasmodium must interact with the mosquito midgut and invade the gut epithelium. To investigate how the parasite recognizes the midgut before invasion, an in vitro adhesion assay based on combining fluorescently labelled ookinetes with isolated midgut epithelia from blood-fed mosquitoes was developed. Using this assay, it was found that P. gallinaceum ookinetes readily adhered to midguts of A. aegypti, mimicking the natural recognition of the epithelium by the parasite. This interaction is specific: the ookinetes preferentially adhered to the lumen (microvillar) side of the gut epithelium and did not bind to other mosquito tissues. Conversely, the binding was not due to a non-specific adhesive property of the midguts, because a variety of other cell types, including untransformed P. gallinaceum zygotes or macrogametes, did not show similar binding to the midguts. High concentrations of glycosylated (fetuin, orosomucoid, ovalbumin) or non-glycosylated (bovine serum albumin) proteins, added as non-specific competitors, failed to compete with the ookinetes in binding assays. It was also found that the adhesion of ookinetes to the midgut surface is necessary for sporogonic development of the parasite in the mosquito. Antibodies and other reagents that blocked adhesion in vitro also reduced oocyst formation when these reagents were combined with mature ookinetes and fed to mosquitoes. Chemical modification of the midguts with sodium periodate at pH 5.5 destroyed adhesion, indicating that the ookinete binds to a carbohydrate ligand on the surface of the midgut. The ligand is sensitive to periodate concentrations of &lt;1 mmol litre-1, suggesting that it may contain sialic-acid-like sugars. Furthermore, free N-acetylneuraminic acid competed with the ookinetes in binding assays, while other monosaccharides had no effect. However, in agreement with the current belief that adult insects do not contain sialic acids, no sialic acids were detected in mosquito midguts using the most sensitive HPLC-based fluorometric assay currently available. It is postulated that a specific carbohydrate group is used by the ookinete to recognize the midgut epithelium and to attach to its surface. This is the 1st receptor-ligand interaction demonstrated for the ookinete stage of a malaria parasite. Further characterization of the midgut ligand and its parasite counterpart may lead to novel strategies of blocking oocyst development in the mosquito.
KW  - adhesion
KW  - albumins
KW  - antibodies
KW  - binding
KW  - biochemistry
KW  - epithelium
KW  - host parasite relationships
KW  - intestines
KW  - ligands
KW  - malaria
KW  - midgut
KW  - oocysts
KW  - ookinetes
KW  - parasites
KW  - proteins
KW  - sialic acids
KW  - Aedes aegypti
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990503696&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Purification and cloning of the salivary peroxidase/catechol oxidase of the mosquito Anopheles albimanus.
AU  - Ribeiro, J. M. C.
AU  - Valenzuela, J. G.
JO  - Journal of Experimental Biology
JF  - Journal of Experimental Biology
Y1  - 1999///
VL  - 202
IS  - 7
SP  - 809
EP  - 816
SN  - 0022-0949
AD  - Ribeiro, J. M. C.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive MSC-0425, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990503606.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 903-99-0. 
N2  - Salivary homogenates of the adult female mosquito Anopheles albimanus have been shown previously to contain a vasodilatory activity associated with a catechol oxidase/peroxidase activity. A study was carried out in which the salivary peroxidase was purified using high-performance liquid chromatography. The pure enzyme was able to relax rabbit aortic rings pre-constricted with norepinephrine. The peroxidase had a relative molecular mass of 66 907 as estimated by mass spectrometry. Oligonucleotide probes for isolation of cDNA clones derived from the salivary gland mRNA from female mosquitoes were designed using amino-terminal sequencing. The full sequence of the cDNA demonstrated homology between A. albimanus salivary peroxidase and several members of the myeloperoxidase gene family. A close comparison of A. albimanus salivary peroxidase with canine myeloperoxidase, for which the crystal structure is known, showed that all six disulfide bridges were conserved and demonstrated identity for all five residues associated with a Ca2+-binding site. In addition, 16 of 26 residues shown to be in close proximity to the haeme moiety in the canine myeloperoxidase were identical. It is concluded that the salivary peroxidase of A. albimanus belongs to the myeloperoxidase gene family. Other possible functions for this molecule in blood feeding are discussed.
KW  - clones
KW  - complementary DNA
KW  - messenger RNA
KW  - peroxidase
KW  - residues
KW  - salivary glands
KW  - Anopheles
KW  - Anopheles albimanus
KW  - Culicidae
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - cDNA
KW  - cloning
KW  - mosquitoes
KW  - mRNA
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990503606&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Salivary glands of the sand fly Phlebotomus papatasi contain pharmacologically active amounts of adenosine and 5′-AMP.
AU  - Ribeiro, J. M. C.
AU  - Katz, O.
AU  - Pannell, L. K.
AU  - Waitumbi, J.
AU  - Warburg, A.
JO  - Journal of Experimental Biology
JF  - Journal of Experimental Biology
Y1  - 1999///
VL  - 202
IS  - 11
SP  - 1551
EP  - 1559
SN  - 0022-0949
AD  - Ribeiro, J. M. C.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Building 4, Room 126, 4 Center Drive MSC-0425, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990504819.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 58-61-7, 61-19-8.  Subject Subsets: Medical & Veterinary Entomology
N2  - Salivary gland homogenates of P. papatasi contain large amounts of adenosine and 5′-AMP, of the order of 1 nmol per pair of glands, as demonstrated by liquid chromatography, ultraviolet spectrometry, mass spectrometry and bioassays. These purines, 75-80% of which are secreted from the glands following a blood meal, have vasodilatory and anti-platelet activities and probably help the fly to obtain a blood meal. Salivary 5′-AMP is also responsible for the previously reported protein phosphatase inhibitor in the salivary glands of P. papatasi, which is shown to be artefactual in nature as a result of allosteric modification by AMP of the phosphatase substrate used (phosphorylase a).
KW  - adenosine
KW  - AMP
KW  - biochemistry
KW  - blood meal
KW  - saliva
KW  - salivary glands
KW  - Diptera
KW  - Phlebotominae
KW  - Phlebotomus papatasi
KW  - Psychodidae
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Psychodidae
KW  - Diptera
KW  - Phlebotomus
KW  - Phlebotominae
KW  - adenosine monophosphate
KW  - salivary secretions
KW  - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504819&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Preclinical efficacy studies of green and black tea extracts (44367).
AU  - Steele, V. E.
AU  - Bagheri, D.
AU  - Balentine, D. A.
AU  - Boone, C. W.
AU  - Rajendra Mehta
AU  - Morse, M. A.
AU  - Sheela Sharma
AU  - Sigman, C. C.
AU  - Stoner, G. D.
AU  - Wargovich, M. J.
AU  - Weisburger, J. H.
AU  - Zhu SongYun
AU  - Kelloff, G. J.
A2  - Weisburger, J. H.
JO  - Proceedings of the Society for Experimental Biology and Medicine
JF  - Proceedings of the Society for Experimental Biology and Medicine
Y1  - 1999///
VL  - 220
IS  - 4
SP  - 210
EP  - 212
SN  - 0037-9727
AD  - Steele, V. E.: National Cancer Institute (NCI), Chemoprevention Branch, 9000 Rockville Pike, Executive Plaza North, Suite 201, Bethesda, MD 20892-7322, USA.
N1  - Accession Number: 19991407478.  Publication Type: Journal Article; Conference paper; Journal article.  Language: English.  Number of References: 5 ref. Registry Number: 9007-49-2.  Subject Subsets: Human Nutrition
N2  - Results are presented from in vitro mechanistic and cell transformation assays screening for the cancer chemopreventive efficacy of flavanol compounds of tea.
KW  - antioxidants
KW  - DNA
KW  - drug therapy
KW  - flavanols
KW  - free radicals
KW  - in vitro
KW  - neoplasms
KW  - phenolic compounds
KW  - tea
KW  - Camellia sinensis
KW  - Camellia
KW  - Theaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - cancers
KW  - chemotherapy
KW  - deoxyribonucleic acid
KW  - epigallocatechin gallate
KW  - Crop Produce (QQ050) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Polyethylene glycol-mediated infection of non-permissive mammalian cells with Semliki Forest virus: application to signal transduction studies.
AU  - Ramachandran Arudchandran
AU  - Brown, M. J.
AU  - Song, J. S.
AU  - Wank, S. A.
AU  - Haleem-Smith, H.
AU  - Rivera, J.
JO  - Journal of Immunological Methods
JF  - Journal of Immunological Methods
Y1  - 1999///
VL  - 222
IS  - 1/2
SP  - 197
EP  - 208
SN  - 0022-1759
AD  - Ramachandran Arudchandran: Section on Chemical Immunology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990502661.  Publication Type: Journal Article.  Language: English.  Number of References: 24 ref. Registry Number: 37341-29-0, 308067-57-4, 25322-68-3, 9026-43-1, 60-18-4. 
N2  - Semliki Forest virus (SFV) vectors allow the subcloning of a gene of interest directly in the expression vector, thus avoiding the need to select and purify viral recombinants, making this viral expression system attractive over many others for mammalian protein expression. A novel and generally applicable method for infection of non-permissive mammalian cells with SFV is described, that greatly enhances the utility of this expression system. It was demonstrated that the hygroscopic polymer poly (ethylene glycol), PEG, promotes the infectivity of cells by SFV under conditions that did not promote cell-cell fusion. It was also found that the PEG-induced infection and expression of an exogenous protein (green fluorescent protein, GFP) did not elevate the basal tyrosine kinase activity, induce a stress-activated responses, or result in aberrant cell responses. Expression of GFP tagged-Vav, an activator of stress-activated protein kinase (SAPK/JNK), resulted in the expected induction of JNK activity and in the normal redistribution of Vav in response to engagement of the high affinity receptor for IgE (FcεRI). Thus, the findings that PEG allows the infection of non-permissive cells by SFV makes this system extremely attractive for expression of proteins in mammalian cells, and studies on signal transduction and cellular localization in immune and non-immune cells.
KW  - arboviruses
KW  - cells
KW  - IgE
KW  - immunoglobulins
KW  - infectivity
KW  - kinases
KW  - localization
KW  - polyethylene glycol
KW  - protein kinase
KW  - proteins
KW  - transduction
KW  - tyrosine
KW  - vectors
KW  - Semliki Forest virus
KW  - Alphavirus
KW  - Togaviridae
KW  - positive-sense ssRNA viruses
KW  - ssRNA viruses
KW  - RNA viruses
KW  - viruses
KW  - arthropod-borne viruses
KW  - gamma-globulins
KW  - immune globulins
KW  - polyoxyethylene
KW  - reagin
KW  - reaginic antibodies
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cytokine and immunoglobulin concentrations in cervical secretions: reproducibility of the Weck-cel collection instrument and correlates of immune measures.
AU  - Hildesheim, A.
AU  - McShane, L. M.
AU  - Schiffman, M.
AU  - Bratti, M. C.
AU  - Rodriguez, A. C.
AU  - Herrero, R.
AU  - Morera, L. A.
AU  - Cardenas, F.
AU  - Saxon, L.
AU  - Bowman, F. P.
AU  - Crowley-Nowick, P. A.
JO  - Journal of Immunological Methods
JF  - Journal of Immunological Methods
Y1  - 1999///
VL  - 225
IS  - 1/2
SP  - 131
EP  - 143
SN  - 0022-1759
AD  - Hildesheim, A.: Interdisciplinary Studies Section, Environmental Epidemiology Branch, DCEG, National Cancer Institute, 6130 Executive Blvd, EPN 443, Bethesda, MD 20892-7374, USA.
N1  - Accession Number: 19992009450.  Publication Type: Journal Article.  Language: English.  Number of References: 34 ref. Registry Number: 308067-58-5, 308067-57-4. 
N2  - The reproducibility of the Weck-cel sponge used to collect cervical secretions for immunological assessment was assessed. Correlates of immunity were also examined as part of the investigation. Two cervical secretion specimens were collected sequentially from each of 120 women using Weck-cel sponges. Cervical secretions were collected prior to Pap smear sampling to avoid blood contamination. At the laboratory, the duplicate specimens were weighed and tested in replicate wells to determine the concentration of 2 cytokines (IL-10 and IL-12) and 2 immunoglobulin isotypes (IgG and IgA). IL-12, total IgG, and total IgA showed a strong correlation between samples from the same woman ranging from 0.78 to 0.84. Kappa coefficients obtained after categorising assay results ranged from 0.62 to 0.67. Variance components analysis suggested that 69% to 85% of the variance observed was accounted for by between-women variance, with the remaining variability attributed to variation between samples collected from the same woman. IL-10 results were less reproducible than those obtained from the other assays examined, suggesting problems with the assay used to measure this cytokine rather than with the Weck-cel sampling instrument. Various factors were found to significantly correlate with cytokine and immunoglobulin measures at the cervix. Age and reproductive status were associated with all 4 immune measures; women over 50 years of age and those who were postmenopausal had increased concentrations of IL-10, IL-12, IgG, and IgA. Haemoglobin concentrations were positively correlated with IgG and IL-10 concentrations, but not with IgA or IL-12 concentrations, suggesting local production of IgA and IL-12. The concentration of all immune measures decreased with increasing volume of collection. No significant association was observed between time from collection to freezing of specimens and concentrations of cytokines or immunoglobulins. Overall, the data suggest that measurement of immunological parameters in cervical secretions collected using Weck-cel sponges are reproducible. In addition, various correlates of cytokine and immunoglobulin concentrations were identified.
KW  - cervix
KW  - cytokines
KW  - IgA
KW  - IgG
KW  - immunoglobulins
KW  - methodology
KW  - sampling
KW  - secretions
KW  - techniques
KW  - women
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - gamma-globulins
KW  - immune globulins
KW  - methods
KW  - sampling techniques
KW  - Host Resistance and Immunity (HH600) 
KW  - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW  - Techniques and Methodology (ZZ900) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Characterization of the glyceraldehyde-3-phosphate gene and the use of its promoter for heterologous expression in Cryptococcus neoformans, a human pathogen.
AU  - Varma, A.
AU  - Kwon-Chung, K. J.
JO  - Gene
JF  - Gene
Y1  - 1999///
VL  - 232
IS  - 2
SP  - 155
EP  - 163
SN  - 0378-1119
AD  - Varma, A.: Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001202106.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 9007-49-2, 37250-87-6, 9001-50-7, 9028-92-6.  Subject Subsets: Medical & Veterinary Mycology
N2  - The GPD gene encoding glyceraldehyde-3-phosphate dehydrogenase was isolated from C. neoformans. The gene contained 11 introns, differing from the conserved intron positions found in the GPD genes of Basidiomycetes. The predicted amino-acid sequence of this gene was very similar to that reported from GPD proteins of other Basidiomycetes. The promoter region of the C. neoformans GPD gene was similar to those of other Basidiomycetes. Plasmid constructs containing up to 1600 base pairs upstream of the native GPD open reading frame were used to express either the native URA5 gene in a ura5 mutant or the heterologous hphI gene (a bacterial gene that confers resistance to the aminoglycoside hygromycin) in a wild-type strain of C. neoformans. Transformation frequencies resulting from the plasmid-borne Gpdp::URA5 gene were at levels similar to those of the native URA5, which suggested that all the sequences necessary for proper expression were present. Transformation frequencies using the Gpdp::hphI gene constructs were poor. However, addition of DNA sequences flanking the 3′-end of an native C. neoformans gene significantly improved the transformation frequencies resulting from the expression of the heterologous hphI gene.
KW  - DNA
KW  - enzymes
KW  - gene expression
KW  - genes
KW  - genetics
KW  - glyceraldehyde-3-phosphate dehydrogenase
KW  - introns
KW  - nucleotide sequences
KW  - open reading frames
KW  - promoters
KW  - proteins
KW  - yeasts
KW  - Cryptococcus neoformans
KW  - fungi
KW  - eukaryotes
KW  - Cryptococcus (Fungi)
KW  - Tremellaceae
KW  - Tremellales
KW  - Tremellomycetes
KW  - Agaricomycotina
KW  - Basidiomycota
KW  - deoxyribonucleic acid
KW  - DNA sequences
KW  - fungus
KW  - ORFs
KW  - promoter region
KW  - promoter sequences
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans.
AU  - Miyazaki, Y.
AU  - Geber, A.
AU  - Miyazaki, H.
AU  - Falconer, D.
AU  - Parkinson, T.
AU  - Hitchcock, C.
AU  - Grimberg, B.
AU  - Nyswaner, K.
AU  - Bennett, J. E.
JO  - Gene
JF  - Gene
Y1  - 1999///
VL  - 236
IS  - 1
SP  - 43
EP  - 51
SN  - 0378-1119
AD  - Miyazaki, Y.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH. 10 Center Drive, Bethesda, MD 20892, USA.
N1  - Accession Number: 20001201517.  Publication Type: Journal Article.  Language: English.  Number of References: 32 ref. Registry Number: 59-23-4.  Subject Subsets: Medical & Veterinary Mycology
N2  - The C-5 sterol desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from C. albicans by homology with the Saccharomyces cerevisiae ERG3. The ERG3 ORF contained 1158 bp and encoded 386 deduced amino acids. The clone was used to transform a gal1 mutant derived from the Darlington strain of C. albicans, using galactose selection. The Darlington strain is known to lack Δ5,6 sterols, i.e. to have an erg3 phenotype. The transformant (CDTR1) contained 6 tandem integrated ERG3GAL1 repeats, had double the abundance of ERG3 transcript found in the host strain, and synthesized ergosterol, a Δ5,6 sterol. The Darlington strain had an abundance of ERG3 transcript. Both ERG3 alleles in Darlington were cloned and sequenced in order to look for changes that might explain the erg3 phenotype. One allele, called Dar-2, contained a stop codon in place of tryptophan-292. The other ERG3 allele, called Dar-1, had changes in 3 amino acids, 2 of which were conserved in 3 fungal and one plant species. EcoRI genomic fragments containing ERG3 from the Dar-1 allele and from B311, the wild-type strain, were inserted into the plasmid pRS316 and used to transform a Saccharomyces cerevisiae erg3,ura3 mutant using uracil selection. The 4.1 kb ERG3 fragments from the B311 and Dar-1 both contained 1.4 kb 5′ and 1.5 kb 3′ flanking sequences around the coding region. Transformants with ERG3 from B311 but not from Dar-1 showed restored ergosterol synthesis. One or more of these 3 deduced amino acids in the Dar-1 allele of ERG3 appeared critical for function.
KW  - alleles
KW  - amino acids
KW  - biosynthesis
KW  - DNA cloning
KW  - galactose
KW  - genes
KW  - genetics
KW  - nucleotide sequences
KW  - phenotypes
KW  - sterols
KW  - yeasts
KW  - Candida albicans
KW  - Saccharomyces cerevisiae
KW  - Saccharomycetaceae
KW  - fungi
KW  - eukaryotes
KW  - Candida
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Ascomycota
KW  - Saccharomyces
KW  - Saccharomycetaceae
KW  - DNA sequences
KW  - fungus
KW  - Hyphomycetes
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001201517&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes.
AU  - Gong DaWei
AU  - He YuFang
AU  - Reitman, M. L.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1999///
VL  - 256
IS  - 1
SP  - 27
EP  - 32
SN  - 0006-291X
AD  - Gong DaWei: Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1770, USA.
N1  - Accession Number: 19991411968.  Publication Type: Journal Article.  Language: English.  Number of References: 33 ref. Subject Subsets: Human Nutrition
KW  - cell cultures
KW  - fat
KW  - genes
KW  - genetics
KW  - genomes
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - uncoupling protein
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411968&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Thiamine deficiency in vivo produces fiber cell degeneration in mouse lenses.
AU  - Frederikse, P. H.
AU  - Farnsworth, P.
AU  - Zigler, J. S., Jr.
JO  - Biochemical and Biophysical Research Communications
JF  - Biochemical and Biophysical Research Communications
Y1  - 1999///
VL  - 258
IS  - 3
SP  - 703
EP  - 707
SN  - 0006-291X
AD  - Frederikse, P. H.: Building 6, Room 237, Laboratory on Mechanisms of Ocular Disease, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2735, USA.
N1  - Accession Number: 20001416659.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref. Registry Number: 59-43-8.  Subject Subsets: Human Nutrition
KW  - deficiency
KW  - degeneration
KW  - eye lens
KW  - eyes
KW  - thiamin
KW  - mice
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - aneurin
KW  - thiamine
KW  - vitamin B1
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001416659&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Apolipoprotein B stimulates formation of monocyte-macrophage surface-connected compartments and mediates uptake of low density lipoprotein-derived liposomes into these compartments.
AU  - Kruth, H. S.
AU  - Zhang WeiYang
AU  - Skarlatos, S. I.
AU  - Chao FeiFei
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1999///
VL  - 274
IS  - 11
SP  - 7495
EP  - 7500
SN  - 0021-9258
AD  - Kruth, H. S.: Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 19991407271.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Subject Subsets: Human Nutrition
N2  - Much of the cholesterol that accumulates in atherosclerotic plaques is found within monocyte-macrophages transforming these cells into "foam cells." Native LDL does not cause foam cell formation. Treatment of LDL with cholesterol esterase converts LDL into cholesterol-rich liposomes having &gt;90% cholesterol in unesterified form. Similar cholesterol-rich liposomes are found in early developing atherosclerotic plaques surrounding foam cells. Cholesterol-rich liposomes produced from cholesterol esterase-treated LDL can cause human monocyte-macrophage foam cell formation inducing a 3-5-fold increase in macrophage cholesterol content of which &gt;60% is esterified. Although cytochalasin D inhibited LDL liposome-induced macrophage cholesteryl ester accumulation, LDL liposomes did not enter macrophages by phagocytosis. Rather, the LDL liposomes induced and entered surface-connected compartments within the macrophages, a unique endocytic pathway in these cells, referred to as patocytosis by the authors. LDL liposome apoB rather than LDL liposome lipid mediated LDL liposome uptake by macrophages. This was shown by the findings that: protease treatment of the LDL liposomes prevented macrophage cholesterol accumulation; liposomes prepared from LDL lipid extracts did not cause macrophage cholesterol accumulation; and purified apoB induced and accumulated within macrophage surface-connected compartments. Although apoB mediated the macrophage uptake of LDL liposomes, this uptake did not occur through LDL, LDL receptor-related protein, or scavenger receptors. Also, LDL liposome uptake was not sensitive to treatment of macrophages with trypsin or heparinase. Cholesterol esterase-mediated transformation of LDL into cholesterol-rich liposomes is an LDL modification that: stimulates uptake of LDL cholesterol by apoB-dependent endocytosis into surface-connected compartments; and causes human monocyte-macrophage foam cell formation.
KW  - apolipoproteins
KW  - in vitro
KW  - liposomes
KW  - low density lipoprotein
KW  - macrophages
KW  - monocytes
KW  - uptake
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Vesicular ATPase-overexpressing cells determine the distribution of malaria parasite oocysts on the midguts of mosquitoes.
AU  - Cociancich, S. O.
AU  - Park, S. S.
AU  - Fidock, D. A.
AU  - Shahabuddin, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1999///
VL  - 274
IS  - 18
SP  - 12650
EP  - 12655
SN  - 0021-9258
AD  - Cociancich, S. O.: Medical Entomology Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bldg. 4, Rm B2-39, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 19990805456.  Publication Type: Journal Article.  Language: English.  Number of References: 21 ref. Registry Number: 9000-83-3.  Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2  - In Plasmodium-infected mosquitoes, oocysts are preferentially located at the posterior half of the posterior midgut. Because mosquitoes rest vertically after feeding, the effect of gravity on the ingested blood has been proposed as the cause of such a biased distribution. P. gallinaceum oocyst distribution was examined in the midguts of Aedes aegypti that were continuously rotated to nullify the effect of gravity and it was found that the typical pattern of oocyst distribution did not change. Invasion of the midgut epithelium by ookinetes was similarly found to be biased toward the posterior part of the posterior midgut. The effect of the distribution of vesicular ATPase (V-ATPase)-overexpressing cells that Plasmodium ookinetes preferentially use to cross the midgut epithelium on the distribution of oocysts was investigated. An antiserum raised against recombinant A. aegypti V-ATPase B subunit indicated that most V-ATPase-overexpressing cells in A. aegypti and Anopheles gambiae are localized at the posterior part of the posterior midgut. It was concluded that the typical distribution of oocysts on the mosquito midgut is attributable to the presence and the spatial distribution of the V-ATPase-overexpressing cells in the midgut epithelium.
KW  - adenosinetriphosphatase
KW  - cells
KW  - epithelium
KW  - host parasite relationships
KW  - midgut
KW  - oocysts
KW  - ookinetes
KW  - parasites
KW  - spatial distribution
KW  - Aedes aegypti
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Plasmodium gallinaceum
KW  - protozoa
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - ATPase
KW  - mosquitoes
KW  - parasite host relationships
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805456&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Specificity of ascorbate analogs for ascorbate transport: synthesis and detection of [125I]6-deoxy-6-iodo-L-ascorbic acid and characterization of its ascorbate-specific transport properties.
AU  - Rumsey, S. C.
AU  - Welch, R. W.
AU  - Garraffo, H. M.
AU  - Ge Ping
AU  - Lu ShouFu
AU  - Crossman, A. T.
AU  - Kirk, K. L.
AU  - Levine, M.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1999///
VL  - 274
IS  - 33
SP  - 23215
EP  - 23222
SN  - 0021-9258
AD  - Rumsey, S. C.: Molecular and Clinical Nutrition Section, Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1372, USA.
N1  - Accession Number: 19991415525.  Publication Type: Journal Article.  Language: English.  Number of References: 26 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Cellular ascorbic acid accumulation occurs in vitro by two distinct mechanisms: transport of ascorbate itself or transport and subsequent intracellular reduction of its oxidized product, dehydroascorbic acid. It is unclear which mechanism predominates in vivo. An easily detectable compound resembling ascorbate but not dehydroascorbic acid could be a powerful tool to distinguish the two transport activities. To identify compounds, 21 ascorbate analogues were tested for inhibition of ascorbate or dehydroascorbic acid transport in human fibroblasts. The most effective analogues, competitive inhibitors of ascorbate transport with Ki values of 3 µM, were 6-deoxy-6-bromo-, 6-deoxy-6-chloro-, and 6-deoxy-6-iodo-L-ascorbate. No analogue inhibited dehydroascorbic acid transport. Using substitution chemistry, [125I]6-deoxy-6-iodo-L-ascorbate (1.4×104 mCi/mmol) was synthesized. HPLC detection methods were developed for radiolabelled and nonradiolabelled compounds, and transport kinetics of both compounds were characterized. Transport was sodium-dependent, inhibited by excess ascorbate, and similar to that of ascorbate. Transport of oxidized ascorbate and oxidized 6-deoxy-6-iodo-L-ascorbate was investigated using Xenopus laevis oocytes expressing glucose transporter isoform GLUT1 or GLUT3. Oxidation of ascorbate or its analogue in media increased uptake of ascorbate in oocytes by 6-13-fold compared with control but not that of 6-deoxy-6-iodo-L-ascorbate. Therefore, 6-deoxy-6-iodo-L-ascorbate, although an effective inhibitor of ascorbate transport, either in its reduced or oxidized form was not a substrate for dehydroascorbic acid transport. Thus, radiolabelled and nonradiolabelled 6-deoxy-6-iodo-L-ascorbate provide a new means for discriminating dehydroascorbic acid and ascorbate transport in ascorbate recycling.
KW  - analogues
KW  - ascorbic acid
KW  - characterization
KW  - detection
KW  - fibroblasts
KW  - in vitro
KW  - inhibition
KW  - inhibitors
KW  - kinetics
KW  - properties
KW  - recycling
KW  - synthesis
KW  - transport
KW  - uptake
KW  - man
KW  - Xenopus laevis
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Xenopus
KW  - Pipidae
KW  - Anura
KW  - Amphibia
KW  - analogs
KW  - transportation
KW  - vitamin C
KW  - Animal Models of Human Nutrition (VV140) 
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Physiology of Human Nutrition (VV120) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415525&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Neuronal sensitivity to tetanus toxin requires gangliosides.
AU  - Williamson, L. C.
AU  - Bateman, K. E.
AU  - Clifford, J. C. M.
AU  - Neale, E. A.
JO  - Journal of Biological Chemistry
JF  - Journal of Biological Chemistry
Y1  - 1999///
VL  - 274
IS  - 35
SP  - 25173
EP  - 25180
SN  - 0021-9258
AD  - Williamson, L. C.: Laboratory of Developmental Neurobiology, NICHHD, National Institutes of Health, Bethesda, MD 20892-4480, USA.
N1  - Accession Number: 19991202894.  Publication Type: Journal Article.  Language: English.  Number of References: 44 ref.
N2  - Tetanus toxin binding and action in spinal cord cell cultures grown in the presence of fumonisin B1, an inhibitor of ganglioside synthesis, was examined. Mouse spinal cord neurons grown for 3 weeks in culture in 20 µM fumonisin B1 developed dendrites, axons, and synaptic terminals similar to untreated neurons, even though thin layer chromatography showed a &gt;90% inhibition of ganglioside synthesis. Absence of tetanus and cholera toxin binding by toxin-horseradish peroxidase conjugates or immunofluorescence further indicated loss of mono- and polysialogangliosides. In contrast to control cultures, tetanus toxin added to fumonisin B1-treated cultures did not block potassium-stimulated glycine release, inhibit activity-dependent uptake of FM1-43, or abolish immunoreactivity for vesicle-associated membrane protein, the toxin substrate. Supplementing fumonisin B1-treated cultures with mixed brain gangliosides completely restored the ability of tetanus toxin to bind to the neuronal surface and to block neurotransmitter release. These data demonstrate that fumonisin B1 protects against toxin-induced synaptic blockade and that gangliosides are a necessary component of the receptor mechanism for tetanus toxin.
KW  - bacterial toxins
KW  - cell cultures
KW  - cholera
KW  - fumonisins
KW  - gangliosides
KW  - inhibition
KW  - mycotoxins
KW  - neurons
KW  - neurotransmitters
KW  - paralysis
KW  - receptors
KW  - tetanus
KW  - toxins
KW  - Vibrio cholerae
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - bacterium
KW  - fungal toxins
KW  - lockjaw
KW  - nerve cells
KW  - neurones
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202894&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats.
AU  - Horská, A.
AU  - Brant, L. J.
AU  - Ingram, D. K.
AU  - Hansford, R. G.
AU  - Roth, G. S.
AU  - Spencer, R. G. S.
JO  - American Journal of Physiology
JF  - American Journal of Physiology
Y1  - 1999///
VL  - 276
IS  - 4
SP  - E766
EP  - E773
SN  - 0002-9513
AD  - Horská, A.: Nuclear Magnetic Resonance Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
N1  - Accession Number: 19991407833.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Registry Number: 67-07-2.  Subject Subsets: Human Nutrition
N2  - The hypothesis that long-term caloric [energy] restriction and exercise would have beneficial effects on muscle bioenergetics and performance in the rat was examined. Each of these interventions is known to increase longevity and bioenergetic improvements are thought to be important in this phenomenon. Rats that underwent long-term caloric restriction and were sedentary, ad libitum-fed rats permitted to exercise by daily spontaneous wheel running (AE) and the combination of the dietary and exercise interventions (RE) were studied. Ad libitum-fed, sedentary rats comprised the control group. 31P NMR spectra of the gastrocnemius muscle (GM) were collected in vivo at rest and during 2 periods of electrical stimulation. Neither caloric restriction nor exercise affected the ratio of phosphocreatine to ATP or pH at rest. During the first stimulation and after recovery, the RE group had a smaller decline in pH than did the other groups (P&lt;0.05). During the second period of stimulation, the decrease in pH was much smaller in all groups than during the first stimulation, with no differences observed among the groups. The combination of caloric restriction and exercise resulted in an attenuation in the decline in developed force during the second period of stimulation (P&lt;0.05). A biochemical correlate of this was a significantly higher concentration of citrate synthase in the GM samples from the RE rats compared with the AE rats (32.7±5.4 vs. 17.6±5.7 µmol min-1 g-1; P&lt;0.05). It is concluded that there is a synergistic effect of long-term caloric restriction and free exercise on muscle bioenergetics during electrical stimulation.
KW  - bioenergetics
KW  - energy intake
KW  - energy relations
KW  - exercise
KW  - kinetics
KW  - metabolism
KW  - muscles
KW  - pH
KW  - phosphocreatine
KW  - restricted feeding
KW  - rats
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - creatine phosphate
KW  - hydrogen ion concentration
KW  - potential of hydrogen
KW  - Animal Nutrition (Physiology) (LL510) 
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women.
AU  - Culnane, M.
AU  - Fowler, M. G.
AU  - Lee, S. S.
AU  - McSherry, G.
AU  - Brady, M.
AU  - O'Donnell, K.
AU  - Mofenson, L.
AU  - Gortmaker, S. L.
AU  - Shapiro, D. E.
AU  - Scott, G.
AU  - Jimenez, E.
AU  - Moore, E. C.
AU  - Diaz, C.
AU  - Flynn, P. M.
AU  - Cunningham, B.
AU  - Oleske, J.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1999///
VL  - 281
IS  - 2
SP  - 151
EP  - 157
SN  - 0098-7484
AD  - Culnane, M.: MS, CRNP, Pediatric Medicine Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-7620, USA.
N1  - Accession Number: 19992002055.  Publication Type: Journal Article.  Corporate Author: USA, Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams Language: English.  Number of References: 21 ref. Registry Number: 30516-87-1.  Subject Subsets: Public Health
N2  - To evaluate the long-term effects of in utero exposure to zidovudine vs placebo among a randomized cohort of uninfected children, a prospective cohort study was conducted based on data collected during Pediatric AIDS Clinical Trials Group Protocol 076, a perinatal zidovudine HIV prevention trial, and Protocol 219, a long-term observational protocol. 234 uninfected children born in the USA to 230 HIV-infected women enrolled in Protocol 076 and followed up through February 28, 1997, in Protocol 219 (122 in the zidovudine group and 112 in the placebo group) were studied. Physical growth measurements, immunological parameters, cognitive/developmental function, occurrence of neoplasms, and mortality data were assessed every 6 months for children &lt;24 months and yearly thereafter or as clinically indicated. Baseline echocardiogram and funduscopic evaluations were collected before 36 months of age. Median age of children at time of last follow-up visit was 4.2 years (range, 3.2-5.6 years). There were no significant differences between children exposed to zidovudine and those who received placebo in terms of sequential data on lymphocyte subsets; weight, height, and head circumference z scores; and cognitive/developmental function. No deaths or malignancies occurred. Two children (both exposed to zidovudine) are being followed up for abnormal, unexplained ophthalmic findings. One child exposed to zidovudine had a mild cardiomyopathy on echocardiogram at the age of 48 months; the child is clinically asymptomatic. It is concluded that no adverse effects were observed in HIV-uninfected children with in utero and neonatal exposure to zidovudine followed up for as long as 5.6 years.
KW  - adverse effects
KW  - children
KW  - exposure
KW  - eyes
KW  - fetus
KW  - growth
KW  - health
KW  - heart
KW  - human immunodeficiency viruses
KW  - immunity
KW  - infants
KW  - zidovudine
KW  - USA
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - adverse reactions
KW  - AZT
KW  - foetus
KW  - human immunodeficiency virus
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002055&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus.
AU  - Henderson, D. K.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1999///
VL  - 281
IS  - 10
SP  - 931
EP  - 936
SN  - 0098-7484
AD  - Henderson, D. K.: Office of the Deputy Director for Clinical Care, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992003429.  Publication Type: Journal Article.  Language: English.  Number of References: 63 ref. Subject Subsets: Public Health
KW  - animal models
KW  - antiviral agents
KW  - chemoprophylaxis
KW  - clinical aspects
KW  - efficacy
KW  - exposure
KW  - health care workers
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - occupational hazards
KW  - reviews
KW  - safety
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003429&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Criteria and recommendations for vitamin C intake.
AU  - Levine, M.
AU  - Rumsey, S. C.
AU  - Daruwala, R.
AU  - Park, J. B.
AU  - Wang YaoHui
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1999///
VL  - 281
IS  - 15
SP  - 1415
EP  - 1423
SN  - 0098-7484
AD  - Levine, M.: National Institutes of Health, Bldg 10, Room 4D52, MSC1372, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991407535.  Publication Type: Journal Article.  Language: English.  Number of References: 107 ref. Registry Number: 50-81-7.  Subject Subsets: Human Nutrition
N2  - Recommendations for vitamin C [ascorbic acid] intake are under revision by the Food and Nutrition Board of the National Academy of Sciences. Since 1989 when the last recommended dietary allowance (RDA) of 60 mg was published, extensive biochemical, molecular, epidemiologic, and clinical data have become available. New recommendations can be based on the following 9 criteria: dietary availability, steady-state concentrations in plasma in relationship to dose, steady-state concentrations in tissues in relationship to dose, bioavailability, urine excretion, adverse effects, biochemical and molecular function in relationship to vitamin concentration, direct beneficial effects and epidemiologic observations in relationship to dose, and prevention of deficiency. These criteria were applied to the Food and Nutrition Boards new guidelines, the Dietary Reference Intakes, which include 4 reference values. The estimated average requirement (EAR) is the amount of nutrient estimated to meet the requirement of half the healthy individuals in a life-stage and gender group. Based on an EAR of 100 mg/day of vitamin C, the RDA is proposed to be 120 mg/day. If the EAR cannot be determined, an adequate intake (AI) amount is recommended instead of an RDA. The AI was estimated to be either 200 mg/day from 5 servings of fruits and vegetables or 100 mg/day of vitamin C to prevent deficiency with a margin of safety. The final classification, the tolerable upper intake level, is the highest daily level of nutrient intake that does not pose risk or adverse health effects to almost all individuals in the population. This amount is proposed to be less than 1 g of vitamin C daily. Physicians can tell patients that 5 servings of fruits and vegetables per day may be beneficial in preventing cancer and providing sufficient vitamin C intake for healthy people, and that 1 g or more of vitamin C may have adverse consequences in some people.
KW  - ascorbic acid
KW  - dietary guidelines
KW  - recommended dietary allowances
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - RDA
KW  - recommended dietary intakes
KW  - United States of America
KW  - vitamin C
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407535&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis.
AU  - Whitcup, S. M.
AU  - Fortin, E.
AU  - Lindblad, A. S.
AU  - Griffiths, P.
AU  - Metcalf, J. A.
AU  - Robinson, M. R.
AU  - Manischewitz, J.
AU  - Baird, B.
AU  - Perry, C.
AU  - Kidd, I. M.
AU  - Vrabec, T.
AU  - Davey, R. T., Jr.
AU  - Falloon, J.
AU  - Walker, R. E.
AU  - Kovacs, J. A.
AU  - Lane, H. C.
AU  - Nussenblatt, R. B.
AU  - Smith, J.
AU  - Masur, H.
AU  - Polis, M. A.
JO  - JAMA, Journal of the American Medical Association
JF  - JAMA, Journal of the American Medical Association
Y1  - 1999///
VL  - 282
IS  - 17
SP  - 1633
EP  - 1637
SN  - 0098-7484
AD  - Whitcup, S. M.: National Eye Institute, National Institutes of Health, 10/105221, 10 Center Dr, MSC 1863, Bethesda, MD 20892-1863, USA.
N1  - Accession Number: 20002004812.  Publication Type: Journal Article.  Language: English.  Number of References: 28 ref. Subject Subsets: Public Health
N2  - A prospective nonrandomized interventional trial was conducted at the Clinical Center of the National Institutes of Health, Bethesda, Maryland, USA, during July 1997 to August 1999, to determine whether patients who were taking highly active antiretroviral therapy (HAART) and who had stable cytomegalovirus (CMV) retinitis could safely discontinue anti-CMV therapy without reactivation of their retinitis or increase in human immunodeficiency virus (HIV) viral load. The study comprised 14 patients with stable CMV retinitis and HIV infection and CD4+ cell counts &gt;0.15 × 109/litre and being treated with systemic anti-CMV medications and HAART. Specific anti-CMV therapy was discontinued. The main outcome measures were reactivation of CMV retinitis, development of extraocular CMV infection, detection of CMV in blood and urine, HIV burden, immunological function, quality of life, morbidity and mortality. 12 (89.7%) of 14 patients had evidence of immune recovery uveitis before anti-CMV drugs were discontinued. No patient had reactivation of CMV retinitis or development of extraocular CMV disease during mean follow-up of 16.4 months (range, 8.3-22.0 months) without anti-CMV therapy. Human immunodeficiency viral load remained stable following cessation of anti-CMV medications. Blood and urine assays for CMV were briefly positive in 9 patients, but did not predict reactivation of CMV disease. Worsening immune recovery uveitis was associated with a substantial (&gt;3 lines) vision loss in 3 patients. Maintenance anti-CMV medications were safely stopped in those patients who had stable CMV retinitis and elevated CD4+ cell counts and who were taking HAART. It is concluded that immune recovery following potent antiretroviral therapy is effective in controlling a major opportunistic infection, even in patients with a history of severe immunosuppression.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - CD4+ lymphocytes
KW  - clinical aspects
KW  - disease course
KW  - drug therapy
KW  - follow up
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - immunocompromised hosts
KW  - morbidity
KW  - mortality
KW  - opportunistic infections
KW  - relapse
KW  - retinitis
KW  - uveitis
KW  - viral load
KW  - vision
KW  - Maryland
KW  - USA
KW  - Human herpesvirus 5
KW  - man
KW  - Cytomegalovirus
KW  - Betaherpesvirinae
KW  - Herpesviridae
KW  - dsDNA viruses
KW  - DNA viruses
KW  - viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - South Atlantic States of USA
KW  - Southern States of USA
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - AIDS
KW  - CD4+ cells
KW  - chemotherapy
KW  - clinical picture
KW  - death rate
KW  - disease progression
KW  - human cytomegalovirus
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - recurrence of disease
KW  - relapses
KW  - sight
KW  - T4 lymphocytes
KW  - United States of America
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004812&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.
AU  - George, K. M.
AU  - Chatterjee, D.
AU  - Gunawardana, G.
AU  - Welty, D.
AU  - Hayman, J.
AU  - Lee, R.
AU  - Small, P. L. C.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1999///
VL  - 283
IS  - 5403
SP  - 854
EP  - 857
SN  - 0036-8075
AD  - George, K. M.: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
N1  - Accession Number: 19992005112.  Publication Type: Journal Article.  Language: English.  Number of References: 25 ref.
N2  - M. ulcerans is the causative agent of Buruli ulcer, a severe human skin disease that occurs primarily in Africa and Australia. Infection with M. ulcerans results in persistent severe necrosis without an acute inflammatory response. The presence of histopathological changes distant from the site of infection suggested that pathogenesis might be toxin mediated. A polyketide-derived macrolide designated mycolactone was isolated that causes cytopathicity and cell cycle arrest in cultured L929 murine fibroblasts. Intradermal inoculation of purified toxin into guineapigs produced a lesion similar to that of Buruli ulcer in humans. This toxin may represent one of a family of virulence factors associated with pathology in mycobacterial diseases such as leprosy and tuberculosis.
KW  - bacterial toxins
KW  - cell cycle
KW  - cytopathogenicity
KW  - fibroblasts
KW  - histopathology
KW  - infections
KW  - leprosy
KW  - mycobacterial diseases
KW  - necrosis
KW  - pathogenesis
KW  - pathology
KW  - skin
KW  - skin diseases
KW  - toxins
KW  - tuberculosis
KW  - ulcers
KW  - virulence
KW  - Africa
KW  - Australia
KW  - guineapigs
KW  - man
KW  - Mycobacterium
KW  - Mycobacterium ulcerans
KW  - Cavia
KW  - Caviidae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - Mycobacteriaceae
KW  - Corynebacterineae
KW  - Actinomycetales
KW  - Actinobacteridae
KW  - Actinobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Mycobacterium
KW  - APEC countries
KW  - Australasia
KW  - Oceania
KW  - Commonwealth of Nations
KW  - Developed Countries
KW  - OECD Countries
KW  - bacterium
KW  - dermatoses
KW  - dermis
KW  - guinea pigs
KW  - mycobacterial infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005112&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
AU  - Carrington, M.
AU  - Nelson, G. W.
AU  - Martin, M. P.
AU  - Kissner, T.
AU  - Vlahov, D.
AU  - Goedert, J. J.
AU  - Kaslow, R.
AU  - Buchbinder, S.
AU  - Hoots, K.
AU  - O'Brien, S. J.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1999///
VL  - 283
IS  - 5408
SP  - 1748
EP  - 1752
SN  - 0036-8075
AD  - Carrington, M.: Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute (NCI), Frederick, MD 21702-1201, USA.
N1  - Accession Number: 19992003742.  Publication Type: Journal Article.  Language: English.  Number of References: 42 ref.
N2  - A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex (human leukocyte antigen (HLA) class I and class II) is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of class I loci (A, B and C) delayed acquired immunodeficiency syndrome (AIDS) onset among patients infected with human immunodeficiency virus-type 1 (HIV-1), whereas individuals who were homozygous for one or more loci progressed rapidly to AIDS and death. The HLA class I alleles B*35 and Cw*04 were consistently associated with rapid development of AIDS-defining conditions in Caucasians. The extended survival of 28-40% of HIV-1-infected Caucasian patients who avoided AIDS for 10 or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.
KW  - acquired immune deficiency syndrome
KW  - antigens
KW  - disease course
KW  - genes
KW  - heterozygosity
KW  - HIV-1 infections
KW  - homozygosity
KW  - human diseases
KW  - human leukocyte antigens
KW  - major histocompatibility complex
KW  - survival
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - antigenicity
KW  - disease progression
KW  - histocompatibility complex
KW  - human immunodeficiency virus type 1
KW  - immunogens
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003742&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
AU  - Schaeffer, E. M.
AU  - Debnath, J.
AU  - Yap, G.
AU  - McVicar, D.
AU  - Liao, X. C.
AU  - Littman, D. R.
AU  - Sher, A.
AU  - Varmus, H. E.
AU  - Lenardo, M. J.
AU  - Schwartzberg, P. L.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1999///
VL  - 284
IS  - 5414
SP  - 638
EP  - 641
SN  - 0036-8075
AD  - Schaeffer, E. M.: National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
N1  - Accession Number: 19990804719.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 60-18-4.  Subject Subsets: Protozoology
N2  - Combined deletion in mice of 2 Tec kinases, Rlk and Itk, caused marked defects in T cell receptor (TCR) responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo. Molecular events immediately downstream from the TCR were intact in rlk-/-itk-/- cells, but intermediate events including inositol trisphosphate production, calcium mobilization, and mitogen-activated protein kinase activation were impaired, establishing Tec kinases as critical regulators of TCR signalling required for phospholipase C-γ activation.
KW  - apoptosis
KW  - cytokines
KW  - experimental infections
KW  - immune response
KW  - immunity
KW  - in vitro
KW  - kinases
KW  - laboratory animals
KW  - parasites
KW  - receptors
KW  - T lymphocytes
KW  - tyrosine
KW  - mice
KW  - protozoa
KW  - Toxoplasma gondii
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - invertebrates
KW  - Toxoplasma
KW  - Sarcocystidae
KW  - Eucoccidiorida
KW  - Apicomplexa
KW  - Protozoa
KW  - immunity reactions
KW  - immunological reactions
KW  - T cells
KW  - Host Resistance and Immunity (HH600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum.
AU  - Su XinZhuan
AU  - Ferdig, M. T.
AU  - Huang YaMing
AU  - Huynh, C. Q.
AU  - Liu, A.
AU  - You JingTao
AU  - Wootton, J. C.
AU  - Wellems, T. E.
JO  - Science (Washington)
JF  - Science (Washington)
Y1  - 1999///
VL  - 286
IS  - 5443
SP  - 1351
EP  - 1353
SN  - 0036-8075
AD  - Su XinZhuan: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000804821.  Publication Type: Journal Article.  Language: English.  Number of References: 18 ref. Subject Subsets: Protozoology
N2  - Genetic investigations of malaria require a genome-wide, high-resolution linkage map of Plasmodium falciparum. A genetic cross is reported that was used to construct such a map from 901 markers that fall into 14 inferred linkage groups corresponding to the 14 nuclear chromosomes. Meiotic crossover activity in the genome proved high (17 kilobases per centimorgan) and notably uniform over chromosome length. Gene conversion events and spontaneous microsatellite length changes were evident in the inheritance data. The markers, map and recombination parameters are facilitating genome sequence assembly, localization of determinants for such traits as virulence and drug resistance, and genetic studies of parasite field populations.
KW  - chromosomes
KW  - drug resistance
KW  - gene mapping
KW  - genes
KW  - genetic markers
KW  - genetics
KW  - genomes
KW  - linkage
KW  - meiosis
KW  - microsatellites
KW  - molecular genetics
KW  - parasites
KW  - population genetics
KW  - recombination
KW  - virulence
KW  - Plasmodium falciparum
KW  - protozoa
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - biochemical genetics
KW  - genetic recombination
KW  - minisatellites
KW  - reduction division
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Animal Genetics (LL220) (Discontinued March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804821&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Construction of modular and versatile plasmid vectors for the high-level expression of single or multiple genes in insects and insect cell lines.
AU  - Huynh, C. Q.
AU  - Zieler, H.
JO  - Journal of Molecular Biology
JF  - Journal of Molecular Biology
Y1  - 1999///
VL  - 288
IS  - 1
SP  - 13
EP  - 20
SN  - 0022-2836
AD  - Huynh, C. Q.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
N1  - Accession Number: 20000506676.  Publication Type: Journal Article.  Language: English.  Number of References: 70 ref. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology
N2  - A series of plasmid vectors for the expression of foreign genes in insects or insect cell lines was constructed and tested using Aedes albopictus C6/36 cells and Anopheles gambiae embryos.
KW  - cell lines
KW  - gene expression
KW  - genes
KW  - genetic engineering
KW  - genetic vectors
KW  - genetically engineered organisms
KW  - molecular genetics
KW  - transgenic animals
KW  - Aedes albopictus
KW  - Anopheles gambiae
KW  - Culicidae
KW  - Diptera
KW  - Aedes
KW  - Culicidae
KW  - Diptera
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Anopheles
KW  - Asian tiger mosquito
KW  - biochemical genetics
KW  - cloning vectors
KW  - genetic manipulation
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GEOs
KW  - GMOs
KW  - mosquitoes
KW  - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW  - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW  - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Studies on vaccines against cholera. Synthesis of neoglycoconjugates from the hexasaccharide determinant of Vibrio cholerae O:1, serotype Ogawa, by single-point attachment or by attachment of the hapten in the form of clusters.
AU  - Zhang Jian
AU  - Kováč, P.
JO  - Carbohydrate Research
JF  - Carbohydrate Research
Y1  - 1999///
VL  - 321
IS  - 3/4
SP  - 157
EP  - 167
SN  - 0008-6215
AD  - Zhang Jian: National Institutes of Health, NIDDK, Laboratory of Medicinal Chemistry, 8 Center Drive, Bethesda, MD 20892-0815, USA.
N1  - Accession Number: 20002016394.  Publication Type: Journal Article.  Language: English.  Number of References: 38 ref. Subject Subsets: Tropical Diseases
N2  - The terminal hexasaccharide of the O-antigen of Vibrio cholerae O:1, serotype Ogawa, has been synthesized in the form of a glycoside whose aglycon (linker) allows conjugation to carrier proteins by reductive amination. The conjugate obtained from direct, single-point attachment of the linker-equipped hapten to chicken serum albumin (CSA) contained seven hapten residues/CSA. A neoglycoconjugate containing the carbohydrate antigen in the form of clusters was obtained using, as a hapten subcarrier, an oligopeptide containing 16 amino groups. It was treated with a limited amount of hapten, to give a hapten-carrying subcarrier (HCS). Subsequent conjugation of HCS to CSA, using squaric acid diethyl ester as a conjugation reagent, gave a cross-linked, glycocluster conjugate containing 51% (w/w) of the carbohydrate.
KW  - albumins
KW  - antigens
KW  - binding proteins
KW  - carbohydrates
KW  - human diseases
KW  - proteins
KW  - serotypes
KW  - vaccines
KW  - man
KW  - Vibrio cholerae
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Vibrio
KW  - Vibrionaceae
KW  - Vibrionales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - antigenicity
KW  - bacterium
KW  - carrier proteins
KW  - immunogens
KW  - saccharides
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Host Resistance and Immunity (HH600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002016394&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.
AU  - Ciolino, H. P.
AU  - Daschner, P. J.
AU  - Yeh, G. C.
JO  - Biochemical Journal (London)
JF  - Biochemical Journal (London)
Y1  - 1999///
VL  - 340
IS  - 3
SP  - 715
EP  - 722
SN  - 0264-6021
AD  - Ciolino, H. P.: Cellular Defense and Carcinogenesis Section, Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, National Institutes of Health, Building 560, Room 12-05, P. O. Box B, Frederick, MD, 21702-1201, USA.
N1  - Accession Number: 19991410276.  Publication Type: Journal Article.  Language: English.  Number of References: 46 ref. Registry Number: 9035-51-2, 520-18-3, 117-39-5.  Subject Subsets: Human Nutrition
N2  - Transcriptional activation of the human CYP1A1 gene (coding for cytochrome P-450 1A1) is mediated by the aryl hydrocarbon receptor (AhR). In the present study the effect of the common dietary polyphenolic compounds quercetin and kaempferol on the transcription of CYP1A1 and the function of the AhR in MCF-7 was investigated in human breast cancer cells. Quercetin caused a time- and concentration-dependent increase in the amount of CYP1A1 mRNA and CYP1A1 enzyme activity in MCF-7 cells. The increase in CYP1A1 mRNA caused by quercetin was prevented by the transcription inhibitor actinomycin D. Quercetin also caused an increase in the transcription of a chloramphenicol reporter vector containing the CYP1A1 promoter. Quercetin failed to induce CYP1A1 enzyme activity in AhR-deficient MCF-7 cells. Gel retardation studies demonstrated that quercetin activated the ability of the AhR to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the CYP1A1 promoter. These results indicate that quercetin's effect is mediated by the AhR. Kaempferol did not affect CYP1A1 expression by itself but it inhibited the transcription of CYP1A1 induced by the prototypical AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as measured by a decrease in TCDD-induced CYP1A1 promoter-driven reporter vector activity, and CYP1A1 mRNA in cells. Kaempferol also abolished TCDD-induced XRE binding in a gel-shift assay. Both compounds were able to compete with TCDD for binding to a cytosolic extract of MCF-7 cells. Known ligands of the AhR are, for the most part, man-made compounds such as halogenated and polycyclic aromatic hydrocarbons. These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription.
KW  - breast cancer
KW  - cell cultures
KW  - cytochrome P-450
KW  - flavonols
KW  - gene expression
KW  - kaempferol
KW  - mammary gland neoplasms
KW  - neoplasms
KW  - polyphenols
KW  - quercetin
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - cancers
KW  - mammary tumour
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Physiology of Human Nutrition (VV120) 
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ER  - 

TY  - JOUR
T1  - Hyper-IgE syndrome with recurrent infections - an autosomal dominant multisystem disorder.
AU  - Grimbacher, B.
AU  - Holland, S. M.
AU  - Gallin, J. I.
AU  - Greenberg, F.
AU  - Hill, S. C.
AU  - Malech, H. L.
AU  - Miller, J. A.
AU  - O'Connell, A. C.
AU  - Puck, J. M.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999///
VL  - 340
IS  - 9
SP  - 692
EP  - 702
SN  - 0028-4793
AD  - Grimbacher, B.: Genetics and Molecular Biology Branch, National Institutes of Health, Bethesda, MD, USA.
N1  - Accession Number: 19992003269.  Publication Type: Journal Article.  Language: English.  Number of References: 62 ref.
N2  - The hyper-IgE syndrome with recurrent infections is a rare immunodeficiency characterized by recurrent skin and pulmonary abscesses and extremely elevated levels of IgE in serum. Associated facial and skeletal features have been recognized, but their frequency is unknown, and the genetic basis of the hyper-IgE syndrome is poorly understood. 30 patients with the hyper-IgE syndrome and 70 of their relatives were studied. The authors took histories, reviewed records, performed physical and dental examinations, took anthropometric measurements, and conducted laboratory studies. Nonimmunologic features of the hyperIgE syndrome were present in all patients older than 8 years. 72% had the previously unrecognized feature of failure or delay of shedding of the primary teeth owing to lack of root resorption. Common findings among patients were recurrent fractures (in 57% of patients), hyperextensible joints (in 68%), and scoliosis (in 76% of patients 16 years of age or older). The classic triad of abscesses, pneumonia, and an elevated IgE level was identified in 77% of all patients and in 85% of those older than 8. In 6 of 23 adults (26%), IgE levels declined over time and came closer to or fell within the normal range. Autosomal dominant transmission of the hyper-IgE syndrome was found, but with variable expressivity. Of the 27 relatives at risk for inheriting the hyper-IgE syndrome, 10 were fully affected, 11 were unaffected, and 6 had combinations of mild immunologic, dental, and skeletal features of the hyper-IgE syndrome. The hyper-IgE syndrome is a multisystem disorder that affects the dentition, the skeleton, connective tissue, and the immune system. It is inherited as a single-locus autosomal dominant trait with variable expressivity.
KW  - clinical aspects
KW  - hereditary diseases
KW  - human diseases
KW  - symptoms
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - clinical picture
KW  - hyper-IgE syndrome
KW  - Non-communicable Human Diseases and Injuries (VV600) 
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ER  - 

TY  - JOUR
T1  - Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia.
AU  - Walsh, T. J.
AU  - Finberg, R. W.
AU  - Arndt, C.
AU  - Hiemenz, J.
AU  - Schwartz, C.
AU  - Bodensteiner, D.
AU  - Pappas, P.
AU  - Seibel, N.
AU  - Greenberg, R. N.
AU  - Dummer, S.
AU  - Schuster, M.
AU  - Holcenberg, J. S.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999///
VL  - 340
IS  - 10
SP  - 764
EP  - 771
SN  - 0028-4793
AD  - Walsh, T. J.: National Cancer Institute, Bethesda, MD 20892, USA.
N1  - Accession Number: 19991200962.  Publication Type: Journal Article.  Language: English.  Number of References: 30 ref. Registry Number: 1397-89-3.  Subject Subsets: Medical & Veterinary Mycology
N2  - A randomized, double-blind, multicentre trial comparing liposomal amphotericin B with conventional amphotericin B as empirical antifungal therapy was conducted in the USA. The mean duration of therapy was 10.8 days for liposomal amphotericin B (343 patients) and 10.3 days for conventional amphotericin B (344 patients). The composite rates of successful treatment were similar (50% for liposomal amphotericin B and 49% for conventional amphotericin B) and were independent of the use of antifungal prophylaxis or colony-stimulating factors. The outcomes were similar with liposomal amphotericin B and conventional amphotericin B with respect to survival (93% and 90%, respectively), resolution of fever (58% and 58%) and discontinuation of the study drug because of toxic effects or lack of efficacy (14% and 19%). There were fewer proved breakthrough fungal infections among patients treated with liposomal amphotericin B (11 patients, 3.2%) than among those treated with conventional amphotericin B (27 patients, 7.8%, P=0.009). Fungal infections were due to Aspergillus, Candida and Fusarium, and 1 episode of zygomycosis. With the liposomal preparation significantly fewer patients had infusion-related fever (17% vs. 44%), chills or rigors (18% vs. 54%) and other reactions, including hypotension, hypertension and hypoxia. Nephrotoxic effects (defined by a serum creatinine level 2-fold the upper limit of normal) were significantly less frequent among patients treated with liposomal amphotericin B (19%) than among those treated with conventional amphotericin B (34%, P&lt;0.001). Liposomal amphotericin B is as effective as conventional amphotericin B for empirical antifungal therapy in patients with fever and neutropenia, and it is associated with fewer breakthrough fungal infections, less infusion-related toxicity, and less nephrotoxicity.
KW  - amphotericin B
KW  - antifungal agents
KW  - application methods
KW  - clinical trials
KW  - colony stimulating factor
KW  - drug formulations
KW  - drug therapy
KW  - drug toxicity
KW  - efficacy
KW  - human diseases
KW  - immunocompromised hosts
KW  - infections
KW  - liposomes
KW  - mycoses
KW  - nephrotoxicity
KW  - opportunistic infections
KW  - predisposition
KW  - prophylaxis
KW  - zygomycosis
KW  - USA
KW  - Aspergillus
KW  - Candida
KW  - fungi
KW  - Fusarium
KW  - man
KW  - Trichocomaceae
KW  - Eurotiales
KW  - Eurotiomycetes
KW  - Pezizomycotina
KW  - Ascomycota
KW  - fungi
KW  - eukaryotes
KW  - Saccharomycetales
KW  - Saccharomycetes
KW  - Saccharomycotina
KW  - Nectriaceae
KW  - Hypocreales
KW  - Sordariomycetes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - chemotherapy
KW  - fungistats
KW  - fungus
KW  - Hyphomycetes
KW  - phycomycosis
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1. A meta-analysis of 15 prospective cohort studies.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999///
VL  - 340
IS  - 13
SP  - 977
EP  - 987
SN  - 0028-4793
AD  - Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Executive Bldg., Rm. 4B11F, 6100 Executive Blvd. MSC 7510, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 19992006532.  Publication Type: Journal Article.  Corporate Author: International Perinatal HIV Group Language: English.  Number of References: 53 ref. Subject Subsets: Public Health
N2  - To evaluate the relation between elective caesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), North American and European studies of ≥100 mother-child pairs were included in the meta-analysis. Elective caesarean sections were defined as those performed before onset of labour and rupture of membranes. The primary analysis included data on 8533 mother-child pairs. After adjustment for receipt of antiretroviral therapy, maternal stage of disease and infant birth weight, the likelihood of vertical transmission of HIV-1 was decreased by approx. 50% with elective caesarean section, as compared with other modes of delivery (adjusted odds ratio (AOR) 0.43; 95% confidence interval (CI) 0.33-0.56). The results were similar when the study population was limited to those with rupture of membranes shortly before delivery. The likelihood of transmission was reduced by approx. 87% with both elective caesarean section and receipt of antiretroviral therapy during the prenatal, intrapartum and neonatal periods, as compared with other modes of delivery and the absence of therapy (AOR 0.13; 95% CI 0.09-0.19). Among mother-child pairs receiving antiretroviral therapy during the prenatal, intrapartum and neonatal periods, rates of vertical transmission were 2.0% among the 196 mothers who underwent elective caesarean section and 7.3% among the 1255 mothers with other modes of delivery.
KW  - caesarean section
KW  - childbirth
KW  - disease prevention
KW  - human diseases
KW  - maternal transmission
KW  - neonates
KW  - pregnancy
KW  - risk factors
KW  - vertical transmission
KW  - viral diseases
KW  - women
KW  - Europe
KW  - North America
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - America
KW  - gestation
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - newborn infants
KW  - viral infections
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
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TY  - JOUR
T1  - A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy.
AU  - Freifeld, A.
AU  - Marchigiani, D.
AU  - Walsh, T.
AU  - Chanock, S.
AU  - Lewis, L.
AU  - Hiemenz, J.
AU  - Hiemenz, S.
AU  - Hicks, J. E.
AU  - Gill, V.
AU  - Steinberg, S. M.
AU  - Pizzo, P. A.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999///
VL  - 341
IS  - 5
SP  - 305
EP  - 311
SN  - 0028-4793
AD  - Freifeld, A.: National Cancer Institute, National Institutes of Health Bethesda, Maryland, USA.
N1  - Accession Number: 19992011830.  Publication Type: Journal Article.  Language: English.  Number of References: 23 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 72558-82-8, 85721-33-1. 
N2  - A randomized, doubleblind, placebo-controlled study of patients (5 to 74 years of age) who had fever and neutropenia during chemotherapy for cancer was conducted during May 1992 to July 1997 in the USA. Neutropenia was expected to be present for no more than 10 days in these patients, and they had to have no other underlying conditions. Patients were assigned to receive either oral ciprofloxacin plus amoxicillin-clavulanate or intravenous ceftazidime. They were hospitalized until fever and neutropenia resolved. 116 episodes were included in each group (84 patients in the oral-therapy group and 79 patients in the intravenous-therapy group). The mean neutrophil counts at admission were 81 per cubic millimeter and 84 per cubic millimeter, respectively; the mean duration of neutropenia was 3.4 and 3.8 days, respectively. Treatment was successful without the need for modifications in 71% of episodes in the oral-therapy group and 67% of episodes in the intravenous-therapy group (difference between groups, 3%; 95% confidence interval, -8% to 15%; P=0.48). Treatment was considered to have failed because of the need for modifications in the regimen in 13% and 32% of episodes, respectively (P&lt;0.001) and because of the patient's inability to tolerate the regimen in 16% and 1% of episodes, respectively (P&lt;0.001). There were no deaths. The incidence of intolerance of the oral antibiotics was 16% compared with 8% for placebo (P=0.07). It is concluded that in hospitalized low-risk patients who have fever and neutropenia during cancer chemotherapy, empirical therapy with oral ciprofloxacin and amoxicillin-clavulanate is safe and effective.
KW  - amoxicillin
KW  - antibiotics
KW  - bacterial diseases
KW  - ceftazidime
KW  - ciprofloxacin
KW  - drug therapy
KW  - fever
KW  - human diseases
KW  - immunocompromised hosts
KW  - neutropenia
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - amoxycillin
KW  - bacterial infections
KW  - bacterioses
KW  - bacterium
KW  - chemotherapy
KW  - pyrexia
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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ER  - 

TY  - JOUR
T1  - Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine.
AU  - Mofenson, L. M.
AU  - Lambert, J. S.
AU  - Stiehm, E. R.
AU  - Bethel, J.
AU  - Meyer, W. A., III
AU  - Whitehouse, J.
AU  - Moye, J., Jr.
AU  - Reichelderfer, P.
AU  - Harris, D. R.
AU  - Fowler, M. G.
AU  - Mathieson, B. J.
AU  - Nemo, G. J.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999///
VL  - 341
IS  - 6
SP  - 385
EP  - 393
SN  - 0028-4793
AD  - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, National Institutes of Health, Bethesda, Maryland, USA.
N1  - Accession Number: 19992010562.  Publication Type: Journal Article.  Corporate Author: USA, Pediatric AIDS Clinical Trials Group Study 185 Team Language: English.  Number of References: 43 ref. Registry Number: 30516-87-1.  Subject Subsets: Public Health; Tropical Diseases
N2  - The effects were investigated of maternal, obstetrical and infant-related characteristics and maternal virological and immunological variables on the risk of perinatal transmission of HIV-1 among 480 women and their infants, all of whom received zidovudine. The women and infants were participating in a phase 3 trial of passive immunoprophylaxis for the prevention of perinatal transmission, conducted between October 1993 and March 1997 at 53 clinical sites in USA and Puerto Rico. In univariate analyses, the risk of perinatal transmission was associated with each of the following: decreased maternal CD4+ lymphocyte counts at base line; decreased maternal HIV-1 p24 antibody levels at base line and delivery; increased maternal HIV-1 titre at base line and delivery; increased maternal HIV-1 RNA levels at base line and delivery; and the presence of chorioamnionitis at delivery. In multivariate analyses, the only independent risk factor was the maternal HIV-1 RNA level at base line (odds ratio for transmission, 2.4 per log increase in the number of copies; 95 percent confidence interval, 1.2 to 4.7; P=0.02) and at delivery (odds ratio, 3.4; 95% confidence interval, 1.7 to 6.8; P=0.001). There was no perinatal transmission of HIV-1 among the 84 women who had HIV-1 levels below the limit of detection (500 copies per ml) at base line or the 107 women who had undetectable levels at delivery. Among pregnant women and their infants, all treated with zidovudine, the maternal plasma HIV-1 RNA level was the best predictor of the risk of perinatal transmission of HIV-1. It is concluded that antiretroviral therapy that reduces the HIV-1 RNA level to below 500 copies per ml appears to minimize the risk of perinatal transmission as well as improve the health of the women.
KW  - disease transmission
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - maternal transmission
KW  - neonates
KW  - pregnancy
KW  - prophylaxis
KW  - risk factors
KW  - women
KW  - zidovudine
KW  - Puerto Rico
KW  - USA
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developing Countries
KW  - Greater Antilles
KW  - Antilles
KW  - Caribbean
KW  - America
KW  - Latin America
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - OECD Countries
KW  - AZT
KW  - chemotherapy
KW  - gestation
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - newborn infants
KW  - Porto Rico
KW  - United States of America
KW  - Pesticides and Drugs (General) (HH400) 
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Human Reproduction and Development (VV060) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - The AIDS epidemic considerations for the 21st century.
AU  - Fauci, A. S.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999///
VL  - 341
IS  - 14
SP  - 1046
EP  - 1050
SN  - 0028-4793
AD  - Fauci, A. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20002005354.  Publication Type: Journal Article.  Language: English.  Number of References: 48 ref. Subject Subsets: Public Health
N2  - The origins of human immunodeficiency virus, the scope of the epidemic, the successes and limitations of antiretroviral therapy, prevention of HIV infection, and development of an HIV vaccine are discussed.
KW  - acquired immune deficiency syndrome
KW  - drug therapy
KW  - epidemics
KW  - epidemiology
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - prevention
KW  - reviews
KW  - vaccine development
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Therapeutic vaccines for preventing AIDS: their use with HAART.
AU  - Hoff, R.
AU  - McNamara, J.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1999///
VL  - 353
IS  - 9166
SP  - 1723
EP  - 1724
SN  - 0140-6736
AD  - Hoff, R.: Vaccine and Prevention Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
N1  - Accession Number: 20002006608.  Publication Type: Journal Article.  Language: English.  Number of References: 14 ref. Subject Subsets: Public Health
N2  - A commentary on the studies conducted by Sandström, E., et al. (The Lancet (1999) 353, 1735-1742), Rosenberg, E.S., et al. (Science, (1997) 278, 1447-1450) and Valentine, F.T., et al. (Conference Supplement 12th World AIDS Conference, Geneva, Switzerland, between 28 June and 3 July 1998) on the use of immunotherapy in human immunodeficiency virus type 1 (HIV-1) infections is presented.
KW  - acquired immune deficiency syndrome
KW  - antiviral agents
KW  - disease prevention
KW  - drug therapy
KW  - HIV-1 infections
KW  - human diseases
KW  - immunization
KW  - immunotherapy
KW  - vaccines
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - AIDS
KW  - chemotherapy
KW  - human immunodeficiency virus type 1
KW  - immune sensitization
KW  - Pesticides and Drugs; Control (HH405) (New March 2000)
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW  - Host Resistance and Immunity (HH600) 
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DB  - lhh
ER  - 

TY  - JOUR
T1  - Human T-lymphotropic virus type I infection.
AU  - Manns, A.
AU  - Hisada, M.
AU  - Grenade, L. la
AU  - la Grenade, L.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1999///
VL  - 353
IS  - 9168
SP  - 1951
EP  - 1958
SN  - 0140-6736
AD  - Manns, A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
N1  - Accession Number: 19992008855.  Publication Type: Journal Article.  Language: English.  Number of References: 82 ref. Subject Subsets: Tropical Diseases; Public Health
N2  - Human T-cell lymphotropic virus type I (HTLV-I) is the first human retrovirus to be associated with malignant disease-namely, adult T-cell leukaemia/lymphoma. HTLV-I has also been associated with several non-malignant conditions, notably the chronic neurodegenerative disorder, HTLV-I associated myelopathy (also known as tropical spastic paraparesis), infective dermatitis of children and uveitis. More recent evidence points to disease associations not previously linked to HTLV-I. Thus, the disease spectrum of HTLV-I is not fully known. HTLV-I has a worldwide distribution with major endemic foci in the Caribbean and southern Japan. The public health importance is confirmed by the major routes of transmission, which are mother-to-child, blood transfusion, and sexual activity. Unfortunately, no vaccine is available yet and there is no proven treatment for advanced HTLV-I disease.
KW  - dermatitis
KW  - disease transmission
KW  - epidemiology
KW  - HTLV infections
KW  - human diseases
KW  - leukaemia
KW  - lymphoma
KW  - myelopathy
KW  - reviews
KW  - tropical spastic paraparesis
KW  - uveitis
KW  - Deltaretrovirus
KW  - human T-cell lymphotropic virus
KW  - man
KW  - Deltaretrovirus
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - blood cancer
KW  - HTLV-BLV group
KW  - human T lymphotropic virus infections
KW  - human T-cell leukaemia virus infections
KW  - human T-cell lymphotropic virus infections
KW  - leucaemia
KW  - leukemia
KW  - neurodegenerative disorder
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood.
AU  - Perlmutter, S. J.
AU  - Leitman, S. F.
AU  - Garvey, M. A.
AU  - Hamburger, S.
AU  - Feldman, E.
AU  - Leonard, H. L.
AU  - Swedo, S. E.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1999///
VL  - 354
IS  - 9185
SP  - 1153
EP  - 1158
SN  - 0140-6736
AD  - Perlmutter, S. J.: Pediatrics and Developmental Neuropsychiatry Branch, National Institutes of Health, Bethesda, MD 20892, USA.
N1  - Accession Number: 20002006972.  Publication Type: Journal Article.  Language: English.  Number of References: 29 ref. Registry Number: 308067-57-4. 
N2  - It was studied in the USA whether plasma exchange or intravenous immunoglobulin (IVIG) would be better than placebo (sham IVIG) in reducing severity of neuropsychiatric symptoms following infection with group A β-haemolytic streptococci. Children with severe, infection-triggered exacerbations of obsessive-compulsive disorder (OCD) or tic disorders, including Tourette syndrome, were randomly assigned treatment with plasma exchange (5 single-volume exchanges over 2 weeks), IVIG (1 g/kg daily on 2 consecutive days), or placebo (saline solution given in the same manner as IVIG). Symptom severity was rated at baseline, and at 1 month and 12 months after treatment by use of standard assessment scales for OCD, tics, anxiety, depression, and global function. 30 children entered the study and 29 completed the trial. Ten received plasma exchange, 9 IVIG, and 10 placebo. At 1 month, the IVIG and plasma-exchange groups showed striking improvements in obsessive-compulsive symptoms (mean improvement on children's Yale-Brown obsessive compulsive scale score of 12 (45%) and 13 (58%), respectively), anxiety (2.1 (31%) and 3.0 (47%) improvement on National Institute of Mental Health anxiety scale), and overall functioning (2.9 (33%) and 2.8 (35%) improvement on National Institute of Mental Health global scale). Tic symptoms were also significantly improved by plasma exchange (mean change on Tourette syndrome unified rating scale of 49%). Treatment gains were maintained at 1 year, with 14 (82%) of 17 children "much" or "very much" improved over baseline (7 of 8 for plasma exchange, 7 of 9 for IVIG). Plasma exchange and IVIG were both effective in lessening of symptom severity for children with infection-triggered OCD and tic disorders.
KW  - autoimmunity
KW  - blood plasma
KW  - children
KW  - human diseases
KW  - immunoglobulins
KW  - intravenous injection
KW  - nervous system diseases
KW  - USA
KW  - man
KW  - Streptococcaceae
KW  - Streptococcus
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Lactobacillales
KW  - Bacilli
KW  - Firmicutes
KW  - Bacteria
KW  - prokaryotes
KW  - Streptococcaceae
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - bacterium
KW  - beta-haemolytic streptococci
KW  - gamma-globulins
KW  - immune globulins
KW  - neuropathy
KW  - neuropsychiatry
KW  - plasma (blood)
KW  - post-streptococcal glomerulonephritis
KW  - United States of America
KW  - Host Resistance and Immunity (HH600) 
KW  - Non-communicable Human Diseases and Injuries (VV600) 
KW  - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW  - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Paediatric HIV-1 infection.
AU  - Burns, D. N.
AU  - Mofenson, L. M.
JO  - Lancet (British edition)
JF  - Lancet (British edition)
Y1  - 1999///
VL  - 354
IS  - Suppl. 2
SP  - 1
EP  - 6
SN  - 0140-6736
AD  - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510, USA.
N1  - Accession Number: 20002005568.  Publication Type: Journal Article.  Language: English.  Number of References: 60 ref.
KW  - antiviral agents
KW  - children
KW  - disease transmission
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - maternal transmission
KW  - pathogenesis
KW  - prophylaxis
KW  - Human immunodeficiency virus 1
KW  - man
KW  - human immunodeficiency viruses
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus infections
KW  - human immunodeficiency virus type 1
KW  - mother to child transmission
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Re-emergence of HIV after stopping therapy.
AU  - Chun TaeWook
AU  - Davey, R. T., Jr.
AU  - Engel, D.
AU  - Lane, H. C.
AU  - Fauci, A. S.
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1999///
VL  - 401
IS  - 6756
SP  - 874
EP  - 875
SN  - 0028-0836
AD  - Chun TaeWook: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20002004819.  Publication Type: Journal Article.  Language: English.  Number of References: 10 ref. Subject Subsets: Public Health
KW  - antiviral agents
KW  - drug therapy
KW  - HIV infections
KW  - human diseases
KW  - human immunodeficiency viruses
KW  - viraemia
KW  - man
KW  - Lentivirus
KW  - Orthoretrovirinae
KW  - Retroviridae
KW  - RNA Reverse Transcribing Viruses
KW  - viruses
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - chemotherapy
KW  - human immunodeficiency virus
KW  - human immunodeficiency virus infections
KW  - viremia
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW  - Pesticides and Drugs (General) (HH400) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Effect of Siamese cassia leaves on the activities of chemical carcinogen metabolizing enzymes and on mammary gland carcinogenesis in the rat.
AU  - Tepsuwan, A.
AU  - Kupradinun, P.
AU  - Kusamran, W. R.
JO  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF  - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1  - 1999///
VL  - 428
IS  - 1/2
SP  - 363
EP  - 373
SN  - 0027-5107
AD  - Tepsuwan, A.: Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand.
N1  - Accession Number: 20001418143.  Publication Type: Journal Article.  Language: English.  Number of References: 57 ref. Registry Number: 9035-51-2.  Subject Subsets: Dairy Science; Human Nutrition; Agroforestry
N2  - Male Wistar rats were fed AIN-76 semipurified diet or diet containing 5% ground lyophilized Siamese cassia (Cassia siamea) leaves for 2 weeks before sacrifice. Hepatic S9 fractions were prepared and assayed for the level of cytochrome P450 (P450), the activities of monooxygenase, i.e., aniline hydroxylase (ANH), aminopyrine-N-demethylase (AMD) as well as the capacity to metabolically activate the mutagenicities of aflatoxin B1 (AFB1) and benzo(a)pyrene (B(a)P). In addition, the activities of detoxificating enzymes such as glutathione-S-transferase (GST) and UDP-glucuronyltransferase (UGT) were also measured. It was found that feeding of Siamese cassia leaves significantly reduced the activities of hepatic ANH and AMD as well as the capacity to activate the mutagenicity of AFB1 towards Salmonella typhimurium TA100, being 31, 73 and 41% of control group, respectively. It also slightly decreased, but not significantly, the capacity to activate the mutagenicity of B(a)P towards S. typhimurium YG1029. On the other hand, however, the activities of both GST and UGT were markedly increased in those animals, being 250 and 220% of control animals. The anticarcinogenic potential of Siamese cassia leaves was also investigated in female Sprague Dawley rats treated with 9.10-dimethyl-1.2-benzanthracene (DMBA). The animals were fed control diet or diet containing ground lyophilized Siamese cassia leaves 2 weeks prior to and 1 week after intragastrically administration of DMBA, and then they were placed on a pellet diet for additional 25 weeks. Interestingly, it was found that feeding of diet containing 2.5 and 4% Siamese cassia leaves resulted in a significant decrease in the multiplicity of mammary gland tumors as well as a slight delay of the onset of tumor development. The incidence of tumors in the group fed 4% Siamese cassia leaves, but not in the 2.5% group, was lowered, although not significantly, than that of control group. The results in the present study therefore demonstrated that Siamese cassia leaves possess phase II enzyme inducing property as well as the ability to reduce some phase I enzyme activities in rat liver. This Thai vegetable also exhibit cancer chemopreventive potential, at least against DMBA-induced mammary gland carcinogenesis which may be partly due to phase II inducing capacity as well as phase I inhibitory activity.
KW  - aflatoxins
KW  - animal models
KW  - carcinogenesis
KW  - cytochrome P-450
KW  - diets
KW  - enzyme activity
KW  - feeding
KW  - inhibition
KW  - liver
KW  - mammary glands
KW  - mycotoxins
KW  - neoplasms
KW  - Thailand
KW  - Cassia
KW  - rats
KW  - Salmonella
KW  - Salmonella typhimurium
KW  - Senna siamea
KW  - Caesalpinioideae
KW  - Fabaceae
KW  - Fabales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - Enterobacteriaceae
KW  - Enterobacteriales
KW  - Gammaproteobacteria
KW  - Proteobacteria
KW  - Bacteria
KW  - prokaryotes
KW  - Salmonella enterica subsp. enterica
KW  - Salmonella enterica
KW  - Salmonella
KW  - Senna (genus)
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - bacterium
KW  - cancers
KW  - fungal toxins
KW  - leave
KW  - Animal Models of Human Nutrition (VV140) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Progress in cancer chemoprevention.
AU  - Kelloff, G. J.
AU  - Crowell, J. A.
AU  - Steele, V. E.
AU  - Lubet, R. A.
AU  - Boone, C. W.
AU  - Malone, W. A.
AU  - Hawk, E. T.
AU  - Lieberman, R.
AU  - Lawrence, J. A.
AU  - Kopelovich, L.
AU  - Iqbal Ali
AU  - Viner, J. L.
AU  - Sigman, C. C.
A2  - Bradlow, H. L.
A2  - Fishman, J.
A2  - Osborne, M. P.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1999///
VL  - 889
SP  - 1
EP  - 13
CY  - New York; USA
PB  - New York Academy of Sciences
SN  - 0077-8923
SN  - 1573311987\1573311995
AD  - Kelloff, G. J.: National Cancer Institute, Division of Cancer Prevention, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20013018040.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 38 ref. Registry Number: 7440-70-2, 7782-49-2, 1406-18-4.  Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2  - More than 40 promising agents and agent combinations are being evaluated clinically as chemopreventive drugs for major cancer targets. A few have been in vanguard, large-scale intervention trials - for example, the studies of tamoxifen and fenretinide in breast, 13-cis-retinoic acid in head and neck, vitamin E and selenium in prostate, and calcium in colon. These and other agents are currently in phase II chemoprevention trials to establish the scope of their chemopreventive efficacy and to develop intermediate biomarkers as surrogate end points for cancer incidence in future studies. In this group are fenretinide, 2-difluoromethylornithine, and oltipraz. Nonsteroidal anti-inflammatories (NSAID) are also in this group because of their colon cancer chemopreventive effects in clinical intervention, epidemiological, and animal studies. New agents are continually considered for development as chemopreventive drugs. Preventive strategies with antiandrogens are evolving for prostate cancer. Anti-inflammatories that selectively inhibit inducible cyclooxygenase (COX)-2 are being investigated in colon as alternatives to the NSAID, which inhibit both COX-1 and COX-2 and derive their toxicity from COX-1 inhibition. Newer retinoids with reduced toxicity, increased efficacy, or both (e.g., 9-cis-retinoic aclecular) and genomic biomarkers that can be used for risk assessment and as surrogate end points in clinical studies, (2) animal carcinogenesis models that mimic human disease (including transgenic and gene knockout mice), and (3) novel agent treatment regimens (e.g., local delivery to cancer targets, agent combinations, and pharmacodynamically guided dosing).
KW  - calcium
KW  - carcinogenesis
KW  - colon
KW  - epidemiology
KW  - genetically engineered organisms
KW  - human diseases
KW  - inhibition
KW  - models
KW  - neoplasms
KW  - prevention
KW  - prostate
KW  - retinoids
KW  - selenium
KW  - toxicity
KW  - transgenic animals
KW  - vitamin E
KW  - man
KW  - mice
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Muridae
KW  - rodents
KW  - cancers
KW  - genetically engineered animals
KW  - genetically modified animals
KW  - genetically modified organisms
KW  - GEOs
KW  - GMOs
KW  - vitamin A compounds
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Season-specific correlation between dietary intake of fruits and vegetables and levels of serum biomarkers among Chinese Tin miners at high risk for lung cancer.
AU  - Forman, M. R.
AU  - Zhang, J.
AU  - Gunter, E.
AU  - Yao, S. X.
AU  - Gross, M.
AU  - Qiao, Y. L.
AU  - Graubard, B. I.
AU  - Taylor, P. R.
AU  - Keith, S.
AU  - Maher, M.
A2  - Bradlow, H. L.
A2  - Fishman, J.
A2  - Osborne, M. P.
JO  - Annals of the New York Academy of Sciences
JF  - Annals of the New York Academy of Sciences
Y1  - 1999///
VL  - 889
SP  - 230
EP  - 239
CY  - New York; USA
PB  - New York Academy of Sciences
SN  - 0077-8923
SN  - 1573311987\1573311995
AD  - Forman, M. R.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, 6006 Executive Boulevard, Suite 321, MSC 7058, Bethesda, MD 20892-7058, USA.
N1  - Accession Number: 20013018090.  Publication Type: Journal Article; Conference paper.  Language: English.  Number of References: 35 ref. Registry Number: 7440-31-5.  Subject Subsets: Tropical Diseases; Human Nutrition
KW  - diets
KW  - fruits
KW  - intake
KW  - lung cancer
KW  - lungs
KW  - miners
KW  - neoplasms
KW  - occupational hazards
KW  - tin
KW  - vegetables
KW  - China
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developing Countries
KW  - East Asia
KW  - Asia
KW  - cancers
KW  - People's Republic of China
KW  - vegetable crops
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
KW  - Human Nutrition (General) (VV100) 
KW  - Diet Studies (VV110) 
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
T1  - Detection of Alexandrium tamarensis by rapid PCR analysis.
AU  - Wakabayashi, T.
AU  - Messing, A.
AU  - Brenner, M.
JO  - BioTechniques (Euro Edition)
JF  - BioTechniques (Euro Edition)
Y1  - 1999///
IS  - 34
SP  - 48
EP  - 52
SN  - 0736-6205
AD  - Wakabayashi, T.: National Institute of Neurological Disorders and Stroke, NIH Bethesda, MD, USA.
N1  - Accession Number: 19992212349.  Publication Type: Journal Article.  Language: English.  Number of References: 20 ref.
N2  - Alexandrium tamarensis is a toxigenic dinoflagellate found in coastal waters worldwide. A critical factor in alleviating the health and economic threats posed by this species is the development of a rapid and reliable method for detection. This study stream-lined a labour- and resource-intensive protocol for the isolation of A. tamarensis ribosomal DNA (rDNA). Subcultures of A. tamarensis were established in water samples from several coastal Atlantic sites. A commercial DNA isolation kit protocol for cultured cells was used for isolation of the dinoflagellate DNA. Samples were amplified by PCR using primers specific for a 700-bp sequence of A. tamarensis rDNA. It was determined that this method facilitated the detection of 10-4 ng/µL of A. tamarensis DNA. Furthermore, the kit enabled A. tamarensis to be isolated from the water sources with little signal degradation. This is a valuable technique for the rapid detection of A. tamarensis, even before cell numbers are large enough for morphological identification.
KW  - aquatic plants
KW  - detection
KW  - phytoplankton
KW  - sea water
KW  - toxicology
KW  - Alexandrium
KW  - algae
KW  - Gonyaulacales
KW  - plants
KW  - plants
KW  - aquatic plants
KW  - aquatic organisms
KW  - eukaryotes
KW  - Gonyaulacaceae
KW  - Gonyaulacales
KW  - Dinophyceae
KW  - Dinoflagellida
KW  - Sarcomastigophora
KW  - Protozoa
KW  - invertebrates
KW  - animals
KW  - dinoflagellates
KW  - Goniodomataceae
KW  - seawater
KW  - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW  - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Cancer in Thailand. Vol. II, 1992-1994.
AU  - Deerasamee, S.
AU  - Martin, N.
AU  - Sontipong, S.
AU  - Sriamporn, S.
AU  - Sriplung, H.
AU  - Srivatanakul, P.
AU  - Vatanasapt, V.
AU  - Parkin, D. M.
AU  - Ferlay, J.
T2  - IARC Technical Report
JO  - IARC Technical Report
JF  - IARC Technical Report
Y1  - 1999///
IS  - 34
SP  - J + 135
EP  - J + 135
CY  - Geneva; Switzerland
PB  - World Health Organization
SN  - 928322406X
AD  - Deerasamee, S.: Ministry of Public Health, National Cancer Institute, Department of Medical Services, Thailand.
N1  - Accession Number: 20002016062.  Publication Type: Annual report.  Language: English.  Number of References: 6 pp. of ref. Subject Subsets: Tropical Diseases
N2  - This publication presents data on cancer incidence collected from 5 population-based cancer registries in Thailand (Bangkok and its vicinity, Chiang Mai Province, Khon Kaen Province, Lampang Province and Songkhla Province) and comparison is made with data on cancer incidence from other parts of the world. It discusses the importance of different risk factors, with particular emphasis on studies carried out in populations in Thailand.
KW  - epidemiology
KW  - human diseases
KW  - incidence
KW  - neoplasms
KW  - Thailand
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - ASEAN Countries
KW  - Developing Countries
KW  - South East Asia
KW  - Asia
KW  - cancers
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002016062&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Antioxidants and the prevention of cancer.
AU  - Greenwald, P.
AU  - McDonald, S. S.
A2  - Basu, T.K.
A2  - Temple, N.J.
A2  - Garg, M.L.
T2  - Antioxidants in human health and disease.
Y1  - 1999///
CY  - Wallingford; UK
PB  - CABI Publishing
SN  - 0851993346
AD  - Greenwald, P.: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA.
N1  - Accession Number: 19991409884.  Publication Type: Conference paper; Book chapter.  Language: English.  Number of References: 5 pp. of ref. Registry Number: 50-81-7, 7235-40-7, 476-66-4, 7782-49-2.  Subject Subsets: Human Nutrition
N2  - This chapter examines the role of antioxidants in cancer prevention. Areas of focus include: Micronutrients - β-carotene, vitamin E, ascorbic acid, selenium; phytochemicals - phenolic compounds, tea extracts, green tea polyphenols, curcumin, ellagic acid; carotenoids; and large-scale, randomized intervention trials.
KW  - antioxidants
KW  - ascorbic acid
KW  - beta-carotene
KW  - carotenoids
KW  - ellagic acid
KW  - neoplasms
KW  - phytochemicals
KW  - polyphenols
KW  - prevention
KW  - selenium
KW  - tea
KW  - trace elements
KW  - vitamins
KW  - Camellia sinensis
KW  - man
KW  - Camellia
KW  - Theaceae
KW  - Theales
KW  - dicotyledons
KW  - angiosperms
KW  - Spermatophyta
KW  - plants
KW  - eukaryotes
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - cancers
KW  - microelements
KW  - tetraterpenoids
KW  - vitamin C
KW  - Crop Produce (QQ050) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409884&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995.
AU  - Ries, L. A. G.
AU  - Smith, M. A.
AU  - Gurney, J. G.
AU  - Linet, M.
AU  - Tamra, T.
AU  - Young, J. L.
AU  - Bunin, G. R.
A2  - Ries, L. A. G.
A2  - Smith, M. A.
A2  - Gurney, J. G.
A2  - Linet, M.
A2  - Tamra, T.
A2  - Young, J. L.
A2  - Bunin, G. R.
T2  - Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995
T3  - NIH Pub. No. 99-4649
Y1  - 1999///
CY  - Bethesda; USA
PB  - National Cancer Institute (NCI)
AD  - Ries, L. A. G.: Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd., Executive Plaza North, Room 343J, Bethesda, MD 20892-7352, USA.
N1  - Accession Number: 20083240999.  Publication Type: Book.  Note: NIH Pub. No. 99-4649 Language: English.  Subject Subsets: Public Health
N2  - This monograph assembles the most detailed information available on the incidence of childhood cancer in the USA. These population-based data is important in furthering the understanding of the variations in childhood cancer by histological type and primary site and the variations in incidence of these cancers over time. The monograph provides information about childhood cancer incidence and mortality rates that can enhance the level of public discourse, and it can be used in planning research that will help us to better understand these cancers and their causes. The monograph details incidence for 1975-1995 and survival by International Classification of Childhood Cancer (ICCC) group and by patient demographic characteristics. For each of the major ICCC groups, information on known risk factors is also presented. The monograph emphasizes not only ICCC group but also age as important factors in childhood cancer incidence. The cancers discussed include those occurring in children younger than 15 years of age as well as those occurring in adolescents up to age 19 years. The monograph highlights the importance of the SEER Program as a national resource.
KW  - adolescents
KW  - children
KW  - disease incidence
KW  - epidemiology
KW  - histology
KW  - histopathology
KW  - human diseases
KW  - neoplasms
KW  - risk factors
KW  - USA
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - cancers
KW  - teenagers
KW  - United States of America
KW  - Non-communicable Human Diseases and Injuries (VV600) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083240999&site=ehost-live&scope=site
UR  - http://seer.cancer.gov/publications/childhood/foreword.pdf
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Lipid mediators in a paradigm shift: balance between ω-6 and ω-3.
AU  - Lands, W. E. M.
A2  - Sim, J. S.
A2  - Nakai, S.
A2  - Guenter, W.
T2  - Egg nutrition and biotechnology.
Y1  - 1999///
CY  - Wallingford; UK
PB  - CABI Publishing
SN  - 0851993303
AD  - Lands, W. E. M.: National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
N1  - Accession Number: 20001410893.  Publication Type: Book chapter.  Language: English.  Number of References: 6 pp. of ref. Subject Subsets: Human Nutrition
N2  - There are two contrasting hypotheses regarding cardiovascular mortality: one concerns excessive molecules circulating in the plasma and the other concerns excessive inflammatory, proliferative signals in the vascular wall. Some lipids mediate cellular actions, whereas other lipids serve as surrogate indices of pathology. Successful intervention in decreasing myocardial infarctions by low-dose aspirin suggests that a prostaglandin-related n-6 eicosanoid (thromboxane A2) mediates fatal thrombotic events. Also, successful intervention in decreasing cardiovascular death by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors suggests that an isoprenoid derivative (prenylated oncogene?) mediates inflammatory/proliferative processes in atherosclerotic plaques. Inflammatory, proliferative events are also mediated by excessive formation and function of n-6 eicosanoids associated with release of cytokines, platelet-activating factor (PAF) and PAF mimics, as well as reactive oxygen (ROS), all of which cause further pathophysiology. In this context, two hydrolytic enzymes carried on high-density lipoproteins (HDLs), PAF-acetylhydrolase and paraoxonase, diminish the pathological effects of PAF mimics carried on oxidized low-density lipoproteins (LDLs). It was reported 25 years ago that the formation of n-6 eicosanoids is diminished competitively by the δ-3 type of highly unsaturated fatty acid (HUFA) released from tissue phospholipids when 20:4n-6 is released. In this way, dietary n-3 fats diminish n-6 eicosanoid-mediated risks of thrombosis, leucocyte adhesion, vascular wall inflammation and myocardial arrhythmia. Future progress may come from carefully interpreting known metabolic patterns that maintain HUFA precursors of n-6 eicosanoids in tissue lipids. Clinical targets for healthy subjects are 20-26 kg/m² for body mass index 70-110 mg/dl for blood glucose, less than 200 mg/dl for cholesterol, and it seems likely that another useful clinical target will be more than 45% for the proportion of n-3 HUFA in plasma phospholipid HUFA.
KW  - cardiovascular diseases
KW  - polyenoic fatty acids
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - polyunsaturated fatty acids
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410893&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Laboratory maintenance of phlebotomine sand flies.
AU  - Modi, G. B.
AU  - Rowton, E. D.
A2  - Maramorosch, K.
A2  - Mahmood, F.
T2  - Maintenance of human, animal, and plant pathogen vectors.
Y1  - 1999///
CY  - Enfield, NH; USA
PB  - Science Publishers, Inc.
SN  - 1578080495
AD  - Modi, G. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
N1  - Accession Number: 20000507910.  Publication Type: Book chapter.  Language: English.  Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology
N2  - A method for laboratory rearing and maintenance of phlebotomine sandflies is described. The method has been used for the past several years, and currently, 11 laboratory colonies of sandflies (of the species Phlebotomus argentipes, P. duboscqi, P. sergenti, P. papatasi, Lutzomyia longipalpis and Sergentomyia schwetzi) are being maintained by this method at the Walter Reed Army Institute of Research, Washington, DC, USA. Briefly, the method consists of holding the adult flies in 31-cm² Lexan cages on apple slices as a source of sugar. The females are fed on anaesthetized golden hamsters for their blood meal and a day after the blood meal, they are transferred into polycarbonate (containing a 2-cm layer of plaster of paris at the bottom) containers for oviposition. The females are fed on 50% karo until the oviposition is complete. The larvae are fed on an aged mixture of rabbit faeces and rabbit chow. The entire life cycle of sandflies, including the blood feeding, holding the gravid females and immature stages takes place inside the reach-in incubators at 26.5-27.0°C and 80-95% RH. A brief methodology is also given for collection of the sandflies from their natural habitats and their transportation to the laboratory for initiating colonies of these flies.
KW  - oviposition
KW  - rearing techniques
KW  - reviews
KW  - techniques
KW  - Diptera
KW  - golden hamsters
KW  - Lutzomyia
KW  - Lutzomyia longipalpis
KW  - Phlebotominae
KW  - Phlebotomus
KW  - Phlebotomus argentipes
KW  - Phlebotomus duboscqi
KW  - Phlebotomus papatasi
KW  - Phlebotomus sergenti
KW  - Psychodidae
KW  - rabbits
KW  - Sergentomyia
KW  - Sergentomyia schwetzi
KW  - insects
KW  - Hexapoda
KW  - arthropods
KW  - invertebrates
KW  - animals
KW  - eukaryotes
KW  - Mesocricetus
KW  - Cricetinae
KW  - Muridae
KW  - rodents
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - Phlebotominae
KW  - Psychodidae
KW  - Diptera
KW  - Lutzomyia
KW  - Phlebotomus
KW  - Leporidae
KW  - Lagomorpha
KW  - Sergentomyia
KW  - Other Invertebrate Culture (Not Aquaculture) (LL030) 
KW  - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW  - Techniques and Methodology (ZZ900) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000507910&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Reduction of the incidence of metachronous adenomas of the large bowel by means of antioxidants: a double blind randomized trial.
AU  - Bonelli, L.
AU  - Camoriano, A.
AU  - Ravelli, P.
AU  - Missale, G.
AU  - Bruzzi, P.
AU  - Aste, H.
A2  - Kumpulainen, J. T.
A2  - Salonen, J. T.
T2  - Natural antioxidants and anticarcinogens in nutrition, health and disease.
Y1  - 1999///
CY  - Cambridge; UK
PB  - Royal Society of Chemistry
SN  - 085404793X
AD  - Bonelli, L.: Unit of Clinical Epidemiology and Trial, National Cancer Institute of Genova, Italy.
N1  - Accession Number: 19991414766.  Publication Type: Conference paper; Book chapter.  Language: English.  Number of References: 28 ref. Registry Number: 50-81-7, 68-26-8, 7782-49-2, 1406-18-4, 7440-66-6.  Subject Subsets: Human Nutrition
N2  - This study evaluated: the efficacy of a combination of selenium, zinc and antioxidant vitamins in reducing the incidence of metachronous adenomas of the large bowel after endoscopic polypectomy; the compliance of the patients to treatment and follow-up procedures; and the side effects associated with the treatment.
KW  - antioxidants
KW  - ascorbic acid
KW  - colon
KW  - colorectal cancer
KW  - neoplasms
KW  - retinol
KW  - selenium
KW  - trace elements
KW  - vitamin E
KW  - vitamins
KW  - zinc
KW  - Italy
KW  - man
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Developed Countries
KW  - European Union Countries
KW  - Mediterranean Region
KW  - OECD Countries
KW  - Southern Europe
KW  - Europe
KW  - axerophthol
KW  - cancers
KW  - microelements
KW  - vitamin A
KW  - vitamin A alcohol
KW  - vitamin A1
KW  - vitamin C
KW  - Physiology of Human Nutrition (VV120) 
KW  - Nutrition Related Disorders and Therapeutic Nutrition (VV130) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414766&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - Natural product drug discovery and development. The United States National Cancer Institute role.
AU  - Cragg, G. M.
AU  - Boyd, M. R.
AU  - Khanna, R.
AU  - Newman, D. J.
AU  - Sausville, E. A.
A2  - Romeo, J. T.
T2  - Phytochemicals in human health protection, nutrition, and plant defense.
Y1  - 1999///
CY  - New York; USA
PB  - Kluwer Academic/Plenum Publishers
SN  - 0306462036
AD  - Cragg, G. M.: Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA.
N1  - Accession Number: 20000309882.  Publication Type: Book chapter.  Language: English.  Number of References: 41 ref. Subject Subsets: Horticultural Science
KW  - drugs
KW  - medicinal plants
KW  - natural products
KW  - research
KW  - USA
KW  - APEC countries
KW  - Developed Countries
KW  - North America
KW  - America
KW  - OECD Countries
KW  - drug plants
KW  - medicinal herbs
KW  - medicines
KW  - National Cancer Institute
KW  - officinal plants
KW  - pharmaceuticals
KW  - studies
KW  - United States of America
KW  - Non-food/Non-feed Plant Products (SS200) 
KW  - Pharmacology (VV730) (New March 2000)
KW  - Research (AA500) 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000309882&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - GEN
T1  - A nutrient-permeable channel on the intraerythrocytic malaria parasite.
AU  - Desai, S. A.
A2  - Bock, G. R.
A2  - Cardew, G.
T2  - Transport and trafficking in the malaria-infected erythrocyte. Proceedings of a Symposium held at the Novartis Foundation, London, UK, 26-28 January 1999
T3  - Novartis Foundation Symposium 226
Y1  - 1999///
CY  - Chichester; UK
PB  - John Wiley & Sons Ltd
SN  - 0471998931
AD  - Desai, S. A.: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Building 4, Room 126, 9000, Rockville Pike, Bethesda, MD 20814, USA.
N1  - Accession Number: 20003010172.  Publication Type: Book chapter; Conference paper.  Note: Novartis Foundation Symposium 226 Language: English.  Number of References: 11 ref. Subject Subsets: Tropical Diseases; Protozoology
N2  - The intraerythrocytic malaria parasite Plasmodium falciparum faces at least 3 membranous barriers to the acquisition of nutrients from serum: the human erythrocyte membrane, the parasitophorous vacuole membrane (PVM) and the parasite plasma membrane. The PVM is a specialized parasite-derived membrane that separates the parasite from erythrocyte cytosol. The patch clamp method was used to identify and characterize the main transport pathway on the PVM. Gigaohm seals, formed on mature freed trophozoites, revealed a 140 pS channel permeable to both cations and anions on the PVM. This channel is present at high density, is open more than 95% of the time at the PVM resting potential, and is capable of transporting amino acids and monosaccharides across the PVM. This nutrient-permeable channel was then reconstituted into artificial lipid bilayers, where it exhibited similar slope conductances, gating, voltage dependence and permeability to soluble nutrients. In bilayers, the channel was found to have non-saturating kinetics and an effective pore diameter of 23 Å. The results suggest a high capacity molecular sieve that allows the parasite to acquire soluble nutrients from the erythrocyte cytosol.
KW  - amino acids
KW  - anions
KW  - biochemical transport
KW  - carbohydrates
KW  - cations
KW  - cell membranes
KW  - conferences
KW  - cytosol
KW  - erythrocytes
KW  - host parasite relationships
KW  - malaria
KW  - nutrients
KW  - parasitophorous vacuoles
KW  - permeability
KW  - plasma membranes
KW  - trophozoites
KW  - man
KW  - Plasmodium falciparum
KW  - Homo
KW  - Hominidae
KW  - Primates
KW  - mammals
KW  - vertebrates
KW  - Chordata
KW  - animals
KW  - eukaryotes
KW  - Plasmodium
KW  - Plasmodiidae
KW  - Haemospororida
KW  - Apicomplexa
KW  - Protozoa
KW  - invertebrates
KW  - blood red cells
KW  - cell membrane
KW  - parasite host relationships
KW  - plasmalemma
KW  - red blood cells
KW  - saccharides
KW  - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW  - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003010172&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lhh
ER  - 

TY  - JOUR
ID  - 2011-16075-001
AN  - 2011-16075-001
AU  - Martin, John Rogers
T1  - Reminiscence and gestalt theory.
JF  - Psychological Monographs
JO  - Psychological Monographs
JA  - Psychol Monogr
Y1  - 1940///
VL  - 52
IS  - 4
SP  - i
EP  - 37
CY  - US
PB  - American Psychological Association
SN  - 0096-9753
AD  - Martin, John Rogers
N1  - Accession Number: 2011-16075-001. Other Journal Title: Psychological Monographs: General and Applied; The Psychological Monographs; The Psychological Review: Monograph Supplements. Partial author list: First Author & Affiliation: Martin, John Rogers; Pennsylvania Industrial School, Huntingdon, PA, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gestalt Psychology; Intelligence; Juvenile Delinquency; Memory; Reminiscence. Minor Descriptor: Stress. Classification: Cognitive Processes (2340); Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Revised Stanford- Binet Scale for Measuring Intelligence, Form L. Methodology: Empirical Study; Quantitative Study. References Available: Y. Issue Publication Date: 1940. 
AB  - By definition, reminiscence appears after the learning process and at the time of the second recall. The first recall must result in an incomplete reproduction of the material if new, i.e., reminiscent, material is to appear in the second recall. If this hypothesis is true, the available reminiscent material having the greatest stress at the time of the second recall should show the greatest reminiscence, since its stress will give relatively greater strength to the tension set up by the second recall. In accordance with the earlier assumptions and the indicated relationship between tension and organization with the passage of time, the following should be expected if the hypothesis of this experiment is supported. Two hundred young men selected from those attending an industrial school for delinquents served as subjects. The entire school population had previously been given the Revised Stanford- Binet Scale for Measuring Intelligence, Form L, and the subjects for this experiment were selected at random from those obtaining an intelligence quotient of 80 or above. The subjects were chosen from those boys who were living in single cells, i.e., those boys who did not have cell mates. This was done to control as much as possible the probability of discussion of the experiment which would act as practice facilitating later recall. It is the purpose of this section to demonstrate the general application of the theory of reminiscence developed in this paper, supported by the gestalt theory of memory traces, to the major conditions reported in the literature as conditioning the appearance of reminiscence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - reminiscence
KW  - gestalt theory
KW  - memory
KW  - intelligence
KW  - stress
KW  - juvenile delinquents
KW  - 1940
KW  - Gestalt Psychology
KW  - Intelligence
KW  - Juvenile Delinquency
KW  - Memory
KW  - Reminiscence
KW  - Stress
KW  - 1940
DO  - 10.1037/h0093575
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16075-001&site=ehost-live&scope=site
UR  - martin.rogers@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1948-04673-001
AN  - 1948-04673-001
AU  - Blum, Harold F.
T1  - The importance of the individual in human evolution.
JF  - Scientific Monthly, New York
JO  - Scientific Monthly, New York
Y1  - 1948///
VL  - 67
SP  - 115
EP  - 118
N1  - Accession Number: 1948-04673-001. PMID: 18884650 Partial author list: First Author & Affiliation: Blum, Harold F.; National Cancer Institute, New York. Release Date: 19481101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: General Psychology (2100). Page Count: 4. Issue Publication Date: 1948. 
AB  - Discussion and illustration bear on these points, that 'genetically speaking, the individual as such is of no great evolutionary importance unless he be the bearer of a mutant gene, and even then the importance of the mutation may not manifest itself in the population as a whole for generations. In cultural evolution, on the other hand, the individual would seem to hold a position of great importance. The mechanisms in the two instances are so different that they can hardly be discussed in the same terms.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - INDIVIDUAL
KW  - IN CULTURAL VS. BIOLOGICAL EVOLUTION
KW  - EVOLUTION
KW  - BIOLOGICAL VS. CULTURAL
KW  - CULTURE
KW  - VS. HEREDITY
KW  - GENERAL
KW  - 1948
KW  - No terms assigned
KW  - 1948
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1948-04673-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1950-03123-001
AN  - 1950-03123-001
AU  - Birren, James E.
AU  - Shock, Nathan W.
T1  - Age changes in rate and level of visual dark adaptations.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1949///
VL  - 4
SP  - 330
EP  - 331
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1950-03123-001. Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; National Institutes of Health, Baltimore, Md. Other Publishers: Oxford University Press. Release Date: 19500601. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 2. Issue Publication Date: 1949. 
AB  - Source contains an abstract only. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - DARK ADAPTATION
KW  - AGE CHANGES
KW  - AGE
KW  - CHANGES
KW  - MATURITY & OLD AGE
KW  - 1949
KW  - No terms assigned
KW  - 1949
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-03123-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1951-02139-001
AN  - 1951-02139-001
AU  - Cornfield, Jerome
AU  - Mantel, Nathan
T1  - Some new aspects of the application of maximum likelihood to the calculation of the dosage response curve.
JF  - Journal of the American Statistical Association
JO  - Journal of the American Statistical Association
JA  - J Am Stat Assoc
Y1  - 1950///
VL  - 45
SP  - 181
EP  - 210
CY  - US
PB  - American Statistical Association
SN  - 0162-1459
SN  - 1537-274X
N1  - Accession Number: 1951-02139-001. Other Journal Title: Publications of the American Statistical Association; Quarterly Publication of the American Statistical Association. Partial author list: First Author & Affiliation: Cornfield, Jerome; National Cancer Institute, Bethesda, Md. Release Date: 19510401. Correction Date: 20130513. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychometrics & Statistics & Methodology (2200). Page Count: 30. Issue Publication Date: 1950. 
AB  - The estimation of the parameters of dosage response curves by the standard probit method is an interative process beginning with approximations to the parameters and using one or more cycles of computations to 'improve' these estimates until they converge. A table and method for computing the maximum likelihood solution which converges more rapidly than the standard probit method is presented. A procedure for obtaining more accurate initial approximations is given, and the problem of the bias of the maximum likelihood estimates in small samples is considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CURVE
KW  - DOSAGE RESPONSE
KW  - PARAMETERS
KW  - STATISTICS
KW  - 1950
KW  - No terms assigned
KW  - 1950
DO  - 10.2307/2280677
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-02139-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1951-02974-001
AN  - 1951-02974-001
AU  - Birren, James E.
AU  - Botwinick, Jack
T1  - Effects of age and senile psychoses upon speed of writing digits and words.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1950///
VL  - 5
SP  - 383
EP  - 384
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1951-02974-001. Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; National Institutes of Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19510501. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 2. Issue Publication Date: 1950. 
AB  - Source contains an abstract only. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - PSYCHOSIS
KW  - SENILE
KW  - & WRITING SPEED
KW  - OLD AGE
KW  - HANDWRITING
KW  - SPEED
KW  - & OLD AGE
KW  - MATURITY & OLD AGE
KW  - 1950
KW  - No terms assigned
KW  - 1950
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-02974-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1950-06167-001
AN  - 1950-06167-001
AU  - Birren, James E.
AU  - Bick, Malcolm W.
AU  - Yiengst, Marvin
T1  - The relation of structural changes of the eye and vitamin A to elevation of the light threshold in later life.
JF  - Journal of Experimental Psychology
JO  - Journal of Experimental Psychology
JA  - J Exp Psychol
Y1  - 1950/04//
VL  - 40
IS  - 2
SP  - 260
EP  - 266
CY  - US
PB  - American Psychological Association
SN  - 0022-1015
N1  - Accession Number: 1950-06167-001. PMID: 15415524 Other Journal Title: Journal of Experimental Psychology: General. Partial author list: First Author & Affiliation: Birren, James E.; National Institutes of Health, Bethesda, Md. Other Publishers: Psychological Review Company. Release Date: 19501201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Visual Thresholds; Vitamins. Minor Descriptor: Eye (Anatomy); Retina. Classification: Visual Perception (2323). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1950. Copyright Statement: American Psychological Association. 1950. 
AB  - 'Studies were made of the relation of the minimum light threshold to changes in the retina and transmission system of the eye. A total of 109 male subjects, aged 40-83, was observed… . In addition to a significant age decline in visual sensitivity as revealed by the light threshold, there was observed a high prevalence of changes in the retina, macula, and transmission system of the older eye. The light threshold of the older subjects was correlated with the presence of retinal degeneration… . Results of vitamin A determinations indicated a lack of age change in serum vitamin A and a lack of correlation between the age change in light threshold and serum vitamin A.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - structural changes
KW  - eye
KW  - vitamin A
KW  - light threshold
KW  - retina
KW  - 1950
KW  - Visual Thresholds
KW  - Vitamins
KW  - Eye (Anatomy)
KW  - Retina
KW  - 1950
DO  - 10.1037/h0057891
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-06167-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1951-06099-001
AN  - 1951-06099-001
AU  - Shock, Nathan W.
AU  - Wehrwein, Annabel
T1  - Government-conducted research in gerontology.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1951///
VL  - 6
SP  - 68
EP  - 70
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1951-06099-001. PMID: 14803703 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Shock, Nathan W.; National Institutes of Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19510901. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 3. Issue Publication Date: 1951. 
AB  - 'A total of 31 divisions and bureaus was canvassed… ', 17 were conducting research related to gerontology. Studies are underway on aging of materials, animals and man. Economic aspects of aging are included in the activities of several agencies while research on the biological aspects of aging is largely centered in the National Institutes of Health of the Public Health Service. The subject matter as well as the location of the various projects is given. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - OLD AGE
KW  - RESEARCH
KW  - GOVERNMENT
KW  - MATURITY & OLD AGE
KW  - 1951
KW  - No terms assigned
KW  - 1951
DO  - 10.1093/geronj/6.1.68
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-06099-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Shock, Nathan W.
T1  - GERONTOLOGY (LATER MATURITY).
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1951/02//
VL  - 2
IS  - 1
M3  - Article
SP  - 353
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Discusses studies of gerontology.  Quantitative measurements of auditory acuity; Increased presbyopia of older people; Changes in the structure of the eye; Motor responses in old age.
KW  - RESEARCH
KW  - GERONTOLOGY
KW  - OLD age
KW  - OLDER people
KW  - PSYCHOLOGY
N1  - Accession Number: 11290999; Shock, Nathan W. 1; Affiliations: 1: National Heart Institute, National Institutes of Health; Issue Info: 1951, Vol. 2 Issue 1, p353; Thesaurus Term: RESEARCH; Subject Term: GERONTOLOGY; Subject Term: OLD age; Subject Term: OLDER people; Subject Term: PSYCHOLOGY; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 1952-06419-001
AN  - 1952-06419-001
AU  - Botwinick, Jack
AU  - Birren, James E.
T1  - The measurement of intellectual decline in the senile psychoses.
JF  - Journal of Consulting Psychology
JO  - Journal of Consulting Psychology
JA  - J Consult Psychol
Y1  - 1951/04//
VL  - 15
IS  - 2
SP  - 145
EP  - 150
CY  - US
PB  - American Psychological Association
SN  - 0095-8891
N1  - Accession Number: 1952-06419-001. PMID: 14841282 Other Journal Title: Journal of Consulting and Clinical Psychology. Partial author list: First Author & Affiliation: Botwinick, Jack; National Institutes of Health, Bethesda, Md. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 19521001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Intelligence; Schizophrenia; Senile Psychosis. Minor Descriptor: Test Validity. Classification: Clinical Psychological Testing (2224); Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1951. Copyright Statement: American Psychological Association. 1951. 
AB  - The validity of 3 measures of intellectual deficit in the senile was determined. These measures were the Deterioration Quotient (DQ) of the Wechsler-Bellevue Scale, Copple's Senescent Decline Formula (SDF), and the Efficiency Index (EI) of the Babcock-Levy Scale. 31 patients, 60 to 70 years old, diagnosed as senile psychosis or psychosis with arteriosclerosis, were tested. There were significant differences between patients with senile psychosis and a control group on the basis of EI and SDF scores, but the DQ did not differentiate the 2 groups. EI and SDF seemed to measure different aspects of intellectual decline. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - intellectual decline
KW  - senile psychoses
KW  - intellectual deficit
KW  - psychosis
KW  - 1951
KW  - Cognitive Ability
KW  - Intelligence
KW  - Schizophrenia
KW  - Senile Psychosis
KW  - Test Validity
KW  - 1951
DO  - 10.1037/h0063318
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1952-06419-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-38642-003
AN  - 2013-38642-003
AU  - Felix, R. H.
T1  - Mental hygiene as public health practice.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1951/10//
VL  - 21
IS  - 4
SP  - 707
EP  - 716
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-38642-003. PMID: 14885383 Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health, Public Health Service, Federal Security Agency, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hygiene; Mental Health; Pathology; Psychiatry; Public Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 10. Issue Publication Date: Oct, 1951. 
AB  - The conviction that psychiatry can contribute to human welfare by working through public health techniques and agencies, as well as through the other medical channels has gained increased acceptance during the past decade. This increased acceptance has come not only on the part of the clinicians, but also on the part of health administrators and the general public. Today, we find a broad and real interest in psychiatry and an impressive demand for mental hygiene services. We can also see the evolution of a practical philosophical framework upon which mental hygiene programs are being built, and we now have at hand a number of promising public health techniques which have been adapted to mental hygiene needs. However, under any conditions the growth of mental hygiene work will continue. Furthermore, it will always be a movement through which psychiatry will be able to emphasize and demonstrate its basic teachings: that health is a totality of physical, emotional and social well-being. Stressing the positive, rather than the pathological, it aims to help people live more effectively, more productively, more in harmony with themselves and their fellows. These objectives are ambitious and far-reaching, but in his work the psychiatrist has many able and enthusiastic allies in other professions and among the public. Working together, we can be confident that these goals will be attained. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - enthusiastic allies
KW  - human welfare
KW  - mental hygiene programs
KW  - mental hygiene services
KW  - public health practice
KW  - pathology
KW  - 1951
KW  - Hygiene
KW  - Mental Health
KW  - Pathology
KW  - Psychiatry
KW  - Public Health
KW  - 1951
DO  - 10.1111/j.1939-0025.1951.tb00023.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-38642-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Hoffman, Erwin F.
T1  - MULTI-DIMENSIONAL CLASSIFICATION AND THE TRANSCRIPTION OF CANCER LITERATURE TO PUNCHED CARDS.
JO  - American Documentation
JF  - American Documentation
Y1  - 1952/01//
VL  - 3
IS  - 1
M3  - Article
SP  - 61
EP  - 70
SN  - 0096946X
AB  - This article focuses on multi-dimensional classification and the transcription of cancer literature to punched cards. The Documentation Section of the National Cancer Institute was established in October 1948, primarily to provide scientists and physicians working in the field of cancer diagnosis with bibliographic material for immediate and practical use in their respective areas of investigation. The potential value of mechanical punch cards for the handling of scientific information has been demonstrated from time to time as revealed by a review of the literature.
KW  - DOCUMENTATION
KW  - INFORMATION services
KW  - LITERATURE
KW  - CANCER
KW  - TRANSCRIPTION factors
KW  - UNITED States
N1  - Accession Number: 16888630; Hoffman, Erwin F. 1; Affiliations: 1: National Cancer Institute Documentation Section Technical Services.; Issue Info: Jan1952, Vol. 3 Issue 1, p61; Thesaurus Term: DOCUMENTATION; Thesaurus Term: INFORMATION services; Subject Term: LITERATURE; Subject Term: CANCER; Subject Term: TRANSCRIPTION factors; Subject: UNITED States; NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 10p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16888630&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 1953-04224-001
AN  - 1953-04224-001
AU  - Felix, R. H.
T1  - The technique of mass approach to the problems of mental health.
JF  - Neuropsychiatry
JO  - Neuropsychiatry
Y1  - 1952///
VL  - 2
SP  - 48
EP  - 62
N1  - Accession Number: 1953-04224-001. PMID: 12982942 Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health, Washington, D.C. Release Date: 19530601. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 15. Issue Publication Date: 1952. 
AB  - Cooperation of psychiatry with family, church, community and mass media is necessary for effective attack on mental health problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MENTAL HYGIENE
KW  - MASS APPROACH
KW  - CLINICAL PSYCHOLOGY
KW  - GUIDANCE
KW  - COUNSELING
KW  - 1952
KW  - No terms assigned
KW  - 1952
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-04224-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1953-01250-001
AN  - 1953-01250-001
AU  - Felix, R. H.
AU  - Kramer, Morton
T1  - Research in epidemiology of mental illness.
JF  - Public Health Reports
JO  - Public Health Reports
JA  - Public Health Rep
Y1  - 1952///
VL  - 67
SP  - 152
EP  - 160
CY  - US
PB  - U.S. Marine Hospital Service
SN  - 0033-3549
N1  - Accession Number: 1953-01250-001. PMID: 14900338 Other Journal Title: H.S.M.H.A. Health Reports; Health Services Reports. Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health. Bethesda, Md. Other Publishers: Association of Schools of Public Health; Elsevier Science; Oxford University Press; U. S. Public Health Service; U.S. Dept. of Health, Education, and Welfare, Health Services and Mental Health Administration. Release Date: 19530201. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 9. Issue Publication Date: 1952. 
AB  - Consideration is given to two widely quoted community surveys, Selective Service and Armed Forces data, statistics on patients in mental hospitals, and 5 current projects. 'Our basic knowledge of the distribution of mental illness in the population has distinct limitations… effective research on the community aspects of mental illness must be interdisciplinary… ' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MENTAL DISORDER
KW  - EPIDEMIOLOGY
KW  - OF MENTAL DISORDERS
KW  - BEHAVIOR DEVIATIONS
KW  - 1952
KW  - No terms assigned
KW  - 1952
DO  - 10.2307/4588020
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-01250-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Clausen, John A.
T1  - The American Veteran Back Home.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1952/04//
VL  - 17
IS  - 2
M3  - Book Review
SP  - 249
EP  - 250
SN  - 00031224
AB  - Reviews the book "The American Veteran Back Home," by Robert J. Havighurst, Walter H. Eaton, John W. Baughman and Ernest W. Burgess.
KW  - VETERANS -- United States
KW  - NONFICTION
KW  - HAVIGHURST, Robert J. (Robert James), 1900-1991
KW  - BURGESS, Ernest W.
KW  - EATON, Walter H.
KW  - BAUGHMAN, John W.
KW  - AMERICAN Veteran Back Home: A Study of Veteran Readjustment, The (Book)
N1  - Accession Number: 12770758; Clausen, John A. 1; Affiliations: 1: National Institute of Mental Health U. S. Public Health Service; Issue Info: Apr52, Vol. 17 Issue 2, p249; Subject Term: VETERANS -- United States; Subject Term: NONFICTION; Reviews & Products: AMERICAN Veteran Back Home: A Study of Veteran Readjustment, The (Book); People: HAVIGHURST, Robert J. (Robert James), 1900-1991; People: BURGESS, Ernest W.; People: EATON, Walter H.; People: BAUGHMAN, John W.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - CHAP
ID  - 1954-01048-008
AN  - 1954-01048-008
AU  - Bobbitt, Joseph M.
AU  - Clausen, John A.
T1  - Psychotherapy and its public health implications.
T2  - Psychotherapy: theory and research.
Y1  - 1953///
SP  - 171
EP  - 201
CY  - Oxford, England; New York, NY, US
PB  - Ronald Press Co.
PB  - Ronald Press Company
N1  - Accession Number: 1954-01048-008. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 19540101. Correction Date: 20151221. Publication Type: Book (0200). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Psychotherapy; Public Health. Minor Descriptor: Interpersonal Interaction; Psychotherapeutic Processes. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 31. 
AB  - The major concern in this discussion will be with what can be learned from the psychotherapeutic process that can be useful in helping individuals to achieve desirable or improved interpersonal relationships without resort to individual or even group psychotherapy. The objective is that of indicating some of the kinds of questions that should be asked, the research problems that need solution, and public health implications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychotherapy
KW  - public health
KW  - psychotherapeutic process
KW  - interpersonal relationships
KW  - 1953
KW  - Psychotherapy
KW  - Public Health
KW  - Interpersonal Interaction
KW  - Psychotherapeutic Processes
KW  - 1953
DO  - 10.1037/10572-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-01048-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-05839-006
AN  - 2009-05839-006
AU  - Meader, Ralph G.
ED  - Bush, George P.
ED  - Hattery, Lowell H.
ED  - Bush, George P., (Ed)
ED  - Hattery, Lowell H., (Ed)
T1  - Sponsoring organized university research.
T2  - Teamwork in research.
Y1  - 1953///
SP  - 46
EP  - 57
CY  - Washington, DC, US
PB  - American University Press
N1  - Accession Number: 2009-05839-006. Partial author list: First Author & Affiliation: Meader, Ralph G.; Grants and Fellowship Branch, National Cancer Institute, U. S. Public Health Service, US. Release Date: 20100927. Correction Date: 20110912. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Colleges; Education; Research and Development. Classification: Research Methods & Experimental Design (2260); Educational Psychology (3500). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12. 
AB  - The words 'organization' and 'administration' do not always have happy and respected connotations in the minds of investigators. Organizing and administering scientific research implies that there is something to be organized and administered. Actually, it implies planning and carrying out the selection of appropriate personnel, the selection and formulation of research to be done by the personnel, the selection of the methods to be used, the provision of physical and technical facilities necessary for the problem and the personnel concerned, the interpretation of the data obtained and the publication of new contributions to knowledge. Obviously, the most important of these ingredients is the selection of the appropriate personnel for if you have good investigators, they will have good ideas for research and know or develop adequate and appropriate methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - organized university research
KW  - research & development
KW  - 1953
KW  - Colleges
KW  - Education
KW  - Research and Development
KW  - 1953
DO  - 10.1037/13368-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05839-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-05839-012
AN  - 2009-05839-012
AU  - Siepert, Albert F.
ED  - Bush, George P.
ED  - Hattery, Lowell H.
ED  - Bush, George P., (Ed)
ED  - Hattery, Lowell H., (Ed)
T1  - Auxiliary services as aids to laboratory research.
T2  - Teamwork in research.
Y1  - 1953///
SP  - 104
EP  - 125
CY  - Washington, DC, US
PB  - American University Press
N1  - Accession Number: 2009-05839-012. Partial author list: First Author & Affiliation: Siepert, Albert F.; National Institutes of Health, U. S. Public Health Service, Federal Security Agency, US. Release Date: 20100927. Correction Date: 20110912. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Experimentation; Research and Development. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 22. 
AB  - Auxiliary services in a research program embrace all the technical and administrative activities which deal with furnishing men, money, and materials except those under the personal direction of the bench scientist or his immediate staff. The competence of the research staff is the biggest single factor in achieving high calibre research. But the effectiveness of supporting services can often make, or break, the physical and intellectual environment which competent investigators seek for good research. The maintenance of an environment which stimulates good research is a primary goal for any research administration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - auxiliary services
KW  - laboratory research
KW  - 1953
KW  - Experimentation
KW  - Research and Development
KW  - 1953
DO  - 10.1037/13368-012
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05839-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1954-00664-001
AN  - 1954-00664-001
AU  - Ladimer, Irving
T1  - Report of the fifth annual scientific meeting of the Gerontological Society, Inc.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1953///
VL  - 8
SP  - 94
EP  - 103
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1954-00664-001. Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Ladimer, Irving; National Institutes of Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19540101. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 10. Issue Publication Date: 1953. 
AB  - This report summarizes the papers presented at the 1952 meetings of the Gerontological Society. The information is organized under seven major categories: population trends and concepts of aging, biology and medicine, psychology, health services, economics and employment, welfare and education, and research—status and prospects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GERONTOLOGY
KW  - SOCIETY MEETING
KW  - SUMMARY
KW  - MATURITY & OLD AGE
KW  - 1953
KW  - No terms assigned
KW  - 1953
DO  - 10.1093/geronj/8.1.94
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-00664-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Felix, R. H.
AU  - Clausen, John A.
T1  - The Role of Surveys in Advancing Knowledge in the Field of Mental Health.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1953///Spring53
VL  - 17
IS  - 1
M3  - Article
SP  - 61
EP  - 70
SN  - 0033362X
AB  - In this article, authors describe components of a national mental health program and ways in which survey data can be useful to those who are charged with directing such programs in the U.S., as of March 1, 1953. In order to establish effective programs, public health administrators need to know about the extent of the problem with which they deal. There are several aspects to this need. The problem includes not only the number of people who are ill, the nature of their illness and the development and financing of services for treatment or for preventive programs, but also orientations that people have towards using these services that are available to them. Surveys can be very helpful in increasing knowledge of all these aspects of the problem. Research workers in the field of public opinion have developed a high degree of skill in defining and in reaching populations and samples of respondents, they have established some variables, which relate to the validity of responses secured in interviews.
KW  - Public opinion
KW  - METHODOLOGY
KW  - Mental health laws
KW  - Public health administration
KW  - Mental health services -- Finance
KW  - Social surveys -- Response rate
KW  - Social sciences
KW  - United States
N1  - Accession Number: 11929415; Felix, R. H. 1; Clausen, John A. 2; Affiliations: 1: Director of the National Institute of Mental Health of the Public Health Service.; 2: John Clausen is Chief of the Laboratory of Socio-environmental Studies of the same institute.; Issue Info: Spring53, Vol. 17 Issue 1, p61; Thesaurus Term: Public opinion; Thesaurus Term: METHODOLOGY; Subject Term: Mental health laws; Subject Term: Public health administration; Subject Term: Mental health services -- Finance; Subject Term: Social surveys -- Response rate; Subject Term: Social sciences; Subject: United States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - 
AU  - Ullmann, Charles A.1
T1  - The Socially Maladjusted.
JO  - Review of Educational Research
JF  - Review of Educational Research
J1  - Review of Educational Research
PY  - 1953/12//
Y1  - 1953/12//
VL  - 23
IS  - 5
CP  - 5
M3  - Article
SP  - 432
EP  - 452
SN  - 00346543
AB  - The article presents a review of several studies on socially maladjusted children. The term socially maladjusted is used in the study to refer both disorders in which emotional or personal aspects are prominent and disorders which involve interactive relationships. A study conducted by Murphy, Shirley and Witmer have pointed out that court statistics are wholly inadequate as a measure of the amount of youthful illegal behavior in the community. A number of studies have been devised to analyze the process by which maladjustment is recognize. The may be reviewed from the standpoint of factors associated with the rater and aspects of social performance. Studies of the role of teachers in the identification of problem behavior have been relatively numerous, although frequently only exploratory and fact-finding in character. The influence of experience or proved competence as a teacher on whether a given behavior is regarded as problem behavior may be inferred from studies by Jones and Slobetz.
KW  - Problem children
KW  - Behavior disorders in children
KW  - Problem children -- Education
KW  - Problem youth
KW  - Emotional problems of children
KW  - Social problems
KW  - Behavior
KW  - Children -- Attitudes
KW  - Psychology
N1  - Accession Number: 19158783; Authors: Ullmann, Charles A. 1; Affiliations:  1: National Institute of Mental Health, United States Public Health Service, Bethesda, Maryland; Subject: Problem children; Subject: Behavior disorders in children; Subject: Problem children -- Education; Subject: Problem youth; Subject: Emotional problems of children; Subject: Social problems; Subject: Behavior; Subject: Children -- Attitudes; Subject: Psychology; Number of Pages: 21p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
AU  - Hirsch, Herbert M.
T1  - Environmental Factors Influencing the Differentiation of Protoperithecia and their Relation to Tyrosinase and Melanin Formation in Neurospora crassa.
JO  - Physiologia Plantarum
JF  - Physiologia Plantarum
Y1  - 1954/01//
VL  - 7
IS  - 1
M3  - Article
SP  - 72
EP  - 97
PB  - Wiley-Blackwell
SN  - 00319317
AB  - The relation of environment to the differentiation of protoperithecia and two closely allied phenomena, tyrosinase and melanin formation, has been studied in Neurospora crassa. A temperature of 25° C is optimal as regards the formation of protoperithecia while a temperature of 35° inhibits both the formation of protoperithecia and fruitbodies. Increasing amounts of nitrogen, both organic and inorganic, depress and eventually suppress protoperithecia formation specifically; protoperithecia formed at intermediate concentrations of nitrogen appear unpigmented and are largely or wholly nonfunctional, the latter depending in a secondary way on the carbon/nitrogen ratio of the medium on which growth has taken place. The pigment present in the protoperithecia has been found to be melanic in nature: it is produced to a considerable extent only under conditions permitting the formation of functional protoperithecia. Mycelia grown under conditions permitting optimal protoperithecia formation show strong tyrosinase activity which makes its appearance concomitant with or slightly precedes protoperithecial formation; the greatest increase in rate of protoperithecia production coincides with maximal tyrosinase activity of the mycelium. Tyrosinase and melanin are low or absent in mycelia growth at 35°. Mycelia in which protoperithecia formation bas been completely suppressed through the addition of organic nitrogen show very little tyrosinase activity after 7 days' growth and tyrosine is oxidized only to a red pigment; after 14 days a strong tyrosinase can be demonstrated which rapidly oxidizes tyrosine to melanin, but during actual growth only a very small amount of melanin deposition takes place. This inhibition is not due lo the presence of sulfur-containing substances. The possible significance of these findings is discussed. By appropriate changes in the relative and absolute amounts of carbon and nitrogen different stages in the sexual cycle of the organism can be affected, but any condition which prevents the exhaustion of nitrate (and possibly nitrogen in general) always affects in a deleterious manner both the number and normal functioning of the protoperithecia formed. The processes of fertilization and fruit formation, on the other hand, are not greatly affected by the presence of nitrate. Use of tyrosinase inhibitors suppresses the formation of protoperithecia and melanin more or less completely; some other enzyme inhibitors used do not show the same effect and apparently have another site of action. The question of whether tyrosine metabolism has a causal relation to the differentiation and normal functioning of protoperithecia, or whether tyrosinase and melanin are invariable, though accidental, concomitants of protoperithecial formation is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Nitrogen
KW  - Enzyme inhibitors
KW  - Cell differentiation
KW  - Melanins
KW  - Melanocytes
KW  - Amino acids
KW  - Neurospora crassa
N1  - Accession Number: 15770136; Hirsch, Herbert M. 1; Affiliations: 1: U.S. Public Health Service Research Fellow of the National Institutes of Health, Institute of Genetics, University of Copenhagen.; Issue Info: 1954, Vol. 7 Issue 1, p72; Thesaurus Term: Nitrogen; Thesaurus Term: Enzyme inhibitors; Subject Term: Cell differentiation; Subject Term: Melanins; Subject Term: Melanocytes; Subject Term: Amino acids; Subject Term: Neurospora crassa; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 26p; Document Type: Article
L3  - 10.1111/1399-3054.ep15770136
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15770136&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 1955-04352-001
AN  - 1955-04352-001
AU  - Bloch, Donald A.
T1  - Some concepts in the treatment of delinquency.
JF  - Children
JO  - Children
JA  - Children
Y1  - 1954///
VL  - 1
SP  - 49
EP  - 56
CY  - US
PB  - United States Children’s Bureau
SN  - 0009-4064
N1  - Accession Number: 1955-04352-001. Other Journal Title: Children Today. Partial author list: First Author & Affiliation: Bloch, Donald A.; National Institute of Mental Health, Washington, D. C. Release Date: 19550301. Correction Date: 20130617. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 8. Issue Publication Date: 1954. 
AB  - The author maintains that delinquency seen as an interpersonal integration has implications for treatment. The concept of a defense in depth on a community level is a useful one. The treatment facilities are available; child guidance, court, and institutional levels are integrated with each other and staffed to some considerable degree by the same personnel. This gives opportunity for a comprehensive treatment program. Anxiety levels are reduced; the continuity of relationship is maintained. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - JUVENILE DELINQUENCY
KW  - TREATMENT OF
KW  - CRIME & DELINQUENCY
KW  - 1954
KW  - No terms assigned
KW  - 1954
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1954-08699-001
AN  - 1954-08699-001
AU  - Miller, Alan D.
T1  - The institute of interpersonal relationships in public health: an evaluation.
JF  - Mental Hygiene. New York
JO  - Mental Hygiene. New York
Y1  - 1954///
VL  - 38
SP  - 85
EP  - 106
N1  - Accession Number: 1954-08699-001. PMID: 13132517 Partial author list: First Author & Affiliation: Miller, Alan D.; National Institute of Mental Health, College Park, Md. Release Date: 19541101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 22. Issue Publication Date: 1954. 
AB  - A study of the responses on a specially designed questionnaire aimed at the evaluation of a public health institute on interpersonal relationships. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CLINICAL PSYCHOLOGY
KW  - GUIDANCE
KW  - COUNSELING
KW  - 1954
KW  - No terms assigned
KW  - 1954
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-08699-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1955-02917-001
AN  - 1955-02917-001
AU  - Cholden, Louis
T1  - Some psychiatric problems in the rehabilitation of the blind.
JF  - Bulletin of the Menninger Clinic
JO  - Bulletin of the Menninger Clinic
JA  - Bull Menninger Clin
Y1  - 1954///
VL  - 18
SP  - 107
EP  - 112
CY  - US
PB  - Guilford Publications
SN  - 0025-9284
N1  - Accession Number: 1955-02917-001. PMID: 13149996 Partial author list: First Author & Affiliation: Cholden, Louis; National Institute of Mental Health, Bethesda, Md. Release Date: 19550201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: 1954. 
AB  - The adult who loses his sight usually reacts with a state of shock. As he begins to experience emotions again, his behavior and feelings resemble those in reactive depression. Before the patient can accept the reality of his blindness, he needs to experience this depression and efforts should not be made to prevent or abort it. It is a necessary precursor to relearning. He must believe that he is disabled but that he can learn to live with his disability. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - REHABILITATION
KW  - BLIND
KW  - PSYCHIATRIC PROBLEMS
KW  - PHYSICALLY HANDICAPPED
KW  - 1954
KW  - No terms assigned
KW  - 1954
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-02917-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1955-05417-001
AN  - 1955-05417-001
AU  - Birren, James E.
AU  - Allen, William R.
AU  - Landau, H. G.
T1  - The relation of problem length in simple addition to time required, probability of success and age.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1954///
VL  - 9
SP  - 150
EP  - 161
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1955-05417-001. PMID: 13163370 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; National Institute of Mental Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19550401. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 12. Issue Publication Date: 1954. 
AB  - An analysis was made of the task of simple arithmetic addition. Time required (T) and probability of success (P) were studied as a function of the age of the subjects and the length of a single column of digits to be added. Data are reported on 413 subjects between the ages of 16 and 90 years. The elderly were slower for all lengths of problems, and showed less accuracy with increased length of problem. Empirical equations fitted to the data seem to be approximations to rational equations derived from an analysis of the nature of the task. A simulated physical system or model was described which incorporates assumed characteristics of the human subject doing addition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - OLD AGE
KW  - & ADDITION PROFICIENCY
KW  - ARITHMETIC
KW  - ADDITION
KW  - & AGE
KW  - MATURITY & OLD AGE
KW  - 1954
KW  - No terms assigned
KW  - 1954
DO  - 10.1093/geronj/9.2.150
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-05417-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1955-07045-001
AN  - 1955-07045-001
AU  - Birren, James E.
T1  - Age changes in mental abilities.
JF  - Journal of Business
JO  - Journal of Business
Y1  - 1954///
VL  - 27
SP  - 156
EP  - 163
N1  - Accession Number: 1955-07045-001. Partial author list: First Author & Affiliation: Birren, James E.; National Institute of Mental Health, Bethesda, Md. Release Date: 19550501. Correction Date: 20161128. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 8. Issue Publication Date: 1954. 
AB  - Psychological research on age changes in mental ability is reviewed in relation to the problem of choosing an optimum age for retirement. The topics discussed are speed, intelligence tests, verbal ability, learning and memory, creativity, education, mental disease and research needs. 'Mental abilities vary greatly in the extent to which they change with age… . Jobs requiring rapid integration of incoming serial information and demanding a response in a limited time are particularly unsuited for the abilities of older workers.' In view of the differences in characteristics of jobs and individuals '… decisions about continued employment, job shifting, or retirement might better be made over a span of years than at any fixed age.' 37 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - OLD AGE
KW  - MENTAL
KW  - ABILITIES
KW  - RETIREMENT
KW  - & MENTAL ABILITIES
KW  - ABILITY
KW  - AGE CHANGES
KW  - & RETIREMENT
KW  - MATURITY & OLD AGE
KW  - 1954
KW  - No terms assigned
KW  - 1954
DO  - 10.1086/294020
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-07045-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-001
AN  - 2009-06034-001
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Scope of the problem and methods of study.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 1
EP  - 5
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-001. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Cardiovascular Disorders; Cardiovascular Reactivity; Cardiovascular System. Minor Descriptor: Essential Hypertension. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 5. 
AB  - Our aim in the present study was to investigate as many aspects of cardiovascular function as we could and to observe the circumstances under which each one was altered. This chapter describes the scope and methods of the study. Ss were 216 patients with various cardiovascular disturbances were collected and followed; 135 presumably healthy Ss swerved as controls. Circulatory responses in areas of the human body other than those traditionally considered to be cardiovascular have been included in the present study. For detecting alterations in cardiovascular dynamics, only those methods which afforded a minimum of discomfort to the patient and the least possible disturbance of the experimental situation were used. Prominent among experimentally applied stimuli has been the 'stressful interview,' in which topics of known threatening significance in the subject's life were introduced for discussion while the indicators of cardiovascular function were being recorded. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cardiovascular function
KW  - hypertension
KW  - stressful interview
KW  - cardiovascular reactivity
KW  - 1955
KW  - Cardiovascular Disorders
KW  - Cardiovascular Reactivity
KW  - Cardiovascular System
KW  - Essential Hypertension
KW  - 1955
DO  - 10.1037/14077-001
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-002
AN  - 2009-06034-002
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Circulatory adjustments associated with muscular effort.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 6
EP  - 16
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-002. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Cardiovascular Disorders; Cardiovascular Reactivity; Exercise; Expectations; Heart Disorders. Minor Descriptor: Essential Hypertension; Fatigue; Muscles. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 11. 
AB  - Exercise involving muscular work, requiring, as it does, an increase in peripheral circulation, calls forth a relatively uniform cardiovascular response. Ss were 35 subjects: 8 were healthy asymptomatic persons, 11 had complaints of palpitation and fatigability with or without exertional dyspnea but no demonstrable heart disease, and the remaining 16 had hypertensive, arteriosclerotic, rhematic or congenital heart disease. The extent and duration of the circulatory disturbance in these patients, however, did not correspond necessarily with the muscular work performed. In fact, the same response could be induced during rest merely by the anticipation of exercise and was often observed under circumstances of emotional stress without conscious anticipation of muscular effort. This was true whether the indicator of reduced exercise tolerance was the pulse rate, the height of the IJ wave of the ballistocardiogram, or the form of the electrocardiogram. It may be the symptoms of neurocirculatory asthenia are related to these disturbances in circulatory dynamics and to the fact that the 'exercise' pattern of hemodynamic adjustment was often invoked without exercise but during contemplation of troublesome life situations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - heart disease
KW  - hypertension
KW  - cardiovascular disorders
KW  - cardiovascular activity
KW  - muscular work
KW  - exercise
KW  - cardiovascular response
KW  - fatigue
KW  - palpitations
KW  - anticipation
KW  - 1955
KW  - Cardiovascular Disorders
KW  - Cardiovascular Reactivity
KW  - Exercise
KW  - Expectations
KW  - Heart Disorders
KW  - Essential Hypertension
KW  - Fatigue
KW  - Muscles
KW  - 1955
DO  - 10.1037/14077-002
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-003
AN  - 2009-06034-003
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Circulatory adjustments involving rhythm of the heart.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 17
EP  - 30
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-003. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Cardiovascular Reactivity; Heart Disorders; Heart Rate; Stress; Stress Reactions. Minor Descriptor: Adaptation; Arrhythmias (Heart); Emotional States; Fibrillation (Heart); Tachycardia; Threat. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14. 
AB  - It has been observed that arrhythmias, including paroxysmal auricular tachycardia, extrasystoles, auricular fibrillation, and even the more serious paroxysmal ventricular tacycardia, occur in association with troublesome events in the day-to-day experiences of individuals who have no other detectable evidence of heart disease. It would appear that this variety of disorders of cardiac rhythm may be precipitated by or possibly fundamentally related to threats arising out of the life situation. It is certainly unnecessary to postulate underlying structural disease of the myocardium as a cause of arrhythmias even in the case of such potentially serious disorders as auricular fibrillation and ventricular tachycardia. It is noteworthy that paroxysmal ventricular tachycardia has also been reported by Harvey and Levine in association with emotional stress. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - circulatory adjustment
KW  - arrhythmias
KW  - extrasystoles
KW  - auricular fibrillation
KW  - paroxysmal ventricular tachycardia
KW  - stress
KW  - emotional stress
KW  - heart disease
KW  - threat
KW  - 1955
KW  - Cardiovascular Reactivity
KW  - Heart Disorders
KW  - Heart Rate
KW  - Stress
KW  - Stress Reactions
KW  - Adaptation
KW  - Arrhythmias (Heart)
KW  - Emotional States
KW  - Fibrillation (Heart)
KW  - Tachycardia
KW  - Threat
KW  - 1955
DO  - 10.1037/14077-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-004
AN  - 2009-06034-004
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Circulatory adjustments involving peripheral vessels.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 31
EP  - 44
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-004. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Blood Vessels; Cardiovascular Reactivity; Cardiovascular System; Physical Disorders; Stress. Minor Descriptor: Allergic Skin Disorders; Cardiovascular Disorders; Eczema; Migraine Headache. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14. 
AB  - The peripheral vasculature is capable of a rich variety of responses, local, regional and general, to many stimuli. Such changes in vascular function produce thermal, nutritive and other effects. Many important disturbances involving peripheral vessels are not customarily classified among cardiovascular disorders. These include vascular headache, Raynaud's syndrome, hives, eczema, and various disorders of mucous membranes. The vasomotor mechanisms which appear to be responsible for these phenomena have been shown to be set in motion by a variety of stimuli, including situations or events which have a threatening significance to the individual. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Circulatory adjustment
KW  - periperal vessels
KW  - peripheral vasculature
KW  - cardiovascular reactivity
KW  - threat
KW  - life stress
KW  - physical disorders
KW  - vascular headache
KW  - Raynaud's syndrome
KW  - hives
KW  - eczema
KW  - mucous membrane disorders
KW  - 1955
KW  - Blood Vessels
KW  - Cardiovascular Reactivity
KW  - Cardiovascular System
KW  - Physical Disorders
KW  - Stress
KW  - Allergic Skin Disorders
KW  - Cardiovascular Disorders
KW  - Eczema
KW  - Migraine Headache
KW  - 1955
DO  - 10.1037/14077-004
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-005
AN  - 2009-06034-005
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Essential hypertension—Natural history and symptomatology.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 45
EP  - 55
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-005. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Disease Course; Essential Hypertension; Stress Reactions; Symptoms. Minor Descriptor: Adaptation; Stress; Threat. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11. 
AB  - Another disorder which appears initially to involve mainly peripheral vessels is essential hypertension. The diagnosis is one of exclusion and is made only in the absence of a discoverable reason for hypertension, such as congenital vascular anomaly, endocrine tumor or primary renal disorder. The label 'essential hypertension' is attached to a patient who is consistently observed to have an elevation of systolic and diastolic blood pressure at the times when he is examined by his physician. It is an old observation, and very easily confirmed, that patients with essential hypertension, and normal subjects as well, display an increase in arterial pressure when brought into certain situations involving threats to their personal security. The pertinence of these responses to the initial causation or ultimate perpetuation of sustained arterial hypertension, however, is not established. The investigator who studies hypertension is handicapped by the lack of relationship between height of the blood pressure and the presence or absence of symptoms and the lack of uniformity and predictability of the natural course. Some of the circumstances under which hypertension is observed have been reviewed, but it appeared more fruitful to focus attention on some of the underlying or associated hemodynamic adjustments which could be measured and recorded. Since the ballistocardiograph was used in many of these observations a description of the instrument and of its range of usefulness and reliability seems indicated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - essential hypertension
KW  - stress reaction
KW  - threat
KW  - stress
KW  - symptoms
KW  - hemodynamic adjustment
KW  - natural history
KW  - 1955
KW  - Disease Course
KW  - Essential Hypertension
KW  - Stress Reactions
KW  - Symptoms
KW  - Adaptation
KW  - Stress
KW  - Threat
KW  - 1955
DO  - 10.1037/14077-005
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-006
AN  - 2009-06034-006
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - The ballistocardiograph.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 56
EP  - 67
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-006. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Blood Pressure; Cardiography; Cardiovascular Reactivity; Stress; Stress Reactions. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12. 
AB  - Ballistocardiography as a convenient if inexact indicator of cardiovascular dynamics is reviewed. It is pointed out that the method lends itself to prolonged and frequently repeated observation in a single subject and that the data thus obtained are satisfactorily reproducible. Alterations in the pattern under stress have been shown to correspond to or to combine the characteristics of the changes induced by subcutaneous injection with epinephrine on the one hand (increased cardiac output and reduced peripheral resistance), or with norepinephrine on the other (increased peripheral resistance and reduced cardiac output). In interpreting the data, however, no inferences are made concerning actual cardiac output or peripheral resistance, but rather the terms are used to indicate the characteristic and readily studied changes in the ballistocardiographic tracing. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - ballistocardiography
KW  - cardiovascular dynamics
KW  - stress
KW  - stress reactions
KW  - 1955
KW  - Blood Pressure
KW  - Cardiography
KW  - Cardiovascular Reactivity
KW  - Stress
KW  - Stress Reactions
KW  - 1955
DO  - 10.1037/14077-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-007
AN  - 2009-06034-007
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Measurement of hemodynamics in essential hypertension.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 68
EP  - 119
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-007. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter; Column/Opinion. Book Type: Classic Book. Language: English. Major Descriptor: Blood Pressure; Cardiovascular Reactivity; Cardiovascular System; Essential Hypertension; Stress Reactions. Minor Descriptor: Adaptation; Cardiovascular Disorders; Stress. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 52. 
AB  - In our laboratory approximately 1400 tracings have been made on 150 subjects, including subjects with a variety of cardiovascular disturbances and normal subjects. The studies were done with the subject reclining on the ballistocardiographic table. Records were made during quiet breathing for several seconds out of every minute. Immediately before and after each record the arterial pressure was determined by means of a sphygmomanometer cuff wrapped around the left arm. The mean of these readings was used in the calculations. With reference to the relation of arterial pressure to the height of the IJ wave, three contrasting patterns of cardiovascular dynamics were evoked by various stimuli, including muscular effort, immersing the hand in cold water, or interviews concerning pertinent personal problems. It is shown, with appropriate documentation, that hemodynamic changes productive of elevated arterial pressure, reduced renal blood flow and increased blood viscosity occur as a part of an individual's adaptation to problems and challenges in his daily life. Special attention has been directed to two contrasting patterns of hemodynamic adjustment which occur alike in hypertensive and normotensive individuals under stress. One pattern appears to be identical with the 'exercise' pattern in which occurs an increase in blood pressure attributable to a rise in stroke volume without elevation of peripheral vascular resistance. The other pattern resembles that encountered in injury or hemorrhage in which occurs an increase in blood pressure attributable to an elevation in peripheral vascular resistance without a rise in stroke volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hemodynamics
KW  - essential hypertension
KW  - cardiovascular disturbances
KW  - adaptation
KW  - daily life stressors
KW  - stress
KW  - 1955
KW  - Blood Pressure
KW  - Cardiovascular Reactivity
KW  - Cardiovascular System
KW  - Essential Hypertension
KW  - Stress Reactions
KW  - Adaptation
KW  - Cardiovascular Disorders
KW  - Stress
KW  - 1955
DO  - 10.1037/14077-007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-008
AN  - 2009-06034-008
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - A survey of 114 patients with essential hypertension followed up to eight years.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 120
EP  - 204
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-008. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Disease Course; Essential Hypertension; Personality Correlates; Stress Reactions; Symptoms. Minor Descriptor: Cardiovascular Reactivity; Stress; World View. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Followup Study. Page Count: 85. 
AB  - Our survey and follow-up study of 114 patients with essential hypertension is in substantial agreement with other published series. It is the general consensus that it is a disease which begins in the first half-century of life, that there is a predominance of women and that the symptoms, although quite characteristic of the condition, have little to do with either the height of the blood pressure or the rate of arterial or arteriolar degeneration. More striking, it appears that neither the height nor duration of the elevation of arterial pressure provide a reliable indicator of severity or prognosis. Unaccountably some patients lose their evidences of hypertension, even after years of known high blood pressure. Possible explanations for this and considerations of treatment will be presented in the next chapter. A study of personality adjustment among the patients with hypertension did not delineate any characteristic personality 'type', but yielded strikingly similar data as regards values, attitudes and way of life. By and large the hypertensives had grown up feeling the need to excel but at the same time to avoid conflict or too vigorous self-assertion. These strivings, often opposed as they were, led frequently to dilemmas and were manifest by wary, tentative and non-committal attitudes with respect to important interpersonal relations and major endeavors in life. In the present series the 12 per cent of patients who lost all evidences of hypertension appeared to have developed a more confident and relaxed approach to life, a more optimistic outlook, and an improved capacity for self-assertion. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - essential hypertension
KW  - symptoms
KW  - disease course
KW  - personality
KW  - stress
KW  - stress reactions
KW  - world view
KW  - 1955
KW  - Disease Course
KW  - Essential Hypertension
KW  - Personality Correlates
KW  - Stress Reactions
KW  - Symptoms
KW  - Cardiovascular Reactivity
KW  - Stress
KW  - World View
KW  - 1955
DO  - 10.1037/14077-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-009
AN  - 2009-06034-009
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Treatment of essential hypertension.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 205
EP  - 224
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-009. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Essential Hypertension; Treatment Effectiveness Evaluation; Treatment. Minor Descriptor: Adjustment; Attitude Change; Drug Therapy; Emotional States; Exercise; Personality Correlates. Classification: Health Psychology & Medicine (3360). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 20. 
AB  - This chapter considers treatments for hypertension and the difficulties in evaluating this therapy. Although the most widely accepted criterion of success is a sustained lowering of blood pressure, there is no proof that prognosis is actually altered thereby. In fact, there is some evidence, which suggests that differences in level of arterial pressure within the hypertensive range do not correlate with the progress of the disease or the ultimate outcomes. Antipressor drugs and surgical operations on various portions of the sympathoadrenal system have not gone far toward solving the problem of therapy in essential hypertension. Perhaps the most promising therapeutic approach is toward the patient as a whole and his general life adjustment. Even here, however, the results of therapy are only suggestive and it remains to be shown that the pathophysiologic process in essential hypertension can be significantly altered by any currently available measures. It is noteworthy that virtually all treatment programs, diverse as they are and usually enthusiastically reported by their proponents have, as a common denominator, a firm cooperative relationship between the patient and his physician. Vigorous muscular exercise is interdicted by most manuals on the therapy of essential hypertension. Moreover, the data presented in the present chapter indicate that relatively uninhibited expressions of aggression, vicarious or otherwise, may be associated with a lowering of arterial pressure. Therefore it might be reasonable to suggest prescription rather than proscription of vigorous muscular effort in essential hypertension in those patients whose hearts are well compensated and not enlarged. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment
KW  - hypertension
KW  - treatment evaluation
KW  - drug therapy
KW  - exercise
KW  - emotional expression
KW  - life adjustment
KW  - 1955
KW  - Essential Hypertension
KW  - Treatment Effectiveness Evaluation
KW  - Treatment
KW  - Adjustment
KW  - Attitude Change
KW  - Drug Therapy
KW  - Emotional States
KW  - Exercise
KW  - Personality Correlates
KW  - 1955
DO  - 10.1037/14077-009
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-06034-010
AN  - 2009-06034-010
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - General summary and formulation.
T2  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
SP  - 225
EP  - 233
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-010. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Essential Hypertension. Minor Descriptor: Disease Course; Etiology; Personality Correlates; Prognosis; Stress; Stress Reactions; Symptoms. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 9. 
AB  - The major emphasis in the present study has been on the elusive syndrome called essential hypertension. It is recognized at the outset that data bearing on peripheral arterial pressure and pressor mechanisms do not necessarily bear on the processes of vascular degeneration which often accompany sustained elevation of arterial pressure. Elevated arterial pressure has been identified in association with several more or less well understood disturbances in the blood vessels, glands of internal secretion or kidneys, but by far the most frequent instances of sustained blood pressure elevation have been found to occur in the absence of these structural lesions. The common form of hypertension, called essential, has been found to be associated in varying degrees with degenerative changes in the arterioles here and there in the body, but mainly in the kidneys. There is seen, however, no predictable relationship between these changes and the height of the blood pressure or the duration of hypertension. Neither can the course of hypertension nor the likelihood of death from the disease be predicted in the early stages, although in general it has been reliably observed that the more labile the blood pressure, the better the prognosis. It has also been noted that the most overtly 'nervous' patients, who become red-faced during excitement and whose blood pressure falls to normal during sleep, seem to follow the most benign course. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - essential hypertension
KW  - etiology
KW  - disease course
KW  - prognosis
KW  - personality
KW  - stress reactions
KW  - symptoms
KW  - 1955
KW  - Essential Hypertension
KW  - Disease Course
KW  - Etiology
KW  - Personality Correlates
KW  - Prognosis
KW  - Stress
KW  - Stress Reactions
KW  - Symptoms
KW  - 1955
DO  - 10.1037/14077-010
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1955-05395-001
AN  - 1955-05395-001
AU  - Radke-Yarrow, Marian
AU  - Yarrow, Leon J.
T1  - Child psychology.
JF  - Annual Review of Psychology
JO  - Annual Review of Psychology
JA  - Annu Rev Psychol
Y1  - 1955///
VL  - 6
SP  - 1
EP  - 28
CY  - US
PB  - Annual Reviews
SN  - 0066-4308
N1  - Accession Number: 1955-05395-001. PMID: 14377357 Partial author list: First Author & Affiliation: Radke-Yarrow, Marian; National Institute of Mental Health, Bethesda, Md. Release Date: 19550401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 28. Issue Publication Date: 1955. 
AB  - In this review of the literature on child psychology for year ending May, 1954 the authors point out that there is a slowly emerging dynamic point of view in research in this field. The review has the major sections: physical and motor development; learning, perception, and cognitive processes; intellectual development and functioning; personality; psychological problems and disorders; social psychology. 103-item bibliography. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CHILD PSYCHOLOGY
KW  - REVIEW
KW  - BIBLIOGRAPHIES
KW  - PSYCHOLOGY
KW  - CHILD
KW  - CHILDHOOD & ADOLESCENCE
KW  - 1955
KW  - No terms assigned
KW  - 1955
DO  - 10.1146/annurev.ps.06.020155.000245
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-05395-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1956-04459-001
AN  - 1956-04459-001
AU  - Deasy, Leila Calhoun
T1  - An index of social mobility.
JF  - Rural Sociology
JO  - Rural Sociology
JA  - Rural Sociol
Y1  - 1955///
VL  - 20
SP  - 149
EP  - 151
CY  - US
PB  - Rural Sociological Society
SN  - 0036-0112
N1  - Accession Number: 1956-04459-001. Partial author list: First Author & Affiliation: Deasy, Leila Calhoun; National Institutes of Health, Bethesda, Md. Release Date: 19560301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Processes & Social Issues (2900). Page Count: 3. Issue Publication Date: 1955. 
AB  - Movement from one prestige level or 'class' to another was measured by comparing the scores earned by male heads of households with those of their fathers on three factors: occupational (Hatt-North scale), educational (attended college or not), and religious. In the community studied the high prestige denominations were the Episcopal, Congregational and Presbyterian. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - SOCIAL
KW  - MOBILITY
KW  - INDEX OF
KW  - SOCIAL INSTITUTIONS
KW  - 1955
KW  - No terms assigned
KW  - 1955
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1956-04459-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1956-05955-001
AN  - 1956-05955-001
AU  - Lamson, Warren C.
T1  - Integrating mental health services into the community health and welfare program.
JF  - Journal of Psychiatric Social Work
JO  - Journal of Psychiatric Social Work
Y1  - 1955///
VL  - 24
SP  - 244
EP  - 249
N1  - Accession Number: 1956-05955-001. Partial author list: First Author & Affiliation: Lamson, Warren C.; National Institute of Mental Health, Bethesda, Md. Release Date: 19560401. Correction Date: 20151207. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Health. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 6. Issue Publication Date: 1955. 
AB  - Basic principles underlying the integration of mental health services into community health and welfare programs are presented, together with some typical obstacles which can prevent effective integration. In illustration the author describes specific experimental programs in a variety of communities. The authors emphasizes that professional 'experts' should not assume exclusive responsibility or planning for mental health programs. Ultimately the citizens of community must assume this responsibility, with the help of specialists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - PUBLIC
KW  - & MENTAL HEALTH
KW  - MENTAL HEALTH
KW  - IN PUBLIC HEALTH
KW  - CLINICAL PSYCHOLOGY
KW  - GUIDANCE
KW  - COUNSELING
KW  - 1955
KW  - Community Health
KW  - 1955
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1956-05955-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - BOOK
ID  - 2009-06034-000
AN  - 2009-06034-000
AU  - Wolf, Stewart
AU  - Cardon, Phillippe V. Jr.
AU  - Shepard, Edward M.
AU  - Wolff, Harold G.
T1  - Life stress and essential hypertension: A study of circulatory adjustments in man.
Y1  - 1955///
CY  - Baltimore, MD, US
PB  - Williams & Wilkins Co
N1  - Accession Number: 2009-06034-000. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Adaptation; Cardiovascular Reactivity; Cardiovascular System; Essential Hypertension; Stress Reactions. Minor Descriptor: Life Experiences; Stress. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 253. 
AB  - Essential hypertension has proved to be one of the most elusive medical problems of our day. Although the underlying hemodynamic changes are fairly well understood, the mechanisms whereby the changes are brought about and the factors responsible for activating them are still obscure. In view of the oft-heard implications that 'wear and tear' and 'stresses of modern civilization' have something to do with the process, the authors have set out to review the data linking circulatory adjustments to life experiences. In this volume we have tried to pull together into a coherent statement the results of studies on cardiovascular function carried out over the past ten years in the laboratories of Cornell New York Hospital, including a few supplementary observations made in the Department of Medicine at the University of Oklahoma and the Oklahoma Medical Research Foundation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - essential hypertension
KW  - life stress
KW  - circulatory adjustment
KW  - life experiences
KW  - cardiovascular function
KW  - 1955
KW  - Adaptation
KW  - Cardiovascular Reactivity
KW  - Cardiovascular System
KW  - Essential Hypertension
KW  - Stress Reactions
KW  - Life Experiences
KW  - Stress
KW  - 1955
U1  - Sponsor: Public Health Service, National Institutes of Health, National Heart Institute, US. Recipients: No recipient indicated
U1  - Sponsor: Commonwealth Fund. Recipients: No recipient indicated
DO  - 10.1037/14077-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Gentile, Arthur C.
AU  - Klein, Richard M.
T1  - The Apparent Necessity of Indoleacetic Acid for the Growth of Diplodia (Fungi Imperfecti).
JO  - Physiologia Plantarum
JF  - Physiologia Plantarum
Y1  - 1955/04//
VL  - 8
IS  - 2
M3  - Article
SP  - 291
EP  - 299
PB  - Wiley-Blackwell
SN  - 00319317
AB  - Focuses on the results of growth studies on a strain of Diplodia in the presence of 2,4,6 trichlorophenoxyacetic acid (TCPA) or indoleacetic acid (IAA) and combination of these two compounds. Necessity of IAA for the growth of Diploida; Effect of IAA and TCPA on the growth of Diploidia; Implications of the findings of these studies.
KW  - Diplodia
KW  - Plant hormones
KW  - Acetic acid
KW  - Sphaeropsidaceae
KW  - Plant physiology
KW  - Indoleacetic acid
KW  - Plant growth promoting substances
N1  - Accession Number: 15996297; Gentile, Arthur C. 1,2,3; Klein, Richard M. 1,2; Affiliations: 1: Department of Botany, Duke University, Durham, North Carolina; 2: The New Botanical Garden, New York, N. Y.; 3: Public Health Service Research Fellow, National Cancer Institute; Issue Info: 1955, Vol. 8 Issue 2, p291; Thesaurus Term: Diplodia; Thesaurus Term: Plant hormones; Thesaurus Term: Acetic acid; Thesaurus Term: Sphaeropsidaceae; Thesaurus Term: Plant physiology; Subject Term: Indoleacetic acid; Subject Term: Plant growth promoting substances; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15996297&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
AU  - Clausen, John A.
T1  - SOCIAL ISOLATION AND SCHIZOPHRENIA.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1955/06//
VL  - 20
IS  - 3
M3  - Article
SP  - 265
EP  - 273
SN  - 00031224
AB  - Of the several hypotheses relating the frequency of mental disorder to social conditions, none has been more persistently enunciated than that which proposes that schizophrenia is the outgrowth of social isolation. First stated by Faris in 1934, this hypothesis subsequently seemed consistent with and indeed explanatory of the findings of Faris and Dunham's classic ecological study of mental disorder. Faris and Dunham ascertained that high rates of first hospital admissions for schizophrenia are found in areas of the city characterized by high residential mobility and low socio-economic status, among ethnic group persons living in non-ethnic areas, and among the foreign born populations of the slums. All of these indices were regarded as reflecting tendencies toward the social isolation of certain segments of the population. Faris suggested that any form of isolation that cuts the person off from intimate social relations for an extended period of time may possibly lead to this form of mental disorder. More recent statements have suggested that isolation is a result of incongruent intra-familial and extra-familial orientations toward the child and represents a stage in a typical process for schizophrenics.
KW  - SCHIZOPHRENIA
KW  - ETHNIC groups
KW  - MENTAL illness
KW  - SOCIAL participation
KW  - SOCIAL isolation
KW  - SOCIAL status
N1  - Accession Number: 12786754; Kohn, Melvin L. 1; Clausen, John A. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Jun55, Vol. 20 Issue 3, p265; Subject Term: SCHIZOPHRENIA; Subject Term: ETHNIC groups; Subject Term: MENTAL illness; Subject Term: SOCIAL participation; Subject Term: SOCIAL isolation; Subject Term: SOCIAL status; Number of Pages: 9p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12786754&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Gentile, Arthur C.
AU  - Naylor, Aubrey W.
T1  - The Metabolism of Rumex Virus Tumors. Terminal Respiratory enzymes.
JO  - Physiologia Plantarum
JF  - Physiologia Plantarum
Y1  - 1955/07//
VL  - 8
IS  - 3
M3  - Article
SP  - 682
EP  - 690
PB  - Wiley-Blackwell
SN  - 00319317
AB  - A survey was made of the terminal respiratory enzymes in Rumex virus tumor tissue grown in culture. The oxygen uptake of slices of Rumex virus tumors was inhibited about 45 per cent by 0.001 M cyanide. This inhibition suggested the presence of a heavy-metal mediated oxidase system. Cytochrome oxidase. DPNH-linked cytochrome c reductase, and succinic dehydrogenase were found to be present. Catalase and peroxidase activities were also demonstrated. The copper-protein oxidases - polyphenol oxidase, laccase, and ascorbic acid oxidase, were absent in this tissue. Although a residual cyanide respiration suggested the presence of a flavin oxidase, attempts to show glycolic acid dehydrogcnase activity were unsuccessful. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Plant metabolism
KW  - Plant physiology
KW  - Metabolism
KW  - Cytochromes
KW  - Metalloenzymes
KW  - Dehydrogenases
N1  - Accession Number: 15794144; Gentile, Arthur C. 1; Naylor, Aubrey W. 2; Affiliations: 1: Public Health Service Research Fellow of the National Cancer Institute.; 2: Department of Botany, Duke University, Durham, North Carolina.; Issue Info: 1955, Vol. 8 Issue 3, p682; Thesaurus Term: Plant metabolism; Thesaurus Term: Plant physiology; Subject Term: Metabolism; Subject Term: Cytochromes; Subject Term: Metalloenzymes; Subject Term: Dehydrogenases; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1399-3054.ep15794144
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15794144&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2005-10142-018
AN  - 2005-10142-018
AU  - Bayley, Nancy
T1  - Review of Atlas of men.
JF  - Psychological Bulletin
JO  - Psychological Bulletin
JA  - Psychol Bull
Y1  - 1955/07//
VL  - 52
IS  - 4
SP  - 367
EP  - 368
CY  - US
PB  - American Psychological Association
SN  - 0033-2909
SN  - 1939-1455
N1  - Accession Number: 2005-10142-018. Partial author list: First Author & Affiliation: Bayley, Nancy; National Institute of Mental Health, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Human Males; Photographs; Somatotypes. Classification: Personality Psychology (3100). Population: Human (10). Reviewed Item: Sheldon, William H.; Dupertuis, C. Wesley; McDermott, Eugene. Atlas of men=New York: Harper, 1954. Pp. xvi + 357. $10.00; 1954. Page Count: 2. Issue Publication Date: Jul, 1955. Copyright Statement: American Psychological Association. 1955. 
AB  - Reviews the book, Atlas of men by William A. Sheldon (see record [rid]1955-01908-000[/rid]). This book contains somatotype photographs of 1,175 men, selected as representative of the 88 somatotypes identified in the total sample of some 46,000 men ranging in age from 18 to 65 years. As the book is primarily a supplement to the earlier volumes, it is necessary to turn to them for detailed descriptions of the criteria for ratings, unless one can learn, by repeated leafing through the photographs, to identify the differentiating factors between, say, a 2 and a 3 in ectomorphy. For those who are concerned with the problem of physique and its relations to personality and to disease, this book is provocative and a challenge to further research on the hypotheses and assumptions presented. For those who use the Atlas as a tool or guide for evaluating subjects, diligent study of the many illustrations should contribute to proficiency in somatotyping. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - somatotype photographs
KW  - Atlas
KW  - men
KW  - 1955
KW  - Human Males
KW  - Photographs
KW  - Somatotypes
KW  - 1955
U2  - Sheldon, William H.; Dupertuis, C. Wesley; McDermott, Eugene. (1954); Atlas of men; New York: Harper, 1954. Pp. xvi + 357. $10.00
DO  - 10.1037/h0039007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10142-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-001
AN  - 2009-02921-001
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Introduction.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 13
EP  - 15
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-001. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Pathology. Classification: Psychological & Physical Disorders (3200); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - In the present handbook, our scope is less broad. We shall attempt to give a brief, and so far as possible, factual presentation of the major clinical psychiatric problems that the general practitioner and medical student will commonly encounter in hospitals, clinics, and private practice. As much as possible, this book will be organized as are other medical synopses to serve as a convenient easy reference. The major topic headings of the Diagnostic and Statistical Manual of Mental Disorders will be used. Where knowledge exists, the histological, physiological, or chemical pathology of the brain will be described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical psychiatric problems
KW  - pathology
KW  - 1956
KW  - Mental Disorders
KW  - Pathology
KW  - 1956
DO  - 10.1037/13188-001
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-002
AN  - 2009-02921-002
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - History of psychiatric thought.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 16
EP  - 21
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-002. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: History; Mental Disorders; Psychiatry. Classification: History & Systems (2140). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 6. 
AB  - Man has always feared mental illness and the tendency to ascribe its phenomena to supernatural causes is even yet extant. This chapter examines the history of psychiatric thought. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental illness
KW  - history
KW  - psychiatric thought
KW  - 1956
KW  - History
KW  - Mental Disorders
KW  - Psychiatry
KW  - 1956
DO  - 10.1037/13188-002
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-003
AN  - 2009-02921-003
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Examination of the patient.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 22
EP  - 23
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-003. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Patient History. Classification: Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 2. 
AB  - This chapter discusses the purpose of the examination of the patient and its uses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - patient examination
KW  - 1956
KW  - Patient History
KW  - 1956
DO  - 10.1037/13188-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-004
AN  - 2009-02921-004
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The initial psychiatric interview.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 24
EP  - 27
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-004. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychodiagnostic Interview. Minor Descriptor: Mental Disorders; Patients; Psychiatric Evaluation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Interview. Page Count: 4. 
AB  - In psychiatry, therapy and history-taking go hand in hand. Diagnosis and plans for treatment depend upon the results of appraisal of the psychological functioning of the patient. Initial immediate planning, working diagnoses, hospital orders, and instructions to aides and nurses must often be formulated after brief contact with the patient. This initial examination is also known as the 'mental' or 'behavioral status.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - initial examination
KW  - psychological functioning
KW  - behavioral status
KW  - mental status
KW  - psychiatric interview
KW  - 1956
KW  - Psychodiagnostic Interview
KW  - Mental Disorders
KW  - Patients
KW  - Psychiatric Evaluation
KW  - 1956
DO  - 10.1037/13188-004
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-005
AN  - 2009-02921-005
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The complete case study.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 28
EP  - 31
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-005. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Case Report; History; Psychodiagnostic Interview. Minor Descriptor: Psychiatric Evaluation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. 
AB  - The psychiatric case study is completed not from one but from several interviews. In fact, psychotherapeutic interviews extending over many months time are, at least in part, an elaboration and addition to the patient's history. Over the course of such interviews one seeks to characterize the patient in terms of finding repetitive patterns of behavior which frequently associate with significant life events. The stress precipitating a symptom may be in the present or lie in the past. We are not concerned with how 'statistically' abnormal a trait is in the population at large but rather how much does it bother or affect this individual patient. The history obtained from the patient may be unreliable or lacking in detail. Relatives (who should be identified in the chart) may contribute additional history. Friends, employees, school records, etc., can all serve to round out the picture. The following outline presents a form to follow in writing the complete history. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric case study
KW  - complete history
KW  - psychotherapeutic interviews
KW  - 1956
KW  - Case Report
KW  - History
KW  - Psychodiagnostic Interview
KW  - Psychiatric Evaluation
KW  - 1956
DO  - 10.1037/13188-005
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-006
AN  - 2009-02921-006
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - General physical and neurological examination.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 32
EP  - 35
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-006. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Neurology; Physical Examination; Psychiatric Patients. Minor Descriptor: Neuropsychological Assessment. Classification: Clinical Psychological Testing (2224); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. 
AB  - This chapter examines the importance of both the general physical examination and the neurological examination of the psychiatric patient. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurological examination
KW  - physical examination
KW  - psychiatric patient
KW  - 1956
KW  - Neurology
KW  - Physical Examination
KW  - Psychiatric Patients
KW  - Neuropsychological Assessment
KW  - 1956
DO  - 10.1037/13188-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-007
AN  - 2009-02921-007
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The problem of examining the patient for aphasia, agnosia, and apraxia.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 36
EP  - 40
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-007. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Agnosia; Aphasia; Apraxia; Psychiatric Evaluation. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - This chapter discusses the problems of examining patients for aphasia, agnosia, and apraxia. Each of these disorders are described and ways for examining are provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - patient examination
KW  - aphasia
KW  - agnosia
KW  - apraxia
KW  - 1956
KW  - Agnosia
KW  - Aphasia
KW  - Apraxia
KW  - Psychiatric Evaluation
KW  - 1956
DO  - 10.1037/13188-007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-008
AN  - 2009-02921-008
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Electroencephalographic examination.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 41
EP  - 45
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-008. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Electroencephalography; Psychiatric Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - This chapter looks at the use of electroencephalogram in the examination of psychiatric patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric patients
KW  - electroencephalogram
KW  - 1956
KW  - Electroencephalography
KW  - Psychiatric Patients
KW  - 1956
DO  - 10.1037/13188-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-009
AN  - 2009-02921-009
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Psychological examination.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 46
EP  - 61
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-009. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychiatric Patients; Psychological Assessment; Psychological Report. Classification: Clinical Psychological Testing (2224); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16. 
AB  - In the psychiatric team the psychologist may function as a therapist, expert on research design or as a psychological theoretician. His unique contribution to clinical psychiatry, however, lies in the realm of diagnostic testing. In those situations where prolonged observation of the patient is not feasible, or where it is desirable quickly to pick up clues to covert symptomatology, the psychological test battery can be of great value. The psychologist gathers his data from observations of the patient functioning within the framework of a standardized test situation. His battery of psychological tests is carefully planned with a series of specific questions in mind and aimed to assess the patient's assets, conflicts, major defenses against anxiety and amenability to various forms of treatment. The report of psychological findings usually includes a descriptive summary of the patient's personality problems. In order to obtain the greatest value from the psychologist's report, however, the psychiatrist should have some familiarity with the test instruments used. The following section discusses briefly those tests that are commonly included in the diagnostic psychological battery. Some mention is made of their component parts and scoring scales, but for further details the reader is referred to the list of suggested readings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological examination
KW  - psychiatric patients
KW  - diagnostic psychological battery
KW  - 1956
KW  - Psychiatric Patients
KW  - Psychological Assessment
KW  - Psychological Report
KW  - 1956
DO  - 10.1037/13188-009
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-010
AN  - 2009-02921-010
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Psychodynamic concepts of personality development.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 62
EP  - 67
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-010. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Early Experience; Emotional Development; Personality Development; Psychiatric Patients; Psychodynamics. Minor Descriptor: Etiology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 6. 
AB  - In this section will be mentioned briefly a few common concepts which psychiatrists find useful in relating patients' childhood experiences to their adult emotional illnesses. For often it seems clear not only that constitutional factors and immediate life stresses have operated as possible causes but also that the groundwork for later illness was laid in chronically maladaptive attitudes and behaviors unwittingly fostered by the human environment of childhood. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychodynamic concepts
KW  - personality development
KW  - emotional development
KW  - childhood experiences
KW  - psychiatric patients
KW  - 1956
KW  - Early Experience
KW  - Emotional Development
KW  - Personality Development
KW  - Psychiatric Patients
KW  - Psychodynamics
KW  - Etiology
KW  - 1956
DO  - 10.1037/13188-010
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-011
AN  - 2009-02921-011
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The problem of classification.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 68
EP  - 70
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-011. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Psychological Terminology. Minor Descriptor: Psychodiagnostic Typologies. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - The classification of mental disorders is based upon the description of behavioral symptoms and varies over the years with changes in psychologic theory. In the following pages we have sought, where practical, to indicate not only the latest official psychiatric nomenclature but also some of the names popularly used as roughly equivalent terms. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - classification
KW  - mental disorders
KW  - psychiatric nomenclature
KW  - 1956
KW  - Mental Disorders
KW  - Psychological Terminology
KW  - Psychodiagnostic Typologies
KW  - 1956
DO  - 10.1037/13188-011
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-012
AN  - 2009-02921-012
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Standard nomenclature, diseases of the psychobiologic unit as prepared by the Committee on Nomenclature and Statistics of the American Psychiatric Association.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 71
EP  - 75
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-012. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Disorders; Psychobiology; Terminology. Minor Descriptor: Psychiatry. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - This chapter presents standard nomenclature for diseases of the psychobiologic unit as prepared by the Committee on Nomenclature and Statistics of the American Psychiatric Association. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - American Psychiatric Association
KW  - standard nomenclature
KW  - psychobiologic diseases
KW  - 1956
KW  - Disorders
KW  - Psychobiology
KW  - Terminology
KW  - Psychiatry
KW  - 1956
DO  - 10.1037/13188-012
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-013
AN  - 2009-02921-013
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Disorders caused by or associated with impairment of brain tissue function.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 76
EP  - 108
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-013. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Brain Damage. Minor Descriptor: Chronicity (Disorders). Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 33. 
AB  - In this section we will discuss both acute and chronic brain disorders. We would here stress the similarities among the 'toxic' and 'organic' psychoses and point out that although some rather characteristic differences can occur with a specific agent or anatomic predilection of lesion, yet perhaps more striking are the similarities which produce a basic syndrome consisting of: 1. Impairment of orientation. 2. Impairment of intellectual functions including comprehension, calculation, knowledge, learning, judgment, and recent memory. Remote memory is at times preserved. 3. Lability and shallowness of affect. Differences in the clinical picture may occur. Presumably differences in personality structure account for the appearance of such 'types' as paranoid, depressed, manic, etc., listed under individually described psychoses due to widely different agents. The section on delirium discusses the typical reversible, toxic psychoses which may, when the brain damage is severe, likewise progress to an irreversible 'organic syndrome.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - chronic brain disorders
KW  - brain damage
KW  - acute brain disorders
KW  - brain tissue function impairment
KW  - 1956
KW  - Brain Damage
KW  - Chronicity (Disorders)
KW  - 1956
DO  - 10.1037/13188-013
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-014
AN  - 2009-02921-014
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Disorders of psychogenic origin (or without clearly defined physical cause or structural change in the brain).
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 109
EP  - 165
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-014. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Neuroticism; Personality Disorders; Psychosis; Somatoform Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 57. 
AB  - This chapter looks at disorders of psychogenic origin. Four types are discussed including a. psychotic disorders, b. psychoneurotic disorders, c. psychophysiologic autonomic and visceral disorders, and d. personality disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychophysiologic autonomic & visceral disorders
KW  - personality disorders
KW  - psychogenic origin
KW  - psychotic disorders
KW  - psychoneurotic disorders
KW  - 1956
KW  - Neuroticism
KW  - Personality Disorders
KW  - Psychosis
KW  - Somatoform Disorders
KW  - 1956
DO  - 10.1037/13188-014
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-015
AN  - 2009-02921-015
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Mental deficiency.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 166
EP  - 168
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-015. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Intellectual Development Disorder. Minor Descriptor: Treatment. Classification: Mental Retardation (3256); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - This chapter defines and describes various aspects of mental deficiency. Steps in treating mental deficiency are listed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental deficiency
KW  - treatment
KW  - Mental Retardation
KW  - 1956
KW  - Intellectual Development Disorder
KW  - Treatment
KW  - 1956
DO  - 10.1037/13188-015
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-016
AN  - 2009-02921-016
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Child psychiatry.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 169
EP  - 173
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-016. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Child Psychiatry; Mental Disorders. Minor Descriptor: Diagnosis; Etiology; Treatment. Classification: Psychological Disorders (3210). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - Interest in child psychiatry has developed rapidly over the past quarter of a century. The general principles underlying etiology, diagnosis, and therapy of adult psychiatric disorders apply also in child psychiatry. The new specialty of child psychiatry is really a multidisciplined one. While the rationale for treatment grows out of the child's problem, most frequently the child is treated in conjunction with the family or larger social grouping. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child psychiatry
KW  - psychiatric disorders
KW  - treatment
KW  - etiology
KW  - diagnosis
KW  - 1956
KW  - Child Psychiatry
KW  - Mental Disorders
KW  - Diagnosis
KW  - Etiology
KW  - Treatment
KW  - 1956
DO  - 10.1037/13188-016
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-017
AN  - 2009-02921-017
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The psychiatric treatment team.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 174
EP  - 177
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-017. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Interdisciplinary Treatment Approach; Psychiatry. Minor Descriptor: Nurses; Physicians; Psychiatrists; Psychologists; Social Workers. Classification: Health & Mental Health Services (3370); Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. 
AB  - As the multidimensional nature of many illnesses has become clearer, the focus of medical concern has begun to move from treating 'the' illness to treating interacting dysfunctions of related systems either within the patient (biological or physiological) or which impinge upon the patient from without (environmental or social). To employ this complex concept of disease often requires a harmoniously effective team of specialists. This is particularly true in psychiatry where disabling disorders may, in a sense, reside as much within the disturbed relationships surrounding the patient as within the patient himself. Here, therefore, the therapeutic task may involve working in a coordinated manner with several 'patients' as with the patient and his family or with the patient and his employer. Depending upon the setting for treatment, whether state hospital, general hospital, clinic, school or juvenile court, the professional identity of members of the treatment team varies considerably. Thus in a hospital under the supervision of the occupational therapist, a person trained primarily as a musician, artist, or teacher may perform a variety of socializing and ego supportive functions. Within the juvenile court, the probation officer or lawyer may be called upon to perform functions the aims of which do not differ, substantially, from the goals of supportive psychiatric treatment. In medical settings, the primary members of the team may commonly include the psychiatrist, internist (surgeon or pediatrician), social worker, psychologist, and nurse. For special problems the resources available from a mental health oriented minister, dietitian, vocational guidance specialist, marriage counselor, physical therapist, library assistant or a volunteer aide, should be kept in mind. This chapter focuses on the psychiatrist, the collaborating physician, the social worker, the psychologist, and the nurse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social worker
KW  - collaborating physician
KW  - psychiatrist
KW  - psychologists
KW  - nurse
KW  - psychiatric treatment team
KW  - 1956
KW  - Interdisciplinary Treatment Approach
KW  - Psychiatry
KW  - Nurses
KW  - Physicians
KW  - Psychiatrists
KW  - Psychologists
KW  - Social Workers
KW  - 1956
DO  - 10.1037/13188-017
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-018
AN  - 2009-02921-018
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Individual psychotherapy.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 178
EP  - 186
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-018. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Individual Psychotherapy. Minor Descriptor: Psychotherapeutic Processes. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 9. 
AB  - Of the many qualities of different psychotherapeutic relationships, we will present only those common aspects which seem to lend themselves to brief verbal description. Topics discussed in this chapter the task, the place, the time, the doctor, the therapeutic process, the content, the doctor-patient relationship, supervision and consultation, types of therapy, and termination of psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - therapeutic process
KW  - individual psychotherapy
KW  - 1956
KW  - Individual Psychotherapy
KW  - Psychotherapeutic Processes
KW  - 1956
DO  - 10.1037/13188-018
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-019
AN  - 2009-02921-019
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Group therapy.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 187
EP  - 190
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-019. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Group Psychotherapy. Classification: Group & Family Therapy (3313). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. 
AB  - Since ancient times many leaders of men, particularly state or religious leaders, have recognized the power of a unified group in producing certain psychological changes within individual members of the group. Wherever individuals form such a stable group for the purpose of relieving symptoms or strengthening certain personality functions, group therapy may be said to exist. Although some of the qualities of a group and part of the direction in which it proceeds depend upon the personality of the group leader, it is important to recognize that any group has the latent power of self-direction; it may, in one way or another, resist a leader who tries to produce changes which are too divergent from the standards, beliefs or defenses of the members. The effects a group has upon participants' personality or social adjustment seem to be influenced by the tolerance developed within the group for emotional expression, for self scrutiny without loss of self esteem, for attempting corrective emotional experiences, and for identifying or empathizing with each other. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - group therapy
KW  - 1956
KW  - Group Psychotherapy
KW  - 1956
DO  - 10.1037/13188-019
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-020
AN  - 2009-02921-020
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The convulsive therapies.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 191
EP  - 198
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-020. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Electroconvulsive Shock Therapy; Mental Disorders. Minor Descriptor: Seizures. Classification: Specialized Interventions (3350). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. 
AB  - The production of convulsive seizures by pharmacologic means was introduced by von Meduna as a treatment for schizophrenia. Later Cerletti and Bini (1937) introduced the simpler method of electroconvulsive therapy (EST, ECT). The manner in which treatments of this type produce remission from emotional disorder is not understood, but their ability to relieve the symptoms of psychotic depression is universally accepted. Their effectiveness in other psychiatric disorders, however, is still open to question. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric disorders
KW  - convulsive seizures
KW  - electroconvulsive therapy
KW  - convulsive therapies
KW  - 1956
KW  - Electroconvulsive Shock Therapy
KW  - Mental Disorders
KW  - Seizures
KW  - 1956
DO  - 10.1037/13188-020
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-021
AN  - 2009-02921-021
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Insulin therapy.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 199
EP  - 203
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-021. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Insulin Shock Therapy; Psychosis. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - The use of insulin to induce severe hypoglycemic states for the treatment of psychoses was introduced by Manfred Sakel in Vienna in 1933. The term 'insulin shock' refers to the state of vasomotor collapse induced by this method. This chapter looks at the indications, preparatory, contraindications, technique, complications, and results of insulin therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - insulin therapy
KW  - psychoses
KW  - 1956
KW  - Insulin Shock Therapy
KW  - Psychosis
KW  - 1956
DO  - 10.1037/13188-021
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-022
AN  - 2009-02921-022
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Psychosurgery.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 204
EP  - 208
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-022. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Psychosurgery. Classification: Specialized Interventions (3350). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - Techniques of operating upon the human brain for the relief of psychiatric disorder originated from pioneer work of the Swiss psychiatrist Burkhardt (1888), Moniz and Lima of Portugal (1936) and subsequent popularization of the procedure in the United States by Freeman and Watts. Even after almost twenty years and as many thousand operations, however, the subject of lobotomy remains a controversial issue among psychiatrists. In part this stems from the tendency to reserve this brain mutilating procedure for patients who have failed with all other measures of treatment. Naturally the number of 'cures' in such material will not be great. As with other modes of therapy, the best results are obtained if grossly deteriorated patients are avoided and operation is reserved for patients who preserve some evidence of vigorous emotional life. Yet even among chronic backward populations, this procedure combined with an active postoperative program has in some hospitals produced impressive results. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric disorder
KW  - psychosurgery
KW  - 1956
KW  - Mental Disorders
KW  - Psychosurgery
KW  - 1956
DO  - 10.1037/13188-022
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-023
AN  - 2009-02921-023
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Drug therapies.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 209
EP  - 216
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-023. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Drug Therapy; Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. 
AB  - This chapter looks at the use of drug therapies in treating mental disorders. A reference list of drugs and doses having principal effect on CNS is provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental disorders
KW  - drug therapies
KW  - 1956
KW  - Drug Therapy
KW  - Mental Disorders
KW  - 1956
DO  - 10.1037/13188-023
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-024
AN  - 2009-02921-024
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Hydrotherapy.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 217
EP  - 219
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-024. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Treatment. Classification: Specialized Interventions (3350). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - The remedial use of water for mental ills has its origin in the baths of ancient times and is today all too frequently neglected in the hospital management of psychiatric patients. Application may be direct as in tubs, showers, sprays, and douches or by means of compresses or packs. The temperature may be varied as stimulative or sedative effects are desired. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental ills
KW  - hydrotherapy
KW  - 1956
KW  - Mental Disorders
KW  - Treatment
KW  - 1956
DO  - 10.1037/13188-024
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-024&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-025
AN  - 2009-02921-025
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Management of suicidal patients.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 220
EP  - 222
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-025. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychiatric Patients; Suicide; Suicide Prevention; Treatment. Minor Descriptor: Mortality Rate. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - Suicide is the leading cause of death among psychiatric patients. After detailing various suicide statistics, the chapter describes the management of suicidal patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - suicide statistics
KW  - suicidal patients
KW  - suicide management
KW  - 1956
KW  - Psychiatric Patients
KW  - Suicide
KW  - Suicide Prevention
KW  - Treatment
KW  - Mortality Rate
KW  - 1956
DO  - 10.1037/13188-025
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-025&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-026
AN  - 2009-02921-026
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Management of civilian disaster.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 223
EP  - 225
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-026. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Disasters; Emergency Management. Classification: Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - Sudden catastrophes endangering or disrupting the physical world about us take their toll both in injury or death and in emotional disorder. Exposure to unexpected personal danger, to witnessing threatened or actual gruesome damage of loved ones, and experiencing separation from family and friends can tax the strongest personalities. Whether or not disaster produces an acute emotional disorder seems to depend upon a variety of factors. The absence of any prior warning permits no preparatory action and may rob the victim of necessary information to interpret realistically what he experiences. Degree and duration of physical stress, geographical closeness to the area of greatest danger, and previous susceptibility to anxiety apparently influence the likelihood of breakdown. Prophylactic social planning can do much to provide emergency channels of information and to help individuals find their most useful role at the time of disaster. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - catastrophes
KW  - civilian disaster
KW  - social planning
KW  - 1956
KW  - Disasters
KW  - Emergency Management
KW  - 1956
DO  - 10.1037/13188-026
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-027
AN  - 2009-02921-027
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Management of psychiatric problems in the military setting.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 226
EP  - 228
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-027. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Military Personnel. Classification: Psychological Disorders (3210); Military Psychology (3800). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - The role of the psychiatrist in the military setting is structured, defined, and limited by the needs and mission of the Armed Forces. Even more than in civilian practice, the needs of the social group are pre-eminent, whereas the expectations of the individual patient and the physician are secondary. The therapeutic aim, however, is the same; namely, to help the patient to function effectively and comfortably within the current situation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - military setting
KW  - psychiatric problems
KW  - 1956
KW  - Mental Disorders
KW  - Military Personnel
KW  - 1956
DO  - 10.1037/13188-027
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-028
AN  - 2009-02921-028
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - Forensic psychiatry.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 229
EP  - 233
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-028. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Forensic Psychiatry. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - This chapter examines aspects of forensic psychiatry. Topics discussed include commitment procedures, sexual offenses, mental incompetency, and marriage and divorce. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - forensic psychiatry
KW  - 1956
KW  - Forensic Psychiatry
KW  - 1956
DO  - 10.1037/13188-028
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-028&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2009-02921-029
AN  - 2009-02921-029
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - The psychiatrist and mental health.
T2  - A synopsis of contemporary psychiatry.
Y1  - 1956///
SP  - 234
EP  - 236
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-029. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Health; Psychiatrists. Classification: Psychological & Physical Disorders (3200); Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - This chapter examines mental health and the role the psychiatrist. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - psychiatrists
KW  - 1956
KW  - Mental Health
KW  - Psychiatrists
KW  - 1956
DO  - 10.1037/13188-029
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-029&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-21660-008
AN  - 2006-21660-008
AU  - Felix, Robert H.
T1  - The Role of the Federal Government in Mental Health.
T2  - Centennial papers: Saint Elizabeths Hospital 1855-1955.
Y1  - 1956///
SP  - 117
EP  - 126
CY  - Washington, DC, US
PB  - Centennial Commission Saint Elizabeths Hospital
N1  - Accession Number: 2006-21660-008. Partial author list: First Author & Affiliation: Felix, Robert H.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061218. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Government; Government Agencies; Mental Health; Mental Health Programs; Mental Health Services. Minor Descriptor: Government Programs. Classification: Health & Mental Health Treatment & Prevention (3300). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 10. 
AB  - Participation of the federal government in mental health programs covers a broad range of activities, including services to the mentally ill, financial assistance to the states in building mental institutions, and maintenance and support of preventive and control programs. The principal responsibility for the national mental health program is focuses on the National Institute of Mental Health (NIMH). This chapter focuses on the activities and services of NIMH. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - federal government
KW  - US
KW  - mental health
KW  - mental health services
KW  - National Institute of Mental Health
KW  - 1956
KW  - Government
KW  - Government Agencies
KW  - Mental Health
KW  - Mental Health Programs
KW  - Mental Health Services
KW  - Government Programs
KW  - 1956
DO  - 10.1037/11320-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21660-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2005-06680-003
AN  - 2005-06680-003
AU  - Carter, Jerry W. Jr.
ED  - Strother, Charles R.
ED  - Strother, Charles R., (Ed)
T1  - The Training Needs of Psychologists in Community Mental Health Programs at State and Local Levels.
T2  - Psychology and mental health.
Y1  - 1956///
SP  - 21
EP  - 40
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2005-06680-003. Partial author list: First Author & Affiliation: Carter, Jerry W. Jr.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20050718. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Community Mental Health; Mental Health Programs; Postgraduate Training; Psychologists; Psychology Education. Minor Descriptor: Clinical Psychologists; Counseling Psychologists; Needs; Primary Mental Health Prevention; School Psychologists. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 20. 
AB  - Notes that essentially all clinical, counseling, and school psychologists already work in a variety of mental health activities; many other psychologists are engaged in training these and other mental health personnel; and still others do a great deal of the research done on mental health problems. And yet, all these efforts are not enough to satisfy society's needs for more psychologists and more psychological knowledge and skills in mental health programs. In order to better appraise the competencies needed of psychologists in community mental health programs, this chapter reviews the organization and scope of activities in such programs, at state and local levels. The author notes that increased public support--as well as increased federal, state and local funds--for expansion of community mental health activities makes it evident that a greatly increased demand for psychologists to staff these programs will soon be felt. Not only will more clinical, counseling, and school psychologists be needed but the emphasis on preventive mental health programs and on the coordination of community resources necessary to accomplish such programs will require that psychologists be prepared to assume new functions. The author concludes by providing a partial list of suggestions of ways in which training institutions might undertake to develop their staffs for making contributions to the growing field of mental health. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - training needs
KW  - psychologists
KW  - community mental health programs
KW  - state & local levels
KW  - clinical & counseling & school psychologists
KW  - preventive mental health programs
KW  - 1956
KW  - Community Mental Health
KW  - Mental Health Programs
KW  - Postgraduate Training
KW  - Psychologists
KW  - Psychology Education
KW  - Clinical Psychologists
KW  - Counseling Psychologists
KW  - Needs
KW  - Primary Mental Health Prevention
KW  - School Psychologists
KW  - 1956
DO  - 10.1037/10791-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06680-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - BOOK
ID  - 1956-08164-000
AN  - 1956-08164-000
AU  - Clausen, John A.
T1  - Sociology and the field of mental health.
Y1  - 1956///
CY  - New York, NY, US
PB  - Russell Sage Foundation
N1  - Accession Number: 1956-08164-000. Partial author list: First Author & Affiliation: Clausen, John A.; National Institute of Mental Health, Bethesda, Md. Release Date: 19560601. Publication Type: Book (0200). Format Covered: Print. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 62. 
AB  - Some of the present and potential contributions of social science to research and program operations in the mental health field are delineated. Such areas as 'mental health and illness in cultural perspective' and 'research on social and cultural influences' are reviewed. In addition, a broad overview of sociological research brings to our attention the values to be found in such techniques as public opinion surveys designed to bring to light public knowledge and attitudes toward mental health and illness, various applied researches now going on in mental hospitals, and evaluation studies as applied to treatment, control and prevention. Studies in the social structure and function of treatment settings, as well as the effect of mental illness on the patient and his family, are similarly pointed up. 98-item bibliography. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - SOCIOLOGY
KW  - & MENTAL HEALTH
KW  - MENTAL HEALTH
KW  - & SOCIOLOGY
KW  - BIBLIOGRAPHIES
KW  - MENTAL
KW  - SOCIAL PSYCHOLOGY
KW  - 1956
KW  - No terms assigned
KW  - 1956
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1956-08164-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - BOOK
ID  - 2009-02921-000
AN  - 2009-02921-000
AU  - Ulett, George A.
AU  - Goodrich, D. Wells
T1  - A synopsis of contemporary psychiatry.
Y1  - 1956///
CY  - St Louis, MO, US
PB  - C V Mosby Co
N1  - Accession Number: 2009-02921-000. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychiatry. Minor Descriptor: Diagnosis; Syndromes; Treatment. Classification: Psychological & Physical Disorders (3200); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 243. 
AB  - This handbook was written to fill the need for a brief, introductory text of psychiatry as a quick reference for psychiatric residents, medical and psychological interns, medical students, nurses, and others whose work in the psychiatric clinic and hospital may be for a brief period of time. The psychiatric house officer who will spend several years training in the field is called upon in the first weeks of his residency both to diagnose and to treat. This handbook is designed to serve as a ready reference during this initial period of specialty training and until he has had sufficient time to become acquainted with more extensive treatises. With these workers in mind, the book has been made small enough to fit in the side pocket of the clinic coat. It has been written also for the general practitioner who is having his attention increasingly directed to the psychological problems of his patients and who must, in view of the shortage of psychiatrists, often provide early care for those of his patients who develop mental illness. In this text theory is kept to a minimum. The material is organized into three general areas: (a) history taking and diagnostic procedures; (b) clinical syndromes; and (c) therapeutic measures. In the Table of Contents, which follows immediately, one who is unfamiliar with the field can find the general area of his interest at the moment, and then focus upon the page or two devoted to material with which he is specifically concerned. In addition, an alphabetized general index is provided at the end of the book. All sections have been made as brief as possible. We have tried throughout to present the eclectic approach to psychiatry that has been fostered through the teachings of Dr. Edwin F. Gildea. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatry
KW  - diagnostic procedures
KW  - clinical syndromes
KW  - therapeutic measures
KW  - 1956
KW  - Psychiatry
KW  - Diagnosis
KW  - Syndromes
KW  - Treatment
KW  - 1956
DO  - 10.1037/13188-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Adams, Scott
T1  - INFORMATION - A NATIONAL RESOURCE.
JO  - American Documentation
JF  - American Documentation
Y1  - 1956/04//
VL  - 7
IS  - 2
M3  - Article
SP  - 71
EP  - 75
SN  - 0096946X
AB  - Focuses on information resources.  Observation on information resources; Definitions of scientific information; Views of documentalists on information resources; Association of information resources with natural resources; Suggestions for organized documentation.
KW  - INFORMATION resources
KW  - INFORMATION science
KW  - DOCUMENTATION
KW  - NATURAL resources
N1  - Accession Number: 16810762; Adams, Scott 1; Affiliations: 1: Librarian, National Institutes of Health, Public Health Service, U. S. Dept. of Health, Education, and Welfare; Issue Info: Apr1956, Vol. 7 Issue 2, p71; Thesaurus Term: INFORMATION resources; Thesaurus Term: INFORMATION science; Thesaurus Term: DOCUMENTATION; Subject Term: NATURAL resources; Number of Pages: 5p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16810762&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
AU  - Williams Jr., Robin M.
T1  - SITUATIONAL PATTERNING IN INTERGROUP RELATIONS.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1956/04//
VL  - 21
IS  - 2
M3  - Article
SP  - 164
EP  - 174
SN  - 00031224
AB  - There is now abundant research evidence of situational variability in intergroup behavior: an ever-accumulating body of research demonstrates that allegedly prejudiced persons act in a thoroughly egalitarian manner in situations where that is the socially prescribed mode of behavior, and that allegedly unprejudiced persons discriminate in situations where they feel it is socially appropriate to do so. It is also well known that patterns of "appropriateness" in intergroup behavior have been changing with increasing tempo in recent years. The unthinkable of a short time ago has in many areas of life become the commonplace of today. For a brief period the transition from unthinkable to commonplace arouses extreme emotional fervor; but as the new definition of the situation becomes the socially prescribed, the fervor soon diminishes. Unpatterned situations, in which definitions of appropriate conduct are in process of change, occur infrequently, and it is even more infrequent that they occur at the convenience of the research observer.
KW  - INTERGROUP relations
KW  - INTERPERSONAL relations
KW  - SOCIAL interaction
KW  - EQUALITY
KW  - SOCIAL attitudes
KW  - SOCIAL science research
N1  - Accession Number: 12786264; Kohn, Melvin L. 1; Williams Jr., Robin M. 2; Affiliations: 1: National Institute of Mental Health; 2: Cornell University; Issue Info: Apr56, Vol. 21 Issue 2, p164; Thesaurus Term: INTERGROUP relations; Thesaurus Term: INTERPERSONAL relations; Subject Term: SOCIAL interaction; Subject Term: EQUALITY; Subject Term: SOCIAL attitudes; Subject Term: SOCIAL science research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 11p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12786264&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Deasy, Leila Calhoun
T1  - SOCIO-ECONOMIC STATUS AND PARTICIPATION IN THE POLIOMYELITIS VACCINE TRIAL.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1956/04//
VL  - 21
IS  - 2
M3  - Article
SP  - 185
EP  - 191
SN  - 00031224
AB  - The relationships between socio-economic status and orientations toward values such as health, cleanliness, and education have been observed in a large number of community studies and attitude surveys by social scientists. Recently attention has been directed to the effect of socio-economic status on types of treatment sought for various illnesses. Independently, practitioners in the field of public health have learned to make reasonably accurate predictions of the amount of co-operation community health programs will receive from various segments of the local population. In general, they seem to anticipate that preventive programs will encounter the greatest opposition in the strata of lower socio-economic status, except where specific vested interests of other groups are involved. An opportunity to analyze responses to a new program which offered the possibility of giving protection against poliomyelitis was provided in the spring of 1954 when the National Foundation for Infantile Paralysis sponsored a large-scale trial of the poliomyelitis vaccine developed by Jonas Salk. The effectiveness of the vaccine could be determined only by its administration to large numbers of people. The vaccine was offered to children in certain grades in selected areas throughout the U. S., on condition that their parents approve their participation.
KW  - POLIO -- Vaccination
KW  - HEALTH promotion
KW  - PUBLIC health
KW  - ENTEROVIRUS diseases
KW  - SOCIAL scientists
KW  - SALK, Jonas, 1914-1995
N1  - Accession Number: 12786267; Deasy, Leila Calhoun 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Apr56, Vol. 21 Issue 2, p185; Subject Term: POLIO -- Vaccination; Subject Term: HEALTH promotion; Subject Term: PUBLIC health; Subject Term: ENTEROVIRUS diseases; Subject Term: SOCIAL scientists; NAICS/Industry Codes: 525120 Health and Welfare Funds; People: SALK, Jonas, 1914-1995; Number of Pages: 7p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12786267&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2013-40817-010
AN  - 2013-40817-010
AU  - Kohn, Melvin L.
AU  - Clausen, John A.
T1  - Parental authority behavior and schizophrenia.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1956/04//
VL  - 26
IS  - 2
SP  - 297
EP  - 313
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40817-010. PMID: 13313699 Partial author list: First Author & Affiliation: Kohn, Melvin L.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Parent Child Relations; Parental Characteristics; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Apr, 1956. 
AB  - The present paper reports data secured from systematic interviewing of a sample of schizophrenic patients and former patients from a single community, along with data on carefully selected controls for these patients. In addition to our interest in the perception or recollection of parent-child relationships, we have been concerned with social participation or isolation during adolescence, social and residential mobility, and other experiences in the childhood and adolescence of the patients and controls. Our inquiry into family relationships is limited in scope to the two dimensions on which previous investigators have reached the most consistent confusions-authority and affection. Our techniques for eliciting data were simple and, by clinical standards, extremely crude. Despite this crudeness, however, the complementality of our findings to those of investigators who have secured their data from the mothers of schizophrenic patients, and the interrelationships that we have found between social status and the perception of family structure, lead us to hope that presentation of these data will be of value to others seeking to carry out research on this complex problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - parental authority behavior
KW  - schizophrenia
KW  - parent-child relationships
KW  - communities
KW  - interrelationships
KW  - 1956
KW  - Communities
KW  - Parent Child Relations
KW  - Parental Characteristics
KW  - Schizophrenia
KW  - 1956
DO  - 10.1111/j.1939-0025.1956.tb06179.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40817-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Deasy, Leila Calhoun
T1  - Health, Culture and Community: Case Studies of Public Reactions to Health Programs (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1956/06//
VL  - 21
IS  - 3
M3  - Book Review
SP  - 395
EP  - 395
SN  - 00031224
AB  - Reviews the book "Health, Culture and Community: Case Studies of Public Reactions to Health Programs," edited by Benjamin D. Paul and Walter B. Miller.
KW  - PUBLIC health
KW  - NONFICTION
KW  - PAUL, Benjamin D.
KW  - MILLER, Walter B.
KW  - HEALTH, Culture & Community: Case Studies of Public Reactions to Health Programs (Book)
N1  - Accession Number: 12772474; Deasy, Leila Calhoun 1; Affiliations: 1: National institute of Mental Health; Issue Info: Jun56, Vol. 21 Issue 3, p395; Subject Term: PUBLIC health; Subject Term: NONFICTION; Reviews & Products: HEALTH, Culture & Community: Case Studies of Public Reactions to Health Programs (Book); NAICS/Industry Codes: 525120 Health and Welfare Funds; People: PAUL, Benjamin D.; People: MILLER, Walter B.; Number of Pages: 2/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 
TY  - 
AU  - Bayley, Nancy1
AU  - Findley, Warren C.2
AU  - Gerberich, J. Raymond3
AU  - Justman, Joseph4
AU  - Mollenkopf, William G.2
AU  - Sells, Saul B.5
AU  - Stroud, James B.6
AU  - Swineford, Frances2
AU  - Symonds, Percival M.7
AU  - Wrightstone, J. Wayne8
T1  - Educational Measurements.
JO  - Review of Educational Research
JF  - Review of Educational Research
J1  - Review of Educational Research
PY  - 1956/06//
Y1  - 1956/06//
VL  - 26
IS  - 3
CP  - 3
M3  - Article
SP  - 268
EP  - 291
SN  - 00346543
AB  - This article presents the contributions of research to tests and measurements in the area of intelligence, aptitude, achievement, personality, interests and attitudes, interests and attitudes, child study technics, and statistical methods related to test construction. Experimentation directed toward applications peculiar to nonverbal tests, in general school practice. It also recognizes verbal group tests influenced by reading proficiency. Understanding of the nature and structure of human abilities.
KW  - Reading
KW  - Educational tests & measurements
KW  - Child development -- Research
KW  - Ability
KW  - Personality
KW  - Child development
KW  - Comprehension
N1  - Accession Number: 18812127; Authors: Bayley, Nancy 1; Findley, Warren C. 2; Gerberich, J. Raymond 3; Justman, Joseph 4; Mollenkopf, William G. 2; Sells, Saul B. 5; Stroud, James B. 6; Swineford, Frances 2; Symonds, Percival M. 7; Wrightstone, J. Wayne 8; Affiliations:  1: National Institute of Mental Health, Bethesda, Maryland;  2: Educational Testing Service, Princeton, New Jersey;  3: University of Connecticut, Storrs, Connecticut;  4: Board of Education, New York, New York;  5: U.S.A.F. School of Aviation Medicine, Randolph Air Force Base, San Antonio, Texas;  6: State University of Iowa, Iowa City, Iowa;  7: Teachers College, Columbia University, New York, New York;  8: Chairman, Board of Education, New York, New York; Subject: Educational tests & measurements; Subject: Child development -- Research; Subject: Ability; Subject: Personality; Subject: Child development; Subject: Comprehension; Subject: Reading; Number of Pages: 24p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
ID  - 2012-23199-004
AN  - 2012-23199-004
AU  - Clausen, John A.
AU  - Linn, Erwin L.
T1  - Public reaction to a severe polio outbreak in three Massachusetts communities.
JF  - Social Problems
JO  - Social Problems
JA  - Soc Probl
Y1  - 1956/07//
VL  - 4
IS  - 1
SP  - 40
EP  - 51
CY  - US
PB  - University of California Press
SN  - 0037-7791
SN  - 1533-8533
N1  - Accession Number: 2012-23199-004. Partial author list: First Author & Affiliation: Clausen, John A.; Laboratory of Socio-environmental Studies, National Institute of Mental Health, MD, US. Other Publishers: Oxford University Press. Release Date: 20130617. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Epidemics; Public Opinion; Society; Urban Environments. Minor Descriptor: Poliomyelitis. Classification: Social Processes & Social Issues (2900). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jul, 1956. 
AB  - This article presents a study which aims to examine the reactions of the public to a severe polio outbreak in three Massachusetts communities. The respondents of the study were asked how one can tell when a disease has reached an epidemic stage. The data which have been presented bear on two aspects of response to the threat of a polio epidemic in three separate communities within an urban area, communications about the disease threat and appropriate actions toward it, as carried in the local press, and individual perceptions, attitudes and actions relative to that threat on the part of the mothers of young children. The study concluded that the effectiveness of any society's efforts to cope with disease or threats to health clearly depends not only on the availability of scientific knowledge underlying techniques of treatment and of disease control, but also upon the readiness of the population to utilize such knowledge. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - polio
KW  - epidemics
KW  - urban areas
KW  - social efforts
KW  - public reactions
KW  - communities
KW  - 1956
KW  - Communities
KW  - Epidemics
KW  - Public Opinion
KW  - Society
KW  - Urban Environments
KW  - Poliomyelitis
KW  - 1956
U1  - Sponsor: Committee on Disaster Studies. Recipients: No recipient indicated
DO  - 10.2307/798566
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2012-23199-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05944-021
AN  - 2006-05944-021
AU  - Kendig, Isabelle V.
T1  - An Adolescent Topsy.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1956/08//
VL  - 1
IS  - 8
SP  - 246
EP  - 246
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05944-021. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kendig, Isabelle V.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Community Mental Health; Community Services. Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: Kotinsky, Ruth (Ed); Witmer, Helen L. (Ed). Community Programs for Mental Health=Cambridge, Mass.: Harvard University Press, 1955. Pp. xix + 362. $5.00; 1955. Page Count: 1. Issue Publication Date: Aug, 1956. 
AB  - Reviews the book, Community Programs for Mental Health edited by Ruth Kotinsky and Helen L. Witmer (see record [rid]1956-04525-000[/rid]). This collection of papers is best understood in historical perspective. The present volume reflects the remarkable development of the mental health movement, as it is now termed, since that first decade. It is most hopeful that the mental health movement has now achieved that degree of self-awareness that inspires its leaders to seek to clarify its fundamental tenets and practices. The half dozen papers presented here raise, however, many questions and offer few answers. The cause of mental illness is still insufficiently understood, there is no generally accepted definition of mental health, and no 'core curriculum' of principles upon which to base action. While the symposium as a whole will prove thought-provoking to the layman interested in mental health, its challenge is to professional workers responsible for shaping and directing this lusty, adolescent movement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health movement
KW  - adolescent movement
KW  - community programs
KW  - mental health
KW  - 1956
KW  - Adolescent Development
KW  - Community Mental Health
KW  - Community Services
KW  - 1956
U2  - Kotinsky, Ruth (Ed); Witmer, Helen L. (Ed). (1955); Community Programs for Mental Health; Cambridge, Mass.: Harvard University Press, 1955. Pp. xix + 362. $5.00
DO  - 10.1037/005399
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05944-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05946-011
AN  - 2006-05946-011
AU  - Kelman, Herbert C.
T1  - Empathy Is Not Enough.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1956/10//
VL  - 1
IS  - 10
SP  - 299
EP  - 300
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05946-011. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kelman, Herbert C.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Empathy; Family Relations; Personality Development; Social Skills; Interpersonal Relationships. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Foote, Nelson N.; Cottrell, Leonard S. Jr. Identity and Interpersonal Competence: A New Direction in Family Research=Chicago: University of Chicago Press, 1955. Pp. ix + 305. $5.00; 1955. Page Count: 2. Issue Publication Date: Oct, 1956. 
AB  - Reviews the book, Identity and Interpersonal Competence: A New Direction in Family Research by Nelson N. Foote and Leonard S. Cottrell, Jr. (see record [rid]1956-02753-000[/rid]). The bulk of the book is devoted to the development of three interrelated sets of criteria: (1) criteria for evaluating personality development in family members, (2) criteria for evaluating family agencies (and families) in terms of their readiness to undertake deliberate, planned programs designed to enhance personality development, and (3) criteria for evaluating research programs in terms of the likelihood that they will produce results that are generalizable and usable by families and agencies The desirability of democratic planning in the operations of individuals, agencies, and research programs is the common thread that runs through all three of these sets of criteria. The authors' central concept for personality development is interpersonal competence. They list six components of interpersonal competence-health, intelligence, empathy, autonomy, judgment, and creativity-all of which are viewed as capacities needed by the individual for effective handling of his interpersonal relations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - personality development
KW  - family agencies
KW  - interpersonal relations
KW  - interpersonal competence
KW  - health
KW  - 1956
KW  - Empathy
KW  - Family Relations
KW  - Personality Development
KW  - Social Skills
KW  - Interpersonal Relationships
KW  - 1956
U2  - Foote, Nelson N.; Cottrell, Leonard S. Jr. (1955); Identity and Interpersonal Competence: A New Direction in Family Research; Chicago: University of Chicago Press, 1955. Pp. ix + 305. $5.00
DO  - 10.1037/005436
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05946-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Shock, Nathan W.
T1  - Age changes in some physiologic processes.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1957/01//
VL  - 12
IS  - 1
M3  - Article
SP  - 40
EP  - 48
SN  - 0016867X
N1  - Accession Number: 17414914; Shock, Nathan W. 1,2; Source Information: Jan1957, Vol. 12 Issue 1, p40; Number of Pages: 9p; Illustrations: 15 Graphs; Document Type: Article; Full Text Word Count: 3952
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2013-39110-005
AN  - 2013-39110-005
AU  - Gordon, Gene
AU  - Siegel, Leonard
T1  - The evolution of a program of individual psychotherapy for children with aggressive acting-out disorders in a new residential treatment unit.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1957/01//
VL  - 27
IS  - 1
SP  - 59
EP  - 68
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39110-005. PMID: 13402870 Partial author list: First Author & Affiliation: Gordon, Gene; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Acting Out; Antisocial Behavior; Individual Psychotherapy; Residential Care Institutions; Treatment Duration. Minor Descriptor: Aggressive Behavior; Patients. Classification: Behavior Disorders & Antisocial Behavior (3230); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Page Count: 10. Issue Publication Date: Jan, 1957. 
AB  - This article provides an overview of a program of individual psychotherapy for children with aggressive acting-out disorders in a new residential treatment unit of the Program of Individual Psychotherapy in the Laboratory of Child Research at the National Institutes of Health. This Laboratory was organized to investigate the residential treatment of children with aggressive acting-out disorders. Toward the end of the third month, the authors admitted the first patient group of five boys ranging in age from 9 to 13.5. These boys were selected for study from other institutions where they had been admitted for such complaints as fire-setting, vandalism, stealing, truancy, and severe temper tantrums and planned to keep them at least three months and no longer than eight months. The impact of this first disturbed group was profound. The second patient group was composed of the three youngest boys from the first patient group and three new patients. This second group ranged in age from 9 to 12-in contrast to the first group which ranged from 9 to 13.5. The patients in this second group had manifested much the same kind of antisocial behavior as their predecessors. The third patient group differ from the earlier patient groups in two important respects. The children were younger ranging in age from 8 through 10 and with this group, the authors commited themselves to long-term treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aggressive acting-out disorders
KW  - antisocial behavior
KW  - long term treatment
KW  - patient groups
KW  - residential treatment
KW  - individual psychotherapy
KW  - 1957
KW  - Acting Out
KW  - Antisocial Behavior
KW  - Individual Psychotherapy
KW  - Residential Care Institutions
KW  - Treatment Duration
KW  - Aggressive Behavior
KW  - Patients
KW  - 1957
DO  - 10.1111/j.1939-0025.1957.tb05200.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39110-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39110-006
AN  - 2013-39110-006
AU  - Bloch, Donald A.
AU  - Silber, Earle
T1  - The role of the administrator in relation to individual psychotherapy in a residential treatment setting.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1957/01//
VL  - 27
IS  - 1
SP  - 69
EP  - 74
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39110-006. PMID: 13402871 Partial author list: First Author & Affiliation: Bloch, Donald A.; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a Session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Individual Psychotherapy; Residential Care Institutions; Role Playing; Health Personnel. Minor Descriptor: Intensive Care. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 6. Issue Publication Date: Jan, 1957. 
AB  - This article discusses the role of the administrator in relation to individual psychotherapy in a residential treatment setting. The article focus on his role as it bears on a program of intensive individual psychotherapy carried on concurrently with the milieu treatment. The administrator performs the initial psychiatric examination and participates in the child’s preadmission visits to the living unit. He has an opportunity in these contacts to communicate the broad outlines of his functions as well as those of other significant people. Moreover, he continues the process, already begun by the referring agency, of defining with the child the problem areas in his living which have led to his institutionalization. With regard to individual psychotherapy, certain features of the administrator’s role may be emphasized. In part because of his authoritative position, and in part because he functions as the psychiatrist in the intake interview, he becomes, from the very first moment, in the eyes of the child, the responsible sponsor of treatment. That is, he defines problem areas and initiates a corrective regimen. This includes the sponsorship of individual psychotherapy. The administrator’s specific functions in the treatment process are derived from his unique position in the social structure of the residential setting. His position as a key person in the policy making and communication network on the unit and as an authority figure in the child’s life can be used therapeutically in combining milieu therapy with intensive individual psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - residential treatment setting
KW  - milieu therapy
KW  - intensive individual psychotherapy
KW  - administrator roles
KW  - 1957
KW  - Individual Psychotherapy
KW  - Residential Care Institutions
KW  - Role Playing
KW  - Health Personnel
KW  - Intensive Care
KW  - 1957
DO  - 10.1111/j.1939-0025.1957.tb05201.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39110-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-03890-001
AN  - 1959-03890-001
AU  - Ader, Robert
AU  - Clink, Daniel W.
T1  - Effects of chlorpromazine on the acquisition and extinction of an avoidance response in the rat.
JF  - The Journal of Pharmacology and Experimental Therapeutics
JO  - The Journal of Pharmacology and Experimental Therapeutics
JA  - J Pharmacol Exp Ther
Y1  - 1957///
VL  - 121
SP  - 144
EP  - 148
CY  - US
PB  - American Society for Pharmacology & Experimental Therapeutics ASPET
SN  - 0022-3565
SN  - 1521-0103
N1  - Accession Number: 1959-03890-001. PMID: 13481837 Other Journal Title: Pharmacological Reviews. Partial author list: First Author & Affiliation: Ader, Robert; National Institutes of Health. Release Date: 19590201. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 5. Issue Publication Date: 1957. 
AB  - Rats receiving 1.5 or 3.0 mgm/kgm chlorpromazine were compared with saline controls for acquisition and extinction of avoidance in a modified Miller-Mowrer shuttlebox. The chlorpromazine animals required significantly more trials than the controls to meet the criterion for avoidance. 'Without regard for the conditions under which the response was acquired, chlorpromazine (1.5 mgm/kgm) decreased resistance to extinction. Whereas there were no differences in comparable groups under the smaller dosage, 3.0 mgm/kgm of chlorpromazine decreased the resistance of animals having acquired the response under placebo.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - EXTINCTION
KW  - AVOIDANCE
KW  - RESPONSE
KW  - RAT
KW  - DRUGS
KW  - CHLORPROMAZINE
KW  - AVOIDANCE LEARNING
KW  - CHLORPROMAZINE &
KW  - TREATMENT METHODS
KW  - 1957
KW  - No terms assigned
KW  - 1957
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-05927-001
AN  - 1959-05927-001
AU  - Hollister, William G.
T1  - The risks of freedom-giving group leadership.
JF  - Mental Hygiene. New York
JO  - Mental Hygiene. New York
Y1  - 1957///
VL  - 41
SP  - 238
EP  - 244
N1  - Accession Number: 1959-05927-001. PMID: 13418332 Partial author list: First Author & Affiliation: Hollister, William G.; National Institute of Mental Health, Bethesda, Md. Release Date: 19590301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 7. Issue Publication Date: 1957. 
AB  - Leadership is not without its hazards, especially in dynamic group activities. Some of these hazards are delineated and discussed. The values in the leadership role are great regardless of the fact that its risks are manifold. The leader gains his profits from knowledge of the behavioral-patterns of the component elements of the group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - LEADERSHIP
KW  - HAZARDS & GAINS OF
KW  - SOCIAL PSYCHOLOGY
KW  - 1957
KW  - No terms assigned
KW  - 1957
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-01281-001
AN  - 1959-01281-001
AU  - Kataguchi, Yasufumi
T1  - The development of the Rorschach test in Japan.
JF  - Journal of Projective Techniques
JO  - Journal of Projective Techniques
Y1  - 1957///
VL  - 21
SP  - 258
EP  - 260
N1  - Accession Number: 1959-01281-001. PMID: 13463809 Partial author list: First Author & Affiliation: Kataguchi, Yasufumi; National Institute of Mental Health, Japan. Release Date: 19590101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 3. Issue Publication Date: 1957. 
AB  - The writer reviews the history of the Rorschach in Japan, showing the number of papers on the Rorschach that have been read each year since 1950 at the Japanese Psychological Association. Also presented are complete bibliographies of Japanese books and articles on the Rorschach. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - RORSCHACH TEST
KW  - JAPAN
KW  - CULTURES
KW  - BIBLIOGRAPHIES
KW  - RORSCHACH IN JAPAN
KW  - DIAGNOSIS & EVALUATION
KW  - 1957
KW  - No terms assigned
KW  - 1957
DO  - 10.1080/08853126.1957.10380781
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-01281-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-00495-001
AN  - 1959-00495-001
AU  - Botwinick, Jack
AU  - Jerome, Edward A.
AU  - Birren, James E.
AU  - Brinley, Joseph F.
T1  - Light aversion motivation in psychologic studies of aging in rats.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1957///
VL  - 12
SP  - 296
EP  - 299
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1959-00495-001. PMID: 13463300 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Botwinick, Jack; National Institute of Mental Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19590101. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 4. Issue Publication Date: 1957. 
AB  - For aging studies of rat behavior, a technique was tested for its suitability. Two groups of Sprague-Dawley rats of approximately 1 and 2 years of age were statistically similar with respect to several criteria of averting light. It was concluded that the technique 'is suitable for age comparisons in rat learning, at least within the age period of 1 or 2 years.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - RAT
KW  - HOODED
KW  - AGING STUDY
KW  - LIGHT AVERSION TECHNIQUE
KW  - AVOIDANCE LEARNING
KW  - AGE OF RAT
KW  - AGE
KW  - AVOIDANCE LEARNING &
KW  - RESPONSE PROCESSES
KW  - 1957
KW  - No terms assigned
KW  - 1957
DO  - 10.1093/geronj/12.3.296
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00495-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-00924-001
AN  - 1959-00924-001
AU  - Botwinick, Jack
AU  - Brinley, Joseph F.
AU  - Birren, James E.
T1  - Set in relation to age.
JF  - Journal of Gerontology
JO  - Journal of Gerontology
JA  - J Gerontol
Y1  - 1957///
VL  - 12
SP  - 300
EP  - 305
CY  - US
PB  - Gerontological Society of America
SN  - 0022-1422
N1  - Accession Number: 1959-00924-001. PMID: 13463301 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Botwinick, Jack; National Institute of Mental Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19590101. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 6. Issue Publication Date: 1957. 
AB  - Two age groups were compared with respect to set as it is defined by the functional relation between reaction time and an irregularly presented series of preparatory intervals. The largest age differences in reaction time were with the shortest or shorter intervals. This suggested that the older group either required more time for preparation or required more time to overcome the effects of an overestimated interval. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - SET
KW  - & AGE
KW  - AGE
KW  - & SET IN REACTION TIME
KW  - MATURITY & OLD AGE
KW  - 1957
KW  - No terms assigned
KW  - 1957
DO  - 10.1093/geronj/12.3.300
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00924-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-03929-001
AN  - 1959-03929-001
AU  - Day, Juliana
T1  - The role and reaction of the psychiatrist in LSD therapy.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1957///
VL  - 125
SP  - 437
EP  - 437
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
N1  - Accession Number: 1959-03929-001. PMID: 13481751 Partial author list: First Author & Affiliation: Day, Juliana; National Institute of Mental Health. Release Date: 19590201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 1. Issue Publication Date: 1957. 
AB  - Observations on 2 borderline neurotics, who received LSD from the therapist, convince her that LSD sets in motion certain processes within the patient which are out of the therapist's and the patient's control. While this drug is given in order to establish a better therapeutic relationship, its secondary effects can defeat the very purpose for which it was administered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - PSYCHOTHERAPY
KW  - LYSERGIC ACID
KW  - IN NEUROSIS
KW  - NEUROSIS
KW  - & PSYCHOTHERAPY ON
KW  - DRUGS
KW  - DIETHYLAMIDE
KW  - TREATMENT METHODS
KW  - 1957
KW  - No terms assigned
KW  - 1957
DO  - 10.1097/00005053-195707000-00016
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-03929-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-01643-001
AN  - 1959-01643-001
AU  - Kramer, Morton
AU  - Person, Philip H. Jr.
AU  - Tarjan, George
AU  - Morgan, Richard
AU  - Wright, Stanley W.
T1  - A method for determination of probabilities of stay, release, and death, for patients admitted to a hospital for the mentally deficient: The experience of Pacific State Hospital during the period 1948-1952.
JF  - American Journal of Mental Deficiency
JO  - American Journal of Mental Deficiency
JA  - Am J Ment Defic
Y1  - 1957///
VL  - 62
SP  - 481
EP  - 495
CY  - US
PB  - American Assn on Mental Retardation
SN  - 0002-9351
N1  - Accession Number: 1959-01643-001. PMID: 13469851 Other Journal Title: American Journal on Intellectual and Developmental Disabilities; American Journal on Mental Retardation. Partial author list: First Author & Affiliation: Kramer, Morton; National Institute of Mental Health, Public Health Service, Bethesda, Md. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19590101. Correction Date: 20101213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 15. Issue Publication Date: 1957. 
AB  - A series of analyses is presented demonstrating 'a method for determining the probability of release, death and retention for patients admitted to a hospital for the mentally retarded.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MENTAL RETARDATION
KW  - HOSPITAL STAY
KW  - ANALYSIS
KW  - HOSPITAL
KW  - FOR MENTAL DEFECTIVES
KW  - RETENTION PROBABILITY
KW  - MENTAL DEFICIENCY
KW  - 1957
KW  - No terms assigned
KW  - 1957
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-01643-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-00538-001
AN  - 1959-00538-001
AU  - Mirsky, Allan F.
AU  - Rosvold, H. Enger
AU  - Pribram, Karl H.
T1  - Effects of cingulectomy on social behavior in monkeys.
JF  - Journal of Neurophysiology
JO  - Journal of Neurophysiology
JA  - J Neurophysiol
Y1  - 1957///
VL  - 20
SP  - 588
EP  - 601
CY  - US
PB  - American Physiological Society
SN  - 0022-3077
SN  - 1522-1598
N1  - Accession Number: 1959-00538-001. PMID: 13476215 Partial author list: First Author & Affiliation: Mirsky, Allan F.; National Institute of Mental Health, Bethesda, Maryland. Release Date: 19590101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 14. Issue Publication Date: 1957. 
AB  - 'Bilateral cingular gyrus ablations were performed in five young Macaca mulatta monkeys, after systematic observations of their behavior in response to man (individual-cage situation) and to other animals in a social colony (group-cage situation).' The change in behavior following the ablation is described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - SOCIAL BEHAVIOR
KW  - & CINGULECTOMY
KW  - MONKEY
KW  - CINGULECTOMY
KW  - & SOCIAL BEHAVIOR
KW  - CINGULATE GYRUS
KW  - LESION IN
KW  - BEHAVIOR &
KW  - RESPONSE PROCESSES
KW  - 1957
KW  - No terms assigned
KW  - 1957
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00538-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-00250-001
AN  - 1959-00250-001
AU  - Mishkin, Mortimer
T1  - Effects of small frontal lesions on delayed alternation in monkeys.
JF  - Journal of Neurophysiology
JO  - Journal of Neurophysiology
JA  - J Neurophysiol
Y1  - 1957///
VL  - 20
SP  - 615
EP  - 622
CY  - US
PB  - American Physiological Society
SN  - 0022-3077
SN  - 1522-1598
N1  - Accession Number: 1959-00250-001. PMID: 13476217 Partial author list: First Author & Affiliation: Mishkin, Mortimer; National Institute of Mental Health, Bethesda, Md. Release Date: 19590101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Physiological Psychology & Neuroscience (2500). Page Count: 8. Issue Publication Date: 1957. 
AB  - 'To help define the cortical area focally concerned in delayed-response types of functions in the monkey, ten animals were given various subtotal lesions of frontal granular cortex and tested for the retention of a delayed-alternation habit. The four animals that received lesions of the midlateral cortex performed more poorly than the animals with other lesions. In one instance a midlateral lesion produced a deficit that was as severe and as longlasting as that following total anterior frontal ablation. The results are discussed in relation to possible neural mechanisms for the mediation of delayed-responses in the monkey.' 20 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MONKEY
KW  - BRAIN LESION
KW  - & DELAYED RESPONSE
KW  - DELAYED RESPONSE &
KW  - NERVOUS SYSTEM
KW  - 1957
KW  - No terms assigned
KW  - 1957
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00250-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-00494-001
AN  - 1959-00494-001
AU  - Blough, Donald S.
T1  - Spectral sensitivity in the pigeon.
JF  - Journal of the Optical Society of America
JO  - Journal of the Optical Society of America
JA  - J Opt Soc Am
Y1  - 1957///
VL  - 47
SP  - 827
EP  - 833
CY  - US
PB  - Optical Society of America
SN  - 0030-3941
N1  - Accession Number: 1959-00494-001. PMID: 13463678 Other Journal Title: Journal of the Optical Society of America, A, Optics, Image & Science; Journal of the Optical Society of America, A, Optics, Image Science & Vision. Partial author list: First Author & Affiliation: Blough, Donald S.; National Institute of Mental Health, National Institutes of Health, Bethesda, Md. Release Date: 19590101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 7. Issue Publication Date: 1957. 
AB  - 'Measurements of light- and dark-adapted absolute thresholds were obtained from three pigeons at 15 wavelengths ranging from 380 mμ to 700mμ. Pecking responses caused a stimulus patch to fluctuate in intensity up and down across the pigeon's threshold, and a record of the intensity provided the sensitivity data. The sensitivity of the birds was followed throughout a period of 80 min. following a standard pre-exposure to white light. Four complete dark adaptation curves were obtained from each bird at each wavelength. Spectral sensitivity functions derived from these curves place the photopic maximum at 560-580 mμ, and the scotopic maximum at about 500 mμ. The scotopic function is fitted closely by aphakic human data. The photopic function shows inflections that may be related to similar inflections in corresponding human curves. The functions are quite similar to those found in electrophysiological studies of the pigeon eye. They also correspond rather well to the absorption spectra of chicken rhodopsin and iodopsin.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - PIGEON
KW  - SPECTRAL SENSITIVITY
KW  - LIGHT ADAPTATION
KW  - IN PIGEON
KW  - DARK ADAPTATION
KW  - RESPONSE PROCESSES
KW  - VISION
KW  - 1957
KW  - No terms assigned
KW  - 1957
DO  - 10.1364/JOSA.47.000827
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00494-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Perry, Stewart E.
T1  - Integrating Sociological and Psychoanalytic Concepts: An Exploration in Child Psychotherapy (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1957/02//
VL  - 22
IS  - 1
M3  - Book Review
SP  - 113
EP  - 114
SN  - 00031224
AB  - Reviews the book "Integrating Sociological and Psychoanalytic Concepts: An Exploration in Child Psychotherapy," by Otto Pollak.
KW  - CHILD psychotherapy
KW  - NONFICTION
KW  - POLLAK, Otto
KW  - INTEGRATING Sociological & Psychoanalytic Concepts: An Exploration in Child Psychotherapy (Book)
N1  - Accession Number: 12771427; Perry, Stewart E. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Feb57, Vol. 22 Issue 1, p113; Subject Term: CHILD psychotherapy; Subject Term: NONFICTION; Reviews & Products: INTEGRATING Sociological & Psychoanalytic Concepts: An Exploration in Child Psychotherapy (Book); People: POLLAK, Otto; Number of Pages: 2p; Document Type: Book Review
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12771427&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-05951-019
AN  - 2006-05951-019
AU  - Birren, James E.
T1  - Aging Comes of Age.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1957/03//
VL  - 2
IS  - 3
SP  - 82
EP  - 82
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05951-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Birren, James E.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Gerontology; Human Development; Physiological Aging. Classification: Gerontology (2860). Population: Human (10). Reviewed Item: Anderson, John E. (Ed). Psychological Aspects of Aging=(Proceedings of a Conference on Planning Research, Bethesda, Md., 24-27 April 1955.) Washington, D. C: American Psychological Association, 1956. Pp. viii + 323. $2.00; 1956. Page Count: 1. Issue Publication Date: Mar, 1957. 
AB  - Reviews the book, Psychological Aspects of Aging by John E. Anderson (Ed.) (1956). This book will answer the question' 'What is the psychology of aging?' It is the only existing comprehensive summary of the literature and research issues, and its publication in such a usable form is a creditable achievement. One gathers from the present proceedings that many of the participants regarded the study of aging as one of the vantage points from which a scientist may operate in exploring the organization of function. The presence in the conference of persons who had done most of their research in the field of child development is significant. The many questions raised by this conference are relevant to the practical problems of older people. Certainly a service has been done for science by the present conference that asks what we know and do not know about aging and then puts the discussion into print. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological aspects
KW  - aging
KW  - older people
KW  - human development
KW  - 1957
KW  - Gerontology
KW  - Human Development
KW  - Physiological Aging
KW  - 1957
U2  - Anderson, John E. (Ed). (1956); Psychological Aspects of Aging; (Proceedings of a Conference on Planning Research, Bethesda, Md., 24-27 April 1955.) Washington, D. C: American Psychological Association, 1956. Pp. viii + 323. $2.00
DO  - 10.1037/005499
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05951-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05952-016
AN  - 2006-05952-016
AU  - Hill, Harris E.
T1  - How to Help the Addict.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1957/04//
VL  - 2
IS  - 4
SP  - 113
EP  - 114
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05952-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hill, Harris E.; National Institute of Mental Health, Lexington, KY, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinics; Drug Addiction; Drug Rehabilitation; Narcotic Drugs. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Nyswander, Marie. The Drug Addict as a Patient=New York: Grune & Stratton, 1956. Pp. xi + 179. $4.50; 1956. Page Count: 2. Issue Publication Date: Apr, 1957. 
AB  - Reviews the book, The Drug Addict as a Patient by Marie Nyswander (see record [rid]1956-08359-000[/rid]). The author presents a well-written account of published findings and personal opinions that covers many disciplines. Author presents it in a style which is sufficiently popular to attract both layman and physician. Addiction is here characterized as a 'distinct medical entity' which is 'pandemic.' The author's arguments for a reconsideration of the addict's plight and for devising better methods for his rehabilitation present the strongest, if not the most valid, part of the book. Tone, purpose, and fact are well blended here to depict narcotic addicts as persons who are terribly misunderstood and mistreated, and who should be maintained on drugs dispensed by government clinics while their rehabilitation is attempted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - narcotic addicts
KW  - rehabilitation
KW  - drug abuse
KW  - government clinics
KW  - 1957
KW  - Clinics
KW  - Drug Addiction
KW  - Drug Rehabilitation
KW  - Narcotic Drugs
KW  - 1957
U2  - Nyswander, Marie. (1956); The Drug Addict as a Patient; New York: Grune & Stratton, 1956. Pp. xi + 179. $4.50
DO  - 10.1037/005515
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05952-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39302-014
AN  - 2013-39302-014
AU  - Kaplan, David M.
AU  - Goodrich, D. Wells
T1  - A formulation for interpersonal anger.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1957/04//
VL  - 27
IS  - 2
SP  - 387
EP  - 395
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39302-014. PMID: 13424647 Partial author list: First Author & Affiliation: Kaplan, David M.; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a Session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Acting Out; Aggressive Behavior; Anger; Emotions; Interpersonal Interaction. Minor Descriptor: Responses. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Apr, 1957. 
AB  - This article presents a systematic way by which interpersonal anger is studied. The data was gathered on the immediate precipitating factors leading to the expression of anger, on the nature and psychological meaning of anger in these interactions and on any distinctive aspects of these anger interactions which relate to the problems of the aggressive acting-out child. The objective in analyzing these interactions was to formulate psychologically meaningful descriptions which would include the subjective aspects of the individual participant’s experience in these interactions. An analysis of this anger response suggests that it consists of four conceptually separate phases or parts: cognitive, physiological, emotional, and conative. From a theoretical point of view anger is not conceived here simply as an emotion or a feeling experience alone. It is a complex that includes cognitive, emotional, physiological, and conative processes, all of which are intimately interwoven and inseparable from one another. Anger does not occur as an invariant response to frustration but depends upon the individual’s interpretation of the behavior of others. Once anger does occur, the interpretation is made implicitly that the behavior of the other is intentionally and unjustifiably hostile and the other is held accountable for his actions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aggressive child acting out
KW  - anger interactions
KW  - anger response
KW  - conative processes
KW  - feeling experience
KW  - interpersonal anger
KW  - 1957
KW  - Acting Out
KW  - Aggressive Behavior
KW  - Anger
KW  - Emotions
KW  - Interpersonal Interaction
KW  - Responses
KW  - 1957
DO  - 10.1111/j.1939-0025.1957.tb05502.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39302-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39302-015
AN  - 2013-39302-015
AU  - Siegel, Leonard
T1  - Case study of a thirteen-year-old fire-setter: A catalyst in the growing pains of a residential treatment unit.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1957/04//
VL  - 27
IS  - 2
SP  - 396
EP  - 410
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39302-015. Partial author list: First Author & Affiliation: Siegel, Leonard; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a Session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Antisocial Behavior; Behavior Disorders; Residential Care Institutions; Treatment Facilities. Classification: Behavior Disorders & Antisocial Behavior (3230); Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Inpatient (50). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Clinical Case Study. References Available: Y. Page Count: 15. Issue Publication Date: Apr, 1957. 
AB  - This article presents a case report of a 13-year old boy Freddy, who had been picked up by the police for setting fires. He toured the neighborhood with the fire marshals and with little reluctance pointed out the places where he had set several dozen small fires The mother, weakly supported by the father, fought every step in the subsequent legal preliminaries to residential treatment of the child. The lengthy court trials with cross-examinations of the psychiatrists in the presence of the child and his parents, a prolonged stay in the overcrowded detention home, and a period of observation on the adult ward of a psychiatric hospital seemed to aid in cementing the bonds of the pre-existent ambivalent alliance between the patient and his mother. The data available on admission indicated that fire-setting was only one aspect of a broad spectrum of disturbed behavior which included a life history of soiling, several episodes of running away, difficulties in school, truancy, nightmares, and temper tantrums. Freddy was treated by utilizing the therapeutic technique of playroom psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - residential treatment
KW  - treatment units
KW  - behavior disorders
KW  - antisocial behavior
KW  - 1957
KW  - Antisocial Behavior
KW  - Behavior Disorders
KW  - Residential Care Institutions
KW  - Treatment Facilities
KW  - 1957
DO  - 10.1111/j.1939-0025.1957.tb05503.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39302-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05953-005
AN  - 2006-05953-005
AU  - Dittmann, Allen T.
T1  - Sullivan's Two Premises.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1957/05//
VL  - 2
IS  - 5
SP  - 127
EP  - 129
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05953-005. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Dittmann, Allen T.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Diagnosis; Mental Disorders; Psychiatry; Symptoms. Minor Descriptor: Philosophies. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Sullivan, Harry Stack; Perry, Helen Swick (Ed); Gawel, Mary Ladd (Ed); Gibbon, Martha (Ed). Clinical Studies in Psychiatry=New York: W. W. Norton, 1956. Pp. xiv + 386. $5.50; 1956. Page Count: 3. Issue Publication Date: May, 1957. 
AB  - Reviews the book, Clinical Studies in Psychiatry by Helen Swick Perry (Ed.), Mary Ladd Gawel, and Martha Gibbon (see record [rid]1956-07384-000[/rid]). This book is most informative in demonstrating the practical effects of Sullivan's theoretical contributions. Like many books called 'clinical psychiatry,' the first half deals with 'symptoms,' how to recognize them and what they mean, and the second takes up the diagnostic entities. Viewed as an advanced text in psychiatry (his audience had already had considerable training), the book is confusingly titled. It contains no 'studies' but is rather a statement of a very experienced and independently thinking psychiatrist's clinical philosophy. In another sense the book is really a text on schizophrenia. Though nicely turned and perhaps appealing to a lecture audience, they require extra work of the reading audience. One could say that Sullivan's philosophy has become psychiatric currency and that the publication of these old lectures serves little purpose. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical studies
KW  - psychiatry
KW  - mental disorders
KW  - symptoms
KW  - diagnosis
KW  - Sullivans philosophy
KW  - 1957
KW  - Clinical Psychology
KW  - Diagnosis
KW  - Mental Disorders
KW  - Psychiatry
KW  - Symptoms
KW  - Philosophies
KW  - 1957
U2  - Sullivan, Harry Stack; Perry, Helen Swick (Ed); Gawel, Mary Ladd (Ed); Gibbon, Martha (Ed). (1956); Clinical Studies in Psychiatry; New York: W. W. Norton, 1956. Pp. xiv + 386. $5.50
DO  - 10.1037/005635
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05953-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39298-021
AN  - 2013-39298-021
AU  - Kramer, Morton
T1  - Concepts in establishing mental health clinic reporting: Workshop report.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1957/07//
VL  - 27
IS  - 3
SP  - 643
EP  - 645
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39298-021. PMID: 13444453 Partial author list: First Author & Affiliation: Kramer, Morton; Biometrics Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Concept Formation; Data Collection; Psychiatric Clinics. Minor Descriptor: Mental Health; Population. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 3. Issue Publication Date: Jul, 1957. 
AB  - The primary workshop objective was the review of needs and goals of data collection from mental health clinics at clinic, city, state and national levels and how the current reporting program is meeting these needs. The author outlined briefly the background of the national clinic reporting program and stated as its goal the collection of some basic facts on the outpatient psychiatric clinic population and clinic services. The author pointed out some of the problems in data collection due to the large number and variety of clinics in the country and the complexity of services provided. The author also emphasized the selective nature of the clinic population and that care must be exercised in drawing conclusions on the characteristics of the entire mentally ill population from a study of psychiatric clinic and mental hospital patients only. Of prime importance in the conceptualization of a mental health clinic reporting program is the recognition of some differences between needs for statistical information at clinic or worker levels and at city, state and national levels. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health clinics
KW  - data collection
KW  - conceptualization
KW  - psychiatric clinic populations
KW  - 1957
KW  - Concept Formation
KW  - Data Collection
KW  - Psychiatric Clinics
KW  - Mental Health
KW  - Population
KW  - 1957
DO  - 10.1111/j.1939-0025.1957.tb05529.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39298-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-02996-001
AN  - 1959-02996-001
AU  - Rheingold, Harriet L.
AU  - Hess, Eckhard H.
T1  - The chick's 'preference' for some visual properties of water.
JF  - Journal of Comparative and Physiological Psychology
JO  - Journal of Comparative and Physiological Psychology
JA  - J Comp Physiol Psychol
Y1  - 1957/10//
VL  - 50
IS  - 5
SP  - 417
EP  - 421
CY  - US
PB  - American Psychological Association
SN  - 0021-9940
N1  - Accession Number: 1959-02996-001. PMID: 13481175 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Rheingold, Harriet L.; National Institute of Mental Health. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 19590201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Preferences; Visual Perception. Minor Descriptor: Chickens; Water Intake. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 1957. Copyright Statement: American Psychological Association. 1957. 
AB  - At 3 days of age 2 groups of chicks were tested for preference when an array of 6 substances was presented. One group had no prior experience with food or water, while the other had been given them from birth. The distribution of responses by both groups was similar, the order of preference being: mercury, plastic, blue water, water, metal, and red water. 'Although no clear evidence of the propotency of any of the visual attributes of water was demonstrated, it seems probable that attractiveness to the chick lies in a combination of a bright reflecting surface and the movement of the stimulus.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - visual properties
KW  - visual attributes
KW  - chicks
KW  - water
KW  - 1957
KW  - Preferences
KW  - Visual Perception
KW  - Chickens
KW  - Water Intake
KW  - 1957
DO  - 10.1037/h0046108
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-02996-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - NEWS
AU  - Hunt, G. Halsey
T1  - The key role of the physician in geriatric research.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1957/11//
VL  - 12
IS  - 11
M3  - Editorial
SP  - 679
EP  - 681
SN  - 0016867X
N1  - Accession Number: 17775882; Hunt, G. Halsey 1; Source Information: Nov1957, Vol. 12 Issue 11, p679; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1637
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17775882&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2006-05957-019
AN  - 2006-05957-019
AU  - Kendig, Isabelle V.
T1  - The Un-Merry Widow.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1957/11//
VL  - 2
IS  - 11
SP  - 290
EP  - 291
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05957-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kendig, Isabelle V.; National Institute of Mental Health, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adjustment; Counselors; Marriage; Widows. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Langer, Marion. Learning to Live as a Widow=New York: Julian Messner, 1957. Pp. 255. $3.95; 1957. Page Count: 2. Issue Publication Date: Nov, 1957. 
AB  - Reviews the book, Learning to Live as a Widow by Marion Langer (see record [rid]1957-04558-000[/rid]). The curious thing about this book is that its counterpart, Learning to Live as a Widower, is unlikely ever to be written. Yet the problems dealt with here could as appropriately be treated from the correlative point of view with perhaps two exceptions-Handling the Purse Strings and You as a 'Working Man.' Otherwise, the grief experienced in the loss of a wife and the necessity to deal with the deep feelings aroused, the later need for meeting eligible, single women and, finally, for remarriage are fundamentally the same. Dr. Langer discusses is the widow's feeling of inferiority in practically all situations but especially in those involving normal, social interactions and work adjustment. In general, however, the author's prescription for widows, as for any emotionally disturbed person, is psychologically sound. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - widows
KW  - marriage counselors
KW  - marriage
KW  - 1957
KW  - Adjustment
KW  - Counselors
KW  - Marriage
KW  - Widows
KW  - 1957
U2  - Langer, Marion. (1957); Learning to Live as a Widow; New York: Julian Messner, 1957. Pp. 255. $3.95
DO  - 10.1037/005676
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05957-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - Gen
ID  - 9999-28527-000
AN  - 9999-28527-000
AU  - Schaefer, Earl S.
AU  - Bell, Richard Q.
T1  - Parental Attitude Research Instrument
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1958///
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-28527-000. Other Names: Inventory of Attitudes on Family Life and Children. Acronyms: PARI. Partial author list: First Author & Affiliation: Schaefer, Earl S.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20150413. Instrument Type: Inventory/Questionnaire. Test Format: Each of the 115 statements on the Parental Attitude Research Instrument is rated on a 4-point scale: A = strongly agree, a = mildly agree, d = mildly disagree, D = strongly disagree.. Language: English. Constructs: Parental Attitudes; Classification: Family Relationships and Parenting (6100). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Parental Attitude Research Instrument is to reveal parental attitudes toward family life and child rearing as reported by mothers.
AB  - Description: The 115-item Parental Attitude Research Instrument (PARI; Schaefer & Bell, 1958) is an attitude questionnaire completed by mothers to reveal parental attitudes toward family life and child rearing. This measure was developed based on theories of parental influence upon development of children and a review of previous research on the relationship of parental attitudes to the personality adjustment of children. A set of 32 concepts were selected which were derived from previous studies (Mark, 1953; Shoben, 1949) and from a search of the literature on parent-child relationships. Attitude scales of 5-10 items which gave satisfactory reliability for research purposes were developed with an iterative technique of attitude measurement. Item and reliability analyses resulted in the final form, which consists of 23 five-item scales. All items (e.g., 'A good mother should shelter her child from life's little difficulties' and 'Strict discipline develops a fine strong character') are rated on a 4-point scale: A = strongly agree, a = mildly agree, d = mildly disagree, D = strongly disagree. In samples of samples of multiparae and primiparae, internal consistency reliability coefficients were satisfactory. Three-month test-retest reliabilities were generally good although a few scales on which there was very little variability in score had appreciably lower test-retest reliability as compared to internal consistency reliability. The studies surveyed in the review of literature could be cited as evidence supporting the concurrent validity of this general approach to the study of parent-child relationships. The content validity or the adequacy of the concepts of parental attitudes toward child-rearing can be determined by attempting to add concepts which would add new variance to measurement of this domain. Adequate evidence of the construct validity of these scales must be based upon research on various correlates of these measures. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Parental Attitude Research Instrument
KW  - Mothers
KW  - Test Development
KW  - Internal Consistency
KW  - Test-Retest Reliability
KW  - Concurrent Validity
KW  - Child Rearing Attitudes
KW  - Family Life
U5  - Parental Attitude Research Instrument (PARI) [Test Development]Development of a Parental Attitude Research Instrument. (AN: 1960-01417-001 from PsycINFO) Schaefer, Earl S.; Bell, Richard Q.; Sep, 1958. Source: Child Development. 29, Blackwell Publishing, United Kingdom; Sep, 1958; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs); Population: Human; Female; Location: US; Sample: Multiparae; Primiparae Keywords: Parental Attitude Research Instrument; Mothers; Test Development; Internal Consistency; Test-Retest Reliability; Concurrent Validity; Child Rearing Attitudes; Family Life; Subjects: Attitude Measures; Childrearing Attitudes; Family Relations; Inventories; Mothers; Parental Attitudes; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t28527-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-28527-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - CHAP
ID  - 2006-10211-003
AN  - 2006-10211-003
AU  - Evarts, Edward V.
ED  - Rinkel, Max
ED  - Rinkel, Max, (Ed)
T1  - Chemical Basis for Psychosis: Neuropharmacological Contributions to Our Present Concept.
T2  - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957.
Y1  - 1958///
SP  - 41
EP  - 62
CY  - New York, NY, US
PB  - McDowell, Obolensky
N1  - Accession Number: 2006-10211-003. Partial author list: First Author & Affiliation: Evarts, Edward V.; National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Behavior; Electrophysiology; Lysergic Acid Diethylamide; Neurology; Pharmacology. Minor Descriptor: Biochemistry; Bufotenine; Cats; Experimental Psychosis; Experimentation; Monkeys; Psychiatry; Psychosis; Serotonin. Classification: Psychopharmacology (2580); Schizophrenia & Psychotic States (3213). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22. 
AB  - Within recent years three discoveries have led to increased prominence of psychotomimetic agents as research tools in experimental psychiatry. These three discoveries were: first, the demonstration of the remarkable psychological actions and potency of d-lysergic acid diethylamide (LSD); second, the isolation and chemical identification of 5-hydroxytryptamine (5-HT) (10, 30); and third, the demonstration that LSD is a potent antagonist of 5-HT in vitro (19, 41). In this chapter neuropharmacological studies in animals on the basis of these three fundamental discoveries are summarized, and as the result of these studies speculations about a chemical basis for psychosis in humans are offered. The experiments were begun in an attempt to gain further knowledge about those behavioral and electrophysiological effects of LSD which might be relevant to an explanation of the effects of LSD on psychological processes in man. The hypothesis of Gaddum (20) and of Woolley and Shaw (41, 42) that the actions of LSD were related to its interaction with 5-HT served as a point of departure. One approach to obtaining further knowledge of the mechanism of action of LSD was to examine the effects of other substances whose actions might also be related to an interaction with 5-HT. One such obvious source is the class of structural congeners of 5-HT, and therefore a series of experiments was started with a small group of tryptamine and LSD derivatives. It was the purpose of these experiments to obtain information concerning the degree to which analogues of 5-HT might produce neuropharmacological effects which corresponded to those of the LSD. The first 5-HT congener which we studied was bufotenine, the N-dimethyl derivative of 5-HT. The investigations of the actions of bufotenine were undertaken on the basis of the theoretical considerations and as the result of Stromberg's (37) discovery that bufotenine is the principal alkaloid of cohoba (33), which the natives of Haiti used as a stimulating snuff. The possibility that bufotenine was the active agent in cohoba, and, therefore, a psychotomimetic agent, made the studies of its neuropharmacological actions of particular interest. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - chemical basis for psychosis
KW  - monkeys
KW  - neuropharmacological studies
KW  - cats
KW  - LSD
KW  - 5-HT
KW  - experimental psychiatry
KW  - behavior
KW  - bufotenine
KW  - electrophysiology
KW  - 1958
KW  - Behavior
KW  - Electrophysiology
KW  - Lysergic Acid Diethylamide
KW  - Neurology
KW  - Pharmacology
KW  - Biochemistry
KW  - Bufotenine
KW  - Cats
KW  - Experimental Psychosis
KW  - Experimentation
KW  - Monkeys
KW  - Psychiatry
KW  - Psychosis
KW  - Serotonin
KW  - 1958
DO  - 10.1037/11190-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-10211-015
AN  - 2006-10211-015
AU  - Brodie, Bernard B.
AU  - Bogdanski, Donald F.
AU  - Shore, Parkhurst A.
ED  - Rinkel, Max
ED  - Rinkel, Max, (Ed)
T1  - Serotonin in Relation to Brain Function: III. The Action of Psychotropic Drugs (A Biochemical and Physiological Interpretation).
T2  - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957.
Y1  - 1958///
SP  - 190
EP  - 203
CY  - New York, NY, US
PB  - McDowell, Obolensky
N1  - Accession Number: 2006-10211-015. Partial author list: First Author & Affiliation: Brodie, Bernard B.; Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Brain; Drugs; Parasympathetic Nervous System; Pharmacology; Sympathetic Nervous System. Minor Descriptor: Biochemistry; Norepinephrine; Physiology; Serotonin; Theories. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 14. 
AB  - The theory is presented that the autonomic, somatic and psychic functions of the body are maintained in a balanced state by two opposing systems, the trophotropic and ergotropic, and that these systems have receptor sites that are modulated by serotonin and norepinephrine, respectively. A number of drugs may be classified and their mechanism of action described according to their effects on the trophotropic or ergotropic systems. In considering the following views, it must be borne in mind that since the two subcortical brain systems are antagonistic, it should be possible to produce the same syndrome by stimulating one system or by depressing the other. Accordingly, the following possibilities present themselves: A) A drug may produce the trophotropic syndrome by activation of the trophotropic system or by depression of the ergotropic system. B) A drug may produce the ergotropic syndrome by blocking the trophotropic system (thus unmasking the ergotropic) or by directly stimulating the ergotropic system. C) A drug may affect the diencephalic integrative mechanisms by blocking monoamine oxidase. D) A drug may block the synthesis of serotonin or norepinephrine. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - subcortical brain systems
KW  - serotonin
KW  - psychic functions
KW  - ergotropic system
KW  - theory
KW  - autonomic functions
KW  - psychotrophic drug action
KW  - trophotropic system
KW  - norepinephrine
KW  - somatic functions
KW  - 1958
KW  - Brain
KW  - Drugs
KW  - Parasympathetic Nervous System
KW  - Pharmacology
KW  - Sympathetic Nervous System
KW  - Biochemistry
KW  - Norepinephrine
KW  - Physiology
KW  - Serotonin
KW  - Theories
KW  - 1958
DO  - 10.1037/11190-015
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-10211-019
AN  - 2006-10211-019
AU  - McDonald, Roger K.
ED  - Rinkel, Max
ED  - Rinkel, Max, (Ed)
T1  - Experimental Studies with Fluids Obtained from Psychotic Patients: II. Ceruloplasmin and Schizophrenia.
T2  - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957.
Y1  - 1958///
SP  - 230
EP  - 237
CY  - New York, NY, US
PB  - McDowell, Obolensky
N1  - Accession Number: 2006-10211-019. Partial author list: First Author & Affiliation: McDonald, Roger K.; Section on Medicine, Laboratory of Clinical Science, National Institute of Mental Health, U. S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Ascorbic Acid; Biochemistry; Blood Proteins; Enzymes; Schizophrenia. Minor Descriptor: Blood Plasma; Physiological Correlates. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 8. 
AB  - Early in 1957 Akerfeldt (4, 5) reported his experience with a simple blood test for mental disease. This test consists of adding an aromatic dye, N-N-dimethylparaphenylenediamine (DPP), to serum and measuring the intensity of the red color which developed over a period of six minutes. Akerfeldt noted that DPP was converted to its oxidized form, Wurster's red, more rapidly by the sera from schizophrenic patients than by the sera from normal controls. Akerfeldt concluded that the differences in the dye reaction between schizophrenic and normal control sera were due to the low ascorbic acid concentration and high ceruloplasmin concentration in schizophrenic serum. The contribution of Akerfeldt was re-emphasizing findings of serum abnormalities in schizophrenia previously reported, and devising a simple test in which the two assumed abnormalities serve as primary determinants. During the past year McDonald, Weise, Patrick and Evans have conducted investigations on chronic schizophrenic patients and control subjects, matched for age and sex. Because the plasma ascorbic acid and ceruloplasmin concentrations are primarily involved in Akerfeldt's test, these parameters were assessed concomitantly with the dye oxidation curves. The results are summarized. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - ascorbic acid concentrations
KW  - schizophrenic patients
KW  - ceruloplasmin concentrations
KW  - plasma
KW  - physiological correlates
KW  - 1958
KW  - Ascorbic Acid
KW  - Biochemistry
KW  - Blood Proteins
KW  - Enzymes
KW  - Schizophrenia
KW  - Blood Plasma
KW  - Physiological Correlates
KW  - 1958
DO  - 10.1037/11190-019
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-07701-001
AN  - 1959-07701-001
AU  - Blough, Donald S.
T1  - A method for obtaining psychophysical thresholds from the pigeon.
JF  - Journal of the Experimental Analysis of Behavior
JO  - Journal of the Experimental Analysis of Behavior
JA  - J Exp Anal Behav
Y1  - 1958///
VL  - 1
SP  - 31
EP  - 43
CY  - US
PB  - Journal of the Experimental Analysis of Behavior
SN  - 0022-5002
SN  - 1938-3711
N1  - Accession Number: 1959-07701-001. PMID: 13870167 Partial author list: First Author & Affiliation: Blough, Donald S.; National Institute of Mental Health, Bethesda, Md. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19590401. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 13. Issue Publication Date: 1958. 
AB  - The presentation, in detail, of a method for studying psychophysical thresholds in the pigeon. Essentially, through operant conditioning techniques, the pigeon is taught to press one key when a stimulus is perceived and a second key when it is not perceived. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - PSYCHOPHYSICS
KW  - THRESHOLDS
KW  - IN PIGEON
KW  - STUDY METHOD
KW  - PIGEON
KW  - PSYCHOPHYSICAL THRESHOLDS
KW  - LEARNING & MEMORY
KW  - 1958
KW  - No terms assigned
KW  - 1958
DO  - 10.1901/jeab.1958.1-31
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07701-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-12000-007
AN  - 2005-12000-007
AU  - Garmezy, Norman
T1  - The training program of the National Institute of Mental Health: Its implications for mental health programs.
JF  - American Psychologist
JO  - American Psychologist
JA  - Am Psychol
Y1  - 1958/01//
VL  - 13
IS  - 1
SP  - 37
EP  - 40
CY  - US
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
N1  - Accession Number: 2005-12000-007. Partial author list: First Author & Affiliation: Garmezy, Norman; National Institute of Mental Health, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Conference of Chief Psychologists in State Mental Health Programs, Aug, 1956, Chicago, IL. Conference Note: This paper was presented at the aforementioned conference. Major Descriptor: Community Mental Health; Mental Health; Mental Health Programs; Mental Health Services; Psychotherapy Training. Minor Descriptor: Funding. Classification: Professional Education & Training (3410). Population: Human (10). Location: US. Page Count: 4. Issue Publication Date: Jan, 1958. Copyright Statement: American Psychological Association. 1958. 
AB  - The year 1956 marked the tenth anniversary of the Training Grants Program of the National Institute of Mental Health (NIMH). From very meager beginnings in 1948 they had advanced to the very substantial position which they now occupy in fiscal year 1957. This article looks backward briefly to when the National Mental Health Act was passed with the goal of improving the mental health of our nation. It describes the objectives and growth of the NIMH mental health program, which was established to help attain this goal. The article also describes several ongoing public mental health programs that reflect NIMH training grant support and problems in program implementation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Training Grants Program of the National Institute of Mental Health
KW  - training program
KW  - National Mental Health Act
KW  - 1958
KW  - Community Mental Health
KW  - Mental Health
KW  - Mental Health Programs
KW  - Mental Health Services
KW  - Psychotherapy Training
KW  - Funding
KW  - 1958
DO  - 10.1037/h0038374
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12000-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-07282-001
AN  - 1959-07282-001
AU  - Geisser, Seymour
T1  - A note on McQuitty's index of concomitance.
JF  - Educational and Psychological Measurement
JO  - Educational and Psychological Measurement
JA  - Educ Psychol Meas
Y1  - 1958///
VL  - 18
SP  - 125
EP  - 128
CY  - US
PB  - Sage Publications
SN  - 0013-1644
SN  - 1552-3888
N1  - Accession Number: 1959-07282-001. Partial author list: First Author & Affiliation: Geisser, Seymour; National Institute of Mental Health. Release Date: 19590301. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychometrics & Statistics & Methodology (2200). Page Count: 4. Issue Publication Date: 1958. 
AB  - A concomittance coefficient is derived that is considered to have 2 advantages over the one proposed by McQuitty in (a) being sensitive only to the number of agreements, and (b) being capable of being related to known sampling distributions. The coefficient is stated as: C = (r + k - n)/rk, in which r = number of people marking yes to at least one of the ideas, k = number of people marking yes to A, and r = number of people marking yes to B. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MCQUITTY
KW  - INDEX OF CONCOMITANCE
KW  - MODIFICATION PROPOSAL
KW  - CORRELATION
KW  - CONCOMITANCE COEFFICIENT
KW  - STATISTICS
KW  - 1958
KW  - No terms assigned
KW  - 1958
DO  - 10.1177/001316445801800112
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07282-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-07982-001
AN  - 1959-07982-001
AU  - Bayley, Nancy
T1  - Value and limitations of infant testing.
JF  - Children
JO  - Children
JA  - Children
Y1  - 1958///
VL  - 5
SP  - 129
EP  - 133
CY  - US
PB  - United States Children’s Bureau
SN  - 0009-4064
N1  - Accession Number: 1959-07982-001. Other Journal Title: Children Today. Partial author list: First Author & Affiliation: Bayley, Nancy; National Institute of Mental Health. Release Date: 19590401. Correction Date: 20130617. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 5. Issue Publication Date: 1958. 
AB  - After reviewing briefly the history of the psychological testing of infants, the author discusses growth studies of normal infants, the Berkeley growth studies, hereditary determinants of mental development, the effects of environment on intellectual development, and the uses of tests both for persons concerned and persons tested. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - INFANCY
KW  - TESTING OF
KW  - CHILDHOOD & ADOLESCENCE
KW  - 1958
KW  - No terms assigned
KW  - 1958
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07982-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1959-07482-001
AN  - 1959-07482-001
AU  - Blough, Donald S.
T1  - Rise in the pigeon's threshold with a red test stimulus during dark adaptation.
JF  - Journal of the Optical Society of America
JO  - Journal of the Optical Society of America
JA  - J Opt Soc Am
Y1  - 1958///
VL  - 48
SP  - 274
EP  - 274
CY  - US
PB  - Optical Society of America
SN  - 0030-3941
N1  - Accession Number: 1959-07482-001. PMID: 13526049 Other Journal Title: Journal of the Optical Society of America, A, Optics, Image & Science; Journal of the Optical Society of America, A, Optics, Image Science & Vision. Partial author list: First Author & Affiliation: Blough, Donald S.; National Institute of Mental Health, Bethesda, Md. Release Date: 19590401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 1. Issue Publication Date: 1958. 
AB  - Following pre-exposure to white light the pigeon's threshold to a 700 mμ falls slightly at first, then rises 0.1-0.2 log units and falls once more. The rise and fall occur later with increasing duration of pre-exposure. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - PIGEON
KW  - DARK ADAPTATION IN
KW  - DARK ADAPTATION
KW  - WHITE LIGHT PRE-EXPOSURE &
KW  - VISION
KW  - 1958
KW  - No terms assigned
KW  - 1958
DO  - 10.1364/JOSA.48.000274
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07482-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-13096-001
AN  - 2005-13096-001
AU  - Rosvold, H. Enger
AU  - Mishkin, Mortimer
AU  - Szwarcbart, Maria K.
T1  - Effects of subcortical lesions in monkeys on visual-discrimination and single-alternation performance.
JF  - Journal of Comparative and Physiological Psychology
JO  - Journal of Comparative and Physiological Psychology
JA  - J Comp Physiol Psychol
Y1  - 1958/08//
VL  - 51
IS  - 4
SP  - 437
EP  - 444
CY  - US
PB  - American Psychological Association
SN  - 0021-9940
N1  - Accession Number: 2005-13096-001. PMID: 13575600 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Rosvold, H. Enger; National Institute of Mental Health, MD, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Caudate Nucleus; Delayed Alternation; Superior Colliculus; Visual Discrimination. Minor Descriptor: Animal Learning; Monkeys. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 1958. Copyright Statement: American Psychological Association. 1958. 
AB  - Tested whether or not monkeys with lesions in the superior colliculus would show impairment in learning a visual-discrimination task, while animals with lesions in the head of the caudate nucleus would show impairment in learning a delayed-response-type task. Ss were 29 monkeys. Each operated group served as a control for the other group. There was, in addition, an unoperated control group. Visual-discrimination learning was not impaired in any of the operated animals. The learning scores of all the operated animals, including those with extensive lesions in the superior colliculus, fell within the range of scores obtained by the group of unoperated controls. In view of the severe visual impairment reported in cats with collicular lesions, no explanation, other than a recourse to species differences, can be offered to account for the lack of effect following similar damage in monkeys. While it is possible that the damage was not extensive enough to produce impairment, it should be noted that relatively less extensive destruction in the caudate nucleus produced marked alternation deficit. The negative visual-discrimination results leave open the two related questions of how the inferotemporal cortex is related to visual-discrimination functions, and what function is served in monkey by the connections which have been described between the temporal neocortex and the superior colliculus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain lesions
KW  - superior colliculus
KW  - caudate nucleus
KW  - visual discrimination task
KW  - delayed response task
KW  - single-alternation performance
KW  - monkeys
KW  - 1958
KW  - Caudate Nucleus
KW  - Delayed Alternation
KW  - Superior Colliculus
KW  - Visual Discrimination
KW  - Animal Learning
KW  - Monkeys
KW  - 1958
DO  - 10.1037/h0038337
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13096-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rosenberg, Herbert H.
T1  - The Administrative State.
JO  - Administrative Science Quarterly
JF  - Administrative Science Quarterly
Y1  - 1958/09//
VL  - 3
IS  - 2
M3  - Book Review
SP  - 265
EP  - 267
PB  - Administrative Science Quarterly
SN  - 00018392
AB  - The article reviews the book "The Administrative State," by Fritz Morstein Marx.
KW  - BUREAUCRACY
KW  - NONFICTION
KW  - MARX, Fritz Morstein
KW  - ADMINISTRATIVE State, The (Book)
N1  - Accession Number: 6439375; Rosenberg, Herbert H. 1; Affiliations: 1: Chief, Research Resources Section, Office of Research Planning, National Institutes of Health, Bethesda, Maryland.; Issue Info: Sep58, Vol. 3 Issue 2, p265; Thesaurus Term: BUREAUCRACY; Subject Term: NONFICTION; Reviews & Products: ADMINISTRATIVE State, The (Book); People: MARX, Fritz Morstein; Number of Pages: 3p; Document Type: Book Review
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=6439375&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Herbst, William P.
T1  - Management of inoperable cancer of the prostate.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1958/09//
VL  - 13
IS  - 9
M3  - Article
SP  - 574
EP  - 575
SN  - 0016867X
N1  - Accession Number: 17821682; Herbst, William P. 1,2; Source Information: Sep1958, Vol. 13 Issue 9, p574; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 978
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17821682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Perlin, Seymour
T1  - Psychiatric screening in a home for the aged.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1958/11//
VL  - 13
IS  - 11
M3  - Article
SP  - 747
EP  - 751
SN  - 0016867X
N1  - Accession Number: 17810310; Perlin, Seymour 1; Source Information: Nov1958, Vol. 13 Issue 11, p747; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 2403
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17810310&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2006-05960-001
AN  - 2006-05960-001
AU  - Bobbitt, Joseph M.
T1  - Psychology on Display.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1958/11//
VL  - 3
IS  - 11
SP  - 321
EP  - 323
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05960-001. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Health Promotion; Mental Health; Psychologists; Social Sciences. Minor Descriptor: History of Psychology; Social Psychology. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Reviewed Item: Havemann, Ernest. The Age of Psychology=New York: Simon and Schuster, 19S7. Pp. ix + 115. $3.50 (cloth); $1.00 (paper); 1957. Page Count: 3. Issue Publication Date: Nov, 1958. 
AB  - Reviews the book, The Age of Psychology by Ernest Havemann (see record [rid]1959-00015-000[/rid]). The author appears unaware of the fact that the prevention of illness and promotion of mental health are becoming today reachable objectives and that the task involved goes far beyond the clinical domain, encompassing social psychology and the other social sciences in their most sophisticated possibilities. None of the research on rehabilitation of mental patients, problems of the aging population, the mental-health effects of school experience, child development, and other hopeful approaches to the improvement of the mental health of our people is covered in this book. Perhaps the big disappointment, therefore, lies in the failure of the author to show that psychology and its related disciplines are now emerging as areas of study basically related to the everyday problems of everyday people, whether they be clinically ill or not. The book will be unsatisfying to many psychologists. Possibly the average man will learn something from it, but he will not learn much about psychology as a serious scientific discipline. Nor will he gain perspective in the understanding of behavioral science, nor learn much about what is happening in psychology today or during the last five or ten years. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - motivation research
KW  - social psychology
KW  - social sciences
KW  - mental health promotion
KW  - age of psychology
KW  - 1958
KW  - Clinical Psychology
KW  - Health Promotion
KW  - Mental Health
KW  - Psychologists
KW  - Social Sciences
KW  - History of Psychology
KW  - Social Psychology
KW  - 1958
U2  - Havemann, Ernest. (1957); The Age of Psychology; New York: Simon and Schuster, 19S7. Pp. ix + 115. $3.50 (cloth); $1.00 (paper)
DO  - 10.1037/005712
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05960-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - 
AU  - Birren, James E.1
T1  - Aging and Psychological Adjustment.
JO  - Review of Educational Research
JF  - Review of Educational Research
J1  - Review of Educational Research
PY  - 1958/12//
Y1  - 1958/12//
VL  - 28
IS  - 5
CP  - 5
M3  - Article
SP  - 475
EP  - 490
SN  - 00346543
AB  - This articles reviews the research on the increase of scientific and professional interest in older persons which involves aging and psychological adjustment. Adult adjustment, despite the difference in content, might involve the same psychological mechanisms as in childhood. Developmental model for aging which includes the variables pertinent to adjustment was described by the author. Consequences of early childhood experiences and educational practices will increasingly be examined for their significance not only to the early years but also to the adjustment of the mature and aging adult.
KW  - Adjustment (Psychology) in old age
KW  - Geropsychology
KW  - Developmental biology
KW  - Adjustment (Psychology)
KW  - Adaptability (Psychology)
KW  - Aging
KW  - Growth
KW  - Human growth
N1  - Accession Number: 18811047; Authors: Birren, James E. 1; Affiliations:  1: Section on Aging, National Institute of Mental Health, U. S. Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland; Subject: Adjustment (Psychology) in old age; Subject: Geropsychology; Subject: Developmental biology; Subject: Adjustment (Psychology); Subject: Adaptability (Psychology); Subject: Aging; Subject: Growth; Subject: Human growth; Number of Pages: 16p; Record Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=18811047&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
AU  - Hunt, G. Halsey
T1  - Implications of aging as predicted by population changes.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1959/01//
VL  - 14
IS  - 1
M3  - Article
SP  - 1
EP  - 7
SN  - 0016867X
N1  - Accession Number: 20877890; Hunt, G. Halsey 1,2; Source Information: Jan1959, Vol. 14 Issue 1, p1; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 3943
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20877890&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - CHAP
ID  - 2007-00124-002
AN  - 2007-00124-002
AU  - Bobbitt, Joseph M.
ED  - Roe, Ann
ED  - Gustad, John W.
ED  - Moore, Bruce V.
ED  - Ross, Sherman
ED  - Skodak, Marie
ED  - Roe, Ann, (Ed)
ED  - Gustad, John W., (Ed)
ED  - Moore, Bruce V., (Ed)
ED  - Ross, Sherman, (Ed)
ED  - Skodak, Marie, (Ed)
T1  - Opening Remarks.
T2  - Graduate education in psychology: Report of the Conference on Graduate Education in Psychology.
Y1  - 1959///
SP  - 19
EP  - 23
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2007-00124-002. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20070205. Correction Date: 20151221. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Language: English. Conference Information: Conference on Graduate Education in Psychology, Nov-Dec, 1958, Miami Beach, FL, US. Conference Note: Reported at the aforementioned conference sponsored by the Education and Training Board of the American Psychological Association. Major Descriptor: Graduate Psychology Education. Minor Descriptor: Sciences. Classification: Professional Education & Training (3410). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - This chapter presents the opening remarks given at the 1958 Conference on Graduate Education in Psychology. It states that the pressing reason for this conference is the need to resolve the difficulties growing out of the dual development as both a science and a profession. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - graduate psychology education
KW  - science
KW  - profession
KW  - 1959
KW  - Graduate Psychology Education
KW  - Sciences
KW  - 1959
DO  - 10.1037/11398-002
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00124-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-004
AN  - 2006-20945-004
AU  - Evarts, Edward V.
AU  - Butler, Robert N.
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - A Review of the Effects of Chlorpromazine and Reserpine in Patients with Mental Disorders.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 64
EP  - 82
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-004. Partial author list: First Author & Affiliation: Evarts, Edward V.; Section on Physiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Chlorpromazine; Drug Therapy; Drugs; Mental Disorders; Psychopharmacology. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 19. 
AB  - The purpose of this review is to clarify the status of chlorpromazine and reserpine as pharmacotherapeutic agents in mental illness. In order to evaluate the therapeutic efficacy of a given pharmacological agent, one must answer certain questions about the action of the agent. Three of these questions are: What are the effects of the drug? Are the effects beneficial? How do the effects compare with those of other therapies? In this review, an outline suggested by these three questions will be followed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - pharmacotherapeutic agents
KW  - chlorpromazine
KW  - reserpine
KW  - mental disorders
KW  - drug effects
KW  - 1959
KW  - Chlorpromazine
KW  - Drug Therapy
KW  - Drugs
KW  - Mental Disorders
KW  - Psychopharmacology
KW  - 1959
DO  - 10.1037/11259-004
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-006
AN  - 2006-20945-006
AU  - Cole, Jonathan O.
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - The Evaluation of the Effectiveness of Treatment in Psychiatry.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 92
EP  - 107
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-006. Partial author list: First Author & Affiliation: Cole, Jonathan O.; Psychopharmacology Service Center, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Evaluation; Psychiatric Patients; Psychiatry; Treatment Effectiveness Evaluation. Minor Descriptor: Experiment Controls; Followup Studies. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Inpatient (50). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 16. 
AB  - In considering the various steps involved in the organization of research to evaluate the effects of a psychiatric treatment, it seemed best to break the process down into (a) the control problem, (b) the evaluation of the patient, and (c) the follow-up problem. No attempt will be made to consider in detail the specific evaluation of the effects of any particular treatment; only relatively nonspecific aspects of the treatment situation will be discussed. Since a good deal of the work evaluating the ataraxic drugs has been done upon hospitalized psychiatric patients, most of the discussion will be focused toward that group. The problems involved in evaluating the effects of therapy on outpatients would seem to be similar, only more complex. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment effectiveness evaluation
KW  - psychiatry
KW  - control problem
KW  - patient evaluation
KW  - follow-up problem
KW  - 1959
KW  - Evaluation
KW  - Psychiatric Patients
KW  - Psychiatry
KW  - Treatment Effectiveness Evaluation
KW  - Experiment Controls
KW  - Followup Studies
KW  - 1959
DO  - 10.1037/11259-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-007
AN  - 2006-20945-007
AU  - Kramer, Morton
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - Public Health and Social Problems in the Use of Tranquilizing Drugs.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 108
EP  - 142
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-007. Partial author list: First Author & Affiliation: Kramer, Morton; Biometrics Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Drug Therapy; Social Issues; Tranquilizing Drugs. Minor Descriptor: Public Health. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 35. 
AB  - This reprinted chapter originally appeared in (Public Health Monograph, 1956, No. 41). (The following abstract of the original article appeared in record [rid]1957-08051-001[/rid].) The advent of tranquilizing drugs is considered in relation to possible consequences for the psychiatric profession, other branches of medical practice, the epidemiologist, the social scientist, and the bio-statistician. Gaps in present knowledge concerning the extent to which tranquilizing drugs are in use, their immediate and long range effects, and their possible effects on mental hospital populations are pointed out. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - tranquilizing drugs
KW  - public health
KW  - social problems
KW  - 1959
KW  - Drug Therapy
KW  - Social Issues
KW  - Tranquilizing Drugs
KW  - Public Health
KW  - 1959
DO  - 10.1037/11259-007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-015
AN  - 2006-20945-015
AU  - Rosvold, H. Enger
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - Evaluation of the Effects of Pharmacological Agents on Social Behavior.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 245
EP  - 254
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-015. Partial author list: First Author & Affiliation: Rosvold, H. Enger; Section on Animal Behavior, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Drugs; Evaluation; Mental Disorders; Pharmacology; Social Behavior. Minor Descriptor: Animal Social Behavior; Drug Therapy; Screening; Treatment Effectiveness Evaluation. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 10. 
AB  - Mental illness is manifest for the most part in the inappropriate manner in which the individual interacts with other people. He may be too aggressive, too hostile, too fearful, too unresponsive, too amorous for his fellows to bear; or perhaps he may perceive his role in the group to be something other than the rest of his group is willing to concede. Unhappy over his unsatisfactory interpersonal relationships, he comes to treatment; or troublesome to society, he is required to be treated. Whichever the reason, it is hoped that the treatment will result in the individual's being more at ease with his fellows and behaving more like them. It is thus pertinent to evaluate the effectiveness of pharmacotherapy in changing an individual's social behavior. Either human or other animal groups may be used. In the discussion that follows the term social behavior will refer to any behavior that an animal displays in relation to one or more other individuals that does not appear or cannot be observed when an animal is alone. It is an animal's responses to the demands made of him by other individuals, and those responses are frequently, though not always, different from his behavior when alone. It is the purpose of this paper to describe some techniques for studying such behavior and to suggest how they might be used in evaluating the effects of pharmacological agents. These methods may be applied to four different aspects of an evaluation program. These may be characterized as (a) description, (b) screening, (c) localization, and (d) extension. A discussion on this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social behavior
KW  - mental illness
KW  - evaluation
KW  - pharmacological agents
KW  - 1959
KW  - Drugs
KW  - Evaluation
KW  - Mental Disorders
KW  - Pharmacology
KW  - Social Behavior
KW  - Animal Social Behavior
KW  - Drug Therapy
KW  - Screening
KW  - Treatment Effectiveness Evaluation
KW  - 1959
DO  - 10.1037/11259-015
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-018
AN  - 2006-20945-018
AU  - Evarts, Edward V.
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - A Discussion of the Relevance of Effects of Drugs on Animal Behavior to the Possible Effects of Drugs on Psychopathological Processes in Man.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 284
EP  - 306
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-018. Partial author list: First Author & Affiliation: Evarts, Edward V.; Section on Physiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Animal Ethology; Drugs; Psychopathology; Psychopharmacology. Minor Descriptor: Animals; Drug Therapy; Mental Disorders; Schizophrenia; Screening Tests. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 23. 
AB  - Since the introduction of chlorpromazine, reserpine, and numerous other 'tranquilizing agents,' there has been a great increase in the quantity of research devoted to the discovery of additional, and perhaps superior, 'psychotherapeutic' drugs. It is to be hoped that expansion of research in this area will be productive of more than new and better tranquilizing agents. The limitations of therapeutic agents with psychological effects similar to those of chlorpromazine and reserpine have become increasingly clear: on the basis of evidence available to date, such drugs would appear to make disturbed patients cooperative but to leave them none the less psychotic. The widespread use of reserpine and chlorpromazine in mental hospitals has certainly resulted in a beneficial change in the atmosphere of formerly disturbed psychiatric wards; the fact remains that, in spite of these beneficial changes, patients have in large measure remained hospitalized. In short, the tranquilizing drugs appear to have transformed disturbed psychotic patients into undisturbed psychotic patients. It is the purpose of this paper to examine certain of the problems which may arise in connection with attempts to develop drugs whose therapeutic effects may exceed mere 'tranquilization'; that is, drugs which may actually alter certain of the primary psychopathological disturbances of the psychotic patient. As will be made clear later on, these primary psychopathological disorders are not seen as including motor hyperactivity, assaultiveness, etc., which are viewed as secondary symptoms of certain more basic psychological deficits. There are many approaches which might be employed in attempts to discover drugs which do more than tranquilize. In the present paper, a relatively restricted segment of this potentially vast area will be dealt with. In particular, this paper will discuss the degree to which the effects of drugs on animal behavior may be used in the selection of agents which may alter specific aspects of the primary psychopathological disorders of schizophrenia. The use of animal screening tests in the selection of drugs has been singled out for discussion because, in the opinion of this author, it represents the most difficult, and possibly the limiting step in the process by which new drugs are brought to therapeutic trial. The discussion will deal with the selection of drugs for therapeutic trial in schizophrenic disorders, rather than in mental disorders in general. The clinical field has been restricted in order to allow an attempt to relate the results of screening tests to possible effects of drugs on specific forms of psychological disorder; such an effort would be considerably more difficult if the range of clinical disorders under discussion were of unlimited scope. A discussion about this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychopathological processes
KW  - schizophrenic disorders
KW  - drug effects
KW  - animal behavior
KW  - animal screening tests
KW  - 1959
KW  - Animal Ethology
KW  - Drugs
KW  - Psychopathology
KW  - Psychopharmacology
KW  - Animals
KW  - Drug Therapy
KW  - Mental Disorders
KW  - Schizophrenia
KW  - Screening Tests
KW  - 1959
DO  - 10.1037/11259-018
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-023
AN  - 2006-20945-023
AU  - Kramer, Morton
AU  - Greenhouse, Samuel W.
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - Determination of Sample Size and Selection of Cases.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 356
EP  - 371
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-023. Partial author list: First Author & Affiliation: Kramer, Morton; Biometrics Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Sample Size; Sampling (Experimental); Tranquilizing Drugs. Classification: Research Methods & Experimental Design (2260); Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16. 
AB  - This paper will consider some of the problems involved in determining the size of both experimental and control groups (i.e., the number of cases needed) in experiments designed to detect effects of tranquilizing drugs. An essential part of the planning stage of an experiment is to determine the size of the control and experimental groups to be studied. The size of these groups can be established adequately only by taking account of the following considerations: (a) an explicit statement of the question(s) to be investigated; (b) the minimum difference the investigator desires to detect as significant; and (c) the certainty with which the investigator desires to avoid each of two possible errors that can be made in accepting or rejecting the hypotheses tested. Although the questions that this conference wants to answer about the effect of the transquilizers have as yet not been specified, let us assume that the problem under investigation is to determine the effect of a tranquilizer on the improvement rate in male schizophrenic patients hospitalized in state mental hospitals. We will assume further that we are in that Utopian stage where diagnostic methods and methods of determining improvement are sufficiently well standardized from hospital to hospital within the same state system as well as between state systems so that results may be compared within or between hospitals without introducing uncontrolled variations into the experiment from these two sources (i.e., diagnosis and measurement of improvement). A discussion on this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - sample size
KW  - case selection
KW  - tranquilizing drugs
KW  - drug effects
KW  - 1959
KW  - Sample Size
KW  - Sampling (Experimental)
KW  - Tranquilizing Drugs
KW  - 1959
DO  - 10.1037/11259-023
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2006-20945-028
AN  - 2006-20945-028
AU  - Rosenthal, David
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
ED  - Cole, Jonathan O., (Ed)
ED  - Gerard, Ralph W., (Ed)
T1  - Drug Research Design in Psychiatric Outpatient Setting.
T2  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
SP  - 434
EP  - 446
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-028. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Experimental Design; Outpatients; Psychiatric Patients; Psychopharmacology; Research Setting. Classification: Research Methods & Experimental Design (2260); Clinical Psychopharmacology (3340). Population: Human (10); Outpatient (60). Intended Audience: Psychology: Professional & Research (PS). Page Count: 13. 
AB  - I shall discuss what I know best from actual experience, namely the 'own-control' type of design. I shall describe some major steps in own-control procedures and discuss some problems encountered at each step. Some points will be germane to all kinds of drug research with psychiatric patients, but in the main I shall concentrate on special problems posed by the outpatient setting. A drug is most likely to be tested at either of two early stages in its clinical history: 1. An exploratory stage: the drug may have been found to have some special effects with experimental animals or nonpsychiatric clinical groups, and we wish to see how it affects various types of psychiatric patients. 2. A testing stage: the drug has been explored clinically and has been reported to be effective for certain diagnostic groups. If we are at the exploratory stage, the patient sample will be of heterogeneous composition. At the second stage we will be more likely to test the drug for one diagnostic group at a time. I shall concern myself with the exploratory stage because drugs are almost always pretested on inpatients where routine procedures are more closely observed and controlled, and because the applicability to psychiatric outpatients of preliminary reports resulting from such early studies is often doubtful. Moreover, such a wide variety of clinical groups are found in outpatient clinics that most are not yet represented in preliminary studies. They include immaturity problems, diverse neuroses, ambulatory schizophrenics, personality disorders, etc. (as well as mental defectives, organic syndromes, antisocial psychopaths, and some quite disorganized schizophrenics whom we shall not consider). Our task is to see whether any of these kinds of outpatients may be helped by a drug, and the sample is denned only in terms of the kinds of patients excluded. That has an important bearing on the type of research design employed, because it renders inadequate the usual procedure which aims at measuring drug-induced changes in the sample group as a whole. A discussion on this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric patients
KW  - outpatient setting
KW  - drug research design
KW  - 1959
KW  - Experimental Design
KW  - Outpatients
KW  - Psychiatric Patients
KW  - Psychopharmacology
KW  - Research Setting
KW  - 1959
DO  - 10.1037/11259-028
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-028&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39118-001
AN  - 2013-39118-001
AU  - Redl, Fritz
T1  - The life space interview workshop, 1957: Eveoleen N. Rexford, M.D., chairman: 1. Strategy and techniques of the life space interview.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/01//
VL  - 29
IS  - 1
SP  - 1
EP  - 18
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39118-001. PMID: 13627104 Partial author list: First Author & Affiliation: Redl, Fritz; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1958. Conference Note: Which was presented at the presented at the aforementioned conference. Major Descriptor: Emotional States; Orthopsychiatry; Psychotherapeutic Transference; Scientific Communication. Minor Descriptor: Interviews. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Page Count: 18. Issue Publication Date: Jan, 1959. 
AB  - This article provides an overview of the 1957 Life Space Interview Workshop of the American Orthopsychiatric Association. The Workshop focused on the strategy and techniques of the life space interview. The peculiar ritual and the behavioral prescriptions to which the patient is bound, as well as the variety of technical tools with which the therapist arms himself, make sense only when viewed as steps to the following goals: To isolate the patient enough from the pressures of adjustment he finds ; in his daily life, so as to create purposely an atmosphere which resembles, more nearly the conditions under which the roots for his neurosis developed, to get the patient to re-establish around the person of the therapist the emotional relationships toward focal people in his life which were experienced by him at that time and Through skillful manipulation of these emotional relationships-especially those of transference-and through skillful reaction to the patient's fantasy productions and behaviors, to bring about the following phenomena: (a) to enable the patient to bring unconscious material into open manifestation- and that applies not only to the id but also to unconscious ego and superego elements; (b) to help the ego recognize and handle previous experiences as well as reorganize its own techniques so that pathological symptom formation or character distortion is not any longer necessary; and (c) to give some aid to the ego in reorienting the healthier personality thus emerging, to the actual present-day tasks of life adjustment, so that dependence on therapy can safely cease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Life Space Interview Workshop
KW  - American Orthopsychiatric Association
KW  - scientific communication
KW  - emotional relationships
KW  - transference
KW  - 1959
KW  - Emotional States
KW  - Orthopsychiatry
KW  - Psychotherapeutic Transference
KW  - Scientific Communication
KW  - Interviews
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00163.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39118-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39118-002
AN  - 2013-39118-002
AU  - Dittmann, Allen T.
AU  - Kitchener, Howard L.
T1  - The life space interview workshop, 1957: 2. Life space interviewing and individual play therapy: A comparison of techniques.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/01//
VL  - 29
IS  - 1
SP  - 19
EP  - 26
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39118-002. PMID: 13627105 Partial author list: First Author & Affiliation: Dittmann, Allen T.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Individual Psychotherapy; Orthopsychiatry; Play Therapy; Scientific Communication. Minor Descriptor: Interviews. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Page Count: 8. Issue Publication Date: Jan, 1959. 
AB  - This article presents an overview of the 1957 Life Space Interview Workshop conducted by the American Orthopsychiatric Association. The focus of the Workshop was on the comparison of techniques of life space interviewing and individual play therapy. In psychotherapy the goal for any interview is to provide an opportunity for the exploration of early conflicts of which the present symptoms are derivatives. In life space interviews the goals are action goals in keeping with the issue which initiated the interview. Where the child refuses to participate or has been removed from activity the goal is always action; although it may not be possible to get him back into the activity today, still the goal is to settle whatever is holding him back and return him to the activity as soon as possible. Where the interview is initiated by the child, the goal is to get the question answered as soon as possible or to refer the child to someone from whom he can get an answer. In addition to specific goals, there are of course in every life space interview the over-all treatment goals of the residential program as a whole. The next main basis for comparison is the role structure of the interview. The psychotherapist's role is relatively unmoved by the day-today activities of the ward, and while therapists don't go out of their way to avoid meeting the children in the halls, there isn't much contact outside the interviews. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Life Space Interview Workshop
KW  - American Orthopsychiatric Association
KW  - individual play therapy
KW  - psychotherapy
KW  - scientific communication
KW  - 1959
KW  - Individual Psychotherapy
KW  - Orthopsychiatry
KW  - Play Therapy
KW  - Scientific Communication
KW  - Interviews
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00164.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39118-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39118-004
AN  - 2013-39118-004
AU  - Shakow, David
T1  - Research in child development: A case illustration of the psychologist's dilemma.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/01//
VL  - 29
IS  - 1
SP  - 45
EP  - 59
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39118-004. PMID: 13627107 Partial author list: First Author & Affiliation: Shakow, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Professional Ethics; Professional Standards; Psychologists. Minor Descriptor: Childhood Development; Observers. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 15. Issue Publication Date: Jan, 1959. 
AB  - This article presents a case illustration of the psychologist's dilemma. The dilemma stated simply is: How can one study human psychological phenomena scientifically with a minimum of distortion and ethicall-with a minimum of inevitable trespass? In fact psychoanalysts are perhaps faced with this dilemma above all others in the psychological field. The problem is so full of affect that there is danger of becoming too aware of the dilemma to the point of being anxiety-ridden by it, which must of course equally be guarded against. Part of the dilemma is how one can study human psychological phenomena scientifically with a minimum of distortion. It will be recognized that the 'distortion' that results is in a way an instance of what James called 'the psychologist's fallacy'-the error of method and interpretation in which the psychologist confuses his own knowledge about the process with what the subject directly experiences in the process. This fallacy is a peculiar hazard of the psychologist-observer when compared with the observer in the physical and biological sciences, although the hazard exists as well in nonhuman psychological fields where one is dealing with descriptions of animal behavior. The author argued for the importance of child development research to be undertaken by a guidance center-most desirably an institution with the status and standards of the Judge Baker Guidance Center. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child development
KW  - psychologists
KW  - ethical dilemma
KW  - observers
KW  - professional standards
KW  - 1959
KW  - Professional Ethics
KW  - Professional Standards
KW  - Psychologists
KW  - Childhood Development
KW  - Observers
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00166.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39118-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CONF
ID  - 2006-20945-000
AN  - 2006-20945-000
AU  - Cole, Jonathan O.
AU  - Gerard, Ralph W.
ED  - Cole, Jonathan O.
ED  - Gerard, Ralph W.
T1  - Psychopharmacology: Problems in evaluation.
Y1  - 1959///
CY  - Washington, DC, US
PB  - National Academy of Sciences
N1  - Accession Number: 2006-20945-000. Partial author list: First Author & Affiliation: Cole, Jonathan O.; Psychopharmacology Service Center, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Classic Book; Conference Proceedings. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Illness, Sep, 1956, Washington, DC, US. Conference Note: Proceedings of a sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Evaluation; Psychopharmacology. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 662. 
AB  - The organization of this volume has followed the various stages through which the preparation for the Conference on The Evaluation of Pharmacotherapy in Mental Illness and the actual conference went. A seventh paper, by Dr. Jack R. Ewalt, was presented at the dinner given on Friday, 21 September 1956. The general character resembles that of the introductory papers and it was therefore included with them. The first section of this volume, therefore, consists of the seven working papers, two of which were brought up to date just before the conference in September 1956, together with Dr. Gerard's summary. At the January planning meeting it was decided that five committees should be formed, composed for the most part of those participating in the planning meeting. These committees were to include the Committee on Preliminary Screening of Drugs, under the chairmanship of Dr. Louis Goodman, which was to review thoroughly our knowledge of the basic mechanisms of action of these psychoactive compounds, and more particularly the adequacy of available methods for the selection and the animal and early human screening of compounds of this general sort. The next three committees were organized as a group in order that the field of clinical drug evaluation, which was to be the primary emphasis of the conference, should receive the most thorough possible scrutiny. The general clinical area was divided into three sections. The first section, that dealing with the problems attached to the selection of patient groups for study and the problem of adequate scientific controls in clinical researches, was assigned to the Committee on Patient Selection and Controls under the chairmanship of Dr. John Clausen. The second clinical area encompassed the influence of the environment in which the drug studies were done and the problems attached to drug administration itself. This area was gradually expanded to include the more general aspects of test design in clinical drug evaluation and was assigned to the Committee on Test Conditions, under the chairmanship of Dr. Alfred Bay. The third clinical area was that of evaluation, and the third committee, the Committee on Evaluation, was to concern itself intensively with the problems of evaluation and the more detailed consideration of some of the available techniques for the measurement of change in psychiatric patients. Dr. Milton Greenblatt chaired the Committee on Evaluation and also served as 'superchairman' and coordinator of the three clinical committees. The fifth committee was called the Committee on Planning and Coordination and was to serve both as an executive committee for the conference and to consider, in broader terms, the implications of the conference. Its major attention was to be devoted to the preparation of plans for the implementation of policy recommendations and research ideas which would emerge from the conference itself. The organization of the sections devoted to the work of the several committees is not uniform, but has varied with the nature of the committee's activities. The edited discussions have been inserted, wherever they are most appropriate, either following the article to which they are pertinent or in a separate section devoted to the general work of the committee. The summaries prepared by the various committees and presented to the main conference, together with the discussion from the floor following the presentation of these summaries, have been included as a separate section at the end of the volume, and are followed by Dr. Kety's final, over-all analysis of the work of the conference and the consolidated recommendations of the various working groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychopharmacology
KW  - evaluation
KW  - 1959
KW  - Evaluation
KW  - Psychopharmacology
KW  - 1959
U1  - Sponsor: Department of Health, Education, and Welfare, United States Public Health Service, National Institutes of Health; National Institute of Mental Health, US. Grant: 3M-9104. Recipients: No recipient indicated
DO  - 10.1037/11259-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rosvold, H.Enger
T1  - PHYSIOLOGICAL PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1959/02//
VL  - 10
IS  - 1
M3  - Article
SP  - 415
EP  - 454
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Presents information on studies related to the manipulation of brain. Organisation of the brain to serve behavior. Deterioration of the problem solving ability of adult animals; Achievements in the field of conditioned cerebral electrical responses; Reassessment of classical studies delineating neural components of conditioning.
KW  - PROBLEM solving
KW  - RESEARCH
KW  - BRAIN
KW  - HUMAN behavior
KW  - ANIMALS
N1  - Accession Number: 11290181; Rosvold, H.Enger 1; Affiliations: 1: Laboratory of  Psychology,  National Institute of Mental Health Bethesda, Maryland.; Issue Info: 1959, Vol. 10 Issue 1, p415; Thesaurus Term: PROBLEM solving; Thesaurus Term: RESEARCH; Subject Term: BRAIN; Subject Term: HUMAN behavior; Subject Term: ANIMALS; Number of Pages: 40p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - GEN
AU  - Jungk, Robert
AU  - Wilson, Robert R.
AU  - Fine, Jacob
AU  - Rosenthal, Sanford M.
T1  - LETTERS.
JO  - Scientific American
JF  - Scientific American
Y1  - 1959/03//
VL  - 200
IS  - 3
M3  - Letter
SP  - 11
EP  - 16
SN  - 00368733
AB  - Two letters to the editor is presented in response to previous articles including a review by Robert R. Wilson on the book "Brighter Than a Thousand Suns" and "Wound Shock," by Sanford Rosenthal in the December 1958 issue.
KW  - Letters to the editor
KW  - Wilson, Robert R.
KW  - Rosenthal, Sanford
KW  - Brighter Than a Thousand Suns: A Personal History of the Atomic Scientists (Book)
N1  - Accession Number: 19788929; Jungk, Robert; Wilson, Robert R. 1; Fine, Jacob 2; Rosenthal, Sanford M. 3; Affiliations: 1: Cornell University, Ithaca, N.Y.; 2: Harvard Medical School, Boston, Mass.; 3: National Institutes of Health, Bethesda, Md.; Issue Info: Mar1959, Vol. 200 Issue 3, p11; Subject Term: Letters to the editor; Reviews & Products: Brighter Than a Thousand Suns: A Personal History of the Atomic Scientists (Book); People: Wilson, Robert R.; People: Rosenthal, Sanford; Number of Pages: 4p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2013-39119-002
AN  - 2013-39119-002
AU  - Goodrich, D. Wells
T1  - Observational research with emotionally disturbed children: Session I: 2. The choice of situation for observational studies of children.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/04//
VL  - 29
IS  - 2
SP  - 227
EP  - 234
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39119-002. PMID: 13661298 Partial author list: First Author & Affiliation: Goodrich, D. Wells; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Design; Observation Methods; Popular Culture; Regional Differences. Minor Descriptor: Choice Behavior; Emotional Disturbances. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 8. Issue Publication Date: Apr, 1959. 
AB  - In this article author highlights the choice of situation for observational studies of children. In planning any observational study of children's behavior, one question which arises inevitably is where to study the children. A wide spectrum of clinical and scientific issues may become relevant to deciding the location for research observations. The problem of 'choosing a situation' can be considered in reference to the general life context of a child and in reference to the in any specific geographical locations and group situations within any life context. any observational study of children's behavior, one question which arises inevitably is where to study the children. The attempt to differentiate between situational determinants of behavior and those which stem from idiosyncratic aspects of personality has been urged by means of controlled sampling of the subjects and of situations. The laboratory is particularly adapted to studying stress or to testing a few specific hypotheses about personality functioning. The residential institution provides an opportunity to observe the total range of the child's ego functioning. It is a particularly useful place in which to study children's ego strengths and the interaction between social settings and personality. The psychotherapy situation is a useful place to observe the uncovering of specific pathological fantasies and defensive operations and to observe basic change processes occurring in the ego. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - observational studies
KW  - choice of situation
KW  - child behavior
KW  - situational determinants
KW  - geographical locations
KW  - research settings
KW  - 1959
KW  - Experimental Design
KW  - Observation Methods
KW  - Popular Culture
KW  - Regional Differences
KW  - Choice Behavior
KW  - Emotional Disturbances
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00186.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39119-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39119-003
AN  - 2013-39119-003
AU  - Raush, Harold L.
T1  - Observational research with emotionally disturbed children: Session I: 3. On the locus of behavior–observations in multiple settings within residential treatment.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/04//
VL  - 29
IS  - 2
SP  - 235
EP  - 242
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39119-003. PMID: 13661299 Partial author list: First Author & Affiliation: Raush, Harold L.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Observation Methods; Residential Care Institutions; Treatment. Minor Descriptor: Emotional Disturbances; Socialization. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 8. Issue Publication Date: Apr, 1959. 
AB  - In this paper author highlights for the most part about some situational components which enter into behavior. He further highlights about the neglect of situational aspects in personality research. For the chief proposition of the paper is that they meet behavior at the juncture of these two classes of variables, and it is the study of this juncture that he wish mainly to emphasize. There have been many comments on the role of food and its use in the socialization of disturbed children. The relevance of the eating situation was confirmed when they found that such situations-breakfast other mealtimes, the snack period before going to bed-produced considerably fewer hostile interactions than did nonfood settings-structured games, unstructured group activities, and arts and crafts sessions. The influence of situational factors is not limited to their general over-all effects. he has implied that the setting components operated somewhat differently in the two time periods. Both the situational factors and the individual personality components that go into creating behavior have been defined quite loosely in this article. In another sense, the therapeutic situation is a very special one. Particularly in psychoanalysis, but perhaps also to some extent in all therapies where the aims are exploratory rather than repressive, there are built-in mechanics which act as inductive forces toward regression. The precision with which these problems have to be faced depends, of course, on the nature of the questions one is trying to answer, but the issue is always , a ghost in the background, whether or not one attests to its presence in the design of a study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - observational research
KW  - emotionally disturbed children
KW  - multiple settings
KW  - residential treatment
KW  - socialization
KW  - 1959
KW  - Observation Methods
KW  - Residential Care Institutions
KW  - Treatment
KW  - Emotional Disturbances
KW  - Socialization
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00187.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39119-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Boomer, Donald S.
T1  - SUBJECTIVE CERTAINTY AND RESISTANCE TO CHANGE.
JO  - Journal of Abnormal & Social Psychology
JF  - Journal of Abnormal & Social Psychology
Y1  - 1959/05//
VL  - 58
IS  - 3
M3  - Article
SP  - 323
EP  - 328
SN  - 0096851X
AB  - The article discusses a study which examined the relationship between subjects' expressed level of certainty during an experiment and their observable behavior. The study is concerned with the subjects' psychological bases for resisting or conforming to group influence. The study aims to tap subjects' private experience during the application of group pressure in order to learn more about the psychological processes involved. Subjects were undergraduate college students, drawn from a large lower division course in personal and social adjustment.
KW  - PSYCHOLOGY -- Research
KW  - RESISTANCE to change
KW  - PEER pressure in adolescence
KW  - SOCIAL influence
KW  - SOCIAL psychology
KW  - COLLEGE students
KW  - SOCIAL adjustment
N1  - Accession Number: 24425270; Boomer, Donald S. 1; Affiliations: 1 : National Institute of Mental Health;  Source Info: May1959, Vol. 58 Issue 3, p323; Subject Term: PSYCHOLOGY -- Research; Subject Term: RESISTANCE to change; Subject Term: PEER pressure in adolescence; Subject Term: SOCIAL influence; Subject Term: SOCIAL psychology; Subject Term: COLLEGE students; Subject Term: SOCIAL adjustment; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - 24h
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - SOCIAL CLASS AND THE EXERCISE OF PARENTAL AUTHORITY.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1959/06//
VL  - 24
IS  - 3
M3  - Article
SP  - 352
EP  - 366
SN  - 00031224
AB  - <em>The conditions under which middle- and working-class parents punish their pre-adolescent children physically, or refrain from doing so, appear to be quite different. Working-class parents are more likely to respond in terms of the immediate consequences of the child's actions, middle-class parents in terms of their interpretation of the child's intent in acting as he does. This reflects differences in parents' values: Working-class parents value for their children qualities that assure respectability; desirable behavior consists essentially of not violating proscriptions. Middle-class parents value the child's development of internalized standards of conduct; desirable behavior consists essentially of acting according to the dictates of one's own principles. The first necessarily focuses on the act itself, the second on the actor's intent</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL classes
KW  - CHILD psychology
KW  - BEHAVIOR
KW  - CONDUCT of life
KW  - GUARDIAN & ward
KW  - PARENT & child (Law)
N1  - Accession Number: 12581403; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun59, Vol. 24 Issue 3, p352; Subject Term: SOCIAL classes; Subject Term: CHILD psychology; Subject Term: BEHAVIOR; Subject Term: CONDUCT of life; Subject Term: GUARDIAN & ward; Subject Term: PARENT & child (Law); Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Hunt, G. Halsey
AU  - Akers, Robert P.
AU  - Mohler, Stanley R.
T1  - Research grant program of the National Institutes of Health: With special emphasis on research in aging.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1959/06//
VL  - 14
IS  - 6
M3  - Article
SP  - 396
EP  - 403
SN  - 0016867X
N1  - Accession Number: 20877918; Hunt, G. Halsey 1,2; Akers, Robert P. 1,3; Mohler, Stanley R. 1,3; Source Information: Jun1959, Vol. 14 Issue 6, p396; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3556
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Pearlin, Leonard I.
T1  - Social and Personal Stress and Escape Television Viewing.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1959///Summer59
VL  - 23
IS  - 2
M3  - Article
SP  - 255
EP  - 259
SN  - 0033362X
AB  - This article focuses on television viewing and its role in relieving social and personal stress. People's reactions to the strains and stresses induced by their environments take many forms. Watching television, or at least watching certain types of television programs, appears to be the latest mode of response to stress. In modern society, the strains and dislocations that exist between the parts of the system make it unlikely that sizable segments of the population can remain untouched by stress and its consequences. It can be said without exaggeration that stress is a common feature of modern social life. An inquiry was directed specifically to the relationship between indicated escape needs of viewers and their viewing of television for escape purposes. Although most viewers occasionally turn to television for escape, it was expected that those who experienced relatively lasting and intense states of stress would be more typical. The article also presents an argument on the mass media and to the extent that they serve as a means of temporary diversion from tensions, militate against or defer actions that might be directed toward the source of difficulties.
KW  - Stress (Psychology)
KW  - Television viewers
KW  - Television programs
KW  - Mass media
KW  - Psychology
KW  - Vigilance (Psychology)
N1  - Accession Number: 11947797; Pearlin, Leonard I. 1; Affiliations: 1: Sociologist staff of Laboratory Socio-environmental Studies, National Institute of Mental Health.; Issue Info: Summer59, Vol. 23 Issue 2, p255; Thesaurus Term: Stress (Psychology); Thesaurus Term: Television viewers; Thesaurus Term: Television programs; Thesaurus Term: Mass media; Thesaurus Term: Psychology; Subject Term: Vigilance (Psychology); NAICS/Industry Codes: 512110 Motion Picture and Video Production; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 2006-05978-009
AN  - 2006-05978-009
AU  - Carlson, V. R.
T1  - LSD--A Pot of Gold?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1959/06//
VL  - 4
IS  - 6
SP  - 174
EP  - 175
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05978-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Carlson, V. R.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drugs; Lysergic Acid Diethylamide; Pharmacology. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Garattini, S. (Ed); Ghetti, V. (Ed). Psychotcopic Drugs=(Proceedings of the International Symposium on Psychotropic Drugs, Milan, 9-11 May 1957.) Amsterdam: Elsevier Publishing Co., 1957 (distributed by D. Van Nostrand, Princeton, N. J.). Pp. xiv + 606. $19.50; 1957. Page Count: 2. Issue Publication Date: Jun, 1959. 
AB  - Reviews the book, Psychotcopic Drugs by S. Garattini and V. Ghetti (Eds.) (1957). This volume under review is an impressive, competent representation of current work with LSD and many other drugs, consisting of nearly fifty major presentations and an equal number of shorter reports by a total of 169 biochemists, pharmacologists, neurophysiologists, psychologists, and psychiatrists. By and large the book is not one for a reader with a casual interest. There is the protest that the effects of drugs are only superficially similar to more naturally occurring psychopathological changes; but lurking in this proposition lies the implication that experimental modifications of behavior can never really add anything new to existing behavioral theory. The lack of comparable drug experiments with persons represents an omission in the book under review, but the scarcity of such studies in general poses an opportunity and a challenge for both psychology and pharmacology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychotcopic drugs
KW  - pharmacology
KW  - lysergic acid diethylamide
KW  - 1959
KW  - Drugs
KW  - Lysergic Acid Diethylamide
KW  - Pharmacology
KW  - 1959
U2  - Garattini, S. (Ed); Ghetti, V. (Ed). (1957); Psychotcopic Drugs; (Proceedings of the International Symposium on Psychotropic Drugs, Milan, 9-11 May 1957.) Amsterdam: Elsevier Publishing Co., 1957 (distributed by D. Van Nostrand, Princeton, N. J.). Pp. xiv + 606. $19.50
DO  - 10.1037/006067
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05978-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05979-015
AN  - 2006-05979-015
AU  - Birren, James E.
T1  - How Skills Change as Men Mature.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1959/07//
VL  - 4
IS  - 7
SP  - 216
EP  - 218
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05979-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Birren, James E.; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Age Differences; Aging; Skill Learning. Classification: Gerontology (2860). Population: Human (10). Reviewed Item: Welford, A. T. Ageing and Human Skill=New York: Oxford University Press, for the Nuffield Foundation, 1958. Pp vi + 300. $4.00; 1958. Page Count: 3. Issue Publication Date: Jul, 1959. 
AB  - Reviews the book, Ageing and Human Skill by A. T. Welford (see record [rid]1959-05884-000[/rid]). This book brought objectivity and scholarship into the research and thinking on aging and skilled behavior. This book is about aging and skill it is essential for a reviewer to ask what aging and skill meant to author and his staff. It is obvious in the studies that aging did not mean studying old people alone. The experiments included as subjects, adults of all ages, 'young' and 'old.' The word 'skill' may imply to some that author is interested in the things people do with their hands to earn money. The author is interested in skills of livelihood but 'skill' means much more to him, 'skill' is almost synonymous with the ubiquitous 'behavior'. Being predominantly interested in the performance of a task in the present moment, the author does not suggest biological or social manipulation to obviate age differences in performance but the varying of the nature of the tasks. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - skills change
KW  - age differences
KW  - aging
KW  - skilled behavior
KW  - 1959
KW  - Age Differences
KW  - Aging
KW  - Skill Learning
KW  - 1959
U2  - Welford, A. T. (1958); Ageing and Human Skill; New York: Oxford University Press, for the Nuffield Foundation, 1958. Pp vi + 300. $4.00
DO  - 10.1037/006094
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05979-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40222-020
AN  - 2013-40222-020
AU  - Newman, Ruth G.
T1  - The assessment of progress in the treatment of hyperaggressive children with learning disturbances within a school setting.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/07//
VL  - 29
IS  - 3
SP  - 633
EP  - 643
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40222-020. Partial author list: First Author & Affiliation: Newman, Ruth G.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aggressive Behavior; Learning Ability; Teacher Personality; Therapeutic Processes. Minor Descriptor: Schools. Classification: Educational Psychology (3500). Population: Human (10); Male (30). Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Behaviior Scale. Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Jul, 1959. 
AB  - The emphasis in this report was largely placed on those determinants of an incident which arose in part or in whole from the school program itself its methods, materials, subject matter and teacher personality. Although it was observed by this descriptive method that the large majority of the determinants for incidents arose in the personality of the child himself, it was felt that where the school determined the outcome of an incident the data revealed clues concerning the use of material, subject matter, methods and teacher personality. These clues were felt to have implications for the teaching of hyperaggressive children, in general, even outside the more controlled total therapeutic residential setting reported on in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hyperaggressive children
KW  - learning disturbances
KW  - school settings
KW  - therapeutic processes
KW  - teacher personality
KW  - 1959
KW  - Aggressive Behavior
KW  - Learning Ability
KW  - Teacher Personality
KW  - Therapeutic Processes
KW  - Schools
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00231.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40222-020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05980-013
AN  - 2006-05980-013
AU  - Noshpitz, Joseph D.
T1  - The Troublesome Teenager.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1959/08//
VL  - 4
IS  - 8
SP  - 246
EP  - 247
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05980-013. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Noshpitz, Joseph D.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Attitudes; Adolescent Development; Social Sciences. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Bloch, Herbert; Niederhoffer, Arthur. The Gang: A Study in Adolescent Behavior=New York: Philosophical Library, 1958. Pp. xv + 231. $6.00; 1958. Page Count: 2. Issue Publication Date: Aug, 1959. 
AB  - Reviews the book, The Gang: A Study in Adolescent Behavior by Herbert Bloch and Arthur Niederhoffer (see record [rid]1959-00886-000[/rid]). A compact and meaty work that in 219 pages reviews social, cultural, psychological, and anthropological theories of adolescence and delinquency. On the whole, the book is pleasant to read. This reviewer thinks that its weakest element lies in its recommendation that the solution to society's increasing difficulty with its teenagers lies in giving these young people a clearly defined voice in the political activity of the nation-in enfranchising them in some manner. The authors do not merely review literature; they take a stand on many of the current issues in social science and practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adolescent behavior
KW  - adolescent development
KW  - social science
KW  - 1959
KW  - Adolescent Attitudes
KW  - Adolescent Development
KW  - Social Sciences
KW  - 1959
U2  - Bloch, Herbert; Niederhoffer, Arthur. (1958); The Gang: A Study in Adolescent Behavior; New York: Philosophical Library, 1958. Pp. xv + 231. $6.00
DO  - 10.1037/006112
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05980-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39303-007
AN  - 2013-39303-007
AU  - Redl, Fritz
T1  - The concept of a 'therapeutic milieu.'
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1959/10//
VL  - 29
IS  - 4
SP  - 721
EP  - 736
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39303-007. Partial author list: First Author & Affiliation: Redl, Fritz; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Milieu Therapy; Psychotherapeutic Processes; Religious Practices; Therapeutic Community. Minor Descriptor: Geography. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 16. Issue Publication Date: Oct, 1959. 
AB  - This article discusses, that speculations about the therapeutic value of the 'milieu' in which our patients live are neither as new nor as revolutionary as the enthusiasts, as well as the detractors of 'milieu therapy' occasionally want them to appear. The ritual interaction between patient and therapist is certainly sharply circumscribed. Even items such as horizontality of body posture and geographical placement of the analyst's chair are considered important conditions. The cry for the therapeutic milieu as a general slogan is futile and in this wide formulation the term doesn't mean a thing. The worst trap that explorers of the milieu idea sometimes seem to be goaded into is the ubiquitous use of the term 'therapeutic,' if it is coupled as an adjective, with 'milieu'; as a noun. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - therapeutic milieu
KW  - geographical placement
KW  - ritual interaction
KW  - patient and therapist interaction
KW  - 1959
KW  - Milieu Therapy
KW  - Psychotherapeutic Processes
KW  - Religious Practices
KW  - Therapeutic Community
KW  - Geography
KW  - 1959
DO  - 10.1111/j.1939-0025.1959.tb00243.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39303-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05972-012
AN  - 2006-05972-012
AU  - Wispé, Lauren G.
T1  - The Status Motive.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1959/11//
VL  - 4
IS  - 11
SP  - 362
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05972-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wispé, Lauren G.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Industrialization; Social Mobility; Society; Socioeconomic Status. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Lipset, Seymour Martin; Bendix, Reinhard. Social Mobility in Industrial Society=Berkeley: University of California Press, 1959. Pp. xxii + 309 $5 00; 1959. Page Count: 2. Issue Publication Date: Nov, 1959. 
AB  - Reviews the book, Social Mobility in Industrial Society by Seymour Martin Lipset and Reinhard Bendix (1959). This volume is a veritable storehouse of empirical facts about social mobility and of carefully considered interpretations by theorists. These authors define social mobility as the process whereby individuals move from one stratum of society to another because of certain super-social forces like industrialization societies change and the demands made upon the occupants of the various occupational and social roles change. Throughout the social system members find themselves constrained to meet new obligations. Those who defect either through unwillingness or inability, open the way for new incumbents. Unintentional although it may have been, this book reflects the struggle of thousands of men and women to free themselves and their children from the forces of inurement, authority and prejudice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social mobility
KW  - status motive
KW  - industrialization
KW  - industrial society
KW  - 1959
KW  - Industrialization
KW  - Social Mobility
KW  - Society
KW  - Socioeconomic Status
KW  - 1959
U2  - Lipset, Seymour Martin; Bendix, Reinhard. (1959); Social Mobility in Industrial Society; Berkeley: University of California Press, 1959. Pp. xxii + 309 $5 00
DO  - 10.1037/005959
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - The Changing American Parent: A Study in the Detroit Area (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1959/12//
VL  - 24
IS  - 6
M3  - Book Review
SP  - 902
EP  - 903
SN  - 00031224
AB  - Reviews the book "The Changing American Parent: A Study in the Detroit Area,"by Daniel R. Miller and Guy E. Swanson.
KW  - PARENTS
KW  - NONFICTION
KW  - MILLER, Daniel R.
KW  - SWANSON, Guy E.
KW  - CHANGING American Parent: A Study in the Detroit Area, The (Book)
N1  - Accession Number: 12813488; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Dec59, Vol. 24 Issue 6, p902; Subject Term: PARENTS; Subject Term: NONFICTION; Reviews & Products: CHANGING American Parent: A Study in the Detroit Area, The (Book); People: MILLER, Daniel R.; People: SWANSON, Guy E.; Number of Pages: 2p; Document Type: Book Review
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12813488&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-00781-004
AN  - 2006-00781-004
AU  - Mishkin, Mortimer
AU  - Weiskrantz, Lawrence
T1  - Effects of cortical lesions in monkeys on critical flicker frequency.
JF  - Journal of Comparative and Physiological Psychology
JO  - Journal of Comparative and Physiological Psychology
JA  - J Comp Physiol Psychol
Y1  - 1959/12//
VL  - 52
IS  - 6
SP  - 660
EP  - 666
CY  - US
PB  - American Psychological Association
SN  - 0021-9940
N1  - Accession Number: 2006-00781-004. Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Mishkin, Mortimer; Laboratory of Psychology, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Cortex; Critical Flicker Fusion Threshold; Monkeys. Classification: Animal Experimental & Comparative Psychology (2400); Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 1959. Copyright Statement: American Psychological Association. 1959. 
AB  - The critical flicker frequencies of 12 monkeys were determined by a modified 'method of limits' before and after various cortical ablations. The results confirmed the prediction, based on studies of other visual functions in monkeys, that CFF in this species would not be impaired by anterior frontal lesions, but would be impaired by both inferotemporal and lateral occipital lesions. These findings are compared with the results of investigations of CFF in brain-injured men. Certain characteristics of the animals' performance provided evidence of the important influence of learning on the CFF. It is suggested that occipital and temporal lesions may have had deceptively similar effects on this function by interfering with sensory and learning mechanisms, respectively. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cortical lesions
KW  - flicker frequency
KW  - monkeys
KW  - 1959
KW  - Cerebral Cortex
KW  - Critical Flicker Fusion Threshold
KW  - Monkeys
KW  - 1959
DO  - 10.1037/h0038577
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00781-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Heller, John R.
T1  - Recent developments in research on cancer.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1960/01//
VL  - 15
IS  - 1
M3  - Article
SP  - 1
EP  - 10
SN  - 0016867X
N1  - Accession Number: 20789589; Heller, John R. 1,2; Source Information: Jan1960, Vol. 15 Issue 1, p1; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 1 Diagram, 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 4107
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - CHAP
ID  - 2013-25223-003
AN  - 2013-25223-003
AU  - Alexander, Irving E.
AU  - Adlerstein, Arthur M.
ED  - David, Henry P.
ED  - Brengelmann, J. C.
ED  - David, Henry P., (Ed)
ED  - Brengelmann, J. C., (Ed)
T1  - Studies in the psychology of death.
T2  - Perspectives in personality research.
Y1  - 1960///
SP  - 65
EP  - 92
CY  - New York, NY, US
PB  - Springer Publishing Co
N1  - Accession Number: 2013-25223-003. Partial author list: First Author & Affiliation: Alexander, Irving E.; Training Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20131028. Correction Date: 20140512. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Death and Dying; Psychology. Classification: Personality Traits & Processes (3120). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Tucker Goals of Life Inventory; Cattell Manifest Anxiety Scale; Word Association Task; Rotter Incomplete Sentences Blank. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 28. 
AB  - Each man learns early in life that some day he must die. What role does this information play in his development? How does it affect his aims, his wishes, his behavior? At the present time our best sources of information on these questions are outside the field of psychology—in literature, philosophy, religion, and medicine. While such sources have yielded rich insights about the meaning that death has for human beings, there has been little attempt to apply scientific procedures to select among these ideas. Perhaps it is time for this further step to be taken. It is the purpose of this chapter to describe some primitive attempts, utilizing the more traditional techniques and methods of our science, to study some aspects of man's reaction to death. First let us glance briefly at the state of our knowledge about death as it exists in the psychological literature. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychology
KW  - death
KW  - 1960
KW  - Death and Dying
KW  - Psychology
KW  - 1960
U1  - Sponsor: National Institute of Mental Health, US. Recipients: No recipient indicated
DO  - 10.1037/14410-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-25223-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 1960-08158-004
AN  - 1960-08158-004
AU  - Kety, Seymour S.
ED  - Jackson, Don D.
ED  - Jackson, Don D., (Ed)
T1  - Recent Biochemical Theories of Schizophrenia.
T2  - The etiology of schizophrenia.
Y1  - 1960///
SP  - 120
EP  - 145
CY  - Oxford, England
PB  - Basic Books
N1  - Accession Number: 1960-08158-004. Partial author list: First Author & Affiliation: Kety, Seymour S.; Laboratory of Clinical Science, National Institute of Mental Health, US. Release Date: 19600501. Publication Type: Book (0200). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Biochemistry; Schizophrenia; Theories. Minor Descriptor: Etiology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26. 
AB  - The concept of a chemical etiology in schizophrenia is not new. Earlier biochemical theories and findings related to schizophrenia have been reviewed by a number of authors. It is the purpose of this review to describe the biochemical trends in schizophrenia research of the past few years, to discuss current theories, and to examine the evidence that has been used to support them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia research
KW  - biochemical theories
KW  - 1960
KW  - Biochemistry
KW  - Schizophrenia
KW  - Theories
KW  - Etiology
KW  - 1960
DO  - 10.1037/10605-004
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-08158-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41274-011
AN  - 2013-41274-011
AU  - Dittmann, Allen T.
T1  - The psychotherapeutic function of the orthopsychiatric team: Report of the Committee on Psychotherapy: Panel, 1959: 6. The need for ongoing research in the general function of the orthopsychiatric team.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1960/01//
VL  - 30
IS  - 1
SP  - 79
EP  - 86
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41274-011. Partial author list: First Author & Affiliation: Dittmann, Allen T.; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinics; Health Care Services; Orthopsychiatry; Psychotherapy. Minor Descriptor: Teams. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 8. Issue Publication Date: Jan, 1960. 
AB  - This article speculate on what we should do next in trying to find out how psychotherapy is practiced in clinics throughout the country. To my mind the trouble with the work we've done so far is that it has been successful in giving us some partial answers to our questions. The final report is extensive, carefully thought out, and bears rereading, or first reading, as the case may be. From the standpoint of our present discussion, however, it is the contrast between the visits and the questionnaire. The findings of a survey about psychotherapy in orthopsychiatric clinics, then, would have widespread interest not only to our organization, but to the professions which our members represent. This interest, of course, is our interest in the long run, and it would be well if it could be served with data which can be taken seriously. The time has passed when hunches, hearsay and opinion about orthopsychiatric practice can suffice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - orthopsychiatric teams
KW  - ongoing research
KW  - clinics
KW  - health services
KW  - psychotherapy
KW  - 1960
KW  - Clinics
KW  - Health Care Services
KW  - Orthopsychiatry
KW  - Psychotherapy
KW  - Teams
KW  - 1960
DO  - 10.1111/j.1939-0025.1960.tb03012.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41274-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Campbell, John D.
T1  - The Psychology of Affiliation: Experimental Studies of the Sources of Gregariousness (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1960/02//
VL  - 25
IS  - 1
M3  - Book Review
SP  - 130
EP  - 131
SN  - 00031224
AB  - Reviews the book "The Psychology of Affiliation: Experimental Studies of the Sources of Gregariousness," by Stanley Schachter.
KW  - SOCIAL isolation
KW  - NONFICTION
KW  - SCHACHTER, Stanley
KW  - PSYCHOLOGY of Affiliation: Experimental Studies of the Sources of Gregariousness, The (Book)
N1  - Accession Number: 12785989; Campbell, John D. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Feb60, Vol. 25 Issue 1, p130; Subject Term: SOCIAL isolation; Subject Term: NONFICTION; Reviews & Products: PSYCHOLOGY of Affiliation: Experimental Studies of the Sources of Gregariousness, The (Book); People: SCHACHTER, Stanley; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Birren, James E.
T1  - PSYCHOLOGICAL ASPECTS OF AGING.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1960/02//
VL  - 11
IS  - 1
M3  - Article
SP  - 161
EP  - 198
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Focuses on the psychological aspects of aging. Analysis of socio-cultural influences on aging; Significance of health surveys of the older adults; Interpretation of neuropsychological factors in relation to psychiatric disturbances.
KW  - AGING -- Psychological aspects
KW  - NEUROPHYSIOLOGY
KW  - HEALTH surveys
KW  - PSYCHOPHYSIOLOGY
N1  - Accession Number: 11266867; Birren, James E. 1; Affiliations: 1: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1960, Vol. 11 Issue 1, p161; Subject Term: AGING -- Psychological aspects; Subject Term: NEUROPHYSIOLOGY; Subject Term: HEALTH surveys; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 38p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rubenstein, Herbert
AU  - Aborn, Murray
T1  - PSYCHOLINGUISTICS.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1960/02//
VL  - 11
IS  - 1
M3  - Article
SP  - 291
EP  - 322
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Focuses on various aspects of psycholinguistics. Relationship between the probability of language segments and behaviors; Significance of word association in common language experience; Importance of equipments for analyzing and synthesizing speech.
KW  - PSYCHOLINGUISTICS
KW  - HUMAN behavior
KW  - LANGUAGE & languages
KW  - SPEECH
N1  - Accession Number: 11267426; Rubenstein, Herbert 1; Aborn, Murray 2; Affiliations: 1: Operational Applications Laboratory, Air Forte Cambridge Research Center, Bedford, Massachusetts.; 2: Division of Research Grants, National  Institutes of Health, Bethesda, Maryland.; Issue Info: 1960, Vol. 11 Issue 1, p291; Subject Term: PSYCHOLINGUISTICS; Subject Term: HUMAN behavior; Subject Term: LANGUAGE & languages; Subject Term: SPEECH; Number of Pages: 32p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Ross, Sherman
AU  - Cole, Jonathan 0.
T1  - PSYCHOPHARMACOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1960/02//
VL  - 11
IS  - 1
M3  - Article
SP  - 415
EP  - 438
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Focuses on the efforts of developments in psychopharmacology. Role of traditional drugs in clinical treatment; Significance of psychotomimetic agents in psychiatric treatment; Effects of these drugs on human behavior.
KW  - RESEARCH
KW  - PSYCHOPHARMACOLOGY
KW  - PSYCHIATRIC drugs
KW  - HUMAN behavior
N1  - Accession Number: 11267444; Ross, Sherman 1; Cole, Jonathan 0. 2; Affiliations: 1: University of  Maryland, College Park, Maryland.; 2: Psychopharmacology Service center, National  Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1960, Vol. 11 Issue 1, p415; Thesaurus Term: RESEARCH; Subject Term: PSYCHOPHARMACOLOGY; Subject Term: PSYCHIATRIC drugs; Subject Term: HUMAN behavior; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-05987-009
AN  - 2006-05987-009
AU  - Singer, Jerome L.
T1  - What Do We Know of Projective Techniques?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1960/03//
VL  - 5
IS  - 3
SP  - 76
EP  - 77
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05987-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Singer, Jerome L.; National Institute of Mental Health, US. Release Date: 20061023. Correction Date: 20120409. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Personality Change; Personality Development; Projective Techniques. Classification: Personality Psychology (3100). Population: Human (10). Reviewed Item: Harrower, Molly. Personality Change and Development: As Measured by the Projective Techniques=New York: Grune & Stratton, 1958. Pp. 383. $10.00; 1958. Page Count: 2. Issue Publication Date: Mar, 1960. 
AB  - Reviews the book, Personality Change and Development: As Measured by the Projective Techniques by Molly Harrower (see record [rid]2008-13301-000[/rid]). Do projective techniques actually reflect personality changes otherwise observable through life adjustment or from therapists' evaluations? Dr. Molly Harrower has sought at least an approach to answering some of the cogent queries which she poses at the outset of her new book. The Summary was obviously developed with considerable awareness of the dimensions which are relevant to psychotherapists and which can therefore, with slight modifications, be also employed for obtaining independent evaluations by therapists. Dr. Harrower goes on to note the rather striking fluctuations in responses upon successive testing but provides some clinical illustrations of both quantitative and configurational similarity in the records. The main body of this volume deals with comparisons of pretesting and posttesting and Test Summary Scores. While Dr. Harrower's conclusions will not be too surprising to most experienced clinicians, there is the danger that they may be too encouraging, as the author herself notes. Dr Harrower has raised some cogent issues and has indeed pointed to certain techniques and methods for answering these questions, even though her own data fail to yield conviction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - projective techniques
KW  - personality changes
KW  - personality development
KW  - 1960
KW  - Personality Change
KW  - Personality Development
KW  - Projective Techniques
KW  - 1960
U2  - Harrower, Molly. (1958); Personality Change and Development: As Measured by the Projective Techniques; New York: Grune & Stratton, 1958. Pp. 383. $10.00
DO  - 10.1037/006254
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05987-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40224-002
AN  - 2013-40224-002
AU  - Bell, Richard Q.
AU  - Garmezy, Norman
AU  - Farina, Amerigo
AU  - Rodnick, Eliot. H.
T1  - Direct study of child-parent interactions: Workshop, 1959: 1. The structured situational test: A method for studying family interaction in schizophrenia.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1960/07//
VL  - 30
IS  - 3
SP  - 445
EP  - 452
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40224-002. Partial author list: First Author & Affiliation: Bell, Richard Q.; Laboratory of Psychology, National Institutes of Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Psychology; Collaboration; Schizophrenia. Minor Descriptor: Family; Parents. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1960. 
AB  - The purpose of this paper is to present data obtained from a study of parents of schizophrenic patients in which a technique was employed-the structured situational test-to circumvent many of the difficulties which have been described. This method involves the observation of actual behavior in response to uniform stimulus situations. The situations which are kept open-ended, provide for a wide range of behavior variation and disguise of what is being measured. This last point is particularly important in view of the reported defensiveness of parents of schizophrenic patients. Nevertheless, the study of parent-patient interaction is a necessary future step. The decision to embark upon such research will, however, require appropriate institutional safeguards. The investigator in this area should possess an amalgam of clinical maturity, experimental sophistication and breadth of experience in psychopathology. It is in this experimental area of the systematic study of parent patient interaction that the collaborative efforts of the sophisticated psychotherapist and the equally sophisticated experimentalist may prove most fruitful. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child-parent interactions
KW  - clinical maturity
KW  - collaborative efforts
KW  - parent-patient interaction
KW  - schizophrenic patients
KW  - 1960
KW  - Clinical Psychology
KW  - Collaboration
KW  - Schizophrenia
KW  - Family
KW  - Parents
KW  - 1960
U1  - Sponsor: National Institute of Mental Health, US. Grant: M-629. Recipients: No recipient indicated
DO  - 10.1111/j.1939-0025.1960.tb02060.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40224-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40224-016
AN  - 2013-40224-016
AU  - Newman, Ruth
T1  - The way back: Extramural schooling as a transitional phase of residential therapy.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1960/07//
VL  - 30
IS  - 3
SP  - 588
EP  - 598
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40224-016. Partial author list: First Author & Affiliation: Newman, Ruth; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Ego; Residential Care Institutions; Therapeutic Processes. Minor Descriptor: Emotional Disturbances; Schools. Classification: Educational Psychology (3500). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Jul, 1960. 
AB  - This report is concerned with a transitional phase in the treatment of children who have been institutionalized because of severe behavioral and emotional disturbances. There arrives a time when a confined environment is neither necessary nor beneficial. At this point, the children need a carefully planned expansion of their lives while they still remain in a protective, therapeutic environment. Thus, their response to the increasing demands of their widened horizon can be handled, investigated and treated. School is society for a child. I t is his work life, a barometer of his ego strengths and weaknesses. Therefore, a major aspect of the transitional treatment phase consists in the selection of appropriate schools ; the working out of methods for helping a child to maintain himself constructively in school as well as to recognize and cope with the anxiety engendered and the problems that arise. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - extramural schooling
KW  - ego strengths
KW  - emotional disturbances
KW  - residential therapy
KW  - therapeutic environment
KW  - transitional treatment phase
KW  - 1960
KW  - Ego
KW  - Residential Care Institutions
KW  - Therapeutic Processes
KW  - Emotional Disturbances
KW  - Schools
KW  - 1960
DO  - 10.1111/j.1939-0025.1960.tb02074.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40224-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
T1  - DISTANCE AND CONFORMITY IN CONTINUOUS SOCIAL INFLUENCE INTERACTIONS.
AU  - Zolman, James F.
AU  - Wolf, Irvin S.
AU  - Fisher, Seymour
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1960/08//
VL  - 52
IS  - 2
SP  - 251
EP  - 258
SN  - 00224545
N1  - Accession Number: 16520648; Author: Zolman, James F.: 1 Author: Wolf, Irvin S.: 1 Author: Fisher, Seymour: 1 ; Author Affiliation: 1 Denison University and the National Institute of Mental Health.; No. of Pages: 8; Language: English; Publication Type: Article; Update Code: 20050325
N2  - The article focuses on distance and conformity in continuous social influence interactions. An experiment was carried out, which was a continuation of research aimed at specifying the relations between measures of social influence (movement and conformity) and distance (size of discrepancy) in continuous social interaction situations. Pairs of "Ss" were required to judge the number of paratroopers seen in two successively exposed photographs. By manipulating the amount of intertrial influence between the two photographs, it was possible to vary experimentally the distance each of three groups received on the second photograph. The results indicate that movement and conformity in a second interaction are contingent upon distance as in the initial interaction. \Within the distance range covered, in both interactions conformity was found to be a decreasing monotonic function of distance.
KW  - *SOCIAL psychology
KW  - SOCIAL influence
KW  - CONFORMITY
KW  - PHOTOGRAPHS
KW  - SOCIAL interaction
KW  - PRESTIGE
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
AU  - Butler, Robert N.
T1  - Intensive psychotherapy for the hospitalized aged.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1960/09//
VL  - 15
IS  - 9
M3  - Article
SP  - 644
EP  - 653
SN  - 0016867X
N1  - Accession Number: 20879016; Butler, Robert N. 1,2; Source Information: Sep1960, Vol. 15 Issue 9, p644; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 5071
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20879016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Dorn, Harold F.
T1  - The Influence of Non-Govermental Groups on Foreign Policy-Making/Americans in World Affairs/Opinion Leaders in American Communities.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1960/10//
VL  - 25
IS  - 5
M3  - Book Review
SP  - 776
EP  - 777
SN  - 00031224
AB  - Reviews two books about foreign affairs. "The Influence of Non-Govermental Groups on Foreign Policy-Making," by Bernard C. Cohen, foreword by Max F. Millikan; "Americans in World Affairs," by Alfred O. Hero, foreword by Max F. Millikan; "Opinion Leaders in American Communities," by Alfred O. Hero, foreword by Max F. Millikan.
KW  - INTERNATIONAL relations
KW  - NONFICTION
KW  - COHEN, Bernard C.
KW  - MILLIKAN, Max F.
KW  - HERO, Alfred O.
KW  - INFLUENCE of Non-Govermental Groups on Foreign Policy-Making, The (Book)
KW  - AMERICANS in World Affairs (Book)
KW  - OPINION Leaders in American Communities (Book)
N1  - Accession Number: 12801202; Dorn, Harold F. 1; Affiliations: 1: National Institutes of Health; Issue Info: Oct60, Vol. 25 Issue 5, p776; Thesaurus Term: INTERNATIONAL relations; Subject Term: NONFICTION; Reviews & Products: INFLUENCE of Non-Govermental Groups on Foreign Policy-Making, The (Book); Reviews & Products: AMERICANS in World Affairs (Book); Reviews & Products: OPINION Leaders in American Communities (Book); NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 911410 Foreign affairs; People: COHEN, Bernard C.; People: MILLIKAN, Max F.; People: HERO, Alfred O.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Dorn, Harold F.
T1  - Elements of Vital Statistics.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1960/10//
VL  - 25
IS  - 5
M3  - Book Review
SP  - 777
EP  - 777
SN  - 00031224
AB  - Reviews the book "Elements of Vital Statistics," by Bernard Benjamin.
KW  - VITAL statistics
KW  - NONFICTION
KW  - BENJAMIN, Bernard
KW  - ELEMENTS of Vital Statistics (Book)
N1  - Accession Number: 12801203; Dorn, Harold F. 1; Affiliations: 1: National Institutes of Health; Issue Info: Oct60, Vol. 25 Issue 5, p777; Thesaurus Term: VITAL statistics; Subject Term: NONFICTION; Reviews & Products: ELEMENTS of Vital Statistics (Book); People: BENJAMIN, Bernard; Number of Pages: 2/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-05984-010
AN  - 2006-05984-010
AU  - Dittmann, Allen T.
T1  - Systematic Psychoanalysis as Research.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1960/11//
VL  - 5
IS  - 11
SP  - 366
EP  - 367
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05984-010. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Dittmann, Allen T.; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychoanalysis; Psychodynamics; Psychotherapy. Minor Descriptor: Mental Disorders; Psychosis; Schizophrenia. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Bullard, Dexter M. (Ed). Psychoanalysis and Psychotherapy: Selected Papers of Frieda Fromm-Reichmann=Chicago: University of Chicago Press, 1959. Pp. xiv + 350. $7.50; 1959. Page Count: 2. Issue Publication Date: Nov, 1960. 
AB  - Reviews the book, Psychoanalysis and Psychotherapy: Selected Papers of Frieda Ftomm- Reichmann edited Dexter M. Bullard (see record [rid]1960-04550-000[/rid]). This book is a selection of 23 of Fromm-Reichmann's papers published between 1935 and 1959 which treats among other subjects: (a) the philosophy of mental disorder and the history and philosophy of psychotherapy; (b) the problems and advances in psychoanalysis and psychotherapy with psychotics; (c) the psychodynamics and therapy of schizophrenia. This book was compiled by her colleagues, friends, and students as an expression of their wish 'to preserve and concentrate Frieda Fromm-Reichmann's thoughts and ideas.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychoanalysis
KW  - psychotherapy
KW  - mental disorder
KW  - psychotics
KW  - psychodynamics
KW  - schizophrenia
KW  - 1960
KW  - Psychoanalysis
KW  - Psychodynamics
KW  - Psychotherapy
KW  - Mental Disorders
KW  - Psychosis
KW  - Schizophrenia
KW  - 1960
U2  - Bullard, Dexter M. (Ed). (1959); Psychoanalysis and Psychotherapy: Selected Papers of Frieda Fromm-Reichmann; Chicago: University of Chicago Press, 1959. Pp. xiv + 350. $7.50
DO  - 10.1037/006205
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05984-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Caudill, William
T1  - The Culture of the State Mental Hospital (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1960/12//
VL  - 25
IS  - 6
M3  - Book Review
SP  - 981
EP  - 981
SN  - 00031224
AB  - Reviews the book "The Culture of the State Mental Hospital," by H. Warren Dunham and S. Kirson Weinberg.
KW  - PSYCHIATRIC hospitals
KW  - NONFICTION
KW  - DUNHAM, H. Warren
KW  - WEINBERG, S. Kirson
KW  - CULTURE of the State Mental Hospital, The (Book)
N1  - Accession Number: 12875448; Caudill, William 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Dec60, Vol. 25 Issue 6, p981; Thesaurus Term: PSYCHIATRIC hospitals; Subject Term: NONFICTION; Reviews & Products: CULTURE of the State Mental Hospital, The (Book); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; People: DUNHAM, H. Warren; People: WEINBERG, S. Kirson; Number of Pages: 3/4p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2013-40694-004
AN  - 2013-40694-004
AU  - Dysinger, Robert H.
T1  - The family as the unit of study and treatment: Workshop, 1959: 2. A family perspective on the diagnosis of individual members.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1961/01//
VL  - 31
IS  - 1
SP  - 61
EP  - 68
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40694-004. Partial author list: First Author & Affiliation: Dysinger, Robert H.; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diagnosis; Emotional Disturbances; Family Therapy; Psychosis. Minor Descriptor: Individualism; Parental Attitudes; Treatment. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 8. Issue Publication Date: Jan, 1961. 
AB  - The observations described here may be used as a basis for venturing one kind of statement that would attempt to recognize the problem at a family level. Could it be that the situation is something like this? An intense emotional problem in the parental relationship has long been handled through a complicated and subtle set of mechanisms that operate to support an inaccurate assumption and action consistent with it that this problem is one of the health of one child. The inefficiency of this chronic displacement as a mode of family adjustment becomes openly manifest with the development of the psychosis. At the same time the psychosis lends itself to being seen as a living confirmation of the accuracy of the assumption, and can become a focus for the perpetuation of the family mechanism. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment units
KW  - family
KW  - individual members
KW  - diagnosis
KW  - parental relationships
KW  - emotional problems
KW  - psychosis
KW  - 1961
KW  - Diagnosis
KW  - Emotional Disturbances
KW  - Family Therapy
KW  - Psychosis
KW  - Individualism
KW  - Parental Attitudes
KW  - Treatment
KW  - 1961
DO  - 10.1111/j.1939-0025.1961.tb02107.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40694-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40694-006
AN  - 2013-40694-006
AU  - Basamania, Betty W.
T1  - The family as the unit of study and treatment: Workshop, 1959: 4. The emotional life of the family: Inferences for social casework.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1961/01//
VL  - 31
IS  - 1
SP  - 74
EP  - 86
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40694-006. Partial author list: First Author & Affiliation: Basamania, Betty W.; Family Study Section, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Adjustment; Family Relations; Family Therapy; Treatment. Minor Descriptor: Diagnosis; Social Casework. Classification: Group & Family Therapy (3313). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. Page Count: 13. Issue Publication Date: Jan, 1961. 
AB  - This paper will present a casework view of the project’s particular approach to the family as a unit to illustrate the contribution such an approach can make toward the diagnosis and treatment of that unit. The approach was to regard the family unit as a single organism. In the following sections there will be a discussion of observations made as a result of seeing the family together, treatment of the family unit, and the inferences this approach has for social casework. Observations included in this paper were selected on the basis of repetitive behavior manifestations, seen in each of the 11 families. The characteristics noted as significant within the families were also experienced by the staff in relating to the families. The observations were made as a result of seeing the family as a unit, and would have been much less clear, if not obscured, if family members had been seen individually. These observations were not all-inclusive of the data of this study but were outstanding in the effort to understand the functioning of these families with a particular kind of problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment processes
KW  - emotional life
KW  - family dynamics
KW  - diagnosis
KW  - family therapy
KW  - social work
KW  - 1961
KW  - Emotional Adjustment
KW  - Family Relations
KW  - Family Therapy
KW  - Treatment
KW  - Diagnosis
KW  - Social Casework
KW  - 1961
DO  - 10.1111/j.1939-0025.1961.tb02109.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40694-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Mohler, Stanley R.
T1  - Aging and pilot performance.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1961/02//
VL  - 16
IS  - 2
M3  - Article
SP  - 82
EP  - 88
SN  - 0016867X
N1  - Accession Number: 17810157; Mohler, Stanley R. 1; Source Information: Feb1961, Vol. 16 Issue 2, p82; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3287
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Caudill, William
T1  - AROUND THE CLOCK PATIENT CARE IN JAPANESE PSYCHIATRIC HOSPITALS: THE ROLE OF THE TSUKISOI.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1961/04//
VL  - 26
IS  - 2
M3  - Article
SP  - 204
EP  - 214
SN  - 00031224
AB  - Tsukisoi are sub-professional nurses who, in private psychiatric hospitals in Japan, are assigned on a one-to-one basis to patients. The tsukisoi cares for the patient continuously throughout his hospitalization. The work of this role group and its place in the social structure of the hospital are described. Correspondences are drawn between the behavior of the tsukisoi in her technical role and the behavior exhibited in more general roles, such as that of mother, in Japanese culture. The position of the tsukisoi in the power structure of the hospital is seen in relation to the structure of power groupings in organizations such as the Japanese company or factory. Some of the wider sociological and psychodynamic implications of the role of the tsukisoi are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NURSES
KW  - PSYCHIATRIC hospitals
KW  - HOSPITAL care
KW  - PATIENTS
KW  - PSYCHODYNAMICS
KW  - JAPAN
N1  - Accession Number: 12768725; Caudill, William 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Apr61, Vol. 26 Issue 2, p204; Thesaurus Term: NURSES; Thesaurus Term: PSYCHIATRIC hospitals; Subject Term: HOSPITAL care; Subject Term: PATIENTS; Subject Term: PSYCHODYNAMICS; Subject: JAPAN; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - The Social Epidemiology of Mental Disorders--A Psychiatric Survey of Texas.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1961/06//
VL  - 26
IS  - 3
M3  - Book Review
SP  - 493
EP  - 494
SN  - 00031224
AB  - Reviews the book "The Social Epidemiology of Mental Disorders--A Psychiatric Survey of Texas," by E. Gartly Jaco.
KW  - MENTAL illness
KW  - NONFICTION
KW  - JACO, E. Gartly
KW  - SOCIAL Epidemiology of Mental Disorders: A Psychiatric Survey of Texas, The (Book)
N1  - Accession Number: 12785835; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Jun61, Vol. 26 Issue 3, p493; Subject Term: MENTAL illness; Subject Term: NONFICTION; Reviews & Products: SOCIAL Epidemiology of Mental Disorders: A Psychiatric Survey of Texas, The (Book); People: JACO, E. Gartly; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-06025-005
AN  - 2006-06025-005
AU  - Bergman, Paul
T1  - Has Psychoanalysis Become Too Complacent?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1961/08//
VL  - 6
IS  - 8
SP  - 265
EP  - 266
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06025-005. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; Laboratory of Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Curriculum; Psychoanalysis; Psychoanalytic Training. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Reviewed Item: Lewin, Bertram D.; Ross, Helen. Psychoanalytic Education in the United States=New York: W. W. Norton, 1960. Pp. xviii + 478. $10.00; 1960. Page Count: 2. Issue Publication Date: Aug, 1961. 
AB  - Reviews the book, Psychoanalytic Education in the United States by Bertram D. Lewin and Helen Ross (see record [rid]1961-06514-000[/rid]). If you are interested in critical comment on current practices, you will find that, up to a certain point the authors' report within local groups, habits of thinking which they consider all too empirical, they are not satisfied with the conformity and the lack of clarity which they see at times, they decry the scarcity of creative freedom in teaching. On the other hand, they think that 'it is evident that it is now known what should be covered' in the curriculum. At any rate, the authors do not point to the desirability of judging psychoanalytic education by how effectively it prepares for the business of therapy. The magic circle of that spirit seems also to have captivated the authors of this book. Wholly preoccupied with the technicalities of training psychoanalysts, they neglect to take a bearing on the values toward which the endeavor should be guided. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychoanalysis
KW  - psychoanalytic education
KW  - curriculum
KW  - US
KW  - 1961
KW  - Curriculum
KW  - Psychoanalysis
KW  - Psychoanalytic Training
KW  - 1961
U2  - Lewin, Bertram D.; Ross, Helen. (1960); Psychoanalytic Education in the United States; New York: W. W. Norton, 1960. Pp. xviii + 478. $10.00
DO  - 10.1037/006669
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06025-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Suster, E.
AU  - Kirsanow, Eugene M.
T1  - Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions.
JO  - Immunology
JF  - Immunology
Y1  - 1961/10//
VL  - 4
IS  - 4
M3  - Article
SP  - 354
EP  - 365
SN  - 00192805
AB  - In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms. Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37RV or Vallée. The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDOTOXINS
KW  - IMMUNE response
KW  - MYCOBACTERIA
KW  - BACTERIAL toxins
KW  - ANTIGEN-antibody reactions
KW  - MICE as carriers of disease
KW  - IMMUNOLOGY
N1  - Accession Number: 12534120; Suster, E. 1,2; Kirsanow, Eugene M. 1,2; Source Information: Oct61, Vol. 4 Issue 4, p354; Subject: ENDOTOXINS; Subject: IMMUNE response; Subject: MYCOBACTERIA; Subject: BACTERIAL toxins; Subject: ANTIGEN-antibody reactions; Subject: MICE as carriers of disease; Subject: IMMUNOLOGY; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2006-00786-007
AN  - 2006-00786-007
AU  - Stricker, George
T1  - Word values, word frequency, and visual duration thresholds: A comment.
JF  - Psychological Review
JO  - Psychological Review
JA  - Psychol Rev
Y1  - 1961/11//
VL  - 68
IS  - 6
SP  - 420
EP  - 422
CY  - US
PB  - American Psychological Association
SN  - 0033-295X
SN  - 1939-1471
N1  - Accession Number: 2006-00786-007. Partial author list: First Author & Affiliation: Stricker, George; National Institute of Mental Health, United States Public Health Service, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Semantic Differential; Thresholds; Visual Acuity; Word Frequency. Minor Descriptor: Words (Phonetic Units). Classification: Human Experimental Psychology (2300). References Available: Y. Page Count: 3. Issue Publication Date: Nov, 1961. Copyright Statement: American Psychological Association. 1961. 
AB  - Comments on an article by Johnson, Thomson, and Frincke (see record [rid]2005-10341-002[/rid]). Johnson, Thomson, and Frincke's interpretation of their work with regard to the interrelationships of word value and word frequency was questioned on the basis of their use of the good-bad scale of the semantic differential as an operational definition of word value. Reference to pertinent previous studies seemed to indicate that word value has a directly motivational connotation while the evaluative dimension of the semantic differential is sensitive to an attitudinal, cognitive component of behavior. An examination of their interpretations of their experimental evidence revealed a failure to take this distinction into account. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - word values
KW  - word frequency
KW  - visual duration thresholds
KW  - interrelationships
KW  - semantic differential
KW  - 1961
KW  - Semantic Differential
KW  - Thresholds
KW  - Visual Acuity
KW  - Word Frequency
KW  - Words (Phonetic Units)
KW  - 1961
DO  - 10.1037/h0039126
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00786-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
T1  - Variations in Value Orientations.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1961/12//
VL  - 26
IS  - 6
M3  - Book Review
SP  - 936
EP  - 937
SN  - 00031224
AB  - Reviews the book "Variations in Value Orientations," by Florence Rockwood Kluchhohn and Fred L. Strodtbeck.
KW  - SOCIAL values
KW  - NONFICTION
KW  - STRODTBECK, Fred L.
KW  - KLUCHHOHN, Florence
KW  - VARIATIONS in Value Orientations (Book)
N1  - Accession Number: 12819628; Rosenberg, Morris 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Dec61, Vol. 26 Issue 6, p936; Subject Term: SOCIAL values; Subject Term: NONFICTION; Reviews & Products: VARIATIONS in Value Orientations (Book); People: STRODTBECK, Fred L.; People: KLUCHHOHN, Florence; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Pearlin, Leonard I.
T1  - THE APPEALS OF ANONYMITY IN QUESTIONNAIRE RESPONSE.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1961///Winter61/62
VL  - 25
IS  - 4
M3  - Article
SP  - 640
EP  - 647
SN  - 0033362X
AB  - The circulation of questionnaires to strangers always involves a mixture of etiquette and expediency. Here is a study which challenges the usual assumption that the questionnaires must remain anonymous to ensure candidness and enhance the validity of the responses. However, it points out that the preservation of anonymity may be advantageous for other reasons. It has become standard practice in much social and psychological research to guarantee anonymity to respondents. This is easily done where respondent identification is not needed. Offering safeguards of anonymity to respondents is common in social and psychological research. Anonymity is extended to ensure a high level of voluntary participation or, where participation is mandatory, to minimize haloed and invalid responses. In each case, the assumption is made that there are questions which, if answered candidly, would place respondents in a position of fear and worry. People who held positive opinions on presumably fear-arousing issues were no more likely to sign than those who held negative opinions. Anonymity can derive from social and personal characteristics of respondents as well as from the character of the questions that are asked.
KW  - Questionnaires
KW  - Etiquette
KW  - Social participation
KW  - Conduct of life
KW  - Psychology -- Research
N1  - Accession Number: 11962217; Pearlin, Leonard I. 1; Affiliations: 1: Social Science Analyst, staff of Laboratory of Socio-environmental Studies, National Institute of Mental Health.; Issue Info: Winter61/62, Vol. 25 Issue 4, p640; Thesaurus Term: Questionnaires; Subject Term: Etiquette; Subject Term: Social participation; Subject Term: Conduct of life; Subject Term: Psychology -- Research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - 
AU  - Kagan, Jerome1
AU  - Moss, Howard A.2
T1  - Personality and Social Development: Family and Peer Influences.
JO  - Review of Educational Research
JF  - Review of Educational Research
J1  - Review of Educational Research
PY  - 1961/12//
Y1  - 1961/12//
VL  - 31
IS  - 5
CP  - 5
M3  - Article
SP  - 463
EP  - 474
SN  - 00346543
AB  - This article identifies the consideration of the research in the long-term stability of selected behaviors and will continue with a discussion of the influence of parents and peers on the behavior of the child and the adolescent. Suggested that dependent behavior violated sex-role standards for males and that dependent boys learned to inhibit the behavior as they matured. A dependent posture was more congruent with traditional female sex-role standards and the dependent girl was not highly pressured into inhibiting the response. It also identified the degree of adoption of traditional masculine or feminine sex-role interests among adolescent boys.
KW  - Teenagers
KW  - Behavior
KW  - Parents
KW  - Children -- Attitudes
KW  - Gender role
KW  - Teenage boys
N1  - Accession Number: 18812150; Authors: Kagan, Jerome 1; Moss, Howard A. 2; Affiliations:  1: Fels Research Institute, Yellow Springs, Ohio;  2: National Institute of Mental Health, Bethesda, Maryland; Subject: Behavior; Subject: Parents; Subject: Children -- Attitudes; Subject: Gender role; Subject: Teenage boys; Subject: Teenagers; Number of Pages: 12p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - 
AU  - Birren, James F.1
AU  - Jerome, Edward A.1
AU  - Chown, Sheila M.2
T1  - Aging and Psychological Adjustment: Problem Solving and Motivation.
JO  - Review of Educational Research
JF  - Review of Educational Research
J1  - Review of Educational Research
PY  - 1961/12//
Y1  - 1961/12//
VL  - 31
IS  - 5
CP  - 5
M3  - Article
SP  - 487
EP  - 499
SN  - 00346543
AB  - This article focuses on the development psychology of the aging. Its primary objective was to integrate information and explain the manifest changes which occur in the aging individual. Reviewed the aspects of the aging individual as sensation and perception, emotions, learning, intelligence, interests and attitudes, personality and adjustment. Research in the use of leisure. The trend toward intellectual and expressive sophistication in free-time activity on the part of educators to what happens to the young people they educate.
KW  - Aging
KW  - Personality & emotions
KW  - Perception
KW  - Leisure
KW  - Attitude (Psychology)
KW  - Personality
N1  - Accession Number: 18812152; Authors: Birren, James F. 1; Jerome, Edward A. 1; Chown, Sheila M. 2; Affiliations:  1: National Institute of Mental Health, Bethesda, Maryland;  2: Bedford College, London, England; Subject: Aging; Subject: Personality & emotions; Subject: Perception; Subject: Leisure; Subject: Attitude (Psychology); Subject: Personality; Number of Pages: 13p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
ID  - 2006-06018-017
AN  - 2006-06018-017
AU  - Mishkin, Mortimer
T1  - Blind Spots in Visual Theory.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1961/12//
VL  - 6
IS  - 12
SP  - 446
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06018-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Mishkin, Mortimer; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Blind; Brain; Visual Field; Wounds. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10). Reviewed Item: Teuber, Hans-Lukas; Battersby, William S.; Bender, Morris B. Visual Field Defects after Penetrating Missile Wounds of the Brain=Cambridge, Mass.: Harvard University Press, for the Commonwealth Fund, 1960. Pp. xii + 143. $4.75; 1960. Page Count: 2. Issue Publication Date: Dec, 1961. 
AB  - Reviews the book, Visual Field Defects after Penetrating Missile Wounds of the Brain by Hans-Lukas Teuber, William S. Battersby, and Morris B. Bender (see record [rid]1960-35059-000[/rid]). The presentation, 'half text, half pictures,' moves steadily along from the least to the most questionable aspects of the localizationist doctrine. The one offered by Teuber, Battersby, and Bender is not designed to please localizationists. The authors suggest that the smaller defect for the contralateral eye is due to the low vulnerability of its large crossed projection. There is ample evidence showing that severe visual deficits, apparently unrelated to particular retinal loci, may be produced by nonstriate lesions in animals, and the probability is high that any missile wound in man which damages the primary visual system would damage these secondary visual areas as well. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - visual theory
KW  - blind spots
KW  - visual field defects
KW  - missile wounds
KW  - brain
KW  - 1961
KW  - Blind
KW  - Brain
KW  - Visual Field
KW  - Wounds
KW  - 1961
U2  - Teuber, Hans-Lukas; Battersby, William S.; Bender, Morris B. (1960); Visual Field Defects after Penetrating Missile Wounds of the Brain; Cambridge, Mass.: Harvard University Press, for the Commonwealth Fund, 1960. Pp. xii + 143. $4.75
DO  - 10.1037/006497
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06018-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-001
AN  - 2008-13023-001
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Introduction.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 1
EP  - 19
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-001. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Human Development; Introspection; Longitudinal Studies; Personality Development; Psychotherapy. Minor Descriptor: Interdisciplinary Treatment Approach; Life Experiences. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 19. 
AB  - Many of the behaviors that characterize childhood have transient lives and are either replaced or dropped long before maturity. Egocentric speech, faulty articulation, and fear of the dark are each associated with specific developmental periods, and we are not surprised when they vanish from the behavioral scene. There has always been, however, an explicit and rather dogmatic conviction that selected adult motives, attitudes, and behaviors begin their growth during the first 10 years of life. Once established during the childhood years, these responses are likely to remain permanent aspects of the individual's behavioral repertoire. Retrospective impressions of childhood gathered from psychotherapy sessions, anecdotal reports, and private introspections support this belief, but more substantial evidence has been difficult to obtain. Only systematic longitudinal observations can discover those behaviors that are marked for future use and those that will be lost along the way. This book summarizes an investigation of the personality development of 89 white children (45 females and 44 males) from the Fels Research Institute's longitudinal population. These children, with their parents, have been participants in a longitudinal study of their psychological development from birth through early adulthood. The initiation of this project was coincident with the birth of the Institute and its multidisciplinary study of human development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - longitudinal observations
KW  - personality development
KW  - retrospective impressions
KW  - human development
KW  - psychotherapy sessions
KW  - introspections
KW  - multidisciplinary study
KW  - 1962
KW  - Human Development
KW  - Introspection
KW  - Longitudinal Studies
KW  - Personality Development
KW  - Psychotherapy
KW  - Interdisciplinary Treatment Approach
KW  - Life Experiences
KW  - 1962
DO  - 10.1037/13129-001
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-002
AN  - 2008-13023-002
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Methods of assessment.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 20
EP  - 48
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-002. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Data Collection; Human Development; Longitudinal Studies; Measurement; Methodology. Minor Descriptor: Behavior; Developmental Age Groups; Intelligence Measures; Interviews; Narratives; Observation Methods; Projective Personality Measures; Rating. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Modified Rorschach; Murray (1943) Thematic Apperception Test; Shneidman Make-A-Picture-Story Test (1949); French Insight Test (French 1955; French 1956); Tachistoscopic recognition task; Hanfmann-Kasanin Concept Formation test; Parent Behavior Rating Scale; Child Behavior Rating Scale DOI: 10.1037/t14094-000; Wechsler-Bellevue Intelligence Scale--Form I DOI: 10.1037/t06871-000. Methodology: Empirical Study; Longitudinal Study. Page Count: 29. 
AB  - This chapter describes the methods and sources of data associated with the longitudinal and adult assessments. The longitudinal program will be considered first. The longitudinal material was collected during the years 1929 to 1954. The first few years of data collection were unsystematic, but by 1933 a fairly comprehensive program had taken form, and the program that was established in the 1930's has remained the basic model for data collection up to the present time. The longitudinal data that were used to make the childhood ratings included two major classes of information: (1) narrative reports and ratings of behavior observations and (2) interview protocols and interview summaries. The intelligence and projective test protocols were analyzed independently and did not enter into these ratings. All of these protocols were gathered according to the schedule outlined in Table 3 of Chapter One. The intelligence and personality tests were administered through the use of procedures recommended in their respective manuals. The narrative reports and interview summaries were necessarily subjective and influenced by several uncontrolled factors. Since these reports were the basis of the behavioral ratings covering the first 14 years of life, a description of this material should provide the reader with a base on which to judge the results. The observations were based on visits to the home, visits to the public school, and the child's behavior in the Fels Nursery School and Day Camp. The interview summaries were based on discussions with the child, mother, and the child's teacher. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - longitudinal data
KW  - assessment
KW  - data collection
KW  - intelligence test protocols
KW  - projective tests
KW  - narrative reports
KW  - interview summaries
KW  - behavioral ratings
KW  - home visits
KW  - observations
KW  - interviews
KW  - 1962
KW  - Data Collection
KW  - Human Development
KW  - Longitudinal Studies
KW  - Measurement
KW  - Methodology
KW  - Behavior
KW  - Developmental Age Groups
KW  - Intelligence Measures
KW  - Interviews
KW  - Narratives
KW  - Observation Methods
KW  - Projective Personality Measures
KW  - Rating
KW  - 1962
DO  - 10.1037/13129-002
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-003
AN  - 2008-13023-003
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - The stability of behavior: I. Passivity and dependency.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 49
EP  - 84
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-003. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Dependency (Personality); Human Development; Longitudinal Studies; Measurement; Passiveness. Minor Descriptor: Biology; Data Collection; Predisposition. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 36. 
AB  - The next four chapters describe the pattern of developmental continuity for a group of behaviors that were assessed during both childhood and adulthood. The areas are passivity, dependency, aggression, competitiveness, achievement, recognition, heterosexuality, sex-role identification, social interaction, fear of physical harm, nurturance, compulsivity, and hyperkinesis. This chapter focuses on passive and dependent behavior. Although the data from the present study and those of other investigations must be regarded as highly tentative, they suggest two hypotheses that merit attention: (1) a predisposition to passivity is a function, in part, of biological variables and (2) the foundation for extreme degrees of passivity, or its derivatives, in late childhood, adolescence and adulthood are established during the first six years of life. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - developmental continuity
KW  - childhood behaviors
KW  - assessment
KW  - passivity
KW  - dependency
KW  - human development
KW  - predisposition
KW  - biological variables
KW  - 1962
KW  - Dependency (Personality)
KW  - Human Development
KW  - Longitudinal Studies
KW  - Measurement
KW  - Passiveness
KW  - Biology
KW  - Data Collection
KW  - Predisposition
KW  - 1962
DO  - 10.1037/13129-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-004
AN  - 2008-13023-004
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - The stability of behavior: II. Aggression.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 85
EP  - 119
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-004. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Aggressive Behavior; Childhood Development; Conflict; Developmental Age Groups; Emotional Development. Minor Descriptor: Anger; Emotional Immaturity; Emotions; Family Relations; Human Sex Differences; Injuries; Peer Relations; Rewards; Socialization. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 35. 
AB  - Aggression is a second behavior system that begins its growth during the first five years. Traditionally a response was labeled aggressive if the goal of the behavior was assumed to be psychological or physical injury to a person or person surrogate. We have adhered to this definition. As with dependency, the display of aggressive acts is a regular concomitant of development. The slapping or pushing of an age mate, the destruction of a sibling's new fort, and the stinging verbal attack are regularly observed in the behavior of many children. Aggression, like dependency, is subject to socialization pressures, for the child does not have complete license to unleash his anger when he chooses. In addition, as with dependency, the occurrence of overt aggression is a function of both the threshold for motive arousal and the intensity of anxiety associated with direct expression of this behavior. In contrast to dependency, however, the potential for conflict over aggression is greater for females than for males. The pattern of social rewards and traditional sex-role standards act in concert to discourage the direct expression of aggression in girls and women. It might be anticipated, therefore, that aspects of aggression would be more stable for males than for females. This is precisely what occurred, for overt aggression to mother and frequent tantrums during childhood predicted adult aggressivity for men but not for women. This chapter contains a detailed description of the pattern of stability for different aggressive behaviors. The format follows that of the previous chapter. A cluster of seven aggressive variables was rated for part or all of the four childhood periods, and abridged definitions of these variables follow. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aggression
KW  - aggressive response
KW  - injury as goal
KW  - attacks
KW  - injurious behavior
KW  - development
KW  - children's behavior
KW  - males
KW  - females
KW  - stability pattern
KW  - aggressive variables
KW  - 1962
KW  - Aggressive Behavior
KW  - Childhood Development
KW  - Conflict
KW  - Developmental Age Groups
KW  - Emotional Development
KW  - Anger
KW  - Emotional Immaturity
KW  - Emotions
KW  - Family Relations
KW  - Human Sex Differences
KW  - Injuries
KW  - Peer Relations
KW  - Rewards
KW  - Socialization
KW  - 1962
DO  - 10.1037/13129-004
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-005
AN  - 2008-13023-005
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Stability of behavior: III. Achievement and recognition.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 120
EP  - 155
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-005. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Ability Level; Achievement; Competence; Self-Concept; Social Approval. Minor Descriptor: Expectations; Goals; Human Sex Differences; Praise; Responses; Rewards; Social Acceptance. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 36. 
AB  - Achievement and recognition behaviors are socially valued responses for both boys and girls. It might be anticipated that the stability of achievement and recognition behavior would be generally high for both males and females, in contrast to the pattern found for the previous two response clusters. This expectation was verified in the data to be presented. Achievement and recognition are considered together because the overt behaviors that gratify these motives overlap to a large degree. Achievement is defined as behavior aimed at satisfaction of an internal standard of excellence. The goal of achievement behavior is self-approval for performing tasks at a level of competence that an individual had previously established as satisfying. In recognition behavior, the goal is some positive reaction from other people--a social acknowledgment of the individual's skills. For the present sample, the areas of competence that were most highly prized were intellectual, athletic, mechanical, and artistic abilities. Although competence in these areas brought feelings of self-satisfaction, acquisition of these skills also resulted in social recognition. Family, peers, and teachers awarded praise and prizes for academic, athletic, or artistic achievements. Hence it is extremely difficult to differentiate achievement and recognition motives. Involvement in school work or long hours of baseball practice can indicate strong achievement or recognition motives, or both. The data reveal a high, positive correlation between these two variables. This could mean either that our methods were not sufficiently sensitive to separate these two motives or that it is impossible to measure the desire to improve at a skill, independent of the person's desire for social recognition for this improvement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - achievement behaviors
KW  - social recognition
KW  - goals
KW  - behavioral stability
KW  - self approval
KW  - response clusters
KW  - internal standard of excellence
KW  - positive reaction
KW  - social acknowledgment
KW  - competence
KW  - 1962
KW  - Ability Level
KW  - Achievement
KW  - Competence
KW  - Self-Concept
KW  - Social Approval
KW  - Expectations
KW  - Goals
KW  - Human Sex Differences
KW  - Praise
KW  - Responses
KW  - Rewards
KW  - Social Acceptance
KW  - 1962
DO  - 10.1037/13129-005
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-006
AN  - 2008-13023-006
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - The stability of behavior: IV. Sexuality, social interaction, and selected behaviors.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 156
EP  - 203
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-006. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Heterosexuality; Human Development; Rating; Sex Role Attitudes; Social Interaction. Minor Descriptor: Age Differences; Anxiety; Compulsions; Developmental Age Groups; Fear; Hyperkinesis; Introspection; Longitudinal Studies; Sexuality. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 48. 
AB  - This chapter will consider the stability of heterosexual behavior, traditional sex-role interests, social-interaction anxiety, compulsivity, nurturance, fear of bodily harm, hyperkinesis, and introspectiveness. Some of the variables were only rated for one or two of the longitudinal periods; others for all four age periods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - compulsivity
KW  - stability ratings
KW  - heterosexual behavior
KW  - sex-role interests
KW  - social-interaction
KW  - anxiety
KW  - nurturance
KW  - fear of bodily harm
KW  - introspectiveness
KW  - longitudinal periods
KW  - age periods
KW  - 1962
KW  - Heterosexuality
KW  - Human Development
KW  - Rating
KW  - Sex Role Attitudes
KW  - Social Interaction
KW  - Age Differences
KW  - Anxiety
KW  - Compulsions
KW  - Developmental Age Groups
KW  - Fear
KW  - Hyperkinesis
KW  - Introspection
KW  - Longitudinal Studies
KW  - Sexuality
KW  - 1962
DO  - 10.1037/13129-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-007
AN  - 2008-13023-007
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Maternal practices and the child's behavior.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 204
EP  - 228
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-007. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Childhood Development; Childrearing Practices; Mother Child Relations; Mothers. Minor Descriptor: Criticism; Dependency (Personality); Hostility; Passiveness. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 25. 
AB  - The acquisition and continued practice of a given response are determined by a variety of familial and extra-familial experiences. The nature of the longitudinal data and the existing theoretical climate directed our attention to the influence of one class of antecedent events on the child's developing personality: maternal treatment of the child. Theory and research have acknowledged the profound importance of the mother as a determinant of the child's behavior. As part of the Fels program, observations and interviews with the mothers of our children occurred during the first 12 to 14 years. The sources of these data were described in Chapter Two and consisted primarily of home visits and interviews. From these protocols, four types of maternal practices were evaluated: (a) maternal protection, (b) maternal restrictiveness, (c) maternal hostility and criticism, and (d) maternal acceleration of the child's developmental progress. These variables were defined and rated on a seven-point scale. Despite some suggestive trends, the four maternal behaviors were not highly predictive of adult dependency, especially for men, and were poorer predictors of adult passive or dependent behavior than the child's own behavior during age 6 to 10 or 10 to 14. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - maternal treatment
KW  - children
KW  - child behavior
KW  - mothers
KW  - maternal protection
KW  - restrictiveness
KW  - hostility
KW  - criticism
KW  - interviews
KW  - developmental progress
KW  - dependency
KW  - 1962
KW  - Childhood Development
KW  - Childrearing Practices
KW  - Mother Child Relations
KW  - Mothers
KW  - Criticism
KW  - Dependency (Personality)
KW  - Hostility
KW  - Passiveness
KW  - 1962
DO  - 10.1037/13129-007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-008
AN  - 2008-13023-008
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Sources of conflict and anxiety.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 229
EP  - 265
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-008. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Anxiety; Conflict; Measurement; Tachistoscopic Presentation. Minor Descriptor: Test Validity. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 37. 
AB  - We turned to two popular and objective methods of assessing anxiety and conflict. In the tachistoscopic situation, distortion or delayed recognition of conflictful scenes was presumed to be a consequent of anxiety in the area illustrated. It was assumed that if a specific content were anxiety arousing, ideational representations of this content would be more likely to be repressed and, therefore, less readily available for a correct perceptual hypothesis. That is, the strength of the perceptual hypothesis, 'That is a man choking a man,' should be weaker for adults highly conflicted over aggression than for those with low conflict. The order of recall of these scenes (90 minutes later) was used as a supplementary index of conflict (i.e., decreased availability of the anxiety-arousing ideas). A second potential index of conflict-produced anxiety was a change in either heart rate or palmar conductance in response to an anxiety-arousing communication. Since anxiety is a state of affective arousal, it seems reasonable to conclude that the intensity of anxiety elicited by a stimulus should be reflected in a proportional amount of discharge in autonomic target organs. Five sources of anxiety were studied: conflict over dependency, aggression, and sexual behavior, as well as anxiety over bodily harm and intellectual competence. The tachistoscopic task sampled the areas of dependency, aggression, sexuality, and bodily harm; the autonomic battery sampled anxiety over aggression, sexuality, bodily harm, and intellectual competence. The assumption that delayed recognition of conflictful scenes or autonomic discharge to conflictful communications reflects anxiety is of questionable validity. Many investigators are attempting to prove or disprove these hypotheses. The data to be reported, therefore, bear directly on this important methodological problem: the validity of tachistoscopic perception or autonomic discharge as indexes of anxiety associated with behavior and goal states that are regarded as conflictful in this society. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - anxiety
KW  - conflict scenes
KW  - measurement
KW  - tachistoscopic perception
KW  - autonomic discharge
KW  - 1962
KW  - Anxiety
KW  - Conflict
KW  - Measurement
KW  - Tachistoscopic Presentation
KW  - Test Validity
KW  - 1962
DO  - 10.1037/13129-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2008-13023-009
AN  - 2008-13023-009
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Summary and conclusions.
T2  - Birth to maturity: A study in psychological development.
Y1  - 1962///
SP  - 266
EP  - 286
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-009. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Behavior; Dependency (Personality); Human Development; Passiveness; Sex Role Attitudes. Minor Descriptor: Anger; Anxiety; Emotional Adjustment; Longitudinal Studies; Personality Development; Sex Roles; Stress. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 21. 
AB  - In this summary chapter, the authors present five conclusions that are relevant for developmental theory or for current methodological issues. The following topics are discussed: (1) differential stability of behavior as a function of sex typing; (2) sex differences in patterns of relationships; (3) the significance of early passivity; (4) the sleeper effect; and (5) conceptual style, autonomic reactivity and the measurement of conflict. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - childhood behaviors
KW  - childhood development
KW  - sex differences
KW  - sex typing
KW  - passivity
KW  - conceptual style
KW  - autonomic reactivity
KW  - measurement
KW  - conflict
KW  - dependency
KW  - 1962
KW  - Behavior
KW  - Dependency (Personality)
KW  - Human Development
KW  - Passiveness
KW  - Sex Role Attitudes
KW  - Anger
KW  - Anxiety
KW  - Emotional Adjustment
KW  - Longitudinal Studies
KW  - Personality Development
KW  - Sex Roles
KW  - Stress
KW  - 1962
DO  - 10.1037/13129-009
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2004-19281-013
AN  - 2004-19281-013
AU  - Shakow, David
ED  - Strupp, Hans H.
ED  - Luborsky, Lester
ED  - Strupp, Hans H., (Ed)
ED  - Luborsky, Lester, (Ed)
T1  - Discussion of Papers Relating to Definition of Variables.
T2  - Research in psychotherapy.
Y1  - 1962///
SP  - 237
EP  - 241
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2004-19281-013. Partial author list: First Author & Affiliation: Shakow, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20041025. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Comment/Reply. Language: English. Conference Information: Second Conference on Research in Psychotherapy, May, 1961, Chapel Hill, NC, US. Major Descriptor: Experimentation; Psychotherapy. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 5. 
AB  - Comments on papers by J. M. Butler et al (see record [rid]2004-19281-010[/rid]), R. S. Siegal and I. C. Rosen 200419281-011), and H. L. Lennard 200419281-012) about research problems relating to the definition of variables in psychotherapy. In relation to the Butler et al paper, D. Shakow raises several questions about the place and limits of the naturalistic approach in the study of the psychotherapy situation. In the case of Lennard, Shakow considers particularly the problem of deutero-learning and its relationship to the kinds of learning which take place in psychotherapy. And with respect to Siegal and Rosen's paper, Shakow examines further the use of inference in the psychodiagnostic situation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychotherapy
KW  - research problems
KW  - definition of variables
KW  - 1962
KW  - Experimentation
KW  - Psychotherapy
KW  - 1962
DO  - 10.1037/10591-013
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19281-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2004-19281-014
AN  - 2004-19281-014
AU  - Parloff, Morris B.
ED  - Strupp, Hans H.
ED  - Luborsky, Lester
ED  - Strupp, Hans H., (Ed)
ED  - Luborsky, Lester, (Ed)
T1  - Summary Report: Therapist's Contribution (A).
T2  - Research in psychotherapy.
Y1  - 1962///
SP  - 256
EP  - 258
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2004-19281-014. Partial author list: First Author & Affiliation: Parloff, Morris B.; Section on Personality, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20041025. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Conference Information: Second Conference on Research in Psychotherapy, May, 1961, Chapel Hill, NC, US. Major Descriptor: Experimentation; Psychotherapeutic Processes; Psychotherapists; Psychotherapy. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - Presents a summary report of a panel discussion on research problems relating to the psychotherapist's contribution to the treatment process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychotherapist's contribution to treatment process
KW  - research problems
KW  - 1962
KW  - Experimentation
KW  - Psychotherapeutic Processes
KW  - Psychotherapists
KW  - Psychotherapy
KW  - 1962
DO  - 10.1037/10591-014
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19281-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - BOOK
ID  - 2008-13023-000
AN  - 2008-13023-000
AU  - Kagan, Jerome
AU  - Moss, Howard A.
T1  - Birth to maturity: A study in psychological development.
Y1  - 1962///
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
N1  - Accession Number: 2008-13023-000. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Developmental Age Groups; Human Development; Longitudinal Studies; Measurement; Personality Measures. Minor Descriptor: Age Differences; Psychoanalysis; Psychoanalytic Theory; Testing. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 381. 
AB  - This book is a summary of a comprehensive assessment of a group of young adults who have been members of the Fels Research Institute's longitudinal population since their birth. The potential contributions of this longitudinal investigation fall into four categories. The findings of this study point to islands of continuity amidst the changing response patterns of the growing child and suggest that some popular hypotheses about development need revision. This investigation uncovered several new and provocative ideas about developmental sequences that are not emphasized by current theorists and that deserve careful empirical attention. Finally, we attempted to test the validity of some contemporary personality assessment techniques by studying the relations between the test protocols produced by our subjects and the rich and extensive behavioral information available on each of them. There is one set of issues that this book does not presume to evaluate. The gathering of the early longitudinal data was not guided by a consistent theoretical orientation, and it is impossible, therefore, to comment on the validity of psychoanalytic or behavioral theory as they refer to cause-effect sequences in development. Correlatively, this book does not contain any elaborate theoretical integration of psychological development. We would have liked to assume this responsibility but the data prohibited such an ambitious undertaking. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - comprehensive assessment
KW  - young adults
KW  - development
KW  - longitudinal population
KW  - developmental sequences
KW  - personality assessment techniques
KW  - test protocols
KW  - behavioral information
KW  - psychoanalytic theory
KW  - 1962
KW  - Developmental Age Groups
KW  - Human Development
KW  - Longitudinal Studies
KW  - Measurement
KW  - Personality Measures
KW  - Age Differences
KW  - Psychoanalysis
KW  - Psychoanalytic Theory
KW  - Testing
KW  - 1962
DO  - 10.1037/13129-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Pearlin, Leonard I.
T1  - ALIENATION FROM WORK: A STUDY OF NURSING PERSONNEL.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1962/06//
VL  - 27
IS  - 3
M3  - Article
SP  - 314
EP  - 326
SN  - 00031224
AB  - Alienation, defined as subjectively experienced powerlessness to control one's own work activities, is examined among the nursing force of a large mental hospital. It is found that alienation is intensified where authority relations are such as to limit the reciprocal influence of subordinates. This is reflected in situations where there is great positional disparity between superordinates and their subjects, where authority is exercised in a peremptory fashion and where authority figures are physically inaccessible. Career experiences within the hospital opportunity structure are also related to alienation; limited achievement and dissatisfaction with extrinsic work rewards are alienative conditions. Finally, personnel working in isolation and without outside social ties to fellow workers are more subject to intense alienation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOSPITAL personnel
KW  - MEDICAL care
KW  - PSYCHIATRIC hospitals
KW  - EMPLOYEES
KW  - AUTHORITY
KW  - ALIENATION (Social psychology)
N1  - Accession Number: 12766591; Pearlin, Leonard I. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Jun62, Vol. 27 Issue 3, p314; Thesaurus Term: HOSPITAL personnel; Thesaurus Term: MEDICAL care; Thesaurus Term: PSYCHIATRIC hospitals; Thesaurus Term: EMPLOYEES; Thesaurus Term: AUTHORITY; Subject Term: ALIENATION (Social psychology); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
T1  - SELF-ESTEEM AND CONCERN WITH PUBLIC AFFAIRS.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1962///Summer62
VL  - 26
IS  - 2
M3  - Article
SP  - 201
EP  - 211
SN  - 0033362X
AB  - The problem of self-esteem is a very different one when seen from the viewpoint of the individual than when considered from the perspective of society. From the viewpoint of the individual, fundamental self-hatred is a tragedy of no mean proportions, compounded of depression, tension, and anxiety, and in various ways warping the lives of those afflicted with it. From the viewpoint of society, it has clear implications for the operation of a democratic system of society. For if democracy provides a mechanism by which citizens can have their wills translated into political policy, then it becomes farcical to speak of democracy if it is broadly based upon an ignorant, uninterested, and uninfluential electorate. Hence, the family and other social conditions which operate to destroy the child's sense of worth are at the same time undermining the personality prerequisites of a democratic society. The main reassurance lies in the fact that, at least according to the data, so many more adolescents appear to be characterized by a fundamental feeling of self-acceptance than seem to be afflicted with feelings of self-rejection.
KW  - Self-esteem
KW  - Political science
KW  - Self-acceptance
KW  - Anxiety
KW  - Emotions (Psychology)
KW  - Democracy
KW  - Social history
N1  - Accession Number: 11956487; Rosenberg, Morris 1; Affiliations: 1: Social Science Analyst, Laboratory of Socio-environmental Studies, National Institute of Mental Health.; Issue Info: Summer62, Vol. 26 Issue 2, p201; Thesaurus Term: Self-esteem; Thesaurus Term: Political science; Subject Term: Self-acceptance; Subject Term: Anxiety; Subject Term: Emotions (Psychology); Subject Term: Democracy; Subject Term: Social history; Number of Pages: 11p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11956487&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
T1  - AN OTHER-DIRECTED FANTASY IN A PUERTO RICAN.
AU  - Field, P. B.
AU  - Maldonado-Sierra, E. D.
AU  - Wallace, S. E.
AU  - Bodarky, C. J.
AU  - Coelho, G. V.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1962/10//
VL  - 58
IS  - 1
SP  - 43
EP  - 60
SN  - 00224545
N1  - Accession Number: 16487527; Author: Field, P. B.: 1 Author: Maldonado-Sierra, E. D.: 1 Author: Wallace, S. E.: 1 Author: Bodarky, C. J.: 1 Author: Coelho, G. V.: 1 ; Author Affiliation: 1 Puerto Rico Institute of Psychiatry and National Institute of Mental Health.; No. of Pages: 18; Language: English; Publication Type: Article; Update Code: 20050323
N2  - A TAT story in which the hero decided to adjust himself to a peer group's wishes is the starting point of a case study of the personal relationships of a Puerto Rican college student. The student is one of 20 studied in an attempt to extend cross-culturally a research program on students who showed superiority in the social, academic, and extracurricular spheres. We related our analysis of this student to various cultural themes in Puerto Rico--including the familism, the exaggerated masculine role prescribed for males, and the preferential treatment given the oldest son in the family. While we emphasized the multiple determination of this student's other-directed peer-group dependency, we concluded that one major determining factor in his dependency is an unrewarding, distant relationship to his family, leading to a search for compensating personal relationships with other social groups. This student's unsatisfying formal, hierarchical, and impersonal family relationships lead him to seek instead the informal, personal, loosely-organized relationships of a peer group. He tries to achieve success through dependency, conformity, obedience, and conciliation rather than through independent self-assertion; previous authors have reported that many Puerto Ricans tend to share some of these traits. ABSTRACT FROM AUTHOR
KW  - *COLLEGE students
KW  - *GROUP decision making
KW  - AGE groups
KW  - INTERPERSONAL relations
KW  - SOCIAL groups
KW  - PUERTO Rico
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=16487527&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
AU  - Pearlin, Leonard I.
T1  - Power-Orientations in the Mental Hospital.
JO  - Human Relations
JF  - Human Relations
Y1  - 1962/11//
VL  - 15
IS  - 4
M3  - Article
SP  - 335
EP  - 349
SN  - 00187267
AB  - The article provides information on the research conducted to determine if mental hospital nurses exercise their power when face with difficult situation. According to the author, the aim of the study is to evaluate how mental hospital staff tend to implement to control the situation and to examine the criteria that they use when a situation require. He adds that exercise and implementation of power is required especially in the area of life involving human interaction and association to control, motivate and influence the behavior of patients and projects authoritative personality. Questionnaires, intensive interviews were used to collect data and personal experience accounts of the respondents were presented.
KW  - MENTAL health personnel
KW  - MEDICAL care
KW  - PSYCHIATRIC hospitals
KW  - MENTAL health facilities
KW  - QUESTIONNAIRES
KW  - RESEARCH
KW  - PSYCHIATRIC nurses
KW  - PATIENTS
KW  - MENTALLY ill -- Care
N1  - Accession Number: 24585976; Rosenberg, Morris 1; Pearlin, Leonard I.; Affiliations: 1: Social Science Analyst, Laboratory of Social-Environmental Studies, National Institute of Mental Health; Issue Info: Nov62, Vol. 15 Issue 4, p335; Thesaurus Term: MENTAL health personnel; Thesaurus Term: MEDICAL care; Thesaurus Term: PSYCHIATRIC hospitals; Thesaurus Term: MENTAL health facilities; Thesaurus Term: QUESTIONNAIRES; Thesaurus Term: RESEARCH; Subject Term: PSYCHIATRIC nurses; Subject Term: PATIENTS; Subject Term: MENTALLY ill -- Care; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621112 Offices of Physicians, Mental Health Specialists; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; Number of Pages: 15p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-06029-015
AN  - 2006-06029-015
AU  - Coelho, George V.
T1  - un-American Social Psychology.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1962/11//
VL  - 7
IS  - 11
SP  - 420
EP  - 421
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06029-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Coelho, George V.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Culture (Anthropological); Mind; Social Psychology; Society. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Akolkar, V. V. Social Psychology: A Study of Mind in Society=London: Asia Publishing House (U. S. Distr. Taplinger Publishing Co., Inc.) 4th edition, 1960. Pp. 307. $4.50; 1960. Page Count: 2. Issue Publication Date: Nov, 1962. 
AB  - Reviews the book, Social Psychology: A Study of Mind in Society by V. V. Akolkar (1960). Persistent issues in social psychology usually include group mind theories, the nature of social learning, the development of social motives, the articulation of individual personality with social systems, and the influence of culture patterns on social perception and interaction. Professor Akolkar deals lucidly with these broad theoretical issues in the first half of his book, using scholarly detail in historical perspective that is often lost to the present-day student. Neglectful of significant modern sources, Professor Akolkar nevertheless shows sound judgment and imagination in examining older authorities. He criticizes McDougall--whose Social Psychology (1908) was the first book to be published with that title--for his theories of instinct and national character. The chapter on Personality nicely divides the book into two major sections. Professor Akolkar suggests that the evolution of religious consciousness, like that of moral consciousness, is marked by an increasing refinement in man's view of, and relationship with the Unseen. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - American social psychology
KW  - mind
KW  - society
KW  - individual personality
KW  - culture patterns
KW  - 1962
KW  - Culture (Anthropological)
KW  - Mind
KW  - Social Psychology
KW  - Society
KW  - 1962
U2  - Akolkar, V. V. (1960); Social Psychology: A Study of Mind in Society; London: Asia Publishing House (U. S. Distr. Taplinger Publishing Co., Inc.) 4th edition, 1960. Pp. 307. $4.50
DO  - 10.1037/006775
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06029-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - D'Arnonlo, William V.
AU  - Ehrlich, Howard J.
AU  - Erickson, Eugene C.
T1  - FURTHER NOTES ON THE STUDY OF COMMUNITY POWER.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1962/12//
VL  - 27
IS  - 6
M3  - Article
SP  - 848
EP  - 854
SN  - 00031224
AB  - The exchanges with Raymond E. Wolfinger and Nelson W. Polsby perform, perhaps, a necessary function in keeping everyone alert to the problems and ambiguities of the studies. This is, at least, better than having such difficulties "resolved" by passive consent and "tradition." It is regretted that, in this exchange, the editorial deadline did not permit a more detailed exploration of the related and clearly important unresolved issues of community power research and theory. The phenomenon of continual innovation in methodology, coupled with the fact that most research known today employs elements of both "reputational" and "decision-making" techniques, serves only to heighten the concern with methodology. While the deficiencies of reputational techniques have received considerable attention and currency, the issues or decision-making approach has received little in the way of critical scrutiny. Certainly, such matters as defining community issues, the salience of issues, and the sampling of issues have received relatively little attention.
KW  - DECISION making
KW  - RESEARCH
KW  - COMMUNITY power
KW  - METHODOLOGY
KW  - WOLFINGER, Raymond E., 1931-2015
KW  - POLSBY, Nelson W.
N1  - Accession Number: 12788907; D'Arnonlo, William V. 1; Ehrlich, Howard J. 2; Erickson, Eugene C. 3; Affiliations: 1: University of Notre Dame; 2: National institute of Mental Health; 3: Washington State University; Issue Info: Dec62, Vol. 27 Issue 6, p848; Thesaurus Term: DECISION making; Thesaurus Term: RESEARCH; Subject Term: COMMUNITY power; Subject Term: METHODOLOGY; People: WOLFINGER, Raymond E., 1931-2015; People: POLSBY, Nelson W.; Number of Pages: 7p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12788907&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - Gen
ID  - 9999-14266-000
AN  - 9999-14266-000
AU  - Katz, Martin M.
AU  - Lyerly, Samuel B.
T1  - Katz Adjustment Scale--Form R2
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1963///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No
N1  - Accession Number: 9999-14266-000. Partial author list: First Author & Affiliation: Katz, Martin M.; National Institute of Mental Health, Psychopharmacology Service Center, United States. Release Date: 20120910. Language: English. Constructs: Adjustment; Population: Human (10). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Katz Adjustment Scale--Form R2 is to assess adjustment.
AB  - Description: The Katz Adjustment Scale--Form R2 (Katz & Lyerly, 1963) inventory consists of a list of 16 activities which include items describing family and social responsibilities, social activites, self-care, home adjustment, and community activities. The list is a modification of one prepared by Freeman and Simmons (1958). The relative indicates for a given activity whether the patient 'is not doing it,' 'is doing it some,' or 'is doing it regularly.' The items are rated on a three-point scale and summed for a total score. The score is viewed simply as a measure of the level or amount of socially expected activities in which the patient has been involved during the several weeks preceding the relative's report.
KW  - Katz Adjustment Scale--Form R2
KW  - Test Development
KW  - Social Behavior
KW  - Community Readjustment
KW  - Discriminative Validity
KW  - Rationale
KW  - Description
U5  - Katz Adjustment Scale--Form R2 [Test Development]Methods for measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. (AN: 1964-08391-001 from PsycINFO) Katz, Martin M.; Lyerly, Samuel B.; 1963. Source: Psychological Reports. 13(2), Psychological Reports, US; 1963; Administration: Paper Population: Human; Sample: Hospital Patients Readjusting to the Community; Location: United States Keywords: Katz Adjustment Scale--Form R2; Test Development; Social Behavior; Community Readjustment; Discriminative Validity; Rationale; Description; Subjects: Psychosocial Readjustment; Rating Scales; Social Adjustment; Social Behavior; Test Construction; Test Forms; Test Validity;
DO  - 10.1037/t14266-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-14266-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-14270-000
AN  - 9999-14270-000
AU  - Katz, Martin M.
AU  - Lyerly, Samuel B.
T1  - Katz Adjustment Scale--Form R4
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1963///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No
N1  - Accession Number: 9999-14270-000. Partial author list: First Author & Affiliation: Katz, Martin M.; National Institute of Mental Health, Psychopharmacology Service Center, United States. Release Date: 20120910. Language: English. Constructs: Adjustment; Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Katz Adjustment Scale--Form R4 is to objectively assess the adjustment and social behavior of pre-psychotic and ex-hospital patients in the community.
AB  - Description: The Katz Adjustment Scale--Form R4 (Katz & Lyerly, 1963) is an inventory for objectively assessing the adjustment and social behavior of pre-psychotic and ex-hospital patients in the community. The major characteristics of the scales are their reliance on both the patient and a relative in measuring social behavior, the use of a relative as a direct reporter, and the establishment of his reliability in describing patient behavior. The scales have been designed for application to the problems of describing and classifying patients in accordance with their behavior prior to entrance to the hospital and in the community follow-up evaluation and comparison of psychiatric treatments. In a comparison of well- and poorly- adjusted groups of patients, the scales are demonstrated to be highly discriminative and capable of closely approximating expert clinical judgment.
KW  - Factor Analysis
KW  - Katz Adjustment Scale--Form R4
KW  - Psychoticism
KW  - Test Development
KW  - Psychometric Properties
U5  - Katz Adjustment Scale--Form R4 [Test Development]Methods for measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. (AN: 1964-08391-001 from PsycINFO) Katz, Martin M.; Lyerly, Samuel B.; 1963. Source: Psychological Reports. 13(2), Psychological Reports, US; 1963; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Location: United States; Sample: Psychiatric Patients Keywords: Factor Analysis; Katz Adjustment Scale--Form R4; Psychoticism; Test Development; Psychometric Properties; Subjects: Factor Analysis; Psychoticism; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t14270-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-14270-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-04041-000
AN  - 9999-04041-000
AU  - Katz, Martin M.
AU  - Lyerly, Samuel B.
T1  - Katz Adjustment Scales
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1963///
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-04041-000. Acronyms: KAS. Partial author list: First Author & Affiliation: Katz, Martin M.; National Institute of Mental Health, Psychopharmacology Service Center, United States. Release Date: 20130107. Instrument Type: Rating Scale. Test Format: Items in both sets of inventories are rated on 3- and 4-point scales.. Language: English. Constructs: Functional Ability; Classification: Functional Status and Adaptive Behavior (6200). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The Katz Adjustment Scales are designed to assess different aspects of the patient's functioning in the community from two points of view, a close relative's and the patient's.
AB  - Description: The Katz Adjustment Scales (KAS; Katz & Lyerly, 1963) is a set of inventories for objectively assessing the adjustment and social behavior of pre-psychotic and ex-hospital patients in the community. The major characteristics of the scales are their reliance on both the patient and a relative in measuring social behavior, the use of a relative as a direct reporter, and the establishment of his reliability in describing patient behavior. The scales have been designed for application to the problems of describing and classifying patients in accordance with their behavior prior to entrance to the hospital and in the community follow-up evaluation and comparison of psychiatric treatments. The 127-item Form R1 (Relative's Ratings of Patient Symptoms and Social Behavior) was designed to provide a record of the patient's symptomatology and social behavior during a period of several weeks prior to the relative's report. Form R2 (Level of Performance of Socially-Expected Activities) consists of a list of 16 activities which include items describing family and social responsibilities, social activites, self-care, home adjustment, and community activities. Items in Form R3 (Level of Expectations) are identical to those in Form R2; however, the relative is asked to indicate for a given activity whether he had or had not expected the patient to be doing this within a reasonable time following his return to the home. Form RS4 (Level of Free-Time Activities) is modeled after the Activities and Attitudes Scales (Cavan, et al., 1949); the 23 items cover hobbies, social and community activities, and self-improvement activicies. The items in Form R5 (Level of Satisfaction with Free-Time Activities) are identical to those in Form RS4; the relative is asked for a given activity, whether he is satisfied with what the patient is doing in this area, or whether he would like to see him do more or do less of this activity. The 55-item Form S1 (Symptom Discomfort) measures patient discomfort in the symptom area; items were slightly modified from the Johns Hopkins Symptom Distress Checklist described by Parloff et al (1954). Form S2 (Level of Performance of Socially-Expected Activities), Form S9 (Level of Expectations), Form RS4 (Level of Free-Time Activities, and Form SS (Level of Satisfaction with Free-Time Activities are adapted for self-ratings but are otherwise identical to those designed for the relatives (Forms Forms R2, R3, RS4, and R5). In a cross-validation sample, the measures are found to have reasonably high internal consistency and to demonstrate stable relationships with the other measures in the set. (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW  - Katz Adjustment Scales
KW  - Patient Forms
KW  - Relative Forms
KW  - Social Behavior
KW  - Patient Functioning
KW  - Discriminative Validity
KW  - Pre-Psychotic Patients
KW  - Ex-Hospital Patients
KW  - Clinical Adjustment
U5  - Katz Adjustment Scales (KAS) [Test Development]Methods for measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. (AN: 1964-08391-001 from PsycINFO) Katz, Martin M.; Lyerly, Samuel B.; 1963. Source: Psychological Reports. 13(2), Psychological Reports, US; 1963; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Outpatient; Sample: Psychiatric Patients Keywords: Katz Adjustment Scales; Patient Forms; Relative Forms; Social Behavior; Patient Functioning; Discriminative Validity; Pre-Psychotic Patients; Ex-Hospital Patients; Clinical Adjustment; Subjects: Ability Level; Adjustment; Hospitalized Patients; Social Behavior; Test Validity;
DO  - 10.1037/t04041-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-04041-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - CHAP
ID  - 2007-15047-008
AN  - 2007-15047-008
AU  - Stern, Edith M.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - The aging and the aged.
T2  - The encyclopedia of mental health, Vol I.
Y1  - 1963///
SP  - 153
EP  - 178
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15047-008. Partial author list: First Author & Affiliation: Stern, Edith M.; National Institute of Mental Health, US. Release Date: 20071022. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Aging. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Page Count: 26. 
AB  - The topics discussed in this entry include: the definition of aging and the aging process; mental abilities of the aging; sex drives of the aging; emotional problems of the aging; retirement and the decline of health and spirits in the aging; the physical health of the aged today compared to former times; life expectancy of the aged; attitudes toward the aged; rate of suicide in the aging; and mental disorders of the aged and treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aging
KW  - aged
KW  - 1963
KW  - Aging
KW  - 1963
DO  - 10.1037/11558-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15047-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15047-013
AN  - 2007-15047-013
AU  - Kety, Seymour S.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Biological factors in mental illness.
T2  - The encyclopedia of mental health, Vol I.
Y1  - 1963///
SP  - 227
EP  - 234
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15047-013. Partial author list: First Author & Affiliation: Kety, Seymour S.; Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20071022. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Biology; Mental Disorders. Classification: Psychological Disorders (3210). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. 
AB  - The topics discussed in this entry include: enthusiasm regarding the biological basis of mental health; progress in the demonstrating biological bases for some biological illnesses; mental disorders caused by biological factors; biological factors role in major psychoses; biological factors shown in schizophrenia; serotonin's role in schizophrenia and reasons to support biochemical factors in schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - biological factors
KW  - mental disorders
KW  - 1963
KW  - Biology
KW  - Mental Disorders
KW  - 1963
DO  - 10.1037/11558-013
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15047-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15048-033
AN  - 2007-15048-033
AU  - Rosenthal, David
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Heredity and mental health.
T2  - The encyclopedia of mental health, Vol II.
Y1  - 1963///
SP  - 724
EP  - 735
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15048-033. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Genetics; Mental Health. Classification: Psychological & Physical Disorders (3200); Genetics (2510). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12. 
AB  - The topics discussed in this entry include: the history of heredity and mental health; mental disorders that have been studied with respect to whether or not they are inherited; inherited schizophrenia; environmental factors important in causing schizophrenia; and the prospects for achieving a detailed understanding of the relationship between heredity and mental health. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - heredity
KW  - 1963
KW  - Genetics
KW  - Mental Health
KW  - 1963
DO  - 10.1037/11549-033
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15048-033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15050-006
AN  - 2007-15050-006
AU  - Stern, Edith M.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Mental retardation.
T2  - The encyclopedia of mental health, Vol IV.
Y1  - 1963///
SP  - 1180
EP  - 1203
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15050-006. Partial author list: First Author & Affiliation: Stern, Edith M.; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Intellectual Development Disorder. Classification: Developmental Disorders & Autism (3250). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 24. 
AB  - This entry discusses mental retardation. The topics covered include: Who are the mentally retarded; are there different degrees of mental retardation, if so, what are they, and what is their distribution among all the mentally retarded; what is the cause of mental retardation; how many persons in the United States are mentally retarded; how many of the mentally retarded are in institutions; do United States estimates of the prevalence of mental retardation differ from those of other countries; is the incidence of mental retardation in the United States greater in either of the sexes, at certain ages, in any particular national, racial, economic, or religious group,in rural or urban groups; is the number of mentally retarded in the United States increasing or decreasing, why; would euthanasia be preferable to keeping alive the severely retarded who give no evidence that they can ever contribute to the community or get anything out of life personally; what has been the history of society's attitude toward the mentally retarded; is mental retardation curable; is mental retardation preventable; are the mentally retarded identifiable by their appearance; what characteristics are common to the mentally retarded; is the mentally retarded individual aware of his difference, if so, how can he be helped to adjust to such awareness; what are some of the special emotional problems of the mentally retarded; is it possible for the mentally retarded to become mentally ill, if so, are there mental disorders that affect them especially; can psychotherapy be useful for mentally retarded persons; why do some mentally retarded children and adults have odd mannerisms such as repeating movements or words, or grinning or giggling without apparent reason; is mental retardation associated with epilepsy, cerebral palsy; how early can the symptoms of mental retardation be recognized; how and by whom is the diagnosis of mental retardation made; is it possible for the I.Q. of the mentally retarded to change; is it desirable for couples who have had a retarded child to have other children; what effect can a mentally retarded child have on the family; when ought the mentally retarded child to be put into residential care rather than to live at home; is the incidence of delinquency higher among the mentally retarded than among the general population; what are the sexual attributes of the mentally retarded; how prevalent are special classes in the public schools, what is taught in these classes; are the mentally retarded employable; ought the mentally retarded to marry; and what agencies are specifically concerned with mental retardation, do they adequately meet the need. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental retardation
KW  - 1963
KW  - Intellectual Development Disorder
KW  - 1963
DO  - 10.1037/11547-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15050-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15050-030
AN  - 2007-15050-030
AU  - Felix, Robert H.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - The National Institute of Mental Health.
T2  - The encyclopedia of mental health, Vol IV.
Y1  - 1963///
SP  - 1292
EP  - 1305
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15050-030. Partial author list: First Author & Affiliation: Felix, Robert H.; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Government Agencies; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 14. 
AB  - This entry discusses the National Institute of Mental Health. The topics covered include: what is The National Institute of Mental Health (NIMH); why was the NIMH created; how many professionals work at the NIMH; how has the Institute developed its program; what are the Institute's research interests; how is a research grant made; what are the Institute's training programs; how do the community services programs operate; what have been the Institute's past accomplishments; what are the Institute's future goals; and how do the programs of the NIMH fit into the other health activities of the Federal Government. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - National Institute Mental Health
KW  - 1963
KW  - Government Agencies
KW  - Mental Health
KW  - 1963
DO  - 10.1037/11547-030
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15050-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15051-013
AN  - 2007-15051-013
AU  - Shakow, David
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Psychology.
T2  - The encyclopedia of mental health, Vol V.
Y1  - 1963///
SP  - 1618
EP  - 1633
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15051-013. Partial author list: First Author & Affiliation: Shakow, David; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: History of Psychology; Psychologists; Psychology. Classification: General Psychology (2100). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16. 
AB  - This chapter covers psychology. In particular, it discusses the aims of psychology; psychology's general principles; the major phenomena with which psychology deals; how psychology deals with these phenomena; psychology's history; the different schools of thought in psychology; what purpose different formulations and schools serve; is psychology a science; how does a psychologist differ from a psychiatrist; how many psychologists are there in the United States; is the present number adequate; do the number of psychologists differ in other countries; where and for whom do psychologists work; the salary levels; the various functions of the psychologist; the attitudes toward psychologists as therapists; the contributions of psychology as a science and as a profession; How everyday living has changed because of the results of the study of psychology; and the status of psychology and psychologists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychology
KW  - psychologists
KW  - history
KW  - 1963
KW  - History of Psychology
KW  - Psychologists
KW  - Psychology
KW  - 1963
DO  - 10.1037/11559-013
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15051-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15051-015
AN  - 2007-15051-015
AU  - Cole, Jonathan O.
AU  - Cole, Kathleen G.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Psychopharmacology.
T2  - The encyclopedia of mental health, Vol V.
Y1  - 1963///
SP  - 1654
EP  - 1663
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15051-015. Partial author list: First Author & Affiliation: Cole, Jonathan O.; Psychopharmacology Service Center, National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Drug Therapy; Psychopharmacology. Minor Descriptor: Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 10. 
AB  - This chapter covers psychopharmacology. Specifically, it looks at what is psychopharmacology; what kinds of drugs have psychopharmacological effects; major tranquilizers; minor tranquilizers; antidepressants; stimulants; psychotomimetics; if the new drugs will empty our mental hospitals; can the drugs currently used for the treatment of mental illness cure mental illness; how long must an emotionally ill person continue to take drugs; do these drugs have harmful effects if taken for a period of months or years; can these drugs be used to treat children who have emotional disorders; are psychopharmacologic agents used for the treatment of nonpsychiatric conditions; who can prescribe psychopharmacologic agents; do drugs interfere with psychotherapy; will drugs replace psychotherapy; do drugs interfere with driving; do drugs affect the patient's response to alcohol or other nonpsychoactive drugs; is it all right to borrow tranquilizing drugs from friends; can one become addicted to any of these drugs; do these drugs affect all people in the same way; are drugs useful in the treatment of alcoholism; can psychoactive drugs cure mental retardation; are these drugs helpful in psychiatric conditions of later life; does science understand how these drugs act; and will drugs be developed that can really cure mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychopharmacology
KW  - mental illness
KW  - 1963
KW  - Drug Therapy
KW  - Psychopharmacology
KW  - Mental Disorders
KW  - 1963
DO  - 10.1037/11559-015
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15051-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15053-006
AN  - 2007-15053-006
AU  - Kohn, Melvin L.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Social psychology.
T2  - The encyclopedia of mental health, Vol VI.
Y1  - 1963///
SP  - 1925
EP  - 1932
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15053-006. Partial author list: First Author & Affiliation: Kohn, Melvin L.; Laboratory of Socio-environmental Studies, National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Mental Health; Social Psychology. Minor Descriptor: Mental Disorders; Social Psychologists. Classification: Social Psychology (3000). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. 
AB  - This chapter covers social psychology. In particular, it discusses the origins of social psychology; if social psychology has a characteristic way of explaining behavior; if there is a basic conflict between social psychology and psychoanalysis; some of the principal problems with which social psychologists are concerned; methods social psychologists use in their research; the sample survey; the ways that social psychology is relevant to mental illness; if there is any evidence that the individual's position in society has an appreciable effect on the likelihood of his becoming mentally ill; the ways in which social psychology is relevant to mental health; and what might be predicted about the methods and scope of social psychology in the near future. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social psychology
KW  - mental health
KW  - mental illness
KW  - 1963
KW  - Mental Health
KW  - Social Psychology
KW  - Mental Disorders
KW  - Social Psychologists
KW  - 1963
DO  - 10.1037/11560-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15053-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-15053-012
AN  - 2007-15053-012
AU  - Korchin, Sheldon J.
ED  - Deutsch, Albert
ED  - Fishman, Helen
ED  - Deutsch, Albert, (Ed)
ED  - Fishman, Helen, (Ed)
T1  - Stress.
T2  - The encyclopedia of mental health, Vol VI.
Y1  - 1963///
SP  - 1975
EP  - 1982
CY  - New York, NY, US
PB  - Franklin Watts
N1  - Accession Number: 2007-15053-012. Partial author list: First Author & Affiliation: Korchin, Sheldon J.; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Stress. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. 
AB  - This chapter covers stress. In particular, it looks at the difference between physical and psychological stress; some kinds of psychological stress; the major psychological reactions to stress; defense mechanisms; how stress and anxiety are related; is a certain amount of stress desirable; is minimal stimulation stressful; the relation between stress and bodily functioning; how does psychological functioning change under stress; do people differ in their stress resistance; is extreme stress a major factor in mental disease; and the stresses of present-day society. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological stress
KW  - physical stress
KW  - 1963
KW  - Stress
KW  - 1963
DO  - 10.1037/11560-012
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15053-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-001
AN  - 2007-02259-001
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Introduction.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 1
EP  - 11
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-001. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Relations; Multiple Births; Nature Nurture; Schizophrenia. Minor Descriptor: Daughters. Classification: Schizophrenia & Psychotic States (3213); Genetics (2510). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11. 
AB  - This book is essentially the historical account and clinical evaluation of a single family. As such it is primarily a case study, although its protagonists number six persons rather than one (a father and mother and identical quadruplet daughters who were schizophrenic in varying degrees). In an age when scientific methods have been developed in profusion and applied with considerable sophistication and self-consciousness to the study of behavior or behavioral disorder, it seems almost anachronistic to proffer to the scientific community a case study as a serious contribution to the advancement of psychological or psychiatric thought. A scientist who finds himself venturing such a claim must surely deem it judicious, if not actually compelling, to reflect on why he should attribute special importance to any single case, let alone to one in which he is personally invested. Specifically, I have asked myself two questions. First, what marks the case method as distinctive; what special features must a case or case study possess to give it special significance? Second, what special features do we find in our study of the Genain family that might give it a claim to scientific attention? (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - Genain family
KW  - quadruplet daughters
KW  - schizophrenia
KW  - 1963
KW  - Family Relations
KW  - Multiple Births
KW  - Nature Nurture
KW  - Schizophrenia
KW  - Daughters
KW  - 1963
DO  - 10.1037/11420-001
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-003
AN  - 2007-02259-003
AU  - Rosenthal, David
AU  - Raphling, Lois S.
AU  - Quinn, Olive W.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Anamnesis.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 22
EP  - 149
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-003. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Background; Family Relations; Multiple Births; Patient History; Schizophrenia. Minor Descriptor: Birth; Daughters; Fathers; Marriage; Mothers; Parents. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 128. 
AB  - This chapter entitled anamnesis begins by discussing the early years of Henry Genain and of Gertrude Hood Genain. It then looks at the courtship and early marriage of Henry and Gertrude. Next, it discusses the birth of the quadruplets. The chapter goes on to describe the quads' preschool years, elementary years, junior-high school years, high-school years, and post-school years. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - Gertrude Hood Genain
KW  - Henry Genain
KW  - quadruplets
KW  - schizophrenia
KW  - preschool years
KW  - elementary years
KW  - junior high school years
KW  - high school years
KW  - post school years
KW  - birth
KW  - marriage
KW  - family background
KW  - 1963
KW  - Family Background
KW  - Family Relations
KW  - Multiple Births
KW  - Patient History
KW  - Schizophrenia
KW  - Birth
KW  - Daughters
KW  - Fathers
KW  - Marriage
KW  - Mothers
KW  - Parents
KW  - 1963
DO  - 10.1037/11420-003
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-004
AN  - 2007-02259-004
AU  - Rosenthal, David
AU  - Quinn, Olive W.
AU  - Raphling, Lois S.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - The NIH Years.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 150
EP  - 160
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-004. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Multiple Births; Psychiatric Hospitalization; Psychotherapy; Schizophrenia. Minor Descriptor: Daughters; Living Arrangements; Parents. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 11. 
AB  - The quads remained at NIH for three years. There was much discussion about whether the girls should live on the same or different wards or, if on the same ward, whether in the same or in different dormitories, in pairs or separately. Consequently, various living arrangements were tried. Each girl was assigned a different psychiatrist who was responsible for her treatment. No physical or drug therapy was given them, but they were encouraged to take advantage of the psychotherapy offered. While the girls lived at the Clinical Center, Mr. and Mrs. Genain visited them repeatedly, first for a month when the girls were admitted, and most other times for one-week periods. During these visits, they lived at the Clinical Center with their daughters. Each parent was assigned a social caseworker. During the periods between visits, Mrs. Genain's worker conducted interviews by telephone. Some of the main observations made on the separate members of the family are presented in this chapter. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - NIH Clinical Center
KW  - Genain quadruplets
KW  - Genain family
KW  - psychotherapy
KW  - schizophrenia
KW  - living arrangements
KW  - 1963
KW  - Multiple Births
KW  - Psychiatric Hospitalization
KW  - Psychotherapy
KW  - Schizophrenia
KW  - Daughters
KW  - Living Arrangements
KW  - Parents
KW  - 1963
DO  - 10.1037/11420-004
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-006
AN  - 2007-02259-006
AU  - Rosenthal, David
AU  - Quinn, Olive W.
AU  - Raphling, Lois S.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Follow-up.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 169
EP  - 175
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-006. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Adjustment; Multiple Births; Prognosis; Psychiatric Hospitalization; Schizophrenia. Minor Descriptor: Sisters; Treatment. Classification: Schizophrenia & Psychotic States (3213); Inpatient & Hospital Services (3379). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 7. 
AB  - This chapter describes followup with each of the Genain quadruplets. First, the chapter looks at Myra after she left Woodley House. The chapter then describes Nora, Iris, and Hester's time after leaving NIH and being admitted to Kenwood State Hospital. Nora was able to leave the hospital and marry. Though her course of adjustment has been marginal and uneven, the prospects of her remaining out of the hospital are reasonably good. During her better phases, Iris was permitted home visits for brief periods. Mrs. Genain and hospital personnel do not feel that she is well enough yet to live at home. The prognosis is guarded, but somewhat pessimistic. Hester, however, has never been home on leave and remains on a regressed ward. Her prognosis is poor. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - Genain quadruplets
KW  - hospitalization
KW  - followup
KW  - adjustment
KW  - prognosis
KW  - 1963
KW  - Adjustment
KW  - Multiple Births
KW  - Prognosis
KW  - Psychiatric Hospitalization
KW  - Schizophrenia
KW  - Sisters
KW  - Treatment
KW  - 1963
DO  - 10.1037/11420-006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-007
AN  - 2007-02259-007
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Psychiatric Disorders in the Families of Mr. and Mrs. Genain.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 176
EP  - 178
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-007. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Background; Mental Disorders; Patient History; Psychopathology. Minor Descriptor: Multiple Births; Offspring; Parents. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 3. 
AB  - Mrs. Genain's notebook contained the dates of birth and death and some fragments of medical or marital history of her husband's relatives and her own. We obtained additional information primarily through interviews with her. In the main, she portrayed her husband's family as abounding with various forms of psychopathology and her own family as being virtually free of mental disorders. The sharp contrast immediately raises questions about the accuracy of her reporting, but details of life history such as marital status, stability and fruitfulness of marriage, occupational history, manner of death, and some corroborative history by Henry's brother Raymond all suggest that though she may have accentuated or exaggerated various highlights of history to achieve the portrait of contrast, the general picture is essentially correct. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - psychiatric disorders
KW  - family history
KW  - Mr. & Mrs. Genain
KW  - psychopathology
KW  - 1963
KW  - Family Background
KW  - Mental Disorders
KW  - Patient History
KW  - Psychopathology
KW  - Multiple Births
KW  - Offspring
KW  - Parents
KW  - 1963
DO  - 10.1037/11420-007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-008
AN  - 2007-02259-008
AU  - Allen, Gordon
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Zygosity of the Quadruplets.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 181
EP  - 192
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-008. Partial author list: First Author & Affiliation: Allen, Gordon; Section on Community and Population Studies, Laboratory of Socio-Environmental Studies, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Genetics; Heterozygotic Twins; Monozygotic Twins; Multiple Births. Minor Descriptor: Schizophrenia; Sisters. Classification: Genetics (2510); Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 12. 
AB  - Previous investigators, who studied the placenta, early physical resemblances, and qualitative features regard the Genain quadruplets as monozygotic. The addition of blood group tests to the criteria now tends to confirm the earlier conclusion. When probabilities are calculated by a modification of methods devised for twins, simple hereditary traits yield a probability above 99 per cent that the quadruplets are monozygotic. Some quantitative differences, especially fingerprints, appear more consistent with a two-egg origin, but statistics on these traits in other quadruplets do not exist. The evidence from qualitative traits so strongly supports the monozygotic hypothesis that the observed quantitative differences can probably be taken as a measure of the variation that is possible in identical quadruplets. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - zygosity
KW  - Genain quadruplets
KW  - monozygotic vs dizygotic
KW  - 1963
KW  - Genetics
KW  - Heterozygotic Twins
KW  - Monozygotic Twins
KW  - Multiple Births
KW  - Schizophrenia
KW  - Sisters
KW  - 1963
DO  - 10.1037/11420-008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-009
AN  - 2007-02259-009
AU  - Bayley, Nancy
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Intellectual and Physical Development.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 193
EP  - 201
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-009. Partial author list: First Author & Affiliation: Bayley, Nancy; Section on Early Development, Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Academic Achievement; Intellectual Development; Multiple Births; Physical Development; Schizophrenia. Minor Descriptor: Intelligence; Intelligence Measures; Test Scores. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Arthur performance test; Henman-Nelson intelligence test; Wechsler Bellevue Intelligence Scale; Otis-Lennon School Ability Test; Stanford-Binet Intelligence Scale; Army Beta Examination. Methodology: Clinical Case Study; Empirical Study. Page Count: 9. 
AB  - There is a considerable body of literature on the status of intellectual ability in the mental disorders. After an extensive, recent review of the topic, Payne (1961) stated that 'the bulk of the literature relates test results to psychiatric labels, and not to specific symptoms rated independently by unbiased observers, nor to other unambiguous data about the patients. Therefore it will be difficult to interpret most of the studies. Even if some correlations with psychiatric labels are observed, the reasons for these will not be clear. The behavioral correlates of specific cognitive dysfunctions can only be speculated about from the data so far available in the literature.' The quadruplets afford us an opportunity to compensate for some of the deficiencies to which Payne refers, in that the data about them are extensive and unambiguous, especially the data on their clinical condition during their illness. Moreover, their heredity is identical so that we do not have to be troubled by the possible contributions to current performance of differences in native endowment. This chapter presents intelligence test scores, school records, and physical growth records for the Genain quadruplets and discusses their results. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - intellectual & physical development
KW  - intelligence tests
KW  - Genain quadruplets
KW  - school records
KW  - physical growth
KW  - 1963
KW  - Academic Achievement
KW  - Intellectual Development
KW  - Multiple Births
KW  - Physical Development
KW  - Schizophrenia
KW  - Intelligence
KW  - Intelligence Measures
KW  - Test Scores
KW  - 1963
DO  - 10.1037/11420-009
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-010
AN  - 2007-02259-010
AU  - Evarts, Edward V.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Electroencephalographic Studies of the Genain Family.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 202
EP  - 207
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-010. Partial author list: First Author & Affiliation: Evarts, Edward V.; Section on Physiology, Laboratory of Clinical Science, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Electroencephalography; Family Members; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 6. 
AB  - EEG records were obtained once for Mr. and Mrs. Genain and several times over a period of two years for their four children. Records were obtained on a standard eight-channel machine, employing the electrode placements and recording combinations described by Cohn (1949). The results of these EEG exams are presented in this chapter, as well as a comment on the findings. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - electroencephalographic records
KW  - Genain family
KW  - 1963
KW  - Electroencephalography
KW  - Family Members
KW  - Schizophrenia
KW  - 1963
DO  - 10.1037/11420-010
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-011
AN  - 2007-02259-011
AU  - Zahn, Theodore P.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - GSR Responsivity.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 208
EP  - 216
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-011. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Members; Galvanic Skin Response; Psychophysiology; Schizophrenia. Minor Descriptor: Skin Resistance. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 9. 
AB  - Many theories about the etiology of schizophrenia have focused on 'anxiety' or some state of hyperexcitability as a key variable. Its degree of presence is sometimes estimated clinically, sometimes on the basis of psychophysiological responses under somewhat controlled conditions. Among our early subjects we included the Genain family, but unfortunately, as under many other circumstances, Mr. Genain managed to avoid being tested. This procedure was undertaken in order to gain some notion of the level of arousal and autonomic responsivity of the girls. It involved the continuous measurement of galvanic skin resistance (GSR) during two sessions in which visual or auditory stimuli were presented repetitively. This chapter presents T. P. Zahn's account of the 'orienting' procedure and his analysis of the findings on the Genains. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - psychophysiological responses
KW  - galvanic skin resistance
KW  - Genain family
KW  - schizophrenia
KW  - 1963
KW  - Family Members
KW  - Galvanic Skin Response
KW  - Psychophysiology
KW  - Schizophrenia
KW  - Skin Resistance
KW  - 1963
DO  - 10.1037/11420-011
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-012
AN  - 2007-02259-012
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Reaction time.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 217
EP  - 221
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-012. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Members; Reaction Time; Schizophrenia. Minor Descriptor: Multiple Births. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 5. 
AB  - Probably no other laboratory procedure has as long a history, or has been applied to the psychological analysis of schizophrenia as often, as has the reaction time experiment. It has been shown again and again, in many different contexts, that groups of schizophrenic subjects respond motorically to a signal more slowly than groups of normal subjects. We originally intended to do several experiments with the Genian quadruplets, including the effects on set index of clinical conditions when heredity is controlled, and the relation of heredity and clinical condition to reaction time (RT) tasks of varying complexity. Unfortunately, Iris and Hester were unable to cooperate in the task and the plans had to be abandoned. A description of their behavior in the context of the reaction time situation is presented to give the reader a first-hand account of their response in a common novel setting which both experienced as stressful. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - reaction time situation
KW  - schizophrenia
KW  - Genain quadruplets
KW  - 1963
KW  - Family Members
KW  - Reaction Time
KW  - Schizophrenia
KW  - Multiple Births
KW  - 1963
DO  - 10.1037/11420-012
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-014
AN  - 2007-02259-014
AU  - Rosenthal, David
AU  - Lewinson, Thea Stein
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Handwriting of the Quadruplets during Morbid and Premorbid Conditions.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 227
EP  - 240
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-014. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Handwriting; Personality; Premorbidity; Schizophrenia. Minor Descriptor: Evaluation; Multiple Births; Sisters. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 14. 
AB  - The scientific status of handwriting analysis as a way of evaluating personality or psychopathology is still unsettled. Types of analysis have been classified as intuitive and objective. Mrs. Lewinson is one of the foremost exponents of objective analysis, which is based on a number of readily measurable signs We intended to ask an expert to provide the analysis without knowing anything about the subjects. Mrs. Lewinson graciously agreed to such an arrangement. Unfortunately, because of an accident of communication, she learned that the subjects were schizophrenic identical quadruplets and we had to revise our plans. However, Mrs. Lewinson knew nothing more than that about the girls or their histories. After she had made her reports and ratings based on the girls' high school handwriting specimens, we submitted to her a second group of samples, obtained while the girls were hospital patients (ages twenty-eight to twenty-nine). We deliberately did not tell Mrs. Lewinson which of the four later samples corresponded to the four earlier ones. But the attempt to preserve even this much anonymity proved pointless; Mrs. Lewinson immediately matched, correctly and with complete confidence, the earlier and later samples. For each handwriting sample, Mrs. Lewinson was to present graphs descriptive of the subject's personality and psychopathology in five areas of functioning, according to formulations which she has developed and presented elsewhere (Lewinson and Zubin, 1942; Lewinson, 1961). She was also asked to write a full personality evaluation and to rate each subject on sixty selected traits. A summary of the personality evaluations and an analysis of the ratings are presented here. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - schizophrenic quadruplets
KW  - handwriting analysis
KW  - personality evaluations
KW  - premorbid & morbid conditions
KW  - 1963
KW  - Handwriting
KW  - Personality
KW  - Premorbidity
KW  - Schizophrenia
KW  - Evaluation
KW  - Multiple Births
KW  - Sisters
KW  - 1963
DO  - 10.1037/11420-014
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-016
AN  - 2007-02259-016
AU  - Kendig, Isabelle V.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - The Draw-a-Person Test.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 257
EP  - 268
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-016. Partial author list: First Author & Affiliation: Kendig, Isabelle V.; National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Drawing; Personality Traits; Projective Personality Measures; Schizophrenia. Minor Descriptor: Multiple Births; Siblings. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 12. 
AB  - The Draw-a-Person test is given mostly for diagnostic purposes and for evaluating various personality traits, such as self-image, sexual identification, feelings of insecurity, etc. As is true of many projective tests, the material elicited often has high impact and interest value, and when first confronted by the drawings, one often experiences a sense of surprise or revelation. However, attempts to obtain consensus or validation regarding the meaning of the material obtained are usually less than satisfactory. Nevertheless, since the Draw-a-Person test enjoys such widespread clinical use, is usually obtainable from subjects who cannot or will not perform on other tests, and has intrinsic interest because of the material it provides, we gave the test to the Genain girls. Two of the girls were testable when they first arrived at the Clinical Center. Subsequently Dr. Kendig, with great clinical skill, was able to test all four. This chapter provides Dr. Kendig's clinical evaluation of the drawings obtained at the earlier testings and those she obtained herself. I asked Dr. Kendig to summarize the similarities and differences in the girls' performance and to make ratings of various personality characteristics based on the girls' test performance. However, she preferred not to make the kind of inferences involved in the latter task. The reader may examine the drawings and Dr. Kendig's account of them and make his own comparisons and interpretations, if he is so inclined. Two points are clear. The drawings vary markedly from girl to girl and from time to time in the case of Myra and Nora; but a few similarities can be detected, as between Myra's first female figure and Iris' male figure, or the hands drawn by Myra and the hands drawn by Iris. Yet it is evident that the character of the drawings is far more sensitive to the clinical condition of the girls than to any genetic factors, whether the latter are the ones that may bear on the schizophrenic process or not. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - projective tests
KW  - Draw-a-Person test
KW  - schizophrenia
KW  - personality characteristics
KW  - 1963
KW  - Drawing
KW  - Personality Traits
KW  - Projective Personality Measures
KW  - Schizophrenia
KW  - Multiple Births
KW  - Siblings
KW  - 1963
DO  - 10.1037/11420-016
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-018
AN  - 2007-02259-018
AU  - Rosenthal, David
AU  - Piotrowski, Zygmunt A.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - The Beck-Molish Rorschach Typology with Respect to the Genain Family.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 307
EP  - 314
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-018. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Members; Multiple Births; Nature Nurture; Schizophrenia. Minor Descriptor: Environment; Evaluation; Testing. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Beck-Molish Q-sort evaluation. Methodology: Clinical Case Study; Empirical Study. Page Count: 8. 
AB  - Rorschach's Psychodiagnostik first appeared in 1921. Eight years later, M. Bleuler (1929) published the first article purporting to show whether hereditary as well as environmental factors influenced performance on 'Rorschach's experiment.' In a subsequent article which appeared in the first volume of Character and Personality (1933), he summarized his findings. In this chapter, we shall open again the original question raised by Bleuler, this time however using a method which evaluates the entire record in the integrative fashion recommended. The following is an account of how the study was done, its rationale, and the results we obtained. After Dr. Piotrowski had completed his analyses of the sixteen protocols submitted to him, he was told that ten of the protocols belonged to members of the same family and that some records represented repeated testings of the same person. He was also told that the family was a most unusual one, but nothing was said about what made it unusual, nor did Dr. Piotrowski guess at any time that a multiple birth was involved. It was suggested that before we told him the whole story about the family, we should have a Beck-Molish Q-sort evaluation of each record. Although the Q-sorting is an onerous task, and although he knew nothing about the reason for doing it, Dr. Piotrowski went along with the suggestion. The Q-type descriptions which he provided represent the raw data of this chapter. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - multiple birth
KW  - Beck-Molish Q-sort evaluation
KW  - environmental factors
KW  - Genain family
KW  - heredity
KW  - 1963
KW  - Family Members
KW  - Multiple Births
KW  - Nature Nurture
KW  - Schizophrenia
KW  - Environment
KW  - Evaluation
KW  - Testing
KW  - 1963
DO  - 10.1037/11420-018
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-036
AN  - 2007-02259-036
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Possible environmental factors: Life-experience.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 347
EP  - 374
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-036. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Anxiety Management; Cognitive Processes; Life Experiences; Schizophrenia; Socialization. Minor Descriptor: Anxiety; Daughters; Environment; Failure; Family; Fathers; Multiple Births; Psychological Theories; Sisters. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 28. 
AB  - The history of the Genain family is fairly detailed and most of it is well documented, but in fact it represents only a minute, fragmented, secondhand account of six people's lives. Compared to other case histories, it stands up well. Compared to an ideal that we would all like to achieve, it leaves much to be desired. Even so, it is a simple matter to glean evidence from the history to support almost any of the currently favored psychological theories. Dr. Perlin has pointed to the symbiosis between Myra and her mother. Wynne et al. (1957) have described the pattern of pseudo-mutuality in the family. Mrs. Basamania has indicated how Mrs. Genain's relationship to each of her daughters derived from one of her own unresolved childhood conflicts. The history imparts the picture of a dominant mother who runs the family, and a weak father who cannot cope with her except through threat of violence and who cannot represent a major link between the family and the community. We have clear evidence of double-binding and have provided quotes at different points in the text to illustrate it. Patterns of 'irrationality' are clearly visible in both parents, with indications of the ways the girls became caught up in these patterns. Each quad is a picture of gradually accelerating and expanding anxiety, and the ways the environment contributed to it are shown for each quad. The problem is not to find evidence in the history that such or other relevant events did in fact occur, but rather to determine which, if any, contributed to the development of schizophrenic reactions in the quads. If for the moment we ignore the specific details of the many dynamic or psychological theories proposed to date, we can group them in at least three ways, all of which represent a kind of failure of learning: (1) failure of socialization; (2) failure of cognitive integration; (3) failure to contain anxiety. The three are clearly interrelated, but the focus in each is on one variable which is seen to be primary in the progression of schizophrenic illness, the other two developing secondarily as concomitant effects of the primary condition. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - schizophrenia
KW  - Genain family
KW  - quadruplet sisters
KW  - life experiences
KW  - failure
KW  - socialization
KW  - cognitive integration
KW  - anxiety control
KW  - 1963
KW  - Anxiety Management
KW  - Cognitive Processes
KW  - Life Experiences
KW  - Schizophrenia
KW  - Socialization
KW  - Anxiety
KW  - Daughters
KW  - Environment
KW  - Failure
KW  - Family
KW  - Fathers
KW  - Multiple Births
KW  - Psychological Theories
KW  - Sisters
KW  - 1963
DO  - 10.1037/11420-036
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-022
AN  - 2007-02259-022
AU  - Quinn, Olive W.
AU  - Stein, Johanna
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Social Interaction Patterns of the Quadruplets.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 373
EP  - 387
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-022. Partial author list: First Author & Affiliation: Quinn, Olive W.; Goucher College, Towson, MD, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Hospitalized Patients; Psychiatric Patients; Schizophrenia; Social Behavior; Social Interaction. Minor Descriptor: Multiple Births; Sisters. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Female (40); Inpatient (50). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study; Qualitative Study. Page Count: 15. 
AB  - Observation of the quads' ward behavior was undertaken to describe systematically each girl's social behavior. Did the girls differ in this respect? Was there a functioning hierarchy? Were there observable subgroups? Isolates? The observations were conducted when each quad was residing in a separate room with a nonquad roommate; this arrangement eliminated the involuntary associations produced when sisters were roommates. Each subject was observed for comparable time periods for a sample week of three days: (1) a week day in which the subject had therapy; (2) a week day on which the subject did not have therapy; and (3) a week-end day, when staff and activities were different. The following kinds of information were coded from the observation record: 1. All interactive behavior initiated and received by the quad in focus. Behavior directed to or received from another quad was so specified; for others only the class of individual was specified, i.e., staff member, observer, or patient. 2. The content and affect of interaction, including interactions that called for but did not receive a response. 3. The quads' noninteractive behavior, including nondirected gestures or speech. 4. The setting and all persons potentially available for interaction. 5. Periodic time checks, in which the observer records either that the quad is not doing anything or is continuing an action recorded earlier in the same observation unit. Findings on the following are presented: general frequency of observed behavior, interaction at varied social distance, interaction patterns among quadruplets; quad-quad behavior. A synthesis and interpretation is presented of triads, dyads, and isolation and freedom. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - social interaction
KW  - Genain quadruplets
KW  - social behavior
KW  - ward behavior
KW  - sisters
KW  - schizophrenia
KW  - 1963
KW  - Hospitalized Patients
KW  - Psychiatric Patients
KW  - Schizophrenia
KW  - Social Behavior
KW  - Social Interaction
KW  - Multiple Births
KW  - Sisters
KW  - 1963
DO  - 10.1037/11420-022
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-023
AN  - 2007-02259-023
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Ratings of Disturbance in Various Categories of Behavior during Hospitalization.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 388
EP  - 397
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-023. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Behavior; Hospitalization; Schizophrenia. Minor Descriptor: Etiology; Multiple Births; Sisters. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Female (40); Inpatient (50). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study; Quantitative Study. Page Count: 10. 
AB  - Clearly, the most critical problem surrounding the etiology of schizophrenia from a biological point of view is: If something is inherited in schizophrenia, what is it? The question is generally approached in either of two ways. The first begins with a theoretical view of schizophrenia: for example, viewing the illness as the consequence of failure to adapt on a biological level to stressful situations. This view would hold it reasonable to be concerned with the metabolites of epinephrine and norepinephrine, which are the main humoral mediators of an organism's response to stress. One's search would be concerned with all the metabolic pathways in which these hormones are involved, with discovering a particular point in the metabolic process at which a breakdown or blockage of the process occurs in schizophrenic subjects (Hoffer, Osmond, and Smythies, 1954) and then determining if it is the tendency to develop this particular aberrancy which is inherited. As yet, no such point has been found, but this kind of search is being vigorously pursued on many fronts (Kety, 1959a, 1959b). The second approach begins with a clinical rather than a theoretical view of schizophrenia. It concerns itself with the patterns or sequences of symptomatology which occur in widely diverse forms in the disorders called schizophrenic. The aspects of the illness studied include time of onset, kind or degree of thinking disturbance, psychomotor deviations, the occurrence of particular symptoms or clusters of symptoms, emotional anomalies, Kraepelinian or other subtypes, the tendency toward deteriorative or nondeteriorative outcomes, and so on. Research in this instance is concerned with whether such aspects of the illness are closely associated in twins or families in a pattern of quantitative relationships, which would offer support to the view that these aspects are indeed inherited. The literature on this subject is so varied in substance and method that no one has yet attempted a detailed systematic integration of it, although a few partial summaries are available (Slater, 1947; Planansky, 1955; Rosenthal, 1959). This is not the place to attempt such an integration, although in Part VI I shall discuss in fair detail some of these issues that have special relevance to the findings on the Genains. The report in this chapter is particularly germane to this problem. It is based on a quantitative evaluation of various behavioral disturbances found in the quadruplets while they were hospitalized at the Clinical Center. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - behavior disturbances
KW  - Genain quadruplets
KW  - schizophrenia
KW  - hospitalization
KW  - etiology
KW  - 1963
KW  - Behavior
KW  - Hospitalization
KW  - Schizophrenia
KW  - Etiology
KW  - Multiple Births
KW  - Sisters
KW  - 1963
DO  - 10.1037/11420-023
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-024
AN  - 2007-02259-024
AU  - Schaefer, Earl S.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Parent-Child Interactional Patterns and Parental Attitudes toward Child-Rearing.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 398
EP  - 430
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-024. Partial author list: First Author & Affiliation: Schaefer, Earl S.; Section on Early Development, Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Childrearing Practices; Multiple Births; Parent Child Relations; Parental Attitudes; Schizophrenia. Minor Descriptor: Daughters; Fathers; Mothers. Classification: Schizophrenia & Psychotic States (3213); Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 33. 
AB  - In recent years, several different kinds of studies have been done to evaluate the contribution of parents' behavior to the subsequent development of schizophrenic reactions in their offspring. Some studies have been based on the reports of the patients themselves (Reichard and Tillman, 1950; Limentani, 1956; Kohn and Clausen, 1956), some on the reports and observations of the parents during fairly intensive interviews (Gerard and Siegel, 1950; Tietze, 1949; Alanen, 1958). Several have obtained expressed attitudes about formally written items, as in attitude scales, comparing the parents of schizophrenic and of nonschizophrenic subjects with respect to these verbally expressed attitudes (Shoben, 1949; Mark, 1953; Freeman and Grayson, 1955). Some investigators have tried to make inferences about pathogenic parental behaviors by giving their patients tests involving either attitudes to parents or responses to stimuli depicting parental figures or behaviors (Brecher, 1956; Rodnick and Garmezy, 1957; Lidz, Cornelison, Fleck, and Terry, 1958). One investigator confronted both parents of schizophrenic subjects with differences between them in expressed child-rearing attitudes, and asked them to resolve these differences (Farina, 1960). None of these methods is entirely satisfactory. Ideally, we should like to have firsthand observations of parental behaviors with respect to children who later become schizophrenic and children who do not. In this chapter, we shall be concerned primarily with observations of parent-child interactions made at the Clinical Center. Mr. and Mrs. Genain visited the quadruplets at fairly frequent intervals, the visits lasting from a week to a month at a time. The parents lived in a room on the ward and had ready access to their daughters; they could spend time with them during the day or evening as they wished. Thus, although still artificial and restrictive, the situation nevertheless permitted a wide range of behavior. Topics covered in this chapter include mother-quad interactions, father-quad interactions, father-mother-quad interactions, Mr. Genain's attitudes toward childrearing, discussion of paternal attitudes, Mrs. Genain's attitudes toward child-rearing, and discussion of maternal attitudes. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - schizophrenia
KW  - childrearing attitudes
KW  - parental attitudes
KW  - parent-child interactional patterns
KW  - Genain quadruplets
KW  - 1963
KW  - Childrearing Practices
KW  - Multiple Births
KW  - Parent Child Relations
KW  - Parental Attitudes
KW  - Schizophrenia
KW  - Daughters
KW  - Fathers
KW  - Mothers
KW  - 1963
DO  - 10.1037/11420-024
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-024&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-026
AN  - 2007-02259-026
AU  - Hirsch, Stanley I.
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - A Caseworker's View of Mr. Genain.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 441
EP  - 448
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-026. Partial author list: First Author & Affiliation: Hirsch, Stanley I.; Mental Health Social Service, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Father Child Relations; Marital Relations; Multiple Births; Social Casework. Minor Descriptor: Schizophrenia. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 8. 
AB  - This chapter provides the authors experiences and observations of Mr. Genain. The author became the caseworker for Mr. Genain when Mr. Genain was sixty-six years old. Topics covered in this chapter include his relationship with his wife, relationship to the quads, and casework with Mr. Genain. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - Mr. Genain
KW  - casework
KW  - relationships
KW  - wife
KW  - daughters
KW  - quadruplets
KW  - schizophrenic children
KW  - 1963
KW  - Father Child Relations
KW  - Marital Relations
KW  - Multiple Births
KW  - Social Casework
KW  - Schizophrenia
KW  - 1963
DO  - 10.1037/11420-026
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-030
AN  - 2007-02259-030
AU  - Parloff, Morris B.
AU  - Stephenson, William
AU  - Perlin, Seymour
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Myra's Perception of Self and Others.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 493
EP  - 501
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-030. Partial author list: First Author & Affiliation: Parloff, Morris B.; Section on Personality, Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Morality; Psychotherapeutic Processes; Psychotherapy; Self-Perception; Values. Minor Descriptor: Hospitalization; Multiple Births; Sisters; Therapist Attitudes. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Female (40); Inpatient (50). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Rosenthal Moral Values Q-set; California Q-Sort. Methodology: Clinical Case Study; Empirical Study. Page Count: 9. 
AB  - Although each member of a multiple birth has a problem in establishing his own identity, Myra found the task especially difficult. A goal of therapy was, therefore, to help Myra establish more clearly her own ego boundaries. The study reported here had two main goals: (1) to trace the changes in Myra's consciousness of herself and her perceptions of other persons who played a significant role in her life; (2) to study the nature of the changes in both the patient's and therapist's treatment goals and in the therapist's perception of her. The investigation period covered the first two years of Myra's hospitalization. To determine the nature and modifications of the patient's perceptions of self, family and others, therapy goals, and how she appeared to her family and others, two sets of Q-sort cards with self-referent items were sorted under a number of different instructional sets during a twenty-three-month therapy period. The therapist also sorted the two Q-decks to describe Myra's attitudes and behaviors, his treatment goals for her, and his expectations of how Myra would describe him. Based on the Principal Components analysis of both Q-set matrices, Myra appears to perceive her mother as the member of the family most congenial to her. Myra's father and sisters, in contrast, are alien to her in that they appear on components characterized by pathology and rigid morality. Myra is able to identify with her mother and views her as representing attitudes and behaviors which Myra hopes to achieve in psychotherapy. However, Myra views these attitudes as representing male attitudes and prerogatives. She perceives the family as sharing a rather formidable set of values. Myra believed that her family and her therapist perceived her in quite different ways, neither of these personae was in accord with her own view of herself. On neither Q-set do the patient and therapist appear to have come to any agreement regarding the goals of treatment, perhaps because the therapist in his analytic role remained a fairly ambiguous figure. Perhaps the most significant finding lies not in the nature of the components defined but in the fact that Myra could not attribute her picture of her attitudes and behavior (California Q-set) to anyone outside herself, whereas she could do so easily under comparable conditions on the Moral Values Q-set. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - Myra Genain
KW  - Genain quadruplets
KW  - self perception
KW  - perception of others
KW  - therapy goals
KW  - values
KW  - morals
KW  - therapist's perception
KW  - hospitalization
KW  - 1963
KW  - Morality
KW  - Psychotherapeutic Processes
KW  - Psychotherapy
KW  - Self-Perception
KW  - Values
KW  - Hospitalization
KW  - Multiple Births
KW  - Sisters
KW  - Therapist Attitudes
KW  - 1963
DO  - 10.1037/11420-030
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-031
AN  - 2007-02259-031
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - A suggested conceptual framework.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 505
EP  - 511
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-031. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Etiology; Schizophrenia; Theories. Minor Descriptor: Biochemistry; Diathesis Stress Model; Genetics; Life Experiences; Stress. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 7. 
AB  - So many theories of the etiology of schizophrenia (or dementia praecox) have been proposed during the relatively brief time since its postulation and general acknowledgment as a disease entity (1896) that it becomes almost impossible to deal with them separately. Many are in disrepute, or at least out of fashion, and probably better forgotten. Others hang on precariously, sometimes serving as the basis for further research, sometimes providing a basis for a new theory which is often an excrescence on the old. Others continue to be proposed with almost each new discovery about brain anatomy or function, about certain new metabolites or metabolic pathways, newly synthesized drugs which are thought to influence or simulate schizophrenic behavior, and loosely formulated psychological or psychiatric concepts which have often soared into prominence only to be replaced shortly in general favor by others which the rapidly changing professional temper has somehow found more congenial. For purposes of our discussion, these varied proposals may be grouped in three ways to provide at least the semblance of a conceptual framework in which to consider with greater effect the many findings on the Genains. The three types discussed in this chapter are monogenic-biochemical theories, diathesis-stress theories, and life experience theories. The chapter closes with a discussion of the problem of multiple etiologies. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - schizophrenia
KW  - etiology
KW  - conceptual framework
KW  - theories
KW  - monogenic-biochemical & diathesis-stress & life experience theories
KW  - 1963
KW  - Etiology
KW  - Schizophrenia
KW  - Theories
KW  - Biochemistry
KW  - Diathesis Stress Model
KW  - Genetics
KW  - Life Experiences
KW  - Stress
KW  - 1963
DO  - 10.1037/11420-031
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-031&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-032
AN  - 2007-02259-032
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Possible Inherited Factors: EEG Abnormality.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 512
EP  - 516
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-032. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Biochemistry; Electroencephalography; Genetics; Schizophrenia; Theories. Minor Descriptor: Genes; Multiple Births. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - From the point of view of monogenic-biochemical theory, one must be able to cite the specific biochemical imbalance that causes the illness if one is to contribute to basic knowledge. Unfortunately, no studies relevant to such a theory were attempted on the Genains. However, it is probable that such studies are better done on a variety of schizophrenic subjects, in whom the postulated mutant gene is imbedded in a wide diversity of genotypes, thereby minimizing the confounding of the implicated genetic effect with effects due to a common overall genotype, as in monozygotic twins or quadruplets. Thus, any findings of this study which suggest that there are inherited factors involved in the illness must either be considered as secondary signs of such a biochemical imbalance or as supportive of diathesis-stress theory. This chapter explores electroencephalographic abnormality. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - monogenic-biochemical theory
KW  - schizophrenic subjects
KW  - electroencephalographic abnormality
KW  - Genain quadruplets
KW  - 1963
KW  - Biochemistry
KW  - Electroencephalography
KW  - Genetics
KW  - Schizophrenia
KW  - Theories
KW  - Genes
KW  - Multiple Births
KW  - 1963
DO  - 10.1037/11420-032
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-032&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-033
AN  - 2007-02259-033
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Possible Inherited Factors: Clinical Features of Schizophrenic Illness.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 517
EP  - 529
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-033. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Disease Course; Genetics; Onset (Disorders); Schizophrenia; Subtypes (Disorders). Minor Descriptor: Multiple Births; Treatment Outcomes. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 13. 
AB  - Unfortunately, there has been a paucity of studies dealing with separate aspects of clinical schizophrenia from the standpoint of heredity. We will briefly review some of the main ones relevant to the Genains, including: subtypes; age of onset; and, course and outcome. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - inherited factors
KW  - clinical schizophrenia
KW  - heredity
KW  - Genain quadruplets
KW  - subtypes
KW  - age of onset
KW  - course
KW  - outcome
KW  - 1963
KW  - Disease Course
KW  - Genetics
KW  - Onset (Disorders)
KW  - Schizophrenia
KW  - Subtypes (Disorders)
KW  - Multiple Births
KW  - Treatment Outcomes
KW  - 1963
DO  - 10.1037/11420-033
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-034
AN  - 2007-02259-034
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Possible Inherited Factors: Patterns of Behavioral Disturbance, Premorbid Personality, and Test Performance.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 530
EP  - 540
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-034. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Behavior Problems; Genetics; Performance; Personality; Schizophrenia. Minor Descriptor: Handwriting; Intelligence; Multiple Births; Premorbidity; Test Performance. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11. 
AB  - Do the sequences of catatonic-hebephrenic progression and the patterns of behavioral disturbance during schizophrenic psychosis reflect a continuation and exacerbation of prepsychotic personality traits which may themselves have some hereditary basis? If so, we would have additional support for diathesis-stress theory, and at a practical level, we should be able to predict from the behavioral patterns of early childhood whether a given child would manifest a predominantly catatonic-hebephrenic syndrome if he became overtly schizophrenic or not. How can we possibly identify these personality characteristics of the Genain children which may have been harbingers of schizophrenia due in large part to heredity? The best we can hope to do is to indicate those personality characteristics which all the people who knew them attributed to all four girls, to determine from the literature whether there are indications that such traits are influenced by heredity, and to evaluate the evidence indicating that such traits are associated with the occurrence of clinical schizophrenia. The traits we would be most directly concerned with would be the ones which were prominent during the girls' subsequent psychosis, traits involving underactivity, verbal constriction, depressiveness, and social avoidance behavior, all implying excessive constraint or inhibition of response. From the many interviews of teachers, acquaintances, and relatives of the girls, we found that the kinds of adjectives used to describe all four included: not much energy, frail, pallid, tired easily; not forward, not aggressive, sweet, quiet, sedate, nice, reserved but outwardly friendly, no initiative, did what they were told, not popular, stand-offish, liked to be by themselves; scared, fearful, anxious, hard-working. A section on characteristics of performance and response brings together and summarizes briefly the main findings relevant to the possible inheritance of performance with respect to the procedures employed in studying the Genains. We are primarily concerned with those aspects that may have relevance to the development of schizophrenic illness. Topics covered in this section include handwriting, intelligence, and test responses. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - premorbid personality
KW  - inherited factors
KW  - behavior disturbance
KW  - test performance
KW  - Genain quadruplets
KW  - handwriting
KW  - schizophrenia
KW  - intelligence
KW  - 1963
KW  - Behavior Problems
KW  - Genetics
KW  - Performance
KW  - Personality
KW  - Schizophrenia
KW  - Handwriting
KW  - Intelligence
KW  - Multiple Births
KW  - Premorbidity
KW  - Test Performance
KW  - 1963
DO  - 10.1037/11420-034
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-034&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-035
AN  - 2007-02259-035
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - Possible environmental factors: Prenatal influences.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 541
EP  - 546
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-035. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Environment; Prenatal Development; Schizophrenia. Minor Descriptor: Etiology; Life Experiences; Multiple Births; Stress. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 6. 
AB  - Although the literature on the genetics of schizophrenia is extensive, unwieldy, and inconclusive, our knowledge of environmental factors as possible etiologic agents in schizophrenia is based largely on precarious inferences from clinical case histories, epidemiological and ecological surveys, interviews of families, psychotherapy reports, and experimental studies on the psychology of schizophrenic patients. This literature taken en masse is truly forbidding, and makes the genetics literature seem almost unitary and lucid by comparison. Although the psychotherapy and case reports sometimes have a convincing ring, they are based on arbitrarily selected cases in which the possible effects of endogenous factors are usually not considered. The theorizing about such cases still reflects schools of thought--Freudian, Meyerian, Sullivanian, Jungian, Rogerian, existentialist--and often involves conjecture, dogma, and loose theorizing as much as thought (Rosenthal, 1961b). Among the better done epidemiological and ecological studies, the findings reported could easily be interpreted to be consistent with a genetic theory of schizophrenia. The experimental studies on the psychology of schizophrenia seem often to go counter to one another, and even if we consider only those findings that are consistent with a possible psychological etiology, the inference that current performance during the psychotic state accurately reflects early actual experiences which in turn brought on the psychosis is clearly saltatory. I will not repeat here the comments in my introductory note to Dr. Schaefer's analysis of parent-child interaction, where I reflected briefly on the problems of methodology and interpretation in family studies of schizophrenia. All things considered, I can see little profit in reviewing bodies of literature relevant to points about the Genains when considering possible psychogenic factors, as I did when discussing possible genetic factors. I shall try, however, to evaluate briefly our knowledge about possible prenatal factors in schizophrenia, considering their relevance to the illness in the quads. Then I shall cursorily examine the case history material and the various studies on the Genains, profiting as I can from the analyses and thinking of my fellow contributors, and highlight the kinds of stresses or life experiences that may have been implicated in the different courses of illness observed in the quadruplets. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - prenatal influences
KW  - environmental factors
KW  - schizophrenia
KW  - Genian quadruplets
KW  - stresses
KW  - life experiences
KW  - 1963
KW  - Environment
KW  - Prenatal Development
KW  - Schizophrenia
KW  - Etiology
KW  - Life Experiences
KW  - Multiple Births
KW  - Stress
KW  - 1963
DO  - 10.1037/11420-035
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-02259-037
AN  - 2007-02259-037
AU  - Rosenthal, David
ED  - Rosenthal, David
ED  - Rosenthal, David, (Ed)
T1  - The Nature of the Heredity-Environment Interaction.
T2  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
SP  - 575
EP  - 579
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-037. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Nature Nurture; Schizophrenia. Minor Descriptor: Environment; Genetics. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - I have not read or talked to any serious investigator of the heredity-environment problem in schizophrenia who has not in some way or other indicated that, in his opinion, both contributed to the disorder. The disagreements usually have arisen in regard to the relative importance attached to each and the kinds of genetic or environmental factors thought to be involved. Those who emphasize the genetic contribution seldom consider in earnest the role that environment might play, and environmentalists usually pay lip service to the idea that hereditary factors may eventually have to be considered as well. A theoretical reconciliation of the two is not easily effected. I should like here to present briefly several models of heredity-environment interaction that are implicit in various theories of schizophrenia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - heredity-environment interaction
KW  - environmental factors
KW  - hereditary factors
KW  - genetic contribution
KW  - schizophrenia
KW  - theories
KW  - 1963
KW  - Nature Nurture
KW  - Schizophrenia
KW  - Environment
KW  - Genetics
KW  - 1963
DO  - 10.1037/11420-037
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-037&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - BOOK
ID  - 2007-02259-000
AN  - 2007-02259-000
AU  - Rosenthal, David
ED  - Rosenthal, David
T1  - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia.
Y1  - 1963///
CY  - New York, NY, US
PB  - Basic Books
N1  - Accession Number: 2007-02259-000. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Family Relations; Genetics; Multiple Births; Nature Nurture; Schizophrenia. Minor Descriptor: Environment; Family Members. Classification: Schizophrenia & Psychotic States (3213); Genetics (2510). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. References Available: Y. Page Count: 609. 
AB  - This book focuses on the Genian quadruplets, all of whom were schizophrenic. The book could have been written in many ways. The case history material could have been presented by themes or topics, such as intrafamilial relationships, sexuality, dependency, and so on. Or each quadruplet could have been traced separately, with a later attempt to interrelate the separate histories. But I have decided to present the material chronologically with respect to the family as a unit, trying to recapture the coursing problems, moods, assumptions, and decisions which beset the family members over the years and which eventually entangled them together in a net of circumstances that tightened more and more around each as they struggled to free themselves from it. Since six persons are involved, it is necessary in such a presentation to focus now on one, now on another, in a sense moving the spotlight where the family itself has directed. This may at times make the presentation appear jumpy and uneven, but hopefully it mirrors what actually occurred. The case history comprises the first part of the book. The second part presents tests and studies dealing with some basic characteristics and response processes. The third section consists of various protective tests and their analyses. The fourth involves systematic analyses of observations of the family by NIH staff and by the community. Part five presents some conceptualizations of family members and their interrelationships. Finally, I have presented a theoretical analysis of the heredity-environment problem in schizophrenia, summarizing the basic issues that apply to the Genains and our current knowledge about those issues, and indicating how this study illuminates them. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - heredity
KW  - environment
KW  - Genain quadruplets
KW  - schizophrenia
KW  - intrafamilial relationships
KW  - 1963
KW  - Family Relations
KW  - Genetics
KW  - Multiple Births
KW  - Nature Nurture
KW  - Schizophrenia
KW  - Environment
KW  - Family Members
KW  - 1963
DO  - 10.1037/11420-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rheingold, Harriet L.
AU  - Stanley, Walter C.
T1  - DEVELOPMENTAL PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1963/02//
VL  - 14
IS  - 1
M3  - Article
SP  - 1
EP  - 28
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - The article presents a study on developmental psychology with emphasis on the stimulus control of both human and animal subjects and offers an analysis of learned behavior in immature organisms. It determines the effects of various kinds of deprivation and stimulation. Moreover, it provides an analysis of learned behavior including the types of reinforcers and parameters of reinforcement, discriminative stimulus control, and the role of response.
KW  - DEVELOPMENTAL psychology
KW  - DEVELOPMENTAL biology
KW  - CONDITIONED response
KW  - PSYCHOLOGY of learning
KW  - BEHAVIOR modification
KW  - STIMULUS satiation
N1  - Accession Number: 32898265; Rheingold, Harriet L. 1; Stanley, Walter C. 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 1963, Vol. 14 Issue 1, p1; Subject Term: DEVELOPMENTAL psychology; Subject Term: DEVELOPMENTAL biology; Subject Term: CONDITIONED response; Subject Term: PSYCHOLOGY of learning; Subject Term: BEHAVIOR modification; Subject Term: STIMULUS satiation; Number of Pages: 28p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=32898265&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Butler, Robert N.
T1  - Psychiatric evaluation of the aged.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1963/03//
VL  - 18
IS  - 3
M3  - Article
SP  - 220
EP  - 232
SN  - 0016867X
N1  - Accession Number: 17107737; Butler, Robert N. 1; Source Information: Mar1963, Vol. 18 Issue 3, p220; Number of Pages: 13p; Illustrations: 9 Black and White Photographs, 2 Charts; Document Type: Article; Full Text Word Count: 4741
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17107737&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Harris, T.N.
AU  - Dray, Sheldon
AU  - Ellsworth, Barbara
AU  - Harris, Susanna
T1  - Rabbit Gamma-Globulin Allotypes as Genetic Markers for the Source of Antibody Produced in Recipients of <em>Shigella</em>-Incubated Lymph Node Cells.
JO  - Immunology
JF  - Immunology
Y1  - 1963/03//
VL  - 6
IS  - 2
M3  - Article
SP  - 169
EP  - 178
SN  - 00192805
AB  - Rabbits homozygous for each of an allelic pair of allotypes of γ globulin (A4 and A5) were used as donors and recipients of transferred antigen-incubated lymph node cells, the cells of donors of one allotype being in each case transferred to recipients of the other. When agglutinins to Shigella (the source of the antigen with which the lymph node dells were incubated) appeared in the sera of the recipient animals, the allotype of the agglutinin was determined by adsorbing it to Shigella on a glass slide, then treating the preparations with fluorescein-conjugated rabbit anti-A5-γ-globulin and anti-A4-γ-globulin antisera, respectively. In each case the reactions of the recipients' sera were positive for γ globulin of the donors' allotype but not of their own. Positive reactions were given only by sera above a certain range of agglutinin titre. After sufficient decline of the agglutinin level in the sera of the recipients, these animals were actively immunized with Shigella. The agglutinins that now appeared in these rabbits gave positive reactions with the fluorescent antibody against their own allotype. These data indicated that in moderately X-irradiated rabbits given antigen-incubated rabbit lymph node cells, the antibody that subsequently appears in the recipient's serum has been synthesized by the donor's cells. These experiments also illustrate the use of allotypes as genetic markers in lymph node cell transfer experiments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GAMMA globulins
KW  - GENETIC markers
KW  - LYMPH nodes
KW  - IMMUNOGLOBULIN allotypes
KW  - IMMUNOGENETICS
KW  - IMMUNOLOGY
N1  - Accession Number: 12673789; Harris, T.N. 1; Dray, Sheldon 1; Ellsworth, Barbara 1; Harris, Susanna 1; Source Information: Mar63, Vol. 6 Issue 2, p169; Subject: GAMMA globulins; Subject: GENETIC markers; Subject: LYMPH nodes; Subject: IMMUNOGLOBULIN allotypes; Subject: IMMUNOGENETICS; Subject: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2013-39667-011
AN  - 2013-39667-011
AU  - Gorwitz, Kurt
AU  - Bahn, Anita K.
AU  - Chandler, Caroline A.
AU  - Martin, William A.
T1  - Planned uses of a statewide psychiatric register for aiding mental health in the community.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1963/04//
VL  - 33
IS  - 3
SP  - 494
EP  - 500
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39667-011. Partial author list: First Author & Affiliation: Gorwitz, Kurt; Maryland State Department of Mental Hygiene, Baltimore, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Public Health Services; Treatment Planning. Minor Descriptor: Hospitals; Psychiatric Clinics. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1963. Publication History: Accepted Date: Oct 18, 1962. 
AB  - The traditional pattern of public psychiatric services of previous years is changing. In place of the mental hospital, isolated in function and separated in program planning from other community services, a comprehensive program is emerging. Psychiatric clinics, general hospitals and other newly developed forms of psychiatric service carry an increasing share of the psychiatric responsibility, and a variety of nonpsychiatric community agencies offers important services to, or on behalf of, the mentally ill. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - statewide psychiatric register
KW  - community mental health services
KW  - public health services
KW  - treatment planning
KW  - general hospitals
KW  - psychiatric clinics
KW  - 1963
KW  - Community Mental Health Services
KW  - Public Health Services
KW  - Treatment Planning
KW  - Hospitals
KW  - Psychiatric Clinics
KW  - 1963
DO  - 10.1111/j.1939-0025.1963.tb00383.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39667-015
AN  - 2013-39667-015
AU  - Stein, Johanna
T1  - Music therapy treatment techniques.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1963/04//
VL  - 33
IS  - 3
SP  - 521
EP  - 528
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39667-015. Partial author list: First Author & Affiliation: Stein, Johanna; Section on Psychiatry, National Institute of Mental Health, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Music Therapy; Psychotherapy; Rehabilitation; Therapeutic Processes. Minor Descriptor: Hospitalized Patients; Psychiatric Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Inpatient (50). Page Count: 8. Issue Publication Date: Apr, 1963. Publication History: Accepted Date: Nov 20, 1962. 
AB  - Work in music was structured so as to intervene in patterns of thought and behavior prohibitive to psychotherapy and rehabilitation of severely disturbed psychiatric inpatients. The course of four patients in music therapy is described to illustrate techniques used and their effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment techniques
KW  - music therapy
KW  - psychotherapy
KW  - rehabilitation
KW  - psychiatric inpatients
KW  - 1963
KW  - Music Therapy
KW  - Psychotherapy
KW  - Rehabilitation
KW  - Therapeutic Processes
KW  - Hospitalized Patients
KW  - Psychiatric Patients
KW  - 1963
U1  - Sponsor: National Institute of Mental Health, US. Recipients: No recipient indicated
DO  - 10.1111/j.1939-0025.1963.tb00387.x
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DB  - psyh
ER  - 

TY  - JOUR
AU  - Birren, James E.
T1  - Research on the psychologic aspects of aging.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1963/05//
VL  - 18
IS  - 5
M3  - Article
SP  - 393
EP  - 403
SN  - 0016867X
N1  - Accession Number: 17145092; Birren, James E. 1; Source Information: May1963, Vol. 18 Issue 5, p393; Number of Pages: 11p; Illustrations: 8 Graphs; Document Type: Article; Full Text Word Count: 3288
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Wilkie, Charlotte H.
T1  - A Study of Distortions in Recording Interviews.
JO  - Social Work
JF  - Social Work
Y1  - 1963/07//
VL  - 8
IS  - 3
M3  - Article
SP  - 31
EP  - 36
SN  - 00378046
AB  - This article explores the nature of the caseworkers' "distortions" in their recording of clients' communications about their problems, attitudes and values. The term distortion is used here in its descriptive sense of change of an original form. The problem of distortions is important because of the struggle to reduce the empirical quality of the worker's every day job and to develop an increasingly scientific basis for it. Recent years have seen many research studies aimed at analyzing the subjective quality of the interviewers perception and observations. The availability of verbatim recording by mechanical means has made this possible and easy. In 1944, Bernard J. Covner, a psychologist, made a study of a number of counseling interviews to analyze the accuracy of the written report as against the phonographic recording. This study was again repeated in 1958 by sociologist C.P. Froelich and yielded very much the same results. In general, a large part of client's interview is not recorded but what is recorded is accurate. According to the study, distortions in communication with clients because of lack of familiarity with deeply pathological patterns of behavior are easier to control as new knowledge of these patterns is acquired. It would be helpful to become aware of those unconscious omissions early in contacts, as they are in the service of workers needs other than the client's.
KW  - Interviewing
KW  - Counseling
KW  - Sound recording & reproducing
KW  - Communication
KW  - Attitude (Psychology)
KW  - Quality
KW  - Empirical research
N1  - Accession Number: 14204596; Wilkie, Charlotte H. 1; Affiliations: 1: Social worker with the Social Service Department, National Institute of Mental Health, Public Health Service,; Issue Info: Jul63, Vol. 8 Issue 3, p31; Thesaurus Term: Interviewing; Thesaurus Term: Counseling; Thesaurus Term: Sound recording & reproducing; Thesaurus Term: Communication; Thesaurus Term: Attitude (Psychology); Subject Term: Quality; Subject Term: Empirical research; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 512240 Sound Recording Studios; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 2013-39333-008
AN  - 2013-39333-008
AU  - Murphey, Elizabeth B.
AU  - Silber, Earle
AU  - Coelho, George V.
AU  - Hamburg, David A.
AU  - Greenberg, Irwin
T1  - Development of autonomy and parent-child interaction in late adolescence.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1963/07//
VL  - 33
IS  - 4
SP  - 643
EP  - 652
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39333-008. Partial author list: First Author & Affiliation: Murphey, Elizabeth B.; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: College Students; Family; Parent Child Relations. Minor Descriptor: Adolescent Development; Autonomy. Classification: Childrearing & Child Care (2956). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1963. Publication History: Accepted Date: Jan 17, 1962. 
AB  - This study explores the relationship between the capacity for autonomous behavior among freshman college students and the patterns of interaction between the students and their parents during the transition from high school to college. Autonomous-relatedness, the capacity for integration of both independent behavior and the maintenance of positive family ties, appears related to particular transactional family patterns, which were observed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - autonomous behavior
KW  - freshman college students
KW  - parent-child interaction
KW  - transactional family patterns
KW  - independent behavior
KW  - 1963
KW  - College Students
KW  - Family
KW  - Parent Child Relations
KW  - Adolescent Development
KW  - Autonomy
KW  - 1963
DO  - 10.1111/j.1939-0025.1963.tb01012.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39333-008&site=ehost-live&scope=site
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DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39333-012
AN  - 2013-39333-012
AU  - Rioch, Margaret J.
AU  - Elkes, Charmian
AU  - Flint, Arden A.
AU  - Usdansky, Blanche Sweet
AU  - Newman, Ruth G.
AU  - Silber, Earle
T1  - National Institute of Mental Health pilot study in training mental health counselors.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1963/07//
VL  - 33
IS  - 4
SP  - 678
EP  - 689
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Rioch, Margaret J., Adult Psychiatry Branch, National Institute of Mental Health, 14, Bethesda, MD, US
N1  - Accession Number: 2013-39333-012. Partial author list: First Author & Affiliation: Rioch, Margaret J.; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counselors; Mental Health; Mental Health Personnel; Psychotherapy. Classification: Professional Education & Training (3410). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Interview; Quantitative Study. Page Count: 12. Issue Publication Date: Jul, 1963. Publication History: Accepted Date: Feb 8, 1963. 
AB  - The paper describes the first year's work in an experiment to test the hypothesis that carefully selected mature people can be trained within two years to do psychotherapy under limited conditions. Eight 40-year-old married women with children were trained in a very practical program. The results were positive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health counselors
KW  - psychotherapy
KW  - counselor training
KW  - 1963
KW  - Counselors
KW  - Mental Health
KW  - Mental Health Personnel
KW  - Psychotherapy
KW  - 1963
DO  - 10.1111/j.1939-0025.1963.tb01016.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39333-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06049-016
AN  - 2006-06049-016
AU  - Bergman, Paul
T1  - The Liberals in Psychoanalysis.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1963/08//
VL  - 8
IS  - 8
SP  - 309
EP  - 310
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06049-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychoanalysis; Psychoanalytic Theory; Psychoanalytic Training; Social Sciences. Minor Descriptor: Achievement. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Masserman, Jules H. (Ed). Science and Psychoanalysis. Vol. V: Psychoanalytic Education=New York: Grune & Stratton, 1962. Pp. v + 332. $9.75; 1962. Page Count: 2. Issue Publication Date: Aug, 1963. 
AB  - Reviews the book, Science and Psychoanalysis. Vol. V: Psychoanalytic Education edited by Jules H. Masserman (1962). The book contains pleas for biology; social sciences; psychosomatics; communciation processes; flexible therapeutic methods; ward psychiatry; identity problems; value problems; research; alternative theoretical models. The writers present their cases capably, informatively and even convincingly insofar as one cannot reasonably doubt the relevance of these various concerns to the subject matter of psychoanalysis. None of the writers, however, shows how all this material could be integrated into a professional training without intolerably overloading it. Psychoanalytic theory has its own tasks and problems with which the 'liberals' frequently show insufficient acquaintance. They particularly neglect the achievements of ego psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychoanalysis
KW  - psychoanalytic education
KW  - psychoanalytic theory
KW  - professional training
KW  - ego psychology
KW  - 1963
KW  - Psychoanalysis
KW  - Psychoanalytic Theory
KW  - Psychoanalytic Training
KW  - Social Sciences
KW  - Achievement
KW  - 1963
U2  - Masserman, Jules H. (Ed). (1962); Science and Psychoanalysis. Vol. V: Psychoanalytic Education; New York: Grune & Stratton, 1962. Pp. v + 332. $9.75
DO  - 10.1037/007306
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06049-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06049-017
AN  - 2006-06049-017
AU  - Bergman, Paul
T1  - First Freudians.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1963/08//
VL  - 8
IS  - 8
SP  - 310
EP  - 311
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06049-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Freud (Sigmund); Psychoanalysis; Psychoanalytic Theory; Society. Minor Descriptor: Evaluation. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Nunberg, Herman (Ed); Federn, Ernst (Ed); Nunberg, M. (Ed). Minutes of the Vienna Psychoanalytic Society, Vol. 1: 1906-1908=New York: International Universities Press, 1962. Pp. v + 410. $10.00; 1962. Page Count: 2. Issue Publication Date: Aug, 1963. 
AB  - Reviews the book, Minutes of the Vienna Psychoanalytic Society, Vol. 1: 1906-1908 by Herman Nunberg, Ernst Federn and M. Nunberg (1962). The present volume shows the 'professor' presiding in Olympian benevolence, often protecting speakers from too violent attacks, and distinctly favoring those who contributed creatively to the ideas of the circle. Freud's social evaluation of sexuality retains its previous puzzling ambiguity. Whether or not Freud and his followers at times succumbed to self-contradiction, bias and passion, these pages do preserve some great moments in the history of man's spirit. The editors deserve thanks for publishing these minutes and for conscientiously clarifying in footnotes a great many allusions to persons and events which otherwise would remain meaningless. unfortunately they have also added footnotes to expound their own opinions about many of the subjects under discussion, and to stand up for Freud against any doubting or dissenting voice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychoanalytic society
KW  - self contradiction
KW  - Freuds social evaluation
KW  - psychoanalysis
KW  - 1963
KW  - Freud (Sigmund)
KW  - Psychoanalysis
KW  - Psychoanalytic Theory
KW  - Society
KW  - Evaluation
KW  - 1963
U2  - Nunberg, Herman (Ed); Federn, Ernst (Ed); Nunberg, M. (Ed). (1962); Minutes of the Vienna Psychoanalytic Society, Vol. 1: 1906-1908; New York: International Universities Press, 1962. Pp. v + 410. $10.00
DO  - 10.1037/007307
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06050-032
AN  - 2006-06050-032
AU  - Korchin, Sheldon J.
T1  - More on Zigler on Witkin.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1963/09//
VL  - 8
IS  - 9
SP  - 365
EP  - 366
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06050-032. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Korchin, Sheldon J.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Piaget (Jean); Psychological Development. Classification: Developmental Psychology (2800). Population: Human (10). Page Count: 2. Issue Publication Date: Sep, 1963. 
AB  - Comments on Zigler's review (see record [rid]2006-06045-004[/rid]) of Witkin et al 's book Psychological Differentiation: Studies of Development (see record [rid]1963-00819-000[/rid]). The review gives a limited and distorted, as well as generally unsympathetic, picture of the purposes, methods, findings and theoretical position of what is a major contribution of a vigorous and dedicated research group. The reviewer is critical of the authors' theoretical effort ('which promises so much and delivers so little') but nowhere is the differentiation hypothesis described, nor is there mention of the supplementary constructs--the sense of separate identity, defined body concepts, specialized defenses, etc.--important to the understanding of reviewer's view. The judgment that differentiation reduces to decontextualization in reviewer's usage, and that this brings it into conflict with the work of Werner and Piaget, is unjustified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological differentiation
KW  - psychological development
KW  - 1963
KW  - Piaget (Jean)
KW  - Psychological Development
KW  - 1963
DO  - 10.1037/007346
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - 
AU  - Bower, Eli M.1
T1  - Mental Health and Education: A Play in Three Acts.
JO  - Educational Leadership
JF  - Educational Leadership
J1  - Educational Leadership
PY  - 1963/10//
Y1  - 1963/10//
VL  - 21
IS  - 1
CP  - 1
M3  - Article
SP  - 8
EP  - 63
SN  - 00131784
AB  - The article discusses developments of the education and mental health in the 20th century. The first State Mental Health Association was started in Connecticut in 1908. A series of meetings to plan a child guidance clinic for juvenile offenders was held in Chicago by Dr. William Healy. In 1908, Dr. Henry Goddard at the Vineland school in New Jersey started to use a new mechanical scale to assess the mental age of children. The scale was devised by Drs. Binet and Simon. In the same year the number of clinics, family service agencies, welfare departments and other community agencies increased. In 1920 a five year program for the prevention of juvenile delinquency was launched with the help of the Commonwealth Fund and the National Committee for Mental Hygiene. Meanwhile health personnel renew their strategy of help to cure the problem of juvenile delinquents.
KW  - Education
KW  - Child mental health services
KW  - Juvenile delinquents -- Health
KW  - Problem children
KW  - Health facilities
KW  - Educational counseling
KW  - Mental age
KW  - Mental health
KW  - Physicians
N1  - Accession Number: 21641394; Authors: Bower, Eli M. 1; Affiliations:  1: Consultant, Mental Health in Education, National Institute of Mental Health, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland.; Subject: Child mental health services; Subject: Education; Subject: Juvenile delinquents -- Health; Subject: Problem children; Subject: Health facilities; Subject: Educational counseling; Subject: Mental age; Subject: Mental health; Subject: Physicians; Number of Pages: 4p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
ID  - 2013-39342-003
AN  - 2013-39342-003
AU  - Forstenzer, Hyman M.
AU  - Felix, Robert H.
T1  - Community mental health—1963 symposium: 1. Community mental health.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1963/10//
VL  - 33
IS  - 5
SP  - 788
EP  - 795
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39342-003. Partial author list: First Author & Affiliation: Forstenzer, Hyman M.; New York State Department of Mental Hygiene, Albany, NY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health; Knowledge (General); Interpersonal Control. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 8. Issue Publication Date: Oct, 1963. Publication History: Accepted Date: Jul 5, 1963. 
AB  - Success of the National Mental Health Program proposed by President Kennedy hinges on public acceptance of the comprehensive Community Mental Health Center concept of care for the mentally ill; on coordinated and adequate planning; on proper recruitment and utilization of manpower; and on an expanded and intensified search for new knowledge and techniques. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health
KW  - public acceptance
KW  - manpower
KW  - knowledge
KW  - 1963
KW  - Community Mental Health
KW  - Knowledge (General)
KW  - Interpersonal Control
KW  - 1963
DO  - 10.1111/j.1939-0025.1963.tb01040.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39342-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39342-009
AN  - 2013-39342-009
AU  - Bower, Eli M.
T1  - Primary prevention of mental and emotional disorders: A conceptual framework and action possibilities.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1963/10//
VL  - 33
IS  - 5
SP  - 832
EP  - 848
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Bower, Eli M., Research Utilization Branch, National Institute of Mental Health, 14, Bethesda, MD, US
N1  - Accession Number: 2013-39342-009. Partial author list: First Author & Affiliation: Bower, Eli M.; Research Utilization Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Disturbances. Minor Descriptor: Concept Formation; Primary Mental Health Prevention; Psychologists. Classification: Psychological & Physical Disorders (3200). Population: Human (10). References Available: Y. Page Count: 17. Issue Publication Date: Oct, 1963. Publication History: Accepted Date: Jun 6, 1961. 
AB  - Prevention is seen as a magic word that has had little action implementation in the field of mental and emotional disorders. Moreover, lay and professional groups appear to have a desultory defeatist attitude toward such activity. In part, this is the result of an inability to conceptualize a usable and meaningful theoretical structure from which research and demonstration programs can be developed. A conceptualization of primary prevention and programs of research and demonstration are presented and discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - conceptual framework
KW  - emotional disorders
KW  - primary prevention
KW  - professional groups
KW  - 1963
KW  - Emotional Disturbances
KW  - Concept Formation
KW  - Primary Mental Health Prevention
KW  - Psychologists
KW  - 1963
DO  - 10.1111/j.1939-0025.1963.tb01046.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2007-11837-002
AN  - 2007-11837-002
AU  - Basowitz, Harold
AU  - Speisman, Joseph C.
ED  - Blank, Leonard
ED  - David, Henry P.
ED  - Blank, Leonard, (Ed)
ED  - David, Henry P., (Ed)
T1  - Program support for training by the National Institute of Mental Health: 1947-1963.
T2  - Sourcebook for training in clinical psychology.
Y1  - 1964///
SP  - 43
EP  - 60
CY  - New York, NY, US
PB  - Springer Publishing Co
N1  - Accession Number: 2007-11837-002. Partial author list: First Author & Affiliation: Basowitz, Harold; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20070806. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Experimentation; Mental Health; Mental Health Programs; Psychology; Training. Minor Descriptor: Funding; Personnel Supply; Public Health. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 18. 
AB  - The National Institute of Mental Health (NIMH) is one of nine organizational units which in the aggregate comprise the National Institutes of Health and serve as the principal research arm of the United States Public Health Service (USPHS). The NIMH was established as a consequence of Congressional action in 1946. Its mandate is to improve the mental health of the nation. Four basic functions are involved: 1) the conduct of research into the etiology, diagnosis, treatment and prevention of mental illness; 2) assistance and support of such research activities by universities, medical schools and other public and private agencies; 3) consultation, technical services and grants to states and communities to aid in the development of comprehensive mental health programs; and 4) support of mental health manpower training for research and service. The present chapter deals with the last of these four functions--training--as it bears particularly upon the field of psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - comprehensive mental health programs
KW  - program support
KW  - research
KW  - consultation
KW  - technical services
KW  - grants
KW  - mental health manpower
KW  - mental health training
KW  - psychology
KW  - 1964
KW  - Experimentation
KW  - Mental Health
KW  - Mental Health Programs
KW  - Psychology
KW  - Training
KW  - Funding
KW  - Personnel Supply
KW  - Public Health
KW  - 1964
DO  - 10.1037/11535-002
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-17083-002
AN  - 2011-17083-002
AU  - Bower, Eli M.
T1  - Psychology in the schools: Conceptions, processes and territories.
JF  - Psychology in the Schools
JO  - Psychology in the Schools
JA  - Psychol Sch
Y1  - 1964/01//
VL  - 1
IS  - 1
SP  - 3
EP  - 11
CY  - US
PB  - John Wiley & Sons
SN  - 0033-3085
SN  - 1520-6807
N1  - Accession Number: 2011-17083-002. Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, United Kingdom. Release Date: 20120312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Education; Psychologists; Schools. Classification: Educational Psychology (3500). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 9. Issue Publication Date: Jan, 1964. 
AB  - In order to make human beings out of potential human beings, human societies have created institutions such as families and schools. The nature and specific processes by which these institutions carry out their purposes vary with the kind of human qualities espoused in each society. The purpose of this issue in our society is to produce emotionally free, cognitively effective human beings. As psychologists are concerned with the impact of cognitive-affective experiences in producing this kind of human being; as professional practitioners, psychologists are concerned with contributing their knowledge and skills to educators so that relevant behavioral science knowledge and experience can be transmitted and utilized by the educational institutions and their staffs. There is an inexcusable snobbery about educational processes which reflects a lack of conviction about the psychological and transactional properties of learning. The fact that differences between and among people necessitate qualitative differences in educational content and process does not mean such differences must have lesser or greater value or significance as a human experience. Psychologists and educators need to promote differences among and between educational experiences while at the same time enhancing the value of each as a meaningful transaction to the child and to society. It was suggested earlier that going to school was for children and adolescents what going to work was for adults. The greatest stumbling block however for educators and psychologists lies in the perception of their own job. Professional competency and leadership lie not so much in doing one’s job well but in understanding the primary purpose of what one is doing and its place in the scheme of things. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychologists
KW  - cognitive experiences
KW  - educational content
KW  - schools
KW  - 1964
KW  - Cognitive Processes
KW  - Education
KW  - Psychologists
KW  - Schools
KW  - 1964
DO  - 10.1002/1520-6807(196401)1:1<3::AID-PITS2310010102>3.0.CO;2-P
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Ball, John C.
AU  - Ross, Alan
AU  - Simpson, Alice
T1  - INCIDENCE AND ESTIMATED PREVALENCE OF RECORDED DELINQUENCY IN A METROPOLITAN AREA.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1964/02//
VL  - 29
IS  - 1
M3  - Article
SP  - 90
EP  - 93
SN  - 00031224
AB  - Juvenile court data from Fayette County, Kentucky, a metropolitan area, were used to compute the incidence and prevalent rates of delinquency for 1960. The incidence varies markedly with age and sex, the highest being among 17-year-old boys. The outcome of the study is a new procedure for estimating the prevalence of delinquency in a given population. 7 notes, 2 tables.
KW  - JUVENILE delinquency
KW  - CONDUCT disorders in children
KW  - JUVENILE courts
KW  - LARCENY
KW  - CRIMINAL courts
KW  - FAYETTE County (Ky.)
KW  - KENTUCKY
KW  - UNITED States
KW  - Kentucky (Fayette County)
N1  - Accession Number: 12766726; Ball, John C. 1; Ross, Alan 2; Simpson, Alice 2; Affiliations: 1 : National Institute of Mental Health Lexington, Kentucky.; 2 : University of Kentucky.;  Source Info: Feb64, Vol. 29 Issue 1, p90; Historical Period: 1960; Subject Term: JUVENILE delinquency; Subject Term: CONDUCT disorders in children; Subject Term: JUVENILE courts; Subject Term: LARCENY; Subject Term: CRIMINAL courts; Subject: FAYETTE County (Ky.); Subject: KENTUCKY; Subject: UNITED States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Ruhl, Mary Jane
T1  - Chemical Documents and their Titles: Human Concept Indexing vs. KWlC-Machine Indexing.
JO  - American Documentation
JF  - American Documentation
Y1  - 1964/04//
VL  - 15
IS  - 2
M3  - Article
SP  - 136
EP  - 141
SN  - 0096946X
AB  - The machine-produced, key-word-in-context title index was introduced as a temporary bridge between current literature and its indexes. Due to the lower cost and more rapid production, some researchers might substitute these indexes for the conventional ones, but valuable research findings might be lost if titles omit important descriptive words. Comparing the indexing of the same documents in Chemical Titles and Chemical Abstracts Subject Index shows that more than half of the titles included all concepts, or their equivalents, as indexed by Chemical Abstracts. However, in many cases, more definitive titles might have been assigned to the documents. Authors and editors must continue to upgrade their titles by examining each title word. Does each word define some aspect of the report? Have words been included in the title to describe, as nearly as possible, each important new development reported? [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Documentation is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INDEXES
KW  - DOCUMENTATION
KW  - LITERATURE
KW  - ABSTRACTS
KW  - DESCRIPTIVE cataloging
KW  - INDEXING
N1  - Accession Number: 16778390; Ruhl, Mary Jane 1,2; Affiliations: 1: Biological Sciences Communication Project, George Washington University, Washington 6, D. C.; 2: American Rheumatism Association, Literature Analysis Project,  National Institutes of Health, Bethesda, Maryland.; Issue Info: Apr1964, Vol. 15 Issue 2, p136; Thesaurus Term: INDEXES; Thesaurus Term: DOCUMENTATION; Subject Term: LITERATURE; Subject Term: ABSTRACTS; Subject Term: DESCRIPTIVE cataloging; Subject Term: INDEXING; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Erlich, Howard J.
T1  - These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations.
JO  - Sociological Quarterly
JF  - Sociological Quarterly
Y1  - 1964///Spring64
VL  - 5
IS  - 2
M3  - Book Review
SP  - 177
EP  - 178
SN  - 00380253
AB  - Reviews the book "These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations," by Jacqueline J. Clarke.
KW  - CIVIL rights organizations
KW  - NONFICTION
KW  - CLARKE, Jacqueline J.
KW  - THESE Rights They Seek (Book)
N1  - Accession Number: 14021169; Erlich, Howard J. 1; Affiliations: 1 : National Institute of Mental Health;  Source Info: Spring64, Vol. 5 Issue 2, p177; Subject Term: CIVIL rights organizations; Subject Term: NONFICTION; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - 24h
ER  - 

TY  - JOUR
ID  - 2011-17084-008
AN  - 2011-17084-008
AU  - Gladwin, Thomas
T1  - The school, society, and the child.
JF  - Psychology in the Schools
JO  - Psychology in the Schools
JA  - Psychol Sch
Y1  - 1964/04//
VL  - 1
IS  - 2
SP  - 162
EP  - 173
CY  - US
PB  - John Wiley & Sons
SN  - 0033-3085
SN  - 1520-6807
N1  - Accession Number: 2011-17084-008. Partial author list: First Author & Affiliation: Gladwin, Thomas; National Institute of Mental Health, US. Release Date: 20120312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Childhood Development; Education; Schools; Society. Classification: Educational Psychology (3500). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 12. Issue Publication Date: Apr, 1964. 
AB  - The school is obviously a part of our total culture. It is not only caught in the conflicts of the larger society, but also necessarily itself contributes to the inconsistencies with which the child is faced. The child is expected to develop confidence and self-assurance. The pressures we exert are not only strong but are also frequently so contradictory that the child cannot by himself resolve them. The fact that school contributes to these conflicts and pressures is certainly not new to educators. Some of the more radical attempts to counter or eliminate pressures on children have illustrated the difficulties involved. The educational system is an instrument of the larger society. The social skills and perceptiveness of a child also change markedly as he grows up. A wide variety of factors could be considered with respect to the continuity between in-school and out-of-school experience. The ability of teachers to react immediately and perceptively to subtle emotional responses in their students has an important bearing on the number of students with whom they can develop a constructive social relationship. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schools
KW  - societies
KW  - childhood development
KW  - education
KW  - 1964
KW  - Childhood Development
KW  - Education
KW  - Schools
KW  - Society
KW  - 1964
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06058-020
AN  - 2006-06058-020
AU  - Bergman, Paul
T1  - 'And a time to laugh.'
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1964/05//
VL  - 9
IS  - 5
SP  - 219
EP  - 220
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06058-020. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Jokes; Laughter; Psychoanalysis; Unconscious (Personality Factor). Minor Descriptor: Hate Crimes. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Freud, Sigmund; Strachey, James (Ed). Jokes and their Relation to the Unconscious=New York: W. W. Norton & Co., 1963. Pp. 258. $1.45; 1963. Page Count: 2. Issue Publication Date: May, 1964. 
AB  - Reviews the book, Jokes and their Relation to the Unconscious by Sigmund Freud (edited and translated by James Strachey) (see record [rid]1964-02765-000[/rid]). Freud wrote the present book in 1905, but the new translation, done by Strachey for the Standard Edition of the Complete Works, reveals for the first time in English the charm of the work, unencumbered by the clumsiness of the earlier version. Here one can see Freud's superb patience in focusing on detail and his amazing power of organization as he places detail in the context of his view of man. Freud's own greatness repeatedly manifests itself; also that at times it is hard to decide whether or not an expression of his basic attitude is intentional. Jokes are a simple, objectively available material not embedded in a complex living organism. A dubious beginning, a stupendous second phase, an abortive ending, this is the conception of the typical course of Freud's thought. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - jokes
KW  - unconscious
KW  - laugh
KW  - 1964
KW  - Jokes
KW  - Laughter
KW  - Psychoanalysis
KW  - Unconscious (Personality Factor)
KW  - Hate Crimes
KW  - 1964
U2  - Freud, Sigmund; Strachey, James (Ed). (1963); Jokes and their Relation to the Unconscious; New York: W. W. Norton & Co., 1963. Pp. 258. $1.45
DO  - 10.1037/007558
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06058-020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Duhl, Leonard J.
T1  - A Mental Health Program for the Peace Corps.
JO  - Human Organization
JF  - Human Organization
Y1  - 1964///Summer64
VL  - 23
IS  - 2
M3  - Article
SP  - 131
EP  - 136
SN  - 00187259
AB  - Describes the mental health program of the Peace Corps; its role in the selection of volunteers, assistance to volunteers during their tour of duty, and its assistance on reentry into American culture. 11 notes.
KW  - MENTAL health facilities
KW  - PSYCHOLOGISTS
KW  - COMMUNITY mental health services
KW  - HEALTH promotion
KW  - SOCIAL systems
KW  - MEDICAL corporations
KW  - MENTAL health services
KW  - MENTAL health
KW  - UNITED States
KW  - PEACE Corps (U.S.)
N1  - Accession Number: 26909689; Duhl, Leonard J. 1,2,3; Affiliations: 1 : Psychiatrist, Professional Services Branch, National Institute of Mental Health, George Washington University, Washington, D.C.; 2 : NIMH-Peace Corps Liaison Representative and Consultant in Psychiatry, George Washington University, Washington, D.C.; 3 : Clinical Assistant Professor in Psychiatry, George Washington University, Washington, D.C.;  Source Info: Summer64, Vol. 23 Issue 2, p131; Historical Period: 1962; Subject Term: MENTAL health facilities; Subject Term: PSYCHOLOGISTS; Subject Term: COMMUNITY mental health services; Subject Term: HEALTH promotion; Subject Term: SOCIAL systems; Subject Term: MEDICAL corporations; Subject Term: MENTAL health services; Subject Term: MENTAL health; Subject: UNITED States; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
ID  - 2006-06059-014
AN  - 2006-06059-014
AU  - Rheingold, Harriet L.
T1  - Descriptively psychiatric.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1964/06//
VL  - 9
IS  - 6
SP  - 261
EP  - 262
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06059-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rheingold, Harriet L.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childrearing Practices; Developmental Psychology; Infant Development; Institutionalization; Psychometrics. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Provence, Sally; Lipton, Rose C. Infants in Institutions: A Comparison of Their Development with Family-Reared Infants During the First Year of Life=New York: International Universities Press, 1962. Pp. v + 191. $5.00; 1962. Page Count: 2. Issue Publication Date: Jun, 1964. 
AB  - Reviews the book, Infants in Institutions: A Comparison of Their Development with Family-Reared Infants During the First Year of Life by Sally Provence and Rose C. Lipton (see record [rid]1963-07862-000[/rid]). This study finds that infants in an institution do more poorly, by the criteria of comparison chosen, than an equal number of home babies. The infants were given psychological tests; although the authors refer to the tests in making their judgments, they do not present the results since their data, 'interpreted statistically, do not reveal new findings.' Little is revealed about the selection of the infants. Infants in instiutions do not really provide one of Nature's experiments because differences observed between groups of home and institutionalized infants cannot be interpreted as caused solely by the differences in the environment. This book's contribution lies in its carefully detailed account of infant behavior and environment. Certainly no one will quarrel with the authors' plea for improving infant care in poor institutions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological tests
KW  - institutionalized infants
KW  - infant behavior
KW  - family reared infants
KW  - nfant development
KW  - 1964
KW  - Childrearing Practices
KW  - Developmental Psychology
KW  - Infant Development
KW  - Institutionalization
KW  - Psychometrics
KW  - 1964
U2  - Provence, Sally; Lipton, Rose C. (1962); Infants in Institutions: A Comparison of Their Development with Family-Reared Infants During the First Year of Life; New York: International Universities Press, 1962. Pp. v + 191. $5.00
DO  - 10.1037/007588
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Legler, Jean F.
AU  - Benchimol, Alberto
T1  - The significance of extrasystoles in coronary artery disease.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1964/07//
VL  - 19
IS  - 7
M3  - Article
SP  - 468
EP  - 475
SN  - 0016867X
N1  - Accession Number: 17107674; Legler, Jean F. 1; Benchimol, Alberto 2; Source Information: Jul1964, Vol. 19 Issue 7, p468; Number of Pages: 8p; Illustrations: 8 Diagrams; Document Type: Article; Full Text Word Count: 2547
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2011-17085-008
AN  - 2011-17085-008
AU  - Duhl, Leonard J.
T1  - Crises, adaptive potential and the school.
JF  - Psychology in the Schools
JO  - Psychology in the Schools
JA  - Psychol Sch
Y1  - 1964/07//
VL  - 1
IS  - 3
SP  - 263
EP  - 266
CY  - US
PB  - John Wiley & Sons
SN  - 0033-3085
SN  - 1520-6807
N1  - Accession Number: 2011-17085-008. Partial author list: First Author & Affiliation: Duhl, Leonard J.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20120326. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Attention; Childhood Development; Crises. Minor Descriptor: Schools. Classification: Cognitive & Perceptual Development (2820). Population: Human (10). Page Count: 4. Issue Publication Date: Jul, 1964. 
AB  - If one is concerned with the normal development of children, one cannot help but focus attention on the school. The school claims the time, attention and concerns of the child for a major period of the child’s life. There have been many ways of looking at the school and its impact on children. This article concentrates on one approach rather than review all the studies in this field dealing with this experience. This concentration results from the belief that this approach arising from the work in preventive community mental health may be equally relevant to the field of education. There has been no attempt in this paper to present a comprehensive model of the school or of human development. It is hoped that the concepts so briefly outlined above can be understood more fully. There have been some school programs that have been indeed using this model effectively in understanding themselves. The schools in fact are in crises, and the choice of responses to these crises can lead both to danger and to opportunity for child, school and society. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - childhood development
KW  - crises
KW  - attention
KW  - school
KW  - 1964
KW  - Attention
KW  - Childhood Development
KW  - Crises
KW  - Schools
KW  - 1964
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06060-006
AN  - 2006-06060-006
AU  - Blank, Paul
T1  - On states and acts.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1964/07//
VL  - 9
IS  - 7
SP  - 281
EP  - 282
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06060-006. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Blank, Paul; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Nature; Love; Motivation; Needs. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Reik, Theodor. The Need to be Loved=New York: Farrar, Straus and Co., 1963. Pp. 276. $4.95; 1963. Page Count: 2. Issue Publication Date: Jul, 1964. 
AB  - Reviews the book, The Need to be Loved by Theodor Reik (1963). Through most of Reik's commentaries run the hopes, fantasies, sorrows, illusions and paradoxes of human nature; a spectacle with large reflections about behavior as viewed through a prism constructed out of crystal clear drives and instincts. It would take many evenings indeed to recount the book's three hundred and twenty-three commentaries whose topics, numbered and titled, range far and wide and whose relevance to the subject of the book is not immediately apparent. Instead, too many sayings in the book are contrived and banal, substituting literary platitudes for profundities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - needs
KW  - loved
KW  - drives
KW  - instincts
KW  - 1964
KW  - Human Nature
KW  - Love
KW  - Motivation
KW  - Needs
KW  - 1964
U2  - Reik, Theodor. (1963); The Need to be Loved; New York: Farrar, Straus and Co., 1963. Pp. 276. $4.95
DO  - 10.1037/007605
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06060-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06060-009
AN  - 2006-06060-009
AU  - Bower, Eli M.
T1  - Growing pains.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1964/07//
VL  - 9
IS  - 7
SP  - 284
EP  - 285
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06060-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Curriculum; Professional Development; School Psychology; Teaching. Classification: Educational Psychology (3500). Population: Human (10). Reviewed Item: Gottsegen, Monroe G. (Ed); Gottsegen, Gloria B. (Ed). Professional School Psychology. Vol. II=New York: Grune and Stratton, 1963. Pp. iii + 354. $9.75; 1963. Page Count: 2. Issue Publication Date: Jul, 1964. 
AB  - Reviews the book, Professional School Psychology. Vol. II edited by Monroe G. Gottsegen and Gloria B. Gottsegen (see record [rid]1964-04646-000[/rid]). The Gottsegens have made a start in getting a number of knowledgeable and imaginative 'parents' to identify the specific areas in the infant where growth and development are taking place. Each of the contributors presents his material clearly and concisely with only occasional lapses into dullness and discussion of the obvious. Several contributors are concerned with psychotherapy in school and graciously minimize the hoary debate on whether this function is relevant for this profession. The teaching of psychology is brought into the picture as well as research in curriculum. All in all one gets a savory and tasty spread of topics but I'm afraid the nature of the menu still remains largely in the eye of the beholder. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - professional school psychology
KW  - curriculum
KW  - teaching
KW  - developmental psychology
KW  - 1964
KW  - Curriculum
KW  - Professional Development
KW  - School Psychology
KW  - Teaching
KW  - 1964
U2  - Gottsegen, Monroe G. (Ed); Gottsegen, Gloria B. (Ed). (1963); Professional School Psychology. Vol. II; New York: Grune and Stratton, 1963. Pp. iii + 354. $9.75
DO  - 10.1037/007608
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06060-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40691-009
AN  - 2013-40691-009
AU  - Bower, Eli M.
T1  - The modification, mediation and utilization of stress during the school years.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1964/07//
VL  - 34
IS  - 4
SP  - 667
EP  - 674
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40691-009. Partial author list: First Author & Affiliation: Bower, Eli M.; Research Utilization Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Modification; Classrooms. Minor Descriptor: Crises; Mediation; School Environment; Stress; Students. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1964. Publication History: Accepted Date: Jan 2, 1964. 
AB  - A n analysis of peaks of normal crises that can be anticipated for school-age children, and some possibilities for managing these crises so that the child becomes a more effective learner, are presented. By establishing barriers at strategic and visible points of crisis (school entrance, birth of sibling, third grade), schools can assist children to build stress immunity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - behavior modification
KW  - mediation
KW  - utilization
KW  - stress
KW  - school years
KW  - 1964
KW  - Behavior Modification
KW  - Classrooms
KW  - Crises
KW  - Mediation
KW  - School Environment
KW  - Stress
KW  - Students
KW  - 1964
DO  - 10.1111/j.1939-0025.1964.tb02367.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40691-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06061-006
AN  - 2006-06061-006
AU  - Tiedeman, David V.
T1  - A potpourri of talent and schools.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1964/08//
VL  - 9
IS  - 8
SP  - 312
EP  - 313
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06061-006. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tiedeman, David V.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Ability; Gifted; High School Education; Secondary Education. Classification: Gifted & Talented (3575). Population: Human (10). Reviewed Item: Flanagan, John C.; Dailey, John T.; Shaycoft, Marion F.; Orr, David B.; Goldberg, Isadore. Project Talent: A Survey and Follow-up Study of Educational Plans and Decisions in Relation to Aptitude Patterns: Studies of the American High School=Pittsburgh, Pa.: University of Pittsburgh, 1962; 1962. Page Count: 2. Issue Publication Date: Aug, 1964. 
AB  - Reviews the book, Project Talent: A Survey and Follow-up Study of Educational Plans and Decisions in Relation to Aptitude Patterns: Studies of the American High School by John C. Flanagan, John T. Dailey, Marion F. Shaycoft, David B. Orr, and Isadore Goldberg (1962). The report deals primarily with the organization and setting of secondary education in some relation to the aptitude and achievement of the pupils. The first general issue is the adoption of a taxonomy of a few classes which effectively carries the evident heterogeneity among the statistical series under study. The second general issue is the effect of community and school organization upon the achievement of pupils. The reviewer believes that this volume is neither a census nor an integrated report of the investigation of adequately circumscribed problems. The reviewer believes that the authors can make more lasting contributions in future reports of Project Talent by publishing a census before they engage alone in research on census-like data which are of such import both to the public and to those who make their livelihood in education. Whatever the cause of seeming ambiguity, it should be understood that, despite difficulty, the present report provides aspects of a benchmark deserving of wide reference. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - talents
KW  - secondary education
KW  - educational plans
KW  - aptitude patterns
KW  - American high school
KW  - 1964
KW  - Ability
KW  - Gifted
KW  - High School Education
KW  - Secondary Education
KW  - 1964
U2  - Flanagan, John C.; Dailey, John T.; Shaycoft, Marion F.; Orr, David B.; Goldberg, Isadore. (1962); Project Talent: A Survey and Follow-up Study of Educational Plans and Decisions in Relation to Aptitude Patterns: Studies of the American High School; Pittsburgh, Pa.: University of Pittsburgh, 1962
DO  - 10.1037/007629
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06061-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-10157-001
AN  - 2005-10157-001
AU  - Schneider, Stanley F.
T1  - Some comments on 'Congenital insensitivity to pain: A critique.'
JF  - Psychological Bulletin
JO  - Psychological Bulletin
JA  - Psychol Bull
Y1  - 1964/10//
VL  - 62
IS  - 4
SP  - 287
EP  - 288
CY  - US
PB  - American Psychological Association
SN  - 0033-2909
SN  - 1939-1455
N1  - Accession Number: 2005-10157-001. Partial author list: First Author & Affiliation: Schneider, Stanley F.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Congenital Disorders; Pain; Pain Perception. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 1964. Copyright Statement: American Psychological Association. 1964. 
AB  - A note on the paper by R. A. Sternbach (see record [rid]1963-07503-001[/rid]) to correct the statement attributed to this author (S. F. Schneider) that the latter considers the syndrome of indifference to pain a defense mechanism, which, in fact, was not the case. A distinction is made between syndrome and defense. A summary of the neuropathologic findings on one of Schneider's cases is presented. Since these findings were equivocal in pathologic significance and thus inconclusive, an explanation of the anomaly on the basis of neural deficit remains as hypothetical as those based upon psychological factors. Sternbach's concluding generalization that pain is not a necessary component in normal personality development is felt to be premature, since the evidence is hardly adequate at this time to describe how the absence of pain may effect personality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - pain
KW  - congenital insensitivity
KW  - 1964
KW  - Congenital Disorders
KW  - Pain
KW  - Pain Perception
KW  - 1964
DO  - 10.1037/h0038461
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10157-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39344-005
AN  - 2013-39344-005
AU  - Brown, Bertram S.
AU  - Cain, Harry P. II
T1  - The many meanings of 'comprehensive.'
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1964/10//
VL  - 34
IS  - 5
SP  - 834
EP  - 839
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39344-005. Partial author list: First Author & Affiliation: Brown, Bertram S.; Community Mental Health Facilities Branch, National Institute of Mental Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Mental Health; Quality of Services. Minor Descriptor: Community Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 6. Issue Publication Date: Oct, 1964. Publication History: Accepted Date: Jun 15, 1964. 
AB  - 'Comprehensive,' when used to describe a community mental health center, has many meanings. They extend from reference to the range of services available and the variety of people served to reflections of the efforts and the kinds of planning needed to make a comprehensive center a reality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health
KW  - comprehensive center
KW  - mental health center
KW  - service quality
KW  - 1964
KW  - Community Mental Health Services
KW  - Mental Health
KW  - Quality of Services
KW  - Community Services
KW  - 1964
DO  - 10.1111/j.1939-0025.1964.tb02238.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39344-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39344-018
AN  - 2013-39344-018
AU  - O'Donnell, John A.
T1  - A follow-up of narcotic addicts: Mortality, relapse and abstinence.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1964/10//
VL  - 34
IS  - 5
SP  - 948
EP  - 954
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39344-018. Partial author list: First Author & Affiliation: O'Donnell, John A.; Social Science Section, Addiction Research Center, National Institute of Mental Health, Lexington, KY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20170213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Health Care Services; Hospitals; Narcotic Drugs. Minor Descriptor: Public Health. Classification: Substance Abuse & Addiction (3233); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study; Field Study; Interview; Quantitative Study. Page Count: 7. Issue Publication Date: Oct, 1964. Publication History: Accepted Date: Jun 11, 1964. 
AB  - Kentucky residents who were treated for narcotic addiction at the U. S. Public Health Service Hospital, Lexington, Kentucky, between May, 1935 and December, 1959, were followed to determine what happened to them after discharge. Sample size was 266. More than half had died. Of living subjects, more than half were abstinent from narcotics when located. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - narcotic addicts
KW  - mortality
KW  - sample size
KW  - hospitals
KW  - public health
KW  - health services
KW  - 1964
KW  - Drug Addiction
KW  - Health Care Services
KW  - Hospitals
KW  - Narcotic Drugs
KW  - Public Health
KW  - 1964
U1  - Sponsor: National Institutes of Health, US. Grant: M4014. Recipients: No recipient indicated
DO  - 10.1111/j.1939-0025.1964.tb02251.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39344-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Goldsmith, Harold F.
AU  - Copp, James H.
T1  - Metropolitan Dominance and Agriculture.
JO  - Rural Sociology
JF  - Rural Sociology
Y1  - 1964/12//12/1/64
VL  - 29
IS  - 4
M3  - Article
SP  - 385
EP  - 395
SN  - 00360112
AB  - Hypothesizes that agriculture tends to be spatially organized with respect to urban centers. Thus, the level of urbanization and proximity to cities will largely determine land values in a given area. This factor is noted for the Northeastern United States. Some deviation exists where small cities are close to large SMSA's. One of the principles realized here is that, as the size of the largest urban place (city or otherwise) increases, the average value of land and buildings per acre increases. Based on a study of the 299 counties of the Northeastern United States; 2 tables, 14 notes.
KW  - METROPOLITAN areas
KW  - AGRICULTURE
KW  - URBANIZATION
KW  - SOCIAL history
KW  - URBAN policy
KW  - UNITED States
KW  - Land values
N1  - Accession Number: 13249449; Goldsmith, Harold F. 1; Copp, James H. 2; Affiliations: 1 : Project Director, Mental Health Study Center, National Institute of Mental Health.; 2 : Associate Professor of Rural Sociology, The Pennsylvania State University, University Park, Pennsylvania.;  Source Info: 12/1/64, Vol. 29 Issue 4, p385; Historical Period: 1964; Subject Term: METROPOLITAN areas; Subject Term: AGRICULTURE; Subject Term: URBANIZATION; Subject Term: SOCIAL history; Subject Term: URBAN policy; Subject: UNITED States; Number of Pages: 11p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=13249449&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Alderman, Michael H.
T1  - 
JO  - New Republic
JF  - New Republic
J1  - New Republic
PY  - 1964/12/26/
Y1  - 1964/12/26/
VL  - 151
IS  - 26
M3  - Article
SP  - 17
EP  - 20
SN  - 00286583
AB  - Calls for the U.S. government to recognize medical care for the aged as a national obligation as of 1964.  Results of the vague and permissive guidelines established by Congress; Provisions of the Social Security Act of 1960; Weaknesses produced by the state implementation of medical care programs under the Act; Examples of exclusions and limitations that curtail the value of private insurance; Objections of the American Medical Association to Medicare.
KW  - MEDICAL care -- United States
KW  - MEDICAL care for the aged
KW  - SOCIAL security -- Law & legislation
KW  - MEDICARE
KW  - HEALTH insurance -- United States
KW  - UNITED States
N1  - Accession Number: 10013939; Source Information: 12/26/64, Vol. 151 Issue 26, p17; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care for the aged; Subject Term: SOCIAL security -- Law & legislation; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 4p; ; Document Type: Article; 
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=mth&AN=10013939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - mth
ER  - 

TY  - Gen
ID  - 9999-06327-000
AN  - 9999-06327-000
AU  - Schaefer, Earl S.
T1  - Children's Reports of Parental Behavior Inventory
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1965///
AD  - Schaefer, Earl S., National Institute of Mental Health, Laboratory of Psychology, Bethesda, Maryland, United States, 20014
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No
N1  - Accession Number: 9999-06327-000. Partial author list: First Author & Affiliation: Schaefer, Earl S.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20111107. Correction Date: 20120409. Instrument Type: Inventory/Questionnaire. Test Format: Items are rated on a three-point Likert-type scale.. Language: English. Constructs: Parental Behavior; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Children's Reports of Parental Behavior Inventory is to collect and assess child perceptions of parental behavior.
AB  - Description: The Children's Reports of Parental Behavior Inventory (Schaefer, 1965) was developed through a selection of parental-behavior concepts guided by a conceptual model that had been developed from factor analyses of psychologists' ratings of parental behavior. Similar dimensions of authoritarian control and hostile rejection were found in factor analyses of parental-attitude scales. A review of conceptual models for parental behavior also revealed substantial agreement among two-dimensional models that have been independently developed. These conceptual models led to the formulation of a hierarchical conceptual scheme for parental behavior. Four molar dimensions were identified: Autonomy, Love, Control, and Hostility. Several combinations of these dimensions were used to form the concepts measured. Approximately 20 items were written for each concept. Each of three psychologists made a global evaluation of the 20 items for each concept on a three-point scale. A 10-item scale was then developed for each of the 26 concepts from those items which received the highest ratings. The scales were administered to a sample of 7th grade children and a sample of institutionalized delinquent boys. Internal consistency reliabilities were sufficiently high and the scales demonstrated evidence of discriminative validity. (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW  - Children's Reports of Parental Behavior Inventory
KW  - Parent Child Relations
KW  - Child Attitudes
KW  - Attitude Measures
KW  - Test Development
KW  - Internal Consistency
KW  - Test Validity
U5  - Children's Reports of Parental Behavior Inventory [Test Development]Children's reports of parental behavior: An inventory. (AN: 1965-12269-001 from PsycINFO) Schaefer, Earl S.; 1965. Source: Child Development. 36(2), Blackwell Publishing, United Kingdom; 1965; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Samples: Normal 7th Grade Boys and Girls (Aged 12 to 14 Years) and Institutionalized Delinquent Boys (Aged 12 to 18 Years) Keywords: Children's Reports of Parental Behavior Inventory; Parent Child Relations; Child Attitudes; Attitude Measures; Test Development; Internal Consistency; Test Validity; Subjects: Attitude Measures; Child Attitudes; Parent Child Relations; Parental Characteristics; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t06327-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-06327-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-07373-000
AN  - 9999-07373-000
AU  - Haertzen, Charles A.
T1  - Addiction Research Center Inventory: General Drug Control- Estimation Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1965///
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-07373-000. Acronyms: ARCI-DE. Partial author list: First Author & Affiliation: Haertzen, Charles A.; National Institute of Mental Health Addiction Research Center, Lexington, Kentucky, United States. Release Date: 20130107. Correction Date: 20160808. Instrument Type: Rating Scale. Test Format: The response format for this scale is true-false.. Language: English. Constructs: Drug Control Estimation; Classification: Addiction, Gambling, and Substance Abuse/Use (5000). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The ARCI-DE scale is a general drug control-estimator scale that could be used with empirical drug scales to show whether any particular subject is affected by or under the influence of a psychologically active drug.
AB  - Description: The Addiction Research Center Inventory (ARCI) is a 550-item true-false structured personality inventory, similar in format to the MMPI and was devised to measure subjective drug effects as well as psychopathology and personality characteristics. Haertzen (1965) developed a general drug control estimator scale (the General Drug Control- Estimation Scale [DE]) that can be used with empirical drug scales to show whether any particular subject is affected by or under the influence of a psychologically active drug. The DE scale can be considered effective for this purpose if scores on it are reliable, unaffected by drugs and correlated with all empirical drug effect scales. The DE scale meets all three criteria in an opiate addict population. DE is the most reliable scale on the ARCI using test-retest methods. It is as reliable or more reliable than scales in other standard personality inventories including the MMPI, Guilford-Zimmerman Temperament Survey, and the California Psychological Inventory, using the KR-20 internal consistency reliability statistic. The reliability of the scale was very high in several cross validation samples including nonaddict populations. In contrast to empirical drug scales, DE is highly resistant to drug effects. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Addiction Research Center Inventory
KW  - Criterion Validity
KW  - General Drug Control Estimation Scale
KW  - Kuder-Richardson Reliability
KW  - Personality Measures
KW  - Psychopathology
KW  - Self Report
KW  - Test Development
KW  - Test Retest Reliability
KW  - True False
U5  - Addiction Research Center Inventory: General Drug Control- Estimation Scale (ARCI-DE) [Test Development]Addiction Research Center Inventory (ARCI): Development of a general drug estimation scale. (AN: 1966-04754-001 from PsycINFO) Haertzen, Charles A.; 1965. Source: Journal of Nervous and Mental Disease. 141(3), Lippincott Williams & Wilkins, US; 1965; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Sample: Subjects with opiate addiction Keywords: Addiction Research Center Inventory; Criterion Validity; General Drug Control Estimation Scale; Kuder-Richardson Reliability; Personality Measures; Psychopathology; Self Report; Test Development; Test Retest Reliability; True False; Subjects: Drug Addiction; Drug Usage; Drug Usage Screening; Nonprojective Personality Measures; Psychopathology; Self-Report; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t07373-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07373-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-06333-000
AN  - 9999-06333-000
AU  - Schaefer, Earl S.
T1  - Child's Report of Parent Behavior Inventory
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1965///
AD  - Schaefer, Earl S., National Institute of Mental Health, Laboratory of Psychology, Bethesda, Maryland, United States, 20014
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-06333-000. Acronyms: CRPBI. Partial author list: First Author & Affiliation: Schaefer, Earl S.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20130408. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: Participants are asked to indicate whether each item is like or not like their parent.. Language: English. Constructs: Parental Behavior; Perceived Parenting Behaviors; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of this inventory is to measure children's perceptions of their parents' behavior.
AB  - Description: Because a child's perception of his parents' behavior may be more related to his adjustment than is the actual behavior of his parents, the Child's Report of Parent Behavior Inventory (CRPBI; E. S. Schaefer, 1965) was developed. The selection of parental-behavior concepts was guided by a conceptual model that had been developed from factor analyses of psychologists' ratings of parental behavior. A scale for a concept was to consist of 10 homogeneous items that described relevant, specific, observable parental behaviors. Approximately 20 items were written for each concept. Each of three psychologists made a global evaluation of the 20 items for each concept on a three-point scale. The criteria for evaluation were clarity of the behavioral description, relevance of the item to the concept, applicability of the item to both father and mother, and high predicted item variance. A 10-item scale was then developed for each of the 26 concepts from those items which received the highest ratings. The inventory was administered to normal boys and girls aged 12-14 years and institutionalized delinquent boys aged 12-18 years. Both reliability data and analyses of group differences suggest that this inventory provides a sensitive method for investigating children's perceptions of parental behavior. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Discriminant Validity
KW  - Test Development
KW  - Child's Report of Parent Behavior Inventory
KW  - Internal Consistency
U5  - Child's Report of Parent Behavior Inventory (CRPBI) [Test Development]Children's reports of parental behavior: An inventory. (AN: 1965-12269-001 from PsycINFO) Schaefer, Earl S.; 1965. Source: Child Development. 36(2), Blackwell Publishing, United Kingdom; 1965; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Seventh-Grade Children and Institutionalized Delinquent Boys (Ages 12-18); Location: United States Keywords: Discriminant Validity; Test Development; Child's Report of Parent Behavior Inventory; Internal Consistency; Subjects: Child Attitudes; Inventories; Parental Characteristics; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t06333-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-06333-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
T1  - THE RELATION OF FREQUENCY OF SPONTANEOUS SKIN POTENTIAL RESPONSES TO VIGILANCE AND TO AGE.
AU  - Surwillo, Walter W.
AU  - Quilter, Reginald E.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1965/01//
VL  - 1
IS  - 3
SP  - 272
EP  - 276
SN  - 00485772
N1  - Accession Number: 11044659; Author: Surwillo, Walter W.: 1 Author: Quilter, Reginald E.: 1 ; Author Affiliation: 1 National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20040119
N2  - Skin potential (Tarchanoff effect) was recorded in 132 healthy males, aged 22 to 85 years. while they performed an hour-long watchkeeping task. Vigilance level, as measured by S's detection or failure to detect certain critical stimuli, proved to be related to frequency of spontaneous skin potential responses (SPRs) in an interval immediately preceding the stimulus. Low vigilance was associated with fewer spontaneous SPRs per unit of time than high vigilance. This relationship did not appear to be the result of a correlation of the physiological and behavioral variables with time or with age. Old persons evinced a smaller number of spontaneous SPRs in a standard time interval than young persons. Lacey and Lacey's hypothesis that autonomic "labiles," or Ss who show a large number of spontaneous autonomic responses, have shorter reaction times than autonomic "stabiles" was confirmed. A related hypothesis. in which number of erroneous motor responses was the dependent variable. was not substantiated. ABSTRACT FROM AUTHOR
KW  - *GALVANIC skin response
KW  - VIGILANCE (Psychology)
KW  - SIGNAL detection (Psychology)
KW  - CONDITIONED response
KW  - MALES
KW  - BEHAVIORISM (Psychology)
KW  - AGE
KW  - Aging.
KW  - Autonomic
KW  - Skin Potential
KW  - Spontaneous SPR
KW  - Tarchanoff effect
KW  - Vigilance
KW  - Watchkeeping
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2013-39668-002
AN  - 2013-39668-002
AU  - Ozarin, Lucy D.
AU  - Brown, Bertram S.
T1  - New directions in community mental health programs.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1965/01//
VL  - 35
IS  - 1
SP  - 10
EP  - 17
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39668-002. Partial author list: First Author & Affiliation: Ozarin, Lucy D.; Community Mental Health Facilities Branch, National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Continuum of Care; Mental Health Programs. Minor Descriptor: Professional Consultation. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 8. Issue Publication Date: Jan, 1965. 
AB  - New patterns of providing mental health services are emerging. A comprehensive range of readily available services close to where patients live and with continuity of care is the basis of the community mental health center concept. Implementation of the concept has shown that it results in changes in patient care and in professional practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health programs
KW  - mental health services
KW  - continuity of care
KW  - professional practices
KW  - 1965
KW  - Community Mental Health Services
KW  - Continuum of Care
KW  - Mental Health Programs
KW  - Professional Consultation
KW  - 1965
DO  - 10.1111/j.1939-0025.1965.tb02262.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39668-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - Social Class and Family Life (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1965/02//
VL  - 30
IS  - 1
M3  - Book Review
SP  - 149
EP  - 150
SN  - 00031224
AB  - Reviews the book "Social Class and Family Life," by Donald Gilbert McKinley.
KW  - SOCIAL classes
KW  - NONFICTION
KW  - MCKINLEY, Donald Gilbert
KW  - SOCIAL Class & Family Life (Book)
N1  - Accession Number: 12766874; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Feb65, Vol. 30 Issue 1, p149; Subject Term: SOCIAL classes; Subject Term: NONFICTION; Reviews & Products: SOCIAL Class & Family Life (Book); People: MCKINLEY, Donald Gilbert; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Bell, Richard Q.
T1  - DEVELOPMENTAL PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1965/02//
VL  - 16
IS  - 1
M3  - Article
SP  - 1
EP  - 38
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Presents a review of literature in developmental psychology.  Physical growth; Pregnancy and delivery; Early characteristics; Early stimulation; Learning in young organisms; perceptual and motor development; Cognition and language; Mental abilities; Social effects.
KW  - DEVELOPMENTAL psychology
KW  - CHILD development
KW  - CHILDREN
KW  - CHILD psychology
KW  - PSYCHOLOGY
KW  - PERIODICALS
N1  - Accession Number: 11301340; Bell, Richard Q. 1; Affiliations: 1: Child Research Branch, National Institute of Mental Health; Issue Info: 1965, Vol. 16 Issue 1, p1; Subject Term: DEVELOPMENTAL psychology; Subject Term: CHILD development; Subject Term: CHILDREN; Subject Term: CHILD psychology; Subject Term: PSYCHOLOGY; Subject Term: PERIODICALS; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 451310 Book stores and news dealers; Number of Pages: 38p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - GEN
AU  - Mccutchen, C W
T1  - Random code numbers for universal identification of documents
JO  - American Documentation
JF  - American Documentation
Y1  - 1965/04//
VL  - 16
IS  - 2
M3  - Article
SP  - 91
EP  - 96
SN  - 0096946X
AB  - Documents may be difficult to trace through (i) the absence of any visible authors, (ii) long titles laden with information, (iii) remoteness from the library's field of specialization. If every document was given, by the publisher, a random code number of 15 digits split into groups of 3, this could be used as its means of identification. Appendices discuss (i) the generation of random characters using a die and a latin square, (ii) the relative advantages of digits and letters, (iii) multiple assignment of numbers, (iv) cataloguing efficiency of random code numbers.
N1  - Accession Number: ISTA0200201; Mccutchen, C W 1; Affiliations: 1 : Section On Rheumatic Diseases, Laboratory Of Experimental Pathology, National Institutes Of Health, Bethesda, Maryland;  Source Info: April 1965, Vol. 16 Issue 2, p91; Note: Update Code: 0200; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
T1  - ON THE LAW OF INITIAL VALUE AND THE MEASUREMENT OF CHANGE.
AU  - Surwillo, Walter W.
AU  - Arenberg, David L.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1965/04//
VL  - 1
IS  - 4
SP  - 368
EP  - 370
SN  - 00485772
N1  - Accession Number: 19001963; Author: Surwillo, Walter W.: 1 Author: Arenberg, David L.: 1 ; Author Affiliation: 1 National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; No. of Pages: 3; Language: English; Publication Type: Article; Update Code: 20051205
N2  - The article demonstrates the variable change measurements and the application of law of initial value (LIV) test in the study of autonomic variables in every individual within the experimental groups. The measurements on the changes without an intervening stimulus was presented using the criterion on pre-stimulus and post-stimulus values of variables by D. J. Hord, L. C. Johnson and A. Lubin. The LIV was demonstrated by using the heart rate data collected from the group when doing a simple reaction task.
KW  - *HEART beat
KW  - *CARDIAC contraction
KW  - INITIAL value problems
KW  - NUMERICAL analysis
KW  - CRITERION referenced tests
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2013-39904-005
AN  - 2013-39904-005
AU  - Moss, Howard A.
T1  - Methodological issues in studying mother-infant interaction.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1965/04//
VL  - 35
IS  - 3
SP  - 482
EP  - 486
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39904-005. Partial author list: First Author & Affiliation: Moss, Howard A.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1964, Chicago, IL, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Interviews; Methodology; Mother Child Relations. Minor Descriptor: Infant Development. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 5. Issue Publication Date: Apr, 1965. 
AB  - Direct observation is a highly suitable method for studying mother-infant relations. Although there are problems associated with this method they can be allayed through the use of certain tactics. On the other hand, indirect procedures (questionnaires, interviews) have serious limitations that are not easily overcome. The design and methodology of an observational study on mother-infant pairs are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - methodological issues
KW  - mother-infant interaction
KW  - mother-infant relations
KW  - interviews
KW  - 1965
KW  - Interviews
KW  - Methodology
KW  - Mother Child Relations
KW  - Infant Development
KW  - 1965
DO  - 10.1111/j.1939-0025.1965.tb00408.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - GEN
AU  - Brewer, Donna
AU  - Bunting, Sylvia L
T1  - Data processing in clinical chemistry
JO  - Clinical Chemistry
JF  - Clinical Chemistry
Y1  - 1965/05//
VL  - 11
IS  - 5
M3  - Article
SP  - 595
EP  - 611
SN  - 00099147
AB  - The flow of data in the clinical laboratory has been studied with respect to the types of personnel handling it and the ultimate use of the data. In order to promote higher efficiency, a data-processing system using punched cards has been devised and operated for a period of approximately 24 months. Forms, cards, and general considerations useful in such a system are described in detail. Some of the problems associated with this type of operation are discussed, as are the economics of this system and its general applicability.
N1  - Accession Number: ISTA0100303; Brewer, Donna 1; Bunting, Sylvia L; Affiliations: 1 : National Institutes Of Health;  Source Info: May 1965, Vol. 11 Issue 5, p595; Note: Update Code: 0100; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - Human Behavior: An Inventory of Scientific Findings.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1965/06//
VL  - 30
IS  - 3
M3  - Book Review
SP  - 433
EP  - 433
SN  - 00031224
AB  - Reviews the book "Human Behavior: An Inventory of Scientific Findings," by Bernard Berelson and Gary A. Steiner.
KW  - HUMAN behavior
KW  - NONFICTION
KW  - BERELSON, Bernard
KW  - STEINER, Gary A.
KW  - HUMAN Behavior (Book)
N1  - Accession Number: 12768446; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health, Bethesda and Institute for Social Research, Oslo; Issue Info: Jun65, Vol. 30 Issue 3, p433; Subject Term: HUMAN behavior; Subject Term: NONFICTION; Reviews & Products: HUMAN Behavior (Book); People: BERELSON, Bernard; People: STEINER, Gary A.; Number of Pages: 1p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Raskin, Allen
T1  - THE CONCEPT OF TASK VERSUS PERSON ORIENTATION IN NURSING.
JO  - Journal of Applied Psychology
JF  - Journal of Applied Psychology
Y1  - 1965/06//
VL  - 49
IS  - 3
M3  - Article
SP  - 182
EP  - 187
SN  - 00219010
AB  - To clarify the concept of task versus person orientation in nursing, a factor analysis of 24 personality- and nursing-attitude variables was performed on 160 nurses from long- and short-term treatment settings in psychiatry and general medicine. 3 factors, Leadership Skills, Hostile-Self-Seeking, and Dependent-Exploited sampled behaviors in the interpersonal sphere and particularly traits related to leadership capability. The 4th factor, Impersonal- Orderly, contained many characteristics of the "Authoritarian Personality." An emphasis on the skilled technical aspects of nursing was one of the elements in this factor. In general, the derived factor scores effectively differentiated nurses from the treatment settings in this study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Applied Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEADERSHIP
KW  - NURSING
KW  - MEDICINE
KW  - PERSONALITY
KW  - ABILITY testing
KW  - APPLIED psychology
N1  - Accession Number: 12428797; Raskin, Allen 1; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland.; Issue Info: Jun65, Vol. 49 Issue 3, p182; Thesaurus Term: LEADERSHIP; Subject Term: NURSING; Subject Term: MEDICINE; Subject Term: PERSONALITY; Subject Term: ABILITY testing; Subject Term: APPLIED psychology; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Zelen, Marvin
T1  - Statistical Assessment of the Life Characteristic (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1965/06//
VL  - 60
IS  - 310
M3  - Book Review
SP  - 681
SN  - 01621459
AB  - Reviews the book "Statistical Assessment of the Life Characteristic: A Bibliographic Guide," by W.R. Buckland.
KW  - STATISTICS
KW  - NONFICTION
KW  - BUCKLAND, William R.
KW  - STATISTICAL Assessment of the Life Characteristic: A Bibliographic Guide (Book)
N1  - Accession Number: 4605679; Zelen, Marvin 1; Affiliations: 1: National Cancer Institute.; Issue Info: Jun65, Vol. 60 Issue 310, p681; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: STATISTICAL Assessment of the Life Characteristic: A Bibliographic Guide (Book); People: BUCKLAND, William R.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-06071-002
AN  - 2006-06071-002
AU  - Bobbitt, Joseph M.
T1  - Old Folks Not at Home.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1965/06//
VL  - 10
IS  - 6
SP  - 243
EP  - 243
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06071-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Child Health and Human Development, MD, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Distress; Elder Care; Hospitalization; Psychiatric Units; Psychodiagnosis. Minor Descriptor: Hospitals; Schema; Urban Environments. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Lowenthal, Marjorie Fiske. Lives in Distress: The Paths of the Elderly to the Psychiatric Ward=New York: Basic Books, 1964. Pp. xx + 266. $5.95; 1964. Page Count: 1. Issue Publication Date: Jun, 1965. 
AB  - Reviews the book, Lives in Distress: The Paths of the Elderly to the Psychiatric Ward by Marjorie Fiske Lowenthal (see record [rid]1965-02262-000[/rid]). The book tells the story of how elderly people reach the psychiatric screening wards of a large city general hospital--in this case, San Francisco. California. It is a report on how these elderly persons, defined as those sixty years of age or oær, are hospitalized for the first time for psychiatric reasons. It attempts to report and analyze the proximate series of events leading to these hospitalizations. What has been said should indicate that Friske's book is a real contribution to the literature and one that will serve a real purpose. It is necessary, however, to tarnish just a little this highly favorable response by indicating that the book is not highly readable. It tends to present factual statements that fail to achieve great significance or impressivencss because they are not related to conceptual positions or comprehensive schema that give them additional meaning or that make them easy to remember. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric screening wards
KW  - elder care
KW  - distress
KW  - hospitalization
KW  - aged
KW  - gerontology
KW  - 1965
KW  - Distress
KW  - Elder Care
KW  - Hospitalization
KW  - Psychiatric Units
KW  - Psychodiagnosis
KW  - Hospitals
KW  - Schema
KW  - Urban Environments
KW  - 1965
U2  - Lowenthal, Marjorie Fiske. (1964); Lives in Distress: The Paths of the Elderly to the Psychiatric Ward; New York: Basic Books, 1964. Pp. xx + 266. $5.95
DO  - 10.1037/007968
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06071-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06071-009
AN  - 2006-06071-009
AU  - Arnhoff, Franklyn
T1  - Distaff Psychopathology.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1965/06//
VL  - 10
IS  - 6
SP  - 254
EP  - 255
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06071-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Arnhoff, Franklyn; Program Analysis Section, Training and Manpower Resources Branch, National Institute of Mental Health, MD, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Females; Mental Health; Psychopathology; Psychosocial Factors; Schizophrenia. Minor Descriptor: Family Members. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Reviewed Item: Sampson, Harold; Messinger, Sheldon L.; Towne, Robert D. Schizophrenic Women: Studies in Marital Crisis=New York: Atherton Press, 1964. Pp. xiv + 111. $4 95; 1964. Page Count: 2. Issue Publication Date: Jun, 1965. 
AB  - Reviews the book, Schizophrenic Women: Studies in Marital Crisis by Harold Sampson, Sheldon L. Messinger, and Robert D. Towne (see record [rid]1965-08511-000[/rid]). This is the modern Zeitgeist which provides the orientation for the present study: an attempt to provide understanding of the disruption in family living caused by psychiatric crisis and ensuing hospitahzation-a critical period in the lives of all members of the families involved. The study deals with the patterns of life prior to hospitalization, hospitalization itself, and a period following release; what the authors characterize as a sequence of 'organization- disorganization-reorganization. The summary and conclusions of the book provide a good discussion of the social psychological factors and forces impinging upon the mentally disturbed individual as they relate to various tieatment facilities While not new information, it is thoughtful and well presented, providing a short overview for anyone interested in these major, current, social psychological mental health problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health problems
KW  - schizophrenic women
KW  - marital crisis
KW  - social psychological factors
KW  - 1965
KW  - Human Females
KW  - Mental Health
KW  - Psychopathology
KW  - Psychosocial Factors
KW  - Schizophrenia
KW  - Family Members
KW  - 1965
U2  - Sampson, Harold; Messinger, Sheldon L.; Towne, Robert D. (1964); Schizophrenic Women: Studies in Marital Crisis; New York: Atherton Press, 1964. Pp. xiv + 111. $4 95
DO  - 10.1037/007975
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Stachowiak, James G.
AU  - Moss, C. Scott
T1  - HYPNOTIC ALTERATION OF SOCIAL ATTITUDES.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1965/07//
VL  - 2
IS  - 1
M3  - Article
SP  - 77
EP  - 83
SN  - 00223514
AB  - This study measures the effectiveness of influencing S attitudes toward Negroes through the medium of a hypnotically administered communication. Precision was added by conceptualizing the interaction between 2 variables, the concept to be influenced (Negro) and the source of the influence (hypnotist), within the theoretical model provided by Osgood's principle of congruity. Ss who were exposed to a positive communication about Negroes while they were hypnotized showed significantly greater attitude change than did Ss who were exposed to the same communication in the "waking state." Predictions generated by the congruity principle held up well with respect to direction of attitude change, but insufficiencies were evident with regard to predictions of the magnitude of the changes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL influence
KW  - INFLUENCE (Psychology)
KW  - SOCIAL psychology
KW  - ATTITUDE (Psychology)
KW  - FORECASTING
KW  - CHANGE (Psychology)
KW  - DECISION MAKING AND COMMUNICATIONS
KW  - Patterns of opinion spread and opinion change
KW  - Psychological factors affecting tension
N1  - Accession Number: 16643947; Stachowiak, James G. 1; Moss, C. Scott 2; Affiliations: 1 : University of Kansas.; 2 : National Institute of Mental Health, San Francisco, California.;  Source Info: Jul65, Vol. 2 Issue 1, p77; Subject Term: SOCIAL influence; Subject Term: INFLUENCE (Psychology); Subject Term: SOCIAL psychology; Subject Term: ATTITUDE (Psychology); Subject Term: FORECASTING; Subject Term: CHANGE (Psychology); Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Patterns of opinion spread and opinion change; Author-Supplied Keyword: Psychological factors affecting tension; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - 24h
ER  - 

TY  - JOUR
AU  - Boomer, Donald S.
T1  - HESITATION AND GRAMMATICAL ENCODING.
JO  - Language & Speech
JF  - Language & Speech
Y1  - 1965/07//Jul-Sep65
VL  - 8
IS  - 3
M3  - Article
SP  - 148
EP  - 158
PB  - Sage Publications, Ltd.
SN  - 00238309
AB  - The article focuses on a study that concerns in the occurrence of filled and unfilled pauses of hesitations with respect to their location in phonemic clauses in spontaneous English speech. Both types of hesitation were most frequent after the first word in the clause, regardless of length. In this study, the data to be presented concern the location of these hesitations in extended utterances, but the basic theoretical issue involved is the nature of the grammatical encoding process in speech. These data are regarded as directly challenging the transitional probability theory of hesitations. In addition, the phonemic clause is proposed as the encoding unit of speech at the grammatical level.
KW  - Speech -- Study & teaching
KW  - Language & languages -- Study & teaching
KW  - Hesitation form (Linguistics)
KW  - Clauses (Grammar)
KW  - Juncture (Linguistics)
KW  - Linguistics
KW  - Phonetics
KW  - English language -- Study & teaching
KW  - Phonological encoding
N1  - Accession Number: 21832518; Boomer, Donald S. 1,2; Affiliations: 1: National Institute of Mental Health, Bethesda; 2: Laboratory of Psychology, National Institute of Mental Health, National Institutes of Health, Department of Health, Education and Welfare; Issue Info: Jul-Sep65, Vol. 8 Issue 3, p148; Thesaurus Term: Speech -- Study & teaching; Thesaurus Term: Language & languages -- Study & teaching; Thesaurus Term: Hesitation form (Linguistics); Thesaurus Term: Clauses (Grammar); Thesaurus Term: Juncture (Linguistics); Thesaurus Term: Linguistics; Thesaurus Term: Phonetics; Subject Term: English language -- Study & teaching; Subject Term: Phonological encoding; NAICS/Industry Codes: 611630 Language Schools; Number of Pages: 11p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 2013-39739-026
AN  - 2013-39739-026
AU  - Bower, Eli M.
T1  - Review of The tyranny of schooling: An inquiry into the problem of 'stupidity'.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1965/07//
VL  - 35
IS  - 4
SP  - 802
EP  - 804
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39739-026. Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Academic Achievement; Academic Aptitude; Educational Standards. Minor Descriptor: Goals; Mind; Shame. Classification: Academic Learning & Achievement (3550). Population: Human (10). Reviewed Item: Dexter, Lewis Anthony. The tyranny of schooling: An inquiry into the problem of stupidity=New York: Basic Books, 182 pp. $4.50; 1964. Page Count: 3. Issue Publication Date: Jul, 1965. 
AB  - Reviews the book, The Tyranny of Schooling: An Inquiry into the Problem of 'Stupidity' by Lewis Anthony Dexter (see record [rid]1965-02789-000[/rid]). Among the many significant properties of bath water two are to provide a place to sing operatic arias in relative safety and to provide an aqueous propellant to accompany mythical babies being tossed out illusory windows. The book illustrates this second function with full fruition. The author argues that the major goal of the educational institutions is intellectual achievement and that most if not all students do substandard work at one time or another in one subject or another. As a result of this built-in failure, feelings of stupidity or incompetence are developed to less or greater degrees. This, the author believes, is especially applicable to the dull, retarded, or other non-academically minded children. The author feels that schools operate to teach many of the children with superior or normal ability the humiliation and shame of being branded stupid and inadequate. The book considers the problem and several alternatives in a 'variations on a theme' context. This is a kind of desk-pounding, college debating book which tries not to complicate the issues by attempting to understand them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - educational institutions
KW  - intellectual achievement
KW  - goals
KW  - shame
KW  - stupidity
KW  - academic mind
KW  - 1965
KW  - Academic Achievement
KW  - Academic Aptitude
KW  - Educational Standards
KW  - Goals
KW  - Mind
KW  - Shame
KW  - 1965
U2  - Dexter, Lewis Anthony. (1964); The tyranny of schooling: An inquiry into the problem of stupidity; New York: Basic Books, 182 pp. $4.50
DO  - 10.1111/j.1939-0025.1965.tb00456.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39739-032
AN  - 2013-39739-032
AU  - Wiener, Jack
T1  - Mental health highlights.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1965/07//
VL  - 35
IS  - 4
SP  - 813
EP  - 816
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39739-032. Partial author list: First Author & Affiliation: Wiener, Jack; Program Analysis Section, Community Research and Services Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Mental Health Programs; Orthopsychiatry; Scientific Communication. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Jul, 1965. 
AB  - This editorial discusses the present issue of American Journal of Orthopsychiatry which briefly reports the recent legislation, program innovations and program research of national significance to the field of mental health. Mental health history is being made on the Potomac. The year 1965 may prove to be a landmark in the development of the nation's mental health services. Broad social measures, such as the new federal education aid law, presumably will have a general mental health impact. The Appalachia Regional Development Act of 1965 which was approved, has important provisions concerning mental health facilities. The act makes it possible to set up demonstrations of multi-county health centers in several of the isolated and impoverished areas of the region. The Medicare Bill was approved by the House of Representatives on April 8, 1965 and this complex, omnibus bill has important provisions which go beyond services for the aged and directly concern mental health and mental retardation programs. The Child Mental Health Bill is designed to provide federal funds for projects to identify and treat emotionally disturbed children. In 1965, state legislatures in Idaho, North Dakota and Tennessee passed laws authorizing state grants in- id to locally administered community mental health programs. A total of 24 states now have these community mental health acts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - orthopsychiatry
KW  - community mental health services
KW  - scientific communication
KW  - mental health programs
KW  - 1965
KW  - Community Mental Health Services
KW  - Mental Health Programs
KW  - Orthopsychiatry
KW  - Scientific Communication
KW  - 1965
DO  - 10.1111/j.1939-0025.1965.tb00458.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-16485-008
AN  - 2005-16485-008
AU  - Kallen, David J.
T1  - Behavioral Science Research in Growth and Development.
JF  - American Psychologist
JO  - American Psychologist
JA  - Am Psychol
Y1  - 1965/08//
VL  - 20
IS  - 8
SP  - 689
EP  - 691
CY  - US
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
N1  - Accession Number: 2005-16485-008. Partial author list: First Author & Affiliation: Kallen, David J.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavioral Sciences; Experimentation; Human Development. Minor Descriptor: Biology; Cognitive Development; Personality Development; Psychosocial Development. Classification: General Psychology (2100). Population: Human (10). Page Count: 3. Issue Publication Date: Aug, 1965. Copyright Statement: American Psychological Association. 1965. 
AB  - This paper represents an initial attempt to spell out some of the areas which will be given major emphasis by the Behavioral Science Program of the Growth and Development Program, National Institute of Child Health and Human Development (NICHD). Although the Institute feels that these areas are among the most important ones relating to its current program interests, these suggestions are to be regarded as permissive and not controlling. The Institute will be constantly alert to, and willing to support a number of, high-risk projects in which the probabilities of payoff are not great, but in which payoff, if it does occur, would make an exciting, important, and meaningful contribution to the understanding of human growth and development. The paper highlights the areas that will be of primary interest to the program which include: 1)the biological bases and mechanisms of behavior; 2) cognition, learning, perception and environmental mastery; 3) social growth and cultural contexts and; 4) personality development. The author also discusses the importance of linkages. It is important to remain alert to innovations in concept, in method, and in areas of investigation, which will lead to fruitful new approaches to the understanding of human growth and development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - human growth
KW  - behavioral science research
KW  - personality development
KW  - social growth
KW  - cognitive style
KW  - behavior
KW  - linkages
KW  - biology
KW  - 1965
KW  - Behavioral Sciences
KW  - Experimentation
KW  - Human Development
KW  - Biology
KW  - Cognitive Development
KW  - Personality Development
KW  - Psychosocial Development
KW  - 1965
DO  - 10.1037/h0021460
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Asheron, G. L.
AU  - Stone, S. H.
T1  - Selective and Specific Inhibition of 24 Hour Skin Reactions in the Guinea-Pig I. IMMUNE DEVIATION: DESCRIPTION OF THE PHENOMENON AND THE EFFECT OF SPENECTOMY.
JO  - Immunology
JF  - Immunology
Y1  - 1965/09//
VL  - 9
IS  - 3
M3  - Article
SP  - 205
EP  - 217
SN  - 00192805
AB  - Strong 24 hour skin reactions occur in guinea-pigs immunized with antigen in Freund's complete adjuvant. These reactions were reduced by the injection of 1 mg of the same antigen, in either the soluble or alum precipitated form, 14 days before immunization with antigen in Freund's complete adjuvant. There was also a reduction in the corneal reaction, which has been regarded as an index of delayed hypersensitivity. This phenomenon was called immune deviation. The phenomenon was demonstrated for bovine γ-globulin, human serum albumin, bovine serum albumin, egg albumin, diptheria toxoid, hacmocyanin, purified protein derivative (PPD) and dinitrophenylated proteins. Ten mg of soluble bovine γ-globulin caused considerable reduction of the circulating antibody level and of the 24 hour skin reaction. Alum precipitated bovine γ-globulin and smaller doses of soluble antigen reduced the skin reaction but had less effect on the antibody level. Similar results were obtained with human serum albumin. This suggested that the conditions for eliciting immune paralysis and immune deviation were different. Immune deviation was obtained with either footpad or intravenous injections and with as little as 100 µg of antigen. Alum precipitated bovine γ-globulin caused immune deviation when given 14, 7 or 1 day before or 1 day after immunization with antigen in Freund's complete adjuvant. It was inactive when given 6 days after immunization. Splenectomy had no effect on the production or deviation of 24 hour skin reactions. Alum precipitated antigen had a variable and usually slight effect on the level of antibody following immunization with the same antigen in Freund's complete adjuvant. There was, however, a qualitative alteration in the antibody. The sera of guinea-pigs, which had been deviated by a prior injection of bovine serum albumin or bovine γ-globulin, showed only a gamma;1 line of antibody on immunoelectrophoresis, while the sera of control guinea-pigs also showed the γ2 line characteristically seen in guinea-pigs immunized with antigen in Freund's complete adjuvant. It was concluded that immune deviation was distinct from classical immune paralysis and that the immunologically specific reduction of the 24 hour skin reactions might be due, at least in part, to a selective loss of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNIZATION
KW  - ANTIGENS
KW  - DELAYED hypersensitivity
KW  - GLOBULINS
KW  - ALBUMINS
KW  - PROTEINS
KW  - IMMUNOGLOBULINS
KW  - ALUM
KW  - SPLENECTOMY
KW  - ANIMAL models in research
N1  - Accession Number: 13279305; Asheron, G. L. 1; Stone, S. H. 2; Source Information: Sep65, Vol. 9 Issue 3, p205; Subject: IMMUNIZATION; Subject: ANTIGENS; Subject: DELAYED hypersensitivity; Subject: GLOBULINS; Subject: ALBUMINS; Subject: PROTEINS; Subject: IMMUNOGLOBULINS; Subject: ALUM; Subject: SPLENECTOMY; Subject: ANIMAL models in research; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
T1  - AN AUTOMATIC ANALYZER OF STATES OF VIGILANCE.
AU  - Berger, Ralph J.
AU  - Meier, Gilbert W.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1965/10//
VL  - 2
IS  - 2
SP  - 141
EP  - 145
SN  - 00485772
N1  - Accession Number: 11046049; Author: Berger, Ralph J.: 1 Author: Meier, Gilbert W.: 1 ; Author Affiliation: 1 Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20040119
N2  - An assemblage of relay-operated, commercially available programming modules is described. It is capable of discriminating among the states of vigilance - wakefulness (W); high-voltage, slow-wave sleep (HVS); and low-voltage, fast-wave sleep (LVF) - and it requires information from only the nuchal electromyogram (EMG) and the electrooculogram (EOG). ABSTRACT FROM AUTHOR
KW  - *NEURAL analyzers
KW  - *SLEEP
KW  - *CENTRAL nervous system
KW  - VIGILANCE (Psychology)
KW  - SLEEP-wake cycle
KW  - DREAMS
KW  - Analyzer
KW  - Dreaming.
KW  - Sleep
KW  - Vigilance
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
AU  - Stone, Frederick L.
AU  - Brown, J. H. U.
T1  - TECHNOLOGY IN MEDICINE.
JO  - BioScience
JF  - BioScience
Y1  - 1965/11//
VL  - 15
IS  - 11
M3  - Article
SP  - 716
EP  - 719
SN  - 00063568
AB  - The National Institutes of Health are giving widespread support to biomédical engineering research projects and training in a great variety of institutions and settings. Multidisciplinary projects are being conducted in research institutes, general clinical centers, regional primate research centers, hospitals, and medical centers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of BioScience is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Biomedical engineering -- Research
KW  - Interdisciplinary approach in education
KW  - Medical technology
KW  - Research institutes
KW  - Medical centers
KW  - Hospitals
KW  - Medical research
KW  - United States
KW  - National Institutes of Health (U.S.)
N1  - Accession Number: 31932241; Stone, Frederick L. 1; Brown, J. H. U.; Affiliations: 1 : Director, National Institute of General Medical Sciences, National Institutes of Health.;  Source Info: Nov1965, Vol. 15 Issue 11, p716; Subject Term: Biomedical engineering -- Research; Subject Term: Interdisciplinary approach in education; Subject Term: Medical technology; Subject Term: Research institutes; Subject Term: Medical centers; Subject Term: Hospitals; Subject Term: Medical research; Subject: United States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - GEN
AU  - Epstein, Martin N
AU  - Maloney, Clifford J.
T1  - Progress in internal indexing
JO  - In American Documentation Institute. Proceedings Of The Annual Meeting, October 3-7, 1966, Santa Monica, Calif. V. 3. (1966). P. 57-62. See 66-957
JF  - In American Documentation Institute. Proceedings Of The Annual Meeting, October 3-7, 1966, Santa Monica, Calif. V. 3. (1966). P. 57-62. See 66-957
Y1  - 1966///
M3  - Book Chapter
AB  - A method of computer assisted prepartion of internal indexes has been perfected and (hopefully) tested in an operating environment. Index preparation involves both much intellectual discrimination and much clericaldrudgery. The computer is well adapted to performing the latter while actually facilitating performance of the former by a human post editor. As a result, the quality of the output is that of manual indexing, indeed, the computer capabilities encourage and permit the editor to polish his output free of cost and time restraints. The widespread appearance of books, symposia proceedings, and research reports devoid of indexes emphasizes the need. The machine capabilities permit the provision of much fuller indexing than now attempted. The latter facilitates professional rather than author internal indexing.
N1  - Accession Number: ISTA0100747; Epstein, Martin N 1; Maloney, Clifford J. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, M;  Source Info: 1966; Note: Update Code: 0100; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2013-39905-030
AN  - 2013-39905-030
AU  - Wiener, Jack
T1  - Mental health highlights.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/01//
VL  - 36
IS  - 1
SP  - 172
EP  - 175
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39905-030. Partial author list: First Author & Affiliation: Wiener, Jack; Program Analysis Section, Community Research and Services Branch, National Institute of Mental Health, MA, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health; Partial Hospitalization; Project Head Start. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1966. 
AB  - This article presents mental health highlights, which focuses on Older Americans, Manpower in Corrections, Joint Commission on Mental Health of Children, Battered Child, Day Care for Special Children, Ahead of Head Start, and many other related topics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health highlights
KW  - battered child
KW  - day care
KW  - special children
KW  - head start
KW  - 1966
KW  - Mental Health
KW  - Partial Hospitalization
KW  - Project Head Start
KW  - 1966
DO  - 10.1111/j.1939-0025.1966.tb02305.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Dittmann, Allen T.
T1  - PSYCHOTHERAPEUTIC PROCESSES.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1966/02//
VL  - 17
IS  - 1
M3  - Article
SP  - 51
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Examines various literature on psychotherapeutic process.  Methodological discussions; Studies of outcome; Characteristics of patients and therapists; Research on the interview.
KW  - PSYCHOTHERAPY
KW  - PSYCHOLOGICAL literature
N1  - Accession Number: 11298999; Dittmann, Allen T. 1; Affiliations: 1: National Institute of Mental Health in Bethesda, Maryland; Issue Info: 1966, Vol. 17 Issue 1, p51; Subject Term: PSYCHOTHERAPY; Subject Term: PSYCHOLOGICAL literature; Number of Pages: 28p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Burton, Roger V.
AU  - Allinsmith, Wesley
AU  - Maccoby, Eleanor E.
T1  - RESISTANCE TO TEMPATION IN RELATION TO SEX OF CHILD, SEX OF EXPERIMENTER, AND WITHDRAWAL OF ATTENTION.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1966/03//
VL  - 3
IS  - 3
M3  - Article
SP  - 253
EP  - 258
SN  - 00223514
AB  - Sex of E sex of child, withdrawal of attention, and their interactions were tested for their effects on resistance to temptation in 112 4-yr.-old children. The measure of resistance was obtained by testing whether or not a child, when left by himself and tempted to get a high score by cheating, would play a game according to rules established by an adult. Children conformed to the rules more with an adult of the opposite sex. Withdrawal of attention increased heating for boys but had no effect on girls. Several possible interpretations of these results are considered. The desire to please a cross-sex adult, the arousal of achievement motivation by a same-sex adult which may be increased in boys by withdrawal of attention, and resentment at withdrawn attention on the part of boys, could be involved either singly or in combination. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILDREN & sex
KW  - MOTIVATION (Psychology)
KW  - ACHIEVEMENT motivation
KW  - CHILDREN -- Sexual behavior
KW  - SEX education for children
KW  - GENDER role in children
KW  - DECISION MAKING AND COMMUNICATIONS
KW  - Effect of group pressure on individual opinion
KW  - Psychological factors affecting tension
KW  - Social and Cultural Factors Affection Tension
N1  - Accession Number: 16644347; Burton, Roger V. 1; Allinsmith, Wesley 2; Maccoby, Eleanor E. 3; Affiliations: 1 : Laboratory of Socio-Environmental Studies, National Institute of Mental Health, Bethesda, Maryland; 2 : University of Cincinnati; 3 : Stanford University.;  Source Info: Mar66, Vol. 3 Issue 3, p253; Subject Term: CHILDREN & sex; Subject Term: MOTIVATION (Psychology); Subject Term: ACHIEVEMENT motivation; Subject Term: CHILDREN -- Sexual behavior; Subject Term: SEX education for children; Subject Term: GENDER role in children; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Effect of group pressure on individual opinion; Author-Supplied Keyword: Psychological factors affecting tension; Author-Supplied Keyword: Social and Cultural Factors Affection Tension; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - 24h
ER  - 

TY  - GEN
AU  - Haenszel, W
AU  - Lourie, W I, Jr
T1  - Quality control of data in a large-scale cancer register program
JO  - Methods of Information in Medicine
JF  - Methods of Information in Medicine
Y1  - 1966/04//
VL  - 5
IS  - 2
M3  - Article
SP  - 67
EP  - 74
SN  - 00261270
AB  - Quality control of data collected in the united states by the cancer end results program utilizing punchcards prepared by the participating registries in accordance with a uniform punchcard code is dicussed. Existing arrangements decentralize responsibility for editing and related data processing to the local registries with centralization of tabulating and statistical services in the end results section, national cancer institute. The most recent deck of punchcards represented over 600,000 cancer patients; approximately 50,000 newly diagnosed cases are added annually. Mechanical editing and inspection of punchcards and field audits are the principal tools for quality control. Mechanical editing of the punchcards incoudes testing for blank entries and detection of inadmissible or inconsistent codes. Highly improbable codes are subjected to special scrutiny. Field audits include the drawing of 1 to 10 percent random sample of punchcards submitted by a registry; the charts are then reabstracted and recorded by a nci staff member and differences between the punchcards and the results of independent review are noted.
N1  - Accession Number: ISTA0100324; Haenszel, W 1; Lourie, W I, Jr; Affiliations: 1 : National Cancer Institute;  Source Info: April 1966, Vol. 5 Issue 2, p67; Note: Update Code: 0100; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
T1  - SIGNIFICANCE AND RELIABILITY OF SHOCK-IN-DUCED CHANGES IN BASAL SKIN CONDUCTANCE.
AU  - Jones, B. E.
AU  - Ayres, J. J. B.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1966/04//
VL  - 2
IS  - 4
SP  - 322
EP  - 326
SN  - 00485772
N1  - Accession Number: 11047181; Author: Jones, B. E.: 1 Author: Ayres, J. J. B.: 1 ; Author Affiliation: 1 National Institute of Mental Health Addiction Research Center, Lexington, Kentucky.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20031229
N2  - Once weekly for 5 weeks, 15 adult male postaddicts were given 12 to 15 shocks of 5.0 to 8.0 ma. Basal skin conductance (BSC) was recorded during the 25-rain weekly sessions. Increases in BSC during each session and the week-to-week reliabilities of the increases were determined. After the first week, subsequent increases showed reliability coefficients which ranged from 0.69 to 0.95 (P < 0.01). The reliabilities of the increases in BSC produced by shock were considered favorable for the use of change in BSC as a dependent variable in designs requiring repeated measurements on the same Ss at weekly intervals. ABSTRACT FROM AUTHOR
KW  - *GALVANIC skin response
KW  - *REFLEXES
KW  - *SKIN
KW  - *PHYSIOLOGY
KW  - RELIABILITY (Personality trait)
KW  - Basal Skin Conductance. (B. E. Jones)
KW  - Methodology
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
T1  - THE EFFECTS OF SELECTIVE DEPRIVATION OF STATES OF SLEEP IN THE DEVELOPING MONKEY.
AU  - Berger, Ralph J.
AU  - Meier, Gilbert W.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1966/04//
VL  - 2
IS  - 4
SP  - 354
EP  - 371
SN  - 00485772
N1  - Accession Number: 11047250; Author: Berger, Ralph J.: 1 Author: Meier, Gilbert W.: 1 ; Author Affiliation: 1 Laboratory of Perinatal Physiology, National  Institute of Neurological Diseases and Blindness, National  Institutes of Health, San Juan, Puerto Rico.; No. of Pages: 18; Language: English; Publication Type: Article; Update Code: 20031229
N2  - Four groups, two comprising three neonatal rhesus monkeys and two comprising two juvenile rhesus monkeys, were selectively deprived of either low-voltage, fastwave sleep (LVF) or of high.voltage, slow-wave sleep (HVS), respectively. Both infant and juvenile Ss displayed an over-all increase in threshold to the tone-shock combination during the deprivation of either phase of sleep. However, the thresholds of the infant Ss were greater, throughout deprivation, than the thresholds of the juvenile Ss. The juvenile Ss exposed to LVF deprivation were unique in exhibiting a sharp increase in frequency of forced awakenings from LVF, to values significantly greater than for the other groups, and in displaying compensatory recovery effects, manifested by increases in proportion of total sleep time spent in LVF, following termination of deprivation. Behavioral disturbances accompanying deprivation were not evident in any of the experimental groups. The study revealed a number of methodological problems related to the definition and to the selective deprivation of a particular state of sleep. ABSTRACT FROM AUTHOR
KW  - *SLEEP deprivation
KW  - *AROUSAL (Physiology)
KW  - *PSYCHOPHYSIOLOGY
KW  - *ONTOGENY
KW  - Arousal
KW  - Dream deprivation
KW  - Ontogeny. (R. J. Berger)
KW  - Sleep deprivation
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2013-39906-001
AN  - 2013-39906-001
AU  - Shore, Milton F.
T1  - Lip service to research and evaluation?
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/04//
VL  - 36
IS  - 3
SP  - 397
EP  - 398
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39906-001. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Community Mental Health Services; Evaluation; Experimentation; Health Care Services. Minor Descriptor: Scientific Communication. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Apr, 1966. 
AB  - This editorial, discusses, the community mental health center lists as the tenth and last service in a comprehensive community mental health center the area of research and evaluation. Although the order of services written into the Act was not intentional, there has been a tendency on the part of communities which are planning new mental health services to interpret this listing as a model of priorities of service. The development of new techniques does not mean compromising the basic elements of scientific inquiry. It means developing new ways of eliminating biases, testing reliability, selecting control groups, developing measures of subtle behavioral changes. They have an obligation to society and to ourselves as professionals and scientists not only to believe that the services we are giving are effective but to show it in an objective and sophisticated manner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health center
KW  - health services
KW  - evaluation
KW  - research
KW  - scientific inquiry
KW  - 1966
KW  - Community Mental Health Services
KW  - Evaluation
KW  - Experimentation
KW  - Health Care Services
KW  - Scientific Communication
KW  - 1966
DO  - 10.1111/j.1939-0025.1966.tb02381.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39906-002
AN  - 2013-39906-002
AU  - Duhul, Leonard J.
T1  - The President's Crime Commission.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/04//
VL  - 36
IS  - 3
SP  - 398
EP  - 399
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39906-002. Partial author list: First Author & Affiliation: Duhul, Leonard J.; Office of Planning, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Crime Prevention; Law Enforcement; Police Personnel; Public Health. Minor Descriptor: Justice; Laws; Rehabilitation; Safety. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Page Count: 2. Issue Publication Date: Apr, 1966. 
AB  - The President's Crime Commission has invited the American Orthopsychiatric Association to cooperate in the preparation of its report. The Commission invites us to participate in working sessions and in the provision of documents proposing innovations in a variety of areas: the assessment of the scope of the problem, the evaluation of causal factors, the problem of correction and rehabilitation, of law enforcement, public safety and the administration of justice. The Association welcomes the Commission heartily. Just as heartily, it hopes that the final report will reflect the broad viewpoints on crime and its prevention that come from fields other than police and the law alone. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - public safety
KW  - administration of justice
KW  - law enforcement
KW  - rehabilitation
KW  - crime prevention
KW  - police
KW  - laws
KW  - 1966
KW  - Crime Prevention
KW  - Law Enforcement
KW  - Police Personnel
KW  - Public Health
KW  - Justice
KW  - Laws
KW  - Rehabilitation
KW  - Safety
KW  - 1966
DO  - 10.1111/j.1939-0025.1966.tb02382.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39906-013
AN  - 2013-39906-013
AU  - Pollin, William
AU  - Stabenau, James R.
AU  - Mosher, Loren
AU  - Tupin, Joe
T1  - Life history differences in identical twins discordant for schizophrenia.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/04//
VL  - 36
IS  - 3
SP  - 492
EP  - 509
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39906-013. PMID: 5910515 Partial author list: First Author & Affiliation: Pollin, William; Section on Twin and Sibling Studies, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1965, New York, NY, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Life Span; Life Sustaining Treatment; Monozygotic Twins; Schizophrenia. Minor Descriptor: Parents. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Followup Study; Interview; Quantitative Study; Twin Study. References Available: Y. Page Count: 18. Issue Publication Date: Apr, 1966. 
AB  - Eleven pairs of identical twins, in which one had been previously hospitalized for schizophrenia or borderline schizophrenia, have been intensively studied, along with their parents, at the National Institutes of Health. A number of interacting features tend to consistently differentiate the life course of the index from the control twins. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - life history differences
KW  - borderline schizophrenia
KW  - control twins
KW  - identical twins
KW  - life course
KW  - 1966
KW  - Life Span
KW  - Life Sustaining Treatment
KW  - Monozygotic Twins
KW  - Schizophrenia
KW  - Parents
KW  - 1966
DO  - 10.1111/j.1939-0025.1966.tb02393.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-39906-017
AN  - 2013-39906-017
AU  - Waldrop, Mary F.
AU  - Bell, Richard Q.
T1  - Effects of family size and density on newborn characteristics.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/04//
VL  - 36
IS  - 3
SP  - 544
EP  - 550
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-39906-017. PMID: 5910519 Partial author list: First Author & Affiliation: Waldrop, Mary F.; Child Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, New York, NY, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Family Size; Infant Development; Pregnancy. Minor Descriptor: Behavior. Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1966. 
AB  - Infants born to mothers who had experienced a large number of closely spaced pregnancies were found to be more lethargic than infants born to mothers who had experienced fewer pregnancies more widely spaced. Highly lethargic infants on follow-up at age two-and-a-half exhibited greater dependency behavior than children who as infants were low in lethargy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - family size
KW  - density
KW  - newborn characteristics
KW  - infant development
KW  - pregnancy
KW  - dependency behavior
KW  - 1966
KW  - Family Size
KW  - Infant Development
KW  - Pregnancy
KW  - Behavior
KW  - 1966
DO  - 10.1111/j.1939-0025.1966.tb02397.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 84005096
T1  - Doctor Thornton and his Capitol.
AU  - Lindgren, Keith M.
AU  - Lindgren, K M
Y1  - 1966/04/07/
N1  - Accession Number: 84005096. Language: English. Entry Date: 20161119. Revision Date: 20161119. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Architecture -- History
KW  - Public Figures
KW  - United States
KW  - History
KW  - Thornton, W
SP  - 790
EP  - 791
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 274
IS  - 14
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
U2  - PMID: 17926889.
DO  - 10.1056/NEJM196604072741410
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=84005096&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Frome, Julius
T1  - The effects of information storage and retrieval techniques and computers on problems of patentability
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1966/05//
VL  - 6
IS  - 2
M3  - Article
SP  - 66
EP  - 71
SN  - 00219576
AB  - The problems of the effect of information storage and retrieval techniques on patentability are discussed in relation to five areas: computer printouts as 'printed publications'; the implications of computer manipulations of structural formulas and chemical groups; the implications of indexing instructions and code sheets as suggesting combinations to a person skilled in the art; and composition or superimposed random coding interpreted as a reference. Possible solutions to the problems are indicated in relation to quoted judicial decisions.
N1  - Accession Number: ISTA0100197; Frome, Julius 1; Affiliations: 1 : National Institute Of Mental Health;  Source Info: May 1966, Vol. 6 Issue 2, p66; Note: Update Code: 0100; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - THE INTERSECTION DELAY PROBLEM WITH CORRELATED GAP ACCEPTANCE.
JO  - Operations Research
JF  - Operations Research
Y1  - 1966/07//Jul/Aug66
VL  - 14
IS  - 4
M3  - Article
SP  - 614
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - This paper considers a modification of the single-car intersection delay problem in which the waiting driver, upon finding a suitable gap for crossing also examines the succeeding one, and uses it if it is larger. It is shown that the additional delay time caused by this method of gap acceptance is generally quite small. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Operations Research is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOMOBILES
KW  - COMMUTING
KW  - OPERATIONS research
KW  - TRAFFIC flow
KW  - AUTOMOBILE drivers
KW  - LOCOMOTION
KW  - MOTOR vehicles
KW  - AUTOMOTIVE transportation
N1  - Accession Number: 6700762; Weiss, George H. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland.; Issue Info: Jul/Aug66, Vol. 14 Issue 4, p614; Thesaurus Term: AUTOMOBILES; Thesaurus Term: COMMUTING; Thesaurus Term: OPERATIONS research; Subject Term: TRAFFIC flow; Subject Term: AUTOMOBILE drivers; Subject Term: LOCOMOTION; Subject Term: MOTOR vehicles; Subject Term: AUTOMOTIVE transportation; NAICS/Industry Codes: 336110 Automobile and light-duty motor vehicle manufacturing; NAICS/Industry Codes: 415110 New and used automobile and light-duty truck merchant wholesalers; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 811121 Automotive Body, Paint, and Interior Repair and Maintenance; NAICS/Industry Codes: 811198 All Other Automotive Repair and Maintenance; NAICS/Industry Codes: 441110 New Car Dealers; NAICS/Industry Codes: 336111 Automobile Manufacturing; NAICS/Industry Codes: 415190 Recreational and other motor vehicles merchant wholesalers; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 488490 Other Support Activities for Road Transportation; Number of Pages: 5p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2013-41941-005
AN  - 2013-41941-005
AU  - Shore, Milton F.
AU  - Massimo, Joseph L.
T1  - Comprehensive vocationally oriented psychotherapy for adolescent delinquent boys: A follow-up study.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/07//
VL  - 36
IS  - 4
SP  - 609
EP  - 615
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard, E., Adelphi, MD, US, 20783
N1  - Accession Number: 2013-41941-005. PMID: 5936765 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Juvenile Delinquency; Male Delinquency; Program Development; Psychotherapy. Minor Descriptor: Occupational Guidance; Socioeconomic Status. Classification: Criminal Behavior & Juvenile Delinquency (3236); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jul, 1966. 
AB  - A follow-up study of the adolescent delinquent boys participating in a new comprehensive, vocationally-oriented psychotherapy program reported earlier revealed that two to three years following termination the treated boys continued to show major improvement in ego functioning, though at a slower rate than during treatment. An untreated group deteriorated during that time. The results are of significance in planning programs of intervention, especially with lower socioeconomic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - vocationally oriented psychotherapy programs
KW  - adolescent delinquent boys
KW  - lower socioeconomic groups
KW  - program planning
KW  - 1966
KW  - Juvenile Delinquency
KW  - Male Delinquency
KW  - Program Development
KW  - Psychotherapy
KW  - Occupational Guidance
KW  - Socioeconomic Status
KW  - 1966
U1  - Sponsor: Harvard University, Center for Research and Development in Educational Differences, US. Recipients: No recipient indicated
DO  - 10.1111/j.1939-0025.1966.tb02312.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41941-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41941-010
AN  - 2013-41941-010
AU  - Rae-Srant, Quentin A. F.
AU  - Gladwin, Thomas
AU  - Bower, Eli M.
T1  - Mental health, social competence and the war on poverty.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/07//
VL  - 36
IS  - 4
SP  - 652
EP  - 664
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41941-010. Partial author list: First Author & Affiliation: Rae-Srant, Quentin A. F.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Leadership; Poverty; Social Skills; Social Skills Training; War. Minor Descriptor: Cognitive Processes; Mental Health. Classification: Social Processes & Social Issues (2900). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Jul, 1966. 
AB  - Mental health has emphasized reduction of intrapsychic conflict. Increasingly intervention strategies are shifting toward cognitive training for social competence. This trend is traced back to the New Deal and early psychoanalysts. Mental health must reexamine its own strategies if it is to retain leadership within the helping professions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - social competence
KW  - war
KW  - poverty
KW  - cognitive training
KW  - leadership
KW  - 1966
KW  - Leadership
KW  - Poverty
KW  - Social Skills
KW  - Social Skills Training
KW  - War
KW  - Cognitive Processes
KW  - Mental Health
KW  - 1966
DO  - 10.1111/j.1939-0025.1966.tb02317.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41941-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41941-030
AN  - 2013-41941-030
AU  - Flint, Arden A. Jr.
T1  - Review of The psychotherapies of marital disharmonies.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1966/07//
VL  - 36
IS  - 4
SP  - 757
EP  - 758
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41941-030. Partial author list: First Author & Affiliation: Flint, Arden A. Jr.; Child Research Branch, National Institute for Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Marital Conflict; Marriage; Psychotherapy; Relationship Quality. Minor Descriptor: Collaboration. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Greene, Bernard L. (Ed). The psychotherapies of marital disharmonies=New York: The Free Press, 191 pp. $7.95; 1965. Page Count: 2. Issue Publication Date: Jul, 1966. 
AB  - Reviews the book, The psychotherapies of marital disharmonies edited by Bernard L. Greene (1965). The trouble with humanity, some say, is the conflict between instinct and civilization. Others would point to the period of early dependency. The contributors to this hook might suggest a third possibility monogamy- as the basis of our discontent. There is much fog in this book but a few lights manage to shine through. Ackerman makes therapy sound like an adventure, which it can be, and his exploratory questions about the marriage are simple and appropriate. Grotjahn reveals unusual flexibility and humility in his moving description of his work with a family over four years. His admiration for the mother is refreshingly human. Satir crystallizes the central dilemma of marriage when she poses the question of how two people can agree on the same decision and still make room for the uniqueness of each. And Martin and Bird's friendship, described as a collaborative relationship, shows remarkable candor. The forthrightness they have with each other could serve as a model for all relationships, including marriage (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychotherapy
KW  - marital disharmonies
KW  - relationships status
KW  - marriage
KW  - collaborative relationship
KW  - 1966
KW  - Marital Conflict
KW  - Marriage
KW  - Psychotherapy
KW  - Relationship Quality
KW  - Collaboration
KW  - 1966
U2  - Greene, Bernard L. (Ed). (1965); The psychotherapies of marital disharmonies; New York: The Free Press, 191 pp. $7.95
DO  - 10.1037/h0098721
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41941-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Pearlin, Leonard I.
AU  - Kohn, Melvin L.
T1  - SOCIAL CLASS, OCCUPATION, AND PARENTAL VALUES: A CROSS-NATIONAL STUDY.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1966/08//
VL  - 31
IS  - 4
M3  - Article
SP  - 466
EP  - 479
SN  - 00031224
AB  - Despite the considerable difference between Italian and American parents' values for their children, social class is related to parental values in much the same way in both countries. Middle-class parents in both Italy and the United States are more likely to value the child's self-direction, working-class parents the child's conformity to external proscription. Three aspects of occupation - the closeness of supervision to which a man is subjected; whether he works principally with things, with people, or with ideas; and the degree of self-reliance his job requires - are each related to parents' values for their children. Together they account for a large part of the difference between middle- and working-class parents' values, especially for fathers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL classes
KW  - OCCUPATIONS
KW  - VALUES
KW  - MIDDLE class
KW  - PARENTING
KW  - INFLUENCE (Psychology)
KW  - FAMILIES
KW  - ITALY
KW  - UNITED States
KW  - Values (parental)
N1  - Accession Number: 12768487; Pearlin, Leonard I. 1; Kohn, Melvin L. 1; Affiliations: 1 : National Institute of Mental Health;  Source Info: Aug66, Vol. 31 Issue 4, p466; Historical Period: 1966; Subject Term: SOCIAL classes; Subject Term: OCCUPATIONS; Subject Term: VALUES; Subject Term: MIDDLE class; Subject Term: PARENTING; Subject Term: INFLUENCE (Psychology); Subject Term: FAMILIES; Subject: ITALY; Subject: UNITED States; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Myers, J.
AU  - Frei, J. V.
AU  - Cohen, J. J.
AU  - Rose, B.
AU  - Richter, M.
T1  - Basement Membrane Specific Antisera Produced to Solubilized Tissue Fractions.
JO  - Immunology
JF  - Immunology
Y1  - 1966/08//
VL  - 11
IS  - 2
M3  - Article
SP  - 155
EP  - 162
SN  - 00192805
AB  - Attempts were made to produce antisera to solubilized tissue fractions rich in basement membranes and reticulin. Murine tissue fractions solubilized with sodium hydroxide elicited precipitating antibodies upon injection into rabbits. Although no nephrotoxic effect was observed upon injecting the rabbit antisera into mice, the antisera were fixed to the glomerular basement membrane, and not elsewhere, within 5 minutes of injection and remained fixed for at least 3 weeks. Specificity studies suggested that in addition to unique antigens, reticulin and epithelial basement membranes share a common antigen which is responsible for the similar in vitro immunofluorescence produced by antisera to tissue fractions rich in one or the other of these components. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL lamina
KW  - IMMUNE serums
KW  - TISSUES
KW  - SODIUM hydroxide
KW  - IMMUNOGLOBULINS
KW  - RABBITS as laboratory animals
KW  - ANTIGENS
N1  - Accession Number: 13284172; Myers, J. 1; Frei, J. V. 2; Cohen, J. J. 3,4; Rose, B. 3,4; Richter, M. 5; Source Information: Aug66, Vol. 11 Issue 2, p155; Subject: BASAL lamina; Subject: IMMUNE serums; Subject: TISSUES; Subject: SODIUM hydroxide; Subject: IMMUNOGLOBULINS; Subject: RABBITS as laboratory animals; Subject: ANTIGENS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2005-10692-005
AN  - 2005-10692-005
AU  - Ryder, Robert G.
T1  - A Clerically Simple Procedure for Coding Interview Materials.
JF  - American Psychologist
JO  - American Psychologist
JA  - Am Psychol
Y1  - 1966/08//
VL  - 21
IS  - 8
SP  - 812
EP  - 812
CY  - US
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
N1  - Accession Number: 2005-10692-005. Partial author list: First Author & Affiliation: Ryder, Robert G.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Data Collection; Data Processing; Interviews; Methodology. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Methodology: Interview. Page Count: 1. Issue Publication Date: Aug, 1966. Copyright Statement: American Psychological Association. 1966. 
AB  - Work at the Child Research Branch presently includes the application of several thousand (binary) content codes to interview typescripts. The expectable complexities of doing the coding and having the resulting data transcribed accurately for keypunching purposes can easily be imagined. The present procedure, however, virtually eliminates clerical errors, because it virtually eliminates purely clerical operations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - content codes
KW  - interview typescripts
KW  - coding procedure
KW  - clerical error reduction
KW  - 1966
KW  - Data Collection
KW  - Data Processing
KW  - Interviews
KW  - Methodology
KW  - 1966
DO  - 10.1037/h0021033
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Mergenhagen, S. E.
AU  - Notkins, A. L.
AU  - Evans, R. T.
T1  - Passive Haemagglutination for Estimation of Early and Late Anti-Human γ-Globulin Antibodies.
JO  - Immunology
JF  - Immunology
Y1  - 1966/09//
VL  - 11
IS  - 3
M3  - Article
SP  - 223
EP  - 228
SN  - 00192805
AB  - The influence of various concentrations of human y-globulin (HGG) employed to sensitize tanned sheep erythrocytes on haemagglutination titres with various early and late mouse and rabbit antisera to HGG has been studied. The concentration of HGG employed to sensitize tanned erythrocytes which gives the highest haemagglutination titres with early, mercaptoethanol- sensitive antibodies was not optimal for obtaining highest haemagglutination titres with late, mercaptoethanol-insensitive antibodies. Similar results were obtained with heavy and light sucrose gradient ultracentrifugation fractions of a late and early rabbit antiserum. These findings may account for past discrepancies and should be considered when employing the haemagglutination test to detect early and late antibodies.
KW  - GAMMA globulins
KW  - IMMUNOGLOBULINS
KW  - AGGLUTINATION of blood
KW  - IMMUNE serums
KW  - ERYTHROCYTES
KW  - ANTIGEN-antibody reactions
N1  - Accession Number: 14578238; Mergenhagen, S. E.; Notkins, A. L. 1; Evans, R. T. 1; Source Information: Sep66, Vol. 11 Issue 3, p223; Subject: GAMMA globulins; Subject: IMMUNOGLOBULINS; Subject: AGGLUTINATION of blood; Subject: IMMUNE serums; Subject: ERYTHROCYTES; Subject: ANTIGEN-antibody reactions; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Cornfield, Jerome
T1  - A BAYESIAN TEST OF SOME CLASSICAL HYPOTHESES-WITH APPLICATIONS TO SEQUENTIAL CLINICAL TRIALS.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1966/09//
VL  - 61
IS  - 315
M3  - Article
SP  - 577
SN  - 01621459
AB  - Consider someone who sets out to collect data sequentially in such a way as to disprove a hypothesis, H0, about the value of θ, the mean of a normal distribution. Observation is continued as long as the posterior probability of H0 exceeds ai and stopped when it falls below it. It is shown that if a non-zero prior probability, p, is assigned to H0(0≤α1<p) and the remaining prior probability is spread over alternate values of θ that the probability that H0 will eventually be rejected when true is [This eq. cannot bet change in character.] With non-zero assignment of p it is therefore not possible to sample to a foregone conclusion. The Wald 3-decision scheme is shown to be equivalent to setting p = ½ and assigning prior probability of I to the alternatives θ=&tyheta;0+Δ and θ=θ0-Δ. Anomalous features of this scheme, particularly for the case of unknown σ, are shown to be a consequence of the unrealistic nature of the alternatives assumed. It is suggested that meaningful assignments of p are possible in practice by considering the minimum number of cases that would lead one to accept H0 under the most favorable possible evidence for it. Rejection of H0 is shown to be insensitive to choice of p. Closed schemes are obtained by sampling as long as P(θ≤Δ) >α1 and P(θ>0) <α2 and stopping when either inequality is infringed, where Δ is the smallest positive departure from H0 of substantive interest and α1 <α2. Approximating the likelihood function for the logit of a binomial parameter with a normal likelihood function it is possible to extend these methods to the comparison of two binomial parameters, without the usual sequential assumption of pairing and equal number of cases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BAYESIAN analysis
KW  - GAUSSIAN distribution
KW  - PROBABILITY theory
KW  - SAMPLING (Statistics)
KW  - CLINICAL trials
KW  - HYPOTHESIS
KW  - LOGITS
N1  - Accession Number: 4606534; Cornfield, Jerome 1; Affiliations: 1: National Institutes of Health.; Issue Info: Sep66, Vol. 61 Issue 315, p577; Thesaurus Term: BAYESIAN analysis; Thesaurus Term: GAUSSIAN distribution; Thesaurus Term: PROBABILITY theory; Thesaurus Term: SAMPLING (Statistics); Subject Term: CLINICAL trials; Subject Term: HYPOTHESIS; Subject Term: LOGITS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 18p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Mantel, Nathan
AU  - Pasternack, Bernard S.
T1  - LIGHT BULB STATISTICS.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1966/09//
VL  - 61
IS  - 315
M3  - Article
SP  - 633
SN  - 01621459
AB  - Using the concept of an idealized light bulb, one subject to a constant probability of failure while in use, certain distribution problems are solved heuristically. These include: (1) The distribution of sums, or differences, of products of pairs of independent standard normal deviates; (2) The distribution of the difference of 2 chi squares, each with even degrees of freedom or, equivalently, the difference between 2 total waiting times; (3) The distribution of the ratio of 2 chi squares, each with even degrees of freedom or, equivalently, the ratio of 2 total waiting times; (4) Distributions arising in a simple exponential growth process. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - HEURISTIC
KW  - PROBABILITY theory
KW  - UNIFORM distribution (Probability theory)
KW  - FAILURE time data analysis
KW  - LIGHT bulbs
KW  - CHI-squared test
N1  - Accession Number: 4606637; Mantel, Nathan 1; Pasternack, Bernard S. 2; Affiliations: 1: Biometry Branch, National Cancer Institute.; 2: Institute of Environmental Medicine, New York University Medical Center.; Issue Info: Sep66, Vol. 61 Issue 315, p633; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: HEURISTIC; Thesaurus Term: PROBABILITY theory; Subject Term: UNIFORM distribution (Probability theory); Subject Term: FAILURE time data analysis; Subject Term: LIGHT bulbs; Subject Term: CHI-squared test; NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; NAICS/Industry Codes: 416110 Electrical wiring and construction supplies merchant wholesalers; NAICS/Industry Codes: 423610 Electrical Apparatus and Equipment, Wiring Supplies, and Related Equipment Merchant Wholesalers; NAICS/Industry Codes: 335110 Electric Lamp Bulb and Part Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
T1  - Self and Society: Social Change and Individual Development (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1966/10//
VL  - 31
IS  - 5
M3  - Book Review
SP  - 746
EP  - 747
SN  - 00031224
AB  - Reviews the book "Self and Society: Social Change and Individual Development," by Nevitt Sanford.
KW  - SOCIAL change
KW  - NONFICTION
KW  - SANFORD, Nevitt
KW  - SELF & Society (Book)
N1  - Accession Number: 12785708; Rosenberg, Morris 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Oct66, Vol. 31 Issue 5, p746; Thesaurus Term: SOCIAL change; Subject Term: NONFICTION; Reviews & Products: SELF & Society (Book); People: SANFORD, Nevitt; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - Gen
ID  - 9999-05710-000
AN  - 9999-05710-000
AU  - Feld, Sheila C.
T1  - Adolescent Maternal Practices Check List
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1967///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: Unknown. Test Items: Yes
N1  - Accession Number: 9999-05710-000. Partial author list: First Author & Affiliation: Feld, Sheila C.; National Institute of Mental Health, Mental Health Study Center, Adelphi, Maryland, United States. Release Date: 20111010. Correction Date: 20151109. Instrument Type: Checklist. Test Format: Items are rated on a 6-point rating scale.. Language: English. Constructs: Maternal Encouragement; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Adolescent Maternal Practices Check List is to assess maternally encouraged independent accomplishment and mastery in their sons.
AB  - Description: The Adolescent Maternal Practices Check List (Feld, 1967) was developed within the context of a study that attempted to clarify the issue of the relationship between certain childhood experiences and achievement motive in adolescence in males. Winterbottom (1953) found a positive relationship between the n Achievement of boys at ages 8-10 and their mothers' attitudes toward independent accomplishment. This Adolescent Maternal Practices Check List was designed to tap both the achievement and independence dimensions that had been included in Winterbottom's assessment of earlier maternal attitudes toward independent accomplishment (Childhood Maternal Practices Check List). The items of the Adolescent Maternal Practices Check List were designated, on an a priori basis, as being primarily involved with independence, achievement, or behaviors unrelated to independence or achievement attitudes (filler items). The a priori achievement and independence subscales were refined by item analysis. The final achievement subscale consisted of 12 items and the independence subscale of 16 items. The mean of the replies to all items in each subscale was the score on that subscale, with higher scores indicating more encouragement of that set of behaviors. The correlation between the achievement and independence subscales was .56 (p < .01). Consistency over time of maternal attitudes was assessed by comparing the measures obtained from mothers when their sons were adolescents with the reports made to Winterbottom 6 years earlier (N = 17). There was no significant relationship between either of the adolescent maternal attitude subscales and the Childhood Maternal Practices Check List. The direction of the correlations suggested a reversal of maternal attitudes (r = —.39 for the independence subscale and r= —.36 for the achievement subscale); that is, the earlier a mother demanded independent accomplishment from her grade-school- aged son, the less she tended to encourage independence or achievement in her child at adolescence. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Adolescent Maternal Practices Check List
KW  - Mother Child Relations
KW  - Parental Attitudes
KW  - Parental Role
KW  - Test Development
U5  - Adolescent Maternal Practices Check List [Test Development]LONGITUDINAL STUDY OF THE ORIGINS OF ACHIEVEMENT STRIVINGS. (AN: 1968-03775-001 from PsycINFO) FELD, SHEILA C.; Dec, 1967. Source: Journal of Personality and Social Psychology. 7(4, Pt.1), American Psychological Association, US; Dec, 1967; Administration: Paper Age Group: Adolescence (13-17 yrs); Population: Human; Male; Female; Sample: High School Males and Their Mothers Keywords: Adolescent Maternal Practices Check List; Mother Child Relations; Parental Attitudes; Parental Role; Test Development; Subjects: Mother Child Relations; Parental Attitudes; Parental Role; Test Construction;
DO  - 10.1037/t05710-000
L3  - Full; Full text; 999905710_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-18191-000
AN  - 9999-18191-000
AU  - Raskin, Allen
AU  - Schulterbrandt, Joy
AU  - Reatig, Natalie
AU  - Rice, Charles E.
T1  - Inventory of Psychic and Somatic Complaints
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1967///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-18191-000. Other Names: Inventory of Psychic and Somatic Complaints (Patient); Inventory of Psychic and Somatic Complaints (Psychiatrist). Acronyms: IPSC; IPSC (Patient); IPSC (Psychiatrist). Partial author list: First Author & Affiliation: Raskin, Allen; National Institute of Mental Health, United States. Release Date: 20130408. Correction Date: 20160808. Instrument Type: Inventory/Questionnaire. Test Location: Table 1 & 2, Page 272. Test Format: The Inventory of Psychic and Somatic Complaints (psychiatrist) utilizes 7-point degree-of-discomfort scales. The Inventory of Psychic and Somatic Complaints (patient) employs 4-point intensity scales.. Language: English. Constructs: Psychopathology; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Inventory of Psychic and Somatic Complaints is to assess symptoms of psychopathology.
AB  - Description: The Inventory of Psychic and Somatic Complaints (IPSC; Raskin et al., 1967) was developed to assess symptoms of psychopathology. This measure is a modification of the Symptom Distress Scale (Frank et al., 1957) with additional items sampling secondary symptoms of depression. Two forms of the IPSC were created--a psychiatrist-rated version and a patient-rated version. The IPSC (psychiatrist) consists of 41 items, whereas the IPSC (patient) contains 53 items. The 12 additional items in the patient IPSC, as compared to the psychiatrist IPSC, are mainly specific somatic complaints. Factor analysis with Varimax rotation yielded six factors for the IPSC (psychiatrist): Anergia, Hostility, Loss of esteem, Guilt, Anxiety-phobic reactions, and Sleep disturbance. Seven factors were extracted for the IPSC (patient): Anxious depression, Hostility, Morbid obsession, Concomitants of anxiety, Sleep disturbance, Hysteria, and Gastrointestinal and muscular complaints. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Test Development
KW  - Inventory of Psychic and Somatic Complaints
KW  - Test Validity
KW  - Anergia
KW  - Hostility
KW  - Loss of Esteem
KW  - Guilt
KW  - Anxiety-Phobic Reactions
KW  - Sleep Disturbance
KW  - Anxious Depression
KW  - Morbid Obsession
KW  - Concomitants of Anxiety
KW  - Hysteria
KW  - Gastrointestinal and Muscular Complaints
U5  - Inventory of Psychic and Somatic Complaints (IPSC, IPSC (Patient), IPSC (Psychiatrist)) [Test Development]Factors of Psychopathology in Interview, Ward Behavior, and Self-Report Ratings of Hospitalized Depressives. (AN: 2005-10657-003 from PsycINFO) Raskin, Allen; Schulterbrandt, Joy; Reatig, Natalie; Rice, Charles E.; Jun, 1967. Source: Journal of Consulting Psychology. 31(3), American Psychological Association, US; Jun, 1967; Administration: Paper Age Group: Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Inpatient; Sample: Hospitalized Depressed Patients Keywords: Test Development; Inventory of Psychic and Somatic Complaints; Test Validity; Anergia; Hostility; Loss of Esteem; Guilt; Anxiety-Phobic Reactions; Sleep Disturbance; Anxious Depression; Morbid Obsession; Concomitants of Anxiety; Hysteria; Gastrointestinal and Muscular Complaints; Subjects: Anxiety; Factor Analysis; Guilt; Hostility; Hysteria; Major Depression; Obsessions; Physical Disorders; Self-Esteem; Sleep Disorders; Test Construction; Test Validity;
DO  - 10.1037/t18191-000
L3  - Partial; Full text; 999918191_partial_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Liederman, Captain Paul C.
AU  - Green, Richard
AU  - Liederman, Veronica R.
T1  - Outpatient group therapy with geriatric patients.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1967/01//
VL  - 22
IS  - 1
M3  - Article
SP  - 148
EP  - 153
SN  - 0016867X
N1  - Accession Number: 17184685; Liederman, Captain Paul C. 1; Green, Richard 2; Liederman, Veronica R.; Source Information: Jan1967, Vol. 22 Issue 1, p148; Number of Pages: 6p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 2184
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Oppenheim, J. J.
AU  - Wolstencroft, R. A.
AU  - Gell, P. G. H.
T1  - Delayed Hypersensitivity in the Guinea-Pig to a Protein-Hapten Conjugate and its Relationship to <em>in vitro</em> Transformation of Lymph Node, Spleen, Thymus and Peripheral Blood Lymphocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1967/01//
VL  - 12
IS  - 1
M3  - Article
SP  - 89
EP  - 102
SN  - 00192805
AB  - Guinea-pig delayed hypersensitivity to purified protein derivative (PPD) and guinea-pig albumin-orthanilic acid (AO) was produced in the absence of detectable antibody formation to the conjugate. Ten days after sensitization the guinea-pig peripheral leucocytes, lymph nodes, spleen and thymus cell suspensions were cultured from 1 to 5 days with various concentrations of immunizing antigens, unconjugated hapten, a hapten—ovalbumin conjugate or phytohaemagglutinin (PHA). All the cultures of ‘draining’ lymph node cells, and about 40 per cent of the spleen and peripheral leucocyte cultures manifested increased lymphocyte transformation on radioautographs, and by total tritiated thymidine incorporation when stimulated by PPD or AO. In addition all the cultures responded well to PHA. However, lymphocytes from the mediastinal and cervical lymph nodes from the immunized, and most of the lymphoid organ cultures from unimmunized guinea-pigs were not stimulated by antigens but responded only to PHA. Cultured guinea-pig thymocytes did not respond to any stimulus. The in vitro lymphocyte proliferation was carrier specific. It did not occur in response to unconjugated hapten. However, the response to AO was partially inhibited in the presence of the hapten. The in vitro kinetics and morphological changes in the cultures also were investigated, and the immunological significance and specificity of lymphocyte transformation are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALBUMINS
KW  - PROTEINS
KW  - LEUCOCYTES
KW  - KILLER cells
KW  - BLOOD cells
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGY
N1  - Accession Number: 13320964; Oppenheim, J. J. 1; Wolstencroft, R. A. 2; Gell, P. G. H. 2; Source Information: Jan67, Vol. 12 Issue 1, p89; Subject: ALBUMINS; Subject: PROTEINS; Subject: LEUCOCYTES; Subject: KILLER cells; Subject: BLOOD cells; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGY; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 1968-13455-001
AN  - 1968-13455-001
AU  - Bailar, John C.
AU  - Gurian, Joan
T1  - The medical significance of date of birth.
JF  - Eugenics Quarterly
JO  - Eugenics Quarterly
Y1  - 1967///
VL  - 14
IS  - 2
SP  - 89
EP  - 102
CY  - US
PB  - Society for the Study of Social Biology
N1  - Accession Number: 1968-13455-001. PMID: 6063168 Other Journal Title: Biodemography and Social Biology. Partial author list: First Author & Affiliation: Bailar, John C.; National Institutes of Health. Release Date: 19680101. Correction Date: 20161229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Birth; Genetics. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Page Count: 14. Issue Publication Date: 1967. 
AB  - CONCLUDES THAT THERE IS CLEAR EVIDENCE OF MONTH TO MONTH VARIATION IN INFANT MORTALITY AND IN THE OCCURRENCE OF SOME CONGENITAL MALFORMATIONS SUCH AS ANENCEPHALY, PATENT DUCTUS ARTERIOSUS, AND CONGENITAL DISLOCATION OF THE HIP. FURTHER COLLECTING OF SUCH DATA IS USELESS. INSTEAD, TO PERMIT INTERPRETATION, THE SEX RATIO SHOULD BE CHECKED AND MORE IMPORTANTLY SEASONAL VARIATION IN NOXIOUS STIMULI INVESTIGATED. DIFFERENCES IN ABILITY AMONG PERSONS BORN IN CERTAIN MONTHS ARE MENTIONED AS AN EXAMPLE IN NEED OF FINDING THAT KIND OF EXPLANATION. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MONTH OF BIRTH & INFANT MORTALITY & CONGENITAL MALFORMATIONS
KW  - 1967
KW  - Birth
KW  - Genetics
KW  - 1967
DO  - 10.1080/19485565.1967.9987708
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Haenszel, William
T1  - CONCEPT, MEASUREMENT, AND DATA IN MIGRATION ANALYSIS.
JO  - Demography
JF  - Demography
Y1  - 1967/02//
VL  - 4
IS  - 1
M3  - Article
SP  - 253
EP  - 261
SN  - 00703370
AB  - Two methods of computing migration rates-one relating moves to population at risk in place of origin and the other using as a denominator the cross-product of population in. places of origin and destination-are discussed. It is concluded that the second assumes implicitly that moves originate and terminate as a random population variable. Some difficulties with this particular model are pointed out and the author suggests that other analytical approaches to migration data be sought and in this connection refers to the literature on the mathematical theory of epidemics. (English) [ABSTRACT FROM AUTHOR]
AB  - Se discute dos métodos para computar tasas de migración, uno relaciona el desplazamiento con la problación sometida al riesgo en el lugar de origen y el otro que usa como denominador el producto cruzado de la población en los lugares de origen y de destino. Se concluye que el segundo asume implicitamente que los desplazamientos se originan y terminan como una variable poblacional fortuita. Se señalan algunas dificultades con este modelo particular y el autor sugiere que deben buscarse otras perspectivas analiticas para tratar datos sobre migración y en conección con esto se refiere a la literatura sobre la teoria matemática de las epidemias. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EMIGRATION & immigration
KW  - DEMOGRAPHY
KW  - EPIDEMICS
KW  - THEORY
KW  - POPULATION
KW  - EPIDEMIOLOGY
N1  - Accession Number: 16810042; Haenszel, William 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland.; Issue Info: Feb1967, Vol. 4 Issue 1, p253; Thesaurus Term: EMIGRATION & immigration; Thesaurus Term: DEMOGRAPHY; Subject Term: EPIDEMICS; Subject Term: THEORY; Subject Term: POPULATION; Subject Term: EPIDEMIOLOGY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - The Theory of Road Traffic Flow (Book).
JO  - Transportation Science
JF  - Transportation Science
Y1  - 1967/02//
VL  - 1
IS  - 1
M3  - Book Review
SP  - 47
PB  - INFORMS: Institute for Operations Research
SN  - 00411655
AB  - Reviews the book "The Theory of Road Traffic Flow," by Winifred D. Ashton.
KW  - TRAFFIC flow
KW  - NONFICTION
KW  - ASHTON, Winifred
KW  - ASHTON, Winifred D.
KW  - THEORY of Road Traffic Flow, The (Book)
N1  - Accession Number: 4471158; Weiss, George H. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland.; Issue Info: Feb67, Vol. 1 Issue 1, p47; Subject Term: TRAFFIC flow; Subject Term: NONFICTION; Reviews & Products: THEORY of Road Traffic Flow, The (Book); People: ASHTON, Winifred; People: ASHTON, Winifred D.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Hall, William T.
AU  - Claus, George
T1  - ULTRASTRUCTURAL STUDIES ON THE CYANELLES OF CLAUCOCYSTIS NOSTOCHINEARUM ITZIGSOHN.
JO  - Journal of Phycology
JF  - Journal of Phycology
Y1  - 1967/03//
VL  - 3
IS  - 1
M3  - Article
SP  - 37
EP  - 51
PB  - Wiley-Blackwell
SN  - 00223646
AB  - Ultrastructural studies conducted on the intracellular symbiont of Glaucocystis nostochinearum Itz., a unicellular alga with a debated taxonomic position have shown that the endosymbiont, although somewhat aberrant, is a blue-green alga. Due possibly to its intracellular habitat, it lacks the characteristic cyanophycean double-layered cell wall and the cells appear to be completely naked, bound only by a single plasma membrane. The protoplasm of the cell is differentiated into the lamellated chromatoplasm, which contains the photosynthetic pigments and poly-phosphate granules, and a nonlamellar centroplasm, in winch the nucleic material is dispersed. The usual cyanophycean organelles, as well as the different vacuoles and granules, with the exception of the formed bodies, are missing. Approximately 10% of the cells shows a peculiar homogeneous area at one tip, nature of which is unknown. Binary fission the organism is mentioned. Since this cyanelle not yet been classified, we name it Skujapelta nuda nov. gen., nov. sp.; and because of its structural peculiarities we find it necessary to create a new family for it, Skujapeltaceae in the order Chroococcales. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Habitat (Ecology)
KW  - Cell membranes
KW  - Cells
KW  - Biological pigments
KW  - Paint materials
KW  - Art materials
N1  - Accession Number: 11578700; Hall, William T. 1; Claus, George 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014.; 2: Graduate Department of Marine Science, Long Island University, Brookville; Issue Info: Mar1967, Vol. 3 Issue 1, p37; Thesaurus Term: Habitat (Ecology); Thesaurus Term: Cell membranes; Subject Term: Cells; Subject Term: Biological pigments; Subject Term: Paint materials; Subject Term: Art materials; NAICS/Industry Codes: 339940 Office Supplies (except Paper) Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 424950 Paint, Varnish, and Supplies Merchant Wholesalers; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Martin, Jess A
T1  - Medical library internship at nih
JO  - Bulletin of the Medical Library Association
JF  - Bulletin of the Medical Library Association
Y1  - 1967/04//
VL  - 55
IS  - 2
M3  - Article
SP  - 207
EP  - 208
SN  - 00257338
AB  - The intership program for medical librarians sponsored by the national institutes of health was begun in 1964 and was approved by the medical library association. The program ensures a 'planned and balanced development of ... Capabilities,' and' an intensified, systematic, and broad working knowledge and understanding of all phases of librarianship.' an outline of the program is provided.
N1  - Accession Number: ISTA0200239; Martin, Jess A 1; Affiliations: 1 : Library Branch, Division Of Reserch Services, National Institutes Of Health, Bethesda, Maryland;  Source Info: April 1967, Vol. 55 Issue 2, p207; Note: Update Code: 0200; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Carrese, Louis M.
AU  - Baker, Carl G.
T1  - THE CONVERGENCE TECHNIQUE: A METHOD FOR THE PLANNING AND PROGRAMMING OF RESEARCH EFFORTS.
JO  - Management Science
JF  - Management Science
Y1  - 1967/04//
VL  - 13
IS  - 8
M3  - Article
SP  - B-420
EP  - B-438
PB  - INFORMS: Institute for Operations Research
SN  - 00251909
AB  - The difficulties encountered in attempts to apply directly some of the standard network analysis techniques to the planning of research programs are discussed. The particularized requirements for a planning system suitable for research efforts are identified, and a technique developed specifically for the planning and programming of research efforts is described. Basically, the technique involves the formulation of a series of flows and arrays depicting major program elements and individual projects, sequentially ordered on the basis of research logic, and graphically represented by a matrix which relates research performance to resources required (including personnel, materials, equipment and facilities, and funds). Because of the nature of research, the technique was developed to avoid the formulation of tight networks with sharp time-to-completion estimates for each project. The application of this technique to two biomedical research programs of the National Cancer Institute is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Management Science is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STOCHASTIC convergence
KW  - NETWORK analysis (Planning)
KW  - RESEARCH
KW  - OPERATIONS research
KW  - PRODUCTION scheduling
KW  - PLANNING
KW  - BUSINESS planning
KW  - MEDICAL research
KW  - MATRICES
KW  - NETWORK analysis (Communication)
KW  - UNITED States
KW  - NATIONAL Cancer Institute (U.S.)
N1  - Accession Number: 7028113; Carrese, Louis M. 1; Baker, Carl G. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland.; Issue Info: Apr1967, Vol. 13 Issue 8, pB-420; Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: NETWORK analysis (Planning); Thesaurus Term: RESEARCH; Thesaurus Term: OPERATIONS research; Thesaurus Term: PRODUCTION scheduling; Thesaurus Term: PLANNING; Thesaurus Term: BUSINESS planning; Subject Term: MEDICAL research; Subject Term: MATRICES; Subject Term: NETWORK analysis (Communication); Subject: UNITED States ; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 19p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 
TY  - JOUR
ID  - 2005-09867-004
AN  - 2005-09867-004
AU  - Schooler, Carmi
AU  - Tecce, Joseph J.
T1  - Verbal paired-associates learning in chronic schizophrenics as a function of positive and negative evaluation.
JF  - Journal of Abnormal Psychology
JO  - Journal of Abnormal Psychology
JA  - J Abnorm Psychol
Y1  - 1967/04//
VL  - 72
IS  - 2
SP  - 151
EP  - 156
CY  - US
PB  - American Psychological Association
SN  - 0021-843X
SN  - 1939-1846
N1  - Accession Number: 2005-09867-004. PMID: 5623442 Other Journal Title: The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Schooler, Carmi; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060327. Correction Date: 20151019. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evaluation; Paired Associate Learning; Schizophrenia; Verbal Learning. Minor Descriptor: Negative Reinforcement; Positive Reinforcement. Classification: Clinical Psychological Testing (2224); Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Kent-Rosanoff Word Association Test; Rosenberg Self-Esteem Scale DOI: 10.1037/t01038-000; Wechsler Adult Intelligence Scale  (WAIS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1967. Copyright Statement: American Psychological Association. 1967. 
AB  - Seventy-two chronic schizophrenics (36 regressed and 36 partially remitted) and 36 normals were given paired associates of 2 levels of association strength and 2 levels of intralist response competition to learn under positive, negative, and nonevaluation conditions. Regressed schizophrenics showed maximum decrement on low-association word pairs following positive evaluation. This was especially true for those Ss with low self-esteem. These findings suggest that heightened arousal resulting from dissonance between a negative self-image and positive evaluation of performance can lead to behavioral decrement in a difficult task requiring novel associations, such decrement being congruent with the Hull-Spence behavior theory and the Yerkes-Dodson hypothesis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - verbal paired-associates learning
KW  - chronic schizophrenia
KW  - positive evaluation
KW  - negative evaluation
KW  - 1967
KW  - Evaluation
KW  - Paired Associate Learning
KW  - Schizophrenia
KW  - Verbal Learning
KW  - Negative Reinforcement
KW  - Positive Reinforcement
KW  - 1967
DO  - 10.1037/h0020089
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-10656-001
AN  - 2005-10656-001
AU  - Goldberg, Solomon C.
AU  - Mattsson, Nils
T1  - Symptom changes associated with improvement in schizophrenia.
JF  - Journal of Consulting Psychology
JO  - Journal of Consulting Psychology
JA  - J Consult Psychol
Y1  - 1967/04//
VL  - 31
IS  - 2
SP  - 175
EP  - 180
CY  - US
PB  - American Psychological Association
SN  - 0095-8891
N1  - Accession Number: 2005-10656-001. PMID: 6042053 Other Journal Title: Journal of Consulting and Clinical Psychology. Partial author list: First Author & Affiliation: Goldberg, Solomon C.; National Institute of Mental Health, US. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 20060327. Correction Date: 20150119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Judgment (Not Diagnosis); Drug Therapy; Psychiatric Symptoms; Schizophrenia. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Location: US. Tests & Measures: Inpatient Multi-Dimensional Psychiatric Scale; Ward Behavior Rating Scale DOI: 10.1037/t29750-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1967. Copyright Statement: American Psychological Association. 1967. 
AB  - The present study shows that global, clinical judgments of improvement can be predicted by a linear combination of various elements of symptom reduction. This runs counter to the contention of Meehl (1950) that configural, nonlinear combinations are necessary to account for clinical judgment. Of some pragmatic value is the fact that the prediction equation can form the basis of a composite improvement score whose elements of symptom reduction are weighted according to their relationship to the clinically face-valid rating of improvement. This composite is shown to be highly consistent between various drug treatments and between study samples on the same drug treatment. Moreover, it is shown to be a more sensitive discriminator between drug- and placebo-treated patients. The composite is offered as a more sensitive measure of improvement in acute schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - symptom reduction
KW  - clinical judgments of improvement
KW  - symptom changes
KW  - schizophrenia
KW  - drug treatments
KW  - 1967
KW  - Clinical Judgment (Not Diagnosis)
KW  - Drug Therapy
KW  - Psychiatric Symptoms
KW  - Schizophrenia
KW  - 1967
DO  - 10.1037/h0020995
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06065-017
AN  - 2006-06065-017
AU  - Dittmann, Aallen T.
T1  - Psychoanalysis to the Rescue.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1967/04//
VL  - 12
IS  - 4
SP  - 202
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06065-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Dittmann, Aallen T.; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Motivation; Psychoanalysis; Social Sciences. Minor Descriptor: Interviewing; Psychoanalysts. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Hendin, Herbert; Gaylin, Willard; Carr, Arthur. Psychoanalysis and Social Research: The Psychoanalytic Study of the Non-Patient=New York: Doubleday, 1965. Pp. 106. $2.95; 1965. Page Count: 2. Issue Publication Date: Apr, 1967. 
AB  - Reviews the book, Psychoanalysis and Social Research: The Psychoanalytic Study of the Non-Patient by Herbert Hendin, Willard Gaylin, and Arthur Carr (see record [rid]1966-12441-000[/rid]). This modestly titled little volume purports to show that psychoanalytic methods of obtaining data can enrich the research carried on by social scientists. The authors find established social research methods wanting: in interviewing respondents' answers are taken at face value; in statistical and demographic material motivation is not taken into account; and in descriptions of social institutions the resulting characterizations miss the point of the effect of the institutions on the individual. Psychoanalysts should be able to rescue social research on all these points, the authors reason, and it remains only to learn if their interviewing techniques can be applied to normal people as well as to patients in order that psychoanalysis be firmly launched in the social sciences. Almost four-fifths of the pages of the book are devoted to these cases, the first one reported quite fully, the others condensed in varying degrees. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social research
KW  - psychoanalysis
KW  - demographic material motivation
KW  - psychoanalytic methods
KW  - 1967
KW  - Motivation
KW  - Psychoanalysis
KW  - Social Sciences
KW  - Interviewing
KW  - Psychoanalysts
KW  - 1967
U2  - Hendin, Herbert; Gaylin, Willard; Carr, Arthur. (1965); Psychoanalysis and Social Research: The Psychoanalytic Study of the Non-Patient; New York: Doubleday, 1965. Pp. 106. $2.95
DO  - 10.1037/007746
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40223-016
AN  - 2013-40223-016
AU  - Rae-Grant, Quentin
T1  - Discussion: 'The influence of insurance carriers in determining professional practice: New battles but old wars'.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1967/04//
VL  - 37
IS  - 3
SP  - 587
EP  - 593
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40223-016. PMID: 6032949 Partial author list: First Author & Affiliation: Rae-Grant, Quentin; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Insurance; Mental Disorders; Mental Health Services. Minor Descriptor: Health Behavior; Program Development. Classification: Psychological Disorders (3210); Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1967. 
AB  - This article discusses, the field of mental health like the field of general health care, is going through a period of rapid and radical change that amounts to nothing less than a subrevolution. Because of the success that insurance and prepayment programs have had in mitigating the burden of financial expenditure for general health care, there has long been a push, particularly by professionals, for the extension of these plans to cover mental health problems. Thus, insurance coverage is part of the overall battle for more adequate general medical and mental health care for the total populace. Most insurance coverage for mental and emotional disorders is based on the assumptions inherent in the definitions quoted from the American Psychiatric Association's 'Guidelines.' To say that many psychiatrists, as well as psychologists and social workers, do not accept these assumptions is beside the point. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - insurance carriers
KW  - prepayment program
KW  - social workers
KW  - mental health
KW  - health care
KW  - mental health services
KW  - 1967
KW  - Insurance
KW  - Mental Disorders
KW  - Mental Health Services
KW  - Health Behavior
KW  - Program Development
KW  - 1967
DO  - 10.1037/h0097254
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40223-031
AN  - 2013-40223-031
AU  - Wiener, Jack
T1  - Mental health highlights.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1967/04//
VL  - 37
IS  - 3
SP  - 619
EP  - 623
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40223-031. Partial author list: First Author & Affiliation: Wiener, Jack; Center for Studies of Mental Health and Social Problems, Applied Research Branch National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Mental Health; Mental Health Programs; Public Sector. Minor Descriptor: Addiction; Laws; Narcosis. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 5. Issue Publication Date: Apr, 1967. 
AB  - The current article highlights the 'mental health' in the titles of any of the federal laws listed below. But each of the laws has some provision which makes it possible to expand mental health programs. It is hard to find common elements in the laws but the words that stand out in more than one law are : 'planning,' 'comprehensive health services,' 'the poor,' and 'narcotic addiction.' Even when it comes to getting their children into a public institution for the retarded, the well-to-do are more successful than the poor. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - mental health programs
KW  - health services
KW  - public institution
KW  - narcotic addiction
KW  - laws
KW  - 1967
KW  - Health Care Services
KW  - Mental Health
KW  - Mental Health Programs
KW  - Public Sector
KW  - Addiction
KW  - Laws
KW  - Narcosis
KW  - 1967
DO  - 10.1111/j.1939-0025.1967.tb00499.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Ben-Efraim, S.
AU  - Fuchs, Sara
AU  - Sela, M.
T1  - Differences in Immune Response to Synthetic Antigens in Two Inbred Strains of Guinea-Pigs.
JO  - Immunology
JF  - Immunology
Y1  - 1967/05//
VL  - 12
IS  - 5
M3  - Article
SP  - 573
EP  - 581
SN  - 00192805
AB  - The study of the immunogenicity of some linear and multichain synthetic polypetides in guinea-pigs, of inbred strains 2 and 13 led to their division into three categories: (a) immunogenic in both inbred strains: linear copolymer of tyrosine, glutamic acid and alanine; (b) irnmunogenic in strain 13 and negative in strain 2: linear copolymer of tyrosine and glutamic acid; and (c) immunogenic in strain 2 and negative in strain 13 : linear and branched copolymers containing lysine. No immune response was detected in strain 2 guinea-pigs to the copolymer of tyrosine, glutamic acid and lysine, composed only of the D-optical isomers. The immune response, or lack of response, in F1 hybrids of the inbred strains was identical with that of inbred strain 2 suggesting that the genetic determinants of this strain are dominant. No cross-reactions were observed at the delayed stage in inbred strain 2 between linear and multichain copolymers of similar composition.
KW  - PEPTIDES
KW  - TYROSINE
KW  - GLUTAMIC acid
KW  - ALANINE
KW  - LYSINE
KW  - COPOLYMERS
KW  - OPTICAL isomers
KW  - GUINEA pigs as laboratory animals
N1  - Accession Number: 13331987; Ben-Efraim, S. 1,2; Fuchs, Sara 1,2; Sela, M. 1,2; Source Information: May67, Vol. 12 Issue 5, p573; Subject: PEPTIDES; Subject: TYROSINE; Subject: GLUTAMIC acid; Subject: ALANINE; Subject: LYSINE; Subject: COPOLYMERS; Subject: OPTICAL isomers; Subject: GUINEA pigs as laboratory animals; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - CONF
AU  - Cosmides, George J.
AU  - Rall, David P.
T1  - International Symposium on Comparative Pharmacology.
JO  - BioScience
JF  - BioScience
Y1  - 1967/06//
VL  - 17
IS  - 6
M3  - Proceeding
SP  - 413
EP  - 416
SN  - 00063568
AB  - The article offers information on the International Symposium on Comparative Pharmacology that took place in Washington D.C. during January 24-27, 1967. The symposium made known areas of research in which the techniques of various disciplines can be employed, species new to laboratory investigation. The members for the Program Planning Committee for the symposium include chairman E.J. Cafruny of the University of Minnesota, G.J. Cosmides of the National Institute of General Medical Sciences.
KW  - Conferences & conventions
KW  - Pharmacology -- Congresses
KW  - Washington (D.C.)
KW  - Cafruny, E. J.
KW  - Cosmides, G. J.
N1  - Accession Number: 31990883; Cosmides, George J. 1; Rall, David P. 1; Affiliations: 1 : National Institutes of Health, Bethesda, Maryland.;  Source Info: Jun1967, Vol. 17 Issue 6, p413; Subject Term: Conferences & conventions; Subject Term: Pharmacology -- Congresses; Subject: Washington (D.C.); Number of Pages: 4p; Document Type: Proceeding
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Dittmann, Allen T.
AU  - Lynn, D.
AU  - Llewellyn, G.
T1  - THE PHONEMIC CLAUSE AS A UNIT OF SPEECH DECODING.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1967/07//
VL  - 6
IS  - 3
M3  - Article
SP  - 341
EP  - 349
SN  - 00223514
AB  - It is argued here that spoken language is decoded by the listener in word groups called phonemic clauses. Behavioral data, the location of listener responses in relation to the speaker's phonemic clauses, provide the evidence. Pairs of Ss spoke to each other alternately on topics of mutual interest in a situation resembling that of a telephone conversation. The listeners were instructed to let the speakers know that they were listening and interested. Their responses were found to be located almost exclusively at the ends of the speakers' phonemic clauses rather than within them, whether or not there were hesitations at either point. Further, only those types of clause ending which sound most "final" were followed by listener responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Phonemics
KW  - Language & languages
KW  - Speech
KW  - Behavioral assessment
KW  - Conversation
KW  - Oral communication
N1  - Accession Number: 16688755; Dittmann, Allen T. 1; Lynn, D. 1; Llewellyn, G. 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: Jul67, Vol. 6 Issue 3, p341; Thesaurus Term: Phonemics; Thesaurus Term: Language & languages; Thesaurus Term: Speech; Thesaurus Term: Behavioral assessment; Thesaurus Term: Conversation; Thesaurus Term: Oral communication; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 2006-06102-009
AN  - 2006-06102-009
AU  - Yarrow, Leon J.
T1  - In Need of Theory.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1967/07//
VL  - 12
IS  - 7
SP  - 347
EP  - 348
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06102-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavior Change; Child Care; Childhood Development; Recovery (Disorders). Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: Flint, Betty M. The Child and the Institution: A Study of Deprivation and Recovery=Ontario, Canada: University of Toronto Press, 1966. Pp. xii + 177. $7.50; 1966. Page Count: 2. Issue Publication Date: Jul, 1967. 
AB  - Reviews the book, The Child and the Institution: A Study of Deprivation and Recovery by Betty M. Flint (see record [rid]1966-06769-000[/rid]). At a time when we are seeking new models of childcare, particularly for children whose parents are absent or inadequate, this account of an effort to institute radical changes in a traditional child care institution is especially interesting. Several chapters in the present book consist of detailed case histories of children from the time of entrance into the institution through the period following the change. These case discussions do not add much depth to our understanding of the changes which occurred since the descriptions of the children are restricted to the terms of the rating scales. There is little attempt to integrate the case data in terms of concepts at a higher order of complexity than those contained in the rating scales. A number of important theoretical issues are hinted at, but never fully developed. There are some suggestions that the behavioral changes observed in the children might have been situational rather than at a deep characterological level. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - deprivation
KW  - recovery
KW  - children
KW  - behavioral changes
KW  - 1967
KW  - Behavior Change
KW  - Child Care
KW  - Childhood Development
KW  - Recovery (Disorders)
KW  - 1967
U2  - Flint, Betty M. (1966); The Child and the Institution: A Study of Deprivation and Recovery; Ontario, Canada: University of Toronto Press, 1966. Pp. xii + 177. $7.50
DO  - 10.1037/009187
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06102-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40696-011
AN  - 2013-40696-011
AU  - Wender, Paul H.
AU  - Pedersen, Frank A.
AU  - Waldrop, Mary F.
T1  - A longitudinal study of early social behavior and cognitive development.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1967/07//
VL  - 37
IS  - 4
SP  - 691
EP  - 696
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40696-011. PMID: 6033423 Partial author list: First Author & Affiliation: Wender, Paul H.; National Institutes of Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1966, San Francisco, CA, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Cognitive Ability; Cognitive Development; Cognitive Style; Nursery Schools; Social Behavior. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Tests & Measures: Wechsler Intelligence Scale for Children-Short Form; Children's Embedded Figures Test. Methodology: Empirical Study; Followup Study; Longitudinal Study; Interview; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 1967. 
AB  - Thirty boys who had been studied in a research nursery school when they were two and a half were re-evaluated when they were six and a half. Early social differences tended to correlate with later intellectual ones; children who were socially dependent in nursery school tended to show a less abstract cognitive style and lower nonverbal intellectual functioning when older. Four cases are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - early social behavior
KW  - cognitive development
KW  - nursery schools
KW  - cognitive style
KW  - intellectual functioning
KW  - 1967
KW  - Cognitive Ability
KW  - Cognitive Development
KW  - Cognitive Style
KW  - Nursery Schools
KW  - Social Behavior
KW  - 1967
DO  - 10.1111/j.1939-0025.1967.tb00510.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40696-022
AN  - 2013-40696-022
AU  - Bower, Eli M.
T1  - American children and families in overseas communities.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1967/07//
VL  - 37
IS  - 4
SP  - 787
EP  - 796
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40696-022. PMID: 6033434 Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Cross Cultural Differences; Family; Mental Health. Minor Descriptor: Childhood Development. Classification: Community & Social Services (3373). Population: Human (10). Location: Europe. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1967. 
AB  - A significant number of American families, military and civilian, are based in Europe. Does living in a foreign culture have any positive or negative emotional impact on these families and their children? How adequate are the mental health and educational resources provided by the military? What new services might be needed for such communities? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - American familiies
KW  - children development
KW  - communities
KW  - cross cultural differences
KW  - mental health
KW  - 1967
KW  - Community Services
KW  - Cross Cultural Differences
KW  - Family
KW  - Mental Health
KW  - Childhood Development
KW  - 1967
DO  - 10.1111/j.1939-0025.1967.tb00521.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40696-022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Datta, Lois-Ellin
T1  - FAMILY RELIGIOUS BACKGROUND AND EARLY SCIENTIFIC CREATIVITY.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1967/08//
VL  - 32
IS  - 4
M3  - Article
SP  - 626
EP  - 635
SN  - 00031224
AB  - That achievement in the area of science varies systematically with religious background has been reported by some and cited by many. The inference is drawn that some values and attitudes associated with particular religious backgrounds are more conducive to scientific interest and achievement than are those associated with other religious backgrounds. The purpose of this study was to determine if the reported relationship between religion and 'creative' achievement found among adult male scientists was also found among adolescents who varied in potential scientific creativity as demonstrated by the projects they submitted to the Westinghouse Science Talent Search. In the adolescent sample, the potential scientific creativity ratings of projects submitted by students from Jewish families were higher than were the ratings of projects submitted by students from Catholic, 'liberal' Protestant, and 'fundamentalist' Protestant backgrounds. Interpretations of the religious background distributions that directly relate ascribed group values to the development of potential scientific creativity would be misleading, however, since the association was markedly reduced for Ss from larger cities and statistically reliable only for Ss from smaller hometowns and lower socioeconomic status. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CREATIVE ability in science
KW  - RELIGION & science
KW  - SCIENTISTS
KW  - CALVINISTS
KW  - SOCIALIZATION
KW  - PROTESTANTS
KW  - FAMILIES
KW  - RELIGION
KW  - ADOLESCENCE
KW  - Scientific creativity
N1  - Accession Number: 12883880; Datta, Lois-Ellin 1; Affiliations: 1 : National Institutes of Health.;  Source Info: Aug67, Vol. 32 Issue 4, p626; Historical Period: 1967; Subject Term: CREATIVE ability in science; Subject Term: RELIGION & science; Subject Term: SCIENTISTS; Subject Term: CALVINISTS; Subject Term: SOCIALIZATION; Subject Term: PROTESTANTS; Subject Term: FAMILIES; Subject Term: RELIGION; Subject Term: ADOLESCENCE; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - GEN
AU  - Frome, Julius
T1  - An experimental practical approach to current awareness
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1967/08//
VL  - 7
IS  - 3
M3  - Article
SP  - 135
EP  - 137
SN  - 00219576
AB  - A practical experimental approach for a low cost current awareness system, which was fitted into an ongoing computer retrieval system, combines the functions of a science newspaper in the field as well as a current accessions bulletin. It can provide users with cards of abstracts of the articles upon request. The low cost is achieved by using mainly the computer input and output of the already existing retrievel system. The system is responsive to monthly changes in interest. It is expandable with little additional cost.
N1  - Accession Number: ISTA0300149; Frome, Julius 1; Affiliations: 1 : National Clearinghouse Of Mental Health Information, National Institute Of Mental Health, Md.;  Source Info: August 1967, Vol. 7 Issue 3, p135; Note: Update Code: 0300; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Halperin, Max
AU  - Rastogi, Suresh C.
AU  - Ho, Irwin
AU  - Yang, Y. Y.
T1  - SHORTER CONFIDENCE BANDS IN LINEAR REGRESSION.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1967/09//
VL  - 62
IS  - 319
M3  - Article
SP  - 1050
SN  - 01621459
AB  - In many linear regression problems, the values of the independent variable or variables may be subject to certain constraints. For example, the independent variables may necessarily be positive; as another example, the variables may not only all be positive but are powers of a single variable (e.g., polynomial regression on time). Previous writers considering the problem of obtaining confidence bands on a regression function for all values of the independent variable have not utilized such constraints; the usual basis for such bands has been the multiple comparison procedure of Scheffe which places no constraints at all upon the independent variables. Any procedure utilizing constraints will necessarily yield a uniform improvement over the method of Scheffe (assuming both methods are applicable) in the sense of yielding narrower bands for a given confidence probability. In the present paper a nontrivial lower bound is obtained for the confidence probability associated with a multiple comparison procedure appropriate to the case where it can be assumed that each independent variable must be of specified sign; this includes, as a subclass, polynomial regression on a non-negative independent variable. This result gives a basis for a multiple comparison procedure less conservative than that of Scheffe when both are applicable. Implementation of the procedure requires the percentage points of a heretofore untabulated distribution. Tables of percentage points of this distribution appropriate to linear combinations of two, three, or four parameters are presented. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - REGRESSION analysis
KW  - MATHEMATICAL statistics
KW  - PROBABILITY theory
KW  - CORRELATION (Statistics)
KW  - ANALYSIS of variance
KW  - VARIABLES (Mathematics)
N1  - Accession Number: 4605495; Halperin, Max 1; Rastogi, Suresh C. 2; Ho, Irwin 2; Yang, Y. Y. 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland.; 2: Institute of International Medicine, University of Maryland.; Issue Info: Sep67, Vol. 62 Issue 319, p1050; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: ANALYSIS of variance; Subject Term: VARIABLES (Mathematics); Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2005-09870-005
AN  - 2005-09870-005
AU  - Lloyd, Dee Norman
T1  - Overinclusive thinking and delusions in schizophrenic patients: A critique.
JF  - Journal of Abnormal Psychology
JO  - Journal of Abnormal Psychology
JA  - J Abnorm Psychol
Y1  - 1967/10//
VL  - 72
IS  - 5, Pt.1
SP  - 451
EP  - 453
CY  - US
PB  - American Psychological Association
SN  - 0021-843X
SN  - 1939-1846
N1  - Accession Number: 2005-09870-005. Other Journal Title: The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Lloyd, Dee Norman; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Style; Delusions; Schizophrenia; Thinking. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1967. Copyright Statement: American Psychological Association. 1967. 
AB  - Because of an error in the statistical paradigm, it is felt that conclusions of a study by R. W. Payne et al (see record [rid]1965-05763-001[/rid]) were not supported by their data. The average number of words to explain proverbs, a measure in that study, was calculated for 13 delusional, 13 suspected delusional, and 16 nondelusional schizophrenics. Significant difference among these groups was found, supporting the hypothesis that this measure is related to presence of delusions. Because of the purely quantitative nature of the measure and the possibility that it measures functions other than overinclusion, however, it was concluded that results using only this measure are not sufficient to support the proposed theoretical connection between overinclusion and the development of delusions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - overinclusive thinking
KW  - delusions
KW  - schizophrenic patients
KW  - 1967
KW  - Cognitive Style
KW  - Delusions
KW  - Schizophrenia
KW  - Thinking
KW  - 1967
DO  - 10.1037/h0020110
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40698-016
AN  - 2013-40698-016
AU  - Dumont, Matthew P.
T1  - Tavern culture the sustenance of homeless men.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1967/10//
VL  - 37
IS  - 5
SP  - 938
EP  - 945
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40698-016. PMID: 6054549 Partial author list: First Author & Affiliation: Dumont, Matthew P.; Center for Studies of Metropolitan, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Welfare Services; Homeless. Minor Descriptor: Human Males; Personnel. Classification: Community & Social Services (3373). Population: Human (10); Male (30). References Available: Y. Page Count: 8. Issue Publication Date: Oct, 1967. Publication History: First Submitted Date: Aug 12, 1966. 
AB  - The needs of homeless men are not being met by health and welfare agencies. Observations of one community of such men reveals that a bartender and his tavern provide for many of these needs. Professionals can utilize the barroom as a point of intervention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - homeless men
KW  - welfare agencies
KW  - communities
KW  - professionals
KW  - 1967
KW  - Community Welfare Services
KW  - Homeless
KW  - Human Males
KW  - Personnel
KW  - 1967
DO  - 10.1111/j.1939-0025.1967.tb00540.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40698-027
AN  - 2013-40698-027
AU  - Twain, David C.
T1  - Review of Street corner research.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1967/10//
VL  - 37
IS  - 5
SP  - 987
EP  - 988
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40698-027. Partial author list: First Author & Affiliation: Twain, David C.; Center for Studies of Crime and Delinquency, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Media. Language: English. Major Descriptor: Community Mental Health Training; Juvenile Delinquency; Operant Conditioning; Training. Minor Descriptor: Films; Mental Health; Personnel. Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: Mason, Edward A. (Prod). Street corner research=30-minute, 16mm, black and white, sound film. Rental: Arranged. Purchase: $135. Center for Mass Communications, Columbia University Press, 440 West 110th St., New York, N.Y. 10025; 1967. Page Count: 2. Issue Publication Date: Oct, 1967. 
AB  - Reviews the film, Street Corner Research produced by Edward A. Mason (1967). The film 'Street Corner Research' vividly depicts the use of operant conditioning theory and techniques in contacting and eventually developing a meaningful relationship among delinquents, our 'research experts' above, and those persons interested in modifying delinquent behavior. The film shows us the contact, the soliciting of cooperation, and one interview session with a small group (two boys and a girl), at least one of whom is identified as 'delinquent.' This film is intended for the training of workers in the mental health field. This is an honest film, but perhaps too naive in oversimplifying the role of soft drinks and potato chips as reinforcers of desired behavior in a complex interpersonal situation. The film could have gone much further in documenting the background. It could have described more fully the aims and objectives, methods, personnel, and complex situations encompassed in the exciting and innovative community-based intervention program for delinquency control that is presented. The film does, however, clearly make the point that the hard-to-reach, hard to-counsel delinquent can be brought into a program with behavior-change potential. And it shows a technique which can be used by professional and nonprofessional alike as a working tool in delinquency control programs. and failures of 'street corner research.' It could have described more fully the aims and objectives, methods, personnel, and complex situations encompassed in the exciting and innovative community-based intervention program for delinquency control that is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - audio visuals
KW  - films
KW  - operant conditioning theory
KW  - delinquent behavior
KW  - workers training
KW  - mental health
KW  - community based intervention
KW  - 1967
KW  - Community Mental Health Training
KW  - Juvenile Delinquency
KW  - Operant Conditioning
KW  - Training
KW  - Films
KW  - Mental Health
KW  - Personnel
KW  - 1967
U2  - Mason, Edward A. (Prod). (1967); Street corner research; 30-minute, 16mm, black and white, sound film. Rental: Arranged. Purchase: $135. Center for Mass Communications, Columbia University Press, 440 West 110th St., New York, N.Y. 10025
DO  - 10.1037/h0097141
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40698-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Asherson, G. L.
AU  - Stone, S. H.
T1  - Desensitization <em>in vitro</em>-The Specific Inhibition, by Antigen, of the Passive Transfer of Delayed Hypersensitivity by Peritoneal Exudate Cells.
JO  - Immunology
JF  - Immunology
Y1  - 1967/11//
VL  - 13
IS  - 5
M3  - Article
SP  - 469
EP  - 475
SN  - 00192805
AB  - A preliminary experiment showed that the injection of bovine γ-globulin into guinea-pigs with delayed hypersensitivity to bovine γ-globulin reduced the 24-hour skin reactions to bovine γ-globulin and (to a lesser extent) PPD. The peritoneal exudate cells from the desensitized donors had a reduced ability to transfer delayed hypersensitivity to bovine γ-globulin but a normal ability to transfer delayed hypersensitivity to PPD. Likewise, it was possible to diminish the passive transfer of delayed hypersensitivity to bovine γ-globulin by peritoneal exudate cells, by exposure of the ceils to bovine γ-globulin in vitro. The recipients were tested immediately after cell transfer. This in vitro desensitization was specific, in that the transfer of delayed hypersensitivity to PPD was unaffected. Exposure of cells in vitro to hypotonic conditions and antibody to guinea-pig γ-globulin did not prevent the passive transfer of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALLERGY desensitization
KW  - ALLERGY
KW  - GLOBULINS
KW  - ANTIGENS
KW  - ANIMAL models in research
KW  - IMMUNOLOGY
N1  - Accession Number: 13342845; Asherson, G. L. 1; Stone, S. H. 2; Source Information: Nov67, Vol. 13 Issue 5, p469; Subject: ALLERGY desensitization; Subject: ALLERGY; Subject: GLOBULINS; Subject: ANTIGENS; Subject: ANIMAL models in research; Subject: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Bryan, S
AU  - Epstein, M
T1  - Computer assisted primary index preparation
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1967/11//
VL  - 7
IS  - 4
M3  - Article
SP  - 223
EP  - 2321
SN  - 00219576
AB  - A man-machine primary indexing system employing a special 'indexing language' called bicept is fully described. The system is applicable for computer-processed or non-machine-readable text. It differs from most other machine indexing projects in that the specification of index items is largely manual. The method was applied to a journal article in an operational test.
N1  - Accession Number: ISTA0300927; Bryan, S 1; Epstein, M; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland 20014;  Source Info: November 1967, Vol. 7 Issue 4, p223; Note: Update Code: 0300; Number of Pages: 2099p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Bartko, John J.
T1  - Variance Analysis of Complete Designs (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1967/12//
VL  - 62
IS  - 320
M3  - Book Review
SP  - 1507
SN  - 01621459
AB  - Reviews the book "Variance Analysis of Complete Designs--Some Practical Aspects," by Paul Seeger.
KW  - ANALYSIS of variance
KW  - NONFICTION
KW  - SEEGER, Paul
KW  - VARIANCE Analysis of Complete Designs (Book)
N1  - Accession Number: 4607191; Bartko, John J. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Dec67, Vol. 62 Issue 320, p1507; Thesaurus Term: ANALYSIS of variance; Subject Term: NONFICTION; Reviews & Products: VARIANCE Analysis of Complete Designs (Book); People: SEEGER, Paul; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Bolster, Mel H.
T1  - The Strategic Deployment of Exceptional Talent: An Account of the Career Executive Roster's Short History.
JO  - Public Administration Review
JF  - Public Administration Review
Y1  - 1967/12//
VL  - 27
IS  - 5
M3  - Article
SP  - 446
EP  - 451
SN  - 00333352
AB  - Early in 1961 the US Civil Service Commission established the Career Executive Roster, then a new approach to the selection and utilization of top executives in the federal career service. . . . The program was superseded by the Career Executive Inventory, a part of the US Civil Service Commission's new Executive Assignment System.
KW  - DEPLOYMENT (Military strategy)
KW  - GOVERNMENT executives
KW  - CAREER development
KW  - UNITED States -- Officials & employees -- Selection & appointment
KW  - CIVIL service
KW  - PUBLIC administration
KW  - EMPLOYEE selection
KW  - GOVERNMENT agencies
KW  - UNITED States
KW  - Career Executive Roster
KW  - Civil Service Commission
KW  - UNITED States. Civil Service Commission
N1  - Accession Number: 4600879; Bolster, Mel H. 1; Affiliations: 1 : National Institutes of Health.;  Source Info: Dec67, Vol. 27 Issue 5, p446; Historical Period: 1961 to 1966; Subject Term: DEPLOYMENT (Military strategy); Subject Term: GOVERNMENT executives; Subject Term: CAREER development; Subject Term: UNITED States -- Officials & employees -- Selection & appointment; Subject Term: CIVIL service; Subject Term: PUBLIC administration; Subject Term: EMPLOYEE selection; Subject Term: GOVERNMENT agencies; Subject: UNITED States; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - Gen
ID  - 9999-12926-000
AN  - 9999-12926-000
AU  - Waldrop, Mary F.
AU  - Pedersen, Frank A.
AU  - Bell, Richard Q.
T1  - Waldrop Anomaly Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1968///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-12926-000. Other Names: Waldrop Scale. Partial author list: First Author & Affiliation: Waldrop, Mary F.; National Institute of Mental Health, Betheda, Maryland, United States. Release Date: 20120910. Correction Date: 20160613. Instrument Type: Rating Scale. Test Format: For the 18 anomalies, scores of 0-2 are applied.. Language: English. Constructs: Minor Physical Anomalies; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). 
AB  - Purpose: The purpose of the Waldrop Anomaly Scale is to assess the incidence of minor physical anomalies.
AB  - Description: The Waldrop Anomaly Scale (Waldrop, Pederson, & Bell, 1968) was developed to assess the incidence of minor physical anomalies. The measure was constructed to enhance research relating physical anomalies and behavior in two samples of preschool children. These preschool children, who had been observed as newboms and had been considered free from complications of pregnancy and dehvery, were examined for the presence of 18 of the 21 minor physical anomalies used in the Goldfarb and Botstein (unpublished manuscript) investigation. Lack of permanent teeth, oversized incisors, and head circumference out of normal range were the 3 anomalies that the authors excluded from their list. Two examiners made independent judgments as to the existence and weight for each of the 18 minor physical defects on 10 of the 74 subjects and on 14 children from a nearby nursery school. A reliability coefficient of .70 was obtained from these two independent judgments as to the existence and weight of these 18 anomalies. The measure has also been used in a sample of schizophrenic males. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Physical Anomalies
KW  - Test Development
KW  - Waldrop Anomaly Scale
KW  - Hyperkinetic Behavior
KW  - Aggressive Behavior
KW  - Preschool Students
KW  - Schizophrenia
KW  - Minor Physical Anomalies
U5  - Waldrop Anomaly Scale [Test Development]MINOR PHYSICAL ANOMALIES AND BEHAVIOR IN PRESCHOOL CHILDREN. (AN: 1968-14315-001 from PsycINFO) WALDROP, MARY F.; PEDERSEN, FRANK A.; BELL, RICHARD Q.; 1968. Source: Child Development. 39(2), Blackwell Publishing, United Kingdom; 1968; Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Location: United States; Sample: 2 1/2-Year-Old Children Keywords: Physical Anomalies; Test Development; Waldrop Anomaly Scale; Hyperkinetic Behavior; Aggressive Behavior; Preschool Students; Subjects: Aggressive Behavior; Behavior Problems; Congenital Disorders; Hyperkinesis; Physical Appearance; Preschool Students; Rating Scales; Test Construction;
U5  - Waldrop Anomaly Scale [Test Use]The Incidence of Minor Physical Anomalies in Adult Male Schizophrenics. (AN: 2005-09727-009 from PsycINFO) Guy, James D.; Majorski, Lawrence V.; Wallace, Charles J.; Guy, Margaret P.; 1983. Source: Schizophrenia Bulletin. 9(4), National Institute of Mental Health, US; 1983; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Inpatient; Outpatient; Sample: Male Schizophrenic Inpatients  at Camarillo State Hospital and Day Treatment Patients at Harbor-UCLA Medical Center Keywords: Schizophrenia; Waldrop Anomaly Scale; Minor Physical Anomalies; Subjects: Congenital Disorders; Genetic Linkage; Physical Disfigurement; Schizophrenia;
DO  - 10.1037/t12926-000
L3  - Full; Full text; 999912926_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - GEN
AU  - Sloan, Margaret H
T1  - The relationships of medical libraries to regional medical program planning
JO  - Bulletin of the Medical Library Association
JF  - Bulletin of the Medical Library Association
Y1  - 1968/01//
VL  - 56
IS  - 1
M3  - Article
SP  - 56
EP  - 58
SN  - 00257338
AB  - Regional medical program grants will soon cover 98% of the u.s. Population and grantees are encouraged to apply for library assistance in planning for regional medical service. The community hospital learning center is an important concept in this service. Wherever a doctor takes his patients for hospitalization he should have access, through dataphone or other means, to the learning materials he needs. A hospital learning carrel would contain records, video tapes, and programmed learning materials in addition to the most used journals and textbooks. The library profession must consider what help is needed from the regional medical program in order to meet the staff and training demands that go with provision of such service.
N1  - Accession Number: ISTA0401307; Sloan, Margaret H 1; Affiliations: 1 : Regional Medical Programs, National Institutes Of Health, Bethesda, Maryland.;  Source Info: January 1968, Vol. 56 Issue 1, p56; Note: Update Code: 0400; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Drews, J.
AU  - Brawerman, G.
AU  - Morris, H. P.
T1  - Nucleotide Sequence Homologies in Nuclear and Cytoplasmic Ribonucleic Acid from Rat Liver and Hepatomas.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1968/01//
VL  - 3
IS  - 3
M3  - Article
SP  - 284
EP  - 292
SN  - 00142956
AB  - The RNA populations of rat liver and three rat hepatomas were compared by DNA-RNA hybridization studies in the presence and absence of competing RNA. The hepatoma nuclei were found to lack hybridizable RNA species present in normal liver nuclei, while the latter appeared to contain all the hepatoma RNA species. In normal liver, the cytoplasmic RNA could compete with nuclear RNA only to the extent of 20–30%. This indicates that a large number of nuclear RNA species are not transferred to the cytoplasm. In the case of the hepatomas nearly all the nuclear RNA species were detected in the cytoplasmic RNA preparations. A more extensive homology between nuclear and cytoplasmic RNA was also observed in regenerating liver. It is suggested that a selective mechanism governs the transfer of RNA species from the nucleus to the cytoplasm and that this mechanism is altered in the hepatomas. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOMOLOGY (Biology)
KW  - NUCLEOTIDE sequence
KW  - RNA
KW  - LIVER tumors
KW  - HEPATOMA
KW  - RATS as laboratory animals
N1  - Accession Number: 12768108; Drews, J. 1,2; Brawerman, G. 2,3; Morris, H. P. 2,4; Source Information: 1968, Vol. 3 Issue 3, p284; Subject: HOMOLOGY (Biology); Subject: NUCLEOTIDE sequence; Subject: RNA; Subject: LIVER tumors; Subject: HEPATOMA; Subject: RATS as laboratory animals; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - Experimental trial of selective dissemination of biomedical information in an automated system based on a linear hierarchical decimal classification
JO  - In American Society For Information Science, Proceedings, 5. Annual Meeting, October 20-24, 1968. Columbus, Ohio. P. 243-245. 1 Illus. 5 Ref. See Isa 69-010/y
JF  - In American Society For Information Science, Proceedings, 5. Annual Meeting, October 20-24, 1968. Columbus, Ohio. P. 243-245. 1 Illus. 5 Ref. See Isa 69-010/y
Y1  - 1968///
M3  - Book Chapter
AB  - The need is discussed for small-scale experimental-information systems, which provide data on the cost of the system and on the quality of selectivity of the match between user and document. As an example, a one-year trial of a linear, hierarchical, decimal classification of biomedical information for matching any one number assigned to an article against any one number assigned to a user profile is described. The operation of the system, the nature of the one-year trial, the method of evaluation, and some final results are presented.
N1  - Accession Number: ISTA0400326; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland;  Source Info: 1968; Note: Update Code: 0400; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - A computerized system based on a hierarchical decimal classification: use for selective dissemination of biomedical information (sdi)
JO  - In Ramey, James W., Ed. Fifth Annual National Colloquium On Information Retrieval; Impact Of Mechanization On Libraries And Information. Centers. 1968. Information Interscience Incorporated, Philadelphia. P. 137-143. 4 Illus. 3 Ref
JF  - In Ramey, James W., Ed. Fifth Annual National Colloquium On Information Retrieval; Impact Of Mechanization On Libraries And Information. Centers. 1968. Information Interscience Incorporated, Philadelphia. P. 137-143. 4 Illus. 3 Ref
Y1  - 1968///
M3  - Book Chapter
AB  - The use of a hierarchical decimal classification in a computerized information system is described in this paper. The initial trial is designed to test how well the system can match the information needs of scientists against the information content of published journal articles. In addition, time and effort data are collected so that the cost and performance of large-scale operations can be accurately predicted. The system is designed to operate on a realistic and economically sound basis in order to relate the results directly to real-life situations. For this reason, theoretical, artificial testing and evaluation protocols have been avoided. Instead, 103 cancer research scientists are sent summaries of published articles appearing in cancer research journals. Users rate their interest in each article, whether the article is of use, and how closely it is related to current research. Computer cost for matching document with user is less than 0.1 cent per article matched against the profile of one scientist. We have close to an 85% return of the first 3,700 evaluation slips. Of the first 2.679 replies, 24% found the summary 'very useful.' another 28% were of 'definite but limited use,' and 30% were at least 'of little or slight use.' only 18% of the summaries mailed were rated as of 'no significant use.' these figures include all the initial replies before any profile revision.
N1  - Accession Number: ISTA0600809; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland;  Source Info: 1968; Note: Update Code: 0600; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Martin, Jess A
T1  - Planning the new nih research library
JO  - Special Libraries
JF  - Special Libraries
Y1  - 1968/01//
VL  - 59
IS  - 1
M3  - Article
SP  - 30
EP  - 38
SN  - 00386723
AB  - Emphasizes the steps in planning, building, and moving into a new special library facility, including the contributions of architects, engineers, administrators, library committee members, users, professional consultants, and the library staff. Each contribution will be included in such basic documents as a program of requirements and equipment specifications. A day-by-day schedule of the projected move is appended together with a selected bibliography of new library buildings 1690-67.
N1  - Accession Number: ISTA0300476; Martin, Jess A 1; Affiliations: 1 : National Institutes Of Health, U.s. Department Of Health, Education And Welfare;  Source Info: January 1968, Vol. 59 Issue 1, p30; Note: Update Code: 0300; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2013-40697-002
AN  - 2013-40697-002
AU  - Rae-Grant, Quentin A. F.
AU  - Marcuse, Donald J.
T1  - The hazards of teamwork.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1968/01//
VL  - 38
IS  - 1
SP  - 4
EP  - 8
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40697-002. PMID: 5637332 Partial author list: First Author & Affiliation: Rae-Grant, Quentin A. F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Column/Opinion. Language: English. Major Descriptor: Hazards; Mental Health; Organizations; Work Teams. Minor Descriptor: Membership; Professional Development. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Page Count: 5. Issue Publication Date: Jan, 1968. 
AB  - The opinion article presents the hazards of teamwork. Teams, like institutions, may provide a protective mantle for their members to hide under, reducing the likelihood of direct interaction or communication with patients, who become increasingly isolated in the Kafkaesque process. The ultimate argument offered to defend the conjoint acting out of a dichotomy between the firm directive and the gentle understanding attitude is that no one person could embody both, if the situation required it. The article also illustrates a more general hazard of teamwork a hazard of team spirit. Team spirit connotes a will to win. It thrives in a context of rivalry and when a common enemy is perceived. The resulting downgrading of independent work would hurt any profession or any team or organization, but the loss in the mental health field would be uniquely crippling because of the very special and irreplaceable contribution such work offers in clinical pursuits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - team work
KW  - hazards
KW  - team members
KW  - organizations
KW  - professional development
KW  - mental health
KW  - 1968
KW  - Hazards
KW  - Mental Health
KW  - Organizations
KW  - Work Teams
KW  - Membership
KW  - Professional Development
KW  - 1968
DO  - 10.1111/j.1939-0025.1968.tb00548.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40697-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1968-09110-001
AN  - 1968-09110-001
AU  - Crane, George E.
T1  - Tardive dyskinesia in patients treated with major neuroleptics: A review of the literature.
JF  - The American Journal of Psychiatry
JO  - The American Journal of Psychiatry
JA  - Am J Psychiatry
Y1  - 1968///
VL  - 124
IS  - 8, SUPPL.
SP  - 40
EP  - 48
CY  - US
PB  - American Psychiatric Assn
SN  - 0002-953X
SN  - 1535-7228
N1  - Accession Number: 1968-09110-001. Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Crane, George E.; National Institute of Mental Health, Chevy Chase, MD, US. Release Date: 19680101. Correction Date: 20161208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Drugs; Literature Review; Nervous System Disorders; Psychiatric Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Methodology: Literature Review. Page Count: 9. Issue Publication Date: 1968. 
AB  - SINCE 1959 A GROWING NUMBER OF REPORTS HAVE DESCRIBED A NEW TYPE OF NEUROLOGICAL DISORDER IN MENTAL PATIENTS. THIS DISORDER, KNOWN AS TARDIVE DYSKINESIA, HAS BEEN OBSERVED IN APPROXIMATELY 500 CASES BUT, JUDGING FROM THE ACCURATE OBSERVATIONS MADE BY 3 SEPARATE GROUPS OF INVESTIGATORS, THE SYNDROME IS LIKELY TO BE MORE FREQUENT THAN MAY BE SUSPECTED. ALTHOUGH MANIFESTATIONS OF TARDIVE DYSKINESIA OCCUR IN A NUMBER OF DISEASES OF THE CNS, THERE IS CONSIDERABLE EVIDENCE THAT THE LARGE-SCALE USE OF PHENOTHIAZINES OR SIMILAR DRUGS IN RECENT YR. IS RESPONSIBLE FOR THE GREAT NUMBER OF PATIENTS IN MENTAL HOSPITALS EXHIBITING MYOCLONIA AND CHOREO-ATHETOID SYMPTOMS. (58 REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - TARDIVE DYSKINESIA & NEUROLEPTIC TREATMENT
KW  - REVIEW OF LITERATURE
KW  - 1968
KW  - Drug Therapy
KW  - Drugs
KW  - Literature Review
KW  - Nervous System Disorders
KW  - Psychiatric Patients
KW  - 1968
DO  - 10.1176/ajp.124.8S.40
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-09110-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40697-026
AN  - 2013-40697-026
AU  - Rae-Grant, Quentin
T1  - Review of Community and schizophrenia.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1968/01//
VL  - 38
IS  - 1
SP  - 170
EP  - 172
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40697-026. Partial author list: First Author & Affiliation: Rae-Grant, Quentin; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Community Services; Schizophrenia; Social Class; Social Processes. Minor Descriptor: Antisocial Behavior. Classification: Schizophrenia & Psychotic States (3213); Community & Social Services (3373). Population: Human (10). Reviewed Item: Dunham, H. Warren. Community and schizophrenia=Detroit: Wayne State University Press. 312 pp. $12.50; 1965. Page Count: 3. Issue Publication Date: Jan, 1968. 
AB  - Reviews the book, Community and Schizophrenia by H. Warren Dunham (see record [rid]1966-01810-000[/rid]). The book presents a comprehensive survey of methodological difficulties and a critical review of previous work and conclusions. The book provides comprehensive, detailed, and analytic review of the whole problem of epidemiology in mental health. The one part of the book examines various hypotheses regarding the relationship between community organization and social class, on the one hand, and the disease known as schizophrenia on the other. The present work raises considerable doubt that there is any causal relationship between either the type of community or social class and the incidence of schizophrenia. The book summarizes the distribution of schizophrenics in community is dependent on the process of social selection. The book is a very clear, valuable and represents the distillation of 30 years work, knowledge of the problems, and refinement of instruments and methodology, for an epidemiologists. For all serious students of deviant behavior, its individual and community origins and therefore of methods of informed intervention, it is obviously one that will become both valuable and required reading. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community services
KW  - schizophrenia
KW  - social class
KW  - deviant behavior
KW  - social processes
KW  - 1968
KW  - Community Services
KW  - Schizophrenia
KW  - Social Class
KW  - Social Processes
KW  - Antisocial Behavior
KW  - 1968
U2  - Dunham, H. Warren. (1965); Community and schizophrenia; Detroit: Wayne State University Press. 312 pp. $12.50
DO  - 10.1037/h0097557
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40697-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40697-033
AN  - 2013-40697-033
AU  - Wiener, Jack
T1  - Mental health highlights.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1968/01//
VL  - 38
IS  - 1
SP  - 182
EP  - 186
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40697-033. Partial author list: First Author & Affiliation: Wiener, Jack; Center for Studies of Mental Health and Social Problems, Applied Research Branch, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Medical Sciences; Rehabilitation; Social Services. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 5. Issue Publication Date: Jan, 1968. 
AB  - This article presents mental health highlights, which focuses on rehabilitation services, medical services, social services, community mental health services, stress and many other topics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health services
KW  - medical services
KW  - mental health highlights
KW  - rehabilitation services
KW  - social services
KW  - 1968
KW  - Community Mental Health Services
KW  - Medical Sciences
KW  - Rehabilitation
KW  - Social Services
KW  - 1968
DO  - 10.1111/j.1939-0025.1968.tb00570.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40697-033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1968-13315-001
AN  - 1968-13315-001
AU  - Essig, C. F.
T1  - Increased water consumption following forced drinking of alcohol in rats.
JF  - Psychopharmacologia
JO  - Psychopharmacologia
Y1  - 1968///
VL  - 12
IS  - 4
SP  - 333
EP  - 337
CY  - Germany
PB  - Springer
N1  - Accession Number: 1968-13315-001. PMID: 5690025 Partial author list: First Author & Affiliation: Essig, C. F.; National Institute of Mental Health, Addiction Research Center, Lexington, KY, US. Release Date: 19680101. Correction Date: 20161208. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biochemistry; Drugs; Water Deprivation; Water Intake; Water Transportation. Minor Descriptor: Alcohol Drinking Patterns; Rats; Water Safety. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 5. Issue Publication Date: 1968. 
AB  - AN ATTEMPT WAS MADE TO INDUCE PHYSICAL DEPENDENCE IN RATS BY RESTRICTING THEIR FLUID INTAKE TO CONCENTRATIONS OF ALCOHOL THAT WERE INCREASED FROM 5-20%. ALCOHOL INTAKE DECREASED DURING THE MONTH THAT THE 20% CONCENTRATION WAS AVAILABLE. FOLLOWING ALCOHOL WITHDRAWAL, WATER WAS CONSUMED IN SIGNIFICANTLY GREATER AMOUNTS THAN IN CONTROL RATS. A FLUID DEFICIT MIGHT HAVE DEVELOPED SO THAT AN INCREASE IN WATER CONSUMPTION OCCURRED WHEN IT BECAME AVAILABLE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - ALCOHOL/FORCED INGESTION OF
KW  - SUBSEQUENT INCREASE IN WATER INTAKE
KW  - RAT
KW  - 1968
KW  - Biochemistry
KW  - Drugs
KW  - Water Deprivation
KW  - Water Intake
KW  - Water Transportation
KW  - Alcohol Drinking Patterns
KW  - Rats
KW  - Water Safety
KW  - 1968
DO  - 10.1007/BF00401411
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-13315-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1968-13462-001
AN  - 1968-13462-001
AU  - Moss, Howard A.
AU  - Robson, Kenneth S.
T1  - Maternal influences in early social visual behavior.
JF  - Child Development
JO  - Child Development
JA  - Child Dev
Y1  - 1968///
VL  - 39
IS  - 2
SP  - 401
EP  - 408
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0009-3920
SN  - 1467-8624
N1  - Accession Number: 1968-13462-001. PMID: 5652768 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Moss, Howard A.; National Institute of Mental Health. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19680101. Correction Date: 20161229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Maternal Behavior; Mother Child Relations; Social Interaction; Vision. Classification: Developmental Psychology (2800). Population: Animal (20). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Page Count: 8. Issue Publication Date: 1968. 
AB  - POSITIVE ATTITUDES TOWARD INFANTS WERE ASSESSED IN 54 PRIMIPAROUS MOTHERS DURING PREGNANCY. IN SUBSEQUENT HOME OBSERVATIONS, THE FREQUENCY AT 1 AND 3 MO. OF AGE WITH WHICH MOTHER AND INFANT SIMULTANEOUSLY LOOKED AT ONE ANOTHER'S FACES (VIS-A-VIS) WAS RECORDED. AT 31/4 MO. MOST OF THESE INFANTS WERE SHOWN A SERIES OF GEOMETRIC AND SOCIAL STIMULI TO WHICH TOTAL FIXATION TIMES WERE CALCULATED. FOR FEMALE INFANTS THE PREGNANCY RATINGS, VIS-A-VIS SCORES, AND TOTAL FIXATION TIMES TO SOCIAL STIMULI WERE ALL POSITIVELY INTERCORRELATED. HOWEVER, FOR MALES THE PREGNANCY RATINGS WERE SIGNIFICANTLY ASSOCIATED ONLY WITH THE 1-MO SCORE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - SOCIAL VISUAL BEHAVIOR & MATERNAL INFLUENCE
KW  - SEX DIFFERENCES
KW  - 1-3 MO. OLD INFANTS
KW  - 1968
KW  - Animal Maternal Behavior
KW  - Mother Child Relations
KW  - Social Interaction
KW  - Vision
KW  - 1968
DO  - 10.2307/1126954
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-13462-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1968-08510-001
AN  - 1968-08510-001
AU  - Meltzer, Herbert
T1  - Creatine kinase and aldolase in serum: Abnormality common to acute psychoses.
JF  - Science
JO  - Science
JA  - Science
Y1  - 1968///
VL  - 159
IS  - 3821
SP  - 1368
EP  - 1370
CY  - US
PB  - American Assn for the Advancement of Science
SN  - 0036-8075
N1  - Accession Number: 1968-08510-001. PMID: 5644267 Partial author list: First Author & Affiliation: Meltzer, Herbert; National Institutes of Health, Bethesda, MD, US. Release Date: 19680101. Correction Date: 20161205. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biochemistry; Drugs; Psychosis. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Page Count: 3. Issue Publication Date: 1968. 
AB  - ACTIVITY OF CREATINE KINASE AND ALDOLASE IN SERUM INCREASED IN 14 OF 16 PATIENTS WITH RECENT ONSET OF A PSYCHOTIC REACTION, AND IN 5 OF 6 PATIENTS TREATED WITH PSYCHOTOMIMETIC DRUGS. THERE WAS EITHER NO INCREASE OF THESE ENZYMES OR A SLIGHT INCREASE IN SEVERELY AGITATED (OR DEPRESSED) NONPSYCHOTIC HOSPITALIZED PATIENTS AND CHRONIC PSYCHOTIC PATIENTS. THE INCREASE OF THE ENZYMES PRECEDED THE ONSET OF THE ACUTE PSYCHOTIC SYMPTOMS IN AT LEAST 3 CASES, WAS HIGHEST DURING THE 1ST 2 WK. OF A PSYCHOTIC EPISODE, AND SOMETIMES RECURRED THROUGHOUT THE ILLNESS, PARTICULARLY AT TIMES OF STRESS. THE CREATINE KINASE IN THE SERUM IS PRIMARILY OF THE MUSCLE TYPE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CREATINE KINASE & ALDOLASE
KW  - PSYCHOTOMIMETIC DRUGS
KW  - PSYCHOTICS
KW  - 1968
KW  - Biochemistry
KW  - Drugs
KW  - Psychosis
KW  - 1968
DO  - 10.1126/science.159.3821.1368
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-08510-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Ward, Charles D.
AU  - Barrett, James E.
T1  - THE ECUMENICAL COUNCIL AND ATTITUDE CHANGE AMONG CATHOLIC, PROTESTANT, AND JEWISH COLLEGE STUDENTS.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1968/02//
VL  - 74
IS  - 1
M3  - Article
SP  - 91
EP  - 96
SN  - 00224545
AB  - A total of 219 subjects of differing religions were given attitude questionnaires at the beginning and conclusion of the fourth meeting of the Vatican Ecumenical Council. A supplementary sample of 107 subjects completed the same questionnaire some five months after the Council had adjourned. It was found that Catholics became more favorable toward birth control, and more so than did Protestants or Jews. At the beginning of the Council's meeting Catholics were slightly more anti-Semitic than Protestants, but five months after the Council's adjournment the Catholics were lower in anti-Semitism than were the Protestants, although not significantly so. No sizeable differences in attitudes were found on the Negro and religious intermarriage issues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Social Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ATTITUDE change (Psychology)
KW  - COLLEGE students
KW  - CATHOLICS
KW  - ATTITUDE (Psychology)
KW  - PROTESTANTS
KW  - QUESTIONNAIRES
KW  - DECISION MAKING AND COMMUNICATIONS
KW  - Patterns of opinion spread and opinion change
KW  - Racial and ethnic aspects of tension
N1  - Accession Number: 16489225; Ward, Charles D. 1; Barrett, James E. 2; Affiliations: 1 : Department of Psychology, University of Maryland.; 2 : National Institutes of Health.;  Source Info: Feb1968, Vol. 74 Issue 1, p91; Subject Term: ATTITUDE change (Psychology); Subject Term: COLLEGE students; Subject Term: CATHOLICS; Subject Term: ATTITUDE (Psychology); Subject Term: PROTESTANTS; Subject Term: QUESTIONNAIRES; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Patterns of opinion spread and opinion change; Author-Supplied Keyword: Racial and ethnic aspects of tension; Number of Pages: 6p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=24h&AN=16489225&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - 24h
ER  - 

TY  - JOUR
ID  - 2005-09872-001
AN  - 2005-09872-001
AU  - Katz, Martin M.
AU  - Waskow, Irene E.
AU  - Olsson, James
T1  - Characterizing the psychological state produced by LSD.
JF  - Journal of Abnormal Psychology
JO  - Journal of Abnormal Psychology
JA  - J Abnorm Psychol
Y1  - 1968/02//
VL  - 73
IS  - 1
SP  - 1
EP  - 14
CY  - US
PB  - American Psychological Association
SN  - 0021-843X
SN  - 1939-1846
N1  - Accession Number: 2005-09872-001. PMID: 5639999 Other Journal Title: The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Katz, Martin M.; Psychopharmacology Research Branch, National Institutes of Health, Bethesda, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Meetings of the Collegium Internationale Neuropsychopharmacologicum, Mar, 1966, Washington, DC, US. Conference Note: Based on a paper presented at the aforementioned meetings. Major Descriptor: Amphetamine; Emotions; Lysergic Acid Diethylamide; Psychopharmacology. Minor Descriptor: Male Criminals; Prisoners; Verbal Communication; Vocalization. Classification: Psychopharmacology (2580). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Subjective Drug Effects Questionnaire; Picture Rating Technique. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Feb, 1968. Copyright Statement: American Psychological Association. 1968. 
AB  - Two studies, involving 69 male inmates of an experimental penal institution, investigated the psychological states produced by LSD as compared with amphetamine and placebo controls. A number of scales on a newly developed subjective drug-effects questionnaire significantly differentiated the groups. This instrument was further used to identify 3 qualitatively different subjective states produced by LSD (moderately euphoric, dysphoric, and ambivalent). New techniques for exploring the perceptual and vocal components of emotional change were also applied. These techniques further elucidated the quality and possible origin of the psychological states produced by LSD. The results (which indicate the presence of highly intense but contradictory emotions) were interpreted in the light of a current theory of emotion and Bartlett's concept of 'effort after meaning.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological states
KW  - LSD
KW  - amphetamines
KW  - drug effects
KW  - verbal behavior
KW  - vocal behavior
KW  - emotions
KW  - male inmates
KW  - 1968
KW  - Amphetamine
KW  - Emotions
KW  - Lysergic Acid Diethylamide
KW  - Psychopharmacology
KW  - Male Criminals
KW  - Prisoners
KW  - Verbal Communication
KW  - Vocalization
KW  - 1968
DO  - 10.1037/h0020114
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09872-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1968-08747-001
AN  - 1968-08747-001
AU  - Bell, Richard Q.
T1  - A reinterpretation of the direction of effects in studies of socialization.
JF  - Psychological Review
JO  - Psychological Review
JA  - Psychol Rev
Y1  - 1968/03//
VL  - 75
IS  - 2
SP  - 81
EP  - 95
CY  - US
PB  - American Psychological Association
SN  - 0033-295X
SN  - 1939-1471
N1  - Accession Number: 1968-08747-001. PMID: 4870552 Partial author list: First Author & Affiliation: Bell, Richard Q.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 19680101. Correction Date: 20161205. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Parent Child Relations; Socialization. Classification: Developmental Psychology (2800); Social Psychology (3000). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 15. Issue Publication Date: Mar, 1968. Copyright Statement: American Psychological Association. 1968. 
AB  - STUDIES ARE SUMMARIZED INDICATING THAT THE BASIC MODEL OF SOCIALIZATION, THE ACTION OF A PARENT ON A CHILD, IS TOO LIMITED TO ACCOMMODATE DATA EMERGING FROM RECENT STUDIES OF HUMAN AND ANIMAL SS. A SET OF PROPOSITIONS IS PRESENTED CONCERNING THE EFFECTS OF CONGENITAL FACTORS IN CHILDREN ON PARENT BEHAVIOR. THIS SYSTEM IS APPLIED TO CURRENT FINDINGS IN SEVERAL MAJOR AREAS. CURRENT LITERATURE ON SOCIALIZATION, BASED LARGELY ON CORRELATIONS BETWEEN PARENT AND CHILD BEHAVIOR, CAN BE REINTERPRETED PLAUSIBLY AS INDICATING EFFECTS OF CHILDREN ON PARENTS. A CORRELATION DOES NOT INDICATE DIRECTION OF EFFECT. IT IS FELT THAT THE EFFECT OF CHILDREN ON PARENTS CAN NO LONGER BE DISMISSED AS ONLY A LOGICAL BUT IMPLAUSIBLE ALTERNATIVE EXPLANATION OF A CORRELATION. (2 P. REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CHILDREN ON PARENTS/EFFECT OF
KW  - 1968
KW  - Parent Child Relations
KW  - Socialization
KW  - 1968
DO  - 10.1037/h0025583
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-08747-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - GEN
AU  - Purdy, Marie E
AU  - Schless, Arthur P
AU  - Stevenson, Robert E
T1  - Reading guide and index to the cancervirology literature
JO  - American Documentation
JF  - American Documentation
Y1  - 1968/04//
VL  - 19
IS  - 2
M3  - Article
SP  - 163
EP  - 167
SN  - 0096946X
AB  - An alerting service to the pertinent articles in the field of cancer-virology has been in operation, successfully, for four years. By cooperative efforts, approximately 200 investigators are kept aware of useful information in 230 journals. Its low cost, ease of operation and extensive up-to-date coverage make it an attractive model for many other applications. An information retrieval addition to this system is discussed.
N1  - Accession Number: ISTA0301266; Purdy, Marie E 1; Schless, Arthur P; Stevenson, Robert E; Affiliations: 1 : National Cancer Institute.;  Source Info: April 1968, Vol. 19 Issue 2, p163; Note: Update Code: 0300; Number of Pages: 5p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0301266&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Schless, Arthur P.
AU  - Purdy, Marie E.
AU  - Stevenson, Robert E.
T1  - Reading Guide and Index to the Cancer-Virology Literature.
JO  - American Documentation
JF  - American Documentation
Y1  - 1968/04//
VL  - 19
IS  - 2
M3  - Article
SP  - 163
EP  - 167
SN  - 0096946X
AB  - An alerting service to the pertinent articles in the field of cancer-virology has been in operation, successfully, for four years. By cooperative efforts, approximately 200 investigators are kept aware of useful information in 230 journals. Its low cost, ease of operation, and extensive up-to-date coverage make it an attractive model for many other applications. An information retrieval addition to this system is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Documentation is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INFORMATION retrieval
KW  - INFORMATION storage & retrieval systems
KW  - INFORMATION resources management
KW  - CANCER
KW  - VIROLOGY
KW  - PERIODICALS
N1  - Accession Number: 16864590; Schless, Arthur P. 1; Purdy, Marie E. 1; Stevenson, Robert E. 1; Affiliations: 1: Viral Carcinogenesis Branch National Cancer Institute Bethesda, Maryland.; Issue Info: Apr1968, Vol. 19 Issue 2, p163; Thesaurus Term: INFORMATION retrieval; Thesaurus Term: INFORMATION storage & retrieval systems; Thesaurus Term: INFORMATION resources management; Subject Term: CANCER; Subject Term: VIROLOGY; Subject Term: PERIODICALS; NAICS/Industry Codes: 519190 All Other Information Services; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 451310 Book stores and news dealers; Number of Pages: 5p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16864590&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2013-40690-026
AN  - 2013-40690-026
AU  - Yarrow, Leon J.
AU  - Pedersen, Frank A.
T1  - Review of Determinants of infant behavior, III.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1968/04//
VL  - 38
IS  - 3
SP  - 571
EP  - 573
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40690-026. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Animal Maternal Behavior; Infant Development; Mother Child Relations. Minor Descriptor: Home Environment; Kibbutz; Rats. Classification: Social & Instinctive Behavior (2440). Population: Human (10); Animal (20); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Reviewed Item: Foss, B. M. (Ed). Determinants of infant behavior, III=New York: John Wiley & Sons, 264 pp; 1965. Page Count: 3. Issue Publication Date: Apr, 1968. 
AB  - Reviews the book, Determinants of Infant Behavior, III edited by B. M. Foss (see record [rid]1966-07541-000[/rid]). This report of the third seminar on Mother-Infant Interaction reflects a major shift during the past decade towards direct observation of mothers and infants in natural settings, and toward differentiated analyses of mother-infant interactions. The papers reflect this diversity around a common theme by the varied points of view. A study of how the characteristics of the offspring affect the maternal behavior cycle in rats points to the infant's role in maintaining basic maternal behavior patterns. Another study of diverse childrearing environments in Israel, made detailed observations throughout the entire day of children and caretakers. Some papers suggests that there may be an overemphasis on constitutional differences as determinants of the infant's earliest interactions with the mother. A study of twins in early infancy found evidence suggesting a genetic basis for the development of positive social orientation and fear of strangers. Other interesting reports included in this volume focus on Kibbutz and family environment; a classification scheme for systematic analysis of interaction patterns. The book reflects the current state of this research area: many important issues are illuminated, but few are resolved. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - infant behavior
KW  - mother infant interaction
KW  - rats
KW  - maternal behavior
KW  - Kibbutz
KW  - family environment
KW  - 1968
KW  - Animal Maternal Behavior
KW  - Infant Development
KW  - Mother Child Relations
KW  - Home Environment
KW  - Kibbutz
KW  - Rats
KW  - 1968
U2  - Foss, B. M. (Ed). (1965); Determinants of infant behavior, III; New York: John Wiley & Sons, 264 pp
DO  - 10.1037/h0097148
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40690-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Draper, L.R.
AU  - Hirata, A.A.
T1  - Antibody Responses in Rabbits to Soluble and Particulate Forms of Bovine Serum Albumin.
JO  - Immunology
JF  - Immunology
Y1  - 1968/07//
VL  - 15
IS  - 1
M3  - Article
SP  - 23
EP  - 30
SN  - 00192805
AB  - Antibody responses to an insoluble derivative of bovine serum albumin (IBSA) and to its corresponding soluble form (SBSA) were compared in rabbits. The two antigens could not be distinguished serologically. Less IBSA than SBSA was required to induce a detectable primary response. At higher doses, 10-20 mg/kg, IBSA evoked more prompt primary and secondary responses than SBSA but peak litres were sometimes higher in the SBSA group. After secondary injections, serum antibody litre persisted for at least 18 months in most rabbits. Early in the primary response to either form of antigen a substantial proportion of the serum antibody was of the 19S type. The shift to 7S production occurred abruptly and early after IBSA injection but it was gradual after SBSA injection, which suggested a relatively prolonged period of induction in the latter case. 75 antibody predominated during the secondary response to both antigens although the proportion of 1 9S antibody increased somewhat 4 weeks after the reinjection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - GLOBULINS
KW  - ANTIGENS
KW  - PLASMA cells
KW  - IMMUNITY
KW  - IMMUNOLOGY
N1  - Accession Number: 13346171; Draper, L.R. 1; Hirata, A.A. 1; Source Information: Jul68, Vol. 15 Issue 1, p23; Subject: IMMUNOGLOBULINS; Subject: GLOBULINS; Subject: ANTIGENS; Subject: PLASMA cells; Subject: IMMUNITY; Subject: IMMUNOLOGY; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2005-10454-003
AN  - 2005-10454-003
AU  - Shakow, David
T1  - Apology.
JF  - American Psychologist
JO  - American Psychologist
JA  - Am Psychol
Y1  - 1968/07//
VL  - 23
IS  - 7
SP  - 535
EP  - 535
CY  - US
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
N1  - Accession Number: 2005-10454-003. Partial author list: First Author & Affiliation: Shakow, David; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060327. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Erratum/Correction. Language: English. Major Descriptor: Frustration; Government; Null Hypothesis Testing; Occupations; Personnel. Minor Descriptor: Apology. Classification: Industrial & Organizational Psychology (3600). Page Count: 1. Issue Publication Date: Jul, 1968. Copyright Statement: American Psychological Association. 1968. 
AB  - Reports an error in the original article by D. Shakow (American Psychologist, 1968, 23, pp. 87-96). I am mortified to have overdone the l's in my article, 'On the Rewards (and, Alas, Frustrations) of Public Service'. It was not General Stillwell who was responsible for illegitimati non carborundum, but General Stilwell. Fortunately, one of the proper Stilwells of psychology was around to bring me into line. I apologize to all the 'single-elled' Stilwells. (The following abstract of this article originally appeared in record [rid]1968-09533-001[/rid].) Urges that government support also extend to creative work and individuality as government operations expand. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - employment
KW  - rewards
KW  - frustrations
KW  - 1968
KW  - Frustration
KW  - Government
KW  - Null Hypothesis Testing
KW  - Occupations
KW  - Personnel
KW  - Apology
KW  - 1968
DO  - 10.1037/h0020805
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10454-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40689-017
AN  - 2013-40689-017
AU  - Kramer, Martin A.
T1  - Responsible systems of care for community mental health centers.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1968/07//
VL  - 38
IS  - 4
SP  - 700
EP  - 704
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40689-017. PMID: 5661554 Partial author list: First Author & Affiliation: Kramer, Martin A.; Mental Health Facilities Branch, Division of Mental Health Service Programs, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1967, Washington, DC, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Community Mental Health; Community Mental Health Centers; Mental Health Services. Minor Descriptor: Goals. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 5. Issue Publication Date: Jul, 1968. 
AB  - Current conceptual models for the delivery of mental health services lead us to lose sight of certain aspects of our ultimate goal while emphasizing others. As with all conceptual models, they tend to pass unquestioned. This paper reexamines the unstated premises of three such models. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health
KW  - conceptual models
KW  - mental health centers
KW  - mental health services
KW  - ultimate goals
KW  - 1968
KW  - Community Mental Health
KW  - Community Mental Health Centers
KW  - Mental Health Services
KW  - Goals
KW  - 1968
DO  - 10.1111/j.1939-0025.1968.tb02440.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Bowen, W. J.
AU  - Evans Jr., T. C.
T1  - The Binding of ATP to Myosins B and A.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1968/09//
VL  - 5
IS  - 4
M3  - Article
SP  - 507
EP  - 512
SN  - 00142956
AB  - Values for binding of ATP and ADP to myosin B and ATP to myosin A were determined from mixtures of these nucleotides and proteins by use of rapid filtration to separate bound and unbound nucleotides and by use of an ATP-regenerating system (ereatine phosphate­creatine phosphokinase). Calculation of the binding curves of ATP to 105 g of myosin B by the mass law binding expression using two sets of binding sites, n1 and n2, and with binding constants, k1=40 × 103 and k2=1.5 × 103 1/mole, respectively, yielded a curve of good fit to the experimentally determined points when n1=0.4 and n2=1.2 moles per l05 g. Similar calculation of data from binding of ATP to myosin A fielded a curve of best fit when n1=0.5 and n2=3.0 per 105 g with k1=5,500 and k2=550 1/mole. At 1 mM ATP, myosin A bound 50% more than myosin B. ADP at 1 mM appeared to saturate myosin B about 97%. The amounts of ADP bound to myosin B fitted a curve with one value of n which equaled 0.36. Multiplication of 105 g by the factors required to convert the above n values to integers fields combining weights of 250,000 and 200,000 for myosin B and myosin A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADENOSINE triphosphate
KW  - MYOSIN
KW  - NUCLEOTIDES
KW  - PROTEINS
KW  - BIOCHEMISTRY
KW  - CREATINE
N1  - Accession Number: 12791312; Bowen, W. J. 1,2; Evans Jr., T. C. 1,3; Source Information: 1968, Vol. 5 Issue 4, p507; Subject: ADENOSINE triphosphate; Subject: MYOSIN; Subject: NUCLEOTIDES; Subject: PROTEINS; Subject: BIOCHEMISTRY; Subject: CREATINE; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Colten, H. R.
AU  - Silverstein, A. M.
AU  - Bonos, T.
AU  - Rapp, H. J.
T1  - Ontogeny of the First Component of Sheep Complement.
JO  - Immunology
JF  - Immunology
Y1  - 1968/09//
VL  - 15
IS  - 3
M3  - Article
SP  - 459
EP  - 461
SN  - 00192805
AB  - Discusses a study on the appearance of hemolytic complement activity in the sera of embryonic sheep. Whole complement activity in sera of fetal lambs discovered after the 123rd day of gestation; Description of the hemolytic C activity which depends on the presence of all the C components in the serum; Insensitivity of titres of hemolytic C to large variations in the concentration of some of the components.
KW  - SHEEP
KW  - LIVESTOCK
KW  - HEMOLYSIS & hemolysins
KW  - IMMUNITY
KW  - BLOOD
KW  - ANTIGEN-antibody reactions
N1  - Accession Number: 13347662; Colten, H. R. 1; Silverstein, A. M. 1; Bonos, T. 1; Rapp, H. J. 1; Source Information: Sep68, Vol. 15 Issue 3, p459; Subject: SHEEP; Subject: LIVESTOCK; Subject: HEMOLYSIS & hemolysins; Subject: IMMUNITY; Subject: BLOOD; Subject: ANTIGEN-antibody reactions; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Bering, Edgar A, Jr
T1  - Critical reviews: the sponsor's point of view
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1968/11//
VL  - 8
IS  - 4
M3  - Article
SP  - 236
EP  - 237
SN  - 00219576
AB  - The major items which the sponsor of critical reviews must consider include: (1) the audience for whom the review is produced, (2) the selection of the subject and the scope of the review, (3) the method of production of a review, and (4) distribution of the completed product. The audience any given sponsor serves will, to some degree, determine the subject and scope of the reviews he might sponsor. The general methods of production are the single individual, special workshop, or large symposium. The distribution can be done by one of several methods, but will probably be dictated by the audience and the resources available.
N1  - Accession Number: ISTA0401312; Bering, Edgar A, Jr 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: November 1968, Vol. 8 Issue 4, p236; Note: Update Code: 0400; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Gart, John J.
T1  - Statistics for Biologists (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1968/12//
VL  - 63
IS  - 324
M3  - Book Review
SP  - 1540
SN  - 01621459
AB  - Reviews the book "Statistics for Biologists," by R.C. Campbell.
KW  - STATISTICS
KW  - NONFICTION
KW  - CAMPBELL, R. C.
KW  - STATISTICS for Biologists (Book)
N1  - Accession Number: 4608253; Gart, John J. 1; Affiliations: 1: National Cancer Institute; Issue Info: Dec68, Vol. 63 Issue 324, p1540; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: STATISTICS for Biologists (Book); People: CAMPBELL, R. C.; Number of Pages: 2/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Oppenheim, J. J.
AU  - Rogentine, G. N.
AU  - Terry, W. D.
T1  - The Transformation of Human Lymphocytes by Monkey Antisera to Human Immunoglobulins.
JO  - Immunology
JF  - Immunology
Y1  - 1969/01//
VL  - 16
IS  - 1
M3  - Article
SP  - 123
EP  - 138
SN  - 00192805
AB  - Cultures of human peripheral leucocytes were stimulated to incorporate tritiated thymidine when incubated with monkey antisera to human immunoglobulins. Twenty-five of forty-four monkey antisera were active and stimulated 90 per cent of leucocyte (WBC) cultures to incorporate a small but significantly greater amount of tritiated thymidine (TdR3H) than that incorporated by controls. This stimulation of TdR3H uptake correlated with an increase from 2 to 8 per cent lymphoblasts in the cultures. Leucocytes washed free of serum immunoglobulins responded to a greater degree to the anti-immunoglobulin sera than when they were cultured in the presence of human serum. Prior absorption of antisera with either whole serum or homologous immunoglobulin blocked anti-serum stimulation completely. The anti-IgG and anti-IgM antisera were consistently more effective than anti-IgA, anti-K and anti-A chain antisera. Sequential stimulation by antisera against two different immunoglobulins was not significantly different from those stimulated by only one of the two, Lymphocytes from three asymptomatic subjects with low or absent serum IgA levels transformed as well with anti-IgA as did lymphocytes from subjects with normal serum IgA levels. Antisera were cytotoxic to the lymphocytes only in the presence of complement. Presumably the transformation of human lymphocytes was due to a reaction of anti-immunoglobulin antisera with specific immunoglobulin antigenic determinants present on or in the circulating lymphocytes.
KW  - LEUCOCYTES
KW  - IMMUNE serums
KW  - IMMUNOGLOBULINS
KW  - BLOOD cells
KW  - LYMPHOCYTES
KW  - IMMUNOLOGY
N1  - Accession Number: 13350488; Oppenheim, J. J. 1; Rogentine, G. N. 1; Terry, W. D. 1; Source Information: Jan69, Vol. 16 Issue 1, p123; Subject: LEUCOCYTES; Subject: IMMUNE serums; Subject: IMMUNOGLOBULINS; Subject: BLOOD cells; Subject: LYMPHOCYTES; Subject: IMMUNOLOGY; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Caponio, Joseph F
T1  - Ninds neurological information network
JO  - In North, Jeanne B., Ed. Proceedings Of The American Society For Information Science. Volume 6. 32nd Annual Meeting, San Francisco, California, October 1-4, 1969. 1969. Greenwood Publishing Corporation, Westport, Conn.; London, England. P. 447-452. 0 Ref
JF  - In North, Jeanne B., Ed. Proceedings Of The American Society For Information Science. Volume 6. 32nd Annual Meeting, San Francisco, California, October 1-4, 1969. 1969. Greenwood Publishing Corporation, Westport, Conn.; London, England. P. 447-452. 0 Ref
Y1  - 1969///
M3  - Book
AB  - This paper describes the neurological information network supported by the national institute of neurological diseases and stroke. The network is composed of the following four centers: the parkinson information center; the brian information service; the information center for hearing, speech and disorders of human communication; and the vision information center. The work of the centers is coordinated by a committee which also serves as the focal point for interaction. The ninds information network is dedicated to the following objectives: 1) acquisition, screening, abstracting, indexing and compliation of current citations; 2) preparing state-of-the-art reports, cirtical reviews, and exhibits; 3) sponsoring and conducting ad hoc workshops and symposia; and 4) answering requests for specific information on neuro-sensory diseases.
N1  - Accession Number: ISTA0401954; Caponio, Joseph F 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1969; Note: Update Code: 0400; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - Design of a comprehensive information system based on linear hierarchical decimal classifications
JO  - In Schultz. Louise, Ed. Proceedings Of The Sixth Annual National Colloquium On Information Retrieval. 1969. Medical Documentation Service, College Of Physicians, Philadelphia. P. 99-105. 8 Ref
JF  - In Schultz. Louise, Ed. Proceedings Of The Sixth Annual National Colloquium On Information Retrieval. 1969. Medical Documentation Service, College Of Physicians, Philadelphia. P. 99-105. 8 Ref
Y1  - 1969///
M3  - Book Chapter
AB  - After stating the advantages of using classifications rather than thesauri as the basis for modern retrieval systems, this paper describes a single-hit method of matching users against documents. The value of a single-hit matching for classification-based selective dissemination of biomedical information (s.d.i.) has been demonstrated. Use of the classification for retrospective retrieval, for on-line searching by users, and for preparation of indexes, current-awareness bulletins, and bibliographies, is proposed. Types of files and operations required for a comprehensive classification-based information system are identified. A pl/1 program has been written which uses an ibm 360/50 system for automated updating and maintenance of linear hierarchical classifications.
N1  - Accession Number: ISTA0600781; Schneider, John H 1; Affiliations: 1 : National Cancer Institute;  Source Info: 1969; Note: Update Code: 0600; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Marshall, J. R.;
AU  - Jacobson, A.;
AU  - Hammond, C. B.;
T1  - Dose response relationships of ovulation induction with human menopausal gonadotropin (HMG)
CT  - Dose response relationships of ovulation induction with human menopausal gonadotropin (HMG)
JO  - J. Clin. Endocrinol. Metab.
JF  - J. Clin. Endocrinol. Metab.
Y1  - 1969/01/01/
VL  - 29
IS  - Jan
SP  - 106
EP  - 110
AD  - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-0269; Language: English; References: 9; Journal Coden: JCEMAZ; Section Heading: Pharmacology
N2  - The relationship between dose of HMG and induction of ovulation has been studied during 178 cycles in 29 anovulatory or oligo-ovulatory women. HMG was started at subovulatory doses and increased in subsequent cycles until ovulation resulted. The first HMG dose causing ovulation was called the first ovulatory dose. The ratio of the actual dose used to the first ovulatory dose was called the relative dose. Subovulatory responses were rated for estrogen effect according to cervical mucus response. Ovulation was determined by BBT, clinical response, urinary pregnanediols and endometrial biopsy. Ovarian size was estimated by pelvic examination. Ovulation was induced in 82 cycles in 28 women. Thirteen patients conceived; one set of twins was the only multiple pregnancy. Absolute HMG dose was positively related to subovulatory response. Examination of response as a function of relative dose significantly decreased variability. Relative dose was positively related to subovulatory response, ovulatory response rate and ovarian enlargement rate. Oligo-ovulatory patients had lower thresholds to HMG than did anovulatory patients; however, sensitivity was not different. Ovulatory rate was independent of duration of therapy or response in preceding cycles and was stable at a rate determined by HMG dose. Results demonstrate the consistency of response to gonadotropins and provide a basis for minimizing hazards of therapy.
KW  - Gonadotropins--human menopausal--relationship between dose and induction of ovulation;
KW  - Dosage--gonadotropins--human menopausal, relationship to ovulation induction;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Feeley, J. C.;
AU  - Roberts, C. O.;
T1  - Immunological responses of laboratory animals to cholera vaccines, toxin and toxoid
CT  - Immunological responses of laboratory animals to cholera vaccines, toxin and toxoid
JO  - Tex. Rep. Biol. Med.
JF  - Tex. Rep. Biol. Med.
Y1  - 1969/01/01/
VL  - 27
IS  - Suppl 1
SP  - 213
EP  - 226
AD  - Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3922; Language: English; References: 37; Journal Coden: TRBMAY; Section Heading: Pharmacology; Microbiology; Abstract Author: Harvey A. K. Whitney, Jr.
N2  - The capabilities of conventional cholera vaccine and experimental vaccines, toxins and toxoids to induce antibody against the permeability factor (PF) toxin of Vibrio cholera were examined in guinea pigs and rabbits. Vaccines from 4 U. S. licensed manufacturers were assayed by the mouse protection test and were used to immunize guinea pigs. The animals were skin tested with graded doses of PF toxin. Rabbits were hyperimmunized with 3 of the vaccines. Crude Syncase toxin filtrate was converted to toxoid by 2 methods and used to immunize guinea pigs. With the exception of recent lots of vaccine produced by a single manufacturer, conventional cholera vaccines are lacking in detectable PF toxin and do not seem capable of stimulating an antitoxic response against this antigen in guinea pigs or rabbits. Experimental living and formalinized whole-cell vaccines and supernatants from these vaccines were capable of inducing antitoxin and dermal resistance to PF toxin. Toxoids were 3-5 times more antigenic in stimulating antitoxin than the parent toxin. The possible significance of the toxin antigen in formulating a more effective cholera vaccine for immunization was discussed.
KW  - Cholera vaccines--antibody induction-;
KW  - Immunology--immunological response--antibody induction, against permeability factor toxin of Vibrio cholera, in animals;
KW  - Vaccines--immunological responses--induce antibody against permeability factor toxin of Vibrio cholera, in animals;
KW  - Toxins--antibody induction--against permeability factor toxin of Vibrio cholera;
KW  - Toxoids--antibody induction--against permeability factor toxin of Vibrio cholera;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-40702-024
AN  - 2013-40702-024
AU  - Wiener, Jack
T1  - Mental health highlights.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1969/01//
VL  - 39
IS  - 1
SP  - 146
EP  - 149
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40702-024. Partial author list: First Author & Affiliation: Wiener, Jack; Center for Studies of Mental Health and Social Problems, Applied Research Branch, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health; Rehabilitation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1969. 
AB  - This article present mental health highlights, which focuses on Education Assistance Act, Rehabilitation Amendments, Juvenile Delinquency Prevention and Control Act, Health Manpower Act, new cure for hysteria and many more topics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health highlights
KW  - education assistance
KW  - rehabilitation amendments
KW  - health manpower
KW  - 1969
KW  - Mental Health
KW  - Rehabilitation
KW  - 1969
DO  - 10.1111/j.1939-0025.1969.tb00629.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Foley, T. H.;
AU  - Bennett, J. M.;
AU  - Carbone, P. P.;
T1  - Combination chemotherapy in accelerated phase of chronic granulocytic leukemia
CT  - Combination chemotherapy in accelerated phase of chronic granulocytic leukemia
JO  - Archives of Internal Medicine (USA)
JF  - Archives of Internal Medicine (USA)
Y1  - 1969/02/01/
VL  - 123
IS  - Feb
SP  - 166
EP  - 172
SN  - 00039926
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-1141; Language: English; Chemical Name: Prednisone--53-03-2 Methotrexate--59-05-2 Mercaptopurine--6112-76-1 Vincristine--57-22-7; References: 8; Journal Coden: AIMDAP; Section Heading: Drug Evaluations; Abstract Author: Zina Fediay
N2  - With the demonstration of the efficacy of combination chemotherapy in acute leukemia, both lymphocytic and granulocytic, a study was undertaken to assess the value of such therapy in blast crisis. Thirteen patients, 16 to 68 years of age, with chronic granulocytic leukemia, were treated with prednisone, methotrexate, and mercaptopurine. Vincristine sulfate was added to the regimen for 5 patients. All drugs were given intravenously daily for 5 consecutive days. Only one complete clinical remission was seen and there were 2 partial remissions. The toxicity was severe and included 4 drug-related deaths.
KW  - Prednisone--leukemia-;
KW  - Methotrexate--leukemia-;
KW  - Mercaptopurine--leukemia-;
KW  - Vincristine--sulfate-;
KW  - Drugs--combined therapy--in accelerated phase of chronic granulocytic leukemia;
KW  - Antineoplastic agents--combined therapy--in accelerated phase of chronic granulocytic leukemia;
KW  - Toxicity--antineoplastic agents--combined therapy, in accelerated phase of chronic granulocytic leukemia;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - King, Kaitung
AU  - Bailar III, John C.
T1  - THE HEALTH OF THE CLERGY: A REVIEW OF DEMOGRAPHIC LITERATURE.
JO  - Demography
JF  - Demography
Y1  - 1969/02//
VL  - 6
IS  - 1
M3  - Article
SP  - 27
EP  - 43
SN  - 00703370
AB  - A combination of special studies and official statistics permits an evaluation of the health of the clergy over the past century. The mortality experience of clergymen has been consistently more favorable than that of the general male population. It also has been favorable in comparison with the experience of men in the legal and medical professions although this differential has been diminishing. The initially favorable position of the clergy relative to teachers has been reversed. There is some evidence of mortality differentials within the clerical profession by major faith, denomination, or ministerial specialty. Clergymen have a relatively high mortality rate from cardiovascular- renal diseases and malignancies, but a very low rate for non-degenerative diseases and suicide. Morbidity statistics for the clergy are fragmentary. They may be over-represented among persons hospitalized for conditions that are emotional in origin. The clergy has some special advantages for studies of health, primarily that both membership in the study population and mortality can be determined with comparative ease. Several areas of future research are suggested. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEMOGRAPHY
KW  - STATISTICS
KW  - MORTALITY
KW  - CLERGY
KW  - POPULATION
KW  - DISEASES
N1  - Accession Number: 16798812; King, Kaitung 1; Bailar III, John C. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014, and Department of Community Medicine and International Health, Georgetown University Medical School, Washington, D.C. 20007.; 2: National Cancer Institute, Bethesda, Maryland 20014.; Issue Info: Feb1969, Vol. 6 Issue 1, p27; Thesaurus Term: DEMOGRAPHY; Thesaurus Term: STATISTICS; Subject Term: MORTALITY; Subject Term: CLERGY; Subject Term: POPULATION; Subject Term: DISEASES; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - GEN
AU  - Bever, Arley T
T1  - The duality of quick and archival communication
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1969/02//
VL  - 9
IS  - 1
M3  - Article
SP  - 3
EP  - 6
SN  - 00219576
AB  - The relative strengths and weaknesses are discussed of formalized, centralized preprint exchanges when organized around a profile of interest, phenomenon, or problem area. The advantages and disadvantages are contrasted with those of the conventional journal system. A complementary set of virtues and weaknesses for the two modes raises the suggestion that scientific societies and journals should investigate formalized preprint exchanges as an extension of present scientific communication mechanisms. The observations are based upon the six-year experience of the information exchange groups program in biomedical areas of the national institutes of health.
N1  - Accession Number: ISTA0502081; Bever, Arley T 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: February 1969, Vol. 9 Issue 1, p3; Note: Update Code: 0500; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Connor, Robert J.
AU  - Mosimann, James E.
T1  - CONCEPTS OF INDEPENDENCE FOR PROPORTIONS WITH A GENERALIZATION OF THE DIRICHLET DISTRIBUTION.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1969/03//
VL  - 64
IS  - 325
M3  - Article
SP  - 194
SN  - 01621459
AB  - Concepts of independence for nonnegative continuous random variables, X[sub 1],..., X[sub k], subject to the constraint SIGMA X[sub i] = 1 are developed. These concepts provide a means of modeling random vectors of proportions which is useful in analyzing certain kinds of data; and which may be of interest in quantifying prior opinions about multinomial parameters. A generalization of the Dirichlet distribution is given, and its relation to the Dirichlet is simply indicated by means of the concepts.  The concepts are used to obtain conclusions of biological interest for data on bone composition in rats and scute growth in turtles. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RANDOM variables
KW  - DISTRIBUTION (Probability theory)
KW  - STATISTICS
KW  - PROBABILITY theory
KW  - INDEPENDENCE (Mathematics)
KW  - DIRICHLET principle
KW  - GENERALIZATION
KW  - BIOLOGICAL assay
KW  - VARIABLES (Mathematics)
N1  - Accession Number: 4603649; Connor, Robert J. 1; Mosimann, James E. 1; Affiliations: 1: National Institutes of Health, Public Health Service; Issue Info: Mar1969, Vol. 64 Issue 325, p194; Thesaurus Term: RANDOM variables; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: INDEPENDENCE (Mathematics); Subject Term: DIRICHLET principle; Subject Term: GENERALIZATION; Subject Term: BIOLOGICAL assay; Subject Term: VARIABLES (Mathematics); Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
T1  - PSYCHOPHYSIOLOGY OF CONDITIONED EMOTIONAL DISTURBANCES IN HUMANS.
AU  - Frazier, Thomas W.
AU  - Weil-Malherbe, Hans
AU  - Lipscomb, Harry S.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1969/03//
VL  - 5
IS  - 5
SP  - 478
EP  - 503
SN  - 00485772
N1  - Accession Number: 11237629; Author: Frazier, Thomas W.: 1 Author: Weil-Malherbe, Hans: 2 Author: Lipscomb, Harry S.: 3 ; Author Affiliation: 1 Walter Reed Army  Institute of Research.: 2 National  Institute of Mental Health,  St. Elizabeth's Hospital.: 3 Baylor University College of Medicine.; No. of Pages: 26; Language: English; Publication Type: Article; Update Code: 20031223
N2  - A discriminative avoidance conditioning technique was used to study urinary excretion of selected adrenal hormones in response to a stimulus which had acquired conditioned noxious properties through association with availability of punishment. A four day test procedure was employed: (1) to habituate subjects to the test environment; (2) obtain control data; (3) condition subjects; and (4) test reactions to the conditioned noxious stimulus. Urine samples were taken at two-hour intervals preceding and following each of the four trials, and were analyzed for epinephrine, norepinephrine, total 17-hydroxycorticosteroids, and other urinary constituents. These results were correlated with results obtained from monitoring of heart rate, skin resistance, blood pressure, and three measures of panel monitoring performance. Data analyses revealed significant changes from control levels during the test period for each of the principal measures described above and some specification of life systems interrelationships through correlation and factor analyses. Factors were identified which related to behavioral efficiency, psychological effort, fluid transport regulation, cardiovascular-adrenal, and specific epinephrine and norepinephrine factors. ABSTRACT FROM AUTHOR
KW  - *ADRENAL cortex
KW  - VIGILANCE (Psychology)
KW  - AUTONOMIC conditioning
KW  - PUNISHMENT (Psychology)
KW  - Adrenal
KW  - Autonomic
KW  - Factor analysis
KW  - Human avoidance conditioning
KW  - Punishment. (T. Frazier)
KW  - Vigilance
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - CONF
AU  - Cox, Jackee
T1  - Health Aspects of the International Movement of Animals.
JO  - BioScience
JF  - BioScience
Y1  - 1969/04//
VL  - 19
IS  - 4
M3  - Proceeding
SP  - 370
EP  - 371
SN  - 00063568
AB  - The article discusses the highlights of the Inter-American Symposium on Health Aspects of the International Movement of Animals that was held on August 28-30, 1968 in San Antonio, Texas. The symposium, co-sponsored by the Pan American Health Organization and the Conference of Public Health Veterinarians, discussed human health problems arising from animal diseases, including the dangers posed by diseases directly transmissible to man from animals. Among the speakers was Abraham Horwitz, president of the Pan American Health Organization.
KW  - Conferences & conventions
KW  - Animal health -- Congresses
KW  - San Antonio (Tex.)
KW  - Texas
KW  - Pan American Health Organization -- Congresses
N1  - Accession Number: 32757014; Cox, Jackee 1; Affiliations: 1 : Division of Research, Facilities and Resources, National Institutes of Health, Bethesda, Md.;  Source Info: Apr1969, Vol. 19 Issue 4, p370; Subject Term: Conferences & conventions; Subject Term: Animal health -- Congresses; Subject: San Antonio (Tex.); Subject: Texas; Number of Pages: 2p; Document Type: Proceeding
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Miller, J. R.;
AU  - Helprin, J. J.;
AU  - Finlayson, J. S.;
T1  - Silicone lubricant flushed from disposable syringes: determination by atomic absorption spectrophotometry
CT  - Silicone lubricant flushed from disposable syringes: determination by atomic absorption spectrophotometry
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1969/04/01/
VL  - 58
IS  - Apr
SP  - 455
EP  - 456
SN  - 00223549
AD  - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0830; Language: English; References: 4; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Technology; Abstract Author: D. R. Tousignaut
N2  - Amounts of silicone removable from disposable plastic syringes were determined (as silicone) by the use of atomic absorption spectrophotometry. This method revealed that the silicone fluid employed as a lubricant was present in distilled water expressed from 20 to 60% of the syringes. As contrasted with the total silicone extractable by dissolving with methyl isobutyl ketone, water-removable silicone appeared to be removed by a mechanical flushing action. The ability of water to remove appreciable quantities of silicone correlated with the presence of local accumulations of silicone lubricant on the plunger tip. However, owing to the translucent nature of plastic syringes, these accumulations are only detectable by visual inspection after removal of the plunger from the barrel. Inasmuch as disposable syringes are packaged in a sterile and assembled condition, removal of the plunger for inspection would be impractical for aseptic use.
KW  - Silicone--lubricants-;
KW  - Lubricants--silicone--syringes, disposable, atomic absorption spectrometry;
KW  - Syringes--disposables--lubricants, silicone, atomic absorption spectrometry;
KW  - Disposables--syringes--lubricants, silicone, atomic absorption spectrometry;
KW  - Spectrometry, atomic absorption--silicone--lubricants, flushed from disposable syringes;
KW  - Plastics--syringes--disposable, silicone lubricant flushed from, atomic absorption spectrometry;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ager, J. H.;
AU  - May, E. L.;
T1  - New compounds: oxazolidines and derived amino alcohols
CT  - New compounds: oxazolidines and derived amino alcohols
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1969/04/01/
VL  - 58
IS  - Apr
SP  - 499
EP  - 500
SN  - 00223549
AD  - Laboratory of Chemistry, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-1004; Language: English; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
KW  - Oxazolidines--and derived amino alcohols--new compounds;
KW  - Alcohols--derived amino--and oxazolidines, new compounds;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-40692-011
AN  - 2013-40692-011
AU  - Wender, Paul H.
T1  - The role of genetics in the etiology of the schizophrenias.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1969/04//
VL  - 39
IS  - 3
SP  - 447
EP  - 458
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Wender, Paul H., Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US
N1  - Accession Number: 2013-40692-011. PMID: 4891115 Partial author list: First Author & Affiliation: Wender, Paul H.; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1968, Chicago, IL, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Etiology; Genetics; Mental Disorders; Psychopathology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: Apr, 1969. 
AB  - Both experiential and genetic factors have been implicated in the etiology of schizophrenia but their relative roles have been impossible to assess. Recent studies using the technique of adoption to separate the effects of 'nature' and 'nurture' have shown that genetic factors play an important role in the etiology of schizophrenia and may also play a role in the development of other psychiatric illnesses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - genetics
KW  - etiology
KW  - schizophrenia
KW  - psychiatric illnesses
KW  - psychopathology
KW  - 1969
KW  - Etiology
KW  - Genetics
KW  - Mental Disorders
KW  - Psychopathology
KW  - Schizophrenia
KW  - 1969
DO  - 10.1111/j.1939-0025.1969.tb00640.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40692-013
AN  - 2013-40692-013
AU  - Pedersen, Frank A.
AU  - Robson, Kenneth S.
T1  - Father participation in infancy.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1969/04//
VL  - 39
IS  - 3
SP  - 466
EP  - 472
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Pedersen, Frank A., National Institute of Child Health and Human Development, Building 1 2A, Room 3001, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-40692-013. PMID: 5783741 Partial author list: First Author & Affiliation: Pedersen, Frank A.; National Institutes of Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1968, Chicago, IL, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Childhood Development; Father Child Relations; Fathers; Parenting. Minor Descriptor: Social Behavior. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Interview; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1969. 
AB  - Although the importance of paternal influence on child development is now generally accepted, we actually know very little about normal father-infant relationships. This study, undertaken to define some of them, found a wide variation among a homogeneous middle-class group. No factor was consistent for infants of both sexes. But results showed enough significant correlations to support the need for more developmental studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - father participation
KW  - child development
KW  - father infant relationships
KW  - social behavior
KW  - parenting
KW  - 1969
KW  - Childhood Development
KW  - Father Child Relations
KW  - Fathers
KW  - Parenting
KW  - Social Behavior
KW  - 1969
DO  - 10.1111/j.1939-0025.1969.tb00642.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bonadonna, G.;
AU  - Monfardini, S.;
T1  - Cardiac toxicity of daunorubicin
CT  - Cardiac toxicity of daunorubicin
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1969/04/19/
VL  - 1
IS  - Apr 19
SP  - 837
SN  - 00237507
AD  - Clinical Chemotherapy Unit, National Cancer Institute, Milan, Italy
N1  - Accession Number: 7-2673; Language: English; References: 7; Journal Coden: LANCAO; Section Heading: Adverse Drug Reactions; Abstract Author: Lamar Orr
N2  - Acute cardiac failure and death occurred in 5 of 16 patients, average age 54 years, receiving total doses of daunorubicin (daunomycin) as low as 300-600 mg. The myocardium of adults and especially that of elderly patients is doubtless more vulnerable to the toxic effects of the drug than is that of children
KW  - Daunomycin--toxicity-;
KW  - Toxicity--daunomycin--cardiac;
KW  - Drugs, adverse reactions--daunomycin--cardiac toxicity;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bunney, W. E.;
AU  - Janowsky, D. S.;
AU  - Goodwin, F. K.;
AU  - Davis, J. M.;
AU  - Brodie, H. K. H.;
T1  - Effect of L-dopa on depression
CT  - Effect of L-dopa on depression
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1969/04/26/
VL  - 1
IS  - Apr 26
SP  - 885
EP  - 886
SN  - 00237507
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0180; Language: English; References: 9; Publication Type: Letters to the Editor; Journal Coden: LANCAO; Section Heading: Drug Evaluations; Abstract Author: Lamar Orr
N2  - A clear reversal of the symptoms of depression was demonstrated in a 56-year-old woman with large doses of L-dopa administered orally. The observed effect indicates that some depressions may be associated with a functional deficit of brain noradrenaline and/or dopamine.
KW  - Dopa--L--;
KW  - Antidepressants--L-dopa--symptoms reversed;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Eddy, N. B.;
AU  - Friebel, H.;
AU  - Hahn, K.-J.;
AU  - Halbach, H.;
T1  - Codeine and its alternates for pain and cough relief. Part 4. Potential alternates for cough relief
CT  - Codeine and its alternates for pain and cough relief. Part 4. Potential alternates for cough relief
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1969/05/01/
VL  - 40
IS  - May
SP  - 639
EP  - 719
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0699; Language: English; Chemical Name: Codeine--6059-47-8; References: 456; Journal Coden: BWHOA6; Section Heading: Pharmacology
N2  - In this report, the fourth of a series on codeine and its alternates for pain and cough relief, an attempt is made to evaluate, on the basis of experimental and clinical data, and wherever possible in comparison with codeine, the effectiveness of a number of antitussive substances currently in clinical use. In the discussion of the undesired side effects particular attention is paid to the risk of dependence and abuse.
KW  - Codeine--alternative therapy-;
KW  - Toxicity--codeine--risk of dependence and abuse, WHO report;
KW  - Dependence--codeine--risks, WHO report;
KW  - Drug abuse--codeine--risks, WHO report;
KW  - Expectorants and cough preparations--alternatives for codeine--in cough relief, WHO report;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Eddy, N. B.;
AU  - Friebel, H.;
AU  - Hahn, K.-J.;
AU  - Halbach, H.;
T1  - Codeine and its alternatives for pain and cough relief. Part 5. Discussion and summary
CT  - Codeine and its alternatives for pain and cough relief. Part 5. Discussion and summary
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1969/05/01/
VL  - 40
IS  - May
SP  - 721
EP  - 730
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0990; Language: English; Chemical Name: Codeine--6059-47-8; References: 18; Journal Coden: BWHOA6; Section Heading: Pharmacology; Abstract Author: Walter F. Stanaszek
N2  - A discussion on the value of an alternate for codeine concludes a series of articles on the effectiveness and lack of undesirable side effects of several different drugs. It is felt that other substances are available which could be used as alternates for codeine, except where analgesia, cough relief, and sedation are required simultaneously; however, no particular gain and probably no particular loss would result.
KW  - Codeine--alternative therapy-;
KW  - Toxicity--codeine--risk of dependence and abuse, WHO report;
KW  - Dependence--codeine--risks, WHO report;
KW  - Drug abuse--codeine--risks, WHO report;
KW  - Expectorants and cough preparations--alternatives for codeine--in pain and cough relief, WHO report;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levey, G. S.;
AU  - Roth, J.;
AU  - Pastan, I.;
T1  - Effect of propranolol and phentolamine on canine and bovine responses to TSH
CT  - Effect of propranolol and phentolamine on canine and bovine responses to TSH
JO  - Endocrinology
JF  - Endocrinology
Y1  - 1969/05/01/
VL  - 84
IS  - May
SP  - 1009
EP  - 1015
AD  - Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-1207; Language: English; Chemical Name: Propranolol--525-66-6 Phentolamine--50-60-2; Journal Coden: ENDOAO; Section Heading: Pharmacology
KW  - Propranolol--and phentolamine-;
KW  - Phentolamine--and propranolol-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Goldsmith, Harold F.
AU  - Stockwell, Edward G.
T1  - Interrelationship of Occupational Selectivity Patterns Among City, Suburban and Fringe Areas of Major Metropolitan Centers.
JO  - Land Economics
JF  - Land Economics
Y1  - 1969/05//
VL  - 45
IS  - 2
M3  - Article
SP  - 194
PB  - University of Wisconsin Press
SN  - 00237639
AB  - The article focuses on the interrelationship of occupational selectivity patterns among city, suburban and fringe areas of major metropolitan centers. The analysis reported in the paper is based on the occupational distributions of employed white male non-farm workers within the 76 metropolitan areas that had populations of 300,000 or more. In order to ascertain the occupational selectivity patterns of city, sub-urban and fringe resident populations, Standard Metropolitan Statistical Areas (SMSAs) were divided into zones or sub-areas as follows, the central city of an SMSA is identified as the city, the part of the urbanized area outside the central city is identified as the suburb and the area outside the urbanized area but within the SMSA is referred to as the fringe. Occupational selectivity refers to the differential residential distributions of persons in the major occupation classes. it was found that metropolitan areas with central cities in which the higher status white collar occupations were under-represented and the lower status white collar occupations usually were over-represented tended to have suburban areas in which the higher status white collar occupations were over represented and lower-status blue collar occupations were under-represented.
KW  - Labor market
KW  - Occupational prestige
KW  - Occupations -- United States
KW  - Standard metropolitan statistical areas
KW  - Blue collar workers
KW  - White collar workers
KW  - White collar workers -- United States
KW  - Employee selection
KW  - Metropolitan areas -- United States
KW  - Metropolitan areas
KW  - United States
N1  - Accession Number: 5364524; Goldsmith, Harold F. 1; Stockwell, Edward G. 2; Affiliations: 1: Chief, Population Research Section, Mental Health Study Center, National Institute of Mental Health.; 2: Professor of Rural Sociology, University of Connectient.; Issue Info: May69, Vol. 45 Issue 2, p194; Subject Term: Labor market; Subject Term: Occupational prestige; Subject Term: Occupations -- United States; Subject Term: Standard metropolitan statistical areas; Subject Term: Blue collar workers; Subject Term: White collar workers; Subject Term: White collar workers -- United States; Subject Term: Employee selection; Subject Term: Metropolitan areas -- United States; Subject Term: Metropolitan areas; Subject: United States; Number of Pages: 12p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Evan, William M.
AU  - Simmons, Roberta G.
T1  - Organizational Effects of Inequitable Rewards: Two Experiments in Status Inconsistency.
JO  - Administrative Science Quarterly
JF  - Administrative Science Quarterly
Y1  - 1969/06//
VL  - 14
IS  - 2
M3  - Article
SP  - 224
EP  - 237
PB  - Administrative Science Quarterly
SN  - 00018392
AB  - Two organizational experiments were conducted to investigate the effects of overpayment and underpayment. Subjects were confronted with one of two organizational sources of inequitable payment. In one experiment their salary was inconsistent with their officially recognized level of competence; in another, their salary was inconsistent with their level of authority. Students were hired as proofreaders and worked in the actual offices of a publishing company. Status inconsistency was found to exert a significant effect on performance and to a lesser extent on conformity to organizational rules. Underpaid subjects behaved in accordance with equity theory by producing work of a lower level of quality; however, overpaid subjects did not behave consistently with the theory. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Administrative Science Quarterly is the property of Administrative Science Quarterly and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PAYMENT
KW  - COMPENSATION management
KW  - OVERPAYMENT
KW  - PAY equity
KW  - WAGE payment systems
KW  - WAGES
KW  - EQUAL pay for equal work
KW  - ORDINARY income
KW  - EARNED income
KW  - LABOR costs
KW  - INCOME
KW  - PERFORMANCE
N1  - Accession Number: 4026768; Evan, William M. 1; Simmons, Roberta G. 2; Affiliations: 1: professor of sociology and industry, University of Pennsylvania; 2: special faculty research fellow, national institutes of health, laboratory of research in social relations, University of Minnesota; Issue Info: Jun69, Vol. 14 Issue 2, p224; Thesaurus Term: PAYMENT; Thesaurus Term: COMPENSATION management; Thesaurus Term: OVERPAYMENT; Thesaurus Term: PAY equity; Thesaurus Term: WAGE payment systems; Thesaurus Term: WAGES; Thesaurus Term: EQUAL pay for equal work; Thesaurus Term: ORDINARY income; Thesaurus Term: EARNED income; Thesaurus Term: LABOR costs; Thesaurus Term: INCOME; Subject Term: PERFORMANCE; NAICS/Industry Codes: 541612 Human Resources Consulting Services; Number of Pages: 14p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P. S.;
T1  - 1-Methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide
CT  - 1-Methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/06/01/
VL  - 29
IS  - Jun
SP  - 1226
EP  - 1232
SN  - 00085472
AD  - Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-0673; Language: English; Chemical Name: Urea--57-13-6; References: 38; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - 1-Methyl-1-nitrosourea (MNU), the active moiety of the streptozotocin molecule, produces a dose-related depression of nicotinamide adenine dinucleotide (NAD) concentrations in mouse liver and L1210 ascites, similar to that produced by streptozotocin. Pretreatment with nicotinamide prevented the decrease in NAD; however, it did not influence either the toxicity or antineoplastic activity of MNU.
KW  - Urea--1-methyl-1-nitroso--;
KW  - Nicotinamide--prevention of 1-methyl-1-nitrosourea produced decrease in nicotinamide adenine dinucleotide-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goldman, P.;
T1  - Carbon-fluorine bond in compounds of biological interest
CT  - Carbon-fluorine bond in compounds of biological interest
JO  - Science
JF  - Science
Y1  - 1969/06/06/
VL  - 164
IS  - Jun 6
SP  - 1123
EP  - 1130
AD  - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0536; Chemical Name: Carbon--7440-44-0 Fluorine--7782-41-4; References: 83; Journal Coden: SCIEAS; Section Heading: Pharmaceutical Chemistry; Abstract Author: Robert A. Hall
N2  - The importance of fluorine incorporated into pharmacological agents is related to either its size or its electronegativity. This review article includes discussions of the carbon-fluorine bond in selective inhibition of biological processes and in the design of more active therapeutic agents.
KW  - Carbon--fluorine bond-;
KW  - Fluorine--carbon bond-;
KW  - Bonding--carbon-fluorine--in compounds of biological interest;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Glueck, C. J.;
AU  - Brown, W. V.;
AU  - Levy, R. I.;
AU  - Greten, H.;
AU  - Fredrickson, D. S.;
T1  - Amelioration of hypertriglyceridemia by progestational drugs in familial type-V hyperlipoproteinemia
CT  - Amelioration of hypertriglyceridemia by progestational drugs in familial type-V hyperlipoproteinemia
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1969/06/28/
VL  - 1
IS  - Jun 28
SP  - 1290
EP  - 1291
SN  - 00237507
AD  - Molecular Disease Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-1616; Language: English; Chemical Name: Norethindrone--68-22-4; References: 18; Publication Type: Preliminary Communications; Journal Coden: LANCAO; Section Heading: Drug Evaluations
N2  - Administration of norethindrone acetate resulted in marked clearing of hyperglyceridemia in 4 patients with familial type-V hyperlipoproteinemia. This progestational agent was responsible for a 2-10 fold decrease in plasma triglyceride, and a concurrent increase in post-heparin lipolytic activity. In these cases progestational agents represented new and effective therapy for type-V hyperlipoproteinemia.
KW  - Norethindrone--acetate-;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Powers, K. G.;
T1  - Activity of chlorinated lincomycin analogs against Plasmodium cynomolgi in rhesus monkeys
CT  - Activity of chlorinated lincomycin analogs against Plasmodium cynomolgi in rhesus monkeys
JO  - Am. J. Trop. Med. Hyg.
JF  - Am. J. Trop. Med. Hyg.
Y1  - 1969/07/01/
VL  - 18
IS  - Jul
SP  - 485
EP  - 490
AD  - Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-3637; Language: English; Chemical Name: Lincomycin--154-21-2; Therapeutic Class: (8:12); AHFS Class: Antibiotics lincomycin (8:20); AHFS Class: Plasmodicides lincomycin; References: 8; Journal Coden: AJTHAB; Section Heading: Preliminary Drug Testing; Abstract Author: Joan M. Anderson
N2  - Analogs are prepared by substituting chlorine for the hydroxyl group at the 7 position in the amino-sugar moiety of lincomycin or its semi-synthetic derivatives. The resulting compounds are more rapidly absorbed, give higher concentrations in the blood, penetrate tissues more rapidly, and have greater antibacterial activity than their nonchlorinated counterparts. Acute infections were treated by oral or subcutaneous administration for 5 consecutive days with doses ranging from 6.25 mg. to 100 mg./kg. body weight. Cures were obtained when U-21,251F (7-chlorolincomycin) and U-24,729A (7-chloro-N-demethyl-4\DP/-pentyllincomycin) were given orally at 50 mg./kg., and when U-26,285A (7-chloro-N-demethyllincomycin) was given at 100 mg./kg. U-24,729A and U-26,285A were also curative when given subcutaneously at 25 and 50 mg./kg. respectively. With all dosage regimens the blood was cleared of parasites 3 to 6 days after cessation of treatment. The rate of clearance of parasites did not appear to be related to dose. No side effects due to the antibiotics were observed.
KW  - Lincomycin--derivatives-;
KW  - Antibiotics--lincomycin--derivatives, chlorinated, activity against P. cynomolgi, in rhesus monkeys;
KW  - Plasmodicides--lincomycin--derivatives, chlorinated, activity against P. cynomolgi, in rhesus monkeys;
KW  - Absorption--lincomycin--derivatives, chlorinated;
KW  - Blood levels--lincomycin--derivatives, chlorinated;
KW  - Metabolism--lincomycin--derivatives, chlorinated;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Wolff, J.;
T1  - Iodide goiter and the pharmacologic effects of excess iodide
CT  - Iodide goiter and the pharmacologic effects of excess iodide
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1969/07/01/
VL  - 47
IS  - Jul
SP  - 101
EP  - 124
SN  - 00029343
AD  - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-1198; Language: English; References: 280; Journal Coden: AJMEAZ; Section Heading: Pharmacology; Abstract Author: Philip D. Hansten
N2  - This review concerns itself with the effects of excess iodide, i.e., amounts greater than those needed for the production of normal amounts of the thyroid hormones. Drugs which serve, in many cases, as sources of excessive iodide intake are described.
KW  - Iodides--excess--iodide goiter and pharmacological effects;
KW  - Drugs--excessive iodide intake sources--description;
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ER  - 

TY  - JOUR
AU  - Paul, W. E.
AU  - Thorbecke, G. Jeanette
AU  - Siskind, G. W.
AU  - Benacerraf, B.
T1  - The Effect of Dose in Tolerance Induction on the Subsequent Response to a Cross-Reactive Antigen.
JO  - Immunology
JF  - Immunology
Y1  - 1969/07//
VL  - 17
IS  - 1
M3  - Article
SP  - 85
EP  - 92
SN  - 00192805
AB  - The amount of antibody produced by BSA-tolerant rabbits as a result of immunization with DNP-BSA is dependent upon the amount of BSA used to induce tolerance. Tolerance was induced by initial injection of 100 μg of antigen followed by progressively higher doses. Rabbits rendered tolerant with a maximum BSA dose of 1 mg had a mean serum anti-BSA antibody concentration of 0·39 mg/ml after immunization with DNP-BSA, whereas rabbits rendered tolerant with a maximum BSA dose of 100 mg had a mean serum anti-BSA concentration of 0·02 mg after the same course of immunization. This compares with a mean of 1·08 mg of anti-BSA antibody in normal rabbits immunized with DNP-BSA. There was a similar reduction in the concentration of anti-DNP anti-bodies and of conjugate-specific antibodies in the tolerant groups. The results are discussed in terms of a thermodynamically-controlled induction of tolerance in individual precursor cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - IMMUNIZATION
KW  - RABBITS as laboratory animals
KW  - ADMINISTRATION of drugs
KW  - CELLS
KW  - IMMUNOLOGY
N1  - Accession Number: 13354172; Paul, W. E. 1; Thorbecke, G. Jeanette 1; Siskind, G. W. 1; Benacerraf, B. 1,2,3; Source Information: Jul69, Vol. 17 Issue 1, p85; Subject: IMMUNOGLOBULINS; Subject: IMMUNIZATION; Subject: RABBITS as laboratory animals; Subject: ADMINISTRATION of drugs; Subject: CELLS; Subject: IMMUNOLOGY; Number of Pages: 8p; Document Type: Article
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DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - White, W. C.;
AU  - Allen, S. I.;
AU  - Otten, M.;
AU  - Swarthe, E.;
T1  - Experimental computer network for medical data processing
CT  - Experimental computer network for medical data processing
JO  - Methods Inf. Med.
JF  - Methods Inf. Med.
Y1  - 1969/07/01/
VL  - 8
IS  - Jul
SP  - 113
EP  - 120
AD  - Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3563; Language: English; Language of Summary: ger; References: 18; Journal Coden: MIMCAI; Section Heading: Information Processing and Literature
N2  - Methods for supplying medical personnel, especially in isolated areas, with the same sophisticated medical information and computational facilities that are available in major medical centers, were investigated. Inexpensive, readily available input/output terminals, including the push button telephone, were tested with several biomedical application programs. An experimental network, consisting of several independent commercial time-sharing computers linked to user terminals through a small communication control computer, was constructed to demonstrate an efficient and flexible approach to remote computer access. The communication control computer, acting as a message handling and translating interface, allowed the use of a uniform terminal control language and common data handling conventions. By linking to the most powerful commercial time-sharing systems available, a reliable medical data processing network was established without a major investment in computer hardware or system software.
KW  - Automation, data processing--computers--experimental system provides economical medical information and computational facilities;
KW  - Information--medical--experimental data processing system provides economical service;
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DB  - ipa
ER  - 

TY  - GEN
AU  - Allen, S I
AU  - Otten, M
AU  - Swarthe, E
T1  - An experimental computer network for medical data processing
JO  - Methods of Information in Medicine
JF  - Methods of Information in Medicine
Y1  - 1969/07//
VL  - 8
IS  - 3
M3  - Article
SP  - 113
EP  - 120
SN  - 00261270
AB  - Methods for suppling medical personnel, especially in isolated areas, with the same sophisticated medical information and computational facilities that are available in major medical centers were investigated. Inexpensive, readily available input/output terminals, including the pushbutton telephone, were tested with several biomedical application programs. An experimental network, consisting of several independent commercial time-sharing computers linked to user terminals through a small communication control computer, was constructed to demonstrate an efficient and flexible approach to remote computer access. The communication control computer, acting as a message handling and translating interface, allowed the use of a uniform terminal control language and common data handling conventions. By linking to the most powerful commercial time-sharing systems available, a reliable medical data processing network was established without a major investment in computer hardware or system software. This experimental work is a major part of the medical information telecommunication project in the devision of computer research and technology (dcrt) at the national institutes of health
N1  - Accession Number: ISTA0500819; Allen, S I 1; Otten, M; Swarthe, E; Affiliations: 1 : Division Of Computer Research And Technology, National Institutes Of Health.;  Source Info: July 1969, Vol. 8 Issue 3, p113; Note: Update Code: 0500; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Meyer, H. M.;
AU  - Parkman, P. D.;
AU  - Hopps, H. E.;
T1  - Control of rubella
CT  - Control of rubella
JO  - Pediatrics (USA)
JF  - Pediatrics (USA)
Y1  - 1969/07/01/
VL  - 44
IS  - Jul
SP  - 5
EP  - 0
SN  - 00314005
AD  - Laboratory of Viral Immunology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-1124; Language: English; References: 68; Journal Coden: PEDIAU; Section Heading: Drug Evaluations; Pharmacology
N2  - Intranasal challenge of rubella vaccines with natural rubella virus demonstrated that vaccine induced antibodies were protective against the clinical and virologic manifestations of rubella. Observation of vaccinated children over a 3-year period has demonstrated little evidence of a decline in the antibodies. Fully attenuated rubella virus vaccines have not produced significant clinical reactions in children. However, mild rubella-like symptoms have been observed in adult women receiving vaccine; transient rashes, lymphadenopathy, arthralgia, and arthritis have been observed. Since the risk of spread of attenuated virus to the fetus in vaccinated women cannot be readily determined, the use of the vaccine during pregnancy would be potentially hazardous.
KW  - Rubella vaccines--rubella control-;
KW  - Toxicity--rubella vaccines--risk during pregnancy;
KW  - Immunization--rubella--control discussed;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gallo, R. C.;
AU  - Whang-Peng, J.;
AU  - Perry, S.;
T1  - Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin
CT  - Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin
JO  - Science
JF  - Science
Y1  - 1969/07/25/
VL  - 165
IS  - Jul 25
SP  - 400
EP  - 402
AD  - Human Tumor Cell Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-1201; Language: English; References: 24; Journal Coden: SCIEAS; Section Heading: Pharmacology; Abstract Author: Robert A. Hall
N2  - Isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin-stimulated lymphocyte. The stage of cell cycle and the concentrations used are critical for these effects. The authors suggest isopentenyladenosine might be useful in the treatment of some neoplasias not only for its direct antitumor effects but to help trigger some cells to divide.
KW  - Isopentenyladenosine--effects-;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Kasel, J. A.;
AU  - Rossen, R. D.;
AU  - Fulk, R. V.;
AU  - Fedson, D. S.;
AU  - Couch, R. B.;
AU  - \ET/;
T1  - Human influenza: aspects of the immune response to vaccination
CT  - Human influenza: aspects of the immune response to vaccination
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1969/08/01/
VL  - 71
IS  - Aug
SP  - 369
EP  - 398
SN  - 00034819
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-3407; Language: English; References: 99; Publication Type: NIH Clinical Staff Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2  - The studies presented in this conference illustrate some of the newer aspects of the immune response to infection with influenza virus and vaccination with inactivated vaccines. The predominant immunoglobulin in respiratory secretions is an 11S IgA dimer that is distinguishable from serum IgA. Intranasal immunization with inactivated vaccines resulted in higher titers and greater duration of antibody in respiratory secretions than did subcutaneous vaccination. In addition, if given in adequate dosages, vaccination by this method resulted in significant levels of humoral antibody in most vaccinees. The degree of both serum and nasal antibody responses was shown to be related to the age and prior immunologic experience of the vaccinated individual. Initial studies from challenge experiments suggested that intranasal vaccination was as effective as subcutaneous vaccination in reducing infection.
KW  - Influenza vaccines--inactivated-;
KW  - Immunization--influenza--aspects of immune response to vaccination;
KW  - Drug administration--influenza vaccines--inactivated, intranasal and subcutaneous immunization, aspects of immune response;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Katz, R. I.;
AU  - Kopin, I. J.;
T1  - Release of norepinephrine-3H and serotonin-3H evoked from brain slices by electrical field stimulation--calcium dependency and the effects of lithium, ouabain and tetrodotoxin
CT  - Release of norepinephrine-3H and serotonin-3H evoked from brain slices by electrical field stimulation--calcium dependency and the effects of lithium, ouabain and tetrodotoxin
JO  - Biochem. Pharmacol.
JF  - Biochem. Pharmacol.
Y1  - 1969/08/01/
VL  - 18
IS  - Aug
SP  - 1935
EP  - 1939
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0241; Language: English; Chemical Name: Ouabain--11018-89-6 Lithium--7439-93-2 Tetrodotoxin--4368-28-9 Calcium--7440-70-2; References: 22; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: A. Leon Moore
N2  - Slices of mammalian brain accumulate tritiated norepinephrine or serotonin when incubated in a medium with these compounds; mild electrical stimulation of short duration induces a striking increase in the release of exogenous labeled amine. Electrically stimulated release of norepinephrine-3H, but not of serotonin-3H, is calcium dependent. Stimulation induced release of both monoamines is significantly diminished by the addition of ouabain, lithium or tetrodotoxin to the perfusing medium. Because the effect of lithium on norepinephrine-3H was reversed by augmented calcium concentration, it appears that lithium may act directly or indirectly to interfere with calcium participation in stimulus-release coupling. In contrast to the inhibitory effect of low calcium on the release of norepinephrine-3H from brain slices, the absence of calcium in the superfusate does not appear to interfere with the release of serotonin-3H. Thus it appears that the mechanism of release of serotonin is different from that of norepinephrine. These findings suggest that electrical field stimulation induced release of labeled monoamines from brain slices may serve as a useful model for studying central release mechanisms as well as for detailed observations of the mode of action of drugs affecting the central nervous system.
KW  - Ouabain--decrease stimulation induced release of monoamines-;
KW  - Lithium--decreases stimulation induced release of monoamines-;
KW  - Tetrodotoxin--decreases stimulation induced release of monoamines-;
KW  - Calcium--role in release mechanisms of monoamines-;
KW  - Central nervous system drugs--mode of action--central release mechanisms studied;
KW  - Methodology--electrical field stimulation--central release mechanisms studied, in brain slices;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Suskind, R. G.;
AU  - Pry, T. W.;
AU  - Rabotti, G. F.;
T1  - Effect of Rous sarcoma virus infection on recovery of nucleolar RNA, ribonucleoprotein, and DNA synthesis from inhibition by actinomycin D (dactinomycin)
CT  - Effect of Rous sarcoma virus infection on recovery of nucleolar RNA, ribonucleoprotein, and DNA synthesis from inhibition by actinomycin D (dactinomycin)
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/08/01/
VL  - 29
IS  - Aug
SP  - 1598
EP  - 1605
SN  - 00085472
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0765; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0; Journal Coden: CNREA8; Section Heading: Microbiology
KW  - Dactinomycin--effect of Rous sarcoma virus infection on recovery of nucleolar RNA, ribonucleoprotein, and DNA synthesis from inhibition-;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - Frank, M. M.
AU  - Humphrey, J. H.
T1  - Spontaneous Re-Aggregation of IgM Subunits and Restoration of Antibody Activity After Reduction and Alkylation of Rabbit Anti-Forssman Antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1969/08//
VL  - 17
IS  - 2
M3  - Article
SP  - 237
EP  - 247
SN  - 00192805
AB  - Highly purified rabbit IgM anti-Forssman antibody, after reduction in dilute solution with 2-mercaptoethanol and alkylation with iodoacetamide, showed no diminution and often some increase in haemagglutination of sheep erythrocytes. The capacity to cause complement dependent lysis was, however, destroyed. It is shown that despite reduction and alkylation reaggregation of the subunits occurs to a variable extent producing non-covalently bound aggregates with S values ranging from 7 to more than 20. The aggregates can bind specifically to and agglutinate erythrocytes with greater effectiveness as their size increases. This spontaneous re-aggregation is not prevented by the presence of gelatin, but fails to occur when the IgM antibody is reduced in the presence of a variety of other proteins. The effect of extraneous proteins is evident only when they are present at the time of reduction or are added within 10–15 minutes. It is suggested that following rupture of the interchain disulphide bonds, the IgM molecule can undergo a complex, time-dependent rearrangement into new stable forms which retain combining site activity but do not involve covalent bonds. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN G
KW  - IMMUNOGLOBULINS
KW  - CHEMICAL reduction
KW  - ALKYLATION
KW  - IMMUNOLOGY
KW  - PROTEOMICS
N1  - Accession Number: 13355393; Frank, M. M. 1,2; Humphrey, J. H. 3; Source Information: Aug69, Vol. 17 Issue 2, p237; Subject: IMMUNOGLOBULIN G; Subject: IMMUNOGLOBULINS; Subject: CHEMICAL reduction; Subject: ALKYLATION; Subject: IMMUNOLOGY; Subject: PROTEOMICS; Number of Pages: 11p; Document Type: Article
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DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Murphy, D. L.;
AU  - Goodwin, F. K.;
AU  - Bunney, W. E., Jr.;
T1  - Aldosterone and sodium response to lithium administration in man
CT  - Aldosterone and sodium response to lithium administration in man
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1969/08/30/
VL  - 2
IS  - Aug 30
SP  - 458
EP  - 460
SN  - 00237507
AD  - Clinical Center, National Institutes of Health, 10-3 S229, Bethesda, Maryland 20014
N1  - Accession Number: 7-2094; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 21; Journal Coden: LANCAO; Section Heading: Pharmacology
N2  - Administration of lithium carbonate to 16 manic-depressive and depressed patients was found to lead to an initial 1-2 days of sodium and water diuresis. In the subsequent 4-5 day period of treatment, sodium retention associated with a 50% increase in aldosterone excretion occurred, followed in the next several days by a return towards prelithium levels. These changes occurred in all patients and were apparently not related to the initial clinical state of the patient nor the presence or absence of symptomatic improvement with lithium.
KW  - Lithium carbonate--aldosterone and sodium response-;
KW  - Psychotherapeutic agents--lithium carbonate--aldosterone and sodium response;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hirshaut, Y.;
AU  - Weiss, G. H.;
AU  - Perry, S.;
T1  - Use of long-term human leukocyte cell cultures as models for the study of antileukemic agents
CT  - Use of long-term human leukocyte cell cultures as models for the study of antileukemic agents
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/09/01/
VL  - 29
IS  - Sep
SP  - 1732
EP  - 1740
SN  - 00085472
AD  - National Cancer Institute, Building 10, Room 6 B 17, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0785; Language: English; Chemical Name: Mercaptopurine--6112-76-1 Methotrexate--59-05-2 Vincristine--57-22-7 Prednisolone--50-24-8; References: 21; Journal Coden: CNREA8; Section Heading: Methodology
N2  - Long-term human leukocyte cell cultures were exposed to 4 antineoplastic agents to determine the relationship between drug concentration and cell exposure time to cell kill. The drugs tested were mercaptopurine, methotrexate, vincristine, and prednisolone. The studies provide new insight into the concentration-time relationship of the 4 test drugs. The results indicate that long-term human leukocyte culture models may be useful in the evaluation of some factors determining the effectiveness of a drug as a chemotherapeutic agent.
KW  - Mercaptopurine--evaluation-;
KW  - Methotrexate--evaluation-;
KW  - Vincristine--evaluation-;
KW  - Prednisolone--evaluation-;
KW  - Antineoplastic agents--evaluation--using long-term human leukocyte cell cultures;
KW  - Methodology--antineoplastic agents--evaluation using long-term human leukocyte cell cultures;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Adler, W. H.
AU  - Curry, Jean H.
AU  - Smith, R. T.
T1  - Immunoglobulin Peptidc Chain Synthesis in the Newborn Rabbit.
JO  - Immunology
JF  - Immunology
Y1  - 1969/09//
VL  - 17
IS  - 3
M3  - Article
SP  - 457
EP  - 468
SN  - 00192805
AB  - Lymphoid tissue from newborn rabbits was examined using fluorochrome conjugated goat antisera to rabbit γ, μ and α heavy chain and mixed light chain. Unimmunizcd newborn rabbits examined at intervals up to 20 days of age revealed a very low background of approximately one in 105 cells which stained with either the anti-μ, anti-γ or anti-L chain reagents. Newborn rabbits, immunized intrapcritoncally on the day of birth with S. paralyphi B (4, 5, 12:b), showed a 1000-fold increase in the number of stained cells; μ heavy chain containing cells were found 16 hours after immunization, and γ heavy chain containing cells were found 20 hours after immunization in the rabbit spleen tissue. The numbers of μ containing cells and γ containing cells were approximately equal at 5 days of age in tile immunized groups. No α heavy chain containing cells were found in any of tile rabbits studied. All cells which stained with the anti-μ or γ heavy chain reagent were also stained with the anti-light chain reagent. The cellular response of the immunized newborn rabbits could be inhibited by passive antibody to S. paralyphi B, either given at the time of immunization, or passively acquired from the doc. Specificity of inhibition was indicated by the failure of sheep red blood cells (SRBG) stroma to be inhibited in animals so suppressed. The range of cellular morphology of the γ chain containing and the μ chain containing cells was indistinguishable. The earliest cell to be stained with either anti-γ or anti-μ was a large blast-like cell with a thin rim of cytoplasm and a large nucleus. A full range of forms between this and typical plasma cells appeared later in each case. These findings present a paradox since γG antibody to this antigen does not appear in the serum of stroll animals following γM class in the usual sequence characteristic of adult animals. Possible explanations of this paradox arc explored. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - IMMUNIZATION
KW  - IMMUNITY
KW  - IMMUNOGLOBULINS
KW  - PLASMA cells
KW  - IMMUNOLOGY
N1  - Accession Number: 14545579; Adler, W. H. 1,2; Curry, Jean H. 1; Smith, R. T. 1; Source Information: Sep69, Vol. 17 Issue 3, p457; Subject: ANTIGENS; Subject: IMMUNIZATION; Subject: IMMUNITY; Subject: IMMUNOGLOBULINS; Subject: PLASMA cells; Subject: IMMUNOLOGY; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - McIntire, K. R.
AU  - Princler, G. L.
T1  - Prolonged Adjuvant Stimulation in Germ-Free BALB/c Mice: Development of Plasma Cell Neoplasia.
JO  - Immunology
JF  - Immunology
Y1  - 1969/09//
VL  - 17
IS  - 3
M3  - Article
SP  - 481
EP  - 487
SN  - 00192805
AB  - BALB/c mice develop a high incidence (60–80 per cent) of plasma cell tumour (PCT) following the introduction of mineral oil (MO) into the peritoneal cavity. Germ-free (GF) mice have a less developed lymphoreticular system, including a decreased number of plasma cells, than their conventional (CONV) counterparts. When GF BALB/c mice were injected i.p. with mineral oil they failed to develop the expected incidence of PCT. Only two of thirty-three GF mice (6 per cent) developed PCT, while twenty-four of thirty-one ex-GF (77 per cent) and twenty-eight of forty CONV BALB/c (70 per cent) developed PCT. The ex-GF and CONV mice had average times for PCT diagnosis of 11.3 and 11.5 months, but both GF tumours were discovered 18 months after mineral oil injection. Three groups of GF mice recieved three different sterile protein antigens along with MO and no PCT developed in these mice; in the GF group receiving MO along, both PCT arose. The GF mice in this experiment did develop a high incidence (80 per cent) of lymphoreticular neoplasms of a type more primitive than PCT. This experiment suggests the importance of microbial flora in the development and differentiation of the plasma cells which respond to a carcinogenic stimulus in a genetically susceptible host. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PLASMA cells
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - MINERAL oils
KW  - IMMUNOLOGY
N1  - Accession Number: 14545586; McIntire, K. R. 1; Princler, G. L. 1; Source Information: Sep69, Vol. 17 Issue 3, p481; Subject: PLASMA cells; Subject: ANTIGENS; Subject: IMMUNOGLOBULINS; Subject: MINERAL oils; Subject: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Cornfield, Jerome
AU  - Halperin, Max
AU  - Greenhouse, Samuel W.
T1  - AN ADAPTIVE PROCEDURE FOR SEQUENTIAL CLINICAL TRIALS.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1969/09//
VL  - 64
IS  - 327
M3  - Article
SP  - 759
SN  - 01621459
AB  - An adaptive procedure for sequential clinical trials is considered, in which an increasing proportion of patients is assigned to the better of two treatments as evidence for it accumulates. The procedure considered is a multi-stage application of an optimum two-stage procedure. In the first stage of the two-stage procedure patients are assigned to each of two treatments and in the second all are assigned to the apparently better of the two treatments. The optimum two-stage procedure is one in which the proportions assigned to each of the treatments in the first stage, 2p theta and 2p(1-theta), are such as to minimize a certain natural cost function, which depends on information available before the first stage and on the total number of patients to be treated. Multi-stage application consists of recalculating the optimum two-stage theta at each point in the sequential stream of patients and interpreting it as the proportion of the next "small" batch of patients to be assigned to treatment 1. This multi-stage procedure is not optimum but does lead to lower costs than the optimum two-stage procedure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COST control
KW  - CLINICAL trials
KW  - SEQUENTIAL analysis
KW  - GUIDELINES
KW  - PATIENTS
KW  - EVIDENCE
N1  - Accession Number: 4608152; Cornfield, Jerome 1; Halperin, Max 2; Greenhouse, Samuel W. 2; Affiliations: 1: University of Pittsburgh.; 2: National Institutes of Health.; Issue Info: Sep69, Vol. 64 Issue 327, p759; Thesaurus Term: COST control; Subject Term: CLINICAL trials; Subject Term: SEQUENTIAL analysis; Subject Term: GUIDELINES; Subject Term: PATIENTS; Subject Term: EVIDENCE; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
T1  - SKIN POTENTIAL LEVELS IN RIGHT- AND LEFT-HANDED MALES.
AU  - Wyatt, Richard
AU  - Tursky, Bernard
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1969/09//
VL  - 6
IS  - 2
SP  - 133
EP  - 137
SN  - 00485772
N1  - Accession Number: 11049682; Author: Wyatt, Richard: 1 Author: Tursky, Bernard: 2 ; Author Affiliation: 1 National Institute of Mental Health, Bethesda: 2 Massachusetts Mental Health Center; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20031208
N2  - From twelve left-handed and twelve right-handed males, skin potential levels were recorded simultaneously from both sides of the body. In both groups significantly higher skin potential levels were found on the right side. Unilateral stimuli and handedness did not unilaterally affect maximum response level. ABSTRACT FROM AUTHOR
KW  - *SKIN
KW  - *HANDEDNESS
KW  - *PSYCHOPHYSIOLOGY
KW  - MALES
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2006-06122-002
AN  - 2006-06122-002
AU  - Rosenthal, David
T1  - Whither Human Behavioral Genetics?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1969/09//
VL  - 14
IS  - 9
SP  - 457
EP  - 458
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06122-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavioral Genetics. Minor Descriptor: Psychologists. Classification: Genetics (2510). Population: Human (10). Reviewed Item: Vandenberg, Steven G. (Ed). Progress in Human Behavior Genetics: Recent Reports on Genetic Syndromes, Twin Studies, and Statistical Advances=Baltimore: Johns Hopkins Press, 1968. Pp. xi + 356. $12.50; 1968. Page Count: 2. Issue Publication Date: Sep, 1969. 
AB  - Reviews the book, Progress in Human Behavior Genetics: Recent Reports on Genetic Syndromes, Twin Studies, and Statistical Advances edited by Steven G. Vandenberg (see record [rid]1972-02467-000[/rid]). In this book, author brings together a variety of research contributions by some of the most prominent investigators in the field of human behavior genetics. The contributions fully warrant serious consideration by psychologists, although many who believe that psychology needs to take into account the kinds of organism we are dealing with will not be impressed by the degree of progress represented among them. The concern is that the fancy of psychologists will not be caught by such volumes, and that they may incline toward dismissing out of hand all genetic studies of behavior. Where does such a discipline go? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - human behavior genetics
KW  - psychologists
KW  - 1969
KW  - Behavioral Genetics
KW  - Psychologists
KW  - 1969
U2  - Vandenberg, Steven G. (Ed). (1968); Progress in Human Behavior Genetics: Recent Reports on Genetic Syndromes, Twin Studies, and Statistical Advances; Baltimore: Johns Hopkins Press, 1968. Pp. xi + 356. $12.50
DO  - 10.1037/009820
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Newman, S. J.;
AU  - Sever, J. L.;
AU  - Fuccillo, D. A.;
T1  - Intranasal administration of HPV-77 rubella vaccine grown in WI-38. Lack of infection by this route
CT  - Intranasal administration of HPV-77 rubella vaccine grown in WI-38. Lack of infection by this route
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1969/09/27/
VL  - 2
IS  - Sep 27
SP  - 665
EP  - 666
SN  - 00237507
AD  - Perinatal Research Branch, Section on Infectious Diseases, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3863; Language: English; References: 7; Journal Coden: LANCAO; Section Heading: Drug Evaluations; Abstract Author: Lamar Orr
N2  - The HPV-77/WI 6 strain of rubella virus was administered intranasally to 4 susceptible adult males without producing a rise in hemagglutination-inhibiting antibody titer. The results suggest that this particular strain does not produce antibodies when given intranasally. At the same time, the lack of infectivity by this route supports the safety and noncommunicability of this attenuated rubella virus when administered parenterally to susceptible children. The ease of administration by this method, as well as the lack of spread to contact, make intranasal inoculation attractive for future study.
KW  - Rubella vaccines--HPV-77/WI 6 strain-;
KW  - Drug administration--rubella vaccines--intranasal, HPV-77/WI 6 strain, no rise produced in hemagglutination-inhibiting antibody titer;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
AU  - Schooler, Carmi
T1  - CLASS, OCCUPATION, AND ORIENTATION.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1969/10//
VL  - 34
IS  - 5
M3  - Article
SP  - 659
EP  - 678
SN  - 00031224
AB  - <em>Social class is consistently related to men's values -- both their value: for themselves and those for their children -- and to their orientation to work, society, and self. Basic to all these class relationships is the distinction between self-direction and conformity to external authority, the former more highly valued by men of higher social class position, the hater by men of lower social class position. All these class relationships can be explained as resulting from the cumulative effects of education and occupational position. Education is import ant because it can foster the intellectual flexibility and breadth of perspective required for sell-directed values and orientation. Occupational position is important because it is determinative of the conditions that facilitate or preclude the exercise of self-direction in work</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OCCUPATIONS
KW  - INTERGROUP relations
KW  - SOCIAL classes
KW  - CLASS relations
KW  - EDUCATION
KW  - SOCIAL status
N1  - Accession Number: 12813381; Kohn, Melvin L. 1; Schooler, Carmi 1; Affiliations: 1: National Institute Of Mental Health; Issue Info: Oct69, Vol. 34 Issue 5, p659; Thesaurus Term: OCCUPATIONS; Thesaurus Term: INTERGROUP relations; Subject Term: SOCIAL classes; Subject Term: CLASS relations; Subject Term: EDUCATION; Subject Term: SOCIAL status; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 20p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Allen, Gordon
T1  - Eugenics and the Progressives (Book).
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1969/10//
VL  - 34
IS  - 5
M3  - Book Review
SP  - 810
EP  - 811
SN  - 00031224
AB  - Reviews the book "Eugenics and the Progressives," by Donald K. Pickens.
KW  - EUGENICS
KW  - NONFICTION
KW  - PICKENS, Donald K.
KW  - EUGENICS & the Progressives (Book)
N1  - Accession Number: 12813463; Allen, Gordon 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Oct69, Vol. 34 Issue 5, p810; Subject Term: EUGENICS; Subject Term: NONFICTION; Reviews & Products: EUGENICS & the Progressives (Book); People: PICKENS, Donald K.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodwin, F. K.;
AU  - Murphy, D. L.;
AU  - Bunney, W. E.;
T1  - Lithium carbonate treatment in depression and mania
CT  - Lithium carbonate treatment in depression and mania
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1969/10/01/
VL  - 21
IS  - Oct
SP  - 486
EP  - 496
AD  - National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-1807; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 40; Journal Coden: ARGPAQ; Section Heading: Investigational Drugs; Abstract Author: Harold N. Godwin
N2  - In a controlled longitudinal study, 12 manic and 18 depressed patients were studied to evaluate lithium carbonate used for both mania or depression. Therapeutic results were obtained in 9 of the 12 mania patients studied. Only 5 of the 18 depressed patients showed complete remission of symptoms while on lithium carbonate. It was concluded that lithium carbonate should not be considered an antidepressant but further investigation should be conducted.
KW  - Lithium carbonate--depression and mania-;
KW  - Psychotherapeutic agents--lithium carbonate;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Haskell, C. M.;
AU  - Canellos, G. P.;
T1  - (-)-Asparaginase resistance in human leukemia--asparagine synthetase
CT  - (-)-Asparaginase resistance in human leukemia--asparagine synthetase
JO  - Biochem. Pharmacol.
JF  - Biochem. Pharmacol.
Y1  - 1969/10/01/
VL  - 18
IS  - Oct
SP  - 2578
EP  - 2580
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-0463; Language: English; Chemical Name: Asparagine--7006-34-0 Asparaginase--9015-68-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents asparaginase; References: 13; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: A. Leon Moore
N2  - This is a study of asparagine synthetase levels in 18 patients with leukemia who were subsequently treated with (-)-asparaginase, 200 I.U./kg., in order to determine whether this enzyme may play a role in human leukemic cell resistance to (-)-asparaginase. The level of asparagine synthetase in leukemic cells was nearly undetectable prior to therapy regardless of subsequent response to (-)-asparaginase treatment. The 4 patients in whom an antileukemic effect occurred had no change in asparagine synthetase with therapy; however, there was a sevenfold increase in the mean level of asparagine synthetase in the 5 patients who were unresponsive to treatment. The difference between asparagine synthetase levels in the sensitive and resistant patients, determined during or after (-)-asparaginase, was highly significant. It was concluded from this data that (-)-asparaginase resistance in human leukemic cells is at least in part related to the capacity for (-)-asparagine biosynthesis via asparagine synthetase.
KW  - Asparagine--synthetase-;
KW  - Asparaginase--effect on asparagine synthetase levels-;
KW  - Antineoplastic agents--asparaginase--effect, on asparagine synthetase in leukemia patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Heine, U.;
T1  - Electron microscopic studies on Hela cells exposed to the antibiotic toyocamycin
CT  - Electron microscopic studies on Hela cells exposed to the antibiotic toyocamycin
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/10/01/
VL  - 29
IS  - Oct
SP  - 1875
EP  - 1880
SN  - 00085472
AD  - Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-0946; Language: English; Chemical Name: Toyocamycin--606-58-6; Therapeutic Class: (8:12); AHFS Class: Antibiotics toyocamycin; References: 28; Journal Coden: CNREA8; Section Heading: Pharmacology; Abstract Author: Jimmie L. Hall
N2  - This report describes the changes in cellular ultramorphology induced by various doses of toyocamycin. In low concentrations toyocamycin selectively induces an enlargement of the pars fibrosa in the nucleolus. High concentrations provoke morphologic changes similar to those observed with dactinomycin.
KW  - Toyocamycin--morphological effects-;
KW  - Antibiotics--toyocamycin--morphological effects on Hela cells;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-41057-009
AN  - 2013-41057-009
AU  - Shore, Milton F.
AU  - Massimo, Joseph L.
T1  - Five years later: A followup study of comprehensive vocationally oriented psychotherapy.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1969/10//
VL  - 39
IS  - 5
SP  - 769
EP  - 773
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Clinical Research and Program Evaluation Section, Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-41057-009. PMID: 5348784 Partial author list: First Author & Affiliation: Shore, Milton F.; Clinical Research and Program Evaluation Section, Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Occupational Guidance; Psychotherapy. Minor Descriptor: Development; Employment Status; Juvenile Delinquency. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 1969. 
AB  - This is the second in a continuing series of followup studies of adolescent delinquent boys successfully treated in an experimental program five years ago. Few legal difficulties, stable employment, and personal growth were shown in those treated. On the other hand, three of the untreated youth were in adult correctional institutions, employment was irregular, personal rewards few. Contact with usual rehabilitative agents of society seemed unable to reverse the deterioration in the untreated group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adolescent delinquency
KW  - stable employment
KW  - personal growth
KW  - vocational psychotherapy
KW  - 1969
KW  - Occupational Guidance
KW  - Psychotherapy
KW  - Development
KW  - Employment Status
KW  - Juvenile Delinquency
KW  - 1969
DO  - 10.1111/j.1939-0025.1969.tb00658.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41057-011
AN  - 2013-41057-011
AU  - Jacobson, Gary
AU  - Ryder, Robert G.
T1  - Parental loss and some characteristics of the early marriage relationship.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1969/10//
VL  - 39
IS  - 5
SP  - 779
EP  - 787
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Jacobson, Gary, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US, 02114
N1  - Accession Number: 2013-41057-011. PMID: 5348786 Partial author list: First Author & Affiliation: Jacobson, Gary; Family Development Section, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Interpersonal Interaction; Marriage; Parental Death; Trust (Social Behavior). Minor Descriptor: Pathology. Classification: Group & Interpersonal Processes (3020). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 1969. 
AB  - People who had experienced the final disruption of a previous fundamental relationship through the death of a parent were studied in the first few years of their marriage. The results contribute to the understanding not only of pathological issues in marriage such as the inability to maintain trust or resolve anger but also of nonpathological issues such as interpersonal closeness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - parental loss
KW  - marriage relationship
KW  - pathological issues
KW  - interpersonal closeness
KW  - trust
KW  - 1969
KW  - Interpersonal Interaction
KW  - Marriage
KW  - Parental Death
KW  - Trust (Social Behavior)
KW  - Pathology
KW  - 1969
DO  - 10.1111/j.1939-0025.1969.tb00660.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gallelli, J. F.;
AU  - MacLowry, J. D.;
AU  - Skolaut, M. W.;
T1  - Stability of antibiotics in parenteral solutions
CT  - Stability of antibiotics in parenteral solutions
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1969/11/01/
VL  - 26
IS  - Nov
SP  - 630
EP  - 635
SN  - 00029289
AD  - Pharmacy Department, The Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0933; Language: English; Chemical Name: Ampicillin--69-53-4 Carbenicillin--4697-36-3 Cephaloridine--50-59-9 Chloramphenicol--56-75-7 Erythromycin--114-07-8 Gentamicin--1403-66-3 Kanamycin--59-01-8 Methicillin--61-32-5 Nafcillin--147-52-4 Oleandomycin--3922-90-5 Penicillin G--61-33-6 Tetracycline--60-54-8 Vancomycin--1404-90-6 Cephalothin--153-61-7 Lincomycin--154-21-2; References: 2; Journal Coden: AJHPA9; Section Heading: Drug Stability; Microbiology
N2  - Stability studies involving 16 antibiotics used in parenteral solutions were conducted to determine their antimicrobial potency and duration of activity after preparation. The drugs used in the studies were ampicillin sodium, carbenicillin disodium, cephaloridine, cephalothin sodium, chloramphenicol, colistimethate sodium, erythromycin lactobionate, gentamicin sulfate, kanamycin sulfate, lincomycin hydrochloride, methicillin sodium, nafcillin sodium, oleandomycin phosphate, penicillin G potassium buffered, tetracycline hydrochloride and vancomycin hydrochloride. All studies were conducted at 25DG C. and 5DG C. Sample solutions were assayed microbiologically, visually inspected and the pH recorded over a period of 2 months. All antibiotics except ampicillin sodium retained their initial antimicrobial activity for a minimum of one month at 5DGC. in both normal saline and dextrose 5% in water. The antimicrobial activity of 5 antibiotics (ampicillin sodium, cephalothin sodium, nafcillin sodium, penicillin G potassium buffered and tetracycline hydrochloride) at 25DG C. varied considerably depending upon which vehicle was used. With the exception of methicillin sodium solutions, it was impossible to correlate change in pH with decrease in activity of the sample solutions. Although physical changes were observed in 7 antibiotics studied--ampicillin sodium, cephaloridine, cephalothin sodium, chloramphenicol, nafcillin sodium, tetracycline hydrochloride and vancomycin hydrochloride--all except the dextrose solutions of ampicillin showed no decrease in activity at 5DG C. up to 60 days.
KW  - Ampicillin--sodium-;
KW  - Carbenicillin--disodium-;
KW  - Cephaloridine--stability-;
KW  - Chloramphenicol--stability-;
KW  - Erythromycin--lactobionate-;
KW  - Gentamicin--sulfate-;
KW  - Kanamycin--sulfate-;
KW  - Methicillin--sodium-;
KW  - Nafcillin--sodium-;
KW  - Oleandomycin--phosphate-;
KW  - Penicillin G--potassium-;
KW  - Tetracycline--hydrochloride-;
KW  - Vancomycin--hydrochloride-;
KW  - Cephalothin--sodium-;
KW  - Colistimethate--sodium-;
KW  - Lincomycin--hydrochloride-;
KW  - Injections--antibiotics--stability, parenteral solutions;
KW  - Antibiotics--stability--parenteral solutions;
KW  - Stability--antibiotics--parenteral solutions;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0933&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lewis, J. L., Jr.;
AU  - Davis, R. C.;
AU  - Parker, J. T.;
T1  - Modification of the immunologic response to human choriocarcinoma in the hamster cheek pouch by heterologous antilymphocyte serum
CT  - Modification of the immunologic response to human choriocarcinoma in the hamster cheek pouch by heterologous antilymphocyte serum
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/11/01/
VL  - 29
IS  - Nov
SP  - 1988
EP  - 1994
SN  - 00085472
AD  - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-1684; Language: English; Chemical Name: Methotrexate--59-05-2 Antilymphocyte serum--0; References: 25; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology
N2  - This article compares the response to methotrexate of tumors growing in the pouch of antilymphocyte serum-treated hamsters with that in control animals not undergoing immunosuppression. Methotrexate had less antineoplastic effect on choriocarcinoma in antilymphocyte serum-treated hamsters than in the untreated.
KW  - Methotrexate--antineoplastic effect-;
KW  - Antilymphocyte serum--treated hamsters-;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1684&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Liegler, D. G.;
AU  - Henderson, E. S.;
AU  - Hahn, M. A.;
AU  - Oliverio, V. T.;
T1  - Effect of organic acids on renal clearance of methotrexate in man
CT  - Effect of organic acids on renal clearance of methotrexate in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1969/11/01/
VL  - 10
IS  - Nov-Dec
SP  - 849
EP  - 857
SN  - 00099236
AD  - Laboratory of Chemical Pharmacology and Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-2146; Language: English; Chemical Name: Methotrexate--59-05-2; References: 25; Journal Coden: CLPTAT; Section Heading: Drug Metabolism and Body Distribution
N2  - The renal clearance of methotrexate was compared with that of inulin and para-aminohippurate in 15 patients with disseminated malignancy. The clearance of methotrexate exceeded that of inulin clearance in all cases, indicating methotrexate is not only filtered but is also actively secreted by the renal tubules. The simultaneous intravenous administration of weak organic acids resulted, generally, in suppressive effects on the clearance of methotrexate. Salicylate and high concentrations of para-aminohippurate reduced methotrexate clearance well below the glomerular filtration rate; whereas, sulfisoxazole had only a minimal effect on total methotrexate clearance. The variations of plasma protein binding of methotrexate induced by these same drugs did not correlate with the direction or degree of methotrexate clearance. It is concluded from these studies that methotrexate is excreted by a combination of glomerular filtration and active tubular transport and that methotrexate clearance is not directly related to the level of free methotrexate presented to the kidneys. It is furthermore suggested that the alterations in plasma protein binding and renal clearance of methotrexate provoked by the simultaneous administration of other organic acids may be clinically exploitable in cancer chemotherapy.
KW  - Methotrexate--excretion-;
KW  - Acids--organic--effects, on renal clearance of methotrexate;
KW  - Excretion--methotrexate--renal clearance, effect of organic acids;
KW  - Metabolism--methotrexate--renal clearance, effect of organic acids;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2146&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gordon, J. B.;
T1  - Politics of community Medicine projects
CT  - Politics of community Medicine projects
JO  - Medical Care (USA)
JF  - Medical Care (USA)
Y1  - 1969/11/01/
VL  - 7
IS  - Nov-Dec
SP  - 419
EP  - 428
SN  - 00257079
AD  - Public Health Service, National Institutes of Health, Room 2A32, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 7-3327; Language: English; References: 32; Journal Coden: MDLCBD; Section Heading: Sociology, Economics and Ethics
N2  - The community health center is a new institution which has been promoted by the Office of Economic Opportunity to provide health service to the poor, to establish an alternate model for medical practice, and to help reintegrate the poor into the mainstream of society. Among the barriers to the success of this innovation has been a lack of political realism on the part of many of the participants. A sociological analysis of the process of project evolution demonstrating the many opportunities for controversy and conflict to develop, is presented. Inferences from conflict theory are presented to show how a sophisticated approach to controversy can expedite social change. If health professionals, including pharmacists, are to be involved in the wide range of social and physical ills of their patients they must be familiar with these strategies.
KW  - Sociology--health care--centers, community participants lack political realism;
KW  - Pharmacists--health care--centers, community need for political realism if center to succeed;
KW  - Health care--centers--community, success dependent upon political realism by participants;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3327&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Tjio, J.-H.;
AU  - Pahnke, W. N.;
AU  - Kurland, A. A.;
T1  - LSD and chromosomes. A controlled experiment
CT  - LSD and chromosomes. A controlled experiment
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1969/11/03/
VL  - 210
IS  - Nov 3
SP  - 849
EP  - 856
AD  - National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Maryland 20014
AD  - reprints: Maryland Psychiatric Research Center, Box 3235, Baltimore, Maryland 21228
N1  - Accession Number: 7-1404; Language: English; Trade Name: LSD; Generic Name: Lysergic acid diethylamide; References: 27; Journal Coden: JAMAAP; Section Heading: Pharmacology
N2  - The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD). Double-blind, controlled research of the effects of the drug in psychotherapy and in 5 black market LSD users who volunteered to take pure LSD in a research setting is reported. Statistical analysis revealed no significant difference between the before- and after-LSD chromosomal aberration rates. In addition, a post-LSD study of 8 normal subjects who had received LSD in previous research experiments was also performed with the same cytogenetic methods. The results of these experiments consistently supported the conclusion that at this time there is no definite evidence that pure LSD damages chromosomes of human lymphocytes in vivo as studied from 72-hour cultures.
KW  - Lysergic acid diethylamide--toxicity studies-;
KW  - Toxicity studies--lysergic acid diethylamide--conclusion of no definite evidence of damage to chromosomes of human lymphocytes in vivo;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1404&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Haskell, C. M.;
AU  - Canellos, G. P.;
AU  - Leventhal, B. G.;
AU  - Carbone, P. P.;
AU  - Block, J. B.;
AU  - et al;
T1  - L-Asparaginase: therapeutic and toxic effects in patients with neoplastic disease
CT  - L-Asparaginase: therapeutic and toxic effects in patients with neoplastic disease
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1969/11/06/
VL  - 281
IS  - Nov 6
SP  - 1028
EP  - 1034
SN  - 00284793
AD  - reprints: National Cancer Institute, Bldg. 10/12-N-226, Bethesda, Maryland 20014
N1  - Accession Number: 7-3393; Language: English; Trade Name: NSC-109229; Generic Name: Asparaginase; Chemical Name: Asparaginase--9015-68-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents asparaginase; References: 38; Journal Coden: NEJMAG; Section Heading: Investigational Drugs; Pharmacology
N2  - Escherichia coli L-asparaginase (NSC-109229) was administered to 55 patients; two thirds of the patients received 200 I.U./kg./day but others received doses ranging from 50 to 2000 I.U./kg./day. Responses were restricted to a patient with melanoma, 4 patients with lymphoma and 11 patients with leukemia. The complete remission rate was 26% in patients with acute lymphatic leukemia, with a median remission duration of 9 weeks. Most patients tolerated L-asparaginase; however, severe toxicity appeared in a variety of forms. Hypersensitivity occurred in 14 of the patients. Depression of clotting factors occurred in 16 of 20 evaluable patients, liver dysfunction in 33 of 35 evaluable patients, central nervous system disturbances in 18 of 35 evaluable adults (but none of the children), pancreatitis in 6 patients, and renal failure in 2 patients.
KW  - Asparaginase--toxicity studies-;
KW  - Toxicity studies--asparaginase--in patients with neoplastic diseases;
KW  - Antineoplastic agents--asparaginase--toxicity studies;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3393&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Epstein, E. H., Jr.;
AU  - Lutzner, M. A.;
T1  - Folliculitis induced by actinomycin D
CT  - Folliculitis induced by actinomycin D
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1969/11/13/
VL  - 281
IS  - Nov 13
SP  - 1094
EP  - 1096
SN  - 00284793
AD  - reprints: Building 10, Room 12N238, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3372; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents dactinomycin; References: 11; Journal Coden: NEJMAG; Section Heading: Toxicity
N2  - In 9 of 11 adult patients treated with actinomycin D (dactinomycin) a characteristic skin eruption developed, with predictable progression from erythema to papules and pustules and from face to trunk. The dominant histologic feature of these lesions was initial replacement of the hair follicles and sebaceous glands with neutrophils. After resolution of the inflammation, plugged, dilated follicles persisted for several months. Although often dramatic and unsightly, this eruption was benign and required no modification of treatment.
KW  - Dactinomycin--toxicity-;
KW  - Toxicity--dactinomycin--folliculitis;
KW  - Antineoplastic agents--dactinomycin--toxicity, folliculitis;
KW  - Drugs, adverse reactions--dactinomycin--folliculitis;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3372&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Zaharko, D. S.;
AU  - Bruckner, H.;
AU  - Oliverio, V. T.;
T1  - Antibiotics alter methotrexate metabolism and excretion
CT  - Antibiotics alter methotrexate metabolism and excretion
JO  - Science
JF  - Science
Y1  - 1969/11/14/
VL  - 166
IS  - Nov 14
SP  - 887
EP  - 888
AD  - Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-3666; Language: English; Chemical Name: Sulfathiazole--72-14-0 Methotrexate--59-05-2 Neomycin--1404-04-2; References: 10; Journal Coden: SCIEAS; Section Heading: Drug Interactions
N2  - Methotrexate is metabolized by the intestinal flora of normal mice. This metabolism in normal mice is reduced by treatment with neomycin and sulfathiazole. The same is true in germ-free mice. In addition to affecting metabolism, neomycin and sulfathiazole alter physiological distribution of methotrexate so that excretion by the intestinal route is significantly enhanced.
KW  - Sulfathiazole--and neomycin-;
KW  - Methotrexate--metabolism-;
KW  - Neomycin--and sulfathiazole-;
KW  - Drug interactions--methotrexate--metabolism and excretion altered by neomycin and sulfathiazole, in mice;
KW  - Metabolism--methotrexate--reduction, by neomycin and sulfathiazole, in mice;
KW  - Drugs, body distribution--methotrexate--altered by neomycin and sulfathiazole;
KW  - Excretion--methotrexate--intestinal, enhanced by neomycin and sulfathiazole;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3666&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levine, P. H.;
AU  - Hamstra, R. D.;
T1  - Megaloblastic anemia of pregnancy simulating acute leukemia
CT  - Megaloblastic anemia of pregnancy simulating acute leukemia
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1969/12/01/
VL  - 71
IS  - Dec
SP  - 1141
EP  - 1147
SN  - 00034819
AD  - Viral Leukemia and Lymphoma Branch, Bldg. 37, Rm 1-A-15, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-2782; Language: English; Chemical Name: Iron--7439-89-6; References: 16; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2  - Two patients had megaloblastic anemia of pregnancy, presenting with histories and bone marrow smears compatible with acute granulocytic leukemia. A review of the reported cases of acute leukemia in pregnancy indicates the difficulty in making a definite diagnosis on the basis of clinical history and smears of the blood and bone marrow. The role of concurrent iron deficiency in obscuring the diagnosis of megaloblastic anemia is suggested. A brief trial of folic acid and vitamin B12 (cyanocobalamin) is indicated in all patients with equivocal marrow findings or the possibility of vitamin deficiency.
KW  - Iron--deficiency-;
KW  - Anemias--megaloblastic--of pregnancy, simulating acute leukemia;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2782&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ryan, J. J.;
AU  - Ketcham, A. S.;
AU  - Wexler, H.;
T1  - Warfarin therapy as an adjunct to the surgical treatment of malignant tumors in mice
CT  - Warfarin therapy as an adjunct to the surgical treatment of malignant tumors in mice
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2191
EP  - 2194
SN  - 00085472
AD  - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-2987; Language: English; Chemical Name: Warfarin--81-81-2; References: 21; Journal Coden: CNREA8; Section Heading: Pharmacology; Drug Evaluations
N2  - This study is an assessment of warfarin anticoagulation as an adjunct to the surgical removal of malignant tumors in mice. Warfarin anticoagulation throughout the pre-, intra-, and early postoperative periods significantly improved the long-term survival and the cure rate of mice following amputation of a tumor bearing limb. The level of anticoagulation producing this effect was not excessive, with the prothrombin time prolonged between 2.8 and 3.5 times the normal, average value. Deaths from complications were increased in the warfarin-treated mice, but not nearly to the extent that deaths with metastatic disease were reduced. The mechanism by which warfarin influences primary tumor growth and metastatic spread is not clear. Hopefully, anticoagulation may be of practical value in the treatment of malignant disease in humans.
KW  - Warfarin--anticoagulation-;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2987&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Henderson, E. S.;
AU  - Samaha, R. J.;
T1  - Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies
CT  - Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2272
EP  - 2280
SN  - 00085472
AD  - Leukemia Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3458; Language: English; References: 54; Journal Coden: CNREA8; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Jimmie L. Hall
N2  - This paper discusses the following question: Is combination chemotherapy superior to single drug therapy in the treatment of cancer? In general, combination therapy is indicated only if the disease does not regularly respond to any single form of treatment, but can be modified by 2 or more agents. A number of published studies which compare combination with single drug therapy are reviewed.
KW  - Drugs--combined therapy--cancer, comparison with single drug therapy;
KW  - Antineoplastic agents--cancer--combined vs. single drug therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3458&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Zubrod, C. G.;
T1  - Summary of informal discussion on clinical cancer chemotherapy today
CT  - Summary of informal discussion on clinical cancer chemotherapy today
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2284
SN  - 00085472
AD  - National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-2997; Language: English; Journal Coden: CNREA8; Section Heading: Pharmacology
KW  - Cancer--chemotherapy--clinical, summary of informal discussion;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2997&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goldin, A.;
T1  - Factors pertaining to complete drug-induced remission of tumors in animals and man
CT  - Factors pertaining to complete drug-induced remission of tumors in animals and man
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2285
EP  - 2291
SN  - 00085472
AD  - Cancer Chemotherapy National Service Center, Chemotherapy, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-3457; Language: English; References: 41; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - This article discusses factors that prevent an antineoplastic agent from inducing a complete remission. A complete remission involves the elimination or the control of growth of the tumor cell population, and is subject to a balance of factors pertaining to drug, tumor, and host. The major limiting factor in antineoplastic therapy is the toxicity of the drug to the host. Other factors which may influence the attainment of complete remission are the extent of action of the drug on the tumor cells, the degree of challenge represented by the number of tumor cells, the origin and extent of tumor cell resistance, the degree of sequestration of the tumor cells, and the pharmacologic and immunologic status of the host.
KW  - Antineoplastic agents--remission of tumors--factors preventing;
KW  - Toxicity--antineoplastic agents;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3457&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Perry, S.;
T1  - Reduction of toxicity in cancer chemotherapy
CT  - Reduction of toxicity in cancer chemotherapy
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2319
EP  - 2325
SN  - 00085472
AD  - National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-2479; Language: English; References: 57; Journal Coden: CNREA8; Section Heading: Toxicity; Pharmacology; Abstract Author: Jimmie L. Hall
N2  - This paper reviews the current status of the supportive care of patients undergoing treatment with the antineoplastic agents. The most serious complications of cancer chemotherapy are the thrombocytopenia and leukopenia caused by bone marrow depression. Platelet replacement by transfusion is now generally recognized to be valuable in preventing or controlling the hemorrhage due to thrombocytopenia. Leukocyte replacement, however, is not yet a practical procedure, and leukopenia often allows bacterial or fungal infections to overwhelm the patient. Antibiotics are of limited value in this situation. Patient isolation and protection, as by laminar air flow rooms, are one means of reducing this infection hazard. Toxicity to the bone marrow or to the gastrointestinal tract may preclude administration of the antineoplastic drug in doses adequate to obtain optimum tumor cell kill. Other complications of antineoplastic agents include nausea, vomiting, diarrhea, constipation, chemical cystitis, muscle weakness, hepatotoxicity, alopecia, peripheral neuropathy, and urate neuropathy.
KW  - Antineoplastic agents--toxicity--in cancer chemotherapy, reduction;
KW  - Toxicity--antineoplastic agents--in cancer chemotherapy, reduction;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2479&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rall, D. P.;
T1  - Summary of informal discussion on the design of more selective antitumor agents
CT  - Summary of informal discussion on the design of more selective antitumor agents
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2407
SN  - 00085472
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3237; Language: English; Journal Coden: CNREA8; Section Heading: Pharmacology
KW  - Antineoplastic agents--development--design of more selective agents;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3237&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lipsett, M. B.;
T1  - Prospects in endocrinology for chemotherapy
CT  - Prospects in endocrinology for chemotherapy
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2408
EP  - 2411
SN  - 00085472
AD  - Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-3238; Language: English; Journal Coden: CNREA8; Section Heading: Pharmacology
KW  - Chemotherapy--prospects in endocrinology;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3238&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rall, D. P.;
T1  - New approaches in administration of anticancer drugs
CT  - New approaches in administration of anticancer drugs
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1969/12/01/
VL  - 29
IS  - Dec
SP  - 2471
EP  - 2474
SN  - 00085472
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-2786; Language: English; References: 5; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - This paper analyzes some of the factors which appear to be important in the successful chemotherapy of certain tumors and applies these factors to the important tumors thus far resistant to chemotherapy.
KW  - Antineoplastic agents--administration--new approaches;
KW  - Drug administration--antineoplastic agents--new approaches;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2786&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2009-11544-003
AN  - 2009-11544-003
AU  - Yolles, Stanley F.
T1  - Foreword.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1969///Win 1969
VL  - 1
IS  - 1
SP  - 3
EP  - 3
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11544-003. Partial author list: First Author & Affiliation: Yolles, Stanley F.; National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Information Dissemination; Printed Communications Media; Schizophrenia; Scientific Communication. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 1. Issue Publication Date: Win 1969. 
AB  - Schizophrenia is the most prevalent and incapacitating of the major mental illnesses. For the past two decades the National Institute of Mental Health has supported a broad program of research and training directed toward the understanding and control of this complex disorder. The Schizophrenia Bulletin is one manifestation of the Institute's concern with the need to stimulate interest in the problems posed by schizophrenia. By providing a broad overview of schizophrenia the Bulletin will further the evolution of a coordinated approach to this recalcitrant disorder. The Bulletin will also help facilitate the interchange and dissemination of information in this active field. It is designed therefore to serve a wide audience of lay and professional persons who are concerned with the vast, and often perplexing, issues presented by schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Schizophrenia Bulletin
KW  - schizophrenia research
KW  - information exchange & dissemination
KW  - 1969
KW  - Information Dissemination
KW  - Printed Communications Media
KW  - Schizophrenia
KW  - Scientific Communication
KW  - 1969
DO  - 10.1093/schbul/1.1.3
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11544-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-11544-001
AN  - 2009-11544-001
AU  - Rosenthal, David
T1  - Problems of sampling and diagnosis in the major twin studies of schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1969///Win 1969
VL  - 1
IS  - 1
SP  - 11
EP  - 26
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11544-001. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, Division of Clinical, Behavioral, and Biological Research, Intramural Research Program, National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article; Reprint. Language: English. Major Descriptor: Experimentation; Genetics; Schizophrenia; Twins. Minor Descriptor: Diagnosis; Sampling (Experimental). Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 16. Issue Publication Date: Win 1969. 
AB  - This reprinted article originally appeared in the Journal of Psychiatric Research, Vol 1(2), 1962, 116-134. (The following abstract of the original article appeared in record [rid]1964-09069-001[/rid].) Problems of sampling and diagnosis in the 5 major twin studies of schizophrenia are critically reviewed. The main pitfalls and inconsistencies between the studies are indicated, and recommendations are made regarding methods of handling these problems. It is pointed out that despite their difficulties and errors, the twin studies probably have contributed our most reliable data regarding the inheritance of schizophrenia. On the basis of this review, one could conclude that the proportion of the variance contributed by heredity with respect to those disorders called schizophrenic is probably less than some have alleged, and that we may only now be at the point of being able to expand our knowledge of these matters in a heuristically important way. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - twins
KW  - schizophrenia studies
KW  - sampling & diagnosis problems
KW  - psychoses
KW  - 1969
KW  - Experimentation
KW  - Genetics
KW  - Schizophrenia
KW  - Twins
KW  - Diagnosis
KW  - Sampling (Experimental)
KW  - 1969
DO  - 10.1093/schbul/1.1.11
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11544-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-11544-005
AN  - 2009-11544-005
AU  - Pollin, William
AU  - Stabenau, James R.
AU  - Allen, Martin G.
T1  - Schizophrenia and adult stature: The absence of a relationship in a sample of 16,000 pairs of male twins.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1969///Win 1969
VL  - 1
IS  - 1
SP  - 40
EP  - 41
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11544-005. Partial author list: First Author & Affiliation: Pollin, William; Section on Twin and Sibling Studies, Adult Psychiatry Branch, Clinical Investigations, Intramural Research Program, National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Body Size; Body Weight; Monozygotic Twins; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 2. Issue Publication Date: Win 1969. 
AB  - Several recent studies have reported a relationship between low birth weight and the appearance of schizophrenia in studies of identical twins, and same-sexed siblings discordant for schizophrenia. Possible psychodynamic and biologic mechanisms, which might account for this relationship, have been suggested. Other investigators, however, working with different samples, have reported negative findings with respect to such a birth weight/schizophrenia relationship. In view of these discrepant results, and the paucity of reports dealing with possible relationships between adult size and weight on the one hand, and schizophrenia on the other, we examined the data available in the National Research Council's Veteran Twin Registry concerning this relationship. There was no significant difference between the mean height or weight of the group of index twins (those who developed schizophrenia) as compared to their non-schizophrenic cotwin controls. Similarly there was no significant difference between the number of pairs in which the index twin was the lighter or shorter at the time of induction as compared to his non-schizophrenic cotwin control. These data indicate that no simple relationship exists between adult stature and the development of schizophrenia, in this sample of monozygotic twins. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - male monozygotic twins
KW  - body size
KW  - body weight
KW  - adult stature
KW  - 1969
KW  - Body Size
KW  - Body Weight
KW  - Monozygotic Twins
KW  - Schizophrenia
KW  - 1969
DO  - 10.1093/schbul/1.1.40
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11544-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bernstein, R. S.;
AU  - Robbins, J.;
T1  - Intermittent therapy with L-thyroxine
CT  - Intermittent therapy with L-thyroxine
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1969/12/25/
VL  - 281
IS  - Dec 25
SP  - 1444
EP  - 1448
SN  - 00284793
AD  - reprints: Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3405; Language: English; Chemical Name: Thyroxine--7488-70-2; References: 19; Journal Coden: NEJMAG; Section Heading: Drug Evaluations; Pharmacology
N2  - Two athyreotic patients and 5 patients on suppressive doses of L-thyroxine (L-T4) were studied with intermittent oral therapy given as a single weekly dose. Thyroid tests were compared during intermittent therapy of 2.0 mg. weekly and during daily therapy with 0.3 mg. of L-T4. Serum thyroxine levels were significantly lower on intermittent therapy in 3 of 7 patients. Nevertheless, 5 of 5 patients showed complete suppression of 131I uptake by the thyroid gland one week after the dose of thyroxine. All patients were clinically euthyroid, and there was no difference in serum cholesterol. There were no toxic symptoms even after a single oral dose of 2.5 mg. of L-T4. Intermittent therapy proved to be an effective means of thyroid replacement.
KW  - Thyroxine--levo--;
KW  - Dosage--thyroxine--levo-, intermittent oral therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3405&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lucas, G.;
AU  - Lehrnbecher, W.;
T1  - Hydroxyurea in nasopharyngeal cancer
CT  - Hydroxyurea in nasopharyngeal cancer
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1969/12/29/
VL  - 210
IS  - Dec 29
SP  - 2397
AD  - National Institute of Mental Health, Washington, D. C.
N1  - Accession Number: 7-3859; Language: English; Chemical Name: Hydroxyurea--127-07-1; References: 3; Journal Coden: JAMAAP; Section Heading: Drug Evaluations; Abstract Author: Dale E. Johnson
N2  - The concomitant use of hydroxyurea and irradiation in nasopharyngeal cancer in one patient is reported.
KW  - Hydroxyurea--and irridiation-;
KW  - Irradiation--and hydroxyurea--concomitant use in nasopharyngeal cancer;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3859&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Wilcox, Michael
T1  - υ-Glutamyl Phosphate Attached to Glutamine-Specific tRNA.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1969/12/31/
VL  - 11
IS  - 3
M3  - Article
SP  - 405
EP  - 412
SN  - 00142956
AB  - B. subtilis Gln-tRNA formation, in vitro, involves the initial acceptance of glutamic acid by tRNAGln to form a missense Glu-tRNGln intermediate which is converted to Gln-tRNA by a subsequent amidation step, catalyzed by a specific amido-transferase, and requiring divalent cations, ATP, and L-glutamine or L-asparagine as amide donor. This reaction is associated with stoichiometric cleavage of glutamine and ATP to yield glutamic acid and Pi, respectively. Amidation proceeds via the formation of an activated intermediate which is shown to be γ-phospho-Glu-tRNAGln (P-γ-Glu-tRNAGln). P-γ-Glu-tRNAGln, bound to amido-transfcrase, is detected following incubation in the absence of amide donor. Subsequent addition of L-glutamine to the system leads to the rapid toss of the phosphate moiety from the intermediate concomitantly with the formation of Gln-tRNA, which is released from the enzyme. Consequences of the pathway, if it is duplicated in vivo, are the separation of the synthesis of glutamine destined for protein from that of free glutamine and, further, the coupling of the synthesis of the ammo acid with that, of protein. These implications are discussed with regard to their bearing on possible functions of the pathway. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUTAMYL-tRNA synthetase
KW  - GLUTAMIC acid
KW  - TRANSFER RNA
KW  - ADENOSINE triphosphate
KW  - TRANSFERASES
KW  - AMIDES
KW  - CATIONS
N1  - Accession Number: 13441939; Wilcox, Michael 1; Source Information: 1969, Vol. 11 Issue 3, p405; Subject: GLUTAMYL-tRNA synthetase; Subject: GLUTAMIC acid; Subject: TRANSFER RNA; Subject: ADENOSINE triphosphate; Subject: TRANSFERASES; Subject: AMIDES; Subject: CATIONS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - Gen
ID  - 9999-42358-000
AN  - 9999-42358-000
AU  - Derogatis, Leonard R.
AU  - Lipman, Ronald S.
AU  - Covi, Lino
AU  - Rickels, Karl
AU  - Uhlenhuth, E. H.
T1  - Symptom Distress Checklist-31
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1970///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-42358-000. Acronyms: SCL. Partial author list: First Author & Affiliation: Derogatis, Leonard R.; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States. Release Date: 20150907. Correction Date: 20151207. Instrument Type: Checklist. Test Location: Table 1, Page 166. Test Format: This 31-item measure utilizes a 4-point scale of discomfort from 'not at all' to 'extremely' with a 'not elicited' option.. Language: English. Constructs: Psychopathology; Symptom Distress; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300). 
AB  - Purpose: The purpose of the Symptom Distress Checklist-31 is to assess distress caused by symptoms of psychopathology.
AB  - Description: The Symptom Distress Checklist-31 (SCL; Derogatis et al., 1970) was developed to assess symptoms of psychopathology. The 31 items for this measure were taken from the item pool of the Symptom Distress Checklist, initially developed by Parloff, Kellman, and Frank (1954), and further amplified by Frank et al. (1957). All items are rated on a 4-point scale of discomfort from 'not at all' to 'extremely'. Although the SCL was originally developed as a patient self-rating instrument, doctors' ratings of the patients on the SCL scales may also be obtained. Doctors were instructed not to infer the presence of symptoms unless they were specifically referred to by the patient, thus, a fifth category 'not elicited' was added to the scales. Clinicians independently categorized the original 64 items of the scale into four a priori clusters: Anxiety, Depression, Anger-Hostility, and Obsessive-Compulsive-Phobic. Those items which were consistently assigned to a particular cluster by at least 70% of the raters at two sessions were retained. Thirty-one items met this criterion. The results of a Varimax rotation of a principal components matrix confirmed the 4-factor model. Using psychiatrists' ratings of anxious neurotic outpatients, analysis indicated an extremely high coincidence between the clinical clusters and the factors resulting from a Procrustes transformation on the original principal component factors, implying that the dimensions isolated here possess substantial reliability. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Anger-Hostility Factor
KW  - Anxiety Factor
KW  - Depression Factor
KW  - Factor Analysis
KW  - Obsessive-Compulsive-Phobic Factor
KW  - Symptom Distress Checklist-31
KW  - Test Development
KW  - Test Reliability
U5  - Symptom Distress Checklist-31 (SCL) [Test Development]Dimensions of outpatient neurotic pathology: Comparison of a clinical versus an empirical assessment. (AN: 1970-10813-001 from PsycINFO) Derogatis, Leonard R.; Lipman, Ronald S.; Covi, Lino; Rickels, Karl; Uhlenhuth, E. H.; Apr, 1970. Source: Journal of Consulting and Clinical Psychology. 34(2), American Psychological Association, US; Apr, 1970; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Outpatient; Location: United States; Sample: Anxious Neurotic Outpatients Keywords: Anger-Hostility Factor; Anxiety Factor; Depression Factor; Factor Analysis; Obsessive-Compulsive-Phobic Factor; Symptom Distress Checklist-31; Test Development; Test Reliability; Subjects: Anger; Anxiety; Checklist (Testing); Distress; Factor Structure; Hostility; Major Depression; Obsessive Compulsive Disorder; Phobias; Psychological Assessment; Psychopathology; Symptom Checklists; Test Construction; Test Forms; Test Reliability;
DO  - 10.1037/t42358-000
L3  - Full; Full text; 999942358_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-42358-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
TY  - GEN
AU  - Herman, L. G.;
T1  - Critical evaluation of microbiological hazards associated with the pharmacy and the hospital
CT  - Critical evaluation of microbiological hazards associated with the pharmacy and the hospital
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1970/01/01/
VL  - 27
IS  - Jan
SP  - 56
EP  - 60
SN  - 00029289
AD  - Environmental Services Branch, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-0788; Language: English; References: 11; Journal Coden: AJHPA9; Section Heading: Environmental Toxicity; Institutional Pharmacy Practice
N2  - Discussed are the human body of patients and hospital staff and such areas and systems of the hospital as the laundry, central sterile supply, water supply, air supply, pharmacy, dietary and tools and instruments as potential microbiological hazards in the hospital. The hospital pharmacist can play an important role in identifying and eliminating microbiological problems, particularly in hospitals without a full-time sanitarian or environmental microbiologist. In large institutions with trained personnel, the pharmacist can still do his part to provide a safer hospital and pharmacy environment.
KW  - Hospitals--microbiological hazards--evaluation;
KW  - Toxicity, environmental--microbiological hazards--associated with the pharmacy and the hospital, evaluation;
KW  - Pharmacy, institutional, hospital--microbiological hazards--evaluation;
KW  - Microbiology--hazards--associated with the pharmacy and the hospital, evaluation;
KW  - Pharmacists, hospital--can play role in identifying and eliminating microbiological problems;
KW  - Environment--hospitals--microbiological hazards, evaluation;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0788&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Willerson, J. T.;
AU  - Thompson, R. H.;
AU  - Hookman, P.;
AU  - Herdt, J.;
AU  - Decker, J. L.;
T1  - Reserpine in Raynaud's disease and phenomenon. Short-term response to intra-arterial injection
CT  - Reserpine in Raynaud's disease and phenomenon. Short-term response to intra-arterial injection
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/01/01/
VL  - 72
IS  - Jan
SP  - 17
EP  - 27
SN  - 00034819
AD  - National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-1110; Language: English; Chemical Name: Reserpine--50-55-5; References: 25; Journal Coden: AIMEAS; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2  - Improvement in superficial blood flow was achieved for periods of 1 day to 6 weeks in 6 of 12 patients with Raynaud's disease or Raynaud's phenomenon who received 600 mcg. of reserpine intra-arterially. In one patient, intravenous reserpine produced an objective heat-loss response that lasted 3 days but was accompanied by dizziness, nausea, vomiting and a 15 mm. Hg drop in blood pressure. Oral reserpine was ineffective in producing either subjective or objective improvement in the 2 patients studied. Abnormal esophageal peristalsis was replaced by normal motility after intra-arterial reserpine in 2 of the 5 patients studied. Whether the improvement in esophageal motility was spontaneous or was related to reserpine treatment is not clear.
KW  - Reserpine--Raynaud's disease and phenomenon-;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1110&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Baer, L.;
AU  - Durell, J.;
AU  - Bunney, W. E., Jr.;
AU  - Levy, B. S.;
AU  - Murphy, D. L.;
AU  - et al;
T1  - Sodium balance and distribution in lithium carbonate therapy
CT  - Sodium balance and distribution in lithium carbonate therapy
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1970/01/01/
VL  - 22
IS  - Jan
SP  - 40
EP  - 44
AD  - Laboratory of Clinical Science and Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 7-2577; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 44; Journal Coden: ARGPAQ; Section Heading: Pharmacology
N2  - The effect of lithium carbonate administration on 24 hour exchangeable sodium (NaE), sodium space (Na), extracellular fluid (ECF) volume, and residual sodium (NaR) was studied in 11 patients with affective disorders, primarily manic-depressive disease. Lithium carbonate administration was associated with a significant increase in 24 hour Na space and there was a trend for the ECF volume to increase and the NaR to decrease. Patients who responded clinically to lithium carbonate had a significantly greater increase in 24 hour NaE when compared to the nonresponders. No differences were noted between manic and nonmanic patients.
KW  - Lithium carbonate--sodium balance and distribution in therapy-;
KW  - Psychotherapeutic agents--lithium carbonate--sodium balance and distribution in therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2577&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - May, E. L.;
T1  - United States procedures for screening drugs. Testing for dependence liability in animals and man
CT  - United States procedures for screening drugs. Testing for dependence liability in animals and man
JO  - Bulletin on Narcotics (USA)
JF  - Bulletin on Narcotics (USA)
Y1  - 1970/01/01/
VL  - 22
IS  - Jan-Mar
SP  - 11
EP  - 17
SN  - 0007523X
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-0344; Language: English; Journal Coden: BNUNA5; Section Heading: Methodology
KW  - Dependence--methodology--tests, for liability, in animals and man;
KW  - Methodology--dependence--tests, for liability, in animals and man;
KW  - Drugs--screening--dependence, liability, tests, in animals and man;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0344&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Smith, W. W.;
AU  - Carter, S. K.;
AU  - Wilson, S. M.;
AU  - Newman, J. W.;
AU  - Cornfield, J.;
T1  - Joint lethal effects of actinomycin D and radiation in mice
CT  - Joint lethal effects of actinomycin D and radiation in mice
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/01/01/
VL  - 30
IS  - Jan
SP  - 51
EP  - 57
SN  - 00085472
AD  - Laboratory of Physiology and Chemotherapy Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0137; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents dactinomycin; References: 27; Journal Coden: CNREA8; Section Heading: Toxicity; Abstract Author: Jimmie L. Hall
N2  - These studies were primarily concerned with the effects of sublethal actinomycin D (dactinomycin) or radiation doses in mice as measured by the combined lethality of the 2 treatments separated by an interval of one hour to 4 days. Dactinomycin was administered to mice either before or after exposure to radiation to determine the lethality of the 2 treatments. In mice given dactinomycin and challenged with radiation, the high mortality attributed to the combined therapy decreased while mice given radiation then challenged with dactinomycin showed no evidence of recovery from radiation damage.
KW  - Dactinomycin--and radiation-;
KW  - Radiation--and dactinomycin--toxicity, in mice;
KW  - Toxicity--dactinomycin--and radiation, in mice;
KW  - Toxicity--radiation--and dactinomycin, in mice;
KW  - Antineoplastic agents--dactinomycin--and radiation, toxicity, in mice;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-0137&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P. S.;
AU  - Davis, R. D.;
AU  - Carter, S.;
AU  - Newman, J.;
AU  - Schein, D. R.;
AU  - et al;
T1  - Evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man
CT  - Evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1970/01/01/
VL  - 11
IS  - Jan-Feb
SP  - 3
EP  - 0
SN  - 00099236
AD  - Laboratory of Toxicology, Cancer Therapy Evaluation Branch, and Program Analysis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-2635; Language: English; References: 113; Journal Coden: CLPTAT; Section Heading: Methodology; Pharmacology
N2  - The usefulness of dogs and monkeys in predicting potential qualitative drug toxicity in man was examined retrospectively for 25 anticancer compounds of diverse chemical and functional classification. It was found that the large animal screen served to alert the physician to a significant proportion of the total spectrum of drug effects, which were encountered during the clinical use of a new toxic compound. The dog and monkey correctly predicted bone marrow depression, gastrointestinal disturbance, and hepatotoxicity for each drug producing these effects in the clinic; in the case of renal, cardiovascular, and neuromuscular toxicity, however, the large animal screen failed in each instance to predict one drug that produced these toxicities in man. The correct predictions were accomplished at the expense of a high percentage of false positives, which resulted from the necessity of using severely toxic dose levels in order to demonstrate all potential toxicities inherent in any compound. While organ system toxicity observed during an animal study can never be disregarded, it should be viewed with an understanding of certain limitations of animal toxicologic data. While toxicity may develop in man in an organ system predicted susceptible by an animal, a different specific clinical or chemical parameter may be involved. The adverse reaction may appear in man at a greater or lesser dose level or may follow a different order of appearance in relationship to the total spectrum of qualitative toxicity inherent in the compound. A table of 25 anticancer drugs appears. The NSC numbers, chemical and generic names, chemical classification, mechanism of action, route of administration, dosages, and principal toxic effects are tabulated. Sixteen tables in total appear which discuss pharmacologic parameters produced by these agents.
KW  - Antineoplastic agents--toxicity studies--usefulness of dogs and monkeys in predicting potential qualitative toxicities in man;
KW  - Toxicity studies--antineoplastic agents--usefulness of dogs and monkeys in predicting potential qualitative toxicities in man;
KW  - Methodology--toxicity studies--antineoplastic agents, usefulness of dogs and monkeys in predicting potential qualitative toxicities in man;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kannel, William B.
AU  - McNamara, Patricia M.
AU  - Feinleib, Manning
AU  - Dawber, Thomas R.
T1  - The unrecognized myocardial infarction.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1970/01//
VL  - 25
IS  - 1
M3  - Article
SP  - 75
EP  - 87
SN  - 0016867X
N1  - Accession Number: 17536913; Kannel, William B. 1; McNamara, Patricia M. 1; Feinleib, Manning 2; Dawber, Thomas R. 3; Source Information: Jan1970, Vol. 25 Issue 1, p75; Number of Pages: 13p; Illustrations: 9 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 5037
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Davis, John M
T1  - The transmission of information in psychiatry
JO  - In North, Jeanne B., Ed. The Information Conscious Society. Proceedings Of The American Society For Information Science. Volume 7. 33rd Annual Meeting, Philadelphia, October 11-15, 1970. 1970. American Society For Information Science, 1140 Connecticut Ave
JF  - In North, Jeanne B., Ed. The Information Conscious Society. Proceedings Of The American Society For Information Science. Volume 7. 33rd Annual Meeting, Philadelphia, October 11-15, 1970. 1970. American Society For Information Science, 1140 Connecticut Ave
Y1  - 1970///
M3  - Book
AB  - A content analysis was performed on time samples from the last fifty years of psychiatric journal articles. The number of articles in different categories was recording at various points during this time period, and an increase in the number of publications over this time period was found. Four content areas outside of psychiatry were chosen, containing important advances relevant to psychiatry. In all cases there was a marked time lag between the discovery of these advances outside of pschiatry and the time at which they were first frequently quoted in the psychiatric literature. The dates of publication of references listed in the bibliographies of current journals were studied. The age (when published) of the references were felt to give an index of the flow of information over time or 'metabolism' of information in the various fields. The metabolism of information in psychoanalysis and psychiatry was compared to that in psychology and physics.
N1  - Accession Number: ISTA0600262; Davis, John M 1; Affiliations: 1 : National Institute Of Mental Health, Bethesda, Maryland.;  Source Info: 1970; Note: Update Code: 0600; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jacobson, A. E.;
AU  - Mokotoff, M.;
T1  - Azabicyclo chemistry. I. Synthesis of 1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepines. B-norbenzomorphans
CT  - Azabicyclo chemistry. I. Synthesis of 1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepines. B-norbenzomorphans
JO  - J. Med. Chem.
JF  - J. Med. Chem.
Y1  - 1970/01/01/
VL  - 13
IS  - Jan
SP  - 7
EP  - 9
AD  - Laboratory of Chemistry, National Institutes of Health, Bethesda, Maryland 20014, and Department of Medicinal Chemistry, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
N1  - Accession Number: 7-0716; Language: English; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics benzazepines; References: 13; Journal Coden: JMCMAR; Section Heading: Pharmaceutical Chemistry; Pharmacology
N2  - 1,5-Methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine and its N-methyl derivative (B-norbenzomorphans) have been synthesized from 5-methoxyindan-1-one-3-acetic acid. Both compounds have analgesic activity, the former, half that of codeine, and the latter was found to be comparable to codeine.
KW  - Benzazepines--1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2---synthesis and analgesic activity;
KW  - B-Norbenzomorphans--benzazepines--1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-, synthesis and analgesic activity;
KW  - Analgesics and antipyretics--benzazepines--1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-, synthesis and analgesic activity;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Prescott, B.;
AU  - Caldes, G.;
T1  - Potential antitumor agents: derivatives of 2-hydrazino-5-nitropyridine
CT  - Potential antitumor agents: derivatives of 2-hydrazino-5-nitropyridine
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1970/01/01/
VL  - 59
IS  - Jan
SP  - 101
EP  - 104
SN  - 00223549
AD  - Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3015; Language: English; Chemical Name: Pyridine--100-86-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents pyridine; References: 9; Journal Coden: JPMSAE; Section Heading: Preliminary Drug Testing
N2  - Fifty-one hydrazones of 2-hydrazino-5-nitropyridine have been synthesized for tolerance in DBA mice and for study as potential antitumor agents against the sarcoma 180, adenocarcinoma 755, and leukemia 1210 mouse tumor systems. Of 4 compounds with activity against the sarcoma 180 tumor, 2 derivatives--p-acetaminobenzaldehyde and p-nitrobenzaldehyde--showed good inhibition and confirmed activity. The salicylaldehyde derivative showed slight activity against the adenocarcinoma 755 tumor. None of the compounds were active in the leukemia 1210 mouse tumor system. The highest tolerated dose of the active compounds in mice by I.P. injection was 2 g./kg. The compounds were thus of low toxicity. An extensive table listing chemical data for all of the synthesized components and listing antitumor activity of 4 compounds are included.
KW  - Pyridine--2-hydrazino-5-nitro--;
KW  - Hydrazones--of 2-hydrazino-5-nitropyridine--synthesized for antitumor testing;
KW  - Antineoplastic agents--pyridine--2-hydrazino-5-, derivatives, hydrazones, synthesized for antitumor testing;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - CHAP
ID  - 2004-15424-004
AN  - 2004-15424-004
AU  - Spaner, Fred E.
ED  - Korten, Frances F.
ED  - Cook, Stuart W.
ED  - Lacey, John I.
ED  - Korten, Frances F., (Ed)
ED  - Cook, Stuart W., (Ed)
ED  - Lacey, John I., (Ed)
T1  - The psychotherapist as an activist in social change: A proponent.
T2  - Psychology and the problems of society.
Y1  - 1970///
SP  - 58
EP  - 62
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2004-15424-004. Partial author list: First Author & Affiliation: Spaner, Fred E.; Community Mental Health Center Consultation Section, National Institute of Mental Health, US. Release Date: 20040719. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Conference Information: Annual Meeting of the American Psychological Association, Sep, 1969, Washington, DC, US. Conference Note: Invited Address presented to the Division of Psychotherapy at the aforementioned meeting. Major Descriptor: Activism; Psychotherapists; Social Change. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 5. 
AB  - This chapter submits that psychotherapy as a vehicle for individual change is not distinct from psychotherapy as a vehicle for social change. The author sees the psychotherapist as having an obligation to influence and promote the change process in society. The author discusses a cultural backdrop of psychotherapy and issues needing study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social change
KW  - psychotherapists
KW  - activists
KW  - 1970
KW  - Activism
KW  - Psychotherapists
KW  - Social Change
KW  - 1970
DO  - 10.1037/10042-004
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Usdin, E.;
T1  - Absorption, distribution and metabolic fate of psychotropic drugs
CT  - Absorption, distribution and metabolic fate of psychotropic drugs
JO  - Psychopharmacol. Bull.
JF  - Psychopharmacol. Bull.
Y1  - 1970/01/01/
VL  - 6
IS  - Jan
SP  - 4
EP  - 5
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, 5454 Wisconsin Avenue, Chevy Chase, Maryland 20015
N1  - Accession Number: 9-3433; Language: English; References: 62; Journal Coden: PSYBB9; Section Heading: Pharmacology; Abstract Author: Douglas L. Thompson
N2  - The principles of absorption, distribution and metabolic fate of psychotherapeutic agents are reviewed. The advantages and disadvantages of oral and parenteral routes of administration are outlined.
KW  - Absorption--drugs--principles, review;
KW  - Drugs, body distribution--principles--review;
KW  - Metabolism--drugs--principles, review;
KW  - Drug administration--routes--oral and parenteral, advantages and disadvantages;
KW  - Psychotherapeutic agents--metabolism--absorption, and body distribution, principles, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Johnson, D. E.;
AU  - Rodriquez, C. F.;
AU  - Usdin, E.;
AU  - Manian, A. A.;
AU  - Levine, J.;
T1  - Assay of chlorpromazine and some of its metabolites in urine samples
CT  - Assay of chlorpromazine and some of its metabolites in urine samples
JO  - Psychopharmacol. Bull.
JF  - Psychopharmacol. Bull.
Y1  - 1970/01/01/
VL  - 6
IS  - Jan
SP  - 44
EP  - 72
AD  - Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, 5454 Wisconsin Avenue, Chevy Chase, Maryland 20015
N1  - Accession Number: 9-4029; Language: English; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; References: 2; Journal Coden: PSYBB9; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis; Abstract Author: Douglas L. Thompson
N2  - The use of extraction and thin layer chromatographic techniques for the analysis of chlorpromazine and its metabolites in human urine are described. The method consists of 4 steps: extraction of chlorpromazine and its metabolites from urine, hydrolysis of conjugated derivatives and extraction of the aglycones, separation of the compounds by TLC, and colorimetric quantitation. A bibliography containing 389 references relating to the assay of phenothiazines and metabolites is included.
KW  - Chlorpromazine--analysis-;
KW  - Tranquilizers--chlorpromazine--analysis, TLC separation and colorimetry, in human urine;
KW  - Metabolism--chlorpromazine--analysis, in human urine, by TLC separation and colorimetry;
KW  - Colorimetry--chlorpromazine--following TLC separation, in human urine;
KW  - Chromatography, thin layer--chlorpromazine--and colorimetry, in human urine;
KW  - Phenothiazines--analysis--bibliography;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Efron, D. H.;
AU  - Manian, A. A.;
AU  - Harris, S. R.;
T1  - Simultaneous measurement of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma by radioactive derivative formation
CT  - Simultaneous measurement of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma by radioactive derivative formation
JO  - Psychopharmacol. Bull.
JF  - Psychopharmacol. Bull.
Y1  - 1970/01/01/
VL  - 6
IS  - Jan
SP  - 73
EP  - 80
AD  - Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Maryland 20015
N1  - Accession Number: 9-4030; Language: English; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; Journal Coden: PSYBB9; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
KW  - Chlorpromazine--analysis-;
KW  - Tranquilizers--chlorpromazine--base, sulfoxide and demethylated analogs, analysis, in plasma, by radioactive derivative formations;
KW  - Blood levels--chlorpromazine--base, sulfoxide and demethylated analogs, analysis, by radioactive derivative formations;
KW  - Metabolism--chlorpromazine--base, sulfoxide and demethylated analogs, analysis, by radioactive formations;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Lipkin, Lewis
T1  - Pictorial information
JO  - Science 169(3941), 166-167 (1970 July 10). 0 Ref
JF  - Science 169(3941), 166-167 (1970 July 10). 0 Ref
Y1  - 1970///
M3  - Book Chapter
AB  - A reviewq of: rosenfeld, azriel. Picture processing by computer. 1969. Academic press, new york. X + 198 p. Illus. $11.50.
N1  - Accession Number: ISTA0502626; Lipkin, Lewis 1; Affiliations: 1 : National Institutes Of Health.;  Source Info: 1970; Note: Update Code: 0500; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Smith, Margot Wiesinger
T1  - MEASURING ETHNOCENTRISM IN HILO, HAWAII: A SOCIAL DISTANCE SCALE.
JO  - Sociology & Social Research
JF  - Sociology & Social Research
Y1  - 1970/01//
VL  - 54
IS  - 2
M3  - Article
SP  - 220
EP  - 236
SN  - 00380393
AB  - The Bogardus Social Distance Scale and a personal data sheet administered to students at the University of Hawaii, Hilo Campus, yielded 356 responses - two-thirds of the students. Buddhist rural males of Japanese ancestry were found to express the most prejudices. The Social Distance Scale was not a continuum for the Hilo population. Religious preference was the best index of intensity of prejudice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Sociology & Social Research is the property of University of Southern California and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ETHNOCENTRISM
KW  - CULTURAL relativism
KW  - SOCIAL distance
KW  - SOCIAL interaction
KW  - PREJUDICES
KW  - STUDENTS
KW  - Hawaii (Hilo)
N1  - Accession Number: 17476272; Smith, Margot Wiesinger 1; Affiliations: 1 : Project coordinator, National Institute of Child Health and Human Development;  Source Info: Jan1970, Vol. 54 Issue 2, p220; Historical Period: 1970; Subject Term: ETHNOCENTRISM; Subject Term: CULTURAL relativism; Subject Term: SOCIAL distance; Subject Term: SOCIAL interaction; Subject Term: PREJUDICES; Subject Term: STUDENTS; Number of Pages: 17p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
ID  - 2013-40703-016
AN  - 2013-40703-016
AU  - Liberman, Robert
T1  - Behavorial approaches to family and couple therapy.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1970/01//
VL  - 40
IS  - 1
SP  - 106
EP  - 118
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Liberman, Robert, Saint Elizabeth's Hospital, Washington, DC, US, 20032
N1  - Accession Number: 2013-40703-016. PMID: 5410670 Partial author list: First Author & Affiliation: Liberman, Robert; Division of Special Mental Health Research, National Institute of Mental Health, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavior; Couples Therapy; Family Members; Family Therapy; Therapeutic Processes. Minor Descriptor: Goals. Classification: Group & Family Therapy (3313). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). References Available: Y. Page Count: 13. Issue Publication Date: Jan, 1970. 
AB  - Behavioral approaches to family therapy specify the problems in concrete and observable terms, empirically applying principles of learning in working toward therapeutic goals. The key to successful family therapy can be found in the changes made in the interpersonal consequences of the family members behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - behavorial approaches
KW  - family therapy
KW  - couples therapy
KW  - therapeutic goals
KW  - family members
KW  - 1970
KW  - Behavior
KW  - Couples Therapy
KW  - Family Members
KW  - Family Therapy
KW  - Therapeutic Processes
KW  - Goals
KW  - 1970
DO  - 10.1111/j.1939-0025.1970.tb00683.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Walsh, J.;
AU  - Purcell, R.;
AU  - Morrow, A.;
AU  - Chanock, R.;
AU  - Schmidt, P.;
T1  - Post-transfusion hepatitis after open-heart operations
CT  - Post-transfusion hepatitis after open-heart operations
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1970/01/12/
VL  - 211
IS  - Jan 12
SP  - 261
EP  - 265
AD  - National Institute of Allergy and Infectious Diseases Bethesda, Maryland
N1  - Accession Number: 7-4474; Language: English; References: 20; Journal Coden: JAMAAP; Section Heading: Toxicity
N2  - The incidence of icteric and anicteric hepatitis was determined prospectively in 110 patients undergoing open-heart operations in which cardiopulmonary bypass was used. Patients were supplied with blood from 2 commercial blood banks (82 patients), or from local volunteer donors (28 patients). Serial determinations of serum transaminase levels were obtained for 6 months following operation. Hepatitis developed in 51% (42) of the recipients of commercial blood, but the disease did not occur in any patient who received blood from volunteer donors. The hepatitis carrier rate for commercial blood donors was 6.3%, but, for volunteer donors, was less than 0.6%. This difference in carrier rates probably reflects differences in the donor populations.
KW  - Blood--transfusions--after open-heart operations, post-transfusion hepatitis in patients following transfusion, commercial vs. volunteer donors;
KW  - Toxicity--blood--transfusions, after open-heart operations, post-transfusion hepatitis;
KW  - Contamination--blood--in patients following transfusion, commercial vs. volunteer donors;
KW  - Hepatitis--blood--in patients following transfusion, commercial vs. volunteer donors;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Deardorff, William L.
AU  - Gerber, Paul
AU  - Vogler, William R.
T1  - Infectious Mononucleosis in Acute Leukemia with Rising Epstein-Barr Virus Antibody Titers.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1970/02//
VL  - 72
IS  - 2
M3  - Article
SP  - 235
EP  - 240
SN  - 00034819
AB  - The fourth reported case of infectious mononucleosis with onset during the course of acute leukemia and the first patient with myeloblastic leukemia in which titers to Epstein­Barr (EB) virus were found coincident with the appearance of heterophil antibodies are presented. No conclusions could be drawn as to how the course of one disease might have been affected by the other. The patient's infectious mononucleosis may have responded to antileukemic therapy. The serologic findings provide additional evidence that EB virus may cause infectious mononucleosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONONUCLEOSIS
KW  - ACUTE leukemia
KW  - EPSTEIN-Barr virus
KW  - VIRAL antibodies
KW  - DISEASES -- Causes & theories of causation
KW  - VIRUS diseases -- Treatment
N1  - Accession Number: 12539935; Deardorff, William L. 1; Gerber, Paul 1; Vogler, William R. 2; Source Information: Feb70, Vol. 72 Issue 2, p235; Subject: MONONUCLEOSIS; Subject: ACUTE leukemia; Subject: EPSTEIN-Barr virus; Subject: VIRAL antibodies; Subject: DISEASES -- Causes & theories of causation; Subject: VIRUS diseases -- Treatment; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hirschman, R. J.;
AU  - Itscoitz, S. B.;
AU  - Shulman, N. R.;
T1  - Prophylactic treatment of factor VIII deficiency
CT  - Prophylactic treatment of factor VIII deficiency
JO  - Blood
JF  - Blood
Y1  - 1970/02/01/
VL  - 35
IS  - Feb
SP  - 189
EP  - 194
AD  - Clinical Hematology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-1584; Language: English; Therapeutic Class: (16:00); AHFS Class: Blood derivatives factor VIII; References: 16; Journal Coden: BLOOAW; Section Heading: Investigational Drugs
N2  - This article describes the prophylactic treatment of factor VIII deficiency with a cryoprecipitate rich in factor VIII. Two patients with classical hemophilia, and twins with a combination of classical hemophilia and von Willebrand's disease, were treated prophylactically with cryoprecipitate for periods up to 2 years. Each had significantly fewer spontaneous hemorrhages during therapy. The prophylactic regimen required to prevent spontaneous hemorrhage was different in each case. Progressive enlargement of an inoperable hemophilic pseudotumor was arrested in one case. Complications included hepatitis in one case and occasional urticaria in another. Prophylactic treatment appears to be practical and indicated in selected cases.
KW  - Factor VIII--containing cryoprecipitate-;
KW  - Blood derivatives--factor VIII--containing cryoprecipitate, therapy, prophylactic, of factor VIII deficiency;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Coe, J.E.
T1  - The Immune Response in the Hamster II. STUDIES ON IgM.
JO  - Immunology
JF  - Immunology
Y1  - 1970/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 223
EP  - 236
SN  - 00192805
AB  - Hamster IgM has been isolated and characterized. The protein possessed unique antigenic determinants but also shared common determinants with the 7Sγ1- and 7Sγ2-globulin classes. These shared determinants were present on the F(ab')2 and Fab fragments of 7Sγ2-globulin. The rapidly sedimenting (S20,w = 20.7) IgM was dissociated into slowly sedimenting (≈ 7S) units after reduction and alkylation. Specific antibody formation in the IgM and IgG (7Sγ1-globulin) classes appeared at similar times after immunization with protein antigens, although IgM antibody was only detectable for a short period. After immunization with antigen in Freund's adjuvant, the serum concentration of IgM increased and remained at an elevated level even after disappearance of antibody to the immunizing antigen. Injection of adjuvant alone also increased the concentration of serum IgM, particularly after intraperitoneal administration of Freund's incomplete adjuvant. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN M
KW  - IMMUNE response
KW  - ANTIGENIC determinants
KW  - HAMSTERS
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGICAL adjuvants
N1  - Accession Number: 13358132; Coe, J.E. 1; Source Information: Feb70, Vol. 18 Issue 2, p223; Subject: IMMUNOGLOBULIN M; Subject: IMMUNE response; Subject: ANTIGENIC determinants; Subject: HAMSTERS; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGICAL adjuvants; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Stashak, P. W.
AU  - Baker, P. J.
AU  - Roberson, B. S.
T1  - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice I. ASSAY OF NEUTRALIZING ANTIBODY BY A 50 PER CENT NEUTRALIZATION METHOD.
JO  - Immunology
JF  - Immunology
Y1  - 1970/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 295
EP  - 305
SN  - 00192805
AB  - The experimental conditions most suitable for use in the assay of serum neutralizing antibody specific for bacteriophage φX174 by a 50 per cent neutralization method were investigated. Although assays conducted at 37° more readily revealed the presence of background neutralizing activity in the serum of non-immunized germ-free and conventionally reared mice, assays performed at 4° were more suitable for use in detecting the development of newly synthesized neutralizing antibody. In definitive experiments, the SD50 values obtained, i.e. the reciprocal of the serum dilution producing 50 per cent neutralization of added bacteriophage, were found to be directly proportional to the concentration of neutralizing antibody present in serum. The magnitude of the SD50 values obtained suggests that the procedure may be employed advantageously for the detection of very small amounts of antibody and in studies dealing with the kinetics of the antibody response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - BACTERIOPHAGES
KW  - IMMUNOGLOBULINS
KW  - MICE
KW  - IMMUNE serums
KW  - IMMUNOLOGY
N1  - Accession Number: 13358436; Stashak, P. W. 1; Baker, P. J. 2; Roberson, B. S. 3; Source Information: Feb70, Vol. 18 Issue 2, p295; Subject: IMMUNE response; Subject: BACTERIOPHAGES; Subject: IMMUNOGLOBULINS; Subject: MICE; Subject: IMMUNE serums; Subject: IMMUNOLOGY; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Stashak, P. W.
AU  - Baker, P. J.
AU  - Roberson, B. S.
T1  - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice II. KINETICS OF THE SERUM ANTIBODY RESPONSE FOLLOWING PRIMARY IMMUNIZATION.
JO  - Immunology
JF  - Immunology
Y1  - 1970/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 307
EP  - 317
SN  - 00192805
AB  - The kinetics of the serum antibody response to various amounts of bacteriophage φX174 were compared in germ-free and conventionally reared mice using a 50 per cent neutralization procedure for the assay of neutralizing antibody. Ten- and 100-fold increases in the amount of φX174 used to immunize resulted in seven and ten-fold increases, respectively, in the amount of antibody produced in conventionally reared mice; however, the same amounts of antigen produced only 1.3- and 1.9-fold increases in germ-free mice. Greater SD50 values, i.e. the reciprocal of the highest dilution of serum which neutralized 50 per cent of the added bacteriophage, were obtained in conventionally reared than germ-flee mice during the later stages of the antibody response; no other significant differences were noted in the kinetics of the response produced in both groups of animals immunized with high doses of antigen. However, neutralizing antibody was produced at a more rapid rate and in larger amounts in germ-free than conventionally reared mice immunized with a low dose of antigen. Regardless of the amount of antigen used to immunize, the time of onset of antibody formation was essentially the same (32-35 hours after injection) in both groups of mice. Conventionally reared mice eliminated antigen at half the rate observed in germ-free mice similarly immunized with high doses of φX174, but with low doses of antigen, no significant differences in elimination rate were noted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - BACTERIOPHAGES
KW  - IMMUNOGLOBULINS
KW  - MICE
KW  - IMMUNE serums
KW  - IMMUNOLOGY
N1  - Accession Number: 13358442; Stashak, P. W. 1; Baker, P. J. 2; Roberson, B. S. 3; Source Information: Feb70, Vol. 18 Issue 2, p307; Subject: IMMUNE response; Subject: BACTERIOPHAGES; Subject: IMMUNOGLOBULINS; Subject: MICE; Subject: IMMUNE serums; Subject: IMMUNOLOGY; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bischoff, K. B.;
AU  - Dedrick, R. L.;
AU  - Zaharko, D. S.;
T1  - Preliminary model for methotrexate pharmacokinetics
CT  - Preliminary model for methotrexate pharmacokinetics
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1970/02/01/
VL  - 59
IS  - Feb
SP  - 149
EP  - 154
SN  - 00223549
AD  - National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
N1  - Accession Number: 7-3297; Language: English; Chemical Name: Methotrexate--59-05-2; References: 13; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: D. R. Tousignaut
N2  - A pharmacokinetic model is presented to describe the distribution of methotrexate in mice, and the required physicochemical, anatomical, and physiological data are discussed. Methotrexate is excreted in the urine and bile; partial reabsorption occurs in the gastrointestinal tract. Observed bile concentrations were 300 times those of plasma. Models are illustrated.
KW  - Methotrexate--body distribution-;
KW  - Pharmacokinetics--methotrexate--body distribution, in mice, model presented;
KW  - Drugs, body distribution--methotrexate--pharmacokinetic model to describe body distribution, in mice;
KW  - Excretion--methotrexate--in urine and bile, partial reabsorption in gastrointestinal tract, in mice;
KW  - Models--methotrexate--body distribution, in mice;
KW  - Metabolism--methotrexate--body distribution and excretion, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Harbert, J. C.;
AU  - Fraley, E. E.;
AU  - Deckers, P. J.;
T1  - Alterations in radioactive isotope renogram pattern with urinary bladder filling
CT  - Alterations in radioactive isotope renogram pattern with urinary bladder filling
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1970/02/02/
VL  - 211
IS  - Feb 2
SP  - 810
EP  - 811
AD  - reprints: 3800 Reservoir Road, N.W., Washington, D. C. 20007
AD  - Department of Nuclear Medicine and the Surgery Branch, National Cancer Institute, Bethesda, Maryland
N1  - Accession Number: 8-0458; Language: English; Chemical Name: Iodohippurate sodium I 131--881-17-4; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals iodohippurate sodium I 131; References: 8; Journal Coden: JAMAAP; Section Heading: Pharmacology; Drug Evaluations
N2  - Patients without renal disease were examined with scintillation camera renography utilizing iodohippurate sodium I 131 with the bladder filled and then emptied. Bladder filling produces a renogram pattern of prolonged transit time which is reproducible with or without catheterization. Patients should be asked to void before radioisotope renography, especially when the patient is given a water load and when more than one study is being performed.
KW  - Iodohippurate sodium I 131--renogram pattern-;
KW  - Radiopharmaceuticals--iodohippurate sodium I 131--renogram pattern, alterations, with urinary bladder filling;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Mosher, Michael B.
T1  - Spontaneous Lactic Acidosis.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1970/03//
VL  - 72
IS  - 3
M3  - Letter
SP  - 439
EP  - 439
SN  - 00034819
AB  - Presents a letter to the editor commenting on P.P. Oliva and H.A. Schwartz's article entitled 'Survival of a Patient with Spontaneous Lactic Acidosis.'
KW  - LETTERS to the editor
KW  - ACIDOSIS
KW  - LACTIC acid
N1  - Accession Number: 12540806; Mosher, Michael B. 1; Source Information: Mar70, Vol. 72 Issue 3, p439; Subject: LETTERS to the editor; Subject: ACIDOSIS; Subject: LACTIC acid; Number of Pages: 1/6p; Document Type: Letter
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodell, B.;
AU  - Jacobs, B.;
AU  - Powell, R. D.;
AU  - DeVita, V. T.;
T1  - Pneumocystis carinii: the spectrum of diffuse interstitial pneumonia in patients with neoplastic diseases
CT  - Pneumocystis carinii: the spectrum of diffuse interstitial pneumonia in patients with neoplastic diseases
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/03/01/
VL  - 72
IS  - Mar
SP  - 337
EP  - 340
SN  - 00034819
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-2246; Language: English; Chemical Name: Pentamidine--100-33-4; Therapeutic Class: (8:00); AHFS Class: Antiprotozoals pentamidine; References: 15; Journal Coden: AIMEAS; Section Heading: Investigational Drugs; Abstract Author: Judith A. Kepler
N2  - Prospective experience and retrospective review of diffuse interstitial pneumonia in patients receiving immunosuppressive chemotherapy indicate that Pneumocystis carinii is the most common cause of this form of pneumonia. Patients with underlying malignant disease who are receiving immunosuppressive chemotherapy and who present with diffuse interstitial pneumonia should receive pentamidine isethionate as part of their antimicrobial regimen. Unless contraindicated by uncorrectable thrombocytopenia, every attempt should be made to biopsy involved areas of lung; however, therapy should not be delayed if the diagnosis cannot be confirmed by pulmonary biopsy. Although therapy with pentamidine isethionate is generally well tolerated, the drug is potentially nephrotoxic.
KW  - Pentamidine--isethionate-;
KW  - Antineoplastic agents--immunosuppressive--patients with underlying malignant disease receiving therapy who present with diffuse interstitial pneumonia, pentamidine isethionate therapy;
KW  - Antiprotozoals--pentamidine--isethionate;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Barile, M. F.;
AU  - Hardegree, M. C.;
AU  - Pittman, M.;
T1  - Immunization against neonatal tetanus in new guinea. 3. The toxin neutralization test and the response of guinea pigs to the toxoids as used in the immunization schedules in New Guinea
CT  - Immunization against neonatal tetanus in new guinea. 3. The toxin neutralization test and the response of guinea pigs to the toxoids as used in the immunization schedules in New Guinea
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1970/03/01/
VL  - 43
IS  - Mar
SP  - 453
EP  - 459
AD  - Bacterial Toxins Section, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-3024; Language: English; Language of Summary: fr; References: 12; Journal Coden: BWHOA6; Section Heading: Methodology
N2  - The mouse toxin-neutralization test procedure has been used for antitoxin titration of sera of New Guinea women following primary immunization with plain and adjuvant tetanus toxoids and following booster immunization, and for titration of guinea pig sera. The responses of guinea pigs immunized with the same toxoids and immunization schedule to simulate the human field trial studies were observed for 6 months. The relative antitoxin responses of guinea pigs to the different toxoids were similar to those of the women.
KW  - Tetanus toxoids--immunization-;
KW  - Immunization--tetanus--toxoids, against neonatal tetanus, toxin neutralization test and the response of guinea pigs to the toxoids;
KW  - Dosage forms--tetanus toxoids--plain and adjuvant, response study using mouse toxin neutralization test;
KW  - Tests--toxin neutralization--determination of response to tetanus toxoid dosage forms;
KW  - Methodology--toxin neutralization test--in tetanus toxoid immunization;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hardegree, M. C.;
AU  - Barile, M. F.;
AU  - Pittman, M.;
AU  - Maloney, C. J.;
AU  - Schofield, F.;
AU  - \ET/;
T1  - Immunization against neonatal tetanus in New Guinea. 4. Comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice
CT  - Immunization against neonatal tetanus in New Guinea. 4. Comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1970/03/01/
VL  - 43
IS  - Mar
SP  - 461
EP  - 468
AD  - Bacterial Toxins Section, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 9-3106; Language: English; Language of Summary: fr; References: 30; Journal Coden: BWHOA6; Section Heading: Methodology
N2  - Despite marked variations between passive hemagglutination and mice toxin neutralization tests the results of this study indicated that hemagglutination is a useful procedure for the overall evaluation of the antitoxin response to tetanus toxoids in field studies.
KW  - Tetanus toxoids--immunization-;
KW  - Immunization--tetanus--neonatal, comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice;
KW  - Tests--toxin neutralization--and hemagglutination, in determining tetanus antitoxin titers;
KW  - Methodology--tetanus toxoids--comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pittman, M.;
AU  - Kolb, R. W.;
AU  - Barile, M. F.;
AU  - Hardegree, M. C.;
AU  - Seligmann, E. B.;
AU  - \ET/;
T1  - Immunization against neonatal tetanus in New Guinea. 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response
CT  - Immunization against neonatal tetanus in New Guinea. 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1970/03/01/
VL  - 43
IS  - Mar
SP  - 469
EP  - 478
AD  - Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-2938; Language: English; Language of Summary: fr; References: 18; Journal Coden: BWHOA6; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2  - This report gives the details of the laboratory assays and extends the time of observation on the relationship of the international #OQ#OQunitage'' to the persistence of the protective antitoxin levels of women injected with aluminum phosphate adsorbed tetanus toxoid to 40 or 54 months after immunization. Previous papers in this series have shown that plain toxoids induced early primary antitoxin levels in women in New Guinea that were not significantly different from those induced by adsorbed toxoids but that at the end of one year the antitoxin levels differed significantly. Protective levels (not less than 0.01 unit/ml.) induced by adsorbed toxoids persisted for more than 3 years. Results of laboratory assays of the toxoids reported in this paper show that per total human immunizing dose, the plain toxoids had 72 or less international units (I.U.) whereas the adsorbed toxoids had approximately 200 I.U. The international unitage of these toxoids reflected the persistence of the human protective antitoxin level but not the early primary response. The assay results were in agreement with findings of other workers that the mouse as well as the guinea pig may be satisfactory for potency assay of adsorbed toxoids. The need for determination of the international unitage of tetanus toxoids used in human studies and the confirmation of the relationship of this value to persistence of antitoxin levels is emphasized.
KW  - Tetanus toxoids--potency-;
KW  - Tetanus toxoids--immunization-;
KW  - Immunization--tetanus--neonatal, laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response;
KW  - Dosage forms--tetanus toxoids--adsorbed, and plain, potency;
KW  - Standards--tetanus toxoids--need to correlate assay values with human antitoxin response;
KW  - Drugs--clinical effectiveness--tetanus toxoids;
KW  - Equivalency--tetanus toxoids--adsorbed and plain dosage forms;
KW  - Dosage--tetanus toxoids--need for standards;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schrecker, A. W.;
T1  - Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts
CT  - Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/03/01/
VL  - 30
IS  - Mar
SP  - 632
EP  - 641
SN  - 00085472
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3903; Language: English; Trade Name: Cytosine; Generic Name: Cytarabine; Chemical Name: Cytarabine--147-94-4; References: 44; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - The phosphorylation of cytarabine and other nucleosides and nucleotides was studied in cell-free extracts of leukemia L1210 and in a subline resistant to the drug.
KW  - Cytarabine--and other nucleosides and nucleotides-;
KW  - Metabolism--cytarabine--and other nucleosides and nucleotides, phosphorylation, in cell-free extracts of leukemia L1210 and in resistant subline;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, B. G.;
AU  - Swart, B. E.;
T1  - Evidence for the presence of anti-Burkitt tumor globulins in pooled human immune globulins
CT  - Evidence for the presence of anti-Burkitt tumor globulins in pooled human immune globulins
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/03/01/
VL  - 30
IS  - Mar
SP  - 763
EP  - 767
SN  - 00085472
AD  - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3902; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents globulins; References: 15; Journal Coden: CNREA8; Section Heading: Pharmacology; Abstract Author: Jimmie L. Hall
N2  - Twenty lots of commercially pooled human globulins were found to suppress the growth of EB3 and other cells derived from Burkitt's lymphoma and human leukemias. This observation suggests that passive immunity to these conditions might be obtained with #OQ#OQnormal'' immune human globulin.
KW  - Globulins--immune--pooled human, evidence for presence of anti-Burkitt tumor globulins;
KW  - Antineoplastic agents--globulins--immune, pooled human, evidence for presence of anti-Burkitt tumor globulins;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levine, P. H.;
AU  - Regelson, W.;
AU  - Holland, J. F.;
T1  - Chloramphenicol-associated encephalopathy
CT  - Chloramphenicol-associated encephalopathy
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1970/03/01/
VL  - 11
IS  - Mar-Apr
SP  - 194
EP  - 199
SN  - 00099236
AD  - Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3131; Language: English; Chemical Name: Chloramphenicol--56-75-7; References: 36; Journal Coden: CLPTAT; Section Heading: Adverse Drug Reactions; Abstract Author: Monte S. Cohon
N2  - Oral chloramphenicol as a causative agent of toxic delirium in 3 patients is discussed. Cessation of therapy resulted in disappearance of the symptoms. When the drug was resumed, symptoms reappeared. The same dosage of chloramphenicol parenterally did not result in encephalopathy.
KW  - Chloramphenicol--adverse reactions-;
KW  - Drugs, adverse reactions--chloramphenicol--oral, associated encephalopathy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kalser, S.;
AU  - McLain, P. L.;
T1  - Atropine metabolism in man
CT  - Atropine metabolism in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1970/03/01/
VL  - 11
IS  - Mar-Apr
SP  - 214
EP  - 227
SN  - 00099236
AD  - National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
N1  - Accession Number: 7-3295; Language: English; Chemical Name: Atropine--51-55-8; References: 17; Journal Coden: CLPTAT; Section Heading: Drug Metabolism and Body Distribution
N2  - Administration of two 14C-tropine-labeled atropines to man shows the urinary excretion of 77 to 93% of the injected dose in 24 hours. Only the N-methyl-14C but not the 2,4-14C-atropine shows oxidation to 14CO2 with a respiratory elimination of 3% in 3 hours. Atropine disappears very rapidly from the blood. Urinary excretion over the first 24 hours occurs at 2 rates; a fast rate occurring first with a t1/2 of about 2 hours and a slow rate with a t1/2 of about 13 to 38 hours. The early urine samples show the major fraction of the 14C existing as a chromatographic component which is a beta-glucuronide. The urines collected at later periods (4 to 8 hours) contain little, if any, of this component. The chromatographically distinguishable 14C-containing urinary components do not differ between the two 14C-atropines.
KW  - Atropine--14C-tropine-labeled-;
KW  - Metabolism--atropine--14C-tropine-labeled, derivatives;
KW  - Excretion--atropine--14C-tropine-labeled, derivatives;
KW  - Blood levels--atropine--14C-tropine-labeled, derivatives;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Slagle, James R.
AU  - Dixon, John K.
T1  - Experiments with the M & N Tree-Searching Program
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1970/03//
VL  - 13
IS  - 3
M3  - Article
SP  - 147
PB  - Association for Computing Machinery
SN  - 00010782
AB  - The m & n procedure is an improvement to the mini-max backing-up procedure widely used in computer programs for game-playing and other purposes. It is based on the principle that it is desirable to have many options when making decisions in the face of uncertainty. The mini-max procedure assigns to a max (min) node the value of the highest (lowest) valued successor to that node. The m & n procedure assigns to a max (min) node some function of the m (n) highest (lowest) valued successors. An m & n procedure was written in lisp to play the game of kalah, and it was demonstrated that the m & n procedure is significantly superior to the mini-max procedure. The statistical significance of important conclusions is given. Since information on statistical significance has often been lacking in papers on computer experiments in the artifical intelligence field, these experiments can perhaps serve as a model for future work.
KW  - COMPUTER programs
KW  - GAME theory
KW  - LISP (Computer program language)
N1  - Accession Number: 5355292; Slagle, James R.; Dixon, John K. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: Mar70, Vol. 13 Issue 3, p147; Note: Publisher: Association for Computing Machinery; Note: Update Code: 0500; Subject Term: COMPUTER programs; Subject Term: GAME theory; Subject Term: LISP (Computer program language); Number of Pages: 9p; Illustrations: 2 charts, 4 diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Robinson, John P.
T1  - PUBLIC REACTION TO POLITICAL PROTEST: CHICAGO 1968.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1970///Spring70
VL  - 34
IS  - 1
M3  - Article
SP  - 1
EP  - 9
PB  - Oxford University Press / USA
SN  - 0033362X
AB  - Despite press and television coverage largely sympathetic to antiwar demonstrators who clashed with Chicago police on August 28, 1968, public opinion remained overwhelmingly unsympthetic. Here, John P. Robinson examines two main questions: Who comprised the minority sympathetic to the demonstrators? How did attitudes toward the protesters and the police affect presidential voting behavior in November 1968, particularly among Democrats and Independents, whose voting behavior was most likely to be affected by the events in Chicago? [ABSTRACT FROM AUTHOR]
AB  - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Demonstrations (Collective behavior)
KW  - Public opinion
KW  - Crowds
KW  - Peace movements
KW  - Chicago (Ill.)
KW  - Illinois
N1  - Accession Number: 5415627; Robinson, John P. 1,2,3; Affiliations: 1: Study Director, Survey Research Center; 2: Assistant Professor, Department of Journalism, University of Michigan; 3: Research Coordinator, Surgeon General's Television and Social Behavior Program, National Institute of Mental Health; Issue Info: Spring70, Vol. 34 Issue 1, p1; Thesaurus Term: Demonstrations (Collective behavior); Thesaurus Term: Public opinion; Subject Term: Crowds; Subject Term: Peace movements; Subject: Chicago (Ill.); Subject: Illinois; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 84005688
T1  - Detection of growth-hormone deficiency.
AU  - Mitchell, M. L.
AU  - Byrne, M. J.
AU  - Sanchez, Y.
AU  - Sawin, C. T.
Y1  - 1970/03/05/
N1  - Accession Number: 84005688. Language: English. Entry Date: 20161118. Revision Date: 20170223. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Human Growth Hormone -- Blood
KW  - Hypopituitarism -- Diagnosis
KW  - Glucagon -- Administration and Dosage
KW  - Injections, Intramuscular
KW  - Hypopituitarism -- Blood
KW  - Pituitary Diseases -- Blood
KW  - Injections, Subcutaneous
KW  - Chemical and Pharmacologic Phenomena
KW  - Male
KW  - Female
KW  - Radioimmunoassay
KW  - Time Factors
SP  - 539
EP  - 541
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 282
IS  - 10
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Supported by a research grant (AM-12640) from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service, and by Part I Research Funds from the Veterans Administration Medical Research and Education Service, Veterans Administration Central Office, Washington, D.C.
U2  - PMID: 5413105.
DO  - 10.1056/NEJM197003052821005
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Oren, M. E.;
AU  - Herberman, R. B.;
AU  - Rogentine, G. N., Jr.;
T1  - Effect of heparin on the detection of human isoantigens by the cytotoxicity technique
CT  - Effect of heparin on the detection of human isoantigens by the cytotoxicity technique
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1970/03/07/
VL  - 225
IS  - Mar 7
SP  - 951
EP  - 952
AD  - Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-4142; Language: English; Chemical Name: Heparin--9005-49-6; References: 31; Journal Coden: NATUAS; Section Heading: Pharmacology; Abstract Author: Robert A. Hall
N2  - Heparin, by coating the cell surface or some other mechanism, may have a significant influence on immunological reaction involving mouse cells, but does not seem to have significant effects on human lymphocytes.
KW  - Heparin--effects-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mendell, J. R.;
AU  - Chase, T. N.;
AU  - Engel, W. K.;
T1  - Modification by L-dopa of a case of progressive supranuclear palsy
CT  - Modification by L-dopa of a case of progressive supranuclear palsy
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1970/03/21/
VL  - 1
IS  - Mar 21
SP  - 593
EP  - 594
SN  - 00237507
AD  - Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, and Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-2052; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 13; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Lamar Orr
N2  - A case of progressive supranuclear palsy is reported in which the biochemical findings were suggestive of a defect in cerebral dopamine metabolism, and whose neurological state improved on treatment with L-dopa (levodopa).
KW  - Levodopa--progressive supranuclear palsy-;
KW  - Antiparkinson agents--levodopa--modification of case of progressive supranuclear palsy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Curran, R. E.;
AU  - Johnson, R. E.;
T1  - Tolerance to chemotherapy after prior irradiation for Hodgkin's disease
CT  - Tolerance to chemotherapy after prior irradiation for Hodgkin's disease
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/04/01/
VL  - 72
IS  - Apr
SP  - 505
EP  - 509
SN  - 00034819
AD  - Radiation Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-2235; Language: English; References: 15; Journal Coden: AIMEAS; Section Heading: Toxicity
N2  - Although intensive radiotherapy is generally well tolerated by patients with Hodgkin's disease, such treatment significantly reduces the bone marrow reserve. The hematologic tolerance to chemotherapy was evaluated in patients who had received prior irradiation. The important factors in determining the postirradiation tolerance to chemotherapy were extent of bone marrow irradiated and the time interval from completion of radiotherapy to onset of chemotherapy. Inability to deliver adequate chemotherapy after extensive radiotherapy was associated with both failure to achieve drug-induced remissions and limited survival times. This experience serves to emphasize the necessity for a rigorous diagnostic evaluation for each patient before institution of radical radiotherapy. Failure to carefully investigate the extent of disease, especially with respect to extranodal involvement, can only result in a radiation-induced reduction of bone marrow reserve which may prevent the subsequent administration of effective (though palliative) chemotherapy.
KW  - Irradiation--Hodgkin's disease--therapy, tolerance to subsequent chemotherapy;
KW  - Drugs--Hodgkin's disease--therapy, tolerance to chemotherapy after prior irradiation;
KW  - Antineoplastic agents--Hodgkin's disease--therapy, tolerance to chemotherapy after prior irradiation;
KW  - Toxicity studies--tolerance to chemotherapy after prior irradiation for Hodgkin's disease;
KW  - Drug interactions--irradiation--tolerance to subsequent chemotherapy, for Hodgkin's disease;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Epstein, S. E.;
AU  - Skelton, C. L.;
AU  - Levey, G. S.;
AU  - Entman, M.;
T1  - Adenyl cyclase and myocardial contractility
CT  - Adenyl cyclase and myocardial contractility
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/04/01/
VL  - 72
IS  - Apr
SP  - 561
EP  - 578
SN  - 00034819
AD  - National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-3629; Language: English; References: 76; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2  - The activity of many hormones can be related to their capacity to increase adenyl cyclase activity in their target organs. Evidence that the augmentation of myocardial contractility produced by catecholamines is mediated by adenyl cyclase activation is summarized. Glucagon and thyroid hormone also enhance myocardial adenyl cyclase activity, findings compatible with the hypothesis that activation of this enzyme may also be responsible for the increased contractility produced by glucagon and associated with hyperthyroidism. The inotropic action of epinephrine and glucagon may be due to an increase in sarcotubular calcium stores, an effect that appears to be related to activation of an adenyl cyclase in the microsomal fraction. Chronic cardiac decompensation did not alter the capacity of norepinephrine to enhance contractility or activate adenyl cyclase, but it markedly impaired the capacity of glucagon to elicit these responses. Thus, glucagon may have limited value in the treatment of patients with chronic heart failure.
KW  - Hormones--effects--related to adenyl cyclase activity in target organs;
KW  - Mechanism of action--hormones--effects, related to adenyl cyclase activity in target organs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Brown, C. H., III;
AU  - Stashick, E.;
AU  - Carbone, P. P.;
T1  - Clinical efficacy and lack of toxicity of allopurinol (NSC-1390) given intravenously
CT  - Clinical efficacy and lack of toxicity of allopurinol (NSC-1390) given intravenously
JO  - Cancer Chemother. Rept.
JF  - Cancer Chemother. Rept.
Y1  - 1970/04/01/
VL  - 54
IS  - Apr
SP  - 125
EP  - 129
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-4084; Language: English; Trade Name: NSC-1390; Generic Name: Allopurinol; Chemical Name: Allopurinol--315-30-0; References: 4; Journal Coden: CNCRA6; Section Heading: Drug Evaluations; Abstract Author: Paul J. Miller
N2  - Allopurinol given intravenously in very high doses to 16 patients produced no apparent clinical toxicity. The patients received allopurinol as prophylaxis against and treatment for hyperuricemia. Dosages ranged from 105 mg./m.2/24 hours for 4 days to 660 mg./m.2/24 hours for 11 days. The results of the study showed definite therapeutic activity, but no serious drug toxic effects.
KW  - Allopurinol--hyperuricemia-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Haskell, C. M.;
AU  - Canellos, G. P.;
T1  - Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists
CT  - Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/04/01/
VL  - 30
IS  - Apr
SP  - 1081
EP  - 1083
SN  - 00085472
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 8-3824; Language: English; Chemical Name: Asparagine--7006-34-0 Glutamine--6899-04-3 Norleucine--327-57-1; References: 18; Journal Coden: CNREA8; Section Heading: Drug Interactions; Pharmacology; Abstract Author: Jimmie L. Hall
N2  - In this experiment, the effect of various asparagine or glutamine antagonists on asparagine synthetase levels in vitro was studied. Theoretically, the antineoplastic effect of asparaginase could be enhanced by the concurrent administration of an agent which inhibits asparagine synthetase, thus inhibiting the synthesis of L-asparagine from L-aspartic acid. In this experiment, the effect of various compounds on asparagine synthetase levels was determined in human tumor cells in vitro. The asparagine analogs, DL-aspartic acid-\b/-hydroxamic acid (DL-BAH), and 5-diazo-4-oxo-L-norvaline (DONV), as well as L-asparagine itself reduced enzyme levels. Presumably, however, these compounds would be destroyed by L-asparaginase if given concurrently with it. Moreover, DONV binds irreversably with asparaginase and renders it inactive. Of the glutamine analogs, 6-diazo-5-oxo-L-norleucine (DON) and azotomycin markedly reduced enzyme levels, while duazomycin A and azaserine did so only slightly. Asparagine synthetase levels were neither increased nor decreased by puromycin. The implications of combining these drugs with asparaginase are discussed.
KW  - Asparagine--antagonists-;
KW  - Glutamine--antagonists-;
KW  - Norleucine--6-diazo-5-oxo-L--;
KW  - Azotomycin--effects-;
KW  - Enzyme inhibitors--asparagine--antagonists, effects on asparagine synthetase levels, in human tumor cells, in vitro;
KW  - Enzyme antagonists--glutamine--antagonists, effects on asparagine synthetase levels, in human tumor cells, in vitro;
KW  - Drug interactions--asparaginase--and other drugs, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Levine, S.
AU  - Hoenig, E. M.
AU  - Kies, Marian W.
T1  - ALLERGIC ENCEPHALOMYELITIS: IMMUNOLOGICALLY SPECIFIC INHIBITION OF CELLULAR PASSIVE TRANSFER BY ENCEPHALITOGENIC BASIC PROTEINS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1970/04//
VL  - 6
IS  - 4
M3  - Article
SP  - 503
EP  - 517
SN  - 00099104
AB  - Passive transfer of experimental allergic encephalomyelitis (EAE) was performed with lymph node cells from donor rats immunized with spinal cord or purified encephalitogenic basic protein and any of several adjuvant combinations. Transfer was inhibited by injection of recipients with the brain basic protein. Basic proteins from rat and guinea-pig CNS inhibited transfer from donors immunized with rat or guinea-pig spinal cord or basic protein. Monkey basic protein inhibited transfer from donors immunized with monkey or human cord. There was only partial cross-inhibition between rodent and primate groups. The inhibition was organ specific in that basic proteins from lung, spleen and adrenal did not inhibit transfer of EAE. Furthermore, transfer of adrenalitis from donors immunized with adrenal tissue was inhibited by adrenal extracts but not by CNS basic protein. Pertussis and typhoid vaccines injected into recipients inhibited transfer of either EAE or adrenalitis. This non-specific inhibition was also demonstrated after simultaneous transfer of both EAE and adrenalitis, whereas CNS basic protein eliminated only EAE in such recipients. Inhibition was complete in experiments terminated one day after transfer. In  longer experiments, inhibition lasted only 3 or 4 days. Basic protein was rapidly cleared from the blood. Neither spleen nor adrenals were necessary for its action. Brain basic protein prevented the interaction between encephalitogenic cells and the target Organ by an immunologically specific mechanism which may be a type of desensitization. The inhibition could not be reproduced in vitro. Bioassay and radioactive tracers revealed that basic protein bound non-specifically to living or dead lymph node cells in vitro. The effects of incubation could be accounted for by this non-specific carry-over of basic protein into the recipients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENCEPHALOMYELITIS
KW  - LYMPH
KW  - DEMYELINATION
KW  - PROTEINS
KW  - CENTRAL nervous system -- Diseases
KW  - LYMPHOID tissue
N1  - Accession Number: 14587029; Levine, S. 1,2; Hoenig, E. M. 1,2; Kies, Marian W. 1,2; Source Information: Apr70, Vol. 6 Issue 4, p503; Subject: ENCEPHALOMYELITIS; Subject: LYMPH; Subject: DEMYELINATION; Subject: PROTEINS; Subject: CENTRAL nervous system -- Diseases; Subject: LYMPHOID tissue; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - 
AU  - Read, Merrill S.1
T1  - Malnutrition and Learning.
JO  - Education Digest
JF  - Education Digest
J1  - Education Digest
PY  - 1970/04//
Y1  - 1970/04//
VL  - 35
IS  - 8
CP  - 8
M3  - Article
SP  - 8
EP  - 11
SN  - 0013127X
AB  - The article discusses various issues related to malnutrition and learning in the U.S. Malnutrition is a state in which an individual lacks one or more nutrients to the extent that specific symptoms and conditions appear, or retardation in physical development occurs. It is informed that the National Nutrition Survey, begun in 1968 and being carried out by the U.S. Department of Health, Education, and Welfare. It was the first comprehensive effort to assess the nutritional status of the U.S. population. Preliminary results have been reported on the study of 12,000 people of all ages, randomly selected in poverty pockets in two states and several smaller areas. The survey found an unexpectedly high prevalence of symptoms associated with malnutrition. In an eight-year study of Mexican children, investigators found that intellectual performance at the time of entry into school appeared to be related to the child's history of malnutrition. After the children spent four to five years in school, however, this relationship disappeared, and differences in performance appeared more closely related to socioeconomic conditions and regularity of school attendance.
KW  - Malnutrition
KW  - Education -- United States
KW  - Intellect
KW  - School attendance
KW  - Nutrition disorders
KW  - United States
N1  - Accession Number: 18844736; Authors: Read, Merrill S. 1; Affiliations:  1: Program Director, Growth and Development Branch, National Institute of Child Health and Human Development, Bethesda, Maryland.; Subject: Malnutrition; Subject: Education -- United States; Subject: Intellect; Subject: School attendance; Subject: Nutrition disorders; Subject: United States; Number of Pages: 4p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
AU  - Colten, H.R.
AU  - Borsos, T.
AU  - Rapp, H.J.
T1  - Isoelectric Focusing of Human and Guinea-Pig C2: Polymorphism of Guinea-Pig C2.
JO  - Immunology
JF  - Immunology
Y1  - 1970/04//
VL  - 18
IS  - 4
M3  - Article
SP  - 467
EP  - 472
SN  - 00192805
AB  - The isoelectric point (pI) of human and guinea-pig C2 was determined by electrofocusing. The results showed that human C2 and C2 of some guinea-pigs had a pi of approximately pH 5-5-5·6; in some guinea-pig sera C2 activity was resolved into two fractions, one with a pi of about 5·2 and the other of about 5·5. The data suggest the possibility that guinea-pig C2 may exist in at least two allotypic forms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPLEMENT (Immunology)
KW  - BLOOD proteins
KW  - ISOELECTRIC focusing
KW  - GUINEA pigs
KW  - IMMUNOLOGY
KW  - SEPARATION (Technology)
N1  - Accession Number: 13358591; Colten, H.R. 1; Borsos, T. 1; Rapp, H.J. 1; Source Information: Apr70, Vol. 18 Issue 4, p467; Subject: COMPLEMENT (Immunology); Subject: BLOOD proteins; Subject: ISOELECTRIC focusing; Subject: GUINEA pigs; Subject: IMMUNOLOGY; Subject: SEPARATION (Technology); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Sallmann, L.;
AU  - Grimes, P.;
T1  - Cataractogenic effect of dibromomannitol in rats
CT  - Cataractogenic effect of dibromomannitol in rats
JO  - Invest. Ophthalmol.
JF  - Invest. Ophthalmol.
Y1  - 1970/04/01/
VL  - 9
IS  - Apr
SP  - 291
EP  - 299
AD  - National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-2679; Language: English; References: 13; Journal Coden: INOPAO; Section Heading: Toxicity; Abstract Author: James W. Dungee
N2  - Presented is a study of the effect of dibromomannitol (DBM) on the corneas of a group of rats. A single dose (1 g./kg.) of DBM, administered to a group of rats resulted in no cataracts during a one-month examination period. A chronic dose of 90 mg. per kg. daily, administered over a number of days to another group of rats, resulted in no cataracts after one month, but mild epithelial damage. A chronic dose of 180 mg. per kg. daily fed to another group of rats resulted in cataracts in the majority of the group, after 4 weeks.
KW  - Dibromomannitol--cataractogenic effect-;
KW  - Toxicity studies--dibromomannitol--cataractogenic effect, in rats;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lowenbraun, S.;
AU  - Young, V.;
AU  - Kenton, D.;
AU  - Serpick, A. A.;
T1  - Infection from intravenous #OQ#OQscalp-vein'' needles in a susceptible population
CT  - Infection from intravenous #OQ#OQscalp-vein'' needles in a susceptible population
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1970/04/20/
VL  - 212
IS  - Apr 20
SP  - 451
EP  - 453
AD  - Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1  - Accession Number: 8-0938; Language: English; References: 8; Journal Coden: JAMAAP; Section Heading: Environmental Toxicity
N2  - Intravenous indwelling scalp-vein needles were cultured in a population with neoplastic disease. Twenty-four of the 74 needles cultured were positive; microorganisms generally considered pathogenic grew from 7 of these needles. The latter organisms included \IT/Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans\OK/, \a/-hemolytic Streptococcus, and group D Streptococcus. Infected scalp-vein needles were the bacteriologic source in one case of septicemia and one case of cellulitis. There was a trend toward increasing incidence of growth with increasing duration of needle placement.
KW  - Needles--scalp-vein--intravenous indwelling, pathogenic contamination;
KW  - Contamination--needles--scalp-vein, intravenous indwelling, by pathogenic microorganisms;
KW  - Toxicity--needles--scalp-vein, intravenous indwelling, pathogenic contamination;
KW  - Toxicity, environmental--needles--scalp-vein, intravenous indwelling, pathogenic contamination;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lowenbraun, Stanley
AU  - Ramsey, Harold
AU  - Sutherland, John
AU  - Serpick, Arthur A.
T1  - Diagnostic Laparotomy and Splenectomy for Staging Hodgkin's Disease.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1970/05//
VL  - 72
IS  - 5
M3  - Article
SP  - 655
EP  - 663
SN  - 00034819
AB  - Diagnostic laparotomies and splenectomies were performed on 12 patients to determine more accurately the extent of Hodgkin's disease in the abdomen. Preoperatively, the patients were carefully staged as recommended by the Rye Conference in 1966. At laparotomy four out of nine positive lymphograms were uncorroborated by surgical findings and biopsies, as was one positive inferior vena cavogram. Splenic disease was found in four out of six patients whose preoperative evaluations were negative in this regard. Hodgkin's infiltration of porta hepatic, splenic hilar, and mesenteric lymph nodes was found in three, two, and one patient, respectively. In one patient a retroperitoneal mass was discovered that extended 4 cm laterally to nodes visualized by lymphography and outside usual fields for radiotherapy. None of the hepatic wedge biopsies were positive. Three patients had their stages changed on the basis of laparotomy findings, and an additional seven patients had changes in their known extent of lymphomatous involvement. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ABDOMINAL surgery
KW  - SPLENECTOMY
KW  - HODGKIN'S disease
KW  - EXCISION (Surgery)
KW  - SPLEEN -- Surgery
KW  - LYMPHOMAS
N1  - Accession Number: 12556452; Lowenbraun, Stanley 1; Ramsey, Harold 1; Sutherland, John 1; Serpick, Arthur A. 1; Source Information: May70, Vol. 72 Issue 5, p655; Subject: ABDOMINAL surgery; Subject: SPLENECTOMY; Subject: HODGKIN'S disease; Subject: EXCISION (Surgery); Subject: SPLEEN -- Surgery; Subject: LYMPHOMAS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Letz, F. H.;
AU  - Stefano, F. J. E.;
T1  - Desipramine-induced release of norepinephrine from heart
CT  - Desipramine-induced release of norepinephrine from heart
JO  - Biochem. Pharmacol.
JF  - Biochem. Pharmacol.
Y1  - 1970/05/01/
VL  - 19
IS  - May
SP  - 1797
EP  - 1801
AD  - Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-0045; Language: English; Chemical Name: Desipramine--50-47-5; References: 21; Journal Coden: BCPCA6; Section Heading: Pharmacology
N2  - Desipramine (DMI) in low concentrations inhibits the uptake of norepinephrine (NE) by sympathetic nerve endings but does not release the amine. In high concentrations, however, DMI releases NE. The rate of NE release from heart slices depends on the DMI concentration; at 25 mcg./ml., the NE stores are depleted by 50% in 4 hours; at 50 mcg./ml., they are depleted by 50% in one hour. In the isolated heart, DMI releases the NE mainly in the form of deaminated metabolites, indicating that the drug acts within the neuron, possibly on the storage granules.
KW  - Desipramine--induced release of norepinephrine-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - German, L. G.;
T1  - Microbiology of the intimate environment
CT  - Microbiology of the intimate environment
JO  - Bull. Parenteral Drug Assoc.
JF  - Bull. Parenteral Drug Assoc.
Y1  - 1970/05/01/
VL  - 24
IS  - May-Jun
SP  - 105
EP  - 109
AD  - Environmental Services Branch, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-2432; Language: English; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2  - The role of bacteria, yeasts, molds, and viruses in, on, and around a drug production area can be both fascinating and hazardous. Although antibiotics and chemicals may be used to control microbial growth, not all patients can tolerate them. Physical equipment and methods that can maintain safe microbial levels are discussed.
KW  - Control--microbiological--equipment and methods for maintaining safe microbial levels;
KW  - Microorganisms--control--equipment and methods for maintaining safe microbial levels;
KW  - Equipment--and methods for maintaining safe microbial levels;
KW  - Contamination--microbiological--equipment and methods for maintaining safe microbial levels;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Sandberg, J. S.;
AU  - Goldin, A.;
T1  - Use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate
CT  - Use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/05/01/
VL  - 30
IS  - May
SP  - 1276
EP  - 1280
SN  - 00085472
AD  - Cancer Chemotherapy National Service Center, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 7-4544; Language: English; Trade Name: Citrovorum factor; Generic Name: Leucovorin; Chemical Name: Leucovorin--58-05-9 Methotrexate--59-05-2; References: 24; Journal Coden: CNREA8; Section Heading: Drug Interactions; Abstract Author: Jimmie L. Hall
N2  - Citrovorum factor (leucovorin) is used parenterally to reduce the toxicity of methotrexate. This study demonstrates that, in mice, this protective effect is retained when the drug is given orally.
KW  - Leucovorin--oral-;
KW  - Methotrexate--toxicity-;
KW  - Dosage forms--leucovorin--oral, use in normal and leukemic mice to prevent toxicity and GI lesions caused by high doses of methotrexate;
KW  - Toxicity--methotrexate--caused by high doses in normal and leukemic mice, protective effect of oral leucovorin;
KW  - Drug interactions--methotrexate--use of oral leucovorin to prevent the toxicity and GI lesions caused by high doses, in normal and leukemic mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Oliverio, V. T.;
AU  - Vietzke, W. M.;
AU  - Williams, M. K.;
AU  - Adamson, R. H.;
T1  - Absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals
CT  - Absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/05/01/
VL  - 30
IS  - May
SP  - 1330
EP  - 1337
SN  - 00085472
AD  - Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-0268; Language: English; Chemical Name: Urea--57-13-6; References: 21; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Investigational Drugs
N2  - This article reports studies of the disposition of labeled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in mice, rats, dogs, and monkeys. Determinations were made with the \SU/14\BS/C label in each of 3 positions of the molecule, the ethylene, carbonyl, and cyclohexyl moieties. CCNU is lipid soluble, and after parenteral dosage, rapidly degraded in mouse and dog plasma with 2 exponential phases. The half-life of the initial phase is about 5 minutes, while the second phase extends over one hour. During the 6 hours after I.V. injection of ethylene-labeled CCNU in dogs, radioactivity in the cerebrospinal fluid exceeded that of plasma 3-fold. Wth the label in the cyclohexyl moiety, plasma radioactivity was about 50% of cerebrospinal fluid levels. Following biotransformation, the drug is excreted primarily by the kidneys, with excretion being essentially complete during the first 24 hours in rodents and monkeys, but more protracted in dogs. Biliary secretion and reabsorption from the gastrointestinal tract have been demonstrated. The cyclohexyl portion of the molecule was bound extensively to plasma proteins of dogs, while the ethylene moiety was not.
KW  - Urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso--;
KW  - Absorption--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
KW  - Drugs, body distribution--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
KW  - Excretion--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
KW  - Metabolism--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Colvin, M.;
AU  - Bono, V. H., Jr.;
T1  - Enzymatic reduction of hydroxyurea to urea by mouse liver
CT  - Enzymatic reduction of hydroxyurea to urea by mouse liver
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/05/01/
VL  - 30
IS  - May
SP  - 1516
EP  - 1519
SN  - 00085472
AD  - Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-0267; Language: English; Chemical Name: Hydroxyurea--127-07-1; References: 20; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Jimmie L. Hall
N2  - This study reports that hydroxyurea is enzymatically reduced to urea by mouse liver tissue and that this reaction occurs to a large extent in the hepatic mitochondria.
KW  - Hydroxyurea--metabolism-;
KW  - Metabolism--hydroxyurea--enzymatic reduction to urea, by mouse liver;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jasinski, D. R.;
AU  - Martin, W. R.;
AU  - Hoeldtke, R. D.;
T1  - Effects of short and long-term administration of pentazocine in man
CT  - Effects of short and long-term administration of pentazocine in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1970/05/01/
VL  - 11
IS  - May-Jun
SP  - 385
EP  - 403
SN  - 00099236
AD  - National Institute of Mental Health, Addiction Research Center, United States Department of Health, Education and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1  - Accession Number: 7-3219; Language: English; Chemical Name: Pentazocine--359-83-1; References: 31; Journal Coden: CLPTAT; Section Heading: Pharmacology
N2  - Pentazocine produces morphine-like subjective effects. A dose of 60 mg. per 70 kg. produces subjective effects which more closely resemble those of nalorphine than those of morphine. Pentazocine will not suppress abstinence symptoms in subjects dependent on either 60 or 240 mg. per day of morphine. Pentazocine is 1/50 as potent as nalorphine in precipitating abstinence symptoms in subjects dependent on 240 mg. of morphine per day. Long-term administration of pentazocine produces dependence which has elements of both morphine and nalorphine dependence. It is concluded that pentazocine has an abuse potential which is less than that with morphine but greater than that with nalorphine.
KW  - Pentazocine--effects-;
KW  - Dependence--pentazocine;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
T1  - SLEEP CYCLES AND SKIN POTENTIAL IN NEWBORNS STUDIED WITH A SIMPLIFIED OBSERVATION AND RECORDING SYSTEM.
AU  - Bell, Richard Q.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1970/05//
VL  - 6
IS  - 6
SP  - 778
EP  - 786
SN  - 00485772
N1  - Accession Number: 11049746; Author: Bell, Richard Q.: 1 ; Author Affiliation: 1 National Institute of Mental Health.; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20031223
N2  - A simple visual observation system, supplemented by measurement of skin potential, was devised for developmental studies of sleep cycles in settings where multiple electrode placement is not practicable. The findings replicated essential features of quiet and active sleep cycles which had been reported previously to exist against the background of decreasing level of physiological arousal, as sleep proceeds. Twelve newborns showed approximately one-half of their interfeeding sleeping time in the rapid eye movement stage of sleep. Skin potential rapidly declined from the waking level, continued to decrease in level throughout sleep, increased in variability during REM sleep, and increased in level at the second waking period. ABSTRACT FROM AUTHOR
KW  - *GALVANIC skin response
KW  - *REFLEXES
KW  - *SLEEP
KW  - *ELECTROPHYSIOLOGY
KW  - NEWBORN infants
KW  - Newborns.
KW  - Skin potential
KW  - Sleep
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
TY  - GEN
AU  - Courtney, K. D.;
AU  - Gaylor, D. W.;
AU  - Hogan, M. D.;
AU  - Falk, H. L.;
AU  - Bates, R. R.;
AU  - \ET/;
T1  - Teratogenic evaluation of 2,4,5-T
CT  - Teratogenic evaluation of 2,4,5-T
JO  - Science
JF  - Science
Y1  - 1970/05/15/
VL  - 168
IS  - May 15
SP  - 864
EP  - 866
AD  - National Institute of Environmental Health Sciences, National Institutes of Health, P. O. Box 12233, Research Triangle Park, North Carolina 27709
N1  - Accession Number: 8-0132; Language: English; References: 6; Journal Coden: SCIEAS; Section Heading: Toxicity
N2  - The herbicide 2,4,5-trichlorophenoxyacetic acid is teratogenic and fetocidal in 2 strains of mice when administered either subcutaneously or orally and in one strain of rats when administered orally.
KW  - Trichlorophenoxyacetic acid--2,4,5--;
KW  - Teratogenicity--trichlorophenoxyacetic acid--2,4,5-, in rodents;
KW  - Toxicity--trichlorophenoxyacetic acid--2,4,5-, teratogenic and fetocidal effects, in rodents;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - Kannel, William B.
AU  - Gordon, Tavia
AU  - Castelli, William P.
AU  - Margolis, James R.
T1  - Electrocardiographic Left Ventricular Hypertrophy and Risk of Coronary Heart Disease.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1970/06//
VL  - 72
IS  - 6
M3  - Article
SP  - 813
EP  - 822
SN  - 00034819
AB  - Risk of clinically overt coronary heart disease in 190 persons with "definite" and 264 with "possible" electrocardiographic left ventricular hypertrophy (ECG-LVH) was compared with that of a total cohort of 5,127 men and women followed over 14 years. Prevalence of both coronary heart disease and ECG-LVH increased in proportion to antecedent blood pressure. Persons who acquired "definite'' ECG-LVH had a residual threefold increased risk of clinically overt coronary heart disease after adjustment for the effect of coexisting hypertension. "Possible" ECG-LVH was associated with a twofold increased risk, but this was virtually obliterated on adjustment for hypertension. Risk of every clinical manifestation of coronary heart disease, and of death in particular, was increased, and 40% with prior ECG-LVH died in their initial attack, a fatality rate comparable with that of persons with prior overt coronary heart disease. ECG-LVH is thus a grave prognostic sign and a harbinger of clinically overt coronary heart disease, it is tempting to hypothesize that ECG-LVH without other explanation based mainly on increased voltage (possible LVH)is largely an expression of hypertensive hypertrophy and that with more marked voltage increases accompanied by S-T and T wave abnormality (definite LVH) indicates ischemic myocardial involvement. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ELECTROCARDIOGRAPHY
KW  - HYPERTROPHY
KW  - CORONARY heart disease
KW  - LEFT heart ventricle
KW  - ELECTRODIAGNOSIS
KW  - PATHOLOGY
N1  - Accession Number: 12584323; Kannel, William B. 1; Gordon, Tavia 1; Castelli, William P. 1; Margolis, James R. 1; Source Information: Jun70, Vol. 72 Issue 6, p813; Subject: ELECTROCARDIOGRAPHY; Subject: HYPERTROPHY; Subject: CORONARY heart disease; Subject: LEFT heart ventricle; Subject: ELECTRODIAGNOSIS; Subject: PATHOLOGY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Satterlee, Winston G.
AU  - Serpick, Arthur
AU  - Bianchine, Joseph R.
T1  - The Carcinoid Syndrome: Chronic Treatment with Para-Chlorophenylalanine.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1970/06//
VL  - 72
IS  - 6
M3  - Article
SP  - 919
EP  - 921
SN  - 00034819
AB  - Para-chlorophenylalanine is a potent depleter of tissue serotonin (5-hydroxytryptamine). Since 5-hydroxytryptamine may contribute to the pathogenesis of several aspects of the carcinoid syndrome, for 1 year we treated a patient with this syndrome with para-chlorophenylalanine. A 59-year-old man developed chronic diarrhea, hepatomegaly, right-sided valvular heart lesion, and cutaneous flush. Exploratory abdominal examination showed ileal carcinoid tumor metastatic to liver and nodes. Urine 5-hydroxyindoleacetic acid and serum 5-hydroxytryptamine levels were abnormally high. Para-chlorophenylalanine treatment promptly reduced both levels to normal and halted the diarrhea. Chronic treatment with para-chlorophenylalanine controlled the production of 5-hydroxytryptamine and diarrhea but did not prevent tumor growth, flushing; or progression of cardiac lesions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARCINOID
KW  - PHENYLALANINE
KW  - SEROTONIN
KW  - CHROMAFFIN cells -- Tumors
KW  - NEUROENDOCRINE tumors
KW  - AMINO acids
N1  - Accession Number: 12584380; Satterlee, Winston G. 1; Serpick, Arthur 1; Bianchine, Joseph R. 1; Source Information: Jun70, Vol. 72 Issue 6, p919; Subject: CARCINOID; Subject: PHENYLALANINE; Subject: SEROTONIN; Subject: CHROMAFFIN cells -- Tumors; Subject: NEUROENDOCRINE tumors; Subject: AMINO acids; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Vogel, C. L.;
AU  - Denham, C.;
AU  - Waalkes, T. P.;
AU  - DeVita, V. T.;
T1  - Physiological disposition of the carcinostatic imidazole-4(or5)-carboxamide, 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno](NSC-82196) (imidazole mustard) in mice and dogs
CT  - Physiological disposition of the carcinostatic imidazole-4(or5)-carboxamide, 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno](NSC-82196) (imidazole mustard) in mice and dogs
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/06/01/
VL  - 30
IS  - Jun
SP  - 1651
EP  - 1657
SN  - 00085472
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-1132; Language: English; Trade Name: NSC-82196; Generic Name: Imidazole; Chemical Name: Imidazole--288-32-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents imidazole; References: 15; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Preliminary Drug Testing; Abstract Author: Jimmie L. Hall
N2  - The physiological disposition, absorption, excretion, and metabolism of the title compound were studied in mice and dogs.
KW  - Imidazole--mustard-;
KW  - Absorption--imidazole--mustard, in mice and dogs;
KW  - Excretion--imidazole--mustard, in mice and dogs;
KW  - Metabolism--imidazole--mustard, in mice and dogs;
KW  - Antineoplastic agents--imidazole--mustard, physiological disposition, in mice and dogs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeWys, W. D.;
AU  - Goldin, A.;
AU  - Mantel, N.;
T1  - Hematopoietic recovery after large doses of cyclophosphamide: correlation of proliferative state with sensitivity
CT  - Hematopoietic recovery after large doses of cyclophosphamide: correlation of proliferative state with sensitivity
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/06/01/
VL  - 30
IS  - Jun
SP  - 1692
EP  - 1697
SN  - 00085472
AD  - Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-0984; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 31; Journal Coden: CNREA8; Section Heading: Toxicity; Abstract Author: Jimmie L. Hall
N2  - This study was designed to correlate the toxic effects of cyclophosphamide on stem cells with those on bone marrow and peripheral blood cells. The results are discussed in relation to treatment intervals with the drug.
KW  - Cyclophosphamide--hematopoietic recovery after large doses-;
KW  - Toxicity studies--cyclophosphamide--to correlate toxic effects on stem cells with those on bone marrow and peripheral blood cells;
KW  - Antineoplastic agents--cyclophosphamide--hematopoietic recovery after large doses, correlation of proliferative state with sensitivity;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - DeVita, V. T.;
T1  - Effect of chemotherapy on the growth characteristics and cellular kinetics of leukemia L1210
CT  - Effect of chemotherapy on the growth characteristics and cellular kinetics of leukemia L1210
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/06/01/
VL  - 30
IS  - Jun
SP  - 1789
EP  - 1794
SN  - 00085472
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-2984; Language: English; References: 16; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - The double-labeling technique with thymidine-\SU/3\BS/H and -\SU/14\BS/C was used to study the in vivo effects of chemotherapy on the cell cycle and proliferation characteristics of L1210 leukemia in the ascites form. A divergent effect of carmustine and cyclophosphamide on the S phase was noted; prolongation of the S phase occurred in cells following lethal injury with carmustine but not with cyclophosphamide.
KW  - Chemotherapy--effects--on growth characteristics and cellular kinetics of leukemia L1210;
KW  - Antineoplastic agents--effects--of chemotherapy, on growth characteristics and cellular kinetics of leukemia L1210;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Paul, W.E.
AU  - Siskind, G.W.
T1  - Hapten Specificity of Cellular Immune Responses as Compared with the Specificity of Serum Anti-hapten Antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1970/06//
VL  - 18
IS  - 6
M3  - Article
SP  - 921
EP  - 930
SN  - 00192805
AB  - Comparative specificity data have been presented for the interaction of anti-hapten antibody with a series of structurally related haptens and for the stimulation by hapten-guinea pig albumin (GPA) conjugates of DNA synthesis in lymph node cell cultures from guinea pigs immunized with a given conjugate. A good correlation in the specificity of serum anti-hapten antibody and in the specificity of stimulation of DNA synthesis has been demonstrated. Thus, mutual serologic and stimulatory cross-reactivity exist between the aminocaproates and GPA conjugates of the p-iodophenysulfonyl and toluenesulfonyl groups. Poor or undetectable serologic and stimulatory cross reactivity exist in the other combinations tested. The data is consistent with the notion that the interaction of antigen with an antibody-like cellular receptor is crucial to the elicitation of cellular immune responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAPTENS
KW  - IMMUNE response
KW  - CELLULAR immunity
KW  - ALBUMINS
KW  - ANTIGENS
KW  - IMMUNOLOGY
N1  - Accession Number: 13359421; Paul, W.E. 1; Siskind, G.W. 1; Source Information: Jun70, Vol. 18 Issue 6, p921; Subject: HAPTENS; Subject: IMMUNE response; Subject: CELLULAR immunity; Subject: ALBUMINS; Subject: ANTIGENS; Subject: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Mosimann, James E.
T1  - Size Allometry: Size and Shape Variables with Characterizations of the Lognormal and Generalized Gamma Distributions.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1970/06//
VL  - 65
IS  - 330
M3  - Article
SP  - 930
SN  - 01621459
AB  - Size-related shape changes in animals are studied within a general framework of size variables and shape vectors. Isometry, or independence of shape and size, is defined as the independence of some (all) shape vector(s) from a particular size variable. With mild restrictions it is shown that isometry is possible with respect to at most one size variable, or in other words that shape will always be related to a variety of size variables. The choice of a size variable is a hitherto neglected, but important, part of an allometric study.  The use of functional relationships in allometry is contrasted with the approach developed here. Also, size and shape variables are used in characterizations of the lognormal, gamma and generalized gamma distributions. The results, given in a biological context, are of interest in size and shape studies generally. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - MATHEMATICS
KW  - SAMPLING (Statistics)
KW  - STATISTICS
KW  - ALLOMETRY
KW  - SAMPLE size (Statistics)
KW  - LOGNORMAL distribution
KW  - VARIABLES (Mathematics)
N1  - Accession Number: 4606726; Mosimann, James E. 1; Affiliations: 1: Mathematical statistician with the National Institutes of Health.; Issue Info: Jun70, Vol. 65 Issue 330, p930; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MATHEMATICS; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: STATISTICS; Subject Term: ALLOMETRY; Subject Term: SAMPLE size (Statistics); Subject Term: LOGNORMAL distribution; Subject Term: VARIABLES (Mathematics); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Marshall, J. R.;
T1  - Ovulation induction
CT  - Ovulation induction
JO  - Obstetrics and Gynecology (USA)
JF  - Obstetrics and Gynecology (USA)
Y1  - 1970/06/01/
VL  - 35
IS  - Jun
SP  - 963
EP  - 970
SN  - 00297844
AD  - National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, Maryland
N1  - Accession Number: 7-3894; Language: English; Chemical Name: Clomiphene--911-45-5; References: 23; Journal Coden: OBGNAS; Section Heading: Pharmacology; Abstract Author: Judith A. Kepler
N2  - Indications for ovulation induction, evaluation of patients prior to therapy and methods of treatment with clomiphene citrate and gonadotropins are discussed.
KW  - Clomiphene--citrate-;
KW  - Gonadotropins--ovulation induction--evaluation;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lutterman, Kenneth G.
AU  - Middleton, Russell
T1  - AUTHORITARIANISM, ANOMIA, AND PREJUDICE.
JO  - Social Forces
JF  - Social Forces
Y1  - 1970/06//
VL  - 48
IS  - 4
M3  - Article
SP  - 485
EP  - 492
SN  - 00377732
AB  - Previous studies of the relationship of authoritarianism and anomia to prejudice have yielded inconsistent results. This study of 1,018 college and university students finds that authoritarianism is more highly correlated to prejudice than is anomia. Possible reasons for the varying results of the studies are examined. McDill's contention that there is a common general factor-a negative world view-underlying each of the scales is rejected on the basis of a factor analysis which reveals six distinct factors, none of which accounts for more than 13.5 percent of the total variance. It is concluded that the previous studies may have been compromised by acquiescence and other response biases and that there is little profit in attempting to determine the relative importance of authoritarianism and anomia as correlates of prejudice until better measures of the variables are developed which are relatively free of response bias. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTHORITARIANISM
KW  - ANOMIA
KW  - PREJUDICES
KW  - FACTOR analysis
KW  - ANALYSIS of variance
KW  - ATTITUDE (Psychology)
KW  - IDEOLOGY AND ISSUES
KW  - Psychological factors affecting tension
KW  - Racial and ethnic aspects of tension
N1  - Accession Number: 13530506; Lutterman, Kenneth G. 1; Middleton, Russell 2; Affiliations: 1 : National Institute of Mental Health.; 2 : University of Wisconsin.;  Source Info: Jun70, Vol. 48 Issue 4, p485; Subject Term: AUTHORITARIANISM; Subject Term: ANOMIA; Subject Term: PREJUDICES; Subject Term: FACTOR analysis; Subject Term: ANALYSIS of variance; Subject Term: ATTITUDE (Psychology); Author-Supplied Keyword: IDEOLOGY AND ISSUES; Author-Supplied Keyword: Psychological factors affecting tension; Author-Supplied Keyword: Racial and ethnic aspects of tension; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - 24h
ER  - 

TY  - JOUR
TY  - GEN
AU  - Griggs, R. C.;
AU  - Engel, W. K.;
AU  - Resnick, J. S.;
T1  - Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness
CT  - Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/07/01/
VL  - 73
IS  - Jul
SP  - 39
EP  - 48
SN  - 00034819
AD  - Medical Neurology Branch, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-3639; Language: English; Chemical Name: Acetazolamide--59-66-5; References: 30; Journal Coden: AIMEAS; Section Heading: Drug Evaluations
N2  - Although individual attacks of hypokalemic periodic paralysis are lessened by potassium treatment, recurrence is frequently not prevented by prophylactic potassium administration. Twelve patients with hypokalemic periodic paralysis were treated with acetazolamide in a placebo-controlled trial. Whereas the majority had failed to improve with previous therapy, 10 of the 12 patients were dramatically improved by acetazolamide. This response has been maintained for periods of 16 to 43 months with minimal or no side effects. Several patients previously disabled are now asymptomatic. In addition to eliminating attacks of weakness, acetazolamide also improved interattack weakness in 8 of 10 affected patients. The mechanism of effect of acetazolamide was not discovered. Acetazolamide produced a mild metabolic acidosis but did not have a demonstrable effect on total body sodium, total body potassium, or thyroid function. Acetazolamide is the most effective treatment available for hypokalemic periodic paralysis.
KW  - Acetazolamide--hypokalemic periodic paralysis-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pearson, J. W.;
AU  - Gibson, W. T.;
AU  - Chirigos, M. A.;
T1  - Use of a murine sarcoma virus in an in vivo assay for antiviral and antitumor agents
CT  - Use of a murine sarcoma virus in an in vivo assay for antiviral and antitumor agents
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/07/01/
VL  - 30
IS  - Jul
SP  - 2024
EP  - 2028
SN  - 00085472
AD  - Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-0715; Language: English; Chemical Name: Melphalan--148-82-3 Carmustine--154-93-8; Therapeutic Class: (8:18); AHFS Class: Virucides melphalan (8:18); AHFS Class: Virucides carmustine; References: 9; Journal Coden: CNREA8; Section Heading: Microbiology; Investigational Drugs
N2  - A variant of the murine sarcoma virus (Moloney) was used as a model for evaluating potential antiviral agents. Two drugs, melphalan, and carmustine, were tested for antiviral activity against a plasma variant of the murine sarcoma virus. The parameters utilized for drug effectiveness were retardation of splenomegaly and inhibition of virus synthesis in the drug-treated host animals. Both drugs were found to be effective.
KW  - Melphalan--activity-;
KW  - Carmustine--activity-;
KW  - Virucides--melphalan--activity, against plasma variant of murine sarcoma virus, in animals;
KW  - Virucides--carmustine--activity, against plasma variant of murine sarcoma virus, in animals;
KW  - Methodology--drug screening--variant of murine sarcoma virus used for evaluating potential antiviral agents;
KW  - Drugs--evaluations--variant of murine sarcoma virus used for evaluating potential antiviral agents;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Waalkes, T. P.;
AU  - Denham, C.;
AU  - DeVita, V. T.;
T1  - Pentamidine: clinical pharmacologic correlations in man and mice
CT  - Pentamidine: clinical pharmacologic correlations in man and mice
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1970/07/01/
VL  - 11
IS  - Jul-Aug
SP  - 505
EP  - 512
SN  - 00099236
AD  - The Human Tumor Cell Biology Branch and the Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-0803; Language: English; Chemical Name: Pentamidine--100-33-4; Therapeutic Class: (8:00); AHFS Class: Antiprotozoals pentamidine; References: 25; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2  - Patients with malignant disease complicated by diffuse interstitial pneumonia due to proved or suspected Pneumocystis carinii were given pentamidine in the dosage schedule recommended for this infection. By means of a sensitive method of assay, the plasma levels and urinary excretion of pentamidine during therapy were studied in these patients. Following the intramuscular administration of pentamidine, plasma levels were low and urinary excretion prolonged. After a single intraperitoneal injection in mice, the tissue distribution levels and excretion pattern for pentamidine were determined at various time intervals. There was storage of the drug in tissues and excretion was delayed. The highest concentration of pentamidine was found in the kidney. In mice pentamidine is eliminated primarily intact with little, if any, altered. The available data in man also suggested that pentamidine is retained, bound to tissues, and excreted over an extended period. Although renal abnormalities followed pentamidine, it was not possible to implicate the drug in all cases because of the seriousness of the illness and the concomitant use of other drugs. Pentamidine is useful in preventing disease due to \IT/Trypanosoma gambiense \OK/as well as effective in the treatment of diffuse interstitial pneumonia due to \IT/Pneumocystis carinii\OK/. The frequency of this type of pneumonia in cancer patients and in patients undergoing organ transplantation suggests the need for studies in animals and man.
KW  - Pentamidine--prevention-;
KW  - Antiprotozoals--pentamidine--prevention of interstitial pneumonia due to Pneumocystis carinii in patients with malignant disease, prevention of disease due to Trypanosoma gambiense;
KW  - Metabolism--pentamidine--in man and mice;
KW  - Drugs, body distribution--pentamidine--in man and mice;
KW  - Excretion--pentamidine--in man and mice;
KW  - Blood levels--pentamidine--in man and mice;
KW  - Tissue levels--pentamidine--in man and mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rao, G. S.;
T1  - Identity of peyocactin, an antibiotic from peyote (Lophophora williamsii), and hordenine
CT  - Identity of peyocactin, an antibiotic from peyote (Lophophora williamsii), and hordenine
JO  - Journal of Pharmacy and Pharmacology (England)
JF  - Journal of Pharmacy and Pharmacology (England)
Y1  - 1970/07/01/
VL  - 22
IS  - Jul
SP  - 544
EP  - 545
SN  - 03731022
AD  - Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-2864; Language: English; Trade Name: Peyocactin; Generic Name: Hordenine; Chemical Name: Hordenine--539-15-1; Therapeutic Class: (8:12); AHFS Class: Antibiotics hordenine; References: 9; Publication Type: Letters; Journal Coden: JPPMAB; Section Heading: Pharmaceutical Chemistry; Pharmacognosy; Abstract Author: Douglas L. Thompson
N2  - Based on data from the proton magnetic resonance spectrum, the mass spectrum of peyocactin was identified as N,N-dimethyl-p-hydroxyphenethylamine (hordenine). Furthermore, the IR spectra of peyocactin sulfate and hordenine sulfate were superimposable and their m.p. (197-198\DG/) was unaltered upon admixture.
KW  - Hordenine--analysis-;
KW  - Antibiotics--hordenine--identical to peyocactin;
KW  - Lophophora williamsii--peyocactin--constituents, identical to hordenine;
KW  - Analysis--peyocactin--constituents, L. williamsii, identical to hordenine;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chanock, R. M.;
T1  - Control of acute mycoplasmal and viral respiratory tract disease
CT  - Control of acute mycoplasmal and viral respiratory tract disease
JO  - Science
JF  - Science
Y1  - 1970/07/17/
VL  - 169
IS  - Jul 17
SP  - 248
EP  - 256
AD  - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
N1  - Accession Number: 8-0216; Language: English; References: 81; Journal Coden: SCIEAS; Section Heading: Pharmacology; Abstract Author: Robert A. Hall
N2  - The difficulties of design, immunological determinants of resistance and an evaluation of some vaccines for the control of acute mycoplasmal and viral respiratory tract disease are discussed in this review article. The prospects of eventual successful immunoprophylaxis through vaccination are reputedly encouraging.
KW  - Vaccines--acute mycoplasmal and viral respiratory tract disease--discussion;
KW  - Diseases--acute mycoplasmal and viral respiratory tract--vaccines;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Burbank, F.;
AU  - Fraumeni, J. F., Jr.;
T1  - Synthetic sweetener consumption and bladder cancer trends in the United States
CT  - Synthetic sweetener consumption and bladder cancer trends in the United States
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1970/07/18/
VL  - 227
IS  - Jul 18
SP  - 296
EP  - 297
AD  - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-1652; Language: English; References: 9; Journal Coden: NATUAS; Human Indicator: Yes; Section Heading: Toxicity; Sociology, Economics and Ethics; Abstract Author: Robert Alan Hall
N2  - Consumption patterns of cyclamates and the trends for bladder cancer in the United States are examined. Consumption of cyclamates increased from 2.7 million pounds in 1962 to 19.7 million pounds in 1969. Although there are differences in death rates for bladder cancer by race and sex, no clear cut break in either age specific or age adjusted rates has occurred since 1962. Incidence rates for bladder cancer from 2 states indicate a slow long-term increase; however, the increase may be due to another factor which increases the neoplasm: cigarette smoking.
KW  - Sweetening agents--cyclamates--carcinogenicity, consumption and bladder cancer trends, in U.S.;
KW  - Carcinogenicity--cyclamates--consumption patterns and bladder cancer trends, in U.S.;
KW  - Toxicity--cyclamates--carcinogenicity, consumption patterns and trends for bladder cancer, in U.S.;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Neva, F. A.;
AU  - Sheagren, J. N.;
AU  - Shulman, N. R.;
AU  - Canfield, C. J.;
T1  - Malaria: host-defense mechanisms and complications
CT  - Malaria: host-defense mechanisms and complications
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/08/01/
VL  - 73
IS  - Aug
SP  - 295
EP  - 306
SN  - 00034819
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3638; Language: English; Trade Name: Diaminodiphenylsulfone; Generic Name: Dapsone; Chemical Name: Chloroquine--54-05-7 Quinine--130-95-0 Pyrimethamine--58-14-0 Dapsone--80-08-0; References: 46; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Judith A. Kepler
N2  - The host-defense mechanisms and complications of malaria and the present status of chemotherapy of falciparum infections are reviewed. Response to various treatment regimens using the following drugs is discussed: chloroquine, quinine, pyrimethamine, various sulfonamides, and diaminodiphenylsulfone (dapsone).
KW  - Chloroquine--malaria-;
KW  - Quinine--malaria-;
KW  - Pyrimethamine--malaria-;
KW  - Dapsone--malaria-;
KW  - Malaria--therapy--host-defense mechanisms and complications, present status of chemotherapy;
KW  - Sulfonamides--malaria--therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gottlieb, J. A.;
AU  - Serpick, A. A.;
T1  - Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors
CT  - Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/08/01/
VL  - 30
IS  - Aug
SP  - 2132
EP  - 2138
SN  - 00085472
AD  - Medical Service, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland 21211
N1  - Accession Number: 8-0583; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 21; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - This article reports the use of methotrexate in the treatment of acute leukemia and of solid tumors including those of the testis. Five patients with previously treated acute leukemia received 14 courses of a 24-hour I.V. infusion of a 2 mg./kg. dose of methotrexate followed by 6 mg. of leucovorin. Four additional leukemia patients, previously treated, and 10 other patients with various metastatic solid tumors, largely choriogonadotropin-producing testicular tumors, received 24 courses of methotrexate at 5 mg./kg., with 60% given as a rapid I.V. injection, followed by the remaining 40% given as a 4-hour infusion. The last regimen was repeated on 2 consecutive days, and no leucovorin was given. Courses were generally repeated at 2-week intervals. Two of the 8 evaluable choriogonadotropin-producing tumors had complete remissions lasting 3 months and 18+ months. Four others responded solely with a decrease in urinary gonadotropin levels, while 2 more exhibited small decreases in the size of metastatic lesions. No complete remissions were seen in the leukemic patients, although marked decreases in the number of peripheral and bone marrow blasts were almost always observed. Two elderly leukemia patients tolerated the 24-hour infusions exceptionally well. No response was seen in a patient with squamous cell carcinoma of the lung.
KW  - Methotrexate--therapy-;
KW  - Antineoplastic agents--methotrexate--therapy, of acute leukemia and of solid tumors;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Abelson, H. T.;
AU  - Rabstein, L. S.;
T1  - Influence of prednisolone on Moloney leukemogenic virus in BALB/\LC/c\UC/ mice
CT  - Influence of prednisolone on Moloney leukemogenic virus in BALB/\LC/c\UC/ mice
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/08/01/
VL  - 30
IS  - Aug
SP  - 2208
EP  - 2212
SN  - 00085472
AD  - Laboratory of Viral Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-3101; Language: English; Chemical Name: Prednisolone--50-24-8; References: 35; Journal Coden: CNREA8; Section Heading: Toxicity
N2  - This paper reports efforts to influence the outcome of Moloney leukemia virus infection in BALB/c mice by the long-term administration of prednisolone. Long-term administration of prednisolone to BALB/c mice alters the reactivity of their lymphoid tissue to the oncogenic effects of Moloney leukemia virus. Solid lymphosarcoma or granulocytic leukemia is produced in a significant number of the treated mice. The alteration in disease response may be attributed to a prednisolone-induced simulated thymectomy.
KW  - Prednisolone--effects-;
KW  - Toxicity--prednisolone--effects, on Moloney leukemogenic virus, in mice, long-term administration;
KW  - Carcinogens--prednisolone--effects, on Moloney leukemogenic virus, in mice, long-term administration;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06132-005
AN  - 2006-06132-005
AU  - Yarrow, Leon J.
T1  - Ethology, Control Systems, Psychoanalysis and Mother Love.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1970/08//
VL  - 15
IS  - 8
SP  - 493
EP  - 494
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06132-005. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Attachment Behavior; Mother Child Communication; Mother Child Relations; Psychoanalysis. Minor Descriptor: Love; Mothers; Psychoanalytic Theory. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Bowlby, John. Attachment and Loss: Vol. I: Attachment=New York: Basic Books, 1969. Pp. xx + 428. $8.50; 1969. Page Count: 2. Issue Publication Date: Aug, 1970. 
AB  - Reviews the book, Attachment and Loss: Vol. I: Attachment by John Bowlby (1969). In this volume the author takes a dispassionate view of the mother-child attachment and analyzes its roots. His views on the development of the bond between mother and child have been evolving over the past twenty years. The task that author has set for himself, the integration of these diverse themes into a coherent theory of the origins of attachment, is clearly a prodigious intellectual feat. The basic concepts of each theoretical position are developed with great clarity, and there is an orderly systematic progression of ideas; but when the author attempts to blend the components, he is not so successful. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mother child relationship
KW  - mother child attachment
KW  - mother love
KW  - psychoanalysis
KW  - 1970
KW  - Attachment Behavior
KW  - Mother Child Communication
KW  - Mother Child Relations
KW  - Psychoanalysis
KW  - Love
KW  - Mothers
KW  - Psychoanalytic Theory
KW  - 1970
U2  - Bowlby, John. (1969); Attachment and Loss: Vol. I: Attachment; New York: Basic Books, 1969. Pp. xx + 428. $8.50
DO  - 10.1037/013813
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06132-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06132-012
AN  - 2006-06132-012
AU  - Senders, Virginia L.
T1  - Right But Trite.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1970/08//
VL  - 15
IS  - 8
SP  - 505
EP  - 506
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06132-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Senders, Virginia L.; National Institute of Mental Health, McLean Hospital, Belmont, MA, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Females; Middle Class; Mothers; Values. Minor Descriptor: Messages; Trends. Classification: Sex Roles & Women's Issues (2970). Population: Human (10). Reviewed Item: Harbeson, Gladys E. Choice and Challenge for the American Woman=Cambridge, Mass.: Schenkman, 1967. Pp. xvii + 185. $7.95; 1967. Page Count: 2. Issue Publication Date: Aug, 1970. 
AB  - Reviews the book, Choice and Challenge for the American Woman by Gladys E. Harbeson (see record [rid]1969-14176-000[/rid]). The author wrote the book, she says, because she felt that information about changing trends in women's lives should be made available to a wider range of readers than had previously received it, and she hoped to present 'suggestions for formulating a theory of values which could assist the individual in her adaptation to the new patterns.' Despite its title, the book's message is limited to upper-middle-class, educated women. The author should not be criticized for this limitation, but it is harder to understand her failure to discuss the effects on women's lives of population explosion, with its implied devaluation of the mother's role, or information explosion, with its accompaniment of rapid professional obsolescence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - American woman
KW  - women lives
KW  - theory of values
KW  - choice and challenge
KW  - 1970
KW  - Human Females
KW  - Middle Class
KW  - Mothers
KW  - Values
KW  - Messages
KW  - Trends
KW  - 1970
U2  - Harbeson, Gladys E. (1967); Choice and Challenge for the American Woman; Cambridge, Mass.: Schenkman, 1967. Pp. xvii + 185. $7.95
DO  - 10.1037/013820
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06132-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Brown, C. H., III;
AU  - Canellos, G. P.;
AU  - Carbone, P. P.;
T1  - Effect of L-asparaginase on mouse bone marrow, assayed by in vitro culture
CT  - Effect of L-asparaginase on mouse bone marrow, assayed by in vitro culture
JO  - Blood
JF  - Blood
Y1  - 1970/09/01/
VL  - 36
IS  - Sep
SP  - 385
EP  - 389
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-3889; Language: English; Chemical Name: Asparaginase--9015-68-3; References: 13; Journal Coden: BLOOAW; Section Heading: Pharmacology; Abstract Author: Jimmie L. Hall
N2  - The effect of asparaginase on mouse hemopoietic cell function was examined. Asparaginase was administered to mice in doses of 10, 100, 1000 or 10,000 I.U. per kg., and the bone marrow was cultured 4 or 24 hours later. Marrow cellularity and the number of in vitro colony forming units were reduced with all doses at 4 hours. Only the highest dose, however, resulted in any suppression at 24 hours. These results suggest that normal bone marrow cells can adapt to the L-asparagine depletion induced by L-asparaginase.
KW  - Asparaginase--effects-;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3889&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Shapiro, W. R.;
AU  - Ausman, J. I.;
AU  - Rall, D. P.;
T1  - Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea, cyclophosphamide, mithramycin, and methotrexate
CT  - Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea, cyclophosphamide, mithramycin, and methotrexate
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/09/01/
VL  - 30
IS  - Sep
SP  - 2401
EP  - 2413
SN  - 00085472
AD  - Office of the Associate Scientific Director for Experimental Therapeutics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-1110; Language: English; Trade Name: Urea; Generic Name: Carmustine; Chemical Name: Carmustine--154-93-8 Cyclophosphamide--6055-19-2 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents mithramycin (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 50; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology
N2  - The antineoplastic effects of carmustine, cyclophosphamide, mithramycin, and methotrexate were determined in mice with implanted carcinogen-induced gliomas. Carmustine significantly prolonged the life span of the mice. Cyclophosphamide was less effective, while mithramycin and methotrexate had no observable effect. The implications of these results with respect to blood-brain barrier, brain tumor permeability, and the value of the model as a screen for human brain tumor chemotherapy are discussed.
KW  - Carmustine--effects-;
KW  - Cyclophosphamide--effects-;
KW  - Mithramycin--effects-;
KW  - Methotrexate--effects-;
KW  - Antineoplastic agents--carmustine--effects, in mice with implanted carcinogen-induced gliomas;
KW  - Antineoplastic agents--cyclophosphamide--effects, in mice with implanted carcinogen-induced gliomas;
KW  - Antineoplastic agents--mithramycin--effects, lack, in mice with implanted carcinogen-induced gliomas;
KW  - Antineoplastic agents--methotrexate--effects, lack, in mice with implanted carcinogen-induced gliomas;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1110&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Watanabe, A. M.;
AU  - Chase, T. N.;
AU  - Cardon, P. V.;
T1  - Effect of L-dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes
CT  - Effect of L-dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1970/09/01/
VL  - 11
IS  - Sep-Oct
SP  - 740
EP  - 746
SN  - 00099236
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 8-1663; Language: English; Trade Name: Dopa; Generic Name: Levodopa; Chemical Name: Levodopa--59-92-7; References: 17; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2  - L-Dopa (levodopa) produced a significant reduction in recumbent and standing blood pressure in patients with neurologic or psychiatric disorders. The addition of an extracerebral decarboxylase inhibitor potentiated this effect. Reflex forearm arteriolar and venous constriction was present during therapy with L-dopa alone or in combination with the decarboxylase inhibitor, but there was an attenuation of reflex forearm arteriolar constriction. It is suggested that the hypotensive effect of L-dopa may be mediated through the central nervous system.
KW  - Levodopa--effects-;
KW  - Drug interactions--levodopa--effects, alone and combined with extracerebral decarboxylase inhibitor, on blood pressure and cardiovascular reflexes;
KW  - Enzyme inhibitors--decarboxylase inhibitor--and levodopa, effects on blood pressure and cardiovascular reflexes;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1663&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lancaster, F. W.
AU  - Jenkins, Grace T.
T1  - u Quality Control" Applied to the Operations of a Large Information System.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
Y1  - 1970/09//Sep/Oct1970
VL  - 21
IS  - 5
M3  - Article
SP  - 370
EP  - 371
SN  - 00028231
AB  - The recent evaluation of Medlars has shown that it is possible to undertake an investigation to measure the effectiveness of a large mechanized retrieval system and to identify the factors that are most important in controlling and limiting the effectiveness of the system. A one-time evaluation, however, can only measure the performance of a system at a particular point in time. When changes are made to the system, as a result of the investigation, we would like to be able to estimate the effects of those changes. Moreover, a one-time evaluation, however comprehensive, cannot identify all sources of system failure. It can locate the most important sources and the areas of greatest weakness, but it cannot identify, for example, all specific instances of vocabulary inadequacy in the system.
KW  - INFORMATION storage & retrieval systems
KW  - QUALITY control
KW  - FACTORY management
KW  - MEDLARS
KW  - MEDICINE
KW  - WEIGHTS & measures
N1  - Accession Number: 16748114; Lancaster, F. W. 1; Jenkins, Grace T. 2; Affiliations: 1: Graduate School of Library Science University of Illinois Urbana, Illinois.; 2: Bibliographic Services Division National Library of Medicine National Institutes of Health Bethesda, Maryland.; Issue Info: Sep/Oct1970, Vol. 21 Issue 5, p370; Thesaurus Term: INFORMATION storage & retrieval systems; Thesaurus Term: QUALITY control; Thesaurus Term: FACTORY management; Subject Term: MEDLARS; Subject Term: MEDICINE; Subject Term: WEIGHTS & measures; Number of Pages: 2p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16748114&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2009-11543-003
AN  - 2009-11543-003
AU  - Katz, Martin M.
AU  - Sanborn, Kenneth O.
AU  - Gudeman, Howard
T1  - Characterizing differences in psychopathology among ethnic groups in Hawaii.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1970///Fal 1970
VL  - 1
IS  - 2
SP  - 20
EP  - 29
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11543-003. Partial author list: First Author & Affiliation: Katz, Martin M.; Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the Association for Research on Mental and Nervous Diseases, Dec, 1967, New York, NY, US. Conference Note: An earlier version of this article was presented at the aforementioned conference. Major Descriptor: Psychopathology; Psychosis; Racial and Ethnic Differences. Minor Descriptor: Hospitalized Patients. Classification: Psychological Disorders (3210). Population: Human (10); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Mental Status Schedule; Inpatient Multidimensional Psychiatric Rating Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Fal 1970. 
AB  - The most general aim of this research, as a comparative study in culture and psychopathology, is the establishing of valid, objective pictures of the psychopathology of particular ethnic groups. Specifically, there is interest in (1) whether various ethnic groups, in this case Hawaii-Japanese, Hawaii-Filipinos, Hawaii-Caucasians, and Part-Hawaiians, manifest functional psychosis differently; (2) whether these differences are consistent with those found in previous studies or with what might be expected from an understanding of normal personality in these ethnic groups; (3) whether these differences are consistent across different settings (i.e., will the differences which appear in their social behavior and symptomatology in the community be the same as those which appear when they are in the hospital?); and (4) whether there are ways in which all these groups of functional psychotics are the same. The study sample of patients represented all admissions to Hawaii State Hospital for functional disorders, excluding alcoholics, between the ages of 20 and 50 during a given year. The psychopathology of each patient was to be studied both in the community and in the hospital. For purposes of this presentation, the results of the comparison of the Japanese and the Caucasians will be briefly summarized as a means of demonstrating how we go about attempting to establish valid pictures of the psychopathology of the various ethnic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychopathology
KW  - Hawaiian ethnic groups
KW  - ethnic differences
KW  - psychosis
KW  - community settings
KW  - hospital settings
KW  - 1970
KW  - Psychopathology
KW  - Psychosis
KW  - Racial and Ethnic Differences
KW  - Hospitalized Patients
KW  - 1970
DO  - 10.1093/schbul/1.2.20
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11543-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Katz, E.;
AU  - Grimley, P.;
AU  - Moss, B.;
T1  - Reversal of antiviral effects of rifampicin
CT  - Reversal of antiviral effects of rifampicin
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1970/09/05/
VL  - 227
IS  - Sep 5
SP  - 1050
EP  - 1051
AD  - National Institute of Allergy and Infectious Diseases, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 9-2647; Language: English; Trade Name: Rifampicin; Generic Name: Rifampin; Chemical Name: Rifampin--13292-46-1; Therapeutic Class: (8:18); AHFS Class: Virucides rifampin; References: 14; Journal Coden: NATUAS; Section Heading: Pharmacology; Abstract Author: Robert Alan Hall
N2  - The sequence of events following removal of rifampicin (rifampin) is examined to correlate effects observed on formation of late particulate RNA polymerase activity and on the assembly of viral envelopes. Rifampicin treated HeLa cells were infected with vaccina virus. After 8 hours the drug was removed. The cells were resuspended in warm medium and samples removed at intervals were examined by electron microscopy. Late particulate RNA polymerase activity could not be demonstrated until after the rifampicin effect on the formation of the viral envelope was completely reversed.
KW  - Rifampin--effects-;
KW  - Virucides--rifampin--effects, antiviral, reversal;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-2647&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Van Thiel, D. H.;
AU  - Ross, G. T.;
AU  - Lipsett, M. B.;
T1  - Pregnancies after chemotherapy of trophoblastic neoplasms
CT  - Pregnancies after chemotherapy of trophoblastic neoplasms
JO  - Science
JF  - Science
Y1  - 1970/09/25/
VL  - 169
IS  - Sep 25
SP  - 1326
EP  - 1327
AD  - National Cancer Institute, National Institues of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-2573; Language: English; Chemical Name: Methotrexate--59-05-2 Dactinomycin--50-76-0 Vinblastine--865-21-4 Mechlorethamine--51-75-2 Norleucine--327-57-1; References: 13; Journal Coden: SCIEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Robert A. Hall
N2  - Eighty-eight pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents were examined. Cytotoxic agents used singly or in combinations were: methotrexate, actinomycin-D (dactinomycin), vinblastine, nitrogen mustard (mechlorethamine) and 6-diazo-norleucine. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present.
KW  - Methotrexate--toxicity-;
KW  - Dactinomycin--toxicity-;
KW  - Vinblastine--toxicity-;
KW  - Mechlorethamine--toxicity-;
KW  - Norleucine--6-diazo--;
KW  - Toxicity--antineoplastic agents--lack, on subsequent pregnancies, in women;
KW  - Antineoplastic agents--toxicity--lack, on subsequent pregnancies, in women;
KW  - Teratogenicity--antineoplastic agents--lack, in pregnant women previously treated for gestational trophoblastic neoplasms;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-2573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Aronoff, M. S.;
AU  - Epstein, R. S.;
T1  - Factors associated with poor response to lithium carbonate: a clinical study
CT  - Factors associated with poor response to lithium carbonate: a clinical study
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1970/10/01/
VL  - 127
IS  - Oct
SP  - 472
EP  - 480
SN  - 0002953X
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Chevy Chase, Maryland
N1  - Accession Number: 8-0826; Language: English; Chemical Name: Lithium carbonate--554-13-2 Lithium--7439-93-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 24; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - The characteristics of manic patients who have had a poor or irregular response to lithium therapy is presented. Eighteen patients with intermittent manic illness were treated with lithium on a regular basis for an average of 2 years. Lithium salts appear to predictably and reversibly alter mood state at blood levels that cause no general sedation or tranquilization, unlike the phenothiazines. The effectiveness of the lithium ion in the treatment of acute and recurrent manic illness has been well established by several double-blind studies and by 20 years of clinical experience. These studies, however, report a poor response to lithium in 20 to 40% of patients treated for mania. Because of the interest in lithium as a research tool in the study of affective illness, it is important to determine why this ion is not always therapeutically effective.
KW  - Lithium carbonate--mania-;
KW  - Lithium--mania-;
KW  - Psychotherapeutic agents--lithium carbonate--mania, therapy, characteristics of patients with poor or irregular response;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0826&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Fales, H. M.;
AU  - Milne, G. W. A.;
AU  - Axenrod, T.;
T1  - Identification of barbiturates by chemical ionization mass spectrometry
CT  - Identification of barbiturates by chemical ionization mass spectrometry
JO  - Anal. Chem.
JF  - Anal. Chem.
Y1  - 1970/10/01/
VL  - 42
IS  - Oct
SP  - 1432
EP  - 1435
AD  - Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 7-4179; Language: English; Trade Name: Nembutal--Seconal--Amytal--Phanlodorn--Ortal--Alurate; Generic Name: Pentobarbital; Secobarbital; Amobarbital; Cyclobarbital; Hexethal; Aprobarbital; Chemical Name: Pentobarbital--76-74-4 Phenobarbital--50-06-6 Amobarbital--57-43-2 Cyclobarbital--52-31-3 Secobarbital--76-73-3 Butalbital--77-26-9 Aprobarbital--77-02-1; References: 13; Journal Coden: ANCHAM; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2  - The electron impact and chemical ionization mass spectra of the following 8 barbiturates were studied; aprobarbital, secobarbital (Seconal), butalbital (Alurate), pentobarbital (Nembutal), hexethal (Ortal), phenobarbital, amobarbital (Amytal) and cyclobarbital (Phanlodorn.) It was concluded that, because of the very large cross section for proton capture possessed by the barbituric acid nucleus, quasimolecular ions derived from barbiturates in chemical ionization mass spectrometry are very intense and can be used to help identify the specific barbiturates. The value of this method in an actual case of drug identification has been demonstrated.
KW  - Pentobarbital--analysis-;
KW  - Hexethal--analysis-;
KW  - Phenobarbital--analysis-;
KW  - Amobarbital--analysis-;
KW  - Cyclobarbital--analysis-;
KW  - Secobarbital--analysis-;
KW  - Butalbital--analysis-;
KW  - Aprobarbital--analysis-;
KW  - Analysis--barbiturates--chemical ionization mass spectrometry;
KW  - Barbiturates--analysis--chemical ionization mass spectrometry;
KW  - Spectrometry--mass--chemical ionization, identification of barbiturates;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4179&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bennett, J. E.;
T1  - Clotrimazole: new drug for systemic mycoses?
CT  - Clotrimazole: new drug for systemic mycoses?
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/10/01/
VL  - 73
IS  - Oct
SP  - 653
EP  - 654
SN  - 00034819
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 7-4569; Language: English; Chemical Name: Clotrimazole--23593-75-1; Therapeutic Class: (8:12.04); AHFS Class: Fungicides clotrimazole; References: 5; Publication Type: Editorial Notes; Journal Coden: AIMEAS; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Judith A. Kepler
N2  - A critical review of the data on clotrimazole, a new antifungal agent, is presented.
KW  - Clotrimazole--fungicide-;
KW  - Fungicides--clotrimazole--discussion;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4569&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodwin, F. K.;
AU  - Murphy, D. L.;
AU  - Brodie, H. K. H.;
AU  - Bunney, W. E., Jr.;
T1  - L-Dopa, catecholamines, and behavior: a clinical and biochemical study in depressed patients
CT  - L-Dopa, catecholamines, and behavior: a clinical and biochemical study in depressed patients
JO  - Biol. Psychiatry
JF  - Biol. Psychiatry
Y1  - 1970/10/01/
VL  - 2
IS  - Oct
SP  - 341
EP  - 363
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 8-0885; Language: English; Chemical Name: Levodopa--59-92-7; References: 76; Journal Coden: BIPCBF; Human Indicator: Yes; Section Heading: Pharmacology
N2  - L-Dopa (levodopa) was administered in large oral doses to 16 depressed patients under double-blind conditions to evaluate the possible effects of this catecholamine precursor on mood and behavior. The dosages used were equivalent to those which produce behavioral effects and brain amine changes in animals, as well as being equal to those recently found to be therapeutic in Parkinson's disease. Changes in cerebrospinal fluid and urinary catecholamine and indoleamine metabolites, and in cortical evoked potential measurements provide suggestive evidence that L-dopa altered catecholamines both in brain and the periphery. The consistent induction of hypomania or mania in all 5 of the depressed patients who had prior histories of mania suggests that catecholamines, especially dopamine, may be directly involved in the genesis, or triggering, of manic behavior in susceptible individuals.
KW  - Levodopa--effects-;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0885&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levin, V. A.;
AU  - Shapiro, W. R.;
AU  - Clancy, T. P.;
AU  - Oliverio, V. T.;
T1  - Uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma
CT  - Uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/10/01/
VL  - 30
IS  - Oct
SP  - 2451
EP  - 2455
SN  - 00085472
AD  - Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-1109; Language: English; Chemical Name: Urea--57-13-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents urea; References: 17; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Abstract Author: Jimmie L. Hall
N2  - The purposes of this experiment were to determine in mice the tumor and brain distribution of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and to test its antineoplastic activity against implanted brain tumors. Uptake and distribution studies indicate that CCNU has relatively constant tissue/plasma ratio levels. The life-span of tumor-bearing animals was increased by CCNU from 2- to 4-fold, depending on the dose used and the type of tumor. Although few conclusions can be made regarding the mode of action of CCNU, further consideration of its use in the treatment of human gliomas seems warranted.
KW  - Urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso--;
KW  - Antineoplastic agents--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, absorption, distribution, and activity, in the murine glioma;
KW  - Absorption--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
KW  - Drugs, body distribution--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
KW  - Metabolism--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, absorption, distribution, and antineoplastic activity, in the murine gioma;
KW  - Tissue levels--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
KW  - Blood levels--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bonadonna, G.;
AU  - Monfardini, S.;
AU  - De Lena, M.;
AU  - Fossati-Bellani, F.;
AU  - Beretta, G.;
T1  - Phase I and preliminary phase II evaluation of adriamycin (NSC-123127)
CT  - Phase I and preliminary phase II evaluation of adriamycin (NSC-123127)
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/10/01/
VL  - 30
IS  - Oct
SP  - 2572
EP  - 2582
SN  - 00085472
AD  - reprints: Instituto Nazionale dei Tumori, Via Venezian, 1, 20133, Italy
AD  - The Clinical Chemotherapy Unit, National Cancer Institute, Milan, Italy
N1  - Accession Number: 8-0994; Language: English; Trade Name: NSC-123127; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 22; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Jimmie L. Hall
N2  - This article describes a phase I and early phase II evaluation of the antineoplastic effects of adriamycin in 155 patients with various types of neoplastic disease. Adriamycin was administered in a rapid, single I.V. injection at doses of 0.4, 0.65, or 0.8 mg./kg. It was also sometimes given intrapleurally or intra-arterially. Appreciable responses were seen in acute lymphoblastic leukemia, chronic myeloid leukemia, neuroblastoma, Ewing's sarcoma, seminoma, soft tissue sarcomas, and various types of malignant lymphomas. However, complete remission was observed in only a few cases despite the fact that tumor regression started after only a few doses. Toxicity consisted primarily of stomatitis, bone marrow depression, and alopecia. The results indicate that adriamycin is active in many forms of neoplastic disease, and that it is more useful in inducing regressions than as maintenance therapy.
KW  - Doxorubicin--neoplastic diseases-;
KW  - Antineoplastic agents--doxorubicin--neoplastic diseases, phase I and preliminary phase II evaluation;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Joseph, W. L.;
AU  - Melewicz, F.;
AU  - Morton, D. L.;
T1  - Spontaneous development of mammary adenocarcinoma following prolonged immunosuppression in the dog
CT  - Spontaneous development of mammary adenocarcinoma following prolonged immunosuppression in the dog
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1970/10/01/
VL  - 30
IS  - Oct
SP  - 2606
EP  - 2608
SN  - 00085472
AD  - Tumor Immunology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-3546; Language: English; Chemical Name: Azathioprine--446-86-6 Methylprednisolone--83-43-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents azathioprine (92:00); AHFS Class: Immunosuppressive agents methylprednisolone; References: 8; Journal Coden: CNREA8; Section Heading: Toxicity; Abstract Author: Jimmie L. Hall
N2  - This communication reports the apparent spontaneous development in a laboratory animal of a mammary adenocarcinoma while being treated with immunosuppressants. An adult female mongrel dog developed the tumors while on a regimen of azathioprine and methylprednisolone.
KW  - Azathioprine--and methylprednisolone-;
KW  - Methylprednisolone--and azathioprine-;
KW  - Immunosuppressive agents--azathioprine--and methylprednisolone, mammary adenocarcinoma following prolonged immunosuppression, in dog;
KW  - Immunosuppressive agents--methylprednisolone--and azathioprine, mammary adenocarcinoma following prolonged immunosuppression, in dog;
KW  - Toxicity--azathioprine--and methylprednisolone, mammary adenocarcinoma following prolonged immunosuppression, in dog;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Coe, J.E.
AU  - Peel, L. F.
T1  - Antibody Production in the Bullfrog (<em>Rana catesbeiana</em>.
JO  - Immunology
JF  - Immunology
Y1  - 1970/10//
VL  - 19
IS  - 4
M3  - Article
SP  - 539
EP  - 550
SN  - 00192805
AB  - Serum antibody was found by radioimmunoelectrophoresis (RIEP) in thirty-one of thirty-five bullfrogs (BF) immunized with one of four protein antigens. Rabbit γ globulin (RGG) and hen egg albumin were the best antigens, whereas human serum albumin and bovine serum albumin induced a less consistent immune response. Although a IgM to IgG sequence of antibody production usually was detected with RGG as antigen, a similar sequence was infrequent with the other antigens and the initial response was usually a IgG antibody. IgM antibody was detected in the serum for a prolonged interval (>100 days) and precipitating quantities of IgG antibody were found more than 1 year after antigen inoculation. As measured by haemagglutination, the IgM antibody was routinely inactivated by mercaptoethanol (ME) treatment and IgG antibody was frequently inactivated by ME, although it still had antigen binding capacity by RIEP. IgG hemagglutinins, which were resistant to ME treatment, were found in some sera obtained from BF after booster injections of antigen. Immunoelectrophoretic examination of normal or immune BF sera revealed a prominent precipitin line of slow γ-mobility which did not bind 131I-labelled antigen but did bind 59Fe. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - BULLFROG
KW  - ANTIGENS
KW  - PRECIPITIN reaction
KW  - IMMUNITY
KW  - ADMINISTRATION of drugs
N1  - Accession Number: 13360207; Coe, J.E. 1; Peel, L. F. 1; Source Information: Oct70, Vol. 19 Issue 4, p539; Subject: IMMUNOGLOBULINS; Subject: BULLFROG; Subject: ANTIGENS; Subject: PRECIPITIN reaction; Subject: IMMUNITY; Subject: ADMINISTRATION of drugs; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Knorr, D. W. R.;
AU  - Kirschner, M. A.;
AU  - Taylor, J. P.;
T1  - Estimation of estrone and estradiol in low level urines using electron-capture gas-liquid chromatography
CT  - Estimation of estrone and estradiol in low level urines using electron-capture gas-liquid chromatography
JO  - J. Clin. Endocrinol. Metab.
JF  - J. Clin. Endocrinol. Metab.
Y1  - 1970/10/01/
VL  - 31
IS  - Oct
SP  - 409
EP  - 416
AD  - reprints: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, New Jersey 07112
AD  - Endocrinology Branch, National Cancer Institute, Bethesda, Maryland
N1  - Accession Number: 8-0926; Language: English; Chemical Name: Estrone--53-16-7 Estradiol--50-28-2; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
KW  - Estrone--and estradiol-;
KW  - Estradiol--and estrone-;
KW  - Metabolism--estrone--analysis, in urine;
KW  - Metabolism--estradiol--analysis, in urine;
KW  - Chromatography, gas--estrogens--urinalysis of estrone and estradiol;
KW  - Estrogens--chromatography, gas--urinalysis of estrone and estradiol;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-40706-020
AN  - 2013-40706-020
AU  - Torrey, E. Fuller
T1  - Review of Teaching as a subversive activity.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1970/10//
VL  - 40
IS  - 5
SP  - 885
EP  - 886
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40706-020. Partial author list: First Author & Affiliation: Torrey, E. Fuller; Div. of Manpower & Training, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Curriculum; Education; Teaching. Minor Descriptor: Mental Health Personnel. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Reviewed Item: Postman, Neil; Weingartner, Charles. Teaching as a subversive activity=New York: Delacorte Press. 218 pp. $5.95; 1969. Page Count: 2. Issue Publication Date: Oct, 1970. 
AB  - Reviews the book, Teaching as a Subversive Activity by Neil Postman and Charles Weingartner (1969). Any mental health worker concerned with the institution of education should read this book. It describes vividly the wasteland that we put under that label and the bleak process whereby we produce 'intellectual paraplegics.' The book is more than a critique of education, however. It suggests as a paradigm that we use the student as the starting point, rather than some theoretical body of truth. The authors also attack the content of the current curriculum, which they maintain 'is largely designed to keep students from knowing themselves and their environment in any realistic sense; which is to say, it does not allow inquiry into most of the critical problems that comprise the content of the world outside the school.' For mental health professionals, the book implicitly raises disturbing questions. The book may be faulted for its loose construction in parts and for not supplying a bibliography. Overall the book is enjoyable, highly readable, and above all subversive in that it advocates that people actually think. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - teaching
KW  - subversive activity
KW  - education
KW  - curriculum
KW  - mental health professionals
KW  - 1970
KW  - Curriculum
KW  - Education
KW  - Teaching
KW  - Mental Health Personnel
KW  - 1970
U2  - Postman, Neil; Weingartner, Charles. (1969); Teaching as a subversive activity; New York: Delacorte Press. 218 pp. $5.95
DO  - 10.1037/h0097609
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ng, K. Y.;
AU  - Chase, T. N.;
AU  - Colburn, R. W.;
AU  - Kopin, I. J.;
T1  - L-dopa induced release of cerebral monoamines
CT  - L-dopa induced release of cerebral monoamines
JO  - Science
JF  - Science
Y1  - 1970/10/02/
VL  - 170
IS  - Oct 2
SP  - 76
EP  - 77
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-3254; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 13; Journal Coden: SCIEAS; Section Heading: Pharmacology
N2  - L-Dopa (levodopa) markedly increased the efflux of tritiated dopamine and tritiated serotonin from rat brain slices. This action appeared contingent on the decarboxylation of L-dopa to dopamine, since it could be blocked by an inhibitor of L-amino acid decarboxylase. Selective destruction of catecholamine containing nerve terminals by 6-hydroxydopamine significantly decreased the uptake and release of tritiated dopamine but not that of tritiated serotonin.
KW  - Levodopa--effects-;
KW  - Antiparkinson agents--levodopa--effects, induced release of cerebral monoamines, from rat brain slices;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Epstein, E.;
AU  - Ugel, A. R.;
T1  - Effects of topical mechlorethamine on skin lesions of psoriasis
CT  - Effects of topical mechlorethamine on skin lesions of psoriasis
JO  - Archives of Dermatology (USA)
JF  - Archives of Dermatology (USA)
Y1  - 1970/11/01/
VL  - 102
IS  - Nov
SP  - 504
EP  - 506
SN  - 0003987X
AD  - Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 9-3195; Language: English; Trade Name: Mustargen; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine; References: 12; Journal Coden: ARDEAC; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Persis Mehta
N2  - The effectiveness of topical applications of aqueous solutions of mechlorethamine (Mustargen) hydrochloride on 12 patients with resistant psoriasis was determined in a double-blind study. Initial hypersensitivity tests using 0.1 to 50 mg./100 ml. of mechlorethamine HCl in all patients were negative, hence the patients were treated with weekly applications of 50 mg./100 ml. of the drug on one side of the body and placebo (lactose solution) on the other side. Ten patients showed definite improvement on the side treated with mechlorethamine and not on the other. Although no systemic toxicity was detected (as determined by several parameters), 9 patients in all became sensitized to the drug after 4 to 40 applications. Hence, a new double-blind study was designed in which the dosage was lowered to 0.5 mg./100 ml. of solution applied daily to previously untreated areas. No improvement was obtained either with the active drug or with lactose in the concentrations used. Local hypersensitivity was manifested by edema, erythema, pruritis and vesiculation and subsided within 7 to 10 days. Local hyperpigmentation was observed in some cases and usually persisted for no longer than one month after cessation of therapy.
KW  - Mechlorethamine--hydrochloride-;
KW  - Antineoplastic agents--mechlorethamine--hydrochloride, psoriasis, therapy, topical, lack of effect, in patients;
KW  - Topical preparations--mechloethamine--hydrochloride, psoriasis, therapy, lack of effect, in patients;
KW  - Psoriasis--mechlorethamine--hydrochloride, therapy, topical, lack of effect, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - ADAMSON, RICHARD H.
T1  - The Cancer Problem: A Critical Analysis and Modern Synthesis.
JO  - BioScience
JF  - BioScience
Y1  - 1970/11//11/1/1970
VL  - 20
IS  - 21
M3  - Book Review
SP  - 1178
EP  - 1178
SN  - 00063568
AB  - The article reviews the book "The Cancer Problem: A Critical Analysis and Modern Synthesis," by A. C. Braun.
KW  - Cancer
KW  - Nonfiction
KW  - Braun, A. C.
KW  - Cancer Problem: A Critical Analysis & Modern Synthesis, The (Book)
N1  - Accession Number: 32099520; ADAMSON, RICHARD H. 1; Affiliations: 1 : National Institutes of Health, Bethesda, Md.;  Source Info: 11/1/1970, Vol. 20 Issue 21, p1178; Subject Term: Cancer; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Steinberg, Alfred D.
AU  - Talal, Norman
T1  - SUPPRESSION OF ANTIBODIES TO NUCLEIC ACIDS WITH POLYINOSINICPOLYCYTIDYLIC ACID AND CYCLOPHOSPHAMIDE IN MURINE LUPUS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1970/11//
VL  - 7
IS  - 5
M3  - Article
SP  - 687
EP  - 691
SN  - 00099104
AB  - NZB/NZW mice with active lupus were treated with polyinosinic-polycytidylic acid, a synthetic double stranded RNA, followed by cyclophosphamide to induce immunologic tolerance to nucleic acids, This combined regimen reduced serum antibodies to RNA and DNA to a greater degree than did cyclophosphamide alone. This report demonstrates that a specific Form of immunotherapy can he successfully employed to treat the serologic abnormalities of murine lupus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - NUCLEIC acids
KW  - RNA
KW  - LUPUS erythematosus
KW  - DNA
KW  - IMMUNOTHERAPY
N1  - Accession Number: 14587273; Steinberg, Alfred D. 1,2; Talal, Norman 1,2; Source Information: Nov70, Vol. 7 Issue 5, p687; Subject: IMMUNOGLOBULINS; Subject: NUCLEIC acids; Subject: RNA; Subject: LUPUS erythematosus; Subject: DNA; Subject: IMMUNOTHERAPY; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Jacobson, Arthur E
AU  - Kaufmann, S Joel
AU  - Raub, William F
T1  - Computer-assisted data management in medicinal chemistry-the use of a general-purpose text editor
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1970/11//
VL  - 10
IS  - 4
M3  - Article
SP  - 248
EP  - 255
SN  - 00219576
AB  - Wylbur, an interactive computer-based text-editor for the ibm 360/65, has been utilized as a chemical/biological information-handling system. Its applicability is illustrated with chemical and biological data on the 3-benzazocines (6, 7-benzomorphans), a class of strong analgetics in which a separation of analgetic activity and physical dependence liability has been achieved in animal species. By providing an open-ended, completely user-defined format, a simple means to match character strings and retrieve data records, and a convenient entree to the batch computation stream, wylbur appears to be a relatively inexpensive and useful data management tool to study chemical compounds and their biological effects.
N1  - Accession Number: ISTA0600774; Jacobson, Arthur E 1; Kaufmann, S Joel; Raub, William F; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland;  Source Info: November 1970, Vol. 10 Issue 4, p248; Note: Update Code: 0600; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T.;
AU  - Serpick, A. A.;
AU  - Carbone, P. P.;
T1  - Combination chemotherapy in the treatment of advanced Hodgkin's disease
CT  - Combination chemotherapy in the treatment of advanced Hodgkin's disease
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/12/01/
VL  - 73
IS  - Dec
SP  - 881
EP  - 895
SN  - 00034819
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, Building 10 Room 12N226, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-1008; Language: English; Chemical Name: Vincristine--57-22-7 Cyclophosphamide--6055-19-2 Procarbazine--671-16-9 Prednisone--53-03-2; References: 48; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Forty-three patients with advanced, primarily untreated Hodgkin's disease were treated with a combination of vincristine sulfate, nitrogen mustard (or cyclophosphamide), procarbazine hydrochloride, and prednisone, given in cyclical fashion for 6 months. The limiting toxicity was primarily bone marrow suppression and, although occasionally severe, was generally tolerable. Other toxicity such as alopecia and neurotoxicity were troublesome but reversible. The response rate was superior to that previously reported with the use of single drugs with 35 of 43, or 81% of the patients achieving a complete remission, defined as the complete disappearance of all tumor and return to normal performance status. The duration of these responses after all therapy was discontinued was gratifyingly long. It appears that combinations of effective drugs that act by different mechanisms and manifest different toxicities can be used effectively to increase the response rate and probably the survival of patients with sensitive tumors such as Hodgkin's disease.
KW  - Vincristine--Hodgkin's disease-;
KW  - Cyclophosphamide--Hodgkin's disease-;
KW  - Procarbazine--Hodgkin's disease-;
KW  - Prednisone--Hodgkin's disease-;
KW  - Antineoplastic agents--Hodgkin's disease--combined therapy;
KW  - Toxicity--vincristine--Hodgkin's disease, combined therapy;
KW  - Toxicity--cyclophosphamide--Hodgkin's disease, combined therapy;
KW  - Toxicity--procarbazine--Hodgkin's disease, combined therapy;
KW  - Toxicity--prednisone--Hodgkin's disease, combined therapy;
KW  - Combined therapy--Hodgkin's disease--use of vincristine, cyclophosphamide, procarbazine, and prednisone;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carbone, P. P.;
AU  - Frost, J. K.;
AU  - Feinstein, A. R.;
AU  - Higgins, G. A.;
AU  - Selawry, O. S.;
T1  - Lung cancer: perspectives and prospects
CT  - Lung cancer: perspectives and prospects
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1970/12/01/
VL  - 73
IS  - Dec
SP  - 1003
EP  - 1024
SN  - 00034819
AD  - National Cancer Institute, Building 10, Room 2-B-46, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-0877; Language: English; References: 161; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology; Abstract Author: Judith A. Kepler
N2  - In this review, studies on the adjunctive treatment of lung cancer with antineoplastic agents are summarized.
KW  - Antineoplastic agents--lung cancer--therapy, discussion of various drugs used;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lowenbraun, S.;
AU  - DeVita, V. T.;
AU  - Serpick, A. A.;
T1  - Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with Hodgkin's disease
CT  - Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with Hodgkin's disease
JO  - Blood
JF  - Blood
Y1  - 1970/12/01/
VL  - 36
IS  - Dec
SP  - 704
EP  - 716
AD  - Medical Service, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1  - Accession Number: 8-1220; Language: English; Trade Name: Nitrogen Mustard; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Procarbazine--671-16-9 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents procarbazine (68:04); AHFS Class: Steroids, cortico- prednisone; References: 30; Journal Coden: BLOOAW; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - This article describes the use of a 4-drug regimen in the treatment of advanced Hodgkin's disease. Cyclic combination therapy with mechlorethamine, vincristine, procarbazine, and prednisone was used. Nineteen of the 27 patients had a complete response, and 4 more had partial responses. Fourteen of the 19 who responded completely are still in unmaintained remission 1-24 months from completion of therapy.
KW  - Mechlorethamine--Hodgkin's disease-;
KW  - Vincristine--Hodgkin's disease-;
KW  - Procarbazine--Hodgkin's disease-;
KW  - Prednisone--Hodgkin's disease-;
KW  - Antineoplastic agents--Hodgkin's disease--combined therapy, cyclic, with mechlorethamine, vincristine, procarbazine and prednisone;
KW  - Combined therapy--Hodgkin's disease--cyclic, with mechlorethamine, vincristine, procarbazine, and prednisone;
KW  - Antineoplastic agents--mechlorethamine--combined therapy, cyclic, with vincristine, procarbazine, and prednisone, Hodgkin's disease;
KW  - Antineoplastic agents--vincristine--combined therapy, cyclic, with mechlorethamine, procarbazine, and prednisone, Hodgkin's disease;
KW  - Antineoplastic agents--procarbazine--combined therapy, cyclic, with mechlorethamine, vincristine, and prednisone, Hodgkin's disease;
KW  - Steroids, cortico---prednisone--combined therapy, cyclic, with mechlorethamine, vincristine, and procarbazine, Hodgkin's disease;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Frank, M. M.
AU  - Gaither, Thelma
T1  - The Effect of Temperature on the Reactivity of Guinea-Pig Complement with γG and γM Haemolytic Antibodies.
JO  - Immunology
JF  - Immunology
Y1  - 1970/12//
VL  - 19
IS  - 6
M3  - Article
SP  - 967
EP  - 974
SN  - 00192805
AB  - Presents a study to define quantitatively the steps in the complement sequence where gammaG and gammaM antibodies differ in their interaction with complement component , with an ultimate goal of establishing more useful complement fixation tests. Determination of whether gammaM and gammaG antobodies differ in the mechanism by which they interact with complement components after the intitiation of complement fixation; Differences which exist between the activities gammaM and gammaG hemolysins at four degrees; Persistence of the difference e in the reactions in the sites SAC1, SAC14, SAC142 and SAC1423.
KW  - IMMUNOGLOBULINS
KW  - HEMOLYSIS & hemolysins
KW  - BLOOD
KW  - IMMUNITY
KW  - ANTIGEN-antibody reactions
KW  - SERUM
KW  - GLOBULINS
N1  - Accession Number: 14528311; Frank, M. M. 1; Gaither, Thelma 1; Source Information: Dec70, Vol. 19 Issue 6, p967; Subject: IMMUNOGLOBULINS; Subject: HEMOLYSIS & hemolysins; Subject: BLOOD; Subject: IMMUNITY; Subject: ANTIGEN-antibody reactions; Subject: SERUM; Subject: GLOBULINS; Number of Pages: 8p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Frank, M. M.
AU  - Gaither, Thelma
T1  - Evidence that Rabbit γG Haemolysin is Capable of Utilizing Guinea-Pig Complement More Efficiently than Rabbit γM Haemolysin.
JO  - Immunology
JF  - Immunology
Y1  - 1970/12//
VL  - 19
IS  - 6
M3  - Article
SP  - 975
EP  - 981
SN  - 00192805
AB  - Sheep erythrocytes sensitized with rabbit γG anti-Forssman haemolysin may be haemolysed more efficiently and to a greater extent by limited amounts of guinea-pig complement components than are cells sensitized with γM anti-Forssman haemolysin. This apparent difference, noted in all components titrations, was two-fold or greater in titrations of C2 and components following C2 in the haemolytic sequence. Neither site to site transfer of C2 nor AC 142 could account for the 100 per cent greater haemolytic efficiency of C2 in haemolytic assays. These results indicate that immunoglobulin class plays a more complex role in immune haemolysis than simple initiation of complement fixation and suggest that γG complement fixing sites may be more efficient than γM sites in producing biological damage. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ERYTHROCYTES
KW  - BLOOD cells
KW  - HEMOLYSIS & hemolysins
KW  - IMMUNITY
KW  - BLOOD
KW  - ANTIGEN-antibody reactions
N1  - Accession Number: 14528338; Frank, M. M. 1; Gaither, Thelma 1; Source Information: Dec70, Vol. 19 Issue 6, p975; Subject: ERYTHROCYTES; Subject: BLOOD cells; Subject: HEMOLYSIS & hemolysins; Subject: IMMUNITY; Subject: BLOOD; Subject: ANTIGEN-antibody reactions; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dresback, D. S.;
AU  - Gallelli, J. F.;
T1  - Quantitative analysis and stability of 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide in acidic aqueous solutions
CT  - Quantitative analysis and stability of 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide in acidic aqueous solutions
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1970/12/01/
VL  - 59
IS  - Dec
SP  - 1829
EP  - 1833
SN  - 00223549
AD  - Pharmaceutical Development Service, Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-2303; Language: English; Trade Name: NSC-82196; Generic Name: Carboxamide; References: 6; Journal Coden: JPMSAE; Section Heading: Drug Stability; Preliminary Drug Testing
N2  - Methods of quantitative analysis by UV spectrophotometric, colorimetric, and ionic chloride determination are reported for 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196), a promising antileukemic agent, in the presence of its degradation products. With the exception of the ionic chloride method of analysis of samples exposed to light, all 3 methods showed good agreement for stability studies of NSC-82196 in acidic aqueous solutions exposed to light and dark and stored at 25\DG/. A sterile lyophilized hydrochloride salt of NSC-82196 for parenteral use, reconstituted with water for injection, was found to have a t\IF/1/2 \BS/= 150 minutes at 25\DG/ and t\IF/1/2 \BS/= 65 hours at 4\DG/. Graphs and tables are included.
KW  - Carboxamide--5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)--;
KW  - Stability--carboxamide--5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-, in acidic aqueous solutions;
KW  - Analysis--carboxamide--5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-, quantitative, and stability, in acidic aqueous solutions;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Parry, Hugh J.
AU  - Balter, Mitchell B.
AU  - Cisin, Ira H.
T1  - PRIMARY LEVELS OF UNDERREPORTING PSYCHOTROPIC DRUG USE.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1970///Winter70-Winter71
VL  - 34
IS  - 4
M3  - Article
SP  - 582
EP  - 592
PB  - Oxford University Press / USA
SN  - 0033362X
AB  - The present article reports on a methodological problem: The extent to which use of psychotropes is underreported by various population subgroups and under various techniques of questioning. Comparative findings for antibiotic use are also reported. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Psychiatric drugs
KW  - Drug abuse
KW  - Antibiotics
KW  - Psychopharmacology
KW  - Behavioral toxicology
N1  - Accession Number: 5414842; Parry, Hugh J. 1; Balter, Mitchell B. 2; Cisin, Ira H. 3,4; Affiliations: 1: Associate Director, Social Research Group, George Washington University, Washington D.C.; 2: Chief of the Special Studies Section, Psychopharmacology Research Branch of the National Institute of Mental Health; 3: Director of the Social Research Group, George Washington University; 4: Professor of Sociology, George Washington University; Issue Info: Winter70-Winter71, Vol. 34 Issue 4, p582; Subject Term: Psychiatric drugs; Subject Term: Drug abuse; Subject Term: Antibiotics; Subject Term: Psychopharmacology; Subject Term: Behavioral toxicology; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
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DB  - ufh
ER  - 

TY  - JOUR
AU  - Frandsen, Asger M.
AU  - Barbano, Joseph P.
AU  - Suomi, John D.
AU  - Chang, Jacqueline J.
AU  - Burke, Allyn D.
T1  - The effectiveness of the Charters', scrub and roll methods of toothbrushing by professionals in removing plaque.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1970/12//
VL  - 78
IS  - 7
M3  - Article
SP  - 459
EP  - 463
SN  - 0029845X
AB  - The effectiveness of the <em>Charters'</em>, scrub, and roll methods of toothbrushing by professional dental personnel in removing plaque was studied in 60 United States Army recruits. An interaction between method of brushing and brusher was found, indicating that no one method was clearly most effective in removing plaque. One brusher removed significantly more plaque with the <em>Charters'</em> method than with the roll method, whereas the other brusher obtained a significantly greater reduction in plaque with the scrub method than with either the <em>Charters'</em> or the roll methods. [ABSTRACT FROM AUTHOR]
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KW  - DENTAL plaque
KW  - DENTAL deposits
KW  - DENTAL personnel -- United States
KW  - MEDICAL personnel
KW  - UNITED States
N1  - Accession Number: 16615062; Frandsen, Asger M. 1; Barbano, Joseph P. 2; Suomi, John D. 2; Chang, Jacqueline J. 2; Burke, Allyn D. 3; Source Information: 1970, Vol. 78 Issue 7, p459; Subject: DENTAL plaque; Subject: DENTAL deposits; Subject: DENTAL personnel -- United States; Subject: MEDICAL personnel; Geographic Terms: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - HOOD, LEROY E.
AU  - POTTER, MICHAEL
AU  - MCKEAN, DAVID J.
T1  - Immunoglobulin Structure: Amino Terminal Sequences of Kappa Chains from Genetically Similar Mice (BALB/c).
JO  - Science
JF  - Science
Y1  - 1970/12/11/
VL  - 170
IS  - 3963
M3  - Article
SP  - 1207
EP  - 1210
SN  - 00368075
AB  - The amino terminal portion of 20 kappa chains from the highly inbred BALB/c mouse has been examined on an automatic protein sequencer. These proteins can be divided into at least nine groups (subgroups) based on sequence patterns which are so distinct that each subgroup is probably encoded by at least one germ-line gene. The subgroups of mouse kappa chains are generally quite different from those of human kappa chains. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438544; HOOD, LEROY E. 1; POTTER, MICHAEL 1; MCKEAN, DAVID J. 2; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Biology Department, Johns Hopkins University, Baltimore, Maryland; Issue Info: 12/11/1970, Vol. 170 Issue 3963, p1207; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ZBAR, BERTON
AU  - BERNSTEIN, IRWIN
AU  - TANAKA, TOMIKO
AU  - RAPP, HERBERT J.
T1  - Tumor Immunity Produced by the Intradermal Inoculation of Living Tumor Cells and Living Mycobacterium bovis (Strain BCG).
JO  - Science
JF  - Science
Y1  - 1970/12/11/
VL  - 170
IS  - 3963
M3  - Article
SP  - 1217
EP  - 1218
SN  - 00368075
AB  - The intradermal inoculation of mixtures containing living tumor cells and living Mycobacterium bovis (strain BCG) into unimmunized syngeneic guinea pigs results in an inflammatory reaction to the BCG, and there is no progressive tumor growth. In the absence of BCG the tumor grows progressively, metastasizes, and kills the animal. By conventional methods, it has not been possible to immunize syngeneic guinea pigs to the tumor used. Guinea pigs that receive mixtures of BCG and tumor cells, however, develop specific systemic tumor immunity as measured by delayed cutaneous hypersensitivity and by suppression of tumor growth. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438549; ZBAR, BERTON 1; BERNSTEIN, IRWIN 1; TANAKA, TOMIKO 1; RAPP, HERBERT J. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/11/1970, Vol. 170 Issue 3963, p1217; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WOOD, WILLIAM C.
AU  - MORTON, DONALD L.
T1  - Microcytotoxicity Test: Detection in Sarcoma Patients of Antibody Cytotoxic to Human Sarcoma Cells.
JO  - Science
JF  - Science
Y1  - 1970/12/18/
VL  - 170
IS  - 3964
M3  - Article
SP  - 1318
EP  - 1320
SN  - 00368075
AB  - A microcytotoxicity test has been used to detect a factor cytotoxic for human sarcoma cells; the factor was found in serums from 70 percent of sarcoma patients, 58 percent of their family members, and 8 percent of serums from normal blood donors. This cytotoxin is an antibody against a common cell surface sarcoma antigen since it is specific for sarcoma cells, is complement dependent, and is extractable with the globulin fraction of serum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87924152; WOOD, WILLIAM C. 1; MORTON, DONALD L. 1; Affiliations: 1: Tumor Immunology Section, Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1318; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LEMBERGER, LOUIS
AU  - SILBERSTEIN, STEPHEN D.
AU  - AXELROD, JULIUS
AU  - KOPIN, IRWIN J.
T1  - Marihuana: Studies on the Disposition and Metabolism of Delta-9-Tetrahydrocannabinol in Man.
JO  - Science
JF  - Science
Y1  - 1970/12/18/
VL  - 170
IS  - 3964
M3  - Article
SP  - 1320
EP  - 1322
SN  - 00368075
AB  - Δ9-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t1/2 = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Δ9-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87924153; LEMBERGER, LOUIS 1; SILBERSTEIN, STEPHEN D. 1; AXELROD, JULIUS 1; KOPIN, IRWIN J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1320; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - COHN, CAL K.
AU  - DUNNER, DAVID L.
AU  - AXELROD, JULIUS
T1  - Reduced Catechol-O-Methyltransferase Activity in Red Blood Cells of Women with Primary Affective Disorder.
JO  - Science
JF  - Science
Y1  - 1970/12/18/
VL  - 170
IS  - 3964
M3  - Article
SP  - 1323
EP  - 1324
SN  - 00368075
AB  - Red blood cell catechol-O-methyltransferase, histamine-N-methyltransferase, and a methanol-forming enzyme were examined in a number of subjects with mental diseases. Catechol-O-methyltransferase activity was significantly reduced in female subjects with primary affective disorder (depression) as compared to normal women and men, men with primary affective disorder, and schizophrenic men and women. In depressed women, histamine-N-methyltransferase activity was elevated and the methanol-forming enzyme was unchanged. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87924154; COHN, CAL K. 1; DUNNER, DAVID L. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1323; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MANO, NORI-ICHI
T1  - Changes of Simple and Complex Spike Activity of Cerebellar Purkinje Cells with Sleep and Waking.
JO  - Science
JF  - Science
Y1  - 1970/12/18/
VL  - 170
IS  - 3964
M3  - Article
SP  - 1325
EP  - 1327
SN  - 00368075
AB  - Action potentials of cerebellar Purkinje cells were observed in intact monkeys during sleep and waking. Purkinje cells exhibit two sorts of action potentials, called simple and complex spikes, and these two sorts of spikes were differently affected by sleep. Simple-spike activity (generated by the parallel fiber inputs to the Purkinje cell) was highest during sleep with rapid eye movements as compared with both waking and sleep with electroencephalographic slow waves. In contrast, complex-spike activity (generated by the climbing fiber inputs to the Purkinje cell) was lowest during sleep with rapid eye movements. The complex action potential of the Purkinje cell consists of an initial large spike followed by one or more smaller secondary spikes, and the number of these secondary spikes was found to be independent of the background discharge frequency of the simple spike. This independence suggests a possible role of presynaptic factors rather than the excitability level of the Purkinje cell itself in determining the number of secondary discharges occurring in the complex spike. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87924155; MANO, NORI-ICHI 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1325; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Urokinase Pulmonary Embolism Trial Study Group;
T1  - Urokinase Pulmonary Embolism Trial. Phase 1 results. A cooperative study
CT  - Urokinase Pulmonary Embolism Trial. Phase 1 results. A cooperative study
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1970/12/21/
VL  - 214
IS  - Dec 21
SP  - 2163
EP  - 2172
AD  - Dr. J. M. Stengle, National Heart and Lung Institute, National Institutes of Health, 4A-03 Bldg. 31, Bethesda, Maryland 20014
N1  - Accession Number: 8-2463; Language: English; Chemical Name: Urokinase--9039-53-6 Heparin--9005-49-6; Therapeutic Class: (20:12.04); AHFS Class: Anticoagulants heparin (44:00); AHFS Class: Enzymes urokinase; References: 20; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - In a randomized, national cooperative trial, urokinase and subsequent heparin sodium therapy, when compared to heparin therapy alone, significantly accelerated the resolution rate of pulmonary thromboemboli at 24 hours as shown by pulmonary arteriograms, lung scans, and right-sided pressure measurements. No significant differences in recurrence rate of pulmonary embolism or in the 2-week mortality were observed. Bleeding, which occurred in 45% of patients receiving urokinase as contrasted to 27% in the heparin group, was the only complication of urokinase therapy. This increase in bleeding seen with urokinase was closely associated with the invasive procedures necessary to obtain the arteriographic and hemodynamic information. Because the urokinase regimen did not usually achieve complete or nearly complete thrombolysis, and because of its hemorrhagic property, further studies with urokinase in pulmonary thromboembolism are indicated before specific therapeutic recommendations can be made.
KW  - Urokinase--and subsequent heparin-;
KW  - Heparin--alone and subsequent to urokinase-;
KW  - Anticoagulants--heparin--alone and subsequent to urokinase, in Urokinase Pulmonary Embolism Trial;
KW  - Enzymes--urokinase--and subsequent heparin, in Urokinase Pulmonary Embolism Trial, comparison with heparin alone;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bunney, W. E.;
AU  - Brodie, H. K. H.;
AU  - Murphy, D. L.;
AU  - Goodwin, F. K.;
T1  - Studies of alpha-methyl-para-tyrosine, L-dopa and L-tryptophan in depression and mania
CT  - Studies of alpha-methyl-para-tyrosine, L-dopa and L-tryptophan in depression and mania
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1971/01/01/
VL  - 127
IS  - Jan
SP  - 872
EP  - 881
SN  - 0002953X
AD  - National Institute of Mental Health, Laboratory of Clinical Science, Section of Psychiatry, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 9-0764; Language: English; Chemical Name: Levodopa--59-92-7 Tryptophan--73-22-3 \a/-Methyl-p-tyrosine--658-48-0; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants levodopa (28:16.04); AHFS Class: Antidepressants tryptophan (28:16.04); AHFS Class: Antidepressants \a/-methyl-p-tyrosine; References: 52; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - L-Dopa (levodopa), L-tryptophan and alpha-methyl-para-tyrosine (I) were administered to depressed and manic patients in an attempt to decrease their psychopathology and to test the monoamine theory of affective disorders. The drugs were administed in a double-blind nonrandom procedure. The average duration of administration and average maximum dose of the compounds were: alpha-methyl-para-tyrosine 3 g. for 15 days, levodopa 7 g. for 30 days and tryptophan 8 g. for 16 days. L-dopa and I clearly altered mood and thought patterns in some patients, while L-tryptophan was less active. Analysis of urinary and cerebrospinal fluid amine metabolites documented the metabolic effects of the compounds during periods of behavioral changes.
KW  - Levodopa--effects-;
KW  - Tryptophan--effects-;
KW  - \a/-Methyl-p-tyrosine--effects-;
KW  - Antidepressants--levodopa--effects, in depression and mania, in patients;
KW  - Antidepressants--tryptophan--effects, in depression and mania, in patients;
KW  - Antidepressants--\a/-methyl-p-tyrosine--effects, in depression and mania, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Markley, K.;
T1  - Vaccine prophylaxis for pseudomonas infections
CT  - Vaccine prophylaxis for pseudomonas infections
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/01/01/
VL  - 74
IS  - Jan
SP  - 140
SN  - 00034819
AD  - Laboratory of Biochemical Pharmacology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-1543; Language: English; References: 15; Publication Type: Editorial Notes; Journal Coden: AIMEAS; Section Heading: Microbiology; Investigational Drugs; Abstract Author: Judith A. Kepler
N2  - The development of an effective pseudomonas vaccine for the prophylaxis of fatal pseudomonas infection in burned patients has been reported. The advent of vaccine and immune globulin for pseudomonas infections adds another dimension to current therapy, which includes topical and systemic antibiotics against pseudomonas, gamma globulin, and control of the bacterial environment of the patient. Although effective control of infection by pseudomonas is now possible, however, the intrinsic susceptibility of the patients often leads to infection by other organisms.
KW  - Vaccines--pseudomonas--prophylaxis in burned patients;
KW  - Infections--pseudomonas--prophylaxis, vaccine, in burned patients;
KW  - Drugs--clinical effectiveness--pseudomonas vaccine, prophylaxis in burned patients;
KW  - Pseudomonas aeruginosa--vaccines--prophylaxis, in burned patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Hodes, Louis
T1  - Solving problems by formula manipulation in logic and linear inequalities
JO  - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 553-559. 1 Tab. 9 Ref. See Isa 72-005/y
JF  - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 553-559. 1 Tab. 9 Ref. See Isa 72-005/y
Y1  - 1971///
M3  - Book
N1  - Accession Number: ISTA0700327; Hodes, Louis 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1971; Note: Update Code: 0700; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Lee, Richard C T
T1  - Fuzzy logic and the resolution principle
JO  - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 560-567. 1 Illus. 27 Ref. See Isa 72-005/y
JF  - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 560-567. 1 Illus. 27 Ref. See Isa 72-005/y
Y1  - 1971///
M3  - Book
AB  - Problem-solving systems using two-valued logic suffer from one drawback; they cannot handle fuzzy, or uncertain, information. In this paper, the author recommends the use of fuzzy logic, which is based on the concept of fuzzy sets and first order predicate calculus. It is proved that, in fuzzy logic, a set of clauses is unsatisfiable if it is unsatisfiable in two-valued logic. It is also shown that if the most unreliable clause of a set of clauses has a truth-value a>0.5, then all the logical consequences obtained by repeatedly applying the resolution principle has truth-value never smaller than a. Implications of these results for applying fuzzy logic to problem-solving are discussed
N1  - Accession Number: ISTA0700329; Lee, Richard C T 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1971; Note: Update Code: 0700; Document Type: Book
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DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hartwell, J. L.;
T1  - Plants used against cancer. A survey (continued)
CT  - Plants used against cancer. A survey (continued)
JO  - Lloydia
JF  - Lloydia
Y1  - 1971/01/01/
VL  - 34
IS  - Jan
SP  - 103
EP  - 160
AD  - National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 9-0269; Language: English; Journal Coden: LLOYA2; Section Heading: Pharmacognosy; Pharmacology; Abstract Author: M. A. Iyengar
N2  - In a continuing article, a record of several plants from 12 families along with their references embracing the history of medicine, pharmacology, materia medica, medical botany, ethnobotany and folklore has been presented here. Both technical literature and folklore could be sources of information on use of plants for the treatment of cancer and other growths, and thus these records might be useful in providing leads for the laboratory investigation of other plants and the development of useful drugs in the therapy of human cancer. This comprehensive survey consists of both published literature and unpublished data. The 12 different families appearing in this article are: Primulaceae, Proteaceae, Punicaceae, Pyrolaceae, Rafflesiaceae, Ranunculaceae, Resedaceae, Rhamnaceae, Rhizophoraceae, Rosaceae, Rubiaceae and Rutaceae.
KW  - Rhizophoraceae--antineoplastic agents--survey;
KW  - Rosaceae--antineoplastic agents--survey;
KW  - Rubiaceae--antineoplastic agents--survey;
KW  - Rutaceae--antineoplastic agents;
KW  - History--plants agents--survey survey of 12 different families with reference to antineoplastic effects;
KW  - Antineoplastic agents--plants--survey, 12 families;
KW  - Plants--antineoplastic agents--survey, of 12 families;
KW  - Primulaceae--antineoplastic agents--survey;
KW  - Proteaceae--antineoplastic agents--survey;
KW  - Punicaceae--antineoplastic agents--survey;
KW  - Pyrolaceae--antineoplastic agents--survey;
KW  - Rafflesiaceae--antineoplastic agents--survey;
KW  - Ranunculaceae--antineoplastic agents--survey;
KW  - Resedaceae--antineoplastic agents--survey;
KW  - Rhamnaceae--antineoplastic agents--survey;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - Selective dissemination and indexing of scientific information
JO  - Science 173(3994), 300-308 (1971 July 23). 52 Ref
JF  - Science 173(3994), 300-308 (1971 July 23). 52 Ref
Y1  - 1971///
M3  - Book Chapter
AB  - Some basic aspects of sdi (selective dissemination of information) systems are presented, and recent developments and problems are described. Two different approaches to indexing information for sdi are discussed, emphasizing the desirability of using enumerative hierarchical classifications to improve the precision and quality of matching scientists with useful documents.
N1  - Accession Number: ISTA0700189; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland.;  Source Info: 1971; Note: Update Code: 0700; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - MOHIT, BEHZAD
AU  - KANG FAN
T1  - Hybrid Cell Line from a Cloned Immunoglobulin-Producing Mouse Myeloma and a Nonproducing Mouse Lymphoma.
JO  - Science
JF  - Science
Y1  - 1971/01/08/
VL  - 171
IS  - 3966
M3  - Article
SP  - 75
EP  - 77
SN  - 00368075
AB  - A hybrid cell line was established by cell fusion between a cloned Balbic myeloma that is resistant to 8-azaguanine and produces immunoglobulin (yG and free kappa chain) and C57BL/6N lymphoma that is resistant to bromodeoxyuridine and does not produce immunoglobulins. The hybrid cells contained the membrane antigens of both parents; they synthesized free kappa chain; no synthesis of γG (γ2a) heavy chain was detected. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104232; MOHIT, BEHZAD 1; KANG FAN 1; Affiliations: 1: Cell Chemistry Laboratory, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethescla, Maryland 20014; Issue Info: 1/ 8/1971, Vol. 171 Issue 3966, p75; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WURTZ, ROBERT H.
AU  - GOLDBERG, MICHAEL E.
T1  - Superior Coiliculus Cell Responses Related to Eye Movements in Awake Monkeys.
JO  - Science
JF  - Science
Y1  - 1971/01/08/
VL  - 171
IS  - 3966
M3  - Article
SP  - 82
EP  - 84
SN  - 00368075
AB  - Single cell responses were recorded from the superior colliculus of awake monkeys trained to move their eyes. A class of cells that discharged before eye movements was found in the intermediate and deep layers of the colliculus. The response of the cells was most vigorous before saccadic eye movements within a particular range of directions. These cells had no visual receptive fields, and visually guided eye movements were not necessary for their discharge, since they responded in total darkness before spontaneous eye movements and vestibular nystagmus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104235; WURTZ, ROBERT H. 1; GOLDBERG, MICHAEL E. 1; Affiliations: 1: Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/ 8/1971, Vol. 171 Issue 3966, p82; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WILSON, W. E.
AU  - FISHBEIN, L.
AU  - CLEMENTS, S. T.
T1  - DDT: Participation in Ultraviolet-Detectable, Charge-Transfer Complexation.
JO  - Science
JF  - Science
Y1  - 1971/01/15/
VL  - 171
IS  - 3967
M3  - Article
SP  - 180
EP  - 182
SN  - 00368075
AB  - The chlorophenyl groups of DDT and several of its metabolites are capable of participating in a charge-transfer interaction with tetracyanoethylene detectable in the ultraviolet region of the spectrum. In addition, during a change of state DDT undergoes ultraviolet spectral alterations that closely resemble those previously claimed to support the hypothesis suggesting charge-transfer interaction between this pesticide and a component of insect nerve tissue. The pesticide DDT possesses structural characteristics that would permit it to participate in several types of molecular association. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438495; WILSON, W. E. 1; FISHBEIN, L. 1; CLEMENTS, S. T. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p180; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SIGGINS, G. R.
AU  - OLIVER, A. P.
AU  - HOFFER, B. J.
AU  - BLOOM, F. E.
T1  - Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells.
JO  - Science
JF  - Science
Y1  - 1971/01/15/
VL  - 171
IS  - 3967
M3  - Article
SP  - 192
EP  - 194
SN  - 00368075
AB  - Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438500; SIGGINS, G. R. 1; OLIVER, A. P. 1; HOFFER, B. J. 1; BLOOM, F. E. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p192; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - CRAYTON, JOHN W.
AU  - NICOLL, ROGER A.
T1  - Supraoptic Neurosecretory Cells: Autonomic Modulation.
JO  - Science
JF  - Science
Y1  - 1971/01/15/
VL  - 171
IS  - 3967
M3  - Article
SP  - 206
EP  - 207
SN  - 00368075
AB  - Neurosecretory cells in the supraoptic nuclei of anesthetized cats were antidromically identified by electrical stimulation of the posterior pituitary. The responses of these units to afferent volleys from vagal and carotid sinus nerves were examined with a computer of average transients. Synaptic excitation of neurosecretory cells by stimulation of these pathways demonstrates the existence of excitatory inputs from vagal and carotid sinus nerve afferents. Since these pathways are involved in the release of antidiuretic hormone, the results support the hypothesis that its release is related to an increase in discharge frequency of supraoptic neurosecretory cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438507; BARKER, JEFFERY L. 1; CRAYTON, JOHN W. 1; NICOLL, ROGER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p206; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - CRAYTON, JOHN W.
AU  - NICOLL, ROGER A.
T1  - Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity.
JO  - Science
JF  - Science
Y1  - 1971/01/15/
VL  - 171
IS  - 3967
M3  - Article
SP  - 207
EP  - 210
SN  - 00368075
AB  - Adrenergic and cholinergic agonists and antagonists were applied microelectrophoretically to over 700 neurons in the cat supraoptic nucleus, 20 percent of which were antidromically identified as neurosecretory cells. Norepinephrine uniformly depressed all sensitive cells. Acetylcholine caused both muscarinic depression and nicotinic excitation which were antagonized by atropine and dihydro-β-erythroidine, respectively. These results support the hypothesis that norepinephrine and acetylcholine release of antidiuretic hormone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438508; BARKER, JEFFERY L. 1; CRAYTON, JOHN W. 1; NICOLL, ROGER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p207; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NAHMIAS, A. J.
AU  - LONDON, W. T.
AU  - CATALANO, L. W.
AU  - FUCCILLO, D. A.
AU  - SEVER, J. L.
AU  - GRAHAM, C.
T1  - Genital Herpesvirus Hominis Type 2 Infection: An Experimental Model in Cebus Monkeys.
JO  - Science
JF  - Science
Y1  - 1971/01/22/
VL  - 171
IS  - 3968
M3  - Article
SP  - 297
EP  - 298
SN  - 00368075
AB  - Genital infection with herpesvirus hominis type 2 was established in ten female cebus monkeys. Clinical and laboratory findings in the cebus mimic closely those observed in humans, thus providing an experimental model which may be used in the study of the possible role of genital herpetic infection in cervical cancer and in perinatal and chronic neurological diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Capuchin monkeys
KW  - Herpesvirus diseases in animals
KW  - DISEASES
KW  - Animal models in research
KW  - Herpes simplex virus
KW  - Genitalia
KW  - Herpes genitalis
KW  - Cervical cancer -- Risk factors
KW  - Nervous system
KW  - RISK factors
N1  - Accession Number: 85104275; NAHMIAS, A. J. 1; LONDON, W. T.; CATALANO, L. W.; FUCCILLO, D. A.; SEVER, J. L. 2; GRAHAM, C. 3; Affiliations: 1: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303; 2: Perinatal Research Branch, National Institutes of Health, Bethesda, Maryland; 3: Yerkes Primate Research Center, Emory University, Atlanta; Issue Info: 1/22/1971, Vol. 171 Issue 3968, p297; Thesaurus Term: Capuchin monkeys; Thesaurus Term: Herpesvirus diseases in animals; Thesaurus Term: DISEASES; Thesaurus Term: Animal models in research; Subject Term: Herpes simplex virus; Subject Term: Genitalia; Subject Term: Herpes genitalis; Subject Term: Cervical cancer -- Risk factors; Subject Term: Nervous system; Subject Term: RISK factors; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 
TY  - JOUR
AU  - PAUL, MICHAEL I.
AU  - CRAMER, HINRICH
AU  - BUNNEY JR., WILLIAM E.
T1  - Urinary Adenosine 3',5'-Monophosphate in the Switch Process from Depression to Mania.
JO  - Science
JF  - Science
Y1  - 1971/01/22/
VL  - 171
IS  - 3968
M3  - Article
SP  - 300
EP  - 303
SN  - 00368075
AB  - Marked elevations of urinary adenosine 3',5'-monophosphate occurred on the day of rapid switch from a depressed into a manic state in patients' with manic-depressive illness. It is suggested that this increase might serve a trigger function for the process by which catecholamines are elevated during the manic phase of the illness. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bipolar disorder
KW  - Urinalysis
KW  - Cyclic adenylic acid
KW  - Catecholamines
KW  - Mania
KW  - Mental depression
N1  - Accession Number: 85104277; PAUL, MICHAEL I. 1; CRAMER, HINRICH 2; BUNNEY JR., WILLIAM E. 3; Affiliations: 1: Neuropsychiatric Institute, Ceiter for the Health Sciences, University of California, Los Anugeles 90024; 2: Laboratory of Chelinical Pharmacology, National Heart and Lung Institute, Bethesa, Maryland 20014; 3: Laboratory of Clinical Scienice, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/22/1971, Vol. 171 Issue 3968, p300; Subject Term: Bipolar disorder; Subject Term: Urinalysis; Subject Term: Cyclic adenylic acid; Subject Term: Catecholamines; Subject Term: Mania; Subject Term: Mental depression; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Meyer, H. M.;
AU  - Parkman, P. D.;
T1  - Rubella vaccination. A review of practical experience
CT  - Rubella vaccination. A review of practical experience
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1971/01/25/
VL  - 215
IS  - Jan 25
SP  - 613
EP  - 619
AD  - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-2314; Language: English; References: 36; Journal Coden: JAMAAP; Section Heading: Pharmacology; Abstract Author: Dale E. Johnson
N2  - Rubella virus vaccine became commercially available in the United States on June 10, 1969, and by October 1, 1970, approximately 28 million doses had been distributed for domestic use. The earlier experimental data pertaining to vaccine safety have been supported by the larger experience since licensure. Troublesome reactions clearly associated with immunization have largely been confined to rubella-like symptoms of joint pain and related complaints. There is no evidence that community-wide vaccine use has posed a significant risk of attenuated virus transmission to contacts. The greatest preventable problem attending immunization has been the inadvertent inoculation of pregnant women. New studies have furnished additional information concerning the quality and durability of vaccine-induced immunity. There has been some disagreement among scientists in the interpretation of these and other data bearing on the national immunization program. The authors are of the opinion that the present recommendations for vaccine use are sound and represent the best of the options currently available for preventing maternal-fetal rubella in the United States.
KW  - Rubella vaccines--virus-;
KW  - Immunization--rubella--review of practical experience with rubella virus vaccine;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - FRENSDORFF, ASHER
AU  - JONES, PATRICIA P.
AU  - BERWALD-NETTER, YOHEVED
AU  - CEBRA, JOHN J.
AU  - MAGE, ROSE
T1  - Selective Stimulation of Allelic Expression: Effect of Antibodies to Allotypic Markers on Lymphoid Cells.
JO  - Science
JF  - Science
Y1  - 1971/01/29/
VL  - 171
IS  - 3969
M3  - Article
SP  - 391
EP  - 394
SN  - 00368075
AB  - Peripheral blood leukocytes from rabbits which were heterozygous (b5/b9) for markers on their immunoglobulin light chains were maintained in vitro for up to 24 hours in the presence or absence of antibody to b9. After culture they were transferred into lethally irradiated b4/b4 hosts. Recipients of cells exposed to antibodies to allotype markers showed a striking increase in concentration of circulating b9 molecules and number of b9 plasma cells in their spleens compared to control animals receiving untreated cells from the same donor. There was no appreciable difyerence between the two groups of recipients with respect to their content of b5 molecules and immunocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104317; FRENSDORFF, ASHER 1; JONES, PATRICIA P. 1; BERWALD-NETTER, YOHEVED 1; CEBRA, JOHN J. 1; MAGE, ROSE 2; Affiliations: 1: Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218; 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 1/29/1971, Vol. 171 Issue 3969, p391; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DAWE, C. J.
AU  - WHANG-PENG, J.
AU  - MORGAN, W. D.
AU  - HEARON, E. C.
AU  - KNUTSEN, T.
T1  - Epithelial Origin of Polyoma Salivary Tumors in Mice: Evidence Based on Chromosome-Marked Cells.
JO  - Science
JF  - Science
Y1  - 1971/01/29/
VL  - 171
IS  - 3969
M3  - Article
SP  - 394
EP  - 397
SN  - 00368075
AB  - Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T6 chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of class'ical problens concerning epithelial as opposed to mesenchymal origin of neoplasms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104318; DAWE, C. J. 1; WHANG-PENG, J. 1; MORGAN, W. D. 1; HEARON, E. C. 1; KNUTSEN, T. 1; Affiliations: 1: Laboratory of Patholooy and Human Cell Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/29/1971, Vol. 171 Issue 3969, p394; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ELLINWOOD, EVERETT H.
AU  - COHEN, SIDNEY
T1  - Amphetamine Abuse.
JO  - Science
JF  - Science
Y1  - 1971/01/29/
VL  - 171
IS  - 3969
M3  - Article
SP  - 420
EP  - 421
SN  - 00368075
N1  - Accession Number: 85104330; ELLINWOOD, EVERETT H. 1; COHEN, SIDNEY 2; Affiliations: 1: Duke University School of Medicine, Durham, North Carolina; 2: National Institute of Mental Health, Bethesda, Maryland; Issue Info: 1/29/1971, Vol. 171 Issue 3969, p420; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Crane, G. E.;
AU  - Johnson, A. W.;
AU  - Buffaloe, W. J.;
T1  - Long-term treatment with neuroleptic drugs and eye opacities
CT  - Long-term treatment with neuroleptic drugs and eye opacities
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1971/02/01/
VL  - 127
IS  - Feb
SP  - 1045
EP  - 1049
SN  - 0002953X
AD  - Spring Grove State Hospital, Catonsville, Maryland 21228
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Maryland
N1  - Accession Number: 8-1826; Language: English; Chemical Name: Chlorpromazine--50-53-3; References: 14; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity
N2  - Approximately 100 chronic schizophrenic patients were examined for drug-induced eye changes. The lens was affected in 36 patients, and the cornea in 19. There was a linear relationship between eye opacities and the total intake of drugs. Corneal opacities were also related to the intake of high doses of chlorpromazine over a short period of time. In most instances the ocular changes were irreversible. Despite heavy deposits in the anterior part of the eye, vision was unimpaired and the retina appeared to be intact.
KW  - Chlorpromazine--toxicity-;
KW  - Psychotherapeutic agents--toxicity--chronic schizophrenics examined for drug-induced eye changes;
KW  - Toxicity--psychotherapeutic agents--chronic schizophrenics examined for drug-induced eye changes;
KW  - Toxicity--chlorpromazine--corneal opacities, related to high doses;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lipsett, M. B.;
AU  - Combs, J. W., Jr.;
AU  - Catt, K.;
AU  - Seigel, D. G.;
T1  - Problems in contraception
CT  - Problems in contraception
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/02/01/
VL  - 74
IS  - Feb
SP  - 251
EP  - 263
SN  - 00034819
AD  - National Institute of Child Health and Human Development, Bldg. 10, Room 12-N-204, National Institutes of Health, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland
N1  - Accession Number: 8-1823; Language: English; References: 45; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Toxicity; Abstract Author: Judith A. Kepler
N2  - Recent trends in birth rate are evaluated and adverse effects of oral contraceptives are reviewed. A review of the processes involved in sperm and ovum maturation and fertilization shows many areas where other approaches to contraception may be fruitful.
KW  - Contraceptives--problems and new approaches--discussion;
KW  - Contraceptives, oral--adverse reactions--review;
KW  - Toxicity--contraceptives, oral--review;
KW  - Sociology--birth rate--trends, recent, discussion;
KW  - Drugs, adverse reactions--contraceptives, oral--review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Wyatt, R. J.;
AU  - Fram, D. H.;
AU  - Kupfer, D. J.;
AU  - Synder, F.;
T1  - Total prolonged drug-induced REM sleep suppression in anxious-depressed patients
CT  - Total prolonged drug-induced REM sleep suppression in anxious-depressed patients
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1971/02/01/
VL  - 24
IS  - Feb
SP  - 145
EP  - 155
AD  - Laboratory of Clinical Psychobiology, DCBR, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0829; Language: English; Trade Name: Nardil; Generic Name: Phenelzine; Chemical Name: Phenelzine--51-71-8; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants phenelzine; References: 64; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Phenelzine (Nardil) was administered to 6 nonpsychotic, anxious-depressed patients while daily behavioral and EEG sleep records were made. Total suppression of rapid eye movement (REM) sleep for from 14 to 40 nights resulted when doses up to 75 mg./day was given. When REM sleep was absent, behavior markedly improved and no morning recall of dreams occurred. Upon discontinuation of the drug, the REM sleep increased above baseline for all patients and up to 250% above normal; dreaming was also reported. Evidence from this study and others indicates that suppression of REM sleep might help to alleviate depression.
KW  - Phenelzine--effects-;
KW  - Antidepressants--phenelzine--depresses REM sleep, in depressed patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kupfer, D. J.;
AU  - Wyatt, R. J.;
AU  - Synder, F.;
AU  - Davis, J. M.;
T1  - Chlorpromazine and sleep in psychiatric patients
CT  - Chlorpromazine and sleep in psychiatric patients
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1971/02/01/
VL  - 24
IS  - Feb
SP  - 185
EP  - 189
AD  - Laboratory of Clinical Psychobiology, Division of Clinical and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 8-2479; Language: English; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; References: 19; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - Chlorpromazine was investigated in 9 patients, ranging in age from 20 to 49 years, for its effect on rapid eye movement (REM) or dreaming sleep and on actual sleep. Oral administration of 100 mg. of chlorpromazine given during the daytime or at bedtime did not suppress REM sleep; in fact, the total REM sleep was increased proportionally to the increase in actual sleep.
KW  - Chlorpromazine--sleep-;
KW  - Tranquilizers--chlorpromazine--sleep, effects, in psychiatric patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Brown, C. H., III;
AU  - Carbone, P. P.;
T1  - Effects of chemotherapeutic agents on normal mouse bone marrow grown in vitro
CT  - Effects of chemotherapeutic agents on normal mouse bone marrow grown in vitro
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1971/02/01/
VL  - 31
IS  - Feb
SP  - 185
EP  - 190
SN  - 00085472
AD  - Medical Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-2776; Language: English; References: 18; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - The effects of several antineoplastic agents on normal mouse bone marrow were studied with the use of an enriched methylcellulose system. Twenty-four hours after incremental doses, cyclophosphamide, mechlorethamine, and carmustine resulted in exponential decreases in the fraction of surviving in vitro colony-forming units per femur, while vinblastine, methotrexate, and polyinosinic-polycytidylic acid gave dose-response curves which showed that, despite increasing doses, a maximal kill of colony-forming units was approached.
KW  - Antineoplastic agents--effects--on normal mouse bone marrow grown in vitro;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lawson, C. L.
AU  - Slagle, James R.
AU  - Farrell, Carl D.
T1  - Experiments in Automatic Learning for a Multipurpose Heuristic Program.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1971/02//
VL  - 14
IS  - 2
M3  - Article
SP  - 91
EP  - 99
SN  - 00010782
AB  - An automatic learning capability has been developed and implemented for use with the MULTIPLE (MULTIpurpose Program that LEarns) heuristic tree-searching program, which is presently being applied to resolution theorem-proving in predicate calculus. MULTIPLE's proving program (PP) uses two evaluation functions to guide its search for a proof of whether or not a particular goal is achievable. Thirteen general features of predicate calculus clauses were created for use in the automatic learning of better evaluation functions for PP. A multiple regression program was used to produce optimal coefficients for linear polynomial functions in terms of the features. Also, automatic data-handling routines were written for passing data between the learning program and the proving program, and for analyzing and summarizing results. Data was generally collected for learning (regression analysis) from the experience of PP. A number of experiments were performed to test the effectiveness and generality of the learning program. Results showed that the learning produced dramatic improvements in the solutions to problems which were in the same domain as those used for collecting learning data. Learning was also shown to generalize successfully to domains other than those used for data collection. Another experiment demonstrated that the learning program could simultaneously improve performance on problems in a specific domain and on problems in a variety of domains. Some variations of the learning program were also tested. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPUTER programming
KW  - MATHEMATICAL analysis
KW  - REGRESSION analysis
KW  - MATHEMATICAL statistics
KW  - MULTIVARIATE analysis
KW  - CALCULUS -- Software
KW  - adaptive
KW  - artificial intelligence
KW  - automatic learning
KW  - heuristic
KW  - learning
KW  - LISP
KW  - multiple regression
KW  - problem-solving
KW  - resolution
KW  - self-modifying
KW  - theorem-providing
KW  - tree-searching
N1  - Accession Number: 5221545; Lawson, C. L.; Slagle, James R. 1; Farrell, Carl D. 2; Affiliations: 1: Stanford Artificial Intelligence Project, Stanford University, Stanford, California.; 2: Division of Computer Research and Technology, National Institutes of Health, Public Health Service.; Issue Info: Feb1971, Vol. 14 Issue 2, p91; Thesaurus Term: COMPUTER programming; Thesaurus Term: MATHEMATICAL analysis; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: MULTIVARIATE analysis; Subject Term: CALCULUS -- Software; Author-Supplied Keyword: adaptive; Author-Supplied Keyword: artificial intelligence; Author-Supplied Keyword: automatic learning; Author-Supplied Keyword: heuristic; Author-Supplied Keyword: learning; Author-Supplied Keyword: LISP; Author-Supplied Keyword: multiple regression; Author-Supplied Keyword: problem-solving; Author-Supplied Keyword: resolution; Author-Supplied Keyword: self-modifying; Author-Supplied Keyword: theorem-providing; Author-Supplied Keyword: tree-searching; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541519 Other Computer Related Services; Number of Pages: 9p; Illustrations: 8 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - GEN
AU  - Slagle, James R.
AU  - Lee, Richard C.T.
T1  - Application of Game Tree Searching Techniques to Sequential Pattern Recognition
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1971/02//
VL  - 14
IS  - 2
M3  - Article
SP  - 103
PB  - Association for Computing Machinery
SN  - 00010782
AB  - A sequential pattern recognition (s.p.r.) procedure does not test all the features of a pattern at once. Instead, it selects a feature to be tested. After receiving the result of that test, the procedure either classifies the unknown pattern or selects another feature to be tested, etc. Medical diagnosis is an example of s.p.r. In this paper the authors suggest that s.p.r. Be viewed as a one-person game played against nature (chance). Virtually all the powerful techniques developed for searching two-person, strictly competitive game trees can easily be incorporated either directly or by analogy into s.p.r. Procedures. In particular, one can incorporate the 'miniaverage backing-up procedure' and the 'gramma procedure,' which are the analogs of the 'minimax backing-up procedure' and the 'alpha-beta procedure,' respectively. Some computer-simulated experiments in character recognition are presented. The results indicate that the approach is promising.
KW  - COMPUTERS
KW  - ELECTRONIC data processing
KW  - SEQUENTIAL processing (Computer science)
N1  - Accession Number: 5221547; Slagle, James R.; Lee, Richard C.T. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: Feb71, Vol. 14 Issue 2, p103; Note: Publisher: Association for Computing Machinery; Note: Update Code: 0600; Subject Term: COMPUTERS; Subject Term: ELECTRONIC data processing; Subject Term: SEQUENTIAL processing (Computer science); Number of Pages: 8p; Illustrations: 13 diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - EVARTS, EDWARD V.
T1  - Neuroscience.
JO  - Science
JF  - Science
Y1  - 1971/02/19/
VL  - 171
IS  - 3972
M3  - Article
SP  - 667
EP  - 667
SN  - 00368075
N1  - Accession Number: 85058492; EVARTS, EDWARD V. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 2/19/1971, Vol. 171 Issue 3972, p667; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GESSA, G. L.
AU  - TAGLIAMONTE, A.
AU  - TAGLIAMONTE, P.
T1  - Aphrodisiac Effect of p-Chlorophenylalanine.
JO  - Science
JF  - Science
Y1  - 1971/02/19/
VL  - 171
IS  - 3972
M3  - Article
SP  - 706
EP  - 706
SN  - 00368075
N1  - Accession Number: 85058511; GESSA, G. L. 1; TAGLIAMONTE, A. 1; TAGLIAMONTE, P. 1; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/19/1971, Vol. 171 Issue 3972, p706; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Adamson, R. H.;
T1  - Antitumor activity of two antiviral drugs\M/rifampicin and tilorone
CT  - Antitumor activity of two antiviral drugs\M/rifampicin and tilorone
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1971/02/20/
VL  - 1
IS  - Feb 20
SP  - 398
SN  - 00237507
AD  - Section of Pharmacology and Experimental Therapeutics, Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0235; Language: English; Trade Name: Rifampicin; Generic Name: Rifampin; Chemical Name: Rifampin--13292-46-1 Tilorone--27591-97-5; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents rifampin (10:00); AHFS Class: Antineoplastic agents tilorone; Publication Type: Letters; Journal Coden: LANCAO; Section Heading: Preliminary Drug Testing; Abstract Author: Douglas L. Thompson
N2  - The antitumor activity of rifampicin (rifampin) and tilorone hydrochloride in ascitic Walker 256 carcinosarcoma was investigated. Both drugs were active against the tumor. Rifampin was equivalent in antitumor activity to poly I.poly C, but tilorone was more effective than either rifampin or poly I.poly C.
KW  - Rifampin--antineoplastic agents-;
KW  - Tilorone--hydrochloride-;
KW  - Antineoplastic agents--rifampin--effects, against Walker 256 carcinosarcoma, in animals;
KW  - Antineoplastic agents--tilorone--hydrochloride, effects, against Walker 256 carcinosarcoma, in animals;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - NICOLL, R. A.
T1  - Recurrent Excitation of Secondary Olfactory Neurons: A Possible Mechanism for Signal Amplification.
JO  - Science
JF  - Science
Y1  - 1971/02/26/
VL  - 171
IS  - 3973
M3  - Article
SP  - 824
EP  - 826
SN  - 00368075
AB  - Secondary neurons of the olfactory bulb can be excited monosynaptically after activation of neighboring secondary neurons by antidromic and orthodromic volleys. Recurrent collaterals of secondary neurons are proposed to synapse with other secondary neurons, thus forming a direct recurrent excitatory pathway. Such a positive feedback system could strengthen the original input signal. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85138366; NICOLL, R. A. 1; Affiliations: 1: National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/26/1971, Vol. 171 Issue 3973, p824; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Williams, R. B.;
AU  - Sherter, C.;
T1  - Cardiac complications of tricyclic antidepressant therapy
CT  - Cardiac complications of tricyclic antidepressant therapy
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/03/01/
VL  - 74
IS  - Mar
SP  - 395
EP  - 398
SN  - 00034819
AD  - reprints: Section of Psychobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20014
AD  - Department of Internal Medicine, Yale-New Haven Hospital, and the Veterans Administration Hospital, West Haven, Connecticut
N1  - Accession Number: 8-1892; Language: English; Chemical Name: Amitriptyline--50-48-6 Imipramine--50-49-7; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants amitriptyline (28:16.04); AHFS Class: Antidepressants imipramine; References: 26; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions
N2  - Two similar fatal cases of unresponsive cardiac standstill secondary to toxicity of tricyclic antidepressants are reported. One is a case of deliberate overdose (1.6 g.) of amitriptyline and the other represents toxicity of therapeutic doses of imipramine (25 mg. 3 times daily) in a patient pretreated with a catecholamine depleting agent (guanethidine). Tricyclic amine antidepressants block the uptake of catecholamines by the heart, allowing enzymatic degradation and further catecholamine depletion. This group of antidepressants should therefore be contraindicated in patients receiving drugs that deplete cardiac catecholamines.
KW  - Amitriptyline--toxicity-;
KW  - Imipramine--toxicity-;
KW  - Antidepressants--amitriptyline--toxicity, fatal, overdose results in cardiac complications;
KW  - Antidepressants--imipramine--toxicity, fatal, cardiac complications;
KW  - Toxicity--amitriptyline--fatal, overdose, causes cardiac complications;
KW  - Toxicity--imipramine--cardiac complications, fatal;
KW  - Antidepressants--tricyclic--amines, contraindications, in patients receiving drugs that deplete cardiac catecholamines;
KW  - Contraindications--antidepressants--tricyclic, amines, in patients receiving drugs that deplete cardiac catecholamines, fatal cases;
KW  - Drug interactions--antidepressants--tricyclic amines, and drugs depleting cardiac catecholamines, fatal cases;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carter, S. K.;
AU  - Broder, L.;
AU  - Friedman, M.;
T1  - Streptozotocin and metastatic insulinoma
CT  - Streptozotocin and metastatic insulinoma
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/03/01/
VL  - 74
IS  - Mar
SP  - 445
EP  - 446
SN  - 00034819
AD  - Cancer Therapy Evaluation Branch, National Cancer Institute, Bethesda, Maryland
N1  - Accession Number: 8-1670; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin; References: 12; Publication Type: Editorial; Journal Coden: AIMEAS; Section Heading: Preliminary Drug Testing; Pharmacology; Abstract Author: Judith A. Kepler
N2  - The history and development of the antineoplastic antibiotic, streptozotocin is outlined. The unique diabetogenic potential observed in large animal toxicology studies pointed the way toward trials in the treatment of metastatic insulinoma. Clinical data on the drug accumulated to date is reviewed.
KW  - Streptozotocin--history-;
KW  - Toxicity studies--streptozotocin--diabetogenic potential indicates usefulness in metastatic insulinoma;
KW  - Antineoplastic agents--streptozotocin--insulinoma, metastatic, therapy;
KW  - History--streptozotocin--and development, and use in metastatic insulinoma;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hansen, H. H.;
AU  - Selawry, O. S.;
AU  - Muggia, F. M.;
AU  - Walker, M. D.;
T1  - Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037)
CT  - Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037)
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1971/03/01/
VL  - 31
IS  - Mar
SP  - 223
EP  - 227
SN  - 00085472
AD  - National Cancer Institute\M/Veterans Administration Medical Oncology Service, Medical Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-1629; Language: English; Trade Name: NSC-79037; Generic Name: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; References: 19; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Jimmie L. Hall
N2  - In this study, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037) was administered to 40 patients with advanced cancer in order to determine its maximum tolerated dose, to explore tolerance to repeated doses, and to make preliminary observations on its possible therapeutic effects. The initial dose of NSC-79037 was 15 mg./m.\SU/2\BS/, given orally. Progressively larger doses were given at 2 to 8 week intervals. The maximum dose was determined to be 130 mg./m.\SU/2 \BS/every 6 weeks. Nausea, vomiting, and anorexia were frequent adverse effects. One patient reported shortness of breath and swelling of the face. Thrombocytopenia and leukopenia were the most consistent dose-limiting side effects. Objective responses at toxic doses were seen in 2 of 5 patients with evaluable bronchogenic carcinoma and in both patients with malignant lymphoma. Marked neurological improvement was noted in all 3 patients with glioblastoma multiforme.
KW  - 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea--effects-;
KW  - Antineoplastic agents--1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea--effects, in patients with advanced cancer;
KW  - Dosage--1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea--in patients with advanced cancer;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Gazdar, A. F.
AU  - Beitzel, W.
AU  - Talal, N.
T1  - THE AGE RELATED RESPONSES OF NEW ZEALAND MICE TO A MURINE SARCOMA VIRUS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1971/03//
VL  - 8
IS  - 3
M3  - Article
SP  - 501
EP  - 509
SN  - 00099104
AB  - The Moloney strain of murine sarcoma virus (MSV-M) rapidly induces soft tissue tumours in mice of all ages. Immunologically competent mice can spontaneously regress these tumours, and the regression time is an indication of the degree of immunologic reactivity. Using these parameters. New Zealand Black (NZB), New Zealand White × New Zealand Black F1 (B/W), and NIH Swiss mice develop cell mediated immune responses at an early age compared to five other mouse strains. 8-11-month-old NZB and B/W mice of both sexes show depressed immune responses when compared to 6-week-old controls. The responses of 10-11 month old female BALB/c mice were identical to 6-week-old controls. Older IMZB and B/W mice spontaneously develop autoimmune disease. Measurement of autoimmune parameters in the older New Zealand mouse strains indicates that immune depression precedes the onset of detectable autoimmune disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MURINE sarcoma viruses
KW  - RETROVIRUSES
KW  - IMMUNE response
KW  - IMMUNOLOGY
KW  - AUTOIMMUNE diseases
KW  - TUMORS
N1  - Accession Number: 14549856; Gazdar, A. F. 1; Beitzel, W. 1; Talal, N. 1; Source Information: Mar1971, Vol. 8 Issue 3, p501; Subject: MURINE sarcoma viruses; Subject: RETROVIRUSES; Subject: IMMUNE response; Subject: IMMUNOLOGY; Subject: AUTOIMMUNE diseases; Subject: TUMORS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Vesell, E.;
AU  - Page, J. G.;
AU  - Passananti, T.;
T1  - Genetic and environmental factors affecting ethanol metabolism in man
CT  - Genetic and environmental factors affecting ethanol metabolism in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1971/03/01/
VL  - 12
IS  - Mar-Apr (Part 1)
SP  - 192
EP  - 201
SN  - 00099236
AD  - Section on Pharmacogenetics, Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0450; Language: English; Trade Name: Phenazone; Generic Name: Antipyrine; Chemical Name: Antipyrine--60-80-0; References: 35; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2  - The relative contribution of genetic and environmental factors to maintaining twofold differences in rates of ethanol elimination from plasma was examined in 14 sets of nonmedicated, nonhospitalized healthy twins. After a single oral dose of 1 ml./kg. of 95% ethanol, intrapair differences in rates of elimination were less in identical than in fraternal twins. These results indicate that individual differences in rates of ethanol elimination among the 28 twins were genetically controlled and that environmental factors played a negligible role. In 6 prisoners in solitary confinement, rates of ethanol metabolism increased in 3 but declined in the remaining 3 after 21 days of ethanol administration. Rates of antipyrine (phenazone) elimination from plasma were accelerated by ethanol administration in each of the 6 volunteers. Considerable individual variation occurred in the degree to which ethanol shortened plasma antipyrine half-lives; reduction ranged from 4 to 37% of the initial antipyrine half-life. These results suggest that ethanol administration for 21 days at this dosage fails to alter consistently the rate of its own metabolism but increases antipyrine metabolism in all subjects to varying extents.
KW  - Antipyrine--blood levels-;
KW  - Alcohols--ethyl--metabolism, genetic and environmental factors affecting, in man;
KW  - Metabolism--alcohols--ethyl, genetic and environmental factors affecting, in man;
KW  - Metabolism--antipyrine--blood levels, effects, ethyl alcohol, in man;
KW  - Blood levels--antipyrine--effects, ethyl alcohol, in man;
KW  - Half-life--antipyrine--effects, ethyl alcohol, in man;
KW  - Blood levels--alcohols--ethyl, effects, genetic and environmental factors, in man;
KW  - Pharmacogenetics--alcohols--ethyl, factors affecting metabolism, in man;
KW  - Drug interactions--antipyrine--blood levels, effects, ethyl alcohol;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dunner, D. L.;
AU  - Brodie, H. K. H.;
T1  - Plasma dopa response to levodopa administration in man: effects of a peripheral decarboxylase inhibitor
CT  - Plasma dopa response to levodopa administration in man: effects of a peripheral decarboxylase inhibitor
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1971/03/01/
VL  - 12
IS  - Mar-Apr (Part 1)
SP  - 212
EP  - 217
SN  - 00099236
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0451; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 16; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2  - Plasma dopa levels were determined in depressed patients at various times after oral administration of levodopa with and without a peripheral decarboxylase inhibitor, D,L-alpha-methyldopa hydrazine (MK-485). Pretreatment with MK-485 caused an approximately tenfold increase in the peak plasma levels following a dopa load. Equivalent plasma levels were achieved with one-tenth the dose of levodopa with use of MK-485. A significant prolongation of the half-life of the amino acid in the plasma was also achieved. The increase of plasma dopa levels with MK-485 is in the same range as the potentiation of the clinical effect with this inhibitor.
KW  - Levodopa--alone-;
KW  - MK-485--and levodopa-;
KW  - Drug interactions--levodopa and MK-485--potentiation, in depressed patients;
KW  - Enzyme inhibitors--MK-485--potentiation, levodopa, in depressed patients;
KW  - Antiparkinson agents--levodopa--alone, and with MK-485, effects, plasma dopa levels, in depressed patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Martin, W. R.;
AU  - Sloan, J. W.;
AU  - Sapira, J. D.;
AU  - Jasinski, D. R.;
T1  - Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
CT  - Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1971/03/01/
VL  - 12
IS  - Mar-Apr (Part 1)
SP  - 245
EP  - 258
SN  - 00099236
AD  - National Institute of Mental Health, Addiction Research Center, United States Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1  - Accession Number: 9-0591; Language: English; Chemical Name: Amphetamine--300-62-9 Methamphetamine--537-46-2 Ephedrine--299-42-3 Phenmetrazine--134-49-6 Methylphenidate--113-45-1; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine (28:20); AHFS Class: Central nervous system stimulants methamphetamine (28:20); AHFS Class: Central nervous system stimulants ephedrine (28:20); AHFS Class: Central nervous system stimulants phenmetrazine (28:20); AHFS Class: Central nervous system stimulants methylphenidate; References: 25; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2  - The effects of d-amphetamine, d-methamphetamine, phenmetrazine, methylphenidate, and ephedrine, on several physiologic, behavioral, and neurochemical parameters were compared in order to delineate their mode or modes of action in producing subjective reactions. All of these centrally acting sympathomimetic amines increased blood pressure and respiratory rate, produced similar types of subjective changes, and increased the excretion of epinephrine. With regard to these parameters, there was a high concordance between estimates of their relative potencies. The concordance between the potency estimates for the different parameters suggests, but does not prove, that these 5 agents share a common mode of central action. Further, if the peripheral modes of action as elucidated by animal studies are true for man, this study suggests that it is unlikely that their central actions in man are a consequence of the release of norepinephrine in the brain.
KW  - Amphetamine--mechanism of action-;
KW  - Methamphetamine--mechanism of action-;
KW  - Ephedrine--mechanism of action-;
KW  - Phenmetrazine--mechanism of action-;
KW  - Methylphenidate--mechanism of action-;
KW  - Central nervous system stimulants--amphetamine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW  - Central nervous system stimulants--methamphetamine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW  - Central nervous system stimulants--ephedrine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW  - Central nervous system stimulants--phenmetrazine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW  - Central nervous system stimulants--methylphenidate--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW  - Mechanism of action--central nervous system stimulants--physiologic, subjective and behavioral effects, in man;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodwin, F. K.;
AU  - Murphy, D. L.;
AU  - Brodie, H. K. H.;
AU  - Bunney, W. E., Jr.;
T1  - Levodopa: alterations in behavior
CT  - Levodopa: alterations in behavior
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1971/03/01/
VL  - 12
IS  - Mar-Apr (Part 2)
SP  - 383
EP  - 396
SN  - 00099236
AD  - Section of Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0749; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 38; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology
N2  - Results on the use of sustained high doses of levodopa in depressed patients are presented, and the psychiatric side effects encountered during the therapeutic use of the drug in Parkinson's disease are discussed against the background of the hypothesized role of catecholamines in the pathogenesis of affective disorders. One half of the patients were treated with smaller doses of levodopa in combination with a peripheral decarboxylase inhibitor (MK-485). Only 6 of 21 depressed patients consistently improved on levodopa, with relapse following placebo substitution and remission on restoration of the drug. A statistically significant increase in anger rating following 5 days of maximal dose of levodopa was noted as compared with that prior to treatment; others who previously experienced manic episodes manifested hypomanic behavior during treatment. Doses large enough to produce hypomania did not reverse depression. It is concluded that: (1) amine depletion does not explain the pathophysiology of depression in most patients; (2) hypomania occurs almost exclusively in affectively labile individuals; (3) the catecholamine hypothesis for depression may be an oversimplification in that mania and depression do not appear to represent the opposite poles of a single biochemical continuum; and (4) many factors contribute to psychiatric side effects\M/the pre-dopa psychiatric state being the most important variable, levodopa often serving to unmask pre-existing psychopathology.
KW  - Levodopa--toxicity-;
KW  - Toxicity--levodopa--side effects, psychiatric, in depressed patients following high dosage;
KW  - Dosage--levodopa--high, sustained, psychiatric side effects in depressed patients;
KW  - Antiparkinson agents--levodopa--side effects, psychiatric, in depressed patients following high dosage;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Eddy, N. B.;
AU  - Jacobson, A. E.;
T1  - Agonists-antagonists
CT  - Agonists-antagonists
JO  - Curr. Med. Dialog
JF  - Curr. Med. Dialog
Y1  - 1971/03/01/
VL  - 38
IS  - Mar
SP  - 330
EP  - 338
AD  - National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-3164; Language: English; Chemical Name: Morphine--57-27-2; References: 36; Section Heading: Pharmacology; Abstract Author: Brenda Sue Martinez
N2  - A morphine antagonist was defined as a drug which, in at least some dosage range, can cancel or reverse morphine or morphine-like (agonist) pharmacologic effects. Certain effects of the narcotic antagonists nalorphine, levallorphan, pentazocine, and naloxone were described. For example, simultaneous administration of an agonist and an antagonist resulted in retention of analgesic effect while reducing the possibility of respiratory depression and other side effects. Based on a potency of 1.0 for nalorphine, results of animal tests for analgesic activity of agonists and antagonists were compared to the analgesia produced in man and are listed in table format. Similarly, antagonist activity of agonists and antagonists against the effect of morphine in isolated guinea pig ileum and for precipitation of withdrawal syndrome in addicted monkeys versus physical dependence liability in man were presented in another table. Naloxone, which has no significant analgesic action, no respiratory depressant or bizarre side effects, and antagonizes agonists and other antagonists, was considered a #OQ#OQpure'' antagonist.
KW  - Morphine--agonists-;
KW  - Narcotic antagonists--and agonists--discussion;
KW  - Narcotics--discussion--of agonists and antagonists;
KW  - Drugs--agonists--and antagonists, of narcotics, discussion;
KW  - Analgesics and antipyretics--narcotics--discussion, of agonists and antagonists;
KW  - Drug interactions--narcotics--discussion, of agonists and antagonists;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - Analysis of Binary Data (Book).
JO  - Operations Research
JF  - Operations Research
Y1  - 1971/03//Mar/Apr71
VL  - 19
IS  - 2
M3  - Book Review
SP  - 552
EP  - 552
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - Reviews the book "Analysis of Binary Data," by D.R. Cox.
KW  - BINARY system (Mathematics)
KW  - NONFICTION
KW  - COX, D. R.
KW  - ANALYSIS of Binary Data (Book)
N1  - Accession Number: 8601752; Weiss, George H. 1; Affiliations: 1: National Institutes of Health Bethesda, Maryland.; Issue Info: Mar/Apr71, Vol. 19 Issue 2, p552; Subject Term: BINARY system (Mathematics); Subject Term: NONFICTION; Reviews & Products: ANALYSIS of Binary Data (Book); People: COX, D. R.; Number of Pages: 1/2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2005-10331-006
AN  - 2005-10331-006
AU  - Shore, Milton F.
ED  - Shore, Milton F.
T1  - The Federal Scene.
JF  - Professional Psychology
JO  - Professional Psychology
JA  - Prof Psychol
Y1  - 1971///Spr 1971
VL  - 2
IS  - 2
SP  - 200
EP  - 201
CY  - US
PB  - American Psychological Association
SN  - 0033-0175
N1  - Accession Number: 2005-10331-006. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Shore, Milton F.; Clinical Research and Program Evaluation Section, Mental Health Study Center, National Institute of Mental Health, US. Release Date: 20060327. Correction Date: 20100412. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Column/Opinion. Language: English. Major Descriptor: Government Agencies; Mental Health Services; Psychology; Public Sector; Scientific Communication. Classification: Professional Psychological & Health Personnel Issues (3400). Location: US. Page Count: 2. Issue Publication Date: Spr 1971. Copyright Statement: American Psychological Association. 1971. 
AB  - Notes that despite the major changes in the mental health field since the establishment of the National Institute of Mental Health, professional psychologists often have limited understanding of the activities on a federal level. One example is how few people are aware that the National Institute of Mental Health has had since 1948 an operating agency, the Mental Health Study Center. Professionals are also often unaware of government publications of major interest to professional psychologists, since these books and pamphlets are rarely reviewed or discussed in professional journals. Publications noted include 3 bibliographies recently published by the Government Printing Office: 1) 'Coping and Adaptation: A Behavioral Sciences Bibliography' by G. V. Coelho, D. A. Hamburg, R. Moose, and P. Randolph; 2) 'Consultation in Mental Health and Related Fields: A Reference Guide' by F. V. Mannino, described as the most complete bibliography on mental health consultation yet available; and 3) 'Bibliography on Human Intelligence' by Logan Wright. Also noted is 'Mental Health Consultation to Programs for Children: A Review of Data Collected from Selective U.S. Sites' by by S. B. McClung and A. A. Stunden. The event in Washington which most involved mental health professions at the end of 1970 was the White House Conference on Children (December 13-18, 1970). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - National Institute of Mental Health
KW  - publications
KW  - 1971
KW  - Government Agencies
KW  - Mental Health Services
KW  - Psychology
KW  - Public Sector
KW  - Scientific Communication
KW  - 1971
DO  - 10.1037/h0020705
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SEMMES, JOSEPHINE
T1  - Cortical Connections.
JO  - Science
JF  - Science
Y1  - 1971/03/05/
VL  - 171
IS  - 3974
M3  - Article
SP  - 885
EP  - 886
SN  - 00368075
N1  - Accession Number: 85104384; SEMMES, JOSEPHINE 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 3/ 5/1971, Vol. 171 Issue 3974, p885; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHENEY, D. L.
AU  - GOLDSTEIN, A.
AU  - ALGERI, S.
AU  - COSTA, E.
T1  - Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain.
JO  - Science
JF  - Science
Y1  - 1971/03/19/
VL  - 171
IS  - 3976
M3  - Article
SP  - 1169
EP  - 1170
SN  - 00368075
AB  - Serotonin turnover was measured in mouse brain by means of the conversion of radioactivity from labeled tryptophan into serotonin. Animals with a high degree of tolerance to and physical dependence on morphine did not differ from control mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002396; CHENEY, D. L. 1; GOLDSTEIN, A. 1; ALGERI, S. 2; COSTA, E. 2; Affiliations: 1: Department of Pharmacology, Stanford University, Stanford, California 94305; 2: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/19/1971, Vol. 171 Issue 3976, p1169; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Crane, G. E.;
T1  - Persistence of neurological symptoms due to neuroleptic drugs
CT  - Persistence of neurological symptoms due to neuroleptic drugs
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1971/04/01/
VL  - 127
IS  - Apr
SP  - 1407
EP  - 1410
SN  - 0002953X
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 8-2678; Language: English; References: 12; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity
N2  - The author examines the problem of extrapyramidal symptoms attributable to neuroleptic drugs. Thirty-nine patients with tardive dyskinesia and/or pseudoparkinsonism did not receive neuroleptics for 6 to 24 months. At the end of this time, 36 patients manifested symptoms consistent with tardive dyskinesia. In 5 of the 12 patients who had pseudoparkinsonism, alone or with tardive dyskinesia, parkinsonian symptoms persisted for 6 months or longer.
KW  - Psychotherapeutic agents--toxicity studies--examination of extrapyramidal symptoms attributable to neuroleptic agents;
KW  - Toxicity studies--psychotherapeutic agents--examination of extrapyramidal symptoms attributable to neuroleptic agents;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Simmons, Roberta G.
AU  - Rosenberg, Morris
T1  - FUNCTIONS OF CHILDREN'S PERCEPTIONS OF THE STRATIFICATION SYSTEM.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1971/04//
VL  - 36
IS  - 2
M3  - Article
SP  - 235
EP  - 249
SN  - 00031224
AB  - The purpose of this study has been to examine children's perceptions of the stratification system and to consider the possible consequences of these perceptions for the larger social order. There has been an attempt to extend one aspect of Davis and Moore's classical stratification theory by exploring the status attitudes requisite for an adequate number of children to strive toward prestigious, socially-important occupations. A sample of 1,917 black and white children from grades 3-12 from Baltimore City were interviewed. Findings indicate that young children have developed a type of status consciousness that should facilitate such occupational striving: that is, a clear awareness of occupational prestige differences as early as third grade (based on a comparison with 1963 adult North-Hatt ratings), and a continuing optimism about their own opportunities to achieve desirous occupations. In addition, several mechanisms are noted that appear to be dampening anger against the class system among the disadvant[a]ged school children. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL stratification
KW  - SOCIAL structure
KW  - PRESTIGE
KW  - SOCIAL psychology
KW  - SOCIAL status
KW  - INTERVIEWS
KW  - CHILDREN
N1  - Accession Number: 14896566; Simmons, Roberta G. 1; Rosenberg, Morris 2; Affiliations: 1 : University of Minnesota.; 2 : National Institute of Mental Health.;  Source Info: Apr71, Vol. 36 Issue 2, p235; Historical Period: 1963 to 1971; Subject Term: SOCIAL stratification; Subject Term: SOCIAL structure; Subject Term: PRESTIGE; Subject Term: SOCIAL psychology; Subject Term: SOCIAL status; Subject Term: INTERVIEWS; Subject Term: CHILDREN; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
TY  - GEN
AU  - Morton, D. L.;
AU  - Holmes, E. C.;
AU  - Eilber, F. R.;
AU  - Wood, W. C.;
T1  - Immunological aspects of neoplasia: a rational basis for immunotherapy
CT  - Immunological aspects of neoplasia: a rational basis for immunotherapy
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/04/01/
VL  - 74
IS  - Apr
SP  - 587
EP  - 604
SN  - 00034819
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-2765; Language: English; References: 37; Publication Type: Edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda, Md., by the National Cancer Institute, National Institutes of Health, Department of Health, Education, and Welfare; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2  - During the past decade it has become increasingly apparent that cancer cells have acquired, during neoplastic transformation, new antigens not found in normal cells and that the host's immune response against these antigens is important in controlling the development and progression of malignancy. In immunologic and immunotherapeutic studies with human melanomas and sarcomas a remarkable correlation between the patient's immune response to his tumor and the extent and progression of malignant disease was found. Rising titers of antitumor antibody were consistently observed after surgical removal of the tumor mass in patients with sarcomas, whereas all patients with recurrent disease were found to have a progressive decline in their titers of antitumor antibody with advancing disease. Immunotherapy studies in guinea pigs and man have shown that active immunization with BCG vaccine and autologous tumor cells induced a heightened immune response against the tumor-associated antigens that was sometimes therapeutic.
KW  - BCG vaccines--and autologous tumor cells-;
KW  - Immunology--aspects--of neoplasia, a rational basis for immunotherapy;
KW  - Immunization--active--with BCG vaccine and autologous tumor cells, heightened immune response against tumor-associated antigens, in guinea pigs and man, discussion;
KW  - Antineoplastic agents--immunization--active, with BCG vaccine and autologous tumor cells, heightened immune response against tumor-associated antigens, in guinea pigs and man, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Paul, M. I.;
AU  - Cramer, H.;
AU  - Goodwin, F. K.;
T1  - Urinary cyclic AMP excretion in depression and mania
CT  - Urinary cyclic AMP excretion in depression and mania
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1971/04/01/
VL  - 24
IS  - Apr
SP  - 327
EP  - 333
AD  - Laboratory of Chemical Pharmacology, National Heart and Lung Institute and Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 9-4503; Language: English; Chemical Name: Lithium carbonate--554-13-2 Levodopa--59-92-7; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 28; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - The 24-hour urinary excretion patterns of adenosine 3', 5'-cyclic monophosphate (cyclic AMP) were examined in 40 patients with depression and/or mania and in 10 normal controls. The manic patients excreted the most cyclic AMP; when they were treated with lithium carbonate the urinary cyclic AMP diminished and their mania improved. The severely depressed patients excreted the least cyclic AMP; when 4 of them were treated with levodopa, 0.5-9 g./day, a marked increase in cyclic AMP was observed. The moderately depressed patients and control subjects excreted intermediate amounts of cyclic AMP. Consideration of various factors which may influence the urinary excretion pattern of cyclic AMP were presented.
KW  - Lithium carbonate--effects-;
KW  - Levodopa--effects-;
KW  - Psychotherapeutic agents--lithium carbonate--effects, cyclic AMP excretion, in patients with depression or mania;
KW  - Antiparkinson agents--levodopa--effects, cyclic AMP excretion, in patients with depression or mania;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cuskey, W. R.;
AU  - Moffett, A. D.;
AU  - Clifford, H. B.;
T1  - Comparison of female opiate addicts admitted to Lexington Hospital in 1961 and 1967
CT  - Comparison of female opiate addicts admitted to Lexington Hospital in 1961 and 1967
JO  - Health Serv. Rep.
JF  - Health Serv. Rep.
Y1  - 1971/04/01/
VL  - 86
IS  - Apr
SP  - 332
EP  - 339
AD  - reprints: Department of Community Medicine, 4219 Chester Avenue, Philadelphia, Pennsylvania 19104
AD  - Clinical Research Center, National Institute of Mental Health, Lexington, Kentucky
N1  - Accession Number: 9-0289; Language: English; References: 23; Journal Coden: HSRPAT; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: Anne W. Hatch
N2  - Two groups of female opiate addicts were compared by race as well as period of admission to Lexington hospital. Level of formal education, marital status, means of support, geographical distribution, status at admission (voluntary vs. committed), age, characteristics of abuse (type of drug and progression of drugs used), treatment effectiveness and cost are discussed.
KW  - Patients--addicts--opiates, female, admitted to Lexington hospital, comparison;
KW  - Opiates--dependence--female, comparison, of those admitted to Lexington Hospital;
KW  - Dependence--opiates--comparison of female addicts admitted to Lexington Hospital;
KW  - Drug abuse--opiates--comparison, of female addicts admitted to Lexington Hospital;
KW  - Costs--dependence--female opiate addicts at Lexington Hospital;
KW  - Sociology--dependence--female opiate addicts, comparison, at Lexington Hospital;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Baker, P. J.
AU  - Stashak, P. W.
AU  - Amsbaugh, Diana F.
AU  - Prescott, B.
T1  - Characterization of the Antibody Response to Type III Pneumococcal Polysaccharide at the Cellular Level I. DOSE-RESPONSE STUDIES AND THE EFFECT OF PRIOR IMMUNIZATION ON THE MAGNITUDE OF THE ANTIBODY RESPONSE.
JO  - Immunology
JF  - Immunology
Y1  - 1971/04//
VL  - 20
IS  - 4
M3  - Article
SP  - 469
EP  - 480
SN  - 00192805
AB  - The cytokinetics of the antibody to Type III pneumococcal polysaccharide (SSS-III) were characterized by an immuno-plaque procedure using erythrocytes sensitized with SSS-III. Prior immunization, irrespective of the doses employed, did not result in the development of immunological memory; instead, low-dose paralysis was produced in mice previously immunized with all doses of SSS-III. Dose-response studies revealed that within a given dose range, there was a direct relationship between the immunizing dose and the magnitude of the antibody response obtained. The dose-response curve for SSS-III showed a single optimal dose for immunization; doses only slightly in excess of the optimal dose produced a significant reduction in the magnitude of the antibody response. The implications of these findings, with respect to the development of paralysis to SSS-III, are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - POLYSACCHARIDES
KW  - IMMUNIZATION
KW  - IMMUNOLOGY
KW  - ERYTHROCYTES
KW  - BLOOD cells
N1  - Accession Number: 13362393; Baker, P. J. 1; Stashak, P. W. 1; Amsbaugh, Diana F. 1; Prescott, B. 2; Source Information: Apr71, Vol. 20 Issue 4, p469; Subject: IMMUNOGLOBULINS; Subject: POLYSACCHARIDES; Subject: IMMUNIZATION; Subject: IMMUNOLOGY; Subject: ERYTHROCYTES; Subject: BLOOD cells; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Baker, P. J.
AU  - Stashak, P. W.
AU  - Amsbaugh, Diana F.
AU  - Prescott, B.
T1  - Characterizaiton of the Antibody Response to Type III Pneumococcal Polysaccharide at the Cellular Level II. STUDIES ON THE RELATIVE RATE OF ANTIBODY SYNTHESIS AND RELEASE BY ANTIBODY-PRODUCING CELLS.
JO  - Immunology
JF  - Immunology
Y1  - 1971/04//
VL  - 20
IS  - 4
M3  - Article
SP  - 481
EP  - 492
SN  - 00192805
AB  - A procedure based on the rate of appearance of plaque-forming cells (PFC) in agarose was used to measure the relative rates of antibody synthesis and release by cells making antibody specific for Type III pneumococcal polysaccharide (SSS-III). The rate of antibody synthesis and release by SSS-III-specific PFC was directly related to the immunizing dose employed; maximal values were obtained with mice given an optimally immunogenic dose (0.5 µg) of SSS-III. However, dose-dependent reductions, not only in the magnitude of the antibody response, but also in the rate of antibody synthesis and release by specific PFC, were noted in mice receiving doses greater than 0.5 µg. The latter suggests that a decrease in the rate of antibody synthesis and release by antibody-forming cells may be an initial step in the induction of immunological paralysis by high doses of SSS-III. Increases in the magnitude of the serum antibody and the PFC response were associated with corresponding increases in the rate of antibody synthesis and release by SSS-III-specific PFC following immunization; this suggests that cell differentiation—rather than proliferation—plays a major rôle in the development of the antibody response to SSS-III. In contrast, the results obtained in similar studies with sheep erythrocytes indicate that cell proliferation influences to a greater degree the magnitude of the antibody response elicited to this antigen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - POLYSACCHARIDES
KW  - CELLS
KW  - IMMUNOLOGY
KW  - CELL proliferation
KW  - IMMUNIZATION
N1  - Accession Number: 13362407; Baker, P. J. 1; Stashak, P. W. 1; Amsbaugh, Diana F. 1; Prescott, B. 2; Source Information: Apr71, Vol. 20 Issue 4, p481; Subject: IMMUNOGLOBULINS; Subject: POLYSACCHARIDES; Subject: CELLS; Subject: IMMUNOLOGY; Subject: CELL proliferation; Subject: IMMUNIZATION; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Davey, M. Jean
AU  - Asherson, G. L.
AU  - Stone, S. H.
T1  - Selective and Specific Inhibition of 24 Hour Skin Reactions in the Guinea-Pig III. DEPRESSION OF CYTOPHILIC AND HAEMOLYTIC ANTIBODIES BY PRETREATMENT WITH ANTIGEN THE EFFECT OF IRRADIATION.
JO  - Immunology
JF  - Immunology
Y1  - 1971/04//
VL  - 20
IS  - 4
M3  - Article
SP  - 513
EP  - 522
SN  - 00192805
AB  - Dvorak and Flax (1966) and others reported that adult guinea-pigs pretreated with soluble antigens showed depressed immune responses following immunization with the same antigens in Freund's complete adjuvant. These depressed immune responses included haemolytic and cytophilic antibody and delayed hypersensitivity as well as antibody measured by passive cutaneous anaphylaxis and haemagglutination. This communication describes further studies on the effect of pretreatment with alum precipitated bovine γ-globulin rather than soluble antigen. Guinea-pigs given 1 mg of alum precipitated bovine γ-globulin prior to immunization with 50 µg bovine γ-globulin (BGG) in Freund's complete adjuvant show depressed haemolytic and cytophilic antibody and delayed hypersensitivity. This depression is immunologically specific as pretreatment with alum precipitated egg albumin does not depress immune responses to bovine γ-globulin. In contrast, antibody measured by passive cutaneous anaphylaxis and haemagglutination is either unaffected or raised. Similarly, pretreatment with sheep red cells reduces the cytophilic antibody response to sheep red cells in Freund's complete adjuvant. This depression is long lasting and 1 mg alum precipitated BGG depressed the haemolytic antibody response to BGG in adjuvant given 6 months later and the delayed hypersensitivity response to BGG in adjuvant given 9 months later. Alum precipitated BGG given up to 6 days after immunization with BGG in adjuvant caused some depression of haemolytic antibody. However, this depression was transient and much less than the long lasting depression caused by pretreatment with alum precipitated BGG 7 days before immunization with BGG in adjuvant. The effect of irradiation followed by alum precipitated BGG on the immune responses to BGG in Freund's complete adjuvant was also studied. 300 r depressed haemolytic and haemagglutinating antibody but had no effect on cytophilic antibody or delayed hypersensitivity. There was no synergy between irradiation and pretreatment with BGG; the depression of immune responses caused by irradiation followed by alum precipitated BGG was no greater than the depression caused by the more effective agent when given alone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - ANTIGENS
KW  - IRRADIATION
KW  - IMMUNE response
KW  - IMMUNITY
KW  - GUINEA pigs
N1  - Accession Number: 13362443; Davey, M. Jean 1; Asherson, G. L. 1; Stone, S. H. 1; Source Information: Apr71, Vol. 20 Issue 4, p513; Subject: IMMUNOGLOBULINS; Subject: ANTIGENS; Subject: IRRADIATION; Subject: IMMUNE response; Subject: IMMUNITY; Subject: GUINEA pigs; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Steinberg, Alfred D.
AU  - Pincus, Theodore
AU  - Talal, Norman
T1  - The Pathogenesis of Autoimmunity in New Zealand Mice III. FACTORS INFLUENCING THE FORMATION OF ANTI-NUCLEIC ACID ANTIBODIES.
JO  - Immunology
JF  - Immunology
Y1  - 1971/04//
VL  - 20
IS  - 4
M3  - Article
SP  - 523
EP  - 531
SN  - 00192805
AB  - The synthetic double stranded ribonucleic acids rI·rC and rA·rU were found to be immunogenic in normal mice when given without a protein carrier in Freund's complete adjuvant. When RNA was given without adjuvant, antibody could be detected only in New Zealand mice. Greater quantities of antibody were produced by females than males as in spontaneous disease. Sexual alteration did not alter this pattern. Spontaneous antibodies to RNA appeared before antibodies to DNA in NZB/ NZW mice, suggesting that a naturally occurring double stranded RNA may be a major factor in the spontaneous production of anti-nucleic acid antibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOIMMUNITY
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGICAL adjuvants
KW  - RNA
KW  - DNA
KW  - MICE
KW  - NEW Zealand
N1  - Accession Number: 13362464; Steinberg, Alfred D. 1; Pincus, Theodore 1; Talal, Norman 1; Source Information: Apr71, Vol. 20 Issue 4, p523; Subject: AUTOIMMUNITY; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGICAL adjuvants; Subject: RNA; Subject: DNA; Subject: MICE; Geographic Terms: NEW Zealand; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2013-41269-013
AN  - 2013-41269-013
AU  - Ryder, Robert G.
AU  - Kafka, John S.
AU  - Olson, David H.
T1  - Separating and joining influences in courtship and early marriage.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1971/04//
VL  - 41
IS  - 3
SP  - 450
EP  - 464
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Ryder, Robert G., Section on Family Development, Child Research Branch, National Institute of Mental Health, Building 1 5-K, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-41269-013. PMID: 5549916 Partial author list: First Author & Affiliation: Ryder, Robert G.; Section on Family Development, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Courtship; Life Changes; Marriage; Social Processes. Minor Descriptor: Early Experience; Social Interaction. Classification: Marriage & Family (2950). Population: Human (10). References Available: Y. Page Count: 15. Issue Publication Date: Apr, 1971. 
AB  - Transitional processes, such as getting married, are described in terms of the interaction of change-facilitating and change-resisting social forces. Lawful features of a transitional process include a non-arbitrary sequence of stages defined by reversals in the influence of particular classes of third party events. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - courtship
KW  - early marriage
KW  - life transition
KW  - social interaction
KW  - social processes
KW  - 1971
KW  - Human Courtship
KW  - Life Changes
KW  - Marriage
KW  - Social Processes
KW  - Early Experience
KW  - Social Interaction
KW  - 1971
DO  - 10.1111/j.1939-0025.1971.tb01131.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - GIELEN, J. E.
AU  - NEBERT, D. W.
T1  - Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p,p'-DDT.
JO  - Science
JF  - Science
Y1  - 1971/04/09/
VL  - 172
IS  - 3979
M3  - Article
SP  - 167
EP  - 169
SN  - 00368075
AB  - Aryl hydrocarbon hydroxylase induction hy phenoharhital, polycyclic hydrocarhons, and the insecticide, 2.2-bis(p-chlorophenyl)-1,1,1-trichloroethane(p,p'-DDT), occurs in rat fetal liver cell cultures. The maxinuun net rate at which the hydroxylase activity accumulates is about the same when phenobarbital, 3-methylcholanthrene, or benz[a]anthracene is in the growth medium at optimum concentrations. An additive effect is obtained when either phenoharhital or p,p'DDT is present with a polycyclic hYdrocarbon in the growth medium, but not when the cells are treated with phenoharhital plus p,p'-DDT or with the combination of two polycyclic hydrocarhons. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104483; GIELEN, J. E. 1; NEBERT, D. W. 1,2; Affiliations: 1: Section on Developmental Enzymology, Laboratory of Biomedical Sciences, National Institute of Child Health, Bethesda, Maryland 20014; 2: Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 9/1971, Vol. 172 Issue 3979, p167; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BRADY, ROSCOE O.
AU  - UHLENDORF, B. WILLIAM
AU  - JACOBSON, CECIL B.
T1  - Fabry's Disease: Antenatal Detection.
JO  - Science
JF  - Science
Y1  - 1971/04/09/
VL  - 172
IS  - 3979
M3  - Article
SP  - 174
EP  - 175
SN  - 00368075
AB  - A procedure is described for the intrauterine detection, at the 17th week of gestation, of a male fetus afflicted with Fabry's disease. The validity of this determination was substantiated by multiple enzyme and lipid analyses of tissue specimens obtained from the afflicted fetus. Fabry's disease may now be included with other X-linked metabolic deficiency diseases that are amenable to precise genetic counseling, through carrier identification, and the monitoring of ensuing pregnancies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104486; BRADY, ROSCOE O. 1; UHLENDORF, B. WILLIAM 2; JACOBSON, CECIL B. 3; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Neurological Diseases and Blindness, Bethesda, Maryland 20014; 2: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; 3: Department of Obstetrics and Gynecology, George Washington University School of Medicine, Washington, D.C. 20005; Issue Info: 4/ 9/1971, Vol. 172 Issue 3979, p174; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ZBAR, BERTON
AU  - TANAKA, TOMIKO
T1  - Immunotherapy of Cancer: Regression of Tumors after Intralesional Injection of Living Mycobacterium bovis.
JO  - Science
JF  - Science
Y1  - 1971/04/16/
VL  - 172
IS  - 3980
M3  - Article
SP  - 271
EP  - 273
SN  - 00368075
AB  - Injection of living Mycobacterium bovis (strain BCG) into established intradermal tumors caused tumor regression and prevented the development of metastases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87499068; ZBAR, BERTON 1; TANAKA, TOMIKO 1; Affiliations: 1: Cellular Immunity Section, Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/16/1971, Vol. 172 Issue 3980, p271; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Larson, H. E.;
AU  - Parkman, P. D.;
AU  - Davis, W. J.;
AU  - Hopps, H. E.;
AU  - Meyer, H. M.;
T1  - Inadvertent rubella virus vaccination during pregnancy
CT  - Inadvertent rubella virus vaccination during pregnancy
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/04/22/
VL  - 284
IS  - Apr 22
SP  - 870
EP  - 873
SN  - 00284793
AD  - Laboratory of Viral Immunology, Division of Biologics Standards, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 9-1182; Language: English; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2  - Studies concerning 9 pregnant women inadvertently inoculated with live rubella virus vaccine confirmed that the attenuated virus can produce chronic placental infection. None of the women had been tested for rubella susceptibility before vaccination; however, serologic testing of later serum specimens indicated seroconversion of one. This subject and one other reported symptoms consistent with vaccine-virus infection. In both women the attenuated virus was isolated from conceptuses collected 69 and 28 days respectively after immunization. Attempts at virus isolation were negative on specimens from the remaining 6 women. Histologic changes in placenta or decidua consistent with rubella infection were detected in the 2 virus-positive cases and in one negative case. These data underscore the need for caution in vaccinating postpubertal women.
KW  - Rubella vaccines--toxicity-;
KW  - Toxicity--rubella vaccines--inadvertent live virus vaccination results in chronic placental infection, in women;
KW  - Placental transfer--rubella vaccines--chronic placental infection in mothers inadvertently receiving live virus vaccine during pregnancy;
KW  - Metabolism--rubella vaccines--placental transfer, results in chronic placental infection due to inadvertent live virus vaccination, in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Henkin, R. I.;
AU  - Smith, F. R.;
T1  - Hyposmia in acute viral hepatitis
CT  - Hyposmia in acute viral hepatitis
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1971/04/24/
VL  - 1
IS  - Apr 24
SP  - 823
EP  - 826
SN  - 00237507
AD  - Section on Neuroendocrinology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-1265; Language: English; Chemical Name: Pyridine--100-86-1 Nitrobenzene--98-95-3 Thiophene--110-02-1; References: 15; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Nineteen patients with acute viral hepatitis have been found to have decreased olfactory acuity (hyposmia) which is associated with dysosmia and dysgeusia. Olfactory acuity was measured with 3 vapors\M/pyridine in water and nitrobenzene and thiophene in mineral oil. Hyposmia, called type-II hyposmia, lessened as the illness subsided. Improvement in olfactory acuity was inversely related to the plasma bilirubin and directly related to the plasma retinol binding protein level. Abnormalities of olfaction and taste may be major factors in the anorexia of hepatitis. Measurement of olfactory acuity is a rapid, simple means of assessing and monitoring hepatic function.
KW  - Pyridine--vapors-;
KW  - Nitrobenzene--vapors-;
KW  - Thiophene--vapors-;
KW  - Tests--olfactory--in patients with acute viral hepatitis;
KW  - Smell--tests--olfactory acuity measured in patients with acute viral hepatitis;
KW  - Methodology--measurement of olfactory acuity--in patients with acute viral hepatitis;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Chrambach, A.
AU  - Rodbard, D.
T1  - Polyacrylamide Gel Electrophoresis.
JO  - Science
JF  - Science
Y1  - 1971/04/30/
VL  - 172
IS  - 3982
M3  - Article
SP  - 440
EP  - 451
SN  - 00368075
N1  - Accession Number: 85104536; Chrambach, A. 1; Rodbard, D. 1; Affiliations: 1: Senior investigator, Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p440; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NG, K. Y.
AU  - CHASE, T. N.
AU  - COLBURN, R. W.
AU  - KOPIN, I. J.
T1  - Dopamine: Stimulation-Induced Release from Central Neurons.
JO  - Science
JF  - Science
Y1  - 1971/04/30/
VL  - 172
IS  - 3982
M3  - Article
SP  - 487
EP  - 489
SN  - 00368075
AB  - Dopamine, synthesized in rat brain slices from labeled L-tyrosine or L-dopa, can be released by electrical stimulation of a type known to induce neuronal depolarization. Pretreatment of the animals with 6-hydroxydopamine, which destroys central catecholamine-containing nerve terminals, substantially reduced the release of dopamine synthesized from [14C]tyrosine or from a low concentration of [³H]dopa, whereas the release of dopamine formed from a high concentration of [³H]dopa remained essentially unchanged. The observations that at high concentrations L-dopa may enter noncatecholaminergic cells, undergo decarboxylation to dopamine, and subsequently be liberated in response to depolarization suggest that dopamine may act as a substitute central transmitter, possibly in serotonergic neurons. This mechanism may contribute to L-dopa's clinical effects in parkinsonian patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85104558; NG, K. Y. 1; CHASE, T. N. 1; COLBURN, R. W. 1; KOPIN, I. J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p487; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Carter Jr., Jerry W.
T1  - THE COMMUNITY SERVICES PROGRAM OF THE NATIONAL INSTITUTE OF MENTAL HEALTH, U. S. PUBLIC HEALTH SERVICE.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1950/04//
VL  - 6
IS  - 2
M3  - Article
SP  - 112
EP  - 117
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article reports on the community services program of the national institute of mental health, U. S. public health service. Following World War II, congressional hearings revealed that various mental and emotional disorders and inadequacies accounted for the rejection or discharge of 2,000,000 men by the armed services. It was found that more than half of the patients hospitalized in the United States on any given day--some 600,000--were mental patients, and that about 8,000,000 individuals in the country were suffering from some mental disorder. No adequate programs for the prevention and early treatment of mental illness existed anywhere in the country. A National Advisory Mental Health Council consisting of leading scientific and medical authorities is provided for in the National Mental Health Act. This body advises the Surgeon General on such matters as policy, the distribution of grant funds, personnel standards, and other problems relating to the program.
KW  - MENTALLY ill -- Care
KW  - MENTAL health
KW  - NATIONAL health services
KW  - HUMAN services
KW  - PUBLIC health
KW  - MENTALLY ill
KW  - UNITED States
N1  - Accession Number: 15828812; Carter Jr., Jerry W. 1; Affiliation:  1: Chief Clinical Psychologist, Community Services Branch, National institute of Mental Health, U. S. Public Health Service.; Source Info: Apr1950, Vol. 6 Issue 2, p112; Subject Term: MENTALLY ill -- Care; Subject Term: MENTAL health; Subject Term: NATIONAL health services; Subject Term: HUMAN services; Subject Term: PUBLIC health; Subject Term: MENTALLY ill; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Perkins, Keith J.
T1  - THE OPPORTUNITIES AND RESPONSIBILITIES OF CLINICAL PSYCHOLOGY IN THE FIELD OF COMMUNITY SERVICES.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1950/04//
VL  - 6
IS  - 2
M3  - Article
SP  - 117
EP  - 121
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses the opportunities and responsibilities of clinical psychology in the field of community services. The clinical psychologist working in the traditional setting of the clinic or hospital is accustomed to having his cases brought to him in his own office where he usually works with them on an individual basis. Another way in which community work differs from work in the usual clinic setting is that the psychologist associates with different groups of workers. Most clinical psychologists have worked only with psychiatrists and social workers whose approach to problems is similar to theirs. Since other workers in the community often have rather vague concepts of the mental health specialties, they are apt to confuse their functions. If the psychologist is also confused, the situation will be all the more complicated.
KW  - CLINICAL psychology
KW  - PSYCHOLOGY
KW  - APPLIED psychology
KW  - MENTAL health personnel
KW  - MEDICAL personnel
KW  - PSYCHOLOGICAL tests
N1  - Accession Number: 15828813; Perkins, Keith J. 1; Affiliation:  1: Clinical Psychologist, Phoenix Mental Health Center, National Institute of Mental Health, U. S. P. H. S.; Source Info: Apr1950, Vol. 6 Issue 2, p117; Subject Term: CLINICAL psychology; Subject Term: PSYCHOLOGY; Subject Term: APPLIED psychology; Subject Term: MENTAL health personnel; Subject Term: MEDICAL personnel; Subject Term: PSYCHOLOGICAL tests; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shock, Nathan W.
T1  - GERONTOLOGY (LATER MATURITY).
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1951/02//
VL  - 2
IS  - 1
M3  - Article
SP  - 353
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11290999; Shock, Nathan W. 1; Affiliation:  1: National Heart Institute, National Institutes of Health; Source Info: 1951, Vol. 2 Issue 1, p353; Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bailey, Pearce
T1  - Relationship and Research and Education in a National Program for Handicapped Children.
JO  - Exceptional Children
JF  - Exceptional Children
Y1  - 1954/04//
VL  - 20
IS  - 7
M3  - Article
SP  - 289
EP  - 293
SN  - 00144029
AB  - The article discusses the relationship between research on neurological and sensory disorders and education of exceptional children. The growth of services for the exceptional child has been paralleled by the growth of research devoted to the prevention, diagnosis and treatment of the disorders which demand the services. The aim is to eliminate blindness, deafness, cerebral palsy, epilepsy and other disorders which create the exceptional child. Scientists are attempting to find the biological basis for functions such as perception, learning and memory. Research, education and rehabilitation may have an opportunity to work together.
KW  - EXCEPTIONAL children
KW  - SPECIAL education
KW  - MEDICAL research
KW  - DISABILITY evaluation
KW  - DIAGNOSIS
KW  - MEDICAL rehabilitation
KW  - SENSORY disorders in children
KW  - PERCEPTUAL disorders
KW  - COGNITIVE learning
N1  - Accession Number: 19788665; Bailey, Pearce 1; Affiliation:  1: Director of the National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, US Department of Health; Source Info: Apr1954, Vol. 20 Issue 7, p289; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: MEDICAL research; Subject Term: DISABILITY evaluation; Subject Term: DIAGNOSIS; Subject Term: MEDICAL rehabilitation; Subject Term: SENSORY disorders in children; Subject Term: PERCEPTUAL disorders; Subject Term: COGNITIVE learning; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Carlson, V. R.
T1  - Individual Differences in the Recall of Word-Association-Test Words.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1954/09//
VL  - 23
IS  - 1
M3  - Article
SP  - 77
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8946506; Carlson, V. R. 1; Affiliation:  1: National Institutes of Health, Institute of Mental Health, Bethesda, Maryland.; Source Info: Sep54, Vol. 23 Issue 1, p77; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1467-6494.ep8946506
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Radke-Yarrow, Marian
AU  - Yarrow, Leon J.
T1  - CHILD PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1955/02//
VL  - 6
IS  - 1
M3  - Article
SP  - 1
EP  - 28
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 17741202; Radke-Yarrow, Marian 1 Yarrow, Leon J. 2; Affiliation:  1: Laboratory of Socio-Environmental Studies, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.  2: Family and Child Services of Washington, D. C., Washington, D. C.; Source Info: 1955, Vol. 6 Issue 1, p1; Number of Pages: 28p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bayley, Nancy
T1  - INDIVIDUAL PATTERNS OF DEVELOPMENT.
JO  - Child Development
JF  - Child Development
Y1  - 1956/03//
VL  - 27
IS  - 1
M3  - Article
SP  - 45
EP  - 74
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12634131; Bayley, Nancy 1; Affiliation:  1: National Institute of Mental Health; Source Info: Mar1956, Vol. 27 Issue 1, p45; Number of Pages: 30p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Saslow, George
AU  - Goodrich, D. W.
AU  - Stein, Marvin
T1  - STUDY OF THERAPIST BEHAVIOR IN DIAGNOSTIC INTERVIEWS BY MEANS OF THE INTERACTION CHRONOGRAPH.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1956/04//
VL  - 12
IS  - 2
M3  - Article
SP  - 133
EP  - 139
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses the study of therapist behavior. An important aspect of the operation of clinics which evaluate the probable response of patients to behavior therapy is the diagnostic interview of the patient by an experienced staff member. An attempt is made in such an interview to decide various questions, such as the nature of the disabilities present, the need for further examinations or referrals, the wisdom of the referral to this particular clinic, the probable response of the patient to behavior therapy, the indicated major areas to work on in behavior therapy, the therapist most likely to be effective, etc.
KW  - PSYCHOTHERAPIST & patient
KW  - PSYCHOTHERAPY
KW  - BEHAVIOR modification
KW  - BEHAVIOR therapy
KW  - HEALTH facilities
KW  - DISABILITIES
N1  - Accession Number: 15845390; Saslow, George 1 Goodrich, D. W. 2 Stein, Marvin 3; Affiliation:  1: Massachusetts General Hospital and Harvard Medical School, University of Pennsylvania.  2: National Institute of Mental Health, University of Pennsylvania.  3: University of Pennsylvania.; Source Info: Apr1956, Vol. 12 Issue 2, p133; Subject Term: PSYCHOTHERAPIST & patient; Subject Term: PSYCHOTHERAPY; Subject Term: BEHAVIOR modification; Subject Term: BEHAVIOR therapy; Subject Term: HEALTH facilities; Subject Term: DISABILITIES; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Belleville, Richard E.
T1  - MMPI SCORE CHANGES INDUCED BY LYSERGIC ACID DIETHYLAMIDE (LSD-25).
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1956/07//
VL  - 12
IS  - 3
M3  - Article
SP  - 279
EP  - 282
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article investigates some of the psychological effects of Lysergic Acid Diethylamide (LSD-25) and evaluates the MMPI as an instrument for measuring personality changes produced by pharmaceutical agents. Twenty-four former narcotic addicts were given the MMPI under control, placebo and LSD conditions. The greatest increase following LSD was obtained on the Sc scale, since this scale measures the extent to which patients deviate from conventional ways of thinking and reacting and since the LSD syndrome has been compared frequently with schizophrenia.
KW  - LSD (Drug)
KW  - MINNESOTA Multiphasic Personality Inventory
KW  - PERSONALITY tests
KW  - DRUG addicts
KW  - PLACEBOS (Medicine)
KW  - SCHIZOPHRENIA
N1  - Accession Number: 15845482; Belleville, Richard E. 1; Affiliation:  1: The National Institute of Mental Health Addiction Research Center, USPHS Hospital Lexington, Kentucky.; Source Info: Jul1956, Vol. 12 Issue 3, p279; Subject Term: LSD (Drug); Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: PERSONALITY tests; Subject Term: DRUG addicts; Subject Term: PLACEBOS (Medicine); Subject Term: SCHIZOPHRENIA; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gewirtz, Jacob L.
AU  - Baer, Donald M.
AU  - Roth, Chaya H.
T1  - A NOTE ON THE SIMILAR EFFECTS OF LOW SOCIAL AVAILABILITY OF AN ADULT AND BRIEF SOCIAL DEPRIVATION ON YOUNG CHILDREN'S BEHAVIOR.
JO  - Child Development
JF  - Child Development
Y1  - 1958/03//
VL  - 29
IS  - 1
M3  - Article
SP  - 149
EP  - 152
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12279985; Gewirtz, Jacob L. 1 Baer, Donald M. 2 Roth, Chaya H. 3; Affiliation:  1: Laboratory of Psychology, National Institute of Mental Health  2: University of Washington  3: University of Chicago; Source Info: Mar1958, Vol. 29 Issue 1, p149; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosvold, H.Enger
T1  - PHYSIOLOGICAL PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1959/02//
VL  - 10
IS  - 1
M3  - Article
SP  - 415
EP  - 454
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11290181; Rosvold, H.Enger 1; Affiliation:  1: Laboratory of  Psychology,  National Institute of Mental Health Bethesda, Maryland.; Source Info: 1959, Vol. 10 Issue 1, p415; Number of Pages: 40p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jacobson, Stanley
AU  - Faegre, Christopher
T1  - NEUTRALIZATION: A Tool for the teacher of DISTURBED CHILDREN.
JO  - Exceptional Children
JF  - Exceptional Children
Y1  - 1959/02//
VL  - 25
IS  - 6
M3  - Article
SP  - 243
EP  - 246
SN  - 00144029
AB  - The article considers the concept of neutralization as a useful tool for teachers of disturbed children. Neutralization means freeing the child's area of problem that depends on those personality characteristics in which he happens to be weakest. The schools are planning for disturbed children by providing special counseling and referral services. It is suggested that neutralization can be considered an additional classroom tool to minimize the influence of personality problems on the learning process of disturbed children.
KW  - MENTALLY ill children -- Education
KW  - PERSONALITY in children
KW  - TEACHING aids & devices
KW  - EXCEPTIONAL children
KW  - SPECIAL education
KW  - LEARNING
KW  - CHILDREN -- Services for
KW  - TEACHERS
KW  - EDUCATIONAL programs
KW  - EDUCATIONAL standards
N1  - Accession Number: 19807885; Jacobson, Stanley 1 Faegre, Christopher 2; Affiliation:  1: Educational specialist, Child Research Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland  2: Teacher, Remedial Child Research Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; Source Info: Feb1959, Vol. 25 Issue 6, p243; Subject Term: MENTALLY ill children -- Education; Subject Term: PERSONALITY in children; Subject Term: TEACHING aids & devices; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: LEARNING; Subject Term: CHILDREN -- Services for; Subject Term: TEACHERS; Subject Term: EDUCATIONAL programs; Subject Term: EDUCATIONAL standards; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Little, Kenneth B.
T1  - Connotations of the Rorschach inkblots.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1959/09//
VL  - 27
IS  - 3
M3  - Article
SP  - 397
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8946421; Little, Kenneth B. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Sep59, Vol. 27 Issue 3, p397; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1467-6494.ep8946421
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Haertzen, Charles A.
AU  - Hill, Harris E.
T1  - EFFECTS OF MORPHINE AND PENTOBARBITAL ON DIFFERENTIAL MMPI PROFILES.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1959/10//
VL  - 15
IS  - 4
M3  - Article
SP  - 434
EP  - 437
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses the effects of morphine and pentobarbital on differential MMPI profiles. Evidence that altering certain incentives modifies the behavioral effects of morphine and pentobarbital was presented in a previous report. The present study was similar in formulation but was specifically concerned with possible core relations between drug effects and personality characteristics as measured by the MMPI. That this inventory may be useful in assessing drug effects has been demonstrated. No mention was made in these reports of a possible interaction between personality and drug effect.
KW  - DRUGS -- Physiological effect
KW  - MORPHINE
KW  - PENTOBARBITAL
KW  - PERSONALITY
KW  - INVENTORIES
KW  - DRUGS -- Effectiveness
N1  - Accession Number: 15847207; Haertzen, Charles A. 1 Hill, Harris E. 1; Affiliation:  1: National Institute of Mental Health, Addiction Research Center, PHS, Lexington, Kentucky.; Source Info: Oct1959, Vol. 15 Issue 4, p434; Subject Term: DRUGS -- Physiological effect; Subject Term: MORPHINE; Subject Term: PENTOBARBITAL; Subject Term: PERSONALITY; Subject Term: INVENTORIES; Subject Term: DRUGS -- Effectiveness; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Birren, James E.
T1  - PSYCHOLOGICAL ASPECTS OF AGING.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1960/02//
VL  - 11
IS  - 1
M3  - Article
SP  - 161
EP  - 198
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11266867; Birren, James E. 1; Affiliation:  1: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Source Info: 1960, Vol. 11 Issue 1, p161; Number of Pages: 38p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rubenstein, Herbert
AU  - Aborn, Murray
T1  - PSYCHOLINGUISTICS.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1960/02//
VL  - 11
IS  - 1
M3  - Article
SP  - 291
EP  - 322
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11267426; Rubenstein, Herbert 1 Aborn, Murray 2; Affiliation:  1: Operational Applications Laboratory, Air Forte Cambridge Research Center, Bedford, Massachusetts.  2: Division of Research Grants, National  Institutes of Health, Bethesda, Maryland.; Source Info: 1960, Vol. 11 Issue 1, p291; Number of Pages: 32p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ross, Sherman
AU  - Cole, Jonathan 0.
T1  - PSYCHOPHARMACOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1960/02//
VL  - 11
IS  - 1
M3  - Article
SP  - 415
EP  - 438
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11267444; Ross, Sherman 1 Cole, Jonathan 0. 2; Affiliation:  1: University of  Maryland, College Park, Maryland.  2: Psychopharmacology Service center, National  Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Source Info: 1960, Vol. 11 Issue 1, p415; Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenthal, David
AU  - Lawlor, William G.
AU  - Zahn, Theodore P.
AU  - Shakow, David
T1  - The relationship of some aspects of mental set to degree of schizophrenic disorganization.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1960/03//
VL  - 28
IS  - 1
M3  - Article
SP  - 26
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8931052; Rosenthal, David 1 Lawlor, William G. 1,2 Zahn, Theodore P. 1 Shakow, David 1; Affiliation:  1: Laboratory of Psychology, National Institute of Mental Health.  2: Assistant Professor of Psychology, Fordham University.; Source Info: Mar60, Vol. 28 Issue 1, p26; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1467-6494.ep8931052
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Williams, Richard H.
T1  - Mental Health Manpower Trends (Book).
JO  - Journal of Health & Human Behavior
JF  - Journal of Health & Human Behavior
Y1  - 1960///Summer1960
VL  - 1
IS  - 2
M3  - Book Review
SP  - 142
EP  - 143
SN  - 00959006
AB  - Reviews the book "Mental Health Manpower Trends," by George W. Albee.
KW  - MENTAL health
KW  - NONFICTION
KW  - ALBEE, George W.
KW  - MENTAL Health Manpower Trends: A Report to the Staff Director, Jack R. Ewalt: 1959 (Book)
N1  - Accession Number: 15444107; Williams, Richard H. 1; Affiliation:  1: National Institute of Mental Health; Source Info: Summer1960, Vol. 1 Issue 2, p142; Subject Term: MENTAL health; Subject Term: NONFICTION; Reviews & Products: MENTAL Health Manpower Trends: A Report to the Staff Director, Jack R. Ewalt: 1959 (Book); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); People: ALBEE, George W.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bell, Richard Q.
T1  - RELATIONS BETWEEN BEHAVIOR MANIFESTATIONS IN THE HUMAN NEONATE.
JO  - Child Development
JF  - Child Development
Y1  - 1960/09//
VL  - 31
IS  - 3
M3  - Article
SP  - 463
EP  - 477
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 16288998; Bell, Richard Q. 1; Affiliation:  1: Laboratory of Psychology, National Institute of Mental Health, National Institute of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda 14, Maryland; Source Info: Sep1960, Vol. 31 Issue 3, p463; Number of Pages: 15p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rheingold, Harriet L.
T1  - THE MEASUREMENT OF MATERNAL CARE.
JO  - Child Development
JF  - Child Development
Y1  - 1960/09//
VL  - 31
IS  - 3
M3  - Article
SP  - 565
EP  - 575
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 16289075; Rheingold, Harriet L. 1; Affiliation:  1: National Institute of Mental Health; Source Info: Sep1960, Vol. 31 Issue 3, p565; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Syme, S. Leonard
T1  - Thirty Years of Research in Human Fertility -- Retrospect and Prospect (Book).
JO  - Journal of Health & Human Behavior
JF  - Journal of Health & Human Behavior
Y1  - 1960///Winter1960
VL  - 1
IS  - 4
M3  - Book Review
SP  - 321
EP  - 322
SN  - 00959006
AB  - Reviews the book "Thirty Years of Research in Human Fertility: Retrospect and Prospect."
KW  - FERTILITY
KW  - NONFICTION
KW  - 30 Years of Research in Human Fertility: Retrospect & Prospect (Book)
N1  - Accession Number: 15176986; Syme, S. Leonard 1; Affiliation:  1: National Institutes of Health.; Source Info: Winter1960, Vol. 1 Issue 4, p321; Subject Term: FERTILITY; Subject Term: NONFICTION; Reviews & Products: 30 Years of Research in Human Fertility: Retrospect & Prospect (Book); Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Suster, E.
AU  - Kirsanow, Eugene M.
T1  - Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions.
JO  - Immunology
JF  - Immunology
Y1  - 1961/10//
VL  - 4
IS  - 4
M3  - Article
SP  - 354
EP  - 365
PB  - Wiley-Blackwell
SN  - 00192805
AB  - In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms. Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37RV or Vallée. The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDOTOXINS
KW  - IMMUNE response
KW  - MYCOBACTERIA
KW  - BACTERIAL toxins
KW  - ANTIGEN-antibody reactions
KW  - MICE as carriers of disease
KW  - IMMUNOLOGY
N1  - Accession Number: 12534120; Suster, E. 1,2 Kirsanow, Eugene M. 1,2; Affiliation:  1: Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida, U.S.A.  2: National Institute of Allergy and Infectious Diseases, National Institute of Health, United States Public Health Service; Source Info: Oct61, Vol. 4 Issue 4, p354; Subject Term: ENDOTOXINS; Subject Term: IMMUNE response; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL toxins; Subject Term: ANTIGEN-antibody reactions; Subject Term: MICE as carriers of disease; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cromwell, Rue L.
AU  - Rosenthal, David
AU  - Shakow, David
AU  - Zahn, Theodore P.
T1  - Reaction time, locus of control, choice behavior, and descriptions of parental behavior in schizophrenic and normal subjects.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1961/12//
VL  - 29
IS  - 4
M3  - Article
SP  - 363
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8933354; Cromwell, Rue L. 1 Rosenthal, David 2 Shakow, David 2 Zahn, Theodore P. 2; Affiliation:  1: George Peabody College for Teachers.  2: National Institute of Mental Health.; Source Info: Dec61, Vol. 29 Issue 4, p363; Number of Pages: 17p; Document Type: Article
L3  - 10.1111/1467-6494.ep8933354
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Manne, Sigmund H.
AU  - Kandel, Arthur
AU  - Rosenthal, David
T1  - DIFFERENCES BETWEEN PERFORMANCE IQ AND VERBAL IQ IN A SEVERELY SOCIOPATHIC POPULATION.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1962/01//
VL  - 18
IS  - 1
M3  - Article
SP  - 73
EP  - 77
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article reports that studies of the relationship between Performance IQ and Verbal IQ in the sociopath have resulted in contradictory findings. The operational definition of sociopath used was a behavioral one: the experimental subjects were a group of 112 sex offenders all of whom, at the time of examination, already had been convicted in a court of sexual crime against another person sent to the Oregon State Hospital for psychiatric and psychological examination. Ss were 193 defective delinquents committed to Maryland's Patuxent Institution for diagnosis and treatment.
KW  - INTELLIGENCE levels
KW  - ANTISOCIAL personality disorders
KW  - PERSONALITY disorders
KW  - ANTINOMIAN personality
KW  - PUBLIC hospitals
KW  - OREGON
N1  - Accession Number: 15828168; Manne, Sigmund H. 1 Kandel, Arthur 1 Rosenthal, David 2; Affiliation:  1: Patuxent Institution, Jessup, Maryland.  2: National Institute of Mental Health.; Source Info: Jan1962, Vol. 18 Issue 1, p73; Subject Term: INTELLIGENCE levels; Subject Term: ANTISOCIAL personality disorders; Subject Term: PERSONALITY disorders; Subject Term: ANTINOMIAN personality; Subject Term: PUBLIC hospitals; Subject Term: OREGON; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hollister, William C.
AU  - Coldston, Stephen E.
T1  - Psychoeducational Processes in Classes for Emotionally Handicapped Children.
JO  - Exceptional Children
JF  - Exceptional Children
Y1  - 1962/03//
VL  - 28
IS  - 7
M3  - Article
SP  - 351
EP  - 356
SN  - 00144029
AB  - The article evaluates the psychoeducational processes in classes for emotionally handicapped children. The authors reviewed and analyzed a sample of program description from schools in the U.S. that are currently giving classes for emotionally handicapped children, and gathered the data from existing reports into a beginning taxonomy of the procedures and considerations involved in conducting classes for emotionally handicapped children. In this article, the researchers found that there is a need for some elderly classification of the various psychoeducational processes.
KW  - CHILDREN with disabilities -- Education
KW  - EXCEPTIONAL children
KW  - SPECIAL education
KW  - CHILD psychology
KW  - CHILD development
KW  - MENTAL health
KW  - PSYCHOLOGY of learning
KW  - EDUCATION -- United States
KW  - UNITED States
N1  - Accession Number: 19680994; Hollister, William C. 1 Coldston, Stephen E. 2; Affiliation:  1: Consultant, Mental Health in Education, Community Services Branch, National Institute of Mental Health, Bethesda  2: Chief, Mental Health Education Unit of the New York City Community Mental Health Board, New York; Source Info: Mar1962, Vol. 28 Issue 7, p351; Subject Term: CHILDREN with disabilities -- Education; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: CHILD psychology; Subject Term: CHILD development; Subject Term: MENTAL health; Subject Term: PSYCHOLOGY of learning; Subject Term: EDUCATION -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
AU  - Scarr, Sandra
T1  - Affiliation among chronic schizophrenics: relation to intrapersonal and birth order factors.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1962/06//
VL  - 30
IS  - 2
M3  - Article
SP  - 178
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8932610; Schooler, Carmi 1 Scarr, Sandra 2; Affiliation:  1: National Institute of Mental Health.  2: Radcliffe College.; Source Info: Jun62, Vol. 30 Issue 2, p178; Number of Pages: 15p; Document Type: Article
L3  - 10.1111/1467-6494.ep8932610
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bower, Eli M.
T1  - The Role of Schools in Mental Health.
JO  - Exceptional Children
JF  - Exceptional Children
Y1  - 1962/12//
VL  - 29
IS  - 4
M3  - Book Review
SP  - 197
EP  - 198
SN  - 00144029
AB  - The article reviews the book "The Role of Schools in Mental Health," by Wesley Allinsmith and George W. Goethals.
KW  - MENTAL health education
KW  - NONFICTION
KW  - ALLINSMITH, Wesley
KW  - GOETHALS, George W. (George Washington), 1858-1928
KW  - ROLE of Schools in Mental Health, The (Book)
N1  - Accession Number: 19707003; Bower, Eli M. 1; Affiliation:  1: Consultant, Mental Health in Education, Community Services Branch, National Institute of Mental Health, Bethesda, Maryland; Source Info: Dec1962, Vol. 29 Issue 4, p197; Subject Term: MENTAL health education; Subject Term: NONFICTION; Reviews & Products: ROLE of Schools in Mental Health, The (Book); People: ALLINSMITH, Wesley; People: GOETHALS, George W. (George Washington), 1858-1928; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Manne, Sigmund H.
AU  - Kandel, Arthur
AU  - Rosenthal, David
T1  - THE RELATIONSHIP BETWEEN PERFORMANCE MINUS VERBAL SCORES AND EXTRAVERSION IN A SEVERELY SOCIOPATHIC POPULATION.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1963/01//
VL  - 19
IS  - 1
M3  - Article
SP  - 96
EP  - 97
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article presents the relationship between performance intelligence quotient (IQ) minus verbal IQ scores and extraversion in a severely sociopathic population. One hundred inmates who had been admitted to the Patuxent Institution were given the Maudsley Personality Inventory, which is designed to measure two orthogonal factors: Extraversion-Introversion and Neuroticism. The Wechsler-Bellevue Intelligence Scale, Form I, is given routinely to all new admissions to Patuxent Institution as part of the diagnostic evaluation. The negative correlation barely misses significance at the .05 levels, and is in the opposite direction from the one predicted by the hypothesis.
KW  - ANTISOCIAL personality disorders
KW  - INTELLIGENCE levels
KW  - WECHSLER Adult Intelligence Scale
KW  - PERSONALITY tests
KW  - MAUDSLEY personality inventory
KW  - EXTRAVERSION
KW  - INTROVERSION
N1  - Accession Number: 15844061; Manne, Sigmund H. 1 Kandel, Arthur 1 Rosenthal, David 2; Affiliation:  1: Patuxent Institution, Jessup, Maryland.  2: National Institute of Mental Health.; Source Info: Jan1963, Vol. 19 Issue 1, p96; Subject Term: ANTISOCIAL personality disorders; Subject Term: INTELLIGENCE levels; Subject Term: WECHSLER Adult Intelligence Scale; Subject Term: PERSONALITY tests; Subject Term: MAUDSLEY personality inventory; Subject Term: EXTRAVERSION; Subject Term: INTROVERSION; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rheingold, Harriet L.
AU  - Stanley, Walter C.
T1  - DEVELOPMENTAL PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1963/02//
VL  - 14
IS  - 1
M3  - Article
SP  - 1
EP  - 28
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 32898265; Rheingold, Harriet L. 1 Stanley, Walter C. 1; Affiliation:  1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Source Info: 1963, Vol. 14 Issue 1, p1; Number of Pages: 28p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Harris, T.N.
AU  - Dray, Sheldon
AU  - Ellsworth, Barbara
AU  - Harris, Susanna
T1  - Rabbit Gamma-Globulin Allotypes as Genetic Markers for the Source of Antibody Produced in Recipients of <em>Shigella</em>-Incubated Lymph Node Cells.
JO  - Immunology
JF  - Immunology
Y1  - 1963/03//
VL  - 6
IS  - 2
M3  - Article
SP  - 169
EP  - 178
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Rabbits homozygous for each of an allelic pair of allotypes of γ globulin (A4 and A5) were used as donors and recipients of transferred antigen-incubated lymph node cells, the cells of donors of one allotype being in each case transferred to recipients of the other. When agglutinins to Shigella (the source of the antigen with which the lymph node dells were incubated) appeared in the sera of the recipient animals, the allotype of the agglutinin was determined by adsorbing it to Shigella on a glass slide, then treating the preparations with fluorescein-conjugated rabbit anti-A5-γ-globulin and anti-A4-γ-globulin antisera, respectively. In each case the reactions of the recipients' sera were positive for γ globulin of the donors' allotype but not of their own. Positive reactions were given only by sera above a certain range of agglutinin titre. After sufficient decline of the agglutinin level in the sera of the recipients, these animals were actively immunized with Shigella. The agglutinins that now appeared in these rabbits gave positive reactions with the fluorescent antibody against their own allotype. These data indicated that in moderately X-irradiated rabbits given antigen-incubated rabbit lymph node cells, the antibody that subsequently appears in the recipient's serum has been synthesized by the donor's cells. These experiments also illustrate the use of allotypes as genetic markers in lymph node cell transfer experiments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GAMMA globulins
KW  - GENETIC markers
KW  - LYMPH nodes
KW  - IMMUNOGLOBULIN allotypes
KW  - IMMUNOGENETICS
KW  - IMMUNOLOGY
N1  - Accession Number: 12673789; Harris, T.N. 1 Dray, Sheldon 1 Ellsworth, Barbara 1 Harris, Susanna 1; Affiliation:  1: Children's Hospital of Philadelphia (Department of Pediatrics, School of Medicine, University of Pennsylvania), Laboratory of Immunology, National Institute of Allergy and Infectious Diseases; Source Info: Mar63, Vol. 6 Issue 2, p169; Subject Term: GAMMA globulins; Subject Term: GENETIC markers; Subject Term: LYMPH nodes; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: IMMUNOGENETICS; Subject Term: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Haertzen, Charles A.
AU  - Hill, Harris E.
T1  - ASSESSING SUBJECTIVE EFFECTS OF DRUGS: AN INDEX OF CARELESSNESS AND CONFUSION FOR USE WITH THE ADDICTION RESEARCH CENTER INVENTORY (ARCI).
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1963/10//
VL  - 19
IS  - 4
M3  - Article
SP  - 407
EP  - 412
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article presents information on a study conducted to determine the subjective effects of drugs. The data presented in the study were collected from the Addiction Research Center Inventory. A need to establish some reliability became necessary because the inventory could be used several times by the same subjects. The data was used to evaluate illiteracy, carelessness and drug-induced confusion while administering drugs to patients.
KW  - DRUGS -- Effectiveness
KW  - RESEARCH institutes
KW  - DRUGS -- Physiological effect
KW  - TESTING
KW  - LITERACY
KW  - PATIENTS
KW  - ADDICTION Research Center (U.S.)
N1  - Accession Number: 16763512; Haertzen, Charles A. 1 Hill, Harris E. 1; Affiliation:  1: National Institute of Mental Health, Addiction Research Center PHS Hospital, Lexington, Kentucky.; Source Info: Oct1963, Vol. 19 Issue 4, p407; Subject Term: DRUGS -- Effectiveness; Subject Term: RESEARCH institutes; Subject Term: DRUGS -- Physiological effect; Subject Term: TESTING; Subject Term: LITERACY; Subject Term: PATIENTS; Company/Entity: ADDICTION Research Center (U.S.); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Erlich, Howard J.
T1  - These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations.
JO  - Sociological Quarterly
JF  - Sociological Quarterly
Y1  - 1964///Spring64
VL  - 5
IS  - 2
M3  - Book Review
SP  - 177
EP  - 178
SN  - 00380253
AB  - Reviews the book "These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations," by Jacqueline J. Clarke.
KW  - CIVIL rights organizations
KW  - NONFICTION
KW  - CLARKE, Jacqueline J.
KW  - THESE Rights They Seek (Book)
N1  - Accession Number: 14021169; Erlich, Howard J. 1; Affiliation:  1: National Institute of Mental Health; Source Info: Spring64, Vol. 5 Issue 2, p177; Subject Term: CIVIL rights organizations; Subject Term: NONFICTION; Reviews & Products: THESE Rights They Seek (Book); NAICS/Industry Codes: 813310 Social advocacy organizations; NAICS/Industry Codes: 813311 Human Rights Organizations; People: CLARKE, Jacqueline J.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simmons, William L.
AU  - Tyler, Forrest B.
T1  - A COMPARISON OF PATIENT AND STAFF CONCEPTIONS OF THERAPISTS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1964/10//
VL  - 20
IS  - 4
M3  - Article
SP  - 508
EP  - 512
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article measures staff perceptions, however, the emphasis professional disciplines can predict perceptions and compares them with patient is on determining whether members of various how they are seen by patients. The subjects consisted of 19 volunteers from the professional staff working on a ward on which patient data were gathered at the Anna State Hospital, Anna, Illinois, between December, 1961, and August, 1962. The comparison of staff and patient usage of each category for each discipline reveals some very striking differences. It appears that staff personnel conceptualize therapeutic disciplines primarily in terms of the nature of their skills, duties, or professional identification, or of some evaluation of these task related activities.
KW  - PHYSICIAN & patient
KW  - INTERPERSONAL relations
KW  - MEDICAL personnel & patient
KW  - VOLUNTEER service
KW  - PUBLIC hospitals
KW  - ILLINOIS
N1  - Accession Number: 15844215; Simmons, William L. 1 Tyler, Forrest B. 2; Affiliation:  1: University of Arizona  2: National Institute of Mental Health; Source Info: Oct1964, Vol. 20 Issue 4, p508; Subject Term: PHYSICIAN & patient; Subject Term: INTERPERSONAL relations; Subject Term: MEDICAL personnel & patient; Subject Term: VOLUNTEER service; Subject Term: PUBLIC hospitals; Subject Term: ILLINOIS; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Alderman, Michael H.
T1  - Why We Need Medicare.
JO  - New Republic
JF  - New Republic
Y1  - 1964/12/26/
VL  - 151
IS  - 26
M3  - Article
SP  - 17
EP  - 20
SN  - 00286583
AB  - Calls for the U.S. government to recognize medical care for the aged as a national obligation as of 1964.  Results of the vague and permissive guidelines established by Congress; Provisions of the Social Security Act of 1960; Weaknesses produced by the state implementation of medical care programs under the Act; Examples of exclusions and limitations that curtail the value of private insurance; Objections of the American Medical Association to Medicare.
KW  - MEDICAL care -- United States
KW  - MEDICAL care for the aged
KW  - SOCIAL security -- Law & legislation
KW  - MEDICARE
KW  - HEALTH insurance -- United States
KW  - UNITED States
N1  - Accession Number: 10013939; Alderman, Michael H. 1; Affiliation:  1: US Public Health Service, National Institutes of Health, Bethesda, Maryland; Source Info: 12/26/64, Vol. 151 Issue 26, p17; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care for the aged; Subject Term: SOCIAL security -- Law & legislation; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Surwillo, Walter W.
AU  - Quilter, Reginald E.
T1  - THE RELATION OF FREQUENCY OF SPONTANEOUS SKIN POTENTIAL RESPONSES TO VIGILANCE AND TO AGE.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1965/01//
VL  - 1
IS  - 3
M3  - Article
SP  - 272
EP  - 276
SN  - 00485772
AB  - Skin potential (Tarchanoff effect) was recorded in 132 healthy males, aged 22 to 85 years. while they performed an hour-long watchkeeping task. Vigilance level, as measured by S's detection or failure to detect certain critical stimuli, proved to be related to frequency of spontaneous skin potential responses (SPRs) in an interval immediately preceding the stimulus. Low vigilance was associated with fewer spontaneous SPRs per unit of time than high vigilance. This relationship did not appear to be the result of a correlation of the physiological and behavioral variables with time or with age. Old persons evinced a smaller number of spontaneous SPRs in a standard time interval than young persons. Lacey and Lacey's hypothesis that autonomic "labiles," or Ss who show a large number of spontaneous autonomic responses, have shorter reaction times than autonomic "stabiles" was confirmed. A related hypothesis. in which number of erroneous motor responses was the dependent variable. was not substantiated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GALVANIC skin response
KW  - VIGILANCE (Psychology)
KW  - SIGNAL detection (Psychology)
KW  - CONDITIONED response
KW  - MALES
KW  - BEHAVIORISM (Psychology)
KW  - AGE
KW  - Aging.
KW  - Autonomic
KW  - Skin Potential
KW  - Spontaneous SPR
KW  - Tarchanoff effect
KW  - Vigilance
KW  - Watchkeeping
N1  - Accession Number: 11044659; Surwillo, Walter W. 1 Quilter, Reginald E. 1; Affiliation:  1: National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.; Source Info: Jan1965, Vol. 1 Issue 3, p272; Subject Term: GALVANIC skin response; Subject Term: VIGILANCE (Psychology); Subject Term: SIGNAL detection (Psychology); Subject Term: CONDITIONED response; Subject Term: MALES; Subject Term: BEHAVIORISM (Psychology); Subject Term: AGE; Author-Supplied Keyword: Aging.; Author-Supplied Keyword: Autonomic; Author-Supplied Keyword: Skin Potential; Author-Supplied Keyword: Spontaneous SPR; Author-Supplied Keyword: Tarchanoff effect; Author-Supplied Keyword: Vigilance; Author-Supplied Keyword: Watchkeeping; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bell, Richard Q.
T1  - DEVELOPMENTAL PSYCHOLOGY.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1965/02//
VL  - 16
IS  - 1
M3  - Article
SP  - 1
EP  - 38
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11301340; Bell, Richard Q. 1; Affiliation:  1: Child Research Branch, National Institute of Mental Health; Source Info: 1965, Vol. 16 Issue 1, p1; Number of Pages: 38p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schaefer, Earl S.
T1  - DOES THE SAMPLING METHOD PRODUCE THE NEGATIVE CORRELATION OF MEAN IQ WITH AGE REPORTED BY KENNEDY, VAN DE RIET, AND WHITE?
JO  - Child Development
JF  - Child Development
Y1  - 1965/03//
VL  - 36
IS  - 1
M3  - Article
SP  - 257
EP  - 259
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12083521; Schaefer, Earl S. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Mar1965, Vol. 36 Issue 1, p257; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Surwillo, Walter W.
AU  - Arenberg, David L.
T1  - ON THE LAW OF INITIAL VALUE AND THE MEASUREMENT OF CHANGE.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1965/04//
VL  - 1
IS  - 4
M3  - Article
SP  - 368
EP  - 370
SN  - 00485772
AB  - The article demonstrates the variable change measurements and the application of law of initial value (LIV) test in the study of autonomic variables in every individual within the experimental groups. The measurements on the changes without an intervening stimulus was presented using the criterion on pre-stimulus and post-stimulus values of variables by D. J. Hord, L. C. Johnson and A. Lubin. The LIV was demonstrated by using the heart rate data collected from the group when doing a simple reaction task.
KW  - HEART beat
KW  - INITIAL value problems
KW  - NUMERICAL analysis
KW  - CARDIAC contraction
KW  - CRITERION referenced tests
N1  - Accession Number: 19001963; Surwillo, Walter W. 1 Arenberg, David L. 1; Affiliation:  1: National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; Source Info: Apr1965, Vol. 1 Issue 4, p368; Subject Term: HEART beat; Subject Term: INITIAL value problems; Subject Term: NUMERICAL analysis; Subject Term: CARDIAC contraction; Subject Term: CRITERION referenced tests; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bayley, Nancy
T1  - COMPARISONS OF MENTAL AND MOTOR TEST SCORES FOR AGES 1-15 MONTHS BY SEX, BIRTH ORDER, RACE, GEOGRAPHICAL LOCATION, AND EDUCATION OF PARENTS.
JO  - Child Development
JF  - Child Development
Y1  - 1965/06//
VL  - 36
IS  - 2
M3  - Article
SP  - 379
EP  - 411
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12084360; Bayley, Nancy 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1965, Vol. 36 Issue 2, p379; Number of Pages: 33p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schaefer, Earl S.
T1  - CHILDREN'S REPORTS OF PARENTAL BEHAVIOR: AN INVENTORY.
JO  - Child Development
JF  - Child Development
Y1  - 1965/06//
VL  - 36
IS  - 2
M3  - Article
SP  - 413
EP  - 424
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12084370; Schaefer, Earl S. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1965, Vol. 36 Issue 2, p413; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Boomer, Donald S.
T1  - HESITATION AND GRAMMATICAL ENCODING.
JO  - Language & Speech
JF  - Language & Speech
Y1  - 1965/07//Jul-Sep65
VL  - 8
IS  - 3
M3  - Article
SP  - 148
EP  - 158
PB  - Sage Publications, Ltd.
SN  - 00238309
AB  - The article focuses on a study that concerns in the occurrence of filled and unfilled pauses of hesitations with respect to their location in phonemic clauses in spontaneous English speech. Both types of hesitation were most frequent after the first word in the clause, regardless of length. In this study, the data to be presented concern the location of these hesitations in extended utterances, but the basic theoretical issue involved is the nature of the grammatical encoding process in speech. These data are regarded as directly challenging the transitional probability theory of hesitations. In addition, the phonemic clause is proposed as the encoding unit of speech at the grammatical level.
KW  - SPEECH -- Study & teaching
KW  - LANGUAGE & languages -- Study & teaching
KW  - ENGLISH language -- Study & teaching
KW  - HESITATION form (Linguistics)
KW  - CLAUSES (Grammar)
KW  - JUNCTURE (Linguistics)
KW  - LINGUISTICS
KW  - PHONETICS
KW  - PHONOLOGICAL encoding
N1  - Accession Number: 21832518; Boomer, Donald S. 1,2; Affiliation:  1: National Institute of Mental Health, Bethesda  2: Laboratory of Psychology, National Institute of Mental Health, National Institutes of Health, Department of Health, Education and Welfare; Source Info: Jul-Sep65, Vol. 8 Issue 3, p148; Subject Term: SPEECH -- Study & teaching; Subject Term: LANGUAGE & languages -- Study & teaching; Subject Term: ENGLISH language -- Study & teaching; Subject Term: HESITATION form (Linguistics); Subject Term: CLAUSES (Grammar); Subject Term: JUNCTURE (Linguistics); Subject Term: LINGUISTICS; Subject Term: PHONETICS; Subject Term: PHONOLOGICAL encoding; NAICS/Industry Codes: 611630 Language Schools; Number of Pages: 11p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Asheron, G. L.
AU  - Stone, S. H.
T1  - Selective and Specific Inhibition of 24 Hour Skin Reactions in the Guinea-Pig I. IMMUNE DEVIATION: DESCRIPTION OF THE PHENOMENON AND THE EFFECT OF SPENECTOMY.
JO  - Immunology
JF  - Immunology
Y1  - 1965/09//
VL  - 9
IS  - 3
M3  - Article
SP  - 205
EP  - 217
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Strong 24 hour skin reactions occur in guinea-pigs immunized with antigen in Freund's complete adjuvant. These reactions were reduced by the injection of 1 mg of the same antigen, in either the soluble or alum precipitated form, 14 days before immunization with antigen in Freund's complete adjuvant. There was also a reduction in the corneal reaction, which has been regarded as an index of delayed hypersensitivity. This phenomenon was called immune deviation. The phenomenon was demonstrated for bovine γ-globulin, human serum albumin, bovine serum albumin, egg albumin, diptheria toxoid, hacmocyanin, purified protein derivative (PPD) and dinitrophenylated proteins. Ten mg of soluble bovine γ-globulin caused considerable reduction of the circulating antibody level and of the 24 hour skin reaction. Alum precipitated bovine γ-globulin and smaller doses of soluble antigen reduced the skin reaction but had less effect on the antibody level. Similar results were obtained with human serum albumin. This suggested that the conditions for eliciting immune paralysis and immune deviation were different. Immune deviation was obtained with either footpad or intravenous injections and with as little as 100 µg of antigen. Alum precipitated bovine γ-globulin caused immune deviation when given 14, 7 or 1 day before or 1 day after immunization with antigen in Freund's complete adjuvant. It was inactive when given 6 days after immunization. Splenectomy had no effect on the production or deviation of 24 hour skin reactions. Alum precipitated antigen had a variable and usually slight effect on the level of antibody following immunization with the same antigen in Freund's complete adjuvant. There was, however, a qualitative alteration in the antibody. The sera of guinea-pigs, which had been deviated by a prior injection of bovine serum albumin or bovine γ-globulin, showed only a gamma;1 line of antibody on immunoelectrophoresis, while the sera of control guinea-pigs also showed the γ2 line characteristically seen in guinea-pigs immunized with antigen in Freund's complete adjuvant. It was concluded that immune deviation was distinct from classical immune paralysis and that the immunologically specific reduction of the 24 hour skin reactions might be due, at least in part, to a selective loss of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNIZATION
KW  - ANTIGENS
KW  - DELAYED hypersensitivity
KW  - GLOBULINS
KW  - ALBUMINS
KW  - PROTEINS
KW  - IMMUNOGLOBULINS
KW  - ALUM
KW  - SPLENECTOMY
KW  - ANIMAL models in research
N1  - Accession Number: 13279305; Asheron, G. L. 1 Stone, S. H. 2; Affiliation:  1: National Institute for Medical Research, Mill Hill, London, England  2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.; Source Info: Sep65, Vol. 9 Issue 3, p205; Subject Term: IMMUNIZATION; Subject Term: ANTIGENS; Subject Term: DELAYED hypersensitivity; Subject Term: GLOBULINS; Subject Term: ALBUMINS; Subject Term: PROTEINS; Subject Term: IMMUNOGLOBULINS; Subject Term: ALUM; Subject Term: SPLENECTOMY; Subject Term: ANIMAL models in research; NAICS/Industry Codes: 212391 Potash, Soda, and Borate Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Berger, Ralph J.
AU  - Meier, Gilbert W.
T1  - AN AUTOMATIC ANALYZER OF STATES OF VIGILANCE.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1965/10//
VL  - 2
IS  - 2
M3  - Article
SP  - 141
EP  - 145
SN  - 00485772
AB  - An assemblage of relay-operated, commercially available programming modules is described. It is capable of discriminating among the states of vigilance - wakefulness (W); high-voltage, slow-wave sleep (HVS); and low-voltage, fast-wave sleep (LVF) - and it requires information from only the nuchal electromyogram (EMG) and the electrooculogram (EOG). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEURAL analyzers
KW  - SLEEP
KW  - VIGILANCE (Psychology)
KW  - CENTRAL nervous system
KW  - SLEEP-wake cycle
KW  - DREAMS
KW  - Analyzer
KW  - Dreaming.
KW  - Sleep
KW  - Vigilance
N1  - Accession Number: 11046049; Berger, Ralph J. 1 Meier, Gilbert W. 1; Affiliation:  1: Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico.; Source Info: Oct1965, Vol. 2 Issue 2, p141; Subject Term: NEURAL analyzers; Subject Term: SLEEP; Subject Term: VIGILANCE (Psychology); Subject Term: CENTRAL nervous system; Subject Term: SLEEP-wake cycle; Subject Term: DREAMS; Author-Supplied Keyword: Analyzer; Author-Supplied Keyword: Dreaming.; Author-Supplied Keyword: Sleep; Author-Supplied Keyword: Vigilance; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Bower, Eli M.
T1  - The Return of Rumpelstiltskin: Reaction to Mesinger's Article.
JO  - Exceptional Children
JF  - Exceptional Children
Y1  - 1965/12//
VL  - 32
IS  - 4
M3  - Letter
SP  - 238
EP  - 239
SN  - 00144029
AB  - A letter to the editor is presented in response to the article "Emotionally Disturbed and Brain Damaged Children: Should We Mix Them?" published within the issue.
KW  - LETTERS to the editor
KW  - EXCEPTIONAL children
N1  - Accession Number: 19692833; Bower, Eli M. 1; Affiliation:  1: Consultant, Mental Health in Education, Research Utilization Branch, National Institute of Mental Health, Bethesda, Maryland; Source Info: Dec1965, Vol. 32 Issue 4, p238; Subject Term: LETTERS to the editor; Subject Term: EXCEPTIONAL children; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dittmann, Allen T.
T1  - PSYCHOTHERAPEUTIC PROCESSES.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1966/02//
VL  - 17
IS  - 1
M3  - Article
SP  - 51
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11298999; Dittmann, Allen T. 1; Affiliation:  1: National Institute of Mental Health in Bethesda, Maryland; Source Info: 1966, Vol. 17 Issue 1, p51; Number of Pages: 28p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zolik, Edwin S.
AU  - Marcres, Joseph B.
T1  - AN APPARENT "ZONE OF INVISIBILITY" IN COMMUNITY MENTAL HEALTH PROGRAMS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1966/04//
VL  - 22
IS  - 2
M3  - Article
SP  - 239
EP  - 245
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article presents a study in which the percentage distribution by age group of cases reported as having a functional non-psychotic disorder for two patient samples is presented. To determine whether the low prevalence evidenced in the 18-24 year group was affected by the absence from Northern Virginia of individuals obtaining post high school education an analysis was done of the institutions attended by 1607 high school graduates. Results suggest the existence of a "zone of invisibility" in community mental health practice with regard to individuals in the 18-24 age range. Socio-cultural factors appear to be the major variables contributing to this apparent invisibility. Methods for increasing visibility or contact with these persons and other implications are discussed.
KW  - MENTAL health
KW  - AGE groups
KW  - PSYCHOSES
KW  - PATIENTS
KW  - SCHOOLS
KW  - SOCIOCULTURAL factors
N1  - Accession Number: 15844451; Zolik, Edwin S. 1 Marcres, Joseph B. 2; Affiliation:  1: De Paul University Chicago, Illinois  2: National Institute of Mental Health Bethesda, Maryland.; Source Info: Apr1966, Vol. 22 Issue 2, p239; Subject Term: MENTAL health; Subject Term: AGE groups; Subject Term: PSYCHOSES; Subject Term: PATIENTS; Subject Term: SCHOOLS; Subject Term: SOCIOCULTURAL factors; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 611110 Elementary and Secondary Schools; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jones, B. E.
AU  - Ayres, J. J. B.
T1  - SIGNIFICANCE AND RELIABILITY OF SHOCK-IN-DUCED CHANGES IN BASAL SKIN CONDUCTANCE.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1966/04//
VL  - 2
IS  - 4
M3  - Article
SP  - 322
EP  - 326
SN  - 00485772
AB  - Once weekly for 5 weeks, 15 adult male postaddicts were given 12 to 15 shocks of 5.0 to 8.0 ma. Basal skin conductance (BSC) was recorded during the 25-rain weekly sessions. Increases in BSC during each session and the week-to-week reliabilities of the increases were determined. After the first week, subsequent increases showed reliability coefficients which ranged from 0.69 to 0.95 (P < 0.01). The reliabilities of the increases in BSC produced by shock were considered favorable for the use of change in BSC as a dependent variable in designs requiring repeated measurements on the same Ss at weekly intervals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GALVANIC skin response
KW  - REFLEXES
KW  - SKIN -- Physiology
KW  - RELIABILITY (Personality trait)
KW  - Basal Skin Conductance. (B. E. Jones)
KW  - Methodology
N1  - Accession Number: 11047181; Jones, B. E. 1 Ayres, J. J. B. 1; Affiliation:  1: National Institute of Mental Health Addiction Research Center, Lexington, Kentucky.; Source Info: Apr1966, Vol. 2 Issue 4, p322; Subject Term: GALVANIC skin response; Subject Term: REFLEXES; Subject Term: SKIN -- Physiology; Subject Term: RELIABILITY (Personality trait); Author-Supplied Keyword: Basal Skin Conductance. (B. E. Jones); Author-Supplied Keyword: Methodology; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Berger, Ralph J.
AU  - Meier, Gilbert W.
T1  - THE EFFECTS OF SELECTIVE DEPRIVATION OF STATES OF SLEEP IN THE DEVELOPING MONKEY.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1966/04//
VL  - 2
IS  - 4
M3  - Article
SP  - 354
EP  - 371
SN  - 00485772
AB  - Four groups, two comprising three neonatal rhesus monkeys and two comprising two juvenile rhesus monkeys, were selectively deprived of either low-voltage, fastwave sleep (LVF) or of high.voltage, slow-wave sleep (HVS), respectively. Both infant and juvenile Ss displayed an over-all increase in threshold to the tone-shock combination during the deprivation of either phase of sleep. However, the thresholds of the infant Ss were greater, throughout deprivation, than the thresholds of the juvenile Ss. The juvenile Ss exposed to LVF deprivation were unique in exhibiting a sharp increase in frequency of forced awakenings from LVF, to values significantly greater than for the other groups, and in displaying compensatory recovery effects, manifested by increases in proportion of total sleep time spent in LVF, following termination of deprivation. Behavioral disturbances accompanying deprivation were not evident in any of the experimental groups. The study revealed a number of methodological problems related to the definition and to the selective deprivation of a particular state of sleep. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SLEEP deprivation
KW  - AROUSAL (Physiology)
KW  - PSYCHOPHYSIOLOGY
KW  - ONTOGENY
KW  - Arousal
KW  - Dream deprivation
KW  - Ontogeny. (R. J. Berger)
KW  - Sleep deprivation
N1  - Accession Number: 11047250; Berger, Ralph J. 1 Meier, Gilbert W. 1; Affiliation:  1: Laboratory of Perinatal Physiology, National  Institute of Neurological Diseases and Blindness, National  Institutes of Health, San Juan, Puerto Rico.; Source Info: Apr1966, Vol. 2 Issue 4, p354; Subject Term: SLEEP deprivation; Subject Term: AROUSAL (Physiology); Subject Term: PSYCHOPHYSIOLOGY; Subject Term: ONTOGENY; Author-Supplied Keyword: Arousal; Author-Supplied Keyword: Dream deprivation; Author-Supplied Keyword: Ontogeny. (R. J. Berger); Author-Supplied Keyword: Sleep deprivation; Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Myers, J.
AU  - Frei, J. V.
AU  - Cohen, J. J.
AU  - Rose, B.
AU  - Richter, M.
T1  - Basement Membrane Specific Antisera Produced to Solubilized Tissue Fractions.
JO  - Immunology
JF  - Immunology
Y1  - 1966/08//
VL  - 11
IS  - 2
M3  - Article
SP  - 155
EP  - 162
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Attempts were made to produce antisera to solubilized tissue fractions rich in basement membranes and reticulin. Murine tissue fractions solubilized with sodium hydroxide elicited precipitating antibodies upon injection into rabbits. Although no nephrotoxic effect was observed upon injecting the rabbit antisera into mice, the antisera were fixed to the glomerular basement membrane, and not elsewhere, within 5 minutes of injection and remained fixed for at least 3 weeks. Specificity studies suggested that in addition to unique antigens, reticulin and epithelial basement membranes share a common antigen which is responsible for the similar in vitro immunofluorescence produced by antisera to tissue fractions rich in one or the other of these components. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL lamina
KW  - IMMUNE serums
KW  - TISSUES
KW  - SODIUM hydroxide
KW  - IMMUNOGLOBULINS
KW  - RABBITS as laboratory animals
KW  - ANTIGENS
N1  - Accession Number: 13284172; Myers, J. 1 Frei, J. V. 2 Cohen, J. J. 3,4 Rose, B. 3,4 Richter, M. 5; Affiliation:  1: United States Public Health Service Special Research Fellow.  2: Research Associate, National Cancer Institute of Canada.  3: Division of Immunochemistry and Allergy, Royal Victoria, Hospital, Canada.  4: Department of Pathology, McGill University, Montreal, Quebec, Canada.  5: Medical Research Associate, Medical Research Council, Canada.; Source Info: Aug66, Vol. 11 Issue 2, p155; Subject Term: BASAL lamina; Subject Term: IMMUNE serums; Subject Term: TISSUES; Subject Term: SODIUM hydroxide; Subject Term: IMMUNOGLOBULINS; Subject Term: RABBITS as laboratory animals; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325181 Alkali and chlorine manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mergenhagen, S. E.
AU  - Notkins, A. L.
AU  - Evans, R. T.
T1  - Passive Haemagglutination for Estimation of Early and Late Anti-Human γ-Globulin Antibodies.
JO  - Immunology
JF  - Immunology
Y1  - 1966/09//
VL  - 11
IS  - 3
M3  - Article
SP  - 223
EP  - 228
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The influence of various concentrations of human y-globulin (HGG) employed to sensitize tanned sheep erythrocytes on haemagglutination titres with various early and late mouse and rabbit antisera to HGG has been studied. The concentration of HGG employed to sensitize tanned erythrocytes which gives the highest haemagglutination titres with early, mercaptoethanol- sensitive antibodies was not optimal for obtaining highest haemagglutination titres with late, mercaptoethanol-insensitive antibodies. Similar results were obtained with heavy and light sucrose gradient ultracentrifugation fractions of a late and early rabbit antiserum. These findings may account for past discrepancies and should be considered when employing the haemagglutination test to detect early and late antibodies.
KW  - GAMMA globulins
KW  - IMMUNOGLOBULINS
KW  - AGGLUTINATION of blood
KW  - IMMUNE serums
KW  - ERYTHROCYTES
KW  - ANTIGEN-antibody reactions
N1  - Accession Number: 14578238; Mergenhagen, S. E. Notkins, A. L. 1 Evans, R. T. 1; Affiliation:  1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, .National Institute of Dental Research, Bethesda, Maryland 20014; Source Info: Sep66, Vol. 11 Issue 3, p223; Subject Term: GAMMA globulins; Subject Term: IMMUNOGLOBULINS; Subject Term: AGGLUTINATION of blood; Subject Term: IMMUNE serums; Subject Term: ERYTHROCYTES; Subject Term: ANTIGEN-antibody reactions; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gorsuch, Richard L.
AU  - Spielberger, Charles D.
T1  - Anxiety, threat, and awareness in verbal conditioning.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1966/09//
VL  - 34
IS  - 3
M3  - Article
SP  - 336
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8933677; Gorsuch, Richard L. 1 Spielberger, Charles D. 2; Affiliation:  1: Vanderbilt University.  2: National Institute for Mental Health, Bethesda, Maryland.; Source Info: Sep66, Vol. 34 Issue 3, p336; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1467-6494.ep8933677
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raskin, Allen
AU  - Schulterbrandt, Joy G.
AU  - Reatig, Natalie
T1  - RATER AND PATIENT CHARACTERISTICS ASSOCIATED WITH RATER DIFFERENCES IN PSYCHIATRIC SCALE RATINGS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1966/10//
VL  - 22
IS  - 4
M3  - Article
SP  - 417
EP  - 423
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article presents information on psychiatric scales rating. The Inpatient Multidimensional Psychiatric Scale (IMPS) is designed for use by psychiatrists and psychologists following a 30 to 60 minute interview with the patient. Although the reported reliabilities of the 10 IMPS factor scores derived from this scale are high the background of the rater plays some part in rating the presence and magnitude of specified forms of psychopathology.
KW  - MENTAL health personnel
KW  - NEUROLOGISTS
KW  - PSYCHIATRISTS
KW  - BEHAVIOR
KW  - PATHOLOGICAL psychology
KW  - PUBLIC health
N1  - Accession Number: 15980569; Raskin, Allen 1 Schulterbrandt, Joy G. 1 Reatig, Natalie 1; Affiliation:  1: National Institute of Mental Health, Bethesda, Maryland; Source Info: Oct1966, Vol. 22 Issue 4, p417; Subject Term: MENTAL health personnel; Subject Term: NEUROLOGISTS; Subject Term: PSYCHIATRISTS; Subject Term: BEHAVIOR; Subject Term: PATHOLOGICAL psychology; Subject Term: PUBLIC health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Oppenheim, J. J.
AU  - Wolstencroft, R. A.
AU  - Gell, P. G. H.
T1  - Delayed Hypersensitivity in the Guinea-Pig to a Protein-Hapten Conjugate and its Relationship to <em>in vitro</em> Transformation of Lymph Node, Spleen, Thymus and Peripheral Blood Lymphocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1967/01//
VL  - 12
IS  - 1
M3  - Article
SP  - 89
EP  - 102
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Guinea-pig delayed hypersensitivity to purified protein derivative (PPD) and guinea-pig albumin-orthanilic acid (AO) was produced in the absence of detectable antibody formation to the conjugate. Ten days after sensitization the guinea-pig peripheral leucocytes, lymph nodes, spleen and thymus cell suspensions were cultured from 1 to 5 days with various concentrations of immunizing antigens, unconjugated hapten, a hapten—ovalbumin conjugate or phytohaemagglutinin (PHA). All the cultures of ‘draining’ lymph node cells, and about 40 per cent of the spleen and peripheral leucocyte cultures manifested increased lymphocyte transformation on radioautographs, and by total tritiated thymidine incorporation when stimulated by PPD or AO. In addition all the cultures responded well to PHA. However, lymphocytes from the mediastinal and cervical lymph nodes from the immunized, and most of the lymphoid organ cultures from unimmunized guinea-pigs were not stimulated by antigens but responded only to PHA. Cultured guinea-pig thymocytes did not respond to any stimulus. The in vitro lymphocyte proliferation was carrier specific. It did not occur in response to unconjugated hapten. However, the response to AO was partially inhibited in the presence of the hapten. The in vitro kinetics and morphological changes in the cultures also were investigated, and the immunological significance and specificity of lymphocyte transformation are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALBUMINS
KW  - PROTEINS
KW  - LEUCOCYTES
KW  - KILLER cells
KW  - BLOOD cells
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGY
N1  - Accession Number: 13320964; Oppenheim, J. J. 1 Wolstencroft, R. A. 2 Gell, P. G. H. 2; Affiliation:  1: NIDR, National Institutes of Health, Bethesda, U.S.A.  2: Department of Experimental Pathology, University of Birmingham; Source Info: Jan67, Vol. 12 Issue 1, p89; Subject Term: ALBUMINS; Subject Term: PROTEINS; Subject Term: LEUCOCYTES; Subject Term: KILLER cells; Subject Term: BLOOD cells; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGY; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - The Theory of Road Traffic Flow (Book).
JO  - Transportation Science
JF  - Transportation Science
Y1  - 1967/02//
VL  - 1
IS  - 1
M3  - Book Review
SP  - 47
PB  - INFORMS: Institute for Operations Research
SN  - 00411655
AB  - Reviews the book "The Theory of Road Traffic Flow," by Winifred D. Ashton.
KW  - TRAFFIC flow
KW  - NONFICTION
KW  - ASHTON, Winifred
KW  - ASHTON, Winifred D.
KW  - THEORY of Road Traffic Flow, The (Book)
N1  - Accession Number: 4471158; Weiss, George H. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland.; Source Info: Feb67, Vol. 1 Issue 1, p47; Subject Term: TRAFFIC flow; Subject Term: NONFICTION; Reviews & Products: THEORY of Road Traffic Flow, The (Book); People: ASHTON, Winifred; People: ASHTON, Winifred D.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scott, Phyllis M.
AU  - Burton, Roger V.
AU  - Yarrow, Marian Radke
T1  - SOCIAL REINFORCEMENT UNDER NATURAL CONDITIONS.
JO  - Child Development
JF  - Child Development
Y1  - 1967/03//
VL  - 38
IS  - 1
M3  - Article
SP  - 53
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 10429504; Scott, Phyllis M. 1 Burton, Roger V. 1 Yarrow, Marian Radke 1; Affiliation:  1: National Institute of Mental Health; Source Info: Mar1967, Vol. 38 Issue 1, p53; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hall, William T.
AU  - Claus, George
T1  - ULTRASTRUCTURAL STUDIES ON THE CYANELLES OF CLAUCOCYSTIS NOSTOCHINEARUM ITZIGSOHN.
JO  - Journal of Phycology
JF  - Journal of Phycology
Y1  - 1967/03//
VL  - 3
IS  - 1
M3  - Article
SP  - 37
EP  - 51
SN  - 00223646
AB  - Ultrastructural studies conducted on the intracellular symbiont of Glaucocystis nostochinearum Itz., a unicellular alga with a debated taxonomic position have shown that the endosymbiont, although somewhat aberrant, is a blue-green alga. Due possibly to its intracellular habitat, it lacks the characteristic cyanophycean double-layered cell wall and the cells appear to be completely naked, bound only by a single plasma membrane. The protoplasm of the cell is differentiated into the lamellated chromatoplasm, which contains the photosynthetic pigments and poly-phosphate granules, and a nonlamellar centroplasm, in winch the nucleic material is dispersed. The usual cyanophycean organelles, as well as the different vacuoles and granules, with the exception of the formed bodies, are missing. Approximately 10% of the cells shows a peculiar homogeneous area at one tip, nature of which is unknown. Binary fission the organism is mentioned. Since this cyanelle not yet been classified, we name it Skujapelta nuda nov. gen., nov. sp.; and because of its structural peculiarities we find it necessary to create a new family for it, Skujapeltaceae in the order Chroococcales. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - HABITAT (Ecology)
KW  - CELL membranes
KW  - BIOLOGICAL pigments
KW  - PAINT materials
KW  - ART materials
N1  - Accession Number: 11578700; Hall, William T. 1 Claus, George 2; Affiliation:  1: National Cancer Institute, Bethesda, Maryland 20014.  2: Graduate Department of Marine Science, Long Island University, Brookville; Source Info: Mar1967, Vol. 3 Issue 1, p37; Subject Term: CELLS; Subject Term: HABITAT (Ecology); Subject Term: CELL membranes; Subject Term: BIOLOGICAL pigments; Subject Term: PAINT materials; Subject Term: ART materials; NAICS/Industry Codes: 339940 Office Supplies (except Paper) Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 424950 Paint, Varnish, and Supplies Merchant Wholesalers; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ben-Efraim, S.
AU  - Fuchs, Sara
AU  - Sela, M.
T1  - Differences in Immune Response to Synthetic Antigens in Two Inbred Strains of Guinea-Pigs.
JO  - Immunology
JF  - Immunology
Y1  - 1967/05//
VL  - 12
IS  - 5
M3  - Article
SP  - 573
EP  - 581
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The study of the immunogenicity of some linear and multichain synthetic polypetides in guinea-pigs, of inbred strains 2 and 13 led to their division into three categories: (a) immunogenic in both inbred strains: linear copolymer of tyrosine, glutamic acid and alanine; (b) irnmunogenic in strain 13 and negative in strain 2: linear copolymer of tyrosine and glutamic acid; and (c) immunogenic in strain 2 and negative in strain 13 : linear and branched copolymers containing lysine. No immune response was detected in strain 2 guinea-pigs to the copolymer of tyrosine, glutamic acid and lysine, composed only of the D-optical isomers. The immune response, or lack of response, in F1 hybrids of the inbred strains was identical with that of inbred strain 2 suggesting that the genetic determinants of this strain are dominant. No cross-reactions were observed at the delayed stage in inbred strain 2 between linear and multichain copolymers of similar composition.
KW  - PEPTIDES
KW  - TYROSINE
KW  - GLUTAMIC acid
KW  - ALANINE
KW  - LYSINE
KW  - COPOLYMERS
KW  - OPTICAL isomers
KW  - GUINEA pigs as laboratory animals
N1  - Accession Number: 13331987; Ben-Efraim, S. 1,2 Fuchs, Sara 1,2 Sela, M. 1,2; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland  2: Section of Chemical Immunology, The Weizmann Institute of Science, Rehovoth, Israel; Source Info: May67, Vol. 12 Issue 5, p573; Subject Term: PEPTIDES; Subject Term: TYROSINE; Subject Term: GLUTAMIC acid; Subject Term: ALANINE; Subject Term: LYSINE; Subject Term: COPOLYMERS; Subject Term: OPTICAL isomers; Subject Term: GUINEA pigs as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Asherson, G. L.
AU  - Stone, S. H.
T1  - Desensitization <em>in vitro</em>-The Specific Inhibition, by Antigen, of the Passive Transfer of Delayed Hypersensitivity by Peritoneal Exudate Cells.
JO  - Immunology
JF  - Immunology
Y1  - 1967/11//
VL  - 13
IS  - 5
M3  - Article
SP  - 469
EP  - 475
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A preliminary experiment showed that the injection of bovine γ-globulin into guinea-pigs with delayed hypersensitivity to bovine γ-globulin reduced the 24-hour skin reactions to bovine γ-globulin and (to a lesser extent) PPD. The peritoneal exudate cells from the desensitized donors had a reduced ability to transfer delayed hypersensitivity to bovine γ-globulin but a normal ability to transfer delayed hypersensitivity to PPD. Likewise, it was possible to diminish the passive transfer of delayed hypersensitivity to bovine γ-globulin by peritoneal exudate cells, by exposure of the ceils to bovine γ-globulin in vitro. The recipients were tested immediately after cell transfer. This in vitro desensitization was specific, in that the transfer of delayed hypersensitivity to PPD was unaffected. Exposure of cells in vitro to hypotonic conditions and antibody to guinea-pig γ-globulin did not prevent the passive transfer of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALLERGY desensitization
KW  - ALLERGY
KW  - GLOBULINS
KW  - ANTIGENS
KW  - ANIMAL models in research
KW  - IMMUNOLOGY
N1  - Accession Number: 13342845; Asherson, G. L. 1 Stone, S. H. 2; Affiliation:  1: Department of Bacteriology, London Hospital Medical College, London, England  2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA; Source Info: Nov67, Vol. 13 Issue 5, p469; Subject Term: ALLERGY desensitization; Subject Term: ALLERGY; Subject Term: GLOBULINS; Subject Term: ANTIGENS; Subject Term: ANIMAL models in research; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Drews, J.
AU  - Brawerman, G.
AU  - Morris, H. P.
T1  - Nucleotide Sequence Homologies in Nuclear and Cytoplasmic Ribonucleic Acid from Rat Liver and Hepatomas.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1968/01//
VL  - 3
IS  - 3
M3  - Article
SP  - 284
EP  - 292
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The RNA populations of rat liver and three rat hepatomas were compared by DNA-RNA hybridization studies in the presence and absence of competing RNA. The hepatoma nuclei were found to lack hybridizable RNA species present in normal liver nuclei, while the latter appeared to contain all the hepatoma RNA species. In normal liver, the cytoplasmic RNA could compete with nuclear RNA only to the extent of 20–30%. This indicates that a large number of nuclear RNA species are not transferred to the cytoplasm. In the case of the hepatomas nearly all the nuclear RNA species were detected in the cytoplasmic RNA preparations. A more extensive homology between nuclear and cytoplasmic RNA was also observed in regenerating liver. It is suggested that a selective mechanism governs the transfer of RNA species from the nucleus to the cytoplasm and that this mechanism is altered in the hepatomas. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOMOLOGY (Biology)
KW  - NUCLEOTIDE sequence
KW  - RNA
KW  - LIVER tumors
KW  - HEPATOMA
KW  - RATS as laboratory animals
N1  - Accession Number: 12768108; Drews, J. 1,2 Brawerman, G. 2,3 Morris, H. P. 2,4; Affiliation:  1: Medizinische Universitätsklinik, Bergheimer, Germany  2: Department of Medicine and Biochemistry, Yale University School of Medicine and National Cancer Institute, Nutrition and Biochemistry Section  3: Institut de Biologie physico-chimique, Curie, Paris-5, France  4: Nutrition and Carcinogenesis Section, National Cancer Institute, Bethesda, USA; Source Info: 1968, Vol. 3 Issue 3, p284; Subject Term: HOMOLOGY (Biology); Subject Term: NUCLEOTIDE sequence; Subject Term: RNA; Subject Term: LIVER tumors; Subject Term: HEPATOMA; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Haertzen, C. A.
AU  - Hooks, N. T.
AU  - Monroe, J. J.
AU  - Fuller, Gerald B.
AU  - Sharp, Heber
T1  - NONSIGNIFICANCE OF MEMBERSHIP IN ALCOHOLICS ANONYMOUS IN HOSPITALIZED ALCOHOLICS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1968/01//
VL  - 24
IS  - 1
M3  - Article
SP  - 99
EP  - 103
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses nonsignificance of membership in alcoholics anonymous in hospitalized alcoholics. Members and nonmembers of AA in a hospital setting were compared on the Addiction Research Center Inventory (ARCI) and Inventory of Habits and Attitudes (lHA). Both tests measure personality and adjustment characteristics, but the former test is a sensitive measure of subjective experience associated with drugs and alcohol withdrawal, whereas the IHA test gives an indication of the history of alcohol use, functional utility of alcohol, environmental press for using alcohol, and acceptability for therapy. In studies of these tests involving over 700 Ss, AA membership was not a significant determinant of individual differences in response.
KW  - ALCOHOLICS
KW  - ATTITUDE (Psychology)
KW  - RESEARCH institutes
KW  - DRINKING of alcoholic beverages
KW  - DIFFERENTIAL psychology
KW  - PSYCHOLOGICAL tests
N1  - Accession Number: 15866117; Haertzen, C. A. 1 Hooks, N. T. 1 Monroe, J. J. 1 Fuller, Gerald B. 2 Sharp, Heber 3; Affiliation:  1: National Institute of Mental Health, Addiction Research Center, Lexington, Ky.  2: Central Michigan University.  3: Willmar (Minn.) State Hospital.; Source Info: Jan1968, Vol. 24 Issue 1, p99; Subject Term: ALCOHOLICS; Subject Term: ATTITUDE (Psychology); Subject Term: RESEARCH institutes; Subject Term: DRINKING of alcoholic beverages; Subject Term: DIFFERENTIAL psychology; Subject Term: PSYCHOLOGICAL tests; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zolik, Edwin S.
AU  - Marches, Joseph R.
T1  - MENTAL HEALTH MORBIDITY IN A SUBURBAN COMMUNITY.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1968/01//
VL  - 24
IS  - 1
M3  - Article
SP  - 103
EP  - 108
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses mental health morbidity in a suburban community. It reports the prevalence of mental disorders in the population served by the agencies responsible for the public mental health sector of services in a rapidly growing suburban area. In the course of one week 1,516 individuals with mental or emotional disorders were reported. Analyses of the age by sex by type of disorder revealed differential morbidity rates among children and adults. Among children, males exceeded females but among adults the ratio was reversed. Married females were reported twice as frequently as married males. Psychoneurosis and personality disturbances were the two predominant disorders among adults whereas mental deficiency and personality disorders were predominant among children.
KW  - MENTAL health
KW  - PERSONALITY in children
KW  - HUMAN sexuality
KW  - FEMALES
KW  - HAPPINESS
KW  - PATHOLOGICAL psychology
N1  - Accession Number: 15866118; Zolik, Edwin S. 1 Marches, Joseph R. 2; Affiliation:  1: De Paul University.  2: National Institute for Mental Health Chicago, Illinois Bethesda, Maryland.; Source Info: Jan1968, Vol. 24 Issue 1, p103; Subject Term: MENTAL health; Subject Term: PERSONALITY in children; Subject Term: HUMAN sexuality; Subject Term: FEMALES; Subject Term: HAPPINESS; Subject Term: PATHOLOGICAL psychology; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lansdell, H.
AU  - Polcari, A. R.
T1  - THE MEANING OF THE TAULBEE-SISSON CONFIGURATIONAL SCORE ON THE MMPI WITH NEUROSURGICAL PATIENTS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1968/04//
VL  - 24
IS  - 2
M3  - Article
SP  - 216
EP  - 219
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article focuses on the meaning of the Taulbee-sission configurational score in the MMPI with neurological patients. In a previous investigation of the effect of temporal lobe removals on MMPI scores, a problem was raised with respect to the meaning of the Taulbe&Sisson (TS) configurational score with epileptic patients who had undergone neurosurgical therapy. The original purpose of the TS score is to help psychodiagnosticians decide on the basis of a pattern of scores whether a patient in a psychiatric hospital might be labeled neurotic or psychotic, but the labels do not seem adequate to describe patients with neurological impairments.
KW  - TALLIES
KW  - MINNESOTA Multiphasic Personality Inventory
KW  - NEUROSURGERY
KW  - PATIENTS
KW  - EPILEPSY
KW  - PSYCHODIAGNOSTICS
N1  - Accession Number: 15844756; Lansdell, H. 1 Polcari, A. R. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland.; Source Info: Apr1968, Vol. 24 Issue 2, p216; Subject Term: TALLIES; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: NEUROSURGERY; Subject Term: PATIENTS; Subject Term: EPILEPSY; Subject Term: PSYCHODIAGNOSTICS; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Waldrop, Mary F.
AU  - Pedersen, Frank A.
AU  - Bell, Richard Q.
T1  - MINOR PHYSICAL ANOMALIES AND BEHAVIOR IN PRESCHOOL CHILDREN.
JO  - Child Development
JF  - Child Development
Y1  - 1968/06//
VL  - 39
IS  - 2
M3  - Article
SP  - 391
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 10398133; Waldrop, Mary F. 1 Pedersen, Frank A. 1 Bell, Richard Q. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1968, Vol. 39 Issue 2, p391; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moss, Howard A.
AU  - Robson, Kenneth S.
T1  - MATERNAL INFLUENCES IN EARLY SOCIAL VISUAL BEHAVIOR.
JO  - Child Development
JF  - Child Development
Y1  - 1968/06//
VL  - 39
IS  - 2
M3  - Article
SP  - 401
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 10398096; Moss, Howard A. 1 Robson, Kenneth S. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1968, Vol. 39 Issue 2, p401; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Draper, L.R.
AU  - Hirata, A.A.
T1  - Antibody Responses in Rabbits to Soluble and Particulate Forms of Bovine Serum Albumin.
JO  - Immunology
JF  - Immunology
Y1  - 1968/07//
VL  - 15
IS  - 1
M3  - Article
SP  - 23
EP  - 30
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Antibody responses to an insoluble derivative of bovine serum albumin (IBSA) and to its corresponding soluble form (SBSA) were compared in rabbits. The two antigens could not be distinguished serologically. Less IBSA than SBSA was required to induce a detectable primary response. At higher doses, 10-20 mg/kg, IBSA evoked more prompt primary and secondary responses than SBSA but peak litres were sometimes higher in the SBSA group. After secondary injections, serum antibody litre persisted for at least 18 months in most rabbits. Early in the primary response to either form of antigen a substantial proportion of the serum antibody was of the 19S type. The shift to 7S production occurred abruptly and early after IBSA injection but it was gradual after SBSA injection, which suggested a relatively prolonged period of induction in the latter case. 75 antibody predominated during the secondary response to both antigens although the proportion of 1 9S antibody increased somewhat 4 weeks after the reinjection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - GLOBULINS
KW  - ANTIGENS
KW  - PLASMA cells
KW  - IMMUNITY
KW  - IMMUNOLOGY
N1  - Accession Number: 13346171; Draper, L.R. 1 Hirata, A.A. 1; Affiliation:  1: Laboratory of Physiology, National Cancer Institute, Bethesda, Mayland; and 20014 Department of Molecular Biology, Abbott Laboratories, North Chicago, Illinois 60064; Source Info: Jul68, Vol. 15 Issue 1, p23; Subject Term: IMMUNOGLOBULINS; Subject Term: GLOBULINS; Subject Term: ANTIGENS; Subject Term: PLASMA cells; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bowen, W. J.
AU  - Evans Jr., T. C.
T1  - The Binding of ATP to Myosins B and A.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1968/09//
VL  - 5
IS  - 4
M3  - Article
SP  - 507
EP  - 512
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Values for binding of ATP and ADP to myosin B and ATP to myosin A were determined from mixtures of these nucleotides and proteins by use of rapid filtration to separate bound and unbound nucleotides and by use of an ATP-regenerating system (ereatine phosphate­creatine phosphokinase). Calculation of the binding curves of ATP to 105 g of myosin B by the mass law binding expression using two sets of binding sites, n1 and n2, and with binding constants, k1=40 × 103 and k2=1.5 × 103 1/mole, respectively, yielded a curve of good fit to the experimentally determined points when n1=0.4 and n2=1.2 moles per l05 g. Similar calculation of data from binding of ATP to myosin A fielded a curve of best fit when n1=0.5 and n2=3.0 per 105 g with k1=5,500 and k2=550 1/mole. At 1 mM ATP, myosin A bound 50% more than myosin B. ADP at 1 mM appeared to saturate myosin B about 97%. The amounts of ADP bound to myosin B fitted a curve with one value of n which equaled 0.36. Multiplication of 105 g by the factors required to convert the above n values to integers fields combining weights of 250,000 and 200,000 for myosin B and myosin A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADENOSINE triphosphate
KW  - MYOSIN
KW  - NUCLEOTIDES
KW  - PROTEINS
KW  - BIOCHEMISTRY
KW  - CREATINE
N1  - Accession Number: 12791312; Bowen, W. J. 1,2 Evans Jr., T. C. 1,3; Affiliation:  1: National Institute of Arthritis and Metabolic Diseases National Institutes of Health, Public Health Service U.S. Department of Health, Education and Welfare Bethesda, Maryland  2: Bldg. 4, Room B1-06 Lab. Biophysical Chemistry National Institutes of Health, National Institute of Artritis and Metabolic Diseases, Bethesda, Maryland 20014, U.S.A.  3: Mayo Clinic, Rochester, Minnesota, 55901, U.S.A.; Source Info: 1968, Vol. 5 Issue 4, p507; Subject Term: ADENOSINE triphosphate; Subject Term: MYOSIN; Subject Term: NUCLEOTIDES; Subject Term: PROTEINS; Subject Term: BIOCHEMISTRY; Subject Term: CREATINE; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Colten, H. R.
AU  - Silverstein, A. M.
AU  - Bonos, T.
AU  - Rapp, H. J.
T1  - Ontogeny of the First Component of Sheep Complement.
JO  - Immunology
JF  - Immunology
Y1  - 1968/09//
VL  - 15
IS  - 3
M3  - Article
SP  - 459
EP  - 461
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Discusses a study on the appearance of hemolytic complement activity in the sera of embryonic sheep. Whole complement activity in sera of fetal lambs discovered after the 123rd day of gestation; Description of the hemolytic C activity which depends on the presence of all the C components in the serum; Insensitivity of titres of hemolytic C to large variations in the concentration of some of the components.
KW  - SHEEP
KW  - LIVESTOCK
KW  - HEMOLYSIS & hemolysins
KW  - IMMUNITY
KW  - BLOOD
KW  - ANTIGEN-antibody reactions
N1  - Accession Number: 13347662; Colten, H. R. 1 Silverstein, A. M. 1 Bonos, T. 1 Rapp, H. J. 1; Affiliation:  1: Biology Branch, National Cancer Institute, Maryland, the Wilmer Institute, Johns Hopkins Hospital, Baltimore, Maryland; Source Info: Sep68, Vol. 15 Issue 3, p459; Subject Term: SHEEP; Subject Term: LIVESTOCK; Subject Term: HEMOLYSIS & hemolysins; Subject Term: IMMUNITY; Subject Term: BLOOD; Subject Term: ANTIGEN-antibody reactions; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112410 Sheep Farming; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Parloff, Morris B.
AU  - Datta, Lois-Ellin
AU  - Kleman, Marianne
AU  - Handlon, Joseph H.
T1  - Personality characteristics which differentiate creative male adolescents and adults.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1968/12//
VL  - 36
IS  - 4
M3  - Article
SP  - 528
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 8933214; Parloff, Morris B. 1 Datta, Lois-Ellin 1 Kleman, Marianne 2 Handlon, Joseph H. 3; Affiliation:  1: National Institute of Mental Health.  2: California Department of Public Health, Berkeley.  3: Case Western Reserve University.; Source Info: Dec68, Vol. 36 Issue 4, p528; Number of Pages: 25p; Document Type: Article
L3  - 10.1111/1467-6494.ep8933214
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Oppenheim, J. J.
AU  - Rogentine, G. N.
AU  - Terry, W. D.
T1  - The Transformation of Human Lymphocytes by Monkey Antisera to Human Immunoglobulins.
JO  - Immunology
JF  - Immunology
Y1  - 1969/01//
VL  - 16
IS  - 1
M3  - Article
SP  - 123
EP  - 138
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Cultures of human peripheral leucocytes were stimulated to incorporate tritiated thymidine when incubated with monkey antisera to human immunoglobulins. Twenty-five of forty-four monkey antisera were active and stimulated 90 per cent of leucocyte (WBC) cultures to incorporate a small but significantly greater amount of tritiated thymidine (TdR3H) than that incorporated by controls. This stimulation of TdR3H uptake correlated with an increase from 2 to 8 per cent lymphoblasts in the cultures. Leucocytes washed free of serum immunoglobulins responded to a greater degree to the anti-immunoglobulin sera than when they were cultured in the presence of human serum. Prior absorption of antisera with either whole serum or homologous immunoglobulin blocked anti-serum stimulation completely. The anti-IgG and anti-IgM antisera were consistently more effective than anti-IgA, anti-K and anti-A chain antisera. Sequential stimulation by antisera against two different immunoglobulins was not significantly different from those stimulated by only one of the two, Lymphocytes from three asymptomatic subjects with low or absent serum IgA levels transformed as well with anti-IgA as did lymphocytes from subjects with normal serum IgA levels. Antisera were cytotoxic to the lymphocytes only in the presence of complement. Presumably the transformation of human lymphocytes was due to a reaction of anti-immunoglobulin antisera with specific immunoglobulin antigenic determinants present on or in the circulating lymphocytes.
KW  - LEUCOCYTES
KW  - IMMUNE serums
KW  - IMMUNOGLOBULINS
KW  - BLOOD cells
KW  - LYMPHOCYTES
KW  - IMMUNOLOGY
N1  - Accession Number: 13350488; Oppenheim, J. J. 1 Rogentine, G. N. 1 Terry, W. D. 1; Affiliation:  1: National Institutes of Health, The National Institute of Dental Research, and the National Cancer Institute, Bethesda, Maryland; Source Info: Jan69, Vol. 16 Issue 1, p123; Subject Term: LEUCOCYTES; Subject Term: IMMUNE serums; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD cells; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Frazier, Thomas W.
AU  - Weil-Malherbe, Hans
AU  - Lipscomb, Harry S.
T1  - PSYCHOPHYSIOLOGY OF CONDITIONED EMOTIONAL DISTURBANCES IN HUMANS.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1969/03//
VL  - 5
IS  - 5
M3  - Article
SP  - 478
EP  - 503
SN  - 00485772
AB  - A discriminative avoidance conditioning technique was used to study urinary excretion of selected adrenal hormones in response to a stimulus which had acquired conditioned noxious properties through association with availability of punishment. A four day test procedure was employed: (1) to habituate subjects to the test environment; (2) obtain control data; (3) condition subjects; and (4) test reactions to the conditioned noxious stimulus. Urine samples were taken at two-hour intervals preceding and following each of the four trials, and were analyzed for epinephrine, norepinephrine, total 17-hydroxycorticosteroids, and other urinary constituents. These results were correlated with results obtained from monitoring of heart rate, skin resistance, blood pressure, and three measures of panel monitoring performance. Data analyses revealed significant changes from control levels during the test period for each of the principal measures described above and some specification of life systems interrelationships through correlation and factor analyses. Factors were identified which related to behavioral efficiency, psychological effort, fluid transport regulation, cardiovascular-adrenal, and specific epinephrine and norepinephrine factors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADRENAL cortex
KW  - VIGILANCE (Psychology)
KW  - AUTONOMIC conditioning
KW  - PUNISHMENT (Psychology)
KW  - Adrenal
KW  - Autonomic
KW  - Factor analysis
KW  - Human avoidance conditioning
KW  - Punishment. (T. Frazier)
KW  - Vigilance
N1  - Accession Number: 11237629; Frazier, Thomas W. 1 Weil-Malherbe, Hans 2 Lipscomb, Harry S. 3; Affiliation:  1: Walter Reed Army  Institute of Research.  2: National  Institute of Mental Health,  St. Elizabeth's Hospital.  3: Baylor University College of Medicine.; Source Info: Mar1969, Vol. 5 Issue 5, p478; Subject Term: ADRENAL cortex; Subject Term: VIGILANCE (Psychology); Subject Term: AUTONOMIC conditioning; Subject Term: PUNISHMENT (Psychology); Author-Supplied Keyword: Adrenal; Author-Supplied Keyword: Autonomic; Author-Supplied Keyword: Factor analysis; Author-Supplied Keyword: Human avoidance conditioning; Author-Supplied Keyword: Punishment. (T. Frazier); Author-Supplied Keyword: Vigilance; Number of Pages: 26p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Paul, W. E.
AU  - Thorbecke, G. Jeanette
AU  - Siskind, G. W.
AU  - Benacerraf, B.
T1  - The Effect of Dose in Tolerance Induction on the Subsequent Response to a Cross-Reactive Antigen.
JO  - Immunology
JF  - Immunology
Y1  - 1969/07//
VL  - 17
IS  - 1
M3  - Article
SP  - 85
EP  - 92
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The amount of antibody produced by BSA-tolerant rabbits as a result of immunization with DNP-BSA is dependent upon the amount of BSA used to induce tolerance. Tolerance was induced by initial injection of 100 μg of antigen followed by progressively higher doses. Rabbits rendered tolerant with a maximum BSA dose of 1 mg had a mean serum anti-BSA antibody concentration of 0·39 mg/ml after immunization with DNP-BSA, whereas rabbits rendered tolerant with a maximum BSA dose of 100 mg had a mean serum anti-BSA concentration of 0·02 mg after the same course of immunization. This compares with a mean of 1·08 mg of anti-BSA antibody in normal rabbits immunized with DNP-BSA. There was a similar reduction in the concentration of anti-DNP anti-bodies and of conjugate-specific antibodies in the tolerant groups. The results are discussed in terms of a thermodynamically-controlled induction of tolerance in individual precursor cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - IMMUNIZATION
KW  - RABBITS as laboratory animals
KW  - ADMINISTRATION of drugs
KW  - CELLS
KW  - IMMUNOLOGY
N1  - Accession Number: 13354172; Paul, W. E. 1 Thorbecke, G. Jeanette 1 Siskind, G. W. 1 Benacerraf, B. 1,2,3; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland  2: Department of Medicine and Pathology, New York University of Medicine, New York, U.S.A.  3: Department of Medicine, Cornell University Medical College, New York, N.Y., U.S.A.; Source Info: Jul69, Vol. 17 Issue 1, p85; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNIZATION; Subject Term: RABBITS as laboratory animals; Subject Term: ADMINISTRATION of drugs; Subject Term: CELLS; Subject Term: IMMUNOLOGY; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simmons, William L.
AU  - Tyler, Forrest B.
T1  - LENGTH OF HOSPITALIZATION AS A FUNCTION OF PATIENTS' CONCEPTIONS OF THERAPISTS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1969/07//
VL  - 25
IS  - 3
M3  - Article
SP  - 332
EP  - 338
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article presents a study, which investigates whether differences among patients in relative degree of concern with task vs. personal characteristics of therapists are related to length of hospital stay. The results indicated that patients who conceptualized therapists more in terms of task activities and less in terms of personal characteristics spent significantly less time in the hospital arid had a significantly higher discharge rate than patients who conceptualized therapists more in terms of personal characteristics and less in terms of task activities.
KW  - PSYCHIATRIC hospitals -- Length of stay
KW  - PSYCHOTHERAPIST & patient
KW  - PSYCHOTHERAPY patients
KW  - MENTAL illness
KW  - PSYCHIATRIC hospitals -- Admission & discharge
KW  - MEDICAL personnel & patient
N1  - Accession Number: 15903638; Simmons, William L. 1 Tyler, Forrest B. 2; Affiliation:  1: American Psychological Association.  2: National Institute of Mental Health.; Source Info: Jul1969, Vol. 25 Issue 3, p332; Subject Term: PSYCHIATRIC hospitals -- Length of stay; Subject Term: PSYCHOTHERAPIST & patient; Subject Term: PSYCHOTHERAPY patients; Subject Term: MENTAL illness; Subject Term: PSYCHIATRIC hospitals -- Admission & discharge; Subject Term: MEDICAL personnel & patient; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Frank, M. M.
AU  - Humphrey, J. H.
T1  - Spontaneous Re-Aggregation of IgM Subunits and Restoration of Antibody Activity After Reduction and Alkylation of Rabbit Anti-Forssman Antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1969/08//
VL  - 17
IS  - 2
M3  - Article
SP  - 237
EP  - 247
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Highly purified rabbit IgM anti-Forssman antibody, after reduction in dilute solution with 2-mercaptoethanol and alkylation with iodoacetamide, showed no diminution and often some increase in haemagglutination of sheep erythrocytes. The capacity to cause complement dependent lysis was, however, destroyed. It is shown that despite reduction and alkylation reaggregation of the subunits occurs to a variable extent producing non-covalently bound aggregates with S values ranging from 7 to more than 20. The aggregates can bind specifically to and agglutinate erythrocytes with greater effectiveness as their size increases. This spontaneous re-aggregation is not prevented by the presence of gelatin, but fails to occur when the IgM antibody is reduced in the presence of a variety of other proteins. The effect of extraneous proteins is evident only when they are present at the time of reduction or are added within 10–15 minutes. It is suggested that following rupture of the interchain disulphide bonds, the IgM molecule can undergo a complex, time-dependent rearrangement into new stable forms which retain combining site activity but do not involve covalent bonds. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNOGLOBULIN G
KW  - IMMUNOGLOBULINS
KW  - CHEMICAL reduction
KW  - ALKYLATION
KW  - IMMUNOLOGY
KW  - PROTEOMICS
N1  - Accession Number: 13355393; Frank, M. M. 1,2 Humphrey, J. H. 3; Affiliation:  1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland  2: Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.  3: National Institute, Medical Research, Mill Hill, London; Source Info: Aug69, Vol. 17 Issue 2, p237; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOGLOBULINS; Subject Term: CHEMICAL reduction; Subject Term: ALKYLATION; Subject Term: IMMUNOLOGY; Subject Term: PROTEOMICS; Number of Pages: 11p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Adler, W. H.
AU  - Curry, Jean H.
AU  - Smith, R. T.
T1  - Immunoglobulin Peptidc Chain Synthesis in the Newborn Rabbit.
JO  - Immunology
JF  - Immunology
Y1  - 1969/09//
VL  - 17
IS  - 3
M3  - Article
SP  - 457
EP  - 468
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Lymphoid tissue from newborn rabbits was examined using fluorochrome conjugated goat antisera to rabbit γ, μ and α heavy chain and mixed light chain. Unimmunizcd newborn rabbits examined at intervals up to 20 days of age revealed a very low background of approximately one in 105 cells which stained with either the anti-μ, anti-γ or anti-L chain reagents. Newborn rabbits, immunized intrapcritoncally on the day of birth with S. paralyphi B (4, 5, 12:b), showed a 1000-fold increase in the number of stained cells; μ heavy chain containing cells were found 16 hours after immunization, and γ heavy chain containing cells were found 20 hours after immunization in the rabbit spleen tissue. The numbers of μ containing cells and γ containing cells were approximately equal at 5 days of age in tile immunized groups. No α heavy chain containing cells were found in any of tile rabbits studied. All cells which stained with the anti-μ or γ heavy chain reagent were also stained with the anti-light chain reagent. The cellular response of the immunized newborn rabbits could be inhibited by passive antibody to S. paralyphi B, either given at the time of immunization, or passively acquired from the doc. Specificity of inhibition was indicated by the failure of sheep red blood cells (SRBG) stroma to be inhibited in animals so suppressed. The range of cellular morphology of the γ chain containing and the μ chain containing cells was indistinguishable. The earliest cell to be stained with either anti-γ or anti-μ was a large blast-like cell with a thin rim of cytoplasm and a large nucleus. A full range of forms between this and typical plasma cells appeared later in each case. These findings present a paradox since γG antibody to this antigen does not appear in the serum of stroll animals following γM class in the usual sequence characteristic of adult animals. Possible explanations of this paradox arc explored. [ABSTRACT FROM AUTHOR]
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KW  - ANTIGENS
KW  - IMMUNIZATION
KW  - IMMUNITY
KW  - IMMUNOGLOBULINS
KW  - PLASMA cells
KW  - IMMUNOLOGY
N1  - Accession Number: 14545579; Adler, W. H. 1,2 Curry, Jean H. 1 Smith, R. T. 1; Affiliation:  1: Department of Pathology, University of Florida, School of Medicine, Gainesville, Florida 32601  2: Research Fellow, Immunology (National Institute of Allergy and Infectious Diseases Training Grant 5T1-A1-128-06); Source Info: Sep69, Vol. 17 Issue 3, p457; Subject Term: ANTIGENS; Subject Term: IMMUNIZATION; Subject Term: IMMUNITY; Subject Term: IMMUNOGLOBULINS; Subject Term: PLASMA cells; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - McIntire, K. R.
AU  - Princler, G. L.
T1  - Prolonged Adjuvant Stimulation in Germ-Free BALB/c Mice: Development of Plasma Cell Neoplasia.
JO  - Immunology
JF  - Immunology
Y1  - 1969/09//
VL  - 17
IS  - 3
M3  - Article
SP  - 481
EP  - 487
PB  - Wiley-Blackwell
SN  - 00192805
AB  - BALB/c mice develop a high incidence (60–80 per cent) of plasma cell tumour (PCT) following the introduction of mineral oil (MO) into the peritoneal cavity. Germ-free (GF) mice have a less developed lymphoreticular system, including a decreased number of plasma cells, than their conventional (CONV) counterparts. When GF BALB/c mice were injected i.p. with mineral oil they failed to develop the expected incidence of PCT. Only two of thirty-three GF mice (6 per cent) developed PCT, while twenty-four of thirty-one ex-GF (77 per cent) and twenty-eight of forty CONV BALB/c (70 per cent) developed PCT. The ex-GF and CONV mice had average times for PCT diagnosis of 11.3 and 11.5 months, but both GF tumours were discovered 18 months after mineral oil injection. Three groups of GF mice recieved three different sterile protein antigens along with MO and no PCT developed in these mice; in the GF group receiving MO along, both PCT arose. The GF mice in this experiment did develop a high incidence (80 per cent) of lymphoreticular neoplasms of a type more primitive than PCT. This experiment suggests the importance of microbial flora in the development and differentiation of the plasma cells which respond to a carcinogenic stimulus in a genetically susceptible host. [ABSTRACT FROM AUTHOR]
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KW  - PLASMA cells
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - MINERAL oils
KW  - IMMUNOLOGY
N1  - Accession Number: 14545586; McIntire, K. R. 1 Princler, G. L. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep69, Vol. 17 Issue 3, p481; Subject Term: PLASMA cells; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: MINERAL oils; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyatt, Richard
AU  - Tursky, Bernard
T1  - SKIN POTENTIAL LEVELS IN RIGHT- AND LEFT-HANDED MALES.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1969/09//
VL  - 6
IS  - 2
M3  - Article
SP  - 133
EP  - 137
SN  - 00485772
AB  - From twelve left-handed and twelve right-handed males, skin potential levels were recorded simultaneously from both sides of the body. In both groups significantly higher skin potential levels were found on the right side. Unilateral stimuli and handedness did not unilaterally affect maximum response level. [ABSTRACT FROM AUTHOR]
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KW  - SKIN
KW  - HANDEDNESS
KW  - MALES
KW  - PSYCHOPHYSIOLOGY
N1  - Accession Number: 11049682; Wyatt, Richard 1 Tursky, Bernard 2; Affiliation:  1: National Institute of Mental Health, Bethesda  2: Massachusetts Mental Health Center; Source Info: Sep1969, Vol. 6 Issue 2, p133; Subject Term: SKIN; Subject Term: HANDEDNESS; Subject Term: MALES; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 5p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Wilcox, Michael
T1  - υ-Glutamyl Phosphate Attached to Glutamine-Specific tRNA.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1969/12/31/
VL  - 11
IS  - 3
M3  - Article
SP  - 405
EP  - 412
PB  - Wiley-Blackwell
SN  - 00142956
AB  - B. subtilis Gln-tRNA formation, in vitro, involves the initial acceptance of glutamic acid by tRNAGln to form a missense Glu-tRNGln intermediate which is converted to Gln-tRNA by a subsequent amidation step, catalyzed by a specific amido-transferase, and requiring divalent cations, ATP, and L-glutamine or L-asparagine as amide donor. This reaction is associated with stoichiometric cleavage of glutamine and ATP to yield glutamic acid and Pi, respectively. Amidation proceeds via the formation of an activated intermediate which is shown to be γ-phospho-Glu-tRNAGln (P-γ-Glu-tRNAGln). P-γ-Glu-tRNAGln, bound to amido-transfcrase, is detected following incubation in the absence of amide donor. Subsequent addition of L-glutamine to the system leads to the rapid toss of the phosphate moiety from the intermediate concomitantly with the formation of Gln-tRNA, which is released from the enzyme. Consequences of the pathway, if it is duplicated in vivo, are the separation of the synthesis of glutamine destined for protein from that of free glutamine and, further, the coupling of the synthesis of the ammo acid with that, of protein. These implications are discussed with regard to their bearing on possible functions of the pathway. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUTAMYL-tRNA synthetase
KW  - GLUTAMIC acid
KW  - TRANSFER RNA
KW  - ADENOSINE triphosphate
KW  - TRANSFERASES
KW  - AMIDES
KW  - CATIONS
N1  - Accession Number: 13441939; Wilcox, Michael 1; Affiliation:  1: Laboratory of Biochemical Genetics, National Heart Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 1969, Vol. 11 Issue 3, p405; Subject Term: GLUTAMYL-tRNA synthetase; Subject Term: GLUTAMIC acid; Subject Term: TRANSFER RNA; Subject Term: ADENOSINE triphosphate; Subject Term: TRANSFERASES; Subject Term: AMIDES; Subject Term: CATIONS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Coe, J.E.
T1  - The Immune Response in the Hamster II. STUDIES ON IgM.
JO  - Immunology
JF  - Immunology
Y1  - 1970/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 223
EP  - 236
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Hamster IgM has been isolated and characterized. The protein possessed unique antigenic determinants but also shared common determinants with the 7Sγ1- and 7Sγ2-globulin classes. These shared determinants were present on the F(ab')2 and Fab fragments of 7Sγ2-globulin. The rapidly sedimenting (S20,w = 20.7) IgM was dissociated into slowly sedimenting (≈ 7S) units after reduction and alkylation. Specific antibody formation in the IgM and IgG (7Sγ1-globulin) classes appeared at similar times after immunization with protein antigens, although IgM antibody was only detectable for a short period. After immunization with antigen in Freund's adjuvant, the serum concentration of IgM increased and remained at an elevated level even after disappearance of antibody to the immunizing antigen. Injection of adjuvant alone also increased the concentration of serum IgM, particularly after intraperitoneal administration of Freund's incomplete adjuvant. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNOGLOBULIN M
KW  - IMMUNE response
KW  - ANTIGENIC determinants
KW  - HAMSTERS
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGICAL adjuvants
N1  - Accession Number: 13358132; Coe, J.E. 1; Affiliation:  1: United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Feb70, Vol. 18 Issue 2, p223; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNE response; Subject Term: ANTIGENIC determinants; Subject Term: HAMSTERS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGICAL adjuvants; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stashak, P. W.
AU  - Baker, P. J.
AU  - Roberson, B. S.
T1  - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice I. ASSAY OF NEUTRALIZING ANTIBODY BY A 50 PER CENT NEUTRALIZATION METHOD.
JO  - Immunology
JF  - Immunology
Y1  - 1970/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 295
EP  - 305
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The experimental conditions most suitable for use in the assay of serum neutralizing antibody specific for bacteriophage φX174 by a 50 per cent neutralization method were investigated. Although assays conducted at 37° more readily revealed the presence of background neutralizing activity in the serum of non-immunized germ-free and conventionally reared mice, assays performed at 4° were more suitable for use in detecting the development of newly synthesized neutralizing antibody. In definitive experiments, the SD50 values obtained, i.e. the reciprocal of the serum dilution producing 50 per cent neutralization of added bacteriophage, were found to be directly proportional to the concentration of neutralizing antibody present in serum. The magnitude of the SD50 values obtained suggests that the procedure may be employed advantageously for the detection of very small amounts of antibody and in studies dealing with the kinetics of the antibody response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - BACTERIOPHAGES
KW  - IMMUNOGLOBULINS
KW  - MICE
KW  - IMMUNE serums
KW  - IMMUNOLOGY
N1  - Accession Number: 13358436; Stashak, P. W. 1 Baker, P. J. 2 Roberson, B. S. 3; Affiliation:  1: Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases  2: National Institutes of Health, Bethesda, Maryland 20014, U.S.A.  3: Department of Microbiology University of Maryland, College Park, Maryland, U. S. A.; Source Info: Feb70, Vol. 18 Issue 2, p295; Subject Term: IMMUNE response; Subject Term: BACTERIOPHAGES; Subject Term: IMMUNOGLOBULINS; Subject Term: MICE; Subject Term: IMMUNE serums; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stashak, P. W.
AU  - Baker, P. J.
AU  - Roberson, B. S.
T1  - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice II. KINETICS OF THE SERUM ANTIBODY RESPONSE FOLLOWING PRIMARY IMMUNIZATION.
JO  - Immunology
JF  - Immunology
Y1  - 1970/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 307
EP  - 317
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The kinetics of the serum antibody response to various amounts of bacteriophage φX174 were compared in germ-free and conventionally reared mice using a 50 per cent neutralization procedure for the assay of neutralizing antibody. Ten- and 100-fold increases in the amount of φX174 used to immunize resulted in seven and ten-fold increases, respectively, in the amount of antibody produced in conventionally reared mice; however, the same amounts of antigen produced only 1.3- and 1.9-fold increases in germ-free mice. Greater SD50 values, i.e. the reciprocal of the highest dilution of serum which neutralized 50 per cent of the added bacteriophage, were obtained in conventionally reared than germ-flee mice during the later stages of the antibody response; no other significant differences were noted in the kinetics of the response produced in both groups of animals immunized with high doses of antigen. However, neutralizing antibody was produced at a more rapid rate and in larger amounts in germ-free than conventionally reared mice immunized with a low dose of antigen. Regardless of the amount of antigen used to immunize, the time of onset of antibody formation was essentially the same (32-35 hours after injection) in both groups of mice. Conventionally reared mice eliminated antigen at half the rate observed in germ-free mice similarly immunized with high doses of φX174, but with low doses of antigen, no significant differences in elimination rate were noted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - BACTERIOPHAGES
KW  - IMMUNOGLOBULINS
KW  - MICE
KW  - IMMUNE serums
KW  - IMMUNOLOGY
N1  - Accession Number: 13358442; Stashak, P. W. 1 Baker, P. J. 2 Roberson, B. S. 3; Affiliation:  1: Laboratory of Microbiol Immunity, National Institute of Allergy and Infectious Diseases  2: National Institutes of Health, Bethesda, Maryland 20014, U.S.A.  3: Department of Microbiology University of Maryland, College Park, Maryland, U.S.A.; Source Info: Feb70, Vol. 18 Issue 2, p307; Subject Term: IMMUNE response; Subject Term: BACTERIOPHAGES; Subject Term: IMMUNOGLOBULINS; Subject Term: MICE; Subject Term: IMMUNE serums; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levine, S.
AU  - Hoenig, E. M.
AU  - Kies, Marian W.
T1  - ALLERGIC ENCEPHALOMYELITIS: IMMUNOLOGICALLY SPECIFIC INHIBITION OF CELLULAR PASSIVE TRANSFER BY ENCEPHALITOGENIC BASIC PROTEINS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1970/04//
VL  - 6
IS  - 4
M3  - Article
SP  - 503
EP  - 517
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Passive transfer of experimental allergic encephalomyelitis (EAE) was performed with lymph node cells from donor rats immunized with spinal cord or purified encephalitogenic basic protein and any of several adjuvant combinations. Transfer was inhibited by injection of recipients with the brain basic protein. Basic proteins from rat and guinea-pig CNS inhibited transfer from donors immunized with rat or guinea-pig spinal cord or basic protein. Monkey basic protein inhibited transfer from donors immunized with monkey or human cord. There was only partial cross-inhibition between rodent and primate groups. The inhibition was organ specific in that basic proteins from lung, spleen and adrenal did not inhibit transfer of EAE. Furthermore, transfer of adrenalitis from donors immunized with adrenal tissue was inhibited by adrenal extracts but not by CNS basic protein. Pertussis and typhoid vaccines injected into recipients inhibited transfer of either EAE or adrenalitis. This non-specific inhibition was also demonstrated after simultaneous transfer of both EAE and adrenalitis, whereas CNS basic protein eliminated only EAE in such recipients. Inhibition was complete in experiments terminated one day after transfer. In  longer experiments, inhibition lasted only 3 or 4 days. Basic protein was rapidly cleared from the blood. Neither spleen nor adrenals were necessary for its action. Brain basic protein prevented the interaction between encephalitogenic cells and the target Organ by an immunologically specific mechanism which may be a type of desensitization. The inhibition could not be reproduced in vitro. Bioassay and radioactive tracers revealed that basic protein bound non-specifically to living or dead lymph node cells in vitro. The effects of incubation could be accounted for by this non-specific carry-over of basic protein into the recipients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENCEPHALOMYELITIS
KW  - LYMPH
KW  - DEMYELINATION
KW  - PROTEINS
KW  - CENTRAL nervous system -- Diseases
KW  - LYMPHOID tissue
N1  - Accession Number: 14587029; Levine, S. 1,2 Hoenig, E. M. 1,2 Kies, Marian W. 1,2; Affiliation:  1: Pathology Department, New York Medical College Center for Chronic Disease. Bird S. Coler Hospital, Welfare Island, New York, New York.  2: Section of Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland.; Source Info: Apr70, Vol. 6 Issue 4, p503; Subject Term: ENCEPHALOMYELITIS; Subject Term: LYMPH; Subject Term: DEMYELINATION; Subject Term: PROTEINS; Subject Term: CENTRAL nervous system -- Diseases; Subject Term: LYMPHOID tissue; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Colten, H.R.
AU  - Borsos, T.
AU  - Rapp, H.J.
T1  - Isoelectric Focusing of Human and Guinea-Pig C2: Polymorphism of Guinea-Pig C2.
JO  - Immunology
JF  - Immunology
Y1  - 1970/04//
VL  - 18
IS  - 4
M3  - Article
SP  - 467
EP  - 472
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The isoelectric point (pI) of human and guinea-pig C2 was determined by electrofocusing. The results showed that human C2 and C2 of some guinea-pigs had a pi of approximately pH 5-5-5·6; in some guinea-pig sera C2 activity was resolved into two fractions, one with a pi of about 5·2 and the other of about 5·5. The data suggest the possibility that guinea-pig C2 may exist in at least two allotypic forms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPLEMENT (Immunology)
KW  - BLOOD proteins
KW  - ISOELECTRIC focusing
KW  - GUINEA pigs
KW  - IMMUNOLOGY
KW  - SEPARATION (Technology)
N1  - Accession Number: 13358591; Colten, H.R. 1 Borsos, T. 1 Rapp, H.J. 1; Affiliation:  1: Biology Branch and the Immunology Section, Biology Branch National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Apr70, Vol. 18 Issue 4, p467; Subject Term: COMPLEMENT (Immunology); Subject Term: BLOOD proteins; Subject Term: ISOELECTRIC focusing; Subject Term: GUINEA pigs; Subject Term: IMMUNOLOGY; Subject Term: SEPARATION (Technology); NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bell, Richard Q.
T1  - SLEEP CYCLES AND SKIN POTENTIAL IN NEWBORNS STUDIED WITH A SIMPLIFIED OBSERVATION AND RECORDING SYSTEM.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1970/05//
VL  - 6
IS  - 6
M3  - Article
SP  - 778
EP  - 786
SN  - 00485772
AB  - A simple visual observation system, supplemented by measurement of skin potential, was devised for developmental studies of sleep cycles in settings where multiple electrode placement is not practicable. The findings replicated essential features of quiet and active sleep cycles which had been reported previously to exist against the background of decreasing level of physiological arousal, as sleep proceeds. Twelve newborns showed approximately one-half of their interfeeding sleeping time in the rapid eye movement stage of sleep. Skin potential rapidly declined from the waking level, continued to decrease in level throughout sleep, increased in variability during REM sleep, and increased in level at the second waking period. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GALVANIC skin response
KW  - REFLEXES
KW  - SLEEP
KW  - NEWBORN infants
KW  - ELECTROPHYSIOLOGY
KW  - Newborns.
KW  - Skin potential
KW  - Sleep
N1  - Accession Number: 11049746; Bell, Richard Q. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: May1970, Vol. 6 Issue 6, p778; Subject Term: GALVANIC skin response; Subject Term: REFLEXES; Subject Term: SLEEP; Subject Term: NEWBORN infants; Subject Term: ELECTROPHYSIOLOGY; Author-Supplied Keyword: Newborns.; Author-Supplied Keyword: Skin potential; Author-Supplied Keyword: Sleep; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-8986.ep11049746
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moss, Howard A.
AU  - Robson, Kenneth S.
T1  - THE RELATION BETWEEN THE AMOUNT OF TIME INFANTS SPEND AT VARIOUS STATES AND DEVELOPMENT OF VISUAL BEHAVIOR.
JO  - Child Development
JF  - Child Development
Y1  - 1970/06//
VL  - 41
IS  - 2
M3  - Article
SP  - 509
EP  - 517
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 10400249; Moss, Howard A. 1 Robson, Kenneth S. 1; Affiliation:  1: National Institute of Mental Health; Source Info: Jun1970, Vol. 41 Issue 2, p509; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Paul, W.E.
AU  - Siskind, G.W.
T1  - Hapten Specificity of Cellular Immune Responses as Compared with the Specificity of Serum Anti-hapten Antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1970/06//
VL  - 18
IS  - 6
M3  - Article
SP  - 921
EP  - 930
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Comparative specificity data have been presented for the interaction of anti-hapten antibody with a series of structurally related haptens and for the stimulation by hapten-guinea pig albumin (GPA) conjugates of DNA synthesis in lymph node cell cultures from guinea pigs immunized with a given conjugate. A good correlation in the specificity of serum anti-hapten antibody and in the specificity of stimulation of DNA synthesis has been demonstrated. Thus, mutual serologic and stimulatory cross-reactivity exist between the aminocaproates and GPA conjugates of the p-iodophenysulfonyl and toluenesulfonyl groups. Poor or undetectable serologic and stimulatory cross reactivity exist in the other combinations tested. The data is consistent with the notion that the interaction of antigen with an antibody-like cellular receptor is crucial to the elicitation of cellular immune responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAPTENS
KW  - IMMUNE response
KW  - CELLULAR immunity
KW  - ALBUMINS
KW  - ANTIGENS
KW  - IMMUNOLOGY
N1  - Accession Number: 13359421; Paul, W.E. 1 Siskind, G.W. 1; Affiliation:  1: Laboratory of Immunology, Nationai Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Medicine, Cornell University College of Medicine, New York, New York 10021; Source Info: Jun70, Vol. 18 Issue 6, p921; Subject Term: HAPTENS; Subject Term: IMMUNE response; Subject Term: CELLULAR immunity; Subject Term: ALBUMINS; Subject Term: ANTIGENS; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ugel, Arthur R.
AU  - Idler, William
T1  - STRATUM GRANULOSUM: DISSECTION FROM CATTLE HOOF EPIDERMIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1970/11//
VL  - 55
IS  - 5
M3  - Article
SP  - 350
EP  - 353
SN  - 0022202X
AB  - A hairless area of epidermis is present on the posterior aspect of cattle hooves. When this area is excised the cut surfaces reveal three thick and well-demarcated cellular layers: 1) a glassy-clear stratum corneum; 2) the underlying epidermal cell layers; 3) the dermis. Microscopically, the stratum granulosum of this tissue averages 20 cells in thickness and is free of hair follicles, sebaceous and sweat glands. In view of the thickness of these cellular layers and the sharp demarcation between the stratum corneum and granular cell layers, it is possible by fine dissection to obtain sheets of fresh tissue which contain large amounts of keratohyalin. Such preparations are contaminated with variable amounts of cells from the stratum malpighii and dermal ridges, and small amounts of cornified and basal cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - SKIN
KW  - TISSUES
KW  - SWEAT glands
KW  - HAIR follicles
KW  - CELLS
N1  - Accession Number: 12260280; Ugel, Arthur R. 1 Idler, William 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland; Source Info: Nov70, Vol. 55 Issue 5, p350; Subject Term: EPIDERMIS; Subject Term: SKIN; Subject Term: TISSUES; Subject Term: SWEAT glands; Subject Term: HAIR follicles; Subject Term: CELLS; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12260280
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yuspa, Stuart H.
AU  - Morgan, David L.
AU  - Walker, Ruby J.
AU  - Bates, Richard R.
T1  - THE GROWTH OF FETAL MOUSE SKIN IN CELL CULTURE AND TRANSPLANTATION TO F1 MICE.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1970/12//
VL  - 55
IS  - 6
M3  - Article
SP  - 379
EP  - 389
SN  - 0022202X
AB  - A method for the monolayer culture of fetal mouse skin cells and the behavior of primary cultures have been described. The early cultures consist of discrete colonies of epidermoid cells with individual fibroblasts scattered between these foci. The cell colonies begin to produce a material which may be keratin by the third <em>in vitro day</em>. After one week <em>in vitro</em> the majority of epidermoid foci have degenerated and the cultures consist largely of elongated rapidly multiplying cells. When cells from cultures <em>in vitro</em> five days or less are transplanted back to the panniculus carnosus of F1 hosts, donor skin grows. This skin is hyperplastic but contains normal appendages and produces hair. These grafts have remained recognizable and stable for over four months. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MICE
KW  - SKIN
KW  - CELL culture
KW  - CELLS
KW  - FIBROBLASTS
KW  - HAIR
N1  - Accession Number: 12260498; Yuspa, Stuart H. 1 Morgan, David L. 1 Walker, Ruby J. 1 Bates, Richard R. 1; Affiliation:  1: Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014.; Source Info: Dec70, Vol. 55 Issue 6, p379; Subject Term: MICE; Subject Term: SKIN; Subject Term: CELL culture; Subject Term: CELLS; Subject Term: FIBROBLASTS; Subject Term: HAIR; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1523-1747.ep12260498
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BUCHSBAUM, MONTE
AU  - STEVENS, S. S.
T1  - Neural Events and Psychophysical Law.
JO  - Science
JF  - Science
Y1  - 1971/04/30/
VL  - 172
IS  - 3982
M3  - Article
SP  - 502
EP  - 502
SN  - 00368075
N1  - Accession Number: 85104565; BUCHSBAUM, MONTE 1; STEVENS, S. S. 2; Affiliations: 1: Unit on Psychophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Harvard University, Cambridge, Massachusetts 02138; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p502; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LIBET, B.
AU  - WEIGHT, FoRRLST F.
T1  - Inactivation of Potassium Conductance in Slow Postsynaptic Excitation.
JO  - Science
JF  - Science
Y1  - 1971/04/30/
VL  - 172
IS  - 3982
M3  - Article
SP  - 503
EP  - 504
SN  - 00368075
N1  - Accession Number: 85104567; LIBET, B. 1; WEIGHT, FoRRLST F. 2; Affiliations: 1: Department of Physiology, University of California, San Francisco 94122; 2: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p503; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Murphy, D. L.;
AU  - Goodwin, F. K.;
AU  - Bunney, W. E., Jr.;
T1  - Leukocytosis during lithium treatment
CT  - Leukocytosis during lithium treatment
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1971/05/01/
VL  - 127:11
IS  - May
SP  - 1559
EP  - 1561
SN  - 0002953X
AD  - Section on Psychiatry, Laboratory of Clinical Sciences, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 8-3095; Language: English; Chemical Name: Lithium--7439-93-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium; References: 20; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2  - An increase in circulating leukocytes accompanied lithium treatment in 28 consecutively studied manic-depressive patients. Acutely manic patients showed the most marked changes and maintained leukocyte counts of 10,000 to 14,000 during the first 2 to 4 weeks of lithium administration. Leukocyte counts returned to pre-lithium levels within one week after discontinuation of the drug. In 11 patients receiving lithium for longer periods, the elevation in white cell count persisted throughout treatment.
KW  - Lithium--adverse reactions-;
KW  - Drugs, adverse reactions--lithium--leukocytosis, in manic-depressive patients;
KW  - Psychotherapeutic agents--lithium--adverse reactions, leukocytosis in manic-depressive patients;
KW  - Toxicity--lithium--leukocytosis, in manic-depressive patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Henkin, R. I.;
T1  - Griseofulvin and dysgeusia: implications?
CT  - Griseofulvin and dysgeusia: implications?
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/05/01/
VL  - 74
IS  - May
SP  - 795
EP  - 796
SN  - 00034819
AD  - Section on Neuroendocrinology, Experimental Therapeutics Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 8-4384; Language: English; Trade Name: Oxyphedrin--Ildamen; Generic Name: Oxyfedrine; Oxyfedrine; Chemical Name: Griseofulvin--126-07-8 Clofibrate--637-07-0 Lincomycin--154-21-2 Penicillamine--52-67-5 Phenindione--83-12-5 Oxyfedrine--15687-41-9; References: 9; Publication Type: Letters and Comments; Journal Coden: AIMEAS; Section Heading: Toxicity; Abstract Author: Judith A. Kepler
N2  - Hypogeusia (decreased taste acuity) or dysgeusia (unpleasant or altered taste sensation) are important complications of drug therapy that have often been overlooked or disregarded by physicians. Hypogeusia has been reported after administration of clofibrate, lincomycin, D-penicillamine, and 5-mercaptopyridoxal. Altered taste acuity has been reported after administration of griseofulvin, phenindione, oxyphedrin (oxyfedrine) hydrochloride (Ildamen), acetyl sulfosalicylic acid, and several tranquilizers.
KW  - Griseofulvin--toxicity-;
KW  - Clofibrate--toxicity-;
KW  - Lincomycin--toxicity-;
KW  - Penicillamine--toxicity-;
KW  - Mercaptopyridoxal--5--;
KW  - Phenindione--toxicity-;
KW  - Oxyfedrine--hydrochloride-;
KW  - Acetyl sulfosalicylic acid--toxicity-;
KW  - Toxicity--drugs--hypogeusia or dysgeusia, discussion;
KW  - Tranquilizers--toxicity--altered taste acuity;
KW  - Taste--drugs--with taste effects as complications;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Yamamoto, R. S.;
AU  - Weisburger, J. H.;
AU  - Weisburger, E. K.;
T1  - Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors
CT  - Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1971/05/01/
VL  - 31
IS  - May
SP  - 483
EP  - 486
SN  - 00085472
AD  - Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 9-2654; Language: English; References: 16; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Abstract Author: Jimmie L. Hall
N2  - This article reports the effects of various microsomal enzyme inducers (chlordane, phenobarbital, \b/-naphthoflavone, phenothiazine, and proadifen) and of metabolic inhibitors (dactinomycin, puromycin, and cycloheximide) on urethan carcinogenesis in mice.
KW  - Urethan--carcinogenesis-;
KW  - Carcinogens--urethan--carcinogenesis, in mice, effects of microsomal enzyme inducers and of metabolic inhibitors;
KW  - Toxicity--urethan--carcinogenesis, in mice, effects of microsomal enzyme inducers and of metabolic inhibitors;
KW  - Drugs--effects--of microsomal enzyme inducers and of metabolic inhibitors, on urethan carcinogenesis, in mice;
KW  - Enzymes--inducers--microsomal, and metabolic inhibitors, effects on urethan carcinogenesis, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Milner, John E.
T1  - <em>IN VITRO</em> LYMPHOCYTE RESPONSE IN CONTACT HYPERSENSITIVITY II.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1971/05//
VL  - 56
IS  - 5
M3  - Article
SP  - 349
EP  - 352
SN  - 0022202X
AB  - Guinea pigs were sensitized to one of two contact allergens: diatrofluorobenzene (DNFB) and paraphylenediamine (PDA). Sensitization was accomplished by foot-pad injections of the uncojugated bapten in Freud's complete adjuvan. Lymphocytes from animals with contact hypersesitivity to DNFB or PDA were cultured <em>in vitro</em> with conjugates of guinea pig epidermal proteins with DNFB or PDA. Responses to these antigens as measured by incorporation of tritiated thymidine into DNA, indicated that lymphocyte transformation <em>in vitro</em> can distinguish between sensitivity to either of these allergens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALLERGY
KW  - IMMUNOGLOBULINS
KW  - LYMPHOCYTES
KW  - DNA
KW  - THYMIDINE
KW  - GUINEA pigs
N1  - Accession Number: 12261204; Milner, John E. 1; Affiliation:  1: National Cancer Institute Research Career, Development Awardce, No. 1 K4 CA 33563-01, MB.; Source Info: May71, Vol. 56 Issue 5, p349; Subject Term: ALLERGY; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: DNA; Subject Term: THYMIDINE; Subject Term: GUINEA pigs; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12261204
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simon, R. M.
T1  - STATIONARY PROPERTIES OF A TWO-ECHELON INVENTORY MODEL FOR LOW DEMAND ITEMS.
JO  - Operations Research
JF  - Operations Research
Y1  - 1971/05//May/Jun71
VL  - 19
IS  - 3
M3  - Article
SP  - 761
EP  - 773
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - This paper considers a two-echelon inventory model for consumable or repairable parts in which the first-echelon facilities use one-for-one replenishment policies and the second-echelon facility uses a continuousreview (s, ,S) policy. Repair may be accomplished at all facilities. Repair and transportation times are assumed to be deterministic, and the failure processes that generate demands are assumed to be Poisson. The paper derives exact expressions for the stationary distributions of stock on hand, stock in repair, and backlogged demand at each facility, and indicates how these expressions may be utilized for optimization purposes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Operations Research is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONSUMER goods
KW  - INVENTORIES
KW  - RETROFITTING
KW  - DEMAND (Economic theory)
KW  - DOWNTIME (Systems)
KW  - MATHEMATICAL optimization
N1  - Accession Number: 8602270; Simon, R. M. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland.; Issue Info: May/Jun71, Vol. 19 Issue 3, p761; Thesaurus Term: CONSUMER goods; Thesaurus Term: INVENTORIES; Thesaurus Term: RETROFITTING; Thesaurus Term: DEMAND (Economic theory); Thesaurus Term: DOWNTIME (Systems); Thesaurus Term: MATHEMATICAL optimization; NAICS/Industry Codes: 532299 All Other Consumer Goods Rental; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Pfefferbaum, Adolf
AU  - Buchsbaum, Monte
AU  - Gips, James
T1  - ENHANCEMENT OF THE AVERAGE EVOKED RESPONSE TO TONE ONSET AND CESSATION.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1971/05//
VL  - 8
IS  - 3
M3  - Article
SP  - 332
EP  - 339
SN  - 00485772
AB  - Auditory average evoked responses (AERs) produced by tone onset (ON responses) and tone cessation (OFF responses) were studied in 14 normal adult subjects. When short (500 msec) tone bursts were presented widely spaced (2500 msec between tones), ON responses were large, in contrast to OFF responses, which were less than one-third their size. But when long tones (2500 msec) were succeeded by brief (500 msec) silences, OFF and ON responses were comparable in size. In addition to this observed effect of the ratio of the percent of time the tone was on to the percent of time the tone was off, control experiments suggested that increased duration of preceding interval, unexpectancy of stimulus occurrence, and decreased mean frequency of stimulus presentation all increase the amplitude of both OFF and ON responses. OFF responses were found to be more sensitive to stimulus spacing effects than ON responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUDITORY evoked response
KW  - AUDITORY perception
KW  - EVOKED potentials (Electrophysiology)
KW  - FIGURE-ground perception
KW  - PERCEPTION
KW  - COGNITION
KW  - auditory evoked response
KW  - figure-ground reversal.
KW  - off response
KW  - stimulus expectancy
KW  - stimulus frequency
N1  - Accession Number: 11051057; Pfefferbaum, Adolf 1 Buchsbaum, Monte 2 Gips, James 2; Affiliation:  1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda.  2: Unit of Psychophysiology, Laboratory of Psychology National Institute of Mental Health, Bethesda.; Source Info: May1971, Vol. 8 Issue 3, p332; Subject Term: AUDITORY evoked response; Subject Term: AUDITORY perception; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: FIGURE-ground perception; Subject Term: PERCEPTION; Subject Term: COGNITION; Author-Supplied Keyword: auditory evoked response; Author-Supplied Keyword: figure-ground reversal.; Author-Supplied Keyword: off response; Author-Supplied Keyword: stimulus expectancy; Author-Supplied Keyword: stimulus frequency; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-8986.ep11051057
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schall, G.;
AU  - Zeiger, L.;
AU  - DiChiro, G.;
AU  - Briner, W.;
AU  - Matsen, F.;
T1  - Clinical comparison of two Tc 99\LC/m\UC/ tracers for brain scanning: pertechnetate vs labeled albumin
CT  - Clinical comparison of two Tc 99\LC/m\UC/ tracers for brain scanning: pertechnetate vs labeled albumin
JO  - Radiology
JF  - Radiology
Y1  - 1971/05/01/
VL  - 99
IS  - May
SP  - 361
EP  - 368
AD  - National Institutes of Health, Department of Nuclear Medicine, Clinical Center, Building 10, Rm 1B53, Bethesda, MD 20014, USA
N1  - Accession Number: 10-2853; Language: English; Chemical Name: Technetium Tc 99m albumin--0 Technetium Tc 99m pertechnetate--23288-61-1; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals technetium Tc 99m pertechnetate; References: 14; Journal Coden: RADLAX; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Technetium Tc 99m pertechnetate and Tc 99m albumin were injected at different times into 60 patients for radionuclide brain studies. In all, 12 out of 20 lesions were demonstrated with technetium Tc 99m pertechnetate and (15 out of 20) with Tc 99m albumin. There were 3 false positive with Tc 99m albumin. Of the 42 studies interpreted as normal with both agents, 27 were equal in quality. In 15 the Tc 99m albumin study was more difficult to interpret because of the confusing concentrations of the tracer in certain vascular structures. Technetium Tc 99m pertechnetate remains the agent of choice for routine screening work.
KW  - Technetium Tc 99m albumin--comparison, technetium Tc 99m pertechnetate-;
KW  - Technetium Tc 99m pertechnetate--comparison, technetium Tc 99m albumin-;
KW  - Radiopharmaceuticals--technetium Tc 99m pertechnetate, comparison, technetium Tc 99m albumin--brain scanning, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - NEWS
AU  - Ramos, Juan
T1  - Editorial notes.
JO  - Social Casework
JF  - Social Casework
Y1  - 1971/05//
VL  - 52
IS  - 5
M3  - Editorial
SP  - 323
EP  - 324
SN  - 00377678
AB  - Part of a special issue on the Chicano movement. The intention of this issue of 'Social Casework' is to inform social workers about the problems of Chicanos, so they can more effectively serve this long-suppressed, neglected minority.
KW  - ETHNOLOGY -- United States
KW  - MEXICAN Americans
KW  - SOCIAL services
KW  - PUBLIC welfare
KW  - SOCIAL workers
KW  - UNITED States
N1  - Accession Number: 15430352; Ramos, Juan 1; Affiliations: 1 : Office of Program Liaison National Institute of Mental Health Chevy Chase, Maryland.;  Source Info: May71, Vol. 52 Issue 5, p323; Historical Period: 1971; Subject Term: ETHNOLOGY -- United States; Subject Term: MEXICAN Americans; Subject Term: SOCIAL services; Subject Term: PUBLIC welfare; Subject Term: SOCIAL workers; Subject: UNITED States; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Blumenfeld, Dennis E.
AU  - Weiss, George H.
T1  - Merging from an Acceleration Lane.
JO  - Transportation Science
JF  - Transportation Science
Y1  - 1971/05//
VL  - 5
IS  - 2
M3  - Article
SP  - 161
PB  - INFORMS: Institute for Operations Research
SN  - 00411655
AB  - There have been many studies of the merging delay problem; that is, the problem of calculating delay to a vehicle at a stop sign, waiting to merge with a single stream of traffic. In this article, a model is presented for merging from an acceleration lane of finite length. An expression for the expected delay is given. A driver in an acceleration lane will try to match his speed to the traffic on the major road, in order to create gaps that are as large as possible. Failing to merge while moving in the acceleration lane, the motorist will decelerate to come to a stop at the end of the lane. The calculations suggest that the expected delay does not depend strongly on the length of the acceleration lane and that most of the merging occurs near the beginning of the lane.
KW  - LANE lines (Roads)
KW  - ACCELERATION (Mechanics)
KW  - TRAFFIC signs & signals
KW  - TRANSPORTATION
KW  - TRAFFIC patterns
N1  - Accession Number: 4470646; Blumenfeld, Dennis E. 1 Weiss, George H. 2; Affiliation:  1: Traffic Studies Group, University College, London, England.  2: National Institutes of Health, Bethesda, Maryland.; Source Info: May71, Vol. 5 Issue 2, p161; Subject Term: LANE lines (Roads); Subject Term: ACCELERATION (Mechanics); Subject Term: TRAFFIC signs & signals; Subject Term: TRANSPORTATION; Subject Term: TRAFFIC patterns; NAICS/Industry Codes: 561990 All Other Support Services; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; NAICS/Industry Codes: 237310 Highway, Street, and Bridge Construction; NAICS/Industry Codes: 488990 Other support activities for transportation; NAICS/Industry Codes: 488999 All Other Support Activities for Transportation; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Meriwether, W. D.;
AU  - Jangi, R. J.;
AU  - Serpick, A. A.;
T1  - Deafness following standard intravenous dose of ethacrynic acid
CT  - Deafness following standard intravenous dose of ethacrynic acid
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1971/05/03/
VL  - 216
IS  - May 3
SP  - 795
EP  - 798
AD  - Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1  - Accession Number: 8-2667; Language: English; Chemical Name: Ethacrynic acid--58-54-8; Therapeutic Class: (40:28); AHFS Class: Diuretics ethacrynic acid; References: 12; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2  - Two nonuremic patients experienced neurosensory hearing loss after the intravenous administration of standard doses of ethacrynic acid. Both were receiving nontoxic doses of aminoglycoside antibiotics concurrently. Total deafness occurred within 15 minutes of the administration of ethacrynic acid and was not accompanied by vertigo, nausea, or vomiting. The impairment of hearing was clearly transient in one patient. In the other patient, results of histologic examination of the inner ear at the time of autopsy were normal.
KW  - Ethacrynic acid--deafness-;
KW  - Diuretics--ethacrynic acid--deafness, following standard I.V. dose, cases;
KW  - Drugs, adverse reactions--ethacrynic acid--deafness, following standard I.V. dose, cases;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schimpff, S.;
AU  - Satterlee, W.;
AU  - Young, V. M.;
AU  - Serpick, A.;
T1  - Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia
CT  - Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/05/13/
VL  - 284
IS  - May 13
SP  - 1061
EP  - 1065
SN  - 00284793
AD  - National Cancer Institute-Baltimore Cancer Research Center, 3100 Wyman Park Drive, Baltimore, Maryland 21211
N1  - Accession Number: 9-1891; Language: English; Chemical Name: Carbenicillin--4697-36-3 Gentamicin--1403-66-3; Therapeutic Class: (8:12); AHFS Class: Antibiotics carbenicillin (8:12); AHFS Class: Antibiotics gentamicin; References: 16; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Seventy-five acutely ill, febrile patients with cancer and granulocytopenia were treated empirically with a combination of carbenicillin and gentamicin for presumed bacterial infection. Cultures taken before the initiation of antibiotics subsequently documented the presence of infection in 48 of these patients, of whom 21 were shown to have \IT/Pseudomonas aeruginosa \OK/infections. Fourteen of these patients with pseudomonas infections had complete improvement, 3 improved temporarily but later died of infection, 2 had no improvement, and 2 could not be evaluated. This antibiotic combination was less promising for the infections caused by other gram-negative bacteria, especially klebsiella. Superinfection occurred in 8 patients. Combination carbenicillin and gentamicin is of value as initial antibiotic therapy for suspected \IT/Ps. aeruginosa \OK/infection in granulocytopenic patients with cancer but only after careful examination and extensive culturing.
KW  - Carbenicillin--and gentamicin-;
KW  - Gentamicin--and carbenicillin-;
KW  - Combined therapy--carbenicillin and gentamicin--in presumed bacterial sepsis, in patients;
KW  - Rational therapy--carbenicillin and gentamicin--in presumed bacterial sepsis, in patients;
KW  - Antibiotics--carbenicillin--and gentamicin, combined therapy, in presumed bacterial sepsis, in patients;
KW  - Antibiotics--gentamicin--and carbenicillin, combined therapy, in presumed bacterial sepsis, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - BERNSTEIN, IRWIN D.
AU  - THOR, DANIEL E.
AU  - ZBAR, BERTON
AU  - RAPP, HERBERT J.
T1  - Tumor hnmunity: Tumor Suppression in vivo Initiated by Soluble Products of Specifically Stimulated Lymphocytes.
JO  - Science
JF  - Science
Y1  - 1971/05/14/
VL  - 172
IS  - 3984
M3  - Article
SP  - 729
EP  - 731
SN  - 00368075
AB  - Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intradermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268349; BERNSTEIN, IRWIN D. 1; THOR, DANIEL E. 1; ZBAR, BERTON 1; RAPP, HERBERT J. 1; Affiliations: 1: Biology Branch, National Cancer Institute and Laboratory of Virology and Rickettsiology, Division of Biologics Standards, Bethesda, Maryland 20014; Issue Info: 5/14/1971, Vol. 172 Issue 3984, p729; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - KLEIN, RONALD
AU  - HERMAN, SHELDON
T1  - Precautions with Alkyl Mercury.
JO  - Science
JF  - Science
Y1  - 1971/05/21/
VL  - 172
IS  - 3985
M3  - Article
SP  - 872
EP  - 872
SN  - 00368075
N1  - Accession Number: 85198691; KLEIN, RONALD 1; HERMAN, SHELDON 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 5/21/1971, Vol. 172 Issue 3985, p872; Number of Pages: 1/2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - BUREAUCRATIC MAN: A PORTRAIT AND AN INTERPRETATION.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1971/06//
VL  - 36
IS  - 3
M3  - Article
SP  - 461
EP  - 474
SN  - 00031224
AB  - There is a small but consistent tendency for men who work in bureaucratic organizations to be more intellectually flexible, more open to new experience, and more self-directed in their values than are men who work in nonburcaucratic organizations. This may in port result from bureaucracies' drawing on a more educated work force. in larger part, though, it appear: to be a consequence of occupational conditions attendant on bureaucratization-notably, far greater job protections, somewhat higher income, and substantively more complex work. [ABSTRACT FROM AUTHOR]
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KW  - BUREAUCRACY
KW  - ORGANIZATIONAL sociology
KW  - LABOR supply
KW  - INCOME
KW  - INTERORGANIZATIONAL relations
KW  - INTELLECTUALS
KW  - Administrative Processes and Organizational Variables
KW  - Organizing
N1  - Accession Number: 14846358; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun71, Vol. 36 Issue 3, p461; Thesaurus Term: BUREAUCRACY; Thesaurus Term: ORGANIZATIONAL sociology; Thesaurus Term: LABOR supply; Thesaurus Term: INCOME; Thesaurus Term: INTERORGANIZATIONAL relations; Subject Term: INTELLECTUALS; Author-Supplied Keyword: Administrative Processes and Organizational Variables; Author-Supplied Keyword: Organizing; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Weiss, I. W.;
AU  - Fisher, L.;
AU  - Phang, J. M.;
T1  - Diphosphonate therapy in a patient with myositis ossificans progressiva
CT  - Diphosphonate therapy in a patient with myositis ossificans progressiva
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/06/01/
VL  - 74
IS  - Jun
SP  - 933
EP  - 936
SN  - 00034819
AD  - Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 8-3766; Language: English; Chemical Name: Calcium--7440-70-2; References: 12; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - A young man with severe debility from myositis ossificans progressiva was treated with sodium etidronate, a diphosphonate known to reduce the rates of hydroxyapatite formation and dissolution. He showed progressive improvement while receiving therapy. Radiocalcium kinetics and metabolic balance studies documented the reduction of bone mineral accretion and resorption rates. A lack of change in body calcium balance during diphosphonate administration suggests that sodium etidronate can initiate the desired clinical effect without demineralizing skeletal bone.
KW  - Etidronate--sodium-;
KW  - Calcium--metabolism-;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Newsome, D. A.;
AU  - Wong, V. G.;
AU  - Cameron, T. P.;
AU  - Anderson, R. R.;
T1  - Steroid-induced mydriasis and ptosis
CT  - Steroid-induced mydriasis and ptosis
JO  - Invest. Ophthalmol.
JF  - Invest. Ophthalmol.
Y1  - 1971/06/01/
VL  - 10
IS  - Jun
SP  - 424
EP  - 429
AD  - Clinical Branch, National Eye Institute, National Institutes of Health, U. S. Dept. of Health, Education & Welfare, Bethesda, Maryland
N1  - Accession Number: 8-4176; Language: English; Trade Name: Decadron; Generic Name: Dexamethasone; Chemical Name: Dexamethasone--50-02-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- dexamethasone (52:00); AHFS Class: Solutions, ophthalmic dexamethasone; References: 9; Journal Coden: INOPAO; Section Heading: Toxicity; Pharmacology; Abstract Author: James W. Dungee
N2  - A study of the effect of 0.1% dexamethasone phosphate and various vehicle mixtures on the pupil size, width of palpebral fissure and intraocular pressure in a group of rhesus monkeys was made. The agents investigated in the study were dexamethasone (Decadron) in a vehicle mixture, the vehicle alone, some individual constituents of the vehicle, and dexamethasone in saline. Sterile sodium chloride 0.85% was used as a control. The solutions were administered both by subconjunctival injection and anterior chamber perfusion. The results seem to indicate that the ptosis and sometimes mydriasis is due to an effect of the vehicle and not the steroid.
KW  - Dexamethasone--phosphate-;
KW  - Steroids, cortico---dexamethasone--phosphate, side effects of mydriasis and ptosis due to vehicle, in monkeys;
KW  - Toxicity studies--dexamethasone--phosphate, side effects of mydriasis and ptosis due to vehicle, in monkeys;
KW  - Vehicles--dexamethasone--phosphate, responsible for mydriasis and ptosis, in monkeys;
KW  - Solutions, ophthalmic--dexamethasone--phosphate, vehicle responsible for mydriasis and ptosis, in monkeys;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Murphy, D. L.;
AU  - Bunney, W. E.;
T1  - Total body potassium change during lithium administration
CT  - Total body potassium change during lithium administration
JO  - J. Nerv. Ment. Dis.
JF  - J. Nerv. Ment. Dis.
Y1  - 1971/06/01/
VL  - 152
IS  - Jun
SP  - 381
EP  - 389
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institutes of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20014
N1  - Accession Number: 9-0955; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 34; Journal Coden: JNMDAN; Human Indicator: Yes; Section Heading: Toxicity
N2  - Total body potassium decreased after 2 weeks of lithium administration in 12 of 13 depressed patients but increased in 6 or 7 manic patients treated under identical conditions. Lithium carbonate was administered on a nonrandomized double-blind basis in a dosage of 1.2-1.8 g./day calculated according to age and weight to give a blood level of about 1.2 meq./day. These opposite changes were statistically significant for each group of patients. In a smaller group of depressed patients followed for longer periods during lithium treatment, the potassium levels returned to pre-lithium values. The dependence of the direction of potassium change on the clinical state of the patient may be related to some previously described differences between manic and depressed patients and also to differences in the therapeutic response to lithium between the 2 groups. A whole body counting method for \SU/40\BS/K was used to measure the cumulative changes in total body potassium content during the initial 2 weeks of lithium administration.
KW  - Lithium carbonate--toxicity-;
KW  - Toxicity--lithium carbonate--effects, total body potassium, in patients;
KW  - Psychotherapeutic agents--lithium carbonate--effects, total body potassium, in patients;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - PITHA, JOSEF
AU  - PITHA, PAULA M.
T1  - Antiviral Resistance by the Polyinosiiic Acid-Poly(l-vinylcytosine) Complex.
JO  - Science
JF  - Science
Y1  - 1971/06/11/
VL  - 172
IS  - 3988
M3  - Article
SP  - 1146
EP  - 1148
SN  - 00368075
AB  - The antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(I)-poly(C)], which is a potent interferon inducer, have been studied. Structural changes that modify the polymer backbone substantially, such as loops or 2' → 5' phosphodiester bonds, lead to decreased antiviral activity. Unexpectedly, however, the complex oj polyinosinic acid and poly(J-vinylcytosine), which is only a much more distantly related analog of poly(l) poly;(C), shows high activity. It is postulated that the high activity is related to the reduction of the charge! mass ratio and to the existence of this complex in an aggregated state; these are two factors that generally enhance the uptake of compounds by cells. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268477; PITHA, JOSEF 1; PITHA, PAULA M. 2; Affiliations: 1: Gerontology Research Center, National Institute of Child Health and Human Development, Baltimore City Hospitals, Baltimore, Maryland 21224; 2: Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland; Issue Info: 6/11/1971, Vol. 172 Issue 3988, p1146; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - GLENNER, G. G.
AU  - TERRY, W.
AU  - HARADA, M.
AU  - ISERSKY, C.
AU  - PAGE, D.
T1  - Amyloid Fibril Proteins: Proof of Homology with Immunoglobulin Light Chains by Sequence Analyses.
JO  - Science
JF  - Science
Y1  - 1971/06/11/
VL  - 172
IS  - 3988
M3  - Article
SP  - 1150
EP  - 1151
SN  - 00368075
AB  - The sequences of the 35 and 36 amino-terminal amino acids of two purified amyloid fibril proteins have been determined. Results indicate that these two proteins are derived from homogeneous immunoglobulin light chains of variable region subgroup VKI. The relation between amyloidosis and immunoglobulins is thus more firmly established . [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268479; GLENNER, G. G. 1; TERRY, W. 1; HARADA, M. 1; ISERSKY, C. 1; PAGE, D. 1; Affiliations: 1: National Institutes of Health, Bethesda. Maryland 20014; Issue Info: 6/11/1971, Vol. 172 Issue 3988, p1150; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - LEVITAN, HERBERT
T1  - Salicylate: Effect on Membrane Permeability of Molluscan Neurons.
JO  - Science
JF  - Science
Y1  - 1971/06/18/
VL  - 172
IS  - 3989
M3  - Article
SP  - 1245
EP  - 1247
SN  - 00368075
AB  - Identified cells in the buccal ganiglion of the marine mnollusk Navanax inermis were exposed to salicylate (1 to 30 millimoles per liter) for short periods. Salicylate increased the permneability to potassiumii and decreased the permeability to chloride in a reversible, dose-dependent manner, producing a concomitant increase in membrane potential and a decrease in mnemnbrane resistance. These events would reduce the output from, (15 well as the effectiveness of synaptic input to, a particular neuron. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87499025; BARKER, JEFFERY L. 1; LEVITAN, HERBERT 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/18/1971, Vol. 172 Issue 3989, p1245; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GELB, LAWRENCE D.
AU  - AARONSON, STUART A.
AU  - MARTIN, MALCOLM A.
T1  - Heterogeneity of Murine Leukemia Virus in vitro DNA; Detection of Viral DNA in Mammalian Cells.
JO  - Science
JF  - Science
Y1  - 1971/06/25/
VL  - 172
IS  - 3990
M3  - Article
SP  - 1353
EP  - 1355
SN  - 00368075
AB  - Kinetic analysis of the reassociation of DNA synthesized in vitro by a murine leukemia virus DNA polymerase revealed two classes of doublestranded product representative of 25 and 100 percent of viral genetic information. The DNA product representing the smaller portion of the viral genome comprised 85 percent of the double-stranded DNA generated in vitro and was extensively duplicated in the genomes of both normal cells amid cells containing RNA ticmor virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85289235; GELB, LAWRENCE D. 1; AARONSON, STUART A. 2; MARTIN, MALCOLM A. 1; Affiliations: 1: Laboratory of Biology of Virutses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/25/1971, Vol. 172 Issue 3990, p1353; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - EISENMAN, JOSEPH S.
AU  - EDINGER, HENRY M.
AU  - BARKER, JEFFERY L.
AU  - CARPENTER, DAVID 0.
T1  - Neuronal Thermosensitivity.
JO  - Science
JF  - Science
Y1  - 1971/06/25/
VL  - 172
IS  - 3990
M3  - Article
SP  - 1360
EP  - 1362
SN  - 00368075
N1  - Accession Number: 85289238; EISENMAN, JOSEPH S. 1; EDINGER, HENRY M. 2; BARKER, JEFFERY L. 3,4; CARPENTER, DAVID 0. 3; Affiliations: 1: Mount Sinai School of Medicine, New York 10029; 2: Rockefeller University, New York 10021; 3: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 4: Electroencephalography Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014; Issue Info: 6/25/1971, Vol. 172 Issue 3990, p1360; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schall, G. L.;
AU  - Anderson, L. G.;
AU  - Wolf, R. O.;
AU  - Herdt, J. R.;
AU  - Tarpley, T. M.;
AU  - \ET/;
T1  - Xerostomia in Sjorgren's syndrome. Evaluation by sequential salivary scintigraphy
CT  - Xerostomia in Sjorgren's syndrome. Evaluation by sequential salivary scintigraphy
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1971/06/28/
VL  - 216
IS  - Jun 28
SP  - 2109
EP  - 2116
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0548; Language: English; Therapeutic Class: (36:00); AHFS Class: Diagnostic agents sodium pertechnetate (78:00); AHFS Class: Radiopharmaceuticals sodium pertechnetate; References: 21; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Sequential salivary scintigraphy, or the visual recording with a gamma scintillation camera of the uptake, concentration, and excretion of \SU/99m\BS/Tc pertechnetate by the major salivary glands after the administration of sodium pertechnetate Tc 99m, was performed on 20 female patients with Sjogren's syndrome. The results were compared with those of other procedures currently used to evaluate xerostomia. The scintigraphic findings closely paralleled the results of the salivary flow-rate determinations and contrast sialography and the patients' clinical symptoms, but did not correlate with the finding of lymphocytic infiltration in lip biopsy specimens or the detection of the anti-salivary-duct antibody. The scintigraphic examination proved to be extremely sensitive in depicting small asymmetric differences in parotid gland activity and in monitoring the improvement in salivary gland function with immunosuppressive therapy. Sequential salivary scintigraphy appears to be an easy, safe, and objective means of evaluating xerostomia in patients with Sjogen's syndrome.
KW  - Sodium pertechnetate--Tc 99m-;
KW  - Diagnostic agents--sodium pertechnetate--Tc 99m, in evaluating xerostomia in females with Sjogen's syndrome by sequential salivary scintigraphy;
KW  - Radiopharmaceuticals--sodium pertechnetate--Tc 99m, in evaluating xerostomia in females with Sjogen's syndrome by sequential salivary scintigraphy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Oren, M. E.
AU  - Herberman, R. B.
T1  - DELAYED CUTANEOUS HYPERSENSITIVITY REACTIONS TO MEMBRANE EXTRACTS OF HUMAN TUMOUR CELLS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1971/07//
VL  - 9
IS  - 1
M3  - Article
SP  - 45
EP  - 56
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Autochthonous tumour cell membrane extracts produced delayed hypersensitivity reactions in patients with a variety of neoplastic diseases. When tested at low protein concentrations (&les;0.33 mg/0.1 ml), autochthonous tumour extracts produced positive reactions in 50% of non-anergic cancer patients. The same dose of autochthonous leucocyte membranes produced a significantly lower incidence of positive reactions (10%) in normal volunteers. In contrast, the cancer patients were less reactive than the normal volunteers to a battery of standard skin test antigens. In patients with acute lymphocytic leukaemia, positive reactions were more often obtained during remission. The protein concentration of the extracts was found to be an important factor in these studies. Extracts with high protein concentrations elicited positive reactions in both the patients and in the normal volunteers. It remains to be determined whether the reactions to the high protein concentrations are due to non-specific inflammation or to a low level of autoimmunity in both patients and controls. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN diseases
KW  - CELL membranes
KW  - TUMORS
KW  - CANCER
KW  - CANCER patients
KW  - LYMPHOCYTIC leukemia
KW  - PROTEINS
N1  - Accession Number: 14555249; Oren, M. E. 1 Herberman, R. B. 1; Affiliation:  1: Immunology Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Jul71, Vol. 9 Issue 1, p45; Subject Term: SKIN diseases; Subject Term: CELL membranes; Subject Term: TUMORS; Subject Term: CANCER; Subject Term: CANCER patients; Subject Term: LYMPHOCYTIC leukemia; Subject Term: PROTEINS; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodell, B.;
AU  - Leventhal, B.;
AU  - Henderson, E.;
T1  - Cytosine arabinoside in acute granulocytic leukemia
CT  - Cytosine arabinoside in acute granulocytic leukemia
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1971/07/01/
VL  - 12
IS  - Jul-Aug
SP  - 599
EP  - 606
SN  - 00099236
AD  - Leukemia Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 9-4201; Language: English; Trade Name: Cytosine arabinoside--Ara-C; Generic Name: Cytarabine; Cytarabine; Chemical Name: Cytarabine--147-94-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cytarabine; References: 25; Journal Coden: CLPTAT; Section Heading: Drug Evaluations
N2  - Cytosine arabinoside (cytarabine; Ara-C) was administered to 49 patients with acute granulocytic leukemia between 1966 and 1969. Ara-C was given by 4 hour infusion at a dose of 70 to 150 mg./m.\SU/2\BS//day in repeated 4 day courses. Complete remissions were achieved in 42% of patients. Of patients receiving Ara-C as initial chemotherapy, 25% died during attempted induction and 25% attained complete remission; of patients who had received prior chemotherapy (irrespective of response), 67% achieved complete remission. Infection (73%) and hepatic dysfunction (44%) were common complications of therapy. Median duration of remission in 21 patients receiving weekly Ara-C at 75 mg./m.\SU/2\BS/ S.C. as maintenance chemotherapy was 5 months. Median survival in patients achieving remission with Ara-C was 17 months; patients failing induction with this drug lived a median of 6 months. Ara-C is an effective and well-tolerated chemotherapeutic agent in acute granulocytic leukemia.
KW  - Cytarabine--leukemia-;
KW  - Antineoplastic agents--cytarabine--leukemia, granulocytic, acute, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jasinski, D. R.;
AU  - Martin, W. R.;
AU  - Hoeldtke, R.;
T1  - Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man
CT  - Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1971/07/01/
VL  - 12
IS  - Jul-Aug
SP  - 613
EP  - 649
SN  - 00099236
AD  - The National Institute of Mental Health Addiction Research Center, and the United States Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1  - Accession Number: 9-4369; Language: English; Trade Name: CI-572--BAY-4503; Generic Name: Profadol; Propiram; Chemical Name: Profadol--428-37-5 Propiram--15686-91-6; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics GPA-1657 (28:08); AHFS Class: Analgesics and antipyretics profadol (28:08); AHFS Class: Analgesics and antipyretics propiram; References: 29; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Toxicity; Investigational Drugs
N2  - GPA-1657, profadol hydrochloride (CI-572), and propiram fumarate (BAY-4503) are proposed as analgesics of low abuse potential since none will suppress but each will precipitate abstinence in morphine-dependent monkeys. GPA-1657 is not an antagonist in man but a typical morphine-like compound and is judged to have significant abuse potential. Profadol and propiram act as antagonists in man and precipitate abstinence in subjects dependent on 240 mg. of morphine per day. As agonists, profadol and propiram resemble morphine-like rather than nalorphine-like drugs, since both produce morphine-like subjective effects and physical dependence and suppress abstinence in subjects dependent on 60 mg. per day of morphine. Both were judged to have abuse potential. Propiram was judged to have somewhat less abuse potential than profadol, since it produces less euphoria and less physical dependence. The morphine antagonist properties of profadol and propiram are thought to be caused by the fact that they are morphine agonists with less intrinsic activity than morphine.
KW  - GPA-1657--toxicity-;
KW  - Profadol--hydrochloride-;
KW  - Propiram--fumarate-;
KW  - Toxicity--GPA-1657--abuse potential, studies, compared to profadol and propiram, in patients;
KW  - Toxicity--profadol--hydrochloride, abuse potential, studies, compared to GPA-1657 and propiram, in patients;
KW  - Toxicity--propiram--fumarate, abuse potential, studies, compared to GPA-1657 and profadol, in patients;
KW  - Analgesics and antipyretics--GPA-1657--abuse potential, studies, compared to profadol and propiram, in patients;
KW  - Analgesics and antipyretics--profadol--hydrochloride, abuse potential, studies, compared to GPA-1657 and propiram, in patients;
KW  - Analgesics and antipyretics--propiram--fumarate, abuse potential, studies, compared to GPA-1657 and profadol, in patients;
KW  - Dependence--GPA-1657--potential, studies, compared to profadol and propiram, in patients;
KW  - Dependence--profadol--hydrochloride, potential, studies, compared to GPA-1657 and propiram, in patients;
KW  - Dependence--propiram--fumarate, potential, studies, compared to GPA-1657 and profadol, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Baker, A. R.
AU  - Borsos, T.
AU  - Clten, H.R.
T1  - Cytotoxic Action of Antiserum and Complement: Quantification with a Colony Inhibition Method.
JO  - Immunology
JF  - Immunology
Y1  - 1971/07//
VL  - 21
IS  - 1
M3  - Article
SP  - 33
EP  - 43
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Describes the application of the colony inhibition technique to the study of the mechanism of complement mediated injury to nucleated cells. Morphologic changes induced by complement mediated cell lysis; Kinetics of complement lysis of sensitized Chinese hamster lung (CHL) cells; Effect of dose and species of complement on cell lysis; Effect of temperature on sensitization of CHL cells; Antibody dose response curve. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE serums
KW  - COMPLEMENT (Immunology)
KW  - BLOOD proteins
KW  - CELLS
KW  - HAMSTERS
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGY
N1  - Accession Number: 13362442; Baker, A. R. 1 Borsos, T. 2 Clten, H.R. 2; Affiliation:  1: Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston, Mass, 02115, U.S.A.  2: Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Jul71, Vol. 21 Issue 1, p33; Subject Term: IMMUNE serums; Subject Term: COMPLEMENT (Immunology); Subject Term: BLOOD proteins; Subject Term: CELLS; Subject Term: HAMSTERS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gips, James
AU  - Pfefferbaum, Adolf
AU  - Buchsbaum, Monte
T1  - USE OF A SMALL PROCESS CONTROL COMPUTER IN A PSYCHOPHYSIOLOGICAL LABORATORY.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1971/07//
VL  - 8
IS  - 4
M3  - Article
SP  - 538
EP  - 542
SN  - 00485772
AB  - The use of a classic LINC computer in a psychophysiological laboratory is described. A monitor system provides a standard framework for running and analyzing the experiments of several investigators. The monitor system allows the LINC to be run remotely via two push buttons and a CRT display. The LINC is used to simultaneously collect data and generate stimuli. The system is flexible, economical, and can be run by persons with no previous computer experience. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSYCHOPHYSIOLOGY
KW  - RESEARCH
KW  - PROCESS control
KW  - PERSONAL computers
N1  - Accession Number: 11050404; Gips, James 1 Pfefferbaum, Adolf 2 Buchsbaum, Monte 1; Affiliation:  1: Unit on Psychophysiology, Laboratory of Psychology, National Institute of Mental Health, Bethesda  2: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda; Source Info: Jul1971, Vol. 8 Issue 4, p538; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: RESEARCH; Subject Term: PROCESS control; Subject Term: PERSONAL computers; NAICS/Industry Codes: 334111 Electronic Computer Manufacturing; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-41058-010
AN  - 2013-41058-010
AU  - Waldrop, Mary F.
AU  - Goering, Jacob D.
T1  - Hyperactivity and minor physical anomalies in elementary school children.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1971/07//
VL  - 41
IS  - 4
SP  - 602
EP  - 607
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Waldrop, Mary F., Section on Child Behavior, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-41058-010. PMID: 4997640 Partial author list: First Author & Affiliation: Waldrop, Mary F.; Section on Child Behavior, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1970, San Francisco, CA, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Elementary Schools; Hyperkinesis; Physical Disfigurement. Minor Descriptor: Teachers. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 1971. 
AB  - Elementary school boys, whom their teachers had selected as being among the three most hyperactive in their classes, were found to have significantly more minor physical anomalies than boys selected as not being hyperactive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hyperactivity
KW  - physical anomalies
KW  - elementary school children
KW  - teachers
KW  - 1971
KW  - Elementary Schools
KW  - Hyperkinesis
KW  - Physical Disfigurement
KW  - Teachers
KW  - 1971
DO  - 10.1111/j.1939-0025.1971.tb03219.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - LEMBERGER, LOUIS
AU  - TAMARKIN, NORMAN R.
AU  - AXELROD, JULIUS
AU  - KOPIN, IRWIN J.
T1  - Delta-9-Tetrahydrocannabinol: Metabolism and Disposition in Long-Term Marihuana Smokers.
JO  - Science
JF  - Science
Y1  - 1971/07/02/
VL  - 173
IS  - 3991
M3  - Article
SP  - 72
EP  - 74
SN  - 00368075
AB  - Radioactively labeled delta-9-tetrahydrocannabinol (δ9THC) administered intravenously to chronic marihuana smokers disappeared from the blood plasma with a half-life of 28 hours as compared to 57 hours for nonusers of marihuana. Apparent volumes of distribution did not significantly difler between the two groups. Within 10 minutes after administration of δ9THC, 11-hydroxy- δ9THC is present in the plasma of nonusers and chronic users. This metabolite was also present in urine and feces of nonusers and long-term marihuana smokers. In addition, polar metabolites were excreted in urine and feces of both groups for more than 1 week. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159761; LEMBERGER, LOUIS 1; TAMARKIN, NORMAN R. 2; AXELROD, JULIUS 3; KOPIN, IRWIN J. 3; Affiliations: 1: Lahoratory of Clinical Science, National lmtitute of Mental Health, Bethesda, Maryland 20014. and Pharmacology-Toxicology Program. National lmtitute of General A1edical Sciences, Bethesda; 2: Division of Drug Treatment and Research, Veterans Administration Hospital Washington, D.C. 20422; 3: Lahoratory of Clinical Science, National Institute of Mental Health; Issue Info: 7/ 2/1971, Vol. 173 Issue 3991, p72; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DALE, DAVID C.
AU  - BROWN, CLARENCE H.
AU  - CARBONE, PAUL
AU  - WOLFF, SHELDON M.
T1  - Cyclic Urinary Leukopoietic Activity in Gray Collie Dogs.
JO  - Science
JF  - Science
Y1  - 1971/07/09/
VL  - 173
IS  - 3992
M3  - Article
SP  - 152
EP  - 153
SN  - 00368075
AB  - The urinary activities for bone marrow colony formation were measured on consecutive 24-hour urine samples from two gray collie dogs with cyclic neutropenia and from two normal collies. The activity varied cyclically in the gray collies with a peak activity developing during the neutropenic phase, which antecedes the return of blood neutrophils. The activity fell to undetectable levels after the blood neutrophil counts returned to the normal range. The urine of normal dogs showed no activity. Since the dogs with cyclic neutropenia have been shown to have periodic hematopoiesis, these data suggest a regulatory hormonal role for the substance measured by this assay. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159790; DALE, DAVID C. 1; BROWN, CLARENCE H. 2; CARBONE, PAUL 2; WOLFF, SHELDON M. 3; Affiliations: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland-20014; 2: Medical Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; Issue Info: 7/ 9/1971, Vol. 173 Issue 3992, p152; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MILHORAT, THOMAS H.
AU  - HAMMOCK, MARY K.
AU  - FENSTERMACHER, JOSEPH D.
AU  - RALL, DAVID P.
AU  - LEVIN, VICTOR A.
T1  - Cerebrospinal Fluid Production by the Choroid Plexus and Brain.
JO  - Science
JF  - Science
Y1  - 1971/07/23/
VL  - 173
IS  - 3994
M3  - Article
SP  - 330
EP  - 332
SN  - 00368075
AB  - The production of cerebrospinal fluid and the transport of 24Na from the blood to the cerebrospinal fluid were studied simultaneously in normal and choroid plexectomized rhesus monkeys. Choroid plexectomy reduced the production of cerebrospinal fluid by an average of 33 to 40 percent and the rate of appearance of 24Na in the cerebrospinal fluid and its final concentration were proportionately reduced. In both normal and plexectomized animals, 24Na levels were found to be markedly greater in the gray matter surrounding the ventricles and in the gray matter bordering the subarachnoid space. That sodium exchanges in these two general areas of the brain may be linked to the formation of the cerebrospinal fluid is discussed here. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159831; MILHORAT, THOMAS H. 1,2; HAMMOCK, MARY K. 3,4; FENSTERMACHER, JOSEPH D. 5; RALL, DAVID P. 5; LEVIN, VICTOR A. 6; Affiliations: 1: Office, Scientific Director, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland; 2: Department of Neurosurgery, Children's Hospital, Washington, D.C.; 3: Office, Scientific Director, National Institute of Neurological Diseases and Stroke; 4: Department of Neurosurgery, George Washington University, Washington, D.C.; 5: Office of Associate Scientific Director of Experimental Therapeutics, National Cancer Institute, Bethesda, Maryland; 6: Department of Neurology, Massachusetts Genieral Hospital, Boston; Issue Info: 7/23/1971, Vol. 173 Issue 3994, p330; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Herman, S.;
AU  - Klein, R.;
T1  - Alkyl mercury: unsafe at any speed
CT  - Alkyl mercury: unsafe at any speed
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/07/29/
VL  - 285
IS  - Jul 29
SP  - 297
SN  - 00284793
AD  - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
N1  - Accession Number: 8-4306; Language: English; Chemical Name: Mercury--7439-97-6; References: 9; Publication Type: Correspondence; Journal Coden: NEJMAG; Section Heading: Environmental Toxicity; Abstract Author: Joan Lentine
N2  - A growing body of evidence suggests that alkyl mercury intoxication may have much broader and more subtle forms of expression than previously recognized. Present knowledge of the toxicology of alkyl mercurialism is derived from studies of acutely intoxicated persons, usually in epidemic situations. Little is known about the effects of sublethal doses on the body. A hazardous effect of mercury is that it may potentiate the toxic effects of other environmental substances. This is suggested by decreased activity of hepatic microsomal detoxification systems in vivo and in vitro, of rats exposed to relatively low levels of alkyl mercury.
KW  - Mercury--alkyl-;
KW  - Toxicity, environmental--mercury--alkyl, effects in humans;
KW  - Drug interactions--mercury--potentiation, possible, of other environmental substances, in rats;
KW  - Dosage--mercury--sublethal, effects in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Mann, George V.
T1  - OBESITY, THE NUTRITIONAL SPOOK.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1971/08//
VL  - 61
IS  - 8
M3  - Article
SP  - 1491
EP  - 1498
PB  - American Public Health Association
SN  - 00900036
AB  - A down-to-earth, refreshing approach to the problems of obesity and its handling is presented. Emphasis is placed on exercise in controlling obesity rather than on drugs, and the point is made that campaigns against obesity may be based on ill-understood data. More reason and less emotion are prescribed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Health
KW  - Nutrition
KW  - Diseases
KW  - Nutrition disorders
KW  - Exercise
KW  - Obesity
KW  - Eating disorders
KW  - Appetite disorders
KW  - Body weight
N1  - Accession Number: 24845730; Mann, George V. 1,2; Affiliations: 1: Career Investigator, National Heart and Lung Institute, National Institutes of Health; 2: Associate Professor, Department of Biochemistry and Medicine, Vanderbilt University School of Medicine, Tennessee 37203; Issue Info: Aug1971, Vol. 61 Issue 8, p1491; Thesaurus Term: Health; Thesaurus Term: Nutrition; Thesaurus Term: Diseases; Subject Term: Nutrition disorders; Subject Term: Exercise; Subject Term: Obesity; Subject Term: Eating disorders; Subject Term: Appetite disorders; Subject Term: Body weight; Number of Pages: 8p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Steinberg, A. D.;
AU  - Kaltreider, B. H.;
AU  - Staples, P. J.;
AU  - Goetzl, E. J.;
AU  - Talal, N.;
AU  - \ET/;
T1  - Cyclophosphamide in lupus nephritis: a controlled trial
CT  - Cyclophosphamide in lupus nephritis: a controlled trial
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/08/01/
VL  - 75
IS  - Aug
SP  - 165
EP  - 171
SN  - 00034819
AD  - Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland) (reprints: J. L. Decker, Building 10, Room 9N218, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0352; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; References: 16; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Thirteen women with lupus nephritis were hospitalized for a 10-week double-blind therapeutic trial comparing oral cyclophosphamide with placebo. Concurrent corticosteroid therapy (up to 30 mg./day of prednisone) was permitted. Patients receiving cyclophosphamide had greater improvement than did placebo-treated patients in 5 indexes: anti-DNA antibodies, serum complement, urine sediment, proteinuria, and extrarenal disease. There was no difference in creatinine clearance. There was a strong positive correlation between cyclophosphamide dosage and number of indexes improved. Toxic side effects of cyclophosphamide were noted.
KW  - Cyclophosphamide--nephritis-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lee, H. G.;
AU  - Cheever, A. W.;
AU  - Fairweather, W. R.;
T1  - Influence of parasite strain on chemotherapy of murine infections with Schistosoma mansoni
CT  - Influence of parasite strain on chemotherapy of murine infections with Schistosoma mansoni
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1971/08/01/
VL  - 45
IS  - Aug
SP  - 147
EP  - 155
AD  - Laboratory of Parasitic Diseases, National Institute of Allergy & Infections Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-0371; Language: English; Language of Summary: fr; Chemical Name: Hycanthone--3105-97-3; References: 18; Journal Coden: BWHOA6; Section Heading: Preliminary Drug Testing
N2  - Groups of mice infected with each of several geographic strains of Schistosoma mansoni were treated with 1 of 4 selected drugs and parasiticidal effects were compared. Responses to treatment were generally similar among strains except in 2 trials involving a Puerto Rican strain that was unusually sensitive to hycanthone and relatively resistant to stibophen. Selective killing of male worms occurred consistently with lucanthone and hycanthone treatment. The use of portal perfusion rather than dissection to recover surviving worms appears to have been instrumental in allowing the relatively resistant female worms to be found, namely in the liver. The results indicate that strain differences in susceptibility to drugs do occur in \IT/S. mansoni\OK/, and apparent refractoriness or unusual sensitivity encountered in the field should be evaluated in the laboratory.
KW  - Stibophen--effects-;
KW  - Lucanthone--effects-;
KW  - Hycanthone--effects-;
KW  - Schistosomicides--hycanthone--effects, S. mansoni strains, in mice;
KW  - Schistosomicides--lucanthone--effects, S. mansoni strains, in mice;
KW  - Schistosomicides--stibophen--effects, S. mansoni strains, in mice;
KW  - Schistosoma mansoni--resistance--in strains from different geographical locations, effects of drugs, in mice;
KW  - Resistance--schistosomicides--Schistosoma mansoni strains, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Coe, J. B.
T1  - The Immune Response in the Hamster III. SELECTIVE INDUCTION OF CONCOMITANT ANTIBODY FORMATION AND UNRESPONSIVENESS IN THE 7Sγ1- AND 7Sγ2-GLOBULINS WITH SOLUBLE HEN EGG ALBUMIN.
JO  - Immunology
JF  - Immunology
Y1  - 1971/08//
VL  - 21
IS  - 2
M3  - Article
SP  - 175
EP  - 191
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Synthesis of antibody to hen egg albumin (HEA) was restricted to one of the 7S immunoglobulins (7Sγ1:globulin) when hamsters were inoculated with soluble HEA (HEA-saline). This selective induction occurred regardless of the amount of HEA-saline injected (0.001–5·0 mg) or the route of inoculation. In contrast, HEA in Freund's adjuvants induced synthesis of anti-HEA in both the 7Sγ1 - and 7Sγ2 -globulins, even when as little as 0.1 μg of HEA was used. Repeated inoculations of hamsters with HEA-saline increased or maintained 7Sγ1 antibody, but did not induce anti-HEA synthesis in the 7Sγ2 -globulins. The results of cell transfer experiments indicated that cells from HEA-saline treated hamsters were primed to synthesize 7Sγ1 anti-HEA and were specifically unresponsive for 7Sγ2 anti-HEA synthesis. Selective induction of antibody production and unresponsiveness, concomitantly, within different immunoglobulin classes suggests that different antibody induction mechanisms are utilized by these two immunoglobulin classes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALBUMINS
KW  - IMMUNOGLOBULINS
KW  - HAMSTERS
KW  - IMMUNE response
KW  - ANTIGENS
N1  - Accession Number: 13480522; Coe, J. B. 1; Affiliation:  1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Aug71, Vol. 21 Issue 2, p175; Subject Term: ALBUMINS; Subject Term: IMMUNOGLOBULINS; Subject Term: HAMSTERS; Subject Term: IMMUNE response; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Feldman, R J
AU  - Koniver, D A
T1  - Interactive searching of chemical files and structural diagram generation from wiswesser line notation
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1971/08//
VL  - 11
IS  - 3
M3  - Article
SP  - 154
EP  - 159
SN  - 00219576
AB  - An interactive search and retrieval system for wiswesser line notation (wln) has been implemented. The system employs bit screens, which are useful for filtering a file. The user can graphically specify a search request structure and immediately receive graphic information as the result of the search. Four fortran iv programs were developed to prepare bit screens for wln files, input the search request to generate the wln, iteratively search the wln bit screen file, and generate a two-dimensionald representation of the chemical structure directly from the wln.
N1  - Accession Number: ISTA0602858; Feldman, R J 1; Koniver, D A; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: August 1971, Vol. 11 Issue 3, p154; Note: Update Code: 0600; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bischoff, K. B.;
AU  - Dedrick, R. L.;
AU  - Zaharko, D. S.;
AU  - Longstreth, J. A.;
T1  - Methotrexate pharmacokinetics
CT  - Methotrexate pharmacokinetics
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1971/08/01/
VL  - 60
IS  - Aug
SP  - 1128
EP  - 1133
SN  - 00223549
AD  - Biomedical Engineering and Instrumentation Branch, Division of Research Services, and Laboratory of Chemical Pharmacology, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-0152; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 24; Journal Coden: JPMSAE; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: D. R. Tousignaut
N2  - A pharmacokinetic model is presented to predict the detailed distribution and excretion of methotrexate in several mammalian species over a wide range of doses. Tissue to plasma distribution coefficients include linear and strong saturable (presumed dihydrofolate reductase) effect. Required parameters are measured directly or estimated on the basis of physiological principles for mice, rats, dogs, and man. The model contains multicompartment descriptions of the biliary system and the intestine based on physiologic principles. Phenomena, such as local differences in intestinal absorption, could be incorporated if sufficient data were available. The model predicts tissue concentrations in the subhuman species and also predicts observed plasma concentrations and urinary and fecal excretion in man. Numerous graphs are included.
KW  - Methotrexate--pharmacokinetics-;
KW  - Pharmacokinetics--methotrexate--models, prediction of distribution and excretion, in animals and man;
KW  - Models--methotrexate--pharmacokinetics, prediction of distribution and excretion, in animals and man;
KW  - Antineoplastic agents--methotrexate--pharmacokinetics, models, prediction of distribution and excretion, in animals and man;
KW  - Drugs, body distribution--methotrexate--models, pharmacokinetics, in animals and man;
KW  - Excretion--methotrexate--models, pharmacokinetics, in animals and man;
KW  - Metabolism--methotrexate--models, pharmacokinetics, in animals and man;
KW  - Dosage--methotrexate--pharmacokinetics, models, predicts distribution and excretion, in animals and humans;
KW  - Tissue levels--methotrexate--models, pharmacokinetics, in animals and man;
KW  - Blood levels--methotrexate--models, pharmacokinetics, in animals and man;
KW  - Methodology--methotrexate--pharmacokinetics, model to predict distribution and excretion, in animals and humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Axelrod, J.;
T1  - Noradrenaline: fate and control of its biosynthesis
CT  - Noradrenaline: fate and control of its biosynthesis
JO  - Science
JF  - Science
Y1  - 1971/08/13/
VL  - 173
IS  - Aug 13
SP  - 598
EP  - 606
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0254; Language: English; Trade Name: Noradrenaline--Adrenaline; Generic Name: Norepinephrine; Epinephrine; Chemical Name: Norepinephrine--51-41-2 Epinephrine--51-43-4; Therapeutic Class: (12:12); AHFS Class: Sympathomimetic agents norepinephrine (12:12); AHFS Class: Sympathomimetic agents epinephrine; References: 103; Journal Coden: SCIEAS; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Anne Paula Thompson
N2  - This Nobel Prize lecture reviews research efforts in the field of noradrenaline (norepinephrine) and adrenaline (epinephrine) metabolism.
KW  - Norepinephrine--metabolism-;
KW  - Epinephrine--metabolism-;
KW  - Sympathomimetic agents--norepinephrine--metabolism, research, review;
KW  - Metabolism--norepinephrine--research, review;
KW  - Research--norepinephrine--metabolism, review;
KW  - Metabolism--epinephrine--research, review;
KW  - Sympathomimetic agents--epinephrine--metabolism, research, review;
KW  - Research--epinephrine--metabolism, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - DeVita, V. T., Jr.;
AU  - Serpick, A. A.;
AU  - Canellos, G. P.;
T1  - Treatment of advanced Hodgkin's disease with [1,3-bis](2-chloroethyl)-1-nitrosourea BCNU
CT  - Treatment of advanced Hodgkin's disease with [1,3-bis](2-chloroethyl)-1-nitrosourea BCNU
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/08/26/
VL  - 285
IS  - Aug 26
SP  - 475
EP  - 479
SN  - 00284793
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 9-0333; Language: English; Trade Name: BCNU; Generic Name: Carmustine; Chemical Name: Carmustine--154-93-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine; References: 12; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - BCNU (carmustine) was used to treat 45 patients with far advanced, previously treated Hodgkin's disease. Twenty-one patients achieved an appreciable remission. Nineteen patients had a partial remission for 16.5 weeks. Two patients had complete remissions for 72 to 208 weeks respectively. Leukopenia occurred in 24 patients, and thrombocytopenia in 32. BCNU has activity against Hodgkin's disease even when the disease is resistant to standard chemotherapeutic agents, and it appears not to be cross resistant with the alkylating agents.
KW  - Carmustine--Hodgkin's disease-;
KW  - Antineoplastic agents--carmustine--Hodgkin's disease, therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - PETCOFF, DARRELL G.
AU  - STRAIN, S. MICHAEL
AU  - BROWN, WILLIAM R.
AU  - RIBI, EDGAR
T1  - Maihna: Identification of Cannab. oids by Centrifugal Chromatography.
JO  - Science
JF  - Science
Y1  - 1971/08/27/
VL  - 173
IS  - 3999
M3  - Article
SP  - 824
EP  - 826
SN  - 00368075
AB  - Components in extracts of marihuana and hashish have been identified by a chromatographic technique in which centrifugal force is used to accelerate the migration of samples through columns of densely packed microparticulate gel. Rapid qualitative analysis and an estimate of the amounts of cannabinoids present was achieved. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002471; PETCOFF, DARRELL G. 1; STRAIN, S. MICHAEL 2; BROWN, WILLIAM R. 2; RIBI, EDGAR 2; Affiliations: 1: Ivan Sorvall, Inc. Instrument Research Laboratory, Hamilton, Montana 59840; 2: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840; Issue Info: 8/27/1971, Vol. 173 Issue 3999, p824; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gralnick, H. R.;
AU  - McGinniss, M.;
AU  - Elton, W.;
AU  - McCurdy, P.;
T1  - Hemolytic anemia associated with cephalothin
CT  - Hemolytic anemia associated with cephalothin
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1971/08/30/
VL  - 217
IS  - Aug 30
SP  - 1193
EP  - 1197
AD  - Hematology Service and Blood Bank, Clinical Center, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 9-0520; Language: English; Trade Name: Keflin; Generic Name: Cephalothin; Chemical Name: Cephalothin--153-61-7; Therapeutic Class: (8:12); AHFS Class: Antibiotics cephalothin; References: 12; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - Two patients developed Coombs' positive hemolytic anemia while receiving cephalothin sodium (Keflin) therapy. This complication of cephalothin therapy is rare, and must be differentiated from the positive Coombs' reaction seen in the majority of patients receiving cephalothin. In these 2 patients, Coombs' positive hemolytic anemia developed within 7 days of the initiation of cephalothin therapy. The dosage of cephalothin sodium was not excessive (2 and 6 g.), and neither patient was azotemic. In both patients a specific anticephalothin antibody was demonstrated. In one patient, this was demonstrable in the serum and eluate, and in the other patient, only in the eluate. In addition, one patient had an antipenicillin antibody. In both patients, the antibody directed against cephalothin appeared to be IgG. In any patient receiving cephalothin, unexplained hemolysis must include a search for anticephalothin and antipenicillin antibodies on the red blood cell before the drug can be implicated in any hemolytic episode.
KW  - Cephalothin--toxicity-;
KW  - Toxicity--cephalothin--development of positive hemolytic anemia, in patient;
KW  - Antibiotics--cephalothin--toxicity, development of positive hemolytic anemia, in patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Ozarin, Lucy D.
AU  - Feldman, Saul
T1  - IMPLICATIONS FOR HEALTH SERVICE DELIVERY: THE COMMUNITY MENTAL HEALTH CENTERS AMENDMENTS OF 1970.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1971/09//
VL  - 61
IS  - 9
M3  - Article
SP  - 1780
EP  - 1784
PB  - American Public Health Association
SN  - 00900036
AB  - A report is presented on some changes that have occurred as a result of the Community Mental Health Centers Act of 1970. Data are offered on the number of centers funded by the end of June, 1970, on their operations, and on some of the effects they have had. The need to develop these beginnings in relation to comprehensive care is stressed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Medical centers
KW  - Constitutional amendments
KW  - Medical care
KW  - Community mental health services
KW  - Health facilities
KW  - Constitutions
KW  - Community health services
N1  - Accession Number: 24845596; Ozarin, Lucy D. 1; Feldman, Saul 1; Affiliations: 1: Division of Mental Health Service Programs, National Institute of Mental Health, Rockville, MD; Issue Info: Sep1971, Vol. 61 Issue 9, p1780; Subject Term: Medical centers; Subject Term: Constitutional amendments; Subject Term: Medical care; Subject Term: Community mental health services; Subject Term: Health facilities; Subject Term: Constitutions; Subject Term: Community health services; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GIBSON, WILLIAM A.
T1  - Diagnostic Histochemistry.
JO  - BioScience
JF  - BioScience
Y1  - 1971/09//9/1/1971
VL  - 21
IS  - 17
M3  - Book Review
SP  - 926
EP  - 927
SN  - 00063568
AB  - The article reviews the book "Diagnostic Histochemistry," by F. T. Zugibe.
KW  - Histochemistry
KW  - Nonfiction
KW  - Zugibe, F. T.
KW  - Diagnostic Histochemistry (Book)
N1  - Accession Number: 32113469; GIBSON, WILLIAM A. 1; Affiliations: 1 : National Institute of Dental Research, National Institutes of Health, Bethesda, Md;  Source Info: 9/1/1971, Vol. 21 Issue 17, p926; Subject Term: Histochemistry; Subject Term: Nonfiction; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Sample, W. F.
AU  - Chretien, P. B.
T1  - THYMIDINE KINETICS IN HUMAN LYMPHOCYTE TRANSFORMATION: DETERMINATION OF OPTIMAL LABELLING CONDITIONS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1971/09//
VL  - 9
IS  - 3
M3  - Article
SP  - 419
EP  - 427
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The optimal conditions for assessing the rate of DNA synthesis by the incorporation of labelled thymidine in PHA-stimulated human lymphocytes were determined. Optimal labelling conditions could be sustained for only 3-4 hr. The exposure time was limited by both the failure to maintain saturating concentrations of exogenous thymidine and the deleterious affect of internal radiation. A linear incorporation of the label with time was not found to be a reliable criteria of optimal labelling conditions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYMIDINE
KW  - LYMPHOCYTES
KW  - PYRIMIDINE nucleotides
KW  - DNA
KW  - IMMUNOLOGY
KW  - LEUCOCYTES
N1  - Accession Number: 17364427; Sample, W. F. 1 Chretien, P. B. 1; Affiliation:  1: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Sep71, Vol. 9 Issue 3, p419; Subject Term: THYMIDINE; Subject Term: LYMPHOCYTES; Subject Term: PYRIMIDINE nucleotides; Subject Term: DNA; Subject Term: IMMUNOLOGY; Subject Term: LEUCOCYTES; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mantel, Nathan
AU  - Myers, Max
T1  - Problems of Convergence of Maximum Likelihood Iterative Procedures in Multiparameter Situations.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1971/09//
VL  - 66
IS  - 335
M3  - Article
SP  - 484
SN  - 01621459
AB  - In multiparameter situations there are important problems of convergence in the solution of maximum likelihood iterative equations. Convergence may be critically dependent on the initial parameter estimates employed. These problems are indicated specifically for a model of exponentially-distributed lifetimes where the reciprocal of the exponential parameter is linearly dependent on various regressor variables. A strategy is suggested based on alternative use of observed or expected values for the sample second derivative of the log likelihood. For the examples shown the initial parameter estimates correspond to no effect for the regressor variables, this being equivalent in some cases to making an unweighted fit to the data. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STOCHASTIC convergence
KW  - ESTIMATION theory
KW  - PARAMETER estimation
KW  - MATHEMATICAL statistics
KW  - ITERATIVE methods (Mathematics)
KW  - NUMERICAL analysis
KW  - EXPONENTIAL functions
N1  - Accession Number: 4607794; Mantel, Nathan 1; Myers, Max 1; Affiliations: 1: Mathematical Statiscian, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; Issue Info: Sep71, Vol. 66 Issue 335, p484; Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: ESTIMATION theory; Thesaurus Term: PARAMETER estimation; Thesaurus Term: MATHEMATICAL statistics; Subject Term: ITERATIVE methods (Mathematics); Subject Term: NUMERICAL analysis; Subject Term: EXPONENTIAL functions; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Sobel, Milton
AU  - Weiss, George H.
T1  - Play-the-Winner Rule and Inverse Sampling in Selecting the Better of Two Binomial Populations.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1971/09//
VL  - 66
IS  - 335
M3  - Article
SP  - 545
SN  - 01621459
AB  - In this article two sampling rules are analyzed for the problem of selecting the better of two binomial populations. The first is alternate sampling (vector-at-a. time) and the second is the "play-the-winner" rule introduced by Robbins [3], and discussed by Zelen [8]. The termination rule studied is inverse sampling. One result is that the probabilities of correct selection for these two methods of sampling are exactly equal. It is also found that the play-the-winner sampling is uniformly preferable to the vector-at-a-time sampling rule in the sense that for the same probability requirement the expected number of trials on the poorer population is always smaller. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORRELATION (Statistics)
KW  - SAMPLING (Statistics)
KW  - PROBABILITY theory
KW  - DOCUMENTATION
KW  - BINOMIAL distribution
KW  - BINOMIAL theorem
KW  - GUIDELINES
KW  - VECTOR algebra
N1  - Accession Number: 4607859; Sobel, Milton 1; Weiss, George H. 2; Affiliations: 1: Professor, Department of Statistics, University of Minnesota, Minneapolis, Minn. 55455.; 2: Chief, Physical Sciences Laboratory, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Sep71, Vol. 66 Issue 335, p545; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: PROBABILITY theory; Thesaurus Term: DOCUMENTATION; Subject Term: BINOMIAL distribution; Subject Term: BINOMIAL theorem; Subject Term: GUIDELINES; Subject Term: VECTOR algebra; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Halperin, Max
AU  - Gurian, Joan
T1  - A Note on Estimation in Straight Line Regression When Both Variables Are Subject to Error.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1971/09//
VL  - 66
IS  - 335
M3  - Article
SP  - 587
SN  - 01621459
AB  - This article focuses on the estimation in straight line regression when both variables are subject to error. It says that consistency, is a large sample property and it is of interest to inquire concerning small sample properties of b under reasonable assumptions. In a recent article D.H. Richardson and De-min Wu presented among other things the results of such an investigation. In particular they presented analytical and numerical results on the expected value and mean square error of b under the assumptions described above.
KW  - ESTIMATION theory
KW  - ANALYSIS of variance
KW  - REGRESSION analysis
KW  - EXPECTED returns
KW  - ERROR analysis (Mathematics)
KW  - MATHEMATICAL statistics
KW  - SAMPLING (Statistics)
KW  - VARIABLES (Mathematics)
KW  - NUMERICAL analysis
N1  - Accession Number: 4608131; Halperin, Max 1; Gurian, Joan 2; Affiliations: 1: Chief, Biometrics Research Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014.; 2: Mathematical Statistician, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Sep71, Vol. 66 Issue 335, p587; Thesaurus Term: ESTIMATION theory; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: REGRESSION analysis; Thesaurus Term: EXPECTED returns; Thesaurus Term: ERROR analysis (Mathematics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: SAMPLING (Statistics); Subject Term: VARIABLES (Mathematics); Subject Term: NUMERICAL analysis; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Buchsbaum, Monte
AU  - Pfefferbaum, Adolf
T1  - INDIVIDUAL DIFFERENCES IN STIMULUS INTENSITY RESPONSE.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1971/09//
VL  - 8
IS  - 5
M3  - Article
SP  - 600
EP  - 611
SN  - 00485772
AB  - Differences in the rate of increase of average evoked response (AER) amplitude with increasing intensity of light flash stimuli were studied in 80 male and 40 female college student volunteers. AERs to four intensities of light were recorded from the Ss and a measure of the rate of increase of AER amplitude with increasing stimulus intensity was obtained. Results from Ss tested twice, several weeks apart, showed that the slope of the amplitude intensity function was a stable individual characteristic. The observed amplitude intensity slope was greater in women than in men; vertex-ear leads showed lower slopes than vertex-occiput leads; subject handedness or hemisphere of lead derivation had little effect. Twenty extreme Ss, 10 individuals with the greatest slopes and 10 individuals with an actual decrease in AER amplitude with increasing stimulus intensity (negative slopes), were studied in greater detail. The amplitude-intensity slope was more affected by the absolute intensity of the light than the interstimulus interval or habituation effects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOKED response audiometry
KW  - VISUAL evoked response
KW  - BRIGHTNESS perception
KW  - ELECTROENCEPHALOGRAPHY
KW  - Average evoked response
KW  - EEG
KW  - Habituation
KW  - Light intensity
KW  - Perceptual style.
KW  - Visual evoked response
N1  - Accession Number: 11052617; Buchsbaum, Monte 1 Pfefferbaum, Adolf 2; Affiliation:  1: Unit on Psychophysiology, Laboratory of Psychology, National Institute of Mental Health, Bethesda.  2: Adult  Psychiatry Branch, National Institute of Mental Health, Bethesda.; Source Info: Sep1971, Vol. 8 Issue 5, p600; Subject Term: EVOKED response audiometry; Subject Term: VISUAL evoked response; Subject Term: BRIGHTNESS perception; Subject Term: ELECTROENCEPHALOGRAPHY; Author-Supplied Keyword: Average evoked response; Author-Supplied Keyword: EEG; Author-Supplied Keyword: Habituation; Author-Supplied Keyword: Light intensity; Author-Supplied Keyword: Perceptual style.; Author-Supplied Keyword: Visual evoked response; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1469-8986.ep11052617
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06143-025
AN  - 2006-06143-025
AU  - Huxley, Matthew
T1  - The Dream Dwellers.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1971/09//
VL  - 16
IS  - 9
SP  - 578
EP  - 579
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06143-025. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Huxley, Matthew; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Dream Analysis; Dream Content; Dreaming; Imagination; Opiates. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Hayter, Alethea. Opium and the Romantic Imagination=Berkeley, Calif.: University of California Press, 1970. Pp. 388. $7.50 cloth; $3.45 paper; 1970. Page Count: 2. Issue Publication Date: Sep, 1971. 
AB  - Reviews the book, Opium and the Romantic Imagination by Alethea Hayter (1970). This book is organized into three major sections, Setting, Theory; Practice; and a conclusion; Verdict. The author seeks to isolate those elements in the verbal and visual images and dreams of opium-addict writers which were not common to the dreams of other contemporary writers. To these nineteenth century Romantics, dreams were a revelation of a reality which could form and influence waking life, while the dream process was a parallel and model of the process of poetic creation. Urbane, informative, and admirably written, the book makes clear why Alethea Hayter is a Fellow of the Royal Academy of Literature. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Romantics
KW  - dream dwellers
KW  - dream process
KW  - opium
KW  - imagination
KW  - 1971
KW  - Dream Analysis
KW  - Dream Content
KW  - Dreaming
KW  - Imagination
KW  - Opiates
KW  - 1971
U2  - Hayter, Alethea. (1970); Opium and the Romantic Imagination; Berkeley, Calif.: University of California Press, 1970. Pp. 388. $7.50 cloth; $3.45 paper
DO  - 10.1037/0011424
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Grafius, Melba A.
AU  - Bond, Howard E.
AU  - Millar, David B.
T1  - Acetylcholinesterase Interaction with a Lipoprotein Matrix.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1971/09/02/
VL  - 22
IS  - 3
M3  - Article
SP  - 382
EP  - 390
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The nature of the components and some of the association forces in aggregated acetylcholinesterase, extracted from the electric organ of Electrophorus electricus, were investigated. The aggregated acetylcholinesterase (rapidly sedimenting, 70 S, and referred to as fast acetylcholinesterase) and the dissociated or "monomer" acetylcholinesterase (11.5 S and referred to as slow acetylcholinesterase) were isolated by zonal centrifugation. The fast acetylcholinesterase was further processed by gel filtration, resulting in a fast acetylcholinesterase of low specie activity and a slow acetylcholinesterase of high specie activity and a lowered sedimentation value (10.8 S). The fast acetylcholinesterase was exposed to the hydrolytic action of various enzymes (neuraminidase, hyaluronidase, alkaline phosphatase, and phospholipase A) and examined by sucrose gradient centrifugation techniques with no effect observed on the aggregation. However, phospholipases C and D and pancreatic lipase dissociated the fast acetylcholinesterase to the slow acetylcholinesterase (11.5 S). With phospholipase C, but not pancreatic lipase, the acetylcholinesterase was released from a matrix of ultraviolet absorbing, non-enzymatic material which remained in its aggregated form. With pancreatic lipase the matrix was also dissociated into a "monomer" species with a sedimentation value similar to that of the "monomer" acetylcholinesterase (resembling dissociation in high ionic strength). The hydrolytic action of the lipases did not alter the sedimentation value of the "monomer" nor its property of reversibly forming a gelatinous precipitate at pH 4.0. However, the slow acetylcholinesterase recovered from the gel column was not sensitive to the acid pH. The results indicate that the aggregated or fast acetylcholinesterase is a complex between "monomer" and a matrix of lipoproteins which, in itself, is an aggregation of molecular species similar in sedimentation value to the "monomer" acetylcholinesterase. A model is presented. Comparison between the matrix and the receptor protein is made. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIPOPROTEINS
KW  - ACETYLCHOLINESTERASE
KW  - CHOLINESTERASES
KW  - ELECTROPHORI
KW  - CARRIER proteins
KW  - MONOMERS
N1  - Accession Number: 13473769; Grafius, Melba A. 1 Bond, Howard E. 1 Millar, David B. 1; Affiliation:  1: Laboratory of Physical Biochemistry, Environmental Biosciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland and National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 1971, Vol. 22 Issue 3, p382; Subject Term: LIPOPROTEINS; Subject Term: ACETYLCHOLINESTERASE; Subject Term: CHOLINESTERASES; Subject Term: ELECTROPHORI; Subject Term: CARRIER proteins; Subject Term: MONOMERS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shapiro, Lucille
AU  - Agabian-Keshishian, Nina
AU  - Bendis, Ina
T1  - Bacterial Differentiation.
JO  - Science
JF  - Science
Y1  - 1971/09/03/
VL  - 173
IS  - 4000
M3  - Article
SP  - 884
EP  - 892
SN  - 00368075
N1  - Accession Number: 85362786; Shapiro, Lucille 1; Agabian-Keshishian, Nina 2; Bendis, Ina 2; Affiliations: 1: Assistant professor of molecular biology, department of molecular biology, division of biological sciences, Albert Einstein College of Medicine, New York; 2: National Institutes of Health predoctoral trainees, same department; Issue Info: 9/ 3/1971, Vol. 173 Issue 4000, p884; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSHILBOUM, RICHARD
AU  - AXELROD, JULIUS
T1  - Serum Dopamine-ß -Hydroxylase: Decrease after Chemical Sympathectomy.
JO  - Science
JF  - Science
Y1  - 1971/09/03/
VL  - 173
IS  - 4000
M3  - Article
SP  - 931
EP  - 934
SN  - 00368075
AB  - Dopamine-ß-hydroxylase is an enzyme that is localized to catecholamine- containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Treatment of rats with 6-hydroxydopamine, a drug which destroys sympathetic nerve terminals, leads to a decrease in serum dopamine- ß-hydroxylase activity. The decrease is not due to an effect on the adrenal medulla or to an increase in circulating inhibitor or inhibitors of enzyme. These data represent evidence that at least a portion of the circulating dopamine-ß- hydroxylase activity arises from sympathetic nerve terminals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85362812; WEINSHILBOUM, RICHARD 1; AXELROD, JULIUS 2; Affiliations: 1: Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institiute of Mental Health, Bethesda, Maryland 20014; Issue Info: 9/ 3/1971, Vol. 173 Issue 4000, p931; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - RAPOPORT, STANLEY I.
AU  - HORI, MASAHARU
AU  - KLATZO, IGOR
T1  - Reversible Osmotic Opening of the Blood-Brain Barrier.
JO  - Science
JF  - Science
Y1  - 1971/09/10/
VL  - 173
IS  - 4001
M3  - Article
SP  - 1026
EP  - 1028
SN  - 00368075
AB  - Reversible breakdown of the blood-brain barrier is produced by a class of electrolytes and nonelectrolytes which have little or no lipid solubility but which difler in chemical and ionic properties. These agents may osmotically shrink barrier cells, possibly the vascular endothelium, and reversibly open spaces between them. Lipid-soluble nonelectrolytes damage the barrier irreversibly. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87615549; RAPOPORT, STANLEY I. 1; HORI, MASAHARU 1; KLATZO, IGOR 2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disease and Stroke, Bethesda 20014; Issue Info: 9/10/1971, Vol. 173 Issue 4001, p1026; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MACLEOD, COLIN
T1  - Ihternational Cooperation in Science.
JO  - Science
JF  - Science
Y1  - 1971/09/17/
VL  - 173
IS  - 4002
M3  - Article
SP  - 1083
EP  - 1083
SN  - 00368075
N1  - Accession Number: 88002495; MACLEOD, COLIN 1; Affiliations: 1: Chairman, U.S. Delegation of the United States-Japan Cooperative Medical Science Committee, and HOWARD A. MINNERS, Secretariat, National Institutes of Health; Issue Info: 9/17/1971, Vol. 173 Issue 4002, following p1083; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PRIESTER, WILLIAM A.
T1  - Pet Cats and Pollutants.
JO  - Science
JF  - Science
Y1  - 1971/09/24/
VL  - 173
IS  - 4003
M3  - Article
SP  - 1191
EP  - 1191
SN  - 00368075
N1  - Accession Number: 87615488; PRIESTER, WILLIAM A. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/24/1971, Vol. 173 Issue 4003, p1191; Number of Pages: 1/9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Li, F. P.;
AU  - Nathan, D. G.;
T1  - Therapy-linked leukemia
CT  - Therapy-linked leukemia
JO  - British Medical Journal (England)
JF  - British Medical Journal (England)
Y1  - 1971/09/25/
VL  - 3
IS  - Sep 25
SP  - 765
SN  - 09598146
AD  - Children's Hospital Medical Center, Children's Cancer Research Foundation and National Cancer Institute Field Station, Boston, Massachusetts
N1  - Accession Number: 9-1602; Language: English; Chemical Name: Oxymetholone--434-07-1; Therapeutic Class: (68:08); AHFS Class: Androgens oxymetholone; References: 6; Publication Type: Correspondence; Journal Coden: BMJOAE; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - Reports on the possibility of the development of acute leukemia following oxymetholone therapy of patients with aplastic anemia are presented.
KW  - Oxymetholone--toxicity-;
KW  - Androgens--oxymetholone--toxicity, possible, development of leukemia in patients with aplastic anemia;
KW  - Toxicity--oxymetholone--possible, development of leukemia in patients with aplastic anemia;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Johnson, D. F.;
AU  - Lamontagne, N. S.;
AU  - Riggle, G. C.;
AU  - Anderson, F. O.;
T1  - Tape controlled gradient elution chromatography system for steroid analysis
CT  - Tape controlled gradient elution chromatography system for steroid analysis
JO  - Anal. Chem.
JF  - Anal. Chem.
Y1  - 1971/10/01/
VL  - 43
IS  - Oct
SP  - 1712
EP  - 1715
AD  - National Institutes of Health, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014
N1  - Accession Number: 9-0608; Language: English; References: 8; Journal Coden: ANCHAM; Section Heading: Pharmaceutical Chemistry
N2  - A punched tape system for gradient pumping of solvent mixtures with an accuracy of 0.2% is described. The pumping system for delivering preselected volumes of eluting solvents and a solvent mixing chamber design which minimizes volume carry-over when solvent ratios are changed are described. Application to column separation of adrenocortical and ketosteroids is illustrated. Block diagrams of the electronic and pumping system are included.
KW  - Chromatography--steroids, cortico---and ketosteroids, tape controlled gradient elution system;
KW  - Steroids, cortico---chromatography--tape controlled gradient elution system;
KW  - Automation, data processing--analysis--steroids, cortico-, and keto, tape controlled gradient elution chromatography system;
KW  - Steroids--keto---chromatography, tape controlled gradient elution system;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Roth, J.;
AU  - Prout, T. E.;
AU  - Goldfine, I. D.;
AU  - Wolfe, S. M.;
AU  - Muenzer, J.;
AU  - \ET/;
T1  - Sulfonylureas: effects in vivo and in vitro
CT  - Sulfonylureas: effects in vivo and in vitro
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1971/10/01/
VL  - 75
IS  - Oct
SP  - 607
EP  - 621
SN  - 00034819
AD  - National Institute of Arthritis and Metabolic Diseases, Bldg. 10, Room 8-S-243, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0573; Language: English; References: 70; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology; Abstract Author: Judith A. Kepler
N2  - The University Group Diabetes Program is reviewed and studies confirming the direct multiple effects of sulfonylureas in many tissue sites outside of the beta cell are discussed.
KW  - Sulfonylureas--effects--direct multiple, in tissue sites outside of beta cell;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Glynn, J. P.;
AU  - Kende, M.;
T1  - Treatment of Moloney virus-induced leukemia with cyclophosphamide and specifically sensitized allogeneic cells
CT  - Treatment of Moloney virus-induced leukemia with cyclophosphamide and specifically sensitized allogeneic cells
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1971/10/01/
VL  - 31
IS  - Oct
SP  - 1383
EP  - 1388
SN  - 00085472
AD  - Drug Evaluation Branch, Drug Research and Development, Chemotherapy, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-0127; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 24; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology; Abstract Author: Jimmie L. Hall
N2  - In this experiment, a combination of cyclophosphamide and immunotherapy with allogenic spleen cells was evaluated for antineoplastic effect against transplanted leukemia in mice. Cyclophosphamide followed within 4 to 6 hours by DBA/2 spleen cells from animals sensitized to Moloney virus yielded 44 long-term survivors out of 69 mice treated. This treatment was effective even though it was given only 2 to 6 days before the median survival time of untreated controls. No survivors were obtained with other forms of therapy.
KW  - Cyclophosphamide--and immunotherapy-;
KW  - Antineoplastic agents--cyclophosphamide--and immunotherapy, effects, against Moloney virus-induced leukemia, in mice;
KW  - Combined therapy--cyclophosphamide and immunotherapy--effects, against Moloney virus-induced leukemia, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Straus, M. J.;
AU  - Mantel, N.;
AU  - Goldin, A.;
T1  - Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210
CT  - Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1971/10/01/
VL  - 31
IS  - Oct
SP  - 1429
EP  - 1433
SN  - 00085472
AD  - Cancer Chemotherapy National Service Center, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-0113; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 25; Journal Coden: CNREA8; Section Heading: Pharmacology
N2  - This study was conducted to determine whether priming dose schedules of methotrexate could result in increased antileukemic effectiveness in mice. The results suggest that methotrexate has a greater percentage of cell kill at lower tumor cell populations. A cell cycle stage-specific agent such as methotrexate may kill a small percentage of tumor cells as the number of cells increases if there is either a corresponding decrease in growth fraction or an increase in mean generation time. In either case, a priming dose of methotrexate then may lower the tumor cell population sufficiently for subsequent low doses of the drug to kill more effectively.
KW  - Methotrexate--dosage schedules-;
KW  - Antineoplastic agents--methotrexate--dosage schedules, priming, effects, on mouse leukemia L1210 cells;
KW  - Dosage schedules--methotrexate--priming, effects, on mouse leukemia L1210 cells;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Paul, W. E.
AU  - Kask, Anne M.
T1  - Structural Control of Immunogenicity I. SYNTESIS OF <em>OLIGO</em>)-L-LYSINE PEPTIDES AND THEIR MONO-ε-DNP DERIVATIVES.
JO  - Immunology
JF  - Immunology
Y1  - 1971/10//
VL  - 21
IS  - 4
M3  - Article
SP  - 575
EP  - 582
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The synthesis of a series of oligo-L-lysines and mono-ε-DNP-oligo-L-lysines by Merrifield solid phase synthesis techniques has been described. The lysine utilized was protected at its α function by the highly acid-labile o-nitrophenyl-sulphenyl group and at its ε function by the benzyloxycarbonyl group. Thus, selective deprotection could be effected and the synthesis of the oligolysines was achieved with minimum side-product accumulation. The peptides were purified by ion exchange chromatography. More than twenty such compounds have been thus far prepared and have been utilized in the study of structural characteristics of immunogens and of the genetic control of the immune response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYSINE
KW  - SOLID-phase synthesis
KW  - IMMUNOLOGY
KW  - PEPTIDES
KW  - IMMUNE response
KW  - ORGANIC synthesis (Chemistry)
KW  - SYNTHESIS
N1  - Accession Number: 13363473; Paul, W. E. 1 Kask, Anne M. 1; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Oct71, Vol. 21 Issue 4, p575; Subject Term: LYSINE; Subject Term: SOLID-phase synthesis; Subject Term: IMMUNOLOGY; Subject Term: PEPTIDES; Subject Term: IMMUNE response; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: SYNTHESIS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yehudit Stupp
AU  - W. E. Paul
AU  - B. Benacerraf
T1  - Structural Control of Immunogenicity II. ANTIBODY SYNTHESIS AND CELLULAR IMMUNITY IN RESPONSE TO IMMUNIZATION WITH MONO-ε-<em>OLICO</em>-L-LYSINES.
JO  - Immunology
JF  - Immunology
Y1  - 1971/10//
VL  - 21
IS  - 4
M3  - Article
SP  - 583
EP  - 594
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A detailed evaluation of the capacity of mono-ε-DNP-oligo-L-lysines to initiate anti-DNP antibody synthesis and a state of delayed hypersensitivity in guinea-pigs is presented. Peptides containing as few as two lysine residues elicit the production of significant amounts of anti-DNP antibody when they are administered as Freund's complete adjuvant emulsions. Under these immunization conditions, the serum concentration of anti-DNP antibody is dependent on the chain length of the peptide, and on the amount and kind of mycobacteria in the adjuvant; guinea-pigs lacking the PLL gene produce amounts of anti-DNP antibody indistinguishable from that produced by guinea-pigs possessing this gene. On the other hand, when guinea-pigs are immunized with either 1-ε-DNP-tetra-L-lysine or 1-ε-DNP-nona-L-lysine without the use of mycobacterial adjuvant, anti-DNP antibody is produced only by guinea-pigs receiving the nona-L-lysine and only by those animals possessing the PLL gene. Delayed hypersensitivity results front immunizing PLL+ guinea-pigs with mono-ε-DNP-octa and nona-lysines but not from immunization with mono-εDNP-hexa-lysine; PLL- animals do not exhibit delayed hypersensitivity to any of these compounds. The data suggest that antibody synthesis to positively charged compounds may proceed as a result of formation of charge complexes with mycobacterial proteins; under such immunization conditions the intrinsic immunogenicity of a compound is more reliably revealed by the induction or elicitation of cellular immune responses. On this basis, a definite discontinuity in the degree of immunogenicity of the mono-ε-DNP-oligo-L-lysines occurs as the peptides are lengthened from six to eight residues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYSINE
KW  - IMMUNOGLOBULINS
KW  - ORGANIC synthesis (Chemistry)
KW  - GUINEA pigs
KW  - CELLULAR immunity
KW  - IMMUNIZATION
N1  - Accession Number: 13363499; Yehudit Stupp 1 W. E. Paul 2 B. Benacerraf 3; Affiliation:  1: Department of Immunology, Hebrew University, Hadassah Medical School, Jerusalem, Israel  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.  3: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, U.S.A.; Source Info: Oct71, Vol. 21 Issue 4, p583; Subject Term: LYSINE; Subject Term: IMMUNOGLOBULINS; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: GUINEA pigs; Subject Term: CELLULAR immunity; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stupp, Yehudit
AU  - Paul, W. E.
AU  - Benacerraft, B.
T1  - Structural Control of Immunogenicity III. PREPARATION FOR THE ELICITATION OF ANAMNESTIC ANTIBODY RESPONSES BY <em>OLIGO</em>- AND POLY-LYSINES AND THEIR DNP DERIVATIVES.
JO  - Immunology
JF  - Immunology
Y1  - 1971/10//
VL  - 21
IS  - 4
M3  - Article
SP  - 595
EP  - 603
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A complete evaluation of the immunogenicity of oligo-L-lysines and their mono-ε-DNP derivatives requires a determination of their capacity to prepare animals for secondary responses to a highly immunogenic analogue and to elicit secondary responses in animals prepared with such an analogue. It is shown here that 1-ε-DNP-tetra-L-lysine is not effective, or only marginally effective, in preparing PLL+ guinea-pigs for secondary anti-DNP responses to DNP-poly-L-lysine whereas 1-ε-DNP-nona-L-lysine is active in such preparation. Similarly, in animals primed to DNP-ovalbumin, supplemental immunization with tetra-L-lysine is not effective in preparing strain 2 guinea-pigs for a secondary anti-DNP response to DNP-poly-L-lysine whereas both nona-L-lysine and poly-L-lysine are effective, the latter to a considerably greater degree. In animals primed with DNP-poly-Llysine or with DNP-ovalbumin and poly-L-lysine, DNP-poly-L-lysine elicits secondary anti-DNP responses whereas neither 1-ε-DNP-nona-L-lysine or 1-εDNP-tetra-L-lysine do. The data indicate that a hierarchy in the degree of immunogenicity exists within the lysyl peptides series with poly-L-lysine more immunogenic than nona-L-lysine and this, in turn, more immunogenic than tetra-L-lysine which is either nonimmunogenic or marginally immunogenic. Further, the determination of immunogenicity is a feature either of the 'helper' cell population or of a step in the response which is prior to the activation of 'helper' cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYSINE
KW  - IMMUNOGLOBULINS
KW  - GUINEA pigs
KW  - IMMUNIZATION
KW  - IMMUNE response
KW  - DINITROBENZENES
N1  - Accession Number: 13363523; Stupp, Yehudit 1 Paul, W. E. 2 Benacerraft, B. 3; Affiliation:  1: Department of Immunology, Hebrew University, Hadassah Medical School, Jerusalem, Israel  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.  3: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, Israel; Source Info: Oct71, Vol. 21 Issue 4, p595; Subject Term: LYSINE; Subject Term: IMMUNOGLOBULINS; Subject Term: GUINEA pigs; Subject Term: IMMUNIZATION; Subject Term: IMMUNE response; Subject Term: DINITROBENZENES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Paul, W. E.
AU  - Stupp, Yehudit
AU  - Siskind, G. W.
AU  - Benacerraf, B.
T1  - Structural Control of Immunogenicity IV. RELATIVE SPECIFICITY OF ELICITATION OF CELLULAR IMMUNE RESPONSES AND OF LIGAND BINDING TO ANTI-HAPTEN ANTIBODY AFTER IMMUNIZATION WITH MONO-ε-DNP-<em>NONA</em>-L-LYSINE.
JO  - Immunology
JF  - Immunology
Y1  - 1971/10//
VL  - 21
IS  - 4
M3  - Article
SP  - 605
EP  - 616
PB  - Wiley-Blackwell
SN  - 00192805
AB  - An evaluation of the specificity of antigen binding receptors possessed by cells involved in cellular immune responses and by cells in the antibody synthesizing line was made in order to determine to what extent each cell type could distinguish between closely related mono-ε-DNP-oligo-L-lysines. The antigen binding receptors of cells involved in cellular immune responses were studied by the elicitation of delayed hypersensitivity reactions in vivo and by the stimulation of DNA synthesis by lymph node cells in vitro using 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. These experiments demonstrated that closely related compounds could be distinguished by this cell population. On the other hand, serum antibody from animals immunized with 1-ε-DNP-nona-L-lysine did not regularly distinguish between various mono-ε-DNP-oligo-L-lysines of differing immunogenicity or between 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. Serum antibody specificity is assumed to reflect the specificity of the receptors possessed by the precursors of antibody producing cells. Thus, it appears likely that the cells involved in cellular immune responses or functioning as 'helper' cells in the stimulation of antibody synthesis by other cells are capable of determining the immunogenicity of a compound. On the other hand, precursors of antibody producing cells, at least in primed animals and in the mono-ε-DNP-oligo-L-lysine response, do not appear to make distinctions between peptides of differing immunogenicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - CELLULAR immunity
KW  - IMMUNOGLOBULINS
KW  - LIGAND binding (Biochemistry)
KW  - IMMUNIZATION
KW  - DINITROBENZENES
N1  - Accession Number: 13363557; Paul, W. E. 1 Stupp, Yehudit 2 Siskind, G. W. 3 Benacerraf, B. 4; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20014 and Division of Allergy and Immunology, Department of Medicine, Cornell Medical College, New York, U.S.A.  2: Department of Immunology, Hebrew Univ., Hadassah Medical School, Jerusalem, Israel  3: Career Scientist of the Health Research Council of the City of New york (Research Investigatorship I-593)  4: Department of Pathology, Harvard Medical School, Boston, Massachusetts, U.S.A.; Source Info: Oct71, Vol. 21 Issue 4, p605; Subject Term: IMMUNE response; Subject Term: CELLULAR immunity; Subject Term: IMMUNOGLOBULINS; Subject Term: LIGAND binding (Biochemistry); Subject Term: IMMUNIZATION; Subject Term: DINITROBENZENES; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Paul, W. E.
AU  - Stupp, Yehudit
AU  - Siskind, G. W.
AU  - Benacerraf, B.
T1  - Structural Control of Immunogenicity IV. RELATIVE SPECIFICITY OF ELICITATION OF CELLULAR IMMUNE RESPONSES AND OF LIGAND BINDING TO ANTI-HAPTEN ANTIBODY AFTER IMMUNIZATION WITH MONO-ε-DNP-<em>NONA</em>-L-LYSINE.
JO  - Immunology
JF  - Immunology
Y1  - 1971/10//
VL  - 21
IS  - 4
M3  - Article
SP  - 605
EP  - 616
SN  - 00192805
AB  - An evaluation of the specificity of antigen binding receptors possessed by cells involved in cellular immune responses and by cells in the antibody synthesizing line was made in order to determine to what extent each cell type could distinguish between closely related mono-ε-DNP-oligo-L-lysines. The antigen binding receptors of cells involved in cellular immune responses were studied by the elicitation of delayed hypersensitivity reactions in vivo and by the stimulation of DNA synthesis by lymph node cells in vitro using 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. These experiments demonstrated that closely related compounds could be distinguished by this cell population. On the other hand, serum antibody from animals immunized with 1-ε-DNP-nona-L-lysine did not regularly distinguish between various mono-ε-DNP-oligo-L-lysines of differing immunogenicity or between 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. Serum antibody specificity is assumed to reflect the specificity of the receptors possessed by the precursors of antibody producing cells. Thus, it appears likely that the cells involved in cellular immune responses or functioning as 'helper' cells in the stimulation of antibody synthesis by other cells are capable of determining the immunogenicity of a compound. On the other hand, precursors of antibody producing cells, at least in primed animals and in the mono-ε-DNP-oligo-L-lysine response, do not appear to make distinctions between peptides of differing immunogenicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - CELLULAR immunity
KW  - IMMUNOGLOBULINS
KW  - LIGAND binding (Biochemistry)
KW  - IMMUNIZATION
KW  - DINITROBENZENES
N1  - Accession Number: 13363557; Paul, W. E. 1; Stupp, Yehudit 2; Siskind, G. W. 3; Benacerraf, B. 4; Source Information: Oct71, Vol. 21 Issue 4, p605; Subject: IMMUNE response; Subject: CELLULAR immunity; Subject: IMMUNOGLOBULINS; Subject: LIGAND binding (Biochemistry); Subject: IMMUNIZATION; Subject: DINITROBENZENES; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 1972-07387-001
AN  - 1972-07387-001
AU  - Symmes, Jean S.
T1  - Visual imagery in brain-injured children.
JF  - Perceptual and Motor Skills
JO  - Perceptual and Motor Skills
JA  - Percept Mot Skills
Y1  - 1971/10//
VL  - 33
IS  - 2
SP  - 507
EP  - 514
CY  - US
PB  - Perceptual & Motor Skills
SN  - 0031-5125
SN  - 1558-688X
N1  - Accession Number: 1972-07387-001. PMID: 5124106 Other Journal Title: Perceptual & Motor Skills Research Exchange. Partial author list: First Author & Affiliation: Symmes, Jean S.; National Institutes of Health, Inst. of Child Health & Human Development, Bethesda, Md. Other Publishers: Sage Publications. Release Date: 19720401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain Damage; Imagery; Intelligence Quotient; Perceptual Aftereffect; Visual Perception. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 8. Issue Publication Date: Oct, 1971. 
AB  - Investigated the incidence of eidetic imagery and prolonged after-imagery in 37 5-14 yr. Old retardates. Incidence of eidetic imagery was 19%, significantly higher than normal samples, and all ss with eidetic imagery were classified as 'brain-injured' by common neurological diagnostic criteria. Ss with long, stable afterimages had a significantly higher mean iq than those with short afterimages, capacity for fixation and task learning being controlled. A possible explanation of the iq discrepancy is presented in terms of how a longer time to process visual input into short-term memory may be functional for children of low intelligence. (15 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - eidetic imagery & prolonged after-imagery
KW  - IQ
KW  - brain-injured 5-14 yr. olds
KW  - 1971
KW  - Brain Damage
KW  - Imagery
KW  - Intelligence Quotient
KW  - Perceptual Aftereffect
KW  - Visual Perception
KW  - 1971
DO  - 10.2466/pms.1971.33.2.507
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40831-015
AN  - 2013-40831-015
AU  - Shore, Milton F.
T1  - Whither child advocacy?
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1971/10//
VL  - 41
IS  - 5
SP  - 798
EP  - 798
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40831-015. PMID: 5118565 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Advocacy; Childhood Development; Family Relations; Mental Health. Minor Descriptor: Agency. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Page Count: 1. Issue Publication Date: Oct, 1971. 
AB  - The current interest in child advocacy was generated by the work of the Joint Commission on the Mental Health of Children. The Commission was eager to mobilize the country not only to improve existing services for children, but to generate community concern and involvement to establish new and better structures to facilitate healthy child development. The state and local child advocates would work closely with Federal agencies, perhaps as an Advocacy Council, to foster programs for children and their families. In order to make all levels ultimately accountable to the people, and to commit the country to a massive improvement in the children's area, perhaps a tradition should also be started requesting the President to report to Congress through a special message. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child advocacy
KW  - mental health
KW  - child development
KW  - family dynamics
KW  - Federal agencies
KW  - 1971
KW  - Advocacy
KW  - Childhood Development
KW  - Family Relations
KW  - Mental Health
KW  - Agency
KW  - 1971
DO  - 10.1111/j.1939-0025.1971.tb00744.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40831-022
AN  - 2013-40831-022
AU  - Katz, Martin M.
T1  - Problems of training in the application of a new system of classification for the psychosocial disorders.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1971/10//
VL  - 41
IS  - 5
SP  - 841
EP  - 843
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-40831-022. PMID: 5118572 Partial author list: First Author & Affiliation: Katz, Martin M.; Clinical Research Branch, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Adjustment; Experimental Design; Mental Disorders; Psychosocial Development. Minor Descriptor: Behavior; Judgment; Taxonomies. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1971. 
AB  - In this article, procedures reduce the influence of 'irrelevant' sources of variance and extend the sample of behavior upon which judgments can be based. The authors await the development of more objective methods for measuring these emotional and behavioral qualities, methods that will permit us to eventually dispense with the need for subjective judgment. Since it will be well into the future before that effort succeeds in providing sufficiently sensitive and feasible methods for routine application, it will help to turn to and to encourage the use of other observational sources and settings and more standardized examination procedures for the clinical interview itself. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychosocial disorders
KW  - behavioral qualities
KW  - emotional qualities
KW  - clinical interviews
KW  - standardized examination
KW  - 1971
KW  - Emotional Adjustment
KW  - Experimental Design
KW  - Mental Disorders
KW  - Psychosocial Development
KW  - Behavior
KW  - Judgment
KW  - Taxonomies
KW  - 1971
DO  - 10.1111/j.1939-0025.1971.tb00751.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Lowy, D. R.
AU  - ROWE, W. P.
AU  - TEICH, N.
AU  - HARTLEY, J. W.
T1  - Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-Bromodeoxyuridine.
JO  - Science
JF  - Science
Y1  - 1971/10/08/
VL  - 174
IS  - 4005
M3  - Article
SP  - 155
EP  - 156
SN  - 00368075
AB  - Cells of emnbryos of the high leukemnic inotise strain AKR can be grown in clultlure as virus-negative cell lines. However, these lines and clonal sublites uniform-1ly have the capacily to initiate synthesis of mnurine leukemia virus. Exposure of the cells to 5-iododeoxyltridine or 5-bromodcoxyuridine induced synthesis of viruts in as high as 0.1 to 0.5 percent of the cells; nmany of the cells were producing virus as soon as 3 days after initiation of treatment. Itndluclion of virtis by these drujgs is severcil orders of magnitude greater thanl that obtaimied with any other treatment tested. These stuidies indicat that the genomne of murine leuikemnia virus is present in an linexpressed form in all AKR cells and provide a potentially powered technique for activating lelukemnia virus genomes in other cell systemtis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002559; Lowy, D. R. 1; ROWE, W. P. 1; TEICH, N. 1; HARTLEY, J. W. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 10/ 8/1971, Vol. 174 Issue 4005, p155; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - AARONSON, STUART A.
AU  - TODARO, GEORGE J.
AU  - SCOLNICK, EDWARD M.
T1  - Induction of Murine C-Type Viruses from Clonal Lines of Virus-Free BALB/3T3 Cells.
JO  - Science
JF  - Science
Y1  - 1971/10/08/
VL  - 174
IS  - 4005
M3  - Article
SP  - 157
EP  - 159
SN  - 00368075
AB  - Each clone of BALBIc mouse embryo cells that has been tested can be induced to form C-type virus. The individual cells therefore contain a complete copy of the genetic information for making the murine RNA tumor viruses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002560; AARONSON, STUART A. 1; TODARO, GEORGE J. 1; SCOLNICK, EDWARD M. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/ 8/1971, Vol. 174 Issue 4005, p157; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BROWN, JOEL E.
AU  - MULLER, KENNETH J.
AU  - MURRAY, GEORGE
T1  - Reversal Potential for an Electrophysiological Event Generated by Conductance Changes: Mathematical Analysis.
JO  - Science
JF  - Science
Y1  - 1971/10/15/
VL  - 174
IS  - 4006
M3  - Article
SP  - 318
EP  - 318
SN  - 00368075
N1  - Accession Number: 87634311; BROWN, JOEL E. 1; MULLER, KENNETH J. 1; MURRAY, GEORGE 2; Affiliations: 1: Department of Biology and Research Laboratory of Technology, Massachusetts Institute of Technology, Cambridge 02139; 2: Laboratory of Neurophysiology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/15/1971, Vol. 174 Issue 4006, p318; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Wyatt, R. J.;
AU  - Fram, D. H.;
AU  - Buchbinder, R.;
AU  - Snyder, F.;
T1  - Treatment of intractable narcolepsy with a monoamine oxidase inhibitor
CT  - Treatment of intractable narcolepsy with a monoamine oxidase inhibitor
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/10/28/
VL  - 285
IS  - Oct 28
SP  - 987
EP  - 991
SN  - 00284793
AD  - National Institute of Mental Health, Building 10, Room 3N262, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 9-1658; Language: English; Chemical Name: Phenelzine--51-71-8; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants phenelzine; References: 20; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Seven patients with intractable narcolepsy were treated with phenelzine. Striking reductions in the amount of cataplectic attacks, sleep paralysis and hypnagogic hallucinations were noted. In addition, daytime sleeping and hypersomnia were diminished, but side effects (hypotension, edema, impaired sexual function) were bothersome. Phenelzine almost completely suppressed rapid eye movement (REM) sleep and remained effective for periods of more than a year. Although dreams were frequently reported before drug treatment, no dreams were reported when REM sleep was completely absent. No adverse psychologic effects were noted during the period of total REM suppression.
KW  - Phenelzine--narcolepsy-;
KW  - Antidepressants--phenelzine--narcolepsy, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Howe, Warren P.
AU  - Cargille, Charles M.
AU  - Dodge, Lowell
T1  - Proposal for an Auto Safety Directory.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1971/11//
VL  - 61
IS  - 11
M3  - Letter
SP  - 2163
EP  - 2163
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented about the proposal for a motor vehicle safety directory.
KW  - Letters to the editor
KW  - Directories
N1  - Accession Number: 24851708; Howe, Warren P. 1; Cargille, Charles M. 2; Dodge, Lowell 3; Affiliations: 1: National Association of Counties Research Foundation, D.C.; 2: National Institute of Child Health and Human Development, Md.; 3: Center for Auto Safety Washington, D.C.; Issue Info: Nov1971, Vol. 61 Issue 11, p2163; Subject Term: Letters to the editor; Subject Term: Directories; NAICS/Industry Codes: 511140 Directory and Mailing List Publishers; Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Milne, G. W. A.;
AU  - Fales, H. M.;
AU  - Axenrod, T.;
T1  - Identification of dangerous drugs by isobutane chemical ionization mass spectrometry
CT  - Identification of dangerous drugs by isobutane chemical ionization mass spectrometry
JO  - Anal. Chem.
JF  - Anal. Chem.
Y1  - 1971/11/01/
VL  - 43
IS  - Nov
SP  - 1815
EP  - 1820
AD  - Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-0630; Language: English; References: 17; Journal Coden: ANCHAM; Section Heading: Drug Analysis
N2  - The isobutane chemical ionization mass spectra of 48 commonly used drugs have been measured. The majority of these give only an MH\SU/+ \BS/ion which can be used to identify the compound. In a few cases, the fragmentation of the MH\SU/+ \BS/ion is observed and can be rationalized in terms of simple acid-catalyzed reactions. Examples of the use of this technique in the identification of drugs taken in overdose quantities by patients admitted to a hospital are provided. Drugs analyzed included analgesics, barbiturates and tranquilizers.
KW  - Spectrometry--mass--isobutane chemical ionization, in identification of drugs;
KW  - Barbiturates--spectrometry--mass, isobutane chemical ionization;
KW  - Analgesics and antipyretics--spectrometry--mass, isobutane chemical ionization;
KW  - Tranquilizers--spectrometry--mass, isobutane chemical ionization;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T., Jr.;
AU  - Carbone, P. P.;
T1  - Chemotherapeutic implications of staging in Hodgkin's disease
CT  - Chemotherapeutic implications of staging in Hodgkin's disease
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1971/11/01/
VL  - 31
IS  - Nov
SP  - 1838
EP  - 1844
SN  - 00085472
AD  - Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1513; Language: English; Chemical Name: Mechlorethamine--51-75-2 Chlorambucil--305-03-3 Cyclophosphamide--6055-19-2 Vincristine--57-22-7 Procarbazine--671-16-9 Prednisone--53-03-2; References: 29; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Jimmie L. Hall
N2  - This article discusses the use of mechlorethamine, chlorambucil, cyclophosphamide, vincristine, procarbazine, and prednisone, or combinations of these, in the treatment of Hodgkin's disease.
KW  - Mechlorethamine--Hodgkin's disease-;
KW  - Chlorambucil--Hodgkin's disease-;
KW  - Cyclophosphamide--Hodgkin's disease-;
KW  - Vincristine--Hodgkin's disease-;
KW  - Procarbazine--Hodgkin's disease-;
KW  - Prednisone--Hodgkin's disease-;
KW  - Antineoplastic agents--alone or in combination--Hodgkin's disease, therapy, discussion;
KW  - Combined therapy--antineoplastic agents--Hodgkin's disease, discussion;
KW  - Antineoplastic agents--Hodgkin's disease--therapy, alone or in combination, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Feldmann, Richard J
AU  - Heller, Stephen R
AU  - Shapiro, Kenneth P
T1  - An experimental computerized cbac search project
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1971/11//
VL  - 11
IS  - 4
M3  - Article
SP  - 248
EP  - 251
SN  - 00219576
AB  - A literature search system for cbac is described. Both sdi and retrospective searching techniques are available to the user. The system relies heavily on searching keywords from the cbac text rather than the text itself and employs batch/tape and time-sharing disk hardware.
N1  - Accession Number: ISTA0700642; Feldmann, Richard J 1; Heller, Stephen R; Shapiro, Kenneth P; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: November 1971, Vol. 11 Issue 4, p248; Note: Update Code: 0700; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Symmes, David
AU  - Eisengart, Marvin A.
T1  - EVOKED RESPONSE CORRELATES OF MEANINGFUL VISUAL STIMULI IN CHILDREN.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1971/11//
VL  - 8
IS  - 6
M3  - Article
SP  - 769
EP  - 778
SN  - 00485772
AB  - Photographic slides of familiar objects or cartoons were tachistoscopically presented to a group of 79 normal children (age 5-11 years) in a study of the evoked response correlates of meaningful visual stimuli. Control stimuli consisted of blank slides or defocused cartoons matched for brightness. A warning flash preceded the slides by 1 sec. EEG and eye movement potentials were recorded on line with a 9.5 sec time constant and averaged off-line. The principal finding was a vertex negative slow potential peaking about 500 msec after slide presentation which correlated with reports of interest in and recall of both objects and cartoons. Responses in the occipital region changed less consistently with pictorial material, and were the same to the warning flash whether it preceded control or test stimuli. The vertex negative response appears to be a corollary of perceptual integration of meaningful stimuli. Among alternative explanations nonspecific differences in arousal level and/or expectancy appear to be unlikely on the basis of our data. A primary role of edge contrast in generating these late negative responses would not be predicted on the basis of published evidence, but our attempt to control for this alternative yielded equivocal results. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VISUAL evoked response
KW  - ELECTROENCEPHALOGRAPHY
KW  - CHILDREN
KW  - PSYCHOPHYSIOLOGY
N1  - Accession Number: 11056523; Symmes, David 1 Eisengart, Marvin A. 1; Affiliation:  1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: Nov1971, Vol. 8 Issue 6, p769; Subject Term: VISUAL evoked response; Subject Term: ELECTROENCEPHALOGRAPHY; Subject Term: CHILDREN; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ALLEVA, JOHN J.
AU  - ALLEVA, FREDERIC R.
AU  - FRY JR., BERT E.
AU  - EANES, EDWARD D.
T1  - Calcium Carbonate Concretions: Cyclic Occurrence in the Hamster Vagina.
JO  - Science
JF  - Science
Y1  - 1971/11/05/
VL  - 174
IS  - 4009
M3  - Article
SP  - 600
EP  - 603
SN  - 00368075
AB  - Three crystalline forms of calcium carbonate were identified in washings of the hamster vagina. Spherical concretions of vaterite and hexagonal concretions of calcite predominate on days 3 and 4 of the 4-day estrous cycle. Dumbbell-like concretions of aragonite predominate during pregnancy and pseudopregnancy. Each polymorph is associated with an acid-insoluble matrix. Concretions disappear after ovariectomy and reappear during daily injections of estrogen and progesterone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002637; ALLEVA, JOHN J. 1; ALLEVA, FREDERIC R. 1; FRY JR., BERT E. 1; EANES, EDWARD D. 2; Affiliations: 1: Food and Drug Administration, Departmenit of Health, Education, and Welfare, Washington, D.C. 20204; 2: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/ 5/1971, Vol. 174 Issue 4009, p600; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WILLIMS, R. B.
AU  - EICHELMAN, B.
T1  - Social Setting: Influence on the Physiological Response to Electric Shock in the Rat.
JO  - Science
JF  - Science
Y1  - 1971/11/05/
VL  - 174
IS  - 4009
M3  - Article
SP  - 613
EP  - 614
SN  - 00368075
AB  - A significant fall in tail blood pressure occurs in paired rats after shock-induced aggression. Pressure returns to baseline levels within 4 hours after fighting. Conversely, single rats subjected to jump threshold measurements or to shocks identical to those used in the aggression paradigm show significant elevations in tail blood pressure. The size of the pressure increase in rats shocked alone appears dependent on the intensity of the shocks, while the pressure fall in rats shocked in pairs occurs over a broad range of shock intensities. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002642; WILLIMS, R. B. 1; EICHELMAN, B. 1; Affiliations: 1: Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 11/ 5/1971, Vol. 174 Issue 4009, p613; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dunn, T. B.;
T1  - Carcinogenic action of estrogens
CT  - Carcinogenic action of estrogens
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/11/11/
VL  - 285
IS  - Nov 11
SP  - 1147
SN  - 00284793
AD  - National Cancer Institute, Bethesda, Maryland
N1  - Accession Number: 9-1205; Language: English; Trade Name: Enovid; Generic Name: Norethynodrel; Chemical Name: Diethylstilbestrol--56-53-1 Norethynodrel--68-23-5 Mestranol--72-33-3; Therapeutic Class: (68:12); AHFS Class: Contraceptives, oral norethynodrel, combination, mestranol (68:16); AHFS Class: Estrogens diethylstilbestrol; Publication Type: Correspondence; Journal Coden: NEJMAG; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - Results obtained by injecting diethylstilbestrol or norethynodrel with mestranol (Enovid) into newborn mice are presented. The animal experiments suggest that if immature individuals of either human or animal species are exposed to an excess of estrogen, cancer may develop.
KW  - Diethylstilbestrol--toxicity-;
KW  - Norethynodrel--combination, mestranol-;
KW  - Mestranol--combination, norethynodrel-;
KW  - Contraceptives, oral--norethynodrel, combination, mestranol--injections, possible carcinogenic activity, in mice;
KW  - Estrogens--diethylstilbestrol--injections, possible carcinogenic activity, in mice;
KW  - Toxicity--diethylstilbestrol--injections, studies, possible carcinogenic activity, in mice;
KW  - Toxicity--norethynodrel, combination, mestranol--injections, studies, possible carcinogenic activity, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - BURKE, R. E.
AU  - LEVINE, D. N.
AU  - ZAJAC III, F. E.
AU  - TSAIRIS, P.
AU  - ENGEL, W. K.
T1  - Mammalian Motor Units: Physiological-Histochemical Correlation in Three Types in Cat Gastrocnemius.
JO  - Science
JF  - Science
Y1  - 1971/11/12/
VL  - 174
IS  - 4010
M3  - Article
SP  - 709
EP  - 712
SN  - 00368075
AB  - The correlation among a variety of physiological properties and the histochemical characteristics of muscle fibers belonging to single motor units in a mixed mammalian muscle is directly demonstrated. The population of motor units making up the cat gastrocnemius was classified into three nonoverlapping groups on the basis of a combination of physiological parameters. The muscle fibers belonging to motor units of each physiological type exhibited a distinctive histochemical profile, such that the three basic histochemical "fiber types" exactly matched the three physiologically defined groups. Within each individual motor unit, the muscle fibers were histochemically uniform. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002676; BURKE, R. E. 1; LEVINE, D. N. 1; ZAJAC III, F. E. 1; TSAIRIS, P. 2; ENGEL, W. K. 2; Affiliations: 1: Laboratory of Neural Control, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 2: Medical Neurology Branch, National Institute of Neurological Diseases and Stroke; Issue Info: 11/12/1971, Vol. 174 Issue 4010, p709; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GLENNER, G. G.
AU  - EIN, D.
AU  - EANES, E. D.
AU  - BLADEN, H. A.
AU  - TERRY, W.
AU  - PAGE, D. L.
T1  - Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro.
JO  - Science
JF  - Science
Y1  - 1971/11/12/
VL  - 174
IS  - 4010
M3  - Article
SP  - 712
EP  - 714
SN  - 00368075
AB  - "Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, β-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002677; GLENNER, G. G. 1; EIN, D. 1; EANES, E. D. 1; BLADEN, H. A. 1; TERRY, W. 1; PAGE, D. L. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/12/1971, Vol. 174 Issue 4010, p712; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Adamson, R. H.;
T1  - Antileukemic activity of hycanthone
CT  - Antileukemic activity of hycanthone
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1971/11/27/
VL  - 2
IS  - Nov 27
SP  - 1206
SN  - 00237507
AD  - Section of Pharmacology and Experimental Therapeutics, Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-1508; Language: English; Chemical Name: Hycanthone--3105-97-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents hycanthone; References: 7; Publication Type: Letters to the Editor; Journal Coden: LANCAO; Section Heading: Preliminary Drug Testing; Abstract Author: Douglas L. Thompson
N2  - Hycanthone methanesulfonate showed cytotoxic activity in vitro and in vivo against leukemia L1210 and P388. Since this drug has shown a low toxicity in the therapy of schistosomiasis in patients, it is suggested that this compound should be evaluated for activity against leukemia in man.
KW  - Hycanthone--methanesulfonate-;
KW  - Antineoplastic agents--hycanthone--methanesulfonate, in vitro and in vivo, in mice;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - Bluming, A. Z.
AU  - Ziegler, J. L.
AU  - Fass, L.
AU  - Herberman, R. B.
T1  - DELAYED CUTANEOUS SENSITIVITY REACTIONS TO AUTOLOGOUS BURKITT LYMPHOMA PROTEIN EXTRACTS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1971/12//
VL  - 9
IS  - 6
M3  - Article
SP  - 713
EP  - 719
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Positive delayed cutaneous sensitivity reactions to protein extracts of autologous Burkitt lymphoma cells were observed in fifteen of thirty patients tested in clinical systemic remission and in only one of sixteen patients tested with active extradural disease. Positive responding patients who eventually relapsed had significantly longer remission durations than did their negative responding counterparts. Seven patients with positive reactions were negative when retested in relapse. Positive reactions were not observed at extract protein concentrations of 01 mg/ml and were maximally evident at 1 mg/ml. Negative skin tests could not be attributed to generalized anergy because of the simultaneous observation of positive reactions to common antigens in over half the negative responders. Cutaneous reactivity to autologous tumour extract may serve as a sensitive test for extradural disease activity, and, because of its association with remission duration, suggests a role for the specifically sensitized lymphocyte in tumour regression and prognosis. [ABSTRACT FROM AUTHOR]
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KW  - B cells -- Tumors
KW  - LYMPHOMAS
KW  - DISEASES
KW  - PROGNOSIS
KW  - ANTIGENS
KW  - PATIENTS
N1  - Accession Number: 14541768; Bluming, A. Z. 1,2 Ziegler, J. L. 1,2 Fass, L. 1,2 Herberman, R. B. 1,2; Affiliation:  1: Lymphoma Treatmen Centre, Department of Surgery, Makerere University College Medical School, Kampala, Uganda  2: Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S. A.; Source Info: Dec71, Vol. 9 Issue 6, p713; Subject Term: B cells -- Tumors; Subject Term: LYMPHOMAS; Subject Term: DISEASES; Subject Term: PROGNOSIS; Subject Term: ANTIGENS; Subject Term: PATIENTS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Kirkpatrick, C. H.
AU  - Rich, R. R.
AU  - Graw Jr, R. G.
AU  - Smith, T. K.
AU  - Irad Mickenberg
AU  - Rogentine, G. N.
T1  - TREATMENT OF CHRONIC MUCOCUTANEOUS MONILIASIS BY IMMUNOLOGIC RECONSTITUTION.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1971/12//
VL  - 9
IS  - 6
M3  - Article
SP  - 733
EP  - 748
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The immunological defect in a patient with chronic mucocutaneous moniliasis was characterized. While his Candida skin test was negative, exposure of his lymphocytes to candida extracts in vitro produced an increase in thymidine incorporation. Supernatants from cultures of antigen-stimulated lymphocytes did not contain macrophage migration-inhibition factor (MIF) activity. Restoration of the immune system with transfusions of immuno-competent allogeneic lymphocytes was accompanied by conversion of the Candida skin test to positive, and MW production by his lymphocytes. During the period that his immune system remained intact, there was marked clearing of the moniliasis. Eight months following the transfusions, the moniliasis recurred and when restudied, the patient again had negative skin tests and insignificant MIF production. These observations demonstrate the importance of mediators in the expression of delayed hypersensitivity and provide evidence of a role of cellular immunity in resistance to certain chronic fungal infections. [ABSTRACT FROM AUTHOR]
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KW  - CANDIDIASIS
KW  - MUCOUS membrane -- Diseases
KW  - LYMPHOCYTES
KW  - THYMIDINE
KW  - MYCOSES
KW  - CANDIDA
N1  - Accession Number: 14541825; Kirkpatrick, C. H. 1,2 Rich, R. R. 1,2 Graw Jr, R. G. 1,2 Smith, T. K. 1,2 Irad Mickenberg 1,2 Rogentine, G. N. 1,2; Affiliation:  1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U. S. A.  2: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, U. S. A.; Source Info: Dec71, Vol. 9 Issue 6, p733; Subject Term: CANDIDIASIS; Subject Term: MUCOUS membrane -- Diseases; Subject Term: LYMPHOCYTES; Subject Term: THYMIDINE; Subject Term: MYCOSES; Subject Term: CANDIDA; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ellman, L.
AU  - Inman, J.
AU  - Green, Ira
T1  - STRAIN DIFFERENCE IN THE IMMUNE RESPONSE TO HYDRALAZINE IN INBRED GUINEA-PIGS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1971/12//
VL  - 9
IS  - 6
M3  - Article
SP  - 927
EP  - 937
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Guinea-pigs were immunized with hydralazine in Freund's complete adjuvant. A marked strain difference in the immune response involving both anti-hydralazine antibody and delayed hypersensitivity to hydralazine was observed in different strains of guinea-pigs: Hartley guinea-pigs and inbred strain 13 guinea-pigs were able to mount a vigorous immune response to the drug while inbred strain 2 guinea-pigs appeared to be 'low or non-responders'. This difference could not be explained in terms of metabolism of the drug in that no differences in acetylation were observed. Breeding studies suggest that immune responsiveness to hydralazine is inherited in an autosomal dominant manner. The immune response to hydralazine may be controlled by a 'specific immune response gene' which appears not to be linked to the major strain 13 histocompatibility gene. Anti-nuclear and anti-DNA antibodies could not be demonstrated at a time when the animals manifested a strong immune response to hydralazine. Thus, the development of auto-immune phenomena does not appear to be related to the development of an immune response to the drug in short term immunization. Hydralazine-protein conjugates were synthesized, radio-iodinated and used in a Farr technique for the measurement of anti-hydralazine antibody. These techniques for the assay of anti-hydralazine antibodies may be useful in clinical investigations. [ABSTRACT FROM AUTHOR]
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KW  - HYDRALAZINE
KW  - METABOLISM
KW  - GUINEA pigs
KW  - CARDIOVASCULAR agents
KW  - IMMUNE response
KW  - GENES
N1  - Accession Number: 14542409; Ellman, L. 1 Inman, J. 1 Green, Ira 1; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Dec71, Vol. 9 Issue 6, p927; Subject Term: HYDRALAZINE; Subject Term: METABOLISM; Subject Term: GUINEA pigs; Subject Term: CARDIOVASCULAR agents; Subject Term: IMMUNE response; Subject Term: GENES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schrogie, J. J.;
T1  - Facilities available for surveillance of the side effects of fertility regulating agents in the United States
CT  - Facilities available for surveillance of the side effects of fertility regulating agents in the United States
JO  - Contraception (USA)
JF  - Contraception (USA)
Y1  - 1971/12/01/
VL  - 4
IS  - Dec
SP  - 401
EP  - 409
SN  - 00107824
AD  - Fertility Regulating Methods Evaluation Branch Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
N1  - Accession Number: 10-1920; Language: English; References: 12; Journal Coden: CCPTAY; Section Heading: Information Processing and Literature; Sociology, Economics and Ethics
N2  - A number of techniques utilizing currently available facilities may be employed to assess the extent of use and side effects of contraceptive agents. Interpretation of vital statistics and survey information describes trends in mortality from selected causes and choice of contraceptive agent. The use of adverse drug reaction surveillance and multiphasic screening programs may identify more specific relationships between drugs, devices and diseases. Such findings may stimulate the development of in depth clinical evaluations or epidemiological studies of specific subjects such as thromboembolism and cancer. A number of representative studies are identified which may yield information not only describing elements of risk but also of demographic value. Full and coordinated use of these opportunities for information gathering will generate more accurate assessments of contraceptive status in large populations and form a more adequate baseline for future evaluations.
KW  - Drug information--contraceptives, oral--sources, for surveillance of side effects, in U.S.;
KW  - Toxicity--contraceptives, oral--side effects, sources, available for surveillance, in U.S.;
KW  - Contraceptives, oral--toxicity--side effects, information, sources, available for surveillance, in U.S.;
KW  - Statistics--contraceptives, oral--side effects, sources of available information;
KW  - Drugs, adverse reactions--contraceptives, oral--information, sources available for surveillance, in U.S.;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
T1  - THE ATTRIBUTION BY OPIATE ADDICTS OF CHARACTERISTICS TO ADDICT SUBGROUPS AND TO SELF.
AU  - Monroe, Jack J.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1971/12//
VL  - 85
IS  - 2
SP  - 239
EP  - 249
SN  - 00224545
N1  - Accession Number: 16471462; Author: Monroe, Jack J.: 1 ; Author Affiliation: 1 National Institute of Mental Health, Lexington, Kentucky.; No. of Pages: 11; Language: English; Publication Type: Article; Update Code: 20050323
N2  - The purpose of this paper was to demonstrate the applicability of perceived similarity and social favorability scales to the assessment of reference group valences in opiate addicts. Parallel sets of questionnaire items were constructed to elicit favorable and unfavorable self-presentations and group assessments on three status dimensions where in each dimension one pole represented a specified membership group presumed to be a positive reference group, while the other pole symbolized a contrasting, and presumably negative reference group. An item by item scoring of congruent responses to pairs cif items describing self and designated subgroups yielded measures of addict identification or psychological closeness of addicts with reference groups. Configurally scored scales were not superior to single response scales in differentiating the valence levels of reference groups. Greater favorability was ascribed to membership groups. Subjects tended to attribute unfavorable qualities (and in some cases tended to neutralize their responses) to nonmembership groups. ABSTRACT FROM AUTHOR
KW  - *SOCIAL psychology
KW  - REFERENCE groups
KW  - SOCIAL groups
KW  - SOCIAL interaction
KW  - MEMBERSHIP
KW  - BEHAVIOR
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
AU  - Kiefer, James E.
AU  - Weiss, George H.
T1  - A Truncated Test for Choosing the Better of Two Binomial Populations.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1971/12//
VL  - 66
IS  - 336
M3  - Article
SP  - 867
SN  - 01621459
AB  - It is shown that a test suggested by Bechhofer, Kiefer, and Sobel [1], for selecting the better of two binomial populations, can be formulated and solved when a maximum number of tests is specified. If is assumed that the probability of correctly selecting the better population is specified to be better than P[sup *] when the difference in success probabilities exceeds a specified change[sup *]. The populations are sampled equally and it is assumed that the trial ends either when the difference in the number of successes exceeds a calculated value of s, or when N tests have been made, whichever is sooner. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROBABILITY theory
KW  - STATISTICAL hypothesis testing
KW  - SAMPLING (Statistics)
KW  - EXAMINATIONS
KW  - CORRELATION (Statistics)
KW  - STATISTICS
KW  - BINOMIAL distribution
KW  - BINOMIAL theorem
N1  - Accession Number: 4610203; Kiefer, James E. 1; Weiss, George H. 2; Affiliations: 1: Research Mathematician, Physical Sciences Laboratory, Division of Computer Research & Technology, National Institutes of Health, Bethesda, Md. 20014.; 2: Chief, Physical Sciences Laboratory, Division of Computer Research & Technology, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Dec71, Vol. 66 Issue 336, p867; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: EXAMINATIONS; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: BINOMIAL theorem; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lemberger, L.;
AU  - Axelrod, J.;
AU  - Kopin, I. J.;
T1  - Metabolism and disposition of \D/\SU/1\BS/-tetrahydrocannabinol in man
CT  - Metabolism and disposition of \D/\SU/1\BS/-tetrahydrocannabinol in man
JO  - Pharmacol. Rev.
JF  - Pharmacol. Rev.
Y1  - 1971/12/01/
VL  - 23
IS  - Dec
SP  - 371
EP  - 379
AD  - National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1157; Language: English; References: 37; Journal Coden: PAREAQ; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Ronald E. Nagata, Jr.
N2  - Radiotracer studies with intravenous \D/\SU/1\BS/-tetrahydrocannabinol (I) showed evidence of I metabolites in the plasma within 10 minutes and of persistence over 3 days. The I is metabolized to more polar products. About 40% of the radioactive forms appear in the feces over a 7-day period and about 30% in the urine of chronic marihuana users. The nonusers excrete 22% of the drug and its metabolites in the urine.
KW  - Tetrahydrocannabinol--metabolism-;
KW  - Metabolism--tetrahydrocannabinol--and disposition, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - BAKER, CARL G.
T1  - Cancer Conquest Program.
JO  - Science
JF  - Science
Y1  - 1971/12/03/
VL  - 174
IS  - 4013
M3  - Article
SP  - 980
EP  - 981
SN  - 00368075
N1  - Accession Number: 85116582; BAKER, CARL G. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 3/1971, Vol. 174 Issue 4013, p980; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PETRICCIANI, JOHN C.
AU  - HoPPS, HOPE E.
AU  - LORENZ, DOUGLAS E.
T1  - Subhuman Primate Diploid Cells: Possible Substrates for Production of Virus Vaccines.
JO  - Science
JF  - Science
Y1  - 1971/12/03/
VL  - 174
IS  - 4013
M3  - Article
SP  - 1025
EP  - 1027
SN  - 00368075
AB  - Results of a program for development of new cell lines suggest that it it possible to establish cell lines from both rhesus and African green monkeys which are comparable to diploid lines of human origin, and that these inonkey lines should be candidates for use in the production of virus vaccines. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85116607; PETRICCIANI, JOHN C. 1; HoPPS, HOPE E. 1; LORENZ, DOUGLAS E. 1; Affiliations: 1: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 3/1971, Vol. 174 Issue 4013, p1025; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Weisburger, E. K.;
T1  - Testing of new compounds for long-term toxicity
CT  - Testing of new compounds for long-term toxicity
JO  - Journal of the Society of Cosmetic Chemists (England)
JF  - Journal of the Society of Cosmetic Chemists (England)
Y1  - 1971/12/09/
VL  - 22
IS  - Dec 9
SP  - 825
EP  - 838
SN  - 00379832
AD  - Experimental Pathology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1387; Language: English; Trade Name: Tests; Generic Name: Toxicity; References: 43; Publication Type: Review; Journal Coden: JSCCA5; Section Heading: Methodology
N2  - A survey was made of methods generally employed in testing compounds for long-term toxicity or carcinogenicity. Although the long-term testing of new compounds for chronic toxicity may superficially appear to be a straightforward matter, many factors can influence the outcome of such studies. These include the species and strain of test animal, age at start of the tests, sex, vehicle and route of administration, diet, and other variables. Some materials which are used in cosmetic formulations have the capacity to inhibit or to enhance the response of animals to known carcinogens. Awareness of all these influences is neccessary in designing meaningful long-term test for toxicity.
KW  - Toxicity--tests--chronic, discussion, in animals;
KW  - Methodology--toxicity--chronic, tests, in animals;
KW  - Carcinogens--tests--methods, chronic toxicity, in animals;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MANN, DEAN L.
AU  - ROGENTINE, G. NICHOLAS
AU  - HALTERMAN, ROGER
AU  - LEVENTHAL, BRIGID
T1  - Detection of an Antigen Associated with Acute Leukemia.
JO  - Science
JF  - Science
Y1  - 1971/12/10/
VL  - 174
IS  - 4014
M3  - Article
SP  - 1136
EP  - 1137
SN  - 00368075
AB  - Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87599952; MANN, DEAN L. 1; ROGENTINE, G. NICHOLAS 1; HALTERMAN, ROGER 1; LEVENTHAL, BRIGID 1; Affiliations: 1: Immunology Branch and Leukemia Service, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/10/1971, Vol. 174 Issue 4014, p1136; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CROZIER, RUTH
T1  - Regulation of Mammalian Reproduction.
JO  - Science
JF  - Science
Y1  - 1971/12/10/
VL  - 174
IS  - 4014
M3  - Article
SP  - 1157
EP  - 1159
SN  - 00368075
N1  - Accession Number: 87599961; CROZIER, RUTH 1; Affiliations: 1: Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 12/10/1971, Vol. 174 Issue 4014, p1157; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - GODFAIND, J. M.
AU  - PUMAIN, R.
AU  - SIGGINS, G. R.
AU  - HOFFER, B. J.
AU  - BLOOM, F. E.
T1  - Cyclic Adenosine Monophosphate and Norepinephrine: Effect on Purkinje Cells in Rat Cerebellar Cortex.
JO  - Science
JF  - Science
Y1  - 1971/12/17/
VL  - 174
IS  - 4015
M3  - Article
SP  - 1257
EP  - 1259
SN  - 00368075
N1  - Accession Number: 85116658; GODFAIND, J. M. 1; PUMAIN, R. 1; SIGGINS, G. R. 2; HOFFER, B. J. 2; BLOOM, F. E. 2; Affiliations: 1: Department of Research in Anaesthesia, McGill University, Montreal, Quebec, Canada; 2: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 12/17/1971, Vol. 174 Issue 4015, p1257; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Stetten Jr., DeWitt
T1  - Projected Changes in Medical School Curriculum.
JO  - Science
JF  - Science
Y1  - 1971/12/24/
VL  - 174
IS  - 4016
M3  - Article
SP  - 1303
EP  - 1306
SN  - 00368075
N1  - Accession Number: 85159852; Stetten Jr., DeWitt 1; Affiliations: 1: Director, National Institute of General Medical Sciences, National Institutes, Health, Bethesda, Maryland 20014; Issue Info: 12/24/1971, Vol. 174 Issue 4016, p1303; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSI41LBOUM, RICHARD M.
AU  - THOA, NGUYEN B.
AU  - JOHNSON, DAVID G.
AU  - KOPIN, IRWIN J.
AU  - AXELROD, JULIUS
T1  - Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves.
JO  - Science
JF  - Science
Y1  - 1971/12/24/
VL  - 174
IS  - 4016
M3  - Article
SP  - 1349
EP  - 1351
SN  - 00368075
AB  - Dopamine-β-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves. This enzyme is released with norepinephrine when the nerves to the guinea pig vas deferens are stimulated in vitro, and the amount of enzyme discharged increases as the length of stimulation periods increases. The amount of DBH released is proportional to the amount of norepinephrine released, and the ratio of norepinephrine to DBH discharged into the incubation medium is similar to that in the soluble portion of the contents of the synaptic vesicflers om the vas deferens. These data are compatible with the release of the neurotransmitter norepinephrine and DBH from symnpathetic nerves by a process of exocytosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159876; WEINSI41LBOUM, RICHARD M. 1; THOA, NGUYEN B. 1; JOHNSON, DAVID G. 1; KOPIN, IRWIN J. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 12/24/1971, Vol. 174 Issue 4016, p1349; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodwin, F. K.;
T1  - Psychiatric side effects of levodopa in man
CT  - Psychiatric side effects of levodopa in man
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1971/12/27/
VL  - 218
IS  - Dec 27
SP  - 1915
EP  - 1920
AD  - Section on Psychiatry, Laboratory of Clinical Science, Building 10, Room 45-239, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-1809; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 65; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - The major psychiatric side effects reported in 908 parkinsonian patients treated with levodopa were confusion, delirium, depression, overactivity, psychosis, delusions, paranoia, hypomania and hypersexual behavior. Since mental side effects of levodopa therapy varied from individual to individual, it is clear that levodopa does not uniformly produce a specific set of mental changes.
KW  - Levodopa--toxicity-;
KW  - Toxicity--levodopa--side effects, psychiatric, in patients;
KW  - Antiparkinson agents--levodopa--toxicity, side effects, psychiatric, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Fauci, A. S.;
AU  - Wolff, S. M.;
AU  - Johnson, J. S.;
T1  - Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis
CT  - Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1971/12/30/
VL  - 285
IS  - Dec 30
SP  - 1493
EP  - 1496
SN  - 00284793
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, 11 South, Room 242, Bethesda, Maryland 20014
N1  - Accession Number: 9-1637; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents cyclophosphamide; References: 31; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - Nine patients with Wegener's granulomatosis were studied before and after treatment with cyclophosphamide alone, in order to determine any immunologic abnormalities associated with the disease, to observe the effect of cyclophosphamide on the clinical course, as well as on the immune response in man, and to observe any correlation between clinical response and immunosuppression. The doses of cyclophosphamide varied from 50 to 125 mg./day, and the duration of therapy varied from one to 39 months in the patients studied. This study showed that patients with generalized Wegener's granulomatosis treated with cyclophosphamide alone display suppressed humoral antibody and cellular (delayed skin reactivity) responses to an antigen with which they have had no prior immunologic experience.
KW  - Cyclophosphamide--Wegener's granulomatosis-;
KW  - Immunosuppressive agents--cyclophosphamide--Wegener's granulomatosis, therapy, in patients, effect on immune response;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Davidson, M.;
AU  - Feinleib, M.;
T1  - Carbon disulfide poisoning: a review
CT  - Carbon disulfide poisoning: a review
JO  - Am. Heart J.
JF  - Am. Heart J.
Y1  - 1972/01/01/
VL  - 83
IS  - Jan
SP  - 100
EP  - 114
AD  - Field Epidemiology Research Section, Clinical Applications Program, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-2093; Language: English; Chemical Name: Carbon disulfide--75-15-0; References: 63; Publication Type: Review; Journal Coden: AHJOA2; Section Heading: Toxicity; Abstract Author: David D. Edwards
N2  - A review of carbon disulfide (CS\IF/2\BS/), as a possible industrial hazard, is presented.
KW  - Carbon disulfide--toxicity, environmental-;
KW  - Toxicity, environmental--carbon disulfide--review, possible industrial hazard;
KW  - Poisoning--carbon disulfide--effects, acute and chronic toxicity, in man, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Law, N. C.;
AU  - Fales, H. M.;
AU  - Milne, G. W. A.;
T1  - Identification of drugs taken in overdose cases
CT  - Identification of drugs taken in overdose cases
JO  - Clin. Toxicol.
JF  - Clin. Toxicol.
Y1  - 1972/01/01/
VL  - 5
IS  - Jan
SP  - 17
EP  - 21
AD  - Suburban Hospital and Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-0327; Language: English; References: 2; Journal Coden: CTOXAO; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2  - Mass spectrometry was used to identify drug products in gastric contents, serum, urine, and gastric lavage fluids. Gastric contents were the most promising source of large quantities of unchanged drugs. If these were not available, the first gastric lavage fluids proved most useful. Drug metabolites in the urine and serum can produce confusing data; however, positive drug identification can be made.
KW  - Spectrometry, mass--toxicology--drugs, identification in overdose cases;
KW  - Poisoning--drugs--identification, mass spectrometry;
KW  - Toxicity--drugs--overdosage, identification of drugs by mass spectrometry;
KW  - Metabolism--drugs--body distribution, identification, in overdose cases, mass spectrometry;
KW  - Drugs, body distribution--poisoning--identification, in overdose cases, mass spectrometry;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Shrager, Richard I.
AU  - Timlake, W. P.
T1  - Quadratic Programming for Nonlinear Regression.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1972/01//
VL  - 15
IS  - 1
M3  - Article
SP  - 41
EP  - 46
SN  - 00010782
AB  - A quadratic programming algorithm is described for use with the magnified diagonal method of nonlinear regression with linear constraints. The regression method is published in JACM, July 1970. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - QUADRATIC programming
KW  - ALGORITHMS
KW  - REGRESSION analysis
KW  - NONLINEAR programming
KW  - MATHEMATICAL statistics
KW  - MATHEMATICAL programming
KW  - constraints
KW  - inequality
KW  - iteration
KW  - least squares
KW  - nonlinear equations
KW  - nonlinear programming
KW  - nonlinear regression
KW  - quadratic programming
N1  - Accession Number: 5221620; Shrager, Richard I. 1 Timlake, W. P.; Affiliation:  1: Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, MA 20014.; Source Info: Jan1972, Vol. 15 Issue 1, p41; Subject Term: QUADRATIC programming; Subject Term: ALGORITHMS; Subject Term: REGRESSION analysis; Subject Term: NONLINEAR programming; Subject Term: MATHEMATICAL statistics; Subject Term: MATHEMATICAL programming; Author-Supplied Keyword: constraints; Author-Supplied Keyword: inequality; Author-Supplied Keyword: iteration; Author-Supplied Keyword: least squares; Author-Supplied Keyword: nonlinear equations; Author-Supplied Keyword: nonlinear programming; Author-Supplied Keyword: nonlinear regression; Author-Supplied Keyword: quadratic programming; Number of Pages: 6p; Illustrations: 1 Graph; Document Type: Article
L3  - 10.1145/361237.361248
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Raub, William F
T1  - Automated information-handling in pharmacology research
JO  - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 1157-1165. 11 Illus. 8 Ref. See Isa 72-3078/y
JF  - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 1157-1165. 11 Illus. 8 Ref. See Isa 72-3078/y
Y1  - 1972///
M3  - Book Chapter
N1  - Accession Number: ISTA0703249; Raub, William F 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1972; Note: Update Code: 0700; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Jones, Thomas L
T1  - A computer model of simple forms of learning in infants
JO  - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 885-895. 15 Illus. 18 Ref. See Isa 72-3078/y
JF  - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 885-895. 15 Illus. 18 Ref. See Isa 72-3078/y
Y1  - 1972///
M3  - Book Chapter
N1  - Accession Number: ISTA0703201; Jones, Thomas L 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1972; Note: Update Code: 0700; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Wright, L. J.;
AU  - Lipsett, M. B.;
AU  - Ross, G. T.;
AU  - Wolff, S. M.;
T1  - Effects of dexamethasone and aspirin on the responses to endotoxin in man
CT  - Effects of dexamethasone and aspirin on the responses to endotoxin in man
JO  - J. Clin. Endocrinol. Metab.
JF  - J. Clin. Endocrinol. Metab.
Y1  - 1972/01/01/
VL  - 34
IS  - Jan
SP  - 13
EP  - 17
AD  - National Institutes of Health, Building 10, Room 11N-232, Bethesda, Maryland 20014
N1  - Accession Number: 11-0526; Language: English; Chemical Name: Dexamethasone--50-02-2 Aspirin--50-78-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- dexamethasone; References: 18; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The effects of aspirin and dexamethasone on the fever, clinical symptoms, granulocyte response, plasma cortisol and growth hormone levels produced by bacterial endotoxin were investigated. Dexamethasone, and to a lesser extent aspirin, suppressed much of the fever and undesirable symptoms. Granulocyte response was enhanced by dexamethasone but was unchanged by aspirin. The increase in plasma cortisol levels was unaffected by these antipyretic agents, although dexamethasone diminished the number of positive growth hormone responses to endotoxin. There was no correlation between fever and either plasma cortisol or growth hormone response.
KW  - Dexamethasone--fever-;
KW  - Aspirin--fever-;
KW  - Steroids, cortico---dexamethasone--effects, bacterial endotoxin fever, in patients;
KW  - Fever--endotoxins--bacterial, effects, aspirin or dexamethasone, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Heller, Stephen R
AU  - Koniver, Deena A
T1  - Computer generation of wiswesser line notation
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1972///
VL  - 12
IS  - 1
M3  - Article
SP  - 56
EP  - 59
SN  - 00219576
AB  - The computer program for the generation of wiswesser line notation (wln) has been extended to include polyfused rings, methly contraction rules, chain of two ring systems, some perifused rings, some chelates, and some metallocenes. Salts and ions are also handled, but in a different manner than what is normally found. Multipliers are not used by the program. The normal input for the wln generation is an easy input program using a rand tablet; however, teletype and connection table input can also used in most cases.
N1  - Accession Number: ISTA0701458; Heller, Stephen R 1; Koniver, Deena A; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1972, Vol. 12 Issue 1, p56; Note: Update Code: 0700; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Donnelly, Edward F.
AU  - Dent, James K.
AU  - Murphy, Dennis L.
AU  - Mignone, Robert J.
T1  - COMPARISON OF TEMPORAL LOBE EPILEPTICS AND AFFECTIVE DISORDERS ON THE HALSTEAD-REITAN TEST BATTERY.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1972/01//
VL  - 28
IS  - 1
M3  - Article
SP  - 61
EP  - 62
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article presents a study wherein "brain damage" is defined as recorded EEG abnormalities in temporal lobe epileptics and "without brain damage" is defined as affective disorders with no neurological deficits. Thus, the study explores the apparent implications of the degree of impairment in serious psychological disorders. Since temporal lobe epileptics generally show less neuropathology than other types of brain damage and since most subjects with affective disorders were diagnosed psychotic, expectation would favor a similar degree of impairment in both diagnostic groups.
KW  - CEREBROVASCULAR disease
KW  - BRAIN damage
KW  - AFFECTIVE disorders
KW  - PATHOLOGICAL psychology
KW  - NEUROLOGY
KW  - ELECTROENCEPHALOGRAPHY
N1  - Accession Number: 15847437; Donnelly, Edward F. 1 Dent, James K. 1 Murphy, Dennis L. 1 Mignone, Robert J. 2; Affiliation:  1: National Institute of Mental Health, Bethesda, Maryland.  2: National Institute of Neurological Diseases and Stroke, Bethesda, Maryland.; Source Info: Jan1972, Vol. 28 Issue 1, p61; Subject Term: CEREBROVASCULAR disease; Subject Term: BRAIN damage; Subject Term: AFFECTIVE disorders; Subject Term: PATHOLOGICAL psychology; Subject Term: NEUROLOGY; Subject Term: ELECTROENCEPHALOGRAPHY; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Archard, Howell O.
AU  - Tarpley, Jr., Thomas M.
T1  - Clinicopathologic and histochemical characterization of submucosal deposits in snuff dipper's keratosis.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1972/01//
VL  - 1
IS  - 1
M3  - Article
SP  - 3
EP  - 11
SN  - 03009777
AB  - The article reports on the clinicopathologic correlation and histochemical characterization of submucosal deposits from three patients with snuff dipper's keratosis. Each patient underwent a thorough oral examination, and a complete history was obtained concerning the kind of snuff used, the frequency and duration of application, and other tobacco habits. A biopsy of the clinical white lesion was then obtained taking care to include submucosa and associated glandular elements. The findings indicates the staining characteristics of the submucosal deposits in the three cases of snuff dipper's keratosis.
KW  - SNUFF
KW  - PATIENTS
KW  - BIOPSY
KW  - DIAGNOSIS
KW  - KERATOSIS
KW  - SMOKELESS tobacco
N1  - Accession Number: 14879377; Archard, Howell O. 1 Tarpley, Jr., Thomas M. 1; Affiliation:  1: Section of Diagnostic Pathology, Laboratory of Experimental Pathology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.; Source Info: 1972, Vol. 1 Issue 1, p3; Subject Term: SNUFF; Subject Term: PATIENTS; Subject Term: BIOPSY; Subject Term: DIAGNOSIS; Subject Term: KERATOSIS; Subject Term: SMOKELESS tobacco; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1600-0714.ep14879377
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Perrine, T. D.;
AU  - Atwell, L.;
AU  - Tice, I. B.;
AU  - Jacobson, A. E.;
AU  - May, E. L.;
T1  - Analgesic activity as determined by the Nilsen Method
CT  - Analgesic activity as determined by the Nilsen Method
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1972/01/01/
VL  - 61
IS  - Jan
SP  - 86
EP  - 88
SN  - 00223549
AD  - Laboratory of Chemistry and Biomedical Engineering and Instrument Branch, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-4839; Language: English; References: 14; Journal Coden: JPMSAE; Section Heading: Methodology
N2  - The Nilsen method for determining analgesic activity (pain stimulus and electrical pulsations to the mouse tail) was compared with the hotplate procedure for several compounds including ""pure'' analgesics, i.e. agonists (morphine, codeine, and meperidine), a known ""pure'' antagonist (naloxone), several so-called mixed agonist-antagonists (nalorphine, pentazocine, and cyclazocine), one antagonist that appears to be naloxonelike, and 2 compounds of relatively unknown pharmacology. The results obtained confirm the validity of the Nilsen test for the agonists and indicate its superior predictive value (to the hotplate, Smith D'Amour, and perhaps writhing methods) for man with those substances possessing antagonist properties. Refinements in methodology and instrumentation are described. Illustrations and photographs are included.
KW  - Methodology--analgesics--screening, Nilsen method, evaluation;
KW  - Equipment--analgesics--screening, Nilsen method, evaluation;
KW  - Analgesics and antipyretics--methodology--screening, Nilsen method, evaluation;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Epstein, E. H.;
AU  - Levin, D. L.;
AU  - Croft, J. D.;
AU  - Lutzner, M. A.;
T1  - Mycosis fungoides
CT  - Mycosis fungoides
JO  - Medicine (Baltimore)
JF  - Medicine (Baltimore)
Y1  - 1972/01/01/
VL  - 15
IS  - Jan
SP  - 61
EP  - 72
AD  - National Institutes of Health, Room 12 N238, Building 10, Bethesda, Maryland 20014
N1  - Accession Number: 9-2619; Language: English; References: 27; Journal Coden: MEDIAV; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Richard A. Hutchinson
N2  - This article summarizes the clinical course and pathological findings of 144 patients with mycosis fungoides at NIH. All mycosis fungoides patients studied between 1954-1969 by NIH are summarized as to onset, first clinical signs, pathological findings, survival and prognosis, and response to therapy. During the 15 years of the study, over 30 types of therapy were used. The summary includes the most common forms and their effects on patients' prognoses.
KW  - Mycosis fungoides--in humans--clinical course, pathological findings, and response to therapy;
KW  - Fungicides--mycosis fungoides--in humans, clinical course, pathological findings, and response to therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Wyatt, H V
T1  - When does information become knowledge?
JO  - Nature 235(5333), 86-89 (1972 January 14). 1 Illus. 1 Tab. 38 Ref
JF  - Nature 235(5333), 86-89 (1972 January 14). 1 Illus. 1 Tab. 38 Ref
Y1  - 1972///
M3  - Book Chapter
AB  - By considering a specific example from molecular biology, the author examines the factors that determine the transformation of scientific information into knowledge. He concludes that new information can be assimilated only when it can be fitted without too much difficulty into accepted ideas. As information it is unrecogized until it is transformed into knowledge.
N1  - Accession Number: ISTA0701803; Wyatt, H V 1; Affiliations: 1 : National Cancer Institute, National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1972; Note: Update Code: 0700; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 
TY  - JOUR
AU  - Lystad, Mary Hanemann
T1  - Social Alienation: A Review of Current Literature.
JO  - Sociological Quarterly
JF  - Sociological Quarterly
Y1  - 1972///Winter72
VL  - 13
IS  - 1
M3  - Article
SP  - 90
EP  - 113
SN  - 00380253
AB  - In recent years considerable attention has been focused on delineation of the concept of alienation and on measurement of its relationship to modern social structure and function. This paper reviews the alienation literature, largely empirically oriented, for the last decade. Included with works of primarily theoretical and methodological importance are substantive studies of the relationships between the alienated individual and his social order. Suggestions for further research are given. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Sociological Quarterly is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALIENATION (Social psychology)
KW  - SOCIAL structure
KW  - FORMAL sociology
KW  - SOCIAL systems
KW  - SCIENTIFIC literature
KW  - EMPIRICISM
KW  - SOCIAL order
KW  - SOCIAL conflict
N1  - Accession Number: 14009832; Lystad, Mary Hanemann 1; Affiliation:  1: National Institute of Mental Health; Source Info: Winter72, Vol. 13 Issue 1, p90; Subject Term: ALIENATION (Social psychology); Subject Term: SOCIAL structure; Subject Term: FORMAL sociology; Subject Term: SOCIAL systems; Subject Term: SCIENTIFIC literature; Subject Term: EMPIRICISM; Subject Term: SOCIAL order; Subject Term: SOCIAL conflict; Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-40851-004
AN  - 2013-40851-004
AU  - Bell, Richard Q.
AU  - Waldrop, Mary F.
AU  - Weller, George M.
T1  - A rating system for the assessment of hyperactive and withdrawn children in preschool samples.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1972/01//
VL  - 42
IS  - 1
SP  - 23
EP  - 34
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Bell, Richard Q., Child Research Branch, National Institute of Mental Health, Building 15K, 9000 Rockville Pike, 200, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-40851-004. PMID: 5013504 Partial author list: First Author & Affiliation: Bell, Richard Q.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Audits; Preschool Teachers. Classification: Educational Psychology (3500). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jan, 1972. 
AB  - Six aspects of hyperactivity and three of withdrawal can be rated by preschool teachers on a weekly basis and quickly converted into two factor scores to keep a running account of the status of children in a group. Applications of the system could include clinical studies of response to treatment, and separate identification of children unlikely to respond to group enrichment programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical studies
KW  - preschool teachers
KW  - withdrawn children
KW  - group enrichment programs
KW  - 1972
KW  - Clinical Audits
KW  - Preschool Teachers
KW  - 1972
DO  - 10.1111/j.1939-0025.1972.tb02467.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1972-26679-001
AN  - 1972-26679-001
AU  - Perez-Cruet, J.
AU  - Tagliamonte, A.
AU  - Tagliamonte, P.
AU  - Gessa, G. L.
T1  - Changes in brain serotonin metabolism associated with fasting and satiation in rats.
JF  - Life Sciences
JO  - Life Sciences
JA  - Life Sci
Y1  - 1972/01//
VL  - 11
IS  - 1, Pt. 2
SP  - 31
EP  - 39
CY  - Netherlands
PB  - Elsevier Science
SN  - 0024-3205
N1  - Accession Number: 1972-26679-001. Partial author list: First Author & Affiliation: Perez-Cruet, J.; National Institutes of Health, Lab. of Chemical Pharmacology, Bethesda, Md. Release Date: 19721001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Food Intake; Metabolism. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 9. Issue Publication Date: Jan, 1972. 
AB  - Rats fasted for 24 hr. were fed for 2 hr., after which time food was removed. Food intake decreased brain 5-hydroxyindole acetic acid and tryptophan levels by about 22% and 27%, respectively, but did not modify brain serotonin concentration. These changes persisted for about 6 hr. The synthesis rate of brain serotonin was about 30% lower in Ss fed for 2 hr. than in Ss fasted for 24 hr. Food intake produced changes in plasma tryptophan opposite to those produced in brain. Feeding also decreased brain serotonin turnover in hypophysectomized Ss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain serotonin metabolism
KW  - fasting vs. satiation
KW  - rat
KW  - 1972
KW  - Brain
KW  - Food Intake
KW  - Metabolism
KW  - Rats
KW  - 1972
DO  - 10.1016/0024-3205(72)90149-X
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40851-009
AN  - 2013-40851-009
AU  - Torrey, E. Fuller
T1  - What Western psychotherapists can learn from witchdoctors.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1972/01//
VL  - 42
IS  - 1
SP  - 69
EP  - 76
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Torrey, E. Fuller, National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20852
N1  - Accession Number: 2013-40851-009. PMID: 5013510 Partial author list: First Author & Affiliation: Torrey, E. Fuller; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1971, Washington, DC, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Ethnocentrism; Expectations; Physicians; Psychotherapists. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 8. Issue Publication Date: Jan, 1972. 
AB  - Western psychotherapists have been remarkably ethnocentric in their view of themselves. They have failed to learn from their counterparts in other cultures, the witchdoctors. This paper reviews some of the things they can learn, namely the importance of 1) the Principle of Rumpelstiltskin, 2) the personal qualities of the therapist, 3) the patients' expectations, and 4) the techniques of therapy. It is concluded that we have much to learn from witchdoctors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Western psychotherapists
KW  - witchdoctors
KW  - ethnocentrics
KW  - cultures
KW  - patients expectations
KW  - 1972
KW  - Ethnocentrism
KW  - Expectations
KW  - Physicians
KW  - Psychotherapists
KW  - 1972
DO  - 10.1111/j.1939-0025.1972.tb02472.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-40851-011
AN  - 2013-40851-011
AU  - Symmes, Jean S.
AU  - Rapoport, Judith L.
T1  - Unexpected reading failure.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1972/01//
VL  - 42
IS  - 1
SP  - 82
EP  - 91
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Symmes, Jean S., National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-40851-011. PMID: 5013512 Partial author list: First Author & Affiliation: Symmes, Jean S.; National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20160915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1971, Washington, DC, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Imagery; Learning Disabilities; Reading; Spatial Ability. Minor Descriptor: Patient History. Classification: Learning Disorders (3253). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Wide Range Achievement Test DOI: 10.1037/t49277-000; Wechsler Intelligence Scale for Children. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan, 1972. 
AB  - Eliminating children with any condition in medical history or present status that might indicate a predisposition to learning problems, the remaining population of 54 contained only one girl and was characterized by superiority in certain visual skills. A genetic linkage between spatial visualization and difficulty in acquiring reading skills is postulated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - learning problems
KW  - medical history
KW  - spatial visualization
KW  - visual skills
KW  - 1972
KW  - Imagery
KW  - Learning Disabilities
KW  - Reading
KW  - Spatial Ability
KW  - Patient History
KW  - 1972
DO  - 10.1111/j.1939-0025.1972.tb02474.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - BOOK
ID  - 2007-19564-000
AN  - 2007-19564-000
AU  - Maddi, Salvatore R.
AU  - Costa, Paul T.
T1  - Humanism in personology: Allport, Maslow, and Murray.
Y1  - 1972///
CY  - Piscataway, NJ, US
PB  - Transaction Publishers
SN  - 0-202-36173-X
SN  - 978-0-202-36173-4
N1  - Accession Number: 2007-19564-000. Partial author list: First Author & Affiliation: Maddi, Salvatore R.; Department of Psychology and Social Behavior, School of Social Ecology, University of California, Irvine, CA, US. Reprinted: 2008. Release Date: 20080331. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. ISBN: 0-202-36173-X, Paperback; 978-0-202-36173-4, Paperback. Language: English. Major Descriptor: Humanism; Humanistic Psychology; Maslow (Abraham Harold); Personality; Psychologists. Minor Descriptor: Psychological Theories. Classification: Personality Psychology (3100). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 200. 
AB  - Through analysis of the lives and theories of the three major exponents of humanism, Allport, Maslow, and Murray, the authors have marshaled some compelling arguments for an alternative to the extreme behaviorism of Skinner and the logical positivism of Freud. This work is a concise, clear synthesis of both broad theoretical positions and specific concepts that underlie humanistic psychology. The 'Third Force' (humanism) suggests that man possesses both freedom and dignity and that he possesses them in the face of an often hostile and coercive society. Thus, exponents of humanism conducted their personality experiments in a natural environment, imposing few, if any, external controls. A compact example of critical evaluation at its best, Humanism in Personology stands alone in its successful attempt to correlate the theory of humanism as it exists today with an incisive study of the men who shaped its course. Maddi and Costa proceed from the level of metatheory to a lucid presentation of the specific constructs of three personality psychologists. The book contains an extensive theoretical summary table explaining the theoretical differences between Allport, Maslow, and Murray. Also featured is a comprehensive glossary of personality terms, which is exceedingly valuable for new students in the field. Intended as a supplementary text for undergraduate courses in personality, social psychology, human development, human socialization, or philosophy, this work is also a valuable resource for clinicians, teachers, guidance counselors, graduates, and undergraduates in psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - humanism
KW  - personology
KW  - Allport
KW  - Maslow
KW  - Murray
KW  - theories
KW  - humanistic psychology
KW  - Third Force
KW  - personality
KW  - 1972
KW  - Humanism
KW  - Humanistic Psychology
KW  - Maslow (Abraham Harold)
KW  - Personality
KW  - Psychologists
KW  - Psychological Theories
KW  - 1972
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Warmolts, J. R.;
AU  - Engel, W. K.;
T1  - Benefit from alternate-day prednisone in myasthenia gravis
CT  - Benefit from alternate-day prednisone in myasthenia gravis
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/01/06/
VL  - 286
IS  - Jan 6
SP  - 17
EP  - 20
SN  - 00284793
AD  - Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014
N1  - Accession Number: 9-1867; Language: English; Chemical Name: Prednisone--53-03-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Five adults with myasthenia gravis of varying severity and duration were treated with long-term, high single dosage (100 mg.), alternate-day oral prednisone. Improvement in muscle function appeared 24 to 72 hours after the initiation of therapy and has been maintained from 6 to 17 months. Complete remission of symptoms was obtained in one patient in 4 months and has been maintained for 13 months.
KW  - Prednisone--myasthenia gravis-;
KW  - Steroids, cortico---prednisone--myasthenia gravis, therapy, high dose, in patients;
KW  - Dosage--prednisone--high, myasthenia gravis, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MOSS, W. GLEN
T1  - Approval of Research Grants.
JO  - Science
JF  - Science
Y1  - 1972/01/07/
VL  - 175
IS  - 4017
M3  - Article
SP  - 10
EP  - 10
SN  - 00368075
N1  - Accession Number: 85159885; MOSS, W. GLEN 1; Affiliations: 1: National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/ 7/1972, Vol. 175 Issue 4017, p10; Number of Pages: 1/5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DANTE, M. L.
AU  - CHRAMBACH, A.
T1  - Buffer Systems and PAGE.
JO  - Science
JF  - Science
Y1  - 1972/01/07/
VL  - 175
IS  - 4017
M3  - Article
SP  - 95
EP  - 95
SN  - 00368075
N1  - Accession Number: 85159926; DANTE, M. L. 1; CHRAMBACH, A. 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; 2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/ 7/1972, Vol. 175 Issue 4017, p95; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VAN BOXEL, JOHN A.
AU  - STOBO, JOHN D.
AU  - PAUL, WILLIAM E.
AU  - GREEN, IRA
T1  - Antibody-Dependent Lymphoid Cell—Mediated Cytotoxicity: No Requirement for Thymus-Derived Lymphocytes.
JO  - Science
JF  - Science
Y1  - 1972/01/14/
VL  - 175
IS  - 4018
M3  - Article
SP  - 194
EP  - 196
SN  - 00368075
AB  - The capacity of lymphoid cells from nonsensitized mice to lyse antibody-coated target erythrocytes in vitro does not require the presence of thymus-derived or thymus-dependent lymphocytes. Thus, spleen cells from thymus-deprived mice and spleen cell populations from which thymus-dependent lymphocytes had been removed were fully competent to mediate destruction of antibody-coated target cells. However, prior treatment of spleen cell populations with antibody to K chains diminished this function, suggesting a role for bone marrow-derived lymphocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87423331; VAN BOXEL, JOHN A. 1; STOBO, JOHN D. 1; PAUL, WILLIAM E. 1; GREEN, IRA 1; Affiliations: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p194; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - STEWART, SARAH E.
AU  - KASNIC JR., GEORGE
AU  - DRAYCOTT, CATHERINE
AU  - BEN, THERESA
T1  - Activation of Viruses in Human Tumors by 5-Iododeoxyuridine and Dimethyl Sulfoxide.
JO  - Science
JF  - Science
Y1  - 1972/01/14/
VL  - 175
IS  - 4018
M3  - Article
SP  - 198
EP  - 199
SN  - 00368075
AB  - Dimethyl sulfoxide added to cultures first treated with 5-iododeoxyuridine increased C-type virus production approximately tenfold in a human rhabdomyosarcoma cell line. 5-Iododeoxyuridine followed by dimethyl sulfoxide also activated a similar C-type virus in a metastatic tumor from a bronchial node taken from a 52-year-old male. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87423333; STEWART, SARAH E. 1; KASNIC JR., GEORGE 1; DRAYCOTT, CATHERINE 1; BEN, THERESA 2; Affiliations: 1: School of Medicine, Georgetown University, Washington, D.C. 20007; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p198; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WOLLBERG, ZVI
AU  - NEWMAN, JOHN D.
T1  - Auditory Cortex of Squirrel Monkey: Response Patterns of Single Cells to Species-Specific Vocalizations.
JO  - Science
JF  - Science
Y1  - 1972/01/14/
VL  - 175
IS  - 4018
M3  - Article
SP  - 212
EP  - 214
SN  - 00368075
AB  - Most of the neurons tested in the superior temporal cortex of awake squirrel monkeys responded to recorded species-specific vocalizations. Some cells responded with temporally complex patterns to many vocalizations. Other cells responded with simpler patterns to only one call. Most cells lay between these two extremes. On-line deletion of parts of a vocalization revealed the role of temporal interactions in determining the nature of some responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87423341; WOLLBERG, ZVI 1; NEWMAN, JOHN D. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p212; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SEVER, JOHN L.
T1  - Subacute Sclerosing Panencephalitis Treatment.
JO  - Science
JF  - Science
Y1  - 1972/01/14/
VL  - 175
IS  - 4018
M3  - Article
SP  - 220
EP  - 223
SN  - 00368075
N1  - Accession Number: 87423344; SEVER, JOHN L. 1; Affiliations: 1: National Intitute of Neurological Diseases and Stroke, National Institutes of Health Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p220; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHNEIDER, JOHN H.
T1  - Letters.
JO  - Science
JF  - Science
Y1  - 1972/01/21/
VL  - 175
IS  - 4019
M3  - Article
SP  - 256
EP  - 257
SN  - 00368075
N1  - Accession Number: 87615451; SCHNEIDER, JOHN H. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1972, Vol. 175 Issue 4019, p256; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KWON-CHUNG, K. J.
T1  - Sexual Stage of Histoplasma capsulatum.
JO  - Science
JF  - Science
Y1  - 1972/01/21/
VL  - 175
IS  - 4019
M3  - Article
SP  - 326
EP  - 326
SN  - 00368075
AB  - Twelve primary subcultures of Histoplasma capsulatum, paired in all possible combinations on agar containing yeast extract and Alphacel, produced fertile cleistothecia, resembling those of Ajellomyces dermatitidis (Blastomyces dermatitidis). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87615479; KWON-CHUNG, K. J. 1; Affiliations: 1: Laboratory of Microbiology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1972, Vol. 175 Issue 4019, p326; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Johnson, Donald W.
AU  - Bernstein, Stuart
T1  - Classification of States Regarding Expanding Duties for Dental Auxiliaries and Selected Aspects of Dental Licensure -- 1970.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/02//
VL  - 62
IS  - 2
M3  - Article
SP  - 208
EP  - 215
PB  - American Public Health Association
SN  - 00900036
AB  - A discussion is presented of the expanded functions of dental auxiliaries and the recognition of this development in terms of licensure. Further revision of dental practice acts is urged to meet the increasing demand for dental care. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Group dental practice
KW  - Dental insurance
KW  - Dental care
KW  - Medical care
KW  - Dental health maintenance organizations
KW  - Dentistry
KW  - Dentists
KW  - Community dental services
KW  - United States
N1  - Accession Number: 24294018; Johnson, Donald W. 1; Bernstein, Stuart 2; Affiliations: 1: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; 2: Division of Manpower Intelligence, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; Issue Info: Feb1972, Vol. 62 Issue 2, p208; Subject Term: Group dental practice; Subject Term: Dental insurance; Subject Term: Dental care; Subject Term: Medical care; Subject Term: Dental health maintenance organizations; Subject Term: Dentistry; Subject Term: Dentists; Subject Term: Community dental services; Subject: United States; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bagley, C. M., Jr.;
AU  - DeVita, V. T.;
AU  - Berard, C. W.;
AU  - Canellos, G. P.;
T1  - Advanced lymphosarcoma: intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone
CT  - Advanced lymphosarcoma: intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/02/01/
VL  - 76
IS  - Feb
SP  - 227
EP  - 234
SN  - 00034819
AD  - Building 10, Room 12N226, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-0579; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Vincristine--57-22-7 Prednisone--53-03-2; References: 29; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Thirty-five patients with advanced lymphosarcoma (32 without previous therapy) were treated with intensive 5-day courses of cyclophosphamide and prednisone, with vincristine given on the first day; this was repeated every 3 weeks until complete remission was attained or tumor resistance appeared. The dosages were as follows: cyclophosphamide, 400 mg./m\SU/2\BS/, orally; vincristine, 1.4 mg./m\SU/2\BS/, I.V. on the first day, and; prednisone 100 mg./m\SU/2\BS/ orally. Therapy was discontinued from days 6 through 21, then repeated. There were 20 complete and 12 partial responses. Of the complete remissions 89% lasted more than one year. Of all 35 patients, 79% lived more than one year. Survival of complete responders was significantly better than that of partial responders. Patients with more extensive disease had significantly shorter survival. Toxicity, chiefly leukopenia, was tolerable, reversible, and not cumulative. In inducing frequent and long-lasting complete remissions, this regimen appears superior to those previously reported.
KW  - Cyclophosphamide--vincristine and prednisone-;
KW  - Vincristine--cyclophosphamide and prednisone-;
KW  - Prednisone--cyclophosphamide and vincristine-;
KW  - Combined therapy--cyclophosphamide and prednisone and vincristine--lymphosarcoma, advanced, therapy, in patients;
KW  - Antineoplastic agents--combined therapy--lymphosarcoma, advanced, in patients;
KW  - Combined therapy--vincristine, cyclophosphamide and prednisone--lymphosarcoma, advanced, in patients;
KW  - Combined therapy--prednisone, cyclophosphamide and vincristine--lymphosarcoma, advanced, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Anderson, L. G.
AU  - Talal, N.
T1  - THE SPECTRUM OF BENIGN TO MALIGNANT LYMPHOPROLIFERATION IN SJÖGREN'S SYNDROME.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1972/02//
VL  - 10
IS  - 2
M3  - Article
SP  - 199
EP  - 221
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Clinical and pathological evidence suggests that a wide spectrum of lymphoproliferation exists in Sjögren's syndrome (SS), from benign disease with lymphoid infiltrates confined to glandular tissue on the one end, to widespread lymphoreticular malignancy on the other. In the middle of the spectrum are patients threatened by extraglandular extension of lymphoproliferation which is not clinically or histologically malignant and which apparently has the potential to regress with appropriate therapy or to progress to frank neoplasia. Illustrative patients are described. Over thirty other case reports associating 55 with pseudolymphoma, Waldenstrorn's macroglobulinaemia, reticulum cell sarcoma, or other lymphomas appear in the literature, Similar lymphoproliferative processes have been observed in other autoimmune diseases, in certain immune deficiency states, with hydantoin and other anticonvulsant drugs, and in experimental animal models. In SS, as in these other conthtions, it seems likely that a combination of genetic, immunologic, and viral or other unknown environmental factors plays a role in pathogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOPROLIFERATIVE disorders
KW  - IMMUNOLOGIC diseases
KW  - AUTOIMMUNE diseases
KW  - LYMPHOMAS
KW  - DISEASES
KW  - LABORATORY animals
N1  - Accession Number: 14545352; Anderson, L. G. 1 Talal, N. 1; Affiliation:  1: National Institute of Dental Research and National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Feb72, Vol. 10 Issue 2, p199; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: IMMUNOLOGIC diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: LYMPHOMAS; Subject Term: DISEASES; Subject Term: LABORATORY animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 23p; Document Type: Article
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DB  - aph
ER  - 

TY  - GEN
AU  - Feldmann, Richard J
AU  - Heller, Stephen R
AU  - Shapiro, Kenneth P
T1  - An application of interactive computing-a chemical information system
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1972/02//
VL  - 12
IS  - 1
M3  - Article
SP  - 41
EP  - 47
SN  - 00219576
AB  - A collection of computer programs to do chemical information retrieval are described in terms of the interactions between the computer and the chemist. The medium of interaction is the language of the chemist-the structural diagram. In interacting with the computer, the chemist can graphically specify two-dimensional structures as queries and view structures as search results.
N1  - Accession Number: ISTA0701490; Feldmann, Richard J 1; Heller, Stephen R; Shapiro, Kenneth P; Affiliations: 1 : National Institutes Of Health, Bethesda,maryland.;  Source Info: February 1972, Vol. 12 Issue 1, p41; Note: Update Code: 0700; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Miller, George A
T1  - Encoding and decoding wln
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1972/02//
VL  - 12
IS  - 1
M3  - Article
SP  - 60
EP  - 67
SN  - 00219576
AB  - This paper deals with the encoding and decoding of a wiswesser line national (wln). This problem so far has been addressed only from the point of a human. This paper discusses the encoding and decoding with exactness suitable for a computer, and is an outgrowth of a computer program now in operation at nih which automatically encodes and decodes wln.
N1  - Accession Number: ISTA0701460; Miller, George A 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: February 1972, Vol. 12 Issue 1, p60; Note: Update Code: 0700; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - McCallin, P. F.;
AU  - Fuccillo, D. A.;
AU  - Lay, A. C.;
AU  - Gilkeson, M. R.;
AU  - Traub, R. E.;
AU  - \ET/;
T1  - Gamma globulin as prophylaxis against rubella-induced congenital anomalies
CT  - Gamma globulin as prophylaxis against rubella-induced congenital anomalies
JO  - Obstetrics and Gynecology (USA)
JF  - Obstetrics and Gynecology (USA)
Y1  - 1972/02/01/
VL  - 39
IS  - Feb
SP  - 185
EP  - 189
SN  - 00297844
AD  - Department of Obstetrics and Gynecology, Hawaii Permanente Medical Group, Honolulu, Hawaii) (Reprints: c/o J. L. Sever, MD, National Institute of Nurological Diseases and Stroke, Bldg. 36, Rm. 5D04, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-4422; Language: English; References: 8; Journal Coden: OBGNAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Thomas R. Simpson
N2  - Between September, 1964 and September, 1965, 83 women who reported exposure to rubella during the first 8 weeks of pregnancy were given 20 ml. of gamma globulin. Two types were used, one having a high titer of rubella antibody (HI titer 512), and the other a low titer (HI titer 64). Of these 83 patients, 41 were found to be susceptible to rubella, 5 had seroconversions, none developed clinical rubella and none of the infants had congenital rubella. Among 13 other women who were exposed but did not receive gamma globulin, 6 were susceptible and one had a seroconversion. Another group of 949 gravidas reported no exposure during the first trimester. Of these women, 325 were susceptible, 22 has seroconversions, 10 had clinical disease and one child had congenital rubella. There was no clear-cut evidence that the incidence of seroconversion was reduced by the use of either gamma globulin preparation.
KW  - Globulins--immune serum--effects, prophylaxis against rubella-induced congenital anomalies, in women;
KW  - Rubella--toxicity--prophylaxis, against congenital anomalies, use of gamma globulin, in women;
KW  - Teratogenicity--rubella--prophylaxis, use of gamma globulin, in women;
KW  - Serums--globulins--immune serum, prophylaxis against rubella-induced congenital anomalies, in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kennedy Jr., Thomas J.
AU  - Sherman, John F.
AU  - Lamont-Havers, R. W.
T1  - Factors Contributing to Current Distress in the Academic Community.
JO  - Science
JF  - Science
Y1  - 1972/02/11/
VL  - 175
IS  - 4022
M3  - Article
SP  - 599
EP  - 607
SN  - 00368075
N1  - Accession Number: 85116756; Kennedy Jr., Thomas J. 1; Sherman, John F. 1; Lamont-Havers, R. W. 1; Affiliations: 1: Training, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/11/1972, Vol. 175 Issue 4022, p599; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SACHS, DAVID H.
AU  - PAINTER, ELIZABETH
T1  - Improved Flow Rates with Porous Sephadex Gels.
JO  - Science
JF  - Science
Y1  - 1972/02/18/
VL  - 175
IS  - 4023
M3  - Article
SP  - 781
EP  - 782
SN  - 00368075
AB  - The use of an internal support of siliconized glass beads 6 millimeters in diameter was found to improve markedly the flow rates obtainable with porous Sephadex gels without significant alteration of other properties of the gels. The method may be generally applicable in situations where rapid separations on Sephadex are required. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159973; SACHS, DAVID H. 1; PAINTER, ELIZABETH 2; Affiliations: 1: Laboratory of Chemical Biology, National Institute of Arthritis anid Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Trans plantation U.nit, General Surgical Services, Massachusetts General Hoospital, Bostoun 02114; Issue Info: 2/18/1972, Vol. 175 Issue 4023, p781; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Catalona, W. J.;
AU  - Taylor, P. T.;
AU  - Rabson, A. S.;
AU  - Chretien, P. B.;
T1  - Method for dinitrochlorobenzene contact sensitization: a clinicopathological study
CT  - Method for dinitrochlorobenzene contact sensitization: a clinicopathological study
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/02/24/
VL  - 286
IS  - Feb 24
SP  - 399
EP  - 402
SN  - 00284793
AD  - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-2297; Language: English; Chemical Name: Dinitrochlorobenzene--25567-67-3; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Methodology
N2  - To facilitate measurement of cell mediated immune responses, a method for quantitative clinical evaluation of contact sensitization to dinitrochlorobenzene (DNCB) was devised and used in 40 patients with cancer. When a sensitizing dose is applied, the immediate reaction produced expresses a general inflammatory response. Sensitization is expressed by the occurrence of a spontaneous flare 7 to 14 days later, or by the reaction to a challenge dose of DNCB. Use of a sensitizing dose of 2000 mcg. and a relatively weak challenge dose of 50 mcg. yielded a satisfactory incidence of sensitization with a low proportion of irritative inflammatory reactions.
KW  - Dinitrochlorobenzene--sensitivity-;
KW  - Tests--skin--dinitrochlorobenzene, sensitivity, measurement of cell mediated immune responses, in cancer patients;
KW  - Methodology--dinitrochlorobenzene--sensitivity, tests, skin, measurement of cell mediated immune responses, in cancer patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hill, D. A.;
AU  - Baron, S.;
AU  - Perkins, J. C.;
AU  - Worthington, M.;
AU  - Van Kirk, J. E.;
AU  - \ET/;
T1  - Evaluation of an interferon inducer in viral respiratory disease
CT  - Evaluation of an interferon inducer in viral respiratory disease
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1972/02/28/
VL  - 219
IS  - Feb 28
SP  - 1179
EP  - 1184
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Bethesda, Maryland 20014
N1  - Accession Number: 9-2112; Language: English; Trade Name: Poly I:Poly C; Generic Name: Polyinosinic-polycytidylic acid; Chemical Name: Polyinosinic-polycytidylic acid--24939-03-5 Interferon--9008-11-1; Therapeutic Class: (8:18); AHFS Class: Virucides polyinosinic-polycytidylic acid; References: 17; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2  - To evaluate the effect of an interferon inducer on respiratory tract virus infection, poly I.poly C (polyinosinic-polycytidylic acid), a synthetic double-stranded RNA interferon inducer, was administered intranasally to volunteers for a 7 day period beginning one day prior to inoculation of rhinovirus 13 or type A2 influenza virus/Hong Kong/68. On the day before virus challenge, each volunteer was given 7.0 mg. (0.1 mg./kg.) of poly I.poly C divided into 14 intranasal doses of 0.5 mg. (0.5 ml.) administered one hour apart. The drug was administered by instillation of 0.25 ml. into each nostril by drops, after which the patient remained supine for 2 to 3 minutes. On the following day, all volunteers were challenged with virus by intranasal inoculation with drops. On this day and on the subsequent 5 days, each patient was given 3.5 mg. (0.05 mg./kg./day) of poly I.poly C (or saline diluent) per day in divided doses of 0.5 mg. (0.5 ml.) every 2 hours for 7 doses. In 3 separate trials, toxic effects were not detected and there was a small, but definite, reduction in symptoms of upper respiratory tract illness associated with drug treatment. However, there was a variable effect on the pattern of virus infection. In only one of the 2 rhinovirus studies was a reduction of virus shedding observed. Treatment did not decrease the shedding of type A2 influenza virus. The minimal amounts of nasal interferon stimulated by the intranasally administered poly I.poly C may have been responsible for the less-than-optimal results obtained.
KW  - Polyinosinic-polycytidylic acid--virucides-;
KW  - Interferon--inducers-;
KW  - Virucides--polyinosinic-polycytidylic acid--effects, on viral respiratory tract infections, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lee, H. G.;
T1  - Aspects on the effect of thioxanthone on Schistosoma mansoni in mice and in vitro
CT  - Aspects on the effect of thioxanthone on Schistosoma mansoni in mice and in vitro
JO  - Bull. WHO
JF  - Bull. WHO
Y1  - 1972/03/01/
VL  - 46
IS  - Mar
SP  - 397
EP  - 402
AD  - Laboratory of Parasitic Diseases, National Institutes of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014) (Reprint: George Williams Hooper Foundation, San Francisco Medical Center, University of California, San Francisco, California
N1  - Accession Number: 10-1127; Language: English; Chemical Name: Hycanthone--3105-97-3; References: 21; Journal Coden: BWHOA6; Section Heading: Preliminary Drug Testing; Abstract Author: Walter F. Stanaszek
N2  - The parasiticidal and sublethal effects of lucanthone and hycanthone were investigated in both male and female S. mansoni in infected mice and in vitro. Chemotherapy consisted of (1) 5 daily doses of lucanthone by gavage; (2) 5 daily doses of stibophen I.P.; or (3) a single I.M. dose of hycanthone base dissolved in castor oil. In vitro assays were performed with hycanthone methanesulfonate using the Lee-Michaels method. Results indicated that male worms were more susceptible to the lethal actions of the drugs than were females. It appeared that about 70% of male worms were killed with 25 mg./kg. of hycanthone vs. 30% of females with 50 mg./kg. The hycanthone methanesulfonate proved to be highly active against \IT/S. mansoni\OK/ in in vitro studies, again with a greater killing effect on male worms. In comparison with other antischistosomal drugs, thioxanthone treatment may warrant scrutiny in terms of its effect on prevalence and magnitude of reinfection.
KW  - Lucanthone--effects-;
KW  - Hycanthone--effects-;
KW  - Schistosomicides--lucanthone--effects, in vitro and in mice;
KW  - Schistosomicides--hycanthone--effects, in vitro and in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kay, D. C.;
AU  - Jasinski, D. R.;
AU  - Eisenstein, R. B.;
AU  - Kelly, O. A.;
T1  - Quantified human sleep after pentobarbital
CT  - Quantified human sleep after pentobarbital
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1972/03/01/
VL  - 13
IS  - Mar-Apr
SP  - 221
EP  - 231
SN  - 00099236
AD  - National Institute of Mental Health, Lexington, Kentucky
N1  - Accession Number: 10-1177; Language: English; Chemical Name: Pentobarbital--76-74-4; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics pentobarbital; References: 75; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Methodology; Pharmacology
N2  - Pentobarbital I.M. (75, 150, 300 mg./70 kg.) and placebo were given to 8 male post-addict subjects at weekly intervals. After 4 adaptation nights, the drug dosages were crossed over to show drug effects. Pentobarbital decreased rapid eye movement sleep (REMS) by decreasing the number and duration of REMS episodes and by delaying the onset of the first REMS episode, without measurably changing the period of the REMS cycle. It was suggested that the reduction of REMS and other sleep indicators can be used as a standard effect with which to determine equivalent doses of barbiturates and similar hypnotics.
KW  - Pentobarbital--effects-;
KW  - Sedatives and hypnotics--pentobarbital--effects, on sleep patterns, in former addicts;
KW  - Toxicity--pentobarbital--studies, effects, on sleep patterns, in former addicts;
KW  - Methodology--pentobarbital--effects, on sleep patterns, in former addicts;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Coe, J. E.
T1  - Studies on IgA of the Guinea-Pig.
JO  - Immunology
JF  - Immunology
Y1  - 1972/03//
VL  - 22
IS  - 3
M3  - Article
SP  - 333
EP  - 345
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The secretory immunoglobulin of the guinea-pig, IgA, was antigenically unique when compared with the 7Sγ1-, 7Sγ2- and γM-globulins, although it did share Fab determinants in common with the 7S&gamma2 globulin. Specific antigen binding capacity was detected in serum IgA after sequential oral and parenteral sensitization with purified protein antigens. IgA was prominent in saliva and succus entericus; in colostrum its concentration was 4–8 times that in normal serum. IgA in serum and secretory fluids sedimented at similar rates (≈12S), although colostral IgA contained an additional ≈16S population. Serum and secretory IgA appeared antigenically identical, however, serum IgA was especially sensitive to mild reductive procedures and became ≈7S after treatment. Serum IgA migrated as a β-protein on electrophoresis and was faster than IgA of colostrum. Antisera to IgA were produced by a procedure which involved simple precipitation of secretory IgA with an antiserum containing antibodies to common determinants of guinea-pig Ig. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - PROTEINS
KW  - SPUTUM
KW  - COLOSTRUM
KW  - IMMUNE serums
N1  - Accession Number: 14514637; Coe, J. E. 1; Affiliation:  1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Mar72, Vol. 22 Issue 3, p333; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEINS; Subject Term: SPUTUM; Subject Term: COLOSTRUM; Subject Term: IMMUNE serums; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Waters, J. A.;
AU  - Kondo, Y.;
AU  - Witkop, B.;
T1  - Photochemistry of steroids
CT  - Photochemistry of steroids
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1972/03/01/
VL  - 61
IS  - Mar
SP  - 321
EP  - 334
SN  - 00223549
AD  - Laboratory of Chemistry, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland 20014
N1  - Accession Number: 11-4487; Language: English; References: 128; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2  - Photorearrangements, photoadditions, photoreductions, and photooxidations are discussed in this review on the photochemistry of steroids. Numerous reactions are described, and the approaches are often applicable to other models besides steroids.
KW  - Steroids--photochemistry--review;
KW  - Photochemistry--steroids--review;
KW  - Stability--steroids--photochemistry, review;
KW  - Oxidation--steroids--photo, review of photochemistry;
KW  - Reduction--steroids--photo, review of photochemistry;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Hoel, David G.
T1  - An Inverse Stopping Rule for Play-the-Winner Sampling.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1972/03//
VL  - 67
IS  - 337
M3  - Article
SP  - 148
SN  - 01621459
AB  - Sobel and Weiss [2] have given an inverse sampling stopping rule for selecting the better of two binomial populations. Sampling is done by the play-the-winner method. By including the number of failures in the Sobel-Weiss stopping rule a truncated procedure is obtained with good general properties. In particular, excessive sample sizes are avoided when the population probabilities are small. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SAMPLING (Statistics)
KW  - MATHEMATICAL statistics
KW  - PROBABILITY theory
KW  - MATHEMATICAL models
KW  - STATISTICS
KW  - BINOMIAL distribution
KW  - SAMPLE size (Statistics)
KW  - WINNERS
KW  - POPULATION
N1  - Accession Number: 4603947; Hoel, David G. 1; Affiliations: 1: Mathematical statistician, Biometry Branch,  National institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, N.C. 27709.; Issue Info: Mar1972, Vol. 67 Issue 337, p148; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: SAMPLE size (Statistics); Subject Term: WINNERS; Subject Term: POPULATION; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - Random Counts in Scientific Work: Volume 1--Random Counts in Model, and Structure; Volume 2--Biomedical and Social Sciences, Volume 3--Physical Sciences, Geosciences and Business.
JO  - Operations Research
JF  - Operations Research
Y1  - 1972/03//Mar/Apr72
VL  - 20
IS  - 2
M3  - Book Review
SP  - 455
EP  - 456
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - Reviews the books "Random Counts in Scientific Work," Volume 1: Random Counts in Models and Structures, Volume 2: Biomedical and Social Sciences, and Volume 3: Physical Sciences, Geosciences and Business, edited by G. P. Patil.
KW  - SCIENCE
KW  - NONFICTION
KW  - PATIL, G. P.
KW  - RANDOM Counts in Scientific Work (Book)
N1  - Accession Number: 8604193; Weiss, George H. 1; Affiliations: 1: National Institutes of Health; Issue Info: Mar/Apr72, Vol. 20 Issue 2, p455; Subject Term: SCIENCE; Subject Term: NONFICTION; Reviews & Products: RANDOM Counts in Scientific Work (Book); People: PATIL, G. P.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - Computational Methods in Optimization, A Unified Approach.
JO  - Operations Research
JF  - Operations Research
Y1  - 1972/03//Mar/Apr72
VL  - 20
IS  - 2
M3  - Book Review
SP  - 456
EP  - 456
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - Reviews the book "Computational Methods in Optimization: A Unified Approach," by E. Polak.
KW  - MATHEMATICAL optimization
KW  - NONFICTION
KW  - POLAK, E.
KW  - COMPUTATIONAL Methods in Optimization: A Unified Approach (Book)
N1  - Accession Number: 8604195; Weiss, George H. 1; Affiliations: 1: National Institutes of Health; Issue Info: Mar/Apr72, Vol. 20 Issue 2, p456; Thesaurus Term: MATHEMATICAL optimization; Subject Term: NONFICTION; Reviews & Products: COMPUTATIONAL Methods in Optimization: A Unified Approach (Book); People: POLAK, E.; Number of Pages: 1/2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - FLAMM, W. G.
AU  - FISHBEIN, L.
T1  - Mutagenic Agents.
JO  - Science
JF  - Science
Y1  - 1972/03/03/
VL  - 175
IS  - 4025
M3  - Article
SP  - 980
EP  - 980
SN  - 00368075
N1  - Accession Number: 85160010; FLAMM, W. G. 1; FISHBEIN, L. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Issue Info: 3/ 3/1972, Vol. 175 Issue 4025, p980; Number of Pages: 1/2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - HANKER, JACOB S.
AU  - ANDERSON, WINSTON A.
AU  - BLOOM, FLOYD E.
T1  - Osmiophilic Polymer Generation: Catalysis by Transition Metal Compounds in Ultrastructural Cytochemistry.
JO  - Science
JF  - Science
Y1  - 1972/03/03/
VL  - 175
IS  - 4025
M3  - Article
SP  - 991
EP  - 993
SN  - 00368075
AB  - A transition metal compound that is bound in tissues by any appropriate cytochemical reaction may catalyze the generation of an insoluble osmiophilic polymer from organic monomers such as 3,3'-diaminobenzidine. When the polymers are treated with osmium tetroxide, electron-opaque, insoluble osmium blacks (coordination polymers of osmium) are formed at the sites of the particular macromolecule or enzyme permitting its light, and electron, microscopic localization. This approach represents a distinct advantage over earlier cytochemical methods because the shorter incubation time needed here results in less artifactual deposition of metal ions, and less tendency to crystallize the reaction product. In addition, the shorter incubation times permit longer fixation of tissues and hence less artifact due to enzyme diffusion. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160016; HANKER, JACOB S. 1; ANDERSON, WINSTON A. 2; BLOOM, FLOYD E. 3; Affiliations: 1: Dental Research Center, School of Dentistry, University of North Carolina, Chapel Hill 27514; 2: Department of Anatomy, University of Chicago, Chicago, Illinois 60637; 3: Laboratory of Neuropharmacology, Division of Special Mental Health, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 3/1972, Vol. 175 Issue 4025, p991; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - FREESE, ERNST
T1  - Prospects of Gene Therapy.
JO  - Science
JF  - Science
Y1  - 1972/03/03/
VL  - 175
IS  - 4025
M3  - Article
SP  - 1024
EP  - 1025
SN  - 00368075
N1  - Accession Number: 85160033; FREESE, ERNST 1; Affiliations: 1: Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/ 3/1972, Vol. 175 Issue 4025, p1024; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Duttera, M. J.;
AU  - Gallelli, J. F.;
AU  - Kleinman, L. M.;
AU  - Tangrea, J. A.;
AU  - Wittgrove, A. C.;
T1  - Intrathecal methotrexate
CT  - Intrathecal methotrexate
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1972/03/04/
VL  - 1
IS  - Mar 4
SP  - 540
SN  - 00237507
AD  - Leukemia Service, Medicine, Branch, National Cancer Institute; and Pharmacy and Pharmaceutical Development Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-2411; Language: English; Trade Name: Cytosine arabinoside; Generic Name: Cytarabine; Chemical Name: Methotrexate--59-05-2 Cytarabine--147-94-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents cytarabine; References: 8; Publication Type: Letters; Journal Coden: LANCAO; Section Heading: Pharmaceutics; Abstract Author: Joan Lentine
N2  - Data are presented which illustrate the wide variation in pH and osmolarity that can occur depending on how methotrexate and cytosine arabinoside (cytarabine) are prepared for intrathecal injection. Solutions used to reconstitute the samples included Sodium Chloride Injection \IT/U.S.P.\OK/, Bacteriostatic Water for Injection \IT/U.S.P.\OK/, and Elliott's B solution (an artificial spinal fluid containing in each ml. 7.3 mg. NaCl, 0.3 mg. Kcl, 0.2 mg. CaCl\IF/2\BS/.2 H\IF/2\BS/O, 0.3 mg. MgSO\IF/4\BS/. 7 H\IF/2\BS/O, 0.2 mg. sodium phosphate, dibasic 7H\IF/2\BS/O, 0.8 mg. dextrose, 1.9 mg. sodium bicarbonate, and 0.1 mcg. phenol red). In reconstituting both methotrexate and cytosine arabinoside, the most nearly physiological solution was obtained by using Elliott's B solution exclusively. The use of Elliott's B solution is recommended to prevent administration of intrathecal drugs which have unphysiological \IT/p\OK/H and osmolarity.
KW  - Methotrexate--injections-;
KW  - Cytarabine--injections-;
KW  - Injections--methotrexate--intrathecal, diluents cause variation in pH and osmolarity;
KW  - Antineoplastic agents--methotrexate--injections, intrathecal, diluents cause variation in pH and osmolarity;
KW  - Hydrogen ion concentration--methotrexate--injections, intrathecal, variation due to diluents;
KW  - Injections--cytarabine--intrathecal, diluents cause variation in pH and osmolarity;
KW  - Antineoplastic agents--cytarabine--injections, intrathecal, diluents cause variation in pH and osmolarity;
KW  - Hydrogen ion concentration--cytarabine--injections, intrathecal, variation due to diluents;
KW  - Vehicles--injections--varying pH in cytarabine and methotrexate due to diluents;
KW  - Osmolarity--methotrexate--injections, intrathecal, variation due to diluents;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - SAROFF, H. A.
AU  - MINTON, ALLEN P.
T1  - The Hill Plot and the Energy of Interaction in Hemoglobin.
JO  - Science
JF  - Science
Y1  - 1972/03/17/
VL  - 175
IS  - 4027
M3  - Article
SP  - 1253
EP  - 1255
SN  - 00368075
AB  - The Hill plot does not independently yield the average free energy of interaction per binding site, as has been proposed by Wyman, but rather the diflerence between the free energies of interaction on binding the first and last ligands. It is shown that additional data (or assumptions) and a model for cooperative behavior are requtired to obtain the average free energy of interaction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85198745; SAROFF, H. A. 1; MINTON, ALLEN P. 1; Affiliations: 1: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Bethesda, Maryland 20014; Issue Info: 3/17/1972, Vol. 175 Issue 4027, p1253; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SAAVEDRA, JUAN M.
AU  - AXELROD, JULIUS
T1  - Psychotoniimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro.
JO  - Science
JF  - Science
Y1  - 1972/03/24/
VL  - 175
IS  - 4028
M3  - Article
SP  - 1365
EP  - 1366
SN  - 00368075
AB  - The use of a sensitive enzymatic assay demonstrates that tryptamine occurs normally in rat brain. Intracisternal administration of [(14)C]tryptamine results in the formation of N-methyl-and dimethyltryptamine(a psychotomimetic compound)in the rat brain. An enzyme that converts tryptamine and N-methyl-tryptamine to N-methyl-and dimethyltryptamine was found to be present in rat and human brain. The N-methylation of tryptamine was inhibited by normally occurring compounds present in rat brain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437463; SAAVEDRA, JUAN M. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/24/1972, Vol. 175 Issue 4028, p1365; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PETRICCIANI, JOHN C.
AU  - BINDER, MARC K.
AU  - MERRIL, CARL R.
AU  - GEIER, MARK R.
T1  - Galactose Utilization in Galactosemia.
JO  - Science
JF  - Science
Y1  - 1972/03/24/
VL  - 175
IS  - 4028
M3  - Article
SP  - 1368
EP  - 1370
SN  - 00368075
AB  - Cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [1-14C]galactose to 14CO2 to the same extent as normal cells, but did so at a significantly slower rate. The utilization of galactose in both normal and galactosemic cells was strongly inhibited by glucose at physiologic concentrations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437465; PETRICCIANI, JOHN C. 1; BINDER, MARC K. 1; MERRIL, CARL R. 2; GEIER, MARK R. 2; Affiliations: 1: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/24/1972, Vol. 175 Issue 4028, p1368; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Lemberger, L.;
AU  - Weiss, J. L.;
AU  - Watanabe, A. M.;
AU  - Galanter, I. M.;
AU  - Wyatt, R. J.;
AU  - \ET/;
T1  - Delta-9-tetrahydrocannabinol: temporal correlation of the psychologic effects and blood levels after various routes of administration
CT  - Delta-9-tetrahydrocannabinol: temporal correlation of the psychologic effects and blood levels after various routes of administration
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/03/30/
VL  - 286
IS  - Mar 30
SP  - 685
EP  - 688
SN  - 00284793
AD  - reprints: Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana 46202
AD  - Laboratory of Clinical Science and the Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, and the National Institute of General Medical Sciences, Bethesda, Maryland 20014
N1  - Accession Number: 9-3452; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Cannabis--8063-14-7; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; BiopharmaceuticsPharmacology
N2  - \D/\SU/9\BS/-Tetrahydrocannabinol (\SU/14\BS/C-\D/\SU/9\BS/-THC) was administered to 12 long-term marihuana (cannabis) smokers I.V., orally or by inhalation, and the drug's disposition, excretion and psychologic effects compared. All subjects received a dose of 10 \mu/Ci of \SU/14\BS/C-\D/\SU/9\BS/-THC. For I.V. administration, radiolabeled \D/\SU/9\BS/-THC (10 \mu/Ci; total \D/\SU/9\BS/-THC, 0.5 mg.) was prepared by aseptic techniques and dissolved in absolute alcohol for parenteral administration. For oral administration, \SU/14\BS/C-\D/\SU/9\BS/-THC (10 \mu/Ci) was diluted with a pharmacologic dose of nonradiolabeled \D/\SU/9\BS/-THC (0.3 mg./kg.) and added to cherry syrup \IT/USP \OK/to disguise its unpleasant taste. In the studies in which the drug was administered by inhalation, \SU/14\BS/C-\D/\SU/9\BS/-THC (10 \mu/Ci) was diluted with an alcoholic solution containing a pharmacologic dose of nonradiolabeled \D/\SU/9\BS/-THC (10 mg.). The final solution was divided into 2 equal portions and added throughout the length of 2 placebo-marihuana cigarettes up to a point delineated by an inked spot. Over 90% of the dose was absorbed after oral administration; the psychologic effects and plasma levels of metabolites of \D/\SU/9\BS/-THC peaked at 3 hours. After inhalation, the peak psychologic #OQ#OQhigh'' ranged from 10 to 140 minutes (average peak #OQ#OQhigh'' of 70 minutes), correlating well with the peak plasma levels of metabolites of \D/\SU/9\BS/-THC. The percentage of administered radioactive dose excreted in urine during the first day was similar after oral and I.V. routes, but the proportion of radioactivity recovered from feces (7 days) exceeded that in the one-day urine output. The fact that the psychologic effects in response to pharmacologic doses of ingested or inhaled \SU/14\BS/C-\D/\SU/9\BS/-THC were temporally correlated with plasma levels of the metabolites of the drug supports the hypothesis that these metabolites are active compounds.
KW  - Tetrahydrocannabinol--effects-;
KW  - Cannabis--derivatives-;
KW  - Blood levels--tetrahydrocannabinol--correlation, to psychologic effects, in cannabis smokers, various routes of administration;
KW  - Metabolism--tetrahydrocannabinol--blood levels, correlation, to psychologic effects, in cannabis smokers, various routes of administration;
KW  - Drug administration--tetrahydrocannabinol--routes, in cannabis smokers, correlation of psychologic effects to blood levels;
KW  - Excretion--tetrahydrocannabinol--in cannabis smokers, various routes of administration;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - TESH, ROBERT B.
AU  - CHANIOTIS, BYRON N.
AU  - JOHNSON, KARL M.
T1  - Vesicular Stomatitis Virus (Indiana Serotype): Transovarial Transmission by Phlebotomine Sandflies.
JO  - Science
JF  - Science
Y1  - 1972/03/31/
VL  - 175
IS  - 4029
M3  - Article
SP  - 1477
EP  - 1479
SN  - 00368075
AB  - Transovarial transmission of vesicular stomatitis virus (Indiana sero-type) by experimentally infected Lutzomyia trapidoi and Lutzomyia ylephiletrix to their progeny was demonstrated. Virus was recovered from all developmental stages; mean virus titers from egg to first generation adult showed a four-log increase, indicating that virus multiplication occurred during development of the sandflies. Virus titers in first generation adult females were comparable to those found in their parents. These infected female sandflies transmitted vesicular stoma titus virus Indiana by bite to susceptible animals and transmitted the virus transovarially to their offspring (second generation). Results demonstrate a possible mechanism for transmission and maintenance of this virus in nature without a vertebrate (heat) host reservoir. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160069; TESH, ROBERT B. 1; CHANIOTIS, BYRON N. 1; JOHNSON, KARL M. 1; Affiliations: 1: U.S. Public Health Service, National Institute of Allergy and infectious Diseases, Middle America Research Unit, Balboa Heights, Canal Zone; Issue Info: 3/31/1972, Vol. 175 Issue 4029, p1477; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SIMS, K. L.
AU  - WEITSEN, H. A.
AU  - BLOOM, F. E.
T1  - GABA Catabolism: Localization of Succinic Semialdehyde Dehydrogenase in Brain Motor and Sensory Nuclei.
JO  - Science
JF  - Science
Y1  - 1972/03/31/
VL  - 175
IS  - 4029
M3  - Article
SP  - 1479
EP  - 1480
SN  - 00368075
AB  - The localization of brain succinic semialdehyde dehydrogenase, a specific gamma-aminobutyric acid degradative enzyme, could potentially yield valuable information concerning the function of the enzyme. Application of a new histochemical technique for this enzyme has revealed characteristic patterns of neuronal staining that are contsistent within embryologically and functionally similar nuclei of ihe brainstem of the rat. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160070; SIMS, K. L. 1; WEITSEN, H. A. 1; BLOOM, F. E. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/31/1972, Vol. 175 Issue 4029, p1479; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hiranaka, P. K.;
AU  - Frazier, A. G.;
AU  - Gallelli, J. F.;
T1  - Stability of sodium ampicillin in aqueous solutions
CT  - Stability of sodium ampicillin in aqueous solutions
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1972/04/01/
VL  - 29
IS  - Apr
SP  - 321
EP  - 322
SN  - 00029289
AD  - Pharmacy Department, The Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-2422; Language: English; Chemical Name: Ampicillin--69-53-4; Therapeutic Class: (8:12); AHFS Class: Antibiotics ampicillin; References: 4; Journal Coden: AJHPA9; Section Heading: Drug Stability
N2  - A stability study of sodium ampicillin in aqueous solutions was carried out in order to determine the effects of various concentrations on the activity of the antibiotic with time. The need for such specific data is essential because the stability of the drug is not only very much dependent on its vehicle, \IT/p\OK/H and temperature, but also on its concentration. Sodium ampicillin was studied at various concentrations (0.5, 1, 1.5, 2, 3 and 4 g./100 ml.) in 5% Dextrose Injection, U.S.P., and Sodium Chloride Injection, U.S.P., at 25 and 5\DG/C. Each sample solution was colorimetrically assayed and its \IT/p\OK/H recorded for one week. Results indicated that the stability of the drug is definitely concentration dependent, especially in sodium chloride injection where the lower concentrations were more stable (94% potency for a 0.5 g./100 ml. solution versus 85% potency for a 4.0 g./100 ml. solution after 24 hours at 25\DG/C.). All solutions at 5\DG/C. in Sodium Chloride Injection, U.S.P., were stable for 72 hours with the lower concentrations being more stable. A 5% Dextrose Injection, U.S.P., should not be used as a vehicle for sodium ampicillin, and if it is used, one should be aware that the solution is stable only for 4 hours at 5\DG/C. and less than 4 hours at 25\DG/C.
KW  - Ampicillin--sodium-;
KW  - Antibiotics--ampicillin--sodium, stability, in aqueous solutions, effects of concentration;
KW  - Stability--ampicillin--sodium, in aqueous solutions, effects of concentration;
KW  - Additives--injections--ampicillin, sodium, stability, in aqueous solutions, effects of concentration;
KW  - Injections--ampicillin--sodium, stability, in aqueous solutions, effects of concentration;
KW  - Concentration--effects--on stability of sodium ampicillin in aqueous solutions;
KW  - Vehicles--ampicillin--sodium, stability, in aqueous solutions, effects of concentration;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Smiley, Jane
AU  - Eyres, Sandra
AU  - Roberts, Doris E.
T1  - Maternal and Infant Health and Their Associated Factors in an Inner City Population.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/04//
VL  - 62
IS  - 4
M3  - Article
SP  - 476
EP  - 482
PB  - American Public Health Association
SN  - 00900036
AB  - This study identifies characteristics of infants and their families which may predict infant illness and failure to use preventive care following delivery. These characteristics are employed to develop a predictive model which may be further tested for usefulness. The need for attention to certain mothers is stressed, as are also the implications for public health nursing service. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Public health
KW  - Infant diseases
KW  - Nursing services
KW  - Nurse & patient
KW  - Medical care
KW  - Health education
KW  - Preventive medicine
N1  - Accession Number: 24294089; Smiley, Jane 1; Eyres, Sandra 2; Roberts, Doris E. 3; Affiliations: 1: Maternal and Child Health Consultant, VNA of Detroit; 2: Nurse Consultant in Research, Nursing Practice Branch, Division of Nursing, National Institutes of Health; 3: Chief, Nursing Practice Branch, Division of Nursing, National Institutes of Health; Issue Info: Apr1972, Vol. 62 Issue 4, p476; Thesaurus Term: Public health; Subject Term: Infant diseases; Subject Term: Nursing services; Subject Term: Nurse & patient; Subject Term: Medical care; Subject Term: Health education; Subject Term: Preventive medicine; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Basco, Dolores
AU  - Eyres, Sandra
AU  - Glasser, Jay H.
AU  - Roberts, Doris E.
T1  - Epidemiologic Analysis in School Populations as a Basis for Change in School-Nursing Practice -- Report of the Second Phase of a Longitudinal Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/04//
VL  - 62
IS  - 4
M3  - Article
SP  - 491
EP  - 497
PB  - American Public Health Association
SN  - 00900036
AB  - A report is presented on the second phase of a study intended to elucidate factors that influence the health status and social functioning of school populations, Implications of the findings for school health nursing are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - School nursing
KW  - School health services
KW  - Medical care
KW  - Pediatrics
KW  - Social functions
KW  - Public health personnel
N1  - Accession Number: 24294091; Basco, Dolores 1; Eyres, Sandra 1; Glasser, Jay H. 2; Roberts, Doris E. 3; Affiliations: 1: Nurse Consultants, Nursing Practice Branch, Division of Nursing, Bureau of Health Manpower Education, National Institutes of Health, HEW; 2: Associate Professor of Biostatistics, University of Texas, Houston; 3: Chief, Nursing Practice Branch, Division of Nursing, Bureau of Health Manpower Education, National Institutes of Health, HEW; Issue Info: Apr1972, Vol. 62 Issue 4, p491; Subject Term: School nursing; Subject Term: School health services; Subject Term: Medical care; Subject Term: Pediatrics; Subject Term: Social functions; Subject Term: Public health personnel; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Li, Frederick P.
AU  - Schlief, Nyuk Yoong
AU  - Chang, Caroline J.
AU  - Gaw, Albert C.
T1  - Health Care for the Chinese Community in Boston.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/04//
VL  - 62
IS  - 4
M3  - Article
SP  - 536
EP  - 539
PB  - American Public Health Association
SN  - 00900036
AB  - Poor health and low living standards prevail in Chinese-American communities. This report discusses some social and cultural origins of health needs among Chinese-Americans and describes the role of community participation in health programming for one Chinese community, the Chinatown of Boston. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Public health
KW  - Medical care
KW  - Health planning
KW  - Health promotion
KW  - Socioeconomic factors
KW  - United States
N1  - Accession Number: 24294098; Li, Frederick P. 1,2; Schlief, Nyuk Yoong 1,3; Chang, Caroline J. 1,4; Gaw, Albert C. 1,5; Affiliations: 1: Members of the Chinese Community Health Task Force of Boston, Mass; 2: Research Associate, Epidemiology Branch, National Cancer Institute, Field Station, 35 Binney Street, Boston, Mass. 02715; 3: Health Educator, Boston Tuberculosis and Respiratory Disease Association, Little City Hall, Chinatown, Boston; 4: Director, Little City Hall, Chinatown, Boston; 5: Assistant Professor of Psychiatry, Tufts-New England Medical Center; Issue Info: Apr1972, Vol. 62 Issue 4, p536; Thesaurus Term: Public health; Subject Term: Medical care; Subject Term: Health planning; Subject Term: Health promotion; Subject Term: Socioeconomic factors; Subject: United States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Smith, J. W.;
AU  - Utz, J. P.;
T1  - Progressive disseminated histoplasmosis. A prospective study of 26 patients
CT  - Progressive disseminated histoplasmosis. A prospective study of 26 patients
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/04/01/
VL  - 76
IS  - Apr
SP  - 557
EP  - 565
SN  - 00034819
AD  - reprints: Infectious Disease Section, Veterans Administration Hospital, 4500 South Lancaster Road, Dallas, Texas 75216
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 9-4185; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 51; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The clinical, laboratory, and histopathologic features of progressive disseminated histoplasmosis in 26 patients were studied prospectively. Amphotericin B was an effective agent in most patients, but relapses of infection occurred in half of those with favorable response.
KW  - Amphotericin B--histoplasmosis-;
KW  - Antibiotics, antifungal--amphotericin B--histoplasmosis, progressive disseminated, therapy, in patients;
KW  - Histoplasmosis--progressive disseminated--prospective study of patients, including value of amphotericin B therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Steinberg, A. D.;
AU  - Plotz, P. H.;
AU  - Wolff, S. M.;
AU  - Wong, V. G.;
AU  - Agus, S. G.;
AU  - \ET/;
T1  - Cytotoxic drugs in treatment of nonmalignant diseases
CT  - Cytotoxic drugs in treatment of nonmalignant diseases
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/04/01/
VL  - 76
IS  - Apr
SP  - 619
EP  - 642
SN  - 00034819
AD  - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-0098; Language: English; References: 288; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2  - The basis for using cytotoxic drugs in inflammatory diseases of uncertain cause is their immunosuppressive properties. These drugs interrupt nucleic acid and protein synthesis, thereby inhibiting various immune responses at different stages. Specific inhibition of an immune response is possible through drug-induced tolerance. Many of the agents have anti-inflammatory properties that may be a major factor in their efficacy. In short-term controlled trials, both cyclophosphamide and azathioprine have been useful in treatment of rheumatoid arthritis and systemic lupus erythematosus, cyclophosphamide in nephrosis, and methotrexate and azathioprine in psoriasis and psoriatic arthritis. Azathioprine was ineffective in iridocyclitis, nephritis, nephrosis, Crohn's disease, chronic hepatitis, and asthma. Cytotoxic drugs may increase the risk of infection, predispose to malignancy, and increase mutations in offspring. Specific side effects include hemorrhagic cystitis from cyclophosphamide, cirrhosis from methotrexate, and altered germ cell production by alkylating agents. Only long-term controlled trials, not uncontrolled reports or positive short-term controlled trials, will justify widespread clinical use of these drugs in inflammatory diseases.
KW  - Antineoplastic agents--therapy--of nonmalignant diseases, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - STETTEN JR., DEWITT
T1  - Letters.
JO  - Science
JF  - Science
Y1  - 1972/04/07/
VL  - 176
IS  - 4030
M3  - Article
SP  - 8
EP  - 8
SN  - 00368075
N1  - Accession Number: 87562569; STETTEN JR., DEWITT 1; Affiliations: 1: National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 4/7/1972, Vol. 176 Issue 4030, p8; Number of Pages: 1/5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Frank, M. M.;
AU  - Sergent, J. S.;
AU  - Kane, M. A.;
AU  - Alling, D. W.;
T1  - Epsilon aminocaproic acid therapy of hereditary angioneurotic edema: double-blind study
CT  - Epsilon aminocaproic acid therapy of hereditary angioneurotic edema: double-blind study
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/04/13/
VL  - 286
IS  - Apr 13
SP  - 808
EP  - 812
SN  - 00284793
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 11N104, Building 10, Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 9-4183; Language: English; Chemical Name: Aminocaproic acid--60-32-2; Therapeutic Class: (20:12.16); AHFS Class: Hemostatics aminocaproic acid; References: 35; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - Five patients with hereditary angioneurotic edema were treated with a sequence of courses of epsilon aminocaproic acid (EACA) or placebo in a double-blind study. Attacks of edema were significantly less frequent during administration of EACA in 4 patients. The principal adverse side effects of EACA\M/muscle pain and weakness, accompanied by elevations in the serum enzymes creatine phosphokinase and aldolase\M/were usually observed when the dose of drug exceeded 20 g./day, but disappeared when the drug was discontinued or the dosage was lowered. After completion of the study, patients had their dosage gradually lowered and have been maintained on 7 to 10 g. of EACA per day in 4 divided doses. All patients except one continued to do well on this dosage schedule.
KW  - Aminocaproic acid--edema-;
KW  - Hemostatics--aminocaproic acid--edema, angioneurotic, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Mulvihill, John J.
T1  - Congenital and Genetic Disease in Domestic Animals.
JO  - Science
JF  - Science
Y1  - 1972/04/14/
VL  - 176
IS  - 4031
M3  - Article
SP  - 132
EP  - 137
SN  - 00368075
N1  - Accession Number: 85160088; Mulvihill, John J. 1; Affiliations: 1: Staff Associate, Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/14/1972, Vol. 176 Issue 4031, p132; Number of Pages: 6p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KOPIN, IRWIN J.
T1  - Neurochemistry.
JO  - Science
JF  - Science
Y1  - 1972/04/14/
VL  - 176
IS  - 4031
M3  - Article
SP  - 156
EP  - 156
SN  - 00368075
N1  - Accession Number: 85160099; KOPIN, IRWIN J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 4/14/1972, Vol. 176 Issue 4031, p156; Number of Pages: 1/3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - KOSLOW, S. H.
AU  - CATTABENI, F.
AU  - COSTA, E.
T1  - Norepinephrine and Dopamine: Assay by Mass Fragmentography in the Picomole Range.
JO  - Science
JF  - Science
Y1  - 1972/04/14/
VL  - 176
IS  - 4031
M3  - Article
SP  - 177
EP  - 180
SN  - 00368075
AB  - Gas chromatography-mass spectrometry makes possible the simultaneous measurement of norepinephrine and dopamine in concentrations of 0.1- milligram tissue samples. Specificity of the assay is confirmed both by the retention time of the compound and by the mass to charge ratio of the fragments recorded. The sensitivity is of the order of 0.5 picomole, and linearity of the response is maintained up to at least 200 picomoles. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160112; KOSLOW, S. H. 1; CATTABENI, F. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 4/14/1972, Vol. 176 Issue 4031, p177; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FRIEDLAENDER, MITCHELL H.
AU  - BAER, HAROLD
T1  - lmmunologic Tolerance: Role of the Regional Lymph Node.
JO  - Science
JF  - Science
Y1  - 1972/04/21/
VL  - 176
IS  - 4032
M3  - Article
SP  - 312
EP  - 314
SN  - 00368075
AB  - Dansyl chloride, a skin setnsitizer when injected in complete Freund's adjuvant, induced marked tolerance and no sensitization when applied to the intact skin of guinea pigs. Application of this chemical to alymphatic skin islands failed to induce tolerance or sensitization. Lymnphatic connections between skin and regional lymph nodes were essential for the developmnent of ismmunologic tolerance. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160165; FRIEDLAENDER, MITCHELL H. 1; BAER, HAROLD 1; Affiliations: 1: Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/21/1972, Vol. 176 Issue 4032, p312; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - DALTON, ALBERT J.
AU  - STEWART, SARAH E.
T1  - Intracisternal A Particles and C Particles.
JO  - Science
JF  - Science
Y1  - 1972/04/21/
VL  - 176
IS  - 4032
M3  - Article
SP  - 319
EP  - 319
SN  - 00368075
N1  - Accession Number: 85160169; DALTON, ALBERT J. 1,2; STEWART, SARAH E. 1,2; Affiliations: 1: Office, Associate Scientific Director, Viral Oncology, National Cancer Institute, Bethesda, Maryland 20014; 2: Pathology Department, Georgetown University Medical School, Washington, D.C. 20007; Issue Info: 4/21/1972, Vol. 176 Issue 4032, p319; Number of Pages: 2/3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - LANCASTER, F. WILFRID
AU  - SCHNEIDER, JOHN H.
T1  - Selective Dissemination.
JO  - Science
JF  - Science
Y1  - 1972/04/28/
VL  - 176
IS  - 4033
M3  - Article
SP  - 434
EP  - 437
SN  - 00368075
N1  - Accession Number: 85160212; LANCASTER, F. WILFRID 1; SCHNEIDER, JOHN H. 2; Affiliations: 1: Graduate School of Library Science, University of Illinois, Urbana 61801; 2: Scientific and Technical Information Office, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/28/1972, Vol. 176 Issue 4033, p434; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - GEN
AU  - Cargille, Charles M.
AU  - Sager, Martha C.
T1  - Proposal for a World Data Bank.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/05//
VL  - 62
IS  - 5
M3  - Letter
SP  - 626
EP  - 626
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article about mass computer storage systems for information search and retrieval capabilities published in the previous issue.
KW  - Letters to the editor
KW  - Computer storage devices
N1  - Accession Number: 24294122; Cargille, Charles M. 1; Sager, Martha C. 2; Affiliations: 1: National Institute of Child Health and Human Development, Bethesda, Md. 20014; 2: American University, Washington, D.C.; Issue Info: May1972, Vol. 62 Issue 5, p626; Subject Term: Letters to the editor; Subject Term: Computer storage devices; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 334112 Computer Storage Device Manufacturing; Number of Pages: 2/3p; Document Type: Letter
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DB  - eih
ER  - 

TY  - JOUR
AU  - Tillack, Warner S.
AU  - Tyler Jr., Carl W.
AU  - Paquette, Rick
AU  - Jones, Phillip H.
T1  - A Study of Premarital Pregnancy.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/05//
VL  - 62
IS  - 5
M3  - Article
SP  - 676
EP  - 679
PB  - American Public Health Association
SN  - 00900036
AB  - A study of premarital pregnancy in all women under 30 living in a single county who first married in 1968 is reported. The proportion of brides pregnant at marriage declined with higher age at marriage and with increased education. During the year of study the out-of-wedlock births were only about one-third of the total premarital pregnancies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Social surveys
KW  - Unwanted pregnancy
KW  - Single mothers
KW  - Single parents
KW  - Pregnant women
KW  - Prenatal care
KW  - First pregnancy
KW  - Prenatal influences
KW  - Maternal health services
N1  - Accession Number: 24294139; Tillack, Warner S. 1; Tyler Jr., Carl W. 2; Paquette, Rick 3; Jones, Phillip H. 4; Affiliations: 1: Demographer, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda. Maryland; 2: Chief, Family Planning Evaluation Activity, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda. Maryland; 3: Research Analyst, Management Information Section, Division of Health, Department of Social and Health Services, Olympia, Washington 98501; 4: District Health Officer, Bellingham and Whatcom District, Department of Public Health, 509 Girard St., Bellingham, Washington 98225; Issue Info: May1972, Vol. 62 Issue 5, p676; Subject Term: Social surveys; Subject Term: Unwanted pregnancy; Subject Term: Single mothers; Subject Term: Single parents; Subject Term: Pregnant women; Subject Term: Prenatal care; Subject Term: First pregnancy; Subject Term: Prenatal influences; Subject Term: Maternal health services; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Friedewald, W. T.;
AU  - Halperin, M.;
T1  - Clofibrate in ischemic heart disease
CT  - Clofibrate in ischemic heart disease
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/05/01/
VL  - 76
IS  - May
SP  - 821
EP  - 823
SN  - 00034819
AD  - Biometrics Research Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 10-0270; Language: English; Chemical Name: Clofibrate--637-07-0; Therapeutic Class: (24:06); AHFS Class: Antilipemic agents clofibrate (24:04); AHFS Class: Cardiac drugs clofibrate; References: 6; Publication Type: Editorials; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2  - Two recent studies on clofibrate are discussed. Although there is some indication in both trials of benefit from clofibrate, the authors raise several points about the study and suggest the need for further verification.
KW  - Clofibrate--therapy-;
KW  - Antilipemic agents--clofibrate--therapy, in ischemic heart disease, discussion;
KW  - Cardiac drugs--clofibrate--therapy, in ischemic heart disease, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gelfand, M. C.;
AU  - Steinberg, A. D.;
AU  - Nagle, R.;
AU  - Knepshield, J. H.;
T1  - Therapeutic studies in NZB/W mice. I. Synergy of azathioprine cyclophosphamide, and methylprednisolone in combination
CT  - Therapeutic studies in NZB/W mice. I. Synergy of azathioprine cyclophosphamide, and methylprednisolone in combination
JO  - Arthritis and Rheumatism (USA)
JF  - Arthritis and Rheumatism (USA)
Y1  - 1972/05/01/
VL  - 15
IS  - May-Jun
SP  - 239
EP  - 246
SN  - 00043591
AD  - Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Maryland 20012) (Reprints: Department of Nephrology, Walter Reed General Hospital, Box 216, Washington, D.C. 20012
N1  - Accession Number: 10-1067; Language: English; Chemical Name: Azathioprine--446-86-6 Cyclophosphamide--6055-19-2 Methylprednisolone--83-43-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents azathioprine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (68:04); AHFS Class: Steroids, cortico- methylprednisolone; Journal Coden: ARHEAW; Section Heading: Drug Evaluations
N2  - The study compares different immunosuppressive regimens of azathioprine, cyclophosphamide, and methylprednisolone in the treatment of lupus-like nephritis of NZB/W mice. A group of 5-month-old female NZB/W mice were given azathioprine, cyclophosphamide, and methylprednisolone in all one-, two-, and three-drug regimens, each drug in the relatively low dose of 1.5 mg./kg./day. Treatment for 3 months with one or 2 drugs resulted in modest suppression of lupus-like nephritis. Mice receiving all 3 drugs had significantly less proteinuria, lower titers of anti-DNA antibody and less severe, histologically evident renal involvement than mice treated with one or 2 drugs. Survival at one year was 10% for untreated controls, 44% for one-drug treated, 37% for two-drug treated, and 86% for three-drug treated mice. The survival for the three-drug regimen was significantly longer than any other group (P[0.01).] The beneficial effects of triple drug therapy were attained without increased toxicity. Based on these results, a controlled evaluation of triple drug therapy in human systemic lupus erythematosus appears warranted.
KW  - Azathioprine--alone and with cyclophosphamide and methylprednisolone-;
KW  - Cyclophosphamide--alone and with azathioprine and methylprednisolone-;
KW  - Methylprednisolone--alone and with azathioprine and cyclophosphamide-;
KW  - Immunosuppressive agents--azathioprine--alone and with cyclophosphamide and methylprednisolone, nephritis, lupus-like, therapy, in mice;
KW  - Antineoplastic agents--cyclophosphamide--alone and with azathioprine and methylprednisolone, nephritis, lupus-like, therapy, in mice;
KW  - Steroids, cortico---methylprednisolone--alone and with azathioprine and cyclophosphamide, nephritis, lupus-like, therapy, in mice;
KW  - Combined therapy--antineoplastic agents--nephritis, lupus-like, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Huffman, D. H.;
AU  - Bachur, N. R.;
T1  - Daunorubicin metabolism in acute myelocytic leukemia
CT  - Daunorubicin metabolism in acute myelocytic leukemia
JO  - Blood
JF  - Blood
Y1  - 1972/05/01/
VL  - 39
IS  - May
SP  - 637
EP  - 643
AD  - Biochemistry Section, Laboratory of Pharmacology, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1  - Accession Number: 12-2853; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 24; Journal Coden: BLOOAW; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Jimmie L. Hall
N2  - The conversion of daunorubicin (daunomycin) to its active metabolite daunorubicinol by means of daunorubicin reductase in leukemia patients is reported.
KW  - Daunomycin--metabolism-;
KW  - Metabolism--daunomycin--conversion, enzyme, to daunorubicinol, in leukemia patients;
KW  - Antineoplastic agents--daunomycin--metabolism, enzyme conversion to daunorubicinol, in leukemia patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06118-013
AN  - 2006-06118-013
AU  - Plaut, Thomas F. A.
T1  - Is the Flask Old-Fashioned?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1972/05//
VL  - 17
IS  - 5
SP  - 277
EP  - 278
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06118-013. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Plaut, Thomas F. A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: College Students; Drinking Behavior; Drug Education; Social Issues. Classification: Drug & Alcohol Usage (Legal) (2990); Educational/Vocational Counseling & Student Services (3580). Population: Human (10). Reviewed Item: Maddox, George L. (Ed). The Domesticated Drug: Drinking among Collegians=New Haven, Conn.: College and University Press, 1970. Pp. 479. $9.00 cloth; $4.50 paper; 1970. Page Count: 2. Issue Publication Date: May, 1972. 
AB  - Reviews the book, The Domesticated Drug: Drinking among Collegians edited by George L. Maddox (1970). This collection of articles--and its review--unfortunately has been a long time in getting to the reader. The volume is sponsored by the Society for the Study of Social Problems. A number of the articles present data on sociological (and other) characteristics of college drinkers and abstainers. The final section of the volume focuses on issues related to alcohol education on campuses and on the regulation of collegiate drinking behavior. Drinking among college students is likely to be very different when the full effect of these new national attitudes has been felt and when drug use patterns among young people have stabilized. This volume is of particular interest because it provides an excellent historical and conceptual summary of sociological and psychological work in the years prior to the period of major change which occurred in the latter half of the 196O's. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - collegiate drinking behavior
KW  - domesticated drugs
KW  - social problems
KW  - college drinkers
KW  - abstainers
KW  - 1972
KW  - College Students
KW  - Drinking Behavior
KW  - Drug Education
KW  - Social Issues
KW  - 1972
U2  - Maddox, George L. (Ed). (1970); The Domesticated Drug: Drinking among Collegians; New Haven, Conn.: College and University Press, 1970. Pp. 479. $9.00 cloth; $4.50 paper
DO  - 10.1037/0010927
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - ROBERT, MARJORIE S.
AU  - SMITH, R. GRAHAM
AU  - GALLO, ROBERT C.
AU  - SARIN, PREM S.
AU  - ABRELL, JOHN W.
T1  - Viral and Cellular DNA Polymerase: Comparison of Activities with Synthetic and Natural RNA Templates.
JO  - Science
JF  - Science
Y1  - 1972/05/19/
VL  - 176
IS  - 4036
M3  - Article
SP  - 798
EP  - 800
SN  - 00368075
AB  - Two DNA polymerases purified from normal human lymphocytes are distinguishable from the viral reverse transcriptases of avian myeloblastosis virus and Mason-Pfizer monkey virus by their relative affinity for select templates. In this respect, the activity of the two normal human lymphocyte polymerases closely resembles the activity of Escherichia coli DNA polymerase 1. The viral and cellular DNA polymerases are equally active with the nonspecific template, poly(rA) poly(dT). Criteria for distinguishing the activity of viral reverse transcriptase are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160285; ROBERT, MARJORIE S. 1; SMITH, R. GRAHAM 1; GALLO, ROBERT C. 1; SARIN, PREM S. 2; ABRELL, JOHN W. 2; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; 2: Bionetics Research Laboratories, Bethesda, Maryland 20014; Issue Info: 5/19/1972, Vol. 176 Issue 4036, p798; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HAYFLICK, LEONARD
AU  - PETRICCIANI, JOHN C.
AU  - Hopps, HOPE E.
AU  - LORENZ, DOUGLAS E.
T1  - Human Virus Vaccines: Why Monkey Cells?
JO  - Science
JF  - Science
Y1  - 1972/05/19/
VL  - 176
IS  - 4036
M3  - Article
SP  - 813
EP  - 814
SN  - 00368075
N1  - Accession Number: 85160293; HAYFLICK, LEONARD 1; PETRICCIANI, JOHN C. 2; Hopps, HOPE E. 2; LORENZ, DOUGLAS E. 2; Affiliations: 1: Stanford University School of Medicine, Stanford, California; 2: Laboratory of Pathology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/19/1972, Vol. 176 Issue 4036, p813; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Aptekar, R. G.;
AU  - Decker, J. L.;
AU  - Steinberg, A. D.;
T1  - Exacerbation of SLE nephritis after cyclophosphamide withdrawal
CT  - Exacerbation of SLE nephritis after cyclophosphamide withdrawal
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/05/25/
VL  - 286
IS  - May 25
SP  - 1159
EP  - 1160
SN  - 00284793
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 9-3564; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 2; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - It was suggested that caution be observed in withdrawing cyclophosphamide therapy in patients suffering from systemic lupus erythematosus (SLE) with nephritis. Two cases are cited in which adverse consequences followed cyclophosphamide withdrawal. Both patients died of uremia.
KW  - Cyclophosphamide--withdrawal-;
KW  - Drugs, adverse reactions--cyclophosphamide--withdrawal, fatal uremia, in systemic lupus erythematosus patients;
KW  - Antineoplastic agents--cyclophosphamide--withdrawal, adverse reactions, fatal uremia, in systemic lupus erythematosus patients;
KW  - Drug administration--cyclophosphamide--withdrawal, adverse reactions, fatal uremia, in systemic lupus erythematosus patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - GALANTER, MARC `
AU  - WYATT, RICHARD J.
AU  - LEMBERGER, Louis
AU  - WEINGARTNER, HERBERT
AU  - VAUGHAN, TOM B.
AU  - ROTH, WALTON T.
T1  - Effects on Humans of △9-Tetrahydrocannabinol Administered by Smoking.
JO  - Science
JF  - Science
Y1  - 1972/05/26/
VL  - 176
IS  - 4037
M3  - Article
SP  - 934
EP  - 936
SN  - 00368075
AB  - Twelve chronic marijuana users received △9-tetrahydrocannabinol by smoking. The magnitude of their pulse increment was highly correlated with their subjective experiences. Three! of the 12 subjects subsequently received △9z-tetrahydrocannabinol labeled with carbon-14; the time course of its concentration in plasma was highly correlated with the pulse increment. Subjective symptoms, however, appeared later and dissipated more slowly. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85160339; GALANTER, MARC ` 1; WYATT, RICHARD J. 1; LEMBERGER, Louis 1; WEINGARTNER, HERBERT 1; VAUGHAN, TOM B. 1; ROTH, WALTON T. 1; Affiliations: 1: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 5/26/1972, Vol. 176 Issue 4037, p934; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Sato, F. F.;
T1  - Trials with cyclophosphamide in SLE (systemic lupus erythematosus)
CT  - Trials with cyclophosphamide in SLE (systemic lupus erythematosus)
JO  - American Journal of Nursing (USA)
JF  - American Journal of Nursing (USA)
Y1  - 1972/06/01/
VL  - 72
IS  - Jun
SP  - 1077
EP  - 1079
SN  - 0002936X
AD  - Clinical Center, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 10-3292; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 5; Journal Coden: AJNUAK; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jimmie L. Hall
N2  - The nursing care of 2 systemic lupus erythematosus patients receiving cyclophosphamide in a trial study is described.
KW  - Cyclophosphamide--lupus erythematosus-;
KW  - Antineoplastic agents--cyclophosphamide--lupus erythematosus, therapy, nursing care, case reports;
KW  - Nursing--cyclophosphamide--lupus erythematosus, therapy, and care, case reports;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Neva, F. A.;
T1  - Parasitic diseases of the GI tract in the United States
CT  - Parasitic diseases of the GI tract in the United States
JO  - Dis. Mon.
JF  - Dis. Mon.
Y1  - 1972/06/01/
VL  - Pages 1-44
IS  - Jun
AD  - National Institutes of Health, Clinical Parasitology Section, Laboratory of Clinical Investigation of the Institute of Allergy and Infectious Disease, Bethesda, Maryland 20014
N1  - Accession Number: 10-1323; Language: English; References: 47; Journal Coden: DIMOAN; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: George D. Hurlow
N2  - The reproductive cycle of parasites presents the basis for chemotherapy in parasitic diseases. The parasitic diseases include amebiasis, giardiasis, schistosomiasis, strongyloidiasis, tapeworm, ascariasis, trichuriasis, hookworm, and enterobiasis. Dosage, specificity and combination chemotherapy is discussed for the following drugs: metronidazole, chloroquine, emetine, quinacrine, stibophen, antimony dimercaptosuccinate, niridazole, hycanthone, thiabendazole, niclosamide, piperazine, hexylresorcinol, tetrachlorethylene, bephenium hydroxynaphthoate, piperazine citrate and pyrvinium pamoate.
KW  - Anthelmintics--therapy--diseases, parasitic, GI tract, in humans;
KW  - Schistosomicides--therapy--discussion, in humans;
KW  - Dosage--anthelmintics--discussion, in humans;
KW  - Antiprotozoals--therapy--discussion, in humans;
KW  - Combined therapy--anthelmintics--discussion, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Carlson, Rae
T1  - Understanding Women: Implications for Personality Theory and Research.
JO  - Journal of Social Issues
JF  - Journal of Social Issues
Y1  - 1972/06//
VL  - 28
IS  - 2
M3  - Article
SP  - 17
EP  - 32
SN  - 00224537
AB  - Discusses the psychology of women.
KW  - FEMALES
KW  - PSYCHOLOGY
KW  - PERSONALITY
KW  - TYPOLOGY (Psychology)
KW  - FEMININITY
KW  - EMPIRICAL research
KW  - WOMEN
KW  - DECISION MAKING AND COMMUNICATIONS
N1  - Accession Number: 16486944; Carlson, Rae 1; Affiliations: 1 : National Institute of Mental Health.;  Source Info: Jun1972, Vol. 28 Issue 2, p17; Historical Period: 1972; Subject Term: FEMALES; Subject Term: PSYCHOLOGY; Subject Term: PERSONALITY; Subject Term: TYPOLOGY (Psychology); Subject Term: FEMININITY; Subject Term: EMPIRICAL research; Subject Term: WOMEN; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - FISCHINGER, P. J.
AU  - NOMURA, S.
AU  - PEEBLES, P. T.
AU  - HAAPALA, D. K.
AU  - BASSIN, R. H.
T1  - Reversion of Murine Sarcoma Virus Transformed Mouse Cells: Variants without a Rescuable Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1972/06/02/
VL  - 176
IS  - 4038
M3  - Article
SP  - 1033
EP  - 1035
SN  - 00368075
AB  - Murine sarcoma virus transformed mouse 3T3 cells, which are negative for murine leukemia virus and which yield sarcoma virus after superinfection with murine leukenmia viruts, spontaneously give rise to flat variants front which murine sarcoma virus can no longer be rescued. The revertants support leukemia virus growth and show an enhanced sensitivity to murine sarcoma superinfection and, like normal cells, do not release RNA-dependent DNA polymerase activity. Because revertants could be obtained with high frequency from progeny of single transformed cells, each cell that contains the sarcoma virus genome seems to have the capacity to suppress or elimtinate an RNA tumor virus native to its species of origin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158051; FISCHINGER, P. J. 1; NOMURA, S. 1; PEEBLES, P. T. 1; HAAPALA, D. K. 1; BASSIN, R. H. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/ 2/1972, Vol. 176 Issue 4038, p1033; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - NICOLL, ROGER A.
T1  - Gamma-Amiobutyric Acid: Role in Primary Afferent Depolarization.
JO  - Science
JF  - Science
Y1  - 1972/06/02/
VL  - 176
IS  - 4038
M3  - Article
SP  - 1043
EP  - 1045
SN  - 00368075
AB  - The effects of putative transmitters on the primary afferent terminals were studied in the magnesium-treated, isolated spinal cord of the frog. Gammaaminobutyric acid and glutamic acid reversibly depolarized primary afferent terminals and increased their excitability, whereas glycine produced weak and variable effects. Bicuculline and picrotoxin, which reduce primary afferent depolarization, reversibly antagonized the gamma-aminobutyric acid-mediated responses but had little effect on those produced by either glutamic acid or glycine. The glutamic acid- and the gamma-aminobutyric acid-induced depolarizations remained in the absence of external chloride but disappeared in the absence of external sodium. These results support the hypotheses that gamma-aminobutyric acid is the transmitter mediating the synaptic depolarization of primary afferent terminals and that sodium is the predominant ion involved. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158056; BARKER, JEFFERY L. 1; NICOLL, ROGER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 6/ 2/1972, Vol. 176 Issue 4038, p1043; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - RAPOPORT, STANLEY I.
AU  - BACHMAN, DAVID S.
AU  - THOMPSON, HARRY K.
T1  - Chronic Effects of Osmotic Opening of the Blood-Brain Barrier in the Monkey.
JO  - Science
JF  - Science
Y1  - 1972/06/16/
VL  - 176
IS  - 4040
M3  - Article
SP  - 1243
EP  - 1244
SN  - 00368075
AB  - In the monkey, the blood-brain barrier and the blood-aqueous and blood-vitreous barriers of the eye can be opened by internal carotid perfusion of solutions of 2 molar urea in a way compatible with survival and, in some few cases, without detectable neurological deficits. Urea presumably acts by osmotically shrinking the endothelial cells of the cerebrovascular vessels and opening their tight junctions. The high incidence of brain necrosis with neurological sequelae after perfusion of urea by the present technique precludes the use of osmotic opening of the blood-brain barrier for pharmacotherapy at this time. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87438410; RAPOPORT, STANLEY I. 1; BACHMAN, DAVID S. 2; THOMPSON, HARRY K. 3; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20-014; 2: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health; 3: Laboratory of Neurophysiology, National Institute of Mental Health; Issue Info: 6/16/1972, Vol. 176 Issue 4040, p1243; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cramer, H.;
AU  - Goodwin, F. K.;
AU  - Post, R. M.;
AU  - Bunney, W. E., Jr.;
T1  - Effects of probenecid and exercise on cerebrospinal fluid cyclic AMP in affective illness
CT  - Effects of probenecid and exercise on cerebrospinal fluid cyclic AMP in affective illness
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1972/06/17/
VL  - 1
IS  - Jun 17
SP  - 1346
EP  - 1347
SN  - 00237507
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 9-4475; Language: English; Chemical Name: Probenecid--57-66-9; Therapeutic Class: (40:40); AHFS Class: Uricosuric agents probenecid; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - Administration of probenecid by lumbar puncture to 16 manic and depressed patients resulted in increases in cyclic adenosine 3\PR/,5\PR/-monophosphate (AMP) levels.
KW  - Probenecid--effects-;
KW  - Uricosuric agents--probenecid--effects, increase, cyclic adenosine 3\PR/,5\PR/-monophosphate levels, in affectively ill patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - HIRSCHBERG, ERICH
AU  - JOSEPH FU, S. C.
AU  - FRISELL, WILHELM R.
AU  - FARBER, EMMANUEL
AU  - POTTER, VAN R.
AU  - RUSCH, HAROLD P.
AU  - SAFFIOTTI, UMBERTO
AU  - SHIMKIN, MICHAEL B.
AU  - BRENNAN, MICHAEL J.
AU  - NOWELL, PETER C.
AU  - CREECH, HUGH J.
AU  - TAYLOR, R. M.
AU  - SCHABEL JR., F. M.
AU  - FREI III, EMIL
AU  - LEPAGE, G. A.
AU  - WEINHOUSE, SIDNEY
AU  - HALL, THOMAS C.
T1  - Newsgathering.
JO  - Science
JF  - Science
Y1  - 1972/06/23/
VL  - 176
IS  - 4041
M3  - Article
SP  - 1288
EP  - 1289
SN  - 00368075
N1  - Accession Number: 85437480; HIRSCHBERG, ERICH 1; JOSEPH FU, S. C. 1; FRISELL, WILHELM R. 1; FARBER, EMMANUEL 2; POTTER, VAN R. 3; RUSCH, HAROLD P. 3; SAFFIOTTI, UMBERTO 4; SHIMKIN, MICHAEL B. 5; BRENNAN, MICHAEL J. 6; NOWELL, PETER C. 7; CREECH, HUGH J. 8; TAYLOR, R. M. 9; SCHABEL JR., F. M. 10; FREI III, EMIL 11; LEPAGE, G. A. 11; WEINHOUSE, SIDNEY 12; HALL, THOMAS C. 13; Affiliations: 1: College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103; 2: Temple University, Philadelphia, Pennsylvania 19122; 3: University of Wisconsin, Madison 53706; 4: National Cancer Institute, Bethesda, Maryland 20014; 5: University of California, San Diego, La Jolla 92037; 6: Michigan Cancer Foundation, Detroit 48201; 7: University of Pennsylvania, Philadelphia 19104; 8: Institute for Cancer Research, Philadelphia, Pennsylvania 19111; 9: National Cancer Institute of Canada, Toronto, Ontario; 10: Southern Research Institute, Birmingham, Alabama 35205; 11: M. D. Anderson Hospital, Houston, Texas 77025; 12: Fels Research Institute, Philadelphia, Pennsylvania 19140; 13: University of Rochester, Rochester, New York 14627; Issue Info: 6/23/1972, Vol. 176 Issue 4041, p1288; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - HOVEY, MARTIN M.
AU  - BAK, ANTHONY F.
AU  - CARPENTER, DAVID O.
T1  - Low Internal Conductivity of Aplysia Neuron Somata.
JO  - Science
JF  - Science
Y1  - 1972/06/23/
VL  - 176
IS  - 4041
M3  - Article
SP  - 1329
EP  - 1330
SN  - 00368075
AB  - The internal conductivity of Aplysia neuron somata was measured by passing constant current pulses across a calibrated four-electrode array. The intracellular medium -is less than one-tenth as conductive as seawater. The low conductivity probably results from structured cell water since ions are present in quantity and do not appear to be bound. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437502; HOVEY, MARTIN M. 1; BAK, ANTHONY F. 1; CARPENTER, DAVID O. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/23/1972, Vol. 176 Issue 4041, p1329; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - HOOKS, JOHN
AU  - GIBBS JR., C. J.
AU  - CHOPRA, H.
AU  - LEWIS, M.
AU  - GAJDUSEK, D. C.
T1  - Spontaneous Transformation of Human Brain Cells Grown in vitro and Description of Associated Virus Particles.
JO  - Science
JF  - Science
Y1  - 1972/06/30/
VL  - 176
IS  - 4042
M3  - Article
SP  - 1420
EP  - 1422
SN  - 00368075
AB  - A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158091; HOOKS, JOHN 1; GIBBS JR., C. J. 1; CHOPRA, H. 2; LEWIS, M. 1; GAJDUSEK, D. C. 1; Affiliations: 1: National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/30/1972, Vol. 176 Issue 4042, p1420; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LEVITAN, HERBERT
AU  - BARKER, JEFFERY L.
T1  - Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability.
JO  - Science
JF  - Science
Y1  - 1972/06/30/
VL  - 176
IS  - 4042
M3  - Article
SP  - 1423
EP  - 1425
SN  - 00368075
AB  - Salicylate atnd beuizoate., antd their anlalogs, reversibly intcrease the membrane potetntial and conductance of idenitified molluscan neurons by increasitng potassium conductance and decreasing chloride condluctanice. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficienits and their pK vallues. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85158092; LEVITAN, HERBERT 1; BARKER, JEFFERY L. 1; Affiliations: 1: Behavioral-Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 6/30/1972, Vol. 176 Issue 4042, p1423; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KONIVER, DEENA A.
AU  - WISWESSER, WILLIAM J.
AU  - USDIN, EARL
T1  - Wiswesser Line Notation: Simplified Techniques for Converting Chemical Structures to WLN.
JO  - Science
JF  - Science
Y1  - 1972/06/30/
VL  - 176
IS  - 4042
M3  - Article
SP  - 1437
EP  - 1439
SN  - 00368075
AB  - Techniques have been developed for the generation of Wiswesser Line Notations (WLN), which require knowledge neither of rules for manual conversion of structures to line notations nor of computer programmning. The desired WLN are obtained simply by drawing the structures of the compounds of interest on a tablet, which is linked to an appropriately programmned compuiter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158099; KONIVER, DEENA A. 1; WISWESSER, WILLIAM J. 2; USDIN, EARL 3; Affiliations: 1: Division of Cotnputer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014; 2: Vegetation Control Division, Edgewood Arsenal Chetnical Laboratory, Fort Detrick, Frederick, Maryland 21701; 3: Psychophartnacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852; Issue Info: 6/30/1972, Vol. 176 Issue 4042, p1437; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodwin, F. K.;
AU  - Murphy, D. L.;
AU  - Dunner, D. L.;
AU  - Bunney, W. E., Jr.;
T1  - Lithium response in unipolar versus bipolar depression
CT  - Lithium response in unipolar versus bipolar depression
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1972/07/01/
VL  - 129
IS  - Jul
SP  - 76
EP  - 79
SN  - 0002953X
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1265; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants lithium carbonate; References: 22; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Mary Ann Sullivan
N2  - The antidepressant effects of lithium carbonate were evaluated in a group of 52 depressed patients using a longitudinal double-blind design that involved alternating drug and placebo periods in the same patient. All patients were hospitalized on two 12-bed metabolic research units. Forty patients were assigned to the bipolar group and 12 to the unipolar group on the basis of presence (bipolar) or absence (unipolar) of a prior manic or hypomanic history. Lithium carbonate was administered in 300 mg. capsules for a duration of at least 2 weeks following a 6-day minimum placebo period. For the evaluation of response the mean depression ratings for the 4 days immediately prior to the administration of lithium were compared to the last 4 days on lithium. Of the 52 patients, 36 showed some improvement on lithium including 15 who had complete remission of symptoms. Virtually all of the antidepressant responses occurred in patients with a past history of mania or hypomania (the bipolar group).
KW  - Lithium carbonate--antidepressants-;
KW  - Antidepressants--lithium carbonate--evaluations, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - O'Brien, R. A.;
AU  - Boullin, D. J.;
T1  - Accumulation, storage and release of adrenergic neuron blocking agents and related drugs by human platelets
CT  - Accumulation, storage and release of adrenergic neuron blocking agents and related drugs by human platelets
JO  - Biochem. Pharmacol.
JF  - Biochem. Pharmacol.
Y1  - 1972/07/01/
VL  - 21
IS  - Jul 1
SP  - 1817
EP  - 1827
AD  - Laboratory of Pre-Clinical Pharmacology, National Institute of Mental Health, St. Elizabeth's Hospital, Washington, D. C. 20032
N1  - Accession Number: 9-4224; Language: English; Chemical Name: Guanethidine--55-65-2 Debrisoquin--1131-64-2 Amiloride--2609-46-3 Guanidine--113-00-8; Therapeutic Class: (40:28); AHFS Class: Diuretics amiloride (24:08); AHFS Class: Hypotensive agents guanethidine (24:08); AHFS Class: Hypotensive agents debrisoquin; References: 32; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: Douglas L. Thompson
N2  - Human platelets suspended in plasma or Krebs solution were incubated with radioactive guanethidine, debrisoquin, amiloride or guanidine and the platelet-bound radioactivity was measured. Guanethidine and debrisoquin were taken up by a saturable energy-dependent process inhibited by 5-hydroxytryptamine (5-HT), desipramine, amphetamine, cocaine and quinidine. Amiloride and guanidine entered by a nonsaturable mechanism not affected by metabolic inhibitors, 5-HT or drugs which interfere with the 5-HT transport process. It was suggested that guanethidine and debrisoquin probably utilize the 5-HT transport mechanism while amiloride and guanidine entered the cells by diffusion. It was concluded that although guanethidine and debrisoquin are taken up by platelets by an energy dependent system related to the 5-HT system, their storage sites are different. Amiloride enters platelets by diffusion and like guanethidine is firmly bound by the platelet, but not in the outer membrane. Storage of both drugs is largely intracellular involving more than one site, one of which may be the 5-HT stores.
KW  - Guanethidine--body distribution-;
KW  - Debrisoquin--body distribution-;
KW  - Amiloride--body distribution-;
KW  - Guanidine--body distribution-;
KW  - Binding--guanethidine--accumulation, storage and release, by human platelets;
KW  - Binding--debrisoquin--accumulation, storage and release, by human platelets;
KW  - Binding--amiloride--accumulation, storage and release, by human platelets;
KW  - Binding--guanidine--accumulation, storage and release, by human platelets;
KW  - Diuretics--amiloride--accumulation, storage and release, by human platelets;
KW  - Hypotensive agents--guanethidine--accumulation, storage and release, by human platelets;
KW  - Hypotensive agents--debrisoquin--accumulation, storage and release, by human platelets;
KW  - Metabolism--guanethidine--accumulation, storage and release, by human platelets;
KW  - Metabolism--debrisoquin--accumulation, storage and release, by human platelets;
KW  - Metabolism--amiloride--accumulation, storage and release, by human platelets;
KW  - Metabolism--guanidine--accumulation, storage and release, by human platelets;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Peters, C. J.
AU  - Johnson, K. M.
T1  - SERUM IMMUNOGLOBULIN LEVELS IN AUSTRALIA ANTIGEN POSITIVE AND AUSTRALIA ANTIGEN NEGATIVE HEPATITIS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1972/07//
VL  - 11
IS  - 3
M3  - Article
SP  - 381
EP  - 391
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Ig levels were determined by radial immunodiffusion in uncomplicated cases of acute hepatitis with or without Australia antigenaemia. Initial sera from Australia antigen negative cases showed a striking elevation in IgM levels when compared to Australia antigen positive cases (6.5 versus 1.9 mg/ml). None of twenty-four Australia antigen positive cases exceeded 3 mg/ml IgM, and only 3/58 Australia antigen negative cases exhibited values below 3 mg/ml. initial sera from Australia antigen positive and Australia antigen negative subjects did not differ in concentration of IgG, IgA, or IgD. Serial determinations of IgG revealed a transient fall in patients with Australia antigen positive hepatitis, and a rise in Australia antigen negative cases. Asymptomatic, Australia antigen positive, Guaymi Indian subjects were compared to matched Australia antigen negative controls from the same indigenous group and no differences in the concentration of IgG, IgM, IgA or IgD were found, although elevations of IgG and IgM were common in both groups. No evidence of abnormal proteins was found when sera were tested by cellulose acetate electrophoresis or by immunoelectrophoresis versus immunoglobulin-specific anti- sera. Ultracentrifugal analysis failed to detect `7S' IgM. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNODIFFUSION
KW  - ANTIGENS
KW  - IMMUNOGLOBULIN G
KW  - ANTIGEN-antibody reactions
KW  - IMMUNOELECTROPHORESIS
KW  - ELECTROPHORESIS
N1  - Accession Number: 14545001; Peters, C. J. 1 Johnson, K. M. 1; Affiliation:  1: U.S. Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Middle America Research Unit, Box 2011, Balboa Heights, Canal Zone, Central America.; Source Info: Jul72, Vol. 11 Issue 3, p381; Subject Term: IMMUNODIFFUSION; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULIN G; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOELECTROPHORESIS; Subject Term: ELECTROPHORESIS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Coe, J.E.
T1  - Immune Response in the Turtle (<em>Chrysemys picta</em>).
JO  - Immunology
JF  - Immunology
Y1  - 1972/07//
VL  - 23
IS  - 1
M3  - Article
SP  - 45
EP  - 52
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The immune response of painted turtles (Chrysemys picta) to four purified protein antigens was evaluated by radioimmunoelectrophoresis. Specific antibody production was consistently detected and antigen binding was related to four immunoglobulin (Ig) precipitin lines (called Igl, 2, 3, 4) in turtle serum. Antibody activity was detected first in the Ig1 or Ig2 and then later in the course of immunization in Ig3 and Ig4. Igl was about 19S in size, was not detectable after reduction and alkylation, and was the only Ig absent from turtle lymph. Ig3 and Ig4 were about 7S in size and Ig2 appeared slightly heavier by sucrose density gradient and Sephadex G-200 analysis. Haemagglutinins produced after primary inoculation were routinely sensitive to mild reduction and alkylation although antigen-binding capacity was still detectable. However, mercaptoethanol-resistant haemagglutinins were found in sera from turtles after booster injections of antigen. The electrophoretically slowest gamma globulin in turtle serum did not develop specific antigen binding capacity, but did bind Fe59 and presumably represents a transferrin-like protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - IMMUNOLOGY
KW  - CHRYSEMYS
KW  - TURTLES
KW  - ANTIGEN-antibody reactions
KW  - IMMUNOGLOBULINS
KW  - HEMAGGLUTININ
N1  - Accession Number: 13378221; Coe, J.E. 1; Affiliation:  1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Jul72, Vol. 23 Issue 1, p45; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: CHRYSEMYS; Subject Term: TURTLES; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOGLOBULINS; Subject Term: HEMAGGLUTININ; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112519 Other Aquaculture; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Whedon, C. Donald
T1  - MAGNITUDE OF PSORIASIS AS A DISEASE PROBLEM.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1972/07//
VL  - 59
IS  - 1
M3  - Article
SP  - 2
EP  - 2
SN  - 0022202X
AB  - This article focuses on a workshop on cell controls in psoriasis. There seems to be throughout the U.S. an increasing awareness of psoriasis and the feeling that there is a need to do more about it. This workshop is a significant and valuable part of an intensifying effort to learn more add to do more about this serious and important disease. The workshop will concentrate more closely on the fundamental aspects of cell biology and metabolism, hopefully eliciting information which will be the groundwork for future research leading to the control of this serious disease. Precise data on the current prevalence, disability and economic impact of psoriasis are not available.
KW  - PSORIASIS
KW  - CELL metabolism
KW  - CYTOLOGY
KW  - SKIN diseases
KW  - CELLS
KW  - UNITED States
N1  - Accession Number: 12625638; Whedon, C. Donald 1; Affiliation:  1: Director, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health.; Source Info: Jul72, Vol. 59 Issue 1, p2; Subject Term: PSORIASIS; Subject Term: CELL metabolism; Subject Term: CYTOLOGY; Subject Term: SKIN diseases; Subject Term: CELLS; Subject Term: UNITED States; Number of Pages: 1p; Document Type: Article
L3  - 10.1111/1523-1747.ep12625638
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nigra, Thomas P.
AU  - Friedland, Michael
AU  - Martin, George R.
T1  - CONTROLS OF CONNECTIVE TISSUE SYNTHESIS: COLLAGEN METABOLISM.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1972/07//
VL  - 59
IS  - 1
M3  - Article
SP  - 44
EP  - 48
SN  - 0022202X
AB  - To meet their structural role, connective tissues must be stable and resistant to stress. This stability has often been confused with metabolic inertness, but in fact synthetic and degradative processes in connective tissue can occur rapidly even in mature animals. In addition to a number of physiological stimuli that provoke the remodeling of these tissues, marked alterations occur in a variety of disease processes. Since collagen is the major structural component of connective tissue, authors have focused their attention on the changes occurring in its metabolism.
KW  - CONNECTIVE tissues
KW  - METABOLISM
KW  - MUSCULOSKELETAL system
KW  - COLLAGEN
KW  - DISEASES
KW  - PHYSIOLOGY
N1  - Accession Number: 12625755; Nigra, Thomas P. 1 Friedland, Michael 1 Martin, George R. 1; Affiliation:  1: Dermatology Branch, NCI and NIDR, National Institutes of Health, Bethesda, Maryland 20014.; Source Info: Jul72, Vol. 59 Issue 1, p44; Subject Term: CONNECTIVE tissues; Subject Term: METABOLISM; Subject Term: MUSCULOSKELETAL system; Subject Term: COLLAGEN; Subject Term: DISEASES; Subject Term: PHYSIOLOGY; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12625755
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DB  - aph
ER  - 

TY  - JOUR
AU  - Carter, Stephen K.
T1  - THE SEARCH FOR THERAPEUTIC CELL CONTROLS BY THE CHEMOTHERAPY PROGRAM OF THE NATIONAL CANCER INSTITUTE.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1972/07//
VL  - 59
IS  - 1
M3  - Article
SP  - 128
EP  - 138
SN  - 0022202X
AB  - The chemotherapy program of the National Cancer Institute functions in a major part as a drug development program. The program screens large numbers of compounds each year in a predominately <em>in vivo</em> screen utilizing mouse leukemia L1210 as its most important component. Input to the screen comes from the synthesis of cogeners of known active chemicals (rational base) and from heterogeneous classes of chemicals, uncharacterized antibiotics and plant products (empirical base). The determination of clinical activity and its correlation with the experimental screen depends significantly on an accepted definition of an adequate trial. The clinical trial of new drugs is divided into three phases and the chemotherapy program defines an adequate trial as the establishment of a maximally tolerated dose (phase I) and the evaluation on an adequate dosage schedule in at least six "signal" tumor types (phase II). As a minimum it would be unfair to label a drug as "inactive" until it has been adequately evaluated in at least 10-15 evaluable patients in the six signal tumor types(lung, breast, colon, acute lymphocytic and acute myelocytic leukemia and lymphosarcoma) and found to have insufficient clinical activity in all of them. Defining an adequate trial has to take into account the question of whether an adequate dosage schedule was used. The chemotherapy program has a defined protocol for schedule dependency testing of all of its drugs in experimental systems and in this way attempts to define which schedule might be optimal for usage in men. The positive correlation for such an approach has been shown with drugs such as methotrexate and arabinosyl cytosine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER treatment
KW  - DRUG therapy
KW  - DRUG development
KW  - PHARMACOLOGY
KW  - LEUKEMIA
KW  - ANTIBIOTICS
N1  - Accession Number: 12625903; Carter, Stephen K. 1,2; Affiliation:  1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014.  2: Chief, Cancer Therapy Evaluation Branch, National Cancer Institute.; Source Info: Jul72, Vol. 59 Issue 1, p128; Subject Term: CANCER treatment; Subject Term: DRUG therapy; Subject Term: DRUG development; Subject Term: PHARMACOLOGY; Subject Term: LEUKEMIA; Subject Term: ANTIBIOTICS; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1523-1747.ep12625903
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kattwinkel, J.;
AU  - Agus, S. G.;
AU  - Taussig, L. M.;
AU  - di Sant'Agnese, P. A.;
AU  - Laster, L.;
T1  - Use of L-arginine and sodium bicarbonate in the treatment of malabsorption due to cystic fibrosis
CT  - Use of L-arginine and sodium bicarbonate in the treatment of malabsorption due to cystic fibrosis
JO  - Pediatrics (USA)
JF  - Pediatrics (USA)
Y1  - 1972/07/01/
VL  - 50
IS  - Jul
SP  - 133
EP  - 137
SN  - 00314005
AD  - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-2198; Language: English; Trade Name: Cotazyme; Generic Name: Pancrelipase; Chemical Name: Pancrelipase--9001-62-1 Arginine--74-79-3 Sodium bicarbonate--144-55-8; Therapeutic Class: (44:00); AHFS Class: Enzymes pancrelipase; References: 16; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Brenda Sue Martinez
N2  - Intestinal malabsorption due to cystic fibrosis was treated with pancrelipase (Cotazyme), with and without sodium bicarbonate, and with arginine in 10 hospitalized patients serving as their own controls. All of the patients received a 100 g. fat diet and multivitamins and 6 of the 10 patients were taking antibiotics. Stools were collected in 72 hour pools and 2 or 3 pools were obtained during each regimen. The only significant reduction of stool weight, fat and nitrogen was found with Cotazym alone or with sodium bicarbonate. There was a significant loss of weight during arginine administration, in contrast to the weight gain seen with the other regimens.
KW  - Pancrelipase--alone and with sodium bicarbonate-;
KW  - Arginine--cystic fibrosis-;
KW  - Sodium bicarbonate--combination, pancrelipase-;
KW  - Cystic fibrosis--malabsorption--intestinal, therapy, comparison of pancrelipase alone and with sodium bicarbonate and arginine, in patients;
KW  - Amino acids--arginine--cystic fibrosis, therapy of intestinal malabsorption compared to pancrelipase alone and with sodium bicarbonate, in patients;
KW  - Enzymes--pancrelipase--alone and with sodium bicarbonate, comparison to arginine, in intestinal malabsorption due to cystic fibrosis, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Frandsen, Asger M.
AU  - Barbano, Joseph P.
AU  - Suomi, John D.
AU  - Chang, Jaqueline J.
AU  - Houston, Robert
T1  - A comparison of the effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1972/07//
VL  - 80
IS  - 4
M3  - Article
SP  - 267
EP  - 271
SN  - 0029845X
AB  - The effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque was studied in 182 college students. At an initial screening examination, plaque was assessed using the gingival index. These plaque scores were used to divide the group into those with poor and those with good oral cleanliness. Within each of the two groups, the subjects were randomly assigned to a toothbrushing method and to one of three instructors. Then the participants had their teeth cleaned and were asked to abstain from toothbrushing for one week. After this period of plaque accumulation the participants were again scored for plaque. The test subjects were carefully instructed in the particular tooth-brushing method they were to use and the controls were asked to resume their usual methods. One week later the participants were again examined for plaque. An interaction between toothbrushing method and instructor was found indicating that the effectiveness of a particular method depended in pan on. the instructor. Nevertheless, the CHARTERS' and scrub methods of brushing appeared to be more effective in removing plaque. Generally, subjects with cleaner teeth prior to the stu achieved grater plaque reductions than those with initially poor oral cleanliness. All methods of bruching were relatively ineffective in removing proximal plaque. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOOTHBRUSHES
KW  - DENTAL plaque
KW  - ORAL hygiene products
KW  - DENTAL deposits
KW  - GINGIVAL fluid
KW  - DENTAL care
N1  - Accession Number: 13235069; Frandsen, Asger M. 1 Barbano, Joseph P. 2 Suomi, John D. 2 Chang, Jaqueline J. 2 Houston, Robert 3; Affiliation:  1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark.  2: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland and San Francisco, California.  3: Department ot Health, Oregon State University, Corvallis, Oregon, U.S.A.; Source Info: 1972, Vol. 80 Issue 4, p267; Subject Term: TOOTHBRUSHES; Subject Term: DENTAL plaque; Subject Term: ORAL hygiene products; Subject Term: DENTAL deposits; Subject Term: GINGIVAL fluid; Subject Term: DENTAL care; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 339994 Broom, Brush, and Mop Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - WHITMIRE, CARRIE E.
AU  - HUEBNER, ROBERT J.
T1  - Inhibition of Chemical Carcinogenesis by Viral Vaccines.
JO  - Science
JF  - Science
Y1  - 1972/07/07/
VL  - 177
IS  - 4043
M3  - Article
SP  - 60
EP  - 61
SN  - 00368075
AB  - The incidence of 3-methylcholanthrene-induced subcutaneous tumors was significantly reduced by a single injection of inactivated type C -RNA viral vaccine. Rauscher leukemnia virus vaccine reduced the incidence of sarcomas from 78 to 50 percent in the BALB/cCr mouse. Radiation leukemia virus vaccine and a vaccine from a wild murine leukemia virus derived from a 3-methylcholanthrene tumor reduced the incidence of sarcoma from 86 percent to 33 and 37 percents, respectively, in the C57BL/6 mouse. These reductions in tumor incidence by virus vaccines help support the concept that type C RNA viruses serve as determinants of chemically induced cancer; additional studies of vaccines made with more purified virus preparations are necessary. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158128; WHITMIRE, CARRIE E. 1; HUEBNER, ROBERT J. 2; Affiliations: 1: Department of Viral-Chemical Oncology, Microbiological Associates, Inc., 4733 Bethesda Avenue, Bethesda, Maryland 20014; 2: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/ 7/1972, Vol. 177 Issue 4043, p60; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WATERS, TOMMY D.
AU  - ANDERSON JR., PAUL S.
AU  - BEEBE, GILBERT W.
AU  - MILLER, ROBERT W.
T1  - Yellow Fever Vaccination, Avian Leukosis Virus, and Cancer Risk in Man.
JO  - Science
JF  - Science
Y1  - 1972/07/07/
VL  - 177
IS  - 4043
M3  - Article
SP  - 76
EP  - 77
SN  - 00368075
AB  - Comparison was made between 2659 veterans who died of cancer, during 1950 to 1954 or 1959 to 1963, and matched controls, based on the frequency of yellow fever immunization during World War 11. The vaccine was produced from chick embryos that almost certainly contained avian leukosissarcoma viruses. Among the veterans, no relation was found between vaccination and leukemia, lymphoma, or other cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158136; WATERS, TOMMY D. 1; ANDERSON JR., PAUL S. 1; BEEBE, GILBERT W. 2; MILLER, ROBERT W. 3; Affiliations: 1: School of Public Health, University of Oklahonia Medical Center, Oklahoma City 73104; 2: National Academy of Sciences- National Research Council, Washington, D.C. 20418; 3: Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/ 7/1972, Vol. 177 Issue 4043, p76; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHNITZER, BERTRAM
AU  - SODEMAN, THOMAS
AU  - MEAD, MICHAEL L.
AU  - CONTACOS, PETER G.
T1  - Pitting Function of the Spleen in Malaria: Ultrastructural Observations.
JO  - Science
JF  - Science
Y1  - 1972/07/14/
VL  - 177
IS  - 4044
M3  - Article
SP  - 175
EP  - 177
SN  - 00368075
AB  - Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158169; SCHNITZER, BERTRAM 1; SODEMAN, THOMAS 1; MEAD, MICHAEL L. 1; CONTACOS, PETER G. 2; Affiliations: 1: Department of Pathology, University of Michigan, Ann Arbor, 48104; 2: Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institutes of Health, Chamnblee, Georgia, 30341; Issue Info: 7/14/1972, Vol. 177 Issue 4044, p175; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GOURAS, PETER
AU  - BISHOP, PETER O.
T1  - Neural Basis of Vision.
JO  - Science
JF  - Science
Y1  - 1972/07/14/
VL  - 177
IS  - 4044
M3  - Article
SP  - 188
EP  - 189
SN  - 00368075
N1  - Accession Number: 85158176; GOURAS, PETER 1; BISHOP, PETER O. 2; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20014; 2: John Curtin School of Medical Research, Canberra City, A.C.T., 2601, Australia; Issue Info: 7/14/1972, Vol. 177 Issue 4044, p188; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KWON-CHUNG, K. J.
T1  - Emmonsiella capsulata: Perfect State of Histoplasma capsulatum.
JO  - Science
JF  - Science
Y1  - 1972/07/28/
VL  - 177
IS  - 4046
M3  - Article
SP  - 368
EP  - 369
SN  - 00368075
N1  - Accession Number: 85437551; KWON-CHUNG, K. J. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20041; Issue Info: 7/28/1972, Vol. 177 Issue 4046, p368; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Sullivan, P. D.
AU  - Christine, Barbara
AU  - Connelly, Roger
AU  - Barrett, Harold
T1  - Analysis of Trends in Age-Adjusted Incidence Rates for 10 Major Sites of Cancer.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1972/08//
VL  - 62
IS  - 8
M3  - Article
SP  - 1065
EP  - 1071
PB  - American Public Health Association
SN  - 00900036
AB  - Based on data from the Connecticut Tumor Registry this report offers trends for the incidence of cancer over a period of thirty years (1935-1965). Findings are reported and a comparison is made of the Connecticut data with that from Alameda County, California. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epidemiology
KW  - Public health
KW  - Tumors
KW  - Lungs -- Cancer
KW  - Breast cancer
KW  - Diseases -- Risk factors
KW  - Regression analysis
KW  - Mortality
N1  - Accession Number: 24294231; Sullivan, P. D. 1; Christine, Barbara 2; Connelly, Roger 3; Barrett, Harold 4; Affiliations: 1: Statistician, Connecticut State Department of Health; 2: Director, Connecticut Tumor Registry, Connecticut State Department of Health; 3: Biostatistician, Biometry Branch, National Cancer Institute; 4: Deputy Commissioner, Connecticut State Department of Health, 79 Elm St., Hartford, Connecticut, 06115; Issue Info: Aug1972, Vol. 62 Issue 8, p1065; Thesaurus Term: Epidemiology; Thesaurus Term: Public health; Subject Term: Tumors; Subject Term: Lungs -- Cancer; Subject Term: Breast cancer; Subject Term: Diseases -- Risk factors; Subject Term: Regression analysis; Subject Term: Mortality; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Prien, R. F.;
AU  - Caffey, E. M.;
AU  - Klett, C. J.;
T1  - Comparison of lithium carbonate and chlorpromazine in the treatment of excited schizo-affectives
CT  - Comparison of lithium carbonate and chlorpromazine in the treatment of excited schizo-affectives
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1972/08/01/
VL  - 27
IS  - Aug
SP  - 182
EP  - 189
AD  - Veterans Administration and National Institute of Mental Health Collaborative Study Group, Central Neuropsychiatric Research Laboratory, V A Hospital, Perry Point, Maryland 21902
N1  - Accession Number: 12-3713; Language: English; Trade Name: Thorazine; Generic Name: Chlorpromazine; Chemical Name: Lithium carbonate--554-13-2 Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine, comparison, lithium carbonate (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate, comparison, chlorpromazine; References: 39; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Eighty-three hospitalized patients with a diagnosis of schizo-affective psychosis, excited state, received lithium carbonate 500 to 3000 mg/day or chlorpromazine hydrochloride (Thorazine) 200 to 3000 mg/day for 3 weeks in a double-blind controlled study. There were 59 male and 24 female patients, ages 19 to 60 years, who were classified as highly active or mildly active. The highly active patients responded more favorably to chlorpromazine than to lithium, whereas mildly active psychotics received similar benefit with either agent. The drop-out rate for the 2 treatment groups was 11% for the chlorpromazine group and 22% for the other due to poor response or toxicity; an additional 7% of the former and 14% of the latter terminated treatment because of development or intercurrent illness. Serum lithium levels ranged from 0.6 to 2.0 meq/l with a median level of 1.0 and 1.3 meq/l for the mildly active group and highly active group, respectively. The most prevalent side effects to chlorpromazine were somnolence, constipation and dry mouth, and to lithium were tremor, dry mouth, hyperactive deep tendon reflexes and transient gastric discomfort.
KW  - Lithium carbonate--comparison, chlorpromazine-;
KW  - Chlorpromazine--comparison, lithium carbonate-;
KW  - Tranquilizers--chlorpromazine, comparison, lithium carbonate--chlorpromazine, schizo-affective, therapy, in patients;
KW  - Psychotherapeutic agents--lithium carbonate, comparison, chlorpromazine--psychoses, schizo-affective, therapy in patients;
KW  - Blood levels--lithium carbonate--psychoses, therapy, in patients;
KW  - Metabolism--lithium carbonate--blood levels, psychoses therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - ABST
AU  - Robbins, J. H.
AU  - Gart, J. J.
AU  - Levis, W. R.
AU  - Burk, P. G.
T1  - THE MILLIPORE FILTER ASSAY TECHNIQUE FOR MEASURING TRITIATED THYMIDINE INCORPORATION INTO DNA IN LEUCOCYTE CULTURES.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1972/08//
VL  - 11
IS  - 4
M3  - Abstract
SP  - 629
EP  - 640
PB  - Wiley-Blackwell
SN  - 00099104
AB  - In this paper we present in detail the very rapid and sensitive Millipore filter assay technique for measuring tritiated thymidine incorporation during semiconservativé DNA synthesis in human peripheral blood leucocyte cultures. Leucocytes which have been incubated with tritiated thymidine are trapped on a Millipore filter which is then suitably washed and dried. The filter is then immersed in scintillation fluid in a double-vial apparatus designed to ensure a reproducible counting geometry. Alternatively, the filter and its radioactive contents can be combusted to tritiated water, the radioactivity of which is then determined in a homogeneous counting system. The parameters related to the Miilipore filter assay technique are presented, and its present uses and general applicability discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYMIDINE
KW  - DNA
KW  - LEUCOCYTES
KW  - CELL culture
KW  - RADIOACTIVITY
KW  - BLOOD cells
N1  - Accession Number: 14572813; Robbins, J. H. 1 Gart, J. J. 1 Levis, W. R. 1 Burk, P. G. 1; Affiliation:  1: National Cancer Institute, National Institutes of Health, U.S.A.; Source Info: Aug72, Vol. 11 Issue 4, p629; Subject Term: THYMIDINE; Subject Term: DNA; Subject Term: LEUCOCYTES; Subject Term: CELL culture; Subject Term: RADIOACTIVITY; Subject Term: BLOOD cells; Number of Pages: 12p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BLOOM, F. E.
AU  - HOFFER, B. J.
AU  - BATTENBERG, E. R.
AU  - SIGGINS, G. R.
AU  - STEINER, A. L.
AU  - PARKER, C. W.
AU  - WEDNER, H. J.
T1  - Adenosine 3',5'-Monophosphate Is Localized in Cerebellar Neurons: Immunofluorescence Evidence.
JO  - Science
JF  - Science
Y1  - 1972/08/04/
VL  - 177
IS  - 4047
M3  - Article
SP  - 436
EP  - 438
SN  - 00368075
AB  - Adenosine 3',5'-monophosphate is localized in specific cerebellar neurons, as shown by fluorescence immunocytochemistry with a specific rabbit immunoglobulin. Positive staining is exhibited by Purkinje neurons and granule cells. The increase in concentration of cyclic adenosine monophosphate in the cerebellum, which is known to follow decapitation, is represented by greatly increased fluorescence of Purkinje neurons only. These immunofluorescence data provide the first evidence for localization of cyclic adenosine monophosphate in specific neurons and may permit further exploration into the role of this cyclic nucleotide in neuronal function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85362850; BLOOM, F. E. 1; HOFFER, B. J. 1; BATTENBERG, E. R. 1; SIGGINS, G. R. 1; STEINER, A. L. 2; PARKER, C. W. 3; WEDNER, H. J. 3; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Medicine, Albany Medical College, Albany, New York; 3: Division of Immunology, Department of Medicine, Washington University Medical School, Saint Louis, Missouri 63110; Issue Info: 8/ 4/1972, Vol. 177 Issue 4047, p436; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Duttera, M. J.;
AU  - Carolla, R. L.;
AU  - Gallelli, J. F.;
AU  - Gullion, D. S.;
AU  - Keim, D. E.;
AU  - \ET/;
T1  - Hematuria and crystalluria after high-dose 6-mercaptopurine administration
CT  - Hematuria and crystalluria after high-dose 6-mercaptopurine administration
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/08/10/
VL  - 287
IS  - Aug 10
SP  - 292
EP  - 294
SN  - 00284793
AD  - Building 10, Room 6B15, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-0224; Language: English; Chemical Name: Mercaptopurine--6112-76-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mercaptopurine; References: 8; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - Nine children with acute leukemia experienced hematuria and crystalluria in association with high-dosage I.V. mercaptopurine administration. It was concluded that I.V. doses exceeding 750 mg./m.\SU/2\BS/ can produce toxic effects and that doses in excess of 500 mg./m.\SU/2\BS/ should only be given to patients who have not responded to lower dosages.
KW  - Mercaptopurine--toxicity-;
KW  - Toxicity--mercaptopurine--hematuria and crystalluria, following high dosage injections, in leukemic children;
KW  - Antineoplastic agents--mercaptopurine--toxicity, hematuria and crystalluria, following high dosage injections, in leukemic children;
KW  - Dosage--mercaptopurine--injections, high, toxicity, hematuria and crystalluria, in leukemic children;
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ER  - 

TY  - JOUR
AU  - KLEIN, DAVID C.
AU  - WELLER, JOAN L.
T1  - Rapid Light-Induced Decrease in Pineal Serotonin N-Acetyltransferase Activity.
JO  - Science
JF  - Science
Y1  - 1972/08/11/
VL  - 177
IS  - 4048
M3  - Article
SP  - 532
EP  - 533
SN  - 00368075
AB  - Light acting by way of the eye causes the dark-induced activity of serotonin N-acetyltransferase in the pineal gland of the rat to decrease with a halving time of about 3 minutes. This effect, which is one of the more rapid physiological changes known to occur in the activity of any enzyme that metabolizes biogenic amines, appears to explain the rapid increase in the concentration of pineal serotonin that is caused by light exposure at night. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85116833; KLEIN, DAVID C. 1; WELLER, JOAN L. 1; Affiliations: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 8/11/1972, Vol. 177 Issue 4048, p532; Number of Pages: 2p; Document Type: Article
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TY  - JOUR
AU  - STETTEN JR., DEWITT
T1  - Research and Planning.
JO  - Science
JF  - Science
Y1  - 1972/08/18/
VL  - 177
IS  - 4049
M3  - Article
SP  - 563
EP  - 563
SN  - 00368075
N1  - Accession Number: 85116841; STETTEN JR., DEWITT 1; Affiliations: 1: Director, National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 8/18/1972, Vol. 177 Issue 4049, following p563; Number of Pages: 2/3p; Document Type: Article
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TY  - JOUR
AU  - WHITLOCK JR., JAMES P.
AU  - COOPER, HERBERT L.
AU  - GELBOIN, HARRY V.
T1  - Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]lanthracene.
JO  - Science
JF  - Science
Y1  - 1972/08/18/
VL  - 177
IS  - 4049
M3  - Article
SP  - 618
EP  - 619
SN  - 00368075
AB  - A mixed-function oxidase that requires reduced nicotinamide adenine dinucleotide phosphate, is carbon monoxide sensitive, and is drug-metabolizing is present in human lymphocytes and is increased to different levels by treatment with phytohemagglutinin, pokeweed mitogen, and a polycyclic hydrocarbon. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85116866; WHITLOCK JR., JAMES P. 1; COOPER, HERBERT L. 2; GELBOIN, HARRY V. 3; Affiliations: 1: Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Cell Biology Section, Laboratory of Biochemistry, National Institute of Dental Research, Bethesda, Maryland; 3: Chemistry Branch, National Cancer Institute, Bethesda, Maryland; Issue Info: 8/18/1972, Vol. 177 Issue 4049, p618; Number of Pages: 2p; Document Type: Article
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TY  - JOUR
AU  - FORMAN, DAVID S.
AU  - LEDEEN, ROBERT W.
T1  - Axonal Transport of Gangliosides in the Goldfish Optic Nerve.
JO  - Science
JF  - Science
Y1  - 1972/08/18/
VL  - 177
IS  - 4049
M3  - Article
SP  - 630
EP  - 633
SN  - 00368075
AB  - Radioactive glucosamine and N-acetylmannosamine injected into the goldfish eye are incorporated into gangliosides that undergo rapid axonal transport to the optic nerve terminals. All ganglioside fractions are labeled. These data provide the first evidence that axonal transport has a role in neuronal ganglioside function and metabolism. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85116872; FORMAN, DAVID S. 1; LEDEEN, ROBERT W. 2; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Departments of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461; Issue Info: 8/18/1972, Vol. 177 Issue 4049, p630; Number of Pages: 4p; Document Type: Article
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TY  - JOUR
AU  - COSTELL, RONALD M.
AU  - LUNDE, DONALD T.
AU  - KOPELL, BERT S.
AU  - WITTNER, WILLIAM K.
T1  - Contingent Negative Variation as an Indicator of Sexual Object Preference.
JO  - Science
JF  - Science
Y1  - 1972/08/25/
VL  - 177
IS  - 4050
M3  - Article
SP  - 718
EP  - 720
SN  - 00368075
AB  - The contingent negative variation (CNV) was recorded in the interval between paired visual exposures of male nudes, female nudes, and sexually "neutral" silhouettes. Groups of 12 male and 12 female subjects viewing 50 randomized presentations from each stinmulus category responded with averaged CNV amplitudes proportional to the predicted degree of sexual interest in the stimulus classes. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87428660; COSTELL, RONALD M. 1; LUNDE, DONALD T. 2; KOPELL, BERT S. 2; WITTNER, WILLIAM K. 2; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305; Issue Info: 8/25/1972, Vol. 177 Issue 4050, p718; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
TY  - GEN
AU  - Feldman, D. B.;
AU  - Rall, D. P.;
AU  - Moore, J. A.;
T1  - Dry detergent and soap effects on the rabbit eye
CT  - Dry detergent and soap effects on the rabbit eye
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1972/08/28/
VL  - 221
IS  - Aug 28
SP  - 1055
AD  - National Institutes of Health, Research Triangle Park, North Carolina
N1  - Accession Number: 10-0022; Language: English; References: 2; Publication Type: Letters; Journal Coden: JAMAAP; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - Laundry products containing soap powder, phosphate, carbonate or metasilicate, and dishwasher products containing phosphate or metasilicate were tested in order to determine the degree of toxicity to eyes of rabbits. Tables listing results are included. With laundry products, soap powder was the least damaging to the cornea and adjacent structures. Ocular reaction to phosphate detergents persisted longer than soap. The reaction to carbonate and metasilicate detergents was more intense than in the first 2 products. With the dishwasher products, corneal toxicity was more severe with the metasilicate detergent.
KW  - Soaps--laundry--toxicity, effects, on rabbit eyes, compared to phosphate, carbonate and metasilicate containing products;
KW  - Toxicity--soaps--laundry, effects, on rabbit eyes, compared to phosphate, carbonate and metasilicate containing products;
KW  - Detergents--toxicity--effects, on rabbit eyes, comparison of phosphate, carbonate, and metasilicate containing products to soap;
KW  - Toxicity--detergents--effects, on rabbit eyes, comparison of phosphate, carbonate, and metasilicate containing products to soap;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Gralnick, H. R.;
AU  - McGinniss, M.;
AU  - Halterman, R.;
T1  - Thrombocytopenia with sodium cephalothin therapy
CT  - Thrombocytopenia with sodium cephalothin therapy
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/09/01/
VL  - 77
IS  - Sep
SP  - 401
EP  - 404
SN  - 00034819
AD  - Hematology Service, Clinical Center, Building 10, Room 5N-236, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1433; Language: English; Chemical Name: Cephalothin--153-61-7; Therapeutic Class: (8:12); AHFS Class: Antibiotics cephalothin; References: 8; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Judith A. Kepler
N2  - Thrombocytopenia occurred on 2 separate occasions in a patient while she was receiving sodium cephalothin. In vitro and in vivo studies with cephalothin showed nonspecific protein binding to platelets and a specific anticephalothin antibody that resulted in platelet agglutination in vitro and shortened platelet survival and thrombocytopenia in vivo.
KW  - Cephalothin--sodium-;
KW  - Drugs, adverse reactions--cephalothin--sodium, thrombocytopenia, in patient;
KW  - Antibiotics--cephalothin--sodium, adverse reactions, thrombocytopenia, in patient;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Bunney, W. E., Jr.;
AU  - Goodwin, F. K.;
AU  - Murphy, D. L.;
T1  - Switch process in manic-depressive illness
CT  - Switch process in manic-depressive illness
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1972/09/01/
VL  - 27
IS  - Sep
SP  - 312
EP  - 317
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 11-0514; Language: English; Trade Name: Eskalith--Lithane--Lithonate; Generic Name: Lithium carbonate; Lithium carbonate; Lithium carbonate; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 47; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - The biological theories concerning manic-depressive illness, the psychobiological factors and proposed genetic abnormality involved with the manic-depressive switch process and the mechanisms of action of lithium carbonate (Eskalith, Lithane, Lithonate) are reviewed. The biochemical interaction of endogenous electrolytes, norepinephrine, lithium and a transport carrier is also considered.
KW  - Lithium carbonate--psychoses-;
KW  - Psychotherapeutic agents--lithium carbonate--psychoses, manic depressive, therapy, in patients;
KW  - Mechanism of action--lithium carbonate--psychoses, manic depressive, therapy, in patients;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Weiss, J. L.;
AU  - Watanabe, A. M.;
AU  - Lemberger, L.;
AU  - Tamarkin, N. R.;
AU  - Cardon, P. V.;
T1  - Cardiovascular effects of delta-9-tetrahydrocannabinol in man
CT  - Cardiovascular effects of delta-9-tetrahydrocannabinol in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1972/09/01/
VL  - 13
IS  - Sep-Oct
SP  - 671
EP  - 684
SN  - 00099236
AD  - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1782; Language: English; References: 31; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2  - The effects of 0.3 mg./kg. oral tetrahydrocannabinol on the circulatory system was investigated in 8 male cannabis users. Recumbent and upright heart rate, recumbent mean arterial blood pressure, forearm blood flow, and calculated forearm conductance all increased significantly following drug administration. Significant shortening of ventricular pre-ejection period and attenuation or abolition of reflex venoconstriction in response to a deep breath were also seen. Mean arterial pressure decreased transiently with head-up tilt and was associated with presyncope in 7 subjects, although cardioacceleratory response and forearm arteriolar constriction remained intact. Plasma levels of labeled THC and its metabolites were maximal at 3 hours. Gastrointestinal absorption was 95% complete. Urinary excretion of free epinephrine was significantly higher during the 6 hour period following \TR/-9-THC administration than during a similar control period. Free norepinephrine excretion was unchanged. Several of the cardiovascular effects seen appear to be consistent with increased sympathoadrenal activity. This suggests the possibility that augmented epinephrine secretion is in part responsible for these circulatory changes.
KW  - Tetrahydrocannabinol--oral-;
KW  - Blood levels--tetrahydrocannabinol--oral, in males;
KW  - Absorption--tetrahydrocannabinol--oral, in males;
KW  - Metabolism--tetrahydrocannabinol--oral, in males;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Canellos, G. P.;
AU  - Young, R. C.;
AU  - DeVita, V. T.;
T1  - Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy
CT  - Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1972/09/01/
VL  - 13
IS  - Sep-Oct
SP  - 750
EP  - 754
SN  - 00099236
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 10-2186; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Prednisone--53-03-2 Procarbazine--671-16-9; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Twenty one patients with Hodgkin's disease who were in relapse following extensive radiation therapy were treated with a combination chemotherapy program, which included nitrogen mustard (mechlorethamine), vincristine, prednisone, and procarbazine for 6 monthly cycles. Sixteen patients (76%) achieved complete remission. In a comparable group of patients with extensive disease but no previous radiotherapy the over-all remission rate and the degree of myelosuppression were similar. The interval between the end of radiotherapy and the onset of chemotherapy did not correlate with the extent of subsequent drug toxicity. Relapse of Hodgkin's disease in the patients following intensive radiotherapy with curative intent does not preclude a subsequent excellent response to combination chemotherapy and a prolonged disease-free interval.
KW  - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW  - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW  - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW  - Procarbazine--prednisone, mechlorethamine and vincristine-;
KW  - Antineoplastic agents--combined therapy--Hodgkin's disease, in patients;
KW  - Combined therapy--vincristine, procarbazine and prednisone--Hodgkin's disease, in patients;
KW  - Combined therapy--procarbazine, prednisone and vincristine--Hodgkin's disease, in patients;
KW  - Combined therapy--prednisone, procarbazine and vincristine--Hodgkin's disease, in patients;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Chez, R. A.;
T1  - Role of the pharmacist in family planning: a Pennsylvania survey
CT  - Role of the pharmacist in family planning: a Pennsylvania survey
JO  - J. Am. Pharm. Assoc.
JF  - J. Am. Pharm. Assoc.
Y1  - 1972/09/01/
VL  - NS12
IS  - Sep
SP  - 464
EP  - 466
AD  - Pregnancy Research Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-3541; Language: English; Journal Coden: JPHAA3; Section Heading: Pharmacy Practice; Abstract Author: Drucella Andersen
N2  - This survey reflects pharmacists' attitudes regarding the sale and display of contraceptives. A total of 1,490 questionnaires were mailed to members of the Pennsylvania Pharmaceutical Association. A 52% response was obtained within a 3 month period after a single mailing. There was no preliminary notification nor an attempt at follow-up. Specifically, there was a marked difference in the types of contraceptives displayed, with foams, creams, and jellies 8 times more frequently displayed than condoms. The question concerning sales to unmarried minors was answered affirmatively by over 33% of the respondents, with religion and age being a significant factor in the negative respondents. It was also ascertained that the pharmacist was rarely asked for contraceptive advice from men and women patrons.
KW  - Pharmacists, community--contraceptives--display, and sales, attitudes, survey;
KW  - Sociology--pharmacists, community--contraceptives, sale and display, survey of attitudes;
KW  - Contraceptives--advertising--display, and sale, pharmacists attitudes;
KW  - Marketing--contraceptives--pharmacists, community, attitudes surveyed regarding display and sale;
KW  - Information--contraceptives--pharmacists, community, rarely asked for advice;
KW  - Community service--contraceptives--advertising, and display, pharmacists attitudes;
KW  - Advertising--contraceptives--pharmacy, community, attitudes, survey;
KW  - Patient information--consultation--contraceptives, survey, pharmacists attitudes;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Christian, D. G.;
AU  - Cornelis, W. A.;
AU  - Fortner, C. L.;
T1  - Acute leukemias
CT  - Acute leukemias
JO  - J. Am. Pharm. Assoc.
JF  - J. Am. Pharm. Assoc.
Y1  - 1972/09/01/
VL  - NS12
IS  - Sep
SP  - 473
EP  - 481
AD  - Patient Care Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, USPHS Hospital, Baltimore, Maryland
N1  - Accession Number: 12-3247; Language: English; References: 7; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Drucella Andersen
N2  - Information on the treatment of the acute leukemias, including some background on the pathology, etiology, and the diagnosis of the diseases are presented as a source of continuing education for the pharmacist.
KW  - Antineoplastic agents--leukemias--acute, therapy, discussion;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Adams, E.;
AU  - Chandler, R.;
AU  - Farkas, R.;
T1  - Sulfur colloid flocculation due to acid leached aluminum
CT  - Sulfur colloid flocculation due to acid leached aluminum
JO  - J. Nucl. Med.
JF  - J. Nucl. Med.
Y1  - 1972/09/01/
VL  - 13
IS  - Sep
SP  - 707
EP  - 708
AD  - National Institutes of Health, Department of Pharmacy, Radiopharmaceutical Services, Bethesda, Maryland 20014
N1  - Accession Number: 10-2389; Language: English; Chemical Name: Aluminum--7429-90-5; Publication Type: Letters; Journal Coden: JNMEAQ; Section Heading: Pharmaceutical Technology; Abstract Author: Nelson Der
N2  - Aluminum may be leached from the closure and/or syringe needle of a commercial kit used to prepare Tc 99m sulfur colloid. The resultant high concentration of aluminum can cause the formation of a flocculent precipitate which will result in an unusable preparation.
KW  - Aluminum--contamination-;
KW  - Needles--aluminum--incompatibilities, flocculation in technetium Tc 99m injection;
KW  - Diagnostic agents--technetium--Tc 99m, sulfur colloid, contamination with aluminum flocculation;
KW  - Equipment--kits--injections, contamination, aluminum flocculation, from acid-leached aluminum in Tc 99m, sulfur colloid;
KW  - Contamination--technetium--Tc 99m, aluminum, from needle produces precipitate;
KW  - Incompatibilities--aluminum and technetium--Tc 99m, from needle results in precipitate;
KW  - Containers--technetium--Tc 99m, aluminum from needle results in precipitate;
KW  - Injections--technetium--Tc 99m, incompatibilities, aluminum from needle results in precipitate;
KW  - Radiopharmaceuticals--technetium--Tc 99m, incompatibilities, aluminum from needle results in precipitate;
KW  - Closures--aluminum--incompatibilities, from needle results in precipitate of technetium Tc 99m;
KW  - Stability--technetium--Tc 99m, incompatible with aluminum needle;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Paull, K. D.;
AU  - Engle, R. R.;
AU  - Twanmoh, L.;
AU  - Wood, H. B., Jr.;
AU  - Driscoll, J. S.;
T1  - Synthesis of 9-(3,4-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine
CT  - Synthesis of 9-(3,4-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1972/09/01/
VL  - 61
IS  - Sep
SP  - 1481
EP  - 1483
SN  - 00223549
AD  - Drug Development Branch, Drug Research and Development, Chemotherapy, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-0148; Language: English; References: 7; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2  - Synthesis of a precursor to the cytotoxic compounds isolated from the genus Thalictrum is described.
KW  - 9-(3,4-Dimethoxyphenoxy)-1,2,10-trimethoxyaporphine--carcinogens-;
KW  - Carcinogens--9-(3,4-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine--synthesis;
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ER  - 

TY  - JOUR
AU  - Connor, Robert J.
T1  - Grouping for Testing Trends in Categorical Data.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1972/09//
VL  - 67
IS  - 339
M3  - Article
SP  - 601
SN  - 01621459
AB  - In many studies there is believed to be a trend in a categorical variate with a continuous variate. Often in these cases it is desired to test for the trend using k groups farmed from the continuous variable. This article is concerned with the grouping problem where the goal is essentially to maximize the asymptotic efficiency of the test. Optimal classes are given for k = 2, 3, 4, 5 and 6 for the uniform, normal and exponential distributions. Also, the number of groups to use and the "robustness" of the optimal grouping are investigated. It is noted that the "mathematical problem" in determining the optimal classes appears in other studies; a rationale for this is presented. [ABSTRACT FROM AUTHOR]
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KW  - DISTRIBUTION (Probability theory)
KW  - MATHEMATICAL analysis
KW  - PROBLEM solving
KW  - CATEGORIES (Mathematics)
KW  - VARIABLES (Mathematics)
KW  - ASYMPTOTIC efficiencies (Statistics)
KW  - VARIATE difference method
KW  - EXPONENTIAL sums
N1  - Accession Number: 4608646; Connor, Robert J. 1; Affiliations: 1: Research mathematical statistician, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; Issue Info: Sep72, Vol. 67 Issue 339, p601; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MATHEMATICAL analysis; Thesaurus Term: PROBLEM solving; Subject Term: CATEGORIES (Mathematics); Subject Term: VARIABLES (Mathematics); Subject Term: ASYMPTOTIC efficiencies (Statistics); Subject Term: VARIATE difference method; Subject Term: EXPONENTIAL sums; Number of Pages: 4p; Document Type: Article
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DB  - buh
ER  - 

TY  - JOUR
AU  - Nylen, Marie U.
AU  - Omnell, Karl-Åke
AU  - Löfgren, Claes-Göran
T1  - An electron microscopic study of tetracycline-induced enamel defects in rat incisor enamel.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1972/09//
VL  - 80
IS  - 5
M3  - Article
SP  - 384
EP  - 409
SN  - 0029845X
AB  - The structure of incremental bands and gross hypoplastic lesions in rat incisor enamel which resulted from single or multiple injections with tetracycline hydrochloride was studied in the electron microscope. Both types of lesions which were investigated previously using microradiography and fluorescence microscopy exhibited many unusual structural features which are discussed in relation to current concepts of normal enamel formation. Disturbances in packing and organization were common to all the lesions indicating a primary interference with the first phase of enamel formation, i.e. matrix formation and initial mineralization. These changes were the main cause of the various mineralization disturbances seen in the microradiograms. Temporary and permanent interference with the second or maturation phase, i.e. a crystal growth, was also evident but only as a corollary to the principal disturbance. This, and other evidence, suggests that tetracycline as well as many other chemical agents achieve their principal effects on enamel formation by injuring pre-secretory or secretory ameloblasts. Thus it appears that most developmental mineralization disturbances are symptomatic of hypoplastic lesions or are a sequela to the cell injury which also causes the hypoplastic lesions. Because of that it is suggested that commonly used division between hypoplastic and hypomineralized defects be abandoned. [ABSTRACT FROM AUTHOR]
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KW  - TETRACYCLINE
KW  - INCISORS
KW  - ELECTRON microscopy
KW  - TEETH
KW  - RATS
KW  - FLUORESCENCE
N1  - Accession Number: 13238105; Nylen, Marie U. 1 Omnell, Karl-Åke 2 Löfgren, Claes-Göran 3; Affiliation:  1: Laboratory of Biological Structure, National Institute of Dental Research, Bethesda, Md  2: National Institutes of Health, Bethesda, Md  3: Department of Oral Roentgen Diagnosis Dentistry, University of Lund, School of Dentistry, Malmö, Sweden; Source Info: 1972, Vol. 80 Issue 5, p384; Subject Term: TETRACYCLINE; Subject Term: INCISORS; Subject Term: ELECTRON microscopy; Subject Term: TEETH; Subject Term: RATS; Subject Term: FLUORESCENCE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 26p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Frandsen, A. M
AU  - MacClendon, B. J.
AU  - Chang, J. J.
AU  - Creighton, W. E.
T1  - The effect of oral rinsing with sodium fluoride on the gingiva of children.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1972/09//
VL  - 80
IS  - 5
M3  - Article
SP  - 445
EP  - 448
SN  - 0029845X
AB  - The effect of a weekly mouthrinsing with a 0.2 % sodium fluoride solution on the gingiva of children was investigated using a double-blind technique. One hundred and twenty-seven Grade 2 children (6-7 years old) and 126 Grade 6 children (12-13 years old) of Negro and Caucasian background formed the study groups. In each age group, fluoride and placebo subgroups were formed which were balanced as to sex, race and number. Assessments were made for the presence of gingival inflammation, plaque and calculus on six selected permanent teeth. The results indicated that in neither age group was the degree of gingivitis influenced by the fluoride mouthrinse. Further, no differences between the two age groups in degree of gingivitis and amount of plaque were noted. [ABSTRACT FROM AUTHOR]
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KW  - GUMS
KW  - PERIODONTIUM
KW  - SODIUM fluoride
KW  - FLUORIDES
KW  - CHILDREN
KW  - MOUTH
KW  - PERIODONTICS
N1  - Accession Number: 13238240; Frandsen, A. M 1 MacClendon, B. J. 2,3 Chang, J. J. 2,3 Creighton, W. E. 4; Affiliation:  1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark  2: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, U.S.A.  3: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and WelfareSan Francisco, California, U.S.A.  4: Division of Public Health, Multnomah County, Oregon, U.S A.; Source Info: 1972, Vol. 80 Issue 5, p445; Subject Term: GUMS; Subject Term: PERIODONTIUM; Subject Term: SODIUM fluoride; Subject Term: FLUORIDES; Subject Term: CHILDREN; Subject Term: MOUTH; Subject Term: PERIODONTICS; Number of Pages: 4p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Moore, J. A.;
T1  - Teratogenicity of hycanthone in mice
CT  - Teratogenicity of hycanthone in mice
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1972/09/08/
VL  - 239
IS  - Sep 8
SP  - 107
EP  - 109
AD  - National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, North Carolina 27709
N1  - Accession Number: 10-2149; Language: English; Chemical Name: Hycanthone--3105-97-3; References: 2; Journal Coden: NATUAS; Section Heading: Toxicity; Abstract Author: Douglas L. Thompson
N2  - Hycanthone methanesulfonate, in doses ranging from 10-50 mg./kg., caused teratogenetic effects in mice.
KW  - Hycanthone--methanesulfonate-;
KW  - Schistosomicides--hycanthone--methanesulfonate, teratogenicity, in mice;
KW  - Teratogenicity--hycanthone--methanesulfonate, in mice;
KW  - Toxicity--hycanthone--methanesulfonate, teratogenicity, in mice;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - HOLLINSHEAD, ARIEL C.
AU  - MCWRIGHT, C. GLEN
AU  - ALFORD, T. CRANDALL
AU  - GLEW, DONALD H.
AU  - GOLD, PHIL
AU  - HERBERMAN, RONALD B.
T1  - Separation of Skin Reactive Intestinal Cancer Antigen from the Carcinoembryonic Antigen of Gold.
JO  - Science
JF  - Science
Y1  - 1972/09/08/
VL  - 177
IS  - 4052
M3  - Article
SP  - 887
EP  - 889
SN  - 00368075
AB  - Soluible fractions of humtlan intestinal cancer and fetal intestinal cell mnembranes produced delayed hypersensitivity reactions in patients with intestinal cancer. These solible fractions and perchloric acid extracts of intestinal cancer cells were fractionated by polacrylamide-gel electrophoresis. The Gold carcinoembryonic antigen was found in a region of the gels diflerent from that of the skin reactive antigen. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85116946; HOLLINSHEAD, ARIEL C. 1; MCWRIGHT, C. GLEN 1; ALFORD, T. CRANDALL 1; GLEW, DONALD H. 1; GOLD, PHIL 2; HERBERMAN, RONALD B. 3; Affiliations: 1: Laboratory for Virus and Cancer Research, George Washington University Medical Center. Washington, D.C. 20037; 2: Division of Clinical Immunology, McGill University Clinic, Montreal General Hospital, Montreal 109, Quebec; 3: Cellular and Tumor Immunology Section, Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/ 8/1972, Vol. 177 Issue 4052, p887; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - NELSON, PHILLIP G.
AU  - PEACOCK, JOHN H.
T1  - Acetylcholine Responses in L Cells.
JO  - Science
JF  - Science
Y1  - 1972/09/15/
VL  - 177
IS  - 4053
M3  - Article
SP  - 1005
EP  - 1007
SN  - 00368075
AB  - L cells, a family of continuous cell lines of mouse fibroblastic origin, generate a prolonged active membrane hyperpolarization (the hyperpolarizing activation response) when stimulated mechanically or electrically lontophoretically applied acetylcholine elicits a similar response; atropine blocks the acetylcholine but not the electrically or Imechanically elicited responses. The hyperpolarizing activation response can also be elicited by electrical, mechanical, or acetylcholine stimulation of cells adjacent to the recorded cell. Propagation of the response from one cell to another is not dependent on direct electrical coupling between cells and is not blocked by application of a bath containing atropine or curare. These results show that L cells are capable of generating an active electrical response that they are sensitive to at least one neurotransmitter (acetylcholine), and that humorally mediated interaction (probably noncholinergic) between L cells occurs. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85116989; NELSON, PHILLIP G. 1; PEACOCK, JOHN H. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/15/1972, Vol. 177 Issue 4053, p1005; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - KAUFMAN, DAVI G.
AU  - BAKER, MARY S.
AU  - SMITH, JOSEPH M.
AU  - HENDERSON, WILLIAM R.
AU  - HARRIS, CURTIS C.
AU  - SPORN, MICHAEL B.
AU  - SAFFIOTTI, UMBERTO
T1  - RNA Metabolism in Tracheal Epithelium: Alteration in Hamsters Deficient in Vitamin A.
JO  - Science
JF  - Science
Y1  - 1972/09/22/
VL  - 177
IS  - 4054
M3  - Article
SP  - 1105
EP  - 1108
SN  - 00368075
AB  - The electrophoretic pattern of RNA molecules that are synthesized in vitro in tracheal epithelium from hamsters deficient in vitamin A differs from that of RNA synthesized in normal, pair-fed control hamsters. There is less RNA of low electrophoretic mobility in the epithelial cells deficient in vitamin A. This alteration is reversed after the deficient animals have been treated with vitamin A. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117020; KAUFMAN, DAVI G. 1; BAKER, MARY S. 1; SMITH, JOSEPH M. 1; HENDERSON, WILLIAM R. 1; HARRIS, CURTIS C. 1; SPORN, MICHAEL B. 1; SAFFIOTTI, UMBERTO 1; Affiliations: 1: Lung Cancer Unit, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1105; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - ABRELL, JOHN W.
AU  - SMTITH, R. GRAHAM
AU  - ROBERT, MARJORIE S.
AU  - GALLO, ROBERT C.
T1  - DNA Polymerases from RNA Tumor Viruses and Human Cells: Inhibition by Polyuridylic Acid.
JO  - Science
JF  - Science
Y1  - 1972/09/22/
VL  - 177
IS  - 4054
M3  - Article
SP  - 1111
EP  - 1114
SN  - 00368075
AB  - Polyuridylic acid inhibited DNA polyinerases purified from three species of oncornaviruses as well as three out of seven DNA polymerases purified from cells. Viral and cellular DNA polymerases could not be distinguished by polyuridylic acid inhibition, but were easily distinguished by their temnplate prefer-ences in the presence of magnesium. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117023; ABRELL, JOHN W. 1; SMTITH, R. GRAHAM 1; ROBERT, MARJORIE S. 1; GALLO, ROBERT C. 1,2; Affiliations: 1: Bionetics Research Laboratories, Bethesda, Maryland 20014; 2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1111; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - SCOLNICK, EDWARD M.
AU  - PARKS, WADE P.
AU  - TODARO, GEORGE J.
T1  - Reverse Transcriptases of Primate Viruses as Immunological Markers.
JO  - Science
JF  - Science
Y1  - 1972/09/22/
VL  - 177
IS  - 4054
M3  - Article
SP  - 1119
EP  - 1121
SN  - 00368075
AB  - Antibodies were prepared against the DNA polymerases (reverse transcriptases) of three potentially oncogenic RNA viruses of primates. Two type C viruses, isolated from a woolly mionkey fibrosarcoma and fromn a gibbon ape lymphosarcoma, have polyimerases that are immunologically related to each other and are distinct from the type C viruses isolated from other mammals. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117026; SCOLNICK, EDWARD M. 1; PARKS, WADE P. 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leuikemia and Lymphoma Branch and Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1119; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WYATT, RICHARD J.
AU  - VAUGHAN, THOMAS
AU  - GALANTER, MARC
AU  - KAPLAN, JONATHAN
AU  - GREEN, RICHARD
T1  - Behavioral Changes of Chronic Schizophrenic Patients Given L-5-Hydroxytryptophan.
JO  - Science
JF  - Science
Y1  - 1972/09/22/
VL  - 177
IS  - 4054
M3  - Article
SP  - 1124
EP  - 1126
SN  - 00368075
AB  - Oral admninistration of the serotonin precur''sort L-5-hylroxytryptophan with a peripheral decarboxylase inihibitor produced Mild to moderate improveilzent in six of seven chronic uindciffer-entiated schizophreniic patienits who were resistanit to phenothiazine treatment, as coinpared to ani oral administration of a placebo. Two of foutr chroniic parainoid schizophrenic patients who wsere resistant to pheniothiazine treatment becamtie worse with 5-hydroxytryptophanl, olle iunproved. It is presumed that these psychological changes were directly or indirectly prodiuced from increases in brain serotonlin. Indirect data from aniimals anid hiumiians indicate that there mlay be an abnorimality in serotonini metabolism in soime schizophrenics. While ouir data are conisistelnt iwith this hypothesis, other explanations for otir data imust be entertainied. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117029; WYATT, RICHARD J. 1; VAUGHAN, THOMAS 1; GALANTER, MARC 1; KAPLAN, JONATHAN 1; GREEN, RICHARD 1; Affiliations: 1: Laboratory of Clinical Psychopharmnacology, Division of Special Menztal Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1124; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - LAMPRECHT, FRIEDHELM
AU  - EICHELMAN, BURR
AU  - THOA, NGUYEN B.
AU  - WILLIAMS, REDFORD B.
AU  - KoPIN, IRWIN J.
T1  - APPOINTMENTS.
JO  - Science
JF  - Science
Y1  - 1972/09/29/
VL  - 177
IS  - 4055
M3  - Article
SP  - 1179
EP  - 1215
SN  - 00368075
N1  - Accession Number: 85138456; LAMPRECHT, FRIEDHELM 1; EICHELMAN, BURR 2; THOA, NGUYEN B. 3; WILLIAMS, REDFORD B. 4; KoPIN, IRWIN J. 3; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychobiology, National Institute of Mental Health; 3: Laboratory of Clinical Science; 4: Laboratory of Clinical Psychobiology; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1179; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Aviv, DVORA
AU  - THOMPSON, E. BRAD
T1  - Variation in Tyrosine Aminotransferase Induction in HTC Cell Clones.
JO  - Science
JF  - Science
Y1  - 1972/09/29/
VL  - 177
IS  - 4055
M3  - Article
SP  - 1202
EP  - 1203
SN  - 00368075
AB  - Examination of tyrosine aminotransferase induction in many HTC cell subclones revealed a wide and unstable distribution of inducibility. The instability of this phenotype cannot easily be explained by classical mutation rates. These observations may be important in interpreting certain cell fusion experiments. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85138472; Aviv, DVORA 1; THOMPSON, E. BRAD 1; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1202; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - LAMPRECHT, FRIEDHELM
AU  - EICHELMAN, BURR
AU  - THOA, NGUYEN B.
AU  - WILLIAMS, REDFORD B.
AU  - KoPIN, IRWIN J.
T1  - Rat Fighting Behavior: Serum Dopamine-β-Hydroxylase and Hypothalamic Tyrosine Hydroxylase.
JO  - Science
JF  - Science
Y1  - 1972/09/29/
VL  - 177
IS  - 4055
M3  - Article
SP  - 1214
EP  - 1215
SN  - 00368075
AB  - Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shockinduced fighting, in the activity of serum dopamine-β-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine- f,-hydroxylase activity retuirned to normal; it therefore appears that longterm stress may increase central catecholamine synthesis possibly resulting in a persistent increase in aggressive behavior. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85138478; LAMPRECHT, FRIEDHELM 1; EICHELMAN, BURR 2; THOA, NGUYEN B. 3; WILLIAMS, REDFORD B. 4; KoPIN, IRWIN J. 3; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychobiology, National Institute of Mental Health; 3: Laboratory of Clinical Science; 4: Laboratory of Clinical Psychobiology; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1214; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Weppner, R. S.;
AU  - Stephens, R. C.;
AU  - Conrad, H. T.;
T1  - Methadone: some aspects of its legal and illegal use
CT  - Methadone: some aspects of its legal and illegal use
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1972/10/01/
VL  - 129
IS  - Oct
SP  - 451
EP  - 455
SN  - 0002953X
AD  - National Institute of Mental Health, Clinical Research Center, Leestown Pike, Lexington, Kentucky 40507
N1  - Accession Number: 10-5026; Language: English; Chemical Name: Methadone--76-99-3; References: 12; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; PharmacologySociology, Economics and Ethics; Abstract Author: Louis Houle, Jr.
N2  - In a study of 336 patients, it is found that methadone does not block the euphoric effects of other opiates, and that methadone is the drug of choice for some addicts. Three basic areas are covered: (1) the prevalence of methadone use among a sample of institutionalized narcotic addicts; (2) the circumstances of illegal methadone use among this sample of narcotic addicts; and (3) the circumstances surrounding previous participation in methadone maintenance programs (including illegal drug use). The results show that success of methadone maintenance does not mean the programs are immune to diversion of methadone or to other abuses.
KW  - Methadone--maintenance-;
KW  - Drug abuse--methadone--maintenance, diversion, discussion, in patients;
KW  - Dependence--narcotics--therapy, methadone maintenance, abuses, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Berk, P. D.;
AU  - Blaschke, T. F.;
T1  - Detection of Gilbert's syndrome in patients with hemolysis. Method using radioactive chromium
CT  - Detection of Gilbert's syndrome in patients with hemolysis. Method using radioactive chromium
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/10/01/
VL  - 77
IS  - Oct
SP  - 527
EP  - 531
SN  - 00034819
AD  - Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1257; Language: English; Chemical Name: Chromium--7440-47-3; Therapeutic Class: (36:00); AHFS Class: Diagnostic agents chromium; References: 17; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2  - An equation was derived which permits the recognition of Gilbert's syndrome from radioactive chromium (Cr-51) studies alone, of patients who have both hemolysis and Gilbert's syndrome.
KW  - Chromium--Cr 51-;
KW  - Radioisotopes--\SU/51\BS/Cr--diagnosis, of Gilbert's syndrome, in patients with hemolysis;
KW  - Diagnostic agents--chromium--Cr 51, diagnosis of Gilbert's syndrome, in patients with hemolysis;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Deisseroth, A.;
AU  - Morganroth, J.;
AU  - Winokur, S.;
T1  - Quinidine-induced liver disease
CT  - Quinidine-induced liver disease
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1972/10/01/
VL  - 77
IS  - Oct
SP  - 595
EP  - 597
SN  - 00034819
AD  - Reprints: National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
AD  - Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts
N1  - Accession Number: 10-1213; Language: English; Chemical Name: Quinidine--56-54-2; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs quinidine; References: 3; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2  - Temperature, serum glutamic oxalacetic transaminase, serum glutamic pyruvic transaminase, lactic dehydrogenase, alkaline phosphatase, and leucine aminopeptidase elevations were observed in a 77-year-old women during 2 separate periods of oral quinidine gluconate administration. The patient received 330 mg. of quinidine gluconate, every 8 hours orally and after 11 days the patient became febrile. Therapy was stopped and later reinstituted with the same results. Since all of these measurements returned to normal levels after discontinuing quinidine, it was concluded that quinidine had a direct toxic effect on the liver in this patient. This patient is the second known case of this toxic effect.
KW  - Quinidine--gluconate-;
KW  - Cardiac drugs--quinidine--gluconate, febrile reaction, case report;
KW  - Drugs, adverse reactions--quinidine--gluconate, febrile reaction, case report;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Elfenbein, G.J.
AU  - Shevach, E.M.
AU  - Green, I.
T1  - Demonstration of Thymus-Derived Cell Surface Antigens on Various Guinea-Pig Lymphoid Cell Populations by a Micro-Immune Adherence Technique.
JO  - Immunology
JF  - Immunology
Y1  - 1972/10//
VL  - 23
IS  - 4
M3  - Article
SP  - 523
EP  - 535
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A micro-immune adherence assay employing direct microscopic observation was used to detect the presence of thymus-derived cell antigenic specificities on guinea-pig lymph node cells, purified peritoneal exudate lymphocytes, and thymocytes using a heterologous burro anti-guinea-pig thyrnocyte serum. A method is described for the direct determination of thymus-derived cell specificity of anti-lymphocyte sera. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE system
KW  - BIOLOGICAL assay
KW  - T cells
KW  - CELL surface antigens
KW  - LYMPHOID tissue
KW  - GUINEA pigs as laboratory animals
KW  - LYMPHOCYTES
KW  - THYMUS
N1  - Accession Number: 13379187; Elfenbein, G.J. 1 Shevach, E.M. 1 Green, I. 1; Affiliation:  1: Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA; Source Info: Oct72, Vol. 23 Issue 4, p523; Subject Term: IMMUNE system; Subject Term: BIOLOGICAL assay; Subject Term: T cells; Subject Term: CELL surface antigens; Subject Term: LYMPHOID tissue; Subject Term: GUINEA pigs as laboratory animals; Subject Term: LYMPHOCYTES; Subject Term: THYMUS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levine, S.
AU  - Sowinski, R.
AU  - Gruenewald, R.
AU  - Kies, M.W.
T1  - Experimental Allergic Encephalomyelitis: PRODUCTION BY MYELIN BASIC PROTEIN ADSORBED ON  PARTICULATE ADJUVANTS.
JO  - Immunology
JF  - Immunology
Y1  - 1972/10//
VL  - 23
IS  - 4
M3  - Article
SP  - 609
EP  - 614
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Aqueous solutions of myelin basic proteins do not cause allergic encephalomyelitis (EAE). They were rendered encephalitogenic for rats by admixture with kaolin, talc, glass, uncharged and cation exchange polystyrene resins, carbon and microspheres. Binding of basic protein to some of these aqueous particulate adjuvants was demonstrated spectrophotometrically. Absorption into the lymphatic system was demonstrated histologically. Binding of basic protein to adjuvant can occur in vivo. Basic protein was also bound by a carbon of relatively large particle size. Nevertheless, this carbon and certain other particulates failed to act as adjuvants, probably because they were not absorbed into the lymphatic system. An anion exchange resin, carbonyl iron, and some other particulates were abundantly absorbed into the lymphatic system but exhibited no adjuvant effect with basic protein, even though they do have an adjuvant effect for whole neural tissue. Their lack of effect with the purified antigen was explained by failure to bind basic protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALLERGIC encephalomyelitis
KW  - IMMUNOLOGICAL adjuvants
KW  - MYELIN basic protein
KW  - PROTEIN binding
KW  - SPECTROPHOTOMETRY
KW  - LYMPHATICS
KW  - BASIC proteins
KW  - CARBON
N1  - Accession Number: 13379394; Levine, S. 1 Sowinski, R. 1 Gruenewald, R. 1 Kies, M.W. 1; Affiliation:  1: Pathology Department, New York Medical College Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York and Section of Myelin Chemistry, National Institute of Mental Health, USA; Source Info: Oct72, Vol. 23 Issue 4, p609; Subject Term: ALLERGIC encephalomyelitis; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: MYELIN basic protein; Subject Term: PROTEIN binding; Subject Term: SPECTROPHOTOMETRY; Subject Term: LYMPHATICS; Subject Term: BASIC proteins; Subject Term: CARBON; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenberg, Nathan
T1  - MMPI ALCOHOLISM SCALES.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1972/10//
VL  - 28
IS  - 4
M3  - Article
SP  - 515
EP  - 522
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article obtains comparative validities for MMPI Alcoholism Scales. The sample was obtained from the VA Hospital, Fort Meade, South Dakota. The alcoholics consisted of 111 male veterans admitted both on a voluntary and on a commitment basis to a special treatment unit for alcoholics in which those with psychotic symptoms, other than those due to acute alcohol intoxication or to withdrawal from alcohol, were excluded. The Rosenberg Composite Scale consists of 6 MMPI items common to all three of the most promising scales, as well as 21 items common to two scales.
KW  - PSYCHIATRIC rating scales
KW  - ALCOHOLICS
KW  - ALCOHOLISM -- Treatment
KW  - SUBSTANCE abuse
KW  - VETERANS
KW  - SOCIAL science research
KW  - ALCOHOL use
KW  - FORT Meade (S.D.)
N1  - Accession Number: 15866611; Rosenberg, Nathan 1; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism.; Source Info: Oct1972, Vol. 28 Issue 4, p515; Subject Term: PSYCHIATRIC rating scales; Subject Term: ALCOHOLICS; Subject Term: ALCOHOLISM -- Treatment; Subject Term: SUBSTANCE abuse; Subject Term: VETERANS; Subject Term: SOCIAL science research; Subject Term: ALCOHOL use; Subject Term: FORT Meade (S.D.); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Tauraso, N.;
AU  - Myers, M.;
AU  - Nau, E.;
AU  - O'Brien, T.;
AU  - Spindel, S.;
AU  - \ET/;
T1  - Effect of interval between inoculation of live smallpox and yellow fever vaccines on antigenicity in man
CT  - Effect of interval between inoculation of live smallpox and yellow fever vaccines on antigenicity in man
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1972/10/01/
VL  - 126
IS  - Oct
SP  - 362
EP  - 371
SN  - 00221899
AD  - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-2183; Language: English; References: 23; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - In the first part of this study, volunteers were initially given smallpox vaccine; yellow fever vaccine was given to groups of these volunteers simultaneously, and 3, 7, 14, and 28 days later; Part two was essentially the same, except that yellow fever vaccine was administered initially, and the time of smallpox vaccination varied as indicated above. The results showed that the reactogenicity and antigenicity of live smallpox and yellow fever vaccines were unaffected by the interval between inoculations. The advantages of administering live virus vaccines, either simultaneously or at different times, were evaluated. It was suggested that the recommendations on immunization with smallpox and yellow fever vaccines be modified in light of the findings of this study.
KW  - Smallpox vaccines--dosage schedules-;
KW  - Yellow fever vaccines--dosage schedules-;
KW  - Dosage schedules--smallpox vaccines--and yellow fever vaccines, effect of interval between inoculation on antigenicity in man;
KW  - Immunization--smallpox--and yellow fever, effect of interval between inoculation on antigenicity in man;
KW  - Immunization--yellow fever--and smallpox, effect of interval between inoculation on antigenicity in man;
KW  - Drug interactions--smallpox and yellow fever vaccines--lack, effect of interval between inoculation on antigenicity in man;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Stripp, B.;
AU  - Gillette, J. R.;
T1  - Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity
CT  - Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1972/10/01/
VL  - 61
IS  - Oct
SP  - 1682
EP  - 1685
SN  - 00223549
AD  - Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Besthesda, Maryland 20014
N1  - Accession Number: 11-4718; Language: English; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Pharmacology
KW  - Metabolism--drugs--factors affecting pharmacology and toxicity;
KW  - Toxicity--drugs--metabolism, factors affecting;
KW  - Research--drugs--metabolism, factors affecting pharmacology and toxicity;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-41458-019
AN  - 2013-41458-019
AU  - Shore, Milton F.
T1  - Review of Adolescent psychiatry, Vol. I: Developmental and clinical studies, Adolescence, Teaching and learning adolescent psychiatry, and Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1972/10//
VL  - 42
IS  - 5
SP  - 884
EP  - 887
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41458-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Psychiatry; Mental Health Personnel; Professional Organizations; Psychiatric Training; Scientific Communication. Minor Descriptor: Teaching. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Feinstein, Sherman C. (Ed); Giovacchini, Peter (Ed); Miller, Arthur A. (Ed). Adolescent psychiatry, Vol. 1: Developmental and clinical studies=New York: Basic Books. 552 pp. $15.00; 1971. Josselyn, Irene M. Adolescence=New York: Harper & Row. 213 pp. $5.95; 1971. Offer, Daniel (Ed); Masterson, John F. (Ed). Teaching and learning adolescent psychiatry=Springfield, III.: Charles C. Thomas. 157 pp. $9.50; 1971. No authorship indicated. Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971=Washington, D.C.: U.S. Government Printing Office. $2.50; 1971. Page Count: 4. Issue Publication Date: Oct, 1972. 
AB  - Reviews the books, Adolescent Psychiatry, Vol. I: Developmental and clinical studies edited by Sherman C. Feinstein, Peter Giovacchini and Arthur A. Miller (1971), Adolescence by Irene M. Josselyn (1971) Teaching and Learning Adolescent Psychiatry edited by Daniel Offer and John F. Masterson (1971) and Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971 (1971). The three psychiatric books are collections of papers by well-known mental health professionals; the White House Conference was a planned attempt to involve some 1,000 adolescents with a wide range of backgrounds and interests, with 500 'older' professionals to work together and reflect on both the current problems of the society and the problems in which youth themselves are directly involved. Keniston, in an excellent article in the Feinstein book, describes the set of historical and social circumstances that has given rise to a new recognition of adolescence and youth as distinct parts of the life cycle. Dommermuth, in the Offer book, discusses the sociological forces that take over when a new field is identified. A professional organization arises, which then sponsors publications. Despite their constant references to Erikson, the three psychiatric books do not adequately meet his standards. The White House Conference Report, on the other hand, seems to be a refreshing step in that direction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adolescent psychiatry
KW  - White House Conference
KW  - professional organizations
KW  - mental health professionals
KW  - psychiatry teaching
KW  - psychiatry learning
KW  - 1972
KW  - Adolescent Psychiatry
KW  - Mental Health Personnel
KW  - Professional Organizations
KW  - Psychiatric Training
KW  - Scientific Communication
KW  - Teaching
KW  - 1972
U2  - Feinstein, Sherman C. (Ed); Giovacchini, Peter (Ed); Miller, Arthur A. (Ed). (1971); Adolescent psychiatry, Vol. 1: Developmental and clinical studies; New York: Basic Books. 552 pp. $15.00
U2  - Josselyn, Irene M. (1971); Adolescence; New York: Harper & Row. 213 pp. $5.95
U2  - Offer, Daniel (Ed); Masterson, John F. (Ed). (1971); Teaching and learning adolescent psychiatry; Springfield, III.: Charles C. Thomas. 157 pp. $9.50
U2  - No authorship indicated. (1971); Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971; Washington, D.C.: U.S. Government Printing Office. $2.50
DO  - 10.1111/j.1939-0025.1972.tb00775.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - LEVITAN, HERBERT
AU  - BARKER, JEFFERY L.
T1  - Membrane Permeability: Cation Selectivity Reversibly Altered by Salicylate.
JO  - Science
JF  - Science
Y1  - 1972/10/06/
VL  - 178
IS  - 4056
M3  - Article
SP  - 63
EP  - 64
SN  - 00368075
AB  - The effect of salicylate on the relative cation permeability of a membrane was investigated in large, identified molluscan neurons, with the use of intracellular recording techniques. Salicylate caused a reversible, dose-dependent decrease in the permeability of rubidium, cesium, sodium, and lithium ions relative to that of potassium ions. The results suggest that the changes in cation selectivity result from the adsorption of salicylate anions to the membrane with a subsequent increase in the density and field strength of anionic sites in the membrane. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519085; LEVITAN, HERBERT 1; BARKER, JEFFERY L. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/6/1972, Vol. 178 Issue 4056, p63; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KNAZEK, RICHARD A.
AU  - GULLINO, PIETRO M.
AU  - KOHLER, PETER O.
AU  - DEDRICK, ROBERT L.
T1  - Cell Culture on Artificial Capillaries: An Approach to Tissue Growth in vitro.
JO  - Science
JF  - Science
Y1  - 1972/10/06/
VL  - 178
IS  - 4056
M3  - Article
SP  - 65
EP  - 67
SN  - 00368075
AB  - Artificial capillaries perfused with culture medium provide a matrix in which cells can attain tissue-like densities in vitro. Products secreted into the medium can be measured as indicators of cell function or may be recovered for other purpose without disturbing the culture. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519083; KNAZEK, RICHARD A. 1; GULLINO, PIETRO M.; KOHLER, PETER O.; DEDRICK, ROBERT L.; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/6/1972, Vol. 178 Issue 4056, p65; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - THOA, N. B.
AU  - EICHELMAN, B.
AU  - RICHARDSON, J. S.
AU  - JACOBOWITZ, D.
T1  - 6-Hydroxydopa Depletion of Brain Norepinephrine and the Facilitation of Aggressive Behavior.
JO  - Science
JF  - Science
Y1  - 1972/10/06/
VL  - 178
IS  - 4056
M3  - Article
SP  - 75
EP  - 77
SN  - 00368075
AB  - A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519104; THOA, N. B. 1; EICHELMAN, B. 1; RICHARDSON, J. S. 1; JACOBOWITZ, D. 1; Affiliations: 1: Laboratories of Clinical Science and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 10/6/1972, Vol. 178 Issue 4056, p75; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Howard, W. A.;
AU  - Collins, W. E.;
T1  - Heparin therapy in simian Plasmodium knowlesi malaria
CT  - Heparin therapy in simian Plasmodium knowlesi malaria
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1972/10/07/
VL  - 2
IS  - Oct 7
SP  - 738
EP  - 739
SN  - 00237507
AD  - Primate Malaria Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30341
N1  - Accession Number: 10-2826; Language: English; Chemical Name: Heparin--9005-49-6; Therapeutic Class: (20:12.04); AHFS Class: Anticoagulants heparin; References: 14; Journal Coden: LANCAO; Section Heading: Drug Evaluations
N2  - Intravenous heparin (450 units/kg. every 8 hours or 500 units/kg. every 6 hours) had no antimalarial activity against Plasmodium knowlesi malaria in monkeys. The survival of infected monkeys was not influenced by 450 units of heparin/kg. administered I.V. every 8 hours. Disseminated intravascular coagulation, therefore, does not seem to be the major cause of death in these animals. Routine use of heparin in complicated falciparum malaria in man must await controlled studies which demonstrate efficacy.
KW  - Heparin--malaria-;
KW  - Anticoagulants--heparin--malaria, Plasmodium knowlesi, lack, effect, in monkeys;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - CATTABENI, F.
AU  - KoSLOW, S. H.
AU  - COSTA, E.
T1  - Gas Chromatographic-Mass Spectrometric Assay of Four Indole Alkylamines of Rat Pineal.
JO  - Science
JF  - Science
Y1  - 1972/10/13/
VL  - 178
IS  - 4057
M3  - Article
SP  - 166
EP  - 168
SN  - 00368075
AB  - Gas chromatography-mass spectromnetry was used to quantitate serotonin, N-acetylserotonin, 5-methoxytryptamine, and melatonin in single rat pineal glands. After gas chromatographic separation, the ion density of specific fragments of each indole was measured with mass spectrometry. Sensitivity of this indole assay is of the order of 10-12 to 10-13 mole. Routinely, specificity is based on gas chromatographic retention time and the recording of the ion density generated by specific fragments. Absolute identification of the extracted indoles was based on multiple ion detection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85138509; CATTABENI, F. 1; KoSLOW, S. H. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 10/13/1972, Vol. 178 Issue 4057, p166; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GAVIN III, JAMES R.
AU  - BUELL, DONALD N.
AU  - ROTH, JESSE
T1  - Water-Soluble Insulin Receptors from Human Lymphocytes secondreported in intact cells.
JO  - Science
JF  - Science
Y1  - 1972/10/13/
VL  - 178
IS  - 4057
M3  - Article
SP  - 168
EP  - 169
SN  - 00368075
AB  - Specific insulin receptors from human lymphocytes in culture have been prepared in aqueous solution without use of detergents or related compounds. Receptors prepared in this fashion exhibit characteristics identical to those [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85138510; GAVIN III, JAMES R. 1; BUELL, DONALD N. 2; ROTH, JESSE 3; Affiliations: 1: Section on Diabetes and Intermediary Metabolism, Clinical Endocrinology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; 2: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Section on Diabetes and Intermediary Metabolism, National Institute of Arthritis, Metabolism, and Digestive Diseases Bethesda, Maryland 20014; Issue Info: 10/13/1972, Vol. 178 Issue 4057, p168; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Larson, S. M.;
AU  - Graff, K. S.;
AU  - Tretner, I.-H.;
AU  - Zager, R. F.;
AU  - Henderson, E. A.;
AU  - \ET/;
T1  - Positive gallium 67 photoscan in myeloblastoma
CT  - Positive gallium 67 photoscan in myeloblastoma
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1972/10/16/
VL  - 222
IS  - Oct 16
SP  - 321
EP  - 323
AD  - Building 10, Room 1B53, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1046; Language: English; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals gallium citrate; References: 3; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - Case summaries are presented on 2 patients in whom myeloblastomas of the breast were detected by gallium citrate Ga 67 photoscanning.
KW  - Gallium citrate--Ga 67-;
KW  - Radiopharmaceuticals--gallium citrate--Ga 67, photoscans, myeloblastoma detection, case reports;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - BASTIAN, F. O.
AU  - RABSON, A. S.
AU  - YEE, C. L.
AU  - TRALKA, T. S.
T1  - Herpesvirus hominis: Isolation from Human Trigeminal Ganglion.
JO  - Science
JF  - Science
Y1  - 1972/10/20/
VL  - 178
IS  - 4058
M3  - Article
SP  - 306
EP  - 307
SN  - 00368075
AB  - Herpesvirus hominis was isolated from the trigeminal ganglion obtained at autopsy from 1 of 22 patients with no clinical evidence of active herpetic disease, and from one patient with malignant lymphoma who died with herpes zoster on the abdomen, pulmonary cytomegalic inclusion disease, and possible oral herpes simplex. Virus was isolated by cocultivation of explants of ganglion with monolayers of Vero green monkey kidney cells and required 3 weeks of culture before viral cytopathic eflects were evident. These observations support the concept that latent infection of sensory ganglia may be the sotirce of virus in recurrent herpetic disease in man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546778; BASTIAN, F. O. 1; RABSON, A. S. 1; YEE, C. L. 1; TRALKA, T. S. 1; Affiliations: 1: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/20/1972, Vol. 178 Issue 4058, p306; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bagley, C. M., Jr.;
AU  - Young, R. C.;
AU  - Canellos, G. P.;
AU  - DeVita, V. T.;
T1  - Treatment of ovarian carcinoma: possibilities for progress
CT  - Treatment of ovarian carcinoma: possibilities for progress
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1972/10/26/
VL  - 287
IS  - Oct 26
SP  - 856
EP  - 862
SN  - 00284793
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, Bethesda, Maryland 20014
N1  - Accession Number: 10-1781; Language: English; References: 53; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Joan Lentine
N2  - Classification of ovarian adenocarcinoma, and modes of therapy such as surgery, radiotherapy, chemotherapy, and a combination of radiotherapy and chemotherapy are discussed. Alkylating agents discussed are melphalan, chlorambucil, cyclophosphamide, and triethylene-thiophosphoramide (thiotepa). Other chemotherapeutic agents (nonalkylating) discussed are fluorouracil, methotrexate, hexamethylmelamine, vinblastine, diethylstilbestrol and hydroxyprogesterone.
KW  - Antineoplastic agents--carcinoma--ovarian, therapy, discussion;
KW  - Cancer--ovarian--antineoplastic agents, therapy, discussion;
KW  - Combined therapy--antineoplastic agents--cancer, ovarian, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Becker, Edwin D.
AU  - Farrar, T. C.
T1  - Fourier Transform Spectroscopy.
JO  - Science
JF  - Science
Y1  - 1972/10/27/
VL  - 178
IS  - 4059
M3  - Article
SP  - 361
EP  - 368
SN  - 00368075
N1  - Accession Number: 85158185; Becker, Edwin D. 1; Farrar, T. C. 2; Affiliations: 1: Chief, Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Director, Research and Development, JEOL, Inc., Cranford, New Jersey 07016; Issue Info: 10/27/1972, Vol. 178 Issue 4059, p361; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carter, S. K.;
T1  - New drugs on the horizon in bronchogenic carcinoma
CT  - New drugs on the horizon in bronchogenic carcinoma
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1972/11/01/
VL  - 30
IS  - Nov
SP  - 1402
EP  - 1409
AD  - Cancer Therapy Evaluation Branch, Chemotherapy Program, National Cancer Institute, Bethesda, Maryland
N1  - Accession Number: 11-2637; Language: English; Trade Name: BCNU--CCNU--NSC-102816--NSC-109724--NSC-129943--NSC-119875--Adriamycin--Iphosphamide--ICRF-159; Generic Name: Carmustine; Lomustine; 5-Azacytidine; Isophosphamide; Razoxane; cis-Diaminedichloroplatinum; Doxorubicin; Isophosphamide; Razoxane; Chemical Name: Carmustine--154-93-8 Lomustine--13010-47-4 Doxorubicin--23214-92-8 Bleomycin--11056-06-7 Razoxane--21416-87-5; References: 57; Journal Coden: CANCARCANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - A discussion of preliminary testing of a variety of antineoplastic agents, using lung cancer patients in the clinical trials, is presented. Among the new drugs sponsored for trial, which have shown evidence of activity against lung cancer, are the nitrosoureas, of which 3 are in various stages of clinical evaluation. Carmustine (BCNU) has shown activity in 9/83 (11%) while lomustine (CCNU) has shown activity in 11/52 (21%). The newest analog, methyl CCNU, is of great interest because of its superior activity against the advanced Lewis lung tumor. Other new agents which have shown some evidence of activity include adriamycin (30/147; doxorubicin), hexamethylmelamine (42/202), and bleomycin (5/62). Among the new drugs just completing phase I evaluation and awaiting trial in lung cancer are: iphosphamide (NSC-109724; isophosphamide), ICRF-159 (NSC-129943; razoxane), 5-azacytidine (NSC-102816), and cis-diaminedichloroplatinum (NSC-119875).
KW  - Carmustine--cancer-;
KW  - Lomustine--cancer-;
KW  - Lomustine--methyl-;
KW  - Hexamethylmelamine--cancer-;
KW  - Doxorubicin--cancer-;
KW  - Bleomycin--cancer-;
KW  - Isophosphamide--antineoplastic agents-;
KW  - Razoxane--antineoplastic agents-;
KW  - 5-Azacytidine--antineoplastic agents-;
KW  - cis-Diaminedichloroplatinum--antineoplastic agents-;
KW  - Antineoplastic agents--cancer--lung, preliminary trials of investigational drugs, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Greene, W.;
AU  - Huffman, D.;
AU  - Wiernik, P. H.;
AU  - Schimpff, S.;
AU  - Benjamin, R.;
AU  - \ET/;
T1  - High-dose daunorubicin therapy for acute nonlymphocytic leukemia: correlation of response and toxicity with pharmacokinetics and intracellular daunorubicin reductase activity
CT  - High-dose daunorubicin therapy for acute nonlymphocytic leukemia: correlation of response and toxicity with pharmacokinetics and intracellular daunorubicin reductase activity
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1972/11/01/
VL  - 30
IS  - Nov
SP  - 1419
EP  - 1427
AD  - Medicine and Biochemistry Sections of the Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1  - Accession Number: 11-2261; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 25; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Daunorubicin (daunomycin), administered in large doses intermittently to 23 patients with acute nonlymphocytic leukemia, produced a complete hematologic remission rate of 33%. Five of 16 (31%) previously untreated patients achieved complete hematologic remission. Clinical response was closely correlated with in vitro determinations of peripheral leukemic myeloblast daunorubicin reductase activity. The measurement of the activity of daunorubicin reductase in peripheral myeloblasts from patients prior to therapy may serve to identify those patients least likely to respond favorably to daunorubicin therapy in the dose and schedule used in this study.
KW  - Daunomycin--leukemias-;
KW  - Antineoplastic agents--daunomycin--leukemias, acute nonlymphocytic, correlation of response to myeloblast reductase activity, in patients;
KW  - Pharmacokinetics--daunomycin--leukemias, acute nonlymphocytic, correlation of response to myeloblast reductase activity, in patients;
KW  - Dosage--daunomycin--high, acute nonlymphocytic leukemia therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Catalona, W. J.
AU  - Taylor, P. T.
AU  - Chretien, P. B.
T1  - QUANTITATIVE DINITROCHLOROBENZENE CONTACT SENSITIZATION IN A NORMAL POPULATION.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1972/11//
VL  - 12
IS  - 3
M3  - Article
SP  - 325
EP  - 333
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Using a quantitative method based on the sponteneous flare phenomenon, contact sensitization to DNCB was studied in 143 healthy volunteers between the ages of 20 and 80 yr. A spontaneous flare reaction occurred in 965% of subjects tested, regardless of age, and a correlation was demonstrated between the intensity of the primary response to DNCB and the threshold dose of DNCB required to elicit an anamnestic response. The results are in striking contrast to a 40% incidence of spontaneous flare reactions previously found in cancer patients using the same method. These findings show that this method of assaying reactivity to DNCB detects abnormalities of cell-mediated immunity not demonstrated by qualitative methods. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DINITROCHLOROBENZENE
KW  - CHLOROBENZENE
KW  - CONTACT dermatitis
KW  - CELLULAR immunity
KW  - CANCER patients
KW  - IMMUNE response
N1  - Accession Number: 14545688; Catalona, W. J. 1 Taylor, P. T. 1 Chretien, P. B. 1; Affiliation:  1: Surgery Branch, National Cancer Institute, National Cancer Institute, N.I.H., Bethesda, U.S.A.; Source Info: Nov72, Vol. 12 Issue 3, p325; Subject Term: DINITROCHLOROBENZENE; Subject Term: CHLOROBENZENE; Subject Term: CONTACT dermatitis; Subject Term: CELLULAR immunity; Subject Term: CANCER patients; Subject Term: IMMUNE response; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Powell, Deborah E.
AU  - Steinberg, A. D.
T1  - THE PATHOGENESIS OF AUTOIMMUNITY IN NEW ZEALAND MICE.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1972/11//
VL  - 12
IS  - 3
M3  - Article
SP  - 419
EP  - 427
PB  - Wiley-Blackwell
SN  - 00099104
AB  - New Zealand mice spontaneously develop antibodies to double-stranded RNA and DNA. The appearance of these antibodies is accelerated by the administration of the synthetic double-stranded RNA, polyinosinic polycytidylic acid (poly I ˙ poly C). Since poly I ˙ poly C is known to act both as a nucleic acid antigen and as an adjuvant, the mechanism of nucleic acid antibody stimulation was studied to determine which property of poly I ˙ poly C was operative. NZB/NZW mice were made tolerant to poly I ˙ poly C as an antigen with cyclophosphamide. They were then given 10 pg or 150 pg of poly I ˙ poly C three times per week. Tolerant mice given 10 pg of poly I ˙ poly C had acceleration of anti- bodies to DNA but not RNA. In this case the stimulation of antibodies to DNA appeared to represent the adjuvant property of poly I ˙ poly C. Since non-tolerant but not tolerant mice had stimulation of antibodies to RNA with 10 pg poly I ˙ poly C, this anti-RNA acceleration appears to represent antigenic stimulation. All animals given 150 pg poly I ˙ poly C had stimulation of antibodies to both RNA and DNA, suggesting a predominently adjuvant mechanism. The possible role of antigenic and adjuvant properties of nucleic acids in the natural disease of New Zealand mice is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MICE as laboratory animals
KW  - IMMUNOGLOBULINS
KW  - RNA
KW  - DNA
KW  - AUTOANTIBODIES
KW  - INTERFERON inducers
KW  - BIOMOLECULES
N1  - Accession Number: 14545706; Powell, Deborah E. 1 Steinberg, A. D. 2; Affiliation:  1: Department of Pathology, Georgetown University Medical Center, Washington, D.C.  2: Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov72, Vol. 12 Issue 3, p419; Subject Term: MICE as laboratory animals; Subject Term: IMMUNOGLOBULINS; Subject Term: RNA; Subject Term: DNA; Subject Term: AUTOANTIBODIES; Subject Term: INTERFERON inducers; Subject Term: BIOMOLECULES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Huffman, D. H.;
AU  - Benjamin, R. S.;
AU  - Bachur, N. R.;
T1  - Daunorubicin metabolism in acute nonlymphocytic leukemia
CT  - Daunorubicin metabolism in acute nonlymphocytic leukemia
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1972/11/01/
VL  - 13
IS  - Nov-Dec
SP  - 895
EP  - 905
SN  - 00099236
AD  - Biochemistry Section, Baltimore Cancer Research Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-1969; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 26; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2  - The pharmacokinetic evaluation of daunorubicin (daunomycin) and its principal human metabolites, daunorubicinol and 2 previously unidentified metabolites, has provided information concerning the in vivo metabolism of daunorubicin in patients with acute nonlymphocytic leukemia. Daunorubicinol was the major fluorescent material present in plasma and urine and was a significant metabolite in the tissues. For 8 patients, the mean plasma half-lives of daunorubicin and daunorubicinol were 18.5 4.86 hours and 26.7 12.8 hours, respectively. In 4 of these patients the plasma half-lives of daunorubicin and daunorubicinol were equal, indicating a variability of the pharmacokinetics in different individuals. These observations together with the earlier demonstration of increased production of daunorubicinol in vitro by leukemic leukocytes from responding patients indicate a significant role for daunorubicinol in the pharmacodynamics of daunorubicin therapy. One of the new metabolites, D5, was the predominant fluorescent material in human heart.
KW  - Daunomycin--pharmacokinetics-;
KW  - Antineoplastic agents--daunomycin--pharmacokinetics, in acute nonlymphocytic leukemia patients;
KW  - Metabolism--daunomycin--half-life, blood levels, in acute nonlymphocytic leukemia patients;
KW  - Blood levels--daunomycin--half-life, in acute nonlymphocytic leukemia patients;
KW  - Half-life--daunomycin--blood levels, in acute nonlymphocytic leukemia patients;
KW  - Pharmacokinetics--daunomycin--blood levels and half-life, in acute nonlymphocytic leukemia patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Song, C. S.;
AU  - Gelb, N. A.;
AU  - Wolff, S. M.;
T1  - Influence of pyrogen-induced fever on salicylamide metabolism in man
CT  - Influence of pyrogen-induced fever on salicylamide metabolism in man
JO  - J. Clin. Invest.
JF  - J. Clin. Invest.
Y1  - 1972/11/01/
VL  - 51
IS  - Nov
SP  - 2959
EP  - 2966
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 10-3746; Language: English; Chemical Name: Salicylamide--65-45-2; References: 43; Journal Coden: JCINAOJONAO; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Marcia S. Jacinto
N2  - Salicylamide metabolism was studied in 18 normal volunteers (14 men, 4 women) before and after induction of artificial fever by administration of etiocholanolone or endotoxin. There was a significant reduction in the half-life of the excretion of the drug metabolites, probably due to increased hepatic and renal blood flow during episodes of pyrogen-induced fever. No simple explanation exists to account for the altered pattern of urinary salicylamide metabolites, wherein there is a proportionate decrease in the major metabolite (salicylamide glucuronide) with a concomitant increase in the proportion of one or both of the other metabolites (salicylamide sulfate and gentisamide glucuronide). These metabolic effects are attributed to the multiple, complex interactions between the effects of pyrogens, fever, or certain physiological or bichemical changes associated with them on the one hand, and the factors affecting the hepatic metabolism of salicylamide on the other.
KW  - Salicylamide--metabolism-;
KW  - Half-life--salicylamide--decreased, by pyrogen induced fever, in humans;
KW  - Metabolism--salicylamide--effects, pyrogen induced fever, in humans;
KW  - Excretion--salicylamide--effects, pyrogen induced fever, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Robbins, Jay H.
AU  - Levis, William R.
AU  - Miller, A. Edgar
T1  - XERODERMA PIGMENTOSUM EPIDERMAL CELLS WITH NORMAL UV-INDUCED THYMIDINE INCORPORATION.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1972/11//
VL  - 59
IS  - 5
M3  - Article
SP  - 402
EP  - 408
SN  - 0022202X
AB  - Ultraviolet light-induced thymidine incorporation was measured in trypsin-dissociated epidermal cells from two patients with xeroderma pigmentosum (XP) and from control donors. Results paralleled those obtained with lymphocytes and fibroblasts in that the patient with a repair defect in these cells also had the defect in her epidermal cells. The other patient, previously shown to have no detectable repair defect in his lymphocytes or fibroblasts, appeared also to have normal DNA repair in his epidermal cells despite the presence of severe clinical manifestations of XP in this tissue. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - XERODERMA pigmentosum
KW  - PHOTOSENSITIVITY disorders
KW  - DENDRITIC cells
KW  - THYMIDINE
KW  - FIBROBLASTS
KW  - DNA
N1  - Accession Number: 12627528; Robbins, Jay H. 1 Levis, William R. 1 Miller, A. Edgar 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Source Info: Nov72, Vol. 59 Issue 5, p402; Subject Term: XERODERMA pigmentosum; Subject Term: PHOTOSENSITIVITY disorders; Subject Term: DENDRITIC cells; Subject Term: THYMIDINE; Subject Term: FIBROBLASTS; Subject Term: DNA; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12627528
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DB  - aph
ER  - 

TY  - JOUR
AU  - NEUFELD, ELIZABETH F.
AU  - SWEELEY, CHARLES C.
AU  - ROGERS, STANFIELD
AU  - FRIEDMANN, THEODORE
AU  - ROBLIN, RICHARD
T1  - Gene Therapy for Human Genetic Disease?
JO  - Science
JF  - Science
Y1  - 1972/11/10/
VL  - 178
IS  - 4061
M3  - Article
SP  - 648
EP  - 649
SN  - 00368075
N1  - Accession Number: 85138563; NEUFELD, ELIZABETH F. 1; SWEELEY, CHARLES C. 2; ROGERS, STANFIELD 3; FRIEDMANN, THEODORE 4; ROBLIN, RICHARD 5; Affiliations: 1: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Biochemistry, Michigan State University, East Lansing 48823; 3: Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830; 4: Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla 92037; 5: Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts 02114; Issue Info: 11/10/1972, Vol. 178 Issue 4061, p648; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FARLEY, C. AUSTIN
AU  - BANFIELD, WILLiAM G.
AU  - KASNIC JR., GEORGE
AU  - FOSTER, WALTER S.
T1  - Oyster Herpes-Type Virus.
JO  - Science
JF  - Science
Y1  - 1972/11/17/
VL  - 178
IS  - 4062
M3  - Article
SP  - 759
EP  - 760
SN  - 00368075
AB  - A herpes-type virus infection, the first to be found in an invertebrate animal, is reported in the oyster Crassostrea virginica. Intranuclear herpes-type viral inclusions were more prevalent in the oyster at elevated water temperatures of 280 to 30°C than at normal ambient temperatures of 18' to 20°C. The inclusions were associated with a lethal disease at the elevated temperatures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85138595; FARLEY, C. AUSTIN 1; BANFIELD, WILLiAM G. 2; KASNIC JR., GEORGE 2; FOSTER, WALTER S. 3; Affiliations: 1: National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Middle Atlantic Coastal Fisheries Center, Oxford Laboratory, Oxford, Maryland 21654; 2: National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20014; 3: Hatchet Cove, Friendship, Maine 04547; Issue Info: 11/17/1972, Vol. 178 Issue 4062, p759; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROWE, WALLACE P.
AU  - HARTLEY, JANET W.
AU  - BREMNER, THEODORE
T1  - Genetic Mapping of a Murine Leukemia Virus-Inducing Locus of AKR Mice.
JO  - Science
JF  - Science
Y1  - 1972/11/24/
VL  - 178
IS  - 4063
M3  - Article
SP  - 860
EP  - 862
SN  - 00368075
AB  - The chromosomal location of one of the two murine leukemia virusinducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-l-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-l locus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85138627; ROWE, WALLACE P. 1; HARTLEY, JANET W. 1; BREMNER, THEODORE 2; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Department of Botany, Howard University, Washington, D.C. 20001; Issue Info: 11/24/1972, Vol. 178 Issue 4063, p860; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Grenne, W. H.;
AU  - Wiernik, P. H.;
T1  - Candida endophthalmitis. Successful treatment in a patient with acute leukemia
CT  - Candida endophthalmitis. Successful treatment in a patient with acute leukemia
JO  - Am. J. Ophthalmol.
JF  - Am. J. Ophthalmol.
Y1  - 1972/12/01/
VL  - 74
IS  - Dec
SP  - 1100
EP  - 1102
AD  - National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland 21211
N1  - Accession Number: 10-3079; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 18; Journal Coden: AJOPAA; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Howard J. Robbins
N2  - A case of candida endophthalmitis is reported in a patient under treatment for acute leukemia; therapy with I.V. amphotericin B was successful despite the occurence of bone marrow relapse.
KW  - Amphotericin B--endophthalmitis-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kleinman, L. M.;
AU  - Tangrea, J. A.;
AU  - Hiranaka, P. K.;
T1  - Preparation and assay of 2,4-dinitrochlorobenzene in acetone
CT  - Preparation and assay of 2,4-dinitrochlorobenzene in acetone
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1972/12/01/
VL  - 29
IS  - Dec
SP  - 1041
EP  - 1042
SN  - 00029289
AD  - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-2878; Language: English; Trade Name: 1-Chloro-2,4-dinitrobenzene; Generic Name: 2,4-Dinitrochlorobenzene; Chemical Name: 2,4-Dinitrochlorobenzene--97-00-7; References: 6; Publication Type: Assay and quality control; Journal Coden: AJHPA9; Section Heading: Pharmaceutics
N2  - The preparation and assay of 2,4-dinitrochlorobenzene (1-chloro-2,4-dinitrobenzene) solution in acetone are discussed. The chemical is used in a quantitative measurement of cell mediated immune responses. A packaging system was developed to increase the shelf life of the solution to 6 months.
KW  - 2,4-Dinitrochlorobenzene--solutions-;
KW  - Analysis--2,4-dinitrochlorobenzene--solutions, in acetone, and preparation;
KW  - Packaging--2,4-dinitrochlorobenzene--solutions, in acetone, increases shelf life;
KW  - Stability--2,4-dinitrochlorobenzene--solutions, in acetone, shelf life increased by packaging system;
KW  - Formulations--2,4-dinitrochlorobenzene--solutions, in acetone, and analysis;
KW  - Storage--2,4-dinitrochlorobenzene--solutions, acetone, package increases shelf life;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T.;
AU  - Canellos, G. P.;
AU  - Moxley, J. H.;
T1  - Decade of combination chemotherapy of advanced Hodgkin's disease
CT  - Decade of combination chemotherapy of advanced Hodgkin's disease
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1972/12/01/
VL  - 30
IS  - Dec
SP  - 1495
EP  - 1504
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland
N1  - Accession Number: 11-2129; Language: English; Trade Name: Oncovin; Generic Name: Vincristine; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Prednisone--53-03-2 Procarbazine--671-16-9 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine, mechlorethamine, prednisone and procarbazine (10:00); AHFS Class: Antineoplastic agents procarbazine, mechlorethamine, prednisone and vincristine (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 35; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - A review of the various forms of combination therapy in the treatment of Hodgkin's disease over the last decade is presented. Combinations of vinca alkaloids, alkylating agents, prednisone and methotrexate were encouraging enough to lead to an expanded program substituting procarbazine for methotrexate. This combined drug program (mechlorethamine, Oncovin [vincristine], prednisone and procarbazine; MOPP) 9 years later has yielded results significantly different than those previously achieved with single agents. The results of this program and of several other studies employing combinations of effective drugs consistently show a higher rate of induction of complete remissions in patients with advanced Hodgkin's disease (80%) and prolongation of remission duration after all therapy is stopped (36 months). These results have been confirmed in several cooperative trials. Approximately 70% of the patients with Stages III and IV disease who achieved remission with combination chemotherapy, between 1964 and 1967, are alive at 5 and 6 years. Forty-one per cent of complete responders have remained continuously free of disease with no further treatment up to 6 years. The complete remission rate alone should not be used to judge the effectiveness of new treatment programs. These therapies should also be evaluated by their ability to produce a long disease-free interval when all therapy is stopped.
KW  - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW  - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW  - Prednisone--mechlorethamine, procarbazine, and vincristine-;
KW  - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW  - Methotrexate--Hodgkin's disease-;
KW  - Hodgkin's disease--combined therapy--review;
KW  - Antineoplastic agents--mechlorethamine, prednisone, procarbazine and vincristine--Hodgkin's disease, therapy, review;
KW  - Antineoplastic agents--vincristine, mechlorethamine, prednisone and procarbazine--Hodgkin's disease, therapy, review;
KW  - Antineoplastic agents--prednisone, mechlorethamine, procarbazine and vincristine--Hodgkin's disease, therapy, review;
KW  - Antineoplastic agents--procarbazine, mechlorethamine, prednisone and vincristine--Hodgkin's disease, therapy, review;
KW  - Antineoplastic agents--methotrexate--Hodgkin's disease, replacement with procarbazine in MOPP therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carbone, P. P.;
T1  - Non-Hodgkin's lymphoma: recent observations on natural history and intensive treatment
CT  - Non-Hodgkin's lymphoma: recent observations on natural history and intensive treatment
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1972/12/01/
VL  - 30
IS  - Dec
SP  - 1511
EP  - 1516
AD  - Building 10, Room 6B15, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-2131; Language: English; References: 19; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - A discussion of the etiology and chemotherapy of non-Hodgkin's lymphomas is presented. Included in this classification are lymphocytic, histiocytic, pleomorphic and Burkett's lymphomas. The disease is more likely to be advanced and present with extranodal involvement. The results of therapy depend on the cell type; histologic pattern, diffuse or nodular; and the type of involvement, nodal vs. extranodal. The results of intensive chemotherapy have significantly increased the proportion of complete responders and the duration of complete remissions as compared to single agents. Several new agents offer promise of other combination therapy programs.
KW  - Antineoplastic agents--lymphomas--non-Hodgkin's, etiology and therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P. S.;
T1  - Chemotherapeutic management of the hormone-secreting endocrine malignancies
CT  - Chemotherapeutic management of the hormone-secreting endocrine malignancies
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1972/12/01/
VL  - 30
IS  - Dec
SP  - 1616
EP  - 1626
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland
N1  - Accession Number: 11-2213; Language: English; Chemical Name: Mitotane--53-19-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin (10:00); AHFS Class: Antineoplastic agents mitotane; References: 84; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - A review of the medical management of metastatic endocrine tumors, including clinical results of streptozotocin in malignant insulinomas and mitotane in adrenocortical carcinomas is presented. Use of both antineoplastic agents and antihormonal agents are included. The former is directed against the primary tumor and its metastases, while the latter offers palliation through the inhibition of synthesis, release, or direct cellular action of the specific secretory product.
KW  - Mitotane--carcinomas-;
KW  - Streptozotocin--insulinomas-;
KW  - Antineoplastic agents--streptozotocin--insulinomas, malignant, therapy, review;
KW  - Antineoplastic agents--mitotane--carcinomas, adrenocortical, therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Chused, T. M.
AU  - Steinberg, A. D.
AU  - Talal, N .
T1  - THE CLEARANCE AND LOCALIZATION OF NUCLEIC ACIDS BY NEW ZEALAND AND NORMAL MICE.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1972/12//
VL  - 12
IS  - 4
M3  - Article
SP  - 465
EP  - 476
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The clearance and localization of native DNA, denatured DNA, and doublestranded synthetic RNA was studied in New Zealand Black/White hybrid mice, which develop an illness closely resembling human systemic lupus erythematosus, a n d in normal mice. The three nucleic acids were rapidly cleared from the circulation in all strains studied. Serum nucleases did not account for this rapid clearance, indicating that the nucleic acids were taken up as macromolecules. The polymers were concentrated in the liver and spleen, suggesting uptake by the reticulo-endothelial system. Animals with circulating antibody cleared the nucleic acids even more rapidly. New Zealand mice did not differ from normal mice in their metabolism of nucleic acids. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - RNA
KW  - METABOLISM
KW  - MICE as laboratory animals
KW  - NUCLEIC acids
KW  - BIOCHEMISTRY
N1  - Accession Number: 14541942; Chused, T. M. 1 Steinberg, A. D. 2 Talal, N . 3; Affiliation:  1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.  2: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland.  3: Veterans Administration Hospital, University of California Medical Center, San Francisco, California 94121, U.S.A.; Source Info: Dec72, Vol. 12 Issue 4, p465; Subject Term: DNA; Subject Term: RNA; Subject Term: METABOLISM; Subject Term: MICE as laboratory animals; Subject Term: NUCLEIC acids; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kulin, H. E.;
AU  - Reiter, E. O.;
T1  - Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH
CT  - Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH
JO  - J. Clin. Endocrinol. Metab.
JF  - J. Clin. Endocrinol. Metab.
Y1  - 1972/12/01/
VL  - 35
IS  - Dec
SP  - 836
EP  - 839
AD  - Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
N1  - Accession Number: 10-2566; Language: English; Chemical Name: Ethinyl estradiol--57-63-6; Therapeutic Class: (68:16); AHFS Class: Estrogens ethinyl estradiol; References: 10; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Ethinyl estradiol in doses ranging from 8-50 mcg./day was given for one week in 16 different courses to 10 normal men. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in blood and urine by radioimmunoassay. Utilizing the 95% prediction interval, it was found that 32 mcg. and 42 mcg. suppressed FSH in urine respectively. Significant suppression of LH was not obtained. The results suggest that there is a differential suppressive effect upon FSH and LH by estrogen at threshold doses.
KW  - Ethinyl estradiol--effects-;
KW  - Estrogens--ethinyl estradiol--effects, low dose, on FSH and LH, in men;
KW  - Dosage--ethinyl estradiol--low, effects, on FSH and LH, in men;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MARX, S. J.
AU  - WOODARD, C. J.
AU  - AURBACH, G. D.
T1  - Calcitonin Receptors of Kidney and Bone.
JO  - Science
JF  - Science
Y1  - 1972/12//12/ 1/1972
VL  - 178
IS  - 4064
M3  - Article
SP  - 999
EP  - 1001
SN  - 00368075
AB  - Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon calcitonin accounts in part for the high biological potency in vivo of salmon calcitonin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85138675; MARX, S. J. 1; WOODARD, C. J. 1; AURBACH, G. D. 1; Affiliations: 1: Section on Mineral Metabolism, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 1/1972, Vol. 178 Issue 4064, p999; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hill, William G.
AU  - Silber, Stanley C.
T1  - Reciprocal aspects of mental health and family service.
JO  - Social Casework
JF  - Social Casework
Y1  - 1972/12//
VL  - 53
IS  - 10
M3  - Article
SP  - 623
EP  - 630
SN  - 00377678
AB  - A 1971 study of the relationships between 27 mental health centers and family service agencies indicates that benefits accrue when there are formal affiliations between the government and voluntary agencies. 14 notes.
KW  - FAMILY services
KW  - FAMILY social work
KW  - MENTAL health services
KW  - GOVERNMENT agencies
KW  - ASSOCIATIONS, institutions, etc.
KW  - MEDICAL care
KW  - MENTAL health
KW  - FEDERAL aid
KW  - FAMILIES
N1  - Accession Number: 15383529; Hill, William G. 1; Silber, Stanley C. 2; Affiliations: 1 : Professor, School of Social Work, University of Texas, Austin, Texas.; 2 : Chief, Community Support Program, National Institute of Mental Health, Rockville, Maryland.;  Source Info: Dec72, Vol. 53 Issue 10, p623; Historical Period: 1971; Subject Term: FAMILY services; Subject Term: FAMILY social work; Subject Term: MENTAL health services; Subject Term: GOVERNMENT agencies; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: MEDICAL care; Subject Term: MENTAL health; Subject Term: FEDERAL aid; Subject Term: FAMILIES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Bonavida, Benjamin
AU  - Fuchs, Sara
AU  - Sela, Michael
AU  - Roddy, Pamela W.
AU  - Sober, Herbert A.
T1  - Specific Antibodies to Dinucleotides and Trinucleotides.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1972/12/15/
VL  - 31
IS  - 3
M3  - Article
SP  - 534
EP  - 540
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Conjugates of the dinucleoside phosphates ApA, CpA, ApU and CpC (deliberately chosen so that an example of each of the purine-pyrimidine combinations be represented), and of the trinucleoside diphosphates ApApU and ApApC, with bovine serum albumin were used for immunization of rabbits. The specificity of the antibodies obtained was studied by the inhibition of binding of a radioiodinated antigen by different cross-reacting compounds, as well as by the sensitive modified bacteriophage technique. Antibodies of restricted specificity towards di- and trinucleotides were present in the respective homologous antisera. Antibodies to the trinucleoside diphosphates ApApU and ApApC recognize the complete hapten. Usually the nucleoside which is coupled to the protein carrier, and not the terminal one, forms the immunodominant portion of the antigenic determinant. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - NUCLEOTIDES
KW  - PYRIMIDINES
KW  - IMMUNE serums
KW  - HAPTENS
KW  - NUCLEIC acids
KW  - SERUM albumin
N1  - Accession Number: 12484295; Bonavida, Benjamin 1,2 Fuchs, Sara 1,2 Sela, Michael 1,2 Roddy, Pamela W. 1,2 Sober, Herbert A. 1,2; Affiliation:  1: Department of Chemical Immunology, Weizmann Institute of Science, Rehovot  2: Laboratory of Nutrition and Endocrinology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 1972, Vol. 31 Issue 3, p534; Subject Term: IMMUNOGLOBULINS; Subject Term: NUCLEOTIDES; Subject Term: PYRIMIDINES; Subject Term: IMMUNE serums; Subject Term: HAPTENS; Subject Term: NUCLEIC acids; Subject Term: SERUM albumin; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ROSENBERG, MORRIS
T1  - Using Social Data Archives.
JO  - Science
JF  - Science
Y1  - 1972/12/15/
VL  - 178
IS  - 4066
M3  - Article
SP  - 1193
EP  - 1194
SN  - 00368075
N1  - Accession Number: 85135735; ROSENBERG, MORRIS 1; Affiliations: 1: Laboratory of Socio-environmental Studies, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 12/15/1972, Vol. 178 Issue 4066, p1193; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bobrow, S. N.;
AU  - Jaffe, E.;
AU  - Young, R. C.;
T1  - Anuria and acute tubular necrosis associated with gentamicin and cephalothin
CT  - Anuria and acute tubular necrosis associated with gentamicin and cephalothin
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1972/12/18/
VL  - 222
IS  - Dec 18
SP  - 1546
EP  - 1547
AD  - Building 10, Room 12N226, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-2523; Language: English; Chemical Name: Cephalothin--153-61-7 Gentamicin--1403-66-3; Therapeutic Class: (8:12); AHFS Class: Antibiotics gentamicin (8:12); AHFS Class: Antibiotics cephalothin; References: 11; Publication Type: Brief Reports; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Joan Lentine
N2  - A patient developed acute tubular necrosis following treatment with cephalothin sodium and gentamicin sulfate. The patient was given cephalothin, 2 g. every 6 hours I.V., and gentamicin, 1 mg./kg. every 6 hr. I.V. for a total of 64 g. of cephalothin and 1.9 g. of gentamicin. Postmortem examination confirmed the clinical impression of acute tubular necrosis. No other cause for the renal failure was evident either clinically or at postmortem examination. It could not be determined in this case whether one of the antibiotics independently was responsible for the nephrotoxicity or whether there was a synergistic nephrotoxic effect of the combination.
KW  - Cephalothin--interactions-;
KW  - Gentamicin--interactions-;
KW  - Drug interactions--cephalothin and gentamicin--synergism, possible nephrotoxicity, in patient;
KW  - Antibiotics--gentamicin--interactions, cephalothin, synergism, possible nephrotoxicity, in patient;
KW  - Antibiotics--cephalothin--interactions, gentamicin, synergism, possible nephrotoxicity, in patient;
KW  - Drugs, adverse reactions--gentamicin--interactions, cephalothin, synergism, possible nephrotoxicity, in patient;
KW  - Drugs, adverse reactions--cephalothin--interactions, gentamicin, synergism, possible nephrotoxicity, in patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - WEISMAN, IRWIN D.
AU  - BENNETT, LAWRENCE H.
AU  - MAXWELL SR., LOUIS R.
AU  - WOODS, MARK W.
AU  - BURK, DEAN
T1  - Recognition of Cancer in vivo by Nuclear Magnetic Resonance.
JO  - Science
JF  - Science
Y1  - 1972/12/22/
VL  - 178
IS  - 4067
M3  - Article
SP  - 1288
EP  - 1290
SN  - 00368075
AB  - Pulsed nuclear magnetic resonance has been used to differentiate in vivo between normal mouse tail tissue and a malignant transplanted melanona, S91, located on the tail. The tumnor displayed a nuclear (proton) spin-lattice relaxation time of ~0.7 second contrasted with the simultaneolusly measured normal tail tissue relaxation time of ~0.3 second. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85135778; WEISMAN, IRWIN D. 1; BENNETT, LAWRENCE H. 1; MAXWELL SR., LOUIS R.; WOODS, MARK W. 2; BURK, DEAN 2; Affiliations: 1: Institute for Materials Research, National Bureau of Standards, Gaithersburg, Maryland 20760; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/22/1972, Vol. 178 Issue 4067, p1288; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOIME, H. AVIV I.
AU  - LOYD, B.
AU  - LEDER, P.
T1  - Translation of Bacteriophage Qβ Messenger RNA in a Murine Krebs 2 Ascites Tumor Cell-Free System.
JO  - Science
JF  - Science
Y1  - 1972/12/22/
VL  - 178
IS  - 4067
M3  - Article
SP  - 1293
EP  - 1295
SN  - 00368075
AB  - Qβ is a small bacterial virus whose three genes are encoded in a single-stranded molecule of RNA. This RNA serves directly as the Qβ message. Here we describe conditions under which RNA corresponding to the coat cistron of this bacterial virus is translated in a system derived from mammalian cells. Translation of the bacterial virus messenger RNA is less effective than that of mammalian globin messenger RNA, but is somewhat enhanced by mild alkali treatment of the messenger. The synthesized product when subjected to electrophoresis migrates with authentic Qβ coat protein and yields tryptic peptides that correspond to those derived from the Qβ coat protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85135781; BOIME, H. AVIV I. 1; LOYD, B. 1; LEDER, P. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 12/22/1972, Vol. 178 Issue 4067, p1293; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Goodwin, F. K.;
AU  - Post, R. M.;
AU  - Dunner, D. L.;
AU  - Gordon, E. K.;
T1  - Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique
CT  - Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1973/01/01/
VL  - 130
IS  - Jan
SP  - 73
EP  - 79
SN  - 0002953X
AD  - Laboratory of Clinical Science, Building 10, Room 4S-239, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-3943; Language: English; Chemical Name: Probenecid--57-66-9; Therapeutic Class: (40:40); AHFS Class: Uricosuric agents probenecid; References: 49; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: C. Robert Sturwold
N2  - The accumulation of 5-hydroxyindolacetic acid (I) and homovanillic acid (II) following high doses of probenecid (100 mg./kg./day) was studied in 38 patients with affective illness in order to assess the central amine function for both level and rate of change of biogenic amines. Besides the 38 moderately severe to severely depressed patients, 8 heroin addicts on methadone, and 8 normal controls participated in the study. All subjects except those on methadone were drug free for at least 2 weeks prior to the study. Diets were restricted to exclude foods affecting indoleamine and catecholamine metabolism. The metabolites accumulated were increased by administering precursors which increase amine synthesis and were decreased by administering specific inhibitors of amine synthesis. Compared with controls, depressed patients had low II accumulation (higher in bipolar than in unipolar patients) and addicts on methadone had low I accumulation.
KW  - Probenecid--effects-;
KW  - Uricosuric agents--probenecid--effects, metabolism, biogenic amines, in CSF, in depressed patients, and in methadone treated addicts;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Murphy, D. L.;
AU  - Goodwin, F. K.;
AU  - Brodie, K. H.;
AU  - Bunney, W. E.;
T1  - L-dopa, dopamine, and hypomania
CT  - L-dopa, dopamine, and hypomania
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1973/01/01/
VL  - 130
IS  - Jan
SP  - 79
EP  - 82
SN  - 0002953X
AD  - Building 10, Room 3S-229, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-3860; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 18; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: C. Robert Sturwold
N2  - A double-blind study was conducted to evaluate whether altered L-dopa (levodopa) metabolism might contribute to the development of hypomania in bipolar patients. With the use of levodopa and a placebo, 4 depressed patients without hypomanic episodes and 4 depressed patients with hypomanic episodes were treated for an average of 145 days. Three to seven 24-hr. urine samples were collected from each patient to measure urinary excretion of dopamine, Homovanillic acid (HVA), and unmetabolized levodopa. Patients who developed hypomania excreted more than twice the amount of dopamine and levodopa during levodopa treatment than the unipolar controls. The data suggest that the increased psychomotor activity observed during hypomania and mania might represent the behavioral effects of increased levels of dopamine formed from levodopa. Changes in dopamine metabolism are implicated in the development of hypomania and mania since the bipolar patients exhibited a differential sensitivity to the development of hypomania and mania during levodopa treatment.
KW  - Levodopa--metabolism-;
KW  - Antiparkinson agents--levodopa--metabolism, and hypomania, mechanism of action, in psychiatric patients;
KW  - Metabolism--levodopa--and hypomania, mechanism of action, in psychiatric patients;
KW  - Mechanism of action--levodopa--hypomania, in psychiatric patients;
KW  - Toxicity--levodopa--hypomania, mechanism, in psychiatric patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Rayner, Jeannette F.
T1  - Communication Between the Public and the Dental Profession.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/01//
VL  - 63
IS  - 1
M3  - Article
SP  - 21
EP  - 32
PB  - American Public Health Association
SN  - 00900036
AB  - How do dentists and para-dental workers view the public? And how accurate are these assessments? Based on a sample of such personnel, data were collected to see whether they could accurately judge public responses to selected dental health items. Findings are presented and discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Public health
KW  - Dental care
KW  - Dentist & patient
KW  - Dental personnel
KW  - Preventive dentistry
KW  - Dental students
KW  - Public opinion
N1  - Accession Number: 24294383; Rayner, Jeannette F. 1; Affiliations: 1: Public Health Analyst, Office of Social and Behavioral Analysis, Division of Dental Health, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Maryland, 20014; Issue Info: Jan1973, Vol. 63 Issue 1, p21; Thesaurus Term: Public health; Subject Term: Dental care; Subject Term: Dentist & patient; Subject Term: Dental personnel; Subject Term: Preventive dentistry; Subject Term: Dental students; Subject Term: Public opinion; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Wolf, Philip A.
AU  - Kannel, William B.
AU  - McNamara, Patricia M.
AU  - Gordon, Tavia
T1  - The Role of Impaired Cardiac Function in Atherothrombotic Brain Infarction: The Framingham Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/01//
VL  - 63
IS  - 1
M3  - Article
SP  - 52
EP  - 58
PB  - American Public Health Association
SN  - 00900036
AB  - Atherothrombotic main infarction (ABI) accounted for the majority of the 152 strokes in 5209 people in 16 years of follow-up in the Framingham Heart Disease epidemiology Study. Hypertension (systolic and diastolic) was the major risk factor in ABI, but findings indicate that cardiac abnormalities increase the risk of ABI over and above a blood pressure effect. Control of blood pressure and cardiac impairments likely to lessen occurrence of ABI. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Diseases
KW  - Cerebrovascular disease
KW  - Blood pressure
KW  - Hypertension
KW  - Blood circulation disorders
KW  - RISK factors
KW  - Diagnosis
KW  - Medical care
KW  - Framingham (Mass.)
KW  - Massachusetts
N1  - Accession Number: 24294389; Wolf, Philip A. 1; Kannel, William B. 2; McNamara, Patricia M. 2; Gordon, Tavia 3; Affiliations: 1: Assistant Professor, Neurology, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; 2: Heart Disease Epidemiology Study, Framingham, Massachusetts; 3: National Heart and Lung Institute, National Institutes of Health, Washington, D.C.; Issue Info: Jan1973, Vol. 63 Issue 1, p52; Thesaurus Term: Diseases; Subject Term: Cerebrovascular disease; Subject Term: Blood pressure; Subject Term: Hypertension; Subject Term: Blood circulation disorders; Subject Term: RISK factors; Subject Term: Diagnosis; Subject Term: Medical care; Subject: Framingham (Mass.); Subject: Massachusetts; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Torrey, E. Fuller
AU  - Smith, Debris
AU  - Wise, Harold
T1  - The Family Health Worker Revisited: A Five-Year Follow-up.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/01//
VL  - 63
IS  - 1
M3  - Article
SP  - 71
EP  - 74
PB  - American Public Health Association
SN  - 00900036
AB  - This paper describes the present position of family health workers who were trained and worked at a neighborhood health center during the past five years. Problems initially anticipated for such workers did not materialize but others have emerged: lack of self-esteem, lack of upward and lateral mobility, inadequate evaluation of the validity of their training and role, and to some extent paternalism. These are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Community health aides
KW  - Training
KW  - Medical centers
KW  - Self-esteem
KW  - Self-confidence
KW  - Paternalism
KW  - Bronx (New York, N.Y.)
KW  - New York (N.Y.)
KW  - New York (State)
N1  - Accession Number: 24294392; Torrey, E. Fuller 1; Smith, Debris 2; Wise, Harold; Affiliations: 1: Staff Member, New Careers Training Program and Special Assistant to the Director for International Activities, National Institute of Mental Health, Washington, D.C.; 2: Deputy Project Director, Martin Luther King, Jr. Health Center; Issue Info: Jan1973, Vol. 63 Issue 1, p71; Subject Term: Community health aides; Subject Term: Training; Subject Term: Medical centers; Subject Term: Self-esteem; Subject Term: Self-confidence; Subject Term: Paternalism; Subject: Bronx (New York, N.Y.); Subject: New York (N.Y.); Subject: New York (State); NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rich, R. R.;
AU  - Johnson, J. S.;
T1  - Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis
CT  - Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis
JO  - Arthritis and Rheumatism (USA)
JF  - Arthritis and Rheumatism (USA)
Y1  - 1973/01/01/
VL  - 16
IS  - Jan-Feb
SP  - 1
EP  - 9
SN  - 00043591
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Building 10-11N232, Bethesda, Maryland 20014
N1  - Accession Number: 10-2735; Language: English; References: 18; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology
N2  - Liver function was studied in patients with juvenile rheumatoid arthritis (JRA) who were treated with salicylates insoes sufficient to produce high serum levels. Salicylates were administered to 6 patients with juvenile rheumatoid arthritis in doses sufficient to produce a serum level in excess of 25 mg./100 ml. All 6 patients developed elevations of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. In addition, 4 patients had other evidence of hepatic dysfunction. Liver biopsies performed in 2 patients revealed a mononuclear cell infiltration. These dose related abnormalities were reversible. Routine liver function studies and serum salicylate levels should be made in patients receiving chronic high-dose salicylate therapy.
KW  - Salicylates--effects--liver function, rheumatoid arthritis, therapy, in children;
KW  - Toxicity--salicylates--effects, liver function, rheumatoid arthritis, therapy, in children;
KW  - Arthritis--salicylates--toxicity, hepatic, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Curtis, J. E.;
AU  - Sharp, J. T.;
AU  - Lidsky, M. D.;
AU  - Hersh, E. M.;
T1  - Immune response of patients with rheumatoid arthritis during cyclophosphamide treatment
CT  - Immune response of patients with rheumatoid arthritis during cyclophosphamide treatment
JO  - Arthritis and Rheumatism (USA)
JF  - Arthritis and Rheumatism (USA)
Y1  - 1973/01/01/
VL  - 16
IS  - Jan-Feb
SP  - 34
EP  - 42
SN  - 00043591
AD  - (Reprints: Department of Medicine, Princess Margaret Hospital, 500 Sherbourne Street, Toronto 5, Ontario, Canada
AD  - Collaborative Research Program, Transplantation Immunology Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
N1  - Accession Number: 10-3078; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 31; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2  - The immune responses of patients with rheumatoid arthritis are assessed and correlated with the clinical features of the disease. Eleven patients had been randomly assigned to receive cyclophosphamide, 50 to 75 mg./day, and 10 to receive a placebo. Immunologic responsiveness was assessed by delayed hypersensitivity skin testing, immunoglobulin levels, in vitro lymphocyte blastogenesis and the primary immune response. All patients had elevated levels of IgG, normal or low IgA, and IgM. Delayed hypersensitivity and in vitro lymphocyte blastogenic responses after immunization with the primary antigens, keyhole limpet hemocyanin and the amino acid copolymer (GLAT), were normal. Keyhole limpet hemocyanin and GLAT hemagglutinin titers were lower than normal due to decreased IgG and IgM formation. Treatment for 8 weeks with cyclophosphamide, 50 to 75 mg./day, did not alter the clinical status of the patients and had no detectable effect on immune reactivity.
KW  - Cyclophosphamide--arthritis-;
KW  - Antineoplastic agents--cyclophosphamide--arthritis, rheumatoid, effects, immune responses, in patients;
KW  - Arthritis--cyclophosphamide--rheumatoid, effects, immune responses, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Tauber, Stephen J
AU  - Werner, Franklin L
T1  - Information activities and services of the national cancer institue
JO  - Dhew Publ. No. (nih)74-543. Tr-73-1575-10. Contract No1-cn-35011. 1973 November 30. Informatics Inc., Information Sytems Company, 6000 Executive Boulevard, Rockville, Maryland. Xi + 106 P. 0 Ref
JF  - Dhew Publ. No. (nih)74-543. Tr-73-1575-10. Contract No1-cn-35011. 1973 November 30. Informatics Inc., Information Sytems Company, 6000 Executive Boulevard, Rockville, Maryland. Xi + 106 P. 0 Ref
Y1  - 1973///
M3  - Book Chapter
AB  - Describes more than 100 sources of information and publications within the national cancer institute. Listings include name, address, and telephone of the person to contact and also information regarding ordering and accessibility. Listings are classed under twelve general headings: primary publications, secondary publications, general technical publications, administrative publications, computerized data banks, libraries and manual data files, special collections and activities, task forces, seminars and symposia, workshops, conferences, and general information activities. An index provides access by subjects or by organizational units associated with the information activities.
N1  - Accession Number: ISTA0902399; Tauber, Stephen J 1; Werner, Franklin L; Affiliations: 1 : National Cancer Institute;  Source Info: 1973; Note: Update Code: 0900; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levy, R. I.;
AU  - Rifkind, B. M.;
T1  - Lipid lowering drugs and hyperlipidemia
CT  - Lipid lowering drugs and hyperlipidemia
JO  - Drugs (New Zealand)
JF  - Drugs (New Zealand)
Y1  - 1973/01/01/
VL  - 6
IS  - Jan
SP  - 12
EP  - 45
SN  - 00126667
AD  - Lipid Metabolism Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 11-1726; Language: English; References: 66; Journal Coden: DRUGAY; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Kenneth J. Bender
N2  - A review of hyperlipidemia and its treatment, with emphasis on the need to consider all lipoproteins rather than just plasma cholesterol, is presented. Five types of hyperlipoproteinemia are defined along with their mechanisms and management. Diet is discussed as well as drugs and correlations of the lipolipidemic agents and coronary heart disease are drawn.
KW  - Nutrition--diet--hyperlipidemia, therapy, review;
KW  - Antilipemic agents--hyperlipidemia--therapy, review;
KW  - Hyperlipidemia--antilipemic agents--and diet, therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Rhaese, Hans-Jürgen
AU  - Boetker, Naomi Kay
T1  - The Molecular Basis of Mutagenesis by Methyl and Ethyl Methanesulfonates.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1973/01//
VL  - 32
IS  - 1
M3  - Article
SP  - 166
EP  - 172
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The molecular basis of the biological effect of alkylation, mutation induction and inactivation, was studied using transforming DNA. Comparative studies of mutation induction after methylation (by methyl methanesulfonate) and ethylation (by ethyl methanesulfonate) showed that methylation was five to ten times more effective than ethylation. This observation confirms chemical studies of the reactivities of the individual bases of DNA but conflicts sharply with observations that methyl methanesulfonate is much less mutagenic than ethyl methanesulfonate in bacteriophage and some higher organisms. In each case the number of mutational events caused in transforming DNA followed single-hit kinetics. After termination of alkylation, the rates of decrease of mutants caused by methylation was twice that caused by ethylation, which fits chemical estimates of depurination rates. Reverse mutation studies with different mutagens and base analogs indicated that methyl methanesulfonate predominantly methylates guanine whereas ethyl methanesulfonate alkylates guanine and also adenine; in both cases the major product is an N7-alkyl purine. Accordingly the cause of base-pairing mistakes is unlikely to be related to stearic effects of the alkyl group but rather due to ionization of the alkylated guanine. In addition, inactivation of transforming activity was observed to be linear with treatment time of DNA with methyl or ethyl methanesulfonate in a semilogarithmic plot. Since the observed inactivation rates cannot be solely explained as inactivating mutagenic events produced by base alkylation, it is likely that phosphate alkylation is inactivating. Lethal and mutagenic DNA alterations are shown to be dissociated processes by the following observations. (a) After termination of alkylation, the number of mutants caused by alkylation of the purine bases decreased linearly with time indicating that depurination is inactivating. (b) Under identical conditions, the number of total transformants decreased three times faster than the number of mutants, indicating that in addition to depurination triester breaks must be responsible for inactivation. Therefore, base alkylations are mutagenic and depurination and triester breaks are lethal DNA alterations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - ALKYLATION
KW  - METHANESULFONATES
KW  - BIOMOLECULES
KW  - MUTAGENESIS
KW  - DNA damage
N1  - Accession Number: 13478548; Rhaese, Hans-Jürgen 1 Boetker, Naomi Kay 1; Affiliation:  1: Arbeitsgruppe Molekulare Genetik im Fachbereich Biologie, J. W. Goethe-Universität, Frankfurt a. M., and Laboratory of Molecular Biology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: 1973, Vol. 32 Issue 1, p166; Subject Term: DNA; Subject Term: ALKYLATION; Subject Term: METHANESULFONATES; Subject Term: BIOMOLECULES; Subject Term: MUTAGENESIS; Subject Term: DNA damage; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cosmides, G. J.;
T1  - Human variability and the safer, more effective use of drugs
CT  - Human variability and the safer, more effective use of drugs
JO  - Hosp. Formul. Manage.
JF  - Hosp. Formul. Manage.
Y1  - 1973/01/01/
VL  - 8
IS  - Jan
SP  - 7
EP  - 5
AD  - Pharmacology/Toxicology Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-4335; Language: English; References: 10; Journal Coden: HOFMAY; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Paul R. Webster
N2  - A discussion of the variability of humans anatomically, physiologically and biochemically and the effect on an individual's response to drugs is presented. The variation in any response to drugs caused by genetics, environment, or gene-environment interaction is discussed in detail. It is suggested that rational therapy can only be attained through a diligent awareness of the individuality of every human being. The planning of experimental investigations, the interpretation of results, and their application to the practical problems of life must always be viewed in this light.
KW  - Rational therapy--effects--pharmacogenetics, and environment, on individuals;
KW  - Pharmacogenetics--effects--on drug response, in individuals;
KW  - Drugs--effects--variability, due to genetics and environment;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4335&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Osborne, Harold F
T1  - Criticism and creativity
JO  - In Society For Technical Communication, Inc. Proceedings Of The 20th International Technical Communications Conference, Houston, Texas, May 9-12, 1973. P. 107-109. 0 Ref. See Isa 74-021/y
JF  - In Society For Technical Communication, Inc. Proceedings Of The 20th International Technical Communications Conference, Houston, Texas, May 9-12, 1973. P. 107-109. 0 Ref. See Isa 74-021/y
Y1  - 1973///
M3  - Book
AB  - The editorial function is similar to literary criticism in that it contributes to improvement in the quality of what is written and read. While the editor's function is little know outside the publishing professions, and is infrequently acknowledged as contributory, particularly by writersm it is positive and constructive, removal of traces of the writer's creative difficultyl adds style to the writer's work. Removal of excess wordage adds effectiveness and vigor. Qualities that characterize good writing can be added by a editor if they are not provided by the author. These processes are creative, in that they produce something that was not present previously. The creative satisfactions for editors are akin to those of writers.
N1  - Accession Number: ISTA0900204; Osborne, Harold F 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1973; Note: Update Code: 0900; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - Development of the autoclass system for automated creation and maintenance of hierarchical classifications
JO  - In Waldron, Helen J., Ed.; Long F. Raymond, Ed. Proceedings Of The American Society For Information Science. Volume 10. 36th Annual Meeting, Los Angeles, California, October 21-25, 1973. 1973. Greenwood Press, Westport, Connecticut. P. 205-206. 5 Ref. See
JF  - In Waldron, Helen J., Ed.; Long F. Raymond, Ed. Proceedings Of The American Society For Information Science. Volume 10. 36th Annual Meeting, Los Angeles, California, October 21-25, 1973. 1973. Greenwood Press, Westport, Connecticut. P. 205-206. 5 Ref. See
Y1  - 1973///
M3  - Book
AB  - The development of an automated system, autoclass, is described. It consists of three major processing programs which use simple punched card input to create complex print-ready records in indented hierarchical format. All programs are written in pl/i and are executed on a ibm 360 or 370 computer. Special features (stated) facilitate updating and permit wide latitude in format of both category numbers and text.
N1  - Accession Number: ISTA0901935; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland.;  Source Info: 1973; Note: Update Code: 0900; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cargille, C. M.;
AU  - Vaitukaitis, J. L.;
AU  - Bermudez, J. A.;
AU  - Ross, G. T.;
T1  - Differential effect of ethinyl estradiol upon plasma FSH and LH relating to time of administration in the menstrual cycle
CT  - Differential effect of ethinyl estradiol upon plasma FSH and LH relating to time of administration in the menstrual cycle
JO  - J. Clin. Endocrinol. Metab.
JF  - J. Clin. Endocrinol. Metab.
Y1  - 1973/01/01/
VL  - 36
IS  - Jan
SP  - 87
EP  - 94
AD  - Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
N1  - Accession Number: 11-3552; Language: English; Chemical Name: Ethinyl estradiol--57-63-6; References: 17; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Pharmacology
N2  - The hypothesis that orally administered exogenous estrogen might exert differing effects upon circulating levels of plasma follicle stimulating and luteinizing hormones depending upon the time of administration during the menstrual cycle was investigated in 7 volunteers. Ethinyl estradiol, (I) 100 mcg./day, was administered from days 9-18, counting the day of onset of menses as day 0. Plasma FSH and LH concentrations were compared to those from 7 untreated controls. FSH showed a transitory elevation, marked decline, and prominent rebound following cessation of I. LH showed a sustained elevation during I therapy, with a maximum elevation near midcycle. Maximal levels of FSH and LH, which occurred concomitantly in controls, were dissociated in 6 of 7 women receiving I. These results were contrasted to those observed when the same days 0-7 when suppression of both FSH and LH was noted without the occurrence of peaks during therapy. These results provide evidence that the effect of orally administered exogenous estrogen upon plasma gonadotropins varies with the time of administration in the menstrual cycle.
KW  - Ethinyl estradiol--effects-;
KW  - Dosage schedules--ethinyl estradiol--effects, endogenous hormone blood levels, time dependent, in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ungaro, P. C.;
AU  - Drake, W. P.;
AU  - Mardiney, M. R., Jr.;
T1  - Repetitive administration of BCG in prevention and treatment of spontaneous leukemia of AKR mice
CT  - Repetitive administration of BCG in prevention and treatment of spontaneous leukemia of AKR mice
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1973/01/01/
VL  - 50
IS  - Jan
SP  - 125
EP  - 128
SN  - 00278874
AD  - Section of Immunology and Cell Biology, National Cancer Institute Baltimore Cancer Research Centre, Baltimore, Maryland 21211
N1  - Accession Number: 11-0233; Language: English; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines; References: 15; Section Heading: Drug Evaluations
N2  - Female AKR mice were randomly grouped at 8 weeks of age and treated every 2nd week thereafter until 42 weeks of age with I.P. BCG or saline. BCG treatment increased the survival time but did not prevent the eventual onset of leukemia. The responses were dose related.
KW  - BCG vaccines--leukemias-;
KW  - Immunosuppressive agents--BCG vaccines--leukemias, therapy and prevention, in mice;
KW  - Dosage--BCG vaccines--leukemias, therapy and prevention, in mice;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0233&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - CHAP
ID  - 2004-15428-005
AN  - 2004-15428-005
AU  - Arenberg, David
ED  - Eisdorfer, Carl
ED  - Lawton, M. Powell
ED  - Eisdorfer, Carl, (Ed)
ED  - Lawton, M. Powell, (Ed)
T1  - Cognition and aging: Verbal learning, memory, problem solving, and aging.
T2  - The psychology of adult development and aging.
Y1  - 1973///
SP  - 74
EP  - 97
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2004-15428-005. Partial author list: First Author & Affiliation: Arenberg, David; National Institutes of Health, Gerontology Research Center, Section on Human Learning and Problem Solving, Baltimore, MD, US. Release Date: 20040726. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Major Descriptor: Aging; Cognition; Memory; Problem Solving; Verbal Learning. Minor Descriptor: Gerontology. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 24. 
AB  - Prior to 1960, the literature on cognition and aging could have been reviewed exhaustively in two chapters. Today, even a review of selected literature could reach book-length proportions. In this chapter, a comprehensive review will not be attempted. Instead, recent representative studies in verbal learning, memory, and problem solving will be reviewed to outline the developments in theory and research since the late fifties when two important syntheses of the available knowledge about cognition and aging were published. In this chapter, cognition is viewed as effectiveness in dealing with information. The chapter deals predominantly with the processes of registering, storing, and retrieving information and with manipulating information to solve a problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cognition
KW  - aging
KW  - gerontology
KW  - verbal learning
KW  - problem solving
KW  - memory
KW  - 1973
KW  - Aging
KW  - Cognition
KW  - Memory
KW  - Problem Solving
KW  - Verbal Learning
KW  - Gerontology
KW  - 1973
DO  - 10.1037/10044-005
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15428-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2004-15428-016
AN  - 2004-15428-016
AU  - Kramer, Morton
AU  - Taube, Carl A.
AU  - Redick, Richard W.
ED  - Eisdorfer, Carl
ED  - Lawton, M. Powell
ED  - Eisdorfer, Carl, (Ed)
ED  - Lawton, M. Powell, (Ed)
T1  - Patterns of use of psychiatric facilities by the aged: Past, present, and future.
T2  - The psychology of adult development and aging.
Y1  - 1973///
SP  - 428
EP  - 528
CY  - Washington, DC, US
PB  - American Psychological Association
N1  - Accession Number: 2004-15428-016. Partial author list: First Author & Affiliation: Kramer, Morton; National Institute of Mental Health, Biometry Branch, US. Release Date: 20040726. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Major Descriptor: Aging; Health Care Utilization; Health Service Needs; Prediction; Trends. Minor Descriptor: Community Services; Geriatric Patients; Mental Disorders; Mental Health; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 101. 
AB  - Presented in this chapter is a discussion of trends in patterns of use of various types of psychiatric facilities by the aged; predictions of future needs of mental health services for the aged; estimates of numbers of psychiatrists, psychologists, psychiatric nurses, and psychiatric social workers needed to care for persons with mental disorders relative to estimates of the available supply of such professionals in 1970, 1975, and 1980; and other areas of concern for planning of mental health, general health, and related services for the aged, such as community care of the aged with disabling conditions, hospitalization of the aged for all diseases and disabling conditions, and living arrangements of the aged. It is hoped that a consideration of these topics and of the questions they may suggest will help to define more clearly the role of psychology and psychologists not only in the actual delivery of medical, psychiatric, psychological, and related human services required to maintain and to improve the mental, physical, and social well-being of the aged, but also in the many activities on which the delivery of such services depends. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - trends
KW  - psychiatric facility use
KW  - aged
KW  - mental health services
KW  - future needs
KW  - prediction
KW  - 1973
KW  - Aging
KW  - Health Care Utilization
KW  - Health Service Needs
KW  - Prediction
KW  - Trends
KW  - Community Services
KW  - Geriatric Patients
KW  - Mental Disorders
KW  - Mental Health
KW  - Mental Health Services
KW  - 1973
DO  - 10.1037/10044-016
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15428-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41471-014
AN  - 2013-41471-014
AU  - Bandler, Bernard
T1  - Interprofessional collaboration in training in mental health.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/01//
VL  - 43
IS  - 1
SP  - 97
EP  - 107
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Bandler, Bernard, 157 Brattle Street, Cambridge, MA, US, 02138
N1  - Accession Number: 2013-41471-014. PMID: 4705922 Partial author list: First Author & Affiliation: Bandler, Bernard; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Centers; Community Mental Health Training; Mental Health Personnel; Minority Groups; Professional Networking. Minor Descriptor: Cooperation. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 11. Issue Publication Date: Jan, 1973. 
AB  - The mental health professions have much in common in knowledge and skills. This commonality is increased by the experiences of teams in community mental health centers, the advent of new careerists, and work with minority cultures. The suggestion is advanced for experiments in interprofessional collaboration in training in both the curriculum and practicum. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - interprofessional collaboration
KW  - mental health training
KW  - community mental health centers
KW  - minority cultures
KW  - mental health professions
KW  - 1973
KW  - Community Mental Health Centers
KW  - Community Mental Health Training
KW  - Mental Health Personnel
KW  - Minority Groups
KW  - Professional Networking
KW  - Cooperation
KW  - 1973
DO  - 10.1111/j.1939-0025.1973.tb00789.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41471-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41471-018
AN  - 2013-41471-018
AU  - Shore, Milton F.
AU  - Massimo, Joseph L.
T1  - After ten years: A follow-up study of comprehensive vocationally oriented psychotherapy.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/01//
VL  - 43
IS  - 1
SP  - 128
EP  - 132
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-41471-018. PMID: 4705906 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Juvenile Delinquency; Male Delinquency; Psychotherapy; Remedial Education; Vocational Rehabilitation. Minor Descriptor: Community Services; Identity Formation; Personnel Placement. Classification: Criminal Behavior & Juvenile Delinquency (3236); Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jan, 1973. 
AB  - The third in a series of follow-up studies of adolescent delinquent boys successfully treated in a community-based program that combined job placement, remedial education, and psychotherapy shows significantly better overall adjustment in the treated group when compared with untreated controls. The lack of any major change in direction over a decade seems to confirm the significance for later development of identity formation during adolescence, and the need for priority to be given to innovative means of reaching adolescents during the crises that arise in that developmental period. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - vocationally oriented psychotherapy
KW  - adolescent delinquent boys
KW  - community based programs
KW  - job placement
KW  - remedial education
KW  - identity formation
KW  - 1973
KW  - Juvenile Delinquency
KW  - Male Delinquency
KW  - Psychotherapy
KW  - Remedial Education
KW  - Vocational Rehabilitation
KW  - Community Services
KW  - Identity Formation
KW  - Personnel Placement
KW  - 1973
DO  - 10.1111/j.1939-0025.1973.tb00793.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41471-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41471-026
AN  - 2013-41471-026
AU  - Huxley, Matthew
T1  - Review of Your money or your life: Rx for the medical marketplace.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/01//
VL  - 43
IS  - 1
SP  - 174
EP  - 175
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41471-026. Partial author list: First Author & Affiliation: Huxley, Matthew; Standards Development Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Health Care Services; Health Service Needs; Health Care Policy. Minor Descriptor: Neighborhoods; Prevention; Social Programs. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Kunnes, Riehard. Your money or your life: Rx for the medical marketplace=New York: Dodd, Mead. 205 pp. $5.95; 1972. Page Count: 2. Issue Publication Date: Jan, 1973. 
AB  - Reviews the book, Your Money Or Your Life: Rx for the Medical Marketplace by Riehard Kunnes (1972). Briefly, in this book, the problem under discussion is the non-accountability, non-responsibility, and non-responsiveness of our health care non-system to the needs of all of the non-filthy rich of this richest country in the world. His solution, of course, lies in the establishment of consumer-health worker councils controlling the planning, budgeting, medical policies, personnel, and salaries of all health services organized into a network of neighborhood service units focusing on an aggressive outreach and prevention program. In the reviewer's opinion, the book desperately needs editing and proofing, which the publisher failed to require or supply; it is repetitive, it rambles it lacks coherence and continuity. And the final disaster is that it is dull the cardinal sin of any rallying manifesto which is what this tract clearly set out to be. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - medical marketplace
KW  - health services
KW  - medical policies
KW  - prevention programs
KW  - health service needs
KW  - neighborhood services
KW  - 1973
KW  - Health Care Services
KW  - Health Service Needs
KW  - Health Care Policy
KW  - Neighborhoods
KW  - Prevention
KW  - Social Programs
KW  - 1973
U2  - Kunnes, Riehard. (1972); Your money or your life: Rx for the medical marketplace; New York: Dodd, Mead. 205 pp. $5.95
DO  - 10.1037/h0097673
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41471-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Arseneau, J. C.;
AU  - Bagley, C. M.;
AU  - Anderson, T.;
AU  - Canellos, G. P.;
T1  - Hyperkalemia, a sequel to chemotherapy of Burkitt's lymphoma
CT  - Hyperkalemia, a sequel to chemotherapy of Burkitt's lymphoma
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1973/01/06/
VL  - 1
IS  - Jan 6
SP  - 10
EP  - 14
SN  - 00237507
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-2713; Language: English; Chemical Name: Allopurinol--315-30-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents allopurinol; References: 16; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2  - Hyperkalemia developing within 48 hours of chemotherapy was found in retrospective analysis in 5 of 22 evaluable cases of Burkitt's lymphoma in patients. Most patients had been receiving allopurinol. Clinical and animal studies suggest that hyperkalemia is related to sudden lysis of large volumes of tumor. Patients at serious risk were found to be those with large tumor masses and/or impairment of renal function. Close observation, parenteral hydration, and diuretic therapy, control of hyperuricemia, reduction of the initial dose of chemotherapy, and, if necessary, dialysis are suggested during the initial therapy of these high risk Burkitt's lymphoma patients.
KW  - Allopurinol--Burkitt's lymphoma-;
KW  - Solutions--irrigating--adverse reactions, hyperkalemia, in Burkitt's lymphoma patients;
KW  - Antineoplastic agents--allopurinol--Burkitt's lymphoma, therapy, in patients, hyperkalemia due to lysis with irrigating solutions;
KW  - Drugs, adverse reactions--solutions--irrigating, hyperkalemia, in Burkitt's lymphoma patients;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-2713&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carbone, P. P.;
T1  - Management with combination therapy
CT  - Management with combination therapy
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1973/01/08/
VL  - 223
IS  - Jan 8
SP  - 165
EP  - 166
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 10-2784; Language: English; Publication Type: Current Concepts in Cancer Number 40; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2  - Studies in which combination therapy has proven successful in treating Hodgkin's disease are discussed.
KW  - Combined therapy--antineoplastic agents--Hodgkin's disease, in patients, discussion;
KW  - Antineoplastic agents--combined therapy--Hodgkin's disease, in patients, discussion;
KW  - Hodgkin's disease--antineoplastic agents--combined therapy, in patients, discussion;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-2784&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Freedman, Murray H.
AU  - Lyerla Jr., James R.
AU  - Chaiken, Irwin M.
AU  - Cohen, Jack S.
T1  - Carbon-13 Nuclear-Magnetic-Resonance Studies on Selected Amino Acids, Peptides, and Proteins.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1973/01/15/
VL  - 32
IS  - 2
M3  - Article
SP  - 215
EP  - 226
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Natural abundance high-resolution carbon-13 Fourier transform nuclear magnetic resonance (13C NMR) studies at 25 MHz have been carried out on selected amino acids, linear peptides and proteins. The pH dependence of the 13C resonances has been studied in detail in several cases. For L-histidine, the 13C chemical shifts of all six carbon atoms are sensitive to the ionization state of the titrating carboxyl, imidazole and amino groups. The data for each carbon resonance have been computer-fitted to a sum of three theoretical curves based on a simple proton-association equilibrium for each transition. The extent of chemical shift change upon ionization of a nearby group has been interpreted in terms of two competing effects, inductive (through-bond) and electric field (through-space) effects. The 13C NMR spectra of the amino-terminal 1–13, 1–15, and 1–20 peptides of bovine pancreatic ribonuclease A have been analyzed. Detailed resonance assignments have been made based on comparisons with the results for the free amino acids, shift effects for amino acids in small peptides, internal peptide bond effects and differences in amino acid composition. There is considerable correspondence between the observed 13C chemical shifts of these peptides and those predicted from the shifts of the component amino acids. Proteins of varying molecular weight have been studied to evaluate the potential of 13C NMR investigations of structure and conformation. A comparison has been made between the 13C NMR spectra of hen egg-white lysozyme in its native and reduced states. The spectrum of the fully reduced species appears to be well represented by the sum of the spectra of the individual amino acids, both in chemical shift and line width, whereas that for the native form exhibits consistently broader resonances. Similar results were obtained for ribonuclease A. At the current level of resolution, it is impossible to discern whether this line broadening derives from shorter relaxation time effects due to restricted motion, chemical shift non-equivalence between the same chemical groups, or both. However, it does appear that there are separately resolved peaks corresponding to Cβ-carbons for different threonyl residues, as well as for the C-4 ring carbons of the several tyrosyl residues in native hen egg-white lysozyme. Spectra of carbonic anhydrases (Mr ≈ 30000), which lack disulphide bonds, showed somewhat poorer resolution than the smaller proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEAR magnetic resonance
KW  - MAGNETIC resonance
KW  - AMINO acids
KW  - PEPTIDES
KW  - PROTEINS
KW  - RESEARCH
N1  - Accession Number: 12485129; Freedman, Murray H. 1 Lyerla Jr., James R. 1 Chaiken, Irwin M. 1 Cohen, Jack S. 1; Affiliation:  1: Faculty of Pharmacy, University of Toronto, Laboratory of Chemical Biology, National Institute of Arthritis and Metabolic Diseases, and Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland; Source Info: 1973, Vol. 32 Issue 2, p215; Subject Term: NUCLEAR magnetic resonance; Subject Term: MAGNETIC resonance; Subject Term: AMINO acids; Subject Term: PEPTIDES; Subject Term: PROTEINS; Subject Term: RESEARCH; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KREUZ, DAVID S.
AU  - AXETLROD, JULIus
T1  - Delta-9-Tetrahydrocannabinol: Localization in Body Fat.
JO  - Science
JF  - Science
Y1  - 1973/01/26/
VL  - 179
IS  - 4071
M3  - Article
SP  - 391
EP  - 393
SN  - 00368075
AB  - [141C]Δ9-Tetrahydrocannabinol (Δ9THC) was injected subcutaneously in rats every day for I to 26 days. Concentrations of Δ9THC and its mnetabolites, 11 -hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Δ9THC in fat was ten times greater than in any other tissiue examnined, and persisted in this tissue for 2 weeks. With repeated injection, A9THC and its metabolites accumulated in fat and brain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85135893; KREUZ, DAVID S. 1; AXETLROD, JULIus 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health. Bethe.sda, Maryland 20014; Issue Info: 1/26/1973, Vol. 179 Issue 4071, p391; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
AU  - Schooler, Carmi
T1  - OCCUPATIONAL EXPERIENCE AND PSYCHOLOGICAL FUNCTIONING: AN ASSESSMENT OF RECIPROCAL EFFECTS.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1973/02//
VL  - 38
IS  - 1
M3  - Article
SP  - 97
EP  - 118
SN  - 00031224
AB  - The central issue of this paper is whether men's adult occupational experiences affect or only reflect their psychological functioning. Our analysis isolates a small set of occupational conditions, twelve in all, which defines the structural imperatives of the job. These occupational conditions are found to be substantially related to men's psychological functioning, off as well as on the job. We argue that the relationships between occupational conditions and psychological functioning result from a continuing interplay between job and man, in which the effects of job on man are far from trivial. This argument is borne out by an assessment of the reciprocal effects of the substantive complexity of the work (a critically important occupational condition, for which we have the requisite longitudinal data) and several facets of psychological functioning. Substantive complexity has a decidedly greater impact on psychological functioning than the reverse. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAN-woman relationships
KW  - PROFESSIONAL relationships
KW  - OCCUPATIONAL prestige
KW  - PSYCHOLOGY
KW  - OCCUPATIONS
KW  - PROFESSIONAL practice
KW  - BEHAVIOR
N1  - Accession Number: 14741183; Kohn, Melvin L. 1; Schooler, Carmi 1; Affiliations: 1 : National Institute of Mental Health.;  Source Info: Feb73, Vol. 38 Issue 1, p97; Historical Period: 1964 to 1971; Subject Term: MAN-woman relationships; Subject Term: PROFESSIONAL relationships; Subject Term: OCCUPATIONAL prestige; Subject Term: PSYCHOLOGY; Subject Term: OCCUPATIONS; Subject Term: PROFESSIONAL practice; Subject Term: BEHAVIOR; Number of Pages: 22p; Document Type: Article
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DB  - ahl
ER  - 

TY  - JOUR
TY  - GEN
AU  - Blaschke, T. F.;
AU  - Elin, R. J.;
AU  - Berk, P. D.;
AU  - Song, C. S.;
AU  - Wolff, S. M.;
T1  - Effect of induced fever on sulfobromophthalein kinetics in man
CT  - Effect of induced fever on sulfobromophthalein kinetics in man
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1973/02/01/
VL  - 78
IS  - Feb
SP  - 221
EP  - 226
SN  - 00034819
AD  - Metabolism Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4N117, Bethesda, Maryland 20014
N1  - Accession Number: 10-2891; Language: English; Chemical Name: Sulfobromophthalein--297-83-6; Therapeutic Class: (36:00); AHFS Class: Diagnostic agents sulfobromophthalein; References: 23; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology
N2  - The effect of fever induced by endotoxin or etiocholanolone on sulfobromophthalein (BSP) kinetics was examined in 20 healthy volunteers by analyzing the plasma disappearance curves obtained after a single injection of 5.0 mg./kg. of BSP during the fever. In addition to 45-minute retention, BSP clearances, the values for the parameters of a compartmental model of BSP metabolism, and relative hepatic BSP storage capacity were calculated by computer from the experimental curves. Although only 9 of the 20 fever volunteers had abnormal BSP retention at 45 minutes, all pyrogen treated subjects had significant changes in values for the compartmental parameters. The largest changes were in the values of BSP reflux from liver to plasma, which increased to 587% of control values, and for relative hepatic BSP storage capacity, which fell by 46%. These results indicate that caution must be used in interpreting the BSP test in patients who are even mildly febrile.
KW  - Sulfobromophthalein--blood levels-;
KW  - Diagnostic agents--sulfobromophthalein--blood levels, changed by pyrogen induced fever, in humans;
KW  - Pharmacokinetics--sulfobromophthalein--blood levels, changed by pyrogen induced fever, in humans;
KW  - Tests--laboratory--sulfobromophthalein, changes, by pyrogen induced fever, in humans;
KW  - Metabolism--sulfobromophthalein--blood levels, changed, by pyrogen induced fever, in humans;
KW  - Blood levels--sulfobromophthalein--changes, by pyrogen induced fever, in humans;
KW  - Fever--effects--sulfobromophthalein, changes, blood levels, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Martin, W. R.;
AU  - Jasinski, D. R.;
AU  - Haertzen, C. A.;
AU  - Kay, D. C.;
AU  - Jones, B. E.;
AU  - \ET/;
T1  - Methadone\M/a reevaluation
CT  - Methadone\M/a reevaluation
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1973/02/01/
VL  - 28
IS  - Feb
SP  - 286
EP  - 295
AD  - National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky
N1  - Accession Number: 10-5085; Language: English; Chemical Name: Methadone--76-99-3; References: 36; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - Two double-blind studies using single doses of methadone hydrochloride and chronic methadone administration determined and compared the physiological changes in illicit narcotic users. Single doses of 10 mg. and 20 mg. produced subjective changes similiar to equipotent doses of morphine sulfate. Long-term daily usage of 100 mg. of oral methadone showed physical dependence comparable to injectable morphine, but a slower onset of abstinence syndrome. Sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution and edema emerged during the studies. The ability of methadone maintenance to block euphoria and to prevent the drug-seeking behavior was challenged by 4 mg. of I.V. hydromorphone hydrochloride (Dilaudid).
KW  - Methadone--dosage-;
KW  - Dosage--methadone--effects, in drug abusers;
KW  - Dependence--methadone--oral, compared to IV morphine dependence;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bagley, C. M.;
AU  - Bostick, F. W.;
AU  - DeVita, V. T.;
T1  - Clinical pharmacology of cyclophosphamide
CT  - Clinical pharmacology of cyclophosphamide
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1973/02/01/
VL  - 33
IS  - Feb
SP  - 226
EP  - 233
SN  - 00085472
AD  - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-3570; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 30; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Pharmacology; Abstract Author: Thomas E. O'Brien
N2  - The human pharmacology of labeled cyclophosphamide, was investigated in 26 patients. Methods for determining the half-life, excretion and metabolism are outlined. The use of this drug in non-neoplastic diseases is discussed.
KW  - Cyclophosphamide--metabolism-;
KW  - Antineoplastic agents--cyclophosphamide--metabolism, half-life and excretion, in patients;
KW  - Half-life--cyclophosphamide--and metabolism, in patients;
KW  - Metabolism--cyclophosphamide--half-life, and excretion, in patients;
KW  - Excretion--cyclophosphamide--and metabolism, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kennell, William B.
AU  - Shurtleff, Dewey
T1  - Cigarettes and the development of intermittent claudication.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1973/02//
VL  - 28
IS  - 2
M3  - Article
SP  - 61
EP  - 68
SN  - 0016867X
N1  - Accession Number: 17525029; Kennell, William B. 1; Shurtleff, Dewey 1; Source Information: Feb1973, Vol. 28 Issue 2, p61; Number of Pages: 8p; Illustrations: 7 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 3487
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Thompson, W. O.;
AU  - Christian, S. T.;
T1  - Calculating rate constants in forward drug transfer reactions (in vitro model cells)
CT  - Calculating rate constants in forward drug transfer reactions (in vitro model cells)
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1973/02/01/
VL  - 62
IS  - Feb
SP  - 328
EP  - 330
SN  - 00223549
AD  - National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky 40507
N1  - Accession Number: 12-0088; Language: English; Journal Coden: JPMSAE; Section Heading: Pharmaceutics
KW  - Drugs--transfer--rate constants, calculation, in vitro model cells;
KW  - Rate constants--drugs--transfer, in vitro model cells;
KW  - Models--drugs--transfer, calculation of rate constants;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - EVARTS, EDWARD V.
T1  - Motor Cortex Reflexes Associated with Learned Movement.
JO  - Science
JF  - Science
Y1  - 1973/02/02/
VL  - 179
IS  - 4072
M3  - Article
SP  - 501
EP  - 503
SN  - 00368075
AB  - In primates, sensory input can generate reflex motor cortex output in association with learned movement when the sensory input has a strong and direct connection to the motor cortex-for example, when a stimulus calling for repositioning of the hand consists of a perturbation of hand position. This finding supports the proposal that neurons of primate motor cortex may function in a transcortical servo-loop. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85135935; EVARTS, EDWARD V. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health. National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 2/1973, Vol. 179 Issue 4072, p501; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SIGGINS, G. R.
AU  - BATTENBERG, E. F.
AU  - HOFFER, B. J.
AU  - BLOOM, F. E.
AU  - STEINER, A. L.
T1  - Noradrenergic Stimulation of Cyclic Adenosine Monophosphate in Rat Purkinje Neurons: An Immunocytochemical Study.
JO  - Science
JF  - Science
Y1  - 1973/02/09/
VL  - 179
IS  - 4073
M3  - Article
SP  - 585
EP  - 588
SN  - 00368075
AB  - A specific immunofluorescent histochemical method for cyclic adenosine monophosphate was used to study rat cerebellum. After topical treatment with norepinephrine or stimulation of norepinephrine-containing afferents from locus coeruleus, there was a striking increase in the number of Purkinje cells with strong cyclic adenosine monophosphate reactivity. Other putative inhibitory transmitters had no significant effect on staining of Purkinje cells. The results provide the first histochemical support for the hypothesis that cyclic adenosine monophosphate can be generated postsynaptically in central neurons in response to noradrenergic stimuli [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85135977; SIGGINS, G. R. 1; BATTENBERG, E. F. 1; HOFFER, B. J. 1; BLOOM, F. E. 1; STEINER, A. L. 2; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C.; 2: Department of Medicine, Albany Medical College, Albany, New York; Issue Info: 2/ 9/1973, Vol. 179 Issue 4073, p585; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KIES, MARIAN W.
AU  - DRISCOLL, BERNARD F.
AU  - SEIL, FREDRICK J.
AU  - ALVORD JR., ELLSWORTH C.
T1  - Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis.
JO  - Science
JF  - Science
Y1  - 1973/02/16/
VL  - 179
IS  - 4074
M3  - Article
SP  - 689
EP  - 690
SN  - 00368075
AB  - Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum." [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158281; KIES, MARIAN W. 1; DRISCOLL, BERNARD F. 1; SEIL, FREDRICK J. 2; ALVORD JR., ELLSWORTH C. 3; Affiliations: 1: Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Neurology, Stanford University School of Medicine, and Veterans Administration Hospital, Palo Alto, California 94304; 3: Department of Pathology, University of Washington School of Medicine, Seattle 98195; Issue Info: 2/16/1973, Vol. 179 Issue 4074, p689; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Peele, R.;
AU  - Von Loetzen, I. S.;
T1  - Phenothiazine deaths: a critical review
CT  - Phenothiazine deaths: a critical review
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1973/03/01/
VL  - 130
IS  - Mar
SP  - 306
EP  - 309
SN  - 0002953X
AD  - Area D Community Mental Health Center of Saint Elizabeths Hospital, National Institute of Mental Health, Washington, D. C. 20032
N1  - Accession Number: 10-4493; Language: English; References: 17; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity
N2  - A comparison of the sudden, unexplained deaths attributed to phenothiazines with those of sudden, unexplained deaths attributed to lethal catatonia is presented. To determine whether ""phenothiazine death'' is a valid entity, the authors examined case studies in the literature for other explanations of these sudden, unexpected, autopsy-negative deaths. The results of their comparisons of a large number of phenothiazine deaths and deaths due to lethal catatonia raise doubts as to the validity of phenothiazine death as an entity.
KW  - Phenothiazines--death--comparison, lethal catatonia, in patients;
KW  - Psychotherapeutic agents--phenothiazines--death, comparison, lethal catatonia, in patients;
KW  - Toxicity--phenothiazines--lack, on sudden death, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Chafetz, Morris E.
T1  - New Federal Legislation on Alcoholism--Opportunities and Problems.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/03//
VL  - 63
IS  - 3
M3  - Article
SP  - 206
EP  - 208
PB  - American Public Health Association
SN  - 00900036
AB  - Recognition of alcoholism as a complex problem involving medical, social and environmental factors is exemplified by new legislation for prevention, treatment and rehabilitation. Ways and means of implementing this legislation are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Environmental engineering
KW  - Liquor laws
KW  - Prevention of alcoholism
KW  - Drinking of alcoholic beverages
KW  - Alcoholics -- Legal status, laws, etc.
KW  - Federal legislation
KW  - Legislative bills
KW  - Social interaction
KW  - Ergonomics
KW  - United States
N1  - Accession Number: 24294427; Chafetz, Morris E. 1; Affiliations: 1: Director, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, Rockville, Maryland 20852; Issue Info: Mar1973, Vol. 63 Issue 3, p206; Thesaurus Term: Environmental engineering; Subject Term: Liquor laws; Subject Term: Prevention of alcoholism; Subject Term: Drinking of alcoholic beverages; Subject Term: Alcoholics -- Legal status, laws, etc.; Subject Term: Federal legislation; Subject Term: Legislative bills; Subject Term: Social interaction; Subject Term: Ergonomics; Subject: United States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 312140 Distilleries; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Winkler, J. W., Jr.;
AU  - Deisseroth, A. B.;
AU  - Morganroth, J.;
T1  - Quinidine hepatotoxicity?
CT  - Quinidine hepatotoxicity?
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1973/03/01/
VL  - 78
IS  - Mar
SP  - 460
SN  - 00034819
AD  - National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 10-3689; Language: English; Trade Name: Surfak; Generic Name: Dioctyl calcium sulfosuccinate; Chemical Name: Quinidine--56-54-2; Therapeutic Class: (56:12); AHFS Class: Cathartics dioctyl calcium sulfosuccinate (24:04); AHFS Class: Cardiac drugs quinidine; References: 4; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Judith A. Kepler
N2  - In 2 letters to the editor, the possiblity of an interaction between quinidine and dioctyl calcium sulfosuccinate (Surfak) resulting in hepatotoxicity is debated.
KW  - Quinidine--interactions-;
KW  - Dioctyl calcium sulfosuccinate--interactions-;
KW  - Cathartics--dioctyl calcium sulfosuccinate--interactions, quinidine, hepatotoxicity, discussion, in humans;
KW  - Cardiac drugs--quinidine--interactions, dioctyl calcium sulfosuccinate, hepatotoxicity, discussion, in humans;
KW  - Drug interactions--quinidine and dioctyl calcium sulfosuccinate--hepatotoxicity, discussion, in humans;
KW  - Drug interactions--dioctyl calcium sulfosuccinate and quinidine--hepatotoxicity, discussion, in humans;
KW  - Toxicity--quinidine--hepatotoxicity, possible interaction with dioctyl calcium sulfosuccinate, in humans;
KW  - Toxicity--dioctyl calcium sulfosuccinate--hepatotoxicity, possible interactions with quinidine, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kotin, J.;
AU  - Post, R. M.;
AU  - Goodwin, F. K.;
T1  - \D/\SU/9\BS/-Tetrahydrocannabinol in depressed patients
CT  - \D/\SU/9\BS/-Tetrahydrocannabinol in depressed patients
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1973/03/01/
VL  - 28
IS  - Mar
SP  - 345
EP  - 348
AD  - Reprints: Orange County Medical Center, 101 City Drive, Orange, California 92668
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 11-2120; Language: English; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants tetrahydrocannabinol; References: 17; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - A double-blind study on 8 depressed patients, who received oral \D/\SU/9\BS/ tetrahydrocannabinol at a dose of 0.3 mg./kg. 2 times a day for up to 7 days, failed to produce significant euphoria or an antidepressant response. Two patients experienced severe anxiety reactions with depersonalization after one dose and 2 others suffered adversities which lead to their early termination from the study. Four patients showed little change in mood but reported drowsiness.
KW  - Tetrahydrocannabinol--depression-;
KW  - Antidepressants--tetrahydrocannabinol--lack, effects, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Horton, J. E.
AU  - Oppenheim, J. J.
AU  - Mergenhagen, S. E.
T1  - ELABORATION OF LYMPHOTOXIN BY CULTURED HUMAN PERIPHERAL BLOOD LEUCOCYTES STIMULATED WITH DENTAL-PLAQUE DEPOSITS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1973/03//
VL  - 13
IS  - 3
M3  - Article
SP  - 383
EP  - 393
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Leucocyte cultures from subjects with periodontal disease when stimulated by human dental-plaque deposit material, or phytohaemagglutinin, produce a soluble factor, lymphotoxin, which is cytotoxic for fibroblasts in vitro. The cytotoxic effect was determined from the degree of inhibition of incorporation of 14C-labelled L-leucine by in vitro cultures of human gingival or mouse L-fibroblasts exposed to supernatants from such cultures. Inhibition of protein synthesis by the fibroblasts was not due to either depletion of nutrients or direct toxicity of the antigenic dental- plaque material. Both plaque-stimulated leucocyte culture supernatants from clinically normal subjects and unstimulated leucocyte culture supernatants from subjects with periodontal disease were significantly less inhibitory than super- natants of plaque-stimulated leucocyte cultures from subjects with periodontal disease. This production of lymphotoxin by leucocytes stimulated with antigen(s) present in dental plaque-deposits may reflect a mechanism of tissue destruction by sensitized lymphocytes present in the tissues of subjects with periodontal disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TUMOR necrosis factor
KW  - LEUCOCYTES
KW  - PERIODONTAL disease
KW  - BLOOD cells
KW  - FIBROBLASTS
KW  - KILLER cells
N1  - Accession Number: 14544572; Horton, J. E. 1 Oppenheim, J. J. 1 Mergenhagen, S. E. 1; Affiliation:  1: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1973, Vol. 13 Issue 3, p383; Subject Term: TUMOR necrosis factor; Subject Term: LEUCOCYTES; Subject Term: PERIODONTAL disease; Subject Term: BLOOD cells; Subject Term: FIBROBLASTS; Subject Term: KILLER cells; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cornelis, W. A.;
AU  - Christian, D. G.;
AU  - Fortner, C. L.;
T1  - Hodgkin's disease
CT  - Hodgkin's disease
JO  - J. Am. Pharm. Assoc.
JF  - J. Am. Pharm. Assoc.
Y1  - 1973/03/01/
VL  - NS13
IS  - Mar
SP  - 147
EP  - 154
AD  - Patient Care Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, U.S. Public Health Service Hospital, Baltimore, Maryland
N1  - Accession Number: 12-6205; Language: English; References: 6; Publication Type: Current Therapeutic Concepts; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Drucella Andersen
N2  - The pathology; staging; clinical course and complications; therapy, including radiation treatments and chemotherapy; and prognosis of Hodgkin's disease is presented.
KW  - Hodgkin's disease--therapy--discussion, in patients;
KW  - Radiation--Hodgkin's disease--chemotherapy, discussion, in patients;
KW  - Nomenclature--Hodgkin's disease--discussion;
KW  - Antineoplastic agents--Hodgkin's disease--therapy, discussion, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Layard, M. W. J.
T1  - Robust Large-Sample Tests for Homogeneity of Variances.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1973/03//
VL  - 68
IS  - 341
M3  - Article
SP  - 195
SN  - 01621459
AB  - Two asymptotically robust tests for equality of variances in the k-sample case are discussed: a simple x[sup t] test and a test based on the jackknife procedure. Some Monte Carlo experiments suggest that these tests are reasonably robust for moderately small samples, are more powerful than Box's grouping test and perform similarly to Bartlett's test in the normal case. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VARIANCES
KW  - MONTE Carlo method
KW  - DISTRIBUTION (Probability theory)
KW  - MATHEMATICAL statistics
KW  - ROBUST statistics
KW  - HOMOSCEDASTICITY
KW  - SAMPLE size (Statistics)
KW  - JACKKNIFE (Statistics)
KW  - HOMOGENEITY
N1  - Accession Number: 4606320; Layard, M. W. J. 1; Affiliations: 1: Senior Staff Fellow, Mathematical Statistics Section, National Cancer Institute, Bethesda, Maryland 20014.; Issue Info: Mar1973, Vol. 68 Issue 341, p195; Thesaurus Term: VARIANCES; Thesaurus Term: MONTE Carlo method; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MATHEMATICAL statistics; Subject Term: ROBUST statistics; Subject Term: HOMOSCEDASTICITY; Subject Term: SAMPLE size (Statistics); Subject Term: JACKKNIFE (Statistics); Subject Term: HOMOGENEITY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Weisburger, J. H.;
AU  - Weisburger, E. K.;
T1  - Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids
CT  - Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids
JO  - Pharmacol. Rev.
JF  - Pharmacol. Rev.
Y1  - 1973/03/01/
VL  - 25
IS  - Mar
SP  - 1
EP  - 6
AD  - National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-0882; Language: English; References: 519; Journal Coden: PAREAQ; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - A review of the effects of aromatic and aliphatic hydroxylamines and hydroxamic acids on the hematopoietic system and their mutagenic, carcinogenic and toxic activities is presented. In vitro and enzymatic studies provide greater understanding and insight into the importance of amine metabolism and pathological properties.
KW  - Hydroxylamines--effects--hematopoietic system, and toxicity, in animals;
KW  - Hydroxamic acids--effects--hematopoietic system, and toxicity, in animals;
KW  - Toxicity--hydroxylamines--carcinogenicity, and mutation, in animals;
KW  - Toxicity--hydroxamic acids--carcinogenicity, and mutation, in animals;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2005-09606-001
AN  - 2005-09606-001
AU  - Rawlings, Robert R. Jr.
T1  - Comments on the Overall and Spiegel Paper.
JF  - Psychological Bulletin
JO  - Psychological Bulletin
JA  - Psychol Bull
Y1  - 1973/03//
VL  - 79
IS  - 3
SP  - 168
EP  - 169
CY  - US
PB  - American Psychological Association
SN  - 0033-2909
SN  - 1939-1455
AD  - Rawlings, Robert R. Jr., Health Service sand Mental Health Administration, National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20852
N1  - Accession Number: 2005-09606-001. Partial author list: First Author & Affiliation: Rawlings, Robert R. Jr.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Analysis of Variance. Classification: Psychometrics & Statistics & Methodology (2200). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 1973. Copyright Statement: American Psychological Association. 1973. 
AB  - Responds to the comments by J. F. Overall and D. K. Spiegel (see record [rid]1973-20070-001[/rid]) on the current author's original article 'Note on nonorthogonal analysis of variance' (see record [rid]1972-26084-001[/rid]). The purpose of this note is the clarification of certain erroneous interpretations concerning the nonorthogonal analysis of variance which appear in the comment by Overall and Spiegel. This note demonstrates that the method proposed by Overall and Spiegel and the method proposed by the current author are not equivalent. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nonorthogonal analysis of variance
KW  - 1973
KW  - Analysis of Variance
KW  - 1973
DO  - 10.1037/h0020025
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - GUIDOTTI, A.
AU  - COSTA, E.
T1  - Involvement of Adenosine 3',5'-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by Drugs.
JO  - Science
JF  - Science
Y1  - 1973/03/02/
VL  - 179
IS  - 4076
M3  - Article
SP  - 902
EP  - 904
SN  - 00368075
AB  - Immediately after the injection of reserpine (16 micromoles per kilogram, intraperitoneally), aminophylline (200 micromoles per kilogram, intraperitoneally), and carbamylcholine (8.2 micromoles per kilogram, intraperitoneally), the concentration of adenosine 3',5'-monophosphate in adrenal medulla of rats is increased severalfold. The three drugs also cause a delayed increase of medullary tyrosine hydroxylase activity. Our results are consistent with the view that an increase of medullary adenosine 3',5'-monophosphate concentration is involved in the drug-induced increase of tyrosine hydroxylase activity adrenal medulla. Experiments with tyramine (130 micromoles per kilogram intraperitoneally) suggest that the increase of tyrosine hydroxylase activity and of adenosine 3',5'-monophosphate concentrations is independent of an increase in adrenal catecholamine turnover rate. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158363; GUIDOTTI, A. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p902; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MILLER, A. L.
AU  - HAWKINS, R. A.
AU  - VEECH, R. L.
T1  - Phenylketonuria: Phenylalanine Inhibits Brain Pyruvate Kinase in vivo.
JO  - Science
JF  - Science
Y1  - 1973/03/02/
VL  - 179
IS  - 4076
M3  - Article
SP  - 904
EP  - 906
SN  - 00368075
AB  - The hypothesis that brain damage in phenylketonuria is related to inhibition of pyruvate kinase by phenylalanine was examined in rat brain in vivo. One hour after a single injection of phenylalanine into the rat, the brains were removed and completely frozen in less than a second. The concentration of phenylalanine in the brain was comparable to that found in phenylketonuric patients. Changes in brain glycolytic intermediates were consistent with inhibition of pyruvate kinase in vivo. The inhibition of pyruvate kinase was apparently compensated for by an increase in phosphoenolpyruvate; no decrease in adenosine triphosphate or creatine phosphate was found. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158364; MILLER, A. L. 1; HAWKINS, R. A. 1; VEECH, R. L. 1; Affiliations: 1: Section on Neurochemistry, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p904; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NAI-SHIN CHU
AU  - BLOOM, FLOYD E.
T1  - Norepinephrine-Containing Neurons: Changes in Spontaneous Discharge Patterns during Sleeping and Waking.
JO  - Science
JF  - Science
Y1  - 1973/03/02/
VL  - 179
IS  - 4076
M3  - Article
SP  - 908
EP  - 910
SN  - 00368075
AB  - Norepinephrine-containing neurons of the locus coeruleus of the cat were recorded with mnicroelectrodes during unrestrained sleeping and waking. The recorded neurons were subsequently defined by combined fluorescence histochemiiistry of catecholamnines and production of microlesions at recording sites. These pontine units show homtiogeneous changes in discharge patterns with respect to sleep stages, firing slowly during drowsy periods and slow wave sleep and firing in rapid bursts during paradoxical sleep. These data provide a direct correlation between the activity of defined catecholamiine-containing neurons and the spontaneous occurrence of sleep stages. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158366; NAI-SHIN CHU 1; BLOOM, FLOYD E. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p908; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WYATT, R. J.
AU  - MURPHY, D. L.
AU  - BELMAKER, R.
AU  - COHEN, S.
AU  - DONNELLY, C. H.
AU  - POLLIN, W.
T1  - Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia.
JO  - Science
JF  - Science
Y1  - 1973/03/02/
VL  - 179
IS  - 4076
M3  - Article
SP  - 916
EP  - 918
SN  - 00368075
AB  - Monoamine oxidase activity in blood platelets was measured, with [14C]tryptamine as substrate, in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers. The monoamine oxidase activity of both schizophrenic and nonschizophrenic co-twins was significantly lower than it was for the normals, and it was highly correlated between twins. In addition, there was a significant inverse correlation between a measure of the degree of the schizophrenic disorder and the monoamine oxidase activity. These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158371; WYATT, R. J. 1; MURPHY, D. L. 1; BELMAKER, R. 1; COHEN, S. 1; DONNELLY, C. H. 1; POLLIN, W. 1; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p916; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levine, A. S.;
AU  - Siegel, S. E.;
AU  - Schreiber, A. D.;
AU  - Hauser, J.;
AU  - Preisler, H.;
AU  - \ET/;
T1  - Protected environments and prophylactic antibiotics: a prospective controlled study of their utility in the therapy of acute leukemia
CT  - Protected environments and prophylactic antibiotics: a prospective controlled study of their utility in the therapy of acute leukemia
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1973/03/08/
VL  - 288
IS  - Mar 8
SP  - 477
EP  - 483
SN  - 00284793
AD  - Building 10, Room 6B06, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 10-3238; Language: English; Chemical Name: Gentamicin--1403-66-3 Vancomycin--1404-90-6 Nystatin--1400-61-9; References: 39; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2  - To reduce the frequency of infection in acute leukemia, an isolation and air filtration facility (protected environment) and a prophylactic regimen that included oral nonabsorbable antibiotics was instituted. Eighty-eight randomized patients received identical remission induction chemotherapy within one of 3 groups: protected environment combined with the prophylactic regimen (group 1); oral nonabsorbable antibiotics alone (group 2); and neither isolation nor prophylaxis (group 3). Antibiotics used were gentamicin, vancomycin and nystatin. The groups were comparable in factors that might influence the course of leukemia and susceptibility to infection. Environmental maneuvers were effective in reducing the potential inoculum of ambient microorganisms. Patients in group 1 had half as many severe infections as those in groups 2 and 3. Whereas approximately 25% of the patients in groups 2 and 3 died of infection while on study, none in group 1 died for that reason. Despite fewer infections in group 1, no intergroup differences were found in remission rate or duration. The results indicate that the use of oral nonabsorbable antibiotics alone did not reduce the frequency of severe infection or the rate of deaths in which infection was the proximate cause.
KW  - Gentamicin--combination, vancomycin, nystatin-;
KW  - Vancomycin--combination, gentamicin, nystatin-;
KW  - Nystatin--combination, gentamicin, vancomycin-;
KW  - Antibiotics--combined therapy--infections, reduction, lack of effect, in leukemic patients;
KW  - Combined therapy--antibiotics--infections, reduction, lack of effect, in leukemic patients;
KW  - Infections--prophylaxis--antibiotics, combined therapy, lack of effect, in leukemic patients;
KW  - Toxicity, environmental--infections--hospitals, prophylaxis, combined antibiotic therapy lacks effect, in leukemic patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - POST, ROBERT M.
AU  - GORDON, EDNA K.
AU  - GOODWIN, FREDERICK K.
AU  - BUNNEY JR., WILLIAM E.
T1  - Central Norepinephrine Metabolism in Affective Illness: MHPG in the Cerebrospinal Fluid.
JO  - Science
JF  - Science
Y1  - 1973/03/09/
VL  - 179
IS  - 4077
M3  - Article
SP  - 1002
EP  - 1003
SN  - 00368075
AB  - Concentrations of the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl glycol in cerebrospinal fluid were measured by a gas chromatographic method in 34 patients with affective illness and in 44 controls. Concentrations of this metabolite in spinal fluid were significantly lower in depressed patients than in controls or manic patients. These low values may occur secondary to depressive phenomena such as reduced psychomotor activity, or they may reflect a primary change in norepinephrine metabolism in depressive illness. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158403; POST, ROBERT M. 1; GORDON, EDNA K. 1; GOODWIN, FREDERICK K. 1; BUNNEY JR., WILLIAM E. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/ 9/1973, Vol. 179 Issue 4077, p1002; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROSENTHAL, DAVID
T1  - Etiology of Psychosis.
JO  - Science
JF  - Science
Y1  - 1973/03/16/
VL  - 179
IS  - 4078
M3  - Article
SP  - 1117
EP  - 1118
SN  - 00368075
N1  - Accession Number: 85158433; ROSENTHAL, DAVID 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 3/16/1973, Vol. 179 Issue 4078, p1117; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DELONG, M. R.
T1  - Putamen: Activity of Single Units during Slow and Rapid Arm Movements.
JO  - Science
JF  - Science
Y1  - 1973/03/23/
VL  - 179
IS  - 4079
M3  - Article
SP  - 1240
EP  - 1242
SN  - 00368075
AB  - The activity of putamen neurons was studied in a monkey during the performance of both slow and rapid arm movements. More than half of all movement-related units discharged preferentially in relation to slow movements and less than 10 percent in relation to rapid movements. These findings indicate that at least a portion of the basal ganglia (the putamen) is primarily involved in the control of slow movements and are consistent with the hypothesis of Kornhuber that the primary motor function of the basal ganglia is to generate slow ("ramp") rather than rapid ("ballistic") movements. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158487; DELONG, M. R. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/23/1973, Vol. 179 Issue 4079, p1240; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GILLESPIE, D.
AU  - TAKEMOTO, K.
AU  - ROBERT, M.
AU  - GALLO, R. C.
T1  - Polyadenylic Acid in Visna Virus RNA.
JO  - Science
JF  - Science
Y1  - 1973/03/30/
VL  - 179
IS  - 4080
M3  - Article
SP  - 1328
EP  - 1330
SN  - 00368075
AB  - Visna virus 70S RNA colllains long stretches of polyadenylic acid [poly(A)]. The homogeneity in length of poly( 4) regions is observed in 70S RNA from visna virus and all RNA tumor viruses tested, and not with other types of RNA. By this criterion visna virus resembles RNA tumor viruses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117058; GILLESPIE, D. 1; TAKEMOTO, K. 2; ROBERT, M. 3; GALLO, R. C. 3; Affiliations: 1: Litton Bionetics, Inc., Bethesda, Maryland 20014; 2: Laboratory of Viral Disease, National Institute of Allergy and Infectious Diseases, Bethesda 20014; 3: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda 20014; Issue Info: 3/30/1973, Vol. 179 Issue 4080, p1328; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CARPENTER, DAVID O.
T1  - Electrogenic Sodium Pump and High Specific Resistance in Nerve Cell Bodies of the Squid.
JO  - Science
JF  - Science
Y1  - 1973/03/30/
VL  - 179
IS  - 4080
M3  - Article
SP  - 1336
EP  - 1338
SN  - 00368075
AB  - An electrogenic sodium pump contributes to the membrane potential in squid nerve cell bodies, imparting a temperature dependence to the resting potential that is abolished by strophanthidin. The existence of a potential produced by the pump in the soma but not the axon is correlated with a higher membrane resistance in the soma. Thus, membranes from different parts of a neuron may have functionally significant differences in resistance. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117063; CARPENTER, DAVID O. 1,2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 3/30/1973, Vol. 179 Issue 4080, p1336; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Blum, R. H.;
AU  - Carter, S. K.;
AU  - Agre, K.;
T1  - Clinical review of bleomycin\M/new antineoplastic agent
CT  - Clinical review of bleomycin\M/new antineoplastic agent
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1973/04/01/
VL  - 31
IS  - Apr
SP  - 903
EP  - 914
AD  - Cancer Therapy Evaluation Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-2955; Language: English; Chemical Name: Bleomycin--11056-06-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents bleomycin; References: 26; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - A review of data from clinical trials of bleomycin in 1,174 patients, summarized by cell type, is presented. The most commonly used dose schedule was 15 mg./sq. m. I.V. twice weekly. Significant response rates were achieved in patients with squamous cell carcinoma of various anatomical sites, lymphomas, and testicular carcinoma. Most responses were of 1 to 2 months duration. Drug toxicities included significant skin and pulmonary complications and some degree of drug induced pyrexia and nausea with vomiting. Rate insignificant bone marrow depression was encountered. The limitations of a retrospective clinical review of this type using uncontrolled pooled data from various patient populations were discussed. In conclusion, bleomycin appeared to be useful in the treatment of patients with specific tumors refractory to standard treatment and/or whose bone marrow status precluded the use of conventional chemotherapy.
KW  - Bleomycin--cancer-;
KW  - Antineoplastic agents--bleomycin--cancer, therapy, statistics, review;
KW  - Statistics--bleomycin--cancer, therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Sherwood, G.
AU  - Blaese, R. M.
T1  - PHYTOHAEMAGGLUTININ-INDUCED CYTOTOXIC EFFECTOR LYMPHOCYTE FUNCTION IN PATIENTS WITH THE WISKOTT-ALDRICH SYNDROME (WAS).
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1973/04//
VL  - 13
IS  - 4
M3  - Article
SP  - 515
EP  - 520
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Patients with the Wiskott-Aldrich syndrome have immunodeficiency characterized by defective antibody production and clinical anergy. In vitro lymphocyte proliferative responses to non-specific mitogens in these patients, however, are normal. To determine if their anergy might be the result of failure to produce cytotoxic effector lymphocytes, peripheral blood leucocytes were cultured with 51Cr-labelled chicken erythrocyte targets in the presence of PHA. Lymphocytes from patients with the Wiskott-Aldrich syndrome had normal PHA induced cytotoxicity responses and this result is discussed in relation to a postulated defect in the afferent limb of the immune response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNODEFICIENCY
KW  - SYNDROMES
KW  - LEUCOCYTES
KW  - MITOGENS
KW  - LYMPHOCYTES
KW  - BLOOD cells
N1  - Accession Number: 14544933; Sherwood, G. 1 Blaese, R. M. 1; Affiliation:  1: National Cancer Institute and Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Apr73, Vol. 13 Issue 4, p515; Subject Term: IMMUNODEFICIENCY; Subject Term: SYNDROMES; Subject Term: LEUCOCYTES; Subject Term: MITOGENS; Subject Term: LYMPHOCYTES; Subject Term: BLOOD cells; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eaertzen, Charles A.
AU  - Hooks Jr., Nali T.
T1  - DICTIONARY OF DRUG ASSOCIATIONS TO HEROIN, BENZEDRINE, ALCOHOL, BARBITURATES AND MARIJUANA.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1973/04//
VL  - 29
IS  - 2
M3  - Article
SP  - 115
EP  - 164
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses a dictionary of drug associations to heroin, benzedrine, alcohol, barbiturates and marijuana. A 3500 word dictionary of drug associations was constructed by having 20 or more opiate addicts associate words to heroin, benzedrine, alcohol, goof balls, and reefers. Broad sampling of words was attempted through selection of the 1000 most frequently used English words. The dictionary may be useful as a resource for the selection of words for studies of conditioning, verbal learning, perception, or individual differences, cues for possible educational objectives on drugs, evaluation of the drug relatedness of words chosen for experiments by some non-dictionary criteria, and as a standard to compare the associational values of other drug users or addictive types with different presumed habit strengths.
KW  - ENCYCLOPEDIAS & dictionaries
KW  - DRUG abuse
KW  - DRUGS of abuse
KW  - MARIJUANA
KW  - ALCOHOL
KW  - VOCABULARY
N1  - Accession Number: 15844507; Eaertzen, Charles A. 1 Hooks Jr., Nali T. 1; Affiliation:  1: National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky.; Source Info: Apr1973, Vol. 29 Issue 2, p115; Subject Term: ENCYCLOPEDIAS & dictionaries; Subject Term: DRUG abuse; Subject Term: DRUGS of abuse; Subject Term: MARIJUANA; Subject Term: ALCOHOL; Subject Term: VOCABULARY; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; Number of Pages: 50p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Taussig, Lynn M.
AU  - Braunstein, Glenn D.
T1  - EFFECTS OF VASOPRESSIN ON SWEAT RATE AND COMPOSITION IN PATIENTS WITH DIABETES INSIPIDUS AND NORMAL CONTROLS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1973/04//
VL  - 60
IS  - 4
M3  - Article
SP  - 197
EP  - 202
SN  - 0022202X
AB  - Baseline sweat rate and concentrations of sodium, chloride, and potassium, and the effect of exogenous vasopressin on these parameters were determined in 13 patients with acquired diabetes insipidus (ADI), four patients with nephrogenic diabetes insipidus (NDI), three subjects with cystic fibrosis, and age- and sex-matched controls. The four patients with NDI did not differ from the controls with respect to baseline sweat rate, but baseline sodium, chloride, and potassium concentrations were significantly elevated. In addition, parenteral vasopressin caused a significant decrease in sweat rate (p < .01) while the electrolyte concentrations remained unchanged. This indicates that vasopressin may also have an effect on electrolyte reabsorption in NDI patients. Alternatively, the amount of sweat precursor fluid may have been reduced. The patients with ADI did not differ from the controls with respect to baseline data, and parenteral vasopressin had no effect on their sweat rate and composition. Likewise, vasopressin had no effect in controls or patients with cystic fibrosis. We conclude that, except in patients with NDI, vasopressin does not play a significant role in the regulation of human eccrine sweating. Sweat gland physiology appears to be different in patients with NDI and in them vasopressin may have a significant effect on sweat. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VASOPRESSIN
KW  - PERSPIRATION
KW  - SWEAT glands
KW  - SODIUM
KW  - CHLORIDES
KW  - DIABETES
N1  - Accession Number: 12724468; Taussig, Lynn M. 1 Braunstein, Glenn D. 2; Affiliation:  1: Pediatric Metabolism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institute of Health, Bethesda, Maryland, 20014.  2: Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014.; Source Info: Apr73, Vol. 60 Issue 4, p197; Subject Term: VASOPRESSIN; Subject Term: PERSPIRATION; Subject Term: SWEAT glands; Subject Term: SODIUM; Subject Term: CHLORIDES; Subject Term: DIABETES; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12724468
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cradock, J. C.;
AU  - Davignon, J. P.;
AU  - Litterst, C. L.;
AU  - Guarino, A. M.;
T1  - Intravenous formulation of delta-9-tetrahydrocannabinol using a nonionic surfactant
CT  - Intravenous formulation of delta-9-tetrahydrocannabinol using a nonionic surfactant
JO  - Journal of Pharmacy and Pharmacology (England)
JF  - Journal of Pharmacy and Pharmacology (England)
Y1  - 1973/04/01/
VL  - 25
IS  - Apr
SP  - 345
SN  - 03731022
AD  - Drug Development Branch and Laboratory of Toxicology, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-0086; Language: English; Publication Type: Letters; Journal Coden: JPPMAB; Section Heading: Pharmaceutics
KW  - Tetrahydrocannabinol--injections-;
KW  - Formulations--tetrahydrocannabinol--injections, I.V., using nonionic surfactant;
KW  - Injections--tetrahydrocannabinol--intravenous, formulations, using nonionic surfactant;
KW  - Surface active agents--nonionic--in I.V. formulation of tetrahydrocannabinol;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bennett, J. E.;
T1  - Treatment of systemic mycoses
CT  - Treatment of systemic mycoses
JO  - Ration. Drug Ther.
JF  - Ration. Drug Ther.
Y1  - 1973/04/01/
VL  - 7
IS  - Apr
SP  - 1
EP  - 4
AD  - Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
N1  - Accession Number: 11-1721; Language: English; Trade Name: Ancobon; Generic Name: Flucytosine; Chemical Name: Amphotericin B--1397-89-3 Nystatin--1400-61-9 Flucytosine--2022-85-7; Therapeutic Class: (8:12.04); AHFS Class: Fungicides flucytosine (8:12.04); AHFS Class: Fungicides hydroxystilbamidine; Journal Coden: RDGTAP; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: James W. Cooper, Jr.
N2  - A discussion of the use, pharmacology, toxicity, physical properties and dosing of the polyene antibiotics (amphotericin B and nystatin), flucytosine (Ancobon), hydroxystilbamidine and iodide in systemic and cutaneous mycoses is presented.
KW  - Amphotericin B--mycoses-;
KW  - Nystatin--mycoses-;
KW  - Flucytosine--mycoses-;
KW  - Hydroxystilbamidine--mycoses-;
KW  - Iodides--mycoses--systemic, therapy, discussion;
KW  - Toxicity--drugs--mycoses, systemic, therapy, discussion;
KW  - Fungicides--flucytosine--mycoses, systemic, therapy, discussion;
KW  - Fungicides--hydroxystilbamidine--mycoses, systemic, therapy, discussion;
KW  - Fungicides--iodide--mycoses, systemic, therapy, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-41559-008
AN  - 2013-41559-008
AU  - Nelson, Scott H.
AU  - Torrey, E. Fuller
T1  - The religious functions of psychiatry.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/04//
VL  - 43
IS  - 3
SP  - 362
EP  - 367
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Nelson, Scott H., 3125 North Eighth Street, Arlington, VA, US, 22201
N1  - Accession Number: 2013-41559-008. PMID: 4711078 Partial author list: First Author & Affiliation: Nelson, Scott H.; Health Services and Mental Health Administration, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Psychiatry; Religion; Religious Practices; Social Values. Minor Descriptor: Mental Health Personnel. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1973. 
AB  - Three functions traditionally recognized as being in the domain of religion are increasingly being assumed by mental health practitioners: 1) explanation of the unknown; 2) ritual and social functions; and 3) the definition of values. The authors recommend that religious and mental health practitioners define their functions and roles more clearly, so that they may interact more constructively (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - religious functions
KW  - psychiatry
KW  - mental health practitioners
KW  - ritual functions
KW  - religious values
KW  - 1973
KW  - Psychiatry
KW  - Religion
KW  - Religious Practices
KW  - Social Values
KW  - Mental Health Personnel
KW  - 1973
DO  - 10.1111/j.1939-0025.1973.tb00806.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - GERWIN, BRENDA I.
AU  - EBERT, PAUL S.
AU  - CHOPRA, HARISH C.
AU  - SMITH, SUSAN G.
AU  - KVEDAR, JOHN P.
AU  - ALBERT, SAM
AU  - BRENNAN, MICHAEL J.
T1  - DNA Polymerase Activities of Human Milk.
JO  - Science
JF  - Science
Y1  - 1973/04/13/
VL  - 180
IS  - 4082
M3  - Article
SP  - 198
EP  - 201
SN  - 00368075
AB  - DNA polymerases have been partially purified from human milk. A DNA polymerase detected by phosphocellulose chromatography is similar to the enzymes of RNA tumor viruses in that a hybrid of polyriboadenylate and oligodeoxythymidylate is a better template than is DNA. However, this polymerase differed from that of the RNA tumor viruses in its chromatographic behavior. Three different methods of detecting "reverse transcriptase" activity failed to correlate with the donor's family history of cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85178607; GERWIN, BRENDA I. 1; EBERT, PAUL S. 1; CHOPRA, HARISH C. 1; SMITH, SUSAN G. 1; KVEDAR, JOHN P. 1; ALBERT, SAM 2; BRENNAN, MICHAEL J. 2; Affiliations: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; 2: Michigan Cancer Foundation, Detroit 48201; Issue Info: 4/13/1973, Vol. 180 Issue 4082, p198; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - UZUNOV, PETKO
AU  - SHEIN, HARVEY M.
AU  - WEISS, BENJAMIN
T1  - Cyclic AMP Phosphodiesterase in Cloned Astrocytoma Cells: Norepinephrine Induces a Specific Enzyme Form.
JO  - Science
JF  - Science
Y1  - 1973/04/20/
VL  - 180
IS  - 4083
M3  - Article
SP  - 304
EP  - 306
SN  - 00368075
AB  - The soluble supernatant fraction of homogenates of cloned rat astrocytoma cells (line C-2A) was subjected to polyacrylamide gel electrophoresis. Two peaks of adenosine 3',5'-monophosphate phosphodiesterase activity were found, corresponding to peaks I and IV of a similarly prepared homogenate of rat brain. Incubating cells with norepinephrine (0.3 mullimolar) caused about a threefold increase in the activity of peak IV but no change in peak I. This increase was completely inhibited by prior inclubation with propranolol (0.1 millimnolar), a beta-adrenergic blocking agent, or with cyclohexamnine (40 micromolar). a protein synthesis inhibitor. Induction of a specific phosphodiesterase form by norepinephrine sitggests another feedback control mechanism whereby an organism can prevent the effects of excessive sympathetic activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136011; UZUNOV, PETKO 1; SHEIN, HARVEY M. 2; WEISS, BENJAMIN 3,4; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: McLean Hospital, Belmont, Maassachusetts 02178; 3: Laboratory of Preclinical Pharmacology, National Institute of Mental Health; 4: Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129; Issue Info: 4/20/1973, Vol. 180 Issue 4083, p304; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TYERYAR JR., FRANKLIN J.
AU  - WEISS, EMILIO
AU  - MILLAR, DAVID B.
AU  - BOZEMAN, F. MARILYN
AU  - ORMSBEE, RICHARD A.
T1  - DNA Base Composition of Rickettsiae.
JO  - Science
JF  - Science
Y1  - 1973/04/27/
VL  - 180
IS  - 4084
M3  - Article
SP  - 415
EP  - 417
SN  - 00368075
AB  - There is a small but distinct difference in DNA base composition between the typhus and spotted fever groups of rickettsiae. The molar percentages of guanine plus cytosine for Rickettsia prowazeki, R. typhi, and R. canada are approximately 30, for R. rickettsi, R. conori, and R. akari they are about 32.5. The percentage for trench fever rickettsia, Rochalimaea quintana, is 38.6. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158527; TYERYAR JR., FRANKLIN J. 1; WEISS, EMILIO 1; MILLAR, DAVID B. 1; BOZEMAN, F. MARILYN 2; ORMSBEE, RICHARD A. 3; Affiliations: 1: Naval Medical Research Institute, Bethesda, Maryland, 20014; 2: Walter Reed Army Institute of Research, Washington, D.C., 20012; 3: National Institute of Allergy and Infectious Diseases, Hamilton, Montana, 59840; Issue Info: 4/27/1973, Vol. 180 Issue 4084, p415; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TING, KAI-LI H.
AU  - LEE, R. C. T.
AU  - MILNE, G. W. A.
AU  - SHAPIRO, M.
AU  - GUARINO, A. M.
T1  - Applications of Artificial Intelligence: Relationships between Mass Spectra and Pharmacological Activity of Drugs.
JO  - Science
JF  - Science
Y1  - 1973/04/27/
VL  - 180
IS  - 4084
M3  - Article
SP  - 417
EP  - 420
SN  - 00368075
AB  - The possibility that the mass spectrum and pharmacological activity of a compound may be directly related has been explored with the help of various computer-based pattern-recognition techniques. The relationship appears to hold at least for tranquilizers and sedatives, and compounds with one or the other of these two pharmacological activities can thus be classified from their mass spectra with a high degree of accuracy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158528; TING, KAI-LI H. 1; LEE, R. C. T. 1; MILNE, G. W. A. 1; SHAPIRO, M. 1; GUARINO, A. M. 1; Affiliations: 1: Division of Computer Research and Technology, National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014; Issue Info: 4/27/1973, Vol. 180 Issue 4084, p417; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Greenhill, L. L.;
AU  - Rieder, R. O.;
AU  - Wender, P. H.;
AU  - Buchsbaum, M.;
AU  - Zahn, T. P.;
T1  - Lithium carbonate in the treatment of hyperactive children
CT  - Lithium carbonate in the treatment of hyperactive children
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1973/05/01/
VL  - 28
IS  - May
SP  - 636
EP  - 640
AD  - (Reprints: Rousso Building, 1165 Morris Park Avenue, Bronx, New York 10461
AD  - National Institute of Mental Health, Laboratory of Psychology, Bethesda, Maryland
N1  - Accession Number: 11-1060; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 15; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Lithium carbonate, in 150 mg. doses that reached a blood level of 0.8 to 1.2 meq./l. was tested in 9 severely hyperactive children who were unresponsive to stimulant medication. In the 3-month modified double-blind trial, lithium carbonate was alternated with dextroamphetamine or placebo. Six children showed no improvement or a worsening of symptoms when given lithium carbonate and one dropped out of the study. Two children who improved transiently had been observed to have effective symptoms and differed on psychophysiological measures from the rest of the group.
KW  - Lithium carbonate--hyperkinesis-;
KW  - Psychotherapeutic agents--lithium carbonate--hyperkinesis, lack of effects, in children;
KW  - Blood levels--lithium carbonate--hyperkinesis, lack of effect, in children;
KW  - Metabolism--lithium carbonate--blood levels, hyperkinesis, lack of effect, in children;
KW  - Hyperkinesis--lithium carbonate--lack, effects, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hochstein, H. D.;
AU  - Elin, R. J.;
AU  - Cooper, J. F.;
AU  - Seligmann, E. B., Jr.;
AU  - Wolff, S. M.;
T1  - Further developments of limulus amebocyte lysate test
CT  - Further developments of limulus amebocyte lysate test
JO  - Bull. Parenteral Drug Assoc.
JF  - Bull. Parenteral Drug Assoc.
Y1  - 1973/05/01/
VL  - 27
IS  - May-Jun
SP  - 139
EP  - 148
AD  - Bureau of Biologics, FDA, National Institute of Allergy and Infectious Diseases, NIH, Bureau of Radiological Health, FDA, Bethesda, Maryland
N1  - Accession Number: 11-0683; Language: English; References: 10; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2  - A discussion of methods used for lysing the blood cells of the horseshoe crab, Limulus polyphemus, and the quality of lysate obtained for use in pyrogen testing, is presented. Amebocyte lysates were prepared from approximately one thousand sexually immature and mature horseshoe crabs, \IT/Limulus polyphemus\OK/. Cell suspending media are discussed along with osmotic pressure, vortex mixing, glass tissue homogenizer, lyophilization, and sonification as methods for amebocyte lysis.
KW  - Tests--pyrogens--Limulus amebocyte lysate, methods of preparation;
KW  - Pyrogens--tests--Limulus amebocyte lysate, methods of preparation;
KW  - Lyophilization--lysate--Limulus amebocyte, preparation, for pyrogen testing, in vitro;
KW  - Limulus polyphemus--amebocyte lysate--preparation, methods, for pyrogen testing, in vitro;
KW  - Methodology--Limulus polyphemus--amebocyte lysate, preparation, for in vitro pyrogen testing;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - Walker, M. D.;
AU  - Canellos, G. P.;
AU  - Schein, P. S.;
AU  - Chabner, B. A.;
AU  - \ET/;
T1  - Initial clinical trials with methyl-CCNU 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (M\LC/e\UC/CCNU)
CT  - Initial clinical trials with methyl-CCNU 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (M\LC/e\UC/CCNU)
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1973/05/01/
VL  - 31
IS  - May
SP  - 1164
EP  - 1169
AD  - Building 10, Room 12N226, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-2419; Language: English; Trade Name: MeCCNU; Generic Name: Lomustine; Chemical Name: Lomustine--13010-47-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents lomustine; References: 11; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - An evaluation of methyl CCNU (methyl lomustine; I) in 50 patients with various carcinomas is presented. Preliminary clinical trials indicate that I is well tolerated and biologically active when given orally. Ten of the 50 patients in the study had objective therapeutic responses to I. Responses were seen in patients with melanoma, primary brain tumors, Hodgkin's disease, lymphosarcoma, and reticulum cell sarcoma. The primary toxicity of this agent is delayed myelosuppression, which appears 3 to 5 weeks after a single oral dose and is usually manifest as thrombocytopenia. No significant renal or hepatic side effects have been observed. Some evidence for cumulative marrow toxicity was noted in 42% of the patients receiving multiple doses. In previously treated patients there is usually consistent, but tolerable, marrow suppression at a dose of 200 mg./sq.m. although extent of prior therapy will necessitate individualizing the dose in many instances.
KW  - Lomustine--methyl-;
KW  - Antineoplastic agents--lomustine--methyl, carcinoma therapy, and toxicity, in patients;
KW  - Toxicity--lomustine--methyl, in cancer patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Boylston, A.W.
T1  - Theta Antigen and Immunoglobulin on a Tissue-cultured Mouse Lymphoma.
JO  - Immunology
JF  - Immunology
Y1  - 1973/05//
VL  - 24
IS  - 5
M3  - Article
SP  - 851
EP  - 857
PB  - Wiley-Blackwell
SN  - 00192805
AB  - E1-4, a tissue culture established murine lymphoma, is shown to carry the θ-antigen and to have immunoglobulin in its membrane. Both are present in quantities similar to those found on normal C57 B1/6N thymocytes. This cell line may prove a useful model for the study of T cell membranes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - LYMPHOMAS
KW  - IMMUNOGLOBULINS
KW  - T cells
KW  - CELL lines
KW  - BIOLOGICAL membranes
N1  - Accession Number: 13384989; Boylston, A.W. 1; Affiliation:  1: Hematology Laboratory, Department of Clinical Pathology, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: May73, Vol. 24 Issue 5, p851; Subject Term: ANTIGENS; Subject Term: LYMPHOMAS; Subject Term: IMMUNOGLOBULINS; Subject Term: T cells; Subject Term: CELL lines; Subject Term: BIOLOGICAL membranes; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kirkpatrick, C. H.;
AU  - Meek, J. C.;
AU  - Rich, R. R.;
T1  - Mechanism of allergy to components of commercial bovine thyrotropin
CT  - Mechanism of allergy to components of commercial bovine thyrotropin
JO  - J. Allergy Clin. Immunol.
JF  - J. Allergy Clin. Immunol.
Y1  - 1973/05/01/
VL  - 51
IS  - May
SP  - 296
EP  - 302
AD  - Building 10, Room 11B-13 National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-4467; Language: English; Trade Name: TSH; Generic Name: Thyrotropin; Chemical Name: Thyrotropin--9002-71-5 Thyroid--8028-36-2; References: 20; Journal Coden: JACIBY; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Ronald E. Nagata, Jr.
N2  - A 24-year-old woman with hypothyroidism and chronic mucocutaneous candidiasis developed a systemic immediate-type allergic reaction to bovine thyrotropin (TSH) injection. Precipitating antibodies against bovine serum albumin and gamma globulin were present in the patient's serum. Skin testing with bovine TSH and BSA provoked wheal-and-flare reactions.
KW  - Thyrotropin--adverse reactions-;
KW  - Thyroid--thyrotropin-;
KW  - Drugs, adverse reactions--thyrotropin--allergies, systemic, in hypothyroid patient;
KW  - Sensitivity--thyrotropin--allergies, systemic, in hypothyroid patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hurst, K. S.;
AU  - Byar, D. P.;
T1  - Analysis of the effects of changes from the assigned treatment in a clinical trial of treatment for prostatic cancer
CT  - Analysis of the effects of changes from the assigned treatment in a clinical trial of treatment for prostatic cancer
JO  - J. Chronic Dis.
JF  - J. Chronic Dis.
Y1  - 1973/05/01/
VL  - 26
IS  - May
SP  - 311
EP  - 324
AD  - VA Cooperative Urological Research Group, Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, N1H, Landow Building Room C-519, Bethesda, Maryland 20014
N1  - Accession Number: 11-1670; Language: English; References: 11; Journal Coden: JOCDAE; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The clinical course of patients originally part of a large scale randomized prospective clinical trial of treatment for cancer of the prostate who were later taken off study and given additional therapy is described. The following observations were made: Patients whose initial treatment was placebo were more likely to be taken off study, were taken off study when they were in comparatively better health than patients on the other treatments, and survived longer after going off study. Patients whose original treatment was placebo were more likely to benefit from secondary treatment. There was no evidence in these data that the treatment with estrogen in the late stages of cancer of the prostate was associated with increased risk of death due to cardiovascular causes. A decrease in the acid phosphatase could occur late in the course of the disease if therapy was changed even if the initial therapy included estrogen or orchiectomy or both. The results of this analysis are consistent with the philosophy that hormonal treatment or orchiectomy for cancer of the prostate should be witheld until it is required for relief of symptoms.
KW  - Estrogens--carcinomas--prostatic, rational therapy, in patients;
KW  - Antineoplastic agents--estrogens--carcinomas, prostatic, rational therapy, in patients;
KW  - Rational therapy--estrogens--carcinomas, prostatic, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2005-10589-012
AN  - 2005-10589-012
AU  - Torres, Lorraine B.
T1  - The Participants in Social Science Research.
JF  - Professional Psychology
JO  - Professional Psychology
JA  - Prof Psychol
Y1  - 1973/05//
VL  - 4
IS  - 2
SP  - 211
EP  - 216
CY  - US
PB  - American Psychological Association
SN  - 0033-0175
N1  - Accession Number: 2005-10589-012. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Torres, Lorraine B.; Social Sciences Section, Behavioral Sciences Research Branch, National Institute of Mental Health, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Social Sciences. Minor Descriptor: Government Agencies. Classification: Research Methods & Experimental Design (2260); Professional Psychological & Health Personnel Issues (3400). Page Count: 6. Issue Publication Date: May, 1973. Copyright Statement: American Psychological Association. 1973. 
AB  - Comments about the relationships between those who 'produce' and those who 'use' research. The author discusses the National Institute for Mental Health's programs and defines the relationships of the producers and the users of research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social science research
KW  - producers & users of research
KW  - National Institute for Mental Health
KW  - programs
KW  - 1973
KW  - Experimentation
KW  - Social Sciences
KW  - Government Agencies
KW  - 1973
DO  - 10.1037/h0020901
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - HENDERSON JR, U. V.
AU  - STEIN, BERNARD R.
AU  - STETTEN JR, DEWITT
T1  - Research Planning.
JO  - Science
JF  - Science
Y1  - 1973/05/04/
VL  - 180
IS  - 4085
M3  - Article
SP  - 448
EP  - 448
SN  - 00368075
N1  - Accession Number: 85117116; HENDERSON JR, U. V.; STEIN, BERNARD R.; STETTEN JR, DEWITT 1; Affiliations: 1: National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 5/ 4/1973, Vol. 180 Issue 4085, p448; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T.;
AU  - Schein, P. S.;
T1  - Use of drugs in combination for the treatment of cancer
CT  - Use of drugs in combination for the treatment of cancer
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1973/05/10/
VL  - 288
IS  - May 10
SP  - 998
EP  - 006
SN  - 00284793
AD  - Building 10, 12N226, National Cancer Institute, Bethesda, Maryland 10014
N1  - Accession Number: 10-4278; Language: English; References: 75; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2  - A review is presented on the use of drugs in combination for the treatment of cancer; and clinical studies employing drug combinations are discussed. It was stated that combination therapy has been employed in the treatment of cancer because satisfactory results are usually not obtained using single treatment.
KW  - Combined therapy--antineoplastic agents--effects, review, in patients;
KW  - Antineoplastic agents--combined therapy--effects, review, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - ROWE, WALLACE P.
AU  - SATO, HIDETOSHI
T1  - Genetic Mapping of the Fv-1 Locus of the Mouse.
JO  - Science
JF  - Science
Y1  - 1973/05/11/
VL  - 180
IS  - 4086
M3  - Article
SP  - 640
EP  - 641
SN  - 00368075
AB  - The Fv-l locus of the mouse, a major determinant of the biology of murine leukemia virus, is very closely linked to Gpd-I on chromosome 4 (linkage group VIII). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436881; ROWE, WALLACE P. 1; SATO, HIDETOSHI 2; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Division of Immunology, Sloan Kettering Institute for Cancer Research, New York 10021; Issue Info: 5/11/1973, Vol. 180 Issue 4086, p640; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARON, SAMUEL
AU  - FINTER, NORMAN B.
AU  - GALASSO, GEORGE J.
AU  - GLASGOW, LOWELL A.
AU  - LEVY, HILTON B.
AU  - YOUNGER, JULIUS S.
T1  - Interferon.
JO  - Science
JF  - Science
Y1  - 1973/05/18/
VL  - 180
IS  - 4087
M3  - Article
SP  - 779
EP  - 784
SN  - 00368075
N1  - Accession Number: 85117196; BARON, SAMUEL 1; FINTER, NORMAN B. 1; GALASSO, GEORGE J. 1; GLASGOW, LOWELL A. 1; LEVY, HILTON B. 1; YOUNGER, JULIUS S. 1; Affiliations: 1: Antiviral Substances Program, Infectious Disease Branch, Collaborative Research Program, National Institute of Allergy and Infectious Diseases, Building 31, Bethesda, Maryland 20014; Issue Info: 5/18/1973, Vol. 180 Issue 4087, p779; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - STEPHENSON, JOHN R.
AU  - AARONSON, STUART A.
T1  - Segregation of Loci for C-Type Virus Induction in Strains of Mice with High and Low Incidence of Leukemia.
JO  - Science
JF  - Science
Y1  - 1973/05/25/
VL  - 180
IS  - 4088
M3  - Article
SP  - 865
EP  - 866
SN  - 00368075
AB  - Multiple genetic loci for induction of murine leukemia viruses are demonstrated in cells of the high leukemic incidence C58 mouse strain. The biologic properties of viruses at C58 inducibility loci are clearly distinguishable from those of viruses activated from mouse cells containing a locus for virus induction of the low leukemia incidence BALB/c strain. These findings are consistent with the hypothesis that the genes for virus induction in normal mouse embryo cells represent viral structural information. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158560; STEPHENSON, JOHN R. 1; AARONSON, STUART A. 1; Affiliations: 1: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 5/25/1973, Vol. 180 Issue 4088, p865; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeFronzo, R. A.;
AU  - Braine, H.;
AU  - Colvin, O. M.;
AU  - Davis, P. J.;
T1  - Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation
CT  - Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1973/06/01/
VL  - 78
IS  - Jun
SP  - 861
EP  - 869
SN  - 00034819
AD  - Metabolism Section, Clinical Physiology Branch, Gerontology Research Center, National Institute of Child Health and Human Development, NIH, Bethesda; and Department of Medicine and Division of Oncology, Johns Hopkins University and Baltimore City Hospitals, Baltimore, Maryland
N1  - Accession Number: 10-4675; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 20; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Judith A. Kepler
N2  - Cyclophosphamide I. V. therapy in doses greater than 50 mg./kg. has resulted in frank impairment of water excretion in 17 of 19 normally hydrated patients with cancer. Clinically, these patients developed hyponatremia,weight gain, and inappropriately concentrated urine during cyclophosphamide infusion. These findings relate to the in vivo conversion of cyclophosphamide to its active alkylating metabolites. The syndrome is reversible after withdrawal of the drug.
KW  - Cyclophosphamide--toxicity-;
KW  - Toxicity--cyclophosphamide--water intoxication, in patients;
KW  - Antineoplastic agents--cyclophosphamide--water intoxication, in patients;
KW  - Dosage--cyclophosphamide--water intoxication, in patients;
KW  - Metabolism--cyclophosphamide--and water intoxication due to metabolites, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Martin, W. R.;
AU  - Jasinski, D. R.;
AU  - Mansky, P. A.;
T1  - Naltrexone, an antagonist for the treatment of heroin dependence
CT  - Naltrexone, an antagonist for the treatment of heroin dependence
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1973/06/01/
VL  - 28
IS  - Jun
SP  - 784
EP  - 791
AD  - National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky 40507
N1  - Accession Number: 11-0747; Language: English; Trade Name: EN-1639A--Narcan; Generic Name: Naltrexone; Naloxone; Chemical Name: Naltrexone--16590-41-3; References: 18; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Ronald E. Nagata, Jr.
N2  - A series of studies to determine the pharmacologic potency of naltrexone (EN-1639A), a narcotic antagonist, were performed on 13 patients. Naltrexone antagonism is 17 times more potent than nalorphine; the drug is longer acting than naloxone (Narcan), but shorter than cyclazocine. A comparable degree of heroin or morphine blockade was achieved by daily doses of 50 mg. of naltrexone and 4 mg. of cyclazocine. As an orally effective agent, naltrexone is virtually devoid of agonistic activity, and nalorphine-like dysphoric effects.
KW  - Naltrexone--effects-;
KW  - Narcotic antagonists--naltrexone--effects, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Decker, John L.
AU  - Healey, L. A.
T1  - When to use cytotoxic drugs in rheumatoid arthritis.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1973/06//
VL  - 28
IS  - 6
M3  - Article
SP  - 103
EP  - 106
SN  - 0016867X
N1  - Accession Number: 17729238; Decker, John L. 1; Healey, L. A. 2; Source Information: Jun1973, Vol. 28 Issue 6, p103; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 2165
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Schlesselman, James J.
T1  - Data Transformation in Two-Way Analysis of Variance.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1973/06//
VL  - 68
IS  - 342
M3  - Article
SP  - 369
SN  - 01621459
AB  - A procedure for choosing a power transformation so that data from a replicated two-way classification better satisfy the usual analysis of variance assumptions is described. The statistic proposed in this article is compared with the Box and Cox [7] likelihood procedure by empirical sampling. Its 95 percent confidence intervals performed at their nominal level, which was not true for the likelihood method. Point estimates for both techniques were the same on the average, although those based upon the likelihood statistic were somewhat less variable. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANALYSIS of variance
KW  - ESTIMATION theory
KW  - SAMPLING (Statistics)
KW  - REGRESSION analysis
KW  - MATHEMATICAL statistics
KW  - TRANSFORMATIONS (Mathematics)
KW  - CONFIDENCE intervals
N1  - Accession Number: 4601870; Schlesselman, James J. 1; Affiliations: 1: Senior Staff Fellow, Biometry Branch, National Institute of Child Health and Human Development, Bethesda, Md. 20014.; Issue Info: Jun73, Vol. 68 Issue 342, p369; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Subject Term: TRANSFORMATIONS (Mathematics); Subject Term: CONFIDENCE intervals; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - RAPOPORT, STANLEY I.
AU  - THOMPSON, HARRY K.
T1  - Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits.
JO  - Science
JF  - Science
Y1  - 1973/06//6/ 1/1973
VL  - 180
IS  - 4089
M3  - Article
SP  - 971
EP  - 971
SN  - 00368075
AB  - Hypertonic urea or lactamide solutions osmotically open the bloodbrain barrier in the monkey without producing gross neurological deficits if the blood supply to the brain is not compromised. The brain is perfused via the left lingual artery when the external and common carotid arteries are clamped temporarily. Hypertonic perfusion, which opens the barrier by opening tight junctions between cerebrovascular endothelial cells, can thus be used to study barrier function and brain pharmacology. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85178657; RAPOPORT, STANLEY I. 1; THOMPSON, HARRY K. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/ 1/1973, Vol. 180 Issue 4089, p971; Number of Pages: 1/2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - HAAPALA, DANIEL K.
AU  - FISCHINGER, PETER J.
T1  - Molecular Relatedness of Mammalian RNA Tumor Viruses as Determined by DNA. RNA Hybridization.
JO  - Science
JF  - Science
Y1  - 1973/06//6/ 1/1973
VL  - 180
IS  - 4089
M3  - Article
SP  - 972
EP  - 974
SN  - 00368075
AB  - Each of six mammalian C-type viruses-including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114-can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA - RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85178658; HAAPALA, DANIEL K. 1; FISCHINGER, PETER J. 1; Affiliations: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/ 1/1973, Vol. 180 Issue 4089, p972; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
TY  - GEN
AU  - Fermaglich, J.;
AU  - Chase, T. N.;
T1  - Methyldopa or methyldopahydrazine as levodopa synergists
CT  - Methyldopa or methyldopahydrazine as levodopa synergists
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1973/06/02/
VL  - 1
IS  - Jun 2
SP  - 1261
EP  - 1262
SN  - 00237507
AD  - Georgetown University Medical Center and National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-4554; Language: English; Trade Name: Aldomet--MK-486; Generic Name: Methyldopa; Methyldopahydrazine; Chemical Name: Methyldopa--41372-08-1; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents methyldopa, comparison, methyldopahydrazine (12:08.04); AHFS Class: Antiparkinson agents methyldopahydrazine, comparison, methyldopa; References: 5; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Interactions; Investigational Drugs; Abstract Author: Joan Lentine
N2  - The effects of methyldopa (Aldomet) and MK-486 (methyldopahydrazine) on the potentiation of levodopa were compared in 10 parkinsonian patients. Each patient received MK-486, methyldopa, and placebo, during which time the dose of levodopa was adjusted to maintain an optimum therapeutic response. MK-486 was introduced at a daily dose of 20 mg. and increased weekly to 160 mg. Methyldopa was begun at a dose of 80 mg./day and similarly increased to 1920 mg. Both methyldopa and MK-486 potentiated the ability of levodopa to reduce parkinsonian signs. Potentiation increased directly with increasing doses of methyldopa but tended to level off with MK-486 at daily doses above 80 mg.
KW  - Methyldopa--comparison, methyldopahydrazine-;
KW  - Methyldopahydrazine--comparison, methyldopa-;
KW  - Antiparkinson agents--methyldopa, comparison, methyldopahydrazine--potentiation, levodopa, in parkinsonian patients;
KW  - Antiparkinson agents--methyldopahydrazine, comparison, methyldopa--potentiation, levodopa, in parkinsonian patients;
KW  - Drug interactions--levodopa and methyldopa, comparison, methyldopahydrazine--potentiation, levodopa, in parkinsonian patients;
KW  - Drug interactions--methyldopahydrazine and levodopa--potentiation, levodopa, in parkinsonian patients;
KW  - Drug interactions--methyldopa and levodopa--potentiation, levodopa, in parkinsonian patients;
KW  - Drug interactions--levodopa and methyldopahydrazine, comparison, methyldopa--potentiation, levodopa, in parkinsonian patients;
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ER  - 

TY  - JOUR
AU  - BADER, JOHN P.
T1  - Virus-Induced Transformation without Cell Division.
JO  - Science
JF  - Science
Y1  - 1973/06/08/
VL  - 180
IS  - 4090
M3  - Article
SP  - 1069
EP  - 1071
SN  - 00368075
AB  - Interference with the cell cycle by vinblastine sulfate immediately after cells were infected with Rous sarcoma virus had little effect on the development of two metabolic changes that occur in transformed cells. These results, along with an earlier demonstration of morphological changes developing in infected nondividing cells, demonstrate that the phenotypic development of the malignant state can occur without the intervention of cell divisions after infection by Rous sarcoma virus. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85178699; BADER, JOHN P. 1; Affiliations: 1: Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/ 8/1973, Vol. 180 Issue 4090, p1069; Number of Pages: 3p; Document Type: Article
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ER  - 
TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - Canellos, G. P.;
AU  - Chabner, B. A.;
AU  - Schein, P. S.;
AU  - DeVita, V. T.;
T1  - Maintenance chemotherapy for advanced Hodgkin's disease in remission
CT  - Maintenance chemotherapy for advanced Hodgkin's disease in remission
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1973/06/16/
VL  - 1
IS  - Jun 16
SP  - 1339
EP  - 1343
SN  - 00237507
AD  - National Cancer Institute, Building 10, Room 12N226, Bethesda, Maryland 20014
N1  - Accession Number: 10-4267; Language: English; Trade Name: Nitrogen mustard--Oncovin--BCNU--1,3-bis(2-Chloroethyl)-1-nitrosourea; Generic Name: Mechlorethamine; Vincristine; Carmustine; Carmustine; Chemical Name: Carmustine--154-93-8 Mechlorethamine--51-75-2 Prednisone--53-03-2 Procarbazine--671-16-9 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine; References: 14; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Fifty-seven patients with advanced Hodgkin's disease who entered a complete remission after chemotherapy with mechlorethamine (nitrogen mustard), vincristine (Oncovin), procarbazine, and prednisone (MOPP) were allocated at random to one of 3 regimens\M/no additional therapy, intermittent therapy with MOPP or intermittent therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU: carmustine). 24% of those patients receiving no further therapy have relapsed, as have 25% of those on intermittent MOPP and 13% of those on intermittent BCNU; the differences are not significant. The median duration of initial remissions will be \GT/ 48 months for all the patients, and there is no significant difference between the individual groups. Complications and infections were more frequently seen in the patients receiving maintenance therapy, especially in those on BCNU. Only 1 patient in each of the 3 groups has died of Hodgkin's disease, and survival is not significantly influenced by maintenance therapy. The projected 5-year survival for the entire group of patients is 86%.
KW  - Carmustine--Hodgkin's disease-;
KW  - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW  - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW  - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW  - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW  - Antineoplastic agents--combined therapy--maintenance, Hodgkin's disease, lack, effects, in patients;
KW  - Combined therapy--antineoplastic agents--maintenance, Hodgkin's disease, lack, effects, in patients;
KW  - Antineoplastic agents--carmustine--Hodgkin's disease, maintenance therapy, lack, effects, in patients;
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Woods, A. C.;
AU  - Glaubiger, G. A.;
AU  - Chase, T. N.;
T1  - Sustained-release levodopa
CT  - Sustained-release levodopa
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1973/06/16/
VL  - 1
IS  - Jun 16
SP  - 1391
SN  - 00237507
AD  - Neurology Unit, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-4083; Language: English; Trade Name: Brocadopa Temtabs; Generic Name: Levodopa; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 2; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Biopharmaceutics; Drug Evaluations; Abstract Author: Joan Lentine
N2  - Results of preliminary studies in 3 parkinsonian patients suggested that the irregular response to a sustained-release levodopa preparation (Brocadopa Temtabs) is due to the failure of this preparation to maintain clinically effective plasma dopa concentrations for significantly longer periods than the standard form of levodopa.
KW  - Levodopa--sustained-action-;
KW  - Sustained-action medications--levodopa--effects, irregular, ineffective blood levels, in parkinsonian patients;
KW  - Antiparkinson agents--levodopa--sustained-action, irregular effects, ineffective blood levels, in parkinsonian patients;
KW  - Blood levels--levodopa--sustained-action, ineffective, in parkinsonian patients;
KW  - Metabolism--levodopa--blood levels, ineffective, sustained-action, in parkinsonian patients;
KW  - Formulations--levodopa--sustained-action, effects, irregular, ineffective blood levels, in patients;
KW  - Drugs, availability--levodopa--sustained-action, irregular effects, ineffective blood levels, in parkinsonian patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Broder, L. E.;
AU  - Carter, S. K.;
T1  - Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients
CT  - Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1973/07/01/
VL  - 79
IS  - Jul
SP  - 108
EP  - 118
SN  - 00034819
AD  - Cancer Therapy Evaluation Branch, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland
N1  - Accession Number: 11-4411; Language: English; Trade Name: NSC-85998; Generic Name: Streptozotocin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin; References: 43; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Clinical experience with streptozotocin (NSC-85998) in 52 patients with metastatic islet cell carcinoma is discussed. The drug was given I.V. in 44 patients and intra-arterially in 8 patients, most often on a weekly schedule of 0.6 to 1.0 g./sq. m. Biochemical responses were seen in 64% of evaluable cases, and measurable disease responses were seen in 50% of these cases. Insulin responses occurred 2 to 3 weeks after drug administration at a total dose of about 2 to 4 g./sq. m. A significant increase in 1-year survival rate and a doubling of median survival were shown for the responders as compared with the nonresponders. Acute toxicity, consisting of nausea and vomiting, was observed in 98% of the cases, whereas renal or hepatic toxicity was seen in 65% and 67% of the cases, respectively. Hematological toxicity, observed in 20% of the cases, was mild. Renal and hepatic toxicity were usually reversible, but 5 patients died in renal failure.
KW  - Streptozotocin--carcinomas-;
KW  - Antineoplastic agents--streptozotocin--carcinomas, metastatic islet cell, therapy, in patients;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Aptekar, R. G.;
AU  - Atkinson, J. P.;
AU  - Decker, J. L.;
AU  - Wolff, S. M.;
AU  - Chu, E. W.;
T1  - Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant disease
CT  - Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant disease
JO  - Arthritis and Rheumatism (USA)
JF  - Arthritis and Rheumatism (USA)
Y1  - 1973/07/01/
VL  - 16
IS  - Jul-Aug
SP  - 461
EP  - 467
SN  - 00043591
AD  - National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigation, The National Cancer Institute Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-0997; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 22; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Jack Rosenberg
N2  - A discussion of bladder toxicity in 46 patients, resulting from chronic oral cyclophosphamide therapy in nonmalignant disease, is presented. Over 600 months of oral cyclophosphamide therapy was given to patients with systemic lupus erythematosis (SLE), Wegener's granulomatosis, rheumatoid arthritis, idiopathic nephrotic syndrome, and hypereosinophilic syndrome. If an abnormal urinalysis was noted, urine cytology was done on a double-voided specimen. Thirteen (28%) had urinary bladder complications. Three distinct problems were apparent: chronic cystitis in 6, abnormal urine cytology in 3, acute hemorrhagic cystitis in 4. These patterns could not have been segregated without urine cytology. Persistence of abnormal findings may lead to irreversible bladder toxicity.
KW  - Cyclophosphamide--toxicity-;
KW  - Toxicity--cyclophosphamide--bladder, in nonmalignant disease therapy, in patients;
KW  - Antineoplastic agents--cyclophosphamide--toxicity, bladder, nonmalignant disease therapy, in patients;
KW  - Drugs, adverse reactions--cyclophosphamide--bladder, complications, nonmalignant disease therapy, in patients;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gillette, J. R.;
AU  - Menard, R. H.;
AU  - Stripp, B.;
T1  - Active products of fetal drug metabolism
CT  - Active products of fetal drug metabolism
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1973/07/01/
VL  - 14
IS  - Jul-Aug
SP  - 680
EP  - 692
SN  - 00099236
AD  - Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 11-2772; Language: English; References: 41; Journal Coden: CLPTAT; Section Heading: Drug Metabolism and Body Distribution
N2  - Theoretical relationships between the activities of placental and fetal enzymes and their ability to perturb the steady-state tissue levels of drugs have been calculated. Although the calculations suggest that the activities of the enzymes that metabolize desipramine and 3,4-benzpyrene in human placentas and fetuses may be high enough to decrease the steady-state concentrations of these substances, the rates of metabolism of most drugs are probably too slow to affect the fetal levels of most lipid-soluble compounds. It is also probable that the rate of bromobenzene metabolism by cytochrome P-450 enzymes in fetal liver is too slow to cause liver necrosis caused by this toxicant. Nevertheless, it is possible that enzymes that catalyze the reduction of nitro compounds, such as nitrofurazone, to hydroxylamino derivatives may mediate various drug toxicities in fetuses.
KW  - Metabolism--drugs--fetal, discussion;
KW  - Placental transfer--drugs--metabolism, fetal, discussion;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Nebert, D. W.;
T1  - Use of fetal cell culture as an experimental system for predicting drug metabolism in the intact animal
CT  - Use of fetal cell culture as an experimental system for predicting drug metabolism in the intact animal
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1973/07/01/
VL  - 14
IS  - Jul-Aug
SP  - 693
EP  - 699
SN  - 00099236
AD  - Section on Developmental Pharmacology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland
N1  - Accession Number: 11-2798; Language: English; References: 44; Journal Coden: CLPTAT; Section Heading: Methodology; Abstract Author: Monte S. Cohon
N2  - It is postulated that teratogenicity of various drugs in a certain strain or species of animal may be predicted if one is able to quantitate certain parameters of a compound's metabolism in fetal cell cultures from that particular strain or species.
KW  - Teratogenicity--drugs--prediction, in fetal cell cultures, in animal strains;
KW  - Toxicity--drugs--prediction, in fetal cell cultures, in animal strains;
KW  - Metabolism--drugs--teratogenicity, prediction, in fetal cell cultures, in animal strains;
KW  - Methodology--teratogenicity--drugs, prediction, in fetal cell cultures, in animal strains;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - Werblin, T. P.
AU  - Kim, Y. T.
AU  - Mage, Rose
AU  - Benacerraf, B.
AU  - Siskind, G. W.
T1  - The Generation of Antibody Diversity I. STUDIES ON THE POPULATION DISTRIBUTION OF  ANTI-DNP ANTIBODY AFFINITIES AND ON THE INFLUENCE OF ALLOTYPE ON ANTIBODY AFFINITY AND CONCENTRATION.
JO  - Immunology
JF  - Immunology
Y1  - 1973/07//
VL  - 25
IS  - 1
M3  - Article
SP  - 17
EP  - 32
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A genetically diverse population of sixty-four rabbits has been studied with respect to the concentration and affinity of anti-DNP antibody produced over the course of a year following a single injection of DNP-BGG. It was found that the responses of male and female members of the population were essentially identical throughout the entire course of the immune response. The effect of allotype on the concentration and affinity of the antibody produced was examined. It was observed that the b6 allotype was associated with the production of decreased concentrations of antibody, the b5 allotype with the production of increased concentrations of antibody, the a1 allotype with the production of high affinity antibody and the a2 allotype with the production of low affinity antibody when compared to the remainder of the population. A tendency was also seen for individuals to maintain, over the course of time, their relative position in the population with respect to the concentration and affinity of the antibody they produce. Finally, it was observed that the mean affinity of the population continually shifted towards high affinity over the period of observation and that the standard deviation of the population with regard to the affinity of the antibody produced decreased with time. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIBODY diversity
KW  - IMMUNOGLOBULIN allotypes
KW  - IMMUNOGLOBULINS
KW  - IMMUNE response
KW  - IMMUNOLOGY
KW  - IMMUNOGENETICS
N1  - Accession Number: 13437927; Werblin, T. P. 1 Kim, Y. T. 1 Mage, Rose 1 Benacerraf, B. 1 Siskind, G. W. 1; Affiliation:  1: Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York 10021, Department of Pathology, New York University School of Medicine, New York, 10016; Laboratory of Immunology, National Institute of Allergy of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 20014, and Department of Pathology, Harvard Medical School, Boston, U.S.A.; Source Info: Jul73, Vol. 25 Issue 1, p17; Subject Term: ANTIBODY diversity; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: IMMUNOGENETICS; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donnelly, Edward F.
AU  - Murphy, Dennis L.
T1  - PRIMARY AFFECTIVE DISORDER: MMPI DIFFERENCES BETWEEN UNIPOLAR AND BIPOLAR DEPRESSED SUBJECTS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1973/07//
VL  - 29
IS  - 3
M3  - Article
SP  - 303
EP  - 306
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article presents a study, which focuses on the primary affective disorder. This study also compares unipolar and bipolar Ss hospitalized for depression with the MMPI. In addition, behavioral ratings for these two groups were obtained simultaneously on the Bunney-Hamburg depression scale and compared with the MMPI results. The results of the study indicate that groups of unipolar and bipolar Ss have significantly different scores on the MMPI during depressive episodes, further evidence is provided in support of the role of mania in delineating a subgroup of Ss with primary affective disorder who also demonstrate distinctive clinical, familial and biological features.
KW  - AFFECTIVE disorders
KW  - PATHOLOGICAL psychology
KW  - PSYCHOSES
KW  - MENTALLY ill
KW  - HUMAN behavior
KW  - RESEARCH
N1  - Accession Number: 15903694; Donnelly, Edward F. 1 Murphy, Dennis L. 1; Affiliation:  1: National Institute of Mental Health, Bethesda, Maryland.; Source Info: Jul1973, Vol. 29 Issue 3, p303; Subject Term: AFFECTIVE disorders; Subject Term: PATHOLOGICAL psychology; Subject Term: PSYCHOSES; Subject Term: MENTALLY ill; Subject Term: HUMAN behavior; Subject Term: RESEARCH; Number of Pages: 4p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chess, L.;
AU  - Bock, G. N.;
AU  - Ungaro, P. C.;
AU  - Buchholz, D. H.;
AU  - Mardiney, M. R., Jr.;
T1  - Immunologic effects of BCG in patients with malignant melanoma: specific evidence for stimulation of the secondary immune response
CT  - Immunologic effects of BCG in patients with malignant melanoma: specific evidence for stimulation of the secondary immune response
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1973/07/01/
VL  - 51
IS  - Jul
SP  - 57
EP  - 65
SN  - 00278874
AD  - Section of Immunology and Cell Biology, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland 21211
N1  - Accession Number: 11-2055; Language: English; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2  - The effects of BCG vaccine on immunologic function were assessed in 4 patients with malignant melanoma. Cell-associated immune function was quantitatively measured in vitro by the incorporation of H-thymidine into frozen-stored lymphocytes in response to specific antigens (both related and unrelated to BCG), allogeneic lymphocytes, and phytohemagglutinin (PHA). In vivo, cell-mediated immunity was determined by delayed hypersensitivity skin reactions to various antigens. Serum IgG, IgM, IgA, and C\PR/3 (complement) levels were quantitated. BCG administration significantly augmented antigen-induced incorporation of H-thymidine in 3 patients, with little or no effect on responses to allogeneic lymphocytes or PHA. BCG selectively increased serum IgG levels in the same 3 patients. IgA, IgM, or complement levels were not enhanced. All patients converted their purified protein derivative (PPD) skin-test reactivity from negative to positive during therapy, and in 2 patients candida skin reactivity appeared. These effects on cell-associated immune functions, immunoglobulin, complement levels, and in vivo-delayed hypersensitivity were consistent with the hypothesis that BCG primarily augments host responsiveness to antigens to which the host has previously been exposed. No effects on the primary immune response was detected. The one patient who did not respond to BCG by cell-associated humoral immunologic enhancement had metastatic disease before initiation of study, which then rapidly progressed. Clinically, 2 of the 3 patients reacting immunologically, in addition to the one patient who failed to respond, developed progressive metastatic disease during therapy. One patient continues to respond immunologically and remains free of progressive disease.
KW  - BCG vaccines--melanomas-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Heston, W. E.;
AU  - Valahakis, G.;
AU  - Desmukes, B.;
T1  - Effects of the antifertility drug Enovid in five strains of mice, with particular regard to carcinogenesis
CT  - Effects of the antifertility drug Enovid in five strains of mice, with particular regard to carcinogenesis
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1973/07/01/
VL  - 51
IS  - Jul
SP  - 209
EP  - 222
SN  - 00278874
AD  - Laboratory of Biology, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-1009; Language: English; Trade Name: Enovid; Generic Name: Mestranol; Chemical Name: Norethynodrel--68-23-5 Mestranol--72-33-3; Therapeutic Class: (68:12); AHFS Class: Contraceptives, oral norethynodrel, combination, mestranol (68:12); AHFS Class: Contraceptives, oral mestranol, combination, norethynodrel; Section Heading: Toxicity
N2  - The antifertility drug, Enovid (norethynodrel, combination, mestranol) was tested for possible carcinogenicity in female mice of 5 specially selected strains. The drug was fed at 3 dose levels: 5 mcg. Enovid/g. of food that did not prevent reproduction, 10 mcg./g. that prevented some females from reproducing, 20 mcg./g. that prevented all females from reproducing. The results emphasized that inbred strains of mice differed in their response to Enovid. Treatment reduced the gain in weight of all strains. It had no effect on life span in one strain, but in 2 strains life span was lengthened and in 2 shortened because of the effect on tumors or other lesions. Cervical and vaginal lesions showing invasion of the epithelium into the stroma with varying degrees of progression were observed but limited essentially to one strain. Highest incidence in progression occurred in the group treated with the highest dose of Enovid. None were observed as tumors and none had extended beyond the vaginal wall or showed any evidence of having metastasized. Occurrence of ovarian tumors did not increase at these dosage levels and mammary tumors seemed to be inhibited in the treated groups. Hepatomas seemed to be inhibited, probably due to growth effects, and in another strain there was some inhibition of adrenocortical adenomas.
KW  - Norethynodrel--combination, mestranol-;
KW  - Mestranol--combination, norethynodrel-;
KW  - Contraceptives, oral--norethynodrel, combination, mestranol--effects, weight, life span, and carcinogenicity, in mice;
KW  - Contraceptives, oral--mestranol, combination, norethynodrel--effects, weight, life span, and carcinogenicity, in mice;
KW  - Toxicity--norethynodrel, combination, mestranol--studies, carcinogenicity, in mice;
KW  - Toxicity--mestranol, combination, norethynodrel--studies, carcinogenicity, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Leeds, A. A.;
T1  - International reference center for information on psychotropic drugs: activities, plans, and news briefs
CT  - International reference center for information on psychotropic drugs: activities, plans, and news briefs
JO  - Psychopharmacol. Bull.
JF  - Psychopharmacol. Bull.
Y1  - 1973/07/01/
VL  - 9
IS  - Jul
SP  - 1
EP  - 0
AD  - International Reference Center for Information on Psychotropic Drugs, Psychopharmacology Research Branch, National Institute of Mental Health, Parklawn Building, Room 9-105, 5600 Fishers Lane, Rockville, Maryland 20852
N1  - Accession Number: 11-0383; Language: English; Journal Coden: PSYBB9; Section Heading: Information Processing and Literature; Abstract Author: Douglas L. Thompson
N2  - The activities of the WHO Information Network relating to information on psychotropic drugs over the past 5 years are reviewed. The main purpose of this network is to direct inquiries from researchers to persons or institutions where specific information relating to these drugs may be obtained. A list of countries having collaborative or national reference centers on psychopharmacology is included. A classification of psychotropic drugs used by the international reference center network is included. Also included is a form for recording information relating to these drugs.
KW  - Drug information--psychotherapeutic agents--International Reference Center;
KW  - International Reference Center--psychotherapeutic agents--discussion;
KW  - Psychotherapeutic agents--International Reference Center--discussion;
KW  - Nomenclature--psychotherapeutic agents--used by International Reference Center;
KW  - Forms--drug information--psychotherapeutic agents, used by International Reference Center;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - McGlashan, T. H.;
AU  - Guy, W. H.;
AU  - Davis, D.;
AU  - Levine, J.;
T1  - Research plan report: revised form and information retrieval system
CT  - Research plan report: revised form and information retrieval system
JO  - Psychopharmacol. Bull.
JF  - Psychopharmacol. Bull.
Y1  - 1973/07/01/
VL  - 9
IS  - Jul
SP  - 53
EP  - 72
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland
N1  - Accession Number: 11-0384; Language: English; Journal Coden: PSYBB9; Section Heading: Information Processing and Literature; Abstract Author: Douglas L. Thompson
N2  - The Research Plan Report concept, which is in essence a form for documenting the protocol for psychotropic drug trials, is discussed. The second revision of the original research plan report is described. A copy of the forms used in this report is included.
KW  - Drug information--psychotherapeutic agents--discussion, Research Plan Report concept;
KW  - Psychotherapeutic agents--drug information--discussion, Research Plan Report concept;
KW  - Forms--drug information--psychotherapeutic agents, Research Plan Report concept;
KW  - Research--psychotherapeutic agents--Research Plan Report concept, discussion;
KW  - Methodology--drug information--psychotherapeutic agents, Research Plan Report concept;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Schechter, Gail
AU  - Buchsbaum, Monte
T1  - The Effects of Attention, Stimulus Intensity, and Individual Differences on the Average Evoked Response.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1973/07//
VL  - 10
IS  - 4
M3  - Article
SP  - 392
EP  - 400
SN  - 00485772
AB  - The effects of shifting attention toward or away from visual or auditory stimuli of varying intensities were studied using average evoked responses (AERs) in 24 normal human volunteers. Ss were asked to attend to visual or auditory stimuli of four intensities (randomly presented) or to ignore the lights and tones and do mental arithmetic. For visual stimuli, attentional effects were largest at low intensities whereas for auditory stimuli equal effects were shown across intensities. Similar individual rates of increase of AER amplitude with increasing intensity were observed for both visual and auditory stimuli when attentional conditions were controlled. These results suggest that some general intensity processing response is reflected in the AER and that it is important to control attention in AER experiments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STIMULUS intensity
KW  - PERCEPTION
KW  - EVOKED response audiometry
KW  - INDIVIDUAL differences
KW  - INTEREST (Psychology)
KW  - ATTENTION
KW  - Attention
KW  - Average evoked response
KW  - Individual differences.
KW  - Stimulus intensity
N1  - Accession Number: 11083143; Schechter, Gail 1 Buchsbaum, Monte 1; Affiliation:  1: Unit of Psychophysiology, Laboratory of Psychology, National Institute of Mental Health, Bethesda.; Source Info: Jul1973, Vol. 10 Issue 4, p392; Subject Term: STIMULUS intensity; Subject Term: PERCEPTION; Subject Term: EVOKED response audiometry; Subject Term: INDIVIDUAL differences; Subject Term: INTEREST (Psychology); Subject Term: ATTENTION; Author-Supplied Keyword: Attention; Author-Supplied Keyword: Average evoked response; Author-Supplied Keyword: Individual differences.; Author-Supplied Keyword: Stimulus intensity; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-8986.ep11083143
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goldschmidt, Walter
T1  - The Brideprice of the Sebei.
JO  - Scientific American
JF  - Scientific American
Y1  - 1973/07//
VL  - 229
IS  - 1
M3  - Article
SP  - 74
EP  - 85
SN  - 00368733
AB  - Presents the findings of a study on the brideprice contracts of Sebei in Uganda.  Purpose of the brideprice payment being given by a man to the family of his bride; Principal spokesman of the bride in contract negotiations; Specific items involved in a brideprice contract.
KW  - Bride price
KW  - Sapiny (African people)
KW  - Dowry
KW  - Marriage brokerage
KW  - Uganda
N1  - Accession Number: 21149867; Goldschmidt, Walter 1,2; Affiliations: 1: Professor, Anthropology and Psychiatry, University of California, Los Angeles; 2: Senior Science Fellow, National Institute of Mental Health; Issue Info: Jul1973, Vol. 229 Issue 1, p74; Subject Term: Bride price; Subject Term: Sapiny (African people); Subject Term: Dowry; Subject Term: Marriage brokerage; Subject: Uganda; Number of Pages: 12p; Illustrations: 8 Graphs, 2 Maps; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Evarts, Edward V.
T1  - BRAIN MECHANISMS IN MOVEMENT.
JO  - Scientific American
JF  - Scientific American
Y1  - 1973/07//
VL  - 229
IS  - 1
M3  - Article
SP  - 96
EP  - 103
SN  - 00368733
AB  - Focuses on the part of the brain that controls and integrates muscular movements.  Implications of the discovery that muscular contraction could be produced by the electrical stimulation of a small region of the cerebral cortex; Difficulties faced by neurologists in studying volitional movement; Components of the brain that initiate motor response.
KW  - Brain
KW  - Motor ability
KW  - Cerebral cortex
KW  - Muscle contraction
KW  - Human mechanics
N1  - Accession Number: 21149869; Evarts, Edward V. 1; Affiliations: 1: Member, Laboratory of Neurophysiology of the National Institute of Mental Health; Issue Info: Jul1973, Vol. 229 Issue 1, p96; Subject Term: Brain; Subject Term: Motor ability; Subject Term: Cerebral cortex; Subject Term: Muscle contraction; Subject Term: Human mechanics; Number of Pages: 8p; Illustrations: 10 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2013-41574-012
AN  - 2013-41574-012
AU  - Scrofani, Philip J.
AU  - Suziedelis, Antanas
AU  - Shore, Milton F.
T1  - Conceptual ability in Black and White children of different social classes: An experimental test of Jensen's hypothesis.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/07//
VL  - 43
IS  - 4
SP  - 541
EP  - 553
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-41574-012. PMID: 4716672 Partial author list: First Author & Affiliation: Scrofani, Philip J.; Catholic University of America, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the Medical Society of Saint Elizabeth's Hospital, 34th. Conference Note: Portions were presented at the aforementioned conference. Major Descriptor: Childhood Development; Cognitive Ability; Concept Formation; Racial and Ethnic Differences; Social Class. Minor Descriptor: Blacks; Whites. Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Tests & Measures: Peabody Picture Vocabulary Test-Modified Version. Methodology: Empirical Study; Quantitative Study. Page Count: 13. Issue Publication Date: Jul, 1973. 
AB  - Jensen's theory of inherent conceptual ability differences between SES groups was tested by training children of all SES levels in concept formation. A significant number of low-SES children were able to achieve middle-class performance levels in conceptual tasks. The ability to profit from training was related to the developmental measures of cognition. No sex, age, or racial differences were found. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - conceptual ability
KW  - Black children
KW  - White children
KW  - social classes
KW  - racial differences
KW  - 1973
KW  - Childhood Development
KW  - Cognitive Ability
KW  - Concept Formation
KW  - Racial and Ethnic Differences
KW  - Social Class
KW  - Blacks
KW  - Whites
KW  - 1973
U1  - Sponsor: National Institute of Mental Health, Saint Elizabeth's Hospital, Division of Clinical ResfJarch and Training, US. Recipients: No recipient indicated
DO  - 10.1111/j.1939-0025.1973.tb00823.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41574-033
AN  - 2013-41574-033
AU  - Dent, James K.
T1  - Review of Wechsler's measurement and appraisal of adult intelligence: 5th & enlarged edition and The clinical interpretation of the Wechsler Adult Intelligence Scale.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/07//
VL  - 43
IS  - 4
SP  - 685
EP  - 686
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41574-033. Partial author list: First Author & Affiliation: Dent, James K.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Intelligence; Psychometrics; Test Construction; Wechsler Adult Intelligence Scale. Minor Descriptor: Cognitive Appraisal. Classification: Clinical Psychological Testing (2224); Psychological & Physical Disorders (3200). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Matarazzo, Joseph D. Wechsler's measurement and appraisal of adult intelligence: 5th & enlarged edition=Baltimore: Williams & Wilkins. 572 pp. $15.75; 1972. Lee Zimmerman, Ira; Woo-Sam, James; Glasser, Alan J. The clinical interpretation of the Wechsler Adult Intelligence Scale=New York: Grune & Stratton. 224 pp. $7.95; 1973. Page Count: 2. Issue Publication Date: Jul, 1973. 
AB  - Reviews the books, Wechsler's Measurement and Appraisal of Adult Intelligence: 5th & Enlarged Edition by Joseph D. Matarazzo (see record [rid]1973-26037-000[/rid]) and The Clinical Interpretation of the Wechsler Adult Intelligence Scale by Ira Lee Zimmerman, James Woo-Sam, and Alan J. Glasser (see record [rid]1973-28141-000[/rid]). In these two books it can he presumed that we have the independent selections of the authors, since Matarazzo is not mentioned in the index of Zimmerman and Woo-Sam and they are not mentioned in his. The results of these labors are two books quite different in their approaches and in their content. Clinicians using the WAIS will need to be familiar with both. Both books can be faulted for not telling us more about how they chose studies for inclusion. Neither of them attempts to assess future directions, either in the further development of the WAIS or in its uses in research and practice. But these faults do not really detract from their important and complementary accomplishments in bringing order to a large volume of empirical work. The reviewer suspects that both books' pages will be well-thumbed by clinicians until still newer integrations are available. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adult intelligence appraisal
KW  - Wechsler Adult Intelligence Scale
KW  - psychometrics
KW  - test development
KW  - clinical interpretation
KW  - 1973
KW  - Clinical Psychology
KW  - Intelligence
KW  - Psychometrics
KW  - Test Construction
KW  - Wechsler Adult Intelligence Scale
KW  - Cognitive Appraisal
KW  - 1973
U2  - Matarazzo, Joseph D. (1972); Wechsler's measurement and appraisal of adult intelligence: 5th & enlarged edition; Baltimore: Williams & Wilkins. 572 pp. $15.75
U2  - Lee Zimmerman, Ira; Woo-Sam, James; Glasser, Alan J. (1973); The clinical interpretation of the Wechsler Adult Intelligence Scale; New York: Grune & Stratton. 224 pp. $7.95
DO  - 10.1037/h0097705
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Brady, R. O.;
AU  - Tallman, J. F.;
AU  - Johnson, W. G.;
AU  - Gal, A. E.;
AU  - Leahy, W. R.;
AU  - \ET/;
T1  - Replacement therapy for inherited enzyme deficiency: use of purified ceramidetrihexosidase in Fabry's disease
CT  - Replacement therapy for inherited enzyme deficiency: use of purified ceramidetrihexosidase in Fabry's disease
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1973/07/05/
VL  - 289
IS  - Jul 5
SP  - 9
EP  - 4
SN  - 00284793
AD  - Building 10, Room 3D-03, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 10-4051; Language: English; Therapeutic Class: (44:00); AHFS Class: Enzymes ceramidetrihexosidase; References: 30; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Ceramidetrihexosidase, which is lacking in patients with Fabry's disease, was highly purified from human placental tissue and administered I.V. to 2 patients with Fabry's disease. The patients tolerated the procedure very well. The enzyme was rapidly cleared from the blood and was taken up to a major extent by the liver. In one patient, the level of circulating ceramidetrihexoside decreased from 53 to 22 nmoles/10 ml. of plasma 40 min. after the enzyme was administered. In the other, who received 40% less enzyme, the level of circulating ceramidetrihexoside decreased from 67 to 45 nmoles/10 ml. of plasma. Infusions of normal fresh plasma or leukocytes and platelets suspended in plasma yielded results resembling the effect obtained with purified enzyme. Plasma infusion had no demonstrable effect.
KW  - Ceramidetrihexosidase--Fabry's disease-;
KW  - Enzymes--ceramidetrihexosidase--Fabry's disease, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - GUYTON, DAVID L.
AU  - HAMBRECHT, F. TERRY
T1  - Capacitor Electrode Stimulates Nerve or Muscle without Oxidation-Reduction Reactions.
JO  - Science
JF  - Science
Y1  - 1973/07/06/
VL  - 181
IS  - 4094
M3  - Article
SP  - 74
EP  - 76
SN  - 00368075
AB  - Porous tantalum disks, available as "slugs" from the capacitor industry, have large available surface area and a thin insulating coating of tantalum pentoxide. When implanted, they fill with extracellular fluid and operate as capacitor-stimulating electrodes having high capacitance per unit volume. Capable of stimulating excitable tissue without generating electrochemical by-products, these electrodes should provide a safer interface between neural prosthetic devices and human tissue. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158728; GUYTON, DAVID L. 1; HAMBRECHT, F. TERRY 1; Affiliations: 1: Laboratory of Neural Control, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/ 6/1973, Vol. 181 Issue 4094, p74; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Douglass, Carl D.
AU  - James, John C.
T1  - Support of New Principal Investigators by NIH: 1966 to 1972.
JO  - Science
JF  - Science
Y1  - 1973/07/20/
VL  - 181
IS  - 4096
M3  - Article
SP  - 241
EP  - 244
SN  - 00368075
N1  - Accession Number: 85362867; Douglass, Carl D. 1; James, John C. 2; Affiliations: 1: Deputy director, Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20014; 2: Chief, Research Analysis and Evaluation Branch, Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p241; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LUST, W. DAVID
AU  - PASSONNEAU, JANET V.
AU  - VEECH, RICHARD L.
T1  - Cyclic Adenosine Monophosphate, Metabolites, and Phosphorylase in Neural Tissue: A Comparison of Methods of Fixation.
JO  - Science
JF  - Science
Y1  - 1973/07/20/
VL  - 181
IS  - 4096
M3  - Article
SP  - 280
EP  - 282
SN  - 00368075
AB  - Fixation of rat brain tissue by freeze-blowing, microwave irradiation, iimmersion of whole rats in liquid nitrogen, and decapitation into liquid nitrogen indicates that postmortem changes in metabolites and enzyme forms are minimal in freeze-blown brains. Cyclic adenosine monophosphate levels are lowest in microwave-irradiated brains, which has been interpreted by some investigators to indicate rapid fixation and minimal anoxia. However, the changes in phosphocreatine, adenosine triphosphate, lactate, and phosphorylase clearly demonstrate that fixation by freeze-blowing or immersion in liquid nitrogen more closely approximate the state in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85362894; LUST, W. DAVID 1; PASSONNEAU, JANET V. 1; VEECH, RICHARD L. 2; Affiliations: 1: National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 2: National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p280; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - UPHOFF, DELTA E.
AU  - WHITTINGHAM, D. G.
AU  - LEIBO, S. P.
AU  - MAZUR, PETER
T1  - Maternal Influences on Mouse Embryos and Preservation of Mutant Strains by Freezing.
JO  - Science
JF  - Science
Y1  - 1973/07/20/
VL  - 181
IS  - 4096
M3  - Article
SP  - 287
EP  - 288
SN  - 00368075
N1  - Accession Number: 85362897; UPHOFF, DELTA E. 1; WHITTINGHAM, D. G. 2; LEIBO, S. P. 3; MAZUR, PETER 3; Affiliations: 1: Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland 20014; 2: Physiological Laboratory, Cambridge University, Cambridge, England; 3: Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p287; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Blye, R. P.;
T1  - Use of estrogens as postcoital contraceptive agents
CT  - Use of estrogens as postcoital contraceptive agents
JO  - American Journal of Obstetrics and Gynecology (USA)
JF  - American Journal of Obstetrics and Gynecology (USA)
Y1  - 1973/08/01/
VL  - 116
IS  - Aug 1
SP  - 1044
EP  - 1050
SN  - 00029378
AD  - Contraceptive Development Branch, Center for Population Research, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-3968; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; Therapeutic Class: (68:12); AHFS Class: Contraceptives postcoital diethylstilbestrol; References: 52; Journal Coden: AJOGAH; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Sufficient evidence has accrued to indicate that daily administration of 50 mg. of diethylstilbestrol, 30 mg. of conjugated equine estrogens or 5 mg. of ethinyl estradiol for 5 consecutive days is probably effective in preventing pregnancy if instituted within 72 hours of unprotected midcycle coital exposure.
KW  - Diethylstilbestrol--contraceptives postcoital-;
KW  - Estrogenic substances--conjugated--contraceptives postcoital, dosage schedules, in women;
KW  - Ethinyl estradiol--contraceptives postcoital--dosage schedules, in women;
KW  - Contraceptives postcoital--ethinyl estradiol--dosage schedules, in women;
KW  - Contraceptives postcoital--diethylstilbestrol--dosage schedules, in women;
KW  - Contraceptives postcoital--estrogenic substances--conjugated, dosage schedules, in women;
KW  - Dosage schedules--diethylstilbestrol--contraceptives, postcoital, in women;
KW  - Dosage schedules--estrogenic substances--conjugated, postcoital contraceptives, in women;
KW  - Dosage schedules--ethinyl estradiol--contraceptives, postcoital, oral, in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Padilla, Elena
AU  - Goldston, Steven E.
T1  - Exposure to Mental Health Training in Schools of Public Health.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/08//
VL  - 63
IS  - 8
M3  - Article
SP  - 710
EP  - 714
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the issue of mental health training in schools of public health. Mental health or mental hygiene has generally been included in the curricula of schools of public health. Two major purposes have guided the development of mental health training programs in schools of public health to broaden and improve the functional capacity of health manpower, and to provide mental health training sequences for students wishing to specialize in the mental health field. A total of 3,115 respondents replied to a questionnaire mailed in the summer of 1968 to 4,459 graduates from those schools, who were living or working throughout the U.S. and abroad. Contacts with psychiatrists ranked highest among respondents from nine schools. Over one-half of the contacts reported by respondents from Columbia, Illinois and Tulane, Louisiana were with psychiatrists. Roughly from one-third to two-thirds of the respondents were aware of having been exposed to mental health training while attending a school of public health.
KW  - Public health
KW  - Mental health
KW  - Education
KW  - Occupational training
KW  - Psychiatrists
KW  - United States
KW  - Health (mental)
KW  - Public health, schools
KW  - schools
N1  - Accession Number: 7971035; Padilla, Elena 1; Goldston, Steven E. 2; Affiliations: 1: Consultant, National Institute of Mental Health, 5600 Fishers Lane, Rockville, Maryland 20852.; 2: Coordinator for Primary Prevention Programs, National Institute of Mental Health, 5600 Fishers Lane, Rockville, Maryland 20852.; Issue Info: Aug1973, Vol. 63 Issue 8, p710; Thesaurus Term: Public health; Subject Term: Mental health; Subject Term: Education; Subject Term: Occupational training; Subject Term: Psychiatrists; Subject: United States; Author-Supplied Keyword: Health (mental); Author-Supplied Keyword: Public health, schools; Author-Supplied Keyword: schools; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Sherins, R. J.;
AU  - DeVita, V. T., Jr.;
T1  - Effect of drug treatment for lymphoma on male reproductive capacity
CT  - Effect of drug treatment for lymphoma on male reproductive capacity
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1973/08/01/
VL  - 79
IS  - Aug
SP  - 216
EP  - 220
SN  - 00034819
AD  - Reproduction Research Branch, National Institute of Child Health and Human Development; and the Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-0024; Language: English; References: 27; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity
N2  - The effect of combined therapy with antineoplastic agents on spermatogenesis was studied in 16 patients. Reproductive function was evaluated in men who had been treated with (1) a combination of nitrogen mustard (mechlorethamine), vincristine, procarbazine, and prednisone; (2) a similar combination, with methotrexate instead of procarbazine; (3) cyclophosphamide, vincristine, and prednisone; or (4) cyclophosphamide for lymphoma, were in remission, and had received no therapy for 6 months to 7 years. Although libido and potency were normal in all patients, 10 men were azoospermic, and testicular biopsy showed complete absence of germ cells; 2 men showed minimal evidence of spermatogenesis; and 4 men, in remission for 2 to 7 years, showed complete spermatogenesis at the time of their evaluation. Within each treatment group the men with evidence of normal germinal tissue were those who had been in remission longest for that group. These data suggest that spermatogenesis may return after extensive chemotherapy but that this is more likely to occur more than 2 years after drug treatment.
KW  - Antineoplastic agents--combined therapy--effects, male reproductive capacity, in patients;
KW  - Combined therapy--antineoplastic agents--effects, male reproductive capacity, in patients;
KW  - Toxicity--antineoplastic agents--studies, combined therapy, effects on male reproductive capacity, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - DeVita, V. T.;
AU  - Johnson, R. E.;
T1  - Hodgkin's disease in childhood
CT  - Hodgkin's disease in childhood
JO  - Blood
JF  - Blood
Y1  - 1973/08/01/
VL  - 42
IS  - Aug
SP  - 163
EP  - 174
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-3286; Language: English; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Prednisone--53-03-2 Procarbazine--671-16-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine, mechlorethamine, prednisone and procarbazine (10:00); AHFS Class: Antineoplastic agents prednisone, mechlorethamine, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents procarbazine, mechlorethamine, prednisone and vincristine; References: 22; Journal Coden: BLOOAW; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jimmie L. Hall
N2  - The treatment of 38 pediatric Hodgkin's disease patients with either intensive radiation or chemotherapy with mechlorethamine, vincristine, prednisone and procarbazine is described. Results suggest that intensive radiation for localized disease and combination chemotherapy for advanced disease are at present the preferred forms of therapy for Hodgkin's disease in children.
KW  - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW  - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW  - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW  - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW  - Radiation--Hodgkin's disease--localized, in children;
KW  - Antineoplastic agents--mechlorethamine, prednisone, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW  - Antineoplastic agents--vincristine, mechlorethamine, prednisone and procarbazine--Hodgkin's disease, therapy, in children;
KW  - Antineoplastic agents--prednisone, mechlorethamine, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW  - Antineoplastic agents--procarbazine, mechlorethamine, prednisone and vincristine--Hodgkin's disease, therapy, in children;
KW  - Combined therapy--mechlorethamine, prednisone, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW  - Combined therapy--vincristine, mechlorethamine, prednisone and procarbazine--Hodgkin's disease, therapy, in children;
KW  - Combined therapy--prednisone, mechlorethamine, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW  - Combined therapy--procarbazine, mechlorethamine, prednisone and vincristine--Hodgkin's disease, therapy, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Fales, Henry M
AU  - Feldmann, Richard J
AU  - Heller, Stephen R
AU  - Milne, G W A
T1  - A conversational mass spectral search system. 4. the evolution of a system for the retrieval of mass spectral information
JO  - Journal of Chemical Documentation
JF  - Journal of Chemical Documentation
Y1  - 1973/08//
VL  - 13
IS  - 3
M3  - Article
SP  - 130
EP  - 133
SN  - 00219576
AB  - A prototype of an interactive, conversational mass spectral search system, developed at the national institute of health, has been tested since september 1971 and is now being used by more than 200 scientists in the u.s. And canada. The response has led to management of the system being given to the mass spectrometry data centre, aldermaston, uk., for use by the international mass spectrometry community.
N1  - Accession Number: ISTA0803023; Fales, Henry M 1; Feldmann, Richard J; Heller, Stephen R; Milne, G W A; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: August 1973, Vol. 13 Issue 3, p130; Note: Update Code: 0800; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Edelson, Richard L.
AU  - Smith, Richard W.
AU  - Frank, Michael M.
AU  - Green, Ira
T1  - IDENTIFICATION OF SUBPOPULATIONS OF MONONUCLEAR CELLS IN CUTANEOUS INFILTRATES I. DIFFERENTIATION BETWEEN B CELLS, T CELLS, AND HISTIOCYTES.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1973/08//
VL  - 61
IS  - 2
M3  - Article
SP  - 82
EP  - 89
SN  - 0022202X
AB  - Differentiation between bone marrow-derived lymphocytes (B cells), thymus-derived lymphocytes (T cells), and histiocytes has been achieved in tissue sections through utilization of known differences in cell membrane receptors. Sheep erythrocytes (E) were coated with either IgG or IgM antibody (A) to form IgG or IgM EA. IgM EA was incubated with mouse complement (C) to form IgM EAC. Cryosections were layered with 1gM EAC. 1gM EA. or lgG EA. and subpopulations of mononuclear cells could be distinguished from one another by the adherence or nonadherence of these reagents. B cells bound 1gM EAC. but not 1gM EA or EgG EA; histiocytes hound 1gM EAC and JgG EA. hut not 1gM EA; and F cells failed to hind any of these reagents. B cells were identified in a cutaneous leukemic infiltrate in a patient with B cell leukemia. Histiocytes were identified infiltrating the dermis and epidermis in a graft -versus- host reaction. A dermal lymphocytic infiltrate in a squamous cell carcinoma lesion did not bind IgO EA or 1gM EA. The remainder of the fresh tissue from this lesion was finely minced and filtered through a glass wool column. The lymphocytes in the filtrate were positive for human thymic lymphocyte antigen, establishing their T cell identity. It is therefore possible to distinguish between B cells, T cells, and histiocytes in skin lesions, this method should be valuable in the investigation of cutaneous mononuclear infiltrates through identification of effector cells, [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - MONONUCLEOSIS
KW  - THYMUS
KW  - MACROPHAGES
KW  - ERYTHROCYTES
KW  - CELL membranes
N1  - Accession Number: 12675403; Edelson, Richard L. 1 Smith, Richard W. 1 Frank, Michael M. 1 Green, Ira 1; Affiliation:  1: Immunology Branch, National Cancer Institute and Laboratory of Clinical Investigation, National Institutes of Heath, Betheshda, Maryland; Source Info: Aug73, Vol. 61 Issue 2, p82; Subject Term: LYMPHOCYTES; Subject Term: MONONUCLEOSIS; Subject Term: THYMUS; Subject Term: MACROPHAGES; Subject Term: ERYTHROCYTES; Subject Term: CELL membranes; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12675403
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levy, R. I.;
AU  - Rifkind, B. M.;
T1  - Lipid lowering drugs and hyperlipidemia
CT  - Lipid lowering drugs and hyperlipidemia
JO  - New Ethicals Med. Prog.
JF  - New Ethicals Med. Prog.
Y1  - 1973/08/01/
VL  - 10
IS  - Aug
SP  - 149
EP  - 177
AD  - Lipid Metabolism Branch, National Heart and Lung Institute, National Institutes, of Health, Bethesda, Maryland
N1  - Accession Number: 11-3034; Language: English; Chemical Name: Clofibrate--637-07-0; Publication Type: Review; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Douglas L. Thompson
N2  - Hyperlipidemia therapy is reviewed and the use of antilipemic agents as a supplement to dietary control is discussed. It was concluded that many drugs are effective but no drug works in all types of hyperlipoproteinemia. Cholestyramine is effective in type IIa, clofibrate is extremely effective in type III and it may sometimes be useful in types IV and V, but, when not contraindicated nicotinic acid is usually more effective.
KW  - Cholestyramine--hyperlipoproteinemia-;
KW  - Clofibrate--hyperlipoproteinemia-;
KW  - Nicotinic acid--hyperlipoproteinemia-;
KW  - Antilipemic agents--therapy--review, in patients;
KW  - Nutrition--hyperlipoproteinemia--therapy, with drugs, discussion, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Eddy, Nathan B.
AU  - May, Everette L.
T1  - The Search for a Better Analgesic.
JO  - Science
JF  - Science
Y1  - 1973/08/03/
VL  - 181
IS  - 4098
M3  - Article
SP  - 407
EP  - 414
SN  - 00368075
N1  - Accession Number: 85362946; Eddy, Nathan B.; May, Everette L. 1; Affiliations: 1: Chief of medicinal chemistry, Laboratory of Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/ 3/1973, Vol. 181 Issue 4098, p407; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LIEBER, M. M.
AU  - LIVINGSTON, D. M.
AU  - TODARO, G. J.
T1  - Superinduction of Endogenous Type C Virus by 5-Bromodeoxyuridine from Transformed Mouse Clones.
JO  - Science
JF  - Science
Y1  - 1973/08/03/
VL  - 181
IS  - 4098
M3  - Article
SP  - 443
EP  - 444
SN  - 00368075
AB  - Certain transformed subclones of the mouse cell line BALB/3T3 release 5 to 15 times more type C virus per cell than the parent cell line after treatment with 5-bromodeoxyuridine. Virus release begins within 8 hours and exponentially increases for the first 24 to 48 hours. Superinducibility is associated with the transformed phenotype. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85362965; LIEBER, M. M. 1; LIVINGSTON, D. M. 1; TODARO, G. J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/ 3/1973, Vol. 181 Issue 4098, p443; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PETERS, ROBERT L.
AU  - SPAHN, GERARD J.
AU  - RABSTEIN, LOUISE S.
AU  - KELLOFF, GARY J.
AU  - HUEBNER, ROBERT J.
T1  - Murine C-type RNA Virus from Spontaneous Neoplasms: in vitro Host Range and Oncogenic Potential.
JO  - Science
JF  - Science
Y1  - 1973/08/17/
VL  - 181
IS  - 4100
M3  - Article
SP  - 665
EP  - 667
SN  - 00368075
AB  - Strain BALB/c mice harbor at least two host range variants of marine leukemia virus. One variant, which is host-cell tropic, is the predominant isolate from neoplastic tissues and produced lymphoreticular neoplasms when injected into BALB/c newborn mice. A second variant, whicht is isolated throughout life, grows poorly in host embryonic cells in culture and was not associated with lymphoreticular neoplasm induction when injected into newborn BALB/c mice [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85363064; PETERS, ROBERT L. 1; SPAHN, GERARD J. 1; RABSTEIN, LOUISE S. 1; KELLOFF, GARY J. 2; HUEBNER, ROBERT J. 2; Affiliations: 1: Microbiological Associates, Inc. Walkersville, Maryland 21793; 2: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/17/1973, Vol. 181 Issue 4100, p665; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Forrest, J. N.;
AU  - Heninger, G. R.;
AU  - Levy, S. T.;
T1  - Lithium-induced diabetes insipidus: manic symptoms, brain and electrolyte correlates, and chlorothiazide treatment
CT  - Lithium-induced diabetes insipidus: manic symptoms, brain and electrolyte correlates, and chlorothiazide treatment
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1973/09/01/
VL  - 130
IS  - Sep
SP  - 1014
EP  - 1018
SN  - 0002953X
AD  - Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06512
AD  - (Reprints: Adult Psychiatry Branch, Psychiatric Assessment Section, National Institute of Mental Health, Building 10, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 11-1406; Language: English; Chemical Name: Lithium--7439-93-2 Chlorothiazide--58-94-6; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium (40:28); AHFS Class: Diuretics chlorothiazide; References: 19; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Drug Evaluations
N2  - A patient with lithium-induced, vasopressin-insensitive diabetes insipidus was studied during 2 consecutive manic episodes that were successfully treated with lithium. Polyuria occurred several days after lithium-induced brain electrical changes were observed, and at serum lithium concentrations close to 1.0 meq./l. Polyuria began during a period of behavioral improvement and persisted after the manic symptoms subsided. Polyuria did not occur in association with serum lithium concentrations over 1.8 meq./l., and a 4-fold increase in sodium intake did not reduce the polyuria. Chlorothiazide reduced polyuria and permitted the patient to continue the lithium treatment.
KW  - Lithium--adverse reactions-;
KW  - Chlorothiazide--diabetes insipidus-;
KW  - Psychotherapeutic agents--lithium--adverse reactions, diabetes insipidus treated with chlorothiazide, in patient;
KW  - Drugs, adverse reactions--lithium--diabetes insipidus, treated with chlorothiazide, in patient;
KW  - Diuretics--chlorothiazide--diabetes insipidus, lithium induced, therapy, in patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Valdlamudi, S.;
AU  - Krishna, B.;
AU  - Reddy, V.;
AU  - Goldin, A.;
T1  - Schedule-dependent therapeutic synergism for L-asparaginase and methotrexate in leukemic (L5178y) mice
CT  - Schedule-dependent therapeutic synergism for L-asparaginase and methotrexate in leukemic (L5178y) mice
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1973/09/01/
VL  - 33
IS  - Sep
SP  - 2014
EP  - 2019
SN  - 00085472
AD  - Microbiological Associates, Inc., and National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-1475; Language: English; Chemical Name: Asparaginase--9015-68-3 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents asparaginase; References: 20; Journal Coden: CNREA8; Section Heading: Drug Interactions
N2  - In this study, therapeutic synergism was observed in combination chemotherapy of leukemia L5178Y with L-asparaginase (I) plus methotrexate (II) over a variety of treatment schedules. Therapeutic synergism occurred when a single dose of I was followed at varying times (immediately or up to 6 hr. later) by daily treatment with II. It was also observed when daily treatment with II was initiated just prior to or up to 6 hr. before a single treatment with I. Similarly, increases in survival time were observed in leukemic mice when daily treatment with II was initiated 4 days prior to a single dose of I on day 7. In one instance, the occurrence of therapeutic synergism was dependent upon the sequence of drug administration. Whereas therapeutic synergism was observed when mice bearing L5178Y leukemia were given 5 daily treatments of II followed 3 days later by 5 daily treatments of I; it did not occur when I preceded II on the same schedule. Treatment with II was found to be equally effective against leukemia L5178Y and its I resistant line.
KW  - Asparaginase--interactions-;
KW  - Methotrexate--interactions-;
KW  - Antineoplastic agents--methotrexate--interactions, asparaginase, synergism, leukemia therapy, schedule dependent, in mice;
KW  - Antineoplastic agents--asparaginase--interactions, methotrexate, synergism, leukemia therapy, schedule dependent, in mice;
KW  - Drug interactions--asparaginase and methotrexate--synergism, leukemia therapy, schedule dependent, in mice;
KW  - Drug interactions--methotrexate and asparaginase--synergism, leukemia therapy, schedule dependent, in mice;
KW  - Dosage schedules--methotrexate and asparaginase--leukemias, therapy, synergism, schedule dependent, in mice;
KW  - Dosage schedules--asparaginase and methotrexate--leukemias, therapy, synergism, schedule dependent, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Halverson, Charles F.
AU  - Jr.
AU  - Waldrop, Mary F.
T1  - The Relations of Mechanically Recorded Activity Level to Varieties of Preschool Play Behavior.
JO  - Child Development
JF  - Child Development
Y1  - 1973/09//
VL  - 44
IS  - 3
M3  - Article
SP  - 678
EP  - 681
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12115665; Halverson, Charles F. Jr. 1 Waldrop, Mary F. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Sep1973, Vol. 44 Issue 3, p678; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1467-8624.ep12115665
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Patel, Kantilal M.
AU  - Hoel, David G.
T1  - A Nonparametric Test for Interaction in Factorial Experiments.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1973/09//
VL  - 68
IS  - 343
M3  - Article
SP  - 615
SN  - 01621459
AB  - A measure of interaction in factorial experiments is introduced and the problem of estimating it and testing it for nullity is considered. The asymptotic power efficiencies are studied and Monte Carlo power comparisons are made when samples are drawn from normal and scale contaminated compound normal distributions. The proposed test showed improved power over the normal theory F test and other rank tests for moderately large samples taken from the heavy tailed distributions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NONPARAMETRIC statistics
KW  - DISTRIBUTION (Probability theory)
KW  - MONTE Carlo method
KW  - FACTOR analysis
KW  - FACTORIAL experiment designs
KW  - EXPERIMENTAL design
KW  - F-distribution
KW  - NUMERICAL analysis
N1  - Accession Number: 4607048; Patel, Kantilal M. 1; Hoel, David G. 2; Affiliations: 1: NIH Visiting Fellow, Biometry Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.; 2: Chief, Biometry Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.; Issue Info: Sep73, Vol. 68 Issue 343, p615; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MONTE Carlo method; Subject Term: FACTOR analysis; Subject Term: FACTORIAL experiment designs; Subject Term: EXPERIMENTAL design; Subject Term: F-distribution; Subject Term: NUMERICAL analysis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Weiss, George H.
T1  - Likelihood: An Account of the Statistical Concept of Likelihood and its Application to Scientific Inference (Book).
JO  - Operations Research
JF  - Operations Research
Y1  - 1973/09//Sep/Oct73
VL  - 21
IS  - 5
M3  - Book Review
SP  - 1172
EP  - 1173
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - Reviews the book "Likelihood: An Account of the Statistical Concept of Likelihood and its Application to Scientific Inference," by A. W. F. Edwards.
KW  - STATISTICS
KW  - NONFICTION
KW  - EDWARDS, A. W. F.
KW  - LIKELIHOOD: An Account of the Statistical Concept of Likelihood & Its Application to Scientific Inference (Book)
N1  - Accession Number: 8735954; Weiss, George H. 1; Affiliations: 1: National Institutes of Health; Issue Info: Sep/Oct73, Vol. 21 Issue 5, p1172; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: LIKELIHOOD: An Account of the Statistical Concept of Likelihood & Its Application to Scientific Inference (Book); People: EDWARDS, A. W. F.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
T1  - THE LOGICAL STATUS OF SUPPRESSOR VARIABLES.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1973///Fall73
VL  - 37
IS  - 3
M3  - Article
SP  - 359
EP  - 372
PB  - Oxford University Press / USA
SN  - 0033362X
AB  - While social scientists are aware that the relationship between an independent and dependent variable may be spurious, they are much less aware that the absence of relationship may be equally spurious. The chief reason is that the relationship is concealed by a suppressor test factor. This paper supplements earlier discussions of this topic by considering the logical status of suppressor test factors and compensating influences. Examples of antecedent, intervening, and component suppressor variables and of compensating influences are provided. It shows that, in a causal sense, standard test factors and suppressor test factors generate opposite interpretations of spuriousness, but in a formal sense they are the same. Several substantive contributions of suppressor variables to  social science are discussed.  Suppressor variables are not rarities, but may actually appear as often as  standard test factors in research. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Interpersonal relations
KW  - Social scientists
KW  - Points of contact (Conflict of laws)
KW  - Social sciences
KW  - Variables (Mathematics)
KW  - Social factors
N1  - Accession Number: 5413691; Rosenberg, Morris 1,2; Affiliations: 1: Research Sociologist, National Institute of Mental Health; 2: Adjunct Professor, The American University; Issue Info: Fall73, Vol. 37 Issue 3, p359; Thesaurus Term: Interpersonal relations; Subject Term: Social scientists; Subject Term: Points of contact (Conflict of laws); Subject Term: Social sciences; Subject Term: Variables (Mathematics); Subject Term: Social factors; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 14p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 2013-20922-008
AN  - 2013-20922-008
AU  - Stierlin, Helm
T1  - The adolescent as delegate of his parents.
JF  - Australian and New Zealand Journal of Psychiatry
JO  - Australian and New Zealand Journal of Psychiatry
JA  - Aust N Z J Psychiatry
Y1  - 1973/09//
VL  - 7
IS  - 3
SP  - 249
EP  - 256
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0004-8674
SN  - 1440-1614
AD  - Stierlin, Helm, Family Studies Section, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-20922-008. Partial author list: First Author & Affiliation: Stierlin, Helm; Family Studies Section, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Informa Healthcare; Sage Publications. Release Date: 20131028. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Parents; Separation Reactions. Minor Descriptor: Loyalty; Offspring. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 8. Issue Publication Date: Sep, 1973. 
AB  - The concept of the adolescent as a delegate of his parents illuminates many vicissitudes of the separation process between parents and their adolescent offspring, and also introduces differing treatment perspectives. Where an adolescent is delegated, he is encouraged and allowed to move out of the parental orbit—up to a point! He is then held on a long leash, as it were, and his separation is made limited and conditional. Such qualified 'sending out' is implied in the original Latin word 'delegate', which means, first, to send out and, second, to entrust with a mission. The latter meaning implies that the delegate—although sent out—remains beholden to the person who sends him out. This becomes possible only on the basis of a strong, though often invisible and selective, loyalty. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adolescent offspring
KW  - delegate
KW  - vicissitudes
KW  - separation process
KW  - treatment perspectives
KW  - loyalty
KW  - parents
KW  - 1973
KW  - Adolescent Attitudes
KW  - Parents
KW  - Separation Reactions
KW  - Loyalty
KW  - Offspring
KW  - 1973
DO  - 10.3109/00048677309159757
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - OFFICER, J. EARLE
AU  - TECSON, NORA
AU  - ESTES, JOHN D.
AU  - FONTANILLA, EVELYN
AU  - RONGEY, ROBERT W.
AU  - GARDNER, MURRAY B.
T1  - Isolation of a Neurotropic Type C Virus.
JO  - Science
JF  - Science
Y1  - 1973/09/07/
VL  - 181
IS  - 4103
M3  - Article
SP  - 945
EP  - 947
SN  - 00368075
AB  - A neurogenic paralysis of the lower limb can be induced and serially transmitted in mice by a nontransforming type C viruts strain that originated in an embryo of a wild mouse. The virus exerted a neurotropic effect on the anterior horn neurons. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117261; OFFICER, J. EARLE 1; TECSON, NORA 1; ESTES, JOHN D. 2; FONTANILLA, EVELYN 3; RONGEY, ROBERT W. 3; GARDNER, MURRAY B. 3; Affiliations: 1: Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033; 2: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Departmnent of Pathology, University of Southern California School of Medicine; Issue Info: 9/ 7/1973, Vol. 181 Issue 4103, p945; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SMITH JR., J. CECIL
AU  - MCDANIEL, E. G.
AU  - FAN, F. F.
AU  - HALSTED, JAMES A.
T1  - Zinc: A Trace Element Essential in Vitamin A Metabolism.
JO  - Science
JF  - Science
Y1  - 1973/09/07/
VL  - 181
IS  - 4103
M3  - Article
SP  - 954
EP  - 955
SN  - 00368075
N1  - Accession Number: 85117266; SMITH JR., J. CECIL 1; MCDANIEL, E. G. 1; FAN, F. F. 1; HALSTED, JAMES A. 1; Affiliations: 1: Veterans Administration Hospital, Washington, D.C. 20422, and National Institutes of Health, Bethesda, Maryland 20014, and School of Medicine, George Washington University, Washington, D.C. 20005; Issue Info: 9/ 7/1973, Vol. 181 Issue 4103, p954; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BENNETT, H. STANLEY
AU  - ALBRO, PHILLIP W.
T1  - PCB's in Microscope Immersion Oil.
JO  - Science
JF  - Science
Y1  - 1973/09/14/
VL  - 181
IS  - 4104
M3  - Article
SP  - 990
EP  - 990
SN  - 00368075
N1  - Accession Number: 85117271; BENNETT, H. STANLEY 1; ALBRO, PHILLIP W. 2; Affiliations: 1: Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill 27514; 2: Analytical and Synthetic Chemistry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 9/14/1973, Vol. 181 Issue 4104, p990; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pommier, Jacques
AU  - Sokoloff, Louis
AU  - Nunez, Jacques
T1  - Enzymatic Iodination of Protein.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1973/09/15/
VL  - 38
IS  - 3
M3  - Article
SP  - 497
EP  - 506
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The initial rate of I2 formation catalyzed by horse-radish peroxidase exhibited a clear sigmoid relationship with respect to the concentration of I--. These data were found to fit an equa- tion based on a model which predicts a second-order dependence on iodide concentration and are consistent with a bimolecular reaction between two I- ions on the surface of the enzyme. Such a model presumes two sites for the substrate on the enzyme. The initial rate of lysozyme iodination also exhibited a clear sigmoid relationship with respect to concentration of I-. The sigmoidicity increased with the lysozyme concentration. These experimental data fit a random-ordered sequence of substrate fixation but with one of the two possible sequences kinetically preferred. These results also suggest that lysozyme interacts with the enzyme and that there are two sites for substrate addition on the surface of the enzyme. When the ratio of the concentrations of both substrates, iodide and lysozyme, is varied, the rates of formation of each product, I2 or iodinated protein, also vary; the lower the iodide/protein ratio, the lower the I2 yield and the higher the rate of protein iodination. Studies on the influence of pH on the nature of the product showed that I2 formation is favored at acidic pH and protein iodination at more alkaline pH. These results are also consistent with a two-site model for the enzyme, both sites being able to fix either two iodide ions or one iodide ion and one lysozyme molecule. The affinity of the sites for each one of the two substrates differs according to the pH. This conclusion was confirmed by the observation that iodination of free tyrosine could be obtain- ed with very good yields provided that the pH of the reaction was adjusted to avoid either com- plete dimerization of free tyrosine, which is favored at alkaline pH, or I2 formation which is favor- ed at low pH. These results and other quantitative data on the stoiehiometry of H2O2 consumption do not establish unequivocally which is the oxidized iodide-reacting species, I+ or Io. However, they indicate that I2 is not the iodinating species in the protein iodination reaction catalyzed by horse- radish peroxidase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEROXIDASE
KW  - LYSOZYMES
KW  - PHENOL oxidase
KW  - ENZYMOLOGY
KW  - ANIMAL models in research
KW  - BIOCHEMISTRY
N1  - Accession Number: 13660720; Pommier, Jacques 1 Sokoloff, Louis 1 Nunez, Jacques 1; Affiliation:  1: Unité de Recherche sur la Glande Thyroïde et la Régulation Hormonale de l'Institut National de la Santé et de la Recherche Médicale, Bicêtre, and Section on Developmental Neurochemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland; Source Info: 1973, Vol. 38 Issue 3, p497; Subject Term: PEROXIDASE; Subject Term: LYSOZYMES; Subject Term: PHENOL oxidase; Subject Term: ENZYMOLOGY; Subject Term: ANIMAL models in research; Subject Term: BIOCHEMISTRY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SINGER, MAXINE
AU  - SOLL, DIETER
T1  - Guidelines for DNA Hybrid Molecules.
JO  - Science
JF  - Science
Y1  - 1973/09/21/
VL  - 181
IS  - 4105
M3  - Article
SP  - 1125
EP  - 1125
SN  - 00368075
N1  - Accession Number: 85117318; SINGER, MAXINE 1; SOLL, DIETER 2; Affiliations: 1: Room 9N-119, Building 10, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520; Issue Info: 9/21/1973, Vol. 181 Issue 4105, preceding p1125; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KEEPER, LARRY K.
AU  - ROLLER, PETER P.
T1  - N-Nitrosation by Nitrite Ion in Neutral and Basic Medium.
JO  - Science
JF  - Science
Y1  - 1973/09/28/
VL  - 181
IS  - 4106
M3  - Article
SP  - 1245
EP  - 1247
SN  - 00368075
AB  - Formaldehyde catalyzed the conversion of various secondary amines to nitrosamines in the pH range 6.4 to 11.0. Chloral was also an eflective catalyst. The reaction proceeds easily enough to have potential synthetic applications; the proposed mechanism could explain sonme reported anomalies regarding the synthesis of carcinogenic N-nitroso compounds in vivo and in vitro. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117366; KEEPER, LARRY K. 1; ROLLER, PETER P. 1; Affiliations: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/28/1973, Vol. 181 Issue 4106, p1245; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Duttera, M. J.;
AU  - Bleyer, W. A.;
AU  - Pomeroy, T. C.;
AU  - Leventhal, C. M.;
AU  - Leventhal, B. G.;
T1  - Irradiation, methotrexate toxicity, and the treatment of meningeal leukemia
CT  - Irradiation, methotrexate toxicity, and the treatment of meningeal leukemia
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1973/09/29/
VL  - 2
IS  - Sep 29
SP  - 703
EP  - 707
SN  - 00237507
AD  - Pediatric Oncology Branch and Radiation Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-2049; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 23; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - Thirty-one patients with meningeal leukemia were randomized to therapy with intrathecal methotrexate (I) with and without 2400r to the cranial vault. Induction therapy was given with I at 15 mg./sq.m. every 2-3 days until abnormal cells disappeared from the cerebrospinal fluid to a maximum of 8 doses. If CNS remission was not obtained at this point treatment was considered to have failed. Once abnormal cells had disappeared from the spinal fluid, a consolidation period of 6 weekly doses was given followed by monthly maintenance injections. If patients showed severe toxic reactions they were treated instead for consolidation or maintenance with cytosine arabinoside 30 mg./sq.m./dose on the same schedule. Remissions were achieved in 29 patients. Remission duration was significantly longer (234+ days) in the group receiving I alone than in those receiving I and irradiation (125 days). A spectrum of I toxicity was seen after intrathecal administration ranging in severity from chemical arachnoiditis which was common (17 patients) through transient paresis (1 patient) to encephalopathy (2 patients). These toxicities were just as common in patients receiving preservative-free I as in those receiving I with preservative, and therefore should be ascribed to direct toxic effects of I itself or its breakdown products rather than preservative. The neurotoxicity of I must be taken into account in evaluating the risks and benefits of the therapy for meningeal leukemia.
KW  - Methotrexate--alone and with radiation-;
KW  - Antineoplastic agents--methotrexate--alone and with radiation, leukemia, meningeal, therapy, in patient;
KW  - Toxicity--methotrexate--side effects, during therapy for meningeal leukemia, in patient;
KW  - Preservatives--methotrexate--toxicity, lack, intrathecal, in patients;
KW  - Toxicity--preservatives--lack, methotrexate intrathecal, in patients;
KW  - Radiation--and methotrexate--leukemias, meningeal, therapy, in patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Falk, Stephen A.
T1  - Letter: Environmental noise.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/10//
VL  - 63
IS  - 10
M3  - Letter
SP  - 833
EP  - 836
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "The Non-Auditory Effects of Environmental Noise," by Karl Kryter in the March 1972 issue.
KW  - Noise pollution
KW  - Letters to the editor
N1  - Accession Number: 19876927; Falk, Stephen A. 1; Affiliations: 1: Biophysics & Instrumentation Section, Research Services Branch, National Institute of Environmental Health Sciences, P.O. Box 12233; Issue Info: Oct1973, Vol. 63 Issue 10, p833; Thesaurus Term: Noise pollution; Subject Term: Letters to the editor; Number of Pages: 4p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Eyres, Sandra J.
T1  - Public Health Nursing Section Report of the 1972 APHA Smoking Survey.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1973/10//
VL  - 63
IS  - 10
M3  - Article
SP  - 846
EP  - 852
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents a survey which identifies the smoking behavior of American Public Health Association (APHA) members in the U.S. The association conducted the survey in order to determine how they could best contribute to the goal of decreasing cigarette smoking within the country. It has shown additional evidence that health professionals' own smoking behavior is related to their attitudes and actions in urging a change in the smoking behavior of those to whom they give care. In addition, the said survey presented the percentage of APHA members who ever tried to persuade someone to stop smoking.
KW  - Smoking
KW  - Cigarette smokers
KW  - Public health
KW  - Health surveys
KW  - Associations, institutions, etc. -- Membership
KW  - Medical care
KW  - Medical personnel
KW  - United States
KW  - American Public Health Association (APHA)
KW  - Smoking survey
KW  - American Public Health Association
N1  - Accession Number: 7971063; Eyres, Sandra J. 1; Affiliations: 1: Nurse Consultant, Division of Nursing, National Institutes of Health, Bethesda, Maryland; Issue Info: Oct1973, Vol. 63 Issue 10, p846; Thesaurus Term: Smoking; Thesaurus Term: Cigarette smokers; Thesaurus Term: Public health; Subject Term: Health surveys; Subject Term: Associations, institutions, etc. -- Membership; Subject Term: Medical care; Subject Term: Medical personnel; Subject: United States; Author-Supplied Keyword: American Public Health Association (APHA); Author-Supplied Keyword: Smoking survey ; Company/Entity: American Public Health Association; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P.;
AU  - Kahn, R.;
AU  - Gorden, P.;
AU  - Wells, S.;
AU  - DeVita, V. T.;
T1  - Streptozotocin for malignant insulinomas and carcinoid tumor
CT  - Streptozotocin for malignant insulinomas and carcinoid tumor
JO  - Archives of Internal Medicine (USA)
JF  - Archives of Internal Medicine (USA)
Y1  - 1973/10/01/
VL  - 132
IS  - Oct
SP  - 555
EP  - 561
SN  - 00039926
AD  - National Institutes of Health, Medicine Branch, NC1, Bethesda, Maryland 20014
N1  - Accession Number: 11-2411; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin; References: 30; Journal Coden: AIMDAP; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Four patients with metastatic insulinoma were treated with streptozotocin, with one complete remission lasting one year. The patient received 4 g.; major bone marrow depression was seen. Serum half life was 15 minutes.
KW  - Streptozotocin--effects-;
KW  - Antineoplastic agents--streptozotocin--effects, metastatic insulinoma, in patients;
KW  - Toxicity--streptozotocin--side effects, bone marrow depression, in patients;
KW  - Half-life--streptozotocin--blood levels, metastatic insulinoma therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lee, Douglas H. K.
T1  - Specific Approaches to Health Effects of Pollutants.
JO  - Bulletin of the Atomic Scientists
JF  - Bulletin of the Atomic Scientists
Y1  - 1973/10//
VL  - 29
IS  - 8
M3  - Article
SP  - 45
EP  - 47
PB  - Bulletin of the Atomic Scientists
SN  - 00963402
N1  - Accession Number: 21583355; Lee, Douglas H. K. 1; Affiliation:  1: Associate Director, National Institute of Environmental Health Sciences; Source Info: Oct1973, Vol. 29 Issue 8, p45; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Buja, L. J.;
AU  - Ferrans, V. J.;
AU  - Mayer, R. J.;
AU  - Roberts, W. C.;
AU  - Henderson, E. S.;
T1  - Cardiac ultrastructural changes induced by daunorubicin therapy
CT  - Cardiac ultrastructural changes induced by daunorubicin therapy
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1973/10/01/
VL  - 32
IS  - Oct
SP  - 771
EP  - 788
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 11-2023; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 65; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: Linda K. McCoy
N2  - Histologic and ultrastructural studies were made of the hearts of 6 patients with acute leukemias to elucidate the mechanisms of the cardiotoxicity induced by daunorubicin (daunomycin). Three patients had received relatively high doses (455, 460, and 500 mg./sq. m.); one a relatively low total dose (120 mg./sq.m.); 2 patients who had not been treated with this drug served as controls. Histologic changes observed only in the hearts of the 3 patients with relatively high doses consisted of scattered foci of damaged, degenerating, and atrophic muscle cells. These changes were more widespread in the patient who had received the highest dose and developed clinical signs of cardiotoxicity. Alterations of chromatin were observed in 10% of nuclei of cardiac muscle cells in the 3 patients treated with relatively high doses of daunomycin. These changes consisted of a transformation of variable amounts of chromatin into thick fibers, intermediate-sized fibers, and thin filaments. These alterations were interpreted as representing various stages of uncoiling and unraveling of chromatin and were considered to be related to the phenomenon of intercalation of daunomycin into DNA. Cardiotoxicity may be related to the inability of non-dividing cardiac muscle cells to repair daunomycin-induced alterations in DNA.
KW  - Daunomycin--toxicity-;
KW  - Antineoplastic agents--daunomycin--toxicity, studies, cardiac, in patients;
KW  - Toxicity--daunomycin--studies, cardiac, in patients;
KW  - Dosage--daunomycin--toxicity, studies, cardiac, correlations, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cohen, M. H.;
T1  - Enhancement of the antitumor effect of 1,3-bis (2-chloroethyl) 1-nitrosourea by chlorpromazine and caffeine
CT  - Enhancement of the antitumor effect of 1,3-bis (2-chloroethyl) 1-nitrosourea by chlorpromazine and caffeine
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1973/10/01/
VL  - 51
IS  - Oct
SP  - 1323
EP  - 1325
SN  - 00278874
AD  - NCI-VA Medical Oncology Branch, National Cancer Institute, Veterans Administration Hospital, 50 Irving Street N.W., Washington, D. C.
N1  - Accession Number: 11-1842; Language: English; Trade Name: BCNU; Generic Name: Carmustine; Chemical Name: Chlorpromazine--50-53-3 Carmustine--154-93-8 Caffeine--58-08-2; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine, caffeine and carmustine (28:20); AHFS Class: Central nervous system stimulants caffeine, carmustine and chlorpromazine (10:00); AHFS Class: Antineoplastic agents carmustine, caffeine and chlorpromazine; References: 13; Section Heading: Drug Evaluations
N2  - A study of combined therapy with chlorpromazine, BCNU (carmustine), and caffeine, showed markedly increased survival of murine L1210 leukemic mice over treatment with BCNU alone. All 3 drugs had to be given together, because neither chlorpromazine plus BCNU nor BCNU plus caffeine treatment improved survival relative to an appropriate control group. The optimal time for chlorpromazine treatment was 6 hours before BCNU. Prior exposure to caffeine of both recipient mice and L1210 cells used for transplantation did not affect therapeutic response. The mechanism of enhancement of BCNU by chlorpromazine and caffeine is unknown.
KW  - Chlorpromazine--caffeine and carmustine-;
KW  - Carmustine--caffeine and chlorpromazine-;
KW  - Caffeine--carmustine and chlorpromazine-;
KW  - Combined therapy--carmustine, caffeine, and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW  - Combined therapy--caffeine, carmustine, and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW  - Combined therapy--chlorpromazine, caffeine, and carmustine--leukemias, therapy, improved over carmustine alone, in mice;
KW  - Tranquilizers--chlorpromazine, caffeine and carmustine--leukemias, therapy, improved over carmustine alone, in mice;
KW  - Central nervous system stimulants--caffeine, carmustine and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW  - Antineoplastic agents--carmustine, caffeine and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW  - Dosage schedules--chlorpromazine, caffeine and carmustine--pretreatment, with chlorpromazine, therapy, in leukemic mice;
KW  - Dosage schedules--carmustine, chlorpromazine and caffeine--pretreatment, with chlorpromazine, therapy, in leukemic mice;
KW  - Drug interactions--carmustine, chlorpromazine and caffeine--potentiation, effects, over carmustine alone, in leukemic mice;
KW  - Drug interactions--caffeine, carmustine and chlorpromazine--potentiation, effects, over carmustine alone, in leukemic mice;
KW  - Drug interactions--chlorpromazine, caffeine and carmustine--potentiation, effects, over carmustine alone, in leukemic mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chirigos, M. A.;
AU  - Pearson, J. W.;
T1  - Cure of murine leukemia with drug and interferon treatment
CT  - Cure of murine leukemia with drug and interferon treatment
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1973/10/01/
VL  - 51
IS  - Oct
SP  - 1367
EP  - 1368
SN  - 00278874
AD  - Viral Leukemia and Lymphoma Branch, National Cancer Institute, NIH, Public Health Service, U. S. Department of Health Education and Welfare, Bethesda, Maryland
N1  - Accession Number: 11-1474; Language: English; Chemical Name: Interferon--9008-11-1; References: 13; Section Heading: Drug Interactions; Pharmacology
N2  - A discussion of the effects of interferon and drug therapy in the treatment of leukemia is presented. Interferon has limited in vivo antitumor activity when host tumor load is great. When systemic leukemia is arrested by drug therapy which leads to a reduction of tumor cells, subsequent treatment with interferon leads to a significant number of cures. The combined drug and interferon treatment exerts a synergistic antitumor effect.
KW  - Interferon--interactions-;
KW  - Antineoplastic agents--interactions--interferon, synergism, leukemia therapy;
KW  - Drug interactions--interferon and antineoplastic agents--synergism, leukemia therapy;
KW  - Drug interactions--antineoplastic agents and interferon--synergism, leukemia therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Pavalko, Ronald M.
AU  - Lutterman, Kenneth G.
T1  - CHARACTERISTICS OF WILLING AND RELUCTANT RESPONDENTS.
JO  - Pacific Sociological Review
JF  - Pacific Sociological Review
Y1  - 1973/10//
VL  - 16
IS  - 4
M3  - Article
SP  - 463
EP  - 476
SN  - 00308919
AB  - The effects of education, socioeconomic status, and I.Q. on responses to a mail questionnaire.
KW  - PUBLIC opinion polls
KW  - DIRECT marketing
KW  - POPULATION
KW  - PROBABILITY theory
KW  - LONGITUDINAL method
KW  - SOCIAL classes
KW  - SOCIAL surveys
KW  - QUESTIONNAIRES
KW  - Respondents
N1  - Accession Number: 15506063; Pavalko, Ronald M. 1; Lutterman, Kenneth G. 2; Affiliations: 1 : Florida State University.; 2 : National Institute of Mental Health.;  Source Info: Oct1973, Vol. 16 Issue 4, p463; Historical Period: 1957 to 1965; Subject Term: PUBLIC opinion polls; Subject Term: DIRECT marketing; Subject Term: POPULATION; Subject Term: PROBABILITY theory; Subject Term: LONGITUDINAL method; Subject Term: SOCIAL classes; Subject Term: SOCIAL surveys; Subject Term: QUESTIONNAIRES; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
ID  - 2006-06243-030
AN  - 2006-06243-030
AU  - Waskow, Irene E.
AU  - Katz, Martin M.
T1  - Exploring Subjective Responses.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1973/10//
VL  - 18
IS  - 10
SP  - 486
EP  - 488
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06243-030. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Waskow, Irene E.; National Institute of Mental Health, Section on Psychotherapy and Behavioral Intervention, Clinical Research Branch, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Marijuana; Toxicity. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Tart, Charles T. On Being Stoned=Palo Alto: Science and Behavior Books, 1971. Pp. xvii + 333. $7.95; 1971. Page Count: 3. Issue Publication Date: Oct, 1973. 
AB  - Reviews the book, On Being Stoned by Charles T. Tart (see record [rid]1972-08365-000[/rid]). The purpose of the study described in this book was, according to Tart, to get an overall look at marijuana intoxication as it occurs in the ordinary world, to get an idea of the range of possible effects, the frequency of their occurrence, and the intoxication levels at which they occur. In summary, this book is a detailed report of the results of a fairly interesting and useful study, if taken for what it is--an exploratory study of subjective responses to marijuana of a fairly selective population. In general, we viewed this study as a useful effort, but with fairly limited scientific and theoretical implications for the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - marijuana intoxication
KW  - subjective responses
KW  - 1973
KW  - Drug Abuse
KW  - Marijuana
KW  - Toxicity
KW  - 1973
U2  - Tart, Charles T. (1971); On Being Stoned; Palo Alto: Science and Behavior Books, 1971. Pp. xvii + 333. $7.95
DO  - 10.1037/0011676
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41581-002
AN  - 2013-41581-002
AU  - Brown, Bertram S.
T1  - A national view of mental health.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1973/10//
VL  - 43
IS  - 5
SP  - 700
EP  - 705
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41581-002. PMID: 4355122 Partial author list: First Author & Affiliation: Brown, Bertram S.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1973, New York, NY, US. Conference Note: This article was presented at the aforementioned conference. Major Descriptor: Community Mental Health Centers; Orthopsychiatry; Scientific Communication. Minor Descriptor: Professional Organizations; Clinical Models. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 6. Issue Publication Date: Oct, 1973. 
AB  - This article provides an overview of the Presidential Session of the 1973 annual meeting of the American Orthopsychiatric Association, held in New York. The theme of the Session was to provide a national view of mental health. If the definition of mental health includes racism, poverty, and violence then one deals with a different quantitative and qualitative set of issues than if one limits the mental health domain to serious overt mental illness. The assignment of providing a national perspective on mental health is so complex that the author uses a limited model, drawn from oversimplified biology-fully realizing that Ortho is not the place to overdraw medical models and medical analogies. One way to begin to gauge the nation's mental health is to take the pulse, or count the beats. Clearly, the federal direction at the moment is away from Washington, to ward the local community. The Administration has recommended that there be no more federal support of Community Mental Health Centers, but rather that we encourage local support. The author's view of mental health cannot be definitive or conclusive, but it is optimistic. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - American Orthopsychiatric Association
KW  - medical models
KW  - community mental health centers
KW  - 1973
KW  - Community Mental Health Centers
KW  - Orthopsychiatry
KW  - Scientific Communication
KW  - Professional Organizations
KW  - Clinical Models
KW  - 1973
DO  - 10.1111/j.1939-0025.1973.tb00840.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - May, J. E.;
AU  - Rosse, W.;
AU  - Frank, M. M.;
T1  - Paroxysmal nocturnal hemoglobinuria: alternate complement pathway mediated lysis induced by magnesium
CT  - Paroxysmal nocturnal hemoglobinuria: alternate complement pathway mediated lysis induced by magnesium
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1973/10/04/
VL  - 289
IS  - Oct 4
SP  - 705
EP  - 709
SN  - 00284793
AD  - National Institutes of Health, Building 10, Room 11N-104, LCI, NIAID, Bethesda, Maryland 20014
N1  - Accession Number: 11-2098; Language: English; Chemical Name: Magnesium--7439-95-4 Calcium--7440-70-2; Therapeutic Class: (40:12); AHFS Class: Electrolytes magnesium (40:12); AHFS Class: Electrolytes calcium; References: 20; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - The central role of the magnesium ion in the lysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria by normal serum was demonstrated in this study. This lysis was examined as a function of calcium and magnesium ion concentration in 8 patients and 8 normal donors. The addition of as little as 3 X 10\SU/\-/4\BS/ molar magnesium (0.6 meq./l.) to normal human serum initiated lysis of cells from patients with the disorder, via the alternate pathway of complement activation, and markedly potentiated the lysis of these cells in acidified serum by the same pathway. This finding led to a simple modification of the acidified serum lysis test (Ham test), which renders it more accurate in the diagnosis of paroxysmal nocturnal hemoglobinuria and more precise in delineation of the abnormal erythrocyte populations. Also demonstrated is the fact that calcium ion inhibits lysis of the abnormal cells in acidified and nonacidified human serum. Small changes in the concentration of these cations may result in spontaneous activation of the alternate complement pathway, thereby precipitating hemolytic attacks.
KW  - Magnesium--ions-;
KW  - Calcium--ions-;
KW  - Electrolytes--magnesium--ions, effects on erythrocyte lysis, from patients with paroxysmal nocturnal hemoglobinuria, in vitro;
KW  - Electrolytes--calcium--ions, effects on erythrocyte lysis, from patients with paroxysmal nocturnal hemoglobinuria, in vitro;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - LIEBER, M. M.
AU  - BENVENISTE, R. E.
AU  - LIVINGSTON, D. M.
AU  - TODARO, G. J.
T1  - Mammalan Cells in Culture Frequently Release Type C Viruses.
JO  - Science
JF  - Science
Y1  - 1973/10/05/
VL  - 182
IS  - 4107
M3  - Article
SP  - 56
EP  - 59
SN  - 00368075
AB  - Cell cultures commonly used in animal cell research, both cell strains andcontinuous cell lines from various mammalian species, spontaneously produce type C RNA viruses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117397; LIEBER, M. M. 1; BENVENISTE, R. E. 1; LIVINGSTON, D. M. 1; TODARO, G. J. 1; Affiliations: 1: Viral Leukemia and Lymphoina Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/ 5/1973, Vol. 182 Issue 4107, p56; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bleyer, W. A.;
AU  - Drake, J. C.;
AU  - Chabner, B. A.;
T1  - Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia
CT  - Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1973/10/11/
VL  - 289
IS  - Oct 11
SP  - 770
EP  - 773
SN  - 00284793
AD  - Building 10, Room 6N119, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-1232; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 16; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Joan Lentine
N2  - This report describes the pharmacokinetics of methotrexate disappearance from the cerebrospinal fluid after intrathecal therapy or prophylaxis in 25 patients with acute leukemia, and presents evidence relating neurotoxic reactions in 5 patients to elevated levels of methotrexate concentrations in the cerebrospinal fluid. All patients received preservative free methotrexate at 12 or 15 mg./sq. m./dose. The drug was administered twice weekly until the cerebrospinal fluid leukemic cells disappeared, or for 5 doses in patients treated prophylactically. The drug was injected at a concentration of 1 mg./ml. and in a volume of 12 to 15 ml./sq. m., after isovolumetric removal of cerebrospinal fluid. Methotrexate concentration was determined by the dihydrofolate reductase inhibition method, with use of enzyme derived from L1210 leukemic cells resistant to methotrexate. In 20 patients with no manifestations of neurotoxicity, the mean antifolate value in the cerebrospinal fluid was 1.7 \X/ 10\SU/\-/7\BS/M two days after administration of 12 to 15 mg./sq. m., and declined thereafter with a half-life of 12 to 18 hours. Five patients with severe neurotoxicity had cerebrospinal fluid methotrexate concentrations averaging 13.8 times higher than the mean, and these concentrations were consistently higher than the range of antifolate values in the asymptomatic patients. One patient with values 20 to 100 times greater than the mean in asymptomatic patients sustained a fatal myelopathy, and in another, with an apparent antifolate half-life of 48 hours, irreversible neurologic sequelae developed. These observations suggest that the neurotoxicity associated with intrathecal methotrexate may be secondary to prolonged exposure to excessive drug concentrations in the central nervous system.
KW  - Methotrexate--pharmacokinetics-;
KW  - Pharmacokinetics--methotrexate--cerebrospinal fluid, of leukemia patients;
KW  - Antineoplastic agents--methotrexate--pharmacokinetics, in cerebrospinal fluid of leukemia patients;
KW  - Toxicity--methotrexate--neuro-, relation to elevated cerebrospinal fluid levels, of leukemia patients;
KW  - Metabolism--methotrexate--pharmacokinetics, cerebrospinal fluid, of leukemia patients;
KW  - Drugs, body distribution--methotrexate--pharmacokinetics, cerebrospinal fluid, of leukemia patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - JACOBS, LEON
T1  - NIH Grants and Contracts.
JO  - Science
JF  - Science
Y1  - 1973/10/12/
VL  - 182
IS  - 4108
M3  - Article
SP  - 113
EP  - 113
SN  - 00368075
N1  - Accession Number: 85117416; JACOBS, LEON 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/12/1973, Vol. 182 Issue 4108, p113; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MILLER, EPP A.
AU  - GOLDMAN, PATRICIA S.
AU  - ROSVOLD, H. ENGER
T1  - Delayed Recovery of Function following Orbital Prefontal Lesions in Infant Monkeys.
JO  - Science
JF  - Science
Y1  - 1973/10/19/
VL  - 182
IS  - 4109
M3  - Article
SP  - 304
EP  - 306
SN  - 00368075
AB  - Monkeys given orbital prefrontal lesions at 1, 4, or 8 weeks of age exhibited a severe learning disability when they were tested at 1 year of age, but showed substantial recovery by the time they were 2 years old. These results Suggest that the protracted maturation of intact cortical regions is important in recovery of function after early brain injury. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117491; MILLER, EPP A. 1; GOLDMAN, PATRICIA S. 1; ROSVOLD, H. ENGER 1; Affiliations: 1: Section on Neuropsychology, Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 10/19/1973, Vol. 182 Issue 4109, p304; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kattwinkel, J.;
AU  - Taussig, L. M.;
AU  - McIntosh, C. L.;
AU  - di Sant'Agnese, P. A.;
AU  - Boat, T. F.;
AU  - \ET/;
T1  - Intrapleural instillation of quinacrine for recurrent pneumothorax. Use in a patient with cystic fibrosis
CT  - Intrapleural instillation of quinacrine for recurrent pneumothorax. Use in a patient with cystic fibrosis
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1973/10/29/
VL  - 226
IS  - Oct 29
SP  - 557
EP  - 559
AD  - Building 10, Room 8N-250, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-3016; Language: English; Chemical Name: Quinacrine--83-89-6; References: 12; Publication Type: Brief Reports; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Intrapleural instillation of quinacrine HCl was used to treat recurrent bilateral pneumothorax in a 29-year-old man with advanced pulmonary disease from cystic fibrosis. For 23 months and 11 months following intrapleural instillation of quinacrine into the left and right lungs, respectively, there was no recurrence of pneumothorax on either side. Death was due to pulmonary failure, and at autopsy there were dense adhesions completely obliterating the pleural spaces. This mode of therapy may provide a valuable alternative to surgery for the cystic fibrosis patient with severe lung disease and marginal pulmonary reserve.
KW  - Quinacrine--pneumothorax-;
KW  - Pneumothorax--quinacrine--therapy, by intrapleural instillation, in cystic fibrosis patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kleinman, L. M.;
AU  - Tangrea, J. A.;
AU  - Gallelli, J. F.;
AU  - Brown, J. H.;
AU  - Gross, E.;
T1  - Stability of solutions of essential amino acids
CT  - Stability of solutions of essential amino acids
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1973/11/01/
VL  - 30
IS  - Nov
SP  - 1054
EP  - 1057
SN  - 00029289
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-0252; Language: English; Chemical Name: Sodium bisulfite--7631-90-5 Tryptophan--73-22-3; References: 5; Publication Type: Assay and Quality Control; Journal Coden: AJHPA9; Section Heading: Pharmaceutics; Drug Analysis
N2  - A study was conducted to develop a stable solution of essential amino acids for parenteral nutrition. The procedure of mixing the amino acids to attain most rapid dissolution is presented. Chromatographic analysis of the original solution stored in clear glass vials showed tryptophan to be the only amino acid to decrease in quantity (10% degradation at both 25\DG/ C. at 6 months storage and 50\DG/ C. at 2 months storage). The addition of sodium bisulfite (0.1%) as an antioxidant caused a 25% decrease in tryptophan concentration in 4 hours at 25\DG/ C. Further chromatographic studies showed that sodium bisulfite reacts with tryptophan. Commercial amino acid solutions containing sodium bisulfite were also shown to have tryptophan degradation. Storage of the amino acid solution in amber vials resulted in a tryptophan concentration of 96% of original concentration after 6 months of storage at room temperature. It is recommended that solutions of essential amino acids be stored in amber vials at room temperature without sodium bisulfite with a 6-month expiration date.
KW  - Sodium bisulfite--incompatibilities-;
KW  - Tryptophan--incompatibilities-;
KW  - Amino acids--stability--solutions, effects of mixing, storage and antioxidants;
KW  - Stability--amino acids--solutions, effects of mixing, storage and antioxidants;
KW  - Incompatibilities--sodium bisulfite and tryptophan--degradation, in amino acid solutions;
KW  - Incompatibilities--tryptophan and sodium bisulfite--degradation, in amino acid solutions;
KW  - Antioxidants--sodium bisulfite--incompatibilities, tryptophan, degradation, in amino acid solutions;
KW  - Amino acids--tryptophan--incompatibilities, sodium bisulfite, degradation, in amino acid solutions;
KW  - Storage--amino acids--solutions, effects on stability;
KW  - Light--amino acids--solutions, effects on stability;
KW  - Stability--sodium bisulfite--incompatibilities, tryptophan, in amino acid solution;
KW  - Nutrition--amino acids--injections, amino acids, stability, effects of mixing, storage and antioxidants;
KW  - Caloric agents--amino acids--hyperalimentation, injections, stability, effects of mixing, storage and antioxidants;
KW  - Hyperalimentation--amino acids--injections, stability, effects of mixing, storage and antioxidants;
KW  - Injections--amino acids--hyperalimentation, stability, effects of mixing, storage and antioxidants;
KW  - Temperature--amino acids--solutions, effects on stability;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Balter, M. B.;
AU  - Cisin, I. H.;
AU  - Davidson, S. T.;
AU  - Manheimer, D. I.;
AU  - Mellinger, G. D.;
AU  - \ET/;
T1  - Popular attitudes and beliefs about tranquilizers
CT  - Popular attitudes and beliefs about tranquilizers
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1973/11/01/
VL  - 130
IS  - Nov
SP  - 1246
EP  - 1253
SN  - 0002953X
AD  - Box 5007, Berkeley, California 94715
AD  - Institute for Research in Social Behavior, Berkeley, California; and Special Studies Section, Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland
N1  - Accession Number: 11-3157; Language: English; References: 5; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: C. Robert Sturwold
N2  - In a nation-wide survey of the extent and nature of psychotherapeutic drug use, respondents were questioned about their knowledge of tranquilizers and their attitudes toward the use of these drugs in general and in specific situations. Questions were designed to assess attitudes and beliefs concerning the use of tranquilizers, their effectiveness, the morality of using tranquilizers, their impact on mood and behavior, and short- and long-term physical effects and risks associated with their use. The data presented were obtained in personal interviews with 2,552 persons from 18 to 74 years of age.
KW  - Psychotherapeutic agents--drug information--patients, use, attitudes, survey;
KW  - Tranquilizers--drug information--patients, use, attitudes, survey;
KW  - Drug information--psychotherapeutic agents--patients, use, attitudes, survey;
KW  - Drug information--tranquilizers--patients, use, attitudes, survey;
KW  - Patient information--psychotherapeutic agents--use, attitudes, survey;
KW  - Patient information--tranquilizers--use, attitudes, survey;
KW  - Rational therapy--psychotherapeutic agents--patients, use, attitudes, survey;
KW  - Rational therapy--tranquilizers--patients, use, attitudes, survey;
KW  - Sociology--psychotherapeutic agents--attitudes, survey of patients;
KW  - Statistics--psychotherapeutic agents--use, survey of patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Wyatt, R. J.;
AU  - Kaplan, J.;
AU  - Vaughan, T.;
T1  - Tolerance and dependence to serotonin
CT  - Tolerance and dependence to serotonin
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1973/11/01/
VL  - 29
IS  - Nov
SP  - 597
EP  - 599
AD  - Laboratory of Clinical Psychopharmacology, IRP National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, D.C. 20032
N1  - Accession Number: 12-0611; Language: English; Chemical Name: Carbidopa--38821-49-7; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents carbidopa and hydroxytryptophan (28:16); AHFS Class: Psychotherapeutic agents hydroxytryptophan and carbidopa; References: 19; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - In a trial of 11 phenothiazine-resistant chronic schizophrenic patients, 5-hydroxytryptophan (I) and carbidopa produced striking behavioral effects which were greatly diminished by gradual changes in I dosage. Dosage of I ranged up to 10 g./day while the dosage of carbidopa was maintained at 150 mg./day throughout the trial. It is speculated that tolerance and dependence developed to I administration in these patients and perhaps to serotonin itself. It is further speculated that rapid changes, even from normal serotonin concentration, might be responsible for many of the behavioral effects seen when the metabolism of serotonin is altered.
KW  - Hydroxytryptophan--and carbidopa-;
KW  - Carbidopa--and hydroxytryptophan-;
KW  - Combined therapy--hydroxytryptophan and carbidopa--dosage, and behavioral effects, in schizophrenic patients;
KW  - Combined therapy--carbidopa and hydroxytryptophan--dosage, and behavioral effects, in schizophrenic patients;
KW  - Dosage--hydroxytryptophan and carbidopa--effects, behavioral, in schizophrenic patients;
KW  - Dosage--carbidopa and hydroxytryptophan--effects, behavioral, in schizophrenic patients;
KW  - Psychotherapeutic agents--carbidopa and hydroxytryptophan--dosage, and behavioral effects, in schizophrenic patients;
KW  - Psychotherapeutic agents--hydroxytryptophan and carbidopa--dosage, and behavioral effects, in schizophrenic patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levis, W. R.;
AU  - Kraemer, K. H.;
AU  - Klingler, W. G.;
AU  - Peck, G. L.;
AU  - Terry, W. D.;
T1  - Topical immunotherapy of basal cell carcinomas with dinitrochlorobenzene
CT  - Topical immunotherapy of basal cell carcinomas with dinitrochlorobenzene
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1973/11/01/
VL  - 33
IS  - Nov
SP  - 3036
EP  - 3042
SN  - 00085472
AD  - Dermatology and Immunology Branches, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-2629; Language: English; Chemical Name: Dinitrochlorobenzene--25567-67-3 Croton oil--8001-28-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents dinitrochlorobenzene (84:00); AHFS Class: Topical preparations dinitrochlorobenzene (10:00); AHFS Class: Antineoplastic agents croton oil (84:00); AHFS Class: Topical preparations croton oil; References: 16; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - One hundred thirteen tumors in 5 dinitrochlorobenzene (I)-sensitized patients with multiple basal cell carcinomas were treated with topical I. Thirty-six of the 113, or 32%, showed complete clinical regression, for periods of 5 to 18 months. An additional 29% showed partial regression. I induced only 15 to 25% complete regression in 4 of the 5 patients, whereas 21 of 30 basal cell carcinomas treated with I underwent complete regression in the 5th patient. In addition to variation of patient response, there was variation of response of tumors on the same patient. Photographic data presented separately are of a 6th patient with uncountable confluent basal cell carcinomas who responded well to I, but in whom accurate quantification on an individual tumor basis was not possible. Controls in this study included 63 untreated tumors that were adjacent to and distant from treated tumors. These control tumors showed no evidence of regression. Eleven tumors treated with inert vehicles did not respond. One subject with over 100 nodular basal cell carcinomas became tolerant to I and failed to respond to high concentrations of the drug. Croton oil caused complete regression in 6 of 26 treated tumors. The mechanism of I-induced regression of basal cell carcinoma remains unknown. The disappearance of locally invasive human cancer following the therapeutic imposition of a controlled allergic contact dermatitis provides a useful model for the study of immunotherapy of cancer in humans.
KW  - Dinitrochlorobenzene--carcinomas-;
KW  - Croton oil--carcinomas-;
KW  - Antineoplastic agents--dinitrochlorobenzene--carcinomas, basal cell, topical therapy, in patients;
KW  - Topical preparations--dinitrochlorobenzene--carcinomas, basal cell, therapy, in patients;
KW  - Antineoplastic agents--croton oil--carcinomas, basal cell, topical therapy, in patients;
KW  - Topical preparations--croton oil--carcinomas, basal cell, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cohen, B. E.;
AU  - Cohen, I. K.;
T1  - Vitamin A: adjuvant and steroid antagonist in the immune response
CT  - Vitamin A: adjuvant and steroid antagonist in the immune response
JO  - J. Immunol.
JF  - J. Immunol.
Y1  - 1973/11/01/
VL  - 111
IS  - Nov
SP  - 1376
EP  - 1380
AD  - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland
N1  - Accession Number: 11-1705; Language: English; Chemical Name: Vitamin A--11103-57-4 Hydrocortisone--50-23-7; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- hydrocortisone; References: 17; Journal Coden: JOIMA3; Section Heading: Pharmacology
N2  - The effects of vitamin A and hydrocortisone on the immune response have been studied in the mouse. Vitamin A treatment alone markedly increases the normal number of antibody forming cells generated in the spleen in response to immunization with sheep red blood cells. The antibody response to immunization with dinitrophenylated ovalbumin, a haptenprotein conjugate, is also enhanced by vitamin A pretreatment. Furthermore, the immunosuppressive effect of hydrocortisone on the response to sheep red blood cells can be prevented by simultaneous administration of vitamin A.
KW  - Vitamin A--effects-;
KW  - Hydrocortisone--immunosuppression-;
KW  - Steroids, cortico---hydrocortisone--immunosuppression, prevention by simultaneous administration of vitamin A, in mice;
KW  - Drug interactions--hydrocortisone and vitamin A--inhibition, immunosuppression, in mice;
KW  - Drug interactions--vitamin A and hydrocortisone--inhibition, immunosuppression, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Yeh, S. Y.;
T1  - Separation and identification of morphine and its metabolites and congeners
CT  - Separation and identification of morphine and its metabolites and congeners
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1973/11/01/
VL  - 62
IS  - Nov
SP  - 1827
EP  - 1829
SN  - 00223549
AD  - Addiction Research Center, National Institute of Mental Health, Lexington, Kentucky 40507
N1  - Accession Number: 12-1962; Language: English; Chemical Name: Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 26; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2  - Morphine and its known and postulated metabolites and congeners, i.e., morphine N-oxide, normorphine, pseudomorphine, morphine-N-methyl iodide, codeine, norcodeine, morphine-3-glucuronide, and morphine ethereal sulfate, were separated by TLC and GLC.
KW  - Morphine--chromatography, gas-;
KW  - Chromatography, gas--morphine--and TLC, separation from metabolites and congeners;
KW  - Chromatography, thin layer--morphine--and chromatography, gas, separation from metabolites and congeners;
KW  - Analgesics and antipyretics--morphine--chromatography, gas, and TLC, separation from metabolites and congeners;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Williams Jr., Redford B.
AU  - Frankel, Bernard L.
AU  - Galin, J. Christian
AU  - Weiss, James L.
T1  - Cardiovascular Response During a Word Association Test and an Interview.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1973/11//
VL  - 10
IS  - 6
M3  - Article
SP  - 571
EP  - 577
SN  - 00485772
AB  - Previous work has demonstrated a consistent increase in diastolic blood pressure during an interview relative to a word association test. A consideration of normal cardiovascular mechanisms suggests that such increased diastolic pressure could be associated with decreased forearm blood flow. This expectation is at variance with previous studied in which psychological stimuli have been associated only with increased forearm blood flow. Forearm blood flow and pulse rate were measured during rest periods and during a word association test and an interview in 8 normal volunteers and 8 psychiatric inpatients. Twelve of the 16 Ss showed a decrease in forearm blood flow during the interview, thus confirming our expectation. That this decrease is an active response, rather than a passive fall, is suggested by the finding of increased heart rate during the interview. The cardiovascular responses of the patient group differed in some respects form those of the normal group. We hypothesize that the attentional deficit of the schizophrenics in the patients sample may have contributed to this difference. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLOOD pressure
KW  - CARDIOVASCULAR system
KW  - BLOOD flow
KW  - SCHIZOPHRENIA
KW  - PSYCHOSES
KW  - HEART beat
KW  - Forearm blood flow
KW  - Heart rate
KW  - Interview psychophysiology.
N1  - Accession Number: 11728898; Williams Jr., Redford B. 1 Frankel, Bernard L. 1 Galin, J. Christian 1 Weiss, James L. 1; Affiliation:  1: Laboratory of Clinical Psychobiology, Laboratory of Clinical Psychopharmacology, Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health.; Source Info: Nov1973, Vol. 10 Issue 6, p571; Subject Term: BLOOD pressure; Subject Term: CARDIOVASCULAR system; Subject Term: BLOOD flow; Subject Term: SCHIZOPHRENIA; Subject Term: PSYCHOSES; Subject Term: HEART beat; Author-Supplied Keyword: Forearm blood flow; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Interview psychophysiology.; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1469-8986.ep11728898
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2005-16484-020
AN  - 2005-16484-020
AU  - Shore, Milton F.
AU  - Jones, Robert E.
ED  - Shore, Milton F.
T1  - Psychological Research on Drug Addicts.
JF  - Professional Psychology
JO  - Professional Psychology
JA  - Prof Psychol
Y1  - 1973/11//
VL  - 4
IS  - 4
SP  - 468
EP  - 474
CY  - US
PB  - American Psychological Association
SN  - 0033-0175
N1  - Accession Number: 2005-16484-020. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Addiction; Experimentation; Treatment. Classification: Substance Abuse & Addiction (3233). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Nov, 1973. Copyright Statement: American Psychological Association. 1973. 
AB  - At the Addiction Research Center at Lexington, NIMH has for over two decades been actively researching narcotic drugs and their antagonists, but the Clinical Research Center's mission is oriented toward characteristics of drug abusers and their psychosocial treatment, not toward the characteristics of narcotic agents and their antagonists or less noxious substitutes. The Lexington Center has exchanged research information with other federal agencies concerned with drug addiction and with many of the larger state and community programs. This 'progress' report is intended mainly to establish communication with psychologists who are working in settings partly but not exclusively concerned with the prevention, treatment, or rehabilitation of drug addicts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological research
KW  - drug addicts
KW  - psychosocial treatment
KW  - characteristics of drug abusers
KW  - 1973
KW  - Drug Abuse
KW  - Drug Addiction
KW  - Experimentation
KW  - Treatment
KW  - 1973
DO  - 10.1037/h0021450
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06244-021
AN  - 2006-06244-021
AU  - Caron, Albert J.
T1  - Child Development à la Russe.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1973/11//
VL  - 18
IS  - 11
SP  - 539
EP  - 540
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06244-021. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Caron, Albert J.; National Institute of Mental Health, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Developmental Psychology. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Zaporozhets, A. V.; Elkonin, D. B. The Psychology of Preschool Children=Cambridge, Mass.: MIT Press, 1971. Pp. xxiii + 376. $12.50; 1971. Page Count: 2. Issue Publication Date: Nov, 1973. 
AB  - Reviews the book, The Psychology of Preschool Children by A. V. Zaporozhets and D. B. Elkonin (see record [rid]1972-10572-000[/rid]). This book constitutes the standard Soviet reference on research in early child development and is widely used as a text in universities and pedagogical institutes throughout the Soviet Union. In sum, this book provides a picture of Soviet developmental psychology. It portrays a discipline still trying to gain an objective scientific foothold within the limited confines of official doctrine. Given this constraint, as well as the prolonged isolation of Soviet psychology from the international scientific community, the slenderness of the achievement is not to be gainsaid. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child development
KW  - developmental psychology
KW  - preschool children
KW  - Soviet psychology
KW  - 1973
KW  - Childhood Development
KW  - Developmental Psychology
KW  - 1973
U2  - Zaporozhets, A. V.; Elkonin, D. B. (1971); The Psychology of Preschool Children; Cambridge, Mass.: MIT Press, 1971. Pp. xxiii + 376. $12.50
DO  - 10.1037/0011733
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - PARLOFF, MORRIS B.
T1  - A Psychodiagnostic Instrument.
JO  - Science
JF  - Science
Y1  - 1973/11/09/
VL  - 182
IS  - 4112
M3  - Article
SP  - 574
EP  - 575
SN  - 00368075
N1  - Accession Number: 85117554; PARLOFF, MORRIS B. 1; Affiliations: 1: Clinical Research Branch, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 11/ 9/1973, Vol. 182 Issue 4112, p574; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GILLER JR., EARL L.
AU  - SCHRIER, BRUCE K.
AU  - SHAINBERG, ASHER
AU  - FISK, H. RONALD
AU  - NELSON, PHILLIP G.
T1  - Choline Acetyltransferase Activity Is Increased in Combined Cultures of Spinal Cord and Muscle Cells from Mice.
JO  - Science
JF  - Science
Y1  - 1973/11/09/
VL  - 182
IS  - 4112
M3  - Article
SP  - 588
EP  - 589
SN  - 00368075
AB  - The activity of choline acetyltransferase was more than tenfold greater in combined cultures of spinal cord and muscle cells than in cultures of spinal cord cells alone. This increase was associated with the formation of functional neuromuscular junctions in culture. Counts of silver-stained cells and determinations of other enzyme activities indicated that the increased choline acetyltransferase activity was not due to nonspecific neuronal survival but reflected greater activity in the surviving neurons. Hence, muscle had a marked, highly specific trophic effect on the cholinergic neurons that innervated it. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117563; GILLER JR., EARL L. 1; SCHRIER, BRUCE K. 1; SHAINBERG, ASHER 1; FISK, H. RONALD 1; NELSON, PHILLIP G. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland; Issue Info: 11/ 9/1973, Vol. 182 Issue 4112, p588; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - POTTER, MICHAEL
AU  - SKLAR, MARSHALL D.
AU  - ROWE, WALLACE P.
T1  - Rapid Viral Induction of Plasmacytomas in Pristane-Primed BALB/c Mice.
JO  - Science
JF  - Science
Y1  - 1973/11/09/
VL  - 182
IS  - 4112
M3  - Article
SP  - 592
EP  - 594
SN  - 00368075
AB  - Strain BALB/c mice were injected intraperitoneally with 0.5 milliliter of pristane, and 39 to 56 days later they were infected with Abelson murine leukemia virus, which is a lymphosarcomagenic variant of Moloney virus. Fifty-eight percent of the mice developed lymphosarcoma, and 28 percent developed immunoglobulin- producing plasmacytomas within 20 to 93 days (77 to 149 days after the pristane injection). Two of 57 control mice developed plasmacytomas at days 138 and 166 after a single injection of pristane; no plasmacytomas were found in mice treated with virus alone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117565; POTTER, MICHAEL 1; SKLAR, MARSHALL D. 2; ROWE, WALLACE P. 2; Affiliations: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Issue Info: 11/ 9/1973, Vol. 182 Issue 4112, p592; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HOLLINSHEAD, ARIEL C.
AU  - OBONG LEE
AU  - CHRETIEN, PAUL B.
AU  - TARPLEY, JOHN L.
AU  - RAWLS, WILLIAM E.
AU  - ADAM, ERVIN
T1  - Antibodies to Herpesvirus Nonvirion Antigens in Squamous Carcinomas.
JO  - Science
JF  - Science
Y1  - 1973/11/16/
VL  - 182
IS  - 4113
M3  - Article
SP  - 713
EP  - 715
SN  - 00368075
AB  - Serums from tumor-bearing patients, cured patients, and normal subjects were examined for antibodies to the separated complement-fixing reactive components of nonvirion antigens of herpesvirus type 1 and type 2. The occurrence of antibodies to the antigens was similar in serums from tumor-bearing patients and cured patients. Antibodies to the antigens were observed among 21 of 24 (87 percent) cervical cancer cases, 44 of 49 (90 percent) laryngeal cancer cases, 15 of 24 (62 percent) cases of squamous cell carcinomas of the head and neck excluding the larynx, 2 of 24 (8 percent) nonsquamous cell cancer cases, and 3 of 51 (6 percent) normal subjects. By contrast, no differences were found in the titers of neutralizing antibodies to the virus in serums from laryngeal cancer patients and controls. The observations support an etiologic role of herpesviruses in cervical cancer and in laryngeal cancer, and possibly other squamous cell cancers of the head and neck. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117606; HOLLINSHEAD, ARIEL C. 1; OBONG LEE 1; CHRETIEN, PAUL B. 2; TARPLEY, JOHN L. 2; RAWLS, WILLIAM E. 3; ADAM, ERVIN 3; Affiliations: 1: Laboratory for Virus and Cancer Research, Department of Medicine, George Washington University, Washington, D.C. 20037; 2: Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Departments of Virology and Epidemiology, Baylor University College of Medicine, Texas Medical Center, Houston 77025; Issue Info: 11/16/1973, Vol. 182 Issue 4113, p713; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - GANER, HAROLD
T1  - Pentobarbital: Selective Depression of Excitatory Postsynaptic Potentials.
JO  - Science
JF  - Science
Y1  - 1973/11/16/
VL  - 182
IS  - 4113
M3  - Article
SP  - 720
EP  - 722
SN  - 00368075
AB  - The effects of pentobarbital (Nembutal) on synaptic transmission and postsynaptic potentials were studied by the use of several invertebrate preparations. Pentobarbital selectively and reversibly depressed both excitatory postsynaptic potentials and sodium-dependent postsynaptic responses to putative excitatory transmitters without affecting either inhibitory postsynaptic potentials or chlorideand potassium-dependent postsynaptic responses to putative transmitters. A selective depression of postsynaptic excitatory events was also observed with other central nervous system depressants (ethanol, chloroform, chloralose, diphenylhydantoin, and urethane). The results suggest that central and peripheral depression observed during general anesthesia is due to a selective depression of excitatory synaptic events. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117609; BARKER, JEFFERY L. 1; GANER, HAROLD 1; Affiliations: 1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/16/1973, Vol. 182 Issue 4113, p720; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - SPORN, MICHAEL B.
AU  - DUNLOP, NANCY M.
AU  - YUSPA, STUART H.
T1  - Retinyl Acetate: Effect on Cellular Content of RNA in Epidermis in Cell Culture in Chemically Defined Medium.
JO  - Science
JF  - Science
Y1  - 1973/11/16/
VL  - 182
IS  - 4113
M3  - Article
SP  - 722
EP  - 723
SN  - 00368075
AB  - Cell cultures of epidermis from newborn mice were established in chemically defined medium. Additions of retinyl acetate to these cultures caused a significant increase in cellular RNA content. Addition of insulin and hydrocortisone to the cultures potentiated the eflect of retinyl acetate on cellular RNA content. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117610; SPORN, MICHAEL B.; DUNLOP, NANCY M.; YUSPA, STUART H. 1; Affiliations: 1: Experimental Pathology Branch, Carcinogenesis Program, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 11/16/1973, Vol. 182 Issue 4113, p722; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TULLY, J. G.
AU  - WHITCOMB, R. F.
AU  - BOVE, J. M.
AU  - SAGLIO, P.
T1  - Plant Mycoplasmas: Serological Relation between Agents Associated with Citrus Stubborn and Corn Stunt Diseases.
JO  - Science
JF  - Science
Y1  - 1973/11/23/
VL  - 182
IS  - 4114
M3  - Article
SP  - 827
EP  - 829
SN  - 00368075
AB  - Growth-inhibition and precipitin tests established that antigens of the helical iniycoplasmtia-like organism (Spiroplasma citri) associated with citrus stubborn disease are serologically related to antigens in corn infected with stunt disease but not in healthy corn. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87436975; TULLY, J. G. 1; WHITCOMB, R. F. 2; BOVE, J. M. 3; SAGLIO, P. 3; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Plant Protection Institute, U.S. Department of Agriculture, Beltsville, Maryland 20705; 3: Station de Physiologie et de Biochitnie Vegetales, Centre de Recherches de Bordeaucx, Institut National le la Recherche Agronomzique, 33 Pont-de-la-Maye, France; Issue Info: 11/23/1973, Vol. 182 Issue 4114, p827; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GORDEN, P.
AU  - LESNIAK, M. A.
AU  - HENDRICKS, C. M.
AU  - ROTH, J.
T1  - "Big" Growth Hormone Components from Human Plasma: Decreased Reactivity Demonstrated by Radioreceptor Assay.
JO  - Science
JF  - Science
Y1  - 1973/11/23/
VL  - 182
IS  - 4114
M3  - Article
SP  - 829
EP  - 831
SN  - 00368075
AB  - Plasma as well as pituitary itninunoreactive human growth hormone (HGH) comprises at least two discrete comlponents which have been designated as "big" HGH and "little" HGH. Using a newly developed radioreceptor assay, which depends on the ability of a substance to coinpete with labeled HGH for binding sites on cultured human lymphocytes, we find that the big HGH component fromz both normnal and acroinegalic subjects has much less activity in the radioreceptor assay than in the radioimmunoassay, whereas the little HGH comnponient has simnilar activity in both assays. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87436936; GORDEN, P. 1; LESNIAK, M. A. 1; HENDRICKS, C. M. 1; ROTH, J. 1; Affiliations: 1: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/23/1973, Vol. 182 Issue 4114, p829; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Stephens, R. C.;
AU  - Weppner, R. S.;
T1  - Legal and illegal use of methadone: one year later
CT  - Legal and illegal use of methadone: one year later
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1973/12/01/
VL  - 130
IS  - Dec
SP  - 1391
EP  - 1394
SN  - 0002953X
AD  - Reprints: New York State Narcotic Addiction Control Commission, 1855 Broadway, New York, New York 10023
AD  - National Institute of Mental Health Clinical Research Center, Lexington, Kentucky
N1  - Accession Number: 11-3858; Language: English; Chemical Name: Methadone--76-99-3; References: 1; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: C. Robert Sturwold
N2  - The results of a study which shows that the use of methadone, both legal and illegal, has increased are discussed. In a sample of 469 newly admitted narcotic addicts, 75% had experience with methadone and 52% had used it illegally. Compared to a previous study, the role of the pusher as a supplier of illicit methadone has declined while other suppliers have become more important. The low cost of methadone and its ease of procurement are suggested as reasons for the increase in its illegal use.
KW  - Methadone--abuse-;
KW  - Drug abuse--methadone--and legal use, discussion, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Buchsbaum, M.;
AU  - Wender, P.;
T1  - Average evoked responses in normal and minimally brain dysfunctioned children treated with amphetamine
CT  - Average evoked responses in normal and minimally brain dysfunctioned children treated with amphetamine
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1973/12/01/
VL  - 29
IS  - Dec
SP  - 764
EP  - 770
AD  - National Institute of Mental Health, Building 10, Room 2N-315, Bethesda, Maryland 20014
N1  - Accession Number: 11-4865; Language: English; Chemical Name: Amphetamine--300-62-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine; References: 25; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Visual and auditory average evoked responses in 24 minimal brain dysfunction children, 6 to 12 years old, were considered immature when compared to responses seen in 48 normal children; amphetamine effects on these responses was studied. Minimal brain dysfunction children who received amphetamine, 10 to 20 mg./day, and showed clinical improvement tended to display immature response patterns off drug to a greater extent than minimally brain dysfunction amphetamine nonresponders.
KW  - Amphetamine--minimal brain dysfunction-;
KW  - Central nervous system stimulants--amphetamine--minimal brain dysfunction, therapy, immature average evoked responses, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Horowitz, Herschel S.
T1  - A review of systemic and topical fluorides for the prevention of dental caries.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1973/12//
VL  - 1
IS  - 3
M3  - Article
SP  - 104
EP  - 114
SN  - 03015661
AB  - Because community fluoridation constitutes nearly an ideal public health method, it should be the cornerstone of all national programs of dental caries prevention. Where fluoridation is not possible for technical or political reasons, some alternative methods of providing benefits from systemic fluorides are available, including school water fluoridation, dietary supplements of fluoride and the fluoridation of salt. Dietary supplements of fluoride are not recommended for pregnant women for caries protection in their offspring. In areas with low fluoride levels in drinking water, solutions of 2 % sodium fluoride, 8% stannous fluoride and acidulated phosphate-fluoride (APF) (1.2 % F ion) and the same concentration of an APF gel applied professionally can prevent dental caries. APF is currently the choice for these applications. Fluoride prophylaxis pastes should be used, particularly when a topical fluoride application is not scheduled to follow the prophylaxis. Effective unsupervised topical fluoride applications occur with use of fluoride containing dentifrices. Supervised self-applications of fluoride for public health programs overcome the inefficiencies of individual professional applications. Many studies continue to be reported on mouth-rinsing with fluoride solutions, toothbrushing with fluoride solutions and gels, toothbrushing with fluoride prophylaxis pastes and the application of fluoride gels in mouthpieces. Fluoride mouth-rinsing has several advantages. Self-application of fluorides will undoubtedly become the method of choice for delivering topical fluorides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL caries
KW  - DENTAL pathology
KW  - FLUORIDES
KW  - ORAL hygiene products
KW  - DENTISTRY
KW  - PUBLIC health
KW  - dental
KW  - dental caries
KW  - fluorides
KW  - prevention
N1  - Accession Number: 12088111; Horowitz, Herschel S. 1; Affiliation:  1: National Institute of Dental Research, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Maryland, U.S.A.; Source Info: Dec1973, Vol. 1 Issue 3, p104; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: FLUORIDES; Subject Term: ORAL hygiene products; Subject Term: DENTISTRY; Subject Term: PUBLIC health; Author-Supplied Keyword: dental; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: fluorides; Author-Supplied Keyword: prevention; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1600-0528.ep12088111
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schein, Philip S.
T1  - Chemotherapy in advanced ovarian cancer.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1973/12//
VL  - 28
IS  - 12
M3  - Article
SP  - 89
EP  - 95
SN  - 0016867X
N1  - Accession Number: 17524996; Schein, Philip S. 1; Source Information: Dec1973, Vol. 28 Issue 12, p89; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3239
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Carlson, Rae
AU  - Levy, Nissim
T1  - Studies of Jungian typology: I.  Memory, social perception, and social action.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1973/12//
VL  - 41
IS  - 4
M3  - Article
SP  - 559
EP  - 576
PB  - Wiley-Blackwell
SN  - 00223506
N1  - Accession Number: 9027624; Carlson, Rae 1 Levy, Nissim 2; Affiliation:  1: National Institute of Mental Health.  2: Howard University.; Source Info: Dec73, Vol. 41 Issue 4, p559; Number of Pages: 18p; Document Type: Article
L3  - 10.1111/1467-6494.ep9027624
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ellenberg, Jonas H.
T1  - The Joint Distribution of the Standardized Least Squares Residuals from a General Linear Regression.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1973/12//
VL  - 68
IS  - 344
M3  - Article
SP  - 941
SN  - 01621459
AB  - In this article the p-variate joint distribution is derived for a subset of p of the n standardized least squares residuals from a general linear regression. The resulting distribution is a standardized version of the Inverted-Student Function [8, p. 259]. An application of this result to the problem of detection of outliers is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - REGRESSION analysis
KW  - ESTIMATION theory
KW  - MATHEMATICAL statistics
KW  - PROBABILITY theory
KW  - LEAST squares
N1  - Accession Number: 4603783; Ellenberg, Jonas H. 1; Affiliations: 1: Head, Section on Experimental Statistics, Office of Biometry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Dec73, Vol. 68 Issue 344, p941; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: REGRESSION analysis; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Subject Term: LEAST squares; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rosenberg, E.;
AU  - Powell, R.;
T1  - Active tumor immunotherapy with BCG
CT  - Active tumor immunotherapy with BCG
JO  - South Med. J.
JF  - South Med. J.
Y1  - 1973/12/01/
VL  - 66
IS  - Dec
SP  - 1359
EP  - 1363
AD  - Reprints: Division of Nuclear Medicine and Oncology, University of Miami School of Medicine, Miami, Florida 33152
AD  - Immunology Branch and Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-2982; Language: English; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines; References: 20; Journal Coden: SMJOAV; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Tim R. Covington
N2  - One patient with widely metastatic carcinoma of the breast was treated with BCG injected into subcutaneous tumor nodules in an effort to produce a significant clinical remission. Selected subcutaneous nodules of the anterior chest were injected with 0.1 ml. of freshly suspended BCG in an effort to boost the immune response. Injected tumor nodules showed an intense inflammatory reaction and a marked decrease in tumor cells. All injected nodules involuted within 2 months. The use of BCG did not, however, check the overall progression of the disease as the number of subcutaneous nodules continued to increase and a cervical node enlarged. Although BCG immunotherapy has been effective in various neoplasma of animals and man, it was not clinically effective in this patient.
KW  - BCG vaccines--carcinomas-;
KW  - Immunosuppressive agents--BCG vaccines--carcinomas, breast, lack, effects, on remission, case report;
KW  - Drug administration--routes--BCG vaccines, injections into S.C. nodules, breast cancer therapy, case report;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - FEINSTONE, STEPHEN M.
AU  - KAPIKIAN, ALBERT Z.
AU  - PURCELI, ROBERT H.
T1  - Hepatitis A: Detection by Immune Electron Microscopy of a Viruslike Antigen Associated with Acute Illness.
JO  - Science
JF  - Science
Y1  - 1973/12/07/
VL  - 182
IS  - 4116
M3  - Article
SP  - 1026
EP  - 1028
SN  - 00368075
AB  - Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85178809; FEINSTONE, STEPHEN M. 1; KAPIKIAN, ALBERT Z. 1; PURCELI, ROBERT H. 1; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 12/ 7/1973, Vol. 182 Issue 4116, p1026; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ALLEN, GORDON
AU  - PETTIGREW, KAREN D.
AU  - ERLENMEYER-KIMLING, L.
AU  - STERN, SAMUEL E.
AU  - SCARR-SALAPATEK, SANDRA
T1  - Heritability of IQ by Social Class: Evidence Inconclusive.
JO  - Science
JF  - Science
Y1  - 1973/12/07/
VL  - 182
IS  - 4116
M3  - Article
SP  - 1042
EP  - 1047
SN  - 00368075
N1  - Accession Number: 85178816; ALLEN, GORDON 1; PETTIGREW, KAREN D. 2; ERLENMEYER-KIMLING, L. 3; STERN, SAMUEL E. 4; SCARR-SALAPATEK, SANDRA 5; Affiliations: 1: Mental Health Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Biometry Branch, National Institute of Mental Health; 3: Department of Medical Genetics, New York State Psychiatric Institute, New York 10032; 4: Department of Sociology, Georgia State University, Atlanta 30303; 5: Institute of Child Development, University of Minnesota, Minneapolis 55455; Issue Info: 12/ 7/1973, Vol. 182 Issue 4116, p1042; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carman, J. S.;
AU  - Tucker, L. S.;
T1  - Benztropine in childhood hyperkinesis
CT  - Benztropine in childhood hyperkinesis
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1973/12/08/
VL  - 2
IS  - Dec 8
SP  - 1337
EP  - 1338
SN  - 00237507
AD  - National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-2217; Language: English; Chemical Name: Benztropine--86-13-5; References: 9; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2  - Suppression of the aggressive, antisocial component of the hyperkinetic syndrome in children with benztropine and possible mechanisms of action are discussed.
KW  - Benztropine--hyperkinesis-;
KW  - Hyperkinesis--benztropine--effects, on aggressive, antisocial behavior, in children;
KW  - Mechanism of action--benztropine--hyperkinesis, effects on aggressive, antisocial behavior, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - PERTEL, RUTH
T1  - Host-Finding Strategies.
JO  - Science
JF  - Science
Y1  - 1973/12/14/
VL  - 182
IS  - 4117
M3  - Article
SP  - 1124
EP  - 1125
SN  - 00368075
N1  - Accession Number: 85178837; PERTEL, RUTH 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; Issue Info: 12/14/1973, Vol. 182 Issue 4117, p1124; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DVORNIK, D.
AU  - SIMARD-DUQUESNE, N.
AU  - KRAMI, M.
AU  - SESTANJ, K.
AU  - GABBAY, K. H.
AU  - KINOSHITA, J. H.
AU  - VARMA, S. D.
AU  - MEROLA, L. O.
T1  - Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor.
JO  - Science
JF  - Science
Y1  - 1973/12/14/
VL  - 182
IS  - 4117
M3  - Article
SP  - 1146
EP  - 1148
SN  - 00368075
AB  - An orally active inhibitor of aldose redlictase, 1,3-dioxo-1H-benz[de]- isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concenttrations of galactose. When given orally, A Y-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactoseiniic rats with AY-22,284 effectively suppressed the formnation of cataracts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85178849; DVORNIK, D. 1; SIMARD-DUQUESNE, N. 1; KRAMI, M. 1; SESTANJ, K. 1; GABBAY, K. H. 2; KINOSHITA, J. H. 3; VARMA, S. D. 3; MEROLA, L. O. 3; Affiliations: 1: Department of Biochemistry, Ayerst Research Laboratories, Montreal, Quiebec, Canada; 2: Cell Biology, Laboratory, Endocrine Division, Children's Hospital Medical Centter, Boston, Massachusetts 02115, and Department of Pediatrics, Harvard Medical School, Boston; 3: Laboratory of Vision Research, National Eye Institute, Bethescda, Maryland 20015; Issue Info: 12/14/1973, Vol. 182 Issue 4117, p1146; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WHITCOMB, R. F.
AU  - TULLY, J. G.
AU  - BOVÉ, J. M.
AU  - SAGLIO, P.
T1  - Spiroplasmas and Acholeplasmas: Multiplication in Insects.
JO  - Science
JF  - Science
Y1  - 1973/12/21/
VL  - 182
IS  - 4118
M3  - Article
SP  - 1251
EP  - 1253
SN  - 00368075
AB  - The helical wall-free microorganism, Spiroplasma citri, which is associated with citrus stubborn, a disease with no known vector, multiplied in the leafhopper vector of corn stunt but multiplied to higher titer in the vector of aster yellows and decreased the longevity of that insect. Acholeplasma laidlawii and A. granularum also multiplied in both leafhoppers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85178888; WHITCOMB, R. F. 1; TULLY, J. G. 2; BOVÉ, J. M. 3; SAGLIO, P. 3; Affiliations: 1: U.S. Department of Agriculture, Agricultural Research Service, Plant Protection Institute, Beltsville, Maryland 20705; 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 3: Station de Physiologie et de Biochimie Végétales, Centre de Recherches de Bordeaux, Institut National de la Recherche Argonomique, 33, Pont-de-le Maye, France; Issue Info: 12/21/1973, Vol. 182 Issue 4118, p1251; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CARPENTER JR., WILLIAM T.
AU  - STRAUSS, JOHN S.
AU  - BARTKO, JOHN J.
T1  - Flexible System for the Diagnosis of Schizophrenia: Report from the WHO International Pilot Study of Schizophrenia.
JO  - Science
JF  - Science
Y1  - 1973/12/21/
VL  - 182
IS  - 4118
M3  - Article
SP  - 1275
EP  - 1278
SN  - 00368075
AB  - Behavioral data on a large patient group were collected by investigators from nine countries in the International Pilot Study of Schizophrenia, sponsored by the World Health Organization. The data on half the group were analyzed to derive a system of 12 signs and symptoms for the identification of schizophrenia, as this disorder is diagnosed in many centers throughout the world. The findings were replicated with the other half of the patient group. The criteria constitute an operational method for identifying patients who would be commonly considered schizophrenic in many centers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85178900; CARPENTER JR., WILLIAM T. 1; STRAUSS, JOHN S. 2; BARTKO, JOHN J. 3; Affiliations: 1: Psychiatric Assessment Section, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14620; 3: Biometry Branch, National Institute of Mental Health; Issue Info: 12/21/1973, Vol. 182 Issue 4118, p1275; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-06011-000
AN  - 9999-06011-000
AU  - Derogatis, Leonard R.
AU  - Lipman, Ronald S.
AU  - Rickels, Karl
AU  - Uhlenhuth, E. H.
AU  - Covi, Lino
T1  - Hopkins Symptom Checklist
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1974///
AD  - Derogatis, Leonard R., Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, United States, 21205
AV  - Commercial: No; Permissions: Not Specified; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-06011-000. Acronyms: HSCL. Partial author list: First Author & Affiliation: Derogatis, Leonard R.; Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States. Release Date: 20130211. Correction Date: 20160711. Instrument Type: Checklist. Test Format: Participants rate their level of distress on each item on a 4-point Likert-type scale from 1 'not at all' to 4 'extreme.'. Language: English. Constructs: Psychological Distress Symptoms; Classification: Physical Health/Illness Related Assessment (7300). Population: Human (10). 
N2  - Administration Method: Paper
AB  - Purpose: The Hopkins Symptom Checklist is a self-report psychological symptom inventory.
AB  - Description: The Hopkins Symptom Checklist (HSCL; Derogatis et al, 1974) is a self-report symptom inventory. The HSCL is comprised of 58 items which are representative of the symptom configurations commonly observed among outpatients. It is scored on five underlying symptom dimensions-somatization, obsessive-compulsive, interpersonal sensitivity, anxiety and depression--which have been identified in repeated factor analyses. A series of studies have established the factorial invariance of the primary symptom dimensions, and substantial evidence is given in support of their construct validity. Normative data in terms of both discrete symptoms and primary symptom dimensions are from 2,500 subjects (800 psychiatric outpatients and 700 normal individuals). Indices of pathology reflect both intensity of distress and prevalence of symptoms in the normative samples. A series of studies have established the factorial invariance of the primary symptom dimensions, and substantial evidence is given in support of their construct validity. The evolution and development of the instrument has not permanently crystallized with the 58-item HSCL. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Hopkins Symptom Checklist
KW  - Psychological Assessment
KW  - Psychological Symptoms
KW  - Self Report
KW  - Test Development
U5  - Hopkins Symptom Checklist (HSCL) [Test Development]The Hopkins Symptom Checklist (HSCL): A self-report symptom inventory. (AN: 1974-21363-001 from PsycINFO) Derogatis, Leonard R.; Lipman, Ronald S.; Rickels, Karl; Uhlenhuth, E. H.; Covi, Lino; Jan, 1974. Source: Behavioral Science. 19(1), General Systems Science Foundation, US; Jan, 1974; Administration: Paper Population: Human; Samples: Psychiatric Outpatients and Inpatients Keywords: Hopkins Symptom Checklist; Psychological Assessment; Psychological Symptoms; Self Report; Test Development; Subjects: Checklist (Testing); Psychiatric Symptoms; Psychological Assessment; Self-Report; Symptom Checklists; Test Construction;
DO  - 10.1037/t06011-000
L3  - Full; Full text; 999906011_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-15303-000
AN  - 9999-15303-000
AU  - Beck, Aaron T.
AU  - Resnik, Aaron T.
AU  - Lettieri, Dan J.
T1  - Suicide Intent Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1974///
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-15303-000. Other Names: Suicidal Intent Scale; Suicide Intent Scales. Acronyms: SIS. Partial author list: First Author & Affiliation: Beck, Aaron T.; University of Pennsylvania, Philadelphia, Pennsylvania, United States. Release Date: 20140113. Correction Date: 20151207. Instrument Type: Rating Scale. Test Location: Table 3-2, Page 54. Test Format: The items on the Suicide Intent Scale are either forced-choice responses, or consist of three alternative statements graded in intensity from 0 to 2.. Language: English. Constructs: Suicidal Intent; Classification: Emotional States, Emotional Responses, and Motivation (6000). Population: Human (10); Male (30); Female (40). Other Versions: 9999-44545-000, Suicide Intent Scale--Chinese Version, Translation. 
N2  - Administration Method: Interview
AB  - Purpose: The purpose of the Suicide Intent Scale is to record data regarding the intensity of the attempter's wish to die at the time of the attempt.
AB  - Description: The Suicide Intent Scale (SIS; Beck, Resnick, & Lettieri, 1974) is a 20-item scale designed to record data regarding the intensity of the attempter's wish to die at the time of the attempt. In order to assess this expectancy, the scale is completed on the basis of retrospective data obtained from the patient and relevant observers, such as family and police. The scale is divided into three sections. Each item consists of three alternative statements graded in intensity from 0 to 2. The total score consists of the summed scores for each item. The first section, Circumstances Related to Suicidal Attempt, deals mainly with factual aspects of the attempt and the events surrounding it. The second section, Self Report, is used to record retrospectively the patient's thoughts and feelings at the time of the attempt. The third section is unscored, since the weighting of the alternatives is uncertain at this time. Following an intake interview, each interviewer independently completes the scale. The total intent score for each case is computed. The coefficient in 45 cases was found to have been r = .95 (inter-rater reliability). After correction for attenuation (Spearman Brown), the correlation coefficient was .82 (internal consistency). (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Interrater Reliability
KW  - Test Development
KW  - Suicide Intent Scale
KW  - Internal Consistency
U5  - Suicide Intent Scale (SIS) [Test Development]Development of suicidal intent scales. (AN: 1975-05602-003 from PsycINFO) Beck, Aaron T.; Schuyler, Dean; Herman, Ira; 1974. Source: The prediction of suicide., Beck, Aaron T.; Resnik, Harvey L.; Lettieri, Dan J.; Charles Press Publishers, Oxford, England; Administration: Interview Population: Human; Male; Female; Sample: Suicidal Patients; Location: United States Keywords: Interrater Reliability; Test Development; Suicide Intent Scale; Internal Consistency; Subjects: Interrater Reliability; Rating Scales; Suicidal Ideation; Test Construction; Test Reliability;
DO  - 10.1037/t15303-000
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
TY  - GEN
AU  - Seamen, W. E.;
AU  - Ishak, K. G.;
AU  - Plotz, P. H.;
T1  - Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus
CT  - Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1974/01/01/
VL  - 80
IS  - Jan
SP  - 1
EP  - 8
SN  - 00034819
AD  - Arthritis and Rheumatology Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; and Hepatic and Pediatric Pathology Branch, Armed Forces Institute of Pathology, Washington, D.C.
N1  - Accession Number: 11-3906; Language: English; Chemical Name: Aspirin--50-78-2; References: 46; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity
N2  - Three patients with systemic lupus erythematosus were noted to have evidence of liver injury that proved to be related to aspirin therapy. In 2 of the patients, the initial presentation mimicked chronic active hepatitis. A liver biopsy obtained from one of the patients was also consistent with the diagnosis of chronic active hepatitis, and the biopsy from a second patient showed acute hepatocellular injury. Aspirin should be considered among causes of hepatitis, particularly in patients with lupus erythematosus.
KW  - Aspirin--toxicity-;
KW  - Toxicity--aspirin--hepatitis, in systemic lupus erythematosus patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Raskin, A.;
AU  - Schulterbrandt, J. B.;
AU  - Reatig, N.;
AU  - Crook, T. H.;
AU  - Odle, D.;
T1  - Depression subtypes and response to phenelzine, diazepam, and a placebo
CT  - Depression subtypes and response to phenelzine, diazepam, and a placebo
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/01/01/
VL  - 30
IS  - Jan
SP  - 66
EP  - 75
AD  - National Institute of Mental Health, Psychopharmacology Research Branch, Rm 9-101, 5600 Fishers Lane, Rockville, Maryland 20952
N1  - Accession Number: 12-0306; Language: English; Trade Name: Nardil--Valium; Generic Name: Phenelzine; Diazepam; Chemical Name: Diazepam--439-14-5 Phenelzine--51-71-8; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants phenelzine, comparison, diazepam (28:16.08); AHFS Class: Tranquilizers diazepam, comparison, phenelzine; References: 62; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - A 7-week double blind study of 325 newly admitted depressed patients randomly assigned to treatment with either diazepam, phenelzine or placebo is presented. Median daily dosages were 30 mg. of diazepam and 45 mg. of phenelzine. The major study finding was the differential effects of diazepam (Valium) for patients categorized as anxious and hostile depressions. There was a significant number of anxious-depressive patients who were diazepam responders, i.e., their symptoms subsided on this treatment and became worse when this drug was discontinued. In contrast, diazepam was a poor treatment for the hostile depressions. These patients were restless, anxious, negativistic, suspicious and irritable when they entered the study. These symptoms persisted on diazepam and improved on either phenelzine (Nardil) or a placebo.
KW  - Diazepam--comparison, phenelzine-;
KW  - Phenelzine--comparison, diazepam-;
KW  - Antidepressants--phenelzine, comparison, diazepam--depression, anxious versus hostile, therapy, in patients;
KW  - Tranquilizers--diazepam, comparison, phenelzine--depression, anxious versus hostile, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - CHAP
ID  - 2007-11499-023
AN  - 2007-11499-023
AU  - Engel, Bernard T.
AU  - Bleecker, Eugene R.
ED  - Obrist, Paul A.
ED  - Black, A. H.
ED  - Brener, Jasper
ED  - DiCara, Leo V.
ED  - Obrist, Paul A., (Ed)
ED  - Black, A. H., (Ed)
ED  - Brener, Jasper, (Ed)
ED  - DiCara, Leo V., (Ed)
T1  - Application of operant conditioning techniques to the control of the cardiac arrhythmias.
T2  - Cardiovascular psychophysiology: Current issues in response mechanisms, biofeedback and methodology.
Y1  - 1974///
SP  - 456
EP  - 476
CY  - New Brunswick, NJ, US
PB  - AldineTransaction
SN  - 0-202-36146-2
SN  - 978-0-202-36146-8
N1  - Accession Number: 2007-11499-023. Partial author list: First Author & Affiliation: Engel, Bernard T.; Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute of Child Health and Human Development, Baltimore, MD, US. Reprinted: 2008. Release Date: 20080414. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-202-36146-2, Paperback; 978-0-202-36146-8, Paperback. Language: English. Major Descriptor: Arrhythmias (Heart); Cardiovascular Reactivity; Cardiovascular System; Operant Conditioning. Classification: Cardiovascular Disorders (3295). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 21. 
AB  - It is the intent of this chapter to review a number of studies which we and our colleagues have carried out in an attempt to evaluate the clinical application of operant conditioning techniques in the control of cardiac arrhythmias. The research we will be describing here also was designed to enable us to learn more about the control mechanisms of the heart; however, that aspect of our work has been reviewed elsewhere (Engel 1972). Any considerations of mechanisms in this chapter will be limited to speculations about how operant conditioning procedures might be useful diagnostically or how these procedures might be therapeutically useful, both as adjuncts to other forms of therapy and by themselves. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - operant conditioning techniques
KW  - control mechanisms
KW  - cardiac arrhythmias
KW  - 1974
KW  - Arrhythmias (Heart)
KW  - Cardiovascular Reactivity
KW  - Cardiovascular System
KW  - Operant Conditioning
KW  - 1974
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Cohen, M. H.
AU  - Sibal, L. R.
AU  - Fink, Mary A.
T1  - Relative Importance of Viral and Neoantigens in Cytotoxic Reaction Against Murine Leukaemia Cells.
JO  - Immunology
JF  - Immunology
Y1  - 1974/01//
VL  - 26
IS  - 1
M3  - Article
SP  - 37
EP  - 48
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Monkeys and mice were immunized with Rauscher murine leukaemia virus. Two types of leukaemia virus preparations were used as immunogens. One preparation was derived from viraemic plasma and was highly purified by density gradient ultracentrifugation. The other preparation of Rauscher virus was derived from spleen cells and was contaminated with cell membranes. Following immunization with each of these preparations sensitive techniques were utilized to measure antiviral and antileukaemia cell ('cytotoxic') antibody levels on aliquots of the same antiserums. Multiple serums from each animal were tested during the weeks of immunization in order to establish a parallelism or lack of parallelism in the changes in cytotoxic and antiviral antibody levels. In each antiserum the cytotoxic and antiviral titres were virtually the same. This was true whether the animal had been immunized with a purified or a non-purified virus preparation. The presence or absence of contaminating cell membrane material in the immunizing material did not result in an antiserum with increased or decreased cytotoxic to antiviral antibody ratio. This indicated that cytotoxic antibody is probably not the result of immunization against cell membrane antigens ('neoantigens') as distinguished from virus or virion subunit antigens. Conversely, we found that leukaemia cells containing relatively little virus did not lyse in the presence of cytotoxic antibody prepared against either membrane-rich or membrane-poor virus preparations. This finding suggests that virus and not independent neoantigen renders the leukaemia cell lysable by cytotoxic antibody. Our studies therefore minimize the significance and even question the presence of neoantigens in Rauscher leukaemia cells, since the cytotoxic capability of anti-Rauscher antiserum is dependent on the presence of virus and not neoantigen in the immunizing preparations, and since virus and not neoantigen renders the infected cell lysable by anti-Rauscher antibody. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRACENTRIFUGATION
KW  - CELL membranes
KW  - CELLS
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - IMMUNITY
N1  - Accession Number: 12827705; Cohen, M. H. 1,2 Sibal, L. R. 1,2 Fink, Mary A. 1,2; Affiliation:  1: Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts  2: Immunology Section, Viral Leukemia and Lymphoma Branch, National Cancer Institute, Rational Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan74, Vol. 26 Issue 1, p37; Subject Term: ULTRACENTRIFUGATION; Subject Term: CELL membranes; Subject Term: CELLS; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNITY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Kuch, T D C
AU  - Magnuson, Robert
T1  - A network-oriented interactive system for computer-supported indexing
JO  - In Zunde, Pranas, Ed. Information Utilities. Proceedings Of The American Society For Information Science. Volume 11. 37th Annual Meeting, Atlanta, Georgia, October 13-17, 1974. 1974. Asis, Washington. P. 63-68. 1 Illus. 6 Ref. See Isa 74-3376/y
JF  - In Zunde, Pranas, Ed. Information Utilities. Proceedings Of The American Society For Information Science. Volume 11. 37th Annual Meeting, Atlanta, Georgia, October 13-17, 1974. 1974. Asis, Washington. P. 63-68. 1 Illus. 6 Ref. See Isa 74-3376/y
Y1  - 1974///
M3  - Book
AB  - 'indexing' covers a multitude of activities, from traditional human booking-indexing through key-word indexing to automatic generation of authority lists and search terms from articles and abstracts. The latter types have been thoroughly computerized and covered in the literature. Use of the computer as an aid to traditional book-indexing, however, has received little attention. In a previously reported project, a general-purpose textediting interactive system, wylbur, was used to aid human indexing of the collected issues of a technical journal. In the light of previous experience, we designed a language, mag-net, for support of indexing. The code was written in rmag. The language was designed for ease of syntactical debugging and of explanation, without use of special keys, rockers, or light pens.
N1  - Accession Number: ISTA0903184; Kuch, T D C 1; Magnuson, Robert; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.;  Source Info: 1974; Note: Update Code: 0900; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chafetz, M. E.;
T1  - Alcoholism: drug dependency problem number one
CT  - Alcoholism: drug dependency problem number one
JO  - Journal of Drug Issues (USA)
JF  - Journal of Drug Issues (USA)
Y1  - 1974/01/01/
VL  - 4
IS  - Jan
SP  - 64
EP  - 68
SN  - 00220426
AD  - Director, National Institute on Alcohol Abuse and Alcoholism, Department of Health, Education, and Welfare, Washington, D.C.
N1  - Accession Number: 11-3444; Language: English; Journal Coden: JDGIA6; Section Heading: Sociology, Economics and Ethics; Abstract Author: Pamela N. Davis
N2  - Some major programs and issues of the federal alcoholism effort are discussed, and the role of alcoholism programs in the nation's efforts to solve this problem is considered.
KW  - Alcoholism--therapy--programs, federal, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Levis, William R.
AU  - Whalen, John J.
AU  - Miller, A. Edgar
AU  - Jr.
T1  - STUDIES ON THE CONTACT SENSITIZATION OF MAN WITH SIMPLE CHEMICALS II. Lymphokine Production in Allergic Contact Dermatitis to Dinitrochlorobenzene.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1974/01//
VL  - 62
IS  - 1
M3  - Article
SP  - 2
EP  - 6
SN  - 0022202X
AB  - A cell-free soluble factor(s) was specifically generated in primary leukocyte cultures during interaction of lymphocytes from a dinitrochlorobenzene (DNCB)-sensitized subject with DNCB-erythrocyte complexes (DNCB-antigen). The factor(s) was capable of inducing blastogenesis and DNA synthesis in secondary autologous DNCB-sensitive leukocyte cultures and in leukocyte cultures of allogeneic subjects who had not been sensitized to DNCB. Under the culture conditions employed to generate the factor(s), maximal DNA synthesis was induced in secondary "insensitive" cultures by supernates collected after 1-3 days of primary culture. Higher concentrations of primary stimulated culture supernates induced greater degrees of DNA synthesis in secondary "insensitive" leukocyte cultures with instances of greater than 100-fold stimulation. The discovery of lymphokine activity in experimentally induced allergic contact dermatitis offers a new and advantageous approach for investigating the biologic significance of these substances and may assist in better understanding cell-mediated immunity and the relationship of allergic contact dermatitis to other forms of delayed type hypersensitivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSFER factor (Immunology)
KW  - LYMPHOKINES
KW  - DNA
KW  - LEUCOCYTES
KW  - BLASTOGENESIS (Embryology)
KW  - IMMUNITY
KW  - ALLERGY
N1  - Accession Number: 12676706; Levis, William R. 1 Whalen, John J. 1 Miller, A. Edgar Jr. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health. Bethesda. Maryland 20014.; Source Info: Jan1974, Vol. 62 Issue 1, p2; Subject Term: TRANSFER factor (Immunology); Subject Term: LYMPHOKINES; Subject Term: DNA; Subject Term: LEUCOCYTES; Subject Term: BLASTOGENESIS (Embryology); Subject Term: IMMUNITY; Subject Term: ALLERGY; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12676706
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12676706&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Clarke, Robert F
T1  - Catalog card produced bibliographies
JO  - Special Libraries
JF  - Special Libraries
Y1  - 1974/01//
VL  - 65
IS  - 1
M3  - Article
SP  - 26
EP  - 27
SN  - 00386723
AB  - Removing cards temporarily from the card catalog and photocopying them serves as a quick, efficient means to produce typographically error free bibliographies which require no proofreading or correcting. This practical resulted in a 15% reduction in bibliography compilation time and a 97% reduction in clerical time.
N1  - Accession Number: ISTA0900911; Clarke, Robert F 1; Affiliations: 1 : National Institutes Of Health Library, Bethesda, Maryland.;  Source Info: January 1974, Vol. 65 Issue 1, p26; Note: Update Code: 0900; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2013-41576-010
AN  - 2013-41576-010
AU  - Mannino, Fortune V.
AU  - Shore, Milton F.
T1  - Family structure, aftercare, and post-hospital adjustment.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1974/01//
VL  - 44
IS  - 1
SP  - 76
EP  - 85
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Mannino, Fortune V., Mental Health Study Center, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-41576-010. PMID: 4358590 Partial author list: First Author & Affiliation: Mannino, Fortune V.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aftercare; Family Structure; Program Development; Treatment Outcomes. Minor Descriptor: Adjustment; Hospitals; Innovation. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Katz Scale; KAS Form RS 4 Level of Freetime Activities; KAS Form S2 Level of Performance of Socially Expected Activities; Social Adequacy Rating Scale of Pinchak and Rollins. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan, 1974. 
AB  - This follow-up study of an innovative aftercare program compares a group of former patients who participated with a control group; explores the effects of family structure and sex on post-hospital adjustment; and evaluates the relationship of family structure to treatment outcome. Results replicate previous findings that have shown an association between family structure and post-hospital adjustment. Findings confirm the importance of family variables in analyzing program effectiveness, as well as in program planning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - family structure
KW  - innovative aftercare programs
KW  - post hospital adjustment
KW  - program planning
KW  - treatment outcome
KW  - 1974
KW  - Aftercare
KW  - Family Structure
KW  - Program Development
KW  - Treatment Outcomes
KW  - Adjustment
KW  - Hospitals
KW  - Innovation
KW  - 1974
DO  - 10.1111/j.1939-0025.1974.tb00871.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41576-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41576-019
AN  - 2013-41576-019
AU  - Shore, Milton F.
T1  - Review of Mental health: From infancy through adolescence; The mental health of children: Services, research and manpower; and Social change and the mental health of children.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1974/01//
VL  - 44
IS  - 1
SP  - 159
EP  - 162
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-41576-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Child Care; Mental Health Programs; Personnel Supply; Social Change. Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: No authorship indicated. Mental health: From infancy through adolescence=Joint Commission on Mental Health of Children: Report of Task Forces I, II, and Ill, and the Committees on Education and Rehg1on. 470 pp. $15.00. Harper & Row, New York; 1973. No authorship indicated. The mental health of children: Services, research and manpower=Joint Commission on the Mental Health of Children: Report of Task Forces IV and V, and the Report of the Committee on Clinical Issues. 446 pp. $15.00. Harper & Row, New York; 1973. No authorship indicated. Social change and the mental health of children=Joint Commission on the Mental Health of Children: Report of Task Force VI, and Excerpts from the Report of the Committee on Children of Minority Groups. 225 pp. $8.50. Harper & Row, New York; 1973. References Available: Y. Page Count: 4. Issue Publication Date: Jan, 1974. 
AB  - Reviews the books, Mental Health: From Infancy through Adolescence (see record [rid]1973-31768-000[/rid]); The Mental Health of Children: Services, Research and Manpower (see record [rid]1973-31770-000[/rid]); and Social Change and the Mental Health of Children (see record [rid]1973-31769-000[/rid]). The three volumes of task force and committee reports under review clearly show the difficulty in dividing the area of child mental health for study. There is no doubt that the volumes of the Joint Commission on the Mental Health of Children are extraordinarily comprehensive documents with masses of substantive data, reflecting the current knowledge in the field of the mental health of children as seen by major experts in the field. One can criticize the style and the approach. One can fault it for lack of focus. One can wish priorities were more carefully spelled out. One can disagree with the approaches and take sides as to whether the report should have had a better balance of the clinical and the social, with more emphasis on the services needed for the mentally ill child and his family. In an atmosphere characterized by a deep concern for the welfare of children and youth and support for the free exchange of ideas, the most viable proposals are often identified and nurtured, while others wither and die. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - children services
KW  - child mental health research
KW  - manpower
KW  - social change
KW  - 1974
KW  - Child Care
KW  - Mental Health Programs
KW  - Personnel Supply
KW  - Social Change
KW  - 1974
U2  - No authorship indicated. (1973); Mental health: From infancy through adolescence; Joint Commission on Mental Health of Children: Report of Task Forces I, II, and Ill, and the Committees on Education and Rehg1on. 470 pp. $15.00. Harper & Row, New York
U2  - No authorship indicated. (1973); The mental health of children: Services, research and manpower; Joint Commission on the Mental Health of Children: Report of Task Forces IV and V, and the Report of the Committee on Clinical Issues. 446 pp. $15.00. Harper & Row, New York
U2  - No authorship indicated. (1973); Social change and the mental health of children; Joint Commission on the Mental Health of Children: Report of Task Force VI, and Excerpts from the Report of the Committee on Children of Minority Groups. 225 pp. $8.50. Harper & Row, New York
DO  - 10.1111/j.1939-0025.1974.tb00880.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - DALE, DAVID C.
AU  - GRAW JR., ROBERT G.
T1  - Transplantation of Allogeneic Bone Marrow in Canine Cyclic Neutropenia.
JO  - Science
JF  - Science
Y1  - 1974/01/11/
VL  - 183
IS  - 4120
M3  - Article
SP  - 83
EP  - 84
SN  - 00368075
AB  - Transplantation of normal bone marrow cells to a gray collie dog with cyclic neutropenia resulted in normal granulocytopoiesis. The finding suggests that cyclic neutropenia occurs because the hematopoietic stem cells are defective. Because of the similarity of human and canine cyclic neutropenia, it also suggests that the human disease may be curable by marrow transplantation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85344890; DALE, DAVID C. 1; GRAW JR., ROBERT G. 2; Affiliations: 1: Laboratory of Clinical Investigation, National Institute-of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Experimental Hematology Section, Pediatric Oncology Branch. National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/11/1974, Vol. 183 Issue 4120, p83; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BENSINGER, RICHARD E.
AU  - FLETCHER, R. THEODORE
AU  - CHADER, GERALD J.
T1  - Guanylate Cyclase: Inhibition by Light in Retinal Photoreceptors.
JO  - Science
JF  - Science
Y1  - 1974/01/11/
VL  - 183
IS  - 4120
M3  - Article
SP  - 86
EP  - 87
SN  - 00368075
AB  - Guanylate cyclase activity of retinal rod outer segments was measured by an assay procedure that minimizes the technical problems caused by the high activity of cyclic nucleotide phosphodiesterase in neural tissue. Cyclase activity in rods is significantly higher than in brain. Moreover, activity is twofold higher in dark-adapted rods than in light-bleached rods, a sensitivity that is lost when the preparation is treated with detergent. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85344892; BENSINGER, RICHARD E. 1,2; FLETCHER, R. THEODORE 1; CHADER, GERALD J. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 2: Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110; Issue Info: 1/11/1974, Vol. 183 Issue 4120, p86; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHO-CHUNG, YOON SANG
AU  - GULLINO, PIETRO M.
T1  - In vivo Inhibition of Growth of Two Hormone-Dependent Mammary Tumors by Dibutyryl Cyclic AMP.
JO  - Science
JF  - Science
Y1  - 1974/01/11/
VL  - 183
IS  - 4120
M3  - Article
SP  - 87
EP  - 88
SN  - 00368075
AB  - Growth of hormone-dependent rat mammary tumors was arrested in vivo by N6,O²'-dibutyryl cyclic adenosine 3',5'-monophosphate. Estrogen concentration did not change, but acid ribonuclease activity and synthesis increased during treatment with the dibutyryl cyclic nucleotide, as was shown during tumor regression due to hormonal deprivation. Growth arrest, thus, appears to derive from enhanced tissue catabolism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85344893; CHO-CHUNG, YOON SANG 1; GULLINO, PIETRO M. 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/11/1974, Vol. 183 Issue 4120, p87; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROSS, PHILIP D.
T1  - NMicrocalorimetry Techniques: Applications to Cellular Systems.
JO  - Science
JF  - Science
Y1  - 1974/01/18/
VL  - 183
IS  - 4121
M3  - Article
SP  - 225
EP  - 225
SN  - 00368075
N1  - Accession Number: 85344944; ROSS, PHILIP D. 1; Affiliations: 1: Laboratory of Molecular Biology, National Institute of Arthritis, Aletabolismn, and Digestive Diseeases, National Institutes of Health, Bethesda. Marvland 200714; Issue Info: 1/18/1974, Vol. 183 Issue 4121, p225; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Raskin, A.;
T1  - Guide for drug use in depressive disorders
CT  - Guide for drug use in depressive disorders
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1974/02/01/
VL  - 131
IS  - Feb
SP  - 181
EP  - 185
SN  - 0002953X
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Lane, Rockville, Maryland 20852
N1  - Accession Number: 12-0303; Language: English; Chemical Name: Imipramine--50-49-7 Chlorpromazine--50-53-3 Diazepam--439-14-5 Phenelzine--51-71-8; References: 42; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: C. Robert Sturwold
N2  - During a 7-week study involving 880 moderate to severe depressed patients, psychotropic medications were examined for their selective effects on the major symptoms of depression. The following median daily doses of antidepressants were administered: imipramine, 300 mg. (200 patients); chlorpromazine, 600 mg. (176 patients) diazepam, 30 mg. (104 patients); phenelzine, 45 mg. (110 patients); and placebo (290 patients). Evalutations were made at the end of 1, 2, 3, 5, and 7 weeks. Thirty-six percent of the patients receiving placebo and 44% of the patients receiving active agents showed improvement after 3 weeks. Guidelines were suggested for the treatment of the major symptoms of depression and it was noted that for many patients, depression is a self-limiting illness with a high spontaneous recovery and high placebo response.
KW  - Imipramine--depression-;
KW  - Chlorpromazine--depression-;
KW  - Diazepam--depression-;
KW  - Phenelzine--depression-;
KW  - Psychotherapeutic agents--depression--therapy, guidelines, in patients;
KW  - Guidelines--psychotherapeutic agents--depression, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Schneiderman, Marvin A.
T1  - DESEGREGATING HEALTH STATISTICS.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1974/02//
VL  - 64
IS  - 2
M3  - Letter
SP  - 98
EP  - 172
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "Desegregating Health Statistics," by Milton Terris in the June 1973 issue.
KW  - Letters to the editor
KW  - Medical statistics
N1  - Accession Number: 14093953; Schneiderman, Marvin A. 1; Affiliations: 1: Associate Director for Field, Studies and Statistics, DCCP National Cancer Institute, Bethesda, MD; Issue Info: Feb1974, Vol. 64 Issue 2, p98; Subject Term: Letters to the editor; Subject Term: Medical statistics; Number of Pages: 4p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Post, R. M.;
AU  - Goodwin, F. K.;
T1  - Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients
CT  - Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/02/01/
VL  - 30
IS  - Feb
SP  - 234
EP  - 239
AD  - 3-West Unit, Adult Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 11-4468; Language: English; Trade Name: Presamine--Tofranil--Elavil; Generic Name: Imipramine; Imipramine; Amitriptyline; Chemical Name: Amitriptyline--50-48-6 Imipramine--50-49-7; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants amitriptyline (28:16.04); AHFS Class: Antidepressants imipramine; References: 58; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - Ten depressed patients who received amitriptyline (Elavil) or imipramine (Presamine; Tofranil) at doses ranging from 150 to 350 mg./day for an average of 25 days had lower levels of 5-hydroxyindoleacetic acid, a serotonin metabolite, in the cerebrospinal fluid (CSF) when compared to values obtained from untreated patients. Both drugs reduced the base line levels and the probenecid-induced accumulations of 5-hydroxyindoleacetic acid in the CSF of depressed patients but did not affect the accumulation of homovanillic acid, metabolite of brain dopamine. Probenecid given in divided doses for a total of 100 mg./kg. caused a rapid accumulation of CNS neurotransmitter metabolites by inhibiting transport out of the CNS. It was suggested that tricyclic antidepressants reduce the CNS serotonin turnover.
KW  - Amitriptyline--mechanism of action-;
KW  - Imipramine--mechanism of action-;
KW  - Antidepressants--amitriptyline--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
KW  - Antidepressants--imipramine--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
KW  - Mechanism of action--amitriptyline--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
KW  - Mechanism of action--imipramine--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - McDonald, Henry
T1  - Implanting Human Values into Genetic Control.
JO  - Bulletin of the Atomic Scientists
JF  - Bulletin of the Atomic Scientists
Y1  - 1974/02//
VL  - 30
IS  - 2
M3  - Article
SP  - 21
EP  - 22
PB  - Bulletin of the Atomic Scientists
SN  - 00963402
N1  - Accession Number: 21570026; McDonald, Henry 1; Affiliation:  1: Technical Information Specialist, National Cancer Institute, National Institutes of Health; Source Info: Feb1974, Vol. 30 Issue 2, p21; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeFranzo, R. A.;
AU  - Colvin, O. M.;
AU  - Braine, H.;
AU  - Robertson, G. L.;
AU  - Davis, P. J.;
T1  - Cyclophosphamide and the kidney
CT  - Cyclophosphamide and the kidney
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1974/02/01/
VL  - 33
IS  - Feb
SP  - 483
EP  - 491
AD  - Metabolism Section, Clinical Physiology Branch, Geronotology Research Center, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland
N1  - Accession Number: 12-5056; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 20; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology
N2  - The effect of cyclophosphamide on renal function was studied in 17 normally hydrated patients with cancer. No nephrotoxic effects were observed. Doses of cyclophosphamide over 50 mg/kg did, however, impair water excretion as manifested by weight gain, hyponatremia, and inappropriately concentrated urine. The decrease in serum osmolarity (range 6-12 mOsm/l) and increase in urine osmolarity (range 305-798 mOsm/l) occurred 4-12 hr after cyclophosphamide administration, lasted 20-24 hr, and correlated temporally with the urinary excretion of cyclophosphamide alkylatine metabolites. No change in creatinine clearance or urinary excretion of protein, sodium, potassium, calcium, phosphorus, uric acid, and amino acids was observed after cyclophosphamide.
KW  - Cyclophosphamide--toxicity-;
KW  - Antineoplastic agents--cyclophosphamide--toxicity, lack, renal, in cancer patients;
KW  - Excretion--cyclophosphamide--and lack of renal toxicity, in patients;
KW  - Metabolism--cyclophosphamide--excretion, lack of renal toxicity, in patients;
KW  - Toxicity--cyclophosphamide--lack, renal, in cancer patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bryan, J. H.;
AU  - Henderson, E. S.;
AU  - Leventhal, B. G.;
T1  - Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia
CT  - Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1974/02/01/
VL  - 33
IS  - Feb
SP  - 539
EP  - 544
AD  - Bldg. 10, Room 3B-06, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-4658; Language: English; Chemical Name: Cytarabine--147-94-4 Thioguanine--154-42-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cytarabine and thioguanine (10:00); AHFS Class: Antineoplastic agents thioguanine and cytarabine; References: 17; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The efficacy of the combination of 100 mg/m\SU/2\BS/ IV or SC cytosine arabinoside (cytarabine) with 75-100 mg/m\SU/2\BS/ oral thioguanine was tested in 19 children with acute lymphocytic leukemia. Duration of therapy was variable, depending on patient response. Complete remissions were obtained in 9 patients. Severe marrow hypoplasia and pancytopenia were the most common side effects, along with mild nausea, vomiting, and minimally abnormal liver function tests.
KW  - Cytarabine--and thioguanine-;
KW  - Thioguanine--and cytarabine-;
KW  - Antineoplastic agents--cytarabine and thioguanine--leukemias, acute lymphocytic, evaluation, in children;
KW  - Combined therapy--cytarabine and thioguanine--leukemias, acute lymphocytic, evaluation, in children;
KW  - Combined therapy--thioguanine and cytarabine--leukemias, acute lymphocytic, evaluation, in children;
KW  - Antineoplastic agents--thioguanine and cytarabine--leukemias, acute lymphocytic, evaluation, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - De Bracco, Maria M. E.
AU  - Windhorst, Dorothy
AU  - Stroud, R. M.
AU  - Moncada, B.
T1  - THE AUTOSOMAL RECESSIVE MODE OF INHERITANCE OF C1r DEFICIENCY IN A LARGE PUERTO RICAN FAMILY.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1974/02//
VL  - 16
IS  - 2
M3  - Article
SP  - 183
EP  - 188
PB  - Wiley-Blackwell
SN  - 00099104
AB  - All living members of three generations of a large family with Clr deficiency were studied. The two index cases showed undetectable CIr and partial deficiency of Cls associated with cutaneous, renal and joint disease as described previously (Moncada et al, 1972). The quantitative Clq, Cl rand Cls studies on the parents and the normal siblings were consistent with an autosomal recessive mode of inheritance for the Clr trait. There was more correlation of the Clr levels with the Cls levels than with the CIq levels, compatible with a linkage of the synthesis or catabolism of Cls with Clr. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - METABOLISM
KW  - DEFICIENCY diseases
KW  - FAMILIES
KW  - GENERATIONS
KW  - PARENTS
KW  - HEALTH
N1  - Accession Number: 16223807; De Bracco, Maria M. E. 1 Windhorst, Dorothy 2 Stroud, R. M. 1 Moncada, B. 3,4; Affiliation:  1: Instituto de Investigaciones Medicas, Universidad de Buenos Aires, Buenos Aires, Argentina  2: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 2004, U.S.A.  3: Division of Dermatology, University of Chicago, Chicago, Illinois  4: Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, University Station, Birmingham, Alabama 35294, U.S.A.; Source Info: Feb1974, Vol. 16 Issue 2, p183; Subject Term: METABOLISM; Subject Term: DEFICIENCY diseases; Subject Term: FAMILIES; Subject Term: GENERATIONS; Subject Term: PARENTS; Subject Term: HEALTH; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Nutt, J. G.;
AU  - Jusinski, D. R.;
T1  - Methadone-naloxone mixtures for use in methadone maintenance programs. 1. An evaluation in man of their pharmacological feasibility. 2. Demonstration of acute physical dependence
CT  - Methadone-naloxone mixtures for use in methadone maintenance programs. 1. An evaluation in man of their pharmacological feasibility. 2. Demonstration of acute physical dependence
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1974/02/01/
VL  - 15
IS  - Feb
SP  - 156
EP  - 166
SN  - 00099236
AD  - National Institute on Drug Abuse Addiction Research Center, U. S. Dept. of H. E. W., Alcohol, Drug Abuse, and Mental Health Administration, Lexington, Kentucky
N1  - Accession Number: 12-6143; Language: English; Chemical Name: Naloxone--465-65-6 Methadone--76-99-3; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Mixtures of methadone (I) and naloxone (II) were substituted for the I dispensed in methadone maintenance programs to reduce diversion for purposes of abuse. By the oral route in nondependent subjects I-II mixtures are indistinguishable from I alone. By the IV route, the mixtures have significantly less miotic, behavioral and subjective effects than I alone. Administration of I-II to morphine dependent subjects ameliorates but does not abolish the abstinence precipitated by II. II 10 mg administered orally does not precipitate abstinence in morphine dependent subjects, and doses of 15 and 30 mg produce only mild signs of abstinence. It was concluded that I-II mixtures could be compounded that would be interchangeable with I intended for oral consumption, but have less parenteral abuse liability than I. The observation that 4 mg IV naloxone precipitated signs of abstinence one week after a single dose of I indicated the development of acute physical dependence on I.
KW  - Naloxone--combination, methadone-;
KW  - Methadone--combination, naloxone-;
KW  - Narcotic antagonists--naloxone, combination, methadone--reduction, IV abuse potential, in methadone maintenance patients;
KW  - Drug abuse--methadone--reduction, combined with naloxone, in patients;
KW  - Dependence--methadone--reduction, abuse potential, combined with naloxone, in patients;
KW  - Drug administration--routes--effects, methadone-naloxone combination, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Corfman, P. A.;
T1  - Coordinated studies of the effects of oral contraceptives
CT  - Coordinated studies of the effects of oral contraceptives
JO  - Contraception (USA)
JF  - Contraception (USA)
Y1  - 1974/02/01/
VL  - 9
IS  - Feb
SP  - 109
EP  - 122
SN  - 00107824
AD  - National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-4110; Language: English; References: 13; Journal Coden: CCPTAY; Human Indicator: Yes; Section Heading: Toxicity
N2  - The data obtained from a national program on the medical effects of oral contraceptives are reported. The study confirms previous data which relates oral contraceptive use with increased risk of thromboembolism. A retrospective study shows increased risk of stroke with users. Retrospective studies also show no increased risk of breast cancer at this time. It was also noted that there has been a significant change in American contraceptive practice with the use of oral contraceptives increasing by 10% between 1965 and 1970. A selected list of disorders implicated with oral contraceptives includes: thromboembolism, stroke, breast and cervical cancer, decreased carbohydrate tolerance, increased plasma lipids, impaired liver function, jaundice and increased blood pressure.
KW  - Toxicity--contraceptives, oral--studies, national, U.S., in women;
KW  - Contraceptives, oral--toxicity--studies, national, U.S., in women;
KW  - Statistics--contraceptives, oral--toxicity, studies, national, U.S., in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Altman, L. C.
AU  - Kirchner, H.
T1  - Mononuclear Leucocyte Chemotaxis in the Chicken. DEFINITION OF A PHYLOGENETICALLY SPECIFIC LYMPHOKINE.
JO  - Immunology
JF  - Immunology
Y1  - 1974/02//
VL  - 26
IS  - 2
M3  - Article
SP  - 393
EP  - 405
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Chicken leucocytes when stimulated in vitro with purified protein derivative (PPD), a specific antigen or concanavalin A (Con A), a nonspecific mitogen, produced a soluble factor which was chemotactic for homologous monocytes. The production of this factor, by PPD-stimulated spleen cells from PPD-immunized chickens was found to be a correlate of delayed skin reactivity. Leucocytes from the blood, spleen and thymus of chickens produced measurable amounts of mononuclear leucocyte chemotactic factor (MNL CTX); however, bursal lymphocytes failed to synthesize this mediator. Chicken MNL CTX was heat stable (56° for 30 minutes), nondialysable. remained active if frozen and thawed, and had an estimated molecular weight of 12,500 as determined by molecular sieve chromatography and sucrose density ultracentrifugation. Moreover, this lympho- kine was sensitive to treatment with pepsin and trypsin but not with neuraminidase. These results indicate that chicken MNL CTX is a protein whose activity is independent of sialic acid. The physical characteristics of chicken MNL CTX are remarkably similar to those of a chemotactic lymphokine recently defined in man. However, chicken MNL CTX was not active in attracting human, guinea-pig or rabbit MNL, and chicken MNL failed to migrate in response to human or guinea- pig lymphokine CTX. These findings indicate that MNL CTX is a lymphokine whose activity is phylogenetically restricted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOID tissue
KW  - BLOOD cells
KW  - DIGESTIVE enzymes
KW  - ENDOCRINE glands
KW  - CHROMATOGRAPHIC analysis
KW  - PANCREATIC secretions
N1  - Accession Number: 12827484; Altman, L. C. 1 Kirchner, H. 1; Affiliation:  1: Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Feb74, Vol. 26 Issue 2, p393; Subject Term: LYMPHOID tissue; Subject Term: BLOOD cells; Subject Term: DIGESTIVE enzymes; Subject Term: ENDOCRINE glands; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: PANCREATIC secretions; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KREUZ, DAVID S.
AU  - AXELROD, JULIUS
T1  - Amphetamine in Human Plasma: A Sensitive and Specific Enzymatic Assay.
JO  - Science
JF  - Science
Y1  - 1974/02//2/ 1/1974
VL  - 183
IS  - 4123
M3  - Article
SP  - 420
EP  - 421
SN  - 00368075
AB  - A sensitive and specific enzymatc-isotopic method of determining plasma amphetamine concentrations in man is described. The assay is based on the transfer of the tritiated methyl group of S-adenosyl-L-[methyl-³H]methionine to amphetamine in the presence of a partially purified N-methyltransferase from rabbit lung. With this assay as little as 10 nanograms of amphetamine per milliliter of plasma can be accurately determined. The concentrations of d- and 1-amphetamine in the plasma after 20 to 30 milligrams of the drug had been ingested by human subjects are reported. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85344977; KREUZ, DAVID S. 1; AXELROD, JULIUS 2; Affiliations: 1: Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/ 1/1974, Vol. 183 Issue 4123, p420; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - AARONSON, STUART A.
AU  - DUNN, CLAIRE Y.
T1  - High-Frequency C-Type Virus Induction by Inhibitors of Protein Synthesis.
JO  - Science
JF  - Science
Y1  - 1974/02//2/ 1/1974
VL  - 183
IS  - 4123
M3  - Article
SP  - 422
EP  - 424
SN  - 00368075
AB  - When inhibitors of protein synthesis are added to BALBIc mouse cells in clulture, induction of naturally integrated C-type RNA virus occuls in a high percentage of cells. The action of protein synthesis inhibitors difters fromn that of halogenated pyrimidines, another class of virlus induicers, in their effects on biologically distinguishable virluses. The luse of sutch inhibitors to stludy integrated virus expression provides a means for studying gene reglulation in mammalian cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85344978; AARONSON, STUART A. 1; DUNN, CLAIRE Y. 2; Affiliations: 1: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Hazleton Laboratories, Inc., Vienna, Virginia 22180; Issue Info: 2/ 1/1974, Vol. 183 Issue 4123, p422; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06259-037
AN  - 2006-06259-037
AU  - Stierlin, Helm
T1  - A Forced Awakening from Psychosis.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1974/02//
VL  - 19
IS  - 2
SP  - 131
EP  - 132
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06259-037. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Stierlin, Helm; Family Studies Section, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Mental Disorders; Schizophrenia; Treatment. Classification: Psychological Disorders (3210); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Honig, Albert M. The Awakening Nightmare: A Breakthrough in Treating the Mentally Ill=Rockaway, N.J.: American Faculty Press, 1972. Pp. xi + 303. $9.95 cloth; $2.65 paper; 1972. Page Count: 2. Issue Publication Date: Feb, 1974. 
AB  - Reviews the book, The Awakening Nightmare: A Breakthrough in Treating the Mentally Ill by Albert M. Honig (see record [rid]1974-01658-000[/rid]). The book elaborates the philosophy, view of mental illness, and therapeutic principles that guide the author. Rather than giving a systematic exposition, the book brings together a number of essays, some of which appeared as journal articles. However much one might disagree with aspects of author's philosophy or therapeutic approach, the fact remains that he has broken new ground where many others did not dare to tread. The author comes across as a strong therapeutic personality who can bring down to earth and back to reality even deeply and chronically disturbed schizophrenics. Anyone engaged in the long-term, intensive therapy of these patients will appreciate what this means. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental illness
KW  - schizophrenia
KW  - treatment
KW  - 1974
KW  - Mental Disorders
KW  - Schizophrenia
KW  - Treatment
KW  - 1974
U2  - Honig, Albert M. (1972); The Awakening Nightmare: A Breakthrough in Treating the Mentally Ill; Rockaway, N.J.: American Faculty Press, 1972. Pp. xi + 303. $9.95 cloth; $2.65 paper
DO  - 10.1037/0012467
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bennett, J. E.;
T1  - Chemotherapy of systemic mycoses. Part II
CT  - Chemotherapy of systemic mycoses. Part II
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/02/07/
VL  - 290
IS  - Feb 7
SP  - 320
EP  - 323
SN  - 00284793
AD  - Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-3233; Language: English; Trade Name: Bay-b-5097--5-Fluorocytosine; Generic Name: Clotrimazole; Flucytosine; Chemical Name: Flucytosine--2022-85-7 Clotrimazole--23593-75-1; Therapeutic Class: (8:12.04); AHFS Class: Fungicides flucytosine (8:12.04); AHFS Class: Fungicides clotrimazole; References: 105; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2  - 5-Fluorocytosine (flucytosine; 5-FC) is discussed in regard to susceptibility, mechanism of action, experimental infections, clinical trials and adverse reactions when used to treat systemic mycoses. Also discussed are clotrimazole (Bay-b-5097), 2-hydroxystilbamidine and iodide.
KW  - Flucytosine--mycoses-;
KW  - Clotrimazole--mycoses-;
KW  - Hydroxystilbamidine--mycoses-;
KW  - Iodides--mycoses--systemic, therapy, in patients;
KW  - Fungicides--flucytosine--mycoses, systemic, therapy, in patients;
KW  - Fungicides--clotrimazole--mycoses, systemic, therapy, in patients;
KW  - Fungicides--hydroxystilbamadine--mycoses, systemic, therapy, in patients;
KW  - Fungicides--iodides--mycoses, systemic, therapy, in patients;
KW  - Toxicity--flucytosine--side effects, mycoses, systemic, therapy, in patients;
KW  - Mechanism of action--flucytosine--mycoses, systemic, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kashket, Eva Ruth
AU  - Robbins, Mary Louise
AU  - Leive, Loretta
AU  - Huang, Alice S.
T1  - Status of Women Microbiologists.
JO  - Science
JF  - Science
Y1  - 1974/02/08/
VL  - 183
IS  - 4124
M3  - Article
SP  - 488
EP  - 494
SN  - 00368075
N1  - Accession Number: 85345002; Kashket, Eva Ruth 1; Robbins, Mary Louise 2; Leive, Loretta 3; Huang, Alice S. 4; Affiliations: 1: Principal associate, department of physiology, Harvard Medical School, Boston, Massachusetts 02115; 2: Professor of microbiology, George Washington University Medical Center, Washington, D.C. 20005; 3: Research biologist, Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolic, Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 4: Associate professor of microbiology and molecular genetics, Harvard Medical School; Issue Info: 2/ 8/1974, Vol. 183 Issue 4124, p488; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GARELIS, E.
AU  - NEFF, N. H.
T1  - Cyclic Adenosine Monophosphate: Selective Increase in Caudate Nucleus after Administration of L-Dopa.
JO  - Science
JF  - Science
Y1  - 1974/02/08/
VL  - 183
IS  - 4124
M3  - Article
SP  - 532
EP  - 533
SN  - 00368075
AB  - Treatment with the dopamine precursor L-dopa produced a significant accumulation of adenosine 3',S'-monophosphate (cyclic AMP) in the caudate nucleus of the rat. In contrast, there was no change in the amount of cyclic AMP in the cerebellum. Accumulation of cyclic AMP in the caudate nucleus after administration of L-dopa was prevented by prior treatment with the decarboxylase inhibitor RO 4-4602. These observations and those in other laboratories support the assumption that dopainine formed from L-dopa selectively activates striatal adenylate cyclase. The in vivo activation of adenylate cyclase after treatment with L-dopa may be a useful model for studying neurological and psychiatric disorders that are thought to involve the dopaminergic system of the brain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345030; GARELIS, E. 1; NEFF, N. H. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/ 8/1974, Vol. 183 Issue 4124, p532; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PERRIN, CHARLES L.
AU  - TING, KAI-LI H.
T1  - Testing of Computer-Assisted Methods for Classification of Pharmacological Activity.
JO  - Science
JF  - Science
Y1  - 1974/02/08/
VL  - 183
IS  - 4124
M3  - Article
SP  - 551
EP  - 552
SN  - 00368075
N1  - Accession Number: 85345040; PERRIN, CHARLES L. 1; TING, KAI-LI H. 2; Affiliations: 1: Institute of Neurobiology, Göteborg University, Göteborg, Sweden; 2: Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 8/1974, Vol. 183 Issue 4124, p551; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Canellos, G. P.;
AU  - DeVita, V. T.;
AU  - Gold, G. L.;
AU  - Chabner, B. A.;
AU  - Schein, P. S.;
AU  - \ET/;
T1  - Cyclical combination chemotherapy for advanced breast carcinoma
CT  - Cyclical combination chemotherapy for advanced breast carcinoma
JO  - British Medical Journal (England)
JF  - British Medical Journal (England)
Y1  - 1974/02/09/
VL  - 1
IS  - Feb 9
SP  - 218
EP  - 220
SN  - 09598146
AD  - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-3262; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Fluorouracil--51-21-8 Methotrexate--59-05-2 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide, fluorouracil, methotrexate and prednisone (10:00); AHFS Class: Antineoplastic agents fluorouracil, cyclophosphamide, methotrexate and prednisone (10:00); AHFS Class: Antineoplastic agents methotrexate, cyclophosphamide, fluorouracil and prednisone (10:00); AHFS Class: Antineoplastic agents prednisone, cyclophosphamide, fluorouracil and methotrexate; References: 10; Journal Coden: BMJOAE; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Twenty-five patients with advanced metastatic breast cancer were treated with the combination of methotrexate 60 mg./sq.m. and 5-fluorouracil 700 mg./sq.m. I.V. on the first and eighth days, and cyclophosphamide 100 mg./sq.m. and prednisone 40 mg./sq.m. by mouth daily for the first 14 days of a 28-day cycle. The patients had had no previous chemotherapy or extensive radiotherapy and all but 2 had not responded to hormonal therapy or endocrine ablation. The major metastatic lesions were: lung (12 patients), liver (4 patients), bone (4 patients), soft tissue (3 patients), nodes (2 patients). Seventeen of the 25 patients (68%) responded to treatment with 7 complete remissions; these included patients suffering metastatic lesions in the lung, nodes, and soft tissue. The overall median duration of response was 9 months (range 6-26 months). Toxicity was primarily hematological, but the group received an average of at least 75% of their calculated dose for each monthly cycle. Hematological toxicity was most pronounced in patients with liver dysfunction and bone marrow involvement. Out of 8 nonresponders 7 died, with a median survival of 6 months. Only 6 of 17 responders died, and the median survival in this group will exceed 13 months. There was no correlation between the length of the metastasis-free interval after previous treatment and subsequent response to chemotherapy.
KW  - Cyclophosphamide--fluorouracil, methotrexate and prednisone-;
KW  - Fluorouracil--cyclophosphamide, methotrexate and prednisone-;
KW  - Methotrexate--cyclophosphamide, fluorouracil and prednisone-;
KW  - Prednisone--cyclophosphamide, fluorouracil and methotrexate-;
KW  - Combined therapy--cyclophosphamide, fluorouracil, methotrexate and prednisone--cyclical, advanced breast carcinomas, in patients;
KW  - Combined therapy--fluorouracil, cyclophosphamide, methotrexate and prednisone--cyclical, advanced breast carcinomas, in patients;
KW  - Combined therapy--methotrexate, cyclophosphamide, fluorouracil and prednisone--cyclical, advanced breast carcinomas, in patients;
KW  - Combined therapy--prednisone, cyclophosphamide, fluorouracil and methotrexate--cyclical, advanced breast carcinomas, in patients;
KW  - Antineoplastic agents--cyclophosphamide, fluorouracil, methotrexate and prednisone--combined therapy, cyclical, advanced breast carcinoma, in patients;
KW  - Antineoplastic agents--fluorouracil, cyclophosphamide, methotrexate and prednisone--combined therapy, cyclical, advanced breast carcinoma, in patients;
KW  - Antineoplastic agents--methotrexate, cyclophosphamide, fluorouracil and prednisone--combined therapy, cyclical, advanced breast carcinoma, in patients;
KW  - Antineoplastic agents--prednisone, cyclophosphamide, fluorouracil and methotrexate--combined therapy, cyclical, advanced breast carcinoma, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - FRIEDMAN, THOMAS B.
AU  - YARKIN, RHODA J.
AU  - MERRIL, CARL R.
T1  - Galactosemia and Galactonolactone: Further Biochemical Observations.
JO  - Science
JF  - Science
Y1  - 1974/02/22/
VL  - 183
IS  - 4126
M3  - Article
SP  - 764
EP  - 766
SN  - 00368075
N1  - Accession Number: 85345112; FRIEDMAN, THOMAS B. 1; YARKIN, RHODA J. 1; MERRIL, CARL R. 1; Affiliations: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 2/22/1974, Vol. 183 Issue 4126, p764; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Zunino, F.;
AU  - Gambetta, R.;
AU  - DiMarco, A.;
AU  - Zaccara, A.;
AU  - Luoni, G.;
T1  - Comparison of the effects of daunomycin (daunorubicin) and adriamycin on various DNA polymerases
CT  - Comparison of the effects of daunomycin (daunorubicin) and adriamycin on various DNA polymerases
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1974/03/01/
VL  - 35
IS  - Mar
SP  - 754
EP  - 760
SN  - 00085472
AD  - Div. of Experimental Onocology B, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy
N1  - Accession Number: 12-5790; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Daunorubicin--20830-81-3 Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin, comparison, doxorubicin (10:00); AHFS Class: Antineoplastic agents doxorubicin, comparison, daunorubicin; References: 43; Journal Coden: CNREA8; Section Heading: Investigational Drugs; Pharmacology
N2  - The effects of daunomycin and adriamycin (doxorubicin) on the DNA-directed activities of DNA polymerases from murine sarcoma virus, rat liver (high-molecular-weight species), Escherichia coli, and Micrococcus luteus were determined. Under all conditions tested, these compounds had greater inhibitory effect against the viral polymerase than against cellular polymerase. The inhibition of murine sarcoma virus DNA polymerase by daunomycin was competitive with respect to DNA. For viral DNA polymerase it was concluded that the inhibition was predominately caused by the interaction of daunomycin with the primer-template DNA. Also, an appreciable reversal of the daunomycin-induced inhibition of this polymerase by an increase in Mg\SU/2+\BS/ concentration is consistent with the conclusion derived by competition experiments. In contrast, the inhibition of both rat liver and M. luteus DNA polymerases was essentially noncompetitive with DNA. Also, bacterial enzymes were less sensitive to inhibition by those drugs than the virion polymerase. The strong and preferential inhibition of viral DNA polymerase is discussed in relation to a differential sensitivity of normal as compared to tumor cells observed in some cell lines.
KW  - Daunorubicin--comparison, doxorubicin-;
KW  - Doxorubicin--comparison, daunorubicin-;
KW  - Antineoplastic agents--daunorubicin, comparison, doxorubicin--effects, on various DNA polymerases;
KW  - Antineoplastic agents--doxorubicin, comparison, daunorubicin--effects, on various DNA polymerases;
KW  - Mechanism of action--daunorubicin, comparison, doxorubicin--effects, on various DNA polymerases;
KW  - Mechanism of action--doxorubicin, comparison, daunorubicin--effects, on various DNA polymerases;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Yang, Raymond K.
AU  - Douthitt, Thomas C.
T1  - Newborn Responses to Threshold Tactile Stimulation.
JO  - Child Development
JF  - Child Development
Y1  - 1974/03//
VL  - 45
IS  - 1
M3  - Article
SP  - 237
EP  - 242
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12275034; Yang, Raymond K. 1 Douthitt, Thomas C. 1; Affiliation:  1: Child Research Branch, National Institute of Mental Health.; Source Info: Mar1974, Vol. 45 Issue 1, p237; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1467-8624.ep12275034
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mantel, Nathan
AU  - Byar, David P.
T1  - Evaluation of Response-Time Data Involving Transient States: An Illustration Using Heart-Transplant Data.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1974/03//
VL  - 69
IS  - 345
M3  - Article
SP  - 81
SN  - 01621459
AB  - The problem considered is how to compare time-to-response data for different groups when the group membership of an individual can be arbitrarily varied during a study. Modified life tables can be constructed which reflect such changes in an individual's status, and associated measures of relative risk and statistical significance calculated. This is illustrated with survival data for heart-transplant patients, for which a patient can transfer from the nontransplanted to the transplanted group. Alternative procedures are given in which distinctive groups are defined for each transplant day. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICAL hypothesis testing
KW  - MATHEMATICAL statistics
KW  - STATISTICS
KW  - HEART transplantation -- Patients
KW  - SURVIVAL analysis (Biometry)
KW  - BIOMETRY
KW  - FAILURE time data analysis
KW  - HEART transplantation
N1  - Accession Number: 4607533; Mantel, Nathan 1; Byar, David P. 2; Affiliations: 1: Mathematical statistician, Biometry Branch, National Cancer Institute, Bethesds, Md. 20014.; 2: Head of the Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, Bethesds, Md. 20014.; Issue Info: Mar1974, Vol. 69 Issue 345, p81; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICS; Subject Term: HEART transplantation -- Patients; Subject Term: SURVIVAL analysis (Biometry); Subject Term: BIOMETRY; Subject Term: FAILURE time data analysis; Subject Term: HEART transplantation; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Bartko, John J.
T1  - Introduction to Linear Models (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1974/03//
VL  - 69
IS  - 345
M3  - Book Review
SP  - 277
SN  - 01621459
AB  - Reviews the book "Introduction to Linear Models," by Joe H. Ward Jr. and Earl Jennings.
KW  - LINEAR models (Statistics)
KW  - NONFICTION
KW  - WARD, Joe
KW  - WARD, Joe H.
KW  - JENNINGS, Earl
KW  - INTRODUCTION to Linear Models (Book)
N1  - Accession Number: 4609214; Bartko, John J. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Mar1974, Vol. 69 Issue 345, p277; Thesaurus Term: LINEAR models (Statistics); Subject Term: NONFICTION; Reviews & Products: INTRODUCTION to Linear Models (Book); People: WARD, Joe; People: WARD, Joe H.; People: JENNINGS, Earl; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Goldberger, Robert F.
T1  - Autogenous Regulation of Gene Expression.
JO  - Science
JF  - Science
Y1  - 1974/03//3/ 1/1974
VL  - 183
IS  - 4127
M3  - Article
SP  - 810
EP  - 816
SN  - 00368075
N1  - Accession Number: 85345126; Goldberger, Robert F. 1; Affiliations: 1: Chief of Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/ 1/1974, Vol. 183 Issue 4127, p810; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LEWIS, BRIAN J.
AU  - ABRELL, JOHN W.
AU  - SMITH, R. GRAHAM
AU  - GALLO, ROBERT C.
T1  - Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase.
JO  - Science
JF  - Science
Y1  - 1974/03//3/ 1/1974
VL  - 183
IS  - 4127
M3  - Article
SP  - 867
EP  - 869
SN  - 00368075
AB  - DNA polymrlerase III is ani enzymle activity in eukaryotic cells which under certain conditions shows stronzg preference for polyadetnylic acid as tenzplate when primed by oligodeoxythymnidylate. Its first complete separationt from other DNA polymerases in huemanz lymnphoblasts is reported. This enzyme is biochemically and immunologically distinct from DNA polymerase I and from viral reverse transcriptase from a primate type C virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345152; LEWIS, BRIAN J. 1; ABRELL, JOHN W. 1; SMITH, R. GRAHAM 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/ 1/1974, Vol. 183 Issue 4127, p867; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
T1  - DISCRIMINATION, PERSONALITY AND ACHIEVEMENT: A SURVEY OF NORTHERN BLACKS (Book).
JO  - Social Forces
JF  - Social Forces
Y1  - 1974/03//
VL  - 52
IS  - 3
M3  - Book Review
SP  - 424
EP  - 425
PB  - Oxford University Press / USA
SN  - 00377732
N1  - Accession Number: 13522500; Rosenberg, Morris 1; Affiliation:  1: National Institute of Mental Health; Source Info: Mar74, Vol. 52 Issue 3, p424; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2009-11237-001
AN  - 2009-11237-001
AU  - Bouthilet, Lorraine
T1  - 'A place in the country': Dr. Bouthilet replies.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1974///Spr 1974
VL  - 1
IS  - 8
SP  - 5
EP  - 5
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11237-001. Partial author list: First Author & Affiliation: Bouthilet, Lorraine; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Facility Environment; Psychiatric Hospitals; Therapeutic Environment. Minor Descriptor: Rural Environments. Classification: Inpatient & Hospital Services (3379). Page Count: 1. Issue Publication Date: Spr 1974. 
AB  - The current author would like to that Dr. Elinson (see record [rid]2009-11239-001[/rid]) and Dr. Rubin (see record [rid]2009-11238-001[/rid]) for their comments on her original article (see record [rid]2009-11214-001[/rid]). While agreeing with Dr. Rubin that research should receive the highest priority in mental health funding, her main point was that, until we do know more about etiology and effective treatment for schizophrenia, we can perhaps provide a more humane atmosphere in service organizations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental hospitals
KW  - state institutions
KW  - asylums
KW  - facility conversion
KW  - reuse
KW  - repurposing
KW  - 1974
KW  - Facility Environment
KW  - Psychiatric Hospitals
KW  - Therapeutic Environment
KW  - Rural Environments
KW  - 1974
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-11233-001
AN  - 2009-11233-001
AU  - Rosenthal, David
T1  - Introduction to Manfred Bleuler’s 'The offspring of schizophrenics'.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1974///Spr 1974
VL  - 1
IS  - 8
SP  - 91
EP  - 92
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11233-001. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, Division of Clinical, Behavioral, and Biological Research, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Offspring; Schizophrenia. Minor Descriptor: Experimentation. Classification: Schizophrenia & Psychotic States (3213). Page Count: 2. Issue Publication Date: Spr 1974. 
AB  - This article introduces Manfred Bleuler and his work 'The offspring of Schizophrenics' which is unique work in the field of psychiatry. From a research standpoint, he has: specified his criteria for the diagnosis of schizophrenia clearly and thoroughly; developed a most useful method for representing clinical course graphically; assessed course and outcome in schizophrenia more definitely than it has ever been done before, with many new insights; compared acute and chronic schizophrenia; evaluated the impact of schizophrenic parents on their children at different ages, the social relationships at home, and the impact of IQ and social class level in a way that has never been done before; compared proband sibs with proband offspring in a unique analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Manfred Bleuler
KW  - The offspring of schizophrenia
KW  - schizophrenia research
KW  - 1974
KW  - Offspring
KW  - Schizophrenia
KW  - Experimentation
KW  - 1974
DO  - 10.1093/schbul/1.8.91
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Stadtman, Thressa C.
T1  - Selenium Biochemistry.
JO  - Science
JF  - Science
Y1  - 1974/03/08/
VL  - 183
IS  - 4128
M3  - Article
SP  - 915
EP  - 922
SN  - 00368075
N1  - Accession Number: 85345164; Stadtman, Thressa C. 1; Affiliations: 1: Biochemist, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/ 8/1974, Vol. 183 Issue 4128, p915; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARSTAD, P.
AU  - RUDIKOFF, S.
AU  - POTTER, M.
AU  - COHN, M.
AU  - KONIGSBERG, W.
AU  - HOOD, L.
T1  - Imunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine.
JO  - Science
JF  - Science
Y1  - 1974/03/08/
VL  - 183
IS  - 4128
M3  - Article
SP  - 962
EP  - 964
SN  - 00368075
AB  - The amino terminal sequences of five light and heavy immunoglobulin chains from myeloma proteins of the BALBIc mouse with binding activity to phosphorylcholine are presented. Except for a single substitution in position 4, all five heavy chains have identical amino terminal sequences through the first hypervariable region. Proteins which share unique (idiotypic) antigenic determinants are identical through the first hypervariable region of their light and heavy chains. Proteins with differing idiotypic determinants have light chains of differing amino acid sequence. These observations suggest that the heavy chain plays a more important role than the light chain in determining the phosphorylcholine binding site. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345189; BARSTAD, P. 1; RUDIKOFF, S. 2; POTTER, M. 2; COHN, M. 3; KONIGSBERG, W. 4; HOOD, L. 5; Affiliations: 1: Division of Biology, California Institute of Technology, Pasadena 91109; 2: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 3: Salk Institute for Biological Studies, San Diego, California 92112; 4: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510; 5: Division of Biology, California Instituite of Technology; Issue Info: 3/ 8/1974, Vol. 183 Issue 4128, p962; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FEARS, THOMAS R.
AU  - SCHNEIDERMAN, MARVIN A.
T1  - Pathologic Evaluation and the Blind Technique.
JO  - Science
JF  - Science
Y1  - 1974/03/22/
VL  - 183
IS  - 4130
M3  - Article
SP  - 1143
EP  - 1144
SN  - 00368075
N1  - Accession Number: 85345242; FEARS, THOMAS R. 1; SCHNEIDERMAN, MARVIN A. 1; Affiliations: 1: National Institutes of Health, Nationa Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/22/1974, Vol. 183 Issue 4130, p1143; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - COSMIDES, GEORGE J.
T1  - Pharmacology and Toxicology Applied to the Treatment of Patients.
JO  - Science
JF  - Science
Y1  - 1974/03/22/
VL  - 183
IS  - 4130
M3  - Article
SP  - 1219
EP  - 1221
SN  - 00368075
N1  - Accession Number: 85345277; COSMIDES, GEORGE J. 1; Affiliations: 1: National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 3/22/1974, Vol. 183 Issue 4130, p1219; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kleinman, L. M.;
AU  - Tangrea, J. A.;
AU  - Gallelli, J. P.;
T1  - Control of investigational drugs in a research hospital
CT  - Control of investigational drugs in a research hospital
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1974/04/01/
VL  - 31
IS  - Apr
SP  - 368
EP  - 371
SN  - 00029289
AD  - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-2571; Language: English; References: 2; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2  - The responsibilities of the clinical investigator and the pharmacy department for investigational drugs at the Clinical Center, National Institutes of Health, are described. Procedures for review of research protocol, product formulation, logistics of distribution, and control and accountability for drug use are presented. Control of investigational drugs by the pharmacy department decreases the likelihood of unauthorized use and assures more complete and accessible patient drug records.
KW  - Drugs, investigational--control--pharmacists, role, in research hospital;
KW  - Control--drugs, investigational--pharmacists, role, in research hospital;
KW  - Pharmacists, hospital--drugs, investigational--control, in research hospital;
KW  - Pharmacy, institutional, hospital--drug information--drugs, investigational, control, role of pharmacist;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ablon, S. L.;
AU  - Goodwin, F. K.;
T1  - High frequency of dysphoric reaction to tetrahydrocannabinol among depressed patients
CT  - High frequency of dysphoric reaction to tetrahydrocannabinol among depressed patients
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1974/04/01/
VL  - 131
IS  - Apr
SP  - 448
EP  - 453
SN  - 0002953X
AD  - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-1468; Language: English; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants tetrahydrocannabinol; References: 35; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology; Abstract Author: C. Robert Sturwold
N2  - A high incidence of dysphoric reactions to delta-9-tetrahydrocannabinol (I) administered under double blind conditions to a homogeneous population of 8 unipolar and 5 bipolar depressed hospitalized patients is reported. Patients received I tablets in a sesame oil vehicle in doses ranging from 5 mg. orally once a day to 20 mg. orally twice daily for 1 to 7 days. All patients were rated twice daily for depression, mania, anxiety, psychosis, anger, and dysphoria. Six of the 8 unipolar patients had dysphoric reactions to I, while only 1 of 5 bipolar had similar experiences. Based on the final evaluations, it was suggested that I be classified as a mood intensifier rather than as an euphoriant. Case studies are presented.
KW  - Tetrahydrocannabinol--antidepressants-;
KW  - Antidepressants--tetrahydrocannabinol--tablets, effects, in unipolar and bipolar patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Wittman, Milton
T1  - Social Work Manpower for the Health Services: Problems and Prospects.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1974/04//
VL  - 64
IS  - 4
M3  - Article
SP  - 370
EP  - 375
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the issues concerning the training and deployment of social work manpower in the U.S. Manpower problems involved in providing health and medical care services to the total population of the country has, for the first, been recognized by health professionals, the consumers of services and policy-makers. Another concern in the country's health system is the significant changes in the organization and structure of the health and mental health services, which will have great impact on the ultimate delivery of service.
KW  - Public health
KW  - UNITED States
KW  - Labor supply
KW  - Social workers -- United States
KW  - Human services personnel
KW  - Medical care -- United States
KW  - Consumers -- United States
KW  - Mental health services
KW  - Social services
KW  - United States
N1  - Accession Number: 7971160; Wittman, Milton 1; Affiliations: 1: Chief, Social Work Training Branch, Division of Manpower and Training Programs, National Institute of Mental Health, Alcoholism, Drug Abuse, and Mental Health Administration, U.S. Department of Health, Education, and Welfare. Rockville, Maryland 20852; Issue Info: Apr1974, Vol. 64 Issue 4, p370; Thesaurus Term: Public health; Subject Term: UNITED States; Subject Term: Labor supply; Subject Term: Social workers -- United States; Subject Term: Human services personnel; Subject Term: Medical care -- United States; Subject Term: Consumers -- United States; Subject Term: Mental health services; Subject Term: Social services; Subject: United States; NAICS/Industry Codes: 561320 Temporary Help Services; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Galanter, M.;
AU  - Stillman, R.;
AU  - Wyatt, R. J.;
AU  - Vaughan, T. B.;
AU  - Weingartner, H.;
AU  - \ET/;
T1  - Marihuana and social behavior
CT  - Marihuana and social behavior
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/04/01/
VL  - 30
IS  - Apr
SP  - 518
EP  - 521
AD  - Reprints: Albert Einstein College of Medicine, Bronx Municipal Hospital Center, Dept. of Psychiatry, Jacobi Hospital, Rm. 118, Bronx, New York 10461
AD  - Laboratory of Clinical Psychopharmacology of the National Institute of Mental Health, Washington, D.C.
N1  - Accession Number: 12-5621; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Cannabis--8063-14-7; References: 23; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - In a study of 36 unpaid volunteer subjects who were experienced marihuana users, marihuana (cannabis) was found to act as a mild psychotomimetic.
KW  - Cannabis--effects-;
KW  - Drug abuse--cannabis--effects, psychotomimetic, in users;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lee, R. C. T.
AU  - Chang, C. L.
AU  - Waldinger, R. J.
AU  - Standish, T. A.
T1  - An Improved Program-Synthesizing Algorithm and Its Correctness.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1974/04//
VL  - 17
IS  - 4
M3  - Article
SP  - 211
EP  - 217
SN  - 00010782
AB  - An improved program-synthesizing algorithm based on the algorithm proposed by Waldinger and Lee in 1969 is given In the old algorithm, the program-synthesizing problem is translated into a theorem-proving problem, and a program is obtained by analyzing a proof. For the improved algorithm, the analysis is not necessary, and a program is obtained as soon as the proof is completed. This is achieved by using a modified variable tracing mechanism invented by Green in 1969. The correctness of the Improved algorithm is also proved; i.e. the program thus obtained always satisfies the specification. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPUTER algorithms
KW  - ONLINE algorithms
KW  - COMPUTER programming
KW  - ELECTRONIC data processing
KW  - MATHEMATICAL analysis
KW  - PROGRAMMING languages (Electronic computers)
KW  - consequence finding
KW  - primitive resolutions
KW  - program-synthesizing algorithms
KW  - theorem proving
N1  - Accession Number: 5225220; Lee, R. C. T. 1 Chang, C. L. 1 Waldinger, R. J. 2 Standish, T. A.; Affiliation:  1: Heuristics Laboratory, Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20014.  2: Stanford Research Institute, Menlo Park, CA 94025.; Source Info: Apr1974, Vol. 17 Issue 4, p211; Subject Term: COMPUTER algorithms; Subject Term: ONLINE algorithms; Subject Term: COMPUTER programming; Subject Term: ELECTRONIC data processing; Subject Term: MATHEMATICAL analysis; Subject Term: PROGRAMMING languages (Electronic computers); Author-Supplied Keyword: consequence finding; Author-Supplied Keyword: primitive resolutions; Author-Supplied Keyword: program-synthesizing algorithms; Author-Supplied Keyword: theorem proving; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541519 Other Computer Related Services; NAICS/Industry Codes: 511210 Software Publishers; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); Number of Pages: 7p; Illustrations: 12 Diagrams; Document Type: Article
L3  - 10.1145/360924.360967
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Young-Cooper, Glendowlyn O.
AU  - Mage, Rose G.
T1  - Neutralization of Allotype Suppression in Rabbits.
JO  - Immunology
JF  - Immunology
Y1  - 1974/04//
VL  - 26
IS  - 4
M3  - Article
SP  - 809
EP  - 817
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Data are presented which show that allotype suppression by maternal antibody can be neutralized either by foster nursing or by intraperitoneal injections of serum with paternal allotype and that the phenomenon occurs with allotypes of both the a and b loci. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN allotypes
KW  - IMMUNOGENETICS
KW  - GENETIC polymorphisms
KW  - SERUM
KW  - INTRAPERITONEAL injections
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 12826278; Young-Cooper, Glendowlyn O. 1 Mage, Rose G. 1; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of health. Bethesda, Maryland 20014, U.S.A.; Source Info: Apr74, Vol. 26 Issue 4, p809; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: IMMUNOGENETICS; Subject Term: GENETIC polymorphisms; Subject Term: SERUM; Subject Term: INTRAPERITONEAL injections; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Balter, M. B.;
AU  - Levine, J.;
AU  - Manheimer, D. I.;
T1  - Cross-national study of the extent of anti-anxiety/sedative drug use
CT  - Cross-national study of the extent of anti-anxiety/sedative drug use
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/04/04/
VL  - 290
IS  - Apr 4
SP  - 769
EP  - 774
SN  - 00284793
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852
N1  - Accession Number: 11-4061; Language: English; References: 6; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics
N2  - National samples of respondents in 9 Western European countries were asked identical questions about their use of anti-anxiety/sedative drugs during the past year and about their general attitude toward tranquilizers. The 9 countries in which the surveys were carried out were Belgium, Denmark, France, Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom. The proportion of persons who used anti-anxiety/sedative drugs on 1 or more occasions varied from 17% in Belgium and France to 10% in Spain. In almost every country the percentage of females who had used anti-anxiety/sedative drugs was approximately twice that of males. Persons 45 years of age and over were over-represented among drug users in all countries in relation to their presence in the national population. The rank order of the countries on attitude toward tranquilizers was poorly correlated with rank order on use rates. However, within each country there was a sharp difference in attitude between users and nonusers. Independent data place the United States in a middle position among the 9 countries surveyed on use of anti-anxiety/sedative drugs.
KW  - Sedatives and hypnotics--use--statistics, patients, Europe;
KW  - Psychotherapeutic agents--use--statistics, patients, Europe;
KW  - Tranquilizers--use--statistics, patients, Europe;
KW  - Statistics--sedatives and hypnotics--use, patients, Europe;
KW  - Statistics--psychotherapeutic agents--use, patients, Europe;
KW  - Statistics--tranquilizers--use, patients, Europe;
KW  - Europe--psychotherapeutic agents--use, patients, statistics;
KW  - Europe--tranquilizers--use, patients, statistics;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - PURCELL, ROBERT H.
T1  - Hepatitis Research.
JO  - Science
JF  - Science
Y1  - 1974/04/05/
VL  - 184
IS  - 4132
M3  - Article
SP  - 9
EP  - 9
SN  - 00368075
N1  - Accession Number: 85345319; PURCELL, ROBERT H. 1,2; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy, Bethesda, Maryland 20014; 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p9; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Bourne, H. R.
AU  - Lichtenstein, L. M.
AU  - Melmon, K. L.
AU  - Henney, C. S.
AU  - Weinstein, Y.
AU  - Shearerq, G. M.
T1  - Modulation of Inflammation and Immunity by Cyclic AMP.
JO  - Science
JF  - Science
Y1  - 1974/04/05/
VL  - 184
IS  - 4132
M3  - Article
SP  - 19
EP  - 28
SN  - 00368075
N1  - Accession Number: 85345322; Bourne, H. R. 1,2; Lichtenstein, L. M. 3; Melmon, K. L. 1,2; Henney, C. S. 3; Weinstein, Y. 1,2; Shearerq, G. M. 4; Affiliations: 1: Member, Department of Medicine, Division of Clinical Pharmacology, University of California Medical Center, San Francisco, California 94143; 2: Member, Department of pharmacology, Division of Clinical Pharmacology, University of California Medical Center, San Francisco, California 94143; 3: Member, Division of Immunology, Good Samaritan Hospital, Johns Hopkins University, Baltimore, Maryland 21239; 4: Member, Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p19; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DRISCOLL, BERNARD F.
AU  - KRAMER, ALLAN J.
AU  - KIES, MARIAN W.
T1  - Myelin Basic Protein: Location of Multiple Independent Antigenic Regions.
JO  - Science
JF  - Science
Y1  - 1974/04/05/
VL  - 184
IS  - 4132
M3  - Article
SP  - 73
EP  - 75
SN  - 00368075
AB  - Immnunization of guinea pigs with homologous myelin basic protein induces antibodies that differ in their ability to bind specific peptide fragments of the protein. Antiserums with differing specificities made it possible to demonstrate at least three mutually exclusive antigenic sites in the protein mnolecule. One of these sites is located between residues 44 and 89, another between 90 and 116, and the third between 117 and 170. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345347; DRISCOLL, BERNARD F. 1; KRAMER, ALLAN J. 1; KIES, MARIAN W. 1; Affiliations: 1: Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p73; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GAY, VERNON L.
AU  - TOMACARI, R. L.
T1  - Follicle-Stimulating Hormone Secretion in the Female Rat: Cyclic Release Is Dependent on Circulating Androgen.
JO  - Science
JF  - Science
Y1  - 1974/04/05/
VL  - 184
IS  - 4132
M3  - Article
SP  - 75
EP  - 77
SN  - 00368075
AB  - In adult cyclic female rats, intravenous injections of an antiserum to testosterone prevented the continued increase in serum follicle-stimulating hormone (FSH) which normally occurs during the early morning hours of estrus. This treatment did not prevent the initial increases in serum FSH (and luteinizing hormone) which occur during the critical period (1400 to 2000 of proestrus), nor did it interfere with subsequent ovulation. These observations indicate the existence of two separate mechanisms for preovulatory FSH release in the rat and implicate circulating testosterone as FSH during estrus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345348; GAY, VERNON L. 1,2; TOMACARI, R. L. 1; Affiliations: 1: Department of Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261; 2: Career Development awardee, National Institute of Child Health and Human Development; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p75; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - OKA, TAKAMI
T1  - Spermidine in Hormone-Dependent Differentiation of Mammary Gland in vitro.
JO  - Science
JF  - Science
Y1  - 1974/04/05/
VL  - 184
IS  - 4132
M3  - Article
SP  - 78
EP  - 80
SN  - 00368075
AB  - Stimulation of milk-protein synthesis in mouse mammary epithelium in vitro requires insulin, hydrocortisone, and prolactin. The requirement for hydrocortisone can be replaced by spertmidine. The possibility that spermidine mediates the effect of glucocorticoid is also supported by the observation that the cellular spermidine concentration increases before the accelerated synthesis of casein and α-lactalbumin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345350; OKA, TAKAMI 1,2; Affiliations: 1: National Institute of Arthritis, Metabolism, Maryland 20014; 2: Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p78; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PARKS, WADE P.
AU  - SCOLNICK, EDWARD M.
AU  - KOZIKOWSKI, EDMUND H.
T1  - Dexamethasone Stimulation of Murine Mammary Tumor Virus Expression: A Tissue Culture Source of Virus.
JO  - Science
JF  - Science
Y1  - 1974/04/12/
VL  - 184
IS  - 4133
M3  - Article
SP  - 158
EP  - 160
SN  - 00368075
AB  - In mouse cell lines derived from mammary adenocarcinomnas, the synthetic steroid dexamnethasone stimulates production of murine mamnmary tumor virus. Viral RNA and antigens are increased as much as 20-fold, and culture fluid supernatants froml steroid-treated cells contain type B particles with reverse transcriptase. These cells provide a possible tissue culture source of this virus and a model system for studying the mechanism of action of corticosteroids and the regulation of transcription of integrated viral DNA. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345387; PARKS, WADE P. 1; SCOLNICK, EDWARD M. 1; KOZIKOWSKI, EDMUND H. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Meloy Laboratories, Rockville, Maryland 20850; Issue Info: 4/12/1974, Vol. 184 Issue 4133, p158; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BROWNSTEIN, MICHAEL
AU  - AXELROD, JULIUS
T1  - Pineal Gland: 24-Hour Rhythm in Norepinephrine Turnover.
JO  - Science
JF  - Science
Y1  - 1974/04/12/
VL  - 184
IS  - 4133
M3  - Article
SP  - 163
EP  - 165
SN  - 00368075
AB  - There is a 24-hour rhythm in the turnover of norepinephrine in sympathetic nerves innervating the pineal gland. This rhythm persists in blinded animals but is suppressed in normnal rats by light. The rhythm in norepinephrine turnover generates the rhythins in pineal indoleamines and N-acetyltransferase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345390; BROWNSTEIN, MICHAEL; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 4/12/1974, Vol. 184 Issue 4133, p163; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SELKIRK, JAMES K.
AU  - CROY, ROBERT G.
AU  - GELBOIN, HARRY V.
T1  - Benzo[a]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography.
JO  - Science
JF  - Science
Y1  - 1974/04/12/
VL  - 184
IS  - 4133
M3  - Article
SP  - 169
EP  - 171
SN  - 00368075
AB  - High-pressure liquid chromatography can separate eight metabolites of benzo[a] pyrene formed by rat liver microsomes. This method offers major advantages over previous techniques used for the separation of oxygenated polycyclic aromatic hydrocarbons. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345393; SELKIRK, JAMES K. 1; CROY, ROBERT G. 1; GELBOIN, HARRY V. 1; Affiliations: 1: Molecular Carcinogenesis Section, Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/12/1974, Vol. 184 Issue 4133, p169; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Steinhart, John S.
AU  - Steinhart, Carol E.
T1  - Energy Use in the U.S. Food System.
JO  - Science
JF  - Science
Y1  - 1974/04/19/
VL  - 184
IS  - 4134
M3  - Article
SP  - 307
EP  - 316
SN  - 00368075
N1  - Accession Number: 85345422; Steinhart, John S. 1,2; Steinhart, Carol E. 3; Affiliations: 1: Professor of geology and geophysics, University of Wisconsin Madison; 2: Professor, Institute for Environmental Studies, University of Wisconsin Madison; 3: Formerly a biologist, National Institutes of Health, Science writer and editor; Issue Info: 4/19/1974, Vol. 184 Issue 4134, p307; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carman, J. S.;
AU  - Shoulson, I.;
AU  - Chase, T. N.;
T1  - Huntington's chorea treated with lithium carbonate
CT  - Huntington's chorea treated with lithium carbonate
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1974/04/27/
VL  - 1
IS  - Apr 27
SP  - 811
SN  - 00237507
AD  - Neurology Unit, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-4175; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents lithium carbonate; References: 3; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - No improvement in motor or cognitive function occurred in any of 6 patients with Huntington's chorea treated with lithium carbonate. There was an apparent worsening of motor and cognitive performance during the first 4 to 7 days of lithium treatment and during a similar period immediately following lithium withdrawal. This functional deterioration was accompanied by a transient decline in serum-calcium levels in each of the 3 patients in whom these measurements were made.
KW  - Lithium carbonate--Huntington's disease-;
KW  - Antiparkinson agents--lithium carbonate--Huntington's disease;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hardesty, C.;
AU  - Chaney, N.;
AU  - Waravdekar, V.;
AU  - Mead, J.;
T1  - Disposition of the antitumor agent, sangivamycin, in mice
CT  - Disposition of the antitumor agent, sangivamycin, in mice
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1974/05/01/
VL  - 34
IS  - May
SP  - 1005
EP  - 1009
SN  - 00085472
AD  - National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-4506; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents sangivamycin; References: 17; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Preliminary Drug Testing
N2  - In vivo studies established that sangivamycin (I) is phosphorylated and incorporated into the nucleic acids of mouse tissues. When radiolabeled I was administered to mice IP, the major component of drug in liver, heart, brain, and red blood cells was I 5\PR/-monophosphate; whereas, in spleen and kidney, the larger proportion of the drug was recovered as unmetabolized I. Small amounts of I 5\PR/-diphosphate were identified in all tissues, but I 5\PR/-triphosphate was detected only in red blood cells. There was incorporation of I into RNA and DNA of all tissues except brain, where labeling occurred only in RNA. The half-life of I in mouse blood was 50 hr after IP injection. Labeled I was retained in tissues for at least 12 days, presumably because of its intracellular phosphorylation. The main route of excretion appeared to be the kidneys; 40% of the drug-derived radioactivity was accounted for in the urine over a period of 12 days.
KW  - Sangivamycin--metabolism-;
KW  - Antineoplastic agents--sangivamycin--body distribution, and metabolism, in mice;
KW  - Blood levels--sangivamycin--half-life, and body distribution, in mice;
KW  - Tissue levels--sangivamycin--in mice;
KW  - Metabolism--sangivamycin--body distribution, in mice;
KW  - Drugs, body distribution--sangivamycin--in mice;
KW  - Half-life--sangivamycin--blood levels, and body distribution, in mice;
KW  - Excretion--sangivamycin--body distribution, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gorodetzky, C. W.;
AU  - Angel, C. R.;
AU  - Beach, D. J.;
AU  - Catlin, D. H.;
AU  - Yeh, S.;
T1  - Validity of screening methods for drugs of abuse in biological fluids. 1. Heroin in urine
CT  - Validity of screening methods for drugs of abuse in biological fluids. 1. Heroin in urine
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1974/05/01/
VL  - 15
IS  - May
SP  - 461
EP  - 472
SN  - 00099236
AD  - National Institute on Drug Abuse Addiction Research Center, Lexington, Kentucky and Walter Reed Army Institute of Research, Div. of Biochemistry and Medicine, Washington, D.C.
N1  - Accession Number: 12-5961; Language: English; Trade Name: Heroin; Generic Name: Diacetylmorphine; Chemical Name: Diacetylmorphine--561-27-3; References: 26; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Methodology; Drug Analysis
N2  - To evaluate several methods of detecting heroin (diacetylmorphine) use by urine analysis for morphine and its metabolites, single IV doses of 2.5 and 5 mg/70 kg were administered a week apart in random order to 10 nontolerant subjects and their urine was collected for the week following. Along with pre-drug control urines, each sample was coded, randomized, and analyzed under blind conditions by the following methods: (1) thin layer chromatography with iodoplatinate preceded by each of 4 extraction procedures, organic solvent and ion exchange resin impregnated paper extraction both without and with prior acid hydrolysis; (2) the free radical assay technique; (3) radioimmunoassay; and (4) the Technicon Autoanalyzer. There was a high probability of detection for the first 8 hours by all methods except 4 (which gave a low proportion of positives 8 hours after the 2.5 mg/70 kg dose); up to 16 hours with 1 and 2; and up to 32 to 48 hours with 3.
KW  - Diacetylmorphine--methodology-;
KW  - Methodology--diacetylmorphine--excretion, urinary, detection, in humans;
KW  - Excretion--diacetylmorphine--urinary, detection, methodology, in patients;
KW  - Dependence--diacetylmorphine--excretion, urinary, detection, methodology, in humans;
KW  - Chromatography, thin layer--diacetylmorphine--excretion, urinary, compared to other methodologies, in humans;
KW  - Radioimmunoassay--diacetylmorphine--excretion, urinary, compared to other methodologies, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - King Jr., L. E.
AU  - Florendo, N. T.
AU  - Solomon, S. S.
AU  - Hashimoto, K.
T1  - CYCLIC 3', 5'-NUCLEOTIDE PHOSPHODIESTERASE I. HISTOCHEMICAL LOCALIZATION IN RAT SKIN.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1974/05//
VL  - 62
IS  - 5
M3  - Article
SP  - 485
EP  - 492
SN  - 0022202X
AB  - The distribution of cyclic 3' ,5'-nucleotide phosphodiesterase activity in albino rat skin was studied by histochemical methods. The demonstrable enzymatic activity was found on or near the plasma membranes of mast cells, dermal fibroblasts, epidermal keratinocytes, and basal dendritic cells. Plasma membranes of endothelial cells and intravascular erythrocytes and leukocytes also were labeled, but the enzymatic activity of the plasma itself may have produced this labeling. Theophylline. a phosphodiesterase inhibitor, blocked the formation of demonstrable enzymatic products from exogenous cyclic AMP in rat skin. These histochemical studies show that cyclic AMP phosphodiesterase occurs in most, if not all, skin cell types. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYCLIC nucleotide phosphodiesterases
KW  - NUCLEOTIDES
KW  - NUCLEIC acids
KW  - BLOOD plasma
KW  - ERYTHROCYTES
KW  - LEUCOCYTES
N1  - Accession Number: 12681001; King Jr., L. E. 1 Florendo, N. T. Solomon, S. S. 2 Hashimoto, K. 3; Affiliation:  1: Advanced Specially Training Program in Dermatology and Research Funds, Veterans Administration  2: NIAMD, National Institutes of Health  3: Medical Investigator Award and Research Funds, Veterans Administration; Source Info: May74, Vol. 62 Issue 5, p485; Subject Term: CYCLIC nucleotide phosphodiesterases; Subject Term: NUCLEOTIDES; Subject Term: NUCLEIC acids; Subject Term: BLOOD plasma; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12681001
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06262-019
AN  - 2006-06262-019
AU  - Phillipson, Richard
T1  - Methadone Maintenance, 'A Passing Affair'.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1974/05//
VL  - 19
IS  - 5
SP  - 381
EP  - 382
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06262-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Phillipson, Richard; National Institute of Drug Abuse, Bethesda, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Rehabilitation; Methadone Maintenance; Narcotic Drugs; Social Issues; Treatment. Minor Descriptor: Methadone. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Reviewed Item: Nelkin, Dorothy. Methadone Maintenance: A Technological Fix=New York: Braziller, 1973. Pp. ix + 164. $6.95 cloth; $1.95 paper; 1973. Page Count: 2. Issue Publication Date: May, 1974. 
AB  - Reviews the book, Methadone Maintenance: A Technological Fix by Dorothy Nelkin (1973). The author claims that the study is not intended as an evaluation of the Syracuse methadone treatment program nor is it a judgment of the overall merits of methadone maintenance; it sets out to describe methadone maintenance as a social phenomenon and the implications of the increasing tendency to seek technological solutions to major social problems. In the opening chapter, 'The Addict and Society,' the author criticizes the paucity of provision for aftercare services in treatment programs of the National Institute of Mental Health. Chapter 2 addresses methadone maintenance. The author spells out the pro's and con's of the very controversial method of 'chemotherapeutic constraint' with admirable clarity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - methadone maintenance
KW  - treatment program
KW  - synthetic narcotic
KW  - social phenomena
KW  - social problems
KW  - technological solutions
KW  - chemotherapeutic constraint
KW  - 1974
KW  - Drug Rehabilitation
KW  - Methadone Maintenance
KW  - Narcotic Drugs
KW  - Social Issues
KW  - Treatment
KW  - Methadone
KW  - 1974
U2  - Nelkin, Dorothy. (1973); Methadone Maintenance: A Technological Fix; New York: Braziller, 1973. Pp. ix + 164. $6.95 cloth; $1.95 paper
DO  - 10.1037/0012662
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - MINTON, ALLEN P.
T1  - Oxygen Binding in Cyanmet Hybrid and Normal Hemoglobins: Applicability of Sequential and Two-State Concerted Models.
JO  - Science
JF  - Science
Y1  - 1974/05/03/
VL  - 184
IS  - 4136
M3  - Article
SP  - 577
EP  - 579
SN  - 00368075
AB  - The cyanmet hybrid hemoglobins ajj8+CN2 and a+ONg2,/32 are widely held to be similar or equivalent in structure and subunit interactions to the partially oxygen-liganded species %2(? * 02)2 and (a' 02)2/,82 respectively. An analysis of precise data on oxygen binding to the cyanmet hybrids and normal hemoglobin shows that if this is the case, then cooperative ligand binding in hemoglobin is more properly described by some model of the sequential type than by any twostate concerted model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345507; MINTON, ALLEN P. 1; Affiliations: 1: Laboratory of Biophysical Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/ 3/1974, Vol. 184 Issue 4136, p577; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WHITNEY JR., ROBERT A.
T1  - Ectromelia in U.S. Mouse Colonies.
JO  - Science
JF  - Science
Y1  - 1974/05/10/
VL  - 184
IS  - 4137
M3  - Article
SP  - 609
EP  - 609
SN  - 00368075
N1  - Accession Number: 85345514; WHITNEY JR., ROBERT A. 1; Affiliations: 1: Veterinary Resources Branch, Division of Research Services, Public Health Service, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/10/1974, Vol. 184 Issue 4137, p609; Number of Pages: 2/5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Masson, T. J.;
AU  - McKay, F. W.;
AU  - Miller, R. W.;
T1  - Asbestos-like fibers in Duluth water supply: relation to cancer mortality
CT  - Asbestos-like fibers in Duluth water supply: relation to cancer mortality
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1974/05/20/
VL  - 228
IS  - May 20
SP  - 1019
EP  - 1020
AD  - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-3838; Language: English; Chemical Name: Asbestos--1332-21-4; References: 6; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2  - Studies of the carcinogenic effect of asbestos-like fibers found in the water supply of Duluth in 1955, is presented. The 14 year study showed no apparent carcinogenic effect in the patterns of cancer mortality among persons of all ages, nor among children. The period of observation is short relative to the latent period for occupationally induced carcinogenesis from asbestos.
KW  - Asbestos--toxicity, environmental-;
KW  - Toxicity, environmental--asbestos--lack, carcinogenic effect, after fiber detection in water supply, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Mackie, James B.
AU  - Lloyd, Dee N.
AU  - Rafferty, Frank
T1  - The Father's Influence on the Intellectual Level of Black Ghetto Children.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1974/06//
VL  - 64
IS  - 6
M3  - Article
SP  - 615
EP  - 616
PB  - American Public Health Association
SN  - 00900036
AB  - The article investigates the father's influence on the intellectual level of Black ghetto children in the U.S. National interest has shifted on black ghetto children, especially upon their educational achievement and relationships between that achievement and family background on one hand and new educational programs on the other. Particular efforts have been made to identify a constellation of family variables that may account for a documented gap between the level of intellectual skills shown by these children and the level shown by white, middle class children of the same age.
KW  - African American children
KW  - Academic achievement
KW  - Father & child
KW  - Child development
KW  - Family relations
KW  - Ethnic neighborhoods
KW  - Inner cities
KW  - Ethnic groups
KW  - United States
N1  - Accession Number: 7971227; Mackie, James B. 1,2; Lloyd, Dee N. 3; Rafferty, Frank 4,5,6; Affiliations: 1: Associate Professor, Clinical Psychology Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School, Baltimore, Maryland 21201; 2: Director, Clinical Psychology Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School, Baltimore, Maryland 21201; 3: Research Psychologist, Mental Health Study Center, National Institute of Mental Health, Department of Health, Education, Welfare, Adelphi, Maryland 20783; 4: Professor, Child Psychiatry Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School; 5: Director, Child Psychiatry Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School; 6: Director, Institute for Juvenile Research, Chicago, Illinois 60612; Issue Info: Jun1974, Vol. 64 Issue 6, p615; Subject Term: African American children; Subject Term: Academic achievement; Subject Term: Father & child; Subject Term: Child development; Subject Term: Family relations; Subject Term: Ethnic neighborhoods; Subject Term: Inner cities; Subject Term: Ethnic groups; Subject: United States; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gorodetzky, C. W.;
AU  - Kullberg, M. P.;
T1  - Validity of screening methods for drugs of abuse in biological fluids. 2. Heroin in plasma and saliva
CT  - Validity of screening methods for drugs of abuse in biological fluids. 2. Heroin in plasma and saliva
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1974/06/01/
VL  - 15
IS  - Jun
SP  - 579
EP  - 587
SN  - 00099236
AD  - National Institute on Drug Abuse Addiction Research Center and Univ. of Kentucky College of Medicine, Dept. of Psychiatry, Lexington, Kentucky
N1  - Accession Number: 12-6622; Language: English; Chemical Name: Diacetylmorphine--561-27-3 Dextromethorphan--125-71-3 Morphine--57-27-2; Therapeutic Class: (48:00); AHFS Class: Expectorants and cough preparations dextromethorphan (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 17; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2  - Assay techniques for the determination of single doses of heroin (diacetylmorphine; I) and dextromethorphan (II) and multiple doses of morphine (III) in humans were studied. Single intravenous doses of I, 2.5, 5 and 10 mg/70 kg were given to 5 subjects; one subject received II, 60 mg/70 kg orally and 4 subjects received III, 30 mg, SC 4 times daily for 3 months. Saliva and plasma samples were collected at intervals for 48 hr following each single drug dose and hourly for 6 hr between chronic doses. Plasma samples were analyzed for opiate by radioimmunoassay and saliva samples by radioimmunoassay, free radical assay technique and the homogeneous enzyme immunoassay. The low dose of I was not consistently detectable at any sampling time in either the plasma or the saliva. The medium and high doses were detectable with high probability for 2-4 hr in plasma and 1-2 hr in saliva. II was not detectable in plasma but was detected with high probability in saliva for 30 min by enzyme imunoassay and 2 hr by free radical assay. During chronic administration there were high probabilities of detection of III in plasma for at least 6 hr and in saliva for 3-4 hr after the last III dose. While these fluids do not appear to be as useful as urine in routine screening for I, they may be useful in the detection of high dose chronic abuse.
KW  - Diacetylmorphine--methodology-;
KW  - Dextromethorphan--methodology-;
KW  - Morphine--methodology-;
KW  - Methodology--diacetylmorphine--analysis, plasma and saliva, in humans;
KW  - Methodology--dextromethorphan--analysis, plasma and saliva, in humans;
KW  - Methodology--morphine--analysis, plasma and saliva, in humans;
KW  - Expectorants and cough preparations--dextromethorphan--methodology, plasma and saliva analysis, in humans;
KW  - Analgesics and antipyretics--morphine--methodology, plasma and saliva analysis, in humans;
KW  - Blood levels--diacetylmorphine--methodology, analysis, in humans;
KW  - Blood levels--dextromethorphan--methodology, analysis, in humans;
KW  - Blood levels--morphine--methodology, analysis, in humans;
KW  - Saliva levels--diacetylmorphine--methodology, analysis, in humans;
KW  - Saliva levels--dextromethorphan--methodology, analysis, in humans;
KW  - Saliva levels--morphine--methodology, analysis, in humans;
KW  - Metabolism--diacetylmorphine--blood levels, and saliva levels, analysis, methodology, in humans;
KW  - Metabolism--dextromethorphan--blood levels, and saliva levels, analysis, methodology, in humans;
KW  - Metabolism--morphine--blood levels, and saliva levels, analysis, methodology, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - Canellos, G. P.;
AU  - Chabner, B. A.;
AU  - Schein, P. S.;
AU  - Brereton, H. D.;
AU  - \ET/;
T1  - Treatment of malignant melanoma with methyl CCNU (semustine)
CT  - Treatment of malignant melanoma with methyl CCNU (semustine)
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1974/06/01/
VL  - 15
IS  - Jun
SP  - 617
EP  - 622
SN  - 00099236
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-6482; Language: English; Trade Name: Methyl-1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; Generic Name: Semustine; Chemical Name: Semustine--13909-09-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents semustine; References: 14; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Twenty-eight patients with disseminated malignant melanoma were treated with semustine (I) administered as a single dose orally every 6 weeks. Six patients (21%) had a complete or partial regression of measurable disease. The median duration of the partial remissions was 2 months and for the one complete remission, 18 months. The median survival of those responding to therapy (10.6 months) was significantly longer than those who failed to respond (4.2 months). Regressions of skin, intracutaneous, and nodal disease were most common, but 4 patients had regression of lung metastasis and one patient had regression of bone metastasis. Toxicity was primarily delayed thrombocytopenia and to a lesser extent leukopenia occurring within 4 to 6 weeks. Hematopoietic toxicity was significant but manageable. The response rate, ease of administration, and absence of sex difference in response make I potentially useful in the chemotherapeutic management of disseminated malignant melanoma.
KW  - Semustine--melanomas-;
KW  - Antineoplastic agents--semustine--melanomas, malignant, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Martin, W. R.;
AU  - Thompson, W. O.;
AU  - Fraser, H. F.;
T1  - Comparison of graded single intramuscular doses of morphine and pentobarbital in man
CT  - Comparison of graded single intramuscular doses of morphine and pentobarbital in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1974/06/01/
VL  - 15
IS  - Jun
SP  - 623
EP  - 630
SN  - 00099236
AD  - National Institute on Drug Abuse, Addiction Research Center, Lexington, Kentucky
N1  - Accession Number: 12-6579; Language: English; Chemical Name: Pentobarbital--76-74-4 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, pentobarbital (28:24); AHFS Class: Sedatives and hypnotics pentobarbital, comparison, morphine; References: 14; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Graded single IM doses of morphine (I) sulfate (8, 16, and 32 mg) and pentobarbital (II) sodium (150, 200, and 250 mg) and a placebo were administered double blind to 12 nontolerant narcotic addicts. To assess the magnitude and time course of subjective effects and associated signs, ""single and chronic dose'' opiate questionnaires were completed by subjects and observers. Objective measurements of drug effect were concurrently made, using photographs of the pupils and the duration of postrotational nystagmus. Overall, the questionnaires showed definite and different constellations of symptoms and signs for I and II. Objective measurements were also different. I induced a dose-related decrease in pupillary diameter and an increase in the signs scratching, relaxed, coasting, talkativeness, and conjunctival injection and caused relaxation, talkativeness, and turning of the stomach. II induced a dose-related increase in the duration of postrotational nystagmus and caused sleepiness and drunkenness. Both drugs induced euphoria.
KW  - Pentobarbital--comparison, morphine-;
KW  - Morphine--comparison, pentobarbital-;
KW  - Analgesics and antipyretics--morphine, comparison, pentobarbital--effects, subjective and objective assessment, in humans;
KW  - Sedatives and hypnotics--pentobarbital, comparison, morphine--effects, subjective and objective assessment, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Howard, Cecil G.
T1  - THE RETURNING OVERSEAS EXECUTIVE: CULTURAL SHOCK IN REVERSE.
JO  - Human Resource Management
JF  - Human Resource Management
Y1  - 1974///Summer74
VL  - 13
IS  - 2
M3  - Article
SP  - 22
EP  - 26
SN  - 00904848
AB  - The article deals with two aspects of the executive's return — one with the problems usually faced by the returning executive, the family and also the company and the other, the measures that can be taken by multinational firms to make the return of the overseas executive and the family a little smoother. It is an accepted fact that when an American goes abroad he or she experiences a cultural shock. However, when they return to their own country they may well experience another cultural shock of sorts, and what is done to prevent and also to overcome this situation is extremely important. Many multinational firms in the U.S. have some kind of formal cultural sensitivity training or orientation program in which the prospective overseas executive and his or her family are thoroughly exposed to the legal, social, religious, political, business, economic, and physical environment of the country to which they are being assigned. Some go to the extent of having language courses and classes conducted by nationals from the country in question or send their executives and their families to commercial language schools for crash language training.
KW  - EXECUTIVES
KW  - INTERNATIONAL business enterprises
KW  - EMPLOYEE orientation
KW  - EMPLOYEE training
KW  - CULTURE shock
KW  - FAMILIES
KW  - UNITED States
N1  - Accession Number: 12493285; Howard, Cecil G. 1,2; Affiliations: 1: Researcher, Executive & Management Development Branch, National Institutes of Health, Bethesda, Maryland; 2: School of Business, Georgia Southern College; Issue Info: Summer74, Vol. 13 Issue 2, p22; Thesaurus Term: EXECUTIVES; Thesaurus Term: INTERNATIONAL business enterprises; Thesaurus Term: EMPLOYEE orientation; Thesaurus Term: EMPLOYEE training; Subject Term: CULTURE shock; Subject Term: FAMILIES; Subject: UNITED States; NAICS/Industry Codes: 611430 Professional and Management Development Training; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Milner, John E.
T1  - IN VITRO LYMPHOCYTE RESPONSES IN CONTACT HYPERSENSITIVITY IV.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1974/06//
VL  - 62
IS  - 6
M3  - Article
SP  - 591
EP  - 594
SN  - 0022202X
AB  - Sixteen patients were sensitized to dinitrofluorobenzene (DNFB) by topical application. Of these, 6 were determined to be 4-sensitized, in that the cutaneous application of 2,000 μg of DNFB resulted in vesiculation, erythema, and edema beyond the border of the test site. Six unsensitized patients were used as controls. The 22 subjects had their lymphocytes cultured in the presence of conjugates of DNFB and human skin (DNP- SP). Responses were quantitated by measuring the incorporation of tritiated thymidine into nucleic acids of the cells in culture. Using a ratio of 3.0 (numbers indicate the ratio of thymidine incorporation in cultures containing DNP SP to those containing univ skin protein [SPJ). 5 of 64- patients were classified as sensitive, and none of the 6 control patients responded to this extent. Of the remainder of the sensitized patients, only 2 of 10 were positive. This indicates that our method, at present, is quite effective in detecting contact sensitivity in strongly positive patients, but insensitive in weakly sensitized patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - ALLERGY
KW  - THYMIDINE
KW  - NUCLEIC acids
KW  - CELL culture
KW  - SKIN diseases
N1  - Accession Number: 12679447; Milner, John E. 1; Affiliation:  1: National Cancer Institute Research Career Development Awardee. No. 1 K4 CA 33563-01 IMB; Source Info: Jun74, Vol. 62 Issue 6, p591; Subject Term: LYMPHOCYTES; Subject Term: ALLERGY; Subject Term: THYMIDINE; Subject Term: NUCLEIC acids; Subject Term: CELL culture; Subject Term: SKIN diseases; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12679447
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DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Eckman, W. W.;
AU  - Patalk, C. S.;
AU  - Fenstermacher, J. D.;
T1  - Critical evaluation of the principles governing the advantage of intra-arterial infusions
CT  - Critical evaluation of the principles governing the advantage of intra-arterial infusions
JO  - Journal of Pharmacokinetics and Biopharmaceutics (USA)
JF  - Journal of Pharmacokinetics and Biopharmaceutics (USA)
Y1  - 1974/06/01/
VL  - 2
IS  - Jun
SP  - 257
EP  - 285
SN  - 0090466X
AD  - Membrane Transport Section, Experimental Therapeutics Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-4771; Language: English; References: 13; Journal Coden: JPBPBJ; Section Heading: Drug Metabolism and Body Distribution; Pharmacology; Abstract Author: Edwin E. Wiegand
N2  - Mathematical analysis is used to determine the relationship between the time course of drug concentration in the artery to that in the tissue after regional (intra-arterial) or systemic (IV) drug administration. The advantage of an arterial infusion is discussed from the viewpoint that it is dependent on a single probability factor and also that it is independent of the rate of infusion. Two methods are described to experimentally determine any advantage to arterial infusions. The factors that influence the advantage of decreased systemic drug delivery after arterial infusion are evaluated. The relationship between drug delivery and pharmacological activity is studied. Appendices derive the equations used.
KW  - Drug administration--routes--intra-arterial, comparison, IV, time course of drug concentration;
KW  - Drugs, body distribution--intra-arterial, comparison, intravenous--time course of drug concentration;
KW  - Injections--intra-arterial, comparison, intravenous--time course of drug concentration;
KW  - Metabolism--blood levels--intra-arterial, comparison, IV, time course of drug concentration;
KW  - Blood levels--intra-arterial, comparison, intravenous--time course of drug concentration;
KW  - Pharmacokinetics--blood levels--intra-arterial, comparison, IV, time course of drug concentration;
KW  - Drugs, availability--intra-arterial, comparison, intravenous--time course of drug concentration;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Mantel, Nathan
T1  - Comment and a Suggestion: by, Nathan Mantel.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1974/06//
VL  - 69
IS  - 346
M3  - Article
SP  - 378
SN  - 01621459
AB  - The article focuses on comments and suggestions given by the author on topics related to 2 X 2 contingency tables. In commenting on an earlier version of this article, the author suggested that the example given by statistician William J. Conover could be employed to advantage to demonstrate the propriety of using the continuity correction. The reverse demonstration by Conover related not to proper use but rather to misuse of the continuity correction. According to the author, using the continuity correction, he should try to parallel the computations of estimating tail or class-interval probabilities for a normal distribution with known mean and variance. Use of continuity-corrected chi-square for a 2 X 2 table as displayed by Conover is equivalent to considering the cell frequency α to be normally distributed. The excellent agreement between exact individual term probabilities and those based on the use of continuity-corrected chi square, except perhaps at the very extremes is apparent. Thus for one-sided significance testing the use of continuity-corrected chi square should give much the same results as Fisher's exact test. The same should be true for two-sided testing.
KW  - CORRELATION (Statistics)
KW  - PROBABILITY theory
KW  - STATISTICS
KW  - GAUSSIAN distribution
KW  - DISTRIBUTION (Probability theory)
KW  - ESTIMATION theory
KW  - VARIANCES
KW  - CONTINGENCY tables
KW  - CONTINUITY
KW  - CHI-squared test
N1  - Accession Number: 4608366; Mantel, Nathan 1; Affiliations: 1: Formerly senior mathematical statistician with the National Cancer Institute, Biostatistios Center, George Washington University, 7979 old Georgetown Rd., Bethesda, Md. 20014.; Issue Info: Jun74, Vol. 69 Issue 346, p378; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICS; Thesaurus Term: GAUSSIAN distribution; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ESTIMATION theory; Thesaurus Term: VARIANCES; Subject Term: CONTINGENCY tables; Subject Term: CONTINUITY; Subject Term: CHI-squared test; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Chand, Nanak
T1  - Sequential Tests of Composite Hypothesis.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1974/06//
VL  - 69
IS  - 346
M3  - Article
SP  - 394
SN  - 01621459
AB  - A method is given for obtaining sequential tests of composite hypotheses for a certain class of distributions. Approximate properties of the tests are derived and the method illustrated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - STATISTICAL hypothesis testing
KW  - PROBABILITY theory
KW  - TESTING
KW  - APPROXIMATION theory
KW  - HYPOTHESIS
KW  - SEQUENTIAL analysis
KW  - CHARACTERISTIC functions
N1  - Accession Number: 4608434; Chand, Nanak 1; Affiliations: 1: NIH visiting fellow, Environmental Biometry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709.; Issue Info: Jun74, Vol. 69 Issue 346, p394; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: PROBABILITY theory; Thesaurus Term: TESTING; Thesaurus Term: APPROXIMATION theory; Subject Term: HYPOTHESIS; Subject Term: SEQUENTIAL analysis; Subject Term: CHARACTERISTIC functions; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bast, R. C., Jr.;
AU  - Zbar, B.;
AU  - Borsos, T.;
AU  - Rapp, H. J.;
T1  - BCG and cancer. Parts I and II
CT  - BCG and cancer. Parts I and II
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/06/01/
VL  - 290
IS  - Jun 20; Jun 27
SP  - 1413
EP  - 1469
SN  - 00284793
AD  - Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 11-4132; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents BCG vaccines; References: 261; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - The use of BCG in the prevention of tumor growth and treatment of established tumors in animals and humans is reviewed. The combination of BCG immunotherapy with other modes of treatment and the effect of BCG on carcinogenesis are also discussed. Topics reviewed include prevention of acute leukemia by neonatal vaccination with BCG, BCG immunotherapy of human cancer, complications of BCG immunotherapy and possible mechanisms of BCG-mediated tumor suppression and regression.
KW  - BCG vaccines--cancer-;
KW  - Antineoplastic agents--BCG vaccines--cancer, therapy, review, in animals and humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - ROMERO, JORGE A.
AU  - AXELROD, JULIUS
T1  - Pineal β-Adrenergic Receptor: Diurnal Variation in Sensitivity.
JO  - Science
JF  - Science
Y1  - 1974/06/07/
VL  - 184
IS  - 4141
M3  - Article
SP  - 1091
EP  - 1092
SN  - 00368075
AB  - The responsiveness of the pineal β-adrenergic receptor that regulates serotonin-N-acetyltransferase activity is nearly ten times greater at the end of the light period (0600 to 1800 hours) than at the end of the dark period (1800 to 0600 hours). These changes in sensitivity of the postsynaptic β-adrenergic receptor are related to diurnal changes in the release of noradrenaline from sympathetic nerves innervating the pineal. Supersensitivity of the receptor appears to result from decreased release of the neurotransmitter during daytime, and subsensitivity from increased release at night. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85178976; ROMERO, JORGE A. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/ 7/1974, Vol. 184 Issue 4141, p1091; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOWERY, THOMAS G.
AU  - FREDERICK, LAFAYETTE
AU  - JOHNSON, JOE
T1  - Biomedical Research: Support for Minorities.
JO  - Science
JF  - Science
Y1  - 1974/06/21/
VL  - 184
IS  - 4143
M3  - Article
SP  - 1230
EP  - 1230
SN  - 00368075
N1  - Accession Number: 85117664; BOWERY, THOMAS G. 1; FREDERICK, LAFAYETTE 2; JOHNSON, JOE 3; Affiliations: 1: Division of Research Resources, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Biology, Atlanta University, Atlanta, Georgia 30314; 3: Department of Chemistry, Atlanta University; Issue Info: 6/21/1974, Vol. 184 Issue 4143, p1230; Number of Pages: 1p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - OKISAKA, SHIGEKUNI
AU  - KUWABARA, TOICHIRO
AU  - RAPOPORT, STANLEY I.
T1  - Selective Destruction of the Pigmented Epithelium in the Ciliary Body of the Eye.
JO  - Science
JF  - Science
Y1  - 1974/06/21/
VL  - 184
IS  - 4143
M3  - Article
SP  - 1298
EP  - 1299
SN  - 00368075
AB  - Perfusion of the internal carotid artery with hypertonic solution selectively destroys most of the pigmented epithelium of the ciliary body of the monkey eye, converts fenestrated endothelium of capillaries to continuous endothelium, and transiently breaks down the blood-aqueous barrier. The nonpigmented epithelium regenerates and the intraocular pressure returns to normal even though the pigmented epithelium is permanently destroyed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117697; OKISAKA, SHIGEKUNI 1; KUWABARA, TOICHIRO 1; RAPOPORT, STANLEY I. 2; Affiliations: 1: Laboratory of Vision Reseatrch, National Eye Institute, Bethesda, Maryland 20014; 2: Laboratory of Neurophysiology, Nationial Inistitlute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/21/1974, Vol. 184 Issue 4143, p1298; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Axelrod, Julius
T1  - The Pineal Gland: A Neurochemical Transducer.
JO  - Science
JF  - Science
Y1  - 1974/06/28/
VL  - 184
IS  - 4144
M3  - Article
SP  - 1341
EP  - 1348
SN  - 00368075
N1  - Accession Number: 85117711; Axelrod, Julius 1; Affiliations: 1: Chief, pharmacology section, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/28/1974, Vol. 184 Issue 4144, p1341; Number of Pages: 8p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - GAINER, HAROLD
T1  - Peptide Regulation of Bursting Pacemaker Activity in a Molluscan Neurosecretory Cell.
JO  - Science
JF  - Science
Y1  - 1974/06/28/
VL  - 184
IS  - 4144
M3  - Article
SP  - 1371
EP  - 1373
SN  - 00368075
AB  - Vasopressin and related peptides (10-9 to 10-6 molar) induced bursting pacemaker potential activity and altered the current-voltage relations of the membrane in a specific molluscan neurosecretory cell. These effects long outlasted the period of application of the peptides. Sensitivity of the cell to these peptides was primarily localized on the axon hillock region. The observed effects do not resemble conductance changes evoked by conventional neurotransmitters, but rather suggest a membrane regulatory role for these peptides, and thus may be indicative of a new form of information transfer in the nervous system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117731; BARKER, JEFFERY L. 1; GAINER, HAROLD 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 6/28/1974, Vol. 184 Issue 4144, p1371; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Miller, L. H.;
AU  - Glew, R. H.;
AU  - Wyler, D. J.;
AU  - Howard, W. A.;
AU  - Collins, W. E.;
AU  - \ET/;
T1  - Evaluation of clindamycin in combination with quinine against multidrug-resistant strains of Plasmodium falciparum
CT  - Evaluation of clindamycin in combination with quinine against multidrug-resistant strains of Plasmodium falciparum
JO  - Am. J. Trop. Med. Hyg.
JF  - Am. J. Trop. Med. Hyg.
Y1  - 1974/07/01/
VL  - 23
IS  - Jul
SP  - 565
EP  - 569
AD  - Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-3969; Language: English; Chemical Name: Clindamycin--18323-44-9 Quinine--130-95-0; Therapeutic Class: (8:20); AHFS Class: Plasmodicides quinine and clindamycin; References: 15; Journal Coden: AJTHAB; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The efficacy of clindamycin in combination with quinine was determined against 3 multidrug-resistant strains of Plasmodium falciparum. No recrudescences occurred after treatment with quinine 650 mg orally every 8 hours for 3 days and clindamycin 450 mg orally every 6 hours for 3 days, when administered either simultaneously or sequentially. Quinine alone for 3 days was not curative against infections with these strains. During a 3-day course of therapy, blood levels of quinine or clindamycin were not influenced by administration of the other drug.
KW  - Clindamycin--and quinine-;
KW  - Quinine--and clindamycin-;
KW  - Combined therapy--clindamycin and quinine--Plasmodium falciparum, therapy, in patients;
KW  - Combined therapy--quinine and clindamycin--Plasmodium falciparum therapy, in patients;
KW  - Plasmodicides--quinine and clindamycin--Plasmodium falciparum, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kaplan, J.;
AU  - Dawson, S.;
AU  - Vaughan, T.;
AU  - Green, R.;
AU  - Wyatt, R. J.;
T1  - Effect of prolonged chlorpromazine administration on the sleep of chronic schizophrenics
CT  - Effect of prolonged chlorpromazine administration on the sleep of chronic schizophrenics
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/07/01/
VL  - 31
IS  - Jul
SP  - 62
EP  - 66
AD  - Laboratory of Clinical Psychopharmacology, IRP National Institute of Mental Health, Saint Elizabeth's Hospital, WAW Bldg, Washington, D.C. 20032
N1  - Accession Number: 12-5306; Language: English; Trade Name: Thorazine; Generic Name: Chlorpromazine; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; References: 44; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - EEG recordings were performed on the sleep of 13 chronic male schizophrenics after 3 weeks on chlorpromazine HCl (thorazine) or placebo. Chlorpromazine reduced sleep latency and awake time but increased stage II, delta sleep, delta%, non-rapid eye movement sleep and rapid eye movement activity, latency and density.
KW  - Chlorpromazine--effects-;
KW  - Tranquilizers--chlorpromazine--effects, sleep, in schizophrenic patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Fauci, A. S.;
AU  - Dale, D. C.;
AU  - Wolff, S. M.;
T1  - Cyclophosphamide and lymphocyte subpopulations in Wegener's granulomatosis
CT  - Cyclophosphamide and lymphocyte subpopulations in Wegener's granulomatosis
JO  - Arthritis and Rheumatism (USA)
JF  - Arthritis and Rheumatism (USA)
Y1  - 1974/07/01/
VL  - 17
IS  - Jul-Aug
SP  - 355
EP  - 361
SN  - 00043591
AD  - Building 10, Room 11 B09 National Institutes of Health Bethesda, Maryland 20014
N1  - Accession Number: 12-2055; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 28; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: Pongsri Sangkachand
N2  - The specific effects of cyclophosphamide on circulating lymphocytes were compared in 3 males and 3 females aged 36-66 years receiving 25-50 mg. cyclophosphamide daily, 3 males and 3 females aged 27-66 years whose cyclophosphamide had been discontinued 2-26 months previously, and a group of normal controls. Among patients receiving cyclophosphamide, therapy ranged from 1-57 months, and, among those whose therapy was discontinued, the duration had been 1.5-57 months. The latter were divided into 2 groups: (1) 4 patients from whom the drug had been withdrawn less than 4 months previously, and (2) 2 other patients who had not taken the drug for 12-26 months. In 10 patients with Wegener's granulomatosis, low doses produced severe lymphocytopenia of long duration even after therapy ceased; a greater percentage decreased in nonrosette forming lymphocytes than in rosette forming T-lymphocytes; normal in vitro lymphocyte responses to mitogens (phytohemagglutinin, concanavalin A, and pokeweed mitogen) with suppressed responses to 1 of 2 antigens tested (streptokinase-streptodornase). This regimen did not cause severe granulocytopenia and was successful in inducing and maintaining long-term clinical remissions.
KW  - Cyclophosphamide--toxicity-;
KW  - Antineoplastic agents--cyclophosphamide--lymphocytopenia, in Wegener's granulomatosis, in patients;
KW  - Lymphocytes--cyclophosphamide--depletion, in Wegener's granulomatosis, in patients;
KW  - Toxicity--cyclophosphamide--studies, lymphocytopenia, in Wegener's granulomatosis, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Haworth, Mary R.
T1  - RELATIONSHIPS BETWEEN THE PRIMARY VISUAL MOTOR TEST, S-B VOCABULARY SUBTEST AND MENTAL AGE.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1974/07//
VL  - 30
IS  - 3
M3  - Article
SP  - 326
EP  - 330
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article analyzes the relationships among Primary Visual Motor Test (PVM) scores, Vocabulary subtest scores and mental ages on the Stanford-Binet, Form L-M, for children 5 through 8 years of age, using data from the PVM normative sample. Correlation of PVM with Vocabulary was significant, but of a lower magnitude. When mental age was partialled out correlation between tests was negligible, an indication that the PVM and Vocabulary are tapping different aspects of general intellectual functioning, presumably performance and verbal dimensions.
KW  - STANFORD-Binet Test
KW  - MENTAL age
KW  - INTELLIGENCE levels
KW  - AGE & intelligence
KW  - PSYCHOLOGICAL tests for children
KW  - CLINICAL psychology
N1  - Accession Number: 15844702; Haworth, Mary R. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jul1974, Vol. 30 Issue 3, p326; Subject Term: STANFORD-Binet Test; Subject Term: MENTAL age; Subject Term: INTELLIGENCE levels; Subject Term: AGE & intelligence; Subject Term: PSYCHOLOGICAL tests for children; Subject Term: CLINICAL psychology; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Weiss, H. D.;
AU  - Walker, M. D.;
AU  - Wiernik, P. H.;
T1  - Neurotoxicity of commonly used antineoplastic agents. Parts I and II
CT  - Neurotoxicity of commonly used antineoplastic agents. Parts I and II
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/07/01/
VL  - 291
IS  - Jul 11; Jul 18
SP  - 75
EP  - 33
SN  - 00284793
AD  - Reprints: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114
AD  - Sections of Neurological Surgery and Medicine, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland
N1  - Accession Number: 11-4094; Language: English; References: 157; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - The neurotoxicities of asparaginase, fluorouracil, methotrexate, nitrogen mustard (mechlorethamine), procarbazine, vincristine and vinblastine in humans are reviewed.
KW  - Toxicity--antineoplastic agents--neuro-, review, in humans;
KW  - Antineoplastic agents--toxicity--neuro-, review, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - FARACI, ROBERT P.
AU  - SCHOUR, LIONEL
T1  - Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Guérin in BALB/c Mice.
JO  - Science
JF  - Science
Y1  - 1974/07/05/
VL  - 185
IS  - 4145
M3  - Article
SP  - 68
EP  - 69
SN  - 00368075
AB  - Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117770; FARACI, ROBERT P. 1; SCHOUR, LIONEL 1; Affiliations: 1: Surgery Branch, National Cancer Institute, National Instituttes of Health, Bethesda, Maryland 20014; Issue Info: 7/ 5/1974, Vol. 185 Issue 4145, p68; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FUKUDA, JUN
T1  - Chloride Spike: A Third Type of Action Potential in Tissue-Cultured Skeletal Muscle Cells from the Chick.
JO  - Science
JF  - Science
Y1  - 1974/07/05/
VL  - 185
IS  - 4145
M3  - Article
SP  - 76
EP  - 78
SN  - 00368075
AB  - In addition to sodium and calcium spikes, tissue-cultured skeletal muscle cells from the chick can initiate spikes lasting tens of seconds. The peak membrane potential of the spike correlates with the chloride ion concentration, but not with the calcium or sodium ion concentration. The chloride spike is blocked by manganese ion but not by cobalt ion. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117774; FUKUDA, JUN 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/ 5/1974, Vol. 185 Issue 4145, p76; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Klippel, J. H.;
AU  - Decker, J. L.;
T1  - Relative macrocytosis in cyclophosphamide and azathioprine therapy
CT  - Relative macrocytosis in cyclophosphamide and azathioprine therapy
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1974/07/08/
VL  - 229
IS  - Jul 8
SP  - 180
EP  - 181
AD  - Building 10, Room 9N218, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-4078; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Azathioprine--446-86-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents azathioprine; References: 6; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2  - A relative increase in erythrocyte volume was observed in patients with connective tissue disease who were treated with cyclophosphamide and azathioprine.
KW  - Cyclophosphamide--adverse reactions-;
KW  - Azathioprine--adverse reactions-;
KW  - Drugs, adverse reactions--cyclophosphamide--macrocytosis, in patients with connective tissue disease;
KW  - Antineoplastic agents--cyclophosphamide--macrocytosis, in patients with connective tissue disease;
KW  - Drugs, adverse reactions--azathioprine--macrocytosis, in patients with connective tissue disease;
KW  - Antineoplastic agents--azathioprine--macrocytosis, in patients with connective tissue disease;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Brereton, H. D.;
AU  - Halushka, P. V.;
AU  - Alexander, R. W.;
AU  - Mason, D. M.;
AU  - Keiser, H. R.;
AU  - \ET/;
T1  - Indomethacin responsive hypercalcemia in a patient with renal cell adenocarcinoma
CT  - Indomethacin responsive hypercalcemia in a patient with renal cell adenocarcinoma
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/07/11/
VL  - 291
IS  - Jul 11
SP  - 83
EP  - 85
SN  - 00284793
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 11-4129; Language: English; Chemical Name: Indomethacin--53-86-1; References: 10; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - A case report is presented of a 54-year-old male in whom hypercalcemia secondary to neoplastic disease was responsive to indomethacin therapy (25 mg. orally twice a day).
KW  - Indomethacin--hypercalcemia-;
KW  - Hypercalcemia--indomethacin--therapy, secondary to neoplastic disease, in patient;
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DB  - ipa
ER  - 

TY  - JOUR
AU  - BROWNSTEIN, MICHAEL J.
AU  - PALKOVITS, MIKLOS
AU  - SAAVEDRA, JUAN M.
AU  - BASSIRI, RABIM M.
AU  - UTIGER, ROBERT D.
T1  - Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain.
JO  - Science
JF  - Science
Y1  - 1974/07/19/
VL  - 185
IS  - 4147
M3  - Article
SP  - 267
EP  - 269
SN  - 00368075
AB  - The regional distribution of thyrotropin-releasing hormzone (TRH) in rat brain was studied. The greatest concentration of TRH was found in the mnedian eminence. High concentrations were also found in several hypothalamic nuclei. Outside the hypothalamus, relatively large amounts of TRH were found in the septal and preoptic areas. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117839; BROWNSTEIN, MICHAEL J. 1; PALKOVITS, MIKLOS 1; SAAVEDRA, JUAN M. 1; BASSIRI, RABIM M. 2; UTIGER, ROBERT D. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104; Issue Info: 7/19/1974, Vol. 185 Issue 4147, p267; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GLOSSMANNE, H.
AU  - BAUKAL, A.
AU  - CATT, K. J.
T1  - Cation Dependence of High-Affinity Angiotensin II Binding to Adrenal Cortex Receptors.
JO  - Science
JF  - Science
Y1  - 1974/07/19/
VL  - 185
IS  - 4147
M3  - Article
SP  - 281
EP  - 283
SN  - 00368075
AB  - The specific binding of monoiodinated angiotensin 11 by particulate receptors from the bovine adrenal cortex is enhanced by addition of sodium and potassium ions, but not other cations. In the presence of 140 millimolar sodium, increased uptake of angiotensin II by adrenal receptors is associated with the appearance of high-affinity binding sites with an association constant of 2 X 109 liters per mole. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85117846; GLOSSMANNE, H. 1; BAUKAL, A. 1; CATT, K. J. 1; Affiliations: 1: Section on Hormonal Regulation, Reproduction Research Branch, National Inistituite of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/19/1974, Vol. 185 Issue 4147, p281; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - HAM JR., WILLIAM T.
AU  - MUELLER, HAROLD A.
AU  - GOLDMAN, ARNOLD I.
AU  - NEWNAM, BRIAN E.
AU  - HOLLAND, L. M.
AU  - KUWABARA, T.
T1  - Ocular Hazard from Picosecond Pulses of Nd: YAG Laser Radiation.
JO  - Science
JF  - Science
Y1  - 1974/07/26/
VL  - 185
IS  - 4148
M3  - Article
SP  - 362
EP  - 363
SN  - 00368075
AB  - Seven rhesus monkeys (14 eyes) wer-e exposed to 1064-nanometer radiation in single pulses of 25 to 35 picoseconds fromn a nmode-locked Nd: YA G laser. Threshold injury resulted fromi single pulses with a mnean energy of 13 ± 3 mnicrojoules. Electron microscopy of the retina revealed that damnage was highly localized in the photoreceptor and pigmented epithelial cells at the oluter retina. Menbrane disrluption, distorted outer segmtzents, and abnormnal mnelanin granules resembling fetal premelanosomnies were observed. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85345698; HAM JR., WILLIAM T. 1; MUELLER, HAROLD A. 1; GOLDMAN, ARNOLD I. 1; NEWNAM, BRIAN E. 2; HOLLAND, L. M. 2; KUWABARA, T. 3; Affiliations: 1: Department of Biophysics, Virginia Commonwealth University, Richmond; 2: L Division and H Division, Los Alamos Scientific Laboratory, Los Alamos, New Mexico 87544; 3: Natioinal Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/26/1974, Vol. 185 Issue 4148, p362; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - SAAVEDRA, JUAN M.
AU  - BROWNSTEIN, MICHAEL J.
AU  - CARPENTER, DAVID O.
AU  - AXELROD, JULIus
T1  - Octopamine: Presence in Single Neurons of Aplysia Suggests Neurotransmitter Function.
JO  - Science
JF  - Science
Y1  - 1974/07/26/
VL  - 185
IS  - 4148
M3  - Article
SP  - 364
EP  - 365
SN  - 00368075
AB  - Octopamine has been identified and measured in individual neurons from Aplysia californica. Neither dopamine nor norepinephrine was detected in these cells. Thus, in Aplysia there may be separate populations of catecholaminergic and monophenolaminergic cells. Octopamine may have functions of its own in the central nervous system of mollusks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345699; SAAVEDRA, JUAN M. 1; BROWNSTEIN, MICHAEL J. 1; CARPENTER, DAVID O. 2; AXELROD, JULIus 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Neutrobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014; Issue Info: 7/26/1974, Vol. 185 Issue 4148, p364; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dixon, R. L.;
T1  - Toxicology of environmental agents: blend of applied and basic research
CT  - Toxicology of environmental agents: blend of applied and basic research
JO  - American Journal of Pharmaceutical Education (USA)
JF  - American Journal of Pharmaceutical Education (USA)
Y1  - 1974/08/01/
VL  - 38
IS  - Aug
SP  - 348
EP  - 353
SN  - 00029459
AD  - Environmental Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
N1  - Accession Number: 13-3008; Language: English; References: 2; Journal Coden: AJPDAD; Section Heading: Pharmaceutical Education; Abstract Author: Drucella Andersen
N2  - The goal of toxicology training programs, through a strengthening of the scientific predictive base for environmental toxicology both in approach and in methodology to ensure the use of experimental animal studies, is discussed.
KW  - Toxicology--education--environmental;
KW  - Education--toxicology--environmental;
KW  - Toxicity, environmental--education--programs, toxicology, goals;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chu, K. C.;
T1  - Applications of artificial intelligence to chemistry: use of pattern recognition and cluster analysis to determine the pharmacological activity of some organic compounds
CT  - Applications of artificial intelligence to chemistry: use of pattern recognition and cluster analysis to determine the pharmacological activity of some organic compounds
JO  - Anal. Chem.
JF  - Anal. Chem.
Y1  - 1974/08/01/
VL  - 46
IS  - Aug
SP  - 1181
EP  - 1187
AD  - Computer Systems Laboratory, Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 11-4731; Language: English; References: 20; Journal Coden: ANCHAM; Section Heading: Methodology; Pharmacology
N2  - A wide variety of pattern recognition and cluster analysis techniques can correlate and classify a set of highly diversified organic molecules into their sedative and tranquilizer activity using augmented atom fragments to represent the chemical structures.
KW  - Automation, data processing, computers--pharmacology--use of pattern recognition and cluster analysis to determine activity;
KW  - Research--pharmacology--use of pattern recognition and cluster analysis to determine activity;
KW  - Cluster analysis--pharmacology--research, to determine activity of organic compounds;
KW  - Pattern recognition--pharmacology--research, to determine activity of organic compounds;
KW  - Structure-activity relationships--cluster analysis--and pattern recognition, to determine pharmacological activity;
KW  - Tranquilizers--pharmacology--use of pattern recognition and cluster analysis to identify activity;
KW  - Sedatives and hypnotics--pharmacology--use of pattern recognition and cluster analysis to identify activity;
KW  - Methodology--sedatives and hypnotics--cluster analysis and pattern recognition to identify activity;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Katz, M. M.;
AU  - Itil, T. M.;
T1  - Video methodology for research in psychopathology and psychopharmacology
CT  - Video methodology for research in psychopathology and psychopharmacology
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/08/01/
VL  - 31
IS  - Aug
SP  - 204
EP  - 210
AD  - Clinical Research Branch, National Institute of Mental Health, Dept. of H.E.W., 5600 Fishers La., Rockville, Maryland 20852
N1  - Accession Number: 12-5692; Language: English; Trade Name: Mellaril--Navane; Generic Name: Thioridazine; Thiothixene; Chemical Name: Thioridazine--50-52-2 Thiothixene--5591-45-7; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers thioridazine, comparison, thiothixene (28:16.08); AHFS Class: Tranquilizers thiothixene, comparison, thioridazine; References: 20; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Methodology; Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - The application and value of video methods in evaluating thioridazine (Mellaril) and thiothixene (Navane) showed advantages over a study that utilized conventionally designed methods. The results of analysis from video interview method showed that thioridazine appeared to be more effective in reducing anxiety and depression, whereas thiothixene therapy decreased apathy in geriatric patients with chronic brain syndrome. The method demonstrated increased sensitivity in detecting systemic and important differences in behavioral effects between the drugs. Video recording contributes to the descriptive and measurement phase of research. It improves reliability of ratings, establishes comparability of samples across settings, increases sensitivity and validity, balances, out the background characteristics of clinicians, and controls the time-related bias of raters in treatment studies.
KW  - Thioridazine--comparison, thiothixene-;
KW  - Thiothixene--comparison, thioridazine-;
KW  - Tranquilizers--thioridazine, comparison, thiothixene--effects, use of video interview methodology in evaluation;
KW  - Tranquilizers--thiothixene, comparison, thioridazine--effects, use of video interview methodology in evaluation;
KW  - Methodology--interviews--video, use in evaluation of thioridazine and thiothixene, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Soter, Nicholas A.
AU  - Austen, K. Frank
AU  - Gigli, Irma
T1  - THE COMPLEMENT SYSTEM IN NECROTIZING ANGIITIS OF THE SKIN. ANALYSIS OF COMPLEMENT COMPONENT ACTIVITIES IN SERUM OF PATIENTS WITH CONCOMITANT COLLAGEN-VASCULAR DISEASES.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1974/08//
VL  - 63
IS  - 2
M3  - Article
SP  - 219
EP  - 226
SN  - 0022202X
AB  - Profiles of serum complement components were studied in patients with necrotizing angiitis (vasculitis) of the skin and concomitant rheumatoid arthritis, Sjögren's syndrome, or systemic lupus erythematosus. In patients with either rheumatoid arthritis or Sjögren's syndrome, the early components--C1, C4, and C2--were depressed. When cryoglobulins containing mainly IgG and IgM were present in the patients with Sjögren's syndrome, there was further preferential reduction of C4 and C2 in serum and functionally active C1 molecules were present in the cryoprotein. A patient with Sjögren's syndrome and a cryoprotein containing large amounts of IgA exhibited depression of C3 levels with sparing of the early components, presumably reflecting activation of an alternate pathway of C3 consumption. Patients with systemic lupus erythematosus and vasculitis presented abnormalities of both early and late components of the complement system with a stricking depression of Clq levels. [ABSTRACT FROM AUTHOR]
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KW  - VASCULITIS
KW  - SKIN
KW  - SERUM
KW  - COLLAGEN
KW  - VASCULAR diseases
KW  - RHEUMATOID arthritis
KW  - SJOGREN'S syndrome
N1  - Accession Number: 12679439; Soter, Nicholas A. 1 Austen, K. Frank 1 Gigli, Irma 2; Affiliation:  1: Carl Herzug Fellow, American Dermatological Association  2: Recipient of Research Career Development Award AM-46409, National Institutes of Health; Source Info: Aug74, Vol. 63 Issue 2, p219; Subject Term: VASCULITIS; Subject Term: SKIN; Subject Term: SERUM; Subject Term: COLLAGEN; Subject Term: VASCULAR diseases; Subject Term: RHEUMATOID arthritis; Subject Term: SJOGREN'S syndrome; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12679439
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Otani, T. T.;
AU  - Briley, M. R.;
T1  - \b/-Hydroxyhomomethionine and \b/-hydroxymethoxinine: preparation and separation of diastereomers
CT  - \b/-Hydroxyhomomethionine and \b/-hydroxymethoxinine: preparation and separation of diastereomers
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1974/08/01/
VL  - 63
IS  - Aug
SP  - 1253
EP  - 1256
SN  - 00223549
AD  - Nucleic Acids Section, Laboratory of Biochemistry, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-6224; Language: English; References: 8; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2  - \b/-Hydroxyhomomethionine and \b/-hydroxymethoxinine were prepared by one-step condensation of the corresponding aldehydes with cupric glycinate in an alkaline medium; the diastereomers of each compound were separated by means of partitioned column chromatography.
KW  - \b/-Hydroxyhomomethionine--synthesis-;
KW  - \b/-Hydroxymethoxinine--synthesis-;
KW  - Chromatography, column--\b/-hydroxyhomomethionine--separation, diastereomers;
KW  - Chromatography, column--\b/-hydroxymethoxinine--separation, diastereomers;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Jerina, D. M.
AU  - Daly, J. W.
T1  - Arene Oxides: A New Aspect of Drug Metabolism.
JO  - Science
JF  - Science
Y1  - 1974/08/16/
VL  - 185
IS  - 4151
M3  - Article
SP  - 573
EP  - 582
SN  - 00368075
N1  - Accession Number: 85178987; Jerina, D. M. 1; Daly, J. W. 2; Affiliations: 1: Chief, Section on Oxidation Mechanisms National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Chief of Section on Pharmacodynamics, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p573; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Jacobs, Barbara B.
AU  - Uphoff, Delta E.
T1  - Immunologic Modification: A Basic Survival Mechanism.
JO  - Science
JF  - Science
Y1  - 1974/08/16/
VL  - 185
IS  - 4151
M3  - Article
SP  - 582
EP  - 587
SN  - 00368075
N1  - Accession Number: 85178988; Jacobs, Barbara B. 1; Uphoff, Delta E. 2; Affiliations: 1: Director of immunology of American Medical Center, Denver, Spivak, Colorado 80214 National Cancer Institute, Bethesda, Maryland 20014; 2: Senior investigator, Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p582; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GORMAN, A. L. F.
AU  - MCREYNOILDS, JOHN S.
T1  - Control of Membrane K+ Permeability in a Hyperpolarizing Photoreceptor: Similar Effects of Light and Metabolic Inhibitors.
JO  - Science
JF  - Science
Y1  - 1974/08/16/
VL  - 185
IS  - 4151
M3  - Article
SP  - 620
EP  - 621
SN  - 00368075
AB  - In the hyperpolarizing photoreceptors of the scallop Pecten irradians the metabolic inhibitors cyani 'e and 2,4-dinitrophenol cause a rapid hyperpolarization and increase in membrane permeability to potassium ions, similar to the effect of light. Cellular metabolism appears important in maintaining the low permeability to potassium ions necessary to keep the membrane depolarized in darkness, possibly by regulating the intracellular calcium ion concentration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85179010; GORMAN, A. L. F. 1; MCREYNOILDS, JOHN S. 2; Affiliations: 1: Department of Physiology, Boston University School of Medicine, Boston, Massachusetts 02118; 2: Laboratory of Nelurophysiology. National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p620; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BLOOM, F. E.
AU  - SIGGINS, G. R.
AU  - HOFFER, B. J.
T1  - Interpreting the Failures to Confirm the Depression of Cerebellar Purkinje Cells by Cyclic AMP.
JO  - Science
JF  - Science
Y1  - 1974/08/16/
VL  - 185
IS  - 4151
M3  - Article
SP  - 627
EP  - 629
SN  - 00368075
N1  - Accession Number: 85179014; BLOOM, F. E. 1; SIGGINS, G. R. 1; HOFFER, B. J. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p627; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Coller, B. S.;
AU  - Lundberg, W. B.;
AU  - Albright, L.;
AU  - Ommaya, A. K.;
AU  - Gralnick, H. R.;
T1  - Positive antiglobulin test after BCG immunotherapy
CT  - Positive antiglobulin test after BCG immunotherapy
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/08/29/
VL  - 291
IS  - Aug 29
SP  - 474
SN  - 00284793
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-0633; Language: English; Trade Name: CCNU; Generic Name: Lomustine; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - In an 8-year-old boy with left-parietal astrocytoma, a persistently positive direct (and later indirect) antiglobulin test developed after 8 months of the following antitumor therapy: biweekly S.C. injections of neuramidinase treated autologous tumor cells; monthly intradermal BCG and intratumoral purified protein derivative of tuberculin (via a reservoir); systemic lomustine (CCNU); and intratumoral 8-azaguanine.
KW  - BCG vaccines--combined therapy-;
KW  - Combined therapy--BCG vaccines--effects, positive antiglobulin test, in child;
KW  - Immunosuppressive agents--BCG vaccines--combined therapy, effects, positive antiglobulin test, in child;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - SLOTNICK, BURTON M.
AU  - KATZ, HOWARD M.
T1  - Olfactory Learning-Set Formation in Rats.
JO  - Science
JF  - Science
Y1  - 1974/08/30/
VL  - 185
IS  - 4153
M3  - Article
SP  - 796
EP  - 798
SN  - 00368075
AB  - Rats trained on 16 two-odor discrimination problems showed rapid acquisition of a learning set and one-trial learning by the end of the problem series. Learning to sample odor cues before responding and adoption of a "winstay, lose-shift" strategy probably accounts for the virtually errorless learning. Learning-set performance of rats trained with odor stimuli is comparable to that reported for primates trained on visual cues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158905; SLOTNICK, BURTON M. 1; KATZ, HOWARD M. 2; Affiliations: 1: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Tuifts University School of Medicine, Boston, Massachusetts 02111; Issue Info: 8/30/1974, Vol. 185 Issue 4153, p796; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levine, D. G.;
AU  - Preston, P. A.;
AU  - Lipscomb, S. G.;
AU  - Ross, W. F.;
T1  - Special program for nurse addicts
CT  - Special program for nurse addicts
JO  - American Journal of Nursing (USA)
JF  - American Journal of Nursing (USA)
Y1  - 1974/09/01/
VL  - 74
IS  - Sep
SP  - 1672
EP  - 1673
SN  - 0002936X
AD  - Clinical Research Center, National Institute of Mental Health, Lexington, Kentucky
N1  - Accession Number: 14-0613; Language: English; References: 5; Journal Coden: AJNUAK; Section Heading: Sociology, Economics and Ethics; Abstract Author: Jimmie L. Hall
N2  - A treatment and research unit designed for nurses who used drugs illicitly is described.
KW  - Dependence--nurses--therapy, program design;
KW  - Nurses--dependence--therapy, program design;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levine, D. G.;
AU  - Lipscomb, S. G.;
AU  - Preston, P. A.;
T1  - Historical approach to understanding drug abuse among nurses
CT  - Historical approach to understanding drug abuse among nurses
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1974/09/01/
VL  - 131
IS  - Sep
SP  - 1036
EP  - 1037
SN  - 0002953X
AD  - Reprints: San Francisco Methadone Treatment Program, 3626 Geary Blvd., San Francisco, California 94118
AD  - National Institute of Mental Health Research Center, Lexington, Kentucky
N1  - Accession Number: 12-2885; Language: English; References: 8; Journal Coden: AJPSAO; Section Heading: Sociology, Economics and Ethics; Abstract Author: C. Robert Sturwold
N2  - The findings of a study of 12 registered nurses who used drugs illicitly are presented. Historical antecedents of drug abuse were investigated through interviews of the nurse addict to explore personal and family history, health, finances, sexual activities, and history of drug abuse. A medical dependence became evident, manifested by early and extensive involvement in medical treatment, somatic orientation, chronic medical difficulties, dependence on alcohol, and, finally, dependence on other drugs. Irrational attitudes toward addicting substances viewed by the subjects are also considered contributory to their addiction.
KW  - Drug abuse--nurses--personal histories of 12 addicted nurses;
KW  - Nurses--drug abuse--personal histories of 12 addicted nurses;
KW  - Dependence--drugs--nurses, personal histories;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Benson Jr., J.W.
AU  - Buja, M. L.
AU  - Thompson, R. H.
AU  - Gordon Jr., R. S.
T1  - GLUCOSE UTILIZATION BY SWEAT GLANDS DURING FASTING IN MAN.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1974/09//
VL  - 63
IS  - 3
M3  - Article
SP  - 287
EP  - 291
SN  - 0022202X
AB  - Fifteen normal subjects were fasted for 3-7 days while undergoing daily sweating in an environmental chamber. Sweat lactate concentration decreased 19% and reached a new steady state by the third day of last. Recovery of 13C-labeled lactate in sweat after injection of 14C-labeled glucose was enhanced ruing starvation, suggesting preferential utilization of circulating glucose for sweat gland glycogen content decreased markedly during sweating in fasted subjects nearly complete recovery of normal glycogen content was observed 6 hr after conclusion of sweating. In the sweat gland, significant dependence upon carbohydrate metabolism persists during the fasted state. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUCOSE
KW  - SWEAT glands
KW  - CUTANEOUS glands
KW  - FASTING
KW  - LACTATES
KW  - CARBOHYDRATE metabolism
N1  - Accession Number: 12680165; Benson Jr., J.W. 1 Buja, M. L. 2 Thompson, R. H. 1 Gordon Jr., R. S. 1; Affiliation:  1: The Section on Physilogy and Clinical Nutrition, Digestive Diseases Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland, 20014.  2: The National heart and Lung Institute National Institutes of Health, Bethesda, Maryland 20014; Source Info: Sep74, Vol. 63 Issue 3, p287; Subject Term: GLUCOSE; Subject Term: SWEAT glands; Subject Term: CUTANEOUS glands; Subject Term: FASTING; Subject Term: LACTATES; Subject Term: CARBOHYDRATE metabolism; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12680165
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kiefer, James E.
AU  - Weiss, George H.
T1  - Truncated Version of a Play-the-Winner Rule for Choosing the Better of Two Binomial Populations.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1974/09//
VL  - 69
IS  - 347
M3  - Article
SP  - 807
SN  - 01621459
AB  - Results are developed for play-the-winner sampling for choosing the better of two binomial populations when the maximum number of tests is specified. It is shown that for a fixed number of tests the probability of correct selection with alternating assignment exceeds that for play- the-winner sampling. However, when the probability of correct selection is fixed, neither sampling method is uniformly better than the other as measured by the expected number of tests on the poorer population, or on the total expected number of tests. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROBABILITY theory
KW  - MATHEMATICS
KW  - MATHEMATICAL analysis
KW  - NUMERICAL analysis
KW  - BINOMIAL distribution
KW  - BINOMIAL theorem
N1  - Accession Number: 4612438; Kiefer, James E. 1; Weiss, George H. 2; Affiliations: 1: Mathematician, Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md. 20014.; 2: Chief, Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md. 20014.; Issue Info: Sep74, Vol. 69 Issue 347, p807; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICS; Thesaurus Term: MATHEMATICAL analysis; Subject Term: NUMERICAL analysis; Subject Term: BINOMIAL distribution; Subject Term: BINOMIAL theorem; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Little, Betsy Carter
AU  - Zahn, Theodore P.
T1  - Changes in Mood and Autonomic Functioning During the Menstrual Cycle.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1974/09//
VL  - 11
IS  - 5
M3  - Article
SP  - 579
EP  - 590
SN  - 00485772
AB  - The autonomic nervous system activity and mood ratings of 12 women were studied 6 days a week for a complete menstrual cycle. The daily procedure consisted of a resting period, a series of 5 mild tones, time estimation (TE), and reaction time (RT) trials, and a final resting period. Significant increase in heart rate (HR), respiration rate, and body temperature, and a significant decrease in resting skin conductance (SC) were found during the luteal phase. During the ovulatory phase there were significant increases in autonomic responsivity, as shown by greater amplitude of SC response in the TE and RT situations as well as in faster SC drop-rate and greater HR variability. All of these autonomic variability measures coincided with a significant peak in feelings of elation and vigor. Significant age effects were that older women had higher basal body temperatures, less marked HR variability, and tended to have lower levels of SC, particularly in the luteal phase of the cycle. The results are discussed in terms of the psychophysiological effects of estrogen and progesterone. [ABSTRACT FROM AUTHOR]
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KW  - MENSTRUATION
KW  - MOOD (Psychology)
KW  - AUTONOMIC nervous system
KW  - PSYCHOPHYSIOLOGY
N1  - Accession Number: 11088164; Little, Betsy Carter 1 Zahn, Theodore P. 1; Affiliation:  1: Laboratory of Psychology, National Institute of Mental Health; Source Info: Sep1974, Vol. 11 Issue 5, p579; Subject Term: MENSTRUATION; Subject Term: MOOD (Psychology); Subject Term: AUTONOMIC nervous system; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MAYER, ROBERT J.
AU  - SMITH, R. GRAHAM
AU  - GALLO, ROBERT C.
T1  - Reverse Transcriptase in Normal Rhesus Monkey Placenta.
JO  - Science
JF  - Science
Y1  - 1974/09/06/
VL  - 185
IS  - 4154
M3  - Article
SP  - 864
EP  - 867
SN  - 00368075
AB  - Particles with the morphology of type C virus have been identified from primate placentas by electron microscopy. A reverse transcriptase (RNAdependent DNA polymerase) was isolated and purified from microsomal pellets of two fresh placentas of rhesus monkeys in the early stages of gestation. This enzyme was biochemically similar yet immunologically distinct from the reverse transcriptases of known tumorigenic type C RNA viruses isolated from primates, but was immunologically related to a reverse transcriptase isolated from a type C virus obtained from normal baboon placenta. These particles may represent endogenous viruses and may ftinction in the transfer of genetic information during embryogenesis. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85136084; MAYER, ROBERT J.; SMITH, R. GRAHAM 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/ 6/1974, Vol. 185 Issue 4154, p864; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KAPIKIAN, ALBERT Z.
AU  - KIM, HYUN WHA
AU  - WYATT, RICHARD G.
AU  - RODRIGUEZ, WILLIAM J.
AU  - ROSS, SYDNEY
AU  - CLINE, W. LEE
AU  - PARROTT, ROBERT H.
AU  - CHANOCK, ROBERT M.
T1  - Reoviruslike Agent in Stools: Association with Infantile Diarrhea and Development of Serologic Tests.
JO  - Science
JF  - Science
Y1  - 1974/09/20/
VL  - 185
IS  - 4156
M3  - Article
SP  - 1049
EP  - 1053
SN  - 00368075
AB  - Reoviruslike particles were visualized by electron microscopy in stool filtrates prepared from stools of infants and young children with severe acute gastroenteritis. Patients who had such particles in their stools and whose paired acute and convalescent serums were tested developed an antibody response to the reoviruslike agent, which was measured by immune electron microscopy and by complement fixation. The reoviruslike agent was antigenically related to the epizootic diarrhea of infant mice virus and the Nebraska calf diarrhea virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117875; KAPIKIAN, ALBERT Z. 1; KIM, HYUN WHA 2; WYATT, RICHARD G. 3; RODRIGUEZ, WILLIAM J. 4; ROSS, SYDNEY 4; CLINE, W. LEE; PARROTT, ROBERT H. 4; CHANOCK, ROBERT M. 3; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Children's Hospital, Washington, D.C. 20009; 3: National Institute of Allergy and Infectious Diseases; 4: Children's Hospital; Issue Info: 9/20/1974, Vol. 185 Issue 4156, p1049; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VALLE, DAVID L.
AU  - PHANG, JAMES M.
AU  - GOODMAN, STEPHEN I.
T1  - Type 2 Hyperprolinemia: Absence of Δ¹-Pyrroline-5-Carboxylic Acid Dehydrogenase Activity.
JO  - Science
JF  - Science
Y1  - 1974/09/20/
VL  - 185
IS  - 4156
M3  - Article
SP  - 1053
EP  - 1054
SN  - 00368075
AB  - Δ¹-Pyrroline-5-carboxylic acid dehydrogenase activity was measured radioisotopically in normal and type 2 hyperprolinemia fibroblasts. The type 2 cells had no detectable activity over a range of reaction conditions whereas normal cells had easily measurable activity. This enzymatic defect accounts for the biochemnical abnormalities in type 2 hyperprolinemia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117876; VALLE, DAVID L. 1; PHANG, JAMES M. 1; GOODMAN, STEPHEN I. 2; Affiliations: 1: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Departmtient of Pediatrics, University of Colorado Medical Center, 4200 East Ninth Avenue, Denver 80220; Issue Info: 9/20/1974, Vol. 185 Issue 4156, p1053; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - YOSHIKAMI, S.
AU  - ROBINSON, W. E.
AU  - HAGINS, W. A.
T1  - Topology of the Outer Segment Membranes of Retinal Rods and Cones Revealed by a Fluorescent Probe.
JO  - Science
JF  - Science
Y1  - 1974/09/27/
VL  - 185
IS  - 4157
M3  - Article
SP  - 1176
EP  - 1179
SN  - 00368075
AB  - When N,N'-didansyl cystine binds to the cell membranes of vertebrate rods and cones its fluorescence efficiency increases about 20-fold. The entire outer segments of living cones become brilliantly fluorescent. Stained live rods, as well as most freshly detached outer segments, are only weakly fluorescent, but they become brightly fluorescent within a few seconds if their plasma membranes are osmotically ruptured. The difference in staining of rod and cones suggests that disk membranes of rods are not continuous with the plasma membranes are osmotically ruptured. The difference in staining of rod and cones plasma membrane on outer segments of photoreceptors in electrophysiological and biochemical experiments, and to study the infolding pattern of rod and cone disks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117920; YOSHIKAMI, S. 1; ROBINSON, W. E. 1; HAGINS, W. A. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/27/1974, Vol. 185 Issue 4157, p1176; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mitchell, J. R.;
AU  - Thorgeirsson, S. S.;
AU  - Potter, W. Z.;
AU  - Jollow, D. J.;
AU  - Keiser, H.;
T1  - Acetaminophen-induced hepatic injury: protective role of gluthathione in man and rationale for therapy
CT  - Acetaminophen-induced hepatic injury: protective role of gluthathione in man and rationale for therapy
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1974/10/01/
VL  - 16
IS  - Oct
SP  - 676
EP  - 684
SN  - 00099236
AD  - Lab. of Chemical Pharmacology and Hypertension-Endocrine Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 12-5243; Language: English; Chemical Name: Acetaminophen--103-90-2 Glutathione--70-18-8; References: 27; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Recent studies of acetaminophen induced liver damage in animals indicate that acetaminophen is converted in the liver to a chemically reactive arylating agent that normally is detoxified by conjugation with glutathione. When the dose of acetaminophen is large enough to deplete hepatic glutathione, however, there is extensive arylation of hepatic macromolecules and cell death. This paper presents evidence that administration of glutathione-like nucleophiles, such as cysteamine, protects mice from arylation of hepatic macromolecules, hepatic necrosis, and death caused by the reactive acetaminophen metabolite. Additional studies indicate that glutathione may serve a similar protective function in man as in other animals. Thus, logical treatment of patients overdosed with acetaminophen might be based on cysteamine or other nucleophiles.
KW  - Acetaminophen--toxicity-;
KW  - Glutathione--therapy-;
KW  - Toxicity--acetaminophen--hepatic, glutathione therapy, discussion;
KW  - Antidotes--glutathione--therapy, acetaminophen hepatic toxicity, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Little, B. C.;
AU  - Matta, R. J.;
AU  - Zahn, T. P.;
T1  - Physiological and psychological effects of progesterone in man
CT  - Physiological and psychological effects of progesterone in man
JO  - J. Nerv. Ment. Dis.
JF  - J. Nerv. Ment. Dis.
Y1  - 1974/10/01/
VL  - 159
IS  - Oct
SP  - 256
EP  - 262
AD  - Laboratory of Psychology, National Institute of Mental Health, Bldg. 10 Room 2N-315, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-4041; Language: English; Chemical Name: Progesterone--57-83-0; References: 18; Journal Coden: JNMDAN; Human Indicator: Yes; Section Heading: Pharmacology
N2  - A study of the effects of exogenously administered progesterone in males was conducted to test the hypothesis that psychophysiological changes occuring during the female menstrual cycle are progesterone-dependent. Progesterone (10 mg/day) was administered daily to 6 men during either the second or third week (double-blind) of a 4-4.5 week period. Parameters of evaluation included: skin conductance, heart rate, respiration, body temperature, and performance on several tasks. Expected increases in heart rate and respiration and changes in mood were not observed, although other physiologic parameters were altered by the drug. The data suggest that factors other than progesterone may influence the psychophysiological changes associated with premenstrual tension.
KW  - Progesterone--effects-;
KW  - Methodology--progesterone--effects, physiological and psychological, in male, correlation to changes in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kirkpatrick, Charles H.
AU  - Montes, Leopoldo F.
T1  - Chronic Mucocutaneous Candidiasis.
JO  - Journal of Cutaneous Pathology
JF  - Journal of Cutaneous Pathology
Y1  - 1974/10//
VL  - 1
IS  - 5
M3  - Article
SP  - 211
EP  - 229
SN  - 03036987
AB  - The lymphocyte transformation test is commonly employed as a correlate of delayed hypersensitivity in vitro. As a generalization it is a good correlate, although there are some exceptions. Venous blood is collected in heparin and lymphocytes are collected and placed in a culture with or without antigen. After an appropriate duration of incubation, the precursor of DNA, tritiated thymidine, is added to the cultures. The cells are then harvested and the radioactivity incorporated by the antigen-stimulated cultures and compare it to the counts in the unstimulated cultures. The difference in the counts reflects the increment of DNA synthesis by cells responding to the antigen.
KW  - GENES
KW  - MUCOCUTANEOUS leishmaniasis
KW  - CANDIDIASIS
KW  - HEPARIN
KW  - DNA
KW  - ANTIGENS
N1  - Accession Number: 11796159; Kirkpatrick, Charles H. 1 Montes, Leopoldo F. 2; Affiliation:  1: Head, Clinical Allergy and Hypersensitivity Section, Loboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland  20014, U.S.A.  2: Professor of Dermatology and Associate Professor of Microbiology, University of Alabama in Birmingham Medical Center, Birmingham, Alabama 35294,U.S.A.; Source Info: 1974, Vol. 1 Issue 5, p211; Subject Term: GENES; Subject Term: MUCOCUTANEOUS leishmaniasis; Subject Term: CANDIDIASIS; Subject Term: HEPARIN; Subject Term: DNA; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 19p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-43876-011
AN  - 2013-43876-011
AU  - Attkisson, C. Clifford
AU  - McIntyre, Marguerite H.
AU  - Hargreaves, A.
AU  - Harris, M. Robert
AU  - Ochberg, Frank M.
T1  - A working model for mental health program evaluation.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1974/10//
VL  - 44
IS  - 5
SP  - 741
EP  - 753
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Attkisson, C. Clifford, Langley Porter Neuropsychiatric Institute, University of California, San Francisco, CA, US, 94143
N1  - Accession Number: 2013-43876-011. PMID: 4611231 Partial author list: First Author & Affiliation: Attkisson, C. Clifford; University of California, San Francisco, CA, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Program Evaluation. Minor Descriptor: Mental Health; Mental Health Programs. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Oct, 1974. 
AB  - This paper describes a conceptual model of human service program evaluation, and integrates three key components of the evaluation process: a) Levels of Evaluative Activity, b) Functional Roles of the Evaluator, and c) Program Information Capability. This model has been useful in assessing evaluation capability of mental health programs, and in suggesting itineraries for enhancing evaluation capacity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health programs
KW  - program evaluation
KW  - working model
KW  - 1974
KW  - Mental Health Program Evaluation
KW  - Mental Health
KW  - Mental Health Programs
KW  - 1974
U1  - Sponsor: National Institute of Mental Health. Grant: HSM-43-72-105. Recipients: No recipient indicated
DO  - 10.1111/j.1939-0025.1974.tb01152.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - KOLB, HELGA
AU  - FAMIGLIETTI, E. V.
T1  - Rod and Cone Pathways in the Inner Plexiform Layer of Cat Retina.
JO  - Science
JF  - Science
Y1  - 1974/10/04/
VL  - 186
IS  - 4158
M3  - Article
SP  - 47
EP  - 49
SN  - 00368075
AB  - In cat retina, rod bipolar terminials do not synapse on ganglioni cells but on two types of alnacrine cell (types I and 11). Cone bipolars synapse directly oil ganglion cells and on type I ainacrines. The type II amnacrine appears to play a special internuncial role between bipolars and ganglion cells in the rod systemn. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85117949; KOLB, HELGA 1; FAMIGLIETTI, E. V. 1; Affiliations: 1: National Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/ 4/1974, Vol. 186 Issue 4158, p47; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Shoulson, I.;
AU  - Chase, T. N.;
T1  - Fenfluramine and dyskinesias
CT  - Fenfluramine and dyskinesias
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/10/17/
VL  - 291
IS  - Oct 17
SP  - 850
EP  - 851
SN  - 00284793
AD  - National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 12-0722; Language: English; Chemical Name: Fenfluramine--458-24-2; Therapeutic Class: (28:20); AHFS Class: Anorexics fenfluramine; References: 5; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Joan Lentine
N2  - The effect of fenfluramine on the metabolism of serotonin and dopamine was studied in 7 patients with various neurologic disorders. The central turnover of these monoamines was estimated by the probenecid-loading technique. The probenecid-induced accumulation of the principal metabolite of serotonin, 5-hydroxyindoleacetic acid, in lumbar spinal fluid decreased from a placebo treatment level of 89 29 ng./ml. to 30 16 ng./ml. during the administration by mouth of 120 mg. of fenfluramine ( \LT/ 0.01). The concentration of homovanillic acid, the primary dopamine metabolite, however, showed no consistent change (p \GT/ 0.05). These observations suggest that the action of fenfluramine at therapeutic dose levels may relate to effects on serotonin-mediated function\M/possibly a direct stimulation of postsynaptic serotonergic receptors. Also, these results may implicate the serotonergic system in the pathogenesis of certain drug-induced dyskinesias.
KW  - Fenfluramine--effects-;
KW  - Anorexics--fenfluramine--effects, on metabolism of dopamine and serotonin, in patients with neurologic disorders;
KW  - Mechanism of action--fenfluramine--effects, on metabolism of serotonin and dopamine, in patients with neurologic disorders;
KW  - Drugs, adverse reactions--fenfluramine--dyskinesias, mechanism of action, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Ledley, R. S.
AU  - Chiro, G. Di
AU  - Luessenhop, A. J.
AU  - Twigg, H. L.
T1  - Computerized Transaxial X-ray Tomography of the Human Body.
JO  - Science
JF  - Science
Y1  - 1974/10/18/
VL  - 186
IS  - 4160
M3  - Article
SP  - 207
EP  - 212
SN  - 00368075
N1  - Accession Number: 85118003; Ledley, R. S. 1; Chiro, G. Di 2,3; Luessenhop, A. J. 4; Twigg, H. L. 5; Affiliations: 1: President of the National Biomedical Research Foundation and professor of physiology biohysics, and radiology, Georgetown University, Washingtown, D.C. 20007; 2: Head of the section on neuorology, National Institutes of Health, Bethesda, Maryland 20014; 3: Clinical Professor of radiology, Georgetown University; 4: Chief of neurological surgery, Georgetown University; 5: Chairman of radiology, Geotgetown University; Issue Info: 10/18/1974, Vol. 186 Issue 4160, p207; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dinarello, C. A.;
AU  - Wolff, S. M.;
AU  - Goldfiner, S. E.;
AU  - Dale, D. C.;
AU  - Alling, D. W.;
T1  - Colchicine therapy for familial Mediterranean fever: double-blind trial
CT  - Colchicine therapy for familial Mediterranean fever: double-blind trial
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/10/31/
VL  - 291
IS  - Oct 31
SP  - 934
EP  - 937
SN  - 00284793
AD  - National Institutes of Health, Bldg. 10, Room 11 N-232, Bethesda, Maryland 20014
N1  - Accession Number: 12-2096; Language: English; Chemical Name: Colchicine--64-86-8; References: 24; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Eleven patients with long standing familial Mediterranean fever were studied in a double-blind trial using daily colchicine or placebo. Separate courses of colchicine, 0.6 mg. tablets, and placebo were administered in random order. Each course consisted of one tablet taken 3 times a day for 28 days. If no attacks occurred during the 28-day period, the next course was begun. During 60 courses of placebo, 38 attacks of familial Mediterranean fever occurred. In contrast, during 60 courses of colchicine only 7 attacks occurred ( \LT/ 0.001, by chi-square test). The 7 attacks on colchicine were evenly distributed throughout the study period. Although the initial dose was 3 tablets daily, most patients were maintained on 2 tablets of colchicine/day. The efficacy of the drug in preventing attacks of familial Mediterranean fever was dose related. There were no major side effects from daily colchicine except frequent loose stools, which were correctable by reduction of the dose. This study demonstrates that daily colchicine is highly effective in preventing attacks in this disorder.
KW  - Colchicine--fever-;
KW  - Fever--colchicine--familial Mediterranean, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Murphy, D. L.;
AU  - Beigel, A.;
T1  - Depression, elation, and lithium carbonate responses in manic patient subgroups
CT  - Depression, elation, and lithium carbonate responses in manic patient subgroups
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/11/01/
VL  - 31
IS  - Nov
SP  - 643
EP  - 648
AD  - Laboratory of Clinical Sciences, National Institute of Mental Health, NIH Clinical Center, 10-3S229, Bethesda, Maryland 20014
N1  - Accession Number: 12-5827; Language: English; Trade Name: Lithionate--Eskalith; Generic Name: Lithium carbonate; Lithium carbonate; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 22; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Oral lithium carbonate (Lithionate; Eskalith), 1.2-2.1 g/day, was administered to 26 of 30 manic depressant patients to determine the depressive elements observed on a quantitative behavioral rating scale during manic episodes. Of 15 patients who were experiencing manic episodes, 9 improved with lithium carbonate therapy. Most responders were in the subgroup of elated-grandiose patients. There were 17 episodes of depression and 6 patients received treatment during both types of episodes. Only 2 of 6 patients from the paranoid-destructive subgroup improved with lithium.
KW  - Lithium carbonate--psychoses-;
KW  - Psychotherapeutic agents--lithium carbonate--psychoses, manic-depressive, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Sack, R. L.;
AU  - Goodwin, F. K.;
T1  - Inhibition of dopamine-\b/-hydroxylase in manic patients
CT  - Inhibition of dopamine-\b/-hydroxylase in manic patients
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1974/11/01/
VL  - 31
IS  - Nov
SP  - 649
EP  - 654
AD  - Section of Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, Bldg. 10, Rm. 4S239, Bethesda, Maryland 20014
N1  - Accession Number: 13-0659; Language: English; Chemical Name: Fusaric acid--536-69-6; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents fusaric acid; References: 58; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Ronald E. Nagata, Jr.
N2  - In a double-blind controlled study with one depressed and 8 manic or hypomanic patients, fusaric acid was administered, 0.6 to 1.8 g daily, for 10 to 20 days to determine its behavioral effects and to measure its influence on laboratory tests. As a specific inhibitor of dopamine-\b/-hydroxylase (DBH) it decreases central norepinephrine without reducing dopamine. Increases in homovanillic acid, the major metabolite of dopamine, and decreases in CSF 3-methoxy 4-hydroxy-phenylglycol, the major metabolite of norepinephrine, were consistent with DBH inhibition. Behavioral effects of fusaric acid seemed to be dependent upon the pre-existing clinical state. Severe manic patients with evidence of pre-existing psychotic features became worse, while hypomanics showed no change or slight improvement.
KW  - Fusaric acid--psychoses-;
KW  - Psychotherapeutic agents--fusaric acid--psychoses, manic depressive, lack, effects, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Campbell, A.
AU  - Campbell, A A
T1  - Beyond the demographic transition.
JO  - Demography
JF  - Demography
Y1  - 1974/11//
VL  - 11
IS  - 4
M3  - journal article
SP  - 549
EP  - 561
SN  - 00703370
AB  - The article discusses about demographic transition. Two major demographic movements have dominated population growth in the world during the past thirty years. First, is the decline of death rates in the developing countries, which has brought about unusually rapid population growth, and second is the rise and subsequent decline of birth rates in some developed countries. At most, demographers thought that there would be a moderate increase after the war to compensate for the interruption of family growth during the war-and, indeed, the word compensation has been used occasionally to characterize the resurgence of childbearing in the postwar period. The developed countries appear to have gone beyond the demographic transition and to have entered an era in which fertility fluctuates mainly in response to influences other than those that reduced birth rates during the preceding three centuries.
KW  - VITAL statistics
KW  - ECONOMIC development
KW  - STATISTICS
KW  - DEMOGRAPHIC transition
KW  - SOCIAL indicators
KW  - MORTALITY
KW  - DEVELOPED countries
N1  - Accession Number: 16799052; Campbell, A. 1; Campbell, A A 2; Affiliations: 1: Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20014.; 2: Center for Population Research, National Institute of Child Health and Human Development, 20014, Bethesda, Maryland; Issue Info: Nov1974, Vol. 11 Issue 4, p549; Thesaurus Term: VITAL statistics; Thesaurus Term: ECONOMIC development; Thesaurus Term: STATISTICS; Subject Term: DEMOGRAPHIC transition; Subject Term: SOCIAL indicators; Subject Term: MORTALITY; Subject: DEVELOPED countries; Number of Pages: 13p; Document Type: journal article
L3  - 10.2307/2060470
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Butler, Robert N.
T1  - Mental health and aging. (cover story)
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1974/11//
VL  - 29
IS  - 11
M3  - Article
SP  - 59
EP  - 60
SN  - 0016867X
N1  - Accession Number: 17911344; Butler, Robert N. 1,2,3,4,5; Source Information: Nov1974, Vol. 29 Issue 11, p59; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 579
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Blank, Marie L.
T1  - Raising the age barrier to psychotherapy.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1974/11//
VL  - 29
IS  - 11
M3  - Article
SP  - 143
EP  - 148
SN  - 0016867X
N1  - Accession Number: 17911351; Blank, Marie L. 1; Source Information: Nov1974, Vol. 29 Issue 11, p143; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3571
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Barry, David W.
AU  - Schaff, Zsuzsa
AU  - Grimley, Philip M.
AU  - Hopps, Hope E.
AU  - Aptekar, Robert
T1  - MORPHOLOGIC, BIOLOGIC, AND CYTOCHEMICAL ANALYSIS OF INTRACYTOPLASMIC PARTICLES FOUND IN CULTURED FIBROBLASTS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1974/11//
VL  - 63
IS  - 5
M3  - Article
SP  - 407
EP  - 410
SN  - 0022202X
AB  - Fibroblasts grown from one involved and seven uninvolved skin sites of patients with systemic lupus erythematosus (SLE), two patients with rheumatoid arthritis (RA), and one normal patient were examined by light, fluorescent, and electron microscopy. All failed to show evidence of virus-like particles or tubuloreticular structures previously observed in the endoplasmic reticulum of tissue from patients with SLE. Densely staining intracellular punctate bodies 250-500 A in diameter were tentatively identified by differential cytochemical staining as glycogen granules. Cultures from normal. SLE and RA patients showed identical susceptibility to infection with Newcastle disease virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SYSTEMIC lupus erythematosus
KW  - FIBROBLASTS
KW  - RHEUMATOID arthritis
KW  - ENDOPLASMIC reticulum
KW  - GLYCOGEN
KW  - NEWCASTLE disease virus
N1  - Accession Number: 12676570; Barry, David W. 1 Schaff, Zsuzsa 1 Grimley, Philip M. 1 Hopps, Hope E. 2 Aptekar, Robert 2; Affiliation:  1: Laboratory of Pathology, National Cancer Institute, NIH.  2: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, NIH, Bethesda, Maryland 20014.; Source Info: Nov74, Vol. 63 Issue 5, p407; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: FIBROBLASTS; Subject Term: RHEUMATOID arthritis; Subject Term: ENDOPLASMIC reticulum; Subject Term: GLYCOGEN; Subject Term: NEWCASTLE disease virus; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12676570
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Litterst, C. L.;
AU  - Mimnaugh, E. G.;
AU  - Cowles, A. C.;
AU  - Gram, T. E.;
AU  - Guarino, A. M.;
T1  - Distribution of C14 lomustine (C14 CCNU)-derived radioactivity following intravenous administration of three potential clinical formulations to rabbits
CT  - Distribution of C14 lomustine (C14 CCNU)-derived radioactivity following intravenous administration of three potential clinical formulations to rabbits
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1974/11/01/
VL  - 63
IS  - Nov
SP  - 1718
EP  - 1721
SN  - 00223549
AD  - Laboratory of Toxicology and the Membrane Transport Section, Experimental Therapeutics, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-4489; Language: English; Chemical Name: Lomustine--13010-47-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents lomustine; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution
KW  - Lomustine--body distribution-;
KW  - Drugs, body distribution--lomustine--intravenous, in rabbits;
KW  - Metabolism--lomustine--body distribution, IV, in rabbits;
KW  - Antineoplastic agents--lomustine--body distribution, IV, in rabbits;
KW  - Formulations--lomustine--body distribution, IV, in rabbits;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dunham, L. J.;
AU  - Sheets, R. H.;
AU  - Morton, J.;
T1  - Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles
CT  - Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1974/11/01/
VL  - 53
IS  - Nov
SP  - 1259
EP  - 1269
SN  - 00278874
AD  - Laboratory of Pathology, NIH, National Cancer Institute, Dept. of Health, Education, and Public Health Service, U.S. Dept. of Health Education and Welfare, Bethesda, Maryland 20014
N1  - Accession Number: 12-4232; Language: English; Chemical Name: Arecoline--63-75-2; References: 28; Section Heading: Toxicity; Pharmacognosy
N2  - Attempts were made to develop a reliable test for the presence or absence of carcinogens in the environment. Certain plant materials suspected of affecting the development of esophageal cancer in man were applied to hamsters' upper GI tract, including cheek pouch, in several long term experiments. The materials tested, often with calcium hydroxide added, were 9 plants from Curacao used in native teas and remedies, a tobacco (used in snuff), and arecoline, present in betel quid. Lesions developing after treatment with \IT/Annona muricata, Heliotropium ternatum, Krameria ixina,\OK/ and \IT/Acacia villosa,\OK/ and with arecoline were a superficial spreading carcinoma of pouch epithelium, papillomas of esophagus (4) and advanced atypias (1 in pouch, 3 in esophagus). These lesions developed in relation to the cheeck pouch route of application only, whereas none resulted after ingestion of a concentrated tea (\IT/A. villosa\OK/), or when administered in the diet (\IT/A. muricate,\OK/ arecoline). The histologic types and distribution of the lesions in cheek pouch and esophagus suggest that they were caused by substances in the test materials tentatively presumed to be weaker or slower in action than the known chemical carcinogens.
KW  - Arecoline--carcinogens-;
KW  - Annona muricata--carcinogens--lesions, in hamster cheek pouch;
KW  - Acacia villosa--carcinogens--lesions, in hamster cheek pouch;
KW  - Heliotropium ternatum--carcinogens--lesions, in hamster cheek pouch;
KW  - Krameria ixina--carcinogens--lesions, in hamster cheek pouch;
KW  - Carcinogens--plants--Curacao, lesions, in hamster cheek pouch;
KW  - Folk medicine--plants--Curacao, teas and remedies, carcinogens, in hamster cheek pouch;
KW  - Toxicity--plants--Curacao, teas, remedies, lesions in hamster cheek pouch;
KW  - Methodology--carcinogens--plants, detection using hamsters, cheek pouch lesions;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Segerling, M.;
AU  - Ohanian, S.;
AU  - Borsos, T.;
T1  - Effect of metabolic inhibitors on killing of tumor cells by antibody and complement
CT  - Effect of metabolic inhibitors on killing of tumor cells by antibody and complement
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1974/11/01/
VL  - 53
IS  - Nov
SP  - 1411
EP  - 1413
SN  - 00278874
AD  - Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-5006; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0 Puromycin--53-79-2 Mitomycin--50-07-7 Hydroxyurea--127-07-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mitomycin (10:00); AHFS Class: Antineoplastic agents dactinomycin (10:00); AHFS Class: Antineoplastic agents hydroxyurea (10:00); AHFS Class: Antineoplastic agents puromycin; References: 11; Section Heading: Pharmacology
N2  - Resistance of guinea pig hepatoma cells (line-10) to killing by rabbit antibody and guinea pig complement was reduced by pretreatment of the cells with nontoxic doses of actinomycin D (dactinomycin), puromycin, mitomycin and hydroxyurea.
KW  - Dactinomycin--hepatoma-;
KW  - Puromycin--hepatoma-;
KW  - Mitomycin--hepatoma-;
KW  - Hydroxyurea--hepatoma-;
KW  - Antineoplastic agents--mitomycin--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
KW  - Antineoplastic agents--dactinomycin--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
KW  - Antineoplastic agents--hydroxyurea--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
KW  - Antineoplastic agents--puromycin--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Brady, R. O.;
AU  - Pentchev, P. G.;
AU  - Gal, A. E.;
AU  - Hibbert, S. R.;
AU  - Dekaban, A. S.;
T1  - Replacement therapy for inherited enzyme deficiency: use of purified glucocerebrosidase in Gaucher's disease
CT  - Replacement therapy for inherited enzyme deficiency: use of purified glucocerebrosidase in Gaucher's disease
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/11/07/
VL  - 291
IS  - Nov 7
SP  - 989
EP  - 993
SN  - 00284793
AD  - Bldg. 10, Rm. 3D-03, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-2674; Language: English; Therapeutic Class: (44:00); AHFS Class: Enzymes glucocerebrosidase; References: 22; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - The effect of IV administration of glucocerebrosidase isolated from human placenta was investigated in 2 patients with Gaucher's disease who are deficient in this enzyme. The first received one injection of 1.5 x 10\SU/6\BS/ units of glucocerebrosidase, and the second an injection of 1.65 x 10\SU/6\BS/ units on 2 successive days. Liver biopsies were obtained before and 24 hours after injection of enzyme. Glucocerebroside in the liver of the first patient decreased from 702 to 519 mcg/g and from 1634 to 1214 mcg/g in the second after infusion of glucocerebrosidase. The quantity of glucocerebroside in erythrocytes of the 2 patients before infusion was 7.4 and 6.2 mcg/ml of cells respectively and 2.9 and 2.6 mcg/ml of cells 72 hours afterward. These findings indicate that exogenous glucocerebrosidase causes definite decreased in the quantity of accumulated lipid in patients with Gaucher's disease.
KW  - Glucocerebrosidase--Gaucher's disease-;
KW  - Gaucher's disease--glucocerebrosidase--therapy, in patients;
KW  - Enzymes--glucocerebrosidase--Gaucher's disease, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - STANDLEY, KAY
AU  - SOULE III, A. BRADLEY
AU  - COPANS, STUART A.
AU  - DUCHOWNY, MICHAEL S.
T1  - Local-Regional Anesthesia during Childbirth: Effect on Newborn Behaviors.
JO  - Science
JF  - Science
Y1  - 1974/11/15/
VL  - 186
IS  - 4164
M3  - Article
SP  - 634
EP  - 635
SN  - 00368075
AB  - Administration of local-regional anesthesia during norgnal deliveries was correlated significantly with newborn behaviors as evaluated by the Brazelton neonatal assessment scale. Three days after birth, infants whose mothers received local-regional anesthesia were more irritable and motorically less mature than those infants whose mothers were not medicated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85179049; STANDLEY, KAY 1; SOULE III, A. BRADLEY 1; COPANS, STUART A. 1; DUCHOWNY, MICHAEL S. 1; Affiliations: 1: Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 11/15/1974, Vol. 186 Issue 4164, p634; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dale, D. C.;
AU  - Fauci, A. S.;
AU  - Wolfee, S. M.;
T1  - Alternate-day prednisone: leukocyte kinetics and susceptibility to infections
CT  - Alternate-day prednisone: leukocyte kinetics and susceptibility to infections
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/11/28/
VL  - 291
IS  - Nov 28
SP  - 1154
EP  - 1158
SN  - 00284793
AD  - Bldg. 10, Room 11B-13, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-1801; Language: English; Chemical Name: Prednisone--53-03-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone; References: 35; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The effects of alternate day and daily prednisone on leukocyte kinetics were studied in 20 patients with inflammatory diseases to investigate the mechanisms of corticosteroid-induced susceptibility to infections. The mean ( 1 SEM) prednisone dose for the day on drug of the patients on alternate day therapy was 37.5 6.1 mg.; the average dose for the daily therapy patients was 60.7 16.3 mg./day. With daily prednisone, both neutrophil and monocyte inflammatory responses were significantly decreased. In patients on alternate day prednisone, who were studied during the day on which prednisone was administered, neutrophilia and monocytopenia occurred, and cutaneous inflammatory responses of monocytes, but not of neutrophils, were significantly reduced. On the day of therapy of alternate day prednisone and with daily therapy the half-life of labeled blood neutrophils was significantly prolonged, and the prolongation was proportional to the dose of the drug given. In contrast, in patients maintained on alternate day prednisone therapy and studied on the day off drug, leukocyte counts, inflammatory responses and neutrophil half-life were normal.
KW  - Prednisone--dosage schedules-;
KW  - Dosage schedules--prednisone--effects, on leukocyte kinetics, in inflammatory disease patients;
KW  - Steroids, cortico---prednisone--dosage schedules, effects on leukocyte kinetics, in inflammatory disease patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Fowler, B. A.;
AU  - Weissberg, J. B.;
T1  - Arsine poisoning
CT  - Arsine poisoning
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1974/11/28/
VL  - 291
IS  - Nov 28
SP  - 1171
EP  - 1174
SN  - 00284793
AD  - Environmental Toxicology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709
N1  - Accession Number: 12-2574; Language: English; References: 75; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Joan Lentine
N2  - A review of arsine gas poisoning with emphasis on its clinical features, pathogenesis and treatment, is presented. Recent attempts to use geothermal and fossil fuel energy sources high in arsenic content may increase the frequency of arsine exposure.
KW  - Arsine--gases-;
KW  - Gases--arsine--poisoning, and therapy, discussion;
KW  - Poisoning--arsine--gases, and therapy, discussion;
KW  - Toxicity, environmental--arsine--gases, poisoning, and therapy, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - DE CLERCQ, E.
AU  - TORRENCE, P. F.
AU  - WITKOP, B.
AU  - STEWART II, W. E.
AU  - DE SOMER, P.
T1  - Interferon Induction: Tool for Establishing Interactions among Homopolyribonucleotides.
JO  - Science
JF  - Science
Y1  - 1974/11/29/
VL  - 186
IS  - 4166
M3  - Article
SP  - 835
EP  - 837
SN  - 00368075
AB  - Hitherto unrecognized interactions between homopolyribonucleotides and complexes thereof are suggested by interferon induction data obtained in a highly sensitive assay system of primary rabbit kidney cell cultures superinduced by metabolic inhibitors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118200; DE CLERCQ, E. 1; TORRENCE, P. F. 2; WITKOP, B. 2; STEWART II, W. E. 3; DE SOMER, P. 3; Affiliations: 1: Rega Institute for Medical Research, University of Leuven, Leuven, Belgium; 2: Laboratory of Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 3: Rega Institute for Medical Research; Issue Info: 11/29/1974, Vol. 186 Issue 4166, p835; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Bachrach, Leona L.
T1  - Developing Objectives in Community Mental Health Planning.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1974/12//
VL  - 64
IS  - 12
M3  - Article
SP  - 1162
EP  - 1163
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the conceptual framework for embarking on the design of objectives for a community mental health plan, where a number of administratively independent facilities provide mental health services to the population. Each component unit must determine and submit its own goals and objectives in designing a mental health plan subscribed to by various service organizations. The health plan's objectives should be proposed with due recognition for three characteristics, including relevancy, practicability and measurability.
KW  - Public health
KW  - Goal (Psychology)
KW  - Motivation (Psychology)
KW  - Mental health planning
KW  - Mental health services
KW  - Service industries
KW  - Relevance
KW  - Medical care
KW  - Medical policy
KW  - Community
KW  - Mental health
KW  - Objectives
KW  - Planning
N1  - Accession Number: 7971405; Bachrach, Leona L. 1; Affiliations: 1: Survey and Reports Branch, Division of Biometry, National Institute of Mental Health, 5600 Fishers Lane, Room 18-C-17, Rockville, Maryland 20852; Issue Info: Dec1974, Vol. 64 Issue 12, p1162; Thesaurus Term: Public health; Subject Term: Goal (Psychology); Subject Term: Motivation (Psychology); Subject Term: Mental health planning; Subject Term: Mental health services; Subject Term: Service industries; Subject Term: Relevance; Subject Term: Medical care; Subject Term: Medical policy; Author-Supplied Keyword: Community; Author-Supplied Keyword: Mental health; Author-Supplied Keyword: Objectives; Author-Supplied Keyword: Planning; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 423850 Service Establishment Equipment and Supplies Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Chu, Sherwood C.
AU  - Berman, Mones
T1  - An Exponential Method for the Solution of Systems of Ordinary Differential Equations.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1974/12//
VL  - 17
IS  - 12
M3  - Article
SP  - 699
EP  - 702
SN  - 00010782
AB  - An explicit, coupled, single-step method for the numerical solution of initial value problems for systems of ordinary differential equations is presented. The method was designed to be general purpose in nature but to be especially efficient when dealing with stiff systems of differential equations. it is, in general, second order except for the case of a linear system with constant coefficients and linear forcing terms; in that case, the method is third order. It has been implemented and put to routine usage in biological applications—where stiffness frequently appears—with favorable results. When compared to a standard fourth order Runge-Kutta implementation, computation time required by this method has ranged from comparable for certain nonstiff problems to better than two orders of magnitude faster for some highly stiff systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIFFERENTIAL equations -- Numerical solutions
KW  - EXPONENTIAL functions
KW  - DIFFERENTIAL equations
KW  - CALCULUS
KW  - BOUNDARY value problems
KW  - LINEAR systems
KW  - STIFF computation (Differential equations)
KW  - RUNGE-Kutta formulas
KW  - initial value problems
KW  - numerical solution
KW  - ordinary differential equations
KW  - stiff systems
N1  - Accession Number: 5246460; Chu, Sherwood C. 1 Berman, Mones 1; Affiliation:  1: National Cancer Institute, NIH.; Source Info: Dec1974, Vol. 17 Issue 12, p699; Subject Term: DIFFERENTIAL equations -- Numerical solutions; Subject Term: EXPONENTIAL functions; Subject Term: DIFFERENTIAL equations; Subject Term: CALCULUS; Subject Term: BOUNDARY value problems; Subject Term: LINEAR systems; Subject Term: STIFF computation (Differential equations); Subject Term: RUNGE-Kutta formulas; Author-Supplied Keyword: initial value problems; Author-Supplied Keyword: numerical solution; Author-Supplied Keyword: ordinary differential equations; Author-Supplied Keyword: stiff systems; Number of Pages: 4p; Document Type: Article
L3  - 10.1145/361604.361627
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chu, Sherwood C.
AU  - Berman, Mones
T1  - An Exponential Method for the Solution of Systems of Ordinary Differential Equations.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1974/12//
VL  - 17
IS  - 12
M3  - Article
SP  - 699
EP  - 702
SN  - 00010782
AB  - An explicit, coupled, single-step method for the numerical solution of initial value problems for systems of ordinary differential equations is presented. The method was designed to be general purpose in nature but to be especially efficient when dealing with stiff systems of differential equations. it is, in general, second order except for the case of a linear system with constant coefficients and linear forcing terms; in that case, the method is third order. It has been implemented and put to routine usage in biological applications—where stiffness frequently appears—with favorable results. When compared to a standard fourth order Runge-Kutta implementation, computation time required by this method has ranged from comparable for certain nonstiff problems to better than two orders of magnitude faster for some highly stiff systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIFFERENTIAL equations
KW  - NUMERICAL solutions
KW  - EXPONENTIAL functions
KW  - CALCULUS
KW  - BOUNDARY value problems
KW  - LINEAR systems
KW  - STIFF computation (Differential equations)
KW  - RUNGE-Kutta formulas
KW  - initial value problems
KW  - numerical solution
KW  - ordinary differential equations
KW  - stiff systems
N1  - Accession Number: 5246460; Chu, Sherwood C. 1; Berman, Mones 1; Affiliations: 1: National Cancer Institute, NIH.; Issue Info: Dec1974, Vol. 17 Issue 12, p699; Thesaurus Term: DIFFERENTIAL equations; Subject Term: NUMERICAL solutions; Subject Term: EXPONENTIAL functions; Subject Term: CALCULUS; Subject Term: BOUNDARY value problems; Subject Term: LINEAR systems; Subject Term: STIFF computation (Differential equations); Subject Term: RUNGE-Kutta formulas; Author-Supplied Keyword: initial value problems; Author-Supplied Keyword: numerical solution; Author-Supplied Keyword: ordinary differential equations; Author-Supplied Keyword: stiff systems; Number of Pages: 4p; Document Type: Article
L3  - 10.1145/361604.361627
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Pearlin, Leonard I.
T1  - The World of the Urban Working Class.
JO  - Political Science Quarterly (Academy of Political Science)
JF  - Political Science Quarterly (Academy of Political Science)
Y1  - 1974///Winter74/75
VL  - 89
IS  - 4
M3  - Book Review
SP  - 855
EP  - 856
SN  - 00323195
AB  - Reviewed: The World of the Urban Working Class. Fried, Marc.
KW  - WORKING class
KW  - NONFICTION
KW  - URBAN renewal
KW  - NARRATIVES
KW  - NEIGHBORHOODS
KW  - Fried, Marc
KW  - Massachusetts (Boston, West End)
KW  - FRIED, Marc
KW  - WORLD of the Urban Working Class, The (Book)
N1  - Accession Number: 24245425; Pearlin, Leonard I. 1; Affiliations: 1 : National Institute of Mental Health;  Source Info: Winter74/75, Vol. 89 Issue 4, p855; Note: Publication Information: Lawrence, Mass.: Harvard U. Pr., 1973. 410 pp.; Historical Period: 1950 to 1969; Subject Term: WORKING class; Subject Term: NONFICTION; Subject Term: URBAN renewal; Subject Term: NARRATIVES; Subject Term: NEIGHBORHOODS; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - VAUGHAN, MARY K.
AU  - VAUGHAN, GEORGE M.
AU  - KLEIN, DAVID C.
T1  - Arginine Vasotocin: Effects on Development of Reproductive Organs.
JO  - Science
JF  - Science
Y1  - 1974/12/06/
VL  - 186
IS  - 4167
M3  - Article
SP  - 938
EP  - 939
SN  - 00368075
AB  - Immature 25-day-old mice were injected daily with 1 microgram of arginine vasotocin for 3 or 4 days and killed 24 hours after the last injection. The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glands) were less than half the size of these structures in control males. Similar results were observed when 15-day-old mice were given similar injections and killed 2 weeks after the last injection; furthermore, testis weights were 28 percent smaller than those of controls. It is speculated that arginine vasotocin, which has been found in mammalian pineal glands, might mediate effects of the pineal gland on normal sexual development. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118244; VAUGHAN, MARY K. 1; VAUGHAN, GEORGE M. 1; KLEIN, DAVID C. 1; Affiliations: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 12/ 6/1974, Vol. 186 Issue 4167, p938; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEIGHT, FORREST F.
AU  - PETZOLD, GARY
AU  - GREENGARD, PAUL
T1  - Guanosine 3',5'-Monophosphate in Sympathetic Ganglia: Increase Associated with Synaptic Transmission.
JO  - Science
JF  - Science
Y1  - 1974/12/06/
VL  - 186
IS  - 4167
M3  - Article
SP  - 942
EP  - 944
SN  - 00368075
AB  - Brief stimulation of cholinergic preganglionic nerve fibers resulted in an increase in guanosine 3',5'-monophosphate (cyclic GMP) in the bullfrog sympathetic ganglion. When the release of synaptic transmitter was prevented by a high-magnesium, low-calcium Ringer solution, stimulation of preganglionic nerve fibers did not increase cyclic GMP in the ganglion. The increase in cyclic GMP caused by preganglionic stimulation was also blocked by the muscarinic antagonist, atropine. The data indicate that the increase in cyclic GMP is associated with synaptic transmission and support the possibility that cyclic GMP may mediate the postsynaptic action of acetylcholine at muscarinic cholinergic synapses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118247; WEIGHT, FORREST F. 1; PETZOLD, GARY 2; GREENGARD, PAUL 2; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510; Issue Info: 12/ 6/1974, Vol. 186 Issue 4167, p942; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Carman, J. S.;
AU  - Post, R. M.;
AU  - Teplitz, T. A.;
AU  - Goodwin, F. K.;
T1  - Divalent cations in predicting antidepressant response to lithium
CT  - Divalent cations in predicting antidepressant response to lithium
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1974/12/14/
VL  - 2
IS  - Dec 14
SP  - 1454
SN  - 00237507
AD  - Adult Psychiatry Branch and Section on Psychiatry, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 12-3191; Language: English; Chemical Name: Lithium--7439-93-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium; References: 19; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - Results of preliminary studies in patients have shown that the pre-treatment calcium/magnesium ratio was significantly related to the subsequent antidepressant response to lithium.
KW  - Lithium--therapy-;
KW  - Psychotherapeutic agents--lithium--therapy, response, effects of pretreatment calcium/magnesium, in patients;
KW  - Methodology--lithium--therapy, response, effects of pretreatment calcium/magnesium ratio, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Dekaban, A. S.;
AU  - Steusing, J. K.;
T1  - Menkes' kinky hair disease treated with subcutaneous copper sulfate
CT  - Menkes' kinky hair disease treated with subcutaneous copper sulfate
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1974/12/21/
VL  - 2
IS  - Dec 21
SP  - 1523
SN  - 00237507
AD  - Developmental and Metabolic Neurology Branch, N.I.N.D.S., National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-2372; Language: English; Chemical Name: Cupric sulfate--7758-99-8; References: 8; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - The treatment of Menkes' kinky hair disease in 2 infants using a SC infusion of 1-2 mg of copper sulfate in 25-50 ml of saline (0.04 mg/ml) is reported. The infusions were given by slow-drip over 2 hours. The infusions were administered every 3-4 days in 4 alternate sites. No untoward local effects or complications were encountered during 5 months of this therapy.
KW  - Cupric sulfate--Menkes' kinky hair disease-;
KW  - Drug administration--routes--cupric sulfate, SC infusion, Menkes' disease, in infants;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P. S.;
AU  - Winokur, S. K.;
T1  - Immunosuppressive and cytotoxic chemotherapy: long term complications
CT  - Immunosuppressive and cytotoxic chemotherapy: long term complications
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1975/01/01/
VL  - 82
IS  - Jan
SP  - 84
EP  - 95
SN  - 00034819
AD  - Reprints: Div. of Medical Oncology, Georgetown Univ. Hospital, Washington, D.C. 20007
AD  - Clinical Pharmacology-Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-5486; Language: English; References: 160; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Patrick Moran
N2  - Complications of long term immunosuppressive and cytotoxic chemotherapy in patients are reviewed. The primary complication is cumulative organ toxicity which is often insidious in onset and which may not be apparent clinically until the damage has become severe and irreversible.
KW  - Immunosuppressive agents--toxicity--long term, review, in patients;
KW  - Antineoplastic agents--toxicity--long term, review, in patients;
KW  - Toxicity--immunosuppressive agents--long term, review, in patients;
KW  - Toxicity--antineoplastic agents--long term, review, in patients;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5486&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Merrill, J.;
AU  - Grezo, A. F.;
AU  - Zimbler, H.;
AU  - Brereton, H. D.;
AU  - Lamberg, J. D.;
AU  - \ET/;
T1  - Adriamycin and radiation: synergistic cardiotoxicity
CT  - Adriamycin and radiation: synergistic cardiotoxicity
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1975/01/01/
VL  - 82
IS  - Jan
SP  - 122
EP  - 123
SN  - 00034819
AD  - Radiation Oncology Branch, Div. of Cancer Biology and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-5848; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 4; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Patrick Moran
N2  - Severe cardiomyopathy with irreversible congestive heart failure is reported in 2 children being treated with 500 to 550 mg/sq m adriamycin (doxorubicin) in conjunction with therapeutic radiation to the thoracic spine and lungs. It is suggested that a synergistic radiation-adriamycin cardiotoxicity is possible in patients receiving such therapy.
KW  - Doxorubicin--interactions-;
KW  - Radiation--interactions--doxorubicin, cardiotoxicity, in children;
KW  - Drug interactions--doxorubicin and radiation--cardiotoxicity, in children;
KW  - Drug interactions--radiation and doxorubicin--cardiotoxicity, in children;
KW  - Antineoplastic agents--doxorubicin--interactions, radiation, cardiotoxicity, in children;
KW  - Toxicity--doxorubicin--and radiation, cardiotoxcity, in children;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5848&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pomeroy, T. C.;
AU  - Johnson, R. E.;
T1  - Combined modality therapy of Ewing's sarcoma
CT  - Combined modality therapy of Ewing's sarcoma
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1975/01/01/
VL  - 35
IS  - Jan
SP  - 36
EP  - 47
AD  - Radiation Branch, DCBD, National Cancer Institute, Bldg. 10, Rm. R3B38, Bethesda, Maryland 20014
N1  - Accession Number: 12-4886; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8 Cyclophosphamide--6055-19-2 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents cyclophosphamide and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine and cyclophosphamide; References: 33; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Michael M. Alexander
N2  - The management of Ewing's sarcoma by the use of aggressive adjunctive chemotherapy in 66 patients is discussed. Therapy consisted of local irradiation of the primary site combined with adjuvant regimens of progressively more intense systemic chemotherapy. Actuarial survival rates for the total series show a 56% 2-year survival and a 35% 5-year survival. The 43 patients with clinically detectable metastases had a better survival rate. The current protocol included alternating high doses of adriamycin (doxorubicin) with cyclophosphamide plus vincristine and provided improved disease-free survival as compared with previous protocols.
KW  - Doxorubicin--Ewing's sarcoma-;
KW  - Cyclophosphamide--and vincristine-;
KW  - Vincristine--and cyclophosphamide-;
KW  - Antineoplastic agents--doxorubicin--and cyclophosphamide and vincristine, alternately, therapy, with radiation in Ewing's sarcoma patients;
KW  - Antineoplastic agents--cyclophosphamide and vincristine--and doxorubicin, alternately, therapy, with radiation in Ewing's sarcoma patients;
KW  - Combined therapy--cyclophosphamide and vincristine--and doxorubicin, alternately, with radiation in Ewing's sarcoma patients;
KW  - Combined therapy--vincristine and cyclophosphamide--and doxorubicin, alternately, with radiation in Ewing's sarcoma patients;
KW  - Antineoplastic agents--vincristine and cyclophosphamide--and doxorubicin, alternately, therapy, with radiation in Ewing's sarcoma patients;
KW  - Antineoplastic agents--radiation--and doxorubicin, alternately with cyclophosphamide and vincristine, therapy, Ewing's sarcoma patients;
KW  - Radiation--Ewing's sarcoma--and doxorubicin, alternately with cyclophosphamide and vincristine, therapy, in patients;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4886&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T.;
AU  - Young, R. C.;
AU  - Canellos, G. P.;
T1  - Combination versus single agent chemotherapy: review of the basis for selection of drug treatment of cancer
CT  - Combination versus single agent chemotherapy: review of the basis for selection of drug treatment of cancer
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1975/01/01/
VL  - 35
IS  - Jan
SP  - 98
EP  - 10
AD  - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-4386; Language: English; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
KW  - Rational therapy--antineoplastic agents--combined, comparison, single agent, discussion, in patients;
KW  - Antineoplastic agents--rational therapy--combined, comparison, single agent, discussion, in patients;
KW  - Combined therapy--antineoplastic agents--comparison, single agents, rational therapy, discussion, in patients;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4386&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Friedman, R B
AU  - Pestaner, L C
AU  - Young, D.s.
T1  - Laboratory oriented computerized drug information systems
JO  - Drug Information Journal 9, 182-189 (1975 May-september). 6 Ref
JF  - Drug Information Journal 9, 182-189 (1975 May-september). 6 Ref
Y1  - 1975///
M3  - Book Chapter
AB  - The structure and uses of the computerized listing of abnormal and unusual drug effects (claude), developed by the national institutes of health, are discussed. Claude was developed to facilitate the correct interpretation of laboratory data by physicians and clinical laboratory scientists. The data base contains approximately 17,500 effects, both in vivo and in vitro, for 1500 drugs on laboratory tests.
N1  - Accession Number: ISTA1200298; Friedman, R B 1; Pestaner, L C; Young, D.s. 1; Affiliations: 1 : Clinical Pathology Department, National Institutes Of Health, Bethesda, Maryland;  Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Bellicha, T C
T1  - Targeted information concept. the national clearinghouse for alcohol information
JO  - Drug Information Journal 9, 199-205 (1975 May-september)
JF  - Drug Information Journal 9, 199-205 (1975 May-september)
Y1  - 1975///
M3  - Book Chapter
AB  - The purpose, organization, and operation of the services of the national clearinghouse for alcohol information are detailed. Problems in the acquisition, classification, and dissemination of alcohol related information are discussed, as well as methods of identifying potential users of this specialized collection.
N1  - Accession Number: ISTA1200384; Bellicha, T C 1; Affiliations: 1 : National Institute On Alcohol Abuse And Alcoholism, Gaithersburg, Maryland;  Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1200384&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Leeds, A A
T1  - International reference centers network-an unusual information resource
JO  - Drug Information Journal 9, 219-223 (1975 May-september)
JF  - Drug Information Journal 9, 219-223 (1975 May-september)
Y1  - 1975///
M3  - Book Chapter
AB  - The organization, publications, and activities of the international reference centers network for information on psychotropic drugs are discussed as a model system for international cooperation in the exchange of scientific information.
N1  - Accession Number: ISTA1200998; Leeds, A A 1; Affiliations: 1 : International Reference Center For Information On Psychotropic Drugs, National Institute Of Mental Health, Rockville, Maryland;  Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 
TY  - JOUR
AU  - Makinodan, Takashi
T1  - Will revitalized cells perk up immune activity in older persons?
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1975/01//
VL  - 30
IS  - 1
M3  - Article
SP  - 35
EP  - 37
SN  - 0016867X
N1  - Accession Number: 17729114; Makinodan, Takashi 1; Source Information: Jan1975, Vol. 30 Issue 1, p35; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 893
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17729114&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Davis, Howard R
AU  - Salasin, Susan E
T1  - The utilization of evaluation
JO  - In Struening, Elmer L.: Guttentag, Marcia. Handbook Of Evaluation Research. Vol. 1. 1975. Sage Publications, Inc., Beverly Hills, California. P. 621-666. 69 Ref. See Isa 77-3957/y
JF  - In Struening, Elmer L.: Guttentag, Marcia. Handbook Of Evaluation Research. Vol. 1. 1975. Sage Publications, Inc., Beverly Hills, California. P. 621-666. 69 Ref. See Isa 77-3957/y
Y1  - 1975///
M3  - Book Chapter
AB  - The winds and currents, the array of forces, impinging on evaluation utilization are examined. An approach to predicting their influence on a given evaluation is considered, and a guideline for use by evaluators who may wish to enhance their contributions to the destinies of the cause they serve is proposed. It is held that: 1) evaluation provides great hope for ultimate beneficiaries of social programs; 2) effective utilization of evaluation is essential; 3) the destines of evaluation are, to some extent, predictable; 4) evaluators should consider extending their role to change consultation; 5) one's professional services can be based on a vast body of information on change and models of conceptualization; 6) utilization of evaluation may be achieved through the human approach to organizational change; 7) a victory technique may represent a schema to consider in trying the evaluator change consultant role.
N1  - Accession Number: ISTA1203608; Davis, Howard R 1; Salasin, Susan E; Affiliations: 1 : National Institute Of Mental Health;  Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hoel, D. G.;
AU  - Gaylor, D. W.;
AU  - Kirschstein, R. L.;
AU  - Saffiotti, U.;
AU  - Schneiderman, M. A.;
T1  - Estimation of risks of irreversible delayed toxicity
CT  - Estimation of risks of irreversible delayed toxicity
JO  - J. Toxicol. Environ. Health
JF  - J. Toxicol. Environ. Health
Y1  - 1975/01/01/
VL  - 1
IS  - Jan
SP  - 133
EP  - 151
AD  - National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina
N1  - Accession Number: 13-2397; Language: English; References: 29; Publication Type: Review; Journal Coden: JTEHD6; Section Heading: Methodology
N2  - The current statistical methods used to establish dose-response relationships for irreversible self-replicating toxic effects (i.e., carcinogenesis) in laboratory animals and extrapolation of these data to man are reviewed. The method or procedure for estimating human risk based on animal studies is basically carried out in 4 sequential steps: (1) Design and/or assessment of laboratory experiments as to quality and biological appropriateness; (2) statistical extrapolation of the experimental results to low dose levels; (3) extrapolation of the estimated results in animals at the low level to man; and (4) assessment of the risk to man based upon experimental data. Information about each of these steps is discussed as is the type of research to improve the quality of the entire statistical procedure.
KW  - Methodology--toxicity--statistics, review;
KW  - Statistics--toxicity--methodology, review;
KW  - Toxicity--statistics--methodology, review;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-2397&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rall, D. P.;
T1  - Candidate drugs for carcinogenic property studies: procedures
CT  - Candidate drugs for carcinogenic property studies: procedures
JO  - Journal of Clinical Pharmacology (USA)
JF  - Journal of Clinical Pharmacology (USA)
Y1  - 1975/01/01/
VL  - 15
IS  - Jan
SP  - 1
EP  - 4
SN  - 00912700
AD  - National Institute of Environmental Health Sciences, NIH Research Triangle Park, North Carolina 27709
N1  - Accession Number: 13-1781; Language: English; References: 4; Journal Coden: JCPCBR; Section Heading: Methodology; Abstract Author: Walter Howard
N2  - New drugs are needed, and with respect to carcinogenesis, quick presumptive tests must be developed which will enable us to rapidly identify those compounds that are most likely to cause trouble. Closer attention to toxicity studies may enable the researcher to pick up hints about compounds that may have a carcinogenic effect. Lifetime rodent studies on all drugs in clinical usage are needed, and a much more advanced adverse drug reaction surveillance system should be implemented, including a record linkage system which allows patient followup, with those patients who have been exposed to the drugs in question. If programs like this can be developed over the next few years, the output of valuable new agents will be increased and, at the same time, it will be possible to reduce or minimize the danger to the patient.
KW  - Methodology--toxicity--tests, carcinogenicity, drugs, new, and those in clinical practice;
KW  - Toxicity--drugs--carcinogens, new, and those in clinical practice;
KW  - Carcinogens--tests--methodology, drugs, new and those in clinical practice;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-1781&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Weisburger, E. K.;
T1  - Critical evaluation of the methods used for determining carcinogenicity
CT  - Critical evaluation of the methods used for determining carcinogenicity
JO  - Journal of Clinical Pharmacology (USA)
JF  - Journal of Clinical Pharmacology (USA)
Y1  - 1975/01/01/
VL  - 15
IS  - Jan
SP  - 5
EP  - 5
SN  - 00912700
AD  - Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-2111; Language: English; Chemical Name: Azathioprine--446-86-6 Cyclophosphamide--6055-19-2 Methotrexate--59-05-2; References: 76; Publication Type: Review; Journal Coden: JCPCBR; Section Heading: Methodology
N2  - Methods currently employed for evaluating the possible carcinogenic potential of environmental compounds and contemporary antineoplastic agents, including, cyclophosphamide, azathioprine, and methotrexate, have been reviewed.
KW  - Azathioprine--methodology-;
KW  - Cyclophosphamide--methodology-;
KW  - Methotrexate--methodology-;
KW  - Carcinogens--methodology--review;
KW  - Toxicity, environmental--carcinogens--methodology, review;
KW  - Methodology--carcinogens--review;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-2111&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hoover, R.;
AU  - Fraumeni, J. F.;
T1  - Drugs in clinical use which cause cancer
CT  - Drugs in clinical use which cause cancer
JO  - Journal of Clinical Pharmacology (USA)
JF  - Journal of Clinical Pharmacology (USA)
Y1  - 1975/01/01/
VL  - 15
IS  - Jan
SP  - 16
EP  - 23
SN  - 00912700
AD  - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-1782; Language: English; References: 51; Journal Coden: JCPCBR; Human Indicator: Yes; Section Heading: Methodology; Abstract Author: Walter Howard
N2  - As different conditions are added to therapeutic indications for currently used drugs, new assessments of their carcinogenic potential must be made. Carcinogenicity tests have become much more advanced and accurate. It seems likely that some decisions about carcinogenic potential of drugs can now be made on the basis of expertise provided by laboratory scientists and epidemiologists, rather than waiting for long term human effects to appear.
KW  - Methodology--toxicity--carcinogens, drugs, studies;
KW  - Toxicity--carcinogens--studies, methodology;
KW  - Carcinogens--drugs--studies, methodology;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-1782&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Korn, Edward D
T1  - Availability of grant applications
JO  - Science 190(4216), 736 (1975 November 21). 0 Ref. See Isa 76-803/r
JF  - Science 190(4216), 736 (1975 November 21). 0 Ref. See Isa 76-803/r
Y1  - 1975///
M3  - Book Chapter
AB  - In the wake of district of columbia court of appeals decision permitting scientists access to research grant applications of others under the freedom of information act, the author urges colleagues on the nih/nimh (national institutes of health/national institute of mental health) staff to abstain voluntarily from requesting grant application copies, because of adverse effects on the peer review system and on research progress.
N1  - Accession Number: ISTA1100741; Korn, Edward D 1; Affiliations: 1 : Inter-assembly Council, National Institutes Of Health/national Institutes Of Mental Health;  Source Info: 1975; Note: Update Code: 1100; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2006-06270-018
AN  - 2006-06270-018
AU  - Yarrow, Leon J.
T1  - Child Development, Psychodynamics, and the Law.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1975/01//
VL  - 20
IS  - 1
SP  - 25
EP  - 27
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06270-018. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Foster Parents; Laws; Psychodynamics. Minor Descriptor: Child Custody. Classification: Childrearing & Child Care (2956); Civil Rights & Civil Law (4210). Population: Human (10). Reviewed Item: Goldstein, Joseph; Freud, Anna; Solnit, Albert J. Beyond the Best Interests of the Child=New York: Free Press, 1973. Pp. xiii + 176. $7.95 cloth; $1.95 paper; 1973. Page Count: 3. Issue Publication Date: Jan, 1975. 
AB  - Reviews the book, Beyond the Best Interests of the Child by Joseph Goldstein, Anna Freud, and Albert J. Solnit (see record [rid]1974-10899-000[/rid]). Considers the nature of the relationship between the child and the custodian, whether biological, psychological, adoptive, or foster parent. Data concerning the child's sense of time and need for continuity of relationships are discussed. Guidelines and their implications for the laws of child placement are presented. The authors attempt to translate psychodynamic principles of growth and development into procedural guides for making decisions about a child's placement in foster care, adoption, or custody in divorce proceedings. The clarity and succinctness of this book are refreshing and make for easy reading. It has, however, a deceptive quality of simplicity The economy of words leaves much to interpretation; there is too little elaboration of controversial ideas. This stimulating essay opens up many important issues, but it is only a beginning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - foster parents
KW  - laws
KW  - psychodynamics
KW  - 1975
KW  - Foster Parents
KW  - Laws
KW  - Psychodynamics
KW  - Child Custody
KW  - 1975
U2  - Goldstein, Joseph; Freud, Anna; Solnit, Albert J. (1973); Beyond the Best Interests of the Child; New York: Free Press, 1973. Pp. xiii + 176. $7.95 cloth; $1.95 paper
DO  - 10.1037/0013019
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06270-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 83985710
T1  - Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti's syndrome) to Angiosarcomas.
AU  - Thomas, Louis B.
AU  - Popper, Hans
AU  - Berk, Paul D.
AU  - Selikoff, Irving
AU  - Falk, Henry
AU  - Thomas, L B
AU  - Popper, H
AU  - Berk, P D
AU  - Selikoff, I
AU  - Falk, H
Y1  - 1975/01/02/
N1  - Accession Number: 83985710. Language: English. Entry Date: 20160507. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Hypersplenism -- Chemically Induced
KW  - Occupational Diseases
KW  - Liver Neoplasms -- Chemically Induced
KW  - Vinyl Compounds -- Adverse Effects
KW  - Hypertension, Portal -- Chemically Induced
KW  - Sarcoma -- Chemically Induced
KW  - Sarcoma -- Pathology
KW  - Splenomegaly -- Pathology
KW  - Hypertrophy
KW  - Liver Neoplasms -- Pathology
KW  - Occupational Diseases -- Pathology
KW  - Spleen -- Pathology
KW  - Hypertension, Portal -- Pathology
KW  - Hypersplenism -- Pathology
KW  - Environmental Exposure
KW  - Liver Cirrhosis -- Chemically Induced
KW  - Hydrocarbons, Chlorinated -- Adverse Effects
KW  - Hyperplasia
KW  - Biopsy
KW  - Autopsy
KW  - Liver Cirrhosis -- Pathology
KW  - Time Factors
KW  - Polyvinyls -- Adverse Effects
KW  - Liver -- Pathology
SP  - 17
EP  - 22
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 292
IS  - 1
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - Histologic examination of liver tissue (eight autopsy and 18 biopsy specimens) and five spleens from 20 workers with vinyl chloride polymerization showed hepatic angiosarcomas in 15. In addition, a peculiar pattern of progressive portal-tract, inconspicuous intralobular and conspicuous capsular fibrosis was observed in the five workers without angiosarconma, in all the seven patients with angiosarcoma from whom tumor-free portions of the liver were available, and in two tumor-free biopsies from patients subsequently found to have angiosarcoma. The fibrosis was accompanied by splenomegaly. Hypertrophy and hyperplasia of both hepatocytes and hepatic and splenic mesenchymal cells were also seen. The histologic similarity to chronic inorganic arsenical poisoning, in which angiosarcomas also occur, and to idiopathic portal hypertension (Banti's syndrome) suggests that the latter syndrome at times results from unknown toxic, possible environmental, chemicals.
SN  - 0028-4793
AD  - From the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, the Mount Sinai School of Medicine of the City University of New York, NY, the Section on Diseases of the Liver, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, MD, and the Cancer and Birth Defects Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, GA (address reprint requests to Dr. Thomas at the National Cancer Institute, Bldg 10, Room 2A29, Bethesda, MD 20014).
U2  - PMID: 1167315.
DO  - 10.1056/NEJM197501022920104
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=83985710&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Thomas, L. B.;
AU  - Popper, H.;
AU  - Berk, P. D.;
AU  - Selikoff, I.;
AU  - Falk, H.;
T1  - Vinyl chloride induced liver disease
CT  - Vinyl chloride induced liver disease
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1975/01/02/
VL  - 292
IS  - Jan 2
SP  - 17
EP  - 21
SN  - 00284793
AD  - National Cancer Institute, Bldg. 10, Rm. 2A29, Bethesda, Maryland 20014
N1  - Accession Number: 12-3331; Language: English; Chemical Name: Vinyl chloride--75-01-4; References: 32; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2  - Histologic examination of liver tissue (8 autopsy and 18 biopsy specimens) and 4 spleens from 20 workers with vinyl chloride polymerization showed hepatic angiosarcomas in 15. In addition, a peculiar pattern of progressive portal tract, inconspicuous intralobular and conspicuous capsular fibrosis was observed in the 5 workers without angiosarcoma, in all the 7 patients with angiosarcoma from whom tumor free portions of the liver were available, and in 2 tumor free biopsies from patients subsequently found to have angiosarcoma. The fibrosis was accompanied by splenomegaly. Hypertrophy and hyperplasia of both hepatocytes and hepatic and splenic mesenchymal cells were also seen. The histologic similarity to chronic inorganic arsenical poisoning, in which angiosarcomas also occur, and to idiopathic portal hypertension (Banti's syndrome) suggests that the latter syndrome at times results from unknown toxic, possibly environmental, chemicals.
KW  - Vinyl chloride--toxicity, environmental-;
KW  - Toxicity, environmental--vinyl chloride--angiosarcomas, hepatic, in humans;
KW  - Polymers--vinyl chloride--angiosarcomas, hepatic, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - GALLAGHER, ROBERT E.
AU  - GALLO, ROBERT C.
T1  - Type C RNA Tumor Virus Isolated from Cultured Human Acute Myelogenous Leukemia Cells.
JO  - Science
JF  - Science
Y1  - 1975/01/31/
VL  - 187
IS  - 4174
M3  - Article
SP  - 350
EP  - 353
SN  - 00368075
AB  - Previously, type C RNA tumor virus-related components have been described in blood leukocytes from patients with acute myelogenous leukemia. These components, for example, reverse transcriptase, have been shown to be most closely related to those from two oncogenic subhuman primate type C viruses (woolly monkey sarcoma virus and gibbon ape leukemia virus). Now, we report the continuous production of budding type C viruses with the same characteristic reverse transcriptase by three separate culturings of leukocytes from a single bleeding from a patient with acute myelogenous leukemia. These isolations were made possible by the discovery of a source of conditioned media which sustains exponential growth of human myelogenous leukemia cells in liquid suspension culture. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118459; GALLAGHER, ROBERT E. 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/31/1975, Vol. 187 Issue 4174, p350; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WYATT, R. J.
AU  - SCHWARTZ, M. A.
AU  - ERDELYI, E.
AU  - BARCHAS, J. D.
T1  - Dopamine β-Hydroxylase Activity in Brains of Chronic Schizophrenic Patients.
JO  - Science
JF  - Science
Y1  - 1975/01/31/
VL  - 187
IS  - 4174
M3  - Article
SP  - 368
EP  - 370
SN  - 00368075
AB  - Postmortem brain specimens from nine chronic schizophrenic patients and nine controls were assayed for activity of dopamine, 8-hydroxylase, the enzyme responsible for the conversion of dopamine to norepinephrine. Unlike the results of previous reports, there was no statistically significant difference in enzyme activity between the patient and control groups. There were, however, significant negative correlations between dopamine βhydroxylase activity and the time spent in the morgue before autopsy, and between enzyme activity of schizophrenics and dosage of chlorpromazine or its equivalent. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85118467; WYATT, R. J. 1; SCHWARTZ, M. A. 1; ERDELYI, E. 2; BARCHAS, J. D. 2; Affiliations: 1: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Laboratory of Behavioral Neurochemistry, Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305; Issue Info: 1/31/1975, Vol. 187 Issue 4174, p368; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Rieder, R. O.;
AU  - Rosenthal, D.;
AU  - Wender, P.;
AU  - Blumenthal, H.;
T1  - Offsprings of schizophrenics
CT  - Offsprings of schizophrenics
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1975/02/01/
VL  - 32
IS  - Feb
SP  - 200
EP  - 211
AD  - National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 13-1427; Language: English; References: 22; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - In this report on neurological development among the offspring of schizophrenics, it was stated that genotype of the child, adverse intrauterine environment, and medication toxicity should be considered.
KW  - Psychotherapeutic agents--schizophrenia--placental transfer, fetal effects, in offspring, following administration during pregnancy;
KW  - Toxicity--psychotherapeutic agents--placental transfer, fetal effects, in offspring, following maternal administration during pregnancy for schizophrenia;
KW  - Placental transfer--psychotherapeutic agents--effects, fetal, in offspring, following administration during pregnancy for schizophrenia;
KW  - Metabolism--psychotherapeutic agents--placental transfer, fetal effects, in offspring, following administration during pregnancy for schizophrenia;
KW  - Teratogenicity--psychotherapeutic agents--placental transfer, fetal effects, in offspring, following administration during pregnancy for schizophrenia;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P. S.;
AU  - Chabner, B. A.;
AU  - Canellos, G. P.;
AU  - Young, R. C.;
AU  - DeVita, V. T.;
T1  - Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy
CT  - Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1975/02/01/
VL  - 35
IS  - Feb
SP  - 354
EP  - 357
AD  - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-5816; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Cyclophosphamide--6055-19-2 Vincristine--57-22-7 Prednisone--53-03-2 Mechlorethamine--51-75-2 Procarbazine--671-16-9; References: 12; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jimmy H. Knowles
N2  - An analysis of patterns of relapse from complete remissions of non-Hodgkin's lymphoma treated with 3 combination chemotherapy regimens is presented. Three basic treatment programs were employed. (1) A cyclical combination protocol consisted of cyclophosphamide, 400 mg/sq m/day orally for 5 days; vincristine, 1.4 mg/sq m IV on day 1; and prednisone, 100 mg/sq m/day orally for 5 days; repeated every 21 days. When a complete remission status was achieved after a minimum of 4 cycles, 2 additional consolidation cycles were administered. This regimen was used in the treatment of all patients with lymphocytic and in half the cases with mixed histiocytic-lymphocytic lymphoma. Regimens (2) and (3) were administered in 6 monthly courses and were used in the treatment of patients with histiocytic and half of the cases with mixed histiocytic-lymphocytic lymphoma. (2) MOPP consisted of nitrogen mustard (mechlorethamine), 6 mg/sq m IV on days 1 and 8; vincristine, 1.4 mg/sq m IV on days 1 and 8; procarbazine, 100 mg/sq m/day orally for 14 days; and prednisone, 40 mg/sq m/day orally for 14 days. (3) C-MOPP was a modified regimen that substituted cyclophosphamide 650 mg/sq m IV on days 1 and 8 in the place of nitrogen mustard.
KW  - Cyclophosphamide--combined therapy-;
KW  - Vincristine--combined therapy-;
KW  - Prednisone--combined therapy-;
KW  - Mechlorethamine--combined therapy-;
KW  - Procarbazine--combined therapy-;
KW  - Antineoplastic agents--combined therapy--lymphomas, non-Hodgkin, in patients;
KW  - Combined therapy--antineoplastic agents--lymphomas, non-Hodgkin, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Catalona, W. J.
AU  - Tarpley, J. L.
AU  - Potvin, C.
AU  - Chretien, P. B.
T1  - CORRELATIONS AMONG CUTANEOUS REACTIVITY TO DNCB, PHA-INDUCED LYMPHOCYTE BLASTO-GENESIS AND PERIPHERAL BLOOD E ROSETTES.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1975/02//
VL  - 19
IS  - 2
M3  - Article
SP  - 327
EP  - 333
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PFIA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded statistically significant positive correlations between the DNCB and PHA assays in twenty-one of twenty-eight instances, the DNCB and E rosette assays in thirteen of sixteen instances, the PHA and E rosette assays in twenty- eight of thirty-six instances, and among the DNCB, PHA and E rosette assays in ten of fourteen instances. The results suggest that both PHA-stimulated lymphocyte blastogenesis and peripheral blood E rosette-forming lymphocyte levels provide meaningful in vitro correlates of cell-mediated immunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DINITROCHLOROBENZENE
KW  - IMMUNE system
KW  - POLY-beta-hydroxyalkanoates
KW  - SKIN diseases
KW  - CONTACT dermatitis
KW  - BLASTOGENESIS (Embryology)
N1  - Accession Number: 15945650; Catalona, W. J. 1,2 Tarpley, J. L. 2 Potvin, C. 2,3 Chretien, P. B. 2; Affiliation:  1: Brady Research Laboratory, The John Hopkins Hospital, Baltimore, Maryland.  2: Tumor Immunology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: McEachren Fellow, Canadian Cancer Society.; Source Info: Feb1975, Vol. 19 Issue 2, p327; Subject Term: DINITROCHLOROBENZENE; Subject Term: IMMUNE system; Subject Term: POLY-beta-hydroxyalkanoates; Subject Term: SKIN diseases; Subject Term: CONTACT dermatitis; Subject Term: BLASTOGENESIS (Embryology); Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Meyer, T.J.
AU  - Azuma, I.
AU  - Ribi, A.
T1  - Biologically Active Components from Mycobacterial Cell Walls.
JO  - Immunology
JF  - Immunology
Y1  - 1975/02//
VL  - 28
IS  - 2
M3  - Article
SP  - 219
EP  - 229
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The efficacy of various fractions of mycobacterial cell walls in producing experimental allergic encephalomyelitis (EAE) has been evaluated. BCG (Bacillus- Calmette-Guérin) cell walls were effective in producing EAE in all animals at dose levels as low as 40 μg. Study of subfractions of these cell walls revealed the following: (1) wax D was active, but required larger doses than BCG cell walls; (2) the chloroform-methanol-soluble (CMS) portion of wax D and P3 (a mycolic acid-trehalose ester contained therein) were inactive; (3) the chloroform-methanol- insoluble (CMI) portion of wax D was active; (4) exhaustively delipidated cell wall skeletons of BCG, Nocardia asteroides, Mycobacterium smegmatis, Corynebacterium diphtheriae and M. konsasii were active; (5) two water-soluble adjuvants prepared from mycobacteria were active. These results suggest that the mycobacterial structure responsible for EAE adjuvanticity is present in the organic solvent-insoluble cell wall skeleton framework. The activity of wax D may be due to the presence of cell-wall skeleton constituents which are found in varying quantity in most wax D preparations. Wax D components soluble in a solution of chloroforrn:methanol (diluted 2:1 v/v) do not produce EAE. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALLERGIC encephalomyelitis
KW  - MYCOBACTERIA
KW  - BACTERIAL cell walls
KW  - BCG vaccination
KW  - AUTOIMMUNE diseases
KW  - GUINEA pigs
KW  - IMMUNIZATION
N1  - Accession Number: 13370882; Meyer, T.J. 1 Azuma, I. 1 Ribi, A. 1; Affiliation:  1: U.S. Department of Health, Education, and Welfare, Public Health Service, National lnstitutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Feb75, Vol. 28 Issue 2, p219; Subject Term: ALLERGIC encephalomyelitis; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL cell walls; Subject Term: BCG vaccination; Subject Term: AUTOIMMUNE diseases; Subject Term: GUINEA pigs; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pennington, J. E.;
AU  - Reynolds, H. Y.;
T1  - Pharmacokinetics of gentamicin in bronchial secretions
CT  - Pharmacokinetics of gentamicin in bronchial secretions
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1975/02/01/
VL  - 131
IS  - Feb
SP  - 158
EP  - 161
SN  - 00221899
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Building 10, Room 11B-13, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-5653; Language: English; Chemical Name: Gentamicin--1403-66-3; References: 26; Journal Coden: JIDIAQ; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Robert Barger
N2  - The rate of appearance, peak concentrations, and rate of clearance of gentamicin in bronchial secretions of dogs was studied by using rapid IV infusion and IM injection. A 10 min infusion of 1.7 mg/kg or 2 divided doses of 0.85 mg/kg each in 4 hr were given to dogs with simultaneous blood and bronchial specimens collected at specific intervals after administration. IV infusion produced levels of greater than 3meq/ml in bronchial secretions for approximately 100 min but the drug was cleared from respiratory secretions within 3 hr. IM injection gave low but more sustained bronchial levels. The minimum inhibitory concentration of gentamicin needed should be considered when the dose or frequency of parenteral gentamicin is ordered.
KW  - Gentamicin--pharmacokinetics-;
KW  - Pharmacokinetics--gentamicin--intramuscular, and IV, bronchial secretion levels, in dogs;
KW  - Drugs, body distribution--gentamicin--intramuscular, and IV, bronchial secretion levels, in dogs;
KW  - Metabolism--gentamicin--intramuscular, and IV, bronchial secretion levels, in dogs;
KW  - Drug administration--routes--gentamicin, IM and IV, bronchial secretion levels, in dogs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Hearing, Vincent J.
AU  - Ekel, Thomas M.
T1  - INVOLVEMENT OF TYROSINASE IN MELANIN FORMATION IN MURINE MELANOMA.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/02//
VL  - 64
IS  - 2
M3  - Article
SP  - 80
EP  - 85
SN  - 0022202X
AB  - The possibility that peroxidase is functional in melanogenesis in the murine S-91 melanoma has been investigated. It was found that, as in the normal mouse, tyrosinase is the enzyme responsible for the bulk of melanin formation in the malignant melanocyte. Tyrosinase was capable of utilizing tyrosine as a substrate, as well as dopa, although the Vmax with dopa was much higher than with tyrosine. Conversely, the affinity of the enzyme for tyrosine is higher than for dopa, and this relationship may in part be responsible for the occasional misinterpretation of the functional capability of this enzyme. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOGENESIS
KW  - TYROSINE
KW  - MELANOMA
KW  - ENZYMES
KW  - DOPA
KW  - CANCER
N1  - Accession Number: 12510302; Hearing, Vincent J. 1 Ekel, Thomas M. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland.; Source Info: Feb75, Vol. 64 Issue 2, p80; Subject Term: MELANOGENESIS; Subject Term: TYROSINE; Subject Term: MELANOMA; Subject Term: ENZYMES; Subject Term: DOPA; Subject Term: CANCER; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12510302
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levis, William R.
AU  - Whalen, John J.
AU  - Powell, John A.
T1  - STUDIES ON THE CONTACT SENSITIZATION OF MAN WITH SIMPLE CHEMICALS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/02//
VL  - 64
IS  - 2
M3  - Article
SP  - 100
EP  - 104
SN  - 0022202X
AB  - Dinitrochlorobenzene (DNCB) coupled to peripheral blood erythrocytes or leukocytes forms a particulate complex, DNCB-antigen. The addition of DNCB-antigen induced blastogenesis and DNA synthesis in leukocyte cultures from DNCB-sensitized human subjects and not in leukocyte cultures from nonsensitized controls. In general, sensitized subjects who displayed a higher degree of cutaneous reactivity to DNCB, as manifested by duration and intensity of dermatitis, also showed a greater blastogenic response to DNCB-antigen in vitro. This quantitative correlation, however, was not invariant. Certain soluble factor(s), or lymphokines are released following the addition of DNCB-antigen to leukocyte cultures prepared from some sensitive subjects who were rechallenged one or more times with DNCB. These lymphokines induce blastogenesis in secondary target leukocyte populations from nonsensitized subjects. Extended studies are presented which show little or no lymphokine activity in peripheral blood leukocyte cultures during a primary immune response, despite high degrees of blastogenic activity in response to DNCB-antigen. Significant lymphokine activity was observed only following additional rechallenge with DNCB. Blastogenesis and skin reactivity specific for DNCB have been shown to develop at about the same time during a primary immune response. This, along with the quantitative correlation shown in this communication, suggests that both processes probably reflect thymic-dependent cellular immunity. The appearance of lymphokine activity following rechallenge with DNCB suggests that DNCB-induced lymphokines may represent an amplifying mechanism of the cellular immune response that involves recruitment of previously uncommitted lymphocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DINITROCHLOROBENZENE
KW  - ERYTHROCYTES
KW  - LEUCOCYTES
KW  - DNA synthesis
KW  - ANTIGENS
KW  - BLASTOGENESIS (Embryology)
N1  - Accession Number: 12510316; Levis, William R. 1 Whalen, John J. 1 Powell, John A. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Feb75, Vol. 64 Issue 2, p100; Subject Term: DINITROCHLOROBENZENE; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Subject Term: DNA synthesis; Subject Term: ANTIGENS; Subject Term: BLASTOGENESIS (Embryology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12510316
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Khan, A. H.;
AU  - Driscoll, J. S.;
T1  - Active antitumor components in a decomposed amino sugar. 1. Effect of sugar structure on activity
CT  - Active antitumor components in a decomposed amino sugar. 1. Effect of sugar structure on activity
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1975/02/01/
VL  - 64
IS  - Feb
SP  - 295
EP  - 299
SN  - 00223549
AD  - Drug Development Branch, Drug Research and Development, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-0507; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents aminoribose; References: 12; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Pharmacology; Abstract Author: D. R. Tousignaut
N2  - A number of aminoribose derivatives were prepared and tested against the murine L-1210 and P-388 leukemia and the B-16 melanoma tumor systems. Both the \b/-haloethyl group and a secondary amine were required for highest activity.
KW  - Aminoribose--derivatives-;
KW  - Sugars--aminoribose--derivatives, structure-activity relationships, in vitro antitumor effects;
KW  - Antineoplastic agents--aminoribose--derivatives, structure-activity relationships, in vitro effects;
KW  - Structure-activity relationships--aminoribose--derivatives, in vitro antitumor effects;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T.;
AU  - Canellos, G. P.;
AU  - Chabner, B.;
AU  - Schein, P.;
AU  - Hubbard, S. P.;
AU  - \ET/;
T1  - Advanced diffuse histiocytic lymphoma, a potentially curable disease: results with combination chemotherapy
CT  - Advanced diffuse histiocytic lymphoma, a potentially curable disease: results with combination chemotherapy
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1975/02/01/
VL  - 1
IS  - Feb 1
SP  - 248
EP  - 250
SN  - 00237507
AD  - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-3663; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Cyclophosphamide--6055-19-2 Mechlorethamine--51-75-2 Prednisone--53-03-2 Procarbazine--671-16-9 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide, mechlorethamine, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents mechlorethamine, cyclophosphamide, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents prednisone, cyclophosphamide, mechlorethamine, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents procarbazine, cyclophosphamide, mechlorethamine, prednisone and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine, cyclophosphamide, mechlorethamine, prednisone and procarbazine; References: 18; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Twenty-seven patients with advanced diffuse histiocytic lymphoma (reticulum-cell sarcoma) were treated with combination chemotherapy utilizing nitrogen mustard (mechlorethamine) (or cyclophosphamide), procarbazine, vincristine, and prednisone. The MOPP regimen consisted of six 2-week cycles of nitrogen mustard (6 mg/sqm), vincristine (1.4 mg/sqm) on days 1 and 8 of each cycle, procarbazine (100 mg/sqm) per day orally for the first 14 days of each cycle and prednisone (40 mg/sqm) orally on days 1-14 on the first and fourth cycle of treatment. In the C-MOPP variation, cyclophosphamide at a dose of 650 mg/sqm on days 1 and 8 was used interchangeably with nitrogen mustard. Each 14-day cycle was separated by a 2-week rest period. Subsequent cycles were reinstituted on the 28th day from initiation of the previous cycle using a sliding scale for reduction of doses if the white blood cell and platelet counts had not returned entirely to normal. Eleven (41%) achieved a complete remission and only one of these has had a recurrence of tumor. The remaining 10 complete responders were free of all evidence of tumor when last seen 26-105 months from the end of treatment. In contrast, all nonresponders or partial responders have died. An interpretation of published survival data suggests that this virulent disease evolves quickly and is usually rapidly fatal if treatment is unsuccessful. Survival free of disease beyond 2 years from the end of treatment may be considered tantamount to cure. This definition of cure, previously applied only to patients treated with radiotherapy, seems applicable to patients who achieve complete remissions with modern drug treatment.
KW  - Cyclophosphamide--mechlorethamine, prednisone, procarbazine and vincristine-;
KW  - Mechlorethamine--cyclophosphamide, prednisone, procarbazine and vincristine-;
KW  - Prednisone--cyclophosphamide, mechlorethamine, procarbazine and vincristine-;
KW  - Procarbazine--cyclophosphamide, mechlorethamine, prednisone and vincristine-;
KW  - Vincristine--cyclophosphamide, mechlorethamine, prednisone and procarbazine-;
KW  - Antineoplastic agents--cyclophosphamide, mechlorethamine, prednisone, procarbazine and vincristine--lymphomas, histiocytic, in patients;
KW  - Antineoplastic agents--mechlorethamine, cyclophosphamide, prednisone, procarbazine and vincristine--lymphomas, histiocytic, in patients;
KW  - Antineoplastic agents--prednisone, cyclophosphamide, mechlorethamine, procarbazine and vincristine--lymphomas, histiocytic, in patients;
KW  - Antineoplastic agents--procarbazine, cyclophosphamide, mechlorethamine, prednisone and vincristine--lymphomas, histiocytic, in patients;
KW  - Antineoplastic agents--vincristine, cyclophosphamide, mechlorethamine, prednisone and procarbazine--lymphomas, histiocytic, in patients;
KW  - Combined therapy--antineoplastic agents--lymphomas, histiocytic, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Weiss, George H.
T1  - Letter to the Editor.
JO  - Transportation Science
JF  - Transportation Science
Y1  - 1975/02//
VL  - 9
IS  - 1
M3  - Letter
SP  - 86
PB  - INFORMS: Institute for Operations Research
SN  - 00411655
AB  - Presents a letter to the editor regarding solution to an integral equation in the study of semi-poisson headway distribution.
KW  - INTEGRAL equations
KW  - LETTERS to the editor
KW  - POISSON distribution
N1  - Accession Number: 5848322; Weiss, George H. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland; Source Info: Feb75, Vol. 9 Issue 1, p86; Subject Term: INTEGRAL equations; Subject Term: LETTERS to the editor; Subject Term: POISSON distribution; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - PIEZ, KARL A.
T1  - NIH Management.
JO  - Science
JF  - Science
Y1  - 1975/02/14/
VL  - 187
IS  - 4176
M3  - Article
SP  - 497
EP  - 497
SN  - 00368075
N1  - Accession Number: 85118503; PIEZ, KARL A. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/14/1975, Vol. 187 Issue 4176, p497; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jacobs, S. A.;
AU  - Bleyer, W. A.;
AU  - Chabner, B. A.;
AU  - Johnson, D. G.;
T1  - Altered plasma pharmacokinetics of methotrexate administered intrathecally
CT  - Altered plasma pharmacokinetics of methotrexate administered intrathecally
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1975/02/22/
VL  - 1
IS  - Feb 22
SP  - 465
EP  - 466
SN  - 00237507
AD  - Laboratory of Chemical Pharmacology and Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-3664; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 6; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2  - A pilot pharmacokinetic study in 2 patients with lymphocytic leukemia showed that methotrexate, when administered intrathecally acts as a depot or slow release form of the drug. Plasma concentrations remain at a pharmacologically significant level more than twice as long after an intrathecal dose as after an oral or IV dose.
KW  - Methotrexate--pharmacokinetics-;
KW  - Pharmacokinetics--methotrexate--sustained-action, following intrathecal administration, in patients;
KW  - Antineoplastic agents--methotrexate--pharmacokinetics, sustained-action, following intrathecal administration, in patients;
KW  - Sustained-action medications--methotrexate--pharmacokinetics, following intrathecal administration, in patients;
KW  - Drug administration--routes--methotrexate, sustained-action, following intrathecal administration, in patients;
KW  - Blood levels--methotrexate--sustained-action, following intrathecal administration, in patients;
KW  - Metabolism--methotrexate--sustained-action, following intrathecal administration, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - DVORAK, JAMES A.
AU  - MILLER, LOUIS H.
AU  - WHITEHOUSE, WILLARD C.
AU  - SHIROISHI, TSUGIYE
T1  - Invasion of Erythrocytes by Malaria Merozoites.
JO  - Science
JF  - Science
Y1  - 1975/02/28/
VL  - 187
IS  - 4178
M3  - Article
SP  - 748
EP  - 750
SN  - 00368075
AB  - An electro-optical system was developed to record microscope images with high resolution at low light intensities. The system was used to study the invasion of erythrocytes by malaria merozoites. Invasion consists of attachment of the anterior end of the parasite to the erythrocyte, deformation of the erythrocyte, and entry of the parasite by erythrocyte membrane invagination. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118603; DVORAK, JAMES A. 1,2; MILLER, LOUIS H. 1,2; WHITEHOUSE, WILLARD C. 3; SHIROISHI, TSUGIYE 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases; 2: National Institutes of Health, Bethesda, Maryland 20014; 3: Television Engineering Section, Clinical Center, National Institutes of Health; Issue Info: 2/28/1975, Vol. 187 Issue 4178, p748; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Post, R. M.;
T1  - Cocaine psychoses: a continuum model
CT  - Cocaine psychoses: a continuum model
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1975/03/01/
VL  - 132
IS  - Mar
SP  - 225
EP  - 231
SN  - 0002953X
AD  - 3-West Clinical Research Unit, Section of Psychobiology, Adult Psychiatric Branch, Building 10, Room 3S239, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 12-6539; Language: English; Chemical Name: Cocaine--50-36-2; References: 67; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: C. Robert Sturwold
N2  - Clinical aspects of cocaine euphoria, disphoria, and paranoid psychosis are reviewed. Increasing the dose and/or the chronicity of cocaine administration is associated with increasingly severe affective and cognitive alterations. Personality and experimental-genetic predispositions are crucial factors in determining the patient's response to cocaine. Pre-existing active psychopathologies including schizophrenia, mania, and depression are shown to alter the proposed progression of cocaine-induced symptomatology. The cocaine syndromes mirror many aspects of the endogenous psychoses closely enough to warrant comparison, the model derived from such study may be useful in conceptualizing biochemical-behavioral interactions.
KW  - Cocaine--toxicity-;
KW  - Toxicity--cocaine--behavioral, review, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Zahn, T. P.;
AU  - Abate, F.;
AU  - Little, B. C.;
AU  - Wender, P. H.;
T1  - Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity
CT  - Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1975/03/01/
VL  - 32
IS  - Mar
SP  - 381
EP  - 387
AD  - National Institutes of Health, Bldg 10, Rm 2N-262, Bethesda, Maryland 20014
AD  - Unit on Psychophysiology, National Institute of Mental Health, Public Health Service, Dept. of H. E. W. Bethesda, Maryland
N1  - Accession Number: 13-1114; Language: English; Trade Name: Ritalin; Generic Name: Methylphenidate; Chemical Name: Methylphenidate--113-45-1 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants methylphenidate (28:20); AHFS Class: Central nervous system stimulants dextroamphetamine; References: 26; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - Minimally brain dysfunctioned children on methylphenidate HC1 (Ritalin) or dextroamphetamine sulfate had increased skin conductance and heart rate and decreased skin temperatiure and reaction time when compared to baseline values obtained from normal and minimally brain dysfunctioned children not taking drugs. In the study of 54 normal and 42 minimally brain dysfunctioned children, autonomic base levels and responsivity to stimuli were investigated. The minimally brain dysfunctioned children were less reactive, autonomically, to all types of stimuli.
KW  - Methylphenidate--effects-;
KW  - Dextroamphetamine--effects-;
KW  - Hyperkinesis--methylphenidate--effects, autonomic, in children;
KW  - Hyperkinesis--dextroamphetamine--effects, autonomic, in children;
KW  - Central nervous system stimulants--methylphenidate--effects, autonomic, in minimal brain dysfunction children;
KW  - Central nervous system stimulants--dextroamphetamine--effects, autonomic, in minimal brain dysfunction children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Watanabe, H.;
AU  - Passonneau, J. V.;
T1  - Cyclic adenosine monophosphate in cerebral cortex
CT  - Cyclic adenosine monophosphate in cerebral cortex
JO  - Arch. Neurol. (Chicago)
JF  - Arch. Neurol. (Chicago)
Y1  - 1975/03/01/
VL  - 32
IS  - Mar
SP  - 181
EP  - 184
AD  - Dept. of Neurosurgery, Juntendo Univ., Tokyo, Japan
AD  - Reprints: Section on Cellular Neurochemistry, Laboratory of Neuropathology and Neurochemistry Sciences, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bldg. 36, Rm. 4D-16, Bethesda, Maryland 20014
N1  - Accession Number: 13-0775; Language: English; Chemical Name: Theophylline--5967-84-0 Chlorpromazine--50-53-3 Trifluoperazine--117-89-5 Diphenhydramine--58-73-1 Reserpine--50-55-5; Therapeutic Class: (12:08.08); AHFS Class: Spasmolytics theophylline (28:16.08); AHFS Class: Tranquilizers chlorpromazine (28:16.08); AHFS Class: Tranquilizers trifluoperazine (4:00); AHFS Class: Antihistamines diphenhydramine (24:08); AHFS Class: Hypotensive agents dichloroisoproterenol (12:16); AHFS Class: Sympatholytic agents pronethalol (24:08); AHFS Class: Hypotensive agents reserpine; References: 32; Journal Coden: ARNEAS; Section Heading: Pharmacology
N2  - Stab-wound injury produced a 7-fold elevation in cyclic adenosine monophosphate (AMP) in mouse brain within one minute; the increase in cyclic AMP in the brain was blocked by prior treatment of the animal by theophylline, chlorpromazine, trifluoperazine HCl, and diphenhydramine HCl. Neither dichloroisoproterenol, pronethalol, nor reserpine blocked the rise in cyclic AMP concentration due to injury. The results following administration of drugs suggest that the increases in cyclic AMP due to injury may be mediated by adenosine. Theophylline and phenothiazine derivatives have been shown previously to decrease adenosine-mediated increases in cyclic AMP in brain slices. The absence of any effect after administration of dichloroisoproterenol or pronethalol suggests that the increase in cyclic AMP after injury is not through catecholamine release. Hypothermia reduced the increase in cyclic AMP in injured brain after one minute.
KW  - Theophylline--effects-;
KW  - Chlorpromazine--effects-;
KW  - Trifluoperazine--effects-;
KW  - Diphenhydramine--effects-;
KW  - Dichloroisoproterenol--effects-;
KW  - Pronethalol--effects-;
KW  - Reserpine--effects-;
KW  - Spasmolytics--theophylline--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW  - Tranquilizers--chlorpromazine--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW  - Tranquilizers--trifluoperazine--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW  - Antihistamines--diphenhydramine--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW  - Hypotensive agents--dichloroisoproterenol--lack, effects, on rise in cyclic AMP due to injury, in mouse brain;
KW  - Sympatholytic agents--pronethalol--lack, effects, on rise in cyclic AMP due to injury, in mouse brain;
KW  - Hypotensive agents--reserpine--lack, effects, on rise in cyclic AMP due to injury, in mouse brain;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Albright, L.;
AU  - Madigan, J.;
AU  - Gaston, M.;
AU  - Houchens, D.;
T1  - Therapy in an intracerebral murine glioma model, using bacillus calmette-guerin, neuraminidase-treated tumor cells, and 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea
CT  - Therapy in an intracerebral murine glioma model, using bacillus calmette-guerin, neuraminidase-treated tumor cells, and 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/03/01/
VL  - 35
IS  - Mar
SP  - 658
EP  - 665
SN  - 00085472
AD  - National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 12-6596; Language: English; Trade Name: 1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosourea; Generic Name: Lomustine; Chemical Name: Lomustine--13010-47-4; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines (10:00); AHFS Class: Antineoplastic agents lomustine; References: 27; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology
N2  - In vivo therapy studies revealed significant increased survival of animals injected with GL-26 murine glioma who were preimmunized with V. cholerae neuraminidase and mitomycin C-treated cells plus complete Freund's adjuvant. 1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosourea (lomustine: I), when given IP on day 3 or 12 after tumor challenge, also resulted in significant increases in survival. Furthermore, the effects of I and preimmunization were additive, with significant additional protection occurring in animals that had received preimmunization as well as I. In contrast to results reported for several extracranial tumor systems, immunotherapy, using either V. cholerae neuraminidase and mitomycin-treated tumor cells, Bacillus Calmette-Guerin, or both beginning 3 or 4 days after tumor challenge, did not produce any significant increases in survival.
KW  - BCG vaccines--effects-;
KW  - Lomustine--effects-;
KW  - Immunosuppressive agents--BCG vaccines--effects, survival, in animals treated with GL-26 murine glioma;
KW  - Antineoplastic agents--lomustine--effects, survival, in animals treated with GL-26 murine glioma;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Anderson, T.;
AU  - McMenamin, M. G.;
AU  - Schein, P. S.;
T1  - Chlorozotocin, 2-[3-(2-chloroethyl)-3-nitrosoureido]-d-glucopyranose, an antitumor agent with modified bone marrow toxicity
CT  - Chlorozotocin, 2-[3-(2-chloroethyl)-3-nitrosoureido]-d-glucopyranose, an antitumor agent with modified bone marrow toxicity
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/03/01/
VL  - 35
IS  - Mar
SP  - 761
EP  - 765
SN  - 00085472
AD  - Clinical Pharmacology Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-5911; Language: English; Trade Name: 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose; Generic Name: Chlorozotocin; Chemical Name: Chlorozotocin--54749-90-5; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents chlorozotocin; References: 9; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing
N2  - A 701% and a 401% increase in life-span were attained with chlorozotocin, 15-20 mg/kg IP, in mice treated on day 2 or day 6 of L1210 leukemia tumor growth, respectively. Sixty percent of day 2-treated mice and 30% of day 6-treated mice survived for 90 days. At the maximally effective dose against L1210, chlorozotocin produced no significant depression in normal bone marrow DNA synthesis nor in peripheral neutrophil count, in contrast to a sustained \GT/ 90% inhibition in L1210 ascites cell DNA synthesis. If the antitumor activity and reduced bone marrow toxicity of chlorozotocin are confirmed in man, the use of this compound would facilitate treatment of patients with neoplastic disease who have preexisting abnormal bone marrow function or would allow for the more effective use of a nitrosourea agent in combination with anticancer agents possessing more potent myelosuppressive properties.
KW  - Chlorozotocin--leukemias-;
KW  - Antineoplastic agents--chlorozotocin--leukemias, therapy, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Waldrop, Mary F.
AU  - Halverson Jr., Charles F.
T1  - Intensive and Extensive Peer Behavior: Longitudinal and Cross-sectional Analyses.
JO  - Child Development
JF  - Child Development
Y1  - 1975/03//
VL  - 46
IS  - 1
M3  - Article
SP  - 19
EP  - 26
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12189684; Waldrop, Mary F. 1 Halverson Jr., Charles F. 1; Affiliation:  1: Child Research Branch, National Institute of Mental Health; Source Info: Mar1975, Vol. 46 Issue 1, p19; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1467-8624.ep12189684
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Campbell, John D.
T1  - Illness Is a Point of View: The Development of Children's Concepts of Illness.
JO  - Child Development
JF  - Child Development
Y1  - 1975/03//
VL  - 46
IS  - 1
M3  - Article
SP  - 92
EP  - 100
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12189728; Campbell, John D. 1; Affiliation:  1: National Institute of Mental Health; Source Info: Mar1975, Vol. 46 Issue 1, p92; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1467-8624.ep12189728
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jasinski, D. R.;
AU  - Griffith, J. D.;
AU  - Carr, C. B.;
T1  - Etorphine in man. 1. Subjective effects and suppression of morphine abstinence
CT  - Etorphine in man. 1. Subjective effects and suppression of morphine abstinence
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1975/03/01/
VL  - 17
IS  - Mar
SP  - 267
EP  - 272
SN  - 00099236
AD  - National Institute on Drug Abuse, Addiction Research Center, Lexington, Kentucky
N1  - Accession Number: 12-6401; Language: English; Chemical Name: Etorphine--14521-96-1 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, etorphine (28:08); AHFS Class: Analgesics and antipyretics etorphine, comparison, morphine; References: 10; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2  - The effects of etorphine (I) were qualitatively and quantitatively compared to those of morphine. In 12 nondependent subjects, I in doses of 0.025, 0.050, and 0.100 mg produced pupillary constriction and morphine-like subjective effects and euphoria. I was 500 times as potent as morphine, with a very rapid onset and short duration of action. In 4 morphine-dependent subjects, I suppressed abstinence but for a shorter period than morphine. These studies indicate than in man I is a morphine-like drug with a high abuse potential.
KW  - Etorphine--comparison, morphine-;
KW  - Morphine--comparison, etorphine-;
KW  - Dependence--etorphine, comparison, morphine--effects, dosage, in patients;
KW  - Dosage--etorphine, comparison, morphine--effects, in patients;
KW  - Dependence--morphine, comparison, etorphine--effects, dosage, in patients;
KW  - Dosage--morphine, comparison, etorphine--effects, and dependence, in patients;
KW  - Analgesics and antipyretics--morphine, comparison, etorphine--dosage, and dependent effects, in patients;
KW  - Analgesics and antipyretics--etorphine, comparison, morphine--dosage, and dependent effects, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gorodetzky, C. W.;
AU  - Kullberg, M. P.;
T1  - Etorphine in man. 2. Detectability in urine by common screening methods
CT  - Etorphine in man. 2. Detectability in urine by common screening methods
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1975/03/01/
VL  - 17
IS  - Mar
SP  - 273
EP  - 276
SN  - 00099236
AD  - National Institute on Drug Abuse, Addiction Research Center, and Univ. of Kentucky College of Medicine, Dept. of Psychiatry, Lexington, Kentucky
N1  - Accession Number: 12-5782; Language: English; Chemical Name: Etorphine--14521-96-1; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics etorphine; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Drug Analysis
N2  - A single highly euphorogenic dose of etorphine (I), 100 mcg, was administered SC to 7 nontolerant subjects, and all urine samples were collected for one day prior to and 3 days following drug administration. Samples were analyzed for the presence of opiates by radioimmunoassay (Abuscreen) and homogeneous enzyme immunoassay (EMIT), with cutoffs for positives of 40 and 500 mg/ml, respectively. Samples were analyzed for I by thin layer chromatography (TLC) with iodoplatinate preceded by XAD-2 resin extraction (sensitivity = 0.2 mcg/ml of urine) and by gas-liquid chromatography (GLC) preceded by organic solvent extraction and trimethylsilyl derivatization (sensitivity = 0.1 mcg I/ml of urine). The last pre-drug and first two post-drug samples were also analyzed after acid hydrolysis by TLC and after glucuronidase hydrolysis by TLC and GLC. No sample gave a positive opiate result in either immunoassay, and no I was detected in the TLC and GLC analyses of any urine sample. Thus, it is unlikely that the abuse of I could be diagnosed by urinalysis using the common screening methods of radioimmunoassay, EMIT, TLC preceded by XAD-2 resin extraction, or GLC preceded by organic solvent extraction and trimethylsilyl derivatization.
KW  - Etorphine--excretion-;
KW  - Excretion--etorphine--urinary, lack, GLC and TLC detection, in humans;
KW  - Metabolism--etorphine--excretion, urinary, lack, GLC and TLC detection, in humans;
KW  - Dependence--etorphine--excretion, urinary, lack, GLC and TLC detection, in humans;
KW  - Chromatography, thin layer--etorphine--urine, detection, lack, in humans;
KW  - Chromatography, gas--etorphine--urine, detection, lack, in humans;
KW  - Analgesics and antipyretics--morphine--excretion, detection in urine, lack, GLC and TLC;
KW  - Analgesics and antipyretics--etorphine--excretion, detection in urine, lack, GLC and TLC;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Andres, Reubin
T1  - Defining and evaluating the myriad influences on human aging.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1975/03//
VL  - 30
IS  - 3
M3  - Article
SP  - 36
EP  - 40
SN  - 0016867X
N1  - Accession Number: 18945341; Andres, Reubin 1; Source Information: Mar1975, Vol. 30 Issue 3, p36; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1435
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Balow, J.;
AU  - Hurley, D. L.;
AU  - Fauci, A. S.;
T1  - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
CT  - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
JO  - J. Immunol.
JF  - J. Immunol.
Y1  - 1975/03/01/
VL  - 114
IS  - Mar
SP  - 1072
EP  - 1076
AD  - National Institute of Allergy and Infectious Diseases, N1H, Bethesda, Maryland 20014
N1  - Accession Number: 12-6541; Language: English; Chemical Name: Hydrocortisone--50-23-7 Cortisone--53-06-5; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- hydrocortisone (68:04); AHFS Class: Steroids, cortico- cortisone; References: 17; Journal Coden: JOIMA3; Section Heading: Pharmacology
N2  - The effects of acute vs chronic glucocorticosteroid administration on established cellular immune responses were studied in guinea pigs previously sensitized to tuberculin. A greater than 50% reduction in circulating lymphocytes was observed 4 hr after injection of soluble hydrocortisone (I) and 24 hr after daily SC injections of depot cortisone acetate (II). After a single dose of I, peripheral lymphocyte migration inhibitory factor production and antigen and mitogen-induced proliferation were unchanged. However, the peripheral lymphocytes remaining in the circulation after chronic II treatment showed a marked decrease in both antigen-induced migration inhibitory factor and proliferation, although mitogen responses remained normal. Although similar levels of lymphocytopenia were induced by acute and chronic glucocorticosteroid administration, only chronic treatment was associated with depression of certain cell-mediated lymphocyte functions. The available evidence suggests that these changes may depend on glucocorticosteroid-induced selective alterations in the circulation patterns of certain subpopulations of lymphocytes.
KW  - Hydrocortisone--dosage schedules-;
KW  - Cortisone--dosage schedules-;
KW  - Dosage schedules--cortisone--chronic, comparison, acute, effects on cellular immune response, in guinea pigs;
KW  - Dosage schedules--hydrocortisone--chronic, comparison, acute, effects on cellular immune response, in guinea pigs;
KW  - Steroids, cortico---hydrocortisone--dosage schedules, chronic and acute, effects on cellular immune response, in guinea pigs;
KW  - Steroids, cortico---cortisone--dosage schedules, chronic and acute, effects on cellular immune response, in guinea pigs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Barlow, J. E.;
AU  - Hurley, D. L.;
AU  - Fauci, A. S.;
T1  - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
CT  - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
JO  - J. Immunol.
JF  - J. Immunol.
Y1  - 1975/03/01/
VL  - 114
IS  - Mar
SP  - 1072
EP  - 1076
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 13-0144; Language: English; Chemical Name: Hydrocortisone--50-23-7 Cortisone--53-06-5; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- hydrocortisone (68:04); AHFS Class: Steroids, cortico- cortisone; References: 17; Journal Coden: JOIMA3; Section Heading: Pharmacology
N2  - The effects of acute and chronic glucocorticosteroid administration on established cellular immune responses were compared in guinea pigs previously sensitized to tuberculin. A greater than 50% reduction in circulating lymphocytes was observed 4 hr after injection of soluble hydrocortisone and 24 hr after daily SC injections of depot cortisone acetate. After a single dose of hydrocortisone, peripheral lymphocyte migration inhibitory factor production and antigen and mitogen-induced proliferation were unchanged. However, the peripheral lymphocytes remaining in the circulation after chronic cortisone treatment showed a marked decrease in both antigen-induced migration inhibitory factor and proliferation, although mitogen responses remained normal. Although similar levels of lymphocytopenia were induced by acute and chronic treatment, only chronic treatment was associated with depression of certain cell-mediated lymphocyte functions. The available evidence suggests that these changes may depend on glucocorticosteroid-induced selective alterations in the circulation patterns of certain subpopulations of lymphocytes.
KW  - Hydrocortisone--effects-;
KW  - Cortisone--effects-;
KW  - Steroids, cortico---hydrocortisone--effects, immune response, in tuberculin sensitive guinea pigs;
KW  - Steroids, cortico---cortisone--effects, on immune response, in tuberculin sensitive guinea pigs;
KW  - Immunology--cortisone--effects, in tuberculin sensitive guinea pigs;
KW  - Immunology--hydrocortisone--effects, in tuberculin sensitive guinea pigs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Robbins, Jay H.
AU  - Kraemer, Kenneth H.
AU  - Flaxman, B. Allen
T1  - DNA REPAIR IN TUMOR CELLS FROM THE VARIANT FORM OF XERODERMA PIGMENTOSUM.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/03//
VL  - 64
IS  - 3
M3  - Article
SP  - 150
EP  - 155
SN  - 0022202X
AB  - Cells from most patients with xeroderma pigmentosum (XP) can be shown to be defective in repairing ultraviolet (UV) light-induced damage to their DNA, for they have a reduced rate of UV-induced thymidine incorporation. XP variants, however, have clinical manifestations of XP, but all their tissues tested to date have a normal rate of UV-induced 3H-thymidine incorporation. We have now tested tumor cells from an XP variant and from a typical XP patient. The variant's tumor cells, in contrast to those of the typical patient, had no detectable defect in their UV-induced thymidine incorporation. We conclude, therefore, that the cells that formed tumors in this XP variant resemble his other cells in DNA repair capacity, and do not represent a minor cell population with the kind of DNA repair defect that is reflected in reduced UV-induced thymidine incorporation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA repair
KW  - XERODERMA pigmentosum
KW  - PRECANCEROUS conditions
KW  - CANCER cells
KW  - ULTRAVIOLET radiation
KW  - THYMIDINE
N1  - Accession Number: 12533310; Robbins, Jay H. 1,2 Kraemer, Kenneth H. 1,2 Flaxman, B. Allen 1,2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: Skin and Cancer Hospital of Philadelphia, Department of Dermatology, Temple University Health Sciences Center, Philadelphia, Pennsylvania.; Source Info: Mar1975, Vol. 64 Issue 3, p150; Subject Term: DNA repair; Subject Term: XERODERMA pigmentosum; Subject Term: PRECANCEROUS conditions; Subject Term: CANCER cells; Subject Term: ULTRAVIOLET radiation; Subject Term: THYMIDINE; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12533310
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wiebel, F. J.
AU  - Leutz, J. C.
AU  - Gelboin, H. V.
T1  - ARYL HYDROCARBON (BENZO[A]PYRENE) HYDROXYLASE: A MIXED-FUNCTION OXYGENASE IN MOUSE SKIN.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/03//
VL  - 64
IS  - 3
M3  - Article
SP  - 184
EP  - 189
SN  - 0022202X
AB  - Mouse skin contains awl hydrocarbon (benzo[a]pyrene) hydroxylase activity which is inducible by aromatic polycyclic hydrocarbons and benzoflavones. The duration and magnitude of induction, but not the initial kinetics, are dependent on the inducer dose. The cutaneous hydroxylase activity is inhibited by carbon monoxide and requires the presence of NADPH, indicating that the enzyme is one of the mixed-function oxygenases. The highest enzyme activity was found in the superficial layer of skin which contains the sebaceous glands and the upper pilary canals. Enzyme activities were intermediate in the epidermis and lowest in the deeper dermal layers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYDROCARBONS
KW  - EPITHELIUM
KW  - SKIN
KW  - CARBON monoxide
KW  - OXYGENASES
KW  - ENZYMES
KW  - ENZYME kinetics
N1  - Accession Number: 12533351; Wiebel, F. J. 1 Leutz, J. C. 1 Gelboin, H. V. 1; Affiliation:  1: Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Mar1975, Vol. 64 Issue 3, p184; Subject Term: HYDROCARBONS; Subject Term: EPITHELIUM; Subject Term: SKIN; Subject Term: CARBON monoxide; Subject Term: OXYGENASES; Subject Term: ENZYMES; Subject Term: ENZYME kinetics; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12533351
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Linsky, Arnold S.
T1  - STIMULATING RESPONSES TO MAILED QUESTIONNAIRES: A REVIEW.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1975///Spring75
VL  - 39
IS  - 1
M3  - Article
SP  - 82
PB  - Oxford University Press / USA
SN  - 0033362X
AB  - This study collates findings from the available research literature of sociology, psychology, business, and education on techniques to increase responses to mailed questionnaires. Among the techniques reviewed here are those that employ mechanical or perceptual means to facilitate responses, those that use broad motivational factors to build on social and personal values of the respondent, and those that offer direct rewards for return of questionnaires. It is concluded that a change in over-all research strategy may be necessary to increase our ability to ensure high mail-questionnaire returns. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Questionnaires
KW  - Sociology
KW  - Psychology
KW  - Business
KW  - Education
KW  - Mail surveys
N1  - Accession Number: 5412934; Linsky, Arnold S. 1,2; Affiliations: 1: Associate Professor, Department of Sociology and Anthropology, University of New Hampshire.; 2: Research Director for the National Institute of Mental Health Training Project, "Family, Community Agencies, and Behavior Problems," University of New Hampshire.; Issue Info: Spring75, Vol. 39 Issue 1, p82; Thesaurus Term: Questionnaires; Thesaurus Term: Sociology; Thesaurus Term: Psychology; Thesaurus Term: Business; Thesaurus Term: Education; Subject Term: Mail surveys; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 20p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - GEN
AU  - Weissman, Harold
AU  - Smith, Neilson F.
AU  - Pappenfort, Donnell M.
AU  - Taylor, Delores A.
AU  - Causemaker, Carole J.
AU  - Chapla, Lee S.
AU  - Dalrymple, Irene Grant
T1  - letters.
JO  - Social Work
JF  - Social Work
Y1  - 1975/03//
VL  - 20
IS  - 2
M3  - Letter
SP  - 171
EP  - 172
PB  - Oxford University Press / USA
SN  - 00378046
AB  - Presents several letters to the editor. Response of a reader on comments made by scholar Donald Vorwaller on the book "Overcoming Mismanagement in the Human Service Professions "; Feedback of a reader on a collection of commissioned papers "Child Caring: Social Policy and the institution"; Comments of a reader on the article "A Study of Homosexual Women."
KW  - LETTERS to the editor
KW  - PUBLIC welfare
KW  - HUMAN services
KW  - SOCIAL marketing
KW  - WELFARE economics
KW  - SOCIAL policy
N1  - Accession Number: 5267416; Weissman, Harold 1 Smith, Neilson F. 2 Pappenfort, Donnell M. 3 Taylor, Delores A. 4 Causemaker, Carole J. Chapla, Lee S. 5 Dalrymple, Irene Grant; Affiliation:  1: Hunter College School of Social Work, New York, New York.  2: Division of Manpower and Training Programs, National Institute of Mental Health, Rockville, Maryland.  3: School of Social Service Administration, University of Chicago, Chicago, Illinois.  4: Child and Family Services of Connecticut, Hartford, Connecticut.  5: Norristown State Hospital, Norristown, Pennsylvania.; Source Info: Mar75, Vol. 20 Issue 2, p171; Subject Term: LETTERS to the editor; Subject Term: PUBLIC welfare; Subject Term: HUMAN services; Subject Term: SOCIAL marketing; Subject Term: WELFARE economics; Subject Term: SOCIAL policy; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - STONE, T. W.
AU  - TAYLOR, D. A.
AU  - BLOOM, F. F.
T1  - Cyclic AMP and Cyclic GMP May Mediate Opposite Neuronal Responses in the Rat Cerebral Cortex.
JO  - Science
JF  - Science
Y1  - 1975/03/07/
VL  - 187
IS  - 4179
M3  - Article
SP  - 845
EP  - 847
SN  - 00368075
AB  - Electrophysiologically identified pyramidal tract neurons in the rat cerebral cortex were tested with norepinephrine, acetylcholine, adenosine 3',5'- monophosphate (cyclic AMP), and guanosine 3',5'-monophosphate (cyclic GMP) applied by microiontophoresis. The neurons were usually inhibited by norepinephrine and cyclic AMP, but excited by acetylcholine and cyclic GMP. These opposing responses of pyramidal tract neurons to cyclic AMP and cyclic GMP suggests that these two nucleotides could function as reciprocal intracellular second messengers for norepinephrine and acetylcholine, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118646; STONE, T. W. 1; TAYLOR, D. A. 1; BLOOM, F. F. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 7/1975, Vol. 187 Issue 4179, p845; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KENNEDY, C.
AU  - ROSIERS, M. H. DES
AU  - JEHLE, J. W.
AU  - REIVICH, M.
AU  - SHARPE, F.
AU  - SOKOLOFF, L.
T1  - Mapping of Functional Neural Pathways by Autoradiographic Survey of Local Metabolic Rate with [14C]Deoxyglucose.
JO  - Science
JF  - Science
Y1  - 1975/03/07/
VL  - 187
IS  - 4179
M3  - Article
SP  - 850
EP  - 853
SN  - 00368075
AB  - If sufficient time has elapsed following an intravenous pulse of [14C]deoxyglucose, the carbon-14 contents of the tissues of the central nervous system represent mainly the accumulated phosphorylated derivative of [14C]deoxyglucose and reflect the rates of glucose consumption of the tissues. Altered functional activity alters metabolic activity and the uptake of [14C]deoxyglucose in the tissues. By autoradiographic survey of sections of the central nervous system it is then possible to map all the regions with altered functional and metabolic activities in response to experimentally induced changes in functional state. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118649; KENNEDY, C. 1; ROSIERS, M. H. DES 1; JEHLE, J. W. 1; REIVICH, M. 2; SHARPE, F. 3; SOKOLOFF, L. 4; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Neurology, University of Pennsylvania, Philadelphia 19174; 3: Laboratory of Neurophysiology, National Institute of Mental Health; 4: Laboratory of Cerebral Metabolism, National Institute of Mental Health; Issue Info: 3/ 7/1975, Vol. 187 Issue 4179, p850; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SHERR, CHARLES J.
AU  - TODARO, GEORGE J.
T1  - Primate Type C Virus p3O Antigen in Cells from Humans with Acute Leukemia.
JO  - Science
JF  - Science
Y1  - 1975/03/07/
VL  - 187
IS  - 4179
M3  - Article
SP  - 855
EP  - 857
SN  - 00368075
AB  - Antigens related to the major structural protein (p30) of type C viruses isolated from a woolly monkey and a gibbon ape were found in peripheral white blood cells from five patients with acute leukemia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118651; SHERR, CHARLES J. 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/ 7/1975, Vol. 187 Issue 4179, p855; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Karlowski, T. R.;
AU  - Chalmers, T. C.;
AU  - Frenkel, L. D.;
AU  - Kapikian, A. Z.;
AU  - Lewis, T. L.;
AU  - \ET/;
T1  - Ascorbic acid for the common cold: prophylactic and therapeutic trial
CT  - Ascorbic acid for the common cold: prophylactic and therapeutic trial
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1975/03/10/
VL  - 231
IS  - Mar 10
SP  - 1038
EP  - 1042
AD  - Reprints: Mount Sinai Medical Center, Fifth Ave. and 100th St., New York, New York 10029
AD  - National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-4634; Language: English; Chemical Name: Ascorbic acid--50-81-7; References: 12; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - A long-term prospective double-blind trial with high doses of ascorbic acid was designed to measure as well as distinguish between the prophylactic and therapeutic effects of the drug in treating the common cold. One g of ascorbic acid or lactose placebo in capsules was taken 3 times a day for 9 months by 311 volunteers. At the onset of a cold, patients were given an additional 3 g daily of either a placebo or ascorbic acid. One hundred ninety volunteers completed the study. Dropouts were defined as those who missed at least one month of drug ingestion. They represented 44% of the placebo group and 34% of those taking ascorbic acid. Analysis of these data showed that ascorbic acid had at best only a minor influence on the duration and severity of colds, and that the effects demonstrated might be explained equally well by a break in the double-blind.
KW  - Ascorbic acid--colds-;
KW  - Dosage--ascorbic acid--high, colds, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - SATTIN, ALBERT
AU  - AXELROD, JULIUS
AU  - KOPIN, IRWIN J.
AU  - NAUTA, WALLE J. H.
T1  - Ilya Glezer's Struggle.
JO  - Science
JF  - Science
Y1  - 1975/03/14/
VL  - 187
IS  - 4180
M3  - Article
SP  - 907
EP  - 907
SN  - 00368075
N1  - Accession Number: 85118656; SATTIN, ALBERT 1; AXELROD, JULIUS 2; KOPIN, IRWIN J. 2; NAUTA, WALLE J. H. 3; Affiliations: 1: Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106; 2: National Institute of Mental Health, Bethesda, Maryland 20014; 3: Department of Psychology, Massachusetts Institute of Technology, Cambridge 02139; Issue Info: 3/14/1975, Vol. 187 Issue 4180, preceding p907; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PRICE, PAUL J.
AU  - SUK, WILLIAM A.
AU  - SKEEN, PAMELA C.
AU  - CHIRIGOS, MICHAEL A.
AU  - HUEBNER, ROBERT J.
T1  - Transforming Potential of the Anticancer Drug Adriamycin.
JO  - Science
JF  - Science
Y1  - 1975/03/28/
VL  - 187
IS  - 4182
M3  - Article
SP  - 1200
EP  - 1201
SN  - 00368075
AB  - A Fischer rat embryo cell system in vitro, which had been shown to be highly accurate in identifying chemical carcinogens and to have application in the study of chemicals having anticancer properties, was used to study the anticancer drug adriamycin. At a nontoxic dose adriamycin not only did not protect the cells from transformation by the carcinogen 3-methylcholanthrene, but was found in two separate experiments to act on its own as a transforming agent. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118759; PRICE, PAUL J. 1; SUK, WILLIAM A. 1; SKEEN, PAMELA C. 1; CHIRIGOS, MICHAEL A. 2; HUEBNER, ROBERT J. 2; Affiliations: 1: Microbiological Associates, Bethesda, Maryland 20014; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/28/1975, Vol. 187 Issue 4182, p1200; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gochman, N.;
AU  - Young, D. S.;
T1  - Clinical chemistry
CT  - Clinical chemistry
JO  - Anal. Chem.
JF  - Anal. Chem.
Y1  - 1975/04/01/
VL  - 47
IS  - Apr
SP  - 16R
EP  - 37R
AD  - VA Hospital, San Diego, California 92161 and National Institutes of Health Bethesda, Maryland 20014
N1  - Accession Number: 12-4437; Language: English; References: 771; Journal Coden: ANCHAM; Section Heading: Pharmaceutical Chemistry; Drug Analysis; Abstract Author: Douglas L. Thompson
N2  - This selective review of clinical chemistry covers the period from December 1972 to November 1974. The primary emphasis is on the development and evaluation of the analytical methodology of clinical chemistry, with only limited references to the extensive role of this specialty in clinical diagnosis, patient therapy, and biomedical research. Topics discussed include toxicology, drugs and vitamins, screening and profile techniques, and hormone analysis.
KW  - Chemistry--clinical--review;
KW  - Hormones--analysis--review, clinical chemistry;
KW  - Drugs--analysis--review, clinical chemistry;
KW  - Analysis--hormones--and drugs, clinical chemistry, review;
KW  - Vitamins--analysis--review, clinical chemistry;
KW  - Toxicity--chemistry--clinical, role;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chirigos, M. A.;
AU  - Fuhrman, F. S.;
AU  - Pryor, J. W.;
T1  - Prolongation of chemotherapeutically induced remission of a syngeneic murine leukemia by L-2,3,5,6-tetrahydro-6-phenylimidiazo(2,1-\LC/b\UC/)thiazole hydrochloride
CT  - Prolongation of chemotherapeutically induced remission of a syngeneic murine leukemia by L-2,3,5,6-tetrahydro-6-phenylimidiazo(2,1-\LC/b\UC/)thiazole hydrochloride
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/04/01/
VL  - 35
IS  - Apr
SP  - 927
EP  - 931
SN  - 00085472
AD  - Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-0098; Language: English; Trade Name: 1,3-bis(2-Chloroethyl)-1-nitrosourea--L-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride; Generic Name: Carmustine; Tetramisole; Chemical Name: Tetramisole--5036-02-2 Carmustine--154-93-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine (10:00); AHFS Class: Antineoplastic agents tetramisole; References: 28; Journal Coden: CNREA8; Section Heading: Drug Interactions; Preliminary Drug Testing
N2  - L-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride (tetramisole; I), when used with 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine; II) resulted in a significantly higher percentage of long term leukemia-free survivor mice. The additive effect provided by I treatment was evident during the immunosuppressed period induced by II treatment and when tumor load was minimal. Treatment with I alone did not appear to possess any significant antitumor effect. The beneficial effect of I treatment may be attributable to the immunostimulatory activity reported for this drug. It appears to be an excellent candidate for use as an immunostimulant in combination therapy.
KW  - Tetramisole--interactions-;
KW  - Carmustine--interactions-;
KW  - Drug interactions--tetramisole and carmustine--leukemias, increased survival, comparison, tetramisole alone, in mice;
KW  - Drug interactions--carmustine and tetramisole--leukemias, increased survival, comparison, tetramisole alone, in mice;
KW  - Antineoplastic agents--carmustine--interactions, tetramisole, leukemias, increased survival, comparison, tetramisole alone, in mice;
KW  - Antineoplastic agents--tetramisole--interactions, carmustine, leukemias, increased survival, comparison, tetramisole alone, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lippman, M. M.;
AU  - Laster, W. R.;
AU  - Abbott, B. J.;
AU  - Venditti, J.;
AU  - Baratta, M.;
T1  - Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma
CT  - Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/04/01/
VL  - 35
IS  - Apr
SP  - 939
EP  - 945
SN  - 00085472
AD  - Drug Evaluation Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-0502; Language: English; Trade Name: NSC-170105; Generic Name: Macromomycin B; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents macromomycin B; References: 10; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing
N2  - Mice bearing either L1210 or P388 leukemia, or B16 melanoma responded to IP injections of macromomycin B (NSC-170105; I) with significant increases in life-span. The maximal increases in life-span obtained in these experiments were 37% for L1210, 68% for P388 and 120% for B16. In addition, there were 7 of 30 cures for varying doses of I in the B16 melanoma. Activity of over 50% increase in life-span in B16 was obtained with a daily IP injection on days 1-9 of 16-40 mg/kg. Animals that had received SC implanted Lewis lung tumors responded to either single or repeated injections (8-16 mg/kg) given at the site of tumor implant by a marked reduction in growth of the primary tumor, increased life-span, and some cures. The reported activity of I against L1210 and P388 leukemias, B16 melanoma, and Lewis lung carcinoma make it a good candidate for development for clinical trial against human solid tumors. Responder analysis, a method of evaluating activity against solid tumors, is also presented.
KW  - Macromomycin B--leukemia-;
KW  - Antineoplastic agents--macromomycin B--leukemia, melanoma, and Lewis lung carcinoma, effects, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pearson, J. W.;
AU  - Perk, K.;
AU  - Chirigos, M. A.;
AU  - Torgersen, J. A.;
T1  - Drug therapy against a transplantable guinea pig leukemia
CT  - Drug therapy against a transplantable guinea pig leukemia
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/04/01/
VL  - 35
IS  - Apr
SP  - 1093
EP  - 1098
SN  - 00085472
AD  - Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-6100; Language: English; Trade Name: Cytoxan; Generic Name: Cyclophosphamide; Chemical Name: Cyclophosphamide--6055-19-2 Mercaptopurine--6112-76-1 Semustine--13909-09-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mercaptopurine (10:00); AHFS Class: Antineoplastic agents semustine and cyclophosphamide (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 21; Journal Coden: CNREA8; Section Heading: Investigational Drugs
N2  - The effects of 6 clinically active drugs were tested against a transplantable leukemia in inbred strain 2 guinea pigs. Cytoxan (cyclophosphamide; I) and mercaptopurine were found to elicit a therapeutic response against this leukemia based on complete tumor regression of the established tumor as well as a substantial increase in survival time. Animals dying in the untreated control and drug-treated groups revealed typical generalized lymphoblastic leukemia. However, only I-treated animals that had relapsed exhibited central nervous system involvement originating from the arachnoid membrane. A 2-drug combination of I and semustine (II) was found not only to prevent meningeal leukemia development but also to cure all animals from their leukemia. This observation was based on a complete clinical, hematological, and histopathological remission period up to 176 days. The administration of II alone was observed not only to control the systemic leukemia but also to prevent central nervous system involvement. No relapses occurred after the first remission period was achieved in the groups of animals that received II.
KW  - Cyclophosphamide--alone and with semustine-;
KW  - Mercaptopurine--leukemias-;
KW  - Semustine--and cyclophosphamide-;
KW  - Antineoplastic agents--mercaptopurine--leukemias, transplantable, effects, in guinea pigs;
KW  - Antineoplastic agents--semustine and cyclophosphamide--leukemias, transplantable, effects, in guinea pigs;
KW  - Antineoplastic agents--cyclophosphamide--alone and with semustine, effects, transplantable leukemia, in guinea pigs;
KW  - Combined therapy--semustine and cyclophosphamide--leukemias, transplantable, in guinea pigs;
KW  - Combined therapy--cyclophosphamide and semustine--leukemias, transplantable, in guinea pigs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kerbel, R. S.
AU  - Birbeck, M. S. C.
AU  - Robertson, D.
AU  - Cartwright, P.
T1  - ULTRASTRUCTURAL AND SEROLOGICAL STUDIES ON THE RESISTANCE OF ACTIVATED B CELLS TO THE CYTOTOXIC EFFECTS OF ANTI-IMMUNOGLOBULIN SERUM.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1975/04//
VL  - 20
IS  - 1
M3  - Article
SP  - 161
EP  - 177
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either the source of antiserum or complement, or on the presence of a mitotic inhibitor, colcemid. Immunoperoxidasestaining-electron microscopy techniques were applied to assess whether there was any conspicuous difference between unstimulated versus mitogen-stimulated, mitotic cells with respect to density or distribution of cell surface Ig. No such differences were found; furthermore, mitotic cells showed rapid classical 'patch and cap' formation of cell surface Ig when incubated with anti-Ig at room temperature, indicating the retention of fluid membrane dynamics by lymphocytes in this stage of the cell cycle. In contrast to this cytotoxic resistance. T or B lymphocytes in mitosis were found to be as sensitive, or more so, to lysis by various other antisera when compared to non-mitotic cells. Thus the resistance of mitotic B cells to the cytotoxic effects of anti-Ig serum seems unique and appears independent of any conspicuous quantitative or qualitative change in ceil surface Ig. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - B cells
KW  - ANTI-immunoglobulin autoantibodies
KW  - MITOGENS
KW  - MITOSIS
KW  - IMMUNOGLOBULIN G
KW  - ANTIGENS
N1  - Accession Number: 16100799; Kerbel, R. S. 1,2 Birbeck, M. S. C. 3 Robertson, D. 3 Cartwright, P. 3; Affiliation:  1: Fellow of The National Cancer Institute of Canada.  2: Department of Pathology, Queen's University, Kingston, Ontario, Canada.  3: Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London.; Source Info: Apr1975, Vol. 20 Issue 1, p161; Subject Term: B cells; Subject Term: ANTI-immunoglobulin autoantibodies; Subject Term: MITOGENS; Subject Term: MITOSIS; Subject Term: IMMUNOGLOBULIN G; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Elin, R. J.;
AU  - Vesell, E. S.;
AU  - Wolff, S. M.;
T1  - Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance
CT  - Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1975/04/01/
VL  - 17
IS  - Apr
SP  - 447
EP  - 457
SN  - 00099236
AD  - Lab. of Clinical Investigation, National Institute of Allergy and Infectious Diseases, N.I.H. and Dept. of Pharmacology, Bethesda, Maryland and Milton S. Hershey Medical Center, Pennsylvania State Univ. College of Medicine, Hershey, Pennsylvania
N1  - Accession Number: 12-5808; Language: English; Chemical Name: Antipyrine--60-80-0; References: 38; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The plasma half-life and metabolic clearance rate of antipyrine were determined in 33 normal volunteers during a basal state and during fever induced with a single IM injection of etiocholanolone (I). After the 14 normal volunteers who achieved significant fever, 11 experienced prolonged plasma antipyrine half-life after a single oral does of 10 mg/kg and decreased antipyrine metabolic clearance rate. There was no significant change in these mean values in 19 normal volunteers who failed to develop significant fever. Plasma antipyrine half-life prolongation was probably due to impaired hepatic metabolism during I-induced fever, although no correlation was observed between the magnitude of fever and the extent to which plasma antipyrine half-life was prolonged. Failure to obtain such a correlation may be attributable to the very small range of temperature elevation, extending from 37.9 DG C to 39.2 DG C, in the group of 14 subjects achieving significant I-induced fever. A higher dose of antipyrine (18 mg/kg) supressed induction of fever; antipyrine is the only orally administered drug thus far shown to be effective in repressing fever.
KW  - Antipyrine--blood levels-;
KW  - Blood levels--antipyrine--half-life, and effects, fever induced by etiocholanolone, in humans;
KW  - Half-life--antipyrine--blood levels, and effects, fever induced by etiocholanolone, in humans;
KW  - Metabolism--antipyrine--blood levels, and effects, fever induced by etiocholanolone, in humans;
KW  - Excretion--antipyrine--blood levels, and effects on fever induced by etiocholanolone, in humans;
KW  - Mechanism of action--antipyrine--metabolism, and effects on fever induced by etiocholanolone, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Reiter, E. O.;
AU  - Kulin, H. E.;
T1  - Plasma testosterone response to short term human chorionic gonadotropin administration in men with follicle-stimulating hormone suppressed by exogenous estrogen
CT  - Plasma testosterone response to short term human chorionic gonadotropin administration in men with follicle-stimulating hormone suppressed by exogenous estrogen
JO  - Fertility and Sterility (USA)
JF  - Fertility and Sterility (USA)
Y1  - 1975/04/01/
VL  - 26
IS  - Apr
SP  - 340
EP  - 345
SN  - 00150282
AD  - Reprints: Dept. of Pediatrics, Univ. of South Florida College of Medicine, All Children's Hospital, St. Petersburg, Florida 33701
AD  - Reproduction Research Branch, National Institute of Child Health and Human Development, N.I.H., Bethesda, Maryland 20014
N1  - Accession Number: 12-6535; Language: English; References: 18; Journal Coden: FESTAS; Human Indicator: Yes; Section Heading: Pharmacology
N2  - To investigate the role of follicle stimulating hormone in Leydig cell function, 6 men were given 4 daily injections of 4,000 IU human chorionic gonadotropin (I) while receiving oral ethinyl estradiol. The peak testosterone levels were contrasted to the results obtained in 7 men who received I without additional exogenous steroid treatment. Urinary and plasma follicle stimulating hormone was suppressed to 26% and 50%, respectively, of basal values by the estrogen treatment. Peak plasma testosterone determinations following I did not differ in the 2 groups. Additionally, an early pubertal boy had a normal I-induced testosterone rise while his urnary follicle stimulating hormone was suppressed by estradiol to lower than prepubertal levels. The data indicate that short term follicle stimulating hormone suppression does not alter testicular responsivity to short term I administration. A role for follicle stimulating hormone in Leydig cell testosterone production in men has yet to be demonstrated.
KW  - Gonadotropins--chorionic--human, effects on plasma testosterone levels via FSH suppression, in men;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Fauci, A.S.
T1  - Mechanisms of Corticosteroid Action on Lymphocyte Subpopulations I. REDISTRIBUTION OF CIRCULATING T AND B LYMPHOCYTES TO THE BONE MARROW.
JO  - Immunology
JF  - Immunology
Y1  - 1975/04//
VL  - 28
IS  - 4
M3  - Article
SP  - 669
EP  - 680
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The effect of corticosteroid administration on the redistribution of circulating lymphocytes was studied in the guinea-pig, since this species closely resembles man in its relative resistance to the lymphopenic effect of corticosteroids. A single intravenous injection of hydrocortisone (either 10 mg or 100 mg/kg) caused a profound but transient lymphocytopenia which was maximal at 4 hours following injection, with a return to normal counts by 24 hours. There was a proportionately greater decrease in circulating T lymphocytes compared to B lymphocytes, although both populations were diminished. Chronic cortisone acetate treatment (100 mg/kg subcutaneously for 7 days) caused a similar pattern of lymphocytopenia except that it was sustained during the period of chronically elevated plasma cortisol levels. The lymphocytes remaining in the circulation during the period of lymphocytopenia responded normally in vitro to the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen. There was very little effect of corticosteroid administration on the numbers, proportions, or mitogenic response of splenic lymphocytes. There was a dramatic increase in the bone marrow of proportions and absolute numbers of lymphocytes bearing surface T- and B-cell markers, as well as a marked increase in response of bone marrow lymphocytes to mitogenic stimulation during the period of maximal circulating lymphocytopenia caused by the administration of corticosteroids, especially chronic cortisone acetate. There was a preferential horning of reinfused 51Cr-labelled syngeneic peripheral blood lymphocytes to the bone marrow of corticosteroid-treated recipients. These studies demonstrate a redistribution of circulating lymphocytes to the bone marrow during corticosteroid treatment, resulting in an increase in immunocompetence of this compartment, while the peripheral blood lymphocyte compartment is quantitatively immunosuppressed due to a lymphocytopenia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADRENOCORTICAL hormones
KW  - LYMPHOCYTES
KW  - BONE marrow
KW  - GUINEA pigs
KW  - T cells
KW  - B cells
N1  - Accession Number: 13371919; Fauci, A.S. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr75, Vol. 28 Issue 4, p669; Subject Term: ADRENOCORTICAL hormones; Subject Term: LYMPHOCYTES; Subject Term: BONE marrow; Subject Term: GUINEA pigs; Subject Term: T cells; Subject Term: B cells; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hurley, D. L.;
AU  - Barlow, J. E.;
AU  - Fauci, A. S.;
T1  - Experimental disseminated candidiasis. 2. Administration of glucocorticosteroids, susceptibility to infection and immunity
CT  - Experimental disseminated candidiasis. 2. Administration of glucocorticosteroids, susceptibility to infection and immunity
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1975/04/01/
VL  - 132
IS  - Apr
SP  - 393
EP  - 398
SN  - 00221899
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-2191; Language: English; References: 35; Journal Coden: JIDIAQ; Section Heading: Toxicity
N2  - A model of experimental disseminated candidiasis in inbred guinea pigs was used for study of the effects of both short and long acting glucocorticosteroid administration on the susceptibility to infection, the development of in vivo and in vitro parameters of cell mediated immunity, and the expression of already established candida specific, cell mediated immunity. Results revealed that long acting glucocorticoids markedly potentiate infection, increasing mortality and suppress already established cellular immune parameters. Short acting glucocorticosteroids did not potentiate infection and they affected neither the development nor the expression of immune parameters.
KW  - Steroids, cortico---toxicity--candidiasis, potentiation, and suppression of immune parameters, in guinea pigs;
KW  - Toxicity--steroids, cortico---candidiasis, potentiation, and suppression of immune parameters, in guinea pigs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cone, E. J.;
AU  - Gorodetzky, C. W.;
AU  - Yeh, S. Y.;
T1  - Biosynthesis, isolation, and identification of 6\b/-hydroxynaltrexone, a major human metabolite of naltrexone
CT  - Biosynthesis, isolation, and identification of 6\b/-hydroxynaltrexone, a major human metabolite of naltrexone
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1975/04/01/
VL  - 64
IS  - Apr
SP  - 618
EP  - 621
SN  - 00223549
AD  - Div. of Research Addiction Research Ctr., National Institute on Drug Abuse, Lexington, Kentucky 40511
N1  - Accession Number: 13-0811; Language: English; Chemical Name: Naltrexone--16590-41-3; References: 5; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
N2  - Pilot metabolic studies on naltrexone in the dog, rat and guinea pig were made to determine which animal produced the greatest amount of 6\b/-hydroxynaltrexone. The guinea pig was selected and used to produce the metabolite. Isolation and purification methods are described, and mass and infrared spectral data are presented for structural confirmation of the metabolite.
KW  - 6\b/-Hydroxynaltrexone--biosynthesis-;
KW  - Naltrexone--metabolism-;
KW  - Structure--6\b/-hydroxynaltrexone--isolation, and identification, in guinea pigs;
KW  - Spectrometry, infrared--6\b/-hydroxynaltrexone--structure, in guinea pigs;
KW  - Spectrometry, mass--6\b/-hydroxynaltrexone--structure, in guinea pigs;
KW  - Metabolism--naltrexone--biosynthesis, 6\b/-hydroxynaltrexone, isolation and identification, in guinea pigs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Graepel, P H
AU  - Henson, D E
AU  - Pratt, A W
T1  - Comments on the use of the systematized nomeclature of pathology
JO  - Methods of Information in Medicine
JF  - Methods of Information in Medicine
Y1  - 1975/04//
VL  - 14
IS  - 2
M3  - Article
SP  - 72
EP  - 75
SN  - 00261270
AB  - Any discussion of the use of the systematized nomenclature of pathology (snop) requires comprehension of the principles of organization of snop. Snop is a categorized nomenclature which lists 'names' of elements and concepts of pathology. Snop contains four lists of pathology names and concepts known as topography, morphology, etiology and function. Clearly, snop is not a diagnostic code or a coded medical terminology; to use snop the user must specify the coding structure. Thus snop is a basis for building a medical data code. The advantage of a categorized nomenclature is that it is possible to construct a well-defined information space for medical data based on the semantic value of the data and apart from some predetermined numeric code where terms are assigned as a function of the number structure. Thus it has been possible to explore the automatic processing of pathology language data. An automatic encoding capabality has been used at nih to encode surgical pathology data these encoded data were used to study the deficiencies of snop and to evaluate new structures for a truly categorized nomenclature of medicine. This new lexical structure can only be achieved if the pathologists waive traditional practices of assigning names to concepts of pathology and allow for new dimensions of medical ways of thinking which go beyond pure morphology.
N1  - Accession Number: ISTA1001488; Graepel, P H 1; Henson, D E; Pratt, A W; Affiliations: 1 : Division Of Computer Research And Technology And Laboratory Of Pathology, National Cancer Institute, National Institutes Of Health, Bethesda, Maryland.;  Source Info: April 1975, Vol. 14 Issue 2, p72; Note: Update Code: 1000; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2013-42018-004
AN  - 2013-42018-004
AU  - Lystad, Mary Hanemann
T1  - Violence at home: A review of the literature.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1975/04//
VL  - 45
IS  - 3
SP  - 328
EP  - 345
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Lystad, Mary Hanemann, National Institute of Mental Health, 5600 Fishers Lane, Rockville, NY, US, 20852
N1  - Accession Number: 2013-42018-004. PMID: 1096636 Partial author list: First Author & Affiliation: Lystad, Mary Hanemann; Division of Special Mental Health Programs, National Institute of Mental Health, Rockville, NY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Domestic Violence; Psychological Assessment; Social Norms; Sociocultural Factors. Minor Descriptor: Intimacy; Social Issues. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 18. Issue Publication Date: Apr, 1975. 
AB  - Studies on family violence have analyzed the phenomenon from psychological, social, and cultural perspectives. A review of the literature shows that the available evidence is not contradictory, leading to the conclusion that a comprehensive theory of violence at home must take into account factors at these several levels, placing individual functioning within the social group and within the culture norms by which the group operates. A theory of violence at home, and suggestions for further research, are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - violence at home
KW  - psychological perspectives
KW  - social perspectives
KW  - cultural perspectives
KW  - culture norms
KW  - intimacy
KW  - 1975
KW  - Domestic Violence
KW  - Psychological Assessment
KW  - Social Norms
KW  - Sociocultural Factors
KW  - Intimacy
KW  - Social Issues
KW  - 1975
DO  - 10.1111/j.1939-0025.1975.tb02544.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42018-027
AN  - 2013-42018-027
AU  - Shore, Milton F.
T1  - Review of Existing patterns of services for alcoholism and drug dependence: Report of a study; Comparison and evaluation of methods of treatment and rehabilitation for drug dependence and abuse: Report on a working group; Psychiatry and primary medical care: Report on a working group; and The role of the psychologist in mental health services: Report on a working group.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1975/04//
VL  - 45
IS  - 3
SP  - 505
EP  - 506
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42018-027. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alcoholism; Mental Health Services; Primary Health Care; Rehabilitation; Treatment. Minor Descriptor: Mental Health; Psychiatry; Psychologists. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Ozarin, Lucy. Existing patterns of services for alcoholism and drug dependence: Report of a study=(EURO 5437 IV.) 146 pp. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. No authorship indicated. Comparison and evaluation of methods of treatment and rehabilitation for drug dependence and abuse: Report on a working group=(EURO 5423 IV.) 103 pp. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. No authorship indicated. Psychiatry and primary medical care: Report on a working group=(EURO 5427 1.) 45 pp. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. No authorship indicated. The role of the psychologist in mental health services: Report on a working group=(EURO 5428 1.) 47 op. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. Page Count: 2. Issue Publication Date: Apr, 1975. 
AB  - Reviews the books, Existing Patterns of Services for Alcoholism and Drug Dependence: Report of a Study (1973), Comparison and Evaluation of Methods of Treatment and Rehabilitation for Drug Dependence and Abuse: Report on a Working Group (1973), Psychiatry and Primary Medical Care: Report on a Working Group (1973) and The Role of the psychologist in Mental Health Services: Report on a Working Group (1973). Any mention of the World Health Organization is bound to elicit in many professionals an immediate association to the classic work by John Bowl by, 'Maternal Care and Mental Health,' one of the earliest publications of the Organization, and one that has had a profound effect on the care of preschool children over the last two decades. The reports reviewed here are but a few of those available gratis from that office to those persons officially and professionally concerned about a specific field of mental health. The European Regional Office has gone far beyond just offering opportunities for people from different countries to exchange opinions. It has focused on broad studies of mental health structures in European countries with differing political, social, and economic conditions. The broad definition of mental health, which encompasses public health, social welfare, and educational elements, as well as the classic medical components, generates many approaches relevant to programs in the United States. These are work documents which focus on action. As a result they serve to narrow the gap between the theoretician and the practitioner, a gap that has been widening rather than narrowing. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - existing patterns
KW  - alcoholism
KW  - drug dependence
KW  - treatment processes
KW  - rehabilitation
KW  - medical care
KW  - mental health
KW  - 1975
KW  - Alcoholism
KW  - Mental Health Services
KW  - Primary Health Care
KW  - Rehabilitation
KW  - Treatment
KW  - Mental Health
KW  - Psychiatry
KW  - Psychologists
KW  - 1975
U2  - Ozarin, Lucy. (1973); Existing patterns of services for alcoholism and drug dependence: Report of a study; (EURO 5437 IV.) 146 pp. Regional Office, World Health Organization, Copenhagen, Denmark
U2  - No authorship indicated. (1973); Comparison and evaluation of methods of treatment and rehabilitation for drug dependence and abuse: Report on a working group; (EURO 5423 IV.) 103 pp. Regional Office, World Health Organization, Copenhagen, Denmark
U2  - No authorship indicated. (1973); Psychiatry and primary medical care: Report on a working group; (EURO 5427 1.) 45 pp. Regional Office, World Health Organization, Copenhagen, Denmark
U2  - No authorship indicated. (1973); The role of the psychologist in mental health services: Report on a working group; (EURO 5428 1.) 47 op. Regional Office, World Health Organization, Copenhagen, Denmark
DO  - 10.1037/h0098740
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SEGERLING, MARTIN
AU  - OHANIAN, SARKIS H.
AU  - BORSOS, TIBOR
T1  - Chemotherapeutic Drugs Increase Killing of Tumor Cells by Antibody and Complement.
JO  - Science
JF  - Science
Y1  - 1975/04/04/
VL  - 188
IS  - 4183
M3  - Article
SP  - 55
EP  - 57
SN  - 00368075
AB  - When the ascitic forms of two antigenically distinct guinea pig hepatomas induced by diethylnitrosamine are treated in vitro with chemotherapeutic drugs, their sensitivity to killing by xenogeneic antibody plus guinea pig complement increases. The effect is dependent on drug dose, is reversible, and does not appear to be due to increased antigen expression or fixation of the early acting components of guinea pig complement. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118802; SEGERLING, MARTIN 1; OHANIAN, SARKIS H. 1; BORSOS, TIBOR 1; Affiliations: 1: Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 4/1975, Vol. 188 Issue 4183, p55; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOONE, CHARLES W.
T1  - Malignant Hemangioendotheliomas Produced by Subcutaneous Inoculation of Balb/3T3 Cells Attached to Glass Beads.
JO  - Science
JF  - Science
Y1  - 1975/04/04/
VL  - 188
IS  - 4183
M3  - Article
SP  - 68
EP  - 70
SN  - 00368075
AB  - The Balb/3T3 mouse embryo cell line has been frequently used in cancer research as representative of nontumorigenic cells with the characteristic in vitro properties of postconfluence inhibition of cell division, low saturation density, and anchorage dependence. On the reasoning that anchorage dependence might also apply in vivo, each of nine mnice were subcutaneously inoculated with an average of 15,400 Balb/3T3 cells attached to two glass beads 3 millimeters in diameter. After 8 weeks, all the mice had developed large bloody tumors that microscopically proved to be hemangioendotheliomas. The inoculation of Balb/3T3 cells alone or beads alone produced no tumors. Transplants of each tumor into normal mice grew to kill the animal within 6 weeks. Tumor cells from collagenase- disaggregated tumor tissue had a plating efficiency of 21.2 percent conipared to that of normal adult subcutaneous fibroblasts of less than 0.1 percent. The tumor cells in vitro closely resembled Balb/3T3 cells in appearance and were tumorigenic at a dose of 105 cells. A second, repeat experimnent produced the same type of tumors grossly and microscopically in 17 of 25 mice between 99 and 211 days after inoculation of the Balb/3T3 cells attached to glass beads. These findings require a reassessmtient of the postulate that low saturation density, postconfluence of cell division, and amichorage dependence are characteristic in vitro properties only of nonneoplastic cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118808; BOONE, CHARLES W. 1; Affiliations: 1: Cell Biology Section, Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 4/1975, Vol. 188 Issue 4183, p68; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HENKART, MARYANNA
T1  - Light-Induced Changes in the Structure of Pigmented Granules in Aplysia Neurons.
JO  - Science
JF  - Science
Y1  - 1975/04/11/
VL  - 188
IS  - 4184
M3  - Article
SP  - 155
EP  - 157
SN  - 00368075
AB  - Pigmented granules in Aplysia neurons prepared in the dark contain material that appears to be composed of 50-angstrom globules and a precipitate, probably a calcium salt. On illumination the globules rearrange into paracrystalline arrays and membrane-like lamellae. The morphologic transformation may be related to calcium release from the granules, and the released calcium may mediate the light-evoked hyperpolarization described by others. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118842; HENKART, MARYANNA 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/11/1975, Vol. 188 Issue 4184, p155; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHECHTER, I.
AU  - MCKEAN, D. J.
AU  - GUYER, R.
AU  - TERRY, W.
T1  - Partial Amino Acid Sequence of the Precursor of Immunoglobulin Light Chain Programmed by Messenger RNA in vitro.
JO  - Science
JF  - Science
Y1  - 1975/04/11/
VL  - 188
IS  - 4184
M3  - Article
SP  - 160
EP  - 162
SN  - 00368075
AB  - The five proteins programmed in a cell-free system by a mouse kappa light chain messenger RNA were labeled with [³H]leucine and subjected to amino acid sequence analyses. In all five proteins, 20 amino acid residues precede the amino terminus of the mature protein, indicating that there is one major point for the initiation of messenger RNA translation. The abundance (30 percent) of leucine residues in the extra piece (leucine at positions 6, 7, 8, 11, 12, and 13) indicates that this moiety is hydrophobic. Furthermore, it seems that the precursor may have an additional extra piece at the carboxyl terminus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118844; SCHECHTER, I. 1; MCKEAN, D. J. 2; GUYER, R. 3; TERRY, W. 3; Affiliations: 1: Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel; 2: Department of Medical Genetics, University of Wisconsin, Madison 53706; 3: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/11/1975, Vol. 188 Issue 4184, p160; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ransom, B. R.;
AU  - Barker, J. L.;
T1  - Pentobarbital modulates transmitter effects on mouse spinal neurones grown in tissue culture
CT  - Pentobarbital modulates transmitter effects on mouse spinal neurones grown in tissue culture
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1975/04/24/
VL  - 254
IS  - Apr 24
SP  - 703
EP  - 705
AD  - Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20014
N1  - Accession Number: 13-1107; Language: English; Chemical Name: Pentobarbital--76-74-4; Therapeutic Class: (28:04); AHFS Class: Anesthetics pentobarbital; References: 18; Publication Type: Letters; Journal Coden: NATUAS; Section Heading: Pharmacology; Abstract Author: William H. Jeffery
N2  - General anesthetics depress postsynaptic excitatory transmission in the vertebrate central and peripheral nervous systems, although preserving or prolonging both presynaptic and postsynaptic inhibition. Using intracellular recording from mouse spinal neurones grown in tissue culture, it is shown that pentobarbital depresses glutamate excitation and prolongs \g/-aminobutyric acid inhibition in most cells, through a postsynaptic mechanism.
KW  - Pentobarbital--anesthesia-;
KW  - Anesthetics--pentobarbital--mechanism of action, discussion;
KW  - Mechanism of action--pentobarbital--anesthesia, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - WALLACE, G. D.
AU  - FRENKEL, J. K.
T1  - Besnoitia Species (Protozoa, Sporozoa, Toxoplasmatidae): Recognition of Cyclic Transmission by Cats.
JO  - Science
JF  - Science
Y1  - 1975/04/25/
VL  - 188
IS  - 4186
M3  - Article
SP  - 369
EP  - 371
SN  - 00368075
AB  - Isosporan oocysts, measuring 13 by 16 micrometers, from a cat in Hawaii produced Besnoitia cysts in tissues of mice and rats. Feeding these cysts to cats led to oocyst shedding after 11 to 13 days, continuing for a mean of 11 days. This indicates a two-host cycle for Besnoitia, adding an intestinal phase and oocyst production by a carnivore to the already known tissue stages. Thus a representative of Besnoitia, similar to other species in cattle, horses, reindeer, impala, other mammals, and reptiles, has been shown to be a coccidian of cats, capable of being spread by fecal contamination. Besnoitia is the fourth mammalian tissue parasite, together with Toxoplasma, Hammondia, and Sarcocystis, found to produce isosporan-type oocysts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136165; WALLACE, G. D. 1; FRENKEL, J. K. 2; Affiliations: 1: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Honolulu, Hawaii 96806; 2: Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103; Issue Info: 4/25/1975, Vol. 188 Issue 4186, p369; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Oster, M. W.;
AU  - Gelrud, L. G.;
AU  - Lotz, M. J.;
AU  - Herzig, G. P.;
AU  - Johnston, G. S.;
T1  - Psoas abscess localization by gallium scan in aplastic anemia
CT  - Psoas abscess localization by gallium scan in aplastic anemia
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1975/04/28/
VL  - 232
IS  - Apr 28
SP  - 377
EP  - 379
AD  - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-4272; Language: English; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals gallium citrate; References: 9; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - This report is concerned with a patient with aplastic anemia and severe granulocytopenia in whom the gallium citrate Ga 67 scintiscan was useful in diagnosing a previously undetected inflammatory lesion.
KW  - Gallium citrate--Ga 67-;
KW  - Radiopharmaceuticals--gallium citrate--Ga 67, scintiscan, inflammatory lesion, in patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bender, R. A.;
AU  - Bleyer, W. A.;
AU  - Frisby, S. A.;
AU  - Oliverio, V. T.;
T1  - Alteration of methotrexate uptake in human leukemia cells by other agents
CT  - Alteration of methotrexate uptake in human leukemia cells by other agents
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/05/01/
VL  - 35
IS  - May
SP  - 1305
EP  - 1308
SN  - 00085472
AD  - Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 12-6147; Language: English; Chemical Name: Methotrexate--59-05-2 Hydrocortisone--50-23-7 Cephalothin--153-61-7 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate (68:04); AHFS Class: Steroids, cortico- hydrocortisone (10:00); AHFS Class: Antineoplastic agents vincristine; References: 15; Journal Coden: CNREA8; Section Heading: Drug Interactions
N2  - The uptake of methotrexate (I) and the effects of drugs known to either inhibit or enhance I transport in L1210 murine leukemia were studied in man by using blast cells from patients with acute myelogenous leukemia in vitro. I uptake was found to proceed slowly, requiring at least 160 min for cells to reach a steady state when extracellular I concentrations were 1 micromole. Efflux of I from preloaded cells required 80-120 min and the nonexchangeable or tightly bound fraction was 40% of the total intracellular drug. Utilizing doses that are estimates of achievable peak blood levels following single IV injection, cephalothin, 21 mcg/ml, and hydrocortisone, 20 mcg/ml, inhibited net I accumulation by 20 and 28%, respectively. Vincristine sulfate, at 8.3 and 0.083 mcg/ml enhanced I uptake by 54 and 33%, respectively, by inhibiting I efflux, thus increasing the level of intracellular drug in excess of the tightly bound fraction. The potential clinical implications of using I in combination with the above drugs for cancer chemotherapy are discussed.
KW  - Methotrexate--interactions-;
KW  - Hydrocortisone--interactions-;
KW  - Cephalothin--interactions-;
KW  - Vincristine--interactions-;
KW  - Drug interactions--methotrexate and cephalothin--effects, absorption in human blast cells, in vitro;
KW  - Drug interactions--methotrexate and hydrocortisone--effects, absorption in human blast cells, in vitro;
KW  - Drug interactions--methotrexate and vincristine--effects, absorption in human blast cells, in vitro;
KW  - Drug interactions--vincristine and methotrexate--effects, absorption in human blast cells, in vitro;
KW  - Drug interactions--hydrocortisone and methotrexate--effects, absorption in human blast cells, in vitro;
KW  - Drug interactions--cephalothin and methotrexate--effects, absorption in human blast cells, in vitro;
KW  - Absorption--methotrexate--interactions, effects, in human blast cells, in vitro;
KW  - Metabolism--methotrexate--interactions, effects on absorption in human blast cells, in vitro;
KW  - Blood levels--methotrexate--interactions, effects on absorption in human blast cells, in vitro;
KW  - Antineoplastic agents--methotrexate--interactions, effects on absorption in human blast cells, in vitro;
KW  - Steroids, cortico---hydrocortisone--interactions, methotrexate, effects on absorption by human blast cells, in vitro;
KW  - Antineoplastic agents--vincristine--interactions, methotrexate, effects on absorption by human blast cells, in vitro;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, D. S.;
AU  - Pestaner, L. C.;
AU  - Friedman, R. B.;
T1  - Laboratory oriented computerized drug information system
CT  - Laboratory oriented computerized drug information system
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1975/05/01/
VL  - 9
IS  - May-Sep
SP  - 182
EP  - 189
SN  - 00928615
AD  - Clinical Pathology Dept., Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 13-5697; Language: English; References: 6; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2  - The structure and uses of the Computerized Listing of Abnormal and Unusual Drug Effects (CLAUDE), developed by the National Institutes of Health, are discussed. CLAUDE was developed to facilitate the correct interpretation of laboratory data by physicians and clinical laboratory scientists. The data base contains approximately 17,500 effects, both in vivo and in vitro, for 1500 drugs on laboratory tests.
KW  - Computerized Listing of Abnormal and Unusual Drug Effects--design--and applications, discussion;
KW  - Drug information--Computerized Listing of Abnormal and Unusual Drug Effects--design, and applications, discussion;
KW  - Automation, data processing, computers--Computerized Listing of Abnormal and Unusual Drug Effects--design, and applications, discussion;
KW  - Drug interactions--tests, laboratory and drugs--Computerized Listing of Abnormal and Unusual Drug Effects;
KW  - Tests, laboratory--interactions--drugs, Computerized Listing of Abnormal and Unusual Drug Effects;
KW  - Drug interactions--drugs and tests, laboratory--Computerized Listing of Abnormal and Unusual Drug Effects;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bellicha, T. C.;
AU  - Campbell, K. A.;
T1  - Targeted information concept. The National Clearinghouse for Alcohol Information
CT  - Targeted information concept. The National Clearinghouse for Alcohol Information
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1975/05/01/
VL  - 9
IS  - May-Sep
SP  - 199
EP  - 205
SN  - 00928615
AD  - National Clearinghouse for Alcohol Information, National Institute on Alcohol Abuse and Alcoholism, Gaithersburg, Maryland 20760
N1  - Accession Number: 13-5382; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2  - The purpose, organization, and operation of the services of the National Clearinghouse for Alcohol Information are detailed. Problems in the acquisition, classification, and dissemination of alcohol related information are discussed as well as methods of identifying potential users of this specialized collection.
KW  - Alcohols, ethyl--drug information-;
KW  - National Clearinghouse for Alcohol Information--organization--and purpose, discussion;
KW  - Drug information--National Clearinghouse for Alcohol Information--organization, and purpose;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Leeds, A. A.;
T1  - International Reference Centers Network\M/an unusual information resource
CT  - International Reference Centers Network\M/an unusual information resource
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1975/05/01/
VL  - 9
IS  - May-Sep
SP  - 219
EP  - 223
SN  - 00928615
AD  - International Reference Center for Information on Psychotropic Drugs, Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Ln., Rockville, Maryland 20852
N1  - Accession Number: 13-6329; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2  - The organization, publications, and activities of the International Reference Centers Network for Information on Psychotropic Drugs are discussed as a model system for international cooperation in the exchange of scientific information.
KW  - International Reference Centers Network for Information on Psychotropic Drugs--organization--publications, and activities, discussion;
KW  - Literature--International Reference Centers Network for Information on Psychotropic Drugs--publications, discussion;
KW  - Drug information--International Reference Centers Network for Information on Psychotropic Drugs--organization, publications and activities, discussion;
KW  - Psychotherapeutic agents--literature--International Reference Centers Network for Information on Psychotropic Drugs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schneider, J. H.;
T1  - International cancer data bank as a potential source of drug, carcinogenic, and toxicologic information
CT  - International cancer data bank as a potential source of drug, carcinogenic, and toxicologic information
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1975/05/01/
VL  - 9
IS  - May-Sep
SP  - 233
EP  - 238
SN  - 00928615
AD  - Office of International Affairs, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-5696; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2  - The working plans for the various products and services of the International Cancer Research Data Bank (ICRDB) and an overview of the flow of information through the system are presented. The 4 segments of the ICRDB program are described with special emphasis being given to the Cancer Information Dissemination and Analysis (CIDA) segment. CIDA embodies the active program of information dissemination which includes SDI services to cancer researchers and the CANCERLINE information network. Other segments of the program are concerned with scientist-to-scientist communication, clinical data methods, and support for special information projects at the NCI.
KW  - International Cancer Research Data Bank--services--discussion;
KW  - Drug information--International Cancer Research Data Bank--services, discussion;
KW  - Cancer--drug information--International Cancer Research Data Bank, services;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lachter, S. B.;
T1  - Acquisition of drug abuse information for the National Clearinghouse for Drug Abuse Information
CT  - Acquisition of drug abuse information for the National Clearinghouse for Drug Abuse Information
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1975/05/01/
IS  - May-Sep
SN  - 00928615
AD  - National Clearinghouse for Drug Abuse Information, National Institute on Drug Abuse, 11400 Rockville Pike, Rockville, Maryland 20852
N1  - Accession Number: 13-5375; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2  - A list of publication titles which provide relevant information on drug abuse in the United States is given. The titles of the publications are classified under the following headings: scientific journal literature, drug abuse newsletter, popular magazines, underground press, dissertation literature, government reports, books, and law and legislation.
KW  - Drug abuse--information--sources, for National Clearinghouse for Drug Abuse Information;
KW  - Drug information--abuse--sources, for National Clearinghouse for Drug Abuse Information;
KW  - National Clearinghouse for Drug Abuse Information--sources--literature;
KW  - Literature--drug information--sources, for National Clearinghouse for Drug Abuse Information;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Cameron-Otero, Rafael D.
AU  - Franklin, Richard M.
T1  - Structure and Synthesis of a Lipid-Containing Bacteriophage.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1975/05//May75 Part 1
VL  - 53
IS  - 2
M3  - Article
SP  - 343
EP  - 348
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Several physical and chemical parameters of bacteriophage PM2 have been measured. The sedimentation constant was determined to be s20,w° = 293 S. The buoyant density in sucrose at 20 °C was 1.24 g cm-3 and in CsCl at 25 °C was 1.29 g cm-3. The high-speed equilibrium centrifugation method of Yphantis (1964) was used to measure the molecular weight of PM2. The necessary auxiliary parameters were also determined. A value of 0.771 ± 0.005 cm3 g-1 for the apparent specific volume at constant chemical potential in 1 M sodium chloride has been obtained by pychometry; the viral concentration was determined using the absorption coefficient at 260 nm (4.60 ± 0.10 cm2 mg-1), which in turn was calculated from the phosphorous content of the virus (17.89 ± 0.28 μg of P per mg dry weight of virus). The molecular weight of PM2 determined with these parameters is (44.1 ± 1.2 × 106). From the phosphorous content of the virus, the percentage of phosphorus known to be in its DNA (Camerini­Otero and Franklin, 1972), and the molecular weight of the bacteriophage, we have calculated a molecular weight for PM2 DNA of 6.26 × 106, which confirms values determined using empirical relationships. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BACTERIOPHAGES
KW  - MICROBIOLOGY
KW  - BACTERIOLOGY
KW  - VIRUSES
KW  - LIPIDS
KW  - BIOMOLECULES
KW  - PHOSPHORUS
KW  - SALT
N1  - Accession Number: 15801960; Cameron-Otero, Rafael D. 1,2 Franklin, Richard M. 1,3; Affiliation:  1: The Public Health Research Institute of the City of New York  2: Laboratory of Molecular Biology, National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland, U.S.A. 20014  3: Abteilung Strukturbiologie, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland; Source Info: May75 Part 1, Vol. 53 Issue 2, p343; Subject Term: BACTERIOPHAGES; Subject Term: MICROBIOLOGY; Subject Term: BACTERIOLOGY; Subject Term: VIRUSES; Subject Term: LIPIDS; Subject Term: BIOMOLECULES; Subject Term: PHOSPHORUS; Subject Term: SALT; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Powell, John A.
AU  - Whalen, John J.
AU  - Levis, William R.
T1  - STUDIES ON THE CONTACT SENSITIZATION OF MAN WITH SIMPLE CHEMICALS.  !V. Timing of Skin Reactivity, Lymphokine Production, and Blastogenesis Following Rechallenge with Dinotrochlorobenzene using an Automated Microassay.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/05//
VL  - 64
IS  - 5
M3  - Article
SP  - 357
EP  - 363
SN  - 0022202X
AB  - An automated microassay was adapted to the study of specific in vitro lymphocyte transformation to dinitrochlorohenzene (DNCB) erythrocyte complexes (DNCB-antigen). Studies of culture conditions indicated that in flat-bottomed microtiter culture plates, 0.2-ml cultures containing 4 × 1o5 leukocytes and a total culture time of 4 or 5 days yield satisfactory results for the relatively low responses seen with specific antigens such as DNCB-antigen. Cultures were incubated for 3 hr with tritiated thymidine and harvested with the Multiple Automated Sample Harvester (MASH II). The effect of DNCB rechallenge on in vitro lymphocyte transformation was studied using this automated microassay. DNCB rechallenge boosted the in vitro response to DNCB-antigen, and in leukocyte cultures from some subjects the blastogenic response tended to remain elevated longer than has been reported following primary sensitization with DNCB. During a primary sensitization with DNCB, in vitro lymphocyte transformation to DNCB-antigen converted at about the same time skin reactivity was first observed, usually after about 2 weeks. However, following patch test rechallenge, skin reactivity was maximal at 2 to 3 days, whereas in vitro lymphocyte transformation to DNCB-antigen was nearly undetectable at 2 to 3 days and increased rapidly during the second week. The induction of lymphokine production following patch test rechallenge manifested a time course similar to that observed for specific lymphocyte transformation to DNCB-antigen. While the reasons for the observed temporal relationships between skin reactivity, blastogenesis, and lymphokine production are still unknown, knowledge of these relationships may provide insight on mechanisms of cellular immunity in man. In addition, awareness of these temporal relationships may allow a more rational approach to the in vitro study of naturally occurring contact sensitizers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - LYMPHOCYTES
KW  - LEUCOCYTES
KW  - DINITROCHLOROBENZENE
KW  - ERYTHROCYTES
N1  - Accession Number: 12512289; Powell, John A. 1 Whalen, John J. 1 Levis, William R. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: May75, Vol. 64 Issue 5, p357; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: DINITROCHLOROBENZENE; Subject Term: ERYTHROCYTES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12512289
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kahn, C. R.;
AU  - Levy, A. G.;
AU  - Gardner, J. D.;
AU  - Miller, J. V.;
AU  - Gorden, P.;
T1  - Pancreatic cholera: beneficial effects of treatment with streptozotocin
CT  - Pancreatic cholera: beneficial effects of treatment with streptozotocin
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1975/05/01/
VL  - 292
IS  - May 1
SP  - 941
EP  - 945
SN  - 00284793
AD  - Bldg. 10, Room 8N-240, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 12-4244; Language: English; References: 40; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Two patients with pancreatic cholera and islet cell carcinoma were treated with intra-arterial streptozotocin. Before therapy, each had stool volumes from 2 to 8 l/day and required 200 to 800 meq/day of supplemental potassium. After 3 to 5 doses of streptozotocin (1.5g/sq m), both stool volume and number and size of hepatic metastases decreased markedly. One patient has had normally formed stools for 12 months; the other had a 90% reduction in stool volume for 13 months with additional therapy. Both patients' serum potassium returned to normal without need for supplementation. Jejunal adenylate cyclase activity was normal in both, and plasma vasoactive intestinal peptide was detectable in only one. After chemotherapy, these findings showed no consistent change. Pharmacologic studies suggest that arterial administration increased either tumor or hepatic extraction (or both) of streptozotocin by 2 times and decreased renal exposure to this nephrotoxic drug by one third.
KW  - Streptozotocin--cholera-;
KW  - Cholera--streptozotocin--pancreatic, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chabner, B. A.;
AU  - Myers, C. E.;
AU  - Coleman, C. N.;
AU  - Johns, D. G.;
T1  - Clinical pharmacology of antineoplastic agents. Parts 1 and 2
CT  - Clinical pharmacology of antineoplastic agents. Parts 1 and 2
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1975/05/01/
VL  - 21
IS  - May 22; May 29
SP  - 1107
EP  - 1167
SN  - 00284793
AD  - Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. 6N110, Bethesda, Maryland 20014
N1  - Accession Number: 12-5282; Language: English; Trade Name: 5-Fluorouracil--Adriamycin; Generic Name: Fluorouracil; Doxorubicin; Chemical Name: Fluorouracil--51-21-8 Methotrexate--59-05-2 Doxorubicin--23214-92-8 Bleomycin--11056-06-7 Cyclophosphamide--6055-19-2 Cytidine--65-46-3 Nitrosourea--13010-20-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents fluorouracil (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents bleomycin (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents cytidine (10:00); AHFS Class: Antineoplastic agents deoxycytidine (10:00); AHFS Class: Antineoplastic agents nitrosourea; References: 159; Journal Coden: NEJMAG; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - Recent advances in the pharmacology of 5-fluorouracil, methotrexate, cytidine and deoxycytidine analogs, adriamycin (doxorubicin), bleomycin, nitrosoureas and cyclophosphamide are discussed.
KW  - Fluorouracil--pharmacology-;
KW  - Methotrexate--pharmacology-;
KW  - Doxorubicin--pharmacology-;
KW  - Bleomycin--pharmacology-;
KW  - Cyclophosphamide--pharmacology-;
KW  - Cytidine--derivatives-;
KW  - Deoxycytidine--derivatives-;
KW  - Nitrosourea--derivatives-;
KW  - Antineoplastic agents--fluorouracil--pharmacology, discussion;
KW  - Antineoplastic agents--methotrexate--pharmacology, discussion;
KW  - Antineoplastic agents--doxorubicin--pharmacology, discussion;
KW  - Antineoplastic agents--bleomycin--pharmacology, discussion;
KW  - Antineoplastic agents--cyclophosphamide--pharmacology, discussion;
KW  - Antineoplastic agents--cytidine--derivatives, pharmacology, discussion;
KW  - Antineoplastic agents--deoxycytidine--derivatives, pharmacology, discussion;
KW  - Antineoplastic agents--nitrosourea--derivatives, pharmacology, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Weiss, Theodore
AU  - Engel, Bernard T.
T1  - Evaluation of an Intra-Cardiac Limit of Learned Heart Rate Control.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1975/05//
VL  - 12
IS  - 3
M3  - Article
SP  - 310
EP  - 312
SN  - 00485772
AB  - Operant conditioning to Increase ventricular heart rate (VHR) was carried out in 3 subjects (Ss) with complete heart block. None or the Ss increased VHR consistently. This finding suggests that operant conditioning of VHR is possible only when the conduction path between atria and ventricles is not interrupted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OPERANT conditioning
KW  - HEART beat
KW  - HEART atrium
KW  - HEART block
KW  - CONDITIONED response
KW  - HEART diseases
KW  - Complete heart block
KW  - Operant conditioning
KW  - Ventricular heart rate.
N1  - Accession Number: 12320900; Weiss, Theodore 1 Engel, Bernard T. 1; Affiliation:  1: Section of Physiological Psychology, Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute of Child Health and Human, Development, Baltimore City Hospitals.; Source Info: May1975, Vol. 12 Issue 3, p310; Subject Term: OPERANT conditioning; Subject Term: HEART beat; Subject Term: HEART atrium; Subject Term: HEART block; Subject Term: CONDITIONED response; Subject Term: HEART diseases; Author-Supplied Keyword: Complete heart block; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Ventricular heart rate.; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1469-8986.ep12320900
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ALEXANDER, ELAINE L.
AU  - WETZEL, BRUCE
T1  - Human Lymphocytes: Similarity of B and T Cell Surface Morphology.
JO  - Science
JF  - Science
Y1  - 1975/05/16/
VL  - 188
IS  - 4189
M3  - Article
SP  - 732
EP  - 734
SN  - 00368075
AB  - When viewed by scanning electron microscopy, human lymphocytes fixed in suspension and processed with minimal cell loss appear uniformly cover with short microvilli. Contrary to previous reports, lymphocytes from subpopulatiot riched for T cells are villous and indistinguishable from B lymphocytes. Whereas lymphocyte surface architecture can change rapidly and substantially in response to environmental moditfications, such as contact with an underlying surface, these alterations are similar for both B and T cells and do not serve to distinguish these subpopulations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85118989; ALEXANDER, ELAINE L. 1; WETZEL, BRUCE 2; Affiliations: 1: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Dermatology Branch, National Cancer Institute; Issue Info: 5/16/1975, Vol. 188 Issue 4189, p732; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Gillespie, David
AU  - Gallo, Robert C.
T1  - RNA Processing and RNA Tumor Virus Origin and Evolution.
JO  - Science
JF  - Science
Y1  - 1975/05/23/
VL  - 188
IS  - 4190
M3  - Article
SP  - 802
EP  - 811
SN  - 00368075
N1  - Accession Number: 85119001; Gillespie, David 1; Gallo, Robert C.; Affiliations: 1: senior investigator, chief of Laboratory, Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 5/23/1975, Vol. 188 Issue 4190, p802; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Nathanson, J. A.;
AU  - Bloom, F. E.;
T1  - Lead-induced inhibition of brain adenyl cyclase
CT  - Lead-induced inhibition of brain adenyl cyclase
JO  - Nature (London)
JF  - Nature (London)
Y1  - 1975/05/29/
VL  - 255
IS  - May 29
SP  - 419
EP  - 420
AD  - Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeth's Hospital, Washington, D.C. 20032
N1  - Accession Number: 13-0938; Language: English; Chemical Name: Lead--7439-92-1; References: 23; Publication Type: Letters; Journal Coden: NATUAS; Section Heading: Toxicity; Pharmacology; Abstract Author: William H. Jeffery
N2  - It was found that very low concentrations of lead inhibit adenyl cyclase activity in rat brain tissue, but no biochemical basis could be clearly established for the behavioral defects associated with chronic lead toxicity.
KW  - Lead--toxicity-;
KW  - Toxicity--lead--behavioral defects, lack of biochemical basis, in rats;
KW  - Poisoning--lead--behavioral defects, lack of biochemical basis, in rats;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Pearlin, Leonard I.
T1  - STATUS INEQUALITY AND STRESS IN MARRIAGE.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1975/06//
VL  - 40
IS  - 3
M3  - Article
SP  - 344
EP  - 357
SN  - 00031224
AB  - Emotional stresses that are experienced In marriage are traced to difference: in spouses' status origins, Linking status differences to such stress are a number of Intervening conditions. People to whom status advancement is important and who have married mates of lower status are apt to have a sense of loss that leads, us turn, to a disruption of reciprocity, expressiveness, affection and value sharing In marital exchange. Such disruptions then act as immediate antecedents to emotional stress. It is through this process that the status order of the larger society can reach out to have a deleterious influence on the emotional states arising out of marital transactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RECIPROCITY (Commerce)
KW  - STRESS (Psychology)
KW  - MARRIAGE
KW  - MARRIED people
KW  - FRIENDSHIP
KW  - MENTAL health
N1  - Accession Number: 14894355; Pearlin, Leonard I. 1; Affiliations: 1: Laboratory of Socio-Environmental Studies, National Institute of Mental Health.; Issue Info: Jun75, Vol. 40 Issue 3, p344; Thesaurus Term: RECIPROCITY (Commerce); Subject Term: STRESS (Psychology); Subject Term: MARRIAGE; Subject Term: MARRIED people; Subject Term: FRIENDSHIP; Subject Term: MENTAL health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Layard, M. W. J.
T1  - The Generalized Jackknife Statistic (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1975/06//
VL  - 70
IS  - 350
M3  - Book Review
SP  - 486
SN  - 01621459
AB  - Reviews the book "The Generalized Jackknife Statistic," by H.L. Gray and W.R. Sehucany.
KW  - STATISTICS
KW  - JACKKNIFE (Statistics)
KW  - NONFICTION
KW  - GRAY, H. L.
KW  - SCHUCANY, W. R.
KW  - SEHUCANY, W. R.
KW  - GENERALIZED Jackknife Statistic, The (Book)
N1  - Accession Number: 4604431; Layard, M. W. J. 1; Affiliations: 1: National Cancer Institute.; Issue Info: Jun75, Vol. 70 Issue 350, p486; Thesaurus Term: STATISTICS; Subject Term: JACKKNIFE (Statistics); Subject Term: NONFICTION; Reviews & Products: GENERALIZED Jackknife Statistic, The (Book); People: GRAY, H. L.; People: SCHUCANY, W. R.; People: SEHUCANY, W. R.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Berg, Paul
AU  - Baltimore, David
AU  - Brenner, Sydney
AU  - Roblin III, Richard O.
AU  - Singer, Maxine F.
T1  - Asilomar Conference on Recombinant DNA Molecules.
JO  - Science
JF  - Science
Y1  - 1975/06/06/
VL  - 188
IS  - 4192
M3  - Article
SP  - 991
EP  - 994
SN  - 00368075
N1  - Accession Number: 85119090; Berg, Paul 1; Baltimore, David 2; Brenner, Sydney 3; Roblin III, Richard O. 4; Singer, Maxine F. 5; Affiliations: 1: Professor of biochemistry, Department of Biochemistry, Stanford University Medical Center, Stanford, California; 2: American Cancer Society Professor of Microbiology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; 3: Member of Scientific Staff of Medical Research Council of United Kingdom, Cambridge, England; 4: Professor of microbiology and molecular genetics, Harvard Medical School, and assistant bacteriologist, Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts; 5: Head of Nucleic Acid Enzymology Section, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Issue Info: 6/ 6/1975, Vol. 188 Issue 4192, p991; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GOODMAN, DAVID B. P.
AU  - BLOOM, FLOYD E.
AU  - BATTENBERG, ELLENA R.
AU  - RASMUSSEN, HOWARD
AU  - DAVIS, WALTER L.
T1  - Immunofluorescent Localization of Cyclic AMP in Toad Urinary Bladder: Possible Intercellular Transfer.
JO  - Science
JF  - Science
Y1  - 1975/06/06/
VL  - 188
IS  - 4192
M3  - Article
SP  - 1023
EP  - 1025
SN  - 00368075
AB  - By use of an immunofluorescent cytochemical staining technique, adenosine 3',5'-monophosphate (cyclic A MP) has been localized in toad bladder epithelial cells. Within 2 minutes after addition of vasopressin, staining intensity increases in both mitochondria-rich and granular cells. This finding, taken together with the precise anatomieal relation between these two epithelial cell types and the observation that after separation of the two cell types vasopressin stimulates cyclic AMP accumulation in only mitochondria-rich cells, suggests that cyclic AMP may be transferred from mitochrondria-rich to granular cells as part of the response of the toad urinary bladder to vasopressin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85119117; GOODMAN, DAVID B. P. 1; BLOOM, FLOYD E. 2; BATTENBERG, ELLENA R. 2; RASMUSSEN, HOWARD 3; DAVIS, WALTER L. 4; Affiliations: 1: Departments of Pediatrics and Biochemistry, University of Pennsylvania Medical School, Philadelphia 19174; 2: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 3: Departments of Pediatrics and Biochemistry, University of Pennsylvania Medical School; 4: Department of Pathology, Baylor University Medical Center, Dallas, Texas 75226; Issue Info: 6/ 6/1975, Vol. 188 Issue 4192, p1023; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Canellos, G. P.;
T1  - Second malignancies complicating Hodgkin's disease in remission
CT  - Second malignancies complicating Hodgkin's disease in remission
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1975/06/07/
VL  - 1
IS  - Jun 7
SP  - 1294
SN  - 00237507
AD  - National Institutes of Health, National Cancer Institute, Medicine Branch, Bethesda, Maryland 20014
N1  - Accession Number: 12-6364; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2 Prednisone--53-03-2 Procarbazine--671-16-9 Vincristine--57-22-7; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2  - Two cases of leukemia are reported in patients who were being treated for Hodgkin's disease with extensive radiotherapy and chemotherapy, including the MOPP regimen (nitrogen mustard (mechlorethamine), vincristine, procarbazine and prednisone).
KW  - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW  - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW  - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW  - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW  - Drugs, adverse reactions--mechlorethamine, prednisone, procarbazine and vincristine--leukemias, in Hodgkin's disease patients;
KW  - Drugs, adverse reactions--prednisone, mechlorethamine, procarbazine and vincristine--leukemias, in Hodgkin's disease patients;
KW  - Drugs, adverse reactions--procarbazine, mechlorethamine, prednisone and vincristine--leukemias, in Hodgkin's disease patients;
KW  - Drugs, adverse reactions--vincristine, mechlorethamine, prednisone and procarbazine--leukemias, in Hodgkin's disease patients;
KW  - Combined therapy--antineoplastic agents--adverse reactions, leukemia, in Hodgkin's disease patients;
KW  - Antineoplastic agents--combined therapy--adverse reactions, leukemia, in Hodgkin's disease patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - VARMA, S. D.
AU  - MIKUNI, I.
AU  - KINOSHITA, J. H.
T1  - Flavonoids as Inhibitors of Lens Aldose Reductase.
JO  - Science
JF  - Science
Y1  - 1975/06/20/
VL  - 188
IS  - 4194
M3  - Article
SP  - 1215
EP  - 1216
SN  - 00368075
AB  - Flavonoids are effective inhibitors oftens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136203; VARMA, S. D. 1; MIKUNI, I. 1; KINOSHITA, J. H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20014; Issue Info: 6/20/1975, Vol. 188 Issue 4194, p1215; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - OKA, TAKAMI
AU  - TOPPER, YALE J.
T1  - Insulin-Unresponsive Tissues Respond To Superactive Insulin-Like Material.
JO  - Science
JF  - Science
Y1  - 1975/06/27/
VL  - 188
IS  - 4195
M3  - Article
SP  - 1317
EP  - 1319
SN  - 00368075
AB  - Insulin-like material prepared frprn +insu/in-Sepharose stimulates glucose oxidation by isolated diaphragm of C57Bij6J objob mice, but insulin does not. This material is much more effective than insulin on epididymal fat tissue from these mice. Insulin-/ ike material and insulin are equipotent on the corresponding tissues from lean littermates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136243; OKA, TAKAMI 1; TOPPER, YALE J. 1; Affiliations: 1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 6/27/1975, Vol. 188 Issue 4195, p1317; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Patel, A. R.;
AU  - Gori, G. B.;
T1  - Preparation and monitoring of marihuana smoke condensate samples
CT  - Preparation and monitoring of marihuana smoke condensate samples
JO  - Bulletin on Narcotics (USA)
JF  - Bulletin on Narcotics (USA)
Y1  - 1975/07/01/
VL  - 27
IS  - Jul-Sep
SP  - 47
EP  - 54
SN  - 0007523X
AD  - Meloy Laboratories, Inc., Springfield, Virginia 22151) (Reprints: National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 14-0637; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Cannabis--8063-14-7; References: 13; Journal Coden: BNUNA5; Section Heading: Pharmaceutical Technology; Drug Analysis; Abstract Author: Douglas L. Thompson
N2  - The preparation of standard marihuana (cannabis) cigarettes 85 mm long and 25 mm in circumference using medium porosity paper, with no filter, and the production and gas chromatographic analysis of smoke condensate samples is described.
KW  - Cannabis--standards-;
KW  - Standards--cannabis--cigarettes, production and GLC analysis;
KW  - Cigarettes--cannabis--standards, production and GLC analysis;
KW  - Chromatography, gas--cannabis--cigarettes, and standards;
KW  - Manufacturing--cannabis--cigarettes, standards and GLC analysis;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Flamm, W. G.;
T1  - Test systems for assessing mutagenic potential of chemical substances
CT  - Test systems for assessing mutagenic potential of chemical substances
JO  - J. Assoc. Off. Anal. Chem.
JF  - J. Assoc. Off. Anal. Chem.
Y1  - 1975/07/01/
VL  - 58
IS  - Jul
SP  - 668
EP  - 671
AD  - National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-0222; Language: English; References: 9; Journal Coden: JANCA2; Section Heading: Methodology; Abstract Author: Douglas L. Thompson
N2  - Bacterial and animal test systems that can be used for the detection and evaluation of mutagenic substances are briefly discussed.
KW  - Toxicity--methodology--mutagens, test systems;
KW  - Mutagens--methodology--tests, bacterial and animal;
KW  - Chemicals--mutagens--tests, bacterial and animal;
KW  - Methodology--toxicity--mutagens, bacterial and animal test systems;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Ugel, Arthur R.
T1  - BOVINE KERATOHYALIN: ANATOMICAL, HISTOCHEMICAL, ULTRASTRUCTURAL, IMMUNOLOGIC, AND BIOCHEMICAL STUDIES.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/07//
VL  - 65
IS  - 1
M3  - Article
SP  - 118
EP  - 126
SN  - 0022202X
AB  - Salt extraction studies showed that keratohyalin (KH) could be solubilized and extracted from fresh bovine hoof epidermis. The solubility of KH varied in relation to the molarity of the salt solution used for extraction. Using this information, the extracted KH was aggregated in vitro by dialyzing the high salt extract against distilled water. Histochemical, ultrastructural, and immunologic studies of the resultant particles or macroaggregates showed that the latter had the same properties and immunogenicity as the KH granule in situ and produced antibodies against it. Fractionation of the macroaggregates by polyacrylamide gel electrophoresis demonstrated that the macroaggregates were composed of sets of 20 polymers whose subunits or monomers had a molecular weight of 16,900. Amino acid analyses showed that the macroaggregates and the various fractionated polymers were similar and that the protein had 116 amino acid residues. Serine, arginine, glycine, glutamic acid, and histidine constituted 78% of all residues, and serine alone represented 27%. The molecular weight by amino acid analyses was 16,150 after correction for the 8% ribonucleic acid which appears to he complexed to the protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMINO acids
KW  - POLYACRYLAMIDE
KW  - GLUTAMIC acid
KW  - HISTOCHEMISTRY
KW  - IMMUNOLOGY
KW  - ULTRASTRUCTURE (Biology)
N1  - Accession Number: 12598085; Ugel, Arthur R. 1; Affiliation:  1: Dermatology Branch, National Cancer institute, National Institutes of Health, Bethesda, Maryland; Source Info: Jul75, Vol. 65 Issue 1, p118; Subject Term: AMINO acids; Subject Term: POLYACRYLAMIDE; Subject Term: GLUTAMIC acid; Subject Term: HISTOCHEMISTRY; Subject Term: IMMUNOLOGY; Subject Term: ULTRASTRUCTURE (Biology); Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1523-1747.ep12598085
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mulvihill, J. J.;
AU  - Ridolfi, R. L.;
AU  - Schultz, F. R.;
AU  - Borzy, M. S.;
AU  - Haughton, P. B. T.;
T1  - Hepatic adenoma in Fanconi anemia treated with oxymetholone
CT  - Hepatic adenoma in Fanconi anemia treated with oxymetholone
JO  - Journal of Pediatrics (USA)
JF  - Journal of Pediatrics (USA)
Y1  - 1975/07/01/
VL  - 87
IS  - Jul
SP  - 122
EP  - 124
SN  - 00223476
AD  - A-521 Landow Bldg., National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-0348; Language: English; Chemical Name: Oxymetholone--434-07-1; References: 16; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Charles D. Ponte
N2  - A case report is presented of oxymetholone (I) and prednisone (II) therapy in a 13-year-old white male who, at age 8.5 years, was diagnosed as having Fanconi pancytopenia. I, 20-60 mg/day, was initiated in combination with II. The patient showed clinical improvement for 15 months following therapy. Five months prior to his death, hyperbilirubinemia (23 mg/dl) and liver function abnormalities occurred. Two weeks later the patient died from intracranial hemorrhage and pseudomonas sepsis. A single hepatic adenoma was observed at autopsy. The possible causual relationship between androgenic therapy and hepatic tumors is cited, as evidenced by previous reports. However, the primary etiological relationships are as yet unknown. Hepatic adenomas appear to be nonmalignant; yet there should be cause for concern depending on size, location, and other factors. Angiography is recommended as an aid to diagnosis except where thrombocytopenia exists. When a diagnosis is made stoppage of the androgenic steroids is favored over surgery or radiation therapy.
KW  - Oxymetholone--contraindications-;
KW  - Toxicity--oxymetholone--anemias, Fanconi, fatal, in child;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Yeh, S. Y.;
AU  - McQuinn, R. L.;
T1  - GLC determination of heroin and its metabolites in human urine
CT  - GLC determination of heroin and its metabolites in human urine
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1975/07/01/
VL  - 64
IS  - Jul
SP  - 1237
EP  - 1239
SN  - 00223549
AD  - Div. of Research, Addiction Research Center, National Institute on Drug Abuse, Lexington, Kentucky 40511
N1  - Accession Number: 13-1764; Language: English; Trade Name: Heroin; Generic Name: Diacetylmorphine; Chemical Name: Diacetylmorphine--561-27-3 Morphine--57-27-2 Normorphine--466-97-7; References: 16; Publication Type: Notes; Journal Coden: JPMSAE; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2  - Heroin (diacetylmorphine) and its metabolites, 6-monoacetylmorphine, morphine, and normorphine, were determined in human urine with a gas-liquid chromatographic procedure.
KW  - Diacetylmorphine--and metabolites-;
KW  - 6-Monoacetylmorphine--excretion-;
KW  - Morphine--excretion-;
KW  - Normorphine--excretion-;
KW  - Chromatography, gas--diacetylmorphine--and metabolites, urinary excretion, in humans;
KW  - Excretion--diacetylmorphine--and metabolites, urinary, GLC, in humans;
KW  - Metabolism--diacetylmorphine--and metabolites, urinary excretion, GLC, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Williams Jr, Redford B.
AU  - Bittker, Thomas E.
AU  - Buchsbaum, Monte S.
AU  - Wynne, Lyman C.
T1  - Cardiovascular and Neurophysiologic Correlates of Sensory Intake and Rejection. I. Effect of Cognitive Tasks.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1975/07//
VL  - 12
IS  - 4
M3  - Article
SP  - 427
EP  - 433
SN  - 00485772
AB  - In this study of the relationship between sensory processing and cardiovascular function, five cardiovascular parameters were monitored during baseline periods and during tasks requiring either sensory intake or sensory rejection behavior on the part of 19 subjects. Sensory intake behavior was associated with a pattern of response similar to that seen with activation of peripheral sympathetic nerves--vasoconstriction in both the digit (skin) and forearm (skeletal muscle). In contrast, sensory rejection behavior was associated with vasodilation in the forearm and vasoconstriction in the digit. Individual differences is an EEG measure of characteristic ways of processing sensory information were predictably associated with differences in resting cardiovascular function. The association of sensory intake with a skeletal muscle vasoconstriction may help to extend our understanding of the physiology of sensory processing, since heretofore only heart rate and somatic motor activity have reliably differentiated sensory intake from sensory rejection behavior. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARDIOVASCULAR system
KW  - BLOOD circulation
KW  - NEUROPHYSIOLOGIC monitoring
KW  - SENSORY neurons
KW  - SKIN diseases
KW  - HEART beat
KW  - INDIVIDUAL differences
KW  - Augmenting and reducing of average evoked responses.
KW  - Forearm blood flow and vascular resistance
KW  - Individual differences
KW  - Sensory processing (intake and rejection)
N1  - Accession Number: 11685277; Williams Jr, Redford B. 1 Bittker, Thomas E. 1,2 Buchsbaum, Monte S. 1 Wynne, Lyman C. 1,3; Affiliation:  1: Laboratory of Clinical Psychobiology and Adult Psychiatry Branch, National Institute of Mental Health, Bethesda.  2: Arizona Health Plan, Phoenix, Arizona.  3: Department of Psychiatry, University of Rochester School of Medicine, Rochester, New York.; Source Info: Jul1975, Vol. 12 Issue 4, p427; Subject Term: CARDIOVASCULAR system; Subject Term: BLOOD circulation; Subject Term: NEUROPHYSIOLOGIC monitoring; Subject Term: SENSORY neurons; Subject Term: SKIN diseases; Subject Term: HEART beat; Subject Term: INDIVIDUAL differences; Author-Supplied Keyword: Augmenting and reducing of average evoked responses.; Author-Supplied Keyword: Forearm blood flow and vascular resistance; Author-Supplied Keyword: Individual differences; Author-Supplied Keyword: Sensory processing (intake and rejection); Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1469-8986.ep11685277
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bittker, Thomas E.
AU  - Buchsbaum, Monte S.
AU  - Williams Jr., Redford B.
AU  - Wynne, Lyman C.
T1  - Cardiovascular and Neurophysiologic Correlates of Sensory Intake and Rejection. II. Interview Behavior.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1975/07//
VL  - 12
IS  - 4
M3  - Article
SP  - 434
EP  - 438
SN  - 00485772
AB  - As part of a three task study of the influence of attentional style on cardiovascular response, 19 normal volunteers were given a 15-min interview during which systolic and diastolic blood pressure, digital pulse volume, heart rate, and forearm blood flow were recorded. At the same time two observers independently assessed five elements of the subjects' interview behavior; arousal, eye contact with the interviewer, self-revelation of interview center, attentiveness to the interviewer, and overall transactional engagement in the interview task. When subjects were divided into groups of interview attenders and nonattenders on the basis of interviewer ratings, attenders had a mean decrease in forearm blood flow and nonattenders a mean increase. These group differences extended across a word identification (sensory intake) and mental arithmetic (sensory rejection) task a well. When subjects were divided into groups of forearm blood flow increasers and decreasers, increasers displayed less attentiveness to the interviewer, less self-revelation, greater arousal, and less transactional engagement than did decreases (N=9). Attentiveness to the interviewer and transactional engagement were the two most sensitive behavioral discriminators in comparing the increaser and decreaser groups. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARDIOVASCULAR system
KW  - NEUROPHYSIOLOGIC monitoring
KW  - SENSORY neurons
KW  - BLOOD pressure
KW  - HEART beat
KW  - NEUROPHYSIOLOGY
KW  - Attention.
KW  - Cardiovascular response
KW  - Interview behavior
KW  - Sensory intake and rejection
N1  - Accession Number: 11685290; Bittker, Thomas E. 1 Buchsbaum, Monte S. 1 Williams Jr., Redford B. 1 Wynne, Lyman C. 1; Affiliation:  1: Adult Psychiatry Branch and Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda.; Source Info: Jul1975, Vol. 12 Issue 4, p434; Subject Term: CARDIOVASCULAR system; Subject Term: NEUROPHYSIOLOGIC monitoring; Subject Term: SENSORY neurons; Subject Term: BLOOD pressure; Subject Term: HEART beat; Subject Term: NEUROPHYSIOLOGY; Author-Supplied Keyword: Attention.; Author-Supplied Keyword: Cardiovascular response; Author-Supplied Keyword: Interview behavior; Author-Supplied Keyword: Sensory intake and rejection; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1469-8986.ep11685290
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11685290&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, J.
AU  - Nylen, M. U.
T1  - Dose and age dependent variations in effect of tetracycline  on enamel formation in rat.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1975/07//
VL  - 83
IS  - 4
M3  - Article
SP  - 209
EP  - 232
SN  - 0029845X
AB  - Incidence of rats with gross enamel lesions in response to tetracycline hydrochloride (TC) was studied in relationship to age, tooth type, and concentration of antibiotic in the injection fluid. Incidence was defined as percentage of animals with defects in at least one incisor or one molar. Serum levels were measured at various intervals in 4- and 75-day-old rats, which received a single i.p. injection with 130 mg/kg bw in concentrations of either 13 or 25 mg/ml saline. The study confirmed that the effect of TC on enamel varied with age of the animal and that the molar responded more readily than the incisor. Furthermore, the incidence was higher the higher the concentration of antibiotic. This effect appeared tied to a direct relationship between concentration and serum level. Serum levels declined more slowly in the younger than in the older rats, resulting in significantly higher levels 6, 24 and 48 h after dosing, which correlated with a more extensive labeling of the dentin in the young rats. The possible roles of serum levels, capillary supply and cell susceptibility are discussed in relation to differences in response with animal age, between tooth types, tooth surfaces and with age of the secretory cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TETRACYCLINE
KW  - DENTAL enamel
KW  - RATS as laboratory animals
KW  - DENTISTRY
KW  - ANTIBIOTICS
KW  - DENTAL therapeutics
KW  - <em>dental enamel</em>
KW  - <em>drugs</em>
KW  - <em>histology</em>
KW  - <em>microradiography</em>
KW  - <em>rat</em>
KW  - <em>spectrophotofluorometry</em>
KW  - <em>tetracyclines</em>
N1  - Accession Number: 13209265; Westergaard, J. 1 Nylen, M. U. 1; Affiliation:  1: Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Md., U.S.A.; Source Info: 1975, Vol. 83 Issue 4, p209; Subject Term: TETRACYCLINE; Subject Term: DENTAL enamel; Subject Term: RATS as laboratory animals; Subject Term: DENTISTRY; Subject Term: ANTIBIOTICS; Subject Term: DENTAL therapeutics; Author-Supplied Keyword: <em>dental enamel</em>; Author-Supplied Keyword: <em>drugs</em>; Author-Supplied Keyword: <em>histology</em>; Author-Supplied Keyword: <em>microradiography</em>; Author-Supplied Keyword: <em>rat</em>; Author-Supplied Keyword: <em>spectrophotofluorometry</em>; Author-Supplied Keyword: <em>tetracyclines</em>; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wiener, Jack
T1  - Schizophrenics in the New Custodial Community: Five Years After the Experiment (Book).
JO  - Social Work
JF  - Social Work
Y1  - 1975/07//
VL  - 20
IS  - 4
M3  - Book Review
SP  - 332
EP  - 333
PB  - Oxford University Press / USA
SN  - 00378046
AB  - Reviews the book "Schizophrenics in the New Custodial Community: Five Years After the Experiment," by Ann E. Davis, Simon Dinitz and Benjamin Pasamanick.
KW  - SCHIZOPHRENICS
KW  - NONFICTION
KW  - DAVIS, Ann E.
KW  - DINITZ, Simon
KW  - PASAMANICK, Benjamin
KW  - SCHIZOPHRENICS in the New Custodial Community: Five Years After the Experiment (Book)
N1  - Accession Number: 5267277; Wiener, Jack 1; Affiliation:  1: National Institute of Mental Health, Rockville, Maryland; Source Info: Jul75, Vol. 20 Issue 4, p332; Subject Term: SCHIZOPHRENICS; Subject Term: NONFICTION; Reviews & Products: SCHIZOPHRENICS in the New Custodial Community: Five Years After the Experiment (Book); People: DAVIS, Ann E.; People: DINITZ, Simon; People: PASAMANICK, Benjamin; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rauscher Jr., Frank J.
T1  - Research and the National Cancer Program.
JO  - Science
JF  - Science
Y1  - 1975/07/11/
VL  - 189
IS  - 4197
M3  - Article
SP  - 115
EP  - 119
SN  - 00368075
N1  - Accession Number: 85136294; Rauscher Jr., Frank J. 1; Affiliations: 1: Director, National Cancer Program, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; Issue Info: 7/11/1975, Vol. 189 Issue 4197, p115; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NELSON, RALPH
AU  - LCTZOW, ASTRID V.
AU  - KOLB, HELGA
AU  - GOURAS, PETER
T1  - Horizontal Cells in Cat Retina with Independent Dendritic Systems.
JO  - Science
JF  - Science
Y1  - 1975/07/11/
VL  - 189
IS  - 4197
M3  - Article
SP  - 137
EP  - 139
SN  - 00368075
AB  - Cat horizontal cells are retinal neurons with two functionally distinct parts; the cell body receives signals predominantly from cones, while the terminal arborization receives predominantly from rods. The long thin process connecting these parts neither generates impulses nor allows significant passive electrotonic conduction between them. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136313; NELSON, RALPH 1; LCTZOW, ASTRID V. 2; KOLB, HELGA 3; GOURAS, PETER 4; Affiliations: 1: Neurophysiology Section, Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 2: Institu für Allgemeine und Vergleichende Physiologie der Universitiät Wien, Schwarzspanierstrasse 17, 1090 Vienna, Austria; 3: Laboratory of Neurophysiology, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014; 4: Neurophysiology Section, Laboratory of Vision Research, National Eye Institute; Issue Info: 7/11/1975, Vol. 189 Issue 4197, p137; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GIMBRONE JR., MICHAEL A.
AU  - ALEXANDER, R. WAYNE
T1  - Angiotensin 11 Stimulation of Prostaglandin Production in Cultured Human Vascular Endothelium.
JO  - Science
JF  - Science
Y1  - 1975/07/18/
VL  - 189
IS  - 4198
M3  - Article
SP  - 219
EP  - 220
SN  - 00368075
AB  - Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Production is inhibited by indomethacin and stimulated by angiotensin I. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136343; GIMBRONE JR., MICHAEL A. 1; ALEXANDER, R. WAYNE 2; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; 2: Hypertension-Endocrine Branch, National Heart and Lung Institute, Bethesda, Maryland 20014; Issue Info: 7/18/1975, Vol. 189 Issue 4198, p219; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gimbrone, M. A.;
AU  - Alexander, R. W.;
T1  - Angiotension II stimulation of prostaglandin production in cultured human vascular endothelium
CT  - Angiotension II stimulation of prostaglandin production in cultured human vascular endothelium
JO  - Science
JF  - Science
Y1  - 1975/07/18/
VL  - 189
IS  - Jul 18
SP  - 219
EP  - 220
AD  - Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014 and Hypertension-Endocrine Branch, National Heart and Lung Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-0440; Language: English; Chemical Name: Angiotensin II--11128-99-7; References: 12; Journal Coden: SCIEAS; Section Heading: Pharmacology; Abstract Author: Larry N. Gever
N2  - Vasoactive octapeptide angiotensin II stimulates production of an immunoreactive prostaglandin E(I)-like material. Angiotensin II appears to act by increasing the de novo synthesis of I, rather than its passive release. By isolating homogeneous populations of human vasculature endothelium in culture, this cell type has been identified as a potential source of I secretion in response to angiotensin II. The production of this immunoreactive material is inhibited by indomethacin. Pathophysiologic factors that modulate secretion of I by the endothelial cell may be important in the local control of vascular tone, permeability, and platelet-dependent thrombotic phenomena.
KW  - Angiotensin II--effects-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - ANSLOW, RALPH O.
AU  - EWALD, BRUCE H.
AU  - PAKES, STEVEN P.
AU  - SMALL, J. DAVID
AU  - WHITNEY JR., ROBERT A.
T1  - Control of Infectious Diseases among Rodent Stocks.
JO  - Science
JF  - Science
Y1  - 1975/07/25/
VL  - 189
IS  - 4199
M3  - Article
SP  - 248
EP  - 248
SN  - 00368075
N1  - Accession Number: 88002689; ANSLOW, RALPH O. 1; EWALD, BRUCE H. 2; PAKES, STEVEN P. 3; SMALL, J. DAVID 4; WHITNEY JR., ROBERT A. 4; Affiliations: 1: Research Animal Resources Center, University of Wisconsin, Madison 53705; 2: Department of Laboratory Animal Medicine, Cornell University Medical College, New York 10021; 3: Animal Resources Center, University of Texas Southwestern Medical School, Dallas 75235; 4: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/25/1975, Vol. 189 Issue 4199, p248; Number of Pages: 2/5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Blot, W. J.;
AU  - Fraumeni, J. F.;
T1  - Arsenical air pollution and lung cancer
CT  - Arsenical air pollution and lung cancer
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1975/07/26/
VL  - 2
IS  - Jul 26
SP  - 142
EP  - 144
SN  - 00237507
AD  - National Cancer Institute, A521 Landow Bldg., Bethesda, Maryland 20014
N1  - Accession Number: 13-0229; Language: English; Chemical Name: Arsenic--7440-38-2; References: 15; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2  - Average mortality rates from lung cancer for White males and females in the U.S.A. for the period 1950-69 were significantly increased in counties with copper, lead, or zinc smelting and refining industries, but not in counties where other non-ferrous ores are processed. The excess mortality was not attributed to differences in geographic region, population density, urbanization, socioeconomic status, or other manufacturing processes. The findings suggest the influence of community air pollution from industrial emissions containing inorganic arsenic.
KW  - Arsenic--toxicity, environmental-;
KW  - Toxicity, environmental--arsenic--effects, industrial emissions, in humans;
KW  - Industry--arsenic--toxicity, environmental, emissions, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Padilla, Elena
AU  - Goldston, Stephen E.
T1  - Profiles of Physicians Trained in Schools of Public Health.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1975/08//
VL  - 65
IS  - 8
M3  - Article
SP  - 828
EP  - 836
PB  - American Public Health Association
SN  - 00900036
AB  - The physician who graduates from a school of public health differs in many respects from a private practitioner. A profile of public health physicians is presented. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PUBLIC health personnel
KW  - PUBLIC health schools
KW  - PHYSICIANS
KW  - MEDICAL personnel
KW  - MEDICAL education
KW  - PUBLIC health
KW  - MEDICAL care
KW  - INTERNSHIP programs
KW  - EMPLOYEE training
N1  - Accession Number: 5701272; Padilla, Elena 1 Goldston, Stephen E. 2; Affiliation:  1: Professor and Director, Health Planning, Policy, and Administration, Graduate School of Public Administration, New York University, New York, New York  2: Coordinator for Primary Prevention Programs, Division of Special Mental Health Programs, National Institute of Mental Health, Rockville, Maryland 20852; Source Info: Aug1975, Vol. 65 Issue 8, p828; Subject Term: PUBLIC health personnel; Subject Term: PUBLIC health schools; Subject Term: PHYSICIANS; Subject Term: MEDICAL personnel; Subject Term: MEDICAL education; Subject Term: PUBLIC health; Subject Term: MEDICAL care; Subject Term: INTERNSHIP programs; Subject Term: EMPLOYEE training; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carenzi, A.;
AU  - Gillin, J. C.;
AU  - Guidotti, A.;
AU  - Schwartz, M. A.;
AU  - Wyatt, R. J.;
AU  - \ET/;
T1  - Dopamine-sensitive adenylyl cyclase in human caudate nucleus
CT  - Dopamine-sensitive adenylyl cyclase in human caudate nucleus
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1975/08/01/
VL  - 32
IS  - Aug
SP  - 1056
EP  - 1059
AD  - National Institute of Mental Health, St. Elizabeths Hospital, WAW Building, Washington, D.C. 20032
N1  - Accession Number: 13-3252; Language: English; Trade Name: Intropin--Norepinephrine--Levophed--Haldol; Generic Name: Dopamine; Levarterenol; Levarterenol; Haloperidol; Chemical Name: Dopamine--51-61-6 Haloperidol--52-86-8; Therapeutic Class: (12:12); AHFS Class: Sympathomimetic agents dopamine (12:12); AHFS Class: Sympathomimetic agents levarterenol (28:16.08); AHFS Class: Tranquilizers haloperidol; References: 11; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - Low concentrations of dopamine (Intropin), stimulated striatal adenylyl cyclase activity from 16 autopsied human brains. Norepinephrine (levarterenol; Levophed) was about one-third as potent and histamine and serotonin were ineffective. Haloperidol (Haldol) inhibited dopamine's stimulatory activity on adenylyl cyclase. No difference in the level and activity of basal adenylyl cyclase in 9 control subjects and 7 chronic schizophrenics occurred after dopamine stimulation.
KW  - Dopamine--effects-;
KW  - Levarterenol--effects-;
KW  - Haloperidol--effects-;
KW  - Sympathomimetic agents--dopamine--effects, striatal adenylyl cyclase activity, in human brain tissue;
KW  - Sympathomimetic agents--levarterenol--effects, striatal adenylyl cyclase activity, in human brain tissue;
KW  - Tranquilizers--haloperidol--effects, dopamine stimulated striatal adenylyl cyclase activity, in human brain tissue;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Post, R. M.;
AU  - Fink, E.;
AU  - Carpenter, W. T.;
AU  - Goodwin, F. K.;
T1  - Cerebrospinal fluid amine metabolites in acute schizophrenia
CT  - Cerebrospinal fluid amine metabolites in acute schizophrenia
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1975/08/01/
VL  - 32
IS  - Aug
SP  - 1063
EP  - 1069
AD  - Section on Psychobiology, Adult Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm 3S 239, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 13-3705; Language: English; Trade Name: Benemid; Generic Name: Probenecid; Chemical Name: Probenecid--57-66-9; References: 94; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Probenecid (Benemid), 100 mg/kg/day in divided doses, was used in the study of homovanillic acid (I) cerebrospinal fluid levels in 20 schizophrenic patients 16-54 yr old. The use of this drug allowed I and 5-hydroxyindole acetic acid (II) to accumulate in the CSF. No alteration in central serotonin or norepinephrine metabolism was apparent following I and II accumulation.
KW  - Probenecid--effects-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carter, S. K.;
AU  - Wasserman, T. H.;
T1  - Chemotherapy of urologic cancer
CT  - Chemotherapy of urologic cancer
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1975/08/01/
VL  - 36
IS  - Aug (Suppl)
SP  - 729
EP  - 747
AD  - Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-3251; Language: English; References: 110; Publication Type: Review; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - The review of the status of evaluation of chemotherapeutic agents in the urologic malignancies reveals a largely neglected area of investigation. Except for testicular carcinomas, which are highly responsive to drug therapy, active agents have not been clearly established for the other urogenital tumor sites. Published information and data on file in the Cancer Therapy Evaluation Program of the NCI are reviewed, and studies currently in progress are outlined. Adequate clinical testing of the standard antitumor agents that are active against other human malignancies should receive high priority in future therapeutic trials in urologic cancer.
KW  - Antineoplastic agents--cancer--urologic, therapy, in patients;
KW  - Research--antineoplastic agents--urologic, review;
KW  - Methodology--antineoplastic agents--research, urologic cancer, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Macdonald, J. S.
AU  - Wundereich, J. R.
AU  - Yust, L.
AU  - Yankee, R. N.
T1  - COMPLEMENT-DEPENDENT AND CELL-DEPENDENT ANTIPLATELET HUMORAL ANTIBODY IN SERA FROM MULTI-TRANSFUSED PATIENTS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1975/08//
VL  - 21
IS  - 2
M3  - Article
SP  - 259
EP  - 266
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Sera from eight multi-transfused patients, who were resistant to platelet transfusions from allogeneic donors, were tested for antiplatelet humoral antibody. Complement-dependent cytotoxic humoral antibody against platelets was found in sera from six of eight patients. Cell-dependent cytotoxic humoral antibody against platelets was found in sera from four of seven of these patients. Sera from two patients had cell-dependent antiplatelet activity but no detectable complement-dependent and cell-dependent humoral immunity may be important pathways for in viro resistance to platelets. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLOOD platelets
KW  - IMMUNOGLOBULINS
KW  - BLOOD plasma
KW  - PATIENTS
KW  - IMMUNITY
KW  - PLASMA cells
N1  - Accession Number: 16021795; Macdonald, J. S. 1 Wundereich, J. R. 2 Yust, L. 3 Yankee, R. N. 4; Affiliation:  1: Department of Medicine, Georgetown University, Medical Centre, 3800 Reservoir Road, Washington, D.C. 20007, U.S.A.  2: Immunology Branch and Pediatric Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.  3: Children's Cancer Research Foundation, 35 Binney Street, Boston, Massachusetts 02115, U.S.A.  4: Department of Medicine, B. Ichilov Hospital, Tel Aviv, Israel; Source Info: Aug1975, Vol. 21 Issue 2, p259; Subject Term: BLOOD platelets; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD plasma; Subject Term: PATIENTS; Subject Term: IMMUNITY; Subject Term: PLASMA cells; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lutzner, Marvin A.
AU  - Hansen, Carl T.
T1  - SKIN BLISTERS AND HAIR LOSS IN A RAT MUTANT CALLED VIBRISSAELESS (vb).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1975/08//
VL  - 65
IS  - 2
M3  - Article
SP  - 212
EP  - 216
SN  - 0022202X
AB  - A radiation-induced autosomal recessive mutant in the rat called vibrissaeless (<em>vb</em>), has been described and studied. Mutants have abnormal hair growth, the hairs being reduced in number and length. Mutant animals form blisters which then erode, crust, and heal without scars. The blisters can be artificially produced by friction and result from intraepidermal separation which is suprabasilar in position. To date, we cannot correlate this abnormality in rats with any known inherited human blistering disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLISTERS
KW  - SKIN diseases
KW  - SCARS
KW  - GRANULATION tissue
KW  - RATS
N1  - Accession Number: 12598215; Lutzner, Marvin A. 1 Hansen, Carl T. 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland.; Source Info: Aug75, Vol. 65 Issue 2, p212; Subject Term: BLISTERS; Subject Term: SKIN diseases; Subject Term: SCARS; Subject Term: GRANULATION tissue; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12598215
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carter, S. K.;
AU  - Kershner, L. M.;
T1  - What you should know about drugs vs. cancer
CT  - What you should know about drugs vs. cancer
JO  - Pharmacy Times (USA)
JF  - Pharmacy Times (USA)
Y1  - 1975/08/01/
VL  - 41
IS  - Aug
SP  - 56
EP  - 66
SN  - 00030627
AD  - National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-2057; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Walter F. Stanaszek
N2  - The current status of cancer chemotherapy is discussed in terms of its history, mechanisms of action, general principles of drug combination, and combined modalities. A table of commercially available cancer chemotherapeutic drugs is presented, including mechanisms of action, dosage, toxicity, and major indications.
KW  - Antineoplastic agents--combined therapy--and mechanism of action, discussion;
KW  - Combined therapy--antineoplastic agents--and mechanism of action, discussion;
KW  - Mechanism of action--antineoplastic agents--and combined therapy, discussion;
KW  - History--antineoplastic agents--therapy, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Rhaese, Hans-Jürgen
AU  - Dichtelmüller, Herbert
AU  - Grade, Reinhardt
T1  - Studies on the Control of Development.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1975/08/15/Aug75 Part 2
VL  - 56
IS  - 2
M3  - Article
SP  - 385
EP  - 392
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Bacillus subtilis cells accumulate unusual phosphorylated substances at the end of logarithmic growth in a semi-synthetic medium. Two of these substances are guanosine 3′(2′-diphosphate 5′-diphosphate (ppGpp) and guanosine 3′(2′)-diphosphate 5′-triphosphate (pppGpp) which, in contrast to amino-acid-starved Escherichia coil cells, are not degraded in sporulating cells of B. subtilis after the addition of chloramphenicol. Moreover, inhibition of protein synthesis in growing cells of B. subtilis causes accumulation of ppGpp and pppGpp, which is also in contrast to E. coll. This was shown by isolation and characterization of substances produced in these cells after the addition of chloramphenicol. Other inhibitors of protein synthesis acting at the ribosomal level also cause the accumulation of ppGpp and pppGpp. There is no difference between the action of antibiotics affecting 50-S and/or 30-S ribosomal subunits, since chloramphenicol, tetracycline, erythromycin and neomycin cause the accumulation of almost equal amounts of these nucleotides. This apparently resolves the close connection between ppGpp accumulation and the rate of stable RNA synthesis, which was believed to exist also in B. subtilis because of the stringent response observed after amino acid starvation coupled with ppGpp accumulation. Antibiotics which inhibit protein synthesis differently than by affecting the ribosomes (puromycin) or which inhibit RNA (rifampicin) or DNA (nalidixic acid) synthesis do not cause ppGpp accumulation. The accumulation of ppGpp and pppGpp in the presence of charged tRNA provided by chloramphenicol treatment suggests that the signal for the synthesis of unusual nucleotides is an inhibition of the binding of tRNA (charged or uncharged) to the acceptor site of the ribosome. This activates the rel gcue product which forms ppGpp and pppGpp from GTP and ATP. Sporulating cells of B. subtilis without chloramphenicol treatment produce besides ppGpp and pppGpp other unusual substances, which are likely to be highly phosphorylated nucleotides contained adenine as base moiety. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BACILLUS subtilis
KW  - CELLS
KW  - NUCLEOTIDES
KW  - PROTEIN synthesis
KW  - PHOSPHORYLATION
KW  - TRANSFER RNA
N1  - Accession Number: 12750353; Rhaese, Hans-Jürgen 1,2 Dichtelmüller, Herbert 1,2 Grade, Reinhardt 1,2; Affiliation:  1: Arbeitsgruppe Molekulare Genetik im Fachberein Biologie, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main  2: Laboratory of Molecular Biology, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: Aug75 Part 2, Vol. 56 Issue 2, p385; Subject Term: BACILLUS subtilis; Subject Term: CELLS; Subject Term: NUCLEOTIDES; Subject Term: PROTEIN synthesis; Subject Term: PHOSPHORYLATION; Subject Term: TRANSFER RNA; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SIGGINS, G. R.
AU  - HENRIKSEN, S. J.
T1  - Analogs of Cyclic Adenosine Monophosphate: Correlation of Inhibition of Purkinje Neurons with Protein Kinase Activation.
JO  - Science
JF  - Science
Y1  - 1975/08/15/
VL  - 189
IS  - 4202
M3  - Article
SP  - 559
EP  - 561
SN  - 00368075
AB  - Cyclic adenosine monophosphate (cyclic AMP) and 11 derivatives were applied to rat cerebellar Purkinje cells by iontophoresis. Cyclic AMP inhibited 63 percent of the cells, while the 8-parachlorophenylthio- and 8-benzylthio- analogs of cyclic AMP inhibited the spontaneous firing of 92 and 80 percent oj cells, respectively. The ability of the 11 analogs to inhibit neuronal firing correlated (r = + .78) with their reported potency in activating cyclic AMP-dependent protein kinase. These results extend previous studies, pointing to the mediation by cyclic AMP of the noradrenergic inhibition of Purkinje neurons, and provide new physiological evidence that protein phosphorylation is a major step in the action of cyclic AMP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136455; SIGGINS, G. R. 1; HENRIKSEN, S. J. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/15/1975, Vol. 189 Issue 4202, p559; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MILLER, Louis H.
AU  - MASON, STEVEN J.
AU  - DVORAK, JAMES A.
AU  - MCGINNISS, MARY H.
AU  - ROTHMAN, IVAN K.
T1  - Erythrocyte Receptors for (Plasmodium knowlesi) Malaria: Duffy Blood Group Determinants.
JO  - Science
JF  - Science
Y1  - 1975/08/15/
VL  - 189
IS  - 4202
M3  - Article
SP  - 561
EP  - 563
SN  - 00368075
AB  - Duffy blood group negative human erythrocytes (FyFy) are resistant to infection by Plasmodium knowlesi, a simian malaria that infects Duffy positive human erythrocytes. The P. knowlesi resistance factor, Duffy negative erythrocytes, occurs in high frequency in West Africa, where the people are resistant to vivax malaria. This suggests that Duffy blood group determinants (Fya or Fyb) may be erythrocyte receptors for P. vivax. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136456; MILLER, Louis H. 1; MASON, STEVEN J. 1; DVORAK, JAMES A. 1; MCGINNISS, MARY H. 2; ROTHMAN, IVAN K. 2; Affiliations: 1: Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Blood Bank, Clinical Center, National Institutes of Health, Bethesda 20014; Issue Info: 8/15/1975, Vol. 189 Issue 4202, p561; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HODGKINSON, ROBERT
AU  - MARX, GERTIE F.
AU  - KAISER, IRWIN H.
AU  - KAY STANDLEY, KAY STANDLEY
AU  - KLEIN, ROBERT P.
AU  - SOULE II, A. BRADLEY
T1  - Local-Regional Anesthesia During Childbirth and Newborn Behavior.
JO  - Science
JF  - Science
Y1  - 1975/08/15/
VL  - 189
IS  - 4202
M3  - Article
SP  - 571
EP  - 572
SN  - 00368075
N1  - Accession Number: 85136461; HODGKINSON, ROBERT 1; MARX, GERTIE F. 1; KAISER, IRWIN H. 2; KAY STANDLEY, KAY STANDLEY 3; KLEIN, ROBERT P. 3; SOULE II, A. BRADLEY 3; Affiliations: 1: Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, New York 10461; 2: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine; 3: Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 8/15/1975, Vol. 189 Issue 4202, p571; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Baron, M.;
AU  - Gershon, E. S.;
AU  - Rudy, V.;
AU  - Jonas, W. Z.;
AU  - Buchsbaum, M.;
T1  - Lithium carbonate response in depression: prediction by unipolar/bipolar illness, average evoked response, catechol-O-transferase, and family history
CT  - Lithium carbonate response in depression: prediction by unipolar/bipolar illness, average evoked response, catechol-O-transferase, and family history
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1975/09/01/
VL  - 32
IS  - Sep
SP  - 1107
EP  - 1111
AD  - Dept. of Research, Jerusalem Mental Health Center, Israel and the Div. of Clinical and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland
N1  - Accession Number: 13-3423; Language: English; Chemical Name: Lithium carbonate--554-13-2; References: 46; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Bipolar depressed patients had significantly more frequent unequivocal responses than the unipolar patients in a double blind study of 23 hospitalized depressed subjects who received lithium carbonate at a therapeutic level between 0.8 to 1.0 meq/l of serum lithium concentration.
KW  - Lithium carbonate--blood levels-;
KW  - Blood levels--lithium carbonate--therapy, in unipolar and bipolar depressed patients;
KW  - Metabolism--lithium carbonate--blood levels, therapy, in unipolar and bipolar depressed patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Tormey, D. C.;
T1  - Combined chemotherapy and surgery in breast cancer: a review
CT  - Combined chemotherapy and surgery in breast cancer: a review
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1975/09/01/
VL  - 36
IS  - Sep
SP  - 881
EP  - 892
AD  - Medical Breast Cancer Service, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-3417; Language: English; References: 53; Publication Type: Review; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The current results of trials testing combined surgery and chemotherapy in patients with breast cancer is reviewed. Information concerning 8 trials utilizing 9 single agent regimens was obtained. The results at this time are conflicting. There appear to be differences among the regimens utilized in the various patient subsets. Some of the possible reasons for the observed differences, and their implications for future studies, are discussed.
KW  - Antineoplastic agents--and surgery--therapy, in breast cancer, review, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Achenbach, Thomas M.
AU  - Weisz, John R.
T1  - A Longitudinal Study of Relations between Outer-Directedness and IQ Changes in Preschoolers.
JO  - Child Development
JF  - Child Development
Y1  - 1975/09//
VL  - 46
IS  - 3
M3  - Article
SP  - 650
EP  - 657
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12188439; Achenbach, Thomas M. 1 Weisz, John R. 2; Affiliation:  1: National Institute of Mental Health  2: Cornell University; Source Info: Sep1975, Vol. 46 Issue 3, p650; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1467-8624.ep12188439
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rauscher, F. J.;
T1  - National Cancer Institute safety standards for research involving chemical carcinogens. Part 127
CT  - National Cancer Institute safety standards for research involving chemical carcinogens. Part 127
JO  - J. Chem. Educ.
JF  - J. Chem. Educ.
Y1  - 1975/09/01/
VL  - 52
IS  - Sep
SP  - A419
EP  - A425
AD  - National Cancer Program, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-1777; Language: English; Publication Type: Safety in the Chemical Laboratory; Journal Coden: JCEDA8; Section Heading: Methodology
KW  - Standards--safety--carcinogens, National Cancer Institute;
KW  - Safety--standards--carcinogens, National Cancer Institute;
KW  - Carcinogens--safety--standards, National Cancer Institute;
KW  - Toxicity--carcinogens--safety, National Cancer Institute standards;
KW  - Chemicals--carcinogens--standards, safety, National Cancer Institute;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - FELIX, EDWARD L.
AU  - LOYD, BETTY
AU  - COHEN, MAX H.
T1  - Inhibition of the Growth and Development of a Transplantable Murine Melanoma by Vitamin A.
JO  - Science
JF  - Science
Y1  - 1975/09/12/
VL  - 189
IS  - 4206
M3  - Article
SP  - 886
EP  - 888
SN  - 00368075
AB  - Vitamin A, given either orally or intraperitoneally, has a dramatic inhibitory effect on the growth and development of a highly immunogenic murine melanoma. This effect may be due to enhancement of antitumor immunity by vitamin A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136602; FELIX, EDWARD L. 1; LOYD, BETTY 1; COHEN, MAX H. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/12/1975, Vol. 189 Issue 4206, p886; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MILES, F. A.
AU  - FULLER, J. H.
T1  - Visual Tracking and the Primate Flocculus.
JO  - Science
JF  - Science
Y1  - 1975/09/19/
VL  - 189
IS  - 4207
M3  - Article
SP  - 1000
EP  - 1002
SN  - 00368075
AB  - Purkinje cells in the primate flocculus discharge specifically in relation to visual tracking, effectively generating a velocity profile of the target during pursuit. It is suggested that these neurons supply oculomotor centers with the velocity command signals needed to support pursuit eye movements. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136640; MILES, F. A. 1; FULLER, J. H. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/19/1975, Vol. 189 Issue 4207, p1000; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HOOVER, ROBERT
AU  - MASON, THOMAS J.
AU  - MCKAY, FRANK W.
AU  - FRAUMENI JR., JOSEPH F.
T1  - Cancer by County: New Resource for Etiologic Clues.
JO  - Science
JF  - Science
Y1  - 1975/09/19/
VL  - 189
IS  - 4207
M3  - Article
SP  - 1005
EP  - 1007
SN  - 00368075
AB  - Mapping of U.S. cancer mortality by county has revealed patterns of etiologic significance. Th'e patterns for bladder cancer in males point to industrial determinants: some are known (chemical manufacturing) but others (autom'obile and machinery manufacturing)' represent new leads for epidemiologic study.' By contrast, the geographic clusters of high rates of stomach cancer in both sexes are consistent with eth'nic susceptibility. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136642; HOOVER, ROBERT 1; MASON, THOMAS J. 1; MCKAY, FRANK W. 1; FRAUMENI JR., JOSEPH F. 1; Affiliations: 1: Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/19/1975, Vol. 189 Issue 4207, p1005; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Bowery, Thomas G.
T1  - REPRESENTING MINORITIES.
JO  - BioScience
JF  - BioScience
Y1  - 1975/10//
VL  - 25
IS  - 10
M3  - Letter
SP  - 608
EP  - 608
SN  - 00063568
AB  - A letter to the editor is presented in response to the article "Underrepresentation of Minorities in the Biological Sciences," in the May 1975 issue.
KW  - Letters to the editor
KW  - Minorities
N1  - Accession Number: 28049482; Bowery, Thomas G. 1; Affiliations: 1 : Director Division of Research Resources, National Institutes of Health, Bethesda, MD 20014;  Source Info: Oct1975, Vol. 25 Issue 10, p608; Subject Term: Letters to the editor; Subject Term: Minorities; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 476
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Adler, William H.
T1  - Aging and Immune Function.
JO  - BioScience
JF  - BioScience
Y1  - 1975/10//
VL  - 25
IS  - 10
M3  - Article
SP  - 652
EP  - 657
SN  - 00063568
AB  - The article focuses on research in the field of aging and immunity. It is reported that a major advance in immunology research techniques has been in tissue culture. It is informed that the technique has allowed investigators to move their attention from the intact organism to the tissues and cells of the immune system. It is reported that in the study of stem cell activity, some experiments show no defect in the number or differentiation potential of the cells in the aging host. According to the author, if the possible nonlymphoreticular causes of an environmental defect are ignored, it is possible to examine the various facets of the aging immune system that lead to decreased antibody production.
KW  - Life sciences
KW  - Aging -- Research
KW  - Immunology -- Research
KW  - Immune system
KW  - Immunoglobulins
KW  - Stem cells
KW  - Gerontology
KW  - Developmental biology
KW  - Medical care
N1  - Accession Number: 28049494; Adler, William H. 1; Affiliations: 1 : Laboratory of Cellular and Comparative Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, and the Baltimore City Hospitals, Baltimore, MD 21224;  Source Info: Oct1975, Vol. 25 Issue 10, p652; Thesaurus Term: Life sciences; Subject Term: Aging -- Research; Subject Term: Immunology -- Research; Subject Term: Immune system; Subject Term: Immunoglobulins; Subject Term: Stem cells; Subject Term: Gerontology; Subject Term: Developmental biology; Subject Term: Medical care; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 5211
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - NEWS
AU  - Fredrickson, Donald S.
T1  - Finding answers to health care problems: A job for researchers, practitioners, and the public.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1975/10//
VL  - 30
IS  - 10
M3  - Editorial
SP  - 43
EP  - 50
SN  - 0016867X
N1  - Accession Number: 17729442; Fredrickson, Donald S. 1; Source Information: Oct1975, Vol. 30 Issue 10, p43; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1476
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Miller, W. L.;
AU  - Doppman, J. L.;
AU  - Kaplan, A. P.;
T1  - Renal arteriography following systemic reaction to contrast material
CT  - Renal arteriography following systemic reaction to contrast material
JO  - J. Allergy Clin. Immunol.
JF  - J. Allergy Clin. Immunol.
Y1  - 1975/10/01/
VL  - 56
IS  - Oct
SP  - 291
EP  - 295
AD  - National Institute of Allergy and Infectious Diseases, NHLI, Bldg 10, Rm. 11N 246, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-6473; Language: English; Trade Name: Conray--Benadryl; Generic Name: Iothalamate meglumine; Diphenhydramine hydrochloride; Chemical Name: Diphenhydramine hydrochloride--147-24-0 Prednisone--53-03-2 Iothalamate meglumine--13087-53-1; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone and diphenhydramine hydrochloride (4:00); AHFS Class: Antihistamines diphenhydramine hydrochloride and prednisone; References: 16; Journal Coden: JACIBY; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2  - Pretreatment with 80 mg prednisone and 200 mg diphenhydramine HCl (Benadryl) daily for 3 days prior to arteriography and challenge with increasing quantities of IV iothalamate meglumine (Conray) allowed for successful performance of arteriography in a 15-yr-old female with severe hypertension (220/160), a patient who had 2 previous anaphylaxis-like reactions to contrast materials. Pretreatment with a steroid-antihistaminic regimen may protect patients when the alternatives to performance of radiographic contrast studies appear to provide no less risk.
KW  - Diphenhydramine hydrochloride--and prednisone-;
KW  - Prednisone--and diphenhydramine hydrochloride-;
KW  - Iothalamate meglumine--adverse reactions-;
KW  - Combined therapy--diphenhydramine hydrochloride and prednisone--adverse reactions, prevention in iothalamate arteriography patients s*r e23.4 = adverse reactions, prevention in iothalamate arteriography patients;
KW  - Combined therapy--prednisone and diphenhydramine hydrochloride--adverse reactions, prevention in iothalamate arteriography patients;
KW  - Steroids, cortico---prednisone and diphenhydramine hydrochloride--prevention, iothalamate adverse reactions, arteriography, patients;
KW  - Antihistamines--diphenhydramine hydrochloride and prednisone--prevention, iothalamate adverse reactions, arteriography, patients;
KW  - Roentgenographic agents--lothalamate meglumine--adverse reactions, prevention, using diphenhydramine and prednisone therapy, arteriography, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Malone, W. F.;
T1  - Occupational cancer control and prevention. Part 128
CT  - Occupational cancer control and prevention. Part 128
JO  - J. Chem. Educ.
JF  - J. Chem. Educ.
Y1  - 1975/10/01/
VL  - 52
IS  - Oct; Nov
SP  - A468
EP  - A511
AD  - Prevention Branch, Div. of Cancer Control and Rehabilitation, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-2116; Language: English; References: 38; Publication Type: Safety in the Chemical Laboratory; Journal Coden: JCEDA8; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Douglas L. Thompson
N2  - The objectives of a cancer prevention program are outlined. Sources of information on carcinogens are included. A list of carcinogens for which occupational safety and health standards have been issued is included as is a list of chemicals reviewed in International Agency for Research on Cancer monographs on the evaluation of the carcinogenicity of chemicals to men.
KW  - Toxicity, environmental--carcinogens--control, occupational, and cancer prevention;
KW  - Control--carcinogens--occupational;
KW  - Carcinogens--control--occupational, and cancer prevention;
KW  - Chemicals--carcinogens--control, occupational cancer, and prevention;
KW  - Information--carcinogens--sources;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06267-016
AN  - 2006-06267-016
AU  - Levitin, Teresa
T1  - Is One Role Enough? Are Two Too Many?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1975/10//
VL  - 20
IS  - 10
SP  - 788
EP  - 789
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06267-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Levitin, Teresa; National Institute of Mental Health, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Employment Status; Family; Mother Child Relations; Working Women. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Hoffman, Lois W.; Nye, F. Ivan. Lois W. Hoffman and F. Ivan Nye=San Francisco: Jossey-Bass, 1974. Pp. xiv + 272. $12.50; 1974. Page Count: 2. Issue Publication Date: Oct, 1975. 
AB  - Reviews the book, Working Mothers by Lois W. Hoffman and F. Ivan Nye (1974). Working Mothers is a timely, readable book that reviews and evaluates much of the literature on the effects of maternal employment. The literature in this area is largely inconsistent, incomplete, and atheoretical; a major strength of Working Mothers is that these problems are not ignored. 'The most distressing aspect of the current research situation is the lack of theory' and this book reflects that situation. The book is best when data are organized around general approaches or hypotheses, as in the chapter on the child, and least satisfactory when a model is proposed but neither adequately justified nor well integrated with the literature, as with the chapter on the family. Consequently, this book could be used at the undergraduate level and would be useful not only as a text for students in marriage and the family, women's studies, and related courses, but also as a reference for social science researchers and practitioners. The Bibliography is extensive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - working mothers
KW  - maternal employment
KW  - family
KW  - mother child relations
KW  - 1975
KW  - Employment Status
KW  - Family
KW  - Mother Child Relations
KW  - Working Women
KW  - 1975
U2  - Hoffman, Lois W.; Nye, F. Ivan. (1974); Lois W. Hoffman and F. Ivan Nye; San Francisco: Jossey-Bass, 1974. Pp. xiv + 272. $12.50
DO  - 10.1037/014289
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-41591-015
AN  - 2013-41591-015
AU  - Abion, Steven L.
AU  - Davenport, Yolande B.
AU  - Gershon, Elliot S.
AU  - Adland, Marvin L.
T1  - The married manic.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1975/10//
VL  - 45
IS  - 5
SP  - 854
EP  - 866
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Davenport, Yolande B., National Institute of Mental Health, 9000 Rockville Pike, Bldg. 10, Rm. 45239, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-41591-015. Partial author list: First Author & Affiliation: Abion, Steven L.; Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Group Psychotherapy; Major Depression; Therapeutic Processes; Interpersonal Relationships. Minor Descriptor: Clinical Psychology; Marriage; Psychodynamics. Classification: Affective Disorders (3211); Group & Family Therapy (3313). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Oct, 1975. 
AB  - In group psychotherapy and follow-up studies, the interpersonal relationships and psychodynamics of the married manic depressive patient and spouse were studied. Prominent among these subjects were massive denial of grief, rage, and dependency in the context of symbiotic relationships; and the absence of a father during early development. Clinical expressions of these factors are presented, and therapeutic implications are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical expressions
KW  - group psychotherapy
KW  - interpersonal relationships
KW  - manic depression
KW  - symbiotic relationships
KW  - therapeutic implications
KW  - marriage
KW  - psychodynamics
KW  - 1975
KW  - Bipolar Disorder
KW  - Group Psychotherapy
KW  - Major Depression
KW  - Therapeutic Processes
KW  - Interpersonal Relationships
KW  - Clinical Psychology
KW  - Marriage
KW  - Psychodynamics
KW  - 1975
DO  - 10.1111/j.1939-0025.1975.tb01213.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - FLIER, JEFFREY S.
AU  - KAHN, C. RONALD
AU  - ROTH, JESSE
AU  - BAR, ROBERT S.
T1  - Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance.
JO  - Science
JF  - Science
Y1  - 1975/10/03/
VL  - 190
IS  - 4209
M3  - Article
SP  - 63
EP  - 65
SN  - 00368075
AB  - Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002732; FLIER, JEFFREY S. 1; KAHN, C. RONALD 1; ROTH, JESSE 1; BAR, ROBERT S. 1; Affiliations: 1: Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/ 3/1975, Vol. 190 Issue 4209, p63; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KEBABIAN, JOHN W.
AU  - BLOOM, FLOYD E.
AU  - STEINER, ALTON L.
AU  - GREENGARD, PAUL
T1  - Neurotransmitters Increase Cyclic Nucleotides in Postganglionic Neurons: Immunocytochemical Demonstration.
JO  - Science
JF  - Science
Y1  - 1975/10/10/
VL  - 190
IS  - 4210
M3  - Article
SP  - 157
EP  - 159
SN  - 00368075
AB  - Dopamine increases adenosine 3',5'-monophosphate (cyclic AMP) but not guanosine 3',5'-monophosphate (cyclic GMP) in slices of bovine sympathetic ganglion; this increase is localized to the postganglionic neurons. Conversely, acetylcholine increases cyclic GMP but not cyclic AMP in the ganglion; this increase also occurs within postganglionic neurons. Thus, different neurotransmitters can selectively alter cyclic nucleotide levels within the same neuronal population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136692; KEBABIAN, JOHN W. 1; BLOOM, FLOYD E. 2; STEINER, ALTON L. 3; GREENGARD, PAUL 4; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neuropharmacology, St. Elizabeths Hospital, Washington, D.C.; 3: Department of Medicine, University of North Carolina, Chapel Hill 27514; 4: Department of Pharmacology, Yale Medical School, New Haven, Connecticut 06510; Issue Info: 10/10/1975, Vol. 190 Issue 4210, p157; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HANSEN, JAMES W.
AU  - HOFFMAN, HOWARD J.
AU  - ROSS, GRIFF T.
T1  - Monthly Gonadotropin Cycles in Premenarcheal Girls.
JO  - Science
JF  - Science
Y1  - 1975/10/10/
VL  - 190
IS  - 4210
M3  - Article
SP  - 161
EP  - 163
SN  - 00368075
AB  - Patterns of nocturnal excretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were investigated in 11 girls. A utoregressive digital filtering of low- and high-frequency variations was used to make patterns more apparent. Coincident FSH and LH surges, separated by an interval of 20 to 40 days, were seen in specimens from three of six postmenarcheal girls and three to five premenarcheal girls. This suggests that cyclic hypothalamic-pituitary-ovarian interactions occur before menarche. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136694; HANSEN, JAMES W. 1; HOFFMAN, HOWARD J. 1; ROSS, GRIFF T. 1; Affiliations: 1: Reproduction Research Branch and Biometry Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 10/10/1975, Vol. 190 Issue 4210, p161; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rosenoff, S. H.;
AU  - Brooks, E.;
AU  - Bostick, F.;
AU  - Young, R. C.;
T1  - Alterations in DNA synthesis in cardiac tissue induced by adriamycin (doxorubicin) in vivo\M/relationship to fatal toxicity
CT  - Alterations in DNA synthesis in cardiac tissue induced by adriamycin (doxorubicin) in vivo\M/relationship to fatal toxicity
JO  - Biochem. Pharmacol.
JF  - Biochem. Pharmacol.
Y1  - 1975/10/15/
VL  - 24
IS  - Oct 15
SP  - 1898
EP  - 1901
AD  - Cellular Kinetics Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-3505; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 21; Publication Type: Letters; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: Douglas L. Thompson
N2  - Doxorubicin was shown to inhibit DNA synthesis in mouse cardiac tissue. A single dose of 10 mg/kg produced an early, mild depression of DNA synthesis which returned to control levels after 12 hr, and was followed by a delayed depression of DNA synthesis in the heart which was temporally related to fatal toxicity. This depression is more marked at the more toxic dose of 20 mg/kg. In addition to the alterations seen in DNA synthesis, histologic sections of mouse hearts stained with hematoxylin-eosin after a single dose of 15 mg/kg showed myocytolytic changes, similar to those described in patients with daunorubicin induced cardiomyopathy.
KW  - Doxorubicin--toxicity-;
KW  - Toxicity--doxorubicin--cardiac, inhibition of DNA synthesis, in mice;
KW  - Antineoplastic agents--doxorubicin--toxicity, cardiac, inhibition of DNA synthesis, in mice;
KW  - Tissue levels--doxorubicin--toxicity, cardiac, inhibition of DNA synthesis, in mice;
KW  - Metabolism--doxorubicin--tissue levels, cardiac, inhibition of DNA synthesis, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - BARR, RONALD D.
AU  - WHANG-PENG, JACQUELINE
AU  - PERRY, SEYMOUR
T1  - Hemopoietic Stem Cells in Human Peripheral Blood.
JO  - Science
JF  - Science
Y1  - 1975/10/17/
VL  - 190
IS  - 4211
M3  - Article
SP  - 284
EP  - 285
SN  - 00368075
AB  - A population of lymphocytes, separable from the great majority by virtue of their larger size and their failure to exhibit the rosetting characteristic of thymus-dependent lymphocytes and bursa-equivalent cells, possess true pluripoteinality. On culture in vivo they proliferate and differentate into erythrocytic, granulocytic, and megakarvocvtic progeny. This may be the first clear demionstration of the primitive progenitor blood cell in man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002750; BARR, RONALD D. 1; WHANG-PENG, JACQUELINE 1; PERRY, SEYMOUR 2; Affiliations: 1: Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: National Institutes of Health, Bethesda, Maryland; Issue Info: 10/17/1975, Vol. 190 Issue 4211, p284; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ARINTS, JOHN
AU  - SIEKEVITZ, PHILIP
AU  - SHANNON, THOMAS A.
AU  - STETTEN JR., DEWITT
T1  - Controversial Areas of Research.
JO  - Science
JF  - Science
Y1  - 1975/10/24/
VL  - 190
IS  - 4212
M3  - Article
SP  - 328
EP  - 330
SN  - 00368075
N1  - Accession Number: 88002758; ARINTS, JOHN 1; SIEKEVITZ, PHILIP 2; SHANNON, THOMAS A. 3; STETTEN JR., DEWITT 4; Affiliations: 1: Department of Chemnistry, City College, City University of New York, New York 10031; 2: Department of Cell Biology. Rockefeller University, New York 10021; 3: Departmiient of Humanities. Worcester Polytechnic Institute, Worcester, Massachusetts Al1609; 4: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/24/1975, Vol. 190 Issue 4212, preceding p328; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEISSBACH, ARTHUR
AU  - BALTIMORE, DAVID
AU  - BOLLUM, FRED
AU  - CALLO, ROBERT
AU  - KORN, DAVID
T1  - Nomenclature of Eukaryotic DNA Polymerases.
JO  - Science
JF  - Science
Y1  - 1975/10/24/
VL  - 190
IS  - 4212
M3  - Article
SP  - 401
EP  - 402
SN  - 00368075
N1  - Accession Number: 88002775; WEISSBACH, ARTHUR 1; BALTIMORE, DAVID 2; BOLLUM, FRED 3; CALLO, ROBERT 4; KORN, DAVID 5; Affiliations: 1: Roche Institute of Molecular Biology, Nutlev, New Jersey 07110; 2: Massachusetts Institute of Technology Cambridge 02139; 3: University of Kentucky Medical Center, Lexington 40506; 4: National Cancer Institute, Bethesda, Maryland 20014; 5: Stanford University, Palo Alto, California 94305; Issue Info: 10/24/1975, Vol. 190 Issue 4212, p401; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - POST, ROBERT M.
AU  - GOODWIN, FREDERICK K.
T1  - Time-Dependent Effects of Phenothiazines on Dopamine Turnover in Psychiatric Patients.
JO  - Science
JF  - Science
Y1  - 1975/10/31/
VL  - 190
IS  - 4213
M3  - Article
SP  - 488
EP  - 489
SN  - 00368075
AB  - Psychiatric patients studied early during treatment with chlorpromazine and thioridazine demonstrated elevated probenecid-induced accumulations of homovanillic acid, a major dopamine metabolite, in cerebrospinalfluid. In those studied after longer periods of treatment with phenothiazines, homovanillic acid values were not elevated. This suggests that there are time-dependent effects of phenothiazines on dopamine turnover that may be relevant to the time course of antipsychotic efficacy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002797; POST, ROBERT M. 1; GOODWIN, FREDERICK K. 2; Affiliations: 1: Section on Psychobiology, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 10/31/1975, Vol. 190 Issue 4213, p488; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chatterju, D.;
AU  - Hiranaka, P. K.;
AU  - Gallelli, J. F.;
T1  - Stability of sodium oxacillin in intravenous solutions
CT  - Stability of sodium oxacillin in intravenous solutions
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1975/11/01/
VL  - 32
IS  - Nov
SP  - 1130
EP  - 1132
SN  - 00029289
AD  - Pharmacy Dept., Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 13-1073; Language: English; Trade Name: Glucose; Generic Name: Dextrose; Chemical Name: Oxacillin--66-79-5 Dextrose--5996-10-1; References: 7; Journal Coden: AJHPA9; Section Heading: Drug Stability
N2  - The influence of concentration, vehicle, dextrose (glucose) and temperature on the stability of sodium oxacillin (I) solutions was determined using a chemical kinetic approach. I degraded faster in dextrose solution than in sodium chloride injection. This finding was attributed to the catalytic effect of dextrose on I hydrolysis. Solutions of 1-50 mg/ml I in each vehicle were found to be stable for 24 hr at 23\DG/ C. The degradation of I in various dextrose solutions was independent of I concentration, and followed first order kinetics.
KW  - Oxacillin--injections-;
KW  - Dextrose--oxacillin-;
KW  - Injections--intravenous--oxacillin, stability, effects of concentration, vehicle, dextrose and temperature;
KW  - Stability--oxacillin--injections, IV, effects of concentration, vehicle, dextrose and temperature;
KW  - Concentration--oxacillin--injections, IV, effects on stability;
KW  - Vehicles--oxacillin--injections, IV, effects on stability;
KW  - Temperature--oxacillin--injections, IV, effects on stability;
KW  - Kinetics--oxacillin--injections, IV, stability, in dextrose solutions;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Prescott, James W.
T1  - BODY PLEASURE AND THE ORIGINS OF VIOLENCE.
JO  - Bulletin of the Atomic Scientists
JF  - Bulletin of the Atomic Scientists
Y1  - 1975/11//
VL  - 31
IS  - 9
M3  - Article
SP  - 10
EP  - 20
PB  - Bulletin of the Atomic Scientists
SN  - 00963402
N1  - Accession Number: 21596282; Prescott, James W. 1; Affiliation:  1: Health Scientist Administrator, National institute of Child Health and Human Development, Bethesda, Maryland; Source Info: Nov1975, Vol. 31 Issue 9, p10; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Silverman, N. A.
AU  - Potvin, C.
AU  - Alexander, Jr., J. C.
AU  - Chretien, P. B.
T1  - <em>IN VITRO</em> LYMPHOCYTE REACTIVITY AND T-CELL LEVELS IN CHRONIC CIGARETTE SMOKERS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1975/11//
VL  - 22
IS  - 2
M3  - Article
SP  - 285
EP  - 292
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Peripheral blood total leucocyte, lymphocyte and thymus-dependent lymphocyte (T cell) levels and in vitro lymphocyte reactivity (LR) to phytohaemagglutinin (PHA) were determined in 153 chronic cigarette smokers and 115 non-smokers ranging in age front 20 to 78 years. Total leucocyte, lymphocyte and T-cell levels were significantly elevated in smokers. There was no correlation with age. LR to P1-IA was significantly higher in smokers less than 40 years of age or in those with a 20 pack- year or less history of cigarette consumption. Older smokers or those with a history of heavier cigarette consumption did not differ from normals. The results contrast with previous demonstrations of suppression of immune reactivity after exposure to tobacco products. The possible effects of the apparent stimulation of the lymphoid system by chronic cigarette consumption is considered. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERIPHERAL circulation
KW  - LEUCOCYTES
KW  - LYMPHOCYTES
KW  - T cells
KW  - CIGARETTE smokers
KW  - IMMUNITY
KW  - TOBACCO industry
KW  - LYMPHOID tissue
N1  - Accession Number: 15931805; Silverman, N. A. 1 Potvin, C. 1 Alexander, Jr., J. C. 1 Chretien, P. B. 1; Affiliation:  1: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Nov1975, Vol. 22 Issue 2, p285; Subject Term: PERIPHERAL circulation; Subject Term: LEUCOCYTES; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: CIGARETTE smokers; Subject Term: IMMUNITY; Subject Term: TOBACCO industry; Subject Term: LYMPHOID tissue; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Griffth, J. D.;
AU  - Nutt, J. G.;
AU  - Jasinski, D. R.;
T1  - Comparison of fenfluramine and amphetamine in man
CT  - Comparison of fenfluramine and amphetamine in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1975/11/01/
VL  - 18
IS  - Nov
SP  - 563
EP  - 570
SN  - 00099236
AD  - National Institute on Drug Abuse, Div. of Research, Addiction Research Center, P.O. Box 12390, Lexington, Kentucky 40511
N1  - Accession Number: 13-6138; Language: English; Chemical Name: Fenfluramine--458-24-2 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Anorexics dextroamphetamine, comparison, fenfluramine (28:20); AHFS Class: Anorexics fenfluramine, comparison, dextroamphetamine; References: 23; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Fenfluramine HCl (I), 60, 120 and 240 mg, dextroamphetamine (II), 20 and 40 mg, and placebo were compared in 8 postaddict volunteers, each dose given orally in random sequence at weekly intervals using a double blind crossover design. I had little effect on blood pressure and temperature, but caused a marked dilation of pupils, whereas II was a potent vasopressor and a weak mydriatic. While I produced euphoria in some subjects, its overall effects were unpleasant, sedative, and qualitatively different from II. Three subjects given 240 mg of I experienced brief but vivid hallucinogenic episodes characterized by olfactory, visual, and somatic hallucinations, abrupt polar changes in mood, time distortion, fleeting paranoia, and sexual ideation. Observations indicate that I is a hallucinogenic agent with a pharmacologic profile in man that is not amphetamine-like.
KW  - Fenfluramine--comparison, dextroamphetamine-;
KW  - Dextroamphetamine--comparison, fenfluramine-;
KW  - Dosage--fenfluramine, comparison, dextroamphetamine--effects, physiological and psychological, humans;
KW  - Dosage--dextroamphetamine, comparison, fenfluramine--effects, physiological and psychological, humans;
KW  - Anorexics--dextroamphetamine, comparison, fenfluramine--dosage, physiological and psychological effects, humans;
KW  - Anorexics--fenfluramine, comparison, dextroamphetamine--dosage, physiological and psychological effects, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Weissbach, Arthur
AU  - Baltimore, David
AU  - Bollum, Fred
AU  - Gallo, Robert
AU  - Korn, David
T1  - Nomenclature of Eukaryotic DNA Polymerases.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1975/11//Nov75 Part 1
VL  - 59
IS  - 1
M3  - Article
SP  - 1
EP  - 2
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Proposes a nomenclature of eukaryotic DNA polymerases. DNA polymerase-α; DNA polymerase-β; DNA polymerase-γ; Mitochondrial DNA polymerase.
KW  - DNA polymerases
KW  - MITOCHONDRIAL DNA
KW  - EUKARYOTIC cells
KW  - NAMES
KW  - GREEK letters
KW  - VIRUS diseases
N1  - Accession Number: 15806384; Weissbach, Arthur 1 Baltimore, David 2 Bollum, Fred 3 Gallo, Robert 4 Korn, David 5; Affiliation:  1: Department of Cell Biology, Roche Institute of Molecular Biology, 340 Kingsland Road, Nutley, New Jersey, U.S.A. 07110  2: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, U.S.A. 02139  3: Department of Biochemistry, University of Kentucky Medical Center, Lexington, Kentucky, U.S.A. 40506  4: National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, U.S.A. 20014  5: Department of Pathology, Stanford University School of Medicine, Stanford, California, U.S.A. 94305; Source Info: Nov75 Part 1, Vol. 59 Issue 1, p1; Subject Term: DNA polymerases; Subject Term: MITOCHONDRIAL DNA; Subject Term: EUKARYOTIC cells; Subject Term: NAMES; Subject Term: GREEK letters; Subject Term: VIRUS diseases; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weissbach, Arthur
AU  - Baltimore, David
AU  - Bollum, Fred
AU  - Gallo, Robert
AU  - Korn, David
T1  - Nomenclature of Eukaryotic DNA Polymerases.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1975/11//Nov75 Part 1
VL  - 59
IS  - 1
M3  - Article
SP  - 1
EP  - 2
SN  - 00142956
AB  - Proposes a nomenclature of eukaryotic DNA polymerases. DNA polymerase-α; DNA polymerase-β; DNA polymerase-γ; Mitochondrial DNA polymerase.
KW  - DNA polymerases
KW  - MITOCHONDRIAL DNA
KW  - EUKARYOTIC cells
KW  - NAMES
KW  - GREEK letters
KW  - VIRUS diseases
N1  - Accession Number: 15806384; Weissbach, Arthur 1; Baltimore, David 2; Bollum, Fred 3; Gallo, Robert 4; Korn, David 5; Source Information: Nov75 Part 1, Vol. 59 Issue 1, p1; Subject: DNA polymerases; Subject: MITOCHONDRIAL DNA; Subject: EUKARYOTIC cells; Subject: NAMES; Subject: GREEK letters; Subject: VIRUS diseases; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Neugarten, Bernice L.
T1  - Expanded options for meeting the differing needs of the young-old and the old-old.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1975/11//
VL  - 30
IS  - 11
M3  - Interview
SP  - 41
EP  - 52
SN  - 0016867X
N1  - Accession Number: 18239341; Neugarten, Bernice L. 1,2; Source Information: Nov1975, Vol. 30 Issue 11, p41; Number of Pages: 4p; Document Type: Interview; Full Text Word Count: 1906
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bigelow, L. B.;
AU  - Gillin, J. C.;
AU  - Semal, C.;
AU  - Wyatt, R. J.;
T1  - Thyrotropin releasing hormone in chronic schizophrenia
CT  - Thyrotropin releasing hormone in chronic schizophrenia
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1975/11/01/
VL  - 2
IS  - Nov 1
SP  - 869
EP  - 870
SN  - 00237507
AD  - Lab. of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Wm. A. White Building, Washington, D.C. 20032
N1  - Accession Number: 13-2237; Language: English; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents thyrotropin releasing hormone; References: 10; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2  - No beneficial effects were observed when thyrotropin releasing hormone (600 mcg for 5 days) was administered to 3 treatment-resistant schizophrenic males.
KW  - Thyrotropin releasing hormone--schizophrenia-;
KW  - Psychotherapeutic agents--thyrotropin releasing hormone--schizophrenia, lack effect, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Buchsbaum, Monte
AU  - Giwn, J. Christian
AU  - Pfefferbaum, Adolf
T1  - Effect of Sleep Stage and Stimulus Intensity on Auditory Average Evoked Responses.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1975/11//
VL  - 12
IS  - 6
M3  - Article
SP  - 707
EP  - 712
SN  - 00485772
AB  - Auditory average evoked responses (AERs) to clicks ranging from SO to 80 dB were studied in 9 normal adults while awake and during sleep. AER amplitude tended to increase little from 50 to 80 dB in waking subjects but increased markedly in sleeping subjects during stages 3 and 4. Rapid eye movement (REM) and stage 1 sleep had small amplitude AERs in comparison with other sleep stages. Individuals who showed decreases in amplitude at high intensities while awake slept significantly longer during the experimental nights. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUDITORY evoked response
KW  - SLEEP -- Stages
KW  - AUDITORY perception
KW  - SLEEP -- Physiological aspects
KW  - STIMULUS intensity
KW  - RAPID eye movement sleep
KW  - Auditory evoked responses
KW  - Reducing
KW  - REM sleep.
KW  - Sleep stage
KW  - Stimulus intensity
N1  - Accession Number: 11728788; Buchsbaum, Monte 1 Giwn, J. Christian 1 Pfefferbaum, Adolf 1; Affiliation:  1: Adult Psychiatry Branch and Laboratory of Clinical Psychopharmacology. National Institute  of Mental Health, Bethesda.; Source Info: Nov1975, Vol. 12 Issue 6, p707; Subject Term: AUDITORY evoked response; Subject Term: SLEEP -- Stages; Subject Term: AUDITORY perception; Subject Term: SLEEP -- Physiological aspects; Subject Term: STIMULUS intensity; Subject Term: RAPID eye movement sleep; Author-Supplied Keyword: Auditory evoked responses; Author-Supplied Keyword: Reducing; Author-Supplied Keyword: REM sleep.; Author-Supplied Keyword: Sleep stage; Author-Supplied Keyword: Stimulus intensity; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1469-8986.ep11728788
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Groves, Philip M.
AU  - Wilson, Charles J.
AU  - Young, Stephen J.
AU  - Rebec, George V.
T1  - Self-Inhibition by Dopaminergic Neurons.
JO  - Science
JF  - Science
Y1  - 1975/11/07/
VL  - 190
IS  - 4214
M3  - Article
SP  - 522
EP  - 529
SN  - 00368075
N1  - Accession Number: 88002802; Groves, Philip M. 1; Wilson, Charles J. 2; Young, Stephen J. 3; Rebec, George V. 4; Affiliations: 1: Professor of psychology, biopsychology area of the Department of Psychology, University of Colorado, Boulder 80302; 2: A faculty research associate, University of Colorado; 3: Graduate student in biopsychology, University of Colorado; 4: National Institute of Mental Health postdoctoral fellow, Department of Psychiatry, University of California, San Diego Medical School, La Jolla 92037; Issue Info: 11/ 7/1975, Vol. 190 Issue 4214, p522; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BENVENISTE, RAOUL E.
AU  - SHERR, CHARLES J.
AU  - TODARO, GEORGE J.
T1  - Evolution of Type C Viral Genes: Origin of Feline Leukemia Virus.
JO  - Science
JF  - Science
Y1  - 1975/11/28/
VL  - 190
IS  - 4217
M3  - Article
SP  - 886
EP  - 888
SN  - 00368075
AB  - Reiterated gene sequences related to the RNA of feline leukemia virus (FeL V) are detected in all tissues of domestic cats and their close Felis relatives but not in more distantlv related Felis species. Partiallv homologous viral gene sequences are found in rodent, and particularlv rat, DNA. Together with the immunologic relationships observed between FeL V and endogenous rodent type C viruses, the results lead to the conclusion that FeL V-related genes were transmitted from a rodent to cat ancestor and have been perpetuated in the germ line of cats. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002870; BENVENISTE, RAOUL E. 1; SHERR, CHARLES J. 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/28/1975, Vol. 190 Issue 4217, p886; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SHEARER, GENE M.
AU  - CUDKOWICZ, GUSTAVO
T1  - Induction of F1 Hybrid Antiparent Cytotoxic Effector Cells: An in vitro Model for Hemopoietic Histoincompatibility.
JO  - Science
JF  - Science
Y1  - 1975/11/28/
VL  - 190
IS  - 4217
M3  - Article
SP  - 890
EP  - 893
SN  - 00368075
AB  - An in vitro system has been developed in which F1 spleen cells can generate cytotoxic activity directed specifically against parental cells. The antigenic differences detected are controlled by the H-2D-Hh-1 region of the murine major histocompatibility complex. The parent-F1 combinations demonstrating F1 antiparent activity in vitro are the same as those demonstrating F1 rejection of parental hemopoietic grafts in vivo. Hence, the F1 antiparent cytotoxicity test serves as an in vitro model for the recognition and effector phases of hybrid resistance to parental hemopoietic grafts and may be of value in clinical transplantation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002872; SHEARER, GENE M. 1; CUDKOWICZ, GUSTAVO 2; Affiliations: 1: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Department of Pathology, School of Medicine, State University of New York, Buffalo 14214; Issue Info: 11/28/1975, Vol. 190 Issue 4217, p890; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LEDER, AYA
AU  - ORKIN, STUART
AU  - LEDER, PHILIP
T1  - Differentiation of Erythroleukemic Cells in the Presence of Inhibitors of DNA Synthesis.
JO  - Science
JF  - Science
Y1  - 1975/11/28/
VL  - 190
IS  - 4217
M3  - Article
SP  - 893
EP  - 894
SN  - 00368075
AB  - Erythroid differentiation can be readily induced by butyric acid in cultured erythroleukemic cells in the presence of inhibitors of DNA synthesis and in the absence of cell division. This result appears to rule out more complex models for globin gene expression which require gene replication or cell division (or both). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002873; LEDER, AYA 1,2; ORKIN, STUART 1,2; LEDER, PHILIP 1,2; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; 2: Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem, Israel; Issue Info: 11/28/1975, Vol. 190 Issue 4217, p893; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jaffe, R. M.;
AU  - Kasten, B.;
AU  - Young, D. S.;
AU  - MacLowry, J. D.;
T1  - False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C)
CT  - False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C)
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1975/12/01/
VL  - 83
IS  - Dec
SP  - 824
EP  - 826
SN  - 00034819
AD  - Building 10, Room 4-N-309, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 13-2870; Language: English; Trade Name: Vitamin C; Generic Name: Ascorbic acid; Chemical Name: Ascorbic acid--50-81-7; References: 13; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Karl H. Riotte
N2  - A case study and subsequent in vitro investigation involving the effect of oral ascorbic acid (I) on occult blood tests of stool is presented. A female patient with unexplained anemia who was taking 2 g/day consistently produced false negative stools for occult blood. When I was stopped, her stools became strongly reactive, and later returned to false-negative upon rechallenge. In vitro studies confirmed these findings. It was recommended that patients be taken off all I for 48 to 72 hr before tests of occult blood are done.
KW  - Ascorbic acid--effects-;
KW  - Drug interactions--ascorbic acid and tests, laboratory--effects, false negatives, occult blood tests, in anemic patient;
KW  - Drug interactions--tests, laboratory and ascorbic acid--effects, false negatives, occult blood tests, in anemic patient;
KW  - Tests, laboratory--interactions--ascorbic acid, false negative occult blood tests, in anemic patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mohr, S. J.;
AU  - Chirigos, M. A.;
AU  - Fuhrman, F. S.;
AU  - Pryor, J. W.;
T1  - Pyran copolymer as an effective adjuvant to chemotherapy against a murine leukemia and solid tumor
CT  - Pyran copolymer as an effective adjuvant to chemotherapy against a murine leukemia and solid tumor
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1975/12/01/
VL  - 35
IS  - Dec
SP  - 3750
EP  - 3754
SN  - 00085472
AD  - Viral Biology Branch, National Cancer Institute, NIH Bethesda, Maryland 20014
N1  - Accession Number: 13-2640; Language: English; Trade Name: Divinyl ether-maleic anhydride copolymer; Generic Name: NSC-46015; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents NSC-46015; References: 20; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing
N2  - Pyran (divinyl ether-maleic anhydride) copolymer (NSC-46015; I) is a polyanion with interferon-inducing and macrophage-stimulating properties, and therefore it has been studied as a possible antitumor agent. Extensive studies using pyran as an adjuvant to chemotherapy against the LSTRA murine leukemia and the Lewis lung carcinoma were performed. I was effective over a dose range of 0.1 to 100 mg/kg/day. Single and multiple dose schedules were both capable of producing significant numbers of cures or increasing life span, but pyran was ineffective if used without remission inducing chemotherapy. Various molecular weights of pyran copolymer were compared against I for adjuvant activity as well. In general, I tended to be the most efficacious, but all the pyran copolymers that were tested possessed significant activity.
KW  - NSC-46015--leukemias-;
KW  - Antineoplastic agents--NSC-46015--leukemias, therapy, in mice;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Achenbach, Thomas M.
AU  - Weisz, John R.
T1  - A Longitudinal Study of Developmental Synchrony between Conceptual Indentity, Seriation, and Transitivity of Color, Number, and Length.
JO  - Child Development
JF  - Child Development
Y1  - 1975/12//
VL  - 46
IS  - 4
M3  - Article
SP  - 840
EP  - 848
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12242817; Achenbach, Thomas M. 1 Weisz, John R. 2; Affiliation:  1: National Institute of Mental Health.  2: Cornell University.; Source Info: Dec1975, Vol. 46 Issue 4, p840; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1467-8624.ep12242817
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gatlin, L. A.;
AU  - Grimes, G. J.;
AU  - Hiranaka, P. K.;
AU  - Gallelli, J. F.;
T1  - Investigational drug information
CT  - Investigational drug information
JO  - Drug Intell. Clin. Pharm.
JF  - Drug Intell. Clin. Pharm.
Y1  - 1975/12/01/
VL  - 9
IS  - Dec
SP  - 655
EP  - 656
AD  - Pharmacy Dept., Clinical Center, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 13-5130; Language: English; Trade Name: Pyrexal--SA-1064--Threodops; Generic Name: Lipexal; Lipexal; Threo-dihydroxyphenylserine; Journal Coden: DICPBB; Section Heading: Investigational Drugs; Pharmacology; Abstract Author: D. R. Tousignaut
N2  - The stability, administration and dose, use, mechanism of action, toxicology, and route of administration of D-\a/-tocopheryl polyethylene glycol 1000 succinate (D-1-T,TPGS); threo-dihydroxyphenylserine (threo-dops), and lipexal (Pyrexal, preparations SA 1064) are given in monograph form.
KW  - D-\a/-Tocopheryl polyethylene glycol 1000 succinate--drugs, investigational-;
KW  - Threo-dihydroxyphenylserine--drugs, investigational-;
KW  - Lipexal--drugs, investigational-;
KW  - Drugs, investigational--D-\a/-tocopheryl polyethylene glycol 1000 succinate--monographs;
KW  - Drugs, investigational--threo-dihydroxyphenylserine--monographs;
KW  - Drugs, investigational--lipexal--monographs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kamisaka, Kazuaki
AU  - Habig, William H.
AU  - Ketley, Jeanne N.
AU  - Arias, Irwin M.
AU  - Jakoby, William B.
T1  - Multiple Forms of Human Glutathione S-Transferase and Their Affinity for Bilirubin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1975/12//Dec75 Part 1
VL  - 60
IS  - 1
M3  - Article
SP  - 153
EP  - 161
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The initial enzymic step in mercapturic acid formation is catalyzed by glutathione S-transferase. Several species of this enzyme, designated as transferases α, β, γ, δ and ε on the basis of increasing isoelectric points, were isolated from human liver. Evidence is presented that each of the purified species is homogeneous with respect to sodium dodeceylsulfate-gel elextrophoresis. Transferases α, β and ε each appear as a single band on gel electrofocusing; transferases &gamm; and δ are present as two and three bands, respectively, with each band catalytically active. Amino acid analysis indicated the five transferases to be either very closely related or identical in this respect. All enzyme species have a molecular weight of 48 500 and consists of two apparently identical subunits. The spectrum of substrates is the same for each although the enzymes differ slightly in specific activity. As is the case for the rat liver enzymes, each of the human transferases binds bilirubin although this compound is not a substrate. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUTATHIONE transferase
KW  - BILIRUBIN
KW  - LIVER
KW  - AMINO acids
KW  - MOLECULAR weights
KW  - GEL electrophoresis
N1  - Accession Number: 13482982; Kamisaka, Kazuaki 1 Habig, William H. 1 Ketley, Jeanne N. 1 Arias, Irwin M. 1 Jakoby, William B. 1; Affiliation:  1: Section on Enzymes and Cellular Biochemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, and The Liver Research Center, Division of Gastroenterology-Liver-Disease, Department of Medicine, Albert Einstein College of Medicine, The Bronx, New York; Source Info: Dec75 Part 1, Vol. 60 Issue 1, p153; Subject Term: GLUTATHIONE transferase; Subject Term: BILIRUBIN; Subject Term: LIVER; Subject Term: AMINO acids; Subject Term: MOLECULAR weights; Subject Term: GEL electrophoresis; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Poplack, D. G.;
AU  - Jacobs, S. A.;
T1  - Candida arthritis treated with amphotericin B
CT  - Candida arthritis treated with amphotericin B
JO  - Journal of Pediatrics (USA)
JF  - Journal of Pediatrics (USA)
Y1  - 1975/12/01/
VL  - 87
IS  - Dec
SP  - 989
EP  - 990
SN  - 00223476
AD  - Pediatric Oncology Branch, National Cancer Institute, NIH Bldg. 10 Rm 3B02 Bethesda, Maryland 20014
N1  - Accession Number: 13-3383; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 11; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Bette Bennett
N2  - A case report of an 11-yr-old girl with acute lymphoblastic leukemia who was treated with IV and intra-articular amphotericin B (I) for arthritis of the knee caused by Candida tropicalis is presented. Systemic therapy with I was given on 2 separate occasions, cumulative doses over 7 week periods of 480 mg and 525 mg, respectively and at a 3.5 month interval. Intra-articular injections of I at doses of one, 5 and 3 mg, respectively were then administered at 14 day intervals while systemic therapy with I was continued for 7 additional weeks to a total dose of 1.535 g. Systemic therapy with I apparently suppressed but did not eliminate the infection. Resolution of the arthritis occurred only after 3 intra-articular injections. Intra-articular administration of I may be a useful adjunct to systemic therapy in the treatment of candida arthritis.
KW  - Amphotericin B--arthritis-;
KW  - Arthritis--amphotericin B--Candida tropicalis, IV, comparison, intra-articular, case report;
KW  - Drug administration--routes--amphotericin B, Candida tropicalis arthritis, IV, comparison, intra-articular, case report;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Tarone, Robert E.
AU  - Gruenhage, Gary
T1  - A Note on the Uniqueness of Roots of the Likelihood Equations for Vector-Valued Parameters.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1975/12//
VL  - 70
IS  - 352
M3  - Article
SP  - 903
SN  - 01621459
AB  - Two examples are given from the literature in which results concerning functions of a single variable are applied incorrectly to multivariate functions, One of the examples concerns the proof of a basic theorem in the theory of maximum likelihood estimation of vector-valued parameters. An alternate statement and proof of the theorem are given. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANALYSIS of variance
KW  - ESTIMATION theory
KW  - MULTIVARIATE analysis
KW  - PROBABILITY theory
KW  - MATHEMATICAL statistics
KW  - VECTOR valued functions
KW  - VECTOR-valued measures
KW  - EXPERIMENTAL design
N1  - Accession Number: 4606786; Tarone, Robert E. 1; Gruenhage, Gary 2; Affiliations: 1: Research mathematical statistician, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; 2: Instructor, Mathematics Department, Auburn Univesity, Auburn, Ala. 36830.; Issue Info: Dec75, Vol. 70 Issue 352, p903; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICAL statistics; Subject Term: VECTOR valued functions; Subject Term: VECTOR-valued measures; Subject Term: EXPERIMENTAL design; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Crump, Kenny
T1  - A First Course in Probability and Statistics (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1975/12//
VL  - 70
IS  - 352
M3  - Book Review
SP  - 964
SN  - 01621459
AB  - Reviews the book "A First Course in Probability and Statistics," by Henrik J. Malik and Kenneth Mullen.
KW  - STATISTICS
KW  - PROBABILITY theory
KW  - NONFICTION
KW  - MALIK, Henrik J.
KW  - MULLEN, Kenneth
KW  - FIRST Course in Probability & Statistics, A (Book)
N1  - Accession Number: 4607066; Crump, Kenny 1; Affiliations: 1: National Institute of Environmental Health Sciences.; Issue Info: Dec75, Vol. 70 Issue 352, p964; Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: NONFICTION; Reviews & Products: FIRST Course in Probability & Statistics, A (Book); People: MALIK, Henrik J.; People: MULLEN, Kenneth; Number of Pages: 1/4p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carter, S. K.;
T1  - Adriamycin\M/a review
CT  - Adriamycin\M/a review
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1975/12/01/
VL  - 55
IS  - Dec
SP  - 1265
EP  - 1274
SN  - 00278874
AD  - Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-3491; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; References: 104; Publication Type: Review; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - An historical review of cancer chemotherapy and the place of Adriamycin (doxorubicin) in current therapeutic approaches is presented.
KW  - Doxorubicin--cancer-;
KW  - Antineoplastic agents--history--cancer, therapy, review;
KW  - History--antineoplastic agents--cancer, therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Krasnegor, N. A.;
T1  - Introduction: behavioral factors in human drug abuse
CT  - Introduction: behavioral factors in human drug abuse
JO  - Pharmacol. Rev.
JF  - Pharmacol. Rev.
Y1  - 1975/12/01/
VL  - 27
IS  - Dec
SP  - 499
EP  - 502
AD  - National Institute on Drug Abuse, Rockville, Maryland
N1  - Accession Number: 14-0907; Language: English; References: 14; Journal Coden: PAREAQ; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: Ronald E. Nagata, Jr.
N2  - An introductory presentation to a series of papers on behavioral factors in human drug abuse is presented, with emphasis on new approaches and future trends in this area of research.
KW  - Drug abuse--research--history, and future trends;
KW  - History--drug abuse--research, and future trends;
KW  - Sociology--drug abuse--research, history and future trends;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Tower, D. B.;
T1  - What you should know about the epilepsies
CT  - What you should know about the epilepsies
JO  - Pharmacy Times (USA)
JF  - Pharmacy Times (USA)
Y1  - 1975/12/01/
VL  - 41
IS  - Dec
SP  - 44
EP  - 51
SN  - 00030627
AD  - National Institute of Neurological & Communicative Disorders & Stroke, National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 13-3237; Language: English; Journal Coden: PYTMAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Walter F. Stanaszek
N2  - A discussion of the incidence, etiology, current research, prognosis, and medication and surgical treatment of the various forms of epilepsy is presented.
KW  - Anticonvulsants--epilepsy--therapy, etiology and prognosis, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06269-079
AN  - 2006-06269-079
AU  - Wender, Paul H.
AU  - Rosenthal, David
AU  - Kety, Seymour S.
T1  - Distorted picture.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1975/12//
VL  - 20
IS  - 12
SP  - 986
EP  - 987
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06269-079. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wender, Paul H.; University of Utah, Salt Lake City, UT, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Schizophrenia; Treatment. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 2. Issue Publication Date: Dec, 1975. 
AB  - Comments on Bertram Karon's review (see record [rid]2006-06272-008[/rid]) of Theodore Lidz's book The Origin and Treatment of Schizophrenic Disorders (1973). The present authors maintain that Karon's review presents an extremely distorted picture of current understanding of the causes of schizophrenic disorders, and is, to readers unaware of recent progress in the field, grossly misleading. The following points in the review are clarified: Karon reviews Lidz's assertions that schizophrenia is produced by exposure to deviant families in childhood and adolescence. This is a familiar position that has been advanced by a number of authors antedating as well as following Lidz. Karon restates Lidz's position and quotes him as saying 'how unconvincing the widely heralded supposed evidence for genetic factors really are.' In support of this position, he mentions the fact that in one adoption study of schizophrenics, adopted parents were found to have Rorschachs indistinguishable from those of the biological parents of schizophrenics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenic disorders
KW  - schizophrenia
KW  - causes
KW  - 1975
KW  - Schizophrenia
KW  - Treatment
KW  - 1975
DO  - 10.1037/014528
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - BUZNEY, SHELDON M.
AU  - FRANK, ROBERT N.
AU  - ROBISON, W. GERALD
T1  - Retinal Capillaries: Proliferation of Mural Cells in vitro.
JO  - Science
JF  - Science
Y1  - 1975/12/05/
VL  - 190
IS  - 4218
M3  - Article
SP  - 985
EP  - 986
SN  - 00368075
AB  - Capillaries from bovine, monkey, and human retinas maintained in tissue culture produced a monolayer of cells. A utoradiographic and electron microscopic evidence indicated that the mural cells (intramuralpericytes) were the c ells that proliferated. Since intramural pericytes are damaged selectively in diabetes mellitus, their availability in culture will be usejul in seeking means to control diabetic retinopathy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002888; BUZNEY, SHELDON M. 1; FRANK, ROBERT N. 1; ROBISON, W. GERALD 2; Affiliations: 1: Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Vision Research, National Eye Institute; Issue Info: 12/ 5/1975, Vol. 190 Issue 4218, p985; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - McLACHLAN, J. A.
AU  - NEWBOLD, R. R.
AU  - BULLOCK, B.
T1  - Reproductive Tract Lesions in Male Mice Exposed Prenatally to Diethylstilbestrol.
JO  - Science
JF  - Science
Y1  - 1975/12/05/
VL  - 190
IS  - 4218
M3  - Article
SP  - 991
EP  - 992
SN  - 00368075
AB  - Sixyty percent of the male off spring from pregnant mice treated with diethylistilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal orfibrotic testes, or both. Additionally, nodular masses in the ampullarv region of the reproductive tract were observed in 6 of 24 animals: one of these appeared to be preneoplastic. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002891; McLACHLAN, J. A. 1; NEWBOLD, R. R. 1; BULLOCK, B. 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Bowman-Gray School of Medicine, Winston-Salem, North Carolina 27103; Issue Info: 12/ 5/1975, Vol. 190 Issue 4218, p991; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GREEN, JON A.
AU  - BARON, SAMUEL
T1  - 5-lododeoxyuridine Potentiation of the Replication In Vitro of Several Unrelated RNA and DNA Viruses.
JO  - Science
JF  - Science
Y1  - 1975/12/12/
VL  - 190
IS  - 4219
M3  - Article
SP  - 1099
EP  - 1101
SN  - 00368075
AB  - Enhancement of the replication of unrelated viruses (three RNA viruses and one DNA virus), representative of four major virus groups, occurs in human, rodent, or avian cells treated in vitro with 5-iododeoxyuridine (IdU). The results suggest that the potentiation of viral replication by IdU is a widespread phenomenon. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002909; GREEN, JON A. 1; BARON, SAMUEL 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 12/12/1975, Vol. 190 Issue 4219, p1099; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Zunino, Franco
AU  - Gambetta, Romolo
AU  - Colombo, Ambrogio
AU  - Luoni, Giuseppe
AU  - Zaccara, Adriano
T1  - DNA Polymerases of Rat Liver.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1975/12/15/Dec75 Part 2
VL  - 60
IS  - 2
M3  - Article
SP  - 495
EP  - 504
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Three distinct DNA-dependent DNA polymerase activities have been partially purified from normal rat liver. Soluble activities are separable into two distinct fractions (P1 and P2) by phosphocellulose chromatography. A low-molecular-weight DNA polymerase was isolated from purified nuclei. The enzymes were characterized according to chromatographic and sedimentation behavior, enzymological properties, and response to various inhibitors. The results indicate that fraction P1 corresponds to the high-molecular-weight enzyme and suggest that polymerase P2 may be derived from partial dissociation of the high-molecular-weight enzyme. The molecular weight of polymerase Pi was estimated to be about 250 000 by Sephadex column chromatography. Both fraction P2 and nuclear DNA polymerase appeared to be low-molecular-weight enzymes. However, the molecular size of these activities was apparently different. The estimated molecular weights of nuclear and P2 enzyme are about 40 000 and 25 000, respectively. As with the nuclear enzyme, polymerase P2 (but not P1) appeared to be free of detectable exonuclease activity. All of these polymerases showed a marked preference for initiated polydeoxyribonucleotide templates. The rat liver polymerases differed in their ability to use poly[d(A-T)] primer-template, as is shown by the ratios of their activity with this synthetic polymer to that with activated DNA: 0.5, 2.75, and 1.34 for P1, P2, and nuclear polymerase, respectively. Denatured DNA was a poor template for both enzymes P1 and P2, but it was inert as template for the nuclear enzyme. Although each of these polymerases required all four deoxynucleoside triphosphates for maximal activity, they catalyzed a high rate of synthesis in the absence of one or more deoxynucleoside triphosphates. Such a 'limited' synthesis was much more extensive for polymerase P2 and nuclear enzyme than for P1. Polymerase P1 was the most sensitive of the three to sulphydryl reagents, ethidium bromide, heparin, and single-stranded DNA. The responses of P2 and nuclear enzymes to various inhibitors were very similar. However, these two enzymes respond differently to heat and high ionic strength. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA polymerases
KW  - ENZYMES
KW  - NUCLEIC acids
KW  - CATALYSTS
KW  - CHROMATOGRAPHIC analysis
KW  - CRYOSCOPY
N1  - Accession Number: 13483013; Zunino, Franco 1 Gambetta, Romolo 1 Colombo, Ambrogio 1 Luoni, Giuseppe 1 Zaccara, Adriano 1; Affiliation:  1: Division of Experimental Oncology B, National Cancer Institute, Milano; Source Info: Dec75 Part 2, Vol. 60 Issue 2, p495; Subject Term: DNA polymerases; Subject Term: ENZYMES; Subject Term: NUCLEIC acids; Subject Term: CATALYSTS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CRYOSCOPY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MILLER, Z.
AU  - LOVELACE, E.
AU  - GALLO, M.
AU  - PASTAN, I.
T1  - Cyclic Guanosine Monophosphate and Cellular Growth.
JO  - Science
JF  - Science
Y1  - 1975/12/19/
VL  - 190
IS  - 4220
M3  - Article
SP  - 1213
EP  - 1215
SN  - 00368075
AB  - The addition of serum to nongrowing cells decreases cyclic guanosine monophosphate and cyclic adenosine monophosphate levels and promotes cell growth. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88002935; MILLER, Z. 1; LOVELACE, E. 1; GALLO, M. 1; PASTAN, I. 1; Affiliations: 1: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/19/1975, Vol. 190 Issue 4220, p1213; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - CHAP
ID  - 2004-16189-020
AN  - 2004-16189-020
AU  - Thompson, Vaida D.
AU  - Newman, Sidney H.
ED  - Woods, Paul J.
ED  - Woods, Paul J., (Ed)
T1  - Training and research opportunities in population psychology.
T2  - Career opportunities for psychologists.
Y1  - 1976///
SP  - 232
EP  - 248
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 0-912704-03-9
N1  - Accession Number: 2004-16189-020. Partial author list: First Author & Affiliation: Thompson, Vaida D.; University of North Carolina at Chapel Hill, Department of Psychology, Chapel Hill, NC, US. Release Date: 20040809. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-03-9, Paperback. Language: English. Major Descriptor: Population; Professional Specialization; Psychologists. Minor Descriptor: Experimentation; History; Postgraduate Training; Behavioral Ecology. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 17. 
AB  - The goal of this chapter is to convey to young psychologists--and to those planning to become psychologists--the need for research that will contribute more fully to an understanding of population and population-related behaviors, which pertain to some of the most important problems in the world. In addition, we delineate ways in which interested students and psychologists can educate and develop themselves for working in the population field, still a relatively new field for psychologists. The most advantageous first step in becoming a population psychologist is to find a mentor whose own research interests are in population. There is an ever-increasing number of such persons, and their counsel may be sought. Even a student currently being trained with no focus on population issues or related research can learn about the issues, can ultimately focus on these issues in research, and can possibly find postdoctoral training and research support to further these goals. This chapter is thus directed toward three major topics: What are the areas and issues of research in population psychology? How can psychology trainees prepare themselves for work in this area? What postdoctoral training and research support opportunities may assist them toward their goals? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychologists
KW  - population psychology
KW  - professional specialization
KW  - behavioral ecology
KW  - research
KW  - postdoctoral training
KW  - history
KW  - 1976
KW  - Population
KW  - Professional Specialization
KW  - Psychologists
KW  - Experimentation
KW  - History
KW  - Postgraduate Training
KW  - Behavioral Ecology
KW  - 1976
DO  - 10.1037/10526-020
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Dietz, W. H.
AU  - Porcell, O.
AU  - Moon, T. E.
AU  - Peters, C. J.
AU  - Purcell, R. H.
T1  - IgM levels and IgM-mediated immune responses in patients with acute hepatitis A, acute hepatitis b and chronic HB antigenaemia.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/01//
VL  - 23
IS  - 1
M3  - Article
SP  - 69
EP  - 72
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A. acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed in both types of acute hepatitis, but not in chronic hepatitis B antigenaemia. There was no correlation of the IgM level with either the prevalence or titre of any IgM-mediated immune response studied. These data suggest that the IgM elevations in both types of hepatitis may reflect virus-specific IgM synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN M
KW  - IMMUNE response
KW  - IMMUNOLOGY
KW  - AGGLUTININS
KW  - HEPATITIS B
KW  - LIVER diseases
KW  - RHEUMATOID arthritis
N1  - Accession Number: 15985071; Dietz, W. H. 1 Porcell, O. 1 Moon, T. E. 1 Peters, C. J. 1 Purcell, R. H. 2; Affiliation:  1: Gorgas Memorial Institute--Middle America  2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland U.S.A.; Source Info: Jan1976, Vol. 23 Issue 1, p69; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: AGGLUTININS; Subject Term: HEPATITIS B; Subject Term: LIVER diseases; Subject Term: RHEUMATOID arthritis; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kleinman, L. M.;
AU  - Davignon, J. P.;
AU  - Cradock, J. C.;
AU  - Penta, J. S.;
AU  - Slavik, M.;
T1  - Investigational drug information
CT  - Investigational drug information
JO  - Drug Intell. Clin. Pharm.
JF  - Drug Intell. Clin. Pharm.
Y1  - 1976/01/01/
VL  - 10
IS  - Jan
SP  - 48
EP  - 49
AD  - Cancer Therapy Evaluation Program, Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-5252; Language: English; Trade Name: NSC-13875--NSC-45388--NSC-409962--Imidazole carboxamide--Dimethyltriazeno imidazole carboxamide; Generic Name: Hexamethylmelamine; Dacarbazine; Carmustine; Dacarbazine; Dacarbazine; Chemical Name: Dacarbazine--4342-03-4 Carmustine--154-93-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents hexamethylmelamine (10:00); AHFS Class: Antineoplastic agents dacarbazine (10:00); AHFS Class: Antineoplastic agents carmustine; References: 12; Journal Coden: DICPBB; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: D. R. Tousignaut
N2  - Monographs on hexamethylmelamine (HXM, NSC-13875, HMM), dacarbazine (DTIC, DIC, imidazole carboxamide, NSC-45388, dimethyltriazeno imidazole carboxamide) and carmustine (BCNU, NSC-409962) including description, storage pharmacology and mechanism of action, structure, preparation, route of administration, suggested dose, and use or purpose of investigation are presented.
KW  - Hexamethylmelamine--monographs-;
KW  - Dacarbazine--monographs-;
KW  - Carmustine--monographs-;
KW  - Antineoplastic agents--hexamethylmelamine--monographs;
KW  - Antineoplastic agents--dacarbazine--monographs;
KW  - Antineoplastic agents--carmustine--monographs;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5252&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Schweitzer, Stuart O.
T1  - Unemployment in the Urban Core: An Analysis of Thirty Cities with Policy Recommendations (Book Review).
JO  - ILR Review
JF  - ILR Review
Y1  - 1976/01//
VL  - 29
IS  - 2
M3  - Book Review
SP  - 291
EP  - 293
PB  - Sage Publications Inc.
SN  - 00197939
AB  - The article reviews the book "Unemployment in the Urban Core: An Analysis of Thirty Cities with Policy Recommendations," by Stanley L. Friedlander.
KW  - UNEMPLOYMENT
KW  - NONFICTION
KW  - FRIEDLANDER, Stanley L.
KW  - UNEMPLOYMENT in the Urban Core: An Analysis of Thirty Cities With Policy Recommendations (Book)
N1  - Accession Number: 4456165; Schweitzer, Stuart O. 1; Affiliations: 1: Fogarty International Center for Advanced Studies, National Institutes of Health, Bethesda, Maryland; Issue Info: Jan76, Vol. 29 Issue 2, p291; Thesaurus Term: UNEMPLOYMENT; Subject Term: NONFICTION; Reviews & Products: UNEMPLOYMENT in the Urban Core: An Analysis of Thirty Cities With Policy Recommendations (Book); People: FRIEDLANDER, Stanley L.; Number of Pages: 3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pizzo, P. A.;
AU  - Henderson, E. S.;
AU  - Leventhal, B. G.;
T1  - Acute myelogenous leukemia in children: a preliminary report of combination chemotherapy
CT  - Acute myelogenous leukemia in children: a preliminary report of combination chemotherapy
JO  - Journal of Pediatrics (USA)
JF  - Journal of Pediatrics (USA)
Y1  - 1976/01/01/
VL  - 88
IS  - Jan
SP  - 125
EP  - 130
SN  - 00223476
AD  - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-6133; Language: English; Chemical Name: Prednisolone--50-24-8 Vincristine--57-22-7 Methotrexate--59-05-2 Mercaptopurine--6112-76-1 Cytarabine--147-94-4 Daunorubicin--20830-81-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents prednisolone (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents mercaptopurine (10:00); AHFS Class: Antineoplastic agents cytarabine (10:00); AHFS Class: Antineoplastic agents daunorubicin; References: 34; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Robert Harrison
N2  - Twenty-four randomly selected children (2 to 21 yr) with acute myelogenous leukemia were treated with single combination or alternating chemotherapy. Patients received prednisolone (I), vincristine (II), methotrexate, and mercaptopurine (POMP) or I, II, cytarabine, and daunorubicin (PRAVD) or alternating courses. Seventeen patients achieved complete remission, with those patients receiving POMP alone achieving the longest median duration of remission (1,400 days) when compared with PRAVD alone (395 days) and POMP-PRAVD combination (270 days). Fifteen of the 17 patients who had achieved remission eventually relapsed. The favorable initial response warrants further investigation of optimal maintenance schedules for treating acute myelogenous leukemia once remission has occurred.
KW  - Prednisolone--combined therapy-;
KW  - Vincristine--combined therapy-;
KW  - Methotrexate--combined therapy-;
KW  - Mercaptopurine--combined therapy-;
KW  - Cytarabine--combined therapy-;
KW  - Daunorubicin--combined therapy-;
KW  - Antineoplastic agents--prednisolone--combined therapy, acute myelogenous leukemia, in children;
KW  - Antineoplastic agents--vincristine--combined therapy, acute myelogenous leukemia, in children;
KW  - Antineoplastic agents--methotrexate--combined therapy, acute myelogenous leukemia, in children;
KW  - Antineoplastic agents--mercaptopurine--combined therapy, acute myelogenous leukemia, in children;
KW  - Antineoplastic agents--cytarabine--combined therapy, acute myelogenous leukemia, in children;
KW  - Antineoplastic agents--daunorubicin--combined therapy, acute myelogenous leukemia, in children;
KW  - Combined therapy--antineoplastic agents--leukemias, acute myelogenous, in children;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-6133&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pizzo, P. A.;
AU  - Bleyer, W. A.;
AU  - Poplack, D. G.;
AU  - Leventhal, B. G.;
T1  - Reversible dementia temporally associated with intraventricular therapy with methotrexate in a child with acute myelogenous leukemia
CT  - Reversible dementia temporally associated with intraventricular therapy with methotrexate in a child with acute myelogenous leukemia
JO  - Journal of Pediatrics (USA)
JF  - Journal of Pediatrics (USA)
Y1  - 1976/01/01/
VL  - 88
IS  - Jan
SP  - 131
EP  - 133
SN  - 00223476
AD  - Pediatric Oneology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-4498; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 19; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2  - A case report of reversible dementia in a child with acute myelogenous leukemia receiving maintenance intraventricular methotrexate (I) (12 ng/sq m) is presented. CSF levels of I were in the nontoxic range and neurological evaluation failed to demonstrate anatomical obstruction, infection, or folate depletion. The patient's symptoms gradually subsided when I was discontinued suggesting that I neurotoxicity may occur in the absence of an elevated CSF concentration of I.
KW  - Methotrexate--adverse reactions-;
KW  - Drugs, adverse reactions--methotrexate--dementia, in child;
KW  - Antineoplastic agents--methotrexate--adverse reactions, dementia, in child;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Narin, Francis
AU  - Pinski, Gabriel
AU  - Gee, Helen Hofer
T1  - Structure of the Biomedical Literature.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
Y1  - 1976/01//
VL  - 27
IS  - 1
M3  - Article
SP  - 25
EP  - 45
SN  - 00028231
AB  - The structure and interrelations of the biomedical journal literature are investigated as a preparatory step for studies of biomedical research activity. Using newly developed methods of bibliographic citation analysis, approximately 900 biomedical journals are classified into approximately 50 separate fields and into four research levels. The research-level scale indicates research orientation ranging from clinical observation to basic research. Measures of influence are then obtained for individual journals, for biomedical fields and for research levels. The fields of biochemistry and physiology are shown to have the highest citation influence. A hierarchical influence diagram is presented to display the influence of 42 fields within biomedicine. Hierarchical influence diagrams are also presented for several individual fields showing the influence structure and citation relationships among their component journals. The combination of a subject, a level and an influence measure provides a unified framework for planned research activity analysis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL literature
KW  - MEDICAL sciences
KW  - PHYSIOLOGY
KW  - PERIODICALS
KW  - BIOCHEMISTRY
KW  - MEDICAL research
N1  - Accession Number: 16755261; Narin, Francis 1; Pinski, Gabriel 1; Gee, Helen Hofer 2; Affiliations: 1: Computer Horizons, Inc. Cherry Hill, NJ 08034.; 2: Division of Program Analysis National Institutes of Health Bethesda, MD 20014.; Issue Info: Jan1976, Vol. 27 Issue 1, p25; Subject Term: MEDICAL literature; Subject Term: MEDICAL sciences; Subject Term: PHYSIOLOGY; Subject Term: PERIODICALS; Subject Term: BIOCHEMISTRY; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; Number of Pages: 21p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Beaven, M. A.;
T1  - Histamine. Parts 1 and 2
CT  - Histamine. Parts 1 and 2
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1976/01/01/
VL  - 294
IS  - Jan 1; Feb 5
SP  - 30
EP  - 25
SN  - 00284793
AD  - National Institutes of Health, Bldg. 10, Rm. 5N107, Bethesda, Maryland 20014
N1  - Accession Number: 13-3484; Language: English; Chemical Name: Histamine--51-45-6; References: 14; Journal Coden: NEJMAG; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - Part one includes a discussion on the discovery of histamine and its actions; the nature of histamine stores in tissues: mast-cell and non-mast-cell histamine; release of histamine from mast cells; and the synthesis and metabolism of histamine. The classic antihistamines (H\IF/1\BS/ inhibitors), a second type of histamine receptor (H\IF/2\BS/ receptor) and the discovery of antagonists to these receptors, the role of histamine in gastric secretion, recent findings on the mechanism of histamine release in inflammation and immediate hypersensitivity reactions, recent developments in the assay of histamine and the possible role of histamine in the central nervous system are discussed in part 2.
KW  - Histamine--pharmacology-;
KW  - Antihistamines--pharmacology--discussion;
KW  - Pharmacology--antihistamines--discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-42033-022
AN  - 2013-42033-022
AU  - Shore, Milton F.
T1  - Review of Adolescent psychiatry Volume II: Developmental and clinical studies and  Adolescent psychiatry, Volume III: Developmental and clinical studies.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1976/01//
VL  - 46
IS  - 1
SP  - 182
EP  - 183
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42033-022. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Psychiatry; Family Therapy; Government Policy Making; Psychiatric Hospitalization. Minor Descriptor: Disadvantaged. Classification: Psychological Disorders (3210); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Reviewed Item: Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). Adolescent psychiatry volume II: Developmental and clinical studies=450 pp. $15.00. Basic Books, New York; 1973. Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). Adolescent psychiatry volume III: Develomental and clinical studies=456 pp. $17.50. Basic Books, New York; 1974. Page Count: 2. Issue Publication Date: Jan, 1976. 
AB  - Reviews the books, Adolescent Psychiatry Volume II: Developmental and Clinical Studies edited by Sherman C. Feinstein and Peter L. Giovacchini (1973) and Adolescent Psychiatry Volume III: Developmental and Clinical Studies edited by Sherman C. Feinstein and Peter L. Giovacchini (1974). Included are chapters on medical settings; family therapy; the disadvantaged adolescent; psychiatric hospitalization; war and youth; delinquency and violence. The clinical articles still comprise the majority of chapters. Although they are often exciting, they sometimes appear too short or seem to resemble lectures that were transferred to print, rather than scholarly articles. The authors have posed the challenge for the future volumes of this series. From the development of this set of volumes, it appears more and more possible that the editors may rise to the challenge in the future with articles on prevention, on the mentally retarded adolescent, on the brain damaged adolescent. and on the abused adolescent, as well as more substantive articles on those economic. cultural. and social factors that must be understood if we are indeed to develop programs that can go beyond the repetition of stock phrases towards practical and sophisticated suggestions for a well planned national social policy for youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adolescent psychiatry
KW  - psychiatric hospitalization
KW  - medical settings
KW  - family therapy
KW  - disadvantaged adolescents
KW  - social policy
KW  - 1976
KW  - Adolescent Psychiatry
KW  - Family Therapy
KW  - Government Policy Making
KW  - Psychiatric Hospitalization
KW  - Disadvantaged
KW  - 1976
U2  - Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). (1973); Adolescent psychiatry volume II: Developmental and clinical studies; 450 pp. $15.00. Basic Books, New York
U2  - Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). (1974); Adolescent psychiatry volume III: Develomental and clinical studies; 456 pp. $17.50. Basic Books, New York
DO  - 10.1037/h0098744
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42033-022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-05515-005
AN  - 2009-05515-005
AU  - Kety, Seymour S.
AU  - Rosenthal, David
AU  - Wender, Paul H.
AU  - Schulsinger, Fini
T1  - Studies based on a total sample of adopted individuals and their relatives: Why they were necessary, what they demonstrated and failed to demonstrate.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1976///
VL  - 2
IS  - 3
SP  - 413
EP  - 428
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kety, Seymour S., Psychiatric Research Laboratories, Harvard Medical School, Massachusetts General Hospital, Boston, MA, US, 02114
N1  - Accession Number: 2009-05515-005. PMID: 1006193 Partial author list: First Author & Affiliation: Kety, Seymour S.; Harvard Medical School, Cambridge, MA, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Environmental Effects; Etiology; Genetics; Schizophrenia. Minor Descriptor: Adoption (Child); Family; Twins. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 16. Issue Publication Date: 1976. 
AB  - Studies of adopted individuals and their biological and adoptive families offer a means of disentangling the genetic and environmental contributions to a disorder such as schizophrenia and permit an examination of the effects of one type of influence while the other is randomized or controlled. Using this strategy in a series of studies, we have obtained results pertinent to genetic and family-interaction theories of etiology in a considerably lesser degree to the confounding of these influences that have flawed previous studies in both fields. There is every reason that these studies should be presented and criticized in an issue of the Schizophrenia Bulletin devoted to genetics, just as another strategy—high risk studies—was previously examined. This article focuses on two such cases: A view of adoption studies from the twin study vantage point—the critique by Gottesman and Shields; A view of adoption studies through the holes of a 'tightly knit theory' of parental deviance—the critique by Lidz. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adoption studies
KW  - twin studies
KW  - genetic contributions
KW  - environmental contributions
KW  - schizophrenia
KW  - 1976
KW  - Environmental Effects
KW  - Etiology
KW  - Genetics
KW  - Schizophrenia
KW  - Adoption (Child)
KW  - Family
KW  - Twins
KW  - 1976
U1  - Sponsor: National Institute of Mental Health, Intramural Research Program. Recipients: No recipient indicated
U1  - Sponsor: Scottish Rite Schizophrenia Research Program. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Mental Health. Grant: MH 15602; MH 25515. Recipients: No recipient indicated
DO  - 10.1093/schbul/2.3.413
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Appelbaum, F. R.;
AU  - Strauchen, J. A.;
AU  - Graw, R. G.;
AU  - Savage, D. D.;
AU  - Kent, D. M.;
AU  - \ET/;
T1  - Acute lethal carditis caused by high dose combination chemotherapy
CT  - Acute lethal carditis caused by high dose combination chemotherapy
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/01/10/
VL  - 1
IS  - Jan 10
SP  - 58
EP  - 62
SN  - 00237507
AD  - Bldg. 10, Rm. 3B14, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 13-3039; Language: English; Trade Name: Bis-chloroethyl nitrosurea--Cytosine arabinoside; Generic Name: Carmustine; Cytarabine; Chemical Name: Carmustine--154-93-8 Cytarabine--147-94-4 Cyclophosphamide--6055-19-2 Thioguanine--154-42-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine (10:00); AHFS Class: Antineoplastic agents cytarabine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents thioguanine; References: 18; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Investigational Drugs
N2  - An acute lethal myopericarditis was observed in 4 out of 15 patients receiving the BACT regimen consisting of bis-chloroethyl nitrosourea (carmustine), cytosine arabinoside (cytarabine), cyclophosphamide and 6-thioguanine. In all cases the myopericarditis occurred 5-9 days after the initiation of chemotherapy, with dyspnea, tachycardia, orthostatic hypotension, fluid retention, decreased voltage on electrocardiography, and pericardial effusion documented by echocardiogram, and progressed in 2 to 6 days to a fatal low output state despite vigorous treatment. In 3 of the 4 patients, necropsy was permitted and revealed the unique pathological finding of fibrin microthrombi in capillaries, fibrin strands in the interstitium, and fibrin strands within the heart muscle cells.
KW  - Carmustine--adverse reactions-;
KW  - Cytarabine--adverse reactions-;
KW  - Cyclophosphamide--adverse reactions-;
KW  - Thioguanine--adverse reactions-;
KW  - Drugs, adverse reactions--carmustine--myopericarditis, lethal, combined therapy, in patients;
KW  - Drugs, adverse reactions--cytarabine--myopericarditis, lethal, combined therapy, in patients;
KW  - Drugs, adverse reactions--cyclophosphamide--myopericarditis, lethal, combined therapy, in patients;
KW  - Drugs, adverse reactions--thioguanine--myopericarditis, lethal, combined therapy, in patients;
KW  - Combined therapy--antineoplastic agents--myopericarditis, lethal, in patients;
KW  - Antineoplastic agents--carmustine--combined therapy, lethal myopericarditis, in patients;
KW  - Antineoplastic agents--cytarabine--combined therapy, lethal myopericarditis, in patients;
KW  - Antineoplastic agents--cyclophosphamide--combined therapy, lethal myopericarditis, in patients;
KW  - Antineoplastic agents--thioguanine--combined therapy, lethal myopericarditis, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Hoff, D. D.;
AU  - Slavik, M.;
AU  - Muggia, F. M.;
T1  - Allergic reactions to cis platinum
CT  - Allergic reactions to cis platinum
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/01/10/
VL  - 1
IS  - Jan 10
SP  - 90
SN  - 00237507
AD  - Chemotherapy Evaluation Program and Investigational Drug Branch, Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-3040; Language: English; Trade Name: NSC-119875; Generic Name: cis-Diaminedichloroplatinum; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cis-diaminedichloroplatinum; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Investigational Drugs; Abstract Author: Joan Lentine
N2  - Eight cases of anaphylactic-like reactions possibly secondary to cis-diaminedichloroplatinum (NSC-119875) administration are reported. The reactions consisted of facial edema, wheezing, tachycardia, and hypotension within a few min of IV drug administration. All reactions were controlled with IV adrenaline, corticosteroids, or antihistamines. All of these patients had received prior cis-platinum and all were receiving cis-platinum with various combinations of other chemotherapeutic agents.
KW  - cis-Diaminedichloroplatinum--adverse reactions-;
KW  - Drugs, adverse reactions--cis-diaminedichloroplatinum--anaphylaxis, in patients;
KW  - Antineoplastic agents--cis-diaminedichloroplatinum--anaphylaxis, in patients;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MARTIN, JEANNE E.
AU  - KLEIN, DAVID C.
T1  - Melatonin Inhibition of the Neonatal Pituitary Response to Luteinizing Hormone-Releasing Factor.
JO  - Science
JF  - Science
Y1  - 1976/01/23/
VL  - 191
IS  - 4224
M3  - Article
SP  - 301
EP  - 302
SN  - 00368075
AB  - Neonatal rat anterior pituitary glands treated in organ culture with I nanomolar luteinizing hormone-releasing factor (LRF) showed a tenfold increase in medium luteinizing hormone (LH) concentrations over control values. Simultaneous treatment of the glands with I nanomolar melatonin significantly reduced the stimulatory effect of LRF on release of LH. This finding indicates that melatonin can act directly on the neonatal pituitary to inhibit the LH response to LRF. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85233124; MARTIN, JEANNE E. 1; KLEIN, DAVID C. 1; Affiliations: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/23/1976, Vol. 191 Issue 4224, p301; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LEVIS, WILLIAM R.
AU  - WHALEN, JOHN J.
AU  - SHERINS, RICHARD J.
T1  - Mixed Cultures of Sperm and Leukocytes as a Measure of Histocompatibility in Man.
JO  - Science
JF  - Science
Y1  - 1976/01/23/
VL  - 191
IS  - 4224
M3  - Article
SP  - 302
EP  - 304
SN  - 00368075
AB  - Human peripheral blood leukocyte cultures containing varying numbers of washedfresh sperm were cultured for 4 days. [3H] Thymidine incorporation was used as a measure of lymphocyte transformation. Human sperm cells induce a 4- to 250-fold increase in [3H]thymidine incorporation in allogeneic leukocyte cultures, but no increase was demonstrated in autologous leukocyte cultures. The response was dose-dependent with maximum stimulation obtained at 2 × 106 sperm per milliliter of culture. Seminal plasma was inhibitory in a dose-dependent fashion and as little as 0.2 microliter per 200 microliters of culture was inhibitory. The data indicate that tissues other than leukocytes can express the portion of the major histocompatibility complex responsible for allospecific lymphocyte transformation, and thus may have application in transplantation and reproductive biology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85233125; LEVIS, WILLIAM R. 1; WHALEN, JOHN J. 1; SHERINS, RICHARD J. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 1/23/1976, Vol. 191 Issue 4224, p302; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Post, R. M.;
AU  - Gerner, R. H.;
AU  - Carman, J. S.;
AU  - Bunney, W. E.;
T1  - Effects of low doses of a dopamine receptor stimulator in mania
CT  - Effects of low doses of a dopamine receptor stimulator in mania
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/01/24/
VL  - 1
IS  - Jan 24
SP  - 203
EP  - 204
SN  - 00237507
AD  - Adult Psychiatry Branch, Section of Psychobiology, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 13-3098; Language: English; Trade Name: ET-495; Generic Name: Piribedil; Chemical Name: Piribedil--3605-01-4; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents piribedil; References: 15; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2  - Results of a preliminary trial in 2 manic patients showed that low oral doses of piribedil (ET-495) (60 mg/day) may produce antimanic effects.
KW  - Piribedil--mania-;
KW  - Psychotherapeutic agents--piribedil--mania, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - LENEVEU, D. M.
AU  - RAND, R. P.
AU  - GINGELL, D.
AU  - PARSEGIAN, V. A.
T1  - Apparent Modification of Forces Between Lecithin Bilayers.
JO  - Science
JF  - Science
Y1  - 1976/01/30/
VL  - 191
IS  - 4225
M3  - Article
SP  - 399
EP  - 400
SN  - 00368075
AB  - Small sugar solutes effect variation in the equilibrium separation of lecithin bilayers in aqueous solution. Since sugars have negligible influence on bilayer structure, they probably act by modifying inrterbilayerforces. The observed widening and narrowing of the bilayer separation is correlated with the predicted weakening and strengthening of the attractive van der Waals forces between lipid bilayers that occurs with increasingsugar concentrations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219638; LENEVEU, D. M. 1; RAND, R. P. 1; GINGELL, D. 2; PARSEGIAN, V. A. 3; Affiliations: 1: Brock University, St. Catharines, Ontario, Canada L2S 3A I; 2: Middlesex Hospital Medical School, London, England WIP 7PN; 3: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/30/1976, Vol. 191 Issue 4225, p399; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ross, G. T.;
T1  - Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms
CT  - Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms
JO  - Cancer (Philadelphia)
JF  - Cancer (Philadelphia)
Y1  - 1976/02/01/
VL  - 37
IS  - Feb
SP  - 1043
EP  - 1047
AD  - Reproduction Research Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-0386; Language: English; References: 16; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Michael A. Eldon
N2  - Use of therapeutic alternatives in treatment of gestational trophoblastic neoplasms can retain reproductive potential of women even after exposure to potential teratogenic agents. Fifty-eight women who conceived following successful chemotherapy of gestational trophoblastic neoplasms subsequently became pregnant a total of 96 times. Of the 96 pregnancies, 78 terminated in liveborn infants. Fifteen ended in abortion and 3 terminated with stillborn infants. Among the liveborn and stillborn infants there were 3 with congenital malformations classified as major. While this incidence of congenital malformations does not appear to be increased over that expected, the numbers are too small to perceive a 2-fold increase in the expected incidence. Suggestions are made for improvement in the quality of these data.
KW  - Antineoplastic agents--teratogenicity--anomalies, congenital, following maternal therapy for trophoblastic neoplasms;
KW  - Teratogenicity--antineoplastic agents--anomalies, congenital, following maternal therapy for trophoblastic neoplasms;
KW  - Toxicity--antineoplastic agents--teratogenicity, congenital anomalies, following maternal therapy for trophoblastic neoplasms;
KW  - Placental transfer--antineoplastic agents--teratogenicity, congenital anomalies, following maternal therapy for trophoblastic neoplasms;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hoover, R. N.;
T1  - Bacillus Calmette-Guerin vaccination and cancer prevention: a critical review of the human experience
CT  - Bacillus Calmette-Guerin vaccination and cancer prevention: a critical review of the human experience
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1976/02/01/
VL  - 36
IS  - Feb
SP  - 652
EP  - 654
SN  - 00085472
AD  - Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-3965; Language: English; References: 19; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Studies of the cancer experiences of children vaccinated with BCG vaccines in antituberculosis programs were reviewed and the strengths and weaknesses of each evaluated. There is little evidence that vaccination outside of the neonatal period is effective. If there is an effect of neonatal vaccination, it must convey only a small amount of protection. Follow-up studies adequate to assess the long term effects of such vaccination, particularly the risk of lymphoma, have not been done, and recent evidence indicates that such evaluation is warranted.
KW  - BCG vaccines--cancer-;
KW  - Immunotherapy--BCG vaccines--cancer, prevention, discussion, in children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Smyth, A. C.;
AU  - Wiernik, P. H.;
T1  - Combination chemotherapy of adult acute lymphocytic leukemia
CT  - Combination chemotherapy of adult acute lymphocytic leukemia
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1976/02/01/
VL  - 19
IS  - Feb
SP  - 240
EP  - 245
SN  - 00099236
AD  - Section of Medical Oncology, National Cancer Institute, Baltimore Cancer Research Center at the Univ. of Maryland Hospital, 22 South Greene St., Baltimore, Maryland 21201
N1  - Accession Number: 14-1697; Language: English; Chemical Name: Thioguanine--154-42-7 Vincristine--57-22-7 Dexamethasone--50-02-2 Pyrimethamine--58-14-0 Lomustine--13010-47-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents thioguanine (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents dexamethasone (10:00); AHFS Class: Antineoplastic agents pyrimethamine (10:00); AHFS Class: Antineoplastic agents lomustine; References: 22; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Seventeen adults with previouly untreated acute lymphocytic leukemia received thioguanine, vincristine, dexamethasone (I), and pyrimethamine for remission induction. Nine patients (53%) achieved complete and 5 (30%) partial remissions. Once in complete remission patients were given 2 closely separated consolidation courses followed by monthly maintenance courses of the same regimen with the addition of lomustine every other month during maintenance therapy. The median duration of complete remission was 176 days (range 38 to 605). The median survival for all patients was 405 days (range 30 to 1,058). Oral pyrimethamine and lomustine were used for their potential activity as prophylactics against meningeal leukemia. I was used instead of prednisone because of the potential enhancement of granulocyte mobilization by the former. Six patients (35%) developed meningeal leukemia while on initial induction or maintenance therapy, 5 within 6 months of diagnosis. Life threatening infections occurred in 10 patients (59%) during induction. Whereas the regimen effectively induced complete remission in about half of previously untreated adults, it was not effective in maintenance. The incidence of meningeal leukemia and infection during induction was high. Pyrimethamine was inadequate prophylaxis for meningeal leukemia; I did not reduce the incidence of serious infection.
KW  - Thioguanine--dexamethasone, pyrimethamine and vincristine-;
KW  - Vincristine--dexamethasone, pyrimethamine and thioguanine-;
KW  - Dexamethasone--pyrimethamine, thioguanine and vincristine-;
KW  - Pyrimethamine--dexamethasone, thioguanine and vincristine-;
KW  - Lomustine--combined therapy-;
KW  - Toxicity--antineoplastic agents--combined therapy, meningeal leukemia and infections, patients;
KW  - Combined therapy--antineoplastic agents--leukemias, acute lymphocytic, therapy, patients;
KW  - Antineoplastic agents--thioguanine--combined therapy, acute lymphocytic leukemia, patients;
KW  - Antineoplastic agents--vincristine--combined therapy, acute lymphocytic leukemia, patients;
KW  - Antineoplastic agents--dexamethasone--combined therapy, acute lymphocytic leukemia, patients;
KW  - Antineoplastic agents--pyrimethamine--combined therapy, acute lymphocytic leukemia, patients;
KW  - Antineoplastic agents--lomustine--combined therapy, acute lymphocytic leukemia, maintenance, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Shellow, R.;
T1  - Drug abuse and crime: fact or fancy?
CT  - Drug abuse and crime: fact or fancy?
JO  - Contemporary Drug Problems (USA)
JF  - Contemporary Drug Problems (USA)
Y1  - 1976/02/01/
VL  - 5
IS  - Feb
SP  - 131
EP  - 147
SN  - 00914509
AD  - National Institute on Drug Abuse, Washington, D.C.
N1  - Accession Number: 14-4597; Language: English; References: 30; Journal Coden: CDGPAI; Section Heading: Sociology, Economics and Ethics; Abstract Author: D. L. Thompson
N2  - Research needs related to the relationship between criminal behavior and drug use are discussed with reference to the work of the Panel on Drug Use and Criminal Behavior convened by the National Institute of Drug Abuse.
KW  - Drug abuse--and crime--relationships, research needs;
KW  - Crime--and drug abuse--relationships, research needs;
KW  - Research--drug abuse--relationships, crime;
KW  - Sociology--drug abuse--and crime, relationships, research needs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DuPont, R. L.;
T1  - Future of Federal drug abuse research. How can we best maximize scarce resources?
CT  - Future of Federal drug abuse research. How can we best maximize scarce resources?
JO  - Drug Alcohol Depend.
JF  - Drug Alcohol Depend.
Y1  - 1976/02/01/
VL  - 1
IS  - Feb
SP  - 233
EP  - 240
AD  - National Institute on Drug Abuse, Rockville, Maryland
N1  - Accession Number: 14-0906; Language: English; Journal Coden: DADEDV; Section Heading: Sociology, Economics and Ethics
N2  - Presented, are some of the accomplishments and longer range objectives of the government's drug abuse research effort, and the problems with which they are now confronted.
KW  - Research--drug abuse--United States, government programs;
KW  - Drug abuse--research--United States, government programs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - NEWS
AU  - Brown, Bertram S.
T1  - How do mental health and aging affect each other? New center will encourage search for answers.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1976/02//
VL  - 31
IS  - 2
M3  - Editorial
SP  - 40
EP  - 44
SN  - 0016867X
N1  - Accession Number: 17208317; Brown, Bertram S. 1,2; Source Information: Feb1976, Vol. 31 Issue 2, p40; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1383
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Huxley, M.;
T1  - Criteria for a socially sanctionable drug
CT  - Criteria for a socially sanctionable drug
JO  - Interdisciplinary Sci. Rev.
JF  - Interdisciplinary Sci. Rev.
Y1  - 1976/02/01/
VL  - 1
IS  - Feb
SP  - 176
EP  - 182
AD  - National Institute of Mental Health, Washington, D.C. 20852
N1  - Accession Number: 14-2148; Language: English; References: 15; Section Heading: Sociology, Economics and Ethics
N2  - In all recorded history, including accounts of preliterate peoples, there is irrefutable evidence that in practically every culture and every society man has developed techniques or found mechanisms whose psychological, physiological and biological effects have permitted him temporarily to alter the state of this consciousness and thereby escape a world that seems all too present, all too humdrum, all too much with him. The occasional need to alter his state of consciousness appears to be one of man's basic drives. These alterations\M/which must be clearly different by an order of magnitude from man's normal experience and expectations\M/involve one or more of man's senses, his conceptual, cognitive and ideational processes, his mood and emotions, and the integrative functions of his mind. That these alterations appear to be a basic need for psychic release can be seen in the enormous range and variety of the psychobiological consciousness-changing techniques and mechanisms that have been developed and explored, and the multiplicity of purposes to which they have been put. Their very existence is a testament to the efficacy of man's ability to satisfy this need.
KW  - Sociology--drugs--criteria, for a socially sanctionable drug;
KW  - Psychotherapeutic agents--sociology--criteria, for a socially sanctionable drug;
KW  - Research--psychotherapeutic agents--criteria, for a socially sanctionable drug;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06283-024
AN  - 2006-06283-024
AU  - Yarrow, Leon J.
T1  - The Mechanisms of Deprivation.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1976/02//
VL  - 21
IS  - 2
SP  - 126
EP  - 127
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06283-024. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childrearing Attitudes; Childrearing Practices; Mothers; Parental Attitudes; Parental Characteristics. Minor Descriptor: Childhood Development. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Rutter, Michael. The Qualities of Mothering: Maternal Deprivation Reassessed=New York: Aronson, 1974. Pp. 175. $7.50; 1974. Page Count: 2. Issue Publication Date: Feb, 1976. 
AB  - Reviews the book, The Qualities of Mothering: Maternal Deprivation Reassessed by Michael Rutter (1974). This slim volume was first published in paperback in 1972; apparently after the paperback supply was exhausted, it was reprinted in hardcover at several times the original cost. The discussion is organized around six chapters dealing with three broad issues: the qualities of mothering necessary for normal development; the short-term effects of maternal deprivation; and the long-term consequences of deprivation. This last topic is dealt with in two chapters, one on modifying factors and the other subtitled 'possible mechanisms.' The review of the literature is selective and the bases for selection are never specified. For example, although there are 26 pages of bibliography, there is no mention of Spitz and Wolf's classic papers or Fairbairn's theoretical discussion of object relationships. As it is, this volume helps us take stock of what has been accomplished in the past 25 years; the advances are not negligible. It also serves as a reminder that there are still many questions to be resolved. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - maternal deprivation
KW  - mothering
KW  - normal development
KW  - 1976
KW  - Childrearing Attitudes
KW  - Childrearing Practices
KW  - Mothers
KW  - Parental Attitudes
KW  - Parental Characteristics
KW  - Childhood Development
KW  - 1976
U2  - Rutter, Michael. (1974); The Qualities of Mothering: Maternal Deprivation Reassessed; New York: Aronson, 1974. Pp. 175. $7.50
DO  - 10.1037/014946
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SAAVEDRA, JUAN M.
AU  - GROBECKER, HORST
AU  - AXELROD, JULIUS
T1  - Adrenaline-Forming Enzyne in Brainstem: Elevation in Genetic and Experimental Hypertension.
JO  - Science
JF  - Science
Y1  - 1976/02/06/
VL  - 191
IS  - 4226
M3  - Article
SP  - 483
EP  - 484
SN  - 00368075
AB  - The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A1, and A2 regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A1, region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219693; SAAVEDRA, JUAN M. 1; GROBECKER, HORST 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/ 6/1976, Vol. 191 Issue 4226, p483; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSTEIN, JOHN N.
AU  - LEITZ, FRANK B.
T1  - Electric Power from Differences in Salinity: The Dialytic Battery.
JO  - Science
JF  - Science
Y1  - 1976/02/13/
VL  - 191
IS  - 4227
M3  - Article
SP  - 557
EP  - 559
SN  - 00368075
AB  - An array of alternating anion and cation exchange membranes can be used to generate electric power from the free energy of mixing of river and sea waters. A simple mathematical model, which predicts experimental results well, is useful in exploring conditions for optimization of the process. Major, but not impossible, improvements in technology would be required to bring the cost of power from the dialytic battery into line with foreseeable energy prices. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219721; WEINSTEIN, JOHN N. 1; LEITZ, FRANK B. 2; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Bureau of Reclamation, Department of the Interior, Denver, Colorado 80225; Issue Info: 2/13/1976, Vol. 191 Issue 4227, p557; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Di Natale, Paola
AU  - Schechter, Alan N.
AU  - Lepore, Giuseppina Castronuov
AU  - De Lorenzo, Francesco
T1  - Histidyl Transfer Ribonucleic Acid Synthetase from Salmonella typhimurium.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1976/02/15/Feb76 Part 2
VL  - 62
IS  - 2
M3  - Article
SP  - 293
EP  - 298
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Structural requirements for substrate binding to histidyl-tRNA synthetase from Salmonella typhimurium have been investigated using ATP analogues. K; values and the relative binding affinity of the enzyme for these analogues have been determined in the tRNA aminoacylation reaction. The enzyme is highly specific for ATP: no binding was found for GTP, CTP, TTP and UTP. dATP is a very poor substrate for acylation of tRNA, with a Km 40-fold higher than that of ATP. Binding of adenosine 5′-triphosphate requires interactions of the amino group of adenosine and the sugar moiety; the 2′ and the 5′ positions of the ribose appear to be essential for recognition; the phosphate groups enhance the binding. AMP is a noncompetitve inhibitor with ATP. The interaction of histidyl-tRNA synthetase, a dimeric enzyme, with histidine and ATP was examined by fluorescence measurements at equilibrium and by equilibrium dialysis. Binding with L-histidine is significantly tighter at pH 6 than at pH 7, while the ATP binding is independent of pH. The stoichiometry was measured at pH 7.5 by equilibrium dialysis and is 1 moI ATP/mol enzyme and, variably, close to 2 or 1 mol histidine/mol enzyme. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN binding
KW  - LIGASES
KW  - SALMONELLA typhimurium
KW  - ADENOSINE triphosphate
KW  - RIBOSE
KW  - BIOCHEMISTRY
N1  - Accession Number: 13488290; Di Natale, Paola 1 Schechter, Alan N. 1 Lepore, Giuseppina Castronuov 1 De Lorenzo, Francesco 1; Affiliation:  1: 2nd Chair of Biochemistry, 2nd Medical School, University of Naples and the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Feb76 Part 2, Vol. 62 Issue 2, p293; Subject Term: PROTEIN binding; Subject Term: LIGASES; Subject Term: SALMONELLA typhimurium; Subject Term: ADENOSINE triphosphate; Subject Term: RIBOSE; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Fauci, A. S.;
AU  - Dale, D. C.;
AU  - Balow, J. E.;
T1  - Glucocorticosteroid therapy: mechanisms of action and clinical considerations
CT  - Glucocorticosteroid therapy: mechanisms of action and clinical considerations
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/03/01/
VL  - 84
IS  - Mar
SP  - 304
EP  - 315
SN  - 00034819
AD  - National Institute of Allergy and Infectious Diseases, Bldg. 10, Room 11 B-09, NIH, Bethesda, Maryland 22014
N1  - Accession Number: 13-4975; Language: English; References: 129; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Charles D. Ponte
N2  - Current concepts regarding glucocorticosteroids (I) and their use in clinical medicine today, are reviewed, along with explanations of their mechanism of action. I and their effect on granulocyte kinetics and function were discussed. Their effect on the distribution pattern of circulating mononuclear cells and their function is also presented. Finally the clinical use of I and the inherent risk of infectious complications were discussed.
KW  - Steroids, cortico---therapy--and mechanism of action, review;
KW  - Mechanism of action--steroids, cortico---and therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Prescott, James W.
T1  - Violence, pleasure and religion.
JO  - Bulletin of the Atomic Scientists
JF  - Bulletin of the Atomic Scientists
Y1  - 1976/03//
VL  - 32
IS  - 3
M3  - Letter
SP  - 62
EP  - 62
PB  - Bulletin of the Atomic Scientists
SN  - 00963402
N1  - Accession Number: 21595886; Prescott, James W. 1; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, Maryland; Source Info: Mar1976, Vol. 32 Issue 3, p62; Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yarrow, Marian Radke
AU  - Waxler, Carolyn Zahn
AU  - Barrett, David
AU  - Darby, Jean
AU  - King, Robert
AU  - Pickett, Marilyn
AU  - Smith, Judith
T1  - Dimensions and Correlates of Prosocial Behavior in Young Children.
JO  - Child Development
JF  - Child Development
Y1  - 1976/03//
VL  - 47
IS  - 1
M3  - Article
SP  - 118
EP  - 125
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12432721; Yarrow, Marian Radke 1 Waxler, Carolyn Zahn 1 Barrett, David 1 Darby, Jean 1 King, Robert 1 Pickett, Marilyn 1 Smith, Judith 1; Affiliation:  1: National institute of Mental Health.; Source Info: Mar1976, Vol. 47 Issue 1, p118; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1467-8624.ep12432721
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Halverson Jr., Charles F.
AU  - Victor, James B.
T1  - Minor Physical Anomalies and Problem Behavior in Elementary School Children.
JO  - Child Development
JF  - Child Development
Y1  - 1976/03//
VL  - 47
IS  - 1
M3  - Article
SP  - 281
EP  - 285
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12432745; Halverson Jr., Charles F. 1 Victor, James B. 2; Affiliation:  1: National Institute of Mental Health.  2: State University of New York, Albany.; Source Info: Mar1976, Vol. 47 Issue 1, p281; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1467-8624.ep12432745
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12432745&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Federman, Edward J.
AU  - Yang, Raymond K.
T1  - A Critique of "Obstetrical Pain-relieving Drugs as Predictors of Infant Behavior Variability"
JO  - Child Development
JF  - Child Development
Y1  - 1976/03//
VL  - 47
IS  - 1
M3  - Article
SP  - 294
EP  - 296
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12432748; Federman, Edward J. 1 Yang, Raymond K. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Mar1976, Vol. 47 Issue 1, p294; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1467-8624.ep12432748
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kirkpatrick, C. H.
AU  - Ottenson, E. A.
AU  - Smith, T. K.
AU  - Wells, S. A.
AU  - Burdick, J. F.
T1  - Reconstitution of defective cellular immunity with foetal thymus and dialysable transfer factor.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/03//
VL  - 23
IS  - 3
M3  - Article
SP  - 414
EP  - 428
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Extensive studies of a 9-year-old boy with recurrent pulmonary infections and chronic mucocutaneous candidiasis disclosed a severe defect in cell-mediated immunity but normal humoral immune responses. These immunological detects were not improved by initial treatment with transfer factor. Alter receiving a foetal thymus transplant the patient developed positive delayed-type skin tests, could be sensitized with chlorodinitrobenzene, and showed progressive improvement of in vitro lymphocyte functions including spontaneous formation of rosettes with sheep erythrocytes and positive responses to photohaemagglutinin, concanavalin A and allogeneic leucocytes. Moreover, lymph node cellularity increased, especially in the thymus-dependent zones.   Though the in vitro responses persisted for over 1 year, skin tests became Unreactive at 38 weeks. However, in contrast to the pre-transplant experience transfer factor was now effective in inducing positive skin tests. These studies provide a chronological account of the effect of the thymus on expression of lymphocyte-mediated immune responses in man and suggest  that thymus-derived cells are required for acquisition of transfer factor-induced cellular immunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDOCRINE glands
KW  - LYMPHOID tissue
KW  - IMMUNITY
KW  - IMMUNOLOGY
KW  - BLOOD cells
KW  - LEUCOCYTES
N1  - Accession Number: 15985291; Kirkpatrick, C. H. 1,2 Ottenson, E. A. 1,2 Smith, T. K. 1,2 Wells, S. A. 1,2 Burdick, J. F. 1,2; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.  2: Infectious Diseases and Surgery Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1976, Vol. 23 Issue 3, p414; Subject Term: ENDOCRINE glands; Subject Term: LYMPHOID tissue; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; Subject Term: BLOOD cells; Subject Term: LEUCOCYTES; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyler, D. J.
T1  - Peripheral lymphocyte subpopulations in human falciparum malaria.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/03//
VL  - 23
IS  - 3
M3  - Article
SP  - 471
EP  - 476
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The concentration of circulating T, B. and 'null' lymphocytes was determined in thirty children and three adults with Plasmodium falciparum infections in West Africa. During infection, both percentage as well as concentration of T cells were decreased as compared to levels following treatment. The percentage but not concentration of B cells was increased. Both percentage and concentration of 'null' cells were increased in malaria. Patients with splenomegaly had the most severe alterations in T-cell number; no other historic or clinical parameter correlated with the degree or pattern of change in circulating lymphocyte sub populations. These alterations were rapidly reversible after anti malarial treatment and presumably represent the sequestration of I cells in the spleen or other organs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - LEUCOCYTES
KW  - PLASMODIUM falciparum
KW  - PATIENTS
KW  - T cells
KW  - PROTOZOAN diseases
N1  - Accession Number: 15985565; Wyler, D. J. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1976, Vol. 23 Issue 3, p471; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: PLASMODIUM falciparum; Subject Term: PATIENTS; Subject Term: T cells; Subject Term: PROTOZOAN diseases; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levis, W. R.
AU  - Whalen, J. J.
AU  - Powell, J. A.
T1  - Specific blastogenesis and lymphokine production in DNCB-sensitive human leucocyte cultures stimulated with soluble and particulate DNP-containing antigens.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/03//
VL  - 23
IS  - 3
M3  - Article
SP  - 481
EP  - 490
PB  - Wiley-Blackwell
SN  - 00099104
AB  - A soluble hapten (dinitrobenzene sulphonic acid (DNBSO3)) and particulate antigens consisting of DNCB, DNFB or DNBSO3 complexed with erythrocytes, all induce a specific blastogenic response and lymphokine production in leucocyte cultures from human subjects topically sensitized to dinitrochlorobenzene (DNCB). While low concentrations (50-100 μg/ml) of DNBSO3 could be left in human leucocyte cultures the entire 4 or 5 days of culture and result in reasonable levels of blastogenesis, it was found that consistently higher degrees of blast transformation resulted when DNCB-sensitive leucocytes were exposed to high concentrations of DNRSO3 (500 μg/ml) for a short period (2 hr). Cell-free supernatants from DNCB-sensitive leucocyte cultures harvested after 48 hr induced blastogenesis and DNA synthesis in secondary target leucocyte cultures from subjects not sensitized to DNCB. Such a blastogenic factor or lymphokine appeared to stimulate even in the absence of any residual antigen, since DNCB complexed to erythrocytes was removed by simple filtration through a 0.45 μm Millepore filter. In contrast to DNCB complexes, the antigenic activity of DNBSO3 completed with erythrocytes was not removed by such filtration. Thus, several DNP-containing haptens (DNCB, DNFB, DNBSO3) induce specific lymphocyte transformation and lymphokine production when exposed in several different manners to leucocytes from humans sensitized to DNCB. The ability to use either a particulate or soluble stimulant in vitro offers a versatile system for studying cell-mediated immunity in humans with a broad range of potential applicability in both investigative and clinical medicine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAPTENS
KW  - ANTIGENS
KW  - ERYTHROCYTES
KW  - LEUCOCYTES
KW  - NUCLEIC acids
KW  - IMMUNITY
N1  - Accession Number: 15985570; Levis, W. R. 1 Whalen, J. J. 1 Powell, J. A. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Mar1976, Vol. 23 Issue 3, p481; Subject Term: HAPTENS; Subject Term: ANTIGENS; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Subject Term: NUCLEIC acids; Subject Term: IMMUNITY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brown, Charles C.
AU  - Muenz, Larry R.
T1  - Reduced Means Square Error Estimation in Contingency Tables.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1976/03//
VL  - 71
IS  - 353
M3  - Article
SP  - 176
SN  - 01621459
AB  - A two-stage estimator is proposed for the cell probabilities in a two-dimensional contingency table. Using a multivariate mean square error criterion, we show that the decision to use either the observed cell probabilities or the estimators assuming row-column independence is approximately dependent upon the noncentrality parameter of the Pearson chi-square statistic chi[sup 2]. We then derive a decision rule that says to use the independence-assumption estimators when chi[sup 2] is less than twice the number of degrees of freedom for testing independence. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MATHEMATICAL models
KW  - PROBABILITY theory
KW  - MATHEMATICAL statistics
KW  - CORRELATION (Statistics)
KW  - DISTRIBUTION (Probability theory)
KW  - STATISTICAL hypothesis testing
KW  - CHI-squared test
N1  - Accession Number: 4609610; Brown, Charles C. 1; Muenz, Larry R. 2; Affiliations: 1: Mathematical statistician, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; 2: Mathematical statistician, International Agency for Research on Cancer, 69008-Lyon, France.; Issue Info: Mar1976, Vol. 71 Issue 353, p176; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICAL hypothesis testing; Subject Term: CHI-squared test; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Lavine, Robert
AU  - Buchsbaum, Monte S.
AU  - Poncy, Mark
T1  - Auditory Analgesia: Somatosensory Evoked Response and Subjective Pain Rating.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1976/03//
VL  - 13
IS  - 2
M3  - Article
SP  - 140
EP  - 148
SN  - 00485772
AB  - Subjective rating responses and averaged evoked responses (AERs) to shock stimuli of varying intensity were recorded in 20 subjects to examine the possible analgesic effects of sound stimulation (music) and suggested analgesia. Subjects (10 men, 10 women, ages 19-31) were divided Into two groups of 10, each receiving the sound-suggestion condition and the no-sound, no-suggestion condition in different order. Sound and suggestion produced the following significant (p <.05) effects: 1) increased electrical stimulus levels required to elicit discomfort ratings; 2) decreased slope of somatosensory AER amplitudes plotted against stimulus intensity; and 3) decreased mean AER amplitudes. These AER effects were greatest In time bands centered mn the P100 component. Prior exposure to the electrical stimuli also reduced AER slopes and mean amplitudes, but mostly in time bands centered on the P200 component. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOKED potentials (Electrophysiology)
KW  - ANALGESICS
KW  - ANTI-inflammatory agents
KW  - AUDITORY evoked response
KW  - AUDITORY perception
KW  - SOMATOSENSORY evoked potentials
KW  - auditory analgesia
KW  - augmentingreducing
KW  - average evoked response
KW  - eeg
KW  - gate theory
KW  - pain
KW  - somatosensory evoked response
KW  - suggestion
N1  - Accession Number: 11685844; Lavine, Robert 1 Buchsbaum, Monte S. 2 Poncy, Mark 1; Affiliation:  1: Department of Physiology, George Washington University Medical Center, Washington, D.C.  2: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland.; Source Info: Mar1976, Vol. 13 Issue 2, p140; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: ANALGESICS; Subject Term: ANTI-inflammatory agents; Subject Term: AUDITORY evoked response; Subject Term: AUDITORY perception; Subject Term: SOMATOSENSORY evoked potentials; Author-Supplied Keyword: auditory analgesia; Author-Supplied Keyword: augmentingreducing; Author-Supplied Keyword: average evoked response; Author-Supplied Keyword: eeg; Author-Supplied Keyword: gate theory; Author-Supplied Keyword: pain; Author-Supplied Keyword: somatosensory evoked response; Author-Supplied Keyword: suggestion; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-8986.ep11685844
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2007-14623-001
AN  - 2007-14623-001
AU  - Waskow, Irene Elkin
T1  - Research on psychotherapy with women: A workshop introduction.
JF  - Psychotherapy: Theory, Research & Practice
JO  - Psychotherapy: Theory, Research & Practice
JA  - Psychotherapy (Chic)
Y1  - 1976///Spr 1976
VL  - 13
IS  - 1
SP  - 64
EP  - 65
CY  - US
PB  - Division of Psychotherapy (29), American Psychological Association
SN  - 0033-3204
AD  - Waskow, Irene Elkin, National Institute of Mental Health, Rockville, MD, US, 20852
N1  - Accession Number: 2007-14623-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research, Practice, Training. Partial author list: First Author & Affiliation: Waskow, Irene Elkin; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation. Release Date: 20071008. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Females; Psychotherapy; Scientific Communication. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 2. Issue Publication Date: Spr 1976. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1976. 
AB  - Introduces a series of articles that came from a workshop on Research on Psychotherapy with Women: Traditional and Alternative Models, which was held at the June 1974 meetings of the Society for Psychotherapy Research. Those of us who were involved in the workshop were very excited by it, felt that many stimulating ideas were raised, and that the papers and discussion gave rise to a number of interesting questions for research as well as for the field of psychotherapy, more generally. We wanted to share the material--and hopefully some of the excitement--of the workshop with others interested in this area. We, therefore, prepared this collection of articles, which consists of revised and edited versions of the papers presented at the workshop and a brief summary of the discussion following the papers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Research on Psychotherapy with Women workshop
KW  - 1976
KW  - Human Females
KW  - Psychotherapy
KW  - Scientific Communication
KW  - 1976
DO  - 10.1037/h0086488
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2007-14624-001
AN  - 2007-14624-001
AU  - Waskow, Irene Elkin
T1  - Summary of discussion following workshop.
JF  - Psychotherapy: Theory, Research & Practice
JO  - Psychotherapy: Theory, Research & Practice
JA  - Psychotherapy (Chic)
Y1  - 1976///Spr 1976
VL  - 13
IS  - 1
SP  - 96
EP  - 98
CY  - US
PB  - Division of Psychotherapy (29), American Psychological Association
SN  - 0033-3204
AD  - Waskow, Irene Elkin, National Institute of Mental Health, Rockville, MD, US, 20852
N1  - Accession Number: 2007-14624-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research, Practice, Training. Partial author list: First Author & Affiliation: Waskow, Irene Elkin; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation. Release Date: 20071008. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Females; Psychotherapy; Scientific Communication. Minor Descriptor: Sexism; Social Issues; Therapist Characteristics; Treatment Outcomes; Values. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Female (40). Page Count: 3. Issue Publication Date: Spr 1976. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1976. 
AB  - Summarizes the highlighted articles from the workshop on Research on Psychotherapy with Women: Traditional and Alternative Models, held at the June 1974 Society for Psychotherapy Research. There were several main themes in the discussion that followed the five presentations: existence of sexism in traditional psychotherapies; role of therapist sex vs. therapist attitudes and ideology; biases in outcome criteria used in research; comparisons of different treatment models for women; values and social issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Research on Psychotherapy with Women workshop
KW  - sexism
KW  - therapists
KW  - treatment outcome criteria
KW  - treatment models
KW  - values
KW  - social issues
KW  - 1976
KW  - Human Females
KW  - Psychotherapy
KW  - Scientific Communication
KW  - Sexism
KW  - Social Issues
KW  - Therapist Characteristics
KW  - Treatment Outcomes
KW  - Values
KW  - 1976
DO  - 10.1037/h0086494
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-14624-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Magrath, I. T.;
AU  - Ziegler, J. L.;
T1  - Failure of BCG immunostimulation to affect the clinical course of Burkitt's lymphoma
CT  - Failure of BCG immunostimulation to affect the clinical course of Burkitt's lymphoma
JO  - British Medical Journal (England)
JF  - British Medical Journal (England)
Y1  - 1976/03/13/
VL  - 1
IS  - Mar 13
SP  - 615
EP  - 618
SN  - 09598146
AD  - Lymphoma Treatment Centre, Makerere Univ. Medical School, Uganda Cancer Institute, Kampala, Uganda
AD  - Reprints: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland
N1  - Accession Number: 13-4267; Language: English; References: 31; Journal Coden: BMJOAE; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - A controlled randomized trial was carried out to evaluate the efficacy of BCG immunotherapy in preventing relapse in patients with Burkitt's lymphoma in whom remission had been induced with cyclophosphamide. Twenty-one patients were treated with BCG, and 19 were controls. Pasteur Institute lyophilized BCG was used; 0.5 ml of a freshly reconstituted suspension containing 150 mg of BCG dry weight and about 13 \X/ 10\SU/8\BS/ viable organisms was given at each application. Scarification was performed on each limb in turn every 4 days for 7 doses and then weekly for 6 doses, giving a total of 10 weeks' immunotherapy. Eleven patients in each group relapsed during a follow-up period long enough to make it unlikely that further relapses would occur. There were no significant differences in the length of remission or the site of relapse that could be attributed to treatment. Eleven patients died: of these none of the 6 patients in the BCG group but all of the 5 in the control group had stage D lymphomas. BCG treatment increased the rate of recovery from tumor induced immunosuppression, but within the BCG group immunocompetence improved most rapidly in the patients who relapsed\M/a finding that appears to contradict the tenet rationalizing the use of immunological adjuvants as treatment.
KW  - BCG vaccines--Burkitt's lymphoma-;
KW  - Immunotherapy--BCG vaccines--Burkitt's lymphoma, lack, effects, on relapse, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - AOKI, TADAO
AU  - LIU, MARGARET
AU  - WALLING, MARY JANE
AU  - BUSHAR, GRACE S.
AU  - BRANDCHAFT, PHYLLIS B.
AU  - KAWAKAMI, THOMAS G.
T1  - Specificity of Naturally Occurring Antibody in Normal Gibbon Serum.
JO  - Science
JF  - Science
Y1  - 1976/03/19/
VL  - 191
IS  - 4232
M3  - Article
SP  - 1180
EP  - 1183
SN  - 00368075
AB  - Gibbon natural antibody examined by immunoelectron microscopy reacted with the entire envelope of type C virus and with areas on the cell surface equivalent to or smaller than the diameter of a virion in gibbon and human culture cells infected with or releasing type C viruses. The antibody activity was absorbed completely by two cell cultures infected with gibbon ape leukemia virus and by the virus itself, and partially by normal gibbon spleen cells and dog thymus-derived cells infected with baboon endogenous type C virus, and fresh white blood cells obtained from a patient with chronic myelogenous leukemia in acute blastic crisis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219858; AOKI, TADAO 1; LIU, MARGARET 1; WALLING, MARY JANE 1; BUSHAR, GRACE S. 1; BRANDCHAFT, PHYLLIS B. 1; KAWAKAMI, THOMAS G. 2; Affiliations: 1: Immunology Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; 2: Comparative Oncology Laboratory, University of California, Davis 95616; Issue Info: 3/19/1976, Vol. 191 Issue 4232, p1180; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FRANKEL, ARTHUR E.
AU  - HAAPALA, DANIEL K.
AU  - NEUBAUER, RICHARD L.
AU  - FISCHINGER, PETER J.
T1  - Elimination of the Sarcoma Genome from Murine Sarcoma Virus Transformed Cat Cells.
JO  - Science
JF  - Science
Y1  - 1976/03/26/
VL  - 191
IS  - 4233
M3  - Article
SP  - 1264
EP  - 1266
SN  - 00368075
AB  - Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revertant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219888; FRANKEL, ARTHUR E. 1; HAAPALA, DANIEL K. 1; NEUBAUER, RICHARD L. 1; FISCHINGER, PETER J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/26/1976, Vol. 191 Issue 4233, p1264; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SITARAM, N.
AU  - WYATT, RICHARD JED
AU  - DAWSON, SUSAN
AU  - GILLIN, J. CHRISTIAN
T1  - REM Sleep Induction by Physostigmine Infusion During Sleep.
JO  - Science
JF  - Science
Y1  - 1976/03/26/
VL  - 191
IS  - 4233
M3  - Article
SP  - 1281
EP  - 1283
SN  - 00368075
AB  - Physostigmine (an anticholinesterase agent that increases acetylcholine at the synapse), in a dose of 0.5 milligram, was given intravenously to seven normal human volunteers. When injected during rapid eye movement (REM) sleep, physostigmine woke the subjects, and when injected during non-REM sleep, it induced REM sleep. This result suggests that cholinergic mechanisms play a role in the induction of REM sleep and in modulating cortical arousal mechanisms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219898; SITARAM, N. 1; WYATT, RICHARD JED 2; DAWSON, SUSAN 2; GILLIN, J. CHRISTIAN 2; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032, and Adult Psychiatry Branch, National Institute of Mental Health; Issue Info: 3/26/1976, Vol. 191 Issue 4233, p1281; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Canellos, G. P.;
AU  - DeVita, V. T.;
AU  - Gold, G. L.;
AU  - Chabner, B. A.;
AU  - Young, R. C.;
AU  - \ET/;
T1  - Combined chemotherapy for advanced breast cancer: response and effect on survival
CT  - Combined chemotherapy for advanced breast cancer: response and effect on survival
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/04/01/
VL  - 84
IS  - Apr
SP  - 389
EP  - 392
SN  - 00034819
AD  - National Cancer Institute, Bldg. 10, Room 12N236, Bethesda, Maryland 20014
N1  - Accession Number: 14-0111; Language: English; Chemical Name: Methotrexate--59-05-2 Cyclophosphamide--6055-19-2 Fluorouracil--51-21-8 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 20; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program, which included methotrexate, 60 mg/sq m, and fluorouracil, 700 mg/sq m, IV on days 1 and 8, in addition to cyclophosphamide, 100 mg/sq m, and prednisone, 40 mg/sq m, orally each day from the first to the fourteenth day of a 28 day cycle. Complete response (8 patients) or partial response (19 patients) was seen in 68% of cases. Lung, soft tissue, and nodal metastases were the most responsive sites. The median duration of antitumor response was 8 months, with a median survival of 18 months for the responding group. The nonresponders had a median survival of 4 months. The toxicity was primarily hematologic and was especially severe in patients with functional liver impairment due to metastatic disease.
KW  - Methotrexate--cyclophosphamide, fluorouracil and prednisone-;
KW  - Cyclophosphamide--fluorouracil, methotrexate and prednisone-;
KW  - Fluorouracil--cyclophosphamide, methotrexate and prednisone-;
KW  - Prednisone--cyclophosphamide, fluorouracil and methotrexate-;
KW  - Antineoplastic agents--methotrexate--combined therapy, metastatic breast cancer, in women;
KW  - Antineoplastic agents--fluorouracil--combined therapy, metastatic breast cancer, in women;
KW  - Antineoplastic agents--cyclophosphamide--combined therapy, metastatic breast cancer, in women;
KW  - Antineoplastic agents--prednisone--combined therapy, metastatic breast cancer, in women;
KW  - Combined therapy--antineoplastic agents--cancer, metastatic breast, in women;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Fauci, A. S.
T1  - Mechanisms of corticosteroid action on lymphocyte subpopulations II. DIFFERENTIAL EFFECTS OF IN VIVO HYDROCORTISONE, PREDNISONE AND DEXAMETHASONE ON IN VITRO EXPRESSION OF LYMPHOCYTE FUNCTION.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/04//
VL  - 24
IS  - 1
M3  - Article
SP  - 54
EP  - 62
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The present study was undertaken to determine what, if any, differential effects various commonly used corticosteroid preparations had on the numbers and specific functions of lymphocyte subpopulations when these agents were administered in equivalent pharmacological dosages. Normal volunteers received a single dose of either 320 trig of hydrocortisone intravenously, 80 mg of prednisone orally, or 12 mg of dexamethasone orally. There was a marked lyrnphocytopenia and monocytopenia maximal 4 6 hr following administration of all three corticosteroid preparations with almost identical kinetics and degree of fail in total cell numbers as well as proportions of thymus-derived and bone marrow-derived lymphocytes. Hydrocortisone and prednisone caused only a slight suppression of phytohaemagglutinin (PHA) induced lymphocyte blastogenesis which could be reversed at supra-optimal concentrations of PHA. On the contrary. dexamethasone administration caused a marked suppression of PHA responses which was not reversed by supra-optimal PHA stimulation. In addition, hydrocortisone and prednisone administration did not suppress non-specific PHA-induced cellular cytotoxicity, while dexamethasone caused a marked suppression (P<0.001) of cytotoxicity. These studies show that although equivalent anti-inflammatory doses of these three corticosteroid preparations cause almost identical suppression of the numbers of circulating lymphocyte populations, they have a differential effect on certain in vitro functional correlates of cell-mediated immunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOID tissue
KW  - LEUCOCYTES
KW  - CELLULAR immunity
KW  - ENDOCRINE glands
KW  - BONE marrow
KW  - HYDROCORTISONE
N1  - Accession Number: 17115771; Fauci, A. S. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Apr1976, Vol. 24 Issue 1, p54; Subject Term: LYMPHOID tissue; Subject Term: LEUCOCYTES; Subject Term: CELLULAR immunity; Subject Term: ENDOCRINE glands; Subject Term: BONE marrow; Subject Term: HYDROCORTISONE; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hamel, Ernest
T1  - Interactions of Guanosine Triphosphate Analogues with Elongation Factor G of <em>Escherichia coli</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1976/04//Apr76 Part 1
VL  - 63
IS  - 2
M3  - Article
SP  - 431
EP  - 440
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Previous studies from this laboratory have shown that the GTP analogue guanosine Y-diphosphate 5′-triphosphate (pppGpp) was almost without activity in the translocation reaction catalyzed by elongation factor G (EF-G), while it was fully active with elongation factor T (EF-T) and initiation factor 2 (IF-2). To assess the importance of the 3′-ribose hydroxyl itself in the translocation reaction, we examined polyphenylalanine synthesis and EF-G-dependent formation of N-acetylphenylalanylphenylalanylpuromycin (Ac-Phe2-puromycin) supported by 3′-deoxyguanosine 5′-triphosphate (YdGTP) and 3′-deoxy-3′-aminoguanosine 5′-triphosphate (3′dNH2GTP). Like pppGpp, these nucleotides were similar to GTP in EF-T and IF-2-dependent reactions. We also examined the ability of the dialcohol derived from GTP by periodate oxidation and borohydride reduction (rroGTP) and of ITP to support translocation. These compounds had shown significant, although reduced, activity with EF-T and IF-2. A spectrum of activity was found with these compounds in both poly(Phe) synthesis and Ac-Phe2-puromycin formation. All had significantly reduced activity relative to GTP, but all were significantly more active than pppGpp. A surprising finding was that the activities of all analogues relative to GTP were dependent on the reaction temperature in both poly(Phe) synthesis and Ac-Phe2-puromycin formation; these relative activities were significantly lower at 8°C than 37°C. Furthermore, the extent of poly(Phe) synthesis with the analogues relative to GTP could be significantly affected by the amounts of EF-G and EF-T in the reaction mixture. Differences were minimized in the presence of rate-limiting EF-T and saturating EF-G and maximized in the presence of rate-limiting EF-G and saturating EF-T. This effect of reducing the level of EF-G in the reaction mixture thus mimicked the effect of lowering the incubation temperature, and a similar observation was made for Ac-Phe2-puromycin formation. GTP-supported formation of Ac-Phe2-puromycin at 8°C could be inhibited by 3′dNH2GTP, YdGTP, pppGpp, and ITP: these compounds were better inhibitors than they were substrates. Inhibition by other nucleotides was also noted. The GTP analogues were compared to GTP as substrates in EF-G-dependent reactions uncoupled from protein synthesis. Fusidic-acid-dependent binding of nucleotides to ribosomes and ribosome-dependent catalytic nucleotide hydrolysis were both examined, and the activity of the nucleotides as substrates in these reactions showed little correlation with their ability to support translocation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUANOSINE triphosphatase
KW  - ESCHERICHIA coli
KW  - BIOCHEMISTRY
KW  - PUROMYCIN
KW  - RAS proteins
KW  - PHOSPHATASES
N1  - Accession Number: 13490344; Hamel, Ernest 1; Affiliation:  1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Apr76 Part 1, Vol. 63 Issue 2, p431; Subject Term: GUANOSINE triphosphatase; Subject Term: ESCHERICHIA coli; Subject Term: BIOCHEMISTRY; Subject Term: PUROMYCIN; Subject Term: RAS proteins; Subject Term: PHOSPHATASES; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Baker, Patricia J.
AU  - Lint, T. F.
AU  - Siegel, Joan
AU  - Kies, Marian W.
AU  - Gewurz, H.
T1  - Potentiation of C¯56-initiated lysis by leucocyte cationic proteins, myelin basic proteins and lysine-rich histones.
JO  - Immunology
JF  - Immunology
Y1  - 1976/04//
VL  - 30
IS  - 4
M3  - Article
SP  - 467
EP  - 473
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Synthetic polycations such as poly-Llysine (PLL) have recently been shown to enhance C&56macr;-initiated lysis by neutralization of serumderived inhibitors of the C&567macr; complex, collectively designated C&567macr;-INH. In the present report we have examined the effect of several naturally occurring polycations on C&56macr;-initiated lysis, Lysosomal granule extracts from rabbit peritoneal exudate cells were found to potentiate C&56macr;-initiated lysis via counteraction of C&567macr;-INH in the fluid phase; this was dependent upon the amount of C&567macr;INH present and independent of cell concentration. The basic proteins of guinea-pig, bovine, and monkey myelin as well as lysine-rich histones also potentiated EC&567macr; formation, but this effect seemed to occur predominantly at the ceil surface. The presence of biologically derived cationic proteins at sites of complement activation during inflammation thus might lead to enhanced tissue damage by favouring the formation of cell-C&567macr; intermediates by either or both of these mechanisms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYSINE
KW  - BASIC proteins
KW  - AMINO acids
KW  - IMMUNITY
KW  - MYELIN basic protein
KW  - HISTONES
N1  - Accession Number: 13358668; Baker, Patricia J. 1 Lint, T. F. 1 Siegel, Joan 1 Kies, Marian W. 1 Gewurz, H. 1; Affiliation:  1: Departments of Immunology, Rush Medical College and Microbiology, University of Illinois at the Medical Center, Chicago, Illinois, and Section of Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland, U.S.A.; Source Info: Apr76, Vol. 30 Issue 4, p467; Subject Term: LYSINE; Subject Term: BASIC proteins; Subject Term: AMINO acids; Subject Term: IMMUNITY; Subject Term: MYELIN basic protein; Subject Term: HISTONES; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Waldrop, Mary F.
AU  - Bell, Richard Q.
AU  - Goering, Jacob D.
T1  - MINOR PHYSICAL ANOMALIES AND INHIBITED BEHAVIOR IN ELEMENTARY SCHOOL GIRLS.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1976/04//
VL  - 17
IS  - 2
M3  - Article
SP  - 113
EP  - 122
SN  - 00219630
AB  - A set of 18 minor physical anomalies has been identified with Down's Syndrome, commonly referred to as mongolism. Most of the general population, however, possess two or more of these anomalies. This dimension represents fast moving, impulsive, clumsy behavior at one extreme and attentive, controlled, well-coordinated behavior at the other extreme. In other words, there is evidence of a genetic or congenital contributor to several aspects of child behavior that are important in basic psychological research on attention, pace, and impulse control, not just a contributor to relatively rare clinical conditions.
KW  - SCHOOL children
KW  - DOWN syndrome
KW  - CHILD psychology
KW  - BEHAVIOR
KW  - CHILD psychopathology
KW  - IMPULSE (Psychology)
N1  - Accession Number: 11903751; Waldrop, Mary F. 1 Bell, Richard Q. 1 Goering, Jacob D. 2; Affiliation:  1: National Institute of Mental Health.  2: University of Maryland.; Source Info: Apr1976, Vol. 17 Issue 2, p113; Subject Term: SCHOOL children; Subject Term: DOWN syndrome; Subject Term: CHILD psychology; Subject Term: BEHAVIOR; Subject Term: CHILD psychopathology; Subject Term: IMPULSE (Psychology); Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1469-7610.ep11903751
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kent, Robert L.
AU  - Lutzner, Marvin A.
AU  - Smith, Kitty P.
T1  - SKIN EXFOLIATION AND PURULENT CONJUNCTIVITIS IN A NEW MUTANT-THE EXFOLIATIVE MOUSE.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/04//
VL  - 66
IS  - 4
M3  - Article
SP  - 248
EP  - 251
SN  - 0022202X
AB  - A spontaneous autosomal recessive mutation has been named the exfoliative mouse (genotype ex/ex). Exfoliative mice suffer a transient purulent conjunctivitis in their 3rd week and an exfoliative skin disease in their 4th week. Gram-negative bacilli are present in blood and cerebrospinal fluid during the conjunctivitis stage, and in skin during the exfoliative period. The mutant can be differentiated from the ichthyotic mouse mutant. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHEMICAL peel
KW  - CONJUNCTIVITIS
KW  - MUTATION (Biology)
KW  - ANIMAL mutation
KW  - MICE
KW  - SKIN diseases
N1  - Accession Number: 12482173; Kent, Robert L. 1 Lutzner, Marvin A. 1 Smith, Kitty P. 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U. S. A.  2: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Apr76, Vol. 66 Issue 4, p248; Subject Term: CHEMICAL peel; Subject Term: CONJUNCTIVITIS; Subject Term: MUTATION (Biology); Subject Term: ANIMAL mutation; Subject Term: MICE; Subject Term: SKIN diseases; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12482173
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Otani, T. T.;
AU  - Briley, M. R.;
T1  - \b/-Hydroxynorleucine: separation of its isomers and biological studies
CT  - \b/-Hydroxynorleucine: separation of its isomers and biological studies
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1976/04/01/
VL  - 65
IS  - Apr
SP  - 534
EP  - 537
SN  - 00223549
AD  - Nucleic Acids Sec., Laboratory of Physiology, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-5576; Language: English; References: 12; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2  - Separation of the 4 isomers of \b/-hydroxynorleucine by column chromatography, synthesis of the corresponding N-chloroacetyl derivatives and screening for antitumor activity in vitro, are discussed.
KW  - \b/-Hydroxynorleucine--isomers-;
KW  - Isomers--\b/-hydroxynorleucine--separation, column chromatography, synthesis and screening of N-chloroacetyl derivatives;
KW  - Chromatography, column--\b/-hydroxynorleucine--isomers, separation, synthesis and screening of N-chloroacetyl derivatives;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-42046-018
AN  - 2013-42046-018
AU  - Shore, Milton F.
T1  - Review of Not for the poor alone: European social services.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1976/04//
VL  - 46
IS  - 2
SP  - 369
EP  - 370
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42046-018. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Services; Language; Social Responsibility; Social Services; Technology. Minor Descriptor: Social Psychology. Classification: Community & Social Services (3373). Population: Human (10). Location: Europe. Reviewed Item: Kahn, Alfred J.; Kamerman, Sheila B. Not for the poor alone: European social services=185 pp. $10.00. Temple University Press, Philadelphia; 1975. Page Count: 2. Issue Publication Date: Apr, 1976. 
AB  - Reviews the book, Not for the Poor Alone: European Social Services by Alfred J. Kahn and Sheila B. Kamerman (1975). Kahn and Kamerman try to describe social welfare services difference in their book. Authors' detail in non-technical language their visits to specific human service programs for all ages in four countries-France, Sweden, Denmark, and the United Kingdom. However, what comes across in this book, and in visits the reviewer has made to many European countries, is the pride in social responsibility and services to others that permeates a large part of these societies. Excitement and optimism pervade the social services of the countries described in the book. This book reads at times like a trip report (with many repetitions), and does not deal with how some of the programs might be adapted to the United States with its greater heterogeneity, its unique history, and its special problems. They also demonstrate how irrelevant are suggestions of loss of individual freedom if similar programs were to be adopted in the United States. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - poor alone
KW  - European social services
KW  - non technical language
KW  - human service programs
KW  - social responsibility
KW  - 1976
KW  - Human Services
KW  - Language
KW  - Social Responsibility
KW  - Social Services
KW  - Technology
KW  - Social Psychology
KW  - 1976
U2  - Kahn, Alfred J.; Kamerman, Sheila B. (1975); Not for the poor alone: European social services; 185 pp. $10.00. Temple University Press, Philadelphia
DO  - 10.1037/h0098749
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - GRALNICK, HARVEY R.
AU  - COLLER, BARRY S.
AU  - SULTAN, YVETTE
T1  - Carbohydrate Deficiency of the Factor VIII/von Willebrand Factor Protein in von Willebrand's Disease Variants.
JO  - Science
JF  - Science
Y1  - 1976/04/02/
VL  - 192
IS  - 4234
M3  - Article
SP  - 56
EP  - 59
SN  - 00368075
AB  - Study of the normal human factor VIII/von Willebrand factor reveals a macromolecular glycoprotein composed of apparently identical subunits. This purified glycoprotein has procoagulant, antigen, and von Willebrand factor activities. In three patients with a variant of the von Willebrand's disease syndrome, their factor VIII/von Willebrand factor protein was present in normal amounts and had normal procoagulant and antigen activities; however, this protein was deficient in both carbohydrate and von Willebrand factor activity. The carbohydrate portion of the factor VIII/von Willebrand factor glycoprotein is of major importance in its interactions with platelets or the blood vessel wall, or both. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219933; GRALNICK, HARVEY R. 1; COLLER, BARRY S. 1; SULTAN, YVETTE 2; Affiliations: 1: Hematology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20014; 2: Hopital Saint-Louis, Paris, France; Issue Info: 4/ 2/1976, Vol. 192 Issue 4234, p56; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - DuPont, R. L.;
AU  - Dormer, R. A.;
AU  - Nightingale, S. L.;
T1  - Treatment of narcotics addiction with narcotic drugs
CT  - Treatment of narcotics addiction with narcotic drugs
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1976/04/12/
VL  - 235
IS  - Apr 12
SP  - 1565
EP  - 1566
AD  - National Institute on Drug Abuse, 11400 Rockville Pike, Rockville, Maryland 20852
N1  - Accession Number: 13-4728; Language: English; Chemical Name: Methadone--76-99-3; References: 4; Journal Coden: JAMAAP; Section Heading: Legislation, Laws and Regulations; Abstract Author: Joan Lentine
N2  - Present U.S. regulations concerning the use of methadone in the treatment of narcotics addiction are discussed.
KW  - Methadone--regulations-;
KW  - Regulations--methadone--dependence, narcotics, therapy, discussion;
KW  - Dependence--narcotics--therapy, methadone, regulations, discussion;
KW  - Narcotics--dependence--therapy, methadone, regulations, discussion;
KW  - Toxicity--narcotics--dependence, methadone therapy, regulations, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - ANFINSEN, CHRISTIAN B.
T1  - Solar Energy.
JO  - Science
JF  - Science
Y1  - 1976/04/16/
VL  - 192
IS  - 4236
M3  - Article
SP  - 198
EP  - 198
SN  - 00368075
N1  - Accession Number: 85363180; ANFINSEN, CHRISTIAN B. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/16/1976, Vol. 192 Issue 4236, p198; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Caffey, E. M.;
AU  - Prein, R. F.;
T1  - Relationship between dosage and response to lithium prophylaxis in recurrent depression
CT  - Relationship between dosage and response to lithium prophylaxis in recurrent depression
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1976/05/01/
VL  - 133
IS  - May
SP  - 567
EP  - 570
SN  - 0002953X
AD  - Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Ln., Rockville, Maryland 20852
N1  - Accession Number: 13-5145; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 14; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: C. Robert Sturwold
N2  - The results of a multihospital collaborative study on the effectiveness of lithium carbonate (I) prophylaxis in recurrent depression were analyzed. Forty-five patients were admitted to the study following hospitalization for acute depression. All had experienced at least one affective mood episode requiring hospitalization during the preceding 2 yr and 2 episodes requiring hospitalization during the preceding 5 yr. Diagnoses were manic-depressive psychosis, depressed type, and recurrent endogenous depression. I was administered at dosages to produce serum lithium levels in the range of 0.5 to 1.2 meq/L. Patients were evaluated every 4 weeks following discharge for a 2 yr period. Of the 32 patients completing the study, recurrent episodes occurred in 53% of those receiving daily doses of one g or less of I compared with 20% for those receiving doses exceeding one g daily. Fifty-five percent of the patients whose I levels were 0.70 meq/L or less experienced recurrent episodes compared with 14% of patients with higher levels. It is suggested that I may be effective prophylactically in the treatment of recurrent depression but emphasize the need for well controlled studies to establish dosage guidelines.
KW  - Lithium carbonate--depression-;
KW  - Dosage--lithium carbonate--depression, recurrent, prophylaxis, and blood levels, in patients;
KW  - Blood levels--lithium carbonate--depression, recurrent, prophylaxis, and dosage, in patients;
KW  - Metabolism--lithium carbonate--blood levels, recurrent depression, prophylaxis, and dosage, in patients;
KW  - Psychotherapeutic agents--lithium carbonate--depression, recurrent, prophylaxis, blood levels and dosage, in patients;
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ER  - 

TY  - JOUR
AU  - Fears, Thomas R.
AU  - Scotto, Joseph
AU  - Schneiderman, Marvin A.
T1  - Skin Cancer, Melanoma, and Sunlight.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1976/05//
VL  - 66
IS  - 5
M3  - Article
SP  - 461
PB  - American Public Health Association
SN  - 00900036
AB  - Recent theoretical studies suggest that the earth's ozone layer which filters ultraviolet radiation may be depleted by a fleet of supersonic transports or by continued use of chlorofluoromethanes. It is now generally accepted that short wavelength ultraviolet radiation leads to the development of skin cancer. In this report we demonstrate an approach to estimating the increase in skin cancer incidence associated with increases in ultraviolet radiation. The purpose is to demonstrate the logic used and the assumptions that must be made when such estimates are made or cited. We emphasize that such estimates should be considered crude until the many assumptions can be investigated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN -- Cancer
KW  - MELANOMA
KW  - ULTRAVIOLET radiation
KW  - NEUROENDOCRINE tumors
KW  - SKIN care
KW  - OZONE layer
KW  - CHLOROFLUOROMETHANE
KW  - STRATOSPHERE
KW  - PUBLIC health
N1  - Accession Number: 5666391; Fears, Thomas R. 1 Scotto, Joseph 2 Schneiderman, Marvin A. 3; Affiliation:  1: Office of Field Studies & Statistics National Cancer Institute, 7910 Woodmont Avenue, Bethesda, MD 20014  2: Demography Section, Biometry Branch, National Cancer Institute  3: Associate Director, Field Studies and Statistics, National Cancer Institute; Source Info: May76, Vol. 66 Issue 5, p461; Subject Term: SKIN -- Cancer; Subject Term: MELANOMA; Subject Term: ULTRAVIOLET radiation; Subject Term: NEUROENDOCRINE tumors; Subject Term: SKIN care; Subject Term: OZONE layer; Subject Term: CHLOROFLUOROMETHANE; Subject Term: STRATOSPHERE; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carrel
T1  - Serfdom's Legacy: An Ethnic Continuum.
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1976/05//
VL  - 81
IS  - 6
M3  - Article
SP  - 1265
EP  - 1286
SN  - 00029602
AB  - The effects of ethnicity appear to occur along a historically determined continuum which reflects the social, legal, economic, and occupational conditions of the European countries from which American ethnic groups emigrated. Ethnic groups with a recent history of serfdom show the intellectual inflexibility, authoritarianism, and pragmatic legalistic morality previously found characteristic of American men working under occupational conditions limiting the individual's opportunity for self-direction. Although it is impossible to confirm each link in the causal chain, a model emphasizing the effects on ethnic groups' culture of historical conditions restricting the individual's autonomy seems a probable and parsimonious explanation of contemporary ethnic differences. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Sociology is the property of University of Chicago Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ETHNICITY
KW  - GROUP identity
KW  - WORK
KW  - LAW
KW  - RACE
KW  - RACE relations
KW  - EUROPE -- Economic conditions
KW  - EUROPE -- Social conditions
KW  - SERFS
KW  - ETHNIC groups
KW  - EUROPE
KW  - UNITED States
N1  - Accession Number: 15579820; Schooler, Carrel 1; Affiliations: 1 : National Institute of Mental Health;  Source Info: May76, Vol. 81 Issue 6, p1265; Historical Period: 1800 to 1999; Subject Term: ETHNICITY; Subject Term: GROUP identity; Subject Term: WORK; Subject Term: LAW; Subject Term: RACE; Subject Term: RACE relations; Subject Term: EUROPE -- Economic conditions; Subject Term: EUROPE -- Social conditions; Subject Term: SERFS; Subject Term: ETHNIC groups; Subject: EUROPE; Subject: UNITED States; Number of Pages: 22p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Furano, Anthony V.
T1  - The Subcellular Distribution and State of the Elongation Factor Tu in Extracts of <em>Escherichia coli</em>B.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1976/05//May76 Part 1
VL  - 64
IS  - 2
M3  - Article
SP  - 597
EP  - 606
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The concentration of elongation factor Tu (EF-Tu) is about 8 times that of ribosomes in extracts of Escherichia coli B grown in glucose-minimal medium. 90% of the EF-Tu is found in the ribosome-free fraction of the cell and 75% of this is free of other macromolecules as judged by chromatography on Sephadex G-100 ; about 10% is bound to the elongation factor EF-Ts and the remaining 10–l 5% is eluted from Sephadex G-100 earlier than expected for its molecular weight. Tryptic peptide maps of the three forms of EF-Tu are essentially indistinguishable. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESCHERICHIA coli
KW  - ENTEROBACTERIACEAE
KW  - CHROMATOGRAPHIC analysis
KW  - MOLECULAR weights
KW  - DEXTRAN
KW  - ION exchange (Chemistry)
KW  - COLLOIDS
N1  - Accession Number: 13490193; Furano, Anthony V. 1; Affiliation:  1: Laboratory of Bichemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: May76 Part 1, Vol. 64 Issue 2, p597; Subject Term: ESCHERICHIA coli; Subject Term: ENTEROBACTERIACEAE; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: MOLECULAR weights; Subject Term: DEXTRAN; Subject Term: ION exchange (Chemistry); Subject Term: COLLOIDS; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Grove, W. R.;
AU  - Fortner, C. L.;
T1  - Carcinoma of the breast
CT  - Carcinoma of the breast
JO  - J. Am. Pharm. Assoc.
JF  - J. Am. Pharm. Assoc.
Y1  - 1976/05/01/
VL  - NS 16
IS  - May
SP  - 254
EP  - 262
AD  - Clinical Research Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, Univ. of Maryland Hospital, Baltimore, Maryland
N1  - Accession Number: 14-3562; Language: English; References: 22; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: James A. Starner
N2  - Current concepts in the therapy of breast cancer are discussed against a background of the pathology, etiology and diagnosis of the disease.
KW  - Antineoplastic agents--cancer--breast, therapy, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Hodes, Louis
T1  - Selection of descriptors according to discrimination and redundancy. application to chemical structure searching
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1976/05//
VL  - 16
IS  - 2
M3  - Article
SP  - 88
EP  - 93
SN  - 00952338
AB  - Descriptor, for our purposes, will be fragment scrrens in a chemical search system. Given a file of compounds, the discrimination of a set of descriptors can be defined in terms of their incidence and mutual incidence in the file. A theory is developed which provides both a heuristic for selecting descriptors and a method for evaluating their marginal discrimination. These ideas have been used to generate an efficient scrren code for a large file of chemical structures.
N1  - Accession Number: ISTA1102323; Hodes, Louis 1; Affiliations: 1 : National Cancer Institute, National Institutes Of Health, Department Of Health, Education, And Welfare, Bethesda, Maryland;  Source Info: May 1976, Vol. 16 Issue 2, p88; Note: Update Code: 1100; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Elgjo, Kjell
AU  - Hennings, Henry
AU  - Michael, Delores
AU  - Yuspa, Stuart H.
T1  - NATURAL SYNCHRONY OF NEWBORN MOUSE EPIDERMAL CELLS IN VITRO.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/05//
VL  - 66
IS  - 5
M3  - Article
SP  - 292
EP  - 296
SN  - 0022202X
AB  - Epidermal cells were separated from newborn mouse skin and grown on glass chamber slides or in plastic Petri dishes. Cell proliferation was examined at short intervals during the first 3 to 4 days in culture. DNA synthesis was estimated by the incorporation of [³H]thymidine into epidermal DNA, or by the labeling index. The mitotic rate was estimated by blocking mitotic cells with vinblastine. Reasonable agreement was found with the different methods. The cells grew synchronously with peaks of DNA synthesis at 21 to 23 hr, 35 to 40 hr, and 60 hr; peak mitotic rates were seen at 44 to 48 hr and 72 to 76 hr. The cells appeared to grow exponentially during the first 3 to 4 days in culture, with one main cohort of cells dividing during the successive proliferative peaks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - CELLS
KW  - CELL proliferation
KW  - THYMIDINE
KW  - VINBLASTINE
KW  - DNA
KW  - MITOSIS
N1  - Accession Number: 12482235; Elgjo, Kjell 1 Hennings, Henry 1 Michael, Delores 1 Yuspa, Stuart H. 1; Affiliation:  1: In Vitro Pathogenesis Section, Experimental Pathology Branch, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May76, Vol. 66 Issue 5, p292; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: CELL proliferation; Subject Term: THYMIDINE; Subject Term: VINBLASTINE; Subject Term: DNA; Subject Term: MITOSIS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12482235
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Throne, Philip R.
AU  - Engel, Bernard T.
AU  - Holmblad, John B.
T1  - An Analysis of the Error Inherent in Estimating Heart Rate From Cardiotachometer Records.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1976/05//
VL  - 13
IS  - 3
M3  - Article
SP  - 269
EP  - 272
SN  - 00485772
AB  - This paper discusses the inherent discrepancy between the mean heart rate computed from a series of cardiotachometer data points and the true average heart rate. A mathematical proof that the man cardiotachometer rate always exceeds the true rate when individual beats are sampled in the presence of variability is given. Examples which illustrate the magnitude of the discrepancy also are presented. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEART beat
KW  - HEMODYNAMICS
KW  - NEUROLOGICAL errors
KW  - MEDICAL equipment
KW  - PSYCHOPHYSIOLOGY
KW  - PSYCHOBIOLOGY
KW  - DESCRIPTORS: Heart rate. Cardiotachometer
KW  - Heart period.
N1  - Accession Number: 11728805; Throne, Philip R. 1 Engel, Bernard T. 1 Holmblad, John B. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging National Institute of Health, PHS US Department of Health Education and Welfare, Bethesda, and the Baltimore City Hospitals.; Source Info: May1976, Vol. 13 Issue 3, p269; Subject Term: HEART beat; Subject Term: HEMODYNAMICS; Subject Term: NEUROLOGICAL errors; Subject Term: MEDICAL equipment; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: PSYCHOBIOLOGY; Author-Supplied Keyword: DESCRIPTORS: Heart rate. Cardiotachometer; Author-Supplied Keyword: Heart period.; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1469-8986.ep11728805
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Alexander, J. C.;
AU  - Silverman, N. A.;
AU  - Chretien, P. B.;
T1  - Effect of age and cigarette smoking on carcinoembryonic antigen levels
CT  - Effect of age and cigarette smoking on carcinoembryonic antigen levels
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1976/05/03/
VL  - 235
IS  - May 3
SP  - 1975
EP  - 1979
AD  - Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-5549; Language: English; References: 16; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Serum carcinoembryonic antigen levels were determined by the Hanzen-Z-gel technique in 276 healthy volunteers, of whom 154 were smokers and 122 nonsmokers. The mean level was significantly higher in smokers (2.7 ng/ml) than in nonsmokers (1.9 ng/ml) (P \LT/ .001), and a significantly higher percentage of smokers had elevated levels (P \LT/ .05). In both groups, levels were directly related to age. Seventy-six of the 154 smokers who entered the study ceased smoking. Their levels were determined at one, 3, and 6 months after cessation of smoking. Within 3 months after cessation, elevated levels declined to within the range of nonsmokers and did not appear to be influenced by previous smoking habits. Both age and smoking history must be considered for accurate evaluation of levels. A reappraisal of the diseases associated with elevated levels that considers the influence of age and smoking may invalidate some of the correlations previously reported.
KW  - Cigarettes--smoking--effects, on serum carcinoembryonic antigen levels, in humans;
KW  - Smoking--cigarettes--effects, on serum carcinoembryonic antigen levels, in humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Williams, R. R.;
T1  - Breast and thyroid cancer and malignant melanoma promoted by alcohol induced pituitary secretion of prolactin, TSH, and MSH
CT  - Breast and thyroid cancer and malignant melanoma promoted by alcohol induced pituitary secretion of prolactin, TSH, and MSH
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/05/08/
VL  - 1
IS  - May 8
SP  - 996
EP  - 999
SN  - 00237507
AD  - National Institutes of Health, N.H.L.I., Landow C-825, Bethesda, Maryland 20014
N1  - Accession Number: 13-4817; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 37; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Toxicity
N2  - In interview data from the U.S.A.'s Third National Cancer Survey, alcohol ingestion was associated with a higher occurrence of cancers of the breast, thyroid, and malignant melanoma. Data from other studies support the first 2 associations. A unifying hypothesis to explain these seemingly diverse associations suggests that alcohol stimulates anterior pituitary secretion of prolactin, thyroid stimulating hormone (TSH), and melanocyte stimulating hormone (MSH). Under the stimulation of these hormones, the 3 target tissues exhibit increased mitotic activity and hence an increased susceptibility to the development of a malignancy. A wide variety of findings from other studies indicate plausibility for this hypothesis. In addition to alcohol, several common drugs acting in a similar manner could be cancer promoters, including: reserpine, methyldopa, phenothiazines, dextroamphetamine, tricyclic antidepressants and antihistamines. Over 20,000 (25%) of all new breast cancer cases each yr could be preventable if this hypothesis is correct.
KW  - Alcohols, ethyl--toxicity-;
KW  - Toxicity--alcohols, ethyl--studies, cancer, mechanism of action, hypothesis;
KW  - Mechanism of action--alcohols, ethyl--cancer, toxicity studies, hypothesis;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - NICHOLS, WARREN W.
AU  - MURPHY, DONALD G.
T1  - Cell Bank Established.
JO  - Science
JF  - Science
Y1  - 1976/05/14/
VL  - 192
IS  - 4240
M3  - Article
SP  - 615
EP  - 615
SN  - 00368075
N1  - Accession Number: 85233137; NICHOLS, WARREN W. 1; MURPHY, DONALD G. 2; Affiliations: 1: Department of Cytogenetices, Institute for Medical Research, Camden, New Jersey 08103; 2: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/14/1976, Vol. 192 Issue 4240, p615; Number of Pages: 1/3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Siris, E. S.;
AU  - Leventhal, B. G.;
AU  - Vaitukaitis, J. L.;
T1  - Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls
CT  - Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1976/05/20/
VL  - 294
IS  - May 20
SP  - 1143
EP  - 1146
SN  - 00284793
AD  - Reproduction Research Branch, National Institute of Child Health and Human Development, Bldg. 10, Rm. 10B09, Bethesda, Maryland 20014
N1  - Accession Number: 13-4818; Language: English; Chemical Name: Vincristine--57-22-7 Methotrexate--59-05-2 Mercaptopurine--6112-76-1 Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents mercaptopurine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 25; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2  - Longer survival in childhood leukemia prompted this study of pubertal development and reproductive function in 35 girls and women who were treated with various chemotherapeutic agents (steroids, vincristine, methotrexate, mercaptopurine and cyclophosphamide). Twenty-eight patients (80%) had normal pubertal progression during a median of 74 months after diagnosis of leukemia and 49 months of chemotherapy. Seven patients were abnormal: 4 exhibited hypothalamicpituitary dysfunction with suppression of circulating serum gonadotropins (\LT/ 6 mIU/ml); 3 others had evidence of primary ovarian dysfunction\M/reversible in 2\M/with inappropriately elevated circulating serum gonadotropins (follicle stimulating hormone \GT/ 20 mIU/ml). Normal sexual development correlated best with pubertal status at onset of leukemia; only one of 17 patients with diagnosis before puberty experienced altered pubertal progression, whereas abnormalities appeared in 6 to 18 with onset during puberty or after menarche. Thus, most girls with aggressively treated childhood leukemia have an excellent prognosis for normal hypothalamic-pituitary-ovarian function; normal development is further enhanced in patients who are prepubertal at onset of leukemia.
KW  - Vincristine--toxicity-;
KW  - Methotrexate--toxicity-;
KW  - Mercaptopurine--toxicity-;
KW  - Cyclophosphamide--toxicity-;
KW  - Steroids--toxicity--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Toxicity--steroids--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Toxicity--vincristine--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Toxicity--methotrexate--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Toxicity--mercaptopurine--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Toxicity--cyclophosphamide--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Antineoplastic agents--vincristine--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Antineoplastic agents--methotrexate--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Antineoplastic agents--mercaptopurine--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW  - Antineoplastic agents--cyclophosphamide--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Whitley, R. J.;
AU  - Chien, L. T.;
AU  - Dolin, R.;
AU  - Galasso, G. J.;
AU  - Alford, C. A.;
AU  - \ET/;
T1  - Adenine arabinoside therapy of herpes zoster in the immunosuppressed: National Institute of Allergy and Infectious Diseases (NIAID) collaborative antiviral study
CT  - Adenine arabinoside therapy of herpes zoster in the immunosuppressed: National Institute of Allergy and Infectious Diseases (NIAID) collaborative antiviral study
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1976/05/27/
VL  - 294
IS  - May 27
SP  - 1193
EP  - 1199
SN  - 00284793
AD  - Reprints: Univ. of Alabama in Birmingham, P.O. Box 313, Rm. 609, C.D.L.D. Bldg., Univ. Station, Birmingham, Alabama 35294
AD  - Depts. of Pediatrics, Microbiology and Clinical Research, Univ. of Alabama in Birmingham, and the National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 13-4846; Language: English; Chemical Name: Adenine--73-24-5; Therapeutic Class: (8:18); AHFS Class: Virucides adenine; References: 31; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Adenine arabinoside (I) treatment of herpes zoster was evaluated in 87 immunodeficient patients in a randomized, controlled crossover study. Patients in group A received I for 5 days followed by placebo for the remaining 5 days. Group B patients received the opposite regimen. I was administered IV over 12 hr at a dosage of 10 mg/kg/day. I was supplied in 5 ml vials at a concentration of 200 mg/ml and because of its low solubility was diluted in standard IV solutions so that the final concentration did not exceed 0.7 mg/ml. In spite of rapid natural healing, those receiving I over the first 5 days had accelerated clearance of virus from vesicles (P = 0.01), and cessation of new vesicle formation (P = 0.004), and a shorter time to total pustulation (P = 0.01). Factors modifying the response to therapy included age, underlying disease, and the duration of zoster prior to therapy. Clinical toxicity was minimal. Laboratory assessment of bone marrow, liver and renal function showed insignificant alterations as a result of therapy. These studies show that I is a drug with promise for therapy of systemic herpes zoster in immunocompromised patients. I is most efficacious when administered during the first 6 days of disease (P = 0.001) to those who have reticuloendothelial neoplasia (P = 0.001) and are less than 38 yr of age (P = 0.001).
KW  - Adenine--arabinoside-;
KW  - Virucides--adenine--arabinoside, herpes zoster therapy, in immunodeficient patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kopanda, R. T.;
AU  - Post, R. M.;
T1  - Cocaine, kindling, and psychosis
CT  - Cocaine, kindling, and psychosis
JO  - American Journal of Psychiatry (USA)
JF  - American Journal of Psychiatry (USA)
Y1  - 1976/06/01/
VL  - 133
IS  - Jun
SP  - 627
EP  - 634
SN  - 0002953X
AD  - Bldg. 10, Rm. 3S239, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1  - Accession Number: 14-0038; Language: English; Chemical Name: Cocaine--50-36-2; References: 100; Publication Type: Review; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: David M. Iamkis
N2  - A review of evidence indicating that repetitive administration of central nervous system stimulants and other related compounds may be associated with progressive alterations of behavior is presented. It is suggested that psychopathological behavior may be related to an electrical kindling phenomenon in which repetitive subthreshold stimulation of the limbic system is eventually associated with major motor seizures. Studies supporting a pharmacological kindling mechanism by cocaine and amphetamine that produces a psychosis are reviewed, and a discussion of a psychosis model that relates catecholamines, a limbic system focus, and a kindling mechanism is presented.
KW  - Cocaine--dosage schedules-;
KW  - Central nervous system stimulants--dosage schedules--adverse reactions, behavioral alterations, review, humans;
KW  - Dosage schedules--central nervous system stimulants--adverse reactions, behavioral alterations, review, humans;
KW  - Drugs, adverse reactions--central nervous system stimulants--dosage schedules, behavioral alterations, review, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - SOCIAL CLASS AND PARENTAL VALUES: ANOTHER CONFIRMATION OF THE RELATIONSHIP.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1976/06//
VL  - 41
IS  - 3
M3  - Article
SP  - 538
EP  - 545
SN  - 00031224
AB  - The article provides another assessment of the relationship between social class and parental values. The Robert Lynds in their classic community study, "Middletown", initially described the relationship between social class and parental values. The class-values relationship was reconfirmed, and more precisely described, in Melvin L. Kohn's study of Washington, D.C. and was again confirmed, and considerably extended, in Kohn and Carmi Schooler's study of a cross section of fathers throughout the U.S. James D. Wrights' confirm that fathers' social class position is related to their valuation of self-direction for children and that the size of the correlation is remarkably close to what was originally found. They also confirm that the class-values relationship remains substantial even when all other major lines of social demarcation are statistically controlled. They even confirm that social class, controlled on all other major lines of social demarcation, is as strongly related to fathers' valuation of self-direction as are all other major lines of social demarcation combined, controlled only on social class.
KW  - SOCIAL classes
KW  - VALUES (Ethics)
KW  - AESTHETICS
KW  - AUTONOMY (Psychology)
KW  - FATHER & child
KW  - FATHERS
N1  - Accession Number: 15273255; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun76, Vol. 41 Issue 3, p538; Subject Term: SOCIAL classes; Subject Term: VALUES (Ethics); Subject Term: AESTHETICS; Subject Term: AUTONOMY (Psychology); Subject Term: FATHER & child; Subject Term: FATHERS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - REPLY TO WRIGHT AND WRIGHT.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1976/06//
VL  - 41
IS  - 3
M3  - Article
SP  - 548
EP  - 548
SN  - 00031224
AB  - The article presents reply to sociologist James D. Wright and Sonia R. Wright. by Melvin L. Kohn on his comment on the article entitled "social class and parental values for children." Wrights acknowledge--implicitly, by abandoning their original arguments--that the 1973 NORC data cast no doubt on the thesis of the original study. They add, ingenuously, that they never intended to imply otherwise. There are still several secondary issues that separate the view--for example, whether there has been change in paternal valuation of self-direction in the past decade and whether Kohn's use of disparate variables in separate analyses for diverse purposes somehow justifies the Wrights' lumping all these variables together as if they were a meaningful conceptual entity. Moreover, they still ignore both the discussion of social structural variables other than social class in "Class and Conformity" and Carmi Schooler's more extended analysis and interpretation of these variables in subsequent publications.
KW  - SOCIAL structure
KW  - SOCIAL classes
KW  - VALUES (Ethics)
KW  - AUTONOMY (Psychology)
KW  - CHILDREN
KW  - CONFORMITY
KW  - SOCIAL influence
N1  - Accession Number: 15273257; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun76, Vol. 41 Issue 3, p548; Thesaurus Term: SOCIAL structure; Subject Term: SOCIAL classes; Subject Term: VALUES (Ethics); Subject Term: AUTONOMY (Psychology); Subject Term: CHILDREN; Subject Term: CONFORMITY; Subject Term: SOCIAL influence; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Legha, S.;
AU  - Muggia, F. M.;
T1  - Antiestrogens in the treatment of cancer
CT  - Antiestrogens in the treatment of cancer
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/06/01/
VL  - 84
IS  - Jun
SP  - 751
SN  - 00034819
AD  - Cancer Therapy Evaluation, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 14-0399; Language: English; References: 6; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Teresa A. Dunlap
N2  - Some preliminary, unpublished clinical data on the usefulness of antiestrogens in the treatment of various disseminated malignancies are presented. It is recommended that antiestrogens should be investigated in the treatment of cancers of the kidney, prostate, endometrium as well as carcinomas of the ovary, vagina and cervix, since these are also tumors that arise from estrogen target tissues.
KW  - Anti-estrogens--cancer--therapy, patients;
KW  - Antineoplastic agents--anti-estrogens--cancer, therapy, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Jacobs, Blanche S.
AU  - Moss, Howard A.
T1  - Birth Order and Sex of Sibling as Determinants of Mother-Infant Interaction.
JO  - Child Development
JF  - Child Development
Y1  - 1976/06//
VL  - 47
IS  - 2
M3  - Article
SP  - 315
EP  - 322
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12189663; Jacobs, Blanche S. 1 Moss, Howard A. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1976, Vol. 47 Issue 2, p315; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1467-8624.ep12189663
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12189663&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yang, Raymond K.
AU  - Halverson Jr., Charles F.
T1  - A Study of the "Inversion of Intensity" between Newborn and Preschool-Age Behavior.
JO  - Child Development
JF  - Child Development
Y1  - 1976/06//
VL  - 47
IS  - 2
M3  - Article
SP  - 350
EP  - 359
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12189700; Yang, Raymond K. 1 Halverson Jr., Charles F. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1976, Vol. 47 Issue 2, p350; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1467-8624.ep12189700
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12189700&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yaoita, Hideo
AU  - Gullino, Marisa
AU  - Katz, Stephen I.
T1  - HERPES GESTATIONIS ULTRASTRUCTURE AND ULTRASTRUCTURAL LOCALIZATION OF IN VIVO-BOUND COMPLEMENT.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/06//
VL  - 66
IS  - 6
M3  - Article
SP  - 383
EP  - 388
SN  - 0022202X
AB  - Ultrastructural localization of C3 deposition in the skin of two patients with herpes gestationis was determined by using a peroxidase-antiperoxidase multistep technique. The tissue preparations can be stored for long periods of time and identical sections may be used for light and electron microscopic examination. The reaction products were seen throughout the entire lamina lucida and the basal cell plasma membrane appeared to be accentuated. The most remarkable ultrastructural changes in normal-appearing skin were the destruction of the basal cell membranes on the dermal side, localized cytoplasmic dissolution, and intracellular edema unaccompanied by inflammatory cells. Early, nonvesicular lesions showed basal cell degeneration and dermal inflammatory cells. Necrosis and loss of basal cells occurred in the next stage which resulted in microvesieles in which collagen or a well-preserved basal lamina formed the vesicle base. In the later blister stage, the basal lamina was usually lost. It is suggested that damage of basal cell membranes on their dermal side leads to the destruction of basal cells with the subsequent protrusion of epidermal and junctional substances into the dermis. This may result in inflammatory cell infiltration and blister formation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HERPESVIRUS diseases
KW  - DERMIS
KW  - CELL membranes
KW  - CELLS
KW  - ENZYMES
KW  - EDEMA
N1  - Accession Number: 12483011; Yaoita, Hideo 1 Gullino, Marisa 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun76, Vol. 66 Issue 6, p383; Subject Term: HERPESVIRUS diseases; Subject Term: DERMIS; Subject Term: CELL membranes; Subject Term: CELLS; Subject Term: ENZYMES; Subject Term: EDEMA; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12483011
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mulvihill, J. J.;
AU  - Yeager, A. M.;
T1  - Fetal alcohol syndrome
CT  - Fetal alcohol syndrome
JO  - Teratology (USA)
JF  - Teratology (USA)
Y1  - 1976/06/01/
VL  - 13
IS  - Jun
SP  - 345
EP  - 348
SN  - 00403709
AD  - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-6076; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 4; Journal Coden: TJADAB; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: William A. Parker
N2  - The clinical manifestations, etiology, pathogenesis, treatment, and prevention of the fetal alcohol syndrome are discussed.
KW  - Alcohols, ethyl--teratogenicity-;
KW  - Teratogenicity--alcohols, ethyl--syndromes, growth retardation and physical anomalies, following maternal ingestion;
KW  - Placental transfer--alcohols, ethyl--teratogenicity, syndromes, growth retardation and physical anomalies, following maternal ingestion;
KW  - Toxicity--alcohols, ethyl--teratogenicity, syndromes, growth retardation and physical anomalies, following maternal ingestion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - CALLAHAN, ROBERT
AU  - LIEBER, MICHAEL M.
AU  - TODARO, GEORGE J.
AU  - GRAVES, DONALD C.
AU  - FERRER, JORGE F.
T1  - Bovine Leukemia Virus Genes in the DNA of Leukemic Cattle.
JO  - Science
JF  - Science
Y1  - 1976/06/04/
VL  - 192
IS  - 4243
M3  - Article
SP  - 1005
EP  - 1007
SN  - 00368075
AB  - Reverse transcripts of the RNA genome of the bovine leukemia virus (BLV) as well as 125I-labeled BLV RNA hybridize to the DNA of tissues from leukemic cattle with the adult form of the disease but not to bovine thymic lymphoma or normal bovine tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85360915; CALLAHAN, ROBERT 1; LIEBER, MICHAEL M. 1; TODARO, GEORGE J. 1; GRAVES, DONALD C. 2; FERRER, JORGE F. 2,3; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute; 2: National Institutes of Health, Bethesda, Maryland 20014; 3: University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square 19348; Issue Info: 6/ 4/1976, Vol. 192 Issue 4243, p1005; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PEEBLES, PAUL T.
AU  - SCOLNICK, EDWARD M.
AU  - HOWK, RICHARD S.
T1  - Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis.
JO  - Science
JF  - Science
Y1  - 1976/06/11/
VL  - 192
IS  - 4244
M3  - Article
SP  - 1143
EP  - 1145
SN  - 00368075
AB  - A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85360958; PEEBLES, PAUL T. 1; SCOLNICK, EDWARD M. 1; HOWK, RICHARD S. 2; Affiliations: 1: Laboratory of Tumor Virus Genetics, National Cancer Institute, Bethesda, Maryland 20014; 2: Meloy Laboratories, Rockville, Maryland 20850; Issue Info: 6/11/1976, Vol. 192 Issue 4244, p1143; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06288-036
AN  - 2006-06288-036
AU  - DuPont, Robert L.
AU  - Ginzburg, Harold M.
T1  - The Confusing State of Drug Abuse Evaluation.
JF  - Contemporary Psychology: APA Review of Books
JO  - Contemporary Psychology: APA Review of Books
Y1  - 1976/07//
VL  - 21
IS  - 7
SP  - 500
EP  - 501
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06288-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: DuPont, Robert L.; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Treatment Effectiveness Evaluation. Minor Descriptor: Health; Social Programs. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Reviewed Item: Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I=Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50; 1974. Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2=Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50; 1974. Page Count: 2. Issue Publication Date: Jul, 1976. 
KW  - drug abuse treatment
KW  - treatment effectiveness
KW  - health programs
KW  - social programs
KW  - 1976
KW  - Drug Abuse
KW  - Drug Rehabilitation
KW  - Treatment Effectiveness Evaluation
KW  - Health
KW  - Social Programs
U2  - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I; Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50
U2  - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2; Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50
DO  - 10.1037/015270
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DP  - EBSCOhost
DB  - pvh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mahal, A. S.;
AU  - Malik, S. C.;
AU  - Srinivasamurthy, U.;
T1  - Evaluation of loxapine succinate as an anxiolytic in comparison with chlordiazepoxide
CT  - Evaluation of loxapine succinate as an anxiolytic in comparison with chlordiazepoxide
JO  - Curr. Ther. Res. Clin. Exp.
JF  - Curr. Ther. Res. Clin. Exp.
Y1  - 1976/07/01/
VL  - 20
IS  - Jul
SP  - 84
EP  - 93
AD  - National Institute of Mental Health and Nuero Sciences, Bangalore, 560 027 India
N1  - Accession Number: 14-4447; Language: English; Chemical Name: Loxapine--1977-10-2 Chlordiazepoxide--58-25-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlordiazepoxide, comparison, loxapine (28:16.08); AHFS Class: Tranquilizers loxapine, comparison, chlordiazepoxide; References: 6; Journal Coden: CTCEA9; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The therapeutic effects of loxapine succinate (I) 6-8 mg/day, were compared in a double blind study with those of chlordiazepoxide (II), 50-60 mg/day, in 60 anxious patients. Forty-two patients completed the 4 week study, 20 from the I group and 22 from the II group. Assessment was done weekly on the Hamilton Rating Scale for Anxiety and Self Rating Symptom Scale (Lipman). After evaluating these patients who were on the active drug, it was found that both the drugs were equally effective. Minor side effects which did not necessitate interruption of treatment were observed in both groups, and appeared comparable, consisting mainly of sedation, tremor, and anticholinergic effects.
KW  - Loxapine--comparison, chlordiazepoxide-;
KW  - Chlordiazepoxide--comparison, loxapine-;
KW  - Tranquilizers--chlordiazepoxide, comparison, loxapine--anxiety, therapy, and side effects, patients;
KW  - Tranquilizers--loxapine, comparison, chlordiazepoxide--anxiety, therapy, and side effects, patients;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-4447&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Butler, Robert N.
T1  - The teaching of geriatric medicine.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1976/07//
VL  - 31
IS  - 7
M3  - Article
SP  - 35
EP  - 35
SN  - 0016867X
N1  - Accession Number: 18942155; Butler, Robert N. 1; Source Information: Jul1976, Vol. 31 Issue 7, p35; Number of Pages: 1/2p; Document Type: Article; Full Text Word Count: 532
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Hunninghake, G. W.
AU  - Fauci, A. S.
T1  - Quantitative and qualitative effects of cyclophosphamide administration on circulating polymorphonuclear leucocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1976/07//
VL  - 31
IS  - 1
M3  - Article
SP  - 139
EP  - 144
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The effect of cyclophosphamide (CY) on the absolute numbers and function of polymorphonuclear leucocytes (PMN) surviving in the circulation following either a single dose (100 mg/kg, i.p.) or daily administration (20 mg/kg, i.p., for 5 days) was studied in the guinea-pig. The quantitative effect of CY on peripheral blood leucocytes was assessed by measuring the absolute numbers of neutrophils, lymphocytes, and monocytes daily for 5 days following the initial injection of CY. The qualitative effects of CY on PMN function were determined by measuring the ability of these cells to function as killer cells. The two functional assays employed were the PMNmediated PHA-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) assays against chicken erythrocyte targets. Both regimens of CY administration produced an equivalent degree of leukopenia 5 days after the initial injection with disproportionately severe neutropenia (<300 PMN/mm³). However, neither regimen of CY administration produced a significant decrease in cytotoxic effector function as measured through a wide range of effector to target cell ratios, PHA concentrations, and antiserum dilutions. These findings have clinical relevance in that they demonstrate the dichotomy between the quantitative and qualitative effects of (CY) on PMNs in that CY administration can dramatically decrease the absolute numbers of circulating polymorphonuclear leucocytes while leaving intact certain effector cell functional capabilities of those PMN surviving in the circulation during drug administration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIBODY-dependent cell cytotoxicity
KW  - MONOCYTES
KW  - LYMPHOCYTES
KW  - NEUTROPHILS
KW  - KILLER cells
KW  - ONTOLOGY
N1  - Accession Number: 13362743; Hunninghake, G. W. 1 Fauci, A. S. 1; Affiliation:  1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul76, Vol. 31 Issue 1, p139; Subject Term: ANTIBODY-dependent cell cytotoxicity; Subject Term: MONOCYTES; Subject Term: LYMPHOCYTES; Subject Term: NEUTROPHILS; Subject Term: KILLER cells; Subject Term: ONTOLOGY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donnelly, Edward F.
AU  - Murphy, Dennis L.
AU  - Waldman, Ivan N.
AU  - Reynolds, Thomas D.
T1  - MMPI DIFFERENCES BETWEEN UNIPOLAR AND BIPOLAR DEPRESSED SUBJECTS: A REPLICATION.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1976/07//
VL  - 32
IS  - 3
M3  - Article
SP  - 610
EP  - 612
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article discusses MMPI, that differences between unipolar and bipolar depressed subjects. Significant differences between groups were found on scales D and PT, but not on MA. Further, scales K, HS, HY, PA, and SI also significantly differentiated the two groups in this study. While the initial study showed sex-related differences on the HS scale only, this study showed that unipolar males had significantly higher scores than unipolar females on scales D, PD, PT, and MA, but unipolar females had significantly higher scores on the SI scale. Bipolar males and females were not differentiated on any scales. It was suggested that differences between groups might be a function of higher anxiety in the unipolar group.
KW  - MINNESOTA Multiphasic Personality Inventory
KW  - FEMALES
KW  - ANXIETY
KW  - STRESS (Psychology)
KW  - BIPOLAR disorder
KW  - MENTAL depression
KW  - GENDER studies
N1  - Accession Number: 15844942; Donnelly, Edward F. 1 Murphy, Dennis L. 2 Waldman, Ivan N. 3 Reynolds, Thomas D. 3; Affiliation:  1: Saint Elizabeths Hospital Washington, DC.  2: National Institute of Menial Health Bethesda, Md.  3: National Institute of Mental Health Washington, D.C.; Source Info: Jul1976, Vol. 32 Issue 3, p610; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: FEMALES; Subject Term: ANXIETY; Subject Term: STRESS (Psychology); Subject Term: BIPOLAR disorder; Subject Term: MENTAL depression; Subject Term: GENDER studies; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yuspa, Stuart H.
AU  - Hennings, Henry
AU  - Saffiotti, Umberto
T1  - CUTANEOUS CHEMICAL CARCINOGENESIS: PAST, PRESENT, AND FUTURE.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/07//
VL  - 67
IS  - 1
M3  - Article
SP  - 199
EP  - 208
SN  - 0022202X
AB  - Skin tumors chemically induced in mice have provided an important experimental model for studying carcinogenesis and for bioassaying carcinogenic agents. The information obtained from this model suggests that the events leading to tumor formation can be divided into at least two stages, initiation and promotion. A single small. dose of carcinogen produces initiation which appears to be irreversible. These initiating agents may have to be metabolically activated and can interact with cellular macromolecules. The extent to which they bind to DNA correlates well with their carcinogenicity. Increased DNA replication at the time of or during the first day after these agents have been applied appears to enhance carcinogenesis. Unlike initiation, promotion appears to be reversible and the promoting agents must be applied repeatedly before tumors are formed. Promoters interact with membranes, stimulate and alter genetic expression, and increase the rate of cell proliferation. The knowledge gained from these studies in mouse skin has immeasurably helped the entire field of chemical carcinogenesis. But efforts to determine the cellular and molecular mechanisms involved in the carcinogenic process, particularly in the skin, have been hampered by the difficulties of working on whole animals and by the special problems associated with the biologic and biochemical methods required for this target organ. Such problems, however, can be solved by the use of cell cultures of mouse epidermis which can metabolize and bind carcinogens just as is done in vivo. The fact that epidermal cells in vitro proliferate synchronously should facilitate the study of the relation between the cell cycle and carcinogenesis. These cells repair chemically induced DNA damage by at least two mechanisms, excision repair and base-specific repair. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TUMORS
KW  - MICE
KW  - DNA
KW  - CELL proliferation
KW  - CELL culture
KW  - CARCINOGENS
N1  - Accession Number: 12513040; Yuspa, Stuart H. 1 Hennings, Henry 1 Saffiotti, Umberto 1; Affiliation:  1: In Vitro Pathogenesis Section, Experimental Pathology Branch ( Carcinogenesis), Division of Cancer Cause and Prevention, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Jul76, Vol. 67 Issue 1, p199; Subject Term: TUMORS; Subject Term: MICE; Subject Term: DNA; Subject Term: CELL proliferation; Subject Term: CELL culture; Subject Term: CARCINOGENS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1523-1747.ep12513040
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12513040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - 
AU  - Wooster, Harold1
T1  - The Case Rests.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
J1  - Journal of the American Society for Information Science
PY  - 1976/07//Jul/Aug1976
Y1  - 1976/07//Jul/Aug1976
VL  - 27
IS  - 4
CP  - 4
M3  - Letter
SP  - 264
EP  - 264
SN  - 00028231
AB  - Presents a letter to the editor in response to an article about the use of library materials, published in a previous issue of the "Journal of the American Society for Information Science."
KW  - Information science
KW  - Periodicals
KW  - Letters to the editor
N1  - Accession Number: 16757962; Authors: Wooster, Harold 1; Affiliations:  1: Special Assistant for Program Development, Lister Hill National Center for Biomedical Communications,National Institutes of Health, Bethesda, MD 20014; Subject: Letters to the editor; Subject: Information science; Subject: Periodicals; Number of Pages: 1/6p; Record Type: Letter
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DP  - EBSCOhost
DB  - lls
ER  - 
TY  - GEN
AU  - Graepel, P H
T1  - Automatic indexing of german language surgical pathology diagnoses
JO  - Methods of Information in Medicine
JF  - Methods of Information in Medicine
Y1  - 1976/07//
VL  - 15
IS  - 3
M3  - Article
SP  - 163
EP  - 167
SN  - 00261270
AB  - Based on experiences with an existing automatic encoding system for english and french language medical data, a simple automatic indexing program for german language surgical pathology diagnoses has been developed. A dictionary of sample index-terms has created reflecting basic information items in an individual user's vocabulary. The dictionary is based on the semantic categorization of the systematized nomenclature of pathology (snop) and open to any numeric coding scheme within this semantic framework. The results of the automatic encoding allow the retrieval of documents (surgical pathology reports) according to practical needs of pathologists and provide an opportunity to study and possibly improve the systematic structure of medical nomenclatures.
N1  - Accession Number: ISTA1103766; Graepel, P H 1; Affiliations: 1 : National Cancer Institute And Division Of Computer Research And Technology, National Institutes Of Health, Bethesda, Maryland;  Source Info: July 1976, Vol. 15 Issue 3, p163; Note: Update Code: 1100; Number of Pages: 5p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1103766&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Engel, Bernard T.
AU  - Gottlieb, Sheldon H.
AU  - Hayhurst, Viola F.
T1  - Tonic and Phasic Relationships Between Heart Rate and Somato-motor Activity in Monkeys.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1976/07//
VL  - 13
IS  - 4
M3  - Article
SP  - 288
EP  - 295
SN  - 00485772
AB  - Heart rate (HR) and somato-motor activity were measured in monkeys (Macaca mulatta) during sessions when the animals were operantly conditioned to stow and to speed HR. Tonic (baseline) levels of HR were independent of somato-motor activity. Phasic changes of HR during conditioning were variably coupled with phasic changes in activity. The discriminative cues which signalled the operant contingencies reliably elicited cardiac operants and somato-motor responses. Monotonic trends in cardiac phasic activity generally were independent of phasic responses in somato-motor activity. Short term phasic responses in HR often were correlated with short term phasic responses in somato-motor responses. The findings indicate that the relationship of HR to somato-motor activity depends upon temporal adjustments within given conditions and stages of training, and upon particular adjustments within each animal. The main conclusion of this study is that HR and somato-motor activity are variably coupled but that conditioned HR responses are not necessarily caused by somato-motor responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEART beat
KW  - MOTOR ability
KW  - TEMPORAL lobes
KW  - ANIMAL experimentation
KW  - PSYCHOPHYSIOLOGY
KW  - PHYSIOLOGY
KW  - Heart rate
KW  - Operant conditioning
KW  - Somato-motor activity.
N1  - Accession Number: 11728811; Engel, Bernard T. 1,2,3 Gottlieb, Sheldon H. 1,2,3 Hayhurst, Viola F. 1,2,3; Affiliation:  1: Gerontology Research Center (Baltimore), National Institute on Aging, National Institute of Health, PHS  2: U.S. Department of Health, Education, and Welfare, Bethesda  3: Baltimore City Hospitals; Source Info: Jul1976, Vol. 13 Issue 4, p288; Subject Term: HEART beat; Subject Term: MOTOR ability; Subject Term: TEMPORAL lobes; Subject Term: ANIMAL experimentation; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Somato-motor activity.; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-8986.ep11728811
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11728811&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06288-036
AN  - 2006-06288-036
AU  - DuPont, Robert L.
AU  - Ginzburg, Harold M.
T1  - The Confusing State of Drug Abuse Evaluation.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1976/07//
VL  - 21
IS  - 7
SP  - 500
EP  - 501
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06288-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: DuPont, Robert L.; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Treatment Effectiveness Evaluation. Minor Descriptor: Health; Social Programs. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Reviewed Item: Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I=Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50; 1974. Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2=Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50; 1974. Page Count: 2. Issue Publication Date: Jul, 1976. 
AB  - Reviews the books, The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I edited by S. B. Sells (1974) and The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2 edited by S. B. Sells (1974). The measurement of treatment effectiveness is one of the most important aspects of contemporary health and social programs. Drug-abuse treatment has been in the forefront of assessment efforts, partly because the controversy surrounding drug abuse led to attempts to 'prove' that treatment worked and partly because the objectives in drug-abuse treatment were clearer than in many other program areas. Saul Sells and his group have been leaders in the efforts to develop new assessment tools. His initial efforts reported in these volumes will confuse many readers because of the complexity of the problems addressed. Nevertheless, no reader should overlook the importance 'of this contribution to the literature of treatment assessment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug abuse treatment
KW  - treatment effectiveness
KW  - health programs
KW  - social programs
KW  - 1976
KW  - Drug Abuse
KW  - Drug Rehabilitation
KW  - Treatment Effectiveness Evaluation
KW  - Health
KW  - Social Programs
KW  - 1976
U2  - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I; Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50
U2  - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2; Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50
DO  - 10.1037/015270
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06288-036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42174-024
AN  - 2013-42174-024
AU  - Shore, Milton F.
T1  - Review of The awareness trap: Self-absorption instead of social change.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1976/07//
VL  - 46
IS  - 3
SP  - 552
EP  - 553
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42174-024. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Gestalt Therapy; Meditation; Psychotherapy; Social Change. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Reviewed Item: Schur, Edwin. The awareness trap: Self-absorption instead of social change=213 pp. $7.95. Quadrangle, New York; 1976. Page Count: 2. Issue Publication Date: Jul, 1976. 
AB  - Reviews the book, The Awareness Trap: Self-Absorption Instead of Social Change by Edwin Schur (see record [rid]1978-08207-000[/rid]). As suggested by its title, this book is an angry indictment of a growing cult in the United States, that of self-gratification psychotherapies such as transcendental meditation, primal scream, encounter groups, nude marathons, gestalt therapy, personal growth groups, and bio-energetics. The author fears that a preoccupation with one’s own experiences at the expense of other people and larger social goals, and a lack of understanding of the role institutional structures play in pathology, will destroy the positive features of the women’s movement and the youth movement, both of which have tried to alter destructive social forces through legal and political challenges. But the author’s anger is a handicap. Rather than developing a thoughtful historical, conceptual, or sociological analysis of why certain groups in our society have become involved in asocial ways of dealing with the world, he uses debate, emotional appeal, persuasion, and argumentation. The author primarily employs select quotations from various sources pieced together in journalistic style, as if he were pleading a case. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - self-absorption
KW  - social change
KW  - self-gratification
KW  - psychotherapy
KW  - meditation
KW  - gestalt therapy
KW  - 1976
KW  - Gestalt Therapy
KW  - Meditation
KW  - Psychotherapy
KW  - Social Change
KW  - 1976
U2  - Schur, Edwin. (1976); The awareness trap: Self-absorption instead of social change; 213 pp. $7.95. Quadrangle, New York
DO  - 10.1037/h0098933
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42174-024&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42174-030
AN  - 2013-42174-030
AU  - Wiener, Jack
T1  - Review of Freud and his followers.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1976/07//
VL  - 46
IS  - 3
SP  - 563
EP  - 565
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42174-030. Partial author list: First Author & Affiliation: Wiener, Jack; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Biographical Data; Freud (Sigmund); Psychoanalysts; Psychoanalytic Theory. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Roazen, Paul. Freud and his followers=599 pp. $15.00. Alfred A. Knopf, New York; 1975. Page Count: 3. Issue Publication Date: Jul, 1976. 
AB  - Reviews the book, Freud and His Followers by Paul Roazen (see record [rid]1975-20049-000[/rid]). Besides the biographical information, a good deal of the book is devoted to Freud’s ideas and those of his followers-many of whom had bitter quarrels with Freud and were banished from Freud’s psychoanalytic group. The book contains new material about Freud from oral interviews with 70 people who knew Freud personally. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Sigmund Freud
KW  - biographical information
KW  - psychoanalytic groups
KW  - 1976
KW  - Biographical Data
KW  - Freud (Sigmund)
KW  - Psychoanalysts
KW  - Psychoanalytic Theory
KW  - 1976
U2  - Roazen, Paul. (1975); Freud and his followers; 599 pp. $15.00. Alfred A. Knopf, New York
DO  - 10.1037/h0098939
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42174-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42174-032
AN  - 2013-42174-032
AU  - Barrett, David E.
T1  - Death penalty discriminators.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1976/07//
VL  - 46
IS  - 3
SP  - 566
EP  - 568
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42174-032. Partial author list: First Author & Affiliation: Barrett, David E.; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Capital Punishment; Juries; Racial and Ethnic Differences; Rape. Minor Descriptor: Judges; Legal Processes. Classification: Criminal Law & Adjudication (4230). Population: Human (10). Page Count: 3. Issue Publication Date: Jul, 1976. 
AB  - Comments on an article by Marvin E. Wolfgang & Marc Riedel (see record [rid]2013-41586-014[/rid]). Wolfgang and Riedel which of several variables were most useful in discriminating between convicted rapists who received the death penalty and those who did not. The variables of interest included characteristics of the defendant and the victim, as well as characteristics of the offense and of the trial proceedings. Based on their analysis, the authors concluded that the variable representing the combination of race of defendant and race of victim best discriminated between the two groups, while neither race of defendant nor race of victim, considered alone, was a significant discriminating variable. However, the results of the discriminant analysis reported by the authors are themselves inconclusive. The variable racial combination of defendant/victim was constructed to test for a statistical interaction between race of defendant and race of victim with regard to death sentence imposition. To determine the contribution to discrimination of such a variable, it is necessary first to account for the separate contributions of the two 'main effect' variables. The authors’ failure to do so precludes the possibility of determining whether the contribution of racial combination per se, over and above the contributions made by the two racial variables considered singly, is significant. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - capital punishment
KW  - death penalty
KW  - racial differences
KW  - rape
KW  - judge
KW  - legal variables
KW  - juries
KW  - 1976
KW  - Capital Punishment
KW  - Juries
KW  - Racial and Ethnic Differences
KW  - Rape
KW  - Judges
KW  - Legal Processes
KW  - 1976
DO  - 10.1037/h0098940
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42174-032&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - CHUANG, D. M.
AU  - HOLLENBECK, R.
AU  - COSTA, E.
T1  - Enhanced Template Activity in Chromatin from Adrenal Medulla After Phosphorylation of Chromosomal Proteins.
JO  - Science
JF  - Science
Y1  - 1976/07/02/
VL  - 193
IS  - 4247
M3  - Article
SP  - 60
EP  - 62
SN  - 00368075
AB  - Translocation of protein kinase to the nucleus had been implicated earlier in the transsynaptic control of gene expression mediated by cholinergic nerves in adrenal medulla. Phosphorylation of chromosomal proteins by adenosine 3',5'-monophosphate-dependent protein kinase and adenosine 3',5'-monophosphate enhances the template activity of chromatin from adrenal medulla. When homologous RNA polymerase II is used the relative activation is greater than that obtained with Escherichia coli RNA polymerase. The substrate for such phosphorylation does not seem to be RNA polymerase II. Phosphorylation of specific acidic protein probably mediates this enhancement of template activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361035; CHUANG, D. M. 1; HOLLENBECK, R. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 7/ 2/1976, Vol. 193 Issue 4247, p60; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SEIFTER, ELI
AU  - COHEN, MAX H.
AU  - RILEY, VERNON
T1  - Of Stress, Vitamin A, and Tumors.
JO  - Science
JF  - Science
Y1  - 1976/07/02/
VL  - 193
IS  - 4247
M3  - Article
SP  - 74
EP  - 75
SN  - 00368075
N1  - Accession Number: 85361042; SEIFTER, ELI 1; COHEN, MAX H. 2; RILEY, VERNON 3; Affiliations: 1: Departments of Biochemistry and Surgery, Albert Einstein College of Medicine, Yeshiva University Bronx, New York 10461; 2: Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Department of Microbiology, Pacific Northwest Research Foundation, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98104; Issue Info: 7/ 2/1976, Vol. 193 Issue 4247, p74; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Byar, D. P.;
AU  - Simon, R. M.;
AU  - Friedewald, W. T.;
AU  - Schlesselman, J. J.;
AU  - DeMets, D. L.;
AU  - \ET/;
T1  - Randomized clinical trials: perspectives on some recent ideas
CT  - Randomized clinical trials: perspectives on some recent ideas
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1976/07/08/
VL  - 295
IS  - Jul 8
SP  - 74
EP  - 80
SN  - 00284793
AD  - Biometry Branch, Clinical and Diagnostic Trials Section, National Cancer Institute, Landow Bldg., Rm. C-509, Bethesda, Maryland 20014
N1  - Accession Number: 13-5654; Language: English; References: 30; Journal Coden: NEJMAG; Section Heading: Methodology
N2  - In spite of the controversy over the role of randomized clinical trials in medical research, the rationale underlying such trials remains persuasive as compared to recent suggestions for alternative nonrandomized studies such as those relying on the use of historical controls and adjustment techniques. It has been suggested that recent statistical innovations for improving clinical trials, including adaptive allocation of treatment to patients and sequential stopping procedures, are underutilized. These innovations, though theoretically interesting, are not easily adapted to large-scale, complex medical trials in which there may be multiple end points and delayed response times. Ethical considerations suggest that randomized trials are more suitable than uncontrolled experimentation in protecting the interest of patients. Randomized clinical trials remain the most reliable method for evaluating the efficacy of therapies.
KW  - Clinical studies--randomized--discussion;
KW  - Methodology--clinical studies--randomized, discussion;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hrushesky, W. J.;
T1  - Serpentine supravenous fluorouracil hyperpigmentation
CT  - Serpentine supravenous fluorouracil hyperpigmentation
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1976/07/12/
VL  - 236
IS  - Jul 12
SP  - 138
AD  - National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-5723; Language: English; Chemical Name: Fluorouracil--51-21-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents fluorouracil; References: 4; Publication Type: Letters; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2  - Markedly increased pigmentation of skin immediately overlying veins used for multiple fluorouracil infusions was noted in a 56-yr-old black man with stage D carcinoma of the prostate who was treated with weekly fluorouracil doses of 750 mg/sq m for 24 consecutive weeks. The total dose of fluorouracil received was 27 g.
KW  - Fluorouracil--injections-;
KW  - Injections--fluorouracil--adverse reactions, skin pigmentation, cancer patient;
KW  - Antineoplastic agents--fluorouracil--injections, skin pigmentation, cancer patient;
KW  - Drug administration--routes--fluorouracil, injections, skin pigmentation, cancer patient;
KW  - Drugs, adverse reactions--fluorouracil--injections, skin pigmentation, cancer patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - SINGER, MAXINE F.
AU  - BERG, PAUL
T1  - Recombinant DNA: NIH Guidelines.
JO  - Science
JF  - Science
Y1  - 1976/07/16/
VL  - 193
IS  - 4249
M3  - Article
SP  - 186
EP  - 188
SN  - 00368075
N1  - Accession Number: 88003069; SINGER, MAXINE F. 1; BERG, PAUL 2; Affiliations: 1: National Cancer Institute, National Institutes of Health Bethesda, Maryland 20014; 2: Department of Biochemistry, Stanford University Medical Center, Stanford, California 94305; Issue Info: 7/16/1976, Vol. 193 Issue 4249, p186; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - SEN, ARUP
AU  - TODARO, GEORGE J.
T1  - Specificity of in vitro Binding of Primate Type C Viral RNA and the Homologous Viral p12 Core Protein.
JO  - Science
JF  - Science
Y1  - 1976/07/23/
VL  - 193
IS  - 4250
M3  - Article
SP  - 326
EP  - 328
SN  - 00368075
AB  - The binding of type C viral p12 proteins to purified viral RNA has been examined in vitro with the use of a family of closely related infectious primate type C viruses-the woolly monkey (SSAV) and gibbon (GALV) group. This in vitro protein- RNA binding is type specific. The system should serve as a model for studies of the evolution of nucleic acid binding proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219969; SEN, ARUP 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/23/1976, Vol. 193 Issue 4250, p326; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - JURGELSKI JR., WILLIAM
AU  - HUDSON, PEARLIE M.
AU  - FALK, HANS L.
AU  - KOTIN, PAUL
T1  - Embryonal Neoplasms in the Opossum: A New Model for Solid Tumors of Infancy and Childhood.
JO  - Science
JF  - Science
Y1  - 1976/07/23/
VL  - 193
IS  - 4250
M3  - Article
SP  - 328
EP  - 332
SN  - 00368075
AB  - Opossums fed the chemical carcinogen ethyl nitrosourea early in postnatal life developed a variety of epithelial and mesenchymal embryonal neoplasms that were closely analogous, in morphology and biological behavior, to tumors of human infancy and childhood for which experimental models in laboratory animals are either imprecise or nonexistent. The embryonal tumors were found in association with, and occasionally at the same sites as, a limited number of malformations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85219970; JURGELSKI JR., WILLIAM 1; HUDSON, PEARLIE M. 1; FALK, HANS L. 1; KOTIN, PAUL 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Johns Manville Corporation, Denver, Colorado 80217; Issue Info: 7/23/1976, Vol. 193 Issue 4250, p328; Number of Pages: 5p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Danforth, D. N.;
AU  - Triche, T.;
AU  - Doppman, J. L.;
AU  - Beazley, R. M.;
AU  - Perrino, P. V.;
AU  - \ET/;
T1  - Elevated plasma proglucagon-like component with a glucagon-secreting tumor: effect of streptozotocin
CT  - Elevated plasma proglucagon-like component with a glucagon-secreting tumor: effect of streptozotocin
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1976/07/29/
VL  - 295
IS  - Jul 29
SP  - 242
EP  - 245
SN  - 00284793
AD  - Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 13-6096; Language: English; Trade Name: Streptozotocin; Generic Name: Streptozocin; Chemical Name: Streptozocin--18883-66-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozocin; References: 19; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2  - To determine the character of the glucagon secretion and its modification by streptozotocin (streptozocin; I), the plasma of a patient with recurrent pancreatic alpha-cell carcinoma was studied. The plasma immunoreactive glucagon level before treatment was 4.80 ng/ml. Biogel column separation of the plasma immunoreactive glucagon revealed 4 components; the predominant component had a molecular weight of 9000 daltons and was designated as proglucagon-like. This fraction constituted 60 to 90% of the total circulating immunoreactive glucagon, and had a biologic activity of 32% of that of an immunoequivalent amount of normal (porcine) pancreatic glucagon. After treatment with streptozotocin (1.5 g/sq m) the plasma immunoreactive glucagon level decreased to 0.24 ng/ml. Treatment was accompanied by a marked reduction in the proglucagon-like component, and the appearance of pancreatic glucagon (molecular weight of 3500 daltons) as the major post-therapy fraction. These findings support the use of I in the management of unresectable glucagon-secreting tumors.
KW  - Streptozocin--tumors-;
KW  - Antineoplastic agents--streptozocin--tumors, glucagon secreting, therapy, in patients;
KW  - Mechanism of action--streptozocin--tumors, glucagon secreting, therapy, in patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mulvihill, J. J.;
AU  - Klimas, J. T.;
AU  - Stokes, D. C.;
AU  - Risemberg, H. M.;
T1  - Fetal alcohol syndrome: seven new cases
CT  - Fetal alcohol syndrome: seven new cases
JO  - American Journal of Obstetrics and Gynecology (USA)
JF  - American Journal of Obstetrics and Gynecology (USA)
Y1  - 1976/08/01/
VL  - 125
IS  - Aug 1
SP  - 937
EP  - 941
SN  - 00029378
AD  - Landow Bldg. Rm. A-521, Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 14-0678; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 16; Journal Coden: AJOGAH; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Teresa A. Martin
N2  - Seven cases of the fetal alcohol syndrome in newborn and older infants are reported.
KW  - Alcohols, ethyl--toxicity-;
KW  - Toxicity--alcohols, ethyl--fetal alcohol syndrome, case reports;
KW  - Placental transfer--alcohols, ethyl--fetal alcohol syndrome, case reports;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Hoff, D. D.;
AU  - Slavik, M.;
AU  - Muggin, F. M.;
T1  - 5-Azacytidine: new anticancer drug with effectiveness in acute myelogenous leukemia
CT  - 5-Azacytidine: new anticancer drug with effectiveness in acute myelogenous leukemia
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/08/01/
VL  - 85
IS  - Aug
SP  - 237
EP  - 245
SN  - 00034819
AD  - Cancer Therapy Evaluation program, Investigational Drug Branch, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-1624; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents azacytidine; References: 73; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Keith P. Lewis
N2  - A review of the laboratory, experimental animal and clinical results of the use of azacytidine is presented. Overall, azacytidine is an effective drug for the treatment of patients with acute myelogenous leukemia who have relapsed after other therapeutic approaches. However, the full potential of this drug is yet to be realized.
KW  - Azacytidine--leukemias-;
KW  - Antineoplastic agents--azacytidine--leukemias, acute myelogenous, therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Fischman, M. W.;
AU  - Schuster, C. R.;
AU  - Resnekov, L.;
AU  - Shick, J. F. E.;
AU  - Krasnegor, N. A.;
AU  - \ET/;
T1  - Cardiovascular and subjective effects of intravenous cocaine administration in humans
CT  - Cardiovascular and subjective effects of intravenous cocaine administration in humans
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1976/08/01/
VL  - 33
IS  - Aug
SP  - 983
EP  - 989
AD  - Reprint: Dept. of Psychiatry, Univ. of Chicago, 950 E. 59th St., Chicago, Illinois 60637
AD  - Univ. of Chicago, Pritzker School of Medicine and National Institute on Drug Abuse, Rockville, Maryland
N1  - Accession Number: 14-3265; Language: English; Chemical Name: Cocaine--50-36-2 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants cocaine, comparison, dextroamphetamine (28:20); AHFS Class: Central nervous system stimulants dextroamphetamine, comparison, cocaine; References: 26; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2  - Dose related increases in heart rate and blood pressure were measured when 9 male volunteers, each with a long history of illicit IV cocaine (I) use, received separate intravenous doses of I 4-32 mg and dextroamphetamine sulfate (II), 10 mg. The cardiovascular effects of 10 mg II had an effect comparable to 8-16 mg I. The mean heart rate averaged 74 beats per min prior to either drug. It increased to 100 beats/min after 16 mg of I and 112 beats/min after 32 mg of the drug. A 10 and 15% rise in systolic blood pressure occurred with the increases in dosages. Behavior data was also collected during the study.
KW  - Cocaine--comparison, dextroamphetamine-;
KW  - Dextroamphetamine--comparison, cocaine-;
KW  - Central nervous system stimulants--cocaine, comparison, dextroamphetamine--injections, IV, physical and psychological effects, dosage, humans;
KW  - Central nervous system stimulants--dextroamphetamine, comparison, cocaine--injections, IV, physical and psychological effects, dosage, humans;
KW  - Injections--cocaine, comparison, dextroamphetamine--intravenous, physical and psychological effects, dosage, humans;
KW  - Injections--dextroamphetamine, comparison, cocaine--intravenous, physical and psychological effects, dosage, humans;
KW  - Dosage--cocaine, comparison, dextroamphetamine--injections, IV, physical and psychological effects, humans;
KW  - Dosage--dextroamphetamine, comparison, cocaine--injections, IV, physical and psychological effects, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Schneider, Edward L.
T1  - HUMAN AGING.
JO  - BioScience
JF  - BioScience
Y1  - 1976/08//
VL  - 26
IS  - 8
M3  - Book Review
SP  - 507
EP  - 507
SN  - 00063568
AB  - The article reviews the book "The Physiology and Pathology of Human Aging," edited by Ralph Goldman and Morris Rockstein.
KW  - Aging
KW  - Nonfiction
KW  - Goldman, Ralph
KW  - Rockstein, Morris
KW  - Physiology & Pathology of Human Aging, The (Book)
N1  - Accession Number: 28049555; Schneider, Edward L. 1; Affiliations: 1 : Laboratory of Cellular & Comparative Physiology Gerontology Research Center, NIH National Institute on Aging HEW Public Health Service Bethesda & Baltimore City Hospitals Baltimore, MD 21224;  Source Info: Aug1976, Vol. 26 Issue 8, p507; Subject Term: Aging; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 308
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
TY  - GEN
AU  - McClane, T. R.;
AU  - Martin, W. R.;
T1  - Subjective and physiologic effects of morphine, pentobarbital, and meprobamate
CT  - Subjective and physiologic effects of morphine, pentobarbital, and meprobamate
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1976/08/01/
VL  - 20
IS  - Aug
SP  - 192
EP  - 198
SN  - 00099236
AD  - National Institute on Drug Abuse, Div. of Research, Addiction Research Center, U.S. Dept. of HEW Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, P.O. Box 12390, Lexington, Kentucky 40511
N1  - Accession Number: 14-2346; Language: English; Chemical Name: Morphine--57-27-2 Meprobamate--57-53-4 Pentobarbital--76-74-4; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers meprobamate, comparison, morphine, pentobarbital (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, meprobamate, pentobarbital; References: 6; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - Pentobarbital (I), morphine (II), and meprobamate (III) were studied in a group of 12 postaddict subjects to determine their effects on subjective states and postrotational nystagmus. I, 150 mg induced a degree of liking and an elevation of the morphine-benzedrine group (MBG) scale score equivalent to 24 mg of II. The effects of I and III on postrotational nystagmus were studied using electro-oculography. Both drugs increased the frequency and prolonged the duration of postrotational nystagmus in a dose related manner. III was about 1/15 as potent as I in enhancing postrotational nystagmus and producing signs of sedation.
KW  - Morphine--comparison, meprobamate, pentobarbital-;
KW  - Meprobamate--comparison, morphine, pentobarbital-;
KW  - Pentobarbital--comparison, meprobamate, morphine-;
KW  - Dosage--meprobamate, comparison, morphine, pentobarbital--effects, subjective, and postrotational nystagmus, humans;
KW  - Dosage--morphine, comparison, meprobamate, pentobarbital--effects, subjective, and postrotational nystagmus, humans;
KW  - Dosage--pentobarbital, comparison, meprobamate, morphine--effects, subjective, and postrotational nystagmus, humans;
KW  - Tranquilizers--meprobamate, comparison, morphine, pentobarbital--effects, subjective, and postrotational nystagmus, dosage, humans;
KW  - Analgesics and antipyretics--morphine, comparison, meprobamate, pentobarbital--effects, subjective, and postrotational nystagmus, dosage, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Amacher, Richard H
AU  - Schneider, John H
T1  - Cancerline: a new nlm/nci data base
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1976/08//
VL  - 16
IS  - 3
M3  - Article
SP  - 128
EP  - 130
SN  - 00952338
AB  - This paper describes collaborative efforts between the national cancer institute (nci) and the national library of medicine (nlm) for the development of a new data base called cancerline. The scope, content, and future enhancements of this on-line file are discussed, as well as the plans for its use to disseminate cancer-related information via nlm's biomedical communications network.
N1  - Accession Number: ISTA1103509; Amacher, Richard H 1; Schneider, John H; Affiliations: 1 : Office Of International Affairs, National Cancer Institute, National Institutes Of Health, Bethesda, Maryland;  Source Info: August 1976, Vol. 16 Issue 3, p128; Note: Update Code: 1100; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - GEN
AU  - Feldmann, Richard J
T1  - An international mass spectral search system (msss). v. a status report
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1976/08//
VL  - 16
IS  - 3
M3  - Article
SP  - 176
EP  - 178
SN  - 00952338
AB  - The status of msss is described. Problems and experiences that have been encountered in three years of commerical operation of this system are reported and discussed.
N1  - Accession Number: ISTA1103583; Feldmann, Richard J 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland;  Source Info: August 1976, Vol. 16 Issue 3, p176; Note: Update Code: 1100; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Stephens, Richard C.
AU  - Levine, Stephen
AU  - Ross, Wesley
T1  - STREET ADDICT VALUES: A FACTOR ANALYTIC STUDY.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1976/08//
VL  - 99
IS  - 2
M3  - Article
SP  - 273
PB  - Taylor & Francis Ltd
SN  - 00224545
N1  - Accession Number: 5391352; Stephens, Richard C. 1,2 Levine, Stephen 1,2 Ross, Wesley 1,2; Affiliation:  1: New York State Drug Abuse Control Commission, New York.  2: National Institute of Mental Health Clinical Research Center, Lexington, Kentucky.; Source Info: Aug1976, Vol. 99 Issue 2, p273; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Johnson, R. E.;
AU  - Brereton, H. D.;
AU  - Kent, C. H.;
T1  - Small cell carcinoma of the lung: attempt to remedy causes of past therapeutic failure
CT  - Small cell carcinoma of the lung: attempt to remedy causes of past therapeutic failure
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/08/07/
VL  - 2
IS  - Aug 7
SP  - 289
EP  - 291
SN  - 00237507
AD  - Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 13-6444; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Doxorubicin--23214-92-8 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents vincristine; References: 5; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - A regimen of intensive, cyclic chemotherapy (cyclophosphamide, vincristine, doxorubicin administered concurrently with radiotherapy) of bulk disease plus prophylactic whole brain irradiation was investigated for small cell carcinoma of the lung in 12 patients. Chemotherapy consisted of cyclic IV administration of doxorubicin (40 mg/sq m), vincristine (2 mg), and cyclophosphamide with all 3 drugs being given on the same day. The dose of cyclophosphamide was 600-1,200 mg/sq m for the first 4 cases and 1,500 mg/sq m in the remaining 17 cases. Chemotherapy was begun on the first day of treatment and cycles were repeated thereafter as soon as the total white blood cell count exceeded 3,500 cells/cu mm. The maximum number of drug cycles was 5 (mean of 4.7 actually given to the 21 patients) and the mean interval between cycles was 20.5 ( 3.7) days. Only 2 patients had a delay of longer than 28 days between any 2 cycles of their chemotherapy. Treatment was completed in 12 weeks, after which patients were observed without maintenance therapy. Complete clinical remissions were noted in 20 of 21 patients with unresectable tumors, 10 of whom had distant extrathoracic spread upon admission. Survival was prolonged and 9 of the 11 patients with regional disease (mediastinal adenopathy with or without pleural effusion and/or supraclavicular nodes) have remained clinically disease free for 6-14 months (median 10) and have resumed normal activities.
KW  - Cyclophosphamide--doxorubicin and vincristine-;
KW  - Doxorubicin--cyclophosphamide and vincristine-;
KW  - Vincristine--cyclophosphamide and doxorubicin-;
KW  - Antineoplastic agents--cyclophosphamide--combined therapy, small cell lung carcinoma, patients;
KW  - Antineoplastic agents--doxorubicin--combined therapy, small cell lung carcinoma, patients;
KW  - Antineoplastic agents--vincristine--combined therapy, small cell lung carcinoma, patients;
KW  - Combined therapy--antineoplastic agents--carcinomas, small cell lung, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - WEINSTEIN, I. BERNARD
AU  - JEFFREY, ALAN M.
AU  - JENNETTE, KAREN W.
AU  - BLOBSTEIN, STEVEN H.
AU  - HARVEY, RONALD G.
AU  - HARRIS, CURTIS
AU  - AUTRUP, HERMAN
AU  - KASAI, HIROSHI
AU  - NAKANISHI, KOJI
T1  - Benzo[a]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in vitro and in vivo.
JO  - Science
JF  - Science
Y1  - 1976/08/13/
VL  - 193
IS  - 4253
M3  - Article
SP  - 592
EP  - 595
SN  - 00368075
AB  - Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo[a]pyrene, (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[aJpyrene, is an intermediate in the binding of benzo[a]pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85220077; WEINSTEIN, I. BERNARD 1; JEFFREY, ALAN M. 1; JENNETTE, KAREN W. 1; BLOBSTEIN, STEVEN H. 1; HARVEY, RONALD G. 2; HARRIS, CURTIS 3; AUTRUP, HERMAN 3; KASAI, HIROSHI 4; NAKANISHI, KOJI 4; Affiliations: 1: Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York 10032; 2: Ben May Laboratory, University of Chicago, Chicago, Illinois 60637; 3: Human Tissue Studies Section, Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014; 4: Chemistry Department, Columbia University, New York 10027; Issue Info: 8/13/1976, Vol. 193 Issue 4253, p592; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BACHUR, NICHOLAS R.
T1  - Cytoplasmic Aldo-Keto Reductases: A Class of Drug Metabolizing Enzymes.
JO  - Science
JF  - Science
Y1  - 1976/08/13/
VL  - 193
IS  - 4253
M3  - Article
SP  - 595
EP  - 597
SN  - 00368075
AB  - Aldehyde and ketone xenobiotic substances are preferentially reduced to alcohols by cytoplasmic enzymes in mammals. These enzymes are widely distributed in the tissues, have broad substrate specificities, have similar physical-chemical characteristics, and require reduced nicotinamide adenine dinucleotide as cofactor for the reductions. These reductases define a system of detoxification for aldehyde and ketone groups. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85220078; BACHUR, NICHOLAS R. 1; Affiliations: 1: Laboratory of Clinical Biochemistry, Baltimore Cancer Research Center, National Cancer Institute, 3100 Wyman Park Drive, Baltimore, Maryland 21211; Issue Info: 8/13/1976, Vol. 193 Issue 4253, p595; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Hoover, R.;
AU  - Gray, L. A.;
AU  - Cole, P.;
AU  - MacMahon, B.;
T1  - Menopausal estrogens and breast cancer
CT  - Menopausal estrogens and breast cancer
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1976/08/19/
VL  - 295
IS  - Aug 19
SP  - 401
EP  - 405
SN  - 00284793
AD  - Environmental Epidemiology Branch, National Cancer Institute, Rm. C525, Landow Bldg., Bethesda, Maryland 20014
N1  - Accession Number: 13-6065; Language: English; References: 33; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations
N2  - A total of 1,891 women given conjugated estrogens for the menopause were followed for 12 yr (mean) for incidence of breast cancer. Overall, 49 cases were observed; 39.1 were expected on the basis of rates in the general population (relative risk = 1.3, P = 0.06). The relative risk increased with follow-up duration, progressing to 2.0 after 15 yr (13/6.6, P = 0.01). The excess risk after 10 yr was not due simply to prolonged estrogen use, since there was no clear dose-response relation to accumulated yr of use. However, higher risk accrued to women using higher-dose tablets and those taking the medication on an other than daily basis. In addition, after 10 yr of follow-up observation, 2 factors related to low risk of breast cancer, multiparity and oophorectomy, were no longer so related. Finally, estrogen used was related to an especially high risk of breast cancer among women in whom benign disease developed after they had started the drug.
KW  - Estrogenic substances--conjugated--toxicity, studies, breast cancer, patients;
KW  - Toxicity--estrogenic substances--conjugated, studies, breast cancer, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - KEBABIAN, JOHN W.
AU  - SAAVEDRA, JUAN M.
T1  - Dopamine-Sensitive Adenylate Cyclase Occurs in a Region of Substantia Nigra Containing Dopaminergic Dendrites.
JO  - Science
JF  - Science
Y1  - 1976/08/20/
VL  - 193
IS  - 4254
M3  - Article
SP  - 683
EP  - 685
SN  - 00368075
AB  - The zona reticulata, the subdivision of the substantia nigra containing dendrites of the dopaminergic nigro-neostriatal neurons, contains dopamine-sensitive adenylate cyclase activity. This nigral dopamine receptor is similar to the striatal dopamine receptor. These and previous data suggest a physiological role (or roles) for dopamine in the substantia nigra. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85220110; KEBABIAN, JOHN W. 1; SAAVEDRA, JUAN M. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 8/20/1976, Vol. 193 Issue 4254, p683; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KUROSAWA, A.
AU  - GUIDOTTI, A.
AU  - COSTA, E.
T1  - Induction of Tyrosine 3-Monooxygenase in Adrenal Medulla: Role of Protein Kinase Activation and Translocation.
JO  - Science
JF  - Science
Y1  - 1976/08/20/
VL  - 193
IS  - 4254
M3  - Article
SP  - 691
EP  - 693
SN  - 00368075
AB  - The transsynaptic induction of tyrosine 3-monooxygenase (TH) in rat adrenal medulla is preceded by an early increase in the ratio of cyclic adenosine monophosphate (AMP) to cyclic guanosine monophosphate, an activation of cytosol cyclic AMP-dependent protein kinase, and a subsequent translocation of protein kinase catalytic subunits from cytosol to subcellular particles. As a result of this translocation, nuclear protein kinase activity increases during the induction of TH. Transection of splanchnic nerve reverts these events and prevents the induction of TH. Thus, adrenal medulla activation and translocation of cyclic AMP-dependent protein kinase may act as a long-range messenger for the genetic regulation of TH synthesis. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85220114; KUROSAWA, A. 1; GUIDOTTI, A. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/20/1976, Vol. 193 Issue 4254, p691; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Brady, Roscoe O.
T1  - Inherited Metabolic Diseases of the Nervous System.
JO  - Science
JF  - Science
Y1  - 1976/08/27/
VL  - 193
IS  - 4255
M3  - Article
SP  - 733
EP  - 739
SN  - 00368075
N1  - Accession Number: 85217928; Brady, Roscoe O. 1; Affiliations: 1: Chief of Developmental and Metabolic Neurology Branch of National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/27/1976, Vol. 193 Issue 4255, p733; Number of Pages: 7p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - SALZMAN, NORMAN P.
T1  - Regulation of Viruses.
JO  - Science
JF  - Science
Y1  - 1976/08/27/
VL  - 193
IS  - 4255
M3  - Article
SP  - 756
EP  - 756
SN  - 00368075
N1  - Accession Number: 85217940; SALZMAN, NORMAN P. 1; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; Issue Info: 8/27/1976, Vol. 193 Issue 4255, p756; Number of Pages: 1/4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Minichiello, Lee
AU  - Retka, Robert
T1  - Trends in Intravenous Drug Abuse as Reflected in National Hepatitis Reporting.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1976/09//
VL  - 66
IS  - 9
M3  - Article
SP  - 872
EP  - 877
PB  - American Public Health Association
SN  - 00900036
AB  - A procedure for obtaining an indicator of trends in illicit intravenous (I.V.) drug use-a form of drug use which is very harmful and difficult to measure-has been developed using national hepatitis surveillance data. Hepatitis reports are separated into two groups: one containing mostly cases related to transmission via I.V. drug use and the other containing cases related to transmission via personal contact and blood transfusion. The analysis of ten years of national hepatitis reporting (1966 to 1975) shows an almost ten-fold rise in drug-related hepatitis cases from 1966 to 1972. In the last three years the number of cases has declined but remains substantially greater than the pre-epidemic levels. The rise in I.V. drug-related cases began in the 1960's among minority groups living in the center cities of the East and West Coasts and spread during the 1970's into the suburbs of these cities and into metropolitan areas throughout the United States. Limitations of this indicator of I.V. drug use relate to the characteristics of the surveillance system and to the underlying relationship of hepatitis to I.V. drug use. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTRAVENOUS therapy
KW  - PARENTERAL therapy
KW  - DRUG abuse
KW  - SUBSTANCE abuse
KW  - BLOOD transfusion
KW  - HEPATITIS
KW  - COMMUNICABLE diseases
KW  - PUBLIC health
KW  - UNITED States
N1  - Accession Number: 5701861; Minichiello, Lee 1 Retka, Robert 2; Affiliation:  1: Science and Technology Division, Institute for Defense Analyses, 400 Army-Navy Drive, Arlington, VA 22202  2: Division of Resource Development, National Institute on Drug Abuse, Rockville, MD; Source Info: Sep76, Vol. 66 Issue 9, p872; Subject Term: INTRAVENOUS therapy; Subject Term: PARENTERAL therapy; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: BLOOD transfusion; Subject Term: HEPATITIS; Subject Term: COMMUNICABLE diseases; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schiffer, C.;
AU  - Weinstein, H.;
AU  - Wiernik, P. H.;
T1  - Methicillin associated thrombocytopenia
CT  - Methicillin associated thrombocytopenia
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/09/01/
VL  - 85
IS  - Sep
SP  - 338
EP  - 339
SN  - 00034819
AD  - Section of Medical Oncology, National Cancer Institute, Baltimore Cancer Research Center at the Univ. of Maryland Hospital, 22 South Greene St., Baltimore, Maryland 21201
N1  - Accession Number: 14-1916; Language: English; Chemical Name: Methicillin--61-32-5; References: 5; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Gail Marie Pezzullo
N2  - A case study of a 41-yr-old woman with acute lymphoblastic leukemia is presented to illustrate thrombocytopenia induced by administration of methicillin (I) 4 g IV every 6 hr. Shortly following chemotherapy with vincristine, dexamethasone, thioguanine and pyrimethamine the patient became febrile, developed oral cellulitis and was treated with carbenicillin and gentamicin. Results of blood cultures revealed \IT/S. aureus\OK/ and antibiotic treatment was changed to I. The infection improved but the patient became thrombocytopenic, unresponsive to multiple platelet transfusions. Upon discontinuation of I and the initiation of cephalothin 3 g IV every 6 hr, the patient's platelet count rose profoundly. Development of phlebitis rendered discontinuation of cephalothin and restarting I. This immediately led to a dramatic fall in platelet count and was again discontinued. Tests for antiplatelet antibody were done using serum obtained throughout the patient's course of treatment and appropriate control sera. Antibody detectable in vitro was noted only in the presence of I and only in the patient's platelet rich plasma and in platelet rich plasma of a normal patient receiving oral cloxacillin. Drug dependent antiplatelet antibody was documented both in vitro and by reexposure in vivo in this patient. No other similar cases have been reported.
KW  - Methicillin--adverse reactions-;
KW  - Drugs, adverse reactions--methicillin--thrombocytopenia, acute lymphoblastic leukemia patient;
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DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Berard, C.;
AU  - Gallo, R.;
AU  - Jaffe, E.;
AU  - Green, I.;
AU  - DeVita, V. T.;
T1  - Current concepts of leukemia and lymphoma: etiology, pathogenesis and therapy
CT  - Current concepts of leukemia and lymphoma: etiology, pathogenesis and therapy
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/09/01/
VL  - 85
IS  - Sep
SP  - 351
EP  - 366
SN  - 00034819
AD  - Lab. of Pathology, National Cancer Institute, Building 10, Room 2A-09, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-2065; Language: English; References: 125; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Gail Marie Pezzullo
N2  - The origin of leukemia, especially acute myelogenous leukemia, and its therapy is presented. Evidence for type-C virus components in human leukemia and the effect of these findings on our understanding of the pathogenesis and pathophysiology of these disorders is discussed. A summary of present knowledge regarding immunologic markers on the cells of these tumors is reported. Trends in the treatment of acute lymphocytic leukemia of childhood, acute myelogenous leukemia, Hodgkin's disease and diffuse histocyte lymphoma are elaborated upon.
KW  - Antineoplastic agents--combined therapy--leukemias, Hodgkin's disease, and lymphomas, disease etiology and current concepts, review;
KW  - Combined therapy--antineoplastic agents--leukemias, Hodgkin's disease, and lymphomas, disease etiology and current concepts, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Adler, William H.
T1  - THYMIC HORMONES.
JO  - BioScience
JF  - BioScience
Y1  - 1976/09//
VL  - 26
IS  - 9
M3  - Book Review
SP  - 569
EP  - 569
SN  - 00063568
AB  - The article reviews the book "The Biological Activity of Thymic Hormones," edited by D. W. Van Bekkum.
KW  - Thymic hormones
KW  - Nonfiction
KW  - Van Bekkum, D. W.
KW  - Biological Activity of Thymic Hormones, The (Book)
N1  - Accession Number: 28049775; Adler, William H. 1; Affiliations: 1 : National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, MD 21224;  Source Info: Sep1976, Vol. 26 Issue 9, p569; Subject Term: Thymic hormones; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 435
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DB  - 8gh
ER  - 

TY  - JOUR
AU  - Coe, J.E.
AU  - Leong, D.
AU  - Portis, J.L.
AU  - Thomas, L.A.
T1  - Immune response in the garter snake (<em>Thamnophis ordinoides<em/>).
JO  - Immunology
JF  - Immunology
Y1  - 1976/09//
VL  - 31
IS  - 3
M3  - Article
SP  - 417
EP  - 424
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Garter snakes (Thamnophis ordinoides) were immunized with hen egg albumin, human gamma-globulin and Keyhole limpet haemocyanin in Freund's adjuvant. Antibody was consistently detected by radioimmunoelectrophoresis and in three different γ- and β-globulin precipitin lines called Ig-M (...20S), Ig-I (...9S) and Ig-2 (....8.5S). Early antibody (day 31 after immunization) was frequently Ig-M whereas Ig-2 and especially Ig-1 were detectable for the longest duration (992 days). After immunization with antigen in Freund's adjuvant, Ig-I serum concentration showed the greatest increase, from almost undetectable levels to the most prominent immunoglobulin in immune serum. [ABSTRACT FROM AUTHOR]
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KW  - GARTER snakes
KW  - IMMUNOLOGICAL adjuvants
KW  - IMMUNIZATION
KW  - ALBUMINS
KW  - GAMMA globulins
KW  - HEMOCYANIN
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 13372762; Coe, J.E. 1 Leong, D. 1 Portis, J.L. 1 Thomas, L.A. 1; Affiliation:  1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Sep76, Vol. 31 Issue 3, p417; Subject Term: GARTER snakes; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: IMMUNIZATION; Subject Term: ALBUMINS; Subject Term: GAMMA globulins; Subject Term: HEMOCYANIN; Subject Term: IMMUNOGLOBULINS; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Shinohara, N.
AU  - Okumura, K.
AU  - Kern, M.
T1  - Differentiation of lymphoid cells: the non-mitogenic induction of immunoglobulin production by thymus cell extract and thymus cell culture filtrate.
JO  - Immunology
JF  - Immunology
Y1  - 1976/09//
VL  - 31
IS  - 3
M3  - Article
SP  - 433
EP  - 441
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The cell-free medium in which thymocytes have been cultured (filtrate) as well as sonic lysates of thymocytes (extract) enhance immunoglobulin production when added to spleen cells during tissue culture. In spite of the requirement for foetal calf serum in the culture medium, production of the enhancing factor in thymocyte culture filtrates occurred even in the presence of a variety of metabolic inhibitors including NaN3, puromycin and hydroxyurea. Although DNA synthesis is required as a prelude to the induction of immunoglobulin production, two lines of evidence indicate that the enhancement produced in response to filtrate and extract occurs via a non-mitogenic process. First, neither cell-free agent was mitogenic toward spleen cells. Secondly, the enhancement of immunoglobulin production due to filtrate or extract was observed even in the presence of inhibitors of DNA synthesis. Multiple functions for thymocytes in the induction of immunoglobulin production are indicated by the findings that thymocytes restore immunoglobulin production of anti-thymocyte serum-treated spleen cells, whereas filtrate and extract, alone or in combination, do not have this capability. Furthermore, filtrate and extract failed to enhance the induction of DNP-group-specific antibody production by cells incubated with DNP-protein, but filtrate and extract could partially restore anti-DNP antibody pro- diction of such anti-thymocyte serum-treated cells. The role of thymocytes, filtrate and extract in the antigen-independent and the antigen-dependent induction of immunoglobulin production is discussed. [ABSTRACT FROM AUTHOR]
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KW  - LYMPHOID tissue
KW  - IMMUNOGLOBULINS
KW  - SPLEEN
KW  - CELL culture
KW  - THYMUS extract
KW  - IMMUNOLOGY
N1  - Accession Number: 13372911; Shinohara, N. 1 Okumura, K. 1 Kern, M. 1; Affiliation:  1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA; Source Info: Sep76, Vol. 31 Issue 3, p433; Subject Term: LYMPHOID tissue; Subject Term: IMMUNOGLOBULINS; Subject Term: SPLEEN; Subject Term: CELL culture; Subject Term: THYMUS extract; Subject Term: IMMUNOLOGY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Coe, J. E.
T1  - Immunoglobulin synthesis by an SV-40-induced hamster lymphoma.
JO  - Immunology
JF  - Immunology
Y1  - 1976/09//
VL  - 31
IS  - 3
M3  - Article
SP  - 495
EP  - 502
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A transplantable lymphoid tumour induced in Syrian hamsters by SV-40 was shown to synthesize a 7Sγ2 monoclonal immunoglobulin which was detectable in the serum of tumour-bearing hamsters. Monoclonal immunoglobulin of the same idiotype was also found in the membrane of the tumour cell. The induction of immunoglobulin synthesizing turnouts by SV-40 should be useful for studies on immunoglobulin synthesis, lymphoid cell receptors and tumour immunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOMAS
KW  - MONOCLONAL antibodies
KW  - IMMUNOGLOBULINS
KW  - IMMUNE serums
KW  - CANCER cells
KW  - CELL membranes
N1  - Accession Number: 13373005; Coe, J. E. 1; Affiliation:  1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Sep76, Vol. 31 Issue 3, p495; Subject Term: LYMPHOMAS; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNE serums; Subject Term: CANCER cells; Subject Term: CELL membranes; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Coe, J. E.
T1  - Immunoglobulin synthesis by an SV-40-induced hamster lymphoma.
JO  - Immunology
JF  - Immunology
Y1  - 1976/09//
VL  - 31
IS  - 3
M3  - Article
SP  - 495
EP  - 502
SN  - 00192805
AB  - A transplantable lymphoid tumour induced in Syrian hamsters by SV-40 was shown to synthesize a 7Sγ2 monoclonal immunoglobulin which was detectable in the serum of tumour-bearing hamsters. Monoclonal immunoglobulin of the same idiotype was also found in the membrane of the tumour cell. The induction of immunoglobulin synthesizing turnouts by SV-40 should be useful for studies on immunoglobulin synthesis, lymphoid cell receptors and tumour immunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOMAS
KW  - MONOCLONAL antibodies
KW  - IMMUNOGLOBULINS
KW  - IMMUNE serums
KW  - CANCER cells
KW  - CELL membranes
N1  - Accession Number: 13373005; Coe, J. E. 1; Source Information: Sep76, Vol. 31 Issue 3, p495; Subject: LYMPHOMAS; Subject: MONOCLONAL antibodies; Subject: IMMUNOGLOBULINS; Subject: IMMUNE serums; Subject: CANCER cells; Subject: CELL membranes; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Kaplan, Allen P.
AU  - Beaven, Michael A.
T1  - IN VIVO STUDIES OF THE PATHOGENESIS OF COLD URTICARIA, CHOLINERGIC URTICARIA, AND VIBRATION-INDUCED SWELLING.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/09//
VL  - 67
IS  - 3
M3  - Article
SP  - 327
EP  - 332
SN  - 0022202X
AB  - The disorders generally classified as physical urticarias include cold urticaria, local and generalized heat urticaria, dermographism, pressure urticaria and vibration-induced angioedema. Cold urticaria is characterized by the rapid development of hives and swelling after exposure to a cold stimulus. It can occur in any age group, has no predilection for either sex and is not associated with other allergic disorders. Cholinergic urticaria or generalized heat urticaria is induced by an increase in body temperature associated with exposure to a hot stimulus or as a consequence of exercise or psychic stimuli.
KW  - URTICARIA
KW  - SKIN -- Inflammation
KW  - ANGIONEUROTIC edema
KW  - ALLERGY
KW  - EDEMA
KW  - CHOLINERGIC mechanisms
N1  - Accession Number: 12514352; Kaplan, Allen P. 1,2 Beaven, Michael A. 1,2; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy, Bethesda, Maryland, U. S. A.  2: Infectious Diseases, and Pulmonary Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Sep76, Vol. 67 Issue 3, p327; Subject Term: URTICARIA; Subject Term: SKIN -- Inflammation; Subject Term: ANGIONEUROTIC edema; Subject Term: ALLERGY; Subject Term: EDEMA; Subject Term: CHOLINERGIC mechanisms; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12514352
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kirkpatrick, Charles H.
AU  - Smith, Terrill K.
T1  - THE NATURE OF TRANSFER FACTOR AND ITS CLINICAL EFFICACY IN THE MANAGEMENT OF CUTANEOUS DISORDERS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/09//
VL  - 67
IS  - 3
M3  - Article
SP  - 425
EP  - 430
SN  - 0022202X
AB  - It was reported that delayed hypersensitivity could be transferred with lymphoid cells from reactive human donors to previously unresponsive recipients. In the experiments transfer factor (TF) has been prepared from peripheral blood leukocytes collected with a continuous-flow blood cell separator or a Latham Blood Processor. The protocol for preparing the TF varies slightly depending upon the plans for the preparation. In some cases whole cell suspensions including leukocytes, erythrocytes and platelets are disrupted by repeated freezing and thawing.
KW  - DELAYED hypersensitivity
KW  - TRANSFER factor (Immunology)
KW  - LYMPHOKINES
KW  - LEUCOCYTES
KW  - BLOOD platelets
KW  - ERYTHROCYTES
N1  - Accession Number: 12514723; Kirkpatrick, Charles H. 1,2 Smith, Terrill K. 1,2; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy, Bethesda, Maryland, U. S. A.  2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Sep76, Vol. 67 Issue 3, p425; Subject Term: DELAYED hypersensitivity; Subject Term: TRANSFER factor (Immunology); Subject Term: LYMPHOKINES; Subject Term: LEUCOCYTES; Subject Term: BLOOD platelets; Subject Term: ERYTHROCYTES; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12514723
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wooster, Harold
T1  - An Experiment in Networking: The LHNCBC Experimental CAI Network, 1971-1975.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
Y1  - 1976/09//Sep-Oct1976
VL  - 27
IS  - 5/6
M3  - Article
SP  - 329
EP  - 338
SN  - 00028231
AB  - This is an administrative history of an information network. In somewhat less than four years, the Lister Hill National Center for Biomedical Communications of the National Library of Medicine built this network, demonstrated a substantial demand for its services, encouraged it to become self-sustaining, and transferred support and operation to a user consortium. The paper is concerned with the process, and some of the problems, of innovation rather than the product, biomedical computer- assisted instruction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INFORMATION networks
KW  - INFORMATION science
KW  - LIBRARIES
KW  - COMPUTER assisted instruction
KW  - ACADEMIC libraries
KW  - MEDICINE
N1  - Accession Number: 16747705; Wooster, Harold 1; Affiliations: 1: Lister Hill National Center for Biomedical Communications National Library of Medicine National Institutes of Health Bethesda, MD 20014.; Issue Info: Sep-Oct1976, Vol. 27 Issue 5/6, p329; Thesaurus Term: INFORMATION networks; Thesaurus Term: INFORMATION science; Thesaurus Term: LIBRARIES; Subject Term: COMPUTER assisted instruction; Subject Term: ACADEMIC libraries; Subject Term: MEDICINE; NAICS/Industry Codes: 519120 Libraries and Archives; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 519121 Libraries; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Gail, Mitchell H.
AU  - Green, Sylvan B.
T1  - Critical Values for the One-Sided Two-Sample Kolmogorov-Smirnov Statistic.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1976/09//
VL  - 71
IS  - 355
M3  - Article
SP  - 757
SN  - 01621459
AB  - We present a new recursion for counting the number of paths which ever attain a given height. Using this recursion, we calculate exact critical values for the one-sided two-sample Kolmogorov-Smirnov statistic for n and m = 3(1)30 and for significance levels alpha = 0.10, 0.05 and 0.01. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICS
KW  - MULTIVARIATE analysis
KW  - ONE (The number)
KW  - RECURSION theory
KW  - PATH analysis (Statistics)
KW  - KOLMOGOROV complexity
KW  - ALTITUDES
N1  - Accession Number: 4607807; Gail, Mitchell H. 1; Green, Sylvan B. 2; Affiliations: 1: Medical Statistical Researcher, National Cancer Institute, Landow Building C-509, Bethesda, MD 20014.; 2: Medical Researcher, National Cancer Institute, Landow Building C-509, Bethesda, MD 20014.; Issue Info: Sep76, Vol. 71 Issue 355, p757; Thesaurus Term: STATISTICS; Thesaurus Term: MULTIVARIATE analysis; Subject Term: ONE (The number); Subject Term: RECURSION theory; Subject Term: PATH analysis (Statistics); Subject Term: KOLMOGOROV complexity; Subject Term: ALTITUDES; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Robinson, R. A.;
AU  - DeVita, V. T.;
AU  - Levy, H. B.;
AU  - Baron, S.;
AU  - Hubbard, S. P.;
AU  - \ET/;
T1  - Phase I-II trial of multiple-dose polyriboinosinic-polyribocytidylic acid in patients with leukemia or solid tumors
CT  - Phase I-II trial of multiple-dose polyriboinosinic-polyribocytidylic acid in patients with leukemia or solid tumors
JO  - Journal of the National Cancer Institute (USA)
JF  - Journal of the National Cancer Institute (USA)
Y1  - 1976/09/01/
VL  - 57
IS  - Sep
SP  - 599
EP  - 602
SN  - 00278874
AD  - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 14-1318; Language: English; Trade Name: Poly I: Poly C; Generic Name: Polyinosinic-polycytidylic acid; Chemical Name: Polyinosinic-polycytidylic acid--24939-03-5; References: 21; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Polyinosinic-polycytidylic acid (I; Poly I: Poly C), was administered in multiple doses of 0.3-75 mg/sq m to 26 patients with a variety of solid tumors, 9 with acute leukemia, and 2 with chronic myelogenous leukemia in blast crisis. Forty-four separate drug trials were comprised of various schedules and routes of administration. Toxic reactions included fever (in 66% of the trials), transient elevation of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase (25%), minimal laboratory evidence of coagulation abnormalities (59%), and hypersensitivity (5%). These toxic manifestations did not relate to dose level or magnitude of interferon induction. I administered IV induced low serum concentrations of interferon in 24/38 trials (63%), but the correlation between drug dose and peak interferon titer was not linear. I administered IV or IM was not effective as an inducer of interferon in the cerebrospinal fluid. Similarly, I administered IM or by inhalation did not produce detectable serum levels of interferon. No patients experienced an objective tumor response to the administration of I, and most (76%) had progression of their disease while receiving the drug.
KW  - Polyinosinic-polycytidylic acid--effects-;
KW  - Interferon inducers--polyinosinic-polycytidylic acid--lack, effects, and tumor regression, cancer patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Bhat, M Ishwara
T1  - Sources and channels of pre-investment information: requirments of small scale industries
JO  - Library Science with a Slant to Documentation
JF  - Library Science with a Slant to Documentation
Y1  - 1976/09//September-December 1976
VL  - 13
IS  - 3-4
M3  - Article
SP  - 113
EP  - 120
SN  - 00242543
AB  - Presents a short report of a pilot study carried out to identify the pre-investment information requirements, and the sources and channels used by small entrepreneurs, and also that usage of different information sources. The data were collected by direct and indirect methods, by interviews with potential entrepreneurs, new enterpreneurs, established entrepreneurs, financing agencies and small industry promotion institutes. Comments on the findings of the study. Conclusions and recommendations are made.
N1  - Accession Number: ISTA1303839; Bhat, M Ishwara 1; Affiliations: 1 : National Institute Of Mental Health And Neurosciences, Bangalore;  Source Info: September-December 1976, Vol. 13 Issue 3-4, p113; Note: Update Code: 1300; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - NELSON, S. D.
AU  - MITCHELL, J. R.
AU  - TIMBRELL, J. A.
AU  - SNODGRASS, W. R.
AU  - CORCORAN III, G. B.
T1  - Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat.
JO  - Science
JF  - Science
Y1  - 1976/09/03/
VL  - 193
IS  - 4256
M3  - Article
SP  - 901
EP  - 903
SN  - 00368075
AB  - Acetylhydrazine, a metabolite of isoniazid, a widely used antituberculosis drug, and isopropylhydrazine, a metabolite of iproniazid, an antidepressant removed from clinical use because of high incidence of liver injury, were oxidized by cytochrome P450 enzymes in human and rat liver microsomes to highly reactive acylating and alkylating agents. Covalent binding of these metabolites to liver macromolecules paralleled hepatic cellular necrosis. The metabolites formed from these andprobably other monosubstituted hydrazines are reactive electrophiles. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003135; NELSON, S. D. 1; MITCHELL, J. R. 1; TIMBRELL, J. A. 1; SNODGRASS, W. R. 1; CORCORAN III, G. B. 1; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/ 3/1976, Vol. 193 Issue 4256, p901; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Adams, E.;
AU  - Decker, D. G.;
AU  - Herbst, A. L.;
AU  - Noller, K. L.;
AU  - Tilley, B. C.;
AU  - \ET/;
T1  - Exposure in utero to diethylstilbestrol and related synthetic hormones: association with vaginal and cervical cancers and other abnormalities
CT  - Exposure in utero to diethylstilbestrol and related synthetic hormones: association with vaginal and cervical cancers and other abnormalities
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1976/09/06/
VL  - 236
IS  - Sep 6
SP  - 1107
EP  - 1109
AD  - Van Nevel, J. P., Office of Cancer Communications, National Cancer Institute, N.I.H., Bethesda, Maryland 20014
N1  - Accession Number: 14-0044; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; Publication Type: Professional and Public Relations Committee of the DESAD (Diethylstilbestrol and Adenosis) Project of the Division of Cancer Control and Rehabilitation; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2  - The National Cancer Institute supported study of vaginal cancer and other noncancerous genital tract irregularities in offspring of mothers who received synthetic estrogens (including diethylstilbestrol) during pregnancy is discussed.
KW  - Diethylstilbestrol--toxicity-;
KW  - Toxicity--diethylstilbestrol--studies, vaginal cancer following exposure in utero, humans;
KW  - Estrogens--toxicity--studies, vaginal cancer following exposure in utero, humans;
KW  - Toxicity--estrogens--studies, vaginal cancer following exposure in utero, humans;
KW  - Placental transfer--diethylstilbestrol--toxicity, studies, vaginal cancer following exposure in utero, humans;
KW  - Placental transfer--estrogens--toxicity, studies, vaginal cancer following exposure in utero, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MORGAN, DORIS ANNE
AU  - RUSCETTI, FRANCIS W.
AU  - GALLO, ROBERT
T1  - Selective in vitro Growth of T Lymphocytes from Normal Human Bone Marrows.
JO  - Science
JF  - Science
Y1  - 1976/09/10/
VL  - 193
IS  - 4257
M3  - Article
SP  - 1007
EP  - 1008
SN  - 00368075
AB  - Selective growth of T lymphocytes occurred when unfractionated normal human bone marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-stimulated normal human lymphocytes (Ly-CM). Cultures of up to 90 percent T cells have been maintained for more than 9 months. The T cells exhibited a strict growth dependence upon Ly-CM and were consistently negative for Epstein-Barr viral information. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85217986; MORGAN, DORIS ANNE 1; RUSCETTI, FRANCIS W. 1; GALLO, ROBERT 2; Affiliations: 1: Litton Bionetics Research Laboratories, Bethesda, Maryland 20014; 2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/10/1976, Vol. 193 Issue 4257, p1007; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEIGHT, FORREST F.
AU  - ERULKAR, S. D.
T1  - Modulation of Synaptic Transmitter Release by Repetitive Postsynaptic Action Potentials.
JO  - Science
JF  - Science
Y1  - 1976/09/10/
VL  - 193
IS  - 4257
M3  - Article
SP  - 1023
EP  - 1025
SN  - 00368075
AB  - The effect of repetitive action potentials in the postsynaptic axon on therelease of synaptic transmitter from the presynaptic terminal was investigated at the squid giant synapse. Repetitive antidromic stimulation of the postsynaptic axon resulted in a reduction in the excitatory postsynaptic potential (EPSP). The reduction in transmitter release was accompanied by a decrease in the presynaptic spike after hyperpolarization (AH). Increasing the concentration of extracellular potassium ions also reduced the EPSP and decreased the amplitude of the presynaptic spike AH. The reduction in transmitter release resulting from repetitive postsynaptic impulses is attributed to the accumulation of extracellular potassium ions. It is proposed that the accumulation of extracellular potassium ions resulting from repetitive postsynaptic activity may modulate synaptic transmission and function as an integrative mechanism in the nervous system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85217994; WEIGHT, FORREST F. 1; ERULKAR, S. D. 1,2; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19174; Issue Info: 9/10/1976, Vol. 193 Issue 4257, p1023; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GWADZ, ROBERT W.
T1  - Malaria: Successful Immunization Against the Sexual Stages of Plasmodium gallinaceum.
JO  - Science
JF  - Science
Y1  - 1976/09/17/
VL  - 193
IS  - 4258
M3  - Article
SP  - 1150
EP  - 1151
SN  - 00368075
AB  - Gametocyte infectivity and oocyst development of the avian malaria parasite, Plasmodium gallinaceum, can be reduced or eliminated in mosquitoes by immunizing the chickens on which the mosquitoes feed with infected red blood cells that have been treated with formalin or x-rays. Protection of the mosquito appears to be related to the immobilization of the microgametes in its gut and is associated with the immunoglobulin G fraction of serum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218038; GWADZ, ROBERT W. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/17/1976, Vol. 193 Issue 4258, p1150; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FREDRICKSON, DONALD S.
T1  - Recombinant DNA Guidelines: Environmental Impact Statement.
JO  - Science
JF  - Science
Y1  - 1976/09/24/
VL  - 193
IS  - 4259
M3  - Article
SP  - 1196
EP  - 1196
SN  - 00368075
N1  - Accession Number: 85218043; FREDRICKSON, DONALD S. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland, 20014; Issue Info: 9/24/1976, Vol. 193 Issue 4259, preceding p1196; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schein, P. S.;
AU  - DeVita V. T.;
AU  - Hubbard, S.;
AU  - Chabner, B. A.;
AU  - Canellos, G. P.;
AU  - \ET/;
T1  - Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma
CT  - Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/10/01/
VL  - 85
IS  - Oct
SP  - 417
EP  - 422
SN  - 00034819
AD  - Reprints: Div. of Medical Oncology, Georgetown Univ. Hospital, Room 2230, 3800 Reservoir Rd., Northwest, Washington, D.C. 20007
AD  - Medicine Branch and Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 14-2294; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Cyclophosphamide--6055-19-2 Doxorubicin--23214-92-8 Vincristine--57-22-7 Bleomycin--11056-06-7 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents bleomycin (10:00); AHFS Class: Antineoplastic agents prednisone; References: 22; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Robert J. Cersosimo
N2  - Thirty-six adult patients with stages II-IV diffuse histiocytic lymphoma or diffuse mixed histiocytic-lymphocytic lymphoma were treated with 6 monthly cycles consisting of a myelosuppressive phase in which 650 mg/sq m of cyclophosphamide, 25 mg/sq m of Adriamycin (doxorubicin), and 1.4 mg/sq m of vincristine were administered IV on days one and 8 and a nonmyelosuppressive phase in which 5-15 u/sq m of IV bleomycin were administered on days 15 and 22 and 60 mg/sq m of oral prednisone were administered on days 15-29. Twenty-five patients were previously untreated, 11 other patients had relapsed after radiation or combination chemotherapy. Patients were re-staged one month after completing therapy. Twelve of the 25 previously untreated patients (48%) achieved complete remission and had not relapsed for 5-30 months after completion of therapy. There were 9 partial remissions and 4 nonresponders in the previously untreated group. Three of 11 previously treated patients achieved complete remission, 2 of whom relapsed within 4 months of completion of therapy. There were 5 partial remissions in the previously treated group. It was concluded that the complete remission rate and expected survival approached that achieved in Hodgkin's disease treated with intensive combination chemotherapy and that larger comparative studies are needed.
KW  - Cyclophosphamide--bleomycin, doxorubicin, prednisone and vincristine-;
KW  - Doxorubicin--bleomycin, cyclophosphamide, prednisone and vincristine-;
KW  - Vincristine--bleomycin, cyclophosphamide, doxorubicin and prednisone-;
KW  - Bleomycin--cyclophosphamide, doxorubicin, prednisone and vincristine-;
KW  - Prednisone--bleomycin, cyclophosphamide, doxorubicin and vincristine-;
KW  - Combined therapy--antineoplastic agents--lymphomas, patients;
KW  - Antineoplastic agents--cyclophosphamide--combined therapy, lymphomas, patients;
KW  - Antineoplastic agents--doxorubicin--combined therapy, lymphomas, patients;
KW  - Antineoplastic agents--vincristine--combined therapy, lymphomas, patients;
KW  - Antineoplastic agents--bleomycin--combined therapy, lymphomas, patients;
KW  - Antineoplastic agents--prednisone--combined therapy, lymphomas, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Janossy, G.
AU  - De La Concha, E. Gomez
AU  - Waxdal, M. J.
AU  - Platts-Mills, T.
T1  - The effects of purified mitogenic proteins (Pa-1 and Pa-2) from pokeweed on human T and B lymphocytes in vitro.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/10//
VL  - 26
IS  - 1
M3  - Article
SP  - 108
EP  - 117
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Purified proteins (Pa-1 and Pa-2) from pokeweed have been compared with commercial pokeweed mitogen (PWM-G) and other mitogens in their ability to stimulate human lymphocytes. With cultures of T and B cells separated from tonsil lymphocytes, thymidine uptake, blast transformation and immunnglobulin (Ig) synthesis have been measured. IgM and IgG was measured in supernates of stimulated cultures by radioimmunoassay. Pa-1, Pa-2 and PWM-G were found to be potent mitogens for unseparated tonsil lymphocytes or nylon column purified T cells. Pa-2 was found to be active at lower concentrations than Pa-1. and PWM-G was less potent than the purified mitogens. These three mitogens all stimulated unseparated lymphocytes to secrete large quantities of Ig (20-100μg/ml) during 7 days in culture. With increasing amounts of mitogens severe decreases in immunoglobulin synthesis were observed at day 6 even with doses which were still optimal for stimulation of thymidine uptake at days 3 and 6. With purified B cells (<2% T cells) Pa-1 was the best mitogen for thymidine incorporation. However, the secretory response was very variable. In some experiments H ceils did not secrete Ig in response to mitogens, in others Pa-1 was clearly more; effective at stimulating secretion than Pa-2 or PWM-G and in some experiments B cells were stimulated by all three. In one experiment Pa-1 stimulated prolymphocytic leukaemia cells to blast transformation and the secretion of IgM. It is concluded that Pa-1, Pa-2 anti PWM-G are much better activators of Ig synthesis in human cultures than either PHA or LPS and that Pa-1 is the most reliable B-cell stimulant of the three. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - LEUCOCYTES
KW  - B cells
KW  - BIOLOGICAL transport
KW  - IMMUNOGLOBULIN G
KW  - LECTINS
N1  - Accession Number: 16017732; Janossy, G. 1 De La Concha, E. Gomez 2 Waxdal, M. J. 3 Platts-Mills, T. 2; Affiliation:  1: Imperial Cancer Research Fund, Tumour Immunology Unit, University College, London.  2: Division of Immunology, Clinical Research Centre, Harrow, Middlesex.  3: National Institute of Arthritis and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct1976, Vol. 26 Issue 1, p108; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: B cells; Subject Term: BIOLOGICAL transport; Subject Term: IMMUNOGLOBULIN G; Subject Term: LECTINS; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - 
AU  - Lystad, Mary1
T1  - Over 200 Years of American Children's Literature.
JO  - Education Digest
JF  - Education Digest
J1  - Education Digest
PY  - 1976/10//
Y1  - 1976/10//
VL  - 42
IS  - 2
CP  - 2
M3  - Article
SP  - 36
EP  - 39
SN  - 0013127X
AB  - The article discusses that children's books reflect the attitudes and values of the society. Through children's books one can see the hopes and concerns the U.S. society holds for its young and for its own future. By 1850, soul-saving didacticism was giving way to interest in the family. Around 1920 a strong interest in children as children began to appear in literature for the young. Humanistic concern for the child's own dignity prompted efforts to satisfy his needs and desires. Social problems are now also handled openly in children's literature. Problems of divorce, death, mental retardation, mental illness, senility, race, poverty, crime, drug addiction, and alcoholism are becoming the subjects of novels for young people. In the next century, interest in the child as a being will very likely continue, with interest in individual differences among children increasing as pressure for social change mounts from women and minorities. Such eventualities will be reinforced by child development specialists and by educators, who advocate more meaningful reading fare so children will be inclined to learn to read and to learn to interact with their society.
KW  - Children's literature
KW  - Reading -- Social aspects
KW  - Child development
KW  - Humanistic writing
KW  - Social problems
KW  - Social change
KW  - Educators
KW  - United States
N1  - Accession Number: 18831038; Authors: Lystad, Mary 1; Affiliations:  1: Special Assistant to the Director, Division of Special Mental Health Programs, National Institute of Mental Health, Rockville, Maryland.; Subject: Children's literature; Subject: Reading -- Social aspects; Subject: Child development; Subject: Humanistic writing; Subject: Social problems; Subject: Social change; Subject: Educators; Subject: United States; Number of Pages: 4p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
AU  - Sohnle, Peter G.
AU  - Kirkpatrick, Charles H.
T1  - Deposition of Complement in the Lesions of Experimental Cutaneous Candidiasis in Guinea Pigs.
JO  - Journal of Cutaneous Pathology
JF  - Journal of Cutaneous Pathology
Y1  - 1976/10//
VL  - 3
IS  - 5
M3  - Article
SP  - 323
EP  - 238
SN  - 03036987
AB  - Deposits of C3 have been demonstrated at the dermo-epidermal junction in the lesions of experimental cutaneous candidiasis in guinea pigs. The deposits were granular in character and similar to those previously found in the lesions of chronic mucocutaneous candidiasis in humans. Immunoglobulin, C4 and candida antigen were not detected in the lesions. C3 was also found in a similar pattern at the dermo-epidermal junction of candida-infected skin from homozygous C4-deficient guinea pigs. From these observations, it is postulated that complement deposition occurs in these lesions as a result of alternative pathway activation, perhaps by cell wall components from the infecting organisms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUINEA pigs
KW  - CAVIIDAE
KW  - CANDIDIASIS
KW  - MYCOSES
KW  - IMMUNOGLOBULINS
KW  - EPIDERMIS
N1  - Accession Number: 11814759; Sohnle, Peter G. 1 Kirkpatrick, Charles H. 1; Affiliation:  1: Laboratory of Clinical Investigation, National institute of Allergy and Infectious Diseases, Bethesda, MD 20014 U.S.A.; Source Info: 1976, Vol. 3 Issue 5, p323; Subject Term: GUINEA pigs; Subject Term: CAVIIDAE; Subject Term: CANDIDIASIS; Subject Term: MYCOSES; Subject Term: IMMUNOGLOBULINS; Subject Term: EPIDERMIS; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1600-0560.ep11814759
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - RPRT
AU  - Yaoita, Hideo
AU  - Katz, Stephen I.
T1  - IMMUNOELECTRONMICROSCOPIC LOCALIZATION OF IgA IN SKIN OF PATIENTS WITH DERMATITIS HERPETIFORMIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/10//
VL  - 67
IS  - 4
M3  - Report
SP  - 502
EP  - 506
SN  - 0022202X
AB  - Ultrastructural localization of in vivo-bound IgA in the skin of patients with dermatitis herpetiformis was determined by using a modified peroxidase-antiperoxidase multistep method. Three types of reaction product deposition are seen. The most common type of reaction product deposition, that which is identified by direct immunofluorescence as the speckled type of IgA deposit, shows up as clumps and yarnlike fibrils. The second type of IgA deposition, which is a linear band by direct immunofluorescence, appears to be associated with anchoring fibrils. The third type of IgA deposition, which is also linear by immuno- fluorescence, is confined to the lamina lucida. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DERMATITIS herpetiformis
KW  - IMMUNOGLOBULIN A
KW  - DERMATOLOGY
KW  - IMMUNOFLUORESCENCE
KW  - IMMUNOGLOBULINS
KW  - FLUORESCENCE
KW  - IMMUNOLOGY -- Technique
N1  - Accession Number: 12664534; Yaoita, Hideo 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S. A..; Source Info: Oct76, Vol. 67 Issue 4, p502; Subject Term: DERMATITIS herpetiformis; Subject Term: IMMUNOGLOBULIN A; Subject Term: DERMATOLOGY; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNOGLOBULINS; Subject Term: FLUORESCENCE; Subject Term: IMMUNOLOGY -- Technique; Number of Pages: 5p; Document Type: Report
L3  - 10.1111/1523-1747.ep12664534
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Silbergeld, Sam
AU  - Koenig, Gail R.
AU  - Manderscheid, Ronald W.
T1  - ASSESSMENT OF THE PSYCHOSOCIAL ENVIRONMENT OF THE CLASSROOM: THE CLASS ATMOSPHERE SCALE.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1976/10//
VL  - 100
IS  - 1
M3  - Article
SP  - 65
PB  - Taylor & Francis Ltd
SN  - 00224545
N1  - Accession Number: 5393754; Silbergeld, Sam 1,2 Koenig, Gail R. 1,2 Manderscheid, Ronald W. 1,2; Affiliation:  1: National Institute of Mental Health, University of Maryland.  2: Department of Sociology, University of Maryland.; Source Info: Oct1976, Vol. 100 Issue 1, p65; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeVita, V. T.;
AU  - Kershner, L. M.;
T1  - Adjuvant chemotherapy with anticancer drugs
CT  - Adjuvant chemotherapy with anticancer drugs
JO  - Pharmacy Times (USA)
JF  - Pharmacy Times (USA)
Y1  - 1976/10/01/
VL  - 42
IS  - Oct
SP  - 58
EP  - 63
SN  - 00030627
AD  - National Cancer Institute, NIH, Bethesda, Maryland
N1  - Accession Number: 14-2061; Language: English; Trade Name: L-Phenylalanine mustard--Cytoxan; Generic Name: Melphalan; Cyclophosphamide; Chemical Name: Melphalan--148-82-3 Cyclophosphamide--6055-19-2 Fluorouracil--51-21-8 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents melphalan (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents fluorouracil; Journal Coden: PYTMAO; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Walter F. Stanaszek
N2  - The role of anticancer drugs in treatment of solid tumors is discussed as they are currently being employed in adjuvant chemotherapy, i.e., soon after surgery to attack micrometastases undetectable by current diagnostic techniques. Studies are reported in which L-phenylalanine mustard (melphalan) and a combination of Cytoxan (cyclophosphamide), methotrexate and fluorouracil both showed a statistically significant difference as compared to controls in length of disease free interval. Specific regimens for studies in patients with breast cancer and osteogenic sarcoma are outlined, as are criteria for adjuvant chemotherapy trials.
KW  - Melphalan--tumors-;
KW  - Cyclophosphamide--fluorouracil and methotrexate-;
KW  - Fluorouracil--cyclophosphamide and methotrexate-;
KW  - Methotrexate--cyclophosphamide and fluorouracil-;
KW  - Antineoplastic agents--melphalan--tumors, solid, therapy, discussion;
KW  - Antineoplastic agents--cyclophosphamide--combined therapy, solid tumors, discussion;
KW  - Antineoplastic agents--methotrexate--combined therapy, solid tumors, discussion;
KW  - Antineoplastic agents--fluorouracil--combined therapy, solid tumors, discussion;
KW  - Combined therapy--antineoplastic agents--tumors, solid, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
T1  - LOOKING BACK-A 2-YEAR REVIEW AND APPRAISAL OF SOCIAL PROBLEMS RESEARCH.
JO  - Social Problems
JF  - Social Problems
Y1  - 1976/10//
VL  - 24
IS  - 1
M3  - Article
SP  - 94
SN  - 00377791
AB  - Research in the area of social problems, covering 1950-75, needs further methodological refinement and the psychological impact of social structure, cross-national research, social and individual change, and intersocial interaction need exploration.
KW  - SOCIAL problems
KW  - SOCIOLOGICAL research
KW  - SOCIAL structure
KW  - SOCIAL change
KW  - SOCIAL movements
KW  - APPLIED sociology
KW  - HISTORICAL research
N1  - Accession Number: 4837585; Kohn, Melvin L. 1; Affiliations: 1 : National Institute of Mental Health.;  Source Info: Oct76, Vol. 24 Issue 1, p94; Historical Period: 1950 to 1975; Subject Term: SOCIAL problems; Subject Term: SOCIOLOGICAL research; Subject Term: SOCIAL structure; Subject Term: SOCIAL change; Subject Term: SOCIAL movements; Subject Term: APPLIED sociology; Subject Term: HISTORICAL research; Number of Pages: 19p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
ID  - 2013-42022-019
AN  - 2013-42022-019
AU  - Shore, Milton F.
T1  - Review of The uses of enchantment: The meaning and importance of fairy tales.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1976/10//
VL  - 46
IS  - 4
SP  - 727
EP  - 728
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42022-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Fantasy; Folklore. Minor Descriptor: Violence. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). Reviewed Item: Bettelheim, Bruno. The uses of enchantment: The meaning and importance of fairy tales=328 pp. $12.50. Knopf, New York; 1976. Page Count: 2. Issue Publication Date: Oct, 1976. 
AB  - Reviews the book, The Uses of Enchantment: The Meaning and Importance of Fairy Tales by Bruno Bettelheim (1976). The author pleads for greater recognition and use of fairy tales as symbolic forms, important and necessary for the adequate resolution of certain developmental issues. The author defends fairy tales against all critics, even accepting the primitive violence in many tales by the Grimms as merely reflecting the intense hostility that permeates the fantasy life of the preschool child. The book has two sections. The first describes vividly the power of magic in the fantasy of the young child and the general content areas, processes, and principles that are played out in fairy tales. The second is a detailed analysis of such well-known fairy tales as Snow White and Cinderella. The book does not dwell on the historical, literary, or educational aspects of fairy tales. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - enchantment
KW  - fairy tales
KW  - childhood development
KW  - primitive violence
KW  - fantasy
KW  - 1976
KW  - Childhood Development
KW  - Fantasy
KW  - Folklore
KW  - Violence
KW  - 1976
U2  - Bettelheim, Bruno. (1976); The uses of enchantment: The meaning and importance of fairy tales; 328 pp. $12.50. Knopf, New York
DO  - 10.1037/h0098760
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - FAMIGLIETTI JR., E. V.
AU  - KOLB, HELGA
T1  - Structural Basis for ON- and OFF-Center Responses in Retinal Ganglion Cells.
JO  - Science
JF  - Science
Y1  - 1976/10/08/
VL  - 194
IS  - 4261
M3  - Article
SP  - 193
EP  - 195
SN  - 00368075
AB  - The inner plexiform layer of the mammalian retina has a bisublaminar organization determined by restricted branching of the terminals of cone bipolar cells and dendrites of class I (large) and class II (small) ganglion cells. Comparison of dendritic field diameters and receptive field center sizes of large ganglion cells suggests that neural circuitry in sublamina a conveys "OFF"-center properties and connections in sublamina b "ON"-center properties to retinal ganglion cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218162; FAMIGLIETTI JR., E. V. 1; KOLB, HELGA 2; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20014; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda; Issue Info: 10/ 8/1976, Vol. 194 Issue 4261, p193; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Hoff, D. D.;
AU  - Rozencweig, M.;
AU  - Slavik, M.;
AU  - Muggia, F. M.;
T1  - Activity of daunomycin in solid tumors
CT  - Activity of daunomycin in solid tumors
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1976/10/11/
VL  - 236
IS  - Oct 11
SP  - 1693
AD  - National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 14-0693; Language: English; Trade Name: Daunomycin; Generic Name: Daunorubicin; Chemical Name: Daunorubicin--20830-81-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin; References: 3; Publication Type: Letters; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2  - It was stated that there is an inadequate amount of information presently available to confirm whether daunomycin (daunorubicin) is active or inactive in treating solid tumors in humans.
KW  - Daunorubicin--tumors-;
KW  - Rational therapy--daunorubicin--tumors, solid, lack of adequate information, patients;
KW  - Antineoplastic agents--daunorubicin--tumors, solid, rational therapy, lack of adequate information, patients;
KW  - Drug information--daunorubicin--lack, rational therapy of solid tumors, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - PERT, CANDACE B.
AU  - PERT, AGU
AU  - CHANG, JAW-KANG
AU  - FONG, Bosco T. W.
T1  - [D-Ala²]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic.
JO  - Science
JF  - Science
Y1  - 1976/10/15/
VL  - 194
IS  - 4262
M3  - Article
SP  - 330
EP  - 332
SN  - 00368075
AB  - [D-Ala²]-Met-enkephalinamide (DALA), a synthetic enkephalin analog designed by in vitro analysis, binds to opiate receptors almost as tightly as methionine- enkephalin. Since it is not susceptible to degradation by brain enzymes, low doses (5 to 10 micrograms) cause profound, long-lasting, morphine-like analgesia when microinjected into rat brain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218204; PERT, CANDACE B. 1; PERT, AGU 1; CHANG, JAW-KANG 2; FONG, Bosco T. W. 2; Affiliations: 1: Section on Biochemistry, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Bioproducts Department, Beckman Instruments, Inc., Palo Alto, California 94304; Issue Info: 10/15/1976, Vol. 194 Issue 4262, p330; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BUCHSBAUM, MONTE S.
AU  - COURSEY, ROBERT D.
AU  - MURPHY, DENNIS L.
T1  - The Biochemical High-Risk Paradigm: Behavioral and Familial Correlates of Low Platelet Monoamine Oxidase Activity.
JO  - Science
JF  - Science
Y1  - 1976/10/15/
VL  - 194
IS  - 4262
M3  - Article
SP  - 339
EP  - 341
SN  - 00368075
AB  - A population of individuals potentially at risk for psychiatric disorders was identified by screening 375 college student volunteers for low platelet monoamine oxidase (MAO) activity levels. The lower and upper 10 percent in MAO activity were interviewed and family history data were obtained. Low-MAO probands reported more frequent psychiatric or psychological counseling and problems with the law. Families of low-MAO probands had an eightfold increase in the incidence of suicide or suicide attempts over those of high-MAO probands. This suggests that reduced MAO levels, reported previously in patients with affective disorders and chronic schizophrenia, may predict a vulnerability to psychiatric disorder. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85218209; BUCHSBAUM, MONTE S. 1; COURSEY, ROBERT D. 2; MURPHY, DENNIS L. 3; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20016; 2: Department of Psychology, University of Maryland, College Park 20740; 3: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 10/15/1976, Vol. 194 Issue 4262, p339; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
TY  - GEN
AU  - Licata, A. A.;
AU  - Bartter, F. C.;
T1  - Spironolactone induced gynecomastia related to allergic reaction to Darvon Compound
CT  - Spironolactone induced gynecomastia related to allergic reaction to Darvon Compound
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/10/23/
VL  - 2
IS  - Oct 23
SP  - 905
SN  - 00237507
AD  - Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-1061; Language: English; Trade Name: Darvon Compound-65; Generic Name: Aspirin; Chemical Name: Spironolactone--52-01-7 Aspirin--50-78-2 Caffeine--58-08-2 Phenacetin--62-44-2 Propoxyphene hydrochloride--1639-60-7; Therapeutic Class: (40:28); AHFS Class: Diuretics spironolactone; References: 5; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Joan Lentine
N2  - Reported is an episode of transient gynecomastia in a 58-yr-old white man which developed 4 yr after treatment with spironolactone had been started and was temporally related to an allergic reaction provoked by the analgesic Darvon Compound-65 (aspirin 230 mg, caffeine 30 mg, phenacetin 150 mg and propoxyphene hydrochloride 65 mg; I). It is unusual for spironolactone to produce gynecomastia for the first time after many yr of use. The allergic reaction to I was considered a precipitating cause. Although this patient had previously taken propoxyphene HCl without an allergic reaction, it is not certain which of the other components in I is responsible for the allergy. Because the patient developed symptoms similar to those of his original reaction when he was challenged with I while he was taking spironolactone, there does seem to be a relation. Whether I specifically or the allergic reaction it provoked increased the sensitivity to spironolactone is uncertain.
KW  - Spironolactone--interactions-;
KW  - Aspirin--combination, caffeine, phenacetin, propoxyphene hydrochloride-;
KW  - Caffeine--combination, aspirin, phenacetin, propoxyphene hydrochloride-;
KW  - Phenacetin--combination, aspirin, caffeine, propoxyphene hydrochloride-;
KW  - Propoxyphene hydrochloride--combination, aspirin, caffeine, phenacetin-;
KW  - Drug interactions--spironolactone and aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride--gynecomastia, transient, patient;
KW  - Drug interactions--aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride and spironolactone--gynecomastia, transient, patient;
KW  - Diuretics--spironolactone--interactions, aspirin, combination, caffeine, phenacetin, propoxyphene, transient gynecomastia, patient;
KW  - Drugs, adverse reactions--spironolactone and aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride--gynecomastia, transient, patient;
KW  - Drugs, adverse reactions--aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride and spironolactone--gynecomastia, transient, patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - PALMER, LAWRENCE G.
AU  - GULATI, JAGDISH
T1  - Potassium Accumulation in Muscle: A Test of the Binding Hypothesis.
JO  - Science
JF  - Science
Y1  - 1976/10/29/
VL  - 194
IS  - 4264
M3  - Article
SP  - 521
EP  - 523
SN  - 00368075
AB  - Livingfrog skeletal muscle can accumulate potassium in vitro to concentrations up to 580 millimolar. Both the amount of potassium accumulated and the relationship between intracellular and extracellular potassium concentrations indicate that potassium is "free" under all conditions, rather than bound to cellular macromolecules. The data also indicate that at most 20 percent of the cell water is "bound" in the sense that it excludes electrolytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436999; PALMER, LAWRENCE G. 1; GULATI, JAGDISH 2; Affiliations: 1: Department of Physiology, University of Pennsylvania, Philadelphia 19174; 2: Laboratory of Physical Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/29/1976, Vol. 194 Issue 4264, p521; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - MARTIN, W. J.
AU  - GIPSON, T. G.
AU  - MARTIN, S. E.
AU  - RICE, J. M.
T1  - Derepressed Alloantigen on Transplacentally Induced Lung Tumor Coded for by H-2 Linked Gene.
JO  - Science
JF  - Science
Y1  - 1976/10/29/
VL  - 194
IS  - 4264
M3  - Article
SP  - 532
EP  - 533
SN  - 00368075
AB  - A transplacentally induced lung tumor of strain C3Hf mice grows progressively when transplanted to (C3Hf x A)F1 hybrid mice but not when transplanted to C3Hf recipients. Progressive tumor growth occurs in [(C3Hf x A)F1 x C3Hfl backcross mice inheriting the H-2a haplotype from the F1 parent. Furthermore, radioresistant immunity to the lung tumor can be induced in C3Hf mice by immunization with normal tissue of B1O.A and BIO.A(2R) but not of BJO or BIO.A(5R) strain mice. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87436993; MARTIN, W. J. 1; GIPSON, T. G. 1; MARTIN, S. E. 2; RICE, J. M. 3; Affiliations: 1: Division of Virology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014; 2: Laboratory of Biochemical Genetics, National Heart and Lung Institute, Bethesda, Maryland 20014; 3: Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/29/1976, Vol. 194 Issue 4264, p532; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
TY  - GEN
AU  - Loriaux, D. L.;
AU  - Menard, R.;
AU  - Taylor, A.;
AU  - Pita, J. C.;
AU  - Santen, R.;
T1  - Spironolactone and endocrine dysfunction
CT  - Spironolactone and endocrine dysfunction
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/11/01/
VL  - 85
IS  - Nov
SP  - 630
EP  - 636
SN  - 00034819
AD  - Endocrinology Service Unit, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-5534; Language: English; Chemical Name: Spironolactone--52-01-7; Therapeutic Class: (40:28); AHFS Class: Diuretics spironolactone; References: 39; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology
N2  - This conference presents a discussion of how differing mechanisms might interact to produce the endocrine side effects associated with spironolactone therapy. Therapy with spironolactone is often associated with estrogen-like side effects, including impotence and gynecomastia in men and menstrual irregularity in women. Several possible mechanisms by which spironolactone could cause these side effects have been identified. Spironolactone has been shown to affect both gonadal and adrenal steroidogenesis, to elevate plasma gonadotropin levels in children, and to act as an antiandrogen at the target tissue level. Although the exact mechanism by which spironolactone causes its unpleasant side effects remains unidentified, its effects on steroid biosynthesis and androgen action have been described.
KW  - Spironolactone--toxicity-;
KW  - Diuretics--spironolactone--toxicity, mechanism of action, endocrine side effects;
KW  - Mechanism of action--spironolactone--side effects, endocrine, review;
KW  - Toxicity--spironolactone--mechanism of action, endocrine side effects;
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ER  - 

TY  - JOUR
AU  - Glinski, W.
AU  - Gershwin, M. E.
AU  - Budman, D. R.
AU  - Steinberg, A. D.
T1  - Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/11//
VL  - 26
IS  - 2
M3  - Article
SP  - 228
EP  - 238
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Peripheral blood lymphocytes of thirty normal volunteers and fifty-two patients with systemic lupus erythematosus were fractionated using a discontinuous (5-30%) Ficoll gradient. Such fractionation permitted the isolation, identification and study of null cells, T cells and B cells. Patients with inactive SLE were found to have a cell distribution and responsiveness to PHA, Con A and Pokeweed mitogen (PWM) similar to controls. In contrast, patients with active SLE showed a significant decrease in T-cell fractions as well as a relative increase in null cells, a normal distribution of B cells, a marked reduction in responsiveness to Con A, a lesser reduction to PHA and only a minor reduction to PWM. With increasing disease activity, the number of null cells increased despite lymphopenia. Spontaneous lymphocyte transformation was observed in patients with SLE. This occurred predominantly in the fractions enriched in B cells and was observed both early (0-16 hr) and late (68-72 hi) in the lymphocyte cultures. The method of discontinuous Ficoll gradients is both versatile and reproducible with good correlations between isolated lymphoid suhpopulations and disease activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SYSTEMIC lupus erythematosus
KW  - AUTOIMMUNE diseases
KW  - LYMPHOCYTES
KW  - CELL fractionation
KW  - FICOLL
KW  - DENSITY gradient centrifugation
KW  - POKEWEED mitogens
KW  - IMMUNOCYTOCHEMISTRY
N1  - Accession Number: 15946755; Glinski, W. 1,2 Gershwin, M. E. 1,2 Budman, D. R. 1,2 Steinberg, A. D. 1,2; Affiliation:  1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland.  2: The Section of Rheumatology-Clinical Immunology, School of Medicine, University of California, California, U.S.A.; Source Info: Nov1976, Vol. 26 Issue 2, p228; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: AUTOIMMUNE diseases; Subject Term: LYMPHOCYTES; Subject Term: CELL fractionation; Subject Term: FICOLL; Subject Term: DENSITY gradient centrifugation; Subject Term: POKEWEED mitogens; Subject Term: IMMUNOCYTOCHEMISTRY; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Takeichi, Noritoshi
AU  - Boone, C. W.
AU  - Klein, E.
T1  - Local adoptive transfer to mice of human delayed hypersensitivity.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1976/11//
VL  - 26
IS  - 2
M3  - Article
SP  - 310
EP  - 313
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Human delayed hypersensitivity to living BCG organisms and/or Varidase was adoptively transferred to mice and assayed in mice by a radioisotope footpad assay (FPA). A mixture of the antigen and peripheral blood lymphocytes from patients (positive skin reactions to PPD and/or Varidase) or healthy volunteers was inoculated into the footpads of lethally X-irradiated mice. A positive footpad reaction was accompanied by an increased leakage of the radiolabelled serum protein from the blood stream into the intercellular space at the site of inoculation, and was measured by the `foot-count ratio', or radioactivity in the test foot divided by radioactivity in the contralateral foot. The intensity of the footpad reaction correlated directly with the skin test response of the human lymphocyte donors. [ABSTRACT FROM AUTHOR]
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KW  - DELAYED hypersensitivity
KW  - CELLULAR immunity
KW  - BCG vaccination
KW  - LYMPHOCYTES
KW  - RADIOISOTOPES -- Therapeutic use
KW  - BLOOD donors
KW  - SKIN tests
N1  - Accession Number: 15947133; Takeichi, Noritoshi 1 Boone, C. W. 1 Klein, E. 2; Affiliation:  1: Cell Biology Section, Laboratory of Viral Carcinogenesis, Viral Oncology Program, National Cancer Institute, U.S. Department of Health, Education and Welfare, Bethesda, Maryland.  2: Department of Dermatology, Roswell Park Memorial Institute, Buffalo, N. Y., U.S.A.; Source Info: Nov1976, Vol. 26 Issue 2, p310; Subject Term: DELAYED hypersensitivity; Subject Term: CELLULAR immunity; Subject Term: BCG vaccination; Subject Term: LYMPHOCYTES; Subject Term: RADIOISOTOPES -- Therapeutic use; Subject Term: BLOOD donors; Subject Term: SKIN tests; Number of Pages: 4p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chang, P.;
AU  - Riggs, C. E.;
AU  - Scheerer, M. T.;
AU  - Wiernik, P. H.;
AU  - Bachur, N. R.;
T1  - Combination chemotherapy with adriamycin and streptozotocin. 2. Clinicopharmacologic correlation of augmented adriamycin toxicity caused by streptozotocin
CT  - Combination chemotherapy with adriamycin and streptozotocin. 2. Clinicopharmacologic correlation of augmented adriamycin toxicity caused by streptozotocin
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1976/11/01/
VL  - 20
IS  - Nov
SP  - 611
EP  - 616
SN  - 00099236
AD  - Sections of Medical Oncology and Biochemistry, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1  - Accession Number: 14-5045; Language: English; Trade Name: Adriamycin--Streptozotocin; Generic Name: Doxorubicin; Streptozocin; Chemical Name: Doxorubicin--23214-92-8 Streptozocin--18883-66-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents streptozocin; References: 17; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Interactions
N2  - Plasma pharmacokinetics were compared in patients with advanced sarcomas receiving adriamycin (doxorubicin; I), 60 mg/sq m, IV on day one every 3 weeks in combination with streptozotocin (streptozocin; II), 500 mg/sq m/day IV on days one to 5 every 3 weeks, and patients receiving I alone in the same dose and schedule. The combination treated group had greater I drug exposure (concentration \X/ time) when serial plasma levels were analyzed by fluorescence assay and by radioimmunoassay. The plasma half-life of I equivalents measured by fluorescence assay was also significantly prolonged in the combination treated group. These changes correlated well with an increase in I related toxicity\M/mucositis and myelosuppression\M/seen in the patients who received the combination drug therapy. Plasma II kinetics and the incidence of II related side effects\M/hepatic and renal function abnormalities\M/were those published for II alone. Evidence is presented to support the hypothesis that the increased incidence of I side effects is due to II related hepatic dysfunction, affecting both the detoxification and excretion of I. Combination of other drugs with I should take into account their potential for inducing hepatic dysfunction which may affect the therapeutic index of I.
KW  - Doxorubicin--interactions-;
KW  - Streptozocin--interactions-;
KW  - Drug interactions--doxorubicin and streptozocin--toxicity, hepatic, enhanced, and pharmacokinetics, advanced sarcoma patients;
KW  - Drug interactions--streptozocin and doxorubicin--toxicity, hepatic, enhanced, and pharmacokinetcs, advanced sarcoma patients;
KW  - Antineoplastic agents--doxorubicin--interactions, streptozocin, enhanced hepatic toxicity, and pharmacokinetics, advanced sarcoma patients;
KW  - Antineoplastic agents--streptozocin--interactions, doxorubicin, enhanced hepatic toxicity, and pharmacokinetics, advanced sarcoma patients;
KW  - Toxicity--doxorubicin--interactions, streptozocin, enhanced hepatic, and pharmacokinetics, advanced sarcoma patients;
KW  - Toxicity--streptozocin--interactions, doxorubicin, enhanced hepatic, and pharmacokinetics, advanced sarcoma patients;
KW  - Pharmacokinetics--doxorubicin--alone and with streptozocin, blood levels and half-life, enhanced hepatic toxicity, advanced sarcoma patients;
KW  - Pharmacokinetics--streptozocin and doxorubicin--blood levels, and half-life, enhanced hepatic toxicity, advanced sarcoma patients;
KW  - Blood levels--doxorubicin--alone and with streptozocin, relation to enhanced hepatic toxicity, advanced sarcoma patients;
KW  - Blood levels--streptozocin and doxorubicin--pharmacokinetics, relation to enhanced hepatic toxicity, advanced sarcoma patients;
KW  - Half-life--doxorubicin--alone and with streptozocin, relation to enhanced hepatic toxicity, advanced sarcoma patients;
KW  - Half-life--streptozocin and doxorubicin--pharmacokinetics, relation to enhanced hepatic toxicity, advanced sarcoma patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Grove, W. R.;
AU  - Bender, J. R.;
AU  - Fortner, C. L.;
AU  - Strauss, G.;
AU  - Wiernik, P. H.;
T1  - Benzquinamide-induced extrapyramidal reaction
CT  - Benzquinamide-induced extrapyramidal reaction
JO  - Drug Intell. Clin. Pharm.
JF  - Drug Intell. Clin. Pharm.
Y1  - 1976/11/01/
VL  - 10
IS  - Nov
SP  - 638
EP  - 639
AD  - National Cancer Institute, Baltimore Cancer Research Center at the Univ. of Maryland Hospital, Baltimore, Maryland
N1  - Accession Number: 14-2505; Language: English; Chemical Name: Benzquinamide--63-12-7 Diphenhydramine--58-73-1; Therapeutic Class: (56:22); AHFS Class: Anti-emetics benzquinamide (4:00); AHFS Class: Antihistamines diphenhydramine; References: 6; Journal Coden: DICPBB; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2  - A case report of a patient who developed an extrapyramidal reaction following the IM administration of 50 mg benzquinamide is presented. This reaction has not been previously reported. Prior to this, the patient had reacted similarly to prochlorperazine. Diphenhydramine was useful in reversing the reaction on both occasions.
KW  - Benzquinamide--adverse reactions-;
KW  - Diphenhydramine--effects-;
KW  - Drugs, adverse reactions--benzquinamide--extrapyramidal, diphenhydramine therapy, case report;
KW  - Anti-emetics--benzquinamide--adverse reactions, extrapyramidal, diphenhydramine therapy, case report;
KW  - Antihistamines--diphenhydramine--effects, extrapyramidal symptoms, benzquinamide induced, case report;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Rosseneu, Maryvonne
AU  - Soetewey, Frederick
AU  - Peeters, Hubert
AU  - Bausserman, Linda L.
AU  - Herbert, Peter N.
T1  - Interaction of the Apoproteins of Very Low Density and High Density Lipoproteins with Synthetic Phospholipids.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1976/11//Nov76 Part 1
VL  - 70
IS  - 1
M3  - Article
SP  - 285
EP  - 289
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The interaction of synthetic dimyristoyl phosphatidylcholine (lecithin) liposomes with isolated apoC-I and apoC-III proteins from very low density lipoproteins has been studied by micro- calorimetry. Complex formation is a highly exothermal process characterized by a maximal enthalpy of -130 kcal/mol (-544 kJ) apoC-III-1 and -65 kcal mol apoC-I proteins (-272 kJ). The complex composition determined after its isolation by ultracentrifugal flotation agrees with the value derived from the enthalpy binding curves. The binding of a constant amount of dimyristoyl lecithin to apoprotein mixtures containing various proportions of apoA-I and apoC-III failed to demonstrate the existence of any preferential association between the two apoproteins, in contrast with results obtained previously with apoA-I/ apoA-II protein mixtures. Finally the various contributions to the enthalpy of binding such as that arising from an increase in apoprotein helicity have been evaluated. A classification of the apolipoproteins according so their lipid-binding affinity is proposed as: apoA-II [This symbol cannot be presented in ASCII format] apoC-III > apoC-I > apoA-I proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIPOPROTEINS
KW  - PHOSPHOLIPIDS
KW  - MOLECULAR association
KW  - LECITHIN
KW  - LIPOSOMES
KW  - DENSITY
KW  - BIOCHEMISTRY
N1  - Accession Number: 13581302; Rosseneu, Maryvonne 1 Soetewey, Frederick 1 Peeters, Hubert 1 Bausserman, Linda L. 1 Herbert, Peter N. 1; Affiliation:  1: Simon Stevin Instituut voor Wetenschappelijk Onderzock, Brugge, and Section of Lipoprotein Structure, Molecular Disease Branch, National Heart & Lung Institute, National Institutes of Health, Bethesda; Source Info: Nov76 Part 1, Vol. 70 Issue 1, p285; Subject Term: LIPOPROTEINS; Subject Term: PHOSPHOLIPIDS; Subject Term: MOLECULAR association; Subject Term: LECITHIN; Subject Term: LIPOSOMES; Subject Term: DENSITY; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gail, M.;
AU  - Williams, R.;
AU  - Byar, D. P.;
AU  - Brown, C.;
T1  - How many controls?
CT  - How many controls?
JO  - J. Chronic Dis.
JF  - J. Chronic Dis.
Y1  - 1976/11/01/
VL  - 29
IS  - Nov
SP  - 723
EP  - 731
AD  - Clinical and Diagnostic Trials Section, National Cancer Institute, NIH, Landow Bldg., Rm. C-509, Bethesda, MD 20014
N1  - Accession Number: 15-1337; Language: English; References: 10; Journal Coden: JOCDAE; Section Heading: Methodology; Abstract Author: Nancy Seren
N2  - The paper discusses how many controls are needed for a study comparing responses in only 2 groups, and those situations where it is appropriate to deviate from equal allocation in fixed sample clinical trials. Given unequal allocation, randomization to assign the subject to a treatment still applies; the only change being the odds of assignment to a group become K to 1.
KW  - Clinical studies--control--need, unequal allocation;
KW  - Control--clinical studies--need, unequal allocation;
KW  - Methodology--clinical studies--need, controls;
KW  - Statistics--clinical studies--need, controls;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=15-1337&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Feldmann, R J
T1  - Quality control of chemical data bases
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1976/11//
VL  - 16
IS  - 4
M3  - Article
SP  - 232
EP  - 233
SN  - 00952338
AB  - The problems of quality control of the data in the files that comprise the epa-nih chemical information system (cis) are described and discussed. The use of the chemical abstracts registry numbers (regn) in these data bases is also described.
N1  - Accession Number: ISTA1201706; Feldmann, R J 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland;  Source Info: November 1976, Vol. 16 Issue 4, p232; Note: Update Code: 1200; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hirata, T.;
AU  - Driscoll, J. S.;
T1  - Potential CNS antitumor agents\M/phenothiazines. 1. Nitrogen mustard derivatives
CT  - Potential CNS antitumor agents\M/phenothiazines. 1. Nitrogen mustard derivatives
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1976/11/01/
VL  - 65
IS  - Nov
SP  - 1699
EP  - 1701
SN  - 00223549
AD  - Drug Design and Chemistry Section, Laboratory of Medicinal Chemistry and Biology, Drug Research and Development Program, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-1137; Language: English; References: 23; Publication Type: Notes; Journal Coden: JPMSAE; Section Heading: Preliminary Drug Testing; Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2  - Synthesis of 4 phenothiazine derivatives containing the bis(\b/-chloroethyl)aminopropyl side chain is presented. These analogs were tested against murine L-1210, P-388 and B-16 melanomas and compared to the activity of aminoethyl phenothiazine mustards. The aminoethyl derivatives were superior in all test systems.
KW  - Phenothiazines--bis(\b/-chloroethyl)aminopropyl--synthesis, and antineoplastic activity, in vitro;
KW  - Antineoplastic agents--phenothiazines--bis(\b/-chloroethyl)aminopropyl, synthesis and activity, in vitro;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06280-035
AN  - 2006-06280-035
AU  - Russo, Nancy Felipe
T1  - On the Psychology of Women: The Competition for the Market Begins.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1976/11//
VL  - 21
IS  - 11
SP  - 818
EP  - 819
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06280-035. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Russo, Nancy Felipe; Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Bethesda, MD, Iceland. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavior; Experience Level; Human Females; Psychology of Women. Minor Descriptor: Competition. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Deaux, Kay. The Behavior of Women and Men=Monterey, Calif.: Brooks/Cole, 1976. Pp. xi + 168. $4.95; 1976. Hyde, Janet Shibley; Rosenberg, B. G. Half the Human Experience: The Psychology of Women=Lexington, Mass.: Heath, 1976. Pp. xiii + 306. $4.95 paper; 1976. Page Count: 2. Issue Publication Date: Nov, 1976. 
AB  - Reviews the books, The Behavior of Women and Men by Kay Deaux (1976) and Half the Human Experience: The Psychology of Women by Janet Shibley Hyde and B. G. Rosenberg (see record [rid]1976-20603-000[/rid]). Deaux integrates a considerable number of findings from the traditional social psychological literature. The author's style is highly readable, interspersed with anecdotes that tie the laboratory to daily experience. A book that provides a broad coverage of the female experience is sorely needed, and Half the Human Experience contains a wealth of interesting information and insights. Perhaps the book's most detrimental characteristic is its treatment of biological contributions to development. The style and attractiveness are undeniably crucial to good pedagogy, the effects of such pressure are potentially beneficial. Both the are groundbreakers in a new market, and a multitude of competitors can be expected to follow. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - women psychology
KW  - human experience
KW  - women behavior
KW  - men behavior
KW  - 1976
KW  - Behavior
KW  - Experience Level
KW  - Human Females
KW  - Psychology of Women
KW  - Competition
KW  - 1976
U2  - Deaux, Kay. (1976); The Behavior of Women and Men; Monterey, Calif.: Brooks/Cole, 1976. Pp. xi + 168. $4.95
U2  - Hyde, Janet Shibley; Rosenberg, B. G. (1976); Half the Human Experience: The Psychology of Women; Lexington, Mass.: Heath, 1976. Pp. xiii + 306. $4.95 paper
DO  - 10.1037/014730
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06280-035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06280-049
AN  - 2006-06280-049
AU  - Zifferblatt, Steven M.
T1  - Chronic Pain and Illness With Patients and With Scientific Methodology.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1976/11//
VL  - 21
IS  - 11
SP  - 834
EP  - 835
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06280-049. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zifferblatt, Steven M.; NIH National Heart, Lung, and Blood Institute, Bethesda, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Chronic Illness; Chronic Pain; Experimental Methods; Social Processes. Minor Descriptor: Pain. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Reviewed Item: Fordyce, Wilbert E. Behavioral Methods for Chronic Pain and Illness=St. Louis, Mo.: Mosby, 1976. Pp. ix + 236. $9.50; 1976. Page Count: 2. Issue Publication Date: Nov, 1976. 
AB  - Reviews the book, Behavioral Methods for Chronic Pain and Illness by Wilbert E. Fordyce (1976). The book provides the first comprehensive, clinically based system for managing and evaluating chronic pain and illness. The book tends to prescribe treatment techniques rather than a problem resolution process in the management of chronic pain and illness. Pain is defined, in part, as a social response and maintained by social events available at home, at leisure, or at work. Several excellent case study examples of how to modify and capitalize on these functional relationships are provided in this book. Most important practical and administrative details on program implementation are included in several chapters. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - behavioral methods
KW  - chronic pain and illness
KW  - social events
KW  - scientific methodology
KW  - 1976
KW  - Chronic Illness
KW  - Chronic Pain
KW  - Experimental Methods
KW  - Social Processes
KW  - Pain
KW  - 1976
U2  - Fordyce, Wilbert E. (1976); Behavioral Methods for Chronic Pain and Illness; St. Louis, Mo.: Mosby, 1976. Pp. ix + 236. $9.50
DO  - 10.1037/014744
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06280-049&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-15321-005
AN  - 2005-15321-005
AU  - Gallup, Gordon G. Jr.
AU  - Ledbetter, David H.
AU  - Maser, Jack D.
T1  - Strain Differences Among Chickens in Tonic Immobility: Evidence for an Emotionality Component.
JF  - Journal of Comparative and Physiological Psychology
JO  - Journal of Comparative and Physiological Psychology
JA  - J Comp Physiol Psychol
Y1  - 1976/11//
VL  - 90
IS  - 11
SP  - 1075
EP  - 1081
CY  - US
PB  - American Psychological Association
SN  - 0021-9940
N1  - Accession Number: 2005-15321-005. PMID: 993390 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Gallup, Gordon G. Jr.; State University of New York, Albany, NY, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Emotionality; Animal Strain Differences; Chickens; Tonic Immobility. Minor Descriptor: Animal Breeding; Hybrids (Biology). Classification: Genetics (2510). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Nov, 1976. Copyright Statement: American Psychological Association. 1976. 
AB  - Substantial strain differences in tonic immobility were found between different breeds of chickens. Crossbreeding between strains showing different immobility durations yielded hybrids that exhibited intermediate reactions. For purposes of relating the strain differences in tonic immobility to more conventional measures of emotionality, data were collected on open-field activity, defecation, and adrenal weight. Overall, the results implicated strain-specific differences in emotionality as being the basis for the observed differences in immobility. Latency to defecate in an open field, however, was highly correlated with latency to ambulate. It was argued that defecation, rather than being an absolute measure of fear or emotionality, may in fact be an intermediate response to gradual fear reduction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - emotionality
KW  - tonic immobility
KW  - strain differences
KW  - chickens
KW  - breeds
KW  - hybrids
KW  - 1976
KW  - Animal Emotionality
KW  - Animal Strain Differences
KW  - Chickens
KW  - Tonic Immobility
KW  - Animal Breeding
KW  - Hybrids (Biology)
KW  - 1976
DO  - 10.1037/h0078662
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-15321-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Hamel, Ernest
T1  - Derivatives of Guanosine Triphosphate with Ribose 2'-Hydroxyl Substituents.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1976/11/15/Nov76 Part 2
VL  - 70
IS  - 2
M3  - Article
SP  - 339
EP  - 347
PB  - Wiley-Blackwell
SN  - 00142956
AB  - This report describes the preparation of four methylated and phosphorylated derivatives of GTP, 2′-O-methylguanosine 5′-triphosphate (PPP-Me2′ Guo), guanosine 2′- monophosphate 5′-triphosphate (PPP-Guo-2′P), 3′-O-methylguanosine 5′-triphosphate (PPP-Me3′Guo), and guanosine 3′-monophosphate 5′-triphosphate (PPP-Guo-3′P). These compounds were compared to GTP in their ability to support reactions catalyzed by Escherichia coli initiation factor 2 (IF-2), elongation factor Tu (EF-Tu), and elongation factor G (EF-G). As with previously studied GTP analogues, the nucleotide specificities of IF-2-dependent N-formylmethionylpuromycin formation and EF-Tu-dependent Ac-Phe2-tRNA formation were similar. There was little difference between the reactions supported by GTP, PPP-M2′ Guo, PPP-Me3′ Guo, and PPP-Guo-3′P, but PPP-Guo-2′P was a poor substrate with both enzymes. A spectrum of activity was observed in EF-G-dependent formation of N-acetylphenylalanyl-phenylalanylpuromycin. While PPP-Me2′ Guo was almost as effective as GTP in supporting translocation, PPP-Guo-2′P was a very poor substrate, having even less activity than guanosine 3′-diphosphate 5′-triphosphate. Intermediate activities were observed with PPP-Me3′ Guo and PPP-Guo-3′P, the former nucleotide being more active than the latter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUANOSINE triphosphate
KW  - RIBOSE phosphates
KW  - PHOSPHATES
KW  - HYDROXYL group
KW  - METHYLATION
KW  - NUCLEOTIDES
N1  - Accession Number: 13581318; Hamel, Ernest 1; Affiliation:  1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Nov76 Part 2, Vol. 70 Issue 2, p339; Subject Term: GUANOSINE triphosphate; Subject Term: RIBOSE phosphates; Subject Term: PHOSPHATES; Subject Term: HYDROXYL group; Subject Term: METHYLATION; Subject Term: NUCLEOTIDES; Number of Pages: 9p; Illustrations: 4 Charts, 6 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Huang, Freesia L.
AU  - Glinsmann, Walter H.
T1  - Separation and Characterization of Two Phosphorylase Phosphatase Inhibitors from Rabbit Skeletal Muscle.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1976/11/15/Nov76 Part 2
VL  - 70
IS  - 2
M3  - Article
SP  - 419
EP  - 426
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Two heat-Stable and trypsin-labile inhibitors of phosphorylase phosphatase, designated inhibitor-1 and inhibitor-2, were partially purified from extracts of rabbit skeletal muscle by heating and column chromatography using DEAE-cellulose and Bio-gel P-60. Inhibitor-1 exists in an active phosphorylated form and an inactive dephosphorylated form. The interconversion of phosphorylated inhibitor-1 and dephosphorylated inhibitor-1 is mediated by protein kinase dependent on adenosine 3′:5′-monophosphate (cyclic AMP) and a Mn2+-stimulated phosphoprotein phosphatase. Inhibitory activity of inhibitor-2 is not influenced by treatment with either the kinase or the Mn2+-stimulated phosphatase. The molecular weights of inhibitor-1 and inhibitor-2 estimated by sodium dodecylsulfate-polyacrylamide gel electrophoresis are 26000 and 33000 respectively. Both inhibitor-1 and inhibitor-2 inhibit phosphorylase phosphatase by a mechanism which appears to be non-competitive with respect to the substrate phosphorylase a. Inhibitor fractions at early stages of purification also inhibit cyclic-AMP-dependent histone phosphorylation, but this kinase inhibitory activity resides with a protein moiety which is separable from inhibitor-1 and inhibitor-2. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHATASES
KW  - ENZYME inhibitors
KW  - RABBITS as laboratory animals
KW  - MUSCLES
KW  - PHOSPHORYLATION
KW  - CHROMATOGRAPHIC analysis
KW  - CYCLIC adenylic acid
KW  - CHEMICAL reactions
N1  - Accession Number: 13581342; Huang, Freesia L. 1 Glinsmann, Walter H. 1; Affiliation:  1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: Nov76 Part 2, Vol. 70 Issue 2, p419; Subject Term: PHOSPHATASES; Subject Term: ENZYME inhibitors; Subject Term: RABBITS as laboratory animals; Subject Term: MUSCLES; Subject Term: PHOSPHORYLATION; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CYCLIC adenylic acid; Subject Term: CHEMICAL reactions; Number of Pages: 8p; Illustrations: 1 Chart, 9 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaplan, Allen P.
T1  - ACTIVATION AND CONTROL MECHANISMS OF THE PLASMA KININ-FORMING SYSTEM AND ITS RELATIONSHIP TO COAGULATION AND FIBRINOLYSIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/11/15/
VL  - 67
IS  - 5 Part 2
M3  - Article
SP  - 635
EP  - 637
SN  - 0022202X
AB  - Hageman factor was initially identified as the surface-activated plasma protein which initiates the intrinsic coagulation pathway. This same protein was later shown to be required for the initiation of surface-activated kinin generation and fibrinolysis. When activated Hageman factor was isolated from human serum, a prealbumin fragment derived from Hageman factor was discovered, which was shown to convert prekallikrein to kallikrein, the enzyme that digests kininogen to yield bradykinin. Biologic materials that can activate Hageman factor include endotoxin, uric acid and pyrophosphate crystals.
KW  - KALLIKREIN
KW  - PANCREATIC secretions
KW  - KININS
KW  - BRADYKININ
KW  - PROTEINS
KW  - FIBRINOLYSIS
N1  - Accession Number: 12544434; Kaplan, Allen P. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Bethesda, Maryland, U.S.A.; Source Info: Nov76, Vol. 67 Issue 5 Part 2, p635; Subject Term: KALLIKREIN; Subject Term: PANCREATIC secretions; Subject Term: KININS; Subject Term: BRADYKININ; Subject Term: PROTEINS; Subject Term: FIBRINOLYSIS; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12544434
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fishman, Peter H.
AU  - Brady, Roscoe O.
T1  - Biosynthesis and Function of Gangliosides.
JO  - Science
JF  - Science
Y1  - 1976/11/26/
VL  - 194
IS  - 4268
M3  - Article
SP  - 906
EP  - 915
SN  - 00368075
N1  - Accession Number: 85361169; Fishman, Peter H. 1; Brady, Roscoe O. 2; Affiliations: 1: Research biochemist, Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 2: Chief, Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/26/1976, Vol. 194 Issue 4268, p906; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHO, HAN YONG
AU  - CUTCHINS, ERNEST C.
AU  - RHIM, JOHNG SIK
AU  - HUEBNER, ROBERT J.
T1  - Revertants of Human Cells Transformed by Murine Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1976/11/26/
VL  - 194
IS  - 4268
M3  - Article
SP  - 951
EP  - 953
SN  - 00368075
AB  - Revertants of nonproducer human osteosarcoma (NPIKHOS) cells induced by Kirsten murine sarcoma virus were isolated after incubating at high temperature (40.5°C) overnight and subcloning at 36°C. The morphologic variants, from which murine sarcoma virus could no longer be rescued, had growth properties similar to those of the nontransformed, parent human osteosarcoma cells and did not release RNA-dependent DNA polymerase activity. These revertants were nontumorigenic in nude mice. The revertants supported leukemia virus growth and showed an enhanced sensitivity to murine sarcoma virus superinfection. Thus, the revertants were from human cells transformed by an oncogenic RNA virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361192; CHO, HAN YONG 1,2; CUTCHINS, ERNEST C. 1; RHIM, JOHNG SIK 3; HUEBNER, ROBERT J. 3; Affiliations: 1: Catholic University of America, Washington, D.C. 20064; 2: Microbiological Associates, Inc., Bethesda, Maryland 20014; 3: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 11/26/1976, Vol. 194 Issue 4268, p951; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Martin, W. R.;
T1  - Naloxone
CT  - Naloxone
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1976/12/01/
VL  - 85
IS  - Dec
SP  - 765
EP  - 768
SN  - 00034819
AD  - Div. of Research, Addiction Research Center, National Institute on Drug Abuse, Lexington, Kentucky
N1  - Accession Number: 14-3875; Language: English; Chemical Name: Naloxone--465-65-6; References: 24; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Naloxone is discussed, according to its' pharmacology, mechanism of action, and clinical uses.
KW  - Naloxone--narcotic antagonists-;
KW  - Narcotic antagonists--naloxone--effects, pharmacology, and mechanism of action, discussion;
KW  - Mechanism of action--naloxone--effects, and pharmacology, discussion;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MacIntyre, Ross J.
AU  - O'Brien, Stephen J.
T1  - INTERACTING GENE-ENZYME SYSTEMS IN DROSOPHILA.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1976/12//
VL  - 10
M3  - Article
SP  - 281
EP  - 318
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Focuses on the research about the genetics of Drosophila melanogaster.  Details on the phenotypes of the morphological mutants; Effects of pyrimidine analogues on wing development; Characterization of the enzyme loci.
KW  - RESEARCH
KW  - GENETICS
KW  - DROSOPHILA melanogaster
KW  - PHENOTYPE
KW  - PYRIMIDINES
KW  - ENZYMES
N1  - Accession Number: 12409090; MacIntyre, Ross J. 1 O'Brien, Stephen J. 2; Affiliation:  1: Section of Genetics, Development, and Physiology, Cornell University, Ithaca, New York  2: Cell Biology Section, Viral Biology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland; Source Info: 1976, Vol. 10, p281; Subject Term: RESEARCH; Subject Term: GENETICS; Subject Term: DROSOPHILA melanogaster; Subject Term: PHENOTYPE; Subject Term: PYRIMIDINES; Subject Term: ENZYMES; Number of Pages: 38p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Klein, Robert P.
AU  - Durfee, Joan T.
T1  - Infants' Reactions to Unfamiliar Adults versus Mothers.
JO  - Child Development
JF  - Child Development
Y1  - 1976/12//
VL  - 47
IS  - 4
M3  - Article
SP  - 1194
EP  - 1196
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12191202; Klein, Robert P. 1 Durfee, Joan T. 1; Affiliation:  1: Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development.; Source Info: Dec1976, Vol. 47 Issue 4, p1194; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1467-8624.ep12191202
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Makinodan, T.
AU  - Albright, Julia W.
AU  - Good, P.I.
AU  - Peter, C.P.
AU  - Heidrick, Margaret L.
T1  - Reduced humoral immune activity in long-lived old mice: An approach to elucidating its mechanisms.
JO  - Immunology
JF  - Immunology
Y1  - 1976/12//
VL  - 31
IS  - 6
M3  - Article
SP  - 903
EP  - 911
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Spleen cells from young (3-5 months) and old (22-27 months) mice were assessed in cultures, both in vivo and in vitro, for their antisheep RBC response separately and in mixtures. Pooled young spleens, pooled old spleens, and individual old spleens were analysed. The response of pure young spleen cells was always higher than that of pure old spleen cells (∼30 times). The responses of mixtures were either less than (i.e. reduced; frequency ∼65 per cent), comparable to (i.e. additive; frequency ∼10 per cent), or greater than (i.e. elevated; frequency ∼30 per cent) the sum of the responses given by equivalent numbers of pure young and pure old spleen cells. The reduced response was observed in mixtures containing cells from histologically normal old spleens, old spleens with tumours and old spleens with atrophic follicles. Additive and elevated responses were observed only in mixtures containing cells from histologically normal old spleens. The reduced response is explicable in terms of excessive numbers of suppressor cells in old spleens that can prevent young immunocompetent cells from responding maximally to the test antigen. The additive response can be accounted for by a reduction in number of immunocompetent cells in old spleens and/or a decrease in their functional efficiency. The elevated response can be explained by a reduction in number of at least one type of immunocompetent cell in old spleens that exists in excess in young spleens. These results indicate that there are several types of cellular changes responsible for the decrease in humoral immune activity in old mice. Pooling of old spleens, as was commonly done in the past, should therefore be discouraged. Not only might it selectively favour the expression of old spleens with an excess of supressor cells but it conceivably could result in an elevated response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE system
KW  - SPLEEN
KW  - HEMATOPOIETIC system
KW  - LYMPHOID tissue
KW  - IMMUNOLOGY
KW  - MICE
N1  - Accession Number: 13373699; Makinodan, T. 1,2 Albright, Julia W. 1 Good, P.I. 3 Peter, C.P. 2,4 Heidrick, Margaret L. 1,2,5; Affiliation:  1: Laboratory of Cellular and Comparative Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, PHS, U.S. Department of health, Education and Welfare, Bethesda and Baltimore City Hospitals, Baltimore, Maryland  2: Oak Ridge National Laboratory, Oak Ridge, Tennessee  3: The Upjohn Company, Kalamazoo, Michigan  4: Merck, Sharp and Dohme, West Point, Pennsylvania  5: Department of Biochemistry, University of Nebraska, Omaha, Nebraska U.S.A.; Source Info: Dec76, Vol. 31 Issue 6, p903; Subject Term: IMMUNE system; Subject Term: SPLEEN; Subject Term: HEMATOPOIETIC system; Subject Term: LYMPHOID tissue; Subject Term: IMMUNOLOGY; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - RPRT
AU  - Hertz, Kenneth C.
AU  - Gazze, Laura A.
AU  - Katz, Stephen I.
T1  - IMMUNOFLUORESCENT LOCALIZATION OF BASEMENT MEMBRANE IN LESIONS OF DERMATITIS HERPETIFORMIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/12//
VL  - 67
IS  - 6
M3  - Report
SP  - 683
EP  - 687
SN  - 0022202X
AB  - Dermatitis herpetiformis (DH) is a blistering disease with a characteristic histology that includes papillary edema, neutrophilic papillary microabscesses, and development of subepidermal blisters. In spite of this pathologic sequence occurring entirely beneath the basement membrane zone, prior studies have indicated that the basement membrane, as defined by periodic acid-Schiff (PAS) or silver stains, lies at the floor of fully formed blisters or is destroyed by the disease process. To more accurately assess its location in primary lesions of DH, the basement membrane was stained using immunofluorescent techniques. Lesional skin from 5 patients with DH was used as substrate for indirect immunofluorescence with sera from patients with bullous pemphigoid (BP) and fluoresceinated antihuman IgG. The BP-stained basement membrane was attached to the roofs of early blisters, where it would be expected from the pathologic sequence of blister formation. PAS stains of the same or serial sections show the basement membrane to be in the roof or at the floor of the blisters. PAS stains of sections from formalin-fixed lesional skin, on the other hand, show the basement membrane to routinely lie at the blister floor, when not destroyed. The BP-stained epidermal basement membrane has greater anatomic and functional significance than either the PAS- or silver-stained basement membrane for two reasons: (1) it corresponds to a specific morphologic structure, the lamina lucida, a part of the epidermis, and remains attached to the rest of the epidermis unless destroyed; and (2) it is antigenic, capable of binding with BP antibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOFLUORESCENCE
KW  - BASAL lamina
KW  - DERMATITIS herpetiformis
KW  - SKIN diseases
KW  - EPITHELIUM
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 12598497; Hertz, Kenneth C. 1 Gazze, Laura A. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec76, Vol. 67 Issue 6, p683; Subject Term: IMMUNOFLUORESCENCE; Subject Term: BASAL lamina; Subject Term: DERMATITIS herpetiformis; Subject Term: SKIN diseases; Subject Term: EPITHELIUM; Subject Term: IMMUNOGLOBULINS; Number of Pages: 5p; Document Type: Report
L3  - 10.1111/1523-1747.ep12598497
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Katz, Stephen I.
AU  - Hertz, Kennerth C.
AU  - Crawford, Peggy S.
AU  - Gazze, Laura A.
AU  - Frank, Michael M.
AU  - Lawley, Thomas J.
T1  - EFFECT OF SULFONES ON COMPLEMENT DEPOSITION IN DERMATITIS HERPETIFORMIS AND ON COMPLEMENT-MEDIATED GUINEA-PIG REACTIONS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/12//
VL  - 67
IS  - 6
M3  - Article
SP  - 688
EP  - 690
SN  - 0022202X
AB  - The role of complement and the mechanism of sulfone action in dermatitis herpetiformis (DH) have not yet been established; prior studies have presented conflicting data regarding the effect of sulfones on complement activation and deposition. Thirty-eight DH patients were studied. Twenty-four of 25 perilesional skin biopsies and 50 of 67 normal-appearing skin biopsies showed the third component of complement (C3) deposited in areas corresponding to those of IgA deposition. Nine of 10 patients with bound C3 in normal-appearing and perilesional skin during periods of active disease continued to have C3 in normal-appearing skin when treatment with sulfones kept them completely free of lesions for 2 to 8 weeks. When either Hartley-strain or C4-deficient guinea pigs were given up to 150 mg/kg sulfoxone (a water-soluble sulfone) intraperitoneally for 8 days before elicitation of active Arthus, reverse passive Arthus reactions, or Forssman shock, there was no difference in time course, character, or intensity of reactions when compared to saline-treated control animals. We were therefore unable to demonstrate any effect of sulfones on complement deposition in DH skin or on complement activation in classical or alternate complement pathway-mediated guinea-pig reactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SULFONES
KW  - DERMATITIS herpetiformis
KW  - SKIN diseases
KW  - IMMUNOGLOBULINS
KW  - GUINEA pigs as laboratory animals
KW  - SKIN -- Biopsy
N1  - Accession Number: 12598565; Katz, Stephen I. 1 Hertz, Kennerth C. 1 Crawford, Peggy S. 1 Gazze, Laura A. 1 Frank, Michael M. 1 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch and Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Dec76, Vol. 67 Issue 6, p688; Subject Term: SULFONES; Subject Term: DERMATITIS herpetiformis; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: GUINEA pigs as laboratory animals; Subject Term: SKIN -- Biopsy; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12598565
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yaoita, Hideo
AU  - Hertz, Kenneth C.
AU  - Katz, Stephen I.
T1  - DERMATITIS HERPETIFORMIS: IMMUNOELECTRONMICROSCOPIC AND ULTRASTRUCTURAL STUDIES OF A PATIENT WITH LINEAR DEPOSITION OF IgA.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1976/12//
VL  - 67
IS  - 6
M3  - Article
SP  - 691
EP  - 695
SN  - 0022202X
AB  - Using immunoelectronmicroscopic techniques, we have demonstrated three distinct patterns of IgA deposition in the skin of patients with dermatitis herpetiformis. The least common of these patterns is the localization of reaction products to the lamina lucida. As this is the location of the immunoreactants in bullous pemphigoid and herpes gestationis and because the ultrastructural findings in our patient's early lesional skin differ from those usually seen in patients with dermatitis herpetiformis, we herein detail this patient's clinical, histologic, immunologic, and ultrastructural findings. The most prominent findings are (1) IgA deposition in the lamina lucida, (2) vesicle formation between basal lamina and the basal cells, and (3) fibrin-like material in the epidermis with showering into the dermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DERMATITIS herpetiformis
KW  - SKIN diseases
KW  - IMMUNOGLOBULINS
KW  - ELECTRON microscopic diagnosis
KW  - BASAL lamina
KW  - EPIDERMIS
N1  - Accession Number: 12598569; Yaoita, Hideo 1 Hertz, Kenneth C. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Dec76, Vol. 67 Issue 6, p691; Subject Term: DERMATITIS herpetiformis; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: ELECTRON microscopic diagnosis; Subject Term: BASAL lamina; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12598569
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chapman, Judith-Anne W.
T1  - A Comparison of the X[sup2], -2 Log R, and Multinomial Probability Criteria for Significance Tests When Expected Frequencies Are Small.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1976/12//
VL  - 71
IS  - 356
M3  - Article
SP  - 854
SN  - 01621459
AB  - The exact multinomial, and exact and Chi[sup 2] probabilities for X[sup 2] and -2 log R have been compared. The -2 log R Chi[sup 2] probabilities are on average closer to the multinomial than are the corresponding X[sup 2] probabilities. The differences between the exact and Chi[sup 2] probabilities are usually smaller for X[sup 2] than for -2 log R. A pattern was observed among the five types of significance levels, and an explanation was proposed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROBABILITY theory
KW  - CORRELATION (Statistics)
KW  - MATHEMATICAL statistics
KW  - REGRESSION analysis
KW  - COMBINATIONS (Mathematics)
KW  - PROBABILITY measures
KW  - LEAST squares
N1  - Accession Number: 4608254; Chapman, Judith-Anne W. 1; Affiliations: 1: Research Fellow of the National Cancer Institute of Canada.; Issue Info: Dec76, Vol. 71 Issue 356, p854; Thesaurus Term: PROBABILITY theory; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: REGRESSION analysis; Subject Term: COMBINATIONS (Mathematics); Subject Term: PROBABILITY measures; Subject Term: LEAST squares; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - HARRIS, CURTIS C.
AU  - AUTRUP, HERMAN
AU  - CONNOR, ROBERT
AU  - BARRETT, LUCY A.
AU  - MCDOWELL, ELIZABETH M.
AU  - TRUMP, BENJAMIN F.
T1  - Interindividual Variation in Binding of Benzo[a]pyrene to DNA in Cultured Human Bronchi.
JO  - Science
JF  - Science
Y1  - 1976/12/03/
VL  - 194
IS  - 4269
M3  - Article
SP  - 1067
EP  - 1069
SN  - 00368075
AB  - The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean ± standard error of 34.2 ± 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361234; HARRIS, CURTIS C. 1; AUTRUP, HERMAN 1; CONNOR, ROBERT 2; BARRETT, LUCY A. 3; MCDOWELL, ELIZABETH M. 3; TRUMP, BENJAMIN F. 3; Affiliations: 1: Human Tissue Studies Section, National Cancer Institute, Bethesda, Maryland 20014; 2: Field Studies and Statistics, National Cancer Institute; 3: Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201; Issue Info: 12/ 3/1976, Vol. 194 Issue 4269, p1067; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WAXMAN, SAMUEL
AU  - BRUCKNER, HOWARD
AU  - BERTINO, J. R.
AU  - GOLDIN, ABRAHAM
T1  - Antitumor Drug Interactions: Additional Data.
JO  - Science
JF  - Science
Y1  - 1976/12/10/
VL  - 194
IS  - 4270
M3  - Article
SP  - 1112
EP  - 1116
SN  - 00368075
N1  - Accession Number: 85361242; WAXMAN, SAMUEL 1; BRUCKNER, HOWARD 1; BERTINO, J. R. 2; GOLDIN, ABRAHAM 2,3; Affiliations: 1: Cancer Chemotherapy Foundation Laboratory, Division of Medical Oncology, Mount Sinai School of Medicine, City University of New York, New York 10029; 2: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510; 3: Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/10/1976, Vol. 194 Issue 4270, p1112; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gold, P. W.;
AU  - Goodwin, F. K.;
AU  - Wehr, T.;
AU  - Rebar, R.;
AU  - Sack, R.;
T1  - Growth hormone and prolactin response to levodopa in affective illness
CT  - Growth hormone and prolactin response to levodopa in affective illness
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1976/12/11/
VL  - 2
IS  - Dec 11
SP  - 1308
EP  - 1309
SN  - 00237507
AD  - Section on Psychiatry, Lab. of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 14-2335; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents levodopa; References: 11; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - Growth hormone and prolactin response to levodopa was assessed in 20 patients with a primary affective disorder and in 10 healthy volunteers. After an overnight fast, all subjects received 500 mg of oral levodopa, and plasma was drawn sequentially over a 3 hr period and analyzed for growth hormone and prolactin. No relationship was found between neuroendocrine responses to levodopa and age. There was no significant difference in growth hormone or prolactin response to levodopa between the whole group of depressed patients and controls. However, the bipolar group had a significantly larger peak growth hormone increment than did unipolar patients (P \LT/ 0.01) or controls (P \LT/ 0.01).
KW  - Levodopa--effects-;
KW  - Psychotherapeutic agents--levodopa--effects, on growth hormone and prolactin response, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - BERGMANN, FRED H.
T1  - A Bank of Mammalian DNA Fragments.
JO  - Science
JF  - Science
Y1  - 1976/12/17/
VL  - 194
IS  - 4271
M3  - Article
SP  - 1226
EP  - 1226
SN  - 00368075
N1  - Accession Number: 85361280; BERGMANN, FRED H. 1; Affiliations: 1: Genetics Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 12/17/1976, Vol. 194 Issue 4271, p1226; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DEVARE, SUSHILKUMAR G.
AU  - STEPHENSON, JOHN R.
AU  - SARMA, PADMAN S.
AU  - AARONSON, STUART A.
AU  - CHANDER, SATISH
T1  - Bovine Lymphosarcoma: Development of a Radioimmunologic Technique for Detection of the Etiologic Agent.
JO  - Science
JF  - Science
Y1  - 1976/12/24/
VL  - 194
IS  - 4272
M3  - Article
SP  - 1428
EP  - 1430
SN  - 00368075
AB  - A highly sensitive and specific radioimmunoassay has been developed for the major structural protein of an oncornavirus etiologically associated with bovine lymphosarcoma. This test can be used to identify cattle which have been exposed to the bovine leukemia virus and may thus develop or transmit the disease. Analysis of randomly obtained serums indicates that infection with this virus is widespread among cattle. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361351; DEVARE, SUSHILKUMAR G. 1; STEPHENSON, JOHN R. 1; SARMA, PADMAN S. 1; AARONSON, STUART A. 1; CHANDER, SATISH 2; Affiliations: 1: Laboratory of RNA Tumor Viruses, National Cancer Institute, Bethesda, Maryland 20014; 2: Animal Disease Research Institute, Ottawa, Ontario, Canada K2H 8P9; Issue Info: 12/24/1976, Vol. 194 Issue 4272, p1428; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-18626-000
AN  - 9999-18626-000
AU  - Martin, William R.
AU  - Hewett, Barbara B.
AU  - Baker, Alice J.
AU  - Haertzen, Charles A.
T1  - Maturation Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1977///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-18626-000. Partial author list: First Author & Affiliation: Martin, William R.; National Institute on Drug Abuse, Addiction Research Center, Division of Research, Lexington, Kentucky, United States. Release Date: 20130408. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: The measure uses a True or False response format.. Language: English. Constructs: Maturity; Personality Traits; Classification: Personality (7200). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). 
AB  - Purpose: The Maturation Scale was designed to measure feeling states and attitudes assumed to be related to antisocial personality: impulsivity, egocentricity, hypophoria, sociopathic feelings and increased needs in drug addiction and alcoholism.
AB  - Description: The Maturation Scale (Martin et al., 1977) measures immaturity and current existing feeling states and attitudes that are presumed to be related to antisocial personality. This questionnaire is adapted from a list of 347 items related to impulsivity, egocentricity, hypophoria, sociopathic feelings, and increased needs accumulated from the Addiction Research Center Inventory (ARCI), the Minnesota Multiphasic Personality Inventory (MMPI) and the California Psychological Inventory (CPI), which were related to psychopathy, mania, irresponsibility, popularity, social withdrawal and antisocial feelings. Hypochondriacal, Depression and Opiate Withdrawal Scale items which could be conceived as related to hypophoria were not selected. The resulting questionnaire consists of 67 items classified into five categories: impulsivity, egocentricity, needs-basic needs, hypophoria-depression and sociopathy. The Egocentricity subscale (7 items) contains items related to selfishness, inability to love, and callousness. The Impulsivity subscale (6 items) measures thoughtlessness and uninhibited behavior. The Need subscale (11 items) assess sexual desire, hunger, body health, pain, and general wanting. The Hypophoria subscale (27 items) measures a general negative perception of life, poor self-image, feelings of being disrespected, disapproved of and unappreciated, and feelings of inefficiency or ineptness, withdrawal from competition, worry, and anger. The Sociopathy subscale (16 items) assess antisocial feelings, feelings of noncomformity, poor judgment, and lack of social concern. Respondents are asked their level of agreement 'according to the way you feel today.' Using male prisoners, alcoholics, faculty and students of a college and theologic seminary in the sample, the data suggests the validity of the Maturation Scale has been only partially validated. Egocentricity, Need, Hypophoria and Sociopathy subscale scores are correlated with Maturation Scale scores for all groups of subjects. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Egocentricity Subscale
KW  - Hypophoria Subscale
KW  - Impulsivity Subscale
KW  - Maturation Scale
KW  - Need Subscale
KW  - Sociopathy Subscale
KW  - Test Development
KW  - Validity
U5  - Maturation Scale [Test Development]Aspects of the psychopathology and pathophysiology of addiction. (AN: 1978-10093-001 from PsycINFO) Martin, William R.; Hewett, Barbara B.; Baker, Alice J.; Haertzen, Charles A.; May, 1977. Source: Drug and Alcohol Dependence. 2(3), Elsevier Science, Netherlands; May, 1977; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Location: United States; Sample: Prisoners (Ages 27-50); Alcoholics (Ages 22-54); College Faculty/Students (Ages 22-55) Keywords: Egocentricity Subscale; Hypophoria Subscale; Impulsivity Subscale; Maturation Scale; Need Subscale; Sociopathy Subscale; Test Development; Validity; Subjects: Antisocial Behavior; Egocentrism; Emotional Maturity; Human Development; Impulsiveness; Needs; Rating Scales; Test Construction; Test Validity;
DO  - 10.1037/t18626-000
L3  - Full; Full text; 999918626_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Anders, E. Margot
AU  - McAdam, K. P. W. J.
AU  - Anders, R. F.
T1  - Cell-mediated immunity in amyloidosis secondary to lepromatous leprosy.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1977/01//
VL  - 27
IS  - 1
M3  - Article
SP  - 111
EP  - 117
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Cell-mediated immunity in lepromatous leprosy patients with and without amyloidosis has been studied. Amyloidosis occurred mostly in patients with a history of recurrent erythema nodosum leprosum (ENL) reactions. For this reason, two control groups of leprosy patients were included, one having a history of recurrent ENL and the other little or no ENL. The lack of responsiveness to lepromin in vivo and in vitro, characteristic of lepromatous leprosy, was not altered by the presence of amyloidosis or a history of ENL. No significant difference between the patient groups was observed in the response to PPD in vitro, but skin reactivity to PPD was significantly lower in the patients with amyloidosis than in those without amyloidosis. In contrast, the PHA responses of patients with amyloidosis were significantly higher than those of control patients without a history of ENL, but not significantly different from those of control patients with a history of recurrent ENL. Lepromatous leprosy patients who develop amyloidosis thus appear to belong to a group, susceptible to repeated attacks of ENL, whose PHA responses are higher than those of other lepromatous leprosy patients. The lower skin reactivity to PPD observed in the amyloid group may reflect a general impairment in delayed cutaneous hypersensitivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNITY
KW  - LEPROSY
KW  - AMYLOIDOSIS
KW  - ERYTHEMA
KW  - GLYCOPROTEINS
KW  - LYMPHOPROLIFERATIVE disorders
N1  - Accession Number: 16029297; Anders, E. Margot 1,2 McAdam, K. P. W. J. 1,3 Anders, R. F. 1,4; Affiliation:  1: Faculty of Medicine, University of Papua New Guinea, Port Moresby and Institute of Medical Research, Goroka, Papua New Guinea  2: Department of Microbiology, University of Melbourne, Parkville, Victoria 3052, Australia.  3: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014, U.S.A.  4: Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.; Source Info: Jan1977, Vol. 27 Issue 1, p111; Subject Term: IMMUNITY; Subject Term: LEPROSY; Subject Term: AMYLOIDOSIS; Subject Term: ERYTHEMA; Subject Term: GLYCOPROTEINS; Subject Term: LYMPHOPROLIFERATIVE disorders; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bachur, N. R.;
AU  - Riggs, C. E.;
AU  - Green, M. R.;
AU  - Langone, J. J.;
AU  - Van Vunakis, H.;
AU  - \ET/;
T1  - Plasma adriamycin and daunorubicin levels by fluorescence and radioimmunoassay
CT  - Plasma adriamycin and daunorubicin levels by fluorescence and radioimmunoassay
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1977/01/01/
VL  - 21
IS  - Jan
SP  - 70
EP  - 77
SN  - 00099236
AD  - Reprints: Lab. of Clinical Biochemistry, Baltimore Cancer Research Center, NCI, 3100 Wyman Park Dr., Baltimore, Maryland 21221
AD  - Lab. of Clinical Biochemistry, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, and; Graduate Dept. of Biochemistry, Brandeis Univ., Waltham, Massachusetts
N1  - Accession Number: 14-5987; Language: English; Trade Name: Daunomycin--Adriamycin; Generic Name: Daunorubicin; Doxorubicin; Chemical Name: Daunorubicin--20830-81-3 Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 13; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2  - The pharmacokinetics of daunomycin (daunorubicin; I) and adriamycin (doxorubicin; II) were followed by fluorescence and radioimmunoassay in 25 and 4 patients, respectively. Patients received between 25-100 micromole/sq m of II or 171-308 micromole/sq m of I. The drugs were administered IV and blood samples were assayed immediately before and at appropriate times after drug injection. The plasma drug decay followed first order kinetics in a triphasic pattern. Both assays showed similar decay up to 4 hr but diverged at that point with the fluorescence assay yielding higher values. Pharmacokinetic differences were amplified in patients with liver dysfunction. The radioimmunoassay offered the capability to measure II and I in clinical settings in which fluorescence assay was not available.
KW  - Daunorubicin--pharmacokinetics-;
KW  - Doxorubicin--pharmacokinetics-;
KW  - Pharmacokinetics--daunorubicin--blood levels, first order kinetics, fluorescence, radioimmunoassay, patients;
KW  - Pharmacokinetics--doxorubicin--blood levels, first order kinetics, fluorescence, radioimmunoassay, patients;
KW  - Blood levels--daunorubicin--pharmacokinetics, fluorescence, radioimmunoassay, patients;
KW  - Blood levels--doxorubicin--pharmacokinetics, fluorescence, radioimmunoassay, patients;
KW  - Fluorometry--daunorubicin--comparison, radioimmunoassay, blood levels, patients;
KW  - Fluorometry--doxorubicin--comparison, radioimmunoassay, blood levels, patients;
KW  - Radioimmunoassay--daunorubicin--comparison, fluorometry, blood levels, patients;
KW  - Radioimmunoassay--doxorubicin--comparison, fluorometry, blood levels, patients;
KW  - Antineoplastic agents--daunorubicin--pharmacokinetics, patients;
KW  - Antineoplastic agents--doxorubicin--pharmacokinetics, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - Design, implementation, and management of a comprehensive system of information services for cancer researchers
JO  - In Fry, Bernard M., Comp.; Shepherd, Clayton A., Comp. Information Management In The 1980's. Proceedings Of The Asis 40th Annual Meeting. Chicago, September 26 To October 1, 1977. Volume 14. Part I. Abstracts Of Papers. Part Ii. Full Papers. 1977. Knowled
JF  - In Fry, Bernard M., Comp.; Shepherd, Clayton A., Comp. Information Management In The 1980's. Proceedings Of The Asis 40th Annual Meeting. Chicago, September 26 To October 1, 1977. Volume 14. Part I. Abstracts Of Papers. Part Ii. Full Papers. 1977. Knowled
Y1  - 1977///
M3  - Book
AB  - Steps leadings to the establishment of the international cancer research data bank (icrdb) program and its production of a wide variety of useful information services and products for cancer researchers are described. The following major icrdb program activities are outlined: 1) establishment of rapidly growing on-line information services, collectively referred to as cancerline. Four data bases (cancerlit, cancerproj, clinprot, and cancercite) which make up the cancerline system are discussed; 2) production and distribution of publications for cancer researchers. A growing series of current awareness publications called cancergrams and series of 'special listings' containing descriptions of current cancer research projects are described; 3) a number of other information services, products, and related activities are also mentioned.
N1  - Accession Number: ISTA1301162; Schneider, John H 1; Affiliations: 1 : International Cancer Research Data Bank Program, Office Of International Affairs, National Cancer Institute, Bethesda, Maryland.;  Source Info: 1977; Note: Update Code: 1300; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cherry, J. D.;
AU  - McIntosh, K.;
AU  - Connor, J. D.;
AU  - Benenson, A. S.;
AU  - Alling, D. W.;
AU  - \ET/;
T1  - Primary percutaneous vaccination
CT  - Primary percutaneous vaccination
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1977/01/01/
VL  - 135
IS  - Jan
SP  - 145
EP  - 154
SN  - 00221899
AD  - Infect. Dis. Branch, National Institute of Allergy and Infectious Diseases, Bldg. 31, Room 7A-10, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-3165; Language: English; References: 22; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - In an investigation of the antigenicity and reactogenicity of 4 smallpox vaccines, 786 children received primary percutaneous vaccination with vaccine in one of 3 concentrations, 10\SU/6\BS/,10\SU/7\BS/,10\SU/8\BS/ pock forming units/ml. Dose response curves indicated that the 3 licensed vaccines (New York City Board of Health strains grown in calf lymph or chorioallantoic membrane, and the Lister vaccine) had similar potencies, but the CV-1 strain was about 10-fold less infections. CV-1 also produced smaller skin lesions than the other 3 vaccines, and the incidence of fever in CV-1 vaccines who developed either major reactions or serum antibody was not significantly different from that in children in all vaccine groups with no evidence of take. Hemagglutination-inhibiting antibody was consistently seen in individuals who received potent New York City and Lister vaccines, and neutralizing antibody was induced in 82-85% of children in this group who had some evidence of take (production of hemagglutination-inhibiting antibody or major reaction). Only 30% of CV-1 vaccines with takes produced neutralizing antibody. Minor complications occurred in all groups, but most often in children who received the New York City strains.
KW  - Smallpox vaccines--immunization--primary, percutaneous, 3 strains compared, children;
KW  - Immunization--smallpox--vaccines, primary, percutaneous, 3 strains compared, children;
KW  - Toxicity--smallpox vaccines--side effects, percutaneous, 3 strains compared, children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - McIntosh, K.;
AU  - Cherry, J. D.;
AU  - Benenson, A. S.;
AU  - Connor, J. D.;
AU  - Alling, D. W.;
AU  - \ET/;
T1  - Standard percutaneous vaccination of children who received primary percutaneous vaccination
CT  - Standard percutaneous vaccination of children who received primary percutaneous vaccination
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1977/01/01/
VL  - 135
IS  - Jan
SP  - 155
EP  - 166
SN  - 00221899
AD  - Infectious Diseases Branch, National Institute of Allergy and Infectious Diseases, Bldg. 31, Room 7A-10, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-3169; Language: English; References: 16; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2  - A standard challenge with percutaneous smallpox vaccine was administered to 629 children 6 to 12 months after percutaneous primary inoculation with one of 4 vaccines. Of those who had had major reactions on primary vaccination, 8-21% responded to revaccination with a typical primary type skin response. In contrast, such a primary type response occurred in 50% of those who on primary vaccination had developed serum antibody in the absence of major reactions and in 83% of those who had had no serologic or clinical evidence of primary take. Skin lesions on revaccination tended to be largest in those whose primary vaccination was with CV-1, although fever and minor complication were not more frequent. Moreover, even in children who had received CV-1 vaccine, skin responses to challenge vaccine were clearly attenuated when compared with responses of children who had not had takes on primary vaccination. Sizes of lesions and acceleration of skin erythema after challenge were related in most children to titers of both hemagglutination-inhibiting and neutralizing antibody at the time of revaccination.
KW  - Smallpox vaccines--immunization--reactions, children;
KW  - Immunization--smallpox--vaccines, challenge, reactions, children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Cherry, J. D.;
AU  - Connor, J. D.;
AU  - McIntosh, K.;
AU  - Benenson, A. S.;
AU  - Alling, D. W.;
AU  - \ET/;
T1  - Standard percutaneous revaccination of children who received primary subcutaneous vaccination
CT  - Standard percutaneous revaccination of children who received primary subcutaneous vaccination
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1977/01/01/
VL  - 135
IS  - Jan
SP  - 176
EP  - 182
SN  - 00221899
AD  - Infectious Diseases Branch, National Institute of Allergy and Infectious Diseases, Bldg. 31 Room 7A-10, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-3168; Language: English; References: 17; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Six months after SC vaccination with one of 4 smallpox vaccines, 665 children were challenged with a standard percutaneous smallpox vaccine. Response to reimmunization was characterized by a significant acceleration and diminution of skin response, but not to the degree seen in an equivalent group who had received their primary immunization percutaneously. Fever after revaccination was absent if there had been a take with primary SC vaccination. The overall incidence of minor vaccine related complications with revaccination was 2.5%. The neutralizing antibody response to revaccination was markedly reduced, as compared to that of children who received either one or 2 successful percutaneous vaccinations. SC vaccination followed by percutaneous vaccination is not recommended as a schedule for smallpox immunization, because complications are not avoided, and the incidence and mean titer of resultant neutralizing antibody are low.
KW  - Smallpox vaccines--percutaneous--following SC vaccination, evaluations, children;
KW  - Immunization--smallpox--vaccines, percutaneous, following SC vaccination, evaluations, children;
KW  - Drug administration--routes--smallpox vaccines, percutaneous, following SC, evaluations, children;
KW  - Rational therapy--smallpox vaccines--percutaneous, following SC, evaluations, children;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Feldmann, R J
AU  - Heller, S.r.
T1  - A computer-based chemical information system
JO  - Science 195(4275), 253-259 (1977 January 21). 27 Ref
JF  - Science 195(4275), 253-259 (1977 January 21). 27 Ref
Y1  - 1977///
M3  - Book Chapter
AB  - A description is presented of the real-time on-line internationally accessible chemical information system (cis) under development by cooperation between nih and epa. (not to be confused with the identical acronym referring to congressional information service). Numerical and bibliographic data included so far in the nih-epa system, based on the use of a pdp-10 resident computer plus several software packages, are mass spectra, carbon-13 nuclear magnetic resonance (nmr) spectra, and x-ray diffraction (crystallographic) spectra. In addition, interactive program packages are available for performing various mathematical operations on user-supplied data; for determining isotopic label incorporation (labdet); for conformational analysis of molecules in solution (camseq); for performing substructure searches (sss); and so forth. Reasonable search costs are claimed as one major advantage of the developing system.
N1  - Accession Number: ISTA1202432; Feldmann, R J 1; Heller, S.r. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland;  Source Info: 1977; Note: Update Code: 1200; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Isaacs, Leslie Dashew
T1  - Art-Therapy Group for Latency Age Children.
JO  - Social Work
JF  - Social Work
Y1  - 1977/01//
VL  - 22
IS  - 1
M3  - Article
SP  - 57
PB  - Oxford University Press / USA
SN  - 00378046
AB  - The article focuses on the usefulness of art therapy in treating latency age children who had problems with peer relationships. It presents a review of the literature pertaining to art therapy and child group therapy, which shows no precedent for group art therapy with children. It depicts the goals of art-therapy group, which were both diagnostic and therapeutic. It was anticipated that the sharing of art materials, the process of producing artwork, and the discussion of the production would facilitate the group process. The group was composed of four girls between the ages of nine and eleven. Two girls dropped out after the first six weeks and two other girls later joined. From its first session the group demonstrated its value in attaining both the diagnostic and treatment goals. The article states that as the group progressed the artwork became less important. The girls found other means of interacting, as they become more comfortable sharing feelings, thoughts, and experiences verbally. Thus, the art-therapy group for latency age girls was found to be an excellent diagnostic tool in demonstrating the particular behavior that led to each child's peer-related problems.
KW  - ART therapy
KW  - GROUP psychotherapy
KW  - PEERS
KW  - INTERPERSONAL relations
KW  - CHILDREN
KW  - PSYCHOTHERAPY
N1  - Accession Number: 5268951; Isaacs, Leslie Dashew 1; Affiliation:  1: Assistant to Coordinator, Primary Prevention Programs, National Institute of Mental Health, Rockville, Md.; Source Info: Jan77, Vol. 22 Issue 1, p57; Subject Term: ART therapy; Subject Term: GROUP psychotherapy; Subject Term: PEERS; Subject Term: INTERPERSONAL relations; Subject Term: CHILDREN; Subject Term: PSYCHOTHERAPY; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2009-05428-001
AN  - 2009-05428-001
AU  - Torrey, E. Fuller
T1  - On the sociology of lost ideas in schizophrenia research and the watering of gardens.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1977///
VL  - 3
IS  - 2
SP  - 176
EP  - 178
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-05428-001. PMID: 887900 Partial author list: First Author & Affiliation: Torrey, E. Fuller; Center for Studies of Schizophrenia, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Schizophrenia; Trends. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1977. 
AB  - Just as there are fashions in etiquette, sexual mores, and dress styles in our culture, so there are also fashions in schizophrenia research. Some research ideas are in fashion, while others are considered unfashionable or old fashioned. One consequence of these fashions is that potentially valuable research ideas get discarded for years at a time. There is a sociology of lost ideas in our research field, and probably in all research fields. There are certain ideas which are socially acceptable within the research community and others which are not acceptable. Acceptability is only partly determined by objective evidence or evaluation of the idea. Several suggestions are made for addressing this situation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia research
KW  - ideas
KW  - trends
KW  - 1977
KW  - Experimentation
KW  - Schizophrenia
KW  - Trends
KW  - 1977
DO  - 10.1093/schbul/3.2.176
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09713-003
AN  - 2005-09713-003
AU  - Durell, Jack
AU  - Katz, Martin M.
T1  - Introduction to the Issue: The Changing Clinical Picture of Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1977///
VL  - 3
IS  - 4
SP  - 528
EP  - 530
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2005-09713-003. PMID: 594682 Partial author list: First Author & Affiliation: Durell, Jack; Psychiatric Institute, Washington, DC, US. Other Publishers: Oxford University Press. Release Date: 20060306. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Schizophrenia. Minor Descriptor: Deinstitutionalization; Drug Therapy. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 3. Issue Publication Date: 1977. 
AB  - Two years ago, at a meeting of the Bulletin's Editorial Board, it was decided to publish an issue devoted to the clinical phenomenology of schizophrenia. The emphasis was to be placed not on static descriptive material but rather on the changes in symptoms and clinical course that appear to have occurred over the past 75 years. It seemed reasonable to expect that the major developments in the treatment of schizophrenia would have had a significant impact on its clinical course; psychotropic drugs and 'deinstitutionalization' to cite the most obvious factors. Moreover, many clinicians had reported their impressions of changes in the clinical phenomenology of schizophrenia; e.g., the virtual disappearance of the catatonic subtype. It was not clear, however, whether it was possible to document more precisely what changes had occurred, and whether it was possible to relate the changes to specific causative factors. Nor was it clear to what degree the impression of change was the result of a changing observational vantage point. The manuscripts collected herein are intended to provide a perspective on this complex issue. Unfortunately, there is not even general agreement as to what schizophrenia is today, no less what it was in 1900. Nevertheless, some general agreement emerges that there has been a gradual change in the course of the disorder as well as a gradual change in the observer, and perhaps a more abrupt change in societal management of the schizophrenic. The complex interrelationships of these variables become apparent as one reads the manuscripts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical phenomenology
KW  - psychotropic drugs
KW  - schizophrenia
KW  - deinstitutionalization
KW  - observers' perspectives
KW  - 1977
KW  - Schizophrenia
KW  - Deinstitutionalization
KW  - Drug Therapy
KW  - 1977
DO  - 10.1093/schbul/3.4.528
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09713-010
AN  - 2005-09713-010
AU  - Bartko, John J.
AU  - Carpenter, William T. Jr.
T1  - The masks of insanity: A graphics tool for the summarization of psychiatric data.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1977///
VL  - 3
IS  - 4
SP  - 632
EP  - 637
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Bartko, John J., NIMH, Bldg. 36, Rm. 1D24, 9000 Rockville Pike, Bethesda, MD, US, 20014
N1  - Accession Number: 2005-09713-010. PMID: 339333 Partial author list: First Author & Affiliation: Bartko, John J.; Division of Biometry and Epidemiology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20060306. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Computer Applications; Face (Anatomy); Graphical Displays; Mental Disorders; Psychiatric Symptoms. Minor Descriptor: Data Collection; Facial Features; Psychopathology; Statistical Analysis. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1977. 
AB  - This article discusses visual presentation of sign and symptom data. By using graphic techniques to communicate precise data visually, the observer will be able to grasp the concept and the specific information simultaneously. A profile of psychopathologic dimensions is most often presented in terms of a plot, a device for easing the reader's absorption of a great deal of material. The most common statistical graphics device used to summarize a patient's symptom profile is a data plot in the two-dimensional rectangular coordinate system. Statistical graphics is not a new technique, but, when used in conjunction with computer technology, it may provide a promising tool for data display in psychiatric settings. Computers can be programmed to provide various forms of graphics, including humanoid forms. Both the standard two-dimensional rectangular coordinate system profile plot and the face convey the same information. Today's reader is surely familiar with profile plots, but how is the facial expression to be interpreted? A graphics face contrasted to the rectangular coordinate profile plot may facilitate the comprehension of differences as well as similarities among patients and patient groups. Incorporating mnemonic devices between facial features and psychopathologic dimensions will aid in this regard. Such facial representations of psychiatric data may have a place in clinical records. As the clinician learns to read the face in terms of the correspondence between facial features and symptom dimensions, this graphics device may serve as a quick refresher of the clinical state/impression of the patient, not to mention its usefulness in following the course of illness over time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric data
KW  - clinical data
KW  - psychopathology
KW  - facial features
KW  - graphics tool
KW  - statistical graphics
KW  - 1977
KW  - Computer Applications
KW  - Face (Anatomy)
KW  - Graphical Displays
KW  - Mental Disorders
KW  - Psychiatric Symptoms
KW  - Data Collection
KW  - Facial Features
KW  - Psychopathology
KW  - Statistical Analysis
KW  - 1977
DO  - 10.1093/schbul/3.4.632
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - QUENZER, L. F.
AU  - GALLI, C. L.
AU  - NEFF, N. H.
T1  - Activation of the Nigrostriatal Dopaminergic Pathway by Injection of Cholera Enterotoxin into the Substantia Nigra.
JO  - Science
JF  - Science
Y1  - 1977/01/07/
VL  - 195
IS  - 4273
M3  - Article
SP  - 78
EP  - 80
SN  - 00368075
AB  - Twenty-four hours after unilateral injection of cholera enterotoxin into the rat substantia nigra there is an increase, in the striatum on the injected side, of basal adenylate cyclase activity, 3,4-dihydroxyphenylacetic acid, and 3-methoxy4- hy-droxyphenylacetic acid. Moreover, there is an increase of motor activity, and rats tend to circle contralateral to the side of the injection. Injection of cholera enterotoxin into brain nuclei may be a useful procedure for pharmacologically activating selected neuronal systems of brain and for studying the pharmacology of drugs that are suspected of interacting with these systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361399; QUENZER, L. F. 1; GALLI, C. L. 1; NEFF, N. H. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/ 7/1977, Vol. 195 Issue 4273, p78; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VARMA, S. D.
AU  - MIZUNO, A.
AU  - KINOSHITA, J. H.
T1  - Diabetic Cataracts and Flavonoids.
JO  - Science
JF  - Science
Y1  - 1977/01/14/
VL  - 195
IS  - 4274
M3  - Article
SP  - 205
EP  - 206
SN  - 00368075
AB  - Oral administration of quercitrin, an inhibitor of aldose reductase, leads to a significant decrease in the accumulation of sorbitol in the lens of diabetic Octodon degus. The onset of cataract is effectively delayed when quercitrin is continuously administered. Thus in these diabetic animals, as in galactosemic rats, the use of an effective aldose reductase inhibitor impedes the course of cataract development. These observations support the hypothesis that in diabetes, as in galactosemia, aldose reductase plays a key role in initiating the formation of lens opacity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361447; VARMA, S. D. 1; MIZUNO, A. 1; KINOSHITA, J. H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; Issue Info: 1/14/1977, Vol. 195 Issue 4274, p205; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Heller, S. R.
AU  - Milne, G. W. A.
AU  - Feldmann, R. J.
T1  - A Computer-Based Chemical Information System.
JO  - Science
JF  - Science
Y1  - 1977/01/21/
VL  - 195
IS  - 4275
M3  - Article
SP  - 253
EP  - 259
SN  - 00368075
N1  - Accession Number: 85218262; Heller, S. R. 1; Milne, G. W. A. 2; Feldmann, R. J. 3; Affiliations: 1: Computer specialist, Management, Information Data Systems Division, Environmental Protection Agency, Washington, D.C. 20460; 2: Research chemist, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 3: Computer specialist, Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/21/1977, Vol. 195 Issue 4275, p253; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - POSTON, J. MICHAEL
T1  - Leucine 2,3-Aminomutase: A Cobalamin-Dependent Enzyme Present in Bean Seedlings.
JO  - Science
JF  - Science
Y1  - 1977/01/21/
VL  - 195
IS  - 4275
M3  - Article
SP  - 301
EP  - 302
SN  - 00368075
AB  - Leucine 2,3-aminomutase has been demonstrated in extracts of bean seedlings. The activity of this enzyme is stimulated by coenzyme B12 and is inhibited by intrinsic factor. The inhibition is removed by the addition of coenzyme B12. This evidence is consistent with the presence of a cobalamin-dependent enzyme in higher plants. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218284; POSTON, J. MICHAEL 1; Affiliations: 1: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/21/1977, Vol. 195 Issue 4275, p301; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CARTER, RICHARD
AU  - NIJHOUT, MARY M.
T1  - Control of Gamete Formation (Exflagellation) in Malaria Parasites.
JO  - Science
JF  - Science
Y1  - 1977/01/28/
VL  - 195
IS  - 4276
M3  - Article
SP  - 407
EP  - 409
SN  - 00368075
AB  - The only stages of malaria parasites capable of establishing an infection in a mosquito are the gametocytes that circulate in the blood of the vertebrate host. Within minutes of ingestion by a mosquito the gametocytes transform into mature gametes in the process of "exflagellation." This process is controlled in vitro solely by the change in pH in the blood as it moves from the environment of the circulation to that of the atmosphere, the pH rise being mediated by the fall in carbon dioxide tension as the blood equilibrates with the atmosphere. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218321; CARTER, RICHARD 1; NIJHOUT, MARY M. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 1/28/1977, Vol. 195 Issue 4276, p407; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Hoff, D. D.;
AU  - Rozencweig, M.;
AU  - Layard, M.;
AU  - Slavik, M.;
AU  - Muggia, F. M.;
T1  - Daunomycin induced cardiotoxicity in children and adults
CT  - Daunomycin induced cardiotoxicity in children and adults
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1977/02/01/
VL  - 62
IS  - Feb
SP  - 200
EP  - 208
SN  - 00029343
AD  - Investigational Drug Branch, Building 37, Room 6E12, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-3421; Language: English; Trade Name: Daunomycin; Generic Name: Daunorubicin; Chemical Name: Daunorubicin--20830-81-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin; References: 25; Journal Coden: AJMEAZ; Human Indicator: Yes; Section Heading: Toxicity
N2  - Reports on 5,613 patients receiving daunomycin (daunorubicin; I) were reviewed for cardiotoxicity. Two distinct patterns of cardiotoxicity were determined, congestive heart failure (cardiomyopathy) and ECG changes. Construction of a dose response curve using the percent incidence of cardiomyopathy versus the total dose of I in mg/sq m revealed a dose response relationship between the total dose of I and the development of cardiomyopathy in children and adults. The ECG changes in children and adults did not show a dose dependent relationship. These ECG changes were present consistently even at lowest dosage levels. The dose response curves constructed enable the clinician to judge the relative risk of developing cardiomyopathy at a given total dose of I.
KW  - Daunorubicin--toxicity-;
KW  - Toxicity--daunorubicin--studies, cardiac, correlation to dosage, children and adults;
KW  - Antineoplastic agents--daunorubicin--toxicity, studies, cardiac, correlation to dosage, children and adults;
KW  - Dosage--daunorubicin--correlations, cardiotoxicity, children and adults;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jasinski, D. R.;
AU  - Pevnick, J. S.;
AU  - Clark, S. C.;
AU  - Griffith, J. D.;
T1  - Therapeutic usefulness of propoxyphene napsylate in narcotic addiction
CT  - Therapeutic usefulness of propoxyphene napsylate in narcotic addiction
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1977/02/01/
VL  - 34
IS  - Feb
SP  - 227
EP  - 233
AD  - Addiction Research Center, National Institute on Drug Abuse, P.O. Box 12390, Lexington, Kentucky 40511
N1  - Accession Number: 14-5530; Language: English; Trade Name: Darvon--Dolene--SK-65--Darvon-N; Generic Name: Propoxyphene; Propoxyphene; Propoxyphene; Propoxyphene napsylate; Chemical Name: Propoxyphene--469-62-5 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 22; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Ronald E. Nagata
N2  - The toxicity that limits the abuse potential of propoxyphene napsylate (Darvon-N; I) also limits its usefulness as a therapeutic agent in treating narcotic addiction as shown in a double blind crossover study with 9 volunteers who received gelatin capsules of I, or propoxyphene HCl (Darvon; Dolene; SK-65), SC morphine sulfate, oral placebo and SC placebo in a random order at weekly intervals. The relative potency of I in producing miosis, morphine like subjective effects and euphoria in man was determined. Oral I, 50 to 60 mg, is equivalent to 1 mg of SC morphine.
KW  - Propoxyphene--hydrochloride, comparison, napsylate-;
KW  - Morphine--dependence-;
KW  - Toxicity--propoxyphene--hydrochloride, comparison, napsylate, therapy, narcotic addiction, humans;
KW  - Dependence--morphine--therapy, propoxyphene salts, humans;
KW  - Analgesics and antipyretics--morphine--dependence, therapy, propoxyphene salts, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Tormey, D. C.;
AU  - Simon, R.;
AU  - Falkson, G.;
AU  - Bull, J.;
AU  - Band, P.;
AU  - \ET/;
T1  - Evaluation of adriamycin and dibromodulcitol in metastatic breast carcinoma
CT  - Evaluation of adriamycin and dibromodulcitol in metastatic breast carcinoma
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1977/02/01/
VL  - 37
IS  - Feb
SP  - 529
EP  - 534
SN  - 00085472
AD  - Medical Breast Cancer Section, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-3137; Language: English; Trade Name: Dibromodulcitol--NSC-104800; Generic Name: Mitolactol; Mitolactol; Chemical Name: Doxorubicin--23214-92-8 Mitolactol--10318-26-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin and mitolactol (10:00); AHFS Class: Antineoplastic agents mitolactol and doxorubicin; References: 8; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - A Phase 1 to 2 evaluation of a combination of adriamycin (doxorubicin; I) and dibromodulcitol (mitolactol; NSC-104800; II) was performed in patients with progressive, metastatic breast carcinoma. All but one patient had been treated previously with chemotherapy. I was given on day one or days one and 8, and II was given on days one to 10 of each 21 to 28 day treatment cycle. Side effects were evaluable in 54 patients, and 50 patients were evaluable for therapeutic response. The dose limiting toxicities were leukopenia and thrombocytopenia. The severity of both toxicities increased as both the I and II doses increased; however, the effect of increases in II dose was much more profound. The mean white blood cell count and platelet nadirs occurred, respectively, on days 15.3 and 15.9; both nadirs were delayed for 0.6 day by each 30 mg/sq m/day increase in the II dose and delayed for 1.7 to 3.9 days using the day one, 8 rather than the day one I schedule. Recovery of the peripheral counts by day 29 was prolonged by the day one, 8, I schedule and by increasing the II dose. A tolerable dose schedule for previously treated patients was considered to be I, 40 mg/sq m on day one, and II, 135 mg/sq m on days one to 10 repeated every 28 days. Responses were observed in 46% (23 of 50) of the patients. There were; one complete remission, 19 partial remissions, and 3 improvements. Thirteen patients showed no change and 14 developed progressive disease. There were responses in 13 of 37 (36%) with visceral dominant disease as compared to 7 of 8 (87%) with osseous and 3 of 5 (60%) with soft tissue dominant disease. There were 22 of 48 (46%) responses in patients previously exposed to alkylating agent therapy. Twenty-two patients had responded and 19 had failed to respond to prior alkylating agent containing regimens; the response rates to II in these groups were, respectively, 45 and 42%. The median time to remission was 29 days. The median time to therapeutic failure was 5.1 months for responders, 2.3 months for patients with no change, and 29 days for progressors. The combination of I and II appears to be an active and well tolerated program in patients with previously treated metastatic breast carcinoma.
KW  - Doxorubicin--and mitolactol-;
KW  - Mitolactol--and doxorubicin-;
KW  - Antineoplastic agents--doxorubicin and mitolactol--carcinomas, metastatic breast, dosage, side effects, and therapy, patients;
KW  - Antineoplastic agents--mitolactol and doxorubicin--carcinomas, metastatic breast, dosage, side effects, and therapy, patients;
KW  - Combined therapy--doxorubicin and mitolactol--carcinomas, metastatic breast, dosage, and side effects, patients;
KW  - Combined therapy--mitolactol and doxorubicin--carcinomas, metastatic breast, dosage, and side effects, patients;
KW  - Dosage--doxorubicin and mitolactol--carcinomas, metastatic breast, therapy, and side effects, patients;
KW  - Dosage--mitolactol and doxorubicin--carcinomas, metastatic breast, therapy, and side effects, patients;
KW  - Toxicity--doxorubicin and mitolactol--side effects, metastatic breast carcinoma, dosage, and therapy, patients;
KW  - Toxicity--mitolactol and doxorubicin--side effects, metastatic breast carcinoma, dosage, and therapy, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Straus, M. J.;
AU  - Straus, S. E.;
AU  - Batiste, L.;
AU  - Krezoski, S.;
T1  - Uptake, excretion, and radiation hazards of tritiated thymidine in humans
CT  - Uptake, excretion, and radiation hazards of tritiated thymidine in humans
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1977/02/01/
VL  - 37
IS  - Feb
SP  - 610
EP  - 618
SN  - 00085472
AD  - Cell Kinetics Lab., National Cancer Institute-V.A. Hospital, Washington, D.C. 20422
N1  - Accession Number: 14-3331; Language: English; Chemical Name: Thymidine--50-89-5; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals thymidine; References: 43; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2  - Nine patients with malignant disease were given IV tritiated thymidine (I), 0.2 mCi/kg, for tumor cell kinetics studies. Serial plasma, urine, saliva, and air vapor samples were collected variously for up to 79 days, and tritium activity was measured. The initial half-life of plasma activity was rapid. After one day, the activity decayed with a half-life of 10.8 days, indicating equilibration of activity with the total body water. Urine activity was over 100 times the plasma activity within one hr, with equilibration approaching the plasma activity after 2 days, and then decayed at a similar rate. Saliva and air vapor activity increased to plasma levels and then decayed at the same rate as did plasma activity. In the first 24 hr, approximately 33% of the total injected activity was excreted in the urine. During the first 12 days there were 54.2% urinary and 10.6% insensible losses. Maximum losses determined by extrapolation of observed data were 68% urinary and 19.5% insensible losses, or a total of 87.5%. Approximately 7% of the injected activity may represent material initially incorporated into DNA but later metabolized and excreted. The radiation dose from total body water is estimated at 0.69 rad. The estimated dose absorbed by cell nuclei from incorporated material is a maximum of 20.5 rads. These radiation doses would not seem to contraindicate injection of 0.2 mCi/kg tritiated I to patients. Measurements of activity in personnel and room air indicate that the use of such doses is not hazardous if appropriate precautions are followed.
KW  - Thymidine--tritiated-;
KW  - Pharmacokinetics--thymidine--tritiated, radiation hazards, cancer patients;
KW  - Blood levels--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW  - Excretion--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW  - Saliva levels--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW  - Half-life--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW  - Radiopharmaceuticals--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW  - Toxicity--thymidine--tritiated, radiation hazards, pharmacokinetics, cancer patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Stylos, W. A.
AU  - Rose, N. R.
T1  - Splitting of human thyroglobulin IV. THE ANTIGENICITY OF THE PEPSIN--DERIVED FRAGMENTS.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1977/02//
VL  - 27
IS  - 2
M3  - Article
SP  - 245
EP  - 253
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Purified human thyroglobulin (Tg) was hydrolysed by pepsin. After completion of hydrolysis the pepsin hydrolysate was passed through a Sephadex G-200 column to remove undigested Tg. Further isolation of the enzymatic fragments was effected by passage through a Sephadex G-75 column. Two discrete fragments, termed pep I and pep I I, were separated. The two fragments had sedimentation coefficients of l.0 and 0.6, respectively. These fragments retained antigenic determinants reactive with both hetero- and auto-antibodies to Tg. The larger fragment, pep 1. possessed all antigenic determinants to intact Tg while pep II lacked some determinants. Neither fragment contained novel determinants resulting from proteolytic degradation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYROGLOBULIN
KW  - PEPSIN
KW  - ANTIGENS
KW  - DEXTRAN
KW  - ION exchange (Chemistry)
KW  - ANTIGENIC determinants
N1  - Accession Number: 16075830; Stylos, W. A. 1,2 Rose, N. R. 2,3; Affiliation:  1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Department of Microbiology, State University of New York, Buffalo, Buffalo, New York, U.S.A.  3: Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, 48201, U.S.A.; Source Info: Feb1977, Vol. 27 Issue 2, p245; Subject Term: THYROGLOBULIN; Subject Term: PEPSIN; Subject Term: ANTIGENS; Subject Term: DEXTRAN; Subject Term: ION exchange (Chemistry); Subject Term: ANTIGENIC determinants; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donnelly, C. J.
AU  - Thomson, L. A.
AU  - Stiles, H. M.
AU  - Brewer, C.
AU  - Neel, J. V.
AU  - Brunelle, J. A.
T1  - Plaque, caries, periodontal diseases, and acculturation among Yanomamö Indians, Venezuela.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1977/02//
VL  - 5
IS  - 1
M3  - Article
SP  - 30
EP  - 39
SN  - 03015661
AB  - The number of DM and d teeth and surfaces was recorded for 220 Yanomamö, Indians front three groups of villages with different degrees of contact with Western culture. Specimens of plaque were taken from the teeth, transported in a holding solution, cultured, and examined for specific oral streptococci. In addition, the periodontal health and oral hygiene of one group of villagers were assessed using the Russell PI and the Greene & vermillion OHIS. Caries experience among the Yanomamö was shown to be positively associated with exposure to Western culture. S. mutans was recovered with about the same frequency from specimens taken from the teeth of Indians living at all three village locations. However, the presence of S. mutans alone did not account for the disparity in dental caries scores. The examinees had abundant and persistent accumulations of soft deposits on teeth accompanied by markedly inflamed gingival tissues. However, periodontal pockets and loss of appreciable amounts of bone did not appear as early in life nor were they as severe as reported for sonic other populations which practice little oral hygiene. Those disparities in the distribution of plaque-induced oral diseases between Western populations and the Yanomamö warrant further study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERIODONTAL disease
KW  - DENTAL plaque
KW  - DENTAL caries
KW  - TEETH
KW  - ORAL hygiene
KW  - STREPTOCOCCUS
KW  - GUMS
KW  - TISSUES
KW  - YANOMAMO (South American people)
KW  - VILLAGES
KW  - denial caries
KW  - dental plaque
KW  - Indians
KW  - periodontal disease
N1  - Accession Number: 12103459; Donnelly, C. J. 1 Thomson, L. A. 2 Stiles, H. M. 2 Brewer, C. 3 Neel, J. V. 4 Brunelle, J. A. 2; Affiliation:  1: Johns Hopkini University School of Hygiene and Public Health, Department of Health Services Administration 615 N. Wolfe Street Baltimore, Maryland 21205 U.S.A.  2: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014 U.SA.  3: Edificio Galipan Averida Francisco Miranda Caracas Venezuela.  4: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, U.S.A.; Source Info: Feb1977, Vol. 5 Issue 1, p30; Subject Term: PERIODONTAL disease; Subject Term: DENTAL plaque; Subject Term: DENTAL caries; Subject Term: TEETH; Subject Term: ORAL hygiene; Subject Term: STREPTOCOCCUS; Subject Term: GUMS; Subject Term: TISSUES; Subject Term: YANOMAMO (South American people); Subject Term: VILLAGES; Author-Supplied Keyword: denial caries; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: Indians; Author-Supplied Keyword: periodontal disease; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1600-0528.ep12103459
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Krause, R. M.;
T1  - Prevention through immunization: new opportunities or end of the road?
CT  - Prevention through immunization: new opportunities or end of the road?
JO  - Journal of Infectious Diseases (USA)
JF  - Journal of Infectious Diseases (USA)
Y1  - 1977/02/01/
VL  - 135
IS  - Feb
SP  - 318
EP  - 329
SN  - 00221899
AD  - National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland
N1  - Accession Number: 14-5658; Language: English; References: 42; Publication Type: Review; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Pharmacology; MicrobiologyDrug EvaluationsSociology, Economics and Ethics; Abstract Author: Robert Barger
N2  - This review article discussed the prospects for human immunization for group A streptococcal, gonococcal, pneumococcal and meningococcal infections and immunization with purified bacterial polysaccharide.
KW  - Immunization--infections--group A streptococcus, gonococcus, pneumococcus, meningococcus, immunogenetics, polysaccharide capsular vaccines, review, humans;
KW  - Vaccines--immunization--infections, group A streptococcus, gonococcus, pneumococcus, meningococcus, immunogenetics, polysaccharide capsular, review, humans;
KW  - Polysaccharides--bacterial--vaccines, S. pneumonia, N. meningitis, H. influenza, review, humans;
KW  - Gonococcus--infections--immunization, review, humans;
KW  - Streptococcus--infections--immunization, review, humans;
KW  - Pneumococcus--infections--immunization, review, humans;
KW  - Meningococcus--infections--immunization, review, humans;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Rölla, Gunnar
AU  - Bowen, William H.
T1  - Concentration of fluoride in plaque--a possible mechanism.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1977/02//Jan/Feb1977
VL  - 85
IS  - 2
M3  - Article
SP  - 149
EP  - 151
SN  - 0029845X
AB  - A mechanism of concentration of fluoride (and phosphate) ions in plaque is suggested: calcium ions from saliva are hound to fixed acidic groups in the plaque, and fluoride (or phosphate) ions are attracted to the bound calcium as counterions. The principle was demonstrated by equilibrium dialysis of calcium-treated acidic ionic exchange material (Sephadex® SP and CM) against 1 part/106 of fluoride. A part of the fluoride was found to be bound under these conditions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL plaque
KW  - DENTAL deposits
KW  - FLUORIDES
KW  - SALIVA
KW  - ORAL microbiology
KW  - EXAMINATION
KW  - <em>dental plaque</em>
KW  - <em>fluorides</em>.
N1  - Accession Number: 13205816; Rölla, Gunnar 1 Bowen, William H. 1; Affiliation:  1: National Caries Program, National institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan/Feb1977, Vol. 85 Issue 2, p149; Subject Term: DENTAL plaque; Subject Term: DENTAL deposits; Subject Term: FLUORIDES; Subject Term: SALIVA; Subject Term: ORAL microbiology; Subject Term: EXAMINATION; Author-Supplied Keyword: <em>dental plaque</em>; Author-Supplied Keyword: <em>fluorides</em>.; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2005-09076-001
AN  - 2005-09076-001
AU  - Wax, Teena M.
T1  - Effects of Age, Strain, and Illumination Intensity on Activity and Self-Selection of Light-Dark Schedules in Mice.
JF  - Journal of Comparative and Physiological Psychology
JO  - Journal of Comparative and Physiological Psychology
JA  - J Comp Physiol Psychol
Y1  - 1977/02//
VL  - 91
IS  - 1
SP  - 51
EP  - 62
CY  - US
PB  - American Psychological Association
SN  - 0021-9940
AD  - Wax, Teena M., c/o Charles Goodrick, Gerontology Research Center, NIA, Baltimore City Hospitals, Baltimore, MD, US, 21224
N1  - Accession Number: 2005-09076-001. PMID: 838917 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Wax, Teena M.; University of Delaware and National Institute on Aging, Baltimore, MD, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Age Differences; Animal Circadian Rhythms; Animal Strain Differences; Illumination. Minor Descriptor: Mice. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Feb, 1977. Copyright Statement: American Psychological Association. 1977. 
AB  - Young and senescent albino A/J mice, pigmented C57BL/6J pure inbred mice, and their hybrid F₁s were tested under low or high illumination intensities to observe differences in self-selected wheel running, bar pressing, and durations of light and dark over time. The animals (N=120) were always allowed ad lib access to food, water, running wheel, and bar-press levers. During the pre- and postexperimental phases, the mice were kept under a standard 12:12 hr light/dark cycle; during the experimental phase, however, they were allowed to select their own light and dark schedules by pressing on either of two accessible bars, one light contingent and the other dark contingent. Measures of general running and bar-pressing activities, motivational aspects of illumination change and intensity preferences, timeseries analyses of periodicities, power ratios, and significant other multiples were obtained from the subjects during a total of three experimental phases. Age differences were found for most of the measures studied and in general showed declines in activity levels, increases in motivation to change illumination conditions, lengthening of activity cycles (slower periods), and decreases in the strengths of the oscillations underlying these behaviors as well as an increase in the number of other periodic components in old mice relative to young. Genetic group and illumination-intensity differences were also found, and the results are discussed in light of theories concerning illumination preference and stimulus change, earlier work involving voluntary light selection behavior, and aging studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - age
KW  - strain differences
KW  - illumination intensities
KW  - activity levels
KW  - self-selected light-dark schedules
KW  - mice
KW  - 1977
KW  - Activity Level
KW  - Age Differences
KW  - Animal Circadian Rhythms
KW  - Animal Strain Differences
KW  - Illumination
KW  - Mice
KW  - 1977
DO  - 10.1037/h0078071
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06295-014
AN  - 2006-06295-014
AU  - Plaut, Thomas F. A.
T1  - Humane Health Care: Traditional and Countercultural Approaches.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1977/02//
VL  - 22
IS  - 2
SP  - 117
EP  - 119
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06295-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Plaut, Thomas F. A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061226. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Health Care Psychology; Humanism; Nursing; Patients; Health Personnel. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Chapman, Jane E.; Chapman, Harry H. Behavior and Health Care: A Humanistic Helping Process=St. Louis, Mo.: Mosby, 1975. Pp. x + 193. $5.50; 1975. Howard, Jan (Ed); Strauss, Anselm (Ed). Humanizing Health Care=New York: Wiley, 1975. Pp. xiii + 326. $14.95; 1975. Page Count: 3. Issue Publication Date: Feb, 1977. 
AB  - Reviews the books, Behavior and Health Care: A Humanistic Helping Process by Jane E. Chapman and Harry H. Chapman (1975) and Humanizing Health Care edited by Jan Howard and Anselm Strauss (1975). These two volumes present strikingly different approaches to a single subject--the dehumanization of health care. Humanizing Health Care also includes contributions by medical economists, political scientists, nurses, and social workers. Behavior and Health Care strongly argues for the importance of health care personnel 'taking care' of themselves and not getting trapped by the detachment that often accompanies professional training and increasing emphasis on technical skills. The Howard and Strauss volume is essentially an academic, analytic, research-oriented effort to explore various aspects of dehumanization and possible remedies. The Chapman and Chapman volume, while also relying heavily on social science and psychological concepts, is written primarily for an audience of nursing students and other health care, workers. Chapman and Chapman, in contrast to Howard and Strauss, emphasize the experiential and emotional aspects of the one-to-one face-to-face interaction between healthcare workers and patients. The two volumes highlight contemporary human problems in health care and stress factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - behavior health care
KW  - humanizing health care
KW  - healthcare workers
KW  - patients
KW  - 1977
KW  - Health Care Psychology
KW  - Humanism
KW  - Nursing
KW  - Patients
KW  - Health Personnel
KW  - 1977
U2  - Chapman, Jane E.; Chapman, Harry H. (1975); Behavior and Health Care: A Humanistic Helping Process; St. Louis, Mo.: Mosby, 1975. Pp. x + 193. $5.50
U2  - Howard, Jan (Ed); Strauss, Anselm (Ed). (1975); Humanizing Health Care; New York: Wiley, 1975. Pp. xiii + 326. $14.95
DO  - 10.1037/034699
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - EVARTS, EDWARD V.
T1  - Normal Motor Behavior.
JO  - Science
JF  - Science
Y1  - 1977/02/04/
VL  - 195
IS  - 4277
M3  - Article
SP  - 482
EP  - 482
SN  - 00368075
N1  - Accession Number: 85218354; EVARTS, EDWARD V. 1; Affiliations: 1: Laboratory of Nelurophysiology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p482; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SPORN, MICHAEL B.
AU  - SQUIRE, ROBERT A.
AU  - BROWN, CHARLES C.
AU  - SMITH, JOSEPH M.
AU  - WENK, MARTIN L.
AU  - SPRINGER, STEPHEN
T1  - 13-cis-Retinoic Acid: Inhibition of Bladder Carcinogenesis in the Rat.
JO  - Science
JF  - Science
Y1  - 1977/02/04/
VL  - 195
IS  - 4277
M3  - Article
SP  - 487
EP  - 489
SN  - 00368075
AB  - Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoic acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218358; SPORN, MICHAEL B. 1; SQUIRE, ROBERT A. 1; BROWN, CHARLES C. 1; SMITH, JOSEPH M. 1; WENK, MARTIN L. 2; SPRINGER, STEPHEN 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Microbiological Associates, Bethesda 20014; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p487; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSTEIN, J. N.
AU  - YOSHIKAMI, S.
AU  - HENKART, P.
AU  - BLUMENTHAL, R.
AU  - HAGINS, W. A.
T1  - Liposome-Cell Interaction: Transfer and Intracellular Release of a Trapped Fluorescent Marker.
JO  - Science
JF  - Science
Y1  - 1977/02/04/
VL  - 195
IS  - 4277
M3  - Article
SP  - 489
EP  - 492
SN  - 00368075
AB  - When small, unilamellar lipid vesicles containing a high concentration of the fluorescent dye 6-carboxyfluorescein are incubated with either frog retinas or human lymphocytes, fluorescence distributes widely throughout each cell. Since "self-quenching" largely prevents the dye from fluorescing as long as it remains sequestered in vesicles, it is clear that a considerable amount of dye is released from the vesicles and diluted into the much larger volume of the cell [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218359; WEINSTEIN, J. N. 1; YOSHIKAMI, S. 2; HENKART, P. 3; BLUMENTHAL, R.; HAGINS, W. A. 4,5; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health,Bethesda, Maryland 20014; 2: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; 3: Immunology Branch, National Cancer Institute; 4: Laboratory of Theoretical Biology, National Cancer Institute; 5: Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p489; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WOOD, JAMES H.
AU  - POPLACK, DAVID G.
AU  - BLEYER, WERNER A.
AU  - OMMAYA, AYUB K.
T1  - Primate Model for Long-Term Study of Intraventricularly or Intrathecally Administered Drugs and Intracranial Pressure.
JO  - Science
JF  - Science
Y1  - 1977/02/04/
VL  - 195
IS  - 4277
M3  - Article
SP  - 499
EP  - 501
SN  - 00368075
AB  - Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinalfluid reservoirs. This model permits sterile access to ventricular cerebrospinalfluid without tissue damage, provides mixing of injected drugs with lateral ventricular cerebrospinal fluid, enables spinoventricular perfusion, and permits ventricular cerebrospinalfluid sampling over extended periods in unanesthetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218364; WOOD, JAMES H. 1; POPLACK, DAVID G. 1; BLEYER, WERNER A. 1; OMMAYA, AYUB K. 1; Affiliations: 1: Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, and Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, and Children's Orthopedic Hospital, Seattle, Washington; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p499; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GALE, K.
AU  - GUIDOTTI, A.
AU  - COSTA, E.
T1  - Dopamine-Sensitive Adenylate Cyclase: Location in Substantia Nigra.
JO  - Science
JF  - Science
Y1  - 1977/02/04/
VL  - 195
IS  - 4277
M3  - Article
SP  - 503
EP  - 505
SN  - 00368075
AB  - A dopamine-sensitive adenylate cyclase with characteristics similar to those measured in the striatum is present in the rat substantia nigra. Destruction of dopamine cell bodies by intranigral 6-hydroxydopamine application failed to abolish the response of nigral adenvlate cyclase to dopamine. In contrast, brain hemitransection between the striatum and substantia nigra, or a more circumscribed lesion of striatonigral pathways, abolished the dopamine stimulation of adenylate cyclase in the substantia nigra. These results suggest that dopamine receptors within the substantia nigra are not located on dopamine cell bodies but are associated with a pathway, containing raminobutyric acid or substance P, which projectsfromforebrain structures to the substantia nigra. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218366; GALE, K. 1; GUIDOTTI, A. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p503; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - JASINSKI, DONALD R.
AU  - NUTT, JOHN G.
AU  - HAERTZEN, CHARLES A.
AU  - GRIFFITH, JOHN D.
AU  - BUNNEY, WILLIAM E.
T1  - Lithium: Effects on Subjective Functioning and Morphine-Induced Euphoria.
JO  - Science
JF  - Science
Y1  - 1977/02/11/
VL  - 195
IS  - 4278
M3  - Article
SP  - 582
EP  - 584
SN  - 00368075
AB  - The therapeutic usefulness of lithium in decreasing the euphoria and other symptoms associated with manic behavior and the hypothesis of a common final mechanism for elevations in mood have led to speculation that lithium may block the euphoria induced by drugs of abuse. In this study, lithium alone was antieuphoric in drug-free opiate addicts and, further, did not block morphine-indu&d euphoria. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003171; JASINSKI, DONALD R. 1; NUTT, JOHN G. 1; HAERTZEN, CHARLES A. 1; GRIFFITH, JOHN D. 1; BUNNEY, WILLIAM E. 2; Affiliations: 1: Addiction Research Center, National Institute on Drug Abuse, Lexington, Kenituckv 40511; 2: Adult Psvchiatrv Branch, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/11/1977, Vol. 195 Issue 4278, p582; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KLASSEN, LYNELL W.
AU  - BUDMAN, DANIEL R.
AU  - WILLIAMS, GARY W.
AU  - STEINBERG, ALFRED D.
AU  - GERBER, N. LYNN
T1  - Ribavirin: Efficacy in the Treatment of Murine Autoimmune Disease.
JO  - Science
JF  - Science
Y1  - 1977/02/25/
VL  - 195
IS  - 4280
M3  - Article
SP  - 787
EP  - 789
SN  - 00368075
AB  - Ribavirin, a drug with known antiviral activity, was given to mice with established lupus nephritis. Ribavirin was effective in prolonging survival, reducing the titer of antibodies to DNA, and reversing proteinuria. Other antiviral agents were not effective in the dosages used. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218396; KLASSEN, LYNELL W. 1; BUDMAN, DANIEL R. 1; WILLIAMS, GARY W. 1; STEINBERG, ALFRED D. 1; GERBER, N. LYNN 1; Affiliations: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, and Rehabilitation Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/25/1977, Vol. 195 Issue 4280, p787; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Devanthan, S.;
AU  - Channabasavanna, S. M.;
T1  - Controlled clinical study with clobazam\M/a new anxiolytic agent
CT  - Controlled clinical study with clobazam\M/a new anxiolytic agent
JO  - Curr. Ther. Res. Clin. Exp.
JF  - Curr. Ther. Res. Clin. Exp.
Y1  - 1977/03/01/
VL  - 21
IS  - Mar
SP  - 361
EP  - 367
AD  - National Institute of Mental Health and Neuro-Sciences, Bangalore 27, India
N1  - Accession Number: 15-0313; Language: English; Chemical Name: Clobazam--22316-47-8; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers clobazam; References: 9; Journal Coden: CTCEA9; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - A double blind placebo controlled clinical trial was undertaken with clobazam (I) in 47 patients with anxiety neurosis. I, at a concentration of 30 to 40 mg daily, was found to be significantly better than placebo at all evaluation periods from day 0 to day 29, on the Hamilton Anxiety Rating Scale. On day 29, therapeutic response with I was 100%, being significantly better than placebo.
KW  - Clobazam--anxiety-;
KW  - Tranquilizers--clobazam--anxiety, therapy, neurotic patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Salokangas, Anneli
AU  - Talmadge, Kenneth
AU  - Bechtel, Elke
AU  - Eppenberger, Urs
AU  - Chrambach, Andreas
T1  - Calf-Ovary Protein Kinases Dependent on Adenosine 3′:5′ - Monophosphate.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1977/03//3/1/77
VL  - 73
IS  - 2
M3  - Article
SP  - 401
EP  - 409
PB  - Wiley-Blackwell
SN  - 00142956
AB  - High resolving power and quantitative application of polyacrylamide-gel electrophoresis at various pore sizes and electrofocusing provide resolution of a calf-ovarian protein-kinase system at an increased level of magnification, as well as optimal preparative routes. Three protein kinases dependent on adenosine 3′:5′-monophosphate are distinguished by polyacrylamide gel electrophoresis in calf ovarian cytosol. These enzymes which are observed in the pH range 7.5–10.2, appear to be aggregates of a common subunit or monomer. The three kinases are, by the criteria of polyacrylamide gel electrophoresis, distinct from three adenosine-3′:5′-monophosphate-binding proteins found in the calf ovarian system. Analysis by electrofocusing on polyacrylamide gel shows that conventionally purified preparations of the major kinase of cytosol contain an overwhelming majority of contaminant proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYCLIC adenylic acid
KW  - ADENOSINE
KW  - PROTEIN kinases
KW  - CYCLIN-dependent kinases
KW  - POLYACRYLAMIDE gel electrophoresis
KW  - CYTOSOL
KW  - MONOMERS
KW  - ENDOCRINOLOGY
N1  - Accession Number: 13723691; Salokangas, Anneli 1,2 Talmadge, Kenneth 1,2 Bechtel, Elke 1,2 Eppenberger, Urs 1,2 Chrambach, Andreas 1,2; Affiliation:  1: Hormone Laboratory and Experimental Endocrinology, Department of Gynecology, University Clinical Medical School, Basel  2: Reproduction Research Branch, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 3/1/77, Vol. 73 Issue 2, p401; Subject Term: CYCLIC adenylic acid; Subject Term: ADENOSINE; Subject Term: PROTEIN kinases; Subject Term: CYCLIN-dependent kinases; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: CYTOSOL; Subject Term: MONOMERS; Subject Term: ENDOCRINOLOGY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sobieszlk, Apolinary
T1  - Ca-Linked Phosphorylation of a Light Chain of Vertebrate Smooth-Muscle Myosin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1977/03//3/1/77
VL  - 73
IS  - 2
M3  - Article
SP  - 477
EP  - 483
PB  - Wiley-Blackwell
SN  - 00142956
AB  - In vertebrate smooth muscle actomyosin and myofibrils a myosin light chain of molecular weight about 20000 becomes phosphorylated at the same Ca2+ concentration as required to stimulate the actin-activated ATPase activity of myosin. Further, the degree of phosphorylation in the preparations as well as in various reconstituted actomyosins is proportional to their measured Ca2+ sensitivity. The phosphorylation process is very rapid and is essentially completed before the rise in ATPase activity. The enzyme responsible for the observed myosin phosphorylation is a specific myosin light chain kinase which is routinely co-purified with myosin. This kinase is normally present in actomyosin and its removal together with tropomyosin leads to a complete loss of the actin-activated ATPase activity. It is suggested that the Ca-dependent phosphorylation of the light chain via the light chain kinase represents the initial step in the activation of myosin that leads to contraction. Relaxation is probably effected by an as yet uncharacterised light chain phosphatase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MYOSIN
KW  - ACTOMYOSIN
KW  - MUSCLE proteins
KW  - MYOSIN antibodies
KW  - CHEMICAL reactions
KW  - PHOSPHORYLATION
KW  - SMOOTH muscle
KW  - BENZENE
N1  - Accession Number: 13723827; Sobieszlk, Apolinary 1,2; Affiliation:  1: Department of Molecular Biology, University of Aarhus  2: Section on Molecular Cardiology, Cardiology Branch, National Heart, Lung and Bloob Institute National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA; Source Info: 3/1/77, Vol. 73 Issue 2, p477; Subject Term: MYOSIN; Subject Term: ACTOMYOSIN; Subject Term: MUSCLE proteins; Subject Term: MYOSIN antibodies; Subject Term: CHEMICAL reactions; Subject Term: PHOSPHORYLATION; Subject Term: SMOOTH muscle; Subject Term: BENZENE; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Barrows, Charles H.
T1  - Nutrition and aging: The time has come to move from laboratory research to clinical studies.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1977/03//
VL  - 32
IS  - 3
M3  - Editorial
SP  - 39
EP  - 41
SN  - 0016867X
N1  - Accession Number: 17266246; Barrows, Charles H. 1; Source Information: Mar1977, Vol. 32 Issue 3, p39; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1131
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Gershwin, M.E.
AU  - Merchant, B.
AU  - Steinberg, A.D.
T1  - The effects of synthetic polymeric agents on immune responses of nude mice.
JO  - Immunology
JF  - Immunology
Y1  - 1977/03//
VL  - 32
IS  - 3
M3  - Article
SP  - 327
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Investigates the influence of synthetic polymeric agents on the immune responsiveness of congenitally athymic nude mice by determining the effects of in vivo treatment with polynucleotides and polymeric haptenated antigens on splenic theta-bearing cells.  Cell responses to thymic dependent and thymic independent antigens; Absence of acquisition of improved T-cell function in nude mice.
KW  - IMMUNE response
KW  - NUDE mouse
KW  - POLYMERS
KW  - NUCLEIC acids
N1  - Accession Number: 11161102; Gershwin, M.E. 1,2 Merchant, B. 1,2 Steinberg, A.D. 1,2; Affiliation:  1: Department of Medicine, University of California at Davis  2: Immunology Branch, Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration and the Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Maryland; Source Info: Mar77, Vol. 32 Issue 3, p327; Subject Term: IMMUNE response; Subject Term: NUDE mouse; Subject Term: POLYMERS; Subject Term: NUCLEIC acids; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thomas, Donald G.
AU  - Gart, John J.
T1  - A Table of Exact Confidence Limits for Differences and Ratios of Two Proportions and Their Odds Ratios.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1977/03//
VL  - 72
IS  - 357
M3  - Article
SP  - 73
SN  - 01621459
AB  - A table of exact 95 percent confidence limits for differences and ratios of two proportions and their odds ratio, including one-tailed P values for the Fisher-Irwin exact test, is given for a wide variety of 2 x 2 tables with sample sizes of 20(20)100. The calculations are based on Fisher's [3] conditional theory, and the computer algorithm of Thomas [10 or 11] is used to produce the tables. It is shown how the tables may be used for sample size determination without fixing the power for a given alternative hypothesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SAMPLING (Statistics)
KW  - ALGORITHMS
KW  - ECONOMICS -- Statistical methods
KW  - ECONOMETRICS
KW  - CONFIDENCE intervals
KW  - RATIO & proportion
KW  - SAMPLE size (Statistics)
KW  - CONDITIONAL expectations (Mathematics)
KW  - DIFFERENCE equations
KW  - Comparison of proportions
KW  - Con- fidence limits
KW  - Fisher-Irwin exact test.
KW  - Odds ratios
KW  - Sample size determination
KW  - Two-by-two tables
N1  - Accession Number: 4606651; Thomas, Donald G. 1; Gart, John J. 2; Affiliations: 1: Mathematical Statistician and Applied Mathematics Section, Biometry Branch, National Cancer Institute, Laudow Building, Room C-318, Bethesda, MD 20014.; 2: Head, Mathematical Statistics and Applied Mathematics Section, Biometry Branch, National Cancer Institute, Laudow Building, Room C-318, Bethesda, MD 20014.; Issue Info: Mar1977, Vol. 72 Issue 357, p73; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: ALGORITHMS; Thesaurus Term: ECONOMICS -- Statistical methods; Thesaurus Term: ECONOMETRICS; Subject Term: CONFIDENCE intervals; Subject Term: RATIO & proportion; Subject Term: SAMPLE size (Statistics); Subject Term: CONDITIONAL expectations (Mathematics); Subject Term: DIFFERENCE equations; Author-Supplied Keyword: Comparison of proportions; Author-Supplied Keyword: Con- fidence limits; Author-Supplied Keyword: Fisher-Irwin exact test.; Author-Supplied Keyword: Odds ratios; Author-Supplied Keyword: Sample size determination; Author-Supplied Keyword: Two-by-two tables; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Gillette, James R.
AU  - Pohl, Lance R.
T1  - A prospective on covalent binding and toxicity.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1977/03//
VL  - 2
IS  - 4
M3  - Article
SP  - 849
EP  - 871
SN  - 00984108
AB  - In this paper are discussed (1) the three general mechanisms by which radioisotopes may be retained in animal tissues long after labeled drugs are administered, (2) ways of differentiating these mechanisms, and (3) possible relationships between the toxic effects of drugs and their metabolism. It is emphasized, however, that studies on the disposition of drugs should be coordinated with toxicity studies in order to make the results of bioavailability and pharmacokinetic studies more meaningful in setting limits for food residues. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75456801; Gillette, James R. 1 Pohl, Lance R. 2; Affiliation:  1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20014  2: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Mar1977, Vol. 2 Issue 4, p849; Number of Pages: 23p; Document Type: Article
L3  - 10.1080/15287397709529484
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thorgeirsson, Snorri S.
AU  - Wirth, Peter J.
T1  - Covalent binding of foreign chemicals to tissue macromolecules.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1977/03//
VL  - 2
IS  - 4
M3  - Article
SP  - 873
EP  - 881
SN  - 00984108
AB  - In vivo and in vitro covafent binding of foreign chemicals to tissue macromolecules via metabolic activation is described, using the analgesic acetaminophen as an example. Acetaminophen is metabolized through a variety of pathways. The arylating metabolite is formed by a cytochrome P‐450 dependent N‐hydroxylation process. The resulting hydroxamic acid is then conjugated with glutathione, and the resulting conjugate is subsequently excreted as the mercapturic acid in the urine. It is not until the glutathione concentration is reduced to about 20% of the initial concentration that covalent binding of acetaminophen to amino acids of proteins occurs and subsequent liver necrosis is seen. The extent of in vitro binding correlates with treatments that alter hepatic necrosis and in vivo binding, indicating that in vitro binding is a valid index of acetaminophen hepatotoxicity. A simple bacterial test system for detecting chemical carcinogens as mutagens is described. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75456802; Thorgeirsson, Snorri S. 1 Wirth, Peter J. 2; Affiliation:  1: Section on Molecular Toxicology, Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Laboratory of Chemical Pharmacology, National Cancer Institute, Building 37, Room 5C‐30, Bethesda, Maryland, 20014  2: Section on Molecular Toxicology, Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Mar1977, Vol. 2 Issue 4, p873; Number of Pages: 9p; Document Type: Article
L3  - 10.1080/15287397709529485
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Levy, R. I.;
T1  - What you should know about managing hypertension
CT  - What you should know about managing hypertension
JO  - Pharmacy Times (USA)
JF  - Pharmacy Times (USA)
Y1  - 1977/03/01/
VL  - 43
IS  - Mar
SP  - 41
EP  - 45
SN  - 00030627
AD  - National Institutes of Health, Bethesda, Maryland
N1  - Accession Number: 14-4171; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacology; Abstract Author: Walter F. Stanaszek
N2  - The chemotherapeutic management of hypertension is discussed including basic dosage recommendations for antihypertensive regimens and dose ranges for oral diuretics and rauwolfia drugs. Pharmacist involvement in terms of detection, review of medication instructions, reinforcement of physician advice, drug therapy surveillance and refill follow-up programs in the treatment of hypertension is briefly discussed.
KW  - Hypotensive agents--therapy--dosage, and role of pharmacists in patient management;
KW  - Dosage--hypotensive agents--therapy, and role of pharmacists in patient management;
KW  - Pharmacists--hypotensive agents--role, in therapy, and patient management;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2006-06296-039
AN  - 2006-06296-039
AU  - Usdin, Earl
T1  - Old Wine in a New Bottle.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1977/03//
VL  - 22
IS  - 3
SP  - 210
EP  - 211
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06296-039. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Usdin, Earl; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Interactions; Drug Therapy; Drugs; Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Simpson, Lance L. (Ed). Drug Treatment of Mental Disorders=New York: Raven Press, 1976. Pp. x + 323. $13.50; 1976. Page Count: 2. Issue Publication Date: Mar, 1977. 
AB  - Reviews the book, Drug Treatment of Mental Disorders edited by Lance L. Simpson (1976). The book is divided into four sections, three of them devoted to the treatment of mental disorders: psychoses, anxiety, affective disorders. On the positive side, most of the drug chapters have a very useful summary with information on generic and trade names as well as the recommended daily dosage range. On the negative side, most of the drug chapters have very weak sections on metabolism; there are no indications of what metabolites have been found for individual drugs, nor which metabolites are active. The four special topics chapters cover pediatrics, geriatrics, adverse reactions, and drug interactions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug treatment
KW  - mental disorders
KW  - drug interactions
KW  - drug psychology
KW  - 1977
KW  - Drug Interactions
KW  - Drug Therapy
KW  - Drugs
KW  - Mental Disorders
KW  - 1977
U2  - Simpson, Lance L. (Ed). (1976); Drug Treatment of Mental Disorders; New York: Raven Press, 1976. Pp. x + 323. $13.50
DO  - 10.1037/015810
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - BREM, STEVEN S.
AU  - GULLINO, PIETRO M.
AU  - MEDINA, DANIEL
T1  - Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia.
JO  - Science
JF  - Science
Y1  - 1977/03/04/
VL  - 195
IS  - 4281
M3  - Article
SP  - 880
EP  - 882
SN  - 00368075
AB  - Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85198863; BREM, STEVEN S. 1; GULLINO, PIETRO M. 1; MEDINA, DANIEL 2; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; 2: Department of Cell Biology, Baylor College of Medicine, Houston, Texas; Issue Info: 3/ 4/1977, Vol. 195 Issue 4281, p880; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TULLY, JOSEPH G.
AU  - WHITCOMB, ROBERT F.
AU  - CLARK, H FRED
AU  - WILLIAMSON, DAVID L.
T1  - Pathogenic Mycoplasmas: Cultivation and Vertebrate Pathogenicity of a New Spiroplasma.
JO  - Science
JF  - Science
Y1  - 1977/03/04/
VL  - 195
IS  - 4281
M3  - Article
SP  - 892
EP  - 894
SN  - 00368075
AB  - A spiroplasma recovered from allantoic fluids of chick embryos infected with the tick-derived suckling mouse cataract agent was grown in continuous passage on a new artificial culture medium. The cultured organisms inducedtypical ocular and other disease symptoms in susceptible animals, and werereisolated from involved host tissues. Although spiroplasmas have been previously recognized as plant and insect pathogens, this is the first spiroplasma shown to multiply at 37°C and to be pathogenic for vertebrates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85198869; TULLY, JOSEPH G. 1; WHITCOMB, ROBERT F. 2; CLARK, H FRED 3; WILLIAMSON, DAVID L. 4; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Plant Protection Institute, Agriculture Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705; 3: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 4: Department of Anatomical Sciences, State University of New York, Stony Brook 11794; Issue Info: 3/ 4/1977, Vol. 195 Issue 4281, p892; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GAIL, MITCHELL
T1  - Mass Vaccination: Probability of Three Sudden Deaths.
JO  - Science
JF  - Science
Y1  - 1977/03/11/
VL  - 195
IS  - 4282
M3  - Article
SP  - 934
EP  - 935
SN  - 00368075
N1  - Accession Number: 85198886; GAIL, MITCHELL 1; Affiliations: 1: Biometry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/11/1977, Vol. 195 Issue 4282, p934; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SAAVEDRA, JUAN M.
AU  - RIBAS, JORGE
AU  - SWANN, JOHN
AU  - CARPENTER, DAVID O.
T1  - Phenylethanolamine: A New Putative Neurotransmitter in Aplysia.
JO  - Science
JF  - Science
Y1  - 1977/03/11/
VL  - 195
IS  - 4282
M3  - Article
SP  - 1004
EP  - 1006
SN  - 00368075
AB  - Phenylethanolamine is present in the Aplysia nervous system in concentrations similar to that of octopamine. There are receptors that are very specific for phenylethanolamine, which on different neurons mediate sodium, chlorine, or potassium conductance increase responses. These observations indicate that phenylethanolamine may act as a neurotransmitter in Aplysia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85198918; SAAVEDRA, JUAN M. 1; RIBAS, JORGE 2; SWANN, JOHN 2; CARPENTER, DAVID O. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014; Issue Info: 3/11/1977, Vol. 195 Issue 4282, p1004; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KEIRANS, JAMES E.
T1  - Rocky Mountain Spotted Fever: Occurrence in Massachusetts.
JO  - Science
JF  - Science
Y1  - 1977/03/25/
VL  - 195
IS  - 4284
M3  - Article
SP  - 1284
EP  - 1284
SN  - 00368075
N1  - Accession Number: 85198966; KEIRANS, JAMES E. 1; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1284; Number of Pages: 1/5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Paul, William E.
AU  - Benacerraf, Baruj
T1  - Functional Specificity of Thymus- Dependent Lymphocytes.
JO  - Science
JF  - Science
Y1  - 1977/03/25/
VL  - 195
IS  - 4284
M3  - Article
SP  - 1293
EP  - 1300
SN  - 00368075
N1  - Accession Number: 85198968; Paul, William E. 1; Benacerraf, Baruj 2; Affiliations: 1: Chief of Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Professor of comparative pathology and Chairman of Department of Pathology, Harvard Medical School, Boston, Massachusetts; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1293; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FRELIER, P.
AU  - MAYHEW, I. G.
AU  - FAYER, R.
AU  - LUNDE, M. N.
T1  - Sarcocystosis: A Clinical Outbreak in Dairy Calves.
JO  - Science
JF  - Science
Y1  - 1977/03/25/
VL  - 195
IS  - 4284
M3  - Article
SP  - 1341
EP  - 1342
SN  - 00368075
AB  - Death and illness in a pen of eight yearling dairy heifers was caused by the protozoan parasite Sarcocystis. All animals had weight loss, weakness, marginal anemia, and elevated serum enzymes. Affected animals had high hemagglutinating antibody titers to Sarcocystis antigen. Affected tissues of the two animals that died demonstrated schizonts and young cysts during pathologic examination. The resident farm dog was shedding Sarcocystis sporocysts and was incriminated as the source of infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85198995; FRELIER, P. 1; MAYHEW, I. G. 2; FAYER, R. 3; LUNDE, M. N. 4; Affiliations: 1: Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853; 2: Department of Large Animal Medicine, Obstetrics and Surgery, New York State College of Veterinary Medicine; 3: Animal Parasitology Institute, Animal Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705; 4: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1341; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - O'BRIEN, STEPHEN J.
AU  - KLEINER, GAIL
AU  - OLSON, RUSSELL
AU  - SHANNON, JOHN E.
T1  - Enzyme Polymorphisms as Genetic Signatures in Human Cell Cultures.
JO  - Science
JF  - Science
Y1  - 1977/03/25/
VL  - 195
IS  - 4284
M3  - Article
SP  - 1345
EP  - 1348
SN  - 00368075
AB  - The electrophoretic resolution of seven relatively polymorphic human gene-enzyme systems expressed in tissue culture cells can be used as a sensitive genetic monitor for intraspecific cell contamination. An identical genotype at each of the same allozyme loci provides a 95 percent (or greater) confidence estimate of the identity of two cultured lines, on the basis of the allelic frequencies of the seven enzyme loci in natural populations and in populations of independently derived cultured cells. Of 27 commonly used human cell lines examined, only one of 351 pairwise comparisons proved genetically indistinguishable. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85198997; O'BRIEN, STEPHEN J. 1; KLEINER, GAIL 1; OLSON, RUSSELL 2; SHANNON, JOHN E. 3; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; 2: Flow Laboratories, Rockville, Maryland 20852; 3: American Type Culture Collection, Rockville, 20852; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1345; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GAINER, HAROLD
AU  - SARNE, YOSEF
AU  - BROWNSTEIN, MICHAEL J.
T1  - Neurophysin Biosynthesis: Conversion of a Putative Precursor During Axonal Transport.
JO  - Science
JF  - Science
Y1  - 1977/03/25/
VL  - 195
IS  - 4284
M3  - Article
SP  - 1354
EP  - 1356
SN  - 00368075
AB  - [35S] Cysteine injected adjacent to the supraoptic nucleus of the rat is rapidly incorporated into a 20,000-dalton protein that, in time, is converted to a 12,000-dalton labeled protein, neurophysin. This putative precursor of neurophysin appears to be synthesized in the supraoptic nucleus and transformed to neurophysin and related peptides during axonal transport to the neurohypophysis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199001; GAINER, HAROLD 1; SARNE, YOSEF 1; BROWNSTEIN, MICHAEL J. 2; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1354; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Solon, Jerry A.
T1  - Facing Challenges in Service-Related Research in Aging .
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1977/04//
VL  - 67
IS  - 4
M3  - Article
SP  - 328
PB  - American Public Health Association
SN  - 00900036
AB  - The article provides an overview of the study report of the authors M. W. Linn, L. Gurel and B. S. Linn about the impact of quality nursing home care on patient outcome of the aged. The study describes a typical immediate connection between research and the service world of the nursing community as research is achieved within the service setting. They have met several challenges during the investigation which include the proper application of quality care, the usage of health status outcome measures, the employment of longitudinal study designs, and the evaluation of a goal attainment model.
KW  - NURSING research
KW  - NURSING home care
KW  - OLDER people -- Home care
KW  - GERONTOLOGY
KW  - HEALTH status indicators
KW  - NURSING services
KW  - LINN, M. W.
KW  - GUREL, L.
KW  - LINN, B. S.
N1  - Accession Number: 5662514; Solon, Jerry A. 1; Affiliation:  1: Program Planning Officer, National Institute on Aging, NIH Building 31-Rm. 4B63, Bethesda, MD 20014; Source Info: Apr1977, Vol. 67 Issue 4, p328; Subject Term: NURSING research; Subject Term: NURSING home care; Subject Term: OLDER people -- Home care; Subject Term: GERONTOLOGY; Subject Term: HEALTH status indicators; Subject Term: NURSING services; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); People: LINN, M. W.; People: GUREL, L.; People: LINN, B. S.; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Adam, E.;
AU  - Decker, D. G.;
AU  - Herbst, A. L.;
AU  - Noller, K. L.;
AU  - Tilley, B. C.;
AU  - \ET/;
T1  - Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones
CT  - Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones
JO  - Cancer Research (USA)
JF  - Cancer Research (USA)
Y1  - 1977/04/01/
VL  - 37
IS  - Apr
SP  - 1249
EP  - 1251
SN  - 00085472
AD  - Professional and Public Relations Committee, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-4260; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; References: 14; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Methodology
N2  - A group has been established under the auspices of the National Institutes of Health in order to study the effects of in utero exposure to diethylstilbestrol and other synthetic estrogen compounds. The study, entitled The DESAD Project, seeks to provide answers concerning the risk to exposed offspring born after 1940 of developing cancer or other medically important conditions, including vaginal adenosis and cervical abnormalities. Each of 4 participating institutions is identifying 500 or more subjects with documented in utero exposure. Exposed daughters of different ages are being examined and followed to determine incidence and natural history of vaginal adenosis and other irregularities.
KW  - Diethylstilbestrol--toxicity-;
KW  - Toxicity--diethylstilbestrol--studies, gynecological anomalies, following in utero exposure, NIH;
KW  - Methodology--diethylstilbestrol--toxicity, studies, gynecological anomalies, following in utero exposure, NIH;
KW  - Placental transfer--diethylstilbestrol--toxicity, studies, gynecological anomalies, following in utero exposure, NIH;
KW  - National Institutes of Health--diethylstilbestrol--toxicity, studies, gynecological anomalies, following in utero exposure;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - KRAKAUER, R. S.
AU  - STROBER, W.
AU  - RIPPEON, D. L.
AU  - WALDMANN, T. A.
T1  - Prevention of Autoimmunity in Experimental Lupus Erythematosus by Soluble Immune Response Suppressor.
JO  - Science
JF  - Science
Y1  - 1977/04//4/ 1/1977
VL  - 196
IS  - 4285
M3  - Article
SP  - 56
EP  - 59
SN  - 00368075
AB  - Young NZB/W mice, treated with injections of soluble immune response suppressor (SIRS) (supernatant from mouse spleen cells exposed to concanavalin A),showed decreased immunoglobulin levels, less antibody to cell nuclei, less proteinuria, and less renal pathology as compared with NZB/W mice receiving a control preparation. Thus, SIRS administration beginning at an early age appears to be an effective therapy of the autoimmune disease in NZB/W mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199050; KRAKAUER, R. S. 1; STROBER, W. 1; RIPPEON, D. L. 1; WALDMANN, T. A. 1; Affiliations: 1: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 1/1977, Vol. 196 Issue 4285, p56; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NICHOLS, W. W.
AU  - MURPHY, D. G.
AU  - CRISTOFALO, V. J.
AU  - TOJI, L. H.
AU  - GREENE, A. E.
AU  - DWIGHT, S. A.
T1  - Characterization of a New Human Diploid Cell Strain, IMR-90.
JO  - Science
JF  - Science
Y1  - 1977/04//4/ 1/1977
VL  - 196
IS  - 4285
M3  - Article
SP  - 60
EP  - 63
SN  - 00368075
AB  - A new human diploid fibroblast-like cell line has been established from lung tissue of a female fetus. This has been frozen away in large quantity and characterized for use in research and related purposes. This is the first of a planned series of human cell lines to be established, characterized, and banked in large quantity in support of the National Institute on Aging research and general cell biology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199052; NICHOLS, W. W. 1; MURPHY, D. G. 2; CRISTOFALO, V. J. 3; TOJI, L. H. 4; GREENE, A. E. 4; DWIGHT, S. A. 4; Affiliations: 1: Institute for Medical Research, Camden, New Jersey 08103; 2: National Institute on Aging, Bethesda, Maryland 20014; 3: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 4: Institute for Medical Research; Issue Info: 4/ 1/1977, Vol. 196 Issue 4285, p60; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2013-42024-024
AN  - 2013-42024-024
AU  - Shore, Milton F.
T1  - Review of Children’s rights and the mental health professions.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1977/04//
VL  - 47
IS  - 2
SP  - 359
EP  - 360
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42024-024. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Practice; Decision Making; Mental Health Personnel. Minor Descriptor: Civil Rights; Professionalism; Prosocial Behavior. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Koocher, Gerald P. (Ed). Children’s rights and the mental health professions=259 pp. $17.95. John Wiley, New York; 1976. Page Count: 2. Issue Publication Date: Apr, 1977. 
AB  - Reviews the book, Children's Rights and the Mental Health Professions edited by Gerald P. Koocher (see record [rid]1977-13121-000[/rid]). The most notable contribution made by this book is the interweaving of research results with suggestions for changes in professional practice and policy. In this way, an empirical as well as philosophical and humanitarian basis is set for decision making and program development. The book also makes clear that there are no easy answers to the questions raised, so long as children continue to be seen as their parents' property. This book should be read over and over again and discussed in every class and meeting that deals with the professional functioning of mental health providers. Unfortunately, its high price may make the book prohibitive to many people who should read it. It seems essential that it be reissued in paperback so that students have it readily available. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health professions
KW  - professional practice
KW  - humanitarian
KW  - decision making
KW  - children rights
KW  - 1977
KW  - Clinical Practice
KW  - Decision Making
KW  - Mental Health Personnel
KW  - Civil Rights
KW  - Professionalism
KW  - Prosocial Behavior
KW  - 1977
U2  - Koocher, Gerald P. (Ed). (1976); Children’s rights and the mental health professions; 259 pp. $17.95. John Wiley, New York
DO  - 10.1037/h0098773
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - LEDER, P.
AU  - TIEMEIER, D.
AU  - ENQUIST, L.
T1  - EK2 Derivatives of Bacteriophage Lambda Useful in the Cloning of DNA from Higher Organisms: The λgtWES System.
JO  - Science
JF  - Science
Y1  - 1977/04/08/
VL  - 196
IS  - 4286
M3  - Article
SP  - 175
EP  - 177
SN  - 00368075
AB  - A derivative of bacteriophage λ has been modified and tested together with an appropriate host system to meet the criteria of EK2 biologic containment for cloning DNA from higher organisms. In this report certain of the safety features are summarized and some of the tests carried out to confirm the containment properties of the vector are described. The cloning efficiency of this system, together with available gene purification and hybrid screening technology, indicate that it can be used to clone DNA fragments carrying specific, unique mammalian genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199098; LEDER, P. 1; TIEMEIER, D. 1; ENQUIST, L. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 8/1977, Vol. 196 Issue 4286, p175; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HAMER, DEAN H.
T1  - Interbacterial Transfer of Escherichia coli- Drosophila melanogaster Recombinant Plasmids.
JO  - Science
JF  - Science
Y1  - 1977/04/08/
VL  - 196
IS  - 4286
M3  - Article
SP  - 220
EP  - 221
SN  - 00368075
AB  - Recombinants were constructed between various Escherichia coli plasmids and fragments of Drosophila melanogaster DNA. These recombinant plasmids are nonconjugative, but can be mobilized from one cell to another by conjugative sex factors. Of 47 recombinants studied, 46 were mobilized at approximately the same or slightly lower frequencies than the parental plasmids, whereas one was mobilized 1000 times less efficiently. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199118; HAMER, DEAN H. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 8/1977, Vol. 196 Issue 4286, p220; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 84008238
T1  - Real-time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary-artery disease.
AU  - Borer, Jeffrey S.
AU  - Bacharach, Stephen L.
AU  - Green, Michael V.
AU  - Kent, Kenneth M.
AU  - Epstein, Stephen E.
AU  - Johnston, Gerald S.
AU  - Mack, Bonnie
AU  - Borer, J S
AU  - Bacharach, S L
AU  - Green, M V
AU  - Kent, K M
AU  - Epstein, S E
AU  - Johnston, G S
Y1  - 1977/04/14/
N1  - Accession Number: 84008238. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Appraisal of Self-Care Agency Scale; Exercise of Self-Care Agency Scale (ESCA) (Kearney and Fleischer); Global Assessment of Functioning Scale (GAF); Defining Issues Test (DIT) (Rest); Functional Living Index: Cancer (FLIC) (Schipper et al). NLM UID: 0255562. 
KW  - Radionuclide Imaging -- Methods
KW  - Coronary Disease -- Diagnosis
KW  - Heart Function Tests -- Methods
KW  - Cineangiography -- Methods
KW  - Heart Ventricle
KW  - Coronary Angiography
KW  - Angiography
KW  - Cardiac Output
KW  - Adult
KW  - Female
KW  - Angina Pectoris -- Diagnosis
KW  - Male
KW  - Exertion
KW  - Coronary Disease -- Physiopathology
KW  - Heart Rate
KW  - Angina Pectoris -- Physiopathology
KW  - Aged
KW  - Coronary Circulation
KW  - Middle Age
KW  - Heart Ventricle -- Physiopathology
KW  - Clinical Assessment Tools
KW  - Exercise of Self-Care Agency Scale
KW  - Scales
SP  - 839
EP  - 844
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 296
IS  - 15
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - Although coronary angiography defines regions of potential ischemia in patients with coronary-artery disease, accurate assessment of the presence and functional importance of ischemia requires appraisal of regional and global left ventricular function during stress. To perform such assessment, we developed a noninvasive real-time radionuclide cineangiographic procedure permitting continuous monitoring and analysis of left ventricular function during exercise. In 11 patients with coronary disease who had normal regional and global ventricular function at rest, new regions of dysfunction developed during exercise (P less than 0.001), and in 10, global ejection fraction dropped 7 to 47 per cent. Fourteen age-matched normal subjects were studied; during exercise none had regional dysfunction, and each increased global ejection fraction (average increase, 23 +/- 3 per cent [+/-S.E.], P less than 0.001 as compared with patients with coronary disease). Radionuclide cineangiography during exercise permits accurate assessment of the presence and functional severity of ischemic heart disease.
SN  - 0028-4793
AD  - From the Cardiology Branch, National Heart, Lung, and Blood Institute, the Nuclear Medicine Department, Clinical Center, and the Division of Computer Research and Technology, National Institutes of Health (address reprint requests to Dr. Borer at the Cardiology Branch, Bldg. 10, Rm. 7B–15, National Heart, Lung, and Blood Institute, Bethesda, MD 20014).
U2  - PMID: 846493.
DO  - 10.1056/NEJM197704142961503
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - SAKURAGAWA, NORIO
AU  - SAKURAGAWA, MACHIKO
AU  - KUWABARA, TOICHIRO
AU  - PENTCHEV, PETER G.
AU  - BARRANGER, JOHN A.
AU  - BRADY, ROSCOE O.
T1  - Niemann-Pick Disease Experimental Model: Sphingomyelinase Reduction Induced by AY-9944.
JO  - Science
JF  - Science
Y1  - 1977/04/15/
VL  - 196
IS  - 4287
M3  - Article
SP  - 317
EP  - 319
SN  - 00368075
AB  - Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199164; SAKURAGAWA, NORIO 1; SAKURAGAWA, MACHIKO 2; KUWABARA, TOICHIRO 2; PENTCHEV, PETER G. 3; BARRANGER, JOHN A. 3; BRADY, ROSCOE O. 3; Affiliations: 1: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Diseases and Stroke, Bethesda, Maryland 20014; 2: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 3: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Diseases and Stroke; Issue Info: 4/15/1977, Vol. 196 Issue 4287, p317; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Schooley, R. T.;
AU  - Wagley, P. F.;
AU  - Lietman, P. S.;
T1  - Edema associated with ibuprofen therapy
CT  - Edema associated with ibuprofen therapy
JO  - J. Am. Med. Assoc.
JF  - J. Am. Med. Assoc.
Y1  - 1977/04/18/
VL  - 237
IS  - Apr 18
SP  - 1716
EP  - 1717
AD  - Reprints: Lab. of Clinical Investigation, Bldg. 10-Rm. 11S-242, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 21205
AD  - The Johns Hopkins Univ. School of Medicine, Baltimore, Maryland
N1  - Accession Number: 14-4350; Language: English; Trade Name: Motrin; Generic Name: Ibuprofen; Chemical Name: Ibuprofen--15687-27-1; References: 8; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2  - A 15 kg weight gain developed in a 71-yr-old male patient during the third week of ibuprofen (Motrin) therapy at a dosage of 400 mg 4 times daily. The edema disappeared with discontinuation of the drug regimen and did not reappear during a subsequent 6 month observation period.
KW  - Ibuprofen--adverse reactions-;
KW  - Drugs, adverse reactions--ibuprofen--weight gain, patient;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Rowe, Wallace P.
T1  - Guidelines that do the job.
JO  - Bulletin of the Atomic Scientists
JF  - Bulletin of the Atomic Scientists
Y1  - 1977/05//
VL  - 33
IS  - 5
M3  - Article
SP  - 14
EP  - 15
PB  - Bulletin of the Atomic Scientists
SN  - 00963402
N1  - Accession Number: 21639130; Rowe, Wallace P. 1; Affiliation:  1: Chief, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, md; Source Info: May1977, Vol. 33 Issue 5, p14; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Morris, D.;
AU  - Aisner, J.;
AU  - Wiernik, P. H.;
T1  - Horizontal pigmented banding of the nails in association with adriamycin chemotherapy
CT  - Horizontal pigmented banding of the nails in association with adriamycin chemotherapy
JO  - Cancer Treat. Rep.
JF  - Cancer Treat. Rep.
Y1  - 1977/05/01/
VL  - 61
IS  - May-Jun
SP  - 499
EP  - 501
AD  - Dept. of Surgery, and Baltimore Cancer Research Center, Div. of Cancer Treatment, National Cancer Institute, Univ. of Maryland Hospital, 22 S. Greene St., Baltimore, Maryland 21202
N1  - Accession Number: 14-5506; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 18; Publication Type: Letters; Journal Coden: CCYPBY; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Walter Howard
N2  - Horizontal pigmented banding of nails was reported in 7 black patients receiving combination chemotherapy including doxorubicin. These bands usually appeared 6-8 weeks after initiation of chemotherapy, and began to disappear 6-8 weeks after discontinuation of doxorubicin. White patients receiving similar drug combinations did not demonstrate this effect. A possible mechanism of action is proposed.
KW  - Doxorubicin--adverse reactions-;
KW  - Drugs, adverse reactions--doxorubicin--pigmentation, nail, banding, mechanism of action, black patients;
KW  - Mechanism of action--doxorubicin--pigmentation, nail, banding, black patients;
KW  - Pharmacogenetics--doxorubicin--pigmentation, nail, banding, black patients;
KW  - Antineoplastic agents--doxorubicin--pigmentation, nail, banding, black patients;
KW  - Race--doxorubicin--pigmentation, nail, banding, black patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Shapiro, Marvin
T1  - The Choice of Reference Points in Best-Match File Searching.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1977/05//
VL  - 20
IS  - 5
M3  - Article
SP  - 339
EP  - 343
SN  - 00010782
AB  - Improvements to the exhaustive search method of best-match file searching have previously been achieved by doing a preprocessing step involving the calculation of distances from a reference point. This paper discusses the proper choice of reference points and extends the previous algorithm to use more than one reference point. It is shown that reference points should be located outside of data clusters. The results of computer simulations are presented which show that large improvements can be achieved by the proper choice and location of multiple reference points. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALGORITHMS
KW  - COMPUTER simulation
KW  - ELECTROMECHANICAL analogies
KW  - MATHEMATICAL models
KW  - SIMULATION methods & models
KW  - ARITHMETIC
KW  - MODELS & modelmaking
KW  - ENGINEERING models
KW  - MECHANICS (Physics)
KW  - best match
KW  - file searching
KW  - matching
KW  - nearest-neighbor classification
N1  - Accession Number: 5495656; Shapiro, Marvin 1; Affiliation:  1: National Institutes of Health.; Source Info: May77, Vol. 20 Issue 5, p339; Subject Term: ALGORITHMS; Subject Term: COMPUTER simulation; Subject Term: ELECTROMECHANICAL analogies; Subject Term: MATHEMATICAL models; Subject Term: SIMULATION methods & models; Subject Term: ARITHMETIC; Subject Term: MODELS & modelmaking; Subject Term: ENGINEERING models; Subject Term: MECHANICS (Physics); Author-Supplied Keyword: best match; Author-Supplied Keyword: file searching; Author-Supplied Keyword: matching; Author-Supplied Keyword: nearest-neighbor classification; Number of Pages: 5p; Illustrations: 5 Diagrams; Document Type: Article
L3  - 10.1145/359581.359599
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ward, G.;
T1  - How the pharmacist can help in long-term maintenance of antihypertensive therapy
CT  - How the pharmacist can help in long-term maintenance of antihypertensive therapy
JO  - J. Am. Pharm. Assoc.
JF  - J. Am. Pharm. Assoc.
Y1  - 1977/05/01/
VL  - NS 17
IS  - May
SP  - 301
EP  - 302
AD  - National High Blood Pressure Education Program, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-4912; Language: English; References: 7; Journal Coden: JPHAA3; Section Heading: Pharmaceutical Education; Pharmacy Practice; Abstract Author: James A. Starner
N2  - Various ways in which the pharmacist can help to educate and make patients aware of the importance of therapy for reducing hypertension are presented.
KW  - Pharmacists--role--education, hypertensive patients;
KW  - Education--patients--hypertension, pharmacist's role;
KW  - Patients--education--hypertension, pharmacist's role;
KW  - Hypertension--education--patients, pharmacist's role;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Mackerer, Carl R.
AU  - Saunders, Robert N.
AU  - Haettinger, Janet R.
AU  - Mehlman, Myron A.
T1  - Assessment of diabetogenic drug activity in the rat: 5,5‐Diphenyl‐2‐thiohydantoin.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1977/05//
VL  - 2
IS  - 5
M3  - Article
SP  - 1041
EP  - 1051
SN  - 00984108
AB  - The diabetogenic activity of 5,5‐diphenyl‐2‐thiohydantoin (DPTH) via oral administration was assessed in both normal and streptozotocin diabetic rats. Rats were fed powdered chow diet with and without 0.1% (w/w) DPTH. Food consumption and body weight were recorded every other day; whole blood glucose concentrations were determined at the start of the study and at the midpoint. At sacrifice, liver and pancreas were excised and blood samples were collected. Protein and lipid levels were determined in liver; insulin in pancreas; and glucose, insulin, and lipid in blood. DPTH treatment caused decreased food consumption and body weight gain. The drug dose, calculated from the food consumption data, was 76.5 mg/kg/day for the normal rats and 107 mg/kg/day for the diabetic rats. DPTH increased liver weight and liver lipid content in both normal and diabetic rats, and markedly lowered serum triglyceride concentration in normal rats but not in diabetic rats. Serum fatty acid concentration was not altered by DPTH. DPTH produced a significant elevation of blood glucose concentration of the diabetic rats that was not, however, correlated with altered pancreatic insulin concentration. In vitro, DPTH infusion inhibited insulin secretion by the perfused pancreas. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75456846; Mackerer, Carl R. 1 Saunders, Robert N. 2 Haettinger, Janet R. 2 Mehlman, Myron A. 3; Affiliation:  1: Pharmacodynamics Section, Department of Biological Research, Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680  2: Department of Biological Research, Searle Laboratories, Chicago, Illinois  3: National Institutes of Health, Bethesda, Maryland; Source Info: May1977, Vol. 2 Issue 5, p1041; Number of Pages: 11p; Document Type: Article
L3  - 10.1080/15287397709529502
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HAYES, RONALD
AU  - PRICE, DONALD D.
AU  - DUBNER, RONALD
T1  - Naloxone Antagonism as Evidence for Narcotic Mechanisms.
JO  - Science
JF  - Science
Y1  - 1977/05/06/
VL  - 196
IS  - 4290
M3  - Article
SP  - 600
EP  - 600
SN  - 00368075
N1  - Accession Number: 85199237; HAYES, RONALD 1; PRICE, DONALD D. 1; DUBNER, RONALD 1; Affiliations: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/ 6/1977, Vol. 196 Issue 4290, p600; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GILLESPIE, DAVID
T1  - Newly Evolved Repeated DNA Sequences in Primates.
JO  - Science
JF  - Science
Y1  - 1977/05/20/
VL  - 196
IS  - 4292
M3  - Article
SP  - 889
EP  - 891
SN  - 00368075
AB  - Repeated DNA sequences in primates having identical or nearly identical members and exhibiting unusual phylogenetic specificity were analyzed. They appeared in repeated DNA sequences in each group ofprimates, probably within the last 10 to 15 million years, and are conserved to the same extent as unique DNA sequences. The finding allows a new approach to the construction of evolutionary trees. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436315; GILLESPIE, DAVID 1; Affiliations: 1: Section on Nucleic Acid Hybridization, Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 5/20/1977, Vol. 196 Issue 4292, p889; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LAKE, C. RAYMOND
AU  - ZIEGLER, MICHAEL G.
T1  - Lesch-Nyhan Syndrome: Low Dopamine-β-Hydroxylase-Activity and Diminished Sympathetic Response to Stress and Posture.
JO  - Science
JF  - Science
Y1  - 1977/05/20/
VL  - 196
IS  - 4292
M3  - Article
SP  - 905
EP  - 906
SN  - 00368075
AB  - Patients with Lesch-Nyhan syndrome with virtually no hypoxanthine phosphoribosyltransferase activity demonstrate significantly low plasma activity of dopamineβ-hydroxylase but normal basal levels of norepinephrine. Under conditions of emotional or postural stress the plasma concentrations ofnorepinephrine in Lesch-Nyhan patients increased less than in a normal population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436325; LAKE, C. RAYMOND 1; ZIEGLER, MICHAEL G. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Pharmacology, University of Texas Medical Center, Galveston 77550; Issue Info: 5/20/1977, Vol. 196 Issue 4292, p905; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHRISTIAN, C. N.
AU  - NELSON, P. G.
AU  - PEACOCK, J.
AU  - NIRENBERG, M.
T1  - Synapse Formation Between Two Clonal Cell Lines.
JO  - Science
JF  - Science
Y1  - 1977/05/27/
VL  - 196
IS  - 4293
M3  - Article
SP  - 995
EP  - 998
SN  - 00368075
AB  - Clonal neuroblastoma x glioma hybrid cellsfrequentlyformed synapses with clonal mouse striated muscle cells. Clonal myotubes were similar to cultured mouse embryo myotubes with respect to acetylcholine sensitivity and other membrane properties examined. However, acetylcholine sensitivity measurements indicate that acetylcholine receptors of clonal myotubes are distributed more uniformly over the cell surface than the receptors of cultured mouse embryo myotubes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436350; CHRISTIAN, C. N. 1; NELSON, P. G. 1; PEACOCK, J. 2; NIRENBERG, M. 3; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Neurology, Stanford Medical School, Stanford, California; 3: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health; Issue Info: 5/27/1977, Vol. 196 Issue 4293, p995; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KAPOOR, C. L.
AU  - KRISHNA, G.
T1  - Hormone-Induced Cyclic Guanosine Monophosphate Secretion from Guinea Pig Pancreatic Lobules.
JO  - Science
JF  - Science
Y1  - 1977/05/27/
VL  - 196
IS  - 4293
M3  - Article
SP  - 1003
EP  - 1005
SN  - 00368075
AB  - Carbamylcholine (30 μM) increased the concentration of guanosine 3',5'-monophosphate (cyclic GMP) in guinea pig pancreatic lobules about eight- to tenfold over the basal concentration in 30 seconds with a concomitant increase in the rate of amylase secretion. The concentration of cyclic GMP rapidly declined to a plateau value of about 16 percent of the peak level in 10 minutes. Cellular cyclic GMP decreased, mostly because the nucleotide was secreted into the medium; cellular adenosine 3',5'-monophosphate (cyclic AMP), however, did not change, nor was this nucleotide secreted into the medium. An immunocytochemical technique showed that cyclic GMP was distributed in the apical plasmalemma membrane and lumen of the pancreas. Carbamylcholine increased the cyclic GMP fluorescence in the apical plasmalemma membrane within 30 seconds, and in zymogen granules and the plasma membrane in the apical part of acinar cells in 10 minutes. The islets of Langerhans did not show any change in cyclic GMP. Fluorescence of cyclic AMP in pancreatic lobules was not altered by carbamylcholine and was localized along the apical portion of plasmalemma and cytoplasm. Cyclic GMP may thus participate either in the process of exocytosis or in the activation of enzymes secreted from the pancreas. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436363; KAPOOR, C. L. 1; KRISHNA, G. 1; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 5/27/1977, Vol. 196 Issue 4293, p1003; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, R. C.;
AU  - Lippman, M.;
AU  - De Vita, V. T.;
AU  - Bull, J.;
AU  - Tormey, D.;
T1  - Perspectives in the treatment of breast cancer: 1976
CT  - Perspectives in the treatment of breast cancer: 1976
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1977/06/01/
VL  - 86
IS  - Jun
SP  - 784
EP  - 798
SN  - 00034819
AD  - Medicine Branch, National Cancer Institute, Bldg. 10, Rm. 12N-236, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-6478; Language: English; References: 75; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Charles C. Depew
N2  - Surgical and chemotherapeutic advances in the treatment of breast cancer are reviewed. Surgery, radiotherapy, and hormonal therapy for early breast cancer; single agent versus combination chemotherapy in advanced breast cancer; and adjuvant chemotherapy after breast cancer surgery are examined. A discussion is presented in which the results of a prospective randomized trial indicate that the response rate to cyclophosphamide, doxorubicin, and fluorouracil is significantly better than to cyclophosphamide, methotrexate, and fluorouracil. Tables are presented showing the percent response to the different chemotherapeutic agents. Side effects and adverse reactions are also mentioned. The major conclusion is that at this time, combination chemotherapy is superior to single agent chemotherapy in treatment of advanced breast cancer. Examples of ongoing controlled trials after radical mastectomy with prolonged adjuvant therapy in primary breast cancer with positive axillary nodes are presented.
KW  - Antineoplastic agents--combined therapy--cancer, breast, review;
KW  - Combined therapy--antineoplastic agents--cancer, breast, review;
KW  - Rational therapy--antineoplastic agents--cancer, breast, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rozencweig, M.;
AU  - Von Hoff, D. D.;
AU  - Slavik, M.;
AU  - Muggia, F. M.;
T1  - \LC/cis\UC/-Diamminedichloroplatinum II. New anticancer drug
CT  - \LC/cis\UC/-Diamminedichloroplatinum II. New anticancer drug
JO  - Annals of Internal Medicine (USA)
JF  - Annals of Internal Medicine (USA)
Y1  - 1977/06/01/
VL  - 86
IS  - Jun
SP  - 803
EP  - 812
SN  - 00034819
AD  - Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bldg. 37, Rm. 6E12, Bethesda, Maryland 20014
N1  - Accession Number: 14-6381; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cis-diamminedichloroplatinum; References: 141; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs; PharmacologyDrug Metabolism and Body Distribution; Abstract Author: Charles C. Depew
N2  - A review of the investigational antitumor agent, cis-diamminedichloroplatinum (I), is presented. I is an inorganic complex formed by a central atom of platinum surrounded by chlorine and ammonia atoms. The mechanism of action remains inconclusive at this time. Pharmacokinetic studies in man indicate an initial half-life of 25-49 min and the secondary half-life of 58-73 hr. In clinical trials, I was administered by either rapid IV infusion or by slow IV drip. A table of the different dosing schedules is presented. The 2 most commonly used schedules are: 50-75 mg/sq m body surface area once every 3 weeks and; 15-20 mg/sq m body surface area daily for 5 consecutive days repeated every 3 or 4 weeks. The antineoplastic activity against testicular, ovarian, bladder, head and neck, and childhood carcinomas of I alone and in combination with other agents is discussed. The major toxicities are gastrointestinal and renal impairment. A reduction of renal impairment may be achieved by mannitol induced diuresis with or without furosemide. Other toxicities include ototoxicity, myelosuppression, and anaphylactoid reactions. The dosage ranges at which these reactions occur are presented. The role of I in the treatment of cancer remains inconclusive at this time.
KW  - cis-Diamminedichloroplatinum--cancer-;
KW  - Antineoplastic agents--cis-diamminedichloroplatinum--cancer, therapy, half-life, dosage schedules, and side effects, review;
KW  - Half-life--cis-diamminedichloroplatinum--cancer, therapy, dosage schedules, and side effects, review;
KW  - Dosage schedules--cis-diamminedichloroplatinum--cancer, therapy, half-life, and side effects, review;
KW  - Toxicity--cis-diamminedichloroplatinum--side effects, half-life, dosage schedules, and cancer therapy, review;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Barrett, David E.
AU  - Yarrow, Marian Radke
T1  - Prosocial Behavior, Social Inferential Ability, and Assertiveness in Children.
JO  - Child Development
JF  - Child Development
Y1  - 1977/06//
VL  - 48
IS  - 2
M3  - Article
SP  - 475
EP  - 481
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 11233394; Barrett, David E. 1 Yarrow, Marian Radke 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Jun1977, Vol. 48 Issue 2, p475; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1467-8624.ep11233394
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Chapin, Ned
AU  - Denning, Peter J.
AU  - Rose, Lois A.
AU  - Cichelli, Martha J.
AU  - Clemons, Eric K.
AU  - Gerretsen, Rob
AU  - Van Gelder, Allen
AU  - Lyons, W. W.
AU  - Shapiro, Marvin
AU  - Maisel, Herbert
AU  - Karp, Richard A.
AU  - Borko, Harold
AU  - Hartford, Donald L.
AU  - Irwin, Alan E.
AU  - Heffner, Horace
AU  - Rockwell, Robert
AU  - Fern, Jr., C. J.
AU  - Baieman, Barry L.
AU  - Durham, Paul
AU  - Weicker, Reinhold
T1  - acm forum.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1977/06//
VL  - 20
IS  - 6
M3  - Letter
SP  - 445
EP  - 452
SN  - 00010782
AB  - Presents several letters to the editor referencing the topics and the articles published in the previous issues of the journal "Communications of the ACM." Comments on the article "Structured Programming in Cobol," which focused on the benefits of using structured programming; Information on different aspects of structured programming; Remarks on the publications from (Association for Computing Machinery).
KW  - LETTERS to the editor
KW  - STRUCTURED programming
KW  - ELECTRONIC data processing -- Structured techniques
KW  - COBOL (Computer program language)
KW  - PUBLICATIONS
KW  - ASSOCIATION for Computing Machinery
N1  - Accession Number: 17845614; Chapin, Ned 1 Denning, Peter J. 2 Rose, Lois A. Cichelli, Martha J. 3 Clemons, Eric K. 4 Gerretsen, Rob 4 Van Gelder, Allen Lyons, W. W. Shapiro, Marvin 5 Maisel, Herbert Karp, Richard A. 6 Borko, Harold 7 Hartford, Donald L. 8 Irwin, Alan E. Heffner, Horace Rockwell, Robert Fern, Jr., C. J. Baieman, Barry L. Durham, Paul Weicker, Reinhold 9; Affiliation:  1: InfoSci Inc., Box 7117, Menlo Park, CA 94025.  2: Computer Sciences Department, Purdue University, West Lafayette, IN 47907.  3: Software Consulting Services, Allentown, PA 18103.  4: Department of Decision Sciences, Wharton School University of Pennsylvania, Philadelphia, PA 19174.  5: Computer Division, National Institutes of Health, Bethesda, MD 20014.  6: Artificial Intelligence Laboratory, Stanford University Stanford, CA 94305.  7: University of California, Los Angeles, CA 90024.  8: Pepperdine University, Los Angeles, CA 90044.  9: Suenens AG, Erlangen, West Germany.; Source Info: Jun77, Vol. 20 Issue 6, p445; Subject Term: LETTERS to the editor; Subject Term: STRUCTURED programming; Subject Term: ELECTRONIC data processing -- Structured techniques; Subject Term: COBOL (Computer program language); Subject Term: PUBLICATIONS; Company/Entity: ASSOCIATION for Computing Machinery; Number of Pages: 8p; Document Type: Letter
L3  - 10.1145/359605.359635
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Schuster, Marvin M.
T1  - Gastrointestinal tract dysfunctions respond to biofeedback.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1977/06//
VL  - 32
IS  - 6
M3  - Interview
SP  - 32
EP  - 41
SN  - 0016867X
N1  - Accession Number: 17321256; Schuster, Marvin M. 1,2,3; Source Information: Jun1977, Vol. 32 Issue 6, p32; Number of Pages: 3p; Document Type: Interview; Full Text Word Count: 1157
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Balow, J.E.
AU  - Parrillo, J.E.
AU  - Fauci, A.S.
T1  - Characterization of the direct effects of cyclophosphamide on cell-mediated immunological responses.
JO  - Immunology
JF  - Immunology
Y1  - 1977/06//
VL  - 32
IS  - 6
M3  - Article
SP  - 899
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Examines the immunosuppressive effects of cyclophosphamide in normal guinea pig mononuclear cells.  Induced changes in leucocyte functions; Depression of migration inhibitory factor production; Depression of certain cytotoxicity reactions.
KW  - IMMUNOSUPPRESSION
KW  - IMMUNOSUPPRESSIVE agents
KW  - GUINEA pigs as laboratory animals
N1  - Accession Number: 11177608; Balow, J.E. 1 Parrillo, J.E. 1 Fauci, A.S. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, U.S.A.; Source Info: Jun77, Vol. 32 Issue 6, p899; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: GUINEA pigs as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - van Kammen, Daniel P.
AU  - Money, John
T1  - EROTIC IMAGERY AND SELF-CASTRATION IN TRANSVESTISM/TRANSSEXUALISM: A CASE REPORT.
JO  - Journal of Homosexuality
JF  - Journal of Homosexuality
Y1  - 1977///Summer77
VL  - 2
IS  - 4
M3  - Article
SP  - 359
EP  - 366
SN  - 00918369
AB  - After nearly 30 years of marriage, a 51-year-old man castrated himself in order to fulfill a long-standing fantasy of being a girl. There was a prior history of cross-dressing since childhood, and of reversed erotic role imagery during coitus. There was no history of schizophrenia or psychotic depression. Pair bonding with the wife was very strong. It led the patient to elect low-dose maintenance on androgen so as to permit some degree of continued marital sex. Otherwise the patient would have preferred estrogenization and, perhaps, eventual sex reassignment. The rehabilitative program as a transvestite man has continued for 3 years. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Homosexuality is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EROTICA
KW  - CASTRATION
KW  - PSYCHOSEXUAL disorders
KW  - SEXUAL disorders
KW  - GENDER dysphoria
KW  - TRANSVESTISM
KW  - TRANSSEXUALISM
KW  - TRANSSEXUALS
N1  - Accession Number: 11783398; van Kammen, Daniel P. 1 Money, John 2; Affiliation:  1: Section on Neuropsychopharmacology, Adult Psychiatry Branch, National Institute of Mental Health  2: Departments of Psychiatry, Behavioral Sciences, and Pediatrics, Johns Hopkins University and Hospital; Source Info: Summer77, Vol. 2 Issue 4, p359; Subject Term: EROTICA; Subject Term: CASTRATION; Subject Term: PSYCHOSEXUAL disorders; Subject Term: SEXUAL disorders; Subject Term: GENDER dysphoria; Subject Term: TRANSVESTISM; Subject Term: TRANSSEXUALISM; Subject Term: TRANSSEXUALS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Beisler, J. A.;
AU  - Peng, G. W.;
AU  - Driscoll, J. S.;
T1  - Potential antitumor agents: procarbazine analogs and other methylhydrazine derivatives
CT  - Potential antitumor agents: procarbazine analogs and other methylhydrazine derivatives
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1977/06/01/
VL  - 66
IS  - Jun
SP  - 849
EP  - 852
SN  - 00223549
AD  - Drug Design and Chemistry Section, Lab. of Medicinal Chemistry and Biology, Drug Research and Development Program, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1  - Accession Number: 14-5097; Language: English; Chemical Name: Procarbazine--671-16-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents procarbazine; References: 20; Journal Coden: JPMSAE; Section Heading: Pharmacology; Pharmaceutical Chemistry
N2  - With the objective of developing new antitumor agents, 2 groups of hydrazine compounds, having structural features in common with the antitumor agents procarbazine and 1-acetyl-2-picolinoylhydrazine, were synthesized. The L-1210 leukemia system was used to evaluate compounds of both groups. The aliphatic procarbazines also were screened for antitumor activity as bis(benzyloxycarbonyl) derivatives and as derivatives having a phthalazine nucleus. No L-1210 antitumor activity was exhibited by these compounds.
KW  - Procarbazine--derivatives-;
KW  - Hydrazines--synthesis--lack, antitumor effects, in vitro;
KW  - Antineoplastic agents--hydrazines--synthesis, and lack, antitumor effects, in vitro;
KW  - Antineoplastic agents--procarbazine--derivatives, aliphatic, synthesis, and lack, antitumor effects, in vitro;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Ellenberg, Jonas H.
T1  - The Joint Distribution of the Standardized Row Sums of Squares from a Balanced Two-Way Layout.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1977/06//
VL  - 72
IS  - 358
M3  - Article
SP  - 407
SN  - 01621459
AB  - A balanced two-way layout with no interaction is considered with the observations y[sub ij] being arranged in r rows and c columns (I = 1, ..., r, j = 1, ..., c). The error sum of squares for each row is defined as S[sub I] = SIGMA[sup c, sub j =1] (y[sub ij] - y[sub I.] - y[sub .j] + y[sub ..])[sup 2], and the total error sum of squares is defined as S = SIGMA[sup r, sub I=1] S[sub I]. The joint distribution of S[sub 1], ..., S[sub k] (k less than or equal to r) and the joint distribution of S[sub 1]/S, ..., S[sub k]/S (k < r) are derived. The distributional results are of the form conjectured by N.L. Johnson (1962). Finally, a procedure is considered for testing equality of the variances in the different rows which assumes the column variances are equal. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - ANALYSIS of variance
KW  - VARIANCES
KW  - PROBABILITY theory
KW  - STATISTICS
KW  - EQUALITY
KW  - Bonferroni inequality.
KW  - Heterogeneity ut two-way layout
KW  - Standardized row sums of squares
N1  - Accession Number: 4608461; Ellenberg, Jonas H. 1; Affiliations: 1: Acting Head, Section on Mathematical Statistics, Office of Biometry, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20014.; Issue Info: Jun77, Vol. 72 Issue 358, p407; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ANALYSIS of variance; Thesaurus Term: VARIANCES; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICS; Subject Term: EQUALITY; Author-Supplied Keyword: Bonferroni inequality.; Author-Supplied Keyword: Heterogeneity ut two-way layout; Author-Supplied Keyword: Standardized row sums of squares; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Anderson, Dallas W.
T1  - Probability Sampling of Hospitals and Patients (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1977/06//
VL  - 72
IS  - 358
M3  - Book Review
SP  - 483
SN  - 01621459
AB  - Reviews the book "Probability Sampling of Hospitals and Patients," 2nd ed., by Irene Hess, Donald C. Riedel and Thomas B. Fitzpatrick.
KW  - PROBABILITY theory
KW  - NONFICTION
KW  - HESS, Irene
KW  - RIEDEL, Donald
KW  - RIEDEL, Donald C.
KW  - FITZPATRICK, Thomas
KW  - FITZPATRICK, Thomas B.
KW  - PROBABILITY Sampling of Hospitals & Patients (Book)
N1  - Accession Number: 4608738; Anderson, Dallas W. 1; Affiliations: 1: National Institutes of Health.; Issue Info: Jun77, Vol. 72 Issue 358, p483; Thesaurus Term: PROBABILITY theory; Subject Term: NONFICTION; Reviews & Products: PROBABILITY Sampling of Hospitals & Patients (Book); People: HESS, Irene; People: RIEDEL, Donald; People: RIEDEL, Donald C.; People: FITZPATRICK, Thomas; People: FITZPATRICK, Thomas B.; Number of Pages: 1/2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - YANG, SHEN K.
AU  - MCCOURT, DAVID W.
AU  - LEUTZ, JANET C.
AU  - GELBOIN, HARRY V.
T1  - Benzo[a]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates.
JO  - Science
JF  - Science
Y1  - 1977/06/10/
VL  - 196
IS  - 4295
M3  - Article
SP  - 1199
EP  - 1200
SN  - 00368075
AB  - Studies of the mechanism of benzo[a]pyrene metabolism to reactive diol epoxides and of their disposition indicate that the metabolic intermediates of the activation pathways, 7,8-epoxide and trans-7,8-diol, as well as the two stereoisomeric diol epoxides are all optically active. Benzo[a]pyrene is converted to optically active 9, 10-epoxides of(-)trans-7,8-diol by three enzymatic steps: (i) stereospecific oxygenation at the 7,8 double bond of benzo[a]pyrene by the mixed-function oxidases to essentially a single enantiomer of 7,8-epoxide, (ii) hydration of the 7,8-epoxide by epoxide hydratase to an optically pure (-)trans-7,8-diol, and (iii) stereoselective oxygenation by the mixed-function oxidases at the 9,10 double bond of the (-) trans-7,8-diol to optically active r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene and optically active r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo-[a]pyrene in a ratio of approximately 10 to 1. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460575; YANG, SHEN K. 1; MCCOURT, DAVID W. 1; LEUTZ, JANET C. 1; GELBOIN, HARRY V. 1; Affiliations: 1: Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/10/1977, Vol. 196 Issue 4295, p1199; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BENZ, JR., EDWARD
AU  - TURNER, PATRICIA
AU  - BARKER, JANE
AU  - NIENHUIS, ARTHUR
T1  - Stability of the Individual Globin Genes During Erythroid Differentiation.
JO  - Science
JF  - Science
Y1  - 1977/06/10/
VL  - 196
IS  - 4295
M3  - Article
SP  - 1213
EP  - 1214
SN  - 00368075
AB  - The genes for sheep βA, βC, and γ globin were all present in DNA from erythroid cells which synthesized only βC globin. Similarly, selective excision of non-expressed genes was shown not to occur during human erythroid differentiation. In contrast, evolutionary deletion of the βc gene accounts for the inability of many sheep to make this globin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460554; BENZ, JR., EDWARD 1; TURNER, PATRICIA 1; BARKER, JANE 1; NIENHUIS, ARTHUR 1; Affiliations: 1: Section on Clinical Hematology, Molecular Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Issue Info: 6/10/1977, Vol. 196 Issue 4295, p1213; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carman, J. S.;
AU  - Wyatt, R. J.;
T1  - Reduction of serum prolactin after subcutaneous salmon calcitonin
CT  - Reduction of serum prolactin after subcutaneous salmon calcitonin
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1977/06/11/
VL  - 1
IS  - Jun 11
SP  - 1267
EP  - 1268
SN  - 00237507
AD  - Lab. of Clinical Psychopharmacology, National Institute of Mental Health, Washington, D.C. 20032
N1  - Accession Number: 14-6200; Language: English; Chemical Name: Calcitonin--9007-12-9; References: 7; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2  - Injections of synthetic salmon calcitonin (I) resulted in a substantial decrease in serum prolactin in 9 psychotic inpatients. I and placebo injections were supplied in sterile vials of 200 MRC units/ml. Each patient was given at least one active and one placebo injection of 0.70 ml SC on the volar forearm at 7 p.m. each evening. From venous blood drawn at 7 a.m. on the following morning, serum prolactin was determined by radioimmunoassay.
KW  - Calcitonin--salmon-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MINNERS, HOWARD A.
T1  - Tropical Medicine-New Vigor.
JO  - Science
JF  - Science
Y1  - 1977/06/17/
VL  - 196
IS  - 4296
M3  - Article
SP  - 1275
EP  - 1275
SN  - 00368075
N1  - Accession Number: 85218442; MINNERS, HOWARD A. 1; Affiliations: 1: Associate Director for International Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20014; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1275; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SLISKI, A. H.
AU  - ESSEX, M.
AU  - MEYER, C.
AU  - TODARO, G.
T1  - Feline Oncornavirus-Associated Cell Membrane Antigen: Expression in Transformed Nonproducer Mink Cells.
JO  - Science
JF  - Science
Y1  - 1977/06/17/
VL  - 196
IS  - 4296
M3  - Article
SP  - 1336
EP  - 1339
SN  - 00368075
AB  - The feline oncornavirus-associated cell membrane (tntigen (FOCMA) is a target for naturally occurring immunity that protec ts the cat against development of fibrosarcoma and leukemia. Feline sarcoma virus-transformed "nonproducer" mink cells express high levels of FOCMA, but not of the major viral structural proteins. Transformation of the same cells by murihe satrcoma virus, or infection with feline leukemia virus, which is nontransforming for epithelial or fibr-oblastic cells, did not induce FOCMA. Thus, FOCMA expression in mink lung cells is specifically associated with transformation by feline sarcoma virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218465; SLISKI, A. H. 1; ESSEX, M. 1; MEYER, C. 2; TODARO, G. 2; Affiliations: 1: Department of Microbiology, Harvard University School of Public Health, Boston, Massachusetts 02115; 2: Laboraitory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1336; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PIATIGORSKY, JORAM
AU  - SHINOHARA, TOSHIMICHI
T1  - Lens Cataract Formation and Reversible Alteration in Crystallin Synthesis in Cultured Lenses.
JO  - Science
JF  - Science
Y1  - 1977/06/17/
VL  - 196
IS  - 4296
M3  - Article
SP  - 1345
EP  - 1347
SN  - 00368075
AB  - Embryonic chick lenses developed cortical cataracts and altered their pattern of δ-crystallin synthesis within 3 hours, ifcultured without their vitreous body or traumatized with their vitreous body attached. δ-Crystallin reverted to the normal pattern by 24 hours in the cataractous lenses. Thus, biochemical differences that are only observable during the initial stages of cataractogenesis can exist between opaque and normal lenses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218469; PIATIGORSKY, JORAM 1; SHINOHARA, TOSHIMICHI 1; Affiliations: 1: Section on Cellular Differentiation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1345; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Dienstag, Jules L.
AU  - Alaama, Abdul
AU  - Mosley, James W.
AU  - Redeker, Allan G.
AU  - Purcell, Robert H.
T1  - Etiology of Sporadic Hepatitis B Surface Antigen-Negative Hepatitis.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/07//
VL  - 87
IS  - 1
M3  - Article
SP  - 1
EP  - 6
SN  - 00034819
AB  - We studied serologically 45 adults who had sporadic acute viral hepatitis that was hepatitis B surface antigen (HBsAg) negative. Two cases were due to hepatitis B virus, as demonstrated by the appearance of antibody to hepatitis B core antigen. in three other patients, the serologic pattern was Inconclusive. 0140 non-B cases, 20 were type A hepatitis and 20 were non-A, non-B hepatitis. Clinically, type A and non-A, non-B hepatitis were indistinguishable; one case of fulminent disease occurred in each group. The type A cases were more frequent in young adults; non-A, non-B disease predominated in women 35 years or older. Epidemiologic backgrounds were generally similar, including illicit self-injection; but four transfusion-associated cases were limited to the non-A, non-B group. We conclude that relatively few HBsAg-negative cases are due to hepatitis B virus, and that hepatitis A virus and non-A, non-B viruses are both important in acute non-B disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS
KW  - LIVER diseases
KW  - COMMUNICABLE diseases
KW  - ANTIGENS
KW  - DISEASES -- Causes & theories of causation
KW  - HEMATOLOGY
N1  - Accession Number: 14147553; Dienstag, Jules L. 1,2; Alaama, Abdul 1,2; Mosley, James W. 1,2; Redeker, Allan G. 1,2; Purcell, Robert H. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p1; Subject: HEPATITIS; Subject: LIVER diseases; Subject: COMMUNICABLE diseases; Subject: ANTIGENS; Subject: DISEASES -- Causes & theories of causation; Subject: HEMATOLOGY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Szmuness, Wolf
AU  - Dienstag, Jules L.
AU  - Purcell, Robert H.
AU  - Prince, Alfred M.
AU  - Stevens, Cladd E.
AU  - Levine, Richard W.
T1  - Hepatitis Type A and Hemodialysis.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/07//
VL  - 87
IS  - 1
M3  - Article
SP  - 8
EP  - 12
SN  - 00034819
AB  - Four hundred sixty patients and staff from 15 U.S. dialysis centers were surveyed by the immune adherence hemagglutination technique for antibody to hepatitis A antigen (anti-HA) The age-standardized and-HA prevalence was 42.9% in patients and 42.1% In staff. These rates are almost Identical to those of socioeconomically comparable urban volunteer blood donors never exposed to dialysis settings. There was no correlation between anti-HA prevalences and duration of dialysis treatment or employment. Among 100 patients and staff followed for 1 year 92% to 94% did not change their anti-HA status. The prevalence, of anti-HA was identical In subjects with past histories of multiple blood transfusions or accidental Inoculations with blood-contaminated instruments and in those without such histories. We conclude that hepatitis A virus rarely if ever spreads by parenteral mechanisms that there is no epidemiologic evidence confirming the existence of chronic hepatitis A viremic carrier states, and that hemodlalysis does not play a significant role in the spread of type A hepatitis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS
KW  - COMMUNICABLE diseases
KW  - LIVER diseases
KW  - ANTIGENS
KW  - DIALYSIS (Chemistry)
KW  - HEMAGGLUTINATION tests
KW  - HEMAGGLUTININ
N1  - Accession Number: 14147567; Szmuness, Wolf 1,2; Dienstag, Jules L. 1,2; Purcell, Robert H. 1,2; Prince, Alfred M. 1,2; Stevens, Cladd E. 1,2; Levine, Richard W. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p8; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: ANTIGENS; Subject: DIALYSIS (Chemistry); Subject: HEMAGGLUTINATION tests; Subject: HEMAGGLUTININ; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Hoofnagle, Jay H.
AU  - Gerety, Robert J.
AU  - Tabor, Edward
AU  - Feinstotne, Stephen M.
AU  - Barker, Lewellys F.
AU  - Purcell, Robert H.
T1  - Transmission of Non-A, Non-B Hepatitis.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/07//
VL  - 87
IS  - 1
M3  - Article
SP  - 14
EP  - 20
SN  - 00034819
AB  - In studies conducted In the early 1950s, an from six asymptomatic blood donors, Implicated In the transmission of viral hepatitis, were Inoculated Into 10 to 20 volunteers each. Five of these "Implicated" donor sera transmitted clinically apparent hepatitis to the recipients. The stored serum samples from these studies have been reanalyzed using serologic markers for hepatitis B virus and hepatitis A virus Infection. Two of the donor we were hepatitis B surface antigen (HBsAg)-positive, and both transmitted hepatitis B virus infection to all susceptible recipients, half of whom showed clinical symptoms. The remaining three Infectious donors were HBsAg-negative, yet were Icterogenic to 10% to 47% of recipients. Testing of serum samples from these recipients with hepatitis showed no evidence of hepatitis B virus or hepatitis A virus Infection. This study and other recent evidence suggest that there is a third type of human viral hepatitis--non-A, non-B hepatitis-which is due to a transmissible agent and may well be associated with a chronic carrier state. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS
KW  - COMMUNICABLE diseases
KW  - LIVER diseases
KW  - BLOOD donors
KW  - VIRAL hepatitis
KW  - SERUM
KW  - VIRUSES
N1  - Accession Number: 14147581; Hoofnagle, Jay H. 1,2; Gerety, Robert J. 1,2; Tabor, Edward 1,2; Feinstotne, Stephen M. 1,2; Barker, Lewellys F. 1,2; Purcell, Robert H. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p14; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: BLOOD donors; Subject: VIRAL hepatitis; Subject: SERUM; Subject: VIRUSES; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Reimer, Ronald R.
AU  - Chabner, Bruce A.
AU  - Young, Robert C.
AU  - Reddick, Robert
AU  - Johnson, Ralph E.
T1  - Lymphoma Presenting in Bone.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/07//
VL  - 87
IS  - 1
M3  - Article
SP  - 50
EP  - 55
SN  - 00034819
AB  - Lymphoma presenting in bone (that is "reticulum cell sarcoma of bone") is a form of extranodal lymphoma historically described as frequently localized (that is, stage IE or stage IlE). Between 1970 and 1975, 14 patients with this entity were seen at the National Cancer Institute. This group had a variety of histologic subtypes of diffuse lymphoma. Thorough staging showed extensive disease (stage IV) in 12 of these patients (86%). in 10 of these the metastatic disease was unsuspected clinically. Seven patients achieved complete remissions after treatment with combination chemotherapy alone (two patients), irradiation alone (one patient), surgery alone (one patient), and both chemotherapy and irradiation (three patients) and are alive and free of disease 11 + to 70 + months after diagnosis. The other seven patients did not achieve complete remission status and have all died. Although lymphomas presenting in bone may occasionally be localized, careful staging in this series frequently showed extensive disease and altered the therapeutic approach. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOMAS
KW  - RETICULO-endothelial system -- Tumors
KW  - BONE
KW  - CONNECTIVE tissues
KW  - SARCOMA
KW  - RETICULUM cell sarcoma
KW  - DRUG therapy
N1  - Accession Number: 14150848; Reimer, Ronald R. 1; Chabner, Bruce A. 1; Young, Robert C. 1; Reddick, Robert 1; Johnson, Ralph E. 1; Source Information: Jul77, Vol. 87 Issue 1, p50; Subject: LYMPHOMAS; Subject: RETICULO-endothelial system -- Tumors; Subject: BONE; Subject: CONNECTIVE tissues; Subject: SARCOMA; Subject: RETICULUM cell sarcoma; Subject: DRUG therapy; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Meyers, Joel D.
AU  - Jules L. Dienstag
AU  - Robert H. Purcell
AU  - E. Donnall Thomas
AU  - King K. Holmes
T1  - Parenterally Transmitted Non-A, Non-B Hepatitis.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/07//
VL  - 87
IS  - 1
M3  - Article
SP  - 57
EP  - 59
SN  - 00034819
AB  - in 1912 a nosocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. Because of the characteristics of the clinical illness, the Incubation period of 27 days, and the effect of Immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis A; there was no serologic evidence of either hepatitis B virus or cytomegalovirus infection. Stored serums from this outbreak were re-examined by more recently developed serologic techniques for evidence of hepatitis A (HA) virus infection. Ten patients and donors had undetectable anti-HA titers before illness and none seroconverted; five persons had pre-existent anti-HA titers and showed no further rise in convalescent serums. The serum of one patient was inevaluable. With the availability of serologic techniques for the diagnosis of both hepatitis A and hepatitis B virus infections, it is clear that most cases of post-transfusion hepatitis are not due to either of these agents, and shorts incubation-period hepatitis can not be assumed to be hepatitis A without further investigation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS
KW  - COMMUNICABLE diseases
KW  - LIVER diseases
KW  - NOSOCOMIAL infections
KW  - IMMUNOGLOBULINS
KW  - CYTOMEGALOVIRUS diseases
KW  - HERPESVIRUS diseases
N1  - Accession Number: 14150883; Meyers, Joel D. 1,2,3; Jules L. Dienstag 1,2,3; Robert H. Purcell 1,2,3; E. Donnall Thomas 1,2,3; King K. Holmes 1,2,3; Source Information: Jul77, Vol. 87 Issue 1, p57; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: NOSOCOMIAL infections; Subject: IMMUNOGLOBULINS; Subject: CYTOMEGALOVIRUS diseases; Subject: HERPESVIRUS diseases; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Crystal, Ronald G.
T1  - Pathology of Disruptive Pulmonary Emphysema (Book).
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/07//
VL  - 87
IS  - 1
M3  - Book Review
SP  - 140
EP  - 140
SN  - 00034819
AB  - Reviews the book "Pathology of Disruptive Pulmonary Emphysema," by A. E. Anderson and Alvan G. Foraker.
KW  - PATHOLOGY of Disruptive Pulmonary Emphysema (Book)
KW  - ANDERSON, A. E.
KW  - FORAKER, Alvan G.
KW  - PULMONARY emphysema
KW  - NONFICTION
N1  - Accession Number: 14152277; Crystal, Ronald G. 1; Source Information: Jul77, Vol. 87 Issue 1, p140; Subject: PATHOLOGY of Disruptive Pulmonary Emphysema (Book); Subject: ANDERSON, A. E.; Subject: FORAKER, Alvan G.; Subject: PULMONARY emphysema; Subject: NONFICTION; Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Hoff, D. D.;
AU  - Penta, J. S.;
AU  - Helman, L. J.;
AU  - Slavik, M.;
T1  - Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration
CT  - Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration
JO  - Cancer Treat. Rep.
JF  - Cancer Treat. Rep.
Y1  - 1977/07/01/
VL  - 61
IS  - Jul
SP  - 745
EP  - 748
AD  - Div. of Cancer Treatment, National Cancer Institute, Bldg. 37, Rm. 6E12, Bethesda, Maryland 20014
N1  - Accession Number: 14-5778; Language: English; Trade Name: Citrovorum factor; Generic Name: Leucovorin; Chemical Name: Methotrexate--59-05-2 Leucovorin--58-05-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate and leucovorin (10:00); AHFS Class: Antineoplastic agents leucovorin and methotrexate; References: 12; Journal Coden: CCYPBY; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations
N2  - A review of 498 patients treated with high dose methotrexate (I) and leucovorin rescue revealed 29 drug related deaths. Until the important factors in those deaths are identified, the use of high dose I should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.
KW  - Methotrexate--and leucovorin-;
KW  - Leucovorin--and methotrexate-;
KW  - Toxicity--methotrexate and leucovorin--studies, retrospective, deaths, high dose with rescue, and recommendations;
KW  - Toxicity--leucovorin and methotrexate--studies, retrospective, deaths, high dose with rescue, and recommendations;
KW  - Dosage--methotrexate and leucovorin--toxicity, retrospective studies, deaths, high with rescue, and recommendations;
KW  - Antineoplastic agents--methotrexate and leucovorin--toxicity, retrospective studies, deaths, high dose with rescue, and recommendations;
KW  - Antineoplastic agents--leucovorin and methotrexate--toxicity, retrospective studies, deaths, high dose with rescue, and recommendations;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Ottesen, E. A.
AU  - Poindexter, R. W.
AU  - Hiatt, R. A.
T1  - 'Long--distance' lymphocyte study THE EFFECTS OF TRANSPORTING BLOOD ON LYMPHOCYTE BLASTOGENIC RESPONSES.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1977/07//
VL  - 29
IS  - 1
M3  - Article
SP  - 168
EP  - 172
PB  - Wiley-Blackwell
SN  - 00099104
AB  - A comparison of blastogenic responsiveness to antigens and mitogen by human lymphocytes was made between cells which had been processed for culture immediately following blood collection and cells obtained from blood collected 9-11 hr previously and transported via commercial airline from the patients' homes to our laboratory. There were no significant differences in the responses of transported and non-transported cells if the blood was maintained at ambient temperature during the period of shipment. Chilling the blood during transport, however, resulted both in decreased stimulation of the cells and increased `background' activity in unstimulated cultures. These findings indicate the feasibility of carrying out both limited immunological evaluations and extended periods of follow-up for patients located at considerable distances from a research laboratory. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - LEUCOCYTES
KW  - KILLER cells
KW  - BLOOD cells
KW  - T cells
KW  - BLOOD collection
N1  - Accession Number: 15945431; Ottesen, E. A. 1 Poindexter, R. W. 1 Hiatt, R. A. 2; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of AlIergy and  Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: San Juan Laboratories, Bureau of Laboratories, Center for Disease Control, San Juan, Puerto Rico.; Source Info: Jul1977, Vol. 29 Issue 1, p168; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: KILLER cells; Subject Term: BLOOD cells; Subject Term: T cells; Subject Term: BLOOD collection; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jacobowitz, David M.
T1  - CONTROLLING INFLUENCES OF THE AUTONOMIC NERVOUS SYSTEM.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1977/07//
VL  - 69
IS  - 1
M3  - Article
SP  - 106
EP  - 111
SN  - 0022202X
AB  - Recent information about the localization of sympathetic nerves and catecholamine-containing cells suggests sites of action not usually described in the neuroscience textbooks. In this study, we focused on the autonomic controls that affect ganglia, heart, gut, and chemoreceptors. As a result of some speculation derived mainly from histochemical observations and partially from physiologic data, we concluded that at the organ level the interplay between a nerve terminal-receptor serves as a local control. Additional controls may function at the ganglion level where catecholamine-containing chromaffin cells may serve as interneurons. We suggest that all peripheral catecholamine-containing elements which function in a modulatory role are not vital to the survival of the individual but rather serve as "fine tune" adjustment that do not involve the central nervous system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTONOMIC nervous system
KW  - CATECHOLAMINES
KW  - SENSORY ganglia
KW  - CHROMAFFIN cells
KW  - NEURONS
KW  - NERVOUS system
N1  - Accession Number: 12497906; Jacobowitz, David M. 1; Affiliation:  1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, U. S. A.; Source Info: Jul77, Vol. 69 Issue 1, p106; Subject Term: AUTONOMIC nervous system; Subject Term: CATECHOLAMINES; Subject Term: SENSORY ganglia; Subject Term: CHROMAFFIN cells; Subject Term: NEURONS; Subject Term: NERVOUS system; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12497906
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Price, Donald D.
AU  - Dubner, Ronald
T1  - MECHANISMS OF FIRST AND SECOND PAIN IN THE PERIPHERAL AND CENTRAL NERVOUS SYSTEMS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1977/07//
VL  - 69
IS  - 1
M3  - Article
SP  - 167
EP  - 171
SN  - 0022202X
AB  - Brief (< 2.0 sec) noxious heat pulses (peak temp = 51.5°C) programmed by a computer and generated by a contact thermode produced first and second pain in human subjects. Measurements of reaction time confirmed that these first and second pains were related to the conduction of impulses in Aδ heat nociceptive and C polymodal nociceptive afferents respectively. Estimates of psychophysical magnitude showed that when four identical heat pulses were applied to the same spot on the hand (interstimulus interval ≤ 80 sec), the first pain progressively decreased in perceived intensity whereas the second pain increased with interstimulus intervals of 3 sec or less. The first pain did not decrease if the location of the thermode was changed between each stimulus whereas the summation of the second pain increased under these conditions. Identical trains of noxious heat pulses partially suppressed the responses of Aδ and of C nociceptive afferents. These psychophysical observations and physiologic records indicate that the temporal suppression of heat-induced first pain is related to the suppression of Aδ heat nociceptors and that prolonged temporal summation of second pain is related to summation within the central nervous system. Aδ heat nociceptive afferents and C polymodal nociceptive afferents converge on two types of spinothalamic tract neurons: (1) wide dynamic-range neurons that receive input from non-nociceptive and nociceptive afferents. and (2) nociceptive-specific neurons. Since both types show summation of responses to repeated C fiber stimulation, they can account for summation of second pain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERIPHERAL nervous system
KW  - CENTRAL nervous system
KW  - HEAT pulses
KW  - HEAT transfer
KW  - THERMAL desorption
KW  - NERVOUS system
N1  - Accession Number: 12497942; Price, Donald D. 1 Dubner, Ronald 1; Affiliation:  1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Jul77, Vol. 69 Issue 1, p167; Subject Term: PERIPHERAL nervous system; Subject Term: CENTRAL nervous system; Subject Term: HEAT pulses; Subject Term: HEAT transfer; Subject Term: THERMAL desorption; Subject Term: NERVOUS system; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12497942
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Semmes, Josephine
AU  - Turner, Blair
T1  - EFFECTS OF CORTICAL LESIONS ON SOMATOSENSORY TASKS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1977/07//
VL  - 69
IS  - 1
M3  - Article
SP  - 181
EP  - 189
SN  - 0022202X
AB  - Lesions were made in the subdivisions of the postcentral gyrus and in related cortical areas of monkeys. After the operation, the monkeys were trained on six tactual discrimination problems, and their performance was compared with those of a normal control group. Severe and apparently permanent damage to the ability to perform all tasks was observed after the postcentral lesions, but little or no effects were seen after the removal of the motor cortex or of the posterior parietal lobule. Destruction of area 3 of the postcentral gyrus had the most serious consequences, the monkeys with this lesion being unable to learn any but the easiest descriminations. Lesions of area 1 or of area 2 resulted in an inferior performance of tasks which required information mainly from cutaneous or deep receptors, respectively. The results of these behavioral studies support and extend the anatomical and physiologic data that demonstrate that the postcentral gyrus consists of a core area, which receives the heaviest thalamic projection and is crucial to a broad range of somatosensory functions. flanked by areas selectively responsive to stimulation of the cutaneous or the deep receptors. The fact that lesions of areas closely connected to the postcentral gyrus by corticocortical fibers do not impair somatosensory discriminations suggests that the necessary abilities are based mainly on the relation with the thalamus rather than on interareal cortical integration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOMATOSENSORY evoked potentials
KW  - EVOKED potentials (Electrophysiology)
KW  - MONKEYS
KW  - MOTOR cortex
KW  - FRONTAL lobes
KW  - THALAMUS
N1  - Accession Number: 12497948; Semmes, Josephine 1,2 Turner, Blair 1,2; Affiliation:  1: Behavioral Sciences Research Branch, National Institute of Mental Health, Rockville, Maryland.  2: Department of Anatomy, Howard University Medical School, Washington, D. C., U. S. A.; Source Info: Jul77, Vol. 69 Issue 1, p181; Subject Term: SOMATOSENSORY evoked potentials; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: MONKEYS; Subject Term: MOTOR cortex; Subject Term: FRONTAL lobes; Subject Term: THALAMUS; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1523-1747.ep12497948
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lehr, Roland E.
AU  - Jerina, Donald M.
T1  - Relationships of quantum mechanical calculations, relative mutagenicity of benzom anthracene diol epoxides, and “bay region” concept of aromatic hydrocarbon carcinogenicity.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1977/07//
VL  - 2
IS  - 6
M3  - Article
SP  - 1259
EP  - 1265
SN  - 00984108
AB  - Evidence supporting the conclusion that 7,8‐dihydroxy‐9,10‐epoxy‐7,8,9,10‐tetra‐hydrobenzo[a]pyrenes are ultimate mutagenic and carcinogenic forms of benzo[a]‐pyrene (BP) is summarized. Quantum mechanical calculations that predict reactivity of diol epoxides derived from BP and other polycyclic aromatic hydrocarbons are described. The calculations predict that diol epoxides in which the oxirane ring forms part of a “bay region” of a tetrahydrobenzo ring should be the most reactive for a given aromatic hydrocarbon. Experiments with dihydrodiols and diol epoxides from benzo[a]anthracene (BA) are described. The ability to metabolically activate BA 3,4‐dihydrodiol to species much more mutagenic than those obtained from other BA dihydrodiols and the much greater mutagenicity of the diastereoisomeric 3,4‐diol‐1,2‐epoxides of 1,2,3,4‐tetrahydro BA relative to other diol epoxides of BA are in accord with predictions of the quantum mechanical calculations. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75456895; Lehr, Roland E. 1,2 Jerina, Donald M. 1; Affiliation:  1: Laboratory of Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland  2: Department of Chemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma, 73019; Source Info: Jul1977, Vol. 2 Issue 6, p1259; Number of Pages: 7p; Document Type: Article
L3  - 10.1080/15287397709529528
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Saffiotti, Umberto
T1  - Scientific bases of environmental carcinogenesis and cancer prevention: Developing an interdisciplinary science and facing its ethical implications.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1977/07//
VL  - 2
IS  - 6
M3  - Article
SP  - 1435
EP  - 1447
SN  - 00984108
AB  - Two distinct types of toxic effects are defined: (1) terminal toxic effects, characterized by early appearance, direct correlation of the intensity of induced pathology with the intensity of exposure, and manifestation of toxicity due to altered functional products, degeneration, or death of the target cells themselves, and (2) self‐replicating toxic effects, characterized by delayed appearance, direct correlation of the frequency of induced pathology with the intensity of exposure, independence of the intensity of induced pathology from the intensity of exposure, and manifestation of toxicity due to proliferation of a new altered cell population. Traditional toxicology deals with terminal effects, but is inadequate to deal with self‐replicating effects, for which a new toxicology is developing. New knowledge of cellular and molecular mechanisms of self‐replicating toxicity has revolutionary implications for the evaluation of environmental toxicology. The mechanisms of carcinogenesis represent an example at the somatic cell level of the general theory of biological evolution by chance events followed by the necessity of biological expression as outlined by Monod in 1970. The implications of modern biological knowledge were developed by Monod into the ethic of knowledge. The scientific method, based on the postulate of objectivity, rejects any confusion between knowledge and “values.” In toxicology, value judgment on societal consequences of discovering chemicobiological interactions should absolutely not interfere with the objective pursuit of scientific evidence. The relationship between etiology and ethics demands high professional and ethical standards, comparable to those accepted in forensic medicine. High quality standards of scientific methodology, provisions to avoid any conflict of interest, and the establishment of licensed laboratories are recommended. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75456909; Saffiotti, Umberto 1; Affiliation:  1: National Cancer Institute, National Institutes of Health, Experimental Pathology Branch, Carcinogenesis Program, Division of Cancer Cause and Prevention, Bethesda, Maryland, 20014; Source Info: Jul1977, Vol. 2 Issue 6, p1435; Number of Pages: 13p; Document Type: Article
L3  - 10.1080/15287397709529542
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DAVIS, GLENN C.
AU  - BUNNEY JR., WILLIAM E.
AU  - DEFRAITES, EMANUEL G.
AU  - KLEINMAN, JOEL E.
AU  - VAN KAMMEN, DANIEL P.
AU  - POST, ROBERT M.
AU  - WYATT, RICHARD J.
T1  - Intravenous Naloxone Administration in Schizophrenia and Affective Illness.
JO  - Science
JF  - Science
Y1  - 1977/07//7/1/1977
VL  - 197
IS  - 4298
M3  - Article
SP  - 74
EP  - 77
SN  - 00368075
AB  - Fourteen schizophrenic patients and five patients with affective disorders were given naloxone (0.4 to 10 milligrams) or placebo intravenously in a double-blind fashion. Physicians' ratings of hallucinations, mannerisms and posturing, conceptual disorganization, psychosis, and mood did not change significantly. A single item, unusual thought content, improved significantly on the naloxone day compared to the placebo, day. There was no improvement in mood in affectively ill patients rated either by themselves or by physicians. Naloxone did not markedly improve any patient studied, which suggests that the acute blockade of opiate receptors is not associated with global improvement in psychotic symptomatology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87465326; DAVIS, GLENN C. 1; BUNNEY JR., WILLIAM E. 1; DEFRAITES, EMANUEL G. 1; KLEINMAN, JOEL E. 2; VAN KAMMEN, DANIEL P. 3; POST, ROBERT M. 3; WYATT, RICHARD J. 2; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health; 3: Adult Psychiatry Branch, National Institute of Mental Health; Issue Info: 7/1/1977, Vol. 197 Issue 4298, p74; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2013-42989-013
AN  - 2013-42989-013
AU  - Brown, Bertram S.
T1  - Conflict and detente between social issues and clinical practice.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1977/07//
VL  - 47
IS  - 3
SP  - 466
EP  - 475
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Brown, Bertram S., National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2013-42989-013. PMID: 888923 Partial author list: First Author & Affiliation: Brown, Bertram S.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Business Meeting of the Annual Meeting of the American Orthopsychiatric Association, 1977, New York, NY, US. Conference Note: This research were presented at the aforementioned conference. Major Descriptor: Clinical Practice; Mental Health; Mental Health Personnel; Professional Development; Social Issues. Minor Descriptor: Advocacy; Conflict. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1977. 
AB  - The 'dual nature' of the mental health profession—embodied in the differences between advocates of social and clinical approaches to people's problems—is considered. It is suggested that the situation reflects realities of the world we live in, and that it contains both dilemma and opportunity. Areas in which social advocacy and clinical expertise have complemented each other are illustrated, and possibilities for constructive and creative conflict are suggested. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - conflict
KW  - mental health profession
KW  - clinical expertise
KW  - problem solving
KW  - reflects realities
KW  - social advocacy
KW  - 1977
KW  - Clinical Practice
KW  - Mental Health
KW  - Mental Health Personnel
KW  - Professional Development
KW  - Social Issues
KW  - Advocacy
KW  - Conflict
KW  - 1977
DO  - 10.1111/j.1939-0025.1977.tb01253.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42989-016
AN  - 2013-42989-016
AU  - Davenport, Yolande B.
AU  - Ebert, Michael H.
AU  - Adland, Marvin L.
AU  - Goodwin, Frederick K.
T1  - Couples group therapy as an adjunct to lithium maintenance of the manic patient.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1977/07//
VL  - 47
IS  - 3
SP  - 495
EP  - 502
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Davenport, Yolande B., Section on Psychiatry, LCS, 900 Rockville Pike, Clinical Center, Room 4S-239, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-42989-016. PMID: 196507 Partial author list: First Author & Affiliation: Davenport, Yolande B.; Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Couples Therapy; Drug Therapy; Group Psychotherapy; Mania. Minor Descriptor: Lithium. Classification: Affective Disorders (3211); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1977. 
AB  - Use of couples therapy groups in conjunction with lithium in the long-term management of married manic-depressive patients is described. Among bipolar patients on lithium, those in couples group therapy had more benign posthospital course than those given minimal support beyond medication. The structure and benefits of the couples group are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - couples group therapy
KW  - lithium maintenance
KW  - manic patient
KW  - medication
KW  - 1977
KW  - Bipolar Disorder
KW  - Couples Therapy
KW  - Drug Therapy
KW  - Group Psychotherapy
KW  - Mania
KW  - Lithium
KW  - 1977
DO  - 10.1111/j.1939-0025.1977.tb01256.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42989-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42989-036
AN  - 2013-42989-036
AU  - Wittman, Milton
T1  - Review of Crowding and behavior: The psychology of high-density living and Public places and private spaces: The psychology of work, play, and living environments.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1977/07//
VL  - 47
IS  - 3
SP  - 554
EP  - 556
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42989-036. Partial author list: First Author & Affiliation: Wittman, Milton; Social Work Education Branch, Division of Manpower and Training Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Crowding; Environmental Psychology; Individual Differences; Public Sector; Social Behavior. Minor Descriptor: Books; Home Environment; Psychology; Stress. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Freedman, Jonathan. Crowding and behavior: The psychology of high-density living=177 pp. $17.95. Viking Press, New York; 1976. Mehrabian, Albert. Public places and private spaces: The psychology of work, play, and living environments=354 pp. $15.95. Basic Books, New York; 1976. Page Count: 3. Issue Publication Date: Jul, 1977. 
AB  - Reviews the books, Crowding and Behavior: The Psychology of High-Density Living by Jonathan Freedman (1976) and Public Places and Private Spaces: The Psychology of Work, Play, and Living Environments by Albert Mehrabian (1976). The two books under review represent quite different reports on the now familiar topic of environment, ecology, and human behavior. Taken together, they provide an unusually comprehensive overview of environmental psychology. The Mehrabian work, in contrast, represents a very general overview of a wide variety of psychological, ethological, and social relationships to the environment, and contains a wide-ranging discussion of how these are applied to knowledge about the impact of the environment on individual and social behavior. In the early part of his book, Mehrabian amplifies on what is called the General Adaptation Syndrome (GAS) . This is seen as a means of assessing psychosocial reactions to given environmental situations. The General Adaptation Syndrome is affected by 'high loading' and 'low loading' in all experiences. One can assume that almost any experience in life, whether it relates to work, play, education, or recreation, has environmental implications. In attempting to cover a wide range of topics, the author treats some rather superficially. Additional references at the end of each chapter are a helpful resource. The Freedman book is less easily read but does contain some in-depth reporting on research dealing with crowding and behavior. Both books certainly warrant scrutiny on the part of those in the helping and design professions who wish to become more informed about the physical environment in which they and their clients live and work. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - crowding
KW  - behavior
KW  - psychology
KW  - public places
KW  - environmental implications
KW  - social behavior
KW  - individual differences
KW  - 1977
KW  - Crowding
KW  - Environmental Psychology
KW  - Individual Differences
KW  - Public Sector
KW  - Social Behavior
KW  - Books
KW  - Home Environment
KW  - Psychology
KW  - Stress
KW  - 1977
U2  - Freedman, Jonathan. (1976); Crowding and behavior: The psychology of high-density living; 177 pp. $17.95. Viking Press, New York
U2  - Mehrabian, Albert. (1976); Public places and private spaces: The psychology of work, play, and living environments; 354 pp. $15.95. Basic Books, New York
DO  - 10.1037/h0099039
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42989-036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Wallace, R. B.;
AU  - Hoover, J.;
AU  - Sandler, D.;
AU  - Rifkind, B. M.;
AU  - Tyroler, H. A.;
T1  - Altered plasma lipids associated with oral contraceptive or estrogen consumption
CT  - Altered plasma lipids associated with oral contraceptive or estrogen consumption
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1977/07/02/
VL  - 2
IS  - Jul 2
SP  - 11
EP  - 14
SN  - 00237507
AD  - Lipid Metabolism Branch, Div. of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland
N1  - Accession Number: 15-0131; Language: English; References: 21; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Mean plasma cholesterol and triglyceride concentrations were measured in white female users and nonusers of oral contraceptives and estrogens in 10 diverse, demographically defined North American populations. A total of 18,461 women between the ages of 15 and 74 was studied. About 50% of the younger women (20-24 yr old) were taking oral contraceptives. In these women mean triglyceride concentrations were about 5% higher than in nonusers. The 95% percentile of the total lipid distribution among nonusers was used to define hyperlipidemia. In young women on oral contraceptives, hypercholesterolemia was up to 3 times more common and hypertriglyceridemia was up to 5 times more common than in nonusers. Of older women (50-54 yr) 37% (presumably intramenopausal and postmenopausal) were hormone users, and in this group there were small, inconsistent alterations in plasma triglyceride and a modest but consistent reduction in mean cholesterol concentration.
KW  - Contraceptives, oral--effects--plasma cholesterol and triglyceride levels, patients;
KW  - Estrogens--effects--plasma cholesterol and triglyceride levels, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - MYERS, CHARLES E.
AU  - MCGUIRE, WILLIAM P.
AU  - LISS, ROBERT H.
AU  - IFRIM, INA
AU  - GROTZINGER, KAREN
AU  - YOUNG, ROBERT C.
T1  - Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response.
JO  - Science
JF  - Science
Y1  - 1977/07/08/
VL  - 197
IS  - 4299
M3  - Article
SP  - 165
EP  - 167
SN  - 00368075
AB  - The antitumor antibiotic, adriamycin, induces severe cardiac toxicity associated with peroxidation of cardiac lipids in mice. Both this lipid peroxidation and cardiac toxicity of adriamycin are reduced by prior treatment of the animals with the free radical scavenger tocopherol. Such treatment with tocopherol does not, however, alter the magnitude or duration of the adriamycin-induced suppression of DNA synthesis in P388 ascites tumor, nor does it diminish the antitumor responsiveness of P388 ascites tumor. These results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which involves binding to DNA, is not antagonized by tocopherol and is responsible for tumor response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87465360; MYERS, CHARLES E. 1; MCGUIRE, WILLIAM P. 2; LISS, ROBERT H. 3; IFRIM, INA 3; GROTZINGER, KAREN 4; YOUNG, ROBERT C. 4; Affiliations: 1: Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Combined Modalities Branch, National Cancer Institute; 3: Arthur D. Little, Inc., Cambridge, Massachusetts 02166; 4: Medicine Branch, National Cancer Institute; Issue Info: 7/8/1977, Vol. 197 Issue 4299, p165; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ZATZ, MARTIN
AU  - O'DEA, ROBERT F.
T1  - Efflux of Cyclic Nucleotides from Rat Pineal: Release of Guanosine 3′, 5′-Monophosphate from Sympathetic Nerve Endings.
JO  - Science
JF  - Science
Y1  - 1977/07/08/
VL  - 197
IS  - 4299
M3  - Article
SP  - 174
EP  - 176
SN  - 00368075
AB  - Potassium and norepinephrine stimulate the efflux of adenosine 3′,5′-monophosphate (cyclic AMP) and guanosine 3′,5′-monophosphate (cyclic GMP) from intact pineal glands. The postsynaptic β-adrenergic receptor mediates the efflux of cyclic AMP. In contrast, the efflux of cyclic GMP requires calcium and intact nerve endings. It appears that sympathetic nerve endings may release cyclic GMP into the synaptic space. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87465365; ZATZ, MARTIN 1; O'DEA, ROBERT F. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 7/8/1977, Vol. 197 Issue 4299, p174; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LERNER, PAULINE
AU  - NOSE, PETER
AU  - GORDON, EDNA K.
AU  - LOVENBERG, WALTER
T1  - Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and Turnover.
JO  - Science
JF  - Science
Y1  - 1977/07/08/
VL  - 197
IS  - 4299
M3  - Article
SP  - 181
EP  - 183
SN  - 00368075
AB  - The short- and long-term effects of neuroleptic. drugs differ both clinically and biochemically. Short-term treatment with such a drug causes a kinetic activation of striatal tyrosine hydroxylase. Long-term treatment causes a prompt activation of the enzyme which is followed by a delayed, compensatory deactivation below control levels. Tolerance also develops to the stimulating effect of haloperidol on striatal dopamine turnover. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87465368; LERNER, PAULINE 1; NOSE, PETER 1; GORDON, EDNA K. 2; LOVENBERG, WALTER 1; Affiliations: 1: Section on Biochemical Pharmacology, Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 7/8/1977, Vol. 197 Issue 4299, p181; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ziegler, J. L.;
T1  - Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience
CT  - Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1977/07/14/
VL  - 297
IS  - Jul 14
SP  - 75
EP  - 80
SN  - 00284793
AD  - Clinical Oncology Program, Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 15-0081; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Methotrexate--59-05-2 Vincristine--57-22-7 Prednisolone--50-24-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents prednisolone; References: 25; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - Fifty-four Americans with Burkitt's lymphoma were treated with 2 sequential combined treatment regimens based upon therapeutic approaches from clinical trials in Africa. One treatment regimen consisted of cyclophosphamide, methotrexate and vincristine. The other treatment regimen consisted of cyclophosphamide, methotrexate, prednisolone and vincristine. Chemotherapy courses in both protocols were administered IV or intrathecally at intervals determined by recovery of the peripheral white cell count to 4500/cu mm. Four patients died during induction therapy, and 48 of the remaining 50 achieved complete remissions. Twenty-two relapsed at a median of 3 months from the start of therapy. The overall 2-yr actuarial survival was 54%: younger patients (\LT/ 12-yr-old) and patients with minimal tumor burden (stages A, B and AR) had significantly better survivals than older patients (P \LT/ 0.02) and patients with advanced abdominal tumors (stages C and D) (P \LT/ 0.01). No differences in survival were detected between patients treated at the National Institutes of Health and those treated in their regional institutions on either protocol. These results suggest that complete response rates, relapse frequency and survival in American patients are similar to results in Africa.
KW  - Cyclophosphamide--Burkitt's lymphoma-;
KW  - Methotrexate--Burkitt's lymphoma-;
KW  - Vincristine--Burkitt's lymphoma-;
KW  - Prednisolone--Burkitt's lymphoma-;
KW  - Dosage schedules--cyclophosphamide--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW  - Dosage schedules--methotrexate--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW  - Dosage schedules--vincristine--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW  - Dosage schedules--prednisolone--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW  - Combined therapy--cyclophosphamide--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW  - Combined therapy--methotrexate--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW  - Combined therapy--vincristine--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW  - Combined therapy--prednisolone--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW  - Antineoplastic agents--cyclophosphamide--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW  - Antineoplastic agents--methotrexate--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW  - Antineoplastic agents--vincristine--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW  - Antineoplastic agents--prednisolone--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW  - Race--antineoplastic agents--Burkitt's lymphoma, combined therapy, sequential dosage schedules, American patients;
KW  - Drug utilization--antineoplastic agents--Burkitt's lymphoma, combined therapy, sequential dosage schedules, American patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - NOBLE, ERNEST P.
T1  - Wine and Viral Diseases.
JO  - Science
JF  - Science
Y1  - 1977/07/15/
VL  - 197
IS  - 4300
M3  - Article
SP  - 208
EP  - 210
SN  - 00368075
N1  - Accession Number: 87459846; NOBLE, ERNEST P. 1; Affiliations: 1: National Institute on Alcohol Abuse and Alcoholism, Public Health Service, Rockville, Maryland 20852; Issue Info: 7/15/1977, Vol. 197 Issue 4300, p208; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - YOON SANG CHO-CHUNG
AU  - REDLER, BRUCE H.
T1  - Dibutyryl Cyclic AMP Mimics Ovariectomy: Nuclear Protein Phosphorylation in Mammary Tumor Regression.
JO  - Science
JF  - Science
Y1  - 1977/07/15/
VL  - 197
IS  - 4300
M3  - Article
SP  - 272
EP  - 275
SN  - 00368075
AB  - Growth of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene is arrested by either ovariectomy or treatment with N6, 02'-dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP). When this occurs, a new nonhistone protein species becomes the predominant endogenous substrate of cyclic AMP-dependent protein kinase in the tumor nuclei. Phosphorylation of this regression-associated protein ceases when resumption oftumor growth is induced by either the injection of 17,βestradiol or cessation of dibutyryl cyclic AMP treatment. Thus phosphorylation of regression-associated protein may play a role in the regression of hormone-dependent mammary tumors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87459828; YOON SANG CHO-CHUNG 1; REDLER, BRUCE H. 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/15/1977, Vol. 197 Issue 4300, p272; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Castelli, W. P.;
AU  - Gordon, T.;
AU  - Hjortland, M. C.;
AU  - Kagan, A.;
AU  - Doyle, J. T.;
AU  - \ET/;
T1  - Alcohol and blood lipids: Cooperative Lipoprotein Phenotyping Study
CT  - Alcohol and blood lipids: Cooperative Lipoprotein Phenotyping Study
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1977/07/23/
VL  - 2
IS  - Jul 23
SP  - 153
EP  - 155
SN  - 00237507
AD  - National Heart, Lung, and Blood Institute, Landow Bldg., Rm. C841, 7910 Woodmont Ave., Bethesda, Maryland 20014
N1  - Accession Number: 15-0432; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 20; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Data from 5 study populations (total of 3,806 patients) participating in the Cooperative Lipoprotein Phenotyping Study indicate strong relations between reported alcohol consumption and blood lipids. Alcohol consumption was positively associated with a high density lipoprotein cholesterol level in all populations (r from 0.16 to 0.30), the lipid level appearing to be a graded response even over the low levels of alcohol consumption reported. Less strong but consistently negative correlations were found with low density lipoprotein cholesterol. Plasma triglycerides showed a modest positive correlation with alcohol. The 5 populations were those of the Albany, Evans County, Framingham, Honolulu, and San Francisco Studies.
KW  - Alcohols, ethyl--effects-;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Reimer, R. R.;
AU  - Hoover, R.;
AU  - Fraumeni, J. F.;
AU  - Young, R. C.;
T1  - Acute leukemia after alkylating agent therapy of ovarian cancer
CT  - Acute leukemia after alkylating agent therapy of ovarian cancer
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1977/07/28/
VL  - 297
IS  - Jul 28
SP  - 177
EP  - 181
SN  - 00284793
AD  - Environmental Epidemiology Branch, Landow Bldg., Rm. A521, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 15-0030; Language: English; References: 40; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2  - To estimate the leukemogenic potential of alkylating agents, 70 institutions using these drugs for the frequency of second cancers in patients with advanced ovarian cancer were surveyed. Thirteen cases of acute nonlymphocytic leukemia occurred among 5,455 patients, as compared to 0.62 cases expected (relative risk = 21.0). All 13 had received alkylating agents. Nine also received radiotherapy. The relative risk for patients given chemotherapy was 36.1 and rose to 171.4 for those surviving for 2 years (rate = 13.75/1000 patients/year). To evaluate the role of therapy versus underlying disease, a historical control of 13,309 patients with ovarian cancer in the National Cancer Institute's End Results Program was analyzed. No excess of leukemia was noted in this group, even among 6,596 women receiving radiation. The excess of acute nonlymphocytic leukemia, therefore, appears attributable to alkylating agents, although the effect may be enhanced by exposure to radiation, as previously suggested for Hodgkin's disease.
KW  - Antineoplastic agents--toxicity--studies, leukemia, ovarian cancer patients;
KW  - Toxicity--antineoplastic agents--studies, leukemia, ovarian cancer patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - GEN
AU  - Penta, John S.
AU  - von Hoff, Daniel D.
AU  - Muggia, Franco M.
T1  - Hepatotoxicity of Combination Chemotherapy for Acute Myelocytic Leukemia.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/08//
VL  - 87
IS  - 2
M3  - Letter
SP  - 247
EP  - 248
SN  - 00034819
AB  - Presents a letter to the editor about hepatotoxicity of combination chemotherapy for acute myelocytic leukemia.
KW  - LETTERS to the editor
KW  - COMBINATION drug therapy
N1  - Accession Number: 14147192; Penta, John S. 1; von Hoff, Daniel D. 1; Muggia, Franco M. 1; Source Information: Aug77, Vol. 87 Issue 2, p247; Subject: LETTERS to the editor; Subject: COMBINATION drug therapy; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
TY  - GEN
AU  - Von Hoff, D. D.;
AU  - Rozencweig, M.;
AU  - Soper, W. T.;
AU  - Helman, L. J.;
AU  - Penta, J. S.;
AU  - \ET/;
T1  - Whatever happened to NSC? An analysis of clinical results of discontinued anticancer agents
CT  - Whatever happened to NSC? An analysis of clinical results of discontinued anticancer agents
JO  - Cancer Treat. Rep.
JF  - Cancer Treat. Rep.
Y1  - 1977/08/01/
VL  - 61
IS  - Aug
SP  - 759
EP  - 768
AD  - Div. of Cancer Treatment, National Cancer Institute, Building 10, Room 12N226, National Institutes of Health, Bethesda, Maryland 20014
N1  - Accession Number: 14-6374; Language: English; References: 146; Journal Coden: CCYPBY; Section Heading: Investigational Drugs
N2  - Twenty-six investigational anticancer drugs formerly supplied by the National Cancer Institute are no longer available due to the lack of requests for their use in clinical trials. This report examines the data on these drugs to determine how well they were clinically evaluated. Generally, the studies are incomplete, and 34% of the compounds were not studied beyond phase I trials. Clinical pharmacology data were not obtained for most of the drugs. In addition, the information available for drugs that did undergo phase II trials is grossly inadequate and does not permit a confident decision to withdraw them from investigational use. Instances of hints of activity and interesting drug properties are cited to stimulate further study. Finally, a list of compounds scheduled for future termination is given within the framework of this analysis to provoke thought toward obtaining more phase II data before these drugs fall into disuse.
KW  - Antineoplastic agents--drugs, investigational--clinical studies, analysis of discontinued INDs, 1975-1976, recommendations;
KW  - Drugs, investigational--antineoplastic agents--clinical studies, analysis of discontinued INDs, 1975-1976, recommendations;
KW  - Clinical studies--antineoplastic agents--drugs, investigational, analysis of discontinued INDs, 1975-1976, recommendations;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Kraemer, Kenneth H.
AU  - Weinstein, Gerald D.
T1  - DECREASED THYMIDINE INCORPORATION IN CIRCULATING LEUKOCYTES AFTER TREATMENT OF PSORIASIS WITH PSORALEN AND LONG-WAVE ULTRAVIOLET LIGHT.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1977/08//
VL  - 69
IS  - 2
M3  - Article
SP  - 211
EP  - 214
SN  - 0022202X
AB  - Tritiated thymidine incorporation, a measure of DNA synthesis, was studied in circulating leukocytes from patients with widespread psoriasis who were being treated with photochemotherapy using oral 8-methoxypsoralen (8-MOP) and high-intensity, long-wave ultraviolet light (UVA). Seven of 13 psoriasis patients treated with photochemotherapy demonstrated a significant (p < 0.05) reduction in leukocyte incorporation of tritiated thymidine immediately after UVA in comparison to incorporation before UVA. None of 10 control subjects treated with UVA alone demonstrated such reduction in leukocyte tritiated thymidine incorporation. Photochemotherapy thus affects circulating blood cells in some patients with psoriasis in addition to its therapeutic effect on epidermal cells. Further investigations are needed to determine the reasons for the differences in susceptibility to inhibition of leukocyte DNA synthesis among patients and the possible long-term consequences of such inhibition. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYMIDINE
KW  - LEUCOCYTES
KW  - PSORALENS
KW  - ULTRAVIOLET radiation -- Therapeutic use
KW  - PHOTOCHEMOTHERAPY
KW  - PSORIASIS
KW  - PATIENTS
KW  - DNA replication
N1  - Accession Number: 12506316; Kraemer, Kenneth H. 1,2 Weinstein, Gerald D. 2; Affiliation:  1: Department of Dermatology, University of Miami, School of Medicine, Miami, Florida.  2: Chemistry Branch, National Cancer Institute, Bethesda, Maryland, U. S. A.; Source Info: Aug77, Vol. 69 Issue 2, p211; Subject Term: THYMIDINE; Subject Term: LEUCOCYTES; Subject Term: PSORALENS; Subject Term: ULTRAVIOLET radiation -- Therapeutic use; Subject Term: PHOTOCHEMOTHERAPY; Subject Term: PSORIASIS; Subject Term: PATIENTS; Subject Term: DNA replication; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12506316
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - TING, C. C.
AU  - TSAI, S. C.
AU  - ROGERS, M. J.
T1  - Host Control of Tumor Growth.
JO  - Science
JF  - Science
Y1  - 1977/08/05/
VL  - 197
IS  - 4303
M3  - Article
SP  - 571
EP  - 573
SN  - 00368075
AB  - A humoral factor (molecular weight less than 60,000) that was present in the ascitic fluid of mice bearing intraperitoneal tumors and in pleural effusions from human cancer patients was found to promote the growth of a murine tumor and to suppress cell-mediated tumor immunity. However, the hosts that had recovered from the immunosuppressive state produced a serum factor that could neutralize the immunosuppressive effect. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519195; TING, C. C. 1; TSAI, S. C. 2; ROGERS, M. J. 3; Affiliations: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Cellular Metabolism, National Heart and Lung Institute, Bethesda, Maryland 20014; 3: Laboratory of Cell Biology, National Cancer Institute; Issue Info: 8/5/1977, Vol. 197 Issue 4303, p571; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Slater, S. L.;
AU  - Shiling, D. J.;
AU  - Lipper, S.;
AU  - Murphy, D. L.;
T1  - Elevation of plasma prolactin by monoamine oxidase inhibitors
CT  - Elevation of plasma prolactin by monoamine oxidase inhibitors
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1977/08/06/
VL  - 2
IS  - Aug 6
SP  - 275
EP  - 276
SN  - 00237507
AD  - Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20014
N1  - Accession Number: 15-0425; Language: English; Chemical Name: Pargyline--555-57-7; References: 8; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Joan Lentine
N2  - Plasma prolactin levels doubled in 10 depressive patients treated with the monoamine oxidase inhibitors, clorgyline and pargyline. Plasma prolactin levels were measured 4 times\M/twice (4 days apart) after 3 weeks on placebo and twice (4 days apart) after 3 weeks on either clorgyline (20-40 mg/day) or pargyline (75-150 mg/day). Five patients (3 women and 2 men) were studied on each drug. Both medications were given in divided doses, the last dose being no later than 15 hr before a blood sample was taken. The absence of significant changes in plasma cortisol in the same patients suggests that the increases in prolactin are not attributable to nonspecific effects of stress.
KW  - Clorgyline--effects-;
KW  - Pargyline--effects-;
KW  - Monoamine oxidase inhibitors--clorgyline--elevation, plasma prolactin levels, depressive patients;
KW  - Monoamine oxidase inhibitors--pargyline--elevation, plasma prolactin levels, depressive patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - PAUL, STEVEN M.
AU  - AXELROD, JULIUS
T1  - Catechol Estrogens: Presence in Brain and Endocrine Tissues.
JO  - Science
JF  - Science
Y1  - 1977/08/12/
VL  - 197
IS  - 4304
M3  - Article
SP  - 657
EP  - 659
SN  - 00368075
AB  - Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use ofa sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products. The concentration of catechol estrogens in the hypothalamus and pituitary are at least ten times higher than reported previously for the parent estrogens. Catechol estrogens have potent endocrine effects and, because of their normal occurrence in the hypothalamic-pituitary axis, they may have an important role in neuroendocrine regulation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87476550; PAUL, STEVEN M. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 8/12/1977, Vol. 197 Issue 4304, p657; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHULTZ, RICHARD M.
AU  - PAPAMATHEAKIS, JOSEPH D.
AU  - CHIRIGOS, MICHAEL A.
T1  - Interferon: An Inducer of Macrophage Activation by Polyanions.
JO  - Science
JF  - Science
Y1  - 1977/08/12/
VL  - 197
IS  - 4304
M3  - Article
SP  - 674
EP  - 676
SN  - 00368075
AB  - Purified mouse fibroblast interferon (IF) directly rendered resting macrophages tumoricidal. The physicochemical properties and species specificity of the stimulatory agent fall within the present definition of IF. Since a number of polyanions induce macrophage IF, the antitumor and antimicrobial activities may result from the ability of newly released IF to modify macrophage activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87476554; SCHULTZ, RICHARD M. 1; PAPAMATHEAKIS, JOSEPH D. 1; CHIRIGOS, MICHAEL A. 1; Affiliations: 1: Laboratory of RNA Tumor Viruses, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/12/1977, Vol. 197 Issue 4304, p674; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHLAGER, SEYMOUR I.
AU  - OHANIAN, SARKIS H.
T1  - Correlation Between Lipid Synthesis in Tumor Cells and Their Sensitivity to Humoral Immune Attack.
JO  - Science
JF  - Science
Y1  - 1977/08/19/
VL  - 197
IS  - 4305
M3  - Article
SP  - 773
EP  - 776
SN  - 00368075
AB  - Prolonged incubation of two antigenically distinct, chemically induced guinea pig hepatomas with relatively high concentrations of chemotherapeutic drugs or metabolic inhibitors increases their susceptibility to killing by antibody and complement. This effect is reversible when the cells are cultured in the absence of the drugs. The drug-induced sensitivity and the ability of the cells to recover their resistance to killing are directly correlated to their ability to synthesize complex lipids. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87459886; SCHLAGER, SEYMOUR I. 1; OHANIAN, SARKIS H. 1; Affiliations: 1: Laboratory of Immunobiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/19/1977, Vol. 197 Issue 4305, p773; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FIDLER, ISAIAH J.
AU  - KRIPKE, MARGARET L.
T1  - Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor.
JO  - Science
JF  - Science
Y1  - 1977/08/26/
VL  - 197
IS  - 4306
M3  - Article
SP  - 893
EP  - 895
SN  - 00368075
AB  - Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87476587; FIDLER, ISAIAH J. 1; KRIPKE, MARGARET L. 1; Affiliations: 1: Basic Research Program, National Cancer Institute Frederick Cancer Research Center, Frederick, Maryland 21701; Issue Info: 8/26/1977, Vol. 197 Issue 4306, p893; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bender, J. F.;
AU  - Grove, W. R.;
AU  - Fortner, C. L.;
T1  - High dose methotrexate with folinic acid rescue
CT  - High dose methotrexate with folinic acid rescue
JO  - American Journal of Hospital Pharmacy (USA)
JF  - American Journal of Hospital Pharmacy (USA)
Y1  - 1977/09/01/
VL  - 34
IS  - Sep
SP  - 962
EP  - 965
SN  - 00029289
AD  - Baltimore Cancer Research Center, National Cancer Institute, NIH, Univ. of Maryland Hosp., Baltimore, Maryland 21201
N1  - Accession Number: 14-5300; Language: English; Chemical Name: Methotrexate--59-05-2 Leucovorin--58-05-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 34; Journal Coden: AJHPA9; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - A brief review of the pharmacology of methotrexate is presented, and the rationale for the administration of high dose methotrexate and the necessity of a folinic acid (leucovorin) rescue to prevent methotrexate toxicity are discussed. Critical factors concerning the use of this therapy, as well as unusual toxicities associated with the use of high dose methotrexate, are presented. Several drug and patient related variables which may affect the toxicity of this dual drug administration are discussed to better enable pharmacists to monitor patients receiving this form of therapy. High dose methotrexate with folinic acid rescue has improved the therapeutic index of methotrexate. The optimal dosage and duration of the 2 agents are yet to be determined.
KW  - Methotrexate--toxicity-;
KW  - Leucovorin--prophylaxis-;
KW  - Toxicity--methotrexate--prophylaxis, leucovorin rescue, patients;
KW  - Antineoplastic agents--methotrexate--toxicity, prophylaxis, leucovorin rescue, patients;
KW  - Dosage--methotrexate--high, toxicity, prophylaxis, leucovorin rescue, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Gershengorn, Marvin C.
AU  - McClung, Michael R.
AU  - Chu, Elizabeth W.
AU  - Hanson, Thomas A. S.
AU  - Weintraub, Bruce D.
AU  - Robbins, Jacob
T1  - Fine-Needle Aspiration Cytology in the Preoperative Diagnosis of Thyroid Nodules.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/09//
VL  - 87
IS  - 3
M3  - Article
SP  - 265
EP  - 269
SN  - 00034819
AB  - Fifty consecutive patients were studied to assess the utility of fine-needle aspiration cytology for the diagnosis of hypofunctioning thyroid nodules. In two patients, cysts were evaculated and did not recur. Thirty-three patients underwent excisional biopsy; the aspiration biopsy result was not a briterion for surgery. Satisfactory aspiration specimens were obtained in 32 patients (97%). The diagnosis in espiration specimens was malignant; of these seven (78%) were correct and there was one false-positive and one occult carcinoma unrelated to the clinically detected nodule. Five aspirations showed suspected malignancy; of these, two were carcinoma, one was an occult carcinoma, and two were benign. Eighteen aspirations were interpreted as benign; of these 17 (94%) were correct and the one false-negative diagnosis was a well-differentiated follicular carcinoma. The procedure is useful in assessing the need for surgery in high-risk patients and in selecting patients for thyroid-suppression therapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEEDLE biopsy
KW  - PARACENTESIS
KW  - THYROID gland
KW  - CYTOLOGY
KW  - BIOLOGY
KW  - CLINICAL pathology
N1  - Accession Number: 14153392; Gershengorn, Marvin C. 1; McClung, Michael R. 1; Chu, Elizabeth W. 1; Hanson, Thomas A. S. 1; Weintraub, Bruce D. 1; Robbins, Jacob 1; Source Information: Sep77, Vol. 87 Issue 3, p265; Subject: NEEDLE biopsy; Subject: PARACENTESIS; Subject: THYROID gland; Subject: CYTOLOGY; Subject: BIOLOGY; Subject: CLINICAL pathology; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - NEWS
AU  - Mitchell, Jerry R.
T1  - Host Susceptibility and Acetaminophen Liver Injury.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1977/09//
VL  - 87
IS  - 3
M3  - Editorial
SP  - 377
EP  - 378
SN  - 00034819
AB  - For most patients and consumers of over-the counter drugs, acetaminophen is safe when used appropriately. It is a good antipyretic, effectively relieves mild and moderate pain, and has minor anti-inflammatory action. In overdosage the drug causes acute centrilobular hepatic necrosis that may be fatal, and acetaminophen poisoning is now one of the commonest causes of hepatic failure in Great Britain. The concentration of hepatic glutathione in various disease, dietary, and therapeutic situations is unknown, and the maximal synthetic capacity and availability of glutathione in human liver for detoxification has not been examined.
KW  - LIVER failure
KW  - ACETAMINOPHEN
KW  - GLUTATHIONE
KW  - NECROSIS
KW  - PATIENTS
KW  - DRUG abuse
N1  - Accession Number: 14154289; Mitchell, Jerry R. 1; Source Information: Sep77, Vol. 87 Issue 3, p377; Subject: LIVER failure; Subject: ACETAMINOPHEN; Subject: GLUTATHIONE; Subject: NECROSIS; Subject: PATIENTS; Subject: DRUG abuse; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - 
AU  - Gainer, Ruth Straus1
AU  - Gainer, Harold2
T1  - Educating Both Halves of the Brain: Fact or Fancy.
JO  - Art Education
JF  - Art Education
J1  - Art Education
PY  - 1977/09//
Y1  - 1977/09//
VL  - 30
IS  - 5
CP  - 5
M3  - Article
SP  - 20
EP  - 22
SN  - 00043125
AB  - The article focuses on the issue concerning the concept of cultivating both halves of the brain to pedagogical practice in the U.S. Educators are urged to balance the students' brains by educating the two hemispheres through various forms of activities relevant to logical and analytical exercises. In an attempt to evaluate the relevance of cerebral lateralization to education, both the educational and neurological literature have been examined. According to the authors, arts provide many possibilities for meeting the desired educational objective.
KW  - Art -- Study & teaching
KW  - Educational planning
KW  - Educational psychology
KW  - Cerebral hemispheres
KW  - Effective teaching
KW  - Educators
KW  - Teaching methods
KW  - Cerebral dominance
KW  - United States
N1  - Accession Number: 28741979; Authors: Gainer, Ruth Straus 1; Gainer, Harold 2; Affiliations:  1: Visual Arts Specialist, Project ARTS, Montgomery County Public Schools, Maryland;  2: Head, Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health And Human Development; Subject: Educational planning; Subject: Educational psychology; Subject: Cerebral hemispheres; Subject: Effective teaching; Subject: Educators; Subject: Art -- Study & teaching; Subject: Teaching methods; Subject: Cerebral dominance; Subject: United States; Number of Pages: 3p; Record Type: Article
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DP  - EBSCOhost
DB  - asu
ER  - 

TY  - JOUR
AU  - Wyler, D. J.
AU  - Brown, J.
T1  - Malaria antigen-specific T-cell responsiveness during infection with Plasmodium falciparum.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1977/09//
VL  - 29
IS  - 3
M3  - Article
SP  - 401
EP  - 407
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Protective immunity against Plasmodium falciparum develops only after several years of repeated exposure to the malarial parasite. We therefore investigated the possibility that acute malaria was associated with malarial antigen-specific immunosuppression. Peripheral lymphocytes of West Africans with and without P. falciparum infections were tested fur their in vitro proliferative responses to a preparation of P. falciparum antigen. There was no significant difference between the magnitude of the proliferative response of lymphocytes from infected as compared to normal Africans, although the responses from both African groups were significantly higher than responses from a group of European controls. Furthermore, no soluble inhibitor of antigen- specific proliferation was present in plasma of infected patients. These observations strongly suggest that if the sluggish development of protective immunity in malaria is based upon infection related immunosuppression, this occurs without affecting the proliferative responsiveness of specific sensitized, circulating T cells. Preliminary observations also indicate that Europeans residing in Africa and taking malaria prophylaxis may acquire sensitized T cells without experiencing clinically apparent infections. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PLASMODIUM falciparum
KW  - MALARIA
KW  - INFECTION
KW  - ANTIGENS
KW  - T cells
KW  - FEVER
N1  - Accession Number: 16142411; Wyler, D. J. 1 Brown, J. 2; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of  Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Medical Research Council Laboratories, Fajara, The Gambia, West Africa; Source Info: Sep1977, Vol. 29 Issue 3, p401; Subject Term: PLASMODIUM falciparum; Subject Term: MALARIA; Subject Term: INFECTION; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: FEVER; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ottesen, E.A.
AU  - Weller, P.F.
AU  - Heck, L.
T1  - Specific cellular immune unresponsiveness in human filariasis.
JO  - Immunology
JF  - Immunology
Y1  - 1977/09//
VL  - 33
IS  - 3
M3  - Article
SP  - 413
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Investigates specific cellular immune unresponsiveness in human filariasis.  Observation that the poor cellular responsiveness of infected individuals was filaria antigen-specific, as reactivity to tuberculin and streptococcal antigens; Data indicating that a state of antigen-specific cellular unresponsiveness in patients with this chronic parasitic infection and speculate that this immunologic deficit may be of fundamental importance in the pathogenesis of filarial disease.
KW  - FILARIASIS
KW  - TUBERCULIN
KW  - ANTIGENS
N1  - Accession Number: 11179402; Ottesen, E.A. 1 Weller, P.F. 1 Heck, L. 1; Affiliation:  1: Laboratory of Parasitic Diseases and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Sep77, Vol. 33 Issue 3, p413; Subject Term: FILARIASIS; Subject Term: TUBERCULIN; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
ID  - 83991222
T1  - Sound advice for conducting clinical trials.
AU  - Byar, David P.
AU  - Byar, D P
Y1  - 1977/09/08/
N1  - Accession Number: 83991222. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: clinical trial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). NLM UID: 0255562. 
KW  - Study Design
KW  - Therapeutics
KW  - Human
KW  - Clinical Trials
KW  - Statistics
KW  - United States
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Scales
SP  - 553
EP  - 554
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 297
IS  - 10
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Cancer Institute Bethesda, MD 20014
U2  - PMID: 329129.
DO  - 10.1056/NEJM197709082971009
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - SCHWARTZ, WILLIAM J.
AU  - GAINER, HAROLD
T1  - Suprachiasmatic Nucleus: Use of 14C-Labeled Deoxyglucose Uptake as a Functional Marker.
JO  - Science
JF  - Science
Y1  - 1977/09/09/
VL  - 197
IS  - 4308
M3  - Article
SP  - 1089
EP  - 1091
SN  - 00368075
AB  - Glucose consumption of the rat suprachiasmatic nuclei (SCN) was studied under various experimental conditions by means of the [14C]deoxyglucose (DG) technique. The results show that glucose consumption of the SCN, in contrast to other brain structures, is a function of both the time of day and environmental lighting conditions. These data are consistent with the hypothesis that the SCN have an essential role in circadian rhythm regulation and indicate that the DG technique may provide a novel approach for the study of the central neural mechanisms underlying circadian rhythm regulation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87476671; SCHWARTZ, WILLIAM J. 1; GAINER, HAROLD 2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda 20014; Issue Info: 9/9/1977, Vol. 197 Issue 4308, p1089; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hoover, R.;
AU  - Gray, L. A.;
AU  - Fraumeni, J. F.;
T1  - Stilbestrol (diethylstilbestrol) and the risk of ovarian cancer
CT  - Stilbestrol (diethylstilbestrol) and the risk of ovarian cancer
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1977/09/10/
VL  - 2
IS  - Sep 10
SP  - 533
EP  - 534
SN  - 00237507
AD  - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1  - Accession Number: 15-0956; Language: English; Trade Name: Premarin; Generic Name: Estrogenic substances; Chemical Name: Diethylstilbestrol--56-53-1; References: 12; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Interactions
N2  - A follow-up survey of 908 women who had received Premarin (conjugated equine estrogen) for menopausal symptoms revealed 9 cases of ovarian cancer. This risk was 2 to 3 times greater than expected. The risk increased with the strength of Premarin tablet usually taken, but not with the duration of use or total dose ingested. The excess risk of ovarian cancer in this group occurred primarily among 21 women who had also used diethylstilbestrol. The results of this small trial are consistent with the increasing incidence of ovarian cancer in American postmenopausal women, and with the occurrence of stilbestrol induced ovarian neoplasms in dogs.
KW  - Diethylstilbestrol--toxicity-;
KW  - Estrogenic substances--conjugated--toxicity, studies, ovarian cancer, patients who had also taken diethylstilbestrol;
KW  - Toxicity--estrogenic substances--conjugated, studies, ovarian cancer, patients who had also taken diethylstilbestrol;
KW  - Toxicity--diethylstilbestrol--studies, ovarian cancer, patients who had also taken estrogenic substances, conjugated;
KW  - Drug interactions--estrogenic substances, conjugated and diethylstilbestrol--possible, ovarian cancer, patients;
KW  - Drug interactions--diethylstilbestrol and estrogenic substances, conjugated--possible, ovarian cancer, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - STEPHEN, E. L.
AU  - HILMAS, D. E.
AU  - MANGIAFICO, J. A.
AU  - LEVY, H. B.
T1  - Swine Influenza Virus Vaccine: Potentiation of Antibody Responses in Rhesus Monkeys.
JO  - Science
JF  - Science
Y1  - 1977/09/23/
VL  - 197
IS  - 4310
M3  - Article
SP  - 1289
EP  - 1290
SN  - 00368075
AB  - Polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose [poly(ICLC)] enhances the antibody response in rhesus monkeys immunized with swine influenza virus subunit vaccine. Monkeys given the vaccine-adjuvant combination had earlier and significantly (P < .05) higher titers by 14 days compared to those that received vaccine alone. The potentiation of the antibody response of young monkeys given a split-virus vaccine in combination with poly(ICLC) suggests that this vaccine-adjuvant combination may similarly provide a potentially useful alternative approach to the immunization of pediatric and young adult age groups against swine influenza. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87459924; STEPHEN, E. L. 1; HILMAS, D. E.; MANGIAFICO, J. A. 1; LEVY, H. B. 2; Affiliations: 1: U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701; 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 9/23/1977, Vol. 197 Issue 4310, p1289; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Parlin, Leonard I.
AU  - Johnson, Joyce S.
T1  - MARITAL STATUS, LIFE-STRAINS AND DEPRESSION.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1977/10//
VL  - 42
IS  - 5
M3  - Article
SP  - 704
EP  - 715
SN  - 00031224
AB  - The relationship between marital status and psychological distress, consistently documented by a variety of studies, traditionally has been interpreted as reflecting the unmet inner needs and emotional frustrations of never married and formerly married people. In contrast, the present study examines the depressive consequences of economic hardship, social isolation and parental responsibilities as three durable, structured conditions of life to which unmarried people are both more exposed and more vulnerable. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MARITAL status
KW  - DISTRESS (Psychology)
KW  - SOCIAL isolation
KW  - MARRIAGE
KW  - EMOTIONS (Psychology)
KW  - SOCIAL psychology
N1  - Accession Number: 14764148; Parlin, Leonard I. 1; Johnson, Joyce S. 2; Affiliations: 1: National Institute of Mental Health.; 2: U. S. Department of Labor.; Issue Info: Oct77, Vol. 42 Issue 5, p704; Subject Term: MARITAL status; Subject Term: DISTRESS (Psychology); Subject Term: SOCIAL isolation; Subject Term: MARRIAGE; Subject Term: EMOTIONS (Psychology); Subject Term: SOCIAL psychology; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Langley, Charles H.
T1  - A LITTLE DARWINISM….
JO  - BioScience
JF  - BioScience
Y1  - 1977/10//
VL  - 27
IS  - 10
M3  - Book Review
SP  - 692
EP  - 692
SN  - 00063568
AB  - The article reviews the book "The Selfish Gene," by Richard Dawkins.
KW  - Evolution (Biology)
KW  - Fiction
KW  - Dawkins, Richard, 1941-
KW  - Selfish Gene, The (Book)
N1  - Accession Number: 28049918; Langley, Charles H. 1; Affiliations: 1 : National Institute of Environmental Health Sciences, Laboratory of Environmental, Mutagenesis Research, Triangle Park, NC 27709;  Source Info: Oct1977, Vol. 27 Issue 10, p692; Thesaurus Term: Evolution (Biology); Subject Term: Fiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 354
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Bender, R. A.;
AU  - Castle, M. C.;
AU  - Margileth, D. A.;
AU  - Oliverio, V. T.;
T1  - Pharmacokinetics of (\SU/3\BS/H)-vincristine in man
CT  - Pharmacokinetics of (\SU/3\BS/H)-vincristine in man
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1977/10/01/
VL  - 22
IS  - Oct
SP  - 430
EP  - 438
SN  - 00099236
AD  - Med. Branch and Office of the Director for Experimental Therapeutics, National Cancer Institute, 9000 Rockville Pike, Bldg. 10, Rm. 12N226, Bethesda, MD 20014
N1  - Accession Number: 15-1581; Language: English; Chemical Name: Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents vincristine; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2  - The pharmacokinetics, metabolism, and excretion of aromatically labeled tritiated vincristine (I) were examined in 4 patients. Clearance of radioactivity from the blood was triphasic with half-life t1/2 values of 0.85, 7.4, and 164 min. The initial phases probably represent distribution and binding to formed blood elements which exceeded 50% of the administered dose by 20 min. Excretion of radioactivity was principally fecal, with 33% recovered in the feces by 24 hr and 69% by 72 hr. Considerably less radioactivity (12%) was excreted in the urine over the 72 hr period. Approximately 40% of fecally excreted and 46% of urinary excreted radiolabel represented metabolites, which suggests that at least 34% of the I dose was excreted as metabolites. Plasma metabolites represented from less than one percent to 30% or more of radioactivity in plasma. UV spectral analysis of all metabolites revealed preservation of the intact I dimer, which suggests that metabolism involves alteration of side groups.
KW  - Vincristine--pharmacokinetics-;
KW  - Pharmacokinetics--vincristine--blood levels, and excretion, patients;
KW  - Excretion--vincristine--urinary, patients;
KW  - Half-life--vincristine--blood levels, patients;
KW  - Blood levels--vincristine--half-life, patients;
KW  - Antineoplastic agents--vincristine--pharmacokinetics, patients;
KW  - Drugs, body distribution--vincristine--pharmacokinetics, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Korts, David C.
T1  - Analysis of caries clinical trial data in the presence of study group imbalance.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1977/10//
VL  - 5
IS  - 5
M3  - Article
SP  - 231
EP  - 236
SN  - 03015661
AB  - Imbalance of any important factor in caries clinical trials can bias group means, and make decisions based on such means of questionable value. Six hypothetical trials are presented which have varying degrees of imbalance in baseline DMFS. The crude group means for these trials vary radically, from one extreme in which tile treated group has significantly less decay than the control group, to the opposite extreme in which the control group has significantly less decay than the treated group. Two methods for adjustment to correct for the imbalances, the analysis of covariance and blocking analysis, are discussed and applied to each trial. For these data sets the blocking analysis appears superior to the analysis of covariance in terms of maintaining the essential character of the data. An appendix explaining in detail how the blocking analysis is performed can be obtained on request to the author. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL caries
KW  - CLINICAL trials
KW  - RESEARCH
KW  - CLINICAL medicine -- Research
KW  - METHODOLOGY
KW  - DENTAL pathology
KW  - clinical trial
KW  - dental caries
N1  - Accession Number: 12105185; Korts, David C. 1; Affiliation:  1: Biometry Section, National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct1977, Vol. 5 Issue 5, p231; Subject Term: DENTAL caries; Subject Term: CLINICAL trials; Subject Term: RESEARCH; Subject Term: CLINICAL medicine -- Research; Subject Term: METHODOLOGY; Subject Term: DENTAL pathology; Author-Supplied Keyword: clinical trial; Author-Supplied Keyword: dental caries; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12105185
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Oxambra, Leonard M.
T1  - INDEPENDENT DIMENSIONS OF DEPRESSION: A FACTOR ANALYSIS OF THREE SELF-REPORT DEPRESSION MEASURES.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1977/10//
VL  - 33
IS  - 4
M3  - Article
SP  - 928
EP  - 935
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - Covariance studies of objective depression measures have concentrated on total scores. This approach is relatively insensitive in specifying whether these instruments measure the same sub-aspects of depression. To investigate this question, a factor analysis was performed on the items of the Beck Depression Inventory and the Zung Self-Rating Depression Scale and lists .A, B, C, and D of the Lubin Depression Adjective Check Lists. Ss were 91 college students and 29 correctional institution inmates. Four clearly interpretable multimeasure factors resulted from a Varimax rotation. The most salient factor was labeled "Depression: Affective Malaise." Earlier studies also have shown this to be a dominant and reliable dimension of depression. The other factors were: "Suicidal Ambivalence," "Appetite-Weight Loss," and "Fatigability." Females showed greater Fatigability associated with depression. Factors specific to the Beck and Zung measures also were found, which suggests that the different emphases of these instruments, intensity/severity vs. frequency of symptoms, may contribute very specific depression indicators. This may indicate that both intensity and frequency of symptoms ought to be considered to obtain a "best" objective measure of depression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL depression
KW  - MENTAL depression -- Diagnosis
KW  - CLINICAL psychology
KW  - PSYCHOLOGICAL tests
N1  - Accession Number: 15866684; Oxambra, Leonard M. 1; Affiliation:  1: National Institute on Aging Baltimore, Maryland; Source Info: Oct1977, Vol. 33 Issue 4, p928; Subject Term: MENTAL depression; Subject Term: MENTAL depression -- Diagnosis; Subject Term: CLINICAL psychology; Subject Term: PSYCHOLOGICAL tests; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BLOT, WILLIAM J.
AU  - BRINTON, LOUISE A.
AU  - FRAUMENI, JR., JOSEPH F.
AU  - STONE, B. J.
T1  - Cancer Mortality in U.S. Counties with Petroleum Industries.
JO  - Science
JF  - Science
Y1  - 1977/10/07/
VL  - 198
IS  - 4312
M3  - Article
SP  - 51
EP  - 53
SN  - 00368075
AB  - A survey of cancer mortality from 1950 to 1969 was conducted in U.S. counties where the petroleum industry is most heavily concentrated. Male residents of these counties experienced significantly higher rates for cancers of the lung, the nasal cavity and sinuses, and the skin (including malignant melanoma) compared to male residents ofcounties with similar demographic characteristics. Further study is needed to determine whether these patterns result from exposure to chemical carcinogens, including polycyclic hydrocarbons, involved in the manufacturing of petroleum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87459981; BLOT, WILLIAM J. 1; BRINTON, LOUISE A. 1; FRAUMENI, JR., JOSEPH F. 1; STONE, B. J. 1; Affiliations: 1: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/7/1977, Vol. 198 Issue 4312, p51; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Claxton, Larry D.
AU  - Barry, Patricia Z.
T1  - Chemical Mutagenesis: An Emerging Issue For Public Health.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1977/11//
VL  - 67
IS  - 11
M3  - Article
SP  - 1037
PB  - American Public Health Association
SN  - 00900036
AB  - Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MUTAGENS
KW  - MUTAGENESIS
KW  - MUTATION (Biology)
KW  - PUBLIC health
KW  - TEST systems
KW  - TEST methods
KW  - FEDERAL regulation
KW  - DELEGATED legislation
KW  - FEDERAL government
N1  - Accession Number: 5662300; Claxton, Larry D. 1 Barry, Patricia Z. 2; Affiliation:  1: Biologist, National Institute of Environmental Health Sciences, Research Triangle Park, NC  2: Assistant Professor, Department of Health Administration, UNC School of Public Health, Chapel Hill, NC 27514; Source Info: Nov77, Vol. 67 Issue 11, p1037; Subject Term: MUTAGENS; Subject Term: MUTAGENESIS; Subject Term: MUTATION (Biology); Subject Term: PUBLIC health; Subject Term: TEST systems; Subject Term: TEST methods; Subject Term: FEDERAL regulation; Subject Term: DELEGATED legislation; Subject Term: FEDERAL government; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ahmed, A.
AU  - Smith, A.H.
AU  - Sell, K.W.
AU  - Gershwin, M.E.
AU  - Steinberg, A.D.
AU  - Thurman, G.B.
AU  - Goldstein, A.L.
T1  - Thymic-dependent anti-hapten response in congenitally athymic (nude) mice immunized with DNP-thymosin.
JO  - Immunology
JF  - Immunology
Y1  - 1977/11//
VL  - 33
IS  - 5
M3  - Article
SP  - 757
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Reports on the finding that immunization of congenitally athymic (nu/nu) and adult thymectomized, irradiated bone marrow, reconstituted (TxBm) mice with DNP[sub 5]-thymosin, elicited immunoglobulin (Ig)M and IgG anti-DNP plaque-forming cells in the animals.  Function of DNP-thymosin both as a hormone and as a T-dependent antigen in eliciting an immune response in nu/nu and TcBm mice.
KW  - BONE marrow
KW  - THYMOSIN
KW  - IMMUNOGLOBULIN M
KW  - IMMUNOGLOBULIN G
N1  - Accession Number: 11185159; Ahmed, A. 1 Smith, A.H. 1 Sell, K.W. 1 Gershwin, M.E. 2 Steinberg, A.D. 3 Thurman, G.B. 4 Goldstein, A.L. 4; Affiliation:  1: Cellular Immunology Division, Department of Clinical and Experimental Immunology, Naval Medical Research Institute, Maryland  2: Section of Rheumatology, Department of Internal Medicine, School of Medicine, University of California  3: Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Maryland  4: Division of Biochemistry, University of Texas Medical Branch; Source Info: Nov77, Vol. 33 Issue 5, p757; Subject Term: BONE marrow; Subject Term: THYMOSIN; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNOGLOBULIN G; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Peck, Gary L.
AU  - Elias, Peter M.
AU  - Wetzel, Bruce
T1  - EFFECTS OF RETINOIC ACID ON EMBRYONIC CHICK SKIN.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1977/11//
VL  - 69
IS  - 5
M3  - Article
SP  - 463
EP  - 476
SN  - 0022202X
AB  - The influence of vitamin A on differentiating epithelia was examined in explants of skin from 14-day chick embryos exposed to retinoic acid (RA) in low, moderate, and high doses. The changes observed in RA-treated cultures are both dose- and time-dependent and are reversible when explants are transferred to control medium. The periderm sloughs prematurely and horizontal stratification is lost. Keratinization is inhibited and fewer desmosomes and tonofilaments are seen. Surface epidermal cells develop microvilli, bulge upwards, and detach. Golgi elements, rough endoplasmic reticulum, and polyribosomes are unusually prominent. Mucin granules form and gland-like structures develop with intercellular canaliculi characterized by tight junctions, brush borders, and dense secretory contents. On the basis of present evidence there are several possible mechanisms by which RA could alter epidermal differentiation. RA-induced gaps in the basal lamina allow direct contact between epidermal basal cells and fibroblasts and collagen fibers which could result in inappropriate dermal signals reaching the epidermis. In younger embryos the entire epidermis, including the mitotically inactive surface cells, appears to respond to RA, and this could imply an epigenetic modulation of cell phenotype. Finally, after the formation of a stratum corneum in older embryos only the relatively undifferentiated basal layer shows a metaplastic response. indicating that RA could be acting directly on the genome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VITAMIN A
KW  - EPITHELIUM
KW  - TRETINOIN
KW  - CHICKEN embryos
KW  - SKIN
KW  - KERATINIZATION
N1  - Accession Number: 12511354; Peck, Gary L. 1 Elias, Peter M. 2 Wetzel, Bruce 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland U.S.A..  2: Department of Dermatology, University of California, Medical Center, San Francisco, California, U.S.A..; Source Info: Nov77, Vol. 69 Issue 5, p463; Subject Term: VITAMIN A; Subject Term: EPITHELIUM; Subject Term: TRETINOIN; Subject Term: CHICKEN embryos; Subject Term: SKIN; Subject Term: KERATINIZATION; Number of Pages: 14p; Document Type: Article
L3  - 10.1111/1523-1747.ep12511354
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ER  - 

TY  - JOUR
AU  - KOSLOW, STEPHEN H.
AU  - BUTLER, IAN J.
T1  - Biogenic Amine Synthesis Defect in Dihydropteridine Reductase Deficiency.
JO  - Science
JF  - Science
Y1  - 1977/11/04/
VL  - 198
IS  - 4316
M3  - Article
SP  - 522
EP  - 523
SN  - 00368075
AB  - In the enzymatic hydroxylation of aromatic amino acids, tetrahydrobiopterin is the essential cofactor. Regeneration of tetrahydrobiopterin requires dihydropteridine reductase, without which there should be a deficiency of hydroxylated amino acids and their products, biogenic amines. Assay of biopsied brain cortex of a patient with a deficiency of dihydropteridine reductase showed low concentrations of serotonin and dopamine, and this was reflected in the concentrations of their major metabolites measured in cerebrospinalfluidfrom lumbar, ventricular, and subarachnoid spaces. The metabolite concentrations were restored to normal, or above normal, by treatment with specific-amino acids which bypass the metabolic block at the hydroxylation step. It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460689; KOSLOW, STEPHEN H. 1; BUTLER, IAN J. 2; Affiliations: 1: National Institute of Mental Health, Laboratory of Preclinical Pharmacology, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Issue Info: 11/4/1977, Vol. 198 Issue 4316, p522; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - ROWE, WALLACE P.
T1  - Recombinant DNA Guidelines: Scientific and Political Questions.
JO  - Science
JF  - Science
Y1  - 1977/11/11/
VL  - 198
IS  - 4317
M3  - Article
SP  - 563
EP  - 564
SN  - 00368075
N1  - Accession Number: 87460728; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, Maryland 20014; Issue Info: 11/11/1977, Vol. 198 Issue 4317, p563; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Stone, Peter R.
AU  - Lorimer III, Wishard S.
AU  - Kidwell, William R.
T1  - Properties of the Complex between Histone H1 and Poly(ADP-ribose) Synthesised in HeLa Cell Nuclei.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1977/11/15/
VL  - 81
IS  - 1
M3  - Article
SP  - 9
EP  - 18
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Preparations of H1 histone from HeLa cell nuclei incubated with [³H]NA D to permit poly(A DP-ribose) synthesis were electrophoresed on polyacrylamide gels. The incorporated radioactivity migrated as a sharply defined peak in association with a protein band which moved more slowly than HI, the major protein component. The following observations indicate that this complex is composed of two molecules of H1 and a single chain of poly(ADP-ribose) with one detectable covalent linkage of polymer to protein. 1. The [14]arginine/[³H]lysine ratio is identical m H1 histone and in the protein moiety of the complex. 2. Protein is displaced from H1 histone to the complex during poly(ADP-ribose) synthesis. At least 90% of the protein in the complex (stainable protein and labelled protein) is derived from H1. 3. Sedimentation rate studies indicate a molecular weight of the complex about twice that of H1 histone. 4. The average chain length of the polymer is 15 ADP-ribose units and there are 7–8 ADP-ribose units for each molecule of H1 histone in the ‘complex’ 5. Poly(ADP-ribose) glycohydrolase, which hydrolyses the polymer exoglycosidically from the AMP terminus, degrades the complex producing ADP-ribose and mono-ADP-ribosylated H1 histone which co-electrophoreses with unmodified H1. Although only one covalent linkage between protein and polymer has been detected, the ‘complex’ does not dissociate when electrophoresed on dodecylsulfate gels. Nor can the non-covalently linked H histone of the complex readily exchange with free H1. Complex formation does not occur when purified poly(ADP-ribose) and H1 are mixed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTONES
KW  - ADENOSINE diphosphate
KW  - RIBOSE
KW  - HELA cells
KW  - CELL nuclei
KW  - POLYACRYLAMIDE gel electrophoresis
KW  - MOLECULAR weights
N1  - Accession Number: 13489277; Stone, Peter R. 1 Lorimer III, Wishard S. 1 Kidwell, William R. 1; Affiliation:  1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland; Source Info: 11/15/77, Vol. 81 Issue 1, p9; Subject Term: HISTONES; Subject Term: ADENOSINE diphosphate; Subject Term: RIBOSE; Subject Term: HELA cells; Subject Term: CELL nuclei; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: MOLECULAR weights; Number of Pages: 10p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - GRUBBS, CLINTON J.
AU  - MOON, RICHARD C.
AU  - SQUIRE, ROBERT A.
AU  - FARROW, GEORGE M.
AU  - STINSON, SHERMAN F.
AU  - GOODMAN, DAWN G.
AU  - BROWN, CHARLESC.
AU  - SPORN, MICHAEL B.
T1  - 13-cis-Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
JO  - Science
JF  - Science
Y1  - 1977/11/18/
VL  - 198
IS  - 4318
M3  - Article
SP  - 743
EP  - 744
SN  - 00368075
AB  - Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436456; GRUBBS, CLINTON J. 1; MOON, RICHARD C. 1; SQUIRE, ROBERT A. 2; FARROW, GEORGE M. 3; STINSON, SHERMAN F. 4; GOODMAN, DAWN G. 4; BROWN, CHARLESC. 4; SPORN, MICHAEL B. 4; Affiliations: 1: IIT Research Institute, Chicago, Illinois 60616; 2: Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 3: Mayo Clinic, Rochester, Minnesota 55901; 4: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 11/18/1977, Vol. 198 Issue 4318, p743; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - JACQUET, YASUKo F.
AU  - KLEE, WERNER A.
AU  - RICE, KENNER C.
AU  - IIJIMA, IKUO
AU  - MINAMIKAWA, JUNICHI
T1  - Stereospecific and Nonstereospecific Effects of (+)- and (-)- Morphine: Evidence for a New Class of Receptors?
JO  - Science
JF  - Science
Y1  - 1977/11/25/
VL  - 198
IS  - 4319
M3  - Article
SP  - 842
EP  - 845
SN  - 00368075
AB  - The unnatural (+) enantiomer of morphine had minimal activity in three opiate assays in vitro: the rat brain homogenate binding assay, the electrically stimulated guinea pig ileum assay, and the inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cell homogenates. When (+)-morphine was microinjected into the periaqueductal gray (a site known to mediate morphine analgesia) of drugnaive rats, there was only minimal analgesia, but the hyperresponsivity usually observed after microinjection of(-)-morphine occurred. Also, when (+)-morphine was microinjected into the midbrain reticularformation of drug-naive rats, rotation similar to that following microinjection of(-)-morphine occurred. These behaviors were not blocked by naloxone. Significantly, they typically occur in precipitated abstinence in morphine-dependent rats. These observations suggest that there are at least two classes of receptors, one stereospecific and blocked by naloxone and the other only weakly stereospecific and not blocked by naloxone, and that precipitated abstinence may be due, in part, to a selective blockade of receptors of the former class but not of the latter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268553; JACQUET, YASUKo F. 1; KLEE, WERNER A. 2; RICE, KENNER C. 3; IIJIMA, IKUO 3; MINAMIKAWA, JUNICHI 3; Affiliations: 1: New York State Research Institute for Neurochemistry and Drug Addiction, Rockland Psychiatric Institute, Ward's Island 10035; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20014; 3: Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; Issue Info: 11/25/1977, Vol. 198 Issue 4319, p842; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Weisberg, Robert A.
AU  - Adhya, Sankar
T1  - ILLEGITIMATE RECOMBINATION IN BACTERIA AND BACTERIOPHAGE.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1977/12//
VL  - 11
M3  - Article
SP  - 451
EP  - 473
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Presents a study on the illegitimate recombination in bacteria and bacteriophage. Characteristics of transducing phage formation on Phage X; Identification of the deletion mutants in procaryotes; Use of the term illegitimate recombination to describe certain chromosomal rearrangements.
KW  - GENETIC recombination
KW  - BACTERIA
KW  - MUTATION (Biology)
KW  - CHROMOSOMES
N1  - Accession Number: 11911701; Weisberg, Robert A. 1 Adhya, Sankar 2; Affiliation:  1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Halth, Bethesda, Maryland 20014  2: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Source Info: 1977, Vol. 11, p451; Subject Term: GENETIC recombination; Subject Term: BACTERIA; Subject Term: MUTATION (Biology); Subject Term: CHROMOSOMES; Number of Pages: 23p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mock, Michael B.
T1  - Rehabilitation of the elderly cardiac patient hampered by bias.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1977/12//
VL  - 32
IS  - 12
M3  - Article
SP  - 22
EP  - 23
SN  - 0016867X
N1  - Accession Number: 17239146; Mock, Michael B. 1; Source Information: Dec1977, Vol. 32 Issue 12, p22; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 959
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Parrillo, J. E.
AU  - Fauci, A. S.
T1  - Apparent direct cellular cytotoxicity mediated via cytophilic antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1977/12//
VL  - 33
IS  - 6
M3  - Article
SP  - 839
EP  - 850
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Guinea-pigs immunized with chicken red blood cells (CRBC) developed cytotoxic effector cells in peripheral blood, spleen, lymph nodes, bone marrow and peritoneal exudate cells. Although it appeared that direct cytotoxicity was the mechanism of killing in this model, the true mechanism of cytotoxicity was in fact cytophilic antibody firmly bound to the effector cell rendering it specifically cytotoxic to the CRBC targets. Using multiple cell separation procedures, we demonstrated at least three distinct effector cell populations capable of mediating cytotoxicity in this model: a monocyte-macrophage, a non-phagocytic lymphocyte and a neutrophil, all bearing Fc receptors for Ig. Cell free eluates produced from immune effector cells were capable of rendering non-immune cells of all three Fc receptor bearing leucocyte classes cytotoxic. It is noteworthy that several techniques commonly employed to deplete effector cell populations were shown also to remove cytophilic antibody from the surface of these effector cells. If this had not been recognized, the cytophilic antibody component of the system would have been overlooked and erroneous conclusions would have been made as to which cell populations were functioning as effectors. Recent clinical studies have demonstrated a direct cytotoxicity by K lymphocytes—the usual effector cells in antibody dependent cellular cytotoxicity. The present study suggests that in at least some of these cases true direct cytotoxicity may not be the mechanism of killing and that K cells bearing cytophilic antibody may in fact be the effector cell operating by antibody dependent cellular cytotoxicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL-mediated cytotoxicity
KW  - IMMUNOGLOBULINS
KW  - KILLER cells
KW  - LEUCOCYTES
KW  - ERYTHROCYTES
KW  - ANIMAL models in research
N1  - Accession Number: 11215534; Parrillo, J. E. 1 Fauci, A. S. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Dec77, Vol. 33 Issue 6, p839; Subject Term: CELL-mediated cytotoxicity; Subject Term: IMMUNOGLOBULINS; Subject Term: KILLER cells; Subject Term: LEUCOCYTES; Subject Term: ERYTHROCYTES; Subject Term: ANIMAL models in research; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yaoita, Hideo
AU  - Katz, Stephen I.
T1  - CIRCULATING IgA ANTI-BASEMENT MEMBRANE ZONE ANTIBODIES IN DERMATITIS HERPETIFORMIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1977/12//
VL  - 69
IS  - 6
M3  - Article
SP  - 558
EP  - 560
SN  - 0022202X
AB  - Circulating anti-basement membrane zone antibodies of the IgA class were detected in the sera of 2 or 6 dermatitis herpetiformis (DH) patients who had linear in-vivo-bound IgA deposits and in I of 42 DH patients who had granular in vivo-bound IgA deposits. In the former 2 patients the circulating antibodies were localized ultrastructurally to the identical site where the in vivo-bound antibodies were localized and were bound by antigens in either the lamina lucida or the subbasal lamina anchoring fibril area of the basement membrane zone of normal human skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN A
KW  - BASAL lamina
KW  - DERMATITIS herpetiformis
KW  - HUMAN anatomy
KW  - IMMUNOGLOBULINS
KW  - IGA glomerulonephritis
N1  - Accession Number: 12688382; Yaoita, Hideo 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, NIH, Bethesda, Maryland, U.S.A.; Source Info: Dec77, Vol. 69 Issue 6, p558; Subject Term: IMMUNOGLOBULIN A; Subject Term: BASAL lamina; Subject Term: DERMATITIS herpetiformis; Subject Term: HUMAN anatomy; Subject Term: IMMUNOGLOBULINS; Subject Term: IGA glomerulonephritis; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12688382
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gail, Mitchell
AU  - Mantel, Nathan
T1  - Counting the Number of rxc Contingency Tables with Fixed Margins.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1977/12//
VL  - 72
IS  - 360
M3  - Article
SP  - 859
SN  - 01621459
AB  - Exact and approximate methods are given for counting the number of r X c contingency tables with fixed margins. The approximate methods are extended to estimate the number of r X c X s contingency tables with given first-order margins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MARGINS (Futures trading)
KW  - MATHEMATICAL statistics
KW  - STATISTICAL hypothesis testing
KW  - APPROXIMATION theory
KW  - DISTRIBUTION (Probability theory)
KW  - PROBABILITY theory
KW  - CONTINGENCY tables
KW  - INTEGRALS
KW  - CHARACTERISTIC functions
KW  - Enumeration of arrays with liked margins
KW  - Exact conditional tests on contingency tables
KW  - Systems of equations in nonnegative integers.
N1  - Accession Number: 4613926; Gail, Mitchell 1; Mantel, Nathan 2; Affiliations: 1: Medical Statistical Researcher at the Biometry Branch, National Cancer Institute, Landow Building C509, Bethesda, MD 20014.; 2: Research Professor at George Washington University, 7979 Old Georgetown Road,  Bethesda, MD 20014.; Issue Info: Dec77, Vol. 72 Issue 360, p859; Thesaurus Term: MARGINS (Futures trading); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: PROBABILITY theory; Subject Term: CONTINGENCY tables; Subject Term: INTEGRALS; Subject Term: CHARACTERISTIC functions; Author-Supplied Keyword: Enumeration of arrays with liked margins; Author-Supplied Keyword: Exact conditional tests on contingency tables; Author-Supplied Keyword: Systems of equations in nonnegative integers.; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-06293-038
AN  - 2006-06293-038
AU  - Achenbach, Thomas M.
T1  - The Developmental Psychopathology of Adult Psychosis: A Freudian Version.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1977/12//
VL  - 22
IS  - 12
SP  - 922
EP  - 923
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06293-038. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Achenbach, Thomas M.; Laboratory of Developmental Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Child Psychology; Developmental Stages; Psychopathology; Psychosis. Minor Descriptor: Childhood Development. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Freeman, Thomas. Childhood Psychopathology and Adult Psychoses=New York: International Universities Press, 1976. Pp. xii + 293. $16.50; 1976. Page Count: 2. Issue Publication Date: Dec, 1977. 
AB  - Reviews the book, Childhood Psychopathology and Adult Psychoses by Thomas Freeman (see record [rid]1976-12392-000[/rid]). The objective is to demonstrate that the phenomena of adult psychoses can be classified according to their similarities with childhood functioning portrayed in terms of developmental lines and the Developmental Profile. The book is of an unabashedly Freudian lineage. First, it is heavily buttressed with quotations from Freud, both Anna and Sigmund. Second, little heed is paid to relevant nonpsychoanalytic work. Third, it consist exclusively of the author's reports of his own cases. These cases are all adults, and the only data on children are excerpts from psychoanalytic case histories written by others. No data are provided to longitudinally link anything about particular children with later psychosis, even an a correlational fashion, much less to demonstrate causation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - developmental psychopathology
KW  - adult psychosis
KW  - Freudian version
KW  - 1977
KW  - Child Psychology
KW  - Developmental Stages
KW  - Psychopathology
KW  - Psychosis
KW  - Childhood Development
KW  - 1977
U2  - Freeman, Thomas. (1976); Childhood Psychopathology and Adult Psychoses; New York: International Universities Press, 1976. Pp. xii + 293. $16.50
DO  - 10.1037/015631
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06293-038&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 
TY  - JOUR
ID  - 2007-17572-003
AN  - 2007-17572-003
AU  - Gewirtz, Jacob L.
AU  - Boyd, Elizabeth F.
T1  - Does maternal responding imply reduced infant crying? A critique of the 1972 Bell and Ainsworth Report.
JF  - Child Development
JO  - Child Development
JA  - Child Dev
Y1  - 1977/12//
VL  - 48
IS  - 4
SP  - 1200
EP  - 1207
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0009-3920
SN  - 1467-8624
AD  - Gewirtz, Jacob L., NIMH Laboratory of Developmental Psychology, National Institutes of Health, Building 15K, Bethesda, MD, US, 20014
N1  - Accession Number: 2007-17572-003. PMID: 608354 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Gewirtz, Jacob L.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Crying; Individual Differences; Mother Child Relations. Classification: Social Psychology (3000). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Dec, 1977. 
AB  - An examination was made of the published rank correlations (p's) from which Bell and Ainsworth (see record [rid]1973-11043-001[/rid]) concluded that mothers who responded more consistently and promptly to their infants' crying in earlier quarters of the first year had infants who cried less often and long in later quarters of that year. Technical limitations critically restrict interpretations of those p's: (a) intercorrelations were of intrinsically contingent measures; (b) the overlapping, dependent intercorrelations were correlated within and between matrices, with unknown Type I error levels; and (c) there were no statistical controls for likely antecedent and concurrent determinants of the 2 outcome-variable sets. Apart from these technical concerns, Bell and Ainsworth's assumption that maternal responding to crying is the inverse of maternal ignoring of crying and their main conclusions from the between-quarter correlations that depended on it were questioned on the bases of (a) the defined independence between the maternal responding and ignoring variables, (b) the positive within-quarter pattern of correlation between them, and (c) the failure to present between-quarter correlations between maternal responding and infant crying. At the same time, Bell and Ainsworth's data were remote from the level of detail required by an operant-learning account (to which, nevertheless, many have referred them). Under such a learning account, various outcomes would be plausible, including the outcome Bell and Ainsworth emphasized. It was concluded that Bell and Ainsworth's main conclusion, that maternal responding implied a reduction in infant crying, was not supported by their data. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - maternal response consistency & promptness
KW  - decline frequency & duration of infant crying
KW  - infant-mother pairs
KW  - 1977
KW  - Crying
KW  - Individual Differences
KW  - Mother Child Relations
KW  - 1977
DO  - 10.2307/1128476
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17572-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2007-17572-005
AN  - 2007-17572-005
AU  - Gewirtz, Jacob L.
AU  - Boyd, Elizabeth F.
T1  - In reply to the rejoinder to our critique of the 1972 Bell and Ainsworth Report.
JF  - Child Development
JO  - Child Development
JA  - Child Dev
Y1  - 1977/12//
VL  - 48
IS  - 4
SP  - 1217
EP  - 1218
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0009-3920
SN  - 1467-8624
AD  - Gewirtz, Jacob L., NIMH Laboratory of Developmental Psychology, National Institutes of Health, Building 15K, Bethesda, MD, US, 20014
N1  - Accession Number: 2007-17572-005. Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Gewirtz, Jacob L.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Crying; Individual Differences; Mother Child Relations. Classification: Social Psychology (3000). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Dec, 1977. 
AB  - Reply to the rejoinder by Ainsworth and Bell (see record [rid]2007-17572-004[/rid]) to the critique of Gewirtz and Boyd (see record [rid]2007-17572-003[/rid]) on the original article by Bell and Ainsworth (see record [rid]1973-11043-001[/rid]) about infant crying and maternal responsiveness. Ainsworth and Bell have assumed mistakenly that we intended to denigrate their paradigm or enter a cross-paradigm controversy, despite our circumscribed objectives as stated at the outset of our critique. Bell and Ainsworth's primary conclusion was based on the analysis and interpretation of the relationship between measures of maternal unresponsiveness and infant crying. Therefore our critique focuses on this analysis and interpretation. Our concern with their use of the measure of maternal unresponsiveness was not that it was inherently faulty and should not have been used. Our concern with Bell and Ainsworth's statistical analysis was not that they used non-parametric statistics instead of cross-lag procedures. It was that they neither acknowledged that statistical controls for apparent artifacts were required nor qualified the interpretations of their analyses for the absence of those controls. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - maternal response consistency & promptness
KW  - frequency & duration of infant crying
KW  - infant-mother pairs
KW  - 1977
KW  - Crying
KW  - Individual Differences
KW  - Mother Child Relations
KW  - 1977
DO  - 10.2307/1128478
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17572-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2007-17572-032
AN  - 2007-17572-032
AU  - Barrett, David E.
T1  - Reflection-impulsivity as a predictor of children's academic achievement.
JF  - Child Development
JO  - Child Development
JA  - Child Dev
Y1  - 1977/12//
VL  - 48
IS  - 4
SP  - 1443
EP  - 1447
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0009-3920
SN  - 1467-8624
AD  - Barrett, David E., Laboratory of Developmental Psychology, National Institute of Mental Health, Building 15K, 9000 Rockville Pike, Bethesda, MD, US, 20014
N1  - Accession Number: 2007-17572-032. PMID: 608365 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Barrett, David E.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Academic Achievement; Elementary School Students; Impulsiveness; Reflectiveness. Classification: Academic Learning & Achievement (3550). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Tests & Measures: Comprehensive Tests of Basic Skills; Matching Familiar Figures Test DOI: 10.1037/t09907-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Dec, 1977. 
AB  - To examine the implications of differences in reflection-impulsivity for later academic achievement, 70 children were administered the Matching Familiar Figures test (MFF) in grade 4 and the Comprehensive Tests of Basic Skills (CTBS) in grades 4, 5, and 6. Children identified as reflective based on grade 4 MFF performance scored significantly higher on the CTBS achievement battery at all grade levels than those classified as impulsive. However, the 2 groups did not differ on the grade 5 or grade 6 achievement measures when scores were adjusted for initial differences in grade 4 CTBS. Similarly, while each of the continuous variables MFF error score and MFF response latency was significantly predictive of grade 5 and grade 6 achievement test scores, neither of the MFF variables significantly improved the prediction of academic performance when current level of achievement was statistically accounted for. Sex differences in the relations between the MFF variables and the achievement measures were identified; MFF error score was more strongly related to later academic achievement for boys than for girls, while MFF response latency was a better predictor of academic achievement for girls than for boys. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - academic achievement
KW  - reflection
KW  - impulsivity
KW  - children
KW  - 1977
KW  - Academic Achievement
KW  - Elementary School Students
KW  - Impulsiveness
KW  - Reflectiveness
KW  - 1977
DO  - 10.2307/1128505
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17572-032&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2007-17572-061
AN  - 2007-17572-061
AU  - Anderson, Barbara J.
AU  - Vietze, Peter
AU  - Dokecki, Paul R.
T1  - Reciprocity in vocal interactions of mothers and infants.
JF  - Child Development
JO  - Child Development
JA  - Child Dev
Y1  - 1977/12//
VL  - 48
IS  - 4
SP  - 1676
EP  - 1681
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0009-3920
SN  - 1467-8624
AD  - Anderson, Barbara J., National Institute of Child Health and Human Development, National Institutes of Health, Auburn Building, Room 220, Bethesda, MD, US, 20014
N1  - Accession Number: 2007-17572-061. PMID: 608379 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Anderson, Barbara J.; Social and Behavioral Science Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Biennial Meeting of the Society for Research in Child Development, Apr, 1975, Denver, CO, US. Grant Information: Vietze, Peter. Conference Note: Portions of this paper were presented at the aforementioned conference. Major Descriptor: Mother Child Relations; Reciprocity; Vocalization. Minor Descriptor: Mothers. Classification: Childrearing & Child Care (2956); Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 1977. 
AB  - Social responses of 24 mothers and 3-month-old infants were continuously observed and coded in the home to examine reciprocal influences in early vocal interactions. One of 4 dyadic vocal states (simultaneous vocalization, mother vocalizing alone, infant vocalizing alone, mutual silence) was assigned to each consecutive 1-sec interval of the 90-min observational records. The sequence of dyadic vocal states was represented by a first-order transition probability matrix. Transitions between states involving maternal and infant vocal onsets and offsets were analyzed. Results indicated that vocal onsets for both mother and infant were more likely when the other dyad member was vocalizing. There was no evidence of reciprocal influences for vocal offsets. It is suggested that differentiating response onset and offset is necessary for understanding vocal reciprocity in mother-infant interaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - reciprocity
KW  - vocal interactions
KW  - mother infant interaction
KW  - 1977
KW  - Mother Child Relations
KW  - Reciprocity
KW  - Vocalization
KW  - Mothers
KW  - 1977
U1  - Sponsor: National Institute of Education. Grant: NE-C-00-3-0260. Other Details: Research Contract. Recipients: Vietze, Peter
DO  - 10.2307/1128534
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17572-061&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - TAN, HENRY K.
AU  - ANDERSEN, JUDITH C.
T1  - Human Factor VIII: Morphometric Analysis of Purified Material in Solution.
JO  - Science
JF  - Science
Y1  - 1977/12/02/
VL  - 198
IS  - 4320
M3  - Article
SP  - 932
EP  - 934
SN  - 00368075
AB  - Study of purified human factor VIII in buffer by freeze-etch electron microscopy reveals rounded, rod-shaped particles measuring 22 by 42 nanometers. When thrombin was added to purified normal factor VIII, there was a rapid loss of rod-shaped particles during the first 15 minutes of incubation at 37°C. Purified plasma from two patients with severe hemophilia contained spherical particles measuring 10 to 50 nanometers in diameter, with no evidence of significant numbers of rod-shapedforms. Negatively stained and unstained air-dried samples of factor VIII corroborate the relative shape and size differences between normal and hemophiliac material. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436516; TAN, HENRY K. 1; ANDERSEN, JUDITH C. 1; Affiliations: 1: Hematology Section, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/2/1977, Vol. 198 Issue 4320, p932; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - COLE, ROGER M.
AU  - MITCHELL, WILLIAM O.
AU  - GARON, CLAUDE F.
T1  - Spiroplasmavirus citri 3: Propagation, Purification, Proteins, and Nucleic Acid.
JO  - Science
JF  - Science
Y1  - 1977/12/23/
VL  - 198
IS  - 4323
M3  - Article
SP  - 1262
EP  - 1263
SN  - 00368075
AB  - SVC3 is a short-tailed polyhedral virus particle morphologically detectable in many spiroplasmas. It was isolated from two different spiroplasmas (Spiroplasma citri and the suckling mouse cataract agent) by infecting lawns and broth culture of another strain of Spiroplasmavirus citri. Virions from either donor strain had a buoyant density of 1.26 grams per cubic centimeter (metrizamide) or 1.45 grams per cubic centimeter (cesium chloride), and contained five proteins and linear double-stranded DNA with a molecular weight of 14 × 106. Other spiroplasmaviruses have not been propagated, and the molecular weights of doublestranded DNA from other mycoplasma (Acholeplasma) viruses are unknown. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519203; COLE, ROGER M. 1; MITCHELL, WILLIAM O. 1; GARON, CLAUDE F. 1; Affiliations: 1: Laboratory of Streptococcal Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 12/23/1977, Vol. 198 Issue 4323, p1262; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GULATI, JAGDISH
AU  - PALMER, L. G.
T1  - Potassium Accumulation in Frog Muscle: The Association-Induction Hypothesis versus the Membrane Theory.
JO  - Science
JF  - Science
Y1  - 1977/12/23/
VL  - 198
IS  - 4323
M3  - Article
SP  - 1283
EP  - 1284
SN  - 00368075
N1  - Accession Number: 87519211; GULATI, JAGDISH 1; PALMER, L. G. 2; Affiliations: 1: Library of Physical Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Physiology, University of Pennsylvania, Philadelphia 19174; Issue Info: 12/23/1977, Vol. 198 Issue 4323, p1283; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-08720-000
AN  - 9999-08720-000
AU  - Pearlin, Leonard I.
AU  - Schooler, Carmi
T1  - Coping Interview Schedule
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1978///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-08720-000. Partial author list: First Author & Affiliation: Pearlin, Leonard I.; National Institute of Mental Health. Release Date: 20120312. Correction Date: 20151109. Instrument Type: Interview Schedule/Guide. Test Format: The measures are based on adjective check-lists. There were four intensity categories from which subjects chose their response to each adjective.. Language: English. Constructs: Coping Strategies; Life Strains; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). 
AB  - Purpose: This interview measures coping strategies in the general population in four areas: marriage, parenting, household economics, and work.
AB  - Description: The Coping Interview Schedule (Pearlin & Schooler, 1978) was part of a larger investigation into the social origins of personal stress; a sample of 2300 18-65 year old people representative of the population in the Census-defined urbanized area of Chicago were interviewed. The schedule was designed to yield several distinct types of information. First, it asks people about potential life strains—that is, conflicts, frustrations, and threats—that earlier exploratory interviews had revealed to be commonly experienced in major social role areas. Second, the interview includes a number of questions about the coping repertoires people employ in dealing with the strains they experience in these roles. And third, it inquires into the emotional stresses that people feel and the extent to which they experience symptoms of depression and anxiety. The strains that are included foe study here were identified from themes that surfaced repeatedly during relatively unstructured interviews with over 100 subjects. Standardized questions about these strains were gradually developed, tested, and included in the final interview schedule. Eleven factors were delineated, three in marriage, three in the parental area, one in household economics, and four in occupation. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Coping Interview Schedule
KW  - Interviews
KW  - Life Strains
KW  - Emotional Stress
KW  - General Population Surveys
KW  - Marriage
KW  - Parenting
KW  - Household Economics
KW  - Coping Efficacy
KW  - Coping Mechanisms
KW  - Job Stress
U5  - Coping Interview Schedule [Test Development]The structure of coping. (AN: 1979-06036-001 from PsycINFO) Pearlin, Leonard I.; Schooler, Carmi; Mar, 1978. Source: Journal of Health and Social Behavior. 19(1), American Sociological Assn, US; Mar, 1978; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Location: United States; Sample: People Representative of the Population in the Census-Defined Urbanized Area of Chicago Keywords: Coping Interview Schedule; Interviews; Life Strains; Emotional Stress; General Population Surveys; Marriage; Parenting; Household Economics; Coping Efficacy; Coping Mechanisms; Job Stress; Subjects: Coping Behavior; Factor Structure; Financial Strain; Interviews; Marital Conflict; Occupational Stress; Parenting; Stress; Surveys;
DO  - 10.1037/t08720-000
L3  - Partial; Full text; 999908720_partial_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-09180-000
AN  - 9999-09180-000
AU  - Edelbrock, Craig
AU  - Sugawara, Alan I.
T1  - Sex Role Learning Index
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1978///
AD  - Edelbrock, Craig, National Institute of Mental Health, Laboratory of Developmental Psychology, Building 15K, Bethesda, Maryland, United States, 20014
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-09180-000. Acronyms: SERLI. Partial author list: First Author & Affiliation: Edelbrock, Craig; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20120312. Correction Date: 20160613. Instrument Type: Index/Indicator. Test Format: Participants sort the drawings according to whether they are appropriate for boys or girls.. Language: English. Constructs: Sex Role Stereotypes; Sex Roles; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Sex Role Learning Index is to compare children's preferences to both sex role stereotypes and each child's conception of what is sex appropriate.
AB  - Description: The Sex Role Learning Index (SERLI; Edelbrock & Sugawara, 1978) is a picture-choice instrument designed to compare preschool children's preferences to both sex role stereotypes and each child's conception of what is sex appropriate. The goals in the development of the SERLI were to (a) compare children's preferences to both sex role stereotypes and each child's conception of what is sex appropriate, (b) distinguish between child and adult figures participating in the activities and roles depicted in the test items, and (c) use a probabilistic scoring system based on the order of the child's choices. The SERLI was designed to measure three concepts: (1) Sex role discrimination (SRD), (2) Sex role preference (SRP), and (3) Sex role confirmation (SRC). Separate SERLI forms were developed for boys and girls. Each form contains 30 black-and-white line drawings, organized into three sections: (a) the child figures section, (b) the adult figures section, and (c) the objects section. The items in the two forms are identical, except that the boys' form depicts only male figures engaged in the various activities and roles, while the girls' form depicts female figures. The child and adult figures sections contain 10 items each, half stereotyped as masculine and half as feminine. The Objects section contains 20 drawings of objects representing the activities and roles in the child and adult figures sections. The SERLI was designed to allow the individual child the opportunity to specify any particular item as being appropriate for both sexes and to score children's preferences according to both the child's point of view and cultural sex role stereotypes. The SERLI uses a simple Q-sort technique to gain a free- and forced-choice classification of the objects into sex role categories. The free-choice classification is used to score SRC, and the forced-choice classification is used to measure SRD. As part of the test development process, several studies were undertaken to assess the adequacy of the SERLI as an alternative conceptual and methodological approach to assessing sex role acquisition in preschool-aged children, overcoming some of the conceptual and methodological problems of previous instruments. Reliability estimates were also determined. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Child Attitudes
KW  - Sex Role Acquisition
KW  - Sex Role Confirmation Scale
KW  - Sex Role Discrimination Scale
KW  - Sex Role Learning Index
KW  - Sex Role Preference Scale
KW  - Sex Role Stereotypes
KW  - Test Construction
KW  - Young Children
KW  - Psychometric Properties
KW  - Sex Role Preferences
U5  - Sex Role Learning Index (SERLI) [Test Development]Acquisition of sex-typed preferences in preschool-aged children. (AN: 1979-28363-001 from PsycINFO) Edelbrock, Craig S.; Sugawara, Alan I.; Nov, 1978. Source: Developmental Psychology. 14(6), American Psychological Association, US; Nov, 1978; Administration: Paper Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Sample: Children Aged 35-65 Months from Preschools and Daycare Centers Keywords: Child Attitudes; Sex Role Acquisition; Sex Role Confirmation Scale; Sex Role Discrimination Scale; Sex Role Learning Index; Sex Role Preference Scale; Sex Role Stereotypes; Test Construction; Young Children; Psychometric Properties; Subjects: Attitude Measures; Child Attitudes; Cognitive Discrimination; Early Childhood Development; Preference Measures; Preferences; Q-Sort; Sex Role Attitudes; Sex Roles; Stereotyped Attitudes; Test Construction; Test Reliability; Test Validity;
U5  - Sex Role Learning Index (SERLI) [Test Use]Sex-role preference in Australian aboriginal and White children. (AN: 1983-03186-001 from PsycINFO) Callan, Victor J.; Liddy, Linda; Jun, 1982. Source: The Journal of Social Psychology. 117(1), Heldref Publications, US; Jun, 1982; Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Ethnicity: Aboriginal and White Students; Location: Australia; Sample: Preschool and Kindergarten Students Aged 3-5 Keywords: Child Attitudes; Sex Role Learning Index; Sex Role Preferences; Sex Role Stereotypes; Young Children; Subjects: Attitude Measures; Child Attitudes; Early Childhood Development; Preference Measures; Preferences; Sex Role Attitudes; Sex Roles; Stereotyped Attitudes;
DO  - 10.1037/t09180-000
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-10996-000
AN  - 9999-10996-000
AU  - Aaronson, May
AU  - Phillips, Julie
AU  - Bertolucci, Darryl
AU  - Aaronson, Doris
T1  - Preschool Preposition Test
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1978///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-10996-000. Acronyms: PPT. Partial author list: First Author & Affiliation: Aaronson, May; Department of Health, Education, & Welfare, National Institute of Mental Health, Rockville, Maryland, United States. Release Date: 20120507. Correction Date: 20151109. Instrument Type: Test. Test Format: To administer the test, the examiner hands the child a red half-ball that is covered with a magnetic material. on the flat side. The examiner directs the child to make placements with the ball onto an illustrated metal board- placed upright in. front of him. The board· is painted with a picture of a red boy facing a green car on a yellow background. The examiner reads aloud the 23 items in turn, each containing a preposition or prepositional phrase. In response, the child places the magnetized ball onto the board, where it adheres. The examiner then marks the child's placement with an X on a Picture Score Sheet.. Language: English. Constructs: Verbal Comprehension; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). 
N2  - Administration Method: Paper
AB  - Purpose: The PPT is a receptive language test which examines the comprehension of verbal directions using spatial prepositions or prepositional phrases together·with objects.
AB  - Description: This historic document is included through collaboration with the University of Akron, Archives of the History of American Psychology, University Libraries. The Preschool Preposition Test (PPT) is a developmental screening test for Head Start. It was used to identify children needing early scholastic assistance. The PPT is a quick, game-like, receptive language test for children ages 3 to 5, with validity and reliability data involving over 1400 children. Its long range predictive power is supported by impressive correlations between Head Start PPT scores and scores of mental ability and scholastic achievement five years later. Data point to a linkage between PPT scores and maternal nurturant and verbal behavior with the child. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Head Start Screening
KW  - Preschool Preposition Test
KW  - Receptive Language
KW  - Verbal  Comprehension
U5  - Preschool Preposition Test (PPT) [Test Primary Data] Administration: Paper Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Sample:  Preschoolers Keywords: Head Start Screening; Preschool Preposition Test; Receptive Language; Verbal  Comprehension; Subjects: Project Head Start; Screening Tests; Verbal Comprehension;
DO  - 10.1037/t10996-000
L3  - Full; Full text; 999910996_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-10996-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-13885-000
AN  - 9999-13885-000
AU  - Pearlin, Leonard I.
AU  - Schooler, Carmi
T1  - Pearlin's Self-Denigration Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1978///
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-13885-000. Partial author list: First Author & Affiliation: Pearlin, Leonard I.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20120813. Correction Date: 20160808. Instrument Type: Rating Scale. Test Format: Respondents are asked how strongly they agree or disagree with measure items.. Language: English. Constructs: Self Denigration; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the scale is to assess the extent to which one holds negative attitudes toward oneself.
AB  - Description: Pearlin's Self-Denigration Scale (Pearlin & Schooler, 1978) is a 4-item measure that assesses the extent to which one holds negative attitudes toward oneself. Participants are asked 'How strongly do you agree or disagree that: (1) I certainly feel useless at times; (2) At times I think I am no good at all; (3) I wish I could have more respect for myself ; (4) All in all, I am inclined to feel that I'm a failure.' It was developed as part of a study exploring the effectiveness of coping strategies in various settings. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Pearlin's Self-Denigration Scale
KW  - Test Development
U5  - Pearlin's Self-Denigration Scale [Test Development]The structure of coping. (AN: 1979-06036-001 from PsycINFO) Pearlin, Leonard I.; Schooler, Carmi; Mar, 1978. Source: Journal of Health and Social Behavior. 19(1), American Sociological Assn, US; Mar, 1978; Administration: Paper Population: Human; Male; Female; Sample: Various Individuals Keywords: Pearlin's Self-Denigration Scale; Test Development; Subjects: Rating Scales; Self-Defeating Behavior; Test Construction;
DO  - 10.1037/t13885-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-13885-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - GEN
AU  - Schneider, John H
T1  - Cancergrams: a large-scale system for selective dissemination of information to cancer researchers
JO  - Cancergrams: a large-scale system for selective dissemination of information to cancer researchers
JF  - Cancergrams: a large-scale system for selective dissemination of information to cancer researchers
Y1  - 1978///
M3  - Book
AB  - One of the services of the international cancer research data bank (icrdb) program is a large-scale system for the selective dissemination of information to groups fo cancer researchers. This system is based on the production of 60 different current awareness bulletins, each covering a major cancer research topic. These bulletins, called cancergrams, are mailed each month to researchers working in the area covered by the corresponding cancergram
N1  - Accession Number: ISTA1500389; Schneider, John H 1; Affiliations: 1 : Office Of International Affairs, National Cancer Institute, Bethesda, Md;  Source Info: 1978; Note: Update Code: 1500; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Parrillo, J. E.
AU  - Fauci, A. S.
T1  - Mechanisms of corticosteroid action on lymphocyte subpopulations.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/01//
VL  - 31
IS  - 1
M3  - Article
SP  - 116
EP  - 125
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The present study investigated the effect of dexamethasone (DEX) administration on different populations of mononuclear cells and neutrophils mediating antibody-dependent cellular cytotoxicity (ADCC) against different target cells. Mononuclear cells (lymphocytes and monocytes) and neutrophils were obtained from twenty-seven normal volunteers at 0, 4, 24 and 48 hr after oral administration of 21 mg of DEX. ADCC was determined utilizing the following targets: human red blood cells (HRBC), Chang liver cells (Ch) and human heart cells (HHC). The predominant mononuclear effector in HRBC killing was shown to be a monocyte and in Ch and HHC killing, a K cell. As previously shown, DEX produced a profound monocytopenia and lymphocytopenia at 4 hr with a return of lymphocyte counts to normal and monocyte counts to supra-normal at 24 hr. At the point of maximal mono-cytopenia, monocyte-mediated HRBC killing decreased from a geometric mean of 14 to 4 lytic units per 108 effector cells (P<0-05) and rebounded at 24 hr to a mean of 39 lytic units (P<0.02) with the rebound monocytosis. At the point of absolute lymphopenia (4 hr), there was a relative enrichment in the proportion of lymphocytes bearing an Fc receptor (K cells, P<0.01). Concomitant with this was an increase in ADCC against Ch and HHC from geometric means of 1121 to 7172 lytic units and 939 to 7354 lytic units (P<0.001) respectively. Thus, a major action of DEX administration on mononuclear ADCC was to differentially enrich or deplete different effector cells to and from the circulation, causing changes in cytotoxicity. Since the cytotoxicity paralleled the proportion of effector cells, the cells remaining in the circulation following DEX administration retained normal antibody-dependent cytotoxic capabilities. Neutrophil-mediated ADCC against HRBC significantly increased at 4 hr from a geometric mean of 3785 to 20142 lytic units (P<0.02) concomitant with the blood neutrophilia and remained elevated for 72 hr. Neutrophil ADCC against Ch and HHC was minimal and was not affected by DEX administration. This study demonstrates differential effects of corticosteroids on antibody-dependent cell-mediated cytotoxicity, reflecting changes in proportion of circulating effector cell populations. These changes depend on (a) the target cell employed, (b) the effector cell mediating cytotoxicity and (c) the duration of time since the last dose of corticosteroid. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - CELL proliferation
KW  - CELL receptors
KW  - ADRENOCORTICAL hormones
KW  - CELL death
KW  - LIVER cells
N1  - Accession Number: 16253620; Parrillo, J. E. 1,2,3 Fauci, A. S. 1,2,3; Affiliation:  1: Laboratory of Clinical Investigation, Bethesda, Maryland, U.S.A..  2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A..  3: National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jan1978, Vol. 31 Issue 1, p116; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Subject Term: CELL receptors; Subject Term: ADRENOCORTICAL hormones; Subject Term: CELL death; Subject Term: LIVER cells; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Giambra, Leonard M.
AU  - Traynor, Thomas D.
T1  - DEPRESSION AND DAYDREAMING: AN ANALYSIS BASED ON SELF-RATINGS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1978/01//
VL  - 34
IS  - 1
M3  - Article
SP  - 14
EP  - 25
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article presents information on depression and daydreaming. Daydreaming and related mental activity were determined from responses to a retrospective questionnaire developed by previous studies. Each Irnaginal Processes Inventory (IPI) item consists of five options that represent points on a continuum that implies frequency or quantity. A total of 28 scales are determined from nonover- lapping items depression, anxiety, poor interpersonal relationships, and alcoholism. Thus it appears that daydreaming is related to affect and that the affect associated with depression may be a potent determinant of the daydreaming. This study was a further investigation of the relationship between daydreaming and depression.
KW  - MENTAL depression
KW  - STRESS (Psychology)
KW  - MENTAL health
KW  - SELF-evaluation
KW  - DREAMS
KW  - ALCOHOLICS
KW  - INTERPERSONAL relations
N1  - Accession Number: 15828575; Giambra, Leonard M. 1 Traynor, Thomas D. 2; Affiliation:  1: National Institute on Aging.  2: Miami University.; Source Info: Jan1978, Vol. 34 Issue 1, p14; Subject Term: MENTAL depression; Subject Term: STRESS (Psychology); Subject Term: MENTAL health; Subject Term: SELF-evaluation; Subject Term: DREAMS; Subject Term: ALCOHOLICS; Subject Term: INTERPERSONAL relations; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kapur, Malavika
T1  - A SHORT SCREENING BATTERY OF TESTS TO DETECT ORGANIC BRAIN DYSFUNCTION.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1978/01//
VL  - 34
IS  - 1
M3  - Article
SP  - 104
EP  - 111
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article presents information on a short screening device to measure organic brain dysfunction suitable for literate and non-literate populations. It was the aim of this study to construct a screening battery of psychological tests to detect in a short time and without sophisticated equipment the presence of organic brain dysfunction among literate and nonliterate Ss. More specifically, the aims of the study were to examine whether certain selected psychological tests could discriminate between a matched group of those who suffer organic brain dysfunction and normals, to examine whether these tests could be combined through a statistical procedure in the form of a battery that would have higher predictive ability and lower misclassification rate than the individual tests.
KW  - PSYCHOLOGICAL tests
KW  - PSYCHOLOGY
KW  - DIAGNOSIS
KW  - CLINICAL psychology
KW  - HUMAN biology
KW  - MEDICAL equipment
N1  - Accession Number: 15828597; Kapur, Malavika 1; Affiliation:  1: National Institute of Mental Health and Neuro Sciences, Bangalore, India.; Source Info: Jan1978, Vol. 34 Issue 1, p104; Subject Term: PSYCHOLOGICAL tests; Subject Term: PSYCHOLOGY; Subject Term: DIAGNOSIS; Subject Term: CLINICAL psychology; Subject Term: HUMAN biology; Subject Term: MEDICAL equipment; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Edelson, Richard
AU  - Finkelman, Fred
AU  - Steinberg, Alfred
AU  - Ahmed, Aftab
AU  - Broder, Samuel
AU  - Strong, Michael
AU  - Green, Ira
T1  - REACTIVITY OF LUPUS ERYTHEMATOSUS ANTIBODIES WITH LEUKEMIC HELPER T CELLS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/01//
VL  - 70
IS  - 1
M3  - Article
SP  - 42
EP  - 44
SN  - 0022202X
AB  - Immunoabsorbent columns, containing membrane fragments of either leukemic "helper" T cells or B cell lymphoblasts, were used to isolate and study antilymphocyte antibodies from plasmas of 2 patients with systemic lupus erythematosus (SLE). Both plasmas contained IgG which bound to and could be eluted from the "helper" T cell column. These antibodies significantly inhibited normal lymphocyte proliferative responses to microbial and histocompatibility antigens. The findings indicate that these SLE plasmas contain immunoglobulins of the IgG class which react with leukemic "helper" T cells and inhibit normal effector T cell function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LUPUS erythematosus
KW  - SKIN diseases
KW  - IMMUNOGLOBULINS
KW  - LEUKEMIC reticuloendotheliosis
KW  - T cells
KW  - B cells
N1  - Accession Number: 12543469; Edelson, Richard 1,2,3,4,5 Finkelman, Fred 1,2,3,4,5 Steinberg, Alfred 1,2,3,4,5 Ahmed, Aftab 1,2,3,4,5 Broder, Samuel Strong, Michael 1,2,3,4,5 Green, Ira 1,2,3,4,5; Affiliation:  1: The Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, New York  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.  3: National Institute of Arthritis, Metabloic and Digestive Diseases, National Cancer, Bethesda, Maryland, U.S.A.  4: Institute, N.I.H., Bethesda, Maryland, U.S.A.  5: Naval Medical Research Institute, Bethesda, Maryland, U.S.A.; Source Info: Jan1978, Vol. 70 Issue 1, p42; Subject Term: LUPUS erythematosus; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: LEUKEMIC reticuloendotheliosis; Subject Term: T cells; Subject Term: B cells; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543469
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-42051-004
AN  - 2013-42051-004
AU  - Hersh, S. P.
T1  - Sweden's approach to health screening for preschool children.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1978/01//
VL  - 48
IS  - 1
SP  - 33
EP  - 39
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Hersh, S. P., National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20852
N1  - Accession Number: 2013-42051-004. PMID: 623220 Partial author list: First Author & Affiliation: Hersh, S. P.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Health Care Services; Health Screening; Program Development. Minor Descriptor: Preschool Students. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Sweden. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). References Available: Y. Page Count: 7. Issue Publication Date: Jan, 1978. 
AB  - The findings of a recent study of the approach taken by Sweden to a perceived problem in that nation’s child health care system are reviewed. The Swedish experience is discussed in terms of its application to the United States, with particular reference to EPSDT and the newly proposed Child Health Assessment Program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - health screening
KW  - preschool children
KW  - child health care system
KW  - health assessment programs
KW  - 1978
KW  - Child Care
KW  - Health Care Services
KW  - Health Screening
KW  - Program Development
KW  - Preschool Students
KW  - 1978
DO  - 10.1111/j.1939-0025.1978.tb01287.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42051-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09710-001
AN  - 2005-09710-001
AU  - Buchsbaum, Monte S.
AU  - Haier, Richard J.
T1  - Biological Homogeneity, Symptom Heterogeneity, and the Diagnosis of Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1978///
VL  - 4
IS  - 4
SP  - 473
EP  - 475
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Buchsbaum, Monte S., NIMH, Bldg. 10, Rm. 2N212, 9000 Rockville Pike, Bethesda, MD, US, 20014
N1  - Accession Number: 2005-09710-001. PMID: 734358 Partial author list: First Author & Affiliation: Buchsbaum, Monte S.; Laboratory of Psychology and Psychopathology, Division of Clinical and Behavioral Research, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Biopsychosocial Approach; Psychiatric Symptoms; Psychodiagnosis; Schizophrenia. Minor Descriptor: Affective Disorders; Positive and Negative Symptoms. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1978. 
AB  - Recent research progress warrants the use of biological variables for developing psychiatric diagnostic systems just as biological measures are used in other branches of medicine. In fact, psychiatrists already bow to internal medicine when biological indicators of tertiary syphilis, lupus, or hypothyroidism are present. Even in areas not yet ceded to infectious disease, immunology or endocrinology, biological factors are used to make diagnoses. Though unsanctioned, the use of lithium carbonate response in differentially diagnosing affective disorder and schizophrenia is not uncommon. In this case, the clinical psychiatrist may be conceptually step ahead of the biological researcher, because he has identified a diagnostic group homogeneous with respect to a salient biological feature and is willing to ignore the symptom heterogeneity. While he might write 'affective disorder' in the chart, the implied diagnosis is really 'lithium sensitive behavioral syndrome.' As classification is the first step in science, diagnosis is the most fundamental problem in psychiatry. Biological researchers have an opportunity to develop new modes of psychiatric diagnoses that go beyond the traditional categories and draw upon new knowledge from the neurosciences. Today's biological researcher searching for a laboratory test for 'schizophrenia' is not going to find it. Multiple etiologies, false negative symptom elicitation, false positive symptom expression, and the lack of external validating criteria all prevent the identification of a homogeneous schizophrenic group for study. A laboratory test for 'dopamine disease,' however, is a possibility with current technology. Whether dopamine disease or other biologically based diagnoses are clinically useful diagnoses needs to be determined with new research strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - symptom heterogeneity
KW  - affective disorders
KW  - biological homogeneity
KW  - psychiatric diagnostic systems
KW  - symptom expression
KW  - 1978
KW  - Biopsychosocial Approach
KW  - Psychiatric Symptoms
KW  - Psychodiagnosis
KW  - Schizophrenia
KW  - Affective Disorders
KW  - Positive and Negative Symptoms
KW  - 1978
DO  - 10.1093/schbul/4.4.473
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rechler, Mathew M.
AU  - Frylund, Linda
AU  - Nissley, S. Peter
AU  - Hall, Kerstin
AU  - Podskalny, Judith M.
AU  - Skottner, Anna
AU  - Moses, Alan C.
T1  - Purified Human Somatomedin A and Rat Multiplication Stimulating Activity.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/01/02/
VL  - 82
IS  - 1
M3  - Article
SP  - 5
EP  - 12
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have compared the mitogenic activity and reactivity in receptor binding assays of somatomedin A and multiplication-stimulating activity (MSA), two acid-soluble polypeptides of molecular weight 7-10 000 that possess weak intrinsic insulin-like metabolic activity. Somatomedin A was purified to homogeneity from human plasma, and MSA was purified to homogeneity from the conditioned culture media of a cell line, BRL 3A, derived from rat liver. The two peptides stimulated DNA synthesis in chick embryo fibroblasts 3-4-fold and have superimposable doseresponse curves. Addition of either peptide to chick embryo fibroblasts plated in serum-free medium increased the cell number by 150% in 4 days, compared with an increase of 25% in control cultures receiving no additions. The two peptides also stimulated DNA synthesis in human fibroblasts in culture 3-4-fold. Specific receptors for MSA and/or somatomedin A could be demonstrated in intact cells or membranes from chick embryo fibroblasts, human fibroblasts, human placenta, rat liver, and the BRL 3A2 cell line, a subclone of the line that produces MSA. Unlabeled MSA and somatomedin A inhibited the binding of 125I-labeled MSA and 125I-labeled somatomedin A to each of these receptors with comparable potency. In chick embryo fibroblasts, human fibroblasts, and human placental membranes, the binding of both radioactive ligands also was inhibited by insulin, consistent with the interpretation that 125I-labeled MSA and 125I-labeled somatomedin A were binding to the same receptor. By contrast, in the BRL 3A2 cell line, insulin inhibited the binding of 125I-labeled somatomedin A, but not the binding of 125I-labeled MSA, suggesting that the two labeled peptides were binding to different receptors in this cell line. Moreover, 125I-labeled MSA, but not 125I-labeled somatomedin A, bound specifically to rat liver plasma membranes. These results indicate that human somatomedin A and rat MSA are closely related, but not identical, peptides. They have similar mitogenic activity for cultured fibroblasts, and cross-react with specific cell receptors with comparable potency. The two radioactively labeled peptides, however, can be distinguished by certain cell surface receptors for somatomedin-like peptides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOMATOMEDIN
KW  - SOMATOTROPIN
KW  - PEPTIDES
KW  - GROWTH factors
KW  - PROTEINS
KW  - BIOCHEMISTRY
N1  - Accession Number: 13602365; Rechler, Mathew M. 1 Frylund, Linda 1 Nissley, S. Peter 1 Hall, Kerstin 1 Podskalny, Judith M. 1 Skottner, Anna 1 Moses, Alan C. 1; Affiliation:  1: Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, and Metabolism Branch, National Cancer Institute, National Institutes of Health Bethesda, Maryland; AB Kabi, Stockholm, and Department of Endocrinology, Karolinska Hospital Stockholm; Source Info: 1/2/78, Vol. 82 Issue 1, p5; Subject Term: SOMATOMEDIN; Subject Term: SOMATOTROPIN; Subject Term: PEPTIDES; Subject Term: GROWTH factors; Subject Term: PROTEINS; Subject Term: BIOCHEMISTRY; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pitha, Josef
T1  - Reagents Specific for Cell Surface Components.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/01/02/
VL  - 82
IS  - 1
M3  - Article
SP  - 285
EP  - 292
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Mercury, diazonium ions and dyes which bind nucleic acids were covalently linked to dextrans using methods that resulted in non-hydrolyzable reagent-dextran bonds without impairing the binding abilities of the reagents, i.e. these dextran derivatives reacted with thiols, phenols/ imidazoles and nucleic acids respectively. Since these dextran derivatives cannot penetrate into cells and since dextran itself does not bind to cells, these compounds represent reagents specific for the cell surface. They may be used both to evaluate cell surface constituents of intact cells and to affect viable cells via an interaction with those constituents. Mercury-dextran was found to bind to cells; the amount of mercury thus attached to the cells was about ten times smaller than when an equivalent concentration of free mercury ions was used. Mercury-dextran, bound to cells after a 30-min exposure at room temperature, was localized on the surface of these cells, as sodium borohydride reduced this complex giving rise to the intact cells, elementary mercury and free dextran which was released into medium. When cells were constantly exposed to the mercury-dextran, its toxic effects were comparable to that of free mercury ions. Diazonium-dextran, which also binds tightly to the cell surface, was also considerably toxic. Dextrans substituted with dyes which bind to nucleic acids were less toxic than the parent dyes themselves; it was shown that the attachment of such a dye to dextran decreased the binding of dye to cells under detection limits. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MERCURY
KW  - NUCLEIC acids
KW  - BIOMOLECULES
KW  - DEXTRAN
KW  - BLOOD plasma substitutes
KW  - BIOCHEMISTRY
N1  - Accession Number: 13605667; Pitha, Josef 1; Affiliation:  1: National Institutes of Health, National Institute on Aging-Gerontology Research Center, Baltimore City Hospitals, Baltimore, Maryland; Source Info: 1/2/78, Vol. 82 Issue 1, p285; Subject Term: MERCURY; Subject Term: NUCLEIC acids; Subject Term: BIOMOLECULES; Subject Term: DEXTRAN; Subject Term: BLOOD plasma substitutes; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Feldman, Stuart L.
AU  - Squibb, Katherine S.
AU  - Cousins, Robert J.
T1  - Degradation of cadmium‐thionein in rat liver and kidney.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1978/01/02/
VL  - 4
IS  - 5/6
M3  - Article
SP  - 805
EP  - 813
SN  - 00984108
AB  - [ 3  H]Cystine and 115mCd were incorporated into hepatic and renal Cd‐thionein in response to sc administration of 4.4 μmol of Cd 2+  containing 115mCd. Cd‐thioneinbound 115mCd reached a plateau by 24 and 72 h after the Cd  2+  injection in liver and kidney, respectively. The half‐life (t  ½  ) of  3  H‐labeled hepatic Cd‐thionein was 3.5 d, whereas the average t½  of the soluble proteins was 3.7 d. The t½  of  3 H‐labeled renal Cd‐thionein was 3.7 d, whereas the average t½  of the soluble renal proteins was 3.8 d. In marked contrast, the  115m Cd content of both hepatic and renal Cd‐thionein was virtually unchanged, even 9 d after administration of this radionuclide. These data indicate that the protein moiety of metallothionein is degraded, although there appears to be a concomitant rebinding of Cd 2+  to nascent thionein polypeptide chains. Thus the lack of metallothionein degradation per se does not account for the long‐term retention of Cd 2+  in liver and kidney during chronic exposure. [ABSTRACT FROM PUBLISHER]
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N1  - Accession Number: 76196190; Feldman, Stuart L. 1,2 Squibb, Katherine S. 1,3 Cousins, Robert J. 1,4; Affiliation:  1: Department of Nutrition, Rutgers University, New Brunswick, New Jersey  2: Department of Chemistry, Florida State University, Tallahassee, Florida, 32306  3: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina  4: Department of Nutrition, Cook College, Rutgers University, Thompson Hall, P.O. Box 231, New Brunswick, New Jersey, 08903; Source Info: Jan1978, Vol. 4 Issue 5/6, p805; Number of Pages: 9p; Document Type: Article
L3  - 10.1080/15287397809529701
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ong, Tong‐man
AU  - Slade, Barbara
T1  - Mutagenicity and mutagenic specificity of metronidazole and niridazole in neurospora crassa.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1978/01/02/
VL  - 4
IS  - 5/6
M3  - Article
SP  - 815
EP  - 824
SN  - 00984108
AB  - Mutagenicity and mutagenic specificity of niridazole and metronidazole, two chemotherapeutic agents used in the treatment of human parasitic diseases, were studied with the ad‐3 test system of Neurospora crassa. The results show that neither compound is mutagenic in resting conidia. In growing vegetative cells, however, both compounds are mutagenic in N. crassa. Genetic analysis of the mutants indicated that niridazole induces predominantly base‐pair substitution mutations. None of the niridazole‐induced mutants resulted from multilocus deletions. The spectra of genetic alterations induced by metronidazole are similar to those induced by the mono‐functional alkylating agents ethyleneimine (El), ethylmethanesulfonate (EMS), and ICR‐177. It is therefore suggested that the mechanism of mutation induction by metronidazole in Neurospora is similar to that of monofunctional alkylating agents. [ABSTRACT FROM PUBLISHER]
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N1  - Accession Number: 76196191; Ong, Tong‐man 1,2 Slade, Barbara 1; Affiliation:  1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina  2: National Institute for Occupational Safety and Health, ALOSH, Morgantown, West Virginia, 26505; Source Info: Jan1978, Vol. 4 Issue 5/6, p815; Number of Pages: 10p; Document Type: Article
L3  - 10.1080/15287397809529702
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Callen, D. F.
AU  - Larson, R. A.
T1  - Toxic and genetic effects of fuel oil photoproducts and three hydroperoxides in Saccharomyces cerevisiae.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1978/01/02/
VL  - 4
IS  - 5/6
M3  - Article
SP  - 913
EP  - 917
SN  - 00984108
AB  - Phototransformation of no. 2 fuel oil by UV irradiation at wavelengths designed to simulate sunlight resulted in the formation of products toxic to the yeast Saccharomyces cerevisiae. Increasing the time of irradiation of the fuel oil samples increased the toxicity. Fuel oil that had been irradiated for 12 or 24 h was convertagenic to the yeast strain D4. The toxicity and genetic activity of these samples could be removed by treatment with thiacyclohexane. It is thought that hydroperoxides are the primary photoproducts responsible for these biological effects. Of three hydroperoxides tested, tert ‐butyl was convertagenic and cumene and tetralin were not. However, all three hydroperoxides were toxic to yeast. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 76196200; Callen, D. F. 1,2 Larson, R. A. 1,3; Affiliation:  1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina  2: School of Biological Sciences, Flinders University of South Australia, Bedford Park, South Australia, 5042  3: Stroud Water Research Center, Academy of Natural Sciences of Philadelphia, Avondale, Pennsylvania; Source Info: Jan1978, Vol. 4 Issue 5/6, p913; Number of Pages: 5p; Document Type: Article
L3  - 10.1080/15287397809529711
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kauffman, Stuart A.
AU  - Shymko, Ronald M.
AU  - Trabert, Kenneth
T1  - Control of Sequential Compartment Formation in Drosophila.
JO  - Science
JF  - Science
Y1  - 1978/01/20/
VL  - 199
IS  - 4326
M3  - Article
SP  - 259
EP  - 270
SN  - 00368075
AB  - During development of Drosophila melanogaster, sequential commitment to alternative development programs occurs in neighboring groups of cells. These commitments appear to be reflected by lines of clonal restriction, called compartmental boundaries, which progressively subdivide the early embryo, and later the imaginal discs, which give rise to different adult appendages. We propose that a reaction- diffusion system acts throughout development and generates a sequence of differently shaped chemical patterns. These patterns account for the sequence and geometries of compartmental boundaries, and predict that each terminal compartment is specified by a unique combination of binary choices made during its formation. This binary "code" interprets coherently the patterned metaplasia seem in transdetermination and homeotic mutations. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87460085; Kauffman, Stuart A. 1; Shymko, Ronald M. 2; Trabert, Kenneth 3,4; Affiliations: 1: Associate Professor, Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19174; 2: Postdoctoral Feliow, Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19174; 3: Research Assistant, Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 4: Environmental Protection Agency, Washington, D.C.; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p259; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KINOSHITA, NADAO
AU  - GELBOIN, HARRY V.
T1  - β-Glucuronidase Catalyzed Hydrolysis of Benzo[a]pyrene-3-Glucuronide and Binding to DNA.
JO  - Science
JF  - Science
Y1  - 1978/01/20/
VL  - 199
IS  - 4326
M3  - Article
SP  - 307
EP  - 309
SN  - 00368075
AB  - β-Glucuronidase catalyzes the hydrolysis of benzo[a]pyrene-3-glucuronide to 3-hydroxybenzo[a]pyrene. During the enzymatic hydrolysis, a benzo[a]pyrene derivative is formed which binds to DNA to a far greater extent than either the 3-hydroxybenzo[a]pyrene or its glucuronide. These results suggest that conjugates of benzo[a]pyrene may be converted by β-glucuronidase at intracellular and organ sites distal to the initial sites of oxygenation and conjugation of benzo[a]pyrene to activated intermediates that are possibly carcinogenic. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460089; KINOSHITA, NADAO 1; GELBOIN, HARRY V. 1; Affiliations: 1: Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p307; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KLEIN, D. C.
AU  - BUDA, M. J.
AU  - KAPOOR, C. L.
AU  - KRISHNA, G.
T1  - Pineal Serotonin N-Acetyltransferase Activity: Abrupt Decrease in Adenosine 3',5'-Monophosphate May Be Signal for "Turnoff".
JO  - Science
JF  - Science
Y1  - 1978/01/20/
VL  - 199
IS  - 4326
M3  - Article
SP  - 309
EP  - 311
SN  - 00368075
AB  - Dispersed pinealocytes have been used to study the role of adenosine 3',5'-monophosphate (cyclic AMP) in the "turnoff" of N-acetyltransferase activity. Activity was first stimulated 100-fold by treating cells with l-norepinephrine. I-Propranolol acted stereospecifically to rapidly reverse this, resulting in a 70 percent loss of enzyme activity within 15 minutes. An even more rapid l-propranolol-induced decrease in cyclic AMP also occurred. This together with the observation that the inhibitory effect of l-propranolol on N-acetyltransferase was blocked by dibutyryl cyclic AMP and phosphodiesterase inhibitors indicate that an abrupt decrease in cyclic AMP may be the signal for the rapid decrease in pineal N-acetyltransferase activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460090; KLEIN, D. C. 1; BUDA, M. J. 1; KAPOOR, C. L. 2; KRISHNA, G. 2; Affiliations: 1: Neuroendocrinology Unit, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; 2: Section on Drug-Tissue Interaction, Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p309; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHMECHEL, DONALD
AU  - MARANGOS, PAUL J.
AU  - ZIS, ATHANASIOS P.
AU  - BRIGHTMAN, MILTON
AU  - GOODWIN, FREDERICK K.
T1  - Brain Enolases as Specific Markers of Neuronal and Glial Cells.
JO  - Science
JF  - Science
Y1  - 1978/01/20/
VL  - 199
IS  - 4326
M3  - Article
SP  - 313
EP  - 315
SN  - 00368075
AB  - There are three distinct enolase isoenzymes in brain: neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybridform. Light microscopy with immunocytochemical techniques has permitted localization of nonneuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87460100; SCHMECHEL, DONALD 1; MARANGOS, PAUL J.; ZIS, ATHANASIOS P.; BRIGHTMAN, MILTON 2; GOODWIN, FREDERICK K.; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neuropathology and Neuroanatomical Science, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p313; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MARCHALONIS, JOHN J.
AU  - BUCANA, CORA
AU  - HOYER, LARRY
AU  - WARR, GREGORY W.
AU  - HANNA, JR., M. G.
AU  - SZENBERG, ALEX
T1  - Visualization of a Guinea Pig T Lymphocyte Surface Component Cross-Reactive with Immunoglobulin.
JO  - Science
JF  - Science
Y1  - 1978/01/27/
VL  - 199
IS  - 4327
M3  - Article
SP  - 433
EP  - 435
SN  - 00368075
AB  - Thymus-derived lymphocytes (T cells) show exquisite specificity in recognition of antigens, but the nature of the cell surface receptor is controversial. Although antigen recognition mediated by immunoglobulin variable (V) regions remains the minimal hypothesis, it has been extremely difficult to definitely establish the presence of immunoglobulins on these cells. Chicken antibodies, produced against the (Fab')2 fragment of mouse immunoglobulin G (IgG) and purified by binding to and elution from IgG-Sepharose 4B, bind to an endogenously synthesized surface component of guinea pig T cells. The binding occurred via a cross-reaction with murine κ chain and a heavy chain determinant localized in the Fd region, and was visualized by immunofluorescence and immunoelectronmicroscopy using both transmission and scanning techniques. These data provide direct evidence for the presence of a surface component related to immunoglobulin on T lymphocytes. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87460135; MARCHALONIS, JOHN J. 1; BUCANA, CORA 1; HOYER, LARRY 1; WARR, GREGORY W. 1; HANNA, JR., M. G. 1; SZENBERG, ALEX 2; Affiliations: 1: Cancer Biology Program, National Cancer Institute, Frederick Cancer Research Center, Frederick, Maryland 21701; 2: Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Issue Info: 1/27/1978, Vol. 199 Issue 4327, p433; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kingman, Albert
T1  - Adequate cohort sizes for caries clinical trials.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1978/02//
VL  - 6
IS  - 1
M3  - Article
SP  - 30
EP  - 35
SN  - 03015661
AB  - Methods of determining cohort sizes were examined to determine their appropriateness for use in multi-group caries clinical trials. The appropriate method to use depends on the type of trial being planned. It is shown that multiple comparison methods using certain Bonferonni type t-statistics ought to be used in trials in which different levels or frequencies of application of known caries inhibitors are being tested. It is also demonstrated that using tile F-test procedure in the determination of cohort sizes can result in unacceptable low sensitivity levels being realized for the comparisons of primary concern. Tables are presented which can be used to determine group sizes needed to achieve specified sensitivity levels for two-group trials and multi-group trials. [ABSTRACT FROM AUTHOR]
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KW  - DENTAL caries
KW  - DENTAL pathology
KW  - CLINICAL trials
KW  - PREVENTIVE dentistry
KW  - ORAL hygiene
KW  - MEDICAL care -- Research
N1  - Accession Number: 12103524; Kingman, Albert 1; Affiliation:  1: Biometry Section, National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, U.S.A.; Source Info: Feb1978, Vol. 6 Issue 1, p30; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: CLINICAL trials; Subject Term: PREVENTIVE dentistry; Subject Term: ORAL hygiene; Subject Term: MEDICAL care -- Research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12103524
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Katz, Stephen I.
AU  - Strober, Warren
T1  - THE PATHOGENESIS OF DERMATITIS HERPETIFORMIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/02//
VL  - 70
IS  - 2
M3  - Article
SP  - 63
EP  - 75
SN  - 0022202X
AB  - Dermatitis herpetiformis is an intensely itchy papulovesicular eruption which is usually symmetrically distributed on extensor surfaces. The major areas of predilection are the elbows, knees, buttocks, scalp, posterior nuchal area, sacrum and shoulders; in addition, the face and facial hairline are occasionally affected and may be the only areas with lesions in patients who are otherwise adequately treated. The disease may start at any age, the late second and third decades being most common, and then persists indefinitely although it may vary in severity: There are a few patients in whom the immunologically verified disease remits for periods of months and even a few years in the absence of treatment.
KW  - SKIN -- Inflammation
KW  - ITCHING
KW  - IMMUNOLOGY
KW  - SKIN diseases
KW  - SKIN
KW  - FACE
N1  - Accession Number: 12541202; Katz, Stephen I. 1 Strober, Warren 1; Affiliation:  1: Dermatology and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb78, Vol. 70 Issue 2, p63; Subject Term: SKIN -- Inflammation; Subject Term: ITCHING; Subject Term: IMMUNOLOGY; Subject Term: SKIN diseases; Subject Term: SKIN; Subject Term: FACE; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1523-1747.ep12541202
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - RAPOPORT, JUDITH L.
AU  - BUCHSBAUM, MONTE S.
AU  - ZAHN, THEODORE P.
AU  - WEINGARTNER, HERBERT
AU  - LUDLOW, CHRISTY
AU  - MIKKELSEN, EDWIN J.
T1  - Dextroamphetamine: Cognitive and Behavioral Effects in Normal Prepubertal Boys.
JO  - Science
JF  - Science
Y1  - 1978/02/03/
VL  - 199
IS  - 4328
M3  - Article
SP  - 560
EP  - 563
SN  - 00368075
AB  - The behavioral, cognitive, and electrophysiological effect of a single dose of dextroamphetamine (0.5 milligram per kilogram of body weight) or placebo was examined in 14 normal prepubertal boys (mean age, 10 years 11 months) in a double-blind study. When amphetamine was given, the group showed a marked decrease in motor activity and reaction time and improved performance on cognitive tests. The similarity of the response observed in normal children to that reported in children with "hyperactivity" or minimal brain dysfunction casts doubt on pathophysiological models of minimal brain dysfunction which assume that children with this syndrome have a clinically specific or "paradoxical" response to stimulants. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87460194; RAPOPORT, JUDITH L. 1; BUCHSBAUM, MONTE S. 1; ZAHN, THEODORE P. 2; WEINGARTNER, HERBERT 2; LUDLOW, CHRISTY 3; MIKKELSEN, EDWIN J. 4; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Psychology and Psychopathology, National Institute of Mental Health; 3: Communicative Disorders Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; 4: Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 2/3/1978, Vol. 199 Issue 4328, p560; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MARY F. WALDROP
AU  - BELL, RICHARD Q.
AU  - MCLAUGHLIN, BRIAN
AU  - HALVERSON JR, CHARLES F.
T1  - Newborn Minor Physical Anomalies Predict Short Attention Span, Peer Aggression, and Impulsivity at Age 3.
JO  - Science
JF  - Science
Y1  - 1978/02/03/
VL  - 199
IS  - 4328
M3  - Article
SP  - 563
EP  - 565
SN  - 00368075
AB  - From a 5-to 10-minute newborn examination, behaviors of males at age 3 could be predicted. The number of minor physical anomalies, assessed soon after birth, was significantly related to a cluster of behaviors that are frequently labeled hyperactivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460201; MARY F. WALDROP 1; BELL, RICHARD Q. 2; MCLAUGHLIN, BRIAN 3; HALVERSON JR, CHARLES F. 4; Affiliations: 1: Laboratory of Developmental Psychology, National Institute of Health, Bethesda, Maryland 2001; 2: Department of Psychology, University of Virginia, Charlottesville 22904; 3: Laboratory of Developmental Psychology, National Institute of Mental Health; 4: College of Home Economics, University of Georgia, Athens 306; Issue Info: 2/3/1978, Vol. 199 Issue 4328, p563; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MALOFF, BRUCE L.
AU  - SCORDILIS, S. P.
AU  - TEDESCHI, HENRY
T1  - Membrane Potentials of Mitochondria.
JO  - Science
JF  - Science
Y1  - 1978/02/03/
VL  - 199
IS  - 4328
M3  - Article
SP  - 568
EP  - 569
SN  - 00368075
N1  - Accession Number: 87460184; MALOFF, BRUCE L. 1; SCORDILIS, S. P. 2; TEDESCHI, HENRY 3; Affiliations: 1: State University of New York, Upstate Medical Center, Syracuse 13210; 2: Section of Molecular Cardiology, National Institutes of Health, Bethesda, Maryland 20014; 3: Department of Biological Sciences and Neurobiology Center, State University of New York, Albany 12222; Issue Info: 2/3/1978, Vol. 199 Issue 4328, p568; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KOREEDA, MASATO
AU  - MOORE, PATRICK D.
AU  - WISLOCKI, PETER G.
AU  - LEVIN, WAYNE
AU  - CONNEY, ALLAN H.
AU  - YAGI, HARUHIKO
AU  - JERINA, DONALD M.
T1  - Binding of Benzo[a]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity.
JO  - Science
JF  - Science
Y1  - 1978/02/17/
VL  - 199
IS  - 4330
M3  - Article
SP  - 778
EP  - 781
SN  - 00368075
AB  - The formation, stereostructure, and cellular reactions of the 7,8-diol- 9,10-epoxide metabolites of the carcinogen benzo[a]pyrene have been examined after topical application of benzo[a]pyrene to the skin of mice. In this known target tissue, polymer adducts from diastereomeric diol epoxides, (+)-(7S, 8R, 9R, ]OR) and (+)-(7R, 8S, 9R, ]OR), were formed stereospecifically from their corresponding 7,8-dihydrodiols. Both diol epoxides bind with proteins, RNA, and DNA in vivo. For the nucleic acids, binding occurs preferentially at the 2-amino group of guanine in cellular RNA and DNA in vivo. Methods for establishing the structure of the cellular adducts as well as the possible biological implications of their formation are discussed. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87460785; KOREEDA, MASATO 1; MOORE, PATRICK D. 1; WISLOCKI, PETER G. 2; LEVIN, WAYNE 2; CONNEY, ALLAN H. 2; YAGI, HARUHIKO 3; JERINA, DONALD M. 3; Affiliations: 1: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218; 2: Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110; 3: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/17/1978, Vol. 199 Issue 4330, p778; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROSEN, LEON
AU  - TESH, ROBERT B.
AU  - JIH CHING LIEN
AU  - CROSS, JOHN H.
T1  - Transovarial Transmission of Japanese Encephalitis Virus by Mosquitoes.
JO  - Science
JF  - Science
Y1  - 1978/02/24/
VL  - 199
IS  - 4331
M3  - Article
SP  - 909
EP  - 911
SN  - 00368075
AB  - Female Aedes albopictus and Aedes togoi mosquitoes infected with Japanese encephalitis virus either by intrathoracic inoculation or by ingestion of a virussucrose-erythrocyte mixture transmitted the virus to a small percentage of their F1 progeny. Adult F1 female Aedes albopictus thus infected transmitted the virus in turn to newly hatched chickens by feeding on them. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87460830; ROSEN, LEON 1; TESH, ROBERT B. 1; JIH CHING LIEN 2; CROSS, JOHN H. 2; Affiliations: 1: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806; 2: U.S. Naval Medical Research Unit No. 2, Taipei, Taiwan; Issue Info: 2/24/1978, Vol. 199 Issue 4331, p909; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - NEWS
AU  - Darby, William J.
AU  - Mason, Karl E.
T1  - Cultural Food Patterns and Nutrition.
JO  - BioScience
JF  - BioScience
Y1  - 1978/03//
VL  - 28
IS  - 3
M3  - Editorial
SP  - 159
EP  - 159
SN  - 00063568
AB  - The article presents the authors' opinion on cultural patterns of food and nutrition. According to the authors, concerns relating to food have become major public issues and have been pervaded by both political influences and religious emotionalism. They opine that serious scholars including Humanists and historians, have much to contribute to the clarification and understanding of food wants and cultural needs and in sorting value judgments related to present-day issues concerning food.
KW  - Food -- Quality
KW  - Nutrition
KW  - Scholars
KW  - Food science
N1  - Accession Number: 28050598; Darby, William J. 1; Mason, Karl E. 2; Affiliations: 1 : Nutrition Foundation, Inc. 489 Fifth Avenue New York, NY 10017; 2 : National Institute of Arthritis, Metabolism and Digestive Diseases National Institutes of Health Bethesda, MD 20014;  Source Info: Mar1978, Vol. 28 Issue 3, p159; Subject Term: Food -- Quality; Subject Term: Nutrition; Subject Term: Scholars; Subject Term: Food science; Number of Pages: 1p; Document Type: Editorial; Full Text Word Count: 491
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Sohnle, Peter G.
AU  - Kirkpatrick, Charles H.
T1  - EPIDERMAL PROLIFERATION IN THE DEFENSE AGAINST EXPERIMENTAL CUTANEOUS CANDIDIASIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/03//
VL  - 70
IS  - 3
M3  - Article
SP  - 130
EP  - 133
SN  - 0022202X
AB  - In previous studies we implicated scaling of the stratum corneum as being important in the clearance of experimental cutaneous <em>Candida</em> infections in guinea pigs. In this model the scaling response appeared to be intensified by delayed hypersensitivity reactions to <em>Candida</em> antigens and to be responsible for the more rapid clearance of infecting organisms by immune animals. The present studies were undertaken to quantitate the degree of epidermal proliferation in such <em>Candida</em> infections and to relate it to delayed hypersensitivity reactions as well as other types of inflammation. The two parameters of epidermal proliferation studied were incorporation of tritiated thymidine by basal cells and thickening of the malpighian layer; both were increased markedly in <em>Candida</em>-infected skin of immune animals and also to a lesser extent in <em>Candida</em>-infected skin of nonimmune animals. Positive delayed skin test responses to <em>Candida</em> antigens were associated with increased basal cell thymidine incorporation, but negative delayed responses were not. Inflammation caused by intradermal injection of irritants was also associated with increased basal cell thymidine incorporation. These results indicate that delayed hypersensitivity reactions in experimental cutaneous <em>Candida</em> infections act to increase the rate of basal cell turnover, primarily by producing increased inflammation in the lesions. The role of delayed hypersensitivity appears to be nonspecific, since other forms of inflammation are also capable of causing increased epidermal proliferation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANDIDIASIS
KW  - EPIDERMIS
KW  - INFECTION
KW  - DELAYED hypersensitivity
KW  - INFLAMMATION
KW  - GUINEA pigs as laboratory animals
N1  - Accession Number: 12258536; Sohnle, Peter G. 1,2 Kirkpatrick, Charles H. 1,2; Affiliation:  1: The Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; The Infectious Disease Section, Medial Service, Veterans Administration Center, Wood (Milwaukee), Wisconsin  2: Laboratory of Clinical Investigation, National Institue of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, U.S.A; Source Info: Mar1978, Vol. 70 Issue 3, p130; Subject Term: CANDIDIASIS; Subject Term: EPIDERMIS; Subject Term: INFECTION; Subject Term: DELAYED hypersensitivity; Subject Term: INFLAMMATION; Subject Term: GUINEA pigs as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12258536
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dunham, George S.
AU  - Pacak, Milos G.
AU  - Pratt, Arnold W.
T1  - Automatic Indexing of Pathology Data.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
Y1  - 1978/03//
VL  - 29
IS  - 2
M3  - Article
SP  - 81
EP  - 90
SN  - 00028231
AB  - A procedure for automated indexing of pathology diagnostic reports at the National Institutes of Health is described. Diagnostic statements in medical English are encoded by computer into the Systematized Nomenclature of Pathology (SNOP). SNOP is a structured indexing language constructed by pathologists for manual indexing. It is of interest that effective automatic encoding can be based upon an existing vocabulary and code designed for manual methods. Morphosyntactic analysis, a simple syntax analysis, matching of dictionary entries consisting of several words, and synonym substitutions are techniques utilized. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL care
KW  - PREVENTIVE medicine
KW  - DISEASES
KW  - SYNTAX (Grammar)
KW  - ENVIRONMENTAL medicine
KW  - IMMUNIZATION
N1  - Accession Number: 18063785; Dunham, George S. 1; Pacak, Milos G. 1; Pratt, Arnold W. 1; Affiliations: 1: Division of Computer Research and Technology, National institutes of Health, Bethesda, MD 20014.; Issue Info: Mar1978, Vol. 29 Issue 2, p81; Thesaurus Term: MEDICAL care; Subject Term: PREVENTIVE medicine; Subject Term: DISEASES; Subject Term: SYNTAX (Grammar); Subject Term: ENVIRONMENTAL medicine; Subject Term: IMMUNIZATION; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Feldman, Saul
T1  - CONFLICT & CONVERGENCE: THE MENTAL HEALTH PROFESSIONAL IN GOVERNMENT.
JO  - Public Administration Review
JF  - Public Administration Review
Y1  - 1978/03//Mar/Apr78
VL  - 38
IS  - 2
M3  - Article
SP  - 139
EP  - 144
PB  - Wiley-Blackwell
SN  - 00333352
AB  - The article focuses on the role and influence of mental health professionals in government agencies in the U.S. Unlike general health care with its dependence on the private sector, the development of the mental health field largely has been the result of government action. Stimulated by the availability of state matching funds, local governments also have become heavily involved in mental health. The role of government as a major employer of mental health professionals is illustrated by a study of 10,000 mental health professionals whose training during the years 1948-1968 was supported at least in part by the National Institute of Mental Health. This dependence of the mental health field upon government is not reflected in the graduate education of mental health professionals. For the mental health professional who is also an administrator, there are several special attitudinal issues. The values of caring, support and therapy are often inconsistent with the exercise of power, the directive and perhaps authoritative stance sometimes necessary for successful administration.
KW  - MENTAL health personnel
KW  - PROFESSIONAL employees
KW  - CIVIL service
KW  - GOVERNMENT agencies
KW  - GOVERNMENT policy
KW  - MENTAL health
KW  - MENTAL health policy
KW  - PUBLIC health
KW  - ATTITUDE (Psychology)
KW  - UNITED States
N1  - Accession Number: 4613430; Feldman, Saul 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Mar/Apr78, Vol. 38 Issue 2, p139; Thesaurus Term: MENTAL health personnel; Thesaurus Term: PROFESSIONAL employees; Thesaurus Term: CIVIL service; Thesaurus Term: GOVERNMENT agencies; Thesaurus Term: GOVERNMENT policy; Subject Term: MENTAL health; Subject Term: MENTAL health policy; Subject Term: PUBLIC health; Subject Term: ATTITUDE (Psychology); Subject: UNITED States; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - MOUTSOPOULOS, HARALAMPOS M.
AU  - CHUSED, THOMAS M.
AU  - JOHNSON, ARMEAD H.
AU  - KNUDSEN, BODIL
AU  - MANN, DEAN L.
T1  - B Lymphocyte Antigens in Sicca Syndrome.
JO  - Science
JF  - Science
Y1  - 1978/03/31/
VL  - 199
IS  - 4336
M3  - Article
SP  - 1441
EP  - 1442
SN  - 00368075
AB  - All individuals tested in this study with sicca syndrome, a human autoimmune disease, bear two immunologically distinct and genetically unrelated B lymphocyte antigens that appear similar to the immune response associated (Ia) antigens of the mouse. The genes coding for these two antigens are present in only 37 and 24 percent of normal controls. In animal models Ia antigen genes are closely linked to immune response genes. Our findings suggest that two such genes may be required for the development of sicca syndrome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436632; MOUTSOPOULOS, HARALAMPOS M. 1; CHUSED, THOMAS M. 1; JOHNSON, ARMEAD H. 2; KNUDSEN, BODIL 3; MANN, DEAN L. 3; Affiliations: 1: Clinical Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland 20014; 2: Division of Immunology, Duke University Medical Center, Durham, North Carolina 27710; 3: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1441; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KOZAK, CHRISTINE
AU  - ROWE, WALLACE P.
T1  - Genetic Mapping of Xenotropic Leukemia Virus-Inducing Loci in Two Mouse Strains.
JO  - Science
JF  - Science
Y1  - 1978/03/31/
VL  - 199
IS  - 4336
M3  - Article
SP  - 1448
EP  - 1449
SN  - 00368075
AB  - In genetic studies of C57BLI1O and BALBIc mice, inducibility of xenotropic murine leukemia virus from tissue cultures by treatment with 5-iododeoxyuridine shows single gene segregation ratios. In both strains, the virus-inducing loci are on chromosome 1, linked to the Dip-I isozyme locus, but the two may not be at allelic sites. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436626; KOZAK, CHRISTINE 1; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1448; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MACDONALD, ROBERT L.
AU  - NELSON, PHILLIP G.
T1  - Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture.
JO  - Science
JF  - Science
Y1  - 1978/03/31/
VL  - 199
IS  - 4336
M3  - Article
SP  - 1449
EP  - 1451
SN  - 00368075
AB  - The opiate etorphine depresses monosynaptic excitatory postsynaptic potentials (EPSP's) elicited in spinal cord cells by activation of dorsal root ganglion cells in murine neuronal cell culture. The depression is reversed by naloxone. Statistical analysis of the synaptic responses reveals that the opiate reduces EPSP quantal content at this synapse without altering quantal size. Therefore, the opiate action is presynaptic and affects transmitter release rather than postsynaptic responsiveness. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436630; MACDONALD, ROBERT L. 1,2; NELSON, PHILLIP G. 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; 2: Department of Neurology, University of Virginia, Charlottesville 22901; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1449; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, J. L.
AU  - NEALE, J. H.
AU  - SMITH, JR., T. G.
AU  - MACDONALD, R. L.
T1  - Opiate Peptide Modulation of Amino Acid Responses Suggests Novel Form of Neuronal Communication.
JO  - Science
JF  - Science
Y1  - 1978/03/31/
VL  - 199
IS  - 4336
M3  - Article
SP  - 1451
EP  - 1453
SN  - 00368075
AB  - Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action-of opiate peptide functionally distinct from the conventional neurotransmitter class of operation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436614; BARKER, J. L. 1; NEALE, J. H. 2; SMITH, JR., T. G. 1; MACDONALD, R. L. 3; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, and Department of Biology, Georgetown University, Washington, D.C.; 3: Laboratory of Developmental Neutrobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1451; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Garn, Stanley M.
AU  - Shaw, Helen A.
AU  - McCabe, Kinne D.
T1  - Effect of maternal smoking on hemoglobins and hematocrits of the newborn.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1978/04//
VL  - 31
IS  - 4
M3  - Article
SP  - 557
EP  - 558
SN  - 00029165
N1  - Accession Number: 94355773; Garn, Stanley M. 1; Shaw, Helen A. 1; McCabe, Kinne D. 2; Affiliations: 1: Center for Human Growth and Development and Nutrition Unit, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109; 2: The Collaborative Perinatal Project, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: Apr1978, Vol. 31 Issue 4, p557; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hunninghake, G. W.
AU  - Haynes, B. F.
AU  - Parrillo, J. E.
AU  - Fauci, A. S.
T1  - Comparison of the relative cytotoxic effector cell capabilities and the proportions of cells bearing various surface markers in human tonsil and peripheral blood mononuclear cells.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/04//
VL  - 32
IS  - 1
M3  - Article
SP  - 186
EP  - 191
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The relative cytotoxic effector cell capabilities and the proportions of cells bearing various surface markers in human tonsil and peripheral blood mononuclear cells has been studied. The peripheral blood contained a substantial proportion of monocytes (22± 2'9%) compared to tonsil cell suspensions (25±0.3%). The percentages of T lymphocytes was significantly higher in the blood than in the tonsil (P < 0.01); however, the percentages of cells forming rosettes with 7S EA were not significantly different in each group (P>0.5). Mitogen-induced cellular cytotoxicity by blood and tonsil mononuclear cells against Chang cells was proportional to the percentages of T lymphocytes in these cell suspensions, and both antibody-dependent and mitogen-induced cellular cytoxicity against sheep red blood cells was proportional to the percentages of monocytes in these suspensions. Tonsil mononuclear cell suspensions were incapable of mediating antibody-dependent cellular cytotoxicity against Chang cells, whereas blood mononuclear cells functioned normally. These findings are in contrast to the findings of similar percentages of Fc receptor-positive lymphocytes in blood and tonsil mononuclear cell suspensions. Previous studies have shown that the effector cells against antibody-coated Chang cells are Fc receptor-positive lymphocytes. These studies show that in the case of cytotoxicity mediated by an Fc receptor-bearing lymphoid cell, there may be a clear discrepancy between the relative proportions of Fc-bearing lymphoid cells in different organs and the relative levels of cytotoxicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TONSILS
KW  - MONOCYTES
KW  - LEUCOCYTES
KW  - T cells
KW  - CELL suspensions
KW  - CELL culture
N1  - Accession Number: 16108831; Hunninghake, G. W. 1 Haynes, B. F. 1 Parrillo, J. E. 1 Fauci, A. S. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr1978, Vol. 32 Issue 1, p186; Subject Term: TONSILS; Subject Term: MONOCYTES; Subject Term: LEUCOCYTES; Subject Term: T cells; Subject Term: CELL suspensions; Subject Term: CELL culture; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Harford, Thomas C.
AU  - Blane, Howard T.
AU  - Crafetz, Morris E.
T1  - PSYCHOLINGUISTIC CORRELATES OF LANGUAGE PREDICTABILITY IN PSYCHIATRIC INTERVIEWS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1978/04//
VL  - 34
IS  - 2
M3  - Article
SP  - 501
EP  - 505
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article presents information on language predictability in psychiatric interviews. The present study seeks to replicate the previous finding of shifts in predictability in initial psychiatric interviews and its correlation with post-interview ratings. In addition, correlations between several measures of anxiety and immediacy with shifts in predictability are examined. It is hypothesized that decreases in predictability as an interview progresses will be accompanied by an increase in anxiety tension, less common word usage, and immediacy. Samples of speech of patients were obtained from 14 tape-recorded initial intake interviews in an outpatient clinic of a general hospital. Two speech samples, of 105 words each, were extracted from the initial and terminal portions of each interview.
KW  - INTERVIEWING in psychiatry
KW  - INTERVIEWING in mental health
KW  - PSYCHOTHERAPY
KW  - STRESS (Psychology)
KW  - ANXIETY
KW  - PATIENTS
N1  - Accession Number: 15845365; Harford, Thomas C. 1 Blane, Howard T. 2 Crafetz, Morris E. 3; Affiliation:  1: National Institute of Alcohol Abuse and Alcoholism.  2: University of Pittsburgh.  3: Johns Hopkins University.; Source Info: Apr1978, Vol. 34 Issue 2, p501; Subject Term: INTERVIEWING in psychiatry; Subject Term: INTERVIEWING in mental health; Subject Term: PSYCHOTHERAPY; Subject Term: STRESS (Psychology); Subject Term: ANXIETY; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yaoita, Hideo
AU  - Foidart, Jean-Michel
AU  - Katz, Stephen I.
T1  - LOCALIZATION OF THE COLLAGENOUS COMPONENT IN SKIN BASEMENT MEMBRANE.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/04//
VL  - 70
IS  - 4
M3  - Article
SP  - 191
EP  - 193
SN  - 0022202X
AB  - Antibodies to type IV collagen were produced by immunizing rabbits with a basement membrane collagen obtained from a transplantable mouse tumor. Using specifically purified antibodies, type IV collagen was localized ultrastructurally to the basal lamina part of the basement membrane zone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLLAGEN
KW  - SKIN
KW  - BASAL lamina
KW  - IMMUNOGLOBULINS
KW  - IMMUNIZATION
KW  - RABBITS as laboratory animals
KW  - TUMORS
N1  - Accession Number: 12541313; Yaoita, Hideo 1,2 Foidart, Jean-Michel 1,2 Katz, Stephen I. 1,2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr78, Vol. 70 Issue 4, p191; Subject Term: COLLAGEN; Subject Term: SKIN; Subject Term: BASAL lamina; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNIZATION; Subject Term: RABBITS as laboratory animals; Subject Term: TUMORS; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12541313
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Otani, T. T.;
AU  - Briley, M. R.;
T1  - Effect of acylated amino acids and acylated amino acid analogs on microbial antitumor screen
CT  - Effect of acylated amino acids and acylated amino acid analogs on microbial antitumor screen
JO  - Journal of Pharmaceutical Sciences (USA)
JF  - Journal of Pharmaceutical Sciences (USA)
Y1  - 1978/04/01/
VL  - 67
IS  - Apr
SP  - 520
EP  - 526
SN  - 00223549
AD  - Nucleic Acids Sec., Lab. of Pathophysiology, National Cancer Institute, NIH, Bethesda, MD 20014
N1  - Accession Number: 16-1847; Language: English; References: 17; Journal Coden: JPMSAE; Section Heading: Microbiology; Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2  - A series of N-acetyl, N-propionyl and N-chloracetyl derivatives of amino acids and amino acid analogs was tested for growth inhibitory activity using a Lactobacillus casei system as a prescreen for possible antitumor activity. The chloracetyl derivatives, especially those of essential amino acids and of their analogs, showed modest but pharmacologically significant inhibition, while those of nonessential amino acids exhibited no activity.
KW  - Amino acids--and derivatives--effects, antitumor, Lactobacillus casei screen;
KW  - Structure-activity relationships--amino acids--and derivatives, antitumor effects, Lactobacillus casei screen;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 2013-42915-021
AN  - 2013-42915-021
AU  - Yarrow, Leon J.
T1  - Review of Temperament and development.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1978/04//
VL  - 48
IS  - 2
SP  - 359
EP  - 360
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42915-021. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Emotional States; Persistence; Personality Development. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Reviewed Item: Thomas, Alexander; Chess, Stella. Temperament and development=270 pp. $13.50. Brunner/Mazel, New York; 1977. Page Count: 2. Issue Publication Date: Apr, 1978. 
AB  - Reviews the book, Temperament and Development by Alexander Thomas and Stella Chess (1977). The authors attempted to document individual differences in what were called primary reaction patterns early in infancy. The book distinguishes nine categories of temperment: activity, rhythmicity, adaptability, approach/withdrawal, threshold of responsiveness, intensity of reaction, mood, distractibility and persistence. A major theme running through this book is that the organism and environment are separable only as a convenience for study. The authors stress the reciprocal relationship between characteristics of the child and environmental opportunities, demands, and stresses. Throughout the book, the discussion is reasoned and the authors do not make extreme claims for the primacy of temperamental attributes or reject the importance of the environment. With regard to early environmental determinism, the authors cite data from diverse sources that question the simple, long-held, and cherished conviction that the impact of early experience is irreversible. The ideas presented by the authors are provocative and they stimulate our thinking about the term and emphasize the need for clarification of the concept. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - temperament
KW  - adolescent development
KW  - personality growth
KW  - mood distractibility
KW  - persistence
KW  - 1978
KW  - Adolescent Development
KW  - Emotional States
KW  - Persistence
KW  - Personality Development
KW  - 1978
U2  - Thomas, Alexander; Chess, Stella. (1977); Temperament and development; 270 pp. $13.50. Brunner/Mazel, New York
DO  - 10.1037/h0098959
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SPRING, KENNETH R.
AU  - HOPE, ARVID
T1  - Size and Shape of the Lateral Intercellular Spaces in a Living Epithelium.
JO  - Science
JF  - Science
Y1  - 1978/04/07/
VL  - 200
IS  - 4337
M3  - Article
SP  - 54
EP  - 58
SN  - 00368075
AB  - The lateral intercellular spaces of Necturus gallbladder epithelium were seen and measured while the living tissue was perfused in a new chamber. The compliance of the lateral cell membranes was calculated from the measured pressure-volume characteristics of the lateral intercellular spaces. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87437122; SPRING, KENNETH R. 1; HOPE, ARVID 1; Affiliations: 1: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 4/7/1978, Vol. 200 Issue 4337, p54; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 84007916
T1  - Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy.
AU  - Peylan-Ramu, Nili
AU  - Poplack, David G.
AU  - Pizzo, Philip A.
AU  - Adornato, Bruce T.
AU  - Di Chiro, Giovanni
AU  - Peylan-Ramu, N
AU  - Poplack, D G
AU  - Pizzo, P A
AU  - Adornato, B T
AU  - Di Chiro, G
Y1  - 1978/04/13/
N1  - Accession Number: 84007916. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Reynolds Adolescent Depression Scale (RADS). NLM UID: 0255562. 
KW  - Methotrexate -- Administration and Dosage
KW  - Tomography, X-Ray Computed
KW  - Meningeal Neoplasms -- Prevention and Control
KW  - Cytarabine -- Administration and Dosage
KW  - Leukemia, Lymphocytic -- Therapy
KW  - Brain
KW  - Brain -- Radiation Effects
KW  - Child, Preschool
KW  - Cytarabine -- Therapeutic Use
KW  - Injections, Intraspinal
KW  - Adolescence
KW  - Leukemia, Lymphocytic -- Drug Therapy
KW  - Infant
KW  - Leukemia, Lymphocytic -- Radiotherapy
KW  - Methotrexate -- Therapeutic Use
KW  - Child
KW  - Human
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Randomized Controlled Trials
KW  - Psychological Tests
SP  - 815
EP  - 818
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 298
IS  - 15
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - Thirty-two asymptomatic patients with acute lymphocytic leukemia, who had received prophylactic cranial radiation (2400 rads) and either intrathecal methotrexate or cytosine arabinoside were studied by computed tomography of the brain 19 to 67 months after initiation of prophylaxis. Seventeen of 32 (53 per cent) had one or more abnormal findings. Dilatation of the ventricles (eight patients) and widening of the subarachnoid spaces (nine patients) were equally distributed among patients in both intrathecal-chemotherapy groups. Areas of decreased attenuation coefficient (hypodense, abnormally radiolucent regions) (four patients) and intracerebral calcification (one patient)--lesions previously described in methotrexate leukoencephalopathy--were found only in those who had received intrathecal methotrexate. Mild central-nervous-system dysfunction was detected in seven patients but did not correlate with the presence of tomographic abnormalities. Nevertheless, these tomographic findings may represent preclinical lesions. The unexpectedly high prevalence of such abnormalities contrasts with the essentially normal tomographic findings in a control group with acute lymphocytic leukemia who received no central-nervous-system prophylaxis. These results suggest that alternative approaches to such prophylaxis be considered.
SN  - 0028-4793
AD  - From the Pediatric Oncology Branch, National Cancer Institute, and the Medical Neurology Branch and Section on Neuroradiology, Neurosurgery Branch, National Institute of Neurological and Communicative Disorders and Stroke (address reprint requests to Dr. Poplack at Bldg. 10, Rm. 3B–03, National Institutes of Health, Bethesda, MD 20014).
U2  - PMID: 273143.
DO  - 10.1056/NEJM197804132981504
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Phillips, Don R.
AU  - DiMarco, Aurelio
AU  - Zunino, Franco
T1  - The Interaction of Daunomycin with Polydeoxynucleotides.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/04/17/
VL  - 85
IS  - 2
M3  - Article
SP  - 487
EP  - 492
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The ability of daunomycin to bind to various DNA polymers has been studied by thermal denaturation, spectrophotometric analysis and inhibition of the polymerisation reactions catalysed by Escherichia coli DNA polymerase 1 and rat liver DNA polymerase α. The quantitative binding measurements revealed that the antibiotic binds tightly to all synthetic polydeoxynucleotides studied. The results demonstrated that daunomycin can bind with equal affinity to dG · dC or dA · dT base-paired sequences. However, the number of binding sites per nucleotide for poly(dA) · poly(dT) is significantly lower than that found for poly(dA-dT) · poly(dA-dT), thus indicating an appreciable preference of the drug for the alternating copolymer. The inactivation of the template properties of the synthetic DNA polymers in the DNA polymerase system is consistent with their daunomycin binding ability. However, a lack of correlation was observed between the drug binding ability of different DNA polymers and the binding-induced stabilisation of the double helix to heat denaturation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DAUNOMYCIN
KW  - POLYMERS
KW  - ENZYMES
KW  - NUCLEIC acids
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
N1  - Accession Number: 13645366; Phillips, Don R. 1 DiMarco, Aurelio 1 Zunino, Franco 1; Affiliation:  1: Department of Biochemistry, La Trobe and Division of Experimental Oncology B, National Cancer Institute, Milan; Source Info: 4/17/78, Vol. 85 Issue 2, p487; Subject Term: DAUNOMYCIN; Subject Term: POLYMERS; Subject Term: ENZYMES; Subject Term: NUCLEIC acids; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenberg, Hagai
AU  - Singer, Maxine
AU  - Rosenberg, Martin
T1  - Highly Reiterated Sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN.
JO  - Science
JF  - Science
Y1  - 1978/04/28/
VL  - 200
IS  - 4340
M3  - Article
SP  - 394
EP  - 402
SN  - 00368075
AB  - A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546542; Rosenberg, Hagai 1,2; Singer, Maxine 3; Rosenberg, Martin 3; Affiliations: 1: Visiting Fellow, National Cancer Institute, Bethesda, Maryland 20014,; 2: Israel Institute for Biological Research, Prime Minister's Office, Ness Ziona P.O.B. 19 Israel; 3: Laboratory of Biochemistry and Laboratory of Molecular Biology, respectively, National Cancer Society; Issue Info: 4/28/1978, Vol. 200 Issue 4340, p394; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DES RoSIERS, M. H.
AU  - SAKURADA, O.
AU  - JEHLE, J.
AU  - SHINOHARA, M.
AU  - KENNEDY, C.
AU  - SOKOLOFF, L.
T1  - Functional Plasticity in the Immature Striate Cortex of the Monkey Shown by the ["C]Deoxyglucose Method.
JO  - Science
JF  - Science
Y1  - 1978/04/28/
VL  - 200
IS  - 4340
M3  - Article
SP  - 447
EP  - 449
SN  - 00368075
AB  - Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of the ocular dominance columns in the striate cortex of the monkey in the first day of life. In contrast to the stability of these columns in more mature brain, monocular deprivation for 3 months from the first day of life results in their complete disappearance and a reversion of the autoradiographic pattern to that seen in animals with normal binocular vision. These results are consistent with a reorganization of the representation of the visual fields of the two eyes in the striate cortex and provide additional evidence of the plasticity of the striate cortex of the monkey in early life . [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546521; DES RoSIERS, M. H. 1; SAKURADA, O. 1; JEHLE, J. 1; SHINOHARA, M. 1; KENNEDY, C. 2; SOKOLOFF, L. 3; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C. 20007; 3: Laboratory of Cerebral Metabolism, National Institute ofMental Health; Issue Info: 4/28/1978, Vol. 200 Issue 4340, p447; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Leong, D.
AU  - Coe, J.E.
T1  - Metabolism of homologous and heterologous serum proteins in garter snakes (<em> Thamnophis ordinoides </em>).
JO  - Immunology
JF  - Immunology
Y1  - 1978/05//
VL  - 34
IS  - 5
M3  - Article
SP  - 931
EP  - 937
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The half life (T½) of serum immunoglobulin (Ig) and albumin from snakes and mammals were determined in both garter snakes (Thamnophis ordinoides) and mice (Mus musculus). Metabolism of serum proteins in snakes was similar to mammalian protein metabolism in that homologous serum albumin had shorter T½ (16 days) than IgG (38 days). Also, reptilian and mammalian serum proteins had a relatively longer T½ when injected into closely related species. Thus mammalian serum Ig (rabbit gamma globulin (RGG)) had a shorter T½ (6.3 days) in snake than did homologous snake IgG (38 days), whereas in mice, RGG had a longer T½ (3.8 days) than snake Ig (0.9 days). Differences between metabolism of homologous and heterologous albumins were apparent only in snakes in which the T½. of homologous albumin was approximately 8-fold greater than mammalian albumin. These results indicate that metabolism of both Ig and albumin in snakes is regulated by specific receptors whereas albumin receptors have been difficult to demonstrate in mammals. The results of this study suggest that one of the factors determining the metabolism of a protein is its foreignness to the host perhaps because of receptor cross reactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLOOD proteins
KW  - GARTER snakes
KW  - THAMNOPHIS ordinoides
KW  - IMMUNOGLOBULINS
KW  - PROTEIN metabolism
KW  - MAMMALS
KW  - SERUM
KW  - ALBUMINS
N1  - Accession Number: 13930713; Leong, D. 1 Coe, J.E. 1; Affiliation:  1: Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Moutain Laboratory, Hamilton, Montana, U.S.A.; Source Info: May78, Vol. 34 Issue 5, p931; Subject Term: BLOOD proteins; Subject Term: GARTER snakes; Subject Term: THAMNOPHIS ordinoides; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEIN metabolism; Subject Term: MAMMALS; Subject Term: SERUM; Subject Term: ALBUMINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Snippe, H.
AU  - Johannesen, Lynne
AU  - Inman, J.K.
AU  - Merchant, B.
T1  - Specificity of murine delayed-type hypersensitivity to conjugates of large or small haptens on protein carriers bearing lipid groups.
JO  - Immunology
JF  - Immunology
Y1  - 1978/05//
VL  - 34
IS  - 5
M3  - Article
SP  - 947
EP  - 954
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Delayed-type hypersensitivity (DH) in the mouse was provoked with different haptencarrier complexes mixed with the cationic, surfaceactive lipid, dimethyl dioctadecyl ammonium bromide (DDA). DH was measured as footpad swelling.Conjugates of bovine serum albumin (BSA) with the small haptens dinitrophenyl (DNP), 'arsonate'(ARS) and 'sulphonate' (SULPH) served to generate strong DH reactions towards the homologous antigen. Insertion of a tripeptide spacer between the hapten and carrier resulted in lower DH reactivity. Optimal dosages and optimal time intervals between sensitization and DH elicitation were determined for the enlarged hapten-carrier complexes. Cyclophosphamide (CY) treatment, before priming with complexes mixed with DDA, caused a 5-6 day delay in the expression of DH but failed to evoke enhanced DH for any of the antigens tested. A broad array of cross reactions between small and enlarged hapten-carrier complexes showed a relative lack of specificity in these DH responses. The results are compared with others reported in the literature and are explained mainly by the effects of electrostatically bound lipid groups of DDA in the sensitizing conjugates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DELAYED hypersensitivity
KW  - MICE
KW  - SERUM albumin
KW  - HAPTENS
KW  - ANTIGENS
KW  - CARRIER proteins
KW  - BROMIDES
N1  - Accession Number: 13932691; Snippe, H. 1 Johannesen, Lynne 1 Inman, J.K. 1 Merchant, B. 1; Affiliation:  1: Division and Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: May78, Vol. 34 Issue 5, p947; Subject Term: DELAYED hypersensitivity; Subject Term: MICE; Subject Term: SERUM albumin; Subject Term: HAPTENS; Subject Term: ANTIGENS; Subject Term: CARRIER proteins; Subject Term: BROMIDES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - RPRT
AU  - Andrews, Alan D.
AU  - Barrett, Susanna F.
AU  - Yoder, Frank W.
AU  - Robbins, Jay H.
T1  - COCKAYNE'S SYNDROME FIBROBLASTS HAVE INCREASED SENSITIVITY TO ULTRAVIOLET LIGHT BUT NORMAL RATES OF UNSCHEDULED DNA SYNTHESIS.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/05//
VL  - 70
IS  - 5
M3  - Report
SP  - 237
EP  - 239
SN  - 0022202X
AB  - Cockayne's syndrome is a form of cachectic dwarfism characterized by acute sun sensitivity and numerous other abnormalities of many organ systems. We studied fibroblasts from 9 Cockayne's syndrome patients to determine if their fibroblasts had abnormal post-ultraviolet light colony-for using ability or abnormal ultraviolet light-induced unscheduled DNA synthesis. The fibroblast strains from all the patients had markedly decreased post-ultraviolet light colony-forming ability in comparison with fibroblasts from control donors. Since this increased ultraviolet light sensitivity is propagable in vitro, it may be a manifestation of, or be closely associated with, the inherited genetic defect of this autosomal recessive disease. However, the patients' fibroblasts had normal rates of ultraviolet light-induced unscheduled DNA synthesis. Thus, unlike the UV sensitivity of DNA excision repair-deficient xeroderma pigmentosum strains, the UV sensitivity of Cockayne's syndrome strains is not related to abnormal DNA excision repair, at least to the extent that this repair process is reflected by rates of ultraviolet light-induced unscheduled DNA synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DWARFISM
KW  - DISEASES
KW  - SKIN abnormalities
KW  - FIBROBLASTS
KW  - GROWTH disorders
KW  - GENES
N1  - Accession Number: 12541383; Andrews, Alan D. 1 Barrett, Susanna F. 1 Yoder, Frank W. 1 Robbins, Jay H. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: May78, Vol. 70 Issue 5, p237; Subject Term: DWARFISM; Subject Term: DISEASES; Subject Term: SKIN abnormalities; Subject Term: FIBROBLASTS; Subject Term: GROWTH disorders; Subject Term: GENES; Number of Pages: 3p; Document Type: Report
L3  - 10.1111/1523-1747.ep12541383
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kraemer, Kenneth H.
T1  - Photochemical and Photobiological Reviews (Book).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/05//
VL  - 70
IS  - 5
M3  - Book Review
SP  - 299
EP  - 300
SN  - 0022202X
AB  - Reviews the book "Photochemical and Photobiological Reviews," by Kendric C. Smith.
KW  - PHOTOBIOLOGY
KW  - NONFICTION
KW  - SMITH, Kendrick C.
KW  - PHOTOCHEMICAL & Photobiological Reviews (Book)
N1  - Accession Number: 12541576; Kraemer, Kenneth H. 1; Affiliation:  1: Chemistry Branch, National Cancer Institute.; Source Info: May78, Vol. 70 Issue 5, p299; Subject Term: PHOTOBIOLOGY; Subject Term: NONFICTION; Reviews & Products: PHOTOCHEMICAL & Photobiological Reviews (Book); People: SMITH, Kendrick C.; Number of Pages: 2p; Document Type: Book Review
L3  - 10.1111/1523-1747.ep12541576
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yoon Sang Cho-Chung
AU  - Bodwin, Jeffrey S.
AU  - Clair, Timothy
T1  - Cyclic AMP-Binding Proteins: Inverse Relationship with Estrogen-Receptors in Hormone-Dependent Mammary Tumor Regression.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/05/02/
VL  - 86
IS  - 1
M3  - Article
SP  - 51
EP  - 60
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Dimethylbenzanthracene-induced rat mammary carcinomas possess activities binding cyclic adenosine 3′:5′-monophosphate (cAMP) and estrogen. When dimethylbenzanthracene-induced tumors regress after ovariectomy of the host, a change in the specific binding of cAMP and estrogen occurs in the tumors. Six days after ovariectomy, cAMP binding increases 5-fold in the nuclei and 2-fold in the cytosol of tumors, while nuclear and cytoplasmic estrogen binding decreases by 80% and 50%, respectively. These changes in activities binding cAMP and estrogen are detectable within I day after ovariectomy and the changes are reversed when resumption of tumor growth is induced by the injection of 17β-estradiol. When dimethylbenzanthracene-induced tumors fail to regress after ovariectomy, the change in activities binding cAMP and estrogen does not occur. Significant increases in the cAMP level as well as in adenylate cyclase and cAMP-phosphodiesterase activities are also found in the regressing tumors. Concomitant with the increase of cAMP-binding activity is an increase in historic kinase activity in the regressing tumor. These data suggest the involvement of cAMP in the growth control of a hormone-dependent mammary tumor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAMMARY glands -- Cancer
KW  - RATS
KW  - ANATOMY
KW  - ADENOSINE
KW  - CYCLIC adenylic acid
KW  - ESTROGEN
KW  - OVARIECTOMY
KW  - TUMORS -- Growth
KW  - RATS as laboratory animals
N1  - Accession Number: 13648181; Yoon Sang Cho-Chung 1 Bodwin, Jeffrey S. 1 Clair, Timothy 1; Affiliation:  1: Laboratory of Pathophysiology, National Cancer Institute, National Institute of Health, Bethesda, Maryland; Source Info: 5/2/78, Vol. 86 Issue 1, p51; Subject Term: MAMMARY glands -- Cancer; Subject Term: RATS; Subject Term: ANATOMY; Subject Term: ADENOSINE; Subject Term: CYCLIC adenylic acid; Subject Term: ESTROGEN; Subject Term: OVARIECTOMY; Subject Term: TUMORS -- Growth; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - COSTA, JONATHAN L.
AU  - JOY, DAVID C.
AU  - MAHER, DENNIS M.
AU  - KIRK, KENNETH L.
AU  - HUI, S. W.
T1  - Fluorinated Molecule as a Tracer: Difluoroserotonin in Human Platelets Mapped by Electron Energy-Loss Spectroscopy.
JO  - Science
JF  - Science
Y1  - 1978/05/05/
VL  - 200
IS  - 4341
M3  - Article
SP  - 537
EP  - 539
SN  - 00368075
AB  - The intracellular distribution of fluorine has been delineated in human platelets incubated with 4,6-difluoroserotonin, utilizing a scanning-transmission electron microscope equipped with an energy-loss spectrometer. Discrete intracellular structures corresponding in location to dense bodies contained high concentrations of fluorine. Electron energy-loss spectroscopy, which apparently can detect less than 10-20 gram of fluorine in an area of 10 square nanometers, can thus localize fluorinated tracer molecules with biological activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546550; COSTA, JONATHAN L. 1; JOY, DAVID C. 2; MAHER, DENNIS M. 2; KIRK, KENNETH L. 3; HUI, S. W. 4; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Bell Laboratories, Murray Hill, New Jersey 07974; 3: Laboratory ofChemistry, National Institute ofArthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; 4: Department ofBiophysics, Roswell Park Memorial Institute, Buffalo, New York 14263; Issue Info: 5/5/1978, Vol. 200 Issue 4341, p537; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SHICHI, HITOSHI
AU  - GAASTERLAND, DOUGLAS E.
AU  - JENSEN, NANCY M.
AU  - NEBERT, DANIEL W.
T1  - Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen.
JO  - Science
JF  - Science
Y1  - 1978/05/05/
VL  - 200
IS  - 4341
M3  - Article
SP  - 539
EP  - 541
SN  - 00368075
AB  - The Ahb/Ahb homozygous and the Ahb/Ahd heterozygous inbred mouse strains from the (C57BL/6)(DBA/2)F1 x DBA/2 backcross are genetically responsive to 3-methylcholanthrene. They both also develop, within 6 hours after a large intraperitoneal dose of acetaminophen, an irreversible opacity in the anterior portion of the lens. Such cataract formation does not occur in similarly treated nonresponsive inbred strains or nonresponsive Ahd/Ahd individuals from the same backcross. Differences in acetaminophen metabolism and toxicity are associated with the Ah locus in the mouse, and differences in heritability at the Ah locus exist in the human. Our ophthalmologic findings may be important clinically to certain patients receiving either a single large overdose of this drug or high doses over a long period. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546590; SHICHI, HITOSHI 1; GAASTERLAND, DOUGLAS E. 2; JENSEN, NANCY M. 3; NEBERT, DANIEL W. 3; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 2: Clinical Branch, National Eye Institute; 3: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 5/5/1978, Vol. 200 Issue 4341, p539; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MACDONALD, ROBERT L.
AU  - BARKER, JEFFERY L.
T1  - Different Actions of Anticonvulsant and Anesthetic Barbiturates Revealed by Use of Cultured Mammalian Neurons.
JO  - Science
JF  - Science
Y1  - 1978/05/19/
VL  - 200
IS  - 4343
M3  - Article
SP  - 775
EP  - 777
SN  - 00368075
AB  - Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the γ-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519322; MACDONALD, ROBERT L. 1; BARKER, JEFFERY L. 2; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20014, and Department of Neurology, University of Virginia, Charlottesville 22903; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; Issue Info: 5/19/1978, Vol. 200 Issue 4343, p775; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Moment, Gairdner
T1  - Author's Reply.
JO  - BioScience
JF  - BioScience
Y1  - 1978/06//
VL  - 28
IS  - 6
M3  - Letter
SP  - 364
EP  - 364
SN  - 00063568
AB  - A response by Gairdner B. Moment to two letters to the editor about his editorial "Roots and the Biologist," concerning author Alex Haley's concept of ancestry in his book "Roots," in the September 1977 issue is presented.
KW  - Letters to the editor
KW  - Genealogy
N1  - Accession Number: 28050665; Moment, Gairdner 1; Affiliations: 1 : Gerontology Research Center, National Institute on Aging, Bethesda, MD 20014;  Source Info: Jun1978, Vol. 28 Issue 6, p364; Subject Term: Letters to the editor; Subject Term: Genealogy; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 590
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Katz, P.
AU  - Fauci, A. S.
T1  - Inhibition of polyclonal B-cell activation by suppressor monocytes in patients with sarcoidosis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/06//
VL  - 32
IS  - 3
M3  - Article
SP  - 554
EP  - 562
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The present study employed a direct plaque-forming cell (PFC) assay following pokeweed mitogen (PWM) induced polyclonal activation of B lymphocytes in sarcoidosis to evaluate the in vitro humoral immune response in this disease and to delineate the immunoregulation of this response. Sarcoidosis lymphocytes had a suppressed PFC response to polyclonal activation. but were unable to suppress normal B-cell PFC responses in allogeneic co-cultures. Removal of a cell type, which was corticosteroid-resistant, radio-resistant, adherent and a non-T cell, from sarcoidosis mononuclear cell suspensions reversed the suppressed PFC response, indicating the presence of a suppressor monocyte. Thus in vitro suppressor cell activity has now been demonstrated in this disease, which is characterized by multiple immunological aberrancies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SARCOIDOSIS
KW  - B cells
KW  - MONOCYTES
KW  - LYMPHOPROLIFERATIVE disorders
KW  - PSEUDOTUBERCULOSIS
KW  - PATIENTS
N1  - Accession Number: 16288679; Katz, P. 1 Fauci, A. S. 1; Affiliation:  1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jun1978, Vol. 32 Issue 3, p554; Subject Term: SARCOIDOSIS; Subject Term: B cells; Subject Term: MONOCYTES; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: PSEUDOTUBERCULOSIS; Subject Term: PATIENTS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 83992750
T1  - Long-term anatomic fate of coronary-artery bypass grafts and functional status of patients five years after operation.
AU  - Seides, Stuart F.
AU  - Borer, Jeffrey S.
AU  - Kent, Kenneth M.
AU  - Rosing, Douglas R.
AU  - McIntosh, Charles L.
AU  - Epstein, Stephen E.
AU  - Seides, S F
AU  - Borer, J S
AU  - Kent, K M
AU  - Rosing, D R
AU  - McIntosh, C L
AU  - Epstein, S E
Y1  - 1978/06//6/ 1/1978
N1  - Accession Number: 83992750. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Functional Living Index: Cancer (FLIC) (Schipper et al). NLM UID: 0255562. 
KW  - Coronary Artery Bypass
KW  - Angina Pectoris
KW  - Coronary Disease
KW  - Coronary Angiography
KW  - Prospective Studies
KW  - Time Factors
KW  - Recurrence
KW  - Postoperative Complications
KW  - Clinical Assessment Tools
SP  - 1213
EP  - 1217
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 298
IS  - 22
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - To assess long-term results, coronary and graft angiography was performed 53 to 84 months after operation in 22 of 30 consecutive patients who had undergone coronary-artery bypass grafting before 1973, and who had at least one graft patent at an early (three to nine months) postoperative study. Of the 33 grafts, 31 were patent at late study. All patients had severe symptoms before operation. Of 16 who became asymptomatic early after operation, angina pectoris later redeveloped in 11. Progression of disease in ungrafted vessels accounted for symptomatic deterioration in nine of these 11 patients. We conclude that most grafts patent several months after operation remain so for at least 4 1/2 years, and that although most patients improve symptomatically after operation, symptomatic deterioration is common in the succeeding years and is most often due to progression of disease in ungrafted vessels.
SN  - 0028-4793
AD  - From the Cardiology and Surgery Branches, National Heart, Lung, and Blood Institute (address reprint requests to Dr. Seides at the Cardiology Branch, Bldg. 10, Rm. 7B–15, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20014).
U2  - PMID: 306575.
DO  - 10.1056/NEJM197806012982201
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Busis, NEIL A.
AU  - WEIGHT, FORREST F.
AU  - SMITH, PETER A.
T1  - Synaptic Potentials in Sympathetic Ganglia: Are They Mediated by Cyclic Nucleotides.
JO  - Science
JF  - Science
Y1  - 1978/06/02/
VL  - 200
IS  - 4345
M3  - Article
SP  - 1079
EP  - 1081
SN  - 00368075
AB  - Abstract. The hypothesis that cyclic nucleotides are intracellular second messengers mediating the generation of synaptic potentials was studied in the sympathetic ganglia of the bullfrog. Synaptic potentials and the effect of administering cyclic nucleotides and agents which affect cyclic nucleotide metabolism were recorded by the sucrose gap technique. The administration of adenosine 3',5'-monophosphate (cyclic AMP), guanosine 3',5'-monophosphate (cyclic GMP), or several of their derivatives produced little or no change in membrane potential. Prostaglandin E1 did not block the generation of postsynaptic potentials. Theophylline produced membrane effects that were different from those associated with postsynaptic potential generation; it also reduced the slow excitatory postsynaptic potential (EPSP) and potentiated the slow inhibitory postsynaptic potential (IPSP). The administration of papaverine, however, reduced both the slow EPSP and the slow IPSP. Although synaptic stimulation increases both cyclic GMP and cyclic AMP in these neurons, these results raise the possibility that these cyclic nucleotides may have functional roles other than mediation of synaptic potentials. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87477254; Busis, NEIL A. 1; WEIGHT, FORREST F. 1; SMITH, PETER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 6/2/1978, Vol. 200 Issue 4345, p1079; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - YOSHIKAMI, S.
AU  - NOLL, G. N.
T1  - Isolated Retinas Synthesize Visual Pigments from Retinol Congeners Delivered by Liposomes.
JO  - Science
JF  - Science
Y1  - 1978/06/23/
VL  - 200
IS  - 4348
M3  - Article
SP  - 1393
EP  - 1395
SN  - 00368075
AB  - Isolated vertebrate retinas bathed in circulating Ringer solution cannot regenerate all of their bleached visual pigments. When dioleoyl-lecithin vesicles containing certain retinol congeners are added to the Ringer solution, such retinas begin to regenerate pigment immediately. The visual pigment of a bleached perfused retina can now be restored fully, making the isolated retina an independent unit for study. Liposomes can protect oxygen-sensitive, lipid-solube substance and deliver them to living cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460241; YOSHIKAMI, S. 1; NOLL, G. N. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; Issue Info: 6/23/1978, Vol. 200 Issue 4348, p1393; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 83994514
T1  - Effects of coronary-artery bypass on global and regional left ventricular function during exercise.
AU  - Kent, Kenneth M.
AU  - Borer, Jeffry S.
AU  - Green, M. V.
AU  - Bacharach, Stephen L.
AU  - McIntosh, C. L.
AU  - Conkle, D. M.
AU  - Epstein, Stephen E.
AU  - Kent, K M
AU  - Borer, J S
AU  - Bacharach, S L
AU  - Epstein, S E
Y1  - 1978/06/29/
N1  - Accession Number: 83994514. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Exercise of Self-Care Agency Scale (ESCA) (Kearney and Fleischer); Global Assessment of Functioning Scale (GAF); Defining Issues Test (DIT) (Rest). NLM UID: 0255562. 
KW  - Coronary Artery Bypass
KW  - Exertion
KW  - Heart -- Physiology
KW  - Angina Pectoris -- Surgery
KW  - Coronary Vessels
KW  - Cineangiography
KW  - Aged
KW  - Myocardial Contraction
KW  - Coronary Disease
KW  - Female
KW  - Cardiac Output
KW  - Blood Pressure
KW  - Time Factors
KW  - Heart Rate
KW  - Technetium
KW  - Adult
KW  - Male
KW  - Radionuclide Imaging
KW  - Coronary Angiography
KW  - Middle Age
KW  - Electrocardiography
KW  - Exercise of Self-Care Agency Scale
KW  - Scales
SP  - 1434
EP  - 1439
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 298
IS  - 26
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - To determine the effect of coronary revascularization on exercise-induced abnormalities of left ventricular-ejection fraction and regional contraction, we obtained electrocardiograph-gated 99mTc radionuclide cineangiograms before and after operation in 23 consecutive patients. At rest, their average ejection fraction remained unchanged: 51 +/- 3 versus 54 +/- 4 per cent (+/- S.E.M.). However, 17 of the patients showed improvement of ejection fraction during postoperative exercise (increase of 51 per cent). The remaining six patients had no change or a decreased ejection fraction during exercise. All patients with improved ejection fractions during exercise were symptomatically improved. No improvement of regional function occurred at rest, but improvement did occur in regions of exercise-induced dysfunction. Although coronary revascularization has little effect on left ventricular function at rest, the ejection fraction during exercise and exercise-induced wall-motion abnormalities improve in most patients who experience symptomatic improvement.
SN  - 0028-4793
AD  - From the Cardiology Branch, National Heart, Lung, and Blood Institute, and the Nuclear Medicine Department, Clinical Center, National Institutes of Health (address reprint requests to Dr. Kent, Head, Section on Cardiovascular Diagnosis, Cardiology Branch, Bldg. 10, Room 7B–15, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20014).
U2  - PMID: 306578.
DO  - 10.1056/NEJM197806292982602
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - STEINERT, PETER
AU  - YUSPA, STUART H.
T1  - Biochemical Evidence for Keratinization by Mouse Epidermal Cells in Culture.
JO  - Science
JF  - Science
Y1  - 1978/06/30/
VL  - 200
IS  - 4349
M3  - Article
SP  - 1491
EP  - 1493
SN  - 00368075
AB  - More than 70 percent of the urea-extractable proteins from mouse stratum corneum or from differentiated cells of mouse epidermis grown in culture are two proteins of molecular weight 68,000 (keratin 1) and 60,000 (keratin 2), which are present in equimolar amounts on polyacrylamide gels. These proteins are the subunits of the keratin filaments, because when isolated from stratum corneum or cells grown in culture they form native-type epidermal keratin filaments in vitro. These observations provide biochemical evidence that epidermal cells grown in culture synthesize the major differentiation products of the epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460279; STEINERT, PETER 1; YUSPA, STUART H. 2; Affiliations: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Experimental Pathology Branch, National Cancer Institute; Issue Info: 6/30/1978, Vol. 200 Issue 4349, p1491; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ottesen, E. A.
AU  - Hiatt, R. A.
AU  - Cheever, A. W.
AU  - Sotomayor, Z. R.
AU  - Neva, F. A.
T1  - The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/07//
VL  - 33
IS  - 1
M3  - Article
SP  - 38
EP  - 47
PB  - Wiley-Blackwell
SN  - 00099104
AB  - To characterize the development and evolution of cellular immune responsiveness in individuals infected with the parasite Schistosoma mansoni, we studied fifteen patients with acute, subacute and chronic schistosumiasis. Lymphocytes from the three acutely infected patients responded vigorously to schistosome antigens in an in vitro blastogenic assay. By contrast, cells from nine chronically infected individuals were essentially unreactive to these same antigens. Patients infected for an intermediate period of time (9 months) generated responses between those of acute and chronic patients. The diminished responsiveness of chronically infected individuals was specific for schistosome antigens and did not extend to humoral immune responses. Following treatment of the infection with niridazole, these patients temporarily regained responsiveness to schistosome antigens. From these data we speculate that during the course of this parasitic helminth infection there develops a progressive and specific modulation of antigen recognition and proliferation by lymphotcytes to schistosome antigens, and that such diminished immune reactivity may be important in maintaining the unique biological relationship which exists between a host and its parasites. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SCHISTOSOMA mansoni
KW  - IMMUNE response
KW  - ANTIGENS
KW  - LYMPHOCYTES
KW  - PARASITES
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 16278326; Ottesen, E. A. 1 Hiatt, R. A. 2 Cheever, A. W. 1 Sotomayor, Z. R. 3 Neva, F. A. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA.  2: San Juan Laboratory Center for Disease Control, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.  3: Department of Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.; Source Info: Jul1978, Vol. 33 Issue 1, p38; Subject Term: SCHISTOSOMA mansoni; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: PARASITES; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kern, M.
T1  - Differentiation of lymphoid cells: Evidence for a B-cell specific serum suppressor.
JO  - Immunology
JF  - Immunology
Y1  - 1978/07//
VL  - 35
IS  - 1
M3  - Article
SP  - 57
EP  - 61
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The induction of immunoglobulin production by rabbit spleen cells is markedly inhibited by the presence of normal rabbit serum during cell culture. A similar inhibition is observed when spleen cell populations in which T cells have been inactivated are temporarily incubated with normal rabbit serum before being reconstituted with T cells by adding thymocytes. In contrast, no inhibition was observed upon temporary incubation of thymocytes with normal serum prior to addition of T cell-inactivated spleen cell populations. Removal of adherent cells did not affect the induction of immunoglobulin production or its inhibition by normal serum. Lipopolysaccharide-enhanced immunoglobulin production was also inhibited by normal serum, thereby providing additional confidence that bone-marrow derived (B) cells are the target of the normal serum inhibitor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOID tissue
KW  - BLOOD plasma
KW  - SERUM
KW  - LYMPHOCYTES
KW  - T cells
KW  - CYTOLOGY
KW  - CELL proliferation
KW  - CELL culture
N1  - Accession Number: 13948313; Kern, M. 1; Affiliation:  1: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Jul78, Vol. 35 Issue 1, p57; Subject Term: LYMPHOID tissue; Subject Term: BLOOD plasma; Subject Term: SERUM; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: CYTOLOGY; Subject Term: CELL proliferation; Subject Term: CELL culture; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donnelly, Edward F.
AU  - Murphy, Dennis L.
AU  - Goodwin, Frederick K.
T1  - PRIMARY AFFECTIVE DISORDER: ANXIETY IN TJNIPOLAR AND BIPOLAR DEPRESSED GROUPS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1978/07//
VL  - 34
IS  - 3
M3  - Article
SP  - 621
EP  - 623
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article focuses on anxiety in unipolar and bipolar depressed groups. Current research with the Minnesota Multiphasic Personality Inventory shows that the unipolar group reports more symptoms of depression and related psychopathology than the bipolar depressed group. The 29 bipolar and 21 unipolar patients studied were all severely depressed at the time of hospitalization at the Clinical Center, National Institute of Mental Health, Bethesda, Maryland. Diagnoses were made on the basis of psychiatric interviews with patients and their immediate family, as well as reports from other hospitals.
KW  - MENTAL depression
KW  - BIPOLAR disorder
KW  - MINNESOTA Multiphasic Personality Inventory
KW  - AFFECTIVE disorders
KW  - PERSONALITY tests
KW  - MARYLAND
N1  - Accession Number: 15858012; Donnelly, Edward F. 1 Murphy, Dennis L. 2 Goodwin, Frederick K. 2; Affiliation:  1: National Institute of Mental Health, Washington, D. C.  2: National Institute of Mental Health, Bethesda, Maryland.; Source Info: Jul1978, Vol. 34 Issue 3, p621; Subject Term: MENTAL depression; Subject Term: BIPOLAR disorder; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: AFFECTIVE disorders; Subject Term: PERSONALITY tests; Subject Term: MARYLAND; Number of Pages: 3p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Kleinman, Hynda K.
AU  - Murray, J. Clifford
AU  - Mcgoodwin, Ermona B.
AU  - Martin, George R.
T1  - Connective Tissue Structure: Cell Binding To Collagen.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/07//
VL  - 71
IS  - 1
M3  - Article
SP  - 9
EP  - 11
SN  - 0022202X
AB  - Established lines of fibroblasts have been shown to adhere to collagen substrates via a serum-derived glycoprotein. The attachment of various other cells to collagen types I-IV is examined here. Cells such as human skin fibroblasts, periosteum, hepatocytes, connective tissue cells, and monocytes required the serum glycoprotein and adhered equally well to all collagens, but attachment of chondrocytes, epidermal cells, and neutrophils was inhibited by the serum glycoprotein. Attachment of 2 tumorigenic cells, an osteosarcoma and a fibrosarcoma, was found to be unaffected by the serum glycoprotein. In addition, the fibrosarcoma and epidermal cells attached preferentially to type IV (basement membrane) collagen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FIBROBLASTS
KW  - CONNECTIVE tissue cells
KW  - COLLAGEN
KW  - SERUM
KW  - GLYCOPROTEINS
KW  - LIVER cells
KW  - CARTILAGE cells
N1  - Accession Number: 12543641; Kleinman, Hynda K. 1 Murray, J. Clifford 1 Mcgoodwin, Ermona B. 1 Martin, George R. 1; Affiliation:  1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul78, Vol. 71 Issue 1, p9; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; Subject Term: COLLAGEN; Subject Term: SERUM; Subject Term: GLYCOPROTEINS; Subject Term: LIVER cells; Subject Term: CARTILAGE cells; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543641
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stingl, Georg
AU  - Katz, Stephen I.
AU  - Shevach, Ethan M.
AU  - Rosenthal, Alan S.
AU  - Green, Ira
T1  - Analogous Functions of Macrophages and Langerhans Cells in the Initiation of the Immune Response.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/07//
VL  - 71
IS  - 1
M3  - Article
SP  - 59
EP  - 64
SN  - 0022202X
AB  - Langerhans cells constitute a minor cell population within the mammalian epidermis. This paper defines these cells immunologically and functionally and supports the concept that Langerhans cells are closely related to cells from the monocyte-macrophage-histiocyte series. Both cell types bear surface receptors for Fc-IgG and C3 and express surface glycoproteins, termed Ia antigens, encoded for by immune-response genes (Ir genes) of the major histocompatibility complex of the species. The expression of Ia antigens by Langerhans cells and macrophages is intimately associated with important functions of both cell types, including the capacity to present immunologically relevant antigen to the T lymphocyte and to cause proliferation to allogeneic T lymphocytes in mixed leukocyte reactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - MACROPHAGES
KW  - CELL populations
KW  - IMMUNE response
KW  - EPIDERMIS
KW  - CELL receptors
N1  - Accession Number: 12544055; Stingl, Georg 1 Katz, Stephen I. 1 Shevach, Ethan M. 1 Rosenthal, Alan S. 1 Green, Ira 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, the Laboratory of Immunology and the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul78, Vol. 71 Issue 1, p59; Subject Term: LANGERHANS cells; Subject Term: MACROPHAGES; Subject Term: CELL populations; Subject Term: IMMUNE response; Subject Term: EPIDERMIS; Subject Term: CELL receptors; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12544055
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Katz, Stephen I.
T1  - Recruitment of Basophils in Delayed Hypersensitivity Reactions.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/07//
VL  - 71
IS  - 1
M3  - Article
SP  - 70
EP  - 75
SN  - 0022202X
AB  - Basophilic leukocytes constitute a significant proportion of the cellular infiltrates in many forms of delayed-in-onset hypersensitivity reactions in human beings, guinea pigs, and other animals. In this paper, I review current information on the role of basophils in the reactions, and present similarities and differences between Jones-Mote and classic delayed hypersensitivities. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASOPHILS
KW  - ALLERGY
KW  - LEUCOCYTES
KW  - GRANULOCYTES
KW  - IMMUNOLOGIC diseases
KW  - KILLER cells
N1  - Accession Number: 12544415; Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul78, Vol. 71 Issue 1, p70; Subject Term: BASOPHILS; Subject Term: ALLERGY; Subject Term: LEUCOCYTES; Subject Term: GRANULOCYTES; Subject Term: IMMUNOLOGIC diseases; Subject Term: KILLER cells; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12544415
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Glasgow, Allen M.
AU  - Kraegel, John H.
AU  - Schulman, Joseph D.
T1  - Studies of the Cause and Treatment of Hyperammonemia in Females With Ornithine Transcarbamylase Deficiency.
JO  - Pediatrics
JF  - Pediatrics
Y1  - 1978/07//
VL  - 62
IS  - 1
M3  - Article
SP  - 30
EP  - 37
PB  - American Academy of Pediatrics
SN  - 00314005
AB  - Assay of ornithine transcarbamylase (OTC) activity in multiple small bits of liver (approximately 5 mg) that were obtained from a single surgical biopsy in a patient with OTC deficiency revealed a 10- to 40-fold variation in enzyme activity. Similar studies with control autopsy liver specimens varied 2.5-fold at most. The greater variation in the patient with OTC deficiency probably is due to sampling of clusters of normal or abnormal hepatocytes that resulted from inactivation of either the abnormal or normal X chromosome. Enzyme activity assayed on small liver biopsy specimens may not be representative of the entire liver in female patients with OTC deficiency. The hyperammonemia in individuals heterozygous for OTC deficiency may be due in part to shunting of bloods through multiple "metabolic portosystemic shunts." Treatment of a girl who has OTC deficiency with a low-protein diet, a low-protein diet supplemented with oral essential amino acids, and a low-protein diet plus oral ketoacids of essential amino acids was compared in short-term balance studies; on a separate occasion, a low-protein diet was compared to a low-protein diet plus lactulose. The low-protein diet plus oral ketoacid supplementation resulted in the best metabolic control of the patient's disease. On the other hand, paradoxical transient hyperammonemia was observed after the intravenous administration of ketoacids to two acutely ill female patients with OTC deficiency. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ORNITHINE carbamoyltransferase deficiency
KW  - X chromosome
KW  - KETONIC acids
KW  - LACTULOSE
KW  - LIVER cells
KW  - ENZYMES
KW  - WOMEN -- Health
N1  - Accession Number: 32085856; Glasgow, Allen M. 1,2 Kraegel, John H. 1,2 Schulman, Joseph D. 1,2; Affiliation:  1: Department of Endocrinology and Metabolism, Children's Hospital National Medical Center  2: Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Jul78, Vol. 62 Issue 1, p30; Subject Term: ORNITHINE carbamoyltransferase deficiency; Subject Term: X chromosome; Subject Term: KETONIC acids; Subject Term: LACTULOSE; Subject Term: LIVER cells; Subject Term: ENZYMES; Subject Term: WOMEN -- Health; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Poulsen, S.
AU  - Larson, R. H.
AU  - Senning, R. S.
T1  - Effect of dextranase on plaque formation and caries development in the rat.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1978/07//
VL  - 86
IS  - 4
M3  - Article
SP  - 231
EP  - 236
SN  - 0029845X
AB  - Plaque formation and caries development were studied in 0-M rats fed Diet 2000 and infected with <em>S. mutans</em> 6715 and fecal flora from older caries-active rats. Merck dextranase, Beckman dextranase or Beckman glucanase 447 were administered singly or in combination to groups of 12 rats either as an addition to the diet or as a "mouthwash" twice daily, 5 d per week. All enzymes studied were associated with significant inhibition of both plaque formation and caries development, especially on the buccal and lingual surfaces. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEXTRANASE
KW  - DENTAL plaque
KW  - DENTAL caries
KW  - RATS
KW  - DIET
KW  - GLYCOSIDASES
KW  - <em>dental caries</em>
KW  - <em>dental plaque</em>
KW  - <em>dextranase</em>
KW  - <em>rat</em>
N1  - Accession Number: 13241120; Poulsen, S. 1 Larson, R. H. 1 Senning, R. S. 1; Affiliation:  1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jul1978, Vol. 86 Issue 4, p231; Subject Term: DEXTRANASE; Subject Term: DENTAL plaque; Subject Term: DENTAL caries; Subject Term: RATS; Subject Term: DIET; Subject Term: GLYCOSIDASES; Author-Supplied Keyword: <em>dental caries</em>; Author-Supplied Keyword: <em>dental plaque</em>; Author-Supplied Keyword: <em>dextranase</em>; Author-Supplied Keyword: <em>rat</em>; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gordon, James S.
T1  - Group homes: alternative to institutions.
JO  - Social Work
JF  - Social Work
Y1  - 1978/07//
VL  - 23
IS  - 4
M3  - Article
SP  - 300
PB  - Oxford University Press / USA
SN  - 00378046
AB  - The article deals with a study which considered group homes as an alternative form of residential care for adolescents in the U.S. Over 100,000 adolescents are hospitalized for mental illness each year. Many of these young people could successfully grow to adulthood in a collectively run household rather than as patients in a hospital or residential treatment center. These young people had been referred for institutionalization or continued institutionalization at the time of their entry into the home, which is referred to as Frye House in this article. Frye House was opened in 1970 by the staff of a nearby house for run-away teenagers that was designed to provide long-term residential care for young people who were unable to live with their parents despite individual and family counseling. It was one of a number of projects, including a high school and a job-finding service, that were linked to the house for runaways in a collectively run youth services program. Its founders were nonprofessionals who had been active in the civil rights and antiwar movements of the 1960s. Although they did not specifically refer to the work of others, they shared the therapeutic ideals of child guidance workers who tried to identify with the child despite his behavior.
KW  - SOCIAL institutions
KW  - TEENAGERS -- Services for
KW  - SOCIAL services
KW  - PARENT & teenager
KW  - THERAPEUTICS
KW  - UNITED States
N1  - Accession Number: 5274514; Gordon, James S. 1; Affiliation:  1: Research Psychiatrist, Center for Studies of Child and Family Mental Health, National Institute of Mental Health, Rockville, Maryland.; Source Info: Jul78, Vol. 23 Issue 4, p300; Subject Term: SOCIAL institutions; Subject Term: TEENAGERS -- Services for; Subject Term: SOCIAL services; Subject Term: PARENT & teenager; Subject Term: THERAPEUTICS; Subject Term: UNITED States; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-43088-007
AN  - 2013-43088-007
AU  - Goebes, Diane D.
AU  - Shore, Milton F.
T1  - Some effects of bicultural and monocultural school environments on personality development.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1978/07//
VL  - 48
IS  - 3
SP  - 398
EP  - 407
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Mental Health Study Center, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-43088-007. PMID: 677276 Partial author list: First Author & Affiliation: Goebes, Diane D.; Catholic University of America, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Classroom Behavior Modification; Personality Development; Role Taking; School Environment; Self-Concept. Minor Descriptor: Cross Cultural Differences; Human Females. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1978. 
AB  - Preadolescent girls in a bicultural school, compared with those in a mono-cultural school, showed more heterocultural peer-group organization, better self-image, and greater acceptance of an unknown cultural group. These differences were not found among younger (latency-age) children in the two schools. No significant differences were found in role-taking ability between girls in the two schools, suggesting that the bicultural school environment contributes to the difference in the other personality dimensions studied. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - bicultural school environment
KW  - monocultural school environment
KW  - self image
KW  - unknown cultural group
KW  - personality dimensions
KW  - role taking ability
KW  - 1978
KW  - Classroom Behavior Modification
KW  - Personality Development
KW  - Role Taking
KW  - School Environment
KW  - Self-Concept
KW  - Cross Cultural Differences
KW  - Human Females
KW  - 1978
DO  - 10.1111/j.1939-0025.1978.tb01330.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06396-019
AN  - 2006-06396-019
AU  - Smith, Jean Paul
AU  - Szara, Stephen
T1  - The Lure of Grass.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1978/07//
VL  - 23
IS  - 7
SP  - 508
EP  - 509
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06396-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Smith, Jean Paul; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Experimentation; Marijuana. Minor Descriptor: Psychopathology; Sciences. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10). Reviewed Item: Abel, Ernest L. (Ed). The Scientific Study of Marihuana=Chicago: Nelson-Hall, 1976. Pp. xviii + 299. $12.50; 1976. Page Count: 2. Issue Publication Date: Jul, 1978. 
AB  - Reviews the book, The Scientific Study of Marihuana by Ernest L. Abel (1976). Abel claims that this book contains a collection of the most recent findings in marihuana research. This claim is misleading from the reader's point of view since the latest papers included in the volume came out in 1972. This compilation gives a reasonably balanced picture of the status of scientific research on marihuana as of 1972. For those who are concerned about the effects of this drug, this book may be an adequate introduction to the various aspects of the known facts, and to the different approaches science takes to learn about them. For those who need to know more about trie medical or psychological consequences of the use of this drug, more recent updating on the state of the art is clearly necessary. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - marihuana
KW  - scientific research
KW  - sciences
KW  - 1978
KW  - Experimentation
KW  - Marijuana
KW  - Psychopathology
KW  - Sciences
KW  - 1978
U2  - Abel, Ernest L. (Ed). (1976); The Scientific Study of Marihuana; Chicago: Nelson-Hall, 1976. Pp. xviii + 299. $12.50
DO  - 10.1037/017341
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-43088-023
AN  - 2013-43088-023
AU  - Lystad, Mary
T1  - Review of The cycle of violence: Assertive, aggressive, and abusive family interaction.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1978/07//
VL  - 48
IS  - 3
SP  - 557
EP  - 559
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-43088-023. Partial author list: First Author & Affiliation: Lystad, Mary; Division of Special Mental Health Programs, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Domestic Violence; Family Relations. Minor Descriptor: Aggressiveness; Extraversion; Social Interaction; Well Being. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Location: US. Reviewed Item: Steinrnetz, Suzanne K. The cycle of violence: Assertive, aggressive, and abusive family interaction=191 pp. $16.95. Praeger, New York; 1977. Page Count: 3. Issue Publication Date: Jul, 1978. 
AB  - Reviews the book, The cycle of violence: Assertive, aggressive, and abusive family interaction by Suzanne K. Steinrnetz (see record [rid]1978-27374-000[/rid]). This book reports on the incidence and nature of violent behavior among a stratified quota sample of families in New Castle County, Delaware. As an exploratory study, the work provides valuable insights into the amount of violent behavior among some suburban/urban white households, the interrelationships of family members in violent behavior. Steinmetz asserts that what is needed on the societal level is full employment, adequate social and health benefits, and less violent television programs. Steinmetz has indeed made a contribution to understanding this critical social problem. For it is within the family that our people continue to look for love and nurture and support for this and for the next generation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - violence cycle
KW  - assertive interaction
KW  - aggressive interaction
KW  - abusive family interaction
KW  - health benefits
KW  - 1978
KW  - Domestic Violence
KW  - Family Relations
KW  - Aggressiveness
KW  - Extraversion
KW  - Social Interaction
KW  - Well Being
KW  - 1978
U2  - Steinrnetz, Suzanne K. (1977); The cycle of violence: Assertive, aggressive, and abusive family interaction; 191 pp. $16.95. Praeger, New York
DO  - 10.1037/h0099060
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Garn, Stanley M.
AU  - Shaw, Helen A.
AU  - McCabe, Kinne D.
T1  - Effect of maternal smoking on weight and weight gain between pregnancies.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1978/08//
VL  - 31
IS  - 8
M3  - Article
SP  - 1302
EP  - 1303
SN  - 00029165
N1  - Accession Number: 94357615; Garn, Stanley M. 1; Shaw, Helen A. 1; McCabe, Kinne D. 2; Affiliations: 1: Center for Human Growth and Development, The University of Michigan, Ann Arbor, Michigan 48109; 2: The Collaborative Perinatal Project, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: Aug1978, Vol. 31 Issue 8, p1302; Number of Pages: 2p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Berreman, Gerald D.
AU  - Carroll, James D.
AU  - Coser, Rose Laub
AU  - Douglas, Jack D.
AU  - Freidson, Eliot
AU  - Gray, Bradford H.
AU  - Klockars, Carl B.
AU  - Lazar, Joyce Barham
AU  - Liell, John T.
AU  - Pattullo, E. L.
AU  - Schulman, Jay
AU  - Vaughan, Ted R.
AU  - Sjoberg, Gideon
T1  - COMMENTS.
JO  - American Sociologist
JF  - American Sociologist
Y1  - 1978/08//
VL  - 13
IS  - 3
M3  - Article
SP  - 153
EP  - 172
SN  - 00031232
AB  - The section presents comments on articles featured in the August 1978 issue of The American Sociologist.  Gerald D. Berreman claims that the ethics and responsibility in social science research are frustrating to discuss in print or in person: the issues are complex and highly contextual so that clear-cut rules-of-thumb are impossible to formulate; they are value-laden and controversial so that discussion often degenerates into preachment, accusation and defense.  James D. Carroll noted that each of the articles is a useful contribution to the understanding of law, politics and administration of knowledge.  From an analytical perspective, these papers fit well into conceptual frameworks suggested by such terms as "post-industrial society," "knowledge society," and the like.  From a professional perspective, each of the papers addresses issues that researchers should be more familiar with, and that professional societies should have greater capacity to address on a systematic basis than is presently the case.  From a legal perspective, the paper by Kathleen Bond addresses a constitutional question under the U.S. first amendment, which involves something of a paradox.  Carl B. Klockars suggests a model of sociological research that begs the softening of a series of trained incapacities, which the sociological community has worked long and hard against substantial resistance to develop.
KW  - SOCIAL science research
KW  - SOCIOLOGICAL research
KW  - LAW -- Political aspects
KW  - RESEARCH
KW  - SERIAL publications
N1  - Accession Number: 4946168; Berreman, Gerald D. 1 Carroll, James D. 2 Coser, Rose Laub 3 Douglas, Jack D. 4 Freidson, Eliot 5 Gray, Bradford H. 6 Klockars, Carl B. 7 Lazar, Joyce Barham 8 Liell, John T. 9 Pattullo, E. L. 10 Schulman, Jay 11 Vaughan, Ted R. 12 Sjoberg, Gideon 13; Affiliation:  1: Dept. of Anthropology, University of California, Berkeley, CA 94720  2: Maxwell School of Public Administration, Syracuse University, Syracuse, NY 13210  3: Health Science Center, State University of New York, Stony Brook, NY 11794  4: Dept. of Sociology, University of California, San Diego, La Jolla, CA 92093  5: Dept. of Sociology, New York University, New York, NY 1003  6: Institute of Medicine, National Academy of Sciences, 2101 Constitution Ave., Washington, D.C. 20418  7: Dept. of Sociology, University of Delaware, Newark, DL 19711  8: National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD 20857  9: Dept. of Sociology, Indiana University, Indianapolis, 925 W. Michigan, Indianapolis, IN 46202  10: Center for the Behavioral Sciences, William James Hall Harvard University, Cambridge, MA 02138  11: National Jury Project, 853 Broadway, rm. 2022, New York, NY 10001  12: Dept. of Sociology, Univ. of Missouri, Columbia, MO 65201  13: Dept. of Sociology, Univ. of Texas, Austin, TX 78712; Source Info: Aug78, Vol. 13 Issue 3, p153; Subject Term: SOCIAL science research; Subject Term: SOCIOLOGICAL research; Subject Term: LAW -- Political aspects; Subject Term: RESEARCH; Subject Term: SERIAL publications; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 29p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Alexander, E. L.
AU  - Henkart, P. A.
T1  - Human peripheral lymphocytes bearing surface immunoglobulin do not have readily detectable Fc receptors.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/08//
VL  - 33
IS  - 2
M3  - Article
SP  - 332
EP  - 339
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The question of whether human peripheral B lymphocytes have Fc receptors was examined directly by double-label immunofluorescent techniques utilizing assays for detection of Fc receptors, surface immunoglobulin, and complement receptors. Fc receptors were detected by indirect immunofluorescence after incubation with soluble antigen-antibody complexes. Complement receptors were detected by the binding of fluoresceinated bacteria coated with complement. It was demonstrated that most surface immunoglobulin-bearing, complement-receptor positive lymphocytes did not bind soluble antigen-antibody complexes. Conversely, most cells which readily bound soluble complexes did not have surface immunoglobulin or complement receptors. Therefore, most peripheral B lymphocytes do not have easily detectable Fc receptors and most Fc receptor-bearing lymphocytes do not have B cell markers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - IMMUNOGLOBULINS
KW  - B cells
KW  - CELL receptors
KW  - MACROPHAGES
KW  - IMMUNOCYTOCHEMISTRY
KW  - IMMUNOFLUORESCENCE
N1  - Accession Number: 16111359; Alexander, E. L. 1 Henkart, P. A. 1; Affiliation:  1: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 USA; Source Info: Aug1978, Vol. 33 Issue 2, p332; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: B cells; Subject Term: CELL receptors; Subject Term: MACROPHAGES; Subject Term: IMMUNOCYTOCHEMISTRY; Subject Term: IMMUNOFLUORESCENCE; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Greulich, Richard C.
T1  - Prolonging life span: Present and future possibilities.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1978/08//
VL  - 33
IS  - 8
M3  - Article
SP  - 88
EP  - 89
SN  - 0016867X
N1  - Accession Number: 17321097; Greulich, Richard C. 1; Source Information: Aug1978, Vol. 33 Issue 8, p88; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1109
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Hollenbeck, Albert R.
T1  - TELEVISION VIEWING PATTERNS OF FAMILIES WITH YOUNG INFANTS.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1978/08//
VL  - 105
IS  - 2
M3  - Article
SP  - 259
PB  - Taylor & Francis Ltd
SN  - 00224545
N1  - Accession Number: 5388267; Hollenbeck, Albert R. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Aug1978, Vol. 105 Issue 2, p259; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Spaner, Fred E.
AU  - Sharfstein, Steven S.
AU  - Taube, Carl A.
AU  - Bassuk, Ellen L.
AU  - Gerson, Samuel
T1  - LETTERS.
JO  - Scientific American
JF  - Scientific American
Y1  - 1978/08//
VL  - 239
IS  - 2
M3  - Letter
SP  - 8
EP  - 10
SN  - 00368733
AB  - A letter to the editor is presented in response to the article "Deinstitutionalization and Mental Health Services," by Ellen L. Bassuk and Samuel Gerson in the February 1978 issue.
KW  - Letters to the editor
KW  - Mental health services
N1  - Accession Number: 19789261; Spaner, Fred E. 1; Sharfstein, Steven S. 1; Taube, Carl A. 1; Bassuk, Ellen L. 2; Gerson, Samuel 3; Affiliations: 1: National Institute of Mental Health, Rockville, Md.; 2: Harvard Medical School, Boston; 3: Cambridge Hospital, Cambridge, Massachusetts; Issue Info: Aug78, Vol. 239 Issue 2, p8; Subject Term: Letters to the editor; Subject Term: Mental health services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Coulter, Charles L.
T1  - Research Instrument Sharing.
JO  - Science
JF  - Science
Y1  - 1978/08/04/
VL  - 201
IS  - 4354
M3  - Article
SP  - 415
EP  - 420
SN  - 00368075
N1  - Accession Number: 87461069; Coulter, Charles L. 1; Affiliations: 1: head of the Biological Structure Section, Biotechnology Resources Program, Division of Research Resources, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p415; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - RAINE, CEDRIC S.
AU  - TRAUGOTT, UTE
AU  - STONE, SANFORD H.
T1  - Suppression of Chronic Alergic Encephalomyelitis: Relevance to Multiple Sclerosis.
JO  - Science
JF  - Science
Y1  - 1978/08/04/
VL  - 201
IS  - 4354
M3  - Article
SP  - 445
EP  - 448
SN  - 00368075
AB  - The expression of chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs was suppressed with a single series of injections of myelin basic protein in incomplete Freund's adjuvant. The suppression appeared permanent, and subsequent rechallenge with central nervous sytem antigen failed to elicit exacerbations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461087; RAINE, CEDRIC S. 1; TRAUGOTT, UTE 1; STONE, SANFORD H. 2; Affiliations: 1: Departments of Pathology and Neuroscience and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461; 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p445; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ALDRICH, J. R.
AU  - BLUM, M. S.
AU  - HEFETZ, A.
AU  - FALES, H. M.
AU  - LLOYD, H. A.
AU  - ROLLER, P.
T1  - Proteins in a Nonvenomous Defensive Secretion: Biosynthetic Significance.
JO  - Science
JF  - Science
Y1  - 1978/08/04/
VL  - 201
IS  - 4354
M3  - Article
SP  - 452
EP  - 454
SN  - 00368075
AB  - In common with many arthropods, the true bug, Leptoglossus phyllopus, when disturbed, emits a two-phase secretion that consists ofan organic phase and an aqueous phase. The organic phase is a mixture of highly reactive low-molecular-weight compounds, analogous to those produced by other arthropods, and is deterrent to many kinds ofpredators. The aqueous phase, heretofore ignored in most analyses of arthropod defensive secretions, contains proteins. Even though the secretion is not injected, the proteins enzymatically catalyze the derivation of the most reactive components within the impermeable cuticular storage reservoir and, thus, constitute part of the defensive system that appears to be commonly used by arthropods producing irritating chemicals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461064; ALDRICH, J. R. 1; BLUM, M. S. 1; HEFETZ, A. 2; FALES, H. M. 2; LLOYD, H. A. 2; ROLLER, P. 2; Affiliations: 1: Department of Entomology, University of Georgia, Athens 30602; 2: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p452; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FISCHINGER, PETER J.
AU  - BLEVINS, CHARLOTTE S.
AU  - DUNLOP, NANCY M.
T1  - Genomic Masking of Nondefective Recombinant Murine Leukemia Virus in Moloney Virus Stocks.
JO  - Science
JF  - Science
Y1  - 1978/08/04/
VL  - 201
IS  - 4354
M3  - Article
SP  - 457
EP  - 459
SN  - 00368075
AB  - HIX virus clonedfrom Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis ofseveral virus stocks and the examination of virus progeny from individualfoci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461075; FISCHINGER, PETER J. 1; BLEVINS, CHARLOTTE S. 1; DUNLOP, NANCY M. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p457; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CRUIKSHANK, DALE P.
AU  - DELIsI, CHARLES
T1  - Human Rights: Visiting the Soviet Union.
JO  - Science
JF  - Science
Y1  - 1978/08/11/
VL  - 201
IS  - 4355
M3  - Article
SP  - 482
EP  - 482
SN  - 00368075
N1  - Accession Number: 87437170; CRUIKSHANK, DALE P. 1; DELIsI, CHARLES 2; Affiliations: 1: Institute for Astronomy, University of Hawaii, Honolulu 96822; 2: Laboratory of Theoretical Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/11/1978, Vol. 201 Issue 4355, p482; Number of Pages: 1/2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Rahimtula, Anver D.
AU  - O'Brien, Peter J.
AU  - Seifried, Harold E.
AU  - Jerina, Donald M.
T1  - The Mechanism of Action of Cytochrome <em>P</em>-450. Occurrence of the 'NIH Shift' during Hydroperoxide-Dependent Aromatic Hydroxylations.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/08/15/
VL  - 89
IS  - 1
M3  - Article
SP  - 133
EP  - 141
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The mechanism of liver microsomal aromatic hydroxylation has been investigated by using cumene hydroperoxide as the hydroxylating agent and comparing this reaction with the NADPH-dependent reaction. The conversion of [4-³H]acetanilide to 4-hydroxyacetanilide by rat liver microsomes (or purified cytochrome P-450) in the presence of either cumene hydroperoxide or NADPH is attended by comparable 'NIH shifts'. This indicates that hydroxylation in the two systems proceeds via a common intermediate, presumably an arene oxide. The intermediacy of an arene oxide, phenanthrene-9,10-oxide, is established by incubating [3-³H]-phenanthrene with rat-liver microsomes and cumene hydroperoxide in the presence of either nonradioactive phenanthrene-9,10-oxide as a 'trap' or in the presence of cyclohexene oxide, an inhibitor of the enzyme epoxide hydrase. Incubation of phenanthrene with cumene hydroperoxide in an 18O-enriched medium has confirmed that the oxygen atom in phenanthrene-9,10-oxide is derived from the hydroperoxide and not from the medium. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOCHROME P-450
KW  - HYDROXYLATION
KW  - BIOCHEMISTRY
KW  - CHEMICAL reactions
KW  - MONOOXYGENASES
KW  - LIVER
N1  - Accession Number: 13675093; Rahimtula, Anver D. 1 O'Brien, Peter J. 1 Seifried, Harold E. 1 Jerina, Donald M. 1; Affiliation:  1: Department of Biochemistry, Memorial University of Newfoundland, St John's, and National Institutes of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda; Source Info: 8/15/78, Vol. 89 Issue 1, p133; Subject Term: CYTOCHROME P-450; Subject Term: HYDROXYLATION; Subject Term: BIOCHEMISTRY; Subject Term: CHEMICAL reactions; Subject Term: MONOOXYGENASES; Subject Term: LIVER; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GARTLAND, JR., WILLIAM J.
T1  - Recombinant DNA Research: Proposed Revised Guidelines.
JO  - Science
JF  - Science
Y1  - 1978/08/18/
VL  - 201
IS  - 4356
M3  - Article
SP  - 572
EP  - 572
SN  - 00368075
N1  - Accession Number: 87437201; GARTLAND, JR., WILLIAM J. 1; Affiliations: 1: Office of Recombinant DNA Activities, National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 8/18/1978, Vol. 201 Issue 4356, p572; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Schall, Jos. J.
AU  - Pianka, Eric R.
T1  - Geographical Trends in Numbers of Species.
JO  - Science
JF  - Science
Y1  - 1978/08/25/
VL  - 201
IS  - 4357
M3  - Article
SP  - 679
EP  - 686
SN  - 00368075
AB  - Geographic variation in the number of coexisting plant and animal species (species density) often follows repeated patterns; best known is the general increase in species richness from temperate to tropical latitudes. Here we undertake a quantitative analysis of geographic trends in species density for the terrestrial vertebrate faunas of the United States and Australia. Trends in numbers of species of amphibians, reptiles, birds, and mammals are described and are correlated with geographic variation in abiotic environmental measures. Intercontinental comparisons reveal general patterns as well as intriguing and profound differences in vertebrate distributions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87437231; Schall, Jos. J. 1; Pianka, Eric R. 2; Affiliations: 1: National Institutes of Health research fellow, Department of Zoology, University of California; 2: professor in the Department of Zoology, University of Texas, Austin 78712.; Issue Info: 8/25/1978, Vol. 201 Issue 4357, p679; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Gage, Fred H.
AU  - Lieberman, Alicia F.
T1  - A Multivariate Analysis of Social Dominance in Children.
JO  - Aggressive Behavior
JF  - Aggressive Behavior
Y1  - 1978/09//
VL  - 4
IS  - 3
M3  - Article
SP  - 219
EP  - 229
PB  - John Wiley & Sons, Inc.
SN  - 0096140X
AB  - The social dominance behavior of dyads of unacquainted, same-sex 3½- year-olds was observed in a familiar laboratory playroom under two conditions: A free play situation and a situation where candy was introduced. In each of the two conditions, a principal components analysis was used to explore two issues: the usefulness of the multivariate approach in devising a definition of dominance, and the cross-situational stability of the construct. In the free play session, the first principal component that emerged was consistent with a theoretical definition of dominance. This picture was disrupted by the introduction of candy in the second condition. However, a high correlation was found between the dominance hierarchies established in each situation. It was concluded that the multivariate analysis is a useful method for the study of dominance. The generalizability of social dominance across settings was discussed as a possible explanation for the high cross-situational stability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Aggressive Behavior is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DOMINANCE (Psychology)
KW  - CHILD psychology
KW  - PLAYROOMS
KW  - PRINCIPAL components analysis
KW  - MULTIVARIATE analysis
KW  - SOCIAL psychology
KW  - children
KW  - multivariate analysis.
KW  - social dominance
N1  - Accession Number: 11989308; Gage, Fred H. 1 Lieberman, Alicia F. 2; Affiliation:  1: Department of Psychology, Texas Christian University, Fort Worth (F. H. G.)  2: Mental Health Study Center, National institute of Mental Health, .Adelphi, Maryland (A.F.L.); Source Info: 1978, Vol. 4 Issue 3, p219; Subject Term: DOMINANCE (Psychology); Subject Term: CHILD psychology; Subject Term: PLAYROOMS; Subject Term: PRINCIPAL components analysis; Subject Term: MULTIVARIATE analysis; Subject Term: SOCIAL psychology; Author-Supplied Keyword: children; Author-Supplied Keyword: multivariate analysis.; Author-Supplied Keyword: social dominance; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kannel, William B.
AU  - Wolf, Philip
AU  - Dawber, Thomas R.
T1  - Hypertension and cardiac impairments increase stroke risk.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1978/09//
VL  - 33
IS  - 9
M3  - Article
SP  - 71
EP  - 83
SN  - 0016867X
N1  - Accession Number: 17308587; Kannel, William B. 1; Wolf, Philip 2; Dawber, Thomas R. 3; Source Information: Sep1978, Vol. 33 Issue 9, p71; Number of Pages: 10p; Illustrations: 9 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 4738
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Yaoita, Hideo
T1  - Identification of IgA Binding Structures in Skin of Patients with Dermatitis Herpetiformis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1978/09//
VL  - 71
IS  - 3
M3  - Article
SP  - 213
EP  - 216
SN  - 0022202X
AB  - Immunoelectronmicroscopic and ultrastructural identification of the structures which bind IgA in skin of patients with dermatitis herpetiformis (DH) reveals them to be, in part, a complex of fibrillar components which are covered with amorphous substances. One of the fibers has a diameter of 80-130 Å and appears to be tubular, resembling dermal microfibrillar bundles or microtubular elements of elastic fibers. The structures, at times, are associated with the dermal microfibrillar bundles and are found within an elastic fiber system which is in close proximity to the dermal-epidermal junction. Taken together, these findings suggest that the structures which bind IgA are unique to DH and might be a part of an abnormal dermal microfibrillar bundleelastic fiber system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ELECTRON microscopy -- Technique
KW  - DERMATITIS herpetiformis
KW  - AMORPHOUS substances
KW  - MICROFIBRILS
KW  - MICROTUBULES
KW  - SKIN -- Inflammation
N1  - Accession Number: 12547280; Yaoita, Hideo 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep78, Vol. 71 Issue 3, p213; Subject Term: ELECTRON microscopy -- Technique; Subject Term: DERMATITIS herpetiformis; Subject Term: AMORPHOUS substances; Subject Term: MICROFIBRILS; Subject Term: MICROTUBULES; Subject Term: SKIN -- Inflammation; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12547280
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schruben, Lee W.
AU  - Margolin, Barry H.
T1  - Pseudorandom Number Assignment in Statistically Designed Simulation and Distribution Sampling Experiments.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1978/09//
VL  - 73
IS  - 363
M3  - Article
SP  - 504
SN  - 01621459
AB  - This research investigates various strategies for assigning pseudorandom numbers to experimental points in statistically designed simulation and distribution sampling experiments. Strategies studied include the widely advocated practices of (i) employing a common set of pseudorandom numbers for all experimental points, and (ii) assigning a unique set of pseudorandom numbers to each experimental point. An alternative, based upon blocking concepts in designed experiments, is devised and shown to improve upon existing recommendations for a wide class of problems. A small simulation, a pilot study of a hospital resource allocation problem, illustrates the new strategy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SAMPLING (Statistics)
KW  - MONTE Carlo method
KW  - ANALYSIS of variance
KW  - TIME series analysis
KW  - SIMULATION methods & models
KW  - DISTRIBUTION (Probability theory)
KW  - Designed experiments
KW  - Distribution sampling
KW  - Monte Carlo
KW  - Simulation
KW  - Time series analysis
KW  - Variance reduction techniques.
N1  - Accession Number: 4601225; Schruben, Lee W. 1; Margolin, Barry H. 2; Affiliations: 1: Assistant Professor, Department of Operations Research, Cornell University, Ithaca, NY 14850.; 2: Mathematical Statistician, National Institute of Environmental Health Sciences, Biometry Branch, Research Triangle Park, NC 27709.; Issue Info: Sep78, Vol. 73 Issue 363, p504; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MONTE Carlo method; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: TIME series analysis; Thesaurus Term: SIMULATION methods & models; Thesaurus Term: DISTRIBUTION (Probability theory); Author-Supplied Keyword: Designed experiments; Author-Supplied Keyword: Distribution sampling; Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: Simulation; Author-Supplied Keyword: Time series analysis; Author-Supplied Keyword: Variance reduction techniques.; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - RAPP, ULF R.
AU  - TODARO, GEORGE J.
T1  - Generation of New Mouse Sarcoma Viruses in Cell Culture.
JO  - Science
JF  - Science
Y1  - 1978/09//9/1/1978
VL  - 201
IS  - 4358
M3  - Article
SP  - 821
EP  - 824
SN  - 00368075
AB  - Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519399; RAPP, ULF R. 1; TODARO, GEORGE J. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/1/1978, Vol. 201 Issue 4358, p821; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FOX, BERNARD H.
T1  - Cancer Death Risk in Hospitalized Mental Patients.
JO  - Science
JF  - Science
Y1  - 1978/09/15/
VL  - 201
IS  - 4360
M3  - Article
SP  - 966
EP  - 968
SN  - 00368075
N1  - Accession Number: 87546608; FOX, BERNARD H. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/15/1978, Vol. 201 Issue 4360, p966; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GOLDMAN, ARNOLD I.
AU  - O'BRIEN, PAUL J.
T1  - Phagocytosis in the Retinal Pigment Epithelium of the RCS Rat.
JO  - Science
JF  - Science
Y1  - 1978/09/15/
VL  - 201
IS  - 4360
M3  - Article
SP  - 1023
EP  - 1025
SN  - 00368075
AB  - The retinal pigment epithelium of RCS rats, previously thought not to phagocytize photoreceptor outer segments, exhibited a peak of phagocytosis in vivo when animals were kept under conditions of cyclic lighting (12 hours of darkness and 12 hours of light). This peak occurred at 1 hour after the onset of light, with maximum and minimum levels of phagocytosis averaging about 5 percent of that found in the pigment epithelium of Osborn-Mendel rats used as a control. Eyecups that were obtained from Osborn-Mendel rats and maintained for up to 3 hours in organ culture demonstrated levels of phagocytosis that were sevenfold greater than those of unincubated controls. Likewise, a tenfold increase occurred in incubated as opposed to unincubated RCS eyes, raising the possibility that phagocytosis could be experimentally stimulated in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546610; GOLDMAN, ARNOLD I. 1; O'BRIEN, PAUL J. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/15/1978, Vol. 201 Issue 4360, p1023; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - AGUIRRE, G.
AU  - FARBER, D.
AU  - LOLLEY, R.
AU  - FLETCHER, R. T.
AU  - CHADER, G. J.
T1  - Rod-Cone Dysplasia in Irish Setters: A Defect in Cyclic GMP Metabolism in Visual Cells.
JO  - Science
JF  - Science
Y1  - 1978/09/22/
VL  - 201
IS  - 4361
M3  - Article
SP  - 1133
EP  - 1134
SN  - 00368075
AB  - An abnormality in retinal guanosine 3',5'-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasia of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546634; AGUIRRE, G. 1; FARBER, D. 2; LOLLEY, R. 3; FLETCHER, R. T. 4; CHADER, G. J. 4; Affiliations: 1: Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104; 2: Jules Stein Eye Institute, School of Medicine, University of California, Los Angeles 90024; 3: Developmental Neurology, Veterans Administration Hospital, Sepulveda, California 91343; 4: National Eye Institute, Bethesda, Maryland 20014; Issue Info: 9/22/1978, Vol. 201 Issue 4361, p1133; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rogot, Eugene
T1  - Smoking and Life Expectancy among U.S. Veterans.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1978/10//
VL  - 68
IS  - 10
M3  - Article
SP  - 1023
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses on medical study concerning smoking and life expectancy between veterans in the U.S. Life expectancies were estimated for selected groups of smokers, ex-smokers, and non-smokers. The researcher assessed that life expectancy varied based on the number of cigarettes smoked per day. The most notable differences in life expectancy were among non-smokers and heavy-cigarette smokers. These differences were the most superior at the younger ages, ranging 9 years at ages 35 and 40. Life expectancies for cigarette smokers differed directly with age began smoking. In general range of ages, differences in life expectancy among non-smokers and ex-cigarette smokers who stopped for other than doctor's orders were less than those between non-smokers and current cigarette smokers.
KW  - LIFE expectancy
KW  - VETERANS -- Health
KW  - CIGARETTE smokers
KW  - MEDICAL research
KW  - TOBACCO -- Physiological effect
KW  - MORTALITY
KW  - CLINICAL medicine
KW  - CASE studies
KW  - UNITED States
N1  - Accession Number: 5669492; Rogot, Eugene 1; Affiliation:  1: Epidemiology Branch, Division of Heat and Vascular Diseases, National Heart, Lung, and Blood Institute, Federal building, Room 2C08, Bethesda, MD 20014; Source Info: Oct78, Vol. 68 Issue 10, p1023; Subject Term: LIFE expectancy; Subject Term: VETERANS -- Health; Subject Term: CIGARETTE smokers; Subject Term: MEDICAL research; Subject Term: TOBACCO -- Physiological effect; Subject Term: MORTALITY; Subject Term: CLINICAL medicine; Subject Term: CASE studies; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Sitaram, N.;
AU  - Moore, A. M.;
AU  - Gillin, J. C.;
T1  - Effect of physostigmine on normal human sleep and dreaming
CT  - Effect of physostigmine on normal human sleep and dreaming
JO  - Arch. Gen. Psychiatry
JF  - Arch. Gen. Psychiatry
Y1  - 1978/10/01/
VL  - 35
IS  - Oct
SP  - 1239
EP  - 1243
AD  - National Institute of Mental Health, Unit on Sleep Studies, BPB, Bldg. 10, Rm. 3N224, Bethesda, MD 20014; and St. Elizabeth's Hospital, Washington, D.C.
N1  - Accession Number: 16-4113; Language: English; Trade Name: Antilirium; Generic Name: Physostigmine; Chemical Name: Physostigmine--57-47-6; Therapeutic Class: (12:04); AHFS Class: Parasympathomimetic agents physostigmine; References: 23; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata
N2  - In a study with 17 paid normal volunteers between 20 and 38-yr-old, an IV infusion of either placebo or physostigmine (Antilirium; I), 0.5 mg/night was administered to determine the effects of I on sleep and dreaming. It was shown that dreaming occurred during I induced rapid eye movement sleep, but it did not alter mentation during non-rapid eye movement sleep. The dreams were similar to spontaneous rapid eye movement sleep dreams in content, vividness, unusualness and emotionality. As an anticholinesterase, the drug increases the action of brain acetylcholine and induces rapid eye movement sleep in normal humans.
KW  - Physostigmine--effects-;
KW  - Parasympathomimetic agents--physostigmine--effects, sleep, dreaming, IV, patients;
KW  - Mechanism of action--physostigmine--effects, sleep, patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Klempner, M. S.
AU  - Gallin, J. I.
T1  - Inhibition of neutrophil Fc receptor function by corticosteroids.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/10//
VL  - 34
IS  - 1
M3  - Article
SP  - 137
EP  - 142
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The ability of hydrocortisone sodium succinate to inhibit the adherence of IgG-sensitized erythrocytes (EA) to human peripheral blood neutrophil monolayers is described. The steroid inhibitory effect was dose-dependent with a 32.4±2.4% decrease in EA binding at 2 × 10-4 M. There was no difference between the addition of hydrocortisone prior to or at the same time as EA and steroid interference with EA binding was completely reversible. In addition, hydrocortisone was unable to displace bound EA. These findings suggest that hydrocortisone interferes with the availability of the neutrophil Fc receptor for binding and provides further insight into the host factors which are compromised during corticosteroid administration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYDROCORTISONE
KW  - CELL receptors
KW  - ADRENOCORTICAL hormones
KW  - IMMUNOGLOBULIN G
KW  - IMMUNOGLOBULINS
KW  - MONOMOLECULAR films
N1  - Accession Number: 16253353; Klempner, M. S. 1 Gallin, J. I. 1; Affiliation:  1: The Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Oct1978, Vol. 34 Issue 1, p137; Subject Term: HYDROCORTISONE; Subject Term: CELL receptors; Subject Term: ADRENOCORTICAL hormones; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOGLOBULINS; Subject Term: MONOMOLECULAR films; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoover, Carol F.
T1  - DIFFERENTIATING SCHIZOPHRENICS THROUGH PARENTAL CONFLICT.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1978/10//
VL  - 34
IS  - 4
M3  - Article
SP  - 844
EP  - 849
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article examines the difference between young schizophrenics' conflict with parents and the marital conflict experienced by other parent couples. The study was performed by comparing 154 parents of schizophrenic, maladjusted, and community young people by using the Conflict in Marriage Scale (CIMS), an agree-disagree card sort. The test was administered twice, at intervals of a week, in order to establish reliability. Views of children were not measured in the CIMS. When the entire sample was entered together into the discriminant analysis, six identifying formulae were elicited, one for each of the diagnostic-sex groups. No indication were obtained from results that parental dissension has a role per se in producing schizophrenia, although disturbed marriages seemed to be associated with disturbed adolescents.
KW  - SCHIZOPHRENICS
KW  - MENTALLY ill
KW  - SCHIZOTYPAL personality disorder
KW  - PROBLEM youth
KW  - MARITAL conflict
KW  - DISCRIMINANT analysis
KW  - MULTIVARIATE analysis
KW  - PSYCHOMETRICS
N1  - Accession Number: 15866784; Hoover, Carol F. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Oct1978, Vol. 34 Issue 4, p844; Subject Term: SCHIZOPHRENICS; Subject Term: MENTALLY ill; Subject Term: SCHIZOTYPAL personality disorder; Subject Term: PROBLEM youth; Subject Term: MARITAL conflict; Subject Term: DISCRIMINANT analysis; Subject Term: MULTIVARIATE analysis; Subject Term: PSYCHOMETRICS; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Seidman, J. G.
AU  - Leder, Aya
AU  - Nau, Marion
AU  - Norman, Barbara
AU  - Leder, Philip
T1  - Antibody Diversity.
JO  - Science
JF  - Science
Y1  - 1978/10/06/
VL  - 202
IS  - 4363
M3  - Article
SP  - 11
EP  - 17
SN  - 00368075
AB  - Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin- producing and uncommitted (embryonic) cells, thereby establishing -the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87546694; Seidman, J. G. 1; Leder, Aya 1; Nau, Marion 1; Norman, Barbara 1; Leder, Philip 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 10/6/1978, Vol. 202 Issue 4363, p11; Number of Pages: 7p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - SCHULTZ, RICHARD M.
AU  - PAVLIDIS, NICHOLAS A.
AU  - STYLOS, WILLIAM A.
AU  - CHIRISOS, MICHAEL A.
T1  - Regulation of Macrophage Tumoricidal Function: A Role for Prostaglandins of the E Series.
JO  - Science
JF  - Science
Y1  - 1978/10/20/
VL  - 202
IS  - 4365
M3  - Article
SP  - 320
EP  - 321
SN  - 00368075
AB  - Exogenously added prostaglandins E1 and E2, but not F2α, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3 ',5 '-monophosphate (cyclic AMP) in modulating macrophagefunctional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85233214; SCHULTZ, RICHARD M. 1; PAVLIDIS, NICHOLAS A. 1; STYLOS, WILLIAM A. 1; CHIRISOS, MICHAEL A. 1; Affiliations: 1: Laboratory of RNA Tumor Viruses, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/20/1978, Vol. 202 Issue 4365, p320; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WYLER, DAVID J.
AU  - WAHL, SHARON M.
AU  - WAHL, LARRY M.
T1  - Hepatic Fibrosis in Schistosomiasis: Egg Granulomas Secrete Fibroblast Stimulating Factor in vitro.
JO  - Science
JF  - Science
Y1  - 1978/10/27/
VL  - 202
IS  - 4366
M3  - Article
SP  - 438
EP  - 440
SN  - 00368075
AB  - Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218617; WYLER, DAVID J. 1; WAHL, SHARON M. 2; WAHL, LARRY M. 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Microbiology and Immunology, National Institute of Dental Research; Issue Info: 10/27/1978, Vol. 202 Issue 4366, p438; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - ABST
AU  - Baker, J. J.
AU  - Wright, W. E.
AU  - Chan, S. P.
AU  - Oppenheim, J. J.
T1  - Longitudinal effects of clinical therapy and the edentulous state on the transformation of lymphocytes from patients with severe periodontitis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/11//
VL  - 34
IS  - 2
M3  - Abstract
SP  - 199
EP  - 205
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Twenty dentulous subjects undergoing clinical therapy for severe periodontitis were used to determine the longitudinal effects of bacterial plaque reduction on in vitro lymphocyte transformation. The therapy consisted of either complete extractions or partial extractions and periodontal surgery combined with rigorous oral hygiene. Prior to therapy lymphocytes from these subjects responded significantly to Streptolysin O (SLO) but were not transformed significantly by solubilized dental plaque. However, after therapy lymphocytes from these same subjects responded significantly to both solubilized dental plaque and SLO. This indicates that the severe periodontitis patients were specifically unresponsive to solubilized dental plaque prior to therapy. The mechanism of the unresponsiveness is not clear, but probably does not involve serum factors because supplementation of the lymphocyte cultures with pooled homologous plasma from individuals with gingivitis or moderate periodontitis (instead of the patient's autologous plasma) did not significantly change the mean lymphocyte responses to solubilized dental plaque. In addition, lymphocytes from eleven long-term (5-18 yr) edentulous subjects, who were free of oral inflammation, were significantly transformed by solubilized dental plaque. The latter lymphocyte responses and those of the treated periodontitis patients could be due either to the presence of low levels of oral bacteria in the edentulous mouth or to the lymphocyte transformation assay being a measure of previous antigen sensitization rather than current disease status. In either case, lymphocyte transformation to solubilized dental plaque is not a useful diagnostic tool in periodontitis, but should continue to be a valuable research tool for investigating pathological mechanisms in periodontitis. [ABSTRACT FROM AUTHOR]
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KW  - PERIODONTITIS
KW  - INFLAMMATION
KW  - LYMPHOCYTES
KW  - DENTAL plaque
KW  - THERAPEUTICS
KW  - EDENTULOUS mouth
N1  - Accession Number: 16434982; Baker, J. J. 1 Wright, W. E. 2 Chan, S. P. 1 Oppenheim, J. J. 3; Affiliation:  1: Department of Immunology Litton Bionetics, Kensington, Maryland, U.S.A.  2: Clinical Dental Services Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov1978, Vol. 34 Issue 2, p199; Subject Term: PERIODONTITIS; Subject Term: INFLAMMATION; Subject Term: LYMPHOCYTES; Subject Term: DENTAL plaque; Subject Term: THERAPEUTICS; Subject Term: EDENTULOUS mouth; Number of Pages: 7p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fauci, A. S.
AU  - Pratt, Karen R.
AU  - Whalen, Gail
T1  - Activation of human B lymphocytes. VIII. DIFFERENTIAL RADIOSENSITIVITY OF SUBPOPULATIONS OF LYMPHOID CELLS INVOLVED IN THE POLYCLONALLY-INDUCED PFC RESPONSES OF PERIPHERAL BLOOD B LYMPHOCYTES.
JO  - Immunology
JF  - Immunology
Y1  - 1978/11//
VL  - 35
IS  - 5
M3  - Article
SP  - 715
EP  - 720
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The differential effect of various doses of irradiation on subpopulations of human peripheral blood lymphoid cells involved in the pokeweed mitogen (PWM) induced PFC response against sheep red blood cells (SRBC) was studied. The plaque forming B cells were quite sensitive to low doses of irradiation with complete suppression of responses at 300 to 500 rad. On the contrary, helper T-cell function was resistant to 2000 rad. Co-culture of irradiated T cells with autologous or allogeneic B cells resulted in marked enhancement of PFC responses consistent with the suppression of naturally occurring suppressor cells with a resulting pure helper effect. Irradiated T-cell-depleted suspensions failed to produce this effect as did heat killed T cells, whereas mitomycin C treated T cells gave effects similar to irradiated T cells. These findings are consistent with a lack of requirement of cell division for a T-cell helper effect and a requirement of mitosis or another irradiation sensitive, mitomycin C sensitive process for a T-suppressor cell effect. These studies have potential relevance in the evaluation of subpopulations of human lymphoid cells involved in antibody production in normal individuals and in disease states. [ABSTRACT FROM AUTHOR]
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KW  - B cells
KW  - IRRADIATION
KW  - LYMPHOCYTES
KW  - CELL proliferation
KW  - ANTIGEN presenting cells
KW  - BLOOD cells
KW  - IMMUNOSUPPRESSIVE agents
KW  - IMMUNOLOGY
N1  - Accession Number: 13954308; Fauci, A. S. 1 Pratt, Karen R. 1 Whalen, Gail 1; Affiliation:  1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Nov78, Vol. 35 Issue 5, p715; Subject Term: B cells; Subject Term: IRRADIATION; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Subject Term: ANTIGEN presenting cells; Subject Term: BLOOD cells; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hooks, John J.
T1  - Possibility of a viral etiology in recurrent aphthous ulcers and Behcet's syndrome.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1978/11//
VL  - 7
IS  - 6
M3  - Article
SP  - 353
EP  - 364
SN  - 03009777
AB  - The clinical signs, laboratory data, and histological features of recurrent aphthous ulcers (RAU) and Behçet's syndrome suggest a viral etiology. In fact, there are reports of adenovirus isolations in herpetiform oral ulcers and on the isolation of a filterable agent in sporadic cases of Behçet's syndrome. However, isolation studies on the major and minor aphthous ulcers and more recent studies on Behçet's syndrome have been negative. A review of the literature on the role of viruses and autoimmunity in RAU and Behçet's syndrome is presented. Biopsy specimens of ulcerative lesions were grown <em>in vitro</em> for up to 300 days. Those cultures, along with leukocytes and body fluids, were examined by a variety of techniques for the presence of virus or viral antigens. Although a persistent or latent virus was not detected, these negative studies cannot elude a viral etiology. In fact, the hypothesis of an infectious and viral etiology is still reasonable. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISEASES -- Causes & theories of causation
KW  - FOOT & mouth disease
KW  - BEHCET'S disease
KW  - ORAL diseases
KW  - BIOPSY
KW  - SYMPTOMS
N1  - Accession Number: 14875649; Hooks, John J. 1; Affiliation:  1: Laboratory of Oral Medicine, National Institute of Dental Research, National institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: 1978, Vol. 7 Issue 6, p353; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: FOOT & mouth disease; Subject Term: BEHCET'S disease; Subject Term: ORAL diseases; Subject Term: BIOPSY; Subject Term: SYMPTOMS; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1600-0714.ep14875649
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Graykowski, Edward A.
AU  - Kingman, Albert
T1  - Double-blind trial of tetracycline in recurrent aphthous ulceration.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1978/11//
VL  - 7
IS  - 6
M3  - Article
SP  - 376
EP  - 382
SN  - 03009777
AB  - A double-blind trial of a tetracycline suspension was carried out in 25 patients with recurrent aphthous oral ulcerations. A combined topical-systemic treatment procedure was used. Both the placebo and tetracycline groups experienced reductions in ulcer incidence during the treatment period, whereas only the tetracycline group showed significant reductions in ulcer duration, size, and pain. Tetracycline treatment apparently alters the severity of the ulcer, but does not appear to affect those factors responsible for recurrences. The side effects recorded in patients taking tetracycline were comparable to those in patients on placebo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TETRACYCLINE
KW  - PAIN
KW  - FOOT & mouth disease
KW  - ULCERS
KW  - PLACEBOS (Medicine)
KW  - THERAPEUTICS
N1  - Accession Number: 14875661; Graykowski, Edward A. 1 Kingman, Albert 1; Affiliation:  1: Laboratory of Oral Medicine and National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: 1978, Vol. 7 Issue 6, p376; Subject Term: TETRACYCLINE; Subject Term: PAIN; Subject Term: FOOT & mouth disease; Subject Term: ULCERS; Subject Term: PLACEBOS (Medicine); Subject Term: THERAPEUTICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1600-0714.ep14875661
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Benezra, David
AU  - Nussenblatt, Robert
T1  - Ocular manifestations of Behcet's disease.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1978/11//
VL  - 7
IS  - 6
M3  - Article
SP  - 431
EP  - 435
SN  - 03009777
AB  - The manifestations, possible etiological factors and therapeutical modalities of ocular Behçet are outlined. The major ocular findings involve both the anterior and posterior uvea. The vasculitis retinae, the periphlebitis and the pipe stem sheathing along with the recurrent vitreous hemorrhages lead to the visual impairment. Exacerbation and remission of the ocular inflammatory processes are characteristic. However, the impairment of visual function occurring after each attack is generally irreversible. The effectiveness of the present modalities of treatment is uncertain. Chlorambucil® in doses of 6-8 mg daily appears to have an outstanding beneficial effect. However, carefully monitored control studies are lacking and should be conducted before any unequivocal conclusions can he reached. It appears to us that the etiology-pathology of Behçet's disease might be a sequence of events triggered by an interaction between a virus and specific receptors on the host cell membrane (HLA determined?). This initial interaction is followed by a malregulation of the host immune mechanism Leading to autoinmmune phenomena which are characteristics of the disease. [ABSTRACT FROM AUTHOR]
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KW  - OCULAR manifestations of general diseases
KW  - BEHCET'S disease
KW  - SYMPTOMS
KW  - POSTERIOR uveitis
KW  - DISEASES -- Causes & theories of causation
KW  - CELL membranes
N1  - Accession Number: 14875674; Benezra, David 1 Nussenblatt, Robert 1; Affiliation:  1: Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: 1978, Vol. 7 Issue 6, p431; Subject Term: OCULAR manifestations of general diseases; Subject Term: BEHCET'S disease; Subject Term: SYMPTOMS; Subject Term: POSTERIOR uveitis; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: CELL membranes; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1600-0714.ep14875674
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sostek, Andrew J.
T1  - Effects of Electrodermal Lability and Payoff Instructions on Vigilance Performance.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1978/11//
VL  - 15
IS  - 6
M3  - Article
SP  - 561
EP  - 568
SN  - 00485772
AB  - The psychophysiologically based personality dimension of electrodermal lability has been related to vigilance performance. The present study investigated this effect basing lability on spontaneous electrodermal fluctuations and habituation of the electrodermal orienting response, and attempted to modify performance using monetary payoffs. In an auditory vigilance task, detections and sensitivity (d') declined across blocks, and payoffs influenced detections, commission errors, d', and response bias in the expected directions. Although there were no main effects for spontaneous lability, habituation labiles had higher log false alarm rates, lower response bias and tended to detect more signals. Using either lability criterion, labiles did not demonstrate a vigilance decrement and were more responsive than stabiles to payoff instructions. Lability based on habituation rate was therefore more clearly related to vigilance performance than lability based on spontaneous fluctuations. [ABSTRACT FROM AUTHOR]
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KW  - HABITUATION (Neuropsychology)
KW  - GALVANIC skin response
KW  - INTROVERSION
KW  - EXTRAVERSION
KW  - SENSATION seeking
KW  - Electrodermal lability
KW  - Habituation sensitivity
KW  - Introversion-extraversion
KW  - Response bias
KW  - Sensation seeking.
KW  - Vigilance
N1  - Accession Number: 11189463; Sostek, Andrew J. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Nov1978, Vol. 15 Issue 6, p561; Subject Term: HABITUATION (Neuropsychology); Subject Term: GALVANIC skin response; Subject Term: INTROVERSION; Subject Term: EXTRAVERSION; Subject Term: SENSATION seeking; Author-Supplied Keyword: Electrodermal lability; Author-Supplied Keyword: Habituation sensitivity; Author-Supplied Keyword: Introversion-extraversion; Author-Supplied Keyword: Response bias; Author-Supplied Keyword: Sensation seeking.; Author-Supplied Keyword: Vigilance; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-8986.ep11189463
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Guenthner, Thomas M.
AU  - Nebert, Daniel W.
T1  - Evidence in Rat and Mouse Liver for Temporal Control of Two Forms of Cytochrome <em>P</em>-450 Inducible by 2,3,7,8-Tetrachlorodibenzo-<em>p</em>-dioxin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/11/15/
VL  - 91
IS  - 2
M3  - Article
SP  - 449
EP  - 456
PB  - Wiley-Blackwell
SN  - 00142956
AB  - In the liver of perinatal rats or mice, the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon hydroxylase to total cytochrome P-450 content decreases, whereas the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced acetanilide 4-hydroxylase to total cytochrome P-450 content increases, between 18 or 19 days and 22 days following conception. The ontogenesis of inducible aryl hydrocarbon hydroxylase corresponds well with increases in a 56000-Mr electrophoretic band; we suggest this band represents the cytochrome P1-450 subunit. The later temporal expression of inducible acetanilide 4-hydroxylase closely parallels 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced increases in size of a 54000-Mr electrophoretic band and a 2–3-nm hypsochromic shift in the Soret peak of the total microsomal reduced cytochrome P450 · CO complex. We suggest this band represents the cytochrome P-448 subunit. Previous work from this laboratory has shown that this developmental difference is separated by several weeks in rabbit liver, as compared with several day's separation shown in this report with rat or mouse liver. The data here therefore provide evidence in the rodent for temporal control of the expression of different structural gene products regulated by the Ah locus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TETRACHLORODIBENZODIOXIN
KW  - HYDROCARBONS
KW  - CYTOCHROME P-450
KW  - MICROSOMES
KW  - PROTEIN synthesis
KW  - GENETIC regulation
N1  - Accession Number: 13696496; Guenthner, Thomas M. 1 Nebert, Daniel W. 1; Affiliation:  1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: 11/15/78, Vol. 91 Issue 2, p449; Subject Term: TETRACHLORODIBENZODIOXIN; Subject Term: HYDROCARBONS; Subject Term: CYTOCHROME P-450; Subject Term: MICROSOMES; Subject Term: PROTEIN synthesis; Subject Term: GENETIC regulation; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hasilik, Andrej
AU  - Tanner, Widmar
T1  - Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/11/15/
VL  - 91
IS  - 2
M3  - Article
SP  - 567
EP  - 575
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Carboxypeptidase Y purified from bakers yeast, Mr 61000, contains 2.7% glucosamine and 14.1% mannose, which correspond to 8 and 53 residues/molecule respectively. By digesting the enzyme with a mixture of proteinases glycopeptides are released containing aspartic acid/asparagine, glucosamine and mannose in a ratio of 1.5:2:13. Oligosaccharides obtained after hydrazinolysis are composed of glucosamine and mannose. Four asparagine-linked oligosaccharides of the general formula (GlcNAc)2(Man)13 are proposed to be present in carboxypeptidase Y. Similar antigenicity and immunoreactivity properties of the enzyme and of cell wall mannan indicate a close structural relationship of their sugar moieties. The enzyme synthesized in the presence of tunicamycin has a molecular weight of about 51000,just as expected if devoid of sugar. Tunicamycin also reduces specifically the amount of the carbohydrate-free protein present in the cells. Since this product is metabolically stable, the reduced amount must be due to an inhibited rate of biosynthesis. This indicates a regulatory link between the glycosylation of the protein moiety and its biosynthesis. Like the normal carboxypeptidase Y also the carbohydrate-free form is synthesized via a larger precursor. The processing of the precursor in vivo and in vitro is not affected by the absence of its carbohydrate portion. The size of the enzyme formed in the presence of 2-deoxyglucose is reduced too, although to a lesser extent. A glucosamine auxotroph, if starved for glucosamine, synthesizes in part a carboxypeptidase Y species analogous to that found in the cells poisoned by tunicamycin. Isolation of carboxypeptidase Y from the starved mutant cells is described. Experiments on glycosylation of such carboxypeptidase h7 vitro (also after its denaturation) have been negative, however. [ABSTRACT FROM AUTHOR]
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KW  - CARBOXYPEPTIDASES
KW  - GLUCOSAMINE
KW  - MANNOSE
KW  - BIOSYNTHESIS
KW  - ASPARAGINE
KW  - OLIGOSACCHARIDES
KW  - TUNICAMYCIN
N1  - Accession Number: 13697461; Hasilik, Andrej 1,2 Tanner, Widmar 1; Affiliation:  1: Fachbereich Biologie und Vorkklinische Medizin der Universität Regensburg  2: National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, U.S.A.; Source Info: 11/15/78, Vol. 91 Issue 2, p567; Subject Term: CARBOXYPEPTIDASES; Subject Term: GLUCOSAMINE; Subject Term: MANNOSE; Subject Term: BIOSYNTHESIS; Subject Term: ASPARAGINE; Subject Term: OLIGOSACCHARIDES; Subject Term: TUNICAMYCIN; Number of Pages: 9p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - KRAMER, MORTON
AU  - GRUENBERG, ERNEST M.
AU  - GORI, GIO B.
AU  - RICHTER, BRIAN J.
T1  - Prevention of Long-Term and Disabling Diseases.
JO  - Science
JF  - Science
Y1  - 1978/11/17/
VL  - 202
IS  - 4369
M3  - Article
SP  - 697
EP  - 698
SN  - 00368075
N1  - Accession Number: 85268563; KRAMER, MORTON 1; GRUENBERG, ERNEST M. 1; GORI, GIO B. 2; RICHTER, BRIAN J. 3; Affiliations: 1: School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205; 2: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; 3: Enviro Control, Inc., Rockville, Maryland 20852; Issue Info: 11/17/1978, Vol. 202 Issue 4369, p697; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - GOLDMAN, PATRICIA S.
T1  - Neuronal Plasticity in Primate Telencephalon: Anomalous Projections Induced by Prenatal Removal of Frontal Cortex.
JO  - Science
JF  - Science
Y1  - 1978/11/17/
VL  - 202
IS  - 4369
M3  - Article
SP  - 768
EP  - 770
SN  - 00368075
AB  - When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268598; GOLDMAN, PATRICIA S. 1; Affiliations: 1: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 11/17/1978, Vol. 202 Issue 4369, p768; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - PAUL, STEVEN M.
AU  - SKOLNICK, PHIL
T1  - Rapid Changes in Brain Benzodiazepine Receptors After Experimental Seizures.
JO  - Science
JF  - Science
Y1  - 1978/11/24/
VL  - 202
IS  - 4370
M3  - Article
SP  - 892
EP  - 894
SN  - 00368075
AB  - Seizures induced in the rat by electroshock or by injections of pentylenetetrazol increase the specific binding of diazepam to putative receptor sites in cerebral cortical membranes. The enhancement of diazepam binding results from a rapid increase in the number of available binding sites rather than a change in receptor affinity. The postictal increase in cortical benzodiazepine receptors suggests that the cerebral cortex might be more sensitive to the anticonvulsant effects of the benzodiazepines after seizures. This observation may be related to the mechanism of action of these drugs in the treatment of recurrent seizures such as status epilepticus. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268635; PAUL, STEVEN M. 1; SKOLNICK, PHIL 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Biopsychosocial Research, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20857; Issue Info: 11/24/1978, Vol. 202 Issue 4370, p892; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - IUVONE, P. MICHAEL
AU  - GALLI, C. L.
AU  - GARRISON-GUND, C. K.
AU  - NEFF, N. H.
T1  - Light Stimulates Tyrosine Hydroxylase Activity and Dopamine Synthesis in Retinal Amacrine Neurons.
JO  - Science
JF  - Science
Y1  - 1978/11/24/
VL  - 202
IS  - 4370
M3  - Article
SP  - 901
EP  - 902
SN  - 00368075
AB  - Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine formation in vivo and a concomitant increase in the activity of tyrosine hydroxylase, measured in vitro with a subsaturating concentration of pteridine cofactor. Activation of tyrosine hydroxylase also occurs when isolated eyes from rats killed in the dark are exposed to a strobe light. Studies of amacrine neurons should provide basic data about the biochemical processing of visual information, as well as the physiological presynaptic regulatory mechanisms of dopamine-containing neurons. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268639; IUVONE, P. MICHAEL 1; GALLI, C. L. 1; GARRISON-GUND, C. K. 1; NEFF, N. H. 1; Affiliations: 1: Laboratory of Preclinical Phamacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 11/24/1978, Vol. 202 Issue 4370, p901; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Kirkpatrick, C. H.
AU  - Greenberg, Lynn E.
AU  - Chapman, S. W.
AU  - Goldstein, G.
AU  - Lewis, Verna M.
AU  - Twomey, J. J.
T1  - Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1978/12//
VL  - 34
IS  - 3
M3  - Article
SP  - 311
EP  - 317
PB  - Wiley-Blackwell
SN  - 00099104
AB  - To further characterize the immunological abnormalities in patients with chronic mucocutaneous candidiasis, the thymic hormone activity in their plasma was measured. Of the sixteen patients in the study, seven had chronic diffuse candidiasis, five had candidiasis with endocrinopathies and four had candidiasis with thymoma. Only one patient, an anergic child with chronic diffuse candidiasis had severe deficiency of plasma thymic hormone activity. Two patients, a woman with candidiasis and multiple endocrinopathies and an elderly man with metastatic epithelial thymoma had supranomal values. These studies indicate that the immunological deficit in most patients with these forms of chronic mucucutaneous candidiasis is not due to deficiency of a thymic inductive activity and suggest that an intrinsic defect exists in the maturation of antigen-responsive lymphoid cells. [ABSTRACT FROM AUTHOR]
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KW  - CANDIDIASIS
KW  - THYMIC hormones
KW  - BLOOD plasma
KW  - LYMPHOID tissue
KW  - MYCOSES
KW  - THYMUS extract
N1  - Accession Number: 16616163; Kirkpatrick, C. H. 1,2,3 Greenberg, Lynn E. 1,2,3 Chapman, S. W. 1,2,3 Goldstein, G. 1,2,3 Lewis, Verna M. 1,2,3 Twomey, J. J. 1,2,3; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bathesda, Maryland, USA.  2: Ortho Pharmaceutical Corporation, Raritan, New Jersey, USA.  3: Immunohematology Research Laboratory, Veterans Administration Hospital, Houston, Texas, USA.; Source Info: Dec1978, Vol. 34 Issue 3, p311; Subject Term: CANDIDIASIS; Subject Term: THYMIC hormones; Subject Term: BLOOD plasma; Subject Term: LYMPHOID tissue; Subject Term: MYCOSES; Subject Term: THYMUS extract; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Wodnar-Filipowicz, Aleksandra
AU  - Szcz&ecedil;na, Elzbieta
AU  - Zan-Kowalczewska, Malgorzata
AU  - Muthukrishnan, Subbaratnam
AU  - Szybiak, Urszula
AU  - Legocki, Andrzej B.
AU  - Filipowicz, Witold
T1  - 5'-Terminal 7-Methylguanosine and mRNA Function.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1978/12//12/1/78
VL  - 92
IS  - 1
M3  - Article
SP  - 69
EP  - 80
PB  - Wiley-Blackwell
SN  - 00142956
AB  - 1. Decapped tobacco mosaic virus (TMV) RNA and rabbit globin mRNA were prepared by enzymic treatment of RNAs with nucleotide pyrophosphatase purified from potato. The extent of removal of 5'-terminal 7-methylguanosine 5'-monophosphate (m GMP) from TMV RNA was at least 97% as estimated by labeling of the 5' termini in vitro with S-adenosyl[methyl-³H]methionine catalysed by vaccinia virus methyltransferases. 2. The effect of enzymic decapping was compared with the effect of cap analogs on mRNAs translation in a nuclease-treated rabbit reticulocyte lysate and in a wheat germ extract. When translation was studied at low K+ concentration, little or no dependence on 5'-terminal 7-methylguanosine was found with either cell-free system. The importance of the 5'-terminal cap for the efficient translation of TMV RNA and globin mRNA increased as the concentration of K+ in a protein-synthesis system was raised. In a reticulocyte lysate analogs and enzymic decapping had a similar effect on translation. In a wheat germ extract, mRNA decapping resulted in a more pronounced decrease of mRNA activity, presumably due to the increased susceptibility of decapped mRNAs to the nucleases present in this protein synthesis system. 3. The requirement for a 5'-terminal cap was similar for the synthesis of 130 000-Mr and 165 000-Mr polypeptides coded by TMV RNA. This indicates that both proteins may be initiated at the common site close to the 5' terminus. [ABSTRACT FROM AUTHOR]
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KW  - MESSENGER RNA
KW  - PLANT viruses
KW  - GLOBIN genes
KW  - NUCLEOTIDES
KW  - PYROPHOSPHATES
KW  - ADENOSYLMETHIONINE
N1  - Accession Number: 13698710; Wodnar-Filipowicz, Aleksandra 1,2,3 Szcz&ecedil;na, Elzbieta 1,2,3 Zan-Kowalczewska, Malgorzata 1,2,3 Muthukrishnan, Subbaratnam 1,2,3 Szybiak, Urszula 1,2,3 Legocki, Andrzej B. 1,2,3 Filipowicz, Witold 1,2,3; Affiliation:  1: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw  2: Institute of Biochemistry, University of Agriculture, Poznań  3: National Institutes of Health, Bethesda, Maryland; Source Info: 12/1/78, Vol. 92 Issue 1, p69; Subject Term: MESSENGER RNA; Subject Term: PLANT viruses; Subject Term: GLOBIN genes; Subject Term: NUCLEOTIDES; Subject Term: PYROPHOSPHATES; Subject Term: ADENOSYLMETHIONINE; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Snippe, H.
AU  - Merchant, B.
AU  - Johannessen, L.
AU  - Inman, J. K.
T1  - Effects of cyclophosphamide on the in vivo response of outbred athymic (nude) mice to a thymus-independent antigen (DNP-AGG-Ficoll).
JO  - Immunology
JF  - Immunology
Y1  - 1978/12//
VL  - 35
IS  - 6
M3  - Article
SP  - 1009
EP  - 1015
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Both nude mice (nu/nu) and their heterozygous littermates (nu/+) were injected with a single IP dose of 300 mg cyclophosphamide (CY)/kg. CY is a known immunosuppressive agent, which affects primarily B lymphocytes. Immunization with the thymus independent antigen DNP-AGG59- Ficoll after CY treatment disclosed that restoration of the primary direct PFC response occurred more rapidly in nude mice than in nu/+ mice. However in these same experiments, the primary indirect PFC response, recovered earlier in nu/+ mice than in nude mice. After CY treatment, secondary indirect PFC responses were delayed in both nude and nu/+ mice, but the greatest effect was seen in nude mice. The data suggest that the presence of T cells has little if any influence on the recovery capacity of those B cells which are destined to become direct PFC. However the recovery of B cells which are destined to produce indirect PFC responses is facilitated by the presence of T cells. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNIZATION
KW  - IMMUNOTHERAPY
KW  - THYMUS
KW  - ANTIGENS
KW  - FICOLL
KW  - LYMPHOCYTES
KW  - B cells
KW  - T cells
KW  - ANTIGEN presenting cells
N1  - Accession Number: 15789199; Snippe, H. 1,2 Merchant, B. 1,2 Johannessen, L. 1,2 Inman, J. K. 1,2; Affiliation:  1: Division of Blood and Blood Products, Bureau of Biologies, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20014  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Source Info: Dec78, Vol. 35 Issue 6, p1009; Subject Term: IMMUNIZATION; Subject Term: IMMUNOTHERAPY; Subject Term: THYMUS; Subject Term: ANTIGENS; Subject Term: FICOLL; Subject Term: LYMPHOCYTES; Subject Term: B cells; Subject Term: T cells; Subject Term: ANTIGEN presenting cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gail, Mitchell H.
AU  - Gastwirth, Joseph L.
T1  - A Scale-Free Goodness-of-Fit Test for the Exponential Distribution Based on the Lorenz Curve.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1978/12//
VL  - 73
IS  - 364
M3  - Article
SP  - 787
SN  - 01621459
AB  - The sample Lorenz curve provides a powerful, easily computed goodness-of-fit test for exponentiality which does not depend on the unknown scale parameter. Exact critical values and asymptotic results are given, which can also be used to test the related hypothesis of randomness on an interval. General limit theorems show that the sample Lorenz curve converges almost surely to the population Lorenz curve and that the standardized Lorenz statistic converges to normality provided the underlying random variable has finite variance. Asymptotic relative efficiencies and Monte Carlo power estimates are also given. [ABSTRACT FROM AUTHOR]
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KW  - LORENZ curve
KW  - DISTRIBUTION (Probability theory)
KW  - MONTE Carlo method
KW  - MATHEMATICAL statistics
KW  - GOODNESS-of-fit tests
KW  - EXPONENTIAL families (Statistics)
KW  - LIMIT theorems (Probability theory)
KW  - HYPOTHESIS
KW  - Concentration curve
KW  - Exponential distribution
KW  - Goodness of fit
KW  - Lorenz curve
KW  - Randomness on an interval.
N1  - Accession Number: 4605617; Gail, Mitchell H. 1; Gastwirth, Joseph L. 2; Affiliations: 1: Medical statistician, National Cancer Institute, Landow C509, Bethesda, MD 20014.; 2: Professor of Statistics and Economics, George Washington University, Washington, DC 20052.; Issue Info: Dec78, Vol. 73 Issue 364, p787; Thesaurus Term: LORENZ curve; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MONTE Carlo method; Thesaurus Term: MATHEMATICAL statistics; Subject Term: GOODNESS-of-fit tests; Subject Term: EXPONENTIAL families (Statistics); Subject Term: LIMIT theorems (Probability theory); Subject Term: HYPOTHESIS; Author-Supplied Keyword: Concentration curve; Author-Supplied Keyword: Exponential distribution; Author-Supplied Keyword: Goodness of fit; Author-Supplied Keyword: Lorenz curve; Author-Supplied Keyword: Randomness on an interval.; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rogan, Walter J.
T1  - Clinical Biostatistics (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1978/12//
VL  - 73
IS  - 364
M3  - Book Review
SP  - 897
SN  - 01621459
AB  - Reviews the book "Clinical Biostatistics," by Alvan R. Feinstein.
KW  - BIOMETRY
KW  - NONFICTION
KW  - FEINSTEIN, Alvan
KW  - FEINSTEIN, Alvan R.
KW  - CLINICAL Biostatistics (Book)
N1  - Accession Number: 4606841; Rogan, Walter J. 1; Affiliations: 1: National Institute of Environmental Health Sciences.; Issue Info: Dec78, Vol. 73 Issue 364, p897; Subject Term: BIOMETRY; Subject Term: NONFICTION; Reviews & Products: CLINICAL Biostatistics (Book); People: FEINSTEIN, Alvan; People: FEINSTEIN, Alvan R.; Number of Pages: 1/4p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - MARGULES, DAVID L.
AU  - MOISSET, BEATRIZ
AU  - LEWIS, MICHAEL J.
AU  - SHIBUYA, HARUO
AU  - PERT, CANDACE B.
T1  - ß-Endorphin Is Associated with Overeating in Genetically Obese Mice (ob/ob) and Rats (fa/fa).
JO  - Science
JF  - Science
Y1  - 1978/12//12/ 1/1978
VL  - 202
IS  - 4371
M3  - Article
SP  - 988
EP  - 991
SN  - 00368075
AB  - Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (falfa). Elevated concentrations of the naturally occurring opiate ß-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of ß-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary ß- endorphin may play a role in the development of the overeating and obesity syndrome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218746; MARGULES, DAVID L. 1; MOISSET, BEATRIZ 1; LEWIS, MICHAEL J. 2; SHIBUYA, HARUO 3; PERT, CANDACE B. 3; Affiliations: 1: Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122; 2: Department of Psychology, Tufts University, Medford, Massachusetts 02155; 3: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 12/ 1/1978, Vol. 202 Issue 4371, p988; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BIRD, STEPHANIE J.
AU  - GULLEY, ROBERT L.
AU  - WENTHOLD, ROBERT J.
AU  - FEX, JÖRGEN
T1  - Kainic Acid Injections Result in Degeneration of Cochlear Nucleus Cells Innervated by the Auditory Nerve.
JO  - Science
JF  - Science
Y1  - 1978/12/08/
VL  - 202
IS  - 4372
M3  - Article
SP  - 1087
EP  - 1089
SN  - 00368075
AB  - When kainic acid, a putative neurotoxin for neurons with glutamatergic input, is injected into the brainstem, it produces a selective pattern of degeneration in the cochlear nucleus. The rate and extent of degeneration is correlated with the distribution of the primary auditoryfibers. This evidence supports the hypothesis that glutamate is the neurotransmitter for primary auditory fibers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218778; BIRD, STEPHANIE J. 1; GULLEY, ROBERT L. 2; WENTHOLD, ROBERT J. 3; FEX, JÖRGEN 3; Affiliations: 1: Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106; 2: Department of Anatomy, School of Medicine, Case Western Reserve University; 3: Laboratory of Neuro-otolaryngology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1087; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MACLEOD, COLIN M.
AU  - DEKABAN, ANATOLE S.
AU  - HUNT, EARL
T1  - Memory Impairment in Epileptic Patients: Selective Effects of Phenobarbital Concentration.
JO  - Science
JF  - Science
Y1  - 1978/12/08/
VL  - 202
IS  - 4372
M3  - Article
SP  - 1102
EP  - 1104
SN  - 00368075
AB  - Nineteen epileptic patients were tested first under medium (week 1) and then under high (week 2) therapeutic levels of phenobarbital. Relative to response times of 20 controls with equivalent practice but without medication, response times of patients in a short-term memory scanning task were strikingly slowed during week 2. However, increased phenobarbital did not slow responses in a task requiring access to information in long-term memory. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218784; MACLEOD, COLIN M. 1; DEKABAN, ANATOLE S. 2; HUNT, EARL 3; Affiliations: 1: Department of Psychology, University of Washington, Seattle 98195; 2: Developmental and Metabolic Neurology Branch, National Institutes of Health Bethesda, Maryland 20014; 3: Department of Psychology, University of Washington; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1102; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ALLING, DAVID W.
AU  - HALPERIN, MAX
AU  - WARE, JAMES H.
AU  - TUKEY, JOHN W.
T1  - Controlled Clinical Trials.
JO  - Science
JF  - Science
Y1  - 1978/12/08/
VL  - 202
IS  - 4372
M3  - Article
SP  - 1105
EP  - 1105
SN  - 00368075
N1  - Accession Number: 85218785; ALLING, DAVID W. 1; HALPERIN, MAX 1; WARE, JAMES H. 1; TUKEY, JOHN W. 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; 2: Bell Laboratories, Murray Hill, New Jersey 07974; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1105; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BROWN, CHARLES C.
AU  - FEARS, THOMAS R.
AU  - GAIL, MITCHELL H.
AU  - SCHNEIDERMAN, MARVIN A.
AU  - TARONE, ROBERT E.
AU  - MANTEL, NATHAN
AU  - MCGAUGHEY, CHARLES
AU  - CRUMP, KENNY S.
AU  - NEYMAN, JERZY
AU  - SCHERER, E.
AU  - EMMELOT, P.
AU  - CORNFIELD, JEROME
T1  - Models for Carcinogenic Risk Assessment.
JO  - Science
JF  - Science
Y1  - 1978/12/08/
VL  - 202
IS  - 4372
M3  - Article
SP  - 1105
EP  - 1109
SN  - 00368075
N1  - Accession Number: 85218786; BROWN, CHARLES C. 1; FEARS, THOMAS R. 1; GAIL, MITCHELL H. 1; SCHNEIDERMAN, MARVIN A. 1; TARONE, ROBERT E. 1; MANTEL, NATHAN 2; MCGAUGHEY, CHARLES 3; CRUMP, KENNY S. 4; NEYMAN, JERZY 5; SCHERER, E. 6; EMMELOT, P. 6; CORNFIELD, JEROME 7; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Biostatistics Center, George Washington University, Bethesda, Maryland 20014; 3: Oral Diseases Research Laboratory, Veterans Administration Hospital, Long Beach, California 90822; 4: Department of Mathematics and Statistics, Louisiana Tech University, Ruston 71272; 5: Statistical Laboratory, University of California, Berkeley 94720; 6: Division of Chemical Carcinogenesis, Antoni van Leeuwenhoek-Huis, Netherlands Cancer Institute, Amsterdam, Netherlands; 7: Department of Statistics, Biostatistics Center, George Washington University, Bethesda, Maryland 20014; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1105; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CUMMINGS, MARTIN M.
T1  - Informtion Tiansfer: The Biomedical Model.
JO  - Science
JF  - Science
Y1  - 1978/12/22/
VL  - 202
IS  - 4374
M3  - Article
SP  - 1249
EP  - 1249
SN  - 00368075
N1  - Accession Number: 85218830; CUMMINGS, MARTIN M. 1; Affiliations: 1: National Library of Medician, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/22/1978, Vol. 202 Issue 4374, p1249; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - YATVIN, MILTON B.
AU  - WEINSTEIN, JOHN N.
AU  - DENNIS, WARREN H.
AU  - BLUMENTHAL, ROBERT
T1  - Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia.
JO  - Science
JF  - Science
Y1  - 1978/12/22/
VL  - 202
IS  - 4374
M3  - Article
SP  - 1290
EP  - 1293
SN  - 00368075
AB  - Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44°C to that at 37°C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218853; YATVIN, MILTON B. 1; WEINSTEIN, JOHN N. 2; DENNIS, WARREN H. 3; BLUMENTHAL, ROBERT 4; Affiliations: 1: Radiobiology Research Laboratories, Department of Human Oncology, University of Wisconsin, Madison 53706; 2: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 3: Departments of Physiology and Preventive Medicine, University of Wisconsin, Madison; 4: Laboratory of Theoretical Biology, National Cancer Institute; Issue Info: 12/22/1978, Vol. 202 Issue 4374, p1290; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HENKART, MARYANNA P.
AU  - REESE, T. S.
AU  - BRINLEY JR., F. J.
T1  - Endoplasmic Reticulum Sequesters Calcium in the Squid Giant Axon.
JO  - Science
JF  - Science
Y1  - 1978/12/22/
VL  - 202
IS  - 4374
M3  - Article
SP  - 1300
EP  - 1303
SN  - 00368075
AB  - Axons were loaded with calcium, rapidly frozen, andfreeze-substituted. The endoplasmic reticulum, in addition to mitochondria, contained calcium deposits, as indicated by electron probe x-ray microanalysis. Oxalate injected into living axons helped to preserve calcium-containing deposits during preparation for microscopy. It is concluded that the endoplasmic reticulum is a calcium-sequestering compartment in the squid giant axon. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218857; HENKART, MARYANNA P. 1; REESE, T. S. 2; BRINLEY JR., F. J. 3; Affiliations: 1: Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014; 2: National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 3: Department of Physiology, University of Maryland School of Medicine, Baltimore 21201; Issue Info: 12/22/1978, Vol. 202 Issue 4374, p1300; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-02065-000
AN  - 9999-02065-000
AU  - Achenbach, Thomas M.
AU  - Edelbrock, Craig S.
T1  - Child Behavior Profile
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1979///
AD  - Achenbach, Thomas M., National Institute of Mental Health, Laboratory of Developmental Psychology, 9000 Rockville Pike, Building 15K, 20014, Maryland, United States, 20014
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-02065-000. Other Names: Youth Self-Report Questionnaire. Acronyms: YSRQ. Partial author list: First Author & Affiliation: Achenbach, Thomas M.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20111010. Correction Date: 20151109. Language: English. Constructs: Behavioral Problems; Competency-Related Behavior; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Other Versions: 9999-20906-000, Behavioral Functioning Measure, Revision. 
N2  - Administration Method: Paper
AB  - Purpose: The Child Behavior Profile measures behavioral problems and competencies standardized for each sex at ages 4 to 5, 6 to 11, and 12 to 16.
AB  - Description: The Child Behavior Profile (Achenbach & Edelbrock, 1979) is a measure of behavioral problems and competencies standardized for each sex at ages 4 to 5, 6 to 11, and 12 to 16. Scored from the Child Behavior Checklist, the profile consists of three a priori social competence scales plus behavior problem scales that were derived through factor analysis of the checklists filled out by parents of 450 children of each sex and age group referred for mental health services. The behavior problem scales were labeled as follows: boys 12-16—Somatic Complaints, Schizoid, Uncommunicative, Immature, Obsessive-Compulsive, Hostile Withdrawal, Delinquent, Aggressive, and Hyperactive; girls 6-11—Somatic Complaints, Schizoid-Obsessive, Depressed, Social Withdrawal, Sex Problems, Cruel, Delinquent, Aggressive, and Hyperactive; girls 12-16—Somatic Complaints, Schizoid, Depressed Withdrawal, Anxious-Obsessive, Immature-Hyperactive, Cruel, Aggressive, and Delinquent. Second-order factor analyses showed that the behavior problem scales for each sample could be divided into broadband groupings called internalizing and externalizing. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Child Behavior Profiles
KW  - Externalizing Behavior Problems
KW  - Internalizing Behavior Problems
KW  - Social Competencies
KW  - Test Development
U5  - Child Behavior Profile (YSRQ) [Test Development]The Child Behavior Profile: II. Boys aged 12–16 and girls aged 6–11 and 12–16. (AN: 1979-27624-001 from PsycINFO) Achenbach, Thomas M.; Edelbrock, Craig S.; Apr, 1979. Source: Journal of Consulting and Clinical Psychology. 47(2), American Psychological Association, US; Apr, 1979; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs); Population: Human; Male; Female; Location: United States; Samples: 12-16 Yr Olds Being Evaluated in Mental Health Settings and their Parents Keywords: Child Behavior Profiles; Externalizing Behavior Problems; Internalizing Behavior Problems; Social Competencies; Test Development; Subjects: Behavior Problems; Child Behavior Checklist; Externalization; Internalization; Profiles (Measurement); Social Skills; Test Construction; Test Forms;
DO  - 10.1037/t02065-000
L3  - Full; Full text; 999902065_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Hijmans, W.
AU  - Sipe, Jean D.
T1  - Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1979/01//
VL  - 35
IS  - 1
M3  - Article
SP  - 96
EP  - 100
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Serum amyloid A (SAA) has been implicated by three independent studies to increase in concentration with ageing. The present study measured SAA concentration in 395 samples from 302 healthy individuals ranging in age from 21 to 100 years. The average SAA concentration was 2 μg/ml, with only five serum samples tailing below 5 μg/ml. SAA concentrations are expressed in terms of cross-reactivity of purified, denatured SAA with anti-AA antibodies, rather than the purified, denatured amyloid fibril protein AA from tissues, which has been used in the past. No age-related increase in SAA concentration was observed in the present study. The average SAA concentration in these normal, healthy individuals was almost a hundred-fold less than values measured in acute phase human serum in a separate study with the same reagents. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMYLOID beta-protein
KW  - GLYCOPROTEINS
KW  - AGE groups
KW  - SERUM
KW  - IMMUNOGLOBULINS
KW  - AMYLOID
N1  - Accession Number: 16616378; Hijmans, W. 1 Sipe, Jean D. 2; Affiliation:  1: The Laboratory of Experimental Pathology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA.  2: Institute for Experimental Gerontology TNO. Rijswijk, The Netherlands.; Source Info: Jan1979, Vol. 35 Issue 1, p96; Subject Term: AMYLOID beta-protein; Subject Term: GLYCOPROTEINS; Subject Term: AGE groups; Subject Term: SERUM; Subject Term: IMMUNOGLOBULINS; Subject Term: AMYLOID; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Butler, Robert N.
T1  - Sexual intimacy for older folks.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1979/01//
VL  - 34
IS  - 1
M3  - Article
SP  - 9
EP  - 9
SN  - 0016867X
N1  - Accession Number: 17333461; Butler, Robert N. 1; Source Information: Jan1979, Vol. 34 Issue 1, p9; Number of Pages: 1/3p; Document Type: Article; Full Text Word Count: 207
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - CHAP
ID  - 1990-98082-023
AN  - 1990-98082-023
AU  - Goldberg, Irving D.
AU  - Krantz, Goldie
AU  - Locke, Ben Z.
ED  - Kiesler, Charles A.
ED  - Cummings, Nicholas A.
ED  - VandenBos, Gary R.
ED  - Kiesler, Charles A., (Ed)
ED  - Cummings, Nicholas A., (Ed)
ED  - VandenBos, Gary R., (Ed)
T1  - Effect of a short-term outpatient psychiatric therapy benefit on the utilization of medical services in a prepaid group practice medical program.
T2  - Psychology and national health insurance:  A sourcebook.
Y1  - 1979///
SP  - 234
EP  - 242
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 0-912704-13-6
SN  - 0-912704-11-X
N1  - Accession Number: 1990-98082-023. Partial author list: First Author & Affiliation: Goldberg, Irving D.; National Institute of Mental Health, Biometry Branch, Evaluation Studies Section, Chevy Chase, MD, US. Release Date: 19900101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-13-6, Hardcover; 0-912704-11-X, Paperback. Language: English. Major Descriptor: Brief Psychotherapy; Health Care Utilization; Outpatient Treatment; Psychiatric Patients. Minor Descriptor: Health Insurance; Outpatients. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 9. 
AB  - This chapter is reprinted from MEDICAL CARE © J. B. Lippincott Company, 1970, 8, 419-428, by permission. A pilot study was conducted to measure the effect of a short-term outpatient psychiatric therapy benefit on the utilization of general medical services at Group Health Association of Washington, D.C. (GHA), a Prepaid group practice medical program. The study group consisted of 256 patients who were referred for such outpatient therapy and who were GHA members for a full 12-month period both before and after the psychiatric referral. Study patients experienced a marked reduction during the year after referral as compared with the prior year in the utilization of GHA nonpsychiatric physician services and laboratory or x-ray procedures. The reduction in number of patients seen was 13.6 per cent for nonpsychiatric physician services, and 75.7 per cent for laboratory or x-ray procedures. In terms of visits made, reduction was approximately 30 per cent for each of these services. Basic finding of reduced utilization was still obtained when factors of age, race, sex, psychiatric diagnosis, and number of therapy sessions attended under benefit were taken into account. Results support findings of reduced utilization in other studies and suggest more efficient utilization of appropriate medical services as a result of short-term outpatient mental health benefits in prepaid health plan settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brief psychiatric therapy
KW  - outpatient therapy
KW  - medical service utilization
KW  - prepaid health plan subscribers
KW  - 1979
KW  - Brief Psychotherapy
KW  - Health Care Utilization
KW  - Outpatient Treatment
KW  - Psychiatric Patients
KW  - Health Insurance
KW  - Outpatients
KW  - 1979
DO  - 10.1037/10070-023
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 1990-98082-033
AN  - 1990-98082-033
AU  - Liptzin, Benjamin
AU  - Stockdill, James W.
AU  - Brown, Bertram S.
ED  - Kiesler, Charles A.
ED  - Cummings, Nicholas A.
ED  - VandenBos, Gary R.
ED  - Kiesler, Charles A., (Ed)
ED  - Cummings, Nicholas A., (Ed)
ED  - VandenBos, Gary R., (Ed)
T1  - A federal view of mental health program evaluation.
T2  - Psychology and national health insurance:  A sourcebook.
Y1  - 1979///
SP  - 314
EP  - 320
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 0-912704-13-6
SN  - 0-912704-11-X
N1  - Accession Number: 1990-98082-033. Partial author list: First Author & Affiliation: Liptzin, Benjamin; National Institute of Mental Health, Office of Program Development and Analysis, Program Analysis and Evaluation Branch, Rockville, MD, US. Release Date: 19900101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. ISBN: 0-912704-13-6, Hardcover; 0-912704-11-X, Paperback. Language: English. Major Descriptor: Community Mental Health Centers; Government Agencies; Mental Health Program Evaluation; Mental Health Programs. Minor Descriptor: Management Decision Making; Politics; Quality Control; Quality of Care; Quality of Services. Classification: Health & Mental Health Services (3370). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 7. 
AB  - This chapter is reprinted from Professional Psychology, 1977, 8, 543-552. This article discusses the current thinking at the National Institute of Mental Health on what evaluation is, who it is directed to, how it can be used, and what other activities relate to it. The article discusses the sections of the Community Mental Health Centers Amendments of 1975 that relate to program evaluation, quality assurance, and standards. The relationship of quality assurance activities to private office practice is also addressed. Evaluation is discussed in relation to decision making from two points of view: political and management. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - National Institute of Mental Health
KW  - mental health program evaluation
KW  - community mental health centers
KW  - quality assurance
KW  - political decision making
KW  - management decision making
KW  - 1979
KW  - Community Mental Health Centers
KW  - Government Agencies
KW  - Mental Health Program Evaluation
KW  - Mental Health Programs
KW  - Management Decision Making
KW  - Politics
KW  - Quality Control
KW  - Quality of Care
KW  - Quality of Services
KW  - 1979
DO  - 10.1037/10070-033
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Chang, Lana Fourshee
AU  - Chang, Lana Foushee
T1  - HOW TO SUCCEED WITH WET-TO-DRY DRESSINGS.
JO  - RN
JF  - RN
Y1  - 1979/01//
VL  - 42
IS  - 1
M3  - Article
SP  - 63
EP  - 66
SN  - 00337021
AB  - Presents guidelines for nurses on applying wet-to-dry dressings.  Function of wet-to-dry dressings to debride the wound; Step-by-step guide to proper procedure; Selection of the right type of solution used to soak the dressing.  INSET: WET-TO-DRY DRESSINGS: Step-by-Step guide to proper....
KW  - SURGICAL dressings
KW  - WOUNDS & injuries -- Treatment
N1  - Accession Number: 4878721; Chang, Lana Fourshee; Chang, Lana Foushee 1; Source Information: Jan79, Vol. 42 Issue 1, p63; Subject: SURGICAL dressings; Subject: WOUNDS & injuries -- Treatment; Number of Pages: 4p; Illustrations: 10 Black and White Photographs; Document Type: Article; Full Text Word Count: 1694
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Doszkocs, Tamas E
AU  - Rapp, Barbara A
T1  - Searching medline in english: a prototype user interface with natural language query, ranked output, and relevance feedback
JO  - Searching medline in english: a prototype user interface with natural language query, ranked output, and relevance feedback
JF  - Searching medline in english: a prototype user interface with natural language query, ranked output, and relevance feedback
Y1  - 1979///
M3  - Book
AB  - Developing an english sentence (natural language) query capability for today's operational online retrieval systems promises to have profound impact on bibliographical retrieval. Althouth much research has been done over the past two decades, experimental systems have not been implemented in a large operational environment. In a prototype system called cite (current information transfer in english), the authors have demonstrated a technical solution for implementing an operational natural language interface to medline, the most heavily used of nlm's 19 data bases. Important in the design of the system were the functional considerations of: identification of search terms; combinatorial searching; weighting and ranked output; relevance feedback; and automatic query modification. Technical considerations focused on maintenance of quick response time and internal efficiency. Of critical importance was the solution of the technical problems of 1) merging postings lists to achieve the logical equivalent of combinatorial searching and 2) computing document ranking weights. The principles employed in the system design are of a general nature and can be transferres to any inverted file system
N1  - Accession Number: ISTA1500490; Doszkocs, Tamas E 1; Rapp, Barbara A 2; Affiliations: 1 : National Cancer Institute; 2 : Nlm;  Source Info: 1979; Note: Update Code: 1500; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2013-42954-003
AN  - 2013-42954-003
AU  - Davenport, Yolande B.
AU  - Adland, Marvin L.
AU  - Gold, Philip W.
AU  - Goodwin, Frederick K.
T1  - Manic-depressive illness: Psychodynamic features of multigenerational families.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1979/01//
VL  - 49
IS  - 1
SP  - 24
EP  - 35
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Davenport, Yolande B., Unit on Family Studies, Clinical Psychobiology Branch, NIMH, Clinical Center, Room 4S-239, Bethesda, MD, US, 20014
N1  - Accession Number: 2013-42954-003. PMID: 758801 Partial author list: First Author & Affiliation: Davenport, Yolande B.; Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Psychodynamics; Self-Esteem. Minor Descriptor: Family; Fear; Heritability; Intergenerational Relations. Classification: Affective Disorders (3211); Psychoanalytic Therapy (3315). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Tests & Measures: Hollingshead-Redlich Scale. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jan, 1979. Copyright Statement: American Orthopsychiatric Association, Inc. 1979. 
AB  - Psychodynamic features of families with multigenerational bipolar manic-depressive illness are described. Repetitive maladaptive patterns, including avoidance of affect, unrealistic standards of conformity, absence of intimate relationships apart from family, displaced parental low self-esteem, and fears related to illness heritability, may influence the maintenance of family pathology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - manic depressive illness
KW  - psychodynamic features
KW  - multigenerational families
KW  - self esteem
KW  - fears
KW  - 1979
KW  - Bipolar Disorder
KW  - Psychodynamics
KW  - Self-Esteem
KW  - Family
KW  - Fear
KW  - Heritability
KW  - Intergenerational Relations
KW  - 1979
DO  - 10.1111/j.1939-0025.1979.tb02582.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42954-010
AN  - 2013-42954-010
AU  - Goldstein, Carole G.
AU  - Koopman, Elizabeth J.
AU  - Goldstein, Harold H.
T1  - Racial attitudes in young children as a function of interracial contact in the public schools.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1979/01//
VL  - 49
IS  - 1
SP  - 89
EP  - 99
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Goldstein, Harold H., Staff College, National Institute of Mental Health, 5635 Fishers Lane, Rockville, MD, US, 20852
N1  - Accession Number: 2013-42954-010. PMID: 758808 Partial author list: First Author & Affiliation: Goldstein, Carole G.; Institute for Child Study, University of Maryland, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blacks; Public School Education; Racial and Ethnic Attitudes; Racial and Ethnic Relations; Student Attitudes. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Show Me Test; Racial Stereotyping Test. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jan, 1979. Copyright Statement: American Orthopsychiatric Association, Inc. 1979. 
AB  - The relative effects of integrated and segregated schooling on racial attitudes were studied in a comparison of young children attending all-black, all-white, and integrated schools. Results of this photo-choice study suggest that segregated classes discourage realistic perceptions of the excluded race and promote a preference for whites among whites and blacks, whereas interracial schooling contributes to acceptance of blacks by all students and has especially profound and complex effects on black children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - racial attitudes
KW  - interracial contacts
KW  - public schools
KW  - Black children
KW  - 1979
KW  - Blacks
KW  - Public School Education
KW  - Racial and Ethnic Attitudes
KW  - Racial and Ethnic Relations
KW  - Student Attitudes
KW  - 1979
DO  - 10.1111/j.1939-0025.1979.tb02589.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42954-026
AN  - 2013-42954-026
AU  - Shore, Milton F.
T1  - Review of Too great expectations: The academic outlook of young children.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1979/01//
VL  - 49
IS  - 1
SP  - 181
EP  - 182
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42954-026. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Academic Achievement; Aspiration Level; School Environment. Minor Descriptor: Elementary School Students; Expectations; Lower Class. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Reviewed Item: Entwisle, Doris R.; Hayduk, Leslie A. Too great expectations: The academic outlook of young children=193 pp. $12.95. John Hopkins University Press, Baltimore; 1978. Page Count: 2. Issue Publication Date: Jan, 1979. 
AB  - Reviews the book, Too great expectations: The Academic Outlook of Young Children by Doris R. Entwisle and Leslie A. Hayduk (1978). The authors have carried out a large sociological study of two cohorts of school children from the first grade of two schools in the city of Baltimore, Maryland-one in a lower-class area and the other in a middle-class area. Some of the findings are of interest. The authors found that all first-grade children predicted extremely high grades. Their predictions were more unrealistic than those of their parents. The authors are appropriately concerned with the effect on lower-class children of negative feedback in school. They wish to intervene in the schools to assist lower-class children. But is it best to reduce lower-class children's aspiration level to match outcome as measured by grades, as the authors suggest? Or is it more appropriate to alter the total educational approach to these children? The greatest failing of this work is suggested by its own title-the authors' too great expectations of their data. One needs to be concerned with school settings, and expectations are important. But believing that expectations as measured by grades, received or predicted, will be the panacea for all academic difficulties in lower-class children is certainly not warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - academic outlook
KW  - young children
KW  - lower class children
KW  - school settings
KW  - aspiration level
KW  - 1979
KW  - Academic Achievement
KW  - Aspiration Level
KW  - School Environment
KW  - Elementary School Students
KW  - Expectations
KW  - Lower Class
KW  - 1979
U2  - Entwisle, Doris R.; Hayduk, Leslie A. (1978); Too great expectations: The academic outlook of young children; 193 pp. $12.95. John Hopkins University Press, Baltimore
DO  - 10.1037/h0098872
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-05560-001
AN  - 2009-05560-001
AU  - Usdin, Eari
T1  - 'Endorphins, dopamine, and schizophrenia': Two discussions: II.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1979///
VL  - 5
IS  - 2
SP  - 242
EP  - 243
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Usdin, Eari, Pharmacology Section, Psychopharmacology Research Branch, Rm. 9-95, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2009-05560-001. Partial author list: First Author & Affiliation: Usdin, Eari; Pharmacology Section, Psychopharmacology Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Dopamine; Etiology; Neurochemistry; Peptides; Schizophrenia. Minor Descriptor: Endorphins. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 2. Issue Publication Date: 1979. 
AB  - Comments on the original article 'Endorphins, dopamine, and schizophrenia,' by J. Volavka, L. G. Davis, and Y. H. Ehrlich (see record [rid]1981-12979-001[/rid]). Although studies using endorphins may well prove valuable in our understanding of the etiology of schizophrenia and may even lead to new and effective psychotherapeutic agents, this discussant concludes that it is premature to suggest that either beta-endorphin or an analogue has been demonstrated to be an antipsychotic agent. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - endorphin system alteration
KW  - dopaminergic neuronal hyperactivity
KW  - etiology
KW  - schizophrenia
KW  - 1979
KW  - Dopamine
KW  - Etiology
KW  - Neurochemistry
KW  - Peptides
KW  - Schizophrenia
KW  - Endorphins
KW  - 1979
DO  - 10.1093/schbul/5.2.242
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-05554-001
AN  - 2009-05554-001
AU  - Matthews, Susan M.
AU  - Mosher, Loren R.
AU  - Roper, Margaret T.
AU  - Menn, Alma Z.
T1  - 'Non-neuroleptic treatment for schizophrenia': The authors reply.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1979///
VL  - 5
IS  - 4
SP  - 566
EP  - 567
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Matthews, Susan M., Center for Studies of Schizophrenia National Institute of Mental Health, Rockville, MD, US, 20857
N1  - Accession Number: 2009-05554-001. Partial author list: First Author & Affiliation: Matthews, Susan M.; Center for Studies of Schizophrenia, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Neuroleptic Drugs; Schizophrenia; Treatment Effectiveness Evaluation. Minor Descriptor: Psychiatric Hospital Discharge; Relapse (Disorders); Therapeutic Community. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: 1979. 
AB  - Responds to the comments by A. Rifkin (see record [rid]2009-05555-001[/rid]) on the current authors' original article (see record [rid]1981-13171-001[/rid]). The authors address the five major points raised by Rifkin: (1) Sample selection; (2) Criteria for rehospitalization; (3) The findings of Klein and Rosen (1973); (4) The meaning of 'purely clinical' decision; and (5) Relapse rates and selection criteria. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuroleptic vs intensive psychosocial milieu treatment
KW  - relapse
KW  - residential care discharge
KW  - first-admission schizophrenics
KW  - 1979
KW  - Drug Therapy
KW  - Neuroleptic Drugs
KW  - Schizophrenia
KW  - Treatment Effectiveness Evaluation
KW  - Psychiatric Hospital Discharge
KW  - Relapse (Disorders)
KW  - Therapeutic Community
KW  - 1979
DO  - 10.1093/schbul/5.4.566
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SHINOHARA, MAMI
AU  - DOLLINGER, BETH
AU  - BROWN, GWEN
AU  - RAPOPORT, STANLEY
AU  - SOKOLOFF, Louis
T1  - Cerebral Glucose Utilization: Local Changes During and After Recovery from Spreading Cortical Depression.
JO  - Science
JF  - Science
Y1  - 1979/01/12/
VL  - 203
IS  - 4376
M3  - Article
SP  - 188
EP  - 190
SN  - 00368075
AB  - Cerebral glucose utilization is markedly increased in most areas of the cerebral cortex and reduced in many subcortical structures during spreading cortical depression. During recovery, cortical glucose utilization is still elevated, but the increased metabolic activity is distributed in columns running perpendicularly through the cortex. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85218894; SHINOHARA, MAMI 1; DOLLINGER, BETH 1; BROWN, GWEN 1; RAPOPORT, STANLEY 2; SOKOLOFF, Louis 3; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neurosciences, National Institute of Aging, Baltimore, Maryland 21224; 3: Laboratory of Cerebral Metabolism, National Institute of Mental Health; Issue Info: 1/12/1979, Vol. 203 Issue 4376, p188; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VANDENBURGH, HERMAN
AU  - KAUFMAN, SEYMOUR
T1  - In vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle.
JO  - Science
JF  - Science
Y1  - 1979/01/19/
VL  - 203
IS  - 4377
M3  - Article
SP  - 265
EP  - 268
SN  - 00368075
AB  - Mechanical stretch of embryonic chicken skeletal myotubes developed in vitro leads to many of the biochemical changes seen in skeletal muscle hypertrophy. These include increased amino acid accumulation, increased incorporation of amino acids into general cellular proteins and myosin heavy chains, and increased accumulation of total protein and myosin heavy chains. This model system should aid in understanding how the growth rate of skeletal muscle is regulated by its activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268674; VANDENBURGH, HERMAN 1; KAUFMAN, SEYMOUR 1; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/19/1979, Vol. 203 Issue 4377, p265; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ZATZ, MARTIN
AU  - BROWNSTEIN, MICHAEL J.
T1  - Intraventricular Carbachol Mimics the Effects of Light on the Circadian Rhythm in the Rat Pineal Gland.
JO  - Science
JF  - Science
Y1  - 1979/01/26/
VL  - 203
IS  - 4378
M3  - Article
SP  - 358
EP  - 361
SN  - 00368075
AB  - Environmental lighting regulates numerous circadian rhythms, including the cycle in pineal serotonin N-acetyltransferase activity. Brief exposure of rats to light can shift the phase of this enzyme's circadian rhythm. Light also rapidly reduces nocturnal enzyme activity. Intraventricular injections of carbachol, a cholinergic agonist, can mimic both of these effects. Light and carbachol presumably act on the suprachiasmatic nucleus of the hypothalamus. These experiments demonstrate the feasibility of using a neuropharmacologic approach to the mechanisms underlying mammalian circadian rhythms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361475; ZATZ, MARTIN 1; BROWNSTEIN, MICHAEL J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/26/1979, Vol. 203 Issue 4378, p358; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DURAN, ANGEL
AU  - CABIB, ENRICO
AU  - BOWERS, BLAIR
T1  - Chitin Synthetase Distribution on the Yeast Plasma Membrane.
JO  - Science
JF  - Science
Y1  - 1979/01/26/
VL  - 203
IS  - 4378
M3  - Article
SP  - 363
EP  - 365
SN  - 00368075
AB  - Purified, intact yeast plasma membranes were allowed to synthesize chitin, and the nascent chains of polysaccharide were observed either by the fluorescence produced with a brightener or by autoradiography. By both methods, it was concluded that the newly formed chitin emerged at many sites on each membrane. Thus, the synthetase that catalyzes chitin formation has a similar distribution. Since chitin synthetase is found mainly in a zymogen form, these results confirm the hypothesis that initiation of the chitinous primary septum of Saccharomyces occurs by localized activation of the uniformly distributed zymogen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361477; DURAN, ANGEL 1; CABIB, ENRICO 1; BOWERS, BLAIR 2; Affiliations: 1: National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; 2: National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 1/26/1979, Vol. 203 Issue 4378, p363; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Boice, John D.
AU  - Land, Charles E.
T1  - Adult Leukemia Following Diagnostic X-Rays?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1979/02//
VL  - 69
IS  - 2
M3  - Article
SP  - 137
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the study on adult leukemia following diagnostic x-rays. According to the study, the association between leukemia and diagnostic x-ray may be entirely due to a few individuals who received massive diagnostic radiation exposures. The study has showed that several researches linking diagnostic radiation with adult non-lymphocytic leukemia have been reported in England, New Zealand and the U.S. Each of the researches have reported an association in adults between diagnostic x-rays and myeloid leukemia, but not lymphatic leukemia.
KW  - PUBLIC health research
KW  - ADULT T-cell leukemia
KW  - LYMPHOCYTIC leukemia
KW  - MYELOID leukemia
KW  - X-rays
KW  - RADIATION exposure
KW  - RADIOISOTOPES in medical diagnosis
KW  - MEDICAL research
KW  - MEDICAL technology
N1  - Accession Number: 6009224; Boice, John D. 1 Land, Charles E. 1; Affiliation:  1: Environmental Epidemiology Branch, National Cancer Institute.; Source Info: Feb1979, Vol. 69 Issue 2, p137; Subject Term: PUBLIC health research; Subject Term: ADULT T-cell leukemia; Subject Term: LYMPHOCYTIC leukemia; Subject Term: MYELOID leukemia; Subject Term: X-rays; Subject Term: RADIATION exposure; Subject Term: RADIOISOTOPES in medical diagnosis; Subject Term: MEDICAL research; Subject Term: MEDICAL technology; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Miles, F. A.
AU  - Evarts, E. V.
T1  - CONCEPTS OF MOTOR ORGANIZATION.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1979/02//
VL  - 30
IS  - 1
M3  - Article
SP  - 327
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11265210; Miles, F. A. 1 Evarts, E. V. 1; Affiliation:  1: Laboratory of  Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014.; Source Info: 1979, Vol. 30 Issue 1, p327; Number of Pages: 36p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zopi, David A.
AU  - Ginsburg, Victor
AU  - Hallgren, Peter
AU  - Jonsson, Anne-Charlotte
AU  - Lindbi, Bo S.
AU  - Arne Lundbland
T1  - Determination of Leb-Active Oligosaccharides in Urine of Pregant and Lactating Women by Radioimmunoassay.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1979/02//2/1/79
VL  - 93
IS  - 3
M3  - Article
SP  - 431
EP  - 435
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Antiserum obtained by immunizing a goat with lacto-N-difucohexaose L a Leb blood-grouphapten. coupled to poly-L-lysine was used in a radioimmunoassay to detect Leb-active oligosaccharides (chiefly lacto-N-difucohexaose I) in urine of 138 pregnant and lactating women of different ABO and Lewis blood groups. Specificity of the method was determined by comparing inhibitory activities of 18 oligosaccharides. Only women who belonged to the Leb blood group excreted Leb-active oligosaccharides in urine. Leb-active oligosaccharides increase during pregnancy reaching levels up to approximately 70 μmol lacto-N-difucohexaose I equivalents per pmol creatinine in the third trimester and early post-partum period. Excretion varies considerable but tends to be highest in those individuals who strongly express the Leb antigen on their red blood cells or who belong to blood group O. Leb-active oligosaccharides were detected in plasma of a few individuals but at concentrations 1000-fold lower than in urine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXAMINATION of the blood
KW  - OLIGOSACCHARIDES
KW  - EXCRETION
KW  - BLOOD transfusion
KW  - PHYSIOLOGY
KW  - BLOOD cells
N1  - Accession Number: 13603837; Zopi, David A. 1 Ginsburg, Victor 1,2,3 Hallgren, Peter 1,2,3 Jonsson, Anne-Charlotte 1,2,3 Lindbi, Bo S. 1,2,3 Arne Lundbland 1,2,3; Affiliation:  1: National Cancer Institute and National Institute of Arthrus, Metabolism and Digestive Diseases National Institutes of Health, Bethesda, Maryland.  2: Department of Clinical Chemistry, University Hospital, Lund.  3: Department of Obstetrics and Gynecology, Central Hospital, Central Hospital, Vasteras.; Source Info: 2/1/79, Vol. 93 Issue 3, p431; Subject Term: EXAMINATION of the blood; Subject Term: OLIGOSACCHARIDES; Subject Term: EXCRETION; Subject Term: BLOOD transfusion; Subject Term: PHYSIOLOGY; Subject Term: BLOOD cells; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KABAT, ELVIN A.
T1  - Antibody Gene Structure.
JO  - Science
JF  - Science
Y1  - 1979/02/02/
VL  - 203
IS  - 4379
M3  - Article
SP  - 400
EP  - 400
SN  - 00368075
N1  - Accession Number: 85268686; KABAT, ELVIN A. 1,2; Affiliations: 1: Departments of Microbiology, Human Genetics and Development, and Neurobiology, Columbia University, New York 10032; 2: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 2/1979, Vol. 203 Issue 4379, p400; Number of Pages: 1/3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WOLPAW, JONATHAN R.
T1  - Electromagnetic Muscle Stretch Strongly Excites Sensorimotor Cortex Neurons in Behaving Primates.
JO  - Science
JF  - Science
Y1  - 1979/02/02/
VL  - 203
IS  - 4379
M3  - Article
SP  - 465
EP  - 467
SN  - 00368075
AB  - Responses of single units in primary motor and sensory cortex of behaving primates to electromagnetic stretch of the muscle flexor carpi ulnaris are comparable in latency and intensity to responses to wrist extension. Thus, muscle stretch appears to be a major factor in cortical response to limb displacement during performance and probably has an important role in motor control at the cortical level. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268725; WOLPAW, JONATHAN R. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/ 2/1979, Vol. 203 Issue 4379, p465; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - ENQUIST, L. W.
AU  - MADDEN, M. J.
AU  - SCHIOP-STANSLY, P.
AU  - WOUDE, G. F. VANDE
T1  - Cloning of Herpes Simplex Type 1 DNA Fragments in a Bacteriophage Lambda Vector.
JO  - Science
JF  - Science
Y1  - 1979/02/09/
VL  - 203
IS  - 4380
M3  - Article
SP  - 541
EP  - 544
SN  - 00368075
AB  - DNA isolated from defective and nondefective virions of herpes simplex type I (HSV-J) (strain Patton) was digested with restriction endonucleases, and the resulting DNA fragments were inserted in the EK2 coliphage vector AgtWES XB. The recombinant DNA was encapsidated in vitro under P4 maximum containment conditions. These X-HSVI hybrids were purified and amplified, and the DNA was isolated in the P4 facility. DNA, free of viable phage and bacteria, was removed from P4 conditions and analyzed. Represented among the hybrids studied to date are DNA fragments from about 50 percent of the normal HSV-1 genome. The hybrids derived from defective HSV-I DNAfragments demonstrate the existence of many similar but not identical classes of defective genomes. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268760; ENQUIST, L. W. 1; MADDEN, M. J. 1; SCHIOP-STANSLY, P. 1; WOUDE, G. F. VANDE 1; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p541; Number of Pages: 4p; Document Type: Article
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TY  - JOUR
AU  - HARRISON, LEN C.
AU  - FLIER, JEFFREY
AU  - ITIN, AHUVA
AU  - KAHN, C. RONALD
AU  - ROTH, JESSE
T1  - Radioimmunoassay of the Insulin Receptor: A New Probe of Receptor Structure and Function.
JO  - Science
JF  - Science
Y1  - 1979/02/09/
VL  - 203
IS  - 4380
M3  - Article
SP  - 544
EP  - 547
SN  - 00368075
AB  - A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lvmphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268761; HARRISON, LEN C. 1; FLIER, JEFFREY 1; ITIN, AHUVA 1; KAHN, C. RONALD 1; ROTH, JESSE 1; Affiliations: 1: Diabetes Branch, National Institute of Arthritis, Metabolism, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p544; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - DRISCOLL, BERNARD F.
AU  - KIES, MARIAN W.
AU  - ALVORD JR., ELLSWORTH C.
T1  - Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells.
JO  - Science
JF  - Science
Y1  - 1979/02/09/
VL  - 203
IS  - 4380
M3  - Article
SP  - 547
EP  - 548
SN  - 00368075
AB  - Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 107 cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268762; DRISCOLL, BERNARD F. 1; KIES, MARIAN W. 1; ALVORD JR., ELLSWORTH C. 2; Affiliations: 1: Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Neuropathology RJ-05, University of Washington, School of Medicine, Seattle 98195; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p547; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WYATT, RICHARD G.
AU  - MEBUS, CHARLES A.
AU  - YOLKEN, ROBERT H.
AU  - KALICA, ANTHONY R.
AU  - JAMES JR., HARVEY D.
AU  - KAPIKIAN, ALBERT Z.
AU  - CHANOCK, ROBERT M.
T1  - Rotaviral Immunity in Gnotobiotic Calves: Heterologous Resistance to Human Virus Induced by Bovine Virus.
JO  - Science
JF  - Science
Y1  - 1979/02/09/
VL  - 203
IS  - 4380
M3  - Article
SP  - 548
EP  - 550
SN  - 00368075
AB  - The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85268763; WYATT, RICHARD G. 1; MEBUS, CHARLES A. 2; YOLKEN, ROBERT H. 3; KALICA, ANTHONY R. 3; JAMES JR., HARVEY D. 3; KAPIKIAN, ALBERT Z. 3; CHANOCK, ROBERT M. 3; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Plum Island Animal Disease Center, Greenport, New York 11944; 3: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p548; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DE SERRES, FREDERICK J.
AU  - SHELBY, MICHAEL D.
T1  - The Salmonella Mutagenicity Assay: Recommendations.
JO  - Science
JF  - Science
Y1  - 1979/02/09/
VL  - 203
IS  - 4380
M3  - Article
SP  - 563
EP  - 565
SN  - 00368075
N1  - Accession Number: 85268770; DE SERRES, FREDERICK J. 1; SHELBY, MICHAEL D. 1; Affiliations: 1: Office of the Associate Director for Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p563; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Pitha, Josef
AU  - Kociolek, Karol
AU  - Caron, Marc G.
T1  - Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1979/02/15/
VL  - 94
IS  - 1
M3  - Article
SP  - 11
EP  - 18
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Residues of Triton X-100 [C8H17-C6H4-(O-CH2-CH2)9-10-O-] were bound by ether bonds to inulin, dextran, amylose, and cellulose-yielding compounds containing 10- 30, 5, 19 and 6% (w/w) of Triton X-100 residue respectively. The water-soluble inulin derivative was studied in detail. This compound was fractionated on the basis of molecular weight by gel chromatography and on the basis of degree of substitution by adsorption to polystyrene resin. Even the residues of Triton X-100 which were bound to a single inulin macromolecule were able to form a micelle; in addition to these monomolecular micelles the inulin derivative was able to form polymolecular micelles as well. The inulin derivative was effective in solubilizing proteins and phospholipids from membranes of human erythrocytes and liberated reverse transcriptase activity from the membrane-enveloped virions of murine leukemia. The Triton X-100 inulin derivative abolished binding of the ³H-labelled antagonist dihydroalprenolol to solubilized preparations of β-adrenergic receptors from frog erythrocytes in a dose-related manner similar to the inactivation produced by Triton X-100, while digitonin, a detergent containing a bulkier hydrophobic group, did not cause inactivation. On the basis of its Triton X-100 content, the inulin derivative was found to be less detrimental to the growth of murine erythroleukemic cells in vitro than Triton X-100 alone when short (2-4 h) exposures were used, but this difference disappeared at longer (1-3 day) exposures. Results thus suggest that the increase in size of the hydrophilic part of the detergent brings about moderation in those effects of the detergent which are dependent on the rate of diffusion, while the solubilizing and inactivating effects of the detergent were not changed. It is probably the size of the hydrophobic part which is important in protein-inactivating properties of the detergent. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POLYSACCHARIDES
KW  - CARBOHYDRATES
KW  - LEUKEMIA
KW  - CLEANING compounds
KW  - PROTEINS
KW  - CANCER
KW  - LABELING
N1  - Accession Number: 13605068; Pitha, Josef 1 Kociolek, Karol 2 Caron, Marc G. 3; Affiliation:  1: Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland.  2: Baltimore City Hospitals, Baltimore, Maryland.  3: Department of Medicine, Duke University Medical Center, Durham, North Carolina.; Source Info: 2/15/79, Vol. 94 Issue 1, p11; Subject Term: POLYSACCHARIDES; Subject Term: CARBOHYDRATES; Subject Term: LEUKEMIA; Subject Term: CLEANING compounds; Subject Term: PROTEINS; Subject Term: CANCER; Subject Term: LABELING; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - HOOPER, N. KIM
AU  - HARRIS, ROBERT H.
AU  - AMES, BRUCE N.
AU  - SCHNEIDERMAN, MARVIN A.
AU  - WEIGERT, FRANK J.
T1  - Chemical Carcinogens.
JO  - Science
JF  - Science
Y1  - 1979/02/16/
VL  - 203
IS  - 4381
M3  - Article
SP  - 602
EP  - 603
SN  - 00368075
N1  - Accession Number: 85199289; HOOPER, N. KIM 1; HARRIS, ROBERT H. 1; AMES, BRUCE N. 1; SCHNEIDERMAN, MARVIN A. 2; WEIGERT, FRANK J.; Affiliations: 1: Department of Biochemistry, University of California, Berkeley 94720; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 2/16/1979, Vol. 203 Issue 4381, p602; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - GAION, ROSA MARIA
AU  - KRISHNA, GOPAL
AU  - IGNARRO, LOUIS J.
T1  - Cytidylate Cyclase: Possible Artifacts in the Methodology.
JO  - Science
JF  - Science
Y1  - 1979/02/16/
VL  - 203
IS  - 4381
M3  - Article
SP  - 672
EP  - 673
SN  - 00368075
N1  - Accession Number: 85199323; GAION, ROSA MARIA 1; KRISHNA, GOPAL 1; IGNARRO, LOUIS J. 2; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112; Issue Info: 2/16/1979, Vol. 203 Issue 4381, p672; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - MOORE, JOHN A.
T1  - A Pesticide.
JO  - Science
JF  - Science
Y1  - 1979/02/23/
VL  - 203
IS  - 4382
M3  - Article
SP  - 741
EP  - 742
SN  - 00368075
N1  - Accession Number: 85199360; MOORE, JOHN A. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 2/23/1979, Vol. 203 Issue 4382, p741; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Hollenbeck, Albert R.
AU  - Slaby, Ronald G.
T1  - Infant Visual and Vocal Responses to Television.
JO  - Child Development
JF  - Child Development
Y1  - 1979/03//
VL  - 50
IS  - 1
M3  - Article
SP  - 41
EP  - 45
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12432787; Hollenbeck, Albert R. 1 Slaby, Ronald G. 2; Affiliation:  1: National Institute of Mental Health  2: University of Washington; Source Info: Mar1979, Vol. 50 Issue 1, p41; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1467-8624.ep12432787
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ER  - 

TY  - JOUR
AU  - Faith, R. E.
AU  - Luster, M. I.
AU  - Kimmel, Carole A.
T1  - Effect of chronic developmental lead exposure on cell- mediated immune functions.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1979/03//
VL  - 35
IS  - 3
M3  - Article
SP  - 413
EP  - 420
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Studies were performed to investigate the effects of chronic, low level pre- and post-natal lead exposure on cell-mediated immune function in rats. Weanling female rats were exposed to lead (as lead acetate) in their drinking water at 0, 25, and 50 ppm for 7 weeks. At the end of 7 weeks they were mated with untreated males and continued on the same dosage throughout gestation and lactation. The offspring of these females were weaned at 21 days of age and continued on the same lead exposure regimen as their mothers. These offspring were used in immune surveillance procedures between 35 and 45 days of age. Lead exposure at the levels employed had no statistically significant effect on growth anti did not result in overt signs of toxicity. Thymic weights were significantly decreased in both males and females of the two lead dosage groups. Furthermore, lead exposure resulted in suppression of responsiveness of lymphocytes to mitogen stimulation and in reduced delayed hypersensitivity responsiveness. Results indicate that chronic low-level lead exposure causes suppression of cell mediated immune function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHRONIC diseases
KW  - IMMUNE system
KW  - IMMUNOLOGIC diseases
KW  - LEAD -- Toxicology
KW  - LEUCOCYTES
KW  - CELLULAR immunity
N1  - Accession Number: 15987750; Faith, R. E. 1 Luster, M. I. 1 Kimmel, Carole A. 1; Affiliation:  1: Environmental Biology and Chemistry Branch and Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences, USA.; Source Info: Mar1979, Vol. 35 Issue 3, p413; Subject Term: CHRONIC diseases; Subject Term: IMMUNE system; Subject Term: IMMUNOLOGIC diseases; Subject Term: LEAD -- Toxicology; Subject Term: LEUCOCYTES; Subject Term: CELLULAR immunity; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Nelson, D. L.
AU  - Poplack, D. G.
AU  - Holiman, Betty J.
AU  - Henkart, P. A.
T1  - ADCC against human erythrocyte target cells: role of the anti-target cell antibodies in determining lymphocyte killer activity.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1979/03//
VL  - 35
IS  - 3
M3  - Article
SP  - 447
EP  - 453
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Studies were undertaken to investigate the role of anti-target cell antibodies in determining whether lymphocytes can mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro. Trinitrophenyl (TNP) modified Chang liver cells and human erythrocytes were employed as target cells and were coated with xenogeneic and allogeneic antibodies against TNP and natural cell surface antigens. Two cytotoxic effector cell populations were used: human peripheral blood mononuclear cells (PBMC) containing both lymphocytes and monocytes, and monocyte depleted peripheral blood lymphocytes (PBL). With Chang targets, both PBMC and PBL mediated ADCC with xenogeneic anti-Chang and xenogeneic anti-TNP sera. With human erythrocyte targets, PBMC but not PBL mediated ADCC with human anti-blood group B serum, while both PBMC and PBL mediated ADCC with xenogeneic anti-TNP sera and also with ;i human anti-CD serum. These results demonstrate that the source of anti-target cell antibodies employed in ADCC reactions may determine whether or not lymphocytes are capable of mediating cytotoxicity. [ABSTRACT FROM AUTHOR]
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KW  - ERYTHROCYTES
KW  - LEUCOCYTES
KW  - BLOOD cells
KW  - IMMUNOGLOBULINS
KW  - LYMPHOCYTES
KW  - KILLER cells
N1  - Accession Number: 15987899; Nelson, D. L. 1 Poplack, D. G. 1 Holiman, Betty J. 1 Henkart, P. A. 1; Affiliation:  1: Metabolism, Pediatric Oncology and Immunology Branches of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.; Source Info: Mar1979, Vol. 35 Issue 3, p447; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Subject Term: BLOOD cells; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: KILLER cells; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Grummt, Ingrid
AU  - Hall, Stanton H.
AU  - Crouch, Robert J.
T1  - Localisation of an Endonuclease Specific for Double-Stranded RNA within the Nucleolus and Its Implication in Processing Ribosomal Transcripts.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1979/03//3/1/79
VL  - 94
IS  - 2
M3  - Article
SP  - 437
EP  - 443
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Nucleoli of both chick embryos and mouse Ehrlich ascites cells contain an enzymatic activity that is very similar to RNase DII, an enzyme isolated from total chick embryos for its ability to degrade double-stranded RNA. The enzyme can be extracted by low salt/EDTA from nucleoli and is associated with pre-ribosomal 80-S and 55-S particles. Under ionic conditions which are inhibitory for the nucleolytic activity the transcript in vitro of nucleoli is not processed and sediments around 45 S. Under salt conditions which are optimal for the nucleolar enzyme the nucleolar transcripts are cleaved to distinct intermediate-sized molecules. Addition of the chicken RNase DII or RNase III to the nucleolar transcription system results in a similar shift of the chain length of the RNA molecules. It is concluded that a nucleolar RNase recognizing double-stranded regions in the pre-ribosomal RNA is involved in the maturation of ribosomal RNA. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDONUCLEASES
KW  - RNA
KW  - NUCLEOLUS
KW  - RIBOSOMES
KW  - GENETIC transcription
KW  - BIOCHEMISTRY
N1  - Accession Number: 13607257; Grummt, Ingrid 1 Hall, Stanton H. 1 Crouch, Robert J. 1; Affiliation:  1: Max-Planck-Institut für Biochemie, Martinsried bei Münchem, and Section on Molecular Regulation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 3/1/79, Vol. 94 Issue 2, p437; Subject Term: ENDONUCLEASES; Subject Term: RNA; Subject Term: NUCLEOLUS; Subject Term: RIBOSOMES; Subject Term: GENETIC transcription; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Williams Jr., Redford B.
AU  - Eichelman, Burr S.
AU  - Ng, L. K. Y.
T1  - The Effects of Peripheral Chemosympathectomy and Adrenalectomy Upon Blood Pressure Responses of the Rat to Footshock Under Varying Conditions: Evidence for Behavioral Effects on Patterning of Sympathetic Nervous System Responses.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1979/03//
VL  - 16
IS  - 2
M3  - Article
SP  - 89
EP  - 93
SN  - 00485772
AB  - A significant decrease in blood pressure is observed after shock-induced fighting in intact rats. In rats treated with intravenous 6-hydroxydopamine, a drug that selectively destroys peripheral sympathetic nerve endings when given by this route, this blood pressure response is reversed to a significant increase. In contrast, adrenalectomy converts a slight increase in blood pressure after intact rats are shocked alone in the cage into a significant decrease. These alterations in blood pressure response suggest that the sympathetic response to a stressful stimulus is not an all or none response, but, rather, consists of a patterned activation depending upon the behavioral response available. The current physiological findings are consistent with neuroendocrine research in which coping behavior is found associated with a predominant norepinephrine release by the sympathetic nervous system, and stress without available coping responses is associated with release also of epinephrine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SHOCK (Mechanics)
KW  - BLOOD pressure
KW  - SYMPATHETIC nervous system
KW  - HYDROXYL group
KW  - DOPAMINE
KW  - ADRENALECTOMY
KW  - STRESS (Psychology)
KW  - NORADRENALINE
KW  - ADRENALINE
KW  - RATS
KW  - 6-hydroxydopamine
KW  - adrenalectomy
KW  - blood pressure response
KW  - coping
KW  - shock-induced fighting
KW  - sympathetic nervous system
N1  - Accession Number: 11192076; Williams Jr., Redford B. 1 Eichelman, Burr S. 1 Ng, L. K. Y. 1; Affiliation:  1: Laboratory of Clinical Psychobiology, National Institute of Mental Health.; Source Info: Mar1979, Vol. 16 Issue 2, p89; Subject Term: SHOCK (Mechanics); Subject Term: BLOOD pressure; Subject Term: SYMPATHETIC nervous system; Subject Term: HYDROXYL group; Subject Term: DOPAMINE; Subject Term: ADRENALECTOMY; Subject Term: STRESS (Psychology); Subject Term: NORADRENALINE; Subject Term: ADRENALINE; Subject Term: RATS; Author-Supplied Keyword: 6-hydroxydopamine; Author-Supplied Keyword: adrenalectomy; Author-Supplied Keyword: blood pressure response; Author-Supplied Keyword: coping; Author-Supplied Keyword: shock-induced fighting; Author-Supplied Keyword: sympathetic nervous system; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1469-8986.ep11192076
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ISRAEL, MARK A.
AU  - CHAN, HARDY W.
AU  - ROWE, WALLACE P.
AU  - MARTIN, MALCOLM A.
T1  - Molecular Cloning of Polyoma Virus DNA in Escherichia coli: Plasmid Vector System.
JO  - Science
JF  - Science
Y1  - 1979/03/02/
VL  - 203
IS  - 4383
M3  - Article
SP  - 883
EP  - 887
SN  - 00368075
AB  - A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or live Escherichia coli containing the recombinant plasmids, capable of inducing PY infection of mice, either by feeding or by parenteral injection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268797; ISRAEL, MARK A. 1; CHAN, HARDY W. 1; ROWE, WALLACE P. 2; MARTIN, MALCOLM A. 3; Affiliations: 1: DNA Recombinant Research Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases; 3: DNA Recombinant Research Unit; Issue Info: 3/ 2/1979, Vol. 203 Issue 4383, p883; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHAN, HARDY W.
AU  - ISRAEL, MARK A.
AU  - GARON, CLAUDE F.
AU  - ROWE, WALLACE P.
AU  - MARTIN, MALCOLM A.
T1  - Molecular Cloning of Polyoma Virus DNA in Escherichia coli: Lambda Phage Vector System.
JO  - Science
JF  - Science
Y1  - 1979/03/02/
VL  - 203
IS  - 4383
M3  - Article
SP  - 887
EP  - 892
SN  - 00368075
AB  - The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268798; CHAN, HARDY W. 1; ISRAEL, MARK A. 1; GARON, CLAUDE F. 2; ROWE, WALLACE P. 3; MARTIN, MALCOLM A. 4; Affiliations: 1: DNA Recombinant Research Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Laboratory of the Biology of Viruses; 3: Laboratory of Viral Diseases; 4: DNA Recombinant Research Unit; Issue Info: 3/ 2/1979, Vol. 203 Issue 4383, p887; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GRACELY, RICHARD H.
AU  - DUBNER, RONALD
AU  - MCGRATH, PATRICIA A.
T1  - Narcotic Analgesia: Fentanyl Reduces the Intensity but Not the Unpleasantness of Painful Tooth Pulp Sensations.
JO  - Science
JF  - Science
Y1  - 1979/03/23/
VL  - 203
IS  - 4386
M3  - Article
SP  - 1261
EP  - 1263
SN  - 00368075
AB  - Forty subjects rated the magnitude of painful electrical stimulation of tooth pulp before and after the intravenous administration of either fentanyl, a shortacting narcotic, or a saline placebo. The responses were choices of verbal descriptors from randomized lists of either sensory intensity (that is, weak, mild, intense) or unpleasantness (annoying, unpleasant, distressing) descriptors. The fentanyl significantly reduced the sensory intensity without reducing the unpleasantness of the tooth pulp stimuli, indicating that the mechanisms of narcotic analgesia may include a significant attenuation in pain sensation in addition to effects on pain reaction. These results stress the importance of using multiple measures of pain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199532; GRACELY, RICHARD H. 1; DUBNER, RONALD 1; MCGRATH, PATRICIA A. 1; Affiliations: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/23/1979, Vol. 203 Issue 4386, p1261; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - STETTEN JR., DEWITT
T1  - Microbial Containment.
JO  - Science
JF  - Science
Y1  - 1979/03/30/
VL  - 203
IS  - 4387
M3  - Article
SP  - 1292
EP  - 1292
SN  - 00368075
N1  - Accession Number: 85199544; STETTEN JR., DEWITT 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 3/30/1979, Vol. 203 Issue 4387, p1292; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WATERS, HAROLD
AU  - JAFFE, LIONEL F.
T1  - Grants: The Time Factor.
JO  - Science
JF  - Science
Y1  - 1979/03/30/
VL  - 203
IS  - 4387
M3  - Article
SP  - 1292
EP  - 1292
SN  - 00368075
N1  - Accession Number: 85199545; WATERS, HAROLD 1; JAFFE, LIONEL F. 2; Affiliations: 1: Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907; Issue Info: 3/30/1979, Vol. 203 Issue 4387, p1292; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Southwick, Charles H.
AU  - Blood, Benjamin D.
T1  - Conservation and Management of Wild Primate Populations.
JO  - BioScience
JF  - BioScience
Y1  - 1979/04//
VL  - 29
IS  - 4
M3  - Article
SP  - 233
EP  - 237
SN  - 00063568
AB  - The article presents information on the conservation and management of wild primate populations. It raises concerns over the rapid depletion of primates and mentions about their importance in the natural and cultural heritage of nations; in understanding human behavior, ecology, and evolution; and in solving problems of human health and disease. Manpower development provides training in primate ecology and management at both the scientific/professional and paraprofessional levels. It talks about primate conservation programs and obstacles to the conservation of ecosystems.
KW  - Zoogeography
KW  - Wildlife conservation
KW  - Ecosystem health
KW  - Biotic communities
KW  - Wildlife management
KW  - Wildlife management areas
KW  - Ecology
KW  - Primates
KW  - Animal population density
N1  - Accession Number: 28050835; Southwick, Charles H. 1,2; Blood, Benjamin D. 1,2; Affiliations: 1 : School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205; 2 : Interagency Primate Steering Committee, National Institutes of Health, Bethesda, MD 20014;  Source Info: Apr1979, Vol. 29 Issue 4, p233; Thesaurus Term: Zoogeography; Thesaurus Term: Wildlife conservation; Thesaurus Term: Ecosystem health; Thesaurus Term: Biotic communities; Thesaurus Term: Wildlife management; Thesaurus Term: Wildlife management areas; Thesaurus Term: Ecology; Subject Term: Primates; Subject Term: Animal population density; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 4154
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Moses, Regina M.
AU  - Steinberg, Susan
T1  - Does the MA-1 respirator make you nervous?
JO  - RN
JF  - RN
Y1  - 1979/04//
VL  - 42
IS  - 4
M3  - Article
SP  - 34
EP  - 44
SN  - 00337021
AB  - Provides information on MA-1 respirator, a positive pressure volume ventilator.  Categories of the indications for respiratory support; Conditions that affect the musculoskeletal system; Information on MA-1 works; Functions of the controls and alarms in the MA-1 respirator; Impact of mechanical ventilation on cardiovascular function.  INSETS: How mechanical ventilation affects the body: Some problems to;I saw the MA-1 through a patient's eyes--my own.
KW  - RESPIRATORS (Medical equipment)
KW  - MEDICAL equipment
KW  - RESPIRATORY therapy -- Equipment & supplies
N1  - Accession Number: 4882487; Moses, Regina M. 1; Steinberg, Susan 2; Source Information: Apr79, Vol. 42 Issue 4, p34; Subject: RESPIRATORS (Medical equipment); Subject: MEDICAL equipment; Subject: RESPIRATORY therapy -- Equipment & supplies; Number of Pages: 12p; Illustrations: 2 Black and White Photographs, 2 Diagrams; Document Type: Article; Full Text Word Count: 6232
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - GEN
AU  - Loeb, Gerald E.
T1  - LETTER.
JO  - Scientific American
JF  - Scientific American
Y1  - 1979/04//
VL  - 240
IS  - 4
M3  - Letter
SP  - 10
EP  - 10
SN  - 00368733
AB  - A letter to the editor is presented in response to the article "The Coupled Motions of Piano Strings," by Gabriel Weinreich in the January 1979 issue.
KW  - Letters to the editor
KW  - Weinreich, Gabriel
N1  - Accession Number: 20097144; Loeb, Gerald E. 1; Affiliations: 1: Laboratory of Neural Control National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health, U.S. Public Health Service, Department of Health, Education and Welfare Bethesda, Md.; Issue Info: Apr79, Vol. 240 Issue 4, p10; Subject Term: Letters to the editor; People: Weinreich, Gabriel; Number of Pages: 1/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2005-09247-001
AN  - 2005-09247-001
AU  - Shah, Saleem A.
T1  - Professionals and the Community: Some Considerations of Public Policy and Professional Parochiality.
JF  - Professional Psychology
JO  - Professional Psychology
JA  - Prof Psychol
Y1  - 1979/04//
VL  - 10
IS  - 2
SP  - 133
EP  - 134
CY  - US
PB  - American Psychological Association
SN  - 0033-0175
N1  - Accession Number: 2005-09247-001. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Shah, Saleem A.; National Institute of Mental Health, Center for Studies of Crime and Delinquency, US. Release Date: 20060327. Correction Date: 20100412. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Psychology; Social Influences; Interpersonal Control. Minor Descriptor: Professional Personnel; Professional Standards. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Apr, 1979. Copyright Statement: American Psychological Association. 1979. 
AB  - This article focuses on occupational groups that have succeeded in attaining the status of professions, as this term has been used by sociologists. The privilege and power that increasingly are exercised by major professional groups raise important questions about how these influences affect the interests and welfare of the general public. The point being emphasized here is simply that the values, ideologies, and policies espoused by professional and other special interest groups cannot be equated with, nor can they be viewed as necessarily synonymous or even consistent with, the public interest. It was asserted that clinical psychologists while pointing to the arrogance of other professions have shown a 'me-tooism' regarding the power and privilege enjoyed by colleagues in medicine and psychiatry. The author suggests that psychology learn from recent history related to issues of social accountability that have been raised in relation to other powerful professions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - public policy
KW  - professional & occupational groups
KW  - special interest groups
KW  - social influence
KW  - values
KW  - ideologies
KW  - psychology
KW  - medical profession
KW  - 1979
KW  - Psychology
KW  - Social Influences
KW  - Interpersonal Control
KW  - Professional Personnel
KW  - Professional Standards
KW  - 1979
DO  - 10.1037/h0078168
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-43131-006
AN  - 2013-43131-006
AU  - Shore, Milton F.
AU  - Massimo, Joseph L.
T1  - Fifteen years after treatment: A follow-up study of comprehensive vocationally-oriented psychotherapy.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1979/04//
VL  - 49
IS  - 2
SP  - 240
EP  - 245
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-43131-006. PMID: 434118 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Male Delinquency; Psychotherapy; Remedial Education; Vocational Rehabilitation. Minor Descriptor: Adjustment; Personnel Placement. Classification: Criminal Behavior & Juvenile Delinquency (3236); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study; Interview; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1979. Copyright Statement: American Orthopsychiatric Association, Inc. 1979. 
AB  - The fourth follow-up study of adolescent delinquent boys treated in a community-based program that combined job placement, remedial education, and psychotherapy indicates that the better overall adjustment of the treated group, compared to untreated controls, is maintained well into adulthood. It reaffirms the importance of developing sound, innovative means of reaching adolescents in crisis, and suggests the value of a full-scale replication of the original program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - vocationally oriented psychotherapy
KW  - delinquent boys
KW  - remedial education
KW  - job placement
KW  - adjustment
KW  - 1979
KW  - Male Delinquency
KW  - Psychotherapy
KW  - Remedial Education
KW  - Vocational Rehabilitation
KW  - Adjustment
KW  - Personnel Placement
KW  - 1979
DO  - 10.1111/j.1939-0025.1979.tb02605.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - POLLIN, WILLIAM
T1  - Pert and the Lasker Award.
JO  - Science
JF  - Science
Y1  - 1979/04/06/
VL  - 204
IS  - 4388
M3  - Article
SP  - 8
EP  - 8
SN  - 00368075
N1  - Accession Number: 85199595; POLLIN, WILLIAM 1; Affiliations: 1: Office, Director, Division of Research, National Institute on Drug Abuse, Rockville, Maryland 208S7; Issue Info: 4/ 6/1979, Vol. 204 Issue 4388, p8; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KOZAK, CHRISTINE A.
AU  - ROWE, WALLACE P.
T1  - Genetic Mapping of the Ecotropic Murine Leukemia Virus-Inducing Locus of BALB/c Mouse to Chromosome 5.
JO  - Science
JF  - Science
Y1  - 1979/04/06/
VL  - 204
IS  - 4388
M3  - Article
SP  - 69
EP  - 71
SN  - 00368075
AB  - By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALBIc mice, was mapped to chromosome 5, 23 units from the locusforphosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199629; KOZAK, CHRISTINE A. 1; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 6/1979, Vol. 204 Issue 4388, p69; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOONE, CHARLES W.
AU  - TAKEICHI, NORITOSHI
AU  - EATON, SOL DEL ANDE
AU  - PARANJPE, MEERA
T1  - "Spontaneous" Neoplastic Transformation in vitro: A Form of Foreign Body (Smooth Surface) Tumorigenesis.
JO  - Science
JF  - Science
Y1  - 1979/04/13/
VL  - 204
IS  - 4389
M3  - Article
SP  - 177
EP  - 179
SN  - 00368075
AB  - Explants of subcutaneous connective tissue from adult BALBIc mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate(2.4 × 104 to 3.4 × 105 cells per plate)formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did notform tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1l/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smoothsurfaced foreign bodies, regardless of theirchemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogenfirst in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85199683; BOONE, CHARLES W. 1; TAKEICHI, NORITOSHI 1; EATON, SOL DEL ANDE 1; PARANJPE, MEERA 1; Affiliations: 1: Cell Biology Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/13/1979, Vol. 204 Issue 4389, p177; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FILIPSKI, JAN
AU  - KOHN, KURT W.
AU  - PRATHER, RICHARD
AU  - BONNER, WILLIAM M.
T1  - Thiourea Reverses Cross-Links and Restores Biological Activity in DNA Treated with Dichlorodiaminoplatinum(II).
JO  - Science
JF  - Science
Y1  - 1979/04/13/
VL  - 204
IS  - 4389
M3  - Article
SP  - 181
EP  - 183
SN  - 00368075
AB  - Cis and trans dichlorodiaminoplatinum(JI) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt(IJ) treatment of λ DNA decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated λDNA can be restored. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85199685; FILIPSKI, JAN 1; KOHN, KURT W. 1; PRATHER, RICHARD 1; BONNER, WILLIAM M. 1; Affiliations: 1: Laboratory of Molećular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/13/1979, Vol. 204 Issue 4389, p181; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSTEIN, J. N.
AU  - MAGIN, R. L.
AU  - YATVIN, M. B.
AU  - ZAHARKO, D. S.
T1  - Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors.
JO  - Science
JF  - Science
Y1  - 1979/04/13/
VL  - 204
IS  - 4389
M3  - Article
SP  - 188
EP  - 191
SN  - 00368075
AB  - Liposomnes with phase transitions a few! degrees above physiological temperatuire delivered more than four times as much mnethotrexate to murine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reduc tase, the enzyme blocked by mnethotrexate in its role as an antineoplastic agent. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85199689; WEINSTEIN, J. N. 1; MAGIN, R. L. 2; YATVIN, M. B. 3; ZAHARKO, D. S. 2; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Chemical Pharmacology, Division of Cancer Treatment, National Cancer Institute; 3: Radiobiology Research Laboratory, Department of Human Oncology, University of Wisconsin, Madison 53706; Issue Info: 4/13/1979, Vol. 204 Issue 4389, p188; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Huan, Kuo-Ping
T1  - Regulation of Glycogen Synthase Activity in Choriocarcinoma Cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1979/04/17/
VL  - 95
IS  - 3
M3  - Article
SP  - 477
EP  - 485
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Choriocarcinoma cell glycogen synthase exists predominantly in the form dependent on glucose- 6-phosphate during growth. This enzyme can not be converted to the form independent of glucose 6-phosphate by endogenous phosphoprotein phosphatase, rabbit liver phosphoprotein phosphatase, or human placental alkaline phosphatase. However, the glycogen synthase present in the extract of cells which have been subjected to glucose starvation for 24 h can be converted to the form independent of glucose 6-phosphate by these phosphatases. The activity which converts the form dependent on glucose 6-phosphate to the form independent of glucose 6-phosphate by the endogenous phosphatase is progressively increased during starvation. This increase in activity is blocked by the presence of 20 μM cycloheximide in the medium. Analysis of the kinetic properties of glycogen synthase isolated from cells during starvation shows that the A0.5 value (the activator concentration giving 50 % maximal activity) for glucose 6-phosphate and the Sos value (the substrate concentration giving 50 % maximum activity) for UDP-glucose are reduced. This reduction in the kinetic constants of the enzyme is also prevented by the presence of cycloheximide. The starvation- induced change in the kinetic properties of the enzyme can be reversed by the incubation of the starved-cell extract with ATP, Mg2+, and cyclic AMP or by refeeding the starved cells with medium containing high glucose. Also, the glycogen synthase which has similar kinetic properties to the enzyme found in the starved cells can be derived from the enzyme present in normal cultures. This involves mixing a small portion of the starved cell extract with a large portion of normal cellular extract and incubating under conditions favoring dephosphorylation. It appears that during glucose starvation glycogen synthase is partially dephosphorylated, and the resulting enzyme, still in a form dependent on glucose 6-phosphate, has a lower A0.5 value for glucose 6-phosphate and a lower S0.5 value for UDP-glucose than the enzyme from cells without starvation. The starvation- induced modification of the form of the enzyme dependent on glucose 6-phosphate transforms it into a better substrate for phosphoprotein phosphatase. [ABSTRACT FROM AUTHOR]
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KW  - GLYCOGEN
KW  - CHORIOCARCINOMA
KW  - GLYCOGEN storage disease
KW  - MONOSACCHARIDES
KW  - CELLS
KW  - PHOSPHOPROTEIN phosphatases
N1  - Accession Number: 13615857; Huan, Kuo-Ping 1; Affiliation:  1: Section on Developmental Enzymology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland.; Source Info: 4/17/79, Vol. 95 Issue 3, p477; Subject Term: GLYCOGEN; Subject Term: CHORIOCARCINOMA; Subject Term: GLYCOGEN storage disease; Subject Term: MONOSACCHARIDES; Subject Term: CELLS; Subject Term: PHOSPHOPROTEIN phosphatases; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ANDERSEN, PHILIP R.
AU  - BARBACID, MARIANO
AU  - TRONICK, STEVEN R.
AU  - CLARK, H. FRED
AU  - AARONSON, STUART A.
T1  - Evolutionary Relatedness of Viper and Primate Endogenous Retroviruses.
JO  - Science
JF  - Science
Y1  - 1979/04/20/
VL  - 204
IS  - 4390
M3  - Article
SP  - 318
EP  - 321
SN  - 00368075
AB  - A retrovirus previously isolated from a tumored Russell's viper is shown by molecular hybridization to be an endogenous virus of this reptilian species. Radioimmunologic techniques revealed that the viper retrovirus is immunologically and, hence, evolutionarily related to endogenous type D retroviruses of Old World primates. These findings extend the number of vertebrate classes possessing endogenous retroviruses and suggest that type D retroviruses may even be more widely distributed in nature than type C retroviruses. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85199745; ANDERSEN, PHILIP R. 1; BARBACID, MARIANO 1; TRONICK, STEVEN R. 1; CLARK, H. FRED 2; AARONSON, STUART A. 3; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 3: Laboratory of Cellular and Molecular Biology, National Cancer Institute; Issue Info: 4/20/1979, Vol. 204 Issue 4390, p318; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HEFETZ, ABRAHAM
AU  - FALES, HENRY M.
AU  - BATRA, SUZANNE W. T.
T1  - Natural Polyesters: Dufour's Gland Macrocyclic Lactones Form Brood CeU Laminesters in CoUetes Bees.
JO  - Science
JF  - Science
Y1  - 1979/04/27/
VL  - 204
IS  - 4391
M3  - Article
SP  - 415
EP  - 417
SN  - 00368075
AB  - Bees in the genus Colletes make their brood cells in the ground and coat them with a highly resistant, waterproof, transparent membrane. This membrane is a polyester constructed maifiiY from 18-hydroxyoctadecanoic acid and 20-hydroxyeicosanoic acid, which are stored as their corresponding lactones in the Dufour's gland of the bee. When lining the cells, the bee secretes its glandular content, and the membrane is apparently a product of polycondensation reaction 'of its contents. This appears to be the first report of a naturally occurring linear polyester. The term laminester (lamina =layer + ester) for this class of compounds is proposed. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85199790; HEFETZ, ABRAHAM 1; FALES, HENRY M. 1; BATRA, SUZANNE W. T. 2; Affiliations: 1: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Beneficial Insect Introduction Laboratory, Insect Identification and Beneficial Insect Introduction Institute, Science and Education Administration, Department of Agriculture, Beltsville, Maryland 20705; Issue Info: 4/27/1979, Vol. 204 Issue 4391, p415; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Blair, Aaron
AU  - Decoufle, Pierre
AU  - Grauman, Dan
T1  - Causes of Death among Laundry and Dry Cleaning Workers.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1979/05//
VL  - 69
IS  - 5
M3  - Article
SP  - 508
EP  - 511
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the study that compared the specific causes of death in a small group of former laundry and dry cleaning workers against the experience of the general population in the U.S. During the data collection phase of the study, researchers obtained a limited set of mortality records for the period 1957-1977 from two union groups, the Laundry, Dry Cleaning and the Dye House Workers' International Union. In the study, the increased proportion of cancer deaths among laundry and dry cleaning workers suggest an elevated risk resulting from exposure to dry cleaning fluids.
KW  - OCCUPATIONAL mortality
KW  - MORTALITY -- Statistics
KW  - LAUNDRY workers
KW  - SERVICE industries workers
KW  - HAZARDOUS substances -- Health aspects
KW  - INDUSTRIAL hygiene
KW  - INDUSTRIAL safety
KW  - DRY cleaning industry
KW  - LAUNDRY industry
KW  - UNITED States
N1  - Accession Number: 6005867; Blair, Aaron 1 Decoufle, Pierre 1 Grauman, Dan 1; Affiliation:  1: Environmental Epidemiology Branch, National Lancer Institute, National Institutes of Health, Bethesda, MD 20014; Source Info: May79, Vol. 69 Issue 5, p508; Subject Term: OCCUPATIONAL mortality; Subject Term: MORTALITY -- Statistics; Subject Term: LAUNDRY workers; Subject Term: SERVICE industries workers; Subject Term: HAZARDOUS substances -- Health aspects; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: DRY cleaning industry; Subject Term: LAUNDRY industry; Subject Term: UNITED States; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 812310 Coin-Operated Laundries and Drycleaners; NAICS/Industry Codes: 812331 Linen Supply; NAICS/Industry Codes: 812332 Industrial Launderers; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Garwood, Marcia K.
AU  - Engel, Bernard T.
AU  - Quilter, Reginald E.
T1  - Age Differences in the Effect of Epidermal Hydration on Electrodermal Activity.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1979/05//
VL  - 16
IS  - 3
M3  - Article
SP  - 311
EP  - 317
SN  - 00485772
AB  - The effect of epidermal hydration on skin potential and conductance measurements was investigated in young and old men. The condition of least hydration used a 0.5% KCI glycol electrolyte. Two conditions used a 0.5% aqueous KCI electrolyte differing in that the most hydrated site received a 15-min pretreatment of soaking in distilled water whereas the intermediate hydration site received no pretreatment. These hydration conditions were used in recording three channels of skin potential and three channels of skin conductance during three tasks: 1) tone presentations after rest, 2) simple reaction time, and 3) choice reaction time. There were no significant age differences in the effect of electrolyte on skin conductance level and response. There were age differences in the effect of electrolyte on skin potential level (SPL) and response (SPR). Young adult SPR was monotonically related to hydration with the largest response magnitude occurring with the least hydration. Electrolyte did not significantly affect SPR magnitude of the aged. For the young subjects, SPL was monotonically related to hydration with the most negative SPL occurring with the least hydration. For the aged subjects, the least negative SPL occurred in the condition of least hydration. We postulate that this reversal in the hydration/SPL relationship in old age reflects a reversal in the relative magnitudes of sweat gland and epidermal potentials: in old subjects the epidermal potential is greater than the sweat gland potential. [ABSTRACT FROM AUTHOR]
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KW  - GALVANIC skin response
KW  - HYDRATION
KW  - AGING
KW  - REACTION time
KW  - ELECTROLYTES
KW  - SWEAT glands
KW  - Aging
KW  - Hydration
KW  - Skin conductance
KW  - Skin potential.
N1  - Accession Number: 11195382; Garwood, Marcia K. 1 Engel, Bernard T. 2 Quilter, Reginald E. 3; Affiliation:  1: Gerontology Research Center (Baltimore) National Institute on Aging National Institutes of Health PHS.  2: U.S. Department of Health Education and Welfare Bethesda.  3: Baltimore City Hospitals Baltimore.; Source Info: May1979, Vol. 16 Issue 3, p311; Subject Term: GALVANIC skin response; Subject Term: HYDRATION; Subject Term: AGING; Subject Term: REACTION time; Subject Term: ELECTROLYTES; Subject Term: SWEAT glands; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Hydration; Author-Supplied Keyword: Skin conductance; Author-Supplied Keyword: Skin potential.; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1469-8986.ep11195382
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Borgatta, Edgar F.
AU  - Jackson, David J.
T1  - AGGREGATE DATA ANALYSIS.
JO  - Sociological Methods & Research
JF  - Sociological Methods & Research
Y1  - 1979/05//
VL  - 7
IS  - 4
M3  - Article
SP  - 379
SN  - 00491241
AB  - This article discusses various issues related to aggregate data analysis, with particular emphasis on the nature of measurement for aggregated data. With the wisdom of hindsight, more recent generations have been able to look back and see the methodological errors of the past in interpretation of aggregated data, and at this juncture, the questions surrounding the use of aggregated data are becoming systematized. The issues that are raised in dealing with aggregated data proceed on to many questions that involve assumptions about the concepts that are used, metric, and so forth. Aside from the complexity of process that is implied in some of the arbitrary procedures of aggregating data, sometimes the concept that is involved is not represented well by the operations involved in the creation of the measure. For example, the idea of city size may suggest many alternative measures, but for most it will conjure up an image of the metropolis as compared to a small town or city. City size is usually thought of in terms of the population size, the number of people within the geographical boundary. Population size is only one indication of size, and intrinsically one may be suggesting the concentration, density, with the concept rather than the total count.
KW  - SOCIOLOGY -- Methodology
KW  - DATA analysis
KW  - QUANTITATIVE research
KW  - STATISTICAL reliability
KW  - INFORMATION retrieval
KW  - SOCIOLOGICAL research
N1  - Accession Number: 5863258; Borgatta, Edgar F. 1; Jackson, David J. 2; Source Information: May79, Vol. 7 Issue 4, p379; Subject: SOCIOLOGY -- Methodology; Subject: DATA analysis; Subject: QUANTITATIVE research; Subject: STATISTICAL reliability; Subject: INFORMATION retrieval; Subject: SOCIOLOGICAL research; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2006-06574-037
AN  - 2006-06574-037
AU  - Yarrow, Leon J.
T1  - Counsel for Counselors.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1979/05//
VL  - 24
IS  - 5
SP  - 399
EP  - 401
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06574-037. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development (NIH), US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Counselors; Parental Role; Parents. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Arnold, L. Eugene (Ed). Helping Parents Help Their Children=New York: Brunner/Mazel, 1978. Pp. xv + 420. $17.50; 1978. Page Count: 3. Issue Publication Date: May, 1979. 
AB  - Reviews the book, Helping Parents Help Their Children edited by L. Eugene Arnold (1978). The objectives of this book are succinctly stated in the title; it is addressed to counselors of parents. In an excellent opening chapter, general principles of parental guidance are presented by the editor. The second section of this volume consists of a series of short chapters, each on a conceptual approach to parental guidance. The third section considers parents and children with specific problems: mentally and physically handicapped children, delinquent children, hyperactive children, and autistic and neurotic children. On the whole, each presentation is tight, most are clearly written, and many are insight provoking. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - parental guidance
KW  - counselors
KW  - parents
KW  - Childhood development
KW  - 1979
KW  - Childhood Development
KW  - Counselors
KW  - Parental Role
KW  - Parents
KW  - 1979
U2  - Arnold, L. Eugene (Ed). (1978); Helping Parents Help Their Children; New York: Brunner/Mazel, 1978. Pp. xv + 420. $17.50
DO  - 10.1037/019015
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - LOVENBERG, W.
AU  - LEVINE, R. A.
AU  - ROBINSON, D. S.
AU  - EBERT, M.
AU  - WILLIAMS, A. C.
AU  - CALNE, D. B.
T1  - Hydroxylase Cofactor Activity in Cerebrospinal Fluid of Normal Subjects and Patients with Parkinson's Disease.
JO  - Science
JF  - Science
Y1  - 1979/05/11/
VL  - 204
IS  - 4393
M3  - Article
SP  - 624
EP  - 626
SN  - 00368075
AB  - A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrospinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268844; LOVENBERG, W. 1; LEVINE, R. A. 1; ROBINSON, D. S. 1; EBERT, M. 2; WILLIAMS, A. C. 3; CALNE, D. B. 3; Affiliations: 1: Section on Biochemical Pharmacology, Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 3: Experimental Therapeutics Branch, IRP, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; Issue Info: 5/11/1979, Vol. 204 Issue 4393, p624; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PERLOW, MARK J.
AU  - FREED, WILLIAM J.
AU  - HOFFER, BARRY J.
AU  - SEIGER, AKE
AU  - OLSON, LARS
AU  - WYATT, RICHARD JED
T1  - Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System.
JO  - Science
JF  - Science
Y1  - 1979/05/11/
VL  - 204
IS  - 4393
M3  - Article
SP  - 643
EP  - 647
SN  - 00368075
AB  - In order to determine if brain tissue grafts can provide functional input to recipient central nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities, which had been induced by the destruction of the endogenous dopaminergic input to the caudate, were significantly reduced after grafting of the fetal brain tissue. These data suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268853; PERLOW, MARK J. 1; FREED, WILLIAM J. 1; HOFFER, BARRY J. 2; SEIGER, AKE 3; OLSON, LARS 3; WYATT, RICHARD JED 4; Affiliations: 1: Unit on Geriatric Psychiatry, Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pharmacology, University of Colorado School of Medicine, Denver 80262; 3: Department of Histology, Karolinska Institute, Stockholm, Sweden; 4: Unit on Geriatric Psychiatry, Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital; Issue Info: 5/11/1979, Vol. 204 Issue 4393, p643; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GART, JOHN J.
AU  - SCHNEIDERMAN, MARVIN A.
AU  - GORI, GIO B.
T1  - "Low-Risk" Cigarettes: The Debate Continues.
JO  - Science
JF  - Science
Y1  - 1979/05/18/
VL  - 204
IS  - 4394
M3  - Article
SP  - 688
EP  - 692
SN  - 00368075
N1  - Accession Number: 85195484; GART, JOHN J.; SCHNEIDERMAN, MARVIN A.; GORI, GIO B. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/18/1979, Vol. 204 Issue 4394, p688; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Zahn-Waxler, Carolyn
AU  - Radke-Yarrow, Marian
AU  - King, Robert A.
T1  - Child Rearing and Children's Prosocial Initiations toward Victims of Distress.
JO  - Child Development
JF  - Child Development
Y1  - 1979/06//
VL  - 50
IS  - 2
M3  - Article
SP  - 319
EP  - 330
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12421504; Zahn-Waxler, Carolyn 1 Radke-Yarrow, Marian 1 King, Robert A. 2; Affiliation:  1: National Institute of Mental Health  2: Children's Hospital, Washington, D.C.; Source Info: Jun1979, Vol. 50 Issue 2, p319; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1467-8624.ep12421504
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gladen, Beth
T1  - The Use of the Jackknife to Estimate Proportions From Toxicological Data in the Presence of Litter Effects.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1979/06//Jun79 Part 1
VL  - 74
IS  - 366
M3  - Article
SP  - 278
SN  - 01621459
AB  - The jackknifing methodology is proposed as a way of estimating and comparing proportions of affected fetuses in animal experiments. The estimate is a weighted average of the proportions in individual litters and is almost fully efficient in several cases of interest. The associated standard error is asymptotically correct for a wide range of possible models. Jackknife-based tests are shown to be competitive with other methods currently used. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESTIMATION theory
KW  - STATISTICS
KW  - JACKKNIFE (Statistics)
KW  - RESAMPLING (Statistics)
KW  - TERATOLOGY
KW  - SCIENTIFIC experimentation
KW  - ABNORMALITIES in animals
KW  - Beta-binomial
KW  - Chi-squared tests
KW  - Teratology.
N1  - Accession Number: 4609103; Gladen, Beth 1; Affiliations: 1: Staff Fellow, Biometry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Jun79 Part 1, Vol. 74 Issue 366, p278; Thesaurus Term: ESTIMATION theory; Thesaurus Term: STATISTICS; Subject Term: JACKKNIFE (Statistics); Subject Term: RESAMPLING (Statistics); Subject Term: TERATOLOGY; Subject Term: SCIENTIFIC experimentation; Subject Term: ABNORMALITIES in animals; Author-Supplied Keyword: Beta-binomial; Author-Supplied Keyword: Chi-squared tests; Author-Supplied Keyword: Teratology.; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2004-20774-006
AN  - 2004-20774-006
AU  - Trela, James E.
AU  - Jackson, David J.
T1  - Family Life and Community Participation in Old Age.
JF  - Research on Aging
JO  - Research on Aging
JA  - Res Aging
Y1  - 1979/06//
VL  - 1
IS  - 2
SP  - 233
EP  - 251
CY  - US
PB  - Sage Publications
SN  - 0164-0275
SN  - 1552-7573
N1  - Accession Number: 2004-20774-006. Partial author list: First Author & Affiliation: Trela, James E.; Department of Sociology, University of Maryland Baltimore County, Catonsville, MD, US. Release Date: 20041227. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Scientific Meeting of the Gerontonlogical Society, 29th, Oct, 1976, New York, NY, US. Conference Note: This article was presented at the aforementioned conference. Major Descriptor: Aging; Community Involvement; Family Relations; Participation; Roles. Minor Descriptor: Communities. Classification: Gerontology (2860). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Jun, 1979. 
AB  - This article examines the relationship between the availability of family roles and several dimensions of participation in community life in order to determine the interrelatedness and substitutability of these two spheres of role-playing opportunities. The data for this analysis derive from a panel study of 320 aged individuals. The data suggest that, in some cases, community roles may be conceived as functional substitutes for family roles, with the role of spouse being the pivotal link to understanding the relative value of these roles. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - family roles
KW  - community participation
KW  - involvement
KW  - family life
KW  - community roles
KW  - old age
KW  - 1979
KW  - Aging
KW  - Community Involvement
KW  - Family Relations
KW  - Participation
KW  - Roles
KW  - Communities
KW  - 1979
DO  - 10.1177/016402757912006
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-08422-012
AN  - 2011-08422-012
AU  - Brownstein, Michael J.
T1  - Review of Perspectives in endocrine psychobiology.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/06//
VL  - 167
IS  - 6
SP  - 377
EP  - 377
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
N1  - Accession Number: 2011-08422-012. Partial author list: First Author & Affiliation: Brownstein, Michael J.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Disorders; Endocrine System; Pathophysiology; Psychobiology. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Reviewed Item: Brambilla, F. (Ed); Bridges, P. K. (Ed); Endroczi, E. (Ed); Heuser, G. (Ed). Perspectives in endocrine psychobiology=John Wiley & Sons, New York, 590 pp., $39.95; 1978. Page Count: 1. Issue Publication Date: Jun, 1979. Copyright Statement: The Williams & Wilkins Co. 1979. 
AB  - Reviews the book, Perspectives in endocrine psychobiology edited by F. Brambilla, P. K. Bridges, E. Endroczi, and G. Heuser (1978). This book is not a well integrated textbook dealing with hormones and behavior, nor is it a reference volume. It is instead 13 isolated chapters concerning such disparate topics as steroid hormone binding, control of anterior pituitary function, neurotransmitters and psychosis, psychological and endocrinological changes in puberty, the biological basis of personality, and the pathophysiology and treatment of pituitary tumors. Some of these chapters are well organized reviews of specific areas of basic or clinical science. Unfortunately, the book also contains a number of uncritical reviews of the literature with sensationally long bibliographies. A final chapter providing a cybernetic view of brain activities is so full of jargon that it is nearly incomprehensible. For the most part, what has been said in this book has been said as well or better elsewhere. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - endocrine system
KW  - psychobiology
KW  - physiology
KW  - disorders
KW  - 1979
KW  - Disorders
KW  - Endocrine System
KW  - Pathophysiology
KW  - Psychobiology
KW  - 1979
U2  - Brambilla, F. (Ed); Bridges, P. K. (Ed); Endroczi, E. (Ed); Heuser, G. (Ed). (1978); Perspectives in endocrine psychobiology; John Wiley & Sons, New York, 590 pp., $39.95
DO  - 10.1097/00005053-197906000-00012
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-08422-021
AN  - 2011-08422-021
AU  - Ochberg, Frank M.
T1  - Review of Violence and responsibility and Brain dysfunction in aggressive criminals.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/06//
VL  - 167
IS  - 6
SP  - 381
EP  - 382
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
N1  - Accession Number: 2011-08422-021. Partial author list: First Author & Affiliation: Ochberg, Frank M.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Aggressive Behavior; Brain Disorders; Criminal Behavior; Responsibility; Violence. Minor Descriptor: Criminals; Electroencephalography. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Reviewed Item: Sadoff, Robert L. (Ed). Violence and responsibility=John Wiley & Sons, Somerset, N.J., 139 pp., $14.95; 1978. Monroe, Russell R. Brain dysfunction in aggressive criminals=D. C. Heath and Co., Lexington, Mass., xiii + 223 pp., $17.95; 1978. Page Count: 2. Issue Publication Date: Jun, 1979. Copyright Statement: The Williams & Wilkins Co. 1979. 
AB  - Reviews the books, Violence and responsibility edited by Robert L. Sadoff (see record [rid]1980-00828-000[/rid]) and Brain dysfunction in aggressive criminals by Russell R. Monroe (1978). Violence and responsibility is a symposium synopsis. Such books are often tedious and disjointed, but this one is short enough to be read at a sitting, and clear enough to be appreciated by the nonspecialist. In fact, the book should appeal to a general medical audience as well as mental health professionals and criminologists. If this volume describes the scope of issues in human violence, Brain dysfunction in aggressive criminals plumbs the depths. Monroe and colleagues at the University of Maryland recently examined intensively and objectively a population of institutionalized recidivists. The conclusions are modest, but of significance: 93 subjects could be assigned to four groups according to EEG abnormality (θ elevation) and behavioral discontrol (self-rating). Monroe et al. explained their assumptions and research strategies well, summarizing related literature as they proceed. Results are presented with less clarity than one might like. The authors promise hypothesis testing rather than hypothesis generation—but this reader is left with more questions than answers. No matter: the authors prove that certain patterns of violent behavior are best comprehended in biological terms, of heuristic and practical significance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - violence
KW  - responsibility
KW  - brain dysfunction
KW  - aggressive behavior
KW  - criminals
KW  - electroencephalography
KW  - EEGs
KW  - 1979
KW  - Aggressive Behavior
KW  - Brain Disorders
KW  - Criminal Behavior
KW  - Responsibility
KW  - Violence
KW  - Criminals
KW  - Electroencephalography
KW  - 1979
U2  - Sadoff, Robert L. (Ed). (1978); Violence and responsibility; John Wiley & Sons, Somerset, N.J., 139 pp., $14.95
U2  - Monroe, Russell R. (1978); Brain dysfunction in aggressive criminals; D. C. Heath and Co., Lexington, Mass., xiii + 223 pp., $17.95
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - STRITTMATTER, WARREN J.
AU  - HIRATA, FUSAO
AU  - AXELROD, JULIUS
T1  - Phospholipid Methylation Unmasks Cryptic, β-Adrenergic Receptors in Rat Reticulocytes.
JO  - Science
JF  - Science
Y1  - 1979/06/15/
VL  - 204
IS  - 4398
M3  - Article
SP  - 1205
EP  - 1207
SN  - 00368075
AB  - The effect of phospholipid methylation on the number of fadrenergic receptor binding sites was examined in rat reticulocyte membranes. Stimulation of phosphatidylcholine synthesis by the introduction of the methyl donor S-adenosyl-Lmethionine into reticulocyte ghosts increased the number of β-adrenergic receptor binding sites. The appearance of β-adrenergic binding sites was dependent on the formation of phosphatidylcholine by the enzyme that converts phosphatidyl-Nmonomethylethanolamine to phosphatidylcholine, but not on the synthesis of phosphatidyl- N-monomethylethanolamine from phosphatidylethanolamine. Both the synthesis of phosphatidylcholine and the unmasking of cryptic receptors were time and temperature dependent and did not occur in the presence of the methyl transferase inhibitor, S-adenosyl-L-homocysteine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85195701; STRITTMATTER, WARREN J. 1; HIRATA, FUSAO 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/15/1979, Vol. 204 Issue 4398, p1205; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CANTACUZENE, DANIELE
AU  - KIRK, KENNETH L.
AU  - MCCULLOH, DAVID H.
AU  - CREVELING, CYRUS R.
T1  - Effect of Fluorine Substitution on the Agonist Specificity of Norepinephrine.
JO  - Science
JF  - Science
Y1  - 1979/06/15/
VL  - 204
IS  - 4398
M3  - Article
SP  - 1217
EP  - 1219
SN  - 00368075
AB  - offluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the α - and β-adrenergic agonist properties of norepinephrine. The 6-fluoro isomer is an α -adrenergic agonist with virtually no β agonist activity, while the 2-fluoro isomer is a β-adrenergic agonist with little a activity. The 5-fluoro isomer is equipotent with norepinephrine as an a agonist and significantly more potent as a β agonist. The possible physiochemical basis for these differences is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85195706; CANTACUZENE, DANIELE 1,2; KIRK, KENNETH L. 1,2; MCCULLOH, DAVID H. 3; CREVELING, CYRUS R. 3; Affiliations: 1: Laboratory of Chemistry, National Institute of Arthritis, Metabolism; 2: Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 3: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases; Issue Info: 6/15/1979, Vol. 204 Issue 4398, p1217; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KNAPKA, JOSEPH J.
T1  - Laboratory Animal Feed.
JO  - Science
JF  - Science
Y1  - 1979/06/29/
VL  - 204
IS  - 4400
M3  - Article
SP  - 1367
EP  - 1367
SN  - 00368075
N1  - Accession Number: 85195763; KNAPKA, JOSEPH J. 1; Affiliations: 1: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 6/29/1979, Vol. 204 Issue 4400, p1367; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Miller, Joanne
AU  - Schooler, Carmi
AU  - Kohn, Melvin L.
AU  - Miller, Karen A.
T1  - Women and Work: The Psychological Effects of Occupational Conditions.
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1979/07//
VL  - 85
IS  - 1
M3  - Article
SP  - 66
EP  - 94
SN  - 00029602
AB  - Examines the effects of working conditions on the psychological functioning of working women, based on 1964 and 1974 studies.
KW  - WOMEN -- Employment
KW  - PSYCHOLOGY
KW  - WORK environment
KW  - WOMEN employees
KW  - INTERPERSONAL relations
KW  - WOMEN
KW  - SELF-perception
KW  - BEHAVIOR
KW  - ATTITUDE (Psychology)
KW  - Administrative Processes and Organizational Variables
KW  - LABOR MARKET, LABOR FORCE PARTICIPATION, AND LABOR FORCE CHARACTERISTICS
N1  - Accession Number: 15579666; Miller, Joanne 1; Schooler, Carmi 1; Kohn, Melvin L. 1; Miller, Karen A. 1; Affiliations: 1 : National Institute of Mental Health;  Source Info: Jul79, Vol. 85 Issue 1, p66; Historical Period: 1964 to 1979; Subject Term: WOMEN -- Employment; Subject Term: PSYCHOLOGY; Subject Term: WORK environment; Subject Term: WOMEN employees; Subject Term: INTERPERSONAL relations; Subject Term: WOMEN; Subject Term: SELF-perception; Subject Term: BEHAVIOR; Subject Term: ATTITUDE (Psychology); Author-Supplied Keyword: Administrative Processes and Organizational Variables; Author-Supplied Keyword: LABOR MARKET, LABOR FORCE PARTICIPATION, AND LABOR FORCE CHARACTERISTICS; Number of Pages: 29p; Illustrations: 4 Diagrams, 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - GEN
AU  - Gordon, Jerry
AU  - Hawke, Scott D.
T1  - ANIMAL EXPERIMENTATION.
JO  - BioScience
JF  - BioScience
Y1  - 1979/07//
VL  - 29
IS  - 7
M3  - Letter
SP  - 397
EP  - 397
SN  - 00063568
AB  - Two letters to the editor are presented in response to the article "Animal Experimentation: The Battle Lines Soften," in the March 1979 issue.
KW  - Animal experimentation
KW  - Vertebrates
KW  - Letters to the editor
KW  - Laboratory animals
KW  - Bioethics
N1  - Accession Number: 28049390; Gordon, Jerry 1; Hawke, Scott D. 2; Affiliations: 1 : Division of Research Resources, National Institutes of Health, Bethesda, MD 20014; 2 : Department of Biology Willamette University, Salem, OR 97301;  Source Info: Jul1979, Vol. 29 Issue 7, p397; Thesaurus Term: Animal experimentation; Thesaurus Term: Vertebrates; Subject Term: Letters to the editor; Subject Term: Laboratory animals; Subject Term: Bioethics; Number of Pages: 1/4p; Document Type: Letter; Full Text Word Count: 317
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Levis, W. R.
AU  - Dattner, A. M.
AU  - Shaw, J. S.
T1  - Selective defects in T cell function in ataxia-telangiectasia.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1979/07//
VL  - 37
IS  - 1
M3  - Article
SP  - 44
EP  - 49
PB  - Wiley-Blackwell
SN  - 00099104
AB  - We have studied three patients with ataxia-telangiectasia (AT) and found two of them to have a normal mixed leucocyte culture stimulating and responding ability. However, all three patients and one parent had defective cell-mediated lympholysis (CML), even in the face of a potent proliferative response to allogeneic leucocytes. None of these patients showed significant proliferative responses to common microbial antigens (tetanus toxoid, Candida albicans, purified protein derivative (PPD), diphtheria toxoid, influenza). Our studies indicate that the T cell defect in AT preferentially affects certain T cell functions associated with antigen recognition and the generation of allogeneic CML, while sparing the altogeneic proliferative response. The selective deficiency of specific lymphocyte functions in a thymic immunodeficiency with a known defect in DNA repair is consistent with the concept that DNA modulating enzymes are important for T cell function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - LYMPHOCYTES
KW  - ATAXIA telangiectasia
KW  - CEREBELLUM -- Diseases
KW  - CANDIDIASIS
KW  - CANDIDA albicans
KW  - CLOSTRIDIUM diseases
KW  - ANAEROBIC infections
N1  - Accession Number: 16099791; Levis, W. R. 1 Dattner, A. M. 1 Shaw, J. S. 1; Affiliation:  1: Dermatology and Immunology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.; Source Info: Jul1979, Vol. 37 Issue 1, p44; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: ATAXIA telangiectasia; Subject Term: CEREBELLUM -- Diseases; Subject Term: CANDIDIASIS; Subject Term: CANDIDA albicans; Subject Term: CLOSTRIDIUM diseases; Subject Term: ANAEROBIC infections; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wardlaw, A. C.
AU  - Parton, R.
AU  - Bergman, R. K.
AU  - Munoz, J. J.
T1  - Loss of adjuvanticity in rats for the hyperacute form of allergic encephalomyelitis and for reaginic antibody production in mice of a phenotypic variant of <em> Bordetella pertussis </em>.
JO  - Immunology
JF  - Immunology
Y1  - 1979/07//
VL  - 37
IS  - 3
M3  - Article
SP  - 539
EP  - 545
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The adjuvanticity of a phenotypic (C-mode) variant of B. pertussis, known to be deficient in certain immunological and physiopathological properties, was compared to that of the normal (X-mode) strain. The X-mode vaccine was a potent adjuvant for induction of hyperacute experimental allergic encephalomyelitis to guinea-pig spinal cord in Lewis rats whereas C-mode vaccine was inactive. X-mode vaccine was also highly active in the induction of reaginic (both IgE and IgG1) antibodies to ovalbumin in mice while C-mode vaccine caused only a transitory increase in the IgE level. These data support the view that an adjuvant component of B. pertussis, which is probably identical with the histamine-sensitizing and leukocytosis promoting factor, is much diminished in C-mode cells while the lipopolysaccharide adjuvant remains unchanged. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOLOGICAL adjuvants
KW  - BIOLOGICAL response modifiers
KW  - PREVENTIVE medicine
KW  - IMMUNOGLOBULINS
KW  - BORDETELLA pertussis
KW  - ALLERGIC encephalomyelitis
KW  - AUTOIMMUNE diseases
N1  - Accession Number: 13988628; Wardlaw, A. C. 1 Parton, R. 1 Bergman, R. K. 2 Munoz, J. J. 1; Affiliation:  1: Microbiology Department, Glasgow University, Glasgow  2: United States Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Jul79, Vol. 37 Issue 3, p539; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: BIOLOGICAL response modifiers; Subject Term: PREVENTIVE medicine; Subject Term: IMMUNOGLOBULINS; Subject Term: BORDETELLA pertussis; Subject Term: ALLERGIC encephalomyelitis; Subject Term: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Robbins, Jay H.
AU  - Moshell, Alan
T1  - DNA Repair Processes Protect Human Beings from Premature Solar Skin Damage: Evidence from Studies on Xeroderma Pigmentosum.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1979/07//
VL  - 73
IS  - 1
M3  - Article
SP  - 102
EP  - 107
SN  - 0022202X
AB  - The repair of DNA damage by ultraviolet light is defective in the hereditary disease xeroderma pigmentosum. A deoxyribonucleotide excision-proficient form and several excision-deficient forms of xeroderma pigmentosum have been identified. Premature solar skin damage develops in all xeroderma pigmentosum patients. Some patients also have neurological abnormalities caused by premature death of nerve cells. This abnormal aging of the central nervous system and of sun-exposed skin appears to be the result of the abnormal DNA repair processes. Clinical, biological, and physicochemical studies on DNA-repair-dependent processes and on the DNA repair defects in xeroderma pigmentosum are elucidating the mechanisms by which such abnormal aging is prevented in normal human beings. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN abnormalities
KW  - GENES
KW  - AGING
KW  - ULTRAVIOLET radiation
KW  - GENETIC disorders
KW  - NEUROSCIENCES
N1  - Accession Number: 12532789; Robbins, Jay H. 1 Moshell, Alan 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul79, Vol. 73 Issue 1, p102; Subject Term: SKIN abnormalities; Subject Term: GENES; Subject Term: AGING; Subject Term: ULTRAVIOLET radiation; Subject Term: GENETIC disorders; Subject Term: NEUROSCIENCES; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12532789
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ANLYAN, WILLIAM G.
AU  - GILLIN, CHRISTIAN
AU  - SOLOMON, FREDRIC
AU  - MEDD, BRUCE H.
AU  - KRIPKE, DANIEL F.
AU  - JOSEPH, HERBERT L.
T1  - Sleeping Pills and Insomnia.
JO  - Science
JF  - Science
Y1  - 1979/07/06/
VL  - 205
IS  - 4401
M3  - Article
SP  - 6
EP  - 122
SN  - 00368075
N1  - Accession Number: 85268856; ANLYAN, WILLIAM G. 1; GILLIN, CHRISTIAN 2; SOLOMON, FREDRIC 3; MEDD, BRUCE H. 4; KRIPKE, DANIEL F. 5,6; JOSEPH, HERBERT L.; Affiliations: 1: Duke University Medical Center Durham, North Carolina 27710; 2: National Institute of Mental Health Bethesda, Maryland 20857; 3: Institute of Medicine, National Academy of Sciences, Washington, D.C. 20418; 4: Professional Services, Roche Laboratories, Nutley, New Jersey 07110; 5: Department of Psychiatry, University of California, San Diego, La Jolla 92093; 6: Veterans Administration Medical Center, San Diego 92161; Issue Info: 7/ 6/1979, Vol. 205 Issue 4401, p6; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - YORKE, JAMES A.
AU  - SMALE, STEPHEN
T1  - Continuation Methods.
JO  - Science
JF  - Science
Y1  - 1979/07/06/
VL  - 205
IS  - 4401
M3  - Article
SP  - 122
EP  - 122
SN  - 00368075
N1  - Accession Number: 85268858; YORKE, JAMES A. 1,2; SMALE, STEPHEN 3; Affiliations: 1: University of Maryland, College Park 20742; 2: Laboratory of Theoretical Biology, National Cancer Institute, Bethesda, Maryland 20205; 3: Department of Mathematics, University of California, Berkeley 94720; Issue Info: 7/ 6/1979, Vol. 205 Issue 4401, p122; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SHIMIZU, YOHKO K.
AU  - FEINSTONE, STEPHEN M.
AU  - PURCELL, ROBERT H.
AU  - ALTER, HARVEY J.
AU  - LONDON, WILLIAM T.
T1  - Non-A, Non-B Hepatitis: Ultrastructural Evidence for Two Agents in Experimentally Infected Chimpanzees.
JO  - Science
JF  - Science
Y1  - 1979/07/13/
VL  - 205
IS  - 4402
M3  - Article
SP  - 197
EP  - 200
SN  - 00368075
AB  - Two different ultrastructural alterations were observed in liver cells of chimpanzees inoculated with plasma derived from two different patients with non-A, non-B hepatitis. DurinK the acute phase of illness in one group of four chimpanzees, peculiar tubular structures, composed of two unit membranes with electron-opaque material in between, were observed in the cytoplasm of hepatocytes. In contrast, these structures were never detected in the liver cells of the second group of five chimpanzees that received the second inoculum. However, nuclear changes, usually associated with aggregates of 20- to 27-nanometer particles, were found in hepatocytes of the latter animals. Although these particles resembled viruses, they were not as uniform as small virus particles often appear. In five other chimpanzees inoculated with non-A, non-B hepatitis material not known to be related to the first two inocula, cytoplasmic structures were found in four, and nuclear structures were found in the remaining one. Thus, all 14 chimpanzees inoculated with transmissible non-A, non-B hepatitis agents could be classified as having either nuclear or cytoplasmic changes. These observations add support to epidemiologic data suggesting that there may be more than one agent of non-A, non-B hepatitis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85268936; SHIMIZU, YOHKO K. 1; FEINSTONE, STEPHEN M. 1; PURCELL, ROBERT H. 1; ALTER, HARVEY J. 2; LONDON, WILLIAM T. 3; Affiliations: 1: Laboratoy of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institiutes of Health, Bethestla, Maryland 20014; 2: Clinical Center Blood Bank, National Institutes of Health; 3: National Institute of Neurological and Commnunicative Disorders and Strioke, National Institutes of Health; Issue Info: 7/13/1979, Vol. 205 Issue 4402, p197; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Chapman, Michael
AU  - Hausfater, Glenn
T1  - The Reproductive Consequences of Infanticide in Langurs: A Mathematical Model.
JO  - Behavioral Ecology & Sociobiology
JF  - Behavioral Ecology & Sociobiology
Y1  - 1979/08//
VL  - 5
IS  - 3
M3  - Article
SP  - 227
EP  - 240
SN  - 03405443
AB  - 1. An analysis of the factors influencing the reproductive success of infanticidal and noninfanticidal adult males in populations of langur monkeys (Genus Presbytis) is presented. Male tenure, defined as an adult male's length of residency in a one-male bisexual group, is demonstrated to be an important factor in any reproductive advantage accruing to infanticidal males. Other factors include the lengths of the female interconception intervals, the time at which adult male replacement occurs relative to the start of any such interval, and whether or not the subsequent replacement male is also infanticidal. 2. Infanticide is found always to confer a reproductive advantage on the resident male in a bisexual group under conditions of subsequent replacement by a noninfanticidal male. Infanticide would thus be expected to spread when introduced into an otherwise noninfanticidal population. Under conditions of subsequent replacement by an infanticidal male, infanticide is found to be advantageous for the resident male only a particular lengths of tenure. Infanticide would thus become fixed only in populations where the distribution of tenure lengths is advantageous for infanticidal males. Accordingly, it is predicted that average or modal tenure length in populations fixed for infanticide should coincide with those tenure lengths theoretically yielding a reproductive advantage for infanticidal males. Three direct estimates of average male tenure obtained from field studies of langur populations are consistent with the predictions of the model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Behavioral Ecology & Sociobiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Reproduction
KW  - Langurs
KW  - Animals -- Population biology
KW  - Presbytis
KW  - Infanticide in animals
N1  - Accession Number: 57091779; Chapman, Michael 1; Hausfater, Glenn 2; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205, USA; 2: Cornell University, Ithaca, New York 14853, USA; Issue Info: 1979, Vol. 5 Issue 3, p227; Thesaurus Term: Reproduction; Thesaurus Term: Langurs; Thesaurus Term: Animals -- Population biology; Thesaurus Term: Presbytis; Subject Term: Infanticide in animals; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lawley, T. J.
AU  - Ottesen, E. A.
AU  - Hiatt, R. A.
AU  - Gazze, L. A.
T1  - Circulating immune complexes in acute schistosomiasis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1979/08//
VL  - 37
IS  - 2
M3  - Article
SP  - 221
EP  - 227
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The sera of patients with acute and chronic schistosomiasis were tested for the presence of circulating immune complexes with the 125I-Clq binding assay. Fourteen out of fifteen (93%) patients with acute schistosomiasis had elevated 125I-Clq binding activity, while only two out of eleven (18%) patients with chronic disease had Clq binding complexes. This difference was significant (P≥ 0.001) and paralleled the degree of clinical disease activity between the two groups of patients. IgG and IgM were readily detected in all of these circulating complexes but the specific parasite antigens initiating their formation could not be defined. The level of circulating immune complexes was inversely correlated with the absolute eosinophil counts for individuals in the acutely infected group, an observation compatible with the hypothesis that a functional role for the eosinophil is the destruction and elimination of immune complexes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE complexes
KW  - SCHISTOSOMIASIS
KW  - CHRONIC diseases
KW  - IMMUNOGLOBULINS
KW  - EOSINOPHILS
KW  - SERUM
N1  - Accession Number: 16434606; Lawley, T. J. 1 Ottesen, E. A. 2 Hiatt, R. A. 3 Gazze, L. A. 4; Affiliation:  1: The Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.  2: Laboratory of Parasitic Diseases, National Institute of Allergy, National Institutes of Health, Bethesda, Maryland, USA.  3: Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.  4: San Juan Laboratories, Center for Disease Control, San Juan, Puerto Rico.; Source Info: Aug1979, Vol. 37 Issue 2, p221; Subject Term: IMMUNE complexes; Subject Term: SCHISTOSOMIASIS; Subject Term: CHRONIC diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: EOSINOPHILS; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - López-Barea, Juan
AU  - Chi-Yu Lee
T1  - Mouse-Liver Glutathione Reductase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1979/08//8/1/79
VL  - 98
IS  - 2
M3  - Article
SP  - 487
EP  - 499
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Glutathione reductase from the liver of DBA/2J mice was purified to homogeneity by means of ammonium sulfate fractionation and two subsequent affinity chromatography steps using 8-(6-aminohexyl)-amino-2′-phospho-adenosine diphosphoribose and N6-(6-aminohexyl)-adenosine 2′,5′-bisphosphate-Sepharose columns. A facile procedure for the synthesis of 8-(6-aminohexyl)-amino-2′-phospho-adenosine diphosphoribose is also presented. The purified enzyme exhibits a specific activity of 158 U/mg and an A280/A460 of 6.8. It was shown to be a dimer of Mr 105000 with a Stokes radius of 4.18 nm and an isoelectric point of 6.46. Amino acid composition revealed some similarity between the mouse and the human enzyme. Antibodies against mouse glutathione reductase were raised in rabbits and exhibited high specificity. The catalytic properties of mouse liver glutathione reductase have been studied under a variety of experimental conditions. As with the same enzyme from other sources, the kinetic data are consistent with a ‘branched’ mechanism. The enzyme was stabilized against thermal inactivation at 80 °C by GSSG and less markedly by NADP+and GSH, but not by NADPH or FAD. Incubation of mouse glutathione reductase in the presence of NADPH or NADH, but not NADP+ or NAD+, produced an almost complete inactivation. The inactivation by NADPH was time, pH and concentration dependent. Oxidized glutathione protected the enzyme against inactivation, which could also be reversed by GSSG or other electron acceptors. The enzyme remained in the inactive state even after eliminating the excess NADPH. The inactive enzyme showed the same molecular weight as the active glutathione reductase. The spectral properties of the inactive enzyme have also been studied. It is proposed that auto-inactivation of glutathione reductase by NADPH and the protection as well as reactivation by GSSG play in vivo an important regulatory role. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUTATHIONE
KW  - LIVER
KW  - MICE as laboratory animals
KW  - AMMONIUM sulfate
KW  - ENZYMES
KW  - AFFINITY chromatography
N1  - Accession Number: 13682002; López-Barea, Juan 1 Chi-Yu Lee 2; Affiliation:  1: Departamento de Bioquímica, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain  2: Laboratory of Environmental Mutagenesis, National Institute of Environmental Health Sciences, Resarch Triangle  Park, North Carolina, USA; Source Info: 8/1/79, Vol. 98 Issue 2, p487; Subject Term: GLUTATHIONE; Subject Term: LIVER; Subject Term: MICE as laboratory animals; Subject Term: AMMONIUM sulfate; Subject Term: ENZYMES; Subject Term: AFFINITY chromatography; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325311 Nitrogenous Fertilizer Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, D. D.
AU  - Corash, L. M.
AU  - Kaliner, M.
T1  - Human platelet arylsulphatases: identification and capacity to destroy SRS-A.
JO  - Immunology
JF  - Immunology
Y1  - 1979/08//
VL  - 37
IS  - 4
M3  - Article
SP  - 723
EP  - 729
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Arylsulphatases IIA and IIB have been separately identified in human platelet s by use of anion exchange chromatography and gel filtration, Arylsulphatase IIA had a molecular weight of 160,000 and a pH optimum of 4.5. Arylsulphatase IIB had a molecular weight of 60,000 and a pH optimum of 5.5. Both arylsulphatases IIA and IIB were inhibited by phosphate and sulphate ions characteristic of this enzyme class. Platelets, upon exposure to ionophore A-23187 or thrombin, discharged arylsulphatase coincident with β-glucuronidase release. Partially purified platelet arylsulphatase lib inactivated rat SRS-A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ARYLSULFATASES
KW  - SULFATASES
KW  - ENZYMES
KW  - ENZYMOLOGY
KW  - BLOOD platelets
KW  - BIOCHEMISTRY
KW  - IMMUNOLOGY
N1  - Accession Number: 13987259; Metcalfe, D. D. 1,2 Corash, L. M. 1 Kaliner, M. 1; Affiliation:  1: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and the Hematology Service, Clinical Pathology Department, Clinical Center; National Institutes of Health, Bethesda, Maryland 20014, U.S.A.  2: Harvard Medical School, Robert B. Brigham Hospital, Boston, Massachusetts 02115, U.S.A.; Source Info: Aug79, Vol. 37 Issue 4, p723; Subject Term: ARYLSULFATASES; Subject Term: SULFATASES; Subject Term: ENZYMES; Subject Term: ENZYMOLOGY; Subject Term: BLOOD platelets; Subject Term: BIOCHEMISTRY; Subject Term: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Solomon, Lawrence M.
AU  - Kraemer, Kenneth H.
T1  - UV-A: Biological Effects of Ultraviolet Radiation with Emphasis on Human Response to Longwave Ultraviolet (Book).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1979/08//
VL  - 73
IS  - 2
M3  - Book Review
SP  - 202
EP  - 202
SN  - 0022202X
AB  - Reviews the book "UV-A: Biological Effects of Ultraviolet Radiation With Emphasis on Human Response to Longwave Ultraviolet," by John A. Parrish R. Rox Anderson, Frederick Urbach, and Donald Pitts.
KW  - ULTRAVIOLET radiation
KW  - NONFICTION
KW  - PARRISH, John A.
KW  - ANDERSON, R. Rox
KW  - PITTS, Donald
KW  - UV-A: Biological Effects of Ultraviolet Radiation With Emphasis on Human Responses to Longwave Ultraviolet (Book)
N1  - Accession Number: 12581693; Solomon, Lawrence M. Kraemer, Kenneth H. 1; Affiliation:  1: National Cancer Institute, Bethesda, Maryland.; Source Info: Aug79, Vol. 73 Issue 2, p202; Subject Term: ULTRAVIOLET radiation; Subject Term: NONFICTION; Reviews & Products: UV-A: Biological Effects of Ultraviolet Radiation With Emphasis on Human Responses to Longwave Ultraviolet (Book); People: PARRISH, John A.; People: ANDERSON, R. Rox; People: PITTS, Donald; Number of Pages: 1/3p; Document Type: Book Review
L3  - 10.1111/1523-1747.ep12581693
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2011-08425-011
AN  - 2011-08425-011
AU  - Caine, Eric D.
AU  - Mendelson, Wallace B.
AU  - Loriaux, D. Lynn
T1  - Neuroendocrine effects of haloperidol in an adolescent with Gilles de la Tourette's disease and delayed onset of puberty.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/08//
VL  - 167
IS  - 8
SP  - 504
EP  - 507
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Caine, Eric D., Department of Psychiatry, Neurology, and Pharmacology, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY, US, 14642
N1  - Accession Number: 2011-08425-011. PMID: 288847 Partial author list: First Author & Affiliation: Caine, Eric D.; Department of Psychiatry, Neurology, and Pharmacology, University of Rochester Medical Center, Rochester, NY, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Haloperidol; Neuroendocrinology; Tourette Syndrome. Minor Descriptor: Adolescent Development; Puberty. Classification: Neurological Disorders & Brain Damage (3297); Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200). Methodology: Clinical Case Study; Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Aug, 1979. Copyright Statement: The Williams & Wilkins Co. 1979. 
AB  - The effects of haloperidol on the release of prolactin, growth hormone, and luteinizing hormone during sleep were studied in an adolescent male who had Gilles de la Tourette's disease and delayed onset of puberty. At doses of 5 and 2 mg, haloperidol led to an increase of prolactin secretion and a suppression of luteinizing hormone release. Growth hormone was unaffected. Despite these changes, the patient had normal secondary sexual development consistent with puberty. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuroendocrinology
KW  - haloperidol
KW  - adolescent development
KW  - Gilles de la Tourette syndrome
KW  - puberty onset
KW  - 1979
KW  - Haloperidol
KW  - Neuroendocrinology
KW  - Tourette Syndrome
KW  - Adolescent Development
KW  - Puberty
KW  - 1979
DO  - 10.1097/00005053-197908000-00011
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06571-019
AN  - 2006-06571-019
AU  - Iverson, G. J.
T1  - Theorists Have a Field Day.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1979/08//
VL  - 24
IS  - 8
SP  - 640
EP  - 642
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06571-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Iverson, G. J.; National Eye Institute, New York University, New York, NY, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Stereoscopic Vision; Theories; Visual Field; Visual Perception. Classification: Visual Perception (2323). Population: Human (10). Reviewed Item: Leeuwenberg, E. L. J. (Ed); Buffart, H. F. J. M. (Ed). Formal Theories of Visual Perception=Chichester, England: Wiley, 1978. Pp. xii + 345. $37.50; 1978. Page Count: 3. Issue Publication Date: Aug, 1979. 
AB  - Reviews the book, Formal Theories of Visual Perception edited by E. L. J. Leeuwenberg and H. F. J. M. Buffart (1978). The volume has been somewhat arbitrarily divided into two sections, each containing eight articles. The first of these sections is entitled 'Theories on Field Effects,' and the second 'Coding Theories of Complex Patterns.' Although neither field effects nor coding is ever clearly denned, the following rule of thumb performs the classification. Lack of space prevents me from more than a brief review of content. By way of consolation perhaps, the book does possess an index! It is beautifully done, stocked with exotic entries such as 'interestingness,' 'random, dot stereopsis pattern,' and 'warning, system early' complete with elaborate cross referencing. Clearly my overall impressions of this book are very mixed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - formal theories
KW  - visual perception
KW  - complex patterns
KW  - coding theories
KW  - field effects
KW  - stereoscopic vision
KW  - 1979
KW  - Stereoscopic Vision
KW  - Theories
KW  - Visual Field
KW  - Visual Perception
KW  - 1979
U2  - Leeuwenberg, E. L. J. (Ed); Buffart, H. F. J. M. (Ed). (1978); Formal Theories of Visual Perception; Chichester, England: Wiley, 1978. Pp. xii + 345. $37.50
DO  - 10.1037/018782
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - CHO, HAN YONG
AU  - RHIM, JOHNG SIK
T1  - Cycloheximide-Dependent Reversion of Human Cells Transformed by MSV and Chemical Carcinogen.
JO  - Science
JF  - Science
Y1  - 1979/08/17/
VL  - 205
IS  - 4407
M3  - Article
SP  - 691
EP  - 693
SN  - 00368075
AB  - The protein syntthesis inhibitor cycloheximide, at a concentration of 0.08 microgram per milliliter, inducedflat morphology within 24 to 48 hours and low saturation density in human osteosarcoma cells transformed by Kirsten murine sarcoma virus (Ki-MSV) or N-methyl-N'-nitro-N-nitrosoguanidine. Removal of the protein synthesis inhibitor caused both transformed cells to revert to the transformed phenotype. The demonstration of cell-surface antigens, cross-reacted with antiserums induced by extracts of both types of transformed human cells, was dependent on the presence or absence of cycloheximide in the culture medium. The results show that protein synthesis is required to maintain the transformed state in virally or chemically transformed human cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269080; CHO, HAN YONG 1; RHIM, JOHNG SIK 2; Affiliations: 1: Department of Experimental Pathology, Walter Reed Army Institute of Research, Washington, D.C. 20012; 2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/17/1979, Vol. 205 Issue 4407, p691; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MACDONALD, J. FERGUSON
AU  - BARKER, JEFFERY L.
AU  - PAUL, STEVEN M.
AU  - MARANGOS, PAUL J.
AU  - SKOLNICK, PHILIP
T1  - Inosine May Be an Endogenous Ligand for Benzodiazepine Receptors on Cultured Spinal Neurons.
JO  - Science
JF  - Science
Y1  - 1979/08/17/
VL  - 205
IS  - 4407
M3  - Article
SP  - 715
EP  - 717
SN  - 00368075
AB  - Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepineflurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response 'which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269090; MACDONALD, J. FERGUSON 1; BARKER, JEFFERY L. 1; PAUL, STEVEN M. 2; MARANGOS, PAUL J. 2; SKOLNICK, PHILIP 3; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; 2: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 3: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolic, and Digestive Diseases, Bethesda, Maryland 20014; Issue Info: 8/17/1979, Vol. 205 Issue 4407, p715; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SCHWARTZ, WILLIAM J.
AU  - SMITH, CAROLYN B.
AU  - DAVIDSEN, LESLIE
AU  - SAVAKI, HELEN
AU  - SOKOLOFF, LOIJIS
AU  - MATA, MARINA
AU  - FINK, DAVID J.
AU  - GAINER, HAROLD
T1  - Metabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat.
JO  - Science
JF  - Science
Y1  - 1979/08/17/
VL  - 205
IS  - 4407
M3  - Article
SP  - 723
EP  - 725
SN  - 00368075
AB  - Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response tofunctional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269094; SCHWARTZ, WILLIAM J. 1; SMITH, CAROLYN B. 1; DAVIDSEN, LESLIE 1; SAVAKI, HELEN 1; SOKOLOFF, LOIJIS 1; MATA, MARINA 2; FINK, DAVID J. 2; GAINER, HAROLD 2; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda; Issue Info: 8/17/1979, Vol. 205 Issue 4407, p723; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - UPTON, ARTHUR C.
AU  - SHUBIK, PHILIPPE
AU  - CLAYSON, DAVID B.
T1  - NCI Bioassay Program.
JO  - Science
JF  - Science
Y1  - 1979/08/24/
VL  - 205
IS  - 4408
M3  - Article
SP  - 746
EP  - 747
SN  - 00368075
N1  - Accession Number: 85269096; UPTON, ARTHUR C. 1; SHUBIK, PHILIPPE 2; CLAYSON, DAVID B. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20205; 2: Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 42 and Dewey Avenue, Omaha, Nebraska 68105; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p746; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARALDI, M.
AU  - GUIDOTTI, A.
AU  - SCHWARTZ, J. P.
AU  - COSTA, E.
T1  - GABA Receptors in Clonal Cell Lines: A Model for Study of Benzodiazepine Action at Molecular Level.
JO  - Science
JF  - Science
Y1  - 1979/08/24/
VL  - 205
IS  - 4408
M3  - Article
SP  - 821
EP  - 823
SN  - 00368075
AB  - A "receptor unit" for y-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, andflunitrazepam) and a thermostable endogenotis protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB,(, neuroblastoina and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (I micromolar) prevents the effect of GABA modulin, and in turn GABA (0.1 millimolar) increases the binding of [3H]diazepam. The neuroblastoma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269121; BARALDI, M. 1; GUIDOTTI, A. 1; SCHWARTZ, J. P. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p821; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ESKAY, R. L.
AU  - BROWNSTEIN, M. J.
AU  - LONG, R. T.
T1  - α-Melanocyte-Stimulating Hormone: Reduction in Adult Rat Brain After Monosodium Glutamate Treatment of Neonates.
JO  - Science
JF  - Science
Y1  - 1979/08/24/
VL  - 205
IS  - 4408
M3  - Article
SP  - 827
EP  - 829
SN  - 00368075
AB  - Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in α 90 percent loss of ot-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of c-melanocyte-stimulating hormone in the brain suggests that its primary source there is the neuronal perikarya of the arcuate nucleus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269124; ESKAY, R. L. 1; BROWNSTEIN, M. J. 1; LONG, R. T. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p827; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BEACH, RAYMOND
T1  - Mosquitoes: Biting Behavior Inhibited by Ecdysone.
JO  - Science
JF  - Science
Y1  - 1979/08/24/
VL  - 205
IS  - 4408
M3  - Article
SP  - 829
EP  - 831
SN  - 00368075
AB  - Biting in Anopheles freeborni is inhibited during ovarian development. Biting inhibition is triggered by ecdysone, a hormone produced by the ovary during oogenesis. Biting inhibition does not occur in females after the removal of ovaries, but is restored by replacing ovaries or injecting ecdysone. Ecdysone also inhibits biting behavior when it is fed to females. This is the first example of ecdysone controlling a nonmolt-related behavior in insects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269125; BEACH, RAYMOND 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p829; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ANFINSEN, CHRISTIAN B.
AU  - CHAMBERLAIN, OWEN
AU  - DELBRÜCK, MAX
AU  - FLORY, PAUL J.
AU  - MCMILLAN, EDWIN M.
T1  - Scientific Ties and Human Rights.
JO  - Science
JF  - Science
Y1  - 1979/08/31/
VL  - 205
IS  - 4409
M3  - Article
SP  - 854
EP  - 855
SN  - 00368075
N1  - Accession Number: 85269127; ANFINSEN, CHRISTIAN B. 1; CHAMBERLAIN, OWEN 2; DELBRÜCK, MAX 3; FLORY, PAUL J. 4; MCMILLAN, EDWIN M. 5; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; 2: University of California, Berkeley 94720; 3: Argonne National Laboratory, Batavia, Illinois 60439; 4: Stanford University, Stanford, California 94305; 5: University of California, Berkeley; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p854; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MCCARTHY, CHARLES R.
T1  - Research Subjects: Rights and Regulations.
JO  - Science
JF  - Science
Y1  - 1979/08/31/
VL  - 205
IS  - 4409
M3  - Article
SP  - 855
EP  - 856
SN  - 00368075
N1  - Accession Number: 85269128; MCCARTHY, CHARLES R. 1; Affiliations: 1: Office for Protection from Research Risks, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p855; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BROZOSKI, THOMAS J.
AU  - BROWN, ROGER M.
AU  - ROSVOLD, H. E.
AU  - GOLDMAN, PATRICIA S.
T1  - Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey.
JO  - Science
JF  - Science
Y1  - 1979/08/31/
VL  - 205
IS  - 4409
M3  - Article
SP  - 929
EP  - 932
SN  - 00368075
AB  - Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269164; BROZOSKI, THOMAS J. 1; BROWN, ROGER M. 1; ROSVOLD, H. E. 1; GOLDMAN, PATRICIA S. 1; Affiliations: 1: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p929; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lum, L. G.
AU  - Muchmore, A. V.
AU  - Decker, Jean M.
AU  - Blaese, R. M.
T1  - MICC cytotoxic effector function of human T lymphocyte subpopulations bearing Fc-receptors for IgG and IgM.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1979/09//
VL  - 37
IS  - 3
M3  - Article
SP  - 558
EP  - 561
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Purified subpopulations of human T lymphocytes bearing Fc-IgG and Fc-IgM receptors were studied for their ability to mediate mitogen (PHA) induced cellular cytotoxicity (MICC) to chicken erythrocyte (CRBC) and DBA/Mastocytoma P815Y tumour cell targets. There were marked differences in the ability of the Fc-IgG receptor-bearing T cell (T γ) and the Fc-IgM (Tμ) to mediating MICC to CRBC and P815Y target cells, Tγ cells were very efficient killers of CRBC and Tμ cells had no cytotoxic activity to CRBC. On the other hand, both the Tγ and Tμ subpopulations were able to mediate MICC to P815Y tumour cell targets. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - MITOGENS
KW  - ERYTHROCYTES
KW  - T cells
KW  - TUMORS
KW  - CELLS
N1  - Accession Number: 15989068; Lum, L. G. 1 Muchmore, A. V. 1 Decker, Jean M. 1 Blaese, R. M. 1; Affiliation:  1: Metabolism Branch, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, USA.; Source Info: Sep1979, Vol. 37 Issue 3, p558; Subject Term: LYMPHOCYTES; Subject Term: MITOGENS; Subject Term: ERYTHROCYTES; Subject Term: T cells; Subject Term: TUMORS; Subject Term: CELLS; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dattner, Alan M.
AU  - Mann, Dean L.
AU  - Levis, William R.
T1  - Studies on the Contact Sensitization of Man with Simple Chemicals: V. Clonal Priming Allows Direct <em>in Vitro</em> Assessment of Autologous HLA-associated Factors Required for Immune Response to Dinitrochlorobenzene.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1979/09//
VL  - 73
IS  - 3
M3  - Article
SP  - 246
EP  - 249
SN  - 0022202X
AB  - Human lymphocytes from dinitrochlorobenzene (DNCB)-sensitized human subjects primed in first culture with dinitrophenylated-antigens yield a population of cells which respond in an accelerated manner to the same or similar antigen in second culture. Using this "clonal priming" approach, we have demonstrated that such a primed population showed maximal proliferative response to dinitrophenylated autologous cells. These DNP primed clones also showed responses to some dinitrophenylated allogeneic leukocytes. The magnitude of the accelerated blastogenic response with allogeneic leukocytes varied in most instances in relation to the degree of sharing of HLA-A, B, and DRw antigens with the original autologous stimulator. These findings show that the self-specific factors recognized in conjunction with the dinitrophenyl antigen are closely but not invariably associated with established major histocompatibility (MHC)-associated serologic typing results. While DNP primed clones fail to respond to unmodified autologous leukocytes, they often show significant responses to unmodified allogeneic leukocytes. If such accelerated responses to unmodified allogeneic leukocytes are not the result of nonspecific activation of allogeneic responding lymphocyte clones, these findings further indicate that DNP modified self can resemble some alloantigens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DINITROCHLOROBENZENE
KW  - IMMUNE response
KW  - TRANSFER factor (Immunology)
KW  - ANTIGENS
KW  - LYMPHOCYTES
KW  - CELL proliferation
N1  - Accession Number: 12514334; Dattner, Alan M. 1 Mann, Dean L. 1 Levis, William R. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep79, Vol. 73 Issue 3, p246; Subject Term: DINITROCHLOROBENZENE; Subject Term: IMMUNE response; Subject Term: TRANSFER factor (Immunology); Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12514334
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ware, James H.
T1  - Applications of Statistics (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1979/09//
VL  - 74
IS  - 367
M3  - Book Review
SP  - 735
SN  - 01621459
AB  - Reviews the book "Applications of Statistics," edited by Paruchuri R. Krishnaiah.
KW  - STATISTICS
KW  - NONFICTION
KW  - KRISHNAIAH, Parnchuri
KW  - KRISHNAIAH, Paruchuri R.
KW  - APPLICATIONS of Statistics (Book)
N1  - Accession Number: 4605637; Ware, James H. 1; Affiliations: 1: National Institutes of Health.; Issue Info: Sep79, Vol. 74 Issue 367, p735; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: APPLICATIONS of Statistics (Book); People: KRISHNAIAH, Parnchuri; People: KRISHNAIAH, Paruchuri R.; Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2011-08428-001
AN  - 2011-08428-001
AU  - Gordon, Malcolm A.
AU  - Greenspan, Stanley I.
T1  - A critique of ethological studies with children.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/09//
VL  - 167
IS  - 9
SP  - 519
EP  - 521
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Greenspan, Stanley I., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1  - Accession Number: 2011-08428-001. Partial author list: First Author & Affiliation: Gordon, Malcolm A.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Development; Observation Methods; Social Interaction; Intellectual Development Disorder. Minor Descriptor: Language Development; Parent Child Relations. Classification: Mental Retardation (3256). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Reviewed Item: Sackett, Gene P. (Ed). Observing behavior, Vol. I: Theory and applications in mental retardation=University Park Press, Baltimore, Vol. I: xv + 416 pp. $24.50; 1978. Sackett, Gene P. (Ed). Observing behavior, Vol. II: Data collection and analysis Methods=University Park Press, Baltimore, Vol. II: xiii + 110 pp. $12.50; 1978. Page Count: 3. Issue Publication Date: Sep, 1979. 
AB  - Reviews the book(s), Observing behavior, Vol. I: Theory and applications in mental retardation by Gene P. Sackett (see record [rid]1979-08721-000[/rid]) &Observing behavior,Vol. II: data collection and analysis Methods by Gene P. Sackett (see record [rid]1979-07552-000[/rid]). The papers in these two volumes are from a 1976 conference, 'Application of Observational-Ethological Methods to the Study of Mental Retardation.' The conference was jointly sponsored by the Mental Retardation Program of the National Institute of Child Health and Human Development and the Child Development and Mental Retardation Center of the University of Washington. It was convened to promote the study of the real world behavior of retarded persons in contrast to the more usual laboratory, questionnaire, and clinical studies. Volume I contains 17 papers describing observational methodology or reporting studies in parent-infant interaction, language development, cognitive development, and social interaction. Volume II contains six chapters on methodological and statistical considerations. In 'observational methods' a nonparticipant records the frequency and/ or duration of categorized behavioral events in natural human social settings. These volumes do succeed in giving a good overview of current methods of naturalistic quantitative observations and their relations to other methodologies. An added bonus is that several of the papers provide good overviews of substantive research areas and would be of interest to researchers outside the mental retardation field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - ethology
KW  - mental retardation
KW  - theory
KW  - applications
KW  - parent child interaction
KW  - social interaction
KW  - language development
KW  - cognitive development
KW  - behavior observation
KW  - 1979
KW  - Cognitive Development
KW  - Observation Methods
KW  - Social Interaction
KW  - Intellectual Development Disorder
KW  - Language Development
KW  - Parent Child Relations
KW  - 1979
U2  - Sackett, Gene P. (Ed). (1978); Observing behavior, Vol. I: Theory and applications in mental retardation; University Park Press, Baltimore, Vol. I: xv + 416 pp. $24.50
U2  - Sackett, Gene P. (Ed). (1978); Observing behavior, Vol. II: Data collection and analysis Methods; University Park Press, Baltimore, Vol. II: xiii + 110 pp. $12.50
DO  - 10.1097/00005053-197909000-00001
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08428-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-08428-008
AN  - 2011-08428-008
AU  - Tuma, A. Hussain
AU  - May, Philip R. A.
T1  - And if that doesn't work, what next … ? A study of treatment failures in schizophrenia.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/09//
VL  - 167
IS  - 9
SP  - 566
EP  - 571
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Tuma, A. Hussain, Clinical Research Branch, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, 5600 Fishers Lane, Room 10C-24, Rockville, MD, US, 20857
N1  - Accession Number: 2011-08428-008. PMID: 479870 Partial author list: First Author & Affiliation: Tuma, A. Hussain; Clinical Research Branch, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Rockville, MD, US. Release Date: 20110829. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Group Psychotherapy; Schizophrenia; Tranquilizing Drugs; Treatment Outcomes. Minor Descriptor: Failure. Classification: Schizophrenia & Psychotic States (3213); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Menninger Health-Sickness Rating Scale; MACC Behavioral Adjustment Scale. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 6. Issue Publication Date: Sep, 1979. Copyright Statement: Williams & Wilkins Co. 1979. 
AB  - A systematic study of schizophrenic patients who did not respond satisfactorily to one of five different forms of treatment given under controlled conditions showed that almost all of them responded satisfactorily to subsequent treatment with the combination of ataraxic drugs and group psychotherapy. Whatever the original form of treatment, and despite subsequent retreatment with drugs and group psychotherapy, there was a treatment- resistant core—a few patients who either responded very slowly or who improved relatively little. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment failures
KW  - schizophrenia
KW  - ataraxic drugs
KW  - group psychotherapy
KW  - 1979
KW  - Drug Therapy
KW  - Group Psychotherapy
KW  - Schizophrenia
KW  - Tranquilizing Drugs
KW  - Treatment Outcomes
KW  - Failure
KW  - 1979
U1  - Sponsor: State of California, Department of Mental Hygiene, US. Other Details: Research Service of the Veterans Administration. Recipients: No recipient indicated
U1  - Sponsor: United States Department of Health, Education, and Welfare, United States Public Health Service, National Institute of Mental Health, US. Grant: MH 02719; MH 04589; PH 43-66-49. Recipients: No recipient indicated
U1  - Sponsor: National Institutes of Health, US. Grant: RR-3. Other Details: Computing Facility at the Center for the Health Sciences, University of California at Los Angeles. Recipients: No recipient indicated
DO  - 10.1097/00005053-197909000-00008
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-08428-009
AN  - 2011-08428-009
AU  - Targum, Steven D.
AU  - Davenport, Yolande B.
AU  - Webster, Marian J.
T1  - Postpartum mania in bipolar manic-depressive patients withdrawn from lithium carbonate.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/09//
VL  - 167
IS  - 9
SP  - 572
EP  - 574
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Targum, Steven D., Psychiatric Institute, 4460 MacArthur Boulevard, N.W., Washington, DC, US, 20007
N1  - Accession Number: 2011-08428-009. PMID: 479871 Partial author list: First Author & Affiliation: Targum, Steven D.; National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Drug Withdrawal; Lithium Carbonate; Mania; Pregnancy. Minor Descriptor: Major Depression. Classification: Affective Disorders (3211). Population: Human (10); Female (40); Inpatient (50); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340). Methodology: Clinical Case Study; Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Sep, 1979. Copyright Statement: Williams & Wilkins Co. 1979. 
AB  - Three women, previously diagnosed as bipolar I manic-depressive, were withdrawn from lithium carbonate prophylaxis immediately prior to their pregnancies. The patients had been euthymic while on lithium carbonate for at least 3% years prior to their pregnancies. Two of the three patients developed a manic syndrome within 2 weeks postpartum. The use of lithium carbonate during pregnancy, and particularly in the postpartum period, requires reassessment. We advocate an ongoing clinical relationship and the reinstitution of lithium in the third trimester in most cases. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - postpartum mania
KW  - bipolar disorder
KW  - mania
KW  - lithium carbonate withdrawal
KW  - prophylaxis
KW  - pregnancy
KW  - manic depressive patients
KW  - 1979
KW  - Bipolar Disorder
KW  - Drug Withdrawal
KW  - Lithium Carbonate
KW  - Mania
KW  - Pregnancy
KW  - Major Depression
KW  - 1979
DO  - 10.1097/00005053-197909000-00009
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - COHEN, JACK S.
T1  - Aiding Vietnam.
JO  - Science
JF  - Science
Y1  - 1979/09/07/
VL  - 205
IS  - 4410
M3  - Article
SP  - 954
EP  - 954
SN  - 00368075
N1  - Accession Number: 85269168; COHEN, JACK S. 1; Affiliations: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 9/ 7/1979, Vol. 205 Issue 4410, p954; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GILLIN, J. CHRISTIAN
AU  - MENDELSON, WALLACE B.
AU  - DEMENT, WILLIAM C.
AU  - SOLOMON, FREDRIC
T1  - Flurazepam and Insomnia.
JO  - Science
JF  - Science
Y1  - 1979/09/07/
VL  - 205
IS  - 4410
M3  - Article
SP  - 954
EP  - 955
SN  - 00368075
N1  - Accession Number: 85269169; GILLIN, J. CHRISTIAN 1; MENDELSON, WALLACE B. 1; DEMENT, WILLIAM C. 2; SOLOMON, FREDRIC 3; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; 2: Stanford University Medical Center, Stanford, California 94305; 3: Institute of Medicine, National Academy of Sciences, Washington, D.C. 20418; Issue Info: 9/ 7/1979, Vol. 205 Issue 4410, p954; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOYD, SUELLYN C.
AU  - SASAME, HENRY A.
AU  - BOYD, MICHAEL R.
T1  - High Concentrations of Glutathione in Glandular Stomach: Possible Implications for Carcinogenesis.
JO  - Science
JF  - Science
Y1  - 1979/09/07/
VL  - 205
IS  - 4410
M3  - Article
SP  - 1010
EP  - 1012
SN  - 00368075
AB  - In laboratory rodents, concentrations of reduced glutathione (GSH) are exceedingly high (up to 7 to 8 millimolar) in the glandular gastric tissue compared to concentrations in other portions of the gastrointestinal tract or to those of most other organs. Gastric GSH varies diurnally, with the highest levels occurring in the late afternoon or early evening. Starvation, treatment with diethyl maleate, or cold-restraint stress all caused marked decreases in stomach GSH, whereas treatment with cobaltous chloride caused an increase in the GSH concentrations. The physiological significance of the high gastric GSH is unknown, but because this endogenous compound may strongly modulate (decrease or increase) the macromolecular binding of certain chemicals capable of inducing stomach tumors, the possible role of glutathione in the pathogenesis of chemically induced gastric cancer should be considered. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269201; BOYD, SUELLYN C. 1; SASAME, HENRY A. 2; BOYD, MICHAEL R. 3; Affiliations: 1: Field Studies and Statistics Program, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; 2: Lahoratory of Chemical Pharmacology, National Heart, Lung and Blood Institute, Bethesda, Maryland 20205; 3: Molecular Toxicology Section, Clinical Pharmacology Branch, National Cancer Institute; Issue Info: 9/ 7/1979, Vol. 205 Issue 4410, p1010; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KRETCHMER, NORMAN
AU  - HEGSTED, D. MARK
T1  - Nutrition Program.
JO  - Science
JF  - Science
Y1  - 1979/09/14/
VL  - 205
IS  - 4411
M3  - Article
SP  - 1083
EP  - 1084
SN  - 00368075
N1  - Accession Number: 85195799; KRETCHMER, NORMAN 1; HEGSTED, D. MARK 2; Affiliations: 1: National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Human Nutrition Center, Science and Education Administration, U.S. Department of Agriculture, Washington, D.C. 20250; Issue Info: 9/14/1979, Vol. 205 Issue 4411, p1083; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ISRAEL, MARK A.
AU  - CHAN, HARDY W.
AU  - MARTIN, MALCOLM A.
AU  - ROWE, WALLACE P.
T1  - Molecular Cloning of Polyoma Virus DNA in Escherichia coli: Oncogenicity Testing in Hamsters.
JO  - Science
JF  - Science
Y1  - 1979/09/14/
VL  - 205
IS  - 4411
M3  - Article
SP  - 1140
EP  - 1142
SN  - 00368075
AB  - Inoculation of suckling hamsters with 2 X 108 live cells of Escherichia coli K12 strain xI 776, carrying the complete genome of polyoma virus in a recombinant plasmid, failed to induce tumors in any of 32 recipients. Also, lambda phage DNA and particles with a monomeric insert of polyoma DNA did not induce tumors. Purified recombinant plasmid DNA, as well as phage particles and DNA containing a head-to-tail dimer of polyoma DNA, showed a low degree of oncogenicity, comparable to that of polyoma DNA prepared from mouse cells. These findings support the previous conclusions, based on infectivity assays in mice, that propagation of polyoma virus DNA as a component of recombinant DNA molecules in E. coli K12 reduces its biologic activity many orders of magnitude relative to the virus itself. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85195825; ISRAEL, MARK A. 1; CHAN, HARDY W. 1; MARTIN, MALCOLM A. 1; ROWE, WALLACE P. 2; Affiliations: 1: Recombinant DNA Research Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 9/14/1979, Vol. 205 Issue 4411, p1140; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHO-CHUNG, YOON SANG
AU  - ARCHIBALD, DAVID
AU  - CLAIR, TIMoTHY
T1  - Cyclic AMP Receptor Triggers Nuclear Protein Phosphorylation in a Hormone-Dependent Mammary Tumor Cell-Free System.
JO  - Science
JF  - Science
Y1  - 1979/09/28/
VL  - 205
IS  - 4413
M3  - Article
SP  - 1390
EP  - 1392
SN  - 00368075
AB  - Adenosine 3',5'-monophosphate (cyclic AMP) receptor protein of 56,000 daltons increases markedly in mammary tumors induced by 7,12-dimethylbenz[ a]anthracene (DMBA) after incubation of tumor slices with cyclic AMP, benzamidine, and arginine. Incubation of cytosol from these tumor slices with nuclei from unincubated tumors results in nuclear uptake of the 56,000-dalton cyclic AMP receptor and in phosphorylation of the 76,000-dalton nuclear protein. Binding of the 56,000-dalton receptor and phosphorylation of the 76,000-dalton protein also occur in DMBA tumor nuclei when protein kinase type II of bovine heart is used. The results suggest that cyclic AMP receptor is involved in the nuclear events of a hormone- dependent mammary tumor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269249; CHO-CHUNG, YOON SANG 1; ARCHIBALD, DAVID 1; CLAIR, TIMoTHY 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 9/28/1979, Vol. 205 Issue 4413, p1390; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rogan, Walter J.
T1  - OVERVIEW OF ENVIRONMENTALISM.
JO  - BioScience
JF  - BioScience
Y1  - 1979/10//
VL  - 29
IS  - 10
M3  - Book Review
SP  - 623
EP  - 623
SN  - 00063568
AB  - The article reviews the book "Environment, Technology, and Health: Human Ecology in Historical Perspective," by Merril Eisenbud.
KW  - Environmentalism
KW  - Nonfiction
KW  - Eisenbud, Merril
KW  - Environment, Technology & Health: Human Ecology in Historical Perspective (Book)
N1  - Accession Number: 28050922; Rogan, Walter J. 1; Affiliations: 1 : National Institute of Environmental Health Sciences Research Triangle Park, NC;  Source Info: Oct1979, Vol. 29 Issue 10, p623; Thesaurus Term: Environmentalism; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 676
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Hirschfeld, Robert M. A.
AU  - Klerman, Gerald L.
T1  - Treatment of depression in the elderly.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1979/10//
VL  - 34
IS  - 10
M3  - Article
SP  - 51
EP  - 57
SN  - 0016867X
N1  - Accession Number: 18936381; Hirschfeld, Robert M. A. 1; Klerman, Gerald L. 2; Source Information: Oct1979, Vol. 34 Issue 10, p51; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 3091
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2013-42799-024
AN  - 2013-42799-024
AU  - Curtz, Elisabeth R.
AU  - Trickett, Penelope K.
T1  - Review of Social change and human purpose: Toward understanding and action.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1979/10//
VL  - 49
IS  - 4
SP  - 724
EP  - 727
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42799-024. Partial author list: First Author & Affiliation: Curtz, Elisabeth R.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Nature; Social Change; Social Issues; Social Sciences. Minor Descriptor: Experimentation; Social Justice. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Warren, Roland L. Social change and human purpose: Toward understanding and action=348 pp. $11.50. Rand McNally, Chicago; 1977. Page Count: 4. Issue Publication Date: Oct, 1979. 
AB  - Reviews the book, Social change and human purpose: Toward understanding and action by Roland L. Warren (1977). Warren's book is like an oasis in the desert. In a brief space it brings order and life to innumerable particles of social science theory and research. The particular strength of the book is Warren's talent for describing very complex and intertwined situations in a clear and simple way, and doing so without minimizing their complexity. The volume is designed as a student text, and as such has a number of advantages for the general reader. The text draws heavily on the full range of relevant literature for both discussion and example. The organizing tool that Warren develops in the book is a six-part descriptive model. The second half of the book is devoted to consideration of these broader strategic questions at the three different target-system levels. Warren has no easy answers for the multitude of difficult problems which his book brings into focus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social change
KW  - human purpose
KW  - social science theory
KW  - research
KW  - difficult problems
KW  - 1979
KW  - Human Nature
KW  - Social Change
KW  - Social Issues
KW  - Social Sciences
KW  - Experimentation
KW  - Social Justice
KW  - 1979
U2  - Warren, Roland L. (1977); Social change and human purpose: Toward understanding and action; 348 pp. $11.50. Rand McNally, Chicago
DO  - 10.1037/h0098986
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - TALBOT, BERNARD
T1  - Recombinant DNA Rules.
JO  - Science
JF  - Science
Y1  - 1979/10/05/
VL  - 206
IS  - 4414
M3  - Article
SP  - 9
EP  - 9
SN  - 00368075
N1  - Accession Number: 85195882; TALBOT, BERNARD 1; Affiliations: 1: Office, Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/ 5/1979, Vol. 206 Issue 4414, p9; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BINDERMAN, I.
AU  - GREENE, R. M.
AU  - PENNYPACKER, J. P.
T1  - Calcification of Differentiating Skeletal Mesenchyme in vitro.
JO  - Science
JF  - Science
Y1  - 1979/10/12/
VL  - 206
IS  - 4415
M3  - Article
SP  - 222
EP  - 225
SN  - 00368075
AB  - Embryonic limb-bud mesenchyme was induced to calcify in culture by the addition of 3 mM inorganic phosphate to the medium. Phosphate enhanced calcification of the matrix produced by mesenchymal orfibroblast-like cells, whereas no calcification was evident in areas where cartilage had developed. However, calcification was induced throughout the cell layer by altering the cartilage matrix properties with certain enzymes or by changing the phenotypic expression of the cells with vitamin A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85195961; BINDERMAN, I. 1; GREENE, R. M. 1; PENNYPACKER, J. P. 1; Affiliations: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/12/1979, Vol. 206 Issue 4415, p222; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - William, Leah A.
AU  - Piatigorsky, Joran
T1  - Comparative and Evolutionary Aspects of ℘-Crystallin in the Vertebrate Lens.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1979/10/15/
VL  - 100
IS  - 2
M3  - Article
SP  - 349
EP  - 357
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have utilized [3H]cDNA · DNA annealing (using S1 endonuclease resistance as an assay) to detect the presence of sequences complementary to chick δ-crystallin mRNA in the genome of fish (salmon, herring), amphibians (frog, newt), reptiles (python, gekko, caiman), birds (quail, turkey, duck), and mammals (mouse, calf), and have compared several physical parameters of δ-crystallin of the reptiles and birds. The rate and extent of chick δ-crystallin [3H]cDNA · DNA annealing were comparable among the birds, and indicated that the δ-crystallin sequences are in the unique fraction of the genome. On the average, about one-fifth as much annealing took place with the reptiles as with the birds, and no annealing was observed with the fish, amphibians and mammals. The avian and reptilian δ-crystallins had subunit molecular weights near 50000 and native molecular weights near 200000, as judged by sodium dodecylsulfate/urea/polyacrylamide gel electrophoresis and agarose gel chromatography, respectively, indicating that the subunit structure of δ-crystallin has been largely conserved. Electrophoresis of the peptides generated by digestion with Staphylococcus aureus V8 protease indicated that the primary structures of the different reptilian and avian δ-crystallins were similar but not identical. The isoelectric points of the δ-crystallins ranged between pH 5 and 7, depending on the organism. In general, the reptilian δ-crystallins had the higher isoelectric points. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - GENOMES
KW  - AMPHIBIANS
KW  - CHROMATOGRAPHIC analysis
KW  - STAPHYLOCOCCUS aureus
KW  - PEPTIDES
KW  - ELECTROPHORESIS
N1  - Accession Number: 13686733; William, Leah A. 1 Piatigorsky, Joran 1; Affiliation:  1: Section on Cellular Differentiation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Devleopment, National Institutes of Health, Bethesda, Maryland; Source Info: 10/15/79, Vol. 100 Issue 2, p349; Subject Term: DNA; Subject Term: GENOMES; Subject Term: AMPHIBIANS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: PEPTIDES; Subject Term: ELECTROPHORESIS; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - POTKIN, STEVEN G.
AU  - KAROUM, FAROUK
AU  - LIN-WHEI CHUANG
AU  - CANNON-SPOOR, H. E.
AU  - PHILLIPS, INGRID
AU  - WYATT, RICHARD JED
T1  - Phenylethylamine in Paranoid Chronic Schizophrenia.
JO  - Science
JF  - Science
Y1  - 1979/10/26/
VL  - 206
IS  - 4417
M3  - Article
SP  - 470
EP  - 471
SN  - 00368075
AB  - Phenylethylamine (PEA) is an endogenous amine that is structurally and pharmacologically related to amphetamine. Urinary PEA excretion is significantly higher in paranoid chronic schizophrenics than in nonparanoid chronic schizophrenics and normal controls. Diet, hospitalization, and medication do not account for differences in PEA concentrations. These findings offer some indication that PEA may be an endogenous amphetamine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158975; POTKIN, STEVEN G. 1; KAROUM, FAROUK 1; LIN-WHEI CHUANG 1; CANNON-SPOOR, H. E. 1; PHILLIPS, INGRID 1; WYATT, RICHARD JED 1; Affiliations: 1: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washlngton, D.C. 20032; Issue Info: 10/26/1979, Vol. 206 Issue 4417, p470; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KLEINMAN, JOEL E.
AU  - POTKIN, STEVEN
AU  - ALAN ROGOL, ALAN
AU  - BUCHSBAUM, MONTE S.
AU  - MURPHY, DENNIS L.
AU  - GILLIN, J. CHRISTIAN
AU  - NASRALLAH, HENRY A.
AU  - WYATT, RICHARD JED
T1  - A Correlation Between Platelet Monoamine Oxidase Activity and Plasma Prolactin Concentrations in Man.
JO  - Science
JF  - Science
Y1  - 1979/10/26/
VL  - 206
IS  - 4417
M3  - Article
SP  - 479
EP  - 481
SN  - 00368075
AB  - Increases in plasma prolactin concentrations produced by a-methyl-ptyrosine, a catecholamine synthesis inhibitor, varied inversely with baseline platelet monoamine oxidase activity in 12 patients with chronic schizophrenia. In normal volunteers with low monoamine oxidase activity and in unmedicated patients with chronic schizophrenia, plasma prolactin concentrations varied directly with platelet monoamine oxidase activity. No such relationship wasfound in normal subjects with high platelet monoamine oxidase activity. These data suggest that platelet monoamine oxidase activity reflects monoaminergic activity in the tubero-infundibular system, which in turn affects plasma prolactin concentrations. This relationship may be important in patients with low platelet monoamine oxidase activity, such as some chronic schizophrenics. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85158980; KLEINMAN, JOEL E. 1; POTKIN, STEVEN 1; ALAN ROGOL, ALAN 2; BUCHSBAUM, MONTE S. 3; MURPHY, DENNIS L. 4; GILLIN, J. CHRISTIAN 5; NASRALLAH, HENRY A. 5; WYATT, RICHARD JED 5; Affiliations: 1: Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pediatrics, University of Virginia Medical Center, Charlottesville 22908; 3: Laboratory of Clinical Psychophysiology, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Laboratory of Neuropharmacology, National Institute of Mental Health; 5: Laboratory of Clinical Psychopharmacology, Saint Elizabeths Hospital; Issue Info: 10/26/1979, Vol. 206 Issue 4417, p479; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - JACKSON, TOGWELL A.
AU  - WELLNER, DANIEL
AU  - BONDY, STEPHEN C.
T1  - Stereospecific Sorption of L Amino Acids by Colloidal Clay.
JO  - Science
JF  - Science
Y1  - 1979/10/26/
VL  - 206
IS  - 4417
M3  - Article
SP  - 483
EP  - 484
SN  - 00368075
N1  - Accession Number: 85158982; JACKSON, TOGWELL A. 1; WELLNER, DANIEL 2; BONDY, STEPHEN C. 3; Affiliations: 1: Freshwater Institute, 501 Universtiy Crescent, Winnipeg, Manitoba, R3T 2N6 Canada; 2: Department of Biochemistry, Cornell University Medical College, News York 10021; 3: Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 10/26/1979, Vol. 206 Issue 4417, p483; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Coulter, Charles L.
T1  - Instrument Needs in Biology.
JO  - BioScience
JF  - BioScience
Y1  - 1979/11//
VL  - 29
IS  - 11
M3  - Article
SP  - 678
EP  - 680
SN  - 00063568
AB  - The article presents detailed information on scientific instruments needed in biological research. A recent study suggests that the effects of a deteriorating instrument base are being felt in a variety of ways in all of experimental science. A survey by the U.S. National Science Foundation showed that the cost of scientific instruments in five basic science areas had increased fourfold since 1970. New instruments such as cell sorters and new technologies such as computer modeling of populations and image analysis have recently been applied creatively in biology. The need for these and other new tools is growing, and biologists are becoming more dependent on these tools in their investigations.
KW  - Biologists
KW  - Scientific apparatus & instruments
KW  - Biological research
KW  - Research -- Equipment & supplies
KW  - Surveys
KW  - Medical technology
KW  - Image analysis
KW  - Flow cytometry
KW  - United States
KW  - National Science Foundation (U.S.)
N1  - Accession Number: 28049978; Coulter, Charles L. 1; Affiliations: 1 : Head of the Biological Structure Section, Biotechnology Resources Program, Division of Research Resources, National Institutes of Health, Bethesda, MD 20205;  Source Info: Nov1979, Vol. 29 Issue 11, p678; Thesaurus Term: Biologists; Subject Term: Scientific apparatus & instruments; Subject Term: Biological research; Subject Term: Research -- Equipment & supplies; Subject Term: Surveys; Subject Term: Medical technology; Subject Term: Image analysis; Subject Term: Flow cytometry; Subject: United States; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2984
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DP  - EBSCOhost
DB  - 8gh
ER  - 
TY  - JOUR
AU  - Adler, W. H.
T1  - CELL BIOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1979/11//
VL  - 29
IS  - 11
M3  - Book Review
SP  - 682
EP  - 682
SN  - 00063568
AB  - The article reviews the book "Stem Cells and Tissue Homeostasis," edited by B. I. Lord, C. S. Rotten, and R. J. Cole.
KW  - Stem cells
KW  - Nonfiction
KW  - Lord, B. I.
KW  - Rotten, C. S.
KW  - Cole, R. J.
KW  - Stem Cells & Tissue Homeostasis (Book)
N1  - Accession Number: 28049981; Adler, W. H. 1; Affiliations: 1 : National Institute on Aging, Gerontology Research Center, Baltimore City Hospital, Baltimore, MD 21224;  Source Info: Nov1979, Vol. 29 Issue 11, p682; Subject Term: Stem cells; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 551
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Levenbook, L.
T1  - INSECT BIOCHEMISTRY.
JO  - BioScience
JF  - BioScience
Y1  - 1979/11//
VL  - 29
IS  - 11
M3  - Book Review
SP  - 689
EP  - 689
SN  - 00063568
AB  - The article reviews the book "Biochemistry of Insects," edited by Morris Rockstein.
KW  - Insects
KW  - Nonfiction
KW  - Rockstein, Morris
KW  - Biochemistry of Insects (Book)
N1  - Accession Number: 28049990; Levenbook, L. 1; Affiliations: 1 : National Institutes of Health, Laboratory of Physical Biology, Bethesda, Md 20205;  Source Info: Nov1979, Vol. 29 Issue 11, p689; Thesaurus Term: Insects; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 647
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Lipkin, Lewis E.
T1  - IMAGE ANALYSIS.
JO  - BioScience
JF  - BioScience
Y1  - 1979/11//
VL  - 29
IS  - 11
M3  - Book Review
SP  - 691
EP  - 691
SN  - 00063568
AB  - The article reviews the book "Image Analysis, Enhancement and Interpretation," Volume 7 "Practical Methods in Electron Microscopy," by D. L. Misell.
KW  - Electron microscopy
KW  - Nonfiction
KW  - Misell, D. L.
KW  - Image Analysis, Enhancement & Interpretation: Practical Methods in Electron Microscopy (Book)
N1  - Accession Number: 28049993; Lipkin, Lewis E. 1; Affiliations: 1 : National Cancer Institute, National Institutes of Health, Bethesda, MD 20205;  Source Info: Nov1979, Vol. 29 Issue 11, p691; Subject Term: Electron microscopy; Subject Term: Nonfiction; Number of Pages: 2/3p; Document Type: Book Review; Full Text Word Count: 760
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - GEN
AU  - Hearing, Vincent J.
T1  - TYROSINE HYDROXYLATION.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1979/11//
VL  - 73
IS  - 5 Part 1
M3  - Letter
SP  - 392
EP  - 393
SN  - 0022202X
AB  - Presents a letter to the editor related to tyrosine hydroxylation.
KW  - TYROSINE
KW  - LETTERS to the editor
N1  - Accession Number: 12551743; Hearing, Vincent J. 1; Affiliation:  1: Senior Investigator, Dermatology Branch, National Cancer Institute.; Source Info: Nov79, Vol. 73 Issue 5 Part 1, p392; Subject Term: TYROSINE; Subject Term: LETTERS to the editor; Number of Pages: 2p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12551743
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gottlieb, Sheldon H.
AU  - Engel, Bernard T.
T1  - Autonomic Interactions in the Control of Heart Rate in the Monkey.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1979/11//
VL  - 16
IS  - 6
M3  - Article
SP  - 528
EP  - 536
SN  - 00485772
AB  - Each of 5 monkeys (Macaca mulatta) was operantly conditioned to raise and to lower heart rate consistently and reliably. Following such training the animals were tested using autonomic blocking agents (methyl-atropine bromide and l-propranolol) to characterize the autonomic mechanisms mediating such control. The results were: 1) In the undrngged animal the extent to which it decreases its heart rate over a 2048-sec period is a linear function of the baseline heart rate; 2) A linear relationship between baseline heart rate and heart rate decrease also is present within the first 128 sec; 3) There is a less consistent relationship between baseline heart rate and change in heart rate when animals must increase heart rate; 4) Vagal blockade significantly attenuates the ability of most animals to increase heart rate, primarily by reducing their ability to produce large, relatively rapid increases; 5) Sympathetic blockade significantly attenuates the ability of most animals to increase heart rate both in terms of overall changes and in terms of large, relatively rapid responses; 6) Vagal blockade very significantly attenuates the ability of all animals to slow heart rate; 7) Sympathetic blockade facilitates the ability of most animals to slow heart rate. These findings show that both branches of the autonomic nervous system participate in the operant control of heart rate. The relative role of one branch or the other in a given experiment will depend upon the baseline conditions at the time of testing, and upon the requirements -- i.e., raising or lowering of heart rate. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHESUS monkey
KW  - HEART beat
KW  - OPERANT conditioning
KW  - CONDITIONED response
KW  - AUTONOMIC nervous system
KW  - ATROPINE
KW  - Atropine.
KW  - Autonomic nervous system
KW  - Heart rate
KW  - Intrinsic heart rate
KW  - Monkeys
KW  - Operant conditioning
N1  - Accession Number: 11196996; Gottlieb, Sheldon H. 1 Engel, Bernard T. 2; Affiliation:  1: Department of Medicine, Division of Cardiology, Baltimore City Hospitals, and The Johns Hopkins  University School of Medicine.  2: Gerontology Research Center (Baltimore), National Institute on Aging, National Institutes of Health,  P11 5,  U.S. Department of Health, Education, and Welfare, Bethesda, and The Baltimore  City Hospitals, Baltimore, and The Johns Hopkins  University School of Medicine.; Source Info: Nov1979, Vol. 16 Issue 6, p528; Subject Term: RHESUS monkey; Subject Term: HEART beat; Subject Term: OPERANT conditioning; Subject Term: CONDITIONED response; Subject Term: AUTONOMIC nervous system; Subject Term: ATROPINE; Author-Supplied Keyword: Atropine.; Author-Supplied Keyword: Autonomic nervous system; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Intrinsic heart rate; Author-Supplied Keyword: Monkeys; Author-Supplied Keyword: Operant conditioning; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-8986.ep11196996
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2011-08309-019
AN  - 2011-08309-019
AU  - Gaarder, Kenneth
T1  - Review of Normal psychology of the aging process.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1979/11//
VL  - 167
IS  - 11
SP  - 716
EP  - 717
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
N1  - Accession Number: 2011-08309-019. Partial author list: First Author & Affiliation: Gaarder, Kenneth; National Institute on Aging, Bethesda, MD, US. Release Date: 20111219. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Gerontology; Geropsychology; Physiological Aging; Psychology. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Reviewed Item: Zinberg, Norman E. (Ed); Kaufman, Irving (Ed). Normal psychology of the aging process=Rev. International Universities Press, New York, xxiii + 285 pp. $15.00; 1978. Page Count: 2. Issue Publication Date: Nov, 1979. Copyright Statement: The Williams & Wilkins Co. 1979. 
AB  - Reviews the book, Normal Psychology of the Aging Process edited by Norman E. Zinberg and Irving Kaufman (see record [rid]1979-30664-000[/rid]). This is a revised and expanded version of the Boston Society for Gerontological Psychiatry Conference proceedings published in 1963. This book and its original version are both guaranteed a place within the structure of general and psychoanalytic knowledge of aging, since they represent the thoughts of respected and experienced clinicians who are knowledgeable about both patients and psychoanalysis. When the proceedings were first published, the study of normal aging was only beginning to interest investigators and clinicians. As aging research comes to command the attention it deserves, readers who consider this their area of focus should be aware of Zinberg and Kaufman's book. For the already knowledgeable gerontologist, however, the clinical examples and the range of issues covered provide little that has not now been considered. For the clinician or student wishing an introduction to geriatrics and gerontology or to the narrower focus of the normal psychology of aging, there are many better textbooks. This is a book which is less important now than when the first edition was published. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - gerontology
KW  - geriatrics
KW  - aging
KW  - psychology
KW  - 1979
KW  - Gerontology
KW  - Geropsychology
KW  - Physiological Aging
KW  - Psychology
KW  - 1979
U2  - Zinberg, Norman E. (Ed); Kaufman, Irving (Ed). (1978); Normal psychology of the aging process; Rev. International Universities Press, New York, xxiii + 285 pp. $15.00
DO  - 10.1097/00005053-197911000-00019
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - BROWN, NIGEL A.
AU  - GOULDING, EUGENIA H.
AU  - FABRO, SERGIO
T1  - Ethanol Embryotoxicity: Direct Effects on Mammalian Embryos in vitro.
JO  - Science
JF  - Science
Y1  - 1979/11/02/
VL  - 206
IS  - 4418
M3  - Article
SP  - 573
EP  - 575
SN  - 00368075
AB  - Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic-features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethano, which causes reduced embryonic cellular proliferation early in gestation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437582; BROWN, NIGEL A. 1,2; GOULDING, EUGENIA H. 3; FABRO, SERGIO 1,4; Affiliations: 1: Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Department of Pharmacology, George Washington University Medical Center, Washington, D.C. 20037; 3: Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences; 4: Departments of Pharmacology and Obstetrics and Gynecology, George Washington University Medical Center; Issue Info: 11/ 2/1979, Vol. 206 Issue 4418, p573; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NIJHOUT, H. FREDERIK
AU  - SHEFFIELD, HARLEY G.
T1  - Antennal Hair Erection in Male Mosquitoes: A New Mechanical Effector in Insects.
JO  - Science
JF  - Science
Y1  - 1979/11/02/
VL  - 206
IS  - 4418
M3  - Article
SP  - 595
EP  - 596
SN  - 00368075
AB  - Male Anopheles mosquitoes erect their antennal hairs prior to mating. The erectile mechanism resides in a unique annulus at the base of each hair whorl. It appears that the insect regulates the degree of hydration of this annulus. When the annulus is made to swell the attached hairs are pushed to their erect position. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437592; NIJHOUT, H. FREDERIK 1,2; SHEFFIELD, HARLEY G. 2; Affiliations: 1: Department of Zoology, Duke University, Durham, North Carolina 27706; 2: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/ 2/1979, Vol. 206 Issue 4418, p595; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEBBER, RICHARD L.
AU  - BLUM, HARRY
T1  - Angular Invariants in Developing Human Mandibles.
JO  - Science
JF  - Science
Y1  - 1979/11/09/
VL  - 206
IS  - 4419
M3  - Article
SP  - 689
EP  - 691
SN  - 00368075
AB  - Recent studies of lateral cephalograms based on symmetric-axis analyses of the mandibular border yield angles that appear to be uninfluenced by gross changes in mandibular shape over age and between individuals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159016; WEBBER, RICHARD L. 1; BLUM, HARRY 2; Affiliations: 1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; 2: Division of Computer Research and Technology, National Institutes of Health; Issue Info: 11/ 9/1979, Vol. 206 Issue 4419, p689; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEHR, THOMAS A.
AU  - WIRZ-JUSTICE, ANNA
AU  - GOODWIN, FREDERICK K.
AU  - DUNCAN, WALLACE
AU  - GILLIN, J. CHRISTIAN
T1  - Phase Advance of the Circadian Sleep-Wake Cycle as an Antidepressant.
JO  - Science
JF  - Science
Y1  - 1979/11/09/
VL  - 206
IS  - 4419
M3  - Article
SP  - 710
EP  - 713
SN  - 00368075
AB  - Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159025; WEHR, THOMAS A. 1; WIRZ-JUSTICE, ANNA 1; GOODWIN, FREDERICK K. 1; DUNCAN, WALLACE 2; GILLIN, J. CHRISTIAN 2; Affiliations: 1: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 11/ 9/1979, Vol. 206 Issue 4419, p710; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FREED, WILLIAM J.
AU  - PERLOW, MARK J.
AU  - WYATT, RICHARD JED
T1  - Calcitonin: Inhibitory Effect on Eating in Rats.
JO  - Science
JF  - Science
Y1  - 1979/11/16/
VL  - 206
IS  - 4420
M3  - Article
SP  - 850
EP  - 852
SN  - 00368075
AB  - Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159063; FREED, WILLIAM J. 1; PERLOW, MARK J.; WYATT, RICHARD JED; Affiliations: 1: Unit, Geriatric Psychiatry, Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, Intramural Research Program, National institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 11/16/1979, Vol. 206 Issue 4420, p850; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHIRO, GIOVANNI DI
AU  - BROOKS, RODNEY A.
T1  - The 1979 Nobel Prize in Physiology or Medicine.
JO  - Science
JF  - Science
Y1  - 1979/11/30/
VL  - 206
IS  - 4422
M3  - Article
SP  - 1060
EP  - 1062
SN  - 00368075
N1  - Accession Number: 85361581; CHIRO, GIOVANNI DI 1; BROOKS, RODNEY A. 1; Affiliations: 1: Neuroradiology and Computed Tomography Section, Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/30/1979, Vol. 206 Issue 4422, p1060; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - RABINOVITZ, MARCO
AU  - UEHARA, YOSHIMASA
AU  - VISTICA, DAVID T.
T1  - Differential Competition with Cytotoxic Agents: An Approach to Selectivity in Cancer Chemotherapy.
JO  - Science
JF  - Science
Y1  - 1979/11/30/
VL  - 206
IS  - 4422
M3  - Article
SP  - 1085
EP  - 1087
SN  - 00368075
AB  - An approach to increasing the selectivity of cancer chemotherapeutic agents is presented in which noncytotoxic competitive substrates are used to discern the differences in structural requirements for transport of cytotoxic agents between tumor cells and a sensitive host tissue, the hematopoietic precursor cells of the bone marrow. Examples are given for two such systems, one responsible for the transport of nucleosides and another for the transport of amino acids. Cytidine is twice as effective in reducing the toxicity of showdomycin for murine bone marrow cells in culture as it is for murine L1210 leukemia cells. Conversely, homoleucine is twice as effective in reducing the toxicity of melphalan for L1210 cells as it is for bone marrow cells. These observations can serve as a basis for the development of bone marrow protective agents and for the design of cytotoxic agents that may be preferentially transported into tumor cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361596; RABINOVITZ, MARCO 1; UEHARA, YOSHIMASA 1; VISTICA, DAVID T. 1; Affiliations: 1: Laboratory of Medicinal Chemistry and Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 11/30/1979, Vol. 206 Issue 4422, p1085; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rosenberg, Martin
AU  - Court, Donald
T1  - REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1979/12//
VL  - 13
M3  - Article
SP  - 319
EP  - 353
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Evaluates he DNA sequences involved in the promotion and termination of RNA transcription.  Characterization of the promoter and terminator site mutations; Correlation of the structural and functional similarities and differences occurring in regulatory site; Influence to the interaction between polymerase and DNA.
KW  - NUCLEOTIDE sequence
KW  - MUTATION (Biology)
KW  - DNA polymerases
KW  - RNA
N1  - Accession Number: 12409210; Rosenberg, Martin 1 Court, Donald; Affiliation:  1: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 1979, Vol. 13, p319; Subject Term: NUCLEOTIDE sequence; Subject Term: MUTATION (Biology); Subject Term: DNA polymerases; Subject Term: RNA; Number of Pages: 35p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Evans, V. Jeffery
AU  - Macdonald, H. Malcolm
T1  - Family and Population in Nineteenth-Century America.
JO  - Social Science Quarterly (University of Texas Press)
JF  - Social Science Quarterly (University of Texas Press)
Y1  - 1979/12//
VL  - 60
IS  - 3
M3  - Book Review
SP  - 541
EP  - 542
PB  - University of Texas Press
SN  - 00384941
AB  - Reviews the book "Family and Population in Nineteenth-Century America," edited by Tamara K. Hareven and Maris A. Vinovskis.
KW  - FAMILIES
KW  - NONFICTION
KW  - HAREVEN, Tamara K.
KW  - VINOVSKIS, Maris A.
KW  - FAMILY & Population in Nineteenth-Century America (Book)
N1  - Accession Number: 16557750; Evans, V. Jeffery 1 Macdonald, H. Malcolm; Affiliation:  1: Center for Population Research National Institute for Child Health and Human Development; Source Info: Dec1979, Vol. 60 Issue 3, p541; Subject Term: FAMILIES; Subject Term: NONFICTION; Reviews & Products: FAMILY & Population in Nineteenth-Century America (Book); People: HAREVEN, Tamara K.; People: VINOVSKIS, Maris A.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - JEFFREY, A. M.
AU  - GRZESKOWIAK, K.
AU  - WEINSTEIN, I. B.
AU  - NAKANISHI, K.
AU  - ROLLER, P.
AU  - HARVEY, R. G.
T1  - Benzo(a)pyrene-7,8-dihydrodiol 9,10-Oxide Adenosine and Deoxyadenosine Adducts: Structure and Stereochemistry.
JO  - Science
JF  - Science
Y1  - 1979/12/14/
VL  - 206
IS  - 4424
M3  - Article
SP  - 1309
EP  - 1311
SN  - 00368075
AB  - The structure and absolute stereoconfigurations off our adenosine adducts with (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of adenine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85195995; JEFFREY, A. M. 1; GRZESKOWIAK, K. 1; WEINSTEIN, I. B. 1; NAKANISHI, K. 1; ROLLER, P. 2; HARVEY, R. G. 3; Affiliations: 1: Cancer Center Institute of Cancer Research and Department of Chemistry, Columbia University, New York 10032; 2: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 3: Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637; Issue Info: 12/14/1979, Vol. 206 Issue 4424, p1309; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GADEK, JAMES E.
AU  - FELLS, GERALD A.
AU  - CRYSTAL, RONALD G.
T1  - Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans.
JO  - Science
JF  - Science
Y1  - 1979/12/14/
VL  - 206
IS  - 4424
M3  - Article
SP  - 1315
EP  - 1316
SN  - 00368075
AB  - Current concepts of the pathogenesis of emphysema suggest that it results from an imbalance of elastase and antielastase activity within the alveolar structures. Although emphysema that is associated with hereditary deficiency of serum α1-antitrypsin conforms to this scheme, the major risk factor in the more common form of emphysema is cigarette smoking. A study was designed to evaluate the premise that cigarette smoking may be associated with an acquired, functional defect in lung a,-antitrypsin. Determination of the antielastase activity of α1-antitrypsin obtained from the lungs of smoking and nonsmoking individuals revealed a nearly two fold reduction in the functional activity of this elastase inhibitor in the lungs of cigarette smokers. These data suggest that cigarette smokers may lose some of the normal antielastase protective screen of the lower respiratory tract, making them more vulnerable to destructive lung disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85195998; GADEK, JAMES E. 1; FELLS, GERALD A. 1; CRYSTAL, RONALD G. 1; Affiliations: 1: Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20205; Issue Info: 12/14/1979, Vol. 206 Issue 4424, p1315; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - CHAP
ID  - 2004-16199-002
AN  - 2004-16199-002
AU  - Gallagher, Dolores
AU  - Thompson, Larry W.
AU  - Levy, Sandra M.
ED  - Poon, Leonard W.
ED  - Poon, Leonard W., (Ed)
T1  - Clinical psychological assessment of older adults.
T2  - Aging in the 1980s: Psychological issues.
Y1  - 1980///
SP  - 19
EP  - 40
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 0-912704-15-2
N1  - Accession Number: 2004-16199-002. Partial author list: First Author & Affiliation: Gallagher, Dolores; Adult Counseling Center, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA, US. Release Date: 20040802. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-15-2, Paperback. Language: English. Major Descriptor: Gerontology; Psychological Assessment. Classification: Clinical Psychological Testing (2224); Gerontology (2860). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 22. 
AB  - Psychological assessment, as traditionally done, has not been adequate for obtaining a valid profile of older people's functional status. What is needed in the 1980s is evaluation of systematically obtained data from a number of substantive domains (e.g., physical health, coping skills, cognitive functioning, affective status) and careful integration of these data to formulate intervention programs. Current assessment procedures frequently used with the elderly are reviewed critically, and specific directions for future research are recommended. This chapter reviews problems, issues, and substantive areas related to clinical psychological assessment of the elderly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical psychological assessment
KW  - older adults
KW  - elderly
KW  - 1980
KW  - Gerontology
KW  - Psychological Assessment
KW  - 1980
DO  - 10.1037/10050-002
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2004-16199-003
AN  - 2004-16199-003
AU  - Levy, Sandra M.
AU  - Derogatis, Leonard R.
AU  - Gallagher, Dolores
AU  - Gatz, Margaret
ED  - Poon, Leonard W.
ED  - Poon, Leonard W., (Ed)
T1  - Intervention with older adults and the evaluation of outcome.
T2  - Aging in the 1980s: Psychological issues.
Y1  - 1980///
SP  - 41
EP  - 61
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 0-912704-15-2
N1  - Accession Number: 2004-16199-003. Partial author list: First Author & Affiliation: Levy, Sandra M.; National Cancer Institute, National Institutes of Health, Washington, DC, US. Release Date: 20040802. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-15-2, Paperback. Language: English. Major Descriptor: Biopsychosocial Approach; Disorders; Gerontology; Treatment Outcomes; Treatment. Minor Descriptor: Hospitalization; Outpatient Treatment. Classification: Psychological & Physical Disorders (3200); Gerontology (2860). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 21. 
AB  - Common forms of disorder found in older adults are discussed within a biopsychosocial framework, and interventions that seem to make a difference in quality of functioning are examined. Promising research directions for outpatient treatment include analysis of change mechanisms within cognitive intervention strategies and examination of essential parameters of outcome variables, such as time to criterion for successful therapeutic outcome. Research directions for inpatient treatment include examining commonalities across effective treatments, such as the enhancement of a sense of control, and a further examination of factors affecting person-environment fit. Questions concerning process and outcome research design, as well as methodology, are also considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - older adults
KW  - disorder
KW  - cognitive intervention strategies
KW  - therapeutic outcome
KW  - outpatient treatment
KW  - inpatient treatment
KW  - biopsychosocial framework
KW  - 1980
KW  - Biopsychosocial Approach
KW  - Disorders
KW  - Gerontology
KW  - Treatment Outcomes
KW  - Treatment
KW  - Hospitalization
KW  - Outpatient Treatment
KW  - 1980
DO  - 10.1037/10050-003
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2004-16199-018
AN  - 2004-16199-018
AU  - Giambra, Leonard M.
AU  - Arenberg, David
ED  - Poon, Leonard W.
ED  - Poon, Leonard W., (Ed)
T1  - Problem Solving, Concept Learning, and Aging.
T2  - Aging in the 1980s: Psychological issues.
Y1  - 1980///
SP  - 253
EP  - 259
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 0-912704-15-2
N1  - Accession Number: 2004-16199-018. Partial author list: First Author & Affiliation: Giambra, Leonard M.; Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, US. Release Date: 20040802. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-15-2, Paperback. Language: English. Major Descriptor: Aging; Concept Formation; Problem Solving. Classification: Cognitive & Perceptual Development (2820). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 7. 
AB  - Studies of problem solving and aging published since 1974 are briefly reviewed and are categorized according to the task studied: (a) concept learning, (b) problem solving other than concept learning, and (c) training to improve problem-solving performance. Some prescriptions for aging research in this area in the next decade include the following proposals: (a) to design aging studies within the framework of theories of problem solving that have been fruitful with young adults; (b) to avoid studying problems that have not been thoroughly investigated with young adults; (c) to adopt 'thinking-aloud' procedures; and (d) to study a small number of individuals over many problems. The goal of research in this next decade should be to predict individual performance as a function of age. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - problem solving
KW  - concept learning
KW  - aging
KW  - 1980
KW  - Aging
KW  - Concept Formation
KW  - Problem Solving
KW  - 1980
DO  - 10.1037/10050-018
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - GEN
AU  - Regazzi, John J
AU  - Bellicha, Terry
T1  - Alcohol information: some perspectives on the development of a problem-oriented system
JO  - Alcohol information: some perspectives on the development of a problem-oriented system
JF  - Alcohol information: some perspectives on the development of a problem-oriented system
Y1  - 1980///
M3  - Book
AB  - The development of the alcohol information retrieval system (airs) is discussed within the context of a problem-oriented information system. Characteristics of such an approach are described. The types of information which need to be assembled for the field of alcohol studies are also generally characterized. The function and the types of services provided by the automated data base are discussed, and a brief description of basis, the data management system presently used by airs, is also included.
N1  - Accession Number: ISTA1502836; Regazzi, John J 1; Bellicha, Terry 2; Affiliations: 1 : Center Of Alcohol Studies, Rutgers Univ., New Brunswick, Nj; 2 : Division of Prevention, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD;  Source Info: 1980; Note: Update Code: 1500; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Wagner, Edward H.
AU  - Slome, Cecil
AU  - Carroll, Carol L.
AU  - Warner, Jeanne T.
AU  - Pittman, A. Wayne
AU  - Pickard, C. Glenn
AU  - Williams, Benjamin O.
AU  - Cornoni-Huntley, Joan C.
T1  - Hypertension Control in a Rural Biracial Community: Successes and Failures of Primary Care.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/01//
VL  - 70
IS  - 1
M3  - Article
SP  - 48
EP  - 55
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Through a total community survey and a medical record review, we examined hypertension awareness, treatment, and control in a biracial rural community rich in primary care resources. The overall prevalence of hypertension among the 2,939 respondents was 20.5 per ¢; 82 per ¢ of hypertensives were aware of their condition: 68 per ¢ were on treatment; and 55 per ¢ were under control. Comparison of data sources revealed discrepancies and misconceptions about diagnosis and treatment. Nearly one-third of the population reported a history of hypertension despite the fact that most of them were untreated and were normotensive. Conversely. one-third of "undetected" hypertensives had notation of the diagnosis in their medical records. Discontinuation of treatment accounted for over one-half of aware but untreated hypertension. Misconceptions about therapy contributed to failures of control in the treated group. These findings suggest that difficulties in the transmission of information about hypertension contribute importantly to failures of control. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL surveys
KW  - MEDICAL records
KW  - HYPERTENSION
KW  - MEDICAL care
KW  - MEDICAL informatics
KW  - RURAL development
N1  - Accession Number: 4953718; Wagner, Edward H. 1 Slome, Cecil 1 Carroll, Carol L. 2 Warner, Jeanne T. 1,3 Pittman, A. Wayne 4 Pickard, C. Glenn 3 Williams, Benjamin O. 5 Cornoni-Huntley, Joan C. 6; Affiliation:  1: Department of Epidemiology, University of North Carolina School of Public Health, Rosenau HaIl 201 H. Chapel Hill, NC 27514.  2: Highway Safety Research Center, UNC.  3: Department of Medicine, UNC, School of Medicine.  4: School of Pharmacy, UNC.  5: Burroughs-Welcome Company.  6: National Institute on Aging, National Institutes of Health.; Source Info: Jan1980, Vol. 70 Issue 1, p48; Subject Term: SOCIAL surveys; Subject Term: MEDICAL records; Subject Term: HYPERTENSION; Subject Term: MEDICAL care; Subject Term: MEDICAL informatics; Subject Term: RURAL development; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Singer, Maxine
T1  - THE RECOMBINANT DNA DEBATE.
JO  - BioScience
JF  - BioScience
Y1  - 1980/01//
VL  - 30
IS  - 1
M3  - Book Review
SP  - 40
EP  - 40
SN  - 00063568
AB  - The article reviews the book "A Double Image of the Double Helix: The Recombinant DNA Debate," by Clifford Grobstein.
KW  - Recombinant DNA
KW  - Nonfiction
KW  - Grobstein, Clifford
KW  - Double Image of the Double Helix: The Recombinant DNA Debate, A (Book)
N1  - Accession Number: 28049428; Singer, Maxine 1; Affiliations: 1 : Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda,MD 20205;  Source Info: Jan1980, Vol. 30 Issue 1, p40; Subject Term: Recombinant DNA; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 453
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Trudgett, A.
AU  - Bellini, W. J.
AU  - Mingioli, E. S.
AU  - McFarlin, D. E.
T1  - Antibodies to the structural polypeptides of measles virus following acute infection and in SSPE.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/01//
VL  - 39
IS  - 1
M3  - Article
SP  - 652
EP  - 656
PB  - Wiley-Blackwell
SN  - 00099104
AB  - A solid-phase radioimmunoassay was used to determine the specificity of IgG antibodies from normal sera, sera and CSF from patients with SSPE for the structural polypeptides of measles virus. The polypeptide specificity of antibodies from these sources were qualitatively similar; these results indicate antigenic cross-reactivity between SSPE-derived (Mantooth) and non-SSPE-derived strains of measles virus and stimulation of antibody formation by comparable antigens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VIRUS diseases
KW  - PARAMYXOVIRUSES
KW  - MEASLES virus
KW  - IMMUNOGLOBULIN G
KW  - MEASLES
KW  - CANINE distemper virus
N1  - Accession Number: 17335387; Trudgett, A. 1 Bellini, W. J. 1 Mingioli, E. S. 1 McFarlin, D. E. 1; Affiliation:  1: Neuroimmunology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, USA.; Source Info: Jan1980, Vol. 39 Issue 1, p652; Subject Term: VIRUS diseases; Subject Term: PARAMYXOVIRUSES; Subject Term: MEASLES virus; Subject Term: IMMUNOGLOBULIN G; Subject Term: MEASLES; Subject Term: CANINE distemper virus; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donnelly, Edward F.
AU  - Murphy, Dennis L.
AU  - Waldman, Ivan N.
T1  - DENIAL AND SOMATIZATION AS CHARACTERISTICS OF BIPOLAR DEPRESSED GROUPS.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1980/01//
VL  - 36
IS  - 1
M3  - Article
SP  - 159
EP  - 162
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article reports on denial and somatization as characteristics of bipolar depressed groups. In recent years, a number of studies that used clinical self-report tests have suggested that bipolar depressed groups generally report less overall psychopathology than unipolar groups. Studies of bipolar depressed groups with the Minnesota Multiphasic Personality Inventory (MMPI) consistently have shown lower scores on most clinical scales than unipolar groups, but these group differences mostly disappeared during the recovery period. To account for the differential effect in self-reported psychopathology between groups, it has been suggested that relatively high MMPI scores in the unipolar group are associated with socially undesirable response sets.
KW  - SOMATIZATION disorder
KW  - PATHOLOGICAL psychology
KW  - DEPRESSED persons
KW  - GROUPS
KW  - MENTALLY ill
KW  - PSYCHOTHERAPY
N1  - Accession Number: 15934160; Donnelly, Edward F. 1 Murphy, Dennis L. 2 Waldman, Ivan N. 1; Affiliation:  1: National Institute of Mental Health, St. Elizabeths Hospital, Washington, D. C.  2: National Institute of Mental Health, Bethesda, Maryland.; Source Info: Jan1980, Vol. 36 Issue 1, p159; Subject Term: SOMATIZATION disorder; Subject Term: PATHOLOGICAL psychology; Subject Term: DEPRESSED persons; Subject Term: GROUPS; Subject Term: MENTALLY ill; Subject Term: PSYCHOTHERAPY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lawley, T. J.
AU  - Strober, W.
AU  - Yaoita, H.
AU  - Katz, S. I.
T1  - Small Intestinal Biopsies and HLA Types in Dermatitis Herpetiformis Patients with Granular and Linear IgA Skin Deposits.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/01//
VL  - 74
IS  - 1
M3  - Article
SP  - 9
EP  - 12
SN  - 0022202X
AB  - In this study we determined whether dermatitis herpetiformis patients whose skin contained linear IgA deposits differ from those whose skin contained granular IgA deposits with regard to the presence of gluten-sensitive enteropathy and with regard to the prevalence of certain histocompatibility antigens. We performed multiple Rubin tube intestinal biopsies on 11 patients, 6 with linear and 5 with granular IgA deposits. The gut biopsies were evaluated histopathologically in a blinded fashion. We found that none of the patients with linear deposits (5 with lamina lucida and 1 with sub-basal lamina deposits) had detectable jejunal abnormalities whereas all of those with granular deposits had jejunal abnormalities (villous atrophy and increased numbers of intraepithelial lymphocytes). In parallel studies HLA typing was performed in 10 patients with linear IgA deposits and in 49 patients with granular deposits. Only 30% of those with linear deposits had HLA-B8, a prevalence not significantly different from that of the normal population (24%); in contrast, 88% of those with granular deposits had HLA-B8, a prevalence significantly greater than in the normal population (<em>p</em> < 0.001). We therefore conclude that patients with linear IgA deposits have a disease which is pathophysiologically different from those with granular IgA deposits. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DERMATITIS herpetiformis
KW  - IMMUNOGLOBULIN A
KW  - HISTOCOMPATIBILITY antigens
KW  - INTESTINAL diseases
KW  - BIOPSY
KW  - SKIN diseases
N1  - Accession Number: 12514565; Lawley, T. J. Strober, W. 1 Yaoita, H. Katz, S. I.; Affiliation:  1: Dermatology and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1980, Vol. 74 Issue 1, p9; Subject Term: DERMATITIS herpetiformis; Subject Term: IMMUNOGLOBULIN A; Subject Term: HISTOCOMPATIBILITY antigens; Subject Term: INTESTINAL diseases; Subject Term: BIOPSY; Subject Term: SKIN diseases; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12514565
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Foidart, Jean-Michel
AU  - Murray, J. Clifford
AU  - Martin, George R.
AU  - Katz, Stephen I.
T1  - The Epidermal Cell which Selectively Adheres to a Collagen Substrate is the Basal Cell.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/01//
VL  - 74
IS  - 1
M3  - Article
SP  - 54
EP  - 58
SN  - 0022202X
AB  - In order to determine whether a specific subpopulation of epidermal cells selectively attaches to collagen substrates <em>in vitro</em>, epidermal cell suspensions, obtained by trypsinization of guinea pig skin, were incubated on type I or type IV collagen-coated glass cover slips. It was noted, morphologically and by electronic volume measurements, that small round cells, as opposed to the larger angulated flat cells, adhered to the collagen substrates. To further characterize the attached cells, the percentage of basal cells was determined in the attached cell population and in the initial epidermal cell suspension. Basal cells were identified by indirect immunofluorescence in 2 ways: (1) by the presence of pemphigoid antigen and (2) by the absence of upper cytoplasmic antigen, which is present in all keratinocytes except the basal cells. Whereas in the initial guinea pig epidermal cell suspensions about 50% of the cells were basal cells using either of these 2 criteria, 86-97% of the cells which adhered to the collagen substrates were basal cells. Human basal cells, as defined by pemphigoid antigen, also selectively adhered to the collagen substrates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - COLLAGEN
KW  - GUINEA pigs
KW  - EPIDERMIS
KW  - IMMUNOFLUORESCENCE
KW  - CELL proliferation
N1  - Accession Number: 12514618; Stanley, John R. 1 Foidart, Jean-Michel 2 Murray, J. Clifford 2 Martin, George R. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch of the National Cancer Institute, National Institutes of Health,  Bethesda, Maryland, U.S.A.  2: Laboratory of Developmental Biology and Anomalies of the National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1980, Vol. 74 Issue 1, p54; Subject Term: SKIN; Subject Term: COLLAGEN; Subject Term: GUINEA pigs; Subject Term: EPIDERMIS; Subject Term: IMMUNOFLUORESCENCE; Subject Term: CELL proliferation; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12514618
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2009-11732-001
AN  - 2009-11732-001
AU  - Mosher, Loren R.
AU  - Meltzer, Herbert Y.
T1  - Drugs and psychosocial treatment: Editors’ introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1980///
VL  - 6
IS  - 1
SP  - 8
EP  - 9
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Mosher, Loren R., CSS, CRB, NIMH, 5600 Fishers Lane, Rm. 10-95, Rockville, MD, US, 20857
N1  - Accession Number: 2009-11732-001. PMID: 6102796 Partial author list: First Author & Affiliation: Mosher, Loren R.; Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Psychotherapy; Schizophrenia; Adjunctive Treatment. Minor Descriptor: Drug Therapy; Neuroleptic Drugs. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: 1980. 
AB  - The role of psychosocial approaches to the care and treatment of some forms of psychosis, particularly schizophrenia, has been overshadowed in the minds of some clinicians and investigators by the establishment of the efficacy of the major tranquilizers in the treatment of these conditions. During the past two decades, there has been a tendency to conceive of neuroleptic treatment as the only proven form of treatment for psychosis. Fortunately new evidence has begun to accumulate, albeit not of the same rigor of design and analysis associated with clinical psychopharmacology, that psychosocial approaches are not only useful but have different effects on outcome in schizophrenia than neuroleptics have, and thus can complement their use. As emphasized in three of the articles in this issue (Mosher and Keith, Gunderson, and Wallace et al.), the comprehensiveness of the psychosocial treatment program and the availability of a social network to reinforce, maintain, and support the gains achieved by more formal treatment programs, of which psychopharmacology may be an essential element, appear to be critical. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - psychosocial treatment
KW  - psychotherapy
KW  - neuroleptic drugs
KW  - drug therapy
KW  - adjunctive treatment
KW  - 1980
KW  - Psychotherapy
KW  - Schizophrenia
KW  - Adjunctive Treatment
KW  - Drug Therapy
KW  - Neuroleptic Drugs
KW  - 1980
DO  - 10.1093/schbul/6.1.8
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42175-018
AN  - 2013-42175-018
AU  - Shore, Milton F.
T1  - Review of Violent delinquents and The psychological world of the juvenile delinquent.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1980/01//
VL  - 50
IS  - 1
SP  - 169
EP  - 171
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42175-018. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Juvenile Delinquency; Male Delinquency; Sociocultural Factors. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10). Reviewed Item: Strasburg, Paul A. Violent delinquents=272 pp. $16.95. Sovereign Books, New York; 1978. Offer, Daniel; Marohn, Richard C.; Ostrov, Eric. The psychological world of the juvenile delinquent=224 pp. $15.00. Basic Books, New York; 1979. Page Count: 3. Issue Publication Date: Jan, 1980. 
AB  - Reviews the books, Violent Delinquents by Paul A. Strasburg (see record [rid]1980-50594-000[/rid]) and The Psychological World of the Juvenile Delinquent by Daniel Offer, Richard C. Marohn, and Eric Ostrov (1979). Both volumes, although courageous in trying to deal with one of the most difficult and frustrating groups of juvenile delinquents, seem to be of limited value. Both plead for programs, but do not adequately describe such programs or show how they can be implemented. Both focus around treatment and do not in any way look back to find out how the difficulties could have been prevented or identified earlier. Both give us limited understanding theoretically, and offer little new knowledge. Both tend to ignore or only casually refer to the family, the group, the community, the cultural milieu, and the social dynamics of delinquent behavior. Both seem symptomatic of how stuck we are in continuing our narrow preoccupations with either psychiatric or systems models, rather than using new frameworks- such as ecology, with wide-ranging community-based intervention techniques incorporating elements such as outreach, family work, special schooling, or employment- and integrating the knowledge we have to produce imaginative, carefully planned, well executed, and creatively evaluated programs aimed at preventing as well as treating the violent juvenile. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cultural milieu
KW  - juvenile delinquents
KW  - social dynamics
KW  - violent juvenile
KW  - community-based intervention
KW  - 1980
KW  - Juvenile Delinquency
KW  - Male Delinquency
KW  - Sociocultural Factors
KW  - 1980
U2  - Strasburg, Paul A. (1978); Violent delinquents; 272 pp. $16.95. Sovereign Books, New York
U2  - Offer, Daniel; Marohn, Richard C.; Ostrov, Eric. (1979); The psychological world of the juvenile delinquent; 224 pp. $15.00. Basic Books, New York
DO  - 10.1111/j.1939-0025.1980.tb03275.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - RAPOPORT, S. I.
AU  - KLEE, W. A.
AU  - PETTIGREW, K. D.
AU  - OHNO, K.
T1  - Entry of Opioid Peptides into the Central Nervous System.
JO  - Science
JF  - Science
Y1  - 1980/01/04/
VL  - 207
IS  - 4426
M3  - Article
SP  - 84
EP  - 86
SN  - 00368075
AB  - Cerebrovascular permeability of four modified opioid peptides-[DAla²] methionine enkephalin amide, β-[D-Ala62,"14C-Homoarg69]lipotropin 61-69, α- [D-Ala²,'14C-Homoarg9]endorphin, and β-[u-Ala², 14C-Homoarg]endorphin -ranged from 1.4 to 3.9 x 10-6 centimeters per second in brain regions of the conscious rat. These significant permeabilities should allow the peptides to fill the extracellular brain space with a half time of 3 to 11 minutes, as a result of a step increase in plasma concentration of unbound peptide [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269368; RAPOPORT, S. I. 1; KLEE, W. A. 2; PETTIGREW, K. D. 3; OHNO, K. 4; Affiliations: 1: Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, Maryland 21224; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland; 3: Theoretical Statistics and Mathematics Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center; Issue Info: 1/ 4/1980, Vol. 207 Issue 4426, p84; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WYATT, RICHARD G.
AU  - JAMES, WALTER D.
AU  - BOHL, EDWARD H.
AU  - THEIL, KENNETH W.
AU  - SAIF, LINDA J.
AU  - KALICA, ANTHONY R.
AU  - GREENBERG, HARRY B.
AU  - KAPIKIAN, ALBERT Z.
AU  - CHANOCK, ROBERT M.
T1  - Human Rotavirus Type 2: Cultivation in vitro.
JO  - Science
JF  - Science
Y1  - 1980/01/11/
VL  - 207
IS  - 4427
M3  - Article
SP  - 189
EP  - 191
SN  - 00368075
AB  - A strain of type 2 human rotavirus (Wa) was grown to relatively high titer through 14 passages in primary cultures of African green monkey kidney (AGMK) cells. This passage series was initiated with virus that had been passaged 11 times serially in newborn gnotobiotic piglets. In contrast, virus present in the stool of patient Wa as well as virus from the first, second, or third passage in piglets could not be propagated successfully in African green monkey kidney cells. Prior to each passage in cell culture, the virus was treated with trypsin and the inoculated cultures were centrifuged at low speed. Cultivation of a type 2 human rotavirus should aid attempts to characterize this virus and to develop a means of immunoprophylaxis for a serious diarrheal disease of human infants. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269401; WYATT, RICHARD G. 1; JAMES, WALTER D. 1; BOHL, EDWARD H. 2; THEIL, KENNETH W. 2; SAIF, LINDA J. 2; KALICA, ANTHONY R. 3; GREENBERG, HARRY B. 3; KAPIKIAN, ALBERT Z. 3; CHANOCK, ROBERT M. 3; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Ohio Agricultural Research and Development Center, Wooster 44691; 3: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 1/11/1980, Vol. 207 Issue 4427, p189; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HUANG, LI-YEN MAE
AU  - BARKER, JEFFERY L.
T1  - Pentobarbital: Stereospecific Actions of (+) and (-) Isomers Revealed on Cultured Mammalian Neurons.
JO  - Science
JF  - Science
Y1  - 1980/01/11/
VL  - 207
IS  - 4427
M3  - Article
SP  - 195
EP  - 197
SN  - 00368075
AB  - Stereoisomers of the barbiturate anesthetic pentobarbital were applied to mouse spinal neurons growing in tissue culture. Intracellular recordings of neuronal membrane properties revealed that the (+) and (-) isomers caused direct changes in membrane potential and conductance on some but not all of the cells tested. The action of the (+) isomer was predominantly excitatory, whereas the (-) isomer produced predominantly inhibitory responses. The (-) isomer was considerably more effective in potentiating inhibitory responses to the transmitter gammaaminobutyric acid. The results show that pentobarbital has multiple effects on neuronal excitability and demonstrate the presence of stereospecific sites of barbiturate action on central neurons. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85269404; HUANG, LI-YEN MAE 1; BARKER, JEFFERY L. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/11/1980, Vol. 207 Issue 4427, p195; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Chepelinsky, Ana Berta
AU  - Gantt, Raymond
AU  - Wivel, Nelson
T1  - Presence of RNA Methylases in Intracisternal A Particles Purified from a Mouse Plasma Cell Tumor.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/01/15/
VL  - 103
IS  - 2
M3  - Article
SP  - 339
EP  - 347
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Intracisternal A particles share several biochemical properties with RNA tumor viruses, including 70-S RNA, reverse transcriptase, and a group-specific protein. In addition they form by budding from cytoplasmic membranes. It has been shown previously that various purified RNA tumor viruses contain N2-guanine RNA methylase; purified A particles were tested to determine if they contained this activity as well. The results showed that instead of a single methylase, six methylases were associated with intracisternal A particles: a cytidine and a uridine methylase, two N2-guanine monomethylases, an N2,N2-dimethylguanine methylase and an adenine methylase. These enzymes were indistinguishable from the cellular enzymes when Escherichia coli tRNAPhe was used as an acceptor RNA and three were shown to have the identical specificity, i.e. N2-guanine methylases for positions 10 and 34 and methylation of adenine in position 73 of the tRNAPhe. The specific activity of the core-associated RNA methylases increased approximately twofold over the methylases of the intact particles, indicating that these methylases were associated with the internal structure and not simply adherent to the envelope surface. This suggests that these cellular enzymes are packaged within intracisternal A particles during synthesis. Thus, intracisternal A particles are similar to the oncornaviruses in that reverse transcriptase is the only known enzyme not of cellular origin, but they appear to contain cellular methylases not found in other RNA tumor viruses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ONCOGENIC viruses
KW  - RNA
KW  - PROTEINS
KW  - CELL membranes
KW  - ENZYMES
KW  - METHYLTRANSFERASES
N1  - Accession Number: 13602758; Chepelinsky, Ana Berta 1 Gantt, Raymond 1 Wivel, Nelson 1; Affiliation:  1: Laboratory of Cellular and Molecular Biology and Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda; Source Info: 1/15/80, Vol. 103 Issue 2, p339; Subject Term: ONCOGENIC viruses; Subject Term: RNA; Subject Term: PROTEINS; Subject Term: CELL membranes; Subject Term: ENZYMES; Subject Term: METHYLTRANSFERASES; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moses, Alan C.
AU  - Nissley, S. Peter
AU  - Short, Patricia A.
AU  - Rechler, Matthew M.
AU  - Podskalny, Judy M.
T1  - Purification and Characterization of Multiplication-Stimulating Activity.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/01/15/
VL  - 103
IS  - 2
M3  - Article
SP  - 387
EP  - 400
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Multiplication-stimulating activity (MSA) refers to a family of insulin-like growth factors that have been purified from serum-free medium conditioned by a Buffalo rat liver cell line (BRL-3A). Using Dowex ion-exchange chromatography, gel chromatography on Sephadex G-75, and preparative disc acrylamide gel electrophoresis, several polypeptides with the full biological multiplication- stimulating activity have been isolated. One of these polypeptides, designated MSA II-1, previously has been used to study the relationship of the activity to the insulin-like growth factors (somatomedins) purified from human plasma. Polypeptide II-1 is a single chain polypeptide of molecular weight 8700. Glycine is the COOH-terminal amino acid. Edman degradation of carboxymethylated MSA II-1 did not reveal a free NH2-terminus. A polypeptide of lower molecular weight than MSA II-1 has also been purified. This polypeptide (MSA III-2) has been shown to be more potent than MSA II-1 in the rat-liver-membrane radioreceptor assay and in a competitive binding assay utilizing the rat-serum somatomedin-binding protein(s). The relationship of these various poly-peptides has been investigated by gel filtration in guanidine hydrochloride and by acrylamide gel electrophoresis of the reduced and native polypeptides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GROWTH factors
KW  - INSULIN
KW  - LIVER cells
KW  - CELL lines
KW  - ION exchange chromatography
KW  - PEPTIDES
KW  - CARRIER proteins
N1  - Accession Number: 13602864; Moses, Alan C. 1 Nissley, S. Peter 1 Short, Patricia A. 1 Rechler, Matthew M. 1 Podskalny, Judy M. 1; Affiliation:  1: Endocrine Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, and Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 1/15/80, Vol. 103 Issue 2, p387; Subject Term: GROWTH factors; Subject Term: INSULIN; Subject Term: LIVER cells; Subject Term: CELL lines; Subject Term: ION exchange chromatography; Subject Term: PEPTIDES; Subject Term: CARRIER proteins; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moses, Alan C.
AU  - Nissley, S. Peter
AU  - Short, Patricia A.
AU  - Rechler, Matthew M.
T1  - Immunological Cross-reactivity of Multiplication-Stimulating Activity Polypeptides.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/01/15/
VL  - 103
IS  - 2
M3  - Article
SP  - 401
EP  - 408
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The immunoreactivity of the multiple species of multiplication-stimulating activity (MSA) purified from medium conditioned by a rat liver cell line (BRL-3A) has been examined. Antibodies were raised in rabbits following immunization with MSA II polypeptides. Subpopulations of anti- bodies were purified from one antiserum using DEAE-cellulose chromatography. One antibody subpopulation recognized common antigenic determinants on MSA I and MSA II polypeptides; whereas a second antibody subpopulation recognized common determinants on MSA I, II, and III polypeptides. In a radioimmunoassay utilizing 125I-MSA III-2 and a purified antibody subpopulation, the human somatomedins (somatomedin A, insulin-like growth factor I and II) showed weak, but significant cross-reactivity: insulin-like growth factor II was 10% as potent as MSA II. By contrast, somatomedin partially purified from rat serum, insulin, growth hormone, epidermal growth factor, nerve growth factor, and fibroblast growth factor, showed no reactivity in the radio-immunoassay. [ABSTRACT FROM AUTHOR]
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KW  - LIVER cells
KW  - CELL lines
KW  - IMMUNOGLOBULINS
KW  - PEPTIDES
KW  - GROWTH factors
KW  - INSULIN
N1  - Accession Number: 13602877; Moses, Alan C. 1 Nissley, S. Peter 1 Short, Patricia A. 1 Rechler, Matthew M. 1; Affiliation:  1: Endocrine Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland,a nd Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institute of Health, Bethesda, Maryland; Source Info: 1/15/80, Vol. 103 Issue 2, p401; Subject Term: LIVER cells; Subject Term: CELL lines; Subject Term: IMMUNOGLOBULINS; Subject Term: PEPTIDES; Subject Term: GROWTH factors; Subject Term: INSULIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Tallman, John F.
AU  - Paul, Steven M.
AU  - Skolnick, Phil
AU  - Gallager, Dorothy W.
T1  - Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines.
JO  - Science
JF  - Science
Y1  - 1980/01/18/
VL  - 207
IS  - 4428
M3  - Article
SP  - 274
EP  - 281
SN  - 00368075
N1  - Accession Number: 85266201; Tallman, John F. 1; Paul, Steven M. 2; Skolnick, Phil 3; Gallager, Dorothy W. 1; Affiliations: 1: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Clinical Psychobiology Branch, National Institute of Mental Health; 3: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, Bethesda, Maryland 20205; Issue Info: 1/18/1980, Vol. 207 Issue 4428, p274; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MCCULLOCH, JAMES
AU  - SAVAKI, HELEN E.
AU  - MCCULLOCH, MAILIS C.
AU  - SOKOLOFF, LOUIS
T1  - Retina-Dependent Activation by Apomorphine of Metabolic Activity in the Superficial Layer of the Superior Colliculus.
JO  - Science
JF  - Science
Y1  - 1980/01/18/
VL  - 207
IS  - 4428
M3  - Article
SP  - 313
EP  - 315
SN  - 00368075
AB  - Studies of the effects of the dopamine agonist apomorphine on local cerebral glucose utilization by means of the carbon-14-labeled deoxyglucose method demonstrate a dose-dependent metabolic activation in the superficial layer of the superior colliculus in the rat. Apomorphine stimulated glucose utilization in a number of other cerebral structures, but only the effect in the superficial layer of the superior colliculus depended on an intact retinal input. This effect was present with the animal in the light or in the dark, but was abolished by enucleation, which left the effects in other cerebral structures unimpaired. Activation of the superficial layer of the superior colliculus appears, therefore, to be secondary to an action of apomorphine on dopaminergic systems within the retina. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266224; MCCULLOCH, JAMES 1; SAVAKI, HELEN E. 1; MCCULLOCH, MAILIS C. 1; SOKOLOFF, LOUIS 1; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 1/18/1980, Vol. 207 Issue 4428, p313; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LAKE, C. R.
AU  - STERNBERG, D. E.
AU  - VAN KAMMEN, D. P.
AU  - BALLENGER, J. C.
AU  - ZIEGLER, M. G.
AU  - POST, R. M.
AU  - KOPIN, I. J.
AU  - BUNNEY, W. E.
T1  - Schizophrenia: Elevated Cerebrospinal Fluid Norepinephrine.
JO  - Science
JF  - Science
Y1  - 1980/01/18/
VL  - 207
IS  - 4428
M3  - Article
SP  - 331
EP  - 333
SN  - 00368075
AB  - Concentrations of norepinephrine in cerebrospinal fluid are higher in schizophrenic patients, particularly in those with paranoid features, than in normal volunteer subjects of the same age. This observation supports recent reports of elevated concentrations of norepinephrine in specific brain areas adjacent to the cerebral ventricles of paranoid schizophrenic patients. Overflow of the amine from periventricular regions into the cerebrospinal fluid may reflect abnormally high release or diminished enzymatic destruction of norepinephrine in patients with schizophrenia. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266233; LAKE, C. R. 1; STERNBERG, D. E. 2; VAN KAMMEN, D. P. 2; BALLENGER, J. C. 2; ZIEGLER, M. G. 3; POST, R. M. 2; KOPIN, I. J. 3; BUNNEY, W. E. 3; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Biological Psychiatry Branch, National Institute of Mental Health; 3: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 1/18/1980, Vol. 207 Issue 4428, p331; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Magnuson, R A
T1  - Project rmag: slang (structured language) compiler
JO  - Rep. No: NIH-DCRT-DMB-SSS-UG105-80
JF  - Rep. No: NIH-DCRT-DMB-SSS-UG105-80
Y1  - 1980/01/24/
M3  - Book Chapter
AB  - Sporting its new name, this is the long-promised rmagasm in rmagasm. Designed to assist programmers writing powerful structured programs, the slang compiler generates block-structured ibm 370 assembly language source code. Based on some six years experience developing and using the rmag--implemented rmagasm compiler, slang retains the important features of its predecessor while adding some original, new ones of its own
N1  - Accession Number: ISTA1700615; Magnuson, R A 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Md. Div. Of Computer Research And Technology;  Source Info: Jan. 24, 1980; Note: Update Code: 1700; Number of Pages: 150p; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - HAGINS, W. A.
T1  - Near-Infrared Microscopy.
JO  - Science
JF  - Science
Y1  - 1980/01/25/
VL  - 207
IS  - 4429
M3  - Article
SP  - 358
EP  - 358
SN  - 00368075
N1  - Accession Number: 85266235; HAGINS, W. A. 1; Affiliations: 1: Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/25/1980, Vol. 207 Issue 4429, following p358; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Brownstein, Michael J.
AU  - Russell, James T.
AU  - Gainer, Harold
T1  - Synthesis, Transport, and Release of Posterior Pituitary Hormones.
JO  - Science
JF  - Science
Y1  - 1980/01/25/
VL  - 207
IS  - 4429
M3  - Article
SP  - 373
EP  - 378
SN  - 00368075
N1  - Accession Number: 85266239; Brownstein, Michael J. 1; Russell, James T. 2; Gainer, Harold 2; Affiliations: 1: Member of the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Members of the Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda; Issue Info: 1/25/1980, Vol. 207 Issue 4429, p373; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Haynes, Suzanne G.
AU  - Feinleib, Manning
T1  - Women, Work and Coronary Heart Disease: Prospective Findings from the Framingham Heart Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/02//
VL  - 70
IS  - 2
M3  - Article
SP  - 133
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: This study examined the relationship of employment status and employment-related behaviors to the incidence of corona,'y heart disease (CHD) in women. Between 1965 and 1967. a psychosocial questionnaire was administered to 350 housewives. 387 working women (women who had been employed outside the home over one-half their adult years), and 580 men participating in the Framingham Heart Study, The respondents were 45 to 64 years of age and were followed for the development of CHD over the ensuing eight years. Regardless of employment status, women reported signiticantly more symptoms of emotional distress than men. Working women and men were more likely to report Type A behavior, ambitiousness. and marital disagreements than were housewives: working women experienced more job mobility than men. and more daily stress and marital dissatisfaction than housewives or men. Working women did not have significantly higher incidence rates of CHD than housewives 17.8 vs 5.4 per ¢. respectively). However. CHD rates were it[most twice as great among women homing clerical jobs (10.6 per ¢) as compared to housewives. The most significant predictors of CHD among clerical workers were: suppressed hostility. having a nonsupportive boss. and decreased job mobility CHD rates were higher among working women who had ever married, especially among those who had raised three or more children. Among working women electrical workers who had children and were married blue collar workers were at highest risk of developing CHD [21.3 per ¢.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WOMEN employees
KW  - HEART diseases in women
KW  - CORONARY heart disease
KW  - STRESS (Psychology)
KW  - WOMEN -- Diseases
KW  - WOMEN'S health services
KW  - BLUE collar workers
KW  - OCCUPATIONAL mobility
KW  - RESEARCH
N1  - Accession Number: 4958499; Haynes, Suzanne G. 1 Feinleib, Manning 2; Affiliation:  1: Epidemiology Branch, National heart, Lung and Blood Institute, Federal Building, Room 2C08, Bethesda, MD 20205.  2: Associate Director, Epidemiology and Biometry Program, NHLBI.; Source Info: Feb1980, Vol. 70 Issue 2, p133; Subject Term: WOMEN employees; Subject Term: HEART diseases in women; Subject Term: CORONARY heart disease; Subject Term: STRESS (Psychology); Subject Term: WOMEN -- Diseases; Subject Term: WOMEN'S health services; Subject Term: BLUE collar workers; Subject Term: OCCUPATIONAL mobility; Subject Term: RESEARCH; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Agbata, A. I.
AU  - Kirkpatrick, B. H.
T1  - Circulating immune complexes containing anti-VIII antibodies in multi-transfused patients with haemophilia A.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/02//
VL  - 39
IS  - 2
M3  - Article
SP  - 315
EP  - 320
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Evidence for the presence of circulating immune complexes was found in thirty-four out of fifty-five samples from forty-seven patients with haemophila A. In eleven patients the complexes, precipitated from the blood with polyethylene glycol, were digested with pepsin. The F(ab')2 antibody was tested, and found to have neutralizing activity against coagulant Factor VIII in two patients. In one of these no free antibody had ever been found in the plasma, while in the other the antibody was concentrated tenfold in the complex. In two other samples free without complexed antibody was found. In comparison, IgG-containing complexes were found in nine out of nineteen patients with von Wiliebrand's disease and no complexes were found in the sera from twelve multi-transfused thalassaemics. PEG precipitation is a useful technique for the preparation of concentrated immune complexes for further study such as antigen identification. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE complexes
KW  - HAEMOPHILUS
KW  - POLYETHYLENE glycol
KW  - PEPSIN
KW  - IMMUNOGLOBULINS
KW  - COAGULATION
KW  - ANTIGENS
N1  - Accession Number: 15960828; Agbata, A. I. 1 Kirkpatrick, B. H. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Feb1980, Vol. 39 Issue 2, p315; Subject Term: IMMUNE complexes; Subject Term: HAEMOPHILUS; Subject Term: POLYETHYLENE glycol; Subject Term: PEPSIN; Subject Term: IMMUNOGLOBULINS; Subject Term: COAGULATION; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fisher, R. I.
AU  - Mandell, G. L.
AU  - Bostick, Frieda
AU  - Mcmenamin, Mary G.
AU  - Anderson, T.
T1  - Chlorozotocin, an anti-tumour agent lacking bone marrow toxicity at therapeutic doses: effects on lymphocyte subpopulations in mice.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/02//
VL  - 39
IS  - 2
M3  - Article
SP  - 416
EP  - 425
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Chlorozotocin is a new nitrosourea anti-tumour drug that does not produce bone marrow suppression at therapeutic doses in mice. CDF1 mice which were injected i.p. with a dose lethal to 10% of animals within W days (LD10), 20 mg/kg, developed a 50% reduction in circulating peripheral blood lymphocytes without a decrease in circulating granulocytes by day 3. Spleen weight also decreased markedly. The percentage of spleen B and T cells, determined by immunofluorescence with goat anti-mouse IgG and rabbit anti-mouse brain antisera, did not differ in control and chlorozotocin-treated mice. However, the ability of residual spleen cells to proliferate in response to phytohaemagglutinin, concanavalin A, pokeweed mitogen, and allogeneic cells was significantly .suppressed although the lipopolysaccharide response was not reduced. The ability of the mice to respond to a primary immunization with sheep red blood cells was not significantly impaired. Therefore, chlorozotocin has a cytotoxic effect on both B and T cells but selectively inhibits the proliferative capacity of T cells. B cell proliferation and Ii cell function as measured in a primary antibody response were not reduced. These studies suggest chlorozotocin may be useful as an immunosuppressive drug as well as an anti-tumour agent. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NITROSOUREAS
KW  - BONE marrow
KW  - TOXICITY testing
KW  - LYMPHOCYTES
KW  - IMMUNOFLUORESCENCE
KW  - GRANULOCYTES
KW  - T cells
KW  - MITOGENS
N1  - Accession Number: 15960865; Fisher, R. I. 1 Mandell, G. L. 1 Bostick, Frieda 1 Mcmenamin, Mary G. 1 Anderson, T. 1; Affiliation:  1: Medicine Branch, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Feb1980, Vol. 39 Issue 2, p416; Subject Term: NITROSOUREAS; Subject Term: BONE marrow; Subject Term: TOXICITY testing; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOFLUORESCENCE; Subject Term: GRANULOCYTES; Subject Term: T cells; Subject Term: MITOGENS; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HERKENHAM, MILES
T1  - Laminar Organization of Thalamic Projections to the Rat Neocortex.
JO  - Science
JF  - Science
Y1  - 1980/02//2/ 1/1980
VL  - 207
IS  - 4430
M3  - Article
SP  - 532
EP  - 535
SN  - 00368075
AB  - Nervefibers transmitting information from the thalamus to the cerebral cortex may be classified according to their major cortical layers of termination. (i) One class consists of inputs from thalamic relay nuclei for vision, audition, and somesthesis to layer IV, layer III, or both. In contrast, autoradiographic studies of projections from other thalamic nuclei reveal strikingly different patterns of termination: (ii) layer VI (or layer V, or both) is the target of fibers from the intralaminar nuclei, and (iii) layer I is the target forfibers from the ventromedial and magnocellular medial geniculate nuclei. (iv) The remaining class is typified by termination both in layer I and in additional layers that depend on the cortical area in which the terminations are found. The data demonstrate that convergent thalamic inputs to a given cortical area are usually not confluent within a layer and provide a newframework for categorizing thalamic nuclei. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266303; HERKENHAM, MILES 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 2/ 1/1980, Vol. 207 Issue 4430, p532; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2011-08324-007
AN  - 2011-08324-007
AU  - Silberman, Edward K.
AU  - Post, Robert M.
T1  - The march of symptoms in a psychotic decompensation: Case report and theoretical implications.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1980/02//
VL  - 168
IS  - 2
SP  - 104
EP  - 110
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Post, Robert M., Section on Psychobiology, National Institute of Mental Health, Building 10, Room 3S239, 9000 Rockville Pike, Bethesda, MD, US, 20205
N1  - Accession Number: 2011-08324-007. PMID: 7354306 Partial author list: First Author & Affiliation: Silberman, Edward K.; Section on Psychobiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110711. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Disease Course; Epilepsy; Major Depression; Psychosis; Symptoms. Minor Descriptor: Kindling; Seizures. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Tests & Measures: Bunney-Hamburg Scale-Modified version. Methodology: Clinical Case Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb, 1980. Copyright Statement: The Williams & Wilkins Co. 1980. 
AB  - The onset and evolution of symptoms were studied in a female patient with a history of recurrent depressive psychoses. In each episode, her psychotic decompensations were characterized by an orderly and progressive sequence including similar psychological or somatic precipitants, mounting anxiety, nystagmoid eye movements associated with panic, unfolding delusions, and olfactory hallucinations, culminating in a complete psychotic regression. The evolving sequence repeated during each episode in the present case is compared with that of a similarly stereotyped progression of symptoms in temporal lobe and Jacksonian seizures. Kindling is suggested as a model relevant to the understanding of both epilepsy and the functional psychoses. Detailed observation of the evolution of symptoms during psychotic episodes may provide important clues to the underlying pathological anatomy and physiology of psychotic illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - recurrent depressive psychosis
KW  - psychotic decompensation
KW  - disease course
KW  - symptom progression
KW  - temporal lobe & Jacksonian seizures
KW  - epilepsy
KW  - kindling
KW  - 1980
KW  - Disease Course
KW  - Epilepsy
KW  - Major Depression
KW  - Psychosis
KW  - Symptoms
KW  - Kindling
KW  - Seizures
KW  - 1980
DO  - 10.1097/00005053-198002000-00007
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08324-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - PARLOFF, MORRIS B.
T1  - Appraising Psychotherapy.
JO  - Science
JF  - Science
Y1  - 1980/02/22/
VL  - 207
IS  - 4433
M3  - Article
SP  - 823
EP  - 823
SN  - 00368075
N1  - Accession Number: 85361610; PARLOFF, MORRIS B. 1; Affiliations: 1: Psychotherapy and Behavioral Intervention Section, Clinical Research Branch, National Institute of Mental Health, Rockville, Maryland 20857; Issue Info: 2/22/1980, Vol. 207 Issue 4433, p823; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pickle, Linda W.
AU  - Gottlieb, Marise S.
T1  - Pancreatic Cancer Mortality in Louisiana.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/03//
VL  - 70
IS  - 3
M3  - Article
SP  - 256
EP  - 259
PB  - American Public Health Association
SN  - 00900036
AB  - As a preliminary step in the investigation of high pancreas-cancer mortality among White males in a cluster of Louisiana parishes, we examined 876 pairs of certificates of death which occurred in this area during 1960–75. The pancreas-cancer death records were matched to controls by age, race, sex, year of death, and parish of residence. The odds ratios were increased about two-fold for workers in the oil refining and paper manufacturing industries, and slight elevations were seen among residents near refineries and food processing plants. Despite the limited residential and occupational information available on death certificates, this study suggests leads to environmental factor that can be further investigated by a case-control interview study in Louisiana. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEATH
KW  - PANCREATIC cancer
KW  - PARISHES
KW  - DEATH certificates
KW  - INDUSTRIAL workers
KW  - FOOD processing plants
KW  - RESIDENTS
KW  - MANUFACTURING industries
KW  - LOUISIANA
N1  - Accession Number: 4957745; Pickle, Linda W. 1 Gottlieb, Marise S. 2; Affiliation:  1: Analytical Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20205  2: Associate Professor, Tulane University School of Medicine, Department of Medicine and Epidemiology, Box D-55, 1430 Tulane Avenue, New Orleans, LA 70012; Source Info: Mar1980, Vol. 70 Issue 3, p256; Subject Term: DEATH; Subject Term: PANCREATIC cancer; Subject Term: PARISHES; Subject Term: DEATH certificates; Subject Term: INDUSTRIAL workers; Subject Term: FOOD processing plants; Subject Term: RESIDENTS; Subject Term: MANUFACTURING industries; Subject Term: LOUISIANA; NAICS/Industry Codes: 236210 Industrial Building Construction; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Presser, Harriet B.
AU  - Baldwin, Wendy
T1  - Child Care as a Constraint on Employment: Prevalence, Correlates, and Bearing on the Work and Fertility Nexus.
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1980/03//
VL  - 85
IS  - 5
M3  - Article
SP  - 1202
EP  - 1213
SN  - 00029602
AB  - Women with small children, especially the young, black, single, poor, or poorly educated, are constrained from seeking or taking employment because of the lack of child care facilities.
KW  - CHILD care
KW  - MOTHERS -- Employment
KW  - MOTHER & child
KW  - LABOR supply
KW  - LABOR market
KW  - HUMAN fertility
KW  - WOMEN
KW  - EMPLOYMENT (Economic theory)
N1  - Accession Number: 15595638; Presser, Harriet B. 1; Baldwin, Wendy 2; Affiliations: 1 : Community College of Rhode Island, Newport; 2 : Center for Population Research, National Institute of Child Health and Human Development;  Source Info: Mar80, Vol. 85 Issue 5, p1202; Historical Period: 1977; Subject Term: CHILD care; Subject Term: MOTHERS -- Employment; Subject Term: MOTHER & child; Subject Term: LABOR supply; Subject Term: LABOR market; Subject Term: HUMAN fertility; Subject Term: WOMEN; Subject Term: EMPLOYMENT (Economic theory); Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Snippe, H.
AU  - Willers, J. M. N.
AU  - Inman, J. K.
AU  - Merchant, B.
T1  - The specificity of antibody formation in mice following immunization with hapten-carrier complexes mixed with the surfactant, dimethyl dioctadecyl ammonium bromide.
JO  - Immunology
JF  - Immunology
Y1  - 1980/03//
VL  - 39
IS  - 3
M3  - Article
SP  - 361
EP  - 366
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Mice were immunized i.e. with various enlarged haptens conjugated to bovine serum albumin and mixed with the cationic, surface active lipid, dimethyl dioctadecyl ammonium bromide (DDA). This immunization generated delayed-type hypersensitivity (DH) in these mice without detectable concomitant antibody formation. The DH was measured as footpad swelling. However, both direct and indirect hapten-specific PFC could be detected in peripheral lymph nodes and in spleens 4 days after a challenge injection. Although the adjuvant, DDA, promotes a strong cross-reactivity in DH between heterologous hapten--carrier complexes, the antibody-forming cells produced 4 days after challenge showed relatively high specificity for the immunizing hapten. This indicates only weak cross-reactivity at the anti-body-forming cell level co-existent with high cross-reactivity in DH expression to the same hapten-carrier complexes. These results are consistent with the possibility that B-cell receptors may be capable of expressing a greater degree of hapten specificity than T-cell receptors. It is tentatively concluded that Thelper cells participating in antibody formation may represent a subset of the T cells involved in DH. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNIZATION
KW  - IMMUNOGLOBULINS
KW  - HAPTENS
KW  - SURFACE active agents
KW  - SERUM albumin
KW  - MICE as laboratory animals
N1  - Accession Number: 13520411; Snippe, H. 1 Willers, J. M. N. 1 Inman, J. K. 2 Merchant, B. 3; Affiliation:  1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands.  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health.  3: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p361; Subject Term: IMMUNIZATION; Subject Term: IMMUNOGLOBULINS; Subject Term: HAPTENS; Subject Term: SURFACE active agents; Subject Term: SERUM albumin; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stevenson, H. C.
AU  - Fauci, A. S.
T1  - Activation of human B lymphocytes XII. DIFFERENTIAL EFFECTS OF <em>IN VITRO</em> CYCLOPHOSPHAMIDE ON HUMAN LYMPHOCYTE SUBPOPULATIONS INVOLVED IN B-CELL ACTIVATION.
JO  - Immunology
JF  - Immunology
Y1  - 1980/03//
VL  - 39
IS  - 3
M3  - Article
SP  - 391
EP  - 397
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The differential effects of in vitro cyclophosphamide (CY) on subpopulations of normal human peripheral blood lymphocytes involved in the pokeweed mitogen-induced plaque-forming cell (PFC) response against sheep red blood cells were examined. It was found that the plaque-forming B cells in this system are sensitive to CY over a wide concentration range including concentrations which have a minimal effect on overall cell viability. Kinetic experiments revealed that CY exerts its inhibitory effect on the PFC response only if added very early in culture. Thus, it appears that in vitro CY must exert its inhibitory influence on an early phase of polyclonal B-cell activation. When T-cell enriched (TCE) populations were incubated overnight with high concentration CY and then added back in co-culture to fresh autologous B cells, significant enhancement of PFC responses was observed suggesting a selective inhibition or elimination of a regulatory suppressor cell population found in ICE lymphocyte preparations. Helper T cells are relatively resistant to the inhibitory actions of CY. Thus, human B cells appear to be most sensitive to CY, followed in sensitivity by the suppressor cell populations in the 1-cell fraction with relative resistance of the helper T cells. These observations have direct relevance in understanding the mechanisms of selective action of CY on normal human lymphocyte subpopulations with possible application to disease states in man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - CELL culture
KW  - IMMUNOLOGY
KW  - CYTOLOGY
KW  - MITOGENS
KW  - T cells
N1  - Accession Number: 13520516; Stevenson, H. C. 1 Fauci, A. S. 1; Affiliation:  1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p391; Subject Term: LYMPHOCYTES; Subject Term: CELL culture; Subject Term: IMMUNOLOGY; Subject Term: CYTOLOGY; Subject Term: MITOGENS; Subject Term: T cells; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Katz, P.
AU  - Fauci, A. S.
T1  - Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: killing of human erythrocytes and autologous lymphoid cells.
JO  - Immunology
JF  - Immunology
Y1  - 1980/03//
VL  - 39
IS  - 3
M3  - Article
SP  - 407
EP  - 416
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin lgG (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while I cells with surface Fc receptors for IgM (TM) displayed no ADCC activity TG-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIBODY-dependent cell cytotoxicity
KW  - LYMPHOCYTES
KW  - ERYTHROCYTES
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGY
KW  - CELL receptors
N1  - Accession Number: 13520670; Katz, P. 1 Fauci, A. S. 1; Affiliation:  1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Bethesda. Maryland U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p407; Subject Term: ANTIBODY-dependent cell cytotoxicity; Subject Term: LYMPHOCYTES; Subject Term: ERYTHROCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGY; Subject Term: CELL receptors; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - King, Haitung
AU  - Locke, Frances B.
T1  - Chinese in the United States: A Century of Occupational Transition.
JO  - International Migration Review
JF  - International Migration Review
Y1  - 1980///Spring1980
VL  - 14
IS  - 1
M3  - Article
SP  - 15
EP  - 42
SN  - 01979183
AB  - Examines the occupational roles assumed by Chinese Americans over the past century and assesses the degree to which these were dictated by legal and socioeconomic barriers.
KW  - OCCUPATIONS
KW  - CAREER development
KW  - SOCIOECONOMICS
KW  - SOCIOLOGY
KW  - HEALTH status indicators
KW  - ENTREPRENEURSHIP
KW  - SOCIAL structure
KW  - LAW
KW  - ECONOMIC history
KW  - CHINESE Americans
N1  - Accession Number: 16484939; King, Haitung 1; Locke, Frances B. 2; Affiliations: 1 : National Cancer Institute And Georgetown University.; 2 : National Cancer Institute.;  Source Info: Spring1980, Vol. 14 Issue 1, p15; Historical Period: 1870 to 1980; Subject Term: OCCUPATIONS; Subject Term: CAREER development; Subject Term: SOCIOECONOMICS; Subject Term: SOCIOLOGY; Subject Term: HEALTH status indicators; Subject Term: ENTREPRENEURSHIP; Subject Term: SOCIAL structure; Subject Term: LAW; Subject Term: ECONOMIC history; Subject Term: CHINESE Americans; Number of Pages: 28p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - GEN
AU  - Hearing, Vincent J.
T1  - TYROSINASE HYDROXYLATION.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/03//
VL  - 74
IS  - 3
M3  - Letter
SP  - 183
EP  - 183
SN  - 0022202X
AB  - Presents a letter to the editor about incapability of mammalian tyrosinase of tyrosine hydroxylation.
KW  - LETTERS to the editor
KW  - PHENOL oxidase
N1  - Accession Number: 12535096; Hearing, Vincent J. 1; Affiliation:  1: Senior Investigator Dermatology Branch National Cancer Institute.; Source Info: Mar1980, Vol. 74 Issue 3, p183; Subject Term: LETTERS to the editor; Subject Term: PHENOL oxidase; Number of Pages: 1/2p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12535096
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tarone, Robert E.
AU  - Gart, John J.
T1  - On the Robustness of Combined Tests for Trends in Proportions.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1980/03//
VL  - 75
IS  - 369
M3  - Article
SP  - 110
SN  - 01621459
AB  - Several models with monotone trend in proportions are considered for 2 x I x J contingency tables. For one stratum (I = 1) and broad regularity conditions, the C(alpha) test statistic for testing for trend is shown to be fully efficient for all choices of the model with monotone trend. For several strata, the efficiency of each C(alpha) test is compared with the efficiency of the C(alpha) test appropriate when each of the other models holds. These relative efficiencies are used for choosing the most robust tests in a variety of sampling situations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICS
KW  - DISTRIBUTION (Probability theory)
KW  - ECONOMIC trends
KW  - SAMPLING (Statistics)
KW  - MATHEMATICAL statistics
KW  - PROBABILITY theory
KW  - STATISTICAL hypothesis testing
KW  - CONTINGENCY tables
KW  - 2× J contingency tables.
KW  - C(α) test statistics
KW  - Pitman asymptotic relative efficiencies
N1  - Accession Number: 4599761; Tarone, Robert E. 1; Gart, John J. 2; Affiliations: 1: Mathematical Statistician, Biometry Branch, National Cancer Institute, Landow Building, Room 5C25, Bethesda, MD 20205.; 2: Head, Mathematical Statistics and Applied Mathematics Section, Biometry Branch, National Cancer Institute, Landow Building, Room 5C25, Bethesda, MD 20205.; Issue Info: Mar1980, Vol. 75 Issue 369, p110; Thesaurus Term: STATISTICS; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ECONOMIC trends; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICAL hypothesis testing; Subject Term: CONTINGENCY tables; Author-Supplied Keyword: 2× J contingency tables.; Author-Supplied Keyword: C(α) test statistics; Author-Supplied Keyword: Pitman asymptotic relative efficiencies; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2011-08325-011
AN  - 2011-08325-011
AU  - Goldberg, Solomon C.
AU  - Eckert, Elke D.
AU  - Casper, Regina C.
AU  - Halmi, Katherine A.
AU  - Davis, John M.
AU  - Roper, Margaret T.
T1  - Factors influencing hospital differences in weight gain in anorexia nervosa.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1980/03//
VL  - 168
IS  - 3
SP  - 181
EP  - 183
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Goldberg, Solomon C., Department of Psychiatry, Medical College of Virginia, MCV Station 710, Richmond, VA, US, 23298
N1  - Accession Number: 2011-08325-011. PMID: 7354320 Partial author list: First Author & Affiliation: Goldberg, Solomon C.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110801. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Anorexia Nervosa; Hospitals; Prognosis; Treatment; Weight Gain. Minor Descriptor: Experience Level. Classification: Eating Disorders (3260); Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Mar, 1980. Copyright Statement: Williams & Wilkins Co. 1980. 
AB  - In a study of 105 anorexia nervosa patients, large hospital differences were found in weight gain which corresponded exactly to the amount of experience that each hospital had had in treating this disorder, and also corresponded to the degree of milieu structure imposed by each hospital. A further hypothesis to account for the hospital differences was in terms of the prognostic quality of the patients recruited to each hospital. To test the latter hypothesis, a number of prognostic indicators which had already been shown to be related to weight gain were statistically controlled by means of partial correlation. When this was done, the large hospital differences vanished, indicating that they were indeed a function of the qualities the patients brought with them to the hospital rather than what the hospital and its staff did to the patients. The results also indicate that the more experienced investigators seem to be able to recruit patients with better prognoses, whereas the less experienced ones are referred other clinicians' treatment failures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hospital differences
KW  - weight gain
KW  - anorexia nervosa
KW  - experience
KW  - prognosis
KW  - treatment
KW  - 1980
KW  - Anorexia Nervosa
KW  - Hospitals
KW  - Prognosis
KW  - Treatment
KW  - Weight Gain
KW  - Experience Level
KW  - 1980
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH-26218; MH- 26409; MH-26310. Recipients: No recipient indicated
DO  - 10.1097/00005053-198003000-00011
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-08325-018
AN  - 2011-08325-018
AU  - Eckardt, Michael J.
T1  - Review of The hippocampus as a cognitive map.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1980/03//
VL  - 168
IS  - 3
SP  - 191
EP  - 192
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
N1  - Accession Number: 2011-08325-018. Partial author list: First Author & Affiliation: Eckardt, Michael J.; National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, US. Release Date: 20110801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Maps; Hippocampus. Minor Descriptor: Anatomy; Behavior; Neurobiology; Physiology; Semantics. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Reviewed Item: John, Okeefe; Lynn, Nadel. The hippocampus as a cognitive map=Oxford University Press, New York, xiv + 570 pp. $30.00; 1978. Page Count: 2. Issue Publication Date: Mar, 1980. Copyright Statement: Williams & Wilkins Co. 1980. 
AB  - Reviews the book, The hippocampus as a cognitive map by Okeefe John and Nadel Lynn (1978). The authors have reviewed the anatomy, physiology, and behavior associated with the hippocampus. The authors postulate that the hippocampus is functionally different from most other areas of the brain in that it has an innate capability of representing. The next section of the book consists of brief and, in general, excellent reviews of the anatomy and physiology of the hippocampus. The remainder of the book is devoted to showing that the spatiotemporal mapping function proposed for the hippocampus can be used to predict behavioral changes associated with hippocampal dysfunction. Finally, behavioral performance in humans with presumed damage to the hippocampus is examined, and the authors conclude that semantic mapping is conducted in the left hippocampus, whereas the spatial mapping system postulated for infrahuman is located in the right hippocampus. This book should be of widespread interest because of its incorporation of information from a number of different disciplines including philosophy, neurobiology, and psychology into a novel theory of how a clinically relevant brain structure works. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hippocampus
KW  - cognitive maps
KW  - neurobiology
KW  - semantics
KW  - anatomy
KW  - physiology
KW  - behavior
KW  - spatiotemporal mapping
KW  - 1980
KW  - Cognitive Maps
KW  - Hippocampus
KW  - Anatomy
KW  - Behavior
KW  - Neurobiology
KW  - Physiology
KW  - Semantics
KW  - 1980
U2  - John, Okeefe; Lynn, Nadel. (1978); The hippocampus as a cognitive map; Oxford University Press, New York, xiv + 570 pp. $30.00
DO  - 10.1097/00005053-198003000-00018
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - NORDEN, BETH
AU  - BATRA, SUZANNE W. T.
AU  - FALES, HENRY M.
AU  - HEFETZ, ABRAHAM
AU  - SHAW, G. JOHN
T1  - Anthophora Bees: Unusual Glycerides from Maternal Dufour's Glands Serve as Larval Food and Cell Lining.
JO  - Science
JF  - Science
Y1  - 1980/03/07/
VL  - 207
IS  - 4435
M3  - Article
SP  - 1095
EP  - 1097
SN  - 00368075
AB  - The Dufour's gland of Anthophora abrupta, a solitary bee, secretes a complex mixture of liquid triglycerides containing one long-chain and two shortchain fatty acids. This is applied inside the earthen brood cells and added to the provision, where it is converted, perhaps by enzymes from the bee's saliva or gut, to solid diglycerides that are later eaten by the bee larvae. This use of Dufour's gland secretion as food and its nutritive function are reminiscent of the royaljelly secreted by honey bees. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85266482; NORDEN, BETH 1; BATRA, SUZANNE W. T. 2; FALES, HENRY M. 3; HEFETZ, ABRAHAM 3; SHAW, G. JOHN 4; Affiliations: 1: Department of Biological Sciences, Towson State University, Towson, Maryland 21204; 2: Beneficial Insect Introduction Laboratory, Department of Agriculture, Beltsville, Maryland 20705; 3: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 4: Borriston Research Laboratory, Temple Hills, Maryland 20031; Issue Info: 3/ 7/1980, Vol. 207 Issue 4435, p1095; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - OSKARSSON, MARIANNE
AU  - MCCLEMENTS, WILLIAM L.
AU  - BLAIR, DONALD G.
AU  - MAIZEL, J. V.
AU  - VANDE WOUDE, GEORGE F.
T1  - Properties of a Normal Mouse Cell DNA Sequence (sarc) Homologous to the src Sequence of Moloney Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1980/03/14/
VL  - 207
IS  - 4436
M3  - Article
SP  - 1222
EP  - 1224
SN  - 00368075
AB  - A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balbic genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage λ. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85196084; OSKARSSON, MARIANNE 1; MCCLEMENTS, WILLIAM L. 1; BLAIR, DONALD G. 2; MAIZEL, J. V. 3; VANDE WOUDE, GEORGE F. 4; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Laboratory of Viral Carcinogenesis, National Cancer Institute; 3: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 4: Laboratory of Molecular Virology, National Cancer Institute; Issue Info: 3/14/1980, Vol. 207 Issue 4436, p1222; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Felber, Barbara K.
AU  - Maurhofer, Susanne
AU  - Jaggi, Rolf B.
AU  - Wyler, Toni
AU  - Wahli, Walter
AU  - Ryffel, Gerhart U.
AU  - Weber, Rudolf
T1  - Isolation and Translation <em>in vitro</em> of Four Related Vitellogenin mRNAs of Estrogen-Stimulated <em>Xenopus laevis</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/03/15/
VL  - 105
IS  - 1
M3  - Article
SP  - 17
EP  - 24
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Cloning of vitellogenin cDNA of Xenopus laevis revealed that vitellogenin is encoded in a small family of genes representing two distantly related main groups A and B, each comprising two more closely related subgroups A1, A2, and B1, B2 respectively. To characterize the proteins derived from these genes we have isolated the corresponding mRNAs by hybridizing, under stringent conditions, cytoplasmic poly(A)-containing RNA from the liver of estrogen-stimulated Xenopus to filter-bound cDNA clones containing sequences specific for all four vitellogenin genes. Hybridization of the isolated mRNAs with nick-translated cDNA clones revealed that contamination of the mRNAs by those of the other main group was less than 0.1%. Melting curves of the hybrids prepared with the isolated mRNAs and cDNA clones specific for the four vitellogenin genes showed that the isolated vitellogenin mRNAs are also specific for the four subgroups. Analysis of R loops formed between isolated mRNAs and cDNA clones representing the corresponding subgroup further indicated about 10% cross-contamination between the more closely related mRNAs. In a reticulocyte lysate each of the four mRNAs coded for a 200000-Mr protein immuno- precipitable by monospecific vitellogenin antibody. From these results we conclude that the four different mRNAs A1, A2, B1 and B2, which all can be isolated efficiently, code for vitellogenin and are expressed simultaneously in response to estrogen stimulation. [ABSTRACT FROM AUTHOR]
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KW  - MESSENGER RNA
KW  - XENOPUS laevis
KW  - ESTROGEN
KW  - ANTISENSE DNA
KW  - PROTEINS
KW  - NUCLEOTIDE sequence
KW  - GENES
N1  - Accession Number: 13483547; Felber, Barbara K. 1 Maurhofer, Susanne 1 Jaggi, Rolf B. 1 Wyler, Toni 1 Wahli, Walter 1 Ryffel, Gerhart U. 1 Weber, Rudolf 1; Affiliation:  1: Division of Cell and Development Biology, Department of Zoology, University of Bern, and Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland; Source Info: 3/15/80, Vol. 105 Issue 1, p17; Subject Term: MESSENGER RNA; Subject Term: XENOPUS laevis; Subject Term: ESTROGEN; Subject Term: ANTISENSE DNA; Subject Term: PROTEINS; Subject Term: NUCLEOTIDE sequence; Subject Term: GENES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - TALBOT, BERNARD
T1  - New Recombinant DNA Guidelines.
JO  - Science
JF  - Science
Y1  - 1980/03/21/
VL  - 207
IS  - 4437
M3  - Article
SP  - 1296
EP  - 1296
SN  - 00368075
N1  - Accession Number: 85196089; TALBOT, BERNARD 1; Affiliations: 1: Office, Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 3/21/1980, Vol. 207 Issue 4437, p1296; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VENTER, J. CRAIG
AU  - FRASER, CLAIRE M.
AU  - HARRISON, LEN C.
T1  - Autoantibodies to β2-Adrenergic Receptors: A Possible Cause of Adrenergic Hyporesponsiveness in Allergic Rhinitis and Asthma.
JO  - Science
JF  - Science
Y1  - 1980/03/21/
VL  - 207
IS  - 4437
M3  - Article
SP  - 1361
EP  - 1363
SN  - 00368075
AB  - Autoaintibodies to β2-adrenergic receptors have been identified in the seruinm of one patient with allergic rhinitis (''hay fever'" and two patients with asthma. The aintibodies precipitate solubilized dog luing βreceptors in an indirect iminunoprecipitation assay and inhibit the specific binding of todine-125-labeled iodohydroxybenzylpindolol to membrane-associated receptors fromn dog lung, calf lung, and humaon placenta. Ligand binding to canine heart β, receptors is not affected by the anitibodies. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85196100; VENTER, J. CRAIG 1; FRASER, CLAIRE M. 1; HARRISON, LEN C. 2; Affiliations: 1: Department of Pharmacology and Therapeutics, School of Medicine, State University of New York, Buffalo 14214; 2: Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/21/1980, Vol. 207 Issue 4437, p1361; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LAPPÉ, DONALD L.
AU  - LAKATTA, EDWARD G.
T1  - Intensity Fluctuation Spectroscopy Monitors Contractile Activation in "Resting" Cardiac Muscle.
JO  - Science
JF  - Science
Y1  - 1980/03/21/
VL  - 207
IS  - 4437
M3  - Article
SP  - 1369
EP  - 1371
SN  - 00368075
AB  - Intensity flutctations in a laser beam by scattered by nonibeatinig isolatecd rat cardiac muscle varied directly with the calcium concentration in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect and interaction of calcium with the myofilaments. The demonstration that both a portion of resting force and the frequiency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85196103; LAPPÉ, DONALD L. 1; LAKATTA, EDWARD G. 1; Affiliations: 1: Cardiovascular Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224; Issue Info: 3/21/1980, Vol. 207 Issue 4437, p1369; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SERABJIT-SINGH, COSETTE J.
AU  - WOLF, C. ROLAND
AU  - PHILPOT, RICHARD M.
AU  - PLOPPER, CHARLES G.
T1  - Cytochrome P-450: Localization in Rabbit Lung.
JO  - Science
JF  - Science
Y1  - 1980/03/28/
VL  - 207
IS  - 4438
M3  - Article
SP  - 1469
EP  - 1470
SN  - 00368075
AB  - Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and severalextrahepatic tissues of mammals, including humans. A form of cytochrome P450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85266513; SERABJIT-SINGH, COSETTE J. 1; WOLF, C. ROLAND 1; PHILPOT, RICHARD M. 1; PLOPPER, CHARLES G. 2; Affiliations: 1: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Laboratory of Pulmonary Function and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park; Issue Info: 3/28/1980, Vol. 207 Issue 4438, p1469; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Cutter, Gary
AU  - Heyden, Siegfried
AU  - Kasteler, Josephine
AU  - Kraus, Jess F.
AU  - Lee, Eun Sul
AU  - Shipley, Thomas
AU  - Stromer, Mitchell
AU  - Mba
T1  - Mortality Surveillance in Collaborative Trials.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/04//
VL  - 70
IS  - 4
M3  - Article
SP  - 394
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The Hypertension Detection and Follow-Up Program (HDFP) carried out two pilot surveillances covering the enumerated population to test procedures to be used in assessing the ability of the program to influence life expectancy in the total population. A rigorously sequenced pilot survey of 2,611 households was conducted and carefully monitored through two mailings, telephone contacts, home visits, and communication with "contact" persons. The response rates at each stage varied among the 13 centers. Overall, there was a 42.7 per ¢ yield from the first mailing, 42.5 per ¢ of those receiving a second mailing was completed; 78.0 per ¢ for telephone 61.3 per ¢ for the home visits and 55.2 per ¢ from the "contact" persons. Overall, 97.4 per ¢ of all persons had vital status ascertained.  The second phase relaxed the rigorous sequential survey requirements and reduced the reporting requirements from every ten days to monthly. Overall, 93.3 per ¢ were successfully ascertained. Reduced survey structure, slightly increased mobility (from 12 per ¢ to 13 per ¢), increased workload from 200 to 400 households per center, and a longer time interval between initial enumeration and the mortality ascertainment are among the reasons for performance decline. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOUSEHOLD surveys
KW  - MORTALITY -- Statistics
KW  - HYPERTENSION
KW  - PATIENTS
KW  - LIFE expectancy
KW  - HEALTH surveys
KW  - DEMOGRAPHY
KW  - POPULATION research
KW  - TELEPHONE surveys
KW  - MAILING lists (Lists of addresses)
N1  - Accession Number: 4952932; Cutter, Gary 1 Heyden, Siegfried 1 Kasteler, Josephine 1 Kraus, Jess F. 1 Lee, Eun Sul 1 Shipley, Thomas 1 Stromer, Mitchell 1 Mba; Affiliation:  1: Scientific Project Officer, Hypertension Detection and Follow-Up Program, DHVD, National Heart, Lung, and Blood Institute, NIH, Room 6C08, Federal Building, 7550 Wisconsin Avenue, Bethesda, MD 20205.; Source Info: Apr1980, Vol. 70 Issue 4, p394; Subject Term: HOUSEHOLD surveys; Subject Term: MORTALITY -- Statistics; Subject Term: HYPERTENSION; Subject Term: PATIENTS; Subject Term: LIFE expectancy; Subject Term: HEALTH surveys; Subject Term: DEMOGRAPHY; Subject Term: POPULATION research; Subject Term: TELEPHONE surveys; Subject Term: MAILING lists (Lists of addresses); NAICS/Industry Codes: 511140 Directory and Mailing List Publishers; NAICS/Industry Codes: 541860 Direct Mail Advertising; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nagel, James E.
T1  - IMMUNOGLOBULIN SYNTHESIS.
JO  - BioScience
JF  - BioScience
Y1  - 1980/04//
VL  - 30
IS  - 4
M3  - Book Review
SP  - 263
EP  - 263
SN  - 00063568
AB  - The article reviews the book "Cells of Immunoglobulin Synthesis," edited by Benvenuto Pernis and Henry J. Vogel.
KW  - Immunoglobulins
KW  - Nonfiction
KW  - Pernis, Benvenuto
KW  - Vogel, Henry J.
KW  - Cells of Immunoglobulin Synthesis (Book)
N1  - Accession Number: 28049114; Nagel, James E. 1; Affiliations: 1 : National Institute on Aging Gerontology Research Center Baltimore City Hospitals Baltimore, MD 21224;  Source Info: Apr1980, Vol. 30 Issue 4, p263; Subject Term: Immunoglobulins; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 464
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Giambra, Leonard M.
T1  - A FACTOR ANALYSIS OF THE ITEMS OF THE IMAGINAL PROCESSES INVENTORY.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1980/04//
VL  - 36
IS  - 2
M3  - Article
SP  - 383
EP  - 409
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article focuses on the Imaginal Processes Inventory (IPI). The Imaginal Processes inventory consists of two parts. In Part I are 24 items that deal with day- and night-dreaming frequency or propensity. All items contain five alternatives, which implies a quantitative continuum that is not identical for all items of Part I. Furthermore, items that appear to have little or no relation to any of the major dimensions of mental processes measured by the IPI could be dropped, which would result in a much-needed shortened form.
KW  - SLEEP disorders
KW  - MENTAL illness
KW  - FACTOR analysis
KW  - CORRELATION (Statistics)
KW  - PATH analysis (Statistics)
KW  - INVENTORIES
N1  - Accession Number: 15829167; Giambra, Leonard M. 1; Affiliation:  1: Gerontology Research Center (Baltimore), National Institute on Aging, and National Institutes of Health, Department of Health Education and Welfare, Bethesda, and the Baltimore City Hospitals.; Source Info: Apr1980, Vol. 36 Issue 2, p383; Subject Term: SLEEP disorders; Subject Term: MENTAL illness; Subject Term: FACTOR analysis; Subject Term: CORRELATION (Statistics); Subject Term: PATH analysis (Statistics); Subject Term: INVENTORIES; Number of Pages: 27p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hintner, Helmut
AU  - Fritsch, Peter I.
AU  - Foidart, Jean-Michel
AU  - Stingl, Georg
AU  - Schuler, Gerold
AU  - Katz, Stephen I.
T1  - Expression of Basement Membrane Zone Antigens at the Dermo-epibolic Junction in Organ Cultures of Human Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/04//
VL  - 74
IS  - 4
M3  - Article
SP  - 200
EP  - 204
SN  - 0022202X
AB  - Using the epithelial outgrowth in organ cultures of human skin ("epiboly") as a model system for basement membrane zone neogenesis, the emergence of various antigenic determinants of the junction zone (bullous pemphigoid antigen, type IV collagen and laminin) was studied and the time sequence of their appearance assessed. All 3 antigens were found at the newly built dermo-epibolic junction; their synthesis, however, followed a distinct time sequence: bullous pemphigoid antigens emerged synchronously with the advancing tip of the migrating epithelium, whereas type IV collagen and to a greater extent, laminin, appeared with considerable delay. At the ultrastructural level, the formation of basal lamina accompanied the emergence of type LV collagen and laminin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN diseases
KW  - IMMUNOGLOBULINS
KW  - ANTIGENS
KW  - CONNECTIVE tissues
KW  - EPITHELIUM
KW  - COLLAGEN
N1  - Accession Number: 12541715; Hintner, Helmut 1 Fritsch, Peter I. 1 Foidart, Jean-Michel 2,3 Stingl, Georg 1 Schuler, Gerold 1 Katz, Stephen I. 2,3; Affiliation:  1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.  2: Dermatology Branch, National Cancer Institute and Laboratory of Developmental Biology and Anomalies, Bethesda, Maryland, U.S.A.  3: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr80, Vol. 74 Issue 4, p200; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Subject Term: CONNECTIVE tissues; Subject Term: EPITHELIUM; Subject Term: COLLAGEN; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12541715
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1981-11025-001
AN  - 1981-11025-001
AU  - Windle, Charles
T1  - Correlates of community mental health center underservice to non-Whites.
JF  - Journal of Community Psychology
JO  - Journal of Community Psychology
JA  - J Community Psychol
Y1  - 1980/04//
VL  - 8
IS  - 2
SP  - 140
EP  - 146
CY  - US
PB  - John Wiley & Sons
SN  - 0090-4392
SN  - 1520-6629
N1  - Accession Number: 1981-11025-001. PMID: 10245917 Partial author list: First Author & Affiliation: Windle, Charles; National Institute of Mental Health, Rockville, MD. Release Date: 19810501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Community Mental Health Centers; Community Mental Health Services; Demographic Characteristics; Help Seeking Behavior. Minor Descriptor: Blacks; Racial and Ethnic Groups. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 7. Issue Publication Date: Apr, 1980. 
AB  - Examined the relationships between relatively low utilization rates for non-Whites and catchment area demography center service characteristics for 142 federally funded community mental health centers. Center characteristics were less strongly related to relative utilization by non-Whites than were area demographic characteristics. Several characteristics of the Black population were among those most highly associated with relative non-White utilization rates. (6 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - demographic characteristics of catchment areas & characteristics of center's services
KW  - community mental health center underservice to non-Whites
KW  - 1980
KW  - Client Characteristics
KW  - Community Mental Health Centers
KW  - Community Mental Health Services
KW  - Demographic Characteristics
KW  - Help Seeking Behavior
KW  - Blacks
KW  - Racial and Ethnic Groups
KW  - 1980
DO  - 10.1002/1520-6629(198004)8:2<140::AID-JCOP2290080207>3.0.CO;2-T
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-42212-025
AN  - 2013-42212-025
AU  - Shore, Milton F.
T1  - Review of The mental health interview: Research and application.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1980/04//
VL  - 50
IS  - 2
SP  - 376
EP  - 376
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42212-025. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Demographic Characteristics; Diagnosis; Interviews; Mental Health; Social Class. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Pope, Benjamin. The mental health interview: Research and application=540 pp. $40.00 Pergamon Press, Elmsford, NY; 1979. Page Count: 1. Issue Publication Date: Apr, 1980. 
AB  - Reviews the book, The Mental Health Interview: Research and Application by Benjamin Pope (1979). The purpose is well accomplished. Pope has produced an impressive, erudite, comprehensive resource book of current research knowledge on the mental health interview both in assessment and treatment. The research is described in detail in the 500 pages and is divided into areas of communication, relationship , demographic variables (in interviewer and interviewee, including sex, race, and social class), and temporary and sequential effects. The volume can certainly criticize the reader to the interactional experts of interviews. Rut although the author’s scholarship is evident, his own language and the minor attention to diagnostic categories, as well as minimal discussion of practice issues, limit the book’s value to the practitioner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - demographic variables
KW  - diagnostic categories
KW  - mental health interview
KW  - research knowledge
KW  - social class
KW  - 1980
KW  - Demographic Characteristics
KW  - Diagnosis
KW  - Interviews
KW  - Mental Health
KW  - Social Class
KW  - 1980
U2  - Pope, Benjamin. (1979); The mental health interview: Research and application; 540 pp. $40.00 Pergamon Press, Elmsford, NY
DO  - 10.1037/h0098884
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - GALLAGER, DOROTHY W.
AU  - MALLORGA, PIERRE
T1  - Diphenylhydantoin: Pre- and Postnatal Administration Alters Diazepam Binding in Developing Rat Cerebral Cortex.
JO  - Science
JF  - Science
Y1  - 1980/04/04/
VL  - 208
IS  - 4439
M3  - Article
SP  - 64
EP  - 66
SN  - 00368075
AB  - Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats from fetal day 16 to maturation. In contrast, significant decreases in tritiated diazepam binding were observed in 2- and 3-week-old rats that were exposed in utero to diphenylhydantoin. These changes can be correlated with reported increases in seizure susceptibility after prenatal exposure to diphenylhydantoin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85136771; GALLAGER, DOROTHY W. 1; MALLORGA, PIERRE 1; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 4/ 4/1980, Vol. 208 Issue 4439, p64; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - J. CRANE, MARK ST.
AU  - DVORAK, JAMES A.
T1  - Vertebrate Cells Express Protozoan Antigen After Hybridization.
JO  - Science
JF  - Science
Y1  - 1980/04/11/
VL  - 208
IS  - 4440
M3  - Article
SP  - 194
EP  - 196
SN  - 00368075
AB  - Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol. Hybrid cells were selected on the basis of T. cruzi DNA complementation of biochemical deficiencies in the vertebrate cells. Some clones of the hybrid cells expressed T. cruzi-specific antigen. It might be possible to use selected antigens obtainedfrom the hybrids as vaccines for immunodiagnosis or for elucidation of the pathogenesis of Chagas' disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159105; J. CRANE, MARK ST. 1; DVORAK, JAMES A. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/11/1980, Vol. 208 Issue 4440, p194; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SITARAM, N.
AU  - NURNBERGER JR., JOHN I.
AU  - GERSHON, ELLIOT S.
AU  - GILLIN, J. CHRISTIAN
T1  - Faster Cholinergic REM Sleep Induction in Euthymic Patients with Primary Affective Illness.
JO  - Science
JF  - Science
Y1  - 1980/04/11/
VL  - 208
IS  - 4440
M3  - Article
SP  - 200
EP  - 202
SN  - 00368075
AB  - Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159108; SITARAM, N. 1; NURNBERGER JR., JOHN I. 1; GERSHON, ELLIOT S. 1; GILLIN, J. CHRISTIAN 2; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Biological Psychiatry Branch, National Institute of Mental Health and Laboratory of Clinical Psychopharmacology, St. Elizabeth's Hospital, Washington, D.C. 20032; Issue Info: 4/11/1980, Vol. 208 Issue 4440, p200; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lin, Thomas T.-S.
AU  - Li, Steven S.-L.
T1  - Purification and Physicochemical Properties of Ricins and Agglutinins from <em>Ricinus communis</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/04/15/
VL  - 105
IS  - 3
M3  - Article
SP  - 453
EP  - 459
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Two toxin ricins and two agglutinins have been purified from the seeds of Ricinus communis by an improved procedure based on ion-exchange chromatography and gel filtration. One of the two purified ricins binds to Sepharose 4B while the other does not. The physicochemical properties of the four Ricinus lectins are presented and the possible relationships of these Ricinus lectins to those previously described are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RICIN
KW  - AGGLUTININS
KW  - CASTOR oil plant
KW  - ION exchange chromatography
KW  - GEL permeation chromatography
KW  - SEPHAROSE
KW  - LECTINS
KW  - BLOOD cells
N1  - Accession Number: 13486614; Lin, Thomas T.-S. 1 Li, Steven S.-L. 1; Affiliation:  1: Department of Microbiology, Mount Sinai School of Medicine, New York and National Institute of Environmental Health Sciencs, National Institutes of Health, Research Triangle Park; Source Info: 4/15/80, Vol. 105 Issue 3, p453; Subject Term: RICIN; Subject Term: AGGLUTININS; Subject Term: CASTOR oil plant; Subject Term: ION exchange chromatography; Subject Term: GEL permeation chromatography; Subject Term: SEPHAROSE; Subject Term: LECTINS; Subject Term: BLOOD cells; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gori, Gio Batta
T1  - The Regulation of Carcinogenic Hazards.
JO  - Science
JF  - Science
Y1  - 1980/04/18/
VL  - 208
IS  - 4441
M3  - Article
SP  - 256
EP  - 261
SN  - 00368075
N1  - Accession Number: 85159116; Gori, Gio Batta 1; Affiliations: 1: Deputy Director, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 4/18/1980, Vol. 208 Issue 4441, p256; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FINK, DAVID J.
AU  - GAINER, HAROLD
T1  - Retrograde Axonal Transport of Endogenous Proteins in Sciatic Nerve Demonstrated by Covalent Labeling in vivo.
JO  - Science
JF  - Science
Y1  - 1980/04/18/
VL  - 208
IS  - 4441
M3  - Article
SP  - 303
EP  - 305
SN  - 00368075
AB  - Extracellularly applied N-succinimidyl [2,3-3H]propionate was used in vivo to covalently label intra-axonal proteins in the rat sciatic nerve. This technique permitted a unique view of axonal transport of proteins independent of biosynthesis. The proteins detected in slow anterograde transport (I to 2 millimeters per day) correspond to cytoskeletal proteins described in previous reports. The slowly retrogradely transported component (3 to 6 millimeters per day) was composed primarily of a single protein with a molecular weight of 68,000. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159142; FINK, DAVID J. 1; GAINER, HAROLD 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/18/1980, Vol. 208 Issue 4441, p303; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MCLAUGHLIN, CHARLES A.
AU  - SCHWARTZMAN, STEVEN M.
AU  - HORNER, BONNIE L.
AU  - JONES, GORDAN H.
AU  - MOFFATT, JOHN G.
AU  - NESTOR JR., JOHN J.
AU  - TEGG, DEREK
T1  - Regression of Tumors in Guinea Pigs After Treatment with Synthetic Muramyl Dipeptides and Trehalose Dimycolate.
JO  - Science
JF  - Science
Y1  - 1980/04/25/
VL  - 208
IS  - 4442
M3  - Article
SP  - 415
EP  - 416
SN  - 00368075
AB  - A high incidence of tumor regression was observed in guinea pigs bearing transplantable, line-10 hepatocellular carcinomas when synthetic muramyl dipeptides combined with trehalose dimycolate in oil-in-water emulsions were injected directly into the tumors. These compounds are promising candidates to replace viable bacillus Calmette-Guérin in cancer immunotherapy in humans and animals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159185; MCLAUGHLIN, CHARLES A. 1; SCHWARTZMAN, STEVEN M. 1; HORNER, BONNIE L. 2; JONES, GORDAN H. 2; MOFFATT, JOHN G. 2; NESTOR JR., JOHN J. 2; TEGG, DEREK 2; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 2: Syntex Research, Palo Alto, California 94304; Issue Info: 4/25/1980, Vol. 208 Issue 4442, p415; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Broder, Samuel
AU  - Muul, Linda
AU  - Marshall, Sandra
AU  - Waldmann, Thomas A.
T1  - Neoplasms of Immunoregulatory T Cells in Clinical Investigation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/05//
VL  - 74
IS  - 5
M3  - Article
SP  - 267
EP  - 271
SN  - 0022202X
AB  - Normal T cells play a critical role in the regulation of humoral immune responses by acting as potentiators (helper cells) or inhibitors (suppressor cells) of the process by which B cells differentiate into immunoglobulin-secreting plasma cells. Certain diseases in which malignant T cells appear to retain an immunoregulatory function are characterized by a propensity of a lymphomatous T-cell population to infiltrate skin. Some cutaneous T-cell lymphoinas, as well as some T-cell neoplasms without derinatologic involvement, provide a homogeneous supply of T lymphocytes which act as immunoregulators. The availability of neoplastic T cells with immunoregulatory properties could accelerate the serologic and biochemical analysis of the cellular control of normal immunity in man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - TUMORS
KW  - IMMUNE response -- Regulation
KW  - SUPPRESSOR cells
KW  - CONNECTIVE tissue cells
KW  - LYMPHOCYTES
N1  - Accession Number: 12543356; Broder, Samuel 1 Muul, Linda 1 Marshall, Sandra 1 Waldmann, Thomas A. 1; Affiliation:  1: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p267; Subject Term: T cells; Subject Term: TUMORS; Subject Term: IMMUNE response -- Regulation; Subject Term: SUPPRESSOR cells; Subject Term: CONNECTIVE tissue cells; Subject Term: LYMPHOCYTES; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543356
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shevach, Ethan M.
T1  - The Role of the Major Histocompatibility Complex in the Regulation of Macrophage-T Lymphocyte Interaction.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/05//
VL  - 74
IS  - 5
M3  - Article
SP  - 289
EP  - 291
SN  - 0022202X
AB  - The proliferative response of guinea pig T lymphocytes which have been primed <em>in vivo</em> can only be induced by antigen-pulsed syngeneic macrophages. The development of techniques to prime T lymphocytes <em>in vitro</em> has allowed us to demonstrate that the genetic restriction on the interaction of the macrophage and T lymphocyte is regulated by the Ia antigens of the macrophage used during the initial sensitization step. Following removal of alloreactive cells, T cells can be sensitized to antigen-treated allogeneic macrophages. It thus appears likely that T cells do not recognize antigen per se, but can only be sensitized to antigen-modified membrane components or to complexes of antigen combined with certain membrane molecules. We postulate that the Ia antigens themselves are the products of the immune response genes and function in both macrophages and B lymphocytes as antigen recognition structures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTOCOMPATIBILITY
KW  - MACROPHAGES
KW  - T cells
KW  - LYMPHOCYTES
KW  - CELL interaction (Biology)
KW  - TRANSPLANTATION immunology
N1  - Accession Number: 12543471; Shevach, Ethan M. 1; Affiliation:  1: Laboratory of immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p289; Subject Term: HISTOCOMPATIBILITY; Subject Term: MACROPHAGES; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: CELL interaction (Biology); Subject Term: TRANSPLANTATION immunology; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543471
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tamaki, Kunihiko
AU  - Stingl, Georg
AU  - Katz, Stephen I.
T1  - The Origin of Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/05//
VL  - 74
IS  - 5
M3  - Article
SP  - 309
EP  - 311
SN  - 0022202X
AB  - Langerhans cells constitute a morphologically well-characterized subpopulation (3-8%) of mammalian epidermal cells and, in contrast to the bulk of epidermal cells, bear Fc-IgG and C3 receptors, express immune response associated (Ia) antigens, and function as antigen presenting cells and allogeneic stimulatory cells to primed T lymphocytes. The purpose of this study was to define the ontogeny of Langerhans cells which has been a subject of considerable debate since their discovery in 1868. We have demonstrated that, after 3 weeks, most of the Langerhans cells in parental skin which had been transplanted onto F1 hybrids are of recipient origin whereas keratinocytes remain of donor origin, which indicates that the LC are derived from a mobile pool of cells. Furthermore, in studies of skin from radiation-induced bone marrow chimeric animals we have found that, depending upon the strain combination, up to 80% of the epidermal Langerhans cells are derived from the bone marrow of the donor animals. These studies indicate that epidermal Langerhans cells are derived from and are continuously replenished by a mobile pool of precursor cells which for the most part originate in bone marrow. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - EPIDERMIS
KW  - CELL receptors
KW  - IMMUNE response
KW  - T cells
KW  - LYMPHOCYTES
N1  - Accession Number: 12543533; Tamaki, Kunihiko 1 Stingl, Georg 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p309; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; Subject Term: CELL receptors; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: LYMPHOCYTES; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543533
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stingl, Georg
AU  - Katz, Stephen I.
AU  - Green, Ira
AU  - Shevach, Ethan M.
T1  - The Functional Role of Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/05//
VL  - 74
IS  - 5
M3  - Article
SP  - 315
EP  - 318
SN  - 0022202X
AB  - Langerhans cells represent a subpopulation of mammalian epidermal cells. The recent findings that these cells are the only epidermal cells which express Fc-IgG receptors, C3 receptors and La antigens support the early suggestion that they are related to cells from the monocyte-macrophage-histiocyte series. In this report, evidence is presented that epidermal Langerhans cell can replace Ia-bearing macrophages in their capacity to induce antigen-specific and allogeneic T cell activation. The possible clinical implications of these findings are discussed with regard to the role of Langerhans cells as sensitizing factors in contact hypersensitivity and skin graft rejection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - CONNECTIVE tissue cells
KW  - EPIDERMIS
KW  - CELL receptors
KW  - ANTIGEN presenting cells
KW  - T cells
N1  - Accession Number: 12543548; Stingl, Georg 1 Katz, Stephen I. 2 Green, Ira 2 Shevach, Ethan M. 2; Affiliation:  1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.  2: Dermatology Branch, National Cancer Institute and Lab. of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p315; Subject Term: LANGERHANS cells; Subject Term: CONNECTIVE tissue cells; Subject Term: EPIDERMIS; Subject Term: CELL receptors; Subject Term: ANTIGEN presenting cells; Subject Term: T cells; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543548
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lawley, Thomas J.
T1  - Immune Complexes and Reticuloendothelial System Function in Human Disease.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/05//
VL  - 74
IS  - 5
M3  - Article
SP  - 339
EP  - 343
SN  - 0022202X
AB  - The interrelation between the presence of circulating antigen-antibody complexes and the functional status of reticuloendothelial system Fc-receptors was studied in patients with systemic lupus erythematosus and Sjogren's syndrome. Both groups of patients had a high prevalence of circulating immune complexes as detected by the 125I-Clq binding assay and the Raji cell radioimmune assay. A number of patients with both diseases were found to have abnormal reticuloendothelial system Fc-receptor function, as measured by the clearance of IgG-sensitized, 51Cr-labeled autologous erythrocytes. In patients with systemic lupus erythematosus there was a high correlation between the presence and levels of immune complexes and abnormal clearance rates. In Sjogren's syndrome on the other hand there was no correlation between the presence or levels of immune complexes and clearance rates. In this disease patients with normal rates of clearance tended to have disease limited to exocrine glands, while patients with abnormal clearance had evidence of more widespread tissue damage. These findings are consistent with the hypothesis that defective reticuloendothelial system function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue damage. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RETICULO-endothelial system
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - CELL receptors
KW  - LUPUS erythematosus
KW  - SJOGREN'S syndrome
N1  - Accession Number: 12543598; Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p339; Subject Term: RETICULO-endothelial system; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: CELL receptors; Subject Term: LUPUS erythematosus; Subject Term: SJOGREN'S syndrome; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543598
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2011-08329-010
AN  - 2011-08329-010
AU  - Savard, Robert J.
AU  - Rey, Alix C.
AU  - Post, Robert M.
T1  - Halstead-Reitan Category Test in bipolar and unipolar affective disorders: Relationship to age and phase of illness.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1980/05//
VL  - 168
IS  - 5
SP  - 297
EP  - 304
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Savard, Robert J., Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Building 10, Room 3S239, Bethesda, MD, US, 20205
N1  - Accession Number: 2011-08329-010. PMID: 7365494 Partial author list: First Author & Affiliation: Savard, Robert J.; Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Affective Disorders; Age Differences; Disease Course; Errors; Halstead Reitan Neuropsychological Battery. Minor Descriptor: Bipolar Disorder; Major Depression. Classification: Clinical Psychological Testing (2224); Affective Disorders (3211). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Halstead-Reitan Category Test. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 1980. Copyright Statement: The Williams & Wilkins Co. 1980. 
AB  - Unipolar and bipolar affectively disturbed patients were administered the Halstead-Reitan category test when in an unmedicated acutely depressed phase and during recovery. Controls consisted of normal volunteers and spouses. Spouse controls were tested at intervals similar to those of the patients and were utilized to control for age, sex, education, and socioeconomic status. Results showed that depressives in the acute depressed state made significantly more errors than did controls. Older bipolar patients made significantly more errors than younger bipolar or younger unipolar patients. In the recovered state the order remained the same. In spite of a decrease in error scores the older bipolar group remained in the abnormal range, whereas the younger groups scored in the normal range with few exceptions. These data suggest that impaired cognitive functioning may be a factor in the disability associated with the major affective disorders in addition to the distorted affective component usually emphasized. Furthermore, in the case of older bipolar patients, the deficit is more severe and may persist beyond the disappearance of affective signs, suggesting that factors associated with age may play an important role in conjunction with other factors associated with bipolar illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Halstead Reitan Category Test
KW  - bipolar disorder
KW  - major depression
KW  - illness phase
KW  - errors
KW  - age differences
KW  - 1980
KW  - Affective Disorders
KW  - Age Differences
KW  - Disease Course
KW  - Errors
KW  - Halstead Reitan Neuropsychological Battery
KW  - Bipolar Disorder
KW  - Major Depression
KW  - 1980
DO  - 10.1097/00005053-198005000-00010
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-08329-011
AN  - 2011-08329-011
AU  - Donnelly, Edward F.
AU  - Weinberger, Daniel R.
AU  - Waldman, Ivan N.
AU  - Wyatt, Richard Jed
T1  - Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1980/05//
VL  - 168
IS  - 5
SP  - 305
EP  - 308
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Donnelly, Edward F., National Institute of Mental Health, Saint Elizabeths Hospital, William A. White Division, Washington, DC, US, 20032
N1  - Accession Number: 2011-08329-011. PMID: 7365495 Partial author list: First Author & Affiliation: Donnelly, Edward F.; National Institute of Mental Health, Saint Elizabeths Hospital, William A. White Division, Washington, DC, US. Release Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Brain Disorders; Cognitive Impairment; Morphology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Halstead-Reitan Test Battery; Wechsler Adult Intelligence Scale. Methodology: Brain Imaging; Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: May, 1980. Copyright Statement: The Williams & Wilkins Co. 1980. 
AB  - The Halstead-Reitan Battery (HRB), including the Wechsler Adult Intelligence Scale, was administered to 15 young chronic schizophrenic patients in an attempt to identify blindly those patients with evidence of morphological brain abnormalities on prior computed tomography (CT). The CT scan status of 12 of 15 (80 per cent) patients was correctly identified solely on the basis of neuropsychological testing. These results supported our hypothesis that impairment on the HRB in chronic schizophrenic patients was associated with morphological abnormalities on the CT scan, and that the positive and negative CT scans of these patients could be predicted accurately. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cognitive impairment
KW  - morphological brain abnormalities
KW  - chronic schizophrenia
KW  - 1980
KW  - Brain
KW  - Brain Disorders
KW  - Cognitive Impairment
KW  - Morphology
KW  - Schizophrenia
KW  - 1980
DO  - 10.1097/00005053-198005000-00011
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - FLIER, JEFFREY
AU  - EDWARDS, MICHAEL W.
AU  - DALY, JOHN W.
AU  - MYERS, CHARLES W.
T1  - Widespread Occurrence in Frogs and Toads of Skin Compounds Interacting with the Ouabain Site of Na+,K+-ATPase.
JO  - Science
JF  - Science
Y1  - 1980/05/02/
VL  - 208
IS  - 4443
M3  - Article
SP  - 503
EP  - 505
SN  - 00368075
AB  - Amphibians of the family Bufonidae contain high levels of skin compounds that both inhibit Na+- and K+-dependent adenosinetriphosphatase and antagonize the binding of ouabain to the enzyme. In species of Bufo and Atelopus, these compounds are relatively nonpolar bufodienolides, whereas Dendrophryniscus and Melanophryniscus contain more polar compounds of unknown structure. Skin extracts from 30 of 48 species of frogs representing an additional eight families contained relatively low levels of compounds that inhibit binding of ouabain to Na+,K+-adenosinetriphosphatase. The widespread occurrence of low levels of inhibitory compounds is consonant with the role for these compounds as physiological regulators of Na+,K+-adenosinetriphosphatase in amphibian skin; high levels in the Bufonidae probably also serve as a defense against some predators. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159224; FLIER, JEFFREY 1; EDWARDS, MICHAEL W. 2; DALY, JOHN W. 2; MYERS, CHARLES W. 3; Affiliations: 1: Beth Israel Hospital, Boston, Massachusetts 02215; 2: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Herpetology, American Museum of Natural History, New York 10024; Issue Info: 5/ 2/1980, Vol. 208 Issue 4443, p503; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HUBERT, HELEN B.
AU  - FABSITZ, RICHARD R.
AU  - FEINLEIB, MANNING
AU  - BROWN, KENNETH S.
T1  - Olfactory Sensitivity in Humans: Genetic Versus Environmental Control.
JO  - Science
JF  - Science
Y1  - 1980/05/09/
VL  - 208
IS  - 4444
M3  - Article
SP  - 607
EP  - 609
SN  - 00368075
AB  - Olfactory sensitivity to acetic acid, isobutyric acid, and 2-sec-butyl-cyclohexanone was tested in 97 adult male twin pairs to determine the extent to which variation in odor perception was genetically determined. Analysis of the data revealed no evidence for heritability of olfactory sensitivity. However, factors significantly associated with odor perception included cigar, pipe, and cigarette smoking; body fatness; alcohol consumption; and diabetes mellitus [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159262; HUBERT, HELEN B. 1; FABSITZ, RICHARD R. 1; FEINLEIB, MANNING 1; BROWN, KENNETH S. 2; Affiliations: 1: Epidemiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda 20205; Issue Info: 5/ 9/1980, Vol. 208 Issue 4444, p607; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROBIE-SUH, K.
AU  - ROBINSON, R.
AU  - GELBOIN, H. V.
AU  - GUENGERICH, F. PETER
T1  - Aryl Hydrocarbon Hydroxylase Is Inhibited by Antibody to Rat Liver Cytochrome P-450.
JO  - Science
JF  - Science
Y1  - 1980/05/30/
VL  - 208
IS  - 4447
M3  - Article
SP  - 1031
EP  - 1033
SN  - 00368075
AB  - Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159379; ROBIE-SUH, K. 1; ROBINSON, R. 1; GELBOIN, H. V. 1; GUENGERICH, F. PETER 2; Affiliations: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Biochemistry and Center in Environmental Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232; Issue Info: 5/30/1980, Vol. 208 Issue 4447, p1031; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - MACDONALD, JOHN F.
T1  - Picrotoxin Convulsions Involve Synaptic and Nonsynaptic Mechanisms on Cultured Mouse Spinal Neurons.
JO  - Science
JF  - Science
Y1  - 1980/05/30/
VL  - 208
IS  - 4447
M3  - Article
SP  - 1054
EP  - 1056
SN  - 00368075
AB  - The cellular mechanisms underlying picrotoxin-induced convulsive activity were studied by using mouse spinal neurons growing in tissue culture. Picrotoxin-induced convulsive activity in most but not all of the cells studied. The activity could be inverted by polarizing to positive potentials and eliminated either by decreasing the ratio of calcium to magnesium or by applying tetrodotoxin. When applied locally to individual cells, picrotoxin lowered spike threshold and induced spontaneous firing in some but not all cells tested. The results suggest that picrotoxin-induced convulsive activity involves rapidly summating synaptic activity which may be evoked by high-frequency repetitive firing. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85159390; BARKER, JEFFERY L. 1; MACDONALD, JOHN F. 2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; 2: Helen Scott Playfair Neuroscience Unit, University of Toronto, Toronto Western Hospital, Toronto, Canada; Issue Info: 5/30/1980, Vol. 208 Issue 4447, p1054; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KLOWDEN, MARC J.
AU  - BEACH, RAYMOND
T1  - Large Doses of Ecdysterone May Inhibit Mosquito Behavior Nonspecifically.
JO  - Science
JF  - Science
Y1  - 1980/05/30/
VL  - 208
IS  - 4447
M3  - Article
SP  - 1062
EP  - 1063
SN  - 00368075
N1  - Accession Number: 85159394; KLOWDEN, MARC J. 1; BEACH, RAYMOND 2; Affiliations: 1: Department of Entomology, University of Georgia, Athens 30602; 2: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Issue Info: 5/30/1980, Vol. 208 Issue 4447, p1062; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hall, R. P.
AU  - Lawley, T. J.
AU  - Heck, J. A.
AU  - Katz, S. I.
T1  - IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schonlein purpura, systemic lupus erythematosus and other diseases.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/06//
VL  - 40
IS  - 3
M3  - Article
SP  - 431
EP  - 437
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The sera of patients with dermatitis herpetifomis. Henoch-Schönlein purpura and systemic lupus erythematosus were examined for IgA-containing immune complexes using a newly described radioimmunoassay. The IgG Raji cell radioimmunoassay and the 125I-Clq binding assay were also used to detect IgG-and IgM-containing soluble immune complexes, IgA-containing immune complexes were found in the sera of twelve of forty-nine (24%) patients with dermatitis herpetiformis, four of six (67%) patients with Henoch-Schönlein purpura, and seven of ten (70%) patients with systemic lupus erythematosus. IgG-or IgM-containing immune complexes were also found in six of forty-seven patients with dermatitis herpetifomis, in one of six patients with Henoch-Schönlein purpura, and in nine of ten patients with systemic lupus erythematosus, by either the 125I-Clq binding assay or the IgG Raji cell assay. The finding of soluble IgA immune complexes in a high percentage of patients with systemic lupus erythematosus and Henoch-Schönlein purpura suggests that they may play an important role in the pathogenesis of these diseases. In contrast, their low prevalence in patients with dermatitis herpetifomis suggests that IgA-containing immune complexes may not play a major role in the pathogenesis of dermatitis herpetiformis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN diseases
KW  - SYSTEMIC lupus erythematosus
KW  - IMMUNOGLOBULINS
KW  - IMMUNOGLOBULIN G
KW  - BLOOD plasma
KW  - VASCULAR diseases
N1  - Accession Number: 18001181; Hall, R. P. 1 Lawley, T. J. 1 Heck, J. A. 1 Katz, S. I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA.; Source Info: Jun1980, Vol. 40 Issue 3, p431; Subject Term: SKIN diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOGLOBULIN G; Subject Term: BLOOD plasma; Subject Term: VASCULAR diseases; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Noronha-Blob, Lalita
AU  - Huang, Shih-Wen
T1  - An in vitro assay for uni-directional migration inhibition employing 5lCr-labelled macrophages.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/06//
VL  - 40
IS  - 3
M3  - Article
SP  - 627
EP  - 632
PB  - Wiley-Blackwell
SN  - 00099104
AB  - An improved in vitro technique to assay for migration inhibitory factor is presented. The method employs chromium-51-radiolabelled guinea-pig macrophages and offers significant advantages including (1) elimination of observer to observer variation and tedious measurements resulting in an objective and technically simple assay, (2) the requirement for small numbers of immune lymphocytes, (3) good sensitivity and reproducibility between successive assays performed on different days. and (4) a means of obtaining relative estimates of the 'strength' (concentration) of the factor so that comparisons with healthy individuals can be made. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KILLER cells
KW  - CHROMIUM group
KW  - LEUCOCYTES
KW  - SWINE
KW  - MACROPHAGES
KW  - LYMPHOCYTES
N1  - Accession Number: 18002097; Noronha-Blob, Lalita 1 Huang, Shih-Wen 2; Affiliation:  1: Gerontology Research Center, National Institute of Aging, NIH, Baltimore City Hospitals, University of Maryland School of Medicine, Baltimore, Maryland, USA.  2: Division of Pediatric Allergy and Immunology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Source Info: Jun1980, Vol. 40 Issue 3, p627; Subject Term: KILLER cells; Subject Term: CHROMIUM group; Subject Term: LEUCOCYTES; Subject Term: SWINE; Subject Term: MACROPHAGES; Subject Term: LYMPHOCYTES; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Olson, Lucy
AU  - Liebow, Elliot
AU  - Mannino, Fortune V.
AU  - Shore, Milton F.
T1  - Runaway Children Twelve Years Later.
JO  - Journal of Family Issues
JF  - Journal of Family Issues
Y1  - 1980/06//
VL  - 1
IS  - 2
M3  - Article
SP  - 165
EP  - 188
SN  - 0192513X
AB  - THIS is a 12-year follow-up pilot study of 14 youths who ran away from home in the mid-1960s. The study is based on 44 intensive interviews with the former runaways, their nonrunaway siblings, their parents, and other relatives. Four major questions were addressed. Marked differences in outcomes were found (a) between runaways and their siblings; (b) between runaway repeaters and nonrepeaters, and (c) between runaways from working-class backgrounds and those from middle-class backgrounds. In general, whatever their other statuses, children who ran away more than once showed increasing personal and social dysfunction as young adults. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RUNAWAY children
KW  - SOCIAL background
KW  - HOMELESS children
KW  - MISSING persons
KW  - PARENT & child
KW  - FAMILIES
N1  - Accession Number: 13543708; Olson, Lucy 1; Liebow, Elliot 2; Mannino, Fortune V. 3; Shore, Milton F. 4; Source Information: Jun1980, Vol. 1 Issue 2, p165; Subject: RUNAWAY children; Subject: SOCIAL background; Subject: HOMELESS children; Subject: MISSING persons; Subject: PARENT & child; Subject: FAMILIES; Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Neifeld, James P.
AU  - Lippman, Marc E.
T1  - Steroid Hormone Receptors and Melanoma.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/06//
VL  - 74
IS  - 6
M3  - Article
SP  - 379
EP  - 381
SN  - 0022202X
AB  - This article focuses on the relationship between steroid hormone receptors and melanomas. Different classes of steroid hormones are thought to exert their specific effects on cells through similar mechanisms. Cell membranes are freely permeable to steroid hormones. Once inside the cell the steroid binds to an intracellular protein. The receptor-steroid complex then undergoes a temperature dependent activation step, which permits nuclear translocation and presumed binding to specific nuclear sites. Transcription of specific DNA segments ensues with apparent regulation at least at the level of the primary mRNA transcript.
KW  - STEROID receptors
KW  - MELANOMA
KW  - CELL membranes
KW  - PROTEIN binding
KW  - DNA
KW  - MESSENGER RNA
N1  - Accession Number: 12544454; Neifeld, James P. 1 Lippman, Marc E. 2; Affiliation:  1: Division of Surgical Oncology and MCV- VCU Cancer Center, Medical College of Virginia, Richmond, Virginia.  2: Medical Breast Cancer Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jun80, Vol. 74 Issue 6, p379; Subject Term: STEROID receptors; Subject Term: MELANOMA; Subject Term: CELL membranes; Subject Term: PROTEIN binding; Subject Term: DNA; Subject Term: MESSENGER RNA; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12544454
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2004-20770-011
AN  - 2004-20770-011
AU  - Patrick, Clifford H.
T1  - Health and Migration of the Elderly.
JF  - Research on Aging
JO  - Research on Aging
JA  - Res Aging
Y1  - 1980/06//
VL  - 2
IS  - 2
SP  - 233
EP  - 241
CY  - US
PB  - Sage Publications
SN  - 0164-0275
SN  - 1552-7573
N1  - Accession Number: 2004-20770-011. Partial author list: First Author & Affiliation: Patrick, Clifford H.; Epidemiology, Demography, and Biometry Program, National Institute on Aging, NIH, US. Release Date: 20050110. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Health; Human Migration; Long Term Care. Minor Descriptor: Nursing Homes; Retirement. Classification: Gerontology (2860); Social Structure & Organization (2910). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). References Available: Y. Page Count: 9. Issue Publication Date: Jun, 1980. 
AB  - The degree to which migration decisions of the elderly are influenced by health status is largely unknown. Two seemingly contradictory influences of health on migration are possible within the older cohort. First, those elderly in good health would appear more likely to make discretionary moves, such as to retirement homes in the Sunbelt, than elderly who are in poor health. Alternatively, those elderly in declining health, such as stroke victims, seem more likely to be involved in a move to a long-term care facility. While both types of migration related to health occur, the size of the first relative to the second and the distance of the moves of each type need to be determined. Both types of health-related migration have policy implications which are briefly addressed in this article. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - health status
KW  - migration
KW  - elderly people
KW  - retirement homes
KW  - long-term care
KW  - 1980
KW  - Aging
KW  - Health
KW  - Human Migration
KW  - Long Term Care
KW  - Nursing Homes
KW  - Retirement
KW  - 1980
DO  - 10.1177/016402758022011
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Goldman, Robert C.
AU  - Leive, Loretta
T1  - Heterogeneity of Antigenic-Side-Chain Length in Lipopolysaccharide from <em>Escherichia coli</em> 0111 and <em>Salmonella typhimurium</em> LT2.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/06/12/
VL  - 107
IS  - 1
M3  - Article
SP  - 145
EP  - 153
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Lipopolysaccharide from Escherichia coli 0111, its galE derivative when grown in galactose, E. coli 086, and Salmonella typhimurium LT2 all contain antigenic side chains and separate into more than 40 components by electrophoresis in gradients of polyacrylamide containing sodium dodecylsulfate. These components from E. coli 0111 are not interconvertible and show a heterogeneous size distribution when fractionated with Sephadex G-200. Isoelectric focusing of this mixture in pH 3.5–10 ampholines reveals a single component, ruling out extensive charge heterogeneity. The relative antigenic side chain lengths for the components, estimated using ratios of galactose in antigenic side chain to phosphate in the lipid-A—core oligosaccharide region, show that the size heterogeneity is due to differences in the number of antigenic side chain units per molecule and ranges from none to over 40. Preference for molecules of specific chain lengths, especially short ones, was observed. In contrast, the gale mutant grown without galactose does not synthesize antigenic side chains, and more than 90% of its lipopolysaccharide migrates as a single band at a position corresponding to the lowest-molecular-weight component from the above preparations. Lipopolysaccharide from E. coli PL2, a K12 strain lacking antigenic side chain, separates into two low-molecular-weight components on electrophoresis. These results confirm that the heterogeneity which we observe in lipopolysaccharide containing antigenic side chains, is due to the side chain rather than the lipid-A—core oligosaccharide region. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDOTOXINS
KW  - ESCHERICHIA coli
KW  - GALACTOSE
KW  - SALMONELLA typhimurium
KW  - POLYACRYLAMIDE
KW  - GRAM-negative bacteria
N1  - Accession Number: 13491740; Goldman, Robert C. 1 Leive, Loretta 1; Affiliation:  1: Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda; Source Info: 6/12/80, Vol. 107 Issue 1, p145; Subject Term: ENDOTOXINS; Subject Term: ESCHERICHIA coli; Subject Term: GALACTOSE; Subject Term: SALMONELLA typhimurium; Subject Term: POLYACRYLAMIDE; Subject Term: GRAM-negative bacteria; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GOOSEY, JOHN D.
AU  - ZIGLER JR., J. SAMUEL
AU  - KINOSHITA, JIN H.
T1  - Cross-Linking of Lens Crystallins in a Photodynamic System: A Process Mediated by Singlet Oxygen.
JO  - Science
JF  - Science
Y1  - 1980/06/13/
VL  - 208
IS  - 4449
M3  - Article
SP  - 1278
EP  - 1280
SN  - 00368075
AB  - In a dye-sensitized photooxidation system, lens crystallin polypeptides become cross-linked, and a bluefluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437680; GOOSEY, JOHN D. 1; ZIGLER JR., J. SAMUEL 1; KINOSHITA, JIN H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 6/13/1980, Vol. 208 Issue 4449, p1278; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GOLDENBERG, DAVID M.
AU  - KIM, EDMUND E.
AU  - DELAND, FRANK H.
AU  - VAN NAGELL Jr., JOHN R.
AU  - JAVADPOUR, NASSER
T1  - Clinical Radioimmunodetection of Cancer with Radioactive Antibodies to Human Chorionic Gonadotropin.
JO  - Science
JF  - Science
Y1  - 1980/06/13/
VL  - 208
IS  - 4449
M3  - Article
SP  - 1284
EP  - 1286
SN  - 00368075
AB  - Injection of iodine-131 -labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumorlnontumor ratio of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85437683; GOLDENBERG, DAVID M. 1,2; KIM, EDMUND E. 3,4; DELAND, FRANK H. 3,4; VAN NAGELL Jr., JOHN R. 5; JAVADPOUR, NASSER 6; Affiliations: 1: Division of Experimental Pathology, Department of Pathology, University of Kentucky, Lexington 40536; 2: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Division of Nuclear Medicine, Department of Radiation Medicine, University of Kentucky; 4: Veterans Administration Medical Center, Lexington, Kentucky 40536; 5: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Medical Center; 6: Surgery Branch, National Cancer Institute, National Institutes of Health; Issue Info: 6/13/1980, Vol. 208 Issue 4449, p1284; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DALY, JOHN W.
AU  - MYERS, CHARLES W.
AU  - WARNICK, JORDAN E.
AU  - ALBUQUERQUE, EDSON X.
T1  - Levels-of Batrachotoxin and Lack of Sensitivity to Its Action in Poison-Dart Frogs (Phyllobates).
JO  - Science
JF  - Science
Y1  - 1980/06/20/
VL  - 208
IS  - 4450
M3  - Article
SP  - 1383
EP  - 1385
SN  - 00368075
N1  - Accession Number: 85196138; DALY, JOHN W. 1; MYERS, CHARLES W. 2; WARNICK, JORDAN E. 3; ALBUQUERQUE, EDSON X. 3; Affiliations: 1: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Herpetology, American Museum of Natural History, New York 10024; 3: Department of Pharmacology and Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201; Issue Info: 6/20/1980, Vol. 208 Issue 4450, p1383; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Gollapudi, Sastry V. S.
AU  - Kern, Milton
T1  - Lipid A Induces cells, Uniquely Present in Bone Marrow, to Secrete Proteins other than Immunoglobulins.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/07//7/1/80
VL  - 108
IS  - 1
M3  - Article
SP  - 233
EP  - 237
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The lipid-A moiety of lipopolysaccharide induced freshly isolated bone marrow cells incubated with radioactive leucine to exhibit enhanced release of proteins other than immunoglobulins. Such stimulation by lipopolysaccharide was essentially not observed with cell suspensions from spleen, thymus, appendix, peritoneal exudate, whole blood, lymph node, liver, testis, buffy coat of blood and reticulocyte-enriched blood. The extracellular appearance of proteins was shown to be due to secretion by excluding other alternatives. Thus, the rate of cell death and/or leakage of cellular contents, as well as the rate of shedding of surface membrane protein, was unaffected measurably by lipopolysaccharide. Secretion of non-immunoglobulin proteins was selective as judged by the finding that the rate of immunoglobulin released by bone marrow cells during the usual four-hour pulse-label period was not stimulated by lipopolysaccharide. Enhancement of mitogenesis and enhancement of secretion of non-immunoglobulin protein by lipopolysaccharide appeared to occur at independent sites or even in different ceils because splenocytes which readily exhibited mitogenic response to lipopolysaccharide essentially did not exhibit stimulation of secretion of non-immunoglobulin protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BONE marrow cells
KW  - SECRETION
KW  - PROTEINS
KW  - IMMUNOGLOBULINS
KW  - LIPIDS
KW  - LEUCINE
KW  - CELL suspensions
N1  - Accession Number: 13606669; Gollapudi, Sastry V. S. 1 Kern, Milton 1; Affiliation:  1: National Institutes of Arthritis, Metabolism and Digestive Diseases National Institutes of Health, Bethesda; Source Info: 7/1/80, Vol. 108 Issue 1, p233; Subject Term: BONE marrow cells; Subject Term: SECRETION; Subject Term: PROTEINS; Subject Term: IMMUNOGLOBULINS; Subject Term: LIPIDS; Subject Term: LEUCINE; Subject Term: CELL suspensions; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tamaki, Kunihiko
AU  - Katz, Stephen I.
T1  - Ontogeny of Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/07//
VL  - 75
IS  - 1
M3  - Article
SP  - 12
EP  - 13
SN  - 0022202X
AB  - Results of transplantation and chimera studies indicate that epidermal Langerhans cells are derived from precursor cells originating in bone marrow. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ONTOGENY
KW  - EMBRYOLOGY
KW  - BIOLOGY
KW  - LANGERHANS cells
KW  - DENDRITIC cells
KW  - BONE marrow
N1  - Accession Number: 12521037; Tamaki, Kunihiko 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul80, Vol. 75 Issue 1, p12; Subject Term: ONTOGENY; Subject Term: EMBRYOLOGY; Subject Term: BIOLOGY; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: BONE marrow; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12521037
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Green, Ira
AU  - Stingl, Georg
AU  - Shevach, Ethan M.
AU  - Katz, Stephen I.
T1  - Antigen Presentation and Allogeneic Stimulation by Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/07//
VL  - 75
IS  - 1
M3  - Article
SP  - 44
EP  - 45
SN  - 0022202X
AB  - Isolated Langerhans cells were studied for 2 immunologic functions, the ability to present antigen to sensitized T lymphocytes and the ability to act as stimulator cells for mixed lymphocyte reactions. Langerhans cells can perform both of these functions. This fact, with the previous finding that Langerhans cells possess surface la antigens and Fe and C3 receptors, strongly suggests that Langerhans cells act as epidermal macrophages. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGEN presenting cells
KW  - LANGERHANS cells
KW  - IMMUNOGLOBULINS
KW  - LYMPHOCYTES
KW  - CELL physiology
KW  - IA antigens
KW  - CELL receptors
N1  - Accession Number: 12521102; Green, Ira 1 Stingl, Georg 2 Shevach, Ethan M. 3 Katz, Stephen I. 4; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy, Bethesda, Maryland.  2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland.  3: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.  4: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul80, Vol. 75 Issue 1, p44; Subject Term: ANTIGEN presenting cells; Subject Term: LANGERHANS cells; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: CELL physiology; Subject Term: IA antigens; Subject Term: CELL receptors; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12521102
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2011-11212-001
AN  - 2011-11212-001
AU  - Cowan, Jonathan D.
AU  - Kay, David C.
AU  - Neidert, Gary L.
AU  - Ross, Frances E.
AU  - Belmore, Susan M.
T1  - Defeated and Joyless: Potential measures of change in drug abuser characteristics.
JF  - Journal of Nervous and Mental Disease
JO  - Journal of Nervous and Mental Disease
JA  - J Nerv Ment Dis
Y1  - 1980/07//
VL  - 168
IS  - 7
SP  - 391
EP  - 399
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0022-3018
SN  - 1539-736X
AD  - Kay, David C., National Institute on Drug Abuse Addiction Research Center, P. O. Box 12390, Lexington, KY, US, 40583
N1  - Accession Number: 2011-11212-001. PMID: 7400787 Partial author list: First Author & Affiliation: Cowan, Jonathan D.; National Institute on Drug Abuse, Division of Research, Addiction Research Center, US. Release Date: 20110704. Correction Date: 20140915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Addiction; Emotional States; Questionnaires; Self-Concept; Test Construction. Minor Descriptor: Alcoholism; Opiates; Test Validity. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Lack of Confidence Scale; Unpopularity Scale; Low Energy Scale; Joyless Scale [Appended]; Defeated Scale [Appended]; Profile of Mood States; Present Affect Rating; Maturity Scale; California Personality Inventory; Social Experience Questionnaire DOI: 10.1037/t10619-000; Minnesota Multiphasic Personality Inventory; Addiction Research Center Inventory. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 1980. 
AB  - Defeated and Joyless scales were developed from a questionnaire given to 54 normal, 53 alcoholic, and 28 opiate addict subjects. The Defeated scale differentiates the alcoholics and addicts from normals but not from each other, whereas the Joyless scale differentiates addicts from both alcoholics and normals. When shown to 48 college students, a film about poverty increased the Joyless score, as well as other measures, but had little effect on the Defeated score. These scales appear to distinguish between self-concept (Defeated) and mood (Joyless) components of hypophoria, an affective disorder hypothesized to be associated with drug abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Defeated scale
KW  - Joyless scale
KW  - test development
KW  - alcoholism
KW  - opiate addiction
KW  - discriminative validity
KW  - hypophoria
KW  - drug abuse
KW  - 1980
KW  - Addiction
KW  - Emotional States
KW  - Questionnaires
KW  - Self-Concept
KW  - Test Construction
KW  - Alcoholism
KW  - Opiates
KW  - Test Validity
KW  - 1980
DO  - 10.1097/00005053-198007000-00001
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06560-053
AN  - 2006-06560-053
AU  - Woolf, Bertie H.
T1  - And a Time for Dying.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1980/07//
VL  - 25
IS  - 7
SP  - 574
EP  - 575
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06560-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Woolf, Bertie H.; Division of Research Grants, National Institutes of Health (NIH), Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Death and Dying; Mental Disorders; Psychiatric Patients. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Wendkos, Martin H. Sudden Death and Psychiatric Illness=New York: SP Medical & Scientific Books, 1979. Pp. 349. $20.00; 1979. Page Count: 2. Issue Publication Date: Jul, 1980. 
AB  - Reviews the book, Sudden Death and Psychiatric Illness by Martin H. Wendkos (1979). This volume presents an overview of nonsuicidal sudden death syndromes, with special reference to unexpected deaths in psychiatric patients. Case histories and clinical and epidemiological studies are examined and reexamined in the search for risk factors. The health professional who deals with psychiatric patients will find this book interesting. The book's message is clear--the whole picture must always be considered, including the patient's current physical and mental status, the possibility of drug interaction or overdose, the effect of depression, and so forth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric patients
KW  - sudden death syndromes
KW  - mental status
KW  - psychiatric illness
KW  - 1980
KW  - Death and Dying
KW  - Mental Disorders
KW  - Psychiatric Patients
KW  - 1980
U2  - Wendkos, Martin H. (1979); Sudden Death and Psychiatric Illness; New York: SP Medical & Scientific Books, 1979. Pp. 349. $20.00
DO  - 10.1037/018189
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - HELD, JOE R.
AU  - SEILING, ELEANOR
T1  - Animals in the Lab.
JO  - Science
JF  - Science
Y1  - 1980/07/11/
VL  - 209
IS  - 4453
M3  - Article
SP  - 214
EP  - 214
SN  - 00368075
N1  - Accession Number: 85196201; HELD, JOE R. 1; SEILING, ELEANOR 2; Affiliations: 1: Division of Research Services, National Institutes of Health, Bethesda, Maryland, 20205; 2: United Action for Animals, Inc., 205 East 42 Street, New York, 10017; Issue Info: 7/11/1980, Vol. 209 Issue 4453, p214; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KAKUNAGA, TAKEO
AU  - CROW, JANET D.
T1  - Cell Variants Showing Differential Susceptibility to Ultraviolet Light-Induced Transformation.
JO  - Science
JF  - Science
Y1  - 1980/07/25/
VL  - 209
IS  - 4455
M3  - Article
SP  - 505
EP  - 507
SN  - 00368075
AB  - Six variant clones isolated from a subclone of BALB13T3-A31 clone were classified into three groups according to their different susceptibilities to cell transformation by ultraviolet light irradiation: highly susceptible, intermediately susceptible, and resistant. All variant clones showed similar susceptibility to cytotoxic effects induced by ultraviolet light. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85196321; KAKUNAGA, TAKEO 1; CROW, JANET D. 1; Affiliations: 1: Cell Genetics Section, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 7/25/1980, Vol. 209 Issue 4455, p505; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MATHERS, DAVID A.
AU  - BARKER, JEFFERY L.
T1  - (-)Pentobarbital Opens Ion Channels of Long Duration in Cultured Mouse Spinal Neurons.
JO  - Science
JF  - Science
Y1  - 1980/07/25/
VL  - 209
IS  - 4455
M3  - Article
SP  - 507
EP  - 509
SN  - 00368075
AB  - Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to γ-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by γ-aminobutyric acid. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85196322; MATHERS, DAVID A. 1; BARKER, JEFFERY L. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20205; Issue Info: 7/25/1980, Vol. 209 Issue 4455, p507; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Garcia-Palmieri, Mario R.
AU  - Sorlie, Paul
AU  - Tillotson, Jeanne
AU  - Costas, Jr., Raul
AU  - Cordero, Edna
AU  - Rodriguez, Maresa
T1  - Relationship of dietary intake to subsequent coronary heart disease incidence: The Puerto Rico Heart Health Program.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1980/08//
VL  - 33
IS  - 8
M3  - Article
SP  - 1818
EP  - 1827
SN  - 00029165
AB  - A study of base-line nutrient intakes of 8218 urban and rural Puerto Rican men aged 45 to 64 years was undertaken in relation to subsequent six year coronary heart disease (CHD) incidence. Urban dietary intakes were significantly higher in total fat and lower in carbohydrate, particularly starch. Average cholesterol intakes were 83 mg/day higher in urban than rural men. Urban serum cholesterol values were significantly higher than rural values. -Urban men who developed myocardial infarction or CHD death had significantly lower calorie and carbohydrate intakes, i.e., chiefly those derived from rice and legumes. The same association was found in the rural group but failed to reach statistical significance. A very low intake of alcohol was noted in the 73 rural CHD cases. Dietary sucrose intake showed no relationship to CHD incidence. Multivariate analysis, taking relative weight, hematocrit, blood pressure, serum cholesterol, alcohol intake, cigarette smoking, area, and age into account, demonstrated an independent inverse relation of carbohydrate intake from legumes to CHD incidence. The apparent protective effect of complex carbohydrate merits further investigation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 94366696; Garcia-Palmieri, Mario R. 1; Sorlie, Paul 2; Tillotson, Jeanne 3; Costas, Jr., Raul 4; Cordero, Edna 5; Rodriguez, Maresa 5; Affiliations: 1: Director, Puerto Rico Heart Health Program, and Professor and Head, Department of Medicine, University of Puerto Rico; 2: Statistician, Division of Heart and Vascular Diseases, Biometrics Research Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland; 3: Nutritionist, Clinical Applications and Prevention Program, Division of Heart and Vascular Diseases; National Heart, Lung, and Blood Institute, Bethesda, Maryland; 4: Associate Director, Puerto Rico Heart Health Program and Professor, Departmetn of Medicine, University of Puerto Rico; 5: Dietitian, Puerto Rico Heart Health Program, University of Puerto Rico; Issue Info: Aug1980, Vol. 33 Issue 8, p1818; Number of Pages: 10p; Illustrations: 9 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Blot, William J.
T1  - Changing Patterns of Breast Cancer among American Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/08//
VL  - 70
IS  - 8
M3  - Article
SP  - 832
EP  - 835
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Although overall mortality from breast cancer has changed little over time in the United States, age-specific rates showed distinctive patterns during 1950-75, with declines among premenopausal women, a rise then fall among perimenopausal women, and level then increasing rates among postmenopausal women. The trends appear related to the changing patterns of childbearing among young adult women over the first two-thirds of this century, The national mortality and birth data presented are consistent with existing analytic evidence of a protective influence upon breast cancer of early first birth, and suggest that the protection may be expressed at all ages above 30. (Am J Public Health 1980: 70:833-836.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BREAST cancer
KW  - MORTALITY
KW  - MENOPAUSE
KW  - CHILDBIRTH
KW  - WOMEN -- Diseases
KW  - CANCER in women
KW  - AGE groups
KW  - AGE differences
KW  - RISK factors
KW  - UNITED States
N1  - Accession Number: 4952129; Blot, William J. 1; Affiliation:  1: Head, Analytical Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20205; Source Info: Aug1980, Vol. 70 Issue 8, p832; Subject Term: BREAST cancer; Subject Term: MORTALITY; Subject Term: MENOPAUSE; Subject Term: CHILDBIRTH; Subject Term: WOMEN -- Diseases; Subject Term: CANCER in women; Subject Term: AGE groups; Subject Term: AGE differences; Subject Term: RISK factors; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ida, S.
AU  - Hooks, J. J.
AU  - Siraganian, R. P.
AU  - Notkins, A.L.
T1  - Enhancement of IgE-mediated histamine release from human basophils by immune-specific lymphokines.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/08//
VL  - 41
IS  - 2
M3  - Article
SP  - 380
EP  - 387
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Human leucocytes (basophils) release histamine when exposed to ragweed antigen E or anti-IgE. The present study shows that when leucocytes from BCG-positive donors are first incubated with PPD and then challenged with anti-IgE, histamine release is enhanced. In contrast, when leucocytes from BCG-negative donors are incubated with PPD and then challenged with anti-IgE there is no enhancement of histamine release. The enhancement of histamine release was detected within 24 hr after addition of PPD, but was maximal at 48 to 72 hr. Supernatant fluids collected from these leucocyte cultures revealed the presence o f a soluble mediator(s) which, when incubated with leucocytes from BCG-negative donors, enhanced the release of histamine. Examination of the supernatant fluids from BCG-positive leucocyte cultures stimulated with PPD showed a correlation between histamine-release enhancing activity and interferon. Treatment of the culture fluids at pH 2.0 abolished the anti-viral activity, indicating that the interferon was of the type II or 'immune' class. The same treatment only partly abolished the histamine-release enhancing activity. It is concluded that immune-specific stimulation of leucocytes results in the release of soluble mediators that are capable of enhancing IgE-mediated histamine release. [ABSTRACT FROM AUTHOR]
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KW  - INFLAMMATION -- Mediators
KW  - HISTAMINE
KW  - ANTIHISTAMINES
KW  - LEUCOCYTES
KW  - FLUID mechanics
KW  - CYTOKINES
N1  - Accession Number: 15985168; Ida, S. 1 Hooks, J. J. 1 Siraganian, R. P. 2 Notkins, A.L. 1; Affiliation:  1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.  2: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Aug1980, Vol. 41 Issue 2, p380; Subject Term: INFLAMMATION -- Mediators; Subject Term: HISTAMINE; Subject Term: ANTIHISTAMINES; Subject Term: LEUCOCYTES; Subject Term: FLUID mechanics; Subject Term: CYTOKINES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Horowitz, Alice M.
AU  - Suomi, John D.
AU  - Peterson, John K.
AU  - Mathews, Barbara L.
AU  - Voglesong, Ronald H.
AU  - Lyman, Beverly A.
T1  - Effects of supervised daily dental plaque removal by children after 3 years.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1980/08//
VL  - 8
IS  - 4
M3  - Article
SP  - 171
EP  - 176
SN  - 03015661
AB  - The benefits of a school-based plaque removal program arc presented. Children in grades 5-8 were included in a study which was designed to determine the effect on oral hygiene, gingival inflammation and dental caries of removing dental plaque through supervised daily flossing and toothbrushing in school. A fluoride-free dentifrice was used. Controls did not receive instruction in plaque removal procedures nor did they engage in plaque removal activities at school. For three school years the students in the treatment group practiced daily plaque removal, supervised by trained personnel. All participants were examined initially for plaque (PHP), gingival inflammation (DHC) and dental caries (DMFS). Girls in the treatment group showed a significant reduction (28%) in mean plaque scores and, for girls and boys, the mean changes in gingivitis scores were significantly reduced (40% and 17%, respectively). Adjusted mean incremental DMF surface scores were 13% lower in the treatment group than in the control group. The difference between groups was not statistically significant and was accounted for entirely by the findings in mesial and distal surfaces (26%). This difference approached statistical significance (P= 0.07). [ABSTRACT FROM AUTHOR]
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KW  - GINGIVITIS
KW  - GUM disease
KW  - DENTAL caries
KW  - ORAL hygiene
KW  - DENTAL plaque
KW  - DENTISTRY
KW  - dental caries
KW  - flossing
KW  - gingivitis
KW  - oral hygiene
KW  - plaque removal
KW  - toothbrushing.
N1  - Accession Number: 12057589; Horowitz, Alice M. 1 Suomi, John D. 2 Peterson, John K. 3 Mathews, Barbara L. 4 Voglesong, Ronald H. 4 Lyman, Beverly A. 4; Affiliation:  1: National Caries Program, National Institute of Dental Research, National Institutes of Health, U. S. Department of Health, Education and Welfare, Bethesda, Maryland.  2: Dental Affairs Staff Office of Assistant Secretary for Health, PHS U. S. Department of Health, Education and Welfare, Rockville, Maryland.  3: Division of Denial Health, .North Dakota Slate Department of Health, Bismarck, North Dakota.  4: Section of Dental Health, Connecticut Slate Department of Health, Hartford, Connecticut, U.S.A.; Source Info: Aug1980, Vol. 8 Issue 4, p171; Subject Term: GINGIVITIS; Subject Term: GUM disease; Subject Term: DENTAL caries; Subject Term: ORAL hygiene; Subject Term: DENTAL plaque; Subject Term: DENTISTRY; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: flossing; Author-Supplied Keyword: gingivitis; Author-Supplied Keyword: oral hygiene; Author-Supplied Keyword: plaque removal; Author-Supplied Keyword: toothbrushing.; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12057589
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Horowitz, Herschel S.
AU  - Heifetz, Stanley B.
AU  - Meyers, Rhea J.
AU  - Driscoll, William S.
AU  - Shou-Hua Li, William S.
T1  - A program of self-administered fluorides in a rural school system.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1980/08//
VL  - 8
IS  - 4
M3  - Article
SP  - 177
EP  - 183
SN  - 03015661
AB  - In 1972, a self-administered fluoride program was initiated in Nelson County, VA, a fluoride-deficient area. Children in elementary school (grades K-6) ingest daily a 1-mg fluoride tablet, rinse weekly with 0.2% NaF solution and receive fluoride dentifrice for home use. In 1978, dental examinations of elementary schoolchildren (ages 6-12) who had continuously participated in the program for 1 to 6 years showed a prevalence of 2.70 DMFS, 45% lower than the score of 4.89 DMFS for their cohorts at the baseline. The preventive program inhibited dental caries effectively in all types of surfaces, but the reduction in proximal surfaces of 85% is particularly striking. Findings of high school children (ages 13-17) in 1978, who had not participated in the elementary school program for 1-5 years, showed evidence of strong post-treatment effects. At cacti succeeding follow-up survey, benefits have continued to improve. For elementary school participants, benefits were 17.7% after 2 years, 35.3% after 4 years and 44.8% after 6 years. Weekly fluoride mouthrinsing and daily ingestion of a fluoride tablet are feasible school-based procedures for the prevention of dental caries. Combined with the use of a fluoride dentifrice at home, these procedures have a pronounced cariostatic effect. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL caries -- Prevention
KW  - PREVENTIVE dentistry
KW  - TEETH -- Care & hygiene
KW  - SCHOOL children
KW  - FLUORIDES
KW  - FLUORINE compounds
KW  - dental caries prevention
KW  - fluorides
KW  - school health.
N1  - Accession Number: 12057862; Horowitz, Herschel S. 1 Heifetz, Stanley B. 1 Meyers, Rhea J. 1 Driscoll, William S. 1 Shou-Hua Li, William S. 1; Affiliation:  1: National Caries Program, national Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug1980, Vol. 8 Issue 4, p177; Subject Term: DENTAL caries -- Prevention; Subject Term: PREVENTIVE dentistry; Subject Term: TEETH -- Care & hygiene; Subject Term: SCHOOL children; Subject Term: FLUORIDES; Subject Term: FLUORINE compounds; Author-Supplied Keyword: dental caries prevention; Author-Supplied Keyword: fluorides; Author-Supplied Keyword: school health.; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1600-0528.ep12057862
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bonner, William M.
AU  - West, Michael H. P.
AU  - Stedman, John D.
T1  - Two-Dimensional Gel Analysis of Histones in Acid Extracts of Nuclei, Cells, and Tissues.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/08//8/1/80
VL  - 109
IS  - 1
M3  - Article
SP  - 17
EP  - 23
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Two-dimensional gel analysis of histones from extracts of nuclei, cells, and tissues is described. A discontinuous buffer system which concentrates the sample was used to increase resolution in both dimensions and also to allow the direct loading of HCl extracts of chromatin, nuclei, cells, and tissues. Stained one-dimensional gels are used as sample gels for the second dimension, cetyltrimethylammonium bromide being used to solubilize the proteins in the dye-protein complex. These methods enable one to purify proteins through acetic acid/urea/Triton, acetic acid/urea, and sodium dodecyl sulfate gels without eluting them from the gels. The method is also compatible with the use of protamine to displace histones from nuclei and nucleosomes separated in chromatin gels. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTONES
KW  - PROTEINS
KW  - CHROMATIN
KW  - GEL electrophoresis
KW  - MOLECULAR pharmacology
KW  - BIOCHEMISTRY
N1  - Accession Number: 13608616; Bonner, William M. 1 West, Michael H. P. 1 Stedman, John D. 1; Affiliation:  1: Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda; Source Info: 8/1/80, Vol. 109 Issue 1, p17; Subject Term: HISTONES; Subject Term: PROTEINS; Subject Term: CHROMATIN; Subject Term: GEL electrophoresis; Subject Term: MOLECULAR pharmacology; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kano, Itsu
AU  - Nebert, Daniel W.
T1  - Subcellular Localization of Membrane-Bound Aryl-Hydrocarbon Hydroxylase and NAD(P)H-Dependent Reductase Activities in Mouse Liver.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/08//8/1/80
VL  - 109
IS  - 1
M3  - Article
SP  - 25
EP  - 31
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The subcellular distribution of aryl-hydrocarbon hydroxylase, NADPH-cytochrome c reductase, NADH :cytochrome c reductase, and NADH :cytochrome b5 reductase activities in mouse liver was studied using the biochemical membrane markers microsomal glucose-6-phosphatase, mitochondrial cytochrome c oxidase, and plasma membrane 5′-nucleotidase. The rate of appearance of activity of 3-methylcholanthrene-induced aryl-hydrocarbon hydroxylase in the microsomes of C57BL/6N mice is more than twice as rapid as that in the nuclear envelope. The nuclear fraction contains less than 1% of the total cellular activities of the hydroxylase and all three reductases. All detectable basal activity of aryl-hydrocarbon hydroxylase in the nuclear fraction of control C57BL/6N and DBA′2N and 3-methylcholanthrene-treated DBA/2N mice and all detectable activities of NADPH :cytochrome c, NADH :cytochrome c, and NADH :catochrome b5 reductase in the nuclear fraction of control and 3-methylcholanthrene-treated C57BL/6N and DBA/2N mice can be completely accounted for by the degree of microsomal fragment contamination (as assessed by the microsomal marker glucose-6-phosphatase). These data raise doubts about certain previous reports of ‘nuclear’ enzyme activities in which microsomal contamination was not taken into account. However, there is more induced activity of aryl-hydrocarbon hydroxylase in the nuclear fraction of 3-methylcholanthrene-treated C57BL/6N mice than can be accounted for by the degree of microsomal membrane contribution. The routine Ah locus is known to regulate the induction by certain polycyclic aromatic chemicals of numerous drug-metabolizing enzyme activities such as aryl-hydrocarbon hydroxylase associated with cytochrome P1-450. The expression of 3-methylcholanthrene-inducible hydroxylase in nuclear membranes, like that in microsomal membranes, thus appears to be controlled by the Ah regulatory gene. [ABSTRACT FROM AUTHOR]
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KW  - ENZYMES
KW  - CYTOCHROME P-450
KW  - MICROSOMES
KW  - SUBCELLULAR fractionation
KW  - DEVELOPMENTAL pharmacology
KW  - BIOCHEMISTRY
KW  - ARYL hydrocarbon hydroxylases
N1  - Accession Number: 13608900; Kano, Itsu 1 Nebert, Daniel W. 1; Affiliation:  1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: 8/1/80, Vol. 109 Issue 1, p25; Subject Term: ENZYMES; Subject Term: CYTOCHROME P-450; Subject Term: MICROSOMES; Subject Term: SUBCELLULAR fractionation; Subject Term: DEVELOPMENTAL pharmacology; Subject Term: BIOCHEMISTRY; Subject Term: ARYL hydrocarbon hydroxylases; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hawley-Nelson, Pamela
AU  - Sullivan, James E.
AU  - Kung, Margaret
AU  - Hennings, Henry
AU  - Yuspa, Stuart H.
T1  - Optimized Conditions for the Growth of Human Epidermal Cells in Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/08//
VL  - 75
IS  - 2
M3  - Article
SP  - 176
EP  - 182
SN  - 0022202X
AB  - Methods have been optimized for the isolation, growth and passage of differentiating human epidermal cells in dispersed cell culture. Human neonatal foreskin epidermis was separated from dermis after floating the skin on trypsin. Keratinocytes were isolated by dissociation of epidermal sheets in calcium, magnesium-free phosphate buffered saline. Under culture conditions established for mouse keratinocytes, human epidermal cells retained epithelial morphology for 1-2 mo and could be subcultured 2-3 times. Cells exposed to modified culture conditions were tested for growth at low cell density and ability to be repeatedly subcultured while maintaining normal epithelial morphology. Optimal conditions were determined by counting the number of colonies formed 1-3 weeks after plating 0.2-1 × 104 cells/cm² and by measuring the maximum number of passages attainable with cultures plated at 105 cells/cm². Compared to tissue culture plastic, a substrate of collagen (prepared by acid extraction of rat tail tendons) increased colony formation 2-4 fold. Lowering the culture temperature from 37° to 34° or 31°C reduced colony number to 50% and 10% respectively. Serum concentrations of 10-20% yielded 2- 4 fold more colonies than lower or higher levels. Seven commercial or especially formulated media did not enhance either growth parameter. Both colony formation and number of passages were increased at pH 7.0-7.2 compared to lower or higher pH. Medium ionic calcium concentrations of 0.3-0.4 mM doubled the number of colonies and passages compared to higher or lower levels. These improvements in culture conditions enhance the suitability of human keratinocyte cultures for a number of biological studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - CELL culture
KW  - TRYPSIN
KW  - EPITHELIUM
KW  - KERATINOCYTES
KW  - MORPHOLOGY
N1  - Accession Number: 12522602; Hawley-Nelson, Pamela 1 Sullivan, James E. 1 Kung, Margaret 1 Hennings, Henry 2 Yuspa, Stuart H. 2; Affiliation:  1: Microbiological Associates, Bethesda, Maryland.  2: Vitro Pathogenesis Section, Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A..; Source Info: Aug80, Vol. 75 Issue 2, p176; Subject Term: EPIDERMIS; Subject Term: CELL culture; Subject Term: TRYPSIN; Subject Term: EPITHELIUM; Subject Term: KERATINOCYTES; Subject Term: MORPHOLOGY; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12522602
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Hawley-Nelson, Pamela
AU  - Poirier, Miriam
AU  - Katz, Stephen I.
AU  - Yuspa, Stuart H.
T1  - Detection of Pemphigoid Antigen, Pemphigus Antigen, and Keratin Filaments by Indirect Immunofluorescence in Cultured Human Epidermal Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/08//
VL  - 75
IS  - 2
M3  - Article
SP  - 183
EP  - 186
SN  - 0022202X
AB  - In order to determine whether pemphigold antigen is synthesized by epidermal cells, and whether other, normal keratinocyte, antigens are synthesized in culture, primary cultures and subsequent subcultures of human epidermal cells derived from neonatal foreskins were studied for the presence of pemphigoid antigen, pemphigus antigen and keratin filaments using indirect immunofluorescence. Twenty-four hr after plating primary cultures, pemphigoid antigen was detected as an asymmetric fluorescence on the cell membranes of rounded cells or a faint fluorescence of the cytoplasm of cells which had spread on the substrate. At later times in primary cultures and in subcultures pemphigoid antigen showed a pattern of coarsely granular fluorescence within or under the cytoplasm of many of the small cells at both the base and expanding periphery of epidermal cell colonies. Pemphigus antigen was detected mainly on the cell membranes of the larger flat cells located more superficially in the colonies. Keratin filaments were detected in cells at all levels of the epidermal colonies. Rounded cells, which had not yet spread on the substrate, displayed bright perinuclear fluorescence with keratin antibody. In cells spread on the substrate, keratin filaments often appeared to line up end-to-end with filaments of neighboring cells. No qualitative changes in fluorescence of any of these antigens could be detected through 6 subcultures. Human fibroblasts in culture did not display any of these three antigens by immunofluorescence. The finding that cultured human epidermal cells displayed these antigens with the same pattern and intensity through 6 passages indicates that pemphigoid antigen, as well as pemphigus antigen and keratin, were newly synthesized in culture. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - FORESKIN
KW  - IMMUNOFLUORESCENCE
KW  - PEMPHIGUS
KW  - KERATIN
KW  - CYTOPLASM
N1  - Accession Number: 12522615; Stanley, John R. 1,2 Hawley-Nelson, Pamela 3 Poirier, Miriam 4 Katz, Stephen I. 1 Yuspa, Stuart H. 4; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Laboratory of Developmental Biology, Anomalies, National Institute of Dental Research, Bethesda, Maryland, U.S.A.  3: Microbiology Associates, Bethesda, Maryland, U.S.A.  4: Vitro Pathogenesis Section, Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug80, Vol. 75 Issue 2, p183; Subject Term: ANTIGENS; Subject Term: FORESKIN; Subject Term: IMMUNOFLUORESCENCE; Subject Term: PEMPHIGUS; Subject Term: KERATIN; Subject Term: CYTOPLASM; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12522615
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DB  - aph
ER  - 

TY  - GEN
AU  - Robertson, W Davenport
T1  - A user-oriented approach to setting priorities for library services
JO  - Special Libraries
JF  - Special Libraries
Y1  - 1980/08//
VL  - 71
IS  - 8
M3  - Article
SP  - 345
EP  - 353
SN  - 00386723
AB  - A user-oriented model for setting priorities for services in the medium size sci/tech research library is described. A survey of the research staffs of three organizations as to their conception of library priorities is compared with the budgets and opinions of the three library directors. The survey results are consistent and show much agreement with the librarians. The model groups eleven aspects of library services into three clusters of importance with journal purchases and computerized literature searching given the highest priority. This model can be used for planning and evaluating special libraries
N1  - Accession Number: ISTA1502555; Robertson, W Davenport 1; Affiliations: 1 : Library And Information Services, National Institute Of Environmental Health Sciences, Research Triangle Park, Nc;  Source Info: August 1980, Vol. 71 Issue 8, p345; Note: Update Code: 1500; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - SHAFIE, SAMIR M.
T1  - Estrogen and the Growth of Breast Cancer: New Evidence Suggests Indirect Action.
JO  - Science
JF  - Science
Y1  - 1980/08/08/
VL  - 209
IS  - 4457
M3  - Article
SP  - 701
EP  - 702
SN  - 00368075
AB  - The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures there from have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85196409; SHAFIE, SAMIR M. 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 8/ 8/1980, Vol. 209 Issue 4457, p701; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - KALIN, NED H.
AU  - RISCH, SAMUEL C.
AU  - COHEN, ROBERT M.
AU  - INSEL, THOMAS
AU  - MURPHY, DENNIS L.
T1  - Dexamethasone Fails to Suppress β-Endorphin Plasma Concentrations in Humans and Rhesus Monkeys.
JO  - Science
JF  - Science
Y1  - 1980/08/15/
VL  - 209
IS  - 4458
M3  - Article
SP  - 827
EP  - 828
SN  - 00368075
AB  - In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating β-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary β-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate β-endorphin secretion in the same way. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85196457; KALIN, NED H. 1; RISCH, SAMUEL C. 1; COHEN, ROBERT M. 1; INSEL, THOMAS 1; MURPHY, DENNIS L. 1; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 8/15/1980, Vol. 209 Issue 4458, p827; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Boice, John D.
AU  - Fraumeni Jr., Joseph F.
T1  - Late Effects following Isoniazid Therapy.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/09//
VL  - 70
IS  - 9
M3  - Article
SP  - 987
EP  - 989
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Among 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide INH) for pulmonary tuberculosis no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1.090 patients who did not receive INH partly due to radiogenic breast cancer resulting from multiple chest flouroscopics to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ISONIAZID
KW  - DRUGS -- Side effects
KW  - TUBERCULOSIS -- Treatment
KW  - WOMEN -- Diseases -- Treatment
KW  - ANTITUBERCULAR agents
KW  - CIRRHOSIS of the liver
KW  - ISONICOTINIC acid
KW  - HYDRAZINE
KW  - LIVER diseases
N1  - Accession Number: 4957375; Boice, John D. 1 Fraumeni Jr., Joseph F. 1; Affiliation:  1: Environmental Epidemiology Branch, National Cancer Institute; Source Info: Sep90, Vol. 70 Issue 9, p987; Subject Term: ISONIAZID; Subject Term: DRUGS -- Side effects; Subject Term: TUBERCULOSIS -- Treatment; Subject Term: WOMEN -- Diseases -- Treatment; Subject Term: ANTITUBERCULAR agents; Subject Term: CIRRHOSIS of the liver; Subject Term: ISONICOTINIC acid; Subject Term: HYDRAZINE; Subject Term: LIVER diseases; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Nakamura, K.
T1  - Conversion of immune response patterns from high to low and low to high by an RNase-sensitive thymocyte extract.
JO  - Immunology
JF  - Immunology
Y1  - 1980/09//
VL  - 41
IS  - 1
M3  - Article
SP  - 25
EP  - 35
PB  - Wiley-Blackwell
SN  - 00192805
AB  - In vitro immune responses to human serum albumin (HSA) and synthetic polypeptides (T,G)-A-L, and (H,G)-A L, associated with the maturation IgG-forming plasma cells were studied in relation to thymic low molecular weight RNA. This RNA, from normal low-responder animals to these antigens, converted high-responder bone marrow cells to low responders, whereas RNA from high responders converted low-responder bone marrow cells to high responders. These changes of immune response patterns were observed not only in the combination of allogeneic mouse cells and RNA, but also in xenogeneic rat and mouse systems. Thymic RNA from low-responder animals had no suppressive activity to high-responder RNA, when both were added together to one dish with antigen. High doses (⊗50) of low-responder thymic RNA stimulated the same immune response level as a regular amount of high-responder thymic RNA. Intact thymocytes derived from low-responder mice added together with high-responder thymic RNA did not suppress immune response of high-responder bone marrow cultures. Intact allogeneic thymocytes also induced the same response as allogeneic thymic RNA. These results indicate that humoral immune responses can be influenced by thymic RNA derived from normal animals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOLOGY
KW  - IMMUNE system
KW  - IMMUNE response
KW  - BONE marrow
KW  - PLASMA cells
KW  - RNA
N1  - Accession Number: 13971206; Nakamura, K. 1,2; Affiliation:  1: Immunology Branch, Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Molecular Biology Laboratory, Department of Biochemistry, Kilasato University School of Medicine, 1-15-1, Kilasato, Sagamihara, Kanagawa, Japan 228; Source Info: Sep80, Vol. 41 Issue 1, p25; Subject Term: IMMUNOLOGY; Subject Term: IMMUNE system; Subject Term: IMMUNE response; Subject Term: BONE marrow; Subject Term: PLASMA cells; Subject Term: RNA; Number of Pages: 11p; Illustrations: 6 Diagrams; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Lee, C. J.
T1  - Maternal-foetal interaction, antibody formation, and metabolic response in mice immunized with pneumococcal polysaccharides.
JO  - Immunology
JF  - Immunology
Y1  - 1980/09//
VL  - 41
IS  - 1
M3  - Article
SP  - 45
EP  - 54
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The maternal transfer of pneumococcal polysaccharides to foetus, as well as the antibody formation and metabolic response were studied in mice exposed to pneumococcal polysaccharides during pregnancy. Type 19 and type 57 pneumococcal polysaccharides display cross-placental transfer to foetus. These polysaccharides also transfer through mother's milk to neonates. Maternal immunization of type 19 polysaccharide during pregnancy induced higher antibody formation in the offspring than the group from non-immunized mothers. Young mice, which received a second dose of polysaccharide at 2 weeks of age, showed a higher antibody response than those which did not receive polysaccharide. Treatment of mothers with anti-lymphocyte serum, following by administration of polysaccharide, significantly increased the neonatal immune response to the polysaccharide. Treatment of the mother with a high dose of type 19 or type 57 polysaccharide did not cause significant changes in neonatal growth and organ weights. The offspring from mothers treated with high doses of these polysaccharides did not exhibit abnormalities in chemical contents of their tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOLOGY
KW  - MICE
KW  - METABOLISM
KW  - IMMUNOGLOBULINS
KW  - PNEUMOCOCCAL vaccine
KW  - POLYSACCHARIDES
N1  - Accession Number: 13971224; Lee, C. J. 1; Affiliation:  1: Bureau of Biologics, National Institutes of Health, Bethesda, Maryland U.S.A.; Source Info: Sep80, Vol. 41 Issue 1, p45; Subject Term: IMMUNOLOGY; Subject Term: MICE; Subject Term: METABOLISM; Subject Term: IMMUNOGLOBULINS; Subject Term: PNEUMOCOCCAL vaccine; Subject Term: POLYSACCHARIDES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wei, L. J.
T1  - A Generalized Gehan and Gilbert Test for Paired Observations That Are Subject to Arbitrary Right Censorship.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1980/09//
VL  - 75
IS  - 371
M3  - Article
SP  - 634
SN  - 01621459
AB  - An asymptotically distribution-free test, along the line of Gehan (1965) and Gilbert (1962), for paired observations that are subject to arbitrary right censorship is proposed. This test is shown to be more powerful than the sign test under a bivariate exponential model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - NONPARAMETRIC statistics
KW  - STATISTICAL reliability
KW  - PROBABILITY theory
KW  - STANDARD deviations
KW  - STATISTICAL hypothesis testing
KW  - ASYMPTOTIC distribution (Probability theory)
KW  - CHARACTERISTIC functions
KW  - Asymptotically distribution-free test
KW  - Bivariate exponential model
KW  - Gehan and Gilbert test
KW  - Right censorship.
N1  - Accession Number: 4600355; Wei, L. J. 1; Affiliations: 1: National Cancer Institute, 5C09 Landow Bldg., Bethesda, MD 20205.; Issue Info: Sep80, Vol. 75 Issue 371, p634; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: STATISTICAL reliability; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STANDARD deviations; Thesaurus Term: STATISTICAL hypothesis testing; Subject Term: ASYMPTOTIC distribution (Probability theory); Subject Term: CHARACTERISTIC functions; Author-Supplied Keyword: Asymptotically distribution-free test; Author-Supplied Keyword: Bivariate exponential model; Author-Supplied Keyword: Gehan and Gilbert test; Author-Supplied Keyword: Right censorship.; Number of Pages: 4p; Document Type: Article
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DB  - buh
ER  - 

TY  - JOUR
AU  - Halperin, Max
AU  - Ware, James H.
AU  - Wu, Margaret
T1  - Conditional Distribution-Free Tests for the Two-Sample Problem in the Presence of Right Censoring.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1980/09//
VL  - 75
IS  - 371
M3  - Article
SP  - 638
SN  - 01621459
AB  - Two-sample rank tests for survival data in the presence of arbitrary right censoring are considered. We distinguish between administrative censoring, arising because survival study participants do not enter as a cohort, and censoring due to "loss to follow-up." We show how conditionally distribution-free tests can be constructed in certain situations. Conditional versions of the generalized Wilcoxon and Mantel statistics are shown to be asymptotically normal in the conditional reference set, but with modified means and variances. Efficiency of these tests relative to asymptotically distribution-free competitors is unity, providing the censoring distributions are discrete, the same for both samples, and providing loss-to-follow-up (LFU) distributions are the same for the two samples. When these assumptions do not hold, efficiency can deteriorate considerably, being poorest, other things being equal, when the censoring distribution is continuous. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NONPARAMETRIC statistics
KW  - ANALYSIS of variance
KW  - DISTRIBUTION (Probability theory)
KW  - STATISTICS
KW  - PROBABILITY theory
KW  - SURVIVAL analysis (Biometry)
KW  - FAILURE time data analysis
KW  - ASYMPTOTIC distribution (Probability theory)
KW  - BIOMETRY
KW  - Censoring
KW  - Distribution free.
KW  - Mantel-Haenszel test
KW  - Survival analysis
KW  - Two-sample problem
KW  - Wilcoxon test
N1  - Accession Number: 4600390; Halperin, Max 1; Ware, James H. 2; Wu, Margaret 3; Affiliations: 1: Research Professor, Department of Statistics, George Washington University, Bethesda, MD 20014.; 2: Associate Professor, Department of Biostatistics, Harvard University, Boston, MA 02115.; 3: Mathematical Statistician, Mathematical and Applied Statistics Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20205.; Issue Info: Sep80, Vol. 75 Issue 371, p638; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: SURVIVAL analysis (Biometry); Subject Term: FAILURE time data analysis; Subject Term: ASYMPTOTIC distribution (Probability theory); Subject Term: BIOMETRY; Author-Supplied Keyword: Censoring; Author-Supplied Keyword: Distribution free.; Author-Supplied Keyword: Mantel-Haenszel test; Author-Supplied Keyword: Survival analysis; Author-Supplied Keyword: Two-sample problem; Author-Supplied Keyword: Wilcoxon test; Number of Pages: 8p; Document Type: Article
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DB  - buh
ER  - 

TY  - JOUR
AU  - Hirata, Fusao
AU  - Axelrod, Julius
T1  - Phospholipid Methylation and Biological Signal Transmission.
JO  - Science
JF  - Science
Y1  - 1980/09/05/
VL  - 209
IS  - 4461
M3  - Article
SP  - 1082
EP  - 1090
SN  - 00368075
N1  - Accession Number: 85196563; Hirata, Fusao 1; Axelrod, Julius; Affiliations: 1: Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 9/ 5/1980, Vol. 209 Issue 4461, p1082; Number of Pages: 9p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Land, Charles E.
T1  - Estimating Cancer Risks from Low Doses of Ionizing Radiation.
JO  - Science
JF  - Science
Y1  - 1980/09/12/
VL  - 209
IS  - 4462
M3  - Article
SP  - 1197
EP  - 1203
SN  - 00368075
N1  - Accession Number: 85266533; Land, Charles E. 1; Affiliations: 1: Health Statistician, Environmental Epidemiology Branch of National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 9/12/1980, Vol. 209 Issue 4462, p1197; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SINGER, MAXINE
T1  - Recombinant DNA Revisited.
JO  - Science
JF  - Science
Y1  - 1980/09/19/
VL  - 209
IS  - 4463
M3  - Article
SP  - 1318
EP  - 1318
SN  - 00368075
N1  - Accession Number: 85196608; SINGER, MAXINE 1; Affiliations: 1: Chief, Laboratory of Biochemistry, National Cancer Institute, Bethesda, A&ryland 20205; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1318; Number of Pages: 2/3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Leder, Philip
AU  - Hansen, J. Norman
AU  - Konkel, David
AU  - Leder, Aya
AU  - Nishioka, Yutaka
AU  - Talkington, Carol
T1  - Mouse Globin System: A Functional and Evolutionary Analysis.
JO  - Science
JF  - Science
Y1  - 1980/09/19/
VL  - 209
IS  - 4463
M3  - Article
SP  - 1336
EP  - 1342
SN  - 00368075
N1  - Accession Number: 85196612; Leder, Philip 1; Hansen, J. Norman 1; Konkel, David 1; Leder, Aya 1; Nishioka, Yutaka 1; Talkington, Carol 1; Affiliations: 1: Investigators, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1336; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Liu, Chih-Ping
AU  - Tucker, Philip W.
AU  - Mushinski, J. Frederic
AU  - Blattner, Frederick R.
T1  - Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D.
JO  - Science
JF  - Science
Y1  - 1980/09/19/
VL  - 209
IS  - 4463
M3  - Article
SP  - 1348
EP  - 1353
SN  - 00368075
N1  - Accession Number: 85196614; Liu, Chih-Ping 1; Tucker, Philip W. 2,3; Mushinski, J. Frederic 4; Blattner, Frederick R. 5; Affiliations: 1: Postdoctoral Fellow in Laboratory of Genetics, University of Wisconsin-Madison, Madison 53706; 2: Assistant Professor, Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216; 3: Associate Professor, Department of Microbiology, University of Texas Southwestern Medical School, Dallas 75235.; 4: Senior Investigator, Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 5: Associate Professor of Genetics, Laboratory of Genetics, University of Wisconsin- Madison, Madison 53706; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1348; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Tucker, Philip W.
AU  - Liu, Chih-Ping
AU  - Mushinski, J. Frederic
AU  - Blattner, Frederick R.
T1  - Mouse Immunoglobulin D: Messenger RNA and Genomic DNA Sequences.
JO  - Science
JF  - Science
Y1  - 1980/09/19/
VL  - 209
IS  - 4463
M3  - Article
SP  - 1353
EP  - 1360
SN  - 00368075
N1  - Accession Number: 85196615; Tucker, Philip W. 1; Liu, Chih-Ping 2; Mushinski, J. Frederic 3; Blattner, Frederick R. 4; Affiliations: 1: Assistant Professor, Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216; 2: Postdoctoral Fellow, Laboratory of Genetics, University of Wisconsin-Madison, Madison 53706; 3: Senior Investigator, Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 4: Associate Professor of Genetics, Laboratory of Genetics, University of Wisconsin- Madison, Madison 53706; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1353; Number of Pages: 8p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - RISCH, SAMUEL C.
AU  - COHEN, ROBERT M.
AU  - JANOWSKY, DAVID S.
AU  - KALIN, NED H.
AU  - MURPHY, DENNIS L.
T1  - Mood and Behavioral Effects of Physostigmine on Humans Are Accompanied by Elevations in Plasma, β-Endorphin and Cortisol.
JO  - Science
JF  - Science
Y1  - 1980/09/26/
VL  - 209
IS  - 4464
M3  - Article
SP  - 1545
EP  - 1546
SN  - 00368075
AB  - Administration of physostigmine to normal volunteers produced significant elevations in plasma cortisol and β-endorphin immunoreactivity as well as alterations in mood, cognition, and behavior. These observations might be explained by a cholinergically mediated stress syndrome. However, peak elevations in plasma β- endorphin immunoreactivity (but not in plasma cortisol) were significantly correlated with physostigmine-induced increases in depression ratings. These results suggest that a cholinergically mediated, β-endorphin pathway may be involved in the observed affective changes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85196680; RISCH, SAMUEL C. 1; COHEN, ROBERT M. 1; JANOWSKY, DAVID S. 2; KALIN, NED H. 3; MURPHY, DENNIS L. 3; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla 92161; 3: Clinical Neuropharmacology Branch, National Institute of Mental Health; Issue Info: 9/26/1980, Vol. 209 Issue 4464, p1545; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Simpson, Ian Alexander
AU  - Pfeuffer, Thomas
T1  - Functional Desensitisation of β-Adrenergic Receptors of Avian Erythrocytes by Catecholamines and Adenosine 3', 5'-Phosphate.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/10//10/1/80
VL  - 111
IS  - 1
M3  - Article
SP  - 111
EP  - 116
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Prolonged exposure to β-adrenergic agonists of pigeon erythrocytes causes a reversible loss (70%) of catecholamine-stimulated adenylate cyclase activity without reduction in the number of β-adrenergic receptors. In addition a less pronounced decrease in non-stimulated and NaF-stimulated adenylate cyclase activity (15–22%) is observed, appearing at different agonist concentrations and at a different rate. Dibutyryladenosine 3′.5′-phosphate and the phosphodiesterase inhibitor methyl-isobutylxanthine partially mimick the action of the β-adrenergic agonist, thus pointing to a possible role of adenosine 3′,5′-phosphate in establishing desensitization. When adenylate cyclase from desensitized cells is stimulated with 5′-guanylyl-imidodiphosphate in the presence or absence of catecholamines the lag period preceding the attainment of maximal activity is extended. Likewise the rate of reversal by GTP or ATP of persistent activation of adenylate cyclase is slowed down. This is therefore interpreted to mean that the loss in hormonal stimulation on treatment of pigeon red blood cells with β-adrenergic agonists is due to a delayed exchange of GDP against GTP on the regulatory GTP-binding protein. Furthermore, we conclude that events causing the refractory state in avian erythrocytes should occur at a site distal to the β-adrenergic receptor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BETA adrenoceptors
KW  - ADRENERGIC receptors
KW  - ADENINE nucleotides
KW  - ADENOSINE
KW  - CATECHOLAMINES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13618034; Simpson, Ian Alexander 1 Pfeuffer, Thomas 2; Affiliation:  1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20014  2: Physiologisch-Chemisches Institut der Jtilius-Maximilians-Universität Würzburg, Koellikerstraße 2, D-8700 Würzburg, Federal Republic of Germany; Source Info: 10/1/80, Vol. 111 Issue 1, p111; Subject Term: BETA adrenoceptors; Subject Term: ADRENERGIC receptors; Subject Term: ADENINE nucleotides; Subject Term: ADENOSINE; Subject Term: CATECHOLAMINES; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lawley, Thomas J.
AU  - Gorevic, Peter D.
AU  - Hamburger, Max I.
AU  - Franklin, Edward C.
AU  - Frank, Michael M.
T1  - Multiple Types of Immune Complexes in Patients with Mixed Cryoglobulinemia.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1980/10//
VL  - 75
IS  - 4
M3  - Article
SP  - 297
EP  - 301
SN  - 0022202X
AB  - The sera of 13 patients with mixed cryoglobulinemia were examined for the presence of circulating immune complexes with the 125I-C1q binding assay before and after precipitation of cryoglobulins. All 13 patients had increased C1q binding activity(>10%) prior to cryoprecipitation (mean C1q binding activity =69%) and 10 of 13 had increased C1q binding activity after precipitation and removal of cryoglobulin (mean C1q binding activity = 41%). Decrements in serum C1q binding activity caused by cryoprecipitation ranged from minimal to marked (1-73%). Since all of these sera contained IgM rheumatoid factor, 7 were treated with 2-mercaptoethanol, known to dissociate 19S IgM into its subunits, and then tested for C1q binding activity and rheumatoid factor. 2-mercaptoethanol eliminated rheumatoid factor activity in all cases, but C1q binding activity remained elevated in 6 to 7 sera, thus indicating the presence of immune complexes distinct form 19S IgM rheumatoid factor complexes. By contrast absorption of 9 mixed cryoglobulinemia sera with solid-phase protein A resulted in the disappearance of immune complex-like material from the test sera, suggesting that IgG is a major constituent of the C1q binding material. Addition of eluate from the solid phase protein A to normal sera resulted in the appearance of increased C1q binding activity. Hepatitis B surface antigen was detected in the protein A eluate of two of six patient tested, and antibody to hepatitis B surface antigen was detected in the protein A eluate of a third patient. These findings indicate that in addition to cryoglobulins patients with mixed cryoglobulinemia have circulating immune complexes that are noncryoprecipitable. The immune complexes contain predominantly IgG and are, in most cases, distinct form 19S IgM rheumatoid factor complexes. In some cases the immune complexes may contain hepatitis B surface antigen or antibody. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CRYOGLOBULINEMIA
KW  - IMMUNE complexes
KW  - CRYOGLOBULINS
KW  - RHEUMATOID factor
KW  - PROTEIN binding
KW  - CELL surface antigens
N1  - Accession Number: 12530883; Lawley, Thomas J. 1 Gorevic, Peter D. 2 Hamburger, Max I. 3 Franklin, Edward C. 4 Frank, Michael M. 3; Affiliation:  1: Dermatology Branch, National Cancer Institute.  2: Department of Medicine State University of New York, Stony Brook, New York.  3: Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland.  4: New York University School of Medicine, New York, U.S.A..; Source Info: Oct80, Vol. 75 Issue 4, p297; Subject Term: CRYOGLOBULINEMIA; Subject Term: IMMUNE complexes; Subject Term: CRYOGLOBULINS; Subject Term: RHEUMATOID factor; Subject Term: PROTEIN binding; Subject Term: CELL surface antigens; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12530883
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thune, Elizabeth S.
AU  - Manderscheid, Ronald W.
AU  - Silbergeld, Sam
T1  - STATUS OR SEX ROLES AS DETERMINANTS OF INTERACTION PATTERNS IN SMALL, MIXED-SEX GROUPS.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1980/10//
VL  - 112
IS  - 1
M3  - Article
SP  - 51
PB  - Taylor & Francis Ltd
SN  - 00224545
N1  - Accession Number: 5388064; Thune, Elizabeth S. 1 Manderscheid, Ronald W. 1 Silbergeld, Sam 1; Affiliation:  1: Mental Health Study Center, National Institute of Mental Health, Adelphi, Maryland; Source Info: Oct1980, Vol. 112 Issue 1, p51; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-42218-028
AN  - 2013-42218-028
AU  - Curtz, Elizabeth
T1  - Review of Usable knowledge: Social science and social problem solving.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1980/10//
VL  - 50
IS  - 4
SP  - 744
EP  - 745
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42218-028. Partial author list: First Author & Affiliation: Curtz, Elizabeth; Mental Health Study Center, National Institute Of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Decision Making; Problem Solving; Social Issues; Social Sciences. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Lindblom, Charles E.; Cohen, David K. Usable knowledge: Social science and social problem solving=129 pp. $10.00 ($3.95 paper). Yale University Press, New Haven; 1979. Page Count: 2. Issue Publication Date: Oct, 1980. 
AB  - Reviews the book, Usable Knowledge: Social Science and Social Problem Solving by Charles E. Lindblom and David K. Cohen (1979). The authors argued that the production of usable knowledge through professional social inquiry (PSI) requires the reassessment of two fundamental assumptions. The problem which the authors pose for practitioners of professional social inquiry is how to use the tools and resources of social science to produce material appropriate and useful to varied decision-making processes. The book contains specific suggestion on how this Problem might be tackled and calls for a halt to the proliferation of social science research that addresses social problems without being tailored to fit the problem resolution process. This failure to write a book that is engaging and interesting to read may be unimportant. The authors dismiss as parochial and cosmetic the criticism that 'social scientists don't write attractively' Nonetheless is too often tme, and it makes Usable Knowledge a hook that is of importance to pPSI, but of little interest to other readers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - professional social inquiry
KW  - social science
KW  - social problem solving
KW  - decision making
KW  - 1980
KW  - Decision Making
KW  - Problem Solving
KW  - Social Issues
KW  - Social Sciences
KW  - 1980
U2  - Lindblom, Charles E.; Cohen, David K. (1979); Usable knowledge: Social science and social problem solving; 129 pp. $10.00 ($3.95 paper). Yale University Press, New Haven
DO  - 10.1037/h0098896
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - LIPSKY, JAMES J.
AU  - LAKE, C. R.
AU  - STERNBERG, D. E.
AU  - KAMMEN, D. P. VAN
AU  - BALLENGER, J. C.
AU  - ZIEGLER, M. G.
AU  - POST, R. M.
AU  - KOPIN, I. J.
AU  - BUNNEY, W. E.
T1  - Elevated Cerebrospinal Fluid Norepinephrine in Schizophrenics: Confounding Effects of Treatment Drugs.
JO  - Science
JF  - Science
Y1  - 1980/10/03/
VL  - 210
IS  - 4465
M3  - Article
SP  - 97
EP  - 97
SN  - 00368075
N1  - Accession Number: 85196745; LIPSKY, JAMES J. 1; LAKE, C. R. 2; STERNBERG, D. E. 3; KAMMEN, D. P. VAN 4; BALLENGER, J. C. 5; ZIEGLER, M. G. 6,7; POST, R. M. 8; KOPIN, I. J. 9; BUNNEY, W. E. 8; Affiliations: 1: Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 2: Department of Psychiatry and Pharmacology, Uniformed Services University, Health Sciences, Bethesda, Maryland 20014; 3: Department of Psychiatry, Yale University, New Haven, Connecticut 06519; 4: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 5: Department of Psychiatry, University of Virginia, Charlottesville 22903; 6: Department of Clinical Pharmacology, University of Texas Medical Branch, Galveston 77550; 7: Department of Medicine, University of Texas Medical Branch, Galveston 77550; 8: Biological Psychiatry Branch, National Institute of Mental Health; 9: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 10/ 3/1980, Vol. 210 Issue 4465, p97; Number of Pages: 3/4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SOTELO, J.
AU  - GIBBS JR., C. J.
AU  - GAJDUSEK, D. C.
T1  - Autoantibodies Against Axonal Neurofilaments in Patients with Kuru and Creutzfeldt-Jakob Disease.
JO  - Science
JF  - Science
Y1  - 1980/10/10/
VL  - 210
IS  - 4466
M3  - Article
SP  - 190
EP  - 193
SN  - 00368075
AB  - The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in high titer against a normal fibrillar protein within the axon of mature central neurons in culture. The morphological features of this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, and the partial characterization of the antibody are described. The detection of this hetero-specific autoantibody is thefirst evidence of an immune reaction in the spongiform encephalopathies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85266592; SOTELO, J. 1,2; GIBBS JR., C. J. 1; GAJDUSEK, D. C. 1; Affiliations: 1: Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; 2: Visiting Scientist, Instituto Nacional de Neurologia, Insurgentes Sur 3877, Mexico 22 D.F.; Issue Info: 10/10/1980, Vol. 210 Issue 4466, p190; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Picton, Colin
AU  - Klee, Claude B.
AU  - Cohen, Philip
T1  - Phosphorylase Kinase from Rabbit Skeletal Muscle: Identification of the Calmodulin-Binding Subunits.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1980/10/15/
VL  - 111
IS  - 2
M3  - Article
SP  - 553
EP  - 561
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Phosphorylase kinase has the structure (αβγδ)4 where the δ-subunit is identical to the calcium-binding protein termed calmodulin [Shenolikar et al. (1979) Eur. J. Biochem. 100, 329–337]. The β-subunit was tightly bound to phosphorylase kinase in the absence of calcium ions, and its rate of exchange with [14C]calmodulin was only 15% per week. The δ-subunit remained associated with phophorylase kinase in the presence of 8 M urea provided that calcium ions were present and this property enabled electrophoretic techniques to be used which demonstrated that the δ-subunit was associated with the γ-subunit. This finding was confirmed by cross-linking experiments with dimethylsuberimidate which resulted in the formation of a γδ complex. Phosphorylase kinase was shown to bind one additional molecule of calmodulin per αβγδ unit, termed the δ′-subunit. Glycerol gradient centrifugation in the presence of [14C]calmodulin indicated that the interaction of the δ′-subunit with phosphorylase kinase only occurred in the presence of calcium ions, and that the Kd value was near 0.01 μM. This was similar to the concentration of δ′-subunit which produced half-maximal activation. The δ′-subunit did not remain associated with phosphorylase kinase in the presence of 8 M urea, either in the presence or absence of calcium ions. The very slow exchange between the δ-subunit and [14C]calmodulin, and the calcium-dependent binding of the δ′-subunit allowed cross-linking experiments to be used which demonstrated that the δ′-subunit was bound to both the α and β subunits. This result was supported by the finding that selective proteolysis of either the α-subunit, or the α and β subunits, decreased or abolished the ability of phosphorylase kinase to bind to calmodulin-Sepharose. The roles of the different subunits in the regulation of phosphorylase kinase activity are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN kinases
KW  - CALCIUM-binding proteins
KW  - PROTEIN binding
KW  - CALMODULIN
KW  - PHOSPHORYLASES
KW  - CALCIUM ions
KW  - ELECTROPHORESIS
N1  - Accession Number: 13619336; Picton, Colin 1 Klee, Claude B. 2 Cohen, Philip 1; Affiliation:  1: Department of Biochemistry, University of Dundee, Medical Sciences Institute, Dundee, Great Britain, DD1 4HN  2: National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20014; Source Info: 10/15/80, Vol. 111 Issue 2, p553; Subject Term: PROTEIN kinases; Subject Term: CALCIUM-binding proteins; Subject Term: PROTEIN binding; Subject Term: CALMODULIN; Subject Term: PHOSPHORYLASES; Subject Term: CALCIUM ions; Subject Term: ELECTROPHORESIS; Number of Pages: 9p; Illustrations: 4 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Elin, Ronald J.
T1  - Instrumentation in Clinical Chemistry.
JO  - Science
JF  - Science
Y1  - 1980/10/17/
VL  - 210
IS  - 4467
M3  - Article
SP  - 286
EP  - 289
SN  - 00368075
N1  - Accession Number: 85361663; Elin, Ronald J. 1; Affiliations: 1: Clinical Chemistry Service, and chief, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/17/1980, Vol. 210 Issue 4467, p286; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - IWASA, KUNIHIKO
AU  - TASAKI, ICHIJI
AU  - GIBBONS, ROBERT C.
T1  - Swelling of Nerve Fibers Associated with Action Potentials.
JO  - Science
JF  - Science
Y1  - 1980/10/17/
VL  - 210
IS  - 4467
M3  - Article
SP  - 338
EP  - 339
SN  - 00368075
AB  - Swelling of nerve fibers during the action potential was demonstrated by three different methods. Generation of a propagated nerve impulse in a crab nerve produced an outward movement of 50 to 100 angstroms of the nerve surface and a rise in swelling pressure on the order of 5 dynes per square centimeter. In squid giant axons, the amplitude of the observed outward movement of the surface was small. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85361690; IWASA, KUNIHIKO 1,2; TASAKI, ICHIJI 1,2; GIBBONS, ROBERT C. 1,2; Affiliations: 1: Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 10/17/1980, Vol. 210 Issue 4467, p338; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VOUK, V. B.
T1  - Toxicology.
JO  - Science
JF  - Science
Y1  - 1980/10/24/
VL  - 210
IS  - 4468
M3  - Article
SP  - 418
EP  - 419
SN  - 00368075
N1  - Accession Number: 85266627; VOUK, V. B. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 10/24/1980, Vol. 210 Issue 4468, p418; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROTH, JAN J.
AU  - GERN, WILLIAM A.
AU  - ROTH, E. CAROL
AU  - RALPH, CHARLES L.
AU  - JACOBSON, ELLIOTT
T1  - Nonpineal Melatomn in the Alligator (Alligator mississippiensis).
JO  - Science
JF  - Science
Y1  - 1980/10/31/
VL  - 210
IS  - 4469
M3  - Article
SP  - 548
EP  - 550
SN  - 00368075
AB  - All living and most fossil representatives of the reptilian subclass Archosauria lack pineal bodies. Arrhythmic, low-level, nonpineal melatonin is present, however, in the blood of Alligator mississippiensis. Although pineal bodies have been implicated in circadian phenomena, these results suggest that arrhytmic melatonin in alligators may not be involved incircadian events and indicate that the pineal is not the only source of the hormone melatonin. The evolutionary loss of the pineal in Archosauria occurred during the Mesozoic, and era noted for its seasonal stability. Arrhythmic melatonin titers inalligators and pineal loss in alligators and other archosaurs may be related to Mesozoic seasonal stability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85266677; ROTH, JAN J. 1; GERN, WILLIAM A. 2; ROTH, E. CAROL 3; RALPH, CHARLES L. 4; JACOBSON, ELLIOTT 5; Affiliations: 1: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Zoology, University of Wyoming, Laramie 82071; 3: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health; 4: Department of Zoology and Entomology, Colorado State University, Fort Collins 80523; 5: Department of Laboratory Animal and Wildlife Medicine, College of Veterinary Medicine, J. Hillis Miller Health Center, University of Florida, Gainesville 32610; Issue Info: 10/31/1980, Vol. 210 Issue 4469, p548; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hare, J. A.
AU  - Ahmed, A.
AU  - Sell, K. W.
T1  - In vitro and in vivo response of lymphoid cells from LHC hamsters to murine thymus-independent and thymus-dependent antigens.
JO  - Immunology
JF  - Immunology
Y1  - 1980/11//
VL  - 41
IS  - 3
M3  - Article
SP  - 705
EP  - 714
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Lymphoid cell populations (spleen, lymph node, peripheral blood, thymus, and bone marrow) from LHC inbred hamsters were studied in order to characterize further the immune response of this species. The direct PFC response to several thymic-dependent or thymic-independent antigens was evaluated. A specific direct PFC response occurred 4 days after immunization with SRBC, DNP-BSA, DNP-lys-Ficoll, TNP-LPS, TNP-BA, and SSS-III. Attempts to induce a polyclonal antibody response with LPS, TNP-LPS, SSS-III, and DNP-lys-Ficoll were unsuccessful. A weak polyclonal response was induced with TNP-BA. Spleen cells and PBL responded strongly in vitro to the T-cell mitogens Con A and PHA-P, but gave weak at\d inconsistent responses to the B-cell mitogens LPS and PI-PC. LHC hamster lymphoid cell populations bore sIg and receptors for C3 (EAC rosettes) in approximately the same ratio as various murine species. However, the profile of the number of cells bearing low-to-intermediate densities of sIg differed significantly from those of murine species when analysed with the FACS. There was a sharp reduction in the number of cells with low-to-intermediate densities of sIg. These data suggest that B cells in this strain and species lack the ability to translate signals which lead to polyclonal antibody synthesis or lack the appropriate populations of B cells that have membrane receptors for mitogens which are thought to induce such activity in murine systems and provide evidence for separate signals that induce thymus-independent and mitogenic responses. The importance of this model for studying mechanisms involved in B-cell activation is discussed. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNE response
KW  - ANTIGENS
KW  - T cells
KW  - B cells
KW  - LYMPHOID tissue
KW  - THYMUS
N1  - Accession Number: 13988512; Hare, J. A. 1,2,3 Ahmed, A. 4 Sell, K. W. 1,2,3; Affiliation:  1: Department of Biology, Linfield College, McMinnville, Oregon  2: Department of Immunology, Naval Medical Research Institute, Bethesda, Maryland  3: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  4: Department of Immunology, Merck Institute for Therapeutic Research, P.O. Box 2000, Rahway, New Jersey 07065, U.S.A.; Source Info: Nov80, Vol. 41 Issue 3, p705; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: B cells; Subject Term: LYMPHOID tissue; Subject Term: THYMUS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hunter, Valerie A.
AU  - Knittel, M. D.
AU  - Fryer, J. L.
T1  - Stress-induced transmission of <em>Yersinia ruckeri</em> infection from carriers to recipient steelhead trout <em>Salmo gairdneri</em> Richardson.
JO  - Journal of Fish Diseases
JF  - Journal of Fish Diseases
Y1  - 1980/11//
VL  - 3
IS  - 6
M3  - Article
SP  - 467
EP  - 472
PB  - Wiley-Blackwell
SN  - 01407775
AB  - The transmission of Yersinia ruckeri has been investigated in steelhead trout using asymptomatic carriers of the causative bacterium of enteric redmouth disease. It was found that unstressed carrier fish did not transmit the bacterium to recipient fish to cause either an epizootic or produce new carrier fish, However, when the carriers were stressed with heat, the bacterium was transmitted from the carrier to recipient fish producing a lower intestinal carrier state but no deaths. Examination of experimentally infected fish to determine the number of carriers among the survivors indicated that the frequency varied as a function of time following infection. When immunized fish were challenged with Y. ruckeri they became temporary carriers of the bacterium for up to 3 days; but were not able to transmit the infection to healthy recipient fish. [ABSTRACT FROM AUTHOR]
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KW  - YERSINIA
KW  - TROUT
KW  - BACTERIA
KW  - CARRIER state (Communicable diseases)
KW  - COMMUNICABLE diseases in animals
KW  - DEATH
N1  - Accession Number: 15406467; Hunter, Valerie A. 1 Knittel, M. D. 2 Fryer, J. L. 3; Affiliation:  1: Laboratory of Molecular Biology, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U. S. A.  2: Environmental Protection Agency, Corvallis Environmental Research Laboratory Freshwater Division, Toxicology Branch, Corvallis, Oregon, U.S.A.  3: Department of Microbiology, Oregon State University, Corvallis, Oregon, U.S.A.; Source Info: Nov1980, Vol. 3 Issue 6, p467; Subject Term: YERSINIA; Subject Term: TROUT; Subject Term: BACTERIA; Subject Term: CARRIER state (Communicable diseases); Subject Term: COMMUNICABLE diseases in animals; Subject Term: DEATH; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Whitehead, William B.
T1  - Perception of Gastric Contractions and Self-Control of Gastric Motility.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1980/11//
VL  - 17
IS  - 6
M3  - Article
SP  - 552
EP  - 558
SN  - 00485772
AB  - The hypothesis was that self-control of a visceral response is dependent on ability to perceive occurrence of the response. Subjects were asked to judge whether or not a signal light coincided with a stomach contraction on each of approximately 200 trials. In a different session heart beat perception was tested by asking subjects to judge whether or not signal light flashes coincided with heart beats. Subjects then were tested for ability to increase and to decrease gastric motility prior to biofeedback training, after which half received 4 hrs of visual feedback while the others practiced without feedback. Control of motility without feedback was subsequently retested. Initially, subjects were unable to control gastric motility, but with feedback they could increase motility on command. Ability to perceive gastric contractions was unrelated to control of gastric motility before, during, or following biofeedback training, indicating that self-control of a visceral response is not dependent on perceptual sensitivity. Perception of stomach contractions correlated significantly (r = .51) with perception of heart beats, suggesting that there may be a generalized tendency to be aware of or to attend to visceral events. [ABSTRACT FROM AUTHOR]
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KW  - STOMACH -- Motility
KW  - SELF-control
KW  - VISCERAL reflex
KW  - HEART beat
KW  - BIOFEEDBACK training
KW  - Biofeedback.
KW  - Calibration theory
KW  - Gastric motility
KW  - Heart rate
KW  - Interoception
KW  - Stomach
KW  - Visceral perception
N1  - Accession Number: 11104296; Whitehead, William B. 1,2,3; Affiliation:  1: Department of Psychiatry, Johns Hopkins University School of Medicine.  2: Gerontology Research Center (Baltimore), National  Institute on Aging, National  Institute of Health, Education.  3: Welfare, Bethesda, and Baltimore City Hospitals, Baltimore.; Source Info: Nov1980, Vol. 17 Issue 6, p552; Subject Term: STOMACH -- Motility; Subject Term: SELF-control; Subject Term: VISCERAL reflex; Subject Term: HEART beat; Subject Term: BIOFEEDBACK training; Author-Supplied Keyword: Biofeedback.; Author-Supplied Keyword: Calibration theory; Author-Supplied Keyword: Gastric motility; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Interoception; Author-Supplied Keyword: Stomach; Author-Supplied Keyword: Visceral perception; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1469-8986.ep11104296
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SHINOHARA, TOSHIMICHI
AU  - PIATIGORSKY, JORAM
T1  - Persistence of Crystallin Messenger RNA's with Reduced Translation in Hereditary Cataracts in Mice.
JO  - Science
JF  - Science
Y1  - 1980/11/21/
VL  - 210
IS  - 4472
M3  - Article
SP  - 914
EP  - 916
SN  - 00368075
AB  - In vitro translation experiments showed that the lens fiber cells of two hereditary cataracts in mice (Nakano and Philly) possessed a full complement of crystallin messenger RNA's, despite severely reduced synthesis of crystallin in these cells. The reduction in synthesis in the lens fiber cells correlated with the increase in Na+ and the decrease in K+, which occurs during cataractogenesis. In contrast to the fiber cells, the epithelial cells continued to synthesize crystallins in the cataractous lenses. Crystallin synthesis was stimulated in the fiber cells by raising the K+ concentration and lowering the Na+ concentration in the cultured lenses. The reduction in crystallin synthesis in the initial stages of cataractogenesis in the Nakano and Philly lenses thus appears to be due to poor utilization of crystallin messenger RNA's in the fiber cells. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266805; SHINOHARA, TOSHIMICHI 1; PIATIGORSKY, JORAM 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 11/21/1980, Vol. 210 Issue 4472, p914; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - SEKIZAWA, TSUYOSHI
AU  - OPENSHAW, HARRY
AU  - WOHLENBERG, CHARLES
AU  - NOTKINS, ABNER LOUIS
T1  - Latency of Herpes Simplex Virus in Absence of Neutralizing Antibody: Model for Reactivation.
JO  - Science
JF  - Science
Y1  - 1980/11/28/
VL  - 210
IS  - 4473
M3  - Article
SP  - 1026
EP  - 1028
SN  - 00368075
AB  - Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266848; SEKIZAWA, TSUYOSHI 1; OPENSHAW, HARRY 1; WOHLENBERG, CHARLES 1; NOTKINS, ABNER LOUIS 1; Affiliations: 1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/28/1980, Vol. 210 Issue 4473, p1026; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Beebe, Gilbert W.
T1  - Record Linkage Systems--Canada vs the United States.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1980/12//
VL  - 70
IS  - 12
M3  - Article
SP  - 1246
EP  - 1248
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents a comparison of linking national data systems that are being used by Canada and the U.S. to monitor health and to facilitate large-scale epidemiological studies of health hazards. Canada, as far as these systems are concerned, is making remarkable progress. The Canadian Mortality Data Base, tape file of all 4 million deaths in Canada for 1950-1977, and many other systems are powerful and economical tools for exploring genetic, environmental, and iatrogenic influences on health. The data resources of the U.S. Census Bureau , the Social Security Administration and many others has its own legal and administrative restrictions on access to its records.
KW  - EPIDEMIOLOGY -- Research
KW  - PUBLIC health -- Evaluation
KW  - PUBLIC health administration
KW  - PUBLIC health surveillance
KW  - HEALTH risk assessment
KW  - MORTALITY -- Statistics
KW  - CANADA
KW  - UNITED States
KW  - UNITED States. Bureau of the Census
N1  - Accession Number: 4952311; Beebe, Gilbert W. 1; Affiliation:  1: Clinical Epidemiology Branch, National Cancer Institute, Rm 5A21 Landow Bldg., Bethesda, MD 20205.; Source Info: Dec1980, Vol. 70 Issue 12, p1246; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: PUBLIC health -- Evaluation; Subject Term: PUBLIC health administration; Subject Term: PUBLIC health surveillance; Subject Term: HEALTH risk assessment; Subject Term: MORTALITY -- Statistics; Subject Term: CANADA; Subject Term: UNITED States; Company/Entity: UNITED States. Bureau of the Census; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wesley McBride, O.
AU  - Peterson, Jane L.
T1  - CHROMOSOME-MEDIATED GENE TRANSFER IN MAMMALIAN CELLS.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1980/12//
VL  - 14
M3  - Article
SP  - 321
EP  - 345
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Analyzes the process of chromosome-mediated gene transfer.  Methods of chromosome transfer and transfer frequency; Uptake and expression of transgenome; Cytological detection of chromosome fragments.
KW  - GENETIC transformation
KW  - CHROMOSOMES
KW  - TRANSGENES
KW  - CYTOLOGY
N1  - Accession Number: 12409253; Wesley McBride, O. 1 Peterson, Jane L. 1; Affiliation:  1: Laboratory of Biochemistry, Division of Cancer Biology and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland; Source Info: 1980, Vol. 14, p321; Subject Term: GENETIC transformation; Subject Term: CHROMOSOMES; Subject Term: TRANSGENES; Subject Term: CYTOLOGY; Number of Pages: 25p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Dourmashkin, R. R.
AU  - Deteix, Patrice
AU  - Simone, C. B.
AU  - Henkart, P.
T1  - Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1980/12//
VL  - 42
IS  - 3
M3  - Article
SP  - 554
EP  - 560
PB  - Wiley-Blackwell
SN  - 00099104
AB  - To test the hypothesis that complement-mediated cell lysis and cell -mediated cytotoxicity operate by analogous mechanisms. cell membranes from two antibody-dependent cytotoxicity systems were examined by electron microscopy alter negative staining. Ring- shaped membrane lesions generally similar to. but larger than, those previously described for complement lysis were observed. These findings are in agreement with recent measurements of larger functional pores for ADCC than complement. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ELECTRON microscopy
KW  - MICROSCOPY
KW  - ELECTRON microscopic diagnosis
KW  - CELL membranes
KW  - BIOLOGICAL membranes
KW  - BACTERIAL cell walls
N1  - Accession Number: 16443738; Dourmashkin, R. R. 1,2 Deteix, Patrice 3 Simone, C. B. 1,2 Henkart, P. 1,2; Affiliation:  1: Section of Electron Microscopy und Department of Cell Pathology, Clinical  Research Centre, Harrow, UK.  2: Immunology Branch, National Cancer Institute National Institute of Health, Bethesda, Maryland, USA.  3: Hôpital E. Herriot, Clinique de Nephrologie, 69374 Lyon, Cedex 2, France.; Source Info: Dec1980, Vol. 42 Issue 3, p554; Subject Term: ELECTRON microscopy; Subject Term: MICROSCOPY; Subject Term: ELECTRON microscopic diagnosis; Subject Term: CELL membranes; Subject Term: BIOLOGICAL membranes; Subject Term: BACTERIAL cell walls; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - JORDAN, ELKE
T1  - Nucleic Acid Sequences: Data Bank.
JO  - Science
JF  - Science
Y1  - 1980/12/05/
VL  - 210
IS  - 4474
M3  - Article
SP  - 1074
EP  - 1074
SN  - 00368075
N1  - Accession Number: 85266858; JORDAN, ELKE 1; Affiliations: 1: Genetics Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 12/ 5/1980, Vol. 210 Issue 4474, p1074; Number of Pages: 1/6p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KAISER-KUPFER, MURIEL I.
AU  - DE MONASTERIO, FRANCISCO M.
AU  - VALLE, DAVID
AU  - WALSER, MACKENSIE
AU  - BRUSILOW, SAUL
T1  - Gyrate Atrophy of the Choroid and Retina: Improved Visual Function Following Reduction of Plasma Ornithine by Diet.
JO  - Science
JF  - Science
Y1  - 1980/12/05/
VL  - 210
IS  - 4474
M3  - Article
SP  - 1128
EP  - 1131
SN  - 00368075
AB  - In a patient with gyrate atrophy of the choroid and retina, an arginine-deficient diet has reduced plasma ornithine concentration fivefold during the past 20 months. Subjective improvement in her visual function was noted approximately 15 months after institution of her diet. This has been documented by improvements in the electroretinogram, dark-adaptation, and color vision. The improvement involves rod and, to a lesser extent, cone function. The results, although preliminary and limited to a single patient, suggest that reduction of plasma ornithine with a low arginine diet is beneficial in this disease. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266888; KAISER-KUPFER, MURIEL I. 1; DE MONASTERIO, FRANCISCO M. 1; VALLE, DAVID 2; WALSER, MACKENSIE 2; BRUSILOW, SAUL 2; Affiliations: 1: Clinical Branch, National Eye Institute, Bethesda, Maryland 20205; 2: Howard Hughes Medical Institute Laboratory and Departments of Pediatrics, Pharmacology and Experimental Therapeutics and Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205; Issue Info: 12/ 5/1980, Vol. 210 Issue 4474, p1128; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PIOMELLI, SERGIO
AU  - CORASH, LAURENCE
AU  - CORASH, MICHELE BEIGEL
AU  - SEAMAN, CAROL
AU  - MUSHAK, PAUL
AU  - GLOVER, BARBARA
AU  - PADGETT, RICHARD
T1  - Blood Lead Concentrations in a Remote Himalayan Population.
JO  - Science
JF  - Science
Y1  - 1980/12/05/
VL  - 210
IS  - 4474
M3  - Article
SP  - 1135
EP  - 1137
SN  - 00368075
AB  - The lead content in the air at the foothills of the Himalayas in Nepal was found to be negligible. The concentration of lead in the blood of 103 children and adults living in this region was found to average 3.4 micrograms per deciliter, a level substantially lower than that found in industrialized populations. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266891; PIOMELLI, SERGIO 1; CORASH, LAURENCE 2; CORASH, MICHELE BEIGEL 3; SEAMAN, CAROL 4; MUSHAK, PAUL 5; GLOVER, BARBARA 5; PADGETT, RICHARD 5; Affiliations: 1: Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York 10032; 2: Department of Clinical Pathology, National Institutes of Health, Bethesda, Maryland 20014; 3: Office of the General Counsel, Environmental Protection Agency, Washington, D.C. 20406; 4: Department of Pediatrics, Columbia University College of Physicians and Surgeons; 5: Department of Pathology, University of North Carolina School of Medicine, Chapel Hill 27514; Issue Info: 12/ 5/1980, Vol. 210 Issue 4474, p1135; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - STETTEN JR., DEWITT
T1  - Eradication.
JO  - Science
JF  - Science
Y1  - 1980/12/12/
VL  - 210
IS  - 4475
M3  - Article
SP  - 1203
EP  - 1203
SN  - 00368075
N1  - Accession Number: 85266905; STETTEN JR., DEWITT 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1203; Number of Pages: 1p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - CHANG, ESTHER H.
AU  - ELLIS, RONALD W.
AU  - SCOLNICK, EDWARD M.
AU  - LOWY, DOUGLAS R.
T1  - Transformation by Cloned Harvey Murine Sarcoma Virus DNA: Efficiency Increased by Long Terminal Repeat DNA.
JO  - Science
JF  - Science
Y1  - 1980/12/12/
VL  - 210
IS  - 4475
M3  - Article
SP  - 1249
EP  - 1251
SN  - 00368075
AB  - The coding sequences for the transforming (src) protein (p21) of Harvey murine sarcoma virus have been localized to a 1.3 kilobase pair segment near the 5' end of the viral genome. Ligation of the viral terminal repeat DNA to the left end of the src region DNA markedly enhanced the low transforming efficiency of the src region DNA. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85266926; CHANG, ESTHER H. 1; ELLIS, RONALD W. 1; SCOLNICK, EDWARD M. 1; LOWY, DOUGLAS R. 1; Affiliations: 1: Dermatology Branch and Tumor Virus Genetics Branch, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1249; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - LEWY, ALFRED J.
AU  - WEHR, THOMAS A.
AU  - GOODWIN, FREDERICK K.
AU  - NEWSOME, DAVID A.
AU  - MARKEY, S. P.
T1  - Light Suppresses Melatonm Secretion in Humans.
JO  - Science
JF  - Science
Y1  - 1980/12/12/
VL  - 210
IS  - 4475
M3  - Article
SP  - 1267
EP  - 1269
SN  - 00368075
AB  - Bright artificial light suppressed nocturnal secretion of melatonin in six normal human subjects. Room light of less intensity, which is sufficient to suppress melatonin secretion in other mammals, failed to do so in humans. In contrast to the results of previous experiments in which ordinary room light was used, these findings establish that the human response to light is qualitatively similar to that of other mammals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85266933; LEWY, ALFRED J. 1; WEHR, THOMAS A. 1; GOODWIN, FREDERICK K. 1; NEWSOME, DAVID A. 2; MARKEY, S. P. 3; Affiliations: 1: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1267; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SALLER, CHARLES F.
AU  - CHIODO, LOIS A.
T1  - Glucose Suppresses Basal Firing and Haloperidol-Induced Increases in the Firing Rate of Central Dopaminergic Neurons.
JO  - Science
JF  - Science
Y1  - 1980/12/12/
VL  - 210
IS  - 4475
M3  - Article
SP  - 1269
EP  - 1271
SN  - 00368075
AB  - In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85266934; SALLER, CHARLES F. 1; CHIODO, LOIS A. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Psychobiology Program, Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1269; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-07141-000
AN  - 9999-07141-000
AU  - Glynn, Thomas J.
T1  - Community Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1981///
AD  - Glynn, Thomas J., National Institute on Drug Abuse, 5600 Fishers Lane, Rockville, Maryland, United States, 20857
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-07141-000. Other Names: Psychological Sense of Community Instrument. Partial author list: First Author & Affiliation: Glynn, Thomas J.; National Institute on Drug Abuse, Rockville, Maryland, United States. Release Date: 20111212. Correction Date: 20151207. Instrument Type: Inventory/Questionnaire. Test Format: items are rated on a 5-point Likert scale ranging from 'strongly agree' to 'strongly disagree.'. Language: English. Constructs: Psychological Sense of Community; Classification: Social, Group, and Interpersonal Relationships (7600). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Community Questionnaire is to measure the psychological sense of community.
AB  - Description: The Community Questionnaire (Glynn, 1981) was developed to measure what Sarason (1974) termed as a 'psychological sense of community' (PSC)--a sense of belonging to one's community. Based on PSC behaviors and subconcepts identified in the literature review, a 14-stem sentence completion form was designed and administered to a sample of 37 respondents across 8 communities. For each PSC-related behavior or subconcept identified from each method, an attitude item directed at community-of-residence was developed. This resulted in 178 items that were assembled in a scale allowing the behavior or attitude to be rated. The instrument was designed to consist of 3 sections and take approximately 25 minutes to complete. The first part covers demographic data; the second part presents attitude and behavior statements rated on a scale; and the third part consists of several open-ended items tapping the subject's community participation, awareness, and competence. Items on Part II were selected from a judge's scale, with those in the lowest third of the t ratios being discarded. Then any remaining items rated as irrelevant by one-third or more of the judges was also discarded. This left 115 items. Those 60 items with the highest t ratios were then selected, with two exceptions. Each of the 60 selected items was then matched by the same item with the addition of the stem 'In an ideal community...' Subscales consisting of 8 competence items and 6 satisfaction items were added. Multiple regression analyses were performed using the criterion variables: Actual sense of community, Ideal sense of community, Community satisfaction, Community competence, and Difference between Actual and Ideal sense of community. Initial estimates of reliability of the measurements generated by the PSC instrument in 2 Maryland community samples and 1 Israeli community sample were made using Kuder-Richardson KR-20 estimates, resulting in estimates of .972 for the Actual scale and .924 for the Ideal scale. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Actual Community
KW  - Community Questionnaire
KW  - Community Satisfaction
KW  - Gemeinschraft Relationships
KW  - Ideal Community
KW  - Psychological Sense of Community
KW  - Psychometric Properties
U5  - Community Questionnaire [Test Development]Psychological sense of community: Measurement and application. (AN: 1982-04728-001 from PsycINFO) Glynn, Thomas J.; Sep, 1981. Source: Human Relations. 34(9), Sage Publications, US; Sep, 1981; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Respondents from Three Dissimilar Communities Aged 18 Years and Older; Location: United States and Israel Keywords: Actual Community; Community Questionnaire; Community Satisfaction; Gemeinschraft Relationships; Ideal Community; Psychological Sense of Community; Psychometric Properties; Subjects: Affiliation Motivation; Community Attitudes; Group Cohesion; Sense of Community; Social Integration; Social Psychology; Test Reliability; Test Validity;
DO  - 10.1037/t07141-000
L3  - Full; Full text; 999907141_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Brody, Jacob A.
T1  - Manning the Battlements of Research and Epidemiology.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1981/01//
VL  - 71
IS  - 1
M3  - Article
SP  - 70
EP  - 72
PB  - American Public Health Association
SN  - 00900036
AB  - International trends and recently proposed changes risk confining the duties of epidemiologists to support of health services delivery or to serving as functionaries within exclusively clinical departments pose a threat to the future role and training of epidemiologists. It is argued that these attempts would weaken the academic focus for epidemiologists and compromise the system of recognition and rewards available through the hierarchy of the discipline. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDEMIOLOGISTS
KW  - PUBLIC health personnel
KW  - PUBLIC health
KW  - MEDICAL care
KW  - HEALTH education
KW  - MEDICAL ethics
KW  - HEALTH promotion
KW  - MEDICAL personnel -- Training of
KW  - UNITED States
N1  - Accession Number: 4945665; Brody, Jacob A. 1; Affiliation:  1: Associate Director for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, 7550 Wisconsin Avenue, Bethesda, MD 20205.; Source Info: Jan1981, Vol. 71 Issue 1, p70; Subject Term: EPIDEMIOLOGISTS; Subject Term: PUBLIC health personnel; Subject Term: PUBLIC health; Subject Term: MEDICAL care; Subject Term: HEALTH education; Subject Term: MEDICAL ethics; Subject Term: HEALTH promotion; Subject Term: MEDICAL personnel -- Training of; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yaros, Daniel B.
T1  - RADIATION BIOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1981/01//
VL  - 31
IS  - 1
M3  - Book Review
SP  - 70
EP  - 70
SN  - 00063568
AB  - The article reviews the book "Biological Effects of Ultraviolet Radiation," by Walter Harm.
KW  - Ultraviolet radiation -- Physiological effect
KW  - Nonfiction
KW  - Harm, Walter
KW  - Biological Effects of Ultraviolet Radiation (Book)
N1  - Accession Number: 28051066; Yaros, Daniel B. 1; Affiliations: 1 : Building 37, Room 3d National Institutes of Health Bethesda, MD 2001;  Source Info: Jan1981, Vol. 31 Issue 1, p70; Subject Term: Ultraviolet radiation -- Physiological effect; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 708
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Barrett, Susanna F.
AU  - Tarone, Robert E.
AU  - Moshell, Alan N.
AU  - Ganges, Mary B.
AU  - Robbins, Jay H.
T1  - The Post-UV Colony-Forming Ability of Normal Fibroblast Strains and of the Xeroderma Pigmentosum Group G Strain.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/01//
VL  - 76
IS  - 1
M3  - Article
SP  - 59
EP  - 62
SN  - 0022202X
AB  - In xeroderma pigmentosum, an inherited disorder of defective DNA repair, post-UV colony-forming ability of fibroblasts from patients in complementation groups A through F correlates with the patients neurological status. The first xeroderma pigmentosum patient assigned to the recently discovered group G had the neurological abnormalities of XP. We have determined the post-UV colony-forming ability of cultured fibroblasts from this patient and from 5 more control donors. Log-phase fibroblasts were irradiated with 254 no UV light from a germicidal lamp, trypsinized, and replated at known densities. After 2 to 4 weeks incubation the cells were fixed, stained and scored for colony formation. The strains post-UV colony-forming ability curves were obtained by plotting the log of the percent remaining post- UV colony-forming ability as a function of the UV dose. The post-UV colony-forming ability of 2 of the 5 new normal strains was in the previously defined control donor zone, but that of the other 3 extended down to the level of the most resistant xeroderma pigmentosum strain. The post-UV colony-forming ability curve of the group G fibroblasts was not significantly different from the curves of the group D fibroblast strains from patients with clinical histories similar to that of the group G patient. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FIBROBLASTS
KW  - XERODERMA pigmentosum
KW  - GENETIC disorders
KW  - DNA repair
KW  - NEUROLOGY
KW  - IRRADIATION
N1  - Accession Number: 12524886; Barrett, Susanna F. 1 Tarone, Robert E. 1 Moshell, Alan N. 1 Ganges, Mary B. 1 Robbins, Jay H. 1; Affiliation:  1: Dermatology and Biometry Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1981, Vol. 76 Issue 1, p59; Subject Term: FIBROBLASTS; Subject Term: XERODERMA pigmentosum; Subject Term: GENETIC disorders; Subject Term: DNA repair; Subject Term: NEUROLOGY; Subject Term: IRRADIATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12524886
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2009-11819-001
AN  - 2009-11819-001
AU  - Parloff, Morris B.
T1  - An extraordinary life.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1981///
VL  - 7
IS  - 3
SP  - 383
EP  - 384
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Parloff, Morris B., Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US, 20857
N1  - Accession Number: 2009-11819-001. Partial author list: First Author & Affiliation: Parloff, Morris B.; Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Obituary. Language: English. Major Descriptor: Psychologists. Minor Descriptor: Scientific Communication. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Page Count: 2. Issue Publication Date: 1981. 
AB  - Remembers David Shakow, Scientist Emeritus of the National Institute of Mental Health and a founding member of the Schizophrenia Bulletin's Editorial Advisory Board. The author speaks of his personal experiences with Shakow, and celebrates his good fortune in having been some small part of it for nearly three decades. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - David Shakow
KW  - psychologist
KW  - personal experiences
KW  - 1981
KW  - Psychologists
KW  - Scientific Communication
KW  - 1981
DO  - 10.1093/schbul/7.3.383
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - MAXFIELD, F. R.
AU  - WILLINGHAM, M. C.
AU  - PASTAN, I.
AU  - DRAGSTEN, P.
AU  - CHENG, S.-Y.
T1  - Binding and Mobility of the Cell Surface Receptors for 3,3',5-Triiodo-L-Thyronine.
JO  - Science
JF  - Science
Y1  - 1981/01/02/
VL  - 211
IS  - 4477
M3  - Article
SP  - 63
EP  - 65
SN  - 00368075
AB  - A fluorescent derivative of the thyroid hormone 3,3',5-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. Video intensification fluorescence microscopy indicates that binding occurs at the plasma membrane. Diffusion coefficients, obtained by fluorescence photobleaching recovery, are consistent with binding to a protein receptor on the cell surface. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85267008; MAXFIELD, F. R. 1; WILLINGHAM, M. C. 1; PASTAN, I. 1; DRAGSTEN, P. 2; CHENG, S.-Y. 3; Affiliations: 1: National Cancer Institute, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Theoretical Biology, National Cancer Institute; 3: Clinical Endocrinology Branch, National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health; Issue Info: 1/ 2/1981, Vol. 211 Issue 4477, p63; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Atlas, Daphne
AU  - Sabol, Steven L.
T1  - Interaction of Clonidine and Clonidine Analogues with α-Adrenergic Receptors of Neuroblastoma × Glioma Hybrid Cells and Rat Brain.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/01/15/
VL  - 113
IS  - 3
M3  - Article
SP  - 521
EP  - 529
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Clonidine and several analogues of clonidine are shown to be useful probes for α2-adrenergic receptors in a comparative study of ligand binding and inhibition of adenylate cyclase. The α-adrenergic properties of a new potential probe, N-(4-hydroxyphenacetyl)-4-aminoclonidine hydrochloride, are described. [³H]Clonidine binds to s-receptors of NG108-15 neuroblastoma × glioma hybrid cell membranes with Kd values of 1.7 and 33 nM for putative high-affinity and low-affinity sites, respectively, p-Aminoclonidine and hydroxyphenacetyl aminocionidine displace [³H]clonidine from the high-affinity sites with Kd values of 2.3 and 5.8 nM, respectively. Rat brain α2-receptors also exhibit high affinity toward clonidine, p-aminoclonidine, and hydroxyphenacetyl aminoclonidine, as determined by displacement of specifically bound [³H]clonidine. Clonidine, p-aminoclonidine, and hydroxyphenacetyl aminocionidine elicit modest inhibition (up to 24%) of NG108-15 adenylate cyclase by interaction with α2-receptors (Kd,app 300, 50, and 130 nM, respectively); these compounds also partially reverse the inhibition elicited by (-)-norepinephrine. Components of the adenylate cyclase assay mixture, particularly ATP, GTP, sodium ions, and a nucleoside-triphosphate-regenerating system, decrease the high-affinity [³H]clonidine binding to NG108-15 membranes; in the presence of these components, α-receptors possess only low affinity (Kd 43 nM) for [³H]clonidine. These results are consistent with the concept that certain components required for the receptor-mediated inhibition of adenylate cyclase convert α2-receptors from a highaffinity inactive state to a low-affinity active state. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CLONIDINE
KW  - ALPHA adrenoceptors
KW  - NEUROBLASTOMA
KW  - GLIOMAS
KW  - LIGAND binding (Biochemistry)
KW  - ADENYLATE cyclase
KW  - INHIBITORS
N1  - Accession Number: 11227619; Atlas, Daphne 1 Sabol, Steven L. 1; Affiliation:  1: Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute and Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism and Digestive Disease, National Institutes of Health, Bethesda, Maryland; Source Info: 1/15/81, Vol. 113 Issue 3, p521; Subject Term: CLONIDINE; Subject Term: ALPHA adrenoceptors; Subject Term: NEUROBLASTOMA; Subject Term: GLIOMAS; Subject Term: LIGAND binding (Biochemistry); Subject Term: ADENYLATE cyclase; Subject Term: INHIBITORS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - FERGUSON, H. BRUCE
AU  - RAPOPORT, JUDITH L.
AU  - WEINGARTNER, HERBERT
AU  - SWANSON, JAMES M.
AU  - KINSBOURNE, MARCEL
T1  - Food Dyes and Impairment of Performance in Hyperactive Children.
JO  - Science
JF  - Science
Y1  - 1981/01/23/
VL  - 211
IS  - 4480
M3  - Article
SP  - 410
EP  - 411
SN  - 00368075
N1  - Accession Number: 85267124; FERGUSON, H. BRUCE 1; RAPOPORT, JUDITH L. 2; WEINGARTNER, HERBERT 3; SWANSON, JAMES M. 4,5; KINSBOURNE, MARCEL 6; Affiliations: 1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Unit on Childhood Mental Illness, National Institute of Mental Health; 3: Laboratory of Psychology and Psychopathology, National Institute of Mental Health; 4: Fairview State Hospital, Costa Mesa, California 92626; 5: Hospital for Sick Children, Toronto, Ontario, Canada M5S IA8; 6: Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts 02254; Issue Info: 1/23/1981, Vol. 211 Issue 4480, p410; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WALLACE, GORDON D.
T1  - Mouse Pox Threat.
JO  - Science
JF  - Science
Y1  - 1981/01/30/
VL  - 211
IS  - 4481
M3  - Article
SP  - 438
EP  - 438
SN  - 00368075
N1  - Accession Number: 85196761; WALLACE, GORDON D. 1,2; Affiliations: 1: Office, Scientific Director, National Institute of Allergy; 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/30/1981, Vol. 211 Issue 4481, p438; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Riley, Matilda White
T1  - HOW OLD IS AGE 75?
JO  - American Sociologist
JF  - American Sociologist
Y1  - 1981/02//
VL  - 16
IS  - 1
M3  - Article
SP  - 38
EP  - 40
SN  - 00031232
AB  - This article reflects on the progress of the American Sociological Association (ASA) from 1905 to 1980.  The author relates that when she took office elate in 1949, there were approximately 2,700 members on the Society's roles.  Ten years later there were 7,000.  With the Reorganization Committee of 1950 anticipating the potential, certain goals for the Association were set early in the decade.  There were eight goals that the society was determined to accomplish.  It is a matter of record that considerable progress was made during the decade of the 1950s in moving toward these goals especially the first six Constitutional changes were affected.  membership participation was broadened.  An executive office was organized.  Several new publications were started.  Membership services generally were expanded.  All the annual meeting, over 300 papers were presented in 1960 in contrast to 77 in 1950.  In two important respects, however, the mid-century ASA was somewhat less effective in performing its supportive role in expanding the uses of sociology and in aiding the development of the discipline.  For example, responding to indications that sociologists were needed in a variety of practicing professions, ASA together with Russell Sage Foundation, undertook a series of bulletins on the fields of sociological application.
KW  - ASSOCIATIONS, institutions, etc.
KW  - SOCIOLOGY -- United States
KW  - SOCIOLOGY
KW  - MEMBERSHIP
KW  - SOCIOLOGISTS
KW  - PROFESSIONS
KW  - CHARITABLE uses, trusts, & foundations (Law)
KW  - UNITED States
KW  - AMERICAN Sociological Association
N1  - Accession Number: 4944948; Riley, Matilda White 1; Affiliation:  1: Bowdoin College and National Institute on Aging; Source Info: Feb81, Vol. 16 Issue 1, p38; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: SOCIOLOGY -- United States; Subject Term: SOCIOLOGY; Subject Term: MEMBERSHIP; Subject Term: SOCIOLOGISTS; Subject Term: PROFESSIONS; Subject Term: CHARITABLE uses, trusts, & foundations (Law); Subject Term: UNITED States; Company/Entity: AMERICAN Sociological Association DUNS Number: 074801341; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 813211 Grantmaking Foundations; NAICS/Industry Codes: 813319 Other Social Advocacy Organizations; NAICS/Industry Codes: 813920 Professional Organizations; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pandolfl, F.
AU  - Strong, D. M.
AU  - Slease, R. B.
AU  - Bonnard, G. D.
T1  - Serological and functional characterization of human T cell subsets.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/02//
VL  - 43
IS  - 2
M3  - Article
SP  - 319
EP  - 328
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Two different specific anti-human T cell sera were studied. One was raised against fetal thymocytes (anti-HTY) and the other against human cultured T cells (anti-CTC) grown in the presence of conditioned medium from phytohaemagglutinin-stimulated peripheral blood mononuclear leucocytes (PBL). These sera, after various absorptions, reacted in microcytotoxicity assays against T cells, but not with B and null cells in the peripheral blood of both normal donors and patients with non-T leukaemias. A clear distinction between the labelling density of T versus B cells was also documented with the fluorescence- activated cell-sorter (FACS) analyses. These two sera were further absorbed on T cells from different sources with the aim of obtaining reagents specific for T cell subsets. Two reagents resulting from these absorptions were found to react with subsets of T-PBL. (1) Anti-HTY, after absorption with cells of a T-chronic lymphocyte leukaemia (T-CLL) expressing receptors for the Fc portion of IgG, reacted with thymocytes, 40-50% of normal T-PBL and only with those T cells that were not inhibited by theophylline in their ability to rosette with sheep erythrocytes. When PBL were preincubated with the absorbed serum and complement, the remaining cells had markedly diminished lymphoproliferative responses to lectins and in mixed lymphocyte culture (MLC), but they still responded well to tetanus toxoid (t.tox.). (2) Anti-CTC, after absorption with the MOLT-4 cell line reacted with about 30%, of T-PBL and with the majority of the T-CLL cells with Fc receptors, as documented by cytotoxicity and FACS analyses. When normal PBL were preincubated with this absorbed serum and complement, the remaining cells had enhanced lymphoproliferative responses to lectins and especially to t.tox. and in MLC. Thus, these antisera, obtained following some rather simple absorption steps, were able to divide human T cells into two major and distinct subpopulations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ABSORPTION
KW  - LYMPHOCYTES
KW  - T cells
KW  - SERUM
KW  - BLOOD plasma
KW  - BLOOD cells
N1  - Accession Number: 16012019; Pandolfl, F. 1 Strong, D. M. 2,3 Slease, R. B. 2,3 Bonnard, G. D. 2,3; Affiliation:  1: Division of Infectious Disease II, Institute of Internal Medicine III, University of Rome, Italy.  2: Laboratory of Immunodiagnosis, National Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, USA.  3: Transplantation Research Branch, Naval Medical Research Institute, Bethesda, Maryland, USA.; Source Info: Feb1981, Vol. 43 Issue 2, p319; Subject Term: ABSORPTION; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: BLOOD cells; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kraemer, Kenneth H.
AU  - Waters, Haywood L.
AU  - Cohen, Lawrence F.
AU  - Popescu, Nicolae C.
AU  - Amsbaugh, Suzanne C.
AU  - DiPaolo, Joseph A.
AU  - Glaubiger, Daniel
AU  - Ellingson, Owen L.
AU  - Tarone, Robert E.
T1  - Effects of 8-Methoxypsoralen and Ultraviolet Radiation on Human Lymphoid Cells <em>in Vitro</em>.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/02//
VL  - 76
IS  - 2
M3  - Article
SP  - 80
EP  - 87
SN  - 0022202X
AB  - Oral 8-methoxypsoralen (8-MOP) plus high-intensity long-wavelength ultraviolet radiation (UV-A) is used clinically to induce remissions of psoriasis and mycosis fungoides, Leukocytes in 8-MOP containing blood receive UV-A exposure when circulating through the dermis during therapy. The present study utilizes an <em>in vitro</em> assay system to permit quantitation and correlation of multiple biological and physical alterations in human lymphoid cells induced by 8-MOP plus UV-A treatment. Additive inhibition of lymphoid cell DNA synthesis by 8-MOP (0.01 to 1 μg/ml) plus UV-A (1,000 to 29,000 J/m²) was accompanied by a synergistic potentiation of cell killing in the therapeutic exposure range. Reduction in tritiated thymidine (³HTdR) incorporation to 65-70% of control value was associated with normal survival; while ³HTdR incorporation of less than 50% of control induced by any 8-MOP plus UV-A combination tested was associated with less than 10% survival, 8-MOP-DNA-cross-links were detected by the alkaline elution assay only when ³HTdR incorporation was reduced to less than 50% of control. The relative number of crosslinks increased proportionately with further 8-MOP plus UV-A-induced reduction in ³HTdR incorporation. 8-MOP plus UV-A induced at most approximately a 2-fold increase in sister chromatid exchanges (SCE) per chromosome in lymphocytes or lymphoblastoid cells, Increasing 8-MOP plus UV-A exposure resulted in marked toxicity with few cells progressing to second division metaphases and no further increase in SCE's per chromosome, Addition of 13-cis retinoic acid (1μg/ml) to the lymphoblastoid cells prior to 8-MOP plus UV-A treatment did not significantly alter the ³HTdR incorporation or cell survival. These studies dermonstrate that <em>in vitro</em> exposure of human lymphoid cells to therapeutic levels of 8-MOP and UV-A may decrease cellular DNA synthesis, produce DNA 8-MOP interstrand cross-links, reduce cell viability and induce small increases in sister chromosome exchanges. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOID tissue
KW  - ULTRAVIOLET radiation
KW  - LEUCOCYTES
KW  - DNA
KW  - MYCOSIS fungoides
KW  - LYMPHOPROLIFERATIVE disorders
N1  - Accession Number: 12525352; Kraemer, Kenneth H. 1 Waters, Haywood L. 1 Cohen, Lawrence F. 2 Popescu, Nicolae C. 3 Amsbaugh, Suzanne C. 3 DiPaolo, Joseph A. 3 Glaubiger, Daniel 2 Ellingson, Owen L. 4 Tarone, Robert E. 5; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland.  2: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland.  3: Laboratory of Biology, National Cancer Institute, Bethesda, Maryland.  4: Electrooptics Branch, Division of Electronic Products, Bureau of Radiologic Health, Food and Drug Administration, Rockville, Maryland, U.S.A.  5: Biometry Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Feb81, Vol. 76 Issue 2, p80; Subject Term: LYMPHOID tissue; Subject Term: ULTRAVIOLET radiation; Subject Term: LEUCOCYTES; Subject Term: DNA; Subject Term: MYCOSIS fungoides; Subject Term: LYMPHOPROLIFERATIVE disorders; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12525352
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hintner, H.
AU  - Stingl, G.
AU  - Schuler, G.
AU  - Fritsch, P.
AU  - Stanley, J.
AU  - Katz, S.
AU  - Wolff, K.
T1  - Immunofluorescence Mapping of Antigenic Determinants within the Dermal-epidermal Junction in Mechanobullous Diseases.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/02//
VL  - 76
IS  - 2
M3  - Article
SP  - 113
EP  - 118
SN  - 0022202X
AB  - The classification of mechanobullous diseases often depends on the electron microscopic distinction of intradermal (dermolytic), junctional and intraepidermal sites of cleavage. Electron microscopy is tedious and time consuming. In this report we describe a different approach to the determination of the cleavage plane by using a method which recognizes subtle differences in the localization of antigenic structures relative to the cleavage plane. Cryostat sections of lesional and extralesional skin of 3 patients with dermolytic epidermolysis bullosa, 3 with epidermolytic epidermolysis bullosa and 8 with junctional epidermolysis bullosa were examined by immunofluorescence, with specific antisera against type IV collagen (localized within the basal lamina); against laminin (noncollagenous protein, localized in the lamina lucida); and with bullous pemphigoid antibodies (directed against the bullous pemphigoid antigen localized in the lamina lucida). All specimens were also examined by electron microscopy. In dermolytic epidermolysis bullosa (where cleft formation occurs intradermally) type IV collagen, laminin and the bullous pemphigoid antigen were consistently found in the roof of the blister, whereas in junctional epidermolysis bullosa (where the cleft occurs in the lamina lucida) type IV collagen and laminin were found on the floor of the blister whereas bullous pemphigold antigen was present mainly on the roof but focally also on the floor, of the blister. In epidermolytic epidermolysis bullosa (where the cleft is intraepidermal) all antigens were localized below the cleavage plane. In all cases electron microscopy confirmed the level of cleft formation predicted from the immunofluorescence mapping of the antigenic sites. The described method equals electron microscopy in accuracy but it is more rapid and simpler to perform. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOFLUORESCENCE
KW  - ANTIGENIC determinants
KW  - ELECTRON microscopy
KW  - INTRADERMAL injections
KW  - CRYOTOMY
KW  - EPIDERMOLYSIS bullosa
KW  - IMMUNE serums
N1  - Accession Number: 12525447; Hintner, H. 1 Stingl, G. 1 Schuler, G. 1 Fritsch, P. 1 Stanley, J. 2 Katz, S. 2 Wolff, K. 1; Affiliation:  1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.  2: Department of Dermatology Branch, National Cancer Institute and Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb81, Vol. 76 Issue 2, p113; Subject Term: IMMUNOFLUORESCENCE; Subject Term: ANTIGENIC determinants; Subject Term: ELECTRON microscopy; Subject Term: INTRADERMAL injections; Subject Term: CRYOTOMY; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: IMMUNE serums; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12525447
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yuspa, Stuart H.
AU  - Koehler, Barbara
AU  - Kulesz-Martin, Molly
AU  - Hennings, Henry
T1  - Clonal Growth of Mouse Epidermal Cells in Medium with Reduced Calcium Concentration.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/02//
VL  - 76
IS  - 2
M3  - Article
SP  - 144
EP  - 146
SN  - 0022202X
AB  - Mouse keratinocytes can he grown at clonal densities in dermal fibroblast conditioned medium with a calcium concentration of 0.02 MM. Colony forming efficiencies of approximately 1-3% can be achieved with primary and secondary cultures and up to 6% with selected subclones. A substrate of frozen-thawed dermal fibroblasts enhances colony formation over plastic. Colony size increases more rapidly in the presence of epidermal growth factor in conditioned medium, Conditioning of medium by fibroblasts is optimum after day 6 of culture and conditioned medium can be stored at -20°C for at least 4 mo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - FIBROBLASTS
KW  - CYTOKINES
KW  - COLONIES (Biology)
KW  - GROWTH factors
KW  - CLONE cells
N1  - Accession Number: 12525490; Yuspa, Stuart H. 1 Koehler, Barbara 1 Kulesz-Martin, Molly 1 Hennings, Henry 1; Affiliation:  1: In Vitro Pathogenesis Section, Laboratory of Experimental Pathology National Cancer, Institute, Bethesda, Maryland, U.S.A.; Source Info: Feb81, Vol. 76 Issue 2, p144; Subject Term: KERATINOCYTES; Subject Term: FIBROBLASTS; Subject Term: CYTOKINES; Subject Term: COLONIES (Biology); Subject Term: GROWTH factors; Subject Term: CLONE cells; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12525490
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06553-058
AN  - 2006-06553-058
AU  - Riley, Matilda White
T1  - Adult Development.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1981/02//
VL  - 26
IS  - 2
SP  - 144
EP  - 145
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06553-058. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Riley, Matilda White; National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adult Development; Developmental Stages; Psychodynamics; Sociocultural Factors. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Smelser, Neil J. (Ed); Erikson, Erik H. (Ed). Themes of Work and Love in Adulthood=Cambridge, Mass.: Harvard University Press, 1980 x + 297 pp $15 00; 1980. Page Count: 2. Issue Publication Date: Feb, 1981. 
AB  - Reviews the book, Themes of Work and Love in Adulthood edited by Neil J. Smelser and Erik H. Erikson (1980). Among the many recent works on adult development, this book is important because of its implicit emphasis on the gap between psychodynamic and sociocultural understandings. Despite the usual difficulties of interdisciplinary communication, one can discern in the chapters of the book numerous attempts to link subjective developmental processes and sociocultural contexts. Through its concentration on psychodynamic and sociocultural approaches, the book falls short of its plan to reflect the current state of research and thinking on adult development. Yet, it is the difficulties and shortcomings of the book that lay bare its unique contribution. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - work
KW  - love
KW  - adulthood
KW  - adult development
KW  - psychodynamic
KW  - sociocultural understandings
KW  - developmental processes
KW  - 1981
KW  - Adult Development
KW  - Developmental Stages
KW  - Psychodynamics
KW  - Sociocultural Factors
KW  - 1981
U2  - Smelser, Neil J. (Ed); Erikson, Erik H. (Ed). (1980); Themes of Work and Love in Adulthood; Cambridge, Mass.: Harvard University Press, 1980 x + 297 pp $15 00
DO  - 10.1037/019968
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - GREGG, RICHARD E.
AU  - ZECH, LOREN A.
AU  - SCHAEFER, ERNST J.
AU  - BREWER JR., H. BRYAN
T1  - Type III Hyperlipoproteinemia: Defective Metabolism of an Abnormal Apolipoprotein E.
JO  - Science
JF  - Science
Y1  - 1981/02/06/
VL  - 211
IS  - 4482
M3  - Article
SP  - 584
EP  - 586
SN  - 00368075
AB  - The apolipoprotein E isolated from plasma of individuals with type III hyperlipoproteinemia (HLP) shows an abnormal pattern when it is examined by isoelectric focusing. Compared to apolipoprotein Efrom normal subjects, apolipoprotein E isolated from subjects wtith type III HLP had a decreased fractional catabolic rate in vivo in both type III HLP patients and normal individuals. The delayed catabolism of apolipoprotein E in type III HLP patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84948100; GREGG, RICHARD E. 1; ZECH, LOREN A. 1; SCHAEFER, ERNST J. 1; BREWER JR., H. BRYAN 1; Affiliations: 1: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/ 6/1981, Vol. 211 Issue 4482, p584; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KEETON, T. KENT
AU  - KRUTZSCH, HENRY
AU  - LOVENBERG, WALTER
T1  - Specific and Sensitive Radioimmunoassay for 3-Methoxy-4-hydroxyphenylethyleneglycol (MOPEG).
JO  - Science
JF  - Science
Y1  - 1981/02/06/
VL  - 211
IS  - 4482
M3  - Article
SP  - 586
EP  - 588
SN  - 00368075
AB  - Antibodies that specifically bind the norepinephrine metabolite 3-methoxy- 4-hydroxyphenylethyleneglycol (MOPEG) were produced in rabbits after injection of a derivative of MOPEG conjugated with bovine thyroglobulin. A sensitive radioimmunoassay was devised with this antiserum, in which as little as 0.5 nanogram of MOPEG can be accurately measured with afinal antibody dilution of 1:180. The antibody appears to be specific for MOPEG, since tritiated MOPEG was not displacedfrom the antibodies by norepinephrine, epinephrine, dopamine, serotonin, or their major metabolites, including MOPEG-sulfate (333 nanograms each). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84948101; KEETON, T. KENT 1; KRUTZSCH, HENRY 2; LOVENBERG, WALTER 3; Affiliations: 1: Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284; 2: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 3: Section on Biochemical Pharmacology, National Heart, Lung, and Blood Institute; Issue Info: 2/ 6/1981, Vol. 211 Issue 4482, p586; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINGARTNER, HERBERT
AU  - GOLD, PHILIP
AU  - BALLENGER, JAMES C.
AU  - SMALLBERG, SHEILA A.
AU  - SUMMERS, RICHARD
AU  - RUBINOW, DAVID R.
AU  - POST, ROBERT M.
AU  - GOODWIN, FREDERICK K.
T1  - Effects of Vasopressin on Human Memory Functions.
JO  - Science
JF  - Science
Y1  - 1981/02/06/
VL  - 211
IS  - 4482
M3  - Article
SP  - 601
EP  - 603
SN  - 00368075
AB  - Arginine vasopressin and a number of its synthetic analogs augment memory functions in experimental animals. One of these analogs, 1-desamino-8-Darginine vasopressin (DDAVP), influences human learning and memory. Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVPfor a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency (reliability) of recall. DDAVP also appears to reverse partially the retrograde amnesia that follows electroconvulsive treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84948108; WEINGARTNER, HERBERT 1; GOLD, PHILIP 1; BALLENGER, JAMES C. 1; SMALLBERG, SHEILA A. 1; SUMMERS, RICHARD 1; RUBINOW, DAVID R. 1; POST, ROBERT M. 1; GOODWIN, FREDERICK K. 1; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 2/ 6/1981, Vol. 211 Issue 4482, p601; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kalberer Jr., John T.
T1  - Grant Length and Budget Stability at the National Institutes of Health.
JO  - Science
JF  - Science
Y1  - 1981/02/13/
VL  - 211
IS  - 4483
M3  - Article
SP  - 675
EP  - 680
SN  - 00368075
N1  - Accession Number: 88003186; Kalberer Jr., John T. 1; Affiliations: 1: Assistant director, Office for Medical Applications of Research, Office of the Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/13/1981, Vol. 211 Issue 4483, p675; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CRAWLEY, JACQUELINE N.
AU  - MARANGOS, PAUL J.
AU  - PAUL, STEVEN M.
AU  - SKOLNICK, PHIL
AU  - GOODWIN, FREDERICK K.
T1  - Interaction Between Purine and Benzodiazepine: Inosine Reverses Diazepam-Induced Stimulation of Mouse Exploratory Behavior.
JO  - Science
JF  - Science
Y1  - 1981/02/13/
VL  - 211
IS  - 4483
M3  - Article
SP  - 725
EP  - 727
SN  - 00368075
AB  - Inosine, 2-deoxyinosine, and 2-deoxyguanosine completely reversed the increase in exploratory activity elicited in mice by diazepam. The inhibition of exploratory behavior by purines occurred at doses that when given alone have no effect on exploratory behavior. 7-Methylinosine, which does not bind to the brain benzodiazepine binding site in vitro, had no effect on the diazepam-induced increase in exploratory behavior. Behavioral effects produced by various combinations of inosine and diazepam indicate that the interaction between purine and benzodiazepine is antagonistic and support the hypothesis that the naturally occurring purinesfunction in anxiety-related behaviors that respond to benzodiazepine treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003215; CRAWLEY, JACQUELINE N. 1; MARANGOS, PAUL J. 1; PAUL, STEVEN M. 1; SKOLNICK, PHIL 2; GOODWIN, FREDERICK K. 3; Affiliations: 1: Clinical Psychology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Bio-Organic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20205; 3: Clinical Psychology Branch, National Institute of Mental Health; Issue Info: 2/13/1981, Vol. 211 Issue 4483, p725; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DEUTSCH, J. A.
AU  - FREED, WILLIAM J.
AU  - BING, LLOYD A.
AU  - WYATT, RICHARD JED
T1  - Calcitonin: Aversive Effects in Rats?
JO  - Science
JF  - Science
Y1  - 1981/02/13/
VL  - 211
IS  - 4483
M3  - Article
SP  - 733
EP  - 734
SN  - 00368075
N1  - Accession Number: 88003220; DEUTSCH, J. A. 1; FREED, WILLIAM J. 2; BING, LLOYD A. 2; WYATT, RICHARD JED 2; Affiliations: 1: Department of Psychology, University of California, San Diego, La Jolla 92093; 2: Adult Psychiatry Branch, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/13/1981, Vol. 211 Issue 4483, p733; Number of Pages: 2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Guranowski, Andrzej B.
AU  - Chiang, Peter K.
AU  - Cantoni, Giulio L.
T1  - 5'-Methylthioadenosine Nucleosidase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/02/16/
VL  - 114
IS  - 2
M3  - Article
SP  - 293
EP  - 299
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Characterizes the enzyme 5'-methylthioadenosine nucleosidase from the seeds of Lupinus luteus.  Enzyme purification; Molecular weight; Synthetic analogs; Enzyme substrate specificity; Substitute substrates; Enzyme deamination.
KW  - NUCLEOSIDASES
KW  - PLANT enzymes
KW  - SEEDS
KW  - LUPINUS luteus
KW  - MOLECULAR weights
KW  - DEAMINATION
N1  - Accession Number: 12176818; Guranowski, Andrzej B. 1 Chiang, Peter K. 1 Cantoni, Giulio L. 1; Affiliation:  1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda; Source Info: 2/16/81, Vol. 114 Issue 2, p293; Subject Term: NUCLEOSIDASES; Subject Term: PLANT enzymes; Subject Term: SEEDS; Subject Term: LUPINUS luteus; Subject Term: MOLECULAR weights; Subject Term: DEAMINATION; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; NAICS/Industry Codes: 418320 Seed merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - LAKE, C. R.
AU  - GULLNER, H. G.
AU  - POLINSKY, R. J.
AU  - EBERT, M. H.
AU  - ZIEGLER, M. G.
AU  - BARTTER, F. C.
T1  - Essential Hypertension: Central and Peripheral Norepinephrine.
JO  - Science
JF  - Science
Y1  - 1981/02/27/
VL  - 211
IS  - 4485
M3  - Article
SP  - 955
EP  - 957
SN  - 00368075
AB  - The concentration of norepinephrine in cerebrospinalfluidfrom patients with essential hypertension is higher than that from healthy normal volunteers, but the concentrations of norepinephrine in plasma from these groups are similar. This finding indicates that central nervous system noradrenergic hyperactivity occurs in essential hypertension but apparently is not reflected in abnormal function of the peripheral sympathetic nervous system in these patients. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948157; LAKE, C. R. 1; GULLNER, H. G. 2; POLINSKY, R. J. 3; EBERT, M. H. 3; ZIEGLER, M. G. 4; BARTTER, F. C. 5; Affiliations: 1: Departments of Psychiatry and Pharmacology, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland 20014; 2: National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 3: Section of Experimental Therapeutics, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Department of Medicine, University of San Diego, La Jolla, California 92037; 5: Audie Murphy Veterans Administration Hospital, San Antonio, Texas 78284; Issue Info: 2/27/1981, Vol. 211 Issue 4485, p955; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Lawrence, E. C.
AU  - Arnaud-Battandier, F.
AU  - Grayson, Jane
AU  - Koski, Irma R.
AU  - Dooley, Nancy J.
AU  - Muchmore, A. V.
AU  - Blaese, R. M.
T1  - Ontogeny of humoral immune function in normal chickens: a comparison of immunoglobulin-secreting cells in bone marrow, spleen, lungs and intestine.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/03//
VL  - 43
IS  - 3
M3  - Article
SP  - 450
EP  - 457
PB  - Wiley-Blackwell
SN  - 00099104
AB  - A reverse haemolytic plaque assay was employed to study the ontogeny of immunoglobulin (Ig) secreting cells of either IgG, IgA, or IgM class in normal chickens. After hatching, IgM-secreting cells were detectable in the spleen by 3 days of age whereas IgG- and lgA-secreting cells were first noted at 6 days. Adult Levels of Ig-secreting cells of all three classes were attained by 31 days of age in bone marrow and two separate lymphoid populations (lamina propria and intraepithelial lymphocytes). By contrast, adult levels of Ig-secreting cells were not obtained in either the spleen or the lungs until after 50 days of age. In the case of the spleen, the delay in attainment of adult levels of total Ig-secreting cells reflected the smaller spleen size in immature birds, whereas the percentages of cells secreting Ig of each class were in the adult range by 31 days. By contrast, the numbers of cells recovered from the lungs of 50-day-old chickens were near the adult range, while the percentages of cells secreting either IgG, IgA, or IgM were much fewer than those seen in the lungs of adult chickens. These data indicate that the lungs of normal chickens are populated more slowly with Ig-secreting cells than either the bone marrow, spleen, or intestine. At all ages studied, greater numbers of Pg-secreting cells, particularly of the IgG and IgM classes, were recovered from the bone marrow and spleen as compared to the lungs and intestine. Since only a portion of the total bone marrow population was studied, these data indicate that the bone marrow may be a major site of Ig-secreting cells in chickens beginning shortly after hatching. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNOGLOBULINS
KW  - ONTOGENY
KW  - LYMPHOID tissue
KW  - LYMPHOCYTIC leukemia
KW  - LYMPHOCYTES
KW  - BONE marrow cells
KW  - HEMOLYSIS & hemolysins
KW  - CHICKENS as laboratory animals
N1  - Accession Number: 16242787; Lawrence, E. C. 1 Arnaud-Battandier, F. 1 Grayson, Jane 1 Koski, Irma R. 1 Dooley, Nancy J. 1 Muchmore, A. V. 1 Blaese, R. M. 2; Affiliation:  1: Cellular Immunology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: Department of Internal Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA.; Source Info: Mar1981, Vol. 43 Issue 3, p450; Subject Term: IMMUNOGLOBULINS; Subject Term: ONTOGENY; Subject Term: LYMPHOID tissue; Subject Term: LYMPHOCYTIC leukemia; Subject Term: LYMPHOCYTES; Subject Term: BONE marrow cells; Subject Term: HEMOLYSIS & hemolysins; Subject Term: CHICKENS as laboratory animals; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Gregory, S. H.
AU  - Kern, M.
T1  - Mitogenic response to T-cell subclasses to agarose-linked and to free ribonucleotides.
JO  - Immunology
JF  - Immunology
Y1  - 1981/03//
VL  - 42
IS  - 3
M3  - Article
SP  - 451
EP  - 457
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of θ antigen-bearing T cells comprising approximately 2% of the total thymocyte population as judged by a combined immunofluorescent/autoradiographic analysis. Thymocytes responsive to ATP and GTP are sensitive to cortisone suggesting that they are relatively immature T cells. ATP-responsive cells also preferentially aggregate with immature T cells when incubated with peanut agglutinin. GTP-responsive cells, on the other hand, do not. Nucleotides rendered insoluble by linkage to agarose via the ribose moiety are more active mitogenically at lower concentrations than either soluble nucleotides or even nucleotides linked to agarose via the nucleic acid base. The results are consistent with the view that the mitogenic response of thymocytes to nucleotides may be limited to as little as a single round of DNA synthesis and that such mitogenesis is stimulated at a site located on the plasma membrane. [ABSTRACT FROM AUTHOR]
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KW  - T cells
KW  - NUCLEOTIDES
KW  - ADENOSINE triphosphatase
KW  - GUANOSINE triphosphatase
KW  - LYMPHOCYTES
KW  - DNA synthesis
KW  - IMMUNOLOGY
N1  - Accession Number: 13965109; Gregory, S. H. 1,2 Kern, M. 1; Affiliation:  1: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205, U.S.A.  2: Department of Basic Science, Marquette University School of Dentistry, 604 North 16th Street, Milwaukee, Wisconsin 53233, U.S.A.; Source Info: Mar1981, Vol. 42 Issue 3, p451; Subject Term: T cells; Subject Term: NUCLEOTIDES; Subject Term: ADENOSINE triphosphatase; Subject Term: GUANOSINE triphosphatase; Subject Term: LYMPHOCYTES; Subject Term: DNA synthesis; Subject Term: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - SCHULZ, S. C.
AU  - VAN KAMMEN, D. P.
AU  - BALOW, J. E.
AU  - FLYE, M. W.
AU  - BUNNEY JR., W. E.
T1  - Dialysis in Schizophrenia: A Double-Blind Evaluation.
JO  - Science
JF  - Science
Y1  - 1981/03/06/
VL  - 211
IS  - 4486
M3  - Article
SP  - 1066
EP  - 1068
SN  - 00368075
AB  - Eight chronic schizophrenia patients completed a research program consisting of ten weekly sessions of active hemodialysis and ten weekly sessions of sham dialysis in a double-blind design. Previous reports of iherapeutic efficacy were not substantiated. None of the patients improved during active dialysis;four patients worsened. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88017612; SCHULZ, S. C. 1; VAN KAMMEN, D. P. 1; BALOW, J. E. 2; FLYE, M. W. 3; BUNNEY JR., W. E. 4; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20205; 3: Department of Surgery, University of Texas Medical Branch, Galveston 77550; 4: Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 3/ 6/1981, Vol. 211 Issue 4486, p1066; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - CHIANG, PETER K.
T1  - Conversion of 3T3-L1 Fibroblasts to Fat Cells by an Inhibitor of Methylation: Effect of 3-Deazaadenosine.
JO  - Science
JF  - Science
Y1  - 1981/03/13/
VL  - 211
IS  - 4487
M3  - Article
SP  - 1164
EP  - 1166
SN  - 00368075
AB  - 3-Deazaadenosine, an inhibitor of methylation, increased the frequency of conversion of 3T3-L1 fibroblasts to fat cells in a dose-dependent manner. Once converted, the 3T3-LI fat cells retained their adipose morphology and accumulated triglycerides even when 3-deazaadenosine was removed from the culture medium. 3-Deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3T3-Ll fibroblasts to fat cells. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948192; CHIANG, PETER K. 1; Affiliations: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 3/13/1981, Vol. 211 Issue 4487, p1164; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - LEWIS, MICHAEL E.
AU  - MISHKIN, MORTIMER
AU  - BRAGIN, EVGENI
AU  - BROWN, ROGER M.
AU  - PERT, CANDACE B.
AU  - PERT, AGU
T1  - Opiate Receptor Gradients in Monkey Cerebral Cortex: Correspondence with Sensory Processing Hierarchies.
JO  - Science
JF  - Science
Y1  - 1981/03/13/
VL  - 211
IS  - 4487
M3  - Article
SP  - 1166
EP  - 1169
SN  - 00368075
AB  - In order to obtain information on the possible functions of endogenous opiates in the primate cerebral cortex, we assessed the distribution of μ-like opiate receptors (which selectively bind 3H-labeled naloxone) and δ-like opiate receptors (which selectively bind 3H-labeled D-Ala2, D-Leu5-enkephalin) throughout the cerebral cortex of the rhesus monkey. Stereospecific [3H] naloxone binding sites increased in a gradient along hierarchically organized cortical systems that sequentially process modality-specific sensory information of a progressively more complex nature. Specific [3H]enkephalin binding sites, in contrast, were relatively evenly distributed throughout the cerebral cortex. These results, in combination with electrophysiological studies of monkeys and humans, suggest that μ-like opiate receptors may play a role in the affective filtering of sensory stimuli at the cortical level, that is, in emotion-induced selective attention. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948193; LEWIS, MICHAEL E. 1; MISHKIN, MORTIMER 2; BRAGIN, EVGENI 3; BROWN, ROGER M. 4; PERT, CANDACE B. 5; PERT, AGU 5; Affiliations: 1: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Section on Cerebral Mechanisms, Laboratory of Neuropsychology, National Institute of Mental Health; 3: Central Research Institute of Reflexotherapeutics, Moscow, U.S.S.R.; 4: Division of Research, National Institute on Drug Abuse, Rockville, Maryland 20857; 5: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 3/13/1981, Vol. 211 Issue 4487, p1166; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - ANFINSEN, CHRISTIAN B.
AU  - COURANT, ERNEST D.
AU  - FLORY, PAUL J.
AU  - PRIPSTEIN, MORRIS
AU  - RALSTON, ANTHONY
AU  - ILTIS, HUGH H.
AU  - COFFEY, JANICE C.
AU  - DENTON, MELINDA F.
T1  - U.S.-Soviet Relations.
JO  - Science
JF  - Science
Y1  - 1981/03/27/
VL  - 211
IS  - 4489
M3  - Article
SP  - 1369
EP  - 1373
SN  - 00368075
N1  - Accession Number: 88003270; ANFINSEN, CHRISTIAN B. 1; COURANT, ERNEST D. 2; FLORY, PAUL J. 3; PRIPSTEIN, MORRIS 4; RALSTON, ANTHONY 5; ILTIS, HUGH H. 6; COFFEY, JANICE C. 7; DENTON, MELINDA F. 8; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; 2: Brookhaven National Laboratory, Upton, New York 11973; 3: Stanford University, Stanford, California 94305; 4: Lawrence Berkeley Laboratory, University of California, Berkeley 94720; 5: State University of New York, Buffalo, Amherst 14226; 6: Department of Botany, University of Wisconsin, Madison 53706; 7: Department of Biology, St. Mary's College, Raleigh, North Carolina 27611; 8: Department of Botany, University of Washington, Seattle 98195; Issue Info: 3/27/1981, Vol. 211 Issue 4489, p1369; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - MERRIL, CARL R.
AU  - GOLDMAN, DAVID
AU  - SEDMAN, SYLVIA A.
AU  - EBERT, MICHAEL H.
T1  - Ultrasensitive Stain for Proteins in Polyacrylamide Gels Shows Regional Variation in Cerebrospinal Fluid Proteins.
JO  - Science
JF  - Science
Y1  - 1981/03/27/
VL  - 211
IS  - 4489
M3  - Article
SP  - 1437
EP  - 1438
SN  - 00368075
AB  - A new silver stain for electrophoretically separated polypeptides can be rapidly and easily used and can detect as little as 0.01 nanogram of protein per square millimeter. When employed with two-dimensional electrophoresis, it should permit qualitative and quantitative characterization of protein -distributions in body fluids and tissues. It has been used to demonstrate regional variations in cerebrospinal fluid proteins. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003303; MERRIL, CARL R. 1; GOLDMAN, DAVID 2; SEDMAN, SYLVIA A. 2; EBERT, MICHAEL H. 2; Affiliations: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 3/27/1981, Vol. 211 Issue 4489, p1437; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SKOLNICK, P.
AU  - MONCADA, V.
AU  - BARKER, J. L.
AU  - PAUL, S. M.
T1  - Pentobarbital: Dual Actions to Increase Brain Benzodiazepine Receptor Affinity.
JO  - Science
JF  - Science
Y1  - 1981/03/27/
VL  - 211
IS  - 4489
M3  - Article
SP  - 1448
EP  - 1450
SN  - 00368075
AB  - The binding of[³H]diazepam to benzodiazepine receptors was studied in extensively washed membranes of rat cerebral cortex in the presence of the depressant barbiturate, pentobarbital. Pentobarbital, like the endogenous neurotransmitter Ɣ-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of[³H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [³H]diazepam for the benzodiazepine receptor. The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these two types of compounds. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003308; SKOLNICK, P. 1; MONCADA, V. 1; BARKER, J. L. 2; PAUL, S. M. 3; Affiliations: 1: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health; 3: Clinical Psychobiology Branch, National Institute of Mental Health, National Institutes of Health; Issue Info: 3/27/1981, Vol. 211 Issue 4489, p1448; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Giambra, Leonard M.
T1  - DAYDREAMING, ATTENTIONAL PROCESSES, AND CURIOSITY IN WHITE AMERICANS: RELIGIOUS, EDUCATIONAL, ECONOMIC, AND RESIDENCY INFLUENCES FOR A LIFE SPAN SAMPLE.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1981/04//
VL  - 37
IS  - 2
M3  - Article
SP  - 262
EP  - 275
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article focuses on daydreaming, attentional processes and curiosity in White Americans. A sample of 580 white men and 773 white women 17-92 years old were scored on the 33 factors of the Imaginal Processes Inventory. Variables used in this study were obtained through responses to a Biographical Questionnaire. Because both age and sex differences have been shown to affect daydreaming significantly, any analyses that desire to demonstrate the effect of other demographic variables must control for the possible confounding effects of age and sex.
KW  - FANTASY
KW  - ATTENTION
KW  - CURIOSITY
KW  - WHITES
KW  - IMAGINATION
KW  - PSYCHOLOGY
N1  - Accession Number: 15845586; Giambra, Leonard M. 1,2; Affiliation:  1: Gerontology Research Center (Baltimore), National Institute on Aging, National Institutes of Health Bethesda.  2: Department of Health and Human Services and the Baltimore City Hospital., Baltimore, Maryland.; Source Info: Apr1981, Vol. 37 Issue 2, p262; Subject Term: FANTASY; Subject Term: ATTENTION; Subject Term: CURIOSITY; Subject Term: WHITES; Subject Term: IMAGINATION; Subject Term: PSYCHOLOGY; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tamaki, Kunihiko
AU  - Fujiwara, Hiromi
AU  - Katz, Stephen I.
T1  - The Role of Epidermal Cells in the Induction and Suppression of Contact Sensitivity.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/04//
VL  - 76
IS  - 4
M3  - Article
SP  - 275
EP  - 278
SN  - 0022202X
AB  - Haptens, such as trinitrochlorabenzene TNCB), bind to autologous skin proteins in the induction of allergic contact sensitivity. In order to clarify the role of epidermal cells in the induction of allergic contact sensitivity <em>in vivo,</em> we used trinitrobenzene sulfonate (TNBS)-conjugated epidermal cells (TNP-EC) in attempts to sensitize syngeneic mice. Spleen cells conjugate with TNBS (TNP-SC) were used for comparison. Four to 28 days after injection (via various routes) of the haptenated cells, contact sensitivity was assessed by the application of the same hapten to the ear. Sensitization regularly resulted form the subcutaneous injection of TNP-conjugated cells, and was longer lasting and was always stronger when TNP-EC were used rather than when TNP-SC were used. Neither TNP-EC nor TNP-SC injected intravenously resulted immunological hypo or unresponsiveness as assessed by subsequent painting with a sensitizing dose of TNCB. TNP-pvSC given intraperitoneally also did not sensitize when TNP-EC were given intraperitoneally. Both similarities and differences in the abilities of haptenated epidermal cells and spleen cells to induce sensitization and tolerance are described and the results are discussed in relation to the role of antigen-presenting cells contained in the haptenated cell populations. [ABSTRACT FROM AUTHOR]
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KW  - CONTACT dermatitis
KW  - PROTEINS
KW  - MICE
KW  - SPLEEN
KW  - INJECTIONS
KW  - ANTIGENS
N1  - Accession Number: 12526115; Tamaki, Kunihiko 1 Fujiwara, Hiromi 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology and Immunology Branches, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Apr81, Vol. 76 Issue 4, p275; Subject Term: CONTACT dermatitis; Subject Term: PROTEINS; Subject Term: MICE; Subject Term: SPLEEN; Subject Term: INJECTIONS; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12526115
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yaoita, Hideo
AU  - Briggaman, Robert A.
AU  - Lawley, Thomas J.
AU  - Provost, Thomas T.
AU  - Katz, Stephen I.
T1  - Epidermolysis Bullosa Acquisita: Ultrastructural and Immunological Studies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/04//
VL  - 76
IS  - 4
M3  - Article
SP  - 288
EP  - 292
SN  - 0022202X
AB  - Four patients with epidermolysis bullosa acquisita were investigated using immunofluorescence, routine electron microscopic and immunoelectron microscopic techniques. Immunofluorescence studies demonstrated linear immunoglobulin and complement deposition along the dermal-epidermal junction. These findings are similar to those seem in skin of patients with bullous acquisita from that seen in bullous pemphigoid. Indirect immunoelectron microscopic findings suggest that epidermal basal cells of affected patients may secrete the dermal substances to which the antibodies bind. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMOLYSIS bullosa
KW  - PATIENTS
KW  - IMMUNOFLUORESCENCE
KW  - SKIN
KW  - IMMUNOGLOBULINS
KW  - SECRETION
N1  - Accession Number: 12526124; Yaoita, Hideo 1 Briggaman, Robert A. 2 Lawley, Thomas J. 3 Provost, Thomas T. 4 Katz, Stephen I. 3; Affiliation:  1: Department of Dermatology University of Tsukuba Japan.  2: Department of Dermatology University of North Carolina, Chapel Hill North Carolina.  3: Department of Dermatology Branch, National Cancer Institute, Bethesda Maryland.  4: Department of Dermatology, John Hopkins University, Baltimore, Maryland, U.S.A.; Source Info: Apr81, Vol. 76 Issue 4, p288; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: PATIENTS; Subject Term: IMMUNOFLUORESCENCE; Subject Term: SKIN; Subject Term: IMMUNOGLOBULINS; Subject Term: SECRETION; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12526124
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12526124&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cordes, Rosemarie Selgas
AU  - Eddy, Joyce
AU  - Boyer, Marjorie
T1  - RN/MD TEAM-UP... WITH NO HASSLES.
JO  - RN
JF  - RN
Y1  - 1981/04//
VL  - 44
IS  - 4
M3  - Article
SP  - 58
EP  - 115
SN  - 00337021
AB  - Provides information on the team system approach of nurses and physicians at the medical Oncology Branch of the NCI-VA.  Progress of the team system; Basic plan of the hospital; Changes that were made for the team system approach.
KW  - TEAM nursing
KW  - HEALTH care teams
N1  - Accession Number: 5124694; Cordes, Rosemarie Selgas 1; Eddy, Joyce 1; Boyer, Marjorie 1; Source Information: Apr81, Vol. 44 Issue 4, p58; Subject: TEAM nursing; Subject: HEALTH care teams; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 1659
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2013-42219-019
AN  - 2013-42219-019
AU  - Yarrow, Leon J.
AU  - Zaslow, Martha
T1  - Review of The ecology of human development: Experiments by nature and design.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1981/04//
VL  - 51
IS  - 2
SP  - 363
EP  - 365
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42219-019. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Child and Family Research Branch, National Institute of Child Health and Human Development, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Ecological Factors; Experimental Design; Human Development; Theories. Minor Descriptor: Ecology. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Bronfenbrenner, Urie. The ecology of human development: Experiments by nature and design=330 pp. $16.50. Harvard University Press, Cambridge, Mass; 1979. Page Count: 3. Issue Publication Date: Apr, 1981. 
AB  - Reviews the book, The Ecology of Human Development: Experiments by Nature and Design by Urie Bronfenbrenner (1979). When Roger Barker began his ecological studies, he and his collaborators gave rich descriptions of children and adults in their natural settings. These finely embroidered pictures suggested the complexity of apparently simple everyday settings and events. In this book, Bronfenbrenner presents a theoretical perspective for ecological research on human development that differs in many ways from Barker's orientation. Three research paradigms are presented: studies of ecological transition, transforming experiments. and studies of contrasting environments. An important aspect of this book is Bronfenbrenner's critique of the laboratory as a context for observing human development. Bronfenbrenner gives evidence that the laboratory, as an unfamiliar and atypical context for both parents and children, evokes behavior that is different from behavior in natural contexts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - human development
KW  - ecology
KW  - experiment design
KW  - experiment nature
KW  - theoretical perspectives
KW  - 1981
KW  - Ecological Factors
KW  - Experimental Design
KW  - Human Development
KW  - Theories
KW  - Ecology
KW  - 1981
U2  - Bronfenbrenner, Urie. (1979); The ecology of human development: Experiments by nature and design; 330 pp. $16.50. Harvard University Press, Cambridge, Mass
DO  - 10.1037/h0098898
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - MAGNANI, JOHN L.
AU  - BROCKHAUS, MANFRED
AU  - SMITH, DAVID F.
AU  - GINSBURG, VICTOR
AU  - BLASZCZYK, MAGDALENA
AU  - MITCHELL, KENNETH F.
AU  - STEPLEWSKI, ZENON
AU  - KOPROWSKI, HILARY
T1  - A Monosialoganglioside Is a MonocIonal Anribody-Defined Antigen of Colon Carcinoma.
JO  - Science
JF  - Science
Y1  - 1981/04/03/
VL  - 212
IS  - 4490
M3  - Article
SP  - 55
EP  - 56
SN  - 00368075
AB  - The antigen of a monoclonal antibody that is specificfor cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-4abeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Antigens
KW  - Immunoglobulins
KW  - Colon cancer
KW  - Serum
KW  - Hybridomas
KW  - Cell lines
N1  - Accession Number: 84928437; MAGNANI, JOHN L. 1; BROCKHAUS, MANFRED 1; SMITH, DAVID F. 1; GINSBURG, VICTOR 1; BLASZCZYK, MAGDALENA 2; MITCHELL, KENNETH F. 2; STEPLEWSKI, ZENON 2; KOPROWSKI, HILARY 2; Affiliations: 1: National Institute of Arthritis, Metabolism, Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; Issue Info: 4/ 3/1981, Vol. 212 Issue 4490, p55; Thesaurus Term: Antigens; Subject Term: Immunoglobulins; Subject Term: Colon cancer; Subject Term: Serum; Subject Term: Hybridomas; Subject Term: Cell lines; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Negishi, Masahiko
AU  - Jensen, Nancy M.
AU  - Garcia, Gordon S.
AU  - Nebert, Daniel W.
T1  - Structural Gene Products of the Murine <em>Ali</em> Complex.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/04/15/
VL  - 115
IS  - 3
M3  - Article
SP  - 585
EP  - 594
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Antibodies against mouse-liver microsomal cytochromes P1-450 and P-448, two polycyclic aromatic-inducible cytochromes, were previously developed [Negishi, M. and Nebert, D. W. (1979) J. Riol. Chem. 254. 11015-110231]. Liver microsomes from 3-methylcholanthrene-treated and phenobarbital-treated and control adult mice and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated adult and fetal mice were examined. Immunoprecipitable radioactivity was measured, following labeling with pyridoxal phosphate/NaB[3H]4 or with 125I-labeled p-aminosulfohenzoie acid/NaNO2 in vitro or with [3H]leucine, [14C]glucosamine, or [32P]O4 in viva (a) Induction of cytochrome P1-450 occurs developmentally earlier in gestation titan induction of cytochrome P-448 when the mother is treated with polycyclic aromatic compounds. (b) There appears to be a basal form of cytochrome P-448 but no cytochrome P1-450 in control liver microsomes inducibility of cytochrome P-448 thus ranges between 5-12-fold, whereas that of P1-450 is infinite. (c) Phenobarbital pretreatment induces no detectable P1-450 or P-448. (d) P-448 appears to be either greater in concentration than P1-450 in the membrane or more exposed than P1-450 on the microsomal membrane surface. (c) By the radioimmunoassay methods used, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced P1-450 and P-448 in Ah-nonresponsive mice are indistinguishable from those in Ah-responsive mice; this is true in both the fetus and the adult. (f) Compared with P-448 expression, the expression of P1-450 is more closely associated with 3-methylcholanthrene-induced aryl hydrocarbon hydroxylase activity, and these two structural gene products are apparently regulated independently. (g) P-148 but not P1-450 appears to be a glycoprotein. These data illustrate further differences between two forms of polycyclic aromatic-inducible P50 in mouse liver. Neither P1-450 nor P-448 appears to be a phosphoprotein. Neither anti-(P1-450) nor anti-(P-448) precipitates any forms of liver microsomal P-450 from β-naphthoflavone-treated adult rabbits and, conversely. anti-LM4 (the antibody to rabbit liver microsomal P-450 form 4) does not precipitate any forms of liver microsomal P-450 from 3-methylcholanthrene-treated C57BL/6N mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENES
KW  - IMMUNOGLOBULINS
KW  - AMINO acids
KW  - PREGNANCY
KW  - LIVER
KW  - MICE
N1  - Accession Number: 13101409; Negishi, Masahiko 1 Jensen, Nancy M. 1 Garcia, Gordon S. 1 Nebert, Daniel W. 1; Affiliation:  1: Development Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda.; Source Info: 4/15/81, Vol. 115 Issue 3, p585; Subject Term: GENES; Subject Term: IMMUNOGLOBULINS; Subject Term: AMINO acids; Subject Term: PREGNANCY; Subject Term: LIVER; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goldhammer, Alan R.
AU  - Wolff, J.
AU  - Cook, G. Hope
AU  - Berkowitzt, Steven A.
AU  - Klee, Claude B.
AU  - Manclark, C. R.
AU  - Hewlett, Erik L.
T1  - Spurious Protein Activators of <em>Bordetella pertussis</em> Adenylated Cyclase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/04/15/
VL  - 115
IS  - 3
M3  - Article
SP  - 605
EP  - 609
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A variety of proteins and tissue preparations (rabbit erythrocyte lysate, catalase, peroxidase, creatine phosphokinase, and lima bean trypsin inhibitor) contain protein activator(s) of the extracellular adenylate cyclase of intact Bordetella pertussis organisms. Stimulation of adenylate cyclase activity of up to 1000-fold over basal activity can be obtained. Activation of the adenylate cyclase is due to the presence of calmodulin in these protein preparations. The criteria to establish this were: Ca2+ dependence of the activation, inhibition by trifluoperazine, heat stability of the activator, chromatographic behavior like authentic calmodulin, and stimulation of cyclic nucleotide phosphodiesterase by the activators The great sensitivity of the B. pertussis adenylate cyclase assay makes this and ideal system for the detection or trace amounts of calmodulin, in the presence of large amounts of other proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - BORDETELLA pertussis
KW  - PERTUSSIS toxin
KW  - PEROXIDASE
KW  - OXIDOREDUCTASES
KW  - TRYPSIN
N1  - Accession Number: 13101575; Goldhammer, Alan R. 1 Wolff, J. 1 Cook, G. Hope 1 Berkowitzt, Steven A. 1 Klee, Claude B. 1 Manclark, C. R. 1 Hewlett, Erik L. 1; Affiliation:  1: National lnstitutes of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda.; Source Info: 4/15/81, Vol. 115 Issue 3, p605; Subject Term: PROTEINS; Subject Term: BORDETELLA pertussis; Subject Term: PERTUSSIS toxin; Subject Term: PEROXIDASE; Subject Term: OXIDOREDUCTASES; Subject Term: TRYPSIN; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Resch, Klaus
AU  - Wood, Theodore
AU  - Northoff, Hinnak
AU  - Cooper, Herbert L.
T1  - Microtubules: Are They Involved in the Initiation of Lymphocyte Activation?
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/04/15/
VL  - 115
IS  - 3
M3  - Article
SP  - 659
EP  - 664
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Purified human blood lymphocytes were stimulated with concanavalin A or phytohemagglutinin. DNA synthesis was measured with 2-h pulses of [3H)thymidine between 48 h and 73 h after stimulation. Colchicine, at concentrations between 0.1 μM and 10 μM, suppressed consequent DNA synthesis without affecting viability of the cells when added at any time up to 18 h before incorporation of [3thymidine was assessed. In concanavalin-A-stimulated lymphocytes, removal of the mitogen by methyl α-mannoside only prevented proliferation when added initially, hut was without any effect when added after 20 h of stimulation, regardless of when DNA synthesis was measured. Thus, there was a period after 20 h of concanavalin A stimulation, when DNA synthesis was still sensitive to colchicine, but no longer required the presence of the mitogen. Colchicine also suppressed incorporation of [3H]leucine into protein, in resting as well as mitogen-stimulated lymphocytes. Similarly, colchicine decreased amino acid transport, as determined by uptake of α-amino-isobutyrate, which appeared to be the rate-limiting step in the incorporation of amino acids into protein in colchicine-treated cells. When the rate of protein synthesis was followed by the relative distribution of ribosomal particles, especially the increase of polysomes in activated lymphocytes, colchicine was without any detectable effect. The early increase in the incorporation of [14C]oleate into phospholipids was identical in the presence or absence of the microtubule-active drug. The data strongly suggest that microtubule are not involved in the initiation of lymphocyte growth or mitogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLOOD
KW  - LYMPHOCYTES
KW  - PHYTOHEMAGGLUTININS
KW  - PLANT lectins
KW  - AMINO acids
KW  - RIBOSOMES
N1  - Accession Number: 13101657; Resch, Klaus 1,2,3 Wood, Theodore 1,2,3 Northoff, Hinnak 1,2,3 Cooper, Herbert L. 1,2,3; Affiliation:  1: Cellular and Molecular Physiology Section, Laboratory of Pathophysiology, National Institutes of Health, Bethesda.  2: Institut für Virusforsehung, Deutsches Krebsforschungszentrum, Heidelberg.  3: Institut für Immunologie der Universität, Heidelberg.; Source Info: 4/15/81, Vol. 115 Issue 3, p659; Subject Term: BLOOD; Subject Term: LYMPHOCYTES; Subject Term: PHYTOHEMAGGLUTININS; Subject Term: PLANT lectins; Subject Term: AMINO acids; Subject Term: RIBOSOMES; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wahli, Walter
AU  - Dawid, Igor B.
AU  - Ryffel, Gerhart U.
AU  - Weber, Rudolf
T1  - Vitellogenesis and the Vitellogenin Gene Family.
JO  - Science
JF  - Science
Y1  - 1981/04/17/
VL  - 212
IS  - 4492
M3  - Article
SP  - 298
EP  - 304
SN  - 00368075
N1  - Accession Number: 88003359; Wahli, Walter 1,2; Dawid, Igor B. 1; Ryffel, Gerhart U.; Weber, Rudolf 3; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Institut de Biologie Animale, University de Lausanne, CH-1005 Lausanne, Switzerland. G. U. Ryffel; 3: Department of Zoology, University of Bern, CH- 3012 Bern, Switzerland; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p298; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BROWNSTEIN, MICHAEL J.
T1  - Neuroendocrinology.
JO  - Science
JF  - Science
Y1  - 1981/04/17/
VL  - 212
IS  - 4492
M3  - Article
SP  - 320
EP  - 320
SN  - 00368075
N1  - Accession Number: 88003374; BROWNSTEIN, MICHAEL J. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p320; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NAGAO, KENJI
AU  - YOKORO, KENJIRO
AU  - AARONSON, STUART A.
T1  - Continuous Lines of Basophil/Mast Cells Derived from Normal Mouse Bone Marrow.
JO  - Science
JF  - Science
Y1  - 1981/04/17/
VL  - 212
IS  - 4492
M3  - Article
SP  - 333
EP  - 335
SN  - 00368075
AB  - Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophillmast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation as well as the differentiation pathways involving this subset of hematopoietic cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003382; NAGAO, KENJI 1; YOKORO, KENJIRO 2; AARONSON, STUART A. 3; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima 730, Japan; 3: Laboratory of Cellular and Molecular Biology, National Cancer Institute; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p333; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARKER, JEFFERY L.
AU  - MATHERS, DAVID A.
T1  - GABA Analogues Activate Channels of Different Duration on Cultured Mouse Spinal Neurons.
JO  - Science
JF  - Science
Y1  - 1981/04/17/
VL  - 212
IS  - 4492
M3  - Article
SP  - 358
EP  - 361
SN  - 00368075
AB  - Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to -y-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003393; BARKER, JEFFERY L. 1,2; MATHERS, DAVID A. 1,2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological; 2: Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p358; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DEAN, ANN
AU  - ERARD, FRANCOIS
AU  - SCHNEIDER, ARTHUR B.
AU  - SCHECHTER, ALAN N.
T1  - Induction of Hemoglobin Accumulation in Human K562 Cells by Hemin Is Reversible.
JO  - Science
JF  - Science
Y1  - 1981/04/24/
VL  - 212
IS  - 4493
M3  - Article
SP  - 459
EP  - 461
SN  - 00368075
AB  - Twenty micromolar hemin causes no change in the rate of division of K562 cells but results in accumulation of 11 to 14 picograms of embryonic and fetal hemoglobins per cell. This effect is reversible, and hemoglobin induction in response to hemin, and loss of hemoglobin upon removal of hemin, can be cyclically repeated. The cells can be indefinitely subcultured in the presence of the inducer. Thus, the control of hemoglobin levels in 1562 cells does not depend on irreversible differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84928492; DEAN, ANN 1; ERARD, FRANCOIS 1; SCHNEIDER, ARTHUR B. 1,2; SCHECHTER, ALAN N. 1; Affiliations: 1: Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Michael Reese Hospital, University of Chicago, Chicago, Ill. 60616; Issue Info: 4/24/1981, Vol. 212 Issue 4493, p459; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Fredrickson, Donald S.
AU  - Bertrand, Anson
T1  - Federally supported human nutrition research, training, and education.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1981/05//
VL  - 34
IS  - 5
M3  - Article
SP  - 957
EP  - 958
SN  - 00029165
N1  - Accession Number: 94381407; Fredrickson, Donald S. 1; Bertrand, Anson 2; Affiliations: 1: Director, National Institutes of Health, DHHS, Chairman, Committee on Health and Medicine; 2: Administrator, Science and Education Administration, USDA, Chairman, Committee on Food and Renewable Resources; Issue Info: May1981, Vol. 34 Issue 5, p957; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Berman, J. D.
AU  - Dwyer, D. M.
T1  - Expression of Leishmania antigen on the surface membrane of infected human macrophages <em>in vitro</em>.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/05//
VL  - 44
IS  - 2
M3  - Article
SP  - 342
EP  - 348
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Resolution of leishmaniasis is associated with host immunological responsiveness to parasite antigens. In clinical disease. Leishmania are found as amastigoles contained within macrophages. We investigated the possibility that Leishmania antigens arc expressed on the infected macrophage surface by reacting infected macrophages with antibody to Leishmania. In Vitro-infected human monocyte-derived macrophages were labelled with antibody lo amastigotes when examined with immunofluorescent or immunoelectron microscopic techniques. Infected macrophages were poorly labelled by antibody to promastigotes (insect forms of Leishmania). Certain antisera that reacted with the surface membranes of amastigotes did not label the infected macrophage surface. These results indicate that human macrophages infected in vitro express Leishmania amastigote antigen(s) on their surface membranes, that such antigen(s)may not be present in large quantities in promastigotes and that certain antigen(s) on the amastigote surface are not expressed on the surface membranes of infected macrophages. [ABSTRACT FROM AUTHOR]
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KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - LEISHMANIASIS
KW  - IMMUNE serums
KW  - MACROPHAGES
KW  - KILLER cells
N1  - Accession Number: 15944844; Berman, J. D. 1 Dwyer, D. M. 1; Affiliation:  1: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA.; Source Info: May1981, Vol. 44 Issue 2, p342; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: LEISHMANIASIS; Subject Term: IMMUNE serums; Subject Term: MACROPHAGES; Subject Term: KILLER cells; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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TY  - JOUR
AU  - Yaar, Mina
AU  - Stanley, John R.
AU  - Katz, Stephen I.
T1  - Retinoic Acid Delays the Terminal Differentiation of Keratinocytes in Suspension Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/05//
VL  - 76
IS  - 5
M3  - Article
SP  - 363
EP  - 366
SN  - 0022202X
AB  - The effect of retinoic acid (RA) on the terminal differentiation of guinea pig keratinocytes maintained in suspension culture was studied. Keratinocytes obtained from trypsinized guinea pig skin were suspended in medium containing 20% calf serum and 1.2% methyl cellulose. RA, which was added at the beginning of culture, delayed differentiation as judged by a decrease in the percent of cells that developed disulfide cross-linked keratin (sodium dodecyl sulfate insoluble cells) and cornified envelopes (sodium dodecyl sulfate and 2-mercaptoethanol insoluble cells). RA inhibited differentiation maximally at 5 μg/ml on day 3 of a 5 day culture; concentrations as low as .005 μg/ml were also inhibitory. Because the disulfide cross-linking of keratin and the formation of cornified envelopes are thought to occur when the cell membrane becomes permeable, we determined whether RA inhibited these processes by stabilizing the cell membrane. Two agents (ionophore X537A and Triton X-100) which permeabilize cell membranes rapidly reversed the inhibitory effect of RA on cornified envelope formation. In addition, when cultured with RA, the percent of cells which became permeable to trypan blue was reduced, also suggesting that RA acts on the cell membrane. These studies show that RA can inhibit keratinocyte differentiation by stabilizing the cell membrane thereby delaying transition from a living epidermal cell to a dead cornified cell. [ABSTRACT FROM AUTHOR]
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KW  - TRETINOIN
KW  - KERATINOCYTES
KW  - SKIN tests
KW  - CELLULOSE
KW  - CELL membranes
KW  - KERATIN
N1  - Accession Number: 12520026; Yaar, Mina 1 Stanley, John R. 1,2 Katz, Stephen I. 2; Affiliation:  1: Laboratory of Developmental Biology and Anomalies of the National Institute of Dental Research, Bethesda, Maryland, U.S.A.  2: Dermatology Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May81, Vol. 76 Issue 5, p363; Subject Term: TRETINOIN; Subject Term: KERATINOCYTES; Subject Term: SKIN tests; Subject Term: CELLULOSE; Subject Term: CELL membranes; Subject Term: KERATIN; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12520026
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TY  - JOUR
AU  - RESNICK, M. A.
AU  - KASIMOS, J. N.
AU  - GAME, J. C.
AU  - BRAUN, R. J.
AU  - ROTH, R. M.
T1  - Changes in DNA During Meiosis in a Repair-Deficient Mutant (rad 52) of Yeast.
JO  - Science
JF  - Science
Y1  - 1981/05//5/ 1/1981
VL  - 212
IS  - 4494
M3  - Article
SP  - 543
EP  - 545
SN  - 00368075
AB  - The kinetic patterns ofDNA synthesis in vild-type (RAD+) and rad 52 mutants of yeast, which exhibit high levels of synchrony during meiosis, are comparable. However, RAD 52 mutants accumulate single-strand breaks in parental DNA during the DNA synthesis period. Thus, the product of the RAD 52 gene has a role in meiotic DNA metabolism, as well as in the repair of DNA damage during mitotic growth. The observed breaks may be unresolved recombination intermediates. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84928549; RESNICK, M. A. 1; KASIMOS, J. N. 2; GAME, J. C. 3; BRAUN, R. J. 4; ROTH, R. M. 4; Affiliations: 1: National Institute of Environmental Health Sciences, Laboratory of Molecular Genetics, Research Triangle Park, North Carolina 27709; 2: Department of Biology, illinois Institute of Technology, Chicago 60616; 3: Department of Genetics, University of California, Berkeley 94720; 4: Department of Biology, Illinois Institute of Technology; Issue Info: 5/ 1/1981, Vol. 212 Issue 4494, p543; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - KAPLAN, ANN E.
AU  - WEISS, ELLEN R.
AU  - BYRNE, SHARON T.
AU  - EL-TORKEY, NABIL M.
AU  - MARGOLIS, SAM A.
T1  - Purified Reduced Nicotinamide Adenine Dinucleotide: Responses to Lactate Dehydrogenase Isozymes from Three Cell Sources.
JO  - Science
JF  - Science
Y1  - 1981/05//5/ 1/1981
VL  - 212
IS  - 4494
M3  - Article
SP  - 553
EP  - 555
SN  - 00368075
AB  - Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinicleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purifiedfrom rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not accouint for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The resullts suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84928554; KAPLAN, ANN E. 1; WEISS, ELLEN R. 1; BYRNE, SHARON T. 1; EL-TORKEY, NABIL M. 1; MARGOLIS, SAM A. 2; Affiliations: 1: Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, Maryland 20205; 2: Organic Analytical Research Division, Center for Analytical Chemistry, National Bureau of Standards, Washington, D.C. 20234; Issue Info: 5/ 1/1981, Vol. 212 Issue 4494, p553; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Hemmings, Brian A.
T1  - Reactivation of the Phospho Form of the NAD-Dependent Glutamate Dehydrogenase by a Yeast Protein Phosphatase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/05/02/
VL  - 116
IS  - 1
M3  - Article
SP  - 47
EP  - 50
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A protein phosphatase was isolated from the yeast, Candida utilities, which could reactivate (dephosphorylate) the phosphorylated form of the NAD-dependent glutamate dehvdrogenase. The protein could also dephosphory1ate casein, histone and kemptide (a heptapeptide corresponding to the phosphorylation site of liver pyruvate kinase).Reactivation of the phosphorylated glutamate dehydrogenase was stimulated by the simultaneous addition of NAD and L-glutamate; 2-oxoglutarate, NH4+ and NADH had no effect. The reactivation of phosphorylated glutamate dehydrogenase could be inhibited by phosphate, pyrophosphate and fluoride. [ABSTRACT FROM AUTHOR]
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KW  - YEAST
KW  - GLUTAMATE dehydrogenase
KW  - DEHYDROGENASES
KW  - CANDIDA
KW  - BIOCHEMISTRY
KW  - MEDICAL sciences
N1  - Accession Number: 13924740; Hemmings, Brian A. 1; Affiliation:  1: Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda; Source Info: 5/2/81, Vol. 116 Issue 1, p47; Subject Term: YEAST; Subject Term: GLUTAMATE dehydrogenase; Subject Term: DEHYDROGENASES; Subject Term: CANDIDA; Subject Term: BIOCHEMISTRY; Subject Term: MEDICAL sciences; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - HAASE, A. T.
AU  - VENTURA, P.
AU  - GIBBS JR., C. J.
AU  - TOURTELLOTTE, W. W.
T1  - Measles Virus Nucleotide Sequences: Detection by Hybridization in situ.
JO  - Science
JF  - Science
Y1  - 1981/05/08/
VL  - 212
IS  - 4495
M3  - Article
SP  - 672
EP  - 675
SN  - 00368075
AB  - A tritium-labeled probe that detects measles virus nucleotide sequences was hybridized in situ to cells infected with measles virus and to sections of brain tissue from patients with subacute sclerosing panencephalitis and from patients with multiple sclerosis. The measles virus genome was detected in many cells in subacute sclerosing panencephalitis where this virus would have been missed by methods such as immunofluorescence. Measles virus sequences were also found in two foci in one of four cases of multiple sclerosis. This refined method of hybridization in situ, which can be useful in the search for covert virus infections of man, provides evidence that viruses may be involved in multiple sclerosis. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003424; HAASE, A. T. 1; VENTURA, P. 1; GIBBS JR., C. J. 2; TOURTELLOTTE, W. W. 3,4; Affiliations: 1: Veterans Administration Medical Center and University of California, San Francisco 94121; 2: National Institutes of Health, Bethesda, Maryland 20205; 3: Neurology and Research Services, Veterans Administration, Wadsworth Medical Center, Los Angeles, California 90073; 4: Department of Neurology, University of California, Los Angeles 90073; Issue Info: 5/ 8/1981, Vol. 212 Issue 4495, p672; Number of Pages: 4p; Document Type: Article
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TY  - JOUR
AU  - HUNNINGHAKE, G. W.
AU  - DAVIDSON, J. M.
AU  - RENNARD, S.
AU  - SZAPIEL, S.
AU  - GADEK, J. E.
AU  - CRYSTAL, R. G.
T1  - Elastin Fragments Attract Macrophage Precursors to Diseased Sites in Pulmonary Emphysema.
JO  - Science
JF  - Science
Y1  - 1981/05/22/
VL  - 212
IS  - 4497
M3  - Article
SP  - 925
EP  - 927
SN  - 00368075
AB  - This study suggests one mechanism by which alveolar macrophages accumulate in the lung in pulmonary emphysema: elastin fragments generated at the diseased sites are potent chemoattractants for monocytes, the precursors of the macrophages. The most chemotactic elastin fragments have a molecular weight between 10,000 and 50,000 and are active at concentrations as low as 3 nanograms per milliliter. By comparison, elastin fragments with higher molecular weights and desmosines are active only at concentrations greater than 0.3 microgram per milliliter. In addition, preincubation of monocytes with the 10,000- to 50,000-dalton elastin impairs the ability of the cells to migrate toward elastin fragments but not toward activated serum. Fragments of tropoelastin are not chemotactic for monocytes. Because elastin, but not tropoelastin, contains lysyl-derived cross-links, these structures may be the active chemotactic site on the elastin fragments. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948237; HUNNINGHAKE, G. W. 1; DAVIDSON, J. M. 1; RENNARD, S. 1; SZAPIEL, S. 1; GADEK, J. E. 1; CRYSTAL, R. G. 1; Affiliations: 1: Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p925; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - GOTTLIEB, MICHAEL
AU  - DWYER, DENNIS M.
T1  - Protozoan Parasite of Humans: Surface Membrane with Externally Disposed Acid Phosphatase.
JO  - Science
JF  - Science
Y1  - 1981/05/22/
VL  - 212
IS  - 4497
M3  - Article
SP  - 939
EP  - 941
SN  - 00368075
AB  - Plasma membranes isolated from the protozoan parasite Leishmania donovani were enriched in acid phosphatase (E.C. 3.1.3.2) activity. Cytochemically, the enzyme was distributed uniformly on the surface of intact cells and was localized on the externalface of isolated membranes. Physical characteristics and orientation of the membrane-bound enzyme suggest that the organism is adapted for existence in hydrolytic environments. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948243; GOTTLIEB, MICHAEL 1; DWYER, DENNIS M. 2; Affiliations: 1: Department of Pathobiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205; 2: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p939; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - BLAIR, D. G.
AU  - OSKARSSON, M.
AU  - WOOD, T. G.
AU  - McCLEMENTS, W. L.
AU  - FISCHINGER, P. J.
AU  - VAN DE WOUDE, G. G.
T1  - Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis.
JO  - Science
JF  - Science
Y1  - 1981/05/22/
VL  - 212
IS  - 4497
M3  - Article
SP  - 941
EP  - 943
SN  - 00368075
AB  - The molecularly cloned, long terminal repeat (LTR) of the Moloney sarcoma virus (M-MSV) provirus has been covalently linked to c-mos, the cellular homolog of the M-MSV-specific sequence, v-mos. These newly constructed clones lack any M-MSV-derived sequences other than the LTR, but in DNA transfection assays they transform cells as efficiently as cloned subgenomic M-MSV fragments containing both v-mos and LTR. Cells transformed by LTR:c-mos hybrid molecules contain additional copies of mos DNA, and several size classes of polyadenylated RNA's with sequence homology to mos. The activation of the transforming potential of c-mos by the proviral LTR suggests a model whereby LTR-like elements could activate other normal cell sequences with oncogenic potential. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948244; BLAIR, D. G. 1; OSKARSSON, M. 2; WOOD, T. G. 2; McCLEMENTS, W. L. 2; FISCHINGER, P. J. 3; VAN DE WOUDE, G. G. 4; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21701; 2: Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory of Viral Carcinogenesis, National Cancer Institute; 4: Laboratory of Molecular Virology, National Cancer Institute; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p941; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KAPATOS, GREGORY
AU  - KAUFMAN, SEYMOUR
T1  - Peripherally Administered Reduced Pterins Do Enter the Brain.
JO  - Science
JF  - Science
Y1  - 1981/05/22/
VL  - 212
IS  - 4497
M3  - Article
SP  - 955
EP  - 956
SN  - 00368075
AB  - The content of tetrahydrobiopterin in rat brain was doubled by peripherally administered tetrahydrobiopterin, with the natural 1 diastereoisomer more effective than the unnatural d configuration. The model pteridine, 6-methyltetrahydropterin was ten times more efficient than tetrahydrobiopterin in crossing the bloodbrain barrier, and striatal concentrations of 6-methyltetrahydropterin remained elevated for 2 hours, declining with a half-life of 3 hours. While no evidence for a specific uptake mechanism for concentrating 6-methyltetrahydropterin in cells containing tetrahydrobiopterin was detected, the pterin was found in its presumed site of action, the nerve terminal. Replacement therapy with reduced pterins may therefore be effective in the treatment of the neurological disorders associated with the variantforms of hyperphenylalaninemia that resultfrom defects in the biosynthesis or metabolism of tetrahydrobiopterin within the central nervous system. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84948250; KAPATOS, GREGORY 1; KAUFMAN, SEYMOUR; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p955; Number of Pages: 2p; Document Type: Article
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TY  - JOUR
AU  - WASKOW, IRENE ELKIN
AU  - PARLOFF, MORRIS P.
AU  - OSTOW, MORTIMER
AU  - STRUPP, HANS H.
AU  - DAWES, ROBYN M.
T1  - Depression Study.
JO  - Science
JF  - Science
Y1  - 1981/05/29/
VL  - 212
IS  - 4498
M3  - Article
SP  - 984
EP  - 986
SN  - 00368075
N1  - Accession Number: 88003437; WASKOW, IRENE ELKIN 1; PARLOFF, MORRIS P. 2; OSTOW, MORTIMER; STRUPP, HANS H. 3; DAWES, ROBYN M. 4,5; Affiliations: 1: Psychotherapy of Depression Collaborative Research Program, National Institute of Mental Health, Rockville, Maryland 20857; 2: Psychotherapy Research Branch, National Institute of Mental Health; 3: Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240; 4: Center for Advanced Study, Behavioral Sciences, Stanford, California 94305; 5: Department of Psychology, University of Oregon, Eugene 97403; Issue Info: 5/29/1981, Vol. 212 Issue 4498, p984; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - TULLY, JOSEPH G.
AU  - ROSE, DAVID L.
AU  - YUNKER, CONRAD E.
AU  - CORY, JACK
AU  - WHITCOMB, ROBERT F.
AU  - WILLIAMSON, DAVID L.
T1  - Helical Mycoplasmas (Spiroplasmas) from Ixodes Ticks.
JO  - Science
JF  - Science
Y1  - 1981/05/29/
VL  - 212
IS  - 4498
M3  - Article
SP  - 1043
EP  - 1045
SN  - 00368075
AB  - A new spiroplasma isolated from Ixodes pacificus collected in Oregon was serologically and morphologically distinct from known spiroplasmas. The new spiroplasma could also be isolated in tick cell cultures. Discovery of a newfastidious mycoplasma in ticks of fers opportunities to explore the possible role of these agents in human and animal diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003473; TULLY, JOSEPH G. 1; ROSE, DAVID L. 1; YUNKER, CONRAD E. 2; CORY, JACK 2; WHITCOMB, ROBERT F. 3; WILLIAMSON, DAVID L. 4; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Epidemiology Branch, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 3: Insect Pathology Laboratory, Plant Protection Institute, SEA-AR, U.S. Department of Agriculture, Beltsville, Maryland 20705; 4: Department of Anatomical Sciences, State University of New York, Stony Brook 11794; Issue Info: 5/29/1981, Vol. 212 Issue 4498, p1043; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ESKAY, R. L.
AU  - FURNESS, J. F.
AU  - LONG, R. T.
T1  - Substance P Activity in the Bullfrog Retina: Localization and Identification in Several Vertebrate Species.
JO  - Science
JF  - Science
Y1  - 1981/05/29/
VL  - 212
IS  - 4498
M3  - Article
SP  - 1049
EP  - 1051
SN  - 00368075
AB  - Immunoreactive substance P is present in the bullfrog retina, possibly in two types of stratified amacrine cells, with their somas in the inner nuclear layer and their neuronal processes entering the inner plexiform layer and ramifying in sublayers 3 or 4 (or both). Occasionally, polygonal somas positive for substance P were found in the ganglion cell layer. Approximately 75 percent of the cell bodies positive for substance P and 65 percent of the radioimmunoassayable substance P were found in the superior half of the frog retina. On the basis of high-performance liquid chromatography, the immunoreactive substance P in the neural retina of the rat, monkey, or chick is similar to synthetic substance P, whereas this is not true of the immunoreactive substance P in the bullfrog or carp retina. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003476; ESKAY, R. L. 1; FURNESS, J. F. 1; LONG, R. T. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 5/29/1981, Vol. 212 Issue 4498, p1049; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Simopoulos, Artemis P.
T1  - Highlights of the National Institutes of Health Program in Biomedical and Behavioral Nutrition and Research Training--with the emphasis on total parenteral and enteral nutrition.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1981/06//
VL  - 34
IS  - 6
M3  - Article
SP  - 1187
EP  - 1190
SN  - 00029165
N1  - Accession Number: 94406781; Simopoulos, Artemis P. 1; Affiliations: 1: Chairman, NIH-Nutrition Coordinating Committee, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: Jun1981, Vol. 34 Issue 6, p1187; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Costas Jr., Raul
AU  - Garcia-Palmieri, Mario R.
AU  - Sorlie, Paul
AU  - Hertzmark, Ellen
T1  - Coronary Heart Disease Risk Factors in Men With Light and Dark Skin in Puerto Rico.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1981/06//
VL  - 71
IS  - 6
M3  - Article
SP  - 614
EP  - 619
PB  - American Public Health Association
SN  - 00900036
AB  - The association of skin color with coronary heart disease risk factors was studied in 4,000 urban Puerto Rican men, Skin color on the inner upper arm was classified according to the von Luschan color tiles. Using this grading, men were separated into two groups of light or dark skin color. The dark group had a lower socioeconomic status (SES) based on income, education, and occupation. Dark men had slightly higher mean systolic blood pressures (SBP) and lower mean serum cholesterol levels than the light, but the relative weights and cigarette smoking habits of both groups were similar. After controlling for the differences in SES, skin color showed a small but statistically significant association with SBP. Whether this association with skin color represents genetic or environmental influences on SBP could not be determined from this study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORONARY heart disease
KW  - HUMAN skin color
KW  - SOCIOECONOMIC factors
KW  - MEN
KW  - PUERTO Rico
N1  - Accession Number: 4948982; Costas Jr., Raul 1 Garcia-Palmieri, Mario R. 1 Sorlie, Paul 2 Hertzmark, Ellen 1; Affiliation:  1: Department of Medicine, School of Medicine, University of Puerto Rico, San Juan, PR  2: Health Statistician, Biometrics Research Branch, National Heart, Lung, and Blood Institute, Federal Building, Room 2A06, Bethesda, MD 20205; Source Info: Jun81, Vol. 71 Issue 6, p614; Subject Term: CORONARY heart disease; Subject Term: HUMAN skin color; Subject Term: SOCIOECONOMIC factors; Subject Term: MEN; Subject Term: PUERTO Rico; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Brody, Jacob A.
T1  - Dr. Brody's Response.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1981/06//
VL  - 71
IS  - 6
M3  - Letter
SP  - 650
EP  - 650
PB  - American Public Health Association
SN  - 00900036
AB  - A reply by Jacob A. Brody to two letters to editor about his article "Manning the Battlements of Research Epidemiology," published in a 1981 issue, is presented.
KW  - LETTERS to the editor
KW  - EPIDEMIOLOGY
N1  - Accession Number: 22492749; Brody, Jacob A. 1; Affiliation:  1: Associate Director for Epidemiology, Demography, and Biometry Program, National Institute on Aging, DHHS, PHS, NIH, Bethesda, MD 20205; Source Info: Jun81, Vol. 71 Issue 6, p650; Subject Term: LETTERS to the editor; Subject Term: EPIDEMIOLOGY; Number of Pages: 1/4p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Moment, Gairdner B.
T1  - RISK MONEY FOR RESEARCH AND THE PEER REVIEW SYSTEM.
JO  - BioScience
JF  - BioScience
Y1  - 1981/06//
VL  - 31
IS  - 6
M3  - Editorial
SP  - 421
EP  - 421
SN  - 00063568
AB  - The article comments on the peer review system for awarding grants which slows down scientific advancement. It informs that both the U.S. National Science Foundation and National Institutes of Health have studied the possibility of bias based on sex or race and for or against Ivy League institutions or investigators. It reports that according to a survey, granting officers agreed that an average panel member is reluctant to recommend proposals that stray very far from the usual path.
KW  - Research grants
KW  - Peer review (Professional performance)
KW  - United States
KW  - National Science Foundation (U.S.)
N1  - Accession Number: 28051170; Moment, Gairdner B. 1; Affiliations: 1 : Professor of Biology Emeritus, Coucher College Guest Scientist, National Institute on Aging Gerontology Research Center Baltimore, MD 21224;  Source Info: Jun1981, Vol. 31 Issue 6, p421; Subject Term: Research grants; Subject Term: Peer review (Professional performance); Subject: United States; Number of Pages: 2/3p; Document Type: Editorial; Full Text Word Count: 848
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Yarosh, Daniel B.
T1  - STUDYING MACROMOLECULES.
JO  - BioScience
JF  - BioScience
Y1  - 1981/06//
VL  - 31
IS  - 6
M3  - Book Review
SP  - 458
EP  - 458
SN  - 00063568
AB  - The article reviews the book "Introduction of Macromolecules Into Viable Mammalian Cells," Vol. 1, "Wistar Symposium Series," edited by Renato Baserga, Carlo Croce and Giovanni Rovera.
KW  - Macromolecules
KW  - Nonfiction
KW  - Baserga, Renato
KW  - Croce, Carlo
KW  - Rovera, Giovanni
KW  - Introduction of Macromolecules Into Viable Mammalian Cells: Wistar Symposium Series (Book)
N1  - Accession Number: 28051182; Yarosh, Daniel B. 1; Affiliations: 1 : National Cancer Institute, NIH Building 37, Room 3c21, Bethesda, MD 20205;  Source Info: Jun1981, Vol. 31 Issue 6, p458; Subject Term: Macromolecules; Subject Term: Nonfiction; Number of Pages: 2/3p; Document Type: Book Review; Full Text Word Count: 684
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Nagel, J. E.
AU  - Chrest, F. J.
AU  - Adler, W. H.
T1  - Human B cell function in normal individuals of various ages.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/06//
VL  - 44
IS  - 3
M3  - Article
SP  - 646
EP  - 653
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The effect of age on the in vitro generation of immunoglobulin-secreting cells in pokeweed mitogen-stimulated cultures was examined using a staphylococcal protein A plaque assay. Although there was no statistically significant decrease with age in the numbers of plaque-forming cells, subjects whose cells failed to produce immunoglobulin were four times more common amongst individuals over 55 years of age. Simultaneously-measured I and B lymphocyte numbers, 3H-thymidine incorporation by mitogen-stimulated cultures, and serum immunoglobulins were comparable in both the young and the aged. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - B cells
KW  - IMMUNOGLOBULINS
KW  - OLD age
KW  - STAPHYLOCOCCAL protein A
KW  - THYMIDINE
KW  - PATIENTS
N1  - Accession Number: 16253473; Nagel, J. E. 1 Chrest, F. J. 1 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.; Source Info: Jun1981, Vol. 44 Issue 3, p646; Subject Term: B cells; Subject Term: IMMUNOGLOBULINS; Subject Term: OLD age; Subject Term: STAPHYLOCOCCAL protein A; Subject Term: THYMIDINE; Subject Term: PATIENTS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Baum, Bruce J.
T1  - Characteristics of participants in the oral physiology component of the Baltimore longitudinal study of aging.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1981/06//
VL  - 9
IS  - 3
M3  - Article
SP  - 128
EP  - 134
SN  - 03015661
AB  - This report describes a variety of demographic, socioeconomic and dental characteristics of 254 (145 male, 109 female) participants in a longitudinal study of oral physiology and aging. All individuals are part of the U.S. National Institute on Aging's Baltimore Longitudinal Study of Aging. Subjects are generally in middle to upper middle socioeconomic strata, well educated and in good health (about 75% not taking prescription medication). Most participants practice regular oral hygiene habits and receive regular and comprehensive dental care. Less than 4% of all subjects are edentulous and the average number of natural teeth present for all participants was about 23. Data are presented on DMFT scores, cervical caries (active and restored) scores and gingival and periodontal disease indices for males by age group (20-39, 40-59, 60-88 years) and for females by menopause status (pre-, post-). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL care
KW  - GUM disease
KW  - PERIODONTAL disease
KW  - PERIODONTICS
KW  - AGING
KW  - TEETH -- Care & hygiene
KW  - aging
KW  - dental care
KW  - dental status
KW  - gingival disease
KW  - oral physiology
KW  - periodontal disease.
N1  - Accession Number: 12096155; Baum, Bruce J. 1; Affiliation:  1: Laboratory of Molecular Aging, Gerontology Research Center, national Institute of Aging, national Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland, U. S. A..; Source Info: Jun1981, Vol. 9 Issue 3, p128; Subject Term: DENTAL care; Subject Term: GUM disease; Subject Term: PERIODONTAL disease; Subject Term: PERIODONTICS; Subject Term: AGING; Subject Term: TEETH -- Care & hygiene; Author-Supplied Keyword: aging; Author-Supplied Keyword: dental care; Author-Supplied Keyword: dental status; Author-Supplied Keyword: gingival disease; Author-Supplied Keyword: oral physiology; Author-Supplied Keyword: periodontal disease.; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1600-0528.ep12096155
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tweed, Dan L.
AU  - Jackson, David J.
T1  - Psychiatric Disorder and Gender: A Logit Analysis.
JO  - Social Forces
JF  - Social Forces
Y1  - 1981/06//
VL  - 59
IS  - 4
M3  - Article
SP  - 1200
EP  - 1216
PB  - Oxford University Press / USA
SN  - 00377732
N1  - Accession Number: 5293490; Tweed, Dan L. 1 Jackson, David J. 2; Affiliation:  1: University of Maryland.  2: Mental Health Study Center, National Institute of Mental Health.; Source Info: Jun81, Vol. 59 Issue 4, p1200; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06549-002
AN  - 2006-06549-002
AU  - Zahn, Theodore P.
T1  - Environmental and Life Stress.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1981/06//
VL  - 26
IS  - 6
SP  - 423
EP  - 424
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06549-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety; Coping Behavior; Environmental Stress; Life Experiences. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Sarason, Irwin G. (Ed); Spielberger, Charles D. (Ed). Stress and Anxiety, Vol. 6: The Series in Clinical and Community Psychology=Washington, D.C.: Hemisphere, 1979 399 pp $22 00; 1979. Page Count: 2. Issue Publication Date: Jun, 1981. 
AB  - Reviews the book, Stress and Anxiety, Vol. 6: The Series in Clinical and Community Psychology edited by Irwin G. Sarason and Charles D. Spielberger (1979). The present volume has two rather definite focuses: environmental stress and life-event stress. The papers, with one exception, grew out of an Advanced Study Institute-held in Cambridge, England, in 1978 and sponsored by NATO-and represent contributions from Western Europe, Britain, Canada, and the United States. Most of them, like the NATO budget, come from the lastnamed country. An excellent chapter in this section by Stokols comes the closest of any to presenting a theoretical treatment of stress that would encompass both environmental and life stress. Stokols defines stress as 'a state of imbalance within an organism that is elicited by an actual or perceived disparity between environmental demands and the organism's capacity to cope with these demands. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - life-event stress
KW  - environmental stress
KW  - anxiety
KW  - 1981
KW  - Anxiety
KW  - Coping Behavior
KW  - Environmental Stress
KW  - Life Experiences
KW  - 1981
U2  - Sarason, Irwin G. (Ed); Spielberger, Charles D. (Ed). (1979); Stress and Anxiety, Vol. 6: The Series in Clinical and Community Psychology; Washington, D.C.: Hemisphere, 1979 399 pp $22 00
DO  - 10.1037/020244
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - O'BRIEN, STEPHEN J.
T1  - Owl Monkey Cell Line.
JO  - Science
JF  - Science
Y1  - 1981/06/12/
VL  - 212
IS  - 4500
M3  - Article
SP  - 1214
EP  - 1214
SN  - 00368075
N1  - Accession Number: 88003486; O'BRIEN, STEPHEN J. 1; Affiliations: 1: Genetics Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 6/12/1981, Vol. 212 Issue 4500, p1214; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FEDER, RALPH
AU  - COSTA, JONATHAN L.
AU  - CHAUDHARI, PRAVEEN
AU  - SAYRE, DAVID
T1  - Improved Detail in Biological Soft X-ray Microscopy: Study of Blood Platelets.
JO  - Science
JF  - Science
Y1  - 1981/06/19/
VL  - 212
IS  - 4501
M3  - Article
SP  - 1398
EP  - 1400
SN  - 00368075
AB  - Improved image quality in soft x-ray contact microscopy can be obtained by examining the resist with transmission rather than scanning electron microscopy. Application of the new technique to air-dried preparations of human blood platelets reveals structures not visible in the satne cells with transmission electron microscopy or when the resist is examined by scanning electron microscopy. As seen by the new technique, platelet pseudopods contain a central structure connected to a network in the platelet and dense bodies exhibit a lamellar structure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84714164; FEDER, RALPH 1; COSTA, JONATHAN L. 2; CHAUDHARI, PRAVEEN 3; SAYRE, DAVID 3; Affiliations: 1: IBM Watson Research Center, Yorktown Heights, New York, 10598; 2: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, 20205; 3: IBM, Watson Research Center; Issue Info: 6/19/1981, Vol. 212 Issue 4501, p1398; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BARRETT, J. CARL
AU  - WONG, ANNETTE
AU  - MCLACHLAN, JOHN A.
T1  - Diethylstilbestrol Induces Neoplastic Transformation Without Measurable Gene Mutation at Two Loci.
JO  - Science
JF  - Science
Y1  - 1981/06/19/
VL  - 212
IS  - 4501
M3  - Article
SP  - 1402
EP  - 1404
SN  - 00368075
AB  - The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84714166; BARRETT, J. CARL 1; WONG, ANNETTE 2; MCLACHLAN, JOHN A. 2; Affiliations: 1: Environmental Carcinogenesis Group, Laboratory of Pulmonary Function and Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709; 2: Transplacental Toxicology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences; Issue Info: 6/19/1981, Vol. 212 Issue 4501, p1402; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Moment, Gairdner B.
T1  - "CLINICAL" GERONTOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1981/07//Jul/Aug1981
VL  - 31
IS  - 7
M3  - Book Review
SP  - 540
EP  - 540
SN  - 00063568
AB  - The article reviews the book "Aging--Its Chemistry: Proceedings of the Third Arnold O. Beckman Conference in Clinical Chemistry," edited by Albert A. Dietz.
KW  - Aging
KW  - Nonfiction
KW  - Dietz, Albert A.
KW  - Aging: Its Chemistry: Proceedings of the Third Arnold O. Beckman Conference in Clinical Chemistry (Book)
N1  - Accession Number: 28051228; Moment, Gairdner B. 1; Affiliations: 1 : Gerontology Research Center, National Institute on Aging Baltimore, MD 21224;  Source Info: Jul/Aug1981, Vol. 31 Issue 7, p540; Subject Term: Aging; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 596
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - GEN
AU  - Chang, Ernest
AU  - Ricart, Glenn
AU  - Agrawala, Ashok K.
T1  - technical correspondence.
JO  - Communications of the ACM
JF  - Communications of the ACM
Y1  - 1981/07//
VL  - 24
IS  - 7
M3  - Letter
SP  - 468
EP  - 469
SN  - 00010782
AB  - A letter to the editor in response to the article "An Optimal Algorithm for Mutual Exclusion in Computer Networks," by G. Ricart and A. K. Agrawala in the January 181 issue is presented.
KW  - LETTERS to the editor
KW  - COMPUTER networks
N1  - Accession Number: 17854151; Chang, Ernest 1 Ricart, Glenn 2 Agrawala, Ashok K. 3; Affiliation:  1: University of Victoria, Victoria, B.C., Canada V8W 2Y2  2: National Institutes of Health, Bethesda, MD 20205  3: University of Maryland, College Park, MD 20742; Source Info: Jul1981, Vol. 24 Issue 7, p468; Subject Term: LETTERS to the editor; Subject Term: COMPUTER networks; NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-42918-004
AN  - 2013-42918-004
AU  - Shore, Milton F.
T1  - Marking time in the land of plenty: Reflections on mental health in the United States.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1981/07//
VL  - 51
IS  - 3
SP  - 391
EP  - 402
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Blvd. East, Adelphi, MD, US, 20783
N1  - Accession Number: 2013-42918-004. PMID: 7258305 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Centers; Government Policy Making; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 12. Issue Publication Date: Jul, 1981. Copyright Statement: American Orthopsychiatric Association, Inc. 1981. 
AB  - This article focuses on reflections on mental health in the United States. This accumulation of wisdom and knowledge from experts inside and outside government has for the most part been ignored or shelved over the years because of revisions, deferrals, impoundments, vetoes, threatened vetoes, reorganizations, budget cuts, inflation, and military demands. Programs such as Head Start, which have been proven successful, have been fighting for survival, and community mental health centers, which in many ways represented a bold, new approach with much creative promise, were threatened with the loss of federal funding in the early 1970s. The humanist tradition in mental health and social services is best exemplified by Pinel's unchaining of psychotic patients: Itards infinite patience in working with Victor, the wild child: and Jane Addams's extraordinary development of community programs. On an international level a recent report of the WHO European Regional Office also has called for a wide ranging, independent group that would cut across national governments and exercise influence at high political levels to insure that important mental health policies are implemented. Perhaps the day will even come when an American President will feel responsible and accountable to the nation in an annual report to Congress and the people on the progress made in health and social welfare areas in his or her administration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community programs
KW  - humanist tradition
KW  - mental health
KW  - mental health policies
KW  - 1981
KW  - Community Mental Health Centers
KW  - Government Policy Making
KW  - Mental Health
KW  - 1981
DO  - 10.1111/j.1939-0025.1981.tb01388.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - WONG-STAAL, FLOSSIE
AU  - DALLA-FAVERA, RICCARDO
AU  - FRANCHINI, GENOVEFFA
AU  - GELMANN, EDWARD P.
AU  - GALLO, ROBERT C.
T1  - Three Distinct Genes in Human DNA Related to the Transforming Genes of Mammalian Sarcoma Retroviruses.
JO  - Science
JF  - Science
Y1  - 1981/07/10/
VL  - 213
IS  - 4504
M3  - Article
SP  - 226
EP  - 228
SN  - 00368075
AB  - Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain offeline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84691502; WONG-STAAL, FLOSSIE 1; DALLA-FAVERA, RICCARDO 1; FRANCHINI, GENOVEFFA 1; GELMANN, EDWARD P. 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/10/1981, Vol. 213 Issue 4504, p226; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
AU  - DA SILVA, PEDRO PINTO
AU  - KACHAR, BECHARA
AU  - TORRISI, MARIA ROSARIA
AU  - BROWN, CHARLES
AU  - PARKISON, CLIFFORD
T1  - Freeze-Fracture Cytochemistry: Replicas of Critical Point-Dried Cells and Tissues After Fracture-Label.
JO  - Science
JF  - Science
Y1  - 1981/07/10/
VL  - 213
IS  - 4504
M3  - Article
SP  - 230
EP  - 233
SN  - 00368075
AB  - Applications of the newfracture-labeling techniques for the observation of cytochemical labels on platinum-carbon replicas are described. Frozen cells, embedded in a cross-linked protein matrix, and frozen tissues are fractured with a scalpel under liquid nitrogen, thawed, labeled, dehydrated by the critical point drying method, and replicated. This method allows direct, high-resolution, twodimensional chemical and immunological characterization of the cellular membranes in situ, as well as detection of sites within cross-fractured cytoplasm and extracellular matrix. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84691504; DA SILVA, PEDRO PINTO 1; KACHAR, BECHARA 1; TORRISI, MARIA ROSARIA 1; BROWN, CHARLES 1; PARKISON, CLIFFORD 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/10/1981, Vol. 213 Issue 4504, p230; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FRIEDMAN, ROBERT M.
T1  - Interferon and Interferon Inducers.
JO  - Science
JF  - Science
Y1  - 1981/07/17/
VL  - 213
IS  - 4505
M3  - Book Review
SP  - 326
EP  - 327
SN  - 00368075
AB  - A review of the book "Interferon and Interferon Inducers: Clinical Applications," by Dale A. Stringfellow is presented.
KW  - Interferons
KW  - Nonfiction
KW  - Stringfellow, Dale A.
KW  - Interferon & Interferon Inducers: Clinical Applications (Book)
N1  - Accession Number: 84691538; FRIEDMAN, ROBERT M. 1; Affiliations: 1: Laboratory of Experimental Pathology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/17/1981, Vol. 213 Issue 4505, p326; Subject Term: Interferons; Subject Term: Nonfiction; Reviews & Products: Interferon & Interferon Inducers: Clinical Applications (Book); People: Stringfellow, Dale A.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MARSHALL, K. C.
AU  - PUN, R. Y. K.
AU  - HENDELMAN, W. J.
AU  - NELSON, P. G.
T1  - A Coeruleo-Spinal System in Culture.
JO  - Science
JF  - Science
Y1  - 1981/07/17/
VL  - 213
IS  - 4505
M3  - Article
SP  - 355
EP  - 357
SN  - 00368075
AB  - In combined cultures of dissociated spinal neurons and explants from the region of locus coeruleus, rich catecholamine-containing fiber projections from the explant to the surrounding regions of spinal neurons were demonstrated by fluorescence histochemistry. Electrical stimulation of the explant resulted in slow depolarizing responses in many of the spinal neurons. Cells exhibiting this type of response were also usually depolarized by local application of noradrenaline, whereas other, unresponsive neurons usually were not. The depolarizing responses to electrical stimulation and to noradrenaline were both increased by depolarizing current injection and decreased by hyperpolarizing current. These and other data suggest that the depolarizing responses of the spinal neurons to explant stimulation are mediated by noradrenaline released from axons of locus coeruleus neurons. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Locus coeruleus
KW  - Neurons -- Development
KW  - Noradrenaline
KW  - Catecholamines
KW  - Neuromuscular depolarizing agents
KW  - Axons
N1  - Accession Number: 84691555; MARSHALL, K. C. 1; PUN, R. Y. K. 2; HENDELMAN, W. J. 3; NELSON, P. G. 4; Affiliations: 1: Department of Physiology, University of Ottawa, Ottawa, Ontario, Canada KIN 9A9; 2: Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Anatomy, University of Ottawa; 4: Laboratory of Developmental Neurobiology, National Institutes of Health; Issue Info: 7/17/1981, Vol. 213 Issue 4505, p355; Thesaurus Term: RESEARCH; Subject Term: Locus coeruleus; Subject Term: Neurons -- Development; Subject Term: Noradrenaline; Subject Term: Catecholamines; Subject Term: Neuromuscular depolarizing agents; Subject Term: Axons; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MURPHY, MICHAEL R.
AU  - MACLEAN, PAUL D.
AU  - HAMILTON, SUE C.
T1  - Species-Typical Behavior of Hamsters Deprived from Birth of the Neocortex.
JO  - Science
JF  - Science
Y1  - 1981/07/24/
VL  - 213
IS  - 4506
M3  - Article
SP  - 459
EP  - 461
SN  - 00368075
AB  - Hamsters deprivedfrom birth of the neocortex developed normally and displayed the usual hamster-typical behavioral patterns. With the additional concurrent destruction of midline limbic convolutions (cingullate and underlying dorsal hippocampal), there were deficits in maternal behavior and a lack of development of play behavior. These findings demonstrate in a rodent (i) that the striatal complex and limbic system, along with the remaining neuraxis, are sufficient for giving expression to a wide range of unlearned forms of species-typical behavior and (ii) that midline limbic structures are required for the expression oj play behavior and the integrated performance of maternal behavior. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84691600; MURPHY, MICHAEL R. 1; MACLEAN, PAUL D. 1; HAMILTON, SUE C. 1; Affiliations: 1: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health, Post Office Box 289, Poolesville, Maryland 20837; Issue Info: 7/24/1981, Vol. 213 Issue 4506, p459; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HOFFER, J. A.
AU  - O'DONOVAN, M. J.
AU  - PRATT, C. A.
AU  - LOEB, G. E.
T1  - Discharge Patterns of Hindlimb Motoneurons During Normal Cat Locomotion.
JO  - Science
JF  - Science
Y1  - 1981/07/24/
VL  - 213
IS  - 4506
M3  - Article
SP  - 466
EP  - 468
SN  - 00368075
AB  - Long-term recording from single lumbar motoneurons of intact cats revealed activation patterns fundamentally differentfrom those seen in decerebrate preparations. In intact cats, motoneuron bursts showed marked rate modulation without initial doublets. Each unit's frequencygram generally resembled the envelope of the gross electromyogram simultaneously recorded from the corresponding muscle. Average and peak discharge rates increasedforfaster gaits. These findings suggest that, in cat locomotion, rate modulation is a more important contributor to force regulation than was previously thought. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84691604; HOFFER, J. A. 1; O'DONOVAN, M. J. 1; PRATT, C. A. 1; LOEB, G. E. 1; Affiliations: 1: Laboratory of Neural Control, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/24/1981, Vol. 213 Issue 4506, p466; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KACHAR, BECHARA
AU  - DA SILVA, PEDRO PINTO
T1  - Rapid Massive Assembly of Tight Junction Strands.
JO  - Science
JF  - Science
Y1  - 1981/07/31/
VL  - 213
IS  - 4507
M3  - Article
SP  - 541
EP  - 544
SN  - 00368075
AB  - Incubation at 37°C of excised rat prostate tissue results in massive proliferative assembly of new tight junction strands along the entire length of the lateral plasma membranes of the columnar epithelial cells. The new tight junction elements are assembled within 5 minutes and have an average length six times that of those present in the apical tight junction band. Massive assembly occurs in the presence of protein synthesis inhibitors (cycloheximide) or of metabolic uncouplers (dinitrophenol). Thus, proliferative assembly of tight junction strands involves molecular reorganization from a pool of preexisting, probably membrane-associated, components. The fascia occludens and some examples of experimentally induced tight junction proliferation may reflect the massive emergence of tight junction strands when tissue is subjected to diverse stressful conditions. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85464218; KACHAR, BECHARA 1; DA SILVA, PEDRO PINTO 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p541; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - UDEINYA, IROKA J.
AU  - SCHMIDT, JOHN A.
AU  - AIKAWA, MASAMICHI
AU  - MILLER, LOUIS H.
AU  - GREEN, IRA
T1  - Falciparum Malaria-Infected Erythrocytes Specifically Bind to Cultured Human Endothelial Cells.
JO  - Science
JF  - Science
Y1  - 1981/07/31/
VL  - 213
IS  - 4507
M3  - Article
SP  - 555
EP  - 557
SN  - 00368075
AB  - Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to culturedfibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, or components, in the knobs of the infected erythrocytes. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85464224; UDEINYA, IROKA J. 1; SCHMIDT, JOHN A. 2; AIKAWA, MASAMICHI 3; MILLER, LOUIS H. 4; GREEN, IRA 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases; 3: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 64108; 4: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p555; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - YONEDA, TOSHIYUKI
AU  - PRATT, ROBERT M.
T1  - Mesenchymal Cells from the Human Embryonic Palate Are Highly Responsive to Epidermal Growth Factor.
JO  - Science
JF  - Science
Y1  - 1981/07/31/
VL  - 213
IS  - 4507
M3  - Article
SP  - 563
EP  - 565
SN  - 00368075
AB  - An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85464228; YONEDA, TOSHIYUKI 1; PRATT, ROBERT M. 1; Affiliations: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p563; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NAMBOODIRI, M. A. A.
AU  - FAVILLA, J. T.
AU  - KLEIN, D. C.
T1  - Pineal N-Acetyltransferase Is Inactivated by Disulfide-Containing Peptides: Insulin Is the Most Potent.
JO  - Science
JF  - Science
Y1  - 1981/07/31/
VL  - 213
IS  - 4507
M3  - Article
SP  - 571
EP  - 573
SN  - 00368075
AB  - Pineal N-acetyltransferase can be inactivated in broken cell preparations by cystamine through a mechanism of thiol-disulfide exchange. Some, but not all, disulfide-containing peptides can inactivate this enzyme; the most potent inactivator is insulin. These findings suggest that a disulfide-containing peptide with high reactivity toward N-acetyltransferase may participate in the intracellular regulation of this enzyme. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85464232; NAMBOODIRI, M. A. A. 1; FAVILLA, J. T. 1; KLEIN, D. C. 1; Affiliations: 1: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p571; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HAll, R.P.
AU  - Strober, W.
AU  - Katz, S.I.
AU  - Lawley, T.J.
T1  - IgA-containing circulating immune complexes in gluten-sensitive enteropathy.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/08//
VL  - 45
IS  - 2
M3  - Article
SP  - 234
EP  - 239
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Since mucosal immune response involving IgA may be particularly important in the pathogenesis of gluten-sensitive enteropathy (GSE). We examined the sera of 22 patients with GSE for IgA-containing circulating immune complexes using a sensitive radioimmunoassay. The Raji cell assay for IgA-containing circulating immune complexes. The Raji cell assay for lgG-containing circulating immune complexes and the 125-Clq-binding assay were also used to measure IgG- or IgM-containing circulating immune complexes in these patients. Ten of 22 (45%) patients had IgA-containing circulating immune complexes, while II of 22 (50%) had lgG- or IgM-containing circulating immune complexes. Thirteen of 22 (59%) patients had circulating immune complexes detected by at least one of the assays used. Neither the presence nor level of immune complexes correlated with disease activity in any of the patients studied. Five patients, whose disease was well controlled on a gluten-free diet, were studied serially during dietary challenge with gluten. It was found that IgA-containing circulating immune complexes did not develop or increase in amount in the serum of these patients despite the induction of gastrointestinal symptoms. In addition, no significant change in lgG- or IgM- containing circulating immune complexes occurred in any of the challenged patients. No significant abnormalities of serum complement levels (C3, C4, factor B) were detected in any of the patients including those challenged with gluten. Sucrose density-gradient ultracentrifugation studies revealed that the IgA-containing circulating immune complexes had sedimentation characteristics between 9S and 13S. The presence of circulating immune complexes in only 59%, of patients with GSE, their lack of correlation with disease activity, and their failure to change during dietary gluten challenge suggests that circulating immune complexes do not play a primary role in the pathogenesis of GSE. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNOGLOBULINS
KW  - PLANT proteins
KW  - DIET in disease
KW  - BLOOD plasma
KW  - DIET therapy
KW  - GLUTEN-free diet
N1  - Accession Number: 15961755; HAll, R.P. 1 Strober, W. 2 Katz, S.I. 1 Lawley, T.J. 1; Affiliation:  1: Dermatology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.  2: Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Aug1981, Vol. 45 Issue 2, p234; Subject Term: IMMUNOGLOBULINS; Subject Term: PLANT proteins; Subject Term: DIET in disease; Subject Term: BLOOD plasma; Subject Term: DIET therapy; Subject Term: GLUTEN-free diet; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hook, W. A.
AU  - Siraganian, R. P.
T1  - Influence of anions, cations and osmolarity on IgE-mediated histamine release from human basophils.
JO  - Immunology
JF  - Immunology
Y1  - 1981/08//
VL  - 43
IS  - 4
M3  - Article
SP  - 723
EP  - 731
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Allergen-activated human basophils require Ca2+ for the in vitro release of histamine. This study evaluated the importance of anions, cations and osmotic pressure on histamine release from human basophils. All media contained 1 mM Ca2+ and various salts or sugars were used to replace the NaCl-KCl of the control medium. Permeant anions supported release of histamine with the following order of activities:acetate->Br-,I-, >Cl-≫SO42-. When monovalent cations of the standard medium were replaced, RbCI, CsCI, KCl or NaCl gave results identical to the NaCl-KCl control medium; choline chloride usually enhanced while LiCI inhibited release. Finally, when sugar solutions were used to replace monovalent anions and cations of the standard medium: mannitol, lactose, sucrose, sorbitol, fructose and glucose each supported histamine release. Increasing the osmolarity of the medium by adding additional NaCl-KCl enhanced the ability of suboptimal concentrations of ragweed antigen E or anti-IgE to activate and to release histamine from leucocytes. The results indicate that histamine release from basophils requires only Ca2+ and do not support the 'chemiosmotic swelling' hypothesis of secretion for these cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANIONS
KW  - CATIONS
KW  - IMMUNOGLOBULIN E
KW  - HISTAMINE
KW  - BASOPHILS
KW  - CARBOHYDRATES
N1  - Accession Number: 13989833; Hook, W. A. 1 Siraganian, R. P. 1; Affiliation:  1: Clinical Immunology Section, Laboratory of Microbiology and Immunology, National institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug81, Vol. 43 Issue 4, p723; Subject Term: ANIONS; Subject Term: CATIONS; Subject Term: IMMUNOGLOBULIN E; Subject Term: HISTAMINE; Subject Term: BASOPHILS; Subject Term: CARBOHYDRATES; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tamaki, Kunihiko
AU  - Fujiwara, Hiromi
AU  - Levy, Robert B.
AU  - Shearer, Gene M.
AU  - Katz, Stephen I.
T1  - Hapten Specific TNP-reactive Cytotoxic Effector Cells Using Epidermal Cells as Targets.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/08//
VL  - 77
IS  - 2
M3  - Article
SP  - 225
EP  - 229
SN  - 0022202X
AB  - Epidermal spongiosis, invasion of mononuclear cells into the epidermis, and epidermal cell destruction are regular findings in allergic contact dermatitis. The mechanism(s) by which these changes occur is not known. We have examined the possibility that some of the pathological changes observed in allergic contact dermatitis could be accounted for by invasion of the epidermis by cytotoxic effector cells which recognize hapten-modified self-antigens and therein cause epidermal cell destruction. C3H and BALB/c mice were sensitized by epicutaneously applied 7% trinitrochlorobenzene (TNCB). 14 days later spleen cells from these mice were stimulated <em>in vitro</em> to trinitrophenylated-(TNP-conjugated) syngeneic spleen cells and their responses were compared to the <em>in vitro</em> responses of spleen cells from unsensitized mice. After 5 days of culture, effector cell activity was assayed on 51Cr-labeled TNP-conjugated syngeneic epidermal cells and on unconjugated epidermal cells. Cytotoxic activity was detected in the spleens of both mouse strains, but was greater in the C3H than the BALB/c strain. The cytotoxic effector cell activity was hapten specific in that spleen cells from TNCB sensitized mice did not cause lysis of fluorescein isothiocyanate (FITC) conjugated epidermal cells and spleen cells from FITC sensitized mice did not cause lysis of TNP-conjugated epidermal cells. No significant cytotoxic activity was detected on unconjugated epidermal cells. These findings suggest that destruction of the epidermis in allergic contact dermatitis may be contributed to by sensitized cytotoxic effector cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN -- Inflammation
KW  - LYMPHOID tissue
KW  - EPITHELIUM
KW  - CELL-mediated cytotoxicity
KW  - PATHOLOGY
KW  - CHLOROBENZENE
N1  - Accession Number: 12480043; Tamaki, Kunihiko 1 Fujiwara, Hiromi 1 Levy, Robert B. 1 Shearer, Gene M. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology and Immunology Branches, National Cancer Institute, NIH, Bethesda, Maryland, U.S.A.; Source Info: Aug81, Vol. 77 Issue 2, p225; Subject Term: SKIN -- Inflammation; Subject Term: LYMPHOID tissue; Subject Term: EPITHELIUM; Subject Term: CELL-mediated cytotoxicity; Subject Term: PATHOLOGY; Subject Term: CHLOROBENZENE; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12480043
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kraemer, Kenneth H.
AU  - Levis, William R.
AU  - Cason, Joseph C.
AU  - Tarone, Robert E.
T1  - Inhibition of Mixed Leukocyte Culture Reaction by 8-Methoxypsoralen and Long-wavelength Ultraviolet Radiation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/08//
VL  - 77
IS  - 2
M3  - Article
SP  - 235
EP  - 239
SN  - 0022202X
AB  - Psoriasis patients receiving therapy with oral 8-methoxypsoralen plus long-wavelength ultraviolet radiation have been reported to have diminished leukocyte DNA synthesis and immune reactivity. In order to quantitate the immunological effects of therapeutic concentrations of 8-methoxypsoralen plus long-wavelength ultraviolet radiation, we measured the mixed leukocyte culture reaction <em>in vitro</em>. Leukocytes treated with 8-methoxypsoralen were exposed to plate glass filtered ultraviolet radiation from a bank of "PUVA" fluorescent lamps. To evaluate the (two-way) mixed leukocyte reaction, treated leukocytes were mixed with untreated leukocytes from another donor in microtiter wells and tritiated thymidine incorporation was measured after 4 to 6 days. To measure stimulation or proliferation ability (one-way mixed leukocyte reactions), treated or untreated leukocytes were exposed to 2000 R X-radiation prior to mixing. Treatment of leukocytes with 8-methoxypsoralen (0.01, 0.1, or 1.0 μg/ml) followed by 7,000 to 87,000 J/m² long-wavelength ultraviolet radiation resulted in a dose dependent inhibition of mixed leukocyte culture reactivity. 0.1 μg/ml 8-methoxypsoralen plus 7,000 J/m² ultraviolet radiation resulted in a 48% reduction (p < 0.01) in mixed leukocyte reaction-induced tritiated thymidine incorporation in the two-way assay. 1 μg/ml 8-methoxypsoralen plus 87,000 J/m² ultraviolet radiation virtually abolished reactivity in the two-way mixed leukocyte reaction and in both one-way mixed leukocyte reactions. Exposure to 87,000 J/m² long wavelength ultraviolet radiation alone resulted in 45% inhibition (p < 0.01) of stimulation ability. These results indicate that therapeutic concentrations of 8-methoxypsoralen followed by exposure to long-wavelength ultraviolet radiation inhibited both the stimulating ability and the mixed leukocyte culture reaction-induced proliferation of peripheral blood leukocytes <em>in vitro</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRAVIOLET radiation
KW  - PYRIMIDINE nucleotides
KW  - SKIN diseases
KW  - DNA synthesis
KW  - THYMIDINE
KW  - LEUCOCYTES
N1  - Accession Number: 12480072; Kraemer, Kenneth H. 1 Levis, William R. 2 Cason, Joseph C. 2 Tarone, Robert E. 3; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  3: Biometry Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug81, Vol. 77 Issue 2, p235; Subject Term: ULTRAVIOLET radiation; Subject Term: PYRIMIDINE nucleotides; Subject Term: SKIN diseases; Subject Term: DNA synthesis; Subject Term: THYMIDINE; Subject Term: LEUCOCYTES; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12480072
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Alvarez, Oscar M.
AU  - Bere Jr., E. William
AU  - Eaglstein, William H.
AU  - Katz, Stephen I.
T1  - Detection of Basement Membrane Zone Antigens During Epidermal Wound Healing in Pigs.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1981/08//
VL  - 77
IS  - 2
M3  - Article
SP  - 240
EP  - 243
SN  - 0022202X
AB  - Bullous pemphigoid (BP) antigen, laminin, and type IV collagen, 3 distinct antigens of basement membrane, were studied by indirect immunofluorescence in the epidermal-dermal junction of re-epithelializing wounds. Partial thickness wounds were made with a dermatome in the skin of white Yorkshire pigs. After 2 or 3 days, the wound site and the surrounding normal skin were excised and cryostat sections were studied using BP sera as well as whole antisera and affinity purified antibodies to laminin and type IV collagen. Laminin and type IV collagen were detected in the basement membrane zone of normal epidermis and at the re-epithelializing epidermal-dermal junction for a variable distance into the healing wound but both were absent from the more distal migrating epidermis. In contrast, BP antigen extended from the basement membrane zone of normal skin throughout the entire epidermal-dermal junction of the wound as far as the distal tip of the migrating epidermis. These results suggest that in the re-epithelization of superficial wounds laminin and type IV collagen are not present in the initial epidermal-dermal interaction of the migrating epithelium but that BP antigen may be important in this early interaction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPITHELIUM
KW  - IMMUNOGLOBULINS
KW  - COLLAGEN
KW  - WOUND healing
KW  - IMMUNOFLUORESCENCE
KW  - IMMUNITY
N1  - Accession Number: 12480082; Stanley, John R. 1,2 Alvarez, Oscar M. 3 Bere Jr., E. William 1 Eaglstein, William H. 3 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch of the National Cancer Institute, National of Health, Bethesda, Maryland.  2: Laboratory of Development Biology and Anomalies of the National Institute of Dental Research National of Health, Bethesda, Maryland.  3: Department of Dermatology, University of Miami, Miami, Florida, U.S.A.; Source Info: Aug81, Vol. 77 Issue 2, p240; Subject Term: EPITHELIUM; Subject Term: IMMUNOGLOBULINS; Subject Term: COLLAGEN; Subject Term: WOUND healing; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNITY; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12480082
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Epstein, David A.
AU  - Czarniecki, Christine W.
AU  - Jacobsen, Helmut
AU  - Friedman, Robert M.
AU  - Panet, Amos
T1  - A Mouse Cell Line which Is Unprotected by Interferon against Lytic Virus Infection, Lacks Ribonuclease F Activity.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/08/03/
VL  - 118
IS  - 1
M3  - Article
SP  - 9
EP  - 15
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Analyzes enzymatic pathways which are induced by interferon in a mouse cell line.  Inhibition of Moloney murine leukemia virus production; Phosphorylation; Level of the oligoadenylate synthetase activity; Induction of protein kinase activity.
KW  - ENZYMES
KW  - INTERFERONS
KW  - CELL lines
KW  - MICE as laboratory animals
KW  - MOUSE leukemia viruses
KW  - PHOSPHORYLATION
N1  - Accession Number: 12269915; Epstein, David A. 1 Czarniecki, Christine W. 1 Jacobsen, Helmut 1 Friedman, Robert M. 1 Panet, Amos 1; Affiliation:  1: Laboratory of Experimental Pathology, National Institutes of Health, National Institute of Arthritis, Metabolic, Digestive Diseases, Bethesda, and The Department of Virology, The Hebrew University, Hadassah Medical School, Jerusalem; Source Info: 8/3/81, Vol. 118 Issue 1, p9; Subject Term: ENZYMES; Subject Term: INTERFERONS; Subject Term: CELL lines; Subject Term: MICE as laboratory animals; Subject Term: MOUSE leukemia viruses; Subject Term: PHOSPHORYLATION; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HARPER, R. M.
AU  - LEAKE, B.
AU  - HOFFMAN, H.
AU  - WALTER, D. 0.
AU  - HOPPENBROUWERS, T.
AU  - HODGMAN, J.
AU  - STERMAN, M. B.
T1  - Periodicity of Sleep States Is Altered in Infants at Risk for the Sudden Infant Death Syndrome.
JO  - Science
JF  - Science
Y1  - 1981/08/28/
VL  - 213
IS  - 4511
M3  - Article
SP  - 1030
EP  - 1032
SN  - 00368075
AB  - The normal succession of sleep and waking states through a night is disturbed in infants at risk for the sudden infant death syndrome. Compared with normal infants, siblings of the sudden infant death syndrome victims have longer intervals between active sleep epochs at particular times during the night in the newborn period and a decreased tendency to enter short waking periods at 2 and 3 months of age. The latterfinding is interpreted as an increased tendency to remain asleep, or a relative failure to arouse from sleep in infants at risk. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84691786; HARPER, R. M. 1; LEAKE, B. 1; HOFFMAN, H. 2; WALTER, D. 0. 3; HOPPENBROUWERS, T. 4; HODGMAN, J. 4; STERMAN, M. B. 5; Affiliations: 1: Department of Anatomy and Brain Research Institute, University of California, Los Angeles 90024; 2: Biometry Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 3: Brain Research Institute, University of California; 4: Department of Pediatrics and Newborn Service, Los Angeles County- University of Southern California Medical Center, Los Angeles 90033; 5: Veterans Administration Medical Center, Sepulveda, California 91343; Issue Info: 8/28/1981, Vol. 213 Issue 4511, p1030; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Bowery, Thomas G.
T1  - RISK MONEY FOR RESEARCH.
JO  - BioScience
JF  - BioScience
Y1  - 1981/09//
VL  - 31
IS  - 8
M3  - Letter
SP  - 556
EP  - 557
SN  - 00063568
AB  - A letter to the editor is presented in response to the article "Opinion," by Gairdner B. Moment in the June 1981 issue.
KW  - Letters to the editor
KW  - Research grants
N1  - Accession Number: 28051236; Bowery, Thomas G. 1; Affiliations: 1 : Biomedical Research Support Program Division of Research Resources National Institutes of Health Bethesda, MD 20205;  Source Info: Sep1981, Vol. 31 Issue 8, p556; Subject Term: Letters to the editor; Subject Term: Research grants; Number of Pages: 2p; Document Type: Letter; Full Text Word Count: 581
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Nagel, James E.
T1  - CELLULAR IMMUNOBIOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1981/09//
VL  - 31
IS  - 8
M3  - Book Review
SP  - 610
EP  - 610
SN  - 00063568
AB  - The article reviews the book "Regulatory T Lymphocytes," edited by Benvenuto Pernis and Henry J. Vogel.
KW  - Lymphocytes
KW  - Nonfiction
KW  - Pernis, Benvenuto
KW  - Vogel, Henry J.
KW  - Regulatory T Lymphocytes (Book)
N1  - Accession Number: 28051259; Nagel, James E. 1; Affiliations: 1 : National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, MD 21224;  Source Info: Sep1981, Vol. 31 Issue 8, p610; Subject Term: Lymphocytes; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 470
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Glynn, Thomas J.
T1  - Psychological Sense of Community: Measurement and Application.
JO  - Human Relations
JF  - Human Relations
Y1  - 1981/09//
VL  - 34
IS  - 9
M3  - Article
SP  - 789
SN  - 00187267
AB  - The development and testing of an Instrument designed to measure "psychological sense of community" (PSC) is described. A discussion of the historical background of the PSC concept is presented and results of the use of the instrument in three U. S. and Israeli communities are described. Specific attention is given to the relationship of PSC and the variables of community satisfaction and competence as well as to applications of the PSC instrument. Since results suggest that certain manipulable variables may be associated with PSC, and that PSC itself may have the properties of a construct, suggestions for further research, and the potential importance of PSC for community development and maintenance are given. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human Relations is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMMUNITY development
KW  - SOCIAL planning
KW  - SOCIAL sciences
KW  - COMMUNITIES -- Psychological aspects
KW  - ISRAEL
KW  - UNITED States
N1  - Accession Number: 4978407; Glynn, Thomas J. 1; Affiliations: 1: National Institute on Drug Abuse, 5600 Fishers Lane, Rockville, Maryland 20857.; Issue Info: Sep81, Vol. 34 Issue 9, p789; Thesaurus Term: COMMUNITY development; Subject Term: SOCIAL planning; Subject Term: SOCIAL sciences; Subject Term: COMMUNITIES -- Psychological aspects; Subject: ISRAEL; Subject: UNITED States; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 30p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 
TY  - JOUR
AU  - Macdermott, R. P.
AU  - Kienker, Laura J.
AU  - Vertovich, M. J.
AU  - Muchmore, A. V.
T1  - Inhibition of spontaneous but not antibody-dependent cell-mediated cytotoxicity by simple sugars: evidence that endogenous lectins may mediate spontaneous cell-mediated cytotoxicity.
JO  - Immunology
JF  - Immunology
Y1  - 1981/09//
VL  - 44
IS  - 1
M3  - Article
SP  - 143
EP  - 152
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Using Chang and K-562 cell line cells as targets, we have observed that a number of sugars are capable of inhibiting spontaneous cell-mediated cytotoxicity (SCMC) but not antibody-dependent cell-mediated cytotoxicity (ADCC). The sugars D(-)ribose, β-gentiobiose, N-acetyl-D-galatosamine, and α-lactose all significantly inhibited SCMC of Chang and K-562 cell line cells. Because these same sugars caused no inhibition of ADCC against either Chang or K-562 cell line cells in assays run simultaneously, the results do not appear to be due to a non-specific toxic effect of the sugars against the effector cells. These studies add to the evidence that ADCC and SCMC are mediated by separate receptors. Furthermore, they provide evidence that endogenous lectin receptors or lectin-like molecules may be involved in the recognition and/or effector stages leading to SCMC. Thus, NK cells may recognize targets by virtue of receptors capable of interacting with monosaccharide, disaccharide, or oligosaccharide sequences present alone, as glycolipids, and/or as glycoproteins on the target cell surface. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIBODY-dependent cell cytotoxicity
KW  - CELL-mediated cytotoxicity
KW  - CELL lines
KW  - CELL culture
KW  - CELLULAR immunity
N1  - Accession Number: 13958923; Macdermott, R. P. 1 Kienker, Laura J. 1 Vertovich, M. J. 1 Muchmore, A. V. 1; Affiliation:  1: Hughes Medical Research Institute and Division of Gastroenterology, Washington University Medical Center, St. Louis, Missouri and Cellular Immunology Section, Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep81, Vol. 44 Issue 1, p143; Subject Term: ANTIBODY-dependent cell cytotoxicity; Subject Term: CELL-mediated cytotoxicity; Subject Term: CELL lines; Subject Term: CELL culture; Subject Term: CELLULAR immunity; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Smith, Paul J.
AU  - Rae, Donald S.
AU  - Manderscheid, Ronald W.
AU  - Silbergeld, Sam
T1  - Approximating the Moments and Distribution of the Likelihood Ratio Statistic for Multinomial Goodness of Fit.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1981/09//
VL  - 76
IS  - 375
M3  - Article
SP  - 737
SN  - 01621459
AB  - Approximations were derived for the mean and variance of G[sup 2], the likelihood ratio statistic for testing goodness of fit in a k cell multinomial distribution. These approximate moments, accurate to O(N[sup -3]), may be used in fitting the distribution of G[sup 2]. Extensive numerical studies of the exact and approximate distributions were performed in the special case of equiprobability. The asymptotic chi-squared distribution was found to fit poorly for k >/= 4. Satisfactory results were obtained using a multiplicative correction to the chi-squared fit. More sophisticated procedures using the beta distribution produced increased accuracy, but at the cost of excessive computational labor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APPROXIMATION theory
KW  - ANALYSIS of variance
KW  - DISTRIBUTION (Probability theory)
KW  - STOCHASTIC convergence
KW  - MATHEMATICAL analysis
KW  - CHARACTERISTIC functions
KW  - ASYMPTOTIC expansions
KW  - GOODNESS-of-fit tests
KW  - NUMERICAL analysis
KW  - Asymptotic moment expansions
KW  - Beta distribution
KW  - Chi-squared distribution
KW  - Entropy statistic
KW  - Equiprobability
KW  - Information statistic.
N1  - Accession Number: 4607877; Smith, Paul J. 1; Rae, Donald S. 2; Manderscheid, Ronald W. 3; Silbergeld, Sam 4; Affiliations: 1: Associate Professor, Department of Mathematics, University of Maryland, College Park, MD 20742.; 2: Mathematician, Division of Computer Systems, Alcohol, Drug Abuse, and Mental Health Administration, Rockville, MD 20857.; 3: Research Sociologist and Chief, Evaluation and Needs Assessment Section, Division of Biometry and Epidemiology, National Institute of Mental Health, Rockville, MD 20857; 4: Research Psychiatrist, Chief, Biopsychosocial Research Section, Mental Health Study Center, National Institute of Mental Health, Adeiphi, MD 20783.; Issue Info: Sep81, Vol. 76 Issue 375, p737; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: MATHEMATICAL analysis; Subject Term: CHARACTERISTIC functions; Subject Term: ASYMPTOTIC expansions; Subject Term: GOODNESS-of-fit tests; Subject Term: NUMERICAL analysis; Author-Supplied Keyword: Asymptotic moment expansions; Author-Supplied Keyword: Beta distribution; Author-Supplied Keyword: Chi-squared distribution; Author-Supplied Keyword: Entropy statistic; Author-Supplied Keyword: Equiprobability; Author-Supplied Keyword: Information statistic.; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Weinfeld, Morton
AU  - Sigal, John J.
AU  - Eaton, William W.
T1  - Long-Term Effects of the Holocaust on Selected Social Attitudes and Behaviors of Survivors: A Cautionary Note.
JO  - Social Forces
JF  - Social Forces
Y1  - 1981/09//
VL  - 60
IS  - 1
M3  - Article
SP  - 1
EP  - 19
SN  - 00377732
AB  - A random sample of Jewish survivors of the Holocaust in Montreal is compared with two Jewish control groups. Modest or insignificant differences were found on measures of perceived anti-Semitism, economic and political satisfaction, social segregation, economic achievement, and propensity to migrate from Quebec. The findings caution against overgeneralization of a clinical construct, the survivor syndrome, and point to the need for further research into the remarkable capacities of human beings to overcome the most severe forms of victimization. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOLOCAUST (1939-1945)
KW  - SOCIAL attitudes
KW  - HOLOCAUST survivors
KW  - ANTISEMITISM
KW  - JEWS
KW  - CONCENTRATION camps
KW  - BEHAVIOR
KW  - ATTITUDE (Psychology)
KW  - MONTREAL (Quebec)
KW  - QUEBEC (Province)
KW  - CANADA
N1  - Accession Number: 5287345; Weinfeld, Morton 1; Sigal, John J. 2; Eaton, William W. 3; Affiliations: 1 : McGill University.; 2 : Sir Mortimer B. Davis-Jewish General Hospital, Montreal.; 3 : National Institute of Mental Health.;  Source Info: Sep81, Vol. 60 Issue 1, p1; Historical Period: 1978; Subject Term: HOLOCAUST (1939-1945); Subject Term: SOCIAL attitudes; Subject Term: HOLOCAUST survivors; Subject Term: ANTISEMITISM; Subject Term: JEWS; Subject Term: CONCENTRATION camps; Subject Term: BEHAVIOR; Subject Term: ATTITUDE (Psychology); Subject: MONTREAL (Quebec); Subject: QUEBEC (Province); Subject: CANADA; Number of Pages: 19p; Illustrations: 7 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - KAPATOS, GREGORY
AU  - KAUFMAN, SEYMOUR
AU  - WELLER, JOAN L.
AU  - KLEIN, DAVID C.
T1  - Biosynthesis of Biopterin: Adrenergic Cyclic Adenosine Monophosphate-Dependent Inhibition in the Pineal Gland.
JO  - Science
JF  - Science
Y1  - 1981/09/04/
VL  - 213
IS  - 4512
M3  - Article
SP  - 1129
EP  - 1131
SN  - 00368075
AB  - Pineal glands in organ culture synthesize and release biopterin and are able to maintain concentrations of biopterin occurring in vivo for up to 54 hours in vitro. The intracellular biopterin content is reduced 50 percent by treatment with 1- norepinephrine or cyclic adenosine monophosphate derivatives, but not by dnorepinephrine. This is an indication that biopterin levels are regulated by an adrenergic cyclic adenosine monophosphate-dependent mechanism. The decline in tissue biopterin content, produced mainly by inhibition of biosynthesis, is maximal at 6 hours and is not associated with either an increase in biopterin release or a shift in the reduction state of the biopterin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84691831; KAPATOS, GREGORY 1; KAUFMAN, SEYMOUR 1; WELLER, JOAN L. 2; KLEIN, DAVID C. 2; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Neuroendocrinology Section, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 9/ 4/1981, Vol. 213 Issue 4512, p1129; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MONASTERIO, F. M. DE
AU  - SCHEIN, S. J.
AU  - MCCRANE, E. P.
T1  - Stainin of Blue-Sensitive Cones of the Macaque Retina by a Fluorescent Dye.
JO  - Science
JF  - Science
Y1  - 1981/09/11/
VL  - 213
IS  - 4513
M3  - Article
SP  - 1278
EP  - 1281
SN  - 00368075
AB  - Intravitreal injection of a fluorescent dye, Procion yellow, results in the complete and systematic staining of a cone population in the monkey retina. These cones form an approximately regular array whose separation varies with retinal eccentricity. They are absent in the very center of the fovea, and their density peaks at 1°. The distribution of stained cones resembles that reported for blue-sensitive cones of other primates and, consistent with such an identification, they are found with less incidence in species having lower concentrations of blue cones. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85483540; MONASTERIO, F. M. DE 1; SCHEIN, S. J. 1; MCCRANE, E. P. 1; Affiliations: 1: Section on Visual Processing, Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/11/1981, Vol. 213 Issue 4513, p1278; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TREISER, SUSAN L.
AU  - CASCIO, CAREN S.
AU  - O'DONOHUE, THOMAS L.
AU  - THOA, NGUYEN B.
AU  - JACOBOWITZ, DAVID M.
AU  - KELLAR, KENNETH J.
T1  - Lithium Increases Serotonin Release and Decreases Serotonin Receptors in the Hippocampus.
JO  - Science
JF  - Science
Y1  - 1981/09/25/
VL  - 213
IS  - 4515
M3  - Article
SP  - 1529
EP  - 1531
SN  - 00368075
AB  - The effects of long-term lithium administration on pre- and postsynaptic processes involved in serotonergic neurotransmission were measured in rat hippocampus and cerebral cortex. Long-term lithium administration increased both basal and potassium chloride-stimulated release of endogenous serotonin from the hippocampus but not from the cortex. Serotonergic receptor binding was reduced in the hippocampus but not in the cortex. These results suggest a mechanism by which lithium may stabilize serotonin neurotransmission. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85483628; TREISER, SUSAN L. 1; CASCIO, CAREN S. 1; O'DONOHUE, THOMAS L. 2; THOA, NGUYEN B. 2; JACOBOWITZ, DAVID M. 2; KELLAR, KENNETH J. 3; Affiliations: 1: Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C. 20007; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry; Issue Info: 9/25/1981, Vol. 213 Issue 4515, p1529; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Nakao, Y.
AU  - Matsumoto, H.
AU  - Miyazaki, T.
AU  - Watanabe, S.
AU  - Masaoka, T.
AU  - Takatsuki, K.
AU  - Kishihara, M.
AU  - Kobayashi, N.
AU  - Hattori, M.
AU  - Fujita, T.
T1  - Genetic and clinical studies of serum β2-microglobulin levels in haematological malignancies.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/10//
VL  - 46
IS  - 1
M3  - Article
SP  - 134
EP  - 141
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Sera from 244 patients with haematological malignancies were examined for β2-micro- globulin (β2m) levels. There were 142 leukaemias, 32 malignant lymphomas, three immunoblastic lymphomas, two pseudolymphomas and 65 multiple myelomas. Culture supernatants from various established cell lines were also tested. The phenotype facilitating β2m shedding from the cell surface appeared to be independent of the specific IgG heavy chain allotypes; however, a myeloma group with normal serum β2m levels showed a significant association with the specific Gm allotypes. The determination of serum β2m levels can provide valuable information on the proliferative stage of the disorders, the effectiveness of chemotherapy, and be a diagnostic aid for blastic crisis in chronic myelocytic leukaemias, and for subtyping lymphoid malignancies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SERUM
KW  - LYMPHOMAS
KW  - LYMPHOPROLIFERATIVE disorders
KW  - MULTIPLE myeloma
KW  - GENOTYPE-environment interaction
KW  - CELL membranes
KW  - DRUG therapy
N1  - Accession Number: 16011572; Nakao, Y. 1 Matsumoto, H. 2 Miyazaki, T. 2 Watanabe, S. 3 Masaoka, T. 4 Takatsuki, K. 5 Kishihara, M. 1 Kobayashi, N. 1 Hattori, M. 1 Fujita, T. 1; Affiliation:  1: Third Division, Department of Medicine, Kobe University School of Medicine, Chuoku, Kobe.  2: Department of Legal Medicine, Osaka Medical College, Osaka.  3: Department of Pathology, National Cancer Institute, Tokyo.  4: Department of Medicine, Center for Adult Diseases, Osaka.  5: First Division, Department of Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan.; Source Info: Oct1981, Vol. 46 Issue 1, p134; Subject Term: SERUM; Subject Term: LYMPHOMAS; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: MULTIPLE myeloma; Subject Term: GENOTYPE-environment interaction; Subject Term: CELL membranes; Subject Term: DRUG therapy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Small, Arnold C.
AU  - Madero, James
AU  - Gross, Howard
AU  - Teagno, Lorie
AU  - Leib, Jere
AU  - Ebert, Michael
T1  - A COMPARATIVE ANALYSIS OF PRIMARY ANOREXICS AND SCHIZOPHRENICS ON THE MMPI.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1981/10//
VL  - 37
IS  - 4
M3  - Article
SP  - 733
EP  - 736
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - This article focuses on primary anorexics and schizophrenics on the MMPI. Although only a very small number of studies have described personality testing in primary anorexia nervosa (patients), they seem to suggest a deeper personality disturbance than commonly suggested by psychiatric interview. The study of the personality dimensions of anorexia nervosa and the nosological category to which it belongs has led to very little agreement among investigators. With regard to their overall MMPI profile, patients with PAN showed a wide diversity of traits that are characteristic of character, neurotic, psychotic, and psychosomatic disorders.
KW  - PERSONALITY
KW  - APPETITE loss
KW  - MENTALLY ill
KW  - PATIENTS
KW  - SCHIZOPHRENICS
KW  - APPETITE disorders
N1  - Accession Number: 15845840; Small, Arnold C. 1 Madero, James 2 Gross, Howard 2 Teagno, Lorie 3 Leib, Jere Ebert, Michael 4; Affiliation:  1: George Mason University and Family & Child Development Services, Woodbridge, Va.  2: National Institute of Mental Health Bethesda, Maryland.  3: University of Maryland College Park, Maryland.  4: National Institute of Mental Health.; Source Info: Oct1981, Vol. 37 Issue 4, p733; Subject Term: PERSONALITY; Subject Term: APPETITE loss; Subject Term: MENTALLY ill; Subject Term: PATIENTS; Subject Term: SCHIZOPHRENICS; Subject Term: APPETITE disorders; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gillaspie Jr., A. G.
AU  - Thomas, C. A.
AU  - Prescott, B.
T1  - Inhibition of Sugarcane Mosaic Virus Symptoms on Sorghum by Microbial and Plant Polysaccharides and Their Antigenic Relationship.
T2  - Hemmung des Zuckerrohrmosaikvirus in Sorghum durch Polysaccharide von Mikroorganismcn und höheren Pflanzen.
JO  - Phytopathologische Zeitschrift
JF  - Phytopathologische Zeitschrift
Y1  - 1981/10//
VL  - 102
IS  - 2
M3  - Article
SP  - 107
EP  - 113
PB  - Wiley-Blackwell
SN  - 00319481
AB  - Polysaccharides from 23 bacterial, fungal, and higher plant sources were tested for inhibition of systemic development of sugarcane mosaic virus (SCMV) in sweet sorghum {Sorghum hicolor 'Rio'). Extracts from virus infected leaves were mixed with the polysaccharides and inoculated onto plants with an artist's airbrush. Polysaccharides from yeast cell walls and from Bacillus subtilis and Streptococcus pneumoniae Type III cell-free culture liquids inhibited SCMV-infection by 90-100% (symptom formation on treated plants compared with control plants inoculated only with SCMV) at concentrations as low as 250 μg/ml. The other polysaccharides inhibited infection by 29 % or less at concentrations as high as 2000 μg/ml. Although several of the plant and microbial polysaccharides tested are antigenically related, no relationship between inhibitory activity and antigenic properties was apparent. (English) [ABSTRACT FROM AUTHOR]
AB  - Polysaccharide von 23 Bakterien, Pilzen und höheren Pflanzen wurden auf ihre Hemmung der systemischen Entwicklung des Zuckerrohrmosaikvirus (SCMV) in Sorghum hicolor 'Rio' geprüft. Extrakte von virusinfizierten Blättern wurden mit den Polysacchariden gemischt und mit einem Pinsel auf Pflanzen geimpft. Polysaccharide aus Hefezellwänden und zellfreien Kulturfiltraten von Bacillus suhtilis und Streptococcus pneumoniae Typ III hemmten die Infektion mit SCMV zu 90 bis 100 % bei Konzentrationen von 250 μg/ml. Die übrigen Polysaccharide hemmten die Infektion um 29 % oder weniger bel Konzentration von 2000 μg/ml. Mehrere Polysaccharide von Pflanzen und Mikroorganismen waren zwar antigenisch verwandt, doch wurde keine Beziehung zwischen Hemmwirkung und Antigeneigenschaften gefunden. (German) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Phytopathologische Zeitschrift is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Polysaccharides
KW  - Sugarcane mosaic virus
KW  - Sorgo
KW  - Yeast
KW  - Bacillus subtilis
KW  - Streptococcus pneumoniae
N1  - Accession Number: 15556750; Gillaspie Jr., A. G. 1; Thomas, C. A. 1; Prescott, B. 1; Affiliations: 1: U. S. Department of Agriculture, Beltsville, Maryland, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1981, Vol. 102 Issue 2, p107; Thesaurus Term: RESEARCH; Subject Term: Polysaccharides; Subject Term: Sugarcane mosaic virus; Subject Term: Sorgo; Subject Term: Yeast; Subject Term: Bacillus subtilis; Subject Term: Streptococcus pneumoniae; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1439-0434.ep15556750
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Emilson, C. G.
AU  - Bowen, W. H.
AU  - Robrish, S. A.
AU  - Kemp, C. W.
T1  - Effect of the antibacterial agents octenidine and chlorhexidine on the plaque flora in primates.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1981/10//
VL  - 89
IS  - 5
M3  - Article
SP  - 384
EP  - 392
SN  - 0029845X
AB  - The effect of the antibacterial substance octenidine on plaque formation and on oral microflora in eight monkeys fed a sucrose diet was studied. Plaque was obtained from buccal tooth surfaces of premolars and first molars in two quadrants using a swab and a dental carver and examined using culture and fluorescent antibody procedures. A significant reduction in plaque score was observed on the buccal tooth surfaces after daily topical application of 1%, solutions of octenidine and chlorhexidine for 7 d; octenidine was more effective than chlorhexidine, Placebo treatment with water was without significant effect. Octenidine and chlorhexidine affected the plaque flora in a similar manner; the proportion of S. sanguis increased in relation to baseline levels while the population of Actinomyces, especially the group A. viscosus and. A. naeslundii, was markedly reduced. S. sanguis showed an inverse relationship to members of Actinomyces in response to the action of the antimicrobial agents. Both plaque sampling methods revealed similar changes in bacterial composition as a result of treatment. The data show that octenidine is an effective inhibitor of dental plaque and its antimicrobial and antiplaque properties make it worthy of further studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTI-infective agents
KW  - ANTIBACTERIAL agents
KW  - SUCROSE
KW  - TEETH
KW  - DENTISTRY
KW  - ANTIBIOTICS
KW  - antibacterial agents
KW  - chlorhexidine
KW  - dental plaque
KW  - flora
KW  - octenidine
KW  - primates
N1  - Accession Number: 13198775; Emilson, C. G. 1 Bowen, W. H. 1 Robrish, S. A. 1 Kemp, C. W. 1; Affiliation:  1: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.; Source Info: 1981, Vol. 89 Issue 5, p384; Subject Term: ANTI-infective agents; Subject Term: ANTIBACTERIAL agents; Subject Term: SUCROSE; Subject Term: TEETH; Subject Term: DENTISTRY; Subject Term: ANTIBIOTICS; Author-Supplied Keyword: antibacterial agents; Author-Supplied Keyword: chlorhexidine; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: flora; Author-Supplied Keyword: octenidine; Author-Supplied Keyword: primates; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06557-004
AN  - 2006-06557-004
AU  - Yarrow, Leon J.
T1  - The Many Faces of Continuity.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1981/10//
VL  - 26
IS  - 10
SP  - 746
EP  - 747
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06557-004. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Child and Family Research Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Central Nervous System; Health; Human Development; Motivation; Physical Development. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Reviewed Item: Brim, Orville G. Jr. (Ed); Kagan, Jerome (Ed). Constancy and Change in Human Development=Cambridge, Mass.: Harvard University Press, 1980 760 pp $27 50; 1980. Page Count: 2. Issue Publication Date: Oct, 1981. 
AB  - Reviews the book, Constancy and Change in Human Development by Orville G. Brim, Jr., and Jerome Kagan (Eds.) (1980). By presenting an interdisciplinary selection of topics, the editors have avoided a narrow view of the issues. Enriching the volume considerably are chapters on the central nervous system (Stein & Dawson), the endocrine system (Doering), physical health (Starneld & Pless), and physical growth (Garn). These chapters help drive home the point that the philosophical and methodological issues underlying consideration of constancy and change are not so vastly different in disciplines other than psychology and sociology. The chapters on physical health, physical growth, the central nervous system, and the endocrine system underscore the complex determinants of continuity and discontinuity, and point up the difficulties in defining the concept clearly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - central nervous system
KW  - endocrine system
KW  - human development
KW  - physical health
KW  - sociology
KW  - 1981
KW  - Central Nervous System
KW  - Health
KW  - Human Development
KW  - Motivation
KW  - Physical Development
KW  - 1981
U2  - Brim, Orville G. Jr. (Ed); Kagan, Jerome (Ed). (1980); Constancy and Change in Human Development; Cambridge, Mass.: Harvard University Press, 1980 760 pp $27 50
DO  - 10.1037/019681
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - CHO-CHUNG, YOON SANG
AU  - CLAIR, TIMOTHY
AU  - BODWIN, JEFFREY S.
AU  - BERGHOFFER, BELA
T1  - Growth Arrest and Morphological Change of Human Breast Cancer Cells by Dibutyryl Cyclic AMP and L-Arginine.
JO  - Science
JF  - Science
Y1  - 1981/10/02/
VL  - 214
IS  - 4516
M3  - Article
SP  - 77
EP  - 79
SN  - 00368075
AB  - The growth in vitro of human breast cancer cells, line MCF-7, was inhibited by a daily supplement of L-arginine (1 milligram per milliliter). Arginine acted synergistically with dibutyryl adenosine 3',S'-monophosphate (cyclic AMP) (10-6 molar) to enhance the growth inhibitory effect: the cell replication ceased completely within 2 days after treatment. The growth arrest accompanied a change in cell morphology and was preceded by increases in the cellular concentration of cyclic AMP, adenylate cyclase, and type II cyclic AMP-dependent protein kinase activities as well as a decrease of estrogen binding activity. The results suggest that growth of human breast cancer cells i's subject to cyclic AMP-mediated regulation and that arginine may play a specific role in this process. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84691885; CHO-CHUNG, YOON SANG 1; CLAIR, TIMOTHY 1; BODWIN, JEFFREY S. 1; BERGHOFFER, BELA 1; Affiliations: 1: Cellular Biochemistry Section, Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 10/ 2/1981, Vol. 214 Issue 4516, p77; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SIRES, L. R.
AU  - HRUBY, S.
AU  - ALVORD JR., E. C.
AU  - HELLSTROM, I.
AU  - HELLSTROM, K.-E.
AU  - KIES, M. W.
AU  - MARTENSON, R.
AU  - DEIBLER, G. E.
AU  - BECKMAN, E. D.
AU  - CASNELLIE, J. E.
T1  - Species Restrictions of a Monoclonal Antibody Reacting with Residues 130 to 137 in Encephalitogenic Myelin Basic Protein.
JO  - Science
JF  - Science
Y1  - 1981/10/02/
VL  - 214
IS  - 4516
M3  - Article
SP  - 87
EP  - 89
SN  - 00368075
AB  - A monoclonal antibody (immunoglobulin GJ) has been produced that reacts against myelin basic protein present in or extractedfrom the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84691889; SIRES, L. R. 1; HRUBY, S. 1; ALVORD JR., E. C. 1; HELLSTROM, I. 2; HELLSTROM, K.-E. 2; KIES, M. W. 3; MARTENSON, R. 3; DEIBLER, G. E. 3; BECKMAN, E. D. 4; CASNELLIE, J. E. 4; Affiliations: 1: Laboratory of Neuropathology, University of Washington School of Medicine, Seattle 98195; 2: Division of Tumor Immunology, Fred Hutchinson Cancer Research Center, Seattle 98104; 3: Laboratory of Myelin Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Laboratory of Molecular Pharmacology, Howard Hughes Medical Institute, Seattle 98195; Issue Info: 10/ 2/1981, Vol. 214 Issue 4516, p87; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DUMOUCHEL, WILLIAM H.
AU  - DEDRICK, ROBERT L.
AU  - RAABE, OTTO G.
T1  - Dose-Response Analyses of Bone Cancers from Radium.
JO  - Science
JF  - Science
Y1  - 1981/10/09/
VL  - 214
IS  - 4517
M3  - Article
SP  - 206
EP  - 208
SN  - 00368075
N1  - Accession Number: 84691932; DUMOUCHEL, WILLIAM H. 1; DEDRICK, ROBERT L. 2; RAABE, OTTO G. 3; Affiliations: 1: Department of Mathematics, Massachusetts Institute of Technology, Cambridge 02139; 2: National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory for Energy-Related Health Research, University of California, Davis 95616; Issue Info: 10/ 9/1981, Vol. 214 Issue 4517, p206; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - JOSEPH, J. A.
AU  - ENGEL, B. T.
T1  - Instrumental Control of Cardioacceleration Induced by Central Electrical Stimulation.
JO  - Science
JF  - Science
Y1  - 1981/10/16/
VL  - 214
IS  - 4518
M3  - Article
SP  - 341
EP  - 343
SN  - 00368075
AB  - Each of four monkeys (Macaca mulatta) was operantly conditioned to slow and to speed heart rate through a shock-avoidance procedure. During these sessions, electrical brain stimulation that produced tachycardia and pressor responses was delivered on alternate, 64-second segments to one of several brain regions. All animals were able to attenuate the increases in heart rate produced by brain stimulation during the slowing sessions when posterior hypothalamic and striatal regions were stimulated but not when anterior hypothalamic or subthalamic areas were stimulated. During speeding or control sessions during which heart rate was monitored, brain stimulation continued to increase heart rate. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87477583; JOSEPH, J. A. 1; ENGEL, B. T. 1; Affiliations: 1: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; Issue Info: 10/16/1981, Vol. 214 Issue 4518, p341; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - REDDY, E. PREMKUMAR
AU  - SMITH, MARY JANE
AU  - AARONSON, STUART A.
T1  - Complete Nucleotide Sequence and Organization of the Moloney Murine Sarcoma Virus Genome.
JO  - Science
JF  - Science
Y1  - 1981/10/23/
VL  - 214
IS  - 4519
M3  - Article
SP  - 445
EP  - 450
SN  - 00368075
AB  - The complete nucleotide sequence of a mammalian transforming retrovirus, Moloney murine sarcoma virus, has been determined. MSV, a recombinant virus derived of helper viral and cellular sequences, possesses termini resembling prokaryotic transposable elements. The viral genome has the coding capacity for the Moloney murine leukemia virus gag gene product and contains large deletions in pol and env genes. A large open reading frame encompassing its cell-derived sequences codes for its putative transforming protein. The nature of some of the important domains in the viral genome has been established, and their structure is discussed in relation to their function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84691969; REDDY, E. PREMKUMAR 1; SMITH, MARY JANE 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 10/23/1981, Vol. 214 Issue 4519, p445; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pastan, Ira H.
AU  - Willingham, Mark C.
T1  - Journey to the Center of the Cell: Role of the Receptosome.
JO  - Science
JF  - Science
Y1  - 1981/10/30/
VL  - 214
IS  - 4520
M3  - Article
SP  - 504
EP  - 509
SN  - 00368075
N1  - Accession Number: 84706819; Pastan, Ira H. 1; Willingham, Mark C. 1; Affiliations: 1: laboratory of molecular biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 10/30/1981, Vol. 214 Issue 4520, p504; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LEVIN, PHILIP
AU  - JANDA, JEAN K.
AU  - JOSEPH, JAMES A.
AU  - INGRAM, DONALD K.
AU  - ROTH, GEORGE S.
T1  - Dietary Restriction Retards the Age-Associated Loss of Rat Striatal Dopaminergic Receptors.
JO  - Science
JF  - Science
Y1  - 1981/10/30/
VL  - 214
IS  - 4520
M3  - Article
SP  - 561
EP  - 562
SN  - 00368075
AB  - In male Wistar rats subjected to dietary restriction by alternate days of feeding andfasting the normal age-associated loss of striatal dopamine receptors in the brain was substantially retarded. The mean survival time of the rats on the restricted diet was increased by approximately 40 percent compared to control rats given free access to food. Dopamine receptor concentrations in striata of 24-monthold rats that had been on a restricted diet since weaning were 50 percent higher than those of control animals of the same age, and essentially comparable to 3- to 6- month-old control rats. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84706844; LEVIN, PHILIP 1; JANDA, JEAN K. 1; JOSEPH, JAMES A. 1; INGRAM, DONALD K. 1; ROTH, GEORGE S. 1; Affiliations: 1: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; Issue Info: 10/30/1981, Vol. 214 Issue 4520, p561; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GOLDBERG, STEVEN R.
AU  - SPEALMAN, ROGER D.
AU  - GOLDBERG, DONNA M.
T1  - Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine.
JO  - Science
JF  - Science
Y1  - 1981/10/30/
VL  - 214
IS  - 4520
M3  - Article
SP  - 573
EP  - 575
SN  - 00368075
AB  - Squirrel monkeys pressed a lever at high rates under a second-order schedule of reinforcement in which lever pressing produced a brief visual stimulus that was occasionally contiguous with an intravenous injection of nicotine. The rate of lever pressing could be markedly reduced either by substituting saline for nicotine injections or by blocking the effects of nicotine with mecantylamine. The rate of lever pressing could also be reduced by eliminating the briefvisual stimulus. These results show that nicotine can function as an effective reinforcer under a second-order schedule of drug self-administration and that an environmental stimulus associated with nicotine intake can contribute to the maintenance of persistent drug-seeking behavior. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84706850; GOLDBERG, STEVEN R. 1; SPEALMAN, ROGER D. 2; GOLDBERG, DONNA M. 2; Affiliations: 1: National Institute on Drug Abuse, Addiction Research Center, Post Office Box 5200, Baltimore, Maryland 21224; 2: Harvard Medical School and New England Regional Primate Research Center, Southborough, Massachusetts 01772; Issue Info: 10/30/1981, Vol. 214 Issue 4520, p573; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Deshazo, R. D.
AU  - Ewel, Cynthia
AU  - Londono, Sonnya
AU  - Metzger, Z.
AU  - Hoffeld, J. T.
AU  - Oppenheim, J. J.
T1  - Evidence for the involvement of monocyte-derived toxic oxygen metabolites in the lymphocyte dysfunction of Hodgkin's disease.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1981/11//
VL  - 46
IS  - 2
M3  - Article
SP  - 313
EP  - 320
PB  - Wiley-Blackwell
SN  - 00099104
AB  - This study was performed to see if adherent cell-derived toxic oxygen metabolites contribute to the suppression of mononuclear cell blastogenic responses in Hodgkin's disease. Peripheral blood mononuclear cells from 10 patients with Hodgkin's disease were stimulated in culture with the mitogen PHA in the presence of the prostaglandin inhibitor indomethacin and the antioxidants catalase or vitamin E. Patient lymphocytes showed significant increases in PHA-induced proliferation at all PHA doses when cultured with indomethacin. Further augmentation of lymphocyte proliferation was achieved with the addition of catalase or vitamin E to indomethacin in the culture system. The increases in proliferation seen on culture with these agents were greatest in patients with more depressed initial PHA responses. When adherent cells were removed before culture, the agents no longer facilitated increases in proliferation. These data suggest that abnormal lymphocyte proliferative responses seen in Hodgkin's disease may result in part from the excessive production of toxic oxygen metabolites as well as prostaglandins by adherent cell populations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - METABOLITES
KW  - LEUCOCYTES
KW  - ISOPENTENOIDS
KW  - HODGKIN'S disease
KW  - PROSTAGLANDINS
N1  - Accession Number: 15955000; Deshazo, R. D. 1,2,3 Ewel, Cynthia 1,2,3 Londono, Sonnya 1,2,3 Metzger, Z. 1,2,3 Hoffeld, J. T. 1,2,3 Oppenheim, J. J. 1,2,3; Affiliation:  1: Clinical Immunology Section, Tulane University School of Medicine, New Orleans, Louisiana.  2: Laboratory of Experimental Immunology, Walter Reed Army Medical Center, Washington, DC.  3: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Nov1981, Vol. 46 Issue 2, p313; Subject Term: LYMPHOCYTES; Subject Term: METABOLITES; Subject Term: LEUCOCYTES; Subject Term: ISOPENTENOIDS; Subject Term: HODGKIN'S disease; Subject Term: PROSTAGLANDINS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06556-021
AN  - 2006-06556-021
AU  - Fox, Bernard H.
T1  - Childhood Cancer: A Discipline in its Infancy.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1981/11//
VL  - 26
IS  - 11
SP  - 850
EP  - 850
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06556-021. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Fox, Bernard H.; National Cancer Institute, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Clinicians; Neoplasms; Psychodynamics. Classification: Cancer (3293); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Kellerman, Jonathan (Ed). Psychological Aspects of Childhood Cancer=Springfield, Ill.: Charles C. Thomas, 1980 333 pp $32.50; 1980. References Available: Y. Page Count: 1. Issue Publication Date: Nov, 1981. 
AB  - Reviews the book, Psychological Aspects of Childhood Cancer by Jonathan Kellerman (Ed ) (1980). This book of contributions to the psychological management of young cancer patients is a creditable effort in a relatively new field. Kellerman's objective in collecting these contributions was to 'provide a comprehensive and practical guide to the psychological management of children with cancer.' The two parts of this book-'Impact of Illness and Treatment' (about 60%) and 'Clinical Approaches'--are somewhat different from each other, the second section containing more focused management suggestions, as in McCue's excellent 'Preparing Children for Medical Procedures.' The insightful clinician can gain much from both sections. As for Kellerman's objectives, the book provided a reasonably comprehensive and fairly practical guide to the psychological management of children with cancer. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological management
KW  - cancer patients
KW  - children
KW  - psychological aspects
KW  - clinical psychology
KW  - 1981
KW  - Clinical Psychology
KW  - Clinicians
KW  - Neoplasms
KW  - Psychodynamics
KW  - 1981
U2  - Kellerman, Jonathan (Ed). (1980); Psychological Aspects of Childhood Cancer; Springfield, Ill.: Charles C. Thomas, 1980 333 pp $32.50
DO  - 10.1037/019780
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-24299-001
AN  - 2009-24299-001
AU  - Schneider, Stanley F.
T1  - Where have all the students gone? Positions of psychologists trained in clinical/services programs.
T3  - Human Resources in Psychology
JF  - American Psychologist
JO  - American Psychologist
JA  - Am Psychol
Y1  - 1981/11//
VL  - 36
IS  - 11
SP  - 1427
EP  - 1449
CY  - US
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
AD  - Schneider, Stanley F., National Institute of Mental Health, Psychology Education Branch, Division of Manpower and Training Programs, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2009-24299-001. PMID: 7325480 Partial author list: First Author & Affiliation: Schneider, Stanley F.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20091221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Geography; Graduate Psychology Education; Psychologists. Minor Descriptor: Clinical Psychology Graduate Training; Mental Health Services. Classification: Professional Education & Training (3410). Population: Human (10). Location: US. References Available: Y. Page Count: 23. Issue Publication Date: Nov, 1981. 
AB  - This article presents a variety of findings derived from two outcome studies of psychologists who received their doctorates from clinical/services training programs supported by the National Institute of Mental Health in the years 1968-1980. Comparative data are presented regarding the initial positions and geographical distribution of graduates during this period. Despite some erosion in the market for academic faculty positions, the results show a consistent and extraordinary degree of employment consonant with training and virtually no unemployment. Two thirds of the graduates have jobs in a range of organized settings for service, and over 22% of the remainder are in academic or research positions. The most recent study enables analyses of certain factors influencing the initial location of graduates. Particular attention is paid to three topics of national concern. Criteria are developed for designating rural/small town service providers, and evidence is presented showing that programmatic implementation of this priority in training yields results. The issue of clinical research is discussed; the scope of such research and the extent to which students may be engaged in it are examined. Data are provided on the recruitment of minority students, and factors affecting minority student retention and completion of training are discussed. Outcomes of master's-level training programs are presented separately, and characteristics of training at that level are contrasted with those in doctoral programs. In a concluding section, the findings are discussed in the context of changes in psychology graduate education during the past generation, some current value dilemmas that affect education are explored, and certain implications of the revised national policies for support of clinical training in mental health are reviewed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - current positions
KW  - psychologists
KW  - clinical/services training program doctorates
KW  - geographical distribution
KW  - 1981
KW  - Employment Status
KW  - Geography
KW  - Graduate Psychology Education
KW  - Psychologists
KW  - Clinical Psychology Graduate Training
KW  - Mental Health Services
KW  - 1981
DO  - 10.1037/0003-066X.36.11.1427
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Filer, David
AU  - Dhar, Ravi
AU  - Furano, Anthony V.
T1  - The Conservation of DNA Sequences over Very Long Periods of Evolutionary Time.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/11/02/
VL  - 120
IS  - 1
M3  - Article
SP  - 69
EP  - 77
PB  - Wiley-Blackwell
SN  - 00142956
AB  - In the present study we tried to determine whether the presence of DNA sequences homologous to the Escherichia coli tuf gene (encodes peptide chain elongation factor Tu) in many taxonomically-unrelated prokaryotes is due to selective pressure for these sequences or due to the transfer of chromosomal material subsequent to the divergence of the genera from their progenitors. We found that the degree of sequence homology to the DNA immediately adjacent to the E. coli tuf A gene is either nonexistent or much less than that found for the tuf gene. Furthermore, the tuf-homologous sequences present in one prokaryote were found to be in large part the same as or a subset of those present in others. That is, various, prokaryotes share a common subset of tuf-homologous sequences. These findings suggest that strong selective pressure and not recent intergeneric chromosomal transfer is responsible for the ubiquitos presence of certain tuf-homologous sequences. Because the genetic code is degenerate, DNA sequence need not be conserved to conserve protein sequence. Therefore, if the only function of these sequences is to encode protein, their persistence must mean that in some instances codon sequence is selected for. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEOTIDE sequence
KW  - ESCHERICHIA coli
KW  - AMINO acid sequence
KW  - BIOCHEMISTRY
KW  - GENES
KW  - PROKARYOTES
N1  - Accession Number: 13923268; Filer, David 1 Dhar, Ravi 1 Furano, Anthony V. 1; Affiliation:  1: Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, and Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 11/2/81, Vol. 120 Issue 1, p69; Subject Term: NUCLEOTIDE sequence; Subject Term: ESCHERICHIA coli; Subject Term: AMINO acid sequence; Subject Term: BIOCHEMISTRY; Subject Term: GENES; Subject Term: PROKARYOTES; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Waxman, Phyllis G.
AU  - Del Campo, Anthony A.
AU  - Lowe, Michael C.
AU  - Hamel, Ernest
T1  - Induction of Polymerization of Purified Tubulin by Sulfonate Buffers.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/11/02/
VL  - 120
IS  - 1
M3  - Article
SP  - 129
EP  - 136
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Interaction of both purified tubulin and microtubule protein (tubulin plus associated proteins) with two commonly used sulfonate buffers were examined. 1,4-Piperazineethanesulfonate (Pipes) and 4-morpholineethanesulfonate (Mes) at high concentrations induce the polymerization of purified tubulin in reactions requiring only buffer, tubulin and GTP. While both reactions were temperature-dependent, old, reversible and inhibited by GDP, colchicine or Ca2+, there were significant differences between them. Substantially lower tubulin and buffer concentrations were required for Pipes-induced polymerization; and turbidity was much more intense in the Pipes-induced than in the Mes-induced reaction at the same protein concentration Electron microscopy demonstrated that for the most part typical smooth-walled microtubules were formed in Mes, while aberrant forms were the predominant structures formed in Pipes. When the polymerization of microtubule protein was examined as a function of buffer concentration, biphasic patterns were observed with both Pipes and Mes; polymerization occurred at both low and high, but not intermediate, buffer concentrations. The turbidity observed at high concentrations of Pipes greatly exceeded that at low concentrations. With Mes, equivalent turbidity developed at both high and low buffer concentrations. Although associated proteins copolymerized with tubulin at low buffer concentrations, they were exclude from the polymerized material at high buffer concentrations. Pipes and Mes were compared to sodium phosphate, Tris/HCl and imidazole/HCl buffers at 0.1 M in several polymerization systems using both purified tubulin and microtubulate protein. The sulfonate buffers were invariably associated with more vigorous reactions than the other buffers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TUBULINS
KW  - POLYMERIZATION
KW  - SULFONATES
KW  - BIOCHEMISTRY
KW  - CHEMICAL reactions
KW  - MICROTUBULES
N1  - Accession Number: 13924015; Waxman, Phyllis G. 1 Del Campo, Anthony A. 1 Lowe, Michael C. 1 Hamel, Ernest 1; Affiliation:  1: Laboratory of Medicinal Chemistry and Biology and the Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 11/2/81, Vol. 120 Issue 1, p129; Subject Term: TUBULINS; Subject Term: POLYMERIZATION; Subject Term: SULFONATES; Subject Term: BIOCHEMISTRY; Subject Term: CHEMICAL reactions; Subject Term: MICROTUBULES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - LEVINE, ROBERT A.
AU  - MILLER, LEONARD P.
AU  - LOVENBERG, WALTER
T1  - Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine Synthesis.
JO  - Science
JF  - Science
Y1  - 1981/11/20/
VL  - 214
IS  - 4523
M3  - Article
SP  - 919
EP  - 921
SN  - 00368075
AB  - The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84711984; LEVINE, ROBERT A. 1; MILLER, LEONARD P. 1; LOVENBERG, WALTER 1; Affiliations: 1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/20/1981, Vol. 214 Issue 4523, p919; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FISHMAN, MARK C.
AU  - ZIMMERMAN, EARL A.
AU  - SLATER, EVE E.
T1  - Renin and Angiotensin: The Complete System Within the Neuroblastoma x Glioma Cell.
JO  - Science
JF  - Science
Y1  - 1981/11/20/
VL  - 214
IS  - 4523
M3  - Article
SP  - 921
EP  - 923
SN  - 00368075
AB  - Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108- 15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum wvithdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84711985; FISHMAN, MARK C. 1; ZIMMERMAN, EARL A. 2; SLATER, EVE E. 3; Affiliations: 1: Laboratory of Developmental Biology, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032; 3: Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02114; Issue Info: 11/20/1981, Vol. 214 Issue 4523, p921; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LOZOVSKY, DAVID
AU  - SALLER, CHARLES F.
AU  - KOPIN, IRWIN J.
T1  - Dopamine Receptor Binding Is Increased in Diabetic Rats.
JO  - Science
JF  - Science
Y1  - 1981/11/27/
VL  - 214
IS  - 4524
M3  - Article
SP  - 1031
EP  - 1033
SN  - 00368075
AB  - The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84706987; LOZOVSKY, DAVID 1; SALLER, CHARLES F. 1; KOPIN, IRWIN J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 11/27/1981, Vol. 214 Issue 4524, p1031; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DVORAK, JAMES A.
AU  - CRANE, MARK ST. J.
T1  - Vertebrate Cell Cycle Modulates Infection by Protozoan Parasites.
JO  - Science
JF  - Science
Y1  - 1981/11/27/
VL  - 214
IS  - 4524
M3  - Article
SP  - 1034
EP  - 1036
SN  - 00368075
AB  - Synchronized HeLa cell populations were exposed to Trypanosoma cruzi or Toxoplasma gondii, obligate intracellular protozoan parasites that cause Chagas' disease and toxoplasmosis, respectively, in humans. The ability of the two parasites to infect HeLa cells increased as the HeLa cells proceeded from the GI phase to the S phase of their growth cycle and decreased as the cells entered G2-M. Characterization of the S-phase cell surface components responsible for this phenomenon could be beneficial in the development of vaccines against these parasitic diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84706989; DVORAK, JAMES A. 1; CRANE, MARK ST. J. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/27/1981, Vol. 214 Issue 4524, p1034; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Sondik, Edward J.
AU  - Kristein, Marvin M.
T1  - Estimating Costs of Illness and Injuries: A Criticism.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1981/12//
VL  - 71
IS  - 12
M3  - Article
SP  - 1392
EP  - 1393
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents a criticism on an article by Hartunian, et. al. about estimating costs of injuries and illness. The authors reflect that the article presented a dichotomy of methodologies that could confuse lawmakers. They reflect that estimates of cost of illness is very critical in policy making of health issues and focus on methodologies of estimating cost of illness. They opine that the incidence approach and the prevalence approach suggested by Hartunian's group are both variants of the human capital approach and contend that both the prevalence approach and incidence approach are inappropriate or unsuitable when ongoing treatment costs is at issue. They suggest that the human capital method provides reasonable comparative estimates of the potential gains.
KW  - HUMAN capital
KW  - MEDICAL care costs
KW  - MEDICAL economics
KW  - CAPITATION fees (Medical care)
KW  - HOSPITAL costs
KW  - MEDICAL care
KW  - MEDICAL care costs -- Law & legislation
KW  - COST estimates
KW  - MEDICAL laws & legislation
N1  - Accession Number: 4950375; Sondik, Edward J. 1 Kristein, Marvin M. 2; Affiliation:  1: Chief, Program Analysis and Evaluation Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20205  2: State University of New York, Stony Brook; Source Info: Dec1981, Vol. 71 Issue 12, p1392; Subject Term: HUMAN capital; Subject Term: MEDICAL care costs; Subject Term: MEDICAL economics; Subject Term: CAPITATION fees (Medical care); Subject Term: HOSPITAL costs; Subject Term: MEDICAL care; Subject Term: MEDICAL care costs -- Law & legislation; Subject Term: COST estimates; Subject Term: MEDICAL laws & legislation; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Sondik, Edward
AU  - Kristein, Marvin M.
T1  - A Rejoinder.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1981/12//
VL  - 71
IS  - 12
M3  - Letter
SP  - 1408
EP  - 1408
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "Estimating Costs of Illness or Injuries," by Nelson S. Hartunian, et. al.
KW  - LETTERS to the editor
KW  - COST estimates
N1  - Accession Number: 4950449; Sondik, Edward 1 Kristein, Marvin M. 2; Affiliation:  1: Chief, Program Analysis and Evaluation Branch, MD 20205  2: Visiting Economist, National Heart, Lung, and Blood Institute Bethesda, MD 20205; Source Info: Dec1981, Vol. 71 Issue 12, p1408; Subject Term: LETTERS to the editor; Subject Term: COST estimates; Number of Pages: 1/2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Slomczynski, Kazimierz M.
AU  - Miller, Joanne
AU  - Kohn, Melvin L.
T1  - STRATIFICATION, WORK, AND VALUES: A POLISH-UNITED STATES COMPARISON.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1981/12//
VL  - 46
IS  - 6
M3  - Article
SP  - 720
EP  - 744
SN  - 00031224
AB  - In Poland and the United States social stratification is related to parental values and to social orientations, with men of higher position more likely to value self-direction and to have a social orientation consonant with valuing self-direction: a nonauthoritarian perspective, personally responsible standards of morality, and trustfulness. These relationships result in large measure from the greater opportunities afforded by higher position to be self-directed in one's work. In the United States, higher social-stratification position is associated with more favorable self-conceptions, largely as a result of the greater opportunities for occupational self-direction that higher position affords. In Poland, lower position is associated with greater self-confidence and less anxiety. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL stratification
KW  - VALUES (Ethics)
KW  - ETHICS
KW  - SOCIAL status
KW  - UNITED States
KW  - POLAND
N1  - Accession Number: 14764181; Slomczynski, Kazimierz M. 1; Miller, Joanne 2; Kohn, Melvin L. 2; Affiliations: 1: University of Warsaw and National institute of Mental Health.; 2: National Institute of Mental Health.; Issue Info: Dec81, Vol. 46 Issue 6, p720; Subject Term: SOCIAL stratification; Subject Term: VALUES (Ethics); Subject Term: ETHICS; Subject Term: SOCIAL status; Subject: UNITED States; Subject: POLAND; Number of Pages: 25p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Kunz, Bernard A.
AU  - Haynes, Robert H.
T1  - PHENOMENOLOGY AND GENETIC CONTROL OF MITOTIC RECOMBINATION IN YEAST.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1981/12//
VL  - 15
M3  - Article
SP  - 57
EP  - 89
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Examines the relations between DNA repair and recombination in yeast.  Analysis of typical dose-response curves for ultraviolet light (UV)-induced gene conversion and mitotic crossing-over; Presentation of a list of mutations known to affect recombination in yeast.
KW  - YEAST
KW  - MITOSIS
KW  - CELL cycle
KW  - GENETIC recombination
KW  - GENETICS
KW  - CELL division (Biology)
N1  - Accession Number: 12347792; Kunz, Bernard A. 1 Haynes, Robert H. 2; Affiliation:  1: National Institute of Environmental Health Sciences, Laboratory of Molecular Genetics, North Carolina  2: Department of Biology, York University, Toronto, Ontario, Canada; Source Info: 1981, Vol. 15, p57; Subject Term: YEAST; Subject Term: MITOSIS; Subject Term: CELL cycle; Subject Term: GENETIC recombination; Subject Term: GENETICS; Subject Term: CELL division (Biology); NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 33p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nash, Howard A.
T1  - INTEGRATION AND EXCISION OF BACTERIOPHAGE λ THE MECHANISM OF CONSERVATIVE SITE SPECIFIC RECOMBINATION.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1981/12//
VL  - 15
M3  - Article
SP  - 143
EP  - 167
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Discusses the mechanism of conservative site-specific recombination in a bacteriophage lambda.  Study of the integration/excision cycle of the bacteriophage; Organization of the studies around a model for integration and excision; Developments that elaborate the mechanism of the integration and excision reactions.
KW  - BACTERIOPHAGES
KW  - GENETIC recombination
KW  - CHROMOSOMES
KW  - BACTERIAL transformation
KW  - GENETIC transformation
KW  - GENETICS
N1  - Accession Number: 12347825; Nash, Howard A. 1; Affiliation:  1: Laboratory of Neurochemistry, National Institute of Mental Health Bethesda, Maryland; Source Info: 1981, Vol. 15, p143; Subject Term: BACTERIOPHAGES; Subject Term: GENETIC recombination; Subject Term: CHROMOSOMES; Subject Term: BACTERIAL transformation; Subject Term: GENETIC transformation; Subject Term: GENETICS; Number of Pages: 25p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Moment, Gairdner
T1  - EVOLUTION/CREATION DEBATE.
JO  - BioScience
JF  - BioScience
Y1  - 1981/12//
VL  - 31
IS  - 11
M3  - Letter
SP  - 788
EP  - 788
SN  - 00063568
AB  - A letter to the editor is presented in response to the article ""Evolution/Creation Debate: A Time For Truth," by R.C. Lewontin, previously published in the September 1981 issue of the periodical "BioScience."
KW  - Evolution (Biology)
KW  - Letters to the editor
N1  - Accession Number: 28051341; Moment, Gairdner 1; Affiliations: 1 : Professor of Biology Emeritus, Goucher College, Guest Scientist, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224;  Source Info: Dec1981, Vol. 31 Issue 11, p788; Thesaurus Term: Evolution (Biology); Subject Term: Letters to the editor; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 441
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Emilson, C. G.
AU  - Bowen, W. H.
T1  - Microbial analyses of dental plaque of monkeys (Macaca fascicularis) using fluorescent antibody techniques.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1981/12//
VL  - 89
IS  - 6
M3  - Article
SP  - 458
EP  - 462
SN  - 0029845X
AB  - Selected microbial components in supragingival dental plaque from recently captured monkeys were determined. Using specific fluorescent antibody (FA) conjugates S. sanguis was found to constitute an average of 11.8% of all cells. The population of Actinomyces accounted for 20.7% (range 5- 31) with A. viscosus and A. naeslundii as predominant species. Few lactobacilli were encountered. S. mutans was not detected in any specimens when examined by culture and FA. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL plaque
KW  - ACTINOMYCES
KW  - IMMUNOGLOBULINS
KW  - MONKEYS as laboratory animals
KW  - CELL culture
KW  - DIAGNOSTIC specimens
KW  - dental plaque
KW  - microbiology
KW  - monkeys
KW  - oral
N1  - Accession Number: 13200305; Emilson, C. G. 1 Bowen, W. H. 2; Affiliation:  1: Department of Cariology, Faculty of Odontology, University of Gothenburg, S-400 33 Gothenburg 33, Sweden.  2: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, U.S.A.; Source Info: 1981, Vol. 89 Issue 6, p458; Subject Term: DENTAL plaque; Subject Term: ACTINOMYCES; Subject Term: IMMUNOGLOBULINS; Subject Term: MONKEYS as laboratory animals; Subject Term: CELL culture; Subject Term: DIAGNOSTIC specimens; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: microbiology; Author-Supplied Keyword: monkeys; Author-Supplied Keyword: oral; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - CHEN, YUAN-TSONG
AU  - MATTISON, DONALD R.
AU  - FEIGENBAUM, LIONEL
AU  - FUKUI, HENRY
AU  - SCHULMAN, JOSEPH D.
T1  - Reduction in Oocyte Number Following Prenatal Exposure to a Diet High in Galactose.
JO  - Science
JF  - Science
Y1  - 1981/12/04/
VL  - 214
IS  - 4525
M3  - Article
SP  - 1145
EP  - 1147
SN  - 00368075
AB  - When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the off spring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84704820; CHEN, YUAN-TSONG 1,2; MATTISON, DONALD R. 1,2; FEIGENBAUM, LIONEL 1,2; FUKUI, HENRY 3; SCHULMAN, JOSEPH D. 1; Affiliations: 1: National Institute of Child Health and Human Development; 2: National Institutes of Health, Bethesda, Maryland 20205; 3: National Eye Institute, National Institutes of Health; Issue Info: 12/ 4/1981, Vol. 214 Issue 4525, p1145; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - POTTER, MICHAEL
T1  - Mammalian Genetics and Cancer.
JO  - Science
JF  - Science
Y1  - 1981/12/11/
VL  - 214
IS  - 4526
M3  - Article
SP  - 1233
EP  - 1234
SN  - 00368075
N1  - Accession Number: 84704845; POTTER, MICHAEL 1; Affiliations: 1: Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1233; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GHISELLI, GIANCARLO
AU  - SCHAEFER, ERNST J.
AU  - GASCON, PEDRO
AU  - BREWER JR., H. BRYAN
T1  - Type III Hyperlipoproteinemia Associated with Apolipoprotein E Deficiency.
JO  - Science
JF  - Science
Y1  - 1981/12/11/
VL  - 214
IS  - 4526
M3  - Article
SP  - 1239
EP  - 1241
SN  - 00368075
AB  - Subjects with type III hyperlipoproteinemia develop premature atherosclerosis and have hyperlipidemia due to an increase in cholesterol-rich very low density lipoproteins (VLDL) of abnormal electrophoretic mobility. Apolipoprotein E is a major protein constituent of VLDL and appears to be important for the hepatic uptake of triglyceride-rich lipoproteins. A new kindred of patients with type III hyperlipoproteinemia is described in which no plasma apolipoprotein E could be detected, consistent with the concept that type III hyperlipoproteinemia may be due to an absence or striking deficiency of apolipoprotein E. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84704852; GHISELLI, GIANCARLO 1; SCHAEFER, ERNST J. 1; GASCON, PEDRO 1; BREWER JR., H. BRYAN 1; Affiliations: 1: Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1239; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MOODY, TERRY W.
AU  - PERT, CANDACE B.
AU  - GAZDAR, ADI F.
AU  - CARNEY, DESMOND N.
AU  - MINNA, JOHN D.
T1  - High Levels of Intracellular Bombesin Characterize Human Small-Cell Lung Carcinoma.
JO  - Science
JF  - Science
Y1  - 1981/12/11/
VL  - 214
IS  - 4526
M3  - Article
SP  - 1246
EP  - 1248
SN  - 00368075
AB  - "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84704855; MOODY, TERRY W. 1; PERT, CANDACE B. 2; GAZDAR, ADI F. 3; CARNEY, DESMOND N. 3; MINNA, JOHN D. 3; Affiliations: 1: Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037; 2: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Medical Oncology Branch, National Cancer Institute, and National Naval Medical Center, Bethesda 20014; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1246; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TRAUGOTT, UTE
AU  - SHEVACH, E.
AU  - CHIBA, J.
AU  - STONE, J. H.
AU  - RAINE, C. S.
T1  - Autoimmune Encephalomyelitis: Simultaneous Identification of T and B Cells in the Target Organ.
JO  - Science
JF  - Science
Y1  - 1981/12/11/
VL  - 214
IS  - 4526
M3  - Article
SP  - 1251
EP  - 1253
SN  - 00368075
AB  - Monoclonal antibodies to guinea pig T cells and antibodies to guinea pig immunoglobulin G were used in immunofluorescence studies to identify T and B cells in central nervous system tissue from guinea pigs with acute autoimmune encephalomyelitis. T cells appeared before B cells and were distributed within the white matter parenchyma, while B cells remained in perivascular spaces. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84704857; TRAUGOTT, UTE 1; SHEVACH, E. 2; CHIBA, J. 2; STONE, J. H. 2; RAINE, C. S. 3; Affiliations: 1: Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461; 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Departments of Pathology (Neuropathology) and Neuroscience, and Rose F. Kennedy Center for Research, Mental Retardation and Human Development, Albert Einstein College of Medicine; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1251; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Marcus, Carol J.
AU  - Laughlin, Catherine A.
AU  - Carter, Barrie J.
T1  - Adeno-Associated Virus RNA Transcription in vivo.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1981/12/15/
VL  - 121
IS  - 1
M3  - Article
SP  - 147
EP  - 154
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have studied RNA transcripts of the defective parvovirus, adeno-associated virus (AAV) present in poly-(A)rich and poly-(A)free fractions of nuclear and cytoplasmic RNA prepared from cells infected together with a helper adenovirus. Cytoplasmic poly-(A)rich RNA contains three overlapping spliced AAV RNAs having sizes of 3.9 × 103, 3.3 × 103 and 2.3 × 103 bases respectively. The nuclear precursors of these RNAs appear to be the coterminal unspliced poly(A)-rich RNAs containing 4.2 × 103, 3.6 × 103 and 2.6 × 103 bases respectively. These unspliced RNAs were also found in the cytoplasm. The nuclear poly(A)-free RNA contained a heterogenous population of AAV RNAs that were generally smaller than 2.3 × 103 bases. In addition, the Hirt pellet fraction of the nuclear RNA contained two discrete AAV poly(A)-free RNAs having sizes of 2.5 × 103 and 2.8 × 103 bases. The 4.2 × 103 and 3.6 × 103-base unspliced RNAs are more abundant than the coterminal 3.9 × 103 and 3.3 × 103-base spliced RNAs whereas the 2.3 × 103-base spliced RNA is much more abundant than the 2.6 × 103-base unspliced RNA. Thus, the cytoplasmic abundance of the AAV spliced RNAs appears to be controlled in part by the post-transcriptional events of splicing or message stability. We also analysed the effects of AAV defective-interfering genomes upon AAV transcription. These studies showed that when synthesis of standard AAV genomes was inhibited more than 10-fold by defective-interfering genomes there was no significant effect on the types or amounts of AAV RNA transcripts which accumulated. These observations indicate that interference by defective-interfering genomes occurs mostly at the level of DNA replication rather than transcription. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEIC acids
KW  - PARVOVIRUSES
KW  - DNA viruses
KW  - CYTOPLASM
KW  - RNA
KW  - GENES
KW  - DNA replication
N1  - Accession Number: 15800666; Marcus, Carol J. 1 Laughlin, Catherine A. 1 Carter, Barrie J. 1; Affiliation:  1: Laboratory of Experimental Pathology, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.; Source Info: 12/15/81, Vol. 121 Issue 1, p147; Subject Term: NUCLEIC acids; Subject Term: PARVOVIRUSES; Subject Term: DNA viruses; Subject Term: CYTOPLASM; Subject Term: RNA; Subject Term: GENES; Subject Term: DNA replication; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KNECHT, MICHAEL
AU  - CATT, KEVIN J.
T1  - Gonadotropin-Releasing Hormone: Regulation of Adenosine 3',5'-.Monophosphate in Ovarian Granulosa Cells.
JO  - Science
JF  - Science
Y1  - 1981/12/18/
VL  - 214
IS  - 4527
M3  - Article
SP  - 1346
EP  - 1348
SN  - 00368075
AB  - The antigonadal effects of gonadotropin-releasing hormone in ovarian granulosa cells are due to attenuation of the adenosine 3',5'-monophosphate (cyclic AMP) response to follicle-stimulating hormone. Agonists of gonadotropin-releasing hormone progressively inhibit adenylate cyclase and stimulate phosphodiesterase activities in cultured granulosa cells, indicating that blockade of gonadotropin action is attributable to the combined effects of decreased production and increased degradation of cyclic AMP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85345814; KNECHT, MICHAEL 1; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 12/18/1981, Vol. 214 Issue 4527, p1346; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FISHER, R. S.
AU  - PERSSON, B.-E.
AU  - SPRING, K. R.
T1  - Epithelial Cell Volume Regulation: Bicarbonate Dependence.
JO  - Science
JF  - Science
Y1  - 1981/12/18/
VL  - 214
IS  - 4527
M3  - Article
SP  - 1357
EP  - 1359
SN  - 00368075
AB  - When Necturus gallbladder epithelial cells are osmotically shrunken, they rapidly return to their original volume despite the continued presence of a hypertonic bathing solution. This volume-regulatoiy process requires bicarbonate ions in the bathing solutions and is associated with the uptake of chloride ions. Volume-regulatory increase by epithelial cells is probably due to the parallel operation of sodium-hydrogen and chloride-bicarbonate exchangers in the apical cell membrane. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85345819; FISHER, R. S. 1; PERSSON, B.-E. 1; SPRING, K. R. 1; Affiliations: 1: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 12/18/1981, Vol. 214 Issue 4527, p1357; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-12929-000
AN  - 9999-12929-000
AU  - Cannon-Spoor, H. Eleanor
AU  - Potkin, Steven G.
AU  - Wyatt, Richard Jed
T1  - Premorbid Adjustment Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1982///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-12929-000. Acronyms: PAS. Partial author list: First Author & Affiliation: Cannon-Spoor, H. Eleanor; Saint Elizabeths Hospital, National Institute of Mental Health, Division of Special Mental Health Research, Adult Psychiatry Branch, Washington, District of Columbia, United States. Release Date: 20120709. Correction Date: 20160613. Instrument Type: Rating Scale. Test Format: Each section of the scale contains a number of items with a scoring range of 0-6. The '0' end of the continuum denotes the hypothetically healthiest end of the adjustment range, and the '6' the hypothetically least healthy end.. Language: English. Constructs: Developmental Goal Achievement; Premorbid Adjustment; Schizophrenia Onset; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Premorbid Adjustment Scale is to evaluate the degree of achievement of developmental goals at each of several periods of a subject's life before the onset of schizophrenia.
AB  - Description: The Premorbid Adjustment Scale (PAS) was developed by Cannon-Spoor, Potkin, & Wyatt (1982). It is designed to evaluate the degree of achievement of developmental goals at each of several periods of a subject's life before the onset of schizophrenia. It evaluates the level of functioning in four major areas: social accessibility-isolation, peer relationships, ability to function outside the nuclear family, and capacity to form intimate socio-sexual ties. Items evaluating age-appropriate functioning in these areas are repeated for each period of the subject's life. The four life period sections are as follows: Childhood, up to 11 years; Early Adolescence, 12-15 years; Late Adolescence, 16-18 years; and Adulthood, 19 years and beyond. The final section, labeled General, is more global, containing items meant to estimate the highest level of functioning that the subject achieved before becoming ill, as well as the time span and characteristics of onset of illness, and general information such as amount of education. Scale items are made up of a combination of original, adopted, and modified items from the Phillips Scale, the Premorbid Social Adjustment Scale, and the Elgin Scale. Each section of the scale contains a number of items with a scoring range of 0-6. Psychometric properties of the scale were determined in several studies. The PAS appears to be useful in identifying patients likely to become chronically hospitalized or at high risk for readmission. It may also serve as a possible predictor of patients with brain abnormalities on a computerized tomography (CT) scan. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Premorbid Adjustment Scale
KW  - Schizophrenia
KW  - Functioning Level
KW  - Patient History
KW  - Test Development
KW  - Test Reliability
KW  - Test Validity
U5  - Premorbid Adjustment Scale (PAS) [Test Development]Measurement of premorbid adjustment in chronic schizophrenia. (AN: 1983-07993-001 from PsycINFO) Cannon-Spoor, H. Eleanor; Potkin, Steven G.; Wyatt, Richard J.; 1982. Source: Schizophrenia Bulletin. 8(3), National Institute of Mental Health, US; 1982; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Sample: Schizophrenic Patients; Normal Controls Keywords: Premorbid Adjustment Scale; Schizophrenia; Functioning Level; Patient History; Test Development; Test Reliability; Test Validity; Subjects: Ability Level; Adjustment; Patient History; Premorbidity; Schizophrenia; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t12929-000
L3  - Full; Full text; 999912929_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Wilson, Rickey
AU  - Anderson, Larry J.
AU  - Holman, Robert C.
AU  - Gary, G. William
AU  - Greenberg, Harry B.
T1  - Waterborne Gastroenteritis due to the Norwalk Agent: Clinical and Epidemiologic Investigation.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1982/01//
VL  - 72
IS  - 1
M3  - Article
SP  - 72
PB  - American Public Health Association
SN  - 00900036
AB  - An outbreak of gastroenteritis occurred at it Pennsylvania summer camp in July 1978. Symptoms included abdominal pail  (81 per cent), nausea (72 per cent), and vomiting (53 per cent): upper respiratory infection symptoms occurred in 35 per cent of the campers. Illness was associated with consumption of five or more glasses of water or water-containing beverages. Stool cultures from affected persons were negative for bacterial pathogens: however, a fourfold or greater rise to the Norwalk agent  was demonstrated in serum samples of three ill persons tested and in none of eight controls (p < .02). Campers ill during the first session who were also present during the second session did not become ill during the second second session (p < .001). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDEMIOLOGY -- Research
KW  - GASTROENTERITIS
KW  - PATHOGENIC microorganisms
KW  - CLINICAL medicine
KW  - THERAPEUTICS
KW  - DISEASES
KW  - PUBLIC health
KW  - HUMAN services
KW  - PREVENTIVE medicine
KW  - PENNSYLVANIA
N1  - Accession Number: 4949300; Wilson, Rickey 1 Anderson, Larry J. 2 Holman, Robert C. 2 Gary, G. William 3 Greenberg, Harry B. 4; Affiliation:  1: Department of Pediatrics, Texas Tech University, Regional Academic Health Sciences Center, 1400 Wallace Boulevard, Amarillo, TX 79106.  2: Viral Diseases Division, Bureau of Epidemiology, CDC.  3: Virology Division, Bureau of Laboratories, CDC.  4: National Institute of Allergy and Infectious Diseases, NIH, Bethesda.; Source Info: Jan1982, Vol. 72 Issue 1, p72; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: GASTROENTERITIS; Subject Term: PATHOGENIC microorganisms; Subject Term: CLINICAL medicine; Subject Term: THERAPEUTICS; Subject Term: DISEASES; Subject Term: PUBLIC health; Subject Term: HUMAN services; Subject Term: PREVENTIVE medicine; Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Barral-Netto, M.
AU  - Hofstetter, M.
AU  - Gustavo Dos Santos, J.
AU  - Cheever, A. W.
AU  - Ottesen, E. A.
T1  - Schistosoma mekongi infection in man: cellular immune responses and modulating mechanisms.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/01//
VL  - 47
IS  - 1
M3  - Article
SP  - 65
EP  - 73
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Cell-mediated immune responses (CMI), as assessed by lymphocyte proliferation in vitro. were evaluated in 11 Laotian patients harbouring asymptomatic chronic infections by Schistosoma mekongi, a schistosome closely related to S. japanicum. When the mononuclear cells of these patients were cultured in autologous plasma, lymphocyte responses to schistosome antigens were essentially nil, not differing from those of unexposed North American controls. Specific lymphocyte proliferation, however, was seen both after the removal of mononuclear cells that were nylon-wool-adherent and after substitution of the autologous serum in the culture with normal AB serum. Our data suggest that the CMI responses of humans with chronic S. mekongi infections are 'modulated' by adherent suppressor cells and serum-suppressive factors, and that modulation of CMI supports the stable host-parasite relationship in a similar fashion to that described for chronic human Schistosoma mansoni infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLULAR immunity
KW  - LYMPHOCYTES
KW  - BLOOD cells
KW  - IMMUNE response
KW  - SCHISTOSOMA
KW  - CELL proliferation
N1  - Accession Number: 16344827; Barral-Netto, M. 1 Hofstetter, M. 1 Gustavo Dos Santos, J. 2 Cheever, A. W. 1 Ottesen, E. A. 1; Affiliation:  1: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland.  2: Medical College of Virginia, Richmond, Virginia, USA.; Source Info: Jan1982, Vol. 47 Issue 1, p65; Subject Term: CELLULAR immunity; Subject Term: LYMPHOCYTES; Subject Term: BLOOD cells; Subject Term: IMMUNE response; Subject Term: SCHISTOSOMA; Subject Term: CELL proliferation; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Agrawala, Ashok K.
AU  - Tripathi, Satish K.
AU  - Ricart, Glenn
T1  - Adaptive Routing Using a Virtual Waiting Time Technique.
JO  - IEEE Transactions on Software Engineering
JF  - IEEE Transactions on Software Engineering
Y1  - 1982/01//
VL  - 8
IS  - 1
M3  - Article
SP  - 76
EP  - 81
SN  - 00985589
AB  - The virtual waiting time technique is introduced as a solution to the problem of a controller distributing work to servers of different speeds. The servers are considered to be part of a distributed system without feedback. The virtual waiting time technique is shown to minimize the average completion time for a job distributed by the controller. The virtual waiting time technique does not depend on any arrival distribution and is applicable to any service time distribution. The performance of the technique is examined for different arrival and service time distributions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of IEEE Transactions on Software Engineering is the property of IEEE Computer Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPUTER systems
KW  - DISTRIBUTED computing
KW  - COMPUTER networks
KW  - MULTIUSER computer systems
KW  - COMPUTERS
KW  - SOFTWARE engineering
KW  - Load sharing
KW  - routing
KW  - virtual waiting time
N1  - Accession Number: 14385881; Agrawala, Ashok K. 1 Tripathi, Satish K. 1 Ricart, Glenn 2; Affiliation:  1: Department of Computer Science, University of Maryland, College Park, MD  2: Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD; Source Info: Jan82, Vol. 8 Issue 1, p76; Subject Term: COMPUTER systems; Subject Term: DISTRIBUTED computing; Subject Term: COMPUTER networks; Subject Term: MULTIUSER computer systems; Subject Term: COMPUTERS; Subject Term: SOFTWARE engineering; Author-Supplied Keyword: Load sharing; Author-Supplied Keyword: routing; Author-Supplied Keyword: virtual waiting time; NAICS/Industry Codes: 541512 Computer Systems Design Services; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 334111 Electronic Computer Manufacturing; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443142 Electronics Stores; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); Number of Pages: 6p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weiss, N.
AU  - Hussain, R.
AU  - Ottesen, E. A.
T1  - IgE antibodies are more species-specific than IgG antibodies in human onchocerciasis and lymphatic filariasis.
JO  - Immunology
JF  - Immunology
Y1  - 1982/01//
VL  - 45
IS  - 1
M3  - Article
SP  - 129
EP  - 137
PB  - Wiley-Blackwell
SN  - 00192805
AB  - To explore the relative species specificities of the IgE and IgG antibody responses to helminth infections in man, we studied four pools of sera from patients infected with Wuchereria bancrofti, Brugia malayi, Onchocerca volvulus or Ascaris lumbricoides and ten individual sera from patients with onchocerciasis. IgE antibodies were detected by radioallergosorbent test (RAST) analysis and IgO antibodies by a Staphylococcus protein A radioimmunoassay (Staph A-RIA). Analysis of the binding curves with four different immunosorbents (prepared from antigens of B. malayi, O. volvulus, Dipesalonema viteae and A. lwnbricoides) in the RAST and the binding curves with these same four antigens in the Staph A-RIA confirmed the relative species specificities for both the IgE and IgO antibody responses. Then determination of these antibody levels after specific absorption of the sera with both homologous and heterologous antigens showed that in all instances there was significantly less cross-reactivity with heterologous parasite antigens (i.e. higher species specificity) in the IgE antibody. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - FILARIASIS
KW  - PATIENTS
KW  - ANTIGENS
KW  - SERUM
KW  - PARASITES
N1  - Accession Number: 14175752; Weiss, N. 1 Hussain, R. 1 Ottesen, E. A. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1982, Vol. 45 Issue 1, p129; Subject Term: IMMUNOGLOBULINS; Subject Term: FILARIASIS; Subject Term: PATIENTS; Subject Term: ANTIGENS; Subject Term: SERUM; Subject Term: PARASITES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rudorfer, Matthew V.
T1  - Cardiovascular Changes and Plasma Drug Levels after Amitriptyline Overdose.
JO  - Journal of Toxicology -- Clinical Toxicology
JF  - Journal of Toxicology -- Clinical Toxicology
Y1  - 1982/01//
VL  - 19
IS  - 1
M3  - Article
SP  - 67
EP  - 78
SN  - 07313810
N1  - Accession Number: 79032066; Rudorfer, Matthew V. 1,2; Affiliations: 1: Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, 63110; 2: Pharmacological Sciences Program, National Institute of General Medical Sciences; and Clinical Psychobiology Branch National Institute of Mental Health, Bethesda, Maryland, 20205; Issue Info: 1982, Vol. 19 Issue 1, p67; Number of Pages: 12p; Document Type: Article
L3  - 10.3109/15563658208990367
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Whitehead, William E.
AU  - Orr, William C.
AU  - Engel, Bernard T.
AU  - Schuster, Marvin M.
T1  - External Anal Sphincter Response to Rectal Distention: Learned Response or Reflex.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1982/01//
VL  - 19
IS  - 1
M3  - Article
SP  - 57
EP  - 62
SN  - 00485772
AB  - Three experiments were conducted to determine whether the external anal sphincter contraction which typically follows rectal distention is a reflex or a voluntary response. Experiment I compared 15 chronically constipated patients to 10 normal subjects. A reflex should be reliably elicited by its unconditional stimulus; but if this response is voluntary, chronically constipated patients would be less likely to show it because they have had fewer opportunities to practice it. Only half of chronically constipated patients showed the response compared to 100% of normals. Experiment II investigated whether the response is elicited by rectal distention during sleep in 10 healthy subjects. The response was significantly less likely to occur during sleep. Experiment III in 6 normal subjects revealed that this response can be voluntarily omitted. These experiments indicate that external anal sphincter contraction following rectal distention is a voluntary response, not a reflex. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - REFLEXES
KW  - SPHINCTERS
KW  - NEUROLOGIC examination
KW  - CONSTIPATION
KW  - DEFECATION disorders
KW  - APPLIED psychology
N1  - Accession Number: 14179992; Whitehead, William E. 1,2 Orr, William C. 3 Engel, Bernard T. 4,5 Schuster, Marvin M. 6; Affiliation:  1: Department of Psychiatry, Johns Hopkins University School of Medicine, Gerontology Research Center (Baltimore).  2: National Institute on Aging, National Institute of Health, Department of Human Health Services, Bethesda, Baltimore City Hospitals.  3: Department of Clinical Physiology, Presbyterian Hospital, Oklahoma City, Oklahoma.  4: Gerontology Research Center (Baltimore), National Institute on Aging, National Institute of Health, Department of Human Health Services, Bethesda.  5: Baltimore City Hospitals.  6: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore City Hospitals.; Source Info: Jan1982, Vol. 19 Issue 1, p57; Subject Term: REFLEXES; Subject Term: SPHINCTERS; Subject Term: NEUROLOGIC examination; Subject Term: CONSTIPATION; Subject Term: DEFECATION disorders; Subject Term: APPLIED psychology; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2009-11812-001
AN  - 2009-11812-001
AU  - Brunstetter, Richard
T1  - Preface.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1982///
VL  - 8
IS  - 2
SP  - 199
EP  - 200
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-11812-001. Partial author list: First Author & Affiliation: Brunstetter, Richard; Center for Studies of Child and Adolescent Psychopathology, Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychopathology; Child Psychopathology; Schizophrenia. Minor Descriptor: Mental Health. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Page Count: 2. Issue Publication Date: 1982. 
AB  - The appearance of this issue of the Schizophrenia Bulletin marks an important phase in the development of the field of research in child and adolescent psychopathology. In its preparation, the Center for Studies of Schizophrenia has been joined by the Center for Studies of Child and Adolescent Psychopathology, which has recently been established in the Clinical Research Branch of the Division of Extramural Research Programs at the National Institute of Mental Health. Furthermore, this is the first time that an entire issue has been devoted to children and adolescents. From time to time over the years, important articles in this area for instance DeMyer, Hingtgen, and Jackson's review article on infantile autism (Vol. 7, No. 3, 1981) have appeared, but never before has the sense of growth in the field been such that it seemed warranted to devote a complete issue to what was happening in it. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - child psychopathology
KW  - adolescent psychopathology
KW  - 1982
KW  - Adolescent Psychopathology
KW  - Child Psychopathology
KW  - Schizophrenia
KW  - Mental Health
KW  - 1982
DO  - 10.1093/schbul/8.2.199
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Helmes, C. T.
AU  - Atkinson, D. L.
AU  - Jaffer, J.
AU  - Sigman, C. C.
AU  - Thompson, K. L.
AU  - Kelsey, M. I.
AU  - Kraybill, H. F.
AU  - Munn, J. I.
T1  - Evaluation and classification of the potential carcinogenicity of organic air pollutants*.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/03/
VL  - 17
IS  - 3
M3  - Article
SP  - 321
EP  - 389
SN  - 03601226
AB  - Data on the carcinogenicity and Ames Salmonella test muta‐genicity were compiled for 671 organic chemicals reported to be potential air pollutants. Development of the data base entailed an evaluation of published reports of carcinogenicity and mutagenicity test results available in the open literature. Criteria were established for classifying the chemicals as recognized carcinogens, suspected carcinogens, tumor promoters or cocarcinogens, and mutagens or suspected mutagens. Confirmation of chemicals as ambient air pollutants was attempted only for the chemicals classified into a category of potential carcinogenicity other than unknown. Primary and secondary literature sources were searched for the reported detection of the chemicals as ambient air pollutants. This work resulted in the classification of 77 air pollutants as potential human carcinogens, as demonstrated by the categorization of 25 air pollutants as recognized carcinogens, 20 air pollutants as suspected carcinogens, 15 air pollutants as tumor promoters/cocarcinogens, and 50 air pollutants as mutagens or suspected mutagens. For 17 of the 50 air pollutants classified as mutagens or suspected mutagens, no adequate positive carcino‐genicity data were found. No evidence of mutagenicity determined by the Ames test was found for seven of the 25 recognized carcinogens or for nine of the 20 suspected carcinogens. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490486; Helmes, C. T. 1 Atkinson, D. L. 1 Jaffer, J. 1 Sigman, C. C. 1 Thompson, K. L. 1 Kelsey, M. I. 2 Kraybill, H. F. 2 Munn, J. I. 2; Affiliation:  1: SRI International, Menlo Park, CA, 94025  2: National Cancer Institute, Bethesda, MD, 20014; Source Info: Jan1982, Vol. 17 Issue 3, p321; Number of Pages: 69p; Document Type: Article
L3  - 10.1080/10934528209375038
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rogan, Walter
T1  - Exposure‐epidemiology: Novel approaches.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/04/
VL  - 17
IS  - 4
M3  - Article
SP  - 457
EP  - 461
SN  - 03601226
AB  - The proliferation of potentially toxic agents in the environment has caused suspicion that cancer, heart, lung, and other diseases will be produced. Epidemiologists seek associations between such agents and diseases with prevention in mind. Efficient use of established techniques of study and innovative new ones will be necessary for prevention to be achieved before obvious morbidity and mortality have taken place. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490493; Rogan, Walter 1; Affiliation:  1: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709; Source Info: Jan1982, Vol. 17 Issue 4, p457; Number of Pages: 5p; Document Type: Article
L3  - 10.1080/10934528209375045
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hayes, Howard M.
AU  - Mason, Thomas J.
T1  - Some domesticated animals as sentinels of human disease.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/04/
VL  - 17
IS  - 4
M3  - Article
SP  - 477
EP  - 485
SN  - 03601226
AB  - The past use of animal models to denote hazards in man's environment is reviewed. Examples are presented of selected species with respect to their response to exposures from certain bacteria, viruses, parasites, mineral deficiencies, plant toxins, and man‐made substances analogous to the human experience. The importance of continued research in this field is emphasized in order to provide a clearer understanding of the effects of the ambient environment on present and subsequent human health. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490496; Hayes, Howard M. 1 Mason, Thomas J. 1; Affiliation:  1: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p477; Number of Pages: 9p; Document Type: Article
L3  - 10.1080/10934528209375048
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kraybill, Herman F.
T1  - Multimedia exposure and concerns for a holistic approach toward assessment of risk for environmental carcinogens.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/04/
VL  - 17
IS  - 4
M3  - Article
SP  - 491
EP  - 497
SN  - 03601226
AB  - The necessity of studying man's interaction with his environment through multiple exposures to toxic agents is discussed in terms of a holistic approach to the study of environmental cancer. Six factors that should be considered in the elucidation of exposure/response relationships and risk analysis are set forth. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490498; Kraybill, Herman F. 1; Affiliation:  1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p491; Number of Pages: 7p; Document Type: Article
L3  - 10.1080/10934528209375050
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lingeman, Carolyn H.
T1  - Human resources—measurement of environmental contaminants in post mortem sampling.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/04/
VL  - 17
IS  - 4
M3  - Article
SP  - 515
EP  - 518
SN  - 03601226
AB  - To properly evaluate the etiologic roles of environmental chemicals in chronic diseases such as cancer, arteriosclerosis, and fibrosing lung diseases, there is a need for an Environmental Tissue Pathology Repository with facilities for correlating environmental histories, pathologic lesions in tissues and levels of chemicals or particulate matter. The Armed Forces Institute of Pathology (AFIP) would be an appropriate location for such a facility. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490500; Lingeman, Carolyn H. 1,2; Affiliation:  1: National Cancer Institute, Bethesda, MD, 20205  2: The Armed Forces Institute of Pathology, Washington, D.C., 20306; Source Info: Jan1982, Vol. 17 Issue 4, p515; Number of Pages: 4p; Document Type: Article
L3  - 10.1080/10934528209375052
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gillette, James R.
T1  - Problems in risk assessment.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/04/
VL  - 17
IS  - 4
M3  - Article
SP  - 553
EP  - 558
SN  - 03601226
AB  - Most quantitative risk assessments are based on the assumption that environmental chemicals cause the same toxicities in humans and laboratory animals in about the same concentrations. It is well known, however, that the assumption is invalid in most instances. What is needed is the development of a program of interrelated studies designed to elucidate active forms of the toxicant, the concentrations at which these forms cause the observed toxicities in different species and strains of animals and the factors that modify the manifestation and severity of the toxicities. Such knowledge should provide key clues for identifying sensitive human subpopulations. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490505; Gillette, James R. 1; Affiliation:  1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p553; Number of Pages: 6p; Document Type: Article
L3  - 10.1080/10934528209375057
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nebert, Daniel W.
T1  - The importance of genetics in the metabolism and fate of mutagens and promutagens.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1982/01/04/
VL  - 17
IS  - 4
M3  - Article
SP  - 559
EP  - 566
SN  - 03601226
AB  - Because of differences in gene expression and variability among the various test systems, extrapolation of mutagenesis data gained from nonhuman studies to predictability of mutagens in man is shown to be very difficult. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490506; Nebert, Daniel W. 1; Affiliation:  1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p559; Number of Pages: 8p; Document Type: Article
L3  - 10.1080/10934528209375058
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chae, Kun
AU  - Albro, Phillip W.
AU  - McKinney, James D.
T1  - A new synthesis of tetrachlorofluorodibenzo‐ p ‐dioxin.
JO  - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF  - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1  - 1982/01/05/
VL  - 17
IS  - 5
M3  - Article
SP  - 441
EP  - 445
SN  - 03601234
AB  - The 1,2,3,4‐tetrachloro‐7‐fluorodibenzo‐p‐dioxin has been synthesized via condensation of 4‐fluorocatechol and pentachloronitrobenzene. This compound could be used as an internal standard for the analysis of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin by Chromatographic methods. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75452674; Chae, Kun 1; Albro, Phillip W. 1; McKinney, James D. 1; Affiliations: 1: Laboratory of Environmental Chemistry, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, 27709; Issue Info: Jan1982, Vol. 17 Issue 5, p441; Number of Pages: 5p; Document Type: Article
L3  - 10.1080/03601238209372333
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Albro, Phillip W.
AU  - Hass, J. Ronald
AU  - Peck, Carl C.
AU  - Jordan, Sandra T.
AU  - Corbett, Jean T.
AU  - Schroeder, Joanna
T1  - Applications of isotope differentiation for metabolic studies with di‐(2‐ethylhexyl) phthalate.
JO  - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF  - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1  - 1982/01/06/
VL  - 17
IS  - 6
M3  - Article
SP  - 701
EP  - 714
SN  - 03601234
AB  - The pervasiveness of the plasticizer di‐(2‐ethylhexyl) phthalate (DEHP) in the environment and especially in the laboratory results in a background that may cause severe interference with analytical studies. Animal‐to‐animal variability in the distribution of DEHP metabolites in excreta normally makes it necessary to use large groups of animals when different treatments are compared. Finally, radioactive tracers are usually considered undesirable for metabolic studies involving human subjects. All of these problems can be overcome through the use of muliple isotopic labels, especially 12C/13C/14C. Examples are given involving rats and monkeys, and applicability to humans is discussed. The principles involved are not limited to any particular class of test compounds. In rats, the competing pathways for metabolism of phthalate esters produce a different distribution of metabolites from a small intravenous dose of DEHP than from a large oral dose. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75452708; Albro, Phillip W. 1; Hass, J. Ronald 1; Peck, Carl C. 2; Jordan, Sandra T. 1; Corbett, Jean T. 1; Schroeder, Joanna 1; Affiliations: 1: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, 27709; 2: Uniformed Services, University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, 20014; Issue Info: Jan1982, Vol. 17 Issue 6, p701; Number of Pages: 14p; Document Type: Article
L3  - 10.1080/03601238209372351
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WHANG-PENG, J.
AU  - KAO-SHAN, C. S.
AU  - LEE, E. C.
AU  - BUNN, P. A.
AU  - CARNEY, D. N.
AU  - GAZDAR, A. F.
AU  - MINNA, J. D.
T1  - Specific Chromosome Defect Associated with Human Small-Cell Lung Cancer: Deletion 3p(14-23).
JO  - Science
JF  - Science
Y1  - 1982/01/08/
VL  - 215
IS  - 4529
M3  - Article
SP  - 181
EP  - 182
SN  - 00368075
AB  - A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84704900; WHANG-PENG, J. 1; KAO-SHAN, C. S. 1; LEE, E. C. 1; BUNN, P. A. 2; CARNEY, D. N. 2; GAZDAR, A. F. 2; MINNA, J. D. 2; Affiliations: 1: Medicine Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: NCI-VA Medical Oncology Branch, Division of Cancer Treatment, National Cancer Institute, and Washington VA Medical Center, Washington, D.C. 20422; Issue Info: 1/ 8/1982, Vol. 215 Issue 4529, p181; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - MEYER, D. K.
AU  - BEINFELD, M. C.
AU  - OERTEL, W. H.
AU  - BROWNSTEIN, M. J.
T1  - Origin of the Cholecystokinin-Containing Fibers in the Rat Caudatoputamen.
JO  - Science
JF  - Science
Y1  - 1982/01/08/
VL  - 215
IS  - 4529
M3  - Article
SP  - 187
EP  - 188
SN  - 00368075
AB  - Large amounts of cholecystokinin-octapeptide (CCK) are present in the rat caudatoputamen. The peptide occurs in axons and nerve endings but not in perikarya. The origin of CCK in the caudatoputamen was investigated with the use of immunocytochemistry and a radioimmunoassay specific for CCK. Although a small amount of CCK (approximately 30 percent) originates in the amygdaloid complex, the bulk of the peptide (approximately 70 percent) occurs in processes of neurons located ventral to the caudatoputamen, that is, the claustrum or the piriform cortex. The claustrum and piriform cortex receive inputs from various cortical areas and the olfactory system, respectively, and may process information and relay it to the caudatoputamen. Thus CCK may be the transmitter in the final common pathway linking various cortical areas and the olfactory system to the caudatoputamen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84704903; MEYER, D. K. 1; BEINFELD, M. C. 1; OERTEL, W. H. 1; BROWNSTEIN, M. J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 1/ 8/1982, Vol. 215 Issue 4529, p187; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Lenk, Robert P.
AU  - Maizel Jr., Jacob V.
AU  - Crouch, Robert J.
T1  - Expression of Two Late Adenovirus Genes Is Altered by Introducing Antibodies against Ribonucleoprotein into Living HeLa Cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1982/01/15/
VL  - 121
IS  - 3
M3  - Article
SP  - 475
EP  - 482
PB  - Wiley-Blackwell
SN  - 00142956
AB  - These experiments describe the effect on adenovirus gene expression of transfusing liposome-encapsulated antibodies directed against a 10-S ribonucleoprotein complex into infected Hela cells. Immunoprecipitation studies demonstrate that this particular serum contains antibodies directed against particles containing U 1 RNA and five polypeptides in the molecular weight range of 45000-60000. The procedure of fusing liposomes successfully treats nearly all the cells in culture, and the transfused material has access throughout the cell. The IgG fraction from this serum is introduced into adenovirus-infected cells shortly before the transition from the early to the fate stage of the lytic cycle; 19 h after fusion the accumulated effects of the antibodies on late virus expression are examined by pulse-labeling cells with radioactive methionine and observing the synthesized proteins. While most late viral genes are expressed normally in treated cells, fiber synthesis is reduced to a very low level and hexon synthesis is reduced twofold. That most viral genes are expressed normally demonstrates that many cell activities (transcription, transport, processing and translation) are minimally affected. The effects on these two genes can be distinguished by varying the concentration of antibody transfused: interference with hexon synthesis occurs at a lower dosage than fiber. A simple interpretation of these results is that the antibody has bound to its antigen and prevented the latter from participating in its role in message processing. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE expression
KW  - CELLS
KW  - IMMUNOGLOBULINS
KW  - BLOOD plasma
KW  - CLONE cells
KW  - NUCLEIC acids
KW  - HEREDITY
N1  - Accession Number: 15800496; Lenk, Robert P. 1 Maizel Jr., Jacob V. 1 Crouch, Robert J. 1; Affiliation:  1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 1/15/82, Vol. 121 Issue 3, p475; Subject Term: GENE expression; Subject Term: CELLS; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD plasma; Subject Term: CLONE cells; Subject Term: NUCLEIC acids; Subject Term: HEREDITY; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Milne, G. W. A.
AU  - Fisk, C. L.
AU  - Heller, Stephen R.
AU  - Potenzone Jr., Rudolph
T1  - Environmental Uses of the NIHEPA Chemical Information System.
JO  - Science
JF  - Science
Y1  - 1982/01/22/
VL  - 215
IS  - 4531
M3  - Article
SP  - 371
EP  - 375
SN  - 00368075
N1  - Accession Number: 88003537; Milne, G. W. A. 1; Fisk, C. L. 2; Heller, Stephen R. 3; Potenzone Jr., Rudolph 4; Affiliations: 1: Research chemist, National Cancer Institute, Bethesda, Maryland 20205; 2: Staff fellow, National Institutes of Health, Bethesda, Maryland 20205; 3: Physical scientist, Management Information Data Systems Division, Environmental Protection Agency, Washington, D.C. 20460; 4: Systems analyst, Management Information Data Systems Division, Environmental Protection Agency, Washington, D.C. 20460; Issue Info: 1/22/1982, Vol. 215 Issue 4531, p371; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Patrick, Clifford H.
AU  - Palesch, Yuko Y.
AU  - Feinleib, Manning
AU  - Brody, Jacob A.
T1  - Sex Differences in Declining Cohort Death Rates From Heart Disease.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1982/02//
VL  - 72
IS  - 2
M3  - Article
SP  - 161
PB  - American Public Health Association
SN  - 00900036
AB  - We examined cohort mortality from heart disease (HD) at ages 40 and over for White men and women in the United States between 1945 and 1975. For each successive birth cohort from 1886 to 1890 and 1906 to 1910, female HD mortality rates exhibit a continuous decline with parallel slopes which shows no sign of abating in recent years. Among men, cohort HD mortality rates were increasing prior to 1965: since 1965, there has been a reversal of prior trends, i.e., each successive cohort has shown a decrease in HD mortality rates. None of the various hypotheses put forward to explain the recent decline in HD mortality provides a cogent explanation for the differential effects in men and women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEART diseases
KW  - DEATH
KW  - MORTALITY
KW  - WOMEN -- Health
KW  - DEMOGRAPHY
KW  - SOCIAL indicators
KW  - GENDER
KW  - HYPOTHESIS
KW  - MEN -- United States
N1  - Accession Number: 4950997; Patrick, Clifford H. 1 Palesch, Yuko Y. 2 Feinleib, Manning 3 Brody, Jacob A. 4; Affiliation:  1: Office of Research and Statistics, SSA, National Institute of Health  2: Epilepsy Branch, Neurological Disorders Program, NHLBI, National Institute of Health  3: Epidemiology and Biometry Program, Division of Heart and Vascular Diseases, NHLBI, National Institute of Health  4: Epidemiology, Demography, and Biometry Program, National institute on Aging, Federal Building, Room 612, Bethesda, MD 20205; Source Info: Feb1982, Vol. 72 Issue 2, p161; Subject Term: HEART diseases; Subject Term: DEATH; Subject Term: MORTALITY; Subject Term: WOMEN -- Health; Subject Term: DEMOGRAPHY; Subject Term: SOCIAL indicators; Subject Term: GENDER; Subject Term: HYPOTHESIS; Subject Term: MEN -- United States; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yanagihara, R.H.
AU  - Adler, W.H.
T1  - Inhibition of mouse natural killer activity by cyclosporin A.
JO  - Immunology
JF  - Immunology
Y1  - 1982/02//
VL  - 45
IS  - 2
M3  - Article
SP  - 325
EP  - 332
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Cyclosporin A (CSA), administered in vivo or in vitro, inhibited the spontaneous cytotoxicity of C57BL/6 and NZB/WF1 mouse spleen cells against YAC and K562 target cells in a 4 hr 51Crk release assay. Inhibition of natural killing (NK) by CSA occurred rapidly, was dose-dependent, and did not require the presence of T cells, B cells or macrophages. CSA depressed NK activity by direct interaction with NK cells. There was no evidence that inhibition of NK by CSA was mediated through suppressor cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KILLER cells
KW  - CYCLOSPORINE
KW  - T cells
KW  - B cells
KW  - CELL interaction (Biology)
KW  - SUPPRESSOR cells
N1  - Accession Number: 13950244; Yanagihara, R.H. 1 Adler, W.H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, U.S.A.; Source Info: Feb82, Vol. 45 Issue 2, p325; Subject Term: KILLER cells; Subject Term: CYCLOSPORINE; Subject Term: T cells; Subject Term: B cells; Subject Term: CELL interaction (Biology); Subject Term: SUPPRESSOR cells; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06541-002
AN  - 2006-06541-002
AU  - Shah, Saleem A.
T1  - Ethical Issues for Psychologists in the Criminal Justice System.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1982/02//
VL  - 27
IS  - 2
SP  - 87
EP  - 88
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06541-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; Center for Studies of Crime and Delinquency, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Criminal Behavior; Criminal Justice; Ethics; Forensic Psychology. Classification: Criminal Law & Adjudication (4230). Population: Human (10). Reviewed Item: Monahan, John (Ed). Who is the Client? The Ethics of Psychological Intervention in the Criminal Justice System=Washington, D.C.: American Psychological Association, 1980. 174 pp. $7.50 paper; 1980. Page Count: 2. Issue Publication Date: Feb, 1982. 
AB  - Reviews the book, Who is the Client? The Ethics of Psychological Intervention in the Criminal Justice System by John Monahan (Ed.) (see record [rid]1982-06341-000[/rid]). This book is the complete report of the APA Task Force on the Role of Psychology in the Criminal Justice System. The purpose of the Task Force, chaired by Monahan, was 'to investigate comprehensively the complex ways in which psychologists are involved in the criminal justice system and the ethical issues raised by this involvement'. The report attempts to isolate the key ethical issues for psychologists in criminal justice work and provides recommendations on the ethical course that psychology, as a profession, should set in this area. As in most compilations the contributions vary somewhat in their quality, but all are informative, thoughtfully done, and useful. In conclusion, the book is an informative and important report and one that should be used widely. It would be an excellent item for the long-needed graduate courses in applied ethics and related concerns in psychological practice and research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - criminal justice system
KW  - ethical issues
KW  - psychologists
KW  - clients
KW  - 1982
KW  - Criminal Behavior
KW  - Criminal Justice
KW  - Ethics
KW  - Forensic Psychology
KW  - 1982
U2  - Monahan, John (Ed). (1980); Who is the Client? The Ethics of Psychological Intervention in the Criminal Justice System; Washington, D.C.: American Psychological Association, 1980. 174 pp. $7.50 paper
DO  - 10.1037/020987
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06541-043
AN  - 2006-06541-043
AU  - Susman, Elizabeth J.
T1  - Surviving Childhood Cancer: Social and Psychological Stresses for Children and Families.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1982/02//
VL  - 27
IS  - 2
SP  - 133
EP  - 134
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06541-043. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Susman, Elizabeth J.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151207. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Emotional Adjustment; Neoplasms; Survivors. Minor Descriptor: Psychosocial Factors; Consequence. Classification: Cancer (3293). Reviewed Item: Koocher, Gerald P.; O'Malley, John E. The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer=New York: McGraw-Hill, 1981. 239 pp. $17.95; 1981. Page Count: 2. Issue Publication Date: Feb, 1982. 
AB  - Reviews the book, The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer by Gerald P. Koocher and John E. O'Malley (1981). The Damocles Syndrome is a historical precedent from two perspectives. First, only now in the history of treatment of childhood cancer could the authors have amassed a significantly large group of survivors to be the focus of scientific inquiry. Second, the book presents findings from one of the largest studies of psychosocial aspects of childhood cancer yet to be undertaken. As the title implies, it is the potential for long-term survival that is at the heart of the survivor's dilemma. The purpose of the book is to present the findings of an empirical study of the psychological vulnerabilities and invulnerabilities of having survived cancer in both the victims and their families. Ultimately, the book will prove to be of great benefit to both researchers and clinicians. In summary, the book is a needed and valuable resource for understanding this highly stressful and emotionally charged aspect of human experience. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - surviving childhood cancer
KW  - Damocles Syndrome
KW  - psychosocial consequences
KW  - history
KW  - treatment
KW  - 1982
KW  - Childhood Development
KW  - Emotional Adjustment
KW  - Neoplasms
KW  - Survivors
KW  - Psychosocial Factors
KW  - Consequence
KW  - 1982
U2  - Koocher, Gerald P.; O'Malley, John E. (1981); The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer; New York: McGraw-Hill, 1981. 239 pp. $17.95
DO  - 10.1037/020947
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06541-053
AN  - 2006-06541-053
AU  - Zahn, Theodore P.
T1  - A Perspective on Schizophrenia.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1982/02//
VL  - 27
IS  - 2
SP  - 146
EP  - 147
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06541-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Biopsychosocial Approach; Schizophrenia. Minor Descriptor: Phenomenology. Classification: Schizophrenia & Psychotic States (3213). Reviewed Item: Crider, Andrew. Schizophrenia: A Biopsychological Perspective=Hillsdale, N.J.: Erlbaum, 1979. 214 pp. $16.50; 1979. Page Count: 2. Issue Publication Date: Feb, 1982. 
AB  - Reviews the book, Schizophrenia: A Biopsychological Perspective by Andrew Crider (1979). The purpose of this book is 'to organize and to evaluate current concepts and findings...with a view toward the integrative possibilities they suggest'. The book presents views of various aspects of schizophrenia that most likely represented the consensus of students of this disorder about 1978. The volume's general flavor is captured by its goal to try 'to tell one story rather than many'. The book focuses on a few of the seminal research reports, reviews, or books as source material. The results of this paring is a clear, readable presentation of the most influential ideas and research findings. As far as the basic nature of schizophrenia is concerned, Crider relies almost exclusively on phenomenology as a data base. In conclusion, this book presents a better-than-adequate introduction to current concepts of schizophrenia for those in patient-care roles. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - biopsychological perspective
KW  - patient-care roles
KW  - phenomenology
KW  - 1982
KW  - Biopsychosocial Approach
KW  - Schizophrenia
KW  - Phenomenology
KW  - 1982
U2  - Crider, Andrew. (1979); Schizophrenia: A Biopsychological Perspective; Hillsdale, N.J.: Erlbaum, 1979. 214 pp. $16.50
DO  - 10.1037/020957
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06541-056
AN  - 2006-06541-056
AU  - Levitsky, David A.
AU  - Strupp, Barbara J.
T1  - Reinforcing Health Care.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1982/02//
VL  - 27
IS  - 2
SP  - 149
EP  - 150
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06541-056. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Levitsky, David A.; Division of Nutritional Sciences, Department of Psychology, Cornell University, Ithaca, NY, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Media. Language: English. Major Descriptor: Diets; Health Care Services; Nutrition; Nutritional Deficiencies. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Reviewed Item: Guthrie, George M.; Guthrie, Helen A. Preventing Malnutrition by Reinforcing Improved Diets=(Distributor Audio Visual Services, Pennsylvania State University, University Park, Pa, 16802) Sound and color, 28 minutes. $385.00 (16 mm.), $250.00 (video), $18.50 (16 mm rental); No Year Specified. Page Count: 2. Issue Publication Date: Feb, 1982. 
AB  - Reviews the film, Preventing Malnutrition by Reinforcing Improved Diets by George M. Guthrie and Helen A. Guthrie. The intention of this film produced by George and Helen Guthrie is to describe a field experiment in a rural community in the Philippines. The hypothesis is not only interesting, but also extremely important to millions of poor people living in poverty, disease, and malnutrition. The Guthries well understand the complexity involved in solving the problem of malnutrition. At first glance, the conclusion appears almost inhumane and conflicts with our idealistic concept of 'motherly love,' but on closer scrutiny it seems consistent with much of what we know about health care. However, the greatest flaw in the film as a medium for stimulating college audiences is its apparent superficiality. The apparent lack of depth in the film, which concerns a subject matter and an idea as profound as the use of reinforcement to eliminate malnutrition, makes this film best suited as a stimulus for discussion at an advanced level in psychology, anthropology, sociology, or nutrition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - health care
KW  - preventing malnutrition
KW  - improved diets
KW  - 1982
KW  - Diets
KW  - Health Care Services
KW  - Nutrition
KW  - Nutritional Deficiencies
KW  - 1982
U2  - Guthrie, George M.; Guthrie, Helen A. (No Year Specified); Preventing Malnutrition by Reinforcing Improved Diets; (Distributor Audio Visual Services, Pennsylvania State University, University Park, Pa, 16802) Sound and color, 28 minutes. $385.00 (16 mm.), $250.00 (video), $18.50 (16 mm rental)
DO  - 10.1037/020960
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - MARTIN, SAMUEL P.
AU  - SINGER, MAXINE
T1  - Confronting Creationism.
JO  - Science
JF  - Science
Y1  - 1982/02/05/
VL  - 215
IS  - 4533
M3  - Article
SP  - 612
EP  - 612
SN  - 00368075
N1  - Accession Number: 84704952; MARTIN, SAMUEL P. 1; SINGER, MAXINE 2; Affiliations: 1: Department of Anthropology, University of Illinois, Chicago Circle Campus, Chicago 60680; 2: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 2/ 5/1982, Vol. 215 Issue 4533, p612; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Stetten Jr., DeWitt
T1  - Philip Handler: An Appreciation (13 August 1917-29 December 1981).
JO  - Science
JF  - Science
Y1  - 1982/02/05/
VL  - 215
IS  - 4533
M3  - Article
SP  - 633
EP  - 634
SN  - 00368075
N1  - Accession Number: 84704959; Stetten Jr., DeWitt 1; Affiliations: 1: Senior Scientific Advisor, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/ 5/1982, Vol. 215 Issue 4533, p633; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ALKON, DANIEL L.
AU  - LEDERHENDLER, IZJA
AU  - SHOUKIMAS, JONATHAN J.
T1  - Primary Changes of Membrane Currents During Retention of Associative Learning.
JO  - Science
JF  - Science
Y1  - 1982/02/05/
VL  - 215
IS  - 4533
M3  - Article
SP  - 693
EP  - 695
SN  - 00368075
AB  - A single identified neuron was repeatedly isolated by axotomy from the central nervous system of the nudibranch mollusk Hermissenda crassicornis. An early voltage-dependent outward K+ current of this neuron was reduced and more rapidly inactivated for animals previously trained with paired but not randomized light and rotation. Since this current change can affect interneuron and motorneuron output via known synaptic pathways, it helps explain a long-lasting behavioral change that shows the defining features of vertebrate associative learning. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84705005; ALKON, DANIEL L. 1; LEDERHENDLER, IZJA 1; SHOUKIMAS, JONATHAN J. 1; Affiliations: 1: Section on Neural Systems, Laboratory of Biophysics, National Institutes of Health, Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 2/ 5/1982, Vol. 215 Issue 4533, p693; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Yuan-Tsong Chen
AU  - Lang, Matti A.
AU  - Jensen, Nancy M.
AU  - Negishi, Masahiko
AU  - Tukey, Robert H.
AU  - Sidransky, Ellen
AU  - Guenther, Thomas M.
AU  - Nebert, Daniel W.
T1  - Similarities between Mouse and Rat-Liver Microsomal Cytochromes P-450 Induced by 3-Methylanthrene.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1982/02/15/
VL  - 122
IS  - 2
M3  - Article
SP  - 361
EP  - 368
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Anti-(P1-450) and anti-(P-448) are two antibodies developed against distinctly different Forms of 3-methyl- cholanthrene-induced cytochrome P-450 in C57BL/6N mouse liver microsomes [Negishi and Nebert, J. Blot C/win. 254, 11015-11023 (1979)]. The effects of these antibodies on long-Evans and Sprague-Dawley rat liver microsomes and rat `minimal deviation' hepatoma 7777 microsomes were studied. Rat microsomal aryl hydrocarbon hydroxylase activity, induced by polycyclic aromatic compounds, is preferentially inhibited by anti-(Pi-450) more so than anti-(P-448). Polycyclic-aromatic-induced rat liver microsomal acetanilide 4-hydroxylase activity is preferentially inhibited by anti-(P-448) more so than anti-(P,-450). Anti (P1 -450) precipitates a 56-kDa moiety in polycyclic aromatic-induced rat liver microsomes. Anti-(P-448) precipitates a 55-kDa moiety in control, phenobarbital-treated, or polycyclic-aromatic-induced rat liver microsomes. A heterogeneity was found amongst individual Morris `minimal deviation' hepatomas 7777. indicating the 3-metliylcholanthrene-induced aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase activities must represent different forms of rat P1-450. Clone 46 DNA, a portion of the mouse cloned P1-450 structural gene. hybridizes to one gene (or a small number of genes) in rat liver and to 3-niethylcholanthrene-induced rat 23-S P1-450 mRNA. As has already been shown in the mouse [Tukey, Nebert and Negishi, J. Biol. Chem. 256, 6969-6974 (1981)], rat liver P1-450 induction is under transcriptional control, and there is no evidence for gene amplification or some gross form of DNA rearrangement. These data demonstrate striking similarities between rat and mouse for the P1-450 structural gene, the P1-450 mRNA, the P1-450 protein and the P-448 protein. Polycyclic-aronlatic-induced P1-450, and its association with polycyclic-aromatic-induced aryl hydrocarbon hydroxylase activity, therefore does not appear to be closely correlated with polycyclic-aromatic-induced P-448 in either rat or mouse. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIVER cells
KW  - MICROSOMES
KW  - CYTOCHROME P-450
KW  - PROTOPLASM
KW  - BILIARY tract
KW  - ORGANIC compounds
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 13827854; Yuan-Tsong Chen 1,2,3 Lang, Matti A. 1,2,3 Jensen, Nancy M. 1,2,3 Negishi, Masahiko 1,2,3 Tukey, Robert H. 1,2,3 Sidransky, Ellen 1,2,3 Guenther, Thomas M. 1,2,3 Nebert, Daniel W. 1,2,3; Affiliation:  1: Developmental Pharmacology Branch.  2: National Institute of Child Health and Human Development.  3: National Institutes of Health, Bethesda, Maryland; Source Info: 2/15/82, Vol. 122 Issue 2, p361; Subject Term: LIVER cells; Subject Term: MICROSOMES; Subject Term: CYTOCHROME P-450; Subject Term: PROTOPLASM; Subject Term: BILIARY tract; Subject Term: ORGANIC compounds; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MELNICK, VIJAYA L.
AU  - DEAN, DONALD S.
T1  - Alzheimer's Disease: Research Guidelines.
JO  - Science
JF  - Science
Y1  - 1982/02/19/
VL  - 215
IS  - 4535
M3  - Article
SP  - 913
EP  - 914
SN  - 00368075
N1  - Accession Number: 88003610; MELNICK, VIJAYA L. 1; DEAN, DONALD S. 2; Affiliations: 1: National Institute on Aging, Bethesda, Maryland 20205; 2: Biology Department, Baldwin-Wallace College, Berea, Ohio 44017; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p913; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROBERT-GUROFF, MARJORIE
AU  - NAKAO, YOSHINOBU
AU  - NOTAKE, KUNIHIRO
AU  - ITO, YOHEI
AU  - SLISKI, ANN
AU  - GALLO, ROBERT C.
T1  - Natural Antibodies to Human Retrovirus HTLV in a Cluster of Japanese Patients with Adult T Cell Leukemia.
JO  - Science
JF  - Science
Y1  - 1982/02/19/
VL  - 215
IS  - 4535
M3  - Article
SP  - 975
EP  - 978
SN  - 00368075
AB  - Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from afew patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy including Japanese adult T cell leukemia. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003649; ROBERT-GUROFF, MARJORIE 1; NAKAO, YOSHINOBU 2; NOTAKE, KUNIHIRO 3; ITO, YOHEI 4; SLISKI, ANN 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Kobe University School of Medicine, Department of Medicine, Kobe, Japan; 3: Aichi Medical University, Department of Microbiology, Nagoya, Japan; 4: Kyoto University Faculty of Medicine, Department of Microbiology, Kyoto, Japan; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p975; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LOUMAYE, ERNEST
AU  - CATT, KEVIN J.
T1  - Homologous Regulation of Gonadotropin-Releasing Hormone Receptors in Cultured Pituitary Cells.
JO  - Science
JF  - Science
Y1  - 1982/02/19/
VL  - 215
IS  - 4535
M3  - Article
SP  - 983
EP  - 985
SN  - 00368075
AB  - Specific receptors for gonadotropin-releasing hormone (GnRH) in cultured rat pituitary cells were increased by subnanomolar concentrations of GnRH agonists and decreased by high concentrations of these peptides. The antagonist [DPhe², Pro³,D-Phe6]GnRH did not alter GnRH binding capacity and blocked the increase in sites induced by GnRH. These findings provide direct evidence for the homologous regulation of GnRH receptors by physiological concentrations of the hypothalamic peptide, an action that could mediate the cyclical and postcastration increases in GnRH receptors and responsiveness of the pituitary gonadotrophs. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003652; LOUMAYE, ERNEST 1; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p983; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KING, CHARLES R.
AU  - SHINOHARA, TOSHIMICHI
AU  - PIATIGORSKY, JORAM
T1  - αA-Crystallin Messenger RNA of the Mouse Lens: More Noncoding Than Coding Sequences.
JO  - Science
JF  - Science
Y1  - 1982/02/19/
VL  - 215
IS  - 4535
M3  - Article
SP  - 985
EP  - 987
SN  - 00368075
AB  - The 14S messenger RNA (1300 to 1500 nucleotides) for the αA chain of a-crystallin of the mammalian lens is nearly three times larger than required to code for the polypeptide that contains 173 amino acids. As a means of accounting for this anomaly, a complementary DNA clone for the mouse oA-crystallin messenger RNA was constructed in pBR322 and sequenced. Derivation of the protein sequence from the nucleic acid sequence showed that mouse αA-crystallin is similar to that of other organisms. The messenger RNA contains 536 nucleotides located on the 3' side of the coding region, excluding the polyadenylate stretch. This 3' sequence does not encode any other crystallin and has multiple termination codons in the three possible reading frames. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003653; KING, CHARLES R. 1; SHINOHARA, TOSHIMICHI 1; PIATIGORSKY, JORAM 1; Affiliations: 1: Laboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p985; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BRUNELLO, N.
AU  - CHUANG, D. M.
AU  - COSTA, E.
T1  - Different Synaptic Location of Mianserin and Imipramine Binding Sites.
JO  - Science
JF  - Science
Y1  - 1982/02/26/
VL  - 215
IS  - 4536
M3  - Article
SP  - 1112
EP  - 1115
SN  - 00368075
AB  - The high-affinity binding sites for mianserin and imipramine appear to be located in different neurons of rat brain. Studies in which lesions were produced with 5,7-dihydroxytryptamine and other studies in which the 5-hydroxytryptamine content was decreased with p-chlorophenylalanine indicate that some of the imipramine binding sites are on serotonin axon terminals and others are on nonserotonergic synapses. The sites that bind mianserin are on postsynaptic serotonin sites as well as on synapses of other neuronal systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003697; BRUNELLO, N. 1; CHUANG, D. M. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/26/1982, Vol. 215 Issue 4536, p1112; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - O'DONOHUE, THOMAS L.
AU  - HANDELMANN, GAIL E.
AU  - MILLER, RUSSELL L.
AU  - JACOBOWITZ, DAVID M.
T1  - N-Acetylation Regulates the Behavioral Activity of α-Melanotropin in a Multineurotransmitter Neuron.
JO  - Science
JF  - Science
Y1  - 1982/02/26/
VL  - 215
IS  - 4536
M3  - Article
SP  - 1125
EP  - 1127
SN  - 00368075
AB  - A multineurotransmitter neuronal system that synthesizes and secretes both acetylated and deacetylatedforms of a-melantropin and f-endorphin is present in rat and human brain. The N-acetylatedform of a-melanotropin had more potent behavioral effects than the deacetylated α-melanotropin. In the case of β-endorphin, however, the deacetylated form has been-shown to be more potent than the acetylated form. Enzymatic N-acetylation appears to be an important regulatory process for modulating the behavioral activity of peptides secreted from the opiomelanotropinergic multineurotransmitter neuron. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88003703; O'DONOHUE, THOMAS L. 1; HANDELMANN, GAIL E. 2; MILLER, RUSSELL L. 3; JACOBOWITZ, DAVID M. 4; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health and National Institute of General Medical Sciences, Bethesda, Maryland 20205; 2: Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21205; 3: Department of Pharmacology and Medicine, Howard University, Washington, D.C. 20019; 4: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 2/26/1982, Vol. 215 Issue 4536, p1125; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Moment, Gairdner
T1  - AGING IN MAMMALS.
JO  - BioScience
JF  - BioScience
Y1  - 1982/03//
VL  - 32
IS  - 3
M3  - Book Review
SP  - 209
EP  - 209
SN  - 00063568
AB  - The article reviews the book "Mammalian Models for Research on Aging."
KW  - Laboratory animals
KW  - Developmental biology
KW  - Nonfiction
KW  - Mammalian Models for Research on Aging (Book)
N1  - Accession Number: 28051432; Moment, Gairdner 1; Affiliations: 1 : Guest Scientist National Institute on Aging Professor of Biology Emeritus Goucher College Baltimore, MD;  Source Info: Mar1982, Vol. 32 Issue 3, p209; Subject Term: Laboratory animals; Subject Term: Developmental biology; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 691
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Lemanske, Jr., R. F.
AU  - Kaliner, M. A.
T1  - The experimental production of increased eosinophils in rat late-phase reactions.
JO  - Immunology
JF  - Immunology
Y1  - 1982/03//
VL  - 45
IS  - 3
M3  - Article
SP  - 561
EP  - 568
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The effects of peripheral eosinophilia on the intensity, kinetics and cellular characteristics of rat cutaneous late-phase reactions (LPR) have been investigated. Two distinct methods of inducing peripheral eosinophilia did not alter either the intensity or the kinetics of LPR produced by the intradermal injection of anti-IgE, Compound 48/80, or isolated mast cell granules. Hypereosinophilic animals exhibited increased numbers of tissue eosinophils in LPR tissue sites which correlated with the elevations in their respective peripheral eosinophil counts: however, the absolute number of eosinophils present, although significant, was not impressive («10% of total). Our data suggest that, although rat LPR can be modulated to involve increased tissue eosinophils by increasing the numbers of peripheral blood eosinophils, no effects of these procedures on altering either the intensity or the kinetics of these reactions can be appreciated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EOSINOPHILIA
KW  - EOSINOPHILS
KW  - GRANULOCYTES
KW  - RATS as laboratory animals
KW  - EOSINOPHIL disorders
KW  - LABORATORY animals
N1  - Accession Number: 14004146; Lemanske, Jr., R. F. 1 Kaliner, M. A. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar82, Vol. 45 Issue 3, p561; Subject Term: EOSINOPHILIA; Subject Term: EOSINOPHILS; Subject Term: GRANULOCYTES; Subject Term: RATS as laboratory animals; Subject Term: EOSINOPHIL disorders; Subject Term: LABORATORY animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Small, Arnold
AU  - Teagno, Lorie
AU  - Madero, James
AU  - Gross, Howard
AU  - Eberts, Michael
T1  - A Comparison of Anorexics and Schizophrenics on Psychodiagnostic Measures.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1982///Spring1982
VL  - 1
IS  - 3
M3  - Article
SP  - 49
EP  - 56
PB  - John Wiley & Sons, Inc.
SN  - 02763478
N1  - Accession Number: 11975641; Small, Arnold 1 Teagno, Lorie 2 Madero, James 3 Gross, Howard 3 Eberts, Michael 3; Affiliation:  1: George Mason University & Family and Child Development Services of Va.  2: University of Maryland.  3: National Institute of Mental Health.; Source Info: Spring1982, Vol. 1 Issue 3, p49; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scudiero, Dominic A.
AU  - Moshell, Alan N.
AU  - Scarpinato, Ronald G.
AU  - Meyer, Sharon A.
AU  - Clatterbuck, Brian E.
AU  - Tarone, Robert E.
AU  - Robbins, Jay H.
T1  - Lymphoblastoid Lines and Skin Fibroblasts from Patients with Tuberous Sclerosis Are Abnormally Sensitive to Ionizing Radiation and to a Radiomemetic Chemical.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/03//
VL  - 78
IS  - 3
M3  - Article
SP  - 234
EP  - 238
SN  - 0022202X
AB  - Lymphoblastoid lines, derived by transforming peripheral blood lymphocytes with Epstein-Barr virus, and skin fibroblast lines were established from two patients with tuberous sclerosis. The number of viable lymphoblastoid cells was determined by their ability to exclude the vital dye trypan blue after their irradiation with x-rays or 254 nm ultraviolet light. The growth of fibroblasts was determined by their ability to form colonies after treatment with the radiomimetic, DNA-damaging chemical <em>N</em>-methyl-<em>N'</em>-nitro-<em>N</em>-nitrosoguanidine. The tuberous sclerosis lymphoblastoid lines were hypersensitive to x-rays but had normal sensitivity to the ultraviolet radiation. The tuberous sclerosis fibroblast lines were hypersensitive to the <em>N</em>-methyl-<em>N'</em>-nitro-<em>N</em>-nitrosoguanidine. The hypersensitivity of tuberous sclerosis cells to x-rays and to <em>N</em>-methyl-<em>N'</em>-nitro-<em>N</em>-nitrosoguanidine is believed to reflect defective repair of DNA damaged by these agents and may provide the basis for <em>in vitro</em>, including prenatal, diagnostic tests for tuberous sclerosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TUBEROUS sclerosis
KW  - MENTAL disabilities
KW  - ULTRAVIOLET radiation
KW  - LEUCOCYTES
KW  - EPSTEIN-Barr virus
KW  - X-rays
N1  - Accession Number: 12506550; Scudiero, Dominic A. 1,2 Moshell, Alan N. 1,2 Scarpinato, Ronald G. 1,2 Meyer, Sharon A. 1,2 Clatterbuck, Brian E. 1,2 Tarone, Robert E. 1,2 Robbins, Jay H. 1,2; Affiliation:  1: Chemical Carcinogenesis Program, Frederick Cancer Research Center, Frederick, Maryland.  2: Dermatology and Biometry Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1982, Vol. 78 Issue 3, p234; Subject Term: TUBEROUS sclerosis; Subject Term: MENTAL disabilities; Subject Term: ULTRAVIOLET radiation; Subject Term: LEUCOCYTES; Subject Term: EPSTEIN-Barr virus; Subject Term: X-rays; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12506550
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Malley, James D.
T1  - Simultaneous Confidence Intervals for Ratios of Normal Means.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1982/03//
VL  - 77
IS  - 377
M3  - Article
SP  - 170
SN  - 01621459
AB  - Given one or more groups of multivariate normal samples, methods are presented for forming, simultaneous confidence intervals of all ratios of linear forms of the mean vectors. The methods cover the cases of equal or unequal covariances. In a simultaneous inference context, they are multivariate extensions of a method due to Fieller (1954) for estimation of the ratio of two normal means. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MULTIVARIATE analysis
KW  - ANALYSIS of covariance
KW  - ANALYSIS of variance
KW  - ESTIMATION theory
KW  - MATHEMATICAL statistics
KW  - LINEAR models (Statistics)
KW  - MATHEMATICAL models
KW  - SIMULTANEOUS equations
KW  - CONFIDENCE intervals
KW  - Constrained estimation.
KW  - Multivariate normal
KW  - Ratio estimation
KW  - Simultaneous inference
N1  - Accession Number: 4603811; Malley, James D. 1; Affiliations: 1: Research and consulting statistician, Laboratory of Statistical and Mathematical Methodology, Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20205.; Issue Info: Mar1982, Vol. 77 Issue 377, p170; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: MATHEMATICAL models; Subject Term: SIMULTANEOUS equations; Subject Term: CONFIDENCE intervals; Author-Supplied Keyword: Constrained estimation.; Author-Supplied Keyword: Multivariate normal; Author-Supplied Keyword: Ratio estimation; Author-Supplied Keyword: Simultaneous inference; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-06540-037
AN  - 2006-06540-037
AU  - Newman, Sidney H.
T1  - A Multidisciplinary Approach to Fertility and Family Planning.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1982/03//
VL  - 27
IS  - 3
SP  - 224
EP  - 225
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06540-037. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Newman, Sidney H.; Center for Population Research, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Birth Control; Fertility. Minor Descriptor: Social Sciences. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Shain, Rochelle N. (Ed); Pauerstein, Carl J. (Ed). Fertility Control: Biologic and Behavioral Aspects=Hagerstown, Md.: Harper & Row, 1980 459 pp. $35 00 cloth; 1980. Page Count: 2. Issue Publication Date: Mar, 1982. 
AB  - Reviews the book, Fertility Control: Biologic and Behavioral Aspects edited by Rochelle N. Shain and Carl J. Pauerstein (1980). This is the first book in which there has been a significant amalgamation of behavioral-social, biological, and clinical sciences involved in research and training in the areas of fertility and fertility regulation, as well as in family planning activities. The value of the book is enhanced by the clarity of writing; specific efforts were made to diminish the language barrier that usually exists between behavioral-social and biomedical scientists. This reviewer suggests that if this book is revised, consideration be given to increasing the kinds of behavioral-social science specialists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - fertility
KW  - family planning
KW  - fertility regulation
KW  - 1982
KW  - Birth Control
KW  - Fertility
KW  - Social Sciences
KW  - 1982
U2  - Shain, Rochelle N. (Ed); Pauerstein, Carl J. (Ed). (1980); Fertility Control: Biologic and Behavioral Aspects; Hagerstown, Md.: Harper & Row, 1980 459 pp. $35 00 cloth
DO  - 10.1037/021032
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - BUSTIN, MICHAEL
AU  - REISCH, JOANNE
AU  - EINCK, LEO
AU  - KLIPPEL, JOHN H.
T1  - Autoantibodies to Nucleosomal Proteins: Antibodies to HMG-17 in Autoimmune Diseases.
JO  - Science
JF  - Science
Y1  - 1982/03/05/
VL  - 215
IS  - 4537
M3  - Article
SP  - 1245
EP  - 1247
SN  - 00368075
AB  - The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88017655; BUSTIN, MICHAEL 1; REISCH, JOANNE 1; EINCK, LEO 1; KLIPPEL, JOHN H. 2; Affiliations: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: Arthritis and Rheumatism Branch, National Institute of Arthritis, Bethesda, Maryland 20205; Issue Info: 3/ 5/1982, Vol. 215 Issue 4537, p1245; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - RUDA, M. A.
T1  - Opiates and Pain Pathways: Demonstration of Enkephalin Synapses on Dorsal Horn Projection Neurons.
JO  - Science
JF  - Science
Y1  - 1982/03/19/
VL  - 215
IS  - 4539
M3  - Article
SP  - 1523
EP  - 1525
SN  - 00368075
AB  - The participation of the opiate peptide enkephalin in the neural circuitry of the dorsal horn was examined at the light and ultrastructural level through the use of the combined techniques of immunocytochemistry and retrograde transport of horseradish peroxidase. Enkephalin immunoreactive axonal endings made direct synaptic contact with the soma and proximal dendrites of dorsal horn thalamic projection neurons. This observation demonstrates that one major synaptic site of enkephalin modulation of the transfer of nociceptive information in the dorsal horn is on the projection neurons themselves. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84705088; RUDA, M. A. 1; Affiliations: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20205; Issue Info: 3/19/1982, Vol. 215 Issue 4539, p1523; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hoover, Robert
AU  - Hartge, Patricta
T1  - Non-Nutritive Sweeteners and Bladder Cancer.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1982/04//
VL  - 72
IS  - 4
M3  - Article
SP  - 382
EP  - 383
PB  - American Public Health Association
SN  - 00900036
AB  - The article comments on an analysis conducted by Alexander M. Walker et al., regarding the U.S. National Cancer Institute's study on non-nutritive sweeteners and bladder cancer. The authors state that the reanalysis of Walker et al., has yielded the same findings that they reported, that there is no evidence of any association between bladder cancer risk and past consumption of artificial sweeteners. Walker et al., claim that control for a variety of factors through multivariate techniques diminished the plausibility of earlier interpretations of the subgroup findings.
KW  - CANCER research
KW  - NONNUTRITIVE sweeteners
KW  - SWEETENERS
KW  - BLADDER
KW  - URINARY organs
KW  - NATIONAL Cancer Institute (U.S.)
KW  - WALKER, Alexander M.
N1  - Accession Number: 4949144; Hoover, Robert 1 Hartge, Patricta 1; Affiliation:  1: Environmental Epidemiology Branch, National Cancer Institute; Source Info: Apr1982, Vol. 72 Issue 4, p382; Subject Term: CANCER research; Subject Term: NONNUTRITIVE sweeteners; Subject Term: SWEETENERS; Subject Term: BLADDER; Subject Term: URINARY organs; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: WALKER, Alexander M.; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brown, W. R.
AU  - Smith, P. D.
AU  - Lee, Evelyn
AU  - McCalmon, R. T.
AU  - Nagura, H.
T1  - A search for an enriched source of polymeric IgA in human thoracic duct lymph, portal vein blood and aortic blood.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/04//
VL  - 48
IS  - 1
M3  - Article
SP  - 85
EP  - 90
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Because human bile contains a lot of secretory IgA, it has been suspected that the human liver, like rat liver, transfers polymeric IgA from plasma to bile. Hence, a rich source of polymeric IgA might enter the general circulation of man. We examined human thoracic duct lymph, portal vein blood and aortic blood for content and molecular size of IgA. None of the fluids was found to have either a higher total concentration of IgA or a higher proportion of polymeric IgA than that found in peripheral venous blood. It is possible that hepatic clearance of plasma IgA does not occur in man to the extent that it does in the rat, and a relatively larger proportion of human biliary IgA might originate from synthesis in hepatobiliary tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - AORTIC paraganglia
KW  - BILIARY tract
KW  - BLOOD-vessels
KW  - PRESERVATION of organs, tissues, etc.
KW  - LIVER
N1  - Accession Number: 16334613; Brown, W. R. 1 Smith, P. D. 2 Lee, Evelyn 1 McCalmon, R. T. 3 Nagura, H. 4; Affiliation:  1: The Departments of Medicine (Gastroenterology) and Surgery, The Veterans Administration Medical Center, The University of Colorado School of Medicine, Denver, Colorado, USA  2: Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.  3: Immunological Associates of Denver, Denver, Colorado, USA.  4: The School of Medicine, Tokai University, Japan; Source Info: Apr1982, Vol. 48 Issue 1, p85; Subject Term: IMMUNOGLOBULINS; Subject Term: AORTIC paraganglia; Subject Term: BILIARY tract; Subject Term: BLOOD-vessels; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: LIVER; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-42249-011
AN  - 2013-42249-011
AU  - Davenport, Yolande B.
AU  - Adland, Marvin L.
T1  - Postpartum psychoses in female and male bipolar manic-depressive patients.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1982/04//
VL  - 52
IS  - 2
SP  - 288
EP  - 297
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Davenport, Yolande B., Chief Unit on Family Studies, Clinical Psychobiology Branch, Clinical Center, NIMH, Room 4S239, Bethesda, MD, US, 20205
N1  - Accession Number: 2013-42249-011. PMID: 7081399 Partial author list: First Author & Affiliation: Davenport, Yolande B.; Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Major Depression; Risk Factors. Minor Descriptor: Fathers; Human Females; Mania; Psychosis. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 1982. 
AB  - Bipolar manic-depressive women are considered a special risk for recurrence of a childbirth-related affective episode. In a chart study of 40 fathers who are former bipolar patients, 21 had histories of an affective episode in proximity to a wife's pregnancy. When these bipolar fathers were compared with the 19 for whom no such episodes were recorded, differences were found on several parameters. Therapeutic implications of the findings are considered, und recommendations for further study are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - postpartum psychoses
KW  - bipolar disorders
KW  - manic depressive patients
KW  - special risk
KW  - 1982
KW  - Bipolar Disorder
KW  - Major Depression
KW  - Risk Factors
KW  - Fathers
KW  - Human Females
KW  - Mania
KW  - Psychosis
KW  - 1982
DO  - 10.1111/j.1939-0025.1982.tb02689.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - O'Brien, Stephen J.
AU  - Nash, William G.
T1  - Genetic Mapping in Mammals: Chromosome Map of Domestic Cat.
JO  - Science
JF  - Science
Y1  - 1982/04/16/
VL  - 216
IS  - 4543
M3  - Article
SP  - 257
EP  - 265
SN  - 00368075
N1  - Accession Number: 84705236; O'Brien, Stephen J. 1; Nash, William G. 2; Affiliations: 1: Chief, Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Senior staff scientist, Carcinogenesis Intramural Research Program, National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 4/16/1982, Vol. 216 Issue 4543, p257; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KIRSCH, ILAN R.
AU  - MORTON, CYNTHIA C.
AU  - NAKAHARA, KENNETH
AU  - LEDER, PHILIP
T1  - Human Immunoglobulin Heavy Chain Genes Map to a Region of Translocations in Malignant B Lymphocytes.
JO  - Science
JF  - Science
Y1  - 1982/04/16/
VL  - 216
IS  - 4543
M3  - Article
SP  - 301
EP  - 303
SN  - 00368075
AB  - A human immunoglobulin heavy chain (y4) gene is mapped by chromosome hybridization in situ. This gene is located at band J4q32, a site commonly involved in a chromosomal translocation characteristic of malignant B cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84705264; KIRSCH, ILAN R. 1; MORTON, CYNTHIA C. 2; NAKAHARA, KENNETH 3; LEDER, PHILIP 4,5; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298; 3: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20205; 4: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda; 5: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; Issue Info: 4/16/1982, Vol. 216 Issue 4543, p301; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hu, P. C.
AU  - COLE, R. M.
AU  - HUANG, Y. S.
AU  - GRAHAM, J. A.
AU  - GARDNER, D. E.
AU  - COLLIER, A. M.
AU  - CLYDE JR., W. A.
T1  - Mycoplasma pneumoniae Infection: Role of a Surface Protein in the Attachment Organelle.
JO  - Science
JF  - Science
Y1  - 1982/04/16/
VL  - 216
IS  - 4543
M3  - Article
SP  - 313
EP  - 315
SN  - 00368075
AB  - Attachment of Mycoplasma pneumoniae to host cells by means of a specialized terminus initiates infection. Monoclonal antibodies to a surface protein (P1) inhibit this process, and react with a region of the tip covered with peplomer-like particles. Since antibodies against the P1 protein are generated by natural and experimental infection and by immunization, the substance may be an important determinant of protective immunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84705270; Hu, P. C. 1; COLE, R. M. 2; HUANG, Y. S. 3; GRAHAM, J. A. 3; GARDNER, D. E. 3; COLLIER, A. M. 4; CLYDE JR., W. A. 4; Affiliations: 1: Northrop Service Inc.- Environmental Science, Research Triangle Park, North Carolina 27709; 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Health Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711; 4: Department of Pediatrics, Frank Porter Graham Child Development Center, and Center for Environmental Health and Medical Sciences, University of North Carolina, Chapel Hill 27514; Issue Info: 4/16/1982, Vol. 216 Issue 4543, p313; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HIRAKAWA, TADASHI
AU  - KAKUNAGA, TAKEO
AU  - FUJIKI, HIROTA
AU  - SUGIMURA, TAKASHI
T1  - A New Tumor-Promoting Agent, Dihydroteleocidin B, Markedly Enhances Chemically Induced Malignant Cell Transformation.
JO  - Science
JF  - Science
Y1  - 1982/04/30/
VL  - 216
IS  - 4545
M3  - Article
SP  - 527
EP  - 529
SN  - 00368075
AB  - Teleocidin, which was isolated from mycelia of Streptomyces, is a potent tumor promoter in mouse skin. The catalytically hydrogenated compound dihydroteleocidin B markedly enhanced malignant cell transformation induced by 3-methylcholanthrene or ultraviolet radiation. Dihydroteleocidin B was at least 100 times more effective in enhancing transformation than 12-O-tetradecanoyl phorbol-13- acetate, the strongest promoter known until now, whereas both promoters showed equal capacities to induce early membrane effects and DNA synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84705358; HIRAKAWA, TADASHI 1; KAKUNAGA, TAKEO 1; FUJIKI, HIROTA 2; SUGIMURA, TAKASHI 2; Affiliations: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: National Cancer Center Research Institute, Tokyo 104, Japan; Issue Info: 4/30/1982, Vol. 216 Issue 4545, p527; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Moment, Gairdner
T1  - VANISHED SPECIES.
JO  - BioScience
JF  - BioScience
Y1  - 1982/05//
VL  - 32
IS  - 5
M3  - Book Review
SP  - 345
EP  - 345
SN  - 00063568
AB  - The article reviews the book "The Doomsday Book of Animals: A Natural History of Vanished Species," by David Day.
KW  - Animals & history
KW  - Nonfiction
KW  - Day, David
KW  - Doomsday Book of Animals: A Natural History of Vanished Species, The (Book)
N1  - Accession Number: 28051504; Moment, Gairdner 1; Affiliations: 1 : Goucher College Guest Scientist National Institute on Aging Gerontology Research Center Baltimore, MD 21224;  Source Info: May1982, Vol. 32 Issue 5, p345; Subject Term: Animals & history; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 656
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Tsokos, G. C.
AU  - Balow, J. E.
AU  - Huston, D. P.
AU  - Wei, N.
AU  - Decker, J. L.
T1  - Effect of plasmapheresis on T and B lymphocyte functions in patients with systemic lupus erythematosus: a double blind study.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/05//
VL  - 48
IS  - 2
M3  - Article
SP  - 449
EP  - 457
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Nine patients with active systemic lupus erythematosus entered a double-blind randomized trial to study the therapeutic effect of vigorous versus sham reinfusion plasmapheresis. Four of them received real plasmapheresis while five received sham reinfusion plasmapheresis. In the present communication we report the effects of these procedures on T lymphocytes in peripheral mono nuclear cells, proliferative responses to mitogens, allogeneic mixed lymphocyte reaction and cell-mediated lympho lysis, as well as the effect of plasmapheresis on the spontaneous and pokeweed mitogen induced immunoglobulin secreting cells in peripheral blood. Several mono nuclear cell functions were abnormal at the beginning of the study but no significant changes related to plasmapheresis occurred in any of the parameters studied. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN diseases
KW  - AUTOIMMUNE diseases
KW  - SYSTEMIC lupus erythematosus
KW  - VASCULAR diseases
KW  - B cells
KW  - LEUCOCYTES
N1  - Accession Number: 16346375; Tsokos, G. C. 1 Balow, J. E. 2 Huston, D. P. 1 Wei, N. 1 Decker, J. L. 2; Affiliation:  1: The Arthritis and Rheumatism Branch. National Institute of Arthritis, Diabetes. Digestive and Kidney Diseases,  2: National Institutes of Health, Bethesda, Maryland. USA; Source Info: May1982, Vol. 48 Issue 2, p449; Subject Term: SKIN diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: VASCULAR diseases; Subject Term: B cells; Subject Term: LEUCOCYTES; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rollwagen, Florence M.
AU  - Mathieson, Bonnie J.
AU  - Asofsky, R.
T1  - Positive selection of T-cell subsets I. PROLIFERATIVE RESPONSES OF LYT 2 SEPARATED THYMOCYTES AND SPLENIC T CELLS.
JO  - Immunology
JF  - Immunology
Y1  - 1982/05//
VL  - 46
IS  - 1
M3  - Article
SP  - 49
EP  - 58
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Flow microfluorometry analysis of peanut lectin non-agglutinable (PNA-) thymocytes (ThC) reveals the existence of 30%-50% Lyt 1,2,3+ and 50%-70% Lyt 1+,2,3- subpopulations. Using positive selection on anti-immunoglobulin-coated (Mage) plates, we selected PNA- Lyt 2+ and PNA- Lyt 2- ThC as well as their peripheral counterparts in the spleen. These populations were tested in parallel for their ability to respond to concanavalin A (Con A) and phytohaemagglutinin (PHA), to respond to allogeneic stimulation in the mixed lymphocyte reaction (MLR); ThC subpopulations were also tested for their ability to provide synergy with lymph node cells (LNC) in the MLR. It was found that (a) Lyt 2- cells of both thymic and splenic origin responded to all doses of Con A or PHA; (b) PNA- Lyt 2+ ThC were unresponsive to Con A or PHA, whereas splenic Lyt 2+ T cells responded to low doses of mitogens; and (c) PNA- ThC of both Lyt phenotypes responded in a MLR and provided synergy with LNC in the MLR. These data support the notion that Lyt 2+ cells of either PNA- or PNA+ subpopulations must undergo post-thymic maturation before becoming responsive to low doses of T-cell mitogens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - CELL proliferation
KW  - FLUORIMETRY
KW  - ANTI-immunoglobulin autoantibodies
KW  - HEMAGGLUTININ
KW  - LYMPHOCYTES
KW  - MITOGENS
N1  - Accession Number: 13933580; Rollwagen, Florence M. 1 Mathieson, Bonnie J. 1 Asofsky, R. 1; Affiliation:  1: Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May82, Vol. 46 Issue 1, p49; Subject Term: T cells; Subject Term: CELL proliferation; Subject Term: FLUORIMETRY; Subject Term: ANTI-immunoglobulin autoantibodies; Subject Term: HEMAGGLUTININ; Subject Term: LYMPHOCYTES; Subject Term: MITOGENS; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Froese, A.
AU  - Helm, R. M.
AU  - Conrad, D. H.
AU  - Isersky, C.
AU  - Ishizaka, T.
AU  - Kulczycki Jr., A.
T1  - Comparison of the receptors for IgE of various rat basophilic leukaemia cell lines I. RECEPTORS ISOLATED BY IgE-SEPHAROSE AND IgE AND ANTI-IgE.
JO  - Immunology
JF  - Immunology
Y1  - 1982/05//
VL  - 46
IS  - 1
M3  - Article
SP  - 107
EP  - 116
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Receptors for IgE of rat basophilic leukaemia (RBL) cells, maintained in different laboratories were isolated by means of IgE-Sepharose or IgE and anti-IgE, and characterized by SDS-polyacrylamide gel electrophoresis. All cell lines were found to be associated with a receptor molecule (R) which could be isolated either with IgE-Sepharose or IgE and anti-IgE and a second receptor (H) which could only be isolated with the aid of IgE-Sepharose. The relative amounts of these two molecules, as isolated from surface iodinated cells, varied from one RBL cell line to the other and their apparent molecular weights were not identical on all cell lines. Since comparisons were made on the same gel using receptors isolated from cells labelled with different isotopes of iodine, differences in molecular weight must be considered as being intrinsic and not due to methodological variations. These results provide an explanation why differences were observed among receptors for IgE as characterized in various laboratories. In spite of the fact that the various RBL cell lines originated from the same chemically-induced tumour they have, over the years, undergone changes which are reflected in the receptors for IgE. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL receptors
KW  - IMMUNOGLOBULIN E
KW  - CELL lines
KW  - LEUKEMIA
KW  - GEL electrophoresis
KW  - CELL separation
KW  - MOLECULES
N1  - Accession Number: 13933734; Froese, A. 1 Helm, R. M. 1 Conrad, D. H. 1 Isersky, C. 1 Ishizaka, T. 1 Kulczycki Jr., A. 1; Affiliation:  1: M.R.C. Group in Allergy Research, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada; Medical College of Virginia, Virginia Commonwealth University, Richmond, Va.; Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Md; Department of Medicine, The Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Md and The Department of Medicine, Washington University School of Medicine, St. Louis, Mo., U.S.A.; Source Info: May82, Vol. 46 Issue 1, p107; Subject Term: CELL receptors; Subject Term: IMMUNOGLOBULIN E; Subject Term: CELL lines; Subject Term: LEUKEMIA; Subject Term: GEL electrophoresis; Subject Term: CELL separation; Subject Term: MOLECULES; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Froese, A.
AU  - Helm, R. M.
AU  - Conrad, D. H.
AU  - Isersky, C.
AU  - Ishizaka, T.
T1  - Comparison of the receptors for IgE of various rat basophilic leukaemia cell lines II. STUDIES WITH DIFFERENT ANTI-RECEPTOR ANTISERA.
JO  - Immunology
JF  - Immunology
Y1  - 1982/05//
VL  - 46
IS  - 1
M3  - Article
SP  - 117
EP  - 123
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Receptors for IgE of rat basophilic leukaemia (RBL) cells, maintained in different laboratories were isolated by means of various anti-receptor antisera, and characterized by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. Most antisera were shown to react with a receptor designated H and which, as shown previously, could be isolated by IgE-Sepharose but not by a combination of IgE and anti-IgE. Only two highly purified anti-receptor antibody preparations, which had been purified by adsorption to and elution from rat basophilic leukaemia cells, reacted primarily with a second kind of receptor molecule which had previously been designated R. Some indirect evidence was obtained which suggests that H is a highly immunogenic molecule. It was confirmed that the apparent molecular weight of H-like molecules varied on different RBL cell lines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL receptors
KW  - IMMUNOGLOBULIN E
KW  - CELL lines
KW  - LEUKEMIA
KW  - IMMUNE serums
KW  - POLYACRYLAMIDE gel electrophoresis
KW  - IMMUNOGENETICS
N1  - Accession Number: 13933902; Froese, A. 1 Helm, R. M. 1 Conrad, D. H. 1 Isersky, C. 1 Ishizaka, T. 1; Affiliation:  1: M.R.C. Group in Allergy Research, Department of Immunology, University of Manitoba, Winnipeg, Manitoba; Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia; Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, and the Department of Medicine, The Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Maryland, U.S.A.; Source Info: May82, Vol. 46 Issue 1, p117; Subject Term: CELL receptors; Subject Term: IMMUNOGLOBULIN E; Subject Term: CELL lines; Subject Term: LEUKEMIA; Subject Term: IMMUNE serums; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: IMMUNOGENETICS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Froese, A.
AU  - Helm, R. M.
AU  - Conrad, D. H.
AU  - Isersky, C.
AU  - Ishizaka, T.
T1  - Comparison of the receptors for IgE of various rat basophilic leukaemia cell lines II. STUDIES WITH DIFFERENT ANTI-RECEPTOR ANTISERA.
JO  - Immunology
JF  - Immunology
Y1  - 1982/05//
VL  - 46
IS  - 1
M3  - Article
SP  - 117
EP  - 123
SN  - 00192805
AB  - Receptors for IgE of rat basophilic leukaemia (RBL) cells, maintained in different laboratories were isolated by means of various anti-receptor antisera, and characterized by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. Most antisera were shown to react with a receptor designated H and which, as shown previously, could be isolated by IgE-Sepharose but not by a combination of IgE and anti-IgE. Only two highly purified anti-receptor antibody preparations, which had been purified by adsorption to and elution from rat basophilic leukaemia cells, reacted primarily with a second kind of receptor molecule which had previously been designated R. Some indirect evidence was obtained which suggests that H is a highly immunogenic molecule. It was confirmed that the apparent molecular weight of H-like molecules varied on different RBL cell lines. [ABSTRACT FROM AUTHOR]
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KW  - CELL receptors
KW  - IMMUNOGLOBULIN E
KW  - CELL lines
KW  - LEUKEMIA
KW  - IMMUNE serums
KW  - POLYACRYLAMIDE gel electrophoresis
KW  - IMMUNOGENETICS
N1  - Accession Number: 13933902; Froese, A. 1; Helm, R. M. 1; Conrad, D. H. 1; Isersky, C. 1; Ishizaka, T. 1; Source Information: May82, Vol. 46 Issue 1, p117; Subject: CELL receptors; Subject: IMMUNOGLOBULIN E; Subject: CELL lines; Subject: LEUKEMIA; Subject: IMMUNE serums; Subject: POLYACRYLAMIDE gel electrophoresis; Subject: IMMUNOGENETICS; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Schoenberg, Ronald
T1  - Multiple Indicator Models: Estimation of Unconstrained Construct Means and Their Standard Errors.
JO  - Sociological Methods & Research
JF  - Sociological Methods & Research
Y1  - 1982/05//
VL  - 10
IS  - 4
M3  - Article
SP  - 421
SN  - 00491241
AB  - Expressions are given for the calculation of the estimates and the standard errors of the estimates of the unconstrained means of the constructs in multiple indicator models. If the "reference" indicators - that is, the indicatory whose loadings are fixet to I., thereby identifying the variance of the construct and establishing its scale or units of measure are exclusive - that is, load only on the construct for which it is a "reference" - then the construct means are simply the means of the reference indicators. [ABSTRACT FROM AUTHOR]
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KW  - FALLACIES (Logic)
KW  - SCIENTIFIC errors
KW  - ESTIMATION theory
KW  - ESTIMATION bias
KW  - DECISION making
KW  - SOCIAL science research
N1  - Accession Number: 5864632; Schoenberg, Ronald 1; Source Information: May82, Vol. 10 Issue 4, p421; Subject: FALLACIES (Logic); Subject: SCIENTIFIC errors; Subject: ESTIMATION theory; Subject: ESTIMATION bias; Subject: DECISION making; Subject: SOCIAL science research; Number of Pages: 13p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - CHEVILLARD, C.
AU  - SAAVEDRA, J. M.
T1  - High Angiotensin-Converting Enzyme Activity in the Neurohypophysis of Brattleboro Rats.
JO  - Science
JF  - Science
Y1  - 1982/05/07/
VL  - 216
IS  - 4546
M3  - Article
SP  - 646
EP  - 647
SN  - 00368075
AB  - The activity of angiotensin-converting enzyme is significantly higher in the intermediate and posterior pituitary lobes of Brattleboro rats than in Long-Evans control rats. The high activity level was reversed by vasopressin treatment. Conversely, angiotensin-converting enzyme activity was significantly lower in the anterior pituitary of B-rattleboro rats than in Long-Evans rats, and this activity level was not affected by vasopressin. These findings suggest an inverse relation between vasopressin and angiotensin systems in the posterior and intermediate lobes of the pituitary gland. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705418; CHEVILLARD, C. 1; SAAVEDRA, J. M. 1; Affiliations: 1: Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 5/ 7/1982, Vol. 216 Issue 4546, p646; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - TWARDZIK, DANIEL R.
AU  - TODARO, GEORGE J.
AU  - MARQUARDT, HANS
AU  - REYNOLDS JR., FRED H.
AU  - STEPHENSON, JOHN R.
T1  - Transformation Induced by Abelson Murine Leukemia Virus Involves Production of a Polypeptide Growth Factor.
JO  - Science
JF  - Science
Y1  - 1982/05/21/
VL  - 216
IS  - 4548
M3  - Article
SP  - 894
EP  - 897
SN  - 00368075
AB  - Rat embryo fibroblasts transformed by Abelson murine leukemia virus (MuLV) produce and release a transforming growth factor (TGF). Production of this factor is correlated with a tyrosine-specific protein kinase that is functionally active and is associated with the major Abelson MuLV gene product, P120. Transformation- defective mutants of Abelson MuLV do not transform cells, do not have their virus coded transforming gene product phosphorylated in tyrosine, and do not induce TGF production. Abelson AMuLV-induced TGF morphologically transforms cells in culture, competes with 125I-labeled epidermal growth factor (EGF) for binding to cell receptors, and induces phosphorylation of tyrosine acceptor sites in the 160,000-dalton EGF membrane receptor. After purification to homogeneity, Abelson virus-induced TGF migrates as a single polypeptide with an apparent size of 7400 daltons as determined by sodium dodecyl sulfate-polyacrylamide gel electro- phoresis. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705532; TWARDZIK, DANIEL R. 1; TODARO, GEORGE J. 1; MARQUARDT, HANS 1; REYNOLDS JR., FRED H. 2; STEPHENSON, JOHN R. 3; Affiliations: 1: Laboratory of Viral Carcinogenesis, 69,000 National Cancer Institute, Frederick, Maryland 21701; 2: Carcinogenesis Intramural Research- Program, Frederick Cancer Research Facility, Frederick 21701; 3: Laboratory of Viral Carcinogenesis; Issue Info: 5/21/1982, Vol. 216 Issue 4548, p894; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Ward, Douglas F.
AU  - Gottesman, Max. E.
T1  - Suppression of Transcription Termination by Phage Lambda.
JO  - Science
JF  - Science
Y1  - 1982/05/28/
VL  - 216
IS  - 4549
M3  - Article
SP  - 946
EP  - 951
SN  - 00368075
N1  - Accession Number: 84705540; Ward, Douglas F. 1; Gottesman, Max. E. 1; Affiliations: 1: Biochemical Genetics Section of Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 5/28/1982, Vol. 216 Issue 4549, p946; Number of Pages: 6p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - SPRING, KENNETH R.
T1  - Ion Transport by Epithelia.
JO  - Science
JF  - Science
Y1  - 1982/05/28/
VL  - 216
IS  - 4549
M3  - Article
SP  - 978
EP  - 979
SN  - 00368075
N1  - Accession Number: 84705557; SPRING, KENNETH R. 1; Affiliations: 1: Laboratory of Kidney and Electrolyte Metabolism, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/28/1982, Vol. 216 Issue 4549, p978; Number of Pages: 2p; Document Type: Article
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TY  - JOUR
AU  - TAMARKIN, LAWRENCE
AU  - DANFORTH, DAVID
AU  - LICHTER, ALAN
AU  - DEMOSS, ERNEST
AU  - COHEN, MICHAEL
AU  - CHABNER, BRUCE
AU  - LIPPMAN, MARC
T1  - Decreased Nocturnal Plasma Melatonin Peak in Patients with Estrogen Receptor Positive Breast Cancer.
JO  - Science
JF  - Science
Y1  - 1982/05/28/
VL  - 216
IS  - 4549
M3  - Article
SP  - 1003
EP  - 1005
SN  - 00368075
AB  - Plasma melatonin concentrations were determined over a period of 24 hours in 20 women with clinical stage I or II breast cancer. In ten of the patients, whose tumors were estrogen receptor positive, the nocturnal increase in plasma melatonin was much lower than that observed in eight control subjects. Women with the lowest peak concentration of melatonin had tumors with the highest concentrations of estrogen receptors. A significant correlation was found between the peak plasma melatonin concentration and the tumor estrogen receptor concentration in 19 of the patients. These data suggest that low nocturnal melatonin concentrations may indicate the presence of estrogen receptor positive breast cancer and could conceivably have etiologic significance. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705571; TAMARKIN, LAWRENCE 1; DANFORTH, DAVID 2; LICHTER, ALAN 2; DEMOSS, ERNEST 2; COHEN, MICHAEL 2; CHABNER, BRUCE 2; LIPPMAN, MARC 2; Affiliations: 1: Intramural Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Medicine, Radiation, Surgery, and Clinical Pharmacology Branches, National Cancer Institute, Bethesda 20205; Issue Info: 5/28/1982, Vol. 216 Issue 4549, p1003; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Rogers, M. J.
T1  - H-2b bound to egg lecithin liposomes: biochemical and functional properties.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/06//
VL  - 48
IS  - 3
M3  - Article
SP  - 561
EP  - 573
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Purified H-2b and H-2a molecules were bound to egg lecithin liposomes by a detergent dialysis procedure. Analysis of the liposomes indicated that only 30-50% of bound H-2b is oriented with the hydrophilic antigenic portion of the molecule toward the outside of the liposome. Saturation of the liposomes occurred at a ratio of 64 molecules of egg lecithin per molecule of H-2b. Liposomes containing H-2 molecules were capable of stimulating spleen cells from primed donors to produce specific, alloreactive, cytotoxic T lymphocytes in vitro. Stimulation was dependent on adherent cells present in the responder spleen cells. Optimal stimulation occurred with highly saturated liposomes and at a ratio of 4-8 µg of H-2b per 8 × 106 responder cells. [ABSTRACT FROM AUTHOR]
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KW  - PHOSPHOLIPIDS
KW  - CYTOPLASM
KW  - LIPOSOMES
KW  - BILAYER lipid membranes
KW  - LECITHIN
KW  - LYMPHOID tissue
KW  - LEUCOCYTES
KW  - T cells
N1  - Accession Number: 15990974; Rogers, M. J. 1; Affiliation:  1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Jun1982, Vol. 48 Issue 3, p561; Subject Term: PHOSPHOLIPIDS; Subject Term: CYTOPLASM; Subject Term: LIPOSOMES; Subject Term: BILAYER lipid membranes; Subject Term: LECITHIN; Subject Term: LYMPHOID tissue; Subject Term: LEUCOCYTES; Subject Term: T cells; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; Number of Pages: 13p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Olivecrona, Thomas
AU  - Bengtsson, Gunilla
AU  - Osborne Jr., James C.
T1  - Molecular Properties of Lipoprotein Lipase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1982/06//6/1/82
VL  - 124
IS  - 3
M3  - Article
SP  - 629
EP  - 633
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The monomer molecular size of bovine lipoprotein lipase was evaluated by sedimentation equilibrium measurements and by gel permeation chromatography in 6 M guanidinium chloride. To establish molecular weight unequivocally we determined the partial specific volume (v) experimentally. This was done by analyzing equllibrium concentration profiles from analytical ultracentrifugation in 6 M guanidinium chloride using buffers made up in H20 and 2H20. The combined results gave a v of 0.71 ± 0.007 ml/g and a molecular weight of 41700 ± 1000 for monomeric bovine lipoprotein lipase. This value did not change upon mild tryptic digestion; the elution volume upon gel permeation chromatography in 6 M guanidinium chloride was also unaffected by treatment with trypsin. Sedimentation equilibrium measurements of the trypsin-treated material in the presence of reducing agents gave limiting molecular weights of 19000 and 23000, demonstrating that mild trypsin digestion cleaved lipoprotein lipase into two polypeptide chains of similar size held together by disulfide bonds. Mild trypsin digestion also resulted in a loss of secondary structure as determined by circular dichroic measurements. Discussion centers around the correlation between these effects of trypsin on the molecular properties of lipoprotein lipase and the previously reported effects on the kinetic properties of the enzyme. [ABSTRACT FROM AUTHOR]
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KW  - LIPOPROTEIN lipase
KW  - DIGESTIVE enzymes
KW  - PANCREATIC secretions
KW  - MOLECULAR weights
KW  - CRYOSCOPY
KW  - COLLOIDS
N1  - Accession Number: 15803474; Olivecrona, Thomas 1,2 Bengtsson, Gunilla 1,2 Osborne Jr., James C. 1,2; Affiliation:  1: Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Maryland.  2: Department of Physiological Chemistry, University of Umeå; Source Info: 6/1/82, Vol. 124 Issue 3, p629; Subject Term: LIPOPROTEIN lipase; Subject Term: DIGESTIVE enzymes; Subject Term: PANCREATIC secretions; Subject Term: MOLECULAR weights; Subject Term: CRYOSCOPY; Subject Term: COLLOIDS; Number of Pages: 5p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Ribi, E.
AU  - Granger, D. L.
AU  - Milner, K. C.
AU  - Yamamoto, K.
AU  - Strain, S. M.
AU  - Parker, R.
AU  - Smith, R. W.
AU  - Brehmer, W.
AU  - Azuma, I.
T1  - Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.
JO  - Immunology
JF  - Immunology
Y1  - 1982/06//
VL  - 46
IS  - 2
M3  - Article
SP  - 297
EP  - 305
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Factors contributing to protection against experimental tuberculosis have been studied with refined and well characterized fractions from mycobacteria and with certain unrelated antigens. Mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsion and were later challenged by aerosol. The minimal composition of an effective vaccine was P3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculoprotein, or a low-molecular-weight tuberculin-active peptide, or unrelated antigen such as bovine serum albumin or bacterial endotoxin. Development of a hypersensitivity granuloma in the lungs appeared to be essential to protection in this laboratory model. [ABSTRACT FROM AUTHOR]
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KW  - MYCOBACTERIA
KW  - TUBERCULOSIS
KW  - ANTIGENS
KW  - TUBERCULIN
KW  - GRANULOMA
KW  - IMMUNOLOGY
N1  - Accession Number: 13991040; Ribi, E. 1 Granger, D. L. 1 Milner, K. C. 1 Yamamoto, K. 2 Strain, S. M. 3 Parker, R. 3 Smith, R. W. 1 Brehmer, W. 4 Azuma, I. 2; Affiliation:  1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A  2: Institute of Immunological Science, Hokkaido University, Sapporo, Japan  3: Hamilton Biochemical Research Laboratory  4: Robert Koch Institute, Federal Health Office, 1000 Berlin 65, Germany; Source Info: Jun82, Vol. 46 Issue 2, p297; Subject Term: MYCOBACTERIA; Subject Term: TUBERCULOSIS; Subject Term: ANTIGENS; Subject Term: TUBERCULIN; Subject Term: GRANULOMA; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lin, K. T.
AU  - Lee, C. J.
T1  - Immune response of neonates to pneumococcal polysaccharide-protein conjugate.
JO  - Immunology
JF  - Immunology
Y1  - 1982/06//
VL  - 46
IS  - 2
M3  - Article
SP  - 333
EP  - 342
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Immune responses were studied in adult and young mice exposed to pneumococcal 6A and 19F polysaccharides (PSs), as well as 19F PS conjugated to proteins, e.g. human immunoglobulin G (HIgG), pneumococcal R61 cell wall polypeptide, and bovine serum albumin (BSA). Significantly higher IgM and IgG2 antibody titres were induced in mice receiving 19F PS-protein conjugates than in the control group receiving 19F PS alone. Maternal immunization with 19F PS-HIgG conjugate elicited a low immune response in the offspring. However, when young mice from immunized mothers were given an additional dose of polysaccharide-protein conjugate, they gave an antibody response greater than that of mice not given additional immumogen. Similarly, young mice exposed to 14-valent pneumocoral vaccine during gestation produced higher antibody response to 6A and 19F PSs. Secondary immunization of 19F PS or PS-protein conjugate at 1 or 2 weeks after primary immunization did not enhance antibody formation but rather suppressed the immune response to that polysaccharide. [ABSTRACT FROM AUTHOR]
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KW  - POLYSACCHARIDES
KW  - IMMUNOGLOBULIN G
KW  - PNEUMOCOCCAL vaccine
KW  - IMMUNE response
KW  - ANIMAL models in research
KW  - IMMUNOLOGY
N1  - Accession Number: 13991047; Lin, K. T. 1 Lee, C. J. 2; Affiliation:  1: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan  2: Bureau of Biologics, National Institutes of Health Building 29, Bethesda, Maryland, U.S.A.; Source Info: Jun82, Vol. 46 Issue 2, p333; Subject Term: POLYSACCHARIDES; Subject Term: IMMUNOGLOBULIN G; Subject Term: PNEUMOCOCCAL vaccine; Subject Term: IMMUNE response; Subject Term: ANIMAL models in research; Subject Term: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Saxena, R. K.
AU  - Saxena, Queen B.
AU  - Adler, W. H.
T1  - Identity of effector cells participating in the reverse antibody-dependent cell-mediated cytotoxicity.
JO  - Immunology
JF  - Immunology
Y1  - 1982/06//
VL  - 46
IS  - 2
M3  - Article
SP  - 459
EP  - 464
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Our previous work has shown that antibody-coated mouse spleen cells express enhanced cytotoxic activity against some Fc-receptor-bearing target tumour cells by a mechanism which appears to be similar to an antibody-dependent cell-mediated cytotoxicity (ADCC) reaction with reversed polarity of the antibody bridge (R-ADCC). In this report we have shown that (i) the levels of basal natural killer (NK), ADCC and R-ADCC cytotoxic activities in mouse spleen cells are strongly correlated with each other, (b) simultaneous induction of ADCC and R-ADCC reactions does not result in an additive cytotoxic response, and (iii) YAC cells which do not bear Fc receptors and are highly sensitive to lysis by NK cells, can specifically and competitively inhibit the ADCC and R-ADCC reactions. These results suggest that the R-ADCC reaction may be mediated by the same effector cell population as mediates NK and ADCC reactions against tumour target cells. [ABSTRACT FROM AUTHOR]
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KW  - CELL-mediated cytotoxicity
KW  - KILLER cells
KW  - MACROPHAGES
KW  - IMMUNOGLOBULINS
KW  - CELL populations
KW  - IMMUNOLOGY
N1  - Accession Number: 13991078; Saxena, R. K. 1 Saxena, Queen B. 1 Adler, W. H. 1; Affiliation:  1: Immunology Section, GRC, National Institute on Aging, National Institutes of Health, Maryland, U.S.A.; Source Info: Jun82, Vol. 46 Issue 2, p459; Subject Term: CELL-mediated cytotoxicity; Subject Term: KILLER cells; Subject Term: MACROPHAGES; Subject Term: IMMUNOGLOBULINS; Subject Term: CELL populations; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Hawley-Nelson, Pamela
AU  - Yaar, Mina
AU  - Martin, George H.
AU  - Katz, Stephen I.
T1  - Laminin and Bullous Pemphigoid Antigen Are Distinct Basement Membrane Proteins Synthesized by Epidermal Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/06//
VL  - 78
IS  - 6
M3  - Article
SP  - 456
EP  - 459
SN  - 0022202X
AB  - We sought to determine if laminin, a high molecular weight glycoprotein of basement membrane, is synthesized by epidermal cells and whether it is distinct from bullous pemphigoid (BP) antigen, another high molecular weight-protein of basement membrane. By indirect immunofluorescence we detected laminin in cultures of Pam cells (a mouse keratinocyte cell line) and normal human epidermal cells. To directly demonstrate its biosynthesis, we labeled the cells with radioactive amino acids and then extracted the cell layers with nonionic detergent. Using immunoprecipitation followed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and fluorography to identify radiolabeled laminin, we could precipitate the 2 chains of laminin from cell culture medium and extracts of the cell layers. BP antigen, immunoprecipitated from the cells, did not comigrate with laminin on SDS-PAGE. In addition, BP antigen could be immunoprecipitated from cell extracts depleted of laminin, and conversely, laminin could be immunoprecipitated from cell extracts depleted of BP antigen. We conclude that laminin is synthesized by epidermal cells (specifically, keratinocytes) and is distinct from BP antigen. [ABSTRACT FROM AUTHOR]
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KW  - GLYCOPROTEINS
KW  - ANTIGENS
KW  - EPIDERMIS
KW  - POLYACRYLAMIDE gel electrophoresis
KW  - PROTEINS
KW  - CELL culture
N1  - Accession Number: 12510132; Stanley, John R. 1 Hawley-Nelson, Pamela 2 Yaar, Mina 3 Martin, George H. 3 Katz, Stephen I. 2; Affiliation:  1: Department of Dermatology, Uniformed Services University of the Health Sciences, Maryland, U.S.A.  2: National Cancer Institute, Maryland, U.S.A.  3: National Institute of Dental Research of the National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun82, Vol. 78 Issue 6, p456; Subject Term: GLYCOPROTEINS; Subject Term: ANTIGENS; Subject Term: EPIDERMIS; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: PROTEINS; Subject Term: CELL culture; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12510132
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DB  - aph
ER  - 

TY  - JOUR
AU  - Chrousos, George P.
AU  - Peck, Gary L.
AU  - Gross, Earl G.
AU  - Cutler Jr., Gordon B.
AU  - Loriaux, D. Lynn
T1  - Adrenal Function in Women with Idiopathic Acne.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/06//
VL  - 78
IS  - 6
M3  - Article
SP  - 468
EP  - 471
SN  - 0022202X
AB  - The adrenal secretion of androgens was examined in 9 women (ages 19-39 yr) with postadolescent idiopathic acne and compared to age and sex-matched normal controls. Plasma dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (Δ4-A), cortisol, 17-hydroxyprogesterone, 11-deoxycortisol, and testosterone were measured by radioimmunoassay in the basal state and during a 48 hr ACTH infusion. The mean plasma and time-integrated plasma levels of the 3 adrenal androgens in patients with acne were 15-25% higher than normal controls, but the groups were not significantly different (<em>p</em> > .05). The plasma testosterone values, on the other hand, were similar in both groups. In addition, cortisol, 11-deoxycortisol and 17-hydroxyprogesterone basal plasma values and responses to ACTH in patients with acne were similar to the normal control values. These findings suggest that adrenal androgen secretion is at most mildly elevated in patients with idiopathic acne and is unlikely to be the sole cause of acne since many patients without acne have similar hormone levels. Increased sensitivity of the sebaceous gland to androgens or increased local metabolism of androgen hormones in the skin to potent androgen metabolites may offer alternative mechanisms for the pathogenesis of this disorder. [ABSTRACT FROM AUTHOR]
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KW  - ANDROGENS
KW  - ACNE
KW  - RADIOIMMUNOASSAY
KW  - TESTOSTERONE
KW  - BLOOD plasma
KW  - SEX hormones
N1  - Accession Number: 12510160; Chrousos, George P. 1 Peck, Gary L. 2 Gross, Earl G. 1 Cutler Jr., Gordon B. 2 Loriaux, D. Lynn 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, NIH, Bethesda, Maryland, U.S.A.  2: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Maryland, U.S.A.; Source Info: Jun82, Vol. 78 Issue 6, p468; Subject Term: ANDROGENS; Subject Term: ACNE; Subject Term: RADIOIMMUNOASSAY; Subject Term: TESTOSTERONE; Subject Term: BLOOD plasma; Subject Term: SEX hormones; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12510160
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wurtz, Robert H.
AU  - Goldberg, Michael E.
AU  - Robinson, David Lee
T1  - Brain Mechanisms of Visual Attention.
JO  - Scientific American
JF  - Scientific American
Y1  - 1982/06//
VL  - 246
IS  - 6
M3  - Article
SP  - 124
EP  - 135
SN  - 00368733
AB  - The article focuses on the mechanism of brain for visual attention. Visual attention indicates the selection of a visual object from the visual field at the expense of other objects. The brain helps the eye to rotate in their sockets so that the analytic power of the fovea is directed toward objects of interest and make visual attention.
KW  - Visual pathways
KW  - Brain function localization
KW  - Visual fields
KW  - Vision
KW  - Interest (Psychology)
KW  - Eye
N1  - Accession Number: 23034050; Wurtz, Robert H. 1; Goldberg, Michael E. 1; Robinson, David Lee 1; Affiliations: 1: Laboratory of Sensorimotor Research, National Eye Institute.; Issue Info: Jun82, Vol. 246 Issue 6, p124; Subject Term: Visual pathways; Subject Term: Brain function localization; Subject Term: Visual fields; Subject Term: Vision; Subject Term: Interest (Psychology); Subject Term: Eye; Number of Pages: 9p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - FISHER, MICHAEL S.
AU  - KRIPKE, MARGARET L.
T1  - Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated Mice.
JO  - Science
JF  - Science
Y1  - 1982/06/04/
VL  - 216
IS  - 4550
M3  - Article
SP  - 1133
EP  - 1134
SN  - 00368075
AB  - Exposure of mice to ultraviolet radiation results in the development of suppressor T lymphocytes in lymphoid organs, followed by the appearance of primary skin cancers. The presence or absence of these suppressor lymphocytes determines whether or not primary cancers will develop in the ultraviolet-irradiated skin. This demonstrates the importance of immunological regulatory pathways in carcinogenesis and provides an example of immunological surveillance. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705635; FISHER, MICHAEL S. 1; KRIPKE, MARGARET L. 1; Affiliations: 1: Cancer Biology Program, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 6/ 4/1982, Vol. 216 Issue 4550, p1133; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - MARIANI, ANDREW P.
T1  - Biplexiform Cells: Ganglion Cells of the Primate Retina That Contact Photoreceptors.
JO  - Science
JF  - Science
Y1  - 1982/06/04/
VL  - 216
IS  - 4550
M3  - Article
SP  - 1134
EP  - 1136
SN  - 00368075
AB  - Golgi-impregnated biplexiform cells of the macaque retina are neurons with cell bodies in the ganglion cell layer, an axon in the nerve fiber layer, and dendrites in the inner plexiform layer that are postsynaptic to amacrine cell processes and bipolar cell axon terminals. In these features they resemble conventional ganglion cells, but they also have processes that arisefrom the main dendritic arborization, extend to the outer plexiform layer, and are postsynaptic to rod photoreceptor terminals as central elements at the ribbon synaptic complex. However, ordinary retinal ganglion cell dendrites ramify in the inner plexiform layer and do not contact photoreceptors. Thus, biplexiform cells represent a previously undescribed class of neuron, part of whose synaptic input could bypass the commonly described interneuron circuitry of the vertebrate retina. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705636; MARIANI, ANDREW P. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 6/ 4/1982, Vol. 216 Issue 4550, p1134; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - GROFFEN, JOHN
AU  - HEISTERKAMP, NORA
AU  - GROSVELD, FRANK
AU  - DE VEN, WIM VAN
AU  - STEPHENSON, J. R.
T1  - Isolation of Human Oncogene Sequences (v-fes Homolog) from a Cosmid Library.
JO  - Science
JF  - Science
Y1  - 1982/06/04/
VL  - 216
IS  - 4550
M3  - Article
SP  - 1136
EP  - 1138
SN  - 00368075
AB  - To define the human homolog (or homologs) of transforming sequences (v-fes gene) common to Gardner (GA) and Snyder Theilen (ST) isolates of feline sarcoma virus (FeSV), a representative library of human lung carcinoma DNA in a cosmid vector system was constructed. Three cosmid clones were isolated containing GAIST FeSV v-fes homologous cellular sequences, within 32- to 42-kilobase cellular inserts representing 56 kilobases of contiguous human cellular DNA. Sequences both homologous to, and colinear with, GA or ST FeSV v-fes are distributed discontinuously over a region of up to 9.5 kilobases and contain a minimum of three regions of nonhomology representing probable introns. A thymidine kinase selection system was used to show that, upon transfection to RAT-2 cells, the human c-fes sequence lacked detectable transforming activity. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705637; GROFFEN, JOHN 1; HEISTERKAMP, NORA 1; GROSVELD, FRANK 2; DE VEN, WIM VAN 3; STEPHENSON, J. R. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Gene Structure and Expression, Medical Research, Council, London NW7 IAA; 3: Carcinogenesis and Intramural Program, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 6/ 4/1982, Vol. 216 Issue 4550, p1136; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BATTELLE, B.-A.
AU  - EVANS, J. A.
AU  - CHAMBERLAIN, S. C.
T1  - Efferent Fibers to Limulus Eyes Synthesize and Release Octopamine.
JO  - Science
JF  - Science
Y1  - 1982/06/11/
VL  - 216
IS  - 4551
M3  - Article
SP  - 1250
EP  - 1252
SN  - 00368075
AB  - Octopamine synthesized in vitro from tyrnrnine by Limulus lateral and ventral eyes was located by light microscopic and electron microscopic autoradiography in efferent fibers which innervate ventral photoreceptors and lateral eye ommatidia. Newly synthesized octopamine was released from efferent fibers in response to depolarization in high concentrations of potassium. We propose that octopamine is a neurotransmitter of efferent fibers that may modulate basic retinal processes such as photoreceptor sensitivity, photomechanical movements, and photoreceptive membrane turnover. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705683; BATTELLE, B.-A. 1; EVANS, J. A. 1; CHAMBERLAIN, S. C. 2; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; 2: Institute for Sensory Research, Syracuse University, Syracuse, New York 13210; Issue Info: 6/11/1982, Vol. 216 Issue 4551, p1250; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
ID  - 84001152
T1  - Heterozygote detection in cystinosis, using leukocytes exposed to cystine dimethyl ester.
AU  - Steinherz, Reuben
AU  - Tietze, Frank
AU  - Triche, Timothy
AU  - Modesti, Andrea
AU  - Gahl, William A.
AU  - Schulman, Joseph D.
AU  - Steinherz, R
AU  - Tietze, F
AU  - Triche, T
AU  - Modesti, A
AU  - Gahl, W A
AU  - Schulman, J D
Y1  - 1982/06/17/
N1  - Accession Number: 84001152. Language: English. Entry Date: In Process. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Cysteine
KW  - Leukocytes -- Metabolism
KW  - Metabolism, Inborn Errors
KW  - Genetic Techniques -- Methods
KW  - Cysteine -- Metabolism
KW  - Male
KW  - Female
KW  - Metabolism, Inborn Errors -- Diagnosis
KW  - Radioisotopes
SP  - 1468
EP  - 1470
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 306
IS  - 24
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - From the Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, the Section on Intermediary Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health. Address reprint requests to Dr. Schulman at Bldg. 10, Rm. 8C429, National Institutes of Health, Bethesda, MD 20205.
U2  - PMID: 7078591.
DO  - 10.1056/NEJM198206173062407
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DB  - rzh
ER  - 

TY  - JOUR
AU  - BURGDORFER, WILLY
AU  - BARBOUR, ALAN G.
AU  - HAYES, STANLEY F.
AU  - BENACH, JORGE L.
AU  - GRUNWALDT, EDGAR
AU  - DAVIS, JEFFREY P.
T1  - Lyme Disease--A Tick-Borne Spirochetosis?
JO  - Science
JF  - Science
Y1  - 1982/06/18/
VL  - 216
IS  - 4552
M3  - Article
SP  - 1317
EP  - 1319
SN  - 00368075
AB  - A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease. Causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. It is suggested that the newly discovered spirochete is involved in the etiology of Lyme disease. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705720; BURGDORFER, WILLY 1; BARBOUR, ALAN G. 2; HAYES, STANLEY F. 3; BENACH, JORGE L. 4,5; GRUNWALDT, EDGAR 6; DAVIS, JEFFREY P. 7; Affiliations: 1: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 2: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories; 3: Rocky Mountain Operations Branch, Rocky Mountain Laboratories; 4: State of New York Department of Health, State University ofNew York, Stony Brook 11794; 5: Department of Pathology, State University of New York, Stony Brook 11794; 6: 44 South Ferry Road Shelter Island, New York 11964; 7: Department of Health and Social Services, Madison, Wisconsin 53701; Issue Info: 6/18/1982, Vol. 216 Issue 4552, p1317; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - RUSHLOW, KEITH E.
AU  - LAUTENBERGER, JAMES A.
AU  - PAPAS, TAKIS S.
AU  - BALUDA, MARCEL A.
AU  - PERBAL, BERNARD
AU  - CHIRIKJIAN, JACK G.
AU  - REDDY, E. PREMKUMAR
T1  - Nucleotide Sequence of the Transforming Gene of Avian Myeloblastosis Virus.
JO  - Science
JF  - Science
Y1  - 1982/06/25/
VL  - 216
IS  - 4553
M3  - Article
SP  - 1421
EP  - 1423
SN  - 00368075
AB  - Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essentialfor leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 armino acids with a molecular weight of approximately 30,000. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705765; RUSHLOW, KEITH E. 1; LAUTENBERGER, JAMES A. 1; PAPAS, TAKIS S. 1; BALUDA, MARCEL A. 2; PERBAL, BERNARD 2; CHIRIKJIAN, JACK G. 3; REDDY, E. PREMKUMAR 4; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Bethesda, Maryland 2020; 2: UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, California 90024; 3: Georgetown Medical Center, Washington, D.C.; 4: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 2020; Issue Info: 6/25/1982, Vol. 216 Issue 4553, p1421; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - STERNBERG, D. E.
AU  - KAMMEN, D. P. VAN
AU  - LERNER, P.
AU  - BUNNEY, W. E.
T1  - Schizophrenia: Dopamine β-Hydroxylase Activity and Treatment Response.
JO  - Science
JF  - Science
Y1  - 1982/06/25/
VL  - 216
IS  - 4553
M3  - Article
SP  - 1423
EP  - 1425
SN  - 00368075
AB  - Cerebrospinal fluid levels of dopamine β-hydroxylase, found to be relatively constant over time in individual patients, were significantly lower in schizophrenic patients who became nonpsychotic during neuroleptic treatment than in those who remained psychotic. Dopamine 3-hydroxylase activity may delineate a subgroup ofpatients who have a dopamine-sensitive brain disorder. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84705766; STERNBERG, D. E. 1; KAMMEN, D. P. VAN 2; LERNER, P. 2; BUNNEY, W. E. 2; Affiliations: 1: Department of Psychiatry, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven 06519; 2: Section on Neuropsychopharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 6/25/1982, Vol. 216 Issue 4553, p1423; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Sutnick, Alton I.
AU  - Saunders, Joseph F.
AU  - Puchkov, Yuri I.
T1  - Cancer Control in India: A Multinational Approach Involving the USA and the USSR.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1982/07//
VL  - 72
IS  - 7
M3  - Article
SP  - 714
EP  - 717
PB  - American Public Health Association
SN  - 00900036
AB  - Based on a long-standing cooperation in medicine and public health between the United States and the Soviet Union, and on the potential contributions to be made by scientists from both of these countries, the World Health Organization invited an American-Soviet collaborative team to recommend a cancer control program for the Government of India. The consultants defined the importance of cancer of the cervix uteri and of the oral cavity, which comprise one-half of India's cancer cases, as the basis for a cancer control program. They recommended incorporation of cancer control functions into the organizational structure of the Ministry of Health as well as specific recommendations in education, prevention, and early detection, diagnosis, treatment, and epidemiologic studies. This mission underscores the value of multinational cooperation on health care problems that are faced in common by the United States, the Soviet Union, and other countries of the world. In addition it serves as a basis for international friendship and understanding in the context of mutually productive activities which may provide a benefit for all nations. [ABSTRACT FROM AUTHOR]
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KW  - PUBLIC health
KW  - MEDICAL care
KW  - CANCER prevention
KW  - CERVICAL cancer
KW  - PREVENTIVE medicine
KW  - SCIENTISTS
KW  - UNITED States
KW  - SOVIET Union
KW  - WORLD Health Organization
N1  - Accession Number: 4950469; Sutnick, Alton I. 1,2 Saunders, Joseph F. 3 Puchkov, Yuri I. 4; Affiliation:  1: Senior Vice President, Health Affairs, 3300 Henry Avenue, Philadelphia, PA 19129  2: Dean, Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, PA 19129  3: Deputy Director, Office of International Affairs, National Cancer Institute, NIH, Bethesda, MD  4: Chief, Department of International Scientific Relations, Cancer Research Center, USSR Academy of Medical Sciences, Moscow; Source Info: Jul1982, Vol. 72 Issue 7, p714; Subject Term: PUBLIC health; Subject Term: MEDICAL care; Subject Term: CANCER prevention; Subject Term: CERVICAL cancer; Subject Term: PREVENTIVE medicine; Subject Term: SCIENTISTS; Subject Term: UNITED States; Subject Term: SOVIET Union; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yanagihara, R. H.
T1  - HLA AND CLINICAL DISORDERS.
JO  - BioScience
JF  - BioScience
Y1  - 1982/07//Jul/Aug1982
VL  - 32
IS  - 7
M3  - Book Review
SP  - 627
EP  - 627
SN  - 00063568
AB  - The article reviews the book "HLA in Endocrine and Metabolic Disorders," edited by Nadir R. Farid.
KW  - HLA histocompatibility antigens
KW  - Nonfiction
KW  - Farid, Nadir R.
KW  - Hla in Endocrine & Metabolic Disorders (Book)
N1  - Accession Number: 28050152; Yanagihara, R. H. 1; Affiliations: 1 : National Institutes of Health National Institute on Aging Gerontology Research Center Baltimore City Hospitals Baltimore, MD 21224;  Source Info: Jul/Aug1982, Vol. 32 Issue 7, p627; Subject Term: HLA histocompatibility antigens; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 525
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DP  - EBSCOhost
DB  - 8gh
ER  - 

TY  - JOUR
AU  - Luster, M. I.
AU  - Dean, J. H.
AU  - Boorman, G. A.
AU  - Dieter, M. P.
AU  - Hayes, H. T.
T1  - Immune functions in methyl and ethyl carbamate treated mice.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/07//
VL  - 49
IS  - 1
M3  - Article
SP  - 223
EP  - 230
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Female B6C3F1 hybrid mice (5-7 weeks of age) were given methyl or ethyl carbamate over a 2 week period and subsequently examined for alterations in various immunological parameters. Exposure to methyl carbamate, a non-carcinogen, did not cause any alterations in the parameters examined. In contrast, exposure to the multipotential carcinogen, ethyl carbamate (urethan) at tumourigenic dosages caused severe myelotoxicity at all dosage levels. Related to the myelotoxicity was a marked depression of natural killer cell activity. Other parameters including susceptibility to tumour cell challenge, humoral immunity, cellular immunity and macrophage function were less affected. These studies indicate that non-toxic, but carcinogenic dosages of urethan, have profound but selective effects on the immune system which can be related to alterations in bone marrow functions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - URETHANE
KW  - CARCINOGENS
KW  - IMMUNE response
KW  - MICE as laboratory animals
KW  - KILLER cells
KW  - BONE marrow
KW  - CELLULAR immunity
N1  - Accession Number: 16253211; Luster, M. I. 1 Dean, J. H. 1 Boorman, G. A. 1 Dieter, M. P. 1 Hayes, H. T. 1; Affiliation:  1: National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.; Source Info: Jul1982, Vol. 49 Issue 1, p223; Subject Term: URETHANE; Subject Term: CARCINOGENS; Subject Term: IMMUNE response; Subject Term: MICE as laboratory animals; Subject Term: KILLER cells; Subject Term: BONE marrow; Subject Term: CELLULAR immunity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Roder, J. C.
AU  - Haliotis, Tina
AU  - Laing, L.
AU  - Kozbor, Danuta
AU  - Rubin, P.
AU  - Pross, H.
AU  - Boxer, L. A.
AU  - White, J. G.
AU  - Fauci, A. S.
AU  - Mostowski, H.
AU  - Matheson, D. S.
T1  - Further studies of natural killer cell function in Chediak-Higashi patients.
JO  - Immunology
JF  - Immunology
Y1  - 1982/07//
VL  - 46
IS  - 3
M3  - Article
SP  - 555
EP  - 560
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Spontaneous natural killer (NK) activity and antibody-dependent cellular cytotoxicity (ADCC) of blood lymphocytes against five human tumour cell lines (K562, Molt-4, HL-60, Chang, Daudi) and three mouse tumour lines (YAC, P815, RBL-5) were ten- to 100-fold lower than normal in six patients with Chediak-Higashi (CH) disease. NK and ADCC were defective at 4 hr, and less so at 18 hr. The NK activity in normals and CH patients was mediated in part by FcR+, E- effector cells. ADCC against human erythrocytes was normal in CH patients, as were lectin-dependent cytolysis and mixed lymphocyte proliferative responses. Phagocytosis of antibody-coated ox erythrocytes was normal in CH patients as well, These observations confirm that the CH syndrome is associated with a profound and selective defect in NK and ADCC activity against tumour cells, whereas other mononuclear cell-mediated functions are normal. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KILLER cells
KW  - CELL-mediated cytotoxicity
KW  - CANCER cells
KW  - IMMUNOCOMPETENT cells
KW  - ANTIGEN-antibody reactions
KW  - IMMUNOLOGY
N1  - Accession Number: 13953455; Roder, J. C. 1 Haliotis, Tina 1 Laing, L. 1 Kozbor, Danuta 1 Rubin, P. 1 Pross, H. 1 Boxer, L. A. 2 White, J. G. 3 Fauci, A. S. 4 Mostowski, H. 4 Matheson, D. S. 5; Affiliation:  1: Queen's University, Kingston, Ontario, Canada  2: Division of Paediatric Hematology-Oncology, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, West Michigan St., Indianapolis, Indiana  3: Department of Paediatrics, University of Minnesota, School of Medicine, Minneapolis, Minnesota  4: Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland  5: Faculty of Medicine, University of Calgary, N.W., Calgary, Alberta, Canada; Source Info: Jul82, Vol. 46 Issue 3, p555; Subject Term: KILLER cells; Subject Term: CELL-mediated cytotoxicity; Subject Term: CANCER cells; Subject Term: IMMUNOCOMPETENT cells; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Abdi, Hamida B.
AU  - Simons, Margaret A.
AU  - Young-Cooper, Glendowlyn O.
AU  - Mage, Rose G.
T1  - Expression of kappa chain allotypes at the cell surface and in serum immunoglobulins of normal and allotype-suppressed heterozygous rabbits.
JO  - Immunology
JF  - Immunology
Y1  - 1982/07//
VL  - 46
IS  - 3
M3  - Article
SP  - 661
EP  - 669
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The kappa light chain allotypes b4 and b5 were measured in the serum and on the surfaces of peripheral blood lymphocytes of normal and allotype-suppressed heterozygous rabbits. Surface immunoglobulins (sIg) were detected by fluorescence microscopy and additional quantitative data were obtained by flow microfluorometry. Although a few b5-suppressed animals had no b5 in serum or on cell surfaces for years, most b5-suppressed and all b4-suppressed animals studied had some cells with sIg of the suppressed type by I year of age. In suppressed animals the level of serum Ig remained depressed throughout life but cells with sIg appeared in disproportionately large numbers. The effect was particularly striking in those animals suppressed for the b4 type. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN allotypes
KW  - RABBITS as laboratory animals
KW  - CELL membranes
KW  - IMMUNOGLOBULINS
KW  - IMMUNOSUPPRESSION
KW  - IMMUNOLOGY
N1  - Accession Number: 13954056; Abdi, Hamida B. 1 Simons, Margaret A. 1 Young-Cooper, Glendowlyn O. 1 Mage, Rose G. 1; Affiliation:  1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul82, Vol. 46 Issue 3, p661; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: RABBITS as laboratory animals; Subject Term: CELL membranes; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNOLOGY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hearing, Vincent J.
AU  - Korner, Ann M.
AU  - Pawelek, John M.
T1  - New Regulators of Melanogenesis Are Associated with Purified Tyrosinase Isozymes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/07//
VL  - 79
IS  - 1
M3  - Article
SP  - 16
EP  - 18
SN  - 0022202X
AB  - Three new regulatory factors in the melanogenesis pathway were recently described: dopachrome conversion factor accelerates the conversion of dopachrome to 5,6-dihydroxyindole; indole conversion factor accelerates the conversion of 5,6-dihydroxyindole into melanin; and indole blocking factor retards the conversion of 5,6- dihydroxyindole into melanin. Exposure of wild-type Cloudman melanoma cells in culture to melanotropin (MSH) removes blocking factor activity and increases indole conversion factor activity. The chemical nature of the factors has not yet been determined. In this report we demonstrate that highly purified isozymes of tyrosinase from C57B1/6N murine hair bulbs and B16 murine melanoma are closely associated with conversion and blocking factor activities. The soluble isozymes T1, T2, and T3 contain blocking factor activity, while isozyme T4, the major tyrosinase species found in melanosomes, contains activity that accelerates melanin formation from dopachrome. The results suggest that melanogenesis is regulated by the association of these different factors with the specific tyrosinase isozymes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOGENESIS
KW  - PHENOL oxidase
KW  - ISOENZYMES
KW  - MSH (Hormone)
KW  - INDOLE
KW  - ANIMAL pigments
N1  - Accession Number: 12510422; Hearing, Vincent J. 1 Korner, Ann M. 2 Pawelek, John M. 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, U.S.A.; Source Info: Jul82, Vol. 79 Issue 1, p16; Subject Term: MELANOGENESIS; Subject Term: PHENOL oxidase; Subject Term: ISOENZYMES; Subject Term: MSH (Hormone); Subject Term: INDOLE; Subject Term: ANIMAL pigments; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12510422
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sauder, Daniel N.
AU  - Carter, Charles S.
AU  - Katz, Stephen I.
AU  - Oppenheim, Joost J.
T1  - Epidermal Cell Production of Thymocyte Activating Factor (ETAF).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/07//
VL  - 79
IS  - 1
M3  - Article
SP  - 34
EP  - 39
SN  - 0022202X
AB  - Since epidermal Langerhans cells share many of the surface marker characteristics and functions of cells of the monocyte-macrophage series, we sought to determine whether Langerhans cells, like macrophages, produce Interleukin 1 (IL-1), formerly called lymphocyte activating factor. Heterogenous suspensions of murine epidermal cells were cultured for 3 days with or without various stimulants and their cell-free supernatants were tested for IL-1 activity in a thymocyte proliferation assay. Significant augmentation of lectin induced thymocyte proliferation was produced by the supernatants of these cultures. However, when epidermal cells were depleted of Langerhans cells by treating with anti-la anti-serum and complement, the supernatants still produced significant augmentation. As the augmenting activity was due to a factor found in the supernatants of epidermal cell suspensions devoid of Langerhans cells the factor is called Epidermal Cell Thymocyte Activating Factor (ETAF). ETAF was produced by unstimulated epidermal cells, but significantly more was produced by epidermal cells that were incubated with phorbol myristic acetate, a low molecular weight tumor promoting agent or muramyl dipeptide, the synthetic analog of the cell wall of mycobacterium smegmatis. ETAF production was reduced by X-irradiation and was completely abolished when protein synthesis was inhibited. The molecular weight of this factor was approximately 15,000 dalton, which is similar to the molecular weight of macrophage derived IL-1; its heat stability and pH stability were similar to that of IL-1. ETAF, like IL-1 also enhanced lymphocyte production of Interleukin 2 (IL-2). The data indicate that epidermal cells, devoid of Langerhans cells, are capable of producing factors with IL-1 like activity and may thereby modulate immune responses locally in the skin and perhaps systemically. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - EPIDERMAL growth factor
KW  - CELL surface antigens
KW  - MACROPHAGES
KW  - INTERLEUKIN-1
KW  - CELL suspensions
KW  - MYCOBACTERIUM
N1  - Accession Number: 12510569; Sauder, Daniel N. 1,2 Carter, Charles S. 1,2 Katz, Stephen I. 1,2 Oppenheim, Joost J. 1,2; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul82, Vol. 79 Issue 1, p34; Subject Term: LANGERHANS cells; Subject Term: EPIDERMAL growth factor; Subject Term: CELL surface antigens; Subject Term: MACROPHAGES; Subject Term: INTERLEUKIN-1; Subject Term: CELL suspensions; Subject Term: MYCOBACTERIUM; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12510569
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Garwood, M.
AU  - Engel, B. T.
AU  - Caprioiti, R.
T1  - Autonomic Nervous System Function and Aging: Response Specificity.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1982/07//
VL  - 19
IS  - 4
M3  - Article
SP  - 378
EP  - 385
SN  - 00485772
AB  - Age differences in autonomic nervous system response patterns were investigated to determine if there was an age-related increase in the tendency to respond to multiple stimuli with a consistent response hierarchy (individual consistency). Five stimuli were administered in a Latin Square design-mental arithmetic, cold pressor, isometric exercise, comic slide, and time estimation. A warning tone was presented before each stimulus. Physiological measures included heart rate, systolic and diastolic blood pressures, skin potential, breathing rate, and digital blood flow. To compare responses in different systems, responses were standardized according to the formula, Z = [50 + 10(X - M)]/σ, where Z is the standardized score, X is the difference between stimulation and warning levels, M is the avenge response for that system, and σ is the square root of the mean square for error from the analysis of variance computed for each response system. A matrix was generated lot each subject which Included his Z scores from the six response systems for the five stimuli. Intraclass correlations were then computed. Individual consistency significantly Increased with increasing age (<em>r</em> = .33, <em>p</em><.005). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTONOMIC nervous system
KW  - AGING
KW  - MENTAL arithmetic
KW  - TIME perception
KW  - HEART beat
KW  - BLOOD pressure
KW  - Aging
KW  - Autonomic nervous system
KW  - Response specificity
N1  - Accession Number: 14180133; Garwood, M. 1 Engel, B. T. 2 Caprioiti, R. 3; Affiliation:  1: Gerontology Research Center (Baltimore), National Institute on Aging.  2: Baltimore City Hospital, Baltimore.  3: National Institutes of Health, PHS, U. S. Department of Human Health Services, Bethesda.; Source Info: Jul1982, Vol. 19 Issue 4, p378; Subject Term: AUTONOMIC nervous system; Subject Term: AGING; Subject Term: MENTAL arithmetic; Subject Term: TIME perception; Subject Term: HEART beat; Subject Term: BLOOD pressure; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Autonomic nervous system; Author-Supplied Keyword: Response specificity; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-8986.ep14180133
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levy, Robert I.
AU  - Moskowitz, Jay
T1  - Cardiovascular Research: Decades of Progress, a Decade of Promise.
JO  - Science
JF  - Science
Y1  - 1982/07/09/
VL  - 217
IS  - 4555
M3  - Article
SP  - 121
EP  - 129
SN  - 00368075
AB  - Mortality due to cardiovascular diseases has decreased more than 30 percent in the last 30 years, and this decline has accelerated so much that over 60 percent of it has occurred between 1970 and 1980. The past and present contributions of advances in cardiovascular research to this decline are reviewed. Although there have been significant research accomplishments, too many people still die of heart and blood vessel diseases. Continued emphasis must be placed on research in the areas of etiology and pathogenesis, on validating potentially beneficial research hypotheses, and on the translation and dissemination of research results to the health care practitioner and the public. Only then can our long-term goal, the prevention of cardiovascular disease, be fully realized. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88017027; Levy, Robert I. 1; Moskowitz, Jay 2; Affiliations: 1: Vice President for Health Sciences, Tufts University, Boston, Massachusetts 02111; 2: Associate Director for Scientific Program Operation, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 7/ 9/1982, Vol. 217 Issue 4555, p121; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Tolstoshev, Paul
AU  - Crystal, Ronald G.
T1  - The Collagen Alpha-2 Chain Gene.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/07/15/
VL  - 79
M3  - Article
SP  - 60s
EP  - 64s
SN  - 0022202X
AB  - A number of DNA sequences specific for collagen messenger RNAs and genes have been isolated, cloned in bacterial plasmids or bacteriophage, and studied in detail. Such sequences have been used to study regulatory mechanisms underlying the production of type I collagen in fibroblasts in culture, fibroblasts after viral transformation, and in tissues and organs during embryonic and fetal development. It is clear that a variety of mechanisms, transcriptional, translational and post-translational, are used by cells to regulate collagen production. The study of isolated collagen gene fragments coding for the α2 collagen chain in sheep and chick have shown that these genes are very large, and are interrupted by as many as 50 intervening sequences. Additionally, the structure of the genes in the regions coding for the helical regions of the protein provides evidence that collagen genes may have arisen from the reduplication of a DNA segment containing a primordial collagen gene sequence. The availability of specific cloned collagen gene sequences will allow the precise chromosomal location of the collagen genes as well as the number and the linkage relationships between these genes, in addition, genetic disorders of connective tissue where alterations in collagen structure are implicated will now be amenable to analysis at the DNA level. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLLAGEN
KW  - GENES
KW  - NUCLEOTIDE sequence
KW  - MESSENGER RNA
KW  - BACTERIOPHAGES
KW  - GENETIC disorders
N1  - Accession Number: 12545778; Tolstoshev, Paul 1 Crystal, Ronald G. 1; Affiliation:  1: Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesada, Maryland, U. S. A.; Source Info: Jul82Supplement, Vol. 79, p60s; Subject Term: COLLAGEN; Subject Term: GENES; Subject Term: NUCLEOTIDE sequence; Subject Term: MESSENGER RNA; Subject Term: BACTERIOPHAGES; Subject Term: GENETIC disorders; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12545778
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Woodley, David T.
AU  - Katz, Stephen I.
AU  - Martin, George R.
T1  - Structure and Function of Basement Membrane.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/07/15/
VL  - 79
M3  - Article
SP  - 69s
EP  - 72s
SN  - 0022202X
AB  - Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen. Basement membrane contains a unique collagen, type IV collagen, which is formed of pro α1(IV) (Mr185,000) and pro α2(IV) (Mr 170,000) chains. As opposed to the fibrillar pattern seen with other collagens, the type IV collagen molecules are thought to be arranged in a honey-comb or reticular pattern which provides the major structural element of the basement membrane. Consistent with this model, type IV collagen has been localized to the basement membrane lamina densa, a nonfibrillar structure. Laminin is a large (Mr= 1,000,000) noncollagenous glycoprotein with chains of 200,000 and 400,000 daltons. It has been localized to the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. A heparan sulfate proteoglycan has also been identified in the basement membrane. Its biological function may be to restrict the penetration of anionic macromolecules through the basement membrane. In contrast to the above-mentioned components which are found in all tissue basement membranes, bullous pemphigoid antigen is only found in certain basement membranes, mostly those of stratified squamous epithelia. Bullous pemphigoid antigen is a protein, synthesized by keratinocytes in culture, with disulfide-linked chains (Mr=220,000). By immunoelectron microscopy, it is localized in the lamina lucida of epidermal basement membrane and is closely associated with the basal cell surface. Its biological function is not known, but could involve epidermal basal cell-substrate interactions which occur when basal cells re-epithelialize wounds. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL lamina
KW  - COLLAGEN
KW  - ANTIGENS
KW  - EPITHELIUM
KW  - PROTEOGLYCANS
KW  - GLYCOPROTEINS
N1  - Accession Number: 12545830; Stanley, John R. 1 Woodley, David T. 2 Katz, Stephen I. 3 Martin, George R. 2; Affiliation:  1: Department of Dermatology, Uniformed Services University of Health Sciences, Bethesda, Maryland.  2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.  3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul82Supplement, Vol. 79, p69s; Subject Term: BASAL lamina; Subject Term: COLLAGEN; Subject Term: ANTIGENS; Subject Term: EPITHELIUM; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12545830
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ER  - 

TY  - JOUR
AU  - Rennard, Stephen I.
AU  - Stier, Larue E.
AU  - Crystal, Ronald G.
T1  - Intracellular Degradation of Newly Synthesized Collagen.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1982/07/15/
VL  - 79
M3  - Article
SP  - 77s
EP  - 82s
SN  - 0022202X
AB  - The in intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy. [ABSTRACT FROM AUTHOR]
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KW  - COLLAGEN
KW  - EXTRACELLULAR matrix proteins
KW  - DIABETES
KW  - CONNECTIVE tissues
KW  - SCURVY
KW  - EXTRACELLULAR matrix
N1  - Accession Number: 12545844; Rennard, Stephen I. 1 Stier, Larue E. 1 Crystal, Ronald G. 1; Affiliation:  1: Pulmonary Branch, National Heart, Lung and Blood Institute Bethesda, Maryland, U.S.A.; Source Info: Jul82Supplement, Vol. 79, p77s; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: DIABETES; Subject Term: CONNECTIVE tissues; Subject Term: SCURVY; Subject Term: EXTRACELLULAR matrix; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12545844
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TY  - JOUR
AU  - TRIGG, MICHAEL E.
AU  - POPLACK, DAVID G.
T1  - Transplantation of Leukemic Bone Marrow Treated with Cytotoxic Antileukemic Antibodies and Complement.
JO  - Science
JF  - Science
Y1  - 1982/07/16/
VL  - 217
IS  - 4556
M3  - Article
SP  - 259
EP  - 261
SN  - 00368075
AB  - The ability of antiserum against murine L1210 leukemia to remove residual leukemia cells from murine bone marrow was investigated. Leukemic marrow was treated in vitro with antiserum and complement and used to hematologically reconstitute mice that had been irradiated with doses lethal to bone marrow. Following infusion of treated leukemic marrow, normal marrow returned without evidence of leukemia. More than 90 percent of the animals have survived for 11 months without untoward effects, suggesting that the technique may be of use in the treatment of acute leukemia in humans. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003741; TRIGG, MICHAEL E. 1; POPLACK, DAVID G. 2; Affiliations: 1: Department of Pediatrics, University of Wisconsin, Madison 53792; 2: Pediatric Oncology Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 7/16/1982, Vol. 217 Issue 4556, p259; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - NESTLER, ERIC J.
AU  - ZATZ, MARTIN
AU  - GREENGARD, PAUL
T1  - A Diurnal Rhythm in Pineal Protein 1 Content Mediated by ß-Adrenergic Neurotransmission.
JO  - Science
JF  - Science
Y1  - 1982/07/23/
VL  - 217
IS  - 4557
M3  - Article
SP  - 357
EP  - 359
SN  - 00368075
AB  - A diurnal rhythm was found in the total amount of the neuron-specific phosphoprotein protein I in rat pinealocytes. ß-Adrenergic neurotransmission appears to be the mechanism regulating the amount of pineal protein I in vivo. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712020; NESTLER, ERIC J. 1; ZATZ, MARTIN 2; GREENGARD, PAUL 3; Affiliations: 1: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Department of Pharmacology, Yale University School of Medicine; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p357; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - TALMADGE, JAMES E.
AU  - WOLMAN, SANDRA R.
AU  - FIDLER, ISAIAH J.
T1  - Evidence for the Clonal Origin of Spontaneous Metastases.
JO  - Science
JF  - Science
Y1  - 1982/07/23/
VL  - 217
IS  - 4557
M3  - Article
SP  - 361
EP  - 363
SN  - 00368075
AB  - A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastdses were isolated from different animals, established in culture as individual lines, and then karyotyped. Within -certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the tells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712022; TALMADGE, JAMES E. 1; WOLMAN, SANDRA R. 2; FIDLER, ISAIAH J. 3; Affiliations: 1: Cancer Metastasis, Treatment Laboratory, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; 2: New York University Medical Center, Department of Pathology, School of Medicine, New York 10016; 3: Cancer Metastasis and Treatment Laboratory, National Cancer Institute, Frederick Cancer Research Facility; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p361; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - HANNA JR., MICHAEL G.
AU  - KEY, MARC E.
T1  - Immunotherapy of Metastases Enhances Subsequent Chemotherapy.
JO  - Science
JF  - Science
Y1  - 1982/07/23/
VL  - 217
IS  - 4557
M3  - Article
SP  - 367
EP  - 369
SN  - 00368075
AB  - In many multimodal therapies of cancer, postsurgical chemotherapy is administered before immunotherapy for treatment of micrometastatic disease. This sequence may not be the most efficacious. Experiments in which strain 2 guinea pigs bearing syngeneic L1O hepatocarcinomas were given immunotherapy showed that infiltrating immune effector cells not only were tumoricidal but disrupted the characteristically compact structure of metastatic foci. When cytotoxic drugs were administered at the peak of this inflammatory response, the survival rate of the guinea pigs increased significantly. We conclude that postsurgical immunotherapy can enhance the effect of cytotoxic drugs administered subsequently. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712026; HANNA JR., MICHAEL G. 1; KEY, MARC E. 1; Affiliations: 1: Cancer Metastasis, Treatment Laboratory, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p367; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - PEARSON, RICHARD D.
AU  - MANIAN, ALBERT A.
AU  - HARCUS, JANE L.
AU  - HALL, DENNIS
AU  - HEWLETT, ERIK L.
T1  - Lethal Effect of Phenothiazine Neuroleptics on the Pathogenic Protozoan Leishmania donovani.
JO  - Science
JF  - Science
Y1  - 1982/07/23/
VL  - 217
IS  - 4557
M3  - Article
SP  - 369
EP  - 371
SN  - 00368075
AB  - Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have beenfound to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sandfly, and the intracellular stage, which is found solely in human macrophages during established infection. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712027; PEARSON, RICHARD D. 1; MANIAN, ALBERT A. 2; HARCUS, JANE L. 3; HALL, DENNIS 3; HEWLETT, ERIK L. 3; Affiliations: 1: Department of Medicine, Division of Geographic Medicine, University of Virginia School of Medicine, Charlottesville 22908; 2: Neurosciences Research Branch, National Institute of Mental Health, Rockville, Maryland 20857; 3: Department of Medicine, Division of Geographic Medicine, University of Virginia School of Medicine; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p369; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - WYSOR, MICHAEL S.
AU  - ZWELLING, LEONARD A.
AU  - SANDERS, JAMES E.
AU  - GRENAN, MARIE M.
T1  - Cure of Mice Infected with Trypanosoma rhodesiense by cis-Diamminedichloroplatinum (II) and Disulfiram Rescue.
JO  - Science
JF  - Science
Y1  - 1982/07/30/
VL  - 217
IS  - 4558
M3  - Article
SP  - 454
EP  - 456
SN  - 00368075
AB  - Mice infected with Trypanosoma rhodesiense were treated concurrently with cis-diamminedichloroplatinum (HI) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice. The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003781; WYSOR, MICHAEL S. 1; ZWELLING, LEONARD A. 2; SANDERS, JAMES E. 3; GRENAN, MARIE M. 4; Affiliations: 1: Department of Parasitology, Walter Reed Army Institute of Research, Washington, D.C. 20012; 2: Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Pathology, Walter Reed Army Institute of Research; 4: Department of Parasitology, Walter Reed Army Institute of Research; Issue Info: 7/30/1982, Vol. 217 Issue 4558, p454; Number of Pages: 3p; Document Type: Article
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TY  - JOUR
AU  - CARPER, DEBORAH
AU  - SHINOHARA, TOSHIMICHI
AU  - PIATIGORSKY, JORAM
AU  - KINOSHITA, JIN H.
T1  - Deficiency of Functional Messenger RNA for a Developmentally Regulated, β-Crystallin Polypeptide in a Hereditary Cataract.
JO  - Science
JF  - Science
Y1  - 1982/07/30/
VL  - 217
IS  - 4558
M3  - Article
SP  - 463
EP  - 464
SN  - 00368075
AB  - The messenger RNA for a β-crystallin polypeptide with a molecular size of 27 kilodaltons, first detected 5 to 10 days after birth in the normal mouse lens and the Nakano mouse cataract, was not detected in the Philly mouse cataract with translation in vitro. The heterozygous Philly lens had intermediate levels of the 27- kilodalton β-crystallin polypeptide and exhibited delayed onset of the cataract. The deficiency of functional 27-kilodalton P-crystallin messenger RNA is the earliest lesion reported yet for the Philly lens and points to a transcriptional or posttranscriptional developmental defect in this hereditary cataract. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003785; CARPER, DEBORAH 1; SHINOHARA, TOSHIMICHI 2; PIATIGORSKY, JORAM 2; KINOSHITA, JIN H. 3; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health; 3: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; Issue Info: 7/30/1982, Vol. 217 Issue 4558, p463; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Tsokos, G. C.
AU  - Rook, A. H.
AU  - Djeu, Julie Y.
AU  - Balow, J. E.
T1  - Natural killer cells and interferon responses in patients with systemic lupus erythematosus.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/08//
VL  - 49
IS  - 2
M3  - Article
SP  - 239
EP  - 245
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Natural killer (NK) cell activity was studied in 23 patients with systemic lupus erythematosus (SLE), The overall NK activity was lower in patients with SLE than in normal female individuals. Patients with clinically active SLE disease had slightly lower NK activity than the patients with inactive disease. Other clinical parameters as well as treatment status did not correlate with NK activity. Interferon (IFN) enhanced the NK activity of normal individuals and of 11 SLE patients, while it did not enhance in the remaining 12 patients. The patients whose NK activity was enhanced by β/IFN had significantly higher initial activity than those who did not respond to β/IFN. Furthermore, peripheral mononuclear cells (MNC) from IFN responders produced γ-IFN after stimulation with concanavalin A (Con A) in titres comparable to those of normals. In contrast, peripheral MNC from β-IFN non-responders failed to produce significant titres of γ-IFN after stimulation with Con A. These results indicate that certain patients with SLE have low NK activity, which is generally paralleled by an inability to respond to exogenous β-IFN and by blunted production of γ-IFN after stimulation with Con A. [ABSTRACT FROM AUTHOR]
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KW  - KILLER cells
KW  - SYSTEMIC lupus erythematosus
KW  - INTERFERONS
KW  - COLLAGEN diseases
KW  - IMMUNOCOMPETENT cells
KW  - AUTOIMMUNE diseases
N1  - Accession Number: 16252893; Tsokos, G. C. 1 Rook, A. H. 1 Djeu, Julie Y. 1 Balow, J. E. 1; Affiliation:  1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health and Division of Virology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, USA.; Source Info: Aug1982, Vol. 49 Issue 2, p239; Subject Term: KILLER cells; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: INTERFERONS; Subject Term: COLLAGEN diseases; Subject Term: IMMUNOCOMPETENT cells; Subject Term: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Hofstetter, M.
AU  - Poindexter, R. W.
AU  - Ruiz-Tiben, E.
AU  - Ottesen, E.A.
T1  - Modulation of the host response in human schistosomiasis II. BLOCKING ANTIBODIES SPECIFICALLY INHIBIT IMMEDIATE HYPERSENSITIVITY RESPONSES TO PARASITE ANTIGENS.
JO  - Immunology
JF  - Immunology
Y1  - 1982/08//
VL  - 46
IS  - 4
M3  - Article
SP  - 777
EP  - 785
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Mechanisms for modulating the host's immune response in human Schistosomiasis mansoni have been described for delayed hypersensitivity responsiveness and antibody production. Since clinical symptoms of immediate hypersensitivity (i.e. allergic reactivity) are rare in schistosomiasis despite the presence of parasite-specific immunoglobulin E, circulating parasite antigen, and normal numbers of basophils and mast cells in infected patients, it seemed likely that there was host modulation of immediate hypersensitivity responsiveness as well. Using an in vitro basophil histamine release assay we have shown that basophils from fifteen patients with S. mansoni infections are sensitized with schistosome-specific immunoglobulin E and will release histamine in an antigen-dose-dependent manner when challenged with a soluble adult worm antigen. This histamine release was suppressed by autologus, but not normal serum. Fractionation of the serum over staphylococcal protein A and antigen affinity columns identified an immunoglobulin G parasite-specific 'blocking antibody', analogous to blocking antibodies elicited during immunotherapy of atopic patients, as being responsible for the modulation of this immediate hypersensitivity responsiveness in vitro. Blocking antibody specificity varied from patient to patient, an observation suggesting that different allergens were being recognized by different individuals. These studies demonstrate that in addition to the immunoregulatory mechanisms previously described in patients with schistosome infections, there is host modulation of immediate hypersensitivity responsiveness that appears to involve specific immunoglobulin G blocking antibodies. [ABSTRACT FROM AUTHOR]
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KW  - IMMUNE response
KW  - SCHISTOSOMIASIS
KW  - HELMINTHIASIS
KW  - IMMUNOGLOBULIN E
KW  - PARASITE antigens
KW  - BASOPHILS
KW  - MAST cells
N1  - Accession Number: 13935715; Hofstetter, M. 1 Poindexter, R. W. 1 Ruiz-Tiben, E. 2 Ottesen, E.A. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA  2: San Juan Laboratories, Center for Infectious Diseases, Centers for Disease Control, San Juan, Puerto Rico; Source Info: Aug82, Vol. 46 Issue 4, p777; Subject Term: IMMUNE response; Subject Term: SCHISTOSOMIASIS; Subject Term: HELMINTHIASIS; Subject Term: IMMUNOGLOBULIN E; Subject Term: PARASITE antigens; Subject Term: BASOPHILS; Subject Term: MAST cells; Number of Pages: 9p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - EPSTEIN, SUZANNE
AU  - NADLER, PAUL
AU  - LUNNEY, JOAN
T1  - Multiple Submission.
JO  - Science
JF  - Science
Y1  - 1982/08/20/
VL  - 217
IS  - 4561
M3  - Article
SP  - 686
EP  - 686
SN  - 00368075
N1  - Accession Number: 84705862; EPSTEIN, SUZANNE 1; NADLER, PAUL 1; LUNNEY, JOAN 1; Affiliations: 1: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 8/20/1982, Vol. 217 Issue 4561, p686; Number of Pages: 1/4p; Document Type: Article
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TY  - JOUR
AU  - Hankin, Janet R.
AU  - Locke, Ben Z.
T1  - The Persistence of Depressive Symptomatology among Prepaid Group Practice Enrollees: An Exploratory Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1982/09//
VL  - 72
IS  - 9
M3  - Article
SP  - 1000
EP  - 1007
PB  - American Public Health Association
SN  - 00900036
AB  - This exploratory study examines the persistence of depressive symptomatology as measured by the Center for Epidemiologic. Studies Depression Scale (CES-D) Over a 12-month period, half of a group of 309 prepaid group practice enrollees reporting depressive symptoms at the beginning of the interval also had high scores on the CES-D at the end of the interval. Sociodemographic characteristics did not predict persistence of depression. Persistence of depression was positively associated with initially reporting cognitive and affective types of depressive symptoms, the presence of physical illness, the seeking of psychiatric treatment, and the receipt of psychotropic drug prescriptions. (Am J Public Health 1982: 72: 1000-1007. ) [ABSTRACT FROM AUTHOR]
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KW  - MENTAL depression
KW  - SYMPTOMS
KW  - SOCIODEMOGRAPHIC factors
KW  - PSYCHIATRY
KW  - PSYCHIATRIC drugs
N1  - Accession Number: 4949328; Hankin, Janet R. 1 Locke, Ben Z. 2; Affiliation:  1: Center for Metropolitan Planning and Research, Shriver Hall, Johns Hopkins University, Baltimore, MD 21218  2: National Institute of Mental Health; Source Info: Sep82, Vol. 72 Issue 9, p1000; Subject Term: MENTAL depression; Subject Term: SYMPTOMS; Subject Term: SOCIODEMOGRAPHIC factors; Subject Term: PSYCHIATRY; Subject Term: PSYCHIATRIC drugs; Number of Pages: 8p; Document Type: Article
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TY  - JOUR
AU  - Tsokos, G. C.
AU  - Christian, Carole B.
AU  - Balow, J. E.
T1  - Concanavalin-induced suppressor cells: characterization on the basis of corticosteroid and radiation sensitivity.
JO  - Immunology
JF  - Immunology
Y1  - 1982/09//
VL  - 47
IS  - 1
M3  - Article
SP  - 85
EP  - 90
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Experiments were performed to examine whether the concanavalin A (Con A)- induced suppressor cells of several in vitro T- and B-lymphocyte functions constitute a functionally unique cell population. This study included simultaneous studies of three different assays of suppression of T- and B-lymphocyte functions. We found that Con-A-induced suppressor cells which inhibit the allogeneic mixed lymphocyte reaction (MLR) and the pokeweed mitogen-induced, plaque-forming cell (PFC) response are radiation sensitive at doses greater than 1000 rad, but corticosteroid resistant, while those suppressing allogeneic cell-mediated lympholysis (CML) are both radiation and corticosteroid resistant. These studies indicate either that Con-A-induced suppressor cells include heterogeneous populations which are differentially sensitive to corticosteroids and radiation, or that functionally distinct suppressor mechanisms are variably sensitive to these agents. [ABSTRACT FROM AUTHOR]
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KW  - SUPPRESSOR cells
KW  - T cells
KW  - IMMUNOSUPPRESSION
KW  - IMMUNE response
KW  - IMMUNOLOGY
KW  - B cells
KW  - ADRENOCORTICAL hormones
N1  - Accession Number: 13936376; Tsokos, G. C. 1 Christian, Carole B. 1 Balow, J. E. 1; Affiliation:  1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases; National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep82, Vol. 47 Issue 1, p85; Subject Term: SUPPRESSOR cells; Subject Term: T cells; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: B cells; Subject Term: ADRENOCORTICAL hormones; Number of Pages: 6p; Document Type: Article
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TY  - JOUR
AU  - DHAR, RAVI
AU  - ELLIS, RONALD W.
AU  - SHIH, THOMAS Y.
AU  - OROSZLAN, STEPHEN
AU  - SHAPIRO, BRUCE
AU  - MAIZEL, JACOB
AU  - LowY, DOUGLAS
AU  - SCOLNICK, EDWARD
T1  - Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1982/09/03/
VL  - 217
IS  - 4563
M3  - Article
SP  - 934
EP  - 937
SN  - 00368075
AB  - Harvey murine sarcoma virus is a retrovirus which transforms cells by means of a single virally encoded protein called p21 has. We have determined the nucleotide sequence of 1.0 kilobase in the 5' half of the viral genome which encompasses the has coding sequences and its associated regulatory signals. The nucleotide sequence has identified the amino acid sequence of two additional overlapping polypeptides which share their reading frames and the carboxyl termini with p21 but which contain additional NH2-terminal amino acids. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712065; DHAR, RAVI 1; ELLIS, RONALD W. 2; SHIH, THOMAS Y. 2; OROSZLAN, STEPHEN 3; SHAPIRO, BRUCE 4; MAIZEL, JACOB 5; LowY, DOUGLAS 6; SCOLNICK, EDWARD 2; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Laboratory of Tumor Virus Genetics, National Cancer Institute; 3: Biological Carcinogenesis Program, Frederick Cancer Research Facility, Frederick, Maryland 21701; 4: Laboratory of Pathology, Image Processing Section, National Cancer Institute; 5: Laboratory of Molecular Genetics, National Institute of Child Health and Development, Bethesda, Maryland 20205; 6: Laboratory of Dermatology, National Cancer Institute; Issue Info: 9/ 3/1982, Vol. 217 Issue 4563, p934; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Takahashi, Joseph S.
AU  - Zatz, Martin
T1  - Regulation of Circadian Rhythmicity.
JO  - Science
JF  - Science
Y1  - 1982/09/17/
VL  - 217
IS  - 4565
M3  - Article
SP  - 1104
EP  - 1111
SN  - 00368075
N1  - Accession Number: 84712081; Takahashi, Joseph S. 1,2; Zatz, Martin 1; Affiliations: 1: Members, Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Phannacology Research Associate, National Institute of General Medical Sciences, Bethesda, Maryland 20205; Issue Info: 9/17/1982, Vol. 217 Issue 4565, p1104; Number of Pages: 8p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - BENVENISTE, RAOUL E.
AU  - TODARO, GEORGE J.
AU  - LESLIE, CRYSTAL A.
AU  - WALD, GEORGE
AU  - GELLHORN, ALFRED
AU  - ELIOT JR., THEODORE L.
AU  - DERSHOWITZ, ALAN M.
AU  - POLLACK, HERMAN
T1  - Gene Transfer Between Eukaryotes.
JO  - Science
JF  - Science
Y1  - 1982/09/24/
VL  - 217
IS  - 4566
M3  - Article
SP  - 1202
EP  - 1204
SN  - 00368075
N1  - Accession Number: 88003872; BENVENISTE, RAOUL E. 1; TODARO, GEORGE J. 1; LESLIE, CRYSTAL A. 2; WALD, GEORGE 3,4; GELLHORN, ALFRED 5; ELIOT JR., THEODORE L. 6; DERSHOWITZ, ALAN M. 7; POLLACK, HERMAN 8; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118; 3: Marine Biological Laboratory, Woods Hole, Massachusetts 02543; 4: Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138; 5: Department of Health, Policy, and Management, Graduate School of Public Health, Harvard University, Boston, Massachusetts 02115; 6: Fletcher School of Law and Diplomacy, Tufts University, Medford, Massachusetts 02155; 7: Harvard Law School, Cambridge, Massachusetts 02138; 8: AAAS Committee on Scientific Freedom and Responsibility, 1515 Massachusetts Avenue, NW, Washington, D.C. 20005; Issue Info: 9/24/1982, Vol. 217 Issue 4566, p1202; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - GAHL, W. A.
AU  - BASHAN, N.
AU  - TIETZE, F.
AU  - BERNARDINI, I.
AU  - SCHULMAN, J. D.
T1  - Cystine Transport Is Defective in Isolated Leukocyte Lysosomes from Patients with Cystinosis.
JO  - Science
JF  - Science
Y1  - 1982/09/24/
VL  - 217
IS  - 4566
M3  - Article
SP  - 1263
EP  - 1265
SN  - 00368075
AB  - The activity of a cystine transport system in lysosomes prepared from the leukocytes of patients with cystinosis was found to be deficient. In normal subjects, this system was resistant to N-ethylmaleimide and demonstrated saturation kinetics. Lysosomes from individuals heterozygous for cystinosis demonstrated a reduced maximum velocity for cystine egress from lysosomes. The rate of cystine escape from normal lysosomes was enhanced by adenosine triphosphate. The availability of normal and mutant lysosomes provides a means of investigating mechanisms of amino acid transport across lysosomal membranes. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003908; GAHL, W. A. 1; BASHAN, N. 1; TIETZE, F. 2; BERNARDINI, I. 1; SCHULMAN, J. D. 1; Affiliations: 1: Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Section on Intermediary Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 9/24/1982, Vol. 217 Issue 4566, p1263; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - ZELENKA, PEGGY S.
AU  - BEEBE, DAVID C.
AU  - FEAGANS, DOUGLAS E.
T1  - Transmethylation of Phosphatidylethanolamine: An Initial Event in Embryonic Chicken Lens Fiber Cell Differentiation.
JO  - Science
JF  - Science
Y1  - 1982/09/24/
VL  - 217
IS  - 4566
M3  - Article
SP  - 1265
EP  - 1267
SN  - 00368075
AB  - Agents that induce differentiation of lens epithelial cells into lens fiber cells in vitro transiently stimulate the transmethylation of phosphatidylethanolamine. Inhibition of transmethylation by 3-deazaadenosine results in a corresponding inhibition of the cell elongation that characterizes lens fiberformation, suggesting that phospholipid methylation plays an essential role in the differentiation of these cells. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 88003909; ZELENKA, PEGGY S. 1; BEEBE, DAVID C. 2; FEAGANS, DOUGLAS E. 2; Affiliations: 1: Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814; Issue Info: 9/24/1982, Vol. 217 Issue 4566, p1265; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Earp, Jo Anne L.
AU  - Ory, Marcia G.
AU  - Strogatz, Davrd S.
T1  - The Effects of Family Involvement and Practitioner Home Visits on the Control of Hypertension.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1982/10//
VL  - 72
IS  - 10
M3  - Article
SP  - 1146
PB  - American Public Health Association
SN  - 00900036
AB  - The effectiveness of two social support strategies designed to lower hypertensive patients' blood pressure were compared to each other and to a control group (N = 63) receiving routine care in a randomized clinical trial extending over a period of two years. Group 1 (N = 99) received visits and had family members actively participate in their care through home blood pressure monitoring; Group 2 (N = 56) received home visits from nurses and pharmacists. All groups were predominantly Black. After the first year of the trial, the proportion of patients with uncontrolled diastolic blood pressure (≥95mm Hg) had declined significantly for all three groups; no group showed a statistically significant advantage. However, during the last six months of the second year (after visiting had ended), both Groups 1 and 2 demonstrated clear superiority in DBP control over Group 3, achieving borderline statistical significance (p = .07) when multivariable analysis was performed to control for potential confounders. Supplementing routine care with periodic home visits produced an additional 21 per cent of patients with well-controlled DSP, while involving family members plus visits produced a 17 per cent improvement in the percentage of patients with DSP < 95mm Hg. However, neither support strategy was clearly more effective than the other over time. The efficacy of the interventions is discussed with respect to cost and feasibility of implementation. [ABSTRACT FROM AUTHOR]
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KW  - HYPERTENSION
KW  - SOCIAL support
KW  - SOCIAL services
KW  - BLOOD pressure measurement
KW  - FRIENDLY visiting
KW  - MEDICAL social work
KW  - BLOOD circulation disorders
KW  - CARDIOVASCULAR diseases
KW  - MEDICAL care
KW  - PUBLIC health -- United States
N1  - Accession Number: 4952315; Earp, Jo Anne L. 1 Ory, Marcia G. 2 Strogatz, Davrd S. 3; Affiliation:  1: Department of Health Education, School of Public Health, University of North Carolina, Chapel Hill, NC 27514.  2: Social and Behavioral Research, National Institute of Aging, NIH  3: Department of Epidemiology. UNCSPH.; Source Info: Oct82, Vol. 72 Issue 10, p1146; Subject Term: HYPERTENSION; Subject Term: SOCIAL support; Subject Term: SOCIAL services; Subject Term: BLOOD pressure measurement; Subject Term: FRIENDLY visiting; Subject Term: MEDICAL social work; Subject Term: BLOOD circulation disorders; Subject Term: CARDIOVASCULAR diseases; Subject Term: MEDICAL care; Subject Term: PUBLIC health -- United States; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 9p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Nagel, J. E.
AU  - Chrest, F. J.
AU  - Adler, W. H.
T1  - Mitogenic activity of 12-0-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1982/10//
VL  - 50
IS  - 1
M3  - Article
SP  - 217
EP  - 224
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The effect of age on the proliferative response to 12-O-tetradecanoyl phorbol-13-acetate (TPA) was examined using peripheral blood lymphocytes from 185 adults. TPA-induced DNA synthesis measured by cellular 3H-thymidine incorporation was found, like the responses of cells activated by PHA and Con A, to markedly diminish with advancing age. The presence of indomethacin (1 μ/ml) or Ro 20-5720(10 μg/ml) in TPA activated cell cultures, unlike PHA stimulated cultures, did not result in augmentation of ³H-thymidine incorporation by cells from elderly individuals. These results demonstrate that prostaglandin synthesizing suppressor cells are not responsible for the age-related depression of cellular immune function observed in TPA activated cells and confirm the observation that decreased production and/or utilization of soluble mediators, such as IL-2, may account for the diminished mitogen responsiveness of lymphocytes from elderly individuals. [ABSTRACT FROM AUTHOR]
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KW  - LYMPHOCYTES
KW  - MITOGENS
KW  - THYMIDINE
KW  - CELL culture
KW  - DNA
KW  - LEUCOCYTES
N1  - Accession Number: 16062931; Nagel, J. E. 1 Chrest, F. J. 1 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA; Source Info: Oct1982, Vol. 50 Issue 1, p217; Subject Term: LYMPHOCYTES; Subject Term: MITOGENS; Subject Term: THYMIDINE; Subject Term: CELL culture; Subject Term: DNA; Subject Term: LEUCOCYTES; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - JORDAN, ELKE
AU  - CARRICO, CHRISTINE
AU  - BEYER, WILLIAM A.
T1  - DNA Database.
JO  - Science
JF  - Science
Y1  - 1982/10/08/
VL  - 218
IS  - 4568
M3  - Article
SP  - 108
EP  - 108
SN  - 00368075
N1  - Accession Number: 84705993; JORDAN, ELKE 1; CARRICO, CHRISTINE 1; BEYER, WILLIAM A. 2; Affiliations: 1: National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland 20205; 2: Theoretical Division, Group T-7, Los Alamos National Laboratory, Los Alamos, New Mexico 87545; Issue Info: 10/ 8/1982, Vol. 218 Issue 4568, p108; Number of Pages: 1/2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WARREN, DWIGHT W.
AU  - DUFAU, MARIA L.
AU  - CATT, KEVIN J.
T1  - Hormonal Regulation of Gonadotropin Receptors and Steroidogenesis in Cultured Fetal Rat Testes.
JO  - Science
JF  - Science
Y1  - 1982/10/22/
VL  - 218
IS  - 4570
M3  - Article
SP  - 375
EP  - 377
SN  - 00368075
AB  - Gonadotropic activation of the adult rat testis in vitro and in vivo is followed by down-regulation of luteinizing hormone receptors and decreased androgen responses to subsequent hormonal stimulation. In contrast, treatment of cultured fetal testes with gonadotropins and dibutyryl adenosine 3',5'-monophosphate enhanced steroidogenic responsiveness and did not cause the luteinizing hormone-receptor loss and desensitization that is characteristic of the adult gonad. The analysis of gonadotropin receptors and action in cultured fetal testis cells facilitates developmental studies of gonadal function, and has revealed significant differences in the responses of fetal and adult Leydig cells to gonadotropic regulation. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712145; WARREN, DWIGHT W. 1,2; DUFAU, MARIA L. 1; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Physiology, Biophysics, University of Southern California School of Medicine, Los Angeles 90033; Issue Info: 10/22/1982, Vol. 218 Issue 4570, p375; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WISE, STEVEN P.
AU  - HERKENHAM, MILES
T1  - Opiate Receptor Distribution in the Cerebral Cortex of the Rhesus Monkey.
JO  - Science
JF  - Science
Y1  - 1982/10/22/
VL  - 218
IS  - 4570
M3  - Article
SP  - 387
EP  - 389
SN  - 00368075
AB  - The distribution of opiate receptors in the cerebral cortex of the rhesus monkey (Macaca mulatta) was determined by autoradiographic visualization of [3H]naloxone binding to tissue sections. Naloxone was bound in relatively large amounts to the cortical laminae containing the cell bodies of output neurons, to a varying set of additional laminae in different cortical fields, to fields closer to more primitive types of cortex, and to polysensory corticalfields. From these laminar and areal variations in distribution, it appears that opiate receptors play a role in specific aspects of cortical function. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712150; WISE, STEVEN P. 1; HERKENHAM, MILES; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 10/22/1982, Vol. 218 Issue 4570, p387; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - MACKO, KATHLEEN A.
AU  - JARVIS, CHARLENE D.
AU  - KENNEDY, CHARLES
AU  - MIYAOKA, MIKOTO
AU  - SHINOHARA, MAMI
AU  - SOKOLOFF, Louis
AU  - MISHKIN, MORTIMER
T1  - Mapping the Primate Visual System with [2-14C]Deoxyglucose.
JO  - Science
JF  - Science
Y1  - 1982/10/22/
VL  - 218
IS  - 4570
M3  - Article
SP  - 394
EP  - 397
SN  - 00368075
AB  - The [2-14C]deoxyglucose method was used to identify the cerebral areas related to vision in the rhesus monkey (Macaca mulatta). This was achieved by comparing glucose utilization in a visually stimulated with that in a visually deafferented hemisphere. The cortical areas related to vision included the entire expanse of striate, prestriate, and inferior temporal cortex as far forward as the temporal pole, the posterior part of the inferior parietal lobule, and the prearcuate and inferior prefrontal cortex. Subcortically, in addition to the dorsal lateral geniculate nucleus and superficial layers of the superior colliculus, the structures related to vision included large parts of the pulvinar, caudate, putamen, claustrum, and amygdala. These results, which are consonant with a model of visual function that postulates an occipito-temporo-prefrontal pathway for object vision and an occipito-parieto-prefrontal pathway for spatial vision, reveal the full extent of those pathways and identify their points of contact with limbic, striatal, and diencephalic structures. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712153; MACKO, KATHLEEN A. 1; JARVIS, CHARLENE D. 1; KENNEDY, CHARLES 2; MIYAOKA, MIKOTO 2; SHINOHARA, MAMI 2; SOKOLOFF, Louis 2; MISHKIN, MORTIMER 3; Affiliations: 1: Laboratory of Neuropsychology, National Institute of Menial Health, Bethesda, Maryland 20205; 2: Laboratory of Cerebral Metabolism, National Institute of Mental Health; 3: Laboratory of Neuropsychology, National Institute of Mental Health; Issue Info: 10/22/1982, Vol. 218 Issue 4570, p394; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - PAUL, STEVEN M.
AU  - HULIHAN-GIBLIN, BRIDGET
AU  - SKOLNICK, PHIL
T1  - (+)-Amphetamine Binding to Rat Hypothalamus: Relation to Anorexic Potency of Phenylethylamines.
JO  - Science
JF  - Science
Y1  - 1982/10/29/
VL  - 218
IS  - 4571
M3  - Article
SP  - 487
EP  - 490
SN  - 00368075
AB  - Saturable and stereospecific binding sites for (+)-[HJamphetamine were demonstrated in membrane preparations from rat brain. The density of these binding sites varies among brain regions and is highest in the hypothalamus and brainstem. Specific (+)-[3H]amphetamine binding in hypothalamus is largely confined to synaptosomal membranes, rapidly reversible, and sensitive to both heat and proteolytic enzymes. Scatchard analysis of the equilibrium binding data revealed two distinct sites with apparent affinity constants of 93 and 300 nanomoles per liter, respectively. The effects of various psychotropic drugs as well as a number of putative neurotransmitters and related agonists and antagonists in displacing specific (+)-pHJamphetamine binding demonstrate that these binding sites are not associated with any previously described neurotransmitter or drug receptors, but are specific for amphetamine and related phenylethylamine derivatives. Furthermore, the relative affinities of a series of phenylethylamine derivates for (+)-[HJamphetamine binding sites in hypothalamic membranes is highly correlated to their potencies as anorexic agents. These results suggest the presence of specific receptor sites in hypothalamus that mediate the anorexic activity of amphetamine and related drugs. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712190; PAUL, STEVEN M. 1; HULIHAN-GIBLIN, BRIDGET 1; SKOLNICK, PHIL 2; Affiliations: 1: Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 10/29/1982, Vol. 218 Issue 4571, p487; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Kumar, Nirbhay
AU  - Flavin, Martin
T1  - Modulation of Some Parameters of Assembly of Microtubules in vitro by Tyrosinolation of Tubulin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1982/11//11/1/82
VL  - 128
IS  - 1
M3  - Article
SP  - 215
EP  - 222
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Using tyrosinolated and detyrosinolaled tubulins, we have compared several parameters of microtubule assembly in vitro. Rates and extents of polymerization were the same under all conditions, but microtubules assembled from detyrosinolated tubulin in the presence of crude microtubule-associated proteins (MAPs) or subsaturating MAP-2 contained a smaller proportion of the MAPs. Preliminary results indicate that this may be a function of the phosphorylation state of MAP-2. Tyrosinolated tubulin assembled into relatively shorter microtubules in the presence of saturating MAP-2. When assembly was induced with substoichiometric concentrations of taxol, in place of MAPs, the rate and extent of assembly were about twice as great with tyrosinolated tubulin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MICROTUBULES
KW  - TUBULINS
KW  - CELL organelles
KW  - CHEMICAL reactions
KW  - POLYMERS
KW  - PHOSPHORYLATION
KW  - BIOMOLECULES
N1  - Accession Number: 15808936; Kumar, Nirbhay 1 Flavin, Martin 1; Affiliation:  1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 11/1/82, Vol. 128 Issue 1, p215; Subject Term: MICROTUBULES; Subject Term: TUBULINS; Subject Term: CELL organelles; Subject Term: CHEMICAL reactions; Subject Term: POLYMERS; Subject Term: PHOSPHORYLATION; Subject Term: BIOMOLECULES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Engel, Bernard T.
AU  - Joseph, James A.
T1  - Attenuation of Baroreflexes During Operant Cardiac Conditioning.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1982/11//
VL  - 19
IS  - 6
M3  - Article
SP  - 609
EP  - 614
SN  - 00485772
AB  - Three monkeys were trained to slow and to speed heart rate on an operant schedule. After the animals were performing highly reliably they received injections of nitroglycerin or phenylephrine to elicit baro reflexes during control periods and during slowing or speeding sessions. The finding were that each animal reliably attenuated its baroreflex sensitivity and thereby avoided shock. Thus, the data showed that under appropriate behavioral conditions homeostatic adjustments of the cardiovascular system are reduced. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONKEYS
KW  - HEART beat
KW  - OPERANT conditioning
KW  - NITROGLYCERIN
KW  - BAROREFLEXES
KW  - REFLEXES
KW  - Baroreceptors
KW  - Baroreflex sensitivity
KW  - Biofeedback
KW  - Blood pressure
KW  - Cardiovascular
KW  - Heart rate
KW  - Nitroglycerin.
KW  - Operant conditioning
KW  - Phenylephrine
N1  - Accession Number: 14201467; Engel, Bernard T. 1,2 Joseph, James A. 1; Affiliation:  1: Gerontology Research Center (Baltimore). National Institute on Aging, National Institutes of Health, PHS, U.S. Department of Health and Human Services, Bethesda.  2: Baltimore City Hospital, Baltimore.; Source Info: Nov1982, Vol. 19 Issue 6, p609; Subject Term: MONKEYS; Subject Term: HEART beat; Subject Term: OPERANT conditioning; Subject Term: NITROGLYCERIN; Subject Term: BAROREFLEXES; Subject Term: REFLEXES; Author-Supplied Keyword: Baroreceptors; Author-Supplied Keyword: Baroreflex sensitivity; Author-Supplied Keyword: Biofeedback; Author-Supplied Keyword: Blood pressure; Author-Supplied Keyword: Cardiovascular; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Nitroglycerin.; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Phenylephrine; NAICS/Industry Codes: 325920 Explosives Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1469-8986.ep14201467
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06544-028
AN  - 2006-06544-028
AU  - Joseph, J. A.
T1  - Morpho-Physiological and Behavioral Relationships in Senescence.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1982/11//
VL  - 27
IS  - 11
SP  - 885
EP  - 885
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06544-028. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Joseph, J. A.; Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Aging; Central Nervous System; Geriatrics; Neural Receptors; Neurotransmitters. Minor Descriptor: Brain; Physiology. Classification: Neuropsychology & Neurology (2520); Gerontology (2860). Population: Human (10). Reviewed Item: Enna, S. J. (Ed); Samorajski, T. (Ed); Beer, Bernard (Ed). Aging, Vol. 17: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders=New York: Raven Press, 1981. 290 pp. $32.00; 1981. Page Count: 1. Issue Publication Date: Nov, 1982. 
AB  - Reviews the book, Aging, Vol. 17: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders by S. J. Enna, T. Samorajski, and Bernard Beer (Eds.) (1981). This volume describes in a fairly balanced fashion several aspects of changes occurring in the central nervous system (CNS) during aging. The book can serve as a good source of information to scientists in several disciplines. Several important topics are covered interspecies and methodological correlations in aging, CNS alterations and motor behavior, plasticity, and memory. Unfortunately, no attempt is made to speculate on the consequences of this decline in neuronal population for the aged human. Pertinent topics are well represented in this volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - central nervous system
KW  - aging
KW  - age related disorders
KW  - brain neurotransmitters
KW  - neural receptors
KW  - 1982
KW  - Aging
KW  - Central Nervous System
KW  - Geriatrics
KW  - Neural Receptors
KW  - Neurotransmitters
KW  - Brain
KW  - Physiology
KW  - 1982
U2  - Enna, S. J. (Ed); Samorajski, T. (Ed); Beer, Bernard (Ed). (1981); Aging, Vol. 17: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders; New York: Raven Press, 1981. 290 pp. $32.00
DO  - 10.1037/020772
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - KALYANARAMAN, V. S.
AU  - SARNGADHARAN, M. G.
AU  - ROBERT-GUROFF, MARJORIE
AU  - MIYOSHI, ISAO
AU  - BLAYNEY, DOUGLAS
AU  - GoLDE, DAVID
AU  - GALLO, ROBERT C.
T1  - A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia.
JO  - Science
JF  - Science
Y1  - 1982/11/05/
VL  - 218
IS  - 4572
M3  - Article
SP  - 571
EP  - 573
SN  - 00368075
AB  - Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with Tcell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and arefound in adults with an acute malignancy ofmature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A Tcell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I(cR), HTLV-I(MB), and HTLV-II(MO)1. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84706118; KALYANARAMAN, V. S. 1; SARNGADHARAN, M. G. 2; ROBERT-GUROFF, MARJORIE 2; MIYOSHI, ISAO 3; BLAYNEY, DOUGLAS 4; GoLDE, DAVID 5; GALLO, ROBERT C. 6; Affiliations: 1: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland 20895; 2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 3: Department of Internal Medicine, Kochi Medical School, Nankoku Kochi 781-SI, Japan; 4: Environmental Epidemiology Branch, National Cancer Institute; 5: Department of Medicine, University of California, Los Angeles 90024; 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 11/ 5/1982, Vol. 218 Issue 4572, p571; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FAVERA, RICCARDO DALLA
AU  - GALLO, ROBERT C.
AU  - GIALLONGO, AGATA
AU  - CROCE, CARLO M.
T1  - Chromosomal Localization of the Human Homolog (c-sis) of the Simian Sarcoma Virus onc Gene.
JO  - Science
JF  - Science
Y1  - 1982/11/12/
VL  - 218
IS  - 4573
M3  - Article
SP  - 686
EP  - 688
SN  - 00368075
AB  - Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region qll-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22qll>qter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712227; FAVERA, RICCARDO DALLA 1; GALLO, ROBERT C. 1; GIALLONGO, AGATA 2; CROCE, CARLO M. 2; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, 36th Street, Spruce, Philadelphia, Pennsylvania 19104; Issue Info: 11/12/1982, Vol. 218 Issue 4573, p686; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MUKHERJEE, ANIL B.
AU  - HODGEN, GARY D.
T1  - Maternal Ethanol Exposure Induces Transient Impairment of Umbilical Circulation and Fetal Hypoxia in Monkeys.
JO  - Science
JF  - Science
Y1  - 1982/11/12/
VL  - 218
IS  - 4573
M3  - Article
SP  - 700
EP  - 702
SN  - 00368075
AB  - When ethanol was administered intravenously to pregnant monkeys, a transient but marked collapse of umbilical vasculature was observed uniformly within about 15 minutes. The ethanol-induced impairment of umbilical circulation produced severe hypoxia and acidosis in the fetus; recovery occurred during the succeeding hour. This striking interruption offeto-placental circulation may explain one of the mechanisms of mental retardation, a frequent manifestation in children afflicted with fetal alcohol syndrome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712235; MUKHERJEE, ANIL B. 1; HODGEN, GARY D. 1; Affiliations: 1: Pregnancy Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/12/1982, Vol. 218 Issue 4573, p700; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEST, JAMES R.
AU  - LIND, MARCIA D.
AU  - DEMUTH, RONALD M.
AU  - PARKER, ELIZABETH S.
AU  - ALKANA, RONALD L.
AU  - CASSELL, MARTIN
AU  - BLACK JR., ASA C.
T1  - Lesion-Induced Sprouting in the Rat Dentate Gyrus Is Inhibited by Repeated Ethanol Administration.
JO  - Science
JF  - Science
Y1  - 1982/11/19/
VL  - 218
IS  - 4574
M3  - Article
SP  - 808
EP  - 810
SN  - 00368075
AB  - The effect of ethanol on hippocampal axonal sprouiting was studied with a histochemical technique for identifying acetylcholinesterase. Unilateral lesion of the entorhinal cortex in adult rats produced an increase in the density of acetylcholinesterase staining in the outer molecular layer and a concomitant increase in the width of the pale-staining commissural-associational zone of the dentate gyrus. Other rats were given ethanol (11.3 ± 0.45 grams per kilogram) for 2 weeks before and 9 days after receiving the lesion. Ethanol abolished the expansion of the commissural-associational zone. The effect of ethanol on sprouting axons suggests that it may inhibit recovery of function after brain injury. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712271; WEST, JAMES R. 1; LIND, MARCIA D. 1; DEMUTH, RONALD M. 2; PARKER, ELIZABETH S. 3; ALKANA, RONALD L. 4; CASSELL, MARTIN 5; BLACK JR., ASA C. 5; Affiliations: 1: Department of Anatomy, University of Iowa College of Medicine, Iowa City 52242; 2: Department of Psychology, University of Northern Illinois, De Kalb 60115; 3: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20205; 4: Institute of Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033; 5: Department of Anatomy, University of Iowa College of Medicine; Issue Info: 11/19/1982, Vol. 218 Issue 4574, p808; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - AASLESTAD, HALVOR G.
T1  - Peer Review at NIH.
JO  - Science
JF  - Science
Y1  - 1982/11/26/
VL  - 218
IS  - 4575
M3  - Article
SP  - 840
EP  - 840
SN  - 00368075
N1  - Accession Number: 84712275; AASLESTAD, HALVOR G. 1; Affiliations: 1: Biological Sciences Review Section, Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/26/1982, Vol. 218 Issue 4575, p840; Number of Pages: 5/6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Bailey, Kent
T1  - Biometry (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1982/12//
VL  - 77
IS  - 380
M3  - Book Review
SP  - 946
SN  - 01621459
AB  - Reviews the book "Biometry: The Principles and Practice of Statistics in Biological Research," by Robert R. Sokal and F. James Rohlf.
KW  - BIOMETRY
KW  - NONFICTION
KW  - SOKAL, Robert
KW  - SOKAL, Robert R.
KW  - ROHLF, F. James
KW  - BIOMETRY (Book)
N1  - Accession Number: 4606385; Bailey, Kent 1; Affiliations: 1: National Heart, Lung and Blood Institute.; Issue Info: Dec82, Vol. 77 Issue 380, p946; Subject Term: BIOMETRY; Subject Term: NONFICTION; Reviews & Products: BIOMETRY (Book); People: SOKAL, Robert; People: SOKAL, Robert R.; People: ROHLF, F. James; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - BLAIR, D. G.
AU  - COOPER, C. S.
AU  - OSKARSSON, M. K.
AU  - EADER, L. A.
AU  - WOUDE, G. F. VANDE
T1  - New Method for Detecting Cellular Transforming Genes.
JO  - Science
JF  - Science
Y1  - 1982/12/10/
VL  - 218
IS  - 4577
M3  - Article
SP  - 1122
EP  - 1125
SN  - 00368075
AB  - Tumor induction in athymic nude mice can be used to detect dominant transforming genes in cellular DNA. Mouse NIH 3T3 cells freshly transfected with either cloned Moloney sarcoma proviral DNA or cellular DNA's derivedfrom virally transformed cells induced tumors when injected into athymic nulnu mice. Tumors were also induced by cells transfected with DNA from two tumor-derived and one chemically transformed human cell lines. The mouse tumors induced by human cell line DNA's contained human DNA sequences, and DNA derivedfrom these tumors was capable of inducing both tumors and foci on subsequent transfection. Tumor induction in nude mice represents a useful new method for the detection and selection of cells transformed by cellular oncogenes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712387; BLAIR, D. G. 1; COOPER, C. S. 2; OSKARSSON, M. K. 2; EADER, L. A. 3,4; WOUDE, G. F. VANDE 2; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Molecular Oncology, National Cancer Institute, Bethesda, Maryland 20205; 3: National Institutes Health, Intramural Research Support Program; 4: National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 12/10/1982, Vol. 218 Issue 4577, p1122; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ALLEN, ROBERT DAY
AU  - METUZALS, JANIS
AU  - TASAKI, ICHUI
AU  - BRADY, SCOOT T.
AU  - GILBERT, SUSAN P.
T1  - Fast Axonal Transport in Squid Giant Axon.
JO  - Science
JF  - Science
Y1  - 1982/12/10/
VL  - 218
IS  - 4577
M3  - Article
SP  - 1127
EP  - 1129
SN  - 00368075
AB  - Video-enhanced contrast-differential interference contrast microscopy has revealed new features of axonal transport in the giant axon of the squid, where no movement had been detected previously by conventional microscopy. The newly discovered dominant feature is vast numbers of "submicroscopic" particles, probably 30- to 50-nanometer vesicles and other tubulovesicular elements, moving parallel to linear elements, primarily in the orthograde direction but also in a retrograde direction, at a range of steady velocities up to ±5 micrometers per second. Medium (0.2 to 0.6 micrometer) and large (0.8 micrometer) particles move more slowly and more intermittently with a tendency at times to exhibit elastic recoil. The behavior of the smallest particles and the larger particles during actual translocation suggests that the fundamental processes in the mechanisms of organelle movement in axonal transport are not saltatory but continuous. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712389; ALLEN, ROBERT DAY 1; METUZALS, JANIS 2; TASAKI, ICHUI 3; BRADY, SCOOT T. 4; GILBERT, SUSAN P. 5; Affiliations: 1: Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755; 2: Department of Anatomy, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada KIN 9A9; 3: Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20014; 4: Department of Anatomy, Case Western Reserve Medical School, Cleveland, Ohio 44106; 5: Department of Biological Sciences, Dartmouth College; Issue Info: 12/10/1982, Vol. 218 Issue 4577, p1127; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ROBBINS, KEITH C.
AU  - DEVARE, SUSHILKUMAR G.
AU  - REDDY, E. PREMKUMAR
AU  - AARONSON, STUART A.
T1  - In vivo Identification of the Transforming Gene Product of Simian Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1982/12/10/
VL  - 218
IS  - 4577
M3  - Article
SP  - 1131
EP  - 1133
SN  - 00368075
AB  - Simian sarcoma virus (SSV) deletion mutants were constructed from a molecular clone containing the entire infectious provirus. Transfection analysis of these mutants localized the SSV transforming gene to a small region of the viral genome encompassing its cell-derived sequence (v-sis). Antiserum to a peptide synthesized on the basis of the predicted amino acid sequence of the SSV transforming gene detected a 28,000-dalton protein that was specifically expressed in SSV transformed cells and that corresponded in size to that predicted from the v-sis coding sequence. The v-sis gene product designated p28sis was not a phosphoprotein, nor did it possess detectable protein kinase activity. These findings distinguish p28sis from a number of other retroviral onc proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712391; ROBBINS, KEITH C. 1; DEVARE, SUSHILKUMAR G. 1; REDDY, E. PREMKUMAR 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 12/10/1982, Vol. 218 Issue 4577, p1131; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LOUMAYE, ERNEST
AU  - THORNER, JEREMY
AU  - CATT, KEVIN J.
T1  - Yeast Mating Pheromone Activates Mammalian Gonadotrophs: Evolutionary Conservation of a Reproductive Hormone?
JO  - Science
JF  - Science
Y1  - 1982/12/24/
VL  - 218
IS  - 4579
M3  - Article
SP  - 1323
EP  - 1325
SN  - 00368075
AB  - α-Factor, a tridecapeptide mating pheromone of yeast (Saccharomyces cerevisiae), has extensive sequence homology with the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH). Both synthetic and natural preparations of α-mating factor were found to bind specifically to rat pituitary GnRH receptors and to stimulate the release of luteinizing hormonefrom cultured gonadotrophs. The ability of the yeast pheromone to reproduce the biological actions of GnRH in the mammalian pituitary gland indicates that the structural andfunctional properties of GnRH-related peptides may have been highly conserved during evolution. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712468; LOUMAYE, ERNEST 1,2; THORNER, JEREMY 3; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20816; 2: Department of Obstetrics and Gynecology, University of Louvain, 5330. 53 av. Em. Mounier, B-1200, Brussels, Belgium; 3: Departtnent of Microbiology and Immunology, University of California, Berkeley 94720; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1323; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MURPHY, BRIAN R.
AU  - SLY, D. LEWIS
AU  - TIERNEY, EVELINE L.
AU  - HOSIER, NANETTE T.
AU  - MASSICOT, JUDITH G.
AU  - LONDON, WILLIAM T.
AU  - CHANOCK, ROBERT M.
AU  - WEBSTER, ROBERT G.
AU  - HINSHAW, VIRGINIA S.
T1  - Reassortant Virus Derived from Avian and Human Influenza A Viruses Is Attenuated and Immunogenic in Monkeys.
JO  - Science
JF  - Science
Y1  - 1982/12/24/
VL  - 218
IS  - 4579
M3  - Article
SP  - 1330
EP  - 1332
SN  - 00368075
AB  - An influenza A reassortant virus that contained the hemagglutinin and neuraminidase genes of a virulent human virus, A/Udorn/72 (H3N2), and the six other influenza A virus genome segments from an avirulent avian virus, AlMallardl New York/6750/78 (H2N2), was evaluated for its level of replication in squirrel monkeys and hamsters. In monkeys, the reassortant virus was as attenuated and as restricted in its level of replication in the upper and lower respiratory tract as its avian influenza virus parent. Nonetheless, infection with the reassortant induced significant resistance to challenge with virulent human influenza virus. In hamsters, the reassortant virus replicated to a level intermediate between that of its parents. These findings suggest that the nonsurface antigen genes of the avian parental virus are the primary determinants of restriction of replication of the reassortant virus in monkeys. Attenuation of the reassortant virus for primates is achieved by the inefficient functioning of the avian influenza genes in primate cells, while antigenic specificity of the human influenza virus is provided by the neuraminidase and hemagglutinin genes derivedfrom the human virus. This approach could lead to the development of a live influenza A virus vaccine that is attenuatedfor man if the avian influenza genes are similarly restricted in human cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712471; MURPHY, BRIAN R. 1,2; SLY, D. LEWIS 3; TIERNEY, EVELINE L. 4; HOSIER, NANETTE T. 4; MASSICOT, JUDITH G. 4; LONDON, WILLIAM T. 5,6; CHANOCK, ROBERT M. 4; WEBSTER, ROBERT G. 7; HINSHAW, VIRGINIA S. 7; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy, Bethesda, Maryland 20205; 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Meloy Laboratories, Rockville, Maryland 20851; 4: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; 5: National Institute of Neurological and Communicative Disorders and Stroke; 6: National Institutes of Health; 7: Division of Virology, St. Jude Children's Hospital, Memphis, Tennessee 28101; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1330; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - NINAN, PHILIP T.
AU  - INSEL, THOMAS M.
AU  - COHEN, ROBERT M.
AU  - COOK, JAMES M.
AU  - SKOLNICK, PHIL
AU  - PAUL, STEVEN M.
T1  - Benzodiazepine Receptor-Mediated Experimental "Anxiety" in Primates.
JO  - Science
JF  - Science
Y1  - 1982/12/24/
VL  - 218
IS  - 4579
M3  - Article
SP  - 1332
EP  - 1334
SN  - 00368075
AB  - The ethyl ester of β-carboline-3-carboxylic acid has a high affinity for benzodiazepine receptors in the brain. In the rhesus monkey this substance produces an acute behavioral syndrome characterized by dramatic elevations in heart rate, blood pressure, plasma cortisol, and catecholamines. The effects are blocked by benzodiazepines and the specific benzodiazepine receptor antagonist Ro 15-1788. The benzodiazepine receptor may consist of several subsites or functional domains that independently recognize agonists, antagonists, or "active" antagonists such as β-carboline-3-carboxylic acid ethyl ester. These results suggest that the benzodiazepine receptor is involved in both the affective and physiological manifestations of anxiety, and that the administration of β-carboline-3-carboxylic acid ethyl ester to monkeys may provide a reliable and reproducible animal model of human anxiety. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712472; NINAN, PHILIP T. 1; INSEL, THOMAS M. 2; COHEN, ROBERT M. 2; COOK, JAMES M. 3; SKOLNICK, PHIL 4; PAUL, STEVEN M. 5; Affiliations: 1: Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Clinical Neuropharmacology Branch, National Institute of Mental Health; 3: Department of Chemistry, University of Wisconsin, Milwaukee 53201; 4: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; 5: Clinical Neuroscience Branch, National Institute of Mental Health; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1332; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSTEIN, JOHN N.
AU  - PARKER, ROBERT J.
AU  - KEENAN, ANDREW M.
AU  - DOWER, STEVEN K.
AU  - MORSE III, HERBERT C.
AU  - SIEBER, SUSAN M.
T1  - Monoclonal Antibodies in the Lymphatics: Toward the Diagnosis and Therapy of Tumor Metastases.
JO  - Science
JF  - Science
Y1  - 1982/12/24/
VL  - 218
IS  - 4579
M3  - Article
SP  - 1334
EP  - 1337
SN  - 00368075
AB  - Monoclonal antibodies subcutaneously injected into mice track to regional lymph nodes and specifically label target cells there. The lymphatic route of administration can be expected to provide much higher sensitivity, higher target-tobackground ratio, faster localization, and lower toxicity than the intravenous route when the aim is to diagnose or treat tumor metastases or lymphoma in the lymph nodes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712473; WEINSTEIN, JOHN N. 1; PARKER, ROBERT J. 2; KEENAN, ANDREW M. 3; DOWER, STEVEN K. 4; MORSE III, HERBERT C. 5; SIEBER, SUSAN M. 2; Affiliations: 1: Laboratory of Mathematical Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Laboratory of Chemical Pharmacology, National Cancer Institute; 3: Department of Nuclear Medicine, National Institutes of Health, Bethesda, Maryland 20205; 4: Immunology Branch, National Cancer Institute; 5: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1334; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ZOLA-MORGAN, STUART
AU  - SQUIRE, LARRY R.
AU  - MISHKIN, MORTIMER
T1  - The Neuroanatomy of Amnesia: Amygdala-Hippocampus versus Temporal Stem.
JO  - Science
JF  - Science
Y1  - 1982/12/24/
VL  - 218
IS  - 4579
M3  - Article
SP  - 1337
EP  - 1339
SN  - 00368075
AB  - Using a task known to be sensitive to human amnesia, we have evaluated two current hypotheses about which brain regions must be damaged to produce the disorder. Monkeys with bilateral transections of the white matter of the temporal stem were unimpaired, but monkeys with conjoint amygdala-hippocampal lesions exhibited a severe memory deficit. The results indicate that the hippocampus, amygdala, or both, but not the temporal stem, are involved in memory in the monkey and suggest that a rapprochement between the findings for the human and the nonhuman primate may be close at hand. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712474; ZOLA-MORGAN, STUART 1,2; SQUIRE, LARRY R. 1,2; MISHKIN, MORTIMER 3; Affiliations: 1: Veterans Administration Medical Center, San Diego, California 92161; 2: Department of Psychiatry, University of California, San Diego; 3: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1337; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hiller, Rita
AU  - Krueger, Dean E.
T1  - Validity of a Survey Question as a Measure of Visual Acuity Impairment.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1983/01//
VL  - 73
IS  - 1
M3  - Article
SP  - 93
EP  - 96
PB  - American Public Health Association
SN  - 00900036
AB  - Survey questions are frequently used to collect data on the prevalence of vision difficulties. The 1971-1972 Health and Nutrition Examination Survey included both a question about ‘trouble with your vision even when wearing glasses or contact lenses,’ and clinical measurement of central distance visual acuity with usual corrective lenses. The question had low sensitivity for impairment of visual acuity, with variation by age and severity of impairment. Sensitivity analyses from other studies are reviewed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH surveys
KW  - VISUAL acuity
KW  - VISION disorders
KW  - HEALTH & Nutrition Examination Survey
KW  - OPHTHALMIC lenses
KW  - CONTACT lenses
KW  - EYE -- Examination
KW  - EYE -- Care & hygiene
KW  - EYE -- Diseases
N1  - Accession Number: 4949175; Hiller, Rita 1 Krueger, Dean E. 2; Affiliation:  1: MS, Office of Biometry and Epidemiology, National Eye Institute, Bldg. 31, Rm. 6A24, Bethesda, MD 20205  2: Biostatistics Center, George Washington University; Source Info: Jan1983, Vol. 73 Issue 1, p93; Subject Term: HEALTH surveys; Subject Term: VISUAL acuity; Subject Term: VISION disorders; Subject Term: HEALTH & Nutrition Examination Survey; Subject Term: OPHTHALMIC lenses; Subject Term: CONTACT lenses; Subject Term: EYE -- Examination; Subject Term: EYE -- Care & hygiene; Subject Term: EYE -- Diseases; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423460 Ophthalmic Goods Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jacobs, Barry E.
AU  - Walczak, Cynthia A.
T1  - A Generalized Query-by-Example Data Manipulation Language Based on Database Logic.
JO  - IEEE Transactions on Software Engineering
JF  - IEEE Transactions on Software Engineering
Y1  - 1983/01//
VL  - 9
IS  - 1
M3  - Article
SP  - 40
EP  - 57
SN  - 00985589
AB  - The purpose of this paper is to introduce a Generalized-Query-By-Example (GQBE) data manipulation language (DML) that can be built on top of most existing databases (i.e., relational, hierarchical, and network). The data manipulation language supports retrieval, insertion, deletion, and update operations and has a formal semantics based on database logic. It is also seen that GQBE can by used as a DML on external views of an integrated database. We also show the advantages of GQBE on heterogeneous databases over Zloof's QBE on relational external views. [ABSTRACT FROM AUTHOR]
AB  - Copyright of IEEE Transactions on Software Engineering is the property of IEEE Computer Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DATABASES
KW  - COMPUTER logic
KW  - INFORMATION storage & retrieval systems
KW  - SOFTWARE engineering
KW  - COMPUTER software
KW  - COMPUTER systems
KW  - Database
KW  - database logic
KW  - generalized Query-By- Example.
N1  - Accession Number: 14403920; Jacobs, Barry E. 1 Walczak, Cynthia A. 2; Affiliation:  1: Department of Computer Science, University of Maryland, College Park, MD 20742  2: Microbial Systematics Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20205; Source Info: Jan83, Vol. 9 Issue 1, p40; Subject Term: DATABASES; Subject Term: COMPUTER logic; Subject Term: INFORMATION storage & retrieval systems; Subject Term: SOFTWARE engineering; Subject Term: COMPUTER software; Subject Term: COMPUTER systems; Author-Supplied Keyword: Database; Author-Supplied Keyword: database logic; Author-Supplied Keyword: generalized Query-By- Example.; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 18p; Illustrations: 8 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Giambra, Leonard M.
T1  - DAYDREAMING IN 40- TO 60-YEAR-OLD WOMEN: MENOPAUSE, HEALTH, VALUES, AND SEXUALITY.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1983/01//
VL  - 39
IS  - 1
M3  - Article
SP  - 11
EP  - 21
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article focuses on a study related to daydreaming in 40 to 60 year old women. Two midlife influences are found to have its impact in daydreaming. This study reveals that daydreaming tend to be more prevalent among women who exhibit various psychological symptoms. These symptoms include poor physical health and abnormal variability of menopause. The period from 40 to 60 years of age, in women, bears a most important biological event, which is the period of transition to menopause. A clear change in hormonal balance is accompanied during this transition phase as well as the cessation of menses. Often the transition period is accompanied by psychological, sociological, social, familial, and economic changes that may be causally unrelated to the menopause itself. According to the study, menopause occurs with the cessation of menses. The main impact of menopause on Fear of Failure Daydreams reveals that the means increase as groups shift from pre-menopausal to menopausal to post-menopausal.
KW  - DREAMS
KW  - SLEEP disorders
KW  - MENOPAUSE
KW  - MENSTRUATION
KW  - CLINICAL psychology
KW  - CLIMACTERIC
N1  - Accession Number: 19103203; Giambra, Leonard M. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals.; Source Info: Jan1983, Vol. 39 Issue 1, p11; Subject Term: DREAMS; Subject Term: SLEEP disorders; Subject Term: MENOPAUSE; Subject Term: MENSTRUATION; Subject Term: CLINICAL psychology; Subject Term: CLIMACTERIC; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hardy, Margaret H.
AU  - van Exan, R. J.
AU  - Sonstegard, Karen S.
AU  - Sweeny, P. R.
T1  - Basal Lamina Changes During Tissue Interactions in Hair Follicles--An In Vitro Study of Normal Dermal Papillae and Vitamin A-Induced Glandular Morphogenesis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/01//
VL  - 80
IS  - 1
M3  - Article
SP  - 27
EP  - 34
SN  - 0022202X
AB  - Skin pieces from 14-day fetal mice were cultivated for 1-10 days prior to fixation and sectioning. Subsequently, sections were studied by light and transmission electron microscopy. In a standard medium the lateral hair follicle walls showed progressive maturation of the basal lamina, while the hair matrix, at the time of a known tissue interaction, showed the formation of gaps in the basal lamina, With heterotypic cell contacts through the gaps. In a vitamin-A enriched medium similar changes occurred, not only at the hair matrix, but also at lateral follicle walls, at the sites of, and prior to, budding and glandular morphogenesis. This study shows that the induction of hair matrix by dermal papilla may perhaps be added to the list of normal tissue interactions in which heterotypic cell contacts occur. It also suggests that vitamin-A induced glandular morphogenesis might come about through a mechanism resembling a normal tissue interaction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ELECTRON microscopy
KW  - MASONRY
KW  - MORPHOLOGY
KW  - TRANSMISSION electron microscopy
KW  - MORPHOGENESIS
KW  - MATRICES
N1  - Accession Number: 12530968; Hardy, Margaret H. 1,2 van Exan, R. J. 1,3 Sonstegard, Karen S. 1,4 Sweeny, P. R. 2; Affiliation:  1: Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.  2: Department of Microbiology, University of Guelph, Guelph, Ontario, Canada.  3: Connaught Medical Research Laboartories, 1755 Steele Avenue West, Willowdale, Ontario.  4: National Institute of Environmental Health Sciences, Triangle Park, North Carolina.; Source Info: Jan1983, Vol. 80 Issue 1, p27; Subject Term: ELECTRON microscopy; Subject Term: MASONRY; Subject Term: MORPHOLOGY; Subject Term: TRANSMISSION electron microscopy; Subject Term: MORPHOGENESIS; Subject Term: MATRICES; NAICS/Industry Codes: 238140 Masonry Contractors; NAICS/Industry Codes: 327310 Cement Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12530968
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2008-09089-005
AN  - 2008-09089-005
AU  - Weiss, Stephen M.
T1  - Planning the conference.
T3  - Proceedings of the National Working Conference on Education and Training in Health Psychology
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1983///
VL  - 2
IS  - 5, Suppl
SP  - 19
EP  - 25
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-09089-005. Partial author list: First Author & Affiliation: Weiss, Stephen M.; National Heart, Lung, and Blood Institute, US. Other Publishers: American Psychological Association. Release Date: 20080714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Psychology; Psychologists; Scientific Communication. Minor Descriptor: American Psychological Association Divisions. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 7. Issue Publication Date: 1983. 
AB  - Since the founding of Division 38 nearly 6 years ago, the sub-discipline of 'Health Psychology' has sustained dramatic growth. This has been due, in large measure, to the new opportunities in health settings that have become available through recognition of the role of behavioral and environmental factors in chronic disease prevention and control. Behavioral medicine, preventive medicine, behavioral health, and health promotion are all relatively new approaches to health and disease issues that require major input from appropriately trained behavioral scientists. These developments have stimulated a need for training resources at the graduate, postgraduate, and continuing education levels to adequately prepare psychologists to function in health settings related to basic and clinical research as well as applied care. Several academic programs have already been developed in health psychology in an effort to be responsive to this perceived need. Increasing numbers of academic institutions have expressed strong interest in developing such programs. It appeared timely for the Division of Health Psychology to review the accomplishments (and difficulties) experienced to date by the existing training programs, to assess requisite skills and knowledge required to function effectively in the various research, professional, and administrative health settings and to formulate guidelines and recommended standards for graduate, postgraduate, and continuing educational levels of training in health psychology. This article reviews the planning and implementation process that went in to developing the National Working Conference on Education and Training in Health Psychology, held in May, 1983. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - National Working Conference on Education and Training in Health Psychology
KW  - conference planning
KW  - APA Division of Health Psychology
KW  - 1983
KW  - Health Care Psychology
KW  - Psychologists
KW  - Scientific Communication
KW  - American Psychological Association Divisions
KW  - 1983
DO  - 10.1037/h0090287
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06531-022
AN  - 2006-06531-022
AU  - Coelho, George V.
T1  - Coping Behavior in Disasters.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1983/01//
VL  - 28
IS  - 1
SP  - 36
EP  - 37
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06531-022. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Coelho, George V.; Research Development Review Branch, Office of Extramural Project Review, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Coping Behavior; Disasters; Mental Health; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Cohen, Raquel E.; Ahearn, Frederick L. Jr. Handbook for Mental Health Care of Disaster Victims=Baltimore, Md.: Johns Hopkins University Press, 1980. 143 pp. $12.95 cloth; 1980. Page Count: 2. Issue Publication Date: Jan, 1983. 
AB  - Reviews the book, Handbook for Mental Health Care of Disaster Victims by Raquel E. Cohen and Frederick L. Ahearn, Jr. (1980). This slim handbook consists of nine chapters organized around two main foci: (a) mental health factors relevant to disaster events and (b) mental health practices applicable to victims of disaster. The volume's broad scope is impressive. Yet while espousing, implicitly, ethnographic methods, it seems to entertain monocultural assumptions. This handbook, unlike the typical handbook in psychology, is handy; primarily designed for the practitioner, it is portable and usable as a field operations manual. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health care
KW  - disaster victims
KW  - coping behavior
KW  - 1983
KW  - Coping Behavior
KW  - Disasters
KW  - Mental Health
KW  - Mental Health Services
KW  - 1983
U2  - Cohen, Raquel E.; Ahearn, Frederick L. Jr. (1980); Handbook for Mental Health Care of Disaster Victims; Baltimore, Md.: Johns Hopkins University Press, 1980. 143 pp. $12.95 cloth
DO  - 10.1037/021541
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09089-010
AN  - 2008-09089-010
AU  - MacCanon, Donald
T1  - Research training interests of the Division of Heart and Vascular Diseases of the National Heart, Lung, and Blood Institute.
T3  - Proceedings of the National Working Conference on Education and Training in Health Psychology
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1983///
VL  - 2
IS  - 5, Suppl
SP  - 63
EP  - 65
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-09089-010. Partial author list: First Author & Affiliation: MacCanon, Donald; National Heart, Lung, and Blood Institute, US. Other Publishers: American Psychological Association. Release Date: 20080714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Change; Cardiovascular Disorders; Health Education; Interdisciplinary Research; Prevention. Minor Descriptor: Government Agencies; Health Care Psychology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 3. Issue Publication Date: 1983. 
AB  - Discusses the importance of interdisciplinary collaboration and communication. Communication and understanding of cardiovascular problems by other disciplinary members is a huge challenge. During the last 20 years the mortality rate from coronary heart disease has decreased by 30%. Changes in human behavior such as cessation of smoking, improved dietary and exercise habits seem to account for a large portion of the improvement. Despite these advances, cardiovascular disease continues to be the number one cause of death in the United States. New fundamental and clinical discoveries in addition to behavioral changes may make it possible to prevent the development of cardiovascular disease. This belief is reflected in the Congressional Mandate of the National Heart, Lung, and Blood Institute to encourage programs to promote Prevention, Education, and Control of Diseases in these areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - interdisciplinary collaboration
KW  - cardiovascular disease
KW  - human behavior
KW  - behavioral changes
KW  - prevention
KW  - education
KW  - National Heart
KW  - Lung
KW  - and Blood Institute
KW  - congressional mandate
KW  - 1983
KW  - Behavior Change
KW  - Cardiovascular Disorders
KW  - Health Education
KW  - Interdisciplinary Research
KW  - Prevention
KW  - Government Agencies
KW  - Health Care Psychology
KW  - 1983
DO  - 10.1037/h0090292
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09727-002
AN  - 2005-09727-002
AU  - Schooler, Nina R.
AU  - Carpenter, William T. Jr.
T1  - New Drug Treatment Strategies in Schizophrenia: Editorial Introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1983///
VL  - 9
IS  - 4
SP  - 500
EP  - 503
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Schooler, Nina R., Pharmacologic and Somatic Treatments Branch, Division of Extramural Research Programs, NIMH, Parklawn Bldg., Room 10-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09727-002. PMID: 6140749 Partial author list: First Author & Affiliation: Schooler, Nina R.; Pharmacologic and Somatic Treatments Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dosages; Neuroleptic Drugs; Psychosocial Rehabilitation; Schizophrenia; Symptoms. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 4. Issue Publication Date: 1983. 
AB  - The recognition of both the value and limitations of antipsychotic drug treatment has led to research on effective alternative strategies for treatment. The authors review assumptions underlying such strategies and introduce five articles pertinent to the topic. These articles address: the use of drugs other than antipsychotic neuroleptics; the use of reduced dosages of antipsychotic drugs; the initiation of antipsychotic drugs early during periods of symptom exacerbation to prevent full relapse; the use of psychosocial treatment strategies in relation to drug treatment; and the development of antipsychotic drugs following models based on restitutive systems in the brain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - antipsychotic drugs
KW  - drug treatment strategies
KW  - reduced dosage strategy
KW  - psychosocial treatment strategies
KW  - antipsychotic neuroleptics
KW  - symptom exacerbation
KW  - schizophrenia
KW  - 1983
KW  - Drug Dosages
KW  - Neuroleptic Drugs
KW  - Psychosocial Rehabilitation
KW  - Schizophrenia
KW  - Symptoms
KW  - 1983
DO  - 10.1093/schbul/9.4.500
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Arnow, Kathryn Smul
T1  - The University's Entry Fee to Federal Research Programs.
JO  - Science
JF  - Science
Y1  - 1983/01/07/
VL  - 219
IS  - 4580
M3  - Article
SP  - 27
EP  - 32
SN  - 00368075
N1  - Accession Number: 84712484; Arnow, Kathryn Smul 1; Affiliations: 1: Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/ 7/1983, Vol. 219 Issue 4580, p27; Number of Pages: 6p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - KOPIN, IRWIN J.
AU  - GORDON, E. K.
AU  - JIMERSON, D. C.
AU  - POLINSKY, R. J.
T1  - Relation Between Plasma and Cerebrospinal Fluid Levels of 3-Methoxy-4-Hydroxyphenylglycol.
JO  - Science
JF  - Science
Y1  - 1983/01/07/
VL  - 219
IS  - 4580
M3  - Article
SP  - 73
EP  - 75
SN  - 00368075
AB  - Concentrations of free 3-methoxy4-hydroxyphenylglycol in the plasma and cerebrospinalfluid are highly correlated, but concentrations in the cerebrospinal fluid are always higher than those in plasma, even when large amounts of the catecholamine metabolite are derived from a tumor of the adrenal medulla. This is explained by considering the plasma and cerebrospinalfluid as a two-compartment system in which the rate constants for entry into and exitfrom the cerebrospinalfluid compartment are similar. 3-Methoxy4-hydroxyphenylglycol that is synthesized, but not catabolized, in the central nervous system maintains cerebrospinalfluid levels at an increment over those in plasma. This increment can be used to provide the best available index of formation of 3-methoxy4-hydroxyphenylglycol in the central nervous system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712512; KOPIN, IRWIN J. 1; GORDON, E. K. 1; JIMERSON, D. C. 1; POLINSKY, R. J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 1/ 7/1983, Vol. 219 Issue 4580, p73; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - LAZARUS, L. H.
AU  - DIAUGUSTINE, R. P.
AU  - JAHNKE, G. D.
AU  - HERNANDEZ, O.
T1  - Physalaemin: An Amphibian Tachykinin in Human Lung Small-Cell Carcinoma.
JO  - Science
JF  - Science
Y1  - 1983/01/07/
VL  - 219
IS  - 4580
M3  - Article
SP  - 79
EP  - 81
SN  - 00368075
AB  - Immunoreactivity to the amphibian peptide physalaemin was characterized from extracts of a human lung small-cell carcinoma by immunological, chemical, and pharmacological means. Tumor-related peptide cross-reacted with three antiserums to physalaemin to yield 1.1 to 1.6 nanomoles per gram of tissue. Physalaemin and tumor peptide had similar retention times on high-performance liquid chromatography after chemical and enzymic modifications that included pH changes, oxone oxidation, use of a hydrophilic ion-pairing reagent, and digestion with trypsin and pyroglutamate aminopeptidase. Both physalaemin and the tumor peptide produced a contractile response of isolated guinea pig ileum at threshold concentrations of approximately 100 to 150 picograms per milliliter. These data suggest that small-cell carcinoma of the lung contains a physalaemin-like peptide that has structural and biological homology to its amphibian counterpart. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712515; LAZARUS, L. H. 1; DIAUGUSTINE, R. P. 2; JAHNKE, G. D. 3; HERNANDEZ, O. 4; Affiliations: 1: Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2770; 2: Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences; 3: School of Veterinary Medicine, North Carolina State University, Raleigh 27650; 4: Laboratory of Environmental Chemistry, National Institute of Environmental Health Sciences; Issue Info: 1/ 7/1983, Vol. 219 Issue 4580, p79; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - ALKON, DANIEL L.
AU  - ACOSTA-URQUIDI, JUAN
AU  - OLDS, JAMES
AU  - KUZMA, GREGORY
AU  - NEARY, JOSEPH T.
T1  - Protein Kinase Injection Reduces Voltage-Dependent Potassium Currents.
JO  - Science
JF  - Science
Y1  - 1983/01/21/
VL  - 219
IS  - 4582
M3  - Article
SP  - 303
EP  - 306
SN  - 00368075
AB  - Intracellular iontophoretic injection of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase increased input resistance and decreased a delayed voltage-dependent K+ current of the type B photoreceptor in the nudibranch Hermissenda crassicornis to a greater extent than an early, rapidly inactivating K+ current (IA). This injection also enhanced the long-lasting depolarization of type B cells after a light step. These findings suggest the involvement of cyclic adenosine monophosphate-dependent phosphorylation in the differential regulation of photoreceptor K+ currents particularly during illumination. On the other hand, conditioning-induced changes in IA may also be regulated by a different type of phosphorylation (for example, Ca2+-dependent). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712553; ALKON, DANIEL L. 1; ACOSTA-URQUIDI, JUAN 1; OLDS, JAMES 1; KUZMA, GREGORY; NEARY, JOSEPH T. 1; Affiliations: 1: Section on Neural Systems, Laboratory of Biophysics, National Institutes of Health, Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 1/21/1983, Vol. 219 Issue 4582, p303; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - MENDELSON, WALLACE B.
AU  - CAIN, MICHAEL
AU  - COOK, JAMES M.
AU  - PAUL, STEVEN M.
AU  - SKOLNICK, PHIL
T1  - A Benzodiazepine Receptor Antagonist Decreases Sleep and Reverses the Hypnotic Actions of Flurazepam.
JO  - Science
JF  - Science
Y1  - 1983/01/28/
VL  - 219
IS  - 4583
M3  - Article
SP  - 414
EP  - 416
SN  - 00368075
AB  - The benzodiazepine receptor antagonist 3-hydroxymethyl-p-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency ift the rat. Furthermore, at a low dose that by itselfdoes not affect sleep, 3-hydroxymethyl-f-carboline blocks sleep induction by a large dosf of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712596; MENDELSON, WALLACE B. 1; CAIN, MICHAEL 2; COOK, JAMES M. 2; PAUL, STEVEN M. 3; SKOLNICK, PHIL 4; Affiliations: 1: Adult Psychiatry Branch and Unit on Sleep Studies, Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Chemistry, University of Wisconsin, Milwaukee 53201; 3: Neuroscience Branch, National Institute of Mental Health; 4: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 1/28/1983, Vol. 219 Issue 4583, p414; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Buchsbaum, Monte S.
AU  - Haier, Richard J.
T1  - PSYCHOPATHOLOGY: BIOLOGICAL APPROACHES.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1983/02//
VL  - 34
IS  - 1
M3  - Article
SP  - 401
PB  - Annual Reviews Inc.
SN  - 00664308
N1  - Accession Number: 11267640; Buchsbaum, Monte S. 1 Haier, Richard J. 2,3; Affiliation:  1: Section on Clinical Psychophysiology, National  Institute of Mental Health, Bethesda, Maryland 20205.  2: Section of  Psychiatry and Human Behavior, Brown University.  3: Butler Hospital, Providence, Rhode Island 02906.; Source Info: 1983, Vol. 34 Issue 1, p401; Number of Pages: 30p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bolen, J. B.
AU  - Tribble, J. L.
T1  - Delayed hypersensitivity to <em>Staphylococcus aureus</em> in mice: kinetics of induction.
JO  - Immunology
JF  - Immunology
Y1  - 1983/02//
VL  - 48
IS  - 2
M3  - Article
SP  - 239
EP  - 246
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The induction of systemic delayed hypersensitivity to Staphylococcus aureus is dependent on a minimum of two weekly injections of viable bacteria. In vitro lymphocyte stimulation studies show that the spleen acts as a repository for the immunogen-responsive lymphocytes associated with DH. To evaluate the kinetics of induction, mice were given one to three weekly injections of viable S. aureus and the weights, lymphocyte numbers, DNA synthesis and lymphocyte immunogen reactivity of the draining lymph node (DLN), contralateral lymph node (CLN), and spleen (SP) were determined at days 7, 14 and 21 post injection. The staphylococcal immunogens included whole cell sonicate, cell wall, cell membrane, protein A, lipoteichoic acid, teichoic acid and purified membrane proteins. A single injection resulted in an increase in organ weight, lymphocyte numbers and DNA synthesis of the DLN. This was accompanied by lymphocyte responsiveness to all immunogens. There was an increase in spleen weight and lymphocyte numbers without an appreciable increase in DNA synthesis. Spleen lymphocytes showed no increase in immunogen responsiveness. A second injection maintained the increased weight, lymphocyte numbers and DNA synthesis of the DLN but resulted in a suppression of lymphocyte responsiveness to all immunogens. Splenic lymphocytes showed in vitro reactivity to all immunogens. This was accompanied by an increase in lymphocytes and mitogenic responsiveness without in vivo mitosis. The third injection maintained suppression of DLN cells and further stimulated those of the spleen. The splenic lymphocytes were hyper-reactive to B-lymphocyte and T-lymphocyte mitogens and showed an increased rate of DNA synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DELAYED hypersensitivity
KW  - CELLULAR immunity
KW  - STAPHYLOCOCCUS aureus
KW  - DNA synthesis
KW  - LYMPHOCYTES
KW  - BACTERIOLOGY
N1  - Accession Number: 13991090; Bolen, J. B. 1 Tribble, J. L. 2; Affiliation:  1: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland  2: Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana, U.S.A.; Source Info: Feb83, Vol. 48 Issue 2, p239; Subject Term: DELAYED hypersensitivity; Subject Term: CELLULAR immunity; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: DNA synthesis; Subject Term: LYMPHOCYTES; Subject Term: BACTERIOLOGY; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Breathnach, Stephen M.
AU  - Melrose, Susan M.
AU  - Bhogal, Balbir
AU  - De Beer, Frederick C.
AU  - Black, Martin M.
AU  - Pepys, Mark B.
T1  - Immunohistochemical Studies of Amyloid P Component Distribution in Normal Human Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/02//
VL  - 80
IS  - 2
M3  - Article
SP  - 86
EP  - 90
SN  - 0022202X
AB  - The distribution of amyloid P component (AP) in normal human skin was investigated by a light and electron microscopic immunoperoxidase technique, using antibodies to serum amyloid P component (SAP). AP, or an immunologically cross-reactive protein, was found to be specifically localized to the microfibrils of papillary oxytalan fibers and to the peripheral microfibrillar mantle surrounding the elastin core of mature elastic fibers in the reticular dermis; collagen fibers were not stained with anti-SAP, AP was not detected in the dermal-epidermal basement membrane or in the basement membranes surrounding dermal papillary blood vessels and eccrine structures. These findings, which establish the detailed distribution of normal tissue AP in the skin, provide a basis for further studies of the function and behavior of this protein in health and disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMYLOID
KW  - SKIN
KW  - IMMUNOHISTOCHEMISTRY
KW  - IMMUNOGLOBULINS
KW  - COLLAGEN
KW  - IMMUNOENZYME technique
N1  - Accession Number: 12531608; Breathnach, Stephen M. 1 Melrose, Susan M. 2 Bhogal, Balbir 3 De Beer, Frederick C. 4 Black, Martin M. 3 Pepys, Mark B. 4; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205.  2: Department of Histopathology, Royal Postgraduate Medical School London, U. K.  3: Institute of Dermatology, St. John's Hospital for Diseases of Skin, London.  4: Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School London, U. K.; Source Info: Feb83, Vol. 80 Issue 2, p86; Subject Term: AMYLOID; Subject Term: SKIN; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: IMMUNOGLOBULINS; Subject Term: COLLAGEN; Subject Term: IMMUNOENZYME technique; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12531608
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SPECTOR, ILAN
AU  - SHOCHET, NAVA R.
AU  - KASHMAN, YOEL
AU  - GROWEISS, AMIRAM
T1  - Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells.
JO  - Science
JF  - Science
Y1  - 1983/02/04/
VL  - 219
IS  - 4584
M3  - Article
SP  - 493
EP  - 495
SN  - 00368075
AB  - Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recentlyfrom the Red Sea sponge Latrunculia magnifica. The effects of the se toxins on cultured mouse neuroblastoma andfibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712628; SPECTOR, ILAN 1; SHOCHET, NAVA R. 1; KASHMAN, YOEL 2; GROWEISS, AMIRAM 2; Affiliations: 1: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Departmenzt of Organic Chemistry, Tel-Aviv University, Tel-Aviv, Israel; Issue Info: 2/ 4/1983, Vol. 219 Issue 4584, p493; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - JOSEPHS, STEVEN F.
AU  - FAVERA, RICCARDO DALLA
AU  - GELMANN, EDWARD P.
AU  - GALLO, ROBERT C.
AU  - WONG-STAAL, FLOSSIE
T1  - 5' Viral and Human Cellular Sequences Corresponding to the Transforming Gene of Simian Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1983/02/04/
VL  - 219
IS  - 4584
M3  - Article
SP  - 503
EP  - 505
SN  - 00368075
AB  - The 5' nucleotide sequences of the transforming gene of simian sarcoma virus (v-sis) and its human cellular homolog (c-sis) were compared. A short homology was found between helper virus and cellular DNA sequences at the junction of v-sis and c-sis, which may have had a role in the original recombination event leading to the generation of simian sarcoma virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712632; JOSEPHS, STEVEN F. 1; FAVERA, RICCARDO DALLA 1; GELMANN, EDWARD P. 1; GALLO, ROBERT C. 1; WONG-STAAL, FLOSSIE 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/ 4/1983, Vol. 219 Issue 4584, p503; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Weiher, Hans
AU  - König, Monika
AU  - Gruss, Peter
T1  - Multiple Point Mutations Affecting the Simian Virus 40 Enhancer.
JO  - Science
JF  - Science
Y1  - 1983/02/11/
VL  - 219
IS  - 4585
M3  - Article
SP  - 626
EP  - 631
SN  - 00368075
N1  - Accession Number: 84712645; Weiher, Hans 1; König, Monika 2; Gruss, Peter 3; Affiliations: 1: Postdoctoral fellow, Institute of Microbiology, University of Heidelberg; 2: Microbiologist, Laboratory of Molecular Virology, National Institutes of Health, Bethesda, Maryland 20205; 3: Visiting scientist, Laboratory of Molecular Virology, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/11/1983, Vol. 219 Issue 4585, p626; Number of Pages: 6p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - MUSCHEL, RUTH J.
AU  - KHOURY, GEORGE
AU  - LEBOWITZ, PAUL
AU  - KOLLER, RICHARD
AU  - DHAR, RAVI
T1  - The Human c-ras1H Oncogene: A Mutation in Normal and Neoplastic Tissue from the Same Patient.
JO  - Science
JF  - Science
Y1  - 1983/02/18/
VL  - 219
IS  - 4586
M3  - Article
SP  - 853
EP  - 856
SN  - 00368075
AB  - The c-ras1H oncogene can be distinguished from its normal cellular counterpart by the loss of a restriction endonuclease site. This sequence alteration is the basis of a rapid screening methodfor the presence of this oncogene. DNA'sfrom 34 individuals were screened by this method, and all were homozygous for the normal allele. In contrast, DNA from a patient's bladder tumor, as well as DNA from his normal bladder and leukocytes, were heterozygous at that restriction endonuclease site. Further restriction enzyme mapping pinpointed the change in the mutant allele as being one of two nucleotides, either of which would change the 12th amino acid (glycine) in the normal c-ras1H gene product. Point mutations in the codonfor this amino acid have previously been described in a bladder tumor cell line and in the viral oncogene v-rasH. These results indicate that the patient carried a cras, H oncogene in his germ line, raising the possibility that the c-ras1H oncogene confers a predisposition to neoplasia. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712710; MUSCHEL, RUTH J. 1; KHOURY, GEORGE 1; LEBOWITZ, PAUL 2; KOLLER, RICHARD 3; DHAR, RAVI 3; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Medicine, Yale University Medical School, New Haven, Connecticut 06510; 3: Laboratory of Molecular Virology, National Cancer Institute; Issue Info: 2/18/1983, Vol. 219 Issue 4586, p853; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - POPOVIC, M.
AU  - SARIN, P. S.
AU  - ROBERT-GURROFF, M.
AU  - KALYANARAMAN, V. S.
AU  - MANN, D.
AU  - MINOWADA, J.
AU  - GALLO, R. C.
T1  - Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus).
JO  - Science
JF  - Science
Y1  - 1983/02/18/
VL  - 219
IS  - 4586
M3  - Article
SP  - 856
EP  - 859
SN  - 00368075
AB  - Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712711; POPOVIC, M. 1; SARIN, P. S. 1; ROBERT-GURROFF, M. 1; KALYANARAMAN, V. S. 2; MANN, D. 3; MINOWADA, J. 4; GALLO, R. C. 5; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland 20895; 3: Division of Cancer Biology and Diagnosis, National Cancer Institute; 4: Department of Immunology, Roswell Park Memorial Institute, Buffalo, New York 14263; 5: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 2/18/1983, Vol. 219 Issue 4586, p856; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PRESSER, HARRIET B.
AU  - CAIN, VIRGINIA S.
T1  - Shift Work Among Dual-Earner Couples with Children.
JO  - Science
JF  - Science
Y1  - 1983/02/18/
VL  - 219
IS  - 4586
M3  - Article
SP  - 876
EP  - 879
SN  - 00368075
AB  - In a 1980 sample of U.S. nonfarm households with children and with both spouses employed full time, one-third of the couples included at least one spouse who worked other than a regular day shift. In about one-tenth of the couples the spouses worked entirely different shifts with no overlap in hours. These findings are linked to an earlier study which showed a high prevalence of child care by employed fathers whose wives were employed in certain occupations. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712719; PRESSER, HARRIET B. 1; CAIN, VIRGINIA S. 2; Affiliations: 1: Department of Sociology, University of Maryland, College Park 20742; 2: Department of Sociology, University of Maryland, and Center, Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 2/18/1983, Vol. 219 Issue 4586, p876; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - OLDHAM, ROBERT R.
T1  - Toxic Effects of Interferon.
JO  - Science
JF  - Science
Y1  - 1983/02/25/
VL  - 219
IS  - 4587
M3  - Article
SP  - 902
EP  - 902
SN  - 00368075
N1  - Accession Number: 84712722; OLDHAM, ROBERT R. 1; Affiliations: 1: Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Marylaind 21701; Issue Info: 2/25/1983, Vol. 219 Issue 4587, p902; Number of Pages: 6/7p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - DALLA-FAVERA, RICCARDO
AU  - MARTINOTII, STEFANO
AU  - GALLO, ROBERT C.
AU  - ERIKSON, JAN
AU  - CROCE, CARLO M.
T1  - Translocation and Rearrangements of the c-myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas.
JO  - Science
JF  - Science
Y1  - 1983/02/25/
VL  - 219
IS  - 4587
M3  - Article
SP  - 963
EP  - 967
SN  - 00368075
AB  - The locus for the cellular myc (c-myc) oncogene in humans is located on the region of chromosome 8 that is translocated to chromosome 14 in cellsfrom most undifferentiated B-cell lymphomas. It is shown in this study that the c-myc locus is rearranged in S out of 15 cell lines from patients with undifferentiated B-cell lymphomas, and that the rearrangement involves a region at the 5' side of an apparently intact c-myc gene. In at least three patients, this rearranged region appears to contain immunoglobulin heavy chain μsequences that are located on chromosome 14. The data indicate that this region contains the crossover point between chromosomes 8 and 14. The break point can occur at different positions on both chromosomes among individual cell lines. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712752; DALLA-FAVERA, RICCARDO 1; MARTINOTII, STEFANO 1; GALLO, ROBERT C. 1; ERIKSON, JAN 2; CROCE, CARLO M. 2; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; Issue Info: 2/25/1983, Vol. 219 Issue 4587, p963; Number of Pages: 5p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - MUKHERJEE, DIANE C.
AU  - AGRAWAL, ARUN K.
AU  - MANJUNATH, RAMANATHAPURAM
AU  - MUKHERJEE, ANIL B.
T1  - Suppression of Epididymal Sperm Antigenicity in the Rabbit by Uteroglobin and Transglutaminase in vitro.
JO  - Science
JF  - Science
Y1  - 1983/02/25/
VL  - 219
IS  - 4587
M3  - Article
SP  - 989
EP  - 991
SN  - 00368075
AB  - There is evidence that the mammalian female genital tract is capable oJ responding immunologically when challenged with alloantigens. The antigenic properties of male gametes have been well delineated. However, it is only ralrely that a female mammal ever responds immunologically to the male gametic antigens as a result of coitus. When a proposed mechanism of suppression of antigenicity of epididymal spermatozoa was tested experimentally, the results indicated that two proteins (uteroglobin and transglutaminase) present in the prostate may be responsible for suppressing sperm antigenicity in the rabbit. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84712764; MUKHERJEE, DIANE C. 1,2; AGRAWAL, ARUN K. 1,2; MANJUNATH, RAMANATHAPURAM 1,2; MUKHERJEE, ANIL B. 1,2; Affiliations: 1: Section on Molecular and Developmental Genetics, Pregnancy Research Branch; 2: National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 2/25/1983, Vol. 219 Issue 4587, p989; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - NEWS
AU  - Beebe, Gilbert W.
AU  - Yankuer, Alfred
T1  - Long-Term Follow-Up Is a Problem.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1983/03//
VL  - 73
IS  - 3
M3  - Editorial
SP  - 245
EP  - 248
PB  - American Public Health Association
SN  - 00900036
AB  - This article focuses on problems in conducting medical follow-up and epidemiologic studies in the U.S. It is difficult and impractical to link events in the life hisotry of an individual in order to advance medical science, despite of the allocation of medical care funds and advances in technology. Difficulties may be experienced by researchers of long-term follow-up studies, especially if outcomes and events are at issue. Researchers must have access to individuals involved in order to obtain responses to a questionnaire or interview or to perform spoecific examination procedure.
KW  - MEDICAL research
KW  - EPIDEMIOLOGY -- Research
KW  - MEDICAL sciences
KW  - OUTCOME assessment (Medical care)
KW  - MEDICAL technology
KW  - UNITED States
N1  - Accession Number: 4948743; Beebe, Gilbert W. 1 Yankuer, Alfred; Affiliation:  1: Expert Scientist, Clinical Epidemiology Branch, National Cancer Institute, Room 5A21 Landow Building, Bethesda, MD 20205; Source Info: Mar1983, Vol. 73 Issue 3, p245; Subject Term: MEDICAL research; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: MEDICAL sciences; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL technology; Subject Term: UNITED States; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Madans, Jennifer
AU  - Kleinman, Joel C.
AU  - Cornoni-Huntley, Joan
T1  - The Relationship between Hip Fracture and Water Fluoridation: An Analysis of National Data.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1983/03//
VL  - 73
IS  - 3
M3  - Article
SP  - 296
EP  - 298
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Data from the 1973-1977 National Health Interview Surveys were used to determine whether water fluoridation prevents hip fractures related to osteoporosis, No protective effect was found for fluoride levels of 0.7 ppm the level recommended for the prevention of dental caries There are some indications that higher concentrations of fluoride might have a protective effect for groups with a high incidence of osteoporosis. However. no determination of the actual levels needed or the possible adverse effects of high water fluoride levels could be made. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SURVEYS
KW  - WATER fluoridation
KW  - FRACTURES
KW  - PELVIC bones
KW  - OSTEOPOROSIS
N1  - Accession Number: 4948784; Madans, Jennifer 1 Kleinman, Joel C. 1 Cornoni-Huntley, Joan 2; Affiliation:  1: Division of Analysis, National Center for Health Statistics, FCB#2, Room 2-27, 3700 East-West Highway, Hyattsville, MD 20782  2: National Institute on Aging; Source Info: Mar1983, Vol. 73 Issue 3, p296; Subject Term: SURVEYS; Subject Term: WATER fluoridation; Subject Term: FRACTURES; Subject Term: PELVIC bones; Subject Term: OSTEOPOROSIS; Number of Pages: 3p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Roder, J. C.
AU  - Todd, R. F.
AU  - Rubin, J. P.
AU  - Haliotis, Tina
AU  - Helfand, S. L.
AU  - Werkmeister, J.
AU  - Pross, H. F.
AU  - Boxer, L. A.
AU  - Schlossman, S. F.
AU  - Fauci, A. S.
T1  - The Chediak-Higashi gene in humans. III. Studies on the mechanisms of NK impairment.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1983/03//
VL  - 51
IS  - 3
M3  - Article
SP  - 359
EP  - 368
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Lymphocytes from six Chediak Higashi (CH) patients were markedly depressed in their ability to lyse tumour cell targets in both 51Cr release and single cell cytotoxicity assays. The frequency of lymphocytes bearing the OKM1 marker and the frequency of T3+, T4+, T8+, la-, Mol+, Mo2+ and BI+ cells was normal among sheep erythrocyte rosetting (E+ ) and non-resetting (E-) peripheral blood leucocytes analysed by flow cytofluorography. Cells expressing the NK shared markers. OKMI mac-1, FcR, and the characteristic large granular lymphocyte (LGL) morphology of NK cells were also present in normal numbers in the highly enriched NK fraction separated on Percoll density gradients. This fraction did not contain detectable numbers of cells expressing the Mo2 marker of human monocytes. Therefore most of the cells stained by monoclonal OKMI and mac-1 in this fraction are likely NK cells, rather than monocytes. and we conclude that the size of the NK pool in CH patients is probably normal. The capacity of CH lymphocytes to recognize anti bind to tumour cells was also normal as was the subsequent burst at oxygen intermediates produced by the NK cells in a chemiluminenscence assay We have shown elsewhere that O2 generation is directly involved in activating subsequent steps in the NK cytolytic pathway. These results suggest that NK cells in CH patients are present in normal frequency but are blocked at some post-recognition, post-activation step in the cytolytic pathway subsequent to the burst of oxygen intermediates but preceding the lethal hit. [ABSTRACT FROM AUTHOR]
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KW  - LYMPHOCYTES
KW  - TUMORS
KW  - KILLER cells
KW  - SHEEP as laboratory animals
KW  - ERYTHROCYTES
KW  - LEUCOCYTES
N1  - Accession Number: 16253512; Roder, J. C. 1,2 Todd, R. F. 3 Rubin, J. P. 1,2,4 Haliotis, Tina 1,2 Helfand, S. L. 1,2 Werkmeister, J. 1,2,4 Pross, H. F. 1,2,4 Boxer, L. A. 5 Schlossman, S. F. 3 Fauci, A. S. 6; Affiliation:  1: Department of Microbiology,Immunology, Queens University, Kingston, Ontario, Canada  2: Department of Immunology, Queens University, Kingston, Ontario, Canada  3: Division of Tumor Immunology, Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts  4: Department of Radiation Oncology, Queens University, Kingston, Ontario, Canada  5: Division of Paediatric Hematology Oncology, Indiana University, School of Medicine, James Witcomb Riley Hospital for Children, Indianapolis, Indiana  6: Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Mar1983, Vol. 51 Issue 3, p359; Subject Term: LYMPHOCYTES; Subject Term: TUMORS; Subject Term: KILLER cells; Subject Term: SHEEP as laboratory animals; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jahn, Claus E.
AU  - Osborne Jr., James C.
AU  - Schaefer, Ernst J.
AU  - Brewer Jr, H, Bryan
T1  - Activation of the Enzymic Activity of Hepatic Lipase by Apolipoprotein A-II.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/03//3/1/83
VL  - 131
IS  - 1
M3  - Article
SP  - 25
EP  - 29
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Human post-heparin plasma contains two major lipases, lipoprotein lipase and hepatic lipase. Lipoprotein lipase has been investigated extensively and in the presence of a specific activator, apolipoprotein C-II, is of major importance in modulating the hydrolysis of triacylglycerol rich lipoprotein particles in plasma. The metabolic function and regulation of hepatic lipase is less well established. We have reported previously that apolipoprotein A-II (apoA-II) in vitro increased the activity of hepatic lipase by 3.6-fold [Jahn et al. (198l) FEBS Lett. 131, 366–368]. We have extended these studies and report here the effects of normal plasma, very low density, low density and high density lipoproteins (VLDL, LDL and HDL) and apolipoproteins A-I, A-II, C-I, C-II and C-III on hepatic lipase enzymic activity. Normal plasma and HDL activated hepatic lipase by 255 ± 53% (n = 9) and 288 ± 55% (n = 7) respectively, whereas VLDL inhibited hepatic lipase to 25% and LDL did not affect hepatic lipase enzymic activity (n = 7). Isolated apoA-I, apoC-I, apoC-II, and apoC-III inhibited hepatic lipase enzymic activity to 25 ± 8% (n = 5), 25 ± 15% (n = 5), 23 ± 7% (n = 5) and 13 ± 10% (n = 5) of the basal level. ApoA-II recombined with HDL lipids activated by 273 ± 42% (n = 5) whereas apoC-III recombined with HDL lipids inhibited hepatic lipase to 30% of basal activity. Activation of hepatic lipase by apoA-II was dependent on temperature and pH, with maximal activation (5.75-fold over basal levels) occurring at pH 7.5 and 37°C. The addition of lipid-free apoA-11 10 min after the hydrolysis of triacylglycerol by hepatic lipase had begun resulted in an increase in rate from 1.9 nmol min-1 ml-1 to 7.0 nmol min-1 ml-1. The rate observed by the addition of apoA-II before the start of the reaction was 9.5 nmol min-1 ml-1. These results are consistent with the concept that apoA-II modulates the enzymic activity of hepatic lipase, and may play a role in vivo in the regulation of hepatic lipase activity and HDL lipoprotein metabolism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPARIN
KW  - LIPASES
KW  - LIPOPROTEIN lipase
KW  - APOLIPOPROTEINS
KW  - HYDROLYSIS
KW  - LIPOPROTEINS
N1  - Accession Number: 15818091; Jahn, Claus E. 1 Osborne Jr., James C. 1 Schaefer, Ernst J. 1 Brewer Jr, H, Bryan; Affiliation:  1: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 3/1/83, Vol. 131 Issue 1, p25; Subject Term: HEPARIN; Subject Term: LIPASES; Subject Term: LIPOPROTEIN lipase; Subject Term: APOLIPOPROTEINS; Subject Term: HYDROLYSIS; Subject Term: LIPOPROTEINS; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rousset, Bernard
AU  - Bernier-Valentin, Françoise
AU  - Wolff, Jan
AU  - Roux, Bernard
T1  - Alterations in Tubulin Immunoreactivity; Relation to Secondary Structure.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/03//3/1/83
VL  - 131
IS  - 1
M3  - Article
SP  - 31
EP  - 39
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The immunoreactivity of tubulin varies with the conditions of preparation and storage of the protein. Four different antisera to tubulin detected less than or about 10% of the tubulin present in purified rat brain microtubule protein either immediately after preparation or after storage at -196°C. Addition of salt to the storage buffer led to a partial recovery of immunoreactivity. After storage at -20°C or after transfer from -196°C to -20°C, the recovery of tubulin immunoreactivity varied with the concentration of microtubule protein. At concentrations higher than 2.0–2.5 mg/ml, tubulin remained non-immunoreactive. On decreasing the protein concentration, there was a progressive recovery of the immunoreactivity. Addition of salt to the storage buffer led to a full recovery whatever the protein concentration. Storage in 2 M glycerol prevented immunoreactivity in all the conditions. Phosphocellulose chromatography of microtubule protein lacking immunoreactivity yielded a pure tubulin that was fully immunoassayable. Transfer of microtubule protein from -20°C to -196°C led to a significant decrease of the amount of immunoassayable tubulin indicating that the alterations of tubulin immunoreactivity are reversible. Immunoreactivity of tubulin present in freshly prepared crude rat brain 100000 x g supernatant was also incompletely immunoreactive and increased after freezing at -20°C. Circular dichroic spectra showed that freezing at -20°C decreased the content of a helix from 41% (at -196°C) to 28% in purified microtubule protein. The percentage a helix was low in buffers of high ionic strength and high in the presence of glycerol irrespective of the storage temperature. Thus, the a helix content showed an inverse relationship to immunoreactivity and the availability of antigenic sites seems to be related to the conformation of tubulin. Although the ability of microtubule protein to polymerize was maintained after storage at -196°C and decreased after storage at -20°C, there was no direct relationship between immunoreactivity and the polymerization properties of tubulin. Our results show that care should be taken in the preparation of tubulin samples to be assayed by immunological techniques. Glycerol, which is often used to prepare and store tubulin, prevents the ability of tubulin to react with specific antibodies. Alterations of the availability of antigenic sites, observed in the presence of glycerol or salt or after freezing, seem to be related to changes of the conformation of tubulin. [ABSTRACT FROM AUTHOR]
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KW  - TUBULINS
KW  - PROTEINS
KW  - IMMUNE serums
KW  - IMMUNE response
KW  - IMMUNOGLOBULINS
KW  - MICROTUBULES
N1  - Accession Number: 15818094; Rousset, Bernard 1 Bernier-Valentin, Françoise 1 Wolff, Jan 2 Roux, Bernard 3; Affiliation:  1: Groupe de Physiopathologie Endocrinienne, Unité 197 de l'Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Alexis Carrel, Rue Guillaume Paradin, F-69372 Lyon-Cedex-2, France  2: National Institutes of Health, 900 Rockville Pike, Bethesda, MD, USA 20205  3: Laboratoire de Physico-Chimie Biologique, Université Claude, Bernard, 43, boulevard du 11 Novembre 1918, F-69100 Villeurbanne, France; Source Info: 3/1/83, Vol. 131 Issue 1, p31; Subject Term: TUBULINS; Subject Term: PROTEINS; Subject Term: IMMUNE serums; Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULINS; Subject Term: MICROTUBULES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Breslow, N.E.
AU  - Lubin, J. H.
AU  - Marek, P.
AU  - Langholz, B.
T1  - Multiplicative Models and Cohort Analysis.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1983/03//
VL  - 78
IS  - 381
M3  - Article
SP  - 1
SN  - 01621459
AB  - Three methods of cohort analysis are presented for a statistical model wherein the explanatory or exposure variables act multiplicatively on age x calendar year specific death rates. The first method, which assumes that the baseline rates are known from national vital statistics, is a multiple regression analysis of the standardized mortality ratio. The second method is a variant of Cox's proportional hazards analysis in which the baseline rates are treated as unknown nuisance parameters. The third method consists of case-control sampling from the risk sets formed in the course of applying Cox's model. It requires substantially less computation than do the other two. In illustrative analysis of respiratory cancer deaths among a cohort of smelter workers, all three approaches yield roughly equivalent estimates of the relative risk associated with arsenic exposure. The discussion centers on the tradeoff between efficiency and bias in the selection of a particular method of analysis, and on practical issues that arise in applications. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICS
KW  - MULTIVARIATE analysis
KW  - REGRESSION analysis
KW  - SAMPLING (Statistics)
KW  - MATHEMATICAL models
KW  - COHORT analysis
KW  - MORTALITY
KW  - HAZARDS
KW  - Case-control studies
KW  - Cohort studies
KW  - Efficiency
KW  - Nonlinear regression
KW  - Proportional hazards
KW  - Proportional mortality ratio
KW  - Standardized mortality ratio.
N1  - Accession Number: 4607597; Breslow, N.E. 1; Lubin, J. H. 2; Marek, P. 3; Langholz, B.; Affiliations: 1: Professor, Department of Biostatistics SC-32, University of Washington, Seattle, WA 98195.; 2: The Environmental Epidemiology Branch, National Cancer Institute, 3C07 Landow Bldg., Bethesda, MD 20205.; 3: Scientific Programmer, the Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104.; Issue Info: Mar1983, Vol. 78 Issue 381, p1; Thesaurus Term: STATISTICS; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: REGRESSION analysis; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL models; Subject Term: COHORT analysis; Subject Term: MORTALITY; Subject Term: HAZARDS; Author-Supplied Keyword: Case-control studies; Author-Supplied Keyword: Cohort studies; Author-Supplied Keyword: Efficiency; Author-Supplied Keyword: Nonlinear regression; Author-Supplied Keyword: Proportional hazards; Author-Supplied Keyword: Proportional mortality ratio; Author-Supplied Keyword: Standardized mortality ratio.; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Brown, Kenneth G.
T1  - Sub-Balanced Data and the Mixed Analysis of Variance.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1983/03//
VL  - 78
IS  - 381
M3  - Article
SP  - 162
SN  - 01621459
AB  - In the mixed model, it is well known that balanced data are a sufficient condition for an ANOVA with terms that are independent multiples of chi-squared variables (called a proper ANOVA). In this article a weaker condition, which is both necessary and sufficient, is determined and shown to be equivalent to what is defined here as sub-balanced random effects, a condition easily checked in practice. The usual method of generating an ANOVA by fitting sums of squares for a given ordering of the effects in the model is sometimes inadequate with sub-balanced data, requiring instead a spectral decomposition of the covariance matrix. An example is given. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANALYSIS of variance
KW  - MATHEMATICAL models
KW  - PROBABILITY theory
KW  - STATISTICS
KW  - VARIABLES (Mathematics)
KW  - DECOMPOSITION (Mathematics)
KW  - RANDOM vibration
KW  - MATRICES
KW  - Analysis of variance
KW  - Balanced data
KW  - Mixed model.
KW  - Sub-balanced data
KW  - Variance components
N1  - Accession Number: 4607873; Brown, Kenneth G. 1; Affiliations: 1: Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 277089.; Issue Info: Mar1983, Vol. 78 Issue 381, p162; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICS; Subject Term: VARIABLES (Mathematics); Subject Term: DECOMPOSITION (Mathematics); Subject Term: RANDOM vibration; Subject Term: MATRICES; Author-Supplied Keyword: Analysis of variance; Author-Supplied Keyword: Balanced data; Author-Supplied Keyword: Mixed model.; Author-Supplied Keyword: Sub-balanced data; Author-Supplied Keyword: Variance components; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Abbott, Robert D.
T1  - Statistics for Biologists/ Statistical Methods in Biology (2nd ed.) (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1983/03//
VL  - 78
IS  - 381
M3  - Book Review
SP  - 207
SN  - 01621459
AB  - Reviews two books. "Statistics for Biologists," by D.J. Finney; "Statistical Methods in Biology," 2nd ed., by N.T.J. Bailey.
KW  - NONFICTION
KW  - FINNEY, D. J.
KW  - BAILEY, N. T. J.
KW  - STATISTICS for Biologists (Book)
KW  - STATISTICAL Methods in Biology (Book)
N1  - Accession Number: 4608189; Abbott, Robert D. 1; Affiliations: 1: National Heart, Lung, And Blood Institute.; Issue Info: Mar1983, Vol. 78 Issue 381, p207; Subject Term: NONFICTION; Reviews & Products: STATISTICS for Biologists (Book); Reviews & Products: STATISTICAL Methods in Biology (Book); People: FINNEY, D. J.; People: BAILEY, N. T. J.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Hoel, David G.
AU  - Kaplan, Norman L.
AU  - Anderson, Marshall W.
T1  - Implication of Nonlinear Kinetics on Risk Estimation in Carcinogenesis.
JO  - Science
JF  - Science
Y1  - 1983/03/04/
VL  - 219
IS  - 4588
M3  - Article
SP  - 1032
EP  - 1037
SN  - 00368075
N1  - Accession Number: 84712775; Hoel, David G. 1; Kaplan, Norman L. 2; Anderson, Marshall W. 3; Affiliations: 1: Director, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: A mathematician, Statistics and Biomathematics Branch, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 3: A Senior Research Scientist, Molecular and Comparative Pharmacology Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park; Issue Info: 3/ 4/1983, Vol. 219 Issue 4588, p1032; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SPORN, MICHAEL B.
AU  - ROBERTS, ANITA B.
AU  - SHULL, JAMES H.
AU  - SMITH, JOSEPH M.
AU  - WARD, JERROLD M.
AU  - SODEK, JARO
T1  - Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in vivo.
JO  - Science
JF  - Science
Y1  - 1983/03/18/
VL  - 219
IS  - 4590
M3  - Article
SP  - 1329
EP  - 1331
SN  - 00368075
AB  - Transforming growth factors, which are polypeptides that induce the transformed phenotype in nonneoplastic cells, have been isolated in bulk amounts from bovine salivary gland and kidney. In experiments in which wound healing chambers were implanted subcutaneously in the backs of rats, these bovine transforming growth factors accelerated the accumulation of total protein, collagen, and DNA in treated chambers. These studies thus show an effect of an isolated transforming growth factor in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84712887; SPORN, MICHAEL B. 1; ROBERTS, ANITA B. 1; SHULL, JAMES H. 1; SMITH, JOSEPH M. 1; WARD, JERROLD M. 1; SODEK, JARO 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland, 20205; 2: National Institute of Dental Research, Bethesda, Maryland, 20205; Issue Info: 3/18/1983, Vol. 219 Issue 4590, p1329; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Schlesinger, Herbert J.
AU  - Mumford, Emily
AU  - Glass, Gene V.
AU  - Patrick, Cathleen
AU  - Sharfstein, Steven
T1  - Mental Health Treatment and Medical Care Utilization in a Fee-For-Service System: Outpatient Mental Health Treatment Following the Onset of a Chronic Disease.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1983/04//
VL  - 73
IS  - 4
M3  - Article
SP  - 422
EP  - 429
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Charges for medical services of persons covered by the Blue Cross/Blue Shield Federal Employees Program from 1974 through 1978 who were first diagnosed as having one of four chronic diseases in 1975 and within one year began mental health treatment (MHT) were compared with persons who also were firm diagnosed as having one of these diseases in 1975 but had no subsequent MHT.  In the third year following the diagnosis, those having seven to 20 MHT visits had medical charges $309 lower and those having over 21 MHT visits had medical charges $284 lower than the comparison group. The savings in medical charges over three years of the group having seven to 20 MHT visits were a function of lower use of inpatient services and roughly equaled the cost of 20 MHT visits. Outpatient mental health treatment can be included in a fee-for-service medical care system to improve the quality and appropriateness of care and, if not extensive, may also serve to lower medical care costs. (Am J Public Health 1983: 73:422-429.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL care costs
KW  - MEDICAL care
KW  - RURAL health services
KW  - CHRONIC diseases
KW  - MENTAL health
KW  - MENTAL illness -- Treatment
KW  - OUTPATIENT medical care
KW  - PUBLIC health
N1  - Accession Number: 4949454; Schlesinger, Herbert J. 1 Mumford, Emily 2 Glass, Gene V. 3 Patrick, Cathleen 4 Sharfstein, Steven 5; Affiliation:  1: Professor of Psychiatry, Department of Psychiatry, University of Colorado School of Medicines 4200 E, 9th Avenue, C-270. Denver, CO 80262 and Denver Veterans Administration Medical Center  2: Departments of Psychiatry and Preventive Medicine  3: Department of Psychiatry, University of Colorado School of Medicine  4: School of Education. University of Colorado  5: National Institute of Mental Health; Source Info: Apr1983, Vol. 73 Issue 4, p422; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care; Subject Term: RURAL health services; Subject Term: CHRONIC diseases; Subject Term: MENTAL health; Subject Term: MENTAL illness -- Treatment; Subject Term: OUTPATIENT medical care; Subject Term: PUBLIC health; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - JACOBSON, ERIC S.
AU  - STRAUS, STEPHEN E.
AU  - WHEAT, L. JOSEPH
T1  - Serologic Tests for Histoplasmosis.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1983/04//
VL  - 98
IS  - 4
M3  - Article
SP  - 560
EP  - 561
SN  - 00034819
N1  - Accession Number: 20427588; JACOBSON, ERIC S. 1; STRAUS, STEPHEN E. 2; WHEAT, L. JOSEPH 3; Source Information: Apr83, Vol. 98 Issue 4, p560; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Dean, J. H.
AU  - Luster, M. I.
AU  - Boorman, G. A.
AU  - Lauer, L. D.
AU  - Leubke, R. W.
AU  - Lawson, Lela
T1  - Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F1 mice.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1983/04//
VL  - 52
IS  - 1
M3  - Article
SP  - 199
EP  - 206
PB  - Wiley-Blackwell
SN  - 00099104
AB  - B6C3F1 mice were exposed to two congeners of benzopyrene, either the carcinogen benzo(a)pyrene (B(a)P) or the non-carcinogen benzo(e)pyrene (B(e)P, Exposure of mice to B(a)P resulted in a reduced number of IgM and IgG antibody plaque forming cells (PFC) to the T-dependent (TD) antigen SRBC and IgM PFCs to the T-independent (TI) antigen LPS. The IgM response to hapten conjugated TI antigens was examined using TNP-LPS for reactivity of less mature B cells (BI) and TNP-Ficoll for more mature B cells (B2). Exposure to B(a)P severely depressed the TNP-Ficoll PFC response by up to 77% without altering the TNP-LPS response. These data indicated that exposure to B(a)P alters differentiation and antibody production in mature B cells to both TD and B2 TI antigens. No change in PFC was observed following exposure to B(e)P. Mishell-Dutton co-cultures confirmed that B cells were affected and that T helper cells or suppressor M0 were not involved. Parameters of cell-mediated immunocompetence including delayed cutaneous hypersensitivity to KLH, allograft or tumour cell rejection and susceptibility to Listeria monocytogens were unaltered in B(a)P treated mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOSUPPRESSION
KW  - BENZOPYRENE
KW  - MICE as laboratory animals
KW  - IMMUNE response -- Regulation
KW  - LABORATORY animals
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 15985508; Dean, J. H. 1 Luster, M. I. 1 Boorman, G. A. 1 Lauer, L. D. 1 Leubke, R. W. 1 Lawson, Lela 1; Affiliation:  1: National Toxicology Program, National Institutes of Environmental Health Sciences, National Institutes of Health, North Carolina, USA.; Source Info: Apr1983, Vol. 52 Issue 1, p199; Subject Term: IMMUNOSUPPRESSION; Subject Term: BENZOPYRENE; Subject Term: MICE as laboratory animals; Subject Term: IMMUNE response -- Regulation; Subject Term: LABORATORY animals; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rölla, Gunnar
AU  - Ciardi, Joseph E.
AU  - Schultz, Sandra A.
T1  - Adsorption of glucosyltransferase to saliva coated hydroxyapatite.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1983/04//
VL  - 91
IS  - 2
M3  - Article
SP  - 112
EP  - 117
SN  - 0029845X
AB  - Glucosyltransferase (GTF) adsorbed to hydroxyapatite and to saliva costed hydroxyapatite in vitro. Several proteins which are known to be present in the "pellicle" which forms on hydroxyapatite when this mineral is exposed to whole saliva were town to stimulate or inhibit GTF. It is suggested that these proteins may interact with GTF and cause binding of the enzyme to saliva tasted hydroxyapatite. A model is suggested where GTF adsorbed to tooth surface, may induce binding of microorganisms to tooth surfaces. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SALIVARY glands
KW  - GLYCOSYLTRANSFERASES
KW  - ENZYMES
KW  - HYDROXYAPATITE
KW  - BODY fluids
KW  - PROTEINS
KW  - pellicle
KW  - plaque formation
KW  - sucrose.
N1  - Accession Number: 13176661; Rölla, Gunnar 1 Ciardi, Joseph E. 1 Schultz, Sandra A. 1; Affiliation:  1: National Caries Program, National Institute for Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: 1983, Vol. 91 Issue 2, p112; Subject Term: SALIVARY glands; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: ENZYMES; Subject Term: HYDROXYAPATITE; Subject Term: BODY fluids; Subject Term: PROTEINS; Author-Supplied Keyword: pellicle; Author-Supplied Keyword: plaque formation; Author-Supplied Keyword: sucrose.; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-42332-019
AN  - 2013-42332-019
AU  - Shore, Milton F.
T1  - Review of Unclaimed children: The failure of public responsibility to children in need of mental health services and Making policies for children: A study of the federal process.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1983/04//
VL  - 53
IS  - 2
SP  - 363
EP  - 365
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2013-42332-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Intramural Research Program, Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Community Mental Health; Foster Care; Mental Health Services; Policy Making. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Knitzer, Jane. Unclaimed children: The failure of public responsibility to children in need of mental health services=145 pp. $10.50. Children's Defense Fund, Washington, D.C; 1982. Hayes, Cheryl D. (Ed). Making policies for children: A study of the federal process=265 pp. $13.95. National Academy Press, Washington, D.C; 1982. Page Count: 3. Issue Publication Date: Apr, 1983. 
AB  - Reviews the books, Unclaimed Children: The Failure of Public Responsibility to Children in Need of Mental Health Services by Jane Knilzer (1982) and Making Policies for Children: A Study of the Federal Process edited by Cheryl D . Hayes (1982). These books address the issues of needs and social policy to meet these needs. Both agree on the importance of the role of government in developing high quality service systems for children. Jane Knitzer's book, is a remarkable documentation of the failure spelled out in its subtitle. Mental health is defined by the author broadly enough so as to encompass prevention as well as treatment, services to education, and foster care, as well as autonomous mental health services in settings such as community mental health centers. It is a reasoned , clear, unemotional work, but one which is highly committed to action for children. The volume edited by Cheryl D. Hayes, a National Research Council panel report for the Study of the Policy Formation Process, tries to conceptualize the development of federal legislation for children. Indeed, the report can be seen as an effort to try to bring some sort of rationality to what has been basically an irrational and unplanned process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community mental health
KW  - foster care
KW  - mental health services
KW  - social policy
KW  - policy making
KW  - 1983
KW  - Community Mental Health
KW  - Foster Care
KW  - Mental Health Services
KW  - Policy Making
KW  - 1983
U2  - Knitzer, Jane. (1982); Unclaimed children: The failure of public responsibility to children in need of mental health services; 145 pp. $10.50. Children's Defense Fund, Washington, D.C
U2  - Hayes, Cheryl D. (Ed). (1982); Making policies for children: A study of the federal process; 265 pp. $13.95. National Academy Press, Washington, D.C
DO  - 10.1037/h0098799
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Goldman, Robert C.
AU  - Trus, Benes L.
AU  - Leive, Loretta
T1  - Quantitative Double-Label Radiography of Two-Dimensional Protein Gels Using Color Negative Film and Computer Analysis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/04/05/
VL  - 131
IS  - 3
M3  - Article
SP  - 473
EP  - 480
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have devised a method of data collection and computer analysis which allows utilization of the resolving power of two-dimensional gel electrophoresis of proteins, in conjunction with the versatility of using two different radionuclides simultaneously. Cultures of Escherichia coli growing with exponential growth rate constants (μ) of 0.32 and 1.43 were labeled with [3H]leucine and [14C]leucine, respectively; these samples were mixed, and cell protein was separated on a two-dimensional gel. Spacial and quantitative data for both radionuclides were recorded on color negative film by radiographic exposure. Data for 14C alone were then collected photographically from the red-light- sensitive layer of the film using a red filter, while data for 3H and spillover of 14C were collected photographically from the blue-light-sensitive layer using a blue filter. These two data sets were analyzed by CINT, a computer program for analysis of two-dimensional gels, and quantitative data for 3H were calculated after determination of spillover of' 14C in a manner analogous to quantification of 3H and 14C by liquid scintillation counting. Quantitative data from over 1000 protein spots representing from 0.002% to 10 % of the total 3H or 14C, respectively, are available in a matter of hours. We have used this method to analyze the effect of growth rate and medium composition on the relative levels of individual proteins in a pathogenic strain of E. coli which contains group 111 O-antigen. As expected, the relative levels of aminoacyl-tRNA synthetases, protein chain elongation factors, ribosomal proteins, and the α- subunit of RNA polymerase are all increased with increased growth rate; the magnitude of these changes agreed with previous data derived using other strains of E coli. Alterations in the levels of other proteins identified on the two-dimensional gels could be interpreted in terms of changes in medium composition. When compared to manual data collection by excising radiolabeled proteins and quantifying 3H and 14C in a liquid scintillation counter following combustion to H2O and CO2, respectively, this new method of data collection and computer analysis increases the resolution of data collection and decreases the time involved from days to hours. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RADIOGRAPHY
KW  - PROTEINS
KW  - COMPUTER software
KW  - COMPUTER files
KW  - X-rays
KW  - ELECTROPHORESIS
KW  - TRANSFER RNA
N1  - Accession Number: 15818052; Goldman, Robert C. 1 Trus, Benes L. 1 Leive, Loretta 2; Affiliation:  1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda Maryland, USA 20205.  2: Computer Systems Laboratory, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20205.; Source Info: 4/5/83, Vol. 131 Issue 3, p473; Subject Term: RADIOGRAPHY; Subject Term: PROTEINS; Subject Term: COMPUTER software; Subject Term: COMPUTER files; Subject Term: X-rays; Subject Term: ELECTROPHORESIS; Subject Term: TRANSFER RNA; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GRAFSTROM, ROLAND C.
AU  - FORNACE JR., ALBERT J.
AU  - AUTRUP, HERMAN
AU  - LECHNER, JOHN F.
AU  - HARRIS, CURTIS C.
T1  - Formaldehyde Damage to DNA and Inhibition of DNA Repair in Human Bronchial Cells.
JO  - Science
JF  - Science
Y1  - 1983/04/08/
VL  - 220
IS  - 4593
M3  - Article
SP  - 216
EP  - 218
SN  - 00368075
AB  - Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused theformation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84713030; GRAFSTROM, ROLAND C. 1; FORNACE JR., ALBERT J. 1; AUTRUP, HERMAN 1; LECHNER, JOHN F. 1; HARRIS, CURTIS C. 1; Affiliations: 1: Laboratory of Human Carcinogenesis, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 4/ 8/1983, Vol. 220 Issue 4593, p216; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HASPEL, MARTIN V.
AU  - ONODERA, T AKASHI
AU  - PRABHAKAR, BELLUR S.
AU  - HORITA, MASAKAZU
AU  - SUZUKI, HOSHIBUMI
AU  - NOTKINS, ABNER LOUIS
T1  - Virus-Induced Autoimmunity: Monoclonal Antibodies That React with Endocrine Tissues.
JO  - Science
JF  - Science
Y1  - 1983/04/15/
VL  - 220
IS  - 4594
M3  - Article
SP  - 304
EP  - 306
SN  - 00368075
AB  - Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibodyproducing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-sp-ecific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas others recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84713066; HASPEL, MARTIN V. 1; ONODERA, T AKASHI 1; PRABHAKAR, BELLUR S. 1; HORITA, MASAKAZU 1; SUZUKI, HOSHIBUMI 1; NOTKINS, ABNER LOUIS 1; Affiliations: 1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p304; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - RICE, KENNER C.
AU  - JACOBSON, ARTHUR E.
AU  - BURKE JR., TERRENCE R.
AU  - BAJWA, BALBIR S.
AU  - STREATY, RICHARD A.
AU  - KLEE, WERNER A.
T1  - Irreversible Ligands with High Selectivity Toward 8 or FL Opiate Receptors.
JO  - Science
JF  - Science
Y1  - 1983/04/15/
VL  - 220
IS  - 4594
M3  - Article
SP  - 314
EP  - 316
SN  - 00368075
AB  - Alkylating agents that display strong selectivityfor opiate receptor types 8 or, u were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84713071; RICE, KENNER C. 1; JACOBSON, ARTHUR E. 1; BURKE JR., TERRENCE R. 1; BAJWA, BALBIR S. 1; STREATY, RICHARD A. 2; KLEE, WERNER A. 2; Affiliations: 1: Laboratory of Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p314; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOSLER, EDWARD M.
AU  - COLEMAN, JAMES L.
AU  - BENACH, JORGE L.
AU  - MASSEY, DARLENE A.
AU  - HANRAHAN, JOHN P.
AU  - BURGDORFER, WILLY
AU  - BARBOUR, ALAN G.
T1  - Natural Distribution of the Ixodes dammini Spirochete.
JO  - Science
JF  - Science
Y1  - 1983/04/15/
VL  - 220
IS  - 4594
M3  - Article
SP  - 321
EP  - 322
SN  - 00368075
AB  - Spirochetes believed to be the cause of Lyme disease were isolatedfrom white-footed mice and white-tailed deer, the preferred natural hosts of Ixodes dammini, the tick vector. Evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. Some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84713075; BOSLER, EDWARD M. 1; COLEMAN, JAMES L. 1; BENACH, JORGE L. 1; MASSEY, DARLENE A. 1; HANRAHAN, JOHN P. 2; BURGDORFER, WILLY 3; BARBOUR, ALAN G. 4; Affiliations: 1: New York State Department of Health, Health Science Center, State University of New York, Stony Brook 11794; 2: Field Service Division, Centers for Disease Control, Atlanta, Georgia 30333; 3: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 4: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p321; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HOWARD, DENNIS F.
AU  - BLUM, MURRAY S.
AU  - FALES, HENRY M.
T1  - Defense in Thrips: Forbidding Fruitiness of a Lactone.
JO  - Science
JF  - Science
Y1  - 1983/04/15/
VL  - 220
IS  - 4594
M3  - Article
SP  - 335
EP  - 336
SN  - 00368075
AB  - Expulsion of analfluidfrom the upturned abdomen was demonstrated to serve a defensive function in the thrips Bagnalliella yuccae. An allomone in the anal exudate was identified as -y-decalactone, a fruity-smelling compound that repelled potential predators. Chemical defenses may contribute to the ability of thrips to maintain large aggregations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84713082; HOWARD, DENNIS F. 1; BLUM, MURRAY S. 1; FALES, HENRY M. 2; Affiliations: 1: Department of Entomology, University of Georgia, Athens 30602; 2: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p335; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MUSCHEL, RUTH J.
AU  - KHOURY, GEORGE
AU  - LEBOWITZ, PAUL
AU  - KOLLER, RICHARD
AU  - DHAR, RAVI
T1  - Retraction of Data on the Human c-raslH Oncogene.
JO  - Science
JF  - Science
Y1  - 1983/04/15/
VL  - 220
IS  - 4594
M3  - Article
SP  - 336
EP  - 336
SN  - 00368075
N1  - Accession Number: 84713083; MUSCHEL, RUTH J. 1; KHOURY, GEORGE 1; LEBOWITZ, PAUL 2; KOLLER, RICHARD; DHAR, RAVI 3; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Medicine, Yale University Medical School, New Haven, Connecticut 06510; 3: Laboratory of Molecular Virology; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p336; Number of Pages: 1/2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Parker, Douglas A.
AU  - Parker, Elizabeth S.
AU  - Brody, Jacob A.
AU  - Schoenberg, Ronald
T1  - Alcohol Use and Cognitive Loss among Employed Men and Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1983/05//
VL  - 73
IS  - 5
M3  - Article
SP  - 521
EP  - 526
PB  - American Public Health Association
SN  - 00900036
AB  - A representative sample of 1,367 employed men and women in Detroit responded to questions about their drinking practices and then completed a cognitive test which measures abstraction abilities. Abstraction, tested while respondents were sober, decreased significantly as reported quantity of alcohol usually consumed per drinking occasion increased. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRINKING of alcoholic beverages
KW  - DRINKING behavior
KW  - GASTRONOMY
KW  - ALCOHOLISM
KW  - BINGE drinking
KW  - SUBSTANCE abuse
KW  - ALCOHOLIC beverages
KW  - ALCOHOL
KW  - DETROIT (Mich.)
N1  - Accession Number: 4945876; Parker, Douglas A. 1 Parker, Elizabeth S. 2 Brody, Jacob A. 3 Schoenberg, Ronald 4; Affiliation:  1: Professor of Human Development and Sociology, California State University, Long Beach, Long Beach, CA 90840, Bethesda, MD  2: Research Psychologist with the Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD  3: Associate Director, Epidemiology, Demography and Biometry Program, National institute on Aging, Bethesda, MD  4: Research Sociologist with the Laboratory of Socio-Environmental Studies, National Institute of Mental Health, Bethesda, MD; Source Info: May83, Vol. 73 Issue 5, p521; Subject Term: DRINKING of alcoholic beverages; Subject Term: DRINKING behavior; Subject Term: GASTRONOMY; Subject Term: ALCOHOLISM; Subject Term: BINGE drinking; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOLIC beverages; Subject Term: ALCOHOL; Subject Term: DETROIT (Mich.); NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 312140 Distilleries; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sauder, Daniel N.
AU  - Katz, Stephen I.
T1  - Strain Variation in the Induction of Tolerance by Epicutaneous Application of Trinitrochlorobenzene.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/05//
VL  - 80
IS  - 5
M3  - Article
SP  - 383
EP  - 386
SN  - 0022202X
AB  - It has been postulated that a relationship exists between the density of epidermal Langerhans cells and the capacity of the epidermis to promote the induction of contact sensitization. This postulate was developed, in part, because (1) mouse tail epidermis contains fewer ATPase-positive (presumably Langerhans) cells than does abdominal epidermis, and (2) when tails of C57B1/ 6 mice were painted with dinitrofluorobeuzene (DNFB), the mice were less sensitive than those painted on the abdomen. In addition, tail-painted mice were shown to be tolerant to subsequent attempts at sensitization with DNFB. In this study we found that by painting the tails of mice with the hapten trinitrochlorobenzene (TNCB), sensitization was induced in certain mouse strains (BALB/c, A/J, and CBA -- haplotypes H-2d, H-2n, H-2k, respectively), but tolerance resulted from painting the tails of other strains (C5'7Bl/6, C57B1/1O, and AB.Y -- haplotype H-2b). The ability to become sensitive or tolerant is not related to Langerhans cell density as detected by ATPase staining. While the mechanism for this strain difference in the induction of tolerance is unknown, tolerance induced in C57B1/6 mice is mediated in part by the generation of suppressor cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOLERATION
KW  - LANGERHANS cells
KW  - DENDRITIC cells
KW  - EPIDERMIS
KW  - MICE
KW  - TAILS
N1  - Accession Number: 12551991; Sauder, Daniel N. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May83, Vol. 80 Issue 5, p383; Subject Term: TOLERATION; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS; Subject Term: MICE; Subject Term: TAILS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12551991
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Breathnach, Stephen M.
AU  - Fox, Patricia A.
AU  - Neises, Gabrielle R.
AU  - Stanley, John R.
AU  - Katz, Stephen I.
T1  - A Unique Epithelial Basement Membrane Antigen Defined by a Monoclonal Antibody (KF-1).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/05//
VL  - 80
IS  - 5
M3  - Article
SP  - 392
EP  - 395
SN  - 0022202X
AB  - The basement membrane zone (BMZ) of human skin is a complex structure which contains several well-defined components including bullous pemphigoid antigen, laminin, type IV collagen, and proteoglycan. Characterization of additional basement membrane (BM) constituents has been limited by their relative inaccessibility, insolubility, and low tissue concentration. We have produced a murine monoclonal antibody that has enabled us to define a unique constituent of the BMZ of human stratified squamous epithelia. The monoclonal antibody (KF-1) was raised by standard techniques using suction blister-derived trypsinized human epidermal cells as the antigen. Indirect immunofluorescence and immunoperoxidase staining of human and rhesus monkey tissues with KF-1 produced linear BMZ staining of stratified squamous epithelia. Glandular and vascular BMs were not stained. Immunoelectron microscopic studies of normal human skin and esophagus showed specific binding of KF-1 to the lamina densa of the BMZ, a localization identical to that of type LV collagen. However, unlike type IV collagen, which is not species specific and is found in all BMs, the antigen defined by KF-1 is collagenase-resistant and is specific for primate stratified squamous epithelia. These findings confirm the existence of regional variation in BM composition, and demonstrate for the first time that the lamina densa of stratified squamous epithelial BMs contains a constituent other than type IV collagen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPITHELIUM
KW  - TISSUES
KW  - ANTIGENS
KW  - IMMUNITY
KW  - MONOCLONAL antibody probes
KW  - MONOCLONAL antibodies
N1  - Accession Number: 12553200; Breathnach, Stephen M. 1,2,3 Fox, Patricia A. 3 Neises, Gabrielle R. 3 Stanley, John R. 4 Katz, Stephen I. 3; Affiliation:  1: Visiting Associate, National Cancer Institute.  2: Dowling Fellow of British Association of Dermatologists.  3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  4: Dermatology Department, Uniformed Services University of Health Sciences, Bethesda, Maryland, U.S.A.; Source Info: May83, Vol. 80 Issue 5, p392; Subject Term: EPITHELIUM; Subject Term: TISSUES; Subject Term: ANTIGENS; Subject Term: IMMUNITY; Subject Term: MONOCLONAL antibody probes; Subject Term: MONOCLONAL antibodies; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12553200
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pato, Mary D.
AU  - Adelstein, Robert S.
AU  - Crouch, Deborah
AU  - Safer, Brian
AU  - Ingebretsen, Thomas S.
AU  - Cohen, Philip
T1  - The Protein Phosphatases Involved in Cellular Regulation.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/05/02/
VL  - 132
IS  - 2
M3  - Article
SP  - 283
EP  - 287
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Two homogeneous protein phosphatases, termed 'smooth muscle phosphatase-!' and `smooth muscle phosphatase-Il'. isolated from turkey gizzard as enzymes active against the 20-kDa light chain of smooth muscle myosin, and a third homogeneous protein phosphatase from rabbit reticulocytes. purified as an enzyme active against protein synthesis initiation factor eIF-2, were classified using the criteria defined by Ingebritsen and Cohen [Eur. J. Biochem. (1983) 132. 255- 261]. All three enzymes were type-2 protein phosphatases based on their specificity for the α-subunit of phosphorylase kinase and insensitivity to inhibitor-i and inhibitor-2. The substrate specificities of smooth muscle phosphatase-I and the eIF-2 phosphatase were similar to the catalytic subunit of protein phosphatase-2A. Smooth muscle phosphatase-I could be designated as protein phosphatase-2A1 and eIF-2 phosphatase as protein phosphatase-2A2 on the basis of their subunit compositions. The substrate specificity. dependence of activity on Mg2 + and subunit composition of smooth muscle phosphatase-II allowed its assignment as protein phosphatase-2C. [ABSTRACT FROM AUTHOR]
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KW  - SMOOTH muscle
KW  - PROTEINS
KW  - ERYTHROCYTES
KW  - PROTEIN synthesis
KW  - PHOSPHORYLATION
KW  - BLOOD cells
N1  - Accession Number: 15817166; Pato, Mary D. 1,2 Adelstein, Robert S. 1,2 Crouch, Deborah 1,2 Safer, Brian 1,2 Ingebretsen, Thomas S. 1,2 Cohen, Philip 1,2; Affiliation:  1: Laboratories of Molecular Cardiology and Molecular Hematology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda MD.  2: Department of Biochemistry. University of Dundee.; Source Info: 5/2/83, Vol. 132 Issue 2, p283; Subject Term: SMOOTH muscle; Subject Term: PROTEINS; Subject Term: ERYTHROCYTES; Subject Term: PROTEIN synthesis; Subject Term: PHOSPHORYLATION; Subject Term: BLOOD cells; Number of Pages: 5p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - DICK, STEVEN J.
AU  - MACCHI, BEATRICE
AU  - PAPAZOGLOU, SAVVAS
AU  - OLDFIELD, EDWARD H.
AU  - KORNBLITH, PAUL L.
AU  - SMITH, BARRY H.
AU  - GATELY, MAURICE K.
T1  - Lymphoid Cell-Glioma Cell Interaction Enhances Cell Coat Production by Human Gliomas: Novel Suppressor Mechanism.
JO  - Science
JF  - Science
Y1  - 1983/05/13/
VL  - 220
IS  - 4598
M3  - Article
SP  - 739
EP  - 742
SN  - 00368075
AB  - Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84713259; DICK, STEVEN J. 1; MACCHI, BEATRICE 1; PAPAZOGLOU, SAVVAS 1; OLDFIELD, EDWARD H. 1; KORNBLITH, PAUL L. 1; SMITH, BARRY H. 1; GATELY, MAURICE K. 1; Affiliations: 1: Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/13/1983, Vol. 220 Issue 4598, p739; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Mushinski, J. Frederic
AU  - Potter, Michael
AU  - Bauer, Steven R.
AU  - Reddy, E. Premkumar
T1  - DNA Rearrangement and Altered RNA Expression of the c-myb Oncogene in Mouse Plasmacytoid Lymphosarcomas.
JO  - Science
JF  - Science
Y1  - 1983/05/20/
VL  - 220
IS  - 4599
M3  - Article
SP  - 795
EP  - 798
SN  - 00368075
AB  - Three types of tumors termed plasmacytomas (ABPC's), lymphosarcomas (ABLS's), and plasmacytoid lymphosarcomas (ABPL's) arise in BALBIc mice treated with pristane and Abelson murine leukemia virus (A-MuLV). While most ABPC's and ABLS's contain integrated A-MuLVproviral genome and synthesize the v-abl RNA, most ABPL's do not. The ABPL tumors were examined for the expression of other oncogenes that may be associated with their transformed state, in the absence of transforming virus. These tumors expressed abundant c-myb RNA of unusually large size and showed DNA rearrangements of the c-myb locus. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84713269; Mushinski, J. Frederic 1; Potter, Michael 1; Bauer, Steven R. 2; Reddy, E. Premkumar 3; Affiliations: 1: Staff members, Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20205; 2: Graduate student, Department of Biochemistry, University of Maryland, College Park 20742; 3: Staff member, Laboratory of Cellular and Molecular Biology, Bethesda, Maryland 20205; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p795; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - GAINER, HAROLD
T1  - Vasopressin: An Experimental Model.
JO  - Science
JF  - Science
Y1  - 1983/05/20/
VL  - 220
IS  - 4599
M3  - Article
SP  - 856
EP  - 856
SN  - 00368075
N1  - Accession Number: 84713314; GAINER, HAROLD 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p856; Number of Pages: 8/9p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - GELMANN, EDWARD P.
AU  - POPOVIC, MIKULAS
AU  - BLAYNEY, DOUGLAS
AU  - MASUR, HENRY
AU  - SIDHU, GURDIP
AU  - STAHL, ROSALYN E.
AU  - GALLO, ROBERT C.
T1  - Proviral DNA of a Retrovirus, Human T-Cell Leukemia Virus, in Two Patients with AIDS.
JO  - Science
JF  - Science
Y1  - 1983/05/20/
VL  - 220
IS  - 4599
M3  - Article
SP  - 862
EP  - 865
SN  - 00368075
AB  - The acquired immune deficiency syndrome (AIDS) is characterized by Tlymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi's sarcoma. Human T-cell leukemia virus (HTLY-) is associated with Tcell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection in patients with AIDS, DNA from samples of peripheral blood lymphocytes from 33 AIDS patients was analyzed by Southern blot-hybridization with a radiolabeled cloned HTLV DNA probe. Analysis ofDNA from both the fresh (uncultured) lymphocytes and from T cells cultured with T-cell growth factor revealed the presence of integrated HTLV proviral sequences in lymphocytes from two of the patients, both of whom had antibody to HTLV. The proviral sequences could not be detected in blood samples obtained from these individuals at a later date, consistent with the possibility that the population of infected cells had become depleted. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84713319; GELMANN, EDWARD P. 1; POPOVIC, MIKULAS 1; BLAYNEY, DOUGLAS 2; MASUR, HENRY 3; SIDHU, GURDIP 4; STAHL, ROSALYN E. 5; GALLO, ROBERT C. 6; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Epidemiology Branch, National Cancer Institute; 3: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20205; 4: Department of Pathology, New York University Medical Center, New York 10010; 5: Department of Pathology, New York Veterans Administration Hospital, New York 10010; 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p862; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - GALLO, ROBERT C.
AU  - SARIN, PREM S.
AU  - GELMANN, E. P.
AU  - ROBERT-GUROFF, MARJORIE
AU  - RICHARDSON, ERSELL
AU  - KALYANARAMAN, V. S.
AU  - MANN, DEAN
AU  - SIDHU, GURDIP D.
AU  - STAHL, ROSALYN E.
AU  - ZOLLA-PAZNER, SUSAN
AU  - LEIBOWITCH, JACQUE
AU  - POPOVIC, MIKULAS
T1  - Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS).
JO  - Science
JF  - Science
Y1  - 1983/05/20/
VL  - 220
IS  - 4599
M3  - Article
SP  - 866
EP  - 868
SN  - 00368075
AB  - Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. The T-cell tropism of HTLV and its prevalence in the Caribbean basin prompted a search for it in patients with the epidemic T-cell immune deficiency disorder known as AIDS. Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. If the target cell of AIDS is the mature T cell as suspected, the methods used in these studies may prove useful for the long-term growth of these cells and for the identification of antigens specific for the etiological agent of AIDS. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84713320; GALLO, ROBERT C. 1; SARIN, PREM S. 1; GELMANN, E. P. 1; ROBERT-GUROFF, MARJORIE 1; RICHARDSON, ERSELL 1; KALYANARAMAN, V. S. 2; MANN, DEAN 3; SIDHU, GURDIP D. 4; STAHL, ROSALYN E. 4; ZOLLA-PAZNER, SUSAN 4; LEIBOWITCH, JACQUE 5; POPOVIC, MIKULAS 6; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland; 3: Laboratory of Human Carcinogenesis, National Cancer Institute; 4: Department of Pathology, New York Veterans Administration Hospital, New York 10010; 5: Department of Immunologie, Hôpital Raymond Poincaré, 92380 Garches, France; 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p866; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - EVA, ALESSANDRA
AU  - AARONSON, STUART A.
T1  - Frequent Activation of c-kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene.
JO  - Science
JF  - Science
Y1  - 1983/05/27/
VL  - 220
IS  - 4600
M3  - Article
SP  - 955
EP  - 956
SN  - 00368075
AB  - The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84713351; EVA, ALESSANDRA 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 5/27/1983, Vol. 220 Issue 4600, p955; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - VAN KAMMEN, DANIEL P.
AU  - MANN, LEE S.
AU  - STERNBERG, DAVID E.
AU  - SCHEININ, MIKA
AU  - NINAN, PHILIP T.
AU  - MARDER, STEPHEN R.
AU  - VAN KAMMEN, WELMOET B.
AU  - RIEDER, RONALD O.
AU  - LINNOILA, MARKKU
T1  - Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy.
JO  - Science
JF  - Science
Y1  - 1983/05/27/
VL  - 220
IS  - 4600
M3  - Article
SP  - 974
EP  - 977
SN  - 00368075
AB  - Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-β-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84713360; VAN KAMMEN, DANIEL P. 1; MANN, LEE S. 2; STERNBERG, DAVID E. 3; SCHEININ, MIKA 4; NINAN, PHILIP T. 5; MARDER, STEPHEN R. 6; VAN KAMMEN, WELMOET B. 7; RIEDER, RONALD O. 8; LINNOILA, MARKKU 4; Affiliations: 1: Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; 2: Laboratory of Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Yale University Medical School and Connecticut Mental Health Center, New Haven, Connecticut 06508; 4: Clinical Psychobiology Branch, National Institute of Mental Health; 5: Biological Psychiatry Branch, National Institute of Mental Health; 6: University of California and Brentwood Veterans Administration, Los Angeles 90093; 7: Western Psychiatric Institute and Clinic; 8: New York State Psychiatric Institute and Columbia University, New York 10032; Issue Info: 5/27/1983, Vol. 220 Issue 4600, p974; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - MUNSON, P. J.
AU  - RODBARD, D.
T1  - Number of Receptor Sites from Scatchard and Klotz Graphs: A Constructive Critique.
JO  - Science
JF  - Science
Y1  - 1983/05/27/
VL  - 220
IS  - 4600
M3  - Article
SP  - 979
EP  - 981
SN  - 00368075
N1  - Accession Number: 84713362; MUNSON, P. J. 1; RODBARD, D. 1; Affiliations: 1: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 5/27/1983, Vol. 220 Issue 4600, p979; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Moment, Gairdner
T1  - DIET, NUTRITION, AND CANCER.
JO  - BioScience
JF  - BioScience
Y1  - 1983/06//
VL  - 33
IS  - 6
M3  - Book Review
SP  - 398
EP  - 398
SN  - 00063568
AB  - The article reviews the book "Diet, Nutrition, and Cancer," by the Committee on Diet, Nutrition and Cancer.
KW  - Diet in disease
KW  - Cancer
KW  - Nonfiction
KW  - Diet, Nutrition & Cancer (Book)
N1  - Accession Number: 28051695; Moment, Gairdner 1; Affiliations: 1 : Guest Scientist, National Institute on Aging, Professor Emeritus, Biology, Coucher College, Baltimore, MD 21204;  Source Info: Jun1983, Vol. 33 Issue 6, p398; Subject Term: Diet in disease; Subject Term: Cancer; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 691
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DB  - 8gh
ER  - 

TY  - JOUR
AU  - Kilhoffer, Marie-Claude
AU  - Cook, G. Hope
AU  - Wolff, J.
T1  - Calcium-Independent Activation of Adenylate Cyclase by Calmodulin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/06//6/1/83
VL  - 133
IS  - 1
M3  - Article
SP  - 11
EP  - 15
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Adenylate cyclase of Bordetella pertussis is stimulated by calmodulin by two distinct interactions. At low activator concentrations (≈1 nM) the process is Ca2+-dependent (i.e. inhibited by EGTA added before calmodulin). High activator concentrations (≈ 0.1-10 µM) stimulate adenylate cyclase also in the presence of EGTA, an effect not accounted for by residual Ca2+ or low concentrations of Ca · calmodulin, which thus appears to be due to calcium-free calmodulin. Some calmodulin dose-response curves show both phases of stimulation, separated by a plateau of activity, and half-maximal activating concentrations differ by 100-300-fold. Both effects are on the V and not the Km for ATP and are not mimicked by 105-fold greater concentrations of parvalbumin or by various polyanions. In addition, adenylate cyclase stimulation at high calmodulin concentrations is greater in the presence of EGTA than in its absence. This enhancement is also produced by 1,10-phenathroline and 8-hydroxyquinoline but not by non-chelating isomers. These compounds are poor Ca2+ chelators, stimulate at any calmodulin concentration (unlike EGTA), and suggest regulation of this adenylate cyclase by a second metal ion. [ABSTRACT FROM AUTHOR]
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KW  - ADENYLATE cyclase
KW  - CALMODULIN
KW  - BORDETELLA pertussis
KW  - CALCIUM
KW  - METAL ions
KW  - ACTIVATION (Chemistry)
N1  - Accession Number: 13757570; Kilhoffer, Marie-Claude 1 Cook, G. Hope 1 Wolff, J. 1; Affiliation:  1: National Institute of Arthritis, Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Maryland; Source Info: 6/1/83, Vol. 133 Issue 1, p11; Subject Term: ADENYLATE cyclase; Subject Term: CALMODULIN; Subject Term: BORDETELLA pertussis; Subject Term: CALCIUM; Subject Term: METAL ions; Subject Term: ACTIVATION (Chemistry); Number of Pages: 5p; Document Type: Article
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ER  - 

TY  - RPRT
AU  - Hall, Russell P.
AU  - Peck, Gary L.
AU  - Lawley, Thomas J.
T1  - Circulating IgA Complexes in Patients with Psoriasis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/06//
VL  - 80
IS  - 6
M3  - Report
SP  - 465
EP  - 467
SN  - 0022202X
AB  - The sera of 21 patients with psoriasis were examined for the presence of IgA-containing circulating immune complexes (CIC) using the Raji IgA radioimmunoassay. In addition, the Raji IgG radioimmunoassay and 125I-Clq binding assay were used to detect IgG- and IgM-containing CIC. Twenty five patients with other hyperkeratotic skin disorders were studied as controls. Patients were studied before institution of systemic therapy with etretinate (20 patients) or 13-<em>cis</em>-retinoic acid (1 patient). In addition, sera of 15 of the patients treated with etretinate were studied before, during, and after therapy. The extent of pretreatment disease involvement as well as response to therapy were evaluated in a blinded fashion. Fourteen of 21 (67%) patients with psoriasis had evidence of IgA-containing CIC at some time during the course of their disease, as compared to only 1 of 25 patients with other hyperkeratotic skin disorders. In contrast, only 2 of 19 (11%) had evidence of IgG-containing CIC using the Raji IgG assay, and only 1 of 19 (5%) had evidence of IgG- or IgM-containing CIC using the 125I-Clq binding assay positive correlation was found between the extent of pretreatment disease involvement and the level of IgA-containing CIC by linear regression analysis (<em>p</em> = 0.01). There was, however, no correlation between clinical improvement and the presence or level of IgA-containing CIC in 15 patients followed during therapy. Sucrose density gradient analysis of the IgA-containing CIC found in 2 of these patient demonstrated IgA-containing CIC in the 9S to 13S region. The finding of IgA-containing CIC in a significant number of patients with psoriasis and the relative absence of IgG- or IgM-containing CIC suggest that IgA containing CIC may play a role in psoriasis. The lack of correlation with clinical improvement, however, suggests these IgA-containing CIC are not directly related to the cutaneous manifestations of psoriasis, but may be important in the modulation of immune or inflammatory responses in these patients. [ABSTRACT FROM AUTHOR]
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KW  - PSORIASIS
KW  - SKIN diseases
KW  - RADIOIMMUNOASSAY
KW  - ETRETINATE
KW  - THERAPEUTICS
KW  - REGRESSION analysis
N1  - Accession Number: 12534883; Hall, Russell P. 1 Peck, Gary L. 1 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A..; Source Info: Jun83, Vol. 80 Issue 6, p465; Subject Term: PSORIASIS; Subject Term: SKIN diseases; Subject Term: RADIOIMMUNOASSAY; Subject Term: ETRETINATE; Subject Term: THERAPEUTICS; Subject Term: REGRESSION analysis; Number of Pages: 3p; Document Type: Report
L3  - 10.1111/1523-1747.ep12534883
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DB  - aph
ER  - 

TY  - JOUR
AU  - Yancey, Kim B.
AU  - Cason, Joseph C.
AU  - Hall, Russell P.
AU  - Lawley, Thomas J.
T1  - Dietary Gluten Challenge Does Not Influence the Levels of Circulating Immune Complexes in Patients with Dermatitis Herpetiformis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/06//
VL  - 80
IS  - 6
M3  - Article
SP  - 468
EP  - 471
SN  - 0022202X
AB  - To examine the relationship between the gluten-sensitive enteropathy (GSE) and IgA circulating immune complexes (CIC) in dermatitis herpetiformis (DH) a series of dietary gluten-challenge studies were performed in patients with DH and patients with ordinary GSE. Serial serum samples were monitored for IgA-, IgG-, and IgM-containing CIC levels. In the first study, 9 DH patients and 5 controls were fed 20 g of gluten flour as a breakfast meal on 1 of 2 consecutive study days. DH patients did not develop or increase their levels of CIC after gluten-challenge or gluten-free meals. There was no significant difference between the DH patients and the control group in regard to development of CIC. To evaluate the effect of dietary gluten in another form, 8 DH patients were given meals containing 100 g of boiled Canadian cracked wheat. Two patients with ordinary GSE were also challenged with cracked wheat, Again there was no elevation or induction of CIC above baseline determinations by gluten-challenge meals, These studies suggest that dietary gluten does not induce the formation of CIC in patients with DH. [ABSTRACT FROM AUTHOR]
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KW  - DERMATITIS herpetiformis
KW  - GLUTEN
KW  - INTESTINAL diseases
KW  - DIET
KW  - SERUM
KW  - MEAL
N1  - Accession Number: 12534895; Yancey, Kim B. 1 Cason, Joseph C. 1 Hall, Russell P. 1 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jun83, Vol. 80 Issue 6, p468; Subject Term: DERMATITIS herpetiformis; Subject Term: GLUTEN; Subject Term: INTESTINAL diseases; Subject Term: DIET; Subject Term: SERUM; Subject Term: MEAL; NAICS/Industry Codes: 311212 Rice Milling; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12534895
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sauder, Daniel N.
AU  - Noonan, Frances P.
AU  - DeFabo, Edward C.
AU  - Katz, Stephen I.
T1  - Ultraviolet Radiation Inhibits Alloantigen Presentation by Epidermal Cells: Partial Reversal by the Soluble Epidermal Cell Product, Epidermal  Cell-Derived Thymocyte-Activating Factor (ETAF).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/06//
VL  - 80
IS  - 6
M3  - Article
SP  - 485
EP  - 489
SN  - 0022202X
AB  - It has been postulated that ultraviolet radiation (UVR) alters antigens presentation by macrophages. This is thought to be due, in part, to inhibition of macrophage-derived interleukin 1 (IL-1), which is a hormone-like factor with immunoregulatory functions. Conventional stimulator cells for antigen presentation are macrophages; however, other cell types such as epidermal Langerhans cells are capable of antigen presentation. Keratinocytes also play a role in the immune system by providing a factor with IL-1-like activity, termed <em>E</em> dermal cell-derived <em>T</em>hymocyte-<em>A</em>ctivating <em>F</em>actor (ETAF).The purpose of this study was to determine whether UVR affects alloantigen presentation by epidermal cells and if so, whether the UV-induced change is due to UVR alteration in ETAF activity. Epidermal cells from UV-treated BALB/c mice (UV-EC) or from non-UV-treated mice (EC) were x-irradiated and then cocultured for 5 days with allogeneic T-cells from C57B1/6 mice. UV EC caused less T-cell stimulation than did EC from non-UV-treated animals. When chromatography purified fractions of ETAF were added to cultured UV-EC, partial restoration of T-cell stimulation was seen. These results suggest that this UV-induced defect in alloantigen presentation is due, in part, to decreased ETAF activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - MACROPHAGES
KW  - ULTRAVIOLET radiation
KW  - INTERLEUKIN-1
KW  - LANGERHANS cells
KW  - T cells
N1  - Accession Number: 12534951; Sauder, Daniel N. 1 Noonan, Frances P. 2 DeFabo, Edward C. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology branch, National Cancer Institute, National institute of Health, Bethesda, Maryland, U.S.A..  2: N.C.I. Frederick Cancer Research Facility, Frederick, Maryland, U.S.A..; Source Info: Jun83, Vol. 80 Issue 6, p485; Subject Term: ANTIGENS; Subject Term: MACROPHAGES; Subject Term: ULTRAVIOLET radiation; Subject Term: INTERLEUKIN-1; Subject Term: LANGERHANS cells; Subject Term: T cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12534951
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gail, Mitchell H.
T1  - Comment.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1983/06//
VL  - 78
IS  - 382
M3  - Article
SP  - 275
SN  - 01621459
AB  - The article comments on the paper by Murray Aitkin, Nan Laird and Brian Francis which presents an analyses of survival of patients in the Stanford Heart Transplantation Program, published in the June 1983 issue of the "Journal of the American Statistical Association." The author wishes to congratulate Aitkin, Laird and Francis and to elaborate on some of their cautionary remarks, such as "the apparent benefit of transplant is dwarfed by the magnitude of our uncertainty." The author shall discuss the weakness of the evidence, and he shall use the authors' models to highlight this weakness. An ideal experiment to determine whether transplantation is beneficial would be to regard a patient as eligible for study at the time a suitably matched heart became available and then to randomly allocate that patient either to transplantation or to conservative management. A valid comparison of postrandomization survival could be made, even without covariate adjustment. However, regression methods or stratified analyses could be used to adjust for treatment imbalances on known covariates, such as waiting time since entry into the program. Unfortunately, the present data are not protected by randomization. A surgeon might choose to give the heart to that one of a pair of potential recipients who had waited longer. But waiting time is a dominant covariate: the longer you wait, the better is your prognosis on conservative management.
KW  - REGRESSION analysis
KW  - ANALYSIS of covariance
KW  - MATHEMATICAL models
KW  - HOSPITAL costs
KW  - HEART transplantation
KW  - MEDICAL care costs
KW  - UNCERTAINTY
KW  - CARDIAC surgery -- Patients
KW  - FRANCIS, Brian
KW  - JOURNAL of the American Statistical Association (Periodical)
N1  - Accession Number: 4607615; Gail, Mitchell H. 1; Affiliations: 1: Medical Statistical Investigator, Biometry Branch, National Cancer Institute, Bethesda, MD 20205.; Issue Info: Jun83, Vol. 78 Issue 382, p275; Thesaurus Term: REGRESSION analysis; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: HOSPITAL costs; Subject Term: HEART transplantation; Subject Term: MEDICAL care costs; Subject Term: UNCERTAINTY; Subject Term: CARDIAC surgery -- Patients; Reviews & Products: JOURNAL of the American Statistical Association (Periodical); People: FRANCIS, Brian; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Wei, L. J.
AU  - Gail, M. H.
T1  - Nonparametric Estimation for a Scale-Change With Censored Observations.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1983/06//
VL  - 78
IS  - 382
M3  - Article
SP  - 382
SN  - 01621459
AB  - Nonparametric point and interval estimators of the ratio of two scale parameters are given for arbitrarily right-censored data based on the idea of Hodges and Lehmann (1963). These estimators are defined in terms of rank test statistics for testing the equality of two survival distributions. The asymptotic properties and efficiencies of estimators corresponding to the tests studied by Gill (1980) are investigated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESTIMATION theory
KW  - NONPARAMETRIC statistics
KW  - MATHEMATICAL statistics
KW  - STATISTICAL hypothesis testing
KW  - STOCHASTIC processes
KW  - DISTRIBUTION (Probability theory)
KW  - PROBABILITY theory
KW  - INTERVAL analysis (Mathematics)
KW  - LEAST squares
KW  - ASYMPTOTIC theory
KW  - Accelerated failure time model
KW  - Arbitrarily right-censored observations
KW  - Asymptotic relative efficiency
KW  - Gehan-Gilbert test
KW  - Logrank test.
N1  - Accession Number: 4607779; Wei, L. J. 1; Gail, M. H. 2; Affiliations: 1: Professor, Department of Statistics, George Washington University, Washington, D.C. 20052.; 2: Medical Statistical Investigator, Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, Bethesda, MD 20205.; Issue Info: Jun83, Vol. 78 Issue 382, p382; Thesaurus Term: ESTIMATION theory; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: STOCHASTIC processes; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: PROBABILITY theory; Subject Term: INTERVAL analysis (Mathematics); Subject Term: LEAST squares; Subject Term: ASYMPTOTIC theory; Author-Supplied Keyword: Accelerated failure time model; Author-Supplied Keyword: Arbitrarily right-censored observations; Author-Supplied Keyword: Asymptotic relative efficiency; Author-Supplied Keyword: Gehan-Gilbert test; Author-Supplied Keyword: Logrank test.; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Hoar, Sheila
T1  - Job Exposure Matrix Methodology.
JO  - Journal of Toxicology -- Clinical Toxicology
JF  - Journal of Toxicology -- Clinical Toxicology
Y1  - 1983/06//
VL  - 21
IS  - 1/2
M3  - Article
SP  - 9
EP  - 26
SN  - 07313810
N1  - Accession Number: 79032216; Hoar, Sheila 1; Affiliations: 1: Environmental Epidemiology Branch Division of Cancer, Cause and Prevention National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 1983, Vol. 21 Issue 1/2, p9; Number of Pages: 18p; Document Type: Article
L3  - 10.3109/15563658308990408
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Zlegler, Regina G.
T1  - Assessing Diet in Case-Control Studies of Cancer.
JO  - Journal of Toxicology -- Clinical Toxicology
JF  - Journal of Toxicology -- Clinical Toxicology
Y1  - 1983/06//
VL  - 21
IS  - 1/2
M3  - Article
SP  - 129
EP  - 150
SN  - 07313810
N1  - Accession Number: 79032215; Zlegler, Regina G. 1; Affiliations: 1: Environmental Epidemiology Branch Division of Cancer, Cause and Prevention National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 1983, Vol. 21 Issue 1/2, p129; Number of Pages: 22p; Document Type: Article
L3  - 10.3109/15563658308990413
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06526-027
AN  - 2006-06526-027
AU  - Zahn-Waxler, Carolyn
T1  - Changing Views of Childhood.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1983/06//
VL  - 28
IS  - 6
SP  - 455
EP  - 456
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06526-027. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn-Waxler, Carolyn; Laboratory of Developmental Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Language; Motor Development; Psychosocial Development; Social Skills. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Moore, Shirley G. (Ed); Cooper, Catherine R. (Ed). The Young Child: Reviews of Research, Vol. 3=Washington, D.C.: National Association for the Education of Young Children, 1982. 723 pp. $7.15; 1982. References Available: Y. Page Count: 2. Issue Publication Date: Jun, 1983. 
AB  - Reviews the book, The Young Child: Reviews of Research, Vol. 3 edited by Shirley G. Moore and Catherine R. Cooper (1982). This book provides a comprehensive summary and integration of research in several areas of young children's socialemotional, cognitive, and physical development Children's social-emotional beginnings--including factors related to thriving, biological aspects of early parent-child interaction, and child rearing during the preschool years--constitute the first topics. Language and thought are cogently discussed in the context of social perspective-taking and egocentrism, concept development, and how adults talk to young children Social development is considered in terms of peer relationships and social skills, the facilitation of altruism, and deleterious effects of labeling 'minority' children. Biological malleability is addressed in relation to sex differences and motor development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - young children
KW  - social development
KW  - child interaction
KW  - social skills
KW  - concept development
KW  - motor development
KW  - 1983
KW  - Childhood Development
KW  - Language
KW  - Motor Development
KW  - Psychosocial Development
KW  - Social Skills
KW  - 1983
U2  - Moore, Shirley G. (Ed); Cooper, Catherine R. (Ed). (1982); The Young Child: Reviews of Research, Vol. 3; Washington, D.C.: National Association for the Education of Young Children, 1982. 723 pp. $7.15
DO  - 10.1037/022101
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - REDDY, E. PREMKUMAR
T1  - Nucleotide Sequence Analysis of the T24 Human Bladder Carcinoma Ontogene.
JO  - Science
JF  - Science
Y1  - 1983/06/03/
VL  - 220
IS  - 4601
M3  - Article
SP  - 1061
EP  - 1063
SN  - 00368075
AB  - The nucleotide sequence of the 124 human bladder carcinoma oncogene was determined, and the coding and noncoding sequences of the genome were identified. The amino acid sequence of p21, the translational product of the 724 oncogene, was predicted from the nucleotide sequence of the oncogene. Comparison of this sequence with that of the normai cellular homolog showed that a single point mutation in the coding sequences of the 124 oncogene resulted in the acquisition of transforming properties. Other differences betveen the 724 oncogene hnd its normal cellular homolog were found in the 5' noncoding and 3' noncoding sequences, but these differences appear to be due to polymorphism and do not play a significant role in the transformation process. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84713400; REDDY, E. PREMKUMAR 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 6/ 3/1983, Vol. 220 Issue 4601, p1061; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DOCAMPO, ROBERTO
AU  - MORENO, SILVIA N. J.
AU  - MUNIZ, RAMIRO P. A.
AU  - CRUZ, FERNANDO S.
AU  - MASON, RONALD P.
T1  - Light-Enhanced Free Radical Formation and Trypanocidal Action of Gentian Violet (Crystal Violet).
JO  - Science
JF  - Science
Y1  - 1983/06/17/
VL  - 220
IS  - 4603
M3  - Article
SP  - 1292
EP  - 1295
SN  - 00368075
AB  - Transmission of Chagas' disease by transfusion of blood containing Trypanosoma cruzi has often been reported, and gentian violet, a triarylmethane dye, is widely used by blood banks in attempts to eliminate such transmission. In a study of intact trypanosomes, gentian violet was found to undergo a one-electron reduction to produce a carbon-centered free radical as demonstrated by electron spin resonance spectroscopy. Either reduced nicotinamide adenine dinucleotide or the reduced dinucleotide phosphate could serve as a source of reducing equivalents for the production of this free radical by homogenates of Trypanosoma cruzi. The formation of this free radical, and the trypanocidal action of gentian violet, were enhanced by light. The enhanced free radical formation may be the basic cause of the selective toxicity of gentian violet to Trypanosoma cruzi. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88000766; DOCAMPO, ROBERTO 1; MORENO, SILVIA N. J. 1; MUNIZ, RAMIRO P. A. 2; CRUZ, FERNANDO S. 2; MASON, RONALD P. 3; Affiliations: 1: Centro de Investigaciones Bioenergéticas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; 2: Centro Brasileiro de Pesquisas Fisicas and Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 3: Laboratory of Environmental Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 6/17/1983, Vol. 220 Issue 4603, p1292; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - VINCENT, STEVEN R.
AU  - HÖKFELT, THOMAS
AU  - SKIRBOLL, LANA R.
AU  - JANG-YEN WU
T1  - Hypothalamic γ-Aminobutyric Acid Neurons Project to the Neocortex.
JO  - Science
JF  - Science
Y1  - 1983/06/17/
VL  - 220
IS  - 4603
M3  - Article
SP  - 1309
EP  - 1311
SN  - 00368075
AB  - Three groups of γ-aminobutyric acid-containing neurons were found in the mammillary region of the posterior hypothalamus. The groups correspond to the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Many cells in these nuclei were retrogradely labeled with fast blue after the injection of this fluorescent dye into the neocortex. Immunohistochemical experiments showed that these same neurons also contained the γ-aminobutyric acid-synthesizing enzyme glutamate decarboxylase. These results provide morphological evidence for a γ-aminobutyric acid pathway arising in magnocellular neurons of the posterior hypothalamus and innervating the neocortex. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 88000773; VINCENT, STEVEN R. 1; HÖKFELT, THOMAS 1; SKIRBOLL, LANA R. 2; JANG-YEN WU 3; Affiliations: 1: Department of Histology, Karolinska Institute, S-104 01, Stockholm, Sweden; 2: Biological Phychiatry Brach, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030; Issue Info: 6/17/1983, Vol. 220 Issue 4603, p1309; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hitchcock, Penny J.
T1  - Aberrant Migration of Lipopolysaccharide in Sodium Dodecyl Sulfate/Polyacrylamide Gel Electrophoresis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/07//7/1/83
VL  - 133
IS  - 3
M3  - Article
SP  - 685
EP  - 688
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Purified lipopolysaccharides of salmonellae strains were separated by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Pre-electrophoresis of polyacrylamide gels had no apparent effect on one-dimensional silver-stained lipopolysaccharide profiles. However, without pre-electrophoresis, two-dimensional and three-dimensional patterns contained numerous bands with varied migration patterns compared to those in the one-dimension gels. The lipopolysaccharide was altered within the polyacrylamide gel during electrophoresis. Pre-electrophoresis of gels eliminated a berrant migration patterns. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SALMONELLA typhimurium
KW  - ENDOTOXINS
KW  - POLYACRYLAMIDE gel electrophoresis
KW  - PHENOLS
KW  - ENZYMES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13747377; Hitchcock, Penny J. 1; Affiliation:  1: Department of Health and Human Services, National Institute of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana; Source Info: 7/1/83, Vol. 133 Issue 3, p685; Subject Term: SALMONELLA typhimurium; Subject Term: ENDOTOXINS; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: PHENOLS; Subject Term: ENZYMES; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Paia, S. Balakrishna
AU  - Krishnabhargava, M.
AU  - Vasantharajan, V.N.
T1  - Evaluation of carcinogenicity of fenaminosulf ( P ‐dimethylaminobenzenediazosodium sulfonate) and dimethyl‐P‐phenylenediamine in rats.
JO  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF  - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1  - 1983/07//
VL  - 18
IS  - 4
M3  - Article
SP  - 503
EP  - 517
SN  - 03601226
AB  - Carcinogenicity of the fungicide fenaminosulf (p‐dimethylami‐nobenzenediazosodium sulfonate) and one of its bacterial metabolite, dimethyl‐p‐phenylenediamine (DMPDA) was evaluated in rats. Over a 17 month period, rats fed with 250 mg of the compounds per kg of feed (in the presence or absence of nitrite) did not develop tumors. Phenols were detected in the urine and faeces of rats receiving either fenaminosulf or DMPDA suggesting possible detoxification of these compounds. These compounds being positive in mutagenicity screening tests in the bacteria, in the light of our present studies it is suggested that testing potential carcinogens in experimental animals is a pre‐requisite before arriving at definitive conclusions on the carcinogenicity of chemicals. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75490545; Paia, S. Balakrishna 1,2 Krishnabhargava, M. 3 Vasantharajan, V.N. 1; Affiliation:  1: Microbiology and Cell Biology Laboratory, Indian Institute of Science, Bangalore, 560012, India  2: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, N.C., 27709, U.S.A.  3: Kidwai Memorial Cancer Institute, Bangalore, India; Source Info: Jul1983, Vol. 18 Issue 4, p503; Number of Pages: 15p; Document Type: Article
L3  - 10.1080/10934528309375119
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DP  - EBSCOhost
DB  - aph
ER  - 
TY  - JOUR
ID  - 2006-06525-036
AN  - 2006-06525-036
AU  - Vietze, Peter M.
T1  - Preventing Infant Psychopathology.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1983/07//
VL  - 28
IS  - 7
SP  - 549
EP  - 550
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06525-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Vietze, Peter M.; Mental Retardation Research Centers Program, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Developmental Stages; Infant Development; Mental Health Programs; Program Development; Psychopathology. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Greenspan, Stanley I. Psychopathology and Adaptation in Infancy and Early Childhood: Principles of Clinical Diagnosis and Preventive Intervention=New York: International Universities Press, 1981. 278 pp. $27.50; 1981. References Available: Y. Page Count: 2. Issue Publication Date: Jul, 1983. 
AB  - Reviews the book, Psychopathology and Adaptation in Infancy and Early Childhood: Principles of Clinical Diagnosis and Preventive Intervention by Stanley I. Greenspan (1981). The present work fleshes out the brief overview provided in the earlier volume and provides case material to illustrate the six stages of development through which the infant passes. In the description of most stages, four factors are considered: child capacities, environmental characteristics, fears of the caretaker, and principles of prevention intervention and treatment. These are followed by case materials to illustrate various aspects of the stage with examples from the Clinical Infant Development Program of the Mental Health Study Center. This work represents a noteworthy integration of clinical practice, theoretical formulation, and systematic observation of infants and mothers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - prevention intervention
KW  - infant passes
KW  - infant psychopathology
KW  - infant development
KW  - clinical diagnosis
KW  - developmental stages
KW  - 1983
KW  - Developmental Stages
KW  - Infant Development
KW  - Mental Health Programs
KW  - Program Development
KW  - Psychopathology
KW  - 1983
U2  - Greenspan, Stanley I. (1981); Psychopathology and Adaptation in Infancy and Early Childhood: Principles of Clinical Diagnosis and Preventive Intervention; New York: International Universities Press, 1981. 278 pp. $27.50
DO  - 10.1037/022176
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - AQUADRO, CHARLES F.
T1  - Macromolecular Sequences in Systematics and Evolutionary Biology.
JO  - Science
JF  - Science
Y1  - 1983/07/08/
VL  - 221
IS  - 4606
M3  - Article
SP  - 147
EP  - 148
SN  - 00368075
N1  - Accession Number: 84672880; AQUADRO, CHARLES F. 1; Affiliations: 1: Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 7/ 8/1983, Vol. 221 Issue 4606, p147; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ikeda, Toshihiko
AU  - Altieri, Mario
AU  - Yuan-Tsong Chen
AU  - Nakamura, Michitoshi
AU  - Tukey, Robert H.
AU  - Nebert, Daniel W.
AU  - Negishi, Masahiko
T1  - Characterization of Cytochrome P2-450 (20-S) mRNA.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/07/15/
VL  - 134
IS  - 1
M3  - Article
SP  - 13
EP  - 18
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Mouse liver cytochrome P2-450 is defined as the major isosafrole-inducible form of P-450 which is most specific for isosafrole metabolism. λ.AhP-1 represents a 15.5 × 103-base-pair segment of mouse genomic DNA having the cytochrome P1-450 gene (&approx;4600 base pairs) located in the middle portion. Using various subclones as probes, we investigated the differential expression of P1-450 mRNA and P2-450 mRNA induction as a function of association with the Ah locus, 3-methylcholamhrene or isosafrole dosage, tissue specificity, and developmental age. Both P1-450 (23-S) mRNA and P2-450 (20-S) mRNA induction processes are regulated by the Ah receptor• P2-450 mRNA is about 10-fold more sensitive than P1-450 mRNA to induction by either 3-methylcholantbrene or isosafrole. Phenobarbital pretreatment has no effect at all on either P1-450 mRNA or P2-450 mRNA. Whereas both P1-450 mRNA and P2-450 mRNA are induced by 3-methylcholanthrcne in C57BL/6N liver, P1-450 (23-S) mRNA but not P2-450 (20-S) mRNA is induced by 3-methylcholanthrene in C57BL/6N kidney. P1-450 mRNA induction by 3-methyleholanthrene is measurable in C57BL/6N liver at day 15 of gestation, and the expression becomes enhanced with increasing age. P1-450 mRNA induction by 3-metbyleholanthrcne in C57BL/6N liver appears about 7 days later during development than 3-methylcholanthrene-inducible P1-450 mRNA. Both 3-methylcholanthrene-induced P1 450 mRNA and P2-450 mRNA are detectable in DBA/2N liver; their appearance is later in development, however, and at. lower concentrations than that seen with C57BL/6N liver. P1-450 (23-S) mRNA and P2-450 (20-S) mRNA appear to hybridize to a common 5′ fragment of the P1-450 gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOCHROME P-450
KW  - PROTEIN metabolism
KW  - MESSENGER RNA
KW  - CELL receptors
KW  - MOLECULAR genetics
KW  - BIOCHEMISTRY
N1  - Accession Number: 13832442; Ikeda, Toshihiko 1 Altieri, Mario 1 Yuan-Tsong Chen 1 Nakamura, Michitoshi 1 Tukey, Robert H. 1 Nebert, Daniel W. 1 Negishi, Masahiko 1; Affiliation:  1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 7/15/83, Vol. 134 Issue 1, p13; Subject Term: CYTOCHROME P-450; Subject Term: PROTEIN metabolism; Subject Term: MESSENGER RNA; Subject Term: CELL receptors; Subject Term: MOLECULAR genetics; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nakamura, Michitoshi
AU  - Negishi, Masahiko
AU  - Altieri, Mario
AU  - Yuan-Tsong Chen
AU  - Ikeda, Toshihiko
AU  - Tukey, Robert H.
AU  - Nebert, Daniel W.
T1  - Structure of the Mouse Cytochrome P1-450 Genomic Gene.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/07/15/
VL  - 134
IS  - 1
M3  - Article
SP  - 19
EP  - 25
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Clone 46 was previously shown to represent mouse cytochrome P1-450 cDNA by both translation arrest experiments and segregation of induced P1-450 mRNA with induced aryl hydrocarbon hydroxylase activity among individual 3-methylcholanthrene-treated offspring of the (C57BL/6N)(DBA/2N)F1 × DBA/2N backcross. With clone 46 as a probe, a MOPC 41 mouse genomic-DNA library was screened. λ3NT 12, a 16 × 103-base-pair insert of genomic DNA grown in a recombinant Charon 4A λ vector phage, was isolated and characterized. It was determined that clone 46 hybridizes to the extreme 5′ end of λ3NT12. pMJE12, a 3.0 × 103-base-pair fragment in the 5′ region of λ3NT12, was subcloned in plasmid pBR322 and used as a probe to screen again the same mouse-DNA library; recombinant phages λ3NT13, λ3NT14, and λAhP-1 were isolated and characterized. The relative orientation of each of the four genomic clones on the mouse chromosome was determined. Only λAhP-1 contains the entire P1-450 genomic gene, which by R-loop analysis spans about 46 × 102 base pairs and contains at least five exons. Clone 46 is shown to be a 3′ unique sequence of the genomic P1-450 gene. The λAhP-1 genomic-DNA clone from the MOPC 41 plasmocytoma is shown by a series of restriction enzymes to be the same as genomic DNA from normal mouse liver. With a subclone in the 5′ portion of the P1-450 gene, two and three hybridizable fragments are found with mouse genomie DNA that has been digested with EcoRI and BamHI, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOCHROME P-450
KW  - MOLECULAR cloning
KW  - CHROMOSOMES
KW  - GENES
KW  - ENZYMES
KW  - CELL receptors
KW  - MESSENGER RNA
KW  - RECOMBINANT DNA
KW  - BIOCHEMISTRY
N1  - Accession Number: 13832525; Nakamura, Michitoshi 1 Negishi, Masahiko 1 Altieri, Mario 1 Yuan-Tsong Chen 1 Ikeda, Toshihiko 1 Tukey, Robert H. 1 Nebert, Daniel W. 1; Affiliation:  1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 7/15/83, Vol. 134 Issue 1, p19; Subject Term: CYTOCHROME P-450; Subject Term: MOLECULAR cloning; Subject Term: CHROMOSOMES; Subject Term: GENES; Subject Term: ENZYMES; Subject Term: CELL receptors; Subject Term: MESSENGER RNA; Subject Term: RECOMBINANT DNA; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Holbrook, Karen A.
AU  - Hennings, Henry
T1  - Phenotypic Expression of Epidermal Cells in Vitro: A Review.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/07/15/Jul83 Supplement
VL  - 81
M3  - Article
SP  - 11s
EP  - 24s
SN  - 0022202X
AB  - Disaggregated epidermal cells, sheets of epidermis, and explants of partial and full-thickness skin have been grown in cell, organ, and explant cultures. Each type of epidermal sample has also been "cultured" as a graft on a living animal host. The extent of tissue-specific phenotypic expression by the epidermal cell varies with the type of culture and the culture conditions: medium, biologic and pharmacologic additives, substrate, cell density, ph, and temperature. Specific culture conditions can be chosen to select for certain phenotypic traits, in spite of the diversity of conditions that may be used for culture, keratinocytes in cell, explant, and organ cultures undergo a similar pattern of differentiation. They stratify and keratinize, but rarely express a complete program of keratinization. Many of the characteristics associated with this pattern of differentiation are also observed in fetal epidermis during development. In culture, normal tissue architecture is usually absent; cells organize in flattened, loosely associated layers, synthesize a different pattern of keratin polypeptides, form keratohyalin granules only sporadically, and rarely contain lamellar granules. Epidermal differentiation in explant and organ cultures can be evaluated in regions of the explant, epibolic zone, and outgrowth apron. The epidermis of the original explant undergoes hyperproliferation, degeneration, sloughing, and then regeneration of a thin tissue. The cells in the epithelial outgrowth zone stratify and differentiate almost identically with those in cell culture. Neogenesis of structures in the basement-membrane zone can be followed in all three regions of the explant culture, Sheets of epidermis or epidermal cells transplanted onto or into a host animal show the most complete expression of the epidermal phenotype. After a period of hyperplastic growth, the cell layers become established in a pattern nearly identical to that in vivo. A complete granular layer is formed and stratum corneum cells, which are structurally and biochemically equivalent to those in tissue, differentiate. In some instances, the epidermis reconstructed from cells or tissue is indistinguishable from adjacent host epidermis. Experiments that include serial transfer from one culture system to another demonstrate the plasticity of the epidermal cell and its ability to respond variously to its environment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - EPIDERMIS
KW  - CELLS
KW  - KERATINOCYTES
KW  - TISSUES
KW  - KERATIN
N1  - Accession Number: 12540003; Holbrook, Karen A. 1 Hennings, Henry 2; Affiliation:  1: Departments of Biological Structure and Medicine (Dermatology), University of Washington School of Medicine, Seattle, Washington  2: Laboratory of Cellular Carcinogenesis, and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jul83 Supplement, Vol. 81, p11s; Subject Term: SKIN; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: KERATINOCYTES; Subject Term: TISSUES; Subject Term: KERATIN; Number of Pages: 14p; Document Type: Article
L3  - 10.1111/1523-1747.ep12540003
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hennings, Henry
AU  - Holbrook, Karen A.
AU  - Yuspa, Stuart H.
T1  - Potassium Mediation of Calcium-Induced Terminal Differentiation of Epidermal Cells in Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/07/15/Jul83 Supplement
VL  - 81
M3  - Article
SP  - 50s
EP  - 55s
SN  - 0022202X
AB  - Epidermal cells cultured in low-calcium medium (0.02- 0.1 m<em>M</em>) grow as a monolayer, in contrast to the stratified pattern of growth in medium with standard calcium levels (1.2-1.8 m<em>M</em>). These low-calcium cells lack desmosomes and maintain a high proliferation rate. Raising the extracellular calcium to >0.1 m<em>M</em> induces rapid desmosome formation followed by stratification, inhibition of proliferation, formation of cornified envelopes, and sloughing of the cells from the culture dish. This calcium-induced terminal differentiation program is characterized by an increase in the intracellular levels of sodium and potassium at 12 to 24 hours and is not blocked by inhibitors of calcium or sodium flux. Of 40 to 50 agents tested as inhibitors of calcium-induced epidermal differentiation, only ouabain, harmaline, A23187, and 8(diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) were effective. These agents did not block the earliest calcium-induced effect (desmosome formation), but they did inhibit later stages in the program of terminal differentiation. Their detailed mechanism of action is unclear, although ouabain inhibits the sodium pump (Na+K+ATPase), lowering potassium and elevating sodium in the cells. The other inhibitors also prevented the calcium-induced elevation of intracellular potassium with no common effect on intracellular sodium. Reduction of potassium in the medium from the usual level of 6.5 m<em>M</em> to 0.1 m<em>M</em> lowers intracellular potassium by 60 to 70 percent and prevents calcium-induced differentiation, This result, along with the inhibitor studies, suggests that potassium plays an important role in epidermal terminal differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - POTASSIUM
KW  - CALCIUM
KW  - CELLS
KW  - SODIUM
KW  - SKIN
N1  - Accession Number: 12540491; Hennings, Henry 1 Holbrook, Karen A. 2 Yuspa, Stuart H. 1; Affiliation:  1: In Vitro Pathogenesis Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland.  2: Department of Biological Structural and Medicine (Dermatology,), University of Washington, Seattle, Washington, U S A.; Source Info: Jul83 Supplement, Vol. 81, p50s; Subject Term: EPIDERMIS; Subject Term: POTASSIUM; Subject Term: CALCIUM; Subject Term: CELLS; Subject Term: SODIUM; Subject Term: SKIN; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12540491
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Steinert, Peter M.
AU  - Steven, Alasdair C.
AU  - Roop, Dennis R.
T1  - Structural Features of Epidermal Keratin Filaments Reassembled in Vitro.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/07/15/Jul83 Supplement
VL  - 81
M3  - Article
SP  - 86s
EP  - 90s
SN  - 0022202X
AB  - We have studied the structure of epidermal keratin filaments polymerized in vitro, addressing two different levels of organization. First, we have determined the amino acid sequence of a mouse epidermal keratin subunit from the nucleotide sequence of a eDNA clone. The subunit contains a large central region, representing about 50 percent, whose sequence strongly suggests that it assumes a coiled-coil α-helical conformation. This is flanked on the amino and carboxyl terminals by long glycine-rich sequences. Second, we have used scanning transmission electron microscopy to study the structure of frozen, unstained filaments. Analyses of such images provides information on the mass per unit length and on the distribution of mass within the filament. These data impose rigorous constraints on possible models for the packing of protofilaments within the filament. Epidermal keratin filaments assembled in vitro are polymorphic; however, the majority of bovine filaments weigh about 37 kD/nm, but most human filaments have masses of only about 27 kD/nm, The filament width is at least 15 nm, substantially more than the generally accepted value of 8 to 10 nm, owing to the existence of low-density mass at the periphery that has not been visualized by conventional microscopic methods. We currently postulate that the α-helical regions of the subunits comprise the structural core or backbone of the filament from which at least some of the glycine-rich sequences protrude. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - KERATIN
KW  - SCANNING transmission electron microscopy
KW  - AMINO acids
KW  - GLYCINE
KW  - SKIN
N1  - Accession Number: 12540757; Steinert, Peter M. 1 Steven, Alasdair C. 2 Roop, Dennis R. 3; Affiliation:  1: Dermatology Branch and Laboratory of Cellular Carcinogenesis, Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, U S A.  2: Laboratory of Physical Biology, National Institute of Arthritis, Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, U S A.  3: Tumor Promotion, National Cancer Institute, Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, U S A.; Source Info: Jul83 Supplement, Vol. 81, p86s; Subject Term: EPIDERMIS; Subject Term: KERATIN; Subject Term: SCANNING transmission electron microscopy; Subject Term: AMINO acids; Subject Term: GLYCINE; Subject Term: SKIN; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12540757
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dale, Beverly A.
AU  - Scofield, Julie A. Haugen
AU  - Hennings, Henry
AU  - Stanley, John R.
AU  - Yuspa, Stuart H.
T1  - Identification of Filaggrin in Cultured Mouse Keratinocytes and Its Regulation by Calcium.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/07/15/Jul83 Supplement
VL  - 81
M3  - Article
SP  - 90s
EP  - 95s
SN  - 0022202X
AB  - Filaggrin is a histidine-rich cationic protein present in cells of the stratum corneum in vivo and derived from a precursor in keratohyalin granules. Biochemical and immunologic methods were used to determine the presence of filaggrin in keratinocytes cultured in vitro and induced to differentiate by increasing the extracellular calcium concentration from 0.07 to 1.2 m<em>M</em>. Indirect immunofluorescence using antibody to rat filaggrin was negative in cells cultured in low-calcium medium but positive in cells switched to high-calcium medium. Large immunofluorescent granules were identified in a perinuclear distribution starting at 6 hours after the shift in calcium concentration, coinciding with the time of appearance of phase-dense cytoplasmic granules. Radiolabeled histidine was preferentially incorporated into proteins of 95, 37, and 27 K. The 37 and 27 K bands were not adsorbed by DE52 cellulose and therefore are cationic. A 27 K cationic, histidine-labeled protein was readily extracted from frozen pellets of cells cultured in high-calcium medium. It comigrates with purified mouse filaggrin (27 K) and reacts with antibody to rat filaggrin on immunoautoradiography. Only trace amounts of this protein could be detected in cells cultured in low-calcium medium. Our observation of filaggrin-immunoreactive granules confirms the previous ultrastructural identification of keratohyalin granules after the shift to high-calcium medium. The results suggest that filaggrin synthesis is stimulated in keratinocytes induced to differentiate by the shift to high extracellular calcium concentration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MICE
KW  - KERATINOCYTES
KW  - CALCIUM
KW  - CELLS
KW  - CELLULOSE
KW  - PROTEINS
N1  - Accession Number: 12540769; Dale, Beverly A. 1,2 Scofield, Julie A. Haugen 1 Hennings, Henry 3 Stanley, John R. Yuspa, Stuart H. 3; Affiliation:  1: Departments of Periodontics, University of Washington, Seattle, Washington.  2: Department of  Medicine (Dermatology), University of Washington, Seattle, Washington.  3: In Vitro Pathogenesis Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Mary/and.; Source Info: Jul83 Supplement, Vol. 81, p90s; Subject Term: MICE; Subject Term: KERATINOCYTES; Subject Term: CALCIUM; Subject Term: CELLS; Subject Term: CELLULOSE; Subject Term: PROTEINS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12540769
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Roop, Dennis R.
AU  - Hawley-Nelson, Pamela
AU  - Cheng, Christina K.
AU  - Vuspa, Stuart H.
T1  - Expression of Keratin Genes in Mouse Epidermis and Normal and Malignantly Transformed Epidermal Cells in Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/07/15/Jul83 Supplement
VL  - 81
M3  - Article
SP  - 144s
EP  - 149s
SN  - 0022202X
AB  - Complementary DNA (cDNA) clones constructed to the 55, 59 and 67 kilodalton (K) keratins, the major keratins synthesized in newborn mouse epidermis, were used as molecular hybridization probes to examine the expression of these genes in newborn epidermis and normal and malignantly transformed epidermal cells in culture. Transcripts of these three keratin genes are abundant in newborn epidermis. However, primary cultures of epidermal cells contain very low levels of these RNAs, The decreased expression of these keratin genes in primary cells appears to be due to factors within the culture system. Unlike primary-cell cultures, the malignantly transformed cell line Pam 212 synthesizes keratin proteins and mRNAs similar to newborn epidermis, including the 67 K keratin, However, synthesis of the 67 K keratin in Pam 212 cells is modulated by culture factors. Keratin gene expression in another Pam line, 321, differs from that of Pam 212 cells in that decreased expression of these three keratin genes occurs. These results indicate that keratin genes that are normally expressed in vivo in epidermis may be expressed in malignant epidermal cells under conditions that do not permit expression of these genes in nonmalignant primary epidermal cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATIN
KW  - GENES
KW  - MICE
KW  - EPIDERMIS
KW  - CELL culture
KW  - CELL lines
N1  - Accession Number: 12540939; Roop, Dennis R. 1 Hawley-Nelson, Pamela 1 Cheng, Christina K. Vuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jul83 Supplement, Vol. 81, p144s; Subject Term: KERATIN; Subject Term: GENES; Subject Term: MICE; Subject Term: EPIDERMIS; Subject Term: CELL culture; Subject Term: CELL lines; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12540939
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12540939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yuspa, Stuart H.
AU  - Kulesz-Martin, Molly
AU  - Ben, Theresa
AU  - Hennings, Henry
T1  - Transformation of Epidermal Cells in Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/07/15/Jul83 Supplement
VL  - 81
M3  - Article
SP  - 162s
EP  - 168s
SN  - 0022202X
AB  - Studies performed on mouse skin have indicated that chemical carcinogenesis can be subdivided into two distinct stages, initiation and promotion. Initiation results from exposure to a classical mutagenic carcinogen and is irreversible even after a single exposure. The permanently altered initiated cell and its progeny may never form a tumor or in any way be recognizable in the target tissue, Exposure to tumor promoters permits the expression of the neoplastic change in initiated cells, and tumors develop. In contrast to initiators, promoters must be given repeatedly to be effective; individual exposures are reversible, A similar biology is suggested by epidemiologic studies of certain human cancers, particularly lung, breast, colon, and uterine malignancies. Studies in mouse skin cell culture have provided new insights into the changes associated with initiation and promotion. Initiated cells appear to be resistant to signals for terminal differentiation and can proliferate under conditions where normal epidermal cells are obligated to cease proliferation and begin their maturation program. This change is essential for an epithelial tumor cell since it provides the ability to grow away from a basement- membrane attachment site, In cultured epidermal cells, tumor promoters are capable of selectively stimulating the growth of certain cells, including initiated cells, while simultaneously inducing terminal differentiation in other epidermal cells, The net effect of these responses to promoters is the clonal expansion of cells stimulated to proliferate. In this way, promoters are capable of increasing the clone size of initiated cells. These cell culture data provided a biological framework for under- standing initiation and promotion in terminally differentiating epithelial tissues. [ABSTRACT FROM AUTHOR]
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KW  - EPIDERMIS
KW  - CELLS
KW  - CARCINOGENESIS
KW  - TUMORS
KW  - MICE
KW  - EPITHELIAL cells
N1  - Accession Number: 12540999; Yuspa, Stuart H. 1 Kulesz-Martin, Molly 1 Ben, Theresa 1 Hennings, Henry 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U S A.; Source Info: Jul83 Supplement, Vol. 81, p162s; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: CARCINOGENESIS; Subject Term: TUMORS; Subject Term: MICE; Subject Term: EPITHELIAL cells; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12540999
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DB  - aph
ER  - 

TY  - JOUR
AU  - DOOLITTLE, RUSSELL F.
AU  - HUNKAPIWLER, MICHAEL W.
AU  - HOOD, LEROY E.
AU  - DEVARE, SUSHILKUMAR G.
AU  - ROBBINS, KEITH C.
AU  - AARONSON, STUART A.
AU  - ANTONIADES, HARRY N.
T1  - Simian Sarcoma Virus onc Gene, v-sis, Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor.
JO  - Science
JF  - Science
Y1  - 1983/07/15/
VL  - 221
IS  - 4607
M3  - Article
SP  - 275
EP  - 277
SN  - 00368075
AB  - The transforming protein of a primate sarcoma virus and a plateletderived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derivedfrom the simian sarcoma virus onc gene, vsis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672938; DOOLITTLE, RUSSELL F. 1; HUNKAPIWLER, MICHAEL W. 2; HOOD, LEROY E. 2; DEVARE, SUSHILKUMAR G. 3; ROBBINS, KEITH C. 3; AARONSON, STUART A. 3; ANTONIADES, HARRY N. 4; Affiliations: 1: Department of Chemistry, University of California, San Diego, La Jolla 92093; 2: Division of Biology, California Institute of Technology, Pasadena 91125; 3: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; 4: Center for Blood Research and Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115; Issue Info: 7/15/1983, Vol. 221 Issue 4607, p275; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - KALEBIC, TEA
AU  - GARBISA, S.
AU  - GLASER, B.
AU  - LIOTTA, L. A.
T1  - Basement Membrane Collagen: Degradation by Migrating Endothelial Cells.
JO  - Science
JF  - Science
Y1  - 1983/07/15/
VL  - 221
IS  - 4607
M3  - Article
SP  - 281
EP  - 283
SN  - 00368075
AB  - One of thefirst steps in neovascularizaton is dissolution of the basement membrane at the point of endothelial outgrowth. An assay was developed to determine whether basement membrane collagens (types IV and V) are degraded by endothelial cells migrating toward a chemotactic stimulus. Fetal bovine endothelial cells were placed on one side of a filter containing the collagen substrate, and a chemoattractant derived from retinal extracts was placed on the opposite side. Degradation of both type IV and type V collagens was observed when the retinal factor was placed on the side of the filter opposite the endothelial cells. Metalloproteinases that cleaved type IV and type V collagens could be extracted from the endothelial cells with detergents. Such endothelial cell-associated (possibly membrane- bound) proteinases may locally disrupt the basement membrane andfacilitate the outgrowth of capillary sprouts toward the angiogenic stimulus [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672941; KALEBIC, TEA 1; GARBISA, S. 2; GLASER, B. 3; LIOTTA, L. A. 4; Affiliations: 1: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20205; 2: Institute of Histology, Padova, Italy; 3: Department of Ophthalmolc Johns Hopkins University, Baltimore, Maryland 21205; 4: Laboratory of Pathology, National Cancer Institute; Issue Info: 7/15/1983, Vol. 221 Issue 4607, p281; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - CHOI, EDMUND
AU  - MCINTYRE, KATHERINE
AU  - GERMAIN, RONALD N.
AU  - SEIDMAN, J. G.
T1  - Murine I-Aβ Chain Polymorphism: Nucleotide Sequences of Three Allelic I-Aβ Genes.
JO  - Science
JF  - Science
Y1  - 1983/07/15/
VL  - 221
IS  - 4607
M3  - Article
SP  - 283
EP  - 286
SN  - 00368075
AB  - The polymorphism of immune response genes plays a critical role in determining the immune capabilities of a particular individual. The molecular nature of this polymorphism was studied by examining the structure of the coding portions of three alleles of the I-AP chain gene, an immune response gene whose protein product constitutes a subunit of the I-A molecule. Comparison of the I-AP chains encoded by these alleles revealed an amino acid sequence divergence of S to 8 percent. The differences werefound to be a series of short alterations clustered in the amino terminal half of the polypeptide. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672942; CHOI, EDMUND 1; MCINTYRE, KATHERINE 1; GERMAIN, RONALD N. 2; SEIDMAN, J. G. 3; Affiliations: 1: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Genetics, Harvard Medical School; Issue Info: 7/15/1983, Vol. 221 Issue 4607, p283; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WEINGARTNER, HERBERT
AU  - GRAFMAN, JORDAN
AU  - BOUTELLE, WILLIAM
AU  - KAYE, WALTER
AU  - MARTIN, PETER R.
T1  - Forms of Memory Failure.
JO  - Science
JF  - Science
Y1  - 1983/07/22/
VL  - 221
IS  - 4608
M3  - Article
SP  - 380
EP  - 382
SN  - 00368075
AB  - Memory may fail in a variety of ways. Patients with Korsakoff's syndrome demonstrate global memory deficits similar to those seen in patients with early progressive dementia. Korsakoff's patients, however, may recall rules and principles for organizing information and can gain access to their previously acquired knowledge (semantic memory), whereas recent memory may be grossly impaired. In contrast, dementia patients may have little access to previously acquired knowledge and therefore have great difficulty in organizing and encoding ongoing events. These contrasting forms of memory failure have implications for understanding the structure and mechanisms of memory and learning, particularly the relationship between episodic and semantic memory, as well as the development of therapeutic strategies for cognitive impairments. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672983; WEINGARTNER, HERBERT 1; GRAFMAN, JORDAN 2; BOUTELLE, WILLIAM 3; KAYE, WALTER 4; MARTIN, PETER R. 5; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; 2: Walter Reed Army Medical Center, Washington, D.C. 20307; 3: Veterans Administration Hospital, Northampton, Massachusetts 01060; 4: National Institute of Mental Health; 5: National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20205; Issue Info: 7/22/1983, Vol. 221 Issue 4608, p380; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - O'BRIEN, STEPHEN J.
AU  - WILDT, DAVID E.
AU  - GOLDMAN, DAVID
AU  - MERRIL, CARL R.
AU  - BUSH, MITCHELL
T1  - The Cheetah Is Depauperate in Genetic Variation.
JO  - Science
JF  - Science
Y1  - 1983/07/29/
VL  - 221
IS  - 4609
M3  - Article
SP  - 459
EP  - 462
SN  - 00368075
AB  - A sample of 55 South African cheetahs (Acinonyx jubatus jubatus) from two geographically isolated populations in South Africa were found to be genetically monomorphic at each of 47 allozyme (allelic isozyme) loci. Two-dimensional gel electrophoresis of 155 abundant soluble proteins from cheetah fibroblasts also revealed a low frequency of polymorphism (average heterozygosity, 0.013). Both estimates are dramatically lower than levels of variation reported in other cats and mammals in general. The extreme monomorphism may be a consequence of a demographic contraction of the cheetah (a population bottleneck) in association with a reduced rate of increase in the recent natural history of this endangered species. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84673021; O'BRIEN, STEPHEN J. 1; WILDT, DAVID E. 1; GOLDMAN, DAVID 2; MERRIL, CARL R. 3; BUSH, MITCHELL 4; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health; 4: National Zoological Park, Smithsonian Institution, Washington, D.C. 20008; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p459; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - HATCH, CHRISTOPHER L.
AU  - BONNER, WILLIAM M.
AU  - MOUDRIANAKIS, EVANGELOS N.
T1  - Minor Histone 2A Variants and Ubiquinated Forms in the Native H2A:H2B Dimer.
JO  - Science
JF  - Science
Y1  - 1983/07/29/
VL  - 221
IS  - 4609
M3  - Article
SP  - 468
EP  - 470
SN  - 00368075
AB  - Histone octamers from calf thymus were separated into (H3:H4)2 tetramers and H2A:H2B dimers by chromatography through Sephadex GIOO. The tetramers and dimers were analyzedfor variants, ubiquitin adducts, and proteolyzed forms. The minor histone variants H2A.X and H2A.Z were found to be associated with histone H2B as H2A.X:H2B and H2A.Z:H2B dimers, respectively. Ubiquitin adducts of the H2A's and H2B were also present in H2A:H2B dimers. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84673025; HATCH, CHRISTOPHER L. 1; BONNER, WILLIAM M. 2; MOUDRIANAKIS, EVANGELOS N. 3; Affiliations: 1: Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218; 2: Laboratory of Molecular Pharmacology, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 3: Department of Biology, Johns Hopkins University; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p468; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - WEINGARTNER, HERBERT
AU  - RUDORFER, MATTHEW V.
AU  - BUCHSBAUM, MONTE S.
AU  - LINNOILA, MARKKU
T1  - Effects of Serotonin on Memory Impairments Produced by Ethanol.
JO  - Science
JF  - Science
Y1  - 1983/07/29/
VL  - 221
IS  - 4609
M3  - Article
SP  - 472
EP  - 474
SN  - 00368075
AB  - Subjects treated with low or high doses of ethanol demonstrated impaired memory, particularly in tests involving the recall of poorly learned information. Zimelidine, an inhibitor of serotonin reuptake, reversed this ethanolinduced impairment. The serotonin neurotransmitter system may mediate learning and memory in humans and may determine some of the effects of alcohol on higher mental functions. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84673027; WEINGARTNER, HERBERT 1; RUDORFER, MATTHEW V. 1; BUCHSBAUM, MONTE S. 2; LINNOILA, MARKKU 3; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Psychiatry, University of California, Irvine 92717; 3: National Institute of Alcoholism and Alcohol Abuse, Bethesda, Maryland 20205; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p472; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - GARRICK, NANCY A.
AU  - TAMARKIN, LAWRENCE
AU  - TAYLOR, PHILIP L.
AU  - MARKEY, SANFORD P.
AU  - MURPHY, DENNIS L.
T1  - Light and Propranolol Suppress the Nocturnal Elevation of Serotonin in the Cerebrospinal Fluid of Rhesus Monkeys.
JO  - Science
JF  - Science
Y1  - 1983/07/29/
VL  - 221
IS  - 4609
M3  - Article
SP  - 474
EP  - 476
SN  - 00368075
AB  - Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinalfluid were reduced to daytime levels by exposing the monkeys to continuous light or to the, -adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84673028; GARRICK, NANCY A. 1,2; TAMARKIN, LAWRENCE 3; TAYLOR, PHILIP L. 4; MARKEY, SANFORD P. 5; MURPHY, DENNIS L. 6; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Physiology Division, Department of Zoology, University of Maryland, College Park 20742; 3: Intramural Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 4: MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, EH3 9EW Scotland; 5: Laboratory of Clinical Science, National Institute of Mental Health; 6: Clinical Neuropharmacology Branch, National Institute of Mental Health; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p474; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Chrest, F. J.
AU  - Nagel, J. E.
AU  - Pyle, R. S.
AU  - Adler, W. H.
T1  - Human B cell function in responder and non-responder indiviuals. II. The role of T helper cells in promoting the PWM-induced B cell production of immunoprotein.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1983/08//
VL  - 53
IS  - 2
M3  - Article
SP  - 465
EP  - 472
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Sorted OKT4+ cells treated with pokeweed mitogen (PWM) and subsequently X-irradiated were used as a source of helper T cells to examine human T and B cell function. PWM-induced immunoprotein synthesis by human peripheral blood lymphocytes was the model used to study cellular interactions. PWM was shown to induce helper T cell function which caused non-PWM treated B cells to secrete immunoglobulin. PBL from certain individuals could not be induced by PWM to secrete Ig therefore allogeneic co-cultures of helper T cells and B cells were examined to define the defective cell population. Ig synthesis allogeneic cultures of T and B cells was always greater than that observed in autologous cultures when cells from responders were assayed. However, when allogenic cultures were initiated using B cells from a responder and PWM treated T cells from a non-responder and examined for Ig synthesis, the B cell responses were markedly lower than seen in the autologous responder cultures. In addition, PWM activated helper T cells from a responder induced a significantly higher Ig synthesis by B cells from a non-responder. These observations indicate that PBL from individuals who do not respond in a PWM driven Ig synthesis assay have relatively normal B cell function but are deficient in helper T cell function. [ABSTRACT FROM AUTHOR]
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KW  - POKEWEED mitogens
KW  - B cells
KW  - T cells
KW  - PROTEINS
KW  - LEUCOCYTES
KW  - IMMUNOGLOBULINS
KW  - B cell function
KW  - helper T cells
KW  - pokeweed mitogen
N1  - Accession Number: 16017343; Chrest, F. J. 1 Nagel, J. E. 1 Pyle, R. S. 1 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Baltimore, USA.; Source Info: Aug1983, Vol. 53 Issue 2, p465; Subject Term: POKEWEED mitogens; Subject Term: B cells; Subject Term: T cells; Subject Term: PROTEINS; Subject Term: LEUCOCYTES; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: B cell function; Author-Supplied Keyword: helper T cells; Author-Supplied Keyword: pokeweed mitogen; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Stevenson, H. C.
AU  - Miller, P. J.
AU  - Waxdal, M. J.
AU  - Haynes, B. F.
AU  - Thomas, C. A.
AU  - Fauci, A. S.
T1  - Interaction of pokeweed mitogen with monocytes in the activation of human lymphocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1983/08//
VL  - 49
IS  - 4
M3  - Article
SP  - 633
EP  - 640
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The present study examines the role of monocytes in the in-vitro activation of human T cells and B cells by pokeweed mitogen (PWM). The T cell-dependent PWM-induced B-cell activation process was found to be monocyte dependent. Fluorescence-activated cell sorter (FACS) analysis revealed that upon addition to peripheral blood mononuclear cells, fluoresceinated PWM, at concentrations that provided optimal B-cell and T-cell activation, bound predominantly to human monocytes. The binding of PWM to monocytes was reversible and could be displaced within the first few hours of binding by oligomers of N-acetylglucosamine (GlcNAc). As a functional correlate of the binding studies, it was shown that PWM-pulsed monocytes could induce B lymphocytes to become plaque-forming cells (PFC) and T lymphocytes to undergo proliferation. In contrast, markedly reduced PFC and blastogenic responses were observed when monocyte-depleted B lymphocytes and T lymphocytes were respectively pulsed with PWM and washed, followed by the addition of non-PWM-pulsed monocytes to the cultures. Thus, the initial event in the PWM-induced activation of human lymphocytes, for both in-vitro T-lymphocyte blastogenic responses and B-lymphocyte Ig secretion, appears to be binding of the mitogen to sugar residues on the surface membrane of the monocyte, followed by subsequent interaction with the appropriate lymphocytes. The process of PWM binding to monocytes did not appear to affect the baseline production of interleukin-1 (IL-1) by human monocytes, nor could soluble factors from PWM-pulsed monocytes substitute for intact cells in the initiation of the lymphocyte-activation process. [ABSTRACT FROM AUTHOR]
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KW  - MONOCYTES
KW  - T cells
KW  - POKEWEED mitogens
KW  - PLANT lectins
KW  - INTERLEUKINS
KW  - OLIGOMERS
N1  - Accession Number: 13523299; Stevenson, H. C. 1 Miller, P. J. 1 Waxdal, M. J. 1 Haynes, B. F. 1 Thomas, C. A. 1 Fauci, A. S. 2; Affiliation:  1: Biological Therapeutics Branch, Biological Response Modifiers Program, National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland and Laboratory of Immunoregulation and Laboratory of Immunology, National Institute of Allergy.  2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug83, Vol. 49 Issue 4, p633; Subject Term: MONOCYTES; Subject Term: T cells; Subject Term: POKEWEED mitogens; Subject Term: PLANT lectins; Subject Term: INTERLEUKINS; Subject Term: OLIGOMERS; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Woodley, David
AU  - Sauder, Daniel
AU  - Talley, Mary Jane
AU  - Silver, Michael
AU  - Grotendorst, Gary
AU  - Qwarnstrom, Eva
T1  - Localization of Basement Membrane Components After Dermal-Epidermal Junction Separation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/08//
VL  - 81
IS  - 2
M3  - Article
SP  - 149
EP  - 153
SN  - 0022202X
AB  - Adult human skin was separated at the dermal-epidermal junction (DEJ) by 4 published methods that involved different mechanisms of action: cold 1 M salt (tissue extraction), cold trypsinization (enzymatic), induction of a suction blister (mechanical), and warm phosphate- buffered saline (protease activation). The localization of DEJ macromolecules was studied after each separation method. By all of the methods tested, bullous pemphigoid antigen remained closely associated with the epidermis while laminin, the basement membrane heparan sulfate proteoglycan, and collagen types IV and V remained with the dermal side of the separation. The bullous pemphigoid antigen is, then, the DEJ component most closely associated with the epidermal basal cell. Of the basement membrane components tested, only the basement membrane heparan sulfate proteoglycan was trypsin-sensitive. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - DERMIS
KW  - ANTIGENS
KW  - PROTEOGLYCANS
KW  - COLLAGEN
KW  - TRYPSIN
N1  - Accession Number: 12543517; Woodley, David 1 Sauder, Daniel 2 Talley, Mary Jane 2 Silver, Michael 1 Grotendorst, Gary 1 Qwarnstrom, Eva 1; Affiliation:  1: Laboratory of Developmental Biology and Anomalies, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: National Institute of Dental Research and Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug83, Vol. 81 Issue 2, p149; Subject Term: EPIDERMIS; Subject Term: DERMIS; Subject Term: ANTIGENS; Subject Term: PROTEOGLYCANS; Subject Term: COLLAGEN; Subject Term: TRYPSIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12543517
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GORMAN, CORNELIA
AU  - PADMANABHAN, RAJI
AU  - HOWARD, BRUCE H.
T1  - High Efficiency DNA-Mediated Transformation of Primate Cells.
JO  - Science
JF  - Science
Y1  - 1983/08/05/
VL  - 221
IS  - 4610
M3  - Article
SP  - 551
EP  - 553
SN  - 00368075
AB  - Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyl transferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10-3 (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 × 10-2 (6 percent). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673067; GORMAN, CORNELIA 1; PADMANABHAN, RAJI 1; HOWARD, BRUCE H. 1; Affiliations: 1: Laboratory of Molecular Biology, Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 8/ 5/1983, Vol. 221 Issue 4610, p551; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - ROWE, WALLACE P.
T1  - Deformed Whiskers in Mice Infected with Certain Exogenous Murine Leukemia Viruses.
JO  - Science
JF  - Science
Y1  - 1983/08/05/
VL  - 221
IS  - 4610
M3  - Article
SP  - 562
EP  - 564
SN  - 00368075
AB  - Mice infected at birth with replication competent Friend, Moloney, Cas- Br-M, C2S-M, and 1504-A murine leukemia viruses developed abnormalities of the vibrissae consisting of erratic curvature, shortening, and loss. A number of other virus strains, as well as endogenous AKR-type ecotropic virus and AKR-type, mink cellfocus-inducing (MCF) viruses, did not produce these abnormalities. In mice with erythroid and myeloid leukemia, the perivibrissal sinus is the site of extramedullary hematopoiesis, but this did not appear to be the basis of the deformities. Genetic evidence indicated that newly arisen MCF-type recombinant viruses are involved in the pathogenesis of the abnormalities, at least with some of the virus systems studied. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84673072; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Issue Info: 8/ 5/1983, Vol. 221 Issue 4610, p562; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NAMBOODIRI, M. A. A.
AU  - SUGDEN, D.
AU  - KLEIN, D. C.
AU  - MEFFORD, I. N.
T1  - 5-Hydroxytryptophan Elevates Serum Melatonin.
JO  - Science
JF  - Science
Y1  - 1983/08/12/
VL  - 221
IS  - 4611
M3  - Article
SP  - 659
EP  - 661
SN  - 00368075
AB  - Daytime administration of 5-hydroxytryptophan to sheep elevated serum melatonin more than sevenfold within 2 hours. This suggests that administration of 5-hydroxytryptophan could be used as the basis of a clinical test of pineal function and that melatonin might mediate some clinical effects of 5-hydroxytryptophan. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 85483660; NAMBOODIRI, M. A. A. 1; SUGDEN, D. 1; KLEIN, D. C. 1; MEFFORD, I. N. 2; Affiliations: 1: Section, Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02167; Issue Info: 8/12/1983, Vol. 221 Issue 4611, p659; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Barneveld, Ruud A.
AU  - Tegelaers, Frans P. W.
AU  - Ginns, Edward I.
AU  - Visser, Pim
AU  - Laanen, Elly A.
AU  - Brady, Roscoe O.
AU  - Galjaard, Hans
AU  - Barranger, John A.
AU  - Reuser, Arnold J. J.
AU  - Tager, Joseph M.
T1  - Monoclonal Antibodies against Human β-Glucocerebrosidase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/08/15/
VL  - 134
IS  - 3
M3  - Article
SP  - 585
EP  - 589
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Monoclonal antibodies were obtained against the membrane-bound lysosomal enzyme β-glucocerebrosidase (acid β-glucosidase), which is deficient in Gaucher's disease.  BALB/c mice were immunized with homogeneous enzyme protein extracted from a sodium dodecyl sulphate/polyacrylamide gel. The mice were subsequently hyperimmunized with partially purified enzyme prior to fusion of spleen cells with myeloma cells. After fusion, 32 primary hybrid cell populations were obtained which continued to produce antibodies against β-glucocerebrosidase after prolonged time of culture. All antibodies reacted with both native and denatured enzyme.  Four primary cell populations were subcloned and the antibodies produced were characterized. The antibodies were all four of the IgG1 subclass. Three of these antibodies bind to protein A whereas one does not. The results of binding assays indicated that three of the antibodies react with the same antigenic domain (epitope 1), but the fourth with a different one (epitope 2). Probably two antigenic determinants are present in epitope 1 since one of the antibodies with specificity for epitope 1 is inactivated after iodination by the chloramine-T procedure whereas a second one is not. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - CELL membranes
KW  - GAUCHER'S disease
KW  - ENZYMES
KW  - MYELOMA proteins
N1  - Accession Number: 13918899; Barneveld, Ruud A. 1 Tegelaers, Frans P. W. 2 Ginns, Edward I. 3 Visser, Pim 1 Laanen, Elly A. 2 Brady, Roscoe O. 3 Galjaard, Hans 1 Barranger, John A. 3 Reuser, Arnold J. J. 1 Tager, Joseph M. 2; Affiliation:  1: Department of Cell Biology and Genetics Erasmus University Rotterdam  2: Laboratory of Biochemistry University of Amsterdam  3: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda; Source Info: 8/15/83, Vol. 134 Issue 3, p585; Subject Term: MONOCLONAL antibodies; Subject Term: CELL membranes; Subject Term: GAUCHER'S disease; Subject Term: ENZYMES; Subject Term: MYELOMA proteins; Number of Pages: 5p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - SCHWARTZ, M.
AU  - DUARA, R.
AU  - HAXBY, J.
AU  - GRADY, C.
AU  - WHITE, B. J.
AU  - KESSLER, R. M.
AU  - KAY, A. D.
AU  - CUTLER, N. R.
AU  - RAPOPORT, S. I.
T1  - Down's Syndrome in Adults: Brain Metabolism.
JO  - Science
JF  - Science
Y1  - 1983/08/19/
VL  - 221
IS  - 4612
M3  - Article
SP  - 781
EP  - 783
SN  - 00368075
AB  - The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a Si-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673121; SCHWARTZ, M. 1; DUARA, R. 1; HAXBY, J. 1; GRADY, C. 1; WHITE, B. J. 2; KESSLER, R. M. 3; KAY, A. D. 4; CUTLER, N. R. 4; RAPOPORT, S. I. 4; Affiliations: 1: Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Cell Biology and Genetics, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health; 3: Department of Nuclear Medicine, National Institutes of Health; 4: Laboratory of Neurosciences, National Institute on Aging; Issue Info: 8/19/1983, Vol. 221 Issue 4612, p781; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - LAUTENBERGER, JAMES A.
AU  - ULSH, LINDA
AU  - SHIH, THOMAS Y.
AU  - PAPAS, TAKiS S.
T1  - High-Level Expression in Escherichia coli of Enzymatically Active Harvey Murine Sarcona Virus p21 ras Protien.
JO  - Science
JF  - Science
Y1  - 1983/08/26/
VL  - 221
IS  - 4613
M3  - Article
SP  - 858
EP  - 860
SN  - 00368075
AB  - The gene for the Harvey murine sarcoma virus (Ha-MuSV) p2lras protein was fused to the amino-terminal portion of the bacteriophage λ cII gene on the expression vector pJL6. Thefusion was such tht transcription was controlled by the well-regulated phage λPL promoter, and translation initiated in the cII gene continued in frame into the ras gene, sequences that code for p21. When the PL promoter was derepressed, the Escherichia coli cells harboring the fusion plasmid synthesized 23,000-dalton protein, which represented more than 10 percent of the total cellular protein. This protein was chimeric and contained 14 residues, which were specified by the vector; these residues-were followed by all of the amino acids that make up Ha-MuSV p2lras except for four residues at the amino-terminal end. The protein appears similar to Ha-MuSV p21ras in that it undergoes immunoprecipitation by monoclonal antibodies directed toward that protein, binds guanosine diphosphate, and is capable of autophosphorylation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673151; LAUTENBERGER, JAMES A. 1; ULSH, LINDA 1; SHIH, THOMAS Y. 1; PAPAS, TAKiS S. 1; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Bethesda, Maryland 2Q205; Issue Info: 8/26/1983, Vol. 221 Issue 4613, p858; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - KOZAK, CHRISTINE A.
AU  - SEARS, JOHNNA F.
AU  - HOGGAN, M. DAVID
T1  - Genetic Mapping of the Mouse Proto-Oncogene c-sis to Chromosome 15.
JO  - Science
JF  - Science
Y1  - 1983/08/26/
VL  - 221
IS  - 4613
M3  - Article
SP  - 867
EP  - 869
SN  - 00368075
AB  - The mouse homolog (c-sis) of the transforming gene of the simian sarcoma virus was mapped to chromosome 15 by the Southern blot analysis of DNA'sfrom hamster-mouse somatic cell hybrids. Alterations in c-sis expression may thus play a role in the various murine neoplastic diseases characterized by rearrangements or duplications of chromosome 15. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673155; KOZAK, CHRISTINE A. 1; SEARS, JOHNNA F. 1; HOGGAN, M. DAVID 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/26/1983, Vol. 221 Issue 4613, p867; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - ROSENSTEIN, JEFFREY M.
AU  - BRIGHTMAN, MILTON W.
T1  - Circumventing the Blood-Brain Barrier with Autonomic Ganglion Transplants.
JO  - Science
JF  - Science
Y1  - 1983/08/26/
VL  - 221
IS  - 4613
M3  - Article
SP  - 879
EP  - 881
SN  - 00368075
AB  - Superior cervical ganglia, whose vessels are fenestrated and permeable to protein tracers such as horseradish peroxidase, were transplanted to undamaged surfaces in the fourth ventricle of rat pup brains. Horseradish peroxidase, infused systemically into the host, was exuded from the graft's vessels into the graft's extracellular stroma within I minute. At later times the glycoprotein reached the extracellular clefts of adjacent brain tissue, the vessels of which appeared to retain their impermeability. The blood-brain barrier to horseradish peroxide was thus bypassed where the extracellular compartments of graft and brain became confluent. The graft of autonomic ganglia can serve as a portal through which peptides, hormones, and immunoglobulins may likewise enter the brain [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673161; ROSENSTEIN, JEFFREY M. 1; BRIGHTMAN, MILTON W. 2; Affiliations: 1: Department ofAnatomy, George Washington University Medical Center, Washington, D.C. 20037; 2: Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/26/1983, Vol. 221 Issue 4613, p879; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Kovar, Mary Grace
AU  - Hiller, Rita
AU  - Krueger, Eean E.
AU  - Green, Lawrence W.
AU  - Bauer, Katherine G.
AU  - Gordon, Nancy P.
AU  - Belcastro, Philip A.
AU  - Sachs, Michael L.
AU  - Yamamoto, Loren
AU  - Yano, Katsuhiko
T1  - Letters to the Editor.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1983/09//
VL  - 73
IS  - 9
M3  - Letter
SP  - 1101
PB  - American Public Health Association
SN  - 00900036
AB  - Several letters to the editor are presented in response to articles in previous issues including "Beyond the Statistics of Adolescent Smoking," by P. Eckert that was published in an issue, "In Support of Jogging," by Dr. M. A. Ibrahim, and the "Editor's Report: LPU, The Nation's Health and Other Matters," by A. Yankauer that was published in an issue.
KW  - LETTERS to the editor
KW  - CIGARETTE smokers
KW  - TEENAGERS
KW  - JOGGING
KW  - MEDICAL policy
KW  - PUBLIC health
N1  - Accession Number: 4948721; Kovar, Mary Grace 1 Hiller, Rita 2 Krueger, Eean E. 3 Green, Lawrence W. 4 Bauer, Katherine G. 5 Gordon, Nancy P. Belcastro, Philip A. 6 Sachs, Michael L. 7 Yamamoto, Loren 8 Yano, Katsuhiko 8; Affiliation:  1: Special Assistant, Data Policy and Analysis Office of Interview and Examination Statistics Program, NCHS, PHS, DHHS, Washington.  2: Office of Biometry and Epidemiology, National Eye Institute, Rockville.  3: Biostatistics Center, George Washington University, Bethesda.  4: Center for Health Promotion, Research, and Development, University of Texas Health Sciences Center, Houston.  5: Scholar-in-Residence, Institute of Medicine, Washington.  6: Assistant Professor, Dept of Health Education, Southern Illinois Univ., Carbondale.  7: Professor, Departement des Sciences de l'activite physique, Universite du Quebec, C.P 500, Quebec.  8: Honolulu Heart Program, Kuakina Medical Center, 347 N. Kuakini St. Honolulu, HI 96817.; Source Info: Sep83, Vol. 73 Issue 9, p1101; Subject Term: LETTERS to the editor; Subject Term: CIGARETTE smokers; Subject Term: TEENAGERS; Subject Term: JOGGING; Subject Term: MEDICAL policy; Subject Term: PUBLIC health; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Small, Arnold
AU  - Madero, James
AU  - Teagno, Lorie
AU  - Ebert, Michael
T1  - INTELLECT, PERCEPTUAL CHARACTERISTICS, AND WEIGHT GAIN IN ANOREXIA NERVOSA.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1983/09//
VL  - 39
IS  - 5
M3  - Article
SP  - 780
EP  - 782
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The article focuses on the study of weight gain among the patients of Anorexia Nervosa. The few investigations in the past decade that have examined the thinking and perceptual processes of anorexics have provided a fairly consistent picture in that they have found striking disturbances in both for a significant number. Researchers studied the results of the age-appropriate Wechsler Scale and the Rorschach of a group of anorexics in an attempt to determine whether psychodiagnostjc indices may be associated with weight gain. 27 subjects were successively admitted anorexics to the behavior modification weight gain program. Multiple regression analyses, using percent weight gain as a continuous criterion, were conducted separately for Wechsler subtest scales and Rorschach determinants. The results of the multiple regression analyses suggest that the Wechsler Scale is more important than perceptual-personality variables in predicting weight gain for anorexics in a behavior modification program.
KW  - WEIGHT gain
KW  - ANOREXIA nervosa
KW  - BODY weight
KW  - MENTAL disabilities
KW  - INTELLIGENCE tests
KW  - REGRESSION analysis
N1  - Accession Number: 19108600; Small, Arnold 1 Madero, James 2 Teagno, Lorie 3 Ebert, Michael 4; Affiliation:  1: George Mason University Family and Child Development Services of Virginia.  2: United States International University.  3: University of Maryland.  4: National Institute of Mental Health.; Source Info: Sep1983, Vol. 39 Issue 5, p780; Subject Term: WEIGHT gain; Subject Term: ANOREXIA nervosa; Subject Term: BODY weight; Subject Term: MENTAL disabilities; Subject Term: INTELLIGENCE tests; Subject Term: REGRESSION analysis; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Riley, Matilda White
T1  - The Family in an Aging Society: A Matrix of Latent Relationships.
JO  - Journal of Family Issues
JF  - Journal of Family Issues
Y1  - 1983/09//
VL  - 4
IS  - 3
M3  - Article
SP  - 439
EP  - 454
SN  - 0192513X
AB  - Because of unprecedented increases in longevity, the kinship structure has been transformed. Linkages among family members have been prolonged, and the surviving generations in a family have increased in number and complexity. Today's kinship structure (which has no parallel in history) can be viewed in a new way: as a latent web of continually shifting linkages that provide the potential for activating and intensifying close family relationships. These relationships are no longer prescribed as strict obligations, but must be earned-created and recreated by family members over their lives. Such changes in the structure and dynamics of family relationships raise many questions and issues for students of the family including the development of special research approaches needed to understand the complexity of these relationships and the nature of older people's family relationships in the future. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FAMILIES
KW  - FAMILY relations
KW  - KINSHIP
KW  - SOCIAL psychology
KW  - AFFINITY (Kinship)
N1  - Accession Number: 13543958; Riley, Matilda White 1; Source Information: Sep1983, Vol. 4 Issue 3, p439; Subject: FAMILIES; Subject: FAMILY relations; Subject: KINSHIP; Subject: SOCIAL psychology; Subject: AFFINITY (Kinship); Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Luger, Thomas A.
AU  - Stadler, Beda M.
AU  - Luger, Bia M.
AU  - Sztein, Marcelo B.
AU  - Schmidt, John A.
AU  - Hawley-Nelson, Pamela
AU  - Grabner, Gunther
AU  - Oppenheim, Joost J.
T1  - Characteristics of an Epidermal Cell Thymocyte-Activating Factor (ETAF) Produced by Human Epidermal Cells and a Human Squamous Cell Carcinoma Cell Line.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/09//
VL  - 81
IS  - 3
M3  - Article
SP  - 187
EP  - 193
SN  - 0022202X
AB  - In this study we show that both cultured normal human epidermal cells (EC) and a human squamous cell carcinoma (SCC) cell line produce a thymocyte-activating factor (ETAF). EC-ETAF and SCC-ETAF both have a Mr of 15,000 and were eluted from chromatofocusing at the same isoelectric points of 7.2, 5.8, and 5.0. Both activities were maintained at alkaline pH and were destroyed at temperatures above 60°C. In addition to stimulating thymocyte proliferation, human ETAF exhibited a variety of other pertinent biologic activities. Although EC-ETAF or SCC-ETAF by themselves exhibited no T-cell growth factor activity, both ETAF preparations enhanced Interleukin 2 production by cultured human peripheral blood lymphocytes when stimulated with polyclonal T-cells stimulants (Concanavalin A and phorbol myristate acetate). Human ETAF also was chemotactic for rabbit polymorphonuclear leukocytes and was directly mitogenic for cultured human dermal fibroblasts. Injection of human ETAF into C3H/HeJ mice, resulted in inducing serum amyloid A (SAA) production by murine hepatocytes. The thymocyte growth-enhancing activity, the fibroblast-stimulating activity, and the SAA-inducing capacity of ETAF all coeluted off AcA54 gel. These biologic as well as biochemical properties of human keratinocyte-derived ETAF are identical with those of human macrophage-derived Interleukin 1. The ability of keratinocytes to release an immunomodulating factor with such diverse consequences may play an important role in normal wound healing and in diseases involving epithelial tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUAMOUS cell carcinoma
KW  - T cells
KW  - LYMPHOCYTES
KW  - BLOOD
KW  - CANCER cells
KW  - LEUCOCYTES
N1  - Accession Number: 12517658; Luger, Thomas A. 1,2,3,4 Stadler, Beda M. 1,2,3,4 Luger, Bia M. 1,2,3,4 Sztein, Marcelo B. 1,2,3,4 Schmidt, John A. 1,2,3,4 Hawley-Nelson, Pamela 1,2,3,4 Grabner, Gunther 1,2,3,4 Oppenheim, Joost J.; Affiliation:  1: Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland.  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.  3: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  4: Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, California, U.S.A.; Source Info: Sep83, Vol. 81 Issue 3, p187; Subject Term: SQUAMOUS cell carcinoma; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: BLOOD; Subject Term: CANCER cells; Subject Term: LEUCOCYTES; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12517658
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DB  - aph
ER  - 

TY  - JOUR
AU  - ROBISON JR., W. GERALD
AU  - KADOR, PETER F.
AU  - KINOSHITA, JIN H.
T1  - Retinal Capillaries: Basement Membrane Thickening by Galactosemia Prevented with Aldose Reductase Inhibitor.
JO  - Science
JF  - Science
Y1  - 1983/09/16/
VL  - 221
IS  - 4616
M3  - Article
SP  - 1177
EP  - 1179
SN  - 00368075
AB  - A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase. Since the basement membrane thickening was ultrastructurally similar to that typical of diabetic retinopathy, it may indicate changes in vessel permeability and susceptibility to hemorrhage. Galactosemic rats should be useful models for studying basement membrane-related complications of diabetes and for examining the potential biochemical regulation of basement membrane synthesis by aldose reductase inhibitors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673271; ROBISON JR., W. GERALD 1; KADOR, PETER F. 1; KINOSHITA, JIN H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 9/16/1983, Vol. 221 Issue 4616, p1177; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - JOFFE, JUSTIN M.
AU  - KIMBALL, A. W.
AU  - MUKHERJEE, ANIL B.
AU  - HODGEN, GARY D.
T1  - Alcohol and Pregnancy.
JO  - Science
JF  - Science
Y1  - 1983/09/23/
VL  - 221
IS  - 4617
M3  - Article
SP  - 1244
EP  - 1245
SN  - 00368075
N1  - Accession Number: 84673287; JOFFE, JUSTIN M. 1; KIMBALL, A. W. 2; MUKHERJEE, ANIL B. 3; HODGEN, GARY D. 3; Affiliations: 1: Department of Psychology, Dewey Hall, University of Vermont, Burlington 05405; 2: Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205; 3: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/23/1983, Vol. 221 Issue 4617, p1244; Number of Pages: 2p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - SONDEREGGER, PETER
AU  - FISHMAN, MARK C.
AU  - BOKOUM, MADINA
AU  - BAUER, HANS C.
AU  - NELSON, PHILLIP G.
T1  - Axonal Proteins of Presynaptic Neurons During Synaptogenesis.
JO  - Science
JF  - Science
Y1  - 1983/09/23/
VL  - 221
IS  - 4617
M3  - Article
SP  - 1294
EP  - 1297
SN  - 00368075
AB  - Changes occur in the synthesis and axonal transport of neuronal proteins in dorsal-root ganglia axons as a result of contact with cells from the spinal cord during synapse formation. Dorsal-root ganglia cells were cultured in a compartmental cell culture system that allows separate access to neuronal cell bodies and their axons. When cells from the ventral spinal cord were cultured with the dorsal-root ganglia axons, synapses were established within a few days. Metabolic labeling and two-dimensionat electrophoresis revealed that four of more than 300 axonal proteins had changed in their expression by the time synapses were established. The highly selective nature of these changes suggests that the proteins involved may be important in the processes of axon growth and synapse formation and their regulation by the regional environment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673314; SONDEREGGER, PETER 1; FISHMAN, MARK C. 1; BOKOUM, MADINA 1; BAUER, HANS C. 1; NELSON, PHILLIP G. 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/23/1983, Vol. 221 Issue 4617, p1294; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - MEMO, MAURIZIO
AU  - KLEINMAN, JOEL E.
AU  - HANBAUER, INGEBORG
T1  - Coupling of Dopamine D1 Recognition Sites with Adenylate Cyclase in Nuclei Accumbens and Caudatus of Schizophrenics.
JO  - Science
JF  - Science
Y1  - 1983/09/23/
VL  - 221
IS  - 4617
M3  - Article
SP  - 1304
EP  - 1307
SN  - 00368075
AB  - Sodium fluoride, guanylimidodiphosphate, and the D1 dopamine receptor agonist SKF 38393 elicited a greater activation of adenylate cyclase in homogenates of caudate nucleus in schizophrenic than in nonschizophrenic subjects used as controls. Similarly, a greater activation of adenylate cyclase by sodium fluoride was observed in the nucleus accumbens of schizophrenics. These findings suggest that the coupling of dopamine D1 recognition sites with adenylate cyclase is more efficient in the brain of the schizophrenic, presumably because of an increased affinity of the GIF protein for guanosine 5'-triphosphate. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84673318; MEMO, MAURIZIO 1; KLEINMAN, JOEL E. 2; HANBAUER, INGEBORG 1; Affiliations: 1: Section on Biochemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 2: Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 9/23/1983, Vol. 221 Issue 4617, p1304; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Rennard, S. I.
AU  - Yuang-Fang Chen
AU  - Robbins, R. A.
AU  - Gadek, J. E.
AU  - Crystal, R. G.
T1  - Fibronectin mediates cell attachment to Clq: a mechanism for the localization of fibrosis in inflammatory disease.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1983/10//
VL  - 54
IS  - 1
M3  - Article
SP  - 239
EP  - 247
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Chronic inflammatory processes frequently lead to the abnormal replacement of normal tissue elements by increased numbers of fibroblasts and fibrous connective tissue, i.e., fibrosis. Since the growth of fibroblasts requires that these cells be attached to an extracellular support, the current study was designed to determine if the interaction between the fibroblast attachment factor fibronectin and the Clq component of complement could support fibroblast attachment and growth and thus could form a basis for the attachment of fibroblasts in abnormal tissue locations in those inflammatory states where Clq is bound. Fibronectin purified from human plasma supported attachment of both Chinese hamster ovary cells and of normal fetal lung fibroblasts (HFL-1) to Clq coated substrates. The attachment activity was approximately twice that of attachment to collagen, and was specific, as no attachment occurred to albumin coated substrates. Cells attached to Clq substrates demonstrated characteristic "spreading" similar to those on collagen. Moreover, the Clq substrate resembled collagen in its ability to support fibroblast growth. Further, the ability of the interaction between Clq and fibronectin to mediate attachment of fibroblasts to immune complexes was demonstrated by the formation of fibroblast-red blood cell-immune complex rosettes, a process that was dependent on both fibronectin and Clq, Thus, the interaction between fibronectin and Clq could serve as the basis for fibroblast attachment and growth in abnormal tissue sites where immune complexes are formed and could be a contributing factor to the development of fibrosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FIBROBLASTS
KW  - COLLAGEN
KW  - CONNECTIVE tissues
KW  - EXTRACELLULAR matrix proteins
KW  - IMMUNOGLOBULINS
KW  - BLOOD cells
KW  - cell attachment
KW  - Clq
KW  - Fibronectin
KW  - fibrosis
KW  - immune complexes
N1  - Accession Number: 16308328; Rennard, S. I. 1 Yuang-Fang Chen 1 Robbins, R. A. 1 Gadek, J. E. 1 Crystal, R. G. 1; Affiliation:  1: Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Oct1983, Vol. 54 Issue 1, p239; Subject Term: FIBROBLASTS; Subject Term: COLLAGEN; Subject Term: CONNECTIVE tissues; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD cells; Author-Supplied Keyword: cell attachment; Author-Supplied Keyword: Clq; Author-Supplied Keyword: Fibronectin; Author-Supplied Keyword: fibrosis; Author-Supplied Keyword: immune complexes; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosling, Bengt G.
AU  - Slots, Jørgen
AU  - Webber, Richard L.
AU  - Christersson, Lars A.
AU  - Genco, Robert J.
T1  - Microbiological and clinical effects of topical subgingival antimicrobial treatment on human periodontal disease.
JO  - Journal of Clinical Periodontology
JF  - Journal of Clinical Periodontology
Y1  - 1983/10//
VL  - 10
IS  - 5
M3  - Article
SP  - 487
EP  - 514
SN  - 03036979
AB  - This study was undertaken to evaluate the microbiological and clinical effects of a subgingivally applied mixture of H2O2-NaCl and NaHCO3 followed by subgingival irrigation with 1% Betadine® in the treatment of periodontal disease. 20 adults with moderate to severe periodontal disease were included in a split mouth design study. All patients were given oral hygiene instruction and were subjected to <em>supragingival</em> scaling in all 4 quadrants, and <em>subgingival</em> scaling and root planing of half the dentition. 10 patients were instructed to use the chemical antimicrobial mixture twice a day instead of dentifrice, and also received professional application of the mixture once every 14 days for 3 months in connection with reinstruction in oral hygiene procedures. The remaining 10 patients received oral hygiene instructions combined with professional tooth cleaning without use of chemicals once every 14 days during a 3-month period. The effect of treatment was evaluated by monitoring the subgingival microflora, clinical periodontal parameters, and by computer assisted subtraction analysis of serial standardized radiographs to determine changes in mass of the supporting alveolar bone. The present study revealed that subgingival debridement combined with mechanical plaque control resulted in decreased numbers of subgingival microorganisms including spirochetes and motile rods, and arrested the progressive breakdown of the periodontal tissues. Topical antimicrobial agents used in combination with subgingival scaling further reduced the subgingival microflora and substantially improved early periodontal healing including gain of probing attachment level and gain in radiographic alveolar bone mass during the 12 months of observation. No clinical improvement but a tendency to further periodontal breakdown was found in the unscaled quadrants, even in those which were subjected to a personal application of the topical antimicrobial mixture. This study indicates that professional and personal subgingival application of a mixture of H2O2-NaCl and NaHCO3 will significantly enhance the microbiological and clinical effects of periodontal scaling and root planing. These agents, and the topical mode of antimicrobial therapy seem promising in the management of human periodontal diseases. (English) [ABSTRACT FROM AUTHOR]
AB  - Le but de cette étude a été l'évaluation des effets cliniques et microbiologiques sur la maladie parodontale de l'application sousgingivale d'un mélange de H2O2-NaCl et de NaHCO3suivie d'une irrigation au Betadine® 1%. L'étude a porté sur 20 adultes atteints de maladie parodontale maodérée à sévère dont la bouche a été divisée en 2 quadrants d'expérimentation et 2 quadrants témoins. Tous les patients ont reçu des instructions d'hygiène buccale, un détartrage sousgingival et un lissage radiculaire de 2 quadrants. La moitié des patients a utilisé le mélange antimicrobien chirnique 2 fois par jour à la place de dentifrice et reccedil;u également une application professionnelle de ce mélange toutes les 2 semaines durant 3 mois et des instructions renouvelées d'hygiène buccale. L'autre moitié des patients a reçu des instructions d'hygiène buccale accompagnées d'un nettoyage professionnel sans utilization de produits chimiques une fois toutes les 2 semaines pendant 3 mois. L'effet du traitement a été évalué en enregistrant la sousgingivale, les paramètres parodontaux cliniques et la variation quantitative de masse osseuse en analysant par ordinateur la soustraction entre différentes radiographies superposables. La présente étude a révelé que le détartrage sous gingival associé à un contrôle mécanique de la plaque entrînait une diminution du nombre de microorganisms sousgingivaux tells que bâtonnets motiles et spirochètes, et arrêtait la progression de la maladie parodontale. Les agents antimicrobiens associés au détartrage sousgingval réduisaient davantage la microflore sousgingivale et amélioraient signficativement la cicatrisation parodontale initiale entraînant entre autre un gain du niveau d'attache au sondage et de la masse ossuese durant les 12 mois d'observation. Aucune amélioration clinique n'a été notée dand les quadrants non détartrés en sousgingival. Au contraire une tandance à l'aggravation de la maladie parodontale était constatée dans ces quadrants, même lorsqu'ils avaient reçu une application topique individuelle du mélange antimicrobien. Cette étude montre que l'application individuelle et professionnelle d'un mélange de H2O2-NaCl et de NaHCO3 augmente significativement les effets microbiologiques et cliniques de détartrage et du lissage radiculaire. Ces agents et l'application topique d'une thérapie antimicrobeinne semblent prometteurs pour traiter dans l'avenir la maladie parodontale humaine. (French) [ABSTRACT FROM AUTHOR]
AB  - Um bei der Behandlung der Parodontalkrankheit mikrobiologische und klinische Folgen einer subgingival administrierten Lösung von H2O2-NaCl und NaHCO3, bei dann anschliessender subgingivaler Irrigation mit 1%-iger Betadin®-Lösung zu erproben, wurde die hier vorliegende Studie konzipiert. An 20 Erwachsenen mit mässigen bis schweren parodontalen Erkrankungen wurde eine klinische Studie vom "split mouth"- Typ durchgeführt. Alle Probanden erhielten eingangs Instruktionen über die Durchfürung oraler Hygienemassnahmen. Ausserdem wurde der <em>supragingivale</em> Zahnstein aller 4 Quadranten entfernt, <em>Subgingivale</em> Zahnsteinfernung und Wurzelglättung wurde jedoch nur in einer der beiden Gebisshälften vorgenommen. 10 Probanden wurden angewiesen, anstelle einer Zahnpaste, die hier aktuelle chemisch-antimikrobielle Lösung anzuwenden. Darüberhinaus wurde, zusammen mit einer Re-Instruktion über die Durcliführung der oralen Hygiene, die chemisch-antimikrobielle Lösung in 2-wöchentlichen Abständen einmal professionell appliziert. Die verbleibenden 10 Probanden wurden 2 Monate lang in 2-wöchentlichen Abständen in der Durchführung oraler Hygienemassnahmen re-instruiert, jedoch ohne Applikation der chemisch-antimikrobiellen Lösung. Die Bewertung des Behandlungserfolges wurde durch Registrieren der subgingivalen Mikroflora, klinisch-parodontaler Parameter und durch eine datorisierte Subtraktionsanalyse standardisierter Serienröntgenbilder (zur Feststellung von Mengenänderungen des alveolaren Stützknochens) vorgenommen. Die Studie konnete zeigen, dass subgingivale Depuration bei gleichzeitiger mechanischer Plaquekontrolle eine Verringerund der Vorkommenshäufigkeit subgingivaler Mikroorganismen --  einschliesslich der Spirochaeten und der beweglichen Stäbchen - erreichte und weitere Auflösung parodontaler Gewebe aufhalten konnte. Darüberhinaus reduzierten local administrierte antimikrobielle Wirkstoffe - bei gleichzeitiger subgingivaler Zahnsteinentfernung - die subgingivale Mikroflora während der 12-monatlichen Beobachtungszeit noch weiter. Die frühe parodontale Heilung wurde deutlich gefördert. Ausserdem erschien das Niveau des sondierten Attachments sich in günstigerer Lage zu befinden und die röntgenologisch ermittelte Menge alveolaren Stützknochens hatte sich vergrössert. In den Quandranten, in denen kein Zahnstein entfernt wurde, sah man nicht nur keine Anzeichen klinischer Verbesserung, sondern auch die Tendenz zu weitergehender parodontaler Auflösung - such dann, wenn die Probanden selber die antimikrobielle Lösung appliziert hatten. Diese Studie zeigt, dass professionelle und eigene subgingivale Applikation einer Mischung des H2O3-NaCl mit NaHCO3, die mikrobiologische und klinsiche Wirkung parodontaler Zahnsteinentfernung verstärkt. Solche Wirkstoffe, sowie ihrelokale Applikationsform bei der antimikrobiellen Therapie, scheinen für die Behandlung der menschlichen Parodontalkrankheit interessant und vielversprechend zu sein. (German) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical Periodontology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERIODONTICS
KW  - MICROBIOLOGY
KW  - MICROORGANISMS
KW  - BACTERIAL diseases
KW  - PERIODONTAL disease
KW  - ANTI-infective agents
KW  - <em>Probing attachment level</em>
KW  - <em>subgingival microflora</em>
KW  - <em>topical antimicrobial treatment</em>.
N1  - Accession Number: 13500479; Rosling, Bengt G. 1 Slots, Jørgen 1 Webber, Richard L. 1 Christersson, Lars A. 1 Genco, Robert J. 2; Affiliation:  1: Department of Oral Biology and Periodontal Disease Clinical Research Center, School of Dentistry, State University of New York at Buffalo, Buffalo, NY.  2: National Institute of Dental Research and National Institutes of Health, Bethesda, MA, U.S.A.; Source Info: Oct1983, Vol. 10 Issue 5, p487; Subject Term: PERIODONTICS; Subject Term: MICROBIOLOGY; Subject Term: MICROORGANISMS; Subject Term: BACTERIAL diseases; Subject Term: PERIODONTAL disease; Subject Term: ANTI-infective agents; Author-Supplied Keyword: <em>Probing attachment level</em>; Author-Supplied Keyword: <em>subgingival microflora</em>; Author-Supplied Keyword: <em>topical antimicrobial treatment</em>.; Number of Pages: 28p; Document Type: Article
L3  - 10.1111/1600-051X.ep13500479
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Iijima, Masafumi
AU  - Katz, Stephen I.
T1  - Specific Immunologic Tolerance to Dinitrofluorobenzene Following Topical Application of Dinitrothiocyanobenzene: Modulation by Suppressor T Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/10//
VL  - 81
IS  - 4
M3  - Article
SP  - 325
EP  - 330
SN  - 0022202X
AB  - In order to determine the mechanism(s) involved in the induction of immunologic tolerance for contact sensitivity via the topical application of a chemical that sensitizes if given with adjuvant, we utilized the hapten dinitrothiocyanobenzene (DNTB). Specific immunologic tolerance to dinitrofluorobenzene (DNFB) was induced in mice by the topical application of DNTB 7 days before sensitization to DNFB. The tolerance could be abrogated if cyclophosphamide (200 mg/kg) was given 3 days before attempted sensitization. Using passive transfer studies we found that DNTB induced hapten-specific Lyt 1+2- suppressor T cells. These suppressor cells prevented the induction of contact sensitivity but did not affect its expression. Lymphocyte proliferation studies, using haptenated epidermal cells as antigen, indicate that lymph node cells obtained 5 days after DNFB sensitization are far less responsive if the mice have received DNTB epicutaneously 7 days before the DNFB. Binding studies demonstrated that DNTB bound to epidermal cells at least as well as did DNFB. It is postulated that DNTB induction of suppressor cells is related to the physicochemical interaction between the hapten and antigen-presenting cells in skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOLOGIC diseases
KW  - T cells
KW  - DINITROBENZENES
KW  - LYMPHOCYTES
KW  - SUPPRESSOR cells
KW  - EPIDERMIS
N1  - Accession Number: 12519783; Iijima, Masafumi 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Oct83, Vol. 81 Issue 4, p325; Subject Term: IMMUNOLOGIC diseases; Subject Term: T cells; Subject Term: DINITROBENZENES; Subject Term: LYMPHOCYTES; Subject Term: SUPPRESSOR cells; Subject Term: EPIDERMIS; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12519783
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DB  - aph
ER  - 

TY  - JOUR
AU  - Lynch, David H.
AU  - Gurish, Michael F.
AU  - Daynes, Raymond A.
T1  - The Effects of High-Dose UV Exposure on Murine Langerhans Cell Function at Exposed and Unexposed Sites as Assessed Using In Vivo and In Vitro Assays.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/10//
VL  - 81
IS  - 4
M3  - Article
SP  - 336
EP  - 341
SN  - 0022202X
AB  - Exposure of mice to a single large dose of UV radiation leads to a systemic inability of these mice to develop effective contact hypersensitivity (CS) responses to epicutaneously applied dinitrofluorobenzene (DNFB). Although this effect requires time to develop when unirradiated skin sites are used for CS sensitization, it is observed immediately at the site of UV exposure. Unirradiated skin sites on mice exposed to a single large dose of UV radiation 3 days previously were found to contain histochemically detectable ATPase+ cells with normal morphology and in normal densities, and yet CS responses were not induced to DNFB applied to these sites. Epidermal cells (EC) obtained from these skin sites were found to be capable of providing accessory cell (AC) function in in vitro T-cell proliferation assays that was qualitatively similar to EC obtained from unirradiated mice, thus indicating that exposure of mice to a single large dose of UV radiation does not induce a systemic AC dysfunction. Indeed, increased levels of AC activity were obtained in EC prepared from the UV-irradiated skin sites on the third day following UV exposure. This latter effect may be due to an influx of inflammatory cells into the irradiated site in response to the tissue damage caused by the UV radiation. We hypothesize that the inflammatory response induced by the cytodestructive effects of the UV treatment may play a central role in the generation of the systemic suppression of induction of CS responses, perhaps through the induction of acute-phase proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN -- Inflammation
KW  - LANGERHANS cells
KW  - ULTRAVIOLET radiation
KW  - HISTOCHEMISTRY
KW  - T cells
KW  - MICE as laboratory animals
N1  - Accession Number: 12519910; Lynch, David H. 1 Gurish, Michael F. 2 Daynes, Raymond A. 3; Affiliation:  1: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205.  2: Rosenstiel Research Center, Brandeis University, Waltham, Massachusetts 02254.  3: Departments of Obstetrics/Gynecology and Pathology, University of Utah Medical Center, Salt Lake City, Utah, U.S.A.; Source Info: Oct83, Vol. 81 Issue 4, p336; Subject Term: SKIN -- Inflammation; Subject Term: LANGERHANS cells; Subject Term: ULTRAVIOLET radiation; Subject Term: HISTOCHEMISTRY; Subject Term: T cells; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12519910
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rölla, Gunnar
AU  - Amsbaugh, Suzanne M.
AU  - Monell-Torrens, Esteban
AU  - Ellingsen, Jan-Eirik
AU  - Afseth, John
AU  - Ciardi, Joseph E.
AU  - Bowen, William H.
T1  - Effect of topical application of stannous fluoride, stannous chloride and stannous tartrate on rat caries.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1983/10//
VL  - 91
IS  - 5
M3  - Article
SP  - 351
EP  - 355
SN  - 0029845X
AB  - Topical application of 10m<em>M</em> aqueous solutions of stannous fluoride inhibited caries in rats to a higher degree than 20 m<em>M</em> sodium fluoride, although the difference was not statistically significant. Furthermore, stannous fluoride reduced the number of Strep. mutans in plaque significantly; stannous ions have an antibacterial effect. Stannous chloride and stannous tartrate did not reduce caries in the rats, probably because of the low concentrations of available stannous ions in these solutions at low pH. The high concentration of stannous ions in solutions of stannous fluoride is probably partly due to the reduced hydroxide formation resulting from the buffering effect of HF formed at low pH in this solution. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL caries
KW  - TIN
KW  - FLUORIDES
KW  - CHLORIDES
KW  - RATS as laboratory animals
KW  - DENTAL research
KW  - caries inhibition
KW  - metal ions
KW  - trace elements
N1  - Accession Number: 13161550; Rölla, Gunnar 1 Amsbaugh, Suzanne M. 1 Monell-Torrens, Esteban 1 Ellingsen, Jan-Eirik 2 Afseth, John 2 Ciardi, Joseph E. 1 Bowen, William H. 3; Affiliation:  1: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Dental Faculty, University of Oslo, Oslo, Norway.  3: University of Rochester, Medical Center, Rochester, New York, U.S.A.; Source Info: 1983, Vol. 91 Issue 5, p351; Subject Term: DENTAL caries; Subject Term: TIN; Subject Term: FLUORIDES; Subject Term: CHLORIDES; Subject Term: RATS as laboratory animals; Subject Term: DENTAL research; Author-Supplied Keyword: caries inhibition; Author-Supplied Keyword: metal ions; Author-Supplied Keyword: trace elements; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - RISCH, SAMUEL C.
AU  - KALIN, NED H.
AU  - JANOWSKY, DAVID S.
AU  - COHEN, ROBERT M.
AU  - PICKAR, DAVID
AU  - MURPHY, DENNIS L.
T1  - Co-Release of ACTH and β-Endorphin Immunoreactivity in Human Subjects in Response to Central Cholinergic Stimulation.
JO  - Science
JF  - Science
Y1  - 1983/10/07/
VL  - 222
IS  - 4619
M3  - Article
SP  - 77
EP  - 77
SN  - 00368075
N1  - Accession Number: 84671661; RISCH, SAMUEL C. 1; KALIN, NED H. 2; JANOWSKY, DAVID S. 3; COHEN, ROBERT M. 4; PICKAR, DAVID 5; MURPHY, DENNIS L. 6; Affiliations: 1: Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, 92093; 2: Department of Psychiatry, School of Medicine, University of Wisconsin, Madison, Wisconsin, 53141; 3: Department of Psychiatry, School of Medicine, University of California, San Diego; 4: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, 20205; 5: Biological Psychiatry Branch, National Institute of Mental Health; 6: Clinical Neuropharmacology Branch, National Institute of Mental Health; Issue Info: 10/ 7/1983, Vol. 222 Issue 4619, p77; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Sargent, Thomas D.
AU  - Dawid, Igor B.
T1  - Differential Gene Expression in the Gastrula of Xenopus laevis.
JO  - Science
JF  - Science
Y1  - 1983/10/14/
VL  - 222
IS  - 4620
M3  - Article
SP  - 135
EP  - 139
SN  - 00368075
N1  - Accession Number: 85483678; Sargent, Thomas D. 1; Dawid, Igor B. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20205; Issue Info: 10/14/1983, Vol. 222 Issue 4620, p135; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - NEEDLEMAN, SAMUEL W.
AU  - YUASA, YASUHITO
AU  - SRIVASTAVA, SHIV
AU  - AARONSON, STUART A.
T1  - Normal Cells of Patients with High Cancer Risk Syndromes Lack Transforming Activity in the NHI/3T3 Transfection Assay.
JO  - Science
JF  - Science
Y1  - 1983/10/14/
VL  - 222
IS  - 4620
M3  - Article
SP  - 173
EP  - 175
SN  - 00368075
AB  - Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85483702; NEEDLEMAN, SAMUEL W. 1; YUASA, YASUHITO 1; SRIVASTAVA, SHIV 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular, Biology, National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 10/14/1983, Vol. 222 Issue 4620, p173; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WEINSTEIN, JOHN N.
AU  - STELLER, MICHAEL A.
AU  - KEENAN, ANDREW M.
AU  - COVELL, DAVID G.
AU  - KEY, MARC E.
AU  - SIEBER, SUSAN M.
AU  - OLDHAM, ROBERT K.
AU  - HWANG, Kou M.
AU  - PARKER, ROBERT J.
T1  - Monoclonal Antibodies in the Lymphatics: Selective Delivery to Lymph Node Metastases of a Solid Tumor.
JO  - Science
JF  - Science
Y1  - 1983/10/28/
VL  - 222
IS  - 4622
M3  - Article
SP  - 423
EP  - 426
SN  - 00368075
AB  - After subcutaneous injection, monoclonal antibodies directed against a tumor can enter local lymphatic vessels, pass to the draining lymph nodes, and bind to metastases there. Lymphatic delivery of antibody to early metastases is more efficient than intravenous administration, and the lymphatic route can be used to image smaller metastatic deposits. Perhaps more important, the lymphatic route minimizes binding of antibodies to circulating tumor antigens and to cross-reactive antigens present on normal tissues. Antibodies inappropriate for intravenous use because of binding to normal tissues may therefore be useful against lymph node metastases when injected subcutaneously or directly into lymphatic vessels. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671729; WEINSTEIN, JOHN N. 1; STELLER, MICHAEL A. 1; KEENAN, ANDREW M. 2; COVELL, DAVID G. 3; KEY, MARC E. 4; SIEBER, SUSAN M. 5; OLDHAM, ROBERT K. 6; HWANG, Kou M. 6; PARKER, ROBERT J. 5; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Nuclear Medicine, Clinical Center, National Institutes of Health; 3: Laboratory of Theoretical Biology, National Cancer Institute; 4: Cancer Metastasis and Treatment Laboratory, NCI-Frederick Cancer Research Facility, Frederick, Maryland 21701; 5: Office of the Director, Division of Cancer Cause and Prevention, National Cancer Institute; 6: Biological Response Modifiers Program, NCI-Frederick Cancer Research Facility; Issue Info: 10/28/1983, Vol. 222 Issue 4622, p423; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GIALLONGO, AGATA
AU  - APPELLA, ETTORE
AU  - RICCIARDI, ROBERT
AU  - ROVERA, GIOVANNI
AU  - CROCE, CARLO M.
T1  - Identification of the c-myc Oncogene Product in Normal and Malignant B Cells.
JO  - Science
JF  - Science
Y1  - 1983/10/28/
VL  - 222
IS  - 4622
M3  - Article
SP  - 430
EP  - 432
SN  - 00368075
AB  - Antiserum to a synthetic peptide corresponding to the carboxyl-terminus of the human c-myc protein immunoprecipitated a 48,000-dalton protein from a number of normal and malignant human and mouse cells. The size of the protein is consistent with the potential coding region predicted from the c-myc nucleotide sequence, and is the same for malignant cells carrying either a rearranged or an unrearranged c-myc oncogene. Because c-myc transcripts are expressed at higher levels in malignant than in normal B cells, it appears that an increased level of the cmyc protein rather than a change in the gene product is the relevant factor in determining transformation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671732; GIALLONGO, AGATA 1; APPELLA, ETTORE 2; RICCIARDI, ROBERT 3; ROVERA, GIOVANNI 3; CROCE, CARLO M. 3; Affiliations: 1: Wistar Institute, 36th and Spruce Street, Philadelphia, Pennsylvania 19104; 2: Laboratory of Cell Biology, National Cancer Institute Bethesda, Maryland 20205; 3: Wistar Institute and Graduate Group of Molecular Biology, University of Pennsylvania, 36th and Spruce Street, Philadelphia, Pennsylvania 19104; Issue Info: 10/28/1983, Vol. 222 Issue 4622, p430; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Yoakum, George H.
AU  - Korba, Brent E.
AU  - Lechner, John F.
AU  - Tokiwa, Takayoshi
AU  - Gazdar, Adi F.
AU  - Seeley, Todd
AU  - Siegel, Mary
AU  - Leeman, Lawrence
AU  - Autrup, Herman
AU  - Harris, Curtis C.
T1  - High-Frequency Transfection and Cytopathology of the Hepatitis B Virus Core Antigen Gene in Human Cells.
JO  - Science
JF  - Science
Y1  - 1983/10/28/
VL  - 222
IS  - 4622
M3  - Article
SP  - 585
EP  - 389
SN  - 00368075
AB  - A protoplast fusion method was developed to stably transfect human cells with pSV2-derived plasmids at frequencies greater than 10-3. This procedure made it possible to test the biological effect of a hepatitis B virus (HBV) gene independent of the viral structures required for infection. A pSV2gpt+ plasmid constructed to carry a subgenomic fragment of HBV that contained the core antigen gene (HBc gene) was transfected into human cells. A human epithelial cell line was stably transfected with the HBc+ gene by selecting recipient cells for expression of guanine phosphoribosyl transferase expression. With this gpt+/HBc+ cell line it was shown that growth in serum-free medium or treatment with 5'-azacytidine stimulates the production of the HBV core antigen. A hepatocellular carcinoma carrying the entire HBV genome was stimulated to produce the HBc gene product in response to the same factors that stimulated HBcAg production in the gpt+/HBc+ cell line constructed by transfection. The temporal relation between the cytopathologic response and HBc gene expression was similar for both cell types, indicating a primary role for HBc gene expression in the cytopathology of HBV-infected human liver. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671703; Yoakum, George H. 1; Korba, Brent E. 2; Lechner, John F. 1; Tokiwa, Takayoshi 3; Gazdar, Adi F. 4; Seeley, Todd; Siegel, Mary 3; Leeman, Lawrence; Autrup, Herman 1; Harris, Curtis C. 5; Affiliations: 1: Senior staff fellow, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Staff fellow, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory of Human Carcinogenesis, National Cancer Institute; 4: Deputy branch chief, National Cancer Institute-Navy Medical Oncology Branch; 5: Chief, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/28/1983, Vol. 222 Issue 4622, p585; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Schuler, Gerold
AU  - Romani, Nikolaus
AU  - Linert, Johanna
AU  - Shevach, Ethan M.
AU  - Stingl, Georg
T1  - Subsets of Epidermal Langerhans Cells as Defined by Lectin Binding Profiles.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/11//
VL  - 81
IS  - 5
M3  - Article
SP  - 397
EP  - 402
SN  - 0022202X
AB  - In this study we characterize the cell surface glycoconjugate moieties of strain 2 guinea pig epidermal Langerhans cells (LC) in single cell suspension by using a battery of 17 fluorescent lectins. All LC displayed binding sites for concanavalin A, succinylated concanavalin A, <em>Lens culinaris</em> agglutinin, <em>Pisum sativum</em> agglutinin, wheat germ agglutinin, succinylated wheat germ agglutinin, <em>Griffonia simplicifolia</em> agglutinin I, <em>Ricinus communis</em> agglutinin I, <em>Phaseolus vulgaris</em> E agglutinin, and <em>Phaseolus vulgaris</em> L agglutinin, but failed to bind <em>Sophora japonica</em> agglutinin (SJA), <em>Dolichos biflorus</em> agglutinin (DBA), and <em>Ulex europaeus</em> agglutinin I (UEA I). Neuraminidase pretreatment rendered LC reactive for SJA, but not for DBA and UEA I. The binding profiles of certain lectins point to the existence of LC subpopulations in that <em>Griffonia simplicifolia</em> I-B4 isolectin, peanut agglutinin (PNA), <em>Helix pomatia</em> agglutinin, and soybean agglutinin bound to only 80% (range 70-90%) of Ia-positive epidermal cells; binding sites for these lectins on primarily unreactive Ia-positive cells were unmasked when epidermal cells were treated with neuraminidase prior to lectin labeling. Ultrastructural PNA labeling studies revealed that the vast majority of Birbeck granule-containing LC displayed PNA binding sites, whereas indeterminate cells were consistently PNA-negative. Identification of carbohydrate configurations expressed on LC surfaces by lectin binding may provide a clue for the elucidation of the mechanisms of established LC functions and possibly the discovery of as yet unknown properties of this cell type. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - LECTINS
KW  - RESEARCH
KW  - GLYCOCONJUGATES
KW  - NEURAMINIDASE
KW  - AGGLUTININS
KW  - CARBOHYDRATES in the body
N1  - Accession Number: 12521995; Schuler, Gerold 1 Romani, Nikolaus 1 Linert, Johanna 1 Shevach, Ethan M. 2 Stingl, Georg 3; Affiliation:  1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.  2: NIAID, National Institutes of Health, Bethesda, Maryland, U.S.A..  3: Department of Dermatology I, University of Vienna, Vienna, Austria.; Source Info: Nov83, Vol. 81 Issue 5, p397; Subject Term: LANGERHANS cells; Subject Term: LECTINS; Subject Term: RESEARCH; Subject Term: GLYCOCONJUGATES; Subject Term: NEURAMINIDASE; Subject Term: AGGLUTININS; Subject Term: CARBOHYDRATES in the body; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12521995
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Katz, Stephen I.
T1  - Suction Blister Apparatus.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/11//
VL  - 81
IS  - 5
M3  - Letter
SP  - 467
EP  - 467
SN  - 0022202X
AB  - Presents a letter to the editor stating the willingness to share the blueprints of a Suction Blister Apparatus.
KW  - LETTERS to the editor
KW  - BLUEPRINTS
N1  - Accession Number: 12522678; Katz, Stephen I. 1; Affiliation:  1: Building 10, Room 12N238, National Cancer Institute, Bethesda, Maryland 20205.; Source Info: Nov83, Vol. 81 Issue 5, p467; Subject Term: LETTERS to the editor; Subject Term: BLUEPRINTS; Number of Pages: 1/6p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12522678
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Hagen, Jan L.
AU  - Mannino, Fortune V.
AU  - McQuaide, Sharon
AU  - Istridis, Demetrius
AU  - Barnes, John
AU  - Crow, Gary A.
AU  - Shepard, Fatty
AU  - Kloeppel, Dariene A.
T1  - letters.
JO  - Social Work
JF  - Social Work
Y1  - 1983/11//Nov/Dec83
VL  - 28
IS  - 6
M3  - Letter
SP  - 491
EP  - 495
PB  - Oxford University Press / USA
SN  - 00378046
AB  - Presents several letters to the editor. Information regarding the social values; Discussion on the issue of manuscripts of social work; Insight into the sleep therapy.
KW  - LETTERS to the editor
KW  - SOCIAL values
KW  - MANUSCRIPTS
KW  - SLEEP therapy
KW  - HUMAN services
KW  - SOCIAL services
N1  - Accession Number: 5268816; Hagen, Jan L. 1 Mannino, Fortune V. 2 McQuaide, Sharon 3 Istridis, Demetrius 4 Barnes, John 5 Crow, Gary A. 6 Shepard, Fatty 7 Kloeppel, Dariene A. 8; Affiliation:  1: School of Social Work, University of Minnesota, Minneapolis.  2: Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Mental Health Study Center, Adelphi, Maryland.  3: William W. Backus Hospital Norwich, Connecticut.  4: Graduate School of Social Work, Boston College, Chestnut Hill, Massachusetts.  5: School of Social Work, University of Windsor, Windsor, Ontario, Canada.  6: Logan-Champaign Guidance Clinic, Urbana and Bellefontaine, Ohio.  7: Social Service, Beth Israel Hospital Boston, Massachusetts.  8: South Fulton Hospital, East Point, Georgia.; Source Info: Nov/Dec83, Vol. 28 Issue 6, p491; Subject Term: LETTERS to the editor; Subject Term: SOCIAL values; Subject Term: MANUSCRIPTS; Subject Term: SLEEP therapy; Subject Term: HUMAN services; Subject Term: SOCIAL services; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 5p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - VALLERA, DANIEL A.
AU  - ASH, ROBERT C.
AU  - ZANJANI, ESMAIL D.
AU  - KERSEY, JOHN H.
AU  - LEBIEN, TUCKER W.
AU  - BEVERLEY, PETER C. L.
AU  - NEVILLE JR., DAVID M.
AU  - YOULE, RICHARD J.
T1  - Anti-T-Cell Reagents for Human Bone Marrow Transplantation: Ricin Linked to Three Monoclonal Antibodies.
JO  - Science
JF  - Science
Y1  - 1983/11/04/
VL  - 222
IS  - 4623
M3  - Article
SP  - 512
EP  - 515
SN  - 00368075
AB  - Three new reagents that react against human T cells were synthesized by covalently linking the toxin ricin to monoclonal antibodies recognizing differentiation antigens on the surface of T lymphocytes. Each of these immunotoxins selectively inhibited T-cell proliferation when the cells were incubated in the presence of lactose. Multipotent human stem cells were inhibited only at much higher concentrations. Mixtures of all three immunotoxins were more effective than any one alone. These reagents have the potential for preventing graft-versus-host disease in man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671775; VALLERA, DANIEL A. 1; ASH, ROBERT C. 2; ZANJANI, ESMAIL D. 2; KERSEY, JOHN H. 3; LEBIEN, TUCKER W. 4; BEVERLEY, PETER C. L. 5; NEVILLE JR., DAVID M. 6; YOULE, RICHARD J. 6; Affiliations: 1: Department of Therapeutic Radiology and Laboratory MedicinelPathology, University of Minnesota, Minneapolis 55455; 2: Veterans Administration, Medical Center, Minneapolis, Minnesota 55406; 3: Department of Laboratory Medicinel Pathology and Pediatrics, University of Minnesota; 4: Department of Laboratory Medicine! Pathology, University of Minnesota; 5: ICRF Human Tumour Immunology Group, University College Hospital Medical School, London, England; 6: Section on Biophysical Chemistry, Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 11/ 4/1983, Vol. 222 Issue 4623, p512; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kempner, E. S.
AU  - Miller, J. H.
T1  - Radiation Inactivation of Glutamate Dehydrogenase Hexamer: Lack of Energy Transfer Between Subunits.
JO  - Science
JF  - Science
Y1  - 1983/11/11/
VL  - 222
IS  - 4624
M3  - Article
SP  - 586
EP  - 589
SN  - 00368075
AB  - The effects of ionizing radiation on glutamate dehydrogenase and on fluorescein isothiocyanate-tagged glutamate dehydrogenase were analyzed by target theory. Enzymatic activity, fluorescence, and the survival of the 56,000-dalton monomer subunit were determined on frozen samples irradiated at - 135°C and on lyophilized samples irradiated at either -135°C or +30°C. The effects oftemperature were the samefor all three parameters. Enzymatic activity was lost after small doses of high-energy electrons, whereas fluorescence and monomer subunits survived much larger doses of radiation. Target analysis revealed that the functional unit size for enzymatic activity was the hexamer, confirming both the earlier radiation study and conventional biochemical analyses. Target sizes obtainedfromfluorescence and subunit structure measurements were close to that of the monomer. These results indicate that the primary ionization caused by electron bombardment results in damage to a single polypeptide strand and that there is no massive transfer of radiation energy to other units in the hexamer. The large target size observed for enzymatic activity appears to be a structural requirement for the simultaneous presence ofsix intact subunits rather than the result of the spread ofenergy from the initial site to adjacent chains with consequent damage to other subunits. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671790; Kempner, E. S. 1; Miller, J. H. 1; Affiliations: 1: National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/11/1983, Vol. 222 Issue 4624, p586; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
AU  - Rosenberg, Martin
AU  - Chepelinsky, Ana B.
AU  - McKenney, Keith
T1  - Studying Promoters and Terminators by Gene Fusion.
JO  - Science
JF  - Science
Y1  - 1983/11/18/
VL  - 222
IS  - 4625
M3  - Article
SP  - 734
EP  - 739
SN  - 00368075
N1  - Accession Number: 84671830; Rosenberg, Martin 1,2; Chepelinsky, Ana B. 3,4; McKenney, Keith 5; Affiliations: 1: Staff, Laboratory'of Biochemistry, National Cancer Institute, Bethesda, Maryland 20205; 2: Director, Department of Molecular Genetics, Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101; 3: Laboratory of Biochemistry, National Cancer Institute; 4: Department of Molecular and Developmental Biology, National Eye Institute, Bethesda 20205; 5: Laboratory of Molecular Biology, Medical Research Council Centre, University Medical School, Cambridge CB2 2QH, England; Issue Info: 11/18/1983, Vol. 222 Issue 4625, p734; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rosenthal, Nadia
AU  - Kress, Michel
AU  - Gruss, Peter
AU  - Khoury, George
T1  - BK Viral Enhancer Element and a Human Cellular Homolog.
JO  - Science
JF  - Science
Y1  - 1983/11/18/
VL  - 222
IS  - 4625
M3  - Article
SP  - 749
EP  - 755
SN  - 00368075
N1  - Accession Number: 84671832; Rosenthal, Nadia 1; Kress, Michel 1; Gruss, Peter 1; Khoury, George 1; Affiliations: 1: Staff members, Laboratory of Molecular Virology, National Cancer Institute, Building 41, Suite 200, Bethesda, Maryland 20205; Issue Info: 11/18/1983, Vol. 222 Issue 4625, p749; Number of Pages: 7p; Document Type: Article
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TY  - JOUR
AU  - Nirenberg, M.
AU  - Wilson, S.
AU  - Higashida, H.
AU  - Rotter, A.
AU  - Krueger, K.
AU  - Busis, N.
AU  - Ray, R.
AU  - Kenimer, J. G.
AU  - Adler, M.
T1  - Modulation of Synapse Formation by Cyclic Adenosine Monophosphate.
JO  - Science
JF  - Science
Y1  - 1983/11/18/
VL  - 222
IS  - 4625
M3  - Article
SP  - 794
EP  - 799
SN  - 00368075
N1  - Accession Number: 84671839; Nirenberg, M. 1; Wilson, S. 1; Higashida, H. 1; Rotter, A. 1; Krueger, K. 1; Busis, N. 1; Ray, R. 1; Kenimer, J. G. 1; Adler, M. 1; Affiliations: 1: Members, Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 36, Room IC-06, Bethesda, Maryland 20205; Issue Info: 11/18/1983, Vol. 222 Issue 4625, p794; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FREED, WILLIAM J:
AU  - Ko, GRANT N.
AU  - NIEHOFF, DEBRA L.
AU  - KUHAR, MICHAEL J.
AU  - HOFFER, BARRY J.
AU  - OLSON, LARS
AU  - CANNON-SPOOR, H. ELEANOR
AU  - MORIHISA, JOHN M.
AU  - WYATT, RICHARD JED
T1  - Normalization of Spiroperidol Binding in the Denervated Rat Striatum by Homologous Grafts of Substantia Nigra.
JO  - Science
JF  - Science
Y1  - 1983/11/25/
VL  - 222
IS  - 4626
M3  - Article
SP  - 937
EP  - 939
SN  - 00368075
AB  - Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantia nigra. The authors report that this effect of transplantation is specific to grafts of substantia nigra. They also report that, in conjunction with the decrease in motor asymmetry, these grafts cause postsynaptic dopaminergic binding sites to return to normal density as measured by tritiated spiroperidol autoradiography. Thus, in animals with brain lesions, grafts of substantia nigra produce a long-term alteration in the functional status ofhost brain cell receptors that is associated with a reduction in the behavioral deficit. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671882; FREED, WILLIAM J: 1; Ko, GRANT N. 1; NIEHOFF, DEBRA L. 2; KUHAR, MICHAEL J. 2; HOFFER, BARRY J. 3; OLSON, LARS 4; CANNON-SPOOR, H. ELEANOR 5; MORIHISA, JOHN M. 5; WYATT, RICHARD JED 5; Affiliations: 1: Preclinical Neurosciences Section, Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 3: Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262; 4: Department of Histology, Karolinska Institute, Stockholm, Sweden; 5: Preclinical Neurosciences Section, Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital; Issue Info: 11/25/1983, Vol. 222 Issue 4626, p937; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Zahn-Waxler, Carolyn
AU  - Friedman, Sarah L.
AU  - Cummings, E. Mark
T1  - Children's Emotions and Behaviors in Response to Infants' Cries.
JO  - Child Development
JF  - Child Development
Y1  - 1983/12//
VL  - 54
IS  - 6
M3  - Article
SP  - 1522
EP  - 1528
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12418532; Zahn-Waxler, Carolyn 1 Friedman, Sarah L. 1 Cummings, E. Mark 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Dec1983, Vol. 54 Issue 6, p1522; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1467-8624.ep12418532
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Horowitz, Herschel S.
T1  - Evaluation of the effect of interexaminer reliability in clinical trials of dental caries prevention.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1983/12//
VL  - 11
IS  - 6
M3  - Article
SP  - 384
EP  - 385
SN  - 03015661
AB  - Data from a 3-yr clinical trial were used to assess reliability of two dentists who, without standardizing techniques, independently examined 286 continuous participants. Only 13.1 of 128 tooth surfaces (third molars excluded) showed a change in caries status during the trial by one or both examiners' findings. Although there was poor agreement between the examiners (46.5%) on these changes, they agreed very closely on measuring the cariostatic effects in the various treatment groups because the disagreements were random and were similar among groups. [ABSTRACT FROM AUTHOR]
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KW  - DENTAL caries
KW  - EPIDEMIOLOGY
KW  - CLINICAL trials
KW  - DENTISTS
KW  - TEETH -- Care & hygiene
KW  - DENTAL care
KW  - dental caries
KW  - epidemiology
KW  - oral
KW  - reliability.
N1  - Accession Number: 12019241; Horowitz, Herschel S. 1; Affiliation:  1: National Caries Program, National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Dec1983, Vol. 11 Issue 6, p384; Subject Term: DENTAL caries; Subject Term: EPIDEMIOLOGY; Subject Term: CLINICAL trials; Subject Term: DENTISTS; Subject Term: TEETH -- Care & hygiene; Subject Term: DENTAL care; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: oral; Author-Supplied Keyword: reliability.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1600-0528.ep12019241
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Murthy, Adavi S. N.
AU  - Flavin, Martin
T1  - Microtubule assembly using the microtubule-associated protein MAP-2 prepared in defined stated of phosphorylation with protein kinase and phosphatase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1983/12//12/1/83
VL  - 137
IS  - 1/2
M3  - Article
SP  - 37
EP  - 46
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A microtubule-associated protein (the 270-kDa MAP-2) was prepared in two defined stats of phosphorylation by (a) phosphorylation by associated kinase to the extent of ll–14 mol/mol, and (b) removal of 70–80% of this phosphate with a protein phosphatase purified from brain. The newly introduced phosphate was in addition to about 10 mol/mol already present in MAP-2 as isolated; these phosphates were not appreciably released by the phosphatase and did not exchange with ATP. In microtubules assembled with phosphorylated 24 mol/mol) MAP-2 the assembly rate was decreased, microtubule length and critical concentration for assembly were unaffected, and rates of loss of subunits were increased from both microtubule ends. Phosphorylation also reduced the binding of MAP-2 to taxol-stabilized microtubules. These changes were unequivocally due to phosphorylation, sin phosphatase treatment reversed all of them. The brain phosphatase used in the experiments was purified 3000-fold towards histone, but only 100-fold towards MAP-2, suggesting brain may contain another enzyme more specific for MAP+2. Calcineurin, however, had only a low activity for MAP-2. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - BONE products
KW  - PHOSPHOPROTEIN phosphatases
KW  - CELL organelles
KW  - MICROTUBULES
KW  - PROTEIN kinases
KW  - PHOSPHATASES
N1  - Accession Number: 13867164; Murthy, Adavi S. N. 1 Flavin, Martin 1; Affiliation:  1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 12/1/83, Vol. 137 Issue 1/2, p37; Subject Term: RESEARCH; Subject Term: BONE products; Subject Term: PHOSPHOPROTEIN phosphatases; Subject Term: CELL organelles; Subject Term: MICROTUBULES; Subject Term: PROTEIN kinases; Subject Term: PHOSPHATASES; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hou, De-Yan
AU  - Hoch, Hans
AU  - Johnston, Gerald
AU  - Tsou, K.
AU  - Farkas, Raymond
AU  - Miller, Elizabeth
T1  - Stability of In-Bleomycin in vivo -Properties compared with Co-bleomycin.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1983/12//
VL  - 8
IS  - 12
M3  - Article
SP  - 535
EP  - 540
SN  - 03406997
N1  - Accession Number: 71154011; Hou, De-Yan 1 Hoch, Hans 1 Johnston, Gerald 1 Tsou, K. 2 Farkas, Raymond 1 Miller, Elizabeth 2; Affiliation:  1: Department of Nuclear Medicine, National Institutes of Health, Building 10, room 1C401, ACRF 20205 Bethesda USA  2: Harrison Department of Surgical Research, University of Pennsylvania, 19104 Philadelphia USA; Source Info: Dec1983, Vol. 8 Issue 12, p535; Number of Pages: 6p; Document Type: Article
L3  - 10.1007/BF00251616
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ansel, John C.
AU  - Luger, Thomas A.
AU  - Green, Ira
T1  - The Effect of In Vitro and In Vivo UV Irradiation on the Production of ETAF Activity by Human and Murine Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1983/12//
VL  - 81
IS  - 6
M3  - Article
SP  - 519
EP  - 523
SN  - 0022202X
AB  - Cultured epidermal cells and keratinocytes produce a potent hormone-like factor called epidermal cell-derived thymocyte-activating factor (ETAF). ETAF appears to be similar if not identical to a monocyte-derived lymphokine, known as interleukin 1 (IL-1). These two cytokines are able to amplify a diverse number of proliferative and inflammatory processes. Several recent investigations have suggested that UV-induced immunosuppression may be due in part to the inhibition of IL-1/ETAF production by monocytes and keratinocytes, respectively. We therefore decided to directly study the effects of various doses of in vitro and in vivo UV radiation (UVR) on the production of ETAF by normal murine epidermal cells and a murine (Pam 212) and a human (SCC) keratinocyte cell line. Our results surprisingly demonstrated an increase in both the extracellular and the intracellular ETAF activity of the murine epidermal, Pam 212, and SCC after sublethal amounts of in vitro UVR. Likewise, increased ETAF activity of murine epidermal cells was detected after sublethal doses of in vivo UVR. The UV-induced ETAF activity was cycloheximide-sensitive, suggesting that de novo synthesis of ETAF rather than cell membrane leakage was responsible for the increased ETAF activity. The fact that UV irradiation can increase ETAF activity by keratinocytes could have important local and systemic consequences for the host and may provide an efficient, contaminant-free method for generating ETAF activity for further biochemical and immunologic studies. [ABSTRACT FROM AUTHOR]
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KW  - CELLS
KW  - KERATINOCYTES
KW  - CELL culture
KW  - IMMUNE response -- Regulation
KW  - CYTOKINES
KW  - CELLULAR immunity
N1  - Accession Number: 12522862; Ansel, John C. 1 Luger, Thomas A. 2 Green, Ira 1; Affiliation:  1: Laboratory of Immunology, National institute of Allergy and infectious Diseases, National institutes of Health, Bethesda, Maryland, U.S.A.  2: 2nd Department of Dermatology, University of Vienna, Vienna, Austria.; Source Info: Dec83, Vol. 81 Issue 6, p519; Subject Term: CELLS; Subject Term: KERATINOCYTES; Subject Term: CELL culture; Subject Term: IMMUNE response -- Regulation; Subject Term: CYTOKINES; Subject Term: CELLULAR immunity; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12522862
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Qwarnstrom, E.E.
AU  - Omnell, K.-A.
AU  - Hand, A.R.
T1  - A morphologic study of the recovery of the rat submandibular gland after retrograde infusion.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1983/12//
VL  - 12
IS  - 6
M3  - Article
SP  - 417
EP  - 429
SN  - 03009777
AB  - The recovery of the rat submandibular gland after retrograde infusion of water-soluble radiographic contact medium was studied using an experimental model. During continuous monitoring of the developing intraglandular pressure, the glands were subjected to ducta and slight parenchymal filling or heavy parenchymal filling with the medium. The animals were killed after varying recovery periods, and the tissue was prepared for light and electron microscopic examination. Dilation of the ductal lumina, induced during ductal and slight parenchymal filling, was successively reduced and, generally, the parenchyma had a normal appearance at 30 h. In glands subjected to heavy parenchymal filling, the changes in the intralobular ducts were more pronounced and were also seen at later times after infusion. Alterations in the acini, comprising fusion of secretory granules, vacuole formation and dilation of the acinar lumina and intercellular canaliculi, were observed. At later times, atrophy of the parenchymal cells occurred together with an apparent proliferation of the connective-tissue stroma, as well as an increase in the number of small blood vessels. An inflammatory cell-infiltrate was seen in both groups of animals, but was most prominent in glands subjected to heavy parenchymal filling.  The infiltrate, comprised primarily of macrophages and polymorphonuclear leukocytes, reached a peak at 20 h after infusion. At later times, mast cells and occasional eosinophils were seen. The observed alterations and the pattern of recovery are most likely due to the induced intraglandular pressure and the following inflammatory reaction. It is also possible that the changes, to some extent, are influenced by the presence of the contrast medium in the tissue. [ABSTRACT FROM AUTHOR]
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KW  - SUBMANDIBULAR gland
KW  - CONTRAST media (Diagnostic imaging)
KW  - MORPHOLOGY
KW  - RATS
N1  - Accession Number: 11393058; Qwarnstrom, E.E. 1 Omnell, K.-A. 1 Hand, A.R. 1; Affiliation:  1: Laboratory of Oral Biology and Physiology, National Institute of Dental Research, National Institutes of Health, USA; Source Info: Dec83, Vol. 12 Issue 6, p417; Subject Term: SUBMANDIBULAR gland; Subject Term: CONTRAST media (Diagnostic imaging); Subject Term: MORPHOLOGY; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1600-0714.ep11393058
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Magrath, Ian
AU  - Erikson, Jan
AU  - Whang-Peng, Jacqueline
AU  - Sieverts, Hauke
AU  - Armstrong, Gary
AU  - Benjamin, David
AU  - Triche, Timothy
AU  - Alabaster, Oliver
AU  - Croce, Carlo M.
T1  - Synthesis of Kappa Light Chains by Cell Lines Containing an 8;22 Chromosomal Translocation Derived from a Male Homosexual with Burkitt's Lymphoma.
JO  - Science
JF  - Science
Y1  - 1983/12/09/
VL  - 222
IS  - 4628
M3  - Article
SP  - 1094
EP  - 1098
SN  - 00368075
AB  - Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the κ type, in contrast to the usual concordance between a translocation involving chromosome 22 and λ chain synthesis. Both κ genes and one λ gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence ofimmunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm ofchromosome 8 and a chromosome bearing an immunoglobulin gene, alteration ofcellular myc expression may occur regardless of the immunoglobulin gene that is expressed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671938; Magrath, Ian 1; Erikson, Jan 2; Whang-Peng, Jacqueline 3; Sieverts, Hauke 1; Armstrong, Gary 4; Benjamin, David 1; Triche, Timothy 5; Alabaster, Oliver 6; Croce, Carlo M. 2; Affiliations: 1: Pediatric Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 3: Medicine Branch, Division of Cancer Treatment, National Cancer Institute; 4: Division of Virology, Office of Biologics, National Center of Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland 20205; 5: Laboratory of Pathology, National Cancer Institute; 6: Division of Hematology/Oncology, George Washington University, Washington, D.C. 20037; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1094; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - WHITNALL, MARK H.
AU  - GAINER, HAROLD
AU  - COX, BRIAN M.
AU  - MOLINEAUX, CHRISTOPHER J.
T1  - Dynorphin-A-(1-8) Is Contained Within Vasopressin Neurosecretory Vesicles in Rat Pituitary.
JO  - Science
JF  - Science
Y1  - 1983/12/09/
VL  - 222
IS  - 4628
M3  - Article
SP  - 1137
EP  - 1139
SN  - 00368075
AB  - Dynorphin-A-(1-8), an opioid peptide widely distributed in the rat central nervous system, is present in vasopressin-containing neurosecretory cells terminating in the neural lobe of the pituitary. Electron microscopic immunocytochemistry reveals that dynorphin-A-(1-8) is contained within the same neurosecretory vesicles as vasopressin and vasopressin-associated neurophysin in the neural lobe of the rat. The results indicate that dynorphin may be released in the pituitary concomitantly with vasopressin during the antidiuretic response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671964; WHITNALL, MARK H. 1; GAINER, HAROLD 1; COX, BRIAN M. 2; MOLINEAUX, CHRISTOPHER J. 2; Affiliations: 1: Laboratory of Neurochemistry and Neuroimmunology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1137; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - DONIGER, J.
AU  - Di PAOLO, J. A.
AU  - POPESCU, N. C.
T1  - Transformation of Bloom's Syndrome Fibroblasts by DNA Transfection.
JO  - Science
JF  - Science
Y1  - 1983/12/09/
VL  - 222
IS  - 4628
M3  - Article
SP  - 1144
EP  - 1146
SN  - 00368075
AB  - Nonmalignant diploid humanfibroblast cells (GM3498B) derivedfrom a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude micecharacteristics ofneoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671967; DONIGER, J. 1; Di PAOLO, J. A. 1; POPESCU, N. C. 1; Affiliations: 1: Laboratory of Biology, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1144; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - BARE, KEITH
AU  - CLARK, JEFF
AU  - FINE, ROBERT
AU  - HOOVER, CAROL
AU  - JACQUEZ, JOHN A.
AU  - KONIG, MONIKA
AU  - LANDER, MARILYN
AU  - MCKINLEY, PAT
AU  - O'NEILL, VERONICA
AU  - SCHIFFMANN, GENEVIEVE
T1  - The AAAS and Human Rights.
JO  - Science
JF  - Science
Y1  - 1983/12/16/
VL  - 222
IS  - 4629
M3  - Article
SP  - 1189
EP  - 1189
SN  - 00368075
N1  - Accession Number: 84671969; BARE, KEITH 1; CLARK, JEFF 1; FINE, ROBERT 1; HOOVER, CAROL 1; JACQUEZ, JOHN A. 1; KONIG, MONIKA 1; LANDER, MARILYN 1; MCKINLEY, PAT 1; O'NEILL, VERONICA 1; SCHIFFMANN, GENEVIEVE 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; 2: Medical Scientists Committee, National Institutes of Health, affiliated with Amnesty International; Issue Info: 12/16/1983, Vol. 222 Issue 4629, preceding p1189; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SHIMOMURA, KYOICHI
AU  - MULLINIX, MARY G.
AU  - KAKUNAGA, TAKEO
AU  - FUJIKI, HIROTA
AU  - SUGIMURA, TAKASHI
T1  - Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxn, a Tumor Promoter.
JO  - Science
JF  - Science
Y1  - 1983/12/16/
VL  - 222
IS  - 4629
M3  - Article
SP  - 1242
EP  - 1244
SN  - 00368075
AB  - Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding ofphorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84671997; SHIMOMURA, KYOICHI 1; MULLINIX, MARY G. 1; KAKUNAGA, TAKEO 1; FUJIKI, HIROTA 2; SUGIMURA, TAKASHI 2; Affiliations: 1: Cell Genetics Section, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: National Cancer Center Research Institute, Tokyo, Japan; Issue Info: 12/16/1983, Vol. 222 Issue 4629, p1242; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - HEALY, DAVID L.
AU  - HODGEN, GARY D.
AU  - SCHULTE, HEINRICH M.
AU  - CHROUSOS, GEORGE P.
AU  - LORIAUX, D. LYNN
AU  - HALL, NICHOLAS R.
AU  - GOLDSTEIN, ALLAN L.
T1  - The Thymus-Adrenal Connection: Thymosin Has Corticotropin-Releasing Activity in Primates.
JO  - Science
JF  - Science
Y1  - 1983/12/23/
VL  - 222
IS  - 4630
M3  - Article
SP  - 1353
EP  - 1355
SN  - 00368075
AB  - Endotoxin-free thymosin fraction 5 elevated corticotropin, β-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides ofthymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy ofjuvenile macaques was associated with decreases in plasma cortisol, corticotropin, and β-Iendorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84672038; HEALY, DAVID L. 1; HODGEN, GARY D. 1; SCHULTE, HEINRICH M. 2; CHROUSOS, GEORGE P. 2; LORIAUX, D. LYNN 2; HALL, NICHOLAS R. 3; GOLDSTEIN, ALLAN L. 3; Affiliations: 1: Pregnancy Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Developmental Endocrinology Branch, National Institute of Child Health and Human Development; 3: Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037; Issue Info: 12/23/1983, Vol. 222 Issue 4630, p1353; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - Gen
ID  - 9999-06089-000
AN  - 9999-06089-000
AU  - Schroeder, David H.
AU  - Costa, Paul T. Jr.
T1  - Life Event List
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1984///
AD  - Costa, Paul T. Jr., Baltimore City Hospitals, Gerontology Research Center, Section on Stress and Coping, Baltimore, Maryland, United States, 21224
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: Unknown. Test Items: Yes
N1  - Accession Number: 9999-06089-000. Partial author list: First Author & Affiliation: Schroeder, David H.; National Institutes of Health, National Institute on Aging, Gerontology Research Center, United States. Release Date: 20111010. Correction Date: 20160808. Instrument Type: Checklist. Test Format: Participants mark each event on the Life Event List that they had experienced during the past year, which was divided into two 6-month periods. For each event marked, they also rate the degree of distress that they experienced on a scale of 0-100 points. The overall event score consists of the total number of events marked for the 12-month period.. Language: English. Constructs: Life Event Stress; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Life Event List is to assess stressful life events.
AB  - Description: The Life Event List (Schroeder & Costa, Jr., 1984) was developed to measure stressful life events. This measure was constructed in the course of a study investigating the hypothesis that the reported relationship between life event stress and physical illness is primarily a function of criterion and other content contamination in the stress measure. The Life Event List consists of 87 items and was designed to constitute a reasonably comprehensive, representative counterpart to the lists used in the literature. The first 42 events in the list were taken from the Holmes-Rahe (1967) Schedule of Recent Experience. To these items, 45 events that were drawn from lists used by Paykel et al. (1971); Myers, Lindenthal, and Pepper (1971); B. S. Dohrenwend, Krasnoff, Askenasy, and B. P. Dohrenwend (1978); and Johnson and Sarason (1979) and other items judged to be appropriate to a broad adult population were added. Participants (N = 386) were asked to mark each event on the list that they had experienced during the past year, which was divided into two 6-month periods. For each event marked, they also rated the degree of distress that they experienced on a scale of 0-100 points. The overall event score consisted of the total number of events marked for the 12-month period. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Influence of Stress
KW  - Life Event List
KW  - Live Event Stress
KW  - Physical Illness
KW  - Test Development
U5  - Life Event List [Test Development]Influence of life event stress on physical illness: Substantive effects or methodological flaws?. (AN: 1984-23643-001 from PsycINFO) Schroeder, David H.; Costa, Paul T.; Apr, 1984. Source: Journal of Personality and Social Psychology. 46(4), American Psychological Association, US; Apr, 1984; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Location: US; Sample: Adults Ranging in Age from the Early 20s to the 90s Keywords: Influence of Stress; Life Event List; Live Event Stress; Physical Illness; Test Development; Subjects: Experiences (Events); Measurement; Physical Disorders; Psychophysiology; Stress Reactions; Test Construction;
DO  - 10.1037/t06089-000
L3  - Partial; Full text; 999906089_partial_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-08111-000
AN  - 9999-08111-000
AU  - McCrae, Robert R.
T1  - Coping Mechanism Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1984///
AD  - McCrae, Robert R., Gerontology Research Center, Section on Stress and Coping, Baltimore City Hospitals, Baltimore, Maryland, United States, 21224
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-08111-000. Partial author list: First Author & Affiliation: McCrae, Robert R.; National Institutes of Health, National Institute on Aging, Gerontology Research Center, Maryland, United States. Release Date: 20120109. Correction Date: 20151109. Instrument Type: Rating Scale. Language: English. Constructs: Coping Mechanisms; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Coping Questionnaire is to measure a broad range of coping mechanisms utilized as a result of exposure to a stressful life event categorized as either a loss, a threat, or a challenge.
AB  - Description: The Coping Mechanism Questionnaire (McCrae, 1984) was developed in an assessing the influence of losses, threats, and challenges on the choice of coping mechanisms. To develop items for the study, men and women responded to 118 items that described ways of coping with stressors and to indicated which of these they had employed at any time during the course of the stressful event. The first 68 items were taken from Ways of Coping (Folkman & Lazarus, 1980); the last 50 were specifically written to cover the major mechanisms identified in a review of the literature. An examination of both item content and intercorrelations showed that most of the information in the 118 items could be represented by a smaller number of scales. Thirty-four factors had eigenvalues greater than 1, and, after varimax rotation, 28 were used as guides to the creation of scales. Since many items had loadings on several scales, the final scale composition was also guided by rational considerations. The reliability of several scales is low to moderate (alphas ranging from .39 to .83). (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Coping Mechanism Scale
KW  - Test Development
KW  - Coping Responses
KW  - Stressful Events
KW  - Faith
KW  - Fatalism
KW  - Expression of Feelings
U5  - Coping Mechanism Scale [Test Development]Situational determinants of coping responses: Loss, threat, and challenge. (AN: 1984-23131-001 from PsycINFO) McCrae, Robert R.; Apr, 1984. Source: Journal of Personality and Social Psychology. 46(4), American Psychological Association, US; Apr, 1984; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Location: United States; Sample: Baltimore Longitudinal Study of Aging Participants (Ages 21-91) Keywords: Coping Mechanism Scale; Test Development; Coping Responses; Stressful Events; Faith; Fatalism; Expression of Feelings; Subjects: Coping Behavior; Rating Scales; Test Construction;
DO  - 10.1037/t08111-000
L3  - Full; Full text; 999908111_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-13546-000
AN  - 9999-13546-000
AU  - Hamilton, Jean A.
AU  - Haier, Richard J.
AU  - Buchsbaum, Monte S.
T1  - Boredom Coping Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1984///
AD  - Hamilton, Jean A., CRB/DERP/NIMH, Center for Studies of Affective Disorders, Biology of Depression Research Unit, Room 10-C-26, Parklawn Building, 5600 Fishers Lane, Rockville, Maryland, United States, 20857
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-13546-000. Acronyms: BC. Partial author list: First Author & Affiliation: Hamilton, Jean A.; National Institute of Mental Health, Clinical Neuropharmacology Branch, Bethesda, Maryland, United States. Release Date: 20120813. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: The Boredom Coping Scale is a forced-choice scale; the scores range from 0-10, with high scores suggesting more capacity to cope with boredom and, perhaps, less boredom.. Language: English. Constructs: Boredom Coping; Classification: Personality (7200). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Boredom Coping Scale is to assess the disposition to restructure one’s perceptions and participation in potentially boring activities so as to decrease boredom.
AB  - Description: The Boredom Coping Scale (BC; Hamilton, Haier, & Buchsbaum, 1984) was developed to assess the disposition to restructure one’s perceptions and participation in potentially boring activities so as to decrease boredom. The 10 items for this scale were adapted, in part, from items on Zuckerman’s (1979) subscale called 'Boredom Susceptibility' (ZBS) and the Singer and Antrobus (1970) Imaginal Processes Inventory. The BC is a forced-choice scale with statements pertaining to different contexts or situations; the scores range from 0-10, with high scores suggesting more capacity to cope with boredom and, perhaps, less boredom. In a sample of high school students, Cronbach's coefficient alpha for the BC was .67. Test-retest reliability, based on a 1- to 3-week interval for nursing students, was .64. Construct validity was established by comparison with previously-validated personality tests, real-life measures, and laboratory measures of attention. Boredom coping is associated with a higher percent of time actually spent alone, high continuous performance task measures of attentional capacity, and low Minnesota Multiphasic Personality Inventory and Research Diagnostic Criteria indices of psychopathology. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Boredom Coping Scale
KW  - Personality Measures
KW  - Test Development
KW  - Attentional Control
KW  - Psychometric Properties
KW  - Intrinsic Enjoyment
U5  - Boredom Coping Scale (BC) [Test Development]Intrinsic Enjoyment and Boredom Coping scales: Validation with personality, evoked potential and attention measures. (AN: 1985-08405-001 from PsycINFO) Hamilton, Jean A.; Haier, Richard J.; Buchsbaum, Monte S.; 1984. Source: Personality and Individual Differences. 5(2), Elsevier Science, Netherlands; 1984; Administration: Paper Age Group: Adolescence (13-17 yrs), Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Community College Students; Nursing Students; High School Students Keywords: Boredom Coping Scale; Personality Measures; Test Development; Attentional Control; Psychometric Properties; Intrinsic Enjoyment; Subjects: Boredom; Coping Behavior; Personality Measures; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t13546-000
L3  - Full; Full text; 999913546_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-13546-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-13545-000
AN  - 9999-13545-000
AU  - Hamilton, Jean A.
AU  - Haier, Richard J.
AU  - Buchsbaum, Monte S.
T1  - Intrinsic Enjoyment Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1984///
AD  - Hamilton, Jean A., CRB/DERP/NIMH, Center for Studies of Affective Disorders, Biology of Depression Research Unit, Room 10-C-26, Parklawn Building, 5600 Fishers Lane, Rockville, Maryland, United States, 20857
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-13545-000. Acronyms: IE. Partial author list: First Author & Affiliation: Hamilton, Jean A.; National Institute of Mental Health, Clinical Neuropharmacology Branch, Bethesda, Maryland, United States. Release Date: 20120813. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: Intrinsic Enjoyment Scale items involve a forced choice between an intrinsic and extrinsic self-characterization of one’s 'likes' or 'feelings' across different situations. Each intrinsic statement receives 1 point so that scores can range from 0-9, with high scores suggesting more intrinsic enjoyment.. Language: English. Constructs: Intrinsic Enjoyment; Classification: Emotional States, Emotional Responses, and Motivation (6000). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Intrinsic Enjoyment Scale is to assess intrinsic enjoyment, characterized by intense involvement, interest and absorbed concentration.
AB  - Description: The Intrinsic Enjoyment Scale (IE; Hamilton,Haier, & Buchsbaum, 1984) was developed to assesss intrinsic enjoyment, characterized by intense involvement, interest and absorbed concentration. Using a set of 13 statements derived from Csikszentmihalyi’s work (1975) which were consistently identified as reflecting intrinsic enjoyment by a card-sort method, a set of 9 items were chosen with a forced choice between an intrinsic and extrinsic self-characterization of one’s 'likes' or 'feelings' across different situations. Each intrinsic statement receives 1 point so that scores could range from 0-9, with high scores suggesting more intrinsic enjoyment. In a sample of high school students, Cronbach’s coefficient alpha for the IE was .40. The test-retest reliability for nursing students was 0.68. Construct validity was established by comparison with personality tests, real-life measures, and laboratory measures of attention. Intrinsic enjoyment correlated with intrinsic involvement, the affective experience of potency, concentrating well with ease, high ego development, internal locus of control, lack of boredom susceptibility, attentional change and cortical augmenting. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Intrinsic Enjoyment Scale
KW  - Personality Measures
KW  - Test Development
KW  - Psychometric Properties
U5  - Intrinsic Enjoyment Scale (IE) [Test Development]Intrinsic Enjoyment and Boredom Coping scales: Validation with personality, evoked potential and attention measures. (AN: 1985-08405-001 from PsycINFO) Hamilton, Jean A.; Haier, Richard J.; Buchsbaum, Monte S.; 1984. Source: Personality and Individual Differences. 5(2), Elsevier Science, Netherlands; 1984; Administration: Paper Age Group: Adolescence (13-17 yrs), Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Community College Students; Nursing Students; High School Students Keywords: Intrinsic Enjoyment Scale; Personality Measures; Test Development; Psychometric Properties; Subjects: Personality Measures; Pleasure; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t13545-000
L3  - Full; Full text; 999913545_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-13545-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-24372-000
AN  - 9999-24372-000
AU  - Hunter, Fumiyo Tao
T1  - Authority-Reciprocity Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1984///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-24372-000. Partial author list: First Author & Affiliation: Hunter, Fumiyo Tao; National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland, United States. Release Date: 20131111. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Location: Table 1, Page 1094. Test Format: Each procedure item is rated on a 4-point Likert-type scale (1 = hardly ever, 2 = not often, 3 = often, 4 = very often). Each reason item is rated on a 4-point Likert-type scale (1 = not my reason at all, 2 = little like my reason, 3 = close to my reason, 4 = my main reason). Scale scores are computed for each relation as unweighted averages.. Language: English. Constructs: Father Child Relations; Interpersonal Interaction; Mother Child Relations; Peer Relations; Classification: Social, Group, and Interpersonal Relationships (7600); Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Authority-Reciprocity Questionnaire is to assess patterns of socializing interactions in adolescents' relations with mothers, fathers, and friends.
AB  - Description: The Authority-Reciprocity Questionnaire (Hunter, 1984) was developed to assess patterns of socializing interactions in adolescents' relations with mothers, fathers, and friends. The interactional patterns are assessed by items describing the other person's behavior in Direct Influence and Social Verification contexts, reasons for the person's attempt at direct influence, and reasons for adolescent's seeking social verification from the person. The items adhere closely to statements spontaneously generated by children and adolescents in previous works. All scales consist of eight items (four procedures and four reasons), except for the Unilateral Social Verification scale, which contains seven items. Each item is rated on a 4-point Likert-type scale. Four scale scores are computed for each relation (mother, father, friend) as unweighted averages from the items a priori designated for Unilateral Direct Influence, Mutual Direct Influence, Unilateral, and Mutual Social Verification scales. In a sample of early, middle, and late adolescents, the internal consistencies (Cronbach's alpha) of the scales ranged from .54-.83. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Unilateral and Mutual Social Verification Scales
KW  - Authority-Reciprocity Questionnaire
KW  - Test Development
KW  - Internal Consistency
KW  - Adolescents' Relations with Mothers
KW  - Fathers
KW  - and Friends
KW  - Unilateral and Mutual Direct Influence Scales
U5  - Authority-Reciprocity Questionnaire [Test Development]Socializing procedures in parent–child and friendship relations during adolescence. (AN: 1987-34083-001 from PsycINFO) Hunter, Fumiyo T.; Nov, 1984. Source: Developmental Psychology. 20(6), American Psychological Association, US; Nov, 1984; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Students (Ages 12-20); Location: United States Keywords: Unilateral and Mutual Social Verification Scales; Authority-Reciprocity Questionnaire; Test Development; Internal Consistency; Adolescents' Relations with Mothers, Fathers, and Friends; Unilateral and Mutual Direct Influence Scales; Subjects: Adolescent Development; Family Relations; Peer Relations; Rating Scales; Social Influences; Socialization; Test Construction; Test Reliability;
DO  - 10.1037/t24372-000
L3  - Partial; Full text; 999924372_partial_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - GEN
AU  - Wyngaarden, J B
T1  - A worldwide problem in medical research
JO  - A worldwide problem in medical research
JF  - A worldwide problem in medical research
Y1  - 1984///
M3  - Book
AB  - The subject of this address, 'A Worldwide Problem in Medical Research' has multiple dimensions, but central to it is the stability of university-based research-stability of financial support for established investigators and for the continuous production of well-trained medical scientists. Book Published by Taylor Graham, United Kingdom, 1984
KW  - MEDICINE
KW  - Research
KW  - United kingdom
KW  - Universities
N1  - Accession Number: ISTA2001217; Wyngaarden, J B 1; Affiliations: 1 : National Institutes of Health, Bethesda, MD;  Source Info: 1984; Note: Place of Publication: United Kingdom; Note: Update Code: 2000; Subject Term: MEDICINE; Author-Supplied Keyword: Research; Author-Supplied Keyword: United kingdom; Author-Supplied Keyword: Universities; Document Type: Book
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Binkerd, P.E.
AU  - Hendrickx, A.G.
AU  - Rice, J.M.
AU  - Palmer, A.E.
T1  - Embryonic Development in Erythrocebus patas.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1984/01//
VL  - 6
IS  - 1
M3  - Article
SP  - 15
EP  - 29
SN  - 02752565
AB  - The developmental stages of 12 Erythrocebus patas embryos, ranging in gestational age from 30 to 50 days, is described. The pattern of embryogenesis in E. patas closely parallels the anatomic characteristics of human and other nonhuman primate embryos between stages 12 and 23. However, there is a delay in development in E. patas similar to that observed in human embryos which differs from the macaques and baboons. This temporal difference in the embryonic period is an important factor in the design and analysis of early pregnancy studies in this species. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PATAS monkey
KW  - EMBRYOS
KW  - EMBRYOLOGY
KW  - PREGNANCY in animals
KW  - DEVELOPMENTAL biology
KW  - ANIMAL morphology
KW  - MONKEYS
KW  - PRIMATES
N1  - Accession Number: 12258513; Binkerd, P.E. 1 Hendrickx, A.G. 1 Rice, J.M. 2 Palmer, A.E. 2; Affiliation:  1: California Primate Research Center, University of California, Davis  2: Laboratory of Comparative Carcinogenesis, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of health, Frederick, Maryland; Source Info: 1984, Vol. 6 Issue 1, p15; Subject Term: PATAS monkey; Subject Term: EMBRYOS; Subject Term: EMBRYOLOGY; Subject Term: PREGNANCY in animals; Subject Term: DEVELOPMENTAL biology; Subject Term: ANIMAL morphology; Subject Term: MONKEYS; Subject Term: PRIMATES; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hartge, Patricia
AU  - Cahill, John I.
AU  - West, Dee
AU  - Hauck, Mary
AU  - Austin, Donald
AU  - Silverman, Debra
AU  - Hoover, Robert
T1  - Design and Methods in a Multi-Center Case-Control Interview Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/01//
VL  - 74
IS  - 1
M3  - Article
SP  - 52
EP  - 56
PB  - American Public Health Association
SN  - 00900036
AB  - We conducted a case-control study in ten areas of the United States in which a total of 2,982 bladder cancer patients and 5,782 population controls were interviewed. We employed a variety of existing and new techniques to reduce bias and to monitor the quality of data collected. We review here many of the design elements and field methods that can be generally applied in epidemiologic studies, particularly multi-center interview studies, and explain the reasons for our selection of the methods, instruments, and procedures used. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLADDER cancer
KW  - CANCER patients
KW  - BLADDER diseases
KW  - EPIDEMIOLOGY -- Research
KW  - UNITED States
N1  - Accession Number: 4954175; Hartge, Patricia 1 Cahill, John I. 2 West, Dee 3 Hauck, Mary 4 Austin, Donald 4 Silverman, Debra 5 Hoover, Robert 6; Affiliation:  1: Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Room 3C 06, 7910 Woodmont Avenue, Bethesda, MD 20205  2: Westat, Inc.  3: University of Utah  4: California Department of Health Services  5: Biometry Branch, NCI  6: Environmental Epidemiology Branch, NCI; Source Info: Jan1984, Vol. 74 Issue 1, p52; Subject Term: BLADDER cancer; Subject Term: CANCER patients; Subject Term: BLADDER diseases; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eaton, William W.
AU  - McLeod, Jane
T1  - Consumption of Coffee or Tea and Symptoms of Anxiety.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/01//
VL  - 74
IS  - 1
M3  - Article
SP  - 66
EP  - 68
PB  - American Public Health Association
SN  - 00900036
AB  - The relationship of consumption of coffee or tea to self-reported symptoms of anxiety is examined with data from the detailed examination component of the National Center for Health Statistics Health and Nutrition Examination Survey. Among this nationwide sample of 3,854 respondents, there was no significant association between consumption of coffee or tea and symptoms of anxiety. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANXIETY
KW  - COFFEE
KW  - TEA
KW  - STRESS (Psychology)
KW  - HEALTH surveys -- United States
KW  - UNITED States
KW  - NATIONAL Center for Health Statistics (U.S.)
N1  - Accession Number: 4954182; Eaton, William W. 1 McLeod, Jane 2; Affiliation:  1: Center for Epidemiologic Studies, National Institute of Mental Health.  2: Center for Epidemiologic Studies, National Institute of Mental Health; Source Info: Jan1984, Vol. 74 Issue 1, p66; Subject Term: ANXIETY; Subject Term: COFFEE; Subject Term: TEA; Subject Term: STRESS (Psychology); Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 111339 Other Noncitrus Fruit Farming; NAICS/Industry Codes: 111330 Non-citrus fruit and tree nut farming; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311920 Coffee and Tea Manufacturing; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Burger, R.
AU  - Scher, I.
AU  - Sharrow, Susan O.
AU  - Shevach, E. M.
T1  - Non-activated guinea-pig T cells and thymocytes express Ia antigens: FACS analysis with alloantibodies and monoclonal antibodies.
JO  - Immunology
JF  - Immunology
Y1  - 1984/01//
VL  - 51
IS  - 1
M3  - Article
SP  - 93
EP  - 102
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Conventional alloantisera and monoclonal antibodies to guinea-pig Ia antigens were used for analysis of Ia expression by guinea-pig T cells and thymocytes. Indirect immunofluorescent staining was performed with alloantisera or with ascitic fluid as a source of monoclonal antibody followed by flow microfluorometry analysis on the fluorescence activated cell sorter. About 80% of normal, non-activated peritoneal exudate T cells, lymph node T cells and thymocytes expressed Ia antigens. These data are therefore in contrast to studies with human or murine T cells where Ia antigens were shown to be expressed predominantly on activated but not on non-activated T cells. All the reactivity of the anti-Ia alloantisera for strain 2 T cells could be removed by absorption with an Ia-bearing B cell leukaemia, EN-L2C, but not by its Ia-negative variant, BZ-L2C. Thus, the Ia determinants identified on T and B cells are probably identical. One monoclonal antibody, 25E3, which had previously been shown by serologic analysis to react exclusively with an alloantigenic determinant of strain 2 Ia antigens displayed an unusual pattern of reactivity in that it clearly stained strain 13 thymocytes, but not mature strain 13 T or B lymphocytes. The significance of this possible expression of inappropriate Ia determinants by thymocytes remains unclear. This phenomenon might be associated with differentiation processes in the thymus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - MONOCLONAL antibodies
KW  - GLYCOPROTEINS
KW  - IMMUNOGENETICS
KW  - LYMPH nodes
KW  - LYMPHOID tissue
N1  - Accession Number: 13400278; Burger, R. 1 Scher, I. 2 Sharrow, Susan O. 3 Shevach, E. M. 4; Affiliation:  1: Institut für Med. Mikrobiologie, Mainz, West Germany.  2: Naval Medical Research National Cancer Institute, Bethesda.  3: Immunology Branch, National Cancer Institute, Bethesda.  4: Laboratory of Immunology, National institute of Allergy and Infectious Diseases, Bethesda, Maryland. U.S.A.; Source Info: Jan1984, Vol. 51 Issue 1, p93; Subject Term: IMMUNOGLOBULINS; Subject Term: MONOCLONAL antibodies; Subject Term: GLYCOPROTEINS; Subject Term: IMMUNOGENETICS; Subject Term: LYMPH nodes; Subject Term: LYMPHOID tissue; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cohen, Yinon
AU  - Pfeffer, Jeffrey
T1  - Employment Practices in the Dual Economy.
JO  - Industrial Relations
JF  - Industrial Relations
Y1  - 1984///Winter84
VL  - 23
IS  - 1
M3  - Article
PB  - Wiley-Blackwell
SN  - 00198676
AB  - The purpose of this paper is to empirically examine whether or not there are significant associations between an establishment's industrial sector location and a large number of employment practices that have been taken to be defining characteristics of labor market segmentation. This focus helps to move the debate over the usefulness of dual economy theory away from a concern solely with differences in attainment processes (Zucker and Rosenstein, 1981; Tolbert et al., 1980; Beck et al., 1978) towards considering whether there is evidence for differences in employers' labor market behavior across economic sectors. We examine aspects of the relationship between industrial sector and labor market practices by drawing from the literature general and specific hypotheses and then testing these using data from a sample of more than 300 Northern California employers. Our results are mixed. The connections between sectoral location and labor practices are not consistent, and there is no evidence of segmentation into primary and secondary labor markets. These empirical findings seriously challenge dual economy theorists' assertion that the structure of the economy significantly affects labor market processes and is ultimately responsible for the emergence of segmented labor markets. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Industrial Relations is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LABOR supply
KW  - DUAL economy
KW  - LABOR market
KW  - EMPLOYEE selection
KW  - INDUSTRIAL location
KW  - MARKET segmentation
KW  - ECONOMIC structure
KW  - AGRARIAN societies
KW  - NORTH Carolina
KW  - UNITED States
N1  - Accession Number: 4550665; Cohen, Yinon 1; Pfeffer, Jeffrey 2; Affiliations: 1: Postdoctoral Fellow, National Institute of Mental Health, Organizations Research Training Program, Stanford University; 2: Professional of Organizational Behavior, Graduate School of Business, Stanford University; Issue Info: Winter84, Vol. 23 Issue 1; Thesaurus Term: LABOR supply; Thesaurus Term: DUAL economy; Thesaurus Term: LABOR market; Thesaurus Term: EMPLOYEE selection; Thesaurus Term: INDUSTRIAL location; Thesaurus Term: MARKET segmentation; Thesaurus Term: ECONOMIC structure; Thesaurus Term: AGRARIAN societies; Subject: NORTH Carolina; Subject: UNITED States; NAICS/Industry Codes: 561320 Temporary Help Services; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Roy-Byrne, Peter
AU  - Lee-Benner, Karen
AU  - Yager, Joel
T1  - Group Therapy for Bulimia.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1984///Winter1984
VL  - 3
IS  - 2
M3  - Article
SP  - 97
EP  - 116
PB  - John Wiley & Sons, Inc.
SN  - 02763478
N1  - Accession Number: 12071621; Roy-Byrne, Peter 1 Lee-Benner, Karen 2 Yager, Joel 3,4; Affiliation:  1: Medical Staff Fellow, National Institute of Mental Health, Biological Psychiatry Branch  2: Clinical Coordinator,. UCLA Eating Disorders Clinic, University of California at Los Angeles Neuropsychiatric Instittue  3: Professor of Psychiatry, UCLA Eating Disorders Clinic, University of California at Los Angeles Neuropsychiatric Institute  4: Director, UCLA Eating Disorders Clinic, University of California at Los Angeles Neuropsychiatric Institute; Source Info: Winter1984, Vol. 3 Issue 2, p97; Number of Pages: 20p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cummings, E. Mark
AU  - Zahn-Waxler, Carolyn
AU  - Radke-Yarrow, Marian
T1  - DEVELOPMENTAL CHANGES IN CHILDREN'S REACTIONS TO ANGER IN THE HOME.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1984/01//
VL  - 25
IS  - 1
M3  - Article
SP  - 63
EP  - 74
SN  - 00219630
AB  - Marital disharmony and family tension have repeatedly been associated with antisocial behavior and emotional problems in children. There is evidence that discord within the home may be a more significant factor titan the break-up of the family in the development of deviant behavior. However, researchers have not examined children's responses to specific family episodes indicative of disharmony. Patterns of responding to others' negative emotional interactions may constitute an important link in an analysis of the processes through which conflict in the home impacts upon children.
KW  - FAMILIES
KW  - ANTISOCIAL personality disorders
KW  - EMOTIONAL problems of children
KW  - DEVIANT behavior
KW  - CHILD psychology
N1  - Accession Number: 12815063; Cummings, E. Mark 1 Zahn-Waxler, Carolyn 1 Radke-Yarrow, Marian 1; Affiliation:  1: National Institute Of Mental Health, Bethesda, MD, U.S.A.; Source Info: Jan1984, Vol. 25 Issue 1, p63; Subject Term: FAMILIES; Subject Term: ANTISOCIAL personality disorders; Subject Term: EMOTIONAL problems of children; Subject Term: DEVIANT behavior; Subject Term: CHILD psychology; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1469-7610.ep12815063
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fine, Jo-David
AU  - Breathnach, Stephen M.
AU  - Hintner, Helmut
AU  - Katz, Stephen I.
T1  - KF-1 Monoclonal Antibody Defines a Specific Basement Membrane Antigen Defect in Dystrophic Forms of Epidermolysis Bullosa.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/01//
VL  - 82
IS  - 1
M3  - Article
SP  - 35
EP  - 38
SN  - 0022202X
AB  - The monoclonal antibody, KF- 1, identifies a noncollagenous constituent of the lamina densa of the basement membrane zone (BMZ) of skin. In order to determine whether this BMZ constituent is affected in epidermolysis bullosa (EB), a mechanobullous skin disease often resulting in marked disfigurement, we have examined skin from patients with various forms of this disease for binding by KF-1 as well as for binding by polyclonal antibodies to laminin, type IV collagen, and bullous pemphigoid antigen, three other known BMZ components of normal skin. In all specimens from patients with simplex and junctional forms of EB, all four antibodies bound normally. In contrast, absent or diminished KF-1 binding was noted in all skin specimens from patients with dystrophic EB; antibodies directed against the other BMZ constituents, however, bound normally. This suggests that KF-1 may play a role in the structural integrity of normal skin and its absence or diminution may be important in the pathogenesis of lesion formation in dystrophic EB. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - IMMUNOGLOBULINS
KW  - MOLECULAR cloning
KW  - BASAL lamina
KW  - EPIDERMOLYSIS bullosa
KW  - ANTIGENS
KW  - COLLAGEN
N1  - Accession Number: 12259063; Fine, Jo-David 1 Breathnach, Stephen M. 2 Hintner, Helmut 3 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Visiting Associate of the National Cancer Institute and a Dowling Travelling Fellow of the British Association of Dermatologists.  3: Recipient of a Max Kade Foundation Fellowship.; Source Info: Jan1984, Vol. 82 Issue 1, p35; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: MOLECULAR cloning; Subject Term: BASAL lamina; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: ANTIGENS; Subject Term: COLLAGEN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12259063
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fine, Jo-David
AU  - Neises, Gabrielle R.
AU  - Katz, Stephen I.
T1  - Immunofluorescence and Immunoelectron Microscopic Studies in Cicatricial Pemphigoid.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/01//
VL  - 82
IS  - 1
M3  - Article
SP  - 39
EP  - 43
SN  - 0022202X
AB  - We have studied various tissues from 10 patients with cicatricial pemphigoid using direct and indirect immunofluorescence, mechanical suction blister induction, and immunoelectron microscopy. In 8 of the 10 patients, direct immunofluorescence of buccal mucosa showed a linear deposition of immunoreactants, IgG and C3 being those most commonly detected. Direct immunofluorescence of skin was positive in only 4 patients. Only 1 patient had a detectable circulating anti-basement membrane zone antibody. Substitution of normal human oral mucosa for adult skin as the tissue substrate for indirect immunofluorescence did not prove useful in the detection of circulating autoantibodies. Immunoelectron microscopy was performed in the skin or mucosa (buccal or ocular) of 6 patients, revealing lamina lucida localization of in vivo-bound immunoreactants. Indirect immunofluorescence studies on mechanically induced suction blisters in skin of 2 patients with in vivo-bound IgG suggest that the lamina lucida antigen involved in cicatricial pemphigoid may be distinct from the bullous pemphigoid antigen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOFLUORESCENCE
KW  - ORAL mucosa
KW  - AUTOANTIBODIES
KW  - IMMUNOGLOBULINS
KW  - SKIN diseases
KW  - MICROSCOPY
N1  - Accession Number: 12259075; Fine, Jo-David 1 Neises, Gabrielle R. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1984, Vol. 82 Issue 1, p39; Subject Term: IMMUNOFLUORESCENCE; Subject Term: ORAL mucosa; Subject Term: AUTOANTIBODIES; Subject Term: IMMUNOGLOBULINS; Subject Term: SKIN diseases; Subject Term: MICROSCOPY; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12259075
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Woodley, David T.
AU  - Katz, Stephen I.
T1  - Identification and Partial Characterization of Pemphigoid Antigen Extracted from Normal Human Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/01//
VL  - 82
IS  - 1
M3  - Article
SP  - 108
EP  - 111
SN  - 0022202X
AB  - Antibodies in the sera of patients with the disease bullous pemphigoid define a normal component of the basement membrane of stratified squamous epithelia. Pemphigoid antigen has been shown to be synthesized by mouse and human epidermal cells in culture as an approximately 220 kd protein when reduced. The purpose of this study was to characterize pemphigoid antigen extracted directly from normal human skin and to determine its relationship to the high molecular weight protein found in culture. Suction blister-derived epidermis was extracted with 2% sodium dodecyl sulfate (SDS) and the solubilized proteins were separated, after reduction, by SDS-polyacrylamide gel electrophoresis (PAGE). The separated proteins were electrophoretically transferred to nitrocellulose sheets. Pemphigoid antigen was then specifically identified by immunoperoxidase staining using pemphigoid sera. IgG from 5 different bullous pemphigoid patients bound a band of apparent molecular weight 225 kd. Antibodies from 6 normal sera and 4 pemphigus sera did not bind this molecule. On a lower percentage (4%) polyacrylamide gel the pemphigoid antigen could be resolved as a doublet (two closely spaced bands) in the range of 220-240 kd. When unreduced, the pemphigoid antigen extracted from skin was also detected as a doublet in the 220-240 kd range. This suggests that the two chains are not necessarily disulfide-linked to each other in skin. Newly synthesized pemphigoid antigen immunoprecipitated from extracts of cultured human epidermal cells could also be identified on SDS-PAGE, when reduced, as a doublet in the 220-240 kd range. Taken together these data demonstrate that the pemphigoid antigen can be extracted directly from normal human skin and is a molecule similar in molecular weight to the antigen synthesized in human epidermal cell culture. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - ANTIGENS
KW  - BASAL lamina
KW  - EPITHELIAL cells
KW  - PROTEINS
KW  - IMMUNOENZYME technique
KW  - CELL culture
N1  - Accession Number: 12259224; Stanley, John R. 1,2,3 Woodley, David T. 1,2,3 Katz, Stephen I. 1,2,3; Affiliation:  1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A.  2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda, Maryland, U.S.A.  3: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1984, Vol. 82 Issue 1, p108; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Subject Term: BASAL lamina; Subject Term: EPITHELIAL cells; Subject Term: PROTEINS; Subject Term: IMMUNOENZYME technique; Subject Term: CELL culture; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12259224
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2005-09719-004
AN  - 2005-09719-004
AU  - Strauss, John S.
AU  - Bowers, Malcolm B. Jr.
AU  - Keith, Samuel J.
AU  - Bleuler, Manfred
ED  - Strauss, John S.
ED  - Bowers, Malcolm B. Jr.
ED  - Keith, Samuel J.
T1  - What Is Schizophrenia?
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1984///
VL  - 10
IS  - 1
SP  - 8
EP  - 10
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Keith, Samuel J., Center for Studies of Schizophrenia, Clinical Research Branch, National Institute of Mental Health, 5600 Fishers Lane, Rm. 10C-18, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09719-004. Partial author list: First Author & Affiliation: Strauss, John S.; Center for Studies of Schizophrenia, Clinical Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Schizophrenia; Symptoms. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 3. Issue Publication Date: 1984. 
AB  - One of the main questions related to schizophrenia is, naturally enough, what is it? Such a question may seem obvious, naive, impossible, or any combination of these. And certainly it is a bit demanding to expect that anyone could say what schizophrenia is in 1,000 words. On the other hand, we felt that it was worth the effort. We hope that presenting these brief discussions on 'what is schizophrenia' by persons who have worked extensively in the field will allow the reader to note areas of overlap and disagreement as well as variations in emphasis. Although no one may yet be able to provide the definitive answer, at least this collection of informed opinions may help clarify the major questions. The essay by Manfred Bleuler is the sixth in this series. Further collections of these statements will be presented in subsequent issues. Readers' responses and comments are cordially invited. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - symptoms
KW  - 1984
KW  - Schizophrenia
KW  - Symptoms
KW  - 1984
DO  - 10.1093/schbul/10.1.8
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06408-063
AN  - 2006-06408-063
AU  - Waskow, Irene Elkin
T1  - Helping Relationships: A Single Process?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1984/01//
VL  - 29
IS  - 1
SP  - 72
EP  - 73
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06408-063. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Waskow, Irene Elkin; Treatment of Depression Collaborative Research Program, Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Assistance (Social Behavior); Clients; Self-Perception. Minor Descriptor: Self-Efficacy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Wills, Thomas Ashby (Ed). Basic Processes in Helping Relationships=New York: Academic Press, 1982. 543 pp. $39.50; 1982. References Available: Y. Page Count: 2. Issue Publication Date: Jan, 1984. 
AB  - Reviews the book, Basic Processes in Helping Relationships edited by Thomas Ashby Wills (1982). The editor's promise 'to integrate current research on basic psychological processes in helping relationships' goes largely unfulfilled. The organization and content of the individual chapters do not provide such an integration, nor do most of the chapters deal directly with what the editor sees as the major issues to be addressed, that is, the process through which the helper-client relationship actually develops and how it is related to such factors as the client's self-perceptions, expectations for improvement, and general self efficacy and perceived control. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological processes
KW  - helper client relationship
KW  - helping relationships
KW  - clients
KW  - self perceptopm
KW  - self efficacy
KW  - 1984
KW  - Assistance (Social Behavior)
KW  - Clients
KW  - Self-Perception
KW  - Self-Efficacy
KW  - 1984
U2  - Wills, Thomas Ashby (Ed). (1982); Basic Processes in Helping Relationships; New York: Academic Press, 1982. 543 pp. $39.50
DO  - 10.1037/022580
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Haseman, J. K.
AU  - Crawford, D. D.
AU  - Huff, J. E.
AU  - Boorman, G. A.
AU  - McConnell, E. E.
T1  - Results from 86 two‐year carcinogenicity studies conducted by the national toxicology program.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1984/01/03/
VL  - 14
IS  - 5/6
M3  - Article
SP  - 621
EP  - 639
SN  - 00984108
AB  - Five categories of evidence of carcinogenicity in rats and mice were used to group interpretative results on 86 chemicals studied in recent carcinogenicity tests carried out by the National Toxicology Program (NTP). Of these studies, 50% (43/86) were regarded as showing carcinogenic effects, 42% (36/86) gave no evidence of carcinogenicity, 6% (5/86) showed equivocal evidence of carcinogenicity, and 2% (2/86) were regarded as inadequate experiments. The liver was the most frequent site of cancer in male and female Fischer‐344 rats and in male and female B6C3F1 mice. Male rats appeared more sensitive than female rats to the induction of neoplasia, while for mice the females seemed more responsive. The routes of administration yielding the highest percentage (80–83%) of positive studies were gavage and inhalation; approximately one‐third of the feed, drinking water, and dermal studies showed carcinogenic effects. In feeding studies, overall survival in dosed and control groups were similar, while the majority of gavage studies showed significantly reduced survival in one or more dosed groups relative to the corresponding controls. The overall percentage of studies showing carcinogenic effects (50%) agrees closely with the rate reported by other investigators for nearly 200 earlier carcinogenicity experiments conducted by the National Cancer Institute. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75457095; Haseman, J. K. 1 Crawford, D. D. 2 Huff, J. E. 3 Boorman, G. A. 3 McConnell, E. E. 3; Affiliation:  1: Biometry and Risk Assessment Program, National Institute of Environmental Health Science, P.O. Box 12233, Research Triangle Park, North Carolina, 27709  2: Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina  3: National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Source Info: Jan1984, Vol. 14 Issue 5/6, p621; Number of Pages: 19p; Document Type: Article
L3  - 10.1080/15287398409530613
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goering, Peter L.
AU  - Klaassen, Curtis D.
T1  - Tolerance to cadmium‐induced toxicity depends on presynthesized metallothionein in liver.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1984/01/03/
VL  - 14
IS  - 5/6
M3  - Article
SP  - 803
EP  - 812
SN  - 00984108
AB  - Tolerance to Cd‐induced toxicity following pretreatment with Cd is well documented, yet the exact mechanism of tolerance and role of metailothionein (MT) remains equivocal. In this study it was determined if the rapid induction of MT following injection of a challenge dose of Cd or the concentration of presynthesized MT induced by Cd pretreatment is more important for development of tolerance by ascertaining (1) whether the rates of synthesis of MT differ following injection of the challenge dose of Cd in control and Cd‐pretreated rats and (2) if a relationship exists between presynthesized hepatic or renal MT and tolerance to Cd‐induced lethality. Rates of hepatic and renal MT synthesis did not differ following injection of a challenge dose of Cd (2.0 mg Cd/kg, iv) in control and Cd‐pretreated (2.0 mg Cd/kg, sc) rats. However, the progressive increase in concentration of MT in liver after Cd pretreatment correlated with the increase in tolerance to a lethal dose of Cd (4.0 mg Cd/kg, iv), as evidenced by a decrease in mortality in pretreated rats. A similar correlation was not observed between kidney MT levels and tolerance. Therefore, it appears that presynthesized MT in liver rather than increased synthesis of MT following injection of a second dose of Cd is responsible for Cd‐induced tolerance. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75457110; Goering, Peter L. 1,2 Klaassen, Curtis D. 3; Affiliation:  1: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, 27709  2: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas  3: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, 66103; Source Info: Jan1984, Vol. 14 Issue 5/6, p803; Number of Pages: 10p; Document Type: Article
L3  - 10.1080/15287398409530628
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - NAHARRO, GERMAN
AU  - ROBBINS, KEITH C.
AU  - REDDY, E. PREMKUMAR
T1  - Gene Product of v-fgr onc: Hybrid Protein Containing a Portion of Actin and a Tyrosine-Specific Protein Kinase.
JO  - Science
JF  - Science
Y1  - 1984/01/06/
VL  - 223
IS  - 4631
M3  - Article
SP  - 63
EP  - 66
SN  - 00368075
AB  - The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, P70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region Of p70ms-fv is closely related to the tyrosinespecific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692056; NAHARRO, GERMAN 1; ROBBINS, KEITH C. 1; REDDY, E. PREMKUMAR 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p63; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - ELESPURU, R. K.
AU  - GONDA, S. K.
T1  - Activation of Antitumor Agent Gilvocarcins by Visible Light.
JO  - Science
JF  - Science
Y1  - 1984/01/06/
VL  - 223
IS  - 4631
M3  - Article
SP  - 69
EP  - 71
SN  - 00368075
AB  - Gilvocarcins that are antitumor agents are activated by low doses of visible light to induce bacteriophage lambda in Escherichia coli. This result is dependent on interaction with DNA. Gilvocarcin M, an analog without antitumor activity, failed to induce the prophage after light exposure, thus demonstrating a correlation between photosensitizing and antitumor activities. These results raise several possibilities regarding the mode of action of gilvocarcins as antitumor agents in vivo, involving light or enzymatic activating systems, which could be exploited in human cancer therapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692058; ELESPURU, R. K. 1; GONDA, S. K. 1; Affiliations: 1: National Cancer Institute- Frederick Cancer Research Facility, Fermentation Program, Frederick, Maryland 21701; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p69; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BONNER, TOM
AU  - O'BRIEN, STEPHEN J.
AU  - NASH, WILLIAM G.
AU  - RAPP, ULF R.
AU  - MORTON, CYNTHIA C.
AU  - LEDER, PHILIP
T1  - The Human Homologs of the raf (mil) Oncogene Are Located on Human Chromosomes 3 and 4.
JO  - Science
JF  - Science
Y1  - 1984/01/06/
VL  - 223
IS  - 4631
M3  - Article
SP  - 71
EP  - 74
SN  - 00368075
AB  - Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692059; BONNER, TOM 1; O'BRIEN, STEPHEN J. 1; NASH, WILLIAM G. 1; RAPP, ULF R. 1; MORTON, CYNTHIA C. 2; LEDER, PHILIP 2; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p71; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GRAVELL, MANETH
AU  - LONDON, WILLIAM T.
AU  - HOUFF, SIDNEY A.
AU  - MADDEN, DAVID L.
AU  - DALAKAS, MARINOS C.
AU  - SEVER, JOHN L.
AU  - OSBORN, KENT G.
AU  - MAUL, DONALD H.
AU  - HENRICKSON, ROY V.
AU  - MARX, PRESTON A.
AU  - LERCHE, NICHOLAS W.
AU  - PRAHALADA, SRINIVASA
AU  - GARDNER, MURRAY B.
T1  - Transmission of Simian Acquired Immunodeficiency Syndrome (SAIDS) with Blood or Filtered Plasma.
JO  - Science
JF  - Science
Y1  - 1984/01/06/
VL  - 223
IS  - 4631
M3  - Article
SP  - 74
EP  - 76
SN  - 00368075
AB  - Simian acquired immunodeficiency syndrome (SAIDS), a disease clini-cally and pathologically similar to acquired immunodeficiency syndrome in humans, was transmittedfrom diseased rhesus monkeys (Macaca mulatta) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through and most probably a virus. No viruses, however, were isolated by standard cell culture techniques from the blood or filtered plasma which caused SAIDS. Both cellular and humoral immunity were markedly depressed in animals with advanced SAIDS. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692060; GRAVELL, MANETH 1; LONDON, WILLIAM T. 1; HOUFF, SIDNEY A. 1; MADDEN, DAVID L. 1; DALAKAS, MARINOS C. 1; SEVER, JOHN L. 1; OSBORN, KENT G. 2; MAUL, DONALD H. 2; HENRICKSON, ROY V. 2; MARX, PRESTON A. 2; LERCHE, NICHOLAS W. 2; PRAHALADA, SRINIVASA 2; GARDNER, MURRAY B. 3; Affiliations: 1: Infectious, Diseases Branch, National Institute for Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; 2: California Primate Research Center, University of California, Davis 95616; 3: Department of Pathology, School of Medicine, University of California, Davis 95616; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p74; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - PAUL, S. M.
AU  - HAUGER, R. L.
AU  - HULIHAN-GIBLIN, B. A.
AU  - SKOLNICK, P.
T1  - Analyzing Nonlinear Scatchard Plots.
JO  - Science
JF  - Science
Y1  - 1984/01/06/
VL  - 223
IS  - 4631
M3  - Article
SP  - 76
EP  - 78
SN  - 00368075
N1  - Accession Number: 84692061; PAUL, S. M. 1; HAUGER, R. L. 1; HULIHAN-GIBLIN, B. A. 1; SKOLNICK, P. 2; Affiliations: 1: Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p76; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SRINIVASAN, A.
AU  - REDDY, E. PREMKUMAR
AU  - DUNN, CLAIRE Y.
AU  - AARONSON, STUART A.
T1  - Molecular Dissection of Transcriptional Control Elements Within the Long Terminal Repeat of the Retrovirus.
JO  - Science
JF  - Science
Y1  - 1984/01/20/
VL  - 223
IS  - 4633
M3  - Article
SP  - 286
EP  - 289
SN  - 00368075
AB  - The' retroviral long -erminal repeat (LTR) contains transcriptional control elements that affect viral gene expression. By deletion mutagenesis of the genome of the cloned Abelson murine leukemia virus, regulatory signals could be mapped to at least three domains within the LTR. A defective 5' LTR that did not sustain transforming gene function was complemented by an intact LTR positioned at the 3' end of the genotne. This versatility of the retroviral genome with respect to its transcriptional control elements appears to provide a strong selective advantage for viral gene expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84672077; SRINIVASAN, A. 1; REDDY, E. PREMKUMAR 1; DUNN, CLAIRE Y. 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland,0205; Issue Info: 1/20/1984, Vol. 223 Issue 4633, p286; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Morin, Michele M.
AU  - Pickle, Linda Williams
AU  - Mason, Thomas J.
T1  - Geographic Patterns of Ethnic Groups in the United States.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/02//
VL  - 74
IS  - 2
M3  - Article
SP  - 133
EP  - 139
PB  - American Public Health Association
SN  - 00900036
AB  - The geographic distributions of 11 major ethnic groups within the United States, based on 1960 census data, are illustrated by computer-generated state economic area maps. The Scandinavian, German, and Russian ethnic groups were similarly concentrated primarily in the North Central region, while the Irish, Polish, Other East European, and South European groups were clustered predominantly in the Northeast. Other ethnic groups had patterns which were different from either of the above. These maps correspond to the atlases of mortality from cancer and other diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POPULATION
KW  - ETHNIC groups
KW  - DEMOGRAPHIC surveys
KW  - PUBLIC health
KW  - UNITED States
N1  - Accession Number: 4952605; Morin, Michele M. 1 Pickle, Linda Williams 1 Mason, Thomas J. 1; Affiliation:  1: Environmental Epidemiology Branch, National Cancer Institute, 3C29 Landow Building, Bethesda, MD 20205; Source Info: Feb1984, Vol. 74 Issue 2, p133; Subject Term: POPULATION; Subject Term: ETHNIC groups; Subject Term: DEMOGRAPHIC surveys; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kessler, Larry G.
T1  - Treated Incidence of Mental Disorders in a Prepaid Group Practice Setting.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/02//
VL  - 74
IS  - 2
M3  - Article
SP  - 152
EP  - 154
PB  - American Public Health Association
SN  - 00900036
AB  - We followed a cohort of 7,666 individuals enrolled continuously for five years in a prepaid group practice in Columbia, Maryland. Incidence rates of all diagnosed mental disorders were estimated at approximately 3.7 per cent, lower for adolescents and children (about 3 per cent), higher for adult males aged 20-49 (4.3 per cent), and highest for adult females (5.8 per cent). Diagnoses are primarily for acute mental disorders and show a tendency to recur at fairly high rates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD psychiatry
KW  - MENTAL illness
KW  - HEALTH maintenance organizations
KW  - GROUP medical practice
KW  - COLUMBIA (Md.)
KW  - MARYLAND
N1  - Accession Number: 4953120; Kessler, Larry G. 1; Affiliation:  1: Division of Biometry and Epidemiology, National Institute of Mental Health, Parklawn Building, Room 18C-14, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Feb1984, Vol. 74 Issue 2, p152; Subject Term: CHILD psychiatry; Subject Term: MENTAL illness; Subject Term: HEALTH maintenance organizations; Subject Term: GROUP medical practice; Subject Term: COLUMBIA (Md.); Subject Term: MARYLAND; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06409-034
AN  - 2006-06409-034
AU  - Shore, Milton F.
T1  - The Ecology of Delinquency.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1984/02//
VL  - 29
IS  - 2
SP  - 145
EP  - 146
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06409-034. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shore, Milton F.; Satellite Clinic, Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Family Therapy; Juvenile Delinquency; Psychopathology. Minor Descriptor: Schools; Social Influences; Social Issues. Classification: Criminal Behavior & Juvenile Delinquency (3236); Group & Family Therapy (3313). Population: Human (10). Reviewed Item: Henggeler, Scott W. (Ed). Delinquency and Adolescent Psychopathology: A Family-Ecological Systems Approach=Boston: Wright, 1982. 270 pp. $25.00; 1982. References Available: Y. Page Count: 2. Issue Publication Date: Feb, 1984. 
AB  - Reviews the book, Delinquency and Adolescent Psychopathology: A Family-Ecological Systems Approach edited by Scott W. Henggeler (1982). The editor of the book under review, his colleagues, and a large number of doctoral students have written a series of comprehensive research summaries in the area of adolescent delinquency on such topics as classification, family therapy, the influence of social class, and the effect of different school settings on behavior to show the need for an ecological framework for the topic. In each case they stress the importance of seeing the youths within their social contexts and the interweaving individual, family, and community factors. The major purpose of the book seems to be to make a case for the ecological model as contrasted with an individual psychopathological model, in understanding and treating antisocial behavior. This book also leaves out recent environmental design and urban planning areas and gives only limited attention to issues of social policy in relation to ecology. The book also has an elementary description of the different approaches to family therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adolescent delinquency
KW  - adolescent psychopathology
KW  - family-ecological systems
KW  - social class
KW  - family therapy
KW  - school settings
KW  - 1984
KW  - Family Therapy
KW  - Juvenile Delinquency
KW  - Psychopathology
KW  - Schools
KW  - Social Influences
KW  - Social Issues
KW  - 1984
U2  - Henggeler, Scott W. (Ed). (1982); Delinquency and Adolescent Psychopathology: A Family-Ecological Systems Approach; Boston: Wright, 1982. 270 pp. $25.00
DO  - 10.1037/022650
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - JOSEPHS, STEVEN F.
AU  - Guo, CHAN
AU  - RATNER, LEE
AU  - WONG-STAAL, FLOSSIE
T1  - Human Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus.
JO  - Science
JF  - Science
Y1  - 1984/02/03/
VL  - 223
IS  - 4635
M3  - Article
SP  - 487
EP  - 491
SN  - 00368075
AB  - The nucleotide sequences of the six regions within the normal human cellular locus (c-sis) that correspond to the entire transforming region of the simian sarcoma virus (SSV) genome (v-sis) were determined. The regions are bounded by acceptor and donor splice sites and, except for region 6, resemble exons. Region 6 lacks a 3' donor splice site and terminates -5 base pairsfrom the 3' v-sis-helper-viral junction. This is consistent with a model proposing that SSV was generated by recombination between proviral DNA ofsimian sarcoma associated virus andprotosis and that introns were spliced out subsequently from a fused viral-sis messenger RNA. This also suggests that the 3' recombination occurred within an exon of the woolly monkey (Lagotlirix) genome. The open reading frames predicting the v-sis and c-sis gene products coincide with the stop codon ofc-sis located 123 nucleotides into the fifth region of homology. The overall nucleotide homology was 91 percent with substitutions mainly in the third codon positions within the open reading frame and with greatest divergence within the untranslated 3' portion of the sequences. The predicted protein products for v-sis and c-sis are 93 percent homologous. The predicted c-sis gene product is identical in 31 of 31 amino acids to one of the published sequences ofplatelet-derived growth factor. Thus, c-sis encodes one chain of human platelet-derived growth factor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84672111; JOSEPHS, STEVEN F. 1; Guo, CHAN 1; RATNER, LEE 1; WONG-STAAL, FLOSSIE 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 2/ 3/1984, Vol. 223 Issue 4635, p487; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Simpson, Andrew J. G.
AU  - Dame, John B.
AU  - Lewis, Fred A.
AU  - McCutchan, Thomas F.
T1  - The arrangement of ribosomal RNA genes in <em>Schistosoma mansoni</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/02/15/
VL  - 139
IS  - 1
M3  - Article
SP  - 41
EP  - 45
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The two large ribsomal RNA subunits of Schistosoma mansoni are encoded within a 10000-base sequence, which is tandemly repeated in the schistosome genome. Restriction endonuclease digestion with Bam HI cuts the rRNA gene into three fragments, which have been cloned separately in pBR322 and used to constract a physical map of the gene. The sequence encoding the smaller rRNA subunit is about 2000 bases in length and is situated on the 5′ sie of the sequence encoding the larger subunit, which is about 4000 bases. Approximately 4000 bases of the rRNA gene are spacer and do not code for mature rRNA. There are approximately 100 copies of the rRNA gene per haploid genome of which about 10% exhibit length heterogeneity, as judged by the hybridization of the rDNA plasmids to restriction endonuclease digests of genomic DNA. These structural variants appear to contain additional DNA suquences at more than one site within the gene and are polymorphic within the species S. mansoni. [ABSTRACT FROM AUTHOR]
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KW  - RIBOSOMES
KW  - RNA
KW  - SCHISTOSOMA mansoni
KW  - NUCLEOTIDE sequence
KW  - PLASMIDS
KW  - GENETIC polymorphisms
KW  - GENETICS
N1  - Accession Number: 13867778; Simpson, Andrew J. G. 1 Dame, John B. 2 Lewis, Fred A. 3 McCutchan, Thomas F. 2; Affiliation:  1: Division of Parasitology, National Institute for Medical Research of the Medical Research Council, The Ridgeway, Mill Hill, London, England, NW7 1AA  2: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institute of Health, 900 Rockville Pike, Bethesda, Maryland, USA 20205  3: Medical Research Institute, Rockville, Maryland, USA 20852; Source Info: 2/15/84, Vol. 139 Issue 1, p41; Subject Term: RIBOSOMES; Subject Term: RNA; Subject Term: SCHISTOSOMA mansoni; Subject Term: NUCLEOTIDE sequence; Subject Term: PLASMIDS; Subject Term: GENETIC polymorphisms; Subject Term: GENETICS; Number of Pages: 5p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Prakash, Chandra
AU  - Katial, Albine
AU  - Kang, Mohinder S.
AU  - Vijay, Iner K.
T1  - Solubilization of mannosyltransferase activities for the biosynthesis of mammary glycoproteins.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/02/15/
VL  - 139
IS  - 1
M3  - Article
SP  - 87
EP  - 93
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The microsomal preparation from the lactating bovine mammary tissue was solubilized by treatment with nonionic detergent, NP-40, at a protein/detergent ratio of 1.5:1 and a detergent concentration of 0.5%. Following centrifugation at 147000 × g for 120 rnin, the supernatant fraction was incubated with labeled sugar nucleotides, GDP-Man and UDP-GlcNAc. It was found to synthesize a series of lipid-linked saccharides up to (Man)5- (GlcNAc)2. The solubilized glycosyltransferases retained up to about 60% of the activity after two weeks of storage at 4°C. The biosynthesis of glycolipids was stimulated by a mixture of lipids obtained by extracting the mammary microsomes with CHCl3/CH3OH (2:1). A labeled lipid-linked tetrasaccharide of the structure Man&alpha1→3ManΒ→GlcNAcΒGlcNAc was isolated by labeling baby hamster kidney cells with [2-3H]mannose under conditions of glucose starvation followed by extraction of the cells with CHCl3/CH3OH (2:1) and separation of the lipids by hiigh-performance liquid chromatography. When this lipid-linked tetrasaccharide was incubated with the solubilized bovine mammary microsomes and GDP-Man, it was elongated to a lipid-linked heptasaccharide having the structure Manα1→2Manα1&rar;2Manα1→3(Manα1→6)ManΒ→GlcNAcΒ→GIcNAc. The kinetics of the elongation reaction also revealed the intermediary formation of smaller amounts of lipid-linked pentasaccharide and hexasaccharide. The elongation reaction did not require any divalent metal ion and had a broad pH optimum between 6.8 and 7.6. The lack of inhibition of the elongation reaction by EDTA or amphomycin support earlier studies that GDP-Man rather than mannosylphosphoryldolichol, is the direct donor of mannosyl residues for the biosynthesis of glycolipids up to (Man)5(GlcNAc)2. Mannosylphosphorylretinol was ineffective as rnannosyl donor for the elongation reaction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLYCOPROTEIN synthesis
KW  - ENZYMES
KW  - PROTEINS
KW  - NUCLEOTIDES
KW  - SACCHARIDES
KW  - GLYCOSYLTRANSFERASES
KW  - GLYCOPROTEINS
N1  - Accession Number: 13868093; Prakash, Chandra 1 Katial, Albine 1 Kang, Mohinder S. 2 Vijay, Iner K. 1; Affiliation:  1: Department of Animal Sciences, University of Maryland, College Park, Maryland, USA 20742  2: Laboratory of Biochemistry and Metabolism, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20205; Source Info: 2/15/84, Vol. 139 Issue 1, p87; Subject Term: GLYCOPROTEIN synthesis; Subject Term: ENZYMES; Subject Term: PROTEINS; Subject Term: NUCLEOTIDES; Subject Term: SACCHARIDES; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: GLYCOPROTEINS; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - KAN, NANCY C.
AU  - FLORDELLIS, CHRISTOS S.
AU  - MARK, GEORGE E.
AU  - DUESBERG, PETER H.
AU  - PAPAS, TAKIS S.
T1  - A Common onc Gene Sequence Transduced by Avian Carcinoma Virus MH2 and by Murine Sarcoma Virus 3611.
JO  - Science
JF  - Science
Y1  - 1984/02/24/
VL  - 223
IS  - 4638
M3  - Article
SP  - 813
EP  - 816
SN  - 00368075
AB  - A common cellular sequence was independently transduced by avian carcinoma virus MH2 (v-mht) and murine sarcoma virus (MSV) 3611 (v-raf). Comparison of the nucleotide sequences of v-mht and v-raf revealed a region of homology that extends over 969 nucleotides. The homology between the corresponding amino acids was about 95 percent with only 19 of 323 amino acids being different. With this example, S of the 19 known different viral onc genes have been observed in viruses of different taxonomic groups. These data indicate that (i) the number of cellular proto-onc genes is limited because, like other viruses of different taxonomic groups, MH2 and MSV3611 have transduced the same onc gene-specific sequences from different cell species and (ii) that specific deletion and linkage of the same proto-onc sequences to different viral vector elements affect the oncogenic potential of the resulting viruses. The difference in transformation capabilities of MH2 and MSV 3611 serves as an example. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84679912; KAN, NANCY C. 1; FLORDELLIS, CHRISTOS S. 1; MARK, GEORGE E. 2; DUESBERG, PETER H. 3; PAPAS, TAKIS S. 4; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 3: Laboratory of Molecular Biology, University of California, Berkeley 94740; 4: Laboratory of Molecular Oncology, National Cancer Institute; Issue Info: 2/24/1984, Vol. 223 Issue 4638, p813; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Adhya, Sankar
T1  - Mobile Genetic Elements (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1984/03//Mar/Apr84
VL  - 72
IS  - 2
M3  - Book Review
SP  - 204
SN  - 00030996
AB  - Reviews the book 'Mobile Genetic Elements,' edited by James A. Shapiro.
KW  - Mobile genetic elements
KW  - Nonfiction
KW  - Mobile Genetic Elements (Book)
N1  - Accession Number: 11079611; Adhya, Sankar 1; Affiliations: 1: National Cancer Institute; Issue Info: Mar/Apr84, Vol. 72 Issue 2, p204; Thesaurus Term: Mobile genetic elements; Subject Term: Nonfiction; Reviews & Products: Mobile Genetic Elements (Book); Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Shock, N. W.
T1  - AGING.
JO  - BioScience
JF  - BioScience
Y1  - 1984/03//
VL  - 34
IS  - 3
M3  - Book Review
SP  - 188
EP  - 188
SN  - 00063568
AB  - Reviews the book 'Biological Markers of Aging,' by Mitchell E. Roff and Edward L. Schneider.
KW  - Aging
KW  - Nonfiction
KW  - Roff, Mitchell
KW  - Schneider, Edward
KW  - Biological Markers of Aging (Book)
N1  - Accession Number: 10098323; Shock, N. W. 1; Affiliations: 1: National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, MD 21224; Issue Info: Mar1984, Vol. 34 Issue 3, p188; Subject Term: Aging; Subject Term: Nonfiction; Reviews & Products: Biological Markers of Aging (Book); People: Roff, Mitchell; People: Schneider, Edward; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 529
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DB  - eih
ER  - 

TY  - JOUR
AU  - Hall, Russell P
AU  - Leiserson, William M.
AU  - Chused, Thomas M
AU  - Lawley, Thomas J
T1  - Characterization of T Lymphocyte and Monocyte Populations in HLA B8/DRw3 Normal Individuals and in Patients with Dermatitis Herpetiformis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/03//
VL  - 82
IS  - 3
M3  - Article
SP  - 231
EP  - 234
SN  - 0022202X
AB  - Normal individuals who possess the HLA B8/DRw3 haplotype as well as patients with dermatitis herpetiformis have been found to have a number of immunologic abnormalities including decreased numbers of E rosette-positive, Fe IgG receptor-bearing lymphocytes (referred to as TG cells), and increased numbers of cells which spontaneously secrete immunoglobulin, HLA B8/DRw3-positive normal individuals also have an increased risk for the development of a number of immunologically mediated diseases. Since many of these findings are suggestive of B-cell hyperreactivity and since TG cells were initially thought to represent a portion of the T suppressor cell network, we have examined the peripheral blood mononuclear (PBM) cell populations of 14 normal HLA B8/DRw3-positive individuals, 14 patients with dermatitis herpetiformis (all of whom were HLA B8/DRw3-positive), and 9 non-HLA B8/DRw3 individuals using flow cytometry and monoclonal antibodies of the OK and Leu series directed against cell surface antigens. Normal HLA B8/DRw3 individuals were found to have a significantly lower percentage of PBM cells that expressed both OKTS and Leu-2a when compared to normal non-HLA B8/DRw3 individuals (p < .05 Student's <em>t</em>-test). When the ratio of T helper cells (OKT4 and Leu-3a) to T suppressor cells (OKT8 and Leu-2a) was calculated for each individual studied, normal HLA B8/DRw3 individuals were found to have a significantly elevated ratio (Leu-3a/Leu-2a = 2.41 ± .16, mean ± SEM) when compared to non-HLA selected individuals (Leu-3a/Leu-2a = 1.73 ± .05) (p < 0.025). In addition, normal HLA B8/DRw3 individuals had decreased numbers of TG cells when compared to normal non-HLA B8/DRw3 individuals (B8/DRw3 = 6.4 ± .74%, non-B8/ DRw3 = 13.2 ± 1.0%, mean ± SEM, p < .01). In order to determine the cell surface marker characteristics of TG cells, purified TG cells from both normal HLA B8/DRw3 individuals and non-HLA B8/DRw3 individuals were studied using the Leu series monoclonal antibodies and OKM1. Good agreement was found in the percentages of cells expressing each cell surface marker between the two groups. In addition, the TG cells were found to be predominately T cells (78% Leu-1-positive), with both T helper cells (40% Leu-3a-positive) and T suppressor cells (30% Leu-2a-positive) present. These results suggest that the suppressor cell activity associated with the TG subset is not due to a depletion of the T helper cell subset, and that the decreased numbers of TG cells in HLA B8/DRw3 individuals is not due to a preferential loss of cells bearing Leu-1, Leu-2a, Leu-3a, or 0KM 1. The significant elevation of the T helper (OKT4, Leu-3a)/T suppressor (OKT8, Leu-2a) ratio in normal HLA B8/DRw3 individuals represents further documentation of immunologic abnormalities present in normal LILA B8/DRw3 individuals. The elevation of this T helper/T suppressor ratio in these otherwise normal individuals may play a role in their increased risk for the development of immunologic diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DERMATITIS herpetiformis
KW  - LYMPHOCYTES
KW  - MONOCYTES
KW  - IMMUNOGLOBULINS
KW  - T cells
KW  - FLOW cytometry
N1  - Accession Number: 12260103; Hall, Russell P 1 Leiserson, William M. 2 Chused, Thomas M 2 Lawley, Thomas J 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Maryland, U.S.A.  2: Laboratory of Microbiological Immunity, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1984, Vol. 82 Issue 3, p231; Subject Term: DERMATITIS herpetiformis; Subject Term: LYMPHOCYTES; Subject Term: MONOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: T cells; Subject Term: FLOW cytometry; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12260103
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DB  - aph
ER  - 

TY  - RPRT
AU  - McConnell, E. E.
AU  - Lucier, G. W.
AU  - Rumbaugh, R. C.
AU  - Albro, P. W.
AU  - Harvan, D. J.
AU  - Hass, J. R.
AU  - Harris, M. W.
T1  - Dioxin in Soil: Bioavailability After Ingestion by Rats and Guinea Pigs.
JO  - Science
JF  - Science
Y1  - 1984/03/09/
VL  - 223
IS  - 4640
M3  - Report
SP  - 1077
EP  - 1079
SN  - 00368075
AB  - This article presents information on a study related to the effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) in soil on rats and guinea pigs. TCDD is a highly toxic compound found as a contaminant in phenoxy acid herbicides, chlorophenols, and other related chemicals, appears highly persistent in soil except when exposed to sunlight. This compound binds tightly to soil and usually remains on or near the soil surface. After a single dose of TCDD, the guinea pigs were observed for 30 days. Necropsies were performed on animals that died during or were killed at the end of the study and selected tissues were examined histopathologically. The brain, thymus, spleen, liver, right kidney, and testicle from animals killed at the end of the study were weighed. A portion of liver was frozen for TCDD analysis, which after extraction was analyzed as described for soil. The clinicopathologic effects in guinea pigs exposed to either TCDD in corn oil or in contaminated soil were comparable. These animals either failed to gain weight or lost weight and died in a severe state of cachexia from 5 to 21 days after exposure.
KW  - Tetrachlorodibenzodioxin
KW  - Soils
KW  - Guinea pigs as laboratory animals
KW  - Rats as laboratory animals
KW  - Autopsy
KW  - Liver
KW  - Endocrine glands
KW  - Spleen
N1  - Accession Number: 18880125; McConnell, E. E.; Lucier, G. W.; Rumbaugh, R. C. 1; Albro, P. W. 1; Harvan, D. J. 1; Hass, J. R. 1; Harris, M. W. 1; Affiliations: 1: National Institute of Environmental, Health Sciences, Box 12233, Research Triangle Park, North Carolina 27709.; Issue Info: 3/9/1984, Vol. 223 Issue 4640, p1077; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Soils; Subject Term: Guinea pigs as laboratory animals; Subject Term: Rats as laboratory animals; Subject Term: Autopsy; Subject Term: Liver; Subject Term: Endocrine glands; Subject Term: Spleen; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Report
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ER  - 

TY  - RPRT
AU  - Marquardt, Hans
AU  - Hunkapiller, Michael W.
AU  - Hood, Leroy E.
AU  - Todaro, George J.
T1  - Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor.
JO  - Science
JF  - Science
Y1  - 1984/03/09/
VL  - 223
IS  - 4640
M3  - Report
SP  - 1079
EP  - 1082
SN  - 00368075
AB  - This article presents information on the chemical structure of the Rat Transforming Growth Factor Type-1 (rTGF-1). The structure of rTGF-1 and compositional data on the isolated Lys-C peptides are in agreement with the amino acid compositional data on the whole peptide. The proposed primary structure of rTGF-1 is supported by the finding that native rTGF-1 and its synthetic replicate do not differ significantly in their biological activities in vitro. rTGF-1 is a single-chain polypeptide of 50 residues with a calculated molecular weight of 5616. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of this material, of rTGF-1 isolated from Abelson murine leukemia virus-transformed Fischer rat embryo fibroblasts, and of human melanoma-derived hTGF-1 gave an apparent molecular weight of 7400. The discrepancy between molecular weight and mobility is not understood. The previously reported amino acid composition of hTGF-1was based on an assumed molecular weight of 7400, and thus the number of residues per mole was overestimated. However, the amino acid composition of hTGF-1 agrees well with the expected values by assigning a total of 50 residues.
KW  - Polyacrylamide
KW  - Chemical structure
KW  - Transforming growth factors
KW  - Biological response modifiers
KW  - Peptides
KW  - Colloids
KW  - Amino acids
KW  - Cytokines
N1  - Accession Number: 18880126; Marquardt, Hans 1; Hunkapiller, Michael W. 2; Hood, Leroy E. 3; Todaro, George J. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701.; 2: Applied Biosystems, Foster City, California 94404.; 3: Division of Biology, California Institute of Technology, Pasadena 91125.; Issue Info: 3/9/1984, Vol. 223 Issue 4640, p1079; Thesaurus Term: Polyacrylamide; Subject Term: Chemical structure; Subject Term: Transforming growth factors; Subject Term: Biological response modifiers; Subject Term: Peptides; Subject Term: Colloids; Subject Term: Amino acids; Subject Term: Cytokines; Number of Pages: 4p; Document Type: Report
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - RPRT
AU  - Arya, Suresh K.
AU  - Wong-Staal, Flossie
AU  - Gallo, Robert C.
T1  - T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected Cells.
JO  - Science
JF  - Science
Y1  - 1984/03/09/
VL  - 223
IS  - 4640
M3  - Report
SP  - 1086
EP  - 1087
SN  - 00368075
AB  - This article presents information on T-cell growth factor genes (TCGF). TCGF is required for the continuous proliferation of specifically activated mature T lymphocytes. Similarly, some neoplastic mature T cells require TCGF for their growth in vitro, although in some cases without the requirement of prior antigen and lectin activation. This is apparently because at least some of these cells already possess TCGF receptors. Some mature T cells infected with human T-cell leukemia-lymphoma virus (HTLV) require TCGF for growth early in culture. Subsequently, many of the HTLV-infected cell lines become independent of exogenously added TCGF. Some of these cell lines constitutively produce and respond to their own TCGF, while other cell lines do not elaborate detectable extra-cellular TCGF. The question thus arises whether the latter cell lines are truly independent of TCGF or produce small quantities of TCGF, sufficient for growth but undetectable by conventional assay procedures. Moreover, it is possible that these HTLV-infected cells produce TCGF that is not externalized and that would not be detected in extracellular medium.
KW  - Growth factors
KW  - T cells
KW  - Genes
KW  - Cell culture
KW  - Lymphocytes
KW  - Cytokines
KW  - Cell lines
N1  - Accession Number: 18880129; Arya, Suresh K. 1; Wong-Staal, Flossie 1; Gallo, Robert C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205.; Issue Info: 3/9/1984, Vol. 223 Issue 4640, p1086; Subject Term: Growth factors; Subject Term: T cells; Subject Term: Genes; Subject Term: Cell culture; Subject Term: Lymphocytes; Subject Term: Cytokines; Subject Term: Cell lines; Number of Pages: 2p; Document Type: Report
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DB  - eih
ER  - 

TY  - JOUR
AU  - Aitken, AlastairA.
AU  - Klee, Claude H.
AU  - Cohen, Philip
T1  - The structure of the B subunit of calcineurin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/03/15/
VL  - 139
IS  - 3
M3  - Article
SP  - 663
EP  - 671
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The complete primary structure of the B subunit of calcineurin (protein phosphatase 213) has been determined by automated sequence analysis. The protein consists of a single polypeptide chain of 168 residues, relative molecular mass 19200. The structure shows 35% identity with the sequence of calmodulin and 29 % with troponin C. Homology is mainly confined to the regions of the four putative Ca2+ .binding loops. The results demonstrate that the B subunit is a new member of this family of Ca2+ -binding proteins. The N-terminal glycine residue is blocked with the C14-saturated fatty acid myristic acid and the first four residues are very similar to those of the catalytic subunit of cyclic-AMP-dependent protein kinase which also contains a myristoyl blocking group. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALMODULIN
KW  - PHOSPHOPROTEIN phosphatases
KW  - CALCIUM-binding proteins
KW  - GLYCINE
KW  - PROTEIN kinases
KW  - AMINO acid neurotransmitters
N1  - Accession Number: 15818362; Aitken, AlastairA. 1 Klee, Claude H. 1 Cohen, Philip 1; Affiliation:  1: Protein Phosphorylation Group of the Medical Research Council, Department ol Biochemistry. University of Dundee  Laboratory of Biochemistry National Cancer Institute,; Source Info: 3/15/84, Vol. 139 Issue 3, p663; Subject Term: CALMODULIN; Subject Term: PHOSPHOPROTEIN phosphatases; Subject Term: CALCIUM-binding proteins; Subject Term: GLYCINE; Subject Term: PROTEIN kinases; Subject Term: AMINO acid neurotransmitters; Number of Pages: 9p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - MITSUYA, HIROAKI
AU  - Guo, HONG-GUANG
AU  - MEGSON, MARY
AU  - TRAINOR, CECELIA
AU  - REITZ JR., MARVIN S.
AU  - BRODER, SAMUEL
T1  - Transformation and Cytopathogenic Effect in an Immune Human T-Cell Clone Infected by HTLV-I.
JO  - Science
JF  - Science
Y1  - 1984/03/23/
VL  - 223
IS  - 4642
M3  - Article
SP  - 1293
EP  - 1296
SN  - 00368075
AB  - Human T-cell leukemia-lymphoma virus (HTLV) is a human C-type retrovirus that can transform T lymphocytes in vitro and is associated with certain T-cell neoplasms. Recent data suggest that, in the United States, patients with acquired immunodeficiency syndrome (AIDS), homosexual men with lymphadenopathy, and hemophiliacs have had significant exposure rates to HTLV, whereas matched and unmatched control American subjects have rarely been exposed to this agent. In the present experiments, T cells specifically reactive against HTLV were propagatedfrom a patient whose HTLV-bearing lymphoma was in remission. The T cells were cloned in the presence of the virus and an HTLV-specific cytotoxic T-cell clone was isolated. This clone was infected and transformed by the virus, with one copy of an HTLV-I provirus being integrated into the genome. This T-cell clone did not exhibit the normal dependence on T-cell growth factor (interleukin-2) and proliferated spontaneously in vitro. Exposure of the clone to HTLV-bearing, autologous tumor cells specifically inhibited its proliferation and resulted in its death. These results may have implications for HTLV-associated inhibition of T-cell responses. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672147; MITSUYA, HIROAKI 1; Guo, HONG-GUANG 1; MEGSON, MARY 1; TRAINOR, CECELIA 1; REITZ JR., MARVIN S. 1; BRODER, SAMUEL 1; Affiliations: 1: Clinical Oncology Program and Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 3/23/1984, Vol. 223 Issue 4642, p1293; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - FISCHINGER, PETER J.
T1  - Advanced Computing.
JO  - Science
JF  - Science
Y1  - 1984/03/30/
VL  - 223
IS  - 4643
M3  - Article
SP  - 1350
EP  - 1350
SN  - 00368075
N1  - Accession Number: 84672157; FISCHINGER, PETER J. 1; Affiliations: 1: National Cancer Institute, Building 31, Room 11A19, Bethesda, Maryland 2020S; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1350; Number of Pages: 1/2p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - ROSENBERG, STEVEN A.
AU  - GRIMM, ELIZABETH A.
AU  - MCGROGAN, MICHAEL
AU  - DOYLE, MICHAEL
AU  - KAWASAKI, ERNEST
AU  - KOTHS, KIRSTON
AU  - MARK, DAVID F.
T1  - Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli.
JO  - Science
JF  - Science
Y1  - 1984/03/30/
VL  - 223
IS  - 4643
M3  - Article
SP  - 1412
EP  - 1415
SN  - 00368075
AB  - The genefor interleukin-2 was isolatedfrom the Jurkat cell line andfrom normal peripheral blood lymphocytes and, when inserted in Escherichia coli, was expressed at high concentrations. This interleukin-2 was purified to apparent homogeneity and tested for biological activity in a variety of assays in vitro and in vivo. The recombinant lymphokine supports the growth of murine and human interleukin-2 dependent cell lines, enhances the generation of murine and human cytolytic cells in vitro, and generates lymphokine activated killer cells from murine and human lymphocytes. It has a serum half-life of 2 to 3 minutes in the mouse and significantly enhances the generation of cytolytic cells in vivo after alloimmunization. No functional differences between native and the recombinant interleukin-2 molecules have been detected. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672187; ROSENBERG, STEVEN A. 1; GRIMM, ELIZABETH A. 1; MCGROGAN, MICHAEL 2; DOYLE, MICHAEL 2; KAWASAKI, ERNEST 2; KOTHS, KIRSTON 2; MARK, DAVID F. 2; Affiliations: 1: Surgery Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 2: Cetus Corporation, Emeryville, California 94608; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1412; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - DE LANEROLLE, PRIMAL
AU  - NISHIKAWA, MASAKATSU
AU  - YOST, DAVID A.
AU  - ADELSTEIN, ROBERT S.
T1  - Increased Phosphorylation of Myosin Light Chain Kinase After an Increase in Cyclic AMP in Intact Smooth Muscle.
JO  - Science
JF  - Science
Y1  - 1984/03/30/
VL  - 223
IS  - 4643
M3  - Article
SP  - 1415
EP  - 1417
SN  - 00368075
AB  - The role of cyclic adenosine monophosphate-mediated phosphorylation of myosin light chain kinase in relaxing smooth muscle was examined. The kinase was immunoprecipitated from tissue extracts and the phosphate content was determined. The addition offorskolin to resting or methacholine-contracted muscles resulted in an increase in myosin light chain kinase phosphorylation and a relaxation of contracted muscles. These findings suggest that phosphorylation of myosin light chain kinase is one of the reactions in the process by which cyclic adenosine monophosphate causes relaxation of smooth muscle. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672188; DE LANEROLLE, PRIMAL 1; NISHIKAWA, MASAKATSU 1; YOST, DAVID A. 2; ADELSTEIN, ROBERT S. 3; Affiliations: 1: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 2: Laboratory of Metabolism, National Heart, Lung, and Blood Institute; 3: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1415; Number of Pages: 3p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - SACKS, DAVID L.
AU  - PERKINS, PETER V.
T1  - Identification of an Infective Stage of Leishmania Promastigotes.
JO  - Science
JF  - Science
Y1  - 1984/03/30/
VL  - 223
IS  - 4643
M3  - Article
SP  - 1417
EP  - 1419
SN  - 00368075
AB  - Sequential development of Leishmania promastigotes from a noninfective to an infective stage was demonstratedfor promastigotes growing in culture and in the sandfly vector. The generation of an infective stage was found to be growth cycle-dependent and restricted to nondividing organisms. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84672189; SACKS, DAVID L. 1; PERKINS, PETER V. 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20012; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1417; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Roitt, I. M.
AU  - Pujol-Borrell, R.
AU  - Hanafusa, T.
AU  - Delves, P. J.
AU  - Bottazzo, G. F.
AU  - Kohn, L. D.
T1  - Asialoagalactothyroglobulin binds to the surface of human thyroid cells at a site distinct from the 'microsomal' autoantigen.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1984/04//
VL  - 56
IS  - 1
M3  - Article
SP  - 129
EP  - 134
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Human thyroglobulin has been shown for the first time to bind to the surface of cultured human thyroid follicular cells. Binding was only observed with partially glycosylated asialoagalactothyroglobulin, not with the fully glycosylated iodoprotein. The binding site for asialoagalactothyroglobulin in the cell membrane is distinct from membrane associated microsomal/microvilli antigen. Since asialoagalactothyroglobulin bears the autoantigenic determinants of the parent molecule, its ability to bind to the thyroid cell surface suggests a possible role for this protein in the pathogenesis of human thyroiditis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYROGLOBULIN
KW  - CELL membranes
KW  - ANTIGENS
KW  - THYROIDITIS
KW  - PROTEINS
KW  - THYROID diseases
KW  - thyroglobulin
KW  - thyroid cell
KW  - thyroid microsomal antigen
KW  - thyroiditis
N1  - Accession Number: 17561485; Roitt, I. M. 1 Pujol-Borrell, R. 1 Hanafusa, T. 1 Delves, P. J. 1 Bottazzo, G. F. 1 Kohn, L. D. 2; Affiliation:  1: Department of Immunology, Middlesex Hospital Medical School, London, UK.  2: Section on Biochemistry of Cell Regulation, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1984, Vol. 56 Issue 1, p129; Subject Term: THYROGLOBULIN; Subject Term: CELL membranes; Subject Term: ANTIGENS; Subject Term: THYROIDITIS; Subject Term: PROTEINS; Subject Term: THYROID diseases; Author-Supplied Keyword: thyroglobulin; Author-Supplied Keyword: thyroid cell; Author-Supplied Keyword: thyroid microsomal antigen; Author-Supplied Keyword: thyroiditis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Henderson, W.R.
AU  - Harley, J.B.
AU  - Fauci, A.S.
T1  - Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 and 15-lipoxygenase products.
JO  - Immunology
JF  - Immunology
Y1  - 1984/04//
VL  - 51
IS  - 4
M3  - Article
SP  - 679
EP  - 686
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The formation of 5- and 15-lipoxygenase products of arachidonic acid metabolism was examined in human peripheral blood eosinophils obtained from five normal individuals and five patients with the hypereosinophilic syndrome (HES). Normal and HES eosinophils after stimulation with the calcium ionophore A23187 produced in comparable amounts leukotriene (LT)C4, LTD4, LTB4 and two of its isomers (5-(S),12-(R)-6-trans-LTB4 and 5-(S), 12-(S)-6-trans-LTB4), 15-hydroxy-eicosatetraenoic acid (HETE), 5,15-di-HETE and 8,15-di-HETE. No single lipoxygenase product predominated in the absence of added arachidonic acid whereas 15-HETE was the major product formed when either normal or HES eosinophils were stimulated with A23187 in the presence of added arachidonic acid (10-4 M). [ABSTRACT FROM AUTHOR]
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KW  - ARACHIDONIC acid
KW  - EOSINOPHILS
KW  - IONOPHORES
KW  - LEUKOTRIENES
KW  - LIPOXYGENASES
KW  - SYNDROMES
N1  - Accession Number: 13384915; Henderson, W.R. 1 Harley, J.B. 2 Fauci, A.S. 2; Affiliation:  1: Department of Medicine, University of Washington School of Medicine, Seattle, Washington  2: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr84, Vol. 51 Issue 4, p679; Subject Term: ARACHIDONIC acid; Subject Term: EOSINOPHILS; Subject Term: IONOPHORES; Subject Term: LEUKOTRIENES; Subject Term: LIPOXYGENASES; Subject Term: SYNDROMES; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Thivolet, Charles H.
AU  - Hintner, Helmut H.
AU  - Stanley, John R.
T1  - The Effect of Retinoic Acid on the Expression of Pemphigus and Pemphigoid Antigens in Cultured Human Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/04//
VL  - 82
IS  - 4
M3  - Article
SP  - 329
EP  - 334
SN  - 0022202X
AB  - Vitamin A and its derivatives (retinoids) have both profound effects on epidermal differentiation and beneficial therapeutic effects in various dermatologic diseases. In order to understand these effects, much work has been done with cultured keratinocytes, which show specific morphologic, cellular, and biochemical changes modulated by retinoids. In an attempt to further define specific molecular effects of retinoids in cultured human keratinocytes, we studied the expression of pemphigus (P) and pemphigoid (BP) antigens by human keratinocytes cultured with retinoic acid (RA) in concentrations which modulated differentiation. Cultures of human keratinocytes in medium with 10% delipidized fetal bovine serum (vitamin A-depleted medium) demonstrated areas of extensive differentiation with flattened stratifying cells, keratohyaline granules, and an anucleate stratum corneum-like superficial layer. These cells also synthesized a 67 kd keratin, characteristic of well-differentiated epidermis. In contrast, cultures of human keratinocytes in the same medium supplemented with (10-7 M, 3 × 10-7 M, or 10-6 M) RA demonstrated less differentiated small cuboidal cells that were stratified but did not form an anucleate layer or keratohyaline granules, and did not synthesize the 67 kd keratin. In order to detect P and BP antigens in these cultures, we used indirect immunofluorescence. In vitamin A-depleted cultures, P antigen either was not dectected or was seen focally on the cell surface of basal cells. BP antigen was seen on the basal pole of the basal cells, approximating its in vivo location. In RA-treated cells, P antigen was seen on the cell surface of most of the cells, and BP antigen was seen throughout the cytoplasm of the basal cells. In order to study the expression of newly synthesized antigens, we radiolabeled cultures with 14C-amino acids and quantitatively immunoprecipitated the antigens, which were then identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis.  We detected a major decrease in newly synthesized P antigen precipitated from extracts of vitamin A-depleted cells compared to RA-supplemented cells, whereas amounts of newly synthesized BP antigen were about the same.  Taken together these data demonstrate that RA, at concentrations that decrease differentiation of cultures human keratinocytes, increases the expression of P antigen and changes the subcellular location of BP antigen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRETINOIN
KW  - PEMPHIGUS
KW  - ANTIGENS
KW  - KERATINOCYTES
KW  - RETINOIDS
KW  - EPIDERMIS
KW  - IMMUNOFLUORESCENCE
N1  - Accession Number: 12260634; Thivolet, Charles H. 1,2 Hintner, Helmut H. 1,2 Stanley, John R. 1,2; Affiliation:  1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr84, Vol. 82 Issue 4, p329; Subject Term: TRETINOIN; Subject Term: PEMPHIGUS; Subject Term: ANTIGENS; Subject Term: KERATINOCYTES; Subject Term: RETINOIDS; Subject Term: EPIDERMIS; Subject Term: IMMUNOFLUORESCENCE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12260634
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06411-014
AN  - 2006-06411-014
AU  - Levy, Sandra M.
T1  - Distress, Coping, and Cancer: The Search for Evidence.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1984/04//
VL  - 29
IS  - 4
SP  - 297
EP  - 299
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06411-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Levy, Sandra M.; Behavioral Medicine Branch, National Cancer Institute, National Institutes of Health, Silver Spring, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Animal Ethology; Central Nervous System; Neoplasms; Stress. Minor Descriptor: Rats. Classification: Cancer (3293). Population: Human (10). Reviewed Item: Bammer, Kurt (Ed); Newberry, Benjamin H. (Ed). Stress and Cancer=Toronto, Canada: C. J. Hogrefe, 1981. 264 pp. $19.00; 1981. References Available: Y. Page Count: 3. Issue Publication Date: Apr, 1984. 
AB  - Reviews the book, Stress and Cancer edited by Kurt Bammer and Benjamin H. Newberry (1981). The purpose of the book includes presenting the perspectives of a variety of workers in the stress-cancer field and related areas without imposing editorial constraints. The purpose is worthy, the product is mixed at best and, on the whole, somewhat disappointing. The range of coverage extends from a specific focus on mammary cancers in rat and mouse models, to meteorological stress and cancer, to a wide-ranging attempt to link the central nervous system with neoplasia. The book is unique in focusing almost exclusively on experimental, laboratory research findings related to behavioral influence on neoplastic development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - stress
KW  - cancer
KW  - central nervous system
KW  - neoplasia
KW  - animal ethology
KW  - human
KW  - 1984
KW  - Animal Ethology
KW  - Central Nervous System
KW  - Neoplasms
KW  - Stress
KW  - Rats
KW  - 1984
U2  - Bammer, Kurt (Ed); Newberry, Benjamin H. (Ed). (1981); Stress and Cancer; Toronto, Canada: C. J. Hogrefe, 1981. 264 pp. $19.00
DO  - 10.1037/022778
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - KLEIN, DAVID C.
T1  - Melatonin and Puberty.
JO  - Science
JF  - Science
Y1  - 1984/04/06/
VL  - 224
IS  - 4644
M3  - Article
SP  - 6
EP  - 6
SN  - 00368075
N1  - Accession Number: 84672199; KLEIN, DAVID C. 1; Affiliations: 1: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 4/ 6/1984, Vol. 224 Issue 4644, p6; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - FAHEY, ROBERT C.
AU  - NEWTON, GERALD L.
AU  - ARRICK, BRADLEY
AU  - OVERDANK-BOGART, TOBIE
AU  - ALEY, STEPHEN B.
T1  - Entamoeba histolytica: A Eukaryote Without Glutathione Metabolism.
JO  - Science
JF  - Science
Y1  - 1984/04/06/
VL  - 224
IS  - 4644
M3  - Article
SP  - 70
EP  - 72
SN  - 00368075
AB  - Entamoeba histolytica was found to grow normally without producing glutathione and the main enzymes of glutathione metabolism, indicating that glutathione is not essentialfor many eukaryotic processes. This parasitic amoeba is an unusual eukaryote whose specialfeatures may help define the crucialfunctions of glutathione in those eukaryotes that do use it. Since Entamoeba histolytica lacks mitochondria and the usual aerobic respiratory pathways, the finding that it grows without glutathione and other evidence support the hypothesis that a primary function of glutathione in eukaryotes involves protection against oxygen toxicity associated with mitochondria and suggest that eukaryotes may have acquired glutathione metabolism at the time that they acquired mitochondria. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84672240; FAHEY, ROBERT C. 1; NEWTON, GERALD L. 1; ARRICK, BRADLEY 2; OVERDANK-BOGART, TOBIE 2; ALEY, STEPHEN B. 2,3; Affiliations: 1: Department of Chemistry, University of California, San Diego, La Jolla 92093; 2: Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021; 3: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20205; Issue Info: 4/ 6/1984, Vol. 224 Issue 4644, p70; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Tardif, Suzette D.
AU  - Richter, Conrad B.
AU  - Carson, Robert L.
T1  - Effects of Sibling-Rearing Experience on Future Reproductive Success in Two Species of Callitrichidae.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1984/05//
VL  - 6
IS  - 4
M3  - Article
SP  - 377
EP  - 380
SN  - 02752565
AB  - The survival rate for offspring of mothers who either had or did not have previous experience rearing younger siblings was compared in two callitrichid species, Callithrix jacchus and Saguinus oedipus. Offspring of mothers with sibling-rearing experience had a higher survival percentage than offspring of inexperienced mothers in both species. While 50–60% of offspring of inexperienced C jacchus mothers survived, no offspring of inexperienced S. oedipus mothers survived. The results suggest that sibling-rearing experience is necessary for adequate maternal behavior in S. oedipus, but not necessary to the development of maternal behavior in C. jacchus. Effects of previous sibling-rearing experience of S. oedipus fathers on offspring survival were also examined. Whether the father had rearing experience was not related to the survival of their offspring. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANIMAL breeding
KW  - SURVIVAL analysis (Biometry)
KW  - CHILD rearing
KW  - COTTONTOP tamarin
KW  - CALLITHRIX jacchus
KW  - ANIMAL behavior
KW  - SURVIVAL behavior (Animals)
KW  - ANIMAL psychology
KW  - PRIMATES
N1  - Accession Number: 12264888; Tardif, Suzette D. 1 Richter, Conrad B. 2 Carson, Robert L. 1; Affiliation:  1: Marmoset Research Center, Oak Ridge Associated Universities, Oak Ridge, Tennessee  2: National Institute of Environmental Health Sciences; Source Info: 1984, Vol. 6 Issue 4, p377; Subject Term: ANIMAL breeding; Subject Term: SURVIVAL analysis (Biometry); Subject Term: CHILD rearing; Subject Term: COTTONTOP tamarin; Subject Term: CALLITHRIX jacchus; Subject Term: ANIMAL behavior; Subject Term: SURVIVAL behavior (Animals); Subject Term: ANIMAL psychology; Subject Term: PRIMATES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 115210 Support Activities for Animal Production; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schulte, Paul A.
AU  - Ringen, Knut
T1  - Notification of Workers at High Risk An Emerging Public Health Problem.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/05//
VL  - 74
IS  - 5
M3  - Article
SP  - 485
EP  - 491
PB  - American Public Health Association
SN  - 00900036
AB  - During the last two decades, an increasing number of epidemiologic studies have found cohorts of workers to be at high risk or work-related chronic diseases, especially cancers. These studies frequently have led to the broad recognition of occupational hazards and eventually to the prevention of exposures to such hazards. Generally, however, the individual cohort members found to be at high risk have not been notified of study results, and programs of medical intervention or of palliative services directed at these individual workers have not been developed. Recently, the issue of whether or not workers have a right to be notified more directly about know health hazards to which they may have been exposed has emerged as a major, unresolved question in public health policy. Issues of concern include the criteria that should guide notifications; whom, when, and how to notify; and who should pay for notification and follow-up services. This commentary discusses the scientific, ethical, economic, and institutional aspects of worker notification, and describes three new demonstration projects that have provided notification and intervention for workers at high risk of bladder, colon, and lung cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INDUSTRIAL hygiene
KW  - OCCUPATIONAL hazards
KW  - OCCUPATIONAL health services
KW  - PUBLIC health
KW  - MEDICAL policy
KW  - MEDICAL care
N1  - Accession Number: 4958846; Schulte, Paul A. 1 Ringen, Knut 2; Affiliation:  1: Epidemiologist, Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226  2: National Cancer Institute, Division of Resources, Center and Community Activities, Bethesda, MD; Source Info: May84, Vol. 74 Issue 5, p485; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL hazards; Subject Term: OCCUPATIONAL health services; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: MEDICAL care; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoflerth, Sandra L.
T1  - LONG-TERM ECONOMIC CONSEQUENCES FOR WOMEN OF DELAYED CHILDBEARING AND REDUCED FAMILY SIZE.
JO  - Demography
JF  - Demography
Y1  - 1984/05//
VL  - 21
IS  - 2
M3  - Article
SP  - 141
EP  - 156
SN  - 00703370
AB  - Using data from the Panel Study of Income Dynamics, this study explored the association among delayed childbearing, completed family size and several measures of the economic well-being of women age 60 and older in 1976. By retirement age women who bore their first child at age 30 or older are significantly better off economically than either average-age childbearers or the childless. Economic well-being also appears to be related to family size among late childbearers. At retirement age the delayed childbearer with only one or two children appears better off than all other women. Thus, late childbearing and small family size appear associated with the highest standard of living for these women. This study also relates the experience of this early cohort of women to that of more recent birth cohorts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INCOME
KW  - FAMILY size
KW  - PANEL analysis
KW  - WOMEN
KW  - BIRTH intervals
KW  - NUCLEAR families
N1  - Accession Number: 16799490; Hoflerth, Sandra L. 1; Affiliations: 1: Center for Population Research, National Institute of Child Health and Human Development; Issue Info: May1984, Vol. 21 Issue 2, p141; Thesaurus Term: INCOME; Subject Term: FAMILY size; Subject Term: PANEL analysis; Subject Term: WOMEN; Subject Term: BIRTH intervals; Subject Term: NUCLEAR families; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Bennett, Peter H.
AU  - Davidson, Mayer B.
T1  - Diabetes in the elderly: Diagnosis and epidemiology.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1984/05//
VL  - 39
IS  - 5
M3  - Article
SP  - 37
EP  - 41
SN  - 0016867X
N1  - Accession Number: 18145284; Bennett, Peter H. 1; Davidson, Mayer B.; Source Information: May1984, Vol. 39 Issue 5, p37; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2712
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Saxena, Queen B.
AU  - Saxena, R. K.
AU  - Adler, W. H.
T1  - Effect of feeding a diet with half of the recommended levels of all vitamins on the natural and inducible levels of cytotoxic activity in mouse spleen cells.
JO  - Immunology
JF  - Immunology
Y1  - 1984/05//
VL  - 52
IS  - 1
M3  - Article
SP  - 41
EP  - 48
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Groups of 6-week-old female C57B1/6 mice were fed a normal diet with recommended levels of all vitamins Dr a vitamin-deficient (VD) diet containing half of the recommended level of each vitamin. At different time periods (1-11 weeks) after the initiation of diets, basal natural killer (NK) activity, interleukin-2 (IL-2) and concanavalin A (Con A)-induced cytotoxic activity, Con A-induced IL-2 production and levels of allospecific cytotoxic T cell activity generated in a mixed lymphocyte culture (MLC), were studied in spleen cells derived from control and VD mice. Results indicated that: (i) spleen NK activity remained normal until 2 weeks after the initiation of VD diet, fell steeply to tow levels at the 4 and 5 week time points and remained depressed thereafter; (ii) IL-2- and Con A-induced levels of cytotoxic activity in spleen cells derived from VD mice declined at 4 weeks alter the institution of VD diet, and then remained low throughout the study; (iii) the capacity of spleen cells from VD mice to generate IL-2 in response to Con A and cytotoxic T cells in response to allogeneic spleen cells, was normal at 1 and 4 weeks alter initiation of the VD diet and was markedly depressed at the 6 and 9 week time points. These results suggest that partial combined deficiencies of dietary vitamins strongly influence assays of immune function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VITAMINS
KW  - KILLER cells
KW  - CELL-mediated cytotoxicity
KW  - T cells
KW  - SPLEEN
KW  - INTERLEUKIN-2
KW  - MICE
N1  - Accession Number: 13506325; Saxena, Queen B. 1 Saxena, R. K. 1 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute of Aging, National Institutes of Health, Baltimore, Maryland, U.S.A.; Source Info: May84, Vol. 52 Issue 1, p41; Subject Term: VITAMINS; Subject Term: KILLER cells; Subject Term: CELL-mediated cytotoxicity; Subject Term: T cells; Subject Term: SPLEEN; Subject Term: INTERLEUKIN-2; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Snippe, H.
AU  - Van Houte, A. J.
AU  - Inman, J. K.
AU  - Lizzio, Elaine F.
AU  - Merchant, B.
T1  - Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.
JO  - Immunology
JF  - Immunology
Y1  - 1984/05//
VL  - 52
IS  - 1
M3  - Article
SP  - 87
EP  - 96
PB  - Wiley-Blackwell
SN  - 00192805
AB  - CBA/N mice harbour an X-linked B cell defect which is transmitted by CBA/N female mice to their hybrid male progeny. These mice mount normal responses to thymus-dependent (TD) and some thymus-independent (TI-1) antigens, while the response to TI-2 antigens is absent. Hapten-specific plaque-forming cell (PFC) responses to TD antigens can be blockaded by concomitant exposure of these mice to TI-2 antigens bearing the same hapten. This paper investigates in defective mice the blockade of their response to TNP3-LPS (trinitrophenylated lipopolysaccharide, a TI-1 antigen), imposed by DNP59-Ficoll (dinitrophenylated Ficoll, a TI-2 antigen). The effectiveness of the blocking agent, DNP59-Ficoll, differed in various inbred mouse strains: CBA/N × C3H/HeN F1 male > CBA/N female > CBA/N · C3H/HeN F1 female. The role of T cells in the observed hapten-specific blockade phenomenon was investigated using athymic CBA/N nude mice and a B cell tolerogen. Our findings indicate that T cell participation is not essential for the blockade of CBA/N PFC responses and they suggest that direct blockade of TI- and TD-responsive B cell populations is likely to occur. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAPTENS
KW  - B cells
KW  - ANTIGENS
KW  - IMMUNE response
KW  - THYMUS
KW  - CELL populations
KW  - MICE
N1  - Accession Number: 13506619; Snippe, H. 1 Van Houte, A. J. 1 Inman, J. K. 2 Lizzio, Elaine F. 3 Merchant, B. 3; Affiliation:  1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.  3: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: May84, Vol. 52 Issue 1, p87; Subject Term: HAPTENS; Subject Term: B cells; Subject Term: ANTIGENS; Subject Term: IMMUNE response; Subject Term: THYMUS; Subject Term: CELL populations; Subject Term: MICE; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Said, Jonathan W.
AU  - Sassoon, Aaron F.
AU  - Shintaku, I. Peter
AU  - Banks-Schlegel, Susan
T1  - Involucrin in Squamous and Basal cell Carcinomas of the Skin: An Immunohistochemical Study.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/05//
VL  - 82
IS  - 5
M3  - Article
SP  - 449
EP  - 452
SN  - 0022202X
AB  - Involucrin is a precursor of the cross-linked envelope protein of human stratum corneum, and its appearance in the upper layers of the epidermis is a function of the normal differentiation of the keratinocyte. Cases of basal cell and squamous cell carcinoma were evaluated for the presence of involucrin using immunoperoxidase techniques on paraffin sections. Basal cell carcinomas were negative for involucrin with staining restricted to squamous horn cysts, while squamous cell carcinomas stained strongly, particularly in large keratinized cells. Cases of squamous cell carcinoma in situ (Bowen's disease) revealed increased staining for involucrin with staining of dyskeratotic cells at all levels in the epithelium. Abnormal patterns of staining were also noted in non-neoplastic epidermis adjacent to carcinomas. Immunohistochemical staining for involucrin identifying abnormal or premature keratinization is a sensitive marker for dyskeratosis in squamous epithelia and may have applications in the histopathologic evaluation of skin specimens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN -- Cancer
KW  - BASAL cell carcinoma
KW  - SQUAMOUS cell carcinoma
KW  - IMMUNOHISTOCHEMISTRY
KW  - PROTEIN precursors
KW  - KERATINOCYTES
KW  - EPIDERMIS
N1  - Accession Number: 12260937; Said, Jonathan W. 1 Sassoon, Aaron F. 2 Shintaku, I. Peter 1 Banks-Schlegel, Susan 3; Affiliation:  1: Division of Anatomic Pathology, Cedars-Sinai Medical Center, Los Angeles, California.  2: Department of Biology, University of Southern California, Los Angeles, California, U. S. A..  3: Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: May84, Vol. 82 Issue 5, p449; Subject Term: SKIN -- Cancer; Subject Term: BASAL cell carcinoma; Subject Term: SQUAMOUS cell carcinoma; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: PROTEIN precursors; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12260937
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Otsuka, Fujio
AU  - Tarone, Robert E.
AU  - Cayeux, Sophie
AU  - Robbins, Jay H.
T1  - Use of Lymphoblastoid Cell Lines to Evaluate the Hypersensitivity to Ultraviolet Radiation in Cockayne Syndrome.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/05//
VL  - 82
IS  - 5
M3  - Article
SP  - 480
EP  - 484
SN  - 0022202X
AB  - Cockayne syndrome (CS) is a rare autosomal recessive disease characterized by acute sun sensitivity, cachectic dwarfism, and neurologic and skeletal abnormalities. Cultured skin fibroblasts from patients with this disease are known to be hypersensitive to the lethal effects of 254-nm UV radiation. We have studied the sensitivity to 254-nm UV radiation of lymphoblastoid lines derived from 3 typical CS patients, 1 atypical CS patient who had a very late age of onset of clinical manifestations, 2 patients who had both xeroderma pigmentosum (XP) and typical CS, and 3 heterozygous parents of these patients. Post-UV survival was determined by the trypan-blue dye-exclusion method. The lymphoblastoid lines from the 3 typical CS patients, the atypical CS patient, and the 2 patients with both CS and XP had decreased post-UV viability in comparison with lines from normal donors. Lines from the heterozygous parents had normal post-UV viability. The post-UV viability of the typical CS lines was similar to that of a XP complementation group C line. The relative post-UV viability of lymphoblastoid lines from the typical CS patients was similar to the relative post-UV survival of their fibroblast lines. The lymphoblastoid line from the atypical CS patient had a post-UV viability similar to that of the typical CS patients. Thus, the relative hypersensitivity of CS patients' cells in vitro does not reflect the severity or age of onset of the patients' clinical manifestations. The lymphoblastoid lines from the 2 patients who had both CS and XP were significantly more sensitive to the UV radiation than those from patients with only CS. Our studies demonstrate that lymphoblastoid lines from patients with CS are appropriate and useful cell lines for the study of the inherited hypersensitivity to UV radiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOBLASTOID cell lines
KW  - CELL culture
KW  - ULTRAVIOLET radiation -- Physiological effect
KW  - SYNDROMES
KW  - ALLERGY
KW  - IMMUNOLOGIC diseases
N1  - Accession Number: 12260999; Otsuka, Fujio 1,2 Tarone, Robert E. 1 Cayeux, Sophie Robbins, Jay H. 1; Affiliation:  1: Dermatology Branch and Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.  2: Department of Dermatology, University of Tokyo, Tokyo, 113, Japan.; Source Info: May84, Vol. 82 Issue 5, p480; Subject Term: LYMPHOBLASTOID cell lines; Subject Term: CELL culture; Subject Term: ULTRAVIOLET radiation -- Physiological effect; Subject Term: SYNDROMES; Subject Term: ALLERGY; Subject Term: IMMUNOLOGIC diseases; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12260999
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hintner, Helmut
AU  - Lawley, Thomas J.
T1  - Keratin Intermediate Filaments Bear Antigenic Determinants for Stratum Corneum Antibodies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/05//
VL  - 82
IS  - 5
M3  - Article
SP  - 491
EP  - 495
SN  - 0022202X
AB  - Stratum corneum (SC) antibodies are directed against antigens in the SC of the epidermis and are known to occur in all normal human sera. They have been shown by indirect immunofluorescence to be frequently associated with upper cytoplasmic (U-Cyt) antibodies. We have recently identified keratin intermediate filaments (KIF) as antigens for U-Cyt antibodies. In this study we investigated whether KIF also bear antigenic sites for SC antibodies. Normal human sera that contained SC and/or U-Cyt antibodies by indirect immunofluorescence were studied. Using immunoblot techniques 3 selected sera were shown to bind to high-molecular-weight (HMW) KIF proteins which had been extracted from 2 different epidermal cell preparations, that is, human callus or epidermis from which the SC had been removed by tapestripping. The 3 test sera were absorbed on KIF which had been reconstituted in vitro from urea extracts from both epidermal substrates. As shown by indirect immunofluorescence, the SC and U-Cyt antibodies of all 3 sera were absorbed out with KIF from callus and with KIF from epidermis without SC. Immunoblot experiments, which are more sensitive than indirect immunofluorescence, demonstrated the absorption of anti-KIF protein antibodies of the 3 test sera on callus KIF and 2 of the sera on KIF obtained from epidermis without SC. This was shown by the lack of staining of the respective HMW KIF proteins with the postabsorption sera. With the third serum a marked reduction of antibody binding was found after absorption on KIF from epidermis without SC. These data indicate that KIF bear antigenic sites for SC antibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATIN
KW  - CYTOPLASMIC filaments
KW  - CYTOPLASM
KW  - ANTIGENIC determinants
KW  - IMMUNOGLOBULINS
KW  - EPIDERMIS
N1  - Accession Number: 12261020; Hintner, Helmut 1 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May84, Vol. 82 Issue 5, p491; Subject Term: KERATIN; Subject Term: CYTOPLASMIC filaments; Subject Term: CYTOPLASM; Subject Term: ANTIGENIC determinants; Subject Term: IMMUNOGLOBULINS; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12261020
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12261020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - 
AU  - Aines, Andrew A.1
T1  - A Visit to the Wasteland of Federal Scientific and Technical Information Policy.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
J1  - Journal of the American Society for Information Science
PY  - 1984/05//
Y1  - 1984/05//
VL  - 35
IS  - 3
CP  - 3
M3  - Article
SP  - 179
EP  - 184
SN  - 00028231
AB  - Long before the appearance of the Reagan Administration, whose expressed policy was and is the reduction of the Federal Government in all areas save national security, there has been what is almost a precipitous retreat from overall planning and management of Federal scientific and technical information. The exodus got underway during the Nixon Administration in the early 1970s, a few years before the science apparatus was banished from the White House by a president who became disenchanted with scientists, if not science. The problem was that the stiff-necked men of science refused to bow down before the idols of political expediency. [ABSTRACT FROM AUTHOR]
KW  - Information policy
KW  - Federal regulation
KW  - Federal legislation
KW  - Communication policy
KW  - Economic policy
KW  - Scientists
N1  - Accession Number: 16795702; Authors: Aines, Andrew A. 1; Affiliations:  1: Scholar-in-Residence, National Library of Medicine, National Institutes of Health, Bethesda, MD 20209.; Subject: Information policy; Subject: Federal regulation; Subject: Federal legislation; Subject: Communication policy; Subject: Economic policy; Subject: Scientists; Number of Pages: 6p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
AU  - Wright, David E.
AU  - Horuk, Richard
AU  - Rodbell, Martin
T1  - Photoaffinity labeling of the glucagon receptor with a new glucagon analog.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/05/15/
VL  - 141
IS  - 1
M3  - Article
SP  - 63
EP  - 67
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The preparation, purification and characterization of Nϵ-4-azidophenylamidinoglucagon are described. This photoreactive peptide was found to be 50 % as potent as native glucagon in competing with 125I-labeled glucagon for binding to glucagon receptors on rat liver plasma membranes. Similarly, the analog was 50% as potent as native glucagon in its ability to stimulate adenylate cyclase. The photoreactive glucagon analog was radioiodinated to high specific activity with iodine-125 and was used to label rat liver plasma membrane proteins. Analysis of labeled membrane proteins by sodium dodecyl sulfate/polyacrylamide gel electrophoresis revealed covalent incorporation predominantly into a protein of relative molecular mass, Mr, of 50000-60000. Occasionally a protein of Mr 170000-180000 was also labeled. Irradiation of membranes in the presence of unlabeled glucagon or GTP selectively inhibited the labeling of the 50000-60000-Mr protein(s). As a result of these studies we suggest that the sodium-dodecyl-sulfate-dissociated glucagon receptor is a 50000-60000-Mr protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOTOAFFINITY labeling
KW  - GLUCAGON
KW  - LIVER
KW  - CELL membranes
KW  - PEPTIDE hormones
KW  - MEMBRANE proteins
N1  - Accession Number: 23563525; Wright, David E. 1 Horuk, Richard 1 Rodbell, Martin 1; Affiliation:  1: Laboratory of Cellular and Developmental Biology, National Institute of Arthritis, Diabeles and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.; Source Info: 5/15/84, Vol. 141 Issue 1, p63; Subject Term: PHOTOAFFINITY labeling; Subject Term: GLUCAGON; Subject Term: LIVER; Subject Term: CELL membranes; Subject Term: PEPTIDE hormones; Subject Term: MEMBRANE proteins; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Berman, Phyllis W.
AU  - Goodman, Vickie
T1  - Age and Sex Differences in Children's Responses to Babies: Effects of Adults' Caretaking Requests and Instructions.
JO  - Child Development
JF  - Child Development
Y1  - 1984/06//
VL  - 55
IS  - 3
M3  - Article
SP  - 1071
EP  - 1077
PB  - Wiley-Blackwell
SN  - 00093920
N1  - Accession Number: 12427540; Berman, Phyllis W. 1 Goodman, Vickie 2; Affiliation:  1: National Institute of Child Health and Human Development.  2: Florida State University.; Source Info: Jun1984, Vol. 55 Issue 3, p1071; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1467-8624.ep12427540
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaushal, Nuzhat A.
AU  - Hussain, Rabia
AU  - Ottesen, E. A.
T1  - Excretory-secretory and somatic antigens in the diagnosis of human filariasis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1984/06//
VL  - 56
IS  - 3
M3  - Article
SP  - 567
EP  - 576
PB  - Wiley-Blackwell
SN  - 00099104
AB  - In order to compare the immunodiognostic value of excretory-secretory (E-S) antigens derived from adult Brugia malayi worms with somatic antigens derived from adults, microfilariae (MO and infective larvae (L3) of these parasites, well defined serum pools from patients with filarial (brugia. bancrofti,, Ioa and perstans) and non-filarial (ascaris. stronglyoides, toxocara. echinococcus, cysticercus and schistosoma) helminth infections were tested against antigens derived from these different life cycle stages of B. malayi in a Staphylococcus aureus radioimmunoprecipitation assay (5. aureus RIA). The adult brugia antigens proved significantly more discriminatory than those of the other parasite stages, with the homologous brugia serum pool also showing greater reactivity to adult than to L3 and Mf antigens. Similar results were obtained when individual sera from patients (rather than serum pools) were tested in the same assay. The most surprising finding was the minimal reactivity seen between the adult filarial antigens and the non-filarial serum pools despite the presence in these pools of strong antibody reactivity with their homologous antigens. The reasons underlying the unexpected specificity of this S, aureus RIA for discriminating among sera from filarial and non-filarial infections were analysed qualitatively by immunoprecipitation techniques. It was found that use of the chloramine- T method for radioiodination resulted in preferential labelling of the low molecular weight (mol. wt) proteins (10-70.000 daltons) in the B. malayi adult somatic antigen and that these antigens were bound primarily by the filarial and not the non-filarial serum pools. These findings suggest that lower mol. wt helminth antigens may show greater species specificity than those with higher mol. wt, and those with higher mol. wt. greater cross-reactivity. If substantiated by further analysis, such results would have important implications for the subsequent isolation of diagnostically important filarial parasite antigens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXCRETION
KW  - FILARIASIS
KW  - DIAGNOSIS
KW  - SOMATIC hybrids
KW  - ECHINOCOCCUS
KW  - STAPHYLOCOCCUS aureus
KW  - E-S antigen
KW  - filariasis
KW  - human
KW  - immunodiagnosis
N1  - Accession Number: 16247536; Kaushal, Nuzhat A. 1 Hussain, Rabia 1 Ottesen, E. A. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jun1984, Vol. 56 Issue 3, p567; Subject Term: EXCRETION; Subject Term: FILARIASIS; Subject Term: DIAGNOSIS; Subject Term: SOMATIC hybrids; Subject Term: ECHINOCOCCUS; Subject Term: STAPHYLOCOCCUS aureus; Author-Supplied Keyword: E-S antigen; Author-Supplied Keyword: filariasis; Author-Supplied Keyword: human; Author-Supplied Keyword: immunodiagnosis; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Coomes, Marguerite Wilton
AU  - Sparks, Rebecca W.
AU  - Fouts, James R.
T1  - Oxidation of 7-Ethoxycoumarin and Conjugation of Umbelliferone by Intact, Viable Epidermal Cells from the Hairless Mouse.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/06//
VL  - 82
IS  - 6
M3  - Article
SP  - 598
EP  - 601
SN  - 0022202X
AB  - Intact, viable (>80%) epidermal cells were isolated from the hairless mouse. These cells metabolized 7-ethoxycoumarin (7-EC) to umbelliferone (UMB) (3 pmol/min/106 cells) and UMB to the sulfate and glucuronide conjugates (1 pmol/min/106 cells). The rate of oxidation in intact cells compared well with that in disrupted cells with added NADPH, but conjugation proceeded more rapidly in disrupted cells with added cofactors, due to a combination of "activation" of the UDP-glucuronosyltransferase, and to a limitation of activity by the concentration of UDP-glucuronic acid in the intact cells. Pretreatment of the animals with 5,6-benzoflavone resulted in a 5-fold increase in the rate of oxidation, and a 2-fold increase in both the rate of conjugation and the intracellular concentration of UDP-glucuronic acid. UDP-glucuronic acid concentration in isolated cells increased during incubation with glucose, and was regenerated to a steady-state concentration on incubation of cells with UMB. Pretreatment of animals with 5,6-benzoflavone decreased the percentage of metabolite conjugated (from 30% to 15%), whereas adding an inhibitor of oxidation, ellipticine, to cells isolated from pretreated animals, increased the percentage of metabolite conjugated (from 15% to 40%). Sulfation of UMB was almost undetectable, except at very low concentrations (<10 nm) of substrate. Thus, glucuronidation of UMB in epidermal cells may be limited by UDP-glucuronic acid availability; sulfation in the epidermis may contribute little to the conjugation of UMB; and >70% of the products of 7-EC oxidation in the skin may remain unconjugated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - EPIDERMIS
KW  - MICE as laboratory animals
KW  - GLUCOSE
KW  - OXIDATION
KW  - EPITHELIUM
KW  - CHEMICAL inhibitors
KW  - SKIN
N1  - Accession Number: 12261390; Coomes, Marguerite Wilton 1 Sparks, Rebecca W. 1 Fouts, James R. 1; Affiliation:  1: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, U.S.A.; Source Info: Jun84, Vol. 82 Issue 6, p598; Subject Term: CELLS; Subject Term: EPIDERMIS; Subject Term: MICE as laboratory animals; Subject Term: GLUCOSE; Subject Term: OXIDATION; Subject Term: EPITHELIUM; Subject Term: CHEMICAL inhibitors; Subject Term: SKIN; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12261390
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DiGiovanna, John J.
AU  - Gross, Earl G.
AU  - McClean, Sharon W.
AU  - Ruddel, Mark E.
AU  - Gantt, Gail
AU  - Peck, Gary L.
T1  - Etretinate: Effect of Milk Intake on Absorption.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/06//
VL  - 82
IS  - 6
M3  - Article
SP  - 636
EP  - 640
SN  - 0022202X
AB  - Since etretinate, an aromatic retinoid useful in the treatment of psoriasis and other skin disorders is lipid-soluble, it may be poorly absorbed in the absence of a fat load. We therefore studied serum concentrations of etretinate and its major metabolite (Ro 10-1670) after the controlled administration of etretinate. After an overnight fast, 6 Darier's disease and 4 psoriatic patients received a 1 mg/kg morning dose of etretinate with water or 1 pint of whole milk (fat load). There was a 260% increase (p < 0.0005) in the mean of each patient's increase in the baseline-corrected peak serum concentration of etretinate after administration with milk (115 ± 15 μg/dl) compared to after administration with water (32 ± 4 μg/dl). Over a 24-h period there was an overall 296 ± 26% (p < 0.0005) increase in serum etretinate after administration with milk compared to water in 5 patients with Darier's disease. In contrast to the serum etretinate, there was a 17% mean decrease (p < 0.025) in the corrected peak serum concentration of Ro 10-1670 in all 10 patients after administration of etretinate with milk compared to water. The net result of these alterations is that the mean corrected serum concentration of etretinate is higher than Ro 10-1670 at all time points measured after milk administration. In contrast, after administration of etretinate with water the major retinoid in the serum is Ro 10-1670. Establishing the clinical significance of these alterations may require controlled clinical trials. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ETRETINATE
KW  - RETINOIDS
KW  - PSORIASIS
KW  - SKIN diseases
KW  - SERUM
KW  - KERATOSIS follicularis
KW  - PATIENTS
KW  - CLINICAL trials
N1  - Accession Number: 12261476; DiGiovanna, John J. 1 Gross, Earl G. 1 McClean, Sharon W. 2 Ruddel, Mark E. 2 Gantt, Gail 1 Peck, Gary L. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Clinical Chemistry, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun84, Vol. 82 Issue 6, p636; Subject Term: ETRETINATE; Subject Term: RETINOIDS; Subject Term: PSORIASIS; Subject Term: SKIN diseases; Subject Term: SERUM; Subject Term: KERATOSIS follicularis; Subject Term: PATIENTS; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12261476
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Emilson, C. G.
AU  - Nilsson, B.
AU  - Bowen, W. H.
T1  - Carbohydrate composition of dental plaque from primates with irradiation caries.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1984/06//
VL  - 13
IS  - 3
M3  - Article
SP  - 213
EP  - 220
SN  - 03009777
AB  - Carbohydrate analyses were performed on dental plaque collected from the teeth of irradiated monkeys, non-irradiated monkeys and a group of Streptociccus mutans free animals, all of which were fed the same standard cariogenic diet. Glucose was the predominant sugar constituent in plaque and was detected in highest concentration in the irradiated animals. Small amounts of pentoses and other hexoses were also present. Plaque from irradiated animals contained, by comparison with the other groups, higher levels of Strep mutans and lower levels of Streptococcus sanguis and Actinomyees. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARBOHYDRATES
KW  - DENTAL plaque
KW  - GLUCOSE
KW  - DIET
KW  - PENTOSES
KW  - MONKEYS
N1  - Accession Number: 11504347; Emilson, C. G. 1 Nilsson, B. 2 Bowen, W. H. 1; Affiliation:  1: National Caries  Program, National  Institute of Dental Research, Bethesda, Maryland, U.S.A.  2: National Cancer Institute, National  Institute s of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun84, Vol. 13 Issue 3, p213; Subject Term: CARBOHYDRATES; Subject Term: DENTAL plaque; Subject Term: GLUCOSE; Subject Term: DIET; Subject Term: PENTOSES; Subject Term: MONKEYS; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1600-0714.ep11504347
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Campbell, Arthur A.
T1  - Determinants of Fertility in Developing Countries.
JO  - Population & Development Review
JF  - Population & Development Review
Y1  - 1984/06//
VL  - 10
IS  - 2
M3  - Book Review
SP  - 371
EP  - 373
SN  - 00987921
AB  - Reviews the book "Determinants of Fertility in Developing Countries," edited by Rodolfo A. Bulatao and Ronald D. Lee.
KW  - FERTILITY
KW  - NONFICTION
KW  - BULATAO, Rodolfo A.
KW  - LEE, Ronald D.
KW  - DETERMINANTS of Fertility in Developing Countries (Book)
N1  - Accession Number: 16667334; Campbell, Arthur A. 1; Affiliations: 1: Center for Population Research National Institute of Child Health and Human Development National Institutes of Health; Issue Info: Jun1984, Vol. 10 Issue 2, p371; Subject Term: FERTILITY; Subject Term: NONFICTION; Reviews & Products: DETERMINANTS of Fertility in Developing Countries (Book); People: BULATAO, Rodolfo A.; People: LEE, Ronald D.; Number of Pages: 3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Ayala, F.
AU  - Balato, N.
AU  - Cefarano, S.
AU  - Castellot, G.
T1  - Immunochemical characterization of the abnormal paraprotein in a case of scleromyxoedema.
JO  - Clinical & Experimental Dermatology
JF  - Clinical & Experimental Dermatology
Y1  - 1984/07//
VL  - 9
IS  - 4
M3  - Article
SP  - 351
EP  - 357
SN  - 03076938
AB  - The monoclonal paraprotein from the serum of a patient with scleromyxoedema was characterized as IgG-λ class. No abnormalities involving antigenic properties of the Fab, Fc, and Fd portions of the molecule were observed. In order to examine the paraprotein thoroughly, IgG was isolated from the serum by a standard procedure that unexpectedly induced an inexplicable cleavage of the molecule and evidenced an unusual hidden Fc deficiency of monoclonal protein. The hypothesis about significant structural abnormalities of this seleromyxoedema paraprotein was supported by its sedimentation coefficient (S[SUB20,w] = 6.41) and molecular weight (104,000 daltons). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PARAPROTEINEMIA
KW  - BLOOD protein disorders
KW  - MOLECULES
KW  - IMMUNOGLOBULIN G
KW  - MONOCLONAL antibodies
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 11678174; Ayala, F. 1; Balato, N. 1; Cefarano, S. 2; Castellot, G. 2; Source Information: Jul84, Vol. 9 Issue 4, p351; Subject: PARAPROTEINEMIA; Subject: BLOOD protein disorders; Subject: MOLECULES; Subject: IMMUNOGLOBULIN G; Subject: MONOCLONAL antibodies; Subject: IMMUNOGLOBULINS; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1365-2230.ep11678174
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Gerrard, Theresa L.
AU  - Jurgensen, Cynthia H.
AU  - Fauci, A. S.
T1  - Modulation of human B cell responses by a monoclonal antibody to an activation antigen 4F2.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1984/07//
VL  - 57
IS  - 1
M3  - Article
SP  - 155
EP  - 162
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Antigen specific human antibody responses can be modulated in vitro by the addition of 4F2 antibody, a monoclonal antibody (MoAb) which recognizes an antigen on activated T cells and B ceils. Specific antibody responses induced with the antigen are suppressed by the addition of 4F2. However, specific antibody responses induced with the polyclonal activator, pokeweed mitogen (PWM), are significantly enhanced by the addition or 4F2. Proliferative responses to both antigen and PWM are suppressed by the addition of 4F2. The enhancement of PWM stimulated responses by 4F2 is mediated by T cells. However, in the absence of T cells. 4F2 can directly inhibit antigen specific B cells. Polyclonal Ig production stimulated by PWM was also enhanced by 4F2. Thus, the immunomodulating effects of the 4F2 MoAb are the result of a balance of enhancement and suppression mediated at the T cell and the B cell level, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - T cells
KW  - B cells
KW  - LYMPHOCYTES
KW  - IMMUNOGLOBULINS
KW  - ANTIGENS
KW  - 4F2
KW  - activation antigcn
KW  - B cell responses
KW  - monoclonal antibodies
N1  - Accession Number: 17561826; Gerrard, Theresa L. 1 Jurgensen, Cynthia H. 1 Fauci, A. S. 1; Affiliation:  1: Laboratory of immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jul1984, Vol. 57 Issue 1, p155; Subject Term: MONOCLONAL antibodies; Subject Term: T cells; Subject Term: B cells; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Author-Supplied Keyword: 4F2; Author-Supplied Keyword: activation antigcn; Author-Supplied Keyword: B cell responses; Author-Supplied Keyword: monoclonal antibodies; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fine, Jo-David
AU  - Smith, Lynne T.
AU  - Holbrook, Karen A.
AU  - Katz, Stephen I.
T1  - The Appearance of Four Basement Membrane Zone Antigens in Developing Human Fetal Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/07//
VL  - 83
IS  - 1
M3  - Article
SP  - 66
EP  - 69
SN  - 0022202X
AB  - In order to study the ontogeny of various structural and antigenic components of the basement membrane zone of human skin, we have examined skin specimens from 20 aborted fetuses ranging in gestational ages from 6 to 25 weeks, utilizing light microscopy, transmission electron microscopy, and indirect immunofluorescence with antibodies to bullous pemphigoid antigen, laminin, type IV collagen, and to the antigen defined by KF-1 monoclonal antibody. Both laminin and type IV collagen were detectable as early as 6 weeks of gestational age. In contrast, bullous pemphigoid antigen and the antigen defined by KF- 1 antibody were not detectable before 10 weeks and 16 weeks, respectively. The appearance of bullous pemphigoid antigen correlated with stratification of the epidermis and the formation of hemidesmosomes and anchoring fibrils at the basement membrane zone. KF- 1 antigen is first expressed when the epidermis is further stratified, hemidesmosomes and anchoring fibrils are present in greater numbers and with increased frequency at the dermal-epidermal junction, and hair follicles have begun to bud downward from the basal layer of the epidermis. Our findings suggest an orderly sequence to the appearance of these basement membrane zone components within human skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ONTOGENY
KW  - EMBRYOLOGY
KW  - ANTIGENS
KW  - IMMUNITY
KW  - GESTATIONAL age
KW  - ELECTRON microscopy
N1  - Accession Number: 12261707; Fine, Jo-David 1 Smith, Lynne T. 2,3 Holbrook, Karen A. 2,3 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington, U.S.A.  3: Department of  Medicine (Dermatology), University of Washington School of Medicine, Seattle, Washington, U.S.A.; Source Info: Jul84, Vol. 83 Issue 1, p66; Subject Term: ONTOGENY; Subject Term: EMBRYOLOGY; Subject Term: ANTIGENS; Subject Term: IMMUNITY; Subject Term: GESTATIONAL age; Subject Term: ELECTRON microscopy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12261707
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Breathnach, Stephen M.
AU  - Katz, Stephen I.
T1  - Thy-1+ Dendritic Cells in Murine Epidermis Are Bone Marrow-Derived.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/07//
VL  - 83
IS  - 1
M3  - Article
SP  - 74
EP  - 77
SN  - 0022202X
AB  - Thy-1+ Ly-5+ dendritic cells have recently been described as a resident cell population in murine epidermis, but their ontogeny and function are unknown. We therefore investigated the origin and turnover of epidermal Thy- 1+ cells utilizing chimeric mice. Lethally x- irradiated AKR/J (Thy-1.1+) and AKR/Cum (Thy-1.2+ mice were reconstituted with allogeneic bone marrow cells with or without thymocytes from congenic AKR/ Cum or AKR/J mice, respectively. The density of residual indigenous Thy-1.1+ cells in AKR/J chimeras and Thy-1.2+ cells in AKR/Cum chimeras was substantially reduced following x-irradiation, as determined by immunofluorescence staining of epidermal sheets. Epidermal repopulation by allogeneic Thy-1+ dendritic epidermal cells was first observed at 5 weeks in AKR/J chimeras and at 7 weeks in AKR/Cum chimeras and progressed slowly. Repopulation was not enhanced by increasing the number of allogeneic bone marrow cells injected from 2 × 107 to 108 cells or by the addition of 8 x 107 allogeneic thymocytes to the donor inoculate. Epidermal repopulation by allogeneic Thy-1.2+ cells was not seen in AKR/J mice reconstituted with syngeneic bone marrow cells and allogeneic Thy-1.2+ AKR/Cum thymocytes. Taken together, these results indicate that Thy-1+ dendritic epidermal cells are derived from the bone marrow and suggest that they are not related to conventional peripheral T-lymphocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENDRITIC cells
KW  - EPIDERMIS
KW  - ONTOGENY
KW  - BONE marrow
KW  - IMMUNE system
KW  - IRRADIATION
N1  - Accession Number: 12261808; Breathnach, Stephen M. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul84, Vol. 83 Issue 1, p74; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS; Subject Term: ONTOGENY; Subject Term: BONE marrow; Subject Term: IMMUNE system; Subject Term: IRRADIATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12261808
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - 
AU  - Bernstein, Lionel M.1
AU  - Williamson, Robert E.1
T1  - Testing of a Natural Language Retrieval System for a Full Text Knowledge Base.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
J1  - Journal of the American Society for Information Science
PY  - 1984/07//
Y1  - 1984/07//
VL  - 35
IS  - 4
CP  - 4
M3  - Article
SP  - 235
EP  - 247
SN  - 00028231
AB  - "A Navigator of Natural Language Organized Data" (ANNOD) is a retrieval system which combines use of probabilistic, linguistic, and empirical means to rank individual paragraphs of full text for their similarity to natural language queries proposed by users. ANNOD includes common word deletion, word root isolation, query expansion by a thesaurus, and application of a complex empirical matching (ranking) algorithm. The Hepatitis Knowledge Base, the text of a prototype information system, was the file used for testing ANNOD. Responses to a series of users' unrestricted natural language queries were evaluated by three testers. Information needed to answer 85 to 95% of the queries was located and displayed in the first few selected paragraphs. It was successful in locating information in both the classified (listed in Table of Contents) and unclassified portions of text. Development of this retrieval system resulted from the complementarity of and interaction between computer science and medical domain expert knowledge. Extension of these techniques to larger knowledge bases is needed to clarify their proper role. [ABSTRACT FROM AUTHOR]
KW  - Natural language processing (Computer science)
KW  - Text files
KW  - Algorithms
KW  - Information storage & retrieval systems
KW  - Expansion (Business)
KW  - Technology
N1  - Accession Number: 16801368; Authors: Bernstein, Lionel M. 1; Williamson, Robert E. 1; Affiliations:  1: Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, MD 20209; Subject: Natural language processing (Computer science); Subject: Text files; Subject: Algorithms; Subject: Information storage & retrieval systems; Subject: Expansion (Business); Subject: Technology; Number of Pages: 13p; Record Type: Article
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DP  - EBSCOhost
DB  - lls
ER  - 

TY  - JOUR
AU  - Nakabayashi, Yasuharu
AU  - Dvoretzky, Israel
AU  - Chattopadhyay, Sisir K.
AU  - Lowy, Douglas R.
T1  - In Vitro Transformation by Bovine Papillomavirus.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/07/15/Jul84 Supplement
VL  - 83
M3  - Article
SP  - 12s
EP  - 17s
SN  - 0022202X
AB  - We have studied tumorigenic transformation of mouse tissue culture cells by bovine papillomavirus (BPV) as a model of papillomavirus-induced cell proliferation. When BPV or its 7.9-kb full-length viral DNA genome induces focal transformation of mouse calls, the viral DNA is maintained in the transformed cells as multiple extrachromosomal copies. The transforming capacity was initially localized to a 69% subgenomic fragment of the viral DNA genome. We have further characterized the BPV DNA sequences that can encode the transforming function by generating and analyzing the transforming activity of a series of BPV DNA deletion mutants. The results indicated that two discontinuous segments of the viral DNA are required for transformation. One segment, near the 5' end of the 69% transforming fragment, probably represents a control element of the viral DNA. The second segment, which lies within the 3' end of the 69% fragment, encodes transforming sequences of the viral DNA. A retroviral control element (the long terminal repeat DNA of Harvey murine sarcoma virus) will activate the 2.3-kb segment at the 3' end of the 69% fragment to transform the mouse cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PAPILLOMAVIRUSES
KW  - ONCOGENIC viruses
KW  - CELL proliferation
KW  - GENOMES
KW  - NUCLEOTIDE sequence
KW  - DNA
N1  - Accession Number: 12281119; Nakabayashi, Yasuharu 1 Dvoretzky, Israel 1 Chattopadhyay, Sisir K. 1 Lowy, Douglas R. 1; Affiliation:  1: Dermatology Brunch and Laboratory of Cellular Oncology, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul84 Supplement, Vol. 83, p12s; Subject Term: PAPILLOMAVIRUSES; Subject Term: ONCOGENIC viruses; Subject Term: CELL proliferation; Subject Term: GENOMES; Subject Term: NUCLEOTIDE sequence; Subject Term: DNA; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12281119
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Franchini, G.
AU  - Wong-Staal, F.
AU  - Gallo, R. C.
T1  - Molecular Studies of Human T-Cell Leukemia Virus and Adult T-Cell Leukemia.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/07/15/Jul84 Supplement
VL  - 83
M3  - Article
SP  - 63s
EP  - 66s
SN  - 0022202X
AB  - We describe previously published work as well as new data on the molecular biology of human T-cell leukemia virus (HTLV) and its associated disease, adult T-cell leukemia-lymphoma (ATLL). This specific kind of disease is endemic to certain areas of Japan and the Caribbean, and several isolated cases have been described also in the United States, Israel, South America, and Africa. The disease is probably also endemic to Africa and South America, but sufficient studies of these areas have not been performed. We have molecularly cloned the HTLV genome and used the viral DNA as a probe in a large molecular study of the DNAs of human hematopoietic malignancies. The results showed that HTLV sequences could be detected in the fresh leukemic cells of all cases of ATLL tested. The neoplastic cells are of clonal origin and contain one or few copies of integrated HTLV. Detailed comparative analyses by restriction enzyme mapping of the proviral DNA in U.S., Japanese, Caribbean, and Israeli cases revealed that the viruses are almost indistinguishable. The DNA from neoplastic cells of other cases of hematopoietic neoplasias analyzed were negative for HTLV sequences with the exception of two. DNA from cells of a patient (MO) with a T-cell variant of hairy cell leukemia did contain a provirus only distantly related to HTLV (less than 10% of DNA sequence homology). The virus isolated from the MO cells has been designated HTLV-II. The second case was a patient with chronic myeloid leukemia whose cells contained exogenous DNA sequences distantly related to HTLV. Different fragments of the clones HTLV genome have been used to hybridize to DNA from uninfected normal tissues of several vertebrate species, including humans, in a search for cell-derived sequences related to the HTLV genome. No homologous sequences were found except sequences distantly related to the <em>pol</em> and <em>env</em> genes, indicating that HTLV does not carry a cellularly derived <em>one</em> gene. Surprisingly, however, infection of normal human fresh T cells by HTLV transforms them into cells with permanent growth and with several other properties similar to neoplastic T cells. We have also studied the expression of viral and cellular genes in fresh and cultured neoplastic cells from patients with ATLL. Several species of viral mRNAs are always detected in the cultured neoplastic cells, whereas in some fresh samples expression of normal mRNA was not detected.  The lack of viral mRNA in some of the fresh sample suggested that the neoplastic transformation could be maintained without the expression of viral genes.  Because T cells of patients with ATLL as well as cells transformed in vitro by HTLV do have a decreased or no requirement for T-cell growth factor (TCGF; IL-2) for growth in vitro and exhibit a high number of TCGF cell surface receptors, we hypothesized that HTLV infection may involve the transcriptional activation of the TCGF gene concomitant with TCGF-induced persistent cell proliferation.  However, only low-level expression of the TCGF gene was found in 2 or 5 cell lines and in none of the two fresh samples. Thus autostimulation by TCGF of one cell interacting with its own receptor cannot be the mechanism for initiation or maintenance of the abnormal growth induced by HTLV. We also analyzed the RNAs of the HTLV-infected cells for the expression of various <em>one</em> genes.  None of the <em>one</em> genes tested seemed to be transcriptionally activated int eh fresh leukemic cells, with the exception of the <em>sis</em> gene, which is expressed at high level in two neoplastic cell lines (HUT 102 and MO) infected with HTLV-I and HTLV-II, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HTLV (Viruses)
KW  - MOLECULAR biology
KW  - GENOMES
KW  - DNA viruses
KW  - LEUKEMIC reticuloendotheliosis
KW  - ADULT T-cell leukemia
N1  - Accession Number: 12281191; Franchini, G. 1 Wong-Staal, F. 1 Gallo, R. C. 1; Affiliation:  1: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul84 Supplement, Vol. 83, p63s; Subject Term: HTLV (Viruses); Subject Term: MOLECULAR biology; Subject Term: GENOMES; Subject Term: DNA viruses; Subject Term: LEUKEMIC reticuloendotheliosis; Subject Term: ADULT T-cell leukemia; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12281191
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Herberman, Ronald B.
T1  - Possible Role of Natural Killer Cells and Other Effector Cells in Immune Surveillance Against Cancer.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1984/07/15/Jul84 Supplement
VL  - 83
M3  - Article
SP  - 137s
EP  - 140s
SN  - 0022202X
AB  - The concept of immune surveillance against cancer was initially formulated with thymus-dependent immunity as a central and requisite effector mechanism. However, a substantial amount of evidence has accumulated to indicate that T cell-mediated immunity is mainly important for protection against tumors induced by oncogenic viruses and not for many other types of spontaneous or chemical carcinogen-induced tumors. It now appears likely that various components of the natural immune system also play major roles in immune surveillance. These include natural killer (NK) cells and macrophages. The existing evidence for the roles of these effector cells is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KILLER cells
KW  - CANCER
KW  - THYMUS
KW  - T cells
KW  - IMMUNITY
KW  - TUMORS
KW  - ONCOGENIC viruses
KW  - MACROPHAGES
N1  - Accession Number: 12282012; Herberman, Ronald B. 1; Affiliation:  1: Biological Therapeutics Branch, National Cancer Institute, Frederick, Maryland, U.S.A.; Source Info: Jul84 Supplement, Vol. 83, p137s; Subject Term: KILLER cells; Subject Term: CANCER; Subject Term: THYMUS; Subject Term: T cells; Subject Term: IMMUNITY; Subject Term: TUMORS; Subject Term: ONCOGENIC viruses; Subject Term: MACROPHAGES; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12282012
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westerhoff, Hans V.
AU  - Yi-Der Chen
T1  - How do enzyme activities control metabolite concentrations?
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/07/16/
VL  - 142
IS  - 2
M3  - Article
SP  - 425
EP  - 430
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A simple theorem is derived relating the extent to which enzymes in a metabolic pathway control the steady-state concentration of metabolites to the kinetic properties of those enzymes. The theorem gives insight into the mechanism by which the concentration of a second messenger is controlled by the enzymes that form and degrade it, and provides an alternative to the ‘cross-over theorem’. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENZYMES
KW  - PROTEINS
KW  - METABOLITES
KW  - BIOMOLECULES
KW  - METABOLISM
KW  - ENZYMOLOGY
KW  - BIOCHEMISTRY
N1  - Accession Number: 13852518; Westerhoff, Hans V. 1 Yi-Der Chen 1; Affiliation:  1: Laboratory of Biochemistry, B. C. P. Jansen Instituut, University of Amsterdam; and Laboratory of Molecular Biology, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; Source Info: 7/16/84, Vol. 142 Issue 2, p425; Subject Term: ENZYMES; Subject Term: PROTEINS; Subject Term: METABOLITES; Subject Term: BIOMOLECULES; Subject Term: METABOLISM; Subject Term: ENZYMOLOGY; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hanson, R. G.
AU  - Hoofnagle, J. H.
AU  - Minuk, G. Y.
AU  - Purcell, R. H.
AU  - Gerin, J. L.
T1  - Cell-mediated immunity to hepatitis B surface antigen in man.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1984/08//
VL  - 57
IS  - 2
M3  - Article
SP  - 257
EP  - 264
PB  - Wiley-Blackwell
SN  - 00099104
AB  - An aqueous preparation of hepatitis B virus (HBV) vaccine was used as an intradermal skin lest antigen to assess delayed hypersensitivity to hepatitis B surface antigen (HBsAg). Thirty-five persons were tested including 10 individuals seronegative for all HBV markers. 10 positive for HBsAg (chronic carriers) and 15 positive for antibody to HBsAg (anti-HBs), five of whom had received the HBV vaccine. Ali patients were also studied for lymphocyte blastogenic responses to phytohaemagglutinin, concanavalin A, pokeweed mitogen and purified HBsAg. Only one individual had a positive delayed skin test reaction to HBsAg. This person had received the HBV vaccine and had high titres of anti-HBs in serum. However, neither this individual nor any other subject exhibited a positive lymphocyte blastogenic response to HBsAg in vitro. Thus, delayed hypersensitivity skin test reactivity to HBsAg was not detected after natural infection with HBV and was rarely present in hyperimmunized individuals. In vitro assays of immune responsiveness failed to demonstrate cellular immunity to HBsAg even in hyperimmunized persons. These studies provide no evidence that cell-mediated immunity to HBsAg plays a role in the immunopathogenesis of acute or chronic type B hepatitis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS B
KW  - IMMUNITY
KW  - VACCINES
KW  - ANTI-idiotypic vaccines
KW  - IMMUNOGLOBULINS
KW  - LIVER diseases
KW  - hepatitis B surface antigen chronic hepatitis hepatitis B virus vaccine delayed hypersensitivity
N1  - Accession Number: 15939834; Hanson, R. G. 1 Hoofnagle, J. H. 1 Minuk, G. Y. 1 Purcell, R. H. 2 Gerin, J. L. 1; Affiliation:  1: Liver Diseases Section, Digestive Diseases Branch, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases.  2: Hepatitis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda and Molecular Virology and Immunology Division, Georgetown University, Rockville, Maryland, USA.; Source Info: Aug1984, Vol. 57 Issue 2, p257; Subject Term: HEPATITIS B; Subject Term: IMMUNITY; Subject Term: VACCINES; Subject Term: ANTI-idiotypic vaccines; Subject Term: IMMUNOGLOBULINS; Subject Term: LIVER diseases; Author-Supplied Keyword: hepatitis B surface antigen chronic hepatitis hepatitis B virus vaccine delayed hypersensitivity; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Curtis, J. L.
AU  - Nordin, A. A.
T1  - Primary <em>in vitro</em> plaque-forming cell response to DAGG-Ficoll: LPS-induced enhancement mediated by interleukin-1.
JO  - Immunology
JF  - Immunology
Y1  - 1984/08//
VL  - 52
IS  - 4
M3  - Article
SP  - 711
EP  - 719
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The specific primary in vitro plaque-forming cell (PFC) response of C57B1/6 nu/nu spleen cells to the Type 2 T-independent (TI-2) antigen DAGG-Ficoll was analysed in the absence of T cell help in a serum-free medium. Lipopolysaccharide (LPS) enhancement of the antigen-specific response was shown to be mediated by soluble factors contained in the supernatants of LPS-induced bone marrow-derived macrophages. The activity of these supernatants was not associated with residual LPS, since the antigenspecific response of B cells from mice genetically deficient in LPS receptors was equally well enhanced. The activity of these supernatants was associated with interleukin-1 (IL-1) and partially purified IL-1 prepared from P388D1 cells also enhanced the primary in vitro response to DAGG-Ficoll. Limiting dilution analysis experiments showed that only in the presence of exogenously added IL-1 could a single cell type, presumably the B cells, be shown to be limiting. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - INTERLEUKIN-1
KW  - ENDOTOXINS
KW  - MACROPHAGES
KW  - B cells
KW  - ANTIGENS
N1  - Accession Number: 13947805; Curtis, J. L. 1 Nordin, A. A. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center National Institute on Aging, National Institutes of Health, PHS, U. S. Department of Health and Human Services, Bethesda and Baltimore City Hospitals, Baltimore, Maryland, U.S.A.; Source Info: Aug84, Vol. 52 Issue 4, p711; Subject Term: T cells; Subject Term: INTERLEUKIN-1; Subject Term: ENDOTOXINS; Subject Term: MACROPHAGES; Subject Term: B cells; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costa, Jr., Paul T.
AU  - McCrae, Robert R.
AU  - Holland, JohnL.
T1  - Personality and Vocational Interests in an Adult Sample.
JO  - Journal of Applied Psychology
JF  - Journal of Applied Psychology
Y1  - 1984/08//
VL  - 69
IS  - 3
M3  - Article
SP  - 390
EP  - 400
SN  - 00219010
AB  - This article examines the relations between Holland's vocational typology and the Neuroticism-Extraversion-Openness (NEO) model of personality in a sample of men (N = 217) and women (N = 144) aged 21 to 89. Young and old adult groups were similar to college students in most vocational interests, and the same pattern of sex differences was found. Correlations between Self-Directed Search (SDS) scales and NEO scores showed strong associations of Investigative and Artistic interests with Openness to Experience, and of Social and Enterprising interests with Extraversion. Individuals interested primarily in Conventional occupations tended to be closed to experience. These associations were generally confirmed when spouse ratings were used as a non-self-report measure of personality traits in a subset of the subjects. The NEO complements the Holland typology, primarily in providing measures of Neuroticism. Research on the possible utility of supplementing vocational interest data with personality measures is suggested, and some implications for vocational counseling among older adults are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Applied Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY & occupation
KW  - VOCATIONAL interests
KW  - OCCUPATIONS
KW  - VOCATIONAL guidance
KW  - PERSONALITY
KW  - PSYCHOLOGY
KW  - EDUCATION, TRAINING, AND CAREER DEVELOPMENT
N1  - Accession Number: 6239338; Costa, Jr., Paul T. 1; McCrae, Robert R. 1; Holland, JohnL. 2; Affiliations: 1: Gerontology Research Center, National Institute on Aging, National Institutes of Health.; 2: Johns Hopkins University.; Issue Info: Aug84, Vol. 69 Issue 3, p390; Thesaurus Term: PERSONALITY & occupation; Thesaurus Term: VOCATIONAL interests; Thesaurus Term: OCCUPATIONS; Thesaurus Term: VOCATIONAL guidance; Subject Term: PERSONALITY; Subject Term: PSYCHOLOGY; Author-Supplied Keyword: EDUCATION, TRAINING, AND CAREER DEVELOPMENT; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 11p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Schoenberg, Ronald
AU  - Richtand, Carol
T1  - Application of the EM Method.
JO  - Sociological Methods & Research
JF  - Sociological Methods & Research
Y1  - 1984/08//
VL  - 13
IS  - 1
M3  - Article
SP  - 127
SN  - 00491241
AB  - The article studies the application of the estimation-maximization (EM) algorithm to provide maximum likelihood of the parameters of multiple indicator/factor analysis models. Current methods for the maximum likelihood estimation of multiple indicator measurement models and factor analysis models are quite complicated given that they involve the calculation of first-and second-order partial derivatives of the maximum likelihood function as well as a very sophisticated iterative method. It is computationally simpler than the currently used methods-first- and second-order partial derivatives are not calculated, nor is the calculation of the function itself necessary-and computer programs that implement the EM method require considerably less storage, far fewer instructions, and less precision than the usual methods. The computational burden is so reduced that microcomputers may be programmed to estimate measurement models that at one time taxed the resources of the CDC 6400. If the final maximum likelihood estimates of the parameters were used in the computation of the values of the latent variables, then the estimates of the latent variables would be regression method factor scores.
KW  - ALGORITHMS
KW  - ESTIMATION theory
KW  - VARIABLES (Mathematics)
KW  - LATENT structure analysis
KW  - CORRELATION (Statistics)
KW  - FACTOR analysis
KW  - PATH analysis (Statistics)
N1  - Accession Number: 5819142; Schoenberg, Ronald 1; Richtand, Carol 2; Source Information: Aug84, Vol. 13 Issue 1, p127; Subject: ALGORITHMS; Subject: ESTIMATION theory; Subject: VARIABLES (Mathematics); Subject: LATENT structure analysis; Subject: CORRELATION (Statistics); Subject: FACTOR analysis; Subject: PATH analysis (Statistics); Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 2006-06415-036
AN  - 2006-06415-036
AU  - Hadley, Suzanne W.
T1  - Major and Not so Major Therapies.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1984/08//
VL  - 29
IS  - 8
SP  - 662
EP  - 663
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06415-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hadley, Suzanne W.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychotherapeutic Techniques; Psychotherapy. Minor Descriptor: Therapeutic Processes. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Hariman, Jusuf (Ed). The Therapeutic Efficacy of the Major Psychotherapeutic Techniques=Springfield, IL: Charles C. Thomas, 1983. 368 pp. $33.50; 1983. Page Count: 2. Issue Publication Date: Aug, 1984. 
AB  - Reviews the book, The Therapeutic Efficacy of the Major Psychotherapeutic Techniques by Jusuf Hariman (Ed.) (1983). The overall value of an edited volume depends in large part on the composition of the collected articles or chapters. This volume is a disappointment. Two limitations are particularly evident. First, although the implicit claims for the volume are noteworthy, the scope of the collection is limited and subject to serious question. The second major limitation is the volume's failure to achieve its stated purposes. This volume is perhaps best seen as a catalogue of widely varying, frequently esoteric approaches to psychotherapy. It reveals the extraordinary range of treatment techniques, it reveals the extraordinary range of problems and deficiencies at which these techniques are directed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - therapeutic efficacy
KW  - psychotherapeutic techniques
KW  - psychotherapy
KW  - 1984
KW  - Psychotherapeutic Techniques
KW  - Psychotherapy
KW  - Therapeutic Processes
KW  - 1984
U2  - Hariman, Jusuf (Ed). (1983); The Therapeutic Efficacy of the Major Psychotherapeutic Techniques; Springfield, IL: Charles C. Thomas, 1983. 368 pp. $33.50
DO  - 10.1037/023123
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Pearl, David
T1  - Violence and Aggression.
JO  - Society
JF  - Society
Y1  - 1984/09//Sep/Oct84
VL  - 21
IS  - 6
M3  - Article
SP  - 17
EP  - 22
SN  - 01472011
AB  - This article discusses studies on the issue of violence on television in the U.S. The first congressional hearing on television programming took place in 1952 in the U.S. to investigate if television entertainment was excessively violent and sexually provocative. During the period from 1952 to 1967, analyses of programs found a great deal of violence in them. Two governmental commissions investigated the problem of television violence in the late 1960s. Such studies led to an annual content analysis of television programs. They also resulted in a series of unresolved arguments and controversies. The public was not much interested in television violence for reasons not discernible. Citizen groups raised protests against various broadcasting practices. Information on trends in violence depends on the definitions of violence and on the analytic procedures used.
KW  - VIOLENCE on television
KW  - LEGISLATIVE hearings -- United States
KW  - HUMAN sexuality on television
KW  - GOVERNMENTAL investigations
KW  - TELEVISION broadcasting -- United States
KW  - UNITED States
KW  - Experimental Study
KW  - Psychological Factors Affecting Tension
KW  - Tension and its Reduction; Conflict and its Resolutions
N1  - Accession Number: 11392918; Pearl, David 1; Affiliation:  1: Chief, Behavioral Sciences Research Branch, National Institute of Mental Health; Source Info: Sep/Oct84, Vol. 21 Issue 6, p17; Subject Term: VIOLENCE on television; Subject Term: LEGISLATIVE hearings -- United States; Subject Term: HUMAN sexuality on television; Subject Term: GOVERNMENTAL investigations; Subject Term: TELEVISION broadcasting -- United States; Subject Term: UNITED States; Author-Supplied Keyword: Experimental Study; Author-Supplied Keyword: Psychological Factors Affecting Tension; Author-Supplied Keyword: Tension and its Reduction; Conflict and its Resolutions; NAICS/Industry Codes: 515120 Television Broadcasting; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KASID, ATTAN
AU  - STROBL, JEANNINE S.
AU  - HUFF, KAREN
AU  - GREENE, GEOFFREY L.
AU  - LIPPMAN, MARC E.
T1  - A Novel Nuclear Form of Estradiol Receptor in MCF-7 Human Breast Cancer Cells.
JO  - Science
JF  - Science
Y1  - 1984/09/14/
VL  - 225
IS  - 4667
M3  - Article
SP  - 1162
EP  - 1165
SN  - 00368075
AB  - Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to aform that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85680085; KASID, ATTAN 1 STROBL, JEANNINE S. 2 HUFF, KAREN 3 GREENE, GEOFFREY L. 4 LIPPMAN, MARC E. 3; Affiliation:  1: Medicine Branch, National Cancer Institute, Bethesda, Maryland 20205  2: Laboratory of Biochemistry, National Cancer Institute  3: Medicine Branch, National Cancer Institute  4: GEOFFREY L. GREENE Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637; Source Info: 9/14/1984, Vol. 225 Issue 4667, p1162; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - PURO, DONALD G.
AU  - AGARDH, ELISABET
T1  - Insulin-Mediated Regulation of Neuronal Maturation.
JO  - Science
JF  - Science
Y1  - 1984/09/14/
VL  - 225
IS  - 4667
M3  - Article
SP  - 1170
EP  - 1172
SN  - 00368075
AB  - Exposure to insulin increased stimulus-evoked transmission at synapses formed in culture by cholinergic retinal neurons derived from fetal rats. This effect occurred at physiological concentrations and was long lasting. Thefindings support the hypothesis that insulin may serve as a developmental signal to regulate the emergence of effective neurotransmission across nascent synapses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 85680089; PURO, DONALD G. 1 AGARDH, ELISABET 1; Affiliation:  1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 9/14/1984, Vol. 225 Issue 4667, p1170; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MITSUYA, HIROAKI
AU  - POPOVIC, MIKULAS
AU  - YARCHOAN, ROBERT
AU  - MATSUSHITA, SHUZO
AU  - GALLO, ROBERT C.
AU  - BRODER, SAMUEL
T1  - Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-III.
JO  - Science
JF  - Science
Y1  - 1984/10/12/
VL  - 226
IS  - 4671
M3  - Article
SP  - 172
EP  - 174
SN  - 00368075
AB  - A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692099; MITSUYA, HIROAKI 1 POPOVIC, MIKULAS 2 YARCHOAN, ROBERT 3 MATSUSHITA, SHUZO 3 GALLO, ROBERT C. 2 BRODER, SAMUEL 3; Affiliation:  1: Clinical Oncology Program, National Cancer Institute, Bethesda, Maryland 20205  2: Laboratory of Tumor Cell Biology, National Cancer Institute  3: Clinical Oncology Program, National Cancer Institute; Source Info: 10/12/1984, Vol. 226 Issue 4671, p172; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SOMERS, ROBERT L.
AU  - KLEIN, DAVID C.
T1  - Rhodopsin Kinase Activity in the Mammalian Pineal Gland and Other Tissues.
JO  - Science
JF  - Science
Y1  - 1984/10/12/
VL  - 226
IS  - 4671
M3  - Article
SP  - 182
EP  - 184
SN  - 00368075
AB  - Rhodopsin kinase, an enzyrne involved in photochemical transduction in the retina, has been found in the mamtmalian pineal gland in amounts equal to those in the retina; other tissues had 7 percent of this armount, or less. Thisfinding suggests that, ini mammals, rhodopsin kinasefunctions in the pineal gland and other tissues to phosphorylate rhodopsin-like integral membrane receptors and is thereby involved in signal transduction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692103; SOMERS, ROBERT L. 1 KLEIN, DAVID C. 2; Affiliation:  1: Section on Retinal Metabolism, Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205  2: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health; Source Info: 10/12/1984, Vol. 226 Issue 4671, p182; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06406-025
AN  - 2006-06406-025
AU  - Waxler, Carolyn Zahn
T1  - The Social Side of Social Cognition Discovered.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1984/11//
VL  - 29
IS  - 11
SP  - 889
EP  - 890
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06406-025. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Waxler, Carolyn Zahn; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychosocial Development; Social Cognition. Minor Descriptor: Cognitive Science; Social Interaction. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Higgins, E. Tory (Ed); Ruble, Diane N. (Ed); Hartup, Willard W. (Ed). Social Cognition and Social Development: A Sociocultural Perspective=Cambridge, England: Cambridge University Press, 1983. 425 pp. $39.50; 1983. References Available: Y. Page Count: 2. Issue Publication Date: Nov, 1984. 
AB  - Reviews the book, Social Cognition and Social Development: A Sociocultural Perspective edited by E. Tory Higgins, Diane N. Ruble, and Willard W. Hartup (1983). In this advanced and specialized text the editors attempt to integrate concepts and findings of social and cognitive science as they apply to (a) the development of children's social cognitions and (b) the relationships between social cognition and social behavior. The goal of exploring environmental forces that influence children's social cognitions, their social interactions, and the interconnections of their thought and behavior is admirable. The book's contributors represent diverse theoretical perspectives. This book helps to draw us to the edge of a new era in social cognition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - social interactions
KW  - social development
KW  - social behavior
KW  - cognitive science
KW  - social cognition
KW  - 1984
KW  - Psychosocial Development
KW  - Social Cognition
KW  - Cognitive Science
KW  - Social Interaction
KW  - 1984
U2  - Higgins, E. Tory (Ed); Ruble, Diane N. (Ed); Hartup, Willard W. (Ed). (1983); Social Cognition and Social Development: A Sociocultural Perspective; Cambridge, England: Cambridge University Press, 1983. 425 pp. $39.50
DO  - 10.1037/022397
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Kaipainen, Pekka
AU  - Nebert, Daniel W.
AU  - Lang, Matti A.
T1  - Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/11/02/
VL  - 144
IS  - 3
M3  - Article
SP  - 425
EP  - 431
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Phenobarbital-induced coumarin 7-hydroxylase is high in DBA/2J and low in C57BL/6N inbred mice: this genetic difference is encoded by tide Coli locus on chromosome 7. The aim of this study was to develop art antibody specific for this cytochrome P-450 polymorphism. P-450 fractions, highly specific for phenobarbital-inducible coumarin 7-hydroxylase activity, were purified from DBA/2J and C57BL/6N mouse liver microsomes. Both proteins are 49 kDa. as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Soret peaks of the reduced cytochrome · CO complexes are 451 nm. Reconstituted DBA/2J coumarin 7-hydroxylase activity exhibits a V twice as high as, and a Km value 10-fold less than, the reconstituted C57BL/6N activity. Antibodies were raised in rabbit. By Ouchterlony immunodiffusion, both antibodies show 100% cross-reactivity with DBA/2J and C57BL/6N microsomes and purified antigens. Yet, DBA/2J but not C57BL/6N 7-hydroxylase activity is inhibited by the antibody to DBA/2J P-450. Both DBA/2J and C57BL/6N activities are blocked by the antibody to C57BL/6N P-450. Neither antibody has any effect on liver microsomal d-benzphetamine N-demethylase, ethylmorphine N-demethylase, aminopyrine N-demethylase. 7-ethoxycoumarin O-deethylase, acetanilide 4-hydroxylase, or aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity. The DBA/2J protein most specific for phenobarbital-induced coumarin 7-hydroxylation is designated ‘P-450Coh’. Anti-(P-450Coh) precipitates a relatively minor 49-kDa protein from detergent-solubilized microsomes and from in vitro translation of poly(A+)-enriched total RNA of phenobarbital-treated DBA/2J mouse liver, whereas the major phenobarbital-induced P-450 proteins exhibit a molecular mass of about 51 kDa. The immunoprecipitated translation products correspond to a messenger RNA of 2100±100 nucleotides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOCHROME P-450
KW  - CYTOCHROMES
KW  - MONOOXYGENASES
KW  - METALLOENZYMES
KW  - GENETIC polymorphisms
KW  - BIOCHEMISTRY
KW  - CHEMISTRY
N1  - Accession Number: 13833783; Kaipainen, Pekka 1 Nebert, Daniel W. 1 Lang, Matti A. 1; Affiliation:  1: Department of Physiology, University of Kuopio; Laboratory of Developmental Pharmacology National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; and Department of Toxicology, University of Kuopio; Source Info: 11/2/84, Vol. 144 Issue 3, p425; Subject Term: CYTOCHROME P-450; Subject Term: CYTOCHROMES; Subject Term: MONOOXYGENASES; Subject Term: METALLOENZYMES; Subject Term: GENETIC polymorphisms; Subject Term: BIOCHEMISTRY; Subject Term: CHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Farmer, Mary E.
AU  - White, Lon R.
AU  - Brody, Jacob A.
AU  - Bailey, Kent R.
T1  - Race and Sex Difference in Hip Fracture Incidence.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/12//
VL  - 74
IS  - 12
M3  - Article
SP  - 1374
EP  - 1380
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Incidence rates for hip fracture in the United States were estimated using non-federal hospital discharges from the National Hospital Discharge Survey for the years 1974-1979. Age-specific incidence curves for women and for men showed similar patterns of increase in risk with age, with risks approximately doubling every five years after age 50. Age-specific rates by five-year age groups were compared among the four race-sex groups. No significant differences were observed between Black females, Black males, and White males. In contrast, rates for White females were one and one-half to four limes those for Black females after age 40 and were approximately double those for White males alter age 50. Analysis based on an independent data source of non-federal hospital discharges in Washington, DC confirmed these relationships. In the Washington study, White women were at twice the risk for hip fracture (controlled for age) compared with Black women and at 2.7 times the risk for hip fracture (controlled for age) compared to White men. No significant differences were observed between Black women and Black men. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIP joint -- Dislocation
KW  - OSTEOPOROSIS
KW  - BONES -- Diseases
KW  - POISSON distribution
KW  - DISTRIBUTION (Probability theory)
KW  - EPIDEMIOLOGY
KW  - DISEASES -- Causes & theories of causation
KW  - SEX differences (Biology)
KW  - UNITED States
N1  - Accession Number: 4952157; Farmer, Mary E. 1 White, Lon R. 2 Brody, Jacob A. 3 Bailey, Kent R. 1; Affiliation:  1: Senior Staff Fellow, Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, Federal Building, Rm 612, Bethesda, MD 20205.  2: National Institute on Agineg,  3: Mathematica and Pllied Statics Branch, National Health Lung and Blood Institute.; Source Info: Dec1984, Vol. 74 Issue 12, p1374; Subject Term: HIP joint -- Dislocation; Subject Term: OSTEOPOROSIS; Subject Term: BONES -- Diseases; Subject Term: POISSON distribution; Subject Term: DISTRIBUTION (Probability theory); Subject Term: EPIDEMIOLOGY; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: SEX differences (Biology); Subject Term: UNITED States; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brody, Jacob A.
AU  - Farmer, Mary E.
AU  - White, Lon R.
T1  - Absence of Menopausal Effect on Hip Fracture Occurrence in White Females.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1984/12//
VL  - 74
IS  - 12
M3  - Article
SP  - 1397
EP  - 1398
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The rate of hip fracture among White females rises sharply between ages 40 and 44 and then continues at a constant rate of acceleration doubling every five to six years throughout life with no deviation during, or in the years immediately following, menopause. We suggest that the important role of sex hormones and other factors in osteoporosis commences prior to menopause. A premenopause prevention strategy which postpones the onset of the osteoporotic process by live or six years would be expected to reduce the risk of hip fracture by 50 per ¢ throughout the remainder of a woman's life. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIP joint -- Dislocation
KW  - SEX hormones
KW  - MENOPAUSE
KW  - OSTEOPOROSIS
KW  - BONES -- Diseases
KW  - BONE density
KW  - WOMEN patients
KW  - WOMEN -- United States
KW  - UNITED States
N1  - Accession Number: 4952222; Brody, Jacob A. 1 Farmer, Mary E. 1 White, Lon R. 1; Affiliation:  1: Associate Director, Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, Biometry, Program, National Institute on Aging, National Institute of Health, Bethesds, MD 20205.; Source Info: Dec1984, Vol. 74 Issue 12, p1397; Subject Term: HIP joint -- Dislocation; Subject Term: SEX hormones; Subject Term: MENOPAUSE; Subject Term: OSTEOPOROSIS; Subject Term: BONES -- Diseases; Subject Term: BONE density; Subject Term: WOMEN patients; Subject Term: WOMEN -- United States; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Slomczynski, Kazimierz M.
AU  - Krauze, Tadeusz
T1  - SHOULD THE FRAMEWORK OF STRUCTURAL VS. CIRCULATION MOBILITY BE ABANDONED? IF SO, NOT BECAUSE OF FAULTY LOGIC.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1984/12//
VL  - 49
IS  - 6
M3  - Article
SP  - 850
EP  - 852
SN  - 00031224
AB  - In the article, the authors comment on the article "Structural Mobility, Circulation Mobility and Analysis of Occupational Mobility: A Conceptual Mismatch," by Michael E. Sobel, published in the October 1983 issue of the journal "American Sociological Review." According to the authors, Sobel has called for "abandonment of the structure vs. circulation framework" in social mobility studies. He claims that even under the correct interpretation of the intergenerational mobility table--that is, in terms of origin and destination distributions of sons-neither the models of statistical independence nor the traditional indices correctly account for structural and circulation mobility. Commenting on Sobel's conclusion, the authors show that its derivation is based on faulty logic, and therefore is inadmissible. Specifically, two logical fallacies are involved: hasty generalization and a non sequitur. Since Sobel defines circulation mobility residually, his focus is on evaluating solutions to the problem of accounting for structural mobility.
KW  - SOCIAL structure
KW  - OCCUPATIONAL mobility
KW  - SOCIAL mobility
KW  - SOCIOLOGY
KW  - SOCIAL systems
KW  - INTERGENERATIONAL relations
N1  - Accession Number: 14813330; Slomczynski, Kazimierz M. 1; Krauze, Tadeusz 2; Affiliations: 1: National Institute of Mental Health University of Warsaw, Poland; 2: Hofstra University; Issue Info: Dec84, Vol. 49 Issue 6, p850; Thesaurus Term: SOCIAL structure; Thesaurus Term: OCCUPATIONAL mobility; Subject Term: SOCIAL mobility; Subject Term: SOCIOLOGY; Subject Term: SOCIAL systems; Subject Term: INTERGENERATIONAL relations; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Gottesman, Susan
T1  - BACTERIAL REGULATION: GLOBAL REGULATORY NETWORKS.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1984/12//
VL  - 18
M3  - Article
SP  - 415
EP  - 441
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Discusses the role of global regulatory networks in bacterial regulation.  Components of the network which include stimulus and signal, regulatory proteins; Explanation of specific systems for SOS regulation, heat-shock response and SOS systems; Conclusions for the promoter structure and regulators.
KW  - BIOLOGICAL control systems
KW  - BACTERIA
KW  - BACTERIOLOGY
KW  - BIOLOGICAL systems
KW  - BIOLOGY
N1  - Accession Number: 12345431; Gottesman, Susan 1; Affiliation:  1: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland; Source Info: 1984, Vol. 18, p415; Subject Term: BIOLOGICAL control systems; Subject Term: BACTERIA; Subject Term: BACTERIOLOGY; Subject Term: BIOLOGICAL systems; Subject Term: BIOLOGY; Number of Pages: 27p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - CHOMCZYNSKI, PIOTR
AU  - QASBA, PRADMAN
AU  - TOPPER, YALE J.
T1  - Essential Role of Insulin in Transcription of the Rat 25,000 Molecular Weight Casein Gene.
JO  - Science
JF  - Science
Y1  - 1984/12/14/
VL  - 226
IS  - 4680
M3  - Article
SP  - 1326
EP  - 1328
SN  - 00368075
AB  - Insulin is essential for the accumulation of rat casein messenger RNA (mRNA) in the presence of glucocorticoid and prolactin. The accumulation. of certain mRNA's in other tissues has also been linked to insulin action. The present study shows that the accumulation effect on the 25,000 molecular weight rat casein mRNA does not reflect stabilization of the transcript by insulin. Rather, insulin is essential for its synthesis in the presence of glucocorticoid and prolactin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692141; CHOMCZYNSKI, PIOTR 1 QASBA, PRADMAN 2 TOPPER, YALE J. 3; Affiliation:  1: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 2020S  2: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205  3: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases; Source Info: 12/14/1984, Vol. 226 Issue 4680, p1326; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KENNEY, SHANNON
AU  - NATARAJAN, VENKATACHALA
AU  - STRIKE, DAVID
AU  - KHOURY, GEORGE
AU  - SALZMAN, NORMAN P.
T1  - JC Virus Enhancer-Promoter Active in Human Brain Cells.
JO  - Science
JF  - Science
Y1  - 1984/12/14/
VL  - 226
IS  - 4680
M3  - Article
SP  - 1337
EP  - 1339
SN  - 00368075
AB  - A human papovavirus, JCV, is the etiologic agent of the fatal demyelinating disease, progressive multifocal leukoencephalopathy. The JCV 98-base-pair tandem repeats, located to the late side of the viral replication origin, were shown to be a transcriptional regulatory element with enhancer-like activity in human fetal glial cells, These tandem repeats share significant homology with the 82-nucleotide rat brain-specific identifier RNA sequence. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692146; KENNEY, SHANNON 1 NATARAJAN, VENKATACHALA 1 STRIKE, DAVID 1 KHOURY, GEORGE 1 SALZMAN, NORMAN P. 1; Affiliation:  1: Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 12/14/1984, Vol. 226 Issue 4680, p1337; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wiebel, Friedrich J.
AU  - Sang Shin Park
AU  - Kiefer, Franz
AU  - Gelboin, Harry V.
T1  - Expression of cytochromes P-450 in rat hepatoma cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1984/12/17/
VL  - 145
IS  - 3
M3  - Article
SP  - 455
EP  - 462
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have studied the expression of aldrin epoxidase (AE), 7-ethoxycoumarin-O-deethylase (ECDE), and aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH) in nine differentiated or dedifferentiated cell lines derived from H4IIEC3 rat hepatoma cells. The nature of the cytochromes P-450 mediating AE, ECDE and AHH activities was analysed using monoclonal antibodies (MAb) made to the major 3-methylcholanthrene-induced cytochrome P-450 (MAb-MC) or phenobarbital-induced cytochrome P-450 (MAb-PB) from rat liver. The cells were treated with 5 μM dexamethasone for 30 h to increase the levels of the monooxygenase activities. (a) The six differentiated cell lines examined (Faza967, Fao, HF1–4, 2sFou, C2Rev7, and H4IIEC3/G-) contained MAb-PB-sensitive AE comprising 30–75% of the total AE activity. In most of these cell lines MAb-PB also markedly inhibited ECDE; however, the antibody had a considerably weaker effect on AHH. (b) MAb-PB-sensitive AHH, ECDE and AE activities were also observed in untreated and phenobarbital-treated ceils. (c) MAb-MC inhibited AHH and ECDE in the two dedifferentiated lines HF1 and H5 by 50–80%. The antibody also inhibited AHH activities in the poorly differentiated line H41IEC3/T and in the majority of the differentiated lines by 40–65%. MAb-MC-sensitive AHH was found in Fao cells after treatment with benz[a]anthracene but not with dexamethasone. C2Rev7 cells did not contain detectable MAb-MC-sensitive AHH. (d) Benz[a]anthracene induced AHH in H4IIEC3/T, H4IIEC3/G-, and 2sFou cells 20–30-fold and in Faza967 and Fao cells 3–5-fold. Benz[a]anthracene remained without effect on AHH activity in C2Rev7 cells. various degrees phenobarbital-inducible The results show that the hepatoma cells examined express to cytochrome P-450 and/or 3-methylcholanthrene-inducible cytochrome P-450. These cell lines are versatile tools for studying the regulation of monooxygenase activities and analysing their role in the activation and inactivation of xenobiotics such as carcinogens, drugs and pesticides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOCHROME P-450
KW  - MONOOXYGENASES
KW  - ALDRIN
KW  - HYDROCARBONS
KW  - HEPATOMA
KW  - CANCER cells
KW  - MONOCLONAL antibodies
N1  - Accession Number: 13831977; Wiebel, Friedrich J. 1 Sang Shin Park 1 Kiefer, Franz 1 Gelboin, Harry V. 1; Affiliation:  1: Institut für Toxikologie und Biochemie, Abteilung für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg; and Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 12/17/84, Vol. 145 Issue 3, p455; Subject Term: CYTOCHROME P-450; Subject Term: MONOOXYGENASES; Subject Term: ALDRIN; Subject Term: HYDROCARBONS; Subject Term: HEPATOMA; Subject Term: CANCER cells; Subject Term: MONOCLONAL antibodies; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - Gen
ID  - 9999-07723-000
AN  - 9999-07723-000
AU  - Hunter, Fumiyo Tao
T1  - Adolescent Conversation Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1985///
AD  - Hunter, Fumiyo Tao, National Institute of Child Health and Human Development, Child and Family Research Section, Building 31, Room B2B15, Bethesda, Maryland, United States, 20205
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: Unknown. Test Items: Yes
N1  - Accession Number: 9999-07723-000. Partial author list: First Author & Affiliation: Hunter, Fumiyo Tao; National Institute of Child Health and Human Development, Child and Family Research Section, Bethesda, Maryland, United States. Release Date: 20111212. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: The rating categories were: We don't discuss this topic (1), not often (2), sometimes (3), and often (4).. Language: English. Constructs: Communication Patterns; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Adolescent Conversation Questionnaire is to assess patterns of communication between adolescents and their parents and friends.
AB  - Description: The Adolescent Conversation Questionnaire (Hunter, 1984) was developed within the context of a study that examined adolescents' perceptions of discussions with parents and friends with reference to the academic/vocational, social/ethical, family, and peer domains. A total of 180 subjects completed a paper-and-pencil questionnaire: 30 males and 30 females represented each of three age groups: 12-13-, 14-15-, and 18-20- year-olds. The questionnaire contained three identical sections, each referring to father, mother, or a friend. Each section began with a question referring to the seven topics of conversation that followed. For each of the seven items, subjects rated (a) how often their fathers (mothers, friends) explain reasons for their ideas and (b) how often their fathers (mothers, friends) try to understand their ideas. The following four scales were computed: academic/vocational issues (Items 1 and 3), social/ethical issues (Items 6 and 7), family relationships (Item 5), and peer relationships (Items 2 and 4). computed for the explanation and understanding scores for three scales and three relationships. They ranged from .24 to .65, with 11 of 18 being above .40. Three scales— explanation by mothers about academic/vocational topics, explanation by friends about friendship topics, and explanation by mothers about social/ethical topics—had reliabilities of .35 or below. Discussion levels for parents remained substantial across ages in the academic/vocational, social/ethical, and family domains. Discussions with friends about these domains increased with age, and peer relationship issues were discussed more with friends than with parents in all age groups. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Adolescent Conversation Questionnaire
KW  - Social Attitudes
KW  - Test Development
U5  - Adolescent Conversation Questionnaire [Test Development]Adolescents' perception of discussions with parents and friends. (AN: 1985-25202-001 from PsycINFO) Hunter, Fumiyo T.; May, 1985. Source: Developmental Psychology. 21(3), American Psychological Association, US; May, 1985; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Adolescents (Ages 12-20); Location: United States Keywords: Adolescent Conversation Questionnaire; Social Attitudes; Test Development; Subjects: Adolescent Attitudes; Adolescent Development; Conversation; Parent Child Communication; Peer Relations; Psychosocial Development; Questionnaires; Test Construction;
DO  - 10.1037/t07723-000
L3  - Full; Full text; 999907723_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-12108-000
AN  - 9999-12108-000
AU  - McCrae, Robert R.
AU  - Costa, Paul T. Jr.
T1  - Bipolar Adjective Rating Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1985///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-12108-000. Partial author list: First Author & Affiliation: McCrae, Robert R.; National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland, United States. Release Date: 20120611. Correction Date: 20160808. Instrument Type: Rating Scale. Test Format: Eighty adjective pairs are rated on a 9-point scale.. Language: English. Constructs: Personality; Classification: Personality (7200). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the scale is to assess personality traits based on the Norman's (1963) five-factor model as well as the Neuroticism, Extraversion, Openness (NEO) model.
AB  - Description: The Bipolar Adjective Rating Scale (McCrae & Costa, 1985) assesses personality traits based on the Norman's (1963) five-factor model as well as the Neuroticism, Extraversion, Openness (NEO) model. It consists of 80 adjective pairs, with 8 pairs each measuring the five factors of Extraversion or Surgency; Agreeableness; Emotional Stability vs. Neuroticism; Culture; and Conscientiousness (from the Five-Factor Model), 8 pairs each measuring Neuroticism, Extraversion, and Openness (from the NEO Model), and additional items for agreeableness and conscientiousness, suggested by an analysis of longer lists of adjectives reported by Goldberg (1980). Adjective pairs are rated on a 9-point scale. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Bipolar Adjective Rating Scale
KW  - Test Development
KW  - Five-Factor Model
KW  - Personality Traits
U5  - Bipolar Adjective Rating Scale [Test Development]Updating Norman's "adequacy taxonomy": Intelligence and personality dimensions in natural language and in questionnaires. (AN: 1986-03750-001 from PsycINFO) McCrae, Robert R.; Costa, Paul T.; Sep, 1985. Source: Journal of Personality and Social Psychology. 49(3), American Psychological Association, US; Sep, 1985; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Sample: Community-Dwelling Volunteers (Ages 24-89); Location: United States Keywords: Bipolar Adjective Rating Scale; Test Development; Five-Factor Model; Personality Traits; Subjects: Adjectives; Five Factor Personality Model; Personality Traits; Rating Scales; Test Construction;
DO  - 10.1037/t12108-000
L3  - Full; Full text; 999912108_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-19441-000
AN  - 9999-19441-000
AU  - Hunter, Fumiyo Tao
T1  - Unilateral and Mutual Interactions with Parents and Peers Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1985///
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No
N1  - Accession Number: 9999-19441-000. Partial author list: First Author & Affiliation: Hunter, Fumiyo Tao; National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland, United States. Release Date: 20130311. Test Format: Each question is followed by 4 unilateral and 4 mutual response statements. The 32 response items are repeated in father, mother, and friend sections. Subjects rate, on a scale of 1 (Hardly Ever) to 4 (Very Often), how often the interactions described under Questions 1 and 3 occur in their interactions with parents and friends. The items under Questions 2 and 4 are rated as 1 (Not the Reason at All) to 4 (My Main Reason).. Language: English. Constructs: Adolescent Interactions; Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). 
AB  - Purpose: The purpose of this scale is to examine how adolescents experience the interplay of interactions with mothers, fathers, and friends.
AB  - Description: A Unilateral and Mutual Interactions with Parents and Peers Questionnaire was developed by Hunter in 1985. It was constructed in a study examining how individual adolescents experience the interplay of interactions with mothers, fathers, and friends. Participants were adolescents in the 12-13, 14-15, and 18- 20 year range. The questionnaire consisted of 4 questions, each followed by 4 unilateral and 4 mutual response statements. The unilateral items described the other person (a parent or a friend) as expecting compliance or giving advice based on greater expertise and didactic concerns. The mutual items represented the other person negotiating or sharing problem solving based on common interests, problems, and uncertainties. The 32 response items were repeated in father, mother, and friend sections, with the appropriate changes of wording and personal pronouns. Unilateral and mutual scale scores were computed as unweighted averages of 16 items each; 3 sets of unilateral and mutual scores were calculated for father, mother, and friend data. The Cronbach's alphas for the unilateral items were .80, .77, and .72 for the father, mother, and friend scales, respectively. The corresponding alphas for the mutual items were .82, .77, and .80.
KW  - Internal Consistency
KW  - Test Development
KW  - Unilateral and Mutual Interactions with Parents and Peers Questionnaire
U5  - Unilateral and Mutual Interactions with Parents and Peers Questionnaire [Test Development]Individual adolescents' perceptions of interactions with friends and parents. (AN: 1986-29706-001 from PsycINFO) Hunter, Fumiyo T.; Fal, 1985. Source: The Journal of Early Adolescence. 5(3), Sage Publications, US; Fal, 1985; Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Location: United States; Sample: Adolescents Keywords: Internal Consistency; Test Development; Unilateral and Mutual Interactions with Parents and Peers Questionnaire; Subjects: Aptitude Measures; Friendship; Interpersonal Interaction; Parent Child Relations; Test Reliability;
DO  - 10.1037/t19441-000
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-26705-000
AN  - 9999-26705-000
AU  - Secunda, Steven K.
AU  - Katz, Martin M.
AU  - Swann, Alan
AU  - Koslow, Stephen H.
AU  - Maas, James W.
AU  - Chuang, Sidney
AU  - Croughan, Jack
T1  - Manic Diagnostic and Severity Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1985///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-26705-000. Other Names: Mania Diagnostic and Severity Scale. Acronyms: MADS. Partial author list: First Author & Affiliation: Secunda, Steven K.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20140210. Correction Date: 20151109. Instrument Type: Rating Scale. Test Location: Appendix 2, Page 120; Appendix 1, Page 120. Test Format: Physicians/nurses provide ratings for each of the 23 descriptors.. Language: English. Constructs: Mania; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). 
AB  - Purpose: The purpose of the Manic Diagnostic and Severity Scale is to provide a composite measure of manic symptoms. It represents a combining of previously validated tests in order to obtain greater breadth and sensitivity in diagnosis and in the assessment of severity and change.
AB  - Description: The Manic Diagnostic and Severity Scale (MADS; Secunda et al., 1985) assesses mania by integrating subscales from three established measures: 1. Schedule of Affective Disorders and Schizophrenia (SADS; Spitzer & Endicott, 1978), 2. Video Interview Behavior Evaluation Scale (VIBES; Katz & Itil, 1974), and 3. Affective Disorder Rating Scale (ADRS; Murphy, Pickar, & Alterman, 1980). To measure the symptoms characteristic of mania as judged by the clinician, the 5-item SADS-C-17 scale is used. It provides a profile of the major manic features and would appear to represent a core syndrome for mania. It contains elements which correspond more to the elation-grandiose (E-G) index proposed by Beigel and Murphy (1971). The 6-item, physician-rated VIBES Factor B-2 Scale is used to emphasize the angry and negative side of the syndrome, and corresponds with Beigel and Murphy's (1971) paranoid-destructive (P-D) characterization. Two factors are derived from the nurse-rated ADRS: 1. Factor 1 (9 items), which describes a manic syndrome weighted with P-D elements and 2. Factor 2 (3 items), which describes an E-G subtype. These four factors are 'summed' to create a severity score for the MADS. Using a sample of manic patients, interrater reliability was found to be high. The MADS also demonstrated evidence of discriminant validity and sensitivity to change. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Affective Disorder Rating Scale
KW  - Discriminant Validity
KW  - Inter-Rater Reliability
KW  - Manic Diagnostic and Severity Scale
KW  - Schedule of Affective Disorders and Schizophrenia
KW  - Video Interview Behavior Evaluation Scale
KW  - Test Development
KW  - Rating Scales
U5  - Manic Diagnostic and Severity Scale (MADS) [Test Development]Mania: Diagnosis, state measurement and prediction of treatment response. (AN: 1986-06597-001 from PsycINFO) Secunda, Steven K.; Katz, Martin M.; Swann, Alan; Koslow, Stephen H.; Maas, James W.; Chuang, Sidney; Croughan, Jack; Mar-Apr, 1985. Source: Journal of Affective Disorders. 8(2), Elsevier Science, Netherlands; Mar-Apr, 1985; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Age Range: 23-74 Years; Sample: Manic Patients Keywords: Affective Disorder Rating Scale; Discriminant Validity; Inter-Rater Reliability; Manic Diagnostic and Severity Scale; Schedule of Affective Disorders and Schizophrenia; Video Interview Behavior Evaluation Scale; Test Development; Subjects: Bipolar Disorder; Mania; Medical Diagnosis; Severity (Disorders); Test Construction; Test Reliability; Test Validity;
U5  - Manic Diagnostic and Severity Scale (MADS) [Test Use]Specificity of mixed affective states: Clinical comparison of dysphoric mania and agitated depression. (AN: 1993-45473-001 from PsycINFO) Swann, Alan C.; Secunda, Steven K.; Katz, Martin M.; Croughan, Jack; Bowden, Charles L.; Koslow, Stephen H.; Berman, Nancy; Stokes, Peter E.; Jun, 1993. Source: Journal of Affective Disorders. 28(2), Elsevier Science, Netherlands; Jun, 1993; Population: Human; Inpatient; Sample: Mixed (Dysphoric) Manics; Agitated Depressed Patients Keywords: Affective Disorder Rating Scale; Discriminant Validity; Inter-Rater Reliability; Manic Diagnostic and Severity Scale; Schedule of Affective Disorders and Schizophrenia; Video Interview Behavior Evaluation Scale; Rating Scales; Subjects: Bipolar Disorder; Mania; Medical Diagnosis; Rating Scales; Severity (Disorders); Test Reliability; Test Validity;
DO  - 10.1037/t26705-000
L3  - Full; Full text; 999926705_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Naoi, Atsushi
AU  - Schooler, Carmi
T1  - Occupational Conditions and Psychological Functioning in Japan.
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1985/01//
VL  - 90
IS  - 4
M3  - Article
SP  - 729
EP  - 752
SN  - 00029602
AB  - Compares working conditions in Japan and the United States and tests whether the reciprocal effects of occupational conditions and psychological functioning in Japan are similar to those found in the United States.
KW  - OCCUPATIONAL prestige
KW  - AUTONOMY (Psychology)
KW  - EMPLOYEES
KW  - WORK environment
KW  - SOCIAL psychology
KW  - JAPAN
KW  - UNITED States
N1  - Accession Number: 15648833; Naoi, Atsushi 1,2; Schooler, Carmi 2; Affiliations: 1 : University of Osaka, University of Tokyo; 2 : U.S. National Institute of Mental Health;  Source Info: Jan85, Vol. 90 Issue 4, p729; Historical Period: 1974 to 1980; Subject Term: OCCUPATIONAL prestige; Subject Term: AUTONOMY (Psychology); Subject Term: EMPLOYEES; Subject Term: WORK environment; Subject Term: SOCIAL psychology; Subject: JAPAN; Subject: UNITED States; Number of Pages: 24p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Eil, Charles
AU  - Cutler, Jr., Gordon B.
AU  - Loriaux, D. Lynn
T1  - Androgen Receptor Characteristics in Skin Fibroblasts from Hirsute Women.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/01//
VL  - 84
IS  - 1
M3  - Article
SP  - 62
EP  - 65
SN  - 0022202X
AB  - Hormonal measurements in some women with hirsutism often reveal little or no elevation in androgen levels to explain the disorder. Thus, it has been postulated that increased sensitivity of the hair follicle to androgen may contribute to the development of hirsutism in such patients. We, therefore, sought androgen receptor abnormalities in skin fibroblasts cultured from 10 hirsute women (ages 17-43) and normal or mildly elevated plasma testosterone levels (28-82 ng/dl). Androgen receptor content (Ro) and binding affinity (Kd) in cultured pubic skin fibroblasts were measured using a dispersed, whole cell assay. Ten such cell lines from these women were compared with 19 pubic skin cell lines from 9 normal volunteers (6 males and 3 females) and from 10 other subjects (males with gynecomastia or hypospadias). There was no statistically significant difference in the mean androgen receptor content (11,600 ± 2700 (SE) sites/cell fibroblasts vs 7900 ± 700 sites/cell or binding affinity (2.0 ± 0.3 (SE) × 10[sup-9] M vs 1.5 ± 0.2 × 10-9 M, respectively) between the patients' fibroblasts and those of the controls. We conclude that hirsutism cannot be explained by abnormalities in fibroblast androgen receptor number or affinity. These observations do not exclude the possibility that other mechanisms might lead to increased peripheral androgen sensitivity in such patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANDROGENS
KW  - HYPERTRICHOSIS
KW  - WOMEN
KW  - SKIN
KW  - FIBROBLASTS
KW  - HAIR follicles
KW  - PATIENTS
N1  - Accession Number: 12274829; Eil, Charles 1 Cutler, Jr., Gordon B. Loriaux, D. Lynn 1; Affiliation:  1: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1985, Vol. 84 Issue 1, p62; Subject Term: ANDROGENS; Subject Term: HYPERTRICHOSIS; Subject Term: WOMEN; Subject Term: SKIN; Subject Term: FIBROBLASTS; Subject Term: HAIR follicles; Subject Term: PATIENTS; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12274829
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morgan, B.L.G.
AU  - Kuyatt, B.L.
AU  - Fink, J.
T1  - Effects of hypothyroidism on the DNA, carbohydrate, soluble protein and sialic acid contents of rat submandibular glands.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1985/01//
VL  - 14
IS  - 1
M3  - Article
SP  - 37
EP  - 41
SN  - 03009777
AB  - Submandibular glands are a target organ of thyroid hormones. This study examine the effects of hypothyroidism on the biochemical characteristics of these glands in the rat. There were no effects on the neutral sugar and DNA contents. However, soluble protein concentrations (µg/mg wet weight) were significantly decreased and sialic acid concentrations µ/mg soluble protein) were significantly elevated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYPOTHYROIDISM
KW  - DNA
KW  - SUBMANDIBULAR gland
KW  - SIALIC acids
KW  - PROTEINS
KW  - CARBOHYDRATES
KW  - RATS
N1  - Accession Number: 11478906; Morgan, B.L.G. 1 Kuyatt, B.L. 1 Fink, J. 1; Affiliation:  1: Division of Preventive Dentistry, Columbia University and Laboratory of Molecular Aging, National Institutes of Health, USA; Source Info: Jan85, Vol. 14 Issue 1, p37; Subject Term: HYPOTHYROIDISM; Subject Term: DNA; Subject Term: SUBMANDIBULAR gland; Subject Term: SIALIC acids; Subject Term: PROTEINS; Subject Term: CARBOHYDRATES; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1600-0714.ep11478906
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2009-05165-001
AN  - 2009-05165-001
AU  - Mirsky, Allan F.
T1  - Addendum: Bringing the Israeli high-risk study to completion.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1985///
VL  - 11
IS  - 1
SP  - 30
EP  - 30
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-05165-001. Partial author list: First Author & Affiliation: Mirsky, Allan F.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Nature Nurture; Schizophrenia. Minor Descriptor: Evolutionary Psychology; Scientific Communication. Classification: Schizophrenia & Psychotic States (3213). Page Count: 1. Issue Publication Date: 1985. 
AB  - The project discussed in the preceding introduction and as detailed by various authors in the subsequent articles was a natural evolution of David Rosenthal's scientific study of the nature-nurture issue in the development of schizophrenia. Rosenthal's genius in developing fruitful research designs in the study of schizophrenia is evident throughout this issue of the Schizophrenia Bulletin. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - natural evolution
KW  - nature-nurture
KW  - David Rosenthal
KW  - schizophrenia development
KW  - scientific communication
KW  - 1985
KW  - Nature Nurture
KW  - Schizophrenia
KW  - Evolutionary Psychology
KW  - Scientific Communication
KW  - 1985
DO  - 10.1093/schbul/11.1.30
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-05168-001
AN  - 2009-05168-001
AU  - Silberman, Edward K.
AU  - Mirsky, Allan F.
T1  - The NIMH-Israeli Schizophrenia Project: The history of a high-risk study.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1985///
VL  - 11
IS  - 1
SP  - 146
EP  - 149
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Mirsky, Allan F., Laboratory of Psychology and Psychopathology, NIMH, Bldg. 10, Rm. 4C-110, Bethesda, MD, US, 20205
N1  - Accession Number: 2009-05168-001. PMID: 3983574 Partial author list: First Author & Affiliation: Silberman, Edward K.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Experimentation; Longitudinal Studies; Methodology; Schizophrenia. Classification: Research Methods & Experimental Design (2260); Schizophrenia & Psychotic States (3213). Population: Human (10). Location: Israel. Page Count: 4. Issue Publication Date: 1985. 
AB  - We have reviewed some of the difficulties encountered in bringing this study to completion. Among our special problems were the necessity of collecting large numbers of measures on a relatively small study population, the need to recruit and maintain a staff over long periods of time, the wide geographical separation between staff members responsible for design and those responsible for execution of the study, and the difficulties of conducting longitudinal research in a politically unstable part of the world. Centralization of data and data analysis proved a crucial step in bringing the study to its present level of completion. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - NIMH-Israeli Schizophrenia Project
KW  - high risk populations
KW  - longitudinal studies
KW  - research methods
KW  - study limitations
KW  - 1985
KW  - At Risk Populations
KW  - Experimentation
KW  - Longitudinal Studies
KW  - Methodology
KW  - Schizophrenia
KW  - 1985
DO  - 10.1093/schbul/11.1.146
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09756-007
AN  - 2005-09756-007
AU  - Breznitz, Shlomo
T1  - Chores as a Buffer Against Risky Interaction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1985///
VL  - 11
IS  - 3
SP  - 357
EP  - 360
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Breznitz, Shlomo, NIMH, Parklawn Bldg., Rm. 14C-02, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09756-007. Partial author list: First Author & Affiliation: Breznitz, Shlomo; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20060123. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Child Care; Kibbutz; Mental Disorders; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: 1985. 
AB  - Comments on the National Institute of Mental Health-Israeli high-risk study on children of schizophrenics (SZs), examining the unexpected finding that kibbutz (KB)-reared index Ss showed a higher incidence of psychiatric disorders than their family-reared counterparts. This finding suggests that there is an interaction between the developmental sequence from premorbid to morbid states and some environmental factors associated with the KB environment. It is hypothesized that as long as the SZ parent is able to carry out his/her instrumental role vis-a-vis the child, the relatively simple repetitious chores shield the interaction from drifting into possibly more disturbing patterns. Instead of trying to touch briefly on the many facets of this research, I chose to concentrate on a single, but most intriguing aspect of the results. Specifically, I wish to consider the unexpected finding that at the time of the last followup, kibbutz-reared index subjects (born to a schizophrenic parent) showed a higher incidence of psychiatric disorders than their cityreared counterparts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - kibbutz
KW  - schizophrenia
KW  - schizophrenic parents
KW  - psychiatric disorders
KW  - child care
KW  - 1985
KW  - Child Care
KW  - Kibbutz
KW  - Mental Disorders
KW  - Schizophrenia
KW  - 1985
DO  - 10.1093/schbul/11.3.357
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09756-011
AN  - 2005-09756-011
AU  - Gibbons, Robert D.
AU  - Lewine, Richard R. J.
AU  - Davis, John M.
AU  - Schooler, Nina R.
AU  - Cole, Jonathan O.
T1  - An Empirical Test of a Kraepelinian vs. a Bleulerian View of Negative Symptoms.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1985///
VL  - 11
IS  - 3
SP  - 390
EP  - 396
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Gibbons, Robert D., Illinois State Psychiatric Institute, 1601 West Taylor St., Rm. 529 West, Chicago, IL, US, 60612
N1  - Accession Number: 2005-09756-011. PMID: 4035302 Partial author list: First Author & Affiliation: Gibbons, Robert D.; Department of Biostatistics, University of Illinois, Chicago, IL, US. Other Publishers: Oxford University Press. Release Date: 20060123. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Positive and Negative Symptoms; Psychiatric Symptoms. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Inpatient Multidimensional Psychiatric Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: 1985. 
AB  - Confirmatory factor analysis was used to test a Kraepelinian vs. a Bleulerian interpretation of negative symptoms. The former focuses on absolute loss of functioning, while the latter emphasizes the qualitative loss of organization. Contrary to expectation, neither theory was confirmed, but rather three independent factors emerged: apathy, psychomotor retardation, and loss of goal. The implications of these findings for subtyping schemes and the conceptualization of negative symptoms are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - negative symptoms
KW  - Kraepelinian interpretation
KW  - Bleulerian interpretation
KW  - 1985
KW  - Positive and Negative Symptoms
KW  - Psychiatric Symptoms
KW  - 1985
DO  - 10.1093/schbul/11.3.390
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Witschi, H. P.
AU  - Tryka, A. F.
AU  - Mauderly, J. L.
AU  - Haschek, W. M.
AU  - Satterfield, L. C.
AU  - Bowles, N. D.
AU  - Boyd, M. R.
T1  - Long‐term effects of repeated exposure to 3‐methylfuran in hamsters and mice.
JO  - Journal of Toxicology & Environmental Health
JF  - Journal of Toxicology & Environmental Health
Y1  - 1985/01/02/
VL  - 16
IS  - 3/4
M3  - Article
SP  - 581
EP  - 592
SN  - 00984108
AB  - Male and female Syrian golden hamsters were exposed for 2 h once a week for 10 consecutive weeks to 344 μmol/l of 3‐methylfuran (3MF), an agent known to produce acute Clara‐cell necrosis. Ten months later their respiratory function was evaluated. No functional differences were found between control and treated animals, and his‐topathologic evaluation of the lungs did not reveal any major treatment‐related alterations. Male and female BALB/c mice were exposed for 1 h to 26.8 μmol/l of 3MF once weekly for 10 wk. After 2 yr the tumor incidence in exposed animals was not increased when compared to controls. It is concluded that the acute Clara‐cell necrosis produced by 3MF at the doses used is of little long‐term consequence. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75457213; Witschi, H. P. 1 Tryka, A. F. 2,3 Mauderly, J. L. 4 Haschek, W. M. 5,6 Satterfield, L. C. 5 Bowles, N. D. 5 Boyd, M. R. 7; Affiliation:  1: Biology Division, Oak Ridge National Laboratory, P. O. Box Y, Oak Ridge, Tennessee, 37831  2: Department of Pathology, Memorial Research Center, University of Tennessee, Knoxville, Tennessee  3: University of Arkansas for the Medical Sciences, Little Rock, Arkansas, 72203  4: Inhalation Toxicology Research Institute, Albuquerque, New Mexico  5: Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee  6: College of Veterinary Medicine, University of Illinois, Urbana, Illinois, 61801  7: Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland; Source Info: Jan1985, Vol. 16 Issue 3/4, p581; Number of Pages: 12p; Document Type: Article
L3  - 10.1080/15287398509530765
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DERSE, DAVID
AU  - CARADONNA, SALVATORE J.
AU  - CASEY, JAMES W.
T1  - Bovine Leukemia Virus Long Terminal Repeat: A Cell Type-Specific Promoter.
JO  - Science
JF  - Science
Y1  - 1985/01/18/
VL  - 227
IS  - 4684
M3  - Article
SP  - 317
EP  - 320
SN  - 00368075
AB  - The functional activity of the promoter unit contained within the long terminal repeat (LTR) of bovine leukemia virus (BLV) was examined by monitoring transient expression of a heterologous gene placed under its control. Various cell lines were transfected with recombinant plasmids carrying the bacterial chloramphenicol acetyltransferase (CAT) gene coupled to the BLV LTR (pBL-cat). Transient expression of CAT activity directed by the BLV LTR was observed only in the established BLV-producer cell lines derived from fetal lamb kidney (FLK) cells and bat lung cells. The amount of CAT activity transiently expressed in FLK-BLV cells was decreased approximately tenfold by deletion of LTR sequences located within a region 100 to 170 nucleotides upstream of the RNA start site. Surprisingly, removal of the region 50 base pairs downstream of the RNA initiation site to the 3'- end of the LTR reduced the expression of CAT activity by 87 percent. The BLV LTR thus appears to be an unusual promoter unit, functioning in a cell type-specific manner and possessing sequences on both the 5' and 3' sides of the RNA start site that influence gene expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461107; DERSE, DAVID 1 CARADONNA, SALVATORE J. 2 CASEY, JAMES W. 3; Affiliation:  1: Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701  2: Department of Pharmacology, Louisiana State University Medical Center, New Orleans 70112  3: Section of Genetics, Laboratory of Viral Carcinogenesis; Source Info: 1/18/1985, Vol. 227 Issue 4684, p317; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hintner, Helmut
AU  - Neises, Gabrielle R.
AU  - Lawley, Thomas J.
T1  - Immunologic Properties of Enzymatically Degraded Human Keratin Intermediate Filaments.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/02//
VL  - 84
IS  - 2
M3  - Article
SP  - 108
EP  - 113
SN  - 0022202X
AB  - In order to gain insight into the metabolism of keratin intermediate filaments (KIF) as well as the ability of KIF degradation products to interact with the immune system, we performed enzymatic degradation of purified KIF and examined their interaction with anti-KIF autoantibodies and their ability to act as immunogens. Aliquots of KIF aggregates were exposed to 3 different enzymes, that is, α-chymotrypsin, plasmin, and trypsin, in dose- and time-dependent experiments. The effect of the digestion was monitored sequentially by polyacrylamide gel electrophoresis and simultaneously by transmission electron microscopy. Furthermore the KIF degradation proteins were then examined for their ability to bind anti-KIF autoantibodies by immunoblot and for their immunogenicity. In addition, preincubation of KIF with anti-KIF autoantibodies prior to the digestion procedure was performed to investigate a possible protective effect of this treatment against proteolytic degradation. The experiments demonstrated that: (1) KIF are degraded by serine proteinases, (2) with prolonged incubation time intact KIF are progressively replaced by more granular-amorphous material in transmission electron microscopy, (3) anti-KIF autoantibodies bind to KIF degradation proteins, (4) preincubation of KIF with anti-KIF autoantibodies does not exert any major protective effect for KIF against proteolytic degradation, and (5) the enzymatic degradation products of KIF can function as effective immunogens causing the formation of high-titer anti-KIF antibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATIN
KW  - CYTOPLASMIC filaments
KW  - IMMUNE system
KW  - CHYMOTRYPSIN
KW  - PLASMIN
KW  - IMMUNOLOGY
N1  - Accession Number: 12275037; Hintner, Helmut 1 Neises, Gabrielle R. 1 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb85, Vol. 84 Issue 2, p108; Subject Term: KERATIN; Subject Term: CYTOPLASMIC filaments; Subject Term: IMMUNE system; Subject Term: CHYMOTRYPSIN; Subject Term: PLASMIN; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12275037
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hofferth, Sandra L.
T1  - Updating Children's Life Course.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1985/02//
VL  - 47
IS  - 1
M3  - Article
SP  - 93
SN  - 00222445
AB  - Dramatic changes have occurred in children's family experiences, and these changes are even more dramatic when actual living arrangements, not just parental marital statuses, are considered. According to data from the Panel Study of Income Dynamics, by age 17, 19% of white children born in 1950-1954 had lived with only one parent. By age 17, 70% of white children born in 1980 are projected to have spent at least some time with only one parent before they reach age 18. The proportion was 48% for black children born in 1950-1954 and is projected to be 94% for black children born in 1980. Of course, these figures do not indicate the actual proportion of their lives children spend in various family types. White children born in 1950-1954 could expect to spend 8% of their childhood with only one parent, black children 22%. Of those children born in 1980, white children can be expected to spend 31 % of their childhood years with one parent, black children 59%. Children's experience depends on family type at birth. Sixty-four percent of white children born in 1980 into a first-marriage family could expect to live at some point in a one-parent family by age 17; they could expect to spend 25% of their childhood in such a family. The comparable figures are 89% and 44% for black children born in the same year. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD rearing
KW  - FAMILIES
KW  - INCOME
KW  - DOMESTIC relations
KW  - MARITAL status
N1  - Accession Number: 5274667; Hofferth, Sandra L. 1; Affiliation:  1: National Institute of Child Health and Human Development.; Source Info: Feb85, Vol. 47 Issue 1, p93; Subject Term: CHILD rearing; Subject Term: FAMILIES; Subject Term: INCOME; Subject Term: DOMESTIC relations; Subject Term: MARITAL status; Number of Pages: 23p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Charon, J. A.
AU  - Mergenhagen, S. E.
AU  - Gallin, J. I.
T1  - Gingivitis and oral ulceration in patients with neutrophil dysfunction.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1985/02//
VL  - 14
IS  - 2
M3  - Article
SP  - 150
EP  - 155
SN  - 03009777
AB  - In this study, the gingival condition of patients with neutrophil dysfunction has been evaluated. The data demonstrate increased gingival disease as well as oral ulcerations in patients with neutrophil dysfunction syndromes and are consistent with a critical role of neutrophils in oral health. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GINGIVITIS
KW  - NEUTROPHILS
KW  - MOUTH -- Ulcers
KW  - SYNDROMES
KW  - ORAL diseases
N1  - Accession Number: 11541125; Charon, J. A. 1 Mergenhagen, S. E. 1 Gallin, J. I. 1; Affiliation:  1: Cellular Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research and the Bacterial Diseases Section, Laboratory of Clinical  Investigation, National  Institute of Allergy and Infectious Diseases,  Bethesda, USA; Source Info: Feb85, Vol. 14 Issue 2, p150; Subject Term: GINGIVITIS; Subject Term: NEUTROPHILS; Subject Term: MOUTH -- Ulcers; Subject Term: SYNDROMES; Subject Term: ORAL diseases; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0714.ep11541125
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rölla, Gunnar
AU  - Little, Wayne A.
AU  - Ciardi, Joseph E.
T1  - Effect of antibody preparations on glucose uptake by a cariogenic streptococcus.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1985/02//
VL  - 93
IS  - 1
M3  - Article
SP  - 13
EP  - 16
SN  - 0029845X
AB  - The effect of antisera to whole cells or cell wall components on glucose uptake by S. mutans 6715 was examined. Early stationary phase 6715 cells were treated with test serum and incubated at 37°C in the presence of 14C-glucose. Samples were removed at timed intervals and measured in a liquid scintillation counter for radioactive uptake. Antisera to both whole cells and components known to be present on the surface of the cells reduced glucose uptake relative to normal serum. It is suggested that inhibition of glucose uptake may be one mechanism by which a caries vaccine may operate. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE serums
KW  - CELLS
KW  - IMMUNOGLOBULINS
KW  - GLUCOSE
KW  - STREPTOCOCCUS
KW  - DENTAL caries
KW  - antibodies
KW  - glucose uptake
KW  - S. mutans.
N1  - Accession Number: 13232494; Rölla, Gunnar 1,2 Little, Wayne A. 1,2 Ciardi, Joseph E. 1,2; Affiliation:  1: Department of Pedodontics, Dental Faculty, University of Oslo, Oslo, Norway  2: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 1985, Vol. 93 Issue 1, p13; Subject Term: IMMUNE serums; Subject Term: CELLS; Subject Term: IMMUNOGLOBULINS; Subject Term: GLUCOSE; Subject Term: STREPTOCOCCUS; Subject Term: DENTAL caries; Author-Supplied Keyword: antibodies; Author-Supplied Keyword: glucose uptake; Author-Supplied Keyword: S. mutans.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Albrecht, Gary L.
AU  - Jackson, David J.
T1  - The Social Context of Policy Research.
JO  - Sociological Methods & Research
JF  - Sociological Methods & Research
Y1  - 1985/02//
VL  - 13
IS  - 3
M3  - Article
SP  - 275
SN  - 00491241
AB  - Presents an introduction to the February 1985 issue of the periodical "Sociological Methods & Research".
KW  - SOCIOLOGICAL research
KW  - SOCIOLOGICAL Methods & Research (Periodical)
N1  - Accession Number: 5819275; Albrecht, Gary L. 1 Jackson, David J. 2; Affiliation:  1: University of Illinois, Chicago.  2: National Institute of Mental Health.; Source Info: Feb85, Vol. 13 Issue 3, p275; Subject Term: SOCIOLOGICAL research; Reviews & Products: SOCIOLOGICAL Methods & Research (Periodical); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tsujibo, Hiroshi
AU  - Tiano, Howard F.
AU  - Li, Steven S. -L.
T1  - Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1985/02/15/
VL  - 147
IS  - 1
M3  - Article
SP  - 9
EP  - 15
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Eight cDNA clones for lactate dehydrogenase-A isozyme (LDH-A) were isolated from a human fibroblast cDNA library, characterized, and no sequence heterogeneity was found. Four cDNA clones appear to contain nearly full-length cDNA inserts and the complete nucleotide sequence of 1710 base pairs consists of the protein-coding sequence (999 base pairs), the 5′ (97 base pairs) and 3′ (565 base pairs) untranslated regions and poly(dA) tail (49 base pairs). The predicted amino acid sequence of the human LDH-A polypeptide shows 92% homology (27 differences out of 331 amino acids compared) with that of the pig LDH-A subunit determined by direct protein sequencing [Kiltz et al. (1977) Hoppe-Seyler's Z. Physiol. Chem. 358, 123–127]. Human genomic clones containing an LDH-A pseudogene were isolated and the nucleotide sequence of 1635 base pairs from an intronless pseudogene was determined. The presence of two termination codons, two deletions of three nucleotides each and the replacement of three arginine residues at the active site (nos 98, 105 and 168) by other amino acids renders its coding region incapable of producing a functional LDH-A protein. A comparison between human LDH-A cDNA and the pseudogene sequences reveals 12.9% differences (114 transitions, 65 transversions and 36 deletions/ insertions). Further, only four out of the 25 dCpdG dinucleotides present in the eDNA sequence remain unchanged. although the sequences possess 87.1% homology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BINDING sites (Biochemistry)
KW  - DNA
KW  - NUCLEOTIDE sequence
KW  - NUCLEIC acids -- Analysis
KW  - LACTATE dehydrogenase
KW  - PROTEINS -- Analysis
KW  - NUCLEOTIDES
KW  - ARGININE
KW  - DEHYDROGENASES
N1  - Accession Number: 13817680; Tsujibo, Hiroshi 1 Tiano, Howard F. 1 Li, Steven S. -L. 1; Affiliation:  1: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; Source Info: 2/15/85, Vol. 147 Issue 1, p9; Subject Term: BINDING sites (Biochemistry); Subject Term: DNA; Subject Term: NUCLEOTIDE sequence; Subject Term: NUCLEIC acids -- Analysis; Subject Term: LACTATE dehydrogenase; Subject Term: PROTEINS -- Analysis; Subject Term: NUCLEOTIDES; Subject Term: ARGININE; Subject Term: DEHYDROGENASES; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - King, Haitung
AU  - Jun-Yao Li
AU  - Locke, Frances B.
AU  - Pollack, Earl S.
AU  - Ji-Tao Tu
T1  - Patterns of Site-Specific Displacement in Cancer Mortality among Migrants: The Chinese in the United States.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/03//
VL  - 75
IS  - 3
M3  - Article
SP  - 237
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Taking advantage of the information gathered for the 1975 National Mortality Survey in China. This paper compares the levels of cancer mortality among foreign-born and United Statesborn Chinese  around 1970 with   those  of the  communities of origin of the majority  of Chinese migrants to the US. Age-adjusted rated indicate two distinctive site-specific patterns among US Chinese: a downward trend for cancers of high risk among Guangdong and Hong Kong Chinese masopharynx, esophagus, liver, uterus, and perhaps stomach) and an upward trend for those sites of risk among Chinese in Guangdong and Hong Kong (colon, lung, leukemia, and female breast. Further field studies are needed with emphasis on the birthplace of migrants and environmental change in host countries. (Am J Public Health 1985: 75-237-242). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER -- Mortality
KW  - CANCER -- Etiology
KW  - CANCER -- Environmental aspects
KW  - CANCER patients
KW  - CHINESE -- United States
KW  - UNITED States
KW  - GUANGDONG Sheng (China)
KW  - HONG Kong Island (China)
KW  - CHINA
N1  - Accession Number: 4948552; King, Haitung 1,2,3,4 Jun-Yao Li 1,2,3,4 Locke, Frances B. 1,2,3,4 Pollack, Earl S. 1,2,3,4 Ji-Tao Tu 1,2,3,4; Affiliation:  1: National Cancer Institute.  2: Georgetown University.  3: Chinese Cancer Research Institute.  4: Shanghai Cancer Institute.; Source Info: Mar1985, Vol. 75 Issue 3, p237; Subject Term: CANCER -- Mortality; Subject Term: CANCER -- Etiology; Subject Term: CANCER -- Environmental aspects; Subject Term: CANCER patients; Subject Term: CHINESE -- United States; Subject Term: UNITED States; Subject Term: GUANGDONG Sheng (China); Subject Term: HONG Kong Island (China); Subject Term: CHINA; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lawrence, Charles E.
AU  - Reilly, Andrew A.
AU  - Quickenton, Phillip
AU  - Greenwald, Peter
AU  - Page, William F.
AU  - Kuntz, Amy J.
T1  - Mortality Patterns of New York State Vietnam Veterans.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/03//
VL  - 75
IS  - 3
M3  - Article
SP  - 277
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Mortality odds ratios (MORs) comparing veterans with Vietnam service who died in New York State to veterans of the Vietnam era with no Vietnam service were estimated (N - 1.496). The most elevated M()Rs and their confidence intervals were nonmotor vehicular injuries of transport (MOR = 2.18. (l. 19. 3.96}). other accidents and burns MOR = 1.37. 10.95. l.98)), and homicide (MOR = 1.59. (0.86. 2.94). (Am J Public Health 1985; 75:277-279.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MORTALITY -- Statistics
KW  - DEATH -- Causes
KW  - ACCIDENTS
KW  - DIOXINS
KW  - HERBICIDES -- Physiological effect
KW  - VIETNAM veterans
KW  - VIETNAM War, 1961-1975
KW  - PUBLIC health
KW  - NEW York (State)
N1  - Accession Number: 4948576; Lawrence, Charles E. 1 Reilly, Andrew A. 1 Quickenton, Phillip 1 Greenwald, Peter 2 Page, William F. 3 Kuntz, Amy J. 3; Affiliation:  1: New York State Department of Health.  2: National Cancer Institute.  3: Veterans Administration.; Source Info: Mar1985, Vol. 75 Issue 3, p277; Subject Term: MORTALITY -- Statistics; Subject Term: DEATH -- Causes; Subject Term: ACCIDENTS; Subject Term: DIOXINS; Subject Term: HERBICIDES -- Physiological effect; Subject Term: VIETNAM veterans; Subject Term: VIETNAM War, 1961-1975; Subject Term: PUBLIC health; Subject Term: NEW York (State); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levinson, Rachel E.
AU  - Stoto, Michael A.
T1  - SCIENCE AND POLICY: TIME FOR DIALOGUE.
JO  - BioScience
JF  - BioScience
Y1  - 1985/03//
VL  - 35
IS  - 3
M3  - Book Review
SP  - 185
EP  - 186
SN  - 00063568
AB  - Reviews the book 'Biomedical Institutions. Biomedical Funding, and Public Policy,' edited by H.H. Fudenberg.
KW  - Medical research
KW  - Nonfiction
KW  - Biomedical Institutions: Biomedical Funding & Public Policy (Book)
N1  - Accession Number: 10101061; Levinson, Rachel E. 1; Stoto, Michael A. 2; Affiliations: 1: National Institutes of Health; 2: Institute, of Medicine, National Academy of Sciences, 2101 Constitution Avenue, Washington, DC 20418; Issue Info: Mar1985, Vol. 35 Issue 3, p185; Subject Term: Medical research; Subject Term: Nonfiction; Reviews & Products: Biomedical Institutions: Biomedical Funding & Public Policy (Book); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 924
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Grusky, Oscar
AU  - Tierney, Kathleen
AU  - Manderscheid, Ronald W.
AU  - Grusky, David B.
T1  - Social Bonding and Community Adjustment of Chronically Mentally Ill Adults.
JO  - Journal of Health & Social Behavior
JF  - Journal of Health & Social Behavior
Y1  - 1985/03//
VL  - 26
IS  - 1
M3  - Article
SP  - 49
EP  - 63
SN  - 00221465
AB  - This study specifies, estimates, and discusses two models of social adjustment and service use among a national sample of chronically mentally ill adults (N = 971) who participated in the NIMH Community Support Program, a federal-state collaborative effort to assist severely mentally disabled adults to function outside institutions. The first model is a simple unidimensional social bonding model. The second, more complex model distinguishes between types of social bonding, social adjustment, and service use. This model fits substantially better than the first model and is consistent with a large body of current research. Community and work bonding showed strong positive relationships with personal and community adjustment, but the corresponding effects of family bonding are nonsignificant. In addition, the three types of social bonding affected service use differently. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTALLY ill
KW  - SOCIAL adjustment
KW  - SOCIAL interaction
KW  - COMMUNITY mental health services
KW  - MENTAL health services use
KW  - FAMILY relations
N1  - Accession Number: 12919589; Grusky, Oscar 1 Tierney, Kathleen 2 Manderscheid, Ronald W. 3 Grusky, David B. 4; Affiliation:  1: University of California, Los Angeles  2: Seismic Safety Commission, State of California  3: National Institute of Mental Health  4: University of Wisconsin, Madison; Source Info: Mar1985, Vol. 26 Issue 1, p49; Subject Term: MENTALLY ill; Subject Term: SOCIAL adjustment; Subject Term: SOCIAL interaction; Subject Term: COMMUNITY mental health services; Subject Term: MENTAL health services use; Subject Term: FAMILY relations; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 15p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Carson, Richard E.
AU  - Lange, Kenneth
T1  - A Statistical Model for Position Emission Tomography: Comment.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/03//
VL  - 80
IS  - 389
M3  - Article
SP  - 20
SN  - 01621459
AB  - The article presents comments of the author on the article "A Statistical Model for Positron Emission Tomography," by V. Vardi, I.A. Shepp and L. Kaufman. Positron emission tomography (EM) provides the capability to quantitatively measure the local concentration of a variety of radionuclides in humans and animals. This high-quality data can be used to elucidate subtleties of physiology and biochemistry in normal and diseased states. Accurate interpretation of the data depends upon quantitative image reconstruction methods combined with the techniques of tracer kinetic modeling. The EM algorithm for image reconstruction in positron emission tomography was first presented by Shepp and Vardi. Independently, authors developed EM algorithms for image reconstruction for emission and transmission tomography. The probability of an emission from pixel index being detected along projection line index are assumed to be known exactly and depend upon the physical factors affecting tomographic projection measurements: radioactive decay, projection sampling scheme, detector efficiency and location, spatial resolution, attenuation, scatter, accidental coincidences, positron range and angulation.
KW  - ALGORITHMS
KW  - PROBABILITY theory
KW  - EMISSION tomography
KW  - POSITRON emission
KW  - DETECTORS
KW  - RADIOACTIVE decay
N1  - Accession Number: 4610323; Carson, Richard E. 1; Lange, Kenneth 2; Affiliations: 1: Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD 20205.; 2: Department of Biomathematics, UCLA, Los Angeles, CA 90024.; Issue Info: Mar1985, Vol. 80 Issue 389, p20; Thesaurus Term: ALGORITHMS; Thesaurus Term: PROBABILITY theory; Subject Term: EMISSION tomography; Subject Term: POSITRON emission; Subject Term: DETECTORS; Subject Term: RADIOACTIVE decay; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Fredrikson, Mats
AU  - Danielssons, Tomas
AU  - Engel, Bernard T.
AU  - Frisk-Holmberg, Marianne
AU  - Strom, Gunnar
AU  - Sundin, Orjan
T1  - Autonomic Nervous System Function and Essential Hypertension: Individual Response Specificity With and Without Beta-Adrenergic Blockade.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1985/03//
VL  - 22
IS  - 2
M3  - Article
SP  - 167
EP  - 174
SN  - 00485772
AB  - The aim of the present research was to study individual response specificity in 22 male patients having essential hypertension (HT) and to compare these patients with age-matched male normotensive controls (NT). Four stimuli, letter identification, mental arithmetic, cold pressor and isometric exercise, were administered while recordings were made of: systolic and diastolic blood pressures, heart rate, respiration, forearm and hand blood flows, and skin conductance level and fluctuations. After each session urine samples were collected and epinephrine and norepinephrine levels were analyzed. Twelve subjects in the HT group were given beta-adrenergic blocking agents and retested 1 to 21 months (&Xbar; = 12 months) after the first session. Each response was standardized, using NT as the reference group. Intraclass correlations were computed to evaluate whether HT males reacted with a more consistent hierarchy of responses than did NT. Intraclass correlations were significantly higher among the patients than in the control group, regardless of whether the blood pressure response was included or excluded in the computation of the intraclass correlations. Thus, we conclude that male HT patients show more individual response specificity than NT controls. Beta-adrenergic receptor antagonists reduced levels of cardiovascular activity and attenuated reactivity but did not affect amount of specificity. Thus, intraclass correlations provide unique and useful information, since they are not related to blood pressure reactivity or to urinary catecholamine levels, nor affected by beta-adrenergic blockade. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTONOMIC nervous system
KW  - ESSENTIAL hypertension
KW  - BLOOD pressure
KW  - HEART beat
KW  - RESPIRATION
KW  - GALVANIC skin response
KW  - CATECHOLAMINES
KW  - Beta-adrenergic blocking
KW  - Blood flow
KW  - Blood pressure
KW  - Catecholamine
KW  - Electrodermal activity
KW  - Essential hypertension
KW  - Heart rate
KW  - Individual response specificity
KW  - Respiration
KW  - Response patterns.
N1  - Accession Number: 11026855; Fredrikson, Mats 1,2 Danielssons, Tomas 2 Engel, Bernard T. 3 Frisk-Holmberg, Marianne 2 Strom, Gunnar 2 Sundin, Orjan 2; Affiliation:  1: Department of Psychiatry and Psychology, Karolinska Institute, Stockholm. Sweden,  2: University Hospital, Uppsala Sweden.  3: Gerontology, Research Center National Institute on Aging Bethesda and Baltimore City Hospital.; Source Info: Mar1985, Vol. 22 Issue 2, p167; Subject Term: AUTONOMIC nervous system; Subject Term: ESSENTIAL hypertension; Subject Term: BLOOD pressure; Subject Term: HEART beat; Subject Term: RESPIRATION; Subject Term: GALVANIC skin response; Subject Term: CATECHOLAMINES; Author-Supplied Keyword: Beta-adrenergic blocking; Author-Supplied Keyword: Blood flow; Author-Supplied Keyword: Blood pressure; Author-Supplied Keyword: Catecholamine; Author-Supplied Keyword: Electrodermal activity; Author-Supplied Keyword: Essential hypertension; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Individual response specificity; Author-Supplied Keyword: Respiration; Author-Supplied Keyword: Response patterns.; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-8986.ep11026855
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson, Ray
AU  - Donchin, Emanuel
T1  - Second Thoughts: Multiple P300s Elicited by a Single Stimulus.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1985/03//
VL  - 22
IS  - 2
M3  - Article
SP  - 182
EP  - 194
SN  - 00485772
AB  - In a previous report (Johnson & Donchin, 1978), we manipulated the discriminability of tone pairs that delivered feedback information in a time-estimation paradigm. As in other experiments using feedback stimuli, the event-related potentials elicited by these stimuli did not return to baseline in the 800-ms poststimulus interval. Since we were interested in this "Slow Wave" activity, the poststimulus interval was lengthened to 1500 ms. Averages revealed that a second positive peak was present for some of the individual subjects. To investigate this activity further, the filtered single- trial waveforms were inspected visually. These data were characterized by the presence of one, and occasionally two, positive peaks, with highly variable latencies, following the P300. These peaks were indistinguishable in frequency and general appearance from the P300s elicited by the feedback stimuli, After latency adjusting the waveforms on the peak of the second positive wave, amplitude and latency were quantified. Whereas P300 amplitude was directly related to stimulus discriminability and positive feedback elicited larger P300s than negative feedback, the amplitude of the second positive wave was constant across levels of discriminability and the same for both types of feedback. In contrast, the latencies of both waves were inversely related to stimulus discriminability and shorter following positive feedback than negative feedback. Evidence is presented to support our contention that these additional positive peaks represent P300 activity. The data are discussed in terms of what these multiple P300s reveal about human information processing. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOKED potentials (Electrophysiology)
KW  - ELECTROPHYSIOLOGY
KW  - FEEDBACK (Psychology)
KW  - DECISION making
KW  - HUMAN information processing
KW  - PERCEPTION
KW  - Decision making.
KW  - Event-related potentials. P300
KW  - Feedback
N1  - Accession Number: 11026877; Johnson, Ray 1 Donchin, Emanuel 2; Affiliation:  1: The National Institutes of Health, NINCDS/Medical Neurology Branch, Bethesda, Maryland.  2: Cognitive Psychophysiology Laboratory, Depart meni of Psychology, University of Illinois, Champaign.; Source Info: Mar1985, Vol. 22 Issue 2, p182; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: ELECTROPHYSIOLOGY; Subject Term: FEEDBACK (Psychology); Subject Term: DECISION making; Subject Term: HUMAN information processing; Subject Term: PERCEPTION; Author-Supplied Keyword: Decision making.; Author-Supplied Keyword: Event-related potentials. P300; Author-Supplied Keyword: Feedback; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1469-8986.ep11026877
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eisenberg, Evan
AU  - Hill, Terrell L.
T1  - Muscle Contraction and Free Energy Transduction in Biological Systems.
JO  - Science
JF  - Science
Y1  - 1985/03//3/ 1/1985
VL  - 227
IS  - 4690
M3  - Article
SP  - 999
EP  - 1006
SN  - 00368075
N1  - Accession Number: 84692156; Eisenberg, Evan 1 Hill, Terrell L. 2; Affiliation:  1: Head of the Section on Cellular Physiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205  2: Head of the Section on Theoretical Molecular Biology, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20205; Source Info: 3/ 1/1985, Vol. 227 Issue 4690, p999; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - SAXINGER, W. CARL
AU  - LEVINE, PAUL H.
AU  - DEAN, A. G.
AU  - THE, GuY DE
AU  - LANGE-WANTZIN, GUNHILD
AU  - MOGHISSI, JASMINE
AU  - LAURENT, FRANCINE
AU  - HOH, MEI
AU  - SARNGADHARAN, M. G.
AU  - GALLO, ROBERT C.
T1  - Evidence for Exposure to HTLV-III in Uganda Before 1973.
JO  - Science
JF  - Science
Y1  - 1985/03//3/ 1/1985
VL  - 227
IS  - 4690
M3  - Article
SP  - 1036
EP  - 1038
SN  - 00368075
AB  - Fifty of 75 serum samples collected in the West Nile district of Uganda between August 1972 and July 1973 contained antibodies reactive with human T-cell leukemia (lymphotropic) virus type 3 (HTLV-Ill; mean titer, 601), while 12 of 75 samples were positive in a similar test for HTLV type I (HTLV-I) antibodies (mean titer, 236). The samples were screened by enzyme-linked immunosorbent assay and positive results were confirmed by a newly developed unlabeled antibody-peroxidase procedure with enhanced sensitivity for detection of antibody binding to immunoblots of HTLV-II antigen, demonstrating antibodies to proteins with molecular weights of 24,000, 41,000, and 76,000 in nearly all positive samples. Analysis of titration data indicated enhanced titers of antibody against HTLV-III and HTLV-I when coinfection occurred. The high prevalence and relatively low titers [compared to serum from patients with acquired immune deficiency syndrome (AIDS)] of antibodies recognizing HTLV-Ill proteins in sera from this population at a time that may predate or coincide with the appearance or spread of the AIDS agent (HTLVIII) suggest that the virus detected may have been a predecessor of HTLV-IlI or is HTLV-III itself but existing in a population acclimated to its presence. It further suggests an African origin of HTLV-III. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692179; SAXINGER, W. CARL 1 LEVINE, PAUL H. 2 DEAN, A. G. 3 THE, GuY DE 4 LANGE-WANTZIN, GUNHILD 5 MOGHISSI, JASMINE 6 LAURENT, FRANCINE 6 HOH, MEI 6 SARNGADHARAN, M. G. 6 GALLO, ROBERT C. 6; Affiliation:  1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205  2: Clinical Epidemiology Branch, National Cancer Institute  3: International Agency for Research in Cancer, Lyon, France  4: Laboratoire d'Epide6miologie et Immunovirologie des Tumeurs, Lyon, France  5: Bispebjerg Hospital, Copenhagen, Denmark  6: Laboratory of Tumor Cell Biology, National Cancer Institute; Source Info: 3/ 1/1985, Vol. 227 Issue 4690, p1036; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SCHMALJOHN, C. S.
AU  - HASTY, S. E.
AU  - DALRYMPLE, J. M.
AU  - LEDUC, J. W.
AU  - LEE, H. W.
AU  - BONSDORFF, C.-H. VON
AU  - BRUMMER-KORVENKONTIO, M.
AU  - VAHERI, A.
AU  - TSAI, T. F.
AU  - REGNERY, H. L.
AU  - GOLDGABER, D.
AU  - LEE, P. W.
T1  - Antigenic and Genetic Properties of Viruses Linked to Hemorrhagic Fever with Renal Syndrome.
JO  - Science
JF  - Science
Y1  - 1985/03//3/ 1/1985
VL  - 227
IS  - 4690
M3  - Article
SP  - 1041
EP  - 1044
SN  - 00368075
AB  - Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692181; SCHMALJOHN, C. S. 1 HASTY, S. E. 1 DALRYMPLE, J. M. 1 LEDUC, J. W. 1 LEE, H. W. 2 BONSDORFF, C.-H. VON 3 BRUMMER-KORVENKONTIO, M. 3 VAHERI, A. 3 TSAI, T. F. 4 REGNERY, H. L. 4 GOLDGABER, D. 5 LEE, P. W. 5; Affiliation:  1: Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701  2: Institute for Viral Diseases, Korea University College of Medicine, Seoul, Korea  3: Department of Virology, University of Helsinki, Helsinki, Finland  4: Viral Diseases Division, Centers for Disease Control, Atlanta, Georgia 30333  5: Laboratory of Central Nervous Studies, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20205; Source Info: 3/ 1/1985, Vol. 227 Issue 4690, p1041; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Krauze, Tadeusz
AU  - Slomczynski, Kazimierz M.
T1  - How Far to Meritocracy? Empirical Tests of a Controversial Thesis.
JO  - Social Forces
JF  - Social Forces
Y1  - 1985/03//
VL  - 63
IS  - 3
M3  - Article
SP  - 623
EP  - 642
PB  - Oxford University Press / USA
SN  - 00377732
AB  - Abstract  The meritocratic thesis states that a strong association between individual "merit" and social rewards is inherent in highly industrialized society. A simple model of meritocratic allocation is proposed and applied to provide empirical assessment of "how far to meritocracy?" from empirical reality. The model, conceptualized as an ideal type of meritocracy, incorporates the principle according to which more educated persons do not have lower status than less educated ones. Assuming that a meritocratic society should resemble its ideal type, we have formulated three testable hypotheses involving status mobility within educational groups, status determination by education, and status inequality among educational groups. The tests consist of evaluating the discrepancies between the data on the U.S. total labor force and the model. All three hypotheses implying that American society is close to meritocracy are rejected. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TECHNOCRACY
KW  - EDUCATION
KW  - SOCIAL status
KW  - EQUALITY
KW  - LABOR supply
KW  - UNITED States
N1  - Accession Number: 5281777; Krauze, Tadeusz 1 Slomczynski, Kazimierz M. 2,3; Affiliation:  1: Hofstra University  2: University of Warsaw  3: National Institute of Mental Health; Source Info: Mar85, Vol. 63 Issue 3, p623; Subject Term: TECHNOCRACY; Subject Term: EDUCATION; Subject Term: SOCIAL status; Subject Term: EQUALITY; Subject Term: LABOR supply; Subject Term: UNITED States; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 20p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06422-032
AN  - 2006-06422-032
AU  - Wolfe, Barry E.
T1  - The Temporary Accommodation of Eclecticism.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1985/03//
VL  - 30
IS  - 3
SP  - 223
EP  - 224
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06422-032. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wolfe, Barry E.; Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Counseling; Eclectic Psychotherapy; Therapeutic Processes. Minor Descriptor: Therapists. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Hart, Joseph. Modern Eclectic Therapy: A Functional Orientation to Counseling and Psychotherapy. Including a Twelve-Month Manual for Therapists=New York: Plenum Press, 1983. 404 pp. $37.50; 1983. References Available: Y. Page Count: 2. Issue Publication Date: Mar, 1985. 
AB  - Reviews the book, Modern Eclectic Therapy: A Functional Orientation to Counseling and Psychotherapy. Including a Twelve-Month Manual for Therapists by Joseph Hart (1983). Tha author's book presents what he believes to be a comprehensive theoretical framework applicable to most therapists and all patients. The most useful section of the book is the manual that the author developed for his therapy. As a statement of one man's therapeutic eclecticism, this book is a useful and interesting document. The author has gone to some pains to systematize his programmatic, action-oriented therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - eclectic therapy
KW  - functional orientation
KW  - counseling
KW  - psychotherapy
KW  - therapeutic eclecticism
KW  - 1985
KW  - Counseling
KW  - Eclectic Psychotherapy
KW  - Therapeutic Processes
KW  - Therapists
KW  - 1985
U2  - Hart, Joseph. (1983); Modern Eclectic Therapy: A Functional Orientation to Counseling and Psychotherapy. Including a Twelve-Month Manual for Therapists; New York: Plenum Press, 1983. 404 pp. $37.50
DO  - 10.1037/023648
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Krohn, K.
AU  - Ranki, Annamarj
AU  - Antonen, J.
AU  - Valle, Sirka-Lijsa
AU  - Suni, J.
AU  - Saxinger, C.
AU  - Gallo, R. C.
T1  - Immune functions in homosexual men with antibodies to HTLV-III in Finland.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1985/04//
VL  - 60
IS  - 1
M3  - Article
SP  - 17
EP  - 24
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The occurrence of HTLV-III anbbodies in a voluntary group of 175 homosexual men in a low risk AIDS area was studied, and the findings were correlated to clinical, virological immunological and lifestyle parameters Fifteen of 175 men had HTLV-III antibodies: two of these had AIDS, five had LAS and two had enlarged lymph nodes. In the HTLV-III antibody negative group, no signs of AIDS or pre-AIDS were seen during a 10 month follow-up. In HTLV-III antibody positive individuals, low THTS ratio was mainly due to decreased number of TS cogs Most HTLV-III antibody positive cases had low responses In a specific antigen. PPD while responses to the mitogens PHA and PWM were only slightly affected. In HTLV-III antibody negative cases, 13% had a low TH/TS ratio, mostly due to elevation of Ts cells. In this group, mitogen and antigen responses were normal or only slightly affected. The results reinforce the causal relationship between HTLV-III and AIDS and suggest that the cells primarily affected by the virus infection are TH cells, responsible tot antigen specific responses Longitudinal studies are required to find out, what is the relationship of immune response to the development of clinical AIDS in HTLV-III infected individuals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - GAY people
KW  - IMMUNOGLOBULINS
KW  - HIV (Viruses)
KW  - LYMPH nodes
KW  - IMMUNOLOGY
KW  - LYMPHATICS
KW  - AIDS
KW  - helper T cells
KW  - HTLV-III infection
KW  - suppressor T cells
N1  - Accession Number: 15961196; Krohn, K. 1 Ranki, Annamarj 2 Antonen, J. 1 Valle, Sirka-Lijsa 2 Suni, J. 3,4 Saxinger, C. 5 Gallo, R. C. 5; Affiliation:  1: Institute of Biomedical Sciences, University of Tampere, Tampere.  2: Department of Dermatology and Venerology, Helsinki University Central Hospital.  3: Department of Virology, Helsinki University.  4: Aurora Microbiological Laboratory, Helsinki, Finland.  5: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Apr1985, Vol. 60 Issue 1, p17; Subject Term: IMMUNE response; Subject Term: GAY people; Subject Term: IMMUNOGLOBULINS; Subject Term: HIV (Viruses); Subject Term: LYMPH nodes; Subject Term: IMMUNOLOGY; Subject Term: LYMPHATICS; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: helper T cells; Author-Supplied Keyword: HTLV-III infection; Author-Supplied Keyword: suppressor T cells; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Handwerger, B. S.
AU  - Fernandes, G.
AU  - Riehm, Terri
AU  - Yoon, J.-W.
AU  - Sutherland, D. E. R.
AU  - Brown, D. M.
T1  - Alterations in immunological reactivity in encephalomyocarditis virus-induced murine diabetes. I. Defective primary IgM plaque forming cell responses to sheep erythrocytes: correction by islet cell transplantation.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1985/04//
VL  - 60
IS  - 1
M3  - Article
SP  - 145
EP  - 150
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Increasing data suggest a possible viral aetiology of juvenile onset, insulin-dependent diabetes mellitus. The M variant of the encephalomyocarditis (EMC) virus infects murine pancreatic beta cells and causes a diabetes like syndrome in susceptible strains of mice. Abnormalities in immunological function have been documented in patients with diabetes mellitus and in spontaneous. streptozotocin-induced and alloxan-induced diabetes in animals. The present study documents a significant impairment of the ability of mice with EMC virus (M variant)-induced diabetes to generate a direct. IgM PFC response after in vivo immunization with sheep erythrocytes. This abnormality appears to be a direct consequence of the diabetic state and not EMC virus infection, per se, since (1) mice infected with EMC virus that do not become diabetic have normal direct PEC responses and (2) islet cell transplantation, which cures the diabetes. corrects the defect in PFC responsiveness. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIABETES
KW  - IMMUNOGLOBULIN M
KW  - CELLS
KW  - ERYTHROCYTES
KW  - CARBOHYDRATE intolerance
KW  - PANCREATIC beta cells
KW  - IMMUNIZATION
KW  - diabetes
KW  - EMC virus
KW  - immunity
N1  - Accession Number: 15961599; Handwerger, B. S. 1,2,3 Fernandes, G. 4 Riehm, Terri 2 Yoon, J.-W. 5 Sutherland, D. E. R. 5 Brown, D. M. 3; Affiliation:  1: Rheumatology Research Unit and Departments of Medicine and Immunology, Mayo Clinic/Foundation, Rochester, Minnesota.  2: Research and Medical Services, Veterans Administration Center, Minneapolis.  3: Departments of Medicine and Microbiology, Surgery, Pediatrics and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.  4: Division of Clinical Immunology and Arthritis, Department of Medicine, University of Texas, San Antonio, Texas.  5: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1985, Vol. 60 Issue 1, p145; Subject Term: DIABETES; Subject Term: IMMUNOGLOBULIN M; Subject Term: CELLS; Subject Term: ERYTHROCYTES; Subject Term: CARBOHYDRATE intolerance; Subject Term: PANCREATIC beta cells; Subject Term: IMMUNIZATION; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: EMC virus; Author-Supplied Keyword: immunity; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zick, Yehiel
AU  - Grunberger, George
AU  - Rees-Jones, Robert W.
AU  - Comi, Richard J.
T1  - 182Use of tyrosine-containing polymers to characterize the substrate specificity of insulin and other hormone-stimulated tyrosine kinases.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1985/04//4/1/85
VL  - 148
IS  - 1
M3  - Article
SP  - 177
EP  - 182
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Synthetic copolymers containing tyrosine residues were used to characterize the substrate specificity of the insulin receptor kinase and compare it to tyrosine kinases stimulated by epidermal growth factor, insulin-like growth factor-1 and phorbol ester. In partially purified receptor preparations from eight different tissues insulin best stimulated (highest V) phosphorylation of a random copolymer composed of glutamic and tyrosine residues at a 4:1 ratio (Glu/Tyr; 4:1). The insulin-stimulated phosphorylation of this polymer was highly significant also in receptor preparations from fresh human monocytes, where insulin binding and autophosphorylation were difficult to detect. Other tyrosine-containing polymers Ala/Glu/Lys/Tyr (6:2:5:1) and Glu/Ala/Tyr (6:3:1) were also phosphorylated by the insulin-stimulated kinase but to a lower extent. A tyrosine kinase stimulated by insulin-like growth factor-1, and one stimulated by phorbol ester also best phosphorylated the polymer Glu/Tyr (4:1). The three kinases differed only in their capability to phosphorylate Glu/Ala/Tyr (6:3:1) or Ala/Glu/Lys/Tyr (6:2:5:1). Glu/Tyr (4:1) was a poor substrate for the epidermal growth factor receptor kinase which best phosphorylated the polymer Glu/Ala/Tyr (6:3:1). Three additional polymers: Glu/Tyr (1:1), Glu/Ala/Tyr (1:1:1), and Lys/Tyr (1:1) failed to serve as substrates for all four tyrosine kinases tested. Taken together these findings suggest that. (a) Hormone-sensitive tyrosine kinases have similar yet distinct substrate specificity and are likely to phosphorylate their native substrates on tyrosines adjacent to acidic (glutamic) residues. (b) Tyrosine-containing polymer substrates are highly sensitive and convenient tools to study (hormone-sensitive) tyrosine kinases whose native substrates are unknown or present at low concentrations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN-tyrosine kinase
KW  - EPIDERMAL growth factor
KW  - POLYMERS
KW  - HORMONES
KW  - PHOSPHORYLATION
KW  - GLUTAMIC acid
N1  - Accession Number: 13854349; Zick, Yehiel 1 Grunberger, George 2 Rees-Jones, Robert W. 2 Comi, Richard J. 2; Affiliation:  1: Department of Chemical Immunology, Weizmann Institute of Science, P.O. Box 26, IL-76-100 Rehovot, Israel  2: Diabetes Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20205; Source Info: 4/1/85, Vol. 148 Issue 1, p177; Subject Term: PROTEIN-tyrosine kinase; Subject Term: EPIDERMAL growth factor; Subject Term: POLYMERS; Subject Term: HORMONES; Subject Term: PHOSPHORYLATION; Subject Term: GLUTAMIC acid; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rolla, Gunnar
AU  - Aamdal#Scheje, Anne
AU  - Ciardi, Joseph E.
T1  - Role of sucrose in plaque formation.
JO  - Scandinavian Journal of Dental Research
JF  - Scandinavian Journal of Dental Research
Y1  - 1985/04//
VL  - 93
IS  - 2
M3  - Article
SP  - 105
EP  - 111
SN  - 0029845X
AB  - Results arc presented which support the concept that the bacterial enzyme glucosyltransferase (GTF) plays a crucial role in sucrose induced plaque formation. GTF was shown to adhere strongly to anionic, hydrophobic and polysaccharide solid materials, and to be able to produce glucans in the adsorbed state. It appears conceivable that GTF adsorb to teeth and produce glucans. Glucan chains on the surface of the bacteria and glucans on the tooth surfaces interact (pack) and form a strong binding mechanism. The rigid α1,3 linked glucans produced by Streptococcus mutans are particularly suited for interaction of this kind. This mechanism could account for sucrose-induced binding of bacteria to enamel, pellicle covered enamel and preformed plaque. S. mutans would adhere particularly strongly to tooth surfaces in the presence of sucrose, according to this model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SUCROSE
KW  - DENTAL plaque
KW  - GLYCOSYLTRANSFERASES
KW  - POLYSACCHARIDES
KW  - GLUCANS
KW  - DENTAL enamel
KW  - dental caries
KW  - dental plaque
KW  - glucosyl transfcrase.
KW  - sucrose
N1  - Accession Number: 13234608; Rolla, Gunnar 1 Aamdal#Scheje, Anne 2 Ciardi, Joseph E. 2; Affiliation:  1: Dental Faculty, University of Oslo, Norway.  2: National Institute of Dental Research, National Institutes of Health, Bethesda. Maryland, USA.; Source Info: 1985, Vol. 93 Issue 2, p105; Subject Term: SUCROSE; Subject Term: DENTAL plaque; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: POLYSACCHARIDES; Subject Term: GLUCANS; Subject Term: DENTAL enamel; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: glucosyl transfcrase.; Author-Supplied Keyword: sucrose; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2013-42007-010
AN  - 2013-42007-010
AU  - Susman, Elizabeth J.
AU  - Trickett, Penelope K.
AU  - Iannotti, Ronald J.
AU  - Hollenbeck, Barbara E.
AU  - Zahn-Waxler, Carolyn
T1  - Child-rearing patterns in depressed, abusive, and normal mothers.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1985/04//
VL  - 55
IS  - 2
SP  - 237
EP  - 251
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
AD  - Zahn-Waxler, Carolyn, Laboratory of Developmental Psychology, National Institute of Mental Health, Bldg. 1 5K . 9000 Rockville Pike, Bethesda, MD, US, 20205
N1  - Accession Number: 2013-42007-010. PMID: 3993753 Partial author list: First Author & Affiliation: Susman, Elizabeth J.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aspiration Level; Childrearing Practices; Emotional Control; Mothers; Separation Individuation. Classification: Behavior Disorders & Antisocial Behavior (3230); Childrearing & Child Care (2956). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Schedule for Affective Disorders and Schizophrenia-Lifetime; Block Q-sort Instrument; Child-Rearing Practices Report DOI: 10.1037/t00815-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Apr, 1985. Copyright Statement: American Orthopsychiatric Association, Inc. 1985. 
AB  - Child-rearing patterns in relation to discipline, emotion regulation, separation-individuation, and level of aspiration differentiated depressed, abusive, and normal mothers. Depressed and abusive mothers both expressed inconsistency, hostility, and protectiveness. Both groups used anxiety and guilt inducing methods but only abusive mothers used them in conjunction with harsh authoritarian practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child-rearing patterns
KW  - abusive mothers
KW  - emotion regulation
KW  - guilt inducing methods
KW  - 1985
KW  - Aspiration Level
KW  - Childrearing Practices
KW  - Emotional Control
KW  - Mothers
KW  - Separation Individuation
KW  - 1985
DO  - 10.1111/j.1939-0025.1985.tb03438.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - DEFEO-JONES, DEBORAH
AU  - TATCHELL, KELLY
AU  - ROBINSON, Lucy C.
AU  - SIGAL, IRVING.S.
AU  - VASS, WILLIAM C.
AU  - LOWY, DOUGLAS R.
AU  - SCOLNICK, EDWARD M.
T1  - Mammalian and Yeast ras Gene Products: Biological Function in Their Heterologous Systems.
JO  - Science
JF  - Science
Y1  - 1985/04/12/
VL  - 228
IS  - 4696
M3  - Article
SP  - 179
EP  - 184
SN  - 00368075
AB  - Activated versions of ras genes have been found in various types of malignant tumors. The normal versions of these genes are found in organisms as diverse as mammals and yeasts. Yeast cells that lack their functional ras genes, RASsc-J and RASsc-2, are ordinarily nonviable. They have now been shown to remain viable if they carry a mammalian rasH gene. In addition, yeast-mammalian hybrid genes and a deletion mutant yeast RASsc-J gene were shown to induce morphologic transformation of mouse NIH 3T3 cells when the genes had a point mutation analogous to one that increases the transforming activity of mammalian ras genes. The results establish the functional relevance of the yeast system to the genetics and biochemistry of cellular transformation induced by mammalian ras genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692224; DEFEO-JONES, DEBORAH 1 TATCHELL, KELLY 2 ROBINSON, Lucy C. 2 SIGAL, IRVING.S. 3 VASS, WILLIAM C. 4 LOWY, DOUGLAS R. 4 SCOLNICK, EDWARD M. 3; Affiliation:  1: Department of Virus and Cell Biology, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486  2: Department of Biology, G5, University of Pennsylvania, Philadelphia 19104  3: Department of Virus and Cell Biology, Merck Sharp & Dohme Research Laboratories  4: Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20205; Source Info: 4/12/1985, Vol. 228 Issue 4696, p179; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sandler, Dale P.
AU  - Everson, Richard B.
AU  - Wilcox, Allen J.
AU  - Browder, James P.
T1  - Cancer Risk in Adulthood from Early Life Exposure to Parents' Smoking.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/05//
VL  - 75
IS  - 5
M3  - Article
SP  - 487
EP  - 492
PB  - American Public Health Association
SN  - 00900036
AB  - We obtained data on smoking by parents from 438 cancer cases nd 470 controls to investigate whether cancer risk in adult life is related to transplacental or childhood exposure to cigarette smoke. Cancer cases were between ages 15 and 59 at time of diagnosis. All 'sites but basal cell cancer of the skin were included. Cancer risk was increased 50 per cent among offspring of men who smoked, increased risk associated with father's smoking was not explained by demographic factors social class, or individual smoking habits and was not limited to known smoking related sites. Relative risk (RR) estimates associated with father's smoking tended to be greatest for smokers, males, and non-Whites. There was only a slight increase in overall cancer risk associated with maternal smoking. Mother's and father's smoking were both associated with risk for hematopoietic cancers, and a dose-response relationship was seen. The RR for hematopoietic cancers increased flora 1.7 when one parent smoked to 4.6 when both parents smoked. Although they should be considered tentative study findings suggest a long-term hazard from transplacental or childhood passive exposure to cigarette smoke. (Am J Public Health 1985: 75:487-492.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER patients
KW  - CIGARETTE smokers
KW  - DISEASES
KW  - OLDER people
KW  - PARENTS
KW  - SMOKING
KW  - SYMPTOMS
KW  - HEMATOPOIETIC system
KW  - HEMATOPOIESIS
N1  - Accession Number: 4949286; Sandler, Dale P. 1 Everson, Richard B. 2 Wilcox, Allen J. 2 Browder, James P. 3; Affiliation:  1: Epidemiology Branch, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Mail Drop A3-02. P.O. Box 12233, Research Triangle Park, NC 27709.  2: National Institute of Environmental Health Sciences.  3: Department of Surgery, School of Medicine, University of North Carolina, Chapel Hill.; Source Info: May85, Vol. 75 Issue 5, p487; Subject Term: CANCER patients; Subject Term: CIGARETTE smokers; Subject Term: DISEASES; Subject Term: OLDER people; Subject Term: PARENTS; Subject Term: SMOKING; Subject Term: SYMPTOMS; Subject Term: HEMATOPOIETIC system; Subject Term: HEMATOPOIESIS; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eto, Hikaru
AU  - Hashimoto, Ken
AU  - Kobayashi, Hitoshi
AU  - Matsumoto, Mitsuhiro
AU  - Kanzaki, Tamotsu
AU  - Mehregan, Amir H.
AU  - Weiss, Robert A.
T1  - Monoclonal Antikeratin Antibody: Production, Characterization, and Immunohistochemical Application.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/05//
VL  - 84
IS  - 5
M3  - Article
SP  - 404
EP  - 409
SN  - 0022202X
AB  - A monoclonal antikeratin antibody, EKH4, was produced from a hybridoma cell line which was established by fusing P3X63SAg8 mouse myeloma cells with spleen cells of mice immunized with human trichilemmoma cells. Immunoblot analysis showed that EKH4 antibody reacts predominantly with 50 kilodalton keratin polypeptide in normal epidermis. By indirect immunofluorescence and immunoperoxidase techniques, EKH4 antibody reacted with the lower 2-3 cell layers of the epidermis as well as most cells of pilosebaceous follicle of human and animal skin. Tumor cells of human basal cell epitheliomas and squamous cell carcinomas were also stained with this antibody. The staining was much more regular and intense compared with an available monoclonal antikeratin antibody, AE1. In the lesion of epidermal proliferative disorders, such as psoriasis and actinic keratosis, the entire epidermis instead of the lower layers was stained with EKH4 antibody. Normal skin overlying or adjacent to epithelial tumors also showed positive staining in the entire epidermis. By using indirect immunoperoxidase technique, EKH4 also stained alcohol-fixed, paraffin-embedded tissue sections. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - CELL lines
KW  - SPLEEN
KW  - MICE as laboratory animals
KW  - IMMUNOFLUORESCENCE
KW  - SQUAMOUS cell carcinoma
KW  - BASAL cell carcinoma
KW  - PSORIASIS
N1  - Accession Number: 12265506; Eto, Hikaru 1,2 Hashimoto, Ken 1,2 Kobayashi, Hitoshi 1,2 Matsumoto, Mitsuhiro 1,2 Kanzaki, Tamotsu 1,2 Mehregan, Amir H. 1,2 Weiss, Robert A. 3; Affiliation:  1: Department of Dermatology and Syphilology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A.  2: Research Service, Veterans Administration Medical Center, Allen Park, Michigan, U.S.A.  3: Dermatology Branch of the National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May85, Vol. 84 Issue 5, p404; Subject Term: MONOCLONAL antibodies; Subject Term: CELL lines; Subject Term: SPLEEN; Subject Term: MICE as laboratory animals; Subject Term: IMMUNOFLUORESCENCE; Subject Term: SQUAMOUS cell carcinoma; Subject Term: BASAL cell carcinoma; Subject Term: PSORIASIS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12265506
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - TAYLOR, PHILIP A.
AU  - GARRICK, NANCY A.
AU  - TAMARKIN, LAWRENCE
AU  - MURPHY, DENNIS L.
AU  - MARKEY, SANFORD P.
T1  - Diurnal Rhythms of N-Acetylserotonin and Serotonin in Cerebrospinal Fluid of Monkeys.
JO  - Science
JF  - Science
Y1  - 1985/05/17/
VL  - 228
IS  - 4701
M3  - Article
SP  - 900
EP  - 900
SN  - 00368075
N1  - Accession Number: 84692299; TAYLOR, PHILIP A. 1 GARRICK, NANCY A. 2 TAMARKIN, LAWRENCE 2 MURPHY, DENNIS L. 2 MARKEY, SANFORD P. 2; Affiliation:  1: MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh EH3 9EW, Scotland  2: National Institute of Mental Health, Bethesda, Maryland 20205; Source Info: 5/17/1985, Vol. 228 Issue 4701, p900; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Young, James F.
AU  - Hockmeyer, Wayne T.
AU  - Gross, Mitchell
AU  - Ballou, W. Ripley
AU  - Wirtz, Robert A.
AU  - Trosper, James H.
AU  - Beaudoin, Richard L.
AU  - Hollingdale, Michael R.
AU  - Miller, Louis H.
AU  - Diggs, Carter L.
AU  - Rosenberg, Martin
T1  - Expression of Plasmodium falciparum Circumsporozoite Proteins in Escherichia coli for Potential Use in a Human Malaria Vaccine.
JO  - Science
JF  - Science
Y1  - 1985/05/24/
VL  - 228
IS  - 4702
M3  - Article
SP  - 958
EP  - 962
SN  - 00368075
AB  - The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequencefound in the, CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692309; Young, James F. 1 Hockmeyer, Wayne T. 2 Gross, Mitchell 1 Ballou, W. Ripley 2 Wirtz, Robert A. 3 Trosper, James H. 4 Beaudoin, Richard L. 4 Hollingdale, Michael R. 5 Miller, Louis H. 6 Diggs, Carter L. 2 Rosenberg, Martin 1; Affiliation:  1: Department of Molecular Genetics, Smith Kline and French Laboratories, Philadelphia, Pennsylvania 19101  2: Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307  3: Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20307  4: Malaria Branch, Infectious Diseases Program Center, Naval Medical Research Institute, Bethesda, Maryland 20014  5: Biomedical Research Institute, Rockville, Maryland 20852  6: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Source Info: 5/24/1985, Vol. 228 Issue 4702, p958; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BALLOU, W. RIPLEY
AU  - ROTHDARD, JONATHAN
AU  - WIRTZ, ROBERT A.
AU  - GORDON, DANIEL M.
AU  - WILLIAMS, JOSEPH S.
AU  - GORE, RUFUS W.
AU  - SCHNEIDER, IMOGENE
AU  - HOLLINGDALE, MICHAEL R.
AU  - BEAUDOIN, RICHARD L.
AU  - MALOY, W. LEE
AU  - HOCKMEYER, WAYNE T.
T1  - Immunogenicity of Synthetic Peptides from Circumsporozoite Protein of Plasmodium falciparum.
JO  - Science
JF  - Science
Y1  - 1985/05/24/
VL  - 228
IS  - 4702
M3  - Article
SP  - 996
EP  - 999
SN  - 00368075
AB  - In a study of recombinant proteins that might be useful in developing a vaccine against malaria, synthetic peptides from the circumsporozoite (CS) protein of Plasmodium falciparum were found to be immunogenic for mice and rabbits. Antibody to peptides from the repeating region of the CS protein recognized native CS protein and blocked sporozoite invasion of human hepatoma cells in vitro. Antibodies to peptides from regions I and II had no biologic activity, although antibody to region I recognized processed CS protein by Western blot analysis. These data support the feasibility of developing a vaccine against the sporozoite stage of the malaria parasite by using synthetic peptides of the repeating region of the CS protein conjugated to a carrier protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692329; BALLOU, W. RIPLEY 1 ROTHDARD, JONATHAN 2 WIRTZ, ROBERT A. 3 GORDON, DANIEL M. 4 WILLIAMS, JOSEPH S. 4 GORE, RUFUS W. 4 SCHNEIDER, IMOGENE 3 HOLLINGDALE, MICHAEL R. 5 BEAUDOIN, RICHARD L. 6 MALOY, W. LEE 7 HOCKMEYER, WAYNE T. 4; Affiliation:  1: Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307  2: Department of Microbiology, Staford University Medical School, Palo Alto, California 94305  3: Department of Entomology, Walter Reed Army Institute of Research  4: Department of Immunology, Walter Reed Army Institute of Research  5: Biomedical Research Institute, Rockville Maryland 20852  6: Malaria Branch, Infectious Disease Program Center, Naval Medical Research Institute, Bethesda Maryland 20014  7: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases; Source Info: 5/24/1985, Vol. 228 Issue 4702, p996; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Collings, Bruce J.
AU  - Margolin, Barry H.
T1  - Testing Goodness of Fit for the Poisson Assumption When Observations Are Not Identically Distributed.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/06//
VL  - 80
IS  - 390
M3  - Article
SP  - 411
SN  - 01621459
AB  - Tests for detecting negative binomial departures from a Poisson model are studied for the one-way-layout and regression-through-the-origin cases. Approximations to the null and alternative distributions of these test statistics are presented. Locally optimal tests and tests suggested in the literature are compared in terms of asymptotic relative efficiency. Small sample comparisons are included. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MATHEMATICAL optimization
KW  - REGRESSION analysis
KW  - APPROXIMATION theory
KW  - STATISTICS
KW  - BINOMIAL distribution
KW  - NEGATIVE binomial distribution
KW  - POISSON distribution
KW  - POISSON processes
KW  - ASYMPTOTIC efficiencies (Statistics)
KW  - Binomial
KW  - Locally optimal tests
KW  - Negative binomial
KW  - One-way layout
KW  - Poisson
KW  - Regression through the origin.
N1  - Accession Number: 4614463; Collings, Bruce J. 1; Margolin, Barry H. 2; Affiliations: 1: Assistant Professor of Statistics, Department of Mathematical Sciences, Montana State University, Bozeman, MT 59717.; 2: Mathematical Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Jun85, Vol. 80 Issue 390, p411; Thesaurus Term: MATHEMATICAL optimization; Thesaurus Term: REGRESSION analysis; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: NEGATIVE binomial distribution; Subject Term: POISSON distribution; Subject Term: POISSON processes; Subject Term: ASYMPTOTIC efficiencies (Statistics); Author-Supplied Keyword: Binomial; Author-Supplied Keyword: Locally optimal tests; Author-Supplied Keyword: Negative binomial; Author-Supplied Keyword: One-way layout; Author-Supplied Keyword: Poisson; Author-Supplied Keyword: Regression through the origin.; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Parke, Robert
T1  - State and Metropolitan Area Data (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/06//
VL  - 80
IS  - 390
M3  - Book Review
SP  - 480
SN  - 01621459
AB  - Reviews the book "State and Metropolitan Area Data: 1982."
KW  - STATISTICS
KW  - UNITED States
KW  - NONFICTION
KW  - STATE & Metropolitan Area Data Book: 1982 (Book)
N1  - Accession Number: 4614637; Parke, Robert 1; Affiliations: 1: National Cancer Institute; Issue Info: Jun85, Vol. 80 Issue 390, p480; Thesaurus Term: STATISTICS; Subject Term: UNITED States; Subject Term: NONFICTION; Reviews & Products: STATE & Metropolitan Area Data Book: 1982 (Book); Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Miller, Karen A.
AU  - Kohn, Melvin L.
AU  - Schooler, Carmi
T1  - Education Self-Direction and the Cognitive Functioning of Students.
JO  - Social Forces
JF  - Social Forces
Y1  - 1985/06//
VL  - 63
IS  - 4
M3  - Article
SP  - 923
EP  - 944
PB  - Oxford University Press / USA
SN  - 00377732
AB  - Abstract  This paper reports an analysis of data from a small but substantially representative nationwide sample of white students in seventh grade through college. We propose and measure a concept, educational self-direction, by which we mean the use of initiative, thought, and independent judgment in schoolwork. Reciprocal-effects causal models show that the degree of educational self-direction exercised by students, in particular the substantive complexity of their schoolwork, has a decided impact on their cognitive functioning. Cognitive functioning, in turn, affects the exercise of educational self-direction. Separate models for secondary-school and college students confirm these findings at both educational levels. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTONOMY (Psychology)
KW  - DEPENDENCY (Psychology)
KW  - COGNITIVE ability
KW  - ABILITY
KW  - STUDENTS
KW  - SOCIAL psychology
N1  - Accession Number: 5283466; Miller, Karen A. 1,2 Kohn, Melvin L. 1 Schooler, Carmi 1; Affiliation:  1: National Institute of Mental Health.  2: Arizona State University.; Source Info: Jun85, Vol. 63 Issue 4, p923; Subject Term: AUTONOMY (Psychology); Subject Term: DEPENDENCY (Psychology); Subject Term: COGNITIVE ability; Subject Term: ABILITY; Subject Term: STUDENTS; Subject Term: SOCIAL psychology; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2007-12271-025
AN  - 2007-12271-025
AU  - Ragland, Sherman L.
T1  - Current issues regarding citizen participation in mental health services for minority groups.
T3  - Psychotherapy with Ethnic Minorities
JF  - Psychotherapy: Theory, Research, Practice, Training
JO  - Psychotherapy: Theory, Research, Practice, Training
JA  - Psychotherapy (Chic)
Y1  - 1985///Sum 1985
VL  - 22
IS  - 2S
SP  - 477
EP  - 478
CY  - US
PB  - Division of Psychotherapy (29), American Psychological Association
SN  - 0033-3204
SN  - 1939-1536
N1  - Accession Number: 2007-12271-025. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research & Practice. Partial author list: First Author & Affiliation: Ragland, Sherman L.; National Institute of Mental Health, US. Other Publishers: Educational Publishing Foundation. Release Date: 20070813. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Involvement; Community Mental Health Centers; Health Care Delivery; Mental Health Services; Minority Groups. Minor Descriptor: Volunteers. Classification: Community & Social Services (3373). Population: Animal (20). Location: US. References Available: Y. Page Count: 2. Issue Publication Date: Sum 1985. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1985. 
AB  - Volunteer citizen participation has long been recognized as a basic feature of the American character. Community involvement has long been the major strength of the Community Mental Health Program and was intended primarily to assure responsiveness. In addition to responsiveness it also assures accountability. One of the most effective ways to ensure that minorities are receiving adequate mental health services is to have them represented on boards of agencies that deliver those services. The community mental health center (CMHC) must be familiar with the social and political structure of the community, develop mutual trust between the professional and community spokesperson, and guarantee the cooperation of community leaders. The board of the CMHC must develop networks of community service. Board participation bridges the gap between the professional and the community. This is valuable for the mental health professionals who want input into the community, its leadership, institutions, and behavioral patterns. It is also important for the clients and residents in the community to have influence on the type and amount of services available to them. In much the same way, giving mental health clients some control and responsibility over their own treatment processes has been shown to be effective. It is the author's opinion that the issues that have been raised the past 10 years in regard to mental health service delivery to minorities is still relevant. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - volunteer citizen participation
KW  - mental health services
KW  - minority groups
KW  - community mental health centers
KW  - service delivery
KW  - 1985
KW  - Community Involvement
KW  - Community Mental Health Centers
KW  - Health Care Delivery
KW  - Mental Health Services
KW  - Minority Groups
KW  - Volunteers
KW  - 1985
DO  - 10.1037/h0085533
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12271-025&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Li, Steven S. -L.
AU  - Tiano, Howard F.
AU  - Fukasawa, Kayoko M.
AU  - Yagi, Kiyohito
AU  - Shimizu, Motoyuki
AU  - Sharief, Farida S.
AU  - Nakashima, Yasutsugu
AU  - Pan, Yu-ching E.
T1  - Protein structure and gene organization of mouse lactate dehydrogenase-A isozyme.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1985/06/03/
VL  - 149
IS  - 2
M3  - Article
SP  - 215
EP  - 225
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The complete covalent structure of the 331 amino acids of mouse lactate dehydrogenase (LDH) A4 isozyme has been determined by sequence analyses of both the protein and the genomic DNA. The mouse LDH-A gene spans a length of at least 7000 bases from the translation initiation codon ATG to the end of the 3′ untranslated region, and it contains six introns that interrupt the pro era-coding sequence. The relationships between the exon-intron organization of LDH-A gene and the structural-functional domains of the protein are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - AMINO acid sequence
KW  - GENES
KW  - LACTATE dehydrogenase
KW  - ISOENZYMES
KW  - EXONS (Genetics)
KW  - INTRONS
KW  - MICE as laboratory animals
N1  - Accession Number: 13841117; Li, Steven S. -L. 1 Tiano, Howard F. 1 Fukasawa, Kayoko M. 1 Yagi, Kiyohito 1 Shimizu, Motoyuki 1 Sharief, Farida S. 1 Nakashima, Yasutsugu 1 Pan, Yu-ching E. 1; Affiliation:  1: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina; Source Info: 6/3/85, Vol. 149 Issue 2, p215; Subject Term: PROTEINS; Subject Term: AMINO acid sequence; Subject Term: GENES; Subject Term: LACTATE dehydrogenase; Subject Term: ISOENZYMES; Subject Term: EXONS (Genetics); Subject Term: INTRONS; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Symmes, D.
AU  - Biben, M.
T1  - Maternal Recognition of Individual Infant Squirrel Monkeys From Isolation Call Playbacks.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1985/07//
VL  - 9
IS  - 1
M3  - Article
SP  - 39
EP  - 46
SN  - 02752565
AB  - Responses of six squirrel monkey (Saimiri sciureus) mothers to playback of a single call type, the ‘isolation peep.’ made by their own infants were tested after mothers and infants had been .separated for more than a week. The playback tapes were edited from tapes containing mixed vocal material recorded when infants and mothers could see but not touch each other. Mothers showed recognition of their own infants compared to other familiar infants by increases in four measures of proximity to the speaker. These data provide evidence that maternal recognition of infants by means of acoustic cues is possible when the test stimuli consist of examples of a single call type with demonstrated individuality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUIRREL monkeys
KW  - BEHAVIOR
KW  - RECOGNITION (Psychology)
KW  - SOUND production by animals
KW  - PARENTAL behavior in animals
KW  - RECALL (Information retrieval)
KW  - ANIMAL behavior
KW  - ANIMAL communication
KW  - HEARING
KW  - ANIMAL psychology
KW  - PRIMATES
N1  - Accession Number: 12274865; Symmes, D. 1 Biben, M. 1; Affiliation:  1: National Institute of Child Health and Human Development in Bethesda, Maryland; Source Info: 1985, Vol. 9 Issue 1, p39; Subject Term: SQUIRREL monkeys; Subject Term: BEHAVIOR; Subject Term: RECOGNITION (Psychology); Subject Term: SOUND production by animals; Subject Term: PARENTAL behavior in animals; Subject Term: RECALL (Information retrieval); Subject Term: ANIMAL behavior; Subject Term: ANIMAL communication; Subject Term: HEARING; Subject Term: ANIMAL psychology; Subject Term: PRIMATES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goldman, Howard H.
AU  - Morrissey, Joseph P.
T1  - The Alchemy of Mental Health Policy: Homelessness and the Fourth Cycle of Reform.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/07//
VL  - 75
IS  - 7
M3  - Article
SP  - 727
EP  - 731
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents a paper that explores the fourth cycle of reform emerging in the past decade in response to the failures of community mental health and deinstitutionalization in the U.S. The new reform is urging to create community support systems, a broad network of mental health and social welfare services for care of the chronically mentally ill in noninstitutional settings. This reform movement is different because it directly addresses the needs of the chronically mentally ill rather than promising to prevent chronicity through the early treatment of acute cases and because it recognizes the problem of the chronically mentally ill as a public health and social welfare problem.
KW  - MENTAL health policy
KW  - HEALTH care reform
KW  - PUBLIC health
KW  - MENTAL health
KW  - MENTAL illness
KW  - PEOPLE with mental disabilities
KW  - PUBLIC welfare
KW  - DISEASES
KW  - UNITED States
N1  - Accession Number: 4949195; Goldman, Howard H. 1 Morrissey, Joseph P. 2; Affiliation:  1: Assistant Director, National Institute of Mental Health, Mental Health Financing, 5600 Fishers Lane, Rockville, MD 20852.  2: Senior Research Sociologist, Office of Mental Health, New York State, Albany, NY.; Source Info: Jul1985, Vol. 75 Issue 7, p727; Subject Term: MENTAL health policy; Subject Term: HEALTH care reform; Subject Term: PUBLIC health; Subject Term: MENTAL health; Subject Term: MENTAL illness; Subject Term: PEOPLE with mental disabilities; Subject Term: PUBLIC welfare; Subject Term: DISEASES; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mackay, I. R.
AU  - Frazer, I. H.
AU  - Toh, B.-H.
AU  - Pedersen, J. S.
AU  - Alter, H. J.
T1  - Absence of autoimmune serological reaction in chronic non A, non B viral hepatitis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1985/07//
VL  - 61
IS  - 1
M3  - Article
SP  - 39
EP  - 43
PB  - Wiley-Blackwell
SN  - 00099104
AB  - In 18 cases of chronic liver disease due to non-A, non-B hepatitis virus(es) in which the diagnosis was established by transmission, including chimpanzee inoculation in nine, sera were tested for the autoantibodies characteristically associated with autoimmune chronic active hepatitis. The frequency of autoantibodies to nuclear, smooth muscle, cytofilament, mitochondrial and liver membrane antigens was low, being not greater than that recorded for a normal population, and the few positive reactions obtained were at very low titre. These findings suggest that among cases of "HBsAg negative" chronic hepatitis, those due to NANB infection are distinguishable from those due to autoimmune chronic hepatitis by negative serological tests for autoantibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOIMMUNE diseases
KW  - HEPATITIS viruses
KW  - AUTOANTIBODIES
KW  - INJECTIONS
KW  - IMMUNOGLOBULINS
KW  - IMMUNOLOGIC diseases
KW  - LIVER
KW  - autoantibodies
KW  - liver antigens
KW  - non A
KW  - non B hepatitis
KW  - post-transfusion hepatitis
N1  - Accession Number: 16182885; Mackay, I. R. 1 Frazer, I. H. 1 Toh, B.-H. 2 Pedersen, J. S. 2 Alter, H. J. 3; Affiliation:  1: Clinical Research Unit of Walter and Eliza Hall Institute of Medical Research and Royal Melbourne Hospital, Melbourne.  2: Department of Pathology and Immunology, Monash University Medical School, Victoria, Australia.  3: Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jul1985, Vol. 61 Issue 1, p39; Subject Term: AUTOIMMUNE diseases; Subject Term: HEPATITIS viruses; Subject Term: AUTOANTIBODIES; Subject Term: INJECTIONS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGIC diseases; Subject Term: LIVER; Author-Supplied Keyword: autoantibodies; Author-Supplied Keyword: liver antigens; Author-Supplied Keyword: non A; Author-Supplied Keyword: non B hepatitis; Author-Supplied Keyword: post-transfusion hepatitis; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tsokos, G. C.
AU  - Inghirami, G.
AU  - Tsoukas, C. D.
AU  - Balow, J. E.
AU  - Lambris, J. D.
T1  - Regulation of immunoglobulin secretion by Factor H of human complement.
JO  - Immunology
JF  - Immunology
Y1  - 1985/07//
VL  - 55
IS  - 3
M3  - Article
SP  - 419
EP  - 426
PB  - Wiley-Blackwell
SN  - 00192805
AB  - As human B lymphocytes and macro-phages carry surface receptors for Factor H (Bi H), we investigated the possibility that this complement component regulates their function. Factor H inhibits immunoglobulin secretion by peripheral mononuclear cells (MNC) stimulated with pokeweed mitogen if present at the initiation of the cultures and at concentrations greater than 50 μg/mI. Factor H also inhibited stimulation and differentiation of purified B cells into immunoglobulin-secreting cells by Epstein-Barr virus (EBV). The inhibitory effect of Factor H was abrogated if anti-Factor H antibody was present in the cultures. EBV-transformed B-cell lines secreted less immunoglobulin if Factor H was present in the culture for at least 4 days. Culture of MNC with Factor H did not lead to the generation of suppressor I cells or macrophages. In contrast, Factor H did not cause proliferation of human peripheral total MNC or enriched I-cell or B-cell subpopulations. Also, Factor H did not inhibit the proliferation of MNC in response to several mitogens and antigens. Our results strongly indicate that Factor H is able to block human B-cell differentiation in vitro without blocking the proliferative ability of the cells. Factor H seems to act directly on the B cells through its receptor on their surface, since it inhibited T-dependent and T-independent B-cell differentiation but generated no suppressor cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - B cells
KW  - MACROPHAGES
KW  - MONONUCLEOSIS
KW  - EPSTEIN-Barr virus
KW  - SUPPRESSOR cells
KW  - MITOGENS
KW  - POKEWEED mitogens
KW  - LYMPHOCYTES
N1  - Accession Number: 14002282; Tsokos, G. C. 1 Inghirami, G. 1 Tsoukas, C. D. 2 Balow, J. E. 1 Lambris, J. D. 3; Affiliation:  1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.  2: Department of Clinical Research, Scripps Clink and Research Foundation, La Jolla, California, U.S.A.  3: Department of Immunology, Scripps Clink and Research Foundation, La Jolla, California, U.S.A.; Source Info: Jul85, Vol. 55 Issue 3, p419; Subject Term: B cells; Subject Term: MACROPHAGES; Subject Term: MONONUCLEOSIS; Subject Term: EPSTEIN-Barr virus; Subject Term: SUPPRESSOR cells; Subject Term: MITOGENS; Subject Term: POKEWEED mitogens; Subject Term: LYMPHOCYTES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1986-14888-001
AN  - 1986-14888-001
AU  - Optican, Lance M.
AU  - Zee, David S.
AU  - Chu, Fred C.
T1  - Adaptive response to ocular muscle weakness in human pursuit and saccadic eye movements.
JF  - Journal of Neurophysiology
JO  - Journal of Neurophysiology
JA  - J Neurophysiol
Y1  - 1985/07//
VL  - 54
IS  - 1
SP  - 110
EP  - 122
CY  - US
PB  - American Physiological Society
SN  - 0022-3077
SN  - 1522-1598
N1  - Accession Number: 1986-14888-001. PMID: 4031979 Partial author list: First Author & Affiliation: Optican, Lance M.; NIH, National Eye Institute Lab of Sensorimotor Research, Bethesda, MD. Release Date: 19860601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Eye Movements; Vision Disorders. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: Jul, 1985. 
AB  - Findings from the present study with 4 patients (aged 42–64 yrs) with ocular muscle weakness indicate that movements of the weak eye were smaller and slower than those made by the normal eye. Saccadic adaptation consisted of a change in the relationship between saccadic amplitude and retinal error to compensate for hypometria, and pursuit adaptation consisted of an increase in the relationship between eye acceleration and the rate of motion of the image of the target on the retina during the initial phase of tracking and an increase in the velocity of tracking of a target moving at a constant velocity. (21 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - saccadic eye movements
KW  - 42–64 yr old patients with ocular muscle weakness
KW  - 1985
KW  - Eye Movements
KW  - Vision Disorders
KW  - 1985
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - KASLOW, RICHARD A.
T1  - AIDS Repository.
JO  - Science
JF  - Science
Y1  - 1985/07/05/
VL  - 229
IS  - 4708
M3  - Article
SP  - 8
EP  - 8
SN  - 00368075
N1  - Accession Number: 87461134; KASLOW, RICHARD A. 1; Affiliation:  1: Epidemiology and Biometry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 7/5/1985, Vol. 229 Issue 4708, p8; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ARYA, SURESH K.
AU  - CHAN GUO
AU  - JOSEPHS, STEVEN F.
AU  - WONG-STAAL, FLOSSIE
T1  - Trans-Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III).
JO  - Science
JF  - Science
Y1  - 1985/07/05/
VL  - 229
IS  - 4708
M3  - Article
SP  - 69
EP  - 73
SN  - 00368075
AB  - Human T-lymphotropic virus type III (HTLV-III) encodes a trans-acting factor that activates the expression of genes linked to the HTLV-III long terminal repeat. By functional mapping of complementary DNA transcripts of viral messenger RNA's the major functional domain of the gene encoding this factor was localized to a region immediately before the env gene of the virus, a region previously thought to be noncoding. This newly identified gene consists of three exons, and its transcription into messenger RNA involves two splicing events bringing together sequences from the 5' part (287 base pairs), middle (268 base pairs), and 3' part (1258 base pairs) of the HTLV-III genome. A similar messenger RNA with a truncated second exon (70 base pairs) does not encode a trans-acting function. It is proposed that this second messenger RNA is the transcript of a gene (3'-orf) located after the env gene. Messenger RNA's were also identified for the env and gag-pol genes of HTLV-III. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461138; ARYA, SURESH K. 1 CHAN GUO 1 JOSEPHS, STEVEN F. 1 WONG-STAAL, FLOSSIE 1; Affiliation:  1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; Source Info: 7/5/1985, Vol. 229 Issue 4708, p69; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SODROSKI, JOSEPH
AU  - PATARCA, ROBERTO
AU  - ROSEN, CRAIG
AU  - WONG-STAAL, FLOSSIE
AU  - HASELTINE, WILLIAM
T1  - Location of the Trans-Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III.
JO  - Science
JF  - Science
Y1  - 1985/07/05/
VL  - 229
IS  - 4708
M3  - Article
SP  - 74
EP  - 77
SN  - 00368075
AB  - The retrovirus involved in acquired immune deficiency syndrome (HTLV-III/LAV) contains a region that is necessary for stimulation of gene expression directed by the viral long terminal repeat. This region is located between nucleotides 5365 and 5607, immediately 5' to the envelope gene. A doubly-spliced message containing this region could encode an 86-amino acid protein with structural features similar to those of nucleic acid-binding proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461166; SODROSKI, JOSEPH 1,2 PATARCA, ROBERTO 1,2 ROSEN, CRAIG 1,2 WONG-STAAL, FLOSSIE 3 HASELTINE, WILLIAM 4; Affiliation:  1: Laboratory of Biochemical Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115  2: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115  3: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205  4: Laboratory of Biochemical Pharmacology, Harvard Medical School; Source Info: 7/5/1985, Vol. 229 Issue 4708, p74; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Podskalny, Judith M.
AU  - Takeda, Shigemasa
AU  - Silverman, Robert E.
AU  - Tran, Dien
AU  - Carpentier, Jean-Louis
AU  - Orci, Lelio
AU  - Gorden, Phillip
T1  - Insulin receptors and bioresponses in a human liver cell line (Hep G-2).
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1985/07/15/
VL  - 150
IS  - 2
M3  - Article
SP  - 401
EP  - 407
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A newly developed human hepatoma cell line, designated Hep G-2, expresses high-affinity insulin receptors meeting all the expected criteria for classic insulin receptors. 125I-insulin binding is time-dependent and temperature-dependent and unlabeled insulin competes for the labeled hormone with a half-maximal displacement of 1–3 ng/ml. This indicates a Kd of about 10-10 M. Since Scatchard analysis of the binding data results in a curvilinear plot and unlabeled insulin accelerates the dissociation of bound hormone, these receptors exhibit the negative cooperative interactions characteristic of insulin receptors in many other cell and tissue types. Proinsulin and des(Ala, Asp)-insulin compete for 125I-insulin binding with 4% and 2%, respectively, of the potency of insulin. Anti-(insulin receptor) antibody competes fully for insulin binding. The two insulin-like growth factors, multiplication-stimulating activity and IGF-I are 2% as potent as insulin against the Hep G-2 insulin receptor. Furthermore, Hep G-2 cells respond to insulin in several bioassays. Glucose uptake, glycogen synthase, uridine incorporation into RNA and acetate incorporation into lipid are all stimulated to varying degrees by physiological concentrations of insulin. In addition, these cells ‘down-regulate’ their insulin receptor, internalize 125I-insulin and degrade insulin in a manner similar to freshly isolated rodent hepatocytes. This is the first available human liver cell line in permanent culture in which both insulin receptors and biological responses have been carefully examined. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INSULIN receptors
KW  - LIVER
KW  - CELL lines
KW  - BINDING sites (Biochemistry)
KW  - ACETATES
KW  - HORMONES
N1  - Accession Number: 13872437; Podskalny, Judith M. 1 Takeda, Shigemasa 2 Silverman, Robert E. 1 Tran, Dien 3 Carpentier, Jean-Louis 3 Orci, Lelio 3 Gorden, Phillip 1; Affiliation:  1: Diabetes Branch, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland  2: Toho University School of Medicine, First Department of Internal Medicine, Tokyo  3: Institute of Histology and Embryology, University of Geneva School of Medicine; Source Info: 7/15/85, Vol. 150 Issue 2, p401; Subject Term: INSULIN receptors; Subject Term: LIVER; Subject Term: CELL lines; Subject Term: BINDING sites (Biochemistry); Subject Term: ACETATES; Subject Term: HORMONES; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Katz, Stephen I.
AU  - Cooper, Kevin D.
AU  - Iijima, Masafumi
AU  - Tsuchida, Tetsuo
T1  - The Role of Langerhans Cells in Antigen Presentation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/07/15/Jul85 Supplement
VL  - 85
M3  - Article
SP  - 96
EP  - 98
SN  - 0022202X
AB  - Epidermal Langerhans cells are dendritic bone marrow-derived cells which synthesize and express Ia antigens. During the past decade, in vitro studies have demonstrated that they play a critical role in the induction of many types of T-cell responses. Specifically, Langerhans cells are effective antigen-presenting cells in allogeneic and antigen specific proliferative and cytotoxic T-cell responses. This paper reviews these functions and suggests areas of future investigations into the mechanisms involved in T-cell activation by Langerhans cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - ANTIGENS
KW  - BONE marrow
KW  - DENDRITIC cells
KW  - T cells
KW  - GRAFT versus host disease
N1  - Accession Number: 12275562; Katz, Stephen I. 1 Cooper, Kevin D. 1 Iijima, Masafumi 1 Tsuchida, Tetsuo 1; Affiliation:  1: Dermatology and Immunology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jul85 Supplement, Vol. 85, p96; Subject Term: LANGERHANS cells; Subject Term: ANTIGENS; Subject Term: BONE marrow; Subject Term: DENDRITIC cells; Subject Term: T cells; Subject Term: GRAFT versus host disease; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12275562
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lawley, Thomas J.
AU  - Bielory, Leonard
AU  - Gascon, Pedro
AU  - Yancey, Kim B.
AU  - Young, Neal S.
AU  - Frank, Michael M.
T1  - A Study of Human Serum Sickness.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/07/15/Jul85 Supplement
VL  - 85
M3  - Article
SP  - 129
EP  - 132
SN  - 0022202X
AB  - Twelve patients with bone marrow failure, who were undergoing therapy with daily intravenous infusions of horse antithymocyte globulin, were studied for the development of serum sickness. Eleven of 12 patients developed typical signs and symptoms of serum sickness 8-13 days after the initiation of treatment. These included fever, malaise, cutaneous eruptions, arthralgias, gastrointestinal disturbances, and lymphadenopathy. Eleven of 12 patients developed high levels of circulating immune complexes during serum sickness. All 12 patients also had concomitant decreases of serum C3 and C4 levels. In addition to urticarial and/or morbilliform eruptions, 8 of 11 patients also developed a serpiginous band of erythema along the sides of the fingers, hands, toes, or feet as an early cutaneous sign of serum sickness. Direct immunofluorescence of lesional skin biopsies during serum sickness revealed deposits of immunoglobulin or complement in the walls of small cutaneous blood vessels in 3 of 5 patients. These findings indicate that circulating immune complexes play a central role in the pathophysiology of human serum sickness. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SERUM sickness
KW  - HUMAN beings
KW  - INTRAVENOUS therapy
KW  - SKIN -- Biopsy
KW  - IMMUNE system
KW  - IMMUNOFLUORESCENCE
N1  - Accession Number: 12275641; Lawley, Thomas J. 1 Bielory, Leonard 2 Gascon, Pedro 2 Yancey, Kim B. 1 Young, Neal S. 2 Frank, Michael M. 3; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Clinical Hematology Branch, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul85 Supplement, Vol. 85, p129; Subject Term: SERUM sickness; Subject Term: HUMAN beings; Subject Term: INTRAVENOUS therapy; Subject Term: SKIN -- Biopsy; Subject Term: IMMUNE system; Subject Term: IMMUNOFLUORESCENCE; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12275641
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pollitt, Ernesto
AU  - Read, Merrill S.
T1  - Bridges between nutrition, neuroscience, and behavior.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1985/08//
VL  - 42
IS  - 2
M3  - Article
SP  - 348
EP  - 351
SN  - 00029165
N1  - Accession Number: 95661723; Pollitt, Ernesto 1; Read, Merrill S. 2; Affiliations: 1: School of Public Health, The University of Texas, Houston, TX; 2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Issue Info: Aug1985, Vol. 42 Issue 2, p348; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Walrath, Judy
AU  - Li, Frederick P.
AU  - Hoar, Shelia K.
AU  - Mead, Marshall W.
AU  - Fraumeni Jr., Joseph F.
T1  - Causes of Death among Female Chemists.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/08//
VL  - 75
IS  - 8
M3  - Article
SP  - 883
EP  - 885
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: A mortality odds ratio analysis of cause of death among 347 White female members of the American Chemical Society (ACS) revealed a five-fold excess of suicide, notably by cyanide poisoning. Risk was also elevated for all cancers combined and for cancers of the breast, ovary, stomach, pancreas, and lymphatic and hematopoietic system. The excess breast and ovary cancer deaths were limited to unmarried women. (Am J Public Health 1985; 75:883-854.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEATH -- Causes
KW  - CANCER in women
KW  - BREAST cancer
KW  - SUICIDE
KW  - POISONING
KW  - CYANIDES
KW  - RATIO analysis
KW  - UNITED States
KW  - AMERICAN Chemical Society
N1  - Accession Number: 4949516; Walrath, Judy 1 Li, Frederick P. 1 Hoar, Shelia K. 1 Mead, Marshall W. 1,2 Fraumeni Jr., Joseph F. 1,3; Affiliation:  1: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Landow 4C03, Bethesda, MD 20205  2: American Chemical Society  3: Epidemiology Section, Medical Division, E. I. DuPont de Nemours Company, Wilmington, DE; Source Info: Aug1985, Vol. 75 Issue 8, p883; Subject Term: DEATH -- Causes; Subject Term: CANCER in women; Subject Term: BREAST cancer; Subject Term: SUICIDE; Subject Term: POISONING; Subject Term: CYANIDES; Subject Term: RATIO analysis; Subject Term: UNITED States; Company/Entity: AMERICAN Chemical Society; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schoenbach, Carrie
T1  - Effects of Husband's and Wife's Social Status on Psychological Functioning.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1985/08//
VL  - 47
IS  - 3
M3  - Article
SP  - 597
SN  - 00222445
AB  - This study explores the importance of each spouse's social stratification position for the other's psychological functioning, challenging long-held assumptions that husband's social-stratification position represents the stratification position of all family members. Using a national sample of 249 employed couples, effects of own and spouse's education, occupational status, and income are assessed on three dimensions of psychological functioning: ideational flexibility, self-directedness of orientation, and distress. The method of analysis involves linear structural equation models. Own stratification position is consistently more important than spouse's. Nonetheless, husband's social-stratification position does have a significant effect on wife`s ideational flexibility. Analysis of the reciprocal relationships between husband's and wife's self-directedness of orientation shows that husband's self-directedness has a much stronger effect on wife `s self-directedness than her self-directedness has on his, suggesting that the process by which stratification position of husband affects wife`s self-directedness is indirect: his social-stratification position affects his personality, and his personality in turn affects his wife's personality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HUSBAND & wife
KW  - SOCIAL status
KW  - DOMESTIC relations
KW  - SOCIAL classes
KW  - SOCIAL stratification
KW  - FAMILY relations
N1  - Accession Number: 5271100; Schoenbach, Carrie 1; Affiliation:  1: National Institute of Mental Health; Source Info: Aug85, Vol. 47 Issue 3, p597; Subject Term: HUSBAND & wife; Subject Term: SOCIAL status; Subject Term: DOMESTIC relations; Subject Term: SOCIAL classes; Subject Term: SOCIAL stratification; Subject Term: FAMILY relations; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06427-051
AN  - 2006-06427-051
AU  - Cullen, Joseph W.
T1  - Frustrations of the Oncologist.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1985/08//
VL  - 30
IS  - 8
SP  - 656
EP  - 656
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06427-051. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Cullen, Joseph W.; Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Death and Dying; Neoplasms; Radiation Therapy. Minor Descriptor: Death Education. Classification: Cancer (3293); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Torpie, Richard J. (Ed); Liegner, Leonard M. (Ed); Chang, Chu H. (Ed); Kutscher, Austin H. (Ed); Mossman, Kenneth L. (Ed); Luk, Kenneth (Ed). Radiation Therapy and Thanatology=Springfield, IL: Charles C. Thomas, 1984. 192 pp. $21.75; 1984. Page Count: 1. Issue Publication Date: Aug, 1985. 
AB  - Reviews the book, Radiation Therapy and Thanatology edited by Richard J. Torpie, Leonard M. Liegner, Chu H. Chang, Austin H. Kutscher, Kenneth L. Mossman, and Kenneth Luk (1984). This edited book is unlike other 'psychosocial' books on cancer in that the background and experience of the authors are relatively homogeneous. In most of the edited psychosocial books, the individual authors vary widely in perspective because the subject matter is so multifaceted. This book is like the others, however, in that very little data are presented to support the contentions made. Nevertheless, the book tells us something extremely important: that we know very little about the people who treat cancer patients and the difficulties that cancer patients have while in treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cancer patients
KW  - radiation therapy
KW  - thanatology
KW  - 1985
KW  - Death and Dying
KW  - Neoplasms
KW  - Radiation Therapy
KW  - Death Education
KW  - 1985
U2  - Torpie, Richard J. (Ed); Liegner, Leonard M. (Ed); Chang, Chu H. (Ed); Kutscher, Austin H. (Ed); Mossman, Kenneth L. (Ed); Luk, Kenneth (Ed). (1984); Radiation Therapy and Thanatology; Springfield, IL: Charles C. Thomas, 1984. 192 pp. $21.75
DO  - 10.1037/024019
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Vita, Claudio
AU  - Fontana, Angelo
AU  - Chaiken, Irwin M.
T1  - Folding of thermolysin fragments.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1985/08/15/
VL  - 151
IS  - 1
M3  - Article
SP  - 191
EP  - 196
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Circular dichroism (CD) and immunochemical measurements have been used to examine conformational properties of COOH-terminal fragments [21 - 316, 206 - 316 and 225 (226) - 316 of thermolysin, and to compare these properties to those of negative thermolysin and thermolysin S, the stable partially active two-fragment complex composed of fragments 5 - 224(225) and 225(226) - 316. In aqueous solution at neutral pH, all the COOH-terminal fragments attain a native-like conformation, as judged both by one content of secondary structure deduced from far-ultraviolet CD spectra and by the recognition of rabbit polyclonal antibodies specific for the COOH-terminal region in native thermolysin. The three fragments showed reversible cooperative unfolding transitions mediated by both heat ad guanidine hydrochloride (Gdn · HCl). The phase transition curves were analyzed for Tm (temperature of half-denaturation) an Gibbs free energies (ΔGD) unfolding from native to denatured state. The observed order of thermal stability is 225(226) - 316 ≤ 206 - 316 < 121 - 316 < thermolysin S < thermolysin. The ranking of ΔGD values for the three fragments correlates with the size of each fragment. Competitive binding studies by radioimmunoassay using 14C-labelled thermolysin and affinity purified antibodies specific for native antigenic determinants in segment 206 - 316 of native thermolysin indicate that the COOH-terminal fragments adopt native-like conformations which are in equilibrium with non-native conformations. These equilibria are shifted towards the native state as the fragment size increases from 225(226) - 316, to 206 - 316, to 121 - 316. Fragment 225(226) - 316, when combined with fragment 5 - 224(225) in the thermolysin S complex, adopts a more stable native-like conformation and becomes much more antigenic. It has been shown that the degree of antigenicity of COOH-terminal fragments towards thermolysin antibodies correlates directly with their conformational stability. The results of this study are discussed is relation to the recently proposed correlation betwen antigenicity and segmental mobility of globular proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - DICHROISM
KW  - IMMUNOCHEMISTRY
KW  - BIOCHEMISTRY
N1  - Accession Number: 13929601; Vita, Claudio 1 Fontana, Angelo 1 Chaiken, Irwin M. 2; Affiliation:  1: Institute of Organic Chemistry, Biopolymer Research Centre of Consiglio Nazionale delle Ricerche, University of Padua  2: Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Maryland; Source Info: 8/15/85, Vol. 151 Issue 1, p191; Subject Term: IMMUNOGLOBULINS; Subject Term: DICHROISM; Subject Term: IMMUNOCHEMISTRY; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Calvieri, Stefano
AU  - Fattorossi, Andera
T1  - Cimetidine for Kaposi's sarcoma.
JO  - Clinical & Experimental Dermatology
JF  - Clinical & Experimental Dermatology
Y1  - 1985/09//
VL  - 10
IS  - 5
M3  - Letter
SP  - 499
EP  - 500
SN  - 03076938
AB  - Presents a letter to the editor related to the treatment of Kaposi's sarcoma, published in the September 1985 issue of the journal "Clinical and Experimental Dermatology."
KW  - LETTERS to the editor
KW  - KAPOSI'S sarcoma
KW  - TREATMENT
N1  - Accession Number: 11690561; Calvieri, Stefano 1 Fattorossi, Andera 1; Affiliation:  1: Laboratory of Tumor Immunology and Biology, Building 10, Room 8BO8, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, U. S. A..; Source Info: Sep85, Vol. 10 Issue 5, p499; Subject Term: LETTERS to the editor; Subject Term: KAPOSI'S sarcoma; Subject Term: TREATMENT; Number of Pages: 2p; Document Type: Letter
L3  - 10.1111/1365-2230.ep11690561
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dennis, Barbara
AU  - Shifflett, Peggy A.
T1  - A conceptual and methodological model for studying dietary habits in the community.
JO  - Ecology of Food & Nutrition
JF  - Ecology of Food & Nutrition
Y1  - 1985/09//
VL  - 17
IS  - 3
M3  - Article
SP  - 253
EP  - 262
SN  - 03670244
AB  - This paper presents a conceptual and methodological model to study dietary habits in the community. This effort is in response to the need to develop multi‐dimensional concepts of dietary behavior in free‐living populations and innovative methods appropriate for their study. A theoretical construct, dietary habit, is presented. After describing current methods used in both social and nutrition research, a model is suggested for integrating them in epidemiological research design to study dietary habit. This model is adapted from the sociological technique of triangulation. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Ecology of Food & Nutrition is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75863365; Dennis, Barbara 1; Shifflett, Peggy A. 2; Affiliations: 1: National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Maryland; 2: Department of Sociology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Issue Info: Sep1985, Vol. 17 Issue 3, p253; Number of Pages: 10p; Document Type: Article
L3  - 10.1080/03670244.1985.9990900
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ER  - 

TY  - RPRT
AU  - Ansel, John C.
AU  - Mountz, John
AU  - Steinberg, Alfred D.
AU  - DeFabo, Edward
AU  - Green, Ira
T1  - Effects of UV Radiation on Autoimmune Strains of Mice: Increased Mortality and Accelerated Autoimmunity in BXSB Male Mice.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/09//
VL  - 85
IS  - 3
M3  - Report
SP  - 181
EP  - 186
SN  - 0022202X
AB  - Systemic lupus erythematosus is an immunologically mediated autoimmune disease which has been reported to be aggravated by certain environmental agents such as ultraviolet irradiation (UV). To further investigate this interaction, we examined the consequences of UV exposure on the autoimmune process of several strains of autoimmune mice. Strains of age- and sex-matched, 3- to 4-month old, autoimmune (MRL-lpr/lpr, (NZB× NZW)F1, BXSB) and nonautoimmune (BALB/c, B10.A) mice were shaved and exposed to an acute (2 h daily × 7 days) and a chronic (3 h/weekly × 4 weeks) dose of UV (FS40 lamps, 2 mJ/cm2/s). UV-induced changes in survival, autoantibody production, splenic B-cell activity, and target organ pathology were examined. After an acute UV exposure there were (10/15) deaths in the UV BXSB males and 4/15 in the UV BXSB females, compared to 1/15 in the non-UV BXSB male group and (0/15 in the non-UV BXSB females. No deaths occurred in the other UV autoimmune or nonautoimmune groups. Likewise, chronic UV resulted in increased UV BXSB male mortality 13/15 compared to UV BXSB females 2/15 and non-UV BXSB males and females. No deaths occurred in the other autoimmune (MRL-lpr/lpr, (NZB×NZW)F1) or nonautoimmune (BALB/c, B10.A) strains, after chronic UV exposure. Equivalent doses of Mylar-filtered FS40 UV (UVB deleted) resulted in no deaths in the UV BXSB male group. Acute and chronic UV also resulted in a significant increase in serum single-stranded DNA antibody production, splenic poly-clonal B-cell activity, and renal glomerular inflammatory changes in the UV BXSB male mice. Thus, UV resulted in premature death and accelerated autoimmunity in UV BXSB males and may serve as a useful model for phototoxicity in autoimmunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOIMMUNE diseases
KW  - MICE
KW  - AUTOIMMUNITY
KW  - SYSTEMIC lupus erythematosus
KW  - ULTRAVIOLET radiation
KW  - AUTOANTIBODIES
N1  - Accession Number: 12276652; Ansel, John C. 1 Mountz, John 2 Steinberg, Alfred D. 2 DeFabo, Edward 3 Green, Ira 1; Affiliation:  1: Laboratory of Immunology, George Washington School of Medicine, Washington, D.C., U.S.A.  2: National Institute of Allergy and Infectious Diseases, and Cellular Immunology Section, Arthritis and Rheumatism Branch, George Washington School of Medicine, Washington, D.C., U.S.A.  3: National Institute of Arthritis, Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, and Department of Dermatology. George Washington School of Medicine, Washington, D.C., U.S.A.; Source Info: Sep85, Vol. 85 Issue 3, p181; Subject Term: AUTOIMMUNE diseases; Subject Term: MICE; Subject Term: AUTOIMMUNITY; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: ULTRAVIOLET radiation; Subject Term: AUTOANTIBODIES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Report
L3  - 10.1111/1523-1747.ep12276652
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Piegorsch, Walter W.
T1  - Average-Width Optimality for Confidence Bands in Simple Linear Regression.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/09//
VL  - 80
IS  - 391
M3  - Article
SP  - 692
SN  - 01621459
AB  - The problem of constructing optimal confidence bands for a simple linear regression over the whole real line is considered. Optimality is defined as minimization of the average width of the bands weighted by a normalized function. This weight function is presented as an indicator of experimental interest in the varying width of the band. A comparison between the commonly seen hyperbolic bands and segmented-line bands is presented. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - REGRESSION analysis
KW  - SAMPLING (Statistics)
KW  - STATISTICAL hypothesis testing
KW  - MATHEMATICAL statistics
KW  - CONFIDENCE intervals
KW  - EXPONENTIAL functions
KW  - Constrained minimization.
KW  - Prior weight functions
KW  - Simultaneous confidence intervals
N1  - Accession Number: 4608242; Piegorsch, Walter W. 1; Affiliations: 1: Mathematical Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Sep85, Vol. 80 Issue 391, p692; Thesaurus Term: REGRESSION analysis; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MATHEMATICAL statistics; Subject Term: CONFIDENCE intervals; Subject Term: EXPONENTIAL functions; Author-Supplied Keyword: Constrained minimization.; Author-Supplied Keyword: Prior weight functions; Author-Supplied Keyword: Simultaneous confidence intervals; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Parke, Robert
T1  - Statistical Abstract of the United States (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/09//
VL  - 80
IS  - 391
M3  - Book Review
SP  - 771
SN  - 01621459
AB  - Reviews the book "Statistical Abstract of the United States: 1984," 104th ed.
KW  - STATISTICS
KW  - NONFICTION
KW  - 1984: The National Data Book (Book)
N1  - Accession Number: 4608704; Parke, Robert 1; Affiliations: 1: National Cancer Institute.; Issue Info: Sep85, Vol. 80 Issue 391, p771; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: 1984: The National Data Book (Book); Number of Pages: 3/4p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Berzofsky, Jay A.
T1  - Intrinsic and Extrinsic Factors in Protein Antigenic Structure.
JO  - Science
JF  - Science
Y1  - 1985/09/06/
VL  - 229
IS  - 4717
M3  - Article
SP  - 932
EP  - 940
SN  - 00368075
AB  - Recent advances in the preparation of synthetic peptide vaccines and the use of synthetic peptides as probes of antigenic structure and function have led to renewed interest in the prediction of antigenic sites recognized by antibodies and T cells. This review focuses on antibodies. Features intrinsic to the antigen, such as hydrophilicity and mobility, may be useful in the selection of amino acid sequences of the native protein that will elicit antibodies cross-reacting with peptides, or sequences which, as peptides, will be more likely to elicit antibodies cross-reactive with the native protein. Structural mobility may also contribute to protein-protein interactions in general. However, the entire accessible surface of a protein is likely to be detectable by a large enough panel of antibodies. Which of these antibodies are made in any individual depends on factors extrinsic to the antigen molecule, host factors such as self-tolerance, immune response genes, idiotype networks, and the immunoglobulin structural gene repertoire. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461206; Berzofsky, Jay A. 1; Affiliation:  1: Senior Investigator, Metabolism Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 9/6/1985, Vol. 229 Issue 4717, p932; Number of Pages: 9p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - KING, C. RICHTER
AU  - KRAUS, MATTHIAS H.
AU  - AARONSON, STUART A.
T1  - Amplification of a Novel v-erbB-Related Gene in a Human Mammary Carcinoma.
JO  - Science
JF  - Science
Y1  - 1985/09/06/
VL  - 229
IS  - 4717
M3  - Article
SP  - 974
EP  - 976
SN  - 00368075
AB  - The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to verbB but amplified in a manner that appeared to distinguish itfrom the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461209; KING, C. RICHTER 1 KRAUS, MATTHIAS H. 1 AARONSON, STUART A. 1; Affiliation:  1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Source Info: 9/6/1985, Vol. 229 Issue 4717, p974; Number of Pages: 3p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Vuust, Jens
AU  - Sobel, Mark E.
AU  - Martin, George R.
T1  - Regulation of type I collagen synthesis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1985/09/16/
VL  - 151
IS  - 3
M3  - Article
SP  - 449
EP  - 453
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The type I collagen molecule contains two α1(I) chains and one α2(I) chain. Previous investigations, using embryonic chick calvaria have indicated that the two chains are synthesized in a 2: 1 ratio which is controlled at a pretranslational level, since the cells contain twice as much translatable proα1(I) mRNA as proα2(I) mRNA. The present report describes hybridization analyses of the cellular levels of total cellular RNAs coding for the proα1(1) and proα2(I) chains, using as probes two cloned cDNAs complementary to chick proα1(I) and proα2(I) mRNA, respectively. Total cellular RNA was extracted from embryonic chick calvaria, proα1(I) and proα1(I) RNA sequences were quantified by Northern hybridization using conditions ensuring that hybridization efficiency and specific radioactivity were the same for the two probes. Similar analyses were carried out on RNA extracted from calvaria with different levels of collagen synthesis after culture in the presence or absence of ascorbic acid. The results for all samples analyzed indicate that total cellular proα1(I) and proα2(I) mRNAs are present in a 2:1 ratio which is maintained even during variations in collagen synthesis rate. There is no evidence for regulation mediated by different rates of processing of mRNA precursors, although preferential degradation of the proα2(I) gene transcript cannot be excluded. Thus, the synthesis of type I procollagen chains is presumably coordinated by transcriptional control. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLLAGEN
KW  - EXTRACELLULAR matrix proteins
KW  - MESSENGER RNA
KW  - HYBRIDIZATION
KW  - NUCLEIC acids
KW  - BREEDING
N1  - Accession Number: 15801489; Vuust, Jens 1 Sobel, Mark E. 1 Martin, George R. 1; Affiliation:  1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda. Maryland; Source Info: 9/16/85, Vol. 151 Issue 3, p449; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: MESSENGER RNA; Subject Term: HYBRIDIZATION; Subject Term: NUCLEIC acids; Subject Term: BREEDING; Number of Pages: 5p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Russell-Briefel, Ronette
AU  - Ezzati, Trena
AU  - Perlman, Jeffrey
T1  - Prevalence and Trends in Oral Contraceptive Use in Premenopausal Females Ages 12-54 Years, United States, 1971-80.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/10//
VL  - 75
IS  - 10
M3  - Article
SP  - 1173
EP  - 1176
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Data from the second National Health and Nutrition Examination Survey (NHANES II) were analyzed to estimate the prevalence of oral contraceptive use in the United States. 1976-80. The overall unadjusted prevalence of oral contraceptive use was 16.7 per ¢ for premenopausal females ages 12-54 years (19.2 per ¢ for ages 15-44 years), Approximately 8.7 million females (95 per ¢ confidence interval, 6.9-10.5 million) were oral contraceptive users at the midpoint of NHANES II (March 19781). Comparison to the NHANES I, conducted in 1971-74, indicated a stable number of overall oral contraceptive users in the US population during the 1970s, with shifts in certain age groups: oral contraceptive use increased for females ages 12-19 years and decreased for females ages 20-49 years. The overall age-adjusted prevalences indicated a 2 per ¢ 195 per ¢ CI, 0.2-3.8 per ¢) decline in oral contraceptive use from the early to the Late 1970s, The NHANES provides comparative data and supports findings from another national survey showing a decrease in the per ¢ of females using oral contraceptives during 1973-82. Trends in oral contraceptive use are also presented by race. poverty level, rural-urban residence, marital status, and education level. (Am J Public Health 1985:75:1173-1176.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ORAL contraceptives
KW  - CONTRACEPTIVE drugs
KW  - WOMEN
KW  - RACE
KW  - MARITAL status
KW  - EDUCATION
KW  - SOCIAL status
KW  - CONTRACEPTION
KW  - UNITED States
N1  - Accession Number: 4947756; Russell-Briefel, Ronette 1 Ezzati, Trena 1 Perlman, Jeffrey 2; Affiliation:  1: National Center for health Statistics.  2: National Institute of Child Health and Human Development.; Source Info: Oct85, Vol. 75 Issue 10, p1173; Subject Term: ORAL contraceptives; Subject Term: CONTRACEPTIVE drugs; Subject Term: WOMEN; Subject Term: RACE; Subject Term: MARITAL status; Subject Term: EDUCATION; Subject Term: SOCIAL status; Subject Term: CONTRACEPTION; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tietz, Dietmar
T1  - Characterization of a novel (--+)-abscisic acid metabolite.
JO  - Physiologia Plantarum
JF  - Physiologia Plantarum
Y1  - 1985/10//
VL  - 65
IS  - 2
M3  - Article
SP  - 171
EP  - 176
SN  - 00319317
AB  - By application of (±)-abscisic acid and (±)-[1-14C]-abscisic acid to pea seedlings (<em>Pisum sativum</em> L. cv. Kleine Rheinländerin) a new abscisic acid metabolite (<em>Pisumic</em> acid, PISA) could be isolated and structurally characterized by combined gas chromatography-mass spectrometry. From data of exact mass determination, it is suggested that the metabolite has the tentative structure of 4-dihydroabscisic acid with a hydroxylated methyl: group at C-6'. That this could be evidence for an alternative pathway of abscisic acid metabolism which was suggested earlier by Walton et al. [PIanta 112: 87-90 (1973)] is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEAS
KW  - METABOLITES
KW  - ABSCISIC acid
KW  - MASS spectrometry
KW  - SEEDLINGS
KW  - PLANT metabolism
KW  - 4'-desoxy-abscisic acid
KW  - 4'-dihydro-abscisic acid
KW  - <em>Pisum sativum</em>.
KW  - Abscisic acid metabolism
KW  - mass spectrometry
KW  - Pisumic acid
N1  - Accession Number: 12906263; Tietz, Dietmar 1; Affiliation:  1: Section on Macromolecular Analysis, Lab. of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National institutes of Health, Bethesda, MD 20205, USA.; Source Info: Oct85, Vol. 65 Issue 2, p171; Subject Term: PEAS; Subject Term: METABOLITES; Subject Term: ABSCISIC acid; Subject Term: MASS spectrometry; Subject Term: SEEDLINGS; Subject Term: PLANT metabolism; Author-Supplied Keyword: 4'-desoxy-abscisic acid; Author-Supplied Keyword: 4'-dihydro-abscisic acid; Author-Supplied Keyword: <em>Pisum sativum</em>.; Author-Supplied Keyword: Abscisic acid metabolism; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: Pisumic acid; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 111130 Dry Pea and Bean Farming; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1399-3054.ep12906263
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2014-02372-002
AN  - 2014-02372-002
AU  - Backer, Thomas E.
AU  - Levine, Irene Shifren
T1  - Building bridges: Program and peer consultation to enhance services to the severely mentally ill.
JF  - Psychosocial Rehabilitation Journal
JO  - Psychosocial Rehabilitation Journal
Y1  - 1985/10//
VL  - 9
IS  - 2
SP  - 3
EP  - 13
CY  - US
PB  - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN  - 0147-5622
N1  - Accession Number: 2014-02372-002. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Backer, Thomas E.; Human Interaction Research Institute, Los Angeles, CA, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Organizations; Peers; Professional Consultation; Psychosocial Rehabilitation. Minor Descriptor: Severity (Disorders). Classification: Rehabilitation (3380). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: Oct, 1985. 
AB  - Psychosocial rehabilitation agencies are beginning to identify and use opportunities for consultation, both on a peer level with other agencies and with organizations that have some service responsibility or contact with severely mentally ill people. This article reviews recent changes in services for the chronically mentally ill that have stimulated the need for consultation; provides an overview of peer and program consultation; provides an overview of peer and program consultation on chronic mental illness; and suggests opportunities for psychosocial rehabilitation agency staff to develop consulting opportunities in their own community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychosocial rehabilitation agencies
KW  - severely mentally ill
KW  - program consultation
KW  - peer consultation
KW  - 1985
KW  - Mental Disorders
KW  - Organizations
KW  - Peers
KW  - Professional Consultation
KW  - Psychosocial Rehabilitation
KW  - Severity (Disorders)
KW  - 1985
U1  - Sponsor: National Institute of Mental Health, Office of State and Community Liaison, US. Recipients: No recipient indicated
U1  - Sponsor: Office of Prevention. Recipients: No recipient indicated
DO  - 10.1037/h0099141
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-11626-001
AN  - 2009-11626-001
AU  - Pedersen, Frank A.
T1  - Leon J. Yarrow (1921–1982).
JF  - American Psychologist
JO  - American Psychologist
JA  - Am Psychol
Y1  - 1985/10//
VL  - 40
IS  - 10
SP  - 1137
EP  - 1137
CY  - US
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
N1  - Accession Number: 2009-11626-001. Partial author list: First Author & Affiliation: Pedersen, Frank A.; National Institute of Child Health and Human Development, US. Release Date: 20090810. Correction Date: 20100125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Obituary. Language: English. Major Descriptor: Psychologists. Minor Descriptor: Childhood Development. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Page Count: 1. Issue Publication Date: Oct, 1985. 
AB  - Presents an obituary for Leon J. Yarrow. Yarrow was born on September 30, 1921, in Shenandoah, Pennsylvania. His father died when Leon was very young, and he experienced some of the transitions in attachments and care that may well have influenced his life-long research interest in the importance of early experience for the developing child. At age 15 Leon entered the University of Pennsylvania, where he majored in psychology. In 1951 Leon accepted the first research position that was made available in the old U.S. Children's Bureau. He initiated a longitudinal investigation of adopted children that focused on the consequences of the infant's transition from foster care to the adoptive parents. As his findings became known, social work practice was modified to favor adoption at the earliest ages. Leon spent a major part of his career at the National Institutes of Health (NIH). His associates there were uniformly touched by his personal warmth, his unrelentingly high standards for developmental studies, and the conceptual elegance with which he grasped problems. Leon died July 28, 1982, of a heart attack, the day before he planned to embark on a summer vacation with his family. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Leon Yarrow
KW  - psychologists
KW  - child development
KW  - 1985
KW  - Psychologists
KW  - Childhood Development
KW  - 1985
DO  - 10.1037/h0092156
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ER  - 

TY  - JOUR
ID  - 2015-21770-001
AN  - 2015-21770-001
AU  - Lansky, Lester L.
AU  - List, Marcy A.
AU  - Lansky, Shirley B.
AU  - Cohen, Michael E.
AU  - Sinks, Lucius F.
T1  - Toward the development of a Play Performance Scale for Children (PPSC).
JF  - Cancer
JO  - Cancer
JA  - Cancer
Y1  - 1985/10/01/
VL  - 56
IS  - 7, Suppl
SP  - 1837
EP  - 1840
CY  - US
PB  - John Wiley & Sons
SN  - 0008-543X
SN  - 1097-0142
AD  - Lansky, Lester L., Department of Neurology, University of Illinois College of Medicine, 912 South Wood Street, 855-N, NPI, Chicago, IL, US, 60612
N1  - Accession Number: 2015-21770-001. PMID: 4027922 Partial author list: First Author & Affiliation: Lansky, Lester L.; Department of Neurology, University of Illinois, IL, US. Release Date: 20150525. Correction Date: 20161024. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: American Cancer Society Conference: Pediatric Brain Tumor Workshop, Jun, 1984, Niagara-on-the-Lake, ON, Canada. Conference Note: An earlier version of this article was presented at the aforementioned conference. Major Descriptor: Brain Neoplasms; Childhood Play Development; Developmental Age Groups; Developmental Measures; Test Construction. Minor Descriptor: Childhood Play Behavior; Psychological Assessment; Rating Scales; Test Reliability; Test Validity. Classification: Developmental Scales & Schedules (2222); Cancer (3293). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Play Performance Scale for Children DOI: 10.1037/t05801-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Oct 1, 1985. 
AB  - Performance scales (i.e., Karnofsky), as they measure quality of life, have been used effectively as an integral part of repeated assessment of adult cancer patients for the last several years. An equally concise measure of performance has not been developed for children. The task of developing a scale to assess performance in infants, toddlers, school-age children, and adolescents is formidable, as the activity measured should be of equal merit at each age level. Although all childhood cancer patients could benefit from a simple-to-administer, rapid assessment, children with brain tumors have the greatest need for a repeated measure of performance. The goal then, is to develop a simplified set of criteria that can be used for assessment of children with brain tumors during hospitalization, at the time of clinic visits, and/or at the time of diagnostic procedures when the patient is in a reasonable state of health. The assessment should be able to be performed by nonprofessional persons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - performance scale
KW  - childhood cancer patients
KW  - infants
KW  - toddlers
KW  - school-age children
KW  - adolescents
KW  - brain tumors
KW  - 1985
KW  - Brain Neoplasms
KW  - Childhood Play Development
KW  - Developmental Age Groups
KW  - Developmental Measures
KW  - Test Construction
KW  - Childhood Play Behavior
KW  - Psychological Assessment
KW  - Rating Scales
KW  - Test Reliability
KW  - Test Validity
KW  - 1985
DO  - 10.1002/1097-0142(19851001)56:7+<1837::AID-CNCR2820561324>3.0.CO;2-Z
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DB  - psyh
ER  - 

TY  - JOUR
AU  - Forman, Michele R.
AU  - Fetterly, Karen
AU  - Graubard, Barry I.
AU  - Wooton, Karen G.
T1  - Exclusive breast-feeding of newborns among married women in the United States: the National Natality Surveys of 1969 and 1980.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1985/11//
VL  - 42
IS  - 5
M3  - Article
SP  - 864
EP  - 869
SN  - 00029165
AB  - Questions about infant feeding practices after birth were included in 1969 and 1980 National Natality Surveys (NNS). At 3-6 mo postpartum, NNS questionnaires were mailed to mothers of live infants born in wedlock, and responses were weighted to permit national estimates. Based on the NNS, the proportion of women who were exclusively breast-feeding newborns in the United States was significantly lower in 1969 (19% of white women, 9% of black women) compared with 1980 (51% of white women, 25% of black women). In 1969, the highest percentages of exclusive breast-feeding were observed among white women ≤ 34 yr, of parity ≤ 3 and > 7, and of higher than lower socioeconomic groups; and among black women ≥ 30 yr, of parity ≥ 4, and of lower than higher socioeconomic groups. Among women in both races in 1980, more primiparae than multiparae and the more highly educated were breast-feeding. More white than black women exclusively breastfed within each birthweight and each sociodemographic characteristic in 1980; therefore, the racial differences remained across these factors. These findings are compared with results of the Ross Laboratories surveys of infant feeding. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Breastfeeding (Humans)
KW  - Sociodemographic factors
KW  - Socioeconomic factors
KW  - Married women -- Attitudes
KW  - United States
KW  - birthweight
KW  - bottle-feeding
KW  - Breast-feeding
KW  - sociodemographic
N1  - Accession Number: 90624271; Forman, Michele R. 1; Fetterly, Karen 2; Graubard, Barry I. 2; Wooton, Karen G. 1; Affiliations: 1: Division of Nutrition, Center for Health Promotion and Education, Centers for Disease Control, Atlanta. GA; 2: National Institute for Child Health and Human Development, Bethesda, MD; Issue Info: Nov1985, Vol. 42 Issue 5, p864; Subject Term: Breastfeeding (Humans); Subject Term: Sociodemographic factors; Subject Term: Socioeconomic factors; Subject Term: Married women -- Attitudes; Subject: United States; Author-Supplied Keyword: birthweight; Author-Supplied Keyword: bottle-feeding; Author-Supplied Keyword: Breast-feeding; Author-Supplied Keyword: sociodemographic; Number of Pages: 6p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Simopoulos, Artemis P.
T1  - The nutritional aspects of hypertension.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1985/11//
VL  - 42
IS  - 5
M3  - Article
SP  - 909
EP  - 912
SN  - 00029165
AB  - The article discusses the various papers presented at the Workshop on Nutrition and Hypertension, which was held on March 12-14, 1984. Topics discussed include laboratory methods in nutrition research, nutritional factors involved in the pathogenesis of hypertension, and the role of sodium in hypertension. Researchers David M. Hegsted, John R. Gill, and Richard J. Havlik participated in the workshop.
KW  - Hypertension -- Nutritional aspects
KW  - Hypertension -- Congresses
KW  - Sodium -- Physiological effect
KW  - Nutrition research
KW  - Gill, John R.
N1  - Accession Number: 90624281; Simopoulos, Artemis P. 1; Affiliations: 1: Chairman, Nutrition Coordinating Committee, National Institutes of Health, Building 31, Room 4B59, Bethesda, MD 20892; Issue Info: Nov1985, Vol. 42 Issue 5, p909; Subject Term: Hypertension -- Nutritional aspects; Subject Term: Hypertension -- Congresses; Subject Term: Sodium -- Physiological effect; Subject Term: Nutrition research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: Gill, John R.; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Bergner, Lawrence
AU  - Hallstrom, Alfred P.
AU  - Bergner, Marilyn
AU  - Eisenberg, Mickey S.
AU  - Cobb, Leonard A.
T1  - Health Status of Survivors of Cardiac Arrest and of Myocardial Infarction Controls.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1985/11//
VL  - 75
IS  - 11
M3  - Article
SP  - 1321
EP  - 1323
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We interviewed 308 survivors of out-of-hospital cardiac arrest and matched controls who had suffered a myocardial infarction. The Sickness Impact Profile (SIP) scores of controls were somewhat lower (better) than those of cases, but responses of cases and controls to additional questions about stair climbing, irritability and mood were virtually identical. Half as many (18 per cent) controls as cases (38 per cent) reported poorer memory function; nevertheless, 63 per cent of cases and 79 per cent of controls who had been working outside the home at the time of the event were employed at the time of the interview. (Am J Public Health 1985; 75:1321-1323.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARDIAC arrest
KW  - CARDIAC patients
KW  - MYOCARDIAL infarction
KW  - SICKNESS Impact Profile
KW  - HEALTH status indicators
KW  - MEMORY
N1  - Accession Number: 4947495; Bergner, Lawrence 1 Hallstrom, Alfred P. 2 Bergner, Marilyn 3 Eisenberg, Mickey S. 4 Cobb, Leonard A. 5; Affiliation:  1: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD  2: Research Professor, Department of Biostatistics, University of Washington  3: Professor of Health Services, University of Washington  4: Associate Professor, Department of Medicine, University of Washington, Seattle, WA 98195  5: Professor, Department of Medicine, University of Washington; Source Info: Nov85, Vol. 75 Issue 11, p1321; Subject Term: CARDIAC arrest; Subject Term: CARDIAC patients; Subject Term: MYOCARDIAL infarction; Subject Term: SICKNESS Impact Profile; Subject Term: HEALTH status indicators; Subject Term: MEMORY; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Miller, Joanne
AU  - Slomczynski, Kazimierz M.
AU  - Kohn, Melvin L.
T1  - Continuity of Learning-Generalization: The Effect of Job on Men's Intellective Process in the United States and Poland.
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1985/11//
VL  - 91
IS  - 3
M3  - Article
SP  - 593
EP  - 615
SN  - 00029602
AB  - Job conditions have a direct effect on whether workers will be ideologically flexible or conservative; likewise, workers' intellective processes affect choices of working conditions throughout adult life.
KW  - AUTONOMY (Psychology)
KW  - OCCUPATIONS
KW  - INTELLECT
KW  - REGRESSION analysis
KW  - MULTIPLE regression analysis
KW  - OLDER people -- United States
KW  - EMPLOYEES
KW  - WORK environment
KW  - MEN
KW  - IDEOLOGY
KW  - POLAND
KW  - UNITED States
KW  - EDUCATION, TRAINING, AND CAREER DEVELOPMENT
N1  - Accession Number: 15648903; Miller, Joanne 1; Slomczynski, Kazimierz M. 2; Kohn, Melvin L. 3; Affiliations: 1 : National Institute of Mental Health and Russell Sage Foundation; 2 : National Institute of Mental Health and University of Warsaw; 3 : National Institute of Mental Health and Johns Hopkins University;  Source Info: Nov85, Vol. 91 Issue 3, p593; Historical Period: 1964 to 1978; Subject Term: AUTONOMY (Psychology); Subject Term: OCCUPATIONS; Subject Term: INTELLECT; Subject Term: REGRESSION analysis; Subject Term: MULTIPLE regression analysis; Subject Term: OLDER people -- United States; Subject Term: EMPLOYEES; Subject Term: WORK environment; Subject Term: MEN; Subject Term: IDEOLOGY; Subject: POLAND; Subject: UNITED States; Author-Supplied Keyword: EDUCATION, TRAINING, AND CAREER DEVELOPMENT; Number of Pages: 23p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - NEWS
AU  - Moshell, Alan N.
T1  - Sources of Research Support: Overview and Discussion.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/11//
VL  - 85
IS  - 5
M3  - Editorial
SP  - 391
EP  - 393
SN  - 0022202X
AB  - This article focuses on research support for a survey conducted by "The Society for Investigative Dermatology" on the scope of skin disease. The survey reported revealed that the National Institutes of Health (NIH) provided almost two-thirds of such support. The survey also indicated that approximately three out of every five approved NIH applications were funded. However, the NIH has made an attempt to encourage young scientists into biomedical research careers by modifying existing support mechanisms and developing new support mechanisms in the areas of research training.
KW  - RESEARCH grants
KW  - SURVEYS
KW  - SKIN diseases
KW  - TRAINING
KW  - SCIENTISTS
KW  - SOCIETY for Investigative Dermatology
N1  - Accession Number: 12277049; Moshell, Alan N. 1; Affiliation:  1: National Institutes of Health Bethesda, Maryland.; Source Info: Nov85, Vol. 85 Issue 5, p391; Subject Term: RESEARCH grants; Subject Term: SURVEYS; Subject Term: SKIN diseases; Subject Term: TRAINING; Subject Term: SCIENTISTS; Company/Entity: SOCIETY for Investigative Dermatology; NAICS/Industry Codes: 813219 Other Grantmaking and Giving Services; Number of Pages: 3p; Document Type: Editorial
L3  - 10.1111/1523-1747.ep12277049
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12277049&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tomita, Yasushi
AU  - Montague, Paul M.
AU  - Hearing, Vincent J.
T1  - Anti-T4-Tyrosinase Monoclonal Antibodies-Specific Markers for Pigmented Melanocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/11//
VL  - 85
IS  - 5
M3  - Article
SP  - 426
EP  - 430
SN  - 0022202X
AB  - Tyrosinase (EC 1.14.18.1) is the enzyme essential to pigment formation in mammals; this enzyme is specifically localized in melanocytes, which occur primarily in the skin, hair bulbs, and eyes. Three hybridomas, TMH1, TMH-2, and TMH-3, which produce monoclonal antibodies directed against tyrosinase, were obtained by fusion of SP2/0 myeloma cells and lymphocytes of rats hyperimmunized with purified melanosomal tyrosinase. These three monoclonal antibodies bound specifically to the mature, T4 form of tyrosinase, and did not bind to either of the precursor forms (T1 or T2) of the enzyme, which demonstrates that further posttranslational modifications of this enzyme occur which had not previously been detected. Epitope mapping studies have shown that at least two different immunologic determinants on tyrosinase are recognized by these antibodies. All three antibodies showed positive immunofluorescence staining of pigmented murine melanocytes from various sources, including B16 melanoma growing in vivo and in vitro, epidermal melanocytes, and retinal melanocytes. The antibodies did not cross-react with unpigmented cells, including K1735 amelanotic melanoma cells, albino murine skin or eye tissue, fibrosarcoma cells, rat fibroblasts, or epidermal keratinocytes. These monoclonal antibodies are sensitive, highly specific probes for pigmented mammalian melanocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHENOL oxidase
KW  - ENZYMES
KW  - IMMUNOGLOBULINS
KW  - MELANOCYTES
KW  - LYMPHOCYTES
KW  - MELANOMA
N1  - Accession Number: 12277121; Tomita, Yasushi 1 Montague, Paul M. 2 Hearing, Vincent J. 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov85, Vol. 85 Issue 5, p426; Subject Term: PHENOL oxidase; Subject Term: ENZYMES; Subject Term: IMMUNOGLOBULINS; Subject Term: MELANOCYTES; Subject Term: LYMPHOCYTES; Subject Term: MELANOMA; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277121
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Digiovanna, John J.
AU  - Fletcher, R. Theodore
AU  - Chader, Gerald J.
T1  - Qualitative and Quantitative Analysis of Cytosol Retinoid Binding Proteins in Human Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/11//
VL  - 85
IS  - 5
M3  - Article
SP  - 460
EP  - 464
SN  - 0022202X
AB  - The distribution of the cytosol retinol and retinoic acid binding proteins are known to vary greatly within the different layers of the eye, a retinoid target organ. We have analyzed the cytosol retinoid binding from adult human skin, another retinoid target organ, and examined the relative contribution of the epidermis and dermis to the total retinoid binding. The mean specific activity of [3H]retinol (0.52 ± 0.06 pmol/mg protein) and [3H]retinoic acid (3.20 ± 0.45 pmol/mg protein) binding to cytosol preparations from different specimens of adult human skin was determined. On the ayerage these skins bound 7-fold more retinoic acid than retinol. When skin was treated with EDTA and separated into epidermal and dermal fractions, [3H]retinol and [3H]retinoic acid binding was found in the cytosol derived from epidermis (0.36 ±0.03 pmol/mg protein, 3.69 ± 0.13 pmol/mg protein, respectively) but not from dermis. To confirm that the absence of dermal binding was not due to loss during the EDTA separation, we assayed skin keratomed at 0.1, 0.2, and 0.3 mm. The skin obtained at 0.1 mm was upper epidermis and exhibited binding for both retinol and retinoid acid. The 0.2 mm skin, which added lower epidermis but little dermal contamination, had higher specific activities for both retinol and retinoic acid binding. The 0.3 mm skin which added primarily dermis, had lower specific activities for binding both retinoids. This is consistent with the concept that the epidermis is responsible for the majority of retinoid binding in adult human skin obrained from the lower limb. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VITAMIN A
KW  - CARRIER proteins
KW  - RETINOIDS
KW  - EPIDERMIS
KW  - SKIN
KW  - ORGANS (Anatomy)
N1  - Accession Number: 12277185; Digiovanna, John J. 1 Fletcher, R. Theodore 2 Chader, Gerald J. 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov85, Vol. 85 Issue 5, p460; Subject Term: VITAMIN A; Subject Term: CARRIER proteins; Subject Term: RETINOIDS; Subject Term: EPIDERMIS; Subject Term: SKIN; Subject Term: ORGANS (Anatomy); Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277185
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Somerman, M.J.
AU  - Kagermer, A.S.
AU  - Bowers, M.R.
AU  - Fox, P.C.
T1  - <em>In vitro</em> attachment of bacteria to extracts of cementum.
JO  - Journal of Oral Pathology
JF  - Journal of Oral Pathology
Y1  - 1985/11//
VL  - 14
IS  - 10
M3  - Article
SP  - 793
EP  - 799
SN  - 03009777
AB  - Cementum is a specialized mineralized tissue providing for the attachment of periodontal fibers to the root surface of a tooth. In periodontal disease this connective tissue attachment to the cemental surface is lost. The ability of bacteria to adhere to the root surface, an initial event in the disease process, may be influenced by the organic matrix of cementum. Therefore, an <em>in vitro assay</em> of cell attachment was modified to study bacterial adherence to protein extracts of cementum. Petri dishes coated with the extracts were pre-incubated in culture media and then bacteria were added. Using this assay, <em>Capnocytophaga</em>-like species, a gram negative bacterium implicated in periodontal disease, attached preferentially to dishes coated with cemental extracts when compared with Type I collagen or uncoated dishes. This assay system should prove beneficial for studying the attachment of various microorganisms to protein extracts of both normal and diseased cementum, as well as providing insight into the unique attachment properties of cementum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CEMENTUM
KW  - BACTERIAL adhesion
KW  - COLLAGEN
KW  - RATS
N1  - Accession Number: 11472565; Somerman, M.J. 1 Kagermer, A.S. 2 Bowers, M.R. 1 Fox, P.C. 1; Affiliation:  1: Clinical Investigations and Patient Care Branch, National Institutes of Health, Bethesda  2: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda; Source Info: Nov85, Vol. 14 Issue 10, p793; Subject Term: CEMENTUM; Subject Term: BACTERIAL adhesion; Subject Term: COLLAGEN; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1600-0714.ep11472565
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Lowy, Douglas R.
T1  - Oncogenes Are Here to Stay.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/12//
VL  - 85
IS  - 6
M3  - Editorial
SP  - 495
EP  - 497
SN  - 0022202X
AB  - Some cancers might represent the consequence of one or several discrete genetic changes in the tumor cells. Studies of xeroderma pigmentosum cells revealed genetic lesions that predispose cells to be more susceptible to the carcinogenic effects of ultraviolet radiation. As often happens, technical innovations have led to identification and characterization of these genes. Tumor virologists carried out the initial studies of cellular oncogenes. It bad been recognized for many years that certain proteins encoded by the strongly transforming retroviruses have the capacity to directly induce tumorigenic transformation of cultured cells and endow these viruses with their high oncogenic potentials.
KW  - TUMORS
KW  - ONCOGENES
KW  - XERODERMA pigmentosum
KW  - VIROLOGISTS
KW  - RETROVIRUSES
KW  - PROTEINS
N1  - Accession Number: 12277286; Lowy, Douglas R. 1; Affiliation:  1: Laboratory of Cellular Oncology National Cancer Institute Bethesda, Maryland.; Source Info: Dec85, Vol. 85 Issue 6, p495; Subject Term: TUMORS; Subject Term: ONCOGENES; Subject Term: XERODERMA pigmentosum; Subject Term: VIROLOGISTS; Subject Term: RETROVIRUSES; Subject Term: PROTEINS; Number of Pages: 3p; Document Type: Editorial
L3  - 10.1111/1523-1747.ep12277286
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DP  - EBSCOhost
DB  - aph
ER  - 
TY  - JOUR
AU  - Stanley, John R.
AU  - Rubinstein, Nurit
AU  - Klaus-Kovtun, Vera
T1  - Epidermolysis Bullosa Acquisita Antigen Is Synthesized by Both Human Keratinocytes and Human Dermal Fibroblasts.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/12//
VL  - 85
IS  - 6
M3  - Article
SP  - 542
EP  - 545
SN  - 0022202X
AB  - In order to determine the source of epidermolysis bullosa acquisita (EBA) antigen, we studied its synthesis by human keratinocytes and fibroblasts in culture. To identify the antigen, we used the sera of 5 patients with EBA. These sera had antibodies directed against the epidermal basement membrane zone (BMZ) at titers of 5-80. The 5 sera were further characterized by immunoblotting on extracts of the epidermal BMZ. In concert with previous reports, 4 sera stained a 290 kD polypeptide, 3 sera weakly stained a 145 kD polypeptide, and 1 serum did not bind either polypeptide. To study the synthesis of the ERA antigen, cultured human keratinocytes and fibroblasts, derived from neonatal foreskins, were metabolically labeled with 14C-labeled amino acids. Radiolabeled newly synthesized proteins that were extracted from these cultures with nonionic detergent were used in an immunoprecipitation assay. The precipitated proteins were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography. All 5 EBA sera, but none of 3 bullous pemphigoid or 4 normal human sera, precipitated a 290 kD polypeptide from extracts of both keratinocytes and fibroblasts. Approximately equal amounts of this 290 kD polypeptide were precipitated from equivalent amounts of extracts from either cell type. The 290 kD polypeptide was also specifically precipitated by ERA sera from extracts of a human squamous cell carcinoma line, SCC-15. The 145 kD polypeptide was not detected in the newly synthesized proteins of any of these cell cultures. This finding suggests that the 145 kD polypeptide is not a precursor of the 290 kD polypeptide. Taken together these results demonstrate that the EBA antigen is synthesized by both human keratinocytes and fibroblasts, and is not a tissue (epidermal)-specific product. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMOLYSIS bullosa
KW  - ANTIGENS
KW  - KERATINOCYTES
KW  - FIBROBLASTS
KW  - BASAL lamina
KW  - AMINO acids
KW  - POLYACRYLAMIDE gel electrophoresis
N1  - Accession Number: 12277377; Stanley, John R. 1 Rubinstein, Nurit 1 Klaus-Kovtun, Vera 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec85, Vol. 85 Issue 6, p542; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: ANTIGENS; Subject Term: KERATINOCYTES; Subject Term: FIBROBLASTS; Subject Term: BASAL lamina; Subject Term: AMINO acids; Subject Term: POLYACRYLAMIDE gel electrophoresis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277377
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cooper, Kevin D.
AU  - Breathnach, Stephen M.
AU  - Caughman, S. Wright
AU  - Palini, Alessio G.
AU  - Waxdal, Myron J.
AU  - Katz, Stephen I.
T1  - Fluorescence Microscopic and Flow Cytometric Analysis of Bone Marrow-Derived Cells in Human Epidermis: A Search for the Human Analogue of the Murine Dendritic Thy-1+ Epidermal Cell.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/12//
VL  - 85
IS  - 6
M3  - Article
SP  - 546
EP  - 552
SN  - 0022202X
AB  - Lymphoid cells with an affinity for the epidermis (epidermotropic lymphocytes) have been proposed to play a role in the immune functions of the epidermis. However, antigen-presenting Langerhans cells (LC) and indeterminate cells are presently the only cells in the human epidermis which have been demonstrated to originate in the bone marrow. Recent studies of murine epidermis have identified a population of bone marrow-derived cells which express Thy-1 antigen and which are present in a similar density to, but distinct from, LC. We therefore sought to identify the potential human analogue of the murine Thy-1+ epidermal cell utilizing a battery of antileukocyte reagents in immunohistochemical flow cytometric, and cell sorting studies. A panel of antibodies failed to detect significant numbers of human Thy-1 antigen-bearing cells, T cells, B cells, monocytes/macrophages (other than LC), and natural killer cells in tissue sections, epidermal sheets, and epidermal cell (EC) suspensions. This was the case using EC suspensions either unfractionated or fractionated on Ficoll-Hypaque to enrich for leukocyte subpopulations. Since the nature of the murine Thy-1+ EC is uncertain, it is possible that antibodies directed against well-defined leukoeyte suhpopulations may not be of value in the detection of a potential human analogue. We therefore utilized double fluorescence staining with anti-HLe-1, an antibody which Identifies all human leukocytes, and anti-HLA-Dr (Dr), which identifies epidermal LC, in order to demonstrate a potential population of HLe-1+ Dr- non-LC, bone marrow-derived cells. The vast majority of HLe-1+ cells were HLA-Dr+ LC; these were present at a density of 608 cells/mm2 in epidermal sheets. A minor population of HLe-1+ cells which did not express HLA-Dr (HLe-1+ Dr-) was observed in tissue sections, epidermal sheets, and EC suspensions. The nondendritic morphology and low density of these HLe-1+ Dr- EC in epidermal sheets (mean density of 4.2 ± 1.6 cells/mm2) precluded their representing a strict human analogue of the murine Thy-1+ EC, since murine Thy-1+ EC are dendritic and are present in a density similar to that of LC. Purified preparations of the minor HLe-1+ Dr- EC population obtained by electronic cell sorting or panning and examined ultrastructurally were not enriched for any bone marrow-derived cell population. Thus, using currently available markers and sorting technology, we have been unable to identify a human analogue of the murine dendritic Thy-1+ epidermal cell. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BONE marrow
KW  - LYMPHOCYTES
KW  - FLUORESCENCE
KW  - FLOW cytometry
KW  - LANGERHANS cells
KW  - KILLER cells
KW  - IMMUNOHISTOCHEMISTRY
N1  - Accession Number: 12277391; Cooper, Kevin D. 1 Breathnach, Stephen M. 2 Caughman, S. Wright 3 Palini, Alessio G. 4 Waxdal, Myron J. 4 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A  2: Charing Cross and Westminster Hospital Medical School, The Reynold's Building, St. Dunstan's Road, Hammersmith, London W6 8RP, U.K.  3: Dermatology Research Labs, Room 5538, Kresge I, Box 56, Ann Arbor, Michigan 48109  4: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec85, Vol. 85 Issue 6, p546; Subject Term: BONE marrow; Subject Term: LYMPHOCYTES; Subject Term: FLUORESCENCE; Subject Term: FLOW cytometry; Subject Term: LANGERHANS cells; Subject Term: KILLER cells; Subject Term: IMMUNOHISTOCHEMISTRY; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277391
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Breathnach, Stephen M.
AU  - Katz, Stephen I.
T1  - Effect of X-irradiation on Epidermal Immune Function: Decreased Density and Alloantigen-Presenting Capacity of Ia+ Langerhans Cells and Impaired Production of Epidermal Cell-Derived Thymocyte Activating Factor (ETAF).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1985/12//
VL  - 85
IS  - 6
M3  - Article
SP  - 553
EP  - 558
SN  - 0022202X
AB  - The mechanisms involved in the modulation of cutaneous immune responses by UV radiation have been extensively investigated; by contrast, few studies have addressed the effects of x-irradiation on epidermal immune function. We therefore investigated the effect of x-irradiation of mice on: (a) the density of epidermal Ia+ Langerhans cells (LC) in immunofluorescence studies, (b) epidermal cell (EC) allostimulatory capacity in the allogeneic EC-lymphocyte reaction (ELR), and (c) production of epidermal cell-derived thymocyte activating factor (ETAF). C3H/He and BALB/c mice were irradiated with 900, 1,800, 2,700, or 3,600 rad from a 137Cs source, and sacrificed 10 h or 3 days later. X-irradiation of mice 10 h previously only slightly decreased the density of epidermal Ia+ LC and did not affect the capacity of their EC to stimulate allogeneic responder lymphocytes in the ELR. X-irradiation of mice 3 days previously, however, resulted in a dose-dependent decrease in the density of Ia+ LC. This decrease was accompanied by a substantial reduction in EC allostimulatory capacity in the ELR at all doses of x-irradiation. ETAF production by cultured EC from mice x-irradiated 3 days previously was also found to be diminished at all doses of x-irradiation. Trypan blue exclusion studies demonstrated that the observed decreases in EC allostimulatory capacity and ETAF production were not the result of a generalized lethal effect of x-irradiation on EC. The reduction in EC allostimulatory capacity following in vivo x-irradiation could not be reversed by addition of exogenous ETAF or interleukin-1 in the ELR. Taken together, these results indicate that x-irradiation decreases the density of Ia+ LC, impairs LC alloantigen-presenting function, and reduces ETAF production. Thus cutaneous x-irradiation may affect inflammatory and neoplastic processes not only by its antimitotic activity, but also by a direct effect on EC which subserve immunologic functions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - ULTRAVIOLET radiation
KW  - LANGERHANS cells
KW  - X-rays -- Therapeutic use
KW  - IMMUNOFLUORESCENCE
KW  - INTERLEUKIN-1
N1  - Accession Number: 12277399; Breathnach, Stephen M. 1 Katz, Stephen I. 2; Affiliation:  1: Department of Medicine (Dermatology), Charing Cross and Westminster Medical School, Charing Cross Hospital, Fulham Palace Road, London WG 8RF, U.K.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec85, Vol. 85 Issue 6, p553; Subject Term: IMMUNE response; Subject Term: ULTRAVIOLET radiation; Subject Term: LANGERHANS cells; Subject Term: X-rays -- Therapeutic use; Subject Term: IMMUNOFLUORESCENCE; Subject Term: INTERLEUKIN-1; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277399
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12277399&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shapiro, M. B.
AU  - Schein, S. J.
AU  - de Monasterio, F. M.
T1  - Regularity and Structure of the Spatial Pattern of Blue Cones of Macaque Retina.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/12//
VL  - 80
IS  - 392
M3  - Article
SP  - 803
SN  - 01621459
AB  - Models were developed for describing the regular pattern of blue cones in macaque retina. Two functional descriptions were applied to patterns, one based on the cdf of interpoint distances, the other on the cdf of the central angles of Voronoi regions. Disordered triangular and square lattices and hard balls failed to model the blue-cone point pattern. An elastic-ball model was developed whose spatial properties fit well those of the blue-cone pattern. This model employed a hard core and a soft surrounding shell and is proposed as a valid model for the blue-cone pattern. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LATTICE theory
KW  - LIGHT cones
KW  - MACAQUES
KW  - RETINA
KW  - VORONOI polygons
KW  - POSTERIOR segment (Eye)
KW  - PARTICLES (Nuclear physics)
KW  - POLYGONS
KW  - Ball model.
KW  - Disorder
KW  - Lattice structure
KW  - Modeling
KW  - Spatial statistics
N1  - Accession Number: 4610361; Shapiro, M. B. 1; Schein, S. J. 2; de Monasterio, F. M. 2; Affiliations: 1: Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20892.; 2: Section on Visual Processing, Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.; Issue Info: Dec85, Vol. 80 Issue 392, p803; Subject Term: LATTICE theory; Subject Term: LIGHT cones; Subject Term: MACAQUES; Subject Term: RETINA; Subject Term: VORONOI polygons; Subject Term: POSTERIOR segment (Eye); Subject Term: PARTICLES (Nuclear physics); Subject Term: POLYGONS; Author-Supplied Keyword: Ball model.; Author-Supplied Keyword: Disorder; Author-Supplied Keyword: Lattice structure; Author-Supplied Keyword: Modeling; Author-Supplied Keyword: Spatial statistics; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Campbell, Gregory
AU  - Skillings, John H.
T1  - Nonparametric Stepwise Multiple Comparison Procedures.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1985/12//
VL  - 80
IS  - 392
M3  - Article
SP  - 998
SN  - 01621459
AB  - Nonparametric multiple comparisons are discussed, with particular emphasis given to stepwise procedures. Nonparametric analogs of the stepwise all-subset procedure of Einot and Gabriel are presented, along with an ad hoc nonparametric analog of the Newman-Keuls procedure. These new procedures are compared among themselves and with nonstepwise procedures based on Type I error levels and comparisonwise power. It is shown that these stepwise nonparametric procedures control Type I error levels, and that they have superior pairwise power compared to the commonly used nonstepwise procedures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ERROR analysis (Mathematics)
KW  - NONPARAMETRIC statistics
KW  - MONTE Carlo method
KW  - STATISTICS
KW  - MATHEMATICAL statistics
KW  - SET theory
KW  - SIMULTANEOUS equations
KW  - NUMERICAL analysis
KW  - Experimentwise error rate
KW  - Monte Carlo.
KW  - Newman-Keuls
KW  - Simultaneous test procedure
KW  - Stepwise all-subset procedures
N1  - Accession Number: 4612552; Campbell, Gregory 1; Skillings, John H. 2; Affiliations: 1: Senior Staff Fellow, Laboratory of Statistical and Mathematical Methodology, Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20205.; 2: Professor, Department of Mathematics and Statistics, Miami University, Oxford, OH 45056.; Issue Info: Dec85, Vol. 80 Issue 392, p998; Thesaurus Term: ERROR analysis (Mathematics); Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: MONTE Carlo method; Thesaurus Term: STATISTICS; Thesaurus Term: MATHEMATICAL statistics; Subject Term: SET theory; Subject Term: SIMULTANEOUS equations; Subject Term: NUMERICAL analysis; Author-Supplied Keyword: Experimentwise error rate; Author-Supplied Keyword: Monte Carlo.; Author-Supplied Keyword: Newman-Keuls; Author-Supplied Keyword: Simultaneous test procedure; Author-Supplied Keyword: Stepwise all-subset procedures; Number of Pages: 6p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=4612552&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - buh
ER  - 

TY  - Gen
ID  - 9999-07197-000
AN  - 9999-07197-000
AU  - Trickett, Penelope K.
AU  - Kuczynski, Leon
T1  - Parent Daily Report
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1986///
AD  - Trickett, Penelope K., University of Southern California, Los Angeles, California, United States, 90089-0411
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-07197-000. Partial author list: First Author & Affiliation: Trickett, Penelope K.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20111212. Correction Date: 20160808. Test Format: Parents record 4 types of data following situations in which they used discipline with a misbehaving child: 'What my child did,' 'What I did,' 'What happened next,' and 'How I felt afterward.'. Language: English. Constructs: Parental Discipline Strategies; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Parent Daily Report is to allow parents to record specific details about disciplinary actions that they use with a misbehaving child.
AB  - Description: The Parent Daily Report (Trickett & Kuczynski, 1986) was created in a study investigating child misbehaviors and parental discipline. Participants were 20 abusive families with children between the ages of 4 and 10. A matched control group of 20 families also participated. This instrument consists of a page of instructions, a page of examples, and the forms on which the parent is to record. Parents are asked to think about the times they used discipline during the day, and to write about at least three of them. They are to write exactly what the child did that required discipline, exactly what they said and did in the situation, how the situation turned out for both the parent and the child, and how they felt about the situation. These instructions were followed by a list of 'common child misbehaviors' such as fighting with others and whining. Parents were instructed to record their observations for 5 consecutive days. The transcripts of discipline episodes were coded by a rater blind to group membership in terms of type of child misbehavior, type of parental discipline, nature of child's compliance or noncompliance to the parental intervention, and nature of parent affective response to the situation. For the purposes of estimating intercoder reliability, transcripts of 22 parents were independently recoded. The percentage of agreement between the two independent coders ranged from 80% for the child compliance categories to 94% for parental affective response. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Children's Misbehaviors
KW  - Parent Daily Report
KW  - Parental Discipline Strategies
KW  - Psychometric Properties
KW  - Test Development
U5  - Parent Daily Report [Test Development]Children's misbehaviors and parental discipline strategies in abusive and nonabusive families. (AN: 1986-12115-001 from PsycINFO) Trickett, Penelope K.; Kuczynski, Leon; Jan, 1986. Source: Developmental Psychology. 22(1), American Psychological Association, US; Jan, 1986; Administration: Paper Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs), School Age (6-12 yrs); Population: Human; Male; Female; Location: United States; Sample: Families with a Child between the Ages of 4 and 11 Keywords: Children's Misbehaviors; Parent Daily Report; Parental Discipline Strategies; Psychometric Properties; Test Development; Subjects: Behavior Problems; Child Discipline; Coercion; Daily Activities; Parenting; Self-Report; Test Construction;
DO  - 10.1037/t07197-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07197-000&site=ehost-live&scope=site
UR  - pennyt@usc.edu
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-07777-000
AN  - 9999-07777-000
AU  - Whitehead, William E.
AU  - Busch, Catherine M.
AU  - Heller, Barbara R.
AU  - Costa, Paul T. Jr.
T1  - Menstrual History Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1986///
AD  - Whitehead, William E.
AV  - Commercial: No; Permissions: Contact Publisher; Fee: Unknown. Test Items: No
N1  - Accession Number: 9999-07777-000. Partial author list: First Author & Affiliation: Whitehead, William E.; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States. Release Date: 20120109. Instrument Type: Inventory/Questionnaire. Test Format: For each item, the response possibilities were Never; Rarely, once or twice a year, if symptoms were severe; Sometimes, 3 to 6 times per year, if symptoms were worse than usual; and Often, more than 6 times per year.. Language: English. Constructs: Menstrual Symptoms; Modeling of Illness Behavior; Classification: Physical Health/Illness Related Assessment (7300); Family Relationships and Parenting (6100). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Menstrual History Questionnaire is to assess behaviors of mothers that influence menstrual symptoms and illness behavior in daughters.
AB  - Description: The Menstrual History Questionnaire (Whitehead et al., 1986) assesses parent behaviors that encouraged adoption of the sick role in women. Four questions were available from a previous survey that discriminated between people who made multiple somatic complaints from people who made few (Whitehead et al., 1982). Using these questions as models, a new set of eight items describing parental responses to menstrual symptoms and four items describing maternal modeling of the menstrual sick role were written. The items on cold symptoms were retained, making three subscales. Two versions of this questionnaire were developed—one to be completed by a nursing student sample and the other to be completed independently by their mothers. Modeling of sick role behavior for nonmenstrual symptoms during childhood was assessed by an open-ended question as to whether any member of the immediate family had a chronic illness before the respondent was 15 years of age. The Menstrual History Questionnaire also asked subjects (a) to identify the frequency of absences from school or work due to illness during the preceding year, (b) to list the illnesses for which they sought medical treatment in the past year, and (c) to identify menstrual and gynecological disorders since age 15 for which medical treatment was sought. A principal components analysis of the daughters' responses to the social learning items resulted in four components with eigenvalues greater than 1. Varimax rotation resulted in three components interpreted to represent the three social learning scales—encouragement of sick role behaviors for menstrual symptoms (six items), encouragement of sick role behaviors for cold symptoms (four items), and modeling of the menstrual sick role (four items). The fourth component consisted of only two items and was not used for further analyses. Using the daughters' responses, the alpha reliabilities for the three scales were .81, .79, and .82, respectively. Results for the mothers' responses were similar. The agreement between mothers and their daughters was estimated by computing the correlation between scores on the subscales. This provided a measure of convergent validity. (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW  - Menstrual History Questionnaire
KW  - Sick Role Behaviors
KW  - Social Learning Influences
KW  - Test Development
KW  - Psychometric Properties
U5  - Menstrual History Questionnaire [Test Development]Social learning influences on menstrual symptoms and illness behavior. (AN: 1987-21629-001 from PsycINFO) Whitehead, William E.; Busch, Catherine M.; Heller, Barbara R.; Costa, Paul T.; 1986. Source: Health Psychology. 5(1), Lawrence Erlbaum Associates, US; 1986; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs); Population: Human; Female; Sample: Daughters and Mothers Aged 18 to 39 Keywords: Menstrual History Questionnaire; Sick Role Behaviors; Social Learning Influences; Test Development; Psychometric Properties; Subjects: Family History; Illness Behavior; Menstruation; Mother Child Relations; Questionnaires; Social Influences; Social Learning; Test Construction;
DO  - 10.1037/t07777-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07777-000&site=ehost-live&scope=site
UR  - william_whitehead@med.unc.edu
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-14586-000
AN  - 9999-14586-000
AU  - Berg, Carol J.
AU  - Rapoport, Judith L.
AU  - Flament, Martine
T1  - Leyton Obsessional Inventory Survey—Child Version
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1986///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-14586-000. Acronyms: LOI-C. Partial author list: First Author & Affiliation: Berg, Carol J.; National Institute of Mental Health, Child Psychiatry Branch, Bethesda, Maryland, United States. Release Date: 20120910. Correction Date: 20151109. Instrument Type: Survey. Test Format: In the Leyton Obsessional Inventory Survey—Child Version if the respondent indicates 'yes' to an item, they then rate that item on a 4-point scale.. Language: English. Constructs: Obsessive Compulsive Disorder; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Female (40); Male (30). Age Group: Adolescence (13-17 yrs) (200); Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Other Versions: 9999-33581-000, Leyton Obsessional Inventory—Child Chinese Version, Translation. 
N2  - Administration Method: Paper
AB  - Purpose: The Leyton Obsessional Inventory Survey—Child Version differentiates obsessive child patients from normal controls on total scores for obsessional symptoms as well as total scores for degree of resistance to the symptoms and interference with everyday life.
AB  - Description: The Leyton Obsessional Inventory Survey—Child Version (LOI-CV; Berg, Rapoport, & Flament, 1986) consists of 44, or 20 items that are designed to distinguish adolescents with Obsessional-Compulsive Disorder (OCD) from both psychiatric patients as well as from normal controls. The 20-item version demonstrated high internal reliability with Cronbach's alpha of 0.81. Pearson product moment correlations for 'yes' and total obsessive responses (TO) for the entire goup, males, and females, were r = 0.88-0.89 and for interference and TO responses, r = 0.95 to 0.96, demonstrating that the TO scores are interchangeable with 'yes' and interference scores for factor analyses. Four factors accounted for 47% of the variance in the principal components factor analysis: 1. general obsessive, 2. dirt-contamination, 3. numbers-luck, and 4. school. In the 44-item version, obsessive patients showed higher resistance scores and a trend for higher interference scores from psychiatric controls. Correlations between 'yes' scores with resistance and interference for all groups gave coefficients of r = 0.83, 0.86 while resistance and interference were r = 0.86. The correlations for the individuals groups ranged from r = 0.73 to 0.88. Correlations of the LOI-CV scores and scores of Obsessive Compulsive Rating Scale (OCR), Comprehensive Psychopathological Rating Scale (CPRS-OC), and NIMH Obsessive Compulsive Scale (NIMH-OC) were r = 0.77 to 0.89, and NIMH Global Scale (NIMH-G) were r = 0.69 to 0.77. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Leyton Obsessional Inventory Survey—Child Version
KW  - Obsessive Compulsive Disorder
KW  - Obsessions
KW  - Screening Tests
KW  - Test Development
KW  - Internal Consistency
KW  - Test Reliability
KW  - Test Validity
KW  - Disgust Sensitivity
KW  - Psychopathological Symptoms
U5  - Leyton Obsessional Inventory Survey—Child Version (LOI-C) [Test Development]The survey form of the Leyton Obsessional Inventory—Child Version: Norms from an epidemiological study. (AN: 1989-21065-001 from PsycINFO) Berg, Carol Z.; Whitaker, Agnes; Davies, Mark; Flament, Martine F.; Rapoport, Judith L.; Nov, 1988. Source: Journal of the American Academy of Child & Adolescent Psychiatry. 27(6), Lippincott Williams & Wilkins, US; Nov, 1988; Administration: Paper Age Group: Adolescence (13-17 yrs); Population: Human; Female; Male; Sample: 9th through 12th Grade Students; Location: United States Keywords: Leyton Obsessional Inventory Survey—Child Version; Obsessive Compulsive Disorder; Obsessions; Screening Tests; Test Development; Internal Consistency; Subjects: Obsessions; Obsessive Compulsive Disorder; Screening Tests; Test Construction; Test Reliability;
U5  - Leyton Obsessional Inventory Survey—Child Version (LOI-C) [Test Development]The Leyton Obsessional Inventory—Child Version. (AN: 1987-02850-001 from PsycINFO) Berg, Carol J.; Rapoport, Judith L.; Flament, Martine; Jan, 1986. Source: Journal of the American Academy of Child Psychiatry. 25(1), Lippincott Williams & Wilkins, US; Jan, 1986; Administration: Paper Age Group: Adolescence (13-17 yrs); Population: Human; Male; Female; Sample: Adolescent Obsessive-Compulsive Disorder Patients Keywords: Leyton Obsessional Inventory Survey—Child Version; Obsessive Compulsive Disorder; Obsessions; Screening Tests; Test Development; Test Reliability; Test Validity; Subjects: Child Psychology; Obsessions; Obsessive Compulsive Disorder; Screening Tests; Test Construction; Test Reliability; Test Validity;
U5  - Leyton Obsessional Inventory Survey—Child Version (LOI-C) [Test Use]Disgust sensitivity and psychopathological symptoms in non-clinical children. (AN: 2008-04005-003 from PsycINFO) Muris, Peter; van der Heiden, Simone; Rassin, Eric; Jun, 2008. Source: Journal of Behavior Therapy and Experimental Psychiatry. 39(2), Elsevier Science, Netherlands; Jun, 2008; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs); Population: Human; Male; Female; Sample: Primary School Children (9-13 Years Old) Keywords: Leyton Obsessional Inventory Survey—Child Version; Disgust Sensitivity; Psychopathological Symptoms; Subjects: Child Psychopathology; Emotions; Obsessions; Obsessive Compulsive Personality Disorder;
DO  - 10.1037/t14586-000
L3  - Full; Full text; 999914586_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-14586-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-07472-000
AN  - 9999-07472-000
AU  - Bernstein, Eve M.
AU  - Putnam, Frank W.
T1  - Dissociative Experiences Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1986///
AD  - Bernstein, Eve M.
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-07472-000. Acronyms: DES. Partial author list: First Author & Affiliation: Bernstein, Eve M.; American University, Department of Psychology, Washington, District of Columbia, United States. Release Date: 20130107. Correction Date: 20150608. Instrument Type: Rating Scale. Test Format: Respondents make slashes on 100-mm lines to indicate where they fall on a continuum for each question.. Language: English. Constructs: Dissociation; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Other Versions: 9999-40219-000, Dissociative Experiences Scale—Arabic Version, Translation. 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Dissociative Experiences Scale is to measure dissociation in normal and clinical populations.
AB  - Description: The Dissociative Experiences Scale (DES; Bernstein & Putnam, 1986) was developed to offer a means of reliably measuring dissociation in normal and clinical populations. Scale items were developed using clinical data and interviews, scales involving memory loss, and consultations with experts in dissociation. Pilot testing was performed to refine the wording and format of the scale. The scale is a 28-item self-report questionnaire. Subjects were asked to make slashes on 100-mm lines to indicate where they fall on a continuum for each question. In addition, demographic information (age, sex, occupation, and level of education) was collected so that the connection between these variables and scale scores could be examined. The mean of all item scores ranges from 0 to 100 and is called the DES score. The scale was administered to between 10 and 39 subjects in each of the following populations: normal adults, late adolescent college students, and persons suffering from alcoholism, agoraphobia, phobicanxious disorders, posttraumatic stress disorder, schizophrenia, and multiple personality disorder. Reliability testing of the scale showed that the scale had good test-retest and good split-half reliability. Item-scale score correlations were all significant, indicating good internal consistency and construct validity. A Kruskal-Wallis test and post hoc comparisons of the scores of the eight populations provided evidence of the scale's criterion-referenced validity. The scale was able to distinguish between subjects with a dissociative disorder (multiple personality) and all other subjects. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Dissociative Experiences Scale
KW  - Psychological Assessment
KW  - Test Development
KW  - Test Reliability
KW  - Test Validity
KW  - Factor Structure
KW  - Dissociative Pathology
KW  - Dissociation
U5  - Dissociative Experiences Scale (DES) [Test Development]Development, reliability, and validity of a dissociation scale. (AN: 1987-14407-001 from PsycINFO) Bernstein, Eve M.; Putnam, Frank W.; Dec, 1986. Source: Journal of Nervous and Mental Disease. 174(12), Lippincott Williams & Wilkins, US; Dec, 1986; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Late Adolescent College Students Keywords: Dissociative Experiences Scale; Psychological Assessment; Test Development; Test Reliability; Test Validity; Subjects: Dissociation; Dissociative Disorders; Psychological Assessment; Test Construction; Test Reliability; Test Validity;
U5  - Dissociative Experiences Scale (DES) [Test Review]Confirmatory factor analysis of single- and multiple-factor competing models of the Dissociative Experiences Scale in a nonclinical sample. (AN: 2002-01707-010 from PsycINFO) Stockdale, Gary D.; Gridley, Betty E.; Balogh, Deborah Ware; Holtgraves, Thomas; Mar, 2002. Source: Assessment. 9(1), Sage Publications, US; Mar, 2002; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: University Students Keywords: Dissociative Experiences Scale; Factor Structure; Dissociative Pathology; Dissociation; Subjects: Dissociative Disorders; Experiences (Events); Factor Structure; Psychopathology; Screening Tests; Test Validity;
DO  - 10.1037/t07472-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07472-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-29427-000
AN  - 9999-29427-000
AU  - Levine, Jerome
AU  - Schooler, Nina R.
T1  - Systematic Assessment for Treatment Emergent Events−Specific Inquiry
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1986///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No
N1  - Accession Number: 9999-29427-000. Acronyms: SAFTEE-SI. Partial author list: First Author & Affiliation: Levine, Jerome; University of Maryland, Department of Psychiatry, Baltimore, Maryland, United States. Release Date: 20170109. Test Format: The SAFTEE-SI comprises 78 items and consists of standardized, structured interview questions, checklists, and a five-point Likert-type scale ranging from 1 (none/minimal) to 5 (very severe).. Language: English. Constructs: Treatment Emergent Events; Treatment Side Effects; Classification: Treatment, Rehabilitation, and Therapeutic Processes (7900). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Interview
AB  - Purpose: The Systematic Assessment for Treatment Emergent Events−Specific Inquiry is designed to assess side effects that emerge during clinical trials.
AB  - Description: The Systematic Assessment for Treatment Emergent Events−Specific Inquiry (SAFTEE-SI; Levine & Schooler, 1986) was developed in an effort to improve the precision with which side effects are assessed during clinical trials. The SAFTEE-SI is one of two versions; the other is the Systematic Assessment for Treatment Emergent Events−General Inquiry (SAFTEE-GI; Levine & Schooler, 1986). The SAFTEE-GI is designed to be a global measure, while the SAFTEE-SI is more detailed. The GI is an open-ended inquiry about 'any physical or health problems experienced during the past week.' The SI includes the administration of the GI, which is always asked first. The SI then presents questions in 23 categories, with two or more specific questions in each, for a total of 78 questions. The SAFTEE categories are organized more or less by organ system or body part (head, eyes/vision, ears/hearing, mouth, chest, heart, stomach, etc.). The last few categories concern sleeping, memory, concentration, and mood. This systematic and specific inquiry about all body parts and organ systems avoids the pitfall of the investigator having to know in advance what side effects to expect. The questions are standardized and presented in the precise form they are to be asked of the patient. In addition, raters are asked to choose from a list of 76 'preferred event terms' to record reported events rather than their own term or the patient's words. The SAFTEE-SI also captures information regarding the onset, duration, pattern, severity, attribution of cause, and action taken by the clinician in response to the event. Collection of this information is facilitated with precoded responses to each category of information and a series of suggested probe questions. There is also space for 'study specific' inquiries to be written in and for responses to be recorded. The SI takes 15−20 minutes to administer. No psychometric data regarding the development of the SAFTEE-SI are reported in the Levine & Schooler (1986) development citation, nor in a comparison of the SI and GI forms reported by Rabkin et al., (1992). (PsycTESTS Database Record (c) 2017 APA, all rights reserved)
KW  - Adverse Health Events
KW  - Attribution of Cause
KW  - Checklist
KW  - Clinical Events
KW  - Duration
KW  - Even Severity
KW  - Event Content
KW  - Event Type
KW  - Form Comparison
KW  - General Inquiry Form
KW  - Medication Side Effects
KW  - SAFTEE-SI
KW  - SAFTEE-GI
KW  - Severity
KW  - Systematic Assessment for Treatment Emergent Events−Specific Inquiry
KW  - Systematic Inquiry Form
U5  - Systematic Assessment for Treatment Emergent Events−Specific Inquiry (SAFTEE-SI) [Test Review]General versus systematic inquiry about emergent clinical events with SAFTEE: Implications for clinical research. (AN: 1992-28452-001 from PsycINFO) Rabkin, Judith G.; Markowitz, Jeffrey S.; Ocepek-Welikson, Katje; Wager, Steven S.; Feb, 1992. Source: Journal of Clinical Psychopharmacology. 12(1), Lippincott Williams & Wilkins, US; Feb, 1992; Administration: Interview Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Samples: Patients Treated with Imipramine, Phenelzine, Or Placebo in Clinical Trials Keywords: Adverse Health Events; Attribution of Cause; Checklist; Clinical Events; Duration; Even Severity; Event Content; Event Type; Form Comparison; General Inquiry Form; Medication Side Effects; SAFTEE-SI; SAFTEE-GI; Severity; Systematic Assessment for Treatment Emergent Events−Specific Inquiry; Systematic Inquiry Form; Subjects: Checklist (Testing); Clinical Trials; Drug Therapy; Evaluation; Imipramine; Patient Safety; Phenelzine; Placebo; Side Effects (Drug); Structured Clinical Interview; Test Forms;
DO  - 10.1037/t29427-000
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Wetzel, M.G.
T1  - Progress in Retinal Research (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1986/01//Jan/Feb86
VL  - 74
IS  - 1
M3  - Book Review
SP  - 92
EP  - 92
SN  - 00030996
AB  - Reviews the book 'Progress in Retinal Research,' edited by Neville N. Osborne and Gerald J. Chandler.
KW  - Retina
KW  - Nonfiction
KW  - Progress in Retinal Research (Book)
N1  - Accession Number: 11232292; Wetzel, M.G. 1; Affiliations: 1: National Eye Institute, National Institutes of Health; Issue Info: Jan/Feb86, Vol. 74 Issue 1, p92; Subject Term: Retina; Subject Term: Nonfiction; Reviews & Products: Progress in Retinal Research (Book); Number of Pages: 1/4p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Santos, Eugenio
T1  - ONCOGENE RESEARCH.
JO  - BioScience
JF  - BioScience
Y1  - 1986/01//
VL  - 36
IS  - 1
M3  - Book Review
SP  - 55
EP  - 56
SN  - 00063568
AB  - Reviews the book "Genes and Cancer," by Alan R. Liss, edited by J. Michael Bishop, Janet D. Rowley, and Mel Greaves.
KW  - Cancer genetics
KW  - Nonfiction
KW  - Liss, Alan
KW  - Genes & Cancer (Book)
N1  - Accession Number: 10094813; Santos, Eugenio 1; Affiliations: 1: Frederick Cancer Research Facility, National Cancer Institute, P.O. Box B, Frederick, MD 21701; Issue Info: Jan1986, Vol. 36 Issue 1, p55; Subject Term: Cancer genetics; Subject Term: Nonfiction; Reviews & Products: Genes & Cancer (Book); People: Liss, Alan; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 950
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Brown, J.
AU  - Whittle, H. C.
AU  - Berzins, K.
AU  - Howard, R. J.
AU  - Marsh, K.
AU  - K. Sjoberg
T1  - Inhibition of Plasmodium falciparum growth by IgG antibody produced by human lymphocytes transformed with Epstein-Barr virus.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1986/01//
VL  - 63
IS  - 1
M3  - Article
SP  - 135
EP  - 140
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Supernatants from Epstein-Barr virus (EBV)-stimulated B lymphocytes obtained from two adult Gambians who were partially immune to malaria markedly inhibited the growth of Plasmodium falciparum in vitro (55-95% inhibition). When 22 separate colonies were derived by micromanipulation from one of these primary cultures and their supernatants assayed, the degree of inhibition correlated with levels of IgG fluorescent antibody and total IgG. The inhibitory anti-P. falciparum IgG immunoprecipitated an antigen of mol. wt 195,000, identified as the major schizont surface glycoprotein by dual biosynthetic labelling with 3H-glucosamine or -35S-methionine. Other studies on the analogous schizont surface protein of rodent malarias have shown that this antigen stimulates protective immunity. Production of this inhibitory antibody by adult Gambians may therefore contribute to their immunity to malaria. Human antibodies produced by EBV-stimulated B lymphocytes may be used to identify other important P. falciparum antigens and have potential applications for immunotherapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MALARIA
KW  - IMMUNOGLOBULIN G
KW  - PLASMODIUM falciparum
KW  - PROTOZOAN diseases
KW  - IMMUNOGLOBULINS
KW  - GLUCOSAMINE
KW  - MICRURGY
KW  - B lymphocyte culture supernatants growth inhibition
KW  - Epstein-Barr virus
KW  - falciparum malaria
N1  - Accession Number: 16003925; Brown, J. 1 Whittle, H. C. 1 Berzins, K. 2,3 Howard, R. J. 2,3 Marsh, K. 1 K. Sjoberg 2,3; Affiliation:  1: Medical Research Council Laboratories, Fajara, The Gambia, West Africa.  2: Department of Immunology, Wenner Gren Institute, University of Stockholm, Sweden  3: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Jan1986, Vol. 63 Issue 1, p135; Subject Term: MALARIA; Subject Term: IMMUNOGLOBULIN G; Subject Term: PLASMODIUM falciparum; Subject Term: PROTOZOAN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: GLUCOSAMINE; Subject Term: MICRURGY; Author-Supplied Keyword: B lymphocyte culture supernatants growth inhibition; Author-Supplied Keyword: Epstein-Barr virus; Author-Supplied Keyword: falciparum malaria; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Smalley, R. V.;
AU  - Oldham, R. K.;
T1  - Phase I trials of biological response modifiers
CT  - Phase I trials of biological response modifiers
JO  - Drugs under Experimental and Clinical Research (Switzerland)
JF  - Drugs under Experimental and Clinical Research (Switzerland)
Y1  - 1986/01/01/
VL  - 12
IS  - Feb
SP  - 31
EP  - 39
SN  - 03786501
AD  - Biological Response Modifiers Program, Frederick Cancer Res. Facility, National Cancer Institute, Frederick, MD 21701
N1  - Accession Number: 24-06780; Language: English; References: 32; Journal Coden: DECRDP; Section Heading: Methodology; Drug Evaluations; Abstract Author: D. L. Thompson
N2  - The methodology of clinical trials evaluating biological response modifiers, e.g., interferons, monoclonal antibodies, and immunoconjugates, was discussed.
KW  - Interferons--clinical studies--methodology;
KW  - Antibodies--monoclonal--clinical studies, methodology;
KW  - Immunoconjugates--clinical studies--methodology;
KW  - Methodology--clinical studies--biological response modifiers;
KW  - Clinical studies--methodology--biological response modifiers;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lew, A. M.
AU  - Lillehoj, E. P.
AU  - Cowan, E. P.
AU  - Maloy, W. L.
AU  - Van Schravendijk, M. R.
AU  - Coligan, J. E.
T1  - Class I genes and molecules: an update.
JO  - Immunology
JF  - Immunology
Y1  - 1986/01//
VL  - 57
IS  - 1
M3  - Article
SP  - 3
EP  - 18
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The article presents information on class I genes and molecules. Class I molecules of the major histocompatibility complex were the first molecules identified as targets for the rejection of tissue grafts. Since this initial observation, extensive studies have produced considerable insight into the structure and function of this highly diverse family of molecules. The remarkable hallmark of the class I family is its unparalleled degree of genetic polymorphism and diversity. The polymorphism is reflected by the fact that multiple loci encode class I molecules, and for each locus there can be upwards of 100 alleles. The purpose of this article is to assimilate the information accumulated on the class I molecules since previous reviews.
KW  - GENETIC polymorphisms
KW  - GENES
KW  - MOLECULES
KW  - IMMUNITY
KW  - IMMUNOLOGY
KW  - POPULATION genetics
N1  - Accession Number: 14004172; Lew, A. M. 1 Lillehoj, E. P. 1 Cowan, E. P. 1 Maloy, W. L. 1 Van Schravendijk, M. R. 2 Coligan, J. E. 1; Affiliation:  1: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Tropical Medicine Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford U.K.; Source Info: Jan1986, Vol. 57 Issue 1, p3; Subject Term: GENETIC polymorphisms; Subject Term: GENES; Subject Term: MOLECULES; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; Subject Term: POPULATION genetics; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - WEINGARTNER, HERBERT
T1  - THE ROOTS OF FAILURE.
JO  - Psychology Today
JF  - Psychology Today
Y1  - 1986/01//
VL  - 20
IS  - 1
M3  - Article
SP  - 6
EP  - 7
SN  - 00333107
AB  - The article cites a research study regarding the aspects of memory failure conducted by the U.S. National Institutes of Health. Its describes the aim of study to establish a relationship between brain function changes and memory failure by comparison of various memory disorders, impact of drugs for changing cognitive processes, and role of drugs for reducing memory failure. It concludes that drugs effective in increasing brain peptides are to be further tested on their ability to enhance memory.
KW  - MEMORY -- Research
KW  - BRAIN abnormalities
KW  - DRUGS -- Effectiveness
KW  - PEPTIDES
KW  - UNITED States
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 52929841; WEINGARTNER, HERBERT 1; Affiliation:  1: Chief of Laboratory, Cognition and Human Performance, National Institute on Drug Abuse, Baltimore, Md.; Source Info: Jan86, Vol. 20 Issue 1, p6; Subject Term: MEMORY -- Research; Subject Term: BRAIN abnormalities; Subject Term: DRUGS -- Effectiveness; Subject Term: PEPTIDES; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
AU  - Slomeznski, Kazimierz M.
AU  - Schoenbach, Carrie
T1  - Social Stratification and the Transmission of Values in the Family: A Cross–National Assessment.
JO  - Sociological Forum
JF  - Sociological Forum
Y1  - 1986///Winter86
VL  - 1
IS  - 1
M3  - Article
SP  - 73
PB  - Wiley-Blackwell
SN  - 08848971
AB  - For both the U.S. and Poland, we develop measurement models of the family's social-stratification position and of parents' and children's valuations of self-direction. We find that the relationship between parents' and children's values is much stronger than past studies had indicated. In both countries the family's stratification position has an impressive bearing on the values of its adolescent and young-adult offspring. Much of this impact is through social stratification affecting parents values, and parents' values, in turn, affecting children's values. Social stratification affects parental values primarily because of the impact of parents' occupational self-direction on their values. Although parents' and children's values may he reciprocally related, the predominant effects are from parents' to children's values. The one notable cross-national difference we find is in the relative roles of fathers and mothers in the intergenerational transmission of values: in the United States, fathers play at least as important a role as do mothers; in Poland, mothers play the predominant role. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Sociological Forum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL stratification
KW  - SOCIAL classes
KW  - SOCIAL status
KW  - SOCIAL structure
KW  - UNITED States
KW  - POLAND
KW  - FAMILY RELATIONS AND COMMUNICATION
N1  - Accession Number: 10793684; Kohn, Melvin L. 1 Slomeznski, Kazimierz M. 2 Schoenbach, Carrie 3; Affiliation:  1: The Johns Hopkins University and National Institute of Mental Health.  2: University of Warsaw National Institute of Mental Health Carrie Schoenbach.  3: National Institute of Mental Health.; Source Info: Winter86, Vol. 1 Issue 1, p73; Subject Term: SOCIAL stratification; Subject Term: SOCIAL classes; Subject Term: SOCIAL status; Subject Term: SOCIAL structure; Subject Term: UNITED States; Subject Term: POLAND; Author-Supplied Keyword: FAMILY RELATIONS AND COMMUNICATION; Number of Pages: 30p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Vijay, Inder K.
AU  - Oka, Takami
T1  - Developmental regulation of glycosyltransferases involved in biosynthesis of asparagine-linked glycoproteins in mouse mammary gland.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1986/01/02/
VL  - 154
IS  - 1
M3  - Article
SP  - 57
EP  - 62
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Three glycosyltransferases, namely N-acetylglucosaminyl-1-phosphotransferase, mannosyltransferase and glucosyltransferase, involved in the biosynthesis of asparagines-linked glycoproteins in the mouse mammary gland, were identified by characterization of the products formed by these enzymes. The tissue capacities of the glycosyltransferases, measured as pmol product formed g tissue-1 min-1, increase during developmental cycle of the gland until, at late lactational stage, they reach more than 34, 14 and 60 times, respectively, the basal level found in the tissue of virgin animals. Among the three enzymes at late lactational stage the specific activities of glucosyltransferase and N-acetylglucosaminyl-1-phosphotransferase increase 7-fold and 4-fold respectively, whereas mannosyltransferase shows a mere 1.4-fold increase during tissue development. All of the enzymes, both in terms of tissue capacity and specific activity, return to the basal levels of the virgin gland one month after the end of lactation. The activities of the three enzymes in the lactating gland decrease precipitously following treatment of mice with bromocriptine, a drug that interferes with the release of prolactin from the pituitary gland and thereby inhibits milk synthesis and secretion. These results indicate that the three glycosyltransferases are developmentally regulated during the growth and differentiation of the mouse mammary gland. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLYCOSYLTRANSFERASES
KW  - BIOSYNTHESIS
KW  - GLYCOPROTEINS
KW  - MAMMARY glands
KW  - MICE as laboratory animals
KW  - LACTATION
N1  - Accession Number: 13928516; Vijay, Inder K. 1 Oka, Takami 1; Affiliation:  1: Laboratory of Molecular and Cellular Biology, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 1/2/86, Vol. 154 Issue 1, p57; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: BIOSYNTHESIS; Subject Term: GLYCOPROTEINS; Subject Term: MAMMARY glands; Subject Term: MICE as laboratory animals; Subject Term: LACTATION; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - D'Incalci, Maurizio
AU  - Allavena, Paola
AU  - Wu, Roy S.
AU  - Bonner, William M.
T1  - H1 variant synthesis in proliferating and quiescent human cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1986/01/15/
VL  - 154
IS  - 2
M3  - Article
SP  - 273
EP  - 279
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The synthesis of histone H1 isoprotein species in human cells of several different types and in several different physiological states was studied. Up to five H1 and two H1° isoprotein species could be resolved by two dimensional electrophoresis. All five H1 isoprotein species were synthesized in exponentially growing cultures of IMR-90 human fibroblasts; in quiescent IMR-90 cells the synthesis of three H1 isoprotein species was greatly decreased while the synthesis of two others was much less affected. When DNA synthesis in exponentially growing cultures of IMR-90 was inhibited, the pattern of H1 isoprotein synthesis became similar to that found in quiescent cultures. Other human cells, isolated from blood, yielded similar results. These results suggest that the pattern of H1 synthesis is the same for cells in non-S phases of the cell cycle and in quiescent cells. Thus for histone H1 in human cells the relationship of the variant synthesis pattern to the growth state and DNA replication is similar to that of the core histone H3 but not that of H2A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTONES
KW  - BASIC proteins
KW  - CELLS
KW  - ELECTROPHORESIS
KW  - ELECTROCHEMISTRY
KW  - GENES
KW  - DNA
N1  - Accession Number: 13930428; D'Incalci, Maurizio 1 Allavena, Paola 1 Wu, Roy S. 1 Bonner, William M. 1; Affiliation:  1: Laboratory of Molecular Pharmacology, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda.; Source Info: 1/15/86, Vol. 154 Issue 2, p273; Subject Term: HISTONES; Subject Term: BASIC proteins; Subject Term: CELLS; Subject Term: ELECTROPHORESIS; Subject Term: ELECTROCHEMISTRY; Subject Term: GENES; Subject Term: DNA; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Das, Pijush K.
AU  - Murray, Gary J.
AU  - Barranger, John A.
T1  - Studies n the turnover of glucocerebrosidase in cultured rat peritoneal macrophages and normal human fibroblasts.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1986/01/15/
VL  - 154
IS  - 2
M3  - Article
SP  - 445
EP  - 450
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The kinetics of glucocerebrosidase synthesis and degradation in rat peritoneal macrophages and in human fibroblasts have been studied using conduritol B epoxide (CBE), an irreversible and specific inhibitor of mammalian glucocerebrosidase. In cultured fibroblasts, higher concentrations of CBE and/or longer times were required for inhibition of glucocerebrosidase than were necessary for inhibition of the macrophage enzyme. However, inhibition of activity in cell extracts from both cell types showed identical time and concentration dependence. After the removal of CBE from cultures, enzyme activity returned to normal with a half-time of 48 h for macrophages and 40 h for fibroblasts. The reappearance of enzyme activity was prevented by an inhibitor of protein synthesis. Both the rate of synthesis and degradation of glucocerebrosidase enzyme protein were independent of the presence of CBE. The calculated rate of degradation of glucocerebrosidase was confirmed using metabolically labelled enzyme in cell cultures. The rate of synthesis for macrophages is 1.8 ng enzyme h-1 mg cell protcin-1 and the rate of degradation is 1.4% h-1 (0.014 h-1). These values were 2.0 ng h -1 mg -1 and 0.018 h -1 for fibroblasts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CULTURES (Biology)
KW  - MACROPHAGES
KW  - HUMAN beings
KW  - FIBROBLASTS
KW  - CONNECTIVE tissue cells
KW  - EPOXY compounds
N1  - Accession Number: 13930692; Das, Pijush K. 1 Murray, Gary J. 1 Barranger, John A. 1; Affiliation:  1: Developmental and Metabolic Neurology Branch, National Institutes of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.; Source Info: 1/15/86, Vol. 154 Issue 2, p445; Subject Term: CULTURES (Biology); Subject Term: MACROPHAGES; Subject Term: HUMAN beings; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; Subject Term: EPOXY compounds; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Heird, William C.
AU  - Grundy, Scott M.
AU  - Hubbard, Van S.
T1  - Structured lipids and their use in clinical nutrition.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/02//
VL  - 43
IS  - 2
M3  - Article
SP  - 320
EP  - 324
SN  - 00029165
AB  - The article offers information about structured lipids and their use in clinical nutrition. The structured lipid emulsions contain medium-chain fatty acids (MCFAs) are produced by mixing fractionated medium-chain triglyceride (MCT) and long-chain triglycerides (LCT) in specific proportions, allowing hydrolysis of the fatty acids, followed by random transesterification into composite triglyceride molecules. Individual triglyceride molecules within the
KW  - Nutrition
KW  - Lipids
KW  - Lipid metabolism
KW  - Triglycerides
KW  - Glycerides
N1  - Accession Number: 90667984; Heird, William C. 1; Grundy, Scott M. 2; Hubbard, Van S. 3; Affiliations: 1: Columbia University College of Physicians and Surgeons; 2: University of Texas Health Science Center, Dallas; 3: Director Nutrition Program, NIADDK, Westwood Building, Rcom 3A18B, National Institutes of Health, Bethesda, MD 20892; Issue Info: Feb1986, Vol. 43 Issue 2, p320; Thesaurus Term: Nutrition; Subject Term: Lipids; Subject Term: Lipid metabolism; Subject Term: Triglycerides; Subject Term: Glycerides; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ederer, Fred
AU  - Krueger, Dean E.
AU  - Mowery, Richard L.
AU  - Connett, John
AU  - Wentworth, Deborah
T1  - Lessons from the Visual Acuity Impairment Survey Pilot Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/02//
VL  - 76
IS  - 2
M3  - Article
SP  - 160
EP  - 165
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The Visual Acuity Impairment Survey (VAIS) pilot study was carried out in three large metropolitan areas of the United States to determine whether it would be feasible to conduct a large two-stage survey of the prevalence of visual acuity impairment and its causes. The study was conducted in conjunction with the Health Interview Survey (HIS), performed by the National Center for Health Statistics and the Census Bureau.  In the first stage, a simple vision screening test was administered to 1,868 adults in their homes by specially trained Census Bureau interviewers. All those who failed the test, and a sample of those who passed it, were invited to a local clinic for a check on the accuracy of the screen and a detailed eye examination to establish the cause of the impairment. About 89 per ¢ of the HIS interviewees took the vision screening test in the home and agreed to have the results released, making it possible for the clinic to invite them for an examination. The principal obstacle to the success of the feasibility study was a low rate (< 50 per ¢) of participation in the clinic examination by the target population. Such low participation would leave the survey open to a serious question about its representativeness.  The methods and findings of the pilot study arc presented because the lessons may be of value to those attempting similar studies in the future. Suggestions are made for methodological modifications that may enhance the chances for success. (Am J Public Health 1986; 76:160-165.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VISUAL acuity
KW  - EYE -- Examination
KW  - VISION testing
KW  - VISION disorders
KW  - VISUAL perception
KW  - METROPOLITAN areas -- United States
KW  - UNITED States
KW  - UNITED States. Bureau of the Census
KW  - NATIONAL Center for Health Statistics (U.S.)
N1  - Accession Number: 4685648; Ederer, Fred 1 Krueger, Dean E. 2 Mowery, Richard L. 3 Connett, John 4 Wentworth, Deborah 5; Affiliation:  1: NEI Biometry and Epidemiology Program, Biostatistics Center, George Washington University  2: Research Professor of Statistics and Ophthalmology, Biostatistics Center, George Washington University  3: Health Scientist Administration, Biometry and Epidemiology Program, National Eye Institute, Building 31, room 6A2A, 9000 Rockville Pike, Bethesda, MD 20205  4: Assistant Professor, University of Minnesota Division of Biometry  5: Research Fellow, University of Minnesota Division of Biometry; Source Info: Feb1986, Vol. 76 Issue 2, p160; Subject Term: VISUAL acuity; Subject Term: EYE -- Examination; Subject Term: VISION testing; Subject Term: VISION disorders; Subject Term: VISUAL perception; Subject Term: METROPOLITAN areas -- United States; Subject Term: UNITED States; Company/Entity: UNITED States. Bureau of the Census Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mirsky, Allan F.
AU  - Duncan, Connie C.
T1  - ETIOLOGY AND EXPRESSION OF SCHIZOPHRENIA: Neurobiological and Psychosocial Factors.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1986/02//
VL  - 37
IS  - 1
M3  - Article
SP  - 291
EP  - 319
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Focuses on the etiology and expression of schizophrenia. Neurobiological and psychosocial factors of schizophrenia; Details of multifactorial etiology of schizophrenia; Factors leading to schizophrenia.
KW  - SCHIZOPHRENIA
KW  - DISEASES -- Causes & theories of causation
KW  - NEUROSCIENCES
KW  - NERVOUS system -- Diseases
N1  - Accession Number: 11266074; Mirsky, Allan F. 1 Duncan, Connie C. 1; Affiliation:  1: Laboratory of Psychology and Psychopathology, National  Institute of Mental Health, Bethesda, Maryland 20892.; Source Info: 1986, Vol. 37 Issue 1, p291; Subject Term: SCHIZOPHRENIA; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: NEUROSCIENCES; Subject Term: NERVOUS system -- Diseases; Number of Pages: 29p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Parloff, Morris B.
AU  - London, Perry
AU  - Wolfe, Barry
T1  - INDIVIDUAL PSYCHOTHERAPY AND BEHAVIOR CHANGE.
JO  - Annual Review of Psychology
JF  - Annual Review of Psychology
Y1  - 1986/02//
VL  - 37
IS  - 1
M3  - Article
SP  - 321
EP  - 349
PB  - Annual Reviews Inc.
SN  - 00664308
AB  - Focuses on individual psychotherapy and behavior change. Developments in the field of psychotherapy; Details of meta-analytic study of psychotherapy; list of treatments of specific problems.
KW  - PSYCHOTHERAPY
KW  - CLINICAL sociology
KW  - THERAPEUTICS
KW  - PSYCHIATRY
N1  - Accession Number: 11266080; Parloff, Morris B. 1 London, Perry 2 Wolfe, Barry 3; Affiliation:  1: Department of Psychology, American University, Washington, D.C. 20016.  2: Harvard Graduate School of Education, Harvard University, Cambridge, Massachusetts 02138.  3: Psychosocial Treatments Research Branch, National Institute of Mental Health, Rock-Ville, Maryland 20857.; Source Info: 1986, Vol. 37 Issue 1, p321; Subject Term: PSYCHOTHERAPY; Subject Term: CLINICAL sociology; Subject Term: THERAPEUTICS; Subject Term: PSYCHIATRY; Number of Pages: 29p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Paranjape, R. S.
AU  - Hussain, Rabia
AU  - Nutman, T. B.
AU  - Hamilton, R.
AU  - Ottesen, E. A.
T1  - Identification of circulating parasite antigen in patients with bancroftian filariasis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1986/02//
VL  - 63
IS  - 2
M3  - Article
SP  - 508
EP  - 516
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Because many cases of lymphatic filariasis cannot be diagnosed either clinically or by immunodiagnostic test based on antibody detection, recent efforts have been more directed towards developing methods for detecting parasite antigen in the blood or urine. Using A solid phase (Sepharose 4B) two-site immunoradiometric assay (IRMA) employing hyperimmune rabbit antifilarial antisera, we have previously shown (Hamilton etal; 1984) that essentially all cases of patent (ic. mierofilaremic) infection in patients with bancroftian filariasis can be detected by this semi-quantiialive assay as well as some individuals with amicrofilareirtic (i.e.. 'cryptic') infection. The present communication reports the results of studies that identify a prominent circulating antigen detected by this IRMA in sera from patients with microfilaremia. The antigen was eluted from Sepharose bound rabbit polyelonal antiserum that had been reacted with known antigen positive sera. It was run in SDS-PAGE. blotted to nitrocellulose paper and identified autoradlographically using '-M-Iabelied rabbit antifilarial antiserum. Its high molecular weight ( &tild; 200 kD). stability to acid and boiling, and sensitivity to pronase and periodate suggest its being a glycoprotein. Isolation of this antigen will permit the development of specific reagents (such as monoclonal antibodies) which should enhance both the sensitivity and utility of the currently available antigen detection systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FILARIASIS
KW  - HELMINTHIASIS
KW  - GEL permeation chromatography
KW  - IMMUNOGLOBULINS
KW  - MOLECULAR cloning
KW  - MONOCLONAL antibodies
KW  - filariasis circulating antigen
N1  - Accession Number: 16001793; Paranjape, R. S. Hussain, Rabia 1 Nutman, T. B. Hamilton, R. 2 Ottesen, E. A. 3; Affiliation:  1: Immunology Department, Indian Council of Medical Research-Tuberculosis Research Center, Madras, India.  2: Immunology Division, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA.  3: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Feb1986, Vol. 63 Issue 2, p508; Subject Term: FILARIASIS; Subject Term: HELMINTHIASIS; Subject Term: GEL permeation chromatography; Subject Term: IMMUNOGLOBULINS; Subject Term: MOLECULAR cloning; Subject Term: MONOCLONAL antibodies; Author-Supplied Keyword: filariasis circulating antigen; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gwirtsman, Harry E.
AU  - Yager, Joel
AU  - Gillard, Baiba K.
AU  - Lerner, Linda
T1  - Serum Amylase and Its Isoenzymes in Normal Weight Bulimia.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1986/02//
VL  - 5
IS  - 2
M3  - Article
SP  - 355
EP  - 361
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Bulimia is a relatively common eating disorder with many serious medical complications. In 11 normal weight patients with bulimia, serum amylase isoenzymes were elevated above control values. Both P (pancreatic origin) and S (salivary gland origin) isoenzymes were elevated to approximately equal degrees. These elevations correlated with the time elapsed since the previous meal but did not correlated with any measures of severity of bulimic behavior or clinical estimations of parotid gland enlargement. Saliva amylase was not different from controls. When serum from these patients was sent to the routine clinical chemistry laboratory, total amylase values were reported to be elevated in two patients and near the top of the normal range in an additional patient. Bulimic behavior must be added to the list of conditions that are associated with mild elevations in serum amylase. Serum amylase determination may be useful to clinicians in confirming the diagnosis of bulimia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BULIMIA
KW  - DISEASE complications
KW  - WEIGHT loss
KW  - ISOENZYMES
KW  - PANCREAS
KW  - PAROTID glands
KW  - AMYLASES
KW  - SALIVARY glands
KW  - DIAGNOSIS
KW  - EATING Disorder (Book)
N1  - Accession Number: 12072334; Gwirtsman, Harry E. 1 Yager, Joel 2 Gillard, Baiba K. 3 Lerner, Linda; Affiliation:  1: National Institute of Mental Health  2: Department of psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute  3: Assistant Professor of Medicin, Baylor College of Medicine; Source Info: Feb1986, Vol. 5 Issue 2, p355; Subject Term: BULIMIA; Subject Term: DISEASE complications; Subject Term: WEIGHT loss; Subject Term: ISOENZYMES; Subject Term: PANCREAS; Subject Term: PAROTID glands; Subject Term: AMYLASES; Subject Term: SALIVARY glands; Subject Term: DIAGNOSIS; Reviews & Products: EATING Disorder (Book); Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hawley-Nelson, Pamela
AU  - Berchtold, Martin W.
AU  - Huitfeldt, Henrik
AU  - Spiegel, Jack
AU  - Yuspa, Stuart H.
T1  - Skin Calcium-Binding Protein Is a Parvalbumin of the Panniculus Carnosus.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/02//
VL  - 86
IS  - 2
M3  - Article
SP  - 157
EP  - 162
SN  - 0022202X
AB  - Skin calcium-binding protein (SCaBP) is a calcium binding protein purified from whole rat skin. It has a molecular weight of approximately 12,000 daltons but migrates at Mr 13,000 on sodium dodecyl sulfate (SDS)-polyacrylamide gels. On nitrocellulose blots of SDS-polyacrylamide gels, 6 different antisera to SCaBP reacted equally well with SCaBP and parvalbumin (PV), an 11,500-dalton calcium-binding protein purified from rat skeletal muscle, which also migrates at Mr 13,000 on SDS-polyacrylamide gels. Rabbit antiserum to muscle PV also recognized both PV and SCaBP, and either protein absorbed specific antibodies against either antigen from both types of antisera. Soluble protein extracts from whole adult rat and mouse skin contained a Mr 13,000 protein which was recognized on nitrocellulose blots of SDS gels by both antisera. Blots of extracts from epidermis, dermis, whole skin, and skin scraped on the dermal side to remove hypodermal tissue revealed that the Mr 13,000 PV/SCaBP cross-reacting antigen was restricted to the hypodermal tissue removed by scraping. Immunofluorescent staining of Bouin-fixed skin sections with these antisera confirmed the localization of PV/SCaBP to the panniculus carnosus, a hypodermal muscle layer. Newborn mouse skin does not contain this antigen. Additional polypeptides of Mr 10,500 and 12,000 on SDS gels of extracts from the epidermis of newborn and adult rats and mice were found to be immunoreactive with anti-SCaBp serum. These polypeptides were not recognized by the PV antiserum, and the reactivity of anti-SCaBP for these antigens was not absorbed by purified PV or SCaBP. Our results indicate that SCaBP is antigenically indistinguishable from PV and is localized in the adult rodent panniculus carnosus, and that antisera to SCaBP are poly-specific, recognizing epidermal proteins in addition to SCaBP/PV. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - CALCIUM-binding proteins
KW  - CALCIUM in the body
KW  - CARRIER proteins
KW  - IMMUNOGLOBULINS
KW  - EPITHELIUM
KW  - PEPTIDE hormones
N1  - Accession Number: 12284197; Hawley-Nelson, Pamela 1,2 Berchtold, Martin W. 3 Huitfeldt, Henrik 1 Spiegel, Jack 2 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland.  2: Department of Biology, Catholic University of America, Washington, D.C., U.S.A.  3: Department of Cell Biology, Baylor College of Medicine, Houston, Texas.; Source Info: Feb86, Vol. 86 Issue 2, p157; Subject Term: SKIN; Subject Term: CALCIUM-binding proteins; Subject Term: CALCIUM in the body; Subject Term: CARRIER proteins; Subject Term: IMMUNOGLOBULINS; Subject Term: EPITHELIUM; Subject Term: PEPTIDE hormones; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12284197
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06433-054
AN  - 2006-06433-054
AU  - Hommer, Daniel W.
T1  - Hypnotics: Their Effects by Night and by Day.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1986/02//
VL  - 31
IS  - 2
SP  - 148
EP  - 149
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06433-054. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hommer, Daniel W.; Electrophysiolog Unit, Clinical Neuroscience Research Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Benzodiazepines; Cognitive Processes; Hypnotic Drugs; Sleep. Minor Descriptor: Memory. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Hindmarch, I. (Ed); Ott, H. (Ed); Roth, T. (Ed). Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects. Psychopharmacology Supplementum 1=Berlin, Federal Republic of Germany: Springer-Verlag Berlin, 1984. 231 pp. $36.50; 1984. Page Count: 2. Issue Publication Date: Feb, 1986. 
AB  - Reviews the book, Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects. Psychopharmacology Supplementum 1 edited by I. Hindmarch, H. Ott, and T. Roth (1984). The papers represent a variety of approaches to examining the effects of benzodiazepine hypnotics both on sleep itself and on a variety of measures of daytime performance. The overall quality of the writing and editing is quite good, and the editors have provided an extremely useful author and subject index. One disappointing aspect of this monograph is the relatively small amount of attention paid to the effects of benzodiazepines on memory. The relationship between sedation and memory is important for the clinical use of these drugs as well as for the cognitive sciences in general, it is unfortunate that this topic was not more extensively explored. Despite this shortcoming, this book provides a good summary of the current state of research regarding benzodiazepines, sleep, and performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - benzodiazepine hypnotics
KW  - sleep
KW  - daytime performance
KW  - memory
KW  - 1986
KW  - Benzodiazepines
KW  - Cognitive Processes
KW  - Hypnotic Drugs
KW  - Sleep
KW  - Memory
KW  - 1986
U2  - Hindmarch, I. (Ed); Ott, H. (Ed); Roth, T. (Ed). (1984); Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects. Psychopharmacology Supplementum 1; Berlin, Federal Republic of Germany: Springer-Verlag Berlin, 1984. 231 pp. $36.50
DO  - 10.1037/024531
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Masataka, Nobuo
AU  - Symmes, David
T1  - Effect of Separation Distance on Isolation Call Structure in Squirrel Monkeys (Saimiri sciureus).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1986/03//
VL  - 10
IS  - 3
M3  - Article
SP  - 271
EP  - 278
SN  - 02752565
AB  - Isolation calls of captive squirrel monkeys were recorded by separating infants from their natal group members and then permitting vocal contact between the "lost" baby and the group at systematically varied distances. Separated infants gave longer calls at greater separation distances from their natal group members, and responding adults and juveniles similarly extended the length of their vocalizations. In the longer variants, a high- frequency element was prolonged, which is considered to be an example of the net advantage of a "frequency window" in the ambient noise of environments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUIRREL monkeys
KW  - INFANTS
KW  - ANIMAL behavior
KW  - COMMUNICATION
KW  - PRIMATES
KW  - communication.
KW  - infant separation
KW  - Saimiri sciureus
KW  - squirrel monkeys
KW  - vocalizations
N1  - Accession Number: 12371878; Masataka, Nobuo 1 Symmes, David 1; Affiliation:  1: Luboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1986, Vol. 10 Issue 3, p271; Subject Term: SQUIRREL monkeys; Subject Term: INFANTS; Subject Term: ANIMAL behavior; Subject Term: COMMUNICATION; Subject Term: PRIMATES; Author-Supplied Keyword: communication.; Author-Supplied Keyword: infant separation; Author-Supplied Keyword: Saimiri sciureus; Author-Supplied Keyword: squirrel monkeys; Author-Supplied Keyword: vocalizations; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaye, Walter H.
AU  - Gwirtsman, Harry
AU  - George, Ted
AU  - Ebert, Michael H.
AU  - Petersen, Rosemary
T1  - Caloric Consumption and Activity Levels After Weight Recovery in Anorexia Nervosa: A Prolonged Delay in Normalization.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1986/03//
VL  - 5
IS  - 3
M3  - Article
SP  - 489
EP  - 502
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - In the 2 to 6 weeks after completion of refeeding and termination of a weight restoration program, patients with anorexia nervosa required greater than normal caloric intake to maintain a stable weight and had elevated levels of activity. By contrast, such patients studied 6 months or longer after weight recovery had normal caloric intake and activity levels. The prolonged delay in normalization of caloric intake and activity is mirrored by the slow resolution to normal of the neuroendocrine dysregulation that characterizes this disorder. This suggests that treatment for weight maintenance in anorexia nervosa should be extended aggressively for months after the return of a healthy weight so as to restore normal neuroendocrine function and thereby enhance the likelihood of permanent recovery. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FOOD -- Caloric content
KW  - ANOREXIA nervosa
KW  - WEIGHT gain
KW  - NEUROENDOCRINOLOGY
KW  - WEIGHT loss -- Endocrine aspects
KW  - WEIGHT loss
N1  - Accession Number: 12064199; Kaye, Walter H. 1 Gwirtsman, Harry 2 George, Ted 2 Ebert, Michael H. 3 Petersen, Rosemary 4; Affiliation:  1: Staff Psychiatrist, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland.  2: Clinical Associates,Laboratory of Clinical Science.  3: Chairman, Department of Psychiatry,Vanderbilt University, Nashville Tennessee.  4: Clinical Nutritionist, Nutrition Department, Clinical Center NIH.; Source Info: Mar1986, Vol. 5 Issue 3, p489; Subject Term: FOOD -- Caloric content; Subject Term: ANOREXIA nervosa; Subject Term: WEIGHT gain; Subject Term: NEUROENDOCRINOLOGY; Subject Term: WEIGHT loss -- Endocrine aspects; Subject Term: WEIGHT loss; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Breathnach, Stephen M.
AU  - Shimada, Shinji
AU  - Kovac, Zdenko
AU  - Katz, Stephen I.
T1  - Immunologic Aspects of Acute Cutaneous Graft-Versus-Host Disease: Decreased Density and Antigen-Presenting Function of Ia+ Langerhans Cells and Absent Antigen-Presenting Capacity of Ia+ Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/03//
VL  - 86
IS  - 3
M3  - Article
SP  - 226
EP  - 234
SN  - 0022202X
AB  - Cutaneous graft-versus-host disease (GVHD) provides a unique model for studying the pathogenesis of several important lymphocyte-mediated skin diseases. Morphologic studies have suggested that Ia antigen (Ia)-bearing epidermal Langerhans cells (LC) may be specific targets for destruction in these conditions. Keratinocytes synthesize and express Ia in GVHD and some other lymphocyte-mediated skin disorders; Ia+ keratinocytes, constitutively able to secrete epidermal cell-derived thymocyte activating factor (ETAF)/interleukin 1, may possess antigen-presenting capacity, thus leading to enhanced cutaneous immune responses and disease chronicity. We therefore investigated the fate of Ia+ LC, and the potential antigen-presenting capacity of Ia+ keratinocytes, in a murine model of GVHD. Lethally irradiated C3H/He (H-2k) mice developed acute cutaneous GVHD, and expressed keratinocyte Iak, 8 days after injection of BALB/c (H-2d) bone marrow and spleen cells. Immunofluorescence studies showed a progressive decrease in the density of Ia+ epidermal LC during the evolution of GVHD. This decrease was paralleled by a progressive reduction in the allostimulatory capacity of GVHD epidermal cells (EC) in the allogeneic EC-lymphocyte reaction (ELR). The fall in the density of Ia+ LC, and in EC allostimulatory capacity in both primary and secondary ELRs, was consistently greater in GVHD mice than in mice treated only with x-irradiation. The allostimulatory capacity of GVHD and x-irradiated EC could not be restored by addition of indomethacin or exogenous ETAF to ELR cultures. The decreased allostimulatory capacity was not the result of inhibition of the ELR, since EC from GVHD and x-irradiated mice did not cause suppression when added to control ELR cultures. The Capacity of EC to present ovalbumin, purified protein derivative of tuberculin, 2,4,6-trinitrobenzynesulfonic acid coupled to EC, and native cytochrome <em>c</em> (CYTc) to antigen-specific T-cell lines, clones, or hybridomas was reduced in x-irradiated mice and markedly decreased in GVHD mice. The capacity of EC from x-irradiated and GVHD mice to present CYTc fragment 81-104, which does not require further processing or catabolism by accessory cells, was similarly decreased. Taken together, the results indicate that: (1) the function of LC is markedly and progressively impaired in acute GVHD; (2) LC function is also decreased, but to a lesser extent, following x-irradiation alone; and (3) Ia + keratinocytes from lethally irradiated mice undergoing GVHD do not exhibit antigen-presenting capacity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GRAFT versus host disease
KW  - LYMPHOCYTES
KW  - SKIN diseases
KW  - ANTIGENS
KW  - LANGERHANS cells
KW  - IA antigens
KW  - KERATINOCYTES
N1  - Accession Number: 12285176; Breathnach, Stephen M. 1 Shimada, Shinji 2 Kovac, Zdenko 3 Katz, Stephen I. 2; Affiliation:  1: Department of Medicine (Dermatology), Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, U.K.  2: Dermatology Branch, National Cancer Institute, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: University of Zagreb, Zagreb, Croatia, Yugoslavia.; Source Info: Mar1986, Vol. 86 Issue 3, p226; Subject Term: GRAFT versus host disease; Subject Term: LYMPHOCYTES; Subject Term: SKIN diseases; Subject Term: ANTIGENS; Subject Term: LANGERHANS cells; Subject Term: IA antigens; Subject Term: KERATINOCYTES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1523-1747.ep12285176
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Maibach, Edward
AU  - Gigliotti, Lillian
AU  - Block, Gladys
T1  - REPORT ON THE POST'S CANCER PREVENTION SURVEY.
JO  - Saturday Evening Post
JF  - Saturday Evening Post
Y1  - 1986/03//
VL  - 258
IS  - 2
M3  - Article
SP  - 66
EP  - 112
PB  - Saturday Evening Post Society, Inc..
SN  - 00489239
AB  - Presents the results of a survey on cancer prevention in the U.S.  Reasons for not having regular mammographic examinations; Way to reduce the cost of the examination; Purpose of mammography; Association between diet and cancer; Effect of smoking.
KW  - CANCER prevention
KW  - SURVEYS
KW  - MAMMOGRAMS
KW  - UNITED States
N1  - Accession Number: 11649378; Maibach, Edward 1 Gigliotti, Lillian Block, Gladys; Affiliation:  1: National Cancer Institute; Source Info: Mar86, Vol. 258 Issue 2, p66; Subject Term: CANCER prevention; Subject Term: SURVEYS; Subject Term: MAMMOGRAMS; Subject Term: UNITED States; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaufmann, Nathan A.
AU  - Dennis, Barbara H.
AU  - Heiss, Gerardo
AU  - Friedlander, Yehiel
AU  - Kark, Jeremy D.
AU  - Stein, Yechezkiel
T1  - Comparison of nutrient intakes of selected populations in the United States and Israel: the lipid research clinics prevalence study.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/04//
VL  - 43
IS  - 4
M3  - Article
SP  - 604
EP  - 620
SN  - 00029165
AB  - Nutrient intakes of 2,772 US and 2,680 Jerusalem participants of the Lipid Research Clinics Program were assessed by 24-h dietary recall in men aged 15-19 and 40-59 yr and women aged 15-19 and 35-59 yr. Energy intake was higher in the US than in Jerusalem. In Jerusalem intake of total fat ranged between 32.2-33.7% of kcal, of saturated fatty acids (SFA) between 9.8-10.9%, of polyunsaturated fatty acids (PFA) between 7.9-8.6%, of carbohydrates between 50.5-53.9%, and of starch between 24.0-30.5%. The P:S ratio ranged between 0.80 and 1.01. The corresponding ranges for the US were 38.8-40.8% for fat, 14.3-15.9% for SFA, 5.9-6.8% for PFA, 38.9-46.2% for carbohydrates, 17.0-17.9% for starch, and 0.40-0.53 for the P:S ratio. Intake of cholesterol (mg/1000 kcal) was higher in Jerusalem than in the US. These data address the feasibility of reducing fat in diets of free-living, Western populations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Saturated fatty acids
KW  - Carbohydrates
KW  - Jerusalem
KW  - United States
KW  - Israel
KW  - dietary carbohydrates
KW  - dietary cholesterol
KW  - dietary fats
KW  - Nutrition survey
N1  - Accession Number: 91096106; Kaufmann, Nathan A. 1; Dennis, Barbara H. 2; Heiss, Gerardo 3; Friedlander, Yehiel 4; Kark, Jeremy D. 5; Stein, Yechezkiel 4; Affiliations: 1: Department of Nutrition, Hebrew University--Hadassah Medical School, Jerusalem, Israel; 2: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; 3: Lipid Research Clinics Program and Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC; 4: Jerusalem Lipid Research Clinic, Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel; 5: Department of Social Medicine, Hebrew University--Hadassah School of Public Health and Community Medicine, Jerusalem, Israel; Issue Info: Apr1986, Vol. 43 Issue 4, p604; Subject Term: Saturated fatty acids; Subject Term: Carbohydrates; Subject: Jerusalem; Subject: United States; Subject: Israel; Author-Supplied Keyword: dietary carbohydrates; Author-Supplied Keyword: dietary cholesterol; Author-Supplied Keyword: dietary fats; Author-Supplied Keyword: Nutrition survey; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - La Vecchia, Carlo
AU  - Decarli, Adriano
T1  - Trends in Ischemic Heart Disease Mortality in Italy, 1968-78.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/04//
VL  - 76
IS  - 4
M3  - Article
SP  - 454
EP  - 456
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: In Italy during the period 1968-78, female heart disease mortality decreased in all age groups up to age 79, with an average annual rate of decline in the 35-74 age-standardized rate of over 0.7 per ¢. In males, age-specific death rates in some age groups were stable or increased moderately, but in middle-aged (50 to 59) males there was a consistent increase so that the rise in the 35-74 age standardized male death rate was approximately 1 per ¢ per year. (Am J Public Health 1986; 76:454-456.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORONARY heart disease
KW  - MORTALITY -- Statistics
KW  - HEART diseases in women
KW  - MALES
KW  - AGE groups
KW  - DEATH
KW  - HEART diseases
KW  - PUBLIC health
KW  - ITALY
N1  - Accession Number: 4686467; La Vecchia, Carlo 1 Decarli, Adriano 2; Affiliation:  1: Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy.  2: Institute of Medical Statistics, University of Milan and National Cancer Institute, Milan.; Source Info: Apr1986, Vol. 76 Issue 4, p454; Subject Term: CORONARY heart disease; Subject Term: MORTALITY -- Statistics; Subject Term: HEART diseases in women; Subject Term: MALES; Subject Term: AGE groups; Subject Term: DEATH; Subject Term: HEART diseases; Subject Term: PUBLIC health; Subject Term: ITALY; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Goldman, Howard H.
AU  - Morrtssey, Joseph P.
T1  - Response from Drs. Goldman and Morrissey.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/04//
VL  - 76
IS  - 4
M3  - Letter
SP  - 464
EP  - 464
PB  - American Public Health Association
SN  - 00900036
AB  - A response by Howard H. Goldman and Joseph P. Morrissey to a letter to the editor about their article on the policy of community mental health centers is presented.
KW  - LETTERS to the editor
KW  - MENTAL health policy
N1  - Accession Number: 22478436; Goldman, Howard H. 1 Morrtssey, Joseph P. 2; Affiliation:  1: Assistant Director, National Institute of Mental Health, Rockville, MD  2: Senior Research Sociologist, Office of Mental Health, New York State, Albany; Source Info: Apr1986, Vol. 76 Issue 4, p464; Subject Term: LETTERS to the editor; Subject Term: MENTAL health policy; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 1/4p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bender, B. S.
AU  - Auger, F. A.
AU  - Quinn, T. C.
AU  - Redfield, R.
AU  - Gold, J.
AU  - T. M. Folks
T1  - Impaired antibody-dependent cell-mediated cytotoxic activity in patients with the acquired immunodeficiency syndrome.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1986/04//
VL  - 64
IS  - 1
M3  - Article
SP  - 166
EP  - 172
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Since the acquired immunodeficiency syndrome (AIDS) is characterized by opportunistic infections and malignancies indicative of a profound suppression in cell-mediated immunity, we investigated the antibody-dependent cell-mediated cytotoxicity (ADCC) of peripheral blood mononuclear cells of patients with AIDS against chicken red blood cells (CRBC). A marked decrease in ADCC-CRBC activity was observed from patients with AIDS as compared lo healthy controls. Furthermore, suppression in ADCC activity was seen when mononuclear cells from healthy subjects were assayed using media containing 25% or 40% sera from AIDS patients. Two of two patients with AIDS and impaired ADCC-CRBC activity were also found to have in vivo impaired reticuloendothelial system Fc-specific clearance of 15Cr-labelled, anti-Rho (D) IgG-sensitized autologous erythrocytes. These data provide further evidence of monocyte-macrophage dysfunction in AIDS and help explain the widespread occurrence of opportunistic pathogens in AIDS. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL-mediated cytotoxicity
KW  - AIDS patients
KW  - INFECTION
KW  - BLOOD cells
KW  - KILLER cells
KW  - BLOOD plasma
KW  - CELLULAR immunity
KW  - AIDS
KW  - antibody-dependent cell-mediated cytotoxicity
KW  - monocytes
N1  - Accession Number: 16178729; Bender, B. S. 1,2 Auger, F. A. 3 Quinn, T. C. 2,4 Redfield, R. 5 Gold, J. 6 T. M. Folks 3; Affiliation:  1: Clinical Immunology Section, National Institute on Aging, NIH.  2: Division of Infectious Diseases, Johns Hopkins Hospital.  3: Office of  Scientific Director, National Institute of Allergy and Infectious Disease, NIH.  4: Laboratory of Clinical Investigation, National Institute of Allergy and Infections Disease, NIH.  5: Walter Reed Army Medical Research Institute .  6: Division of Infectious Diseases, Memorial Sloan Kettering Hospital, USA.; Source Info: Apr1986, Vol. 64 Issue 1, p166; Subject Term: CELL-mediated cytotoxicity; Subject Term: AIDS patients; Subject Term: INFECTION; Subject Term: BLOOD cells; Subject Term: KILLER cells; Subject Term: BLOOD plasma; Subject Term: CELLULAR immunity; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: antibody-dependent cell-mediated cytotoxicity; Author-Supplied Keyword: monocytes; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rozenszajn, L. A.
AU  - Muellenberg-Coulombre, C.
AU  - Gery, I.
AU  - El-Saied, M.
AU  - Kuwabara, T.
AU  - Mochizuki, M.
AU  - Lando, Z.
AU  - Nussenblatt, R. B.
T1  - Induction of experimental autoimmune uveoretinitis by T-cell lines.
JO  - Immunology
JF  - Immunology
Y1  - 1986/04//
VL  - 57
IS  - 4
M3  - Article
SP  - 559
EP  - 565
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Experimental autoimmune uveoretinitis was induced in genetically susceptible Lewis rats by passive transfer of T-lymphocyte cell lines from long-term cultures primed against soluble retinal antigen (S- Ag). A continuous T-cell line was established from non-adherent lymph node cells of S-Ag- immunized Lewis rats. The lymphoid cells were propagated in vitro by serially restimulating them with S-Ag in the presence of irradiated syngeneic spleen cells and expanding them in IL-2-containing media. The cell lines exhibited markers specific for T lymphocytes and the majority had the helper phenotype. When naive rats were inoculated intravenously with anti S-Ag T-cell lines re-exposed to the antigen prior to injection, they developed uveoretinitis with both clinical and histological characteristics in half the time required by S-Ag to induce the disease by active immunization. The rats exhibited a delayed hypersensitivity skin reaction towards S-Ag. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOIMMUNE diseases
KW  - T cells
KW  - LYMPHOCYTES
KW  - CELL lines
KW  - RATS
KW  - CELL culture
N1  - Accession Number: 14005228; Rozenszajn, L. A. 1 Muellenberg-Coulombre, C. 2 Gery, I. 2 El-Saied, M. 2 Kuwabara, T. 2 Mochizuki, M. 2 Lando, Z. 2 Nussenblatt, R. B. 2; Affiliation:  1: National Eye Institute, Clinical Branch and the Laboratory of Vision Research, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland, U.S.A.  2: Department of Life Sciences, Bar-Han University, Ramat-Gran, 52100 Israel.; Source Info: Apr86, Vol. 57 Issue 4, p559; Subject Term: AUTOIMMUNE diseases; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: CELL lines; Subject Term: RATS; Subject Term: CELL culture; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cooper, Kevin D.
AU  - Neises, Gabrielle R.
AU  - Katz, Stephen I.
T1  - Antigen-Presenting OKM5+ Melanophages Appear in Human Epidermis After Ultraviolet Radiation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/04//
VL  - 86
IS  - 4
M3  - Article
SP  - 363
EP  - 370
SN  - 0022202X
AB  - Ultraviolet radiation of murine skin in vivo or epidermal cells (EC) in vitro dramatically inhibits the antigen-presenting capacity of EC in vitro and results in the inhibition of immune responses to antigen challenge. In humans, UV exposure in vivo markedly inhibits alloantigen presentation by EC in the EC-lymphocyte reaction (ELR) when EC arc harvested immediately after the administration of 4 times the minimal erythema dose (4 MED), whereas EC harvested 72 h after 4 MED (UV-EC) exhibit enhanced allostimulatory capacity in the ELR. This enhanced ELR reactivity is due to the appearance, in the epidermis, of bone marrow-derived OKT6- DR+ cells which are distinct from Langerhans cells (LC) in their lack of surface OKT6 and in their ultrastructural morphology. This report focuses on the phenotype and function of T6- Dr+ UV-EC and on their relationship to known human antigen presenting cell (APC) subsets. Approximately 60% of T6- Dr+ UV-EC bore the monocyte marker defined by monoclonal antibody OKM5, but lacked determinants recognized by OKM1, LeuM1, LeuM3, LeuM4, LeuM5, and Mac1. All T6- Dr+ UV-EC bore the class II MHC antigen HLA-DQ (DC/DS), which is associated with a specialized subset of antigen-presenting monocytes capable of stimulation in the autologous mixed leukocyte reaction (AMLR). Panning of OKM5+ UV-EC resulted in a population of cells which was markedly enriched in melanophages and which exhibited potent alloantigen-presenting capacity in the ELR. Since OKM5+ T6- Dr+ UV- EC were similar to the specialized APC minor subset of OKM1- OKM5+ blood monocytes both in phenotype and in apparent phagocytic function, we examined other APC functions of UV-EC to assess the extent of this analogy. Relative to control of EC (containing only LC as APC), UV-EC (containing functionally inactivated LC but many T6-Dr+ APC) induced significantly greater degrees of T-cell proliferation in the presence of either tetanus toxoid antigen or the mitogen concanavalin A, UV-EC, as well as panning-purified OKM5+ UV-EC, were also able to induce autologous T-cell proliferation in the absence of added antigen (autologous ERL) in contrast to control EC which were poor stimulators of an autologous ELR. Thus, although human EC 72 h after UV exposure are numerically and functionally depleted of LC, at least 2 additional subsets of T6- Dr+ APC appear in the epidermis. One of these subsets is OKMI-OKM5- DQ+. The major subset is OKMI-OKM5- DQ+ and appears phenotypically and functionally analogus to the highly specialized OKM1- OKM5+ subset of blood monocytes capable of phagocytosis, soluble antigen presentaiton, and stimulation in the AMLR. These non-LC APC subsets may be involved in altered APC-T cell actiation mechanisms when skin is irradiated with UV in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRAVIOLET radiation
KW  - IMMUNE response
KW  - ANTIGENS
KW  - ERYTHEMA
KW  - MONOCYTES
KW  - PHENOTYPE
KW  - BONE marrow
N1  - Accession Number: 12285600; Cooper, Kevin D. 1 Neises, Gabrielle R. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr86, Vol. 86 Issue 4, p363; Subject Term: ULTRAVIOLET radiation; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: ERYTHEMA; Subject Term: MONOCYTES; Subject Term: PHENOTYPE; Subject Term: BONE marrow; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12285600
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Woodley, David T.
AU  - Kalebec, Tea
AU  - Banes, Albert J.
AU  - Link, William
AU  - Prunieras, Michel
AU  - Liotta, Lance
T1  - Adult Human Keratinocytes Migrating over Nonviable Dermal Collagen Produce Collagenolytic Enzymes That Degrade Type I and Type IV Collagen.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/04//
VL  - 86
IS  - 4
M3  - Article
SP  - 418
EP  - 423
SN  - 0022202X
AB  - Human adult keratinocytes migrating on a nonviable dermal substrate in cultures without fibroblasts induce thinning and degradation of the collagen substrate beneath the migrating epithelium. Further, unconcentrated conditioned medium from the cultures exhibit collagenolytic activity against both type I and type IV collagen which is inhibited by EDTA but not by phenylmethylsulfonyl fluoride or N-ethylmaleimide. Since the migrating epithelium and dermal substrate do not contain fibroblasts, this study shows that migratory keratinocytes in contact with interstitial collagen are capable of producing collagenases against type I and type IV collagen. Moreover, migratory keratinocytes appear to be similar to highly metastatic cells in their ability to degrade basement membrane collagen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - FIBROBLASTS
KW  - COLLAGEN
KW  - EPITHELIUM
KW  - ETHYLENEDIAMINETETRAACETIC acid
KW  - CELLS
N1  - Accession Number: 12285689; Woodley, David T. 1 Kalebec, Tea 2 Banes, Albert J. 3 Link, William 3 Prunieras, Michel 4 Liotta, Lance 2; Affiliation:  1: Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.  2: Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.  4: Department of Cell Biology, Center for International Dermatologic Research, Valbonne, France.; Source Info: Apr86, Vol. 86 Issue 4, p418; Subject Term: KERATINOCYTES; Subject Term: FIBROBLASTS; Subject Term: COLLAGEN; Subject Term: EPITHELIUM; Subject Term: ETHYLENEDIAMINETETRAACETIC acid; Subject Term: CELLS; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12285689
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GILDEN, RAYMOND V.
AU  - GONDA, MATTHEW A.
AU  - SARNGADHARAN, M. G.
AU  - POPOVIC, MIKULAS
AU  - GALLO, ROBERT C.
T1  - HTLV-III Legend Correction.
JO  - Science
JF  - Science
Y1  - 1986/04/18/
VL  - 232
IS  - 4748
M3  - Article
SP  - 307
EP  - 307
SN  - 00368075
N1  - Accession Number: 87436691; GILDEN, RAYMOND V. 1 GONDA, MATTHEW A. 1 SARNGADHARAN, M. G. 2 POPOVIC, MIKULAS 3 GALLO, ROBERT C. 3; Affiliation:  1: Program Resources, NCI-Frederick Cancer Research Facility, Frederick, AMD 21701  2: Department of Cell Biology, Biohetics, Inc., Kensington, MD 20895  3: Laboratory ofTumor Cell Bwlogy, National Cancer Institute, Bethesda, AM 20892; Source Info: 4/18/1986, Vol. 232 Issue 4748, p307; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wayne, Robert K.
T1  - Origins of the Domestic Dog: The Fossil Record (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1986/05//May/Jun86
VL  - 74
IS  - 3
M3  - Book Review
SP  - 316
EP  - 317
SN  - 00030996
AB  - Reviews the book 'Origins of the Domestic Dog: The Fossil Record,' by Stanley J. Olsen.
KW  - Dogs
KW  - Nonfiction
KW  - Olsen, Stanely J.
KW  - Origins of the Domestic Dog (Book)
N1  - Accession Number: 11232722; Wayne, Robert K. 1; Affiliations: 1: National Cancer Institute; Issue Info: May/Jun86, Vol. 74 Issue 3, p316; Thesaurus Term: Dogs; Subject Term: Nonfiction; Reviews & Products: Origins of the Domestic Dog (Book); NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; People: Olsen, Stanely J.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Gerstenblith, Gary
AU  - Lakatta, Edward G.
T1  - Geriatric hypertension: Aggressive therapy and its physiologic rationale.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1986/05//
VL  - 41
IS  - 5
M3  - Article
SP  - 44
EP  - 53
SN  - 0016867X
N1  - Accession Number: 17333536; Gerstenblith, Gary 1; Lakatta, Edward G. 2,3,4; Source Information: May1986, Vol. 41 Issue 5, p44; Number of Pages: 8p; Illustrations: 6 Graphs; Document Type: Article; Full Text Word Count: 4317
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Furuichi, K.
AU  - Ra, C.
AU  - Isersky, C.
AU  - Rivera, J.
T1  - Comparative evaluation of the effect of pharmacological agents on endocytosis and coendocytosis of IgE by rat basophilic leukaemia cells.
JO  - Immunology
JF  - Immunology
Y1  - 1986/05//
VL  - 58
IS  - 1
M3  - Article
SP  - 105
EP  - 110
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The aggregation of IgE bound to rat basophilic leukaemia (RBL) cells leads to the exocytosis of mediators, the endocytosis of the antigen-aggregated mouse IgE anti-DNP, as well as the coendocytosis of some unaggregated monomeric rat IgE (IR162) and/or unbound receptors. We describe here the relative effect on endocytosis and coendocytosis of various pharmacological agents that block or enhance exocytosis. We have previously shown that, unlike exocytosis, endocytosis by RBL and normal rat mast cells was independent of extracellular calcium. We show here that the presence of calcium chelators or antagonists also had no effect on endocytosis of cross-linked IgE. However, coendocytosis of non-cross-linked IgE was partially inhibited by the elimination of extracellular calcium and the addition of calcium chelators such as EDTA or EGTA-Mg2+. Moreover, the addition of calcium antagonists such as Ni2+ and Co2+ (5 mM) to an incubation mixture containing Ca2+ (1 mM) resulted in the complete inhibition of coendocytosis without affecting endocytosis. Other inhibitors of exocytosis such as sodium azide (10-2 M), quercetin (10-2 M) and dibutyryl cyclic AMP (10-2 M) blocked coendocytosis completely but had no effect on endocytosis. Sodium azide (10 mM) in combination with 2-deoxyglucose (10 mM) effectively inhibited (90%) endocytosis. Cytochalasin B (10-4 M), which was shown to enhance serotonin release, had no effect on the extent of endocytosis or coendocytosis observed 20 min after the initiation of aggregation. Thus, in RBL cells, endocytosis, coendocytosis and exocytosis exhibit distinguishable sensitivities to some pharmacological drugs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDOCYTOSIS
KW  - BASOPHILS
KW  - LEUKEMIA
KW  - RATS as laboratory animals
KW  - MAST cells
KW  - EXOCYTOSIS
N1  - Accession Number: 14004897; Furuichi, K. 1 Ra, C. 1 Isersky, C. 1 Rivera, J. 1; Affiliation:  1: Section on Chemical Immunology, Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May86, Vol. 58 Issue 1, p105; Subject Term: ENDOCYTOSIS; Subject Term: BASOPHILS; Subject Term: LEUKEMIA; Subject Term: RATS as laboratory animals; Subject Term: MAST cells; Subject Term: EXOCYTOSIS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Löe, H.
AU  - Anerud, A.
AU  - Boysen, H.
AU  - Morrison, E.
T1  - Natural history of periodontal disease in man: Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age.
T2  - Der natürliche Verlauf der menschlichen Parodontalkrankheit Rapider, mässiger und kein Attachmentverlust bei Arbeirern im Alter von 14 46 Jahren in Sri Lanka.
T2  - Histoire naturelle de la maladie parodontale chez l'hamme. Perte d'attache rapide, modérée ou absente chez des travailleurs sri lankais âgés de 14 à 46 ans.
JO  - Journal of Clinical Periodontology
JF  - Journal of Clinical Periodontology
Y1  - 1986/05//
VL  - 13
IS  - 5
M3  - Article
SP  - 431
EP  - 440
SN  - 03036979
AB  - This paper describes the initiation, rate of progress of periodontal disease and consequent tooth loss in a population never exposed to any programs or incidents relative to prevention and treatment of dental diseases. The group consisted of 480 male laborers at two tea plantations in Sri Lanka. The study design and baseline data have been published. At the initial examination in 1970, the age of the participants ranged between 14 and 31 years. Subsequent examinations occurred in 1971, 1973, 1977, 1982 and 1985. Thus, the study covers the age range 14 46 years. Throughout the study, the clinical indices were scored by the same two examiners, both well-trained and experienced periodontitis. Intra-examiner reproducibility for each index was tested at baseline and repeated periodically during the study. The data for each examination were computerized and updated on an ongoing basis. At the last examination in 1985, there were 161 individuals who had participated in the first survey. This population did not perform any conventional oral hygiene measures and consequently displayed quite uniformly large aggregates of plaque, calculus and stain on their teeth. Virtually all gingival units exhibited inflammation. Based on interproximal loss of attachment and tooth mortality rates, three subpopulations were identified: (1) individuals (∼ 8%) with rapid progression of periodontal disease (RP), those (∼ 81 %) with moderate progression (MP), and a group (∼ 11 %) who exhibited no progression (NP) of periodontal disease beyond gingivitis. At 35 years of age, the mean loss of attachment in the RP group was ∼ 9 mm, the MP group had ∼ 4 mm and the NP group had less than 1 mm loss of attachment. At the age of 45 years, the mean loss of attachment in the RP group was ∼ 13 mm and the MP group ∼ 7 mm. The annual rate of destruction in the BY group varied between 0.1 and 1.0 mm, in the MP group between 0.05 and 0.5 mm, and in the NP group between 0.05 and 0.09 mm. Since this population was virtually caries free, essentially all missing teeth were lost due to periodontal disease. In the RP group, tooth loss already occurred at 20 years of age and increased throughout the next 25 years. At 35 years of age, 12 teeth had been lost, at 40 years of age 20 teeth were missing and at 45 all teeth were lost. In the MP groups, tooth mortality started after 30 years of age and increased throughout the decade. At 45 years of age, the mean loss of teeth in this group was 7 teeth. The NP group essentially showed no tooth loss. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical Periodontology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERIODONTAL disease
KW  - TOOTH loss
KW  - PERIODONTITIS
KW  - GINGIVITIS
KW  - CLINICAL trials
KW  - ORAL hygiene
KW  - loss of attachment
KW  - moth loss.
KW  - Natural history
KW  - periodontal disease
N1  - Accession Number: 13602740; Löe, H. 1 Anerud, A. 1 Boysen, H. 1 Morrison, E. 1; Affiliation:  1: National Institute of Dental Research, National Institutes of Health, Bethesda Maryland, USA; Source Info: May1986, Vol. 13 Issue 5, p431; Subject Term: PERIODONTAL disease; Subject Term: TOOTH loss; Subject Term: PERIODONTITIS; Subject Term: GINGIVITIS; Subject Term: CLINICAL trials; Subject Term: ORAL hygiene; Author-Supplied Keyword: loss of attachment; Author-Supplied Keyword: moth loss.; Author-Supplied Keyword: Natural history; Author-Supplied Keyword: periodontal disease; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1600-051X.ep13602740
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morrison, Edith C.
AU  - Kowalski, Charles J.
T1  - Discussion: Clinical measurements of periodontitis.
JO  - Journal of Clinical Periodontology
JF  - Journal of Clinical Periodontology
Y1  - 1986/05//
VL  - 13
IS  - 5
M3  - Article
SP  - 456
EP  - 458
SN  - 03036979
AB  - The article comments on the use of sequential linear regression (SLR) analysis to monitor patients with periodontal disease. The model is at least relatively realistic and that its attendant assumptions are satisfied. If one believes in the random burst hypothesis, choosing the SLR model is choosing a model believed to be inappropriate. Indeed, the SLR model would be the model of choice only if one believed that periodontal disease was a continuous, progressive process. The SLR model is logically inconsistent with the random burst hypothesis.
KW  - PERIODONTAL disease
KW  - REGRESSION analysis
KW  - STATISTICS
KW  - RANDOM variables
KW  - CORRELATION (Statistics)
KW  - PERIODONTITIS
N1  - Accession Number: 13602781; Morrison, Edith C. 1 Kowalski, Charles J. 2; Affiliation:  1: National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, USA  2: Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Source Info: May1986, Vol. 13 Issue 5, p456; Subject Term: PERIODONTAL disease; Subject Term: REGRESSION analysis; Subject Term: STATISTICS; Subject Term: RANDOM variables; Subject Term: CORRELATION (Statistics); Subject Term: PERIODONTITIS; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1600-051X.ep13602781
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Carlos, James P.
T1  - Summary and looking to the future.
JO  - Journal of Clinical Periodontology
JF  - Journal of Clinical Periodontology
Y1  - 1986/05//
VL  - 13
IS  - 5
M3  - Article
SP  - 547
EP  - 548
SN  - 03036979
AB  - The article presents a brief summary of a conference on Clinical Trials in Periodontal Disease. The existing epidemiological data on gingivitis, presents a totally confusing and really a virtually useless body of information. It was stated that there are a number of indices available and in use to measure gingivitis, all of which, or none of which are satisfactory, depending upon one's point of view. A particularly significant issue, which arose, was the discussion of the perils of using a so-called active control without placebo in these trials. It was pointed out that to do so requires a strong faith in the idea that the results of earlier trials will always recur; that an agent once shown to be effective will continue to be effective in all future circumstances.
KW  - PERIODONTAL disease
KW  - CLINICAL trials
KW  - EPIDEMIOLOGY
KW  - GINGIVITIS
KW  - INDEXES
KW  - ORAL hygiene
N1  - Accession Number: 13603798; Carlos, James P. 1; Affiliation:  1: National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA; Source Info: May1986, Vol. 13 Issue 5, p547; Subject Term: PERIODONTAL disease; Subject Term: CLINICAL trials; Subject Term: EPIDEMIOLOGY; Subject Term: GINGIVITIS; Subject Term: INDEXES; Subject Term: ORAL hygiene; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1600-051X.ep13603798
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kripke, Margaret L.
AU  - Morison, Warwick L.
T1  - Studies on the Mechanism of Systemic Suppression of Contact Hypersensitivity by UVB Radiation. II. Differences in the Suppression of Delayed and Contact Hypersensitivity in Mice.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/05//
VL  - 86
IS  - 5
M3  - Article
SP  - 543
EP  - 549
SN  - 0022202X
AB  - Exposing mice to UV radiation in the UVB range (280-320 nm) causes a selective immune suppression that contributes to the development of UVB-induced skin cancers. Among the immune responses suppressed by UVB irradiation are contact and delayed hypersensitivity reactions to haptens administered at unexposed sites. In these studies we provide evidence that delayed and contact hypersensitivity to the same hapten are not equivalent reactions and that they are suppressed in UVB-irradiated mice by 2 different mechanisms. This conclusion is based on the findings that: (1) suppression of contact hypersensitivity could not be overcome by immunizing UVB-irradiated mice with hapten-coupled antigen-presenting cells derived from normal donors; and (2) treatment of UVB-irradiated mice with methylprednisolone before immunization prevented the suppression of delayed hypersensitivity but had no effect on the suppression of contact hypersensitivity. The decreased ability to induce contact hypersensitivity in UVB-irradiated mice could be transferred to x-irradiated mice by reconstituting them with spleen cells from UVB- irradiated donors. The induction of hapten-specific suppressor cells, however, required both UVB irradiation and priming with hapten. Based on these results, we postulate that UVB irradiation induces a population of suppressor-inducer cells with specificity for a modified skin antigen and that this antigen serves as a carrier molecule for haptens that induce contact hypersensitivity and for tumor-specific transplantation antigens on UVB-induced tumors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNITY
KW  - HAPTENS
KW  - TUMORS
KW  - ULTRAVIOLET radiation
KW  - IRRADIATION
KW  - MICE as laboratory animals
KW  - CONTACT dermatitis
N1  - Accession Number: 12355000; Kripke, Margaret L. 1 Morison, Warwick L. 2; Affiliation:  1: University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas.  2: National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland, U.S.A.; Source Info: May86, Vol. 86 Issue 5, p543; Subject Term: IMMUNITY; Subject Term: HAPTENS; Subject Term: TUMORS; Subject Term: ULTRAVIOLET radiation; Subject Term: IRRADIATION; Subject Term: MICE as laboratory animals; Subject Term: CONTACT dermatitis; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12355000
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06436-023
AN  - 2006-06436-023
AU  - Tabakoff, Boris
T1  - Tolerance and Dependence: Novel Concepts and Molecular Mechanisms.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1986/05//
VL  - 31
IS  - 5
SP  - 357
EP  - 358
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06436-023. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tabakoff, Boris; Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Dependency; Drug Tolerance; Electrophysiology. Minor Descriptor: Biochemistry; Pharmacology. Classification: Physiological Psychology & Neuroscience (2500); Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Sharp, Charles W. (Ed). Mechanisms of Tolerance and Dependence. NIDA Research Monograph 54=Rockville, MD: National Institute on Drug Abuse, 1984. 389 pp. Free paperback; 1984. Page Count: 2. Issue Publication Date: May, 1986. 
AB  - Reviews the book, Mechanisms of Tolerance and Dependence. NIDA Research Monograph 54 by Charles W. Sharp (Ed.) (1984). The contributors to this book deftly review the current research on the cellular mechanisms by which drug tolerance and dependence are manifest. The contributors' efforts are concentrated on attempts to define the molecular and physiologic events that are generated by the continued exposure of neurons to opiates, barbiturates, amphetamines, cocaine, and nicotine. The monograph succeeds in presenting a detailed discourse in the areas of biochemical pharmacology and electrophysiology, but little attention is devoted to behavioral theories of tolerance and dependence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug tolerance
KW  - drug dependence
KW  - biochemical pharmacology
KW  - electrophysiology
KW  - behavioral theory
KW  - neurons
KW  - 1986
KW  - Drug Dependency
KW  - Drug Tolerance
KW  - Electrophysiology
KW  - Biochemistry
KW  - Pharmacology
KW  - 1986
U2  - Sharp, Charles W. (Ed). (1984); Mechanisms of Tolerance and Dependence. NIDA Research Monograph 54; Rockville, MD: National Institute on Drug Abuse, 1984. 389 pp. Free paperback
DO  - 10.1037/024748
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SHEN, D.-W.
AU  - FOJO, A.
AU  - CHIN, J. E.
AU  - RONINSON, I. B.
AU  - RICHERT, N.
AU  - PASTAN, I.
AU  - GOTTESMAN, M. M.
T1  - Human Mulidrug-Resistant Cell Lines: Increased mdrl Expression Can Precede Gene Amplificaton.
JO  - Science
JF  - Science
Y1  - 1986/05/02/
VL  - 232
IS  - 4750
M3  - Article
SP  - 643
EP  - 645
SN  - 00368075
AB  - The development of simultaneous resistance to multiple structurally unrelated drugs is a major impediment to cancer chemotherapy. Multidrug resistance in human KB carcinoma cells selected in colchicine, vinblastine, or Adriamycin is associated with amplification of specific DNA sequences (the multidrug resistance locus, mdrl). During colchicine selection resistance is initially accompanied by elevated expression of a 4.5-kilobase mdrl messenger RNA (mRNA) without amplification of the corresponding genomic sequences. During selection for inceased levels of resistance, expression of this mRNA is increased simultaneously with amplification of mdrl DNA. Increased expression and amplification of mdrl sequences were also found-in multidrug-resistant sublines of human leukemia and ovarian carcinoma cells. These results suggest that increased expression ofmdrl mRNA is a common mechanism for multidrug resistance in human cells. Activation of the mdrl gene by mutations or epigenetic changes may precede its amplification during the development of resistance. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87437269; SHEN, D.-W. 1 FOJO, A. 1 CHIN, J. E. 2 RONINSON, I. B. 2 RICHERT, N. 3 PASTAN, I. 3 GOTTESMAN, M. M. 3; Affiliation:  1: Laboratory ofMolecular Biology, National Cancer Institute, Betesda, MD 20892  2: Center for Genetics, University of Illinois College of Medicine at Chicago, Chicago, IL 60612  3: Laboratory of Molecular Biology, National Cancer Institutc, Bethesda, MD 20892; Source Info: 5/2/1986, Vol. 232 Issue 4750, p643; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - WALDMANN, THOMAS A.
T1  - The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes.
JO  - Science
JF  - Science
Y1  - 1986/05/09/
VL  - 232
IS  - 4751
M3  - Article
SP  - 727
EP  - 732
SN  - 00368075
AB  - Antigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine. Failure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response. The receptor is composed of a 33,000-dalton (251-amino acid) peptide precursor that is post-translationally glycosylated into the mature 55,000-dalton form. In contrast to resting T cells, human T-cell lymphotrophic virus I (HTLV-I)-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546959; WALDMANN, THOMAS A. 1; Affiliation:  1: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/9/1986, Vol. 232 Issue 4751, p727; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - RENLUND, MARTIN
AU  - TIETZE, FRANK
AU  - GAHL, WILLIAM A.
T1  - Defective Sialic Acid Egress from Isolated Fibroblast Lysosomes of Patients with Salla Disease.
JO  - Science
JF  - Science
Y1  - 1986/05/09/
VL  - 232
IS  - 4751
M3  - Article
SP  - 759
EP  - 762
SN  - 00368075
AB  - Normal fibroblasts exposed to N-acetylmannosamine yielded lysosome-rich granular fractions loaded with free (unbound) sialic acid, whose velocity of egress increased with increasing initial loading. Fibroblast granular fractions of patients with Salla disease exhibited negligible egress of sialic acid, whether endogenous or derived from N-acetylmannosamine exposure. Salla disease represents the first disorder demonstrated to be caused by defective transport of a monosaccharide out of cellular lysosomes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546953; RENLUND, MARTIN 1,2 TIETZE, FRANK 3 GAHL, WILLIAM A. 1; Affiliation:  1: Section on Human Biochemical Genetics, Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892  2: Children's Hospital, Helsinki University Central Hospital, 00290 Helsinki, Finland  3: Section on Developmental Biology, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892; Source Info: 5/9/1986, Vol. 232 Issue 4751, p759; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - NELSON, THOMAS
AU  - LUCIGNANI, GIOVANNI
AU  - SOKOLOFF, LOUIS
T1  - Measurement of Brain Deoxyglucose Metabolism by NMR.
JO  - Science
JF  - Science
Y1  - 1986/05/09/
VL  - 232
IS  - 4751
M3  - Article
SP  - 776
EP  - 777
SN  - 00368075
N1  - Accession Number: 87546936; NELSON, THOMAS 1 LUCIGNANI, GIOVANNI 1 SOKOLOFF, LOUIS 1; Affiliation:  1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20205; Source Info: 5/9/1986, Vol. 232 Issue 4751, p776; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GERSHON, ELLIOT S.
T1  - Quality of Intramural Research.
JO  - Science
JF  - Science
Y1  - 1986/05/23/
VL  - 232
IS  - 4753
M3  - Article
SP  - 919
EP  - 919
SN  - 00368075
N1  - Accession Number: 87546980; GERSHON, ELLIOT S. 1,2; Affiliation:  1: Office of Science, Alcohol, Drug Abuse, and Mental Health Administration, RockviUe, MD 20857  2: Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892; Source Info: 5/23/1986, Vol. 232 Issue 4753, p919; Number of Pages: 2/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BAX, AD
AU  - LERNER, LAURA
T1  - Two-Dimensional Nuclear Magnetic Resonance Spectroscopy.
JO  - Science
JF  - Science
Y1  - 1986/05/23/
VL  - 232
IS  - 4753
M3  - Article
SP  - 960
EP  - 967
SN  - 00368075
AB  - Great spectral simplification can be obtained by spreading the conventional one-dimensional nuclear magnetic resonance (NMR) spectrum in two independent frequency dimensions. This so-called two-dimensional NMR spectroscopy removes spectral overlap, facilitates spectral assignment, and provides a wealth of additional information. For example, conformational information related to interproton distances is available from resonance intensities in certain types of two-dimensional experiments. Another method generates 1H NMR spectra of a preselected fragment of the molecule, suppressing resonances from other regions and greatly simplifyig spectral appearance. Two-dimensional NMR spectroscopy can also be applied to the study of 13C and 15N, not only providing valuable connectivity information but also improving sensitivity of 13C and 15N detection by up to two orders of magnitude. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546975; BAX, AD 1 LERNER, LAURA 1; Affiliation:  1: Laboratory of Chemical Physics, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/23/1986, Vol. 232 Issue 4753, p960; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MAJEWSKA, MARIA DOROTA
AU  - HARRISON, NEIL L.
AU  - SCHWARTZ, ROCHELLE D.
AU  - BARKER, JEFFERY L.
AU  - PAUL, STEVEN M.
T1  - Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor.
JO  - Science
JF  - Science
Y1  - 1986/05/23/
VL  - 232
IS  - 4753
M3  - Article
SP  - 1004
EP  - 1007
SN  - 00368075
AB  - Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3α-hydroxy-5α-dihydroprogesterone and 3a,5a-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands ofthe -y-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10-7 and 10-5M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons. These data may explain the ability of certain steroid hormones to rapidly alter neuronal excitability and may provide a mechanism for the anesthetic and hypnotic actions of naturally occurring and synthetic anesthetic steroids. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546984; MAJEWSKA, MARIA DOROTA 1 HARRISON, NEIL L. 2 SCHWARTZ, ROCHELLE D. 1 BARKER, JEFFERY L. 2 PAUL, STEVEN M. 1; Affiliation:  1: Sections on Molecular Pharmacology and Preclinical Studies, Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892  2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/23/1986, Vol. 232 Issue 4753, p1004; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weinsier, Roland L.
AU  - Boker, John R.
AU  - Feldman, Elaine B.
AU  - Read, Merrill S.
AU  - Brooks, C. Michael
T1  - Nutrition knowledge of senior medical students: a collaborative study of southeastern medical schools.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/06//
VL  - 43
IS  - 6
M3  - Article
SP  - 959
EP  - 968
SN  - 00029165
AB  - The Southeastern Regional Medical-Nutrition Education Network (SERMEN) comprises 11 medical schools with varied nutrition training programs. A faculty representative from each school rated 41 topics in nutrition as to their importance for medical practice. From the seven topics unanimously chosen, a 90-item examination was prepared using the University of Alabama School of Medicine's Nutrition Test-Item Bank. Thirteen additional items surveyed student attitudes toward their nutrition training. Twenty-one percent of senior students from 10 SERMEN schools took the examination. Results showed significant variation in knowledge levels among the schools on the overall examination and on the seven topics. Eighty-five percent were dissatisfied with the quantity and 60% with the quality of their medical-nutrition education. Knowledge scores correlated with the students' assessments with r values of 0.28 and 0.35, respectively(p <0.001). Findings indicate significant variation in nutrition knowledge of US medical students. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Nutrition
KW  - Physiology
KW  - Medical students
KW  - Health occupations students
KW  - Medical schools
KW  - medical education
KW  - Nutrition education
KW  - nutrition teaching
N1  - Accession Number: 91253784; Weinsier, Roland L. 1; Boker, John R. 2; Feldman, Elaine B. 3; Read, Merrill S. 4; Brooks, C. Michael 2; Affiliations: 1: Department of Nutrition Sciences, University of Alabama, Birmingham; 2: Office of Educational Development, University of Alabama, Birmingham; 3: Nutrition Section of the Medical College of Georgia, Augusta, GA; 4: Clinical Nutrition and Early Development Branch, National Institute of Child Health and Human Development, Bethesda, MD; Issue Info: Jun1986, Vol. 43 Issue 6, p959; Thesaurus Term: Nutrition; Thesaurus Term: Physiology; Subject Term: Medical students; Subject Term: Health occupations students; Subject Term: Medical schools; Author-Supplied Keyword: medical education; Author-Supplied Keyword: Nutrition education; Author-Supplied Keyword: nutrition teaching; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Shock, Nathan W.
T1  - THE DEVELOPMENT OF AGING.
JO  - BioScience
JF  - BioScience
Y1  - 1986/06//
VL  - 36
IS  - 6
M3  - Book Review
SP  - 391
EP  - 391
SN  - 00063568
AB  - Reviews the book "Molecular Basis of Aging," edited by A.K. Roy and B. Chatterjee.
KW  - Aging
KW  - Nonfiction
KW  - Molecular Basis of Aging (Book)
N1  - Accession Number: 10106361; Shock, Nathan W. 1; Affiliations: 1: National Institute on Aging, Baltimore City Hospital, Baltimore, MD 21224; Issue Info: Jun86, Vol. 36 Issue 6, p391; Subject Term: Aging; Subject Term: Nonfiction; Reviews & Products: Molecular Basis of Aging (Book); Number of Pages: 2/3p; Document Type: Book Review; Full Text Word Count: 513
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Caughman, S. Wright
AU  - Breathnach, Stephen M.
AU  - Sharrow, Susan O.
AU  - Stephany, David A.
AU  - Katz, Stephen I.
T1  - Culture and Characterization of Murine Dendritic Thy-1+ Epidermal Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/06//
VL  - 86
IS  - 6
M3  - Article
SP  - 615
EP  - 624
SN  - 0022202X
AB  - Although numerous advances have been made in characterizing the phenotype, ontogeny, ultrastructure, and cyrochemistry of the murine Thy-1+ dendritic epidermal cell (Thy-1+ EC), elucidation of its functional qualities has been hampered by the difficulty in preparing pure populations of these cells. We therefore sought to obtain expanded, purified populations of Thy-1+ EC using culture techniques. Since Thy-1+ EC are bone marrow-derived, density gradient enriched populations of freshly harvested epidermal cells (FH-EC) were placed in culture under conditions known or suspected to promote mitogenesis among leukocyte subsets. FH-EC prepared from truncal skin of C3H/HeN mice (Thy-1.2+ ) were cultured at 37°C in 5% CO2 in complete medium (CM) of Eagle's Hanks' amino acid with 10% fetal calf serum, nutrients, and antibiotics at 106 FH-EC/well in 24-well culture plates. CM was supplemented with one or more of the following: concanavalin A (Con-A), interleukin-1 /epidermal cell-derived thymocyte-activating factor (IL-l/ETAF), IL-2, IL-3. γ interferon, indomethacin (IM), and anti-Thy-1.2 antibody. Media with appropriate supplements were changed every 2-3 days. Freshly isolated, enriched FH-EC contained 7-20% Thy-1+ EC (defined as brightly fluorescing cells readily distinguishable from weakly fluorescing keratinocytes), which also stained with antibodies directed against asialo GM1, Ly 5.1 , and vimentin but did not stain with antibodies to other T cell-, B cell- or macrophage phenotypic markers. Analysis of 10 separate cultures revealed a 3- to 10-fold expansion of nonkeratinocyte Thy-I ± cells after 21 ± 4 days in culture in CM supplemented with Con-A and IM, and 70-100% of viable cells after expansion were Thy- 1+. Phenotypic analysis of expanded cells revealed the emergence in 10 separate cultures of one two mutually exclusive distinct populations: one Thy- 1+, asialo GM1+, L3T4- (natural killer phenotype) and the other Thy- 1+, asialo GM1-, L3T4+ (T helper phenotype). Experiments designed to explain the emergence of an  L3T4+ population suggest that phenotypic modulation occurred in vitro. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENDRITIC cells
KW  - EPIDERMIS -- Diseases
KW  - MOUSE leukemia viruses
KW  - KERATINOCYTES
KW  - PHENOTYPE
KW  - DERMATOLOGY
N1  - Accession Number: 12275611; Caughman, S. Wright 1 Breathnach, Stephen M. 1 Sharrow, Susan O. 2 Stephany, David A. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jun86, Vol. 86 Issue 6, p615; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS -- Diseases; Subject Term: MOUSE leukemia viruses; Subject Term: KERATINOCYTES; Subject Term: PHENOTYPE; Subject Term: DERMATOLOGY; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1523-1747.ep12275611
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lamberg, Stanford I.
AU  - Yuspa, Stuart H.
AU  - Hascall, Vincent C.
T1  - Synthesis of Hyaluronic Acid Is Decreased and Synthesis of Proteoglycans Is Increased When Cultured Mouse Epidermal Cells Differentiate.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/06//
VL  - 86
IS  - 6
M3  - Article
SP  - 659
EP  - 667
SN  - 0022202X
AB  - New born mouse epidermal cells proliferate when cultured in 0.5 mM Ca++ medium and terminally differentiate when the Ca++ is increased to about 1.2 mM, the level found in most cell culture media. We found that hyaluronic acid and proteoglycans were synthesized by isolated cultured newborn mouse epidermal cells and that quantitative and qualitative changes in these macromolecules appeared when proliferating epidermal cultures were induced to differentiate by calcium. A major change that occurred with differentiation was a reduction in synthesis of hyaluronic acid while synthesis of proteoglycans and glycoproteins increased. The proteoglycans synthesized in these cultures were heparan sulfate-proteoglycan (90%) and chondroitin sulfate-proteoglycan (10%), regardless of the calcium level. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYALURONIC acid
KW  - MUCOPOLYSACCHARIDES
KW  - PROTEOGLYCANS
KW  - GLYCOPROTEINS
KW  - EPIDERMIS
KW  - DERMATOLOGY
N1  - Accession Number: 12275707; Lamberg, Stanford I. 1 Yuspa, Stuart H. 2 Hascall, Vincent C. 3; Affiliation:  1: Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, U.S.A.  2: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.  3: Bone Research Branch, National Institute of Dental Research, Bethesda, Maryland. U.S.A.; Source Info: Jun86, Vol. 86 Issue 6, p659; Subject Term: HYALURONIC acid; Subject Term: MUCOPOLYSACCHARIDES; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; Subject Term: EPIDERMIS; Subject Term: DERMATOLOGY; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1523-1747.ep12275707
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Personality, coping, and coping effectiveness in an adult sample.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1986/06//
VL  - 54
IS  - 2
M3  - Article
SP  - 385
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Two studies of coping among community-dwelling adults (N = 255, 151) were used to examine the influence of personalty on coping responses, the perceived effectiveness of coping mechanisms, and the effects of coping and personality on well-being. In both studies a wide range of potential stressors was examined, categorized as losses, threats, or challenges. The personality dimensions of neuroticism, extraversion, and openness to experience, as measured by both selfreports and spouse- and peer-ratings, were systematically related to coping mechanisms in both studies. There was general agreement across types of stressors on the use and perceived effectiveness of the 27 coping mechanisms, and individuals who used more effective ways of coping generally reported higher subsequent happiness and life satisfaction. However, personality variables are also known to be determinants of well-being, and the associations between coping and well-being were reduced when personality measures were partialled out. Some implications for the design and interpretation of coping effectiveness studies are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - CONSCIOUSNESS
KW  - PSYCHOLOGY
KW  - ADJUSTMENT (Psychology)
KW  - WELL-being
KW  - HAPPINESS
KW  - LIFE CYCLE: ADULTHOOD AND THE FAMILY
N1  - Accession Number: 8970678; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Jun86, Vol. 54 Issue 2, p385; Subject Term: PERSONALITY; Subject Term: CONSCIOUSNESS; Subject Term: PSYCHOLOGY; Subject Term: ADJUSTMENT (Psychology); Subject Term: WELL-being; Subject Term: HAPPINESS; Author-Supplied Keyword: LIFE CYCLE: ADULTHOOD AND THE FAMILY; Number of Pages: 21p; Document Type: Article
L3  - 10.1111/1467-6494.ep8970678
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
AU  - Busch, Catherine M.
T1  - Evaluating comprehensiveness in personality systems: The California Q-Set and the five-factor model.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1986/06//
VL  - 54
IS  - 2
M3  - Article
SP  - 430
PB  - Wiley-Blackwell
SN  - 00223506
AB  - The analysis of natural language trait names and questionnaire scales has suggested that the five factors of Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness constitute an adequate taxonomy of personality. An alterantive approach to comprehensive personality assessment based on clinical judgments is given by the California Q-Set (COS, Block, 1961). When self-Qsorts from 403 adult men and women were factored, the five factors closely resembled those found m adjectives, and showed convergent and discriminant validity against self-reports and peer- and spouse-ratings on measures of the fivefactor model Results were replicated when interviewer Q-sort ratings were examined for a subset of subjects. These findings strongly support the claim to comprehensiveness of the five-factor model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - CONSCIOUSNESS
KW  - PSYCHOLOGY
KW  - PERSONALITY assessment
KW  - QUESTIONNAIRES
KW  - CALIFORNIA
KW  - UNITED States
N1  - Accession Number: 8970694; McCrae, Robert R. 1 Costa Jr., Paul T. 1 Busch, Catherine M. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Jun86, Vol. 54 Issue 2, p430; Subject Term: PERSONALITY; Subject Term: CONSCIOUSNESS; Subject Term: PSYCHOLOGY; Subject Term: PERSONALITY assessment; Subject Term: QUESTIONNAIRES; Subject Term: CALIFORNIA; Subject Term: UNITED States; Number of Pages: 17p; Document Type: Article
L3  - 10.1111/1467-6494.ep8970694
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Smith, C. A. D.
AU  - Rushton, P.
AU  - Bray, C. M.
T1  - Polyadenylated RNA metabolism and loss of vigour and viability in germinating wheat embryos.
JO  - Physiologia Plantarum
JF  - Physiologia Plantarum
Y1  - 1986/06//
VL  - 67
IS  - 2
M3  - Article
SP  - 310
EP  - 314
SN  - 00319317
AB  - The quiescent wheat (<em>Triticum aestivum</em> L. cv. Hobbit) embryo contains polyadenylated RNA species (polyA+ RNA, presumptive mRNA species) which are rapidly degraded upon water imbibition by the embryo even when the embryo has lost viability. The level of polyA+ RNA species in the quiescent embryo does not reflect the vigour or viability rating of the seed lot. Embryos which have lost viability appear to have lost the capacity for de novo transcription of poIyA+ RNA species during the hours following water imbibition by the embryo. Embryos from seed lots of differing vigour ratings can be distinguished by their very different patterns of poIyA+ RNA metabolism during germination at a sub-optimal temperature. In embryos of reduced vigour there is a delayed onset of degradation of polyA+ RNA species during germination at 10°C and a reduced rate of polyA+ RNA synthesis through the first 6 h of germination compared with these processes in high vigour embryos. However, at later germination stages embryos of reduced vigour synthesise polyA+ RNA species at rates similar to those found in high vigour embryos yet newly synthesised Poly+ RNA species accumulate in embryos of reduced vigour only to a level which is 50% of that found in high vigour embryos of comparable viability. Results suggest that additional lesions affecting the stability and/or turnover of the messenger ribonucleo-protein complex containing poIyA+RNA are present in embryos of reduced vigour at later stages of germination at a sub-optimal temperature. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MESSENGER RNA
KW  - METABOLISM
KW  - NUCLEIC acids
KW  - PLANT physiology
KW  - PROTEIN synthesis
KW  - BIOSYNTHESIS
KW  - Protein biosynthesis.
N1  - Accession Number: 12909809; Smith, C. A. D. 1 Rushton, P. 2 Bray, C. M. 2; Affiliation:  1: Department of Health & Human Services, National Institute of Health, National Cancer Institute, Bethesda, MD 20205, U.S.A.  2: Department of Biochemistry, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.; Source Info: Jun86, Vol. 67 Issue 2, p310; Subject Term: MESSENGER RNA; Subject Term: METABOLISM; Subject Term: NUCLEIC acids; Subject Term: PLANT physiology; Subject Term: PROTEIN synthesis; Subject Term: BIOSYNTHESIS; Author-Supplied Keyword: Protein biosynthesis.; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1399-3054.ep12909809
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ISHII, SHUNSUKE
AU  - KADONAGA, JAMES T.
AU  - TJIAN, ROBERT
AU  - BRADY, JOHN N.
AU  - MERLINO, GLENN T.
AU  - PASTAN, IRA
T1  - Binding of the Spl Transcription Factor by the Human Harvey rasl Proto-oncogene Promoter.
JO  - Science
JF  - Science
Y1  - 1986/06/13/
VL  - 232
IS  - 4756
M3  - Article
SP  - 1410
EP  - 1413
SN  - 00368075
AB  - Members of the ras gene family encode proteins that when overproduced or mutated can transform immortalized mammalian cells. It is therefore important to understand the mechanisms by which the ras genes are regulated. The promoter region of the human Harvey ras proto-oncogene c-Ha-rasl initiates RNA transcription at multiple sites and contains repeated copies of the hexanucleotide GGGCGG' nd its inverted complement CCGCCC, referred to as GC boxes. These GC boxes consist of sequences identical to those found in the SV40 early promoter, where the human cellular transcriptional factor Spl binds. Footprinting analysis with deoxyribonuclease I was used to show that Spl binds to six GC box sequences within the c-Ha-rasl promoter. An in vivo transfection assay showed competition between the 21-base pair repeats of the SV40 promoter and the c-Ha-rasl promoter for common regulatory factors. In this system the presence of Spl is ap,parently required for c-Ha-rasl transcription. Analysis of deletions of the c-Ha-rasl promoter region by means of a transient expression assay revealed that the three Spl binding sites closest to the RNA start sites were sufficient for full transcriptional activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546722; ISHII, SHUNSUKE 1 KADONAGA, JAMES T. 2 TJIAN, ROBERT 2 BRADY, JOHN N. 3 MERLINO, GLENN T. 1 PASTAN, IRA 1; Affiliation:  1: Laboratory of Molecular Biology, Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892  2: Department of Biochemistry, University of California, Berkeley, CA 94720  3: Laboratory of Molecular Virology, Division of Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 6/13/1986, Vol. 232 Issue 4756, p1410; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DICKSON, ROBERT B.
AU  - MCMANAWAY, MARY E.
AU  - LIPPMAN, MARC E.
T1  - Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth.
JO  - Science
JF  - Science
Y1  - 1986/06/20/
VL  - 232
IS  - 4757
M3  - Article
SP  - 1540
EP  - 1543
SN  - 00368075
AB  - The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were suient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus pardally replacing estradiol. Growth factors may act as estrogen-induced "second messengers" in estrogen responsive growth of human breast cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546750; DICKSON, ROBERT B. 1 MCMANAWAY, MARY E. 1 LIPPMAN, MARC E. 1; Affiliation:  1: Medical Breast Cancer Section, Medicine Branch, National Cancer Institute, Bethcsda, MD 20892; Source Info: 6/20/1986, Vol. 232 Issue 4757, p1540; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HAHN, BEATRICE H.
AU  - SHAW, GEORGE M.
AU  - TAYLOR, MARIA E.
AU  - REDFIELD, ROBERT R.
AU  - MARKHAM, PHIL D.
AU  - SALAHUDDIN, S. Z.
AU  - WONG-STAAL, FLOSSIE
AU  - GALLO, ROBERT C.
AU  - PARKS, ELIZABETH S.
AU  - PARKS, WADE P.
T1  - Genetic Variation in HTLV-III/LAV Over Time in Patients with AIDS or at Risk for AIDS.
JO  - Science
JF  - Science
Y1  - 1986/06/20/
VL  - 232
IS  - 4757
M3  - Article
SP  - 1548
EP  - 1553
SN  - 00368075
AB  - In a study of genetic variation in the AIDS virus, HTLV-III/LAV, sequential virus isolates from persistently infected individuals were examined by Southern blot genomic analysis, molecular doning, and nucleotide sequencing. Four to six virus isolates were obtained from each of three individuals over a 1-year or 2-year period. Changes were detected throughout the viral genomes and consisted of isolated and clustered nucleotide point mutations as well as short deletions or insertions. Results from genomic restriction mapping and nucleotide sequence comparisons indicated that viruses isolated sequentially had evolved in parallel from a common progenitor virus. The rate of evolution of HTLV-III/LAV was estimated to be at least 10-3 nucleotide substitutions per site per year for the env gene and 10-4 for thegag gene, values a millionfold greater than for most DNA genomes. Despite this relatively rapid rate of sequence divergence, virus isolates from any one patient were all much more related to each other than to viruses from other individuals. In view of the substantial heterogeneity among most independent HTLV-III/LAV isolates, the repeated isolation from a given individual of only highly related viruses raises the possibility that some type of interference mechanism may prevent simultaneous infection by more than one major genotypic form of the virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87546763; HAHN, BEATRICE H. 1 SHAW, GEORGE M. 1 TAYLOR, MARIA E. 1 REDFIELD, ROBERT R. 2 MARKHAM, PHIL D. 3 SALAHUDDIN, S. Z. 3 WONG-STAAL, FLOSSIE 3 GALLO, ROBERT C. 3 PARKS, ELIZABETH S. 4 PARKS, WADE P. 4; Affiliation:  1: Division of Hematology and Oncology, University of Alabama Medical Center, Birmingham, AL 35294  2: Department of Virus Diseases, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC 20307  3: Laboratory of Tumor Cell Biology, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20205  4: Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101; Source Info: 6/20/1986, Vol. 232 Issue 4757, p1548; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nakao, Keiko
AU  - Milazzo-Sayre, Laura J.
AU  - Rosenstein, Marilyn J.
AU  - Manderscheid, Ronald W.
T1  - Referral Patterns to and from Inpatient Psychiatric Services: A Social Network Approach.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/07//
VL  - 76
IS  - 7
M3  - Article
SP  - 755
EP  - 760
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Interorganizational linkages have assumed more import for mental health service systems during the past three decades because of increased levels of complexity in service delivery patterns. This analysis examines these linkages from a relational perspective, with network of patient referral patterns as the basic unit. Multidimensional scaling is employed to discern patterns of interorganizational linkages in national patient referral data collected by the National Institute of Mental Health m 1975 and 1980 for patient samples from inpatient psychiatric services of state and county mental hospitals, private psychiatric hospitals, and public and nonpublic general hospitals. The multidimensional scaling techniques distinguish two structural characteristics of the interorganizational linkages of psychiatric inpatient services--public vs private services, and drift over time in referral patterns. Public and private inpatient psychiatric services are differentiated principally in terms of ° of interaction with legal agencies and private practice psychiatrists. Chronological change in referral patterns is characterized principallly by changes in the ° of interaction with other inpatient or outpatient psychiatric services. Methodologically and theoretically, the techniques and findings described can enhance our understanding of interorganizational linkages and dynamics. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSYCHIATRIC referral
KW  - CONSULTATION-liaison psychiatry
KW  - MEDICAL referral
KW  - MENTAL health services
KW  - MULTIDIMENSIONAL scaling
KW  - PSYCHOLOGICAL tests
KW  - PSYCHIATRISTS
KW  - OUTPATIENT medical care
KW  - UNITED States
KW  - NATIONAL Institute of Mental Health (U.S.)
N1  - Accession Number: 4687181; Nakao, Keiko 1 Milazzo-Sayre, Laura J. 1 Rosenstein, Marilyn J. 1 Manderscheid, Ronald W. 2; Affiliation:  1: Chief, Survey and Reports Branch, DBE, National Institute of Mental Health, DHHS, PHS, Room 18C-07 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857  2: Department of Sociology, University of California, Los Angeles; Source Info: Jul1986, Vol. 76 Issue 7, p755; Subject Term: PSYCHIATRIC referral; Subject Term: CONSULTATION-liaison psychiatry; Subject Term: MEDICAL referral; Subject Term: MENTAL health services; Subject Term: MULTIDIMENSIONAL scaling; Subject Term: PSYCHOLOGICAL tests; Subject Term: PSYCHIATRISTS; Subject Term: OUTPATIENT medical care; Subject Term: UNITED States; Company/Entity: NATIONAL Institute of Mental Health (U.S.); NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simon, Jean
AU  - Leroith, Derek
T1  - Insulin receptors of chicken liver and brain.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1986/07//7/1/86
VL  - 158
IS  - 1
M3  - Article
SP  - 125
EP  - 132
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Discusses results of a study characterizing the alpha and beta subunit properties of the insulin receptors of chicken liver and brain.  Insulin potency ratios; Apparent binding affinity; Effect of neuraminidase on mobility of alpha subunit from liver; Best artificial substrate for phosphorylation; Molecular mass.
KW  - INSULIN
KW  - ALPHA adrenoceptors
KW  - BETA adrenoceptors
KW  - LIVER
KW  - BRAIN
KW  - NEURAMINIDASE
N1  - Accession Number: 12234053; Simon, Jean 1 Leroith, Derek 1; Affiliation:  1: Diabetes Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health; Source Info: 7/1/86, Vol. 158 Issue 1, p125; Subject Term: INSULIN; Subject Term: ALPHA adrenoceptors; Subject Term: BETA adrenoceptors; Subject Term: LIVER; Subject Term: BRAIN; Subject Term: NEURAMINIDASE; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eun Sul Lee
AU  - Forthofer, Ronald N.
AU  - Holzer III, Charles E.
AU  - Taube, Carl A.
T1  - Complex Survey Data Analysis: Estimation of Standard Errors Using Pseudostrata.
JO  - Journal of Economic & Social Measurement
JF  - Journal of Economic & Social Measurement
Y1  - 1986/07//
VL  - 14
IS  - 2
M3  - Article
SP  - 135
EP  - 144
PB  - IOS Press
SN  - 07479662
AB  - A proper analysis of data from complex sample surveys requires special consideration for estimating standard errors. Special techniques and software packages are available, including Taylor series linearization (delta method), balanced repeated replication, and jackknife. Before their use, it is often necessary to make certain modifications in original data structure, to conform to computing method requirements. The most common modification is to form pseudostrata by collapsing substrata or partitioning a string of geographic clusters. This paper examines the performance of the delta method when it is applied to a complex community survey data set in which sequentially drawn clusters of households are partitioned to form pseudostrata. Standard errors of rates, regression coefficients, and odds ratios are compared with those computed from the variation of replicates built into the sample design. The results demonstrate that an analysis of complex survey data should use an appropriate method for estimating standard errors, and that pseudostrata would produce reasonable estimates of standard errors for rates and regression coefficients, with mixed results for odds ratios. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SAMPLING (Statistics)
KW  - DEMOGRAPHIC surveys
KW  - REGRESSION analysis
KW  - MATHEMATICAL statistics
KW  - COMPUTER software
KW  - JACKKNIFE (Statistics)
KW  - SOCIAL surveys
KW  - SOCIAL science research
KW  - UNITED States
N1  - Accession Number: 6641950; Eun Sul Lee 1; Forthofer, Ronald N. 1; Holzer III, Charles E. 2; Taube, Carl A. 3; Affiliations: 1: University of Texas Health Science Center, Houston; 2: University of Texas Medical Branch, Galveston; 3: National Institute of Mental Health; Issue Info: Jul86, Vol. 14 Issue 2, p135; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: DEMOGRAPHIC surveys; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: COMPUTER software; Subject Term: JACKKNIFE (Statistics); Subject Term: SOCIAL surveys; Subject Term: SOCIAL science research; Subject: UNITED States; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Shimada, Shinji
AU  - Schwartz, Ronald H.
AU  - Katz, Stephen I.
T1  - Development and Characterization of Trinitrophenyl-Specific L3T4+ T-Cell Clones.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/07//
VL  - 87
IS  - 1
M3  - Article
SP  - 24
EP  - 29
SN  - 0022202X
AB  - Two antigen-specific, L3T4+4, Lyt-2- T-cell clones have been developed from (C57BL/6 × C3H/HeN) F1 mice epicutaneously sensitized to trinitrochlorohenzene. Genetic mapping and antibody blocking studies demonstrated that both of these clones have specificity for trinitrophenyl in association with Eβk:Eαk or Eβb:Eαk Ia molecules. One of the clones (D-8) also recognizes nonhaptenated cells expressing Eβs: Eαk. These clones should provide useful tools for the assessment of the signals required for triggering immune responses to haptenated self antigens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - MICE
KW  - NITROGLYCERIN
KW  - GENE mapping
KW  - LYMPHOCYTES
KW  - GENETIC techniques
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 12523527; Shimada, Shinji 1 Schwartz, Ronald H. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Laboratory of Immunology, National Institute of Allergy, Bethesda, Maryland. U.S.A.  2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland. U.S.A.; Source Info: Jul86, Vol. 87 Issue 1, p24; Subject Term: T cells; Subject Term: MICE; Subject Term: NITROGLYCERIN; Subject Term: GENE mapping; Subject Term: LYMPHOCYTES; Subject Term: GENETIC techniques; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325920 Explosives Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12523527
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson Jr., Ray
T1  - A Triarchic Model of P300 Amplitude.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1986/07//
VL  - 23
IS  - 4
M3  - Article
SP  - 367
EP  - 384
SN  - 00485772
AB  - A model of P300 amplitude is proposed that reduces the many hypothetical constructs invoked to explain variations in P300 amplitude to three dimensions: 1) Subjective Probability, 2) Stimulus Meaning, and 3) Information Transmission. Evidence is presented to support the assertion that variables on the subjective probability and stimulus meaning dimensions have independent and additive contributions to overall P300 amplitude. The amplitude contributions of both of these dimensions, however, are modulated by a multiplicative relation with the proportion of transmitted stimulus information. Within each dimension, the fundamental experimental variables and their interrelations are specified. An example is presented to show how, by using an additive factors method, the respective amplitude effects of the probability and stimulus meaning dimensions can be separated. Supporting data are presented to show that the proposed model provides a reasonable and testable framework in which to conceptualize P300 results. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSYCHOPHYSIOLOGY
KW  - ELECTROPHYSIOLOGY
KW  - EVOKED potentials (Electrophysiology)
KW  - LATENT variables
KW  - NEUROLOGY
N1  - Accession Number: 11022771; Johnson Jr., Ray 1; Affiliation:  1: National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke, Medical Neurology Branch, Bethesda, Maryland.; Source Info: Jul1986, Vol. 23 Issue 4, p367; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: ELECTROPHYSIOLOGY; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: LATENT variables; Subject Term: NEUROLOGY; Number of Pages: 18p; Document Type: Article
L3  - 10.1111/1469-8986.ep11022771
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Djeu, Julie Y.
AU  - Kasahara, T.
AU  - Balow, J. E.
AU  - Tsokos, G. C.
T1  - Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1986/08//
VL  - 65
IS  - 2
M3  - Article
SP  - 279
EP  - 285
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The lymphokine, interleukin 2 (IL-2), is an important modulator of cell-mediated immune (CMI) responses. We report here the detection of an inhibitor of IL-2 in normal sera by measuring the inhibition of thymidine incorporation in IL-2 dependent murine CTLL cells. The inhibitor, partially purified by Sephacryl S-200 gel filtration, eluted with the 60,000-70,000 mol. wt fraction. The factor was destroyed at 56 °C for 30 min and did not bind to Protein A Sepharose, suggesting that it is not an immunoglobulin G. Of 26 normal sera tested, 23 had significant levels of the inhibitor. Since connective tissue diseases are often associated with deficient CMI responses, we examined the levels of IL-2 inhibitor in 26 systemic lupus erythematosus (SLE) and 22 rheumatoid arthritis (RA) patients. Only 8 SLE and 12 RA patients had normal levels of the inhibitor. Of the 18 SLE patients with low or undetectable levels, 15 had clinically defined active disease and of the eight with normal levels, three had active disease. The decrease In the IL-2 inhibitor level did not correlate either with steroid or cyctophosphamide treatment or with serum levels of DNA binding and C3. These data suggest that the function of the inhibitor is to control IL-2 activity under normal conditions. Decreased levels of the IL-2 inhibitor in these patients might be explained either as a reduced requirement of this regulatory protein secondary to decreased IL-2 production or a defect of the cells responsible for the production of both IL-2 and its inhibitor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - AUTOIMMUNE diseases
KW  - SYSTEMIC lupus erythematosus
KW  - RHEUMATOID arthritis
KW  - BLOOD plasma
KW  - PATIENTS
KW  - cell-mediated
KW  - immune responses
KW  - interleukin 2 inhibitor
KW  - rheumatoid arthritis
KW  - Systemic lupus erythematosus
N1  - Accession Number: 16099087; Djeu, Julie Y. 1 Kasahara, T. 1 Balow, J. E. 2 Tsokos, G. C. 2; Affiliation:  1: Department of Microbiology, University of Southern Florida, Tampa, Florida.  2: Kidney Disease Section,National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. USA.; Source Info: Aug1986, Vol. 65 Issue 2, p279; Subject Term: INTERLEUKIN-2; Subject Term: AUTOIMMUNE diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: RHEUMATOID arthritis; Subject Term: BLOOD plasma; Subject Term: PATIENTS; Author-Supplied Keyword: cell-mediated; Author-Supplied Keyword: immune responses; Author-Supplied Keyword: interleukin 2 inhibitor; Author-Supplied Keyword: rheumatoid arthritis; Author-Supplied Keyword: Systemic lupus erythematosus; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rasinowitz, Ruth
AU  - Pescovitz, M. D.
AU  - Sachs, D. H.
T1  - Anti-idiotype to monoclonal anti-swine SLA antibody detects a common idiotype shared by mouse anti-SLA sera and elicits an anti-SLA activity.
JO  - Immunology
JF  - Immunology
Y1  - 1986/08//
VL  - 58
IS  - 4
M3  - Article
SP  - 607
EP  - 613
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Heterologous anti-idiotypic reagents have been prepared against a BALB/c anti-swine MHC (SLAd) monoclonal antibody (74-11-10) in order to test for possible interspecies idiotypic cross-reactions of anti-MHC antibodies. Using these reagents to examine xenoantisera produced in BALH/c mice immunized with swine SLAdd peripheral blood lymphocytes, all animals tested were found to express detectable levels of the 74-11-10 idiotype (Id). The Id could also be detected in one out of five BALB/c mice immunized with swine SLAcc PBL. Swine anti-SLAdd alloantibodies were also tested, but failed to show detectable levels of the 74-11-10 Id. The in vivo administration of anti-idiotypic reagents to BALI/c mice induced detectable levels of 74-11-10 Id positive antibodies that bound specifically to SLAdd PHL. Similar treatment of SLAgg swine (recombinant swine expressing the class I MHC molecules of c) with anti-idiotypic antibodies failed to induce anti-SLAd antibody activity. These results thus indicate that 74-11-10 represents a shared idiotype of BA LB/c anti-SLAdd antibodies. The presence of 74-11-10 Id in one mouse immunized with SLA∞ PBL suggests that the failure of pigs to express the 74-11-10 Id following treatment with anti-idiotypic antibodies may be the result of tolerance rather than absence of the relevant variable region gene(s). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - ANTI-idiotypic antibodies
KW  - SWINE
KW  - MICE
KW  - IMMUNIZATION
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 14006879; Rasinowitz, Ruth 1 Pescovitz, M. D. 1 Sachs, D. H. 1; Affiliation:  1: Transplantation Biology Section, Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug86, Vol. 58 Issue 4, p607; Subject Term: MONOCLONAL antibodies; Subject Term: ANTI-idiotypic antibodies; Subject Term: SWINE; Subject Term: MICE; Subject Term: IMMUNIZATION; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanley, John R.
AU  - Klaus-Kovtun, Vera
AU  - Sampaio, Sebastiao A. P.
T1  - Antigenic Specificity of Fogo Selvagem Autoantibodies Is Similar to North American Pemphigus Foliaceus and Distinct from Pemphigus Vulgaris Autoantibodies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/08//
VL  - 87
IS  - 2
M3  - Article
SP  - 197
EP  - 201
SN  - 0022202X
AB  - Fogo selvagem (PS) is clinically, histologically, and immunopathologically similar to sporadic pemphigus foliaceus (PE, as seen in North America and Europe), although the epidemiology of these 2 diseases differs markedly. It has been proposed that FS is identical to PF but, for some reason, occurs in an endemic focus in central Brazil. If this hypothesis is correct, the autoantibodies in FS and PF should have similar antigenic specificities. We studied sera from 13 patients with FS from central Brazil, and compared them with 20 sera from patients with PF from the United States. All these sera had circulating antibodies that bound the cell surface of epithelial cells in identical patterns by indirect immunofluorescence on monkey esophagus or normal human skin. In immunoprecipitation studies none of the 13 FS sera precipitated the pemphigus vulgaris (PV) antigen from radiolabeled extracts of cultured human keratino- cytes. This is similar to the findings with PF sera of which 19 of 20 sera did not react with PV antigen, but in sharp contrast to the results with PV sera which, as previously reported, all immunoprecipitate the PV antigen. Immunoblotting performed on extracts of normal human epidermis demonstrated that 7 of 20 PF sera specifically and intensely bound an approximately 160 kD polypeptide, previously identified as desmoglein I, a desmosomal glycoprotein. Similarly, 3 of 13 FS sera specifically bound a 160 kD polypeptide. Thirteen normal sera from North America, 8 normal and disease control sera from central Brazil, 11 PV sera, and 12 bullous pemphigoid sera did not specifically bind this polypeptide. Two-dimensional gel electrophoresis confirmed that the 160 kD polypeptides identified by the subgroup of PF and FS sera were identical. These studies demonstrate that, although the exact molecular specificities of the majority of PF and FS sera remain to be determined, FS autoantibodies do not bind the PV antigen and a subgroup of FS autoantibodies have molecular specificity identical to that of a subgroup of PF auto-antibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEMPHIGUS
KW  - ANTIGENS
KW  - IMMUNOSPECIFICITY
KW  - AUTOANTIBODIES -- Analysis
KW  - EPIDEMIOLOGY
KW  - NORTH America
KW  - EUROPE
N1  - Accession Number: 12695334; Stanley, John R. 1 Klaus-Kovtun, Vera 1 Sampaio, Sebastiao A. P. 2; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Division of Dermatology, São Paulo University, São Paulo, Brazil.; Source Info: Aug86, Vol. 87 Issue 2, p197; Subject Term: PEMPHIGUS; Subject Term: ANTIGENS; Subject Term: IMMUNOSPECIFICITY; Subject Term: AUTOANTIBODIES -- Analysis; Subject Term: EPIDEMIOLOGY; Subject Term: NORTH America; Subject Term: EUROPE; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12695334
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DiGiovanna, John J.
AU  - Fletcher, R. Theodore
AU  - Chader, Gerald J.
T1  - REPLY.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/08//
VL  - 87
IS  - 2
M3  - Article
SP  - 296
EP  - 296
SN  - 0022202X
AB  - Presents a response by authors to a letter to the editor regarding their article on measurement of cellular retinol-binding protein in human dermis, published in the August 1986 issue of the "Journal of Investigative Dermatology."
KW  - DERMIS
KW  - LETTERS to the editor
N1  - Accession Number: 12696814; DiGiovanna, John J. 1 Fletcher, R. Theodore 1 Chader, Gerald J. 1; Affiliation:  1: National Institutes of Health Bethesda, Maryland; Source Info: Aug86, Vol. 87 Issue 2, p296; Subject Term: DERMIS; Subject Term: LETTERS to the editor; Number of Pages: 1/2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12696814
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hofferth, Sandra L.
T1  - Response to a Comment by Bumpass on "Updating Children's Life Course.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1986/08//
VL  - 48
IS  - 3
M3  - Article
SP  - 680
EP  - 682
SN  - 00222445
AB  - This section presents a rely to a comment on the article "Updating Children's Life Course." The primary reason why numbers are different is that very different things are being estimated. In addition, although everybody wants the bottom line, obtaining that number is very difficult. The author of the article has done a real service with his two very careful studies of the experience of children, the first in 1979 and the second in 1984. All studies are restricted by the fact that the most recent cohorts of children have not experienced their full childhood, and therefore, does not know what their experience will be.
KW  - CHILD rearing
KW  - EXPERIENCE
KW  - COGNITION
KW  - HUMAN life cycle
KW  - CHILD development
KW  - CHILD psychology
KW  - CHILD care
N1  - Accession Number: 5273526; Hofferth, Sandra L. 1; Affiliation:  1: Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute of Child Health and Human Development, 7910 Woodmont Ave., Room 7C25, Bethesda, MD 20892; Source Info: Aug86, Vol. 48 Issue 3, p680; Subject Term: CHILD rearing; Subject Term: EXPERIENCE; Subject Term: COGNITION; Subject Term: HUMAN life cycle; Subject Term: CHILD development; Subject Term: CHILD psychology; Subject Term: CHILD care; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SPORN, MICHAEL B.
AU  - ROBERTS, ANITA B.
AU  - WAKEFIELD, LALAGE M.
AU  - ASSOIAN, RICHARD K.
T1  - Transforming Growth Factor-β Biological Function and Chemical Structure.
JO  - Science
JF  - Science
Y1  - 1986/08//8/1/1986
VL  - 233
IS  - 4763
M3  - Article
SP  - 532
EP  - 534
SN  - 00368075
AB  - Transforming growth factor-β (TGF-β) is a multifimctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-β and essentially all of them have specific receptors for this peptide. TGF-β regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519496; SPORN, MICHAEL B. 1 ROBERTS, ANITA B. 1 WAKEFIELD, LALAGE M. 1 ASSOIAN, RICHARD K. 1; Affiliation:  1: Laboratory of Chemoprevention, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892; Source Info: 8/1/1986, Vol. 233 Issue 4763, p532; Number of Pages: 3p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - JAYE, MICHAEL
AU  - HOWK, RICHARD
AU  - BURGESS, WILSON
AU  - RICCA, GEORGE A.
AU  - ING-MING CHIU
AU  - RAVERA, MARK W.
AU  - O'BRIEN, STEPHEN J.
AU  - MODI, WILLIAM S.
AU  - MACIAG, THOMAS
AU  - DROHAN, WILLIAM N.
T1  - Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization.
JO  - Science
JF  - Science
Y1  - 1986/08//8/1/1986
VL  - 233
IS  - 4763
M3  - Article
SP  - 541
EP  - 545
SN  - 00368075
AB  - Several of the endothelial cell polypeptide mitogens that have been described probably play a role in blood vessel homeostasis. Two overlapping complementary DNA clones encoding human endothelial cell growth factor (ECGF) were isolated from a human brain stem complementary DNA library. Southern blot analysis suggested that there is a single copy of the ECGF gene and that it maps to human chromosome 5 at bands 5q31.3 to 33.2. A 4.8-kilobase messenger RNA was present in human brain stem messenger RNA. The complete amino acid sequence of human ECGF was deduced from the nucleic acid sequence ofthese dones; it encompasses all the well-characterized acidic endothelial cell polypeptide mitogens described by several laboratories. The ECGF-encoding open reading frame is flanked by tranislation stop codons and provides no signal peptide or internal hydrophobic domain for the secretion ofECGF. This property is shared by human interleukin-1, which is approximately 30 percent homologous to ECGF. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519523; JAYE, MICHAEL 1 HOWK, RICHARD 2 BURGESS, WILSON 2 RICCA, GEORGE A. 1 ING-MING CHIU 1 RAVERA, MARK W. 1 O'BRIEN, STEPHEN J. 3 MODI, WILLIAM S. 3 MACIAG, THOMAS 2 DROHAN, WILLIAM N. 1; Affiliation:  1: Molecular Biology Division, Meloy Laboratories, Springfield, VA 22151  2: Department of Cell Biology, Biotechnology Research Center, Rockville, MD 208502  3: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research Center, Frederick, MD 21701; Source Info: 8/1/1986, Vol. 233 Issue 4763, p541; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - NORDAN, RICHARD P.
AU  - POTTER, MICHAEL
T1  - A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro.
JO  - Science
JF  - Science
Y1  - 1986/08//8/1/1986
VL  - 233
IS  - 4763
M3  - Article
SP  - 566
EP  - 569
SN  - 00368075
AB  - Plasmacytoma (PCT) cell lines dependent for proliferation and survival on a factor elaborated by the murine macrophage cell line, P388D1, were established in vitro. Adherent peritoneal cells induced by pristane produced 50-fold greater amounts of this activity in vitro than did resident cells. The molecules responsible for plasmacytoma growth were distinct from a number of characterized factors including interleukin- 1, -2, and -3, macrophage colony-stntilating factor, B-cell stimulatory factor-I, B-cell growth factor II, epidermal growth factor, transforming growth factor-β, and γ- and β-interferon, none of which were able to support the growth of the factordependent PCT cell lines. These results suggest that PCT growth factor may be a novel factor that has not been previously characterized and, further, that its production is associated with the pristane-induced, chronic peritoneal inflammatory response that precedes plasmacytoma formation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519503; NORDAN, RICHARD P. 1 POTTER, MICHAEL 1; Affiliation:  1: Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892; Source Info: 8/1/1986, Vol. 233 Issue 4763, p566; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - OZAWA, KEIYA
AU  - KURTZMAN, GARY
AU  - YOUNG, NEAL
T1  - Replication of the B19 Parvovirus in Human Bone Marrow Cell Cultures.
JO  - Science
JF  - Science
Y1  - 1986/08/22/
VL  - 233
IS  - 4766
M3  - Article
SP  - 883
EP  - 886
SN  - 00368075
AB  - The B19 parvovnrus is responsible for at least three human diseases. The virus was successfillly propagated in suspension cultures of human erythroid bone marrow from patients with hemolytic anemias; release of newly synthesized virus into the supernatants of infected cultures was observed. This culture system allowed study at a molecular level of events associated with the B19 life cycle. The B19 parvovirus replicated through high molecular weight intermediate forms, linked through a terminal hairpin structure. B19 replication in vitro was highly dependent on the erythropoietic content of cultures and on addition of the hormone erythropoietin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87477664; OZAWA, KEIYA 1 KURTZMAN, GARY 1 YOUNG, NEAL 1; Affiliation:  1: Cell Biology Section, Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892; Source Info: 8/22/1986, Vol. 233 Issue 4766, p883; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107000728
T1  - Health promotion and the elderly: why do it and where does it lead? Position paper.
AU  - Williams TF
Y1  - 1986/08/25/
N1  - Accession Number: 107000728. Language: English. Entry Date: 20010209. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128. 
KW  - Health Services for the Aged -- Trends
KW  - Health Policy -- Trends
KW  - Health Promotion -- Trends -- In Old Age
KW  - Health Behavior -- In Old Age
KW  - Aged
SP  - 257
EP  - 262
JO  - Home Health Care Services Quarterly
JF  - Home Health Care Services Quarterly
JA  - HOME HEALTH CARE SERV Q
VL  - 7
IS  - 2
PB  - Taylor & Francis Ltd
SN  - 0162-1424
AD  - Director, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 31, 2C-02, Bethesda, Maryland 20205
U2  - PMID: 10280225.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Longo, Dan L.
T1  - ABC of Nutrition.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/09//
VL  - 44
IS  - 3
M3  - Book Review
SP  - 431
EP  - 432
SN  - 00029165
KW  - Nutrition
KW  - Nonfiction
KW  - Truswell, A. Stewart
KW  - ABC of Nutrition (Book)
N1  - Accession Number: 91271446; Longo, Dan L. 1; Affiliations: 1: National Cancer Institute, Biological Response Modifiers Program, Frederick Cancer Research Facility, Building 567, Room 129, Frederick, MD 21701; Issue Info: Sep1986, Vol. 44 Issue 3, p431; Thesaurus Term: Nutrition; Subject Term: Nonfiction; Reviews & Products: ABC of Nutrition (Book); People: Truswell, A. Stewart; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Henderson, D. K.
AU  - Kan, Virginia L.
AU  - Bennett, J. E.
T1  - Tolerance to cryptococcal polysaccharide in cured cryptococcosis patients: failure of antibody secretion in vitro.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1986/09//
VL  - 65
IS  - 3
M3  - Article
SP  - 639
EP  - 646
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Ten patients cured of cryptococcosis and 14 normal volunteers were immunized with subcutaneous injections of cryptococcal polysaccharide (CPS). Peripheral mononuclear cells cultured from the volunteers 7 days post-immunization secreted significant amounts of 1gM. lgA and IgG antibody to CPS in vitro. In cell cultures obtained 7 days alter immunization of patients, nine of 10 had neither 1gM nor lgG antibody response to CPS. and eight lacked anti-CPS IgA. Depletion of T lymphocytes from patients cell cultures did not promote specific antibody secretion to CPS by B cells. The intense, prolonged antigenaemia with CPS that accompanies cryptococcosis may he responsible for the failure of cured patients to have circulating anti-CPS-secreting cells after immunization. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POLYSACCHARIDES
KW  - TORULOSIS
KW  - CELL culture
KW  - LEUCOCYTES
KW  - T cells
KW  - BIOLOGICAL transport
KW  - cryptococcal polysaccharide
KW  - immunization tolerance
KW  - in vitro antibody production
N1  - Accession Number: 16169116; Henderson, D. K. 1,2 Kan, Virginia L. 2 Bennett, J. E. 2; Affiliation:  1: Hospital Epidemiology Service, National Institutes of Health, Clinical Center, Bethesda, MD.  2: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy, Infections Diseases, Bcthesda, MD, USA.; Source Info: Sep1986, Vol. 65 Issue 3, p639; Subject Term: POLYSACCHARIDES; Subject Term: TORULOSIS; Subject Term: CELL culture; Subject Term: LEUCOCYTES; Subject Term: T cells; Subject Term: BIOLOGICAL transport; Author-Supplied Keyword: cryptococcal polysaccharide; Author-Supplied Keyword: immunization tolerance; Author-Supplied Keyword: in vitro antibody production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fleg, Jerome L.
AU  - Gerstenblith, Gary
T1  - CHF: Reflections on current management of the older patient.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1986/09//
VL  - 41
IS  - 9
M3  - Article
SP  - 71
EP  - 81
SN  - 0016867X
N1  - Accession Number: 17360843; Fleg, Jerome L. 1; Gerstenblith, Gary 2; Source Information: Sep1986, Vol. 41 Issue 9, p71; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 3440
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Zaslow, Martha
AU  - Pedersen, Frank
AU  - Suwalsky, Joan
AU  - Rabinovich, Beth
AU  - Cain, Richard
T1  - Fathering During the Infancy Period: Implications of the Mother's Employment Role.
JO  - Infant Mental Health Journal
JF  - Infant Mental Health Journal
Y1  - 1986///Fall86
VL  - 7
IS  - 3
M3  - Article
SP  - 225
EP  - 234
PB  - John Wiley & Sons, Inc.
SN  - 01639641
AB  - This study addressed fathers' satisfaction with their wives' employment role and fathers' participation in child care and household tasks in a middle-class sample of families with first-born infants in which the mother was either employed or a homemaker. Observations of mother, father, and infant were carried out in the home on weekday evenings when the infants were 12 months old, and parent interviews were carried out after the completion of the observations. On interview measures, fathers with homemaker wives tended to report greater satisfaction with their wives' employment role than did fathers whose wives were employed. In addition, fathers with employed wives, but not those with homemaker wives, reported that they were participating more in child care and household tasks as a result of their wives' employment role. On home observation measures, fathers with employed wives were found to engage in somewhat less Distal Interaction with their infants, but the two groups did not differ with regard to Proximal, Complex Social, or Caregiving Interactions. The results indicate the need to give special consideration to the infancy period when one is examining both paternal endorsement of maternal employment and the father's participation with children in light of the mother's employment role. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Infant Mental Health Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FATHERS
KW  - PARENTING
KW  - WIVES
KW  - EMPLOYMENT (Economic theory)
KW  - MARRIED women -- Employment
KW  - CHILD care
KW  - CHILD rearing
KW  - HOUSEHOLDS
KW  - PARENT & child
KW  - INFANTS
KW  - PARENTHOOD
N1  - Accession Number: 12035160; Zaslow, Martha 1 Pedersen, Frank 1 Suwalsky, Joan 1 Rabinovich, Beth 1 Cain, Richard 1; Affiliation:  1: National Institute of Child Health and Human Development; Source Info: Fall86, Vol. 7 Issue 3, p225; Subject Term: FATHERS; Subject Term: PARENTING; Subject Term: WIVES; Subject Term: EMPLOYMENT (Economic theory); Subject Term: MARRIED women -- Employment; Subject Term: CHILD care; Subject Term: CHILD rearing; Subject Term: HOUSEHOLDS; Subject Term: PARENT & child; Subject Term: INFANTS; Subject Term: PARENTHOOD; NAICS/Industry Codes: 814110 Private Households; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rapoport, Judith L.
AU  - Donnelly, Maureen
AU  - Zametkin, Alan
AU  - Carrougher, John
T1  - 'SITUATIONAL HYPERACTIVITY' IN A U.S. CLINICAL SETTING.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1986/09//
VL  - 27
IS  - 5
M3  - Article
SP  - 639
EP  - 646
SN  - 00219630
AB  - The article focuses on childhood hyperactivity, a major focus of research and clinical attention in the U.S. for the past 25 years. Eight of the 69 males who referred to a Hyperactivity Clinic for participation in psychopharmacological trials were not rated hyperactive by their primary caretaker on a parent symptom questionnaire. In comparison to eight boys for whom both parent and teacher ratings of hyperactivity were high, the group differed only in caretaker status. Situational children were less likely to be living with both biological parents. The findings suggest that at least in clinical settings, a distinction between situational and pervasive hyperactivity reflects caretaker status or attitude and not characteristics of the child.
KW  - CHILD psychology
KW  - HYPERACTIVE children
KW  - PSYCHOLOGY
KW  - PSYCHOPHARMACOLOGY consultation
KW  - GUARDIAN & ward
KW  - FAMILIES
KW  - UNITED States
N1  - Accession Number: 11908069; Rapoport, Judith L. 1 Donnelly, Maureen 1 Zametkin, Alan 1 Carrougher, John 2; Affiliation:  1: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, U.S.A.  2: Uniformed Services School of Health Sciences, Bethesda, Maryland, U.S.A.; Source Info: Sep1986, Vol. 27 Issue 5, p639; Subject Term: CHILD psychology; Subject Term: HYPERACTIVE children; Subject Term: PSYCHOLOGY; Subject Term: PSYCHOPHARMACOLOGY consultation; Subject Term: GUARDIAN & ward; Subject Term: FAMILIES; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-7610.ep11908069
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sigman, Marian
AU  - Mundy, Peter
AU  - Sherman, Tracy
AU  - Ungerer, Judy
T1  - SOCIAL INTERACTIONS OF AUTISTIC, MENTALLY RETARDED AND NORMAL CHILDREN AND THEIR CAREGIVERS.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1986/09//
VL  - 27
IS  - 5
M3  - Article
SP  - 647
EP  - 636
SN  - 00219630
AB  - Social interactions of young autistic children and their caregivers were contrasted to interactions involving normal and mentally retarded controls. The autistic children displayed a much lower frequency of attention sharing behaviors, such as pointing to or showing objects. Alternatively, the autistic children directed as much looking, vocalizing and proximity behaviors toward their caregivers as did the other groups. Thus, although the autistic children did not show a clear lack of responsiveness to their caregivers, they did display a significant deficit in indicating behaviors during child-caregiver interaction.
KW  - SOCIAL interaction
KW  - AUTISTIC children
KW  - CAREGIVERS
KW  - CHILDREN with mental disabilities
KW  - DEVELOPMENTALLY disabled children
KW  - CHILD psychology
N1  - Accession Number: 11908133; Sigman, Marian Mundy, Peter Sherman, Tracy 1 Ungerer, Judy 2; Affiliation:  1: Laboratory of Developmental Psychology, National Institute of Mental Health, Washington DC, U.S.A.  2: Department of Psychology, Macquarie University, New South Wales, Australia.; Source Info: Sep1986, Vol. 27 Issue 5, p647; Subject Term: SOCIAL interaction; Subject Term: AUTISTIC children; Subject Term: CAREGIVERS; Subject Term: CHILDREN with mental disabilities; Subject Term: DEVELOPMENTALLY disabled children; Subject Term: CHILD psychology; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-7610.ep11908133
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mundy, Peter
AU  - Sigman, Marian
AU  - Ungerer, Judy
AU  - Sherman, Tracy
T1  - DEFINING THE SOCIAL DEFICITS OF AUTISM: THE CONTRIBUTION OF NON-VERBAL COMMUNICATION MEASURES.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1986/09//
VL  - 27
IS  - 5
M3  - Article
SP  - 657
EP  - 669
SN  - 00219630
AB  - In this article young autistic children were compared to normal and control samples on measures of non-verbal communication skills and object play skills. Deficits in non-verbal communications indicating behaviors best discriminated the children diagnosed as autistic from the other groups. Although the autistic children also exhibited deficits in object play behavior, these deficits did not add appreciably to the discriminant function based on the non-verbal communication behaviors. These results suggest that a deficit in the development of non-verbal indicating behaviors is a significant characteristic of young children who receive the diagnosis of autism.
KW  - AUTISM
KW  - DIAGNOSIS
KW  - AUTISTIC children
KW  - NONVERBAL communication
KW  - CHILD psychology -- Research
KW  - MENTALLY ill children
KW  - SOCIAL interaction
N1  - Accession Number: 11908196; Mundy, Peter Sigman, Marian Ungerer, Judy 1 Sherman, Tracy 2; Affiliation:  1: Department of Psychology, Macquarie University, New South Wales, Australia.  2: Laboratory of Developmental Psychology, National Institute of Mental Health, Washington DC, U.S.A.; Source Info: Sep1986, Vol. 27 Issue 5, p657; Subject Term: AUTISM; Subject Term: DIAGNOSIS; Subject Term: AUTISTIC children; Subject Term: NONVERBAL communication; Subject Term: CHILD psychology -- Research; Subject Term: MENTALLY ill children; Subject Term: SOCIAL interaction; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1469-7610.ep11908196
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rogan, Walter J.
T1  - Comment.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1986/09//
VL  - 81
IS  - 395
M3  - Article
SP  - 602
SN  - 01621459
AB  - The article comments on childhood leukemia incidence in Woburn, Massachusetts. The Woburn study is one of the few that has shown some disturbance in health of the neighborhood residents. Data for these studies are of three sorts: exposure, outcome, and nuisance variables or potential confounders. The usual confounders, like the usual suspects, can be identified and rounded up. Outcome variables are the illnesses and conditions that the author hopes to attribute to chemical exposures. The major one, childhood leukemia, is ascertained well, and people need have no suspicion that cases either escaped detection or that some cases really have something else. For practical purposes, perinatal deaths are also ascertained fully and remembered well. Amblyopia, impaired vision and strabismus, squint, sometimes including crossed eyes, are heavily dependent for their reporting on degree to which the parents are concerned. Down's syndrome should be reported well, but the significance of this finding rests on three cases in the high exposed group, and so would appear susceptible to chance.
KW  - HAZARDOUS wastes
KW  - LEUKEMIA
KW  - SOLVENTS
KW  - JUVENILE diseases
KW  - PERINATAL death
KW  - HEALTH
KW  - VISION disorders
KW  - WOBURN (Mass.)
KW  - MASSACHUSETTS
KW  - UNITED States
N1  - Accession Number: 4626933; Rogan, Walter J. 1; Affiliations: 1: Medical Officer, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Sep86, Vol. 81 Issue 395, p602; Thesaurus Term: HAZARDOUS wastes; Subject Term: LEUKEMIA; Subject Term: SOLVENTS; Subject Term: JUVENILE diseases; Subject Term: PERINATAL death; Subject Term: HEALTH; Subject Term: VISION disorders; Subject: WOBURN (Mass.); Subject: MASSACHUSETTS; Subject: UNITED States; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Zahn, Theodore P.
AU  - Schooler, Carmi
AU  - Murphy, Dennis L.
T1  - Autonomic Correlates of Sensation Seeking and Monoamine Oxidase Activity: Using Confirmatory Factor Analysis on Psychophysiological Data.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1986/09//
VL  - 23
IS  - 5
M3  - Article
SP  - 521
EP  - 531
SN  - 00485772
AB  - A negative relationship between platelet monoamine oxidase (MAO) activity and Sensation Seeking (SS) has been reported in several studies. This study evaluates the possible contribution of autonomic nervous system (ANS) activity to this relationship. Additionally, confirmatory factor analysis was used to create models of ANS concepts from a larger number of psychophysiological variables. Skin conductance (SC) and heart rate (HR) were recorded from 46 men and 49 women during a two-session protocol that included rest periods, a balloon stress, a series of tones, and two tasks: two-flash threshold and tachistoscopic recognition. Results showed that the best-fitting models for both rest and task periods included concepts of SC base levels ("arousal"), SC Lability, and HR, and were quite similar for men and women. MAO activity correlated positively with SC concepts, most strongly for women. Women showed negative relationships between sensation seeking and both SC arousal and HR concepts. In contrast, men showed evidence of positive relationships between SC concepts and an active life style. The sex differences and response specificity in these relationships make it unlikely that ANS activity mediates the negative MAO-SS relationship. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOAMINE oxidase
KW  - BLOOD platelets
KW  - SENSATION seeking
KW  - AUTONOMIC nervous system
KW  - FACTOR analysis
KW  - HEART beat
N1  - Accession Number: 11026101; Zahn, Theodore P. 1,2 Schooler, Carmi 1 Murphy, Dennis L. 1; Affiliation:  1: National Institute of Mental Health.  2: Laboratory of Psychology and Psychopathology, Bldg. 10, Rm. 4C110, NIH, Bethesda, MD 20892.; Source Info: Sep1986, Vol. 23 Issue 5, p521; Subject Term: MONOAMINE oxidase; Subject Term: BLOOD platelets; Subject Term: SENSATION seeking; Subject Term: AUTONOMIC nervous system; Subject Term: FACTOR analysis; Subject Term: HEART beat; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1469-8986.ep11026101
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaye, Walter H.
AU  - Gwirtsman, Harry E.
AU  - Obarzanek, Eva
AU  - George, Ted
AU  - Jimerson, David C.
AU  - Ebert, Michael H.
T1  - Caloric intake necessary for weight maintenance in anorexia nervosa: nonbulimics require greater caloric intake than bulimics.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/10//
VL  - 44
IS  - 4
M3  - Article
SP  - 435
EP  - 443
SN  - 00029165
AB  - In the past decade, patients with anorexia nervosa have been subdivided by the presence or absence of bingeing-and-purging behavior. Psychologic, physiologic, and premorbid weight differences have also been discovered between these subgroups. We now report that nonbulimic anorectics required 30-50% more caloric intake than bulimic anorectics to maintain a stable weight. This difference in caloric intake was independent of phase of illness; it was present at low weight and at intervals after weight restoration. Subjects were closely supervised on an inpatient hospital ward ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org so that they could not binge or purge. Motor activity did not appear to explain these alterations in caloric requirements. Such differences in caloric intake could be trait related or a consequence of many years of starving or bingeing behavior. These findings are clinically relevant for advising eating disorder patients of caloric requirements necessary to maintain a normal weight. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Anorexia nervosa
KW  - Body weight
KW  - Eating disorders
KW  - Food -- Caloric content
KW  - Body mass index
N1  - Accession Number: 91251607; Kaye, Walter H. 1; Gwirtsman, Harry E. 2; Obarzanek, Eva 2; George, Ted 2; Jimerson, David C. 2; Ebert, Michael H. 3; Affiliations: 1: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD; 3: Department of Psychiatry, Vanderbilt University, Nashville, TN; Issue Info: Oct1986, Vol. 44 Issue 4, p435; Subject Term: Anorexia nervosa; Subject Term: Body weight; Subject Term: Eating disorders; Subject Term: Food -- Caloric content; Subject Term: Body mass index; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Glueck, Charles J.
AU  - Gordon, David J.
AU  - Nelson, J. J.
AU  - Davis, C. E.
AU  - Tyroler, H. Alfred
T1  - Dietary and other correlates of changes in total and low density lipoprotein cholesterol in hypercholesterolemic men: the lipid research clinics coronary primary prevention trial.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/10//
VL  - 44
IS  - 4
M3  - Article
SP  - 489
EP  - 500
SN  - 00029165
AB  - Correlates of changes in total (TOTAL-C) and low density lipoprotein cholesterol (LDL-C) were examined in the 3806 hypercholesterolemic men of the Lipid Research Clinics Coronary Primary Prevention Trial. These correlates included changes in weight, dietary and alcohol intake, plasma glucose and thyroxine, cigarette smoking, packet count, lipid-lowering drugs other than cholestyramine, and antihypertensive drugs. In both placebo plus diet and cholestyramine plus diet treatment groups, decreases in Quetelet index and in saturated fat and cholesterol intake and increases in polyunsaturated fat intake were consistently associated with reductions in TOTAL-C and in LDL-C. In the cholestyramine group, plasma glucose and smoking were predictors of increased TOTAL-C and LDL-C; age and packet count were predictors of decreased TOTAL-C and LDL-C. Diuretic use was associated with increases in TOTAL-C in both groups and with increases in LDL-C in the cholestyramine group. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Hypercholesteremia
KW  - Low density lipoproteins
KW  - Blood lipoproteins
KW  - Hyperlipidemia
KW  - Men
N1  - Accession Number: 91251615; Glueck, Charles J. 1; Gordon, David J. 2; Nelson, J. J. 3; Davis, C. E. 3; Tyroler, H. Alfred 3; Affiliations: 1: General Clinical Research Center, CLINFO Center, and Lipid Research Clinic, University of Cincinnati Medical Center, Cincinnati, OH; 2: Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Diseases, NHLBI, National Institutes of Health, Bethesda, MD; 3: Departments of Biostatistics and Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC; Issue Info: Oct1986, Vol. 44 Issue 4, p489; Subject Term: Hypercholesteremia; Subject Term: Low density lipoproteins; Subject Term: Blood lipoproteins; Subject Term: Hyperlipidemia; Subject Term: Men; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Spirtas, Robert
AU  - Steinberg, Marshall
AU  - Wands, Ralph C.
AU  - Weisburger, Elizabeth K.
T1  - Identification and Classification of Carcinogens: Procedures of the Chemical Substances Threshold Limit Value Committee, ACGIH.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/10//
VL  - 76
IS  - 10
M3  - Article
SP  - 1232
EP  - 1235
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The Chemical Substances Threshold Limit Value Committee of the American Conference of Governmental Industrial Hygienists has refined its procedures for evaluating carcinogens. Types of epidemiologic and toxicologic evidence used are reviewed and a discussion is presented on how the Committee evaluates data on carcinogenicity. Although it has not been conclusively determined whether biological thresholds exist for all types of carcinogens, the Committee will continue to develop guidelines for permissible exposures to carcinogens. The Committee will continue to use the safety factor approach to setting Threshold Limit Values for carcinogens, despite its shortcomings. A compilation has been developed for lists of substances considered to be carcinogenic by several scientific groups. The Committee will use this information to help to identify and classify carcinogens for its evaluation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INDUSTRIAL hygienists
KW  - CARCINOGENS -- Research
KW  - CONFERENCES & conventions
KW  - COMMITTEES
KW  - ASSOCIATIONS, institutions, etc.
KW  - CARCINOGENICITY testing
KW  - THRESHOLD limit values (Industrial toxicology)
KW  - INDUSTRIAL policy
KW  - SAFETY factor in engineering
N1  - Accession Number: 4686805; Spirtas, Robert 1 Steinberg, Marshall 2 Wands, Ralph C. 3 Weisburger, Elizabeth K. 3; Affiliation:  1: National Cancer Institute, Landow Building, Room 4C-16, Bethesda, MD 20892  2: Hazelton Laboratories  3: Ralph C. Wands & Associates, Inc; Source Info: Oct86, Vol. 76 Issue 10, p1232; Subject Term: INDUSTRIAL hygienists; Subject Term: CARCINOGENS -- Research; Subject Term: CONFERENCES & conventions; Subject Term: COMMITTEES; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: CARCINOGENICITY testing; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: INDUSTRIAL policy; Subject Term: SAFETY factor in engineering; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Boyd, Jeffrey H.
AU  - Mościcki, Eve K.
T1  - Firearms and Youth Suicide.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/10//
VL  - 76
IS  - 10
M3  - Article
SP  - 1240
EP  - 1242
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The firearm suicide rate for persons aged 10 to 24 has increased from 2.3 per 100,000 in 1933 to 5.5 per 100,000 in 1982. Over the same period, the suicide rate for this age group by all methods other than firearms has only risen from 2.5 to 3.3. The most dramatic rise in the firearm suicide rate has occurred primarily since 1970, notably among males aged 15 to 24. During the 1960s and 1970s there was a substantial increase in the number of civilian firearms in the United States. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SUICIDE
KW  - FIREARMS
KW  - AGE groups
KW  - MALES
KW  - FIREARMS owners
KW  - FIREARMS ownership
KW  - VIOLENT deaths
KW  - AGE distribution (Demography)
KW  - UNITED States
N1  - Accession Number: 4686817; Boyd, Jeffrey H. 1 Mościcki, Eve K. 1; Affiliation:  1: Epidemiology and Psychopathology Branch, Division of Clinical Research, National Institute of Mental Health; Source Info: Oct86, Vol. 76 Issue 10, p1240; Subject Term: SUICIDE; Subject Term: FIREARMS; Subject Term: AGE groups; Subject Term: MALES; Subject Term: FIREARMS owners; Subject Term: FIREARMS ownership; Subject Term: VIOLENT deaths; Subject Term: AGE distribution (Demography); Subject Term: UNITED States; NAICS/Industry Codes: 332992 Small Arms Ammunition Manufacturing; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 451119 All other sporting goods stores; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bader, Max
AU  - Zhao-Yi Xu
AU  - Blot, William J.
AU  - Fraumeni Jr., Joseph F.
AU  - Chamberlin, Ann N.
AU  - Muller, Andreas
AU  - Jessop, Dorothy Jones
AU  - Newacheck, Paul W.
AU  - Budetti, Peter P.
AU  - Holfon, Neal
T1  - The Smoke-free Hospital, Allentown, PA.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/10//
VL  - 76
IS  - 10
M3  - Article
SP  - 1248
EP  - 1248
PB  - American Public Health Association
SN  - 00900036
AB  - The article reports that HealthEast, the nonprofit parent company of the Allentown Hospital and Lehigh Valley Hospital Center in Pennsylvania, has enacted a no-smoking policy after conducting a smoking cessation program for staff, employees, volunteers and the public. The purpose of HealthEast is to encourage individuals to quit smoking for a smoke-free hospital environment as well as for personal health. The initiative represents the hospital management's commitment to public health. An anti-smoking campaign was introduced after a survey of the 3,500 employees at the two hospitals showed that the majority favored limiting smoking. Another survey will be conducted to measure the success of physicians participating in the no-smoking campaign.
KW  - NONPROFIT organizations
KW  - HOSPITAL management companies
KW  - HOSPITALS
KW  - SMOKING cessation
KW  - NONSMOKING areas
KW  - MEDICAL personnel
KW  - PUBLIC health
KW  - SMOKING
KW  - HEALTH surveys
KW  - PENNSYLVANIA
N1  - Accession Number: 4686833; Bader, Max Zhao-Yi Xu 1 Blot, William J. 2 Fraumeni Jr., Joseph F. 2 Chamberlin, Ann N. 3 Muller, Andreas 4 Jessop, Dorothy Jones 5 Newacheck, Paul W. 6 Budetti, Peter P. 6 Holfon, Neal 6; Affiliation:  1: Liaoning Province Public Health and Anti-Epidemic Station, Shenyang, People's Republic of China.  2: National Cancer Institute, Bethesda, MD 20892.  3: Program Manager, New Hampshire, Child Passenger Safety Program, Dartmouth Medical School, Department of Maternal and Child Health, Hanover, NH 03756.  4: Associate Professor, University of Oklahoma, Health Sciences Center, College of Public Health, Department of Health Administration, P. O. Box 26901, Oklahoma City, OK 73190.  5: Associate Professor of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.  6: Institute for Health Policy Studies, University of California, San Francisco 94143.; Source Info: Oct86, Vol. 76 Issue 10, p1248; Subject Term: NONPROFIT organizations; Subject Term: HOSPITAL management companies; Subject Term: HOSPITALS; Subject Term: SMOKING cessation; Subject Term: NONSMOKING areas; Subject Term: MEDICAL personnel; Subject Term: PUBLIC health; Subject Term: SMOKING; Subject Term: HEALTH surveys; Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 813319 Other Social Advocacy Organizations; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621990 All other ambulatory health care services; Number of Pages: 2/5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Zhao-Yi Xu
AU  - Blot, William J.
AU  - Fraumeni Jr., Joseph F.
T1  - Geographic Variation of Female Lung Cancer in China.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/10//
VL  - 76
IS  - 10
M3  - Letter
SP  - 1249
EP  - 1250
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "Patterns of Site-Specific Displacement in Cancer Mortality Among Migrants: The Chinese in the United States," by H. King, J. Y. Li, F. B. Locke, E. S. Pollack and J. T. Tu in the previous issue.
KW  - LETTERS to the editor
KW  - LUNGS -- Cancer
KW  - CHINESE -- United States
N1  - Accession Number: 21095904; Zhao-Yi Xu 1 Blot, William J. 2 Fraumeni Jr., Joseph F. 2; Affiliation:  1: Liaoning Province Public Health and Anti-Epidemic Station, Shenyang, People's Republic of China  2: National Cancer Institute, Bethesda, MD 2089; Source Info: Oct86, Vol. 76 Issue 10, p1249; Subject Term: LETTERS to the editor; Subject Term: LUNGS -- Cancer; Subject Term: CHINESE -- United States; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Taube, Carl A.
AU  - Schlenger, William E.
AU  - Rupp, Agnes
AU  - Whitmore, Roy W.
T1  - Validity of Medicaid Household Respondent Reporting of Ambulatory Visits for Mental Disorders.
JO  - Journal of Economic & Social Measurement
JF  - Journal of Economic & Social Measurement
Y1  - 1986/10//
VL  - 14
IS  - 3
M3  - Article
SP  - 243
EP  - 256
PB  - IOS Press
SN  - 07479662
AB  - Comparison with administrative records or "best estimate file" enables an evaluation of the accuracy of household reports of mental health use in the four-State Medicaid Household Survey conducted as part of the National Medical Care Utilization and Expenditure Survey. Underreporting of probability of ambulatory mental health use ranged from 14 to 24% compared to 5 to 7% for ambulatory health visits; household estimates of number of mental health visits seemed to be more accurate than administrative records. Household reporting of provider type seemed to be very accurate for psychiatrist visits, but there seemed to be a tendency to report psychologist visits as psychiatrist visits. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAID
KW  - MEDICAL care
KW  - PSYCHOLOGISTS
KW  - MENTAL health
KW  - EVALUATION
KW  - MENTAL illness
KW  - PATHOLOGICAL psychology
KW  - HOUSEHOLD surveys
KW  - MEDICAL care surveys
KW  - PSYCHIATRISTS
N1  - Accession Number: 6644336; Taube, Carl A. 1; Schlenger, William E. 2; Rupp, Agnes 2; Whitmore, Roy W. 2; Affiliations: 1: Acting Director, Division of Biometry and Applied Services, National Institute of Mental Health, U.S. Department of Health and Human Services, Rockville, Maryland 20857; 2: National Institute of Mental Health and Research Triangle Institute; Issue Info: Oct86, Vol. 14 Issue 3, p243; Thesaurus Term: MEDICAID; Thesaurus Term: MEDICAL care; Thesaurus Term: PSYCHOLOGISTS; Subject Term: MENTAL health; Subject Term: EVALUATION; Subject Term: MENTAL illness; Subject Term: PATHOLOGICAL psychology; Subject Term: HOUSEHOLD surveys; Subject Term: MEDICAL care surveys; Subject Term: PSYCHIATRISTS; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Hawley-Nelson, Pamela
AU  - Roop, Dennis R.
AU  - Cheng, Christina K.
AU  - Yuspa, Stuart H.
T1  - Regulated Synthesis of Low-Molecular-Weight Antigens in Keratinocyte Cell Cultures.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/10//
VL  - 87
IS  - 4
M3  - Article
SP  - 454
EP  - 459
SN  - 0022202X
AB  - Proteins from mouse epidermis cytosol extracts react on immunoblots with a polyclonal rabbit antiserum raised against rat skin calcium-binding protein (SCaBP), a parvalbumin of the panniculus carnosus. Three mouse epidermal proteins with molecular weights between 10-12K, which are distinct from SCaBP, are recognized by the antiserum. The synthesis of these proteins in keratinocyte culture is modulated by Ca++, as is the differentiation of the keratinocytes. Proliferating mouse keratinocytes in medium containing 0.07 mM Ca++ (low CaCa++) undergo terminal differentiation when the Ca++ concentration is elevated to 1.8 mM (high Ca++). Synthesis of the 3 antigens can be demonstrated when soluble extracts of keratinocytes labeled with [35S]methionine in low Ca++ medium are immunoprecipitated with anti-SCaBP serum. These antigens are not synthesized in cultures of dermal fibroblasts. When keratinocytes are switched to high Ca++ medium, synthesis of these antigens is greatly diminished over the course of 48-72 h. However, the antigens persist in differentiating cells. When proliferating keratinocytes in low Ca++ medium are exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), differentiation is induced in a subpopulation of cells, and specific antigen synthesis is transiently inhibited. The inhibition correlates with the time when many cells are differentiating in response to TPA. When proliferating keratinocytes are pulse-labeled with 32PO4, the 11 K antigen is phosphorylated and the phosphorylation is not enhanced by TPA exposure. All 3 antigens are synthesized in a reticulocyte lysate preparation with added newborn mouse epidermis messenger RNA or mRNA from keratinocytes cultured in low Ca++ medium. Thus, these antigens are likely to represent unique proteins rather than processed or degraded ones. The coordinately regulated expression of these antigens associated with the differentiation state of the keratinocyte proliferation and differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - LYMPHOMAS
KW  - PROTEINS
KW  - KERATINOCYTES
KW  - EPIDERMIS
KW  - CELLS
N1  - Accession Number: 12455495; Hawley-Nelson, Pamela 1,2 Roop, Dennis R. 1 Cheng, Christina K. 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland  2: Department of Biology, Catholic University of America, Washington. D.C., U.S.A.; Source Info: Oct86, Vol. 87 Issue 4, p454; Subject Term: ANTIGENS; Subject Term: LYMPHOMAS; Subject Term: PROTEINS; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: CELLS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12455495
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DB  - aph
ER  - 

TY  - JOUR
AU  - Backlund Jr., Peter S.
AU  - Carotti, Daniela
AU  - Cantoni, Giulio L.
T1  - Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1986/10/15/
VL  - 160
IS  - 2
M3  - Article
SP  - 245
EP  - 251
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Examines the effects of 3-deazaaristeromycin and 3-deazaadenosine on RNA methylation and synthesis in the mouse macrophage cell line, RAW264.  S-Adenosylhomocysteine accumulated in cells incubated with 3-deazaaristeromycin; Inhibition of messenger RNA synthesis by treatment of cells with 3-deazaadenosine and the inhibition of synthesis was not correlated with an inhibition of methylation.
KW  - MESSENGER RNA
KW  - METHYLATION
KW  - MACROPHAGES
KW  - CELL lines
KW  - ADENOSINE
KW  - MICE as laboratory animals
N1  - Accession Number: 12248600; Backlund Jr., Peter S. 1 Carotti, Daniela 1 Cantoni, Giulio L. 1; Affiliation:  1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda; Source Info: 10/15/86, Vol. 160 Issue 2, p245; Subject Term: MESSENGER RNA; Subject Term: METHYLATION; Subject Term: MACROPHAGES; Subject Term: CELL lines; Subject Term: ADENOSINE; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mendelson, Ella
AU  - Landsma, David
AU  - Druckmann, Shulamit
AU  - Bustin, Michael
T1  - Immunofractionation of chromatin regions associated with histone H1º.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1986/10/15/
VL  - 160
IS  - 2
M3  - Article
SP  - 253
EP  - 260
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Reports on the binding of two monoclonal antibodies, which were elicited against histone H5, to purified rat liver chromatin.  Immobilization of the monoclonal antibodies on CNBr-Sepharose; Use of the resulting immunoaffinity column to fractionate rat liver oligonucleosomes; Examination of DNA purified from the unfractionated nucleosomes, from the unbound nucleosomes and from the nucleosomes which were bound to the column.
KW  - MONOCLONAL antibodies
KW  - HISTONES
KW  - LIVER
KW  - CHROMATIN
KW  - SEPHAROSE
KW  - RATS as laboratory animals
N1  - Accession Number: 12248612; Mendelson, Ella 1 Landsma, David 1 Druckmann, Shulamit 1 Bustin, Michael 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 10/15/86, Vol. 160 Issue 2, p253; Subject Term: MONOCLONAL antibodies; Subject Term: HISTONES; Subject Term: LIVER; Subject Term: CHROMATIN; Subject Term: SEPHAROSE; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shiono, Patricia H.
AU  - Klebanoff, Mark A.
T1  - Ethnic Differences in Preterm and Very Preterm Delivery.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/11//
VL  - 76
IS  - 11
M3  - Article
SP  - 1317
EP  - 1321
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Ethnic differences in preterm (<37 weeks) and very preterm (<33 weeks) delivery were evaluated in a prospective cohort of 28,330 women. Blacks had the highest rate of preterm and very preterm delivery, followed by Mexican-Americans, Asians, and Whites. Adjustment for maternal age, education, marital status, employment, parity, number of previous spontaneous or induced abortions, smoking and drinking during pregnancy, infant sex, and gestational age at initiation of prenatal care resulted in the following odds ratios for preterm delivery: 1.79 (1.55-2.08) for Blacks, 1.40 (1.19-1.63) for Mexican-Americans, 1.40 (1.16-1.69) for Asians, and 1.00 for Whites. The corresponding odds ratios for very preterm delivery were 2.35 (1.72-3.22) for Blacks, 1.31 (0.88-1.94) for Mexican-Americans, 1.10 (0.67-1.83) for Asians, and 1.00 for Whites. Exclusion of cases of premature rupture of membranes, placenta previa, and abruptio placenta did not explain the large ethnic differences. Although Whites and Mexican-Americans had similar birthweight distributions, Mexican-Americans had an increased risk for preterm delivery. Fifty-five per ¢ of low birthweight babies in Kaiser were preterm and this fraction did not vary substantially by ethnic group. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREMATURE labor
KW  - PREMATURE infants
KW  - ETHNICITY
KW  - GRAVID uterus
KW  - PLACENTA
KW  - PAY equity
KW  - INFLUENCE of age on ability
KW  - PREGNANT women
KW  - DURATION of pregnancy
N1  - Accession Number: 4686856; Shiono, Patricia H. 1 Klebanoff, Mark A. 1; Affiliation:  1: National Institute of Health, National Institute of Child Health and Human Development, Epidemiology Biometry Research Program, Landow Building, Room 7c16, Bethesda, MD 20892.; Source Info: Nov86, Vol. 76 Issue 11, p1317; Subject Term: PREMATURE labor; Subject Term: PREMATURE infants; Subject Term: ETHNICITY; Subject Term: GRAVID uterus; Subject Term: PLACENTA; Subject Term: PAY equity; Subject Term: INFLUENCE of age on ability; Subject Term: PREGNANT women; Subject Term: DURATION of pregnancy; Number of Pages: 5p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Moment, Gairdner B.
T1  - BIOLOGY OF GERONTOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1986/11//
VL  - 36
IS  - 10
M3  - Book Review
SP  - 693
EP  - 693
SN  - 00063568
AB  - Reviews the book "The Molecular Biology of Aging," edited by A.D. Woodhead, A.D. Blackett, and A. Hollaender.
KW  - Molecular biology
KW  - Nonfiction
KW  - Molecular Biology of Aging (Book)
N1  - Accession Number: 10114210; Moment, Gairdner B. 1,2; Affiliations: 1: Guest Scientist, National Institute on Aging; 2: Professor Emeritus of Biology, Goucher College, Baltimore, MD 21204; Issue Info: Nov86, Vol. 36 Issue 10, p693; Thesaurus Term: Molecular biology; Subject Term: Nonfiction; Reviews & Products: Molecular Biology of Aging (Book); Number of Pages: 8/9p; Document Type: Book Review; Full Text Word Count: 832
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ER  - 

TY  - JOUR
AU  - Elgjo, Kjell
AU  - Reichelt, Karl L.
AU  - Hennings, Henry
AU  - Michael, Delores
AU  - Yuspa, Stuart H.
T1  - Purified Epidermal Pentapeptide Inhibits Proliferation and Enhances Terminal Differentiation in Cultured Mouse Epidermal Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1986/11//
VL  - 87
IS  - 5
M3  - Article
SP  - 555
EP  - 558
SN  - 0022202X
AB  - Skin extracts contain an epidermal mitosis inhibitor that recently has been purified and identified as a pentapeptide. To develop an in vitro assay system for further biologic characterization, primary mouse epidermal cells and an established mouse epidermal cell line (line 308) were used for testing of the purified pentapeptide. In primary cell cultures the mitotic activity, as estimated by means of vinblastine, was reversibly inhibited by 44% at a peptide concentration of 10-8 M in high-calcium (1.2 mM Ca++), and by 27-38% at peptide concentrations of 10-10 and 10-8 M in low-calcium (0.02 mM Ca++) medium. The 308 cells were inhibited by 46% at a peptide concentration of 10-6 M but only after the cells had reached near-confluence and had a moderate rate of proliferation. A low concentration of adrenalin (0.18 μg/ml) in the medium rendered the primary cultures more sensitive to the peptide. After repeated peptide treatments over 24 h, the number of cornified envelopes (a marker of terminal differentiation) was increased both in primary cultures and in the 308 cells. The epidermal pentapeptide thus seems to influence both proliferation and terminal differentiation in cultured mouse epidermal cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMIS
KW  - CELLS
KW  - PEPTIDES
KW  - CELL proliferation
KW  - CELL culture
KW  - CELL differentiation
N1  - Accession Number: 12455733; Elgjo, Kjell 1 Reichelt, Karl L. 2 Hennings, Henry 3 Michael, Delores 3 Yuspa, Stuart H. 3; Affiliation:  1: Institute of Pathology, Rikshospitalet, Oslo, Norway.  2: Pediatric Research Institute, Rikshospitalet, Oslo, Norway.  3: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Nov86, Vol. 87 Issue 5, p555; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: PEPTIDES; Subject Term: CELL proliferation; Subject Term: CELL culture; Subject Term: CELL differentiation; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12455733
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DB  - aph
ER  - 

TY  - JOUR
AU  - Krichevsky, Micah I.
AU  - Krasse, Bo
T1  - Considerations and conclusions.
JO  - Oral Microbiology & Immunology
JF  - Oral Microbiology & Immunology
Y1  - 1986/11//
VL  - 1
IS  - 1
M3  - Article
SP  - 87
EP  - 91
SN  - 09020055
AB  - Diagnostic microbiological methods play an ever greater role in epidemiological studies and clinical trials related to dental caries and periodontal diseases. Further, such methods can serve the clinician as valuable adjuncts to case history and clinical examination for diagnosis, treatment, and prevention of disease. A variety of diagnostic methods are becoming available and show promise in the hands of individual investigators and clinicians. The further development of diagnostic microbiological methods will require collaborative studies with careful consideration of basic ecological and epidemiological principles as well as modern technology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oral Microbiology & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epidemiology
KW  - Technology
KW  - Dental caries
KW  - Periodontal disease
KW  - Periodontal disease -- Prevention
KW  - Dental pathology
N1  - Accession Number: 12547361; Krichevsky, Micah I. 1; Krasse, Bo 2; Affiliations: 1: Microbial Systematics Section 1, Epidemiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.; 2: Disease Prevention Branch, Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.; Issue Info: Nov1986, Vol. 1 Issue 1, p87; Thesaurus Term: Epidemiology; Thesaurus Term: Technology; Subject Term: Dental caries; Subject Term: Periodontal disease; Subject Term: Periodontal disease -- Prevention; Subject Term: Dental pathology; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1399-302X.ep12547361
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ER  - 

TY  - JOUR
AU  - QUINN, THOMAS C.
AU  - MANN, JONATHAN M.
AU  - CURRAN, JAMES W.
AU  - PIOT, PETER
T1  - AIDS in Africa: An Epidemiologic Paradigm.
JO  - Science
JF  - Science
Y1  - 1986/11/21/
VL  - 234
IS  - 4779
M3  - Article
SP  - 955
EP  - 963
SN  - 00368075
AB  - Cases of the acquired immune deficiency syndrome (AIDS) have been reported in countries throughout the world. Initial surveillance studies in Central Africa suggest an annual incidence of AIDS of 550 to 1000 cases per million adults. The male to female ratio of cases is 1:1, with age- and sex-specific rates greater in females less than 30 years of age and greater in males over age 40. Clinically, AIDS in Africans is often characterized by a diarrhea-wasting syndrome, opportunistic infections, such as tuberculosis, cryptococcosis, and cryptosporidiosis, or disseminated Kaposi's sarcoma. From 1 to 18% of healthy blood donors and pregnant women and as many as 27 to 88% of female prostitutes have antibodies to human immunodeficiency virus (HIV). The present annual incidence of infection is approximately 0.75% among the general population of Central and East Africa. The disease is transmitted predominately by heterosexual activity, parenteral exposure to blood transfusions and unsterilized needles, and perinatally from infected mothers to their newborns, and will continue to spread rapidly where economic and cultural factors favor these modes of transmission. Prevention and control of HIV infection through educational programs and blood bank screening should be an immediate public health priority for all African countries. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692402; QUINN, THOMAS C. 1,2 MANN, JONATHAN M. 3 CURRAN, JAMES W. 4 PIOT, PETER 5; Affiliation:  1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892  2: Johns Hopkins University School of Medicine, Baltimore, MD 21205  3: Control Prograr on AIDS, World Health OrgLanution, 1211 Geneva 27, Switzerland  4: AIDS Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 30333  5: Department of Microbiology, Institute of Tropical Medicine, B-2000 Antwerp, Belgium; Source Info: 11/21/1986, Vol. 234 Issue 4779, p955; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KOZEL, NICHOLAS J.
AU  - ADAMS, EDGAR H.
T1  - Epidemiology of Drug Abuse: An Overview.
JO  - Science
JF  - Science
Y1  - 1986/11/21/
VL  - 234
IS  - 4779
M3  - Article
SP  - 970
EP  - 974
SN  - 00368075
AB  - Issues regarding the use of epidemiology in drug abuse research are discussed and systems for monitoring national trends and identifying risk factors are described. Data indicate a general decline in marijuana use among youth, a cohort aging effect among heroin and marijuana users, and increased prevalence and health consequences associated with cocaine use. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692404; KOZEL, NICHOLAS J. 1 ADAMS, EDGAR H. 1; Affiliation:  1: Division of Epidemiology and Statistical Analysis, National Institute on Drug Abuse, Rockville, MD 20857; Source Info: 11/21/1986, Vol. 234 Issue 4779, p970; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - WRIGHT, CONNIE M.
AU  - FELBER, BARBARA K.
AU  - PASKALIS, HARRY
AU  - PAVLAKIS, GEORGE N.
T1  - Expression and Characterization of the Trans- Activator of HTLV-III/LAV Virus.
JO  - Science
JF  - Science
Y1  - 1986/11/21/
VL  - 234
IS  - 4779
M3  - Article
SP  - 988
EP  - 992
SN  - 00368075
AB  - The human T-lymphotropic retrovirus HTLV-III/LAV encodes a trans-activator that increases viral gene expression. We expressed this trans-activator in animal cells and studied its structural and functional characteristics. The putative trans-activator protein was immunoprecipitated from overproducing stable cell lines and shown to migrate as a 14-kilodalton polypeptide on sodium dodecyl sulfate-polyacrylamide gels. S1 nuclease mapping experiments showed that the trans-activator increases the levels of steady-state messenger RNA transcribed from the viral long terminal repeat promoter. Sequences within the R region of the HTLV-III/LAV long terminal repeat are essential for trans-activation. Quantitations of messenger RNA and protein showed that the protein increase was greater than the messenger RNA increase in CV1 and HeLa cells, indicating that more than one mechanism was responsible for the. trans--activation and that cell type-specific factors may determine the final level of trans-activation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692409; WRIGHT, CONNIE M. 1,2 FELBER, BARBARA K. 1 PASKALIS, HARRY 1 PAVLAKIS, GEORGE N. 1; Affiliation:  1: Bionetics Research, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD 21701  2: Department of Biology, University of Maryland, Baltimore County, Catonsville, MD 21228; Source Info: 11/21/1986, Vol. 234 Issue 4779, p988; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - FURANo, ANTHONY V.
AU  - OWENS, GR$LGORY P.
AU  - CHAUDHARI, NIRUPA
AU  - HAHN, WILLILA?M E.
T1  - Brain "Identifier Sequence".
JO  - Science
JF  - Science
Y1  - 1986/11/21/
VL  - 234
IS  - 4779
M3  - Article
SP  - 1005
EP  - 1006
SN  - 00368075
N1  - Accession Number: 84692414; FURANo, ANTHONY V. 1 OWENS, GR$LGORY P. 2 CHAUDHARI, NIRUPA 2 HAHN, WILLILA?M E. 2; Affiliation:  1: National Institute of Diabetes and D,qestive and Kidney Diseases, National Institutes of Health, Building 8, Room 203, Bethesda, MD 20892  2: Department of Celular and Structural Biology, University of Colorado School of Medicine, Denver, CO 80262; Source Info: 11/21/1986, Vol. 234 Issue 4779, p1005; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BLACK, SIMON
T1  - Reversible Interconversion of Two Forms of a Valyl-tRNA Synthetase-Containing Protein Complex.
JO  - Science
JF  - Science
Y1  - 1986/11/28/
VL  - 234
IS  - 4780
M3  - Article
SP  - 1111
EP  - 1114
SN  - 00368075
AB  - When an enzyme-containing complex from yeast was incubated in a buffered solutiop at room temperature, the valyl-transfer JLNA synthetase activity and total protein oscillated synchronously between two physical states. This observation suggests a regulatory process that. controls a number of enzymes as a group, an integrated function of a kind not heretofore recognized. The two forms of the complex were separated by anmnonium sulfate precipitation of one of them in samples withdrawn from the incubated solution every 30 seconds. Glutathione and dithiothreitol in high concentrations (50 mM) enhance formation of the 50% saturated ammonium sulfatesoluble form. Oxidized glutathione, diphosphopyridine nudeotide, triphosphopyriI dine nucleotide, and a mercurial thiol binding agent in moderate concentrations (0.1 to 1.0 mM) shift the distribution toward the precipitable forn. It is suggested that the two forms represent functional and nonfimctional complex-bound enzymes which are interconverted in response to oxidoreductive signals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692452; BLACK, SIMON 1; Affiliation:  1: Section on Pharmacology, Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892; Source Info: 11/28/1986, Vol. 234 Issue 4780, p1111; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HUANG, MING-TA
AU  - VEVCH, RICHARD L.
AU  - NELSON, THOMAS
AU  - DIENEL, GERALD
AU  - SOKOLOFF, LOUIS
T1  - Glucose-6-Phosphatase Activity in Brain.
JO  - Science
JF  - Science
Y1  - 1986/11/28/
VL  - 234
IS  - 4780
M3  - Article
SP  - 1128
EP  - 1129
SN  - 00368075
N1  - Accession Number: 84692457; HUANG, MING-TA 1 VEVCH, RICHARD L. 1 NELSON, THOMAS 2 DIENEL, GERALD 2 SOKOLOFF, LOUIS 2; Affiliation:  1: Laboratory of Metabolism, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, 20852  2: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, 20892; Source Info: 11/28/1986, Vol. 234 Issue 4780, p1128; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Micozzi, Marc S.
AU  - Albanes, Demetrius
AU  - Jones, D. Yvonne
AU  - Chumlea, W. Cameron
T1  - Correlations of body mass indices with weight, stature, and body composition in men and women in NHANES I and II.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/12//
VL  - 44
IS  - 6
M3  - Article
SP  - 725
EP  - 731
SN  - 00029165
AB  - It is useful to develop indices of weight and stature, or body mass indices (BMIs), that are highly correlated with weight, are independent of stature,and accurately reflect body composition. The anthropometric data collected in the NHANES I (1971-74) and NHANES II (1976-80) US population samples were used to test the statistical characteristics and biologic correlations of various BMIs reported in the literature. BMIs that are independent of stature and still highly correlated to weight (r = 0.89-0.98) over all ages and distributions of fatness and leanness are W/S² in men and both W/S and W/S1.5 in women. These BMIs are also highly correlated to measured and calculated estimates of body composition including subscapular skinfold thickness (r = 0.78-0.80), arm circumference (r = 0.83-0.89), and arm fat area (r = 0.71-0.83). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Body weight
KW  - Body mass index
KW  - Human body composition
KW  - Men
KW  - Women
KW  - body composition
KW  - body mass index
KW  - body size
KW  - obesity
KW  - stature
KW  - Weight
N1  - Accession Number: 90726550; Micozzi, Marc S. 1; Albanes, Demetrius 1; Jones, D. Yvonne 1; Chumlea, W. Cameron 2; Affiliations: 1: National Cancer Institute, NIH, Bethesda, MD; 2: Department of Pediatrics, Wright State University School of Medicine, Dayton, OH; Issue Info: Dec1986, Vol. 44 Issue 6, p725; Subject Term: Body weight; Subject Term: Body mass index; Subject Term: Human body composition; Subject Term: Men; Subject Term: Women; Author-Supplied Keyword: body composition; Author-Supplied Keyword: body mass index; Author-Supplied Keyword: body size; Author-Supplied Keyword: obesity; Author-Supplied Keyword: stature; Author-Supplied Keyword: Weight; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Reddy, Vinodini
AU  - Bhaskaram, P.
AU  - Raghuramulu, N.
AU  - Milton, Roy C.
AU  - Rao, Vithal
AU  - Madhusudan, J.
AU  - Radha Krishna, K. V.
T1  - Relationship between measles, malnutrition, and blindness: a prospective study in Indian children.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1986/12//
VL  - 44
IS  - 6
M3  - Article
SP  - 924
EP  - 930
SN  - 00029165
AB  - A prospective study was conducted in slum children to determine the incidence of post-measles corneal disease and to clarify its relationship with nutritional status. A total of 318 cases of measles were identified over a period of 15 mo; maximum incidence was observed for children between 1-2 yr. Most of the children showed weight loss and serum proteins decrease during the acute stage of measles. Corneal lesions were observed in 3% of the children, and the lesions responded well to treatment. Serum vitamin A and RBP levels were significantly depressed during the acute stage of measles but were restored to normal 8 wk after recovery. There were no significant differences in the serum levels for those with and without eye lesions, which suggests that these lesions may not be mediated simply through the effect of infection on serum concentration of vitamin A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Virus diseases
KW  - Measles
KW  - Malnutrition
KW  - Nutrition disorders
KW  - Blindness
KW  - blindness
KW  - malnutrition
N1  - Accession Number: 90726573; Reddy, Vinodini 1; Bhaskaram, P. 1; Raghuramulu, N. 1; Milton, Roy C. 2; Rao, Vithal 1; Madhusudan, J. 1; Radha Krishna, K. V. 1; Affiliations: 1: National Institute of Nutrition, Hyderabad, India; 2: National Eye Institute, Bethesda, MD; Issue Info: Dec1986, Vol. 44 Issue 6, p924; Thesaurus Term: Virus diseases; Subject Term: Measles; Subject Term: Malnutrition; Subject Term: Nutrition disorders; Subject Term: Blindness; Author-Supplied Keyword: blindness; Author-Supplied Keyword: malnutrition; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Maynard, Charles
AU  - Fisher, Lloyd D.
AU  - Passamani, Eugene R.
AU  - Pullum, Thomas
T1  - Blacks in the Coronary Artery Surgery Study (CASS): Race and Clinical Decision Making .
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/12//
VL  - 76
IS  - 12
M3  - Article
SP  - 1446
EP  - 1448
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: For patients enrolled in the Coronary Artery Surgery Study (CASS), surgery was recommended for 46.5 per ¢ of Blacks and 59.4 per ¢ of Whites, despite similar clinical and angiographic characteristics. Of those recommended, 80.5 per ¢ of Blacks and 90.4 per ¢ of Whites had bypass surgery. These differences were most apparent for Black laborers. Overall, only 38.0 per ¢ of Blacks had coronary artery bypass surgery, whereas 58.4 per ¢ of Whites received surgery. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORONARY artery bypass
KW  - CORONARY arteries -- Surgery
KW  - HEALTH behavior
KW  - HEALTH & race
KW  - HUMAN behavior
KW  - MEDICAL anthropology
KW  - AFRICAN Americans
KW  - DECISION making
KW  - UNITED States
N1  - Accession Number: 4693464; Maynard, Charles 1 Fisher, Lloyd D. 1 Passamani, Eugene R. 1 Pullum, Thomas 2; Affiliation:  1: Departments of Biostatistics and Sociology, University of Washington, Seattle  2: National Heart, Lung, and Blood Institute, Bethesda, MD; Source Info: Dec1986, Vol. 76 Issue 12, p1446; Subject Term: CORONARY artery bypass; Subject Term: CORONARY arteries -- Surgery; Subject Term: HEALTH behavior; Subject Term: HEALTH & race; Subject Term: HUMAN behavior; Subject Term: MEDICAL anthropology; Subject Term: AFRICAN Americans; Subject Term: DECISION making; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Mackintosh, Douglas
AU  - Mundey, Lynette
AU  - Fischer, Glen
AU  - Morgan, Edward
T1  - Condom Usage by IV Drug Users.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1986/12//
VL  - 76
IS  - 12
M3  - Letter
SP  - 1460
EP  - 1460
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article in the previous issue that involves the contraceptive practices among female drug users.
KW  - LETTERS to the editor
KW  - CONTRACEPTIVES
N1  - Accession Number: 21085071; Mackintosh, Douglas 1 Mundey, Lynette 1 Fischer, Glen 2 Morgan, Edward 3; Affiliation:  1: Vice President, Chief Medical Officer National Capitol Systems, Inc., Falls Church, VA 22041  2: AIDS/Drug Abuse Consultant, Richmond, VA  3: Training and Education Advisor, National Institute on Drug Abuse, Rockville, MD; Source Info: Dec1986, Vol. 76 Issue 12, p1460; Subject Term: LETTERS to the editor; Subject Term: CONTRACEPTIVES; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; Number of Pages: 4/9p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoel, D. G.
AU  - Yanagawa, T.
T1  - Incorporating Historical Controls in Testing for a Trend in Proportions.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1986/12//
VL  - 81
IS  - 396
M3  - Article
SP  - 1095
SN  - 01621459
AB  - The testing of chemicals for carcinogenic activity in lifetime rodent bioassays has produced a large amount of data on a few strains of mice and rats. Because of the use of fixed protocols in repeated experiments, the opportunity presents itself for using this historical data in the analysis of a current experiment. What has been considered is the statistical incorporation of the historical control data into the current control group to increase the power of the test. This is especially relevant when dealing with tumors of a rare type where the toxicologist will place great significance on their occurrence in a treatment group.  Experimentally it is assumed that three groups of about 50 animals each are tested at two treatment levels and a control The response for each treatment group is assumed to be binomial. Further it is assumed that the probability of an animal with a tumor in the control group has a beta distribution that is determined from the historical control data.  Several authors (Dempster, Selwyn, and Weeks 1983; Hoel 1983; Tarone 1982) have investigated the problem of testing for linear trend in proportions when historical information is available. In this article we give a locally most powerful test of trend for binomial response data by using a beta prior distribution for the historical control information. This generalized test is closely related to Tarone's statistic and generalizes the conditional test of Hoel. Under various conditions on the beta parameters (alpha, beta), the asymptotic distribution of the test statistic is given under the null hypothesis Ho of no trend in proportions and for a general sequence of alternative hypotheses that converge to Ho. Using these results, the asymptotic gain due to the incorporation of historical controls is given For the usual bioassay design the... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICAL hypothesis testing
KW  - LINEAR models (Statistics)
KW  - PROBABILITY theory
KW  - BIOLOGICAL assay
KW  - CARCINOGENICITY testing
KW  - RODENTS
KW  - ASYMPTOTIC theory
KW  - CARCINOGENESIS
KW  - TOXICOLOGISTS
KW  - TUMORS
KW  - Beta-binomial distribution.
KW  - Carcinogenesis
KW  - Dichotomous data
KW  - Linear trend
N1  - Accession Number: 4612673; Hoel, D. G. 1; Yanagawa, T. 2,3; Affiliations: 1: Program Director, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; 2: Visiting Scientist, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; 3: Assistant Professor, Department of Mathematics, Kyushu University 33, Fukuoka 812, Japan.; Issue Info: Dec86, Vol. 81 Issue 396, p1095; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: PROBABILITY theory; Subject Term: BIOLOGICAL assay; Subject Term: CARCINOGENICITY testing; Subject Term: RODENTS; Subject Term: ASYMPTOTIC theory; Subject Term: CARCINOGENESIS; Subject Term: TOXICOLOGISTS; Subject Term: TUMORS; Author-Supplied Keyword: Beta-binomial distribution.; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Dichotomous data; Author-Supplied Keyword: Linear trend; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-06431-030
AN  - 2006-06431-030
AU  - Wolfe, Barry E.
T1  - Sing the Body Eclectic.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1986/12//
VL  - 31
IS  - 12
SP  - 975
EP  - 976
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06431-030. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wolfe, Barry E.; Affective and Anxiety Disorders Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Eclectic Psychotherapy; Gestalt Therapy; Psychotherapy. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Smith, Edward W. L. The Body in Psychotherapy=Jefferson, NC: McFarland, 1985. 198 pp. $18.95; 1985. Page Count: 2. Issue Publication Date: Dec, 1986. 
AB  - Reviews the book, The Body in Psychotherapy by Edward W. L. Smith (see record [rid]2001-16811-000[/rid]). In Smith's new book the ecstatic has been exchanged for the eclectic. The result is an intriguing, surprisingly well-specified, integrated approach to psychotherapy. Smith integrates a number of body therapies, including bioenergetics, psychomotor therapy, Brown's organismic psychotherapy, Kelley's Radix, and Reich's orgonomy. These body therapies are, in turn, integrated with the theory and techniques of Gestalt therapy. Smith's concept of normal functioning is based on need satisfaction. What Smith sets out to do he does well. The difficulties with this book concern mainly what Smith did not undertake. A second difficulty involves Smith's system of categorization. A final problem inheres in all bodily oriented approaches to psychotherapy--the relative deemphasis of interpersonal issues in the generation and maintenance of psychopathology. By and large, however, this is a lucid presentation of a typically lubricious topic. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - body therapies
KW  - body eclectic
KW  - psychotherapy
KW  - bioenergetics
KW  - psychomotor therapy
KW  - organismic psychotherapy
KW  - Radix
KW  - orgonomy
KW  - Gestalt therapy
KW  - 1986
KW  - Eclectic Psychotherapy
KW  - Gestalt Therapy
KW  - Psychotherapy
KW  - 1986
U2  - Smith, Edward W. L. (1985); The Body in Psychotherapy; Jefferson, NC: McFarland, 1985. 198 pp. $18.95
DO  - 10.1037/024337
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - SUZDAK, PETER D.
AU  - GLOWA, JOHN R.
AU  - CRAWLEY, JACQUELINE N.
AU  - SCHWARTZ, ROCHELLE D.
AU  - SKOLNICK, PHIL
AU  - PAUL, STEVEN M.
T1  - A Selective Imidazobenzodiazepine Antagonist of Ethanol in the Rat.
JO  - Science
JF  - Science
Y1  - 1986/12/05/
VL  - 234
IS  - 4781
M3  - Article
SP  - 1243
EP  - 1247
SN  - 00368075
AB  - Ethanol, at pharmacologically relevant concentrations of 20 to 100 mM, stimulates 'yaminobutyric (GABA) receptor-mediated uptake of 36Cl-labeled chlorine into isolated brain vesicles. One drug that acts at GABA-benzodiazepine receptors, the imidazobenzodiazepine Ro15-4513, has been found to be a potent antagonist of ethanolstimulated 36C1- uptake into brain vesicles, but it fails to antagonize either pentobarbital- or muscimol-stimulated 36Cl- uptake. Pretreatment of rats with Ro15-4513 blocks the anticonflict activity oflow doses ofethanol (but not pentobarbital) as well as the behavioral intoxication observed with higher doses of ethanol. The effects of Rol5- 4513 in antagonizing ethanol-stimulated 36C1- uptake and behavior are completely blocked by benzodiazepine receptor antagonists. However, other benzodiazepine receptor inverse agonists fail to antagonize the actions of ethanol in vitro or in vivo, suggesting a novel interaction of Rol5-4513 with the GABA receptor-coupled chloride ion channel complex. The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions of ethanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460414; SUZDAK, PETER D. 1 GLOWA, JOHN R. 1 CRAWLEY, JACQUELINE N. 1 SCHWARTZ, ROCHELLE D. 1 SKOLNICK, PHIL 2 PAUL, STEVEN M. 1; Affiliation:  1: Section on Molecular Pharmacology and Preclinical Studies, Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892  2: Section on Neurobiology, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Heath, Bethesda, MD 20892; Source Info: 12/5/1986, Vol. 234 Issue 4781, p1243; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ziegler, Regina G.
AU  - Wilcox III, Homer B.
AU  - Mason, Thomas J.
AU  - Bill, Joanne S.
AU  - Virgo, Phillip W.
T1  - Seasonal variation in intake of carotenoids and vegetables and fruits among white men in New Jersey.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/01//
VL  - 45
IS  - 1
M3  - Article
SP  - 107
EP  - 114
SN  - 00029165
AB  - In a population-based case-control study of lung cancer among New Jersey men, usual adult consumption of many vegetables and fruits was included in the interview to assess the protective potential of carotenoids. With data from 900 controls the percentage of New Jersey white men who eat specific vegetables and fruits primarily in certain seasons, the relative importance of in-season and out-of-season consumption, and the median length of season were determined. Although first asking whether a food item was consumed all-year-round or primarily in certain seasons and then asking for the appropriate frequency of consumption facilitated the interview, obtaining out-of-season frequency of consumption and length of season was not necessary. Substituting 0 for reported out-of-season frequencies and 3 mo for reported season lengths reduced slightly the observed associations between diet and lung cancer risk but did not modify the overall pattern noted. Carotenoid intake in winter-fall was estimated to be about two-thirds that in summer-spring. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Vegetables
KW  - Fruit
KW  - Carotenoids
KW  - Biological pigments
KW  - New Jersey
KW  - Cancer
KW  - carotenoids
KW  - fruit
KW  - lung
KW  - seasonal
KW  - vegetables
N1  - Accession Number: 91095754; Ziegler, Regina G. 1,2,3; Wilcox III, Homer B. 1,2,3; Mason, Thomas J. 1,2,3; Bill, Joanne S. 1,2,3; Virgo, Phillip W. 1,2,3; Affiliations: 1: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD; 2: Cancer Epidemiology Services, New Jersey State Department of Health, Trenton, NJ; 3: ORI, Inc, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p107; Thesaurus Term: Vegetables; Thesaurus Term: Fruit; Subject Term: Carotenoids; Subject Term: Biological pigments; Subject: New Jersey; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: carotenoids; Author-Supplied Keyword: fruit; Author-Supplied Keyword: lung; Author-Supplied Keyword: seasonal; Author-Supplied Keyword: vegetables; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Donato, Karen A.
T1  - Efficiency and utilization of various energy sources for growth.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/01//
VL  - 45
IS  - 1
M3  - Article
SP  - 164
EP  - 167
SN  - 00029165
AB  - The article focuses on a study which investigates the efficiency of use of energy sources in animals and human subjects based on comparing the metabolic effects, such as growth, fat deposition, and protein deposition. Topics include explanations for energy concepts, increased efficiency of energy utilization from fat during growth.
KW  - Energy consumption
KW  - Fats & oils
KW  - Food -- Fat content
KW  - Food -- Protein content
KW  - Diet
N1  - Accession Number: 91095765; Donato, Karen A. 1; Affiliations: 1: Nutrition Coordinating Committee, National Institutes of Health, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p164; Thesaurus Term: Energy consumption; Subject Term: Fats & oils; Subject Term: Food -- Fat content; Subject Term: Food -- Protein content; Subject Term: Diet; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Poirier, Lionel A.
T1  - Stages in carcinogenesis: alteration by diet.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/01//
VL  - 45
IS  - 1
M3  - Article
SP  - 185
EP  - 191
SN  - 00029165
AB  - The article focuses on the stages of chemical carcinogenesis which includes carcinogen metabolism, initiation and promotion and tumor cell progression, and tumor growth and development. The first set of stages is based upon he electrophilic hypothesis of carcinogenesis, second stage offers distinction between initiation and promotion and the promotion stage shows formation of follicular carcinomas in the thyroid gland of methylnitrosourea-iitiated rats fed an iodine-deficient diet.
KW  - Carcinogenesis
KW  - Malnutrition
KW  - Thyroid gland
KW  - Food habits
KW  - Metabolism
N1  - Accession Number: 91095768; Poirier, Lionel A. 1; Affiliations: 1: Nutrition and Metabolism Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p185; Thesaurus Term: Carcinogenesis; Subject Term: Malnutrition; Subject Term: Thyroid gland; Subject Term: Food habits; Subject Term: Metabolism; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Simopoulos, Artemis P.
T1  - Obesity and carcinogenesis: historical perspective.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/01//
VL  - 45
IS  - 1
M3  - Article
SP  - 271
EP  - 276
SN  - 00029165
AB  - The article offers information on a study which shows the association of obesity with reduced life expectancy. Topics include major causes of excess cancer mortality among women, association between overweight and cancer of the breast and endometrium and relationship of obesity to cardiovascular disease.
KW  - Carcinogenesis
KW  - Obesity
KW  - Life expectancy
KW  - Weight loss
KW  - Nutrition disorders
N1  - Accession Number: 91095782; Simopoulos, Artemis P. 1; Affiliations: 1: Nutrition Coordinating Committee, National Institutes of Health, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p271; Thesaurus Term: Carcinogenesis; Subject Term: Obesity; Subject Term: Life expectancy; Subject Term: Weight loss; Subject Term: Nutrition disorders; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Greenwald, Peter
AU  - Clifford, Carolyn
AU  - Butrum, Ritva R.
AU  - Iverson, Donald C.
T1  - Feasibility studies of a low-fat diet to prevent or retard breast cancer.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/01//
VL  - 45
IS  - 1
M3  - Article
SP  - 347
EP  - 353
SN  - 00029165
AB  - The article focuses on a study that determine whether low-fat diets can reduce the incidence of breast cancer in high-risk women or reduce the likelihood of recurrence of breast cancer in women. Topics include importance of randomized controlled intervention trials, dietary fat as a risk factor for breast cancer and low-fat trial in relation with other adjuvant medical therapy.
KW  - Carcinogens
KW  - Fat
KW  - Lipids
KW  - Breast cancer
KW  - Tumors
N1  - Accession Number: 91095795; Greenwald, Peter 1; Clifford, Carolyn 1; Butrum, Ritva R. 1; Iverson, Donald C. 1; Affiliations: 1: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p347; Thesaurus Term: Carcinogens; Subject Term: Fat; Subject Term: Lipids; Subject Term: Breast cancer; Subject Term: Tumors; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kessler, Larry G.
AU  - Burns, Barbara J.
AU  - Shapiro, Sam
AU  - Tischler, Gary L.
AU  - George, Linda K.
AU  - Hough, Richard L.
AU  - Bodison, Dorothea
AU  - Miller, Richard H.
T1  - Psychiatric Diagnoses of Medical Service Users: Evidence from the Epidemiologic Catchment Area Program.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/01//
VL  - 77
IS  - 1
M3  - Article
SP  - 18
EP  - 24
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Based on data from the live sites of the National Institute of Mental Health-sponsored Epidemiologic Catchment Area (ECA) Program this paper examines the prevalence of psychiatric disorder among recent medical service users versus nonusers, with a particular focus on affective disorders, substance abuse/dependence, and phobias. The rate of current Diagnostic Interview Schedule (DIS) disorders among medical users in all five ECA sites is 21.7 per ¢ (slightly higher than general population rates) versus 16.7 per ¢ among nonusers: there is generally no difference between users and nonusers with past DIS diagnoses. Affective disorders were among the most common mental disorders of medical service users, especially among females, with little variation between sites: females: users: 6.9 per ¢ to 9.3 per ¢, nonusers: 3.4 per ¢ to 6.4 per ¢ and males: users: 3.3 per ¢ to 6.5 per ¢. nonusers: 1.2 per ¢ to 4.1 per ¢. Rates of phobia,, among persons using medical services are also higher than among nonusers. Substance abuse disorders are at least as common among persons who use medical services 18 per ¢ to 14 per ¢ o[ male users) as among those who do not 19 per ¢ to 11 per ¢ of male nonusers). The high rates of affective disorders among women and of substance abuse among male medical service risers underscore the need to increase the ability of general medical practitioners to recognize and manage or refer these conditions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PATHOLOGICAL psychology
KW  - MENTAL illness
KW  - MENTAL depression
KW  - AFFECTIVE disorders
KW  - MENTAL disabilities
KW  - HEALTH care reform
KW  - HOME care services
KW  - ANXIETY sensitivity
KW  - NATIONAL Institute of Mental Health (U.S.)
N1  - Accession Number: 4949038; Kessler, Larry G. 1,2,3,4 Burns, Barbara J. 5 Shapiro, Sam 1,2,3,4 Tischler, Gary L. George, Linda K. Hough, Richard L. Bodison, Dorothea 1,2,3,4 Miller, Richard H.; Affiliation:  1: Shapiro, Johns Hopkins University  2: Tischler, Yale University  3: George, Duke University  4: Miller, Washington University  5: Deputy Director, Division of Biometry and Applied Sciences, National Institute of Mental Health, 5600 Fishers Lane, Room 18C26, Rockville, MD 20587; Source Info: Jan1987, Vol. 77 Issue 1, p18; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL illness; Subject Term: MENTAL depression; Subject Term: AFFECTIVE disorders; Subject Term: MENTAL disabilities; Subject Term: HEALTH care reform; Subject Term: HOME care services; Subject Term: ANXIETY sensitivity; Company/Entity: NATIONAL Institute of Mental Health (U.S.); NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nagel, James E.
T1  - MOLECULAR IMMUNOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1987/01//
VL  - 37
IS  - 1
M3  - Book Review
SP  - 75
EP  - 76
SN  - 00063568
AB  - Reviews the book 'Molecular Immunology,' edited by M. Zouhair Atassi, Carel J. van Oss and Darryl R. Absolom.
KW  - Immunology
KW  - Nonfiction
KW  - Molecular Immunology (Book)
N1  - Accession Number: 10095913; Nagel, James E. 1; Affiliations: 1: National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224; Issue Info: Jan1987, Vol. 37 Issue 1, p75; Thesaurus Term: Immunology; Subject Term: Nonfiction; Reviews & Products: Molecular Immunology (Book); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 388
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hennings, Henry
AU  - Michael, Delores
AU  - Lichti, Ulrike
AU  - Yuspa, Stuart H.
T1  - Response of Carcinogen-Altered Mouse Epidermal Cells to Phorbol Ester Tumor Promoters and Calcium.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/01//
VL  - 88
IS  - 1
M3  - Article
SP  - 60
EP  - 65
SN  - 0022202X
AB  - Primary cultures of mouse epidermal cells are induced to terminally differentiate when extracellular calcium levels are increased to more than 0.1 mM After carcinogen treatment, cellular foci can be selected that resist this calcium signal to terminally differentiate Calcium causes these foci to stratify, however, in contrast to normal epidermis, DNA- synthesizing cells in these foci are found in the suprabasal cell layers as well as in basal cells Cell lines derived from these foci may be considered to be putative initiated cells Three of these cell lines, designated 308, D, and F, have been characterized for their response to calcium and phorbol ester tumor promoters. The formation of cornified cells and the activity of epidermal transglutaminase were utilized as markers of epidermal differentiation. Neither calcium nor the tumor promoter 12-O-tetradecanoylphorbol-13- acetate (TPA) increased transglutaminase activity or cornification of any of the 3 lines Proliferation was estimated by the [³H]thymidine labeling index, by incorporation of [³H]thymidine into DNA, and by a clonal growth assay. Unlike primary normal cultures, rising the calcium level of the medium did not markedly reduce the rate of proliferation of any of the 3 cell lines. in 2 of the lines, line 308 and line D, proliferation increased in response to TPA exposure. in line F, [³H]thymidine incorporation in confluent cultures was inhibited by TRA, while in cells plated at clonal densities, TPA was cytotoxic at doses of 5 ng/ml or higher. It these calcium-resistant epidermal cell lines correspond to initiated cells, their lack of sensitivity to the induction of terminal differentiation by TPA could account for their growth relative to normal cells. Those lines that also respond to stimulation of proliferation by TPA to a greater extent than normal cells would have a further growth advantage. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARCINOGENESIS
KW  - EPIDERMIS
KW  - CELLS
KW  - EPITHELIUM
KW  - PHORBOL esters
KW  - COCARCINOGENS
KW  - CALCIUM
N1  - Accession Number: 12465014; Hennings, Henry 1 Michael, Delores 1 Lichti, Ulrike 1 Yuspa, Stuart H. 1; Affiliation:  1: Vitro Pathogenesis Section, Laboratory of Cellular Carcínogenesis and Tumor Promotion, Nation Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jan1987, Vol. 88 Issue 1, p60; Subject Term: CARCINOGENESIS; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: EPITHELIUM; Subject Term: PHORBOL esters; Subject Term: COCARCINOGENS; Subject Term: CALCIUM; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12465014
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Masys, Daniel R.
AU  - Hubbard, Susan M.
T1  - Technical Information Programs of the National Cancer Institute.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
Y1  - 1987/01//
VL  - 38
IS  - 1
M3  - Article
SP  - 60
EP  - 64
SN  - 00028231
AB  - Since its founding in 1937, the National Cancer institute (NCI) has supported a substantial program of information dissemination. Two peer-reviewed journals, begun in 1940 and 1959, are supplemented by a congressionally mandated international Cancer Research Data Bank (ICRDB), established in 1972. The NCI has made available online databases of published cancer literature and cancer research in progress for the past decade, using the National Library of Medicine (NLM) MEDLARS system. Recently, a clinical-practice-oriented cancer-information system called Physician Data Query (PDQ) has been developed for access at the NLM, as well as through commercial database vendors. The impact of the NCI information programs is currently under prospective evaluation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIBRARIES
KW  - ONLINE databases
KW  - ONLINE data processing
KW  - COMMUNICATION of technical information
KW  - CANCER research
KW  - PERIODICALS
N1  - Accession Number: 16771829; Masys, Daniel R. 1,2; Hubbard, Susan M. 1; Affiliations: 1: International Cancer Research Data Bank Branch, National Cancer Institute, Bethesda, MD 20892; 2: International Cancer Information Center, National Cancer Institute, Bethesda, MD 20892; Issue Info: Jan1987, Vol. 38 Issue 1, p60; Thesaurus Term: LIBRARIES; Thesaurus Term: ONLINE databases; Thesaurus Term: ONLINE data processing; Subject Term: COMMUNICATION of technical information; Subject Term: CANCER research; Subject Term: PERIODICALS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 519121 Libraries; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 519120 Libraries and Archives; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - GEN
AU  - Crump, T
T1  - Scientific/technical translations in a research library
JO  - Reference Librarian
JF  - Reference Librarian
Y1  - 1987///Spr
IS  - 17
M3  - Article
SP  - 113
EP  - 122
SN  - 02763877
AB  - This paper reviews the past use of the translation diary to aid the translator in library work. The author focuses on how libraries have helped to solve the types of problems recorded in the diary. A short bibliography is given on journals that are available in translation.
KW  - REFERENCE services (Libraries)
KW  - RESEARCH libraries
KW  - Scientific information
KW  - Technical information
N1  - Accession Number: ISTA2202445; Crump, T 1; Affiliations: 1 : National Institutes of Health Library, Bethesda, MD;  Source Info: Spr 1987 Issue 17, p113; Note: Update Code: 2200; Subject Term: REFERENCE services (Libraries); Subject Term: RESEARCH libraries; Author-Supplied Keyword: Scientific information; Author-Supplied Keyword: Technical information; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2006-06444-063
AN  - 2006-06444-063
AU  - Tabakoff, Boris
T1  - How Alcohol Intoxicates.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/01//
VL  - 32
IS  - 1
SP  - 77
EP  - 77
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06444-063. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tabakoff, Boris; Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alcohol Intoxication; Biology; Neurochemistry. Minor Descriptor: Chemicals; Ethanol; Membranes; Proteins; Toxic Disorders. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Hunt, Walter A. Alcohol and Biological Membranes=New York: Guilford Press, 1985. 214 pp. $25.00; 1985. Page Count: 1. Issue Publication Date: Jan, 1987. 
AB  - Reviews the book, Alcohol and Biological Membranes by Walter A. Hunt (1985). In Alcohol and Biological Membranes, Hunt addresses the enigma of how a molecule with so little inherent chemical information can produce the characteristic and extensive signs of alcohol intoxication. The volume is organized to demonstrate the 'ripple effect' of alcohol's actions, wherein minute perturbations of membrane order produced by ethanol are amplified through subsequent perturbations of the function of membrane proteins. There are several features that distinguish this book from prior attempts to catalog and interpret data relating to the molecular site of ethanol's actions. Another laudable feature of this volume is the clear effort of the author to avoid a dogmatic approach to interpretation of the multitude of experimental results. A reader who hopes this book will provide a clear understanding of alcohol's mechanisms of action will surely be disappointed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - biochemistry
KW  - alcohol intoxication
KW  - membrane proteins
KW  - ethanol's actions
KW  - chemicals
KW  - 1987
KW  - Alcohol Intoxication
KW  - Biology
KW  - Neurochemistry
KW  - Chemicals
KW  - Ethanol
KW  - Membranes
KW  - Proteins
KW  - Toxic Disorders
KW  - 1987
U2  - Hunt, Walter A. (1985); Alcohol and Biological Membranes; New York: Guilford Press, 1985. 214 pp. $25.00
DO  - 10.1037/026701
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09762-008
AN  - 2005-09762-008
AU  - Marcus, Joseph
AU  - Hans, Sydney L.
AU  - Nagler, Shmuel
AU  - Auerbach, Judith G.
AU  - Mirsky, Allan F.
AU  - Aubrey, Annie
T1  - Review of the NIMH Israeli Kibbutz-City Study and the Jerusalem Infant Development Study.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1987///
VL  - 13
IS  - 3
SP  - 425
EP  - 438
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Marcus, Joseph, 910 Chelham Way, Santa Barbara, CA, US, 93108
N1  - Accession Number: 2005-09762-008. PMID: 3629198 Partial author list: First Author & Affiliation: Marcus, Joseph; Unit for Research in Child Psychiatry and Development, University of Chicago, Chicago, IL, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20150914. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Infant Development; Offspring; Parents; Schizophrenia. Minor Descriptor: Perceptual Motor Processes; Social Skills. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: Israel. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Taylor Closure Test; Sarason General Anxiety Scale for Children; Schedule for Affective Disorders and Schizophrenia -Lifetime Version; Bender Gestalt Test; Sentence Completion Series; Social Adjustment Scale DOI: 10.1037/t32027-000; Thematic Apperception Test (TAT); Wechsler Adult Intelligence Scale  (WAIS); Wechsler Intelligence Scale for Children. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 1987. 
AB  - The National Institute of Mental Health (NIMH) Israeli Kibbutz-City Study has followed the development of offspring of schizophrenic parents from middle childhood through early adulthood. During childhood, a subgroup of offspring of schizophrenic patients showed clear neurobehavioral deficits often accompanied by poor social competence. Early followup data suggest that this subgroup of high-risk children is at greatest risk for adult schizophrenia spectrum illness. The Jerusalem Infant Development Study has followed a similar population of children at risk for schizophrenia from before birth through middle childhood. A subgroup of high-risk children showed sensorimotor dysfunctioning in the first year of life, which was followed by perceptual, motor, and attentional dysfunctioning in childhood--identical to that found in the NIMH cohort. Results from both studies support the hypothesis that schizophrenic illness involves constitutional factors whose expression can be observed as early as infancy. Results also illustrate the importance of using data-analytic approaches that (1) look for subgroups within high-risk groups rather than only group differences between high- and low-risk groups, and (2) examine profiles of behavior rather than only single variables. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - infant development
KW  - schizophrenic parents
KW  - offsprings
KW  - social competence
KW  - neurobehavioral deficits
KW  - at risk populations
KW  - sensorimotor dysfunctioning
KW  - 1987
KW  - At Risk Populations
KW  - Infant Development
KW  - Offspring
KW  - Parents
KW  - Schizophrenia
KW  - Perceptual Motor Processes
KW  - Social Skills
KW  - 1987
DO  - 10.1093/schbul/13.3.425
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - BRANN, MARK R.
AU  - COHEN, LESLIE V.
T1  - Diurnal Expression of Transducin mRNA and Translocation of Transducin in Rods of Rat Retina.
JO  - Science
JF  - Science
Y1  - 1987/01/30/
VL  - 235
IS  - 4788
M3  - Article
SP  - 585
EP  - 587
SN  - 00368075
AB  - The messenger RNA (mRNA) that encodes a subunit of the guanosine triphosphatebinding protein transducin (Tα) and Ta immunoreactivity were lli and measured in the rat retina during the light-dark cyde with in situ hybridization and immunohistochemistry. Both Tα mRNA and Tα immunoreactivity were observed only in photoreceptors. Within the photoreceptor Tα mRNA was present primarily in the inner segments and to a lesser extent in the outer nudear layer at all times during the day and night. However, the distribution of Tα immunoreactivity varied profoundly with the light-dark cycle; during the day, Tα immunoreactivity was highest in the inner segments, and at night the outer segments were more immunoreactive. The amounts of Tα mRNA and Tα immunoreactivity also depended on the light-dark cyde. Levels of Tα mRNA were high immediately before and after lights on; levels were low for the rest of the light-dark cyde. During the day, Ta immunoreactivity increased in the inner segments following the increase in Tα mRNA. After the lights were turned off, Ta immunoreactivity decreased in the inner segments and increased in the outer segments. Thus, it appears that Tα is synthesized in the inner segments after a morning increase in Ta mRNA. Newly synthcsized Tα remains in the inner segents until it is transported to the outer segments at night, where it may be involved in the increase in the sensitivity of photoreceptor rods at night. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461230; BRANN, MARK R. 1,2 COHEN, LESLIE V. 1; Affiliation:  1: Laboratory of Cell Biology, National Institute of Mental Health, Room 3A-17, Building 36, Bethesda, MD 20892  2: Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 9C-101, Building 10, Bethesda, MD 20892; Source Info: 1/30/1987, Vol. 235 Issue 4788, p585; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Joffres, Michel R.
AU  - Reed, Dwayne M.
AU  - Yano, Katsuhiko
T1  - Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/02//
VL  - 45
IS  - 2
M3  - Article
SP  - 469
EP  - 475
SN  - 00029165
AB  - Associations between blood pressure and intakes of 61 dietary variables assessed by 24-h recall method were investigated in 615 men of Japanese ancestry living in Hawaii who had no history of cardiovascular disease or treated hypertension. Magnesium, calcium, phosphorus, potassium, fiber, vegetable protein, starch, vitamin C, and vitamin D intakes were significant variables that showed inverse associations with blood pressure in univariate and a multivariate analyses. Magnesium had the strongest association with blood pressure, which supports recent interest in its relation to blood pressure. Nevertheless, it was not possible to separate the effect of magnesium from that of other variables because of the problem of high intercorrelation among many nutrients. While recommendations based upon cross-sectional studies must be viewed cautiously, these results suggest that foods such as vegetables, fruits, whole grains, and low-fat dairy items are major sources of nutrients that may be protective against hypertension. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Magnesium in the body
KW  - Blood pressure
KW  - Cardiovascular diseases
KW  - Hypertension
KW  - Honolulu (Hawaii)
KW  - magnesium
KW  - nutrition
N1  - Accession Number: 91095377; Joffres, Michel R. 1; Reed, Dwayne M. 2; Yano, Katsuhiko 1; Affiliations: 1: Honolulu Heat Program, National Heart, Lung and Blood Institute, Honolulu, HI; 2: Kuakini Medical Center and the Honolulu Heart Program National Heart, Lung and Blood Institute, Honolulu, HI; Issue Info: Feb1987, Vol. 45 Issue 2, p469; Subject Term: Magnesium in the body; Subject Term: Blood pressure; Subject Term: Cardiovascular diseases; Subject Term: Hypertension; Subject: Honolulu (Hawaii); Author-Supplied Keyword: magnesium; Author-Supplied Keyword: nutrition; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - SorIie, Paul D.
AU  - Gold, Ellen B.
T1  - The Effect of Physician Terminology Preference on Coronary Heart Disease Mortality: An Artifact Uncovered by the 9th Revision ICD.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/02//
VL  - 77
IS  - 2
M3  - Article
SP  - 148
EP  - 152
PB  - American Public Health Association
SN  - 00900036
AB  - We dual coded 2,268 deaths due to heart disease occurring in Maryland, using the 8th and 9th revisions of the International Classification of Diseases (ICDA-8, Adapted for Use in the United States, and ICD-9). Certifier preference was for generalized cardiovascular terms rather than terms specific to the heart, resulting in an artifactual change in chronic ischemic heart disease death (IHD) rates in Maryland between 1978 and 1979 because the 8th and 9th ICD revisions classified these terms differently. Medical examiners were more likely to use these generalized cardiovascular terms as were physicians who went to certain medical schools in the state. The physician's terminology preference was associated with the sex and race of the decedent and was related to aspects of the patient's medical care. The ICD should be modified in the 10th revision to allow for the separate classification of generalized cardiovascular terminology within the ischemic heart disease category. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL care -- Research
KW  - MEDICAL terminology
KW  - MEDICAL screening
KW  - CORONARY heart disease
KW  - CARDIOVASCULAR diseases
KW  - HEART diseases
KW  - PERIODIC health examinations
KW  - PHYSICIAN & patient
KW  - MORTALITY
KW  - MARYLAND
N1  - Accession Number: 4949698; SorIie, Paul D. 1 Gold, Ellen B. 2; Affiliation:  1: National Institutes of Health, National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Federal Building, Room 3A-10, Bethesda, MD 20892  2: Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore; Source Info: Feb1987, Vol. 77 Issue 2, p148; Subject Term: MEDICAL care -- Research; Subject Term: MEDICAL terminology; Subject Term: MEDICAL screening; Subject Term: CORONARY heart disease; Subject Term: CARDIOVASCULAR diseases; Subject Term: HEART diseases; Subject Term: PERIODIC health examinations; Subject Term: PHYSICIAN & patient; Subject Term: MORTALITY; Subject Term: MARYLAND; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Riley, Matilda White
T1  - ON THE SIGNIFICANCE OF AGE IN SOCIOLOGY.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1987/02//
VL  - 52
IS  - 1
M3  - Article
SP  - 1
EP  - 14
SN  - 00031224
AB  - A sociology of age provides an analytical framework for understanding the interplay between human lives and changing social structures. Its mission is to examine the interdependence between (1) aging over the life course as a social process and (2) societies and groups as stratified by age, with the succession of cohorts as the link connecting the two. This special field of age draws on sociology as a whole and contributes to it through reformulation of traditional emphases on process and change, on the multiple interdependent levels of the system, and on the multidimensionality of sociological concerns as they touch on related aspects of other disciplines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AGING
KW  - SOCIAL psychology
KW  - SOCIAL structure
KW  - HUMAN life cycle
KW  - SOCIAL stratification
KW  - SOCIOLOGICAL research
N1  - Accession Number: 14773623; Riley, Matilda White 1; Affiliation:  1: National institutes of Health.; Source Info: Feb87, Vol. 52 Issue 1, p1; Subject Term: AGING; Subject Term: SOCIAL psychology; Subject Term: SOCIAL structure; Subject Term: HUMAN life cycle; Subject Term: SOCIAL stratification; Subject Term: SOCIOLOGICAL research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wolfe, Mary D.
AU  - Carlos, James P.
T1  - Periodontal disease in adolescents: epidemiologic findings in Navajo Indians.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1987/02//
VL  - 15
IS  - 1
M3  - Article
SP  - 33
EP  - 40
SN  - 03015661
AB  - A cross-sectional epidemiologic survey was conducted of 618 Navajo Indians, aged 14-19,. resident in a boarding school in New Mexico. Periodontal status was assessed by clinical measurements of attachment level and gingival bleeding, and evidence of alveolar bone loss from standardized bitewing radiographs. Attachment level and gingival bleeding were measured at 24 posterior interproximal sites (six sites in each quadrant): the mesio-buccal aspect of the second molar; the disto-buccal and mesio-buccal aspects of the first molar and second premolar; and the disto-buccal aspect of the first premolar. Alveolar bone level was measured from radiographs at the corresponding approximal surfaces of the same teeth. Attachment loss was considered present when the distance from the CEJ to the base of the pocket was > 1 mm; bone loss was considered present when the radiographic distance from the CEJ to the alveolar crest was > 2 mm, and gingival bleeding was considered present if bleeding occurred immediately after gentle probing. Attachment loss was evident at one or more sites in 88.7% of the population, 45.9% of the subjects had attachment loss at eight or more sites, and 101 subjects (16.3%) had one or more sites with at least 4.0 mm of attachment loss. Bone loss was present at one or more sites in 89.2% of the population, 28.6% had eight or more affected sites, and 4.7% (29 subjects) had one or more sites with at least 2.0 mm of bone loss. Gingival bleeding was evident at one or more sites in 70.6% of the population, and 19.7% had eight or more affected sites. None of the conditions were strongly associated with sex, but the prevalence of bone loss increased with age. The prevalence and severity of incipient periodontitis seemed much higher in these subjects than previously reported in other adolescent groups when similar diagnostic criteria and methods of measurement were used. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERIODONTAL disease
KW  - PERIODONTICS
KW  - GUM disease
KW  - EPIDEMIOLOGY
KW  - GINGIVITIS
KW  - MEXICO
KW  - adolescence
KW  - epidemiology
KW  - Indians
KW  - North American: Navajo
KW  - oral
KW  - periodontal diseases
N1  - Accession Number: 12038976; Wolfe, Mary D. 1 Carlos, James P. 1; Affiliation:  1: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Feb1987, Vol. 15 Issue 1, p33; Subject Term: PERIODONTAL disease; Subject Term: PERIODONTICS; Subject Term: GUM disease; Subject Term: EPIDEMIOLOGY; Subject Term: GINGIVITIS; Subject Term: MEXICO; Author-Supplied Keyword: adolescence; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: Indians; Author-Supplied Keyword: North American: Navajo; Author-Supplied Keyword: oral; Author-Supplied Keyword: periodontal diseases; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1600-0528.ep12038976
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hintner, Helmut
AU  - Romani, Nikolaus
AU  - Stanzl, Ursula
AU  - Grubauer, Gerhard
AU  - Fritsch, Peter
AU  - Lawley, Thomas J.
T1  - Phagocytosis of Keratin Filament Aggregates Following Opsonization With IgG-Anti-Keratin Filament Autoantibodies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/02//
VL  - 88
IS  - 2
M3  - Article
SP  - 176
EP  - 182
SN  - 0022202X
AB  - IgG-anti-keratin intermediate filament autoantibodies occur in low titers in all normal human sera. These same antibodies are present in high titers in the sera of patients who have diseases in which cells containing keratin intermediate filaments (KIF) have been damaged, such as systemic lupus erythematosus, graft-versus-host disease, and cutaneous tumors. Since some human autoantibodies are thought to function in part as opsonins promoting the removal of insoluble cellular proteins after tissue injury, we investigated the influence of IgG-anti-KIF autoantibodies on the phagocytosis of insoluble KIF aggregates by human monocytes and polymorphonuclear neutrophils (PMN). Keratin intermediate filaments assembled in vitro were reconstituted into dense spherical KIF aggregates 0.3-2.5 μm in diameter by dialysis against phosphate-buffered saline. Immunoelectron microscopy revealed that, as expected, human IgG-anti-KIF autoantibodies bound to the KIF aggregates. Human monocytes or PMN were incubated either with nonopsonized KIF aggregates or with KIF aggregates that had been reacted with IgG-anti-KIF autoantibodies. The uptake of KIF aggregates was visualized by indirect immunofluorescence, immunoperoxidase staining, and immunoelectron microscopy. Monocytes rapidly and efficently bound and phagocy tosed KIF aggregates that had ben coated with IgG-anti-KIF autoantibodies. Nonopsonized KIF Agregates, in contrast, were taken up much less efficiently. Differences were most marked at 4°C for 60 min with phagocytosis of opsonized KIF aggregates by 23 ± 8% of monocytes in contrast to phagocytosis by only 0.2 ± 3% monocyted in contrast to phagocytosis  when nonopsonized KIF aggregates were used. Similar results occurred at 37°C for 5 min with phagocytosis by 38 ± 28% vs 1.8 ± 0.4% of monocytes of opsonized and nonopsonized KIF aggregates, respectively. A high percentage of PMN also phagocytosed opsonized KIF aggregates, whereas nonopsonized KIF aggregates wereingested less avidly. These data indicate that the opsonization of extracellular KIF aggregates by IgG-anti-KIF autoantiobodies plays an important role in promoting the phagocytosis of KIF aggregates. The subsequent phagocytosis represents a rapid and very effectivemechanism for the removal of insoluble KIF following keratinocyte cell death. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHAGOCYTOSIS
KW  - KERATIN
KW  - IMMUNOGLOBULIN G
KW  - AUTOANTIBODIES
KW  - IMMUNE response
KW  - SERUM
N1  - Accession Number: 12525322; Hintner, Helmut 1 Romani, Nikolaus 1 Stanzl, Ursula 1 Grubauer, Gerhard 1 Fritsch, Peter 1 Lawley, Thomas J. 2; Affiliation:  1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb87, Vol. 88 Issue 2, p176; Subject Term: PHAGOCYTOSIS; Subject Term: KERATIN; Subject Term: IMMUNOGLOBULIN G; Subject Term: AUTOANTIBODIES; Subject Term: IMMUNE response; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12525322
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tschachler, Erwin
AU  - Groh, Veronika
AU  - Popovic, Mikulas
AU  - Mann, Dean L.
AU  - Konrad, Klaus
AU  - Safai, Bijan
AU  - Eron, Lawrence
AU  - DiMarzo Veronese, Fulvia
AU  - Wolff, Klaus
AU  - Stingl, Georg
T1  - Epidermal Langerhans Cells-A Target for HTLV-III/LAV Infection.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/02//
VL  - 88
IS  - 2
M3  - Article
SP  - 233
EP  - 237
SN  - 0022202X
AB  - Langerhans cells (LC) are bone marrow-derived, la+, CD1+, CD4+, ATPase+ dendritic antigen-presenting cells within the human epidermis. Since the CD4 molecule has been implicated as a receptor structure for HTLV-III/LAV (human T-cell leukemia virus/lymphadenopathy-associated virus), we asked whether LC from HTLV-III/LAV-seropositive individuals display signs of HTLV-III/LAV infection. In skin biopsies from 7/40 HTLV-III/LAV-infected persons (1 asymptomatic carrier, 2 patients with acquired immunodeficiency syndrome (AIDS)-related complex and 4 patients with AIDS), LC were the only epidermal cells to react with a monoclonal antibody specific for the HTLV-III core protein p17. A varying percentage of p17+ LC were morphologically altered with blunt dendrites and poorly demarcated cellular contours. In one of these biopsies, the presence of LC-associated viral particles characteristic of HTLV-III/LAV as well as cytopathic changes in approximately one-third of the LC population were demonstrated by electron microscopy. These results strongly suggest that LC may harbor HTLV-III/LAV. The infection of LC with this retrovirus may have deleterious consequences for the immunologic functions of this cell system and may thus contribute to both the acquisition of immunodeficiency and the infectious and neoplastic complications of AIDS. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS patients
KW  - LANGERHANS cells
KW  - EPIDERMIS
KW  - HIV infections
KW  - IMMUNE system
KW  - CD4 antigen
N1  - Accession Number: 12525402; Tschachler, Erwin 1 Groh, Veronika 1 Popovic, Mikulas 2 Mann, Dean L. 3 Konrad, Klaus 1 Safai, Bijan 4 Eron, Lawrence 5 DiMarzo Veronese, Fulvia 6 Wolff, Klaus 1 Stingl, Georg 1,7; Affiliation:  1: Department of Dermatology I, University of Vienna Medical School, Vienna, Austria.  2: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  3: Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  4: Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.  5: Infectious Disease Section, Fairfax Hospital, Falls Church, Virginia.  6: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland.  7: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb87, Vol. 88 Issue 2, p233; Subject Term: AIDS patients; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; Subject Term: HIV infections; Subject Term: IMMUNE system; Subject Term: CD4 antigen; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12525402
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06445-068
AN  - 2006-06445-068
AU  - Shah, Saleem A.
T1  - Mental Health Aspects of Violence.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/02//
VL  - 32
IS  - 2
SP  - 185
EP  - 186
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06445-068. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Criminal Behavior; Domestic Violence; Mental Health; Suicide; Violence. Minor Descriptor: History. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Reviewed Item: Aronowitz, Eugene (Ed); Sussman, Robert (Ed). Mental Health and Violence=Canton, MA: Prodist, 1985. 129 pp. $6.95 paperback; 1985. Page Count: 2. Issue Publication Date: Feb, 1987. 
AB  - Reviews the book, Mental Health and Violence edited by Eugene Aronowitz and Robert Sussman (1985). This book consists of presentations made on that occasion, as well as some additional material. It is not entirely clear what audiences the editors had in mind when they decided to publish this compilation. The presentations in this volume cover such topics as sources of violence in American history, domestic or family violence, child sexual abuse and incest, criminal violence, suicidal behavior in children, adolescents and adults, and drug abuse considered as inwardly directed violence. This volume also displays much variation even in the citation and reference styles used by the numerous contributors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - violence
KW  - criminal violence
KW  - American history
KW  - suicidal behavior
KW  - 1987
KW  - Criminal Behavior
KW  - Domestic Violence
KW  - Mental Health
KW  - Suicide
KW  - Violence
KW  - History
KW  - 1987
U2  - Aronowitz, Eugene (Ed); Sussman, Robert (Ed). (1985); Mental Health and Violence; Canton, MA: Prodist, 1985. 129 pp. $6.95 paperback
DO  - 10.1037/026814
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Blot, William J.
AU  - Fraumeni, Joseph F.
T1  - Trends in Esophageal Cancer Mortality among US Blacks and Whites.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/03//
VL  - 77
IS  - 3
M3  - Article
SP  - 296
EP  - 298
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: National age-adjusted rates of mortality from esophageal cancer have increased among Blacks in the United States. while remaining nearly unchanged among Whites. By 1980, esophageal cancer had become one of the leading causes of cancer death among Blacks, with the excess among males under age 55 exceeding six-fold. Inferences about the causes of esophageal cancer cannot be made from this descriptive survey, but the rising trend raises etiologic hypotheses about environmental exposures (e.g., alcohol tobacco nutrition) that may differentially affect Blacks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESOPHAGEAL cancer
KW  - CANCER -- Mortality
KW  - CANCER patients
KW  - MORTALITY
KW  - AFRICAN Americans -- Diseases
KW  - AFRICAN Americans -- Mortality
KW  - HEALTH behavior
KW  - HEALTH surveys
KW  - UNITED States
N1  - Accession Number: 4949757; Blot, William J. 1 Fraumeni, Joseph F. 2; Affiliation:  1: Chief, Biostatistics Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892  2: Associate Director of the Program, Biostatistics Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892; Source Info: Mar1987, Vol. 77 Issue 3, p296; Subject Term: ESOPHAGEAL cancer; Subject Term: CANCER -- Mortality; Subject Term: CANCER patients; Subject Term: MORTALITY; Subject Term: AFRICAN Americans -- Diseases; Subject Term: AFRICAN Americans -- Mortality; Subject Term: HEALTH behavior; Subject Term: HEALTH surveys; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaplan, George A.
AU  - Seeman, Teresa E.
AU  - Cohen, Richard D.
AU  - Knudsen, Lisa P.
AU  - Guralnik, Jack
T1  - Mortality among the Elderly in the Alameda Country Study: Behavioral and Demographic Risk Factors.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/03//
VL  - 77
IS  - 3
M3  - Article
SP  - 307
EP  - 312
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We studied the association between behavioral and demographic risk factors and 17-year mortality in members of the Alameda County (California) Study who were 60-94 years of age at baseline. In this age group, increased risk of death is associated with being male. smoking, having little leisure-time physical activity, deviating from moderate weight relative to height, and not regularly eating breakfast. These increased risks were independent of age, race, socioeconomic position (SEP), other behavioral risk factors, and baseline physical health status. Further examination of the group aged 70 or more revealed the same patterns of heightened risk. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH risk assessment
KW  - BEHAVIORAL assessment
KW  - HEALTH status indicators
KW  - MORTALITY
KW  - HUMAN behavior
KW  - DEATH -- Psychological aspects
KW  - BEREAVEMENT -- Psychological aspects
KW  - PHYSICAL fitness for older people
KW  - ALAMEDA County (Calif.)
KW  - CALIFORNIA
N1  - Accession Number: 4949767; Kaplan, George A. 1 Seeman, Teresa E. 2 Cohen, Richard D. 3 Knudsen, Lisa P. 3 Guralnik, Jack 4; Affiliation:  1: Human Population Laboratory California Department of Health Services, 2151 Berkeley Way, Annex 2, Room 211, Berkeley, CA 94704-9980  2: Department of Epidemiology and Public Health, Yale University  3: HPL  4: National Institute on Aging/NIH, Bethesda, MD; Source Info: Mar1987, Vol. 77 Issue 3, p307; Subject Term: HEALTH risk assessment; Subject Term: BEHAVIORAL assessment; Subject Term: HEALTH status indicators; Subject Term: MORTALITY; Subject Term: HUMAN behavior; Subject Term: DEATH -- Psychological aspects; Subject Term: BEREAVEMENT -- Psychological aspects; Subject Term: PHYSICAL fitness for older people; Subject Term: ALAMEDA County (Calif.); Subject Term: CALIFORNIA; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Magrath, Ian T.
T1  - IMMUNOGENETICS.
JO  - BioScience
JF  - BioScience
Y1  - 1987/03//
VL  - 37
IS  - 3
M3  - Book Review
SP  - 228
EP  - 229
SN  - 00063568
AB  - Reviews the book "Immunogenics: Its Application to Clinical Medicine," edited by Takehiko Sasazuki and Tomio Tadi.
KW  - Immunology
KW  - Nonfiction
KW  - Immunogenics (Book)
N1  - Accession Number: 10102222; Magrath, Ian T. 1; Affiliations: 1: Senior Investigator, Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892; Issue Info: Mar1987, Vol. 37 Issue 3, p228; Thesaurus Term: Immunology; Subject Term: Nonfiction; Reviews & Products: Immunogenics (Book); Number of Pages: 2p; Illustrations: 1 Cartoon or Caricature; Document Type: Book Review; Full Text Word Count: 886
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Suwalsky, Joan T.D.
AU  - Klein, Robert P.
AU  - Zaslow, Martha J.
AU  - Rabinovich, Beth A.
AU  - Gist, Nancy F.
T1  - Dimensions of Naturally Occurring Mother-Infant Separations During the First Year of Life.
JO  - Infant Mental Health Journal
JF  - Infant Mental Health Journal
Y1  - 1987///Spring87
VL  - 8
IS  - 1
M3  - Article
SP  - 3
EP  - 18
PB  - John Wiley & Sons, Inc.
SN  - 01639641
AB  - The goals of this paper are (1) to introduce a methodology developed to study mother-infant separations that occur in the context of normal family life, including but going beyond separations associated with maternal employment; (2) to present illustrative data that describe the range of separations experienced by one sample of infants; and (3) to demonstrate how a focus on specific underlying dimensions results in a more precise characterization of the separation experience. It is necessary to identify the specific dimensions on which mother-infant separations vary in order to clarify which aspects of separation are relevant to child outcome. Detailed histories of mother-infant separations and concomitant substitute care during the first year of life ware obtained by interview from 144 middle-class mothers of first-born infants. Far from being an unusual event, separation from mother was a normal experience during infancy for this sample. Six types of separation were identified, the majority of which have not been studied previously. Analyses indicated that naturally occurring mother-infant separations can be differentiated statistically and compared in terms of amount of separation, stability of care, characteristics of caregivers, and characteristics of the substitute care setting. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Infant Mental Health Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOTHER & infant
KW  - SEPARATION anxiety in infants
KW  - FAMILIES
KW  - FAMILY relations
KW  - EMPLOYMENT (Economic theory)
KW  - WORKING mothers
KW  - CHILD development
KW  - WORK & family
KW  - INFANTS -- Care
KW  - SEPARATION (Psychology)
N1  - Accession Number: 12035318; Suwalsky, Joan T.D. 1 Klein, Robert P. 1 Zaslow, Martha J. 1 Rabinovich, Beth A. 1 Gist, Nancy F. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development; Source Info: Spring87, Vol. 8 Issue 1, p3; Subject Term: MOTHER & infant; Subject Term: SEPARATION anxiety in infants; Subject Term: FAMILIES; Subject Term: FAMILY relations; Subject Term: EMPLOYMENT (Economic theory); Subject Term: WORKING mothers; Subject Term: CHILD development; Subject Term: WORK & family; Subject Term: INFANTS -- Care; Subject Term: SEPARATION (Psychology); Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - George, David T.
AU  - Weiss, Sandra R.
AU  - Gwirtsman, Harry E.
AU  - Blazer, Dan
T1  - Hospital Treatment of Anorexia Nervosa: A 25 Year Retrospective Study from 1958 to 1982.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1987/03//
VL  - 6
IS  - 2
M3  - Article
SP  - 321
EP  - 330
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - In order to characterize changes in the presenting symptomatology and treatment of anorexia nervosa (AN), the hospital charts of 76 anorexia nervosa patients were reviewed form three time periods: (I) 1958–1962, (II) 1969–1972, and (III) 1978–1982. in period I, 92% of the patient were admitted to a medicines service, whereas in period III, 92% were admitted to psychiatry. Age of onset, percent mean weight for height upon admission, and reported frequencies of laxative use and vomiting showed no statistical differences among the periods. Length of hospital stay and weight gained during hospitalization increased significantly during period III, with similar stays occurring for both vomiters and restrictors. Between periods I and III the number of medical diagnostic studies decreased while the frequency of behavioral therapies and use of antidepressant medication increased. During the past 25 years, theories of etiology and approaches to treatment of anorexia nervosa have become increasingly psychiatric. We postulate that the apparent increasing incidence of AN may partially be attributable to an underdiagnosis of AN by medical services in the past. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANOREXIA nervosa
KW  - APPETITE loss
KW  - EATING disorders
KW  - PATIENTS
KW  - APPETITE disorders
KW  - HOSPITAL care
KW  - PSYCHIATRY
KW  - SYMPTOMS
KW  - PATHOLOGICAL psychology
N1  - Accession Number: 12056246; George, David T. 1 Weiss, Sandra R. 1 Gwirtsman, Harry E. 2 Blazer, Dan 3; Affiliation:  1: National Institute of Mental Health, Section on Biomedical Psychiatry, Laboratory of Clinical Science, Bethesda, Maryland  2: UCLA Neuropsychiatric Institute, Los Angeles, California  3: Duke University, Durham, North Carolina; Source Info: Mar1987, Vol. 6 Issue 2, p321; Subject Term: ANOREXIA nervosa; Subject Term: APPETITE loss; Subject Term: EATING disorders; Subject Term: PATIENTS; Subject Term: APPETITE disorders; Subject Term: HOSPITAL care; Subject Term: PSYCHIATRY; Subject Term: SYMPTOMS; Subject Term: PATHOLOGICAL psychology; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Taylor, Edward H.
T1  - The Biological Basis of Schizophrenia.
JO  - Social Work
JF  - Social Work
Y1  - 1987/03//Mar/Apr87
VL  - 32
IS  - 2
M3  - Article
SP  - 115
PB  - Oxford University Press / USA
SN  - 00378046
AB  - The article presents a study which considered the biological basis of schizophrenia. As part of the study the neurological changes in persons with schizophrenia are observed. Techniques adopted in the diagnosis of the mental illness are elaborated in the article. Assessment of the role of family environments in the acquisition of the illness is further undertaken. Neuropsychiatric studies using modem brain imaging techniques are rapidly redefining schizophrenia. Physical and chemical changes found In the brain have largely discredited beliefs that environment, attachment family interactions, or stress cause schizophrenia. Combining the new biological knowledge with methods of social work practice is of immediate importance, especially when one considers the number of individuals who suffer from schizophrenia and the number of families that are affected by a member's illness. In this context Researchers at the National Institute of Mental Health (MMII) have classified schizophrenia as a group of brain disease.
KW  - SCHIZOPHRENIA
KW  - MENTAL illness
KW  - PATHOLOGICAL psychology
KW  - SCHIZOTYPAL personality disorder
KW  - BRAIN diseases
KW  - DEVELOPMENTAL disabilities
N1  - Accession Number: 5271069; Taylor, Edward H. 1; Affiliation:  1: Clinical and Research Social Worker, Neuropsychiatric Branch, National Institute of Mental Health, W A. White Building, Saint Elizabeths Hospital, Washington, DC 20032.; Source Info: Mar/Apr87, Vol. 32 Issue 2, p115; Subject Term: SCHIZOPHRENIA; Subject Term: MENTAL illness; Subject Term: PATHOLOGICAL psychology; Subject Term: SCHIZOTYPAL personality disorder; Subject Term: BRAIN diseases; Subject Term: DEVELOPMENTAL disabilities; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - SEGUIN, CARL
AU  - HAMER, DEAN H.
T1  - Regulation in Vitro of Metallothionein Gene Binding Factors.
JO  - Science
JF  - Science
Y1  - 1987/03/13/
VL  - 235
IS  - 4794
M3  - Article
SP  - 1383
EP  - 1387
SN  - 00368075
AB  - Mouse nuclear factors that bind to an upstream metal regulatory element of the mouse metallothionein-I gene have been identified by DNA footprinting and oligonucleotide band shift assays. The formation of complexes at this site can be activated 20- to 40- fold by the in vitro addition of ionic cadmium. The activation reaction is rapid, reversible by a metal chelator, and may involve multiple proteins. These results suggest that the initial step in cadmium detoxification is an interaction between the metal and nuclear DNA-binding factors leading to an increase in metallothionein gene transcription. The ability to observe meal activation in vitro makes this a powerful system to study the biochemistry of eukaryotic gene regulation. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87461279; SEGUIN, CARL 1 HAMER, DEAN H. 2; Affiliation:  1: Molecular Endocrinology Laboratory, Laval University Medical Center, Ste. Fosy, Quebec, Canada G1V4GZ  2: Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892; Source Info: 3/13/1987, Vol. 235 Issue 4794, p1383; Number of Pages: 5p; Document Type: Article
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TY  - JOUR
AU  - Aerts, Johannes M. F. G.
AU  - Donker-Koopman, Wilma E.
AU  - Van Laar, Coos
AU  - Brul, Stanley
AU  - Murray, Gary J.
AU  - Wenger, David A.
AU  - Barranger, John A.
AU  - Tager, Joseph M.
AU  - Schram, André W.
T1  - Relationship between the two immunologically distinguishable forms of glucocerebrosidase in tissue extracts.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/03/16/
VL  - 163
IS  - 3
M3  - Article
SP  - 583
EP  - 589
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Extracts of human spleen contain two immunologically distinguishable forms of  glucocerebrosidase: form I is precipitable by polyclonal or monoclonal anti-(placental glucocerebrosidase)  antibodies, whereas form II is not [Aerts, J. M. F. G., Donker-Koopman, W. E., Van der Vliet, M. F. K., Jonsson, L.  M. V., Ginns, E. I., Murray, G. J., Barranger, J. A., Tager, J. M. & Schram, A. W. (1985) Fur. J.  Biochem. 150, 565-574]. The proportion of form II glucocerebrosidase was high in extracts of spleen, liver and kidney and  low in extracts of brain, placenta and fibroblasts. Furthermore, the proportion of form II enzyme was higher in a  detergent-free aqueous extract of spleen than in a Triton X-100 extract of total spleen or splenic membranes.  When form II ghicocerebrosidase in a splenic extract was separated from form I enzyme by immunoaffinity  chromatography and stored at  4°C, a gradual conversion to form I enzyme occurred. The conversion was almost  immediate if 30% (v/v) ethylene glycol was present. In the denatured state both forms of glucocerebrosidase reacted  with anti-(placental glucocerebrosidase) antibodies. Form I glucocerebrosidase was stimulated by sodium taurocholate or  sphingolipid-activator protein 2 (SAP-2), whereas form II enzyme exhibited maximal activity in the  absence of the effectors. The pH activity profile of form II glucocerebrosidase was almost identical to  that of form I enzyme in the presence of SAP-2. In the native state, form I glucocerebrosidase had a molecular mass of  60 kDa whereas that of form II glucocerebrosidase was about 200 kDa. After gel-permeation high-performance  liquid chromatography of splenic extracts, the fractions with form II glucocerebrosidase contained material  cross-reacting with both anti-(placental glucocerebrosidase) and anti-(SAP-2) antibodies. Preincubation of form I  glucocerebrosidase with SAP-2 at pH 4.5 led to masking of the epitope on glucocerebrosidase... [ABSTRACT FROM AUTHOR]
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KW  - TISSUE extracts
KW  - SPLEEN -- Physiology
KW  - IMMUNOGLOBULINS
KW  - SPHINGOLIPIDS
KW  - MONOCLONAL antibodies
N1  - Accession Number: 13919009; Aerts, Johannes M. F. G. 1 Donker-Koopman, Wilma E. 1 Van Laar, Coos 1 Brul, Stanley 1 Murray, Gary J. 2 Wenger, David A. 3 Barranger, John A. 2 Tager, Joseph M. 1 Schram, André W. 1; Affiliation:  1: Laboratory of Biochemistry, University of Amsterdam  2: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Diseases and Stroke, National Institutes of Health, Bethesda, Maryland  3: Department of Pediatrics C233, University of Colorado School of Medicine, Denver; Source Info: 3/16/87, Vol. 163 Issue 3, p583; Subject Term: TISSUE extracts; Subject Term: SPLEEN -- Physiology; Subject Term: IMMUNOGLOBULINS; Subject Term: SPHINGOLIPIDS; Subject Term: MONOCLONAL antibodies; Number of Pages: 7p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Mattson, Margaret E.
AU  - Pollack, Earl S.
AU  - Cullen, Joseph W.
T1  - What Are the Odds that Smoking Will Kill You?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/04//
VL  - 77
IS  - 4
M3  - Article
SP  - 425
EP  - 431
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We calculated the long-term risks of death from smoking for individuals of various ages and smoking status in terms of the excess mortality contributed by smoking, over and above the baseline mortality from the same diseases caused by factors other than smoking using standard life table procedures. Since mortality data for specific smoking categories were available only From prospective studies in the late 1950s, we scaled these to the 1982 mortality levels. We assumed, for lung cancer, that the death rates for nonsmokers have not changed and, for other smoking-related diseases, that the risks of death for smokers relative to those for nonsmokers have not changed since the 1950s. Probabilities that result from alternative assumptions were also investigated and are presented. As many as one-third of heavy smokers age 35 will die before age 85 of diseases caused by their smoking. The probabilities of death from smoking when compared with other causes may be persuasive as public education tools. Their effective use for this purpose is affected not only by the deficiencies in the public's factual knowledge of the magnitude of the risks from smoking, but also by numerous apparent misconceptions relating to the interpretation of risk information. Risk data should be presented to the public in a manner thru clarifies these misconceptions and facilitates their understanding of the overwhelming risk imposed by smoking. (Am J Public Health 1987; 77:425-431.) [ABSTRACT FROM AUTHOR]
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KW  - SMOKING
KW  - ORAL habits
KW  - LUNGS -- Cancer
KW  - MORTALITY -- Statistics
KW  - HEALTH risk assessment
KW  - PUBLIC health
KW  - HEALTH & welfare funds
KW  - HEALTH status indicators
KW  - PREVENTIVE medicine
N1  - Accession Number: 4949557; Mattson, Margaret E. 1 Pollack, Earl S. Cullen, Joseph W.; Affiliation:  1: Special Assistant for Research, Division of Cancer Prevention and Control, National Cancer Institute, Building 31, Room 4A46, 9000 Rockville Pike, Bethesda, MD 20892; Source Info: Apr87, Vol. 77 Issue 4, p425; Subject Term: SMOKING; Subject Term: ORAL habits; Subject Term: LUNGS -- Cancer; Subject Term: MORTALITY -- Statistics; Subject Term: HEALTH risk assessment; Subject Term: PUBLIC health; Subject Term: HEALTH & welfare funds; Subject Term: HEALTH status indicators; Subject Term: PREVENTIVE medicine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Albanes, Demetrius
AU  - Jones, D. Yvonne
AU  - Micozzi, Marc S.
AU  - Mattson, Margaret E.
T1  - Associations between Smoking and Body Weight in the US Population: Analysis of NHANES II.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/04//
VL  - 77
IS  - 4
M3  - Article
SP  - 439
EP  - 444
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Recent recommendations for increases in desirable body weights are based upon studies which did not consider the potential confounding effect of cigarette consumption on body weight. We investigated the relation between tobacco use and several anthropometric measurements in 12.103 men and women 19-74 years of age in the United States examined between 1976 and 1980 during the Second National Health and Nutrition Examination Survey (NHANES II). Cigarette smokers weighed less (mean +/standard error = 69.8 +/- 0.2 kg) and were leaner (body mass index (weight (kg)/height (m)²) = 24.6 +/- 0.1) than nonsmokers (72.5 +/- 0.2 kg and 25.7 +/- 0.1, respectively), controlling for age and sex. Body leanness increased with the duration (but not intensity) of smoking. Ex-smokers were not heavier or fatter than nonsmokers, and these groups experienced similar weight gain after age 25 (approximately 6 kg in men, 9 kg in women), while current smokers gained substantially less weight (3.5 kg in men, 5.4 kg in women). Compared to nonsmokers, former and current smokers were also slightly taller, Most of these associations were evident in both sexes and all ages evaluated, and were not explained by differences in caloric intake, physical activity, illness, or socioeconomic status, Our findings suggest that the increased mortality observed among lean individuals in previous studies may have been due to smoking rather than leanness per se, and that as a result, currently accepted desirable body weights may be overestimated. (Am J Public Health 1987: 77:439-444.) [ABSTRACT FROM AUTHOR]
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KW  - HEALTH surveys
KW  - BODY weight -- Regulation
KW  - CIGARETTE smokers
KW  - NICOTINE addiction
KW  - SMOKING
KW  - BODY mass index
KW  - WEIGHT measurement
KW  - PUBLIC health -- United States
KW  - UNITED States
N1  - Accession Number: 4949559; Albanes, Demetrius 1 Jones, D. Yvonne 1 Micozzi, Marc S. 1 Mattson, Margaret E. 1; Affiliation:  1: Cancer Prevention Studies Branch, and Office of the Director, Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Apr87, Vol. 77 Issue 4, p439; Subject Term: HEALTH surveys; Subject Term: BODY weight -- Regulation; Subject Term: CIGARETTE smokers; Subject Term: NICOTINE addiction; Subject Term: SMOKING; Subject Term: BODY mass index; Subject Term: WEIGHT measurement; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - GEN
AU  - Feldman, A
T1  - High output quality with quick input of chemical structures
JO  - Chemical Information Bulletin
JF  - Chemical Information Bulletin
Y1  - 1987///Sum
VL  - 39
IS  - 2
M3  - Article
SP  - 46
EP  - 46
SN  - 03641929
AB  - To avoid coding errors, chemical structures are usually entered into a computer in graphic form. To increase speed, such diagrams may be distorted. In the NCI system--which the author believes to be the fastest--distortion occurs because of the requirements that all bonds fit within multiples of character spaces, and that Luhn dots represent carbon atoms in rings. While such diagrams are suitable for error checking, they cannot be used in publications. To achieve a traditional, esthetically pleasing output, the author has embedded a conversion algorithm in the routines that format hard-copy output. The algorithm removes the Luhn dots by extending the bonds, and translates atoms and bonds from the original grid to a finer one. The illustrations show the appearance of a structure following input and as output. Under this transformation, any implied stereochemistry is retained.
KW  - Chemical data
KW  - Encoding
KW  - Input
KW  - Output
N1  - Accession Number: ISTA2202842; Feldman, A 1; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: Sum 1987, Vol. 39 Issue 2, p46; Note: Update Code: 2200; Author-Supplied Keyword: Chemical data; Author-Supplied Keyword: Encoding; Author-Supplied Keyword: Input; Author-Supplied Keyword: Output; Number of Pages: 1p; Document Type: Article
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TY  - JOUR
AU  - Mizuma, H.
AU  - Zolla-Pazner, Susan
AU  - Litwin, S.
AU  - Wafaa El-Sadr
AU  - Sharpe, Sandra
AU  - Zehr, B.
AU  - Weiss, S.
AU  - Saxinger, W.C.
AU  - Marmor, M-
T1  - Serum IgD elevation is an early marker of B cell activation during infection with the human immunodeficiency viruses.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/04//
VL  - 68
IS  - 1
M3  - Article
SP  - 5
EP  - 14
PB  - Wiley-Blackwell
SN  - 00099104
AB  - IgD levels in individuals infected with the human immunodeficiency viruses (HIV) were studied as a means of monitoring the character and timing of B cell activation in individuals with this infection. Significantly increased levels of IgD were characteristic of homosexual men who were HIV seropositive but asymptomatic or mildly symptomatic. The hyper IgD globulinaemia became progressively more pronounced in patients with increasingly severe infection and reached its most marked level in patients with AID Sreiated complex (ARC), In ARC patients, IgD levels were increased 8-8-fold above normal which was disproportionately greater than the 2 4-fold increase in IgG, the 1-8- fold increase in IgA and the 1-6-fold increase in IgM. IgD levels declined in AIDS patients (although remained elevated compared to controls). The data suggest that an unusual type of B cell activation is responsible for the unique pattern of hypergammaglobulinaemia seen in this disease and that the B cell activation occurs early in the pathogenesis of HIV infection, often before development of symptoms, and continues throughout the course of infection. [ABSTRACT FROM AUTHOR]
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KW  - SERUM
KW  - B cells
KW  - HIV (Viruses)
KW  - AIDS (Disease)
KW  - HYPERGAMMAGLOBULINEMIA
KW  - LYMPHOCYTES
KW  - AIDS
KW  - HIV
KW  - IgD
KW  - polyclonal B cell activation
N1  - Accession Number: 16166910; Mizuma, H. 1,2 Zolla-Pazner, Susan 1,2 Litwin, S. 3 Wafaa El-Sadr 4,5 Sharpe, Sandra 2 Zehr, B. 3 Weiss, S. 6 Saxinger, W.C. 6 Marmor, M- 7; Affiliation:  1: Laboratory, New York Veterans Administration Medical Center, New York, NY.  2: Department of Pathology, New York University Medical Center, New York, NY.  3: Guthrie Research Institute, Sayre, PA.  4: Medical Services, New York Veterans Administration Medical Center, New York, NY.  5: Department of Medicine, New York University Medical Center, New York, NY.  6: National Cancer Institute, Bethesda, MD, USA.  7: Department of Environmental Medicine, New York University Medical Center, New York, NY.; Source Info: Apr1987, Vol. 68 Issue 1, p5; Subject Term: SERUM; Subject Term: B cells; Subject Term: HIV (Viruses); Subject Term: AIDS (Disease); Subject Term: HYPERGAMMAGLOBULINEMIA; Subject Term: LYMPHOCYTES; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: HIV; Author-Supplied Keyword: IgD; Author-Supplied Keyword: polyclonal B cell activation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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TY  - JOUR
AU  - Jonsson, Lisbeth M. V.
AU  - Murray, Gary J.
AU  - Sorrell, Susan H.
AU  - Strijland, Anneke
AU  - Aerts, Johannes F. G. M.
AU  - Ginns, Edward I.
AU  - Barranger, John A.
AU  - Tager, Joseph M.
AU  - Schram, André W.
T1  - Biosynthesis and maturation of glucocerebrosidase in Gaucher fibroblasts.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/04//4/1/87
VL  - 164
IS  - 1
M3  - Article
SP  - 171
EP  - 179
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The biosynthesis and maturation of glucocerebrosidase were studied in fibroblasts from patients with the neurological and non-neurological forms of Gaucher disease and in control cells. In control fibroblasts the precursor of glucocerebrosidase (62–63 kDa), observed after a short pulse with [35S]methionine, was converted during the chase period to a 66-kDa intermediate form and, finally, to the 59-kDa mature protein. In fibroblasts from patients with the non-neurological phenotype of Gaucher disease (type 1) the same biosynthetic forms were seen as in control fibroblasts. These biosynthetic forms correspond to the three-banded pattern seen in control and Gaucher type 1 fibroblast extracts analysed by the immunoblotting procedure, or after electrophoresis and fluorography of extracts of such fibroblasts cultured for 5 days with [14C]leucine. The 59-kDa protein seen in type 1 fibroblasts was unstable and disappeared after a prolonged chase; this disappearance was not observed when the cells were grown in the presence of leupeptin. In fibroblasts from patients with the neurological forms of Gaucher disease (types 2 and 3) the 62.5-kDa precursor of glucocerebrosidase was present in near-normal amounts after a short pulse, but the 59-kDa form was not detected even when cells were cultured with leupeptin. These results are in accordance with the absence of the 59-kDa band in immunoblots of types 2 and 3 fibroblast extracts. Culturing of type 1, type 2 and type 3 Gaucher fibroblasts in the presence of leupeptin led to an increase in the activity of glucocerebrosidase. [ABSTRACT FROM AUTHOR]
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KW  - BIOSYNTHESIS
KW  - ORGANIC synthesis (Chemistry)
KW  - GAUCHER'S disease
KW  - SPHINGOLIPIDOSES
KW  - FIBROBLASTS
KW  - CONNECTIVE tissue cells
N1  - Accession Number: 13669616; Jonsson, Lisbeth M. V. 1,2 Murray, Gary J. 2 Sorrell, Susan H. 2 Strijland, Anneke 1 Aerts, Johannes F. G. M. 1 Ginns, Edward I. 2 Barranger, John A. 2 Tager, Joseph M. 1 Schram, André W. 1; Affiliation:  1: Laboratory of Biochemistry, University of Amsterdam  2: Molecular and Medical Genetics Section, Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: 4/1/87, Vol. 164 Issue 1, p171; Subject Term: BIOSYNTHESIS; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: GAUCHER'S disease; Subject Term: SPHINGOLIPIDOSES; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 9p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Hattori, Y.
AU  - Siraganian, R. P.
T1  - Rapid phosphorylation of a 92,000 MW protein on activation of rat basophilic leukaemia cells for histamine release.
JO  - Immunology
JF  - Immunology
Y1  - 1987/04//
VL  - 60
IS  - 4
M3  - Article
SP  - 573
EP  - 578
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Many cellular functions are modulated by phosphorylation of proteins. The IgE- or ionophore-mediated activation of rat basophilic leukaemia cells (RBL-2H3) was accompanied by the prominent phosphorylation of a 92,000 molecular weight (MW) cellular component. The degree of phosphorylation of this component correlated with the extent of histamine release from the cells. This phosphorylation was rapid, reaching a maximum 2–5 min following the addition of the ionophore or antigen, and decreasing to background by 30 min. In contrast, histamine release is a much slower process. Although the phosphorylation required the presence of Ca2+ in the medium, it was not inhibited by La3+, which blocks the stimulated entry of Ca2+. Therefore, the stimulation of a Ca2+-dependent kinase is an early event in the activation of the rat basophilic leukaemia cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUKEMIA
KW  - CHEMICAL reactions
KW  - PHOSPHORYLASES
KW  - PHOSPHORYLATION
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 14016513; Hattori, Y. 1 Siraganian, R. P. 1; Affiliation:  1: Clinical Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr87, Vol. 60 Issue 4, p573; Subject Term: LEUKEMIA; Subject Term: CHEMICAL reactions; Subject Term: PHOSPHORYLASES; Subject Term: PHOSPHORYLATION; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Yancey, Kim B.
AU  - Bielory, Leonard
AU  - Wright, Ralph
AU  - Young, Neal
AU  - Frank, Michael M.
AU  - Lawley, Thomas J.
T1  - Patients With Bone Marrow Failure Demonstrate Decreased Cutaneous Reactivity to Human C5a.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/04//
VL  - 88
IS  - 4
M3  - Article
SP  - 388
EP  - 392
SN  - 0022202X
AB  - In vivo studies have shown that human C5a, a potent complement-derived anaphylatoxin and chemoattractant, produces immediate inflammatory reactions following intradermal injection in human skin. At concentrations within its potential physiologic range, intradermal injection of C5a elicits immediate wheal and flare reactions, increased vascular permeability, mast cell degranulation, and neutrophil-rich infiltrates. To assess the relative contribution of interacting cellular elements to C5a-induced inflammation in normal human skin, purified human C5a was tested intradermally in 8 patients with bone marrow failure (BMF). Reactions to C5a in patients with BMF were compared with responses at identical test sites in healthy volunteers and other patients with cutaneous disorders. Patients with BMF demonstrated significantly less wheal and flare reactivity following intradermal injection of C5a than controls (p < 0.05 and < 0.02, respectively). In these studies, patients with the greatest cytopenia generally showed the least cutaneous reactivity to human C5a. Biopsies of C5a test sites in patients with BMF revealed an absence of leukocytes in marked contrast to neutrophil-rich infiltrates observed at test sites in healthy volunteers. Avidin-fluorescein and/or Giemsa staining of skin biopsies revealed no difference between the number of dermal mast cells in patients with BMF and samples of normal human skin. In addition, skin test studies with histamine (2 μg) and morphine (5 μg) performed to assess cutaneous vascular and mast cell responsiveness in patients with BMF, normal volunteers, and controls with rhinitis revealed no significant differences in cutaneous reactivity to these pharmacologic agents. These in vivo studies demonstrate that patients with BMF specifically exhibit decreased cutaneous reactivity to human C5a and suggest that neutrophils make an important and an immediate contribution to inflammatory responses elicited by this anaphylatoxin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BONE marrow
KW  - IMMUNE system
KW  - INFLAMMATION
KW  - MAST cells
KW  - NEUTROPHILS
KW  - PATIENTS
N1  - Accession Number: 12469445; Yancey, Kim B. 1 Bielory, Leonard 2 Wright, Ralph 3 Young, Neal 2 Frank, Michael M. 4 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National institutes of Health  2: Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institute of Health  3: Nursing Department, Clinical Center, National Institute of Health  4: Laboratory of Clinical Investigation, National Institute of Allergy and Infections Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr87, Vol. 88 Issue 4, p388; Subject Term: BONE marrow; Subject Term: IMMUNE system; Subject Term: INFLAMMATION; Subject Term: MAST cells; Subject Term: NEUTROPHILS; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469445
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12469445&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Krey, Anne K.
AU  - Moshell, Allan N.
AU  - Dayton, Delbert H.
AU  - Sawyer, Roger H.
AU  - Holbrook, Karen A.
T1  - Morphogenesis and Malformations of the Skin NICHD/NIADDK Research Workshop.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/04//
VL  - 88
IS  - 4
M3  - Article
SP  - 464
EP  - 473
SN  - 0022202X
AB  - Developmentally caused skin malformations constitute a spectrum of birth defects, some of which can be recognized prenatally by morphologic or biochemical means. The number of prenatally diagnosable skin diseases could be greatly expanded with an increased understanding of the molecular and cellular bases of skin development and the mechanisms that result in the generation of skin defects. The National Institute of Child Health and Human Development and the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, therefore, sponsored a workshop that recommended basic biologic studies combined with clinical investigations of normal and abnormal cutaneous development set forth in this article. Investigations resulting from these research recommendations are intended to contribute to the knowledge that should aid in the prevention of developmentally caused skin deformities. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - MORPHOGENESIS
KW  - BIOCHEMISTRY
KW  - SKIN diseases
KW  - KIDNEYS
KW  - DIABETES
N1  - Accession Number: 12469911; Krey, Anne K. 1 Moshell, Allan N. 1 Dayton, Delbert H. 1 Sawyer, Roger H. 1 Holbrook, Karen A. 1; Affiliation:  1: National Institute of Child Health and Human Development/National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, U.S.A.; Source Info: Apr87, Vol. 88 Issue 4, p464; Subject Term: SKIN; Subject Term: MORPHOGENESIS; Subject Term: BIOCHEMISTRY; Subject Term: SKIN diseases; Subject Term: KIDNEYS; Subject Term: DIABETES; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469911
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12469911&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06447-014
AN  - 2006-06447-014
AU  - Crawley, Jacqueline N.
T1  - Drugs for Undergraduates.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/04//
VL  - 32
IS  - 4
SP  - 329
EP  - 330
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06447-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Crawley, Jacqueline N.; Unit on Behavioral Neuropharmacology, Clinical Neurosdence Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Benzodiazepines; Psychopharmacology. Minor Descriptor: Caffeine; Drugs; Neuroanatomy; Neurophysiology; Nicotine; Opiates. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: McKim, William A. Drugs and Behavior: An Introduction to Behavioral Pharmacology=Englewood Cliffs, NJ: Prentice-Hall, 1986. 288 pp. $20.95 paperback; 1986. Page Count: 2. Issue Publication Date: Apr, 1987. 
AB  - Reviews the book, Drugs and Behavior: An Introduction to Behavioral Pharmacology by William A. McKim (1986). This book incorporates some, but not all, of the exciting advances in psychopharmacology, in a simple, appealing format. The first half of the book introduces basic principles of behavioral pharmacology. The chapter summarizing neuroanatomy, neurophysiology, and neuropharmacology is too short, however, requiring a companion book or an additional neuroscience course. The second half of the book contains intensive chapters on individual drugs of particular interest: alcohol, barbiturates, benzodiazepines, tobacco, caffeine, opiates, cannabis, hallucinogens, stimulants, and antidepressants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drugs
KW  - behavioral pharmacology
KW  - neuroanatomy
KW  - neurophysiology
KW  - neuropharmacology
KW  - benzodiazepines
KW  - tobacco
KW  - caffeine
KW  - opiates
KW  - 1987
KW  - Benzodiazepines
KW  - Psychopharmacology
KW  - Caffeine
KW  - Drugs
KW  - Neuroanatomy
KW  - Neurophysiology
KW  - Nicotine
KW  - Opiates
KW  - 1987
U2  - McKim, William A. (1986); Drugs and Behavior: An Introduction to Behavioral Pharmacology; Englewood Cliffs, NJ: Prentice-Hall, 1986. 288 pp. $20.95 paperback
DO  - 10.1037/026981
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06447-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rhoads, George G.
T1  - Reliability of diet measures as chronic disease risk factors.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/05//
VL  - 45
IS  - 5
M3  - Article
SP  - 1073
EP  - 1079
SN  - 00029165
AB  - The article focuses on the relation of diet to the development of chronic disease, with special reference to coronary heart disease. In experimental studies the effect of dietary saturated fatty acid intake on serum low density lipoprotein (LDL) level has been amply confirmed. It mentions about methods used to study the impact of diet on health.
KW  - Diet
KW  - Nutrition -- Requirements
KW  - Food -- Composition
KW  - Nutrition -- Evaluation
KW  - Coronary heart disease
N1  - Accession Number: 91253854; Rhoads, George G. 1; Affiliations: 1: Epidemiology and Biometry Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Issue Info: May1987, Vol. 45 Issue 5, p1073; Subject Term: Diet; Subject Term: Nutrition -- Requirements; Subject Term: Food -- Composition; Subject Term: Nutrition -- Evaluation; Subject Term: Coronary heart disease; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Richters, John E.
T1  - Infant-Mother Attachment: The Origins and Developmental Significance of Individual Differences in Strange Situation Behavior (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1987/05//May/Jun87
VL  - 75
IS  - 3
M3  - Book Review
SP  - 318
EP  - 318
SN  - 00030996
AB  - Reviews the book `Infant-Mother Attachment: The Origins and Developmental Significance of Individual Differences in Strange Situation Behavior,' by Michael E. Lamb, Ross A. Thompson, William Gardner and Eric L. Charnov.
KW  - Lamb, Michael E.
KW  - Thompson, Ross A.
KW  - Gardner, William
KW  - Charnov, Eric L.
KW  - Infant-Mother Attachment (Book)
N1  - Accession Number: 11231167; Richters, John E. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: May/Jun87, Vol. 75 Issue 3, p318; Reviews & Products: Infant-Mother Attachment (Book); People: Lamb, Michael E.; People: Thompson, Ross A.; People: Gardner, William; People: Charnov, Eric L.; Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Boutin, B.
AU  - Wagner, D. K.
AU  - Nelson, D. L.
T1  - Analysis of CD3 antigen expression in patients with ataxia-telangiectasia.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/05//
VL  - 68
IS  - 2
M3  - Article
SP  - 320
EP  - 330
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The expression of CD3 molecules by the lymphocytes of five patients with ataxia-telangiectasia was examined using the murine monoclonal antibody OKT3. By immunofluorescent staining, fewer of the patients' peripheral blood mononuclear cells and purified T cells expressed CD3 compared with normals. The proliferative response of the patients' cells to 0KT3 was also less than normal. However, the mononuclear cells from all five patients produced lL-2 after OKT3 stimulation: in four patients IL-2 was normal, while one patient produced greater than normal levels. While the expression of cellular IL- 2 receptors and the release of these receptors into culture supernatants was generally less in ataxia-telangiectasia patients. The levels of receptor expression were not significantly less than normal. As analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis. the CD 3 molecules from ataxia-telangiectasia patients' lymphocytes were no different from those of normal individuals. These results suggest that patients with ataxiatclangiectasia have structurally normal CD3 molecules which may be used to activate cells normally for some but not all T cell functions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - LYMPHOCYTES
KW  - TELANGIECTASIA
KW  - T cells
KW  - GEL electrophoresis
KW  - MOLECULAR cloning
KW  - LEUCOCYTES
KW  - ataxia-telangiectasia
KW  - CD3
KW  - interleukin 2.
N1  - Accession Number: 16171620; Boutin, B. 1 Wagner, D. K. 1 Nelson, D. L. 1; Affiliation:  1: Imnnmophysiology Section. Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA.; Source Info: May1987, Vol. 68 Issue 2, p320; Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: TELANGIECTASIA; Subject Term: T cells; Subject Term: GEL electrophoresis; Subject Term: MOLECULAR cloning; Subject Term: LEUCOCYTES; Author-Supplied Keyword: ataxia-telangiectasia; Author-Supplied Keyword: CD3; Author-Supplied Keyword: interleukin 2.; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Malbran, A.
AU  - Frank, M. M.
AU  - Fries, L. F.
T1  - Interactions of monomeric IgG bearing covalently bound C3b with polymorphonuclear leucocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1987/05//
VL  - 61
IS  - 1
M3  - Article
SP  - 15
EP  - 20
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The interactions of monomeric IgG, monomeric C3b, dimeric C3b, and C3b covalently bound to IgG (C3b-IgG) with neutrophils were examined. C3b-IgG heterodimers exhibited an increased affinity of binding to neutrophils, relative to C3b, both at half normal ionic strength (five-fold enhancement) and at normal ionic strength (six-fold enhancement). Binding of monomeric IgG to neutrophils was barely detectable and did not permit direct measurements of affinity in our assay conditions. The increased affinity of C3b-IgG for neutropbils was the result of divalent interactions with CR1, the C3b receptor, and the Fcγ receptor of the cells, as could be demonstrated by competition studies using unlabelled IgG in the medium or monoclonal antibodies against the neutrophil Fcγ receptor. This double receptor-ligand interaction allowed C3b-IgG to bind to the ceils not only at normal ionic strength, but also in the presence of a 315-fold excess of IgG (near plasma concentration)- conditions that would preclude the binding of C3b or IgG alone. Furthermore, this interaction leads to the internalization of the C3b-IgG complex by the cells. C3b-IgG is internalized with kinetics similar to those found using dimeric C3b, with resting cells demonstrating a slow initial phase, which is accelerated by phorbol ester activation in both cases. Uptake of the homodimeric C3b was greater at 15 min than that of heterodimeric C3b-IgG, but both were significantly greater than that of monomer C3b, which showed no net internalization. The physiological implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEUTROPHILS
KW  - MEDICAL sciences
KW  - CELLULAR recognition
KW  - MONOCLONAL antibodies
N1  - Accession Number: 13504405; Malbran, A. 1 Frank, M. M. 1 Fries, L. F. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May87, Vol. 61 Issue 1, p15; Subject Term: NEUTROPHILS; Subject Term: MEDICAL sciences; Subject Term: CELLULAR recognition; Subject Term: MONOCLONAL antibodies; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06448-016
AN  - 2006-06448-016
AU  - Jones, Barbara Pendleton
T1  - Advise and Dissent.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/05//
VL  - 32
IS  - 5
SP  - 431
EP  - 432
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06448-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Jones, Barbara Pendleton; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Correction Date: 20151207. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Neuropsychological Assessment; Neuropsychology. Minor Descriptor: Test Battery. Classification: Neuropsychological Assessment (2225). Population: Human (10). Reviewed Item: Incagnoli, Theresa (Ed); Goldstein, Gerald (Ed); Golden, Charles J. (Ed). Clinical Application of Neuropsychological Test Batteries=New York: Plenum Press, 1986. 408 pp. $42.50; 1986. References Available: Y. Page Count: 2. Issue Publication Date: May, 1987. 
AB  - Reviews the book, Clinical Application of Neuropsychological Test Batteries by Theresa Incagnoli, Gerald Goldstein, and Charles J. Golden (Eds.) (1986). This volume grew out of a Veterans Administration (VA) conference that was originally intended as a forum for debating which of the two most commonly used neuropsychological test batteries, the venerable Halstead-Reitan Neuropsychological Test Battery (HRB) or the newer Luria-Nebraska Neuropsychological Test Battery (LNNB), would prevail within the VA system. To the extent that the book speaks to both sides of controversy regarding debate within current clinical neuropsychology, that is, the debate over the relative merits of the fixed-battery approach versus the individualized test selection approach., it represents a refreshing change from recent one-sided approaches disguised as comprehensive treatments. This is a volume that will be of more interest to relative newcomers to neuropsychology than to experienced practitioners in the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuropsychological test batteries
KW  - clinical neuropsychology
KW  - 1987
KW  - Neuropsychological Assessment
KW  - Neuropsychology
KW  - Test Battery
KW  - 1987
U2  - Incagnoli, Theresa (Ed); Goldstein, Gerald (Ed); Golden, Charles J. (Ed). (1986); Clinical Application of Neuropsychological Test Batteries; New York: Plenum Press, 1986. 408 pp. $42.50; 0-306-42045-7.
DO  - 10.1037/027121
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06448-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06448-043
AN  - 2006-06448-043
AU  - Hadley, Suzanne W.
T1  - What's Good About Psychopathology?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/05//
VL  - 32
IS  - 5
SP  - 462
EP  - 462
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06448-043. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hadley, Suzanne W.; Extramural Policy Branch, Division of Extramural Activities, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychopathology; Society. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Pallone, Nathaniel J. On the Social Utility of Psychopathology: A Deviant Majority and its Keepers?=New Brunswick, NJ: Transaction Books, 1986. 79 pp. $24.95; 1986. Page Count: 1. Issue Publication Date: May, 1987. 
AB  - Reviews the book, On the Social Utility of Psychopathology: A Deviant Majority and its Keepers? by Nathaniel J. Pallone (see record [rid]1986-97533-000[/rid]). This is a remarkable little book. The author's theses are very clear. He seeks to establish that psychopathology is useful to society, indeed, that psychopathology is essential for the maintenance of society. Furthermore, he suggests that it is this vital functional relationship between society and psychopathology that is responsible for the continued existence of psychopathology, and for the endlessly proliferating assemblage of institutions and professions that ostensibly are devoted to healing the mentally ill. The book would make an excellent resource for a graduate seminar on the ethics and philosophy of mental health care Despite its outlandish price, I recommend it with some enthusiasm to interested readers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychopathology
KW  - society
KW  - mentally ill
KW  - 1987
KW  - Psychopathology
KW  - Society
KW  - 1987
U2  - Pallone, Nathaniel J. (1986); On the Social Utility of Psychopathology: A Deviant Majority and its Keepers?; New Brunswick, NJ: Transaction Books, 1986. 79 pp. $24.95
DO  - 10.1037/027148
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06448-043&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06448-047
AN  - 2006-06448-047
AU  - Rapoport, Judith L.
T1  - What Happens to Hyperactive Children?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/05//
VL  - 32
IS  - 5
SP  - 465
EP  - 466
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06448-047. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rapoport, Judith L.; Child Psychiatry Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Development; Hyperkinesis. Minor Descriptor: Drug Therapy. Classification: Developmental Disorders & Autism (3250). Population: Human (10). Reviewed Item: Weiss, Gabrielle; Hechtman, Lily Trokenberg. Hyperactive Children Grown Up: Empirical Findings and Theoretical Considerations=New York: Guilford Press, 1986. 367 pp. $32.50; 1986. References Available: Y. Page Count: 2. Issue Publication Date: May, 1987. 
AB  - Reviews the book, Hyperactive Children Grown Up: Empirical Findings and Theoretical Considerations by Gabrielle Weiss and Lily Trokenberg Hechtman (1986). In this book authors convey their formidable experience in studying and following a group of more than 100 hyperactive children from grade school years to young adulthood. This is a lovely book. But, to do it justice, one must be clear about what the authors intended to do, which is to convey in detailed and leisurely style an immense body of data accumulated over 15 years. This is the first major prospective, controlled follow-up study of hyperactive children. The authors have a lucid style, and their open, honest presentation of data is exemplary. The most interesting findings, and unique to this study, are those resulting from the careful examination of the long-term effects of stimulant drug treatment on ultimate functioning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hyperactive children
KW  - stimulant drug treatment
KW  - longterm develoment
KW  - 1987
KW  - Human Development
KW  - Hyperkinesis
KW  - Drug Therapy
KW  - 1987
U2  - Weiss, Gabrielle; Hechtman, Lily Trokenberg. (1986); Hyperactive Children Grown Up: Empirical Findings and Theoretical Considerations; New York: Guilford Press, 1986. 367 pp. $32.50; 0-89862-661-7.
DO  - 10.1037/027152
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06448-047&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Gierschik, Peter
AU  - Sidiropoulos, Dimitrios
AU  - Jakobs, Karl H.
AU  - Spiegel, Allen
T1  - Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/05/15/
VL  - 165
IS  - 1
M3  - Article
SP  - 185
EP  - 194
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Bovine peripheral neutrophils contain high levels of a 40-kDa pertussis toxin substrate, which was found highly enriched in a light membrane fraction upon subcellular fractionation of neutrophil homogenates. The 40kDa pertussis toxin substrate, referred to as &alphan, was purified to near homogeneity from this fraction by sequential ion-exchange, gel-filtration and hydrophobic chromatography. Purified αn was shown to interact with βγ subunits, undergo ADP-ribosylation by pertussis toxin, and bind guanine nucleotides with high affinity. The mobility of purified αn on SDS/polyacrylamide gels was intermediate between those of the α subunits of Gi and Go, purified from bovine brain, and slightly lower than the mobility of the α subunit of transducin (Gt). Several polyclonal antisera against the α subunits of bovine Gtt and Go did not react with αn on immunoblots. CW 6, a polyclonal antiserum reactive against the bovine αi, reacted only minimally with αn. These results suggest that the major pertussis toxin substrate of bovine neutrophils, designated Gn, is structurally different from previously identified pertussis toxin substrates and may represent a novel gnanine-nucleotide-binding protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BACTERIAL toxins
KW  - NEUTROPHILS
KW  - GRANULOCYTES
KW  - COLLOIDS
KW  - CHROMATOGRAPHIC analysis
KW  - CELLULAR signal transduction
N1  - Accession Number: 13813336; Gierschik, Peter 1 Sidiropoulos, Dimitrios 1 Jakobs, Karl H. 1 Spiegel, Allen 2; Affiliation:  1: Pharmakologisches Institut, Universität Heidelberg  2: Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 5/15/87, Vol. 165 Issue 1, p185; Subject Term: BACTERIAL toxins; Subject Term: NEUTROPHILS; Subject Term: GRANULOCYTES; Subject Term: COLLOIDS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CELLULAR signal transduction; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 4 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
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ER  - 

TY  - JOUR
AU  - TENNANT, RAYMOND W.
AU  - MARGOLIN, BARRY H.
AU  - SHELBY, MICHAEL D.
AU  - ZEIGER, ERROL
AU  - HASEMAN, JOSEPH K.
AU  - SPALDING, JUDSON
AU  - CASPARY, WILLIAM
AU  - RESNICK, MICHAEL
AU  - STASIEWICZ, STANLEY
AU  - ANDERSON, BETH
AU  - MINOR, ROBERT
T1  - Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetc Toxicity Assays.
JO  - Science
JF  - Science
Y1  - 1987/05/22/
VL  - 236
IS  - 4804
M3  - Article
SP  - 933
EP  - 941
SN  - 00368075
AB  - Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents. These assays were mutagenesis in Salmonella and mouse lymphoma cells and chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells. Seventy-three chemicals recently tested in 2-year carcinogenicity studies conducted by the National Cancer Institute and the National Toxicology Program were used in this evaluation. Test results from the four in vitro assays did not show significant differences in individual cobcordance with the rodent carcinogenicity results; the concordance of each assay was approximately 60 percent. Within the limits of this study there was no evidence of complementarity among the four assays, and no battery of tests constructed from these assays improved substantially on the overall performance of the Salmonella assay. The in vitro assays which represented a range of three cell types and four end points did show substantial agreement among themselves, indicating that chemicals positive in one in vitro assay tended to be positive in the other in vitro assays. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84692489; TENNANT, RAYMOND W. 1 MARGOLIN, BARRY H. 2 SHELBY, MICHAEL D. 1 ZEIGER, ERROL 1 HASEMAN, JOSEPH K. 2 SPALDING, JUDSON 1 CASPARY, WILLIAM 1 RESNICK, MICHAEL 1 STASIEWICZ, STANLEY 1 ANDERSON, BETH 1 MINOR, ROBERT 3; Affiliation:  1: Cellular and Genetic Toxicology Branch, Toxicology Research and Testing Divisioo, National Institute of Environmental Health Sciences, Research Tnangle Park, NC 27709  2: Statistics and Biomathematics Branch, Biometry and Risk Assessment Division, National Institute of Environmental Health Sciences, Research Trianglc Park, NC 27709  3: Information Systems and Networks Corporation, Research Triangle Park, NC 27709; Source Info: 5/22/1987, Vol. 236 Issue 4804, p933; Number of Pages: 9p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - SNAPPER, CLIFFORD M.
AU  - PAUL, WILLIAM E.
T1  - Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production.
JO  - Science
JF  - Science
Y1  - 1987/05/22/
VL  - 236
IS  - 4804
M3  - Article
SP  - 944
EP  - 947
SN  - 00368075
AB  - Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF- 1 has powerful effects in promoting switching to the expression of IgGl and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-γ as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotypc responses. The effects ofIFN-γ and BSF-1 on isotype expression are independent. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 84692491; SNAPPER, CLIFFORD M. 1 PAUL, WILLIAM E. 1; Affiliation:  1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/22/1987, Vol. 236 Issue 4804, p944; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Jones, D. Yvonne
AU  - Judd, Joseph T.
AU  - Taylor, Philip R.
AU  - Campbell, William S.
AU  - Nair, Padmanabhan P.
T1  - Influence of caloric contribution and saturation of dietary fat on plasma lipids in premenopausal women.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/06//
VL  - 45
IS  - 6
M3  - Article
SP  - 1451
EP  - 1456
SN  - 00029165
AB  - Total cholesterol, HDL cholesterol, and triglycerides were measured in 31 pre-menopausal women randomized into one of two diet groups: one diet with a P:S ratio of 1.0 and one diet with a P:S ratio of 0.3. Both groups were fed a high-fat diet (40% of energy from fat) for four menstrual cycles per subject followed by a similar interval on a low-fat diet (20% of energy from fat). Changing from the high-fat to the low-fat diet resulted in a nonsignificant mean decrease of 7% in total cholesterol. HDL-cholesterol response to the low-fat regimen was influenced by the P:S ratio. Women in the high P:S group showed no change; mean HDL cholesterol in women in the low P:S group decreased 12%. Plasma triglycerides increased in both groups on the low-fat diet although the increase was greatest in the low P:S group. [ABSTRACT FROM AUTHOR]
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KW  - Food -- Caloric content
KW  - Dietaries
KW  - Blood plasma
KW  - Perimenopause
KW  - Lipids
KW  - Cholesterol
KW  - P:S ratio
KW  - polyunsaturated fat
KW  - triglycerides
N1  - Accession Number: 91550197; Jones, D. Yvonne 1; Judd, Joseph T. 2; Taylor, Philip R. 1; Campbell, William S. 1; Nair, Padmanabhan P. 2; Affiliations: 1: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, NIH, DHHS; 2: Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA; Issue Info: Jun1987, Vol. 45 Issue 6, p1451; Subject Term: Food -- Caloric content; Subject Term: Dietaries; Subject Term: Blood plasma; Subject Term: Perimenopause; Subject Term: Lipids; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: P:S ratio; Author-Supplied Keyword: polyunsaturated fat; Author-Supplied Keyword: triglycerides; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Bieri, John G.
T1  - Fat-Soluble Vitamins: Their Biochemistry and Applications.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/06//
VL  - 45
IS  - 6
M3  - Book Review
SP  - 1549
EP  - 1550
SN  - 00029165
KW  - Vitamin D
KW  - Nonfiction
KW  - Diplock, Anthony T.
KW  - Fat-Soluble Vitamins: Their Biochemistry & Applications (Book)
N1  - Accession Number: 91550213; Bieri, John G. 1; Affiliations: 1: National Institutes of Health Bethesda, MD 20892; Issue Info: Jun1987, Vol. 45 Issue 6, p1549; Subject Term: Vitamin D; Subject Term: Nonfiction; Reviews & Products: Fat-Soluble Vitamins: Their Biochemistry & Applications (Book); People: Diplock, Anthony T.; Number of Pages: 2p; Document Type: Book Review
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DB  - eih
ER  - 

TY  - JOUR
AU  - Parker, Douglas A.
AU  - Parker, Elizabeth S.
AU  - Hareord, Thomas C.
AU  - Farmer, Gail C.
T1  - Alcohol Use and Depression Symptoms among Employed Men and Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/06//
VL  - 77
IS  - 6
M3  - Article
SP  - 704
EP  - 707
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: A representative sample of 1,367 employed men and women in Detroit responded lo questions about drinking practices and symptoms of depression. After controlling for age, education. family income, marital status, medication use, fathers' drinking, and other variables, increased quantity of alcohol consumed per drinking occasion was associated with increased depression symptoms in the sober state among men anti women. Depression symptoms may be one of a group of not fully identified drug after-effect disorders involving psychological functioning. (Am J Public Health 1987; 77:704-707). [ABSTRACT FROM AUTHOR]
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KW  - DRINKING of alcoholic beverages
KW  - MEDICAL care surveys
KW  - INDUSTRIAL hygiene
KW  - MENTAL depression
KW  - DEPRESSION in women
KW  - DEPRESSION in men
KW  - ALCOHOLISM
KW  - DRINKING behavior
KW  - MARITAL status
KW  - ALCOHOLIC beverages
N1  - Accession Number: 4951034; Parker, Douglas A. 1 Parker, Elizabeth S. 2 Hareord, Thomas C. 3 Farmer, Gail C. 4; Affiliation:  1: Professor of Sociology. California State University, 12.50 Bellflower Blvd., Long Reach, CA 90840.  2: Research Psychologist in the Neuropsychiatric Institute at the University of California, Los Angeles.  3: Acting Director of the Bioinetry and Epidemiology Division at the National Institute on Alcohol Abuse and Alcoholism, Rockville, MD  4: Assistant Professor of Health Science and Sociology at the California State University, Long Bea; Source Info: Jun87, Vol. 77 Issue 6, p704; Subject Term: DRINKING of alcoholic beverages; Subject Term: MEDICAL care surveys; Subject Term: INDUSTRIAL hygiene; Subject Term: MENTAL depression; Subject Term: DEPRESSION in women; Subject Term: DEPRESSION in men; Subject Term: ALCOHOLISM; Subject Term: DRINKING behavior; Subject Term: MARITAL status; Subject Term: ALCOHOLIC beverages; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 312140 Distilleries; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Shern, Roald J.
AU  - Mirth, Dale B.
AU  - Emilson, Claes- Göran
AU  - Adderly, Donna D.
AU  - Bowen, William H.
T1  - Evaluation of an intraoral controlled release delivery system for fluoride in primates.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1987/06//
VL  - 15
IS  - 3
M3  - Article
SP  - 113
EP  - 116
SN  - 03015661
AB  - An intraoral delivery system designed to release 0.5 mg of fluoride per day was evaluated in short-term studies in primates. This fluoride-releasing device, bonded to the buccal surface of the maxillary right central incisor of each of six monkeys (Macaca fascicularis), produced marked elevations in saliva and plaque fluoride concentrations without increases in serum fluoride concentrations. No changes were observed in the plaque and gingival scores or the populations of various species of plaque bacteria. [ABSTRACT FROM AUTHOR]
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KW  - PRIMATES
KW  - FLUORIDES
KW  - SALIVA
KW  - INCISORS
KW  - MICROBIOLOGY -- Technique
KW  - MONKEYS
KW  - dental plaque bacteria
KW  - fluoride
KW  - intraoral device
KW  - primate
N1  - Accession Number: 12014045; Shern, Roald J. 1 Mirth, Dale B. 1 Emilson, Claes- Göran 2 Adderly, Donna D. 1 Bowen, William H. 3; Affiliation:  1: Epidemiology and Oral Disease Prevention Program National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.  2: Department of Cariology. Faculty of Odontology, University of Göteborg, Gothenburg, Sweden.  3: Department of Dental Research, University of Rochester, Rochester, NY, USA.; Source Info: Jun1987, Vol. 15 Issue 3, p113; Subject Term: PRIMATES; Subject Term: FLUORIDES; Subject Term: SALIVA; Subject Term: INCISORS; Subject Term: MICROBIOLOGY -- Technique; Subject Term: MONKEYS; Author-Supplied Keyword: dental plaque bacteria; Author-Supplied Keyword: fluoride; Author-Supplied Keyword: intraoral device; Author-Supplied Keyword: primate; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1600-0528.ep12014045
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DB  - aph
ER  - 

TY  - JOUR
AU  - Tsuji, Shoji
AU  - Martin, Brian M.
AU  - Kaslow, David C.
AU  - Migeon, Barbara R.
AU  - Choudary, Prabhakara V.
AU  - Stubbleflied, Barbara K.
AU  - Mayor, June A.
AU  - Murray, Gary J.
AU  - Barranger, John A.
AU  - Ginns, Edward I.
T1  - Signal sequence and DNA-mediated expression of human lysosomal α-galactosidase A.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/06//6/1/87
VL  - 165
IS  - 2
M3  - Article
SP  - 275
EP  - 280
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Twelve complementary DNA clones for human lysosomal α-galactosidase A were isolated from an OkayamaBerg library constructed from SV40-transformed human fibroblasts. The identity of these clones was confirmed by complete colinearity of the nucleotide-deduced amino acid sequence with that determined by direct chemical sequencing of human placental α-galactosidase A. Hybridization of the α-galactosidase A cDNA to genomic DNA from individuals with varying numbers of X chromosomes as well as from interspecies somatic-cell hybrids showed only a single locus in the genome at Xq 13.1-Xq 22. One eDNA clone (pcD-AG210) contained the complete coding sequence for both the signal peptide and mature α-galactosidase A. The signal peptide of 31 amino acids contains the expected hydrophobic domains consisting of Leu-Gly-Cys-Ala-Leu-Ala-Leu and PheLeu-Ala-Leu-Val and has Ala at the signal peptidase cleavage site. Twelve out of fifteen G residues flanking the 5' end of the cDNA in pcD-AG210 were removed and the truncated fragment was ligated into the original vector. This construct, pcD-AG502, encoded enzymatically active human α-galactosidase A in monkey COS cells. [ABSTRACT FROM AUTHOR]
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KW  - LYSOSOMES
KW  - GALACTOSE
KW  - DNA
KW  - AMINO acids
KW  - GENOMES
KW  - GENETICS
N1  - Accession Number: 13726966; Tsuji, Shoji 1 Martin, Brian M. 1 Kaslow, David C. 2 Migeon, Barbara R. 2 Choudary, Prabhakara V. 3 Stubbleflied, Barbara K. 1 Mayor, June A. 1 Murray, Gary J. 4 Barranger, John A. 5 Ginns, Edward I. 1; Affiliation:  1: Molecular Neurogenetics Unit, Clinical Neuroscience Branch, National Institute of Mental Health, Alcohol, Drug Abuse and Mental Health Administration, Bethesda, Maryland  2: Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland  3: Centers for Biotechnology and for Advanced Research in Molecular Genetics, Jawaharlal Nehru University, New Delhi  4: Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders, and Stroke, National Institutes of Health, Bethesda, Maryland  5: Division of Medical Genetics, Children's Hospital of Los Angeles, California; Source Info: 6/1/87, Vol. 165 Issue 2, p275; Subject Term: LYSOSOMES; Subject Term: GALACTOSE; Subject Term: DNA; Subject Term: AMINO acids; Subject Term: GENOMES; Subject Term: GENETICS; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Lakatta, Edward G.
T1  - Why cardiovascular function may decline with age.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1987/06//
VL  - 42
IS  - 6
M3  - Article
SP  - 84
EP  - 93
SN  - 0016867X
N1  - Accession Number: 15865245; Lakatta, Edward G. 1,2,3; Source Information: Jun1987, Vol. 42 Issue 6, p84; Number of Pages: 8p; Illustrations: 1 Color Photograph, 1 Diagram, 10 Graphs; Document Type: Article; Full Text Word Count: 2680
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DB  - hch
ER  - 

TY  - JOUR
AU  - Dezubroski, Theodore M.
AU  - Costa Jr., Paul T.
T1  - Coronary Prone Behavior: Components of the Type A Pattern and Hostility.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1987/06//
VL  - 55
IS  - 2
M3  - Article
SP  - 211
EP  - 235
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Traditional and nontraditional risk factors for coronary heart disease (CHD) are discussed with special attention devoted to the Type. A behavior pattern (TABP) Positive and negative epidemiological evidence bearing on the risk factor status of global TABP is reviewed Results of the review suggest that component scoring of the multidimensional global TABP in attempts to uncover "toxic" components, particularly Potential for Hostility, is a profitable research strategy. Similarly, evidence is presented that suggests merit in component scoring of hostility, also a multidimensional construct. To explicate more fully the nature of Potential for Hostility and its categories, correlations between the SI- derived ratings and ratings of established dimensions of individual differences based on the five-factor taxonomic model of personality from subsamples of the MRFIT and WCGS studies are presented. Total Potential for Hostility and especially the Style of interaction category show highly significant relations to Low Agreeableness or Antagonism High ratings of Potential for Hostility identify individuals who can be described as uncooperative, antagonistic, rude, disagreeable, unsympathetic, callous, and the like Implications of the evolving concept of coronary-prone behavior, as distinguished from TABP, are briefly considered [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEART diseases -- Risk factors
KW  - HEART diseases
KW  - CORONARY heart disease
KW  - TYPE A behavior
KW  - HUMAN behavior
KW  - INDIVIDUAL differences
KW  - DIFFERENTIAL psychology
N1  - Accession Number: 8970718; Dezubroski, Theodore M. 1 Costa Jr., Paul T. 2; Affiliation:  1: Department of Psychology, University of Maryland, Baltimore County.  2: Gerontology Research Center, National Institute on Aging, National Institutes of Health.; Source Info: Jun87, Vol. 55 Issue 2, p211; Subject Term: HEART diseases -- Risk factors; Subject Term: HEART diseases; Subject Term: CORONARY heart disease; Subject Term: TYPE A behavior; Subject Term: HUMAN behavior; Subject Term: INDIVIDUAL differences; Subject Term: DIFFERENTIAL psychology; Number of Pages: 25p; Document Type: Article
L3  - 10.1111/1467-6494.ep8970718
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costa Jr., Paul T.
AU  - McCrae, Robert R.
T1  - Neuroticism, Somatic Complaints, and Disease: Is the Bark Worse than the Bite?
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1987/06//
VL  - 55
IS  - 2
M3  - Article
SP  - 299
EP  - 316
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Perhaps because negative emotions are frequently expressed in physiological reactions, psychosomatic theories have often identified Neuroticism and its component traits (including anxiety, anger, and depression) as causal influences on the development of disease These views are apparently supported by correlations between physical symptom reports and measures of Neuroticism in males Data from 347 adult women in the Baltimore Longitudinal Study of Aging replicate this finding for total physical complaints and for most body systems However, analyses of mortality in the literature and in the present article show no influence of Neuroticism, suggesting that symptom re- porting may be biased by Neuroticism-related styles of perceiving and reporting physiological experiences Researchers in this area are urged to employ objective measures of medical status, and to be alert to possible biases of self-selection and selective perception in interpreting associations between Neuroticism and disease [ABSTRACT FROM AUTHOR]
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KW  - PSYCHOSOMATIC medicine -- Research
KW  - STRESS (Psychology)
KW  - WOMEN -- Health
KW  - NEUROSES
KW  - LONGITUDINAL method
KW  - CORRELATION (Statistics)
N1  - Accession Number: 8970749; Costa Jr., Paul T. 1 McCrae, Robert R. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Jun87, Vol. 55 Issue 2, p299; Subject Term: PSYCHOSOMATIC medicine -- Research; Subject Term: STRESS (Psychology); Subject Term: WOMEN -- Health; Subject Term: NEUROSES; Subject Term: LONGITUDINAL method; Subject Term: CORRELATION (Statistics); Number of Pages: 18p; Document Type: Article
L3  - 10.1111/1467-6494.ep8970749
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - WALLIKER, DAVID
AU  - QUAKYI, ISABELLA A.
AU  - WELLEMS, THOMAS E.
AU  - MCCUTCHAN, THOMAS F.
AU  - SZARFMAN, ANA
AU  - LONDON, WILLIAM T.
AU  - CORCORAN, LYNN M.
AU  - BURKOT, THOMAS R.
AU  - CARTER, RICHARD
T1  - Genetic Analysis of the Human Malaria Parasite Plasmodium falciparum.
JO  - Science
JF  - Science
Y1  - 1987/06/26/
VL  - 236
IS  - 4809
M3  - Article
SP  - 1661
EP  - 1666
SN  - 00368075
AB  - Malaria parasites are haploid for most of their life cycle, with zygote formation and meiosis occurring during the mosquito phase of development. The parasites can be analyzed genetically by transmiting mixtures of cloned parasites through mosquitoes to permit cross-fertilization of gametes to occur. A cross was made between two clones of Plasmodiumfakciparum differing in enzymes, drug sensitivity, antigens, and chromosome patterns. Parasites showing recombination between the parent clone markers were detected at a high frequency. Novel forms of certain chromosomes, detected by pulsed-field gradient gel electrophoresis, were produced readily, showing that extensive rearrangements occur in the parasite genome after cross-ferdlization. Since patients are frequently infected with mixtures ofgenetically distinct parasites, mosquito transmission is likely to provide the principal mechanisms for generating parasites with novel genotypes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436755; WALLIKER, DAVID 1 QUAKYI, ISABELLA A. 1 WELLEMS, THOMAS E. 1 MCCUTCHAN, THOMAS F. 1 SZARFMAN, ANA 2 LONDON, WILLIAM T. 3 CORCORAN, LYNN M. 4 BURKOT, THOMAS R. 5 CARTER, RICHARD 1,6; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Heafth, Bethesda, MD 20892  2: Naval Medical Research Institute and Uniformed Services Universitv of Health Sciences, Bethesda, MD 20814  3: National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892  4: Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia  5: Papua New Guinea Institute of Medical Research, Post Office Box 378, Madang, Papua New Guinea  6: Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 31N, Scotland.; Source Info: 6/26/1987, Vol. 236 Issue 4809, p1661; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Campos, Florisbela A. C. S.
AU  - Flores, Hemando
AU  - Underwood, Barbara A.
T1  - Effect of an infection on vitamin A status of children as measured by the relative dose response (RDR).
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/07//
VL  - 46
IS  - 1
M3  - Article
SP  - 91
EP  - 94
SN  - 00029165
AB  - The effect of an infective episode of chickenpox on the vitamin A status of preschool-aged children was evaluated by use of the relative dose response (RDR) test. Status was determined before and 30, 120, and 180 d after administration of a single oral high-dosage (200 000 IU) supplement of vitamin A. No differences in mean blood levels of retinol or percentage of children showing a positive RDR were apparent until after the infective episode that occurred ~90 d after dosing. At 180 d postsupplementation, 74% of children who had been infected tested positive by the RDR, indicative of an inadequate liver reserve of vitamin A, in contrast to only 10% who had not been infected. Paired RDR observations at 0 and 180 d postsupplementation confirmed that the infective episode caused an accelerated depletion of liver reserves of vitamin A. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Infection
KW  - Chickenpox
KW  - Vitamin A in human nutrition
KW  - Vitamin A deficiency
KW  - Gastroenteritis
KW  - Liver
KW  - infection
KW  - relative dose response
KW  - Vitamin A status
N1  - Accession Number: 91731561; Campos, Florisbela A. C. S. 1; Flores, Hemando 1; Underwood, Barbara A. 2; Affiliations: 1: Laboratory of Nutritional Biochemistry, Department of Nutrition, Federal University of Pernambuco, Brazil; 2: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Jul1987, Vol. 46 Issue 1, p91; Thesaurus Term: Infection; Subject Term: Chickenpox; Subject Term: Vitamin A in human nutrition; Subject Term: Vitamin A deficiency; Subject Term: Gastroenteritis; Subject Term: Liver; Author-Supplied Keyword: infection; Author-Supplied Keyword: relative dose response; Author-Supplied Keyword: Vitamin A status; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Uphoff, Delta E.
T1  - Fetal and maternal tissues.
JO  - American Scientist
JF  - American Scientist
Y1  - 1987/07//Jul/Aug87
VL  - 75
IS  - 4
M3  - Letter
SP  - 346
EP  - 346
SN  - 00030996
AB  - Presents a letter to the editor commenting on John C. Rodger and Belinda L. Drake's article entitled 'The Enigma of the Fetal Graft.'
KW  - Fetal tissue transplants
KW  - Letters to the editor
N1  - Accession Number: 11232774; Uphoff, Delta E. 1; Affiliations: 1: National Cancer Institute, Bethesda, MD; Issue Info: Jul/Aug87, Vol. 75 Issue 4, p346; Subject Term: Fetal tissue transplants; Subject Term: Letters to the editor; Number of Pages: 1/4p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Westerhoff, Hans V.
T1  - In Search of the Physical Basis of Life (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1987/07//Jul/Aug87
VL  - 75
IS  - 4
M3  - Book Review
SP  - 432
EP  - 432
SN  - 00030996
AB  - Reviews the book 'In Search of the Physical Basis of Life,' by Gilbert N. Ling.
KW  - Biology
KW  - Nonfiction
KW  - Ling, Gilbert N.
KW  - In Search of the Physical Basis of Life (Book)
N1  - Accession Number: 11232814; Westerhoff, Hans V. 1; Affiliations: 1: National Institutes of Health; Issue Info: Jul/Aug87, Vol. 75 Issue 4, p432; Thesaurus Term: Biology; Subject Term: Nonfiction; Reviews & Products: In Search of the Physical Basis of Life (Book); People: Ling, Gilbert N.; Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Tung, K. S. K.
AU  - Umland, Edith
AU  - Matzner, P.
AU  - Nelson, K.
AU  - Schauf, Victoria
AU  - Rubin, L.
AU  - Wagner, D.
AU  - Scollard, D.
AU  - Vithayasai, Prakong
AU  - Vithayasai, Vicharn
AU  - Worobec, Sophie
AU  - Smith, T.
AU  - Vinai Suriyanond
T1  - Soluble serum interleukin 2 receptor levels in leprosy patients.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/07//
VL  - 69
IS  - 1
M3  - Article
SP  - 10
EP  - 15
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Soluble interleukin 2 receptors (IL-2R) in sera of leprosy patients from Chiang Mai, Thailand, were quantified with a solid phase enzyme immunoassay using two monoclonal antibodies to the IL-2R. The IL-2R levels of untreated lepromatous, borderline lepromatous or midborderline patients and treated lepromatous and borderline lepromatous or treated borderline tuberculoid and tuberculoid patients were comparable to those of the Thai household or nonhousehold contacts: and they were significantly higher than the levels of USA control subjects. In contrast. IL-2R of untreated tuberculoid or borderline tuberculoid patients were significantly reduced. Patients with ongoing reversal reaction had very high circulating IL-2R. the levels of which correlated with lever and extent of skin lesions. Although erythrema nodosum leprosum patients also had elevated IL-2R levels. they were significantly below those of patients with reversal reaction. When treated with corticosteroid. precipitous reduction of IL-2R was noted in all patients with reversal reaction but not in patients with erythema nodosum leprosum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - SERUM
KW  - BLOOD plasma
KW  - MYCOBACTERIAL diseases
KW  - MONOCLONAL antibodies
KW  - INTERLEUKIN-2
KW  - interleukin 2 receptor.
KW  - leprosy
KW  - reversal reaction
N1  - Accession Number: 16183391; Tung, K. S. K. 1 Umland, Edith 1 Matzner, P. 1 Nelson, K. 2 Schauf, Victoria 2 Rubin, L. 3 Wagner, D. 3 Scollard, D. 4 Vithayasai, Prakong 4 Vithayasai, Vicharn 4 Worobec, Sophie 4 Smith, T. 4 Vinai Suriyanond 4; Affiliation:  1: Department of Pathology, University of New Mexico School of Medicine, Albuquerque.  2: Department of Preventive Medicine, University of Illinois, Chicago.  3: Immunology Section, Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda.  4: Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Source Info: Jul1987, Vol. 69 Issue 1, p10; Subject Term: IMMUNOGLOBULINS; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: MYCOBACTERIAL diseases; Subject Term: MONOCLONAL antibodies; Subject Term: INTERLEUKIN-2; Author-Supplied Keyword: interleukin 2 receptor.; Author-Supplied Keyword: leprosy; Author-Supplied Keyword: reversal reaction; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ansel, John C.
AU  - Luger, Thomas A.
AU  - Green, Ira
T1  - Fever and Increased Serum IL-1 Activity As a Systemic Manifestation of Acute Phototoxicity in New Zealand White Rabbits.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/07//
VL  - 89
IS  - 1
M3  - Article
SP  - 32
EP  - 37
SN  - 0022202X
AB  - Ultraviolet (UV) radiation is a significant environmental hazard for humans and animals. Although the clinical effect of an acute UV exposure such as cutaneous inflammation, malaise, somnolence, chills, and fever have been appreciated for many years, the underlying mechanisms mediating these effects are poorly understood. Since chills and fever are the most dramatic systemic sequelae after a prolonged exposure to UV, we specifically examined the effect of whole-body UV irradiation on core body temperature and serum endogenous pyrogen activity of New Zealand White rabbits, correlating this with serum interleukin I (IL-1) activity and alterations of serum divalent cation levels. We found that an acute dose of UV irradiation (Westinghouse FS-40 lamps, 0.2 mJ/cm2/s × 8 h) resulted in a significant increase in the core body temperature 2 h post UV (0.8°C), peaking 5 h post UV (1.8°C), and returning to normal 24 h post UV. Likewise, the sera from the UV-irradiated rabbits had significant endogenous pyrogen activity when transferred into naive recipient animals, causing an increase in core body temperature within 45 min (0.65 ± 0.12°C), decreasing over the next 2 h, and returning to normal 6 h post injection. No endotoxin contamination was detected in any serum samples. This post-UV febrile response was accompanied by a prolonged increase in serum IL-1 activity (5-10 X ) and a significant alteration in serum divalent cation levels, with the rabbits becoming euthermic even as the serum IL-I levels remained elevated. These findings provide new information concerning the pathogenesis and kinetics of these systemic effects after an acute dose of UV irradiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SERUM
KW  - INTERLEUKIN-1
KW  - ULTRAVIOLET radiation
KW  - SKIN -- Inflammation
KW  - ENDOTOXINS
KW  - BODY temperature
N1  - Accession Number: 12580362; Ansel, John C. 1 Luger, Thomas A. 2 Green, Ira 3; Affiliation:  1: Departments of Dermatology, Veterans Administration Medical Center and The Oregon Health Sciences University, Portland, Oregon, U.S.A.  2: Department of Dermatology, Ludvig Bolstsmnan Institute for Dermatovenerological Serodiagnosis, Laboratory for Cell Biology, University of Vienna, Vienna, Austria.  3: Laboratory of Immunology, National Institute of Allergy amid Infectious Diseases, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p32; Subject Term: SERUM; Subject Term: INTERLEUKIN-1; Subject Term: ULTRAVIOLET radiation; Subject Term: SKIN -- Inflammation; Subject Term: ENDOTOXINS; Subject Term: BODY temperature; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12580362
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nagae, Shonosuke
AU  - Lichti, Ulrike
AU  - De Luca, Luigi M.
AU  - Yuspa, Stuart H.
T1  - Effect of Retinoic Acid on Cornified Envelope Formation: Difference Between Spontaneous Envelope Formation In Vivo or In Vitro and Expression of Envelope Competence.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/07//
VL  - 89
IS  - 1
M3  - Article
SP  - 51
EP  - 58
SN  - 0022202X
AB  - A large number of cross-linked envelopes form spontaneously when cell lines derived from chemically induced mouse skin papillomas are cultured in medium containing 1.2 mM calcium. This phenomenon is associated with high activity of the cross-linking enzyme, epidermal transglutamjnase (TGase). The influence of retinoic acid (RA) on envelope formation was studied in detail in a papilloma cell line, PE. Retinoic acid (3 μM) completely blocked cornified envelope (CE) production but reduced TGase activity only 50%. A rabbit antiserum was produced against sonicated CEs isolated from newborn mouse skin. On Western blots of epidermal extracts, diffuse staining was observed for particulate proteins of suprabasal, but not basal, cells and similar immunoreactive material was absent from the cytosolic fraction of both cell layers. The antibody also recognized particulate proteins from PE cells induced to differentiate by calcium, but not from cells grown in the presence of high calcium and RA. The antiserum appears to recognize partially cross-linked CE precursor proteins judging by the diffuse staining, the molecular weight range of the proteins stained, and their origin in the particulate cellular fraction. Cross-linked envelopes could be induced in RA-treated PE cells by permeabilization with 0.75 M NaCI or 50 μg/ml A23187. However, this treatment failed to cause the appearance of proteins recognized by the antiserum. Preincubation of the antiserum with purified fragments of CEs from newborn mouse epidermis, but not with cross-linked envelopes from permeabilized, RA-treated PE cells, removed immunoreactivity. These results indicate that the cross-linked envelopes formed in RA-treated cells after permeabilization lack a set of proteins contained in CEs from stratum corneum and may even be composed of different proteins. Retinoic acid appears to prevent CE formation in part by inhibiting activation of epidermal TGase but in addition by influencing the synthesis of precursor proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRETINOIN
KW  - CALCIUM
KW  - TRANSGLUTAMINASES
KW  - SERUM
KW  - EPIDERMIS
KW  - PROTEIN precursors
N1  - Accession Number: 12580383; Nagae, Shonosuke 1 Lichti, Ulrike 1 De Luca, Luigi M. 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p51; Subject Term: TRETINOIN; Subject Term: CALCIUM; Subject Term: TRANSGLUTAMINASES; Subject Term: SERUM; Subject Term: EPIDERMIS; Subject Term: PROTEIN precursors; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12580383
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Falanga, Vincent
AU  - Tiegs, Susan L.
AU  - Alstadt, Stephanie P.
AU  - Roberts, Anita B.
AU  - Sporn, Michael B.
T1  - Transforming Growth Factor-Beta: Selective Increase in Glycosaminoglycan Synthesis by Cultures of Fibroblasts From Patients With Progressive Systemic Sclerosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/07//
VL  - 89
IS  - 1
M3  - Article
SP  - 100
EP  - 104
SN  - 0022202X
AB  - Transforming growth factor-beta (TGF-beta) has been found in all cells examined thus far, and has been shown to play an important role in inflammation and connective tissue formation. We now report that TGF-beta, alone or in combination with epidermal growth factor (EGF), led to a preferential increase in glycosaminoglycan synthesis by cultures of dermal fibroblasts from patients with progressive systemic sclerosis (PSS) when compared with normal fibroblasts (<em>p</em> < 0.001). Transforming growth factor-beta increased collagen synthesis to the same extent in both PSS and normal fibroblasts, whereas EGF had no stimulatory activity on collagen synthesis. The addition of EGE to cultures incubated with TGF-beta led to a decrease in collagen synthesis compared with the effect seen with TGF-beta alone (<em>p</em> <0.02). These studies suggest that TGF-beta may play an important role in the accumulation of connective tissue seen in PSS and that the combined action of multiple growth factors may modulate the synthetic activity of human dermal fibroblasts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GROWTH factors
KW  - CYTOKINES
KW  - GLYCOSAMINOGLYCANS
KW  - FIBROBLASTS
KW  - SYSTEMIC scleroderma
KW  - MUCOPOLYSACCHARIDES
N1  - Accession Number: 12580445; Falanga, Vincent 1 Tiegs, Susan L. 1 Alstadt, Stephanie P. 1 Roberts, Anita B. 2 Sporn, Michael B. 2; Affiliation:  1: Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.  2: National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p100; Subject Term: GROWTH factors; Subject Term: CYTOKINES; Subject Term: GLYCOSAMINOGLYCANS; Subject Term: FIBROBLASTS; Subject Term: SYSTEMIC scleroderma; Subject Term: MUCOPOLYSACCHARIDES; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12580445
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raynaud, Françoise
AU  - Leduc, Claire
AU  - Anderson, Wayne B.
AU  - Evain-Brion, Danièle
T1  - Retinoid Treatment of Human Psoriatic Fibroblasts Induces an Increase in Cyclic AMP-Dependent Protein Kinase Activity.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/07//
VL  - 89
IS  - 1
M3  - Article
SP  - 105
EP  - 110
SN  - 0022202X
AB  - We recently showed a deficiency of cyclic AMP (cAMP)- dependent protein kinases in psoriatic cells. In this work the effects of retinoids on cAMP-dependent protein kinases of fibroblasts from 7 normal subjects and 7 psoriatic patients were studied. The levels of RI and RII (two forms of the cAMP-dependent protein kinases) present in control and retinoic acid-treated cells were quantitated by photoaffinity labeling with [8-azido-32P]cAMP. In psoriatic fibroblasts the levels of Rh are decreased or undetectable compared with those of normal fibroblasts both in the cytosolic and membrane fractions. The amount of RI was normal in the cytosol of fibroblasts of 5 out of 7 patients and decreased in 2 patients. Membrane-associated levels of RI were decreased in 5 patients and normal in 2 patients. Retinoic acid treatment induces an increase in the amount of RI and RII regulatory subunits when they are deficient in the cytosolic and membrane fractions of psoriatic fibroblasts. Retinoic acid had no effect on RI and Rh in normal fibroblasts. In addition, with in vitro retinoic acid treatment the cAMP-dependent protein kinase activity, measured in the fibroblasts of 4 psoriatic patients, was increased in the cytosol in 2 patients and in the membranes in all 4 patients. In these studies, comparable results were obtained with fibroblasts cultured from involved and uninvolved skin. This in vitro effect of retinoids on cAMP-dependent protein kinases in psoriatic fibroblasts may help to explain some of the in vivo therapeutic effects of retinoids. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RETINOIDS
KW  - FIBROBLASTS
KW  - CONNECTIVE tissue cells
KW  - PROTEIN kinases
KW  - PHOSPHOTRANSFERASES
KW  - DITERPENES
N1  - Accession Number: 12580448; Raynaud, Françoise 1 Leduc, Claire 1 Anderson, Wayne B. 2 Evain-Brion, Danièle 1; Affiliation:  1: Unite INSERM 188, Paris, France,  2: Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p105; Subject Term: RETINOIDS; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; Subject Term: PROTEIN kinases; Subject Term: PHOSPHOTRANSFERASES; Subject Term: DITERPENES; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12580448
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06450-047
AN  - 2006-06450-047
AU  - Ingraham, Loring J.
T1  - A Medical Approach to Psychodiagnosis.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/07//
VL  - 32
IS  - 7
SP  - 659
EP  - 660
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06450-047. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Ingraham, Loring J.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychiatry; Psychodiagnosis; Testing. Minor Descriptor: Mental Disorders. Classification: Clinical Psychological Testing (2224); Psychological & Physical Disorders (3200). Population: Human (10). Reviewed Item: Gold, Mark S. (Ed); Pottash, A. L. C. (Ed). Diagnostic and Laboratory Testing in Psychiatry=New York: Plenum Press, 1986. 299 pp. 32.50; 1986. Page Count: 2. Issue Publication Date: Jul, 1987. 
AB  - Reviews the book, Diagnostic and Laboratory Testing in Psychiatry edited by Mark S. Gold and A. L. C. Pottash (1986). The editors of this book take aim at the diagnostic practices of their psychiatric colleagues and find them wanting. The editors propose that the appropriate use of newer laboratory tests can successfully separate psychiatric illness from other medical illnesses and that the results of laboratory testing can be used to specify appropriate treatment. The chapters are successful in cogently explicating a variety of physical illnesses masquerading as psychiatric illness. The contributors optimistically present a number of laboratory tests with the potential to both differentiate psychiatric illness from identifiable organic illnesses and identify treatment (psychopharmacological) responders. This volume may thus be useful to both clinicians and investigators, it can educate clinicians in how to request appropriate medical consultation in their practice and can suggest to investigators avenues for collaborative approaches to psychodiagnosis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric illness
KW  - laboratory tests
KW  - laboratory testing
KW  - medical illnesses
KW  - psychiatry
KW  - psychodiagnosis
KW  - 1987
KW  - Psychiatry
KW  - Psychodiagnosis
KW  - Testing
KW  - Mental Disorders
KW  - 1987
U2  - Gold, Mark S. (Ed); Pottash, A. L. C. (Ed). (1986); Diagnostic and Laboratory Testing in Psychiatry; New York: Plenum Press, 1986. 299 pp. 32.50; 0-306-42054-6.
DO  - 10.1037/027333
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Corda, Daniela
AU  - Sekura, Ronald D.
AU  - Kohn, Leonard D.
T1  - Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/07/15/
VL  - 166
IS  - 2
M3  - Article
SP  - 475
EP  - 481
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Incubation of FRTL-5 rat thyroid cell membranes with [32P]NAD and pertussis toxin results in the specific ADP-ribosylation of a protein of about 40 kDa. This protein has the same molecular mass of the αi subunit of the adenylate cyclase regulatory protein Ni and is distinct from proteins ADP-ribosylated by cholera toxin in the same membranes. Prior treatment of FRTL-5 cells with pertussis toxin results in the ADP-ribosylation of Ni, as indicated by the loss of the toxin substrate in the ADP-ribosylation assay performed with membranes prepared from such cells. Preincubation of FRTL-5 cells with thyrotropin causes the same loss; cholera toxin has no such effect. Pertussis toxin, as do thyrotropin and cholera toxin, increases cAMP levels in FRTL-5 cells. Forskolin together with thyrotropin, cholera toxin or pertussis toxin causes a further increase in cAMP levels. Petussis toxin and thyrotropin are not additive in their ability to increase adenylate cyclase activity, whereas both substances are additive with cholera toxin. A role of Ni in the thyrotropin regulation of the adenylate cyclase activity in thyroid cells is proposed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYROTROPIN
KW  - GLYCOPROTEIN hormones
KW  - PITUITARY hormones
KW  - ADENOSINE diphosphate
KW  - PERTUSSIS toxin
KW  - BACTERIAL toxins
N1  - Accession Number: 13801311; Corda, Daniela 1,2 Sekura, Ronald D. 3 Kohn, Leonard D. 1; Affiliation:  1: Section on Cell Regulation, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland  2: Istituto di Ricerche Farmacologiche 'Mario Negri', Milano, Italy  3: Laboratory of Development and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 7/15/87, Vol. 166 Issue 2, p475; Subject Term: THYROTROPIN; Subject Term: GLYCOPROTEIN hormones; Subject Term: PITUITARY hormones; Subject Term: ADENOSINE diphosphate; Subject Term: PERTUSSIS toxin; Subject Term: BACTERIAL toxins; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ARRIZA, JEFFREY L.
AU  - WEINBERGER, CARY
AU  - CERELLI, GAIL
AU  - GLASER, TOM M.
AU  - HANDELIN, BARBARA L.
AU  - HOUSMAN, DAVID E.
AU  - EVANS, RONALD M.
T1  - Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor.
JO  - Science
JF  - Science
Y1  - 1987/07/17/
VL  - 237
IS  - 4812
M3  - Article
SP  - 268
EP  - 275
SN  - 00368075
AB  - Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide. Expression studies demonstrate its ability to bind aldosterone with high affinity and to activate gene transcription in response to aldosterone, thus establishing its identity as the human mineralocorticoid receptor (hMR). This molecule also shows high affinity for glucocorticoids and stimulates a glucocorticoid-responsive promoter. Together the hMR and hGR provide unexpected functional diversity in which hormone-binding properties, target gene interactions, and patterns of tissue-specific expression may be used in a combinatorial fashion to achieve complex physiologic control. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87436224; ARRIZA, JEFFREY L. 1,2 WEINBERGER, CARY 3,4 CERELLI, GAIL 3 GLASER, TOM M. 5 HANDELIN, BARBARA L. 5 HOUSMAN, DAVID E. 5 EVANS, RONALD M. 3; Affiliation:  1: University of California at San Diego, Department of Biology, LaJolla, CA 92093  2: Gcne Expression Laboratory, The Salk Institute for Biofogical Studies, P.O. Box 85800, San Diego CA 92138  3: Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, P.O. Box 85800, San Diego, CA 92138  4: National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892  5: Massachusetts Institute of Technology, Center for Cancer Research, Cambridge, MA 02139; Source Info: 7/17/1987, Vol. 237 Issue 4812, p268; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Micozzi, Marc S.
AU  - Albanes, Demetrius
AU  - Garn, Stanley M.
AU  - Leonard, William R.
AU  - Hawthorne, Victor
T1  - Three limitations of the body mass index.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/08//
VL  - 46
IS  - 2
M3  - Article
SP  - 376
EP  - 377
SN  - 00029165
AB  - A letter to the editor is presented in response to the article related to the limitation of the body mass index in the anthropometry.
KW  - Body mass index
KW  - Anthropometry
N1  - Accession Number: 91655096; Micozzi, Marc S. 1; Albanes, Demetrius 2; Garn, Stanley M. 3; Leonard, William R. 3; Hawthorne, Victor 3; Affiliations: 1: Armed Forces Institutes of Pathology Washington, DC 30306-6000; 2: Cancer Prevention Studies Branch, National Cancer Institute, Blair Bldg, Rm 6A-09, Bethesda, MD 20892-4200; 3: Center for Human Growth, University of Michigan, Nutrition Unit, School of Public Health and Department of Epidemiology, Ann Arbor, MI 48109; Issue Info: Aug1987, Vol. 46 Issue 2, p376; Subject Term: Body mass index; Subject Term: Anthropometry; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ranki, Annamari
AU  - Weiss, S. H.
AU  - Valle, Sirkka-Liisa
AU  - Antonen, J.
AU  - Krohn, K. J.
T1  - Neutralizing antibodies in HIV (HTLV-III) infection: correlation with clinical outcome and antibody response against different viral proteins.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/08//
VL  - 69
IS  - 2
M3  - Article
SP  - 231
EP  - 239
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Sequential serum samples, collected over a 2- 3 year follow-up period, of 28 HIV-infected individuals were tested for the presence of neutralizing antibodies against one HIV isolate, HTLV-IIIB. and titrated, by Western blotting, against different HTLV-III specific proteins. Neutralizing antibodies were found in 66% of the samples tested and highest neutralization titres observed in cases with lymphadenopathy syndrome. Antibody titres against the viral proteins also seemed to be highest in cases with LAS. Neutralization titres correlated well with antibodies to envelope glycoproteins gp4l and gpl20 and to one of the core proteins. pl7. An increase in neutralization titre during the follow-up period was associated with a stable clinical course. Furthermore, the occurrence of antibodies directed against the external envelope glycoprotein (gpl20) in the initial scrum sample correlated well with a stable clinical course. The results suggest that neutralizing activity in the scrum, particularly that evoked against gpl20. may have some prognostic significance. and that several distinct antigenic epitopes on the virus may be a target for neutralizing antibodies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SERUM
KW  - BLOOD plasma
KW  - MICROBIAL proteins
KW  - ANTIGENIC determinants
KW  - VIRUSES
KW  - AIDS (Disease)
KW  - HTLV-III infection neutralizing antibodies gp120
N1  - Accession Number: 16141784; Ranki, Annamari 1,2 Weiss, S. H. 3 Valle, Sirkka-Liisa 2 Antonen, J. 4 Krohn, K. J. 1,4; Affiliation:  1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesa, Maryalnd.  2: Department of Dermatology, University of Helsinki, Helsinki, Finland.  3: Environmental Epidemiology Branch, National Cancer Institute, Bethesa, Maryland, USA.  4: Institute of Biomedical Sciences, University of Tampere, Tampere, Finland.; Source Info: Aug1987, Vol. 69 Issue 2, p231; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: MICROBIAL proteins; Subject Term: ANTIGENIC determinants; Subject Term: VIRUSES; Subject Term: AIDS (Disease); Author-Supplied Keyword: HTLV-III infection neutralizing antibodies gp120; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chopra, R. K.
AU  - Nagel, J. E.
AU  - Chrest, F. J.
AU  - Boto, W. M.
AU  - Pyle, R. S.
AU  - Dorsey, Barbara
AU  - McCoy, M.
AU  - Holbrook, Nikki
AU  - Adler, W. H.
T1  - Regulation of interleukin 2 and interleukin 2 receptor gene expression in human T cells: 1. effect of Ca22+ -- ionophore on phorbol myristate acetate co-stimulated cells.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/08//
VL  - 69
IS  - 2
M3  - Article
SP  - 433
EP  - 440
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Human peripheral blood T lymphocytes were treated with phorbol myristate acetate (PMA), an activator of protein kinase C (PKC) activity, and with the calcium ionophore A23187. The resulting accumulation of specific mRNA for interleukin 2 (IL-2) and interleukin 2 receptor (IL-2R), as well as IL-2 secretion and membrane IL-2R expression were examined. At low concentrations (0.1 μM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion. A high concentration of A23187 (1.0 μM) did not show any synergism for the accumulation of IL-2R mRNA, membrane IL-2R expression and inhibited the proliferation of PMA co-stimulated T cells. It did, however, induce maximum accumulation of IL-2 mRNA and IL-2 secretion. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MESSENGER RNA
KW  - T cells
KW  - GENE expression
KW  - GENETIC regulation
KW  - PROTEIN kinases
KW  - PROTEIN kinase C
KW  - Ca ionophore phorbol myristate acetate lymphocytes interleukin 2
N1  - Accession Number: 16142246; Chopra, R. K. 1 Nagel, J. E. 1 Chrest, F. J. 1 Boto, W. M. 1 Pyle, R. S. 1 Dorsey, Barbara 1 McCoy, M. 2 Holbrook, Nikki 2 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology research Center, National Institute on Aging, National Institute of Health, Baltimore, Maryland.  2: Laboratory of Molecular Genetics, Gerontology research Center, National Institute on Aging, National Institute of Health, Baltimore, Maryland.; Source Info: Aug1987, Vol. 69 Issue 2, p433; Subject Term: MESSENGER RNA; Subject Term: T cells; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: PROTEIN kinases; Subject Term: PROTEIN kinase C; Author-Supplied Keyword: Ca ionophore phorbol myristate acetate lymphocytes interleukin 2; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wolfe, Mary D.
AU  - Carlos, James P.
T1  - Oral health effects of smokeless tobacco use in Navajo Indian adolescents.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1987/08//
VL  - 15
IS  - 4
M3  - Article
SP  - 230
EP  - 235
SN  - 03015661
AB  - Recent reports have suggested that the use of smokeless tobacco is increasing in adolescents, and is particularly high in Native Americans, causing concern about possible effects on oral health. In this study, 226 Navajo Indians, aged 14-19, were interviewed regarding their use of smokeless tobacco (ST), cigarettes, and alcohol, Midbuccal and mesiobuccal sites on all fully erupted permanent teeth (excluding third molars) were examined for the presence of gingival bleeding, gingival recession, calculus, and loss of periodontal attachment. The oral mucosa was examined for evidence of leukoplakia. 64.2% (145) of the subjects (75.4% of the boys and 49.0% of the girls) were users of ST. Of these, over 95% used snuff alone or in combination with chewing tobacco. 55.9% used ST one or more days per week. 52.2% consumed alcohol, usually beer or wine, and 54.0% smoked cigarettes. 25.5% (37) of the users and 3.7% (3) of the non-users had leukoplakia. The duration (in years) and frequency of ST use (days per week) were highly significant risk factors associated with leukoplakia. However, the concomitant use of alcohol or cigarettes did not appear to increase the prevalence of these lesions. No consistent relationship was observed between the use of ST and gingival bleeding, calculus, gingival recession, or attachment loss, either when comparing users to non-users or when comparing the segment where the tobacco quid was habitually placed to a within-subject control segment. In view of these results, there is little doubt that smokeless tobacco is significantly related to the etiology of leukoplakia. As some evidence exists that smokeless tobacco use is a significant risk factor associated with oral carcinoma, intervention programs to discourage the use of smokeless tobacco by adolescents should be a public health priority. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUTRITION & dental health
KW  - SMOKELESS tobacco
KW  - TEENAGERS
KW  - GUM disease
KW  - ORAL mucosa
KW  - PUBLIC health
KW  - INDIA
KW  - adolescence; Indians
KW  - leukoplakia
KW  - Navajo
KW  - North American
KW  - periodontal diseases
KW  - smokeless tobacco
N1  - Accession Number: 12014464; Wolfe, Mary D. 1 Carlos, James P. 1; Affiliation:  1: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research National Institutes of Health, Bethesda Maryland, USA; Source Info: Aug1987, Vol. 15 Issue 4, p230; Subject Term: NUTRITION & dental health; Subject Term: SMOKELESS tobacco; Subject Term: TEENAGERS; Subject Term: GUM disease; Subject Term: ORAL mucosa; Subject Term: PUBLIC health; Subject Term: INDIA; Author-Supplied Keyword: adolescence; Indians; Author-Supplied Keyword: leukoplakia; Author-Supplied Keyword: Navajo; Author-Supplied Keyword: North American; Author-Supplied Keyword: periodontal diseases; Author-Supplied Keyword: smokeless tobacco; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12014464
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Emonard, Hervé
AU  - Calle, Aleth
AU  - Grimaud, Jean-Alexis
AU  - Peyrol, Simone
AU  - Castronovo, Vincent
AU  - Noel, Agnès
AU  - Lapière, Charles M.
AU  - Kleinman, Hynda K.
AU  - Foidart, Jean-Michel
T1  - Interactions Between Fibroblasts and a Reconstituted Basement Membrane Matrix.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/08//
VL  - 89
IS  - 2
M3  - Article
SP  - 156
EP  - 163
SN  - 0022202X
AB  - A gel-like reconstituted basement membrane matrix containing type IV collagen, laminin, entactin, nidogen, and heparan sulfate proteoglycan was used to examine the interactions between normal calf skin fibroblasts and basement membranes. Within 6 h after seeding, fibroblasts initiated a migration that resulted in the formation of a cellular network after 1 day of culture on top of the gel. Electron microscopy revealed that fibroblasts were able to remodel the basement membrane matrix by penetrating into the gel (from day 3), depositing fibronectin and collagen fibers, and retracting this extracellular matrix. Fibroblasts cultured on the Engelbreth-Holm-Swarm reconstituted basement membrane matrix displayed ultrastructural features characterized by a poor synthetic apparatus (rough endoplasmic reticulum and Golgi vesicles), a large cytoskeleton, and intracytoplasmic vesicles containing laminin. Thus the reconstituted basement membrane matrix is remodeled by skin fibroblasts, and reciprocally their ultrastructural morphologic features are affected by this matrix. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLLAGEN
KW  - EXTRACELLULAR matrix proteins
KW  - PROTEOGLYCANS
KW  - GLYCOPROTEINS
KW  - FIBROBLASTS
KW  - ENDOPLASMIC reticulum
N1  - Accession Number: 12470552; Emonard, Hervé 1 Calle, Aleth 1 Grimaud, Jean-Alexis 2 Peyrol, Simone 2 Castronovo, Vincent 1,3 Noel, Agnès 1 Lapière, Charles M. 1 Kleinman, Hynda K. 4 Foidart, Jean-Michel 1; Affiliation:  1: Laboratory of Experimental Dermatology and Pathophysiology of Pregnancy, University of Liège, Liège, Belgium.  2: Laboratory of Liver Cellular Pathology, C.N.R.S.-UA 602, Institut Pasteur, Lyon, France.  3: Department of Obstetrics and Gynecology, University of Liège, Liège, Belgium.  4: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug87, Vol. 89 Issue 2, p156; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; Subject Term: FIBROBLASTS; Subject Term: ENDOPLASMIC reticulum; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12470552
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hofferth, Sandra L.
AU  - Phillips, Deborah A.
T1  - Child Care in the United States, 1970 to 1995.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1987/08//
VL  - 49
IS  - 3
M3  - Article
SP  - 559
SN  - 00222445
AB  - As the proportion of children with mothers who are working has increased, so has the interest and concern about their care arrangements. This study utilizes trends in the proportion of children with a mother in the labor force along with trends in the number of children to project the proportion of children with employed mothers in 1990 and 1995, by age of child. The authors profile the current distribution of children in non parental care and look at trends over the past two decades. They then present the most recent information on current supply of child care and trends in that supply. Finally, implications of recent developments for the supply of and demand for child care in the future are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD care
KW  - MICROECONOMICS
KW  - PARENT & child
KW  - LABOR supply
KW  - MOTHERS
KW  - UNITED States
N1  - Accession Number: 5274076; Hofferth, Sandra L. 1 Phillips, Deborah A. 2; Affiliation:  1: National Institute of Child Health and Human Development.  2: University of Virginia.; Source Info: Aug87, Vol. 49 Issue 3, p559; Subject Term: CHILD care; Subject Term: MICROECONOMICS; Subject Term: PARENT & child; Subject Term: LABOR supply; Subject Term: MOTHERS; Subject Term: UNITED States; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104761853
T1  - Family morbidity in chronic pain patients.
AU  - Chaturvedi, S K
Y1  - 1987/08//1987 Aug
N1  - Accession Number: 104761853. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Mental Disorders
KW  - Pain
KW  - Adolescence
KW  - Adult
KW  - Chronic Disease
KW  - Family
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Pain -- Psychosocial Factors
SP  - 159
EP  - 168
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 30
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
U2  - PMID: 3670867.
DO  - 10.1016/0304-3959(87)91071-2
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-06451-020
AN  - 2006-06451-020
AU  - Theodore, William H.
T1  - Does the Brain Really have Anything to do with Behavior?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/08//
VL  - 32
IS  - 8
SP  - 720
EP  - 720
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06451-020. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Theodore, William H.; Unit on Cerebral Blood Flow and Metabolism, Medical Neurology Branch, National Institutes of Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Brain; Drug Therapy; Psychopharmacology. Minor Descriptor: Medical Model; Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Trimble, Michael R. (Ed). New Brain Imaging Techniques and Psychopharmacology=Oxford, England: Oxford University Press, 1986. 134 pp. $45.00; 1986. Page Count: 1. Issue Publication Date: Aug, 1987. 
AB  - Reviews the book, New Brain Imaging Techniques and Psychopharmacology edited by Michael R. Trimble (1986). Will the advent of functional images be the next great leap forward for the 'medical model' of psychiatric illness? Trimble and his colleagues attempt to show what has been achieved already. In subsequent chapters, contributors discuss primarily the contribution of PET to the evaluation of patients with psychiatric illness, reviewing the issue of decreased cerebral blood flow and metabolism in schizophrenia in some detail. Problems in research include diversity of the patient populations studied, as well as the possibility that decreased frontal glucose metabolism and blood flow ('hypofrontality') may be seen in chronic but not acute patients and are perhaps due to the effect of long-term antipsychotic therapy. Differences in statistical methods for data analysis, as well, may account for some of the variation in results. One of the difficulties in attempting to condense so much into such a small book is the inability to present conflicting viewpoints. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain imaging techniques
KW  - psychopharmacology
KW  - medical models
KW  - psychiatric illness
KW  - antipsychotic therapy
KW  - 1987
KW  - Brain
KW  - Drug Therapy
KW  - Psychopharmacology
KW  - Medical Model
KW  - Mental Disorders
KW  - 1987
U2  - Trimble, Michael R. (Ed). (1986); New Brain Imaging Techniques and Psychopharmacology; Oxford, England: Oxford University Press, 1986. 134 pp. $45.00; 0-19-261525-4.
DO  - 10.1037/027394
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06451-040
AN  - 2006-06451-040
AU  - Kleinman, Joel E.
T1  - An Introductory Text for Neuropsychologists.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/08//
VL  - 32
IS  - 8
SP  - 744
EP  - 745
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06451-040. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kleinman, Joel E.; Neuropathology Section, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Nervous System Disorders; Neuroanatomy; Neuropathology; Neuropsychological Assessment. Classification: Neuropsychological Assessment (2225); Neurological Disorders & Brain Damage (3297). Population: Human (10). Reviewed Item: Reitan, Ralph M.; Wolfson, Deborah. Neuroanatomy and Neuropathology: A Clinical Guide for Neuropsychologists=Tucson, AZ: Neuropsychology Press, 1985. 353 pp. $39.95; 1985. Page Count: 2. Issue Publication Date: Aug, 1987. 
AB  - Reviews the book, Neuroanatomy and Neuropathology: A Clinical Guide for Neuropsychologists by Ralph M. Reitan and Deborah Wolfson (1985). This textbook on neuroanatomy and neuropathology is written for neuropsychologists. Divided into four sections (introduction, neuroanatomy and neuropathology, diagnostic tests, and neurologic diseases), it is an excellent, although somewhat uneven, attempt. The introduction is concise, easy to read, and informative. The section on neuroanatomy and neuropathology is also well written. In addition, the diagrams are clear, useful, and accurate. In general, this is an excellent rating as a useful introduction for neuropsychologists in a field that needs their input. Insofar as it makes this possible, this book is a valuable and welcome addition to the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuroanatomy
KW  - neuropathology
KW  - diagnostic tests
KW  - neurologic diseases
KW  - 1987
KW  - Nervous System Disorders
KW  - Neuroanatomy
KW  - Neuropathology
KW  - Neuropsychological Assessment
KW  - 1987
U2  - Reitan, Ralph M.; Wolfson, Deborah. (1985); Neuroanatomy and Neuropathology: A Clinical Guide for Neuropsychologists; Tucson, AZ: Neuropsychology Press, 1985. 353 pp. $39.95; 0-934515-03-4.
DO  - 10.1037/027414
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Levinger, Louis F.
AU  - Lautenberger, James A.
T1  - Human protein binding to DNA sequences surrounding the human T-cell lymphotropic virus type-I long terminal repeat polyadenylation site.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/08/03/
VL  - 166
IS  - 3
M3  - Article
SP  - 519
EP  - 526
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The long terminal repeats (LTRs) of RNA tumor viruses, including human T-cell lymphotropic virus type I (HTLV-I), contain the control elements for expression of viral genes. Sequence-specific LTR-DNA-binding proteins could regulate viral functions. To search for such proteins we have used an <em>in vitro</em> non-denaturing polyacrylamide gel assay, with restriction fragments of the HTLV-I LTR and nuclear protein extracts from several HTLV-I-infected cell lines and an uninfected T-cell line, H9. Four DNA-binding activities were observed, including non-specific DNA-binding activity and at least two activities (forms I and II) which bind specifically to a <em>Hin</em>fI restriction fragment from nucleotides + 181 to + 334 relative to the transcription start site. DNA-binding activities I and II were partially resolved by ion-exchange chromatography and mapped by protection experiments to two 10-20-bp blocks surrounding the polyadenylation site at + 221. Of the cell lines tested, form II was abundantly found in C10/MJ, and forms I and IV were also found in C91/PL, C81-66-45, MT2 and H9 cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN binding
KW  - NUCLEOTIDE sequence
KW  - HTLV-I (Virus)
KW  - HTLV (Viruses)
KW  - RETROVIRUSES
KW  - ONCOGENIC viruses
KW  - RNA viruses
KW  - BIOCHEMISTRY
N1  - Accession Number: 13901772; Levinger, Louis F. 1 Lautenberger, James A. 2; Affiliation:  1: School of Life and Health Sciences, University of Delaware, Newark  2: Laboratory of Molecular Oncology, National Cancer Institute, Frederick; Source Info: 8/3/87, Vol. 166 Issue 3, p519; Subject Term: PROTEIN binding; Subject Term: NUCLEOTIDE sequence; Subject Term: HTLV-I (Virus); Subject Term: HTLV (Viruses); Subject Term: RETROVIRUSES; Subject Term: ONCOGENIC viruses; Subject Term: RNA viruses; Subject Term: BIOCHEMISTRY; Number of Pages: 8p; Illustrations: 4 Diagrams, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GARVER, JR., ROBERT I.
AU  - CHYTIL, ANNA
AU  - COURTNEY, MICHAEL
AU  - CRYSTAL, RONALD G.
T1  - Clonal Gene Therapy: Transplanted Mouse Fibroblast Clones Express Human α1-Antitrypsin Gene in Vivo.
JO  - Science
JF  - Science
Y1  - 1987/08/14/
VL  - 237
IS  - 4816
M3  - Article
SP  - 762
EP  - 764
SN  - 00368075
AB  - A retroviral vector was used to insert human α1-antitrypsin (α1AT) complementary DNA into the genome of mouse fibroblasts to create a clonal population of mouse fibroblasts secreting human α1AT. After demonstrating that this clone of fibroblasts produced α1AT after more than 100 population doublings in the absence of selection pressure, the done was transplanted into the peritoneal cavities of nude mice. When the animals were evaluated 4 weeks later, human α1AT was detected in both sera and the epithelial surface of the lungs. The transplanted clone of fibroblasts could be recovered from the peritoneal cavities of those mice and demonstrated to still be producing human α1AT. Thus, even after removal of selective pressure, a single clone of retroviral vector-infected celis that expressed an exogenous gene in vitro, continued to do so in vivo, and when recovered, continued to produce the product of the exogenous gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519539; GARVER, JR., ROBERT I. 1,2 CHYTIL, ANNA 1,2 COURTNEY, MICHAEL 1,2 CRYSTAL, RONALD G. 1,2; Affiliation:  1: Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892  2: Transgene SA, 11 Rue de Molsheim, 67000 Strasbourg, France; Source Info: 8/14/1987, Vol. 237 Issue 4816, p762; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MILLER, LOUIS H.
AU  - SAKAI, RICHARD K.
AU  - ROMANS, PATRICIA
AU  - GWADZ, ROBERT W.
AU  - KANTOFF, PHILIP
AU  - COON, HAYDEN G.
T1  - Stable Integration and Expression of a Bacterial Gene in the Mosquito Anopheles gambiae.
JO  - Science
JF  - Science
Y1  - 1987/08/14/
VL  - 237
IS  - 4816
M3  - Article
SP  - 779
EP  - 781
SN  - 00368075
AB  - Foreign DNA was successfully introduced into the germline of the African mosquito vector of malaria Anophelesgambiae. Stable integration of genes into the germlines of insects had been achieved previously only in Drosophila melanogaster and related species and required the use of the P element transposon. In these experiments with Anopheles gambiae, the plasmid pUChsneo was used, which contains the selectable marker neo gene flanked by P element inverted repeats. Mosquitoes injected with this plasmid were screened for resistance to the neomycin analog G-418. A single event of plasmid insertion was recovered. Integration appears to be stable and, thus far, resistance to G- 418 has been expressed for eight generations. The transformation event appears to be independent of P. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519563; MILLER, LOUIS H. 1 SAKAI, RICHARD K. 1 ROMANS, PATRICIA 1 GWADZ, ROBERT W. 1 KANTOFF, PHILIP 2 COON, HAYDEN G. 3; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892  2: Laboratorv of Molecular Hematology, National Heart, Lung and Blood Institute, Bethesda, MD 20892  3: Laboratorv of Genetics, National Cancer Institute, Bethesda, MD 20892; Source Info: 8/14/1987, Vol. 237 Issue 4816, p779; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Slade, John
AU  - Connolly, Gregory
AU  - Kazandjian, Vahe A.
AU  - Albanes, Demetrius
AU  - Jones, D. Yvonne
AU  - Micozzi, Marc S.
AU  - Martson, Margaret E.
AU  - Newman, David M.
AU  - Sorlie, Paul D.
T1  - Nicotine from Aerosol Rod.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/09//
VL  - 77
IS  - 9
M3  - Letter
SP  - 1229
EP  - 1229
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article “The delivery and uptake of nicotine from an aerosol rod," by D. W. Sepkovic that appeared in the previous issue of the journal "American Journal of Public Health."
KW  - LETTERS to the editor
KW  - NICOTINE
N1  - Accession Number: 4949820; Slade, John 1 Connolly, Gregory 2 Kazandjian, Vahe A. 3 Albanes, Demetrius 4 Jones, D. Yvonne 4 Micozzi, Marc S. 5 Martson, Margaret E. 6 Newman, David M. 7 Sorlie, Paul D. 8; Affiliation:  1: Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick 08903  2: Director, Division of Dental Health, Massachusetts Department of Public Health, Boston 02111  3: School of Public Health, University of Michigan, Ann Arbor  4: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, NIH, Bethesda, MD  5: Armed Forces Institutes of Pathology, Washington, DC  6: Office of the Director, Division of Cancer Prevention and Control, NCI, NIH, Bethesda, MD  7: Oak Orchard Community Health Center, 80 West Avenue, Brockport, NY 14420  8: Statistician (Health), Field Studies and Biometry Branch, Epidemiology and Biometry Research Program, Division of Epidemiology and Clinical Applications, NIH, NHLBI, Bethesda, MD 20892; Source Info: Sep87, Vol. 77 Issue 9, p1229; Subject Term: LETTERS to the editor; Subject Term: NICOTINE; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wetzel, Mary G.
T1  - A Natural History of Sex: The Ecology and Evolution of Sexual Behavior (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1987/09//Sep/Oct87
VL  - 75
IS  - 5
M3  - Book Review
SP  - 532
EP  - 533
SN  - 00030996
AB  - Reviews the book 'A Natural History of Sex: The Ecology and Evolution of Sexual Behavior,' by Adrian Forsyth.
KW  - Human sexuality
KW  - Nonfiction
KW  - Forsyth, Adrian
KW  - Natural History of Sex, A (Book)
N1  - Accession Number: 11317696; Wetzel, Mary G. 1; Affiliations: 1: Laboratory  of Vision Research, National Eye Institute, National Institutes of Health; Issue Info: Sep/Oct87, Vol. 75 Issue 5, p532; Subject Term: Human sexuality; Subject Term: Nonfiction; Reviews & Products: Natural History of Sex, A (Book); People: Forsyth, Adrian; Number of Pages: 21p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Wetzel, Mary G.
T1  - The Retina: A Model for Cell Biology Studies (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1987/09//Sep/Oct87
VL  - 75
IS  - 5
M3  - Book Review
SP  - 534
EP  - 534
SN  - 00030996
AB  - Reviews the book 'The Retina: A Model for Cell Biology Studies,' edited by Ruben Adler and Debora Faber.
KW  - Retina
KW  - Nonfiction
KW  - Retina, The (Book)
N1  - Accession Number: 11317697; Wetzel, Mary G. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; Issue Info: Sep/Oct87, Vol. 75 Issue 5, p534; Subject Term: Retina; Subject Term: Nonfiction; Reviews & Products: Retina, The (Book); Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Fries, L. F.
AU  - Siwik, S. A.
AU  - Malbran, A.
AU  - Frank, M. M.
T1  - Phagocytosis of target particles bearing C3b-IgG covalent complexes by human monocytes and polymorphonuclear leucocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1987/09//
VL  - 62
IS  - 1
M3  - Article
SP  - 45
EP  - 51
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Immunoglobulin G (IgG) provides an efficient acceptor site for nascent C3b, and complement activation on the surface of IgG-coated bacteria has been shown to generate significant numbers of C3b-IgG complexes. We have studied the relative efficiency of IgG alone, C3b-IgG complexes, and similar densities of IgG and C3b residues deposited independently, in mediating ingestion of sheep erythrocyte (E) targets by human phagocytes. Human 125I-C3b covalently bound to rabbit anti-Forssman IgG was generated as described elsewhere (Fries et al., 1985). E, EIgMC4b, or EIgMC4b3b (prepared with IgM antibody and purified complement components) were sensitized with radiolabelled anti-Forssman IgG or C3b-IgG heterodimers to generate targets beating IgG alone, C3b-IgG covalent complexes, or C3b and IgG in equivalent numbers but not bound to each other. Phagocytosis by monocytes and polymorphonuclear leucocytes (PMN) of targets bearing C3b-IgG was markedly enhanced relative to those bearing IgG alone, especially at levels of < 2000 opsonin residues/target cell. Uptake of C3b-IgG-hearing targets was also significantly more resistant to competitive inhibition by ambient monomeric IgG. Phagocytosis of EIgMCAb+C3b-IgG by monocytes was superior to the uptake of either EAC4b + IgG or EAC4b3b + IgG bearing equivalent amounts of C3b and IgG not in covalent complex (P < 0·05, n = 10). Similar results were obtained with PMN Thus, generation of C3b-IgG complexes in vivo may not only promote complement activation and enhance C3b deposition, but also produce a compound opsonic residue which is a more potent promoter of phagocytosis than an equal number of C3b and IgG residues randomly distributed relative to each other. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN G
KW  - ERYTHROCYTES
KW  - PHAGOCYTES
KW  - PHAGOCYTOSIS
KW  - MONOCYTES
KW  - NEUTROPHILS
N1  - Accession Number: 14015661; Fries, L. F. 1 Siwik, S. A. 1 Malbran, A. 1 Frank, M. M. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institutes of Health, Rockville Pike, Maryland, U.S.A.; Source Info: Sep87, Vol. 62 Issue 1, p45; Subject Term: IMMUNOGLOBULIN G; Subject Term: ERYTHROCYTES; Subject Term: PHAGOCYTES; Subject Term: PHAGOCYTOSIS; Subject Term: MONOCYTES; Subject Term: NEUTROPHILS; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - King, Haitung
AU  - Locke, Frances B.
T1  - Health Effects of Migration: U.S. Chinese In and Outside the Chinatown.
JO  - International Migration Review
JF  - International Migration Review
Y1  - 1987///Fall1987
VL  - 21
IS  - 3
M3  - Article
SP  - 555
EP  - 576
SN  - 01979183
AB  - A comparison of mortality among New York and San Francisco Chinatown residents and other Chinese Americans indicates that there is no clear relationship between migration and health risks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Migration Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - EMIGRATION & immigration
KW  - DEMOGRAPHY
KW  - POPULATION
KW  - DEATH
KW  - CHINESE Americans
KW  - CHINA
KW  - IMMIGRATION AND MIGRATION
N1  - Accession Number: 16498655; King, Haitung 1; Locke, Frances B. 2; Affiliations: 1 : National Cancer Institute and Georgetown University.; 2 : National Cancer Institute.;  Source Info: Fall1987, Vol. 21 Issue 3, p555; Historical Period: 1965 to 1975; Subject Term: HEALTH; Subject Term: EMIGRATION & immigration; Subject Term: DEMOGRAPHY; Subject Term: POPULATION; Subject Term: DEATH; Subject Term: CHINESE Americans; Subject: CHINA; Author-Supplied Keyword: IMMIGRATION AND MIGRATION; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - ahl
ER  - 

TY  - JOUR
AU  - Piegorsch, Walter W.
T1  - Model Robustness for Simultaneous Confidence Bands.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1987/09//
VL  - 82
IS  - 399
M3  - Article
SP  - 879
SN  - 01621459
AB  - Confidence bands for the simple linear model are examined to assess their degrees of robustness to departures from the model. All calculations are made under an interval constraint on the range of interest for the predictor variable. The true model is taken to be a quadratic polynomial, and departure from the linear case is considered in terms of increasing magnitude of a curvature parameter. Proposed measures of robustness include the actual coverage probability under the true model and a measure of percentage coverage over the predictor variable axis when the band fails to cover the true quadratic model. The different band functions considered include hyperbolic bands constructed from Scheffe's S method, linear-segmented bands, and fixed-width (minimax) and minimax-regret bands. In terms of preserving coverage probability under quadratic misspecification, the fixed-width and linear-segment bands perform best, the former being preferred when the constraint interval on the predictor variable is small. When coverage is lost over some portion of the constraint interval, the fixed-width bands are also shown to preserve the greatest percentage of covered (predictor) axis values. The favorable performance of the fixed-width bands may be due to their generally wider, more rigid shape, relative to more curvilinear competitors. This may allow the bands to retain more extreme quadratic misspecifications than other bands. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROBABILITY theory
KW  - REGRESSION analysis
KW  - MATHEMATICAL models
KW  - LINEAR models (Statistics)
KW  - SIMULATION methods & models
KW  - QUADRATIC equations
KW  - VARIABLES (Mathematics)
KW  - ROBUST control
KW  - Coverage probability
KW  - Mean axis coverage
KW  - Quadratic regression
KW  - Simple linear regression.
N1  - Accession Number: 4605941; Piegorsch, Walter W. 1; Affiliations: 1: Mathematical Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Sep87, Vol. 82 Issue 399, p879; Thesaurus Term: PROBABILITY theory; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: SIMULATION methods & models; Subject Term: QUADRATIC equations; Subject Term: VARIABLES (Mathematics); Subject Term: ROBUST control; Author-Supplied Keyword: Coverage probability; Author-Supplied Keyword: Mean axis coverage; Author-Supplied Keyword: Quadratic regression; Author-Supplied Keyword: Simple linear regression.; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rifkind, Basil M.
T1  - Diet, Cholesterol and coronary heart disease: the Lipid Research Clinics Program.
JO  - Proceedings of the Nutrition Society
JF  - Proceedings of the Nutrition Society
Y1  - 1987/09//
VL  - 46
IS  - 3
M3  - Article
SP  - 367
EP  - 372
SN  - 00296651
N1  - Accession Number: 56764240; Rifkind, Basil M. 1; Affiliations: 1: Lipid Metabolism–Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; Issue Info: Sep1987, Vol. 46 Issue 3, p367; Number of Pages: 6p; Document Type: Article
L3  - 10.1079/PNS19870050
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lievrouw, Leah A.
AU  - Rogers, Everett M.
AU  - Lowe, Charles U.
AU  - Nadel, Edward
T1  - 
JO  - Social Networks
JF  - Social Networks
J1  - Social Networks
PY  - 1987/09//
Y1  - 1987/09//
VL  - 9
IS  - 3
M3  - Article
SP  - 217
SN  - 03788733
AB  - A triangulation strategy, employing a number of network analysis techniques, was implemented in the study of a single social network of biomedical scientists specializing in lipid metabolism research. Here we present the results of co-word analysis of grants awarded to these scientists by the National Institutes of Health, network analysis (NEGOPY) and factor analysis of the scientists' responses on a sociometric roster instrument, preliminary results of a co-citation analysis of their publications, and qualitative analysis of their responses to interviews and questionnaires. The findings are discussed in light of the relative information that the various techniques contribute to the understanding of the social relationships among the members of this scientific speciality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Networks is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL networksQUALITATIVE researchMEDICAL scientistsSOCIAL interactionUNIVERSITIES & collegesINTERVIEWS
N1  - Accession Number: 17189673; Issue Information: ; Subject Term: SOCIAL networks; Subject Term: QUALITATIVE research; Subject Term: MEDICAL scientists; Subject Term: SOCIAL interaction; Subject Term: UNIVERSITIES & colleges; Subject Term: INTERVIEWS; Subject Term: ; Number of Pages: 32p; ; Document Type: Article; 
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DP  - EBSCOhost
DB  - bwh
ER  - 

TY  - JOUR
ID  - 2006-06452-036
AN  - 2006-06452-036
AU  - Myslobodsky, Michael S.
T1  - The Iceberg Above the Waterline.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/09//
VL  - 32
IS  - 9
SP  - 818
EP  - 819
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06452-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Myslobodsky, Michael S.; Clinical Brain Disorder Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Consciousness States. Classification: Consciousness States (2380). Population: Human (10). Reviewed Item: Wolman, Benjamin B. (Ed); Ullman, Montague (Ed). Handbook of States of Consciousness=New York: Van Nostrand Reinhold, 1986. 672 pp. $54.50; 1986. References Available: Y. Page Count: 2. Issue Publication Date: Sep, 1987. 
AB  - Reviews the book, Handbook of States of Consciousness edited by Benjamin B. Wolman and Montague Ullman (1986). The promise of this book is to give up-to-date information on the entire field of human consciousness. However, this volume was a disappointment to this reviewer, as it did not stand to this promise on either count. Yet, it would be naive to look for a contribution related to the recent thinking and/or research on consciousness in developmental psychobiology, artificial intelligence, linguistics, sensory psychology, anesthesiology, neurology, and neuropsychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - consciousness states
KW  - 1987
KW  - Consciousness States
KW  - 1987
U2  - Wolman, Benjamin B. (Ed); Ullman, Montague (Ed). (1986); Handbook of States of Consciousness; New York: Van Nostrand Reinhold, 1986. 672 pp. $54.50; 0-442-29456-5.
DO  - 10.1037/027477
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06452-036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06452-045
AN  - 2006-06452-045
AU  - Hadley, Suzanne W.
T1  - A Therapy Catalog.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/09//
VL  - 32
IS  - 9
SP  - 826
EP  - 827
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06452-045. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hadley, Suzanne W.; Extramural Policy Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychotherapists; Treatment. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Kutash, Irwin L. (Ed); Wolf, Alexander (Ed). Psychotherapist's Casebook: Theory and Technique in the Practice of Modern Therapies=San Francisco: Jossey-Bass, 1986. 552 pp. $39.95; 1986. Page Count: 2. Issue Publication Date: Sep, 1987. 
AB  - Reviews the book, Psychotherapist's Casebook: Theory and Technique in the Practice of Modern Therapies edited by Irwin L. Kutash and Alexander Wolf (1986). The editors, Kutash and Wolf, were judicious in identifying the treatment approaches that would be represented. The gamut of major modalities are included in the book, with a sufficient level of subtyping so that important variations within broad approaches are treated separately. At the same time, the pitfall seen in other edited therapy compendia is avoided, namely, the inclusion of relatively rare, esoteric forms of treatment that have little interest for readers of a work such as this. The editors structured the task of the contributors to this volume exceedingly well. This truly is a 'casebook', the cases are engaging, readable, and revealing. The explication of theoretical substrates was kept to a minimum, with the case studies themselves used as a primary source of substantive input. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - therapies
KW  - psychotherapists
KW  - 1987
KW  - Psychotherapists
KW  - Treatment
KW  - 1987
U2  - Kutash, Irwin L. (Ed); Wolf, Alexander (Ed). (1986); Psychotherapist's Casebook: Theory and Technique in the Practice of Modern Therapies; San Francisco: Jossey-Bass, 1986. 552 pp. $39.95; 0-87589-685-5.
DO  - 10.1037/027486
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - REYNOLDS, STEVEN H.
AU  - STOWERS, SHARI J.
AU  - PATTERSON, RACHEL M.
AU  - MARONPOT, ROBERT R.
AU  - AARONSON, STUART A.
AU  - ANDERSON, MARSHALL W.
T1  - Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications for Risk Assessment.
JO  - Science
JF  - Science
Y1  - 1987/09/11/
VL  - 237
IS  - 4820
M3  - Article
SP  - 1309
EP  - 1316
SN  - 00368075
AB  - The validity of mouse liver tumor end points in assessing the potential hazards of chemical exposure to humans is a controversial but important issue, since liver neoplasia in mice is the most frequent tumor target tissue end point in 2-year carcinogenicity studies. The ability to distinguish between promotion of background tumors versus a genotoxic mechanism of tumor initaton by chemical treatment would aid in the interpretation of rodent carcinogenesis data. Activated oncogenes in chemically induced and spontaneously occurring mouse liver tumors were examined and compared as one approach to determine the mechanism by which chemical treatment caused an increased incidence of mouse liver tumors. Data suggest that furan and furfural caused an increased incidence in mouse liver tumors at least in part by induction of novel weakly activating point mutations in ras genes even though both chemicals did not induce mutations in Salmonella assays. In addition to ras oncogenes, two activated raf genes and four non-ras transforming genes were detected. The B6C3F1 mouse liver may thus provide a sensitive assay system to detect various dasses of proto-oncogenes that are susceptible to activation by carcinogenic insult. As illustrated with mouse liver tumors, analysis of activated oncogenes in spontaneously occuring and chemically induced rodent tumors will provide information at a molecular level to aid in the use of rodent carcinogenesis data for risk assessment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519592; REYNOLDS, STEVEN H. 1 STOWERS, SHARI J. 1 PATTERSON, RACHEL M. 1 MARONPOT, ROBERT R. 2 AARONSON, STUART A. 3 ANDERSON, MARSHALL W. 1; Affiliation:  1: Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Post Office Box 12233, Research Triangle Park, NC 27709  2: National Toxicologv Program, National Institute of Environmental Health Sciences, Post Office Box 12223, Research Triangle Park, NC 27709  3: Laboratory of Cellular and Molecular Biology, National Institutes of Health, Bethesda, MD 20205; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1309; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - NERENBERG, MICHAEL
AU  - HINRICHS, STEVEN H.
AU  - REYNOLDS, R. KAY
AU  - KHOURY, GEORGE
AU  - JAY, GILBERT
T1  - The tat Gene of Human T-Lymphotropic virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice.
JO  - Science
JF  - Science
Y1  - 1987/09/11/
VL  - 237
IS  - 4820
M3  - Article
SP  - 1324
EP  - 1329
SN  - 00368075
AB  - Human T-lymphotropic virus type 1 (HTLV-1) is a suspected causative agent of adult T-cell leukemia. One of the viral genes encodes a protein (tat) that not only results in transactivation of viral gene expression but may also regulate the expression of certain cellular genes that are important for cell growth. Transgenic mice that expressed the authentic tat protein under the control of the HTLV-1 long terminal-repeat were generated, and cell types that are permissive for the viral promoter and the effects ofthe tat gene on these cells were studied. Three of eight founder mice with high levels of expression of the transgene in muscle were bred and then analyzed. All developed soft tissue tumors at multiple sites between 13 to 17 weeks of age. This phenotype was transmitted to nine of nine offspring that inherited the tat gene and were available for analysis. The remanig five founders expressed the transgene in the thymus, as well as in muscle. This second group of mice all exhibited extensive thymic depletion and growth retardation; in all of these mice, death occurred between 3 to 6 weeks ofage before tumors became macroscopically visible. The tat gene under the control of the HTLV-1 regulatory region showed tissuespecific expression and the tat protein efficiently induced mesenchymal tumors. The data establish tat as an oncogenic protein and HTLV-1 as a transforming virus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519588; NERENBERG, MICHAEL 1 HINRICHS, STEVEN H. 1 REYNOLDS, R. KAY 1 KHOURY, GEORGE 1 JAY, GILBERT 1; Affiliation:  1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1324; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MUSTOE, THOMAS A.
AU  - PIERCE, GLENN F.
AU  - THOMASON, ARLEN
AU  - GRAMATES, PEGGY
AU  - SPORN, MICHAEL B.
AU  - DEUEL, THOMAS F.
T1  - Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β.
JO  - Science
JF  - Science
Y1  - 1987/09/11/
VL  - 237
IS  - 4820
M3  - Article
SP  - 1333
EP  - 1336
SN  - 00368075
AB  - The role of polypeptide growth factors in the processes ofinflammation and repair was investigated by analyzing the influence of transforming growth factor-β (TGF-β), applied directly to linear iniasions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-β on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production ofthe wound and application of TGF-β. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-β. TGF-β is thus a potent pharmacologic agent that can accelerate wound healing in rats. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519587; MUSTOE, THOMAS A. 1 PIERCE, GLENN F. 2 THOMASON, ARLEN 3 GRAMATES, PEGGY 1 SPORN, MICHAEL B. 4 DEUEL, THOMAS F. 5; Affiliation:  1: Department of Surgery, Washington University Medical Center, St. Louis, MO 63110  2: Departments of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110  3: Amgen, Inc., Thousand Oaks, CA 91320  4: Laboratory for Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892  5: Departments of Medicine and Biological Chemistry, Washington University Medical Center, St. Louis, MO 63110; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1333; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HINRICHS, STEVEN H.
AU  - NERENBERG, MICHAEL
AU  - REYNOLDS, R. KAY
AU  - KHOURY, GEORGE
AU  - JAY, GILBERT
T1  - A Transgenic Mouse Model for Human Neurofibromatosis.
JO  - Science
JF  - Science
Y1  - 1987/09/11/
VL  - 237
IS  - 4820
M3  - Article
SP  - 1340
EP  - 1343
SN  - 00368075
AB  - Human T-lymphotropic virus type 1 (HTLV-1) has been associated with the neurologic disorder tropical spastic paraparesis and possibly with multiple sclerosis. The tat gene of HTLV-1 under control of its own long terminal repeat is capable of inducng tumors in transgenic mice. The morphologic and biologic properties of these tumors indicate their dose resemblance to human neurofibromatosis (von Reklinghausen's disease), the most common single gene disorder to affect the nervous system. The high spontaneous incidence ofthis disease, together with the diverse clinical and pathologic features associated with it, suggests that environmental factors may account for some of the observed cases. Multiple tumors developed simultaneously in the transgenic tat mice at approximately 3 months of age, and the phenotype was successfully passed through three generations. The tumors arise from the nerve sheaths of peripheral nerves and are composed of perineural cells and fibroblasts. Tumor cells from these mice adapt easily to propagation in culture and continue to express the tat protein in significant amounts. When transplanted into nude mice, these cultured cells efficiently induce tumors. Evidence of HIV-1 infection in patients with neural and other soft tissue tumors is needed in order to establish a link between infection by this human retrovirus and von Recklinghausen's disease and other nonlymphoid tumors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87519577; HINRICHS, STEVEN H. 1 NERENBERG, MICHAEL 1 REYNOLDS, R. KAY 1 KHOURY, GEORGE 1 JAY, GILBERT 1; Affiliation:  1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1340; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rogan, Walter J.
AU  - Gladen, Beth C.
AU  - McKinney, James D.
AU  - Carreras, Nancy
AU  - Hardy, Pam
AU  - Thullen, James
AU  - Tingelstad, Jon
AU  - Tully, Mary
T1  - Polychlorinated Biphenyls (PCBs) and Dichlorodiphelyl Dichloroethene (DDE) in Human Milk: Effects on Growth, Morbidity, and Duration of Lactation.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/10//
VL  - 77
IS  - 10
M3  - Article
SP  - 1294
EP  - 1297
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We followed 858 children from birth to one year of age to determine whether the presence of polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in breast milk affected their growth or health. Neither chemical showed an adverse effect on weight or frequency of physician visits for various illnesses, although differences were seen between breast-fed and bottle-fed children, with bottle-fed children being heavier and having more frequent gastroenteritis and otitis media. Children of mothers with higher levels of DDE were breast-fed for markedly shorter times, but adjustments for possible confounders and biases did not change the findings. In absence of any apparent effect on the health of the children, we speculate that DDE may be interfering with the mother's ability to lactate possibly because of its estrogenic properties. (Am J Public Health 1987: 77:1294-1297.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POLYCHLORINATED biphenyls
KW  - DICHLOROETHYLENE
KW  - BREAST milk
KW  - GROWTH factors
KW  - DISEASES
KW  - LACTATION
KW  - BREASTFEEDING (Humans)
KW  - BOTTLE feeding
KW  - ADIPOSE tissues
KW  - CASE studies
N1  - Accession Number: 4949835; Rogan, Walter J. 1,2,3,4,5,6 Gladen, Beth C. 1,2,3,4,5,6 McKinney, James D. 1,2,3,4,5,6 Carreras, Nancy 1,2,3,4,5,6 Hardy, Pam 1,2,3,4,5,6 Thullen, James 1,2,3,4,5,6 Tingelstad, Jon 1,2,3,4,5,6 Tully, Mary 7; Affiliation:  1: Epidemiology and the Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences. Research Triangle Park, NC.  2: Statistics and the Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences. Research Triangle Park, NC.  3: Biomathematics Branches and the Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences. Research Triangle Park, NC.  4: Durham Women's Clinic, Durham, NC.  5: Department of Pediatrics, East Carolina University School of Medicine, Greenville, NC.  6: Department of Pediatrics, University of North Carolina School of Medicine Chapel Hill, NC.  7: Wake Area Health Education Center, Raleigh, NC; Source Info: Oct87, Vol. 77 Issue 10, p1294; Subject Term: POLYCHLORINATED biphenyls; Subject Term: DICHLOROETHYLENE; Subject Term: BREAST milk; Subject Term: GROWTH factors; Subject Term: DISEASES; Subject Term: LACTATION; Subject Term: BREASTFEEDING (Humans); Subject Term: BOTTLE feeding; Subject Term: ADIPOSE tissues; Subject Term: CASE studies; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Connor, Amy B.
AU  - Burgio, Louis D.
AU  - Butler, Frieda A.
T1  - AN OBSERVATIONAL ANALYSIS OF SELF-STIMULATORY BEHAVIOR OF OLDER ADULTS IN A NURSING HOME.
JO  - Behavioral Residential Treatment
JF  - Behavioral Residential Treatment
Y1  - 1987/10//
VL  - 2
IS  - 4
M3  - Article
SP  - 189
EP  - 197
PB  - John Wiley & Sons, Inc.
SN  - 08845581
AB  - Self-stimulatory behavior is described as a class of stereotyped and repetitive behaviors. This behavior often warrants concern because it can interfere with the learning and maintenance of more appropriate functional behaviors. In the present study, several topographies of self-stimulation were generated and the behavior of three older adult nursing home patients was observed for six weeks. Self-stimulation was high rate in all three subjects, and the manifestation of the behavior was idiosyncratic. Potential etiological factors and implications for treatment were discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Behavioral Residential Treatment is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OLDER people
KW  - HUMAN behavior
KW  - MEDICAL geography
KW  - NURSING home patients
KW  - IDIOSYNCRATIC drug reactions
KW  - SCHIZOPHRENICS
N1  - Accession Number: 12212798; Connor, Amy B. 1 Burgio, Louis D. 1 Butler, Frieda A. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 and Howard University College of Nursing, Washigton, DC 20001; Source Info: Oct87, Vol. 2 Issue 4, p189; Subject Term: OLDER people; Subject Term: HUMAN behavior; Subject Term: MEDICAL geography; Subject Term: NURSING home patients; Subject Term: IDIOSYNCRATIC drug reactions; Subject Term: SCHIZOPHRENICS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Suske, Guntram
AU  - Mengel, Thomas
AU  - Cordingley, Mike
AU  - Kadenbach, Bernhard
T1  - Molecular cloning and further characterization of cDNAs for rat nuclear-encoded cytochrome c oxidase summits VIc and VIII.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/10//10/1/87
VL  - 168
IS  - 1
M3  - Article
SP  - 233
EP  - 237
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A cDNA library was constructed from poly(A)-rich RNA of H35 rat hepatoma cells by insertion into &lambd;gt11. Screening with an antiserum to rat liver holocytochrome-c oxidase yielded fifteen different recombinant clones. Eight clones were identified using monospecific antisera to individual subunits of the rat fiver enzyme. The cDNA clones coding for subunits VIc and VIII were further characterized by DNA sequence analysis after subcloning in pUC8 and M13 rap9. The deduced amino acid sequences show 80% and 60% homology to the corresponding bovine heart subunits, respectively. From the nucleotide sequences we can conclude that subunit VIc is not synthesized as a larger precursor molecule like most other mitochondrial proteins. The size of the mRNAs coding for subunits VIc and VIII is about 450 nucleotides, as revealed by Northern blot analysis with RNAs from different tissues. The clones were further used as probes for Southern blotting. Restricted high-molecular-mass DNA showed a complex pattern of bands indicating multigene families for both subunits in the rat genome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIRCULAR DNA
KW  - GENE libraries
KW  - RECOMBINANT DNA
KW  - HEPATOMA
KW  - LIVER cells
KW  - ANTI-antibodies
KW  - AMINO acid sequence
N1  - Accession Number: 13860538; Suske, Guntram 1 Mengel, Thomas 1 Cordingley, Mike 2 Kadenbach, Bernhard 1; Affiliation:  1: Biochemie, Fachbereich Chemie der Philipps-Universität, Marburg  2: National Institutes of Health, Bethesda, Maryland; Source Info: 10/1/87, Vol. 168 Issue 1, p233; Subject Term: CIRCULAR DNA; Subject Term: GENE libraries; Subject Term: RECOMBINANT DNA; Subject Term: HEPATOMA; Subject Term: LIVER cells; Subject Term: ANTI-antibodies; Subject Term: AMINO acid sequence; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Powers, Douglas C.
AU  - Sears, Stephen D.
T1  - Influenza, pneumonia, tetanus: How effective is vaccination?
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1987/10//
VL  - 42
IS  - 10
M3  - Article
SP  - 81
EP  - 90
SN  - 0016867X
N1  - Accession Number: 15868571; Powers, Douglas C. 1,2; Sears, Stephen D. 3,4; Source Information: Oct1987, Vol. 42 Issue 10, p81; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3146
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Stupak, Ronald J.
AU  - Moore, Jerry E.
T1  - THE PRACTICE OF MANAGING ORGANIZATION DEVELOPMENT IN PUBLIC SECTOR ORGANIZATIONS; REASSESSMENTS, REALITIES, AND REWARDS.
JO  - International Journal of Public Administration
JF  - International Journal of Public Administration
Y1  - 1987/10//
VL  - 10
IS  - 3
M3  - Article
SP  - 131
EP  - 153
SN  - 01900692
AB  - This article examines some of the questions that have been raised by many scholars, consultants, and managers regarding the relevance of organization development (OD) to public sector organizations. Some of the questions addressed include: To what extent is OD- as a strategy for planning and implementing change--relevant to public sector management? What are the salient differences between public and private sector organizations that can affect the practice and effectiveness of OD? What strategies can be used to accommodate these differences? How can the practice of OD be effectively managed in public sector organizations? What kinds of modifications in the field of OD are necessary to enhance its future relevance to public sector organizations? What are the possible impacts of the Reagan cutback management philosophy for OD in the public sector? After exhaustive analysis, it becomes clear that the public manager who develops a fair understanding of the values, assumptions, and technologies of OD, and the OD consultant who demonstrates a clear understanding of the unique nature of the public sector environment, can successfully manage OD in public organizations if they can set modest goals, accept unexpected setbacks, and be satisfied with tackling manageable issues as opposed to attempting to change the entire system at a fundamental level. A central theme of American public administration is that government can and should be run like a business enterprise. Since the earliest days of the American political system, reform efforts have been guided by an enduring belief in what has been termed the "business analogy." That is, the nature, problems, and general functions of public and corporate management are viewed as being essentially analogous. Therefore, the assumption is made that the relatively well developed body of ideas and practices of corporate management can and should be applied to the management of government. Public management can and should be more business like. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Public Administration is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ORGANIZATIONAL change
KW  - PUBLIC sector
KW  - ASSESSMENT centers (Personnel management procedure)
KW  - MANAGEMENT science
KW  - PUBLIC administration
KW  - INDUSTRIAL management
N1  - Accession Number: 11951532; Stupak, Ronald J. 1; Moore, Jerry E. 2; Affiliations: 1: Director and Professor Washington Public Affairs Center School of Public Administration University of Southern California.; 2: Senior Management Analyst Workforce Effectiveness Staff Division of Management Policy National Institutes of Health.; Issue Info: 1987, Vol. 10 Issue 3, p131; Thesaurus Term: ORGANIZATIONAL change; Thesaurus Term: PUBLIC sector; Thesaurus Term: ASSESSMENT centers (Personnel management procedure); Thesaurus Term: MANAGEMENT science; Thesaurus Term: PUBLIC administration; Thesaurus Term: INDUSTRIAL management; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 23p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Rogers, George
AU  - Martinet, Nadine
AU  - Steinert, Peter
AU  - Wynn, Peter
AU  - Roop, Dennis
AU  - Kilkenny, Anne
AU  - Morgan, David
AU  - Yuspa, Stuart H.
T1  - Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/10//
VL  - 89
IS  - 4
M3  - Article
SP  - 369
EP  - 379
SN  - 0022202X
AB  - Techniques are described for the isolation and cultivation of functionally intact mouse hair follicles. Follicles were isolated by collagenase digestion of dermis from 5-day-old mice and purified by differential centrifugation and filtration. Purified follicles were cultured in a Type 1 collagen matrix using Medium 199 and 8% fetal calf serum as the basic nutrient. Viability of follicles was maintained in culture Since the cultures incorporated thymidine into DNA and methionine into proteins for at least 7 days. Further- more, follicles isolated from the collagen matrix after 7 days could reattach to a plastic culture substrate or be further cultivated in a fresh collagen matrix. Functional integrity of cultured follicles was maintained since some follicle-specific cytoskeletal proteins were synthesized in vitro, and follicles isolated from the collagen matrix after 7 days formed a haired skin when recombined with dermal fibroblasts and grafted to a skin site on nude mice. Only a minority of follicles appeared to produce a mature hair shaft in vitro by morphologic criteria, however, and synthesis of the total complement of hair proteins was not observed. Cholera toxin was a strong mitogen for cultured follicles, whereas epidermal growth factor was slightly mitogenic. Epidermal growth factor stimulated the release of a Type 1 collagenase by follicle cells, however. This model system provides an opportunity for the systematic analysis of factors required for the induction of hair growth and the underlying physiology of hair follicle development. This model should also be useful for studying the role of the hair follicle in skin carcinogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR
KW  - COLLAGEN
KW  - THYMIDINE
KW  - DNA
KW  - DERMIS
KW  - FIBROBLASTS
N1  - Accession Number: 12471760; Rogers, George 1 Martinet, Nadine 2 Steinert, Peter 3 Wynn, Peter 4 Roop, Dennis 5 Kilkenny, Anne 5 Morgan, David 5 Yuspa, Stuart H. 5; Affiliation:  1: Department of Biochemistry, University of Adelaide, Adelaide, South Australia.  2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Cancer Institute, Bethesda, Maryland, U.S.A.  3: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  4: Ian Clunies Ross Animal Research Laboratories Division of Animal Production, CSIRO, Blacktown, N. S. W., Australia.  5: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Oct87, Vol. 89 Issue 4, p369; Subject Term: HAIR; Subject Term: COLLAGEN; Subject Term: THYMIDINE; Subject Term: DNA; Subject Term: DERMIS; Subject Term: FIBROBLASTS; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1523-1747.ep12471760
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06441-020
AN  - 2006-06441-020
AU  - Crawley, Jacqueline N.
T1  - GABAergic Antidepressants.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1987/10//
VL  - 32
IS  - 10
SP  - 876
EP  - 877
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06441-020. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Crawley, Jacqueline N.; Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Affective Disorders; Emotional States; Gamma Aminobutyric Acid. Minor Descriptor: Psychopharmacology. Classification: Affective Disorders (3211); Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Bartholini, G. (Ed); Lloyd, K. G. (Ed); Morselli, P. L. (Ed). GABA and Mood Disorders: Experimental and Clinical Research=New York: Raven Press, 1986. 222 pp. $29.50; 1986. Page Count: 2. Issue Publication Date: Oct, 1987. 
AB  - Reviews the book, GABA and Mood Disorders: Experimental and Clinical Research edited by G. Bartholini, K. G. Lloyd, and P. L. Morselli (1986). The volume begins with the rationale for studying gamma aminobutyric acid (GABA) with respect to human depression, including a review of the monoamine transmitters classically linked to depression, the structure of the GABA-benzodiazepine-chloride channel receptor complex, and the subtypes of highand low-affinity GABA receptors. Although this volume is obviously a product of a pharmaceutical company committed to promoting its new line of drugs, it contains a fascinating story of how a new drug comes into being. It is refreshing to read an account of the way psychopharmacological agents are developed today. This volume gives the reader the reassuring impression that new drugs will be more specific, with fewer deleterious side effects, and more efficacious against mental illnesses in future generations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mood disorders
KW  - clinical research
KW  - experimental research
KW  - antidepressants
KW  - gamma aminobutyric acid antagonists
KW  - 1987
KW  - Affective Disorders
KW  - Emotional States
KW  - Gamma Aminobutyric Acid
KW  - Psychopharmacology
KW  - 1987
U2  - Bartholini, G. (Ed); Lloyd, K. G. (Ed); Morselli, P. L. (Ed). (1986); GABA and Mood Disorders: Experimental and Clinical Research; New York: Raven Press, 1986. 222 pp. $29.50; 0-88167-129-0.
DO  - 10.1037/026430
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Lanza, Elaine
AU  - Jones, D. Yvonne
AU  - Block, Gladys
AU  - Kessler, Larry
T1  - Dietary fiber intake in the US population.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/11//
VL  - 46
IS  - 5
M3  - Article
SP  - 790
EP  - 797
SN  - 00029165
AB  - Twenty-four hour recall data from adults interviewed in the Second National Health and Nutrition Examination Survey, NHANES II, were used as the basis to estimate total dietary fiber intake in the United States. Food fiber values were calculated for the 2500 foods in NHANES II in two ways: 1) using fiber values compiled from the literature by NCI and 2) values based on the Southgate methodology. Mean dietary fiber intake in the US adult population (> 19 y of age) is 11.1 g/d using the first set of values and 13.3 g/d according to Southgate values. On a per 1000 kcal basis, women consume more dietary fiber (6.5 g/1000 kcal) than men (5.5 g/1000 kcal) at every age. Fiber intake by geographic region, age, race, and sex is discussed. Our study indicates that dietary fiber intake in the United States is considerably lower than that previously reported. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Nutrition
KW  - Fiber in human nutrition
KW  - Age groups
KW  - Body mass index
KW  - Physical fitness
KW  - Dietary fiber
KW  - nutrient intakes
N1  - Accession Number: 91710887; Lanza, Elaine 1; Jones, D. Yvonne 1; Block, Gladys 1; Kessler, Larry 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, MD; Issue Info: Nov1987, Vol. 46 Issue 5, p790; Thesaurus Term: Nutrition; Subject Term: Fiber in human nutrition; Subject Term: Age groups; Subject Term: Body mass index; Subject Term: Physical fitness; Author-Supplied Keyword: Dietary fiber; Author-Supplied Keyword: nutrient intakes; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Milton, Roy C.
AU  - Reddy, Vinodini
AU  - Naidu, A. N.
T1  - Mild vitamin A deficiency and childhood morbidity--an Indian experience.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/11//
VL  - 46
IS  - 5
M3  - Article
SP  - 827
EP  - 829
SN  - 00029165
AB  - Over 1500 preschool urban Indian children were followed weekly for morbidity from 12 to 18 mo. Examination for mild xerophthalmia (Bitot's spots and night blindness) was done initially and at 6 and 12 mo. Children with mild xerophthalmia at the start of a 6-mo interval developed respiratory disease in the interval twice as often as children with normal eyes at the start of the interval. No association was found between mild xerophthalmia and incidence of diarrhea. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Xerophthalmia
KW  - Respiratory diseases
KW  - Vitamin A deficiency
KW  - Diarrhea
KW  - Summer diseases
KW  - School children -- India
KW  - diarrhea
KW  - incidence
KW  - respiratory disease
KW  - vitamin A deficiency
N1  - Accession Number: 91710892; Milton, Roy C. 1; Reddy, Vinodini 2; Naidu, A. N. 2; Affiliations: 1: National Eye Institute, Bethesda, MD; 2: National Institute of Nutrition, Hyderabad, India; Issue Info: Nov1987, Vol. 46 Issue 5, p827; Subject Term: Xerophthalmia; Subject Term: Respiratory diseases; Subject Term: Vitamin A deficiency; Subject Term: Diarrhea; Subject Term: Summer diseases; Subject Term: School children -- India; Author-Supplied Keyword: diarrhea; Author-Supplied Keyword: incidence; Author-Supplied Keyword: respiratory disease; Author-Supplied Keyword: vitamin A deficiency; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Digregorio, Gayle
AU  - Suomi, Stephen J.
AU  - Eisele, Carole E.
AU  - Chapman, Sharon A.
T1  - Reactions of Nuclear-Family--Reared Rhesus Macaques to the Births of Younger Siblings.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1987/11//
VL  - 13
IS  - 3
M3  - Article
SP  - 231
EP  - 253
SN  - 02752565
AB  - A group of juvenile rhesus macaques (Macaca mulatta) living in a nuclear-family laboratory environment was studied to determine their responses to the births of siblings. The frequencies of interactions with family members (mothers, fathers, and new siblings) and nonfamily (peers, unrelated infants, and unrelated adults) were studied over both the year preceding and the year following sibling birth. The frequencies of specific behaviors in each of those interactions and the frequencies of interactions in each area of the nuclear-family unit (home cage, play area, or other families' cage) were also examined. After new siblings arrived, several measures of interactions with mothers, fathers, and new siblings increased significantly; by contrast inter-actions with peers decreased substantially over the post-birth year. Although the frequency of interactions in home cages remained stable over the 2-year period, interactions outside of the subjects' home cages decreased significantly after siblings were born. An additional subject group whose mothers became pregnant but failed to deliver viable offspring showed no significant changes in total levels of interactions with peers; they did, however, exhibit increases in some interactions with unrelated infants and adults. Female juveniles interacted with new siblings siginificantly more often than did males when siblings were less than 6 months old, but as siblings grew older (6-12 months), females' levels of interaction with them felt to a level equal to that of males. In the nuclear-family social structure, the birth of a sibling resulted in an increased emphasis on family interactions at the expense of peer interactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHESUS monkey
KW  - BROTHERS & sisters
KW  - NUCLEAR families
KW  - ANIMAL young
KW  - PREGNANCY in animals
KW  - PEERS
KW  - kinship
KW  - peer interactions .
KW  - Rhesus macaque
KW  - siblings
KW  - social behavior
N1  - Accession Number: 12363629; Digregorio, Gayle 1 Suomi, Stephen J. 1 Eisele, Carole E. 1 Chapman, Sharon A. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human, Development, Bethesda, Maryland.; Source Info: 1987, Vol. 13 Issue 3, p231; Subject Term: RHESUS monkey; Subject Term: BROTHERS & sisters; Subject Term: NUCLEAR families; Subject Term: ANIMAL young; Subject Term: PREGNANCY in animals; Subject Term: PEERS; Author-Supplied Keyword: kinship; Author-Supplied Keyword: peer interactions .; Author-Supplied Keyword: Rhesus macaque; Author-Supplied Keyword: siblings; Author-Supplied Keyword: social behavior; Number of Pages: 23p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ockene, Judith K.
AU  - Pechacek, Terry F.
AU  - Vogt, Thomas
AU  - Svendsen, Ken
T1  - Does Switching from Cigarettes to Pipes Reduce Tobacco Smoke Exposure?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/11//
VL  - 77
IS  - 11
M3  - Article
SP  - 1412
EP  - 1416
PB  - American Public Health Association
SN  - 00900036
AB  - (For the MRFIT Research Group)  Abstract: Cigarette smoking histories, reported depth of inhalation, number of pipe and cigars (PC) smoked, serum thiocyanate (SCN) and expired air carbon monoxide (CO) levels were examined in PC male smokers enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). Serum SCN levels for all PC smokers were higher than for non-smokers and lower than for current cigarette smokers. Levels were related lo the amount of product smoke. Prior cigarette smokers had higher SCN levels when compared to PC users who had never smoked cigarettes, smoked a larger number of tobacco, products pet' day, and reported inhaling into the chest more often. Prospective data on baseline cigarette smokers demonstrated that smokers who stopped all tobacco products had a greater drop in SCN and CO than those who switched to PC. The findings strongly suggest that cessation of all tobacco products is the best strategy for decreasing exposure to tobacco smoke Am Public Health 1987; 77: 1412-1416.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIGARETTE smokers
KW  - THIOCYANATES
KW  - CARBON monoxide
KW  - SMOKING
KW  - TOBACCO products
KW  - TOBACCO
KW  - ANTISMOKING movement
KW  - TOBACCO industry
KW  - CLINICAL trials
N1  - Accession Number: 4951907; Ockene, Judith K. 1 Pechacek, Terry F. 2 Vogt, Thomas 3 Svendsen, Ken 4; Affiliation:  1: Division of Preventive Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605  2: Director, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda  3: Center for Health Services, Portland, OR 97215  4: Coordinating Centers for Biometric Research, University of Minnesota, Minneapolis; Source Info: Nov87, Vol. 77 Issue 11, p1412; Subject Term: CIGARETTE smokers; Subject Term: THIOCYANATES; Subject Term: CARBON monoxide; Subject Term: SMOKING; Subject Term: TOBACCO products; Subject Term: TOBACCO; Subject Term: ANTISMOKING movement; Subject Term: TOBACCO industry; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - James, S. P.
AU  - Graeff, A.S.
T1  - Effect of IL-2 on immunoregulatory function of intestinal lamina propria T cells in normal non-human primates.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/11//
VL  - 70
IS  - 2
M3  - Article
SP  - 394
EP  - 402
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The role of T cell activation on the immunoregulatory function of lymphocytes in the lamina propria of the normal intestine was investigated. Lymphocytes were isolated from different sites in non-human primates, and their cell surface phenotypes, response to exogenous IL-2, and immunoregulatory function in pokeweed mitogen stimulated cultures were determined. The proportions of Leu-3+ (CD4) and Leu-2+ (CD8) lymphocytes in isolated lamina propria cells were similar to peripheral blood and spleen, but the proportion of Leu-3+ cells was significantly higher in mesenteric lymph node lymphocytes. The proportion of IL-2 receptor positive cells was significantly higher in lamina propria compared with peripheral blood, spleen and mesenteric lymph nodes. Increased IL-2 receptor expression was found on both Leu-3+ and Leu-2+ lamina propria T cells. In addition, although lamina propria T cells had a lower proliferative response to Con A, they had a significantly higher response when cultured with recombinant IL-2, indicating that they have increased expression of functional IL-2 receptors. The helper function of lamina propria T cells for pokeweed mitogen stimulated immunoglobulin synthesis was enhanced by recombinant IL-2. Although Leu-2+ lymphocytes in the lamina propria had increased lL-2 receptor expression, suppressor function of lamina propria T cells was similar to that of spleen cells, and was not enhanced by addition of exogenous IL-2. Thus. T cells in the lamina propria have increased expression of functional IL-2 receptors, and recombinant IL-2 enhances the helper, but not the suppressor function of lamina propria T cells for immunoglobulin synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - CELLS
KW  - T cells
KW  - LEUCOCYTES
KW  - LYMPHOID tissue
KW  - LYMPH nodes
KW  - lamina propria lymphocytes interleukin 2 primate lymphocytes intestinal lymphocytes
N1  - Accession Number: 15993328; James, S. P. 1 Graeff, A.S. 1; Affiliation:  1: Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Nov1987, Vol. 70 Issue 2, p394; Subject Term: LYMPHOCYTES; Subject Term: CELLS; Subject Term: T cells; Subject Term: LEUCOCYTES; Subject Term: LYMPHOID tissue; Subject Term: LYMPH nodes; Author-Supplied Keyword: lamina propria lymphocytes interleukin 2 primate lymphocytes intestinal lymphocytes; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chopra, R. K.
AU  - Nagel, J. E.
AU  - Chrest, F. J.
AU  - Adler, W. H.
T1  - Impaired phorbol ester and calcium ionophore induced proliferation of T cells from old humans.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1987/11//
VL  - 70
IS  - 2
M3  - Article
SP  - 456
EP  - 462
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Current models of T cell activation implicate increases in intracellular free Ca2+ concentration and activation of the Ca2+ and phospholipid dependent enzyme protein kinase C (PKC) as important early events leading to interieukin 2 (IL-2) production, interleukin 2 receptor (IL-2R) expression, and subsequent cell proliferation. The present study examined the age-related defect in T cell proliferation to determine if the signals that activate PKC and increase intracytosolic free Ca2+ concentration might be defective. Using phorbol myristate acetate (PMA), which directly activates PKC, and Ca2+ ionophore A23187, which increases intracellular cytoplasmic free Ca2+ concentration, the induction of IL-2 secretion, IL-2R expression and cell proliferation were studied. The results demonstrate that following stimulation with PMA and A23187, purified T cells from elderly subjects demonstrate low levels of IL-2 production, IL-2R expression and cell proliferation. Exogenous purified human IL-2 did not fully correct the low proliferative responses of T cells from old donors, however, did markedly boost the response. While it appears that the inability of T cells to express IL-2 Rand respond to IL- 2, along with a lower endogenous IL-2 production are limiting factors in cell proliferation, the inability of PMA and A23187 to correct this defect suggests that the early phases of signal transduction per se are probably not a primary cause of the immunodeficiency seen in ageing. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ORGANIC compounds
KW  - LYMPHOCYTES
KW  - CELL division (Biology)
KW  - CELL proliferation
KW  - CELLULAR growth
KW  - PHORBOL esters
KW  - Ca-ionophore phorbol myristale acetate interleukin 2 interleukin 2 receptor
N1  - Accession Number: 15993375; Chopra, R. K. 1 Nagel, J. E. 1 Chrest, F. J. 1 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Ageing, National Institutes of Health, Baltimore, Maryland.; Source Info: Nov1987, Vol. 70 Issue 2, p456; Subject Term: ORGANIC compounds; Subject Term: LYMPHOCYTES; Subject Term: CELL division (Biology); Subject Term: CELL proliferation; Subject Term: CELLULAR growth; Subject Term: PHORBOL esters; Author-Supplied Keyword: Ca-ionophore phorbol myristale acetate interleukin 2 interleukin 2 receptor; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gaither, T. A.
AU  - Vargas, I.
AU  - Inada, S.
AU  - Frank, M. M.
T1  - The complement fragment C3d facilitates phagocytosis by monocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1987/11//
VL  - 62
IS  - 3
M3  - Article
SP  - 405
EP  - 411
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Two receptors for fragments of C3 are described for human monocytes: CR1 and CR3, which bind C3b and iC3b, respectively. Recently a leucocyte receptor that binds C3dg has also been described, designated CR4. We previously reported that IgM-sensitized sheep erythrocytes that are heavily coated with C3d (EAC3d) can bind to human monocytes that have been cultured in fetal calf serum (FCS). Here we determine whether such binding of C3d-coated targets can lead to phagocytosis, and identify the specific monocyte receptor involved in C3d binding. We confirm that EAC3d bearing greater than 10,000 C3d/cell bind to FCS-cultured monocytes. Furthermore, using non-cultured monocytes, we demonstrate that C3d enhances rosette formation of IgG-coated E and, like C3b and iC3b, C3d augments IgG Fc receptor-mediated phagocytosis. Less than 100 C3d/cell are capable of enhancing phagocytosis, whereas 10,000 or more C3d/cell are required for rosette formation with cultured cells. These results indicate that the C3d-binding receptor is present on peripheral blood monocytes but has poor affinity for target particles coated only with C3d. Anti-CR2 monoclonal antibodies, which recognize the C3d receptor of lymphocytes, do not block EAC3d rosette formation with monocytes. In contrast anti-Mol, a monoclonal antibody against CR3, inhibits EAC3d rosettes by approximately 42%. Anti-CR1 increases this effect, but complete inhibition is not achieved. Ethylenediamine tetraacetate also markedly reduces EAC3d rosetting, reducing the numbers to less than 5%. Thus, the C3d-binding receptor on monocytes, unlike CR4, is metal dependent. Together these data indicate that CR3 is predominantly responsible for C3d binding to monocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHAGOCYTOSIS
KW  - MONOCYTES
KW  - LEUCOCYTES
KW  - ERYTHROCYTES
KW  - ACETATES
KW  - ETHYLENEDIAMINE
N1  - Accession Number: 14007982; Gaither, T. A. 1 Vargas, I. 1 Inada, S. 2 Frank, M. M. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases  2: Fugita-Gakuen University, Nagoya, Japan; Source Info: Nov87, Vol. 62 Issue 3, p405; Subject Term: PHAGOCYTOSIS; Subject Term: MONOCYTES; Subject Term: LEUCOCYTES; Subject Term: ERYTHROCYTES; Subject Term: ACETATES; Subject Term: ETHYLENEDIAMINE; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104761988
T1  - Regional cerebral palmitate incorporation following transient bilateral carotid occlusion in awake gerbils.
AU  - Tone, O
AU  - Miller, J C
AU  - Bell, J M
AU  - Rapoport, S I
Y1  - 1987/11//1987 Nov-Dec
N1  - Accession Number: 104761988. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Cerebral Ischemia -- Metabolism
KW  - Rodents -- Metabolism
KW  - Hippocampus -- Metabolism
KW  - Fatty Acids -- Metabolism
KW  - Animals
KW  - Cerebral Ischemia -- Etiology
KW  - Radioisotopes -- Diagnostic Use
KW  - Carotid Arteries -- Physiology
KW  - Cell Physiology
KW  - Cerebrovascular Circulation
KW  - Consciousness
KW  - Immobilization
KW  - Hippocampus -- Pathology
KW  - Lipid Metabolism, Inborn Errors
KW  - Male
KW  - Time Factors
SP  - 1120
EP  - 1127
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 18
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - [14C]Palmitate was injected intravenously in awake gerbils at various times after 5 minutes of bilateral carotid artery occlusion or a sham operation. Regional rates of incorporation of plasma palmitate into the hippocampus and other regions of the anterior circulation were determined relative to the mean rate of incorporation into regions of the posterior circulation using quantitative autoradiography and a ratio method of analysis. One day after bilateral carotid occlusion, relative palmitate incorporation was elevated significantly by 16% in the CA4 pyramidal cell layer and by 20% in the dentate gyrus of the hippocampus compared with sham-operated gerbils. At 3 days, significant elevations of this magnitude were found in the CA3 and CA4 cell layers, whereas relative incorporation was reduced by 26% in the CA1 pyramidal cell layer. At 7 days, the only significant difference from control was a 15% elevated incorporation in the CA3 pyramidal cell layer. Histologic examination indicated substantial cell death in the CA1 pyramidal layer at 3 days, with extensive glial reaction and phagocytic invasion at 7 days. Our results suggest that the turnover of palmitate-containing lipids is reduced in the CA1 layer of the gerbil hippocampus but that lipid synthesis is stimulated in hippocampal regions (CA3, CA4, dentate gyrus) affected by but recovering from transient bilateral carotid occlusion.
SN  - 0039-2499
AD  - Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.
U2  - PMID: 3686587.
DO  - 10.1161/01.STR.18.6.1120
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kimura, Teruyuki
AU  - Owens, Ida S.
T1  - Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1987/11/02/
VL  - 168
IS  - 3
M3  - Article
SP  - 515
EP  - 521
PB  - Wiley-Blackwell
SN  - 00142956
AB  - A cDNA clone (UDPGTm-1) encoding a mouse UDP glucuronosyltransferase (transferase) was isolated from pBR322 and λgt11 libraries by hybridization to a rat transferase clone. This eDNA is 1860 bp long and 65-87% similar at both the nucleotide and the deduced amino acid sequence levels to three different rat transferase clones [Mackenzie, P. I. et al. (1984) J. Biol. Chem. 259, 12153-12160; Mackenzie, P. I. (1986) J. Biol. Chem. 261, 6119-6125]. UDPGTm-1, like the rat transferase clones already described, contains an open reading frame of 1590 bp encoding 530 amino acids (unmodified Mr = 60856), an N-terminus membrane-insertion signal sequence, a carboxy-terminus hydrophobic putative membrane-spanning region, and potential asparagine-linked glycosylation sites (residues 316 and 483). The eDNA contains two poly(A) addition consensus sequences at positions 1695-1837. UDPGTm-1 is complementary to a 2200-base mRNA and also cross-hybridizes to a 2000-base mRNA species due to sequence homology in the 5' region of the clone. Both the 2200-base and the 2000-base mRNA are induced approximately 2.5-fold by the hypolipidemic agent clofibrate, and also by phenobarbital and benzo[a]pyrene. A new and more potent hypolipidemic agent, perfluorooctanoic acid, is also shown to induce both mRNA species. Each of these compounds induces bilirubin transferase activity in a manner parallel to the effects on mRNA, i. e. perfluorooctanoic acid being the most effective, followed by phenobarbital, beazo[a]pyrene, and clofibrate. Southern blot hybridization of UDPGTm-1 to mouse genomic DNA showed sequence homology to a total DNA size of 40-50 kb. These data indicate that UDPGTm-1, is a member of a new subfamily of transferases in mouse with patterns of regulation of their mRNAs similar to that seen for bilirubin transferase activity. [ABSTRACT FROM AUTHOR]
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KW  - GLUCURONOSYLTRANSFERASE
KW  - GLYCOSYLTRANSFERASES
KW  - DNA
KW  - AMINO acid sequence
KW  - MESSENGER RNA
KW  - HOMOLOGY (Biology)
N1  - Accession Number: 13813498; Kimura, Teruyuki 1 Owens, Ida S. 1; Affiliation:  1: Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 11/2/87, Vol. 168 Issue 3, p515; Subject Term: GLUCURONOSYLTRANSFERASE; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: DNA; Subject Term: AMINO acid sequence; Subject Term: MESSENGER RNA; Subject Term: HOMOLOGY (Biology); Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - IWAMOTO, YUKIHIDE
AU  - ROBEY, FRANK A.
AU  - GRAF, JEANNETTE
AU  - SASAKI, MAKOTO
AU  - KLEINMAN, HYNDA K.
AU  - YAMADA, YOSHIHIKO
AU  - MARTIN, GEORGE R.
T1  - YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimenal Metastasis Formation.
JO  - Science
JF  - Science
Y1  - 1987/11/20/
VL  - 238
IS  - 4830
M3  - Article
SP  - 1132
EP  - 1134
SN  - 00368075
AB  - The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachent and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence oflaminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87477684; IWAMOTO, YUKIHIDE 1 ROBEY, FRANK A. 2 GRAF, JEANNETTE 1 SASAKI, MAKOTO 1 KLEINMAN, HYNDA K. 1 YAMADA, YOSHIHIKO 1 MARTIN, GEORGE R. 1; Affiliation:  1: Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, National Institutes of Health, Bethesda, MD 20892  2: Bureau of Biologics, Food and Drug Administration, Bethesda, MD 20892; Source Info: 11/20/1987, Vol. 238 Issue 4830, p1132; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KEHRL, JOHN H.
AU  - ALVAREZ-MON, MELCHOR
AU  - DELSING, GITA A.
AU  - FAUCI, ANTHONY S.
T1  - Lymphotoxin Is an Important T Cell-Derived Growth Factor for Human B Cells.
JO  - Science
JF  - Science
Y1  - 1987/11/20/
VL  - 238
IS  - 4830
M3  - Article
SP  - 1144
EP  - 1146
SN  - 00368075
AB  - Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin hanced the proliferation of activated B cells and augented B cell proliferation and inmunogloblin secretion induced by interleukin-2. [ABSTRACT FROM AUTHOR]
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N1  - Accession Number: 87477688; KEHRL, JOHN H. 1 ALVAREZ-MON, MELCHOR 1 DELSING, GITA A. 1 FAUCI, ANTHONY S. 1; Affiliation:  1: Laboratory of Immunoregulation, National Institute of Allergy and Infetious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 11/20/1987, Vol. 238 Issue 4830, p1144; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mulhern, Sally A.
AU  - Raveche, Elizabeth S.
AU  - Smith, Howard R.
AU  - Lai, Renu B.
T1  - Dietary copper deficiency and autoimmunity in the NZB mouse.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1987/12//
VL  - 46
IS  - 6
M3  - Article
SP  - 1035
EP  - 1039
SN  - 00029165
AB  - NZB mice were exposed from birth to a diet either adequate or deficient in copper. By age 6 wk the mice exposed to the copper-deficient diet showed symptoms characteristic of copper deficiency (anemia, hypoceruloplasminemia, and achromatrichia). The splenic lymphocytes from the copper-deficient group had reduced numbers of cells expressing the following surface markers: Ly-5, Ly-1, B-220, and sIg. Less than 10% of the splenic lymphocytes in this group were cycling, as determined by flow cytometry analysis. The spontaneous 96-h anti-ss-DNA levels in the copper-deficient group were lower than those in the control group. The exogenous colony-forming units (CFUs) were significantly enhanced in the copper-deficient mice. The decreased splenic lymphoid populations, decreased anti-ss-DNA titers, and increased exogenous CFUs in the copper-deficient mice appear to be due to an increase in erythropoiesis at the expense of lymphopoiesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Dietary supplements
KW  - Cytometry
KW  - Autoimmunity
KW  - Autoantibodies
KW  - Lymphoid tissue
KW  - copper deficiency
KW  - immunology
KW  - nutrition
N1  - Accession Number: 91710908; Mulhern, Sally A. 1; Raveche, Elizabeth S. 2; Smith, Howard R. 3; Lai, Renu B. 4; Affiliations: 1: Food and Drug Administration, Washington, DC; 2: Albany Medical College of Union University, Albany, NY; 3: Veterans Administration Hospital, Boston, MA; 4: National Institutes of Health, Bethesda, MD; Issue Info: Dec1987, Vol. 46 Issue 6, p1035; Thesaurus Term: Dietary supplements; Thesaurus Term: Cytometry; Subject Term: Autoimmunity; Subject Term: Autoantibodies; Subject Term: Lymphoid tissue; Author-Supplied Keyword: copper deficiency; Author-Supplied Keyword: immunology; Author-Supplied Keyword: nutrition; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Malloy, Michael H.
AU  - Hartford, Robert B.
AU  - Kleinman, Joel C.
T1  - Trends in Mortality Caused by Respiratory Distress Syndrome in the United States, 1969-83.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/12//
VL  - 77
IS  - 12
M3  - Article
SP  - 1511
EP  - 1514
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Using United States vital statistical data we examined trends in infant deaths from Respiratory Distress Syndrome/Hyaline Membrane Disease (RDS/HMD) for 1969 to 1983, by race and age at death, In order to improve comparability of diagnosis across two revisions of the International Classification of Diseases, deaths from RDS/HMD were ascertained using both underlying and associated causes of death, These data document a 2 per ¢ per year increase in infant mortality attributed to RDS/HMD for all races during interval I (1969-73) tallowed by 9 per ¢ per year decreases during intervals II (1974-78) and III (1979-83), However. there was a marked difference between Whites and Blacks ia these trends. In the White population, RDS/HMD infant mortality increased by 22 per ¢ per year irt interval I but then decreased by 10.5 percent per year in interval II and 8.9 per ¢ per year in interval III. Among Blacks, on the other hand, the initial increase in RDS/HMD mortality was steeper (5.2 per ¢ per year) and the subsequent decreases were less (6.3 per ¢ per year and 8.0 per ¢ pet' year). As a result, the Black-White ratio in infant mortality attributed to RDS/HMD increased from 1.32 in 1969-73, to 1.59 in 1974-78 and to 1.72 in 1979-83. The proportion of RDS/HMD deaths that occurred in the postneonatal period increased from I. I percent in interval 1 to 3.6 per ¢ in interval II to 5.0 per ¢ in interval III. During the last interval, the decline in RDS/HMD mortality accounted for 30 per ¢ of the decline in overall infant mortality for both Whites and Blacks. (Am J Public Health 1987: 77:1511-1514.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INFANTS -- Death
KW  - DEATH -- Causes
KW  - PEDIATRIC respiratory diseases
KW  - RESPIRATORY distress syndrome
KW  - PULMONARY manifestations of general diseases
KW  - HYALINE membrane disease
KW  - MORTALITY -- Statistics
KW  - PUBLIC health -- United States
KW  - UNITED States
N1  - Accession Number: 4949568; Malloy, Michael H. 1 Hartford, Robert B. 2 Kleinman, Joel C. 3; Affiliation:  1: Prevention Research Program, National Institute of Child Health and Human Development, Landow Building, Room 8A06, 7910 Woodmount Avenue, Bethesda, MD 20892  2: Deputy Chief, International Statistics Staff, Office of Planning and Extramural Programs, National Center for Health Statistics  3: Director, Division of Analysis, Office of Analysis and Epidemiology Program, NCHS; Source Info: Dec1987, Vol. 77 Issue 12, p1511; Subject Term: INFANTS -- Death; Subject Term: DEATH -- Causes; Subject Term: PEDIATRIC respiratory diseases; Subject Term: RESPIRATORY distress syndrome; Subject Term: PULMONARY manifestations of general diseases; Subject Term: HYALINE membrane disease; Subject Term: MORTALITY -- Statistics; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McWhorter, William P.
AU  - Mayer, William J.
T1  - Black/White Differences in Type of Initial Breast Cancer Treatment and Implications for Survival.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/12//
VL  - 77
IS  - 12
M3  - Article
SP  - 1515
EP  - 1517
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The relation between race, type of initial treatment, and survival with breast cancer were investigated using 36,905 cases reported to nine registries in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute in the years 1978-82 and followed for survival through 1984. Using the crude treatment categories of surgical/nonsurgical/untreated, Blacks were found lo have received less aggressive therapy. They were more likely than Whites to be treated nonsurgicalty (OR = 1.4: 95% CI = 1.2-1.7) or have no cancer-directed therapy (OR = 1.7; 95% CI = 1.3-2.3). even after adjusting by logistic regression for differences in age, stage, and histology. These treatment variables strongly affected five-year survival, after adjusting for age, singe, race, and histology. This finding of racial differences in survival-associated treatment patterns demonstrates thc need to consider treatment variables in studies of race and cancer survival. (Am J Public Health 1987: 77:1515-1517.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISCRIMINATION in medical care
KW  - CANCER treatment
KW  - CANCER patients -- Social conditions
KW  - AFRICAN Americans
KW  - WHITES
KW  - BREAST cancer
KW  - SURVIVAL behavior (Animals)
KW  - CANCER -- Mortality
KW  - PUBLIC health
KW  - HUMAN services
N1  - Accession Number: 4949570; McWhorter, William P. 1 Mayer, William J. 1; Affiliation:  1: Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Dec1987, Vol. 77 Issue 12, p1515; Subject Term: DISCRIMINATION in medical care; Subject Term: CANCER treatment; Subject Term: CANCER patients -- Social conditions; Subject Term: AFRICAN Americans; Subject Term: WHITES; Subject Term: BREAST cancer; Subject Term: SURVIVAL behavior (Animals); Subject Term: CANCER -- Mortality; Subject Term: PUBLIC health; Subject Term: HUMAN services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kovar, Mary Grace
AU  - Harris, Maureen I.
AU  - Hadden, Wilbur C.
T1  - The Scope of Diabetes in the United States Population.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1987/12//
VL  - 77
IS  - 12
M3  - Article
SP  - 1549
EP  - 1550
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the national study entitled "Second National Health and Nutrition Examination Survey (NHANES II)," that was conducted by the U.S. National Center for Health Statistics from 1976-1980, which investigates the prevalence of diabetes in the population. This is the first national study wherein criteria of the World Health Organization and the National Diabetes Data Group have been used for administering the oral glucose tolerance tests and for classifying diabetes and glucose intolerance. The critical finding from NHANES II is that only about half of people with diabetes know that they are diabetic.
KW  - HEALTH surveys -- United States
KW  - DIABETES -- Research
KW  - DIABETES -- Diagnosis
KW  - DIABETICS
KW  - CARBOHYDRATE intolerance
KW  - PUBLIC health research
KW  - PUBLIC health -- United States
KW  - UNITED States
KW  - NATIONAL Center for Health Statistics (U.S.)
N1  - Accession Number: 4949599; Kovar, Mary Grace 1 Harris, Maureen I. 2 Hadden, Wilbur C. 3; Affiliation:  1: Office of Vital and Health Statistics Systems, NCHS  2: National Diabetes Data Group, National Institute of Diabetes and Digestive & Kidney Diseases, National Institutes of Health  3: Division of Health Examination Statistics, National Center for Health Statistics, 3700 East-West Highway, Room 2-58, Hyattsville, MD 20782; Source Info: Dec1987, Vol. 77 Issue 12, p1549; Subject Term: HEALTH surveys -- United States; Subject Term: DIABETES -- Research; Subject Term: DIABETES -- Diagnosis; Subject Term: DIABETICS; Subject Term: CARBOHYDRATE intolerance; Subject Term: PUBLIC health research; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Friedman, David I.
AU  - Imperiale, Michael J.
AU  - Adhya, Sankar L.
T1  - RNA 3' END FORMATION IN THE CONTROL OF GENE EXPRESSION.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1987/12//
VL  - 21
M3  - Article
SP  - 453
EP  - 488
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Discusses the terminator signals, the role of elongation and termination in regulation of expression, mechanisms of transcription elongation and termination in prokaryotes and similar mechanisms in eukaryotes.  Types of terminator signals; Mechanism of termination at type I terminators; Importance of regulation of gene expression alternative 3' end formation and termination.
KW  - GENE expression
KW  - RNA
KW  - TRANSCRIPTION factors
KW  - PROKARYOTES
KW  - GENETICS
KW  - EUKARYOTIC cells
N1  - Accession Number: 12409440; Friedman, David I. 1 Imperiale, Michael J. 1 Adhya, Sankar L. 2; Affiliation:  1: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109-0620  2: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892; Source Info: 1987, Vol. 21, p453; Subject Term: GENE expression; Subject Term: RNA; Subject Term: TRANSCRIPTION factors; Subject Term: PROKARYOTES; Subject Term: GENETICS; Subject Term: EUKARYOTIC cells; Number of Pages: 36p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104756551
T1  - Testicular cancer in young men: the search for causes of the epidemic increase in the United States.
AU  - Brown, L M
AU  - Pottern, L M
AU  - Hoover, R N
Y1  - 1987/12//
N1  - Accession Number: 104756551. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 7909766. 
KW  - Testicular Neoplasms -- Etiology
KW  - Adolescence
KW  - Adult
KW  - Clothing -- Adverse Effects
KW  - Cryptorchidism -- Complications
KW  - District of Columbia
KW  - Male
KW  - Maryland
KW  - Risk Factors
KW  - Smoking
KW  - Testicular Neoplasms -- Epidemiology
KW  - Testicular Neoplasms -- Pathology
KW  - Testis -- Injuries
KW  - Testis -- Pathology
SP  - 349
EP  - 354
JO  - Journal of Epidemiology & Community Health
JF  - Journal of Epidemiology & Community Health
JA  - J EPIDEMIOL COMMUNITY HEALTH
VL  - 41
IS  - 4
PB  - BMJ Publishing Group
AB  - A case-control study of 271 men with testicular cancer and 259 controls was conducted in the Washington, DC area to evaluate whether suggested risk factors could be responsible for the epidemic increases in testicular cancer in young men. No substantial risks were associated with a history of groin hernia operation, the common childhood diseases, allergies, x rays below the waist, venereal disease, vasectomy, or external means of elevating the temperature of the testis. Excess risks were associated with a history of undescended testis (RR = 3.7, CI = 1.5-9.5), testicular trauma (RR = 2.6, CI = 1.6-4.2), and mumps orchitis (RR = 5.8, CI = 0.7-129.7). It is unlikely, however, that any of these conditions has increased sufficiently over time to markedly affect the testicular cancer incidence patterns. Therefore, while the risk factors identified in this paper are of epidemiological interest, they do not account for the increase in testicular cancer in young men.
SN  - 0143-005X
AD  - Epidemiology and Biostatics Program, National Cancer Institute, Bethesda, MD 20892.
U2  - PMID: 2901454.
DO  - 10.1136/jech.41.4.349
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ER  - 

TY  - JOUR
AU  - Caughman, S. Wright
AU  - Krieg, Thomas
AU  - Timpl, Rupert
AU  - Hintner, Helmut
AU  - Katz, Stephen I.
T1  - Nidogen and Heparan Sulfate Proteoglycan: Detection of Newly Isolated Basement Membrane Components in Normal and Epidermolysis Bullosa Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1987/12//
VL  - 89
IS  - 6
M3  - Article
SP  - 547
EP  - 550
SN  - 0022202X
AB  - The epidermal basement membrane zone comprises various biochemical constituents, some of which may be affected or involved in certain forms of mechanobullous diseases. Recently, nidogen and a low density form of heparan sulfate proteoglycan--two ubiquitous, noncollagenous components of basement membranes--were isolated and characterized, and affinity-purified antibodies to each component were prepared. These antibodies were used to study the distribution of both antigens in normal and diseased human skin. By immunofluorescence, both nidogen and heparan sulfate proteoglycan were linearly distributed along the basement membrane of the dermal-epidermal junction, adnexal structures, and blood vessels of normal human skin. On suction-induced blisters of normal skin, both antigens were found at the base of the blister, indicating that each was within or below the lamina lucida. By indirect immunoelectron microscopy, both antigens were ultrastructurally located within the lamina densa. The staining patterns for nidogen and heparan sulfate proteoglycan were examined in 11 patients with either junctional, dominant dystrophic, or recessive dystrophic epidermolysis bullosa, and were found to be not different from the patterns observed in normal skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEOGLYCANS
KW  - GLYCOPROTEINS
KW  - BIOLOGICAL interfaces
KW  - EPIDERMOLYSIS bullosa
KW  - EPITHELIUM
KW  - BIOLOGICAL membranes
N1  - Accession Number: 12461192; Caughman, S. Wright 1 Krieg, Thomas 2 Timpl, Rupert 3 Hintner, Helmut 4 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Dermatologische Klinik und Poliklinik der Ludwig-Maximilians-Universitat, Munchen, F.R.G.  3: Max-Planck Institut fur Biochemie, Martinsried, F.R.G.  4: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.; Source Info: Dec87, Vol. 89 Issue 6, p547; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; Subject Term: BIOLOGICAL interfaces; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: EPITHELIUM; Subject Term: BIOLOGICAL membranes; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12461192
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DB  - aph
ER  - 

TY  - JOUR
AU  - Wittes, Janet
AU  - Wallenstein, Sylvan
T1  - The Power of the Mantel-Haenszel Test.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1987/12//
VL  - 82
IS  - 400
M3  - Article
SP  - 1104
SN  - 01621459
AB  - The Mantel-Haenszel (MH) test (Mantel and Haenszel 1959) is a widely used method for analyzing sets of two-by-two tables that compare the outcome of two treatments in several strata (Bailar and Anthony 1977). The procedure tests the null hypothesis of no partial association between treatment and outcome in any of the strata, or tables, against the alternative that the partial association, as measured by the common odds ratio, differs from 1. Birch (1964) showed that for a fixed number of tables, both the MH test and an earlier version due to Cochran (1954) are asymptotically identical to the uniformly most powerful unbiased test of this hypothesis.  This article is concerned with calculating the power of the MH test as a prelude to embarking upon a study. We consider versions of the test with and without corrections for continuity. The spirit behind the approximations is that, although the odds ratio is the appropriate parameter for computing asymptotic power under local alternatives, in practice studies are designed for nonlocal alternatives. Our approach is based on evaluating a weighted difference of proportions of success in each table, rather than a weighted average of log-odds ratios, and is valid even if the odds ratios differ from table to table. The adequacy of our approximations to power is evaluated for planning three types of studies: the comparative binomial (CB), the double dichotomy (DD), and the survey (SY). In the CB trial, the proportion lambda[sub l] of patients in the ith strata, as well as the proportion rho[sub l] of patients in the ith strata who are assigned to the first treatment, are constants (I = 1, 2, ..., N). For the DD only the rho[sub l]'s are constant, whereas for the SY both vectors are random variables.  We first approximate power under the condition that for each stratum NE(lambda[sub l]) is large. This approximation cannot distinguish between corrected and uncorrected statistics nor among the different sampling schemes. In some [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICAL hypothesis testing
KW  - APPROXIMATION theory
KW  - SAMPLING (Statistics)
KW  - MATHEMATICAL statistics
KW  - MULTIVARIATE analysis
KW  - VARIABLES (Mathematics)
KW  - BINOMIAL distribution
KW  - SAMPLE size (Statistics)
KW  - Conditional test.
KW  - Partial associations
KW  - Poststratification
KW  - Sample size
N1  - Accession Number: 4610405; Wittes, Janet 1; Wallenstein, Sylvan 2; Affiliations: 1: Chief of the Biostatistics Research Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.; 2: Associate Professor of Clinical Public Health, Division of Biostatistics, Columbia University School of Public Health, New York, NY 10032.; Issue Info: Dec87, Vol. 82 Issue 400, p1104; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: MULTIVARIATE analysis; Subject Term: VARIABLES (Mathematics); Subject Term: BINOMIAL distribution; Subject Term: SAMPLE size (Statistics); Author-Supplied Keyword: Conditional test.; Author-Supplied Keyword: Partial associations; Author-Supplied Keyword: Poststratification; Author-Supplied Keyword: Sample size; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 6p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Roberts, Bruce R.
T1  - A Confirmatory Factor-Analytic Model of Alienation.
JO  - Social Psychology Quarterly
JF  - Social Psychology Quarterly
Y1  - 1987/12//
VL  - 50
IS  - 4
M3  - Article
SP  - 346
EP  - 351
SN  - 01902725
AB  - This paper presents a longitudinal second-order confirmatory factor-analytic model of alienation in employed U.S. men, based on Seeman's original five-facet conceptualization. Alienation appears in this model as a second -order factor that is significantly related to all five of these facets. Powerlessness and self-estrangement are shown to be the two central facets. Meaninglessness, normlessness and cultural estrangement show progressively smaller relationships to the underlying alienation construct. Although cultural estrangement is significantly related to the underlying construct, removing it results in a model that fits the data slightly better, Cross-national comparisons using cross-sectional data from Poland and Japan confirm the generalizability of this model. However, the magnitudes of the relationships of both normlessness and cultural estrangement to the second-order factor are somewhat different for Japan than for the United States and Poland. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Psychology Quarterly is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALIENATION (Social psychology)
KW  - SOCIAL psychology
KW  - DEPERSONALIZATION
KW  - SOCIAL isolation
KW  - FACTOR analysis
KW  - FACTOR structure
N1  - Accession Number: 13571329; Roberts, Bruce R. 1; Affiliation:  1: National institute of Mental Health.; Source Info: Dec87, Vol. 50 Issue 4, p346; Subject Term: ALIENATION (Social psychology); Subject Term: SOCIAL psychology; Subject Term: DEPERSONALIZATION; Subject Term: SOCIAL isolation; Subject Term: FACTOR analysis; Subject Term: FACTOR structure; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
ID  - 119722332
T1  - Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene "anti-sense" transcript by in situ hybridization.
AU  - Croen, K D
AU  - Ostrove, J M
AU  - Dragovic, L J
AU  - Smialek, J E
AU  - Straus, S E
Y1  - 1987/12/03/
N1  - Accession Number: 119722332. Language: English. Entry Date: 20161118. Revision Date: 20161127. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Sensory Integration and Praxis Tests (SIPT) (Ayres). NLM UID: 0255562. 
KW  - Proteins
KW  - Genes
KW  - RNA
KW  - Herpes Simplex -- Microbiology
KW  - Herpesviruses
KW  - Trigeminal Nerve -- Microbiology
KW  - Ganglia, Sensory -- Microbiology
KW  - Middle Age
KW  - Herpesviruses -- Immunology
KW  - Adult
KW  - Enzymes
KW  - Aged
KW  - Child
KW  - Nucleic Acid Hybridization
KW  - Adolescence
KW  - RNA -- Analysis
KW  - Antibodies, Viral -- Analysis
SP  - 1427
EP  - 1432
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 317
IS  - 23
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - We used in situ hybridization to study the expression of herpes simplex virus type 1 genes during latent infections of human sensory ganglia. Trigeminal ganglia were recovered at autopsy from 24 subjects with no evidence of an active herpetic infection. These ganglia were hybridized to 35S-labeled single-stranded RNA probes spanning 72 percent of the herpes simplex genome. In the ganglia of 16 subjects, 0.2 to 4.3 percent of the neuronal cells contained abundant nuclear signals for viral RNA. Ganglia from three patients with low or undetectable levels of antibodies to herpes simplex type 1 lacked viral RNA signals, whereas the ganglia from all of six patients with elevated antibody titers showed viral RNA signals. Transcription was detected only from the region of the viral genome containing a gene that encodes an immediate early protein known as the infected-cell protein number zero (ICP0). However, normal ("sense") transcripts of this gene, which are prominent in an acute infection, were not detected. In contrast, a novel transcript was found overlapping with, but opposite in direction to, the ICP0 transcript (and was therefore "anti-sense"). Although this transcript has been only partially characterized, we believe that it may have a role in maintaining the latency of herpes simplex virus.
SN  - 0028-4793
AD  - Medical Virology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Md
U2  - PMID: 2825014.
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ER  - 

TY  - JOUR
AU  - VELU, THIERRY J.
AU  - BEGUINOT, LAURA
AU  - VASS, WILLIAM C.
AU  - WILLINGHAM, MARK C.
AU  - MERLINO, GLENN T.
AU  - PASTAN, IRA
AU  - LOWY, DOUGLAS R.
T1  - Epidermal Growth Factor-Dependent Transfortion by a Human EGF Receptor Proto-Oncogene.
JO  - Science
JF  - Science
Y1  - 1987/12/04/
VL  - 238
IS  - 4832
M3  - Article
SP  - 1408
EP  - 1410
SN  - 00368075
AB  - The epidernal growth factor (EGF) receptor gene EGFR has been placed in a retrovirus vector to examine the growth properties of cells that experimentally overproduce a full-length EGF receptor. NIH 3T3 cells transfected with the viral DNA or infected with the corresponding rescued retrovirus developed a fully transformed phenotype in vitro that required both functional EGFR expression and the presence of EGF in the growth medium. Cells expressing 4 × 103 EGF receptors formed tumors in nude mice, while control cells did not. Therefore, the EGFR retrovirus, which had a titer on NIH 3T3 cells that was greater than 107 focus-forming units per milliliter, can efficiently transfer and express this gene, and increased numbers of EGF receptors can contribute to the transformed phenotype. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 84692567; VELU, THIERRY J. 1 BEGUINOT, LAURA 2 VASS, WILLIAM C. 1 WILLINGHAM, MARK C. 2 MERLINO, GLENN T. 2 PASTAN, IRA 2 LOWY, DOUGLAS R. 1; Affiliation:  1: Laboratory of Ccllular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892  2: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 12/ 4/1987, Vol. 238 Issue 4832, p1408; Number of Pages: 3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Bender, B. S.
AU  - Winchurch, R. A.
AU  - Thupari, J. N.
AU  - Proust, J. J.
AU  - Adler, W. H.
AU  - Munster, A. M.
T1  - Depressed natural killer cell function in thermally injured adults: successful in vivo and in vitro immunomodulation and the role of endotoxin.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1988/01//
VL  - 71
IS  - 1
M3  - Article
SP  - 120
EP  - 125
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in burn patients using a 51Cr release assay with K562 target cells. We found that peripheral blood lymphocytes from burn patients had depressed NK activity (target cell lysis = 22.0 ± 3.1% vs 39.8 ± 3.2% in healthy volunteers, P < 0.001) and also a lower response to IL-2 (28.9 ± 3.8% vs 53.2 ± 4.3%, P < 0.001). Thirteen burn patients were randomly assigned lo receive either standard therapy or 5 days of intravenous polymyxin B in addition fo standard therapy. After 2 weeks, the patients not receiving polymyxin B had a significant decline in peripheral blood NK activity (P < 0.01) and response to IL-2 (P < 0.05), white no decline in NK cell activity was seen in patients who received polymyxin B. Sera from burn patients was found to suppress the NK activity of lymphocytes from healthy adults by 5-75%. After using affinity chromatography to remove endotoxin, the sera from burn patients no longer suppressed NK cell activity. Circulating endotoxin appears to be involved in the suppression of NK activity in burn patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KILLER cells
KW  - INTERLEUKIN-2
KW  - ENDOTOXINS
KW  - IMMUNE response -- Regulation
KW  - LYMPHOCYTES
KW  - POLYMYXIN
KW  - burn
KW  - endotoxin
KW  - IL-2
KW  - NK cells
KW  - polymyxin B
N1  - Accession Number: 16201686; Bender, B. S. 1,2 Winchurch, R. A. 1,2 Thupari, J. N. 1,2 Proust, J. J. 1,2 Adler, W. H. 1,2 Munster, A. M. 1,2; Affiliation:  1: Clinical Immunology Section, National Institute on Aging, NIH, Baltimore, USA.  2: Baltimore, Regional Burn Center, Department of Surgery, Francis Scott Key Medical Center, A  Johns Hopkins Medical Institution, Baltimore, USA.; Source Info: Jan1988, Vol. 71 Issue 1, p120; Subject Term: KILLER cells; Subject Term: INTERLEUKIN-2; Subject Term: ENDOTOXINS; Subject Term: IMMUNE response -- Regulation; Subject Term: LYMPHOCYTES; Subject Term: POLYMYXIN; Author-Supplied Keyword: burn; Author-Supplied Keyword: endotoxin; Author-Supplied Keyword: IL-2; Author-Supplied Keyword: NK cells; Author-Supplied Keyword: polymyxin B; Number of Pages: 6p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Burns, Barbara J.
AU  - Larson, David B.
AU  - Goldstrom, Ingrid D.
AU  - Johnson, Wayne E.
AU  - Taube, Carl A.
AU  - Miller, Nancy E.
AU  - Mathis, Evelyn s.
T1  - MENTAL DISORDER AMONG NURSING HOME PATIENTS: PRELIMINARY FINDINGS FROM THE NATIONAL NURSING HOME SURVEY PRETEST.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1988/01//Jan-Mar1988
VL  - 3
IS  - 1
M3  - Article
SP  - 27
EP  - 35
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - Ninety-six per cent of mentally ill elderly persons who are not in the community reside in nursing homes, yet the mental health care they receive there is minimal or unavailable. Data are presented from the 1984 pretest of the National Nursing Home Survey. Five hundred and twenty-six patients in 112 nursing homes in four US metropolitan areas were sampled. Overall, the prevalence of mental disorder was found to be 68%; 39% of the patients had a diagnosis of organic brain syndrome (OBS) and 29% had other mental disorders (OMD). Only about one-third (31%) or residents had no mental disorder. These three patient groups, those with OBS, those with OMD, and those with no mental disorder, were compared on demographic, clinical, and treatment characteristics. The authors conclude that the balance between the Federal and State roles in financing care for the mentally ill in nursing homes needs to result in a more equitable system of care which does not discriminate against the mentally ill. Further, the mental health service system needs to assume greater responsibility for this populations. While significant attention is given to residents physical needs, behavioural and emotional problems are seriously neglected. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL health
KW  - MENTAL illness
KW  - NURSING home patients
KW  - NEUROBEHAVIORAL disorders
KW  - GERIATRICS
KW  - MENTAL health services
KW  - elderly
KW  - geriatrics.
KW  - Nursing homes
KW  - prevalence
N1  - Accession Number: 12181496; Burns, Barbara J. 1 Larson, David B. 2 Goldstrom, Ingrid D. 2 Johnson, Wayne E. 2 Taube, Carl A. 2 Miller, Nancy E. 2 Mathis, Evelyn s. 3; Affiliation:  1: Department of Psychiatry, University of Maryland Medical School, 645 W. Redwood St. Baltimore, Maryland, 21201 USA.  2: National Institute of Mental Health.  3: National Center for Health Statistics.; Source Info: Jan-Mar1988, Vol. 3 Issue 1, p27; Subject Term: MENTAL health; Subject Term: MENTAL illness; Subject Term: NURSING home patients; Subject Term: NEUROBEHAVIORAL disorders; Subject Term: GERIATRICS; Subject Term: MENTAL health services; Author-Supplied Keyword: elderly; Author-Supplied Keyword: geriatrics.; Author-Supplied Keyword: Nursing homes; Author-Supplied Keyword: prevalence; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 9p; Document Type: Article
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ER  - 

TY  - JOUR
ID  - 104758911
T1  - Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure.
AU  - Bielory, L
AU  - Gascon, P
AU  - Lawley, T J
AU  - Young, N S
AU  - Frank, M M
Y1  - 1988/01//1988 Jan
N1  - Accession Number: 104758911. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Anemia, Aplastic -- Therapy
KW  - Antilymphocyte Serum -- Therapeutic Use
KW  - Bone Marrow -- Physiopathology
KW  - Serum Sickness -- Complications
KW  - T Lymphocytes -- Immunology
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Anemia, Aplastic -- Etiology
KW  - Antigens -- Analysis
KW  - Antilymphocyte Serum -- Adverse Effects
KW  - Child
KW  - Female
KW  - Hematopoiesis
KW  - Human
KW  - Immunoglobulins -- Analysis
KW  - Male
KW  - Middle Age
KW  - Prospective Studies
KW  - Random Assignment
KW  - Serum Sickness -- Immunology
KW  - Serum Sickness -- Physiopathology
KW  - Clinical Trials
SP  - 40
EP  - 57
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 67
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - We have prospectively evaluated the clinical and immunological features of serum sickness in 35 patients treated for bone marrow failure with anti-thymocyte globulin (ATG 15 mg/kg/day) and methylprednisolone (1 to 1.5 mg/kg/day). Twenty-one patients were treated for 10 days and 14 were treated for 28 days. Clinical evidence of serum sickness developed in 30 patients (86%) and included fever and malaise (100%), cutaneous eruptions (93%), arthralgias (67%), gastrointestinal complaints (67%), cephalgia (57%), blurring of vision (37%), arthritis, (30%) and lymphadenopathy (13%). Clinical serum sickness began on day 7 +/- 1 (X +/- S.E.M.) and lasted for 10 +/- 2 days in the 18 affected patients receiving the shorter course of ATG. In the 12 affected patients receiving the longer course of ATG, serum sickness began on day 9 +/- 1. The earliest manifestations of serum sickness were fever, malaise, and cutaneous eruptions. Cutaneous findings consisted of morbilliform eruptions (n = 19) and urticaria (n = 1) or a combination (n = 8) that lasted 10 to 14 days. Twenty-one patients (75%) developed a highly characteristic serpiginous band of erythema and purpura along the sides of the fingers, toes, palms and soles 12 to 48 hours before other symptoms of serum sickness. Biopsies of lesional skin during the course of serum sickness revealed immune deposits (IgM, IgE, IgA and C3) in dermal vasculature in 7 of 9 patients. Immunological changes that occurred during the course of serum sickness included increased serum levels of IgG, IgM, IgA, and IgE. Circulating immune complexes, as measured by the C1q-binding assay, increased from a mean value of 12% to 45% on day 13 +/- 1. Complement levels (C3, C4, and CH50) decreased 50 to 80% from their baseline levels on day 10 +/- 2. Acute phase reactants increased: erythrocyte sedimentation rate, C-reactive protein and beta-2 microglobulin. Abnormal urinalysis developed in 17 patients (57%) over the course of serum sickness and included proteinuria, hematuria and hemoglobinuria on day 10 +/- 3. Hematopoietic response occurred in 43%. All 5 patients who did not develop serum sickness recovered from bone marrow failure. Our data document the clinical and immunopathological findings in human serum sickness and suggest that the principles of antigen-antibody interaction, complement activation, and resultant inflammatory response as seen in the previous animal studies are directly applicable to studies of patients with serum sickness.
SN  - 0025-7974
AD  - Clinical Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland.
U2  - PMID: 3257288.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104758911&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2008-08920-001
AN  - 2008-08920-001
AU  - Lenfant, Claude M.
T1  - Preface.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1988///
VL  - 7
IS  - Suppl
SP  - 1
EP  - 2
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-08920-001. Partial author list: First Author & Affiliation: Lenfant, Claude M.; National Heart, Lung, and Blood Institute, Bethesda, MD, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20100104. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hypertension; Scientific Communication. Classification: Cardiovascular Disorders (3295). Population: Human (10). Location: US. Page Count: 2. Issue Publication Date: 1988. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1988. 
AB  - Reports on the Fifth Joint USA-USSR Symposium on Arterial Hypertension, which was held in Easton, Maryland on March 23-24, 1987. The scientific contributions contained in this Health Psychology supplement are the proceedings from this symposium. The symposium was sponsored by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health as part of the USA-USSR research collaboration in arterial hypertension. This joint effort is conducted under a bilateral agreement between the governments of the United States and the Soviet Union in a variety of cardiovascular research fields. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - arterial hypertension
KW  - USA-USSR Symposium
KW  - 1988
KW  - Hypertension
KW  - Scientific Communication
KW  - 1988
DO  - 10.1037/h0090268
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08920-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-003
AN  - 2005-26897-003
AU  - Goodwin, Frederick K.
T1  - Foreword.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 141
EP  - 143
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Goodwin, Frederick K., Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-003. Partial author list: First Author & Affiliation: Goodwin, Frederick K.; Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Cerebral Blood Flow; Mental Health; Neurosciences; Schizophrenia. Minor Descriptor: At Risk Populations; Tomography. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 3. Issue Publication Date: 1988. 
AB  - The article introduces the papers included in the present issue of Schizophrenia Bulletin. As the world's largest mental health and neuroscience research center, the Intramural Research Program (IRP) of the National Institute of Mental Health (NIMH) has played a major role in many of the scientific advances that are now beginning to unravel the mystery of schizophrenia. We owe much of this progress to certain unique strengths of the IRP research environment. IRP science has contributed to the development of metabolic brain imaging, which has opened new windows into the functional neuroanatomy of schizophrenia. In the late 1940's and early 1950's, Dr. Seymour Kety, IRP's first Scientific Director, conceived the idea of using inert diffusible tracers to study cerebral blood flow, developing the theory and equations which made this possible. A more recent IRP conceptual development derives from Dr. Robert Post's studies of kindling in animals and its possible relationship to mood disorders, particularly rapid-cycling bipolar mood disorder. Carbamazepine, an antikindling drug, was then found to be effective in treating rapidly cycling patients, most of whom are resistant to lithium. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - mental health
KW  - neuroscience research
KW  - cerebral blood flow
KW  - mood disorders
KW  - 1988
KW  - Bipolar Disorder
KW  - Cerebral Blood Flow
KW  - Mental Health
KW  - Neurosciences
KW  - Schizophrenia
KW  - At Risk Populations
KW  - Tomography
KW  - 1988
DO  - 10.1093/schbul/14.2.141
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-005
AN  - 2005-26897-005
AU  - Mirsky, Allan F.
T1  - Research on Schizophrenia in the NIMH Laboratory of Psychology and Psychopathology, 1954-1987.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 151
EP  - 156
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Mirsky, Allan F., Laboratory of Psychology and Psychopathology, NIMH, NIH, Bldg. 10, Rm. 4C110, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-005. PMID: 3059464 Partial author list: First Author & Affiliation: Mirsky, Allan F.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Autonomic Nervous System; Evoked Potentials; Psychopathology; Schizophrenia. Minor Descriptor: Etiology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1988. 
AB  - Since its creation in 1954 (as the Laboratory of Psychology) through the present time, the Laboratory of Psychology and Psychopathology has devoted a major effort to the study of schizophrenia. Shakow's studies on impaired reaction time performance led to the development of the concept of segmental set; Rosenthal's work on genetic factors in the etiology of schizophrenia, as well as on the interaction of stress and diathesis, helped to illuminate the nature of transmission of schizophrenia. These investigations set standards of excellence for careful analysis of psychopathological behavior. Our present program of research on schizophrenia emphasizes autonomic, psychophysiological and event-related brain potential investigations of schizophrenic patients and long-term followup of a high-risk population in Israel. In this group, poor attention in children at genetic risk has proved to be a predictor of later development of a schizophrenia spectrum disorder. Our work also emphasizes a theoretical analysis of the neuropsychological elements that make up attention in relation to psychopathological states. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - psychopathological behavior
KW  - autonomic system
KW  - event related brain potential
KW  - at risk population
KW  - 1988
KW  - At Risk Populations
KW  - Autonomic Nervous System
KW  - Evoked Potentials
KW  - Psychopathology
KW  - Schizophrenia
KW  - Etiology
KW  - 1988
DO  - 10.1093/schbul/14.2.151
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-007
AN  - 2005-26897-007
AU  - Cohen, Robert M.
AU  - Semple, William E.
AU  - Gross, Michael
AU  - Nordahl, Thomas E.
T1  - From Syndrome to Illness: Delineating the Pathophysiology of Schizophrenia With PET.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 169
EP  - 176
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Cohen, Robert M., Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, NIMH, NIH, Bldg. 10, 4N317, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-007. PMID: 3059466 Partial author list: First Author & Affiliation: Cohen, Robert M.; Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neurochemistry; Prefrontal Cortex; Schizophrenia; Syndromes; Tomography. Minor Descriptor: Auditory Discrimination; Pathophysiology; Sustained Attention. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: 1988. 
AB  - The Section on Clinical Brain Imaging of the Laboratory of Cerebral Metabolism has been engaged in studying regional brain metabolism by positron emission tomography (PET) to establish the pathophysiology of schizophrenia. Recent studies have revealed that the fluorodeoxyglucose (FDG) PET methodology can be applied successfully to determine the anatomical substrata of directed attention. In normal controls, the metabolic rate in the middle prefrontal cortex, measured during the ongoing performance of auditory discrimination, is associated with their accuracy of performance. In unmedicated patients with schizophrenia, even those who performed as well as normals, the metabolic rate in the mid-prefrontal cortex was found to be significantly lower than normal. Further, this decreased metabolic rate was unrelated to performance. In medicated patients with schizophrenia, at least part of the metabolic deficit remains, but this deficit appears to be performance-related. These findings suggest several conclusions. The mid-prefrontal cortex and its dopamine neurotransmitter pathway input are important biological determinants of sustained attention. Two types of prefrontal metabolic deficits may contribute to dysfunctional goal-directed behavior and, more speculatively, vulnerability to psychosis in some patients with schizophrenia. One deficit is sensitive to neuroleptics, and thus presumably to a change in the balance of regional brain dopamine input. A second deficit is unaffected by neurolpetic treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain metabolism
KW  - prefrontal cortex
KW  - pathophysiology
KW  - schizophrenia
KW  - positron emission tomography
KW  - sustained attention
KW  - auditory discrimination
KW  - 1988
KW  - Neurochemistry
KW  - Prefrontal Cortex
KW  - Schizophrenia
KW  - Syndromes
KW  - Tomography
KW  - Auditory Discrimination
KW  - Pathophysiology
KW  - Sustained Attention
KW  - 1988
DO  - 10.1093/schbul/14.2.169
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-011
AN  - 2005-26897-011
AU  - Duncan, Connie C.
T1  - Event-Related Brain Potentials: A Window on Information Processing in Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 199
EP  - 203
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Duncan, Connie C., Unit on Psychophysiology, Laboratory of Psychology and Psychopathology, NIMH, Bldg. 10, Rm. 4C110, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-011. PMID: 2904693 Partial author list: First Author & Affiliation: Duncan, Connie C.; Unit on Psychophysiology, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Evoked Potentials; Schizophrenia. Minor Descriptor: Brain. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: 1988. 
AB  - The application of the P300 component of the event-related brain potential to the study of attentional impairment in schizophrenia is discussed, and two recent studies are described. In one, the relative effects on P300 of stimulus modality and probability were evaluated. The data showed that the P300 is smaller in schizophrenic patients relative to normal controls for low-probability auditory stimuli. Next is described a preliminary report that evaluated whether this P300 reduction reflects a core deficit (trait marker) or clinical symptomatology (state marker). To pursue this question, a group of schizophrenic patients was studied on and off neuroleptic medication. The data showed that improvement in clinical state was highly correlated with increased visual P300 but was uncorrelated with auditory P300. These findings suggest that P300 elicited in the visual modality has the characteristics of a state marker of schizophrenia. In contrast, auditory P300 remains a candidate for a vulnerability trait marker of schizophrenia. The core deficit in schizophrenia thus appears to involve the auditory information-processing system, whereas fluctuations in clinical state may be reflected in the visual processing system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - event related brain potential
KW  - schizophrenia
KW  - auditory information processing system
KW  - visual information processing
KW  - 1988
KW  - Cognitive Processes
KW  - Evoked Potentials
KW  - Schizophrenia
KW  - Brain
KW  - 1988
DO  - 10.1093/schbul/14.2.199
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-014
AN  - 2005-26897-014
AU  - Kety, Seymour S.
T1  - Schizophrenic Illness in the Families of Schizophrenic Adoptees: Findings from the Danish National Sample.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 217
EP  - 222
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kety, Seymour S., Laboratory of Psychology and Psychopathology, NIMH, Bldg. 10, Rm. 4C-212, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-014. PMID: 3201179 Partial author list: First Author & Affiliation: Kety, Seymour S.; Laboratory of Psychology and Psychopathology, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adoptees; Biological Family; Schizophrenia. Minor Descriptor: Schizotypal Personality Disorder. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: Denmark. References Available: Y. Page Count: 6. Issue Publication Date: 1988. 
AB  - The prevalence of schizophrenic illness in the biological and adoptive relatives of schizophrenic adoptees has been examined in a total sample of adoptees in Denmark. The sample was studied in two stages, beginning with the Copenhagen sample of adoptions granted by the courts in the city and county of Copenhagen, and the results have been reported previously. The adoptions granted by the courts in the remainder of Denmark made up the Provincial sample, the preliminary results of which appear to confirm those obtained earlier. Chronic schizophrenia and milder syndromes described as latent, borderline, or uncertain schizophrenia, and in DSM-III as schizotypal personality disorder, were found in both samples to concentrate significantly in the biological relatives of schizophrenic adoptees as compared to their controls, but not in their adoptive relatives. These milder and marginal syndromes resembling schizophrenia occurring in the families of schizophrenic patients confirm the observations of Bleuler and others who succeeded him. Their presence in the biological families of schizophrenic adoptees indicates not only their familial, but also their genetic relationship to schizophrenia, although the specificity of that relationship has not been established. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenic adoptees
KW  - schizophrenic illness
KW  - schizotypal personality disorder
KW  - biological family
KW  - 1988
KW  - Adoptees
KW  - Biological Family
KW  - Schizophrenia
KW  - Schizotypal Personality Disorder
KW  - 1988
DO  - 10.1093/schbul/14.2.217
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-017
AN  - 2005-26897-017
AU  - Pert, Candace B.
AU  - Knight, John G.
AU  - Laing, Peter
AU  - Markwell, Ann K.
T1  - Scenarios for a Viral Etiology of Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 243
EP  - 247
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Pert, Candace B., Section of Brain Biochemistry, Clinical Neuroscience Branch, Bldg. 36, Rm. 2D-30, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-017. PMID: 3059471 Partial author list: First Author & Affiliation: Pert, Candace B.; Section on Brain Biochemistry, Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Etiology; Genetics; Immunology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 5. Issue Publication Date: 1988. 
AB  - Recent discoveries in the field of virus receptors have revolutionized our concepts of viral pathogenesis. The lysis of cells resulting from virus infection or immune recognition of infected cells is seen as merely one facet of a spectrum of pathogenic mechanisms which may be subtle and complex. This is particularly relevant to the central nervous and immune systems which share cell-surface receptors for various neuropeptides and neurotransmitters. A number of viruses are now known to share receptors for such endogenous ligands; indeed, some viruses (e.g., human immunodeficiency virus and vaccinia) may themselves be structural analogs of these ligands. There is, therefore, considerable scope for interference by viruses in the normal functioning of the brain and neuroendocrine systems. Brief reactive psychoses are occasionally reported as acute sequels to viral infections, but generally these are regarded as unrelated to schizophrenia. An opposite viewpoint is presented in the article: i.e., that the only reason these reactive psychoses do not progress to schizophrenia is that the majority of individuals affected are not predisposed genetically to schizophrenia. Conceivably, therefore, the genetic predisposition to schizophrenia may be attributable to genes which determine idiosyncratic differences in immune responsiveness to common viral pathogens. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - viral etiology
KW  - virus infection
KW  - schizophrenia
KW  - central nervous systems
KW  - immune system
KW  - neuroendocrine systems
KW  - genetics
KW  - 1988
KW  - Central Nervous System
KW  - Etiology
KW  - Genetics
KW  - Immunology
KW  - Schizophrenia
KW  - 1988
DO  - 10.1093/schbul/14.2.243
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-018
AN  - 2005-26897-018
AU  - Merril, Carl R.
AU  - Harrington, Michael G.
T1  - Use of Two-Dimensional Electrophoretic Protein Maps in Studies of Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 249
EP  - 254
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Merril, Carl R., Laboratory of Preclinical Pharmacology, NIMH, NIH Clinical Center, Bldg. 10, Rm. 3N218, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-018. PMID: 3059472 Partial author list: First Author & Affiliation: Merril, Carl R.; Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antibodies; Cerebrospinal Fluid; Genes; Proteins; Schizophrenia. Minor Descriptor: Amino Acids; Body Fluids; Technology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1988. 
AB  - High resolution two-dimensional electrophoresis (2DE) and silver staining have provided a technology capable of mapping large numbers of proteins from tissues and body fluids. Further identification of individual proteins that have been visualized by 2DE includes their characterization by immunodetection methods and by obtaining amino acid sequences from which antibody and synthetic oligonucleotide probes can be synthesized. As many as 3,500 individual proteins may be observed on a single electrophoretogram. This capacity to observe gene products permits the scanning of as many as 3.5 megabases of the protein coding regions of the genome for mutational events on each gel, and may also provide evidence concerning abnormal rates of protein synthesis or degradation, posttranslational modifications, and the presence of gene products of exogenous origin. The application of this technology has revealed a pair of abnormal cerebrospinal fluid (CSF) proteins (40KD) in one-third of schizophrenic patients screened. These abnormal proteins have never been observed in CSF from normal controls. However, they have been detected in some diseases of the central nervous system that may be of viral origin. Structural studies on these proteins should provide evidence of their origin, while ongoing studies of brain proteins may provide additional clues about this disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - electrophoretic protein maps
KW  - schizophrenia
KW  - amino acid sequences
KW  - antibody
KW  - oligonucleotide probes
KW  - cerebrospinal fluid
KW  - 1988
KW  - Antibodies
KW  - Cerebrospinal Fluid
KW  - Genes
KW  - Proteins
KW  - Schizophrenia
KW  - Amino Acids
KW  - Body Fluids
KW  - Technology
KW  - 1988
DO  - 10.1093/schbul/14.2.249
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-019
AN  - 2005-26897-019
AU  - Pickar, David
T1  - Perspectives on a Time-Dependent Model of Neuroleptic Action.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 255
EP  - 268
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Pickar, David, Section on Clinical Studies, Clinical Neuroscience Branch, NIMH, NIH Clinical Center, Bldg. 10, Rm. 4N-214, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26897-019. PMID: 2904694 Partial author list: First Author & Affiliation: Pickar, David; Section on Clinical Studies, Clinical Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Dopamine Metabolites; Neuroleptic Drugs; Pathophysiology; Schizophrenia. Minor Descriptor: Dopamine; Homovanillic Acid; Neural Receptors. Classification: Clinical Psychopharmacology (3340). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: 1988. 
AB  - The best support for the hypothesized involvement of central nervous system dopamine systems in the pathophysiology of schizophrenia is the association between the affinity of neuroleptic drugs for the D₂ dopamine receptor and their potency as antipsychotics. Discrepancy between the time course of receptor binding and the development of antipsychotic effects, however, limits this model. Preclinical studies have now shown that activation of presynaptic nigrostriatal and mesolimbic dopamine neurons by acute neuroleptic administration is reversed during chronic administration. Clinically, neuroleptic-induced time-dependent reductions in plasma levels of the dopamine metabolite, homovanillic acid (HVA), have been linked to the antipsychotic response in schizophrenic patients. These data support the notion that slowly developing alterations in presynaptic dopamine activity play a role in the mechanism of action of neuroleptic drugs. Differences between plasma and cerebrospinal fluid (CSF) HVA responses to neuroleptic treatment, although not fully explained, may be related to prominent contributions of mesocortical metabolism to CSF levels of HVA. A time-dependent dopaminergic model of neuroleptic action with implications for the pharmacotherapy of schizophrenia is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuroleptic drugs
KW  - mesolimbic dopamine neurons
KW  - antipsychotic response
KW  - dopamine receptor
KW  - dopamine metabolites
KW  - central nervous system
KW  - pathophysiology
KW  - 1988
KW  - Central Nervous System
KW  - Dopamine Metabolites
KW  - Neuroleptic Drugs
KW  - Pathophysiology
KW  - Schizophrenia
KW  - Dopamine
KW  - Homovanillic Acid
KW  - Neural Receptors
KW  - 1988
DO  - 10.1093/schbul/14.2.255
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 
TY  - JOUR
ID  - 2005-26897-021
AN  - 2005-26897-021
AU  - Shore, David
AU  - Filson, C. Richard
AU  - Johnson, Wayne E.
T1  - Violent Crime Arrests and Paranoid Schizophrenia: The White House Case Studies.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 279
EP  - 281
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Shore, David, Biological and Clinical Factors Research Program, Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-26897-021. PMID: 3201180 Partial author list: First Author & Affiliation: Shore, David; Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hallucinations; Homicide; Legal Arrest; Paranoid Schizophrenia; Violent Crime. Classification: Schizophrenia & Psychotic States (3213); Criminal Law & Adjudication (4230). Population: Human (10); Male (30). Location: US. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 3. Issue Publication Date: 1988. 
AB  - We have previously reported on typically paranoid schizophrenic patients who attempted to see the President or other prominent American political figures based on hallucinations or delusional beliefs. By obtaining arrest records on these White House Cases (WHCs), we were able to determine which individuals had murder or assault arrests before and/or after their WHC hospitalizations. During the 9-12 years following discharge, 31 of the 217 male WHCs (for whom adequate clinical records were available) had murder or assault arrests. Demographic characteristics such as prior violent crime arrest and male gender proved to be much better predictors of future violence than clinical symptom, history, or behavior items. Hospital incidents requiring seclusion and a history of weapons possession were both associated with later violence in WHCs with prior violent crime arrests, while certain clinical symptoms (e.g., persecutory delusions and command hallucinations) may be linked to future violence in WHCs without prior violent crime arrests. These data need replication in other patient samples. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - violent crime arrests
KW  - paranoid schizophrenia
KW  - murder
KW  - assault
KW  - demographic characteristics
KW  - hallucinations
KW  - 1988
KW  - Hallucinations
KW  - Homicide
KW  - Legal Arrest
KW  - Paranoid Schizophrenia
KW  - Violent Crime
KW  - 1988
DO  - 10.1093/schbul/14.2.279
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26897-022
AN  - 2005-26897-022
AU  - Kirch, Darrell G.
AU  - Bigelow, Llewellyn B.
AU  - Korpi, Esa R.
AU  - Wagner, Richard L.
AU  - Zalcman, Steven
AU  - Wyatt, Richard Jed
T1  - Serum Haloperidol Concentration and Clinical Response in Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 2
SP  - 283
EP  - 289
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kirch, Darrell G., Neuropsychiatry Branch, Intramural Research Program, NIMH, Neuropsychiatric Research Hospital at Saint Elizabeths, 2700 Martin Luther King, Jr. Ave., Washington, DC, US, 20032
N1  - Accession Number: 2005-26897-022. PMID: 3201181 Partial author list: First Author & Affiliation: Kirch, Darrell G.; Neuropsychiatric Research Hospital, NIMH, Neuropsychiatric Research Hospital at St. Elizabeths, Washington, DC, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Blood Serum; Drug Therapy; Haloperidol; Schizophrenia; Treatment Outcomes. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Brief Psychiatric Rating Scale DOI: 10.1037/t01554-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: 1988. 
AB  - Previous studies have reported a therapeutic window (i.e., a curvilinear relationship between clinical response and drug level) for haloperidol concentrations in serum or plasma. The authors treated 30 acutely decompensated schizophrenic inpatients with a fixed dose of haloperidol (.4 mg/kg/day). After 6 weeks there was no statistically significant correlation between clinical improvement and serum haloperidol concentration. Fifteen subjects with serum concentrations of 5-15 ng/ml did not differ in clinical improvement compared with 15 subjects who had concentrations above 15 ng/ml. These data are consistent with a therapeutic plateau, rather than a window, and suggest that in most cases there is no clinical advantage to the use of haloperidol doses greater than approximately 30 mg/day in schizophrenic patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - serum haloperidol concentration
KW  - schizophrenia
KW  - clinical response
KW  - blood serum
KW  - 1988
KW  - Blood Serum
KW  - Drug Therapy
KW  - Haloperidol
KW  - Schizophrenia
KW  - Treatment Outcomes
KW  - 1988
DO  - 10.1093/schbul/14.2.283
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09725-001
AN  - 2005-09725-001
AU  - Keith, Samuel J.
AU  - Matthews, Susan M.
T1  - A National Plan for Schizophrenia Research: Panel Recommendations-- Editors' Introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 3
SP  - 343
EP  - 343
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Keith, Samuel J., Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09725-001. Partial author list: First Author & Affiliation: Keith, Samuel J.; Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Etiology; Public Health Services; Schizophrenia; Treatment; Health Care Policy. Minor Descriptor: Mental Health Services. Classification: Schizophrenia & Psychotic States (3213); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 1. Issue Publication Date: 1988. 
AB  - In 1986, the National Institute of Mental Health (NIMH) designated schizophrenia as its foremost research priority. In doing so, NIMH recognized the enormous public health challenge posed by schizophrenia, acknowledged the immense and chronic burden borne by people with this disorder and their families, and made a commitment to rapidly advance the state of knowledge about the illness. The development of the National Plan was undertaken with the awareness that there are no simple and unequivocal answers to the challenges posed by schizophrenia, and the research opportunities detailed in these reports assume that future research efforts will necessarily be challenging, extensive, and complex if they are to provide us with a better understanding of the causes, prevention, and treatment of the most devastating of all mental disorders-schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - public health mental disorders
KW  - treatment
KW  - public health policy
KW  - 1988
KW  - Etiology
KW  - Public Health Services
KW  - Schizophrenia
KW  - Treatment
KW  - Health Care Policy
KW  - Mental Health Services
KW  - 1988
DO  - 10.1093/schbul/14.3.343
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09725-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09725-009
AN  - 2005-09725-009
AU  - Andreasen, Nancy C.
AU  - Carson, Richard
AU  - Diksic, Mirko
AU  - Evans, Alan
AU  - Farde, Lars
AU  - Gjedde, Albert
AU  - Hakim, Antoine
AU  - Lal, Samarthji
AU  - Nair, Neelakanta
AU  - Sedvall, Göran
AU  - Tune, Larry
AU  - Wong, Dean
T1  - Workshop on Schizophrenia, PET, and Dopamine D₂ Receptors in the Human Neostriatum.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 3
SP  - 471
EP  - 484
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Gjedde, Albert, Montreal Neurological Institute and Hospital, 3801 University, Montreal, PQ, Canada, H3A 2B4
N1  - Accession Number: 2005-09725-009. PMID: 2975043 Partial author list: First Author & Affiliation: Andreasen, Nancy C.; University of Iowa, Iowa City, IA, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Neural Receptors; Schizophrenia; Striatum; Tomography. Minor Descriptor: Neurochemistry. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: 1988. 
AB  - Recently, two research groups published numbers for D₂ receptor sites in the neostriatum of drug-naive schizophrenic patients, obtained in vivo by positron emission tomography (PET). One study appeared to confirm the increase of D₂ receptor numbers, while the other study did not. A workshop was convened in Montreal to examine the reasons for the discrepancy between the results obtained by the two groups. The workshop considered patient populations, PET instrumentation and scanning methods, pharmacology, and modeling. The workshop identified differences between the approaches of the two groups that could contribute to the divergent results, including age and chronicity of the patient samples, brain region selected for study, metabolism of the different radioligands in blood and brain, reversibility of binding, PET instrumentation, and complexity of data analysis. The workshop concluded that these initial efforts had made considerable progress in establishing the role of PET in the understanding of the biochemical processes underlying mental illness. In particular, the unique ability to quantify regional neuroreceptor density at different stages in the evolution of the disease has been implemented. At the same time, the work so far and this conference served to identify the main sources contributing to the different findings from the two centers. This information will be important in designing the next phase of the research which will build upon and reconcile these apparent discrepancies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dopamine receptors
KW  - schizophrenics
KW  - tomography
KW  - neostriatum
KW  - 1988
KW  - Dopamine
KW  - Neural Receptors
KW  - Schizophrenia
KW  - Striatum
KW  - Tomography
KW  - Neurochemistry
KW  - 1988
DO  - 10.1093/schbul/14.3.471
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09725-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26896-009
AN  - 2005-26896-009
AU  - McGlashan, Thomas H.
AU  - Carpenter, William T. Jr.
AU  - Bartko, John J.
T1  - Issues of Design and Methodology in Long-Term Followup Studies.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 4
SP  - 569
EP  - 574
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - McGlashan, Thomas H., Chestnut Lodge Research Institute, 500 W. Montgomery Ave., Rockville, MD, US, 20850
N1  - Accession Number: 2005-26896-009. PMID: 3064283 Partial author list: First Author & Affiliation: McGlashan, Thomas H.; Chestnut Lodge Research Institute, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Design; Followup Studies; Longitudinal Studies; Methodology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213); Research Methods & Experimental Design (2260). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 6. Issue Publication Date: 1988. 
AB  - Beginning with Vaillant, followup studies of schizophrenia have devoted increasing attention to issues of design and methodology. The major advances and elements are described here and include: (1) conceptual framework, (2) design, (3) sample representativeness, (4) sample description, (5) data source and quality, (6) measures, (7) reliability, (8) diagnosis, (9) comparison groups, (10) assessment independence, (11) outcome, (12) missing subjects/bias testing, and (13) statistical techniques. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - long-term followup studies
KW  - design
KW  - methodology
KW  - schizophrenia
KW  - 1988
KW  - Experimental Design
KW  - Followup Studies
KW  - Longitudinal Studies
KW  - Methodology
KW  - Schizophrenia
KW  - 1988
DO  - 10.1093/schbul/14.4.569
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26896-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26896-012
AN  - 2005-26896-012
AU  - Mirsky, Allan F.
AU  - Quinn, Olive W.
T1  - The Genain Quadruplets.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1988///
VL  - 14
IS  - 4
SP  - 595
EP  - 612
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Mirsky, Allan F., Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bldg. 10, Rm. 4C-110, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-26896-012. PMID: 2905829 Partial author list: First Author & Affiliation: Mirsky, Allan F.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Followup Studies; Genetics; Multiple Births; Schizophrenia; Severity (Disorders). Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Aged (65 yrs & older) (380). Tests & Measures: Wechsler Abbreviated Scale of Intelligence DOI: 10.1037/t15170-000. References Available: Y. Page Count: 18. Issue Publication Date: 1988. 
AB  - The Genain quadruplets are a unique set of monozygous women who are concordant for schizophrenia but discordant for the severity of their disorder. They were studied by David Rosenthal and colleagues at the National Institute of Mental Health in the late 1950's when they were in their twenties and again in 1981 when they were 51. They are faring about as well now as they ever have in their adult lives. The results of psychological tests, some of which were repeated more than 20 years apart, are discussed, as are the effects of medication on attention and memory. The differential response of the Genains to neuroleptic drugs, as well as certain other findings in the 1981 study, leads to a different conclusion about the discordant severity of their disorder from that reached in 1963 by Rosenthal and Quinn. These observations emphasize the value of long-term followup studies in genetically related individuals, with repeated assessments of the same functions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Genain quadruplets
KW  - monozygous women
KW  - schizophrenia
KW  - disorder severity
KW  - long-term followup studies
KW  - 1988
KW  - Followup Studies
KW  - Genetics
KW  - Multiple Births
KW  - Schizophrenia
KW  - Severity (Disorders)
KW  - 1988
DO  - 10.1093/schbul/14.4.595
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26896-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 119695992
T1  - Differences in platelet enzyme activity between alcoholics and nonalcoholics.
AU  - Tabakoff, B
AU  - Hoffman, P L
AU  - Lee, J M
AU  - Saito, T
AU  - Willard, B
AU  - De Leon-Jones, F
Y1  - 1988/01/21/
N1  - Accession Number: 119695992. Language: English. Entry Date: In Process. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Alcoholism
KW  - Oxidoreductases -- Blood
KW  - Fluorides
KW  - Blood Platelets
KW  - Human
KW  - Adult
KW  - Ethanol -- Pharmacodynamics
KW  - Time Factors
KW  - Population
KW  - Metals -- Pharmacodynamics
KW  - Smoking -- Blood
KW  - Male
KW  - Monoamine Oxidase Inhibitors -- Pharmacodynamics
KW  - Cell Membrane
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 134
EP  - 139
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 318
IS  - 3
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - Blood platelets are an accessible tissue that reflects the activity of many enzymes found in the brain. To investigate the possible effect on such enzymes of long-term consumption of large quantities of ethanol, we assayed the activities of two enzymes, monoamine oxidase and adenylate cyclase, in platelet membranes of men with alcoholism and controls matched for sex and age. We also compared these two groups in terms of the inhibition of platelet monoamine oxidase activity by ethanol in vitro (400 mM), and in terms of the stimulation of adenylate cyclase activity by various agents. There was no significant difference in monoamine oxidase activity between the alcoholics and the controls. However, the inhibition of monoamine oxidase by ethanol was significantly higher in the platelets of alcoholics. The basal activity of adenylate cyclase was the same in platelets from the alcoholics and the controls, but the platelet adenylate cyclase activity after stimulation with guanine nucleotide, cesium fluoride, or prostaglandin E1 was significantly lower in alcoholics. These differences were not associated with age, race, smoking, or illicit drug use, and there was no significant correlation with the duration of problems with alcohol. The changes were long-lasting; cesium fluoride-stimulated adenylate cyclase activity was lower in alcoholic subjects who had abstained from alcohol for one to four years. Discriminant analysis showed that the use of values for the inhibition of monoamine oxidase activity by ethanol and cesium fluoride-stimulated adenylate cyclase activity correctly classified 75 percent of the alcoholics and 73 percent of the controls. These measures may be of value either as indexes of excessive alcohol consumption or as an indication of a predisposition to alcoholism.
SN  - 0028-4793
AD  - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md 20892
U2  - PMID: 3336400.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=119695992&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Looker, Anne C.
AU  - Johnson, Clifford L.
AU  - Woteki, Catherine E.
AU  - Yetley, Elizabeth A.
AU  - Underwood, Barbara A.
T1  - Ethnic and racial differences in serum vitamin A levels of children aged 4-11 years.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/02//
VL  - 47
IS  - 2
M3  - Article
SP  - 247
EP  - 252
SN  - 00029165
AB  - Interpretation of differences in serum vitamin A levels observed between Hispanic and non-Hispanic children may be complicated by confounding environmental factors. Data from the Mexican-American portion of the Hispanic Health and Nutrition Examination Survey and the second National Health and Nutrition Examination Survey were used to explore these differences in 4-11-y-old Mexican Americans and non-Hispanic blacks and whites before and after accounting for vitamin-mineral supplement use and poverty status. Initial differences in mean serum vitamin A levels and prevalences < 20 µg/dL (0.70 µmol/L) or < 25 µg/dL (0.87 µmol/L) among the three ethnic or racial groups were reduced or eliminated after accounting for the two descriptive variables. These results support the hypothesis that differences in serum vitamin A levels between Mexican-American and non-Hispanic children in the United States are due more to environmental factors than to ethnicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Vitamin A
KW  - Body fluids
KW  - Blood plasma
KW  - Serum
KW  - Seroconversion
KW  - Ethnic groups
KW  - nutrition surveys
KW  - vitamin A
N1  - Accession Number: 91710534; Looker, Anne C. 1; Johnson, Clifford L. 1; Woteki, Catherine E. 1; Yetley, Elizabeth A. 2; Underwood, Barbara A. 3; Affiliations: 1: Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville, MD; 2: Division of Nutrition, Food and Drug Administration, Washington, DC; 3: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Feb1988, Vol. 47 Issue 2, p247; Subject Term: Vitamin A; Subject Term: Body fluids; Subject Term: Blood plasma; Subject Term: Serum; Subject Term: Seroconversion; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: nutrition surveys; Author-Supplied Keyword: vitamin A; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Boinski, S.
T1  - Use of a Club by a Wild White-Faced Capuchin (Cebus capucinus) To Attack a Venomous Snake (Bothrops asper).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1988/02//
VL  - 14
IS  - 2
M3  - Article
SP  - 177
EP  - 179
SN  - 02752565
AB  - In Parque Nacional Manuel Antonio, Costa Rica, an adult male Cebus capucinus was observed repeatedly hitting a venomous snake (Bothrops asper) with a branch. Initially a large dead branch overhanging the snake had been broken off in the course of aggressive displays to the snake by the adult and two subadult males. The snake's escape was apparently prevented by the weight of the fallen branch and possibly by the injuries caused by its fall. This is the first direct observation of a capuchin monkey in a natural habitat using a tool. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CAPUCHIN monkeys
KW  - CAPUCHIN monkeys -- Behavior
KW  - AGGRESSIVE behavior in animals
KW  - BOTHROPS
KW  - TOOL use in animals
KW  - PREDATION (Biology)
KW  - PRIMATES
KW  - SNAKES
N1  - Accession Number: 12269671; Boinski, S. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, National Institutes of Health; Source Info: 1988, Vol. 14 Issue 2, p177; Subject Term: CAPUCHIN monkeys; Subject Term: CAPUCHIN monkeys -- Behavior; Subject Term: AGGRESSIVE behavior in animals; Subject Term: BOTHROPS; Subject Term: TOOL use in animals; Subject Term: PREDATION (Biology); Subject Term: PRIMATES; Subject Term: SNAKES; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bellantoni, Michele F.
AU  - Blackman, Marc R.
T1  - Osteoporosis: Diagnostic screening and its place in current care.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1988/02//
VL  - 43
IS  - 2
M3  - Article
SP  - 63
EP  - 70
SN  - 0016867X
N1  - Accession Number: 15839245; Bellantoni, Michele F. 1,2; Blackman, Marc R. 3,4; Source Information: Feb1988, Vol. 43 Issue 2, p63; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 3639
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Malbran, A.
AU  - Siwik, S.
AU  - Frank, M. M.
AU  - Fries, L. F.
T1  - CR1-receptor recycling in phorbol ester-activated polymorphonuclear leucocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1988/02//
VL  - 63
IS  - 2
M3  - Article
SP  - 325
EP  - 330
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Complement-receptor type 1, CR1, which recognizes the C3b cleavage fragment of C3, is present on the membranes of human phagocytic cells, but does not mediate phagocytosis or undergo internalization unless activated by one of a variety of stimuli. Among these stimuli low doses of phorbol esters have been shown to induce a consistently increased expression of CR1, despite apparently continuous receptor internalization. We have studied the fate of internalized receptor-ligand complexes in neutrophils activated with low concentrations of phorbol dibutyrate. In our studies, we followed CR1 with either 125I-C3b, the physiologic ligand, or with 125I-Fab fragments oft monoclonal anti-CR1 antibody. We observed rapid internalization of CR1--C3b complexes by PMN treated with 10 ng/ml (1.98 × 10-8 M) PDBu, consistent in rate and extent with previously reported results using monoclonal antibodies. The fate of the internalized ligand was studied after elution of cell-surface C3b at 0°. Intracellular ligand was externalized in a time- and temperature-dependent fashion, reaching a plateau at 10-15 min. Released C3b was totally TCA precipitable and structurally unaltered, as determined by SDS-PAGE, suggesting that recycling occurs via a prelysosomal predegradative compartment. Loading the cells with chloroquine did not affect this process. A monoclonal anti-CR1 Fab probe behaved in exactly the same manner, suggesting that the recycling of intact ligand-receptor complexes takes place. The possible physiological consequences of this finding are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHAGOCYTOSIS
KW  - BIOLOGICAL membranes
KW  - IMMUNOGLOBULINS
KW  - ANTIGEN-antibody reactions
KW  - CELL receptors
KW  - NEUTROPHILS
KW  - ANTIMALARIALS
KW  - LIGANDS (Biochemistry)
N1  - Accession Number: 14012679; Malbran, A. 1 Siwik, S. 1 Frank, M. M. 1 Fries, L. F. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb88, Vol. 63 Issue 2, p325; Subject Term: PHAGOCYTOSIS; Subject Term: BIOLOGICAL membranes; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGEN-antibody reactions; Subject Term: CELL receptors; Subject Term: NEUTROPHILS; Subject Term: ANTIMALARIALS; Subject Term: LIGANDS (Biochemistry); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rao, Shobini L.
T1  - Cognitive science and psycholinguistics.
JO  - International Social Science Journal
JF  - International Social Science Journal
Y1  - 1988/02//
VL  - 40
IS  - 115
M3  - Article
SP  - 109
SN  - 00208701
AB  - This article focuses on cognitive science and psycholinguistics. Cognitive sciences are fields of enquiry devoted to the understanding of knowledge in a broad sense. The interlinkage of the fields of enquiry collectively described as the cognitive sciences is apparent. Cognition resembles a patterned carpet its separate colored threads being comparable to the different fields of enquiry. Psycholinguistics is an example of the intensive interchange of ideas between two fields leading to the emergence of a new field, this new field markedly hastening the scientific understanding of the common subject of enquiry, language. Language and thought or cognition are closely linked. The uniqueness of psycholinguistics lies in its appreciation of the psychological reality of the complexity of language, in terms of its rules of structure or grammar (Syntax) as well as in terms of its content or meaning (semantics). Psycholinguistics has made it possible to understand that language is largely a psychological process closely linked with knowledge. It emphasizes how language is a product of an individual's psychological processes, while linguistics concentrates on sharing language across individuals and cultures including discreteness, arbitrariness, openness and duality of patterning.
KW  - COGNITIVE science
KW  - PSYCHOLINGUISTICS
KW  - PHILOSOPHY of mind
KW  - LANGUAGE & languages
KW  - SEMANTICS
KW  - SYNTAX (Grammar)
N1  - Accession Number: 5710000; Rao, Shobini L. 1; Affiliation:  1: Lecturer, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, India.; Source Info: Feb88, Vol. 40 Issue 115, p109; Subject Term: COGNITIVE science; Subject Term: PSYCHOLINGUISTICS; Subject Term: PHILOSOPHY of mind; Subject Term: LANGUAGE & languages; Subject Term: SEMANTICS; Subject Term: SYNTAX (Grammar); Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Martinet, Nadine
AU  - Harne, Leslie A.
AU  - Grotendorst, Gary R.
T1  - Identification and Characterization of Chemoattractants for Epidermal Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1988/02//
VL  - 90
IS  - 2
M3  - Article
SP  - 122
EP  - 126
SN  - 0022202X
AB  - We have detected and partially characterized factors that promote the directed migration of mouse epidermal cells in a modified Boyden chamber assay. Smooth muscle cells grown in culture were found to secrete a potent chemoattractant for epidermal cells. This activity was further characterized and compared to the chemotactic activities found in would fluid and conditioned medium from 3T3 L1 cells and with interleukin 1. The migration of epidermal cells during would healing in vivo might be regulated by such factors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - MICE
KW  - MUSCLES
KW  - GROWTH factors
KW  - CELL culture
KW  - EPIDERMIS
N1  - Accession Number: 12462081; Martinet, Nadine 1 Harne, Leslie A. 1 Grotendorst, Gary R. 1; Affiliation:  1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb88, Vol. 90 Issue 2, p122; Subject Term: CELLS; Subject Term: MICE; Subject Term: MUSCLES; Subject Term: GROWTH factors; Subject Term: CELL culture; Subject Term: EPIDERMIS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12462081
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
T1  - Urban Japanese Housewives: At Home and in the Community (Book).
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1988/02//
VL  - 50
IS  - 1
M3  - Book Review
SP  - 297
EP  - 298
SN  - 00222445
AB  - Reviews the book "Urban Japanese Housewives: At Home and in the Community," by Anne E. Imamura.
KW  - HOUSEWIVES
KW  - NONFICTION
KW  - IMAMURA, Anne E.
KW  - URBAN Japanese Housewives: At Home & in the Community (Book)
N1  - Accession Number: 5272146; Schooler, Carmi 1; Affiliation:  1: National Institutes of Health; Source Info: Feb88, Vol. 50 Issue 1, p297; Subject Term: HOUSEWIVES; Subject Term: NONFICTION; Reviews & Products: URBAN Japanese Housewives: At Home & in the Community (Book); People: IMAMURA, Anne E.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fowler, B.
AU  - Gould, E.
T1  - Ultrastructural and biochemical studies of intracellular metal-binding patterns in kidney tubule cells of the scallop Placopecten magellanicus following prolonged exposure to cadmium or copper.
JO  - Marine Biology
JF  - Marine Biology
Y1  - 1988/02//
VL  - 97
IS  - 2
M3  - Article
SP  - 207
EP  - 216
SN  - 00253162
AB  - Sea scallops Placopecten magellanicus, which had been trawl-collected in late November, 1982 off the Rhode Island, USA coast, were exposed to 20 μg of Cd or Cu per liter for a period of seven weeks in a flowing seawater system. Metal analyses of kidneys from both groups indicated uptake of both metals, although the tissue concentrations of Cd declined markedly in the Cu-treated scallops. The ultrastructural appearance of tubule cells of kidneys from Cd-exposed scallops was indistinguishable from controls. In contrast, tubule cells from scallops exposed to Cu showed marked cellular degeneration with loss of concretions. These ultrastructural changes were associated with significant reductions in renal isocitrate dehydrogenase activity in the Cu-treated scallops. Elemental analyses conducted on the kidney concretions and on the cytosolic metal-binding proteins of Cd-exposed scallops showed a 6-to 7-fold increase in Cd content of both these metalsequestering compartments, with concomitant changes in Zn, Mn, and Cu content. Loss of the concretions from Cu-treated scallops precluded analysis of this compartment, but Cu sequestration within cytosolic metal-binding proteins was associated with marked reductions of Zn and Cd from these proteins, suggesting disruption of this cellular mechanism for control of divalent metal cations. These findings support the hypothesis that toxic metal perturbation of normal homeostatic mechanisms that control divalent metal cation bioavailability is important factor in mediating cell injury from these agents. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Marine Biology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Scallops
KW  - Copper
KW  - Cadmium
KW  - Cell death
KW  - Placopecten magellanicus
KW  - Rhode Island
N1  - Accession Number: 71122091; Fowler, B. 1; Gould, E. 2; Affiliations: 1: National Institute of Environmental Health Sciences, National Institutes of Health, 27709 Research Triangle Park USA; 2: National Marine Fisheries Service, Northeast Fisheries Center, Milford Laboratory, National Oceanic and Atmospheric Administration, 06460 Milford USA; Issue Info: 1988, Vol. 97 Issue 2, p207; Thesaurus Term: Scallops; Thesaurus Term: Copper; Thesaurus Term: Cadmium; Thesaurus Term: Cell death; Subject Term: Placopecten magellanicus; Subject: Rhode Island; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3  - 10.1007/BF00391304
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104753719
T1  - Reversible osmotic opening of the blood-brain barrier in mice.
AU  - Fredericks, W R
AU  - Rapoport, S I
Y1  - 1988/02//1988 Feb
N1  - Accession Number: 104753719. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Monosaccharides -- Pharmacokinetics
KW  - Blood-Brain Barrier -- Drug Effects
KW  - Animals
KW  - Brain -- Anatomy and Histology
KW  - Female
KW  - Mice
KW  - Osmosis -- Drug Effects
KW  - Staining and Labeling
KW  - Time Factors
SP  - 266
EP  - 268
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 19
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Unilateral reversible osmotic opening of the blood-brain barrier can be produced in mice. Infusion of 1.8 molal arabinose in water at a rate of 0.64 ml/min for 30 seconds into the internal carotid artery consistently results in ipsilateral brain staining by intravascular Evans blue dye. Osmotic opening is concentration-dependent (threshold, 1.6 molal arabinose) and reversible within 4 hours. No long-term neurologic deficit occurs. These results suggest that reversible osmotic blood-brain barrier opening can be applied to disease models in mice.
SN  - 0039-2499
AD  - Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.
U2  - PMID: 2449747.
DO  - 10.1161/01.STR.19.2.266
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-05457-015
AN  - 2006-05457-015
AU  - Jones, Barbara Pendleton
T1  - Updating for Clinical Neuropsychologists.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/02//
VL  - 33
IS  - 2
SP  - 123
EP  - 124
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05457-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Jones, Barbara Pendleton; Laboratory of Psychology and Psychopathohgy, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Nervous System Disorders; Neuropsychological Assessment; Neuropsychology; Psychiatrists. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Reviewed Item: Grant, Igor (Ed); Adams, Kenneth M. (Ed). Neuropsychological Assessment of Neuropsychiatric Disorders=New York: Oxford University Press, 1986. 536 pp. $45.00; 1986. References Available: Y. Page Count: 2. Issue Publication Date: Feb, 1988. 
AB  - Reviews the book, Neuropsychological Assessment of Neuropsychiatric Disorders edited by Igor Grant and Kenneth M. Adams (1986). This volume deserves a prominent position in the growing collection of works on clinical neuropsychology. It begins with a five-chapter section on methods of neuropsychological assessment, and both in this section and throughout, there is a commendable representation of most of the major approaches in this somewhat faction-ridden field. Overall, this book provides a welcome updating of knowledge in critical areas for clinical neuropsychologists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical neuropsychologists
KW  - neuropsychological assessment
KW  - neuropsychiatric disorders
KW  - 1988
KW  - Nervous System Disorders
KW  - Neuropsychological Assessment
KW  - Neuropsychology
KW  - Psychiatrists
KW  - 1988
U2  - Grant, Igor (Ed); Adams, Kenneth M. (Ed). (1986); Neuropsychological Assessment of Neuropsychiatric Disorders; New York: Oxford University Press, 1986. 536 pp. $45.00; 0-19-503545-3.
DO  - 10.1037/025390
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Patterson, Blossom H.
AU  - Block, Gladys
T1  - Food Choices and the Cancer Guidelines.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/03//
VL  - 78
IS  - 3
M3  - Article
SP  - 282
EP  - 286
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Twenty-four hour dietary recall data from 11,658 adult respondents in the second National Health and Nutrition Examination Survey (NHANES II) (1976-80) were used to examine the American diet in relation to certain of the cancer dietary guidelines from the National Academy of Sciences and the American Cancer Society. The per ¢ who reported consuming any food in those food groups considered protective was small: cruciferous vegetables (18 per ¢); fruits and vegetables high in vitamin A (21 per ¢); high fiber breads and cereals (16 per ¢). The per ¢ consuming foods potentially increasing cancer risk was high: red meat (55 per ¢); bacon and lunch meats (43 per ¢). Proportions of persons eating fruits and vegetables increased with income. Diets were closer to the guidelines for females than males, for Blacks than Whites, and for older than younger Americans.  INSET: Nominations Invited for 1988 International Health Section.... [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH surveys -- Statistical methods
KW  - HEALTH & Nutrition Examination Survey
KW  - DIET
KW  - NUTRITION
KW  - CANCER -- Risk factors
KW  - FOOD consumption
KW  - UNITED States
KW  - NATIONAL Academy of Sciences (U.S.)
KW  - AMERICAN Cancer Society Inc.
N1  - Accession Number: 4685087; Patterson, Blossom H. 1 Block, Gladys 1; Affiliation:  1: Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Mar88, Vol. 78 Issue 3, p282; Subject Term: HEALTH surveys -- Statistical methods; Subject Term: HEALTH & Nutrition Examination Survey; Subject Term: DIET; Subject Term: NUTRITION; Subject Term: CANCER -- Risk factors; Subject Term: FOOD consumption; Subject Term: UNITED States; Company/Entity: NATIONAL Academy of Sciences (U.S.) Company/Entity: AMERICAN Cancer Society Inc.; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Uphoff, Delta E.
AU  - Uphoff, Delta
T1  - SOME THINGS LAMARCKIAN.
JO  - BioScience
JF  - BioScience
Y1  - 1988/03//
VL  - 38
IS  - 3
M3  - Letter
SP  - 144
EP  - 144
SN  - 00063568
AB  - Presents a letter to the editor in response to the article "Mythology in introductory biology," in BioScience 37: 611-614.
KW  - Letters to the editor
KW  - Mythology
N1  - Accession Number: 10109020; Uphoff, Delta E. 1; Uphoff, Delta; Affiliations: 1: Research Biologist, National Cancer Institute, Bethesda, MD 20892; Issue Info: Mar1988, Vol. 38 Issue 3, p144; Subject Term: Letters to the editor; Subject Term: Mythology; Number of Pages: 1/2p; Document Type: Letter; Full Text Word Count: 461
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Abbotts, John
T1  - MENTORS AND APPRENTICES.
JO  - BioScience
JF  - BioScience
Y1  - 1988/03//
VL  - 38
IS  - 3
M3  - Book Review
SP  - 184
EP  - 184
SN  - 00063568
AB  - Reviews the book "Apprentice to Genius: The Making of a Scientific Dynasty," by Robert Kanigel.
KW  - Mentoring in science
KW  - Nonfiction
KW  - Kanigel, Robert
KW  - Apprentice to Genius (Book)
N1  - Accession Number: 10120919; Abbotts, John 1; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892; Issue Info: Mar1988, Vol. 38 Issue 3, p184; Subject Term: Mentoring in science; Subject Term: Nonfiction; Reviews & Products: Apprentice to Genius (Book); People: Kanigel, Robert; Number of Pages: 8/9p; Illustrations: 1 Cartoon or Caricature; Document Type: Book Review; Full Text Word Count: 842
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Nutt, David
AU  - Costello, Michael
T1  - Lithium and Psoriasis: Is 5-HT the Connection?
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1988/03//
VL  - 3
IS  - 1
M3  - Letter
SP  - 67
EP  - 68
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - Presents a letter to the editor about treatment of psoriasis with lithium salts, published in the March 1988 issue of the journal "Human Psychopharmacology."
KW  - LETTERS to the editor
KW  - PSORIASIS
N1  - Accession Number: 12371603; Nutt, David 1 Costello, Michael 2; Affiliation:  1: Laboratory of Clinical Science, National Institute on Alcohol Abuse and Alcoholism.  2: National Institutes of Health, Building 10/3 B19, 9000 Rockville Pike, Bethesda, MD 20892, USA.; Source Info: Mar88, Vol. 3 Issue 1, p67; Subject Term: LETTERS to the editor; Subject Term: PSORIASIS; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - De Jong, Judith A.
AU  - Donovan, Donna Coghlan
T1  - Age-Related Differences in Beliefs, Attitudes and Practices of Priests.
JO  - Journal for the Scientific Study of Religion
JF  - Journal for the Scientific Study of Religion
Y1  - 1988/03//
VL  - 27
IS  - 1
M3  - Article
SP  - 128
EP  - 136
PB  - Wiley-Blackwell
SN  - 00218294
AB  - The article deals with a study which examined the relationship between age, basis of belief, attitude toward religious experience, and frequency of religious practices among Catholic diocesan priests in the United States. The sample consisted of 1027 diocesan priests in the continental United States who completed the Spiritual Orientation Inventory (SOI) upon entrance of their diocese in the Ministry to Priests Program (MPP). For study purposes, subjects were divided into 4 age groups. As a first step in participation of their diocese in the MPP, the SOT was administered to the priests, along with other psychological instruments, in group sessions in their home diocess. Later, at a retreat, the priests privately received feedback from a trained associate who discussed with them the results of their tests. The results of all the instruments were strictly confidential. This study, found age associated with a higher level of certainty. Older priests expressed less doubt about the existence of God and tended toward reliance on logic more and on experience less, than the other groups. The youngest priests found God most naturally through people and events; older groups tended more toward finding God through reading Scripture or other writings and formal worship. Older priests had fewer transcendent experiences and less trust in dreams and imagination than did the younger priests.
KW  - RELIGIOUS psychology
KW  - ATTITUDE (Psychology)
KW  - CLERGY
KW  - BELIEF & doubt
KW  - THEORY of knowledge
KW  - RELIGION
KW  - CATHOLIC Church
KW  - CATHOLIC Church -- Clergy
N1  - Accession Number: 4903295; De Jong, Judith A. 1 Donovan, Donna Coghlan; Affiliation:  1: Staff fellow at the National Institutes of Health (NIH), Bethesda, Maryland; Source Info: Mar88, Vol. 27 Issue 1, p128; Subject Term: RELIGIOUS psychology; Subject Term: ATTITUDE (Psychology); Subject Term: CLERGY; Subject Term: BELIEF & doubt; Subject Term: THEORY of knowledge; Subject Term: RELIGION; Subject Term: CATHOLIC Church; Company/Entity: CATHOLIC Church -- Clergy; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Anderson, Donald M.
AU  - Toni Po-On Cheng, Donald M.
T1  - INTRACELLULAR LOCALIZATION OF SAXITOXINIS IN THE DINOFLAGELLATE <em>GONYAULAX TAMARENSIS</em>.
JO  - Journal of Phycology
JF  - Journal of Phycology
Y1  - 1988/03//
VL  - 24
IS  - 1
M3  - Article
SP  - 17
EP  - 22
PB  - Wiley-Blackwell
SN  - 00223646
AB  - The potent neurotoxin saxitoxin, and possibly several of its derivatives, are localized in two types of sites within the marine dinoflagellate Gonyaulax tamarensis Lehour. Immunocytochemical techniques using a polydonal antibody and epifluorescence microscopy demonstrate toxin localization within the nucleus as well as on the periphery of small granules thought to be starch grains. In the nuclear region, the labelling occurred on or close to the permanently-condensed chromosomes as well as in an area within the two arms of the nucleus in the vicinity of the nucleolus. No binding was observed in a closely-related, non-toxic dinoflagellate. Different binding affinites were observed between the nucleus and the grains at high and low antibody dilutions. This may relate to the polyclonal nature of the antiserum and to the presence off multiple toxius within the G. tamarensis isolate studied. Mechanistic interpretations of these labelling patterns remain speculative, especially the localization of the antigen at the outer edge off starch grains, but the distinct labelling in the nuclear region suggests that saxitoxin, with its two positively charged guanidinium groups, may bind to nucleic acids or nuclear proteins in a manner analogous to the polyamines and other cations. The labelling patterns reported here suggest that the saxitoxins may not simply be secondary metabolites but instead could be important compounds involved in the structure and function of the G. tamarensis genome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Saxitoxin
KW  - Neurotoxic agents
KW  - Dinoflagellates
KW  - Alexandrium tamarense
KW  - Microscopy
KW  - Chromosomes
KW  - antibody
KW  - dinoflagellate
KW  - Gonyaulax tamarensis
KW  - immunocytochemistry
KW  - immunofluorescence
KW  - saxitoxin
N1  - Accession Number: 10986764; Anderson, Donald M. 1; Toni Po-On Cheng, Donald M. 2; Affiliations: 1: Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543; 2: Laboratory of Neurobiology, National Institute of Neurological Communicative Disease and Stroke National Institutes of Health at the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: Mar1988, Vol. 24 Issue 1, p17; Thesaurus Term: Saxitoxin; Thesaurus Term: Neurotoxic agents; Thesaurus Term: Dinoflagellates; Subject Term: Alexandrium tamarense; Subject Term: Microscopy; Subject Term: Chromosomes; Author-Supplied Keyword: antibody; Author-Supplied Keyword: dinoflagellate; Author-Supplied Keyword: Gonyaulax tamarensis; Author-Supplied Keyword: immunocytochemistry; Author-Supplied Keyword: immunofluorescence; Author-Supplied Keyword: saxitoxin; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1529-8817.ep10986764
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=10986764&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Baker, Stuart G.
AU  - Laird, Nan M.
T1  - Regression Analysis for Categorical Variables With Outcome Subject to Nonignorable Nonresponse.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1988/03//
VL  - 83
IS  - 401
M3  - Article
SP  - 62
SN  - 01621459
AB  - We develop a log-linear model for categorical response subject to nonignorable nonresponse. The paper differs from Fay (1986) in its focus on estimation and hypothesis testing in a regression setting, as opposed to imputation in a multivariate setting. We present several new results concerning the existence of solutions on the boundary of the parameter space and the construction of confidence intervals for estimates. We illustrate the method by estimating the proportion of voters preferring Truman in a 1948 preelection poll (Mosteller, Hyman, McCarthy, Marks, and Truman 1949). Results may depend strongly on the model assumed for nonresponse; goodness-of-fit tests are available for comparing alternative models. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - REGRESSION analysis
KW  - STATISTICAL hypothesis testing
KW  - MULTIVARIATE analysis
KW  - MATHEMATICAL models
KW  - LOG-linear models
KW  - CONFIDENCE intervals
KW  - HYPOTHESIS
KW  - EM algorithm
KW  - Missing data.
KW  - Sample survey
N1  - Accession Number: 4609860; Baker, Stuart G. 1; Laird, Nan M. 2; Affiliations: 1: Staff Fellow, Biometry Branch, Division of Cancer Prevention and Control, National Institutes of Health (NIH), Bethesda, MD 20892-4200.; 2: Professor of Biostatistics, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.; Issue Info: Mar1988, Vol. 83 Issue 401, p62; Thesaurus Term: REGRESSION analysis; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: MATHEMATICAL models; Subject Term: LOG-linear models; Subject Term: CONFIDENCE intervals; Subject Term: HYPOTHESIS; Author-Supplied Keyword: EM algorithm; Author-Supplied Keyword: Missing data.; Author-Supplied Keyword: Sample survey; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Jasiukaitis, Paul
AU  - Hakerem, Gad
T1  - The Effect of Prestimulus Alpha Activity on the P300.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1988/03//
VL  - 25
IS  - 2
M3  - Article
SP  - 157
EP  - 165
SN  - 00485772
AB  - Trials on which highly discrepant, auditory `oddball' stimuli were presented were sorted into two bins on the basis of prestimulus alpha band RMS magnitude. The trial bins were then separately averaged to produce a `high alpha' auditory ERP (event-related potential) and a `low alpha' ERP for each subject. Study 1 found that larger amplitude P300s were obtained in the `high alpha' ERP. No effect of alpha was found on the N 100. Study 2 employed extra factors of stimulus intensity change (increases and decreases) and alpha measurement period (before and after the `oddball' stimulus). It was found that P300 amplitude enhancement was independent of both stimulus intensity and the amount of alpha poststimulus. The data are discussed in terms of cascaded inhibition from the mesencephalic reticutar formation to nucleus reticularis of the thalamus to a thalamo-cortical system responsible for the generation of both alpha and the P300. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOKED potentials (Electrophysiology)
KW  - BRAIN
KW  - PSYCHOPHYSIOLOGY
KW  - Alpha activity
KW  - Event-related potentials (ERPs)
KW  - Neuronal inhibition and rebound.
KW  - P300 component
N1  - Accession Number: 11027166; Jasiukaitis, Paul 1 Hakerem, Gad 2; Affiliation:  1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health.  2: Department of Psychology, Queens College, City University of New York.; Source Info: Mar1988, Vol. 25 Issue 2, p157; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: BRAIN; Subject Term: PSYCHOPHYSIOLOGY; Author-Supplied Keyword: Alpha activity; Author-Supplied Keyword: Event-related potentials (ERPs); Author-Supplied Keyword: Neuronal inhibition and rebound.; Author-Supplied Keyword: P300 component; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-8986.ep11027166
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11027166&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Lang, W. Robert
AU  - Snyder, Frederick R.
AU  - Lozovsky, David
AU  - Kaistha, Vivek
AU  - Kaczaniuk, Mary A.
AU  - Jaffe, Jerome H.
T1  - Geographic Distribution of Human Immunodeficiency Virus Markers in Parental Drug Abusers.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/04//
VL  - 78
IS  - 4
M3  - Editorial
SP  - 443
EP  - 446
PB  - American Public Health Association
SN  - 00900036
AB  - Drug abuse treatment programs in six regions of the United States collaborated in a study aimed at monitoring trends in the seroprevalence of human immunodeficiency virus (HIV) antibodies. The wide disparities in HIV seroprevalence in the face of similarities in drug using behavior have important implications for prevention. In the New York City area (Harlem, Brooklyn), 61 per cent; of samples (N=280) obtained in late 1986 were positive, up from 50 per cent; of samples (N=585) in early 1985. In Baltimore, Maryland, 29 per cent; of samples (N = 184) representing 11 programs were positive. In contrast, samples from programs distant from the Northeast corridor had far lower rates: Denver, Colorado 5 per cent; (N=100); San Antonio, Texas 2 per cent; (N=106); Southern California, 1.5 per cent; (N=413); and Tampa, Florida, 0 per cent; (N=102). Contrary to expectations, there was no corresponding difference in reported lifetime needle sharing experiences, which ranged from 70 per cent; in New York to 99 per cent; in San Antonio. HIV seropositivity was associated only with geographic location and ethnicity; however, because needle sharing is practiced by parenteral drug abusers in areas where seroprevalence is still relatively low, these areas are potentially vulnerable to the same catastrophic spread seen in the Northeast. A window of opportunity exists where prompt, vigorous, and aggressive efforts at prevention could have major impact. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse
KW  - SUBSTANCE abuse
KW  - HIV antibodies
KW  - VIRAL antibodies
KW  - HIV (Viruses)
KW  - HIV infections
KW  - MEDICAL care
KW  - COMMUNITY health services
KW  - UNITED States
N1  - Accession Number: 4687436; Lang, W. Robert 1 Snyder, Frederick R. 1 Lozovsky, David 1 Kaistha, Vivek 1 Kaczaniuk, Mary A. 1 Jaffe, Jerome H. 1; Affiliation:  1: Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland; Source Info: Apr88, Vol. 78 Issue 4, p443; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: HIV antibodies; Subject Term: VIRAL antibodies; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: MEDICAL care; Subject Term: COMMUNITY health services; Subject Term: UNITED States; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 4p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kingman, Albert
AU  - Little, Wayne
AU  - Gomez, Irma
AU  - Heitetz, Stanley B.
AU  - Driscoll, William S.
AU  - Sheats, Rose
AU  - Supan, Paul
T1  - Salivary levels of Streptococcus mutans and lactobacilli and dental caries experiences in a US adolescent population.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1988/04//
VL  - 16
IS  - 2
M3  - Article
SP  - 98
EP  - 103
SN  - 03015661
AB  - Dental caries exams and saliva samples were obtained from 541 adolescents, aged 10-15. initially and after 17 months as pan of a 3-yr longitudinal study investigating the relationships of dietary intakes, specific microorganisms in saliva, and the prevalence and incidence of dental caries. The mean DMFS score detected in these subjects initially was 4.61, and they developed an average of 1.38 new DMFS during the first 17-month period. Initially, S. mutans and lactobacilli were detected in 64% and 56% of these subjects, respectively. Subjects with low levels of S. mutans and lactobacilli had significantly lower initial DMFS scores and developed significantly fewer new DMES than subjects with high counts. The predictive values of a positive result for S. mutans or lactobacilli assays were low (31 % and 39%), but those for a negative result were high (81% and 84%). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SALIVA
KW  - STREPTOCOCCUS mutans
KW  - STREPTOCOCCUS
KW  - LACTOBACILLUS
KW  - DENTAL caries
KW  - DENTAL pathology
KW  - TEENAGERS
KW  - UNITED States
KW  - caries incidence
KW  - caries prevalence
KW  - lactobacilli
KW  - S. mutans
N1  - Accession Number: 12015316; Kingman, Albert 1 Little, Wayne 1 Gomez, Irma 1 Heitetz, Stanley B. 1 Driscoll, William S. 1 Sheats, Rose 1 Supan, Paul 1; Affiliation:  1: Epidemiology and Oral Diseases Prevention Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1988, Vol. 16 Issue 2, p98; Subject Term: SALIVA; Subject Term: STREPTOCOCCUS mutans; Subject Term: STREPTOCOCCUS; Subject Term: LACTOBACILLUS; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: TEENAGERS; Subject Term: UNITED States; Author-Supplied Keyword: caries incidence; Author-Supplied Keyword: caries prevalence; Author-Supplied Keyword: lactobacilli; Author-Supplied Keyword: S. mutans; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12015316
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12015316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05459-060
AN  - 2006-05459-060
AU  - Optican, Lance M.
T1  - Understanding movement: Oculomotor progress and skeletalmotor confusion.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/04//
VL  - 33
IS  - 4
SP  - 366
EP  - 367
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05459-060. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Optican, Lance M.; Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Eye Movements; Motor Processes. Minor Descriptor: Brain. Classification: Physiological Processes (2540). Population: Human (10). Reviewed Item: Freund, H. -J. (Ed); Büttner, U. (Ed); Cohen, B. (Ed); Noth, J. (Ed). The Oculomotor and Skeletalmotor Systems: Differences and Similarities, Vol. 64=Amsterdam: Elsevier, 1986. 432 pp. $118.50 (Dfl. 320,-); 1986. Page Count: 2. Issue Publication Date: Apr, 1988. 
AB  - Reviews the book, The Oculomotor and Skeletalmotor Systems: Differences and Similarities, Vol. 64 edited by H.-J. Freund, U. Büttner, B. Cohen, and J. Noth (1986). The content of this book, a volume in the 'Progress in Brain Research' series is based on a symposium held in 1984 to bring together researchers from the fields of eye and body movements to discuss similarities and differences in their respective systems The editors state in the preface that 'a comparison of this kind was meant to stimulate new approaches based on cooperative aspects rather than to provide an update about the state of the art in either field.' To a certain extent, that intent was achieved; the book is not up to date with regard to research in those fields. In particular, the rapid progress in mathematical models of oculomotor control was not represented. It seems safe to say that one of the dominant forces in oculomotor studies in the past 10 or 15 years has been the progress in models accurate enough to simulate eye movements and provide predictions about the control of movement. The absence of a section on modeling makes the book even more dated than it might otherwise appear. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - oculomotor systems
KW  - skeletalmotor systems
KW  - brain research
KW  - 1988
KW  - Eye Movements
KW  - Motor Processes
KW  - Brain
KW  - 1988
U2  - Freund, H. -J. (Ed); Büttner, U. (Ed); Cohen, B. (Ed); Noth, J. (Ed). (1986); The Oculomotor and Skeletalmotor Systems: Differences and Similarities, Vol. 64; Amsterdam: Elsevier, 1986. 432 pp. $118.50 (Dfl. 320,-); 0-444-80655-5.
DO  - 10.1037/025636
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Davis, Michael D.
AU  - Kaufman, Seymour
AU  - Milstien, Sheldon
T1  - The auto-oxidation of tetrahydrobiopterin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1988/04/15/
VL  - 173
IS  - 2
M3  - Article
SP  - 345
EP  - 351
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The product of the aerobic oxidation of tetrahydrobiopterin, quinonoid dihydrobiopterin, is unstable and rapidly rearranges to form a 7,8-dihydropteridine. Kaufman [Kaufman, S. (1967) J. Biol. Chem. 242, 3934–3943] identified tee stable product produced in 0.1 M phosphate pH 6.8, as 7,8-dihydrobiopterin. However, Armarego et al. [Armasego, W. L. F., Raadles, D. and Taguchi, H. (1983) Eur. J. Biochem. 155 393–403] questioned this assignment because they found that the dihydroxypropyl group on C-6 was eliminated and 7,8-dihydropterin was the predominant product when the aerobic oxidation was performed in 0.1 M Tris pH 7.6. In the present study we demonstrate that the rearrangement of the unstable quinonoid dihydrobiopterin results in a mixture of these two 7,8-dihydropteridines at neutral pH, 25°C. Furthermore, we find that the loss or retention of the alkyl side. chain is not solely dependent on the pH of the reaction mixture, as was previously assumed by Armarego et al., but rather is strongly influenced by the temperature and the type of buffer. In additton, we describe a new method for quantifying the relative amounts of these two 7,8-dihydropteridines in mixtures of unknown concentrations. This method relies on multicomponent analysis of second derivative spectra and results in values which agree with the concentrations determined directly by HPLC. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OXIDATION
KW  - TETRAHYDROBIOPTERIN
KW  - ENZYMES -- Analysis
KW  - COENZYMES
KW  - TEMPERATURE
KW  - NEUROCHEMISTRY
N1  - Accession Number: 14317086; Davis, Michael D. 1 Kaufman, Seymour 1 Milstien, Sheldon 1; Affiliation:  1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland; Source Info: 4/15/88, Vol. 173 Issue 2, p345; Subject Term: OXIDATION; Subject Term: TETRAHYDROBIOPTERIN; Subject Term: ENZYMES -- Analysis; Subject Term: COENZYMES; Subject Term: TEMPERATURE; Subject Term: NEUROCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Feigl, Polly
AU  - Glaefke, Gwen
AU  - Ford, Leslie
AU  - Diehr, Paula
AU  - Chu, Joe
T1  - Studying Patterns of Cancer Care: How Useful is the Medical Record?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/05//
VL  - 78
IS  - 5
M3  - Article
SP  - 526
EP  - 533
PB  - American Public Health Association
SN  - 00900036
AB  - Records of hospital inpatients were abstracted for 5,000 newly diagnosed cancer patients admitted in 1982-83 to 17 Comprehensive Cancer Centers and 17 Community Hospital Oncology Programs. Generally available data items (silent record rate less than 5 per cent for the typical institution) included: age, race, sex, dates of hospitalization, zip code of residence, pathological stage, dates of biopsy and surgery, numbers of nodes examined and positive, certain diagnostic procedures, and some radiotherapy descriptors. For other data items, there was enormous variability in completeness and high institution-to-institution variation. Record completeness did not differ consistently between comprehensive and community cancer centers. We conclude that the hospital patient record is useful for tracking the frequency of surgical and related events. However, studies of diagnostic and therapeutic procedures should not rely solely on the hospital medical record due to the high rates of silent records.  INSET: Medical Literature at Risk of Deterioration from Acid in Paper. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL records
KW  - CANCER patients
KW  - MEDICAL care
KW  - COMMUNITY centers
KW  - ONCOLOGY nursing
KW  - ONCOLOGIC surgery
KW  - CANCER
KW  - CANCER -- Diagnosis
KW  - RADIOTHERAPY
KW  - HOSPITAL records
KW  - PATHOPHYSIOLOGY
N1  - Accession Number: 4686931; Feigl, Polly 1 Glaefke, Gwen 1 Ford, Leslie 2 Diehr, Paula 1 Chu, Joe 1; Affiliation:  1: Fred Hutchinson Research Center.  2: National Cancer Institute, Division of Cancer Prevention and Control.; Source Info: May88, Vol. 78 Issue 5, p526; Subject Term: MEDICAL records; Subject Term: CANCER patients; Subject Term: MEDICAL care; Subject Term: COMMUNITY centers; Subject Term: ONCOLOGY nursing; Subject Term: ONCOLOGIC surgery; Subject Term: CANCER; Subject Term: CANCER -- Diagnosis; Subject Term: RADIOTHERAPY; Subject Term: HOSPITAL records; Subject Term: PATHOPHYSIOLOGY; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 624110 Child and Youth Services; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Freimuth, Vicki S.
AU  - Hammond, Sharon L.
AU  - Stein, Judith A.
T1  - Health Advertising: Prevention for Profit.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/05//
VL  - 78
IS  - 5
M3  - Article
SP  - 557
EP  - 561
PB  - American Public Health Association
SN  - 00900036
AB  - The National Cancer Institute (NCI) estimates on the basis of current knowledge alone that, at a minimum, 30,000 lives could be saved in the year 2000 if Americans would modify their dietary habits. A recent innovative way of responding to this challenge was the Kellogg Company/NCI All-Bran advertising campaign. This paper will describe the campaign, and its impact on consumers, cereal industry sales, food industry advertising practices, health regulatory policy, and the organizational credibility of both NCI and Kellogg. For the past three years, Kellogg has included NCI's cancer prevention messages in their advertisements for All-Bran cereal and on their bran cereal boxes. This collaborative effort has stimulated considerable controversy over whether the health claims made on the cereal label are in violation of federal food labeling regulations. Meanwhile, research has demonstrated the positive impact of the campaign on consumer's knowledge and behavior regarding fiber as well as on Kellogg's profits. Other manufacturers are anxious to jump on the "branwagon"; however, many unanswered questions remain about this new approach to health advertising. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH promotion
KW  - ADVERTISING campaigns
KW  - ADVERTISING -- Health products
KW  - MEDICAL policy
KW  - FOOD labeling -- Law & legislation
KW  - CONSUMER behavior
KW  - PRODUCT acceptance
KW  - CEREAL products industry
KW  - FOOD industry
KW  - UNITED States
KW  - KELLOGG Co.
KW  - NATIONAL Cancer Institute (U.S.)
N1  - Accession Number: 4687122; Freimuth, Vicki S. 1 Hammond, Sharon L. 1 Stein, Judith A. 2; Affiliation:  1: Department of Communication Arts and Theatre, University of Maryland, College Park, MD 20742.  2: National Eye Institute, Bethesda, MD 20892.; Source Info: May88, Vol. 78 Issue 5, p557; Subject Term: HEALTH promotion; Subject Term: ADVERTISING campaigns; Subject Term: ADVERTISING -- Health products; Subject Term: MEDICAL policy; Subject Term: FOOD labeling -- Law & legislation; Subject Term: CONSUMER behavior; Subject Term: PRODUCT acceptance; Subject Term: CEREAL products industry; Subject Term: FOOD industry; Subject Term: UNITED States; Company/Entity: KELLOGG Co. DUNS Number: 080600430 Ticker: K Company/Entity: NATIONAL Cancer Institute (U.S.) DUNS Number:  Ticker: ; NAICS/Industry Codes: 541870 Advertising Material Distribution Services; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hasin, Deborah S.
AU  - Grant, Bridget F.
AU  - Endicott, Jean
AU  - Harford, Thomas C.
T1  - Cocaine and Heroin Dependence Compared in Poly-Drug Abusers.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/05//
VL  - 78
IS  - 5
M3  - Article
SP  - 567
EP  - 569
PB  - American Public Health Association
SN  - 00900036
AB  - Concerns about cocaine dependence are increasing, in some ways replacing heroin as the focus of highest concern. We compared cocaine and heroin dependence by levels of cocaine and heroin use in poly-drug users. While dependence indicators differed markedly between regular and sporadic users of these drugs, cocaine dependence indicators did not differ from heroin dependence indicators. Implications of the findings are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COCAINE abuse
KW  - HEROIN abuse
KW  - DRUG abuse
KW  - SUBSTANCE abuse
KW  - ALCOHOLISM
KW  - MEDICAL statistics
KW  - UNITED States
KW  - AMERICAN Psychiatric Association
KW  - DIAGNOSTIC & Statistical Manual (Book)
N1  - Accession Number: 4687152; Hasin, Deborah S. 1,2 Grant, Bridget F. 3 Endicott, Jean 4 Harford, Thomas C. 3; Affiliation:  1: Research Scientist, New York State psychiatric Institute, 722 West 168th Street, Box 123, New York, NY 10032.  2: Assistant Professor , Department of Epidemiology, School of Public Health, Columbia University.  3: National Institute on Alcohol Abuse and Alcoholism.  4: Columbia University and NYS Psychiatric Institute.; Source Info: May88, Vol. 78 Issue 5, p567; Subject Term: COCAINE abuse; Subject Term: HEROIN abuse; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOLISM; Subject Term: MEDICAL statistics; Subject Term: UNITED States; Company/Entity: AMERICAN Psychiatric Association DUNS Number: 020292348; Reviews & Products: DIAGNOSTIC & Statistical Manual (Book); Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cantor, Kenneth P.
AU  - Blair, Aaron
AU  - Everett, George
AU  - VanLier, Stephanie
AU  - Burmeister, Leon
AU  - Dick, Fred R.
AU  - Gibson, Robert W.
AU  - Schuman, Leonard
T1  - Hair Dye Use and Risk of Leukemia and Lymphoma.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/05//
VL  - 78
IS  - 5
M3  - Article
SP  - 570
EP  - 571
PB  - American Public Health Association
SN  - 00900036
AB  - Data from a population-based case-control study of incident leukemia and non-Hodgkin's lymphoma among adult men in Iowa and Minnesota were used to evaluate risk associated with hair dye use. The relative risk for ever using hair dyes was 1.8 (95% confidence interval [CI] = 1.1-2.7) among leukemia patients, and 2.0 (CI = 1.3-3.0) among cases with non-Hodgkin's lymphoma. There was a suggestion of increased risk with extent of hair dye use. Given the widespread use of hair coloring products, these observations deserve more detailed evaluation in populations where the exposure is relatively common. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR -- Dyeing & bleaching
KW  - HAIR care products
KW  - LEUKEMIA
KW  - LYMPHOMAS
KW  - RETICULO-endothelial system -- Tumors
KW  - MEN -- Health
KW  - MEDICAL statistics
KW  - HEALTH surveys -- United States
KW  - UNITED States
N1  - Accession Number: 4687162; Cantor, Kenneth P. 1 Blair, Aaron 1 Everett, George 2 VanLier, Stephanie 2 Burmeister, Leon 2 Dick, Fred R. 2 Gibson, Robert W. 3 Schuman, Leonard 3; Affiliation:  1: National Cancer Institute, Environmental Epidemiology Branch.  2: University of Iowa College of Medicine.  3: University of Minnesota School of Public Health.; Source Info: May88, Vol. 78 Issue 5, p570; Subject Term: HAIR -- Dyeing & bleaching; Subject Term: HAIR care products; Subject Term: LEUKEMIA; Subject Term: LYMPHOMAS; Subject Term: RETICULO-endothelial system -- Tumors; Subject Term: MEN -- Health; Subject Term: MEDICAL statistics; Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kahn, Joan R.
AU  - Kalsbeek, William D.
AU  - Hofferth, Sandra L.
T1  - National Estimates of Teenage Sexual Activity: Evaluating the Comparability of Three National Surveys.
JO  - Demography
JF  - Demography
Y1  - 1988/05//
VL  - 25
IS  - 2
M3  - Article
SP  - 189
EP  - 204
SN  - 00703370
AB  - In this article, we examine the reliability with which teenage sexual activity was reported in three recent national surveys. Unlike other study-effects analyses of objective demographic phenomena such as births and marriages, ours focuses on a more sensitive question-age at first intercourse as reported in three very different surveys. Specifically, we compare reports for the 1959-1963 cohort in the 1979 Kantner-Zelnik Study of Young Women, the 1982 National Survey of Family Growth, and the 1983 wave of the National Longitudinal Survey of Youth. For the ages when the majority of teens become sexually active (16-19), the three surveys provide comparable estimates of early sexual activity. For the younger teen ages, however, there is some disagreement among the estimates. Nevertheless, all three studies produce consistent estimates of the determinants of sexual activity throughout the teen years. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEMOGRAPHY
KW  - TEENAGERS -- Sexual behavior
KW  - SOCIAL surveys
KW  - MARRIAGE
KW  - YOUNG women
KW  - AGE groups
KW  - EPHEMERA—PERSONAL NARRATIVES
N1  - Accession Number: 16799665; Kahn, Joan R. 1; Kalsbeek, William D. 2; Hofferth, Sandra L. 3; Affiliations: 1: Department of Sociology, University of Maryland, College Park, Maryland 20742.; 2: Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27514.; 3: Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute for Child Health and Human Development, Bethesda, Maryland 20892.; Issue Info: May1988, Vol. 25 Issue 2, p189; Thesaurus Term: DEMOGRAPHY; Subject Term: TEENAGERS -- Sexual behavior; Subject Term: SOCIAL surveys; Subject Term: MARRIAGE; Subject Term: YOUNG women; Subject Term: AGE groups; Author-Supplied Keyword: EPHEMERA—PERSONAL NARRATIVES; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Breznitz, Zvia
AU  - Friedman, Sarah L.
T1  - TODDLERS' CONCENTRATION: DOES MATERNAL DEPRESSION MAKE A DIFFERENCE?
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1988/05//
VL  - 29
IS  - 3
M3  - Article
SP  - 267
EP  - 279
SN  - 00219630
AB  - Twenty-five mother-toddler dyads with depressed mothers were compared with 25 dyads with well mothers on measures of attention during 20 mm of spontaneous play in a home-like setting. Children of depressed women focused attention on more objects for shorter durations. Group differences could be accounted for by mothers' involvement in their children's play. Depressed women initiated and terminated more instances of attention to objects than well mothers. Correlations between maternal behaviors and children's attention were statistically significant. Results support the hypothesis that poorer attention of children of depressed women is at least in part mediated by inculcation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Child Psychology & Psychiatry & Allied Disciplines is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOTHER & child
KW  - DEPRESSION in women
KW  - MATERNAL deprivation in infants
KW  - AMUSEMENTS
KW  - MATERNAL love
KW  - TODDLERS -- Psychology
KW  - Attention
KW  - concentration
KW  - maternal depression
N1  - Accession Number: 11987715; Breznitz, Zvia 1 Friedman, Sarah L. 1; Affiliation:  1: National Institute of Mental Health, University of Haifa, Israel.; Source Info: May1988, Vol. 29 Issue 3, p267; Subject Term: MOTHER & child; Subject Term: DEPRESSION in women; Subject Term: MATERNAL deprivation in infants; Subject Term: AMUSEMENTS; Subject Term: MATERNAL love; Subject Term: TODDLERS -- Psychology; Author-Supplied Keyword: Attention; Author-Supplied Keyword: concentration; Author-Supplied Keyword: maternal depression; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1469-7610.ep11987715
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Woodley, David T.
AU  - Stanley, John R.
AU  - Reese, Melinda J.
AU  - O'keefe, Edward J.
T1  - Human Dermal Fibroblasts Synthesize Laminin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1988/05//
VL  - 90
IS  - 5
M3  - Article
SP  - 679
EP  - 683
SN  - 0022202X
AB  - Laminin, a glycoprotein of approximately 900,000 daltons, is a major component of the basement membrane that separates the epidermis from dermis in human skin. Previous studies have shown that keratinocytes and other epithelial cells synthesize laminin and utilize it for attachment to other extracellular matrices such as heparan sulfate proteoglycan and basement membrane collagen. The relationships between phenotypically normal mesenchymal cells and laminin have been much less emphasized in the literature. In this study, we have used antibodies that specifically label the A and B chains of laminin (but not fibronectin or other unrelated proteins) by Western blot analysis to immunoprecipitate biosynthetically derived laminin from [35S] methionine labeled cultures of neonatal and adult human skin fibroblasts. To be sure that the precipitated bands were laminin and not fibronectin, which has a molecular size very close to that of the laminin B chains, experiments were performed in which fibronectin was removed from the radiolabeled proteins by first immunoprecipitating with antifibronectin antibody and then sequentially immunoprecipitating laminin from the fibronectin-depleted supernates with antilaminin antibody. These experiments definitively demonstrate that human dermal fibroblasts synthesize and secrete laminin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LAMINA epithelialis
KW  - DERMIS
KW  - FIBROBLASTS
KW  - GLYCOPROTEINS
KW  - BASAL lamina
KW  - EPIDERMIS
N1  - Accession Number: 12560880; Woodley, David T. 1 Stanley, John R. 2 Reese, Melinda J. 1 O'keefe, Edward J. 1; Affiliation:  1: Department of Dermatology, UNC School of Medicine, Chapel Hill, North Carolina.  2: Department of Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May88, Vol. 90 Issue 5, p679; Subject Term: LAMINA epithelialis; Subject Term: DERMIS; Subject Term: FIBROBLASTS; Subject Term: GLYCOPROTEINS; Subject Term: BASAL lamina; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12560880
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ruchkin, Daniel S.
AU  - Johnson Jr., Ray
AU  - Mahaffey, David
AU  - Sutton, Samuel
T1  - Toward a Functional Categorization of Slow Waves.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1988/05//
VL  - 25
IS  - 3
M3  - Article
SP  - 339
EP  - 353
SN  - 00485772
AB  - This study is concerned with slowly varying, long-duration brain event-related potential (ERP) components, referred to as Slow Wave activity. Slow Wave activity can be observed in the epoch following P3b, suggesting that it reflects further processing invoked by increased task demands, beyond the processing that underlies P3b. The present experiment was designed to distinguish Slow Wave activity related to specific types of task demands which arise during difficult perceptual (pattern recognition) and conceptual (arithmetic) mental operations.  Three late ERP components that respond differentially in amplitude to manipulation of perceptual and conceptual difficulty were identified: 1) A P3b, with a topography focused about P[sub z], evidently related to the subjective categorization of easy and difficult conceptual operations, that increased when the subjective low-probability operation was performed; 2) A longer latency, centro-parietal positive Slow Wave that increased directly with perceptual difficulty but was not affected by conceptual difficulty; 3) A very long latency negative Slow Wave, broadly distributed over centro- posterior scalp, that increased directly with conceptual difficulty while its onset was delayed when perceptual difficulty increased. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOKED potentials (Electrophysiology)
KW  - BRAIN
KW  - SCALP
KW  - Event-related potentials
KW  - Information processing.
KW  - Mental arithmetic
KW  - P3b
KW  - Slow Wave
N1  - Accession Number: 11027371; Ruchkin, Daniel S. 1 Johnson Jr., Ray 2 Mahaffey, David 3 Sutton, Samuel 4; Affiliation:  1: Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland.  2: Clinical Neuropsychology Section, National institute of Neurological, Communicative Disorders & Stroke, Medical Neurology Branch, National institutes of Health, Bethesda, Maryland.  3: ARD Corporation, Columbia, Maryland.  4: Department of Psychophysiology, New York State Psychiatric Institute, New York, New York.; Source Info: May1988, Vol. 25 Issue 3, p339; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: BRAIN; Subject Term: SCALP; Author-Supplied Keyword: Event-related potentials; Author-Supplied Keyword: Information processing.; Author-Supplied Keyword: Mental arithmetic; Author-Supplied Keyword: P3b; Author-Supplied Keyword: Slow Wave; Number of Pages: 15p; Document Type: Article
L3  - 10.1111/1469-8986.ep11027371
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shj-Xian Cao
AU  - Schecuter, Alan N.
T1  - Nuclease hypersensitivity in the β-globin gene region of K562 cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1988/05/02/
VL  - 173
IS  - 3
M3  - Article
SP  - 517
EP  - 522
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have investigated chromatin structure in the β-globin gene region of the K562 human erythroleukemic cell tine by using S1 and DNase I nuclease sensitivity assays. Despite the lack of β-globin gene expression in these cells, we find nuclease-hypersensitive sites to these enzymes in its 5' and 3' flanking regions in K562 chromatin, This result is in contrast to previous reports in which no hypersensitive sites were found in the immediate vicinity of this gene. In the 3' region, one major hypersensitive site at 0.9 kpb 3' and three minor hypersensitive sites at 0.7 kbp, 0.5 kbp 3' and 0.2 kbp 5' of the polyadenylation site were observed; these sites are very similar to those found in fetal liver and adult bone marrow cells in which the β-globin gene is expressed. We find hypersensitive sites to both enzymes in the 5' region of the β-globin gene: a major site 0.8 kbp 5' to the cap site, and two minor sites 1.2 and 1.5 kbp 5' to the cap site. The -0.8 kbp site is also present in plasmids containing the β-globin gene. Our results suggest that the lack of β-globin gene expression may be related to the lack of hypersensitivity sites in the immediate (150 bp) 5' flanking region of the β-globin gene, as occurs in other active globin genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENES
KW  - PROTEINS
KW  - HEMOGLOBIN
KW  - CELLS
KW  - CHROMOSOMES
KW  - GENETIC regulation
KW  - GENE expression
KW  - BONE marrow cells
N1  - Accession Number: 13774332; Shj-Xian Cao 1 Schecuter, Alan N. 1; Affiliation:  1: Laboratory of Chemical Biology, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland; Source Info: 5/2/88, Vol. 173 Issue 3, p517; Subject Term: GENES; Subject Term: PROTEINS; Subject Term: HEMOGLOBIN; Subject Term: CELLS; Subject Term: CHROMOSOMES; Subject Term: GENETIC regulation; Subject Term: GENE expression; Subject Term: BONE marrow cells; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaye, Walter H.
AU  - Gwirtsman, Harry E.
AU  - Obarzanek, Eva
AU  - George, David T.
T1  - Relative importance of calorie intake needed to gain weight and level of physical activity in anorexia nervosa.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/06//
VL  - 47
IS  - 6
M3  - Article
SP  - 989
EP  - 994
SN  - 00029165
AB  - We assessed whether level of physical activity of anorexia nervosa patients could influence caloric consumption needed to gain weight during hospitalization. Seventy-three percent of patients with anorexia nervosa had higher levels of motor activity than did healthy female volunteers. Anorectics required 8301 ± 2272 kcal (mean ± SD) to gain 1 kg body wt. Activity levels and caloric consumption needed to gain I kg were significantly correlated; the most active patients needed to consume more calories to gain weight. A median split of anorectic patients by level of activity showed that the group with lower activity levels gained 1 kg every 5.1 ± 1.2 d, whereas the group with higher activity levels gained 1 kg every 7.2 ± 1.9 d. These data suggest that the rate of weight gain can be accelerated, and the cost of hospitalization decreased, by restricting exercise in anorectics during refeeding. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Anorexia nervosa
KW  - Calorie
KW  - Weight gain
KW  - Hospital care
KW  - Nutrition research
KW  - Anorexia nervosa
KW  - caloric utilization
KW  - motor activity
KW  - weight gain
N1  - Accession Number: 91710585; Kaye, Walter H. 1; Gwirtsman, Harry E. 2; Obarzanek, Eva 3; George, David T. 4; Affiliations: 1: Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA; 2: Neuropsychiatric Institute, Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, CA; 3: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD; 4: National Institute of Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD; Issue Info: Jun1988, Vol. 47 Issue 6, p989; Thesaurus Term: RESEARCH; Subject Term: Anorexia nervosa; Subject Term: Calorie; Subject Term: Weight gain; Subject Term: Hospital care; Subject Term: Nutrition research; Author-Supplied Keyword: Anorexia nervosa; Author-Supplied Keyword: caloric utilization; Author-Supplied Keyword: motor activity; Author-Supplied Keyword: weight gain; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Klebanoff, Mark A.
T1  - Short Interpregnancy Interval and the Risk of Low Birthweight.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/06//
VL  - 78
IS  - 6
M3  - Article
SP  - 667
EP  - 670
PB  - American Public Health Association
SN  - 00900036
AB  - The effect of interpregnancy interval on the birthweight of the subsequent child was investigated in a cohort of 5,938 women who registered for two consecutive pregnancies in the Collaborative Perinatal Project, Mean birthweight increased from 3,101 grams for intervals of <3 months to 3,193 grams for intervals of 15–17,9 months and remained stable thereafter (p for trend = 0,006), However, women with shorter intervals were younger, lighter weight, and less educated at the beginning of the first pregnancy than were women with longer intervals; the birthweight of their previous child was lower, and they were of marginally lower socioeconomic status. Adjustment for confounders reduced the maximum difference in mean birthweight by interval length from 92 to 39 grams, and blunted the trend for lower birthweights with shorter intervals (p = 0,45), Similarly, adjustment reduced the increased risk of low birthweight among women with the shortest intervals from 52 per cent to 12 per cent. We conclude that a short interpregnancy interval is primarily a marker for a woman who is otherwise at high risk, and that modification of this interval alone may be unlikely to have a major impact on low birthweight. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANCY
KW  - LOW birth weight
KW  - DELIVERY (Obstetrics)
KW  - CHILDBIRTH
KW  - MATERNAL health services
KW  - FETAL growth retardation
KW  - SOCIODEMOGRAPHIC factors
KW  - NEONATAL intensive care
KW  - CONCEPTION
N1  - Accession Number: 4693174; Klebanoff, Mark A. 1; Affiliation:  1: Epidemiology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Landow building, Rm 8A04, Bethesda, MD 20892; Source Info: Jun88, Vol. 78 Issue 6, p667; Subject Term: PREGNANCY; Subject Term: LOW birth weight; Subject Term: DELIVERY (Obstetrics); Subject Term: CHILDBIRTH; Subject Term: MATERNAL health services; Subject Term: FETAL growth retardation; Subject Term: SOCIODEMOGRAPHIC factors; Subject Term: NEONATAL intensive care; Subject Term: CONCEPTION; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dannenberg, Andrew L.
AU  - Garrison, Robert J.
AU  - Kannel, William B.
T1  - Incidence of Hypertension in the Framingham Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/06//
VL  - 78
IS  - 6
M3  - Article
SP  - 676
EP  - 679
PB  - American Public Health Association
SN  - 00900036
AB  - Incidence and trends in incidence of definite hypertension ere analyzed based on 30 years follow-up of 5.209 subjects in the Framingham Heart Study cohort. Based on pooling of 15 two-year periods, hypertension incidence per biennium increased with age in men from 3.3 percent at ages 30–39 to 6.2 percent at ages 70–79, and in women from 1.5 per cent at ages 30–39 to 8.6 per cent at ages 70–79. No consistent trend in incidence rates was evident for either sex from the 1950s through the 1970s. The proportion of hypertensive subjects receiving antihypertensive medication has increased since 1954–58 and exceeded 80 per cent for both men and women ages 60–89 years in 1979–81. Incidence data presented in this report may serve as a baseline for assessing the impact of future public health efforts in the primary prevention of hypertension. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYPERTENSION
KW  - CARDIOVASCULAR diseases
KW  - BLOOD pressure
KW  - BLOOD circulation disorders
KW  - MEDICAL care
KW  - PUBLIC health
KW  - HEALTH education
KW  - HUMAN services
KW  - FRAMINGHAM Heart Study (Organization)
N1  - Accession Number: 4693241; Dannenberg, Andrew L. 1 Garrison, Robert J. 1 Kannel, William B. 2; Affiliation:  1: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda  2: Section of Preventive Medicine and Epidemiology, Boston University, School of Medicine; Source Info: Jun88, Vol. 78 Issue 6, p676; Subject Term: HYPERTENSION; Subject Term: CARDIOVASCULAR diseases; Subject Term: BLOOD pressure; Subject Term: BLOOD circulation disorders; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: HEALTH education; Subject Term: HUMAN services; Company/Entity: FRAMINGHAM Heart Study (Organization); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donahue, Richard P.
AU  - Abbott, Robert D.
AU  - Reed, Dwayne M.
AU  - Yano, Katsuhiko
T1  - Physical Activity and Coronary Heart Disease in Middle-Aged and Elderly Men: The Honolulu Heart Program.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/06//
VL  - 78
IS  - 6
M3  - Article
SP  - 683
EP  - 685
PB  - American Public Health Association
SN  - 00900036
AB  - The relationship of physical activity to the development of definite coronary heart disease was examined separately in middle-aged (45–64 years) and elderly men (65–69 years) participating in the Honolulu Heart Program. After 12 years of follow-up, results indicate that increased levels of physical activity reported at study entry were inversely related to the risk of definite coronary heart disease in both age groups. In particular, among those aged 45 to 64 years, the rate of definite coronary heart disease in men who led active life styles was 30 per cent lower than the rate experienced by those who were less active (relative risk, 0.69; 95% confidence interval, 0.53, 0.88). In those older than 64 years, the rate of definite coronary heart disease in active men was less than half the rate experienced by those who led more sedentary life styles (relative risk, 0.43; 95% Cl, 0.19, 0.99). These results continued to hold up when controlling for several cardiovascular risk factors and potentially confounding variables, supporting earlier observations that physical activity is beneficial in middle-age, and further suggesting that benefits may extend to the elderly male population as well. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORONARY heart disease
KW  - CARDIOVASCULAR diseases
KW  - PHYSICAL fitness
KW  - MIDDLE-aged persons
KW  - OLDER men
KW  - DISEASES -- Risk factors
KW  - HEALTH promotion
KW  - HONOLULU (Hawaii)
KW  - HAWAII
N1  - Accession Number: 4693419; Donahue, Richard P. 1 Abbott, Robert D. 2 Reed, Dwayne M. 3 Yano, Katsuhiko 4; Affiliation:  1: Department of Medicine, Division of General Medicine and Primary Care, University of Massachusetts Medical Center, 55 Lake Avenue, North Worcester, MA 01655  2: Statistical Resource Section, National Heart, Lung, and Blood Institute, Bethesda, MD  3: Honolulu Epidemiology Research Section, NHLBL Honolulu, HI 96817  4: Honolulu Heart Program, Kuakini Medical Center, Honolulu; Source Info: Jun88, Vol. 78 Issue 6, p683; Subject Term: CORONARY heart disease; Subject Term: CARDIOVASCULAR diseases; Subject Term: PHYSICAL fitness; Subject Term: MIDDLE-aged persons; Subject Term: OLDER men; Subject Term: DISEASES -- Risk factors; Subject Term: HEALTH promotion; Subject Term: HONOLULU (Hawaii); Subject Term: HAWAII; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Furue, Masutaka
AU  - Gaspari, Anthony A.
AU  - Katz, Stephen I.
T1  - The Effect of Cyclosporin A on Epidermal Cells. II. Cyclosporin A Inhibits Proliferation of Normal and Transformed Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1988/06//
VL  - 90
IS  - 6
M3  - Article
SP  - 796
EP  - 800
SN  - 0022202X
AB  - Cylcosporin A (CSA) is a potent immunosuppressive drug that inhibits the proliferation of activated T cells by blocking the production of interleukin 2. Recent studies have demonstrated that CSA also inhibits the proliferation of neoplastic cells of hematopoietic and nonhematopoietic origin. CSA has also been reported to be effective in the treatment of psoriasis, which is characterized by epidermal hyperproliferation. As so many of the therapeutically effective agents in psoriasis are antiproliferative, we sought to determine whether CSA affects the proliferation of keratinocytes. We studied the effect of CSA on the proliferation of normal and transformed keratinocytes and demonstrated that CSA inhibits DNA synthesis and proliferation of keratinocytes. CSA also inhibits DNA synthesis of other neoplastic cells of hematopoietic and nonhematopoietic origin. These findings indicate the CSA inhibits the proliferation of various cell types. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYCLOSPORINE
KW  - LANGERHANS cells
KW  - KERATINOCYTES
KW  - T cells
KW  - INTERLEUKIN-2
KW  - IMMUNOSUPPRESSIVE agents
N1  - Accession Number: 12462009; Furue, Masutaka 1 Gaspari, Anthony A. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun88, Vol. 90 Issue 6, p796; Subject Term: CYCLOSPORINE; Subject Term: LANGERHANS cells; Subject Term: KERATINOCYTES; Subject Term: T cells; Subject Term: INTERLEUKIN-2; Subject Term: IMMUNOSUPPRESSIVE agents; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12462009
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12462009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Recalled Parent-Child Relations and Adult Personality.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1988/06//
VL  - 56
IS  - 2
M3  - Article
SP  - 417
EP  - 434
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Adult children's ratings of their parents' behaviors on the Parent-Child Relation Questionnaire 11 were correlated with self-reports and peer ratings of personality on the NEO Personality Inventory in a sample of 619 men and women aged 21 to 96. Individuals who reported that their parents were loving scored lower in neuroticism and higher in extraversion, openness to experience, agreeableness, and conscientiousness Individuals, especially men, who described their parents as casual rather than demanding were lower in extraversion and conscientiousness, but higher in openness. Parental attention (i.e. spoiling) was associated with extraversion and low agreeableness. Several of these correlations were replicated when peer ratings of personality were examined. However, all the associations were modest, and several alternative explanations suggest that the correlations may exaggerate the influence of these child rearing practices on adult personality Parental behaviors and attitudes seem to have less effect on broad dimensions of adult personality than traditionally supposed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PARENT & child
KW  - ADOLESCENT psychology
KW  - EXTRAVERSION
KW  - PERSONALITY
KW  - HUMAN behavior
KW  - INTERPERSONAL relations
N1  - Accession Number: 8970948; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH; Source Info: Jun88, Vol. 56 Issue 2, p417; Subject Term: PARENT & child; Subject Term: ADOLESCENT psychology; Subject Term: EXTRAVERSION; Subject Term: PERSONALITY; Subject Term: HUMAN behavior; Subject Term: INTERPERSONAL relations; Number of Pages: 18p; Document Type: Article
L3  - 10.1111/1467-6494.ep8970948
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr, Paul T.
T1  - Do Parental Influences Matter? A Reply to Halverson.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1988/06//
VL  - 56
IS  - 2
M3  - Article
SP  - 445
EP  - 449
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Halverson (1988) raises many objections to the retrospective method, but only some of them are applicable to our study (McCrae & Costa, 1988), further,Halverson fails to distinguish between random error and bias in retrospective data. We argue that retrospective accounts can provide one useful source of evidence when the probable effects of biases are taken into account. The small associations between recalled parent child relations and adult personality that we reported were probably exaggerated rather than masked by retrospective bias, we took this into account in reaching our conclusions. Rather than dismiss the method, psychologists should question the entrenched belief that child-rearing is a major determinant of adult personality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD psychology
KW  - PARENT & child
KW  - LONGITUDINAL method
KW  - SOCIAL science research
KW  - PSYCHOLOGISTS
KW  - CHILD rearing
N1  - Accession Number: 8970995; McCrae, Robert R. 1 Costa Jr, Paul T. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH; Source Info: Jun88, Vol. 56 Issue 2, p445; Subject Term: CHILD psychology; Subject Term: PARENT & child; Subject Term: LONGITUDINAL method; Subject Term: SOCIAL science research; Subject Term: PSYCHOLOGISTS; Subject Term: CHILD rearing; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1467-6494.ep8970995
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brookmever, Ron
AU  - Gail, Mitchell H.
T1  - A Method for Obtaining Short-Term Projections and Lower Bounds on the Size of the AIDS Epidemic.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1988/06//
VL  - 83
IS  - 402
M3  - Article
SP  - 301
SN  - 01621459
AB  - A methodology is proposed for obtaining short-term projections of the acquired immunodeficiency syndrome (AIDS) epidemic by projecting the number of cases from those already infected with the AIDS virus. This is a lower bound on the size of the AIDS epidemic, because even if future infections could be prevented, one could still anticipate this number of cases. The methodology is novel in that no assumptions are required about either the number of infected individuals in the population or the probability of an infected individual eventually developing AIDS. The methodology presupposes knowledge of the incubation distribution, however, among those destined to develop AIDS. Although the method does not account for new infections, it may produce accurate short-term projections because of the relatively long incubation period from infection to clinically diagnosed AIDS. The estimation procedure "back-calculates" from AIDS incidence data to numbers previously infected. The number of cases diagnosed in each calendar period has a multinomial distribution with cell probabilities that can be expressed as a convolution of the density of infection times and the incubation distribution. The problem is shown to reduce to estimating the size of a multinomial population. A simple EM algorithm is developed for obtaining maximum likelihood estimates when the density of infection times is parameterized as a step function. The methodology is applied to AIDS incidence data in the United States, to obtain short-term projections and an estimate of the minimum size of the epidemic by assuming no new infections in 1987 and after. The sensitivity of the projections to the assumed incubation distribution is investigated. It was found that short-term projections are not nearly as... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - FORECASTING
KW  - AIDS (Disease)
KW  - METHODOLOGY
KW  - COMMUNICABLE diseases
KW  - IMMUNOLOGICAL deficiency syndromes
KW  - EPIDEMIOLOGY
KW  - INFECTION
KW  - Epidemiology
KW  - Infectious diseases
KW  - Multinomial distribution.
N1  - Accession Number: 4608312; Brookmever, Ron 1; Gail, Mitchell H. 2; Affiliations: 1: Associate Professor, Department of Biostatistics, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.; 2: Head, Epidemiologic Methods Section, Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892.; Issue Info: Jun88, Vol. 83 Issue 402, p301; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: FORECASTING; Subject Term: AIDS (Disease); Subject Term: METHODOLOGY; Subject Term: COMMUNICABLE diseases; Subject Term: IMMUNOLOGICAL deficiency syndromes; Subject Term: EPIDEMIOLOGY; Subject Term: INFECTION; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Infectious diseases; Author-Supplied Keyword: Multinomial distribution.; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2006-05462-045
AN  - 2006-05462-045
AU  - Zahn, Theodore P.
T1  - Psychoneuroendocrinology in a nutshell.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/06//
VL  - 33
IS  - 6
SP  - 534
EP  - 535
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05462-045. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Neuroendocrinology; Physiology; Stress. Minor Descriptor: History. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Reviewed Item: Asterita, Mary F. The Physiology of Stress: With Special Reference to the Neuroendocrine System=New York: Human Sciences Press, 1985. 281 pp. $16.95 paperback; 1985. Page Count: 2. Issue Publication Date: Jun, 1988. 
AB  - Reviews the book, The Physiology of Stress: With Special Reference to the Neuroendocrine System by Mary F. Asterita (1985). The book begins and ends with short historical accounts of the influential contributions of Cannon and Selye and, to a lesser extent, the earlier contributions of Claude Bernard and the more recent ones of John Mason. Various concepts of stress were held by these authors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuroendocrine system
KW  - historical accounts
KW  - physiology
KW  - stress
KW  - 1988
KW  - Neuroendocrinology
KW  - Physiology
KW  - Stress
KW  - History
KW  - 1988
U2  - Asterita, Mary F. (1985); The Physiology of Stress: With Special Reference to the Neuroendocrine System; New York: Human Sciences Press, 1985. 281 pp. $16.95 paperback
DO  - 10.1037/025805
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - NELSON, PHILLIP G.
T1  - Early Behavioral Plasticity.
JO  - Science
JF  - Science
Y1  - 1988/06/03/
VL  - 240
IS  - 4857
M3  - Article
SP  - 1351
EP  - 1352
SN  - 00368075
N1  - Accession Number: 87460475; NELSON, PHILLIP G. 1; Affiliation:  1: Laboratory of Developmntal Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD 20892; Source Info: 6/3/1988, Vol. 240 Issue 4857, p1351; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ota, Akira
AU  - Wilson, Gaye Lynn
AU  - Leroith, Derek
T1  - Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two β subunits are derived from differences in glycosylation.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1988/06/15/
VL  - 174
IS  - 3
M3  - Article
SP  - 521
EP  - 530
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have characterized receptors for the insulin-like growth factor (IGF-I) on the mouse neuroblastoma cell line N18 as well as NG108, the hybrid cell line of N18 and rat glioma (C6). In this cell-free system, IGF-I and insulin stimulated the phosphorylation of 95-kDa and 105-kDa proteins. Using appropriate antibodies we were able to demonstrate that the IGF-I receptor β subunit has two subtypes of 95 kDa and 105 kDa. On the other hand, insulin receptor β subunit is a separate single 95-kDa protein. Enzymatic digestion of IGF-I receptor β subunit subtypes by glycopeptidase F resulted in similar molecular masses (84 kDa and 86 kDa) on SDS-PAGE, which suggests that the difference in molecular masses between two subtypes is attributable to the differences in N-linked complex-type carbohydrate chains on the extracellular domain of β subunits. This conclusion is further supported by peptides of similar molecular mass following staphylococcal V8 protease digestion. Analysis of IGF-I receptor β subunit subtypes in these cells may provide insights into the mechanism of action of IGF-I on neural tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOMATOMEDIN
KW  - NEUROBLASTOMA
KW  - GLIOMAS
KW  - INSULIN
KW  - PHOSPHORYLATION
KW  - NERVOUS system
N1  - Accession Number: 13795385; Ota, Akira 1 Wilson, Gaye Lynn 1 Leroith, Derek 1; Affiliation:  1: Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda; Source Info: 6/15/88, Vol. 174 Issue 3, p521; Subject Term: SOMATOMEDIN; Subject Term: NEUROBLASTOMA; Subject Term: GLIOMAS; Subject Term: INSULIN; Subject Term: PHOSPHORYLATION; Subject Term: NERVOUS system; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 119526819
T1  - Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin.
AU  - Kraemer, K H
AU  - DiGiovanna, J J
AU  - Moshell, A N
AU  - Tarone, R E
AU  - Peck, G L
Y1  - 1988/06/23/
N1  - Accession Number: 119526819. Language: English. Entry Date: 19880901. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Checklist Individual Strength (CIS). Grant Information: Z01 BC004517-31//Intramural NIH HHS/United States. NLM UID: 0255562. 
KW  - Xeroderma Pigmentosum -- Complications
KW  - Skin Neoplasms -- Prevention and Control
KW  - Tretinoin -- Administration and Dosage
KW  - Clinical Trials
KW  - Administration, Oral
KW  - Female
KW  - Tretinoin -- Therapeutic Use
KW  - Carcinoma, Squamous Cell -- Prevention and Control
KW  - Adolescence
KW  - Tretinoin -- Adverse Effects
KW  - Isotretinoin
KW  - Male
KW  - Prospective Studies
KW  - Adult
KW  - Child
KW  - Human
KW  - Carcinoma, Basal Cell -- Prevention and Control
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Checklists
SP  - 1633
EP  - 1637
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 318
IS  - 25
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - To confirm reports that skin cancer can be prevented with retinoids, we conducted a three-year controlled prospective study of oral isotretinoin (also called 13-cis retinoic acid) in five patients with xeroderma pigmentosum who had a history of multiple cutaneous basal-cell or squamous-cell carcinomas. Patients were treated with isotretinoin at a dosage of 2 mg per kilogram of body weight per day for two years and then followed for an additional year, without the drug. Before, during, and after treatment, biopsies of all suspicious lesions were performed, and skin cancers were surgically removed. The patients had a total of 121 tumors (mean, 24; range, 8 to 43) in the two-year interval before treatment. During two years of treatment with isotretinoin, there were 25 tumors (mean, 5; range, 3 to 9), with an average reduction in skin cancers of 63 percent (P = 0.019). After the drug was discontinued, the tumor frequency increased a mean of 8.5-fold (range, 2- to 19-fold) over the frequency during treatment (P = 0.007). Although all patients experienced mucocutaneous toxic effects, and triglyceride, liver-function, or skeletal abnormalities developed in some, high-dose oral isotretinoin was effective in the chemoprophylaxis of skin cancers in patients with xeroderma pigmentosum.
SN  - 0028-4793
AD  - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Md 20892
U2  - PMID: 3287161.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bornstein, Marc H.
T1  - The Perceptual World of the Infant.
JO  - American Scientist
JF  - American Scientist
Y1  - 1988/07//Jul/Aug88
VL  - 76
IS  - 4
M3  - Book Review
SP  - 395
SN  - 00030996
AB  - Reviews the books "Perceptual Development in Early Infancy: Problems and Issues," edited by Beryl E. McKenzie and Rose H. Day and "Perceptual Development in Infancy: The Minnesota Symposia on Child Psychology," edited by Albert Yonas.
KW  - McKenzie, Beryl
KW  - Day, Rose
KW  - Yonas, Albert
KW  - Perceptual Development in Early Infancy: Problems & Issues (Book)
N1  - Accession Number: 11802340; Bornstein, Marc H. 1; Affiliations: 1: National Institute of Child Health and Human Development, Bethesda, MD; Issue Info: Jul/Aug88, Vol. 76 Issue 4, p395; Reviews & Products: Perceptual Development in Early Infancy: Problems & Issues (Book); People: McKenzie, Beryl; People: Day, Rose; People: Yonas, Albert; Number of Pages: 1/2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Nagel, James E.
T1  - OUT-OF-DATE VIRUSES.
JO  - BioScience
JF  - BioScience
Y1  - 1988/07//Jul/Aug88
VL  - 38
IS  - 7
M3  - Book Review
SP  - 512
EP  - 512
SN  - 00063568
AB  - Reviews the book "Viruses, Immunity, and Immunodeficiency," edited by Andor Szentivany and Herman Friedman.
KW  - Viruses
KW  - Nonfiction
KW  - Viruses, Immunity & Immunodeficiency (Book)
N1  - Accession Number: 10113437; Nagel, James E. 1; Affiliations: 1: National Institutes of Health, National Institute on Aging Gerontology Research Center, Bethesda, MD 21224; Issue Info: Jul/Aug88, Vol. 38 Issue 7, p512; Thesaurus Term: Viruses; Subject Term: Nonfiction; Reviews & Products: Viruses, Immunity & Immunodeficiency (Book); Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 389
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Marcon, Luisa
AU  - Fritz, Mary E.
AU  - Kurman, Carole C.
AU  - Jensen, J. C.
AU  - Nelson, D. L.
T1  - Soluble Tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL).
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1988/07//
VL  - 73
IS  - 1
M3  - Article
SP  - 29
EP  - 33
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The T lymphocyte-derived lymphokine interleukin 2 and the cell-associated receptor for this molecule play major roles in the activation and regulation of the human immune response. An enzyme-linked immunosorbent assay has been developed to measure quantitatively a soluble form of one component of the human interleukin 2 receptor, namely the Tac peptide. In the present studies, soluble Tac peptide was measured in the urine of normal individuals (mean =92 U/ml), a level not significantly different (0.01 < P<0.05) from the corresponding serum concentrations (mean= 175). The urinary Tac peptide had a molecular weight of 40-45 kD by sodium dodecyl sulphatepolyacrylamide gel electrophoresis analysis and specifically bound interleukin 2. Elevated levels of urinary Tac peptide were found in four patients with adult T cell leukaemia who also had elevated serum levels of Tac peptide. Thus, urine may represent a valuable source of lymphokine-binding proteins that may serve as important markers of immunological activation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - LYMPHOKINES
KW  - URINE
KW  - INTERLEUKIN-2
KW  - LEUKEMIA
KW  - CANCER
KW  - 2
KW  - interleukin
KW  - peptide
KW  - receptor
KW  - Tac
N1  - Accession Number: 16173480; Marcon, Luisa 1 Fritz, Mary E. 1 Kurman, Carole C. 1 Jensen, J. C. 2 Nelson, D. L. 1; Affiliation:  1: Immunophysiology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.  2: Hoffman La Roche, Inc., Nutley, NJ, USA.; Source Info: Jul1988, Vol. 73 Issue 1, p29; Subject Term: T cells; Subject Term: LYMPHOKINES; Subject Term: URINE; Subject Term: INTERLEUKIN-2; Subject Term: LEUKEMIA; Subject Term: CANCER; Author-Supplied Keyword: 2; Author-Supplied Keyword: interleukin; Author-Supplied Keyword: peptide; Author-Supplied Keyword: receptor; Author-Supplied Keyword: Tac; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - ZAHAREVITZ, Daniel W.
AU  - NAPIER, Elizabeth A.
AU  - ANDERSON, Lawrence W.
AU  - STRONG, John M.
AU  - CYSYK, Richard L.
T1  - Stimulation of uracil nucleotide synthesis in mouse liver, intestine and kidney by ammonium chloride infusion.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1988/07//7/1/88
VL  - 175
IS  - 1
M3  - Article
SP  - 193
EP  - 198
PB  - Wiley-Blackwell
SN  - 00142956
AB  - De novo pyrimidine synthesis was studied in mouse liver, intestine, and kidney by intraperitoneal infusion of 15NH4Cl and analysis of 15N incorporation into uracil nucleotide pools. When the dose of a 1-h infusion of 15NH4Cl was increased from 50 μmol to 250 μmol the fraction of the total uracil nucleotide pool formed by de novo synthesis increased 4.0-fold in liver to 8.4% and 2.3-fold in intestine to 13.7%. The increase in intestine was independent of the increase in liver as evidenced by the lack of correlation between the increase observed in the intestine and liver of the same animal and the different distributions of label in the uracil ring nitrogens. A 2.4-fold increase in newly formed uracil nucleotides was observed in kidney when the infusion dose was raised from 150 μmol to 250 μmol. The increase in kidney was correlated with the increase in liver in the same animal and the distribution of label in the uracil ring nitrogens was similar to the distribution in liver. These results suggest that the increase in newly formed uracil nucleotides in intestine is due to increased de novo synthesis of pyrimidines in the intestine, while the increase in the kidney is due to increased salvage synthesis of uracil nucleotides from uridine synthesized in the liver and output to the circulation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 120460854; ZAHAREVITZ, Daniel W. 1 NAPIER, Elizabeth A. 1 ANDERSON, Lawrence W. 1 STRONG, John M. 1 CYSYK, Richard L. 1; Affiliation:  1: Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD.; Source Info: 7/1/88, Vol. 175 Issue 1, p193; Number of Pages: 6p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Saxena, R. K.
AU  - Saxena, Q. B.
AU  - Adler, W. H.
T1  - Lectin-induced cytotoxic activity in spleen cells from young and old mice. Age-related changes in types of effector cells, lymphokine production and response.
JO  - Immunology
JF  - Immunology
Y1  - 1988/07//
VL  - 64
IS  - 3
M3  - Article
SP  - 457
EP  - 461
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Concanavalin A (Con A)-induced cytotoxic activity, interferon (IFN) and interleukin-2 (IL-2) levels in cultures of spleen cells from young (2-3 months) and old (22-24 months) C578L/6 female mice were studied. Con A-activated spleen cells from old mice attained significantly higher cytotoxic activity compared with activated spleen cells from young mice. Activated spleen cells from old and young mice showed differences in their ability to lyse different types of target cells. Both could lyse P 815 cells, neither could lyse K562 cells, and only activated cells from old mice could lyse EL-4 cells. Cytotoxic spleen cells from the old mice were more sensitive to anti-asialo-GM-l and anti-Lyt-2.2 plus complement (C) treatment. While levels of IL-2 produced by spleen cells from young mice were higher, the addition of exogenous IL-2 had no effect on cytotoxic activity of the spleen cells from old mice. Exogenous IL-2, however, could lower cytotoxic activity of Con A-activated spleen cells from young mice. Activated spleen cells from old mice generated higher levels of IFN-γ while the addition of an anti-IFN-γ antibody boosted the level of cytotoxicity by Con A-activated spleen cells from young mice. These results suggest that IFN-γ may act as a feedback inhibitory signal regulating the levels of cytotoxicity induced in spleen cells from young mice in response to Con A. The cytotoxic activity generated in Con A-activated spleen cells from old mice reflects a defect in this feed-back regulation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTINEOPLASTIC agents
KW  - ANTIVIRAL agents
KW  - LYMPHOKINES
KW  - INTERLEUKIN-2
KW  - T cells
KW  - SPLEEN
N1  - Accession Number: 14008620; Saxena, R. K. 1 Saxena, Q. B. 1 Adler, W. H. 2; Affiliation:  1: School of Life Sciences, Jawaharlal Nehru University, New Delhi.  2: Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland U.S.A.; Source Info: Jul88, Vol. 64 Issue 3, p457; Subject Term: ANTINEOPLASTIC agents; Subject Term: ANTIVIRAL agents; Subject Term: LYMPHOKINES; Subject Term: INTERLEUKIN-2; Subject Term: T cells; Subject Term: SPLEEN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104760039
T1  - Chronic fungal sinusitis in apparently normal hosts.
AU  - Washburn, R G
AU  - Kennedy, D W
AU  - Begley, M G
AU  - Henderson, D K
AU  - Bennett, J E
Y1  - 1988/07//1988 Jul
N1  - Accession Number: 104760039. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Mycoses -- Diagnosis
KW  - Mycoses -- Pathology
KW  - Mycoses -- Radiography
KW  - Sinusitis -- Diagnosis
KW  - Sinusitis -- Pathology
KW  - Sinusitis -- Radiography
KW  - Adult
KW  - Chronic Disease
KW  - Diagnosis, Differential
KW  - Female
KW  - Male
KW  - Paranasal Sinuses -- Anatomy and Histology
KW  - Paranasal Sinuses -- Pathology
KW  - Paranasal Sinuses -- Radiography
KW  - Tomography, X-Ray Computed
SP  - 231
EP  - 247
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 67
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Several fungal species are capable of causing either noninvasive fungal sinusitis or invasive disease characterized by erosion into mucosa, submucosa, bone, and deeper contiguous structures. The diagnosis of invasive infection becomes firmly established only after histologic demonstration of hyphae within these areas. Computerized tomography and magnetic resonance imaging can assist in distinguishing between invasive and noninvasive disease by outlining bone and adjacent structures. The 2 forms of chronic fungal sinusitis mandate different therapeutic approaches. While patients with noninvasive infection require only surgical removal of hyphal masses and the reestablishment of sinus drainage for a successful outcome, invasive infection necessitates not only thorough surgical debridement of abnormal tissues but may also require prolonged antifungal chemotherapy. All patients require long-term follow-up. Even the combined approach has sometimes proven disappointing during long-term follow-up of disease, rendering investigational therapy appropriate in some patients.
SN  - 0025-7974
AD  - Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
U2  - PMID: 3393078.
DO  - 10.1097/00005792-198807000-00004
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Carter, J W
AU  - Perry, D J
AU  - Tingley, D E
T1  - How to automate a service desk using dBASE III PLUS
JO  - Online
JF  - Online
Y1  - 1988/07//
VL  - 12
IS  - 4
M3  - Article
SP  - 120
EP  - 124
SN  - 01465422
AB  - This article describes a database created on dBASE III PLUS containing frequently requested information from the National Cancer Institute's International Cancer Research Data Bank (ICRDB) service desk. Design and use of the database are discussed. An evaluation is also provided.
KW  - DATABASES
KW  - Automation
KW  - Cancer
KW  - Computer programs
N1  - Accession Number: ISTA2302614; Carter, J W 1; Perry, D J; Tingley, D E; Affiliations: 1 : National Cancer Institute Bethesda, MD;  Source Info: Jul 1988, Vol. 12 Issue 4, p120; Note: Update Code: 2300; Subject Term: DATABASES; Author-Supplied Keyword: Automation; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Computer programs; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
T1  - Living with AIDS and HIV (Book).
AU  - Baron, David A.
JO  - Stress Medicine
JF  - Stress Medicine
Y1  - 1988/07//Jul/Sep88
VL  - 4
IS  - 3
SP  - 179
EP  - 179
SN  - 07488386
N1  - Accession Number: 12056201; Author: Baron, David A.: 1 ; Author Affiliation: 1 National Institute of Mental Health, Bethesda, USA; No. of Pages: 1/3; Language: English; Publication Type: Book Review; Update Code: 20040127
N2  - Reviews the book "Living With AIDS and HIV," by David Miller.
KW  - *HIV infections
KW  - *AIDS (Disease)
KW  - NONFICTION -- Reviews
KW  - NONFICTION
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2006-05463-009
AN  - 2006-05463-009
AU  - Shah, Saleem A.
T1  - A Critique of Legal Psychology.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/07//
VL  - 33
IS  - 7
SP  - 586
EP  - 588
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05463-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; Antisocial and Violent Behavior Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Adjudication; Forensic Psychology; Laws; Legal Processes. Minor Descriptor: Criminal Justice. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Reviewed Item: King, Michael. Psychology in and Out of Court: A Critical Examination of Legal Psychology=Oxford, England: Pergamon Press, 1986. 119 pp. $19.75; 1986. References Available: Y. Page Count: 3. Issue Publication Date: Jul, 1988. 
AB  - Reviews the book, Psychology in and Out of Court: A Critical Examination of Legal Psychology by Michael King (see record [rid]1987-97211-000[/rid]). There is a fairly long history of research and related interests in the law, legal systems, and processes by psychologists from a variety of specialties. In this concise book, King provides a fairly scathing critique of what he refers to as 'legal psychology,' from the perspective of 'an English lawyer qualified in psychology.' The author indicates that he plans to make a fairly disciplined use of terms such as the law and legal processes in addressing the topics of concern. Thus, when talking about the law, he is actually referring to the legal system, the criminal justice system (which is concerned with administration of the criminal law), and legal processes. Unfortunately, the value of this book is seriously compromised by several problemmatic features. The author seems to have many axes to grind. This quality is as persistent as it is also striking. There is a penchant for overstatements, extravagant rhetoric, sweeping generalizations, and unqualified and unsubstantiated assertions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - legal psychology
KW  - criminal justice system
KW  - criminal law
KW  - legal processes
KW  - courts
KW  - 1988
KW  - Adjudication
KW  - Forensic Psychology
KW  - Laws
KW  - Legal Processes
KW  - Criminal Justice
KW  - 1988
U2  - King, Michael. (1986); Psychology in and Out of Court: A Critical Examination of Legal Psychology; Oxford, England: Pergamon Press, 1986. 119 pp. $19.75; 0-08-026798-X.
DO  - 10.1037/030463
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - STAUDT, LOUIS M.
AU  - CLERC, ROGER G.
AU  - SINGH, HARINDER
AU  - LEBOWITZ, JONATHAN H.
AU  - SHARP, PHILLIP A.
AU  - BALTIMORE, DAVID
T1  - Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif.
JO  - Science
JF  - Science
Y1  - 1988/07/29/
VL  - 241
IS  - 4865
M3  - Article
SP  - 577
EP  - 580
SN  - 00368075
AB  - An octamer DNA sequence plays a critical role in directing transcription of immunoglobulin genes in B lymphocytes. A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in λgt11 phage to derive molecular cDNA clones representing a putative B lymphocyte-specific octamer binding protein. The plaques were screened with DNA containing four copies of the octamer sequence and positive phage recombinants were identified. The fusion protein produced on inducing a lysogen ofone phage bound to a monomeric octamer probe. The cDNA insert from this phage hybridized to messenger RNA found in B lymphocytes, but not in most other cells. Thus, this cDNA derives from a gene (oct-2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell-specific transcription factor exists and its amount is controlled through messenger RNA availability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87460509; STAUDT, LOUIS M. 1,2,3 CLERC, ROGER G. 4 SINGH, HARINDER 4 LEBOWITZ, JONATHAN H. 4 SHARP, PHILLIP A. 4 BALTIMORE, DAVID 1,2; Affiliation:  1: Whitehead Institute for Biomedical Research, Cambridge, MA 02142  2: Department of Biology, Massachusetts Institute ofTechnologv, Cambridge, MA 02139  3: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892  4: Center for Cancer Research and Departmnent of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Source Info: 7/29/1988, Vol. 241 Issue 4865, p577; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dimitrov, Nikolay V.
AU  - Meyer, Cheryl
AU  - Ullrey, Duane E.
AU  - Chenoweth, Wanda
AU  - Michelakis, Andrew
AU  - Malone, Winfred
AU  - Boone, Charles
AU  - Fink, Gregory
T1  - Bioavailability of β-carotene in humans.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/08//
VL  - 48
IS  - 2
M3  - Article
SP  - 298
EP  - 304
SN  - 00029165
AB  - Normal healthy volunteers were studied after they ingested various β- carotene doses. Daily administration of 15 or 45 mg β-carotene resulted in significant increase in plasma β-carotene levels. The extent of increase and the pattern of plasma β-carotene levels showed substantial interindividual variation. Absorption of β-carotene was affected by dietary fat concentration. Individuals placed on a high-fat diet showed significant increases in plasma β-carotene as compared with those placed on a low-fat diet. Pharmacological doses of β-carotene (45 and 90 mg) were used in intermittent schedules (5-6 d intervals) without altering the steady state of β-carotene plasma levels. Yellowing of the skin occasionally occurred during daily dosing with 45 mg β-carotene without evidence of toxicity. The observed individual variation in bioavailability of β-carotene raises questions regarding clinical use of this micronutrient. It appears that determination of target plasma β-carotene concentrations is essential for effective use of this compound in prevention or treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bioavailability
KW  - HEALTH
KW  - Toxicity testing
KW  - Medical personnel
KW  - Volunteers
KW  - Blood plasma
KW  - β-carotene
KW  - bioavailability
KW  - high-fat diet
KW  - humans
KW  - low-fat diet
KW  - target concentration
N1  - Accession Number: 91711289; Dimitrov, Nikolay V. 1,2,3; Meyer, Cheryl 1,2,3; Ullrey, Duane E. 1,2,3; Chenoweth, Wanda 1,2,3; Michelakis, Andrew 1,2,3; Malone, Winfred 1,2,3; Boone, Charles 1,2,3; Fink, Gregory 1,2,3; Affiliations: 1: Department of Medicine, Animal Science, Food Science and Human Nutrition, Michigan State University, East Lansing, MI; 2: Department of Pharmacology and Toxicology, Animal Science, Food Science and Human Nutrition, Michigan State University, East Lansing, MI; 3: Chemoprevention Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; Issue Info: Aug1988, Vol. 48 Issue 2, p298; Thesaurus Term: Bioavailability; Thesaurus Term: HEALTH; Thesaurus Term: Toxicity testing; Subject Term: Medical personnel; Subject Term: Volunteers; Subject Term: Blood plasma; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: bioavailability; Author-Supplied Keyword: high-fat diet; Author-Supplied Keyword: humans; Author-Supplied Keyword: low-fat diet; Author-Supplied Keyword: target concentration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Harper, John R.
AU  - Greenhalgh, David A.
AU  - Yuspa, Stuart H.
T1  - Expression of Transfected DNA by Primary Murine Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1988/08//
VL  - 91
IS  - 2
M3  - Article
SP  - 150
EP  - 153
SN  - 0022202X
AB  - Primary murine keratinocytes can be maintained in culture for extended periods in a proliferative, basal cell state under conditions of reduced extracellular Ca2+ In response to increased Ca2++ concentrations, the cells undergo a well-defined program of terminal differentiation, thus serving as a convenient model in which to study the genes involved in regulating this and possibly other differentiation cascades by DNA- mediated gene transfer. However, because of their sensitivity to increased Ca2++ concentrations, the introduction of exogenous genomic DNA into primary keratinocytes by conventional methods is problematic. We have optimized the calcium phosphate DNA transfection procedure by introducing conditions that reduce the potency of Ca2+ as a differentiation signal. Primary epidermal cells were transfected with pSV2CAT, a plasmid that codes for the enzyme chloramphenicol acetyltransferase CAT. Enzyme activity was measured in cell extracts under varying transfection conditions. When the K+ concentration of the medium used for transfection by calcium phosphate precipitation is reduced from 6.5 to 0.01 mM, CAT activity following transfection increases 2-3 times. Exposure to the DNA precipitate for 2 - 4 h is optimal. By the use of fibroblast conditioned medium following transfection, enzyme activity can be detected in cell extracts for at least 21 d, suggesting that the exogenous gene is integrated. The low K++/Ca2+ transfection method is more effective than SrCl2 used as an alternative for CaC12 in Ca2+ sensitive cells. Low K+ medium enhances cell survival for Ca2+ mediated transfection but also appears to have a beneficial effect on DNA uptake or expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - KERATINOCYTES
KW  - CELLS
KW  - GENETIC transformation
KW  - CALCIUM
KW  - ENZYMES
N1  - Accession Number: 12464396; Harper, John R. 1 Greenhalgh, David A. 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug88, Vol. 91 Issue 2, p150; Subject Term: DNA; Subject Term: KERATINOCYTES; Subject Term: CELLS; Subject Term: GENETIC transformation; Subject Term: CALCIUM; Subject Term: ENZYMES; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12464396
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05464-038
AN  - 2006-05464-038
AU  - Chiueh, Chuang C.
T1  - Progress in Histochemistry.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/08//
VL  - 33
IS  - 8
SP  - 702
EP  - 703
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05464-038. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Chiueh, Chuang C.; Clinical Brain Imaging Section, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Histology; Neural Development; Neurochemistry; Neurons; Histochemistry. Minor Descriptor: Amino Acids; Central Nervous System; Nervous System; Neuropeptides. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Reviewed Item: Panula, Pertti (Ed); Päivärinta, Heikki (Ed); Soinila, Seppo (Ed). Neurohistochemistry: Modern Methods and Applications=New York: Liss, 1986. 690 pp. $158.00; 1986. Page Count: 2. Issue Publication Date: Aug, 1988. 
AB  - Reviews the book, Neurohistochemistry: Modern Methods and Applications by Pertti Panula, Heikki Päivärinta, and Seppo Soinila (Eds.) (see record [rid]1986-97935-000[/rid]). This volume summarizes the present state of knowledge concerning newly developed histochemical techniques, as well as their applications on studies of neuronal differentiation. Most of the new information provided here about the distribution of monoaminergic systems, putative amino acid nervous systems, and a coexistence of neuropeptides in the peripheral and central nervous system is not covered in classical textbooks of neuroanatomy. In conclusion, the editors have established a new and exciting direction for neurochemical research, neuron culture for brain transplantation, and chemical brain imaging in both basic and clinical research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - histochemistry
KW  - neuronal differentiation
KW  - monoaminergic systems
KW  - nervous systems
KW  - neuropeptides
KW  - 1988
KW  - Histology
KW  - Neural Development
KW  - Neurochemistry
KW  - Neurons
KW  - Histochemistry
KW  - Amino Acids
KW  - Central Nervous System
KW  - Nervous System
KW  - Neuropeptides
KW  - 1988
U2  - Panula, Pertti (Ed); Päivärinta, Heikki (Ed); Soinila, Seppo (Ed). (1986); Neurohistochemistry: Modern Methods and Applications; New York: Liss, 1986. 690 pp. $158.00; 0-8451-2718-7.
DO  - 10.1037/025899
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05464-039
AN  - 2006-05464-039
AU  - Zahn-Waxier, Carolyn
T1  - Depression: Born or Bred in Children?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/08//
VL  - 33
IS  - 8
SP  - 703
EP  - 703
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05464-039. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn-Waxier, Carolyn; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Infant Development; Major Depression; Mother Child Relations; Mothers. Minor Descriptor: Experimental Design. Classification: Affective Disorders (3211). Population: Human (10). Reviewed Item: Tronick, Edward Z. (Ed); Field, Tiffany (Ed). Maternal Depression and Infant Disturbance=San Francisco: Jossey-Bass, 1986. 87 pp. $12.95; 1986. Page Count: 1. Issue Publication Date: Aug, 1988. 
AB  - Reviews the book, Maternal Depression and Infant Disturbance by Edward Z. Tronick and Tiffany Field (Eds.) (1986). Many mothers experience depression, a condition that cannot help but have a significant impact on relationships with others. The resulting problems for mothers and their young children are considered here. This book identifies methodological problems in existing research (including studies described in this volume) and provides valuable suggestions for new research strategies and designs. These include better measures of functional impairment and depression in mothers and of disorder in children. Some chapters, though well written, are too brief to evaluate the procedures, statistical analyses, and results obtained. Because this is such a new research area, relying sometimes on findings from studies not originally designed to examine maternal depression and infant disturbance, there are inevitable shortcomings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - maternal depression
KW  - infant disturbances
KW  - research strategies
KW  - research designs
KW  - 1988
KW  - Infant Development
KW  - Major Depression
KW  - Mother Child Relations
KW  - Mothers
KW  - Experimental Design
KW  - 1988
U2  - Tronick, Edward Z. (Ed); Field, Tiffany (Ed). (1986); Maternal Depression and Infant Disturbance; San Francisco: Jossey-Bass, 1986. 87 pp. $12.95; 1-55542-997-1 (Paperback).
DO  - 10.1037/025900
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Gentile, Fabrizio
AU  - Raptis, Anastassios
AU  - Knipling, Leslie G.
AU  - Wolff, J.
T1  - <em>Bordetella pertussis</em> adenylate cyclase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1988/08/15/
VL  - 175
IS  - 3
M3  - Article
SP  - 447
EP  - 453
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Exposure of Chinese hamster ovary, mouse adrenal cortex tumor (Y-l), THP-1 and U-937 cells and human erythrocytes to adenylate-cyclase-containing urea extracts of Bordetella pertussis (strain 114) organisms promotes the formation of large concentrations of intracellular cAMP. Accumulation is dependent on dose and temperature, with significant accumulation occurring at 4°C, and is virtually instantaneous, with a doubling at 1 min. There is an absolute Ca2+ requirement but external caimodulin (the activator of cyclase activity) has no effect except in erythrocytes and U-937 cells, where it reduces cAMP accumulation. However, calmodulin antagonists inhibit cAMP accumulation. In Y-I adrenal cells the urea-extract adenylate cyclase stimulates steroidogenesis. Anti-(B. pertussis) antibodies inhibit cyclase activity and prevent further cAMP accumulation after 10 min in cells previously exposed to urea extract. The same effect is obtained by washing. This suggests that a portion of the cyclase is associated with cells in a form not accessible to antibody or washing but accessible to substrate, which we interpret as internalized enzyme with a short lifetime. Continuing cAMP accumulation thus appears to need a continuing source of external cyclase. lnhibitors of the effect of diphtheria toxin, such as NH4Cl, methylamine, chloroquin or monensin, have no inhibitory effect on the accumulation of intracelluar cAMP promoted by the internalized adenylate cyclase of urea extracts of B. pertussis organisms. We conclude that entry of the cyclase into cells is not by receptor-mediated endocytosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BORDETELLA pertussis
KW  - ADENYLATE cyclase
KW  - CELLS
KW  - HAMSTERS
KW  - ERYTHROCYTES
KW  - ADENYLIC acid
N1  - Accession Number: 13791229; Gentile, Fabrizio 1 Raptis, Anastassios 1 Knipling, Leslie G. 1 Wolff, J. 1; Affiliation:  1: National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda; Source Info: 8/15/88, Vol. 175 Issue 3, p447; Subject Term: BORDETELLA pertussis; Subject Term: ADENYLATE cyclase; Subject Term: CELLS; Subject Term: HAMSTERS; Subject Term: ERYTHROCYTES; Subject Term: ADENYLIC acid; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Micozzi, Marc S.
AU  - Albanes, Demetrius
T1  - Three limitations of the body mass index.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/09//
VL  - 48
IS  - 3
M3  - Letter to the Editor
SP  - 691
EP  - 692
SN  - 00029165
AB  - A letter to the editor is presented in response to the article "Three limitations of the body mass index" by Stanley M. Garn, Wiliam R. Leonard and Victor M. Hawthorne in the July 1986 issue.
KW  - Body mass index
KW  - Body weight
KW  - Fat
N1  - Accession Number: 91711340; Micozzi, Marc S. 1; Albanes, Demetrius 2; Affiliations: 1: Armed Forces Institute of Pathology, Washington, DC 20306; 2: National Cancer Institute, Bethesda, MD 20892-4200; Issue Info: Sep1988, Vol. 48 Issue 3, p691; Subject Term: Body mass index; Subject Term: Body weight; Subject Term: Fat; Number of Pages: 2p; Document Type: Letter to the Editor
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Butrum, Ritva R.
AU  - Clifford, Carolyn K.
AU  - Lanza, Elaine
T1  - NCI dietary guidelines: rationale.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/09//
VL  - 48
IS  - 3
M3  - Article
SP  - 888
EP  - 895
SN  - 00029165
AB  - The National Cancer Institute (NCI) believes that the potential for dietary changes to reduce the risk of cancer is considerable and that the existing scientific data provide evidence that is sufficiently consistent to warrant prudent interim dietary guidelines that will promote good health and reduce the risk of some types of cancer. Six interim dietary guidelines and their scientific rationale are discussed herein. The evidence presented for the scientific rationale is based on the 1982 National Academy of Sciences Committee report Diet, Nutrition and Cancer and NCI's own scientific reviews that link long-term dietary patterns with cancer risk. These guidelines to the American public are consistent with other dietary recommendations from the US departments of Agriculture and Health and Human Services, the American Cancer Society, and the American Heart Association. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Nutrition
KW  - Diet
KW  - Cancer -- Risk factors
KW  - Guidelines
KW  - cancer
KW  - nutrition
KW  - National Cancer Institute (U.S.)
KW  - National Academy of Sciences (U.S.)
KW  - American Cancer Society Inc.
KW  - American Heart Association
N1  - Accession Number: 91711375; Butrum, Ritva R. 1; Clifford, Carolyn K. 1; Lanza, Elaine 1; Affiliations: 1: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD; Issue Info: Sep1988, Vol. 48 Issue 3, p888; Thesaurus Term: Nutrition; Subject Term: Diet; Subject Term: Cancer -- Risk factors; Subject Term: Guidelines; Author-Supplied Keyword: cancer; Author-Supplied Keyword: nutrition ; Company/Entity: National Cancer Institute (U.S.) ; Company/Entity: National Academy of Sciences (U.S.) ; Company/Entity: American Cancer Society Inc. ; Company/Entity: American Heart Association; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Block, Galdys
AU  - Bosenberger, William F.
AU  - Patterson, Blossom H.
T1  - Calories, Fat and Cholesterol: Intake Patterns in the US Population by Race, Sex and Age.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/09//
VL  - 78
IS  - 9
M3  - Article
SP  - 1150
EP  - 1155
PB  - American Public Health Association
SN  - 00900036
AB  - Nutrient intakes were investigated for Blacks and Whites using data from the NHANES II survey (1976-80). Intake of energy, total fat, saturated fat, dietary cholesterol, P/S ratio, and per cent of calories derived from total and saturated fat are examined by sex and age, both in absolute terms and per unit of body weight. For most age and sex categories, Blacks are found to have a lower intake of energy and fats than Whites; however, Blacks have a consistently higher intake of dietary cholesterol. The ratio of polyunsaturated fats to saturated fats is higher in females than in males, but all age-sex groups are substantially below recommended levels. Per cent of calories from total and saturated fat are similar in most age-sex groups. Possible explanations of the observed patterns include activity level and metabolic differences. (Am J Public Health 1988; 78:1150-1155.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUTRITION research
KW  - DEMOGRAPHIC surveys
KW  - PUBLIC health
KW  - BLACKS
KW  - WHITES
KW  - SATURATED fatty acids
KW  - CHOLESTEROL
KW  - FOOD -- Caloric content
KW  - UNITED States
N1  - Accession Number: 4685842; Block, Galdys 1 Bosenberger, William F. 2 Patterson, Blossom H. 3; Affiliation:  1: Surveillance and Operations Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza No., Rm. 313, Bethesda, MD 20892  2: NCI Division, Rockville, Maryland  3: Information Management Services, Inc., Rockville, Maryland; Source Info: Sep88, Vol. 78 Issue 9, p1150; Subject Term: NUTRITION research; Subject Term: DEMOGRAPHIC surveys; Subject Term: PUBLIC health; Subject Term: BLACKS; Subject Term: WHITES; Subject Term: SATURATED fatty acids; Subject Term: CHOLESTEROL; Subject Term: FOOD -- Caloric content; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brock, Mary Anne
T1  - Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1988/09//Sep/Oct88
VL  - 76
IS  - 5
M3  - Book Review
SP  - 521
EP  - 521
SN  - 00030996
AB  - Reviews the book "Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes," by Eberhard Gwinner.
KW  - Biological rhythms
KW  - Nonfiction
KW  - Gwinner, Eberhard
KW  - Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes (Book)
N1  - Accession Number: 11887892; Brock, Mary Anne 1; Affiliations: 1: National Institute of Aging, National Institutes of Health; Issue Info: Sep/Oct88, Vol. 76 Issue 5, p521; Thesaurus Term: Biological rhythms; Subject Term: Nonfiction; Reviews & Products: Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes (Book); People: Gwinner, Eberhard; Number of Pages: 1/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Preud'Homme, J. L.
AU  - Ganeval, Dominique
AU  - GrÜnfeld, J. P.
AU  - striker, Liliane
AU  - Brouet, J. C.
T1  - Immunoglobulin synthesis in primary and myeloma amyloidosis.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1988/09//
VL  - 73
IS  - 3
M3  - Article
SP  - 389
EP  - 394
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Bone marrow cells from 14 patients with primary amyloidosis and two patients with myeloma amyloidosis were studied by immunofluorescence and biosynthesis experiments after incorporation of radioactive amino acids. Cells from four patients affected with non-myeloma secondary amyloidosis were also studied as controls. In primary amyloidosis, monoclonal plasma cell populations were demonstrated by immunofluorescence in virtually every case, even in patients without serum and urine monoclonal immunoglobulin and with a normal percentage of bone marrow plasma cells. Biosynthesis experiments showed the secretion of large amounts of free light chains, most often of the &lamda; type, in every primary or myeloma amyloidosis case and the presence of light chain fragments in almost all cases. Special features in certain patients were the synthesis of short γ chains (two cases), assembly block at the HL half molecule level of a monoclonal IgA (one case) and secretion of decameric abnormally large κ chains (one case). This is in contrast with nonmyelomatous secondary amyloidosis where the distribution of bone marrow plasma cells was normal by immunofluorescence and where normal sized immunoglobulins were synthesized, without free light chain secretion and fragments. These data confirm that primary amyloidosis belongs to plasma cell dyscrasias and emphasize the role of free light chains and light chain fragments in the pathogenesis of amyloid deposition 500 IgM nephropathy (IgMN) causes nephrotic syndrome and is characterized by IgM mesangial deposits. It is speculated that these deposits are derived from circulating IgM aggregates or immune complexes, either of which would have a molecular weight heavier than that of normal IgM. To test this hypothesis the sera of 11 patients with IgMN, five patients with nephrotic syndrome of other etiologies, and 13 normal controls were analysed for such heavy IgM. The serum samples were passed over a Biogel A5M molecular sieve column and the fractions were tested for IgM concentration by enzyme linked immunosorbent assay (ELISA). The column effluent from the void volume to the IgM peak was divided into four equal regions, and the average IgM concentrations in each region were compared. The IgMN group had significantly higher IgM concentrations than normal controls in the heaviest region (0.81 ± 0.84 vs. 0.32 ± 0.17 μg/ml; P = 0.01) and in the lightest region (95.8 ± 59.5 vs. 46.3 &plus; 41.2 μg/ml; P = 0.02). Although the IgMN group appeared to have about double the IgM levels of the nephrotic control group in all four regions, this was only significant in the lightest (19S) region. In serum samples from two IgMN patient methods known to break antigen antibody bonds eliminated the heavy IgM; in one case we used gel filtration in potassium thiocyanate and in another ultracentrifugation at pH 2.8. In addition, the heavy IgM in this second patient exhibited complement fixation activity in a sandwich ELISA for IgM-C3 complexes. We conclude that IgMN patients have circulating heavy IgM, which by preliminary studies probably consists of complement fixing IgM immune complexes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMYLOIDOSIS
KW  - BONE marrow
KW  - LYMPHOPROLIFERATIVE disorders
KW  - IMMUNOFLUORESCENCE
KW  - SERUM
KW  - URINE
KW  - immunofluorescence
KW  - immunoglobulin synthesis
KW  - myeloma
KW  - primary amyloidosis
N1  - Accession Number: 16216496; Preud'Homme, J. L. 1 Ganeval, Dominique 2 GrÜnfeld, J. P. 2 striker, Liliane 3 Brouet, J. C. 4; Affiliation:  1: Laboratory of Immunology and Immunopathology, Poitiers University Hospital, Paris.  2: Department of Nephrology, Necker Hospital, Paris.  3: National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.  4: Laboratory of Immunochemistry and Immunopathology, Saint-Louis Hospital, Paris, France.; Source Info: Aug1988, Vol. 73 Issue 3, p389; Subject Term: AMYLOIDOSIS; Subject Term: BONE marrow; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: IMMUNOFLUORESCENCE; Subject Term: SERUM; Subject Term: URINE; Author-Supplied Keyword: immunofluorescence; Author-Supplied Keyword: immunoglobulin synthesis; Author-Supplied Keyword: myeloma; Author-Supplied Keyword: primary amyloidosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Barnett, Susan C.
AU  - Evans, C. H.
T1  - Leukoregulin-induced translocation of protein kinase C activity in K562 cells.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1988/09//
VL  - 73
IS  - 3
M3  - Article
SP  - 505
EP  - 509
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Leukoregulin's effect on biochemical pathways involving Ca2+ was assessed in K562 erythroleukemia cells in which the antitumour lymphokine Induces a rapidly reversible increase in plasma membrane permeability. Leukoregulin exposure activates protein kinase C but does not alter levels of phosphoinositol metabolites, calmodulin or cAMP. The activation pattern of protein kinase C differs from that induced by phorbol myristic acid (PMA), a potent activator of protein kinase C. PMAinduced translocation of protein kinase C from the cytosol to the plasma membrane is maximal by 2 min after addition of PMA whereas after leukoregulin treatment protein kinase C translocation reaches a maximum at 2 h. This suggests that leukoregulin activates protein kinase C via a nonclassical phosphoinositol pathway as opposed to direct binding to protein kinase C as occurs with PMA. The temporal kinetics of the protein kinase C translocation and the increase in membrane permeability induced by leukoregulin are similar suggesting that phosphorylation of a membrane protein may be involved in the target cell destabilization of the plasma membrane by this lymphokine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUKEMIA
KW  - LYMPHOKINES
KW  - PROTEIN kinase C
KW  - LYMPHOCYTES
KW  - CANCER
KW  - CELL membranes
KW  - leukoregulin
KW  - lymphokine
KW  - phosophoinositides
KW  - protein kinase C
N1  - Accession Number: 16216845; Barnett, Susan C. 1 Evans, C. H. 1; Affiliation:  1: Tumor Biology Section, Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute. Bethesda, Maryland, 20892, USA.; Source Info: Aug1988, Vol. 73 Issue 3, p505; Subject Term: LEUKEMIA; Subject Term: LYMPHOKINES; Subject Term: PROTEIN kinase C; Subject Term: LYMPHOCYTES; Subject Term: CANCER; Subject Term: CELL membranes; Author-Supplied Keyword: leukoregulin; Author-Supplied Keyword: lymphokine; Author-Supplied Keyword: phosophoinositides; Author-Supplied Keyword: protein kinase C; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Platt, Mark W.
AU  - Rottem, Shlomo
AU  - Milner, Yoram
AU  - Barile, Michael F.
AU  - Peterkofsky, Alan
AU  - Reizer, Jonathan
T1  - Protein phosphorylation in Mycoplasma gallisepticum.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1988/09//9/1/88
VL  - 176
IS  - 1
M3  - Article
SP  - 62
EP  - 67
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Incubation of the soluble fraction derived from Mycoplasma gallisepticum cells with [γ-32P]ATP results in the phosphorylation of several endogenous proteins. One protein with an apparent molecular mass of 55 kDa was the acceptor of more than 95% of the radioactive phosphate. This protein was also found to be radiolabeled in intact cells grown in the presence of [32P]orthophosphate. Acid hydrolysis of the phosphorylated 55-kDa protein followed by two-dimensional electrophoresis revealed that the 32P-labeled material co-migrated with phosphoserine. The in vitro phosphorylation of the 55-kDa protein has an optimum pH of 5.5-6.0 and is not affected by various metabolites of glycolysis, by cAMP or by calmodulin with or without Ca2+. The phosphorylation is dependent upon divalent cations, a dependency that is best fulfilled by the simultaneous addition of Ca2+ and Zn2+ that act in a specific and cooperative manner. Of a variety of possible exogenous protein acceptors tested, the endogenous protein kinase was capable to phosphorylate only phosvitin. The phosphorylation of the 55-kDa protein is reversible through the activity of a phosphoprotein phosphatase present in the soluble fraction of M. gallisepticum. The phosphoprotein phosphatase has an optimum pH of 7.5 -8.0, is inhibited by NaF and stimulated to a large extent by inorganic phosphate and arsenate and to a lesser extent by pyrophosphate ATP and ADP. The possible association of the reversible protein phosphorylation to cell shape and gliding motility of M. gallisepticum are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN kinases
KW  - PHOSPHORYLATION
KW  - HYDROGEN-ion concentration
KW  - CELL morphology
KW  - PHASE partition
KW  - ELECTROPHORESIS
KW  - CHEMICAL reactions
N1  - Accession Number: 15818680; Platt, Mark W. 1 Rottem, Shlomo 1 Milner, Yoram 2 Barile, Michael F. 3 Peterkofsky, Alan 4 Reizer, Jonathan 4; Affiliation:  1: Department of Membrane and Ultrastructure Research, The Hebrew University-Hadassah Medical School, Jerusalem.  2: Department of Biological Chemistry, The Hebrew University, Jerusalem.  3: Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland.  4: National Heart, Lung, and Blood Institute, Bethesda, Maryland; Source Info: 9/1/88, Vol. 176 Issue 1, p62; Subject Term: PROTEIN kinases; Subject Term: PHOSPHORYLATION; Subject Term: HYDROGEN-ion concentration; Subject Term: CELL morphology; Subject Term: PHASE partition; Subject Term: ELECTROPHORESIS; Subject Term: CHEMICAL reactions; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Nutt, David
AU  - Ravitz, Bernard
AU  - Risher-Flowers, Debra
T1  - Binge Use of Benzodiazepines.
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1988/09//
VL  - 3
IS  - 3
M3  - Letter
SP  - 227
EP  - 227
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - Presents a letter to the editor discussing binge use of benzodiazepines, published in September 1, 1988 issue of the journal "Human Psychopharmacology."
KW  - LETTERS to the editor
KW  - BENZODIAZEPINES
N1  - Accession Number: 12371616; Nutt, David 1 Ravitz, Bernard 1 Risher-Flowers, Debra 1; Affiliation:  1: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism DICBR, 9000 Rockville Pike, Bethesda. MD 20892, USA.; Source Info: Sep88, Vol. 3 Issue 3, p227; Subject Term: LETTERS to the editor; Subject Term: BENZODIAZEPINES; Number of Pages: 1p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Psychological Resilience Among Widowed Men and Women: A 10-Year Follow-up of a National Sample.
JO  - Journal of Social Issues
JF  - Journal of Social Issues
Y1  - 1988///Fall1988
VL  - 44
IS  - 3
M3  - Article
SP  - 129
EP  - 142
SN  - 00224537
AB  - Uses data from the National Health and Nutrition Examination Survey Epidemiologic Followup Study to examine some long-term consequences of widowhood. Beginning with a sample of over 14,000 respondents between the ages of 25 to 74, a 10-year follow-up traced 94% of those initially married and 93% of the widowed. There were no differences between these groups in mortality rate when adjusted for age and education differences. The authors then compare three groups - those married at both times, those widowed during the follow-up interval, and those widowed at both times - on measures of psychosocial status and functioning at the time of the follow-up. They also analyze subsamples with data on the same variables at initial survey and follow-up. The widowed had lower family income and were more likely to have been institutionalized. However, they showed little or no difference on measures of self-rated health, activities of daily living, social network size, extraversion, openness to experience, psychological well-being, and depression. These results highlight the psychological resilience of most individuals and their capacity to adapt to stressful events and conditions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Social Issues is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MORTALITY
KW  - SOCIAL indicators
KW  - SOCIAL networks
KW  - LIFE change events
KW  - SURVEYS
KW  - WIDOWHOOD
KW  - PSYCHOLOGY
KW  - UNITED States
N1  - Accession Number: 16464784; McCrae, Robert R. 1; Costa Jr., Paul T. 1; Affiliations: 1 : National Institute on Aging.;  Source Info: Fall1988, Vol. 44 Issue 3, p129; Historical Period: 1971 to 1975; Subject Term: MORTALITY; Subject Term: SOCIAL indicators; Subject Term: SOCIAL networks; Subject Term: LIFE change events; Subject Term: SURVEYS; Subject Term: WIDOWHOOD; Subject Term: PSYCHOLOGY; Subject: UNITED States; Number of Pages: 14p; Document Type: Article
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DB  - ahl
ER  - 

TY  - JOUR
AU  - Dinse, Gregg E.
T1  - Simple Parametric Analysis of Animal Tumorigenicity Data.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1988/09//
VL  - 83
IS  - 403
M3  - Article
SP  - 638
SN  - 01621459
AB  - The usual onset/death model for tumorigenicity data can be characterized by the tumor incidence rate and the conditional death rates for tumor-free and tumor-bearing animals. If the tumor is unobservable in live animals, however, these rates are difficult to estimate without cause-of-death data or numerous sacrifices. This article proposes simple but flexible parametric models for another set of functions that can be estimated directly from survival/sacrifice data. These estimates can be transformed to obtain estimates of and suggest parametric models for other functions of interest, such as the tumor incidence rate, the conditional death rates, and the relative risk. No cause-of-death data are needed and, due to its parametric nature, the analysis requires few sacrifice times. This approach makes no assumptions about the degree of tumor lethality, nor is the tumor assumed to operate independently of other diseases. The huge ED[sub 01] study provides an excellent basis for assessing the proposed parametric approach. This unique experiment involved approximately 24,000 mice and incorporated 8 interim sacrifices at times ranging from 9 to 24 months. A known carcinogen, 2-acetylaminofluorene, was administered at various doses. The chemical affected survival only at the highest dose and had no effect on four of the six tumors investigated: uterine polyps, lung tumors, reticulum cell sarcomas, and lymphomas. A large subset of the ED[sub 01] data was formed by pooling the mice from all but the highest-dose group. This collection of nearly 20,000 mice is used to demonstrate the appropriateness of the assumed parametric models; the parametric estimates of overall survival, tumor prevalence, and tumor incidence are consistent with the nonparametric estimates. Because the mice were... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESTIMATION theory
KW  - STATISTICS
KW  - CARCINOGENESIS
KW  - BIOLOGICAL assay
KW  - PATHOLOGY
KW  - TUMORS
KW  - MORTALITY
KW  - LYMPHOMAS
KW  - Carcinogenesis bioassay
KW  - ED01 study
KW  - Incidence
KW  - Lethality
KW  - Prevalence
KW  - Survival/sacrifice experiment.
N1  - Accession Number: 4612938; Dinse, Gregg E. 1; Affiliations: 1: Mathematical Statistician, Division of Biometry and Risk Assessment, B3-02, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709.; Issue Info: Sep88, Vol. 83 Issue 403, p638; Thesaurus Term: ESTIMATION theory; Thesaurus Term: STATISTICS; Subject Term: CARCINOGENESIS; Subject Term: BIOLOGICAL assay; Subject Term: PATHOLOGY; Subject Term: TUMORS; Subject Term: MORTALITY; Subject Term: LYMPHOMAS; Author-Supplied Keyword: Carcinogenesis bioassay; Author-Supplied Keyword: ED01 study; Author-Supplied Keyword: Incidence; Author-Supplied Keyword: Lethality; Author-Supplied Keyword: Prevalence; Author-Supplied Keyword: Survival/sacrifice experiment.; Number of Pages: 12p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - WOLFFE, ALAN P.
AU  - BROWN, DONALD D.
T1  - Developmental Regulation of Two 5S Ribosomal RNA Genes.
JO  - Science
JF  - Science
Y1  - 1988/09/23/
VL  - 241
IS  - 4873
M3  - Article
SP  - 1626
EP  - 1632
SN  - 00368075
AB  - The developmental regulation oftwo kinds ofXenopus 5S RNA genes (oocyte and somatic types) can be explained by differences in the stability of protein-protein and protein-DNA interactions in a transcription complex that directs transcription initiation by RNA polymerase III. Dissociation oftranscription factors from oocyte 5S RNA genes during development allows them to be repressed by chromatin assembly. In the same cells, somatic 5S RNA genes remain active because their transcription complexes are stable. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 87461422; WOLFFE, ALAN P. 1,2 BROWN, DONALD D. 1; Affiliation:  1: Department of Embryology at the Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210  2: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 9/23/1988, Vol. 241 Issue 4873, p1626; Number of Pages: 7p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Micozzi, Marc S.
AU  - Brown, Ellen D.
AU  - Taylor, Philip R.
AU  - Wolfe, Elaine
T1  - Carotenodermia in men with elevated carotenoid intake from foods and β-carotene supplements.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/10//
VL  - 48
IS  - 4
M3  - Article
SP  - 1061
EP  - 1064
SN  - 00029165
AB  - We evaluated the relation between plasma levels of carotenoids and carotenodermia in 30 men receiving carotenoid supplementation for 42 d. Five subjects each were randomly assigned to one of six treatment groups: 30 mg purified β-carotene supplement, 12 mg β-carotene supplement, 272 g cooked carrots, 300 g cooked broccoli, 180 g tomato juice, and placebo. Definite carotenodermia was observed only in the five subjects who took 30 mg of purified β-carotene daily. Carotenodermia was first noted between 25 and 42 d after supplementation and persisted from 14 to > 42 d posttreatment and was observed only after plasma total carotenoid levels exceeded 4.0 mg/L. These observations may be useful to investigators planning clinical trials with β-carotene and to clinicians assessing the significance of carotenodermia in men taking fl-carotene supplements or following diets high in carotenoid-containing foods. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Dietary supplements
KW  - Carotenoids
KW  - Carotenes
KW  - Broccoli
KW  - Tomato juice
KW  - Clinical trials
KW  - β-carotene
KW  - Carotenodermia
KW  - carotenoids
KW  - foods
KW  - supplements
N1  - Accession Number: 91711391; Micozzi, Marc S. 1; Brown, Ellen D. 2; Taylor, Philip R. 3; Wolfe, Elaine 4; Affiliations: 1: Medical Museum, Armed Forces Institute of Pathology, Washington, DC; 2: Vitamin and Mineral Nutrition Laboratory, US Department of Agriculture, Beltsville, MD; 3: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; 4: Information Management Services, Inc, Silver Spring, MD; Issue Info: Oct1988, Vol. 48 Issue 4, p1061; Thesaurus Term: Dietary supplements; Subject Term: Carotenoids; Subject Term: Carotenes; Subject Term: Broccoli; Subject Term: Tomato juice; Subject Term: Clinical trials; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: Carotenodermia; Author-Supplied Keyword: carotenoids; Author-Supplied Keyword: foods; Author-Supplied Keyword: supplements; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Pescovitz, M. D.
AU  - Lowman, M. A.
AU  - Sachs, D. H.
T1  - Expression of T-cell associated antigens by porcine natural killer cells.
JO  - Immunology
JF  - Immunology
Y1  - 1988/10//
VL  - 65
IS  - 2
M3  - Article
SP  - 267
EP  - 271
PB  - Wiley-Blackwell
SN  - 00192805
AB  - We have examined the cell surface phenotype of porcine natural killer (NK) cells and compared them with classic porcine cytotoxic T lymphocytes (CTL). NK cells were susceptible to treatment with monoclonal antibodies to CD2 (PTI 1), CD8 (PT8) and Ia plus complement (C), as well as with antiserum to asialo-GM 1 (ASGM 1) plus C. In addition, monoclonal antibodies to leucocyte function antigen I (LFA-1) but not to CD8 blocked NK-mediated lysis in the absence of C. This is in contrast to porcine CTL, which were eliminated by antibodies to CD2, CD8 and Ia plus C, but not by antis ASGMI plus C, and which were blocked by anti-CD8 in the absence of C. Therefore, although porcine NK cells arc similar to porcine CTL, they are distinguished by several important differences. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - KILLER cells
KW  - ANTIGENS
KW  - T cells
KW  - GENE expression
KW  - GENETICS
N1  - Accession Number: 14004312; Pescovitz, M. D. 1 Lowman, M. A. 2 Sachs, D. H. 2; Affiliation:  1: Dept. of Surgery, Indiana University, UHC43O, Indianapolis, IN 76223, U.S.A.  2: Transplantation Biology Section, Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct88, Vol. 65 Issue 2, p267; Subject Term: IMMUNOGLOBULINS; Subject Term: KILLER cells; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: GENE expression; Subject Term: GENETICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Behrman, Jere R.
AU  - Deolalikar, Anil B.
AU  - Wolfe, Barbara L.
T1  - Nutrients: Impacts and Determinants.
JO  - World Bank Economic Review
JF  - World Bank Economic Review
Y1  - 1988/10//
VL  - 2
IS  - 3
M3  - Article
SP  - 299
EP  - 320
N1  - Accession Number: 55992680; Behrman, Jere R. 1; Deolalikar, Anil B. 1; Wolfe, Barbara L. 1; Affiliations: 1: Jere R. Behrman is a professor of economics at the University of Pennsylvania. Anil B. Deolalikar is a visiting associate professor of economics at Harvard University. Barbara L. Wolfe is an associate professor of economics and preventive medicine at the University of Wisconsin-Madison. They thank the Population Council Research Program on Fertility Determinants, funded by the U.S. Agency for International Development, the U.S. National Science Foundation, and the U.S. National Institutes of Health for research support for the underlying studies.; Issue Info: Oct1988, Vol. 2 Issue 3, p299; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
AU  - Edelman, Robert
T1  - Food Allergy.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/11//
VL  - 48
IS  - 5
M3  - Book Review
SP  - 1346
EP  - 1346
SN  - 00029165
KW  - Food allergy
KW  - Nonfiction
KW  - Chandra, R. K.
KW  - Food Allergy (Book)
N1  - Accession Number: 91712365; Edelman, Robert 1; Affiliations: 1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Issue Info: Nov1988, Vol. 48 Issue 5, p1346; Thesaurus Term: Food allergy; Subject Term: Nonfiction; Reviews & Products: Food Allergy (Book); People: Chandra, R. K.; Number of Pages: 1p; Document Type: Book Review
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ER  - 

TY  - JOUR
AU  - Siscovick, David S.
AU  - Lars G. Ekelund
AU  - Hyde, John S.
AU  - Johnson, Jeffrey L.
AU  - Gordon, David J.
AU  - LaRosa, Joun C.
T1  - Physical Activity and Coronary Heart Disease among Asymptomatic Hypercholesteroleimc Men.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/11//
VL  - 78
IS  - 11
M3  - Article
SP  - 1428
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We examined the relation between reported regular strenuous exercise or hard physical labor and the incidence of coronary heart disease (CHD) death and nonfatal myocardial infarction among 1,533 hypercholesterolemic men aged 35-59 years who were in the placebo group of the Lipid Research Clinics Coronary Primary Prevention Trial. The mean follow-up of the cohort was 7.4 years. The men were free of clinical heart disease at entry; men with an abnormal resting electrocardiogram or graded exercise test also were excluded.  Regular physical activity was not associated with the incidence of CHD (RR = .94, 95% CI = .68, 1.38) in this study population. Adjustment by the proportional hazards model for age, low-density lipoprotein cholesterol, smoking, family history of CHD, and occupation did not alter this finding. This observation suggests that reported regular physical activity may not be related to the risk of coronary heart disease among asymptomatic, hypercholesterolemic, middle-aged men. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXERCISE
KW  - HEALTH behavior
KW  - CORONARY heart disease
KW  - MYOCARDIAL infarction
KW  - HYPERCHOLESTEREMIA
KW  - BLOOD cholesterol
KW  - ELECTROCARDIOGRAPHY
KW  - HEART diseases -- Diagnosis
KW  - PHYSICAL fitness
N1  - Accession Number: 4688595; Siscovick, David S. 1 Lars G. Ekelund 1 Hyde, John S. 2 Johnson, Jeffrey L. 1 Gordon, David J. 3 LaRosa, Joun C. 4,5; Affiliation:  1: Collaborative Studies Coordinating Center, Departments of Epidemiology and Biostatistics, University of North Carolina  2: Department of Pathology George Washington University  3: Lipid Research Clinic. Department of Medicine, GWU  4: National Heart, Lung and Blood Institute, Lipid Metabolism-Atherogenesis Branch  5: Departments of Epidemiology and Medicine at the University of Washington, Seattle; Source Info: Nov88, Vol. 78 Issue 11, p1428; Subject Term: EXERCISE; Subject Term: HEALTH behavior; Subject Term: CORONARY heart disease; Subject Term: MYOCARDIAL infarction; Subject Term: HYPERCHOLESTEREMIA; Subject Term: BLOOD cholesterol; Subject Term: ELECTROCARDIOGRAPHY; Subject Term: HEART diseases -- Diagnosis; Subject Term: PHYSICAL fitness; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Collman, Gwen W.
AU  - Shore, Daved L.
AU  - Shy, Carl M.
AU  - Checkoway, Harvey
AU  - Luria, Alan S.
T1  - Sunlight and Other Risk Factors for Cataracts: An Epidemiologic study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1988/11//
VL  - 78
IS  - 11
M3  - Article
SP  - 1459
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: A case control study was conducted in North Carolina to explore the relation between individual exposure to sunlight and the risk of cataracts. One hundred thirteen cases and 161 controls aged 40-69 at diagnosis were studied. Sunlight exposure was inferred from interview data on residency and time spent in the sun, combined with solar radiation data from the National Climatic Data Center. Sunlight exposure was very slightly related to all types of opacities combined. Although the numbers of cases with each type of opacity was small, the risk of cataracts was slightly increased in medium and high exposure categories for persons having cortical or posterior subcapsular opacities only, but not nuclear sclerotic changes. Persons with dark brown or hazel eyes are at increased risk. An unexpected finding was that persons who reported using tranquilizers for six months were at increased risk. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CATARACT
KW  - CRYSTALLINE lens -- Diseases
KW  - SOLAR radiation
KW  - OPACITY (Optics)
KW  - LIGHT absorption
KW  - EPIDEMIOLOGY
KW  - DISEASES -- Causes & theories of causation
KW  - PUBLIC health research
KW  - VISION
KW  - OLD age
N1  - Accession Number: 4690791; Collman, Gwen W. 1 Shore, Daved L. 2 Shy, Carl M. 3 Checkoway, Harvey 4 Luria, Alan S. 5; Affiliation:  1: Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park. NC 22709  2: Branch at NIEHS  3: Department of Epidemiology, UNC School of Public Health  4: Department of Environmental Health, School of Public Health, University of Washington, Seattle  5: Asheboro Ophthalmology Associates, Inc., Asheboro, NC; Source Info: Nov88, Vol. 78 Issue 11, p1459; Subject Term: CATARACT; Subject Term: CRYSTALLINE lens -- Diseases; Subject Term: SOLAR radiation; Subject Term: OPACITY (Optics); Subject Term: LIGHT absorption; Subject Term: EPIDEMIOLOGY; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: PUBLIC health research; Subject Term: VISION; Subject Term: OLD age; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Martin, George R.
T1  - Developmental Biology, A Comprehensive Synthesis, Vol. 3: The Cell Surface in Development and Cancer (Book).
JO  - American Scientist
JF  - American Scientist
Y1  - 1988/11//Nov/Dec88
VL  - 76
IS  - 6
M3  - Book Review
SP  - 618
EP  - 618
SN  - 00030996
AB  - Reviews the book "Developmental Biology, A Comprehensive Synthesis, Vol. 3: The Cell Surface in Development and Cancer," edited by Malcolm  Steinberg.
KW  - Developmental biology
KW  - Nonfiction
KW  - Steinberg, Malcolm
KW  - Developmental Biology: A Comprehensive Synthesis: The Cell Surface in Development & Cancer (Book)
N1  - Accession Number: 11757118; Martin, George R. 1; Affiliations: 1: National Institutes of Health, Bethesda; Issue Info: Nov/Dec88, Vol. 76 Issue 6, p618; Thesaurus Term: Developmental biology; Subject Term: Nonfiction; Reviews & Products: Developmental Biology: A Comprehensive Synthesis: The Cell Surface in Development & Cancer (Book); People: Steinberg, Malcolm; Number of Pages: 1/4p; Document Type: Book Review
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ER  - 

TY  - JOUR
AU  - Yanagishita, Machiko
AU  - Guralnik, Jack M.
T1  - Changing Mortality Patterns That Led Life Expectancy in Japan to Surpass Sweden's: 1972-1982.
JO  - Demography
JF  - Demography
Y1  - 1988/11//
VL  - 25
IS  - 4
M3  - Article
SP  - 611
EP  - 624
SN  - 00703370
AB  - Between 1972 and 1982, Japan caught up to and then surpassed Sweden as the country with the longest life expectancy. The contributions of different causes of death and age groups to life expectancy changes in males during this time period are examined in detail for these two countries. Even though cerebrovascular disease mortality rates remained lower in Sweden over the entire interval, the rapid gain made by Japan relative to Sweden for this cause of death was a prime factor in Japan's ending the period with a higher life expectancy. Important contributions to life expectancy improvement in Japan came from declining mortality rates in those aged 55 and older. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MORTALITY
KW  - LONGEVITY
KW  - QUALITY of life
KW  - OLD age
KW  - SOCIAL indicators
KW  - AGE groups
N1  - Accession Number: 16799696; Yanagishita, Machiko 1; Guralnik, Jack M. 1; Affiliations: 1: Epidemiology, Biometry, and Demography Program, National Institute on Aging, 7550 Wisconsin Avenue, Bethesda, Maryland 20892; Issue Info: Nov1988, Vol. 25 Issue 4, p611; Subject Term: MORTALITY; Subject Term: LONGEVITY; Subject Term: QUALITY of life; Subject Term: OLD age; Subject Term: SOCIAL indicators; Subject Term: AGE groups; Number of Pages: 14p; Document Type: Article
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DB  - buh
ER  - 

TY  - JOUR
AU  - Smith, C. A. D.
AU  - Louis, M. J.
AU  - Hetrick, F. M.
T1  - A sequence homologous to the mammalian p53 oncogene in fish cell lines.
JO  - Journal of Fish Diseases
JF  - Journal of Fish Diseases
Y1  - 1988/11//
VL  - 11
IS  - 6
M3  - Article
SP  - 525
EP  - 530
PB  - Wiley-Blackwell
SN  - 01407775
AB  - This article presents a study of a sequence homologous to the mammalian p53 oncogene in fish cell lines. The p53 protein is species-specific and appears conserved through evolution in mammals. The widespread occurrence of neoplasia in fish and the need to describe the evolutionary development and diversity of proto-oncogene sequences, make the study of genes homologous to those of the mammalian proto-oncogenes important in understanding tumour formation in lower vertebrates and higher animals. The results give preliminary, yet clear, evidence for the presence of a p53-like sequence in the EPC and CHSE-214 cell lines thus extending the knowledge of the evolutionary range of the p53 gene to fish.
KW  - FISHES
KW  - CELL culture
KW  - CELL lines
KW  - TUMORS
KW  - MAMMALS
KW  - ANTIONCOGENES
N1  - Accession Number: 15408729; Smith, C. A. D. 1 Louis, M. J. 1 Hetrick, F. M. 2; Affiliation:  1: Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA.  2: Department of Microbiology, University of Maryland, USA.; Source Info: Nov1988, Vol. 11 Issue 6, p525; Subject Term: FISHES; Subject Term: CELL culture; Subject Term: CELL lines; Subject Term: TUMORS; Subject Term: MAMMALS; Subject Term: ANTIONCOGENES; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - van der Ley, P.
T1  - Three copies of a single protein ll-encoding sequence in the genome of Neisseria gonorrhoeae JS3: evidence for gene conversion and gene duplication.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1988/11//
VL  - 2
IS  - 6
M3  - Article
SP  - 797
EP  - 806
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Gonococci express a family of related outer membrane proteins designated protein II (P.II). These surface proteins are subject to both phase variation and antigenic variation. The P.II gene repertoire of Neisseria gonorrhoeae strain JS3 was found to consist of at least ten genes, eight of which were cloned. Sequence analysis and DNA hybridization studies revealed that one particular P.II-encoding sequence is present in three distinct, but almost identical, copies in the JS3 genome. These genes encode the P.II protein that was previously identified as P.IIc. Comparison of their sequences shows that the multiple copies of this P.IIc-encoding gene might have been generated by both gene conversion and gene duplication. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Hybridization
KW  - Neisseria gonorrhoeae
KW  - Membrane proteins
KW  - Genes
KW  - Antigenic determinants
KW  - Microbial genomes
KW  - Microbial genetics
N1  - Accession Number: 18278442; van der Ley, P. 1,2; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA; 2: National Institute of Public Health and Environmental Hygiene, PO Box 1, 3720 BA Bilthoven, The Netherlands; Issue Info: Nov1988, Vol. 2 Issue 6, p797; Thesaurus Term: Hybridization; Subject Term: Neisseria gonorrhoeae; Subject Term: Membrane proteins; Subject Term: Genes; Subject Term: Antigenic determinants; Subject Term: Microbial genomes; Subject Term: Microbial genetics; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Looker, Anne C.
AU  - Johnson, Clifford L.
AU  - Underwood, Barbara A.
T1  - Serum retinol levels of persons aged 4-74 years from three Hispanic groups.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1988/12//
VL  - 48
IS  - 6
M3  - Article
SP  - 1490
EP  - 1496
SN  - 00029165
AB  - Previous research suggests that Hispanics in this country may have poor vitamin A status. Using serum retinol data from the Hispanic Health and Nutrition Examination Survey, we examined the vitamin A status of Mexican Americans (MA), Cubans, and Puerto Ricans (PR) aged 4-74 y. MA had lower mean serum retinol levels and higher prevalences of serum retinol in the range 0.70-1.01 µmol/L than did Cubans in several age-sex groups. The prevalence (or percentage) of serum retinol in a range indicating possible risk of functional impairment was not elevated in any of the Hispanic groups except the females aged 18-44 y. However, a high percentage of children and adolescents in the three Hispanic groups had serum retinol values in ranges that might indicate less-than-optimal vitamin A status. Determination of vitamin A status requires a more definitive assessment than by serum vitamin A alone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Vitamin A
KW  - Mexican Americans
KW  - Cubans
KW  - Hispanic Americans
KW  - Age groups
KW  - Children
KW  - Ethnic groups
KW  - nutrition surveys
KW  - vitamin A
N1  - Accession Number: 91711440; Looker, Anne C. 1; Johnson, Clifford L. 1; Underwood, Barbara A. 1; Affiliations: 1: Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville and the National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Dec1988, Vol. 48 Issue 6, p1490; Subject Term: Vitamin A; Subject Term: Mexican Americans; Subject Term: Cubans; Subject Term: Hispanic Americans; Subject Term: Age groups; Subject Term: Children; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: nutrition surveys; Author-Supplied Keyword: vitamin A; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lambert, Paul F.
AU  - Baker, Carl C.
AU  - Howley, Peter M.
T1  - THE GENETICS OF BOVINE PAPILLOMAVIRUS TYPE 1.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1988/12//
VL  - 22
M3  - Article
SP  - 235
EP  - 258
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Investigates the genetics of bovine papillomavirus type 1 (BPV-1). Nature of papillomaviruses; Association of BPV-1 with cutaneous fibropapillomas in cattle; Structure of the BPV-1 genome; Transcription of the BPV-1 genome.
KW  - PAPILLOMAVIRUSES
KW  - CATTLE
KW  - VIRUSES
KW  - VIRAL genetics
KW  - MICROBIAL genetics
KW  - BIOCHEMICAL genetics
KW  - MOLECULAR genetics
KW  - MOLECULAR biology
N1  - Accession Number: 17740512; Lambert, Paul F. 1 Baker, Carl C. 1 Howley, Peter M. 1; Affiliation:  1: Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892; Source Info: 1988, Vol. 22, p235; Subject Term: PAPILLOMAVIRUSES; Subject Term: CATTLE; Subject Term: VIRUSES; Subject Term: VIRAL genetics; Subject Term: MICROBIAL genetics; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: MOLECULAR biology; Number of Pages: 24p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scriver, Charles R.
AU  - Kaufman, Seymour
AU  - Woo, Savio L. C.
T1  - MENDELIAN HYPERPHENYLALANINEMIA.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1988/12//
VL  - 22
M3  - Article
SP  - 301
EP  - 321
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Examines aspects of the Mendelian hyperphenylalaninemias in man. Recognition of phenylalanine as an essential amino acid in humans; Components of the hydroxylation reaction; Putative mechanism of the deviant gene dosage effect.
KW  - PHENYLALANINE
KW  - AMINO acids
KW  - HUMAN genetics
KW  - GENETIC research
KW  - BIOCHEMICAL genetics
KW  - MOLECULAR genetics
KW  - MOLECULAR biology
N1  - Accession Number: 17740547; Scriver, Charles R. 1 Kaufman, Seymour 2 Woo, Savio L. C. 3; Affiliation:  1: The Centre for Human Genetics, McGill University and The deBelle Laboratory, Division of Medical Genetics, McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3  2: National Institutes of Health, Laboratory for Neurochemistry, Building 36, Room 3D3O, Bethesda, Maryland 20014  3: Howard Hughes Medical Institute, Baylor College of Medicine, I Baylor Plaza, M905, Houston, Texas 77030; Source Info: 1988, Vol. 22, p301; Subject Term: PHENYLALANINE; Subject Term: AMINO acids; Subject Term: HUMAN genetics; Subject Term: GENETIC research; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: MOLECULAR biology; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 21p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - O'Brien, Stephen J.
AU  - Seuánez, Héctor N.
AU  - Womack, James E.
T1  - MAMMALIAN GENOME ORGANIZATION: AN EVOLUTIONARY VIEW.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1988/12//
VL  - 22
M3  - Article
SP  - 323
EP  - 351
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Provides an overview of the state of comparative genetics in mammals. Development of animal models of human inborn errors; Complexities of mammalian immune gene complexes; Application of hybrid somatic cells to gene mapping.
KW  - GENETIC research
KW  - ANIMAL models in research
KW  - BIOCHEMICAL genetics
KW  - MOLECULAR genetics
KW  - MOLECULAR biology
N1  - Accession Number: 17740551; O'Brien, Stephen J. 1 Seuánez, Héctor N. 1 Womack, James E. 2; Affiliation:  1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701-1013  2: Department of Veterinary Pathology, Texas A&M University, College Station, Texas 77843; Source Info: 1988, Vol. 22, p323; Subject Term: GENETIC research; Subject Term: ANIMAL models in research; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: MOLECULAR biology; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 29p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Washington, R.;
AU  - Farinas, E.;
AU  - Gallelli, J. F.;
T1  - ANALYSIS OF PATIENT MEDICATION AWARENESS IN A NEUROLOGY OUTPATIENT CLINIC
CT  - ANALYSIS OF PATIENT MEDICATION AWARENESS IN A NEUROLOGY OUTPATIENT CLINIC
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1988/12/01/
VL  - 23
IS  - Dec
SP  - P
EP  - 9
AD  - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892
N1  - Accession Number: 26-03538; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education
N2  - The medication knowledge of epileptic outpatients was assessed. Questionnaires were distributed during clinic sessions to epileptic outpatients on anticonvulsants whose written or oral communication skills were not impaired or who had a primary caregiver present. Patients were considered to be aware of their medication regimen if they correctly completed five questionnaire items\M/name of medication, color, strength, reasons for use, and directions for use\M/for each of their antiepileptic medications. In order to obtain additional information on contributing factors to patients\PR/ level of awareness, items to help determine (1) the primary source of patients\PR/ medication knowledge, (2) the adequacy of the time spent by the primary teacher on instructing patients, (3) the methods used to communicate the patients\PR/ medication information and (4) the ability of the patient to adhere to his medication regimen independently were included in the questionnaire. Twenty-four epileptic outpatients participated in this analysis. Sixteen (67%) patients were aware of their medication regimen. Eight (33%) patients were unaware of their medication regimen and unable to answer the questionnaire's five chart items with correct or complete information on their anticonvulsants. Factors contributing to patient medication awareness were analyzed and are reported. Pharmacy intervention is probably needed in this clinic since a significant percentage of these outpatients were unaware of their medication regimens. Suggested improvements in the outpatient pharmacy's service of epileptic outpatients could include: (1) more collaboration between the neurology clinic and the outpatient pharmacy in identifying patients who require additional assistance with their medication regimen, (2) the introduction of a requirement that epileptic patients state their medication regimen before their prescription is dispensed, and (3) the education of pharmacists to the special needs of these patients and the methods available to assist these patients in increasing their medication awareness.
KW  - Patient education--analysis--awareness evaluation;
KW  - Patients--outpatients--medication knowledge;
KW  - ASHP meeting abstracts--patient education evaluation;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Fleg, Jerome L.
T1  - Ventricular arrhythmias in the elderly: Prevalence, mechanisms, and therapeutic implications.
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1988/12//
VL  - 43
IS  - 12
M3  - Article
SP  - 23
EP  - 29
SN  - 0016867X
N1  - Accession Number: 15864367; Fleg, Jerome L. 1; Source Information: Dec1988, Vol. 43 Issue 12, p23; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3296
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 108181449
T1  - Ventricular arrhythmias in the elderly: prevalence, mechanisms, and therapeutic implications.
AU  - Fleg, J L
Y1  - 1988/12//
N1  - Accession Number: 108181449. Language: English. Entry Date: 20120504. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985102R. 
KW  - Aging -- Physiology
KW  - Arrhythmia -- Physiopathology
KW  - Aged
KW  - Antiarrhythmia Agents -- Therapeutic Use
KW  - Arrhythmia -- Diagnosis
KW  - Arrhythmia -- Therapy
KW  - Electrocardiography
KW  - Exercise Test
KW  - Heart Diseases -- Physiopathology
KW  - Heart Ventricle -- Physiopathology
KW  - Middle Age
SP  - 23
EP  - 29
JO  - Geriatrics
JF  - Geriatrics
JA  - GERIATRICS
VL  - 43
IS  - 12
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
SN  - 0016-867X
AD  - Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore.
U2  - PMID: 3056779.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lessin, Stuart R.
AU  - Huebner, Kay
AU  - Isobe, Masaharu
AU  - Croce, Carlo M.
AU  - Steinert, Peter M.
T1  - Chromosomal Mapping of Human Keratin Genes: Evidence of Non-linkage.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1988/12//
VL  - 91
IS  - 6
M3  - Article
SP  - 572
EP  - 578
SN  - 0022202X
AB  - We have determined the chromosomal location of the genes for the human keratin intermediate filament proteins K1 (type II; 67 kDa) and K10 (type I; 57 kDa) by the use of specific cDNA clones in conjunction with somatic cell hybrid analysis and in situ hybridization. The K1 keratin gene maps to chromosome region 12q11 → q13; the K10 keratin gene maps to chromosome region 17q12 → q21. Each gene has been mapped relative to other genes known to be localized on chromosomes 12 and 17, respectively. In somatic cell hybrid analysis, the K1 gene segregates concordantly with the Hox-3 homeo box gene cluster at chromosome region 12p12 → q13. The K10 gene localizes to a region proximal to a breakpoint at 17q21 which is involved in a t(17;21) (q21;q22) translocation. associated with an acute leukemia. K10 appears to be distal (telomeric) to the gene loci for G-CSF, erb-A, and Her-2, which map to chromosome region 17q12 → q21. The NGFR gene and Hox-2 homeo box locus are localized distal to the 17q21 break point and thus distal to the K10 gene. These data demonstrate that keratin genes K1 and K10, which are coexpressed in terminally differentiated epidermis, are not linked in the human genome, implying the existence of transacting factors involved in the regulation of expression of these genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEREDITY
KW  - GENETICS
KW  - CELL nuclei
KW  - GENES
KW  - GENOMES
KW  - HUMAN chromosomes
N1  - Accession Number: 12477087; Lessin, Stuart R. 1 Huebner, Kay 2 Isobe, Masaharu 2 Croce, Carlo M. 2 Steinert, Peter M. 3; Affiliation:  1: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.  2: The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania.  3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec88, Vol. 91 Issue 6, p572; Subject Term: HEREDITY; Subject Term: GENETICS; Subject Term: CELL nuclei; Subject Term: GENES; Subject Term: GENOMES; Subject Term: HUMAN chromosomes; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12477087
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05468-053
AN  - 2006-05468-053
AU  - Richters, John
T1  - Perspectives on a Phenomena Lost.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/12//
VL  - 33
IS  - 12
SP  - 1091
EP  - 1091
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05468-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Richters, John; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Experimentation; Psychology. Minor Descriptor: Psychologists. Classification: General Psychology (2100). Population: Human (10). Reviewed Item: Valsiner, Jaan (Ed). The Individual Subject and Scientific Psychology=New York: Plenum Press, 1986. 408 pp. $45.00; 1986. Page Count: 1. Issue Publication Date: Dec, 1988. 
AB  - Reviews the book, The Individual Subject and Scientific Psychology by Jaan Valsiner (Ed.) (1986). Psychologists are socialized through training and practice into a very specialized subculture, narrowly defined by established values, priorities, assumptions, and ways of thinking about things. The issues dealt with in this volume should be of interest and concern to researchers in all areas of psychology. The book may be of particular interest to developmental psychologists because so many of the contributors are themselves developmentalists. But the issues transcend subspecialty boundaries and warrant the attention of anyone concerned with the adequacy-to-phenomena shortcomings of our most widely used methods of design and analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - scientific psychology
KW  - research
KW  - 1988
KW  - Experimentation
KW  - Psychology
KW  - Psychologists
KW  - 1988
U2  - Valsiner, Jaan (Ed). (1986); The Individual Subject and Scientific Psychology; New York: Plenum Press, 1986. 408 pp. $45.00; 0-306-42250-6.
DO  - 10.1037/026351
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05468-056
AN  - 2006-05468-056
AU  - Tabakoff, Boris
T1  - The Inebriation of the Russian Soul.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1988/12//
VL  - 33
IS  - 12
SP  - 1093
EP  - 1093
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05468-056. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tabakoff, Boris; National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Alcohol Drinking Patterns; Alcoholism; History. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Location: Russia. Reviewed Item: Segal, Boris M. Russian Drinking: Use and Abuse of Alcohol in Pre-Revolutionary Russia=New Brunswick, NJ: Rutgers Center of Alcohol Studies, 1987. 383 pp. $29.95 hardcover; $19.95 paperback; 1987. Page Count: 1. Issue Publication Date: Dec, 1988. 
AB  - Reviews the book, Russian Drinking: Use and Abuse of Alcohol in Pre-Revolutionary Russia by Boris M. Segal (1987). This book is a chronology of Russian drinking customs from the tribal beginnings of the Russian Empire in the pre-Christian era to the time of the demise of the czarist regime at the hands of the Bolsheviks. The author well describes the history of government attitudes toward the consumption of alcohol by the population, as well as the aspects of the Russian culture, such as child rearing practices, that help explain Russian drinking habits. The book, as a whole, provides a satisfying synopsis of history and culture in juxtaposition to the evolution of alcohol consumptive behaviors. The text contains a wealth of information about the history of Russian drinking establishments, Russian concepts of alcoholism, early approaches to treatment and prevention, and even a discourse on prerevolutionary research on alcoholism by Russian scientists (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Russian history
KW  - alcoholism
KW  - 1988
KW  - Alcohol Drinking Patterns
KW  - Alcoholism
KW  - History
KW  - 1988
U2  - Segal, Boris M. (1987); Russian Drinking: Use and Abuse of Alcohol in Pre-Revolutionary Russia; New Brunswick, NJ: Rutgers Center of Alcohol Studies, 1987. 383 pp. $29.95 hardcover; $19.95 paperback; 0-911290-18-4 (Hardcover); 0-911290-19-2 (Paperback).
DO  - 10.1037/026354
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - Gen
ID  - 9999-25491-000
AN  - 9999-25491-000
AU  - Krupp, Lauren B.
AU  - LaRocca, Nicholas G.
AU  - Muir-Nash, Joanne
AU  - Steinberg, Alfred D.
T1  - Fatigue Severity Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1989///
AD  - Krupp, Lauren B., State University of New York at Stony Brook, School of Medicine, Department of Neurology, Health Sciences Center, Stony Brook, New York, United States, 11794-8121
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No
N1  - Accession Number: 9999-25491-000. Acronyms: FSS. Partial author list: First Author & Affiliation: Krupp, Lauren B.; State University of New York at Stony Brook, Department of Neurology, Stony Brook, New York, United States. Release Date: 20160314. Correction Date: 20160411. Instrument Type: Rating Scale. Test Location: Table 2, Page 1122. Test Format: This 9-item measure utilizes a 7-point scale where 1 indicates 'strongly disagree' and 7, 'strongly agree.'. Language: English. Constructs: Fatigue Severity; Classification: Physical Health/Illness Related Assessment (7300). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300). Other Versions: 9999-29218-000, Fatigue Severity Scale Short Form, Revision. 
AB  - Purpose: The purpose of the Fatigue Severity Scale is to assess self-reported disabling fatigue in order to facilitate research and patient treatment.
AB  - Description: The Fatigue Severity Scale (FSS; Krupp et al., 1989) is a 9-item, Likert-scaled measure of fatigue severity as reported by patients with medical and neurologic disorders. Development of the FSS began with a 28-item fatigue questionnaire, which was administered to patients with multiple sclerosis (MS), patients with systemic lupus erythematosus (SLE), and healthy adult controls. Using factor analysis, item analysis, and theoretical considerations, 9 items from the fatigue questionnaire were selected that identified features of fatigue common to the MS and SLE patient groups (e.g., 'Fatigue interferes with my physical functioning'). Results of analyses revealed that the FSS was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Disabling Fatigue
KW  - Discriminative Ability
KW  - Fatigue Severity Rating
KW  - Fatigue Severity Scale
KW  - Internal Consistency
KW  - Multiple Sclerosis
KW  - Self-Report
KW  - Systemic Lupus Erythematosus
KW  - Test Development
KW  - Test Sensitivity
KW  - Test Validity
KW  - Test-Retest Reliability
U5  - Fatigue Severity Scale (FSS) [Test Development]The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus. (AN: 2016-03727-001 from PsycINFO) Krupp, Lauren B.; LaRocca, Nicholas G.; Muir-Nash, Joanne; Steinberg, Alfred D.; Oct, 1989. Source: Archives of Neurology. 46(10), American Medical Association, US; Oct, 1989; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Outpatient; Location: United States; Samples: Patients with Multiple Sclerosis; Patients with Systemic Lupus Erythematosus; Healthy Adult Controls Keywords: Disabling Fatigue; Discriminative Ability; Fatigue Severity Rating; Fatigue Severity Scale; Internal Consistency; Multiple Sclerosis; Self-Report; Systemic Lupus Erythematosus; Test Development; Test Sensitivity; Test Validity; Test-Retest Reliability; Subjects: Fatigue; Lupus; Multiple Sclerosis; Physical Health Assessment; Rating Scales; Self-Report; Severity (Disorders); Test Construction; Test Reliability; Test Sensitivity; Test Validity;
DO  - 10.1037/t25491-000
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-35126-000
AN  - 9999-35126-000
AU  - Brott, Thomas
AU  - Adams, Harold P. Jr.
AU  - Olinger, Charles P.
AU  - Marler, John R.
AU  - Barsan, William G.
AU  - Biller, José
AU  - Spilker, Judith
AU  - Holleran, Renée
AU  - Eberle, Robert
AU  - Hertzberg, Vicki
AU  - Rorick, Marvin
AU  - Moomaw, Charles J.
AU  - Walker, Michael
T1  - National Institutes of Health Stroke Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1989///
AD  - Brott, Thomas, Department of Neurology, University of Cincinnati Medical Center, 231 Bethesda Avenue, Cincinnati, Ohio, United States, 45267-0525
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-35126-000. Other Names: NIH Stroke Scale. Acronyms: NIHSS. Partial author list: First Author & Affiliation: Brott, Thomas; University of Cincinnati, Cincinnati, Ohio, United States. Release Date: 20160411. Correction Date: 20160509. Instrument Type: Rating Scale. Test Location: Figure 1, Page 865. Test Format: The NIHSS contains 15 items rated on 3- and 4-point response scales, with varying anchor statements.. Language: English. Constructs: Cerebral Infarction; Classification: Neuropsychological Assessment (6900). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Other Versions: 9999-47097-000, National Institutes of Health Stroke Scale—Arabic Version, Translation. 
N2  - Administration Method: Other
AB  - Purpose: The NIHSS is a brief stroke examination that was developed for use in acute stroke therapy trials.
AB  - Description: The National Institutes of Health Stroke Scale (NIHSS; Brott et al., 1989) was developed for use in acute stroke therapy trials. The scale contains 15 examination items, rated on 3- and 4-point scales with varying anchor statements. Example examination items include, 'Pupillary response' (0=Both reactive, 1=One reactive, 2=Neither reactive), 'Plantar Reflex' (4-point scale, with 0=Normal, 3=Bilateral extensor), and 'Dysarthria' (3-point scale, 0=normal articulation, 2=Near unintelligible). The examination can be performed quickly, on average less than 7 minutes, by either nurses or physicians. In a study of 24 stroke patients, interrater reliability for the neurologic examination was found to be high (mean Kappa=0.69), and test-retest reliability was also high (mean Kappa=0.66-0.77). The stroke scale validity was assessed by comparing the scale scores obtained prospectively on 65 acute stroke patients to the patients' infarction size as measured by computed tomography scan at 1 week and to the patients' clinical outcome as determined at 3 months. These correlations (scale-lesion size r=0.68, scale-outcome r=0.79) suggested acceptable examination and scale validity. Of the 15 test items, the most interrater reliable item (pupillary response) had low validity. Less reliable items such as upper or lower extremity motor function were more valid. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - National Institutes of Health Stroke Scale
KW  - Test Development
KW  - Interrater Reliability
KW  - Test-Retest Reliability
KW  - Test Validity
KW  - Acute Cerebral Infarction
U5  - National Institutes of Health Stroke Scale (NIHSS) [Test Development]Measurements of acute cerebral infarction: A clinical examination scale. (AN: 2016-09459-001 from PsycINFO) Brott, Thomas; Adams, Harold P. Jr.; Olinger, Charles P.; Marle, John R.; Barsan, William G.; Biller, José; Spilker, Judith; Holleran, Renée; Eberle, Robert; Hertzberg, Vicki; Rorick, Marvin; Moomaw, Charles J.; Walker, Michael; Jan, 1989. Source: Stroke. 20(7), American Heart Association, US; Jan, 1989; Administration: Other Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Stroke Patients; Location: United States Keywords: National Institutes of Health Stroke Scale; Test Development; Interrater Reliability; Test-Retest Reliability; Test Validity; Acute Cerebral Infarction; Subjects: Cerebrovascular Accidents; Interrater Reliability; Neuropsychological Assessment; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t35126-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-35126-000&site=ehost-live&scope=site
UR  - http://rehabmeasures.org/Lists/RehabMeasures/DispForm.aspx?ID=914
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Biben, Maxeen
AU  - Symmes, David
AU  - Bernhards, Deborah
T1  - Vigilance During Play in Squirrel Monkeys.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1989/01//
VL  - 17
IS  - 1
M3  - Article
SP  - 41
EP  - 49
SN  - 02752565
AB  - Play by young squirrel monkeys (Saimiri boliviensis) may put them and other troop members at risk for predation because youngsters are noisy, separated from adults, and not vigilant when at play. In a study using separated groups of adults and 1-year-old juveniles caged outdoors, we found that adult female squirrel monkeys become more vigilant during periods of spontaneous play among juveniles. This behavioral response could be obtained with auditory cues (play vocalizations) alone. Five times as much vigilance activity was directed toward an area from which threat or disturbance was likely to come as was directed toward the juveniles themselves. These results suggest both an adaptive, compensatory increase in adult vigilance during play and a function for play vocalizations. Additional functions for play vocalizations remain to be investigated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUIRREL monkeys
KW  - BEHAVIOR
KW  - SOCIAL behavior in animals
KW  - SOUND production by animals
KW  - ANIMAL behavior
KW  - MONKEYS -- Behavior
KW  - PLAY behavior in animals
KW  - antipredator behavior
KW  - social behavior
KW  - vocal behavior
N1  - Accession Number: 12319016; Biben, Maxeen 1 Symmes, David 1 Bernhards, Deborah 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development; Source Info: 1989, Vol. 17 Issue 1, p41; Subject Term: SQUIRREL monkeys; Subject Term: BEHAVIOR; Subject Term: SOCIAL behavior in animals; Subject Term: SOUND production by animals; Subject Term: ANIMAL behavior; Subject Term: MONKEYS -- Behavior; Subject Term: PLAY behavior in animals; Author-Supplied Keyword: antipredator behavior; Author-Supplied Keyword: social behavior; Author-Supplied Keyword: vocal behavior; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Micozzi, Marc S.
AU  - Carter, Christine L.
AU  - Albanes, Demetrius
AU  - Taylor, Philip R.
AU  - Licitra, Lisa M.
T1  - Bowel Function and Breast Cancer in US Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/01//
VL  - 79
IS  - 1
M3  - Article
SP  - 73
EP  - 75
PB  - American Public Health Association
SN  - 00900036
AB  - We studied bowel function in relation to 123 breast cancer cases among 7,702 women from the US NHANES I Epidemiologic Follow-up Study. Results suggest a slight increased risk of breast cancer for both decreased frequency of bowel movements (relative risk = 1.5, 95% confidence interval = 0.8, 2.7) and firm stool consistency (RR = 1.8, 95% CI = 1.0, 3.2.) These observations are consistent with an hypothesized association between constipation and increased risk of breast cancer. (Am J Public Health 1989; 79: 73-75.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BREAST cancer -- Research
KW  - INTESTINAL diseases
KW  - PUBLIC health
KW  - INFLAMMATORY bowel diseases
KW  - WOMEN -- Health
KW  - CANCER patients
KW  - CANCER -- Study & teaching
KW  - CANCER in women
KW  - UNITED States
N1  - Accession Number: 4685487; Micozzi, Marc S. 1 Carter, Christine L. 2 Albanes, Demetrius 2 Taylor, Philip R. 2 Licitra, Lisa M. 3; Affiliation:  1: Associate Director, armed Forces Institute of Pathology, Washington, DC 20306-6000  2: Cancer Prevention studies Branch, National Cancer Institute, Bethesda, MD  3: Information Management Services Silver Spring MD; Source Info: Jan1989, Vol. 79 Issue 1, p73; Subject Term: BREAST cancer -- Research; Subject Term: INTESTINAL diseases; Subject Term: PUBLIC health; Subject Term: INFLAMMATORY bowel diseases; Subject Term: WOMEN -- Health; Subject Term: CANCER patients; Subject Term: CANCER -- Study & teaching; Subject Term: CANCER in women; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
AU  - Williams, T. Franklin
AD  - National Institutes of Health
A2  - Eisdorfer, Carl
A2  - Kessler, David A.
A2  - Spector, Abby N.
T1  - Approaches to Health
T2  - Caring for the elderly: Reshaping health policy
PB  - Johns Hopkins Series in Contemporary Medicine and Public Health
PB  - Baltimore and London:
PB  - Johns Hopkins University Press
Y1  - 1989///
SP  - 482
EP  - 489
N1  - Accession Number: 0256433; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 199203
KW  - Economics of Health (including medical subsidy programs)          9130
KW  - Economics of Aging          9180
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Lal, R. B.
AU  - Ottesen, E. A.
T1  - Antibodies to phosphocholine-bearing antigens in lymphatic filariasis and changes following treatment with diethylcarbamazine.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1989/01//
VL  - 75
IS  - 1
M3  - Article
SP  - 52
EP  - 57
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Sera from a total of 78 patients infected with Wuchereria bancrofti or appropriate controls were assayed for anti-phosphocholine antibodies in an enzyme-linked immunosorbent-assay (ELISA), using phosphocholine as an antigen, Anti-PC antibodies (both IgM and IgG) were observed in patients with all clinical forms of filariasis but, unexpectedly, were not significantly different from those of normal controls. Among the filariasis patients, however, individuals with patent microfilaraemia had significantly lower IgM-anti-PC titres (P < 0.05) than did those of the other clinical groups. Competitive studies showed that "naturally occurring' anti-PC antibodies interfere with PC antigen detection. Transient increases in the levels of ciruculating PC antigen were found by 3 days after treatment of microfilaraemic individuals with the filaricidal drug diethylcarbamazine. The subsequent decreases in antigen levels were generally associated with increased IgM- and IgG-anti- PC antibody levels. Such changes likely affect not only the ability to monitor the parasitological status of such individuals, but also the patient's subsequent immune interactions with filarial parasites. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - ENZYME-linked immunosorbent assay
KW  - ANTIGENS
KW  - FILARIASIS
KW  - PARASITES
KW  - HELMINTHIASIS
KW  - diethylcarbamazine
KW  - filariasis
KW  - phosphocholine antibodies
N1  - Accession Number: 16173974; Lal, R. B. 1 Ottesen, E. A. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA.; Source Info: Jan1989, Vol. 75 Issue 1, p52; Subject Term: IMMUNOGLOBULINS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: ANTIGENS; Subject Term: FILARIASIS; Subject Term: PARASITES; Subject Term: HELMINTHIASIS; Author-Supplied Keyword: diethylcarbamazine; Author-Supplied Keyword: filariasis; Author-Supplied Keyword: phosphocholine antibodies; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chopra, R.K.
AU  - Powers, D.C.
AU  - Adler, W.H.
AU  - Nagel, J.E.
T1  - Phorbol myristate acetate and calcium ionophore A23187-stimulated human T cells do not express high-affinity IL-2 receptors.
JO  - Immunology
JF  - Immunology
Y1  - 1989/01//
VL  - 66
IS  - 1
M3  - Article
SP  - 54
EP  - 60
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Phorbol myristate acetage (PMA) and Ca2+ ionophore A23187 mimic early signal transduction pathways and activate purified human T cells to secrete large quantities of interleukin-2 (IL-2) and to proliferate. Despite producing 50-100-fold more IL-2 than phytohaemagglutinin (PHA)-activated peripheral blood lymphocytes (PBL), PMA/A23187-stimulated human T cells proliferate less than cells activated by PHA. Washing the cells to remove PMA/A23187 was found to increase cellular proliferation two to five-fold. High-affinity IL-2R (HA-IL-2R) were found to be expressed by human T cells that had been washed 24 hr after PMA/A23187 stimulation and recultured without stimulus for an additional 48 hr, but not by T cells constantly exposed to PMA/A23187 for 72 hr. Radioligand binding studies with [125I]IL-2 demonstrated that while the α (p55) and Β (p70-75) subunits of HA-IL2R were both present on the constant PMA/A23187-stimulated T cells, they did not appear to associate to form functional HA-IL-2R. This defect in the expression of bio-active HA-IL-2R on constant PMA/A23187-stimulated human T cells seems to account for their low proliferative response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHORBOLS
KW  - T cells
KW  - INTERLEUKIN-2
KW  - CELL proliferation
KW  - LYMPHOCYTES
KW  - PHYTOHEMAGGLUTININS
N1  - Accession Number: 13363142; Chopra, R.K. 1 Powers, D.C. 1 Adler, W.H. 1 Nagel, J.E. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, U.S.A.; Source Info: Jan1989, Vol. 66 Issue 1, p54; Subject Term: PHORBOLS; Subject Term: T cells; Subject Term: INTERLEUKIN-2; Subject Term: CELL proliferation; Subject Term: LYMPHOCYTES; Subject Term: PHYTOHEMAGGLUTININS; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mueller, Stephan
AU  - Klaus-Kovtun, Vera
AU  - Stanley, John R.
T1  - A 230-kD Basic Protein Is the Major Bullous Pemphigoid Antigen.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/01//
VL  - 92
IS  - 1
M3  - Article
SP  - 33
EP  - 38
SN  - 0022202X
AB  - Recent studies have demonstrated that bullous pemphigoid (BP) antigen, in extracts of cultured human keratinocytes and normal human epidermis, is a 230-kD polypeptide. However, other recent studies have suggested that there is heterogeneity of EP antigen at the molecular level. To demonstrate that this 230-kD polypeptide is the major BP antigen and to further characterize it, we tested multiple BP sera by both immunoprecipitation of extracts of radiolabeled cultured human keratinocytes and immunoblotting of extracts of normal human epidermis. Thirty-six of 37 BP sera immunoprecipitated the 230-kD polypeptide, and 11 of 13 BP sera identified the 230-kD polypeptide by immunoblotting. Eighty-six disease and normal control sera did not hind the 230-kD BP antigen. Immunoprecipitation was a more sensitive assay than was immunoblotting to detect the 230-kD antigen; BP sera that were weak or negative by immunoblotting were strongly positive by immunoprecipitation. To demonstrate that this 230-kD polypeptide shared epitopes, defined by BP sera, with the epidermal basement membrane zone, we showed that BP IgG affinity purified on this polypeptide bound the epidermal basement membrane zone by immunofluorescence. To further characterize the BP antigen and to compare the antigen synthesized by cultured human keratinocytes to the antigen extracted from epidermis, we analyzed the 230-kD BP antigen by two-dimensional gel electrophoresis. BP antigen immunoprecipitated from culture extracts or HP antigen identified by immunoblots of epidermal extracts was a single spot on two-dimensional gels, with a pI of about 8. These data indicate that, although other polypeptides are sometimes identified (e.g., a 166 kD band by immunoprecipitation or a 180 kD band on immunoblots), the major BP antigen identified in cultured human keratinocytes is similar to the antigen found in normal human epidermis and is a basic 230-kD polypeptide. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - ANTIGENS
KW  - KERATINOCYTES
KW  - EPIDERMIS
KW  - PEPTIDE hormones
KW  - IMMUNOGLOBULINS
KW  - IMMUNOBLOTTING
N1  - Accession Number: 13070476; Mueller, Stephan 1 Klaus-Kovtun, Vera 1 Stanley, John R. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, U.S.A.; Source Info: Jan1989, Vol. 92 Issue 1, p33; Subject Term: PROTEINS; Subject Term: ANTIGENS; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: PEPTIDE hormones; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOBLOTTING; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep13070476
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Tingley, D E
AU  - Oates, G K
AU  - Siegel, E R
T1  - Managing clinical information: what services physicians use, want, and need
JO  - Proceedings of the 52nd Annual Meeting of the American Society for Information Science
JF  - Proceedings of the 52nd Annual Meeting of the American Society for Information Science
Y1  - 1989///
M3  - Conference Paper
SP  - 240
EP  - 240
AB  - These discussions address problems health professionals face regarding the expanding medical knowledge base. Specific issues covered are: how physicians value and use information resources; and an assessment of the impact of the MEDLINE database based on several hundred interviews with end-users. Proceeding Published by Learned Information, United States, 1989
KW  - LIBRARY users
KW  - INFORMATION services
KW  - Healthcare
KW  - Information management
N1  - Accession Number: ISTA2601372; Tingley, D E 1; Oates, G K; Siegel, E R; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: 1989, p240; Note: Place of Publication: United States; Note: Publisher: Learned Information; Note: Update Code: 2600; Note: Conference Title: Proceedings of the 52nd Annual Meeting of the American Society for Information Science; Note: Conference Location: Washington, DC; Note: Conference Dates: November 1989; Subject Term: LIBRARY users; Subject Term: INFORMATION services; Author-Supplied Keyword: Healthcare; Author-Supplied Keyword: Information management; Number of Pages: 1p; Document Type: Conference Paper
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
ID  - 2014-03175-001
AN  - 2014-03175-001
AU  - Brown, Neal B.
T1  - Guest editorial.
T3  - The Community Support System Concept
JF  - Psychosocial Rehabilitation Journal
JO  - Psychosocial Rehabilitation Journal
Y1  - 1989/01//
VL  - 12
IS  - 3
SP  - 1
EP  - 3
CY  - US
PB  - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN  - 0147-5622
N1  - Accession Number: 2014-03175-001. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Brown, Neal B.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Community Services; Mental Disorders; Mental Health Programs; Social Support. Minor Descriptor: Deinstitutionalization; Mental Health. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 3. Issue Publication Date: Jan, 1989. 
AB  - This editorial introduces the community support programs (CSP) for mentally disabled people initiated by National Institute of Mental Health (NIMH) in the year 1974. This program seeks to address the problems resulting from deinstitutionalization and the need for improved community-based services and supports for the mentally disabled. The present issue provide the reader with several views of a CSS, the concept which serves as the basis for all NIMH CSP efforts. The Community Support Program has been successful in a number of ways. The Program has generated a strong network of individuals committed to community support principles. There is good reason to be optimistic about the future of mental health and community support services for persons with long-term mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community support programs
KW  - mentally ill persons
KW  - deinstitutionalization
KW  - mental health
KW  - 1989
KW  - Community Services
KW  - Mental Disorders
KW  - Mental Health Programs
KW  - Social Support
KW  - Deinstitutionalization
KW  - Mental Health
KW  - 1989
DO  - 10.1037/h0099538
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-03175-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09768-001
AN  - 2005-09768-001
AU  - Judd, Lewis L.
T1  - Foreword.
T3  - Report of the U.S. Delegation Soviet Response
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 4, Suppl
SP  - i
EP  - ii
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2005-09768-001. Partial author list: First Author & Affiliation: Judd, Lewis L.; National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Forensic Evaluation; Human Rights; International Relations; Psychiatrists; Psychiatry. Minor Descriptor: Cross Cultural Differences. Classification: Health & Mental Health Treatment & Prevention (3300); Civil Rights & Civil Law (4210). Population: Human (10). Location: USSR; US. Page Count: 2. Issue Publication Date: 1989. 
AB  - The report being discussed here, co-edited by professionals from the U.S. and U.S.S.R., is unique in the history of the National Institute of Mental Health (NIMH) and the 'Schizophrenia Bulletin.' It contains an unusual and historically important dialogue between psychiatric and forensic experts in the United States and the Soviet Union concerning the results of a visit by a Department of State-led Delegation formed to assess recent changes in Soviet psychiatry, particularly those affecting human rights and the forensic system. It documents, as well, the key role of NIMH in providing the scientific expertise and technical support essential to assure the international credibility of the Delegation's findings. In the late 1970s, Soviet allegations of human rights abuses in psychiatry led to a suspension of scientific exchange between the U.S. and the U.S.S.R. in the area of brain sciences and mental illness. Clearly, a strengthening of human rights protections in psychiatry and many other aspects of Soviet life, is a prerequisite to the resumption of such exchange. As an outgrowth of the largely positive Soviet response to the Delegation's visit and its report, a limited professional visit related to psychiatric and forensic practice is underway. The Department of State is sponsoring this visit in early 1990 to expose Soviet psychiatrists and forensic experts to current U.S. approaches to psychiatric diagnosis and treatment, service delivery, and forensic psychiatric practices. This journal has identical articles written in Russian and English. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - forensic experts
KW  - professional visits
KW  - service delivery
KW  - human right abuses
KW  - Soviet psychiatry
KW  - American Delegation
KW  - scientific expertise
KW  - technical support
KW  - 1989
KW  - Forensic Evaluation
KW  - Human Rights
KW  - International Relations
KW  - Psychiatrists
KW  - Psychiatry
KW  - Cross Cultural Differences
KW  - 1989
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06494-016
AN  - 2006-06494-016
AU  - Friedman, Sarah L.
T1  - The Development of Social Cognition: Novel, Familiar, and Missing Snapshots.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1989/01//
VL  - 34
IS  - 1
SP  - 25
EP  - 28
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06494-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Friedman, Sarah L.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Child Psychology; Childhood Development; Social Behavior; Social Cognition. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Perlmutter, Marion (Ed). Cognitive Perspectives on Children's Social and Behavioral Development: The Minnesota Symposium on Child Psychology, Vol. 18=Hillsdale, NJ: Erlbaum, 1986. 344 pp. $34.95; 1986. References Available: Y. Page Count: 4. Issue Publication Date: Jan, 1989. 
AB  - Reviews the book, Cognitive Perspectives on Children's Social and Behavioral Development: The Minnesota Symposium on Child Psychology, Vol. 18 by Marion Perlmutter (Ed.) (1986). This volume provides snapshots of topics, concepts, research methods, and findings directly or indirectly related to the study of the development of social cognition. This volume focuses on cognitive perspectives that may usefully inform the study of social behavior and development. These perspectives are both theoretical and methodological. The cognitive perspectives that Fischer and Elmendorf bring to the study of social cognition are both methodological and explanatory. Finally, the volume features a cognitive perspective about children's understanding of control, the capacity to cause intended events. In summary, the volume is rich in interesting ideas and findings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - behavioral development
KW  - social development
KW  - child psychology
KW  - social cognition
KW  - 1989
KW  - Child Psychology
KW  - Childhood Development
KW  - Social Behavior
KW  - Social Cognition
KW  - 1989
U2  - Perlmutter, Marion (Ed). (1986); Cognitive Perspectives on Children's Social and Behavioral Development: The Minnesota Symposium on Child Psychology, Vol. 18; Hillsdale, NJ: Erlbaum, 1986. 344 pp. $34.95; 0-89859-546-0.
DO  - 10.1037/027528
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06494-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09722-005
AN  - 2005-09722-005
AU  - Rosenstein, Marilyn J.
AU  - Milazzo-Sayre, Laura J.
AU  - Manderscheid, Ronald W.
T1  - Care of Persons With 45 Schizophrenia: A Statistical Profile.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 1
SP  - 45
EP  - 58
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Manderscheid, Ronald W., Survey and Reports Branch, DBAS, NIMH, Rm. 18C-07, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09722-005. PMID: 2717889 Partial author list: First Author & Affiliation: Rosenstein, Marilyn J.; Survey and Reports Branch, Division of Biometry and Applied Sciences, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Mental Health; Mental Health Programs; Mental Health Services; Schizophrenia. Minor Descriptor: Outpatients. Classification: Schizophrenia & Psychotic States (3213); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 1989. 
AB  - This article presents the latest information available from the National Reporting Program for Mental Health Statistics on the distribution and characteristics of persons with schizophrenia served by organized, specialty inpatient, outpatient, and partial care mental health programs. Results are presented separately for persons under care at one point in time and for persons admitted over a 1-year period, in order to examine the potential for change in each type of care. Findings show that about 900,000 persons with schizophrenia were served in 1986; that inpatient and outpatient programs were relatively equivalent in total numbers served, but that considerably more patient turnover occurred in inpatient programs; and that partial care programs, although small, were evolving as a locus of care for persons with schizophrenia. Some variations were observed among the different types of organizations offering each type of care, and characteristics of clients/patients that could lead to changes in each type of care were evident. Overall, the findings present a useful composite picture of specialty mental health care for persons with schizophrenia. The need for longitudinal, prospective research is noted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - mental health care
KW  - mental health programs
KW  - 1989
KW  - Health Care Services
KW  - Mental Health
KW  - Mental Health Programs
KW  - Mental Health Services
KW  - Schizophrenia
KW  - Outpatients
KW  - 1989
DO  - 10.1093/schbul/15.1.45
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09722-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09722-014
AN  - 2005-09722-014
AU  - Lyon, Melvin
AU  - Barr, Chris E.
AU  - Cannon, Tyrone D.
AU  - Mednick, Sarnoff A.
AU  - Shore, David
T1  - Fetal Neural Development and Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 1
SP  - 149
EP  - 160
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Lyon, Melvin, Social Science Research Institute, USC, Los Angeles, CA, US, 90089-1111
N1  - Accession Number: 2005-09722-014. Partial author list: First Author & Affiliation: Lyon, Melvin; Social Science Research Institute, University of Southern California, Los Angeles, CA, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Amygdala; Basal Ganglia; Hippocampus; Neural Development; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: 1989. 
AB  - The conference on Fetal Neural Development and Schizophrenia which was held in Washington, DC, May 31-June 1, 1988, focused on factors of possible etiological significance in fetal development. Schizophrenia researchers joined experts in brain imaging, neuropathological, and neurochemical changes in brain development and investigators of potential genetic and neurobehavioral causes of psychosis. The combined evidence suggested dysfunction in frontal and parieto-occipital neocortex, basal ganglia, hippocampus, and amygdala. Dopamine transmission was implicated both in basal ganglia deficits and in widespread neocortical disturbances. Viral infection, or excessive stress, during the second trimester of pregnancy, as well as obstetrical complications, minor physical anomalies, and brain defects, correlated positively with incidence of adult schizophrenia. Autonomic nonresponding, birth complications, and ventricular enlargement were found to be closely related to negative symptom schizophrenia in high-risk populations. A dual factor model of schizophrenia was suggested, where genetic and environmental influences combine to produce psychosis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - fetal neural development
KW  - schizophrenia
KW  - basal ganglia
KW  - amygdala
KW  - hippocampus
KW  - 1989
KW  - Amygdala
KW  - Basal Ganglia
KW  - Hippocampus
KW  - Neural Development
KW  - Schizophrenia
KW  - 1989
DO  - 10.1093/schbul/15.1.149
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09722-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09776-003
AN  - 2005-09776-003
AU  - Schulz, S. Charles
AU  - Pato, Carlos N.
T1  - Advances in the Genetics of Schizophrenia: Editors' Introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 3
SP  - 361
EP  - 363
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Pato, Carlos N., Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09776-003. PMID: 2573148 Partial author list: First Author & Affiliation: Schulz, S. Charles; Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20060227. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Genetics; Schizophrenia. Minor Descriptor: Genetic Linkage. Classification: Research Methods & Experimental Design (2260); Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1989. 
AB  - In view of the rapid advances in the application of molecular genetics to research in schizophrenia, an effort was made to put these studies into a wider perspective. This issue of the Schizophrenia Bulletin is devoted to the expanded presentation of some of the early genetic linkage findings in schizophrenia, and a broader discussion of the impact of these new techniques on schizophrenia research, as well as the limitations of this approach in a complex disorder. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - molecular genetics
KW  - schizophrenia research
KW  - genetic advancement
KW  - schizophrenia
KW  - genetic linkage
KW  - 1989
KW  - Experimentation
KW  - Genetics
KW  - Schizophrenia
KW  - Genetic Linkage
KW  - 1989
DO  - 10.1093/schbul/15.3.361
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09776-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09776-004
AN  - 2005-09776-004
AU  - Pato, Carlos N.
AU  - Lander, Eric S.
AU  - Schulz, S. Charles
T1  - Prospects for the Genetic Analysis of Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 3
SP  - 365
EP  - 372
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Pato, Carlos N., Genetics Research Program, Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09776-004. PMID: 2683037 Partial author list: First Author & Affiliation: Pato, Carlos N.; Genetics Research Program, Schizophrenia Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20060227. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Genetic Linkage; Genetics; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: 1989. 
AB  - This issue of the Schizophrenia Bulletin provides a forum for the presentation of early results and speculative hypotheses based on the application of molecular genetic methods for linkage studies in schizophrenia. Contributors were given the freedom to explore the historical and theoretical perspectives on the genetics of schizophrenia. They were also asked to balance their enthusiasm and cautious skepticism at the new suggestions of linkage involving chromosome 5 (Sherrington et al. 1988). In this overview, the epidemiologic evidence for a genetic factor in schizophrenia and recent linkage studies are briefly discussed. In addition, the potential and limitations of different linkage strategies in schizophrenia are examined. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - genetic linkage analysis
KW  - molecular genetic methods
KW  - theoretical perspectives
KW  - historical perspectives
KW  - epidemiologic evidence
KW  - 1989
KW  - Epidemiology
KW  - Genetic Linkage
KW  - Genetics
KW  - Schizophrenia
KW  - 1989
DO  - 10.1093/schbul/15.3.365
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09776-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09760-002
AN  - 2005-09760-002
AU  - Keith, Samuel J.
AU  - Regier, Darrel A.
T1  - U.S. and Soviet perspectives on the diagnosis of schizophrenia and associated dangerousness.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 4
SP  - 515
EP  - 517
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Keith, Samuel J., Division of Clinical Research, National Institute of Mental Health, Parklawn Bldg., Rm. 10-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09760-002. PMID: 2623436 Partial author list: First Author & Affiliation: Keith, Samuel J.; Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Dangerousness; Diagnosis; Mental Disorders; Schizophrenia. Minor Descriptor: Psychiatric Patients; Role Taking. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: Russia; US. References Available: Y. Page Count: 3. Issue Publication Date: 1989. 
AB  - During a visit of U.S. senior mental health and forensic experts to the Soviet Union to assess recent changes in Soviet psychiatry, a symposium was held to discuss the U.S. and Soviet concepts of the diagnosis of schizophrenia and dangerousness associated with psychiatric illness. The basic conclusion from this exchange was that significant differences exist between the countries in both areas, as the U.S. conceptualization of schizophrenia and associated dangerousness is considerably narrower than that of Soviet practice. Clearly, future scientific exchange is warranted to examine these conceptual differences in an effort to establish a better empirical basis for assessing the most appropriate medical treatment and legal disposition for patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - US perspective
KW  - Soviet perspective
KW  - schizophrenia diagnosis
KW  - psychiatric illness dangerousness
KW  - 1989
KW  - Cross Cultural Differences
KW  - Dangerousness
KW  - Diagnosis
KW  - Mental Disorders
KW  - Schizophrenia
KW  - Psychiatric Patients
KW  - Role Taking
KW  - 1989
DO  - 10.1093/schbul/15.4.515
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09760-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09760-005
AN  - 2005-09760-005
AU  - Monahan, John
AU  - Shah, Saleem A.
T1  - Dangerousness and Commitment of the Mentally Disordered in the United States.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1989///
VL  - 15
IS  - 4
SP  - 541
EP  - 553
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Monahan, John, NIMH, Parklawn Bldg., Room 18-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09760-005. PMID: 2696085 Partial author list: First Author & Affiliation: Monahan, John; University of Virginia, Charlottesville, VA, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Commitment (Psychiatric); Laws; Mental Disorders; Mentally Ill Offenders. Minor Descriptor: Dangerousness. Classification: Psychological Disorders (3210); Forensic Psychology & Legal Issues (4200). Population: Human (10). Location: US. Tests & Measures: National Institute of Mental Health Survey. Methodology: Empirical Study. References Available: Y. Page Count: 13. Issue Publication Date: 1989. 
AB  - This article describes recent developments in mental health laws in the United States, especially as they relate to uses of the concept of 'dangerousness' in the civil and criminal commitment of the mentally ill. In addition to providing a brief overview of the U.S. legal system and noting the importance of the Rule of Law, we review the historical development and current status of the relevant laws, provide some basic epidemiological statistics, and refer to some of the considerable body of extant empirical research in the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mentally disordered
KW  - mental health laws
KW  - criminal commitment
KW  - dangerousness
KW  - civil commitment
KW  - US legal system
KW  - epidemiology
KW  - 1989
KW  - Commitment (Psychiatric)
KW  - Laws
KW  - Mental Disorders
KW  - Mentally Ill Offenders
KW  - Dangerousness
KW  - 1989
DO  - 10.1093/schbul/15.4.541
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09760-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09117-001
AN  - 2008-09117-001
AU  - Kelty, Miriam F.
AU  - Hastings, Margaret M.
AU  - Cahn, Jerry
AU  - Kaplan, Robert M.
AU  - Curbow, Barbara
AU  - Bransfield, Diana D.
AU  - Gallant, Sheryle J. A.
AU  - DeLeon, Patrick
AU  - Bryant, Patricia
AU  - Wickram, Ian
AU  - Millstein, Susan G.
T1  - Health policy.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1989///
VL  - 8
IS  - 6
SP  - 773
EP  - 775
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
AD  - Kelty, Miriam F., National Institute on Aging, National Institutes of Health, Room 5C-06, Building 31, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-09117-001. PMID: 2637865 Partial author list: First Author & Affiliation: Kelty, Miriam F.; National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior; Health; Health Care Policy. Minor Descriptor: Behavioral Sciences; Government Policy Making; Legislative Processes; Private Sector; Professional Organizations. Classification: Promotion & Maintenance of Health & Wellness (3365); Political Processes & Political Issues (2960). Population: Human (10). Page Count: 3. Issue Publication Date: 1989. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1989. 
AB  - The charge to the task force on health policy was to consider policy relevant to health and behavior. Legislative initiatives, private sector initiatives, and the interface among professional societies were addressed. More specifically, the task force discussed ways in which research must be conducted and presented to maximize its usefulness to policy makers, areas of interface between the behavioral sciences and health policy, and methods of training scientists to be more effective in shaping policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - health policy
KW  - health
KW  - behavior
KW  - legislative initiatives
KW  - private sector initiatives
KW  - professional societies
KW  - behavioral sciences
KW  - 1989
KW  - Behavior
KW  - Health
KW  - Health Care Policy
KW  - Behavioral Sciences
KW  - Government Policy Making
KW  - Legislative Processes
KW  - Private Sector
KW  - Professional Organizations
KW  - 1989
DO  - 10.1037/h0090322
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09117-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09118-001
AN  - 2008-09118-001
AU  - Drotar, Dennis
AU  - Johnson, Suzanne Bennett
AU  - Iannotti, Ron
AU  - Krasnegor, Norman
AU  - Matthews, Karen A.
AU  - Melamed, Barbara G.
AU  - Millstein, Sharon
AU  - Peterson, Rolf A.
AU  - Popiel, Debbie
AU  - Routh, Donald K.
T1  - Child health psychology.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1989///
VL  - 8
IS  - 6
SP  - 781
EP  - 784
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
AD  - Drotar, Dennis, Department of Psychiatry, Metro Health Medical Center, 3395 Scranton Road, Cleveland, OH, US, 44109
N1  - Accession Number: 2008-09118-001. PMID: 2637867 Partial author list: First Author & Affiliation: Drotar, Dennis; Case Western Reserve University School of Medicine, Cleveland, OH, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Psychology; Childhood Development; Developmental Psychology; Experimentation; Health Care Psychology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 4. Issue Publication Date: 1989. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1989. 
AB  - [Correction Notice: An erratum for this article was reported in Vol 9(6) of Health Psychology (see record [rid]2008-09119-001[/rid]). The name of the author, Sharon Millstein, should be Susan Millstein.] The term child health psychology refers to the field of research on the behavioral aspects of children's health and illness. At this time we need to continue the work of the child health psychology special interest group and to draw into the Division of Health Psychology a much larger number of developmental psychologists, who need to be informed about the relevance of their scientific training to child health issues. We call the Division's attention and that of granting agencies such as the National Institute of Child Health and Human Development to the following high-priority child health research issues: adherence to pediatric medical regimens; child health promotion; family influences on child and adolescent health and disease; and stress and coping in childhood illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child health psychology
KW  - developmental psychology
KW  - child health research
KW  - 1989
KW  - Child Psychology
KW  - Childhood Development
KW  - Developmental Psychology
KW  - Experimentation
KW  - Health Care Psychology
KW  - 1989
DO  - 10.1037/h0090323
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09118-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2016-09459-001
AN  - 2016-09459-001
AU  - Brott, Thomas
AU  - Adams, Harold P. Jr.
AU  - Olinger, Charles P.
AU  - Marle, John R.
AU  - Barsan, William G.
AU  - Biller, José
AU  - Spilker, Judith
AU  - Holleran, Renée
AU  - Eberle, Robert
AU  - Hertzberg, Vicki
AU  - Rorick, Marvin
AU  - Moomaw, Charles J.
AU  - Walker, Michael
T1  - Measurements of acute cerebral infarction: A clinical examination scale.
JF  - Stroke
JO  - Stroke
JA  - Stroke
Y1  - 1989/01//
VL  - 20
IS  - 7
SP  - 864
EP  - 870
CY  - US
PB  - American Heart Association
SN  - 0039-2499
SN  - 1524-4628
AD  - Brott, Thomas, Department of Neurology, University of Cincinnati Medical Center, 231 Bethesda Avenue, Cincinnati, OH, US, 45267-0525
N1  - Accession Number: 2016-09459-001. PMID: 2749846 Partial author list: First Author & Affiliation: Brott, Thomas; Department of Neurology, University of Cincinnati, Cincinnati, OH, US. Release Date: 20160229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Hemorrhage; Psychometrics; Test Reliability. Minor Descriptor: Achievement Measures. Classification: Clinical Psychological Testing (2224); Neurological Disorders & Brain Damage (3297). Population: Human (10). Tests & Measures: Toronto Stroke Scale; Oxbury Initial Severity Scale; Cincinnati Stroke Scale; Edinburgh-2 Coma Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 1989. Publication History: Accepted Date: Jan 9, 1989; First Submitted Date: Nov 7, 1988. 
AB  - We designed a 15-item neurologic examination stroke scale for use in acute stroke therapy trials. In a study of 24 stroke patients, interrater reliability for the scale was found to be high (mean κ = 0.69), and test-retest reliability was also high (mean κ = 0.66-0.77). Test-retest reliability did not differ significantly among a neurologist, a neurology house officer, a neurology nurse, or an emergency department nurse. The stroke scale validity was assessed by comparing the scale scores obtained prospectively on 65 acute stroke patients to the patients' infarction size as measured by computed tomography scan at 1 week and to the patients' clinical outcome as determined at 3 months. These correlations (scale-lesion size r = 0.68, scale-outcome r = 0.79) suggested acceptable examination and scale validity. Of the 15 test items, the most interrater reliable item (pupillary response) had low validity. Less reliable items such as upper or lower extremity motor function were more valid. We discuss methods for improving the reliability and validity of brief examination scales to be used in stroke therapy trials. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - acute cerebral infarction
KW  - test reliability
KW  - psychometrics
KW  - clinical examination scale
KW  - 1989
KW  - Cerebral Hemorrhage
KW  - Psychometrics
KW  - Test Reliability
KW  - Achievement Measures
KW  - 1989
U1  - Sponsor: United States Public Health Service, National Institutes of Health, National Institute of Neurological Disorders and Stroke, US. Grant: N01-NS-2324; N01-NS-2326. Other Details: TO 1 (University of Cincinnati), TO 1 (University of Iowa). Recipients: No recipient indicated
DO  - 10.1161/01.STR.20.7.864
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2016-09459-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Cone, Edward J.
AU  - Henningfield, Jack E.
AU  - Cone, E J
AU  - Henningfield, J E
T1  - Premier 'smokeless cigarettes' can be used to deliver crack.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/01/06/
VL  - 261
IS  - 1
M3  - letter
SP  - 41
EP  - 41
SN  - 00987484
AB  - Presents a letter to the editor of the January 6, 1989 issue of the 'Journal of the American Medical Association,' regarding the commercial introduction into the U.S. market of the Premier smokeless cigarette of R.J. Reynolds Tobacco Co.
KW  - SMOKELESS tobacco
KW  - LETTERS to the editor
KW  - COCAINE
KW  - SMOKING
KW  - SUBSTANCE abuse
KW  - PRODUCT design
KW  - UNITED States
KW  - R.J. Reynolds Tobacco Co.
N1  - Accession Number: 10949514; Cone, Edward J. 1 Henningfield, Jack E. 1 Cone, E J Henningfield, J E; Affiliation:  1: National Institute on Drug Abuse, Baltimore; Source Info: 1/6/89, Vol. 261 Issue 1, p41; Subject Term: SMOKELESS tobacco; Subject Term: LETTERS to the editor; Subject Term: COCAINE; Subject Term: SMOKING; Subject Term: SUBSTANCE abuse; Subject Term: PRODUCT design; Subject Term: UNITED States; Company/Entity: R.J. Reynolds Tobacco Co.; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 541420 Industrial Design Services; Number of Pages: 1p; Document Type: letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - From the National Institutes of Health.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/01/13/
VL  - 261
IS  - 2
M3  - Article
SP  - 200
EP  - 200
SN  - 00987484
AB  - Provides information provided by the U.S. National Institutes of Health on issues affecting the health of black Americans, as of January 1989.  Prevalence of diabetes in black Americans; Evidence showing that black Americans have the higher age-adjusted incidence and mortality rates for several cancers; Incidence of low birth weight in urban black populations.
KW  - AFRICAN Americans -- Health
KW  - PUBLIC health
KW  - DIABETES
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 10949566; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 1/13/89, Vol. 261 Issue 2, p200; Subject Term: AFRICAN Americans -- Health; Subject Term: PUBLIC health; Subject Term: DIABETES; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Staddon, James M.
AU  - Hansford, Richard G.
T1  - Evidence indicating that the glucagon-induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/01/15/
VL  - 179
IS  - 1
M3  - Article
SP  - 47
EP  - 52
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The mechanism whereby glucagon causes an increase in the concentration of cytoplasmic free Ca2+, [Ca2+]c, in isolated hepatocytes has been investigated. There have been proposals of cyclic-AMP-dependent and cyclicAMP-independent mechanisms. In this work, the inactivation of pyruvate kinase was used as an indicator of increases in the activity of cyclic-AMP-dependent protein kinase, A-kinase. [Ca2+]c was measured using the fluorescent probe indo-1. The decrease in activity of pyruvate kinase caused by an increase in [Ca2+]c alone, i.e. mediated by mechanisms not involving cyclic AMP and exemplified by the effect of vasopressin, was of minimal significance under the conditions of the enzyme assay. Studies of the effects of a wide range of glucagon concentrations indicate that any increase in [Ca2+]c caused by glucagon was always associated with a decrease in pyruvate kinase activity. A similar relationship was obtained if glucagon-receptor occupancy was circumvented by using the 8-bromo-derivative of cyclic AMP to activate the A-kinase. It was also found that the cyclic AMP phosphodiesterase inhibitor isobutylmethylxanthine could potentiate the ability of glucagon to increase ICa2+]c: no such potentiation was observed when vasopressin was used to raise [Ca2+]c. Together these data indicate that an increase in cyclic AMP concentration, sufficiently great to activate A-kinase, is a mechanism that mediates the glucagon-induced increase in [Ca2+]c. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUCAGON
KW  - PANCREATIC secretions
KW  - PEPTIDE hormones
KW  - ADENYLIC acid
KW  - BIOCHEMISTRY
KW  - MOLECULAR biology
N1  - Accession Number: 13746880; Staddon, James M. 1 Hansford, Richard G. 1; Affiliation:  1: National Institutes of Health, Gerontology Research Center, Baltimore, Maryland; Source Info: 1/15/89, Vol. 179 Issue 1, p47; Subject Term: GLUCAGON; Subject Term: PANCREATIC secretions; Subject Term: PEPTIDE hormones; Subject Term: ADENYLIC acid; Subject Term: BIOCHEMISTRY; Subject Term: MOLECULAR biology; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sandler, Dale P.
AU  - Comstock, George W.
AU  - Helsing, Knud J.
AU  - Shore, David L.
T1  - Deaths from All Causes in Non-Smokers Who Lived with Smokers.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/02//
VL  - 79
IS  - 2
M3  - Article
SP  - 163
EP  - 167
PB  - American Public Health Association
SN  - 00900036
AB  - Mortality associated with passive smoking was evaluated in a 12-year study of 27,891 White adult smokers and 19,035 never smokers identified in 1963. Death rates were calculated using an estimate of the person-years at risk. Adjusted for age, marital status, education, and quality of housing, the estimated relative risks of death from all causes were 1.17 (approximate 95% confidence interval 1.01, 1.36) for men and 1.15 (1.06, 1.24) for women with passive exposure. These relative risks were similar to those for ex-smokers and for pipe or cigar smokers. Risks increased slightly with level of exposure. The relative risk from passive smoking was greatest for men under age 50 (RR = 2.09, 1.31-3.34). Risks from passive smoking were slightly elevated for several causes among men and women, and may be broader than those previously reported. On the other hand, these small nonspecific increases in death rates may reflect other characteristics of passive smokers that increase mortality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PASSIVE smoking
KW  - RESEARCH
KW  - SMOKING
KW  - MORTALITY
KW  - MORTALITY -- Statistics
KW  - CIGARETTE smokers
KW  - MORTALITY -- Tables
KW  - STATISTICAL hypothesis testing
N1  - Accession Number: 4682714; Sandler, Dale P. 1 Comstock, George W. 2 Helsing, Knud J. 2 Shore, David L. 1; Affiliation:  1: Epidemiology Branch, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences  2: Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health; Source Info: Feb1989, Vol. 79 Issue 2, p163; Subject Term: PASSIVE smoking; Subject Term: RESEARCH; Subject Term: SMOKING; Subject Term: MORTALITY; Subject Term: MORTALITY -- Statistics; Subject Term: CIGARETTE smokers; Subject Term: MORTALITY -- Tables; Subject Term: STATISTICAL hypothesis testing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nagel, J. E.
AU  - Chopra, R. K.
AU  - Powers, D. C.
AU  - Adler, W. H.
T1  - Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1989/02//
VL  - 75
IS  - 2
M3  - Article
SP  - 286
EP  - 291
PB  - Wiley-Blackwell
SN  - 00099104
AB  - High affinity interleukin 2 receptors (HA-IL-2R) on mitogen-or antigen-stimulated T cells have been shown to efficiently bind interleukin 2 (IL-2) and to transduce the activation signal(s) that facilitate proliferation. This study was initiated to determine whether the impaired proliferative response of T cells from elderly individuals can be attributed to the defective expression of HA-IL-2R. While cells from both young and old individuals had statistically insignificant differences in the number of HA-IL-2R per membrane IL-2R-positive cell and these receptors displayed similar binding affinities with 125-IL-2, there were consistently fewer cells and fewer cells expressing HA-IL-2R in the cell cultures from elderly individuals. The magnitude of the age-associated impairment in cell proliferation was decreased, but remained present, when Percoll fractionated lymphoblasts, as compared to peripheral blood lymphocytes (PBL), were cultured in the presence of exogenous interleukin 2 (IL-2). The results demonstrate that a significantly larger percentage of lymphocytes from elderly individuals do not respond to mitogenic stimulation and, probably due to stimulus stress, die in culture. As a consequence there are fewer functionally competent cells expressing the HA-IL-2R in cultures from elderly individuals, which in turn contributes to the age-related defect in the lymphocyte proliferative response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - ANTIGENS
KW  - T cells
KW  - CELL culture
KW  - LYMPHOCYTES
KW  - CELL proliferation
KW  - aging
KW  - interleukin 2
KW  - interleukin 2 receptor
N1  - Accession Number: 16159086; Nagel, J. E. 1 Chopra, R. K. 1 Powers, D. C. 1 Adler, W. H. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute On Aging, National Institutes of Health, Baltimore, MD 21224.; Source Info: Feb1989, Vol. 75 Issue 2, p286; Subject Term: INTERLEUKIN-2; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: CELL culture; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Author-Supplied Keyword: aging; Author-Supplied Keyword: interleukin 2; Author-Supplied Keyword: interleukin 2 receptor; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yancey, Kim B.
AU  - Lawley, Thomas J.
AU  - Dersookian, Mirra
AU  - Harvath, Liana
T1  - Analysis of the Interaction of Human C5a and C5a des Arg with Human Monocytes and Neutrophils: Flow Cytometric and Chemotaxis Studies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/02//
VL  - 92
IS  - 2
M3  - Article
SP  - 184
EP  - 189
SN  - 0022202X
AB  - C5a and C5a des Arg are potent complement-derived mediators that bind receptors on peripheral blood leukocytes and tissue-specific cellular elements to elicit and amplify inflammatory and immunomodulatory reactions. To study the interactions of C5a and C5a des Arg with these cells, fluorescein conjugates of these ligands were prepared by a new technique and their binding to monocytes, neutrophils, platelets, and endothelial cells was studied with flow cytometry. Fluoresceinated C5a produced neutrophil myeloperoxidase release and chemotaxis and also bound rabbit anti-C5a antibody much like native anaphylatoxin; likewise, fluoresceinated C5a des Arg demonstrated retention of biologic and antigenic activities. Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes. Ligand binding was specifically inhibited by native purified human C5a in a concentration-dependent manner, while it was unaffected by C3a or N-formyl-methionyl- leucylphenylalanine-lysine. There was no evidence of a C5a receptor-negative subpopulation of monocytes or neutrophils. Moreover, comparative binding experiments with leukocytes from multiple normal volunteers showed that a greater percentage of monocytes than neutrophils bound C5a at less than saturable concentrations of ligand (P < 0.05, 0.5 to 5.0 nM). A representative half-maximal binding of fluorescein-conjugated C5a (C5a des Arg) binding to monocytes and neutrophils was 1.2 nM (30 nM) and 2.6 nM (68 nM), respectively. In contrast, fluorescein-conjugated C5a did not specifically bind to human platelets or umbilical vein endothelial cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCYTES
KW  - NEUTROPHILS
KW  - CHEMOTAXIS
KW  - LEUCOCYTES
KW  - FLUORESCEIN
KW  - CYTOMETRY
N1  - Accession Number: 12276710; Yancey, Kim B. 1 Lawley, Thomas J. 2 Dersookian, Mirra 1 Harvath, Liana 3; Affiliation:  1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.  2: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland.  3: Division of Blood and Blood Products, Office of Biologics Research and Review, Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Feb89, Vol. 92 Issue 2, p184; Subject Term: MONOCYTES; Subject Term: NEUTROPHILS; Subject Term: CHEMOTAXIS; Subject Term: LEUCOCYTES; Subject Term: FLUORESCEIN; Subject Term: CYTOMETRY; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12276710
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jetten, Anton M.
AU  - George, Margaret A.
AU  - Nervi, Clara
AU  - Boone, Lawrence R.
AU  - Rearick, James I.
T1  - Increased Cholesterol Sulfate and Cholesterol Sulfotransferase Activity in Relation to the Multi-step Process of Differentiation in Human Epidermal Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/02//
VL  - 92
IS  - 2
M3  - Article
SP  - 203
EP  - 209
SN  - 0022202X
AB  - In this study the synthesis of cholesterol sulfate is examined in relation to the process of squamous differentiation in normal human epidermal keratinocytes (NHEK) in culture. During the exponential growth phase, NHEK cells exhibit a relatively high colony-forming efficiency and appear undifferentiated on the basis of their morphology and expression of biochemical characteristics. At confluence, the cells undergo terminal differentiation that is characterized by the commitment to terminal cell division (reduction in colony-forming ability) and expression of the differentiated phenotype. An accumulation of cholesterol sulfate accompanies this program of differentiation. This accumulation of cholesterol sulfate parallels the increase in transglutaminase type I activity and the competence to form cross-linked envelopes, whereas it precedes the "spontaneous" formation of cross-linked envelopes. Increased cholesterol sulfotransferase activity appears to account for the increase in cholesterol sulfate. The cholesterol sulfate accumulation, as well as the increase in cholesterol sulfotransferase and transglutaminase activity, are inhibited by retinoids. However, the presence of retinoids does not prevent NHEK cells from undergoing terminal cell division at confluence. Two NHEK cell lines expressing SV40-large T antigen also undergo terminal differentiation at confluence and start to accumulate cholesterol sulfate. Two other, differentiation-defective cell lines do not exhibit an increase in cholesterol sulfate at confluence. These results show that epidermal keratinocytes in culture, like cells in the epidermis, accumulate cholesterol sulfate when undergoing squamous differentiation. This program appears to consist of a retinoid-insensitive step (commitment to terminal cell division) and a retinoid-sensitive step (expression of the squamous differentiated phenotype). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHOLESTEROL
KW  - KERATINOCYTES
KW  - TRANSFERASES
KW  - TRANSGLUTAMINASES
KW  - RETINOIDS
KW  - EPIDERMIS
N1  - Accession Number: 12276731; Jetten, Anton M. 1 George, Margaret A. 1 Nervi, Clara 1 Boone, Lawrence R. 2 Rearick, James I. 3; Affiliation:  1: Cell Biology Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S..A.  2: Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S..A.  3: Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, Missouri, U.S.A.; Source Info: Feb89, Vol. 92 Issue 2, p203; Subject Term: CHOLESTEROL; Subject Term: KERATINOCYTES; Subject Term: TRANSFERASES; Subject Term: TRANSGLUTAMINASES; Subject Term: RETINOIDS; Subject Term: EPIDERMIS; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12276731
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Creek, Kim E.
AU  - Silverman-Jones, Carol S.
AU  - de Luca, Luigi M.
T1  - Comparison of the Uptake and Metabolism of Retinol Delivered to Primary Mouse Keratinocytes Either Free or Bound to Rat Serum Retinol-binding Protein.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/02//
VL  - 92
IS  - 2
M3  - Article
SP  - 283
EP  - 289
SN  - 0022202X
AB  - Serum retinol-binding protein (RBP) is believed to be responsible for the transport of retinol from its storage site in the liver to vitamin A requiring target cells such as keratinocytes. We have used primary mouse keratinocytes as a model system to compare the uptake and metabolism of [3H] retinol delivered to them either free in solution or bound to RBP. RBP was purified from rat serum, loaded with [3H]retinol, and the [3H]retinol-RBP complex purified by affinity chromatography on human transthyretin-Sepharose. Keratinocytes incubated with either free [3H]retinol or [3H]retinal-RBP complex accumulated [3H]retinol in a time and temperature dependent manner, However, cells incubated with free [3H]retinol acquired 15- to 20-fold more ligand than if the retinol was delivered via RBP. The uptake of free [3H]retinol or [3H]retinol from RBP was not inhibited by excess unlabeled free retinol. The uptake of [3H]retinol from RBP was inhibited by high concentrations of holo-RBP, with half maximal inhibition occurring at 3μM holo-RBP. However, no specific binding of 125I-labeled RBP to monolayers of keratinocytes or membranes prepared from them was found indicating the absence of a high affinity RBP receptor on keratinocytes. Surprisingly, 50% of the [3H]retinol delivered to the keratinocytes during a 30-min uptake period was released from them within 30-min irrespective of whether or not it was initially delivered to them as free [3H]retinol or bound to RBP. The remaining 50% was lost at a much slower rate, but only 20% remained 24-h after delivery. Studies on retinol metabolism demonstrated that 7%12% of the total cell-associated [3H]retinol delivered during a 90-min uptake period was esterified (mostly as retinyl palmitate) whether or not it was given free in solution or bound to RBP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VITAMIN A
KW  - KERATINOCYTES
KW  - SERUM
KW  - SEPHAROSE
KW  - METABOLISM
KW  - TRETINOIN
N1  - Accession Number: 12276867; Creek, Kim E. 1 Silverman-Jones, Carol S. 1 de Luca, Luigi M. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A; Source Info: Feb89, Vol. 92 Issue 2, p283; Subject Term: VITAMIN A; Subject Term: KERATINOCYTES; Subject Term: SERUM; Subject Term: SEPHAROSE; Subject Term: METABOLISM; Subject Term: TRETINOIN; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12276867
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cain, Virginia S.
AU  - Hofferth, Sandra L.
T1  - Parental Choice of Self-care for School-Age Children.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1989/02//
VL  - 51
IS  - 1
M3  - Article
SP  - 65
EP  - 77
SN  - 00222445
AB  - This article provides national estimates from the December 1984 Current Population Survey of the number of school-age children who, in the past four weeks, had been in self-care or in the care of a sibling or other person under the age of 14 either before school, after school, or at night. A logit model is then used to analyze, first, the use of nonparental care and, second, the choice of self-care for their children by parents who use nonparental care. The results suggest that self-care is more likely to be used by middle- and upper-income white mothers living in suburban or rural areas, with no other adults in the household, for older children, and for only a short time each day, than by other mothers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD care
KW  - SCHOOL children
KW  - BROTHERS & sisters
KW  - MOTHERS
KW  - FAMILIES
KW  - Child Care and Welfare Services
KW  - CHILD WELFARE, PROBLEMS, AND TREATMENT
KW  - LATCHKEY CHILDREN
N1  - Accession Number: 5273866; Cain, Virginia S. 1 Hofferth, Sandra L. 2; Affiliation:  1: National Institute of Child Health and Human Development  2: Urban Institute; Source Info: Feb89, Vol. 51 Issue 1, p65; Subject Term: CHILD care; Subject Term: SCHOOL children; Subject Term: BROTHERS & sisters; Subject Term: MOTHERS; Subject Term: FAMILIES; Author-Supplied Keyword: Child Care and Welfare Services; Author-Supplied Keyword: CHILD WELFARE, PROBLEMS, AND TREATMENT; Author-Supplied Keyword: LATCHKEY CHILDREN; Number of Pages: 13p; Illustrations: 7 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Teti, Douglas M.
AU  - Lamb, Michael E.
T1  - Socioeconomic and marital Outcomes of Adolescent Marriage, Adolescent Childbirth, and Their Co-occurrence.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1989/02//
VL  - 51
IS  - 1
M3  - Article
SP  - 203
EP  - 212
SN  - 00222445
AB  - The present study focuses upon socioeconomic and marital outcomes associated with adolescent marriage, adolescent childbirth, and their co-occurrence in a group of 30- to 55-year-old white and black women. The poorest socioeconomic outcomes were associated with adolescent childbirth regardless of the presence or timing of first marriage. However, women who had adolescent marriages without co-occurring adolescent childbirth still experienced socioeconomic deficits relative to women who never married nor gave birth and women who first married and gave birth as adults. Marital instability was associated with both adolescent marriage and adolescent childbirth, although more positive marital outcomes were experienced by women who both married and gave birth in adolescence than by women who married in adolescence but never had children. Results suggest that the degree of risk associated with the co-occurrence of adolescent marriage and adolescent childbirth is different from that associated with either event alone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TEENAGE marriage
KW  - SOCIOECONOMICS
KW  - MARRIAGE
KW  - CHILDBIRTH
KW  - TEENAGERS
N1  - Accession Number: 5273978; Teti, Douglas M. 1 Lamb, Michael E. 2; Affiliation:  1: University of Maryland, Baltimore County  2: National Institute of Child Health and Human Development; Source Info: Feb89, Vol. 51 Issue 1, p203; Subject Term: TEENAGE marriage; Subject Term: SOCIOECONOMICS; Subject Term: MARRIAGE; Subject Term: CHILDBIRTH; Subject Term: TEENAGERS; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Oliveri, Mary Ellen
T1  - Family Assessment: Rationale, Methods, and Future Directions (Book).
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1989/02//
VL  - 51
IS  - 1
M3  - Book Review
SP  - 268
EP  - 269
SN  - 00222445
AB  - Reviews the book "Family Assessment: Rationale, Methods, and Future Directions," by Theodore Jacob and Daniel L. Tennenbaum.
KW  - FAMILY assessment
KW  - NONFICTION
KW  - JACOB, Theodore
KW  - TENNENBAUM, Daniel L.
KW  - FAMILY Assessment (Book)
N1  - Accession Number: 5274016; Oliveri, Mary Ellen 1; Affiliation:  1: National Institute of Mental Health; Source Info: Feb89, Vol. 51 Issue 1, p268; Subject Term: FAMILY assessment; Subject Term: NONFICTION; Reviews & Products: FAMILY Assessment (Book); People: JACOB, Theodore; People: TENNENBAUM, Daniel L.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104756633
T1  - Continuing care: a major issue in cancer pain management.
AU  - Ventafridda, V
Y1  - 1989/02//1989 Feb
N1  - Accession Number: 104756633. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Continuity of Patient Care
KW  - Neoplasms -- Physiopathology
KW  - Pain -- Therapy
KW  - Primary Health Care
KW  - Affective Symptoms -- Etiology
KW  - Neoplasms -- Complications
KW  - Social Adjustment
SP  - 137
EP  - 143
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 36
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Division of Pain Therapy and Palliative Care, National Cancer Institute, Milan, Italy.
U2  - PMID: 2919099.
DO  - 10.1016/0304-3959(89)90018-3
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-06495-053
AN  - 2006-06495-053
AU  - May, Conrad
AU  - Rapoport, Stanley I.
T1  - Treating Alzheimer's Disease.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1989/02//
VL  - 34
IS  - 2
SP  - 184
EP  - 185
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06495-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: May, Conrad; Laboratory of Neurosdences, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alzheimer's Disease; Drug Therapy; Psychotherapeutic Techniques; Treatment. Classification: Neurological Disorders & Brain Damage (3297); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Crook, Thomas (Ed); Bartus, Raymond T. (Ed); Ferris, Steven (Ed); Gershon, Samuel (Ed). Treatment Development Strategies for Alzheimer's Disease=Madison, CT: Powley, 1986. 699 pp; 1986. Page Count: 2. Issue Publication Date: Feb, 1989. 
AB  - Reviews the book, Treatment Development Strategies for Alzheimer's Disease edited by Thomas Crook, Raymond T. Bartus, Steven Ferris, and Samuel Gershon (see record [rid]1986-98479-000[/rid]). The devastation that is Alzheimer's disease is at once so immutable and frighteningly commonplace; understandably, this has led to the avid search for a cure, even though its root cause is unknown. The contributors to this book have sought to address this need by presenting the available clues and discussing the lines of reasoning on which possible therapies might be based. The chapters are written from diverse perspectives regarding a vast spectrum of topics (from the well-known cholinergic hypothesis to the brave new world of neural implants). Actually, two broad themes are intertwined throughout the book: first, the complex and often unique considerations that must be taken into account in developing drugs for Alzheimer's disease patients and, second, specific therapeutic approaches. This book is highly recommended for investigators of Alzheimer's disease, particularly those contemplating conducting clinical trials. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - treatment strategies
KW  - therapeutic approaches
KW  - drugs
KW  - Alzheimers disease
KW  - 1989
KW  - Alzheimer's Disease
KW  - Drug Therapy
KW  - Psychotherapeutic Techniques
KW  - Treatment
KW  - 1989
U2  - Crook, Thomas (Ed); Bartus, Raymond T. (Ed); Ferris, Steven (Ed); Gershon, Samuel (Ed). (1986); Treatment Development Strategies for Alzheimer's Disease; Madison, CT: Powley, 1986. 699 pp; 0-943378-05-2 (Paperback).
DO  - 10.1037/027683
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Long-term Vasodilator Therapy Effective in Chronic Aortic Insufficiency.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/03/
VL  - 261
IS  - 5
M3  - Article
SP  - 680
EP  - 680
SN  - 00987484
AB  - Reports that long-term vasodilator therapy is effective in chronic aortic insufficiency.  Benefit on left ventricular size and function; Comparison between receiving oral hydralazine and placebo; Effects of short-term treatment.
KW  - VASODILATORS
KW  - HYDRALAZINE
KW  - AORTIC valve insufficiency -- Treatment
N1  - Accession Number: 10949404; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p680; Subject Term: VASODILATORS; Subject Term: HYDRALAZINE; Subject Term: AORTIC valve insufficiency -- Treatment; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Abnormalities in Retinoblastoma Gene May Contribute to Other Malignancies.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/03/
VL  - 261
IS  - 5
M3  - Article
SP  - 680
EP  - 680
SN  - 00987484
AB  - Reports that abnormalities in retinoblastoma gene may contribute to other malignancies such as small cell lung cancer and breast cancer. Examination of the structure of the gene; Effects of its inactivation; Absence of retinoblastoma gene messenger RNA expression.
KW  - RETINOBLASTOMA
KW  - SMALL cell lung cancer
KW  - BREAST cancer
KW  - GENETIC aspects
N1  - Accession Number: 10949405; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p680; Subject Term: RETINOBLASTOMA; Subject Term: SMALL cell lung cancer; Subject Term: BREAST cancer; Subject Term: GENETIC aspects; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - New Research Findings in Arthritis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/03/
VL  - 261
IS  - 5
M3  - Article
SP  - 680
EP  - 680
SN  - 00987484
AB  - Reveals various research findings in arthritis.  Effects of sports activities during youth on osteoarthritis; Range of risk for swimming, football, baseball, basketball and running; Comparison between older and younger patients with respect to responses to slow-acting antirheumatic drugs.
KW  - ARTHRITIS
KW  - MEDICAL research
KW  - SPORTS
KW  - ANTIRHEUMATIC agents
N1  - Accession Number: 10949406; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p680; Subject Term: ARTHRITIS; Subject Term: MEDICAL research; Subject Term: SPORTS; Subject Term: ANTIRHEUMATIC agents; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Roper, Maryann
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/03/
VL  - 261
IS  - 5
M3  - Letter
SP  - 695
EP  - 696
SN  - 00987484
AB  - Presents a letter to the editor regarding the National Cancer Institute's clinical alert on node-negative breast cancer.
KW  - LETTERS to the editor
KW  - BREAST cancer
N1  - Accession Number: 10949413; Roper, Maryann 1; Affiliation:  1: National Cancer Institute; Source Info: 2/3/89, Vol. 261 Issue 5, p695; Subject Term: LETTERS to the editor; Subject Term: BREAST cancer; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schlom, Jeffrey
T1  - Innovations in Monoclonal Antibody Tumor Targeting.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/03/
VL  - 261
IS  - 5
M3  - Article
SP  - 744
EP  - 746
SN  - 00987484
AB  - Reveals the diagnostic and therapeutic implications of innovations in monoclonal antibody tumor targeting.  Case of a 33-year-old woman presented with a history of infertility; Ways to attack human carcinomas therapeutically; Use of iodine and dose fractionation.
KW  - MONOCLONAL antibodies -- Therapeutic use
KW  - CANCER -- Diagnosis
KW  - INFERTILITY
N1  - Accession Number: 10949443; Schlom, Jeffrey 1; Affiliation:  1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p744; Subject Term: MONOCLONAL antibodies -- Therapeutic use; Subject Term: CANCER -- Diagnosis; Subject Term: INFERTILITY; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mattson, Margaret E.
AU  - Boyd, Gayle
AU  - Byar, David
AU  - Brown, Charles
AU  - Callahan, James F.
AU  - Corle, Donald
AU  - Cullen, Joseph W.
AU  - Greenblatt, Janet
AU  - Haley, Nancy J.
AU  - Hammond, S. Katharine
AU  - Lewtas, Joellen
AU  - Reeves, Warren
T1  - Passive Smoking on Commercial Airline Flights.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/10/
VL  - 261
IS  - 6
M3  - Article
SP  - 867
EP  - 872
SN  - 00987484
AB  - Studies the effects of passive smoking on the health of commercial airline passengers.  Assessment of in-flight exposure to nicotine, urinary cotinine levels and symptom self reports; Relationship of tobacco smoke levels with cotinine amounts in urine of passengers and attendants; Link between nicotine exposure and changes in eye and nose symptoms; Effect of nicotine exposure on passenger annoyance and smoke levels.
KW  - SMOKING
KW  - AIR travel
KW  - NICOTINE
KW  - URINALYSIS
KW  - CIGARETTE smoke
N1  - Accession Number: 10949671; Mattson, Margaret E. 1 Boyd, Gayle 1 Byar, David 1 Brown, Charles 1 Callahan, James F. 1 Corle, Donald 1 Cullen, Joseph W. 1 Greenblatt, Janet 2 Haley, Nancy J. 3 Hammond, S. Katharine 4 Lewtas, Joellen 5 Reeves, Warren 6; Affiliation:  1: National Cancer Institute, Md  2: Prospect Associates, Md  3: American Health Foundation, NY  4: University of Massachusetts Medical School, Worcester  5: Environmental Protection Agency, NC  6: Air Canada, Montreal; Source Info: 2/10/89, Vol. 261 Issue 6, p867; Subject Term: SMOKING; Subject Term: AIR travel; Subject Term: NICOTINE; Subject Term: URINALYSIS; Subject Term: CIGARETTE smoke; NAICS/Industry Codes: 481211 Nonscheduled Chartered Passenger Air Transportation; NAICS/Industry Codes: 481111 Scheduled Passenger Air Transportation; NAICS/Industry Codes: 481110 Scheduled air transportation; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wingfield, Paul
AU  - Graber, Pierre
AU  - Shaw, Alan R.
AU  - Gronenborn, Angela M.
AU  - Clore, G. Marius
AU  - MacDonald, H. Robson
T1  - Preparation, characterization and application of interleukin-1β mutant proteins with surface-accessible cysteine residues.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/02/15/
VL  - 179
IS  - 3
M3  - Article
SP  - 565
EP  - 571
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Two mutants of interleukin-1β (K27C and K138C) were produced using site-specific mutagenesis in which lysine residues at positions 27 and 138 of the mature protein sequence were substituted by cysteine residues. The conformations of the mutant proteins were studied by ¹H-NMR spectroscopy and shown to be similar to the wild-type protein. The receptor-binding affinity and biological activity of K27C and K138C were also similar to wild-type protein. The substituted cysteines in both mutant proteins were shown to be solvent-accessible as judged by their reactivity towards sulfhydryl reagents. As the wild-type protein contains two cysteines, which are both solvent-inaccessible in the native state, the mutants offer the opportunity to introduce probes in a sequence-specific manner via reaction with sulfhydryl groups. Examples of this are described in which the K138C was disulfide-linked to phycobiliproteins. The highly fluorescent conjugates had similar receptor-binding affinities to that of the wild-type unconjugated protein and were found suitable for flow-cytometric analysis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKINS
KW  - PROTEINS
KW  - MUTAGENESIS
KW  - FLOW cytometry
KW  - NUCLEAR magnetic resonance spectroscopy
KW  - AMINO acid sequence
N1  - Accession Number: 13725234; Wingfield, Paul 1 Graber, Pierre 1 Shaw, Alan R. 1 Gronenborn, Angela M. 2 Clore, G. Marius 2 MacDonald, H. Robson 3; Affiliation:  1: Glaxo Institute for Molecular Biology S.A., Geneva  2: Laboratory of Chemical Physics. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda  3: Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges; Source Info: 2/15/89, Vol. 179 Issue 3, p565; Subject Term: INTERLEUKINS; Subject Term: PROTEINS; Subject Term: MUTAGENESIS; Subject Term: FLOW cytometry; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: AMINO acid sequence; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 106711058
T1  - Behavioral, social and mental health aspects of home care for older Americans.
AU  - Harper MS
Y1  - 1989/02/22/
N1  - Accession Number: 106711058. Language: English. Entry Date: 20040312. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128. 
KW  - Home Health Care -- Trends -- In Old Age
KW  - Mental Disorders -- In Old Age
KW  - Social Behavior Disorders -- In Old Age
KW  - Accidental Falls -- Epidemiology
KW  - Aged
KW  - Aged, 80 and Over
KW  - Delirium -- Epidemiology
KW  - Dementia -- Epidemiology
KW  - Dementia -- Etiology
KW  - Depression -- Epidemiology
KW  - Drug Interactions
KW  - Drugs -- Adverse Effects
KW  - Elder Abuse -- Epidemiology
KW  - Female
KW  - Geriatric Assessment
KW  - Male
KW  - Suicide -- Epidemiology
KW  - Suicide -- Risk Factors
KW  - Wandering Behavior
SP  - 61
EP  - 124
JO  - Home Health Care Services Quarterly
JF  - Home Health Care Services Quarterly
JA  - HOME HEALTH CARE SERV Q
VL  - 9
IS  - 4
PB  - Taylor & Francis Ltd
AB  - Ninety-five percent (95 percent) of the elderly live in the community. At least five million of them need help with activities of daily living. Eighty percent have one or more chronic illness. Eighteen to 25 percent of the elderly have significant mental symptomatology. Only four percent of the elderly visit the community mental health centers (Ernst 1977; Talbott 1985). The primary providers of mental health services to the elderly are the general practitioners, the primary health care nurse, the home health aide psychiatric social workers, members of the family, and a few clinical geropsychologists (German 1987). Over half of the home health care clients are elderly. The primary home health care providers are 'challenged' in providing comprehensive health services to the elderly in their homes--often because of a lack of training of the primary home health care provider or because of lack of access because of agencies' policies regarding the acceptance of patients with behavioral, social and mental disorders, including Alzheimer's disease. In this paper, I have profiled the behavioral, social and mental health needs of the elderly with physical illnesses as well as those with behavioral, social and mental disorders. I have dealt with those specific conditions which home health care providers and families find specifically challenging and worrisome, namely: Delirium (confusional states) Suicidal ideation and attempts Psychological assessment Dementia of Alzheimer's type Depression Delirium: (confusion and other behavioral problems associated with hip fractures) Psychotropic drug interaction Wandering Every effort must be made to respect the privacy of the elderly, protect the elderly from research risk, get informed consent when indicated, provide counseling and always assure a high quality of care and supervision. There must be a current plan of care in which both the patient and family participate when feasible. Every effort and plan of care must focus on the maintenance of independence and self-care capabilities and prevention of excessive disabilities.
SN  - 0162-1424
AD  - Coordinator, Long Term Care Programs, Mental Disorder of Aging Research Branch, National Institute of Mental Health, U.S. Department of Health & Human Services, Rockville, MD
U2  - PMID: 10303290.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Quinn, Thomas C.
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/24/
VL  - 261
IS  - 8
M3  - Letter
SP  - 1148
EP  - 1149
SN  - 00987484
AB  - Responds to a letter to the editor of the 'Journal of the American Medical Association,' about the specificity and sensitivity of the rapid latex agglutination assay used in diagnosing HIV infections.
KW  - AGGLUTINATION tests
KW  - HIV infections -- Diagnosis
KW  - MEDICAL screening
KW  - DIAGNOSIS
KW  - LETTERS to the editor
N1  - Accession Number: 10867237; Quinn, Thomas C. 1; Affiliation:  1: National Institute of Allergy and Infectious Diseases, Md; Source Info: 2/24/89, Vol. 261 Issue 8, p1148; Subject Term: AGGLUTINATION tests; Subject Term: HIV infections -- Diagnosis; Subject Term: MEDICAL screening; Subject Term: DIAGNOSIS; Subject Term: LETTERS to the editor; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Merril, Carl R.
AU  - Harrington, Michael G.
AU  - Sunderland, Trey
AU  - Merril, C R
AU  - Harrington, M G
AU  - Sunderland, T
T1  - Plasma dehydroepiandrosterone levels in HIV infection.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/24/
VL  - 261
IS  - 8
M3  - letter
SP  - 1149
EP  - 1149
SN  - 00987484
AB  - Presents a letter to the editor of the 'Journal of the American Medical Association,' about the possible influence on dehydroepiandrosterone of infections with HIV.
KW  - DEHYDROEPIANDROSTERONE
KW  - HIV infections
KW  - COMMUNICABLE diseases
KW  - LETTERS to the editor
KW  - AGE distribution (Demography)
KW  - ANIMALS
KW  - HIV seroconversion
N1  - Accession Number: 10867238; Merril, Carl R. 1 Harrington, Michael G. 1 Sunderland, Trey 1 Merril, C R Harrington, M G Sunderland, T; Affiliation:  1: National Institute of Mental Health, Md; Source Info: 2/24/89, Vol. 261 Issue 8, p1149; Subject Term: DEHYDROEPIANDROSTERONE; Subject Term: HIV infections; Subject Term: COMMUNICABLE diseases; Subject Term: LETTERS to the editor; Subject Term: AGE distribution (Demography); Subject Term: ANIMALS; Subject Term: HIV seroconversion; Number of Pages: 1p; Document Type: letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Wittes, Robert E.
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/24/
VL  - 261
IS  - 8
M3  - Letter
SP  - 1151
EP  - 1151
SN  - 00987484
AB  - Presents a letter to the editor of the 'Journal of the American Medical Association,' about the financial aspects of clinical trials.
KW  - CLINICAL trials
KW  - MEDICAL experimentation on humans
KW  - MEDICAL economics
KW  - LETTERS to the editor
KW  - ECONOMIC aspects
N1  - Accession Number: 10867245; Wittes, Robert E. 1; Affiliation:  1: National Cancer Institute, Md; Source Info: 2/24/89, Vol. 261 Issue 8, p1151; Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; Subject Term: MEDICAL economics; Subject Term: LETTERS to the editor; Subject Term: ECONOMIC aspects; Number of Pages: 1/5p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shimokata, Hiroshi
AU  - Muller, Denis C.
AU  - Andres, Reubin
T1  - Studies in the Distribution of Body Fat.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/02/24/
VL  - 261
IS  - 8
M3  - Article
SP  - 1169
EP  - 1173
SN  - 00987484
AB  - Examines cross-sectional associations between smoking habits, body mass index and waist-hip ratio (WHR) in men.  Finding that weight and body mass index were significantly lower in cigarette smokers; Increase in the WHR of those who started smoking despite their loss of weight; Harmful effects of cigarette smoking on the pattern of distribution of body fat.
KW  - FAT
KW  - TOBACCO -- Physiological effect
KW  - CIGARETTE smokers
KW  - MEN -- Physiology
N1  - Accession Number: 10867257; Shimokata, Hiroshi 1 Muller, Denis C. 1 Andres, Reubin 1; Affiliation:  1: Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institute of Health, Baltimore; Source Info: 2/24/89, Vol. 261 Issue 8, p1169; Subject Term: FAT; Subject Term: TOBACCO -- Physiological effect; Subject Term: CIGARETTE smokers; Subject Term: MEN -- Physiology; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Furue, Masutaka
AU  - Katz, Stephen I.
T1  - Direct Effects of Glucocorticosteroids on Epidermal Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/03//
VL  - 92
IS  - 3
M3  - Article
SP  - 342
EP  - 347
SN  - 0022202X
AB  - To determine the direct effects of glucocorticosteroids on epidermal Langerhans cells (LC), we treated isolated LC with dexarnethasone (DEX) in vitro, and investigated Ia expression by LC using immunofluorescence microscopy and FACS analysis. We found that DEX directly decreased the number of Ia+ LC in a dose-and time-dependent manner. Pulse incubation with DEX also inhibited the immunostimulatory function of LC in vitro. FACS analysis demonstrated that LC detected in DEX-treated culture expressed a similar amount of Ia antigen and Fc receptor on the cell surface as LC cultured with the solvent control, suggesting that LC may be composed of a heterogeneous population in terms of sensitivity to DEX, and DEX may completely abolish the expression of surface molecules on a subpopulation of LC or may be cytolytic to this sensitive population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADRENOCORTICAL hormones
KW  - LANGERHANS cells
KW  - MICROSCOPY
KW  - ANTIGENS
KW  - CELL membranes
KW  - IMMUNOFLUORESCENCE
N1  - Accession Number: 12277165; Furue, Masutaka 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1989, Vol. 92 Issue 3, p342; Subject Term: ADRENOCORTICAL hormones; Subject Term: LANGERHANS cells; Subject Term: MICROSCOPY; Subject Term: ANTIGENS; Subject Term: CELL membranes; Subject Term: IMMUNOFLUORESCENCE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277165
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Reinterpreting the Myers-Briggs Type Indicator From the Perspective of the Five-Factor Model of Personality.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1989/03//
VL  - 57
IS  - 1
M3  - Article
SP  - 17
EP  - 40
PB  - Wiley-Blackwell
SN  - 00223506
AB  - The Myers-Briggs Type Indicator (MBTI, Myers & McCaulley, 1985) was evaluated from the perspectives of Jung's theory of psychological types and the five-factor model of personality as measured by self-reports and peer ratings on the NEO Personality Inventory (NEO-PI, Costa & McCrae, 1985b) Data were provided by 267 men and 201 women ages 19 to 93 Consistent with earlier research and evaluations, there was no support for the view that the MBTI measures truly dichotomous preferences or qualitatively distinct types, instead, the instrument measures four relatively independent dimensions The interpretation of the Judging--Perceiving index was also called into question The data suggest that Jung's theory is either incorrect or inadequately operationalized by the MBTI and cannot provide a sound basis for interpreting it However, correlational analyses showed that the four MBTI indices did measure aspects of four of the five major dimensions of normal personality The five-factor model provides an alternative basis for interpreting MBTI findings within a broader, more commonly shared conceptual framework [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MYERS-Briggs Type Indicator
KW  - PSYCHOLOGY
KW  - PEER review (Professional performance)
KW  - PERSONALITY tests
KW  - SELF-evaluation
KW  - CORRELATION (Statistics)
N1  - Accession Number: 8972588; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Mar89, Vol. 57 Issue 1, p17; Subject Term: MYERS-Briggs Type Indicator; Subject Term: PSYCHOLOGY; Subject Term: PEER review (Professional performance); Subject Term: PERSONALITY tests; Subject Term: SELF-evaluation; Subject Term: CORRELATION (Statistics); Number of Pages: 24p; Document Type: Article
L3  - 10.1111/1467-6494.ep8972588
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Follmann, Dean A.
AU  - Lambert, Diane
T1  - Generalizing Logistic Regression by Nonparametric Mixing.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1989/03//
VL  - 84
IS  - 405
M3  - Article
SP  - 295
SN  - 01621459
AB  - Logistic regression is a common technique for analyzing the effect of a covariate vector x on the number of successes y in m trials when y has a binomial distribution. But at times either the logistic curve does not describe the probability of success p(x) adequately, or m is larger than 1 and y is more variable than the binomial distribution allows. Overdispersion relative to the binomial distribution is possible if the m trials in a set or "litter" are positively correlated, an important covariate is omitted, or x is measured with error. A simple way to accommodate departures from the logit link and overdispersion is to introduce a random intercept alpha and thus permit a random propensity toward success. When alpha varies between individual binary trials according to a discrete or multimodal distribution, p(x) has smooth steps and y has a binomial(m, p(x)) distribution. When the random a is constant for a set of m binary trials and varies between sets of m trials according to a discrete or multimodal distribution, p(x) has smooth steps and y is overdispersed relative to the binomial distribution. In this article the distribution of a is left unspecified and estimated by nonparametric maximum likelihood. The estimated distribution of a is discrete, so the distribution of y and all of its properties are easily estimated for any x. Two examples are considered. In the first, the logit link is inadequate, but y appears to be binomial. Hence a is allowed to vary between binary trials. In the second, y's (with m > 1) from the same design point are more dispersed than the binomial distribution would predict, and there are outliers. Allowing alpha to vary randomly between sets of m trials accounts for the overdispersion and seems to temper the... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANALYSIS of covariance
KW  - REGRESSION analysis
KW  - DISTRIBUTION (Probability theory)
KW  - PROBABILITY theory
KW  - LOGISTIC regression analysis
KW  - BINOMIAL distribution
KW  - VARIABLES (Mathematics)
KW  - BINOMIAL theorem
KW  - Extrabinomial variability
KW  - Link
KW  - Logit mixture
KW  - Overdispersion.
N1  - Accession Number: 4608698; Follmann, Dean A. 1; Lambert, Diane 2; Affiliations: 1: Mathematical Statistician, Biostatistics Re- search Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892.; 2: Member of Technical Staff, AT&T Bell Laboratories, Murray Hill NJ 07974.; Issue Info: Mar1989, Vol. 84 Issue 405, p295; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: REGRESSION analysis; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: PROBABILITY theory; Subject Term: LOGISTIC regression analysis; Subject Term: BINOMIAL distribution; Subject Term: VARIABLES (Mathematics); Subject Term: BINOMIAL theorem; Author-Supplied Keyword: Extrabinomial variability; Author-Supplied Keyword: Link; Author-Supplied Keyword: Logit mixture; Author-Supplied Keyword: Overdispersion.; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 104755237
T1  - Raising the profile of epidemiological research: discussion paper.
AU  - Roth, C A
AU  - Lenfant, C
Y1  - 1989/03//
N1  - Accession Number: 104755237. Language: English. Entry Date: 20110610. Revision Date: 20170223. Publication Type: journal article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7802879. 
KW  - Epidemiology
KW  - Research
KW  - National Institutes of Health (U.S.)
KW  - Peer Review
KW  - Research Support
KW  - United States
SP  - 147
EP  - 150
JO  - Journal of the Royal Society of Medicine
JF  - Journal of the Royal Society of Medicine
JA  - J R SOC MED
VL  - 82
IS  - 3
PB  - Sage Publications, Ltd.
SN  - 0141-0768
AD  - National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892.
U2  - PMID: 2704013.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104755323
T1  - Phenytoin in reflex sympathetic dystrophy.
AU  - Chaturvedi, S K
Y1  - 1989/03//1989 Mar
N1  - Accession Number: 104755323. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Phenytoin -- Therapeutic Use
KW  - Reflex Sympathetic Dystrophy -- Drug Therapy
KW  - Adult
KW  - Male
KW  - Pain -- Etiology
KW  - Reflex Sympathetic Dystrophy -- Complications
SP  - 379
EP  - 380
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 36
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
U2  - PMID: 2710566.
DO  - 10.1016/0304-3959(89)90099-7
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wyatt, Richard G.
T1  - Inactivating the Pertussis Toxin.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/03/03/
VL  - 261
IS  - 9
M3  - Article
SP  - 1260
EP  - 1260
SN  - 00987484
AB  - Reports on findings of a study of the enzymatic activity of the S1 subunit of the pertussis toxin molecule, conducted by scientists at the National Institute of Allergy and Infectious Diseases' Rocky Mountain Laboratories in Hamilton, Montana, in collaboration with researchers from Amgen Inc. and Japanese National Institute of Health.  Site-specific mutation; Effects of deleting a part of the genetic region coding for the S1.
KW  - PERTUSSIS toxin
KW  - GENETIC code
KW  - NATIONAL Institute of Allergy & Infectious Diseases (U.S.)
KW  - AMGEN Inc.
N1  - Accession Number: 10975853; Wyatt, Richard G. 1; Affiliation:  1: National Institutes of Health; Source Info: 3/3/89, Vol. 261 Issue 9, p1260; Subject Term: PERTUSSIS toxin; Subject Term: GENETIC code; Company/Entity: NATIONAL Institute of Allergy & Infectious Diseases (U.S.) DUNS Number:  Ticker:  Company/Entity: AMGEN Inc. DUNS Number: 039976196 Ticker: AMGN; Number of Pages: 1/8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hughes, John R.
AU  - Gust, Steven W.
AU  - Keenan, Robert M.
AU  - Fenwick, James W.
AU  - Healey, Margaret L.
T1  - Nicotine vs Placebo Gum in General Medical Practice.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/03/03/
VL  - 261
IS  - 9
M3  - Article
SP  - 1300
EP  - 1305
SN  - 00987484
AB  - Reports on findings of a study of pharmacologic effects of nicotine gum to increase smoking cessation.  Study design; Point prevalence abstinence rates; Internal validity checks; Predictors of outcome; Prevalence of side effects with nicotine than placebo gum.
KW  - SMOKING cessation products
KW  - SMOKING cessation
KW  - TOBACCO use -- Prevention
KW  - HEALTH products
N1  - Accession Number: 10975882; Hughes, John R. 1 Gust, Steven W. 2 Keenan, Robert M. 3 Fenwick, James W. 4 Healey, Margaret L. 5; Affiliation:  1: Departments of Psychiatry, Psychology, and Family Practice, University of Vermont, Burlington  2: National Institute on Drug Abuse, Washington, DC  3: Department of Psychiatry, University of Minnesota  4: Department of Mathematics and Statistics, University of Vermont, Burlington  5: Park-Nicollet Medical Foundation, Minneapolis; Source Info: 3/3/89, Vol. 261 Issue 9, p1300; Subject Term: SMOKING cessation products; Subject Term: SMOKING cessation; Subject Term: TOBACCO use -- Prevention; Subject Term: HEALTH products; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621990 All other ambulatory health care services; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Siraganian, Patricia A.
AU  - Mulvihill, John J.
AU  - Mulivor, Richard A.
AU  - Miller, Robert W.
T1  - Benign Familial Hyperphosphatasemia.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/03/03/
VL  - 261
IS  - 9
M3  - Article
SP  - 1310
EP  - 1312
SN  - 00987484
AB  - Studies a family with benign hyperphosphatasemia to determine the genetics and enzyme defect.  Student subjects and methods; Genes code for serum alkaline phosphatase (ALP) activity suggesting bone or liver disease; Physiological substrates; Effects of benign elevations of serum ALP activity; Mode of inheritance for benign hyperphosphatasemia in the family.
KW  - ALKALINE phosphatase
KW  - FAMILIAL diseases
KW  - BONES -- Diseases
KW  - LIVER diseases
KW  - GENETIC aspects
N1  - Accession Number: 10975884; Siraganian, Patricia A. 1 Mulvihill, John J. 1 Mulivor, Richard A. 2 Miller, Robert W. 1; Affiliation:  1: Clinical Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md  2: Conell Institute for Medical Research, Camden, NJ; Source Info: 3/3/89, Vol. 261 Issue 9, p1310; Subject Term: ALKALINE phosphatase; Subject Term: FAMILIAL diseases; Subject Term: BONES -- Diseases; Subject Term: LIVER diseases; Subject Term: GENETIC aspects; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoofnagle, Jay H.
T1  - Type D (Delta) Hepatitis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/03/03/
VL  - 261
IS  - 9
M3  - Article
SP  - 1321
EP  - 1325
SN  - 00987484
AB  - Reports on the case of a 40-year-old man with type D hepatitis.  Medical history of the patient; Background on hepatitis delta virus (HDV); Clinical course of HDV; Difficulty in the diagnosis of HDV; Epidemiology of delta hepatitis; Association between delta hepatitis and type B hepatitis.
KW  - HEPATITIS D
KW  - DELTA-associated agent
KW  - HEPATITIS B
KW  - HEPATITIS
N1  - Accession Number: 10975886; Hoofnagle, Jay H. 1; Affiliation:  1: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md; Source Info: 3/3/89, Vol. 261 Issue 9, p1321; Subject Term: HEPATITIS D; Subject Term: DELTA-associated agent; Subject Term: HEPATITIS B; Subject Term: HEPATITIS; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Landesman, Sheldon H.
AU  - Minkoff, Howard L.
AU  - Willoughby, Anne
T1  - HIV Disease in Reproductive Age Women: A Problem of the Present.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/03/03/
VL  - 261
IS  - 9
M3  - Editorial
SP  - 1326
EP  - 1327
SN  - 00987484
AB  - Editorial.  Discusses the human immunodeficiency virus (HIV) disease in reproductive age women.  Ratio of births to an HIV-infected women in New York City; Selwyn and colleagues' prospective evaluation of pregnancies among drug-using seropositive and seronegative women; Consequences of HIV infection in pregnant women.
KW  - HIV (Viruses)
KW  - HIV infections
KW  - HIV-positive women
KW  - PREGNANCY complications
N1  - Accession Number: 10975887; Landesman, Sheldon H. 1 Minkoff, Howard L. 1 Willoughby, Anne 2; Affiliation:  1: State University of New York, Health Science Center, Brooklyn, NY  2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Source Info: 3/3/89, Vol. 261 Issue 9, p1326; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: HIV-positive women; Subject Term: PREGNANCY complications; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wolkowitz, Owen M.
AU  - Rapaport, Mark
AU  - Wolkowitz, O M
T1  - Long-lasting behavioral changes following prednisone withdrawal.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/03/24/
VL  - 261
IS  - 12
M3  - case study
SP  - 1731
EP  - 1732
SN  - 00987484
AB  - Examines cases of long-lasting behavioral changes following prednisone withdrawal.  Clinical manifestations; Diagnostic findings; Treatment.
KW  - PREDNISONE
KW  - PSYCHOPHARMACOLOGY
N1  - Accession Number: 10867313; Wolkowitz, Owen M. 1 Rapaport, Mark 2 Wolkowitz, O M; Affiliation:  1: Langley Porter Psychiatric Institute, University of California  2: National Institute of Mental Health; Source Info: 3/24/89-3/31/89, Vol. 261 Issue 12, p1731; Subject Term: PREDNISONE; Subject Term: PSYCHOPHARMACOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: case study
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Huff, J. E.
T1  - UNDERSTANDING CANCER.
JO  - BioScience
JF  - BioScience
Y1  - 1989/04//
VL  - 39
IS  - 4
M3  - Book Review
SP  - 266
EP  - 267
SN  - 00063568
AB  - Reviews the book 'Dimensions of Cancer,' by C. E. Kupchella.
KW  - Cancer
KW  - Nonfiction
KW  - Kupchella, C. E.
KW  - Dimensions of Cancer (Book)
N1  - Accession Number: 10100627; Huff, J. E. 1; Affiliations: 1: National Institutes of Health, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709; Issue Info: Apr89, Vol. 39 Issue 4, p266; Subject Term: Cancer; Subject Term: Nonfiction; Reviews & Products: Dimensions of Cancer (Book); People: Kupchella, C. E.; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 569
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kostiuk, Peter F.
AU  - Follmann, Dean A.
T1  - Learning Curves, Personal Characteristics, and Job Performance.
JO  - Journal of Labor Economics
JF  - Journal of Labor Economics
Y1  - 1989/04//
VL  - 7
IS  - 2
M3  - Article
SP  - 129
PB  - University of Chicago Press
SN  - 0734306X
AB  - Data on Naval Reserve recruiters are used to estimate the effects of on-the-job learning, experience, and individual characteristics on job performance. Generalizations of the Poisson distribution form the basis for estimating the effects of explanatory variables and control for individual heterogeneity and overdispersion. The findings show strong learning effects during the first 2 years on the job. Furthermore, lower pay-grade individuals have steeper learning curves than individuals in higher pay grades. Estimates of individual differences in productivity show a large variance in unobserved ability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Labor Economics is the property of University of Chicago Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EMPLOYEE training
KW  - JOB performance
KW  - DISTRIBUTION (Probability theory)
KW  - VARIANCES
KW  - WAGES
KW  - ESTIMATION theory
KW  - NAVAL reserves
KW  - POISSON distribution
KW  - PERFORMANCE
KW  - RECRUITING & enlistment (Armed Forces)
N1  - Accession Number: 4661354; Kostiuk, Peter F. 1; Follmann, Dean A. 2; Affiliations: 1: Center for Naval Analyses.; 2: National Heart, Lung, and Blood Institute.; Issue Info: Apr89, Vol. 7 Issue 2, p129; Thesaurus Term: EMPLOYEE training; Thesaurus Term: JOB performance; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: VARIANCES; Thesaurus Term: WAGES; Thesaurus Term: ESTIMATION theory; Subject Term: NAVAL reserves; Subject Term: POISSON distribution; Subject Term: PERFORMANCE; Subject Term: RECRUITING & enlistment (Armed Forces); NAICS/Industry Codes: 611430 Professional and Management Development Training; Number of Pages: 18p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 104755418
T1  - Transdermal fentanyl for pain control in patients with cancer.
AU  - Miser, A W
AU  - Narang, P K
AU  - Dothage, J A
AU  - Young, R C
AU  - Sindelar, W
AU  - Miser, J S
Y1  - 1989/04//1989 Apr
N1  - Accession Number: 104755418. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Fentanyl -- Therapeutic Use
KW  - Neoplasms -- Complications
KW  - Pain -- Drug Therapy
KW  - Administration, Transcutaneous
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Chronic Disease
KW  - Female
KW  - Fentanyl -- Administration and Dosage
KW  - Male
KW  - Middle Age
KW  - Pain -- Etiology
SP  - 15
EP  - 21
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 37
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pediatric Branch, National Cancer Institute, Bethesda, MD 20892.
U2  - PMID: 2726274.
DO  - 10.1016/0304-3959(89)90148-6
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bickers, David R.
AU  - Lowy, Douglas R.
T1  - Carcinogenesis: A Fifty-Year Historical Perspective.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/04/15/
VL  - 92
M3  - Article
SP  - 121S
EP  - 131S
SN  - 0022202X
AB  - In recent years, the focus of carcinogenesis studies has shifted to mechanistic analyses and to the contribution of specific genes to tumorigenesis. These analyses have suggested that cutaneous carcinogenesis at the molecular level results after several identifiable genetic attentions have occurred in the cell. Thus model systems of cutaneous carcinogenesis, in which early studies provided strong evidence for cancer being a multistep process, are now identifying the specific genes whose alterations contribute to malignant conversion. This historically oriented review highlights these and related advances in understanding cutaneous carcinogenesis and suggests some questions that may be addressed in future studies.
KW  - CARCINOGENESIS
KW  - CANCER -- Study & teaching
KW  - GENETIC disorders
KW  - MOLECULAR biology
KW  - BIOCHEMISTRY
KW  - SKIN diseases
N1  - Accession Number: 13075095; Bickers, David R. 1 Lowy, Douglas R. 2; Affiliation:  1: Department of Dermatology, Case Western Reserve University, School of Medicine, Cleveland, Ohio.  2: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr89Supplement, Vol. 92, p121S; Subject Term: CARCINOGENESIS; Subject Term: CANCER -- Study & teaching; Subject Term: GENETIC disorders; Subject Term: MOLECULAR biology; Subject Term: BIOCHEMISTRY; Subject Term: SKIN diseases; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1523-1747.ep13075095
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Miller, Laurence H.
AU  - Katz, Stephen I.
AU  - Moshell, Alan N.
T1  - NIH Centennial: The Influence of NIH on Dermatology Research Training.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/04/15/
VL  - 92
M3  - Article
SP  - 177S
EP  - 178S
SN  - 0022202X
AB  - Dermatologists can improve the care of their patients only when there is progress in the fundamental and clinical sciences. The training grant and research grant programs of the U.S. National Institutes of Health (NIH) have played a most important role in the evolution of dermatology in the United States since World War II. NIH funds have been of incalculable benefit. Early progress in our specialty was shaped largely by a small number of individuals located in four or five privileged centers, where there was sufficient local financial support to provide full-time physicians, space, equipment, and supplies. In only two or three of these schools money was derived from private endowments which provided a great advantage in early development. Thirty-five years ago the majority of medical schools essentially had no programs in dermatology, a situation which is much improved today, but even now has not been satisfactorily resolved.
KW  - DERMATOLOGISTS
KW  - PUBLIC health -- United States
KW  - SKIN diseases
KW  - FEDERAL aid to medical care research
KW  - FUNDRAISING
KW  - UNITED States
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 13075543; Miller, Laurence H. 1 Katz, Stephen I. 2 Moshell, Alan N. 1; Affiliation:  1: Skin Diseases Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Apr89Supplement, Vol. 92, p177S; Subject Term: DERMATOLOGISTS; Subject Term: PUBLIC health -- United States; Subject Term: SKIN diseases; Subject Term: FEDERAL aid to medical care research; Subject Term: FUNDRAISING; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 813210 Grant-making and giving services; NAICS/Industry Codes: 813211 Grantmaking Foundations; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep13075543
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Linet, Martha S.
AU  - Stewart, Walter F.
AU  - Celentano, David D.
AU  - Ziegler, Dewey
AU  - Sprecher, Martha
T1  - An Epidemiologic Study of Headache Among Adolescents and Young Adults.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/04/21/
VL  - 261
IS  - 15
M3  - Article
SP  - 2211
SN  - 00987484
AB  - Presents a population-based telephone interview study on headache among adolescents and young adults in Washington County, Maryland.  Number of headaches reported in a span of four weeks; Selection of study subjects; Data culling and analysis; Characteristics of headaches.
KW  - HEADACHE
KW  - INTERVIEWING
KW  - PAIN
KW  - WASHINGTON County (Md.)
KW  - MARYLAND
KW  - UNITED States
N1  - Accession Number: 10868288; Linet, Martha S. 1,2 Stewart, Walter F. 1 Celentano, David D. 1 Ziegler, Dewey 3 Sprecher, Martha 1; Affiliation:  1: Department of Epidemiology, Division of Behavioral Sciences and Health Education and Health Education, Department of Health Policy and Management, The Hopkins University School of Hygiene and Public Health  2: Analytic Studies Section, Biostatic Branch, Epidemiology and Biostatics Program, Division of Cancer Etiology, National Cancer Institute  3: Department of Neurology, University of Kansas; Source Info: 4/21/89, Vol. 261 Issue 15, p2211; Subject Term: HEADACHE; Subject Term: INTERVIEWING; Subject Term: PAIN; Subject Term: WASHINGTON County (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bhathena, Sam J.
AU  - Berlin, Elliott
AU  - Judd, Joseph
AU  - Nair, Padmanabhan P.
AU  - Kennedy, Bruce W.
AU  - Jones, Jacquelyn
AU  - Smith, Patricia M.
AU  - Jones, Yvonne
AU  - Taylor, Philip R.
AU  - Campbell, William S.
T1  - Hormones regulating lipid and carbohydrate metabolism in premenopausal women: modulation by dietary lipids.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989/05//
VL  - 49
IS  - 5
M3  - Article
SP  - 752
EP  - 757
SN  - 00029165
AB  - The effect of high- and low-fat diets with different levels of fatty acid unsaturation on plasma hormones involved in lipid metabolism was studied during different phases of the menstrual cycle in 31 premenopausal women. Subjects were divided into two groups and were fed controlled diets containing 39% fat with a ratio of polyunsaturated to saturated fatty acids (P:S) of either 0.3 or 1.0 for four menstrual cycles and then switched to a 19% fat diet with the same P:S for another four cycles. Blood samples were analyzed during both the follicular and luteal phases. A significant direct effect of level of dietary fat was observed on plasma cortisol and dehydroepiandrosterone-sulphate whereas an inverse relationship was seen for plasma insulin. Both plasma insulin and growth hormone levels were higher during the luteal compared with the follicular phase of the menstrual cycle. None of the hormones was affected by the level of unsaturation of dietary fats. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Lipid metabolism
KW  - Carbohydrate metabolism
KW  - Insulin
KW  - Low-fat diet
KW  - High-fat diet
KW  - Saturated fatty acids
KW  - Unsaturated fatty acids
KW  - cortisol
KW  - DHEA-S
KW  - glucagon
KW  - growth hormone
KW  - high-fat diet
KW  - low-fat diet
KW  - menstrual cycle
KW  - P: S
N1  - Accession Number: 91731627; Bhathena, Sam J. 1,2; Berlin, Elliott 1,2; Judd, Joseph 1,2; Nair, Padmanabhan P. 1,2; Kennedy, Bruce W. 1,2; Jones, Jacquelyn 1,2; Smith, Patricia M. 1,2; Jones, Yvonne 1,2; Taylor, Philip R. 1,2; Campbell, William S. 1,2; Affiliations: 1: Carbohydrate Nutrition Laboratory and the Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD; 2: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; Issue Info: May1989, Vol. 49 Issue 5, p752; Subject Term: Lipid metabolism; Subject Term: Carbohydrate metabolism; Subject Term: Insulin; Subject Term: Low-fat diet; Subject Term: High-fat diet; Subject Term: Saturated fatty acids; Subject Term: Unsaturated fatty acids; Author-Supplied Keyword: cortisol; Author-Supplied Keyword: DHEA-S; Author-Supplied Keyword: glucagon; Author-Supplied Keyword: growth hormone; Author-Supplied Keyword: high-fat diet; Author-Supplied Keyword: low-fat diet; Author-Supplied Keyword: menstrual cycle; Author-Supplied Keyword: P: S; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Amatayakul, Kosin
AU  - Underwood, Barbara A.
AU  - Ruckphaopunt, Somsri
AU  - Singkamani, Ratree
AU  - Linpisarn, Sukanya
AU  - Leelapat, Posri
AU  - Thanangkul, Ousa
T1  - Oral contraceptives: effect of long-term use on liver vitamin A storage assessed by the relative dose response test.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989/05//
VL  - 49
IS  - 5
M3  - Article
SP  - 845
EP  - 848
SN  - 00029165
AB  - Vitamin A status measured by the relative dose response (RDR) test was determined among groups of Northern Thai women who had used estrogen-containing oral contraceptives (OCs) with or without multivitamin supplements through 13 cycles. Mean serum vitamin A values were elevated ~40% above those of control subjects (intrauterine contraceptive device (IUCD) users) during OC usage. Daily (one capsule) or periodic (two capsules 7 d/mo) multivitamin supplementation that included 1700 µg vitamin A per capsule did not significantly influence vitamin A serum values. The RDR test after 13 cycles was elevated in one individual who had taken OCs and the periodic multivitamin supplement. It reverted to normal after supplementation with vitamin A. A single high-dose vitamin A supplement (68 000 pg) did not change circulating levels of the vitamin. Among this population there is little evidence that use of estrogen-containing OCs for > 1 y resulted in a physiologically significant deterioration of vitamin A status. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Vitamin A
KW  - Oral contraceptives
KW  - Intrauterine contraceptives
KW  - Vitamins
KW  - Liver
KW  - assessment vitamin A status
KW  - oral contraceptives
KW  - RDR
N1  - Accession Number: 91731640; Amatayakul, Kosin 1,2,3; Underwood, Barbara A. 1,2,3; Ruckphaopunt, Somsri 1,2,3; Singkamani, Ratree 1,2,3; Linpisarn, Sukanya 1,2,3; Leelapat, Posri 1,2,3; Thanangkul, Ousa 1,2,3; Affiliations: 1: Research Institute for Health Sciences; 2: Department of Paediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 3: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: May1989, Vol. 49 Issue 5, p845; Subject Term: Vitamin A; Subject Term: Oral contraceptives; Subject Term: Intrauterine contraceptives; Subject Term: Vitamins; Subject Term: Liver; Author-Supplied Keyword: assessment vitamin A status; Author-Supplied Keyword: oral contraceptives; Author-Supplied Keyword: RDR; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ravussin, Eric
AU  - Bogardus, Clifton
T1  - Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989/05//
VL  - 49
IS  - 5
M3  - Article
SP  - 968
EP  - 975
SN  - 00029165
AB  - The article discusses the relationship of physical fitness, age and genetics to daily energy expenditure and fuel utilization. It notes the four components of 24-hour energy expenditure including the sleeping metabolic rate, thermic effect of food and the energy cost of physical activity. It mentions that basal metabolic rate has been proven to be correlated with body size and its small deficits or excess can add up to a large number of calories over time.
KW  - Energy metabolism
KW  - Caloric expenditure
KW  - Physical fitness
KW  - Aging
KW  - Physical activity
KW  - Basal metabolism
N1  - Accession Number: 91731665; Ravussin, Eric 1; Bogardus, Clifton 2; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ; 2: Department of Nutrition, Arizona State University, Tempe, AZ; Issue Info: May1989, Vol. 49 Issue 5, p968; Thesaurus Term: Energy metabolism; Subject Term: Caloric expenditure; Subject Term: Physical fitness; Subject Term: Aging; Subject Term: Physical activity; Subject Term: Basal metabolism; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rosenblum, Leonard A.
AU  - Kummer, Hans
AU  - Nadler, Ronald D.
AU  - Robinson, John
AU  - Suomi, Stephen J.
T1  - Interface of Field and Laboratory-Based Research in Primatology.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1989/05//
VL  - 18
IS  - 1
M3  - Article
SP  - 61
EP  - 64
SN  - 02752565
AB  - The article focuses on a conference "Interface of Laboratory and Field Based Research in Primatology" which was convened by the National Institute of Child Health and Human Development through its Laboratory of Comparative Ethology, IRP. This conference was designed to identify means of bridging an apparent chasm that separates some primatologists working in the field from some whose research is carried out primarily in laboratory settings. There was a clear consensus among all the conference participants that such a separation represents a detriment to the discipline. Moreover, it was agreed that our ability to clarify perceived differences in philosophy and approach and to overcome any research obstacles generated by these differences will influence not only the future progress of primatology but also the applicability of our work to the broader domain of biology.
KW  - PRIMATES
KW  - CLERGY conferences
KW  - PRIMATOLOGISTS
KW  - PHILOSOPHY
KW  - BIOLOGY
KW  - NATIONAL Institute of Child Health & Human Development (U.S.)
N1  - Accession Number: 12341179; Rosenblum, Leonard A. 1 Kummer, Hans 2 Nadler, Ronald D. 3 Robinson, John 4 Suomi, Stephen J. 5; Affiliation:  1: Department of Psychiatry,SUNY Health Science Center at Brooklyn.  2: Institute of Zoology, University of Zurich.  3: Yerkes Regional Primate Center, Emory University, Atlanta, Georgia.  4: Program for Studies in Tropical Conservation, University of Florida, Gainesville.  5: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1989, Vol. 18 Issue 1, p61; Subject Term: PRIMATES; Subject Term: CLERGY conferences; Subject Term: PRIMATOLOGISTS; Subject Term: PHILOSOPHY; Subject Term: BIOLOGY; Company/Entity: NATIONAL Institute of Child Health & Human Development (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Corbin, Stephen B.
T1  - Fluoridation Then and Now.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/05//
VL  - 79
IS  - 5
M3  - Editorial
SP  - 561
EP  - 563
PB  - American Public Health Association
SN  - 00900036
AB  - The author discusses on fluoridation of community water supplies as one of the most important public health measures. Fluoride has a substantial contribution to public health of all ages. The practice of fluoridating drinking water has grown dramatically and such undertakings reduced the prevalence of dental caries in children's teeth.
KW  - WATER fluoridation
KW  - DRINKING water
KW  - PUBLIC health
KW  - FLUORIDES
N1  - Accession Number: 4693435; Corbin, Stephen B. 1; Affiliation:  1: Disease Prevention Policy Analyst, National Institutes of Health, National Institute of Dental Research, Westwood Building, Room 538, 5333 Westbard Avenue, Bethesda, MD 20892; Source Info: May89, Vol. 79 Issue 5, p561; Subject Term: WATER fluoridation; Subject Term: DRINKING water; Subject Term: PUBLIC health; Subject Term: FLUORIDES; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moorman, Jeanne E.
AU  - Hernandez, Donald J.
T1  - Married-Couple Families With Step, Adopted, and Biological Children.
JO  - Demography
JF  - Demography
Y1  - 1989/05//
VL  - 26
IS  - 2
M3  - Article
SP  - 267
EP  - 278
SN  - 00703370
AB  - National estimates of the numbers of families with step, adopted, and biological children have not previously been developed. In this work, parent types for children in married-couple families were indirectly identified by using marriage and birth dates. Families were then classified by the types of children present. A large majority (79 percent) had only biological children; however, a significant minority (16 percent) had at least one stepchild and 4 percent had at least one adopted child. This analysis provides national estimates of the numbers and characteristics of married-couple families with step, adopted, and biological children. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUARDIAN & ward
KW  - FAMILIES
KW  - MARRIAGE
KW  - ADOPTED children
KW  - BIRTHFATHERS
KW  - STEPCHILDREN
N1  - Accession Number: 16799722; Moorman, Jeanne E. 1; Hernandez, Donald J. 2; Affiliations: 1: National Institute on Drug Abuse, Division of Epidemiology and Statistical Analysis, 5600 Fishers Lane, Rockville, Maryland 20772; 2: Population Division, U.S. Bureau of the Census, Washington, D.C. 20233; Issue Info: May1989, Vol. 26 Issue 2, p267; Subject Term: GUARDIAN & ward; Subject Term: FAMILIES; Subject Term: MARRIAGE; Subject Term: ADOPTED children; Subject Term: BIRTHFATHERS; Subject Term: STEPCHILDREN; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Aoyama, Toshifumi
AU  - Korzekwa, Kenneth
AU  - Nagata, Kiyoshi
AU  - Gillette, James
AU  - Gelboin, Harry V.
AU  - Gonzales, Frank J.
T1  - cDNA-directed expression of rat testosterone 7α-hydroxylase using the modified vaccinia virus, T7-RNA-polymerase system and evidence for 6α-hydroxylation and Δ6-testosterone formation.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/05//5/1/89
VL  - 181
IS  - 2
M3  - Article
SP  - 331
EP  - 336
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The modified vaccinia virus, T7-RNA-polymerase cDNA-expression system was used to express rat cytochrome P-450a. Various parameters such as host-cell type and density, and duration of infection were tested to optimize the level of expression of cytochrome P-450a enzyme activity. Cytochrome P-450a expressed from the cDNA sequence was exclusively incorporated into the membrane-containing portions of the cell lysates, as expected from its normal association in the liver endoplasmic reticulum. The enzyme displayed a carbonmonoxide-reduced-cytochrome-P-450a difference spectrum with a Sorer maximum of 450 nm. Activity measurements revealed that cytochrome P-450a produced three metabolites of testosterone; 7α-hydroxytestosterone and 6α-hydroxytestosterone and Δ6-testosterone at a ratio of about 38:1:1. Under the appropriate conditions, the vaccinia-virus, T7-RNA-polymerase system produces high levels of a single form of cytochrome P-450 in cells that are virtually devoid of endogenous cytochrome P-450. Analysis of the cytochrome P-450 in its natural membrane-bound state, as opposed to artificial-lipid reconstitution studies of purified enzymes, allows accurate and confident measurements of substrate specificities. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VACCINIA
KW  - CATTLE -- Virus diseases
KW  - CYTOCHROME P-450
KW  - CYTOCHROMES
KW  - DNA polymerases
KW  - ENDOPLASMIC reticulum
N1  - Accession Number: 13795219; Aoyama, Toshifumi 1 Korzekwa, Kenneth 2 Nagata, Kiyoshi 2 Gillette, James 2 Gelboin, Harry V. 1 Gonzales, Frank J. 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda  2: Laboratory of Chemical Pharmacology, National Institutes of Heart, Lung and Blood, National Institutes of Health, Bethesda; Source Info: 5/1/89, Vol. 181 Issue 2, p331; Subject Term: VACCINIA; Subject Term: CATTLE -- Virus diseases; Subject Term: CYTOCHROME P-450; Subject Term: CYTOCHROMES; Subject Term: DNA polymerases; Subject Term: ENDOPLASMIC reticulum; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Larson, David B.
AU  - Lyons, John S.
AU  - Hohmann, Ann A.
AU  - Beardsley, Robert S.
AU  - Huckeba, Wendy M.
AU  - Rabins, Peter V.
AU  - Lebowitz, Barry D.
T1  - A systematic review of nursing home research in three psychiatric journals: 1966–1985.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1989/05//
VL  - 4
IS  - 3
M3  - Article
SP  - 129
EP  - 134
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - This article presents the results of a systematic review of two decades of research on nursing home populations in three major psychiatric journals. The review indicates that very little psychiatric research has been undertaken in nursing home settings. The work that has been done is more often qualitative: case studies, program reports or reviews of the research, rather than quantitative research studies. The small amount of empirical research that has been published has suffered from sampling, design, and analytic shortcomings. Until recently, there has been little funded psychiatric research in nursing home setting, reflected in a worse than average disapproval rate for NIMH grant submissions involving nursing home populations. The implications of this review are discussed and recommendations are made for advancing this area of study among mental health professionals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NURSING care facilities
KW  - RESEARCH
KW  - NURSING home patients
KW  - PSYCHIATRIC research
KW  - LONG-term care facilities
KW  - GERIATRICS
KW  - Nursing homes
KW  - psychiatric disorders
KW  - research methods
N1  - Accession Number: 23633528; Larson, David B. 1 Lyons, John S. 2 Hohmann, Ann A. 1 Beardsley, Robert S. 3 Huckeba, Wendy M. 4 Rabins, Peter V. 4 Lebowitz, Barry D. 1; Affiliation:  1: National Institute of Mental Health  2: Northwestern University Medical School  3: University of Maryland Pharmacy School  4: Johns Hopkins University; Source Info: May1989, Vol. 4 Issue 3, p129; Subject Term: NURSING care facilities; Subject Term: RESEARCH; Subject Term: NURSING home patients; Subject Term: PSYCHIATRIC research; Subject Term: LONG-term care facilities; Subject Term: GERIATRICS; Author-Supplied Keyword: Nursing homes; Author-Supplied Keyword: psychiatric disorders; Author-Supplied Keyword: research methods; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hastings, Glare
AU  - Muir-Nash, Joanne
T1  - Validation of a Taxonomy of Ambulatory Nursing Practice.
JO  - Nursing Economic$
JF  - Nursing Economic$
Y1  - 1989/05//May/Jun89
VL  - 7
IS  - 3
M3  - Article
SP  - 142
EP  - 149
PB  - Jannetti Publications, Inc.
SN  - 07461739
AB  - The article discusses and focuses on the validation of a taxonomy of ambulatory nursing practice. Ambulatory care is considered to be a complex and challenging nursing specialty. Based on a survey of 33 ambulatory nursing administrators, roles and responsibilities of nurses in ambulatory care settings were addressed. Ambulatory care could be defined as care delivered to patients within a healthcare facility for those who do not stay overnight. The study provides a validated taxonomy which could be useful for managers, researchers and clinicians in order to develop patient classification systems.
KW  - OUTPATIENT medical care
KW  - TAXONOMY
KW  - NURSING -- Practice
KW  - MEDICAL care surveys
KW  - NURSE practitioners
KW  - PATIENTS
N1  - Accession Number: 12233087; Hastings, Glare 1 Muir-Nash, Joanne 2; Affiliation:  1: Director of Marketing and Communications, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD.  2: Clinical Nurse, Ambulatory Care, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD.; Source Info: May/Jun89, Vol. 7 Issue 3, p142; Subject Term: OUTPATIENT medical care; Subject Term: TAXONOMY; Subject Term: NURSING -- Practice; Subject Term: MEDICAL care surveys; Subject Term: NURSE practitioners; Subject Term: PATIENTS; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
T1  - Functional Electrical Stimulation: An Overview.
AU  - Hambrecht, F. Terry
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
Y1  - 1989/05//
VL  - 12
IS  - 5
SP  - 840
EP  - 843
SN  - 01478389
N1  - Accession Number: 17482606; Author: Hambrecht, F. Terry: 1 ; Author Affiliation: 1 National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health, Bethesda, Maryland; No. of Pages: 4; Language: English; Publication Type: Article; Update Code: 20050706
N2  - The development of future neural prostheses involves much more than connecting commercially available stimulators to disabled individuals. Safe and effective operation of prostheses requires fundamental studies of the electrode-tissue interface. The electrochemistry of the interface must be controlled to prevent toxic byproducts. Histopathological studies of stimulated tissue are necessary to establish safe limits of stimulation and to determine mechanisms of neural damage when it does occur. Electrophysiological studies elucidate which neural pathways are excited and help in the design of more selective electrode arrays. Biomaterials are required that protect the implant from the hostile environment of the body. Presently available materials are being improved and totally new materials are being developed. One of the goals of neural prostheses developers is a nonhermetic packaging material that can be applied to miniature implants without appreciably increasing their size. The techniques used to make integrated circuits on silicone substrates are ideally suited to making ultraminiature electrodes with self-contained electronic signal processing. Both integrated circuit stimulating and recording electrodes are being designed and fabricated. ABSTRACT FROM AUTHOR
KW  - *ELECTRIC stimulation
KW  - *ELECTROPHYSIOLOGY
KW  - *ELECTROTHERAPEUTICS
KW  - ELECTRODES
KW  - INTEGRATED circuits
KW  - SILICONES
KW  - biomaterials
KW  - electrodes
KW  - neural prostheses
KW  - neural stimulation
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
AU  - Taylor, Edward H.
T1  - Schizophrenia: Fire in the Brain.
JO  - Social Work
JF  - Social Work
Y1  - 1989/05//
VL  - 34
IS  - 3
M3  - Article
SP  - 258
EP  - 261
PB  - Oxford University Press / USA
SN  - 00378046
AB  - The article comments on "Biological Basis of Schizophrenia: The Evidence Reconsidered," Social Work 34 (May 1989), by David Cohen. The article brings out the new findings associated with Schizophrenia. David Cohen summarized the biological basis of Schizophrenia into the following six broad concepts: (1) no single abnormality is associated only with schizophrenia; (2) computerized axial tomography (CAT) scans have limited importance; (3) findings are based on small samples; (4) schizophrenia is difficult to diagnose; (5) neuroleptic drugs change brain functions, produce damage, and cause multiple side effects such as tardive dyskinesia (TD); and (6) the biological argument is not new. Cohen is correct to assume that neuroleptic drugs complicate analysis of brain data and behavioral observations. However, the notion that neurological studies cannot be trusted if these medications have been taken is incorrect. (NIMH) studies document that observable psychotic symptoms become more intense during drug-free periods and decrease when neuroleptic drugs are administered.
KW  - PSYCHIATRY
KW  - BRAIN diseases
KW  - SCHIZOPHRENIA
KW  - ANTIPSYCHOTIC drugs
KW  - PATHOLOGICAL psychology
KW  - BRAIN -- Ventricles
N1  - Accession Number: 5281502; Taylor, Edward H. 1; Affiliation:  1: Clinical Social Worker, Neuroscience Research Center, National Institute of Mental Health, 2700 Martin Luther King, Jr., Avenue, SE, Washington, DC 20032.; Source Info: May89, Vol. 34 Issue 3, p258; Subject Term: PSYCHIATRY; Subject Term: BRAIN diseases; Subject Term: SCHIZOPHRENIA; Subject Term: ANTIPSYCHOTIC drugs; Subject Term: PATHOLOGICAL psychology; Subject Term: BRAIN -- Ventricles; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06498-064
AN  - 2006-06498-064
AU  - Tancer, Manuel E.
AU  - Uhde, Thomas W.
T1  - Not All Anxieties are the Same.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1989/05//
VL  - 34
IS  - 5
SP  - 512
EP  - 512
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06498-064. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tancer, Manuel E.; Unit on Anxiety and Affective Disorders, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety; Anxiety Disorders; Treatment. Classification: Neuroses & Anxiety Disorders (3215); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Klein, D. F. (Ed); Fyer, A. J. (Ed); Gorman, J. M. (Ed); Liebowitz, M. R. (Ed). Anxiety=Basel, Switzerland: Karger, 1987. 195 pp. $65.00 (DM 117,-, SWF 98,-); 1987. References Available: Y. Page Count: 1. Issue Publication Date: May, 1989. 
AB  - Reviews the book, Anxiety by D. F. Klein (Ed.), A. J. Fyer, J. M. Gorman, and M. R. Liebowitz (1987). This book is a collection of papers written by researchers at the New York State Psychiatric Institute (NYSPl). The purpose of the collection, as stated is to share with the reader the 'current thinking of our research group about the nature and treatment of anxiety disorders.' The book has numerous typographical errors and minor errors in the spelling of names in the citations that detract from the quality of the text. In summary, with the reservation that the information in the book has a definite slant, this book is a good introduction to the literature and provides an extremely useful historical viewpoint for the emergent but still controversial theory that panic attacks represent a distinct type of pathological anxiety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - anxiety disorders
KW  - anxiety
KW  - treatment
KW  - 1989
KW  - Anxiety
KW  - Anxiety Disorders
KW  - Treatment
KW  - 1989
U2  - Klein, D. F. (Ed); Fyer, A. J. (Ed); Gorman, J. M. (Ed); Liebowitz, M. R. (Ed). (1987); Anxiety; Basel, Switzerland: Karger, 1987. 195 pp. $65.00 (DM 117,-, SWF 98,-); 3-8055-4488-X.
DO  - 10.1037/028075
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Stover, Ellen
T1  - NIMH Seeks Research on AIDS and Mental Health.
JO  - AIDS Education & Prevention
JF  - AIDS Education & Prevention
Y1  - 1989///Summer1989
VL  - 1
IS  - 2
M3  - Article
SP  - 166
EP  - 166
SN  - 08999546
AB  - The article focuses on the efforts of the National Institute of Mental Health (NIMH) to seek applications for research on mental health and behavioral aspects HIV infection and AIDS. NIMH has requested research grants, some in cooperation with Public Health Service agencies. The research areas undertaken by the NIMH includes: (1) effect of HIV infection on the central nervous system; (2) relationships between the brain, the immune system, and aspects of HIV infection; (3) behavior change and prevention in the reduction of HIV transmission; (4) treatment of HIV-related mental disorders; (5) risk management of HIV infection; (6) research training for those who wish to study HIV infection; and (7) institutional research training programs to study HIV infection.
KW  - AIDS (Disease)
KW  - HIV infections
KW  - Mental health
KW  - Pathological psychology
KW  - PREVENTION
KW  - TRANSMISSION
KW  - Medical research
KW  - Public health administration
KW  - Health services administration
KW  - National Institute of Mental Health (U.S.)
N1  - Accession Number: 19720655; Stover, Ellen 1; Affiliations: 1: Acting AIDS Coordinator, National Institute of Mental Health, Room 17C-04, 5600 Fishers Lane Rockville, MD 20857; Issue Info: Summer1989, Vol. 1 Issue 2, p166; Thesaurus Term: AIDS (Disease); Subject Term: HIV infections; Subject Term: Mental health; Subject Term: Pathological psychology; Subject Term: PREVENTION; Subject Term: TRANSMISSION; Subject Term: Medical research; Subject Term: Public health administration; Subject Term: Health services administration ; Company/Entity: National Institute of Mental Health (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Micozzi, Marc S.
AU  - Taylor, Philip R.
T1  - Reply to P Le François.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1989/06//
VL  - 49
IS  - 6
M3  - Letter to the Editor
SP  - 1330
EP  - 1331
SN  - 00029165
AB  - A response from the author on the comments of Le François on his article related to carotenodermia published in a 1988 issue of the periodical is presented.
KW  - Skin diseases
KW  - Carotenoids
N1  - Accession Number: 85657377; Micozzi, Marc S. 1; Taylor, Philip R. 2; Affiliations: 1: National Museum of Health and Medicine, Armed Forces Institute of Pathology, Washington, DC 20306-6000; 2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20854; Issue Info: Jun1989, Vol. 49 Issue 6, p1330; Subject Term: Skin diseases; Subject Term: Carotenoids; Number of Pages: 2p; Document Type: Letter to the Editor
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Harris, Tamara
AU  - Kovar, Mary Grace
AU  - Suzman, Richard
AU  - Kleinman, Joel C.
AU  - Feldmam, Jacob J.
T1  - Longitudinal Study of Physical Ability in the Oldest-Old.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 698
EP  - 702
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Based on 1984 data from the Longitudinal Study on Aging, one-third of White persons aged 80 or older living in the community (N = 1,791) were defined as having no difficulty in walking 1/4 of a mile, in lifting 10 pounds, in climbing 10 steps without resting, or in stooping, crouching or kneeling. Physical ability was associated with lower risk of death over two years mean follow-up; Relative odds (RO) = .4 (95 percent confidence interval = .4, .6) and in survivors, lower utilization of hospitals RO = .4 (CI = .3, .7), physicians RO = .6 (CI = .5, .8) and nursing homes RO = .3 (CI = .2, .5) compared with those having difficulty on any of the four functional measures included in the definition of physical ability.  Fifty percent of the women and 42 percent of the men physically able at the time of the baseline survey in 1984 remained physically able at follow-up. Continued physical ability in this group was associated with never having had cardiovascular disease RO = 2.1, (CI = 1.2, 3.7), never having had arthritic complaints RO = 1.9 (CI = 1.2, 2.7), a body mass index < the 75th percentile (RO = 1.8 (CI = 1.2, 2.9), younger age (for each decade of age, RO = 2.0 (CI = 1.1, 3.6), and higher level of education (> 13 years versus 0-6 years) RO = 2.4 (CI = 1.2, 4.7). These correlates include factors amenable to preventive measures and highlight the need to consider the heterogeneity of the oldest-old in formulating programs aimed at prevention and postponement of disability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GERIATRIC assessment
KW  - PHYSICAL fitness testing
KW  - OLDER people -- Physiology
KW  - LONGITUDINAL method
KW  - DISABILITY evaluation
KW  - OLD age
KW  - WALKING -- Physiological aspects
KW  - AGING -- Physiological aspects
KW  - WHITES
KW  - PHYSIOLOGY
KW  - PHYSIOLOGICAL aspects
N1  - Accession Number: 4695728; Harris, Tamara 1 Kovar, Mary Grace 1 Suzman, Richard 2 Kleinman, Joel C. 1 Feldmam, Jacob J. 1; Affiliation:  1: National Center for Health Statistics, Hyattsville, Maryland.  2: National Institute on Aging, Bethesda, Maryland.; Source Info: Jun89, Vol. 79 Issue 6, p698; Subject Term: GERIATRIC assessment; Subject Term: PHYSICAL fitness testing; Subject Term: OLDER people -- Physiology; Subject Term: LONGITUDINAL method; Subject Term: DISABILITY evaluation; Subject Term: OLD age; Subject Term: WALKING -- Physiological aspects; Subject Term: AGING -- Physiological aspects; Subject Term: WHITES; Subject Term: PHYSIOLOGY; Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Guralnik, Jack M.
AU  - Kaplan, George A.
T1  - Predictors of Healthy Aging: Prospective Evidence from the Alameda County Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 703
EP  - 708
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Long-term predictors of high levels of physical functioning were examined in a representative sample of Alameda County, California residents followed from 1965 through 1984. The cohort investigated in this study was born between 1895 and 1919, with survivors being age 65 to 89 at the time of follow-up. A scale of physical functioning w as developed from a comprehensive set of questionnaire items which assessed the full spectrum of physical functioning. Those scoring in the top 20 percent, defined as healthy aging, were compared to the remainder of the cohort, including those who died and those with lower levels of functioning at follow-up. After adjustment for age and functional status at baseline, the following variables were predictive of high functioning at follow-up 19 years later: race (those not Black), higher family income level, absence of hypertension, absence of arthritis, absence of back pain, being a non-smoker, having normal weight, and consuming moderate amounts of alcohol. Sex did not predict high function because of the counterbalancing effects of higher survival in females but greater likelihood of high functioning among surviving males. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GERIATRIC assessment
KW  - AGING -- Physiological aspects
KW  - OLD age
KW  - PHYSICAL fitness testing
KW  - OLDER people -- Physiology
KW  - COHORT analysis
KW  - HEALTH surveys -- United States
KW  - AGE groups
KW  - PHYSIOLOGICAL aspects
KW  - CALIFORNIA
N1  - Accession Number: 4695738; Guralnik, Jack M. 1 Kaplan, George A. 2; Affiliation:  1: National Institute on Aging, California Department of Health Services.  2: Human Population Laboratory, California Department of Health Services.; Source Info: Jun89, Vol. 79 Issue 6, p703; Subject Term: GERIATRIC assessment; Subject Term: AGING -- Physiological aspects; Subject Term: OLD age; Subject Term: PHYSICAL fitness testing; Subject Term: OLDER people -- Physiology; Subject Term: COHORT analysis; Subject Term: HEALTH surveys -- United States; Subject Term: AGE groups; Subject Term: PHYSIOLOGICAL aspects; Subject Term: CALIFORNIA; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Albanes, Demetrius
AU  - Blair, Aaron
AU  - Taylor, Philip R.
T1  - Cost-Effectiveness of Antibiotic Prophylaxis for Dental Procedures in Patients with Artificial Joints.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 739
EP  - 743
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We performed a cost-effectiveness analysis to evaluate whether patients with artificial joints should take penicillin, erythromycin, or no antibiotics before dental procedures. We modeled the risk of anaphylaxis from penicillin, the risks and consequences of an artificial joint infection, and the actual variable costs of hospitalization and antibiotics.  Penicillin prophylaxis is slightly less expensive than erythromycin prophylaxis but is both more expensive and less effective than no prophylaxis. Erythromycin prophylaxis, the most effective, is the most expensive strategy. The marginal cost effectiveness of erythromycin prophylaxis compared to no prophylaxis is $12,900 per quality-adjusted year of life saved. Sensitivity analysis demonstrates that the risk of developing a joint infection is the key parameter in the analysis.  Based on our estimated risk of developing a joint infection, the cost-effectiveness of antibiotic prophylaxis with erythromycin compares favorably with other medical interventions. Thus, until a definitive study to quantify the risk is conducted, patients with artificial joints should take prophylactic erythromycin when they undergo dental procedures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL prophylaxis
KW  - ANTIBIOTICS -- Physiological effect
KW  - COST effectiveness
KW  - DENTAL hygiene
KW  - ARTIFICIAL joints
KW  - ORTHOPEDIC implants
KW  - ANAPHYLAXIS
KW  - ERYTHROMYCIN
KW  - PENICILLIN
KW  - THERAPEUTIC use
N1  - Accession Number: 4695810; Albanes, Demetrius 1 Blair, Aaron 1 Taylor, Philip R. 2; Affiliation:  1: Center Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Cancer Institute, National Institute of Health, EPN 211, 9000 Rockville Pike, Bethesda, MD 20892.  2: Environmental Epidemiology Branch, Division of Cancer Etiology, NCI, NIH.; Source Info: Jun89, Vol. 79 Issue 6, p739; Subject Term: DENTAL prophylaxis; Subject Term: ANTIBIOTICS -- Physiological effect; Subject Term: COST effectiveness; Subject Term: DENTAL hygiene; Subject Term: ARTIFICIAL joints; Subject Term: ORTHOPEDIC implants; Subject Term: ANAPHYLAXIS; Subject Term: ERYTHROMYCIN; Subject Term: PENICILLIN; Subject Term: THERAPEUTIC use; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Albanes, Demetrius
AU  - Blair, Aaron
T1  - Physical Activity and Risk of Cancer in the NHANES I Population.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 744
EP  - 750
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We studied the relation between self-reported physical activity and cancer in the first National Health and Nutrition Examination Survey (NHANES I) cohort, originally examined between 1971-75, and followed prospectively through the Epidemiologic Follow-up Study (NHEFS), conducted between 1982-84. Among 5,138 men and 7,407 women 25-74 years old, for nonrecreational activity we observed increased risk of cancer among inactive individuals compared to very active persons (for men, relative risk [RR] 1.8, 95% confidence interval [CI] = 1.4, 2.4; for women RR 1.3, 95% CI = 1.0, 1.8). These findings were unchanged after adjustment for cigarette smoking, body mass index (BMI), and other potential confounders. Sites which demonstrated stronger inactivity-cancer associations included colorectum (RR 1.6,95% CI = 0.7, 3.5) and lung (RR 1.6; 95% CI = 1.2, 3.5) among men, and breast (post-menopausal) (RR 1.7; 95% CI = 0.8, 2.9) and cervix (RR 5.2; 95% CI = 1.4, 14.5) among women, although these findings for women were based on relatively few cases. The association between inactivity and cancer was greater among persons of moderate (or lower) BMI, those cases occurring three or more years after baseline, and, in women, those more than 60 years old. In contrast, recreational exercise showed little relation to cancer, with the exception of prostate cancer. The results suggest that inactive individuals are at increased risk of cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER research
KW  - HEALTH risk assessment
KW  - PHYSICAL fitness testing
KW  - ACTIVITIES of daily living
KW  - HEALTH surveys
KW  - EVALUATION
KW  - CANCER prevention
KW  - BODY mass index
KW  - CANCER in women
KW  - PREVENTIVE medicine
N1  - Accession Number: 4695821; Albanes, Demetrius 1 Blair, Aaron 1; Affiliation:  1: Center Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Cancer Institute, National Institute of Health, EPN 211, 9000 Rockville Pike, Bethesda, MD 20892.; Source Info: Jun89, Vol. 79 Issue 6, p744; Subject Term: CANCER research; Subject Term: HEALTH risk assessment; Subject Term: PHYSICAL fitness testing; Subject Term: ACTIVITIES of daily living; Subject Term: HEALTH surveys; Subject Term: EVALUATION; Subject Term: CANCER prevention; Subject Term: BODY mass index; Subject Term: CANCER in women; Subject Term: PREVENTIVE medicine; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Liu, Ingrid Y.
AU  - White, Lon
AU  - LaCroix, Andrea Z.
T1  - The Association of Age-Related Macular Degeneration and Lens Opacities in the Aged.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 765
EP  - 769
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Data from 3,087 persons age 45 or older in the National Health and Nutrition Survey, 1971-74, showed that subjects with lens opacifying disease had an increased odds for age-related macular degeneraton (AMD) compared to those who had no lens opacities. The crude odds ratio for aphakic patients was 4.6 (95% CI = 2.5, 8.6). The association remained after controlling for age, sex, and systolic blood pressure (a common risk factor) in a logistic regression model. These data are consistent with the hypothesis that light-reduced damage may contribute to both lens and retinal disease and suggest that cataract extraction without implantation of ultra-violet/blue light absorbing intraocular lens may place subjects at increased risk of AMD. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RETINAL degeneration
KW  - OLDER people -- Diseases
KW  - RETINAL diseases
KW  - AGING -- Physiological aspects
KW  - DEGENERATION (Pathology)
KW  - OPACITY (Optics)
KW  - VISION disorders in old age
KW  - OLD age
KW  - GERIATRIC ophthalmology
KW  - PHYSIOLOGICAL aspects
N1  - Accession Number: 4695856; Liu, Ingrid Y. 1 White, Lon 1 LaCroix, Andrea Z. 1; Affiliation:  1: Epidemiology, Demography, and Biometry Program, National Institute on Aging.; Source Info: Jun89, Vol. 79 Issue 6, p765; Subject Term: RETINAL degeneration; Subject Term: OLDER people -- Diseases; Subject Term: RETINAL diseases; Subject Term: AGING -- Physiological aspects; Subject Term: DEGENERATION (Pathology); Subject Term: OPACITY (Optics); Subject Term: VISION disorders in old age; Subject Term: OLD age; Subject Term: GERIATRIC ophthalmology; Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Perez-Stabel, Eliseo J.
AU  - McMillen, Marilyn Miles
AU  - Harris, Maureen I.
AU  - Juarez, Ramaldo Z.
AU  - Knowler, William C.
AU  - Stern, Michael P.
AU  - Haynes, Suzanne G.
T1  - Self-Reported Diabetes in Mexican Americans: HHANES 1982-84.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 770
EP  - 772
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: In the Hispanic Health and Nutrition Examination Survey (HHANES) of 3,928 Mexican Americans ages 20-74 years, the age-adjusted prevalence of self-reported diabetes was 6.8 percent among men and 7.6 percent among women. Comparable age-adjusted rates for the US population in a national survey were 2.9 percent in men and 3.8 percent in women. The prevalence of diabetes in Mexican Americans is greater in older age groups, was similar in men and women, and among women only was inversely associated with education. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SELF-evaluation
KW  - DIABETES
KW  - MEXICAN Americans -- Health
KW  - DIABETES in old age
KW  - OLDER people -- Diseases
KW  - HEALTH education of women
KW  - HEALTH surveys
KW  - AGE distribution (Demography)
KW  - POPULATION aging
N1  - Accession Number: 4695860; Perez-Stabel, Eliseo J. 1 McMillen, Marilyn Miles 2 Harris, Maureen I. 3 Juarez, Ramaldo Z. 4 Knowler, William C. 5 Stern, Michael P. 6 Haynes, Suzanne G. 2; Affiliation:  1: Division of General Internal Medicine, Department of Medicine, University of California  2: Medical Statistics branch of National Center for Health Statistics  3: National Diabetes Data Group. National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Washington  4: Pan American University, Edinburg, Texas  5: NIDDKD/NIH in Phoenix, Arizona  6: University of Texas Health Science Center, San Antonio; Source Info: Jun89, Vol. 79 Issue 6, p770; Subject Term: SELF-evaluation; Subject Term: DIABETES; Subject Term: MEXICAN Americans -- Health; Subject Term: DIABETES in old age; Subject Term: OLDER people -- Diseases; Subject Term: HEALTH education of women; Subject Term: HEALTH surveys; Subject Term: AGE distribution (Demography); Subject Term: POPULATION aging; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mayer, William J.
AU  - McWhorter, William P.
T1  - Black/White Differences in Non-treatment of Bladder Cancer Patients and Implications for Survival.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/06//
VL  - 79
IS  - 6
M3  - Article
SP  - 772
EP  - 775
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Analysis of 20,764 White and 882 Black bladder cancer patients diagnosed during 1978-85 indicates that Black patients were more likely than White patients to go untreated following diagnosis after adjustment for age- and stage-at-diagnosis, sex, and tumor histology (OR = 1.80, 95% CI = 1.33, 2.43). Treatment status was found to be a significant predictor of five-year survival after adjustment (treated/untreated odds ratio = 3.16, 95% CI = 2.08, 4.79). Results suggest that differences in initial therapy may contribute to the survival differential between Black and White bladder cancer patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLADDER cancer
KW  - WHITES
KW  - HEALTH
KW  - BLACKS -- Health
KW  - CANCER -- Mortality
KW  - CANCER patients
KW  - CANCER treatment
KW  - THERAPEUTICS
KW  - CLINICAL medicine
KW  - SOCIAL aspects
N1  - Accession Number: 4695865; Mayer, William J. 1 McWhorter, William P. 1; Affiliation:  1: Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Jun89, Vol. 79 Issue 6, p772; Subject Term: BLADDER cancer; Subject Term: WHITES; Subject Term: HEALTH; Subject Term: BLACKS -- Health; Subject Term: CANCER -- Mortality; Subject Term: CANCER patients; Subject Term: CANCER treatment; Subject Term: THERAPEUTICS; Subject Term: CLINICAL medicine; Subject Term: SOCIAL aspects; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Filley, E.
AU  - Andreoli, A.
AU  - Steele, J.
AU  - Waters, M.
AU  - Wagner, D.
AU  - Nelson, D.
AU  - Tung, K.
AU  - Rademacher, T.
AU  - Dwek, R.
AU  - Rook, G. A. W.
T1  - A transient rise in agalactosyl IgG correlating with free interleukin 2 receptors, during episodes of erythema nodosum leprosum.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1989/06//
VL  - 76
IS  - 3
M3  - Article
SP  - 343
EP  - 347
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosaminc and not galaclose (%GO) has previously been shown to be raised in rheumatoid arthritis (RA), Crohn's disease (CD) and tuberculosis (Tb), but to be normal in sarcoidosis (SA). and in both lepromatous and tuberculoid leprosy. However we have now studied %GO in sequential serum samples collected from lepromatous leprosy patients undergoing episodes of erythema nodosum leprosum (ENL). During ENL %GO is transiently raised, and this rise parallels an increase in circulating interleukin 2 receptors (IL-2R). These findings confirm that changes in T cell function occur during ENL. Moreover it appears that %GO rises when there is, simultaneously, T-cell-mediated tissue damage and an acute phase response (RA, CD, Tb, ENL), but not when there is an acute phase response without major T cell involvement, or chronic T cell activity alone (SA, and tuberculoid leprosy). We suggest therefore that %GO is an indicator of a type of T cell activity with broad immunopathological implications. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHEUMATOID arthritis
KW  - OLIGOSACCHARIDES
KW  - GLUCOSIDES
KW  - GLYCOASPARAGINASE
KW  - TUBERCULOSIS
KW  - T cells
KW  - LEPROSY
KW  - SERUM
KW  - agalactosyl IgG
KW  - erythema nodosum leprosum
KW  - interleukin 2 receptor
KW  - leprosy
KW  - tuberculosis
N1  - Accession Number: 16002989; Filley, E. 1 Andreoli, A. 1 Steele, J. 1 Waters, M. 1 Wagner, D. 2 Nelson, D. 2 Tung, K. 3 Rademacher, T. 4 Dwek, R. 4 Rook, G. A. W. 1; Affiliation:  1: Department of Medical Microbiology, University College and Middlesex School of Medicine, London.  2: Immunophysiology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda.  3: Washington University, School of Medicine, Departments of Pathology and Medicine, St. Louis.  4: Glycobiology Unit, Department of Biochemistry, Oxford.; Source Info: Jun1989, Vol. 76 Issue 3, p343; Subject Term: RHEUMATOID arthritis; Subject Term: OLIGOSACCHARIDES; Subject Term: GLUCOSIDES; Subject Term: GLYCOASPARAGINASE; Subject Term: TUBERCULOSIS; Subject Term: T cells; Subject Term: LEPROSY; Subject Term: SERUM; Author-Supplied Keyword: agalactosyl IgG; Author-Supplied Keyword: erythema nodosum leprosum; Author-Supplied Keyword: interleukin 2 receptor; Author-Supplied Keyword: leprosy; Author-Supplied Keyword: tuberculosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Good, M. F.
AU  - Powell, L. W.
AU  - Halliday, J. W.
T1  - IL-2 and IL-4 can co-modulate the generation of cytotoxic T cells through CD8- CD4- splenic lymphocytes.
JO  - Immunology
JF  - Immunology
Y1  - 1989/06//
VL  - 67
IS  - 2
M3  - Article
SP  - 225
EP  - 230
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Following activation with concanavalin A (Con A), murine T cells are able to suppress the generation of allospecific cytotoxic T lymphocytes (CTL). We have analysed the phenotype, tissue distribution, and mode of action of these cells in an effort to understand further the regulation of CTL-mediated immunity. The precursors of such cells are rare (1 cell per 70,000 spleen cells being able to suppress the generation of a particular allospecific response), but are much more abundant in the spleen than in the thymus. By the use of cytotoxic antibodies, we have been able to demonstrate that the splenic precursors of such cells are Thy-1.2+, CD4-, CD8- but, following activation with Con A, these cells acquire the CD8 marker. Cellular suppression by these lymphocytes is dramatically increased in the presence of the Th2-derived lymphokine, IL-4, whereas IL-2, the Th1-derived lymphokine. significantly augments the generation of CTL in a mixed lymphocyte culture even though relative suppression is still evident in the presence of Con A-activated lymphocytes. Suppression is not due to overcrowding of a cell culture since adding Con A-activated cells to an A anti-B + C culture often resulted in the suppression of the A anti-B response but not the A anti-C response, or vice versa. Suppression appears to require cellular interaction since supernatants from Con A-activated lymphocytes are unable to mediate suppression. Such cells may play an important intermediate role in homeostasis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - INTERLEUKIN-4
KW  - CD antigens
KW  - T cells
KW  - INTERLEUKINS
KW  - LYMPHOKINES
KW  - CELL surface antigens
KW  - FC receptors
N1  - Accession Number: 13358949; Good, M. F. 1,2 Powell, L. W. 2 Halliday, J. W. 2; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Department of Medicine, University of Queensland, Brisbane, Australia; Source Info: Jun89, Vol. 67 Issue 2, p225; Subject Term: INTERLEUKIN-2; Subject Term: INTERLEUKIN-4; Subject Term: CD antigens; Subject Term: T cells; Subject Term: INTERLEUKINS; Subject Term: LYMPHOKINES; Subject Term: CELL surface antigens; Subject Term: FC receptors; Number of Pages: 6p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Milo, George E.
AU  - Yohn, Joseph
AU  - Schuller, David
AU  - Noyes, Inge
AU  - Lehman, Teresa
T1  - Comparative Stages of Expression of Human Squamous Carcinoma Cells and Carcinogen Transformed Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/06//
VL  - 92
IS  - 6
M3  - Article
SP  - 848
EP  - 853
SN  - 0022202X
AB  - The mouse monoclonal antibody OSU 22-3 was prepared using cells from a squamous cell carcinoma (SCC) as an immunogen. This antibody reacts with an antigen found on squamous cell carcinomas but does not react with normal keratinocytes. This antibody and two antibodies that react with normal keratinocytes were used as markers of malignant and normal phenotypes. These markers were used to evaluate several spontaneous and carcinogen initiated SCC tumors and to identify the expression of an antigen associated with a malignant phenotype. A variety of subpopulations in carcinogen initiated tumors and spontaneous SCC tumors were noted. The subpopulations that reacted only with MoAb OSU 22-3 exhibited features of anchorage independent growth and cellular invasiveness, and formed progressively growing tumors in nude mice. Other SCC spontaneous tumor cell subpopulations reacted with the antibodies associated with normal keratinocytes. These cells did not proliferate in vitro and did not form tumors in the nude mouse. There were other carcinogen transformed cells which reacted with MoAb OSU 22-3 but not with the antibodies associated with normal keratinocytes. These cells exhibited anchorage independent growth and cellular invasiveness but did not form tumors in nude mice. We conclude from this work that human SCC tumors contain multiple cell populations. These cell populations have varied growth properties and express surface antigens that may indicate their malignant vigor. Carcinogen transformed keratinocytes do exhibit some of the characteristics of SCC tumor phenotypes but not the property of malignant progressively growing cells on a routine and consistent basis. This feature is transiently and inconsistently expressed in a surrogate host by populations prepared from spontaneous SSC tumors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUAMOUS cell carcinoma
KW  - CARCINOGENS
KW  - KERATINOCYTES
KW  - MONOCLONAL antibodies
KW  - IMMUNOGENETICS
KW  - PHENOTYPE
N1  - Accession Number: 12696872; Milo, George E. 1 Yohn, Joseph Schuller, David 2 Noyes, Inge 1 Lehman, Teresa 3; Affiliation:  1: Departments of Physiological Chemistry and the Comprehensive Cancer Center.  2: Department of Otolaryngology, The Ohio State Urüvenitv, Columbus, Ohio.  3: Laboratory of Human Carcinogenesis, National Institutes of Health, Bethesda. Maryland, U.S.A.; Source Info: Jun89, Vol. 92 Issue 6, p848; Subject Term: SQUAMOUS cell carcinoma; Subject Term: CARCINOGENS; Subject Term: KERATINOCYTES; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGENETICS; Subject Term: PHENOTYPE; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12696872
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Clerici, Mario
AU  - Stocks, Naomi I.
AU  - Zajac, Robert A.
AU  - Boswell, R. Neal
AU  - Bernstein, Denise C.
AU  - Mann, Dean L.
AU  - Shearer, Gene M.
AU  - Berzofsky, Jay A.
T1  - Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals.
JO  - Nature
JF  - Nature
Y1  - 1989/06//6/1/1989
VL  - 339
IS  - 6223
M3  - Letter
SP  - 383
EP  - 385
SN  - 00280836
AB  - T lymphocytes from mice¹ and healthy humans² immunized against the human immunodeficiency virus (HIV) envelope have recently been shown to recognize two antigenic regions of the gp160 HIV-envelope protein which have been located on the basis of amphipathicity3-6. In HIV-infected humans, T-cell proliferative responses are lost soon after infection7,8. Here we demonstrate that interleukin-2 production is often retained even when proliferative activity is absent, and that it can be used to monitor T-helper cell responses by HIV-seropositive donors. We use this approach to investigate the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gpl60 peptides and to influenza A virus, an antigen requiring intact CD4 T-helper cell function. As many as 67% of the HIV-seropositive donors who retain responsiveness to influenza A virus respond to a single peptide, and 85-90% responded to at least one of the peptides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV (Viruses)
KW  - Letters to the editor
KW  - Peptides
KW  - Influenza A virus
KW  - T cells
KW  - HIV-positive persons
KW  - Interleukin-2
N1  - Accession Number: 22830551; Clerici, Mario 1; Stocks, Naomi I. 1; Zajac, Robert A. 2; Boswell, R. Neal 2; Bernstein, Denise C. 1; Mann, Dean L. 3; Shearer, Gene M. 1; Berzofsky, Jay A. 4; Affiliations: 1: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA; 2: HIV Unit/SGHMMM, Wilford Hall, Lackland AFB, Texas 28236, USA; 3: Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA; 4: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA; Issue Info: 6/1/1989, Vol. 339 Issue 6223, p383; Thesaurus Term: HIV (Viruses); Subject Term: Letters to the editor; Subject Term: Peptides; Subject Term: Influenza A virus; Subject Term: T cells; Subject Term: HIV-positive persons; Subject Term: Interleukin-2; Number of Pages: 3p; Illustrations: 3 Charts, 3 Graphs; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Chaudhary, Vijay K.
AU  - Queen, Cary
AU  - Junghans, Richard P.
AU  - Waldmann, Thomas A.
AU  - FitzGerald, David J.
AU  - Pastan, Ira
T1  - A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin.
JO  - Nature
JF  - Nature
Y1  - 1989/06//6/1/1989
VL  - 339
IS  - 6223
M3  - Letter
SP  - 394
EP  - 397
SN  - 00280836
AB  - Antibodies and growth factors have been chemically coupled to different toxins to produce cytotoxic molecules that selectively kill cells bearing appropriate antigens or receptors1,2. Antibody-toxin conjugates (immunotoxins) produced using conventional chemical coupling techniques have several undesirable characteristics. The smallest binding unit of an antibody is an Fv fragment which consists of a light and heavy chain variable domain. Recently, active single chain Fv fragments of antibodies have been produced in Esherichia coli by attaching the light and heavy chain variable domains together with a peptide linker3,4. Here we describe the construction and expression in E. coli of a single chain antibody toxin fusion protein, anti-Tac(Fv)-PE40, in which the variable regions of anti-Tac, a monoclonal antibody to the p55 subunit of the human interleukin-2 receptor5, arc joined in peptide linkage to PE40, a modified form of Pseudomonas exotoxin lacking its binding domain. Anti-Tac(Fv)-PE40 was very cytotoxic to two interleukin-2 receptor-bearing human cell lines but was not cytotoxic to receptor-negative cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Letters to the editor
KW  - Interleukin-2
KW  - Pseudomonas
KW  - Cell lines
KW  - Monoclonal antibodies
KW  - Growth factors
KW  - Antibody-toxin conjugates
N1  - Accession Number: 22830581; Chaudhary, Vijay K. 1; Queen, Cary 2; Junghans, Richard P. 3; Waldmann, Thomas A. 3; FitzGerald, David J. 1; Pastan, Ira 1; Affiliations: 1: Laboratory of Molecular Biology, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Protein Design Labs, 3181 Porter Drive, Palo Alto, California 94304, USA; 3: Metabolism Branch, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: 6/1/1989, Vol. 339 Issue 6223, p394; Thesaurus Term: Escherichia coli; Subject Term: Letters to the editor; Subject Term: Interleukin-2; Subject Term: Pseudomonas; Subject Term: Cell lines; Subject Term: Monoclonal antibodies; Subject Term: Growth factors; Subject Term: Antibody-toxin conjugates; Number of Pages: 4p; Illustrations: 2 Diagrams, 1 Chart, 3 Graphs; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06621-012
AN  - 2006-06621-012
AU  - Lamb, Michael E.
T1  - Fathers' Role or Father's Roles?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1989/06//
VL  - 34
IS  - 6
SP  - 551
EP  - 551
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06621-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Family; Father Child Relations; Fathers; Parental Role; Parenting Skills. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Bronstein, Phyllis (Ed); Cowan, Carolyn Pape (Ed). Fatherhood Today: Men's Changing Role in the Family=New York: Wiley, 1988. 364 pp. $39.95; 1988. Page Count: 1. Issue Publication Date: Jun, 1989. 
AB  - Reviews the book, Fatherhood Today: Men's Changing Role in the Family edited by Phyllis Bronstein and Carolyn Pape Cowan (1988). Of the 19 chapters, 7 are organized into a section concerned with fathers and father-child relationships in two-parent families. Only one provides an account of descriptive research on father-infant relationships (Yogman, Cooley, and Kindlon) and another of paternal effects on children (Bronstein)--the two 'traditional' foci for research on fathers. Two other chapters cover the increasingly insightful work on the motivation for and psychological appraisals of fatherhood by fathers (P. Cowan; Daniels and Weingarten), while another deals with the correlates and possible antecedents of variations in paternal involvement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - paternal involvement
KW  - father-infant relationships
KW  - paternal effects
KW  - fathers role
KW  - 1989
KW  - Family
KW  - Father Child Relations
KW  - Fathers
KW  - Parental Role
KW  - Parenting Skills
KW  - 1989
U2  - Bronstein, Phyllis (Ed); Cowan, Carolyn Pape (Ed). (1988); Fatherhood Today: Men's Changing Role in the Family; New York: Wiley, 1988. 364 pp. $39.95; 0-471-83627-3.
DO  - 10.1037/031146
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Proton Radiation Therapy Effective.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/06/09/
VL  - 261
IS  - 22
M3  - Article
SP  - 3214
EP  - 3214
SN  - 00987484
AB  - Reports on the effectiveness of proton radiation therapy in the treatment of chordoma or low-grade chondrosarcoma of the base of the skull. Local control rate and actuarial local control rate in patients receiving the therapy.
KW  - RADIATION
KW  - PROTONS
KW  - CHORDOMA
KW  - SARCOMA
KW  - SKULL -- Diseases
N1  - Accession Number: 10982500; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: RADIATION; Subject Term: PROTONS; Subject Term: CHORDOMA; Subject Term: SARCOMA; Subject Term: SKULL -- Diseases; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Effects of Perinatal Exposure to PCBs.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/06/09/
VL  - 261
IS  - 22
M3  - Article
SP  - 3214
EP  - 3214
SN  - 00987484
AB  - Studies the effects of perinatal exposure to polychlorinated biphenyls (PCBs).  Relationship found between transplacental exposure to PCBs and lower psychomotor scores in the first year of life.
KW  - POLYCHLORINATED biphenyls
KW  - BIPHENYL compounds
N1  - Accession Number: 10982501; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: POLYCHLORINATED biphenyls; Subject Term: BIPHENYL compounds; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - New Insights into Pathogenesis of Hepatic Encephalopathy.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/06/09/
VL  - 261
IS  - 22
M3  - Article
SP  - 3214
EP  - 3214
SN  - 00987484
AB  - Investigates the role of gamma-aminobutyric acid-benzodiazepine (BZDZ) receptor complex in the pathogenesis of hepatic encephalopathy.  Use of animal models to show that elevated levels of a compound exhibiting BZDZ receptor agonist properties are associated with hepatic encephalopathy.
KW  - GABA
KW  - BENZODIAZEPINES
KW  - HEPATIC encephalopathy
N1  - Accession Number: 10982502; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: GABA; Subject Term: BENZODIAZEPINES; Subject Term: HEPATIC encephalopathy; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Study of Cardiovascular Risk Factors in Older Adults.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/06/09/
VL  - 261
IS  - 22
M3  - Article
SP  - 3214
EP  - 3214
SN  - 00987484
AB  - Announces that start of a multicenter epidemiological study to determine cardiovascular risk factors in older adults.
KW  - CARDIOVASCULAR diseases -- Risk factors
KW  - HEART diseases -- Risk factors
N1  - Accession Number: 10982503; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: CARDIOVASCULAR diseases -- Risk factors; Subject Term: HEART diseases -- Risk factors; Number of Pages: 1/9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schatzkin, Arthur
AU  - Greenwald, Peter
AU  - Byar, David P.
AU  - Clifford, Carolyn K.
T1  - The Dietary Fat-Breast Cancer Hypothesis is Alive.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/06/09/
VL  - 261
IS  - 22
M3  - Article
SP  - 3284
EP  - 3287
SN  - 00987484
AB  - Discusses the need for studies to examine the dietary fat-breast cancer hypothesis.  Laboratory investigations in humans that examine possible mechanisms for the effects of fat; Large, prospective epidemiologic studies; Randomized, controlled diet trials.
KW  - FAT
KW  - BREAST cancer
N1  - Accession Number: 10982511; Schatzkin, Arthur 1 Greenwald, Peter 1 Byar, David P. 1 Clifford, Carolyn K. 1; Affiliation:  1: Division of Cancer Prevention and Control National Cancer Institute; Source Info: 6/9/89, Vol. 261 Issue 22, p3284; Subject Term: FAT; Subject Term: BREAST cancer; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goddard, Colin
AU  - Aquino, Angelo
AU  - Glazer, Robert I.
AU  - Felsted, Ronad L.
T1  - Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/06/15/
VL  - 182
IS  - 2
M3  - Article
SP  - 323
EP  - 326
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The N-terminal p17gag protein of the human immunodeficiency virus has been shown to incorporate radioactivity following labelling of infected cell lines with [³H]myristic acid. We investigated p17gag to determine whether the incorporated radioactivity was the consequence of N-terminal myristoylation. The virus was purified by density gradient centrifugation after labelling chronically infected H9 cells with [³H]myristic acid. The p17gag was isolated by immunoprecipitation and subjected to partial acid hydrolysis. [³H]Myristoylglycine generated by the hydrolysis was derivatized to 4-(p-nitrobenzylidene)-2-tridecanoyloxazol-5-one and identified against a co-eluting, derivatized, unlabelled N-myristoylglycine standard by reverse-phase high-performance liquid chromatography. This study unequivocally demonstrates that p17gag is an N-myristoylated protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV (Viruses)
KW  - PROTEINS
KW  - CELL lines
KW  - HYDROLYSIS
KW  - LIQUID chromatography
KW  - BIOCHEMISTRY
N1  - Accession Number: 13793513; Goddard, Colin 1 Aquino, Angelo 1 Glazer, Robert I. 1 Felsted, Ronad L. 1; Affiliation:  1: Laboratory of Biological Chemistry, Division of Cancer Treatment, Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda; Source Info: 6/15/89, Vol. 182 Issue 2, p323; Subject Term: HIV (Viruses); Subject Term: PROTEINS; Subject Term: CELL lines; Subject Term: HYDROLYSIS; Subject Term: LIQUID chromatography; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaslow, Richard A.
AU  - Blackwelder, William C.
AU  - Ostrow, David G.
AU  - Yerg, Diane
AU  - Palenicek, John
AU  - Coulson, Anne H.
AU  - Valdiserri, Ronald O.
T1  - No Evidence for a Role of Alcohol or Other Psychoactive Drugs in Accelerating Immunodeficiency in HIV-1-Positive Individuals.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/06/16/
VL  - 261
IS  - 23
M3  - Article
SP  - 3424
EP  - 3429
SN  - 00987484
AB  - Describes the lack of evidence for a relationship between use of psychoactive drugs or alcohol and subsequent occurrence of AIDS or other manifestations of clinical and cellular immunodeficiency.  No manifestations of immunodeficiency positively associated with substance use; Inability of psychoactive drugs to enhance the progression of human immunodeficiency virus infection.
KW  - PSYCHIATRIC drugs
KW  - ALCOHOL
KW  - AIDS (Disease)
KW  - IMMUNODEFICIENCY
N1  - Accession Number: 10982641; Kaslow, Richard A. 1 Blackwelder, William C. 1 Ostrow, David G. 2,3 Yerg, Diane 1 Palenicek, John 4 Coulson, Anne H. 5 Valdiserri, Ronald O. 6; Affiliation:  1: National Institute of Allergy and Infectious Diseases, National Institutes of Health  2: Howard Brown Memorial Clinic and Northwestern University  3: Department of Psychiatry and Institute for Social Research, University of Michigan  4: The Johns Hopkins University School of Hygiene and Public Health  5: University of California School of Public Health and Medicine  6: University of Pittsburgh (Pa) Graduate School of Public Health; Source Info: 6/16/89, Vol. 261 Issue 23, p3424; Subject Term: PSYCHIATRIC drugs; Subject Term: ALCOHOL; Subject Term: AIDS (Disease); Subject Term: IMMUNODEFICIENCY; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Lal, R. B.
AU  - Kumaraswami, V.
AU  - Krishnan, N.
AU  - Nutman, T. B.
AU  - Ottesen, E. A.
T1  - Lymphocyte subpopulations in Bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1989/07//
VL  - 77
IS  - 1
M3  - Article
SP  - 77
EP  - 82
PB  - Wiley-Blackwell
SN  - 00099104
AB  - To examine the relationship between lymphocyte phenotypes and stales or activation in patients with Bancroftian filariasis, dual colour flow cytometry and concurrent in vitro cell culture were performed on normal individuals (NV; n= 15), and on patients with cither asymptomatic microfilaraemia (MF; n = 12) or elephantiasis (CP: n =11). In contrast to findings by others in a population with Brugian filariasis, the percentages of total B lymphocytes (CD19), T lymphocytes (CD3), helper/inducer T lymphocytes (CD4), and suppressor/cytotoxic T lymphocytes (CD8) in both patient groups were found lo be within the range defined by clinically normal individuals. Furthermore, there were no differences among the groups in the expression of the IL-2 receptor (CD25) on T cells. There was, however, a significantly greater proportion (P < 0.01) of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 ± 8.6%) than in the MF (8.9 ± 2.6%) or NV (8.3 ± 2.9%) groups. Further, when the expression of this activation antigen was examined in parallel with in vitro mitogen responsiveness, an inverse correlation between the percentage of CD8+ HLA-DR+ lymphocytes and pokeweed mitogen induced proliferation was seen ( r =  -0.54; P < 0.001). These data provide further definition of the immunoregulatory abnormalities seen in human filarial infections and suggest that activated CD8+ T lymphocytes may be involved in the pathogenesis of the chronic obstructed lymphatic form of this disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - CELL populations
KW  - LYMPHOCYTES
KW  - FILARIASIS
KW  - HELMINTHIASIS
KW  - PHENOTYPE
KW  - CELL culture
KW  - CD8 lymphocytes
KW  - Lymphatic filariasis
KW  - lymphocyte phenotype
N1  - Accession Number: 16137232; Lal, R. B. 1 Kumaraswami, V. 2 Krishnan, N. 2 Nutman, T. B. 1 Ottesen, E. A. 1; Affiliation:  1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.  2: Tuberculosis Research Center, Madras, India.; Source Info: Jul1989, Vol. 77 Issue 1, p77; Subject Term: INTERLEUKIN-2; Subject Term: CELL populations; Subject Term: LYMPHOCYTES; Subject Term: FILARIASIS; Subject Term: HELMINTHIASIS; Subject Term: PHENOTYPE; Subject Term: CELL culture; Author-Supplied Keyword: CD8 lymphocytes; Author-Supplied Keyword: Lymphatic filariasis; Author-Supplied Keyword: lymphocyte phenotype; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hirose, S.
AU  - Singh, V. K.
AU  - Donoso, L. A.
AU  - Shinohara, T.
AU  - Kotake, S.
AU  - Tanaka, T.
AU  - Kuwabara, T.
AU  - Yamaki, K.
AU  - Gery, I.
AU  - Nussenblatt, R. B.
T1  - An 18-mer peptide derived from the retinal S antigen induces uveitis and pinealitis in primates.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1989/07//
VL  - 77
IS  - 1
M3  - Article
SP  - 106
EP  - 111
PB  - Wiley-Blackwell
SN  - 00099104
AB  - S-antigen, a photoreceptor cell protein, induces a predominantly T-cell mediated autoimmune uveitis in many vertebrate animals, including primates. Because of this activity and the finding of immune responses to S antigen in patients with uveilis, this protein has been implicated In the pathogenesis of uveitis in humans, Peptide M, an 18-amino acid component of S antigen, has previously been shown to be highly uveito pathogenic in rats and guinea pigs. We report here that peptide M is immunopathogenic in some monkeys, producing inflammatory changes in eyes and pineal glands similar to those induced by native S antigen. Monkeys with disease also developed intense immune responses to peptide M, measured by the lymphocyte proliferation assay. In addition, lymphocytes from these monkeys reacted against whole S antigen. Furthermore, lymphocytes from certain monkeys immunized with whole S antigen responded well against peptide M, thus indicating that this peptide is an immunodominant epitope in these animals. Two of the four monkeys immunized with peptide M did not develop disease. Lymphocytes from these two animals did not respond In culture against the peptide. Following immunization with the whole protein, these monkeys were capable. however, of developing cellular immunity against S antigen and one of them developed disease. The possible involvement of peptide M in the pathogenesis of uveitis in humans is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - UVEITIS
KW  - EYE -- Inflammation
KW  - PEPTIDES
KW  - AMINO acids
KW  - INFLAMMATION -- Mediators
KW  - PINEAL gland
KW  - IMMUNE response -- Molecular aspects
KW  - lymphocyte proliferation
KW  - pinealitis
KW  - primates
KW  - S antigen
KW  - uveitis
N1  - Accession Number: 16137239; Hirose, S. 1 Singh, V. K. 1 Donoso, L. A. 2 Shinohara, T. 1 Kotake, S. 1 Tanaka, T. 1 Kuwabara, T. 3 Yamaki, K. 1 Gery, I. 1 Nussenblatt, R. B. 1; Affiliation:  1: Laboratories of Immunology, National Institutes of Health, Bethesda, MD.  2: Wills Eye Hospital, Philadelphia, PA.  3: Ophthalmic Pathology, National Eye Institute, National Institutes of Health, Bethesda, MD.; Source Info: Jul1989, Vol. 77 Issue 1, p106; Subject Term: UVEITIS; Subject Term: EYE -- Inflammation; Subject Term: PEPTIDES; Subject Term: AMINO acids; Subject Term: INFLAMMATION -- Mediators; Subject Term: PINEAL gland; Subject Term: IMMUNE response -- Molecular aspects; Author-Supplied Keyword: lymphocyte proliferation; Author-Supplied Keyword: pinealitis; Author-Supplied Keyword: primates; Author-Supplied Keyword: S antigen; Author-Supplied Keyword: uveitis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - van den Hoogen, Yvonne Th.
AU  - Hilgersom, Coen M.A.
AU  - Brozda, Danuta
AU  - Lesiak, Krystyna
AU  - Torrence, Paul F.
AU  - Altona, Cornelis
T1  - Conformational analysis of brominated pA2'-5'A2'-5'A analogs.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/07//7/1/89
VL  - 182
IS  - 3
M3  - Article
SP  - 629
EP  - 637
PB  - Wiley-Blackwell
SN  - 00142956
AB  - NMR and model-building studies were carried out on pA2'-5'A2'-5'A and analogs in which one or more of the A residues were replaced by 8-bromoadenosine. Chemical shifts, coupling constants and NOE data were used to obtain structural information. The N/S equilibrium constant of the ribose rings as well as the phase angles and puckering amplitudes were determined from the experimental coupling constants with the aid of an improved version of the PSEUROT program. Chemical shifts in combination with NOE data were used to monitor base-base interactions and the orientation of the bases (syn or anti). The combined data suggest that different types of stacking interactions are present in the various compounds. Bromination of the first or second residue in the trimers results in a preference for N-type sugar and syn orientation of the base in these residues. When A(3) is brominated, an S-type sugar conformation together with a syn orientation of the base is favoured at the 2' terminus. Energy-minimized models of the different stacking interactions are presented which fit the present collection of data. The possible correlation between biological activity of these compounds and their conformation is briefly discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADENOSINE
KW  - NUCLEAR magnetic resonance
KW  - RIBOSE
KW  - EQUILIBRIUM
KW  - BROMINATION
KW  - BIOCHEMISTRY
N1  - Accession Number: 13923309; van den Hoogen, Yvonne Th. 1 Hilgersom, Coen M.A. 1 Brozda, Danuta 2 Lesiak, Krystyna 2 Torrence, Paul F. 2 Altona, Cornelis 1; Affiliation:  1: Gorlaeus Laboratories, Leiden University  2: Section on Biomedical Chemistry, Laboratory of Analytical Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD; Source Info: 7/1/89, Vol. 182 Issue 3, p629; Subject Term: ADENOSINE; Subject Term: NUCLEAR magnetic resonance; Subject Term: RIBOSE; Subject Term: EQUILIBRIUM; Subject Term: BROMINATION; Subject Term: BIOCHEMISTRY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Khan, Wasiuddin A.
AU  - Park, Sang S.
AU  - Gelboin, Harry V.
AU  - Bickers, David R.
AU  - Mukhtar, Hasan
T1  - Monoclonal Antibodies Directed Characterization of Epidermal and Hepatic Cytochrome P-450 Isozymes Induced by Skin Application of Therapeutic Crude Coal Tar.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/07//
VL  - 93
IS  - 1
M3  - Article
SP  - 40
EP  - 45
SN  - 0022202X
AB  - A single application of crude coal tar (CCT) solution (USP) to the skin of neonatal rats was shown to induce epidermal and hepatic cytochrome P-450(P-450)-dependent monooxygenase activities. To further characterize the induction response, in this study we have utilized highly specific monoclonal antibodies (MoAb) 1-7-1, 2-66-3, and 1-98-1 directed against highly purified rat liver P-450s induced by 3-methylcholanthrene, phenobarbital and ethanol, respectively. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of hepatic microsomes prepared from CCT-treated animals showed a significant increase in the commassie blue stainable proteins in the P-450 region; however, this was not evident in epidermal microsomes. Immunoblot analysis of epidermal and hepatic microsomes with MoAb 1-7-1 revealed strong immunoprecipitin brands in both tissues. MoAb 2-66-3 showed significant immunoreactivity only with hepatic microsomes. Interestingly, CCT treatment resulted in suppression of immunoreactivity with MoAb 1-98-1 in hepatic microsomes. MoAb 1-7-1 and 2-66-3 exhibited concentration-dependent inhibitory effects in aryl hydrocarbon hydroxylase and 7-ethoxycoumarin-O-deethylase activities induced by CCT application. MoAb 1-7-1 was substantially more effective in this respect. Epidermal and hepatic mocrosomes prepared from CCT-treated rats showed significantly greater metabolism of benzo(a)pyrene (BP). MoAb 1-7-1 and MoAb 2-66-3 inhibited BP metabolism in both the tissues. However, MoAb 1-7-1 was more inhibitory in this regard as compared to MoAb2-66-3. These studies indicate that topical application of therapeutic CCT to the skin of neonatal rats results in induction of P-450 isozyme c in epidermis and isozymes b and c in liver, and that this induction is associated with the suppression of P-450 isozyme J in liver. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - CYTOCHROMES
KW  - EPIDERMIS
KW  - OXYGENASES
KW  - ISOENZYMES
KW  - GEL electrophoresis
N1  - Accession Number: 12277342; Khan, Wasiuddin A. 1 Park, Sang S. 2 Gelboin, Harry V. 2 Bickers, David R. 1 Mukhtar, Hasan 1; Affiliation:  1: Department of Dermatology, University Hospital of Cleveland, Case Western Reserve University and Veterans Administration Medical Center, Cleveland, Ohio  2: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul89, Vol. 93 Issue 1, p40; Subject Term: MONOCLONAL antibodies; Subject Term: CYTOCHROMES; Subject Term: EPIDERMIS; Subject Term: OXYGENASES; Subject Term: ISOENZYMES; Subject Term: GEL electrophoresis; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277342
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jetten, Anton M.
AU  - George, Margaret A.
AU  - Pettit, George R.
AU  - Herald, Cherry L.
AU  - Rearick, James I.
T1  - Action of Phorbol Esters, Bryostatins, and Retinoic Acid on Cholesterol Sulfate Synthesis: Relation to the Multistep Process of Differentiation in Human Epidermal Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/07//
VL  - 93
IS  - 1
M3  - Article
SP  - 108
EP  - 115
SN  - 0022202X
AB  - This study examines the action of phorbol 12-myristate 13-acetate (PMA) on the synthesis of cholesterol sulfate in cultured normal and transformed human epidermal keratinocytes and assesses the antagonistic effects by retinoids and bryostatins on PMA action in relation to the multistep program of squamous differentiation. Treatment of normal human epidermal keratinocytes (NHEK) with PMA induces terminal cell division (irreversible growth-arrest) and causes a time- and dose-dependent increase in the incorporation of Na235SO4 into cholesterol sulfate, a marker for squamous cell differentiation. This stimulation in sulfate incorporation appears specific for cholesterol sulfate and is due to increased levels of cholesterol sulfotransferase activity. The increase in cholesterol sulfate accumulation parallels the increase in transglutaminase type I, another marker for squamous differentiation. Several transformed NHEK cell lines do not exhibit increased levels of cholesterol sulfate and transglutaminase type I activity after PMA treatment, indicating that they acquired defects in the regulation of squamous differentiation. Bryostatins 1 and 2, and several diacylglycerol analogues neither inhibit cell proliferation nor increase cholesterol sulfate synthesis or transglutaminase activity, indicating that these agents do not induce terminal differentiation. In contrast, the bryostatins block the increase in cholesterol sulfate and transglutaminase activity as well as the commitment to terminal cell division by PMA. Bryostatin 1 inhibits the commitment to terminal cell division and the accumulation of cholesterol sulfate significantly even when added 8 h after PMA administration. Retinoids inhibit cholesterol sulfate accumulation and the increase in transglutaminase activity by PMA but do not affect the commitment to terminal cell division. In summary, phorbol esters induce in NHEK cells a program of squamous differentiation. This process of differentiation consists of the commitment to terminal cell division and expression of the squamous phenotype. Expression of this phenotype is accompanied by an accumulation of cholesterol sulfate and increased cholesterol sulfotransferase activity. Bryostatins 1 and 2 and retinoic acid affect this differentiation process at different stages. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHORBOL esters
KW  - TRETINOIN
KW  - CHOLESTEROL
KW  - KERATINOCYTES
KW  - EPIDERMIS
KW  - CELL differentiation
N1  - Accession Number: 12277374; Jetten, Anton M. 1 George, Margaret A. 1 Pettit, George R. 2 Herald, Cherry L. 2 Rearick, James I. 3; Affiliation:  1: Cell Biology Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina  2: Cancer Research Institute and Department of Chemistry, Arizona State University, Temple, Arizona  3: Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, Missouri, U.S.A.; Source Info: Jul89, Vol. 93 Issue 1, p108; Subject Term: PHORBOL esters; Subject Term: TRETINOIN; Subject Term: CHOLESTEROL; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: CELL differentiation; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277374
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104754238
T1  - HIV and HTLV-I infections in the Americas: a regional perspective.
AU  - Quinn, T C
AU  - Zacarias, F R
AU  - St John, R K
Y1  - 1989/07//1989 Jul
N1  - Accession Number: 104754238. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Acquired Immunodeficiency Syndrome -- Epidemiology
KW  - RNA Virus Infections -- Epidemiology
KW  - Acquired Immunodeficiency Syndrome -- Complications
KW  - Acquired Immunodeficiency Syndrome -- Transmission
KW  - Central America
KW  - RNA Virus Infections -- Complications
KW  - RNA Virus Infections -- Transmission
KW  - Health
KW  - North America
KW  - Population Surveillance
KW  - Preventive Health Care
KW  - Retrovirus Infections -- Epidemiology
KW  - South America
SP  - 189
EP  - 209
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 68
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - With over 143,000 cases of AIDS reported to the World Health Organization from 145 countries and with an estimated 5 to 10 million people worldwide infected with HIV, AIDS has become firmly established as a global pandemic. In the region of the Americas over 100,862 cases of AIDS have been reported with indigenous transmission documented in 45 to 46 countries. While North America has the highest annual number of AIDS cases per population, with 72 cases/million, the Caribbean subregion has a disproportionately high number of cases, with annual rates as high as 200 to 300 cases/million population for some countries. Despite differences in absolute number of cases, there has been a remarkable similarity in the temporal rate of increase of AIDS in the countries of the Americas, reflecting delayed introduction of the virus to some areas with an early exponential increase similar to that observed initially in the United States. Although the modes of transmission of HIV are the same throughout the region, evidence of increasing bisexual and heterosexual transmission, particularly in the Caribbean subregion, has resulted in a lower male-to-female ratio of AIDS cases and increased perinatal transmission. Clinically, a resurgence of diarrheal diseases, respiratory infections, and tuberculosis has been documented in association with HIV infection in many tropical countries of the Americas. With relatively high rates of HTLV-I infection already established in the Caribbean subregion, the overall public health problems of the Americas will be markedly potentiated by further spread of these 2 human retroviruses. If HIV infection continues to penetrate the poor and less advantaged populations in Latin America and the Caribbean, the potential exists for a massive epidemic in the Americas that may rapidly parallel the situation in Africa.
SN  - 0025-7974
AD  - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
U2  - PMID: 2544782.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Interferon Alfa May Suppress Chronic Infection by AIDS Virus.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/07/
VL  - 262
IS  - 1
M3  - Article
SP  - 17
EP  - 17
SN  - 00987484
AB  - Reports on the study finding that interferon alfa may suppress expression of human immunodeficiency virus type 1 (HIV-1) in chronically infected promonocytes and T-lymphocytes.  Study by Anthony Fauci and Guido Poli of the National Institute of Allergy and Infectious Diseases and colleagues.
KW  - INTERFERONS
KW  - HIV (Viruses)
KW  - T cells
KW  - FAUCI, Anthony S., 1940-
KW  - POLI, Guido
N1  - Accession Number: 10981808; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: INTERFERONS; Subject Term: HIV (Viruses); Subject Term: T cells; People: FAUCI, Anthony S., 1940-; People: POLI, Guido; Number of Pages: 1/6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Some Genetic Factors in Colorectal Carcinomas Identified.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/07/
VL  - 262
IS  - 1
M3  - Article
SP  - 17
EP  - 17
SN  - 00987484
AB  - Reports on researchers' identification of genetic events underlying tumorigenesis in colorectal carcinomas.  Study by Bert Vogelstein and colleagues; Finding that allelic deletions were common; Potential for improving assessment of prognosis; Related study with finding that chromosome 17 deletions and p53 genetic mutations may be involved in colorectal neoplasia.
KW  - COLON cancer
KW  - CARCINOGENESIS
KW  - MEDICAL genetics
KW  - VOGELSTEIN, Bert, 1949-
N1  - Accession Number: 10981809; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: COLON cancer; Subject Term: CARCINOGENESIS; Subject Term: MEDICAL genetics; People: VOGELSTEIN, Bert, 1949-; Number of Pages: 1/3p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Information on AIDS Trials Available.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/07/
VL  - 262
IS  - 1
M3  - Article
SP  - 17
EP  - 17
SN  - 00987484
AB  - Reports on the establishment of an AIDS Clinical Trials Information Service by the National Institutes of Allergy and Infectious Diseases, in cooperation with the Centers for Disease Control.  Provision and updating of information about National Institutes of Health (NIH)-sponsored trials of experimental therapies for patients with AIDS and AIDS-related diseases.
KW  - AIDS (Disease)
KW  - CLINICAL trials
KW  - INFORMATION services
KW  - NATIONAL Institute of Allergy & Infectious Diseases (U.S.)
KW  - CENTERS for Disease Control & Prevention (U.S.)
N1  - Accession Number: 10981810; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: AIDS (Disease); Subject Term: CLINICAL trials; Subject Term: INFORMATION services; Company/Entity: NATIONAL Institute of Allergy & Infectious Diseases (U.S.) Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 1/9p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Dipyridamole May Enhance Effectiveness of AIDS Therapy.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/07/
VL  - 262
IS  - 1
M3  - Article
SP  - 17
EP  - 17
SN  - 00987484
AB  - Reports on an in vitro study demonstrating that the platelet antiaggregant and coronary vasodilator dipyridamole (Persantine) potentiates the anti-HIV effects of zidovudine (AZT) and of dideoxycytidine in human monocyte/macrophages.  Findings of scientists at the National Cancer Institute, the National Institutes of Dental Research and their associates.
KW  - VASODILATORS
KW  - AZT (Drug)
KW  - AIDS (Disease) -- Treatment
KW  - DRUG synergism
KW  - MACROPHAGES
N1  - Accession Number: 10981811; Wyngaarden, James B. 1; Affiliation:  1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: VASODILATORS; Subject Term: AZT (Drug); Subject Term: AIDS (Disease) -- Treatment; Subject Term: DRUG synergism; Subject Term: MACROPHAGES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sempos, Christopher
AU  - Fulwood, Robinson
AU  - Haines, Carol
AU  - Carroll, Margaret
AU  - Anda, Robert
AU  - Williamson, David F.
AU  - Remington, Patrick
AU  - Cleeman, James
T1  - The Prevalence of High Blood Cholesterol Levels Among Adults in the United States.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/07/
VL  - 262
IS  - 1
M3  - Article
SP  - 45
EP  - 52
SN  - 00987484
AB  - Estimates the prevalence of high blood cholesterol levels among adults in the U.S.  Use of the National Cholesterol Education Program's Guidelines for the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults and the serum total cholesterol and lipopoprotein date from the second National Health and Nutrition Examination Survey.
KW  - BLOOD cholesterol
KW  - PUBLIC health
KW  - BLOOD lipoproteins
KW  - HEALTH surveys
KW  - UNITED States
N1  - Accession Number: 10981814; Sempos, Christopher 1 Fulwood, Robinson 2 Haines, Carol 2 Carroll, Margaret 1 Anda, Robert 3 Williamson, David F. 3 Remington, Patrick 3,4 Cleeman, James 2; Affiliation:  1: National Center for Health Statistics, Centers for Disease Control  2: National Heart, Lung, and Blood Institute, National Institutes of Health  3: Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control  4: Bureau of Community Health and Prevention, Wisconsin Division of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p45; Subject Term: BLOOD cholesterol; Subject Term: PUBLIC health; Subject Term: BLOOD lipoproteins; Subject Term: HEALTH surveys; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wyngaarden, James B.
T1  - Information on AIDS Trials Available.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/07/
VL  - 262
IS  - 1
M3  - Article
SP  - 17
EP  - 17
SN  - 00987484
AB  - Reports on the establishment of an AIDS Clinical Trials Information Service by the National Institutes of Allergy and Infectious Diseases, in cooperation with the Centers for Disease Control.  Provision and updating of information about National Institutes of Health (NIH)-sponsored trials of experimental therapies for patients with AIDS and AIDS-related diseases.
KW  - AIDS (Disease)
KW  - CLINICAL trials
KW  - INFORMATION services
KW  - NATIONAL Institute of Allergy & Infectious Diseases (U.S.)
KW  - CENTERS for Disease Control & Prevention (U.S.)
N1  - Accession Number: 10981810; Wyngaarden, James B. 1; Source Information: 7/7/89, Vol. 262 Issue 1, p17; Subject: AIDS (Disease); Subject: CLINICAL trials; Subject: INFORMATION services; Subject: NATIONAL Institute of Allergy & Infectious Diseases (U.S.); Subject: CENTERS for Disease Control & Prevention (U.S.); Number of Pages: 1/9p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Haverkos, Harry W.
AU  - Bukoski Jr., William J.
AU  - Amsel, Zili
AU  - Haverkos, H W
AU  - Bukoski, W J Jr
AU  - Amsel, Z
T1  - The initiation of male homosexual behavior.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/28/
VL  - 262
IS  - 4
M3  - letter
SP  - 501
EP  - 501
SN  - 00987484
AB  - Presents a letter to the editor reporting on the initiation of homosexuality intercourse, based on the data collected by the U.S. Centers for Disease Control, published in the 'Journal of American Medical Association'.
KW  - LETTERS to the editor
KW  - HOMOSEXUALITY
KW  - AIDS (Disease) -- Prevention
KW  - AGE distribution (Demography)
KW  - HUMAN sexuality
KW  - SEX education
N1  - Accession Number: 10975802; Haverkos, Harry W. 1 Bukoski Jr., William J. Amsel, Zili Haverkos, H W Bukoski, W J Jr Amsel, Z; Affiliation:  1: National Institute on Drug Abuse, Rockville, Md.; Source Info: 7/28/89, Vol. 262 Issue 4, p501; Subject Term: LETTERS to the editor; Subject Term: HOMOSEXUALITY; Subject Term: AIDS (Disease) -- Prevention; Subject Term: AGE distribution (Demography); Subject Term: HUMAN sexuality; Subject Term: SEX education; Number of Pages: 1p; Illustrations: 1 Graph; Document Type: letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kiebanoff, Mark A.
AU  - Shiono, Patricia H.
AU  - Berendes, Heinz W.
AU  - Rhoads, George G.
T1  - Facts and Artifacts About Anemia and Preterm Delivery.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/28/
VL  - 262
IS  - 4
M3  - Article
SP  - 511
EP  - 515
SN  - 00987484
AB  - Examines the effects of maternal anemia on the pathogenesis of preterm birth.  Incidence of preterm birth among women with and without anemia; Dose-response effect for anemia; Comparison of hematocrits from women who are in preterm and term labor.
KW  - ANEMIA
KW  - PREMATURE labor
KW  - HEMATOCRIT
KW  - UNITED States
N1  - Accession Number: 10975839; Kiebanoff, Mark A. 1 Shiono, Patricia H. 1 Berendes, Heinz W. 1 Rhoads, George G. 1; Affiliation:  1: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.; Source Info: 7/28/89, Vol. 262 Issue 4, p511; Subject Term: ANEMIA; Subject Term: PREMATURE labor; Subject Term: HEMATOCRIT; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Maton, Paul N.
AU  - Norton, Jeffrey A.
AU  - Nieman, Lynnette K.
AU  - Doppman, John L.
AU  - Jensen, Robert T.
T1  - Multiple Endocrine Neoplasia Type II With Zollinger-Ellison Syndrome Caused by a Solitary Pancreatic Gastrinoma.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/28/
VL  - 262
IS  - 4
M3  - Article
SP  - 535
EP  - 537
SN  - 00987484
AB  - Reports on the cases of patients with multiple endocrine neoplasia (MEN) type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma.  Forms of MEN; Clinical manifestations and symptoms; Comparison with other related diseases; Treatment options.
KW  - ENDOCRINE glands -- Tumors
KW  - ZOLLINGER-Ellison syndrome
KW  - SYMPTOMS
N1  - Accession Number: 10975844; Maton, Paul N. 1 Norton, Jeffrey A. 2 Nieman, Lynnette K. 3 Doppman, John L. 4 Jensen, Robert T. 1; Affiliation:  1: Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda  2: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda  3: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda  4: Diagnostic Radiology, the Clinical Center, National Institutes of Health, Bethesda; Source Info: 7/28/89, Vol. 262 Issue 4, p535; Subject Term: ENDOCRINE glands -- Tumors; Subject Term: ZOLLINGER-Ellison syndrome; Subject Term: SYMPTOMS; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hallett, Mark
AU  - Cohen, Leonardo G.
T1  - Magnetism.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/07/28/
VL  - 262
IS  - 4
M3  - Article
SP  - 538
EP  - 541
SN  - 00987484
AB  - Describes a method for the stimulation of nerve and brain for the treatment of a patient who experienced transient numbness of both hands diagnosed as multiple sclerosis.  Signs and symptoms of multifocal disease in the central nervous system; Observation of the central motor pathways; Electric stimulation procedures; Magnetic stimulation; Treatment.
KW  - NEURAL stimulation
KW  - MULTIPLE sclerosis
KW  - NERVOUS system -- Diseases
N1  - Accession Number: 10975845; Hallett, Mark 1 Cohen, Leonardo G. 1; Affiliation:  1: Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda; Source Info: 7/28/89, Vol. 262 Issue 4, p538; Subject Term: NEURAL stimulation; Subject Term: MULTIPLE sclerosis; Subject Term: NERVOUS system -- Diseases; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hilakivi, L. A.
AU  - Lister, R. G.
T1  - Comparison Between BALB/cJ and BALB/cByJ Mice in Tests of Social Behavior and Resident-Intruder Aggression.
JO  - Aggressive Behavior
JF  - Aggressive Behavior
Y1  - 1989/08//
VL  - 15
IS  - 4
M3  - Article
SP  - 273
EP  - 280
PB  - John Wiley & Sons, Inc.
SN  - 0096140X
AB  - The behavior of male mice from two BALB strains, the BALB/cJ strain and the BALB/ cByJ strain, was examined with a social behavior test and a resident-intruder paradigm. Prior to testing, the animals were isolated for 0, 2, 5, or 10 days. In the social behavior test the pairs of BALB/cJ mice spent more time in active social interaction than pairs of BALB/cByJ mice, although the latter strain showed more locomotor activity. BALB/cJ mice isolated for 5-10 days, when tested in a familiar environment were more aggressive than mice from the BALB/cByJ strain. In the resident-intruder paradigm, in which a resident BALB mouse was confronted with an intruder NIH Swiss mouse, the BALB/cByJ mice showed more social investigation in their home rage Inwards the intruders, but there were no significant differences between the two strains in the amounts of aggressive behavior exhibited. The resells of these experiments suggest that there are some differences in the social behavior of the genetically related BALB/cJ and BALB/cByJ mice. However, the differences appear subtle and paradigm-specific. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Aggressive Behavior is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERPERSONAL relations
KW  - SOCIAL interaction
KW  - AGGRESSION (Psychology)
KW  - GENETICS
KW  - PERSONALITY
KW  - MICE as laboratory animals
KW  - aggression
KW  - genetics
KW  - isolation
KW  - mouse
N1  - Accession Number: 47683917; Hilakivi, L. A. 1 Lister, R. G. 1; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies, DICBR, Bethesda, Maryland; Source Info: 1989, Vol. 15 Issue 4, p273; Subject Term: INTERPERSONAL relations; Subject Term: SOCIAL interaction; Subject Term: AGGRESSION (Psychology); Subject Term: GENETICS; Subject Term: PERSONALITY; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: aggression; Author-Supplied Keyword: genetics; Author-Supplied Keyword: isolation; Author-Supplied Keyword: mouse; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morales, Pilar Garcia
AU  - Barriocanal, Javier G.
AU  - Sandoval, Ignacio V.
T1  - Reduced temperaturedoes not prevent transport of lysosomal integral membrane proteins from endoplasmic reticulum and through the Golgi system to lysosomes.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/08//8/1/89
VL  - 183
IS  - 2
M3  - Article
SP  - 407
EP  - 412
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The effect of low temperature on the transport of three lysosomal integral membrane proteins (I, II and III) from endoplasmic reticulum to lysosomes has been studied in normal rat kidney cells. At 15°C and 18°C, though slowly, the proteins could leave the endoplasmic reticulum, move through the Golgi system from the cis to the trans side, and accumulate in lysosomes. Transport of these proteins at low temperature occurred slower than at 37 °C. Both at low temperature and 37 °C, the proteins were transported between the endoplasmic reticulum and Golgi (III > I and II) and from Golgi to lysosomes (II > III > > I) with different rates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LOW temperatures
KW  - MEMBRANE proteins
KW  - ENDOPLASMIC reticulum
KW  - GOLGI apparatus
KW  - CELL organelles
KW  - LYSOSOMES
KW  - CYTOLOGY
N1  - Accession Number: 13728012; Morales, Pilar Garcia 1 Barriocanal, Javier G. 1 Sandoval, Ignacio V. 1; Affiliation:  1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda; Source Info: 8/1/89, Vol. 183 Issue 2, p407; Subject Term: LOW temperatures; Subject Term: MEMBRANE proteins; Subject Term: ENDOPLASMIC reticulum; Subject Term: GOLGI apparatus; Subject Term: CELL organelles; Subject Term: LYSOSOMES; Subject Term: CYTOLOGY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gammon, W. R.
AU  - Yancey, K. B.
AU  - Mangum, Karen L.
AU  - Hendrix, John D.
AU  - Hammer, C. H.
T1  - Generation of C5-Dependent Bioactivity by Tissue-Bound Anti-BMZ Autoantibodies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/08//
VL  - 93
IS  - 2
M3  - Article
SP  - 195
EP  - 200
SN  - 0022202X
AB  - We previously reported that complement-binding anti-basement membrane zone (BMZ) auto antibodies can mediate complement-dependent directed migration and adherence of leukocytes to the BMZ in cryostat skin sections and that there is heterogeneity in the ability of anti-BMZ auto antibodies to mediate that response. Those observations suggested that directed migration and adherence of leukocytes to the BMZ might be dependent on the amount of complement-activating autoantibody deposited at the BMZ and the extent to which those antibodies could activate complement and generate C5-derived peptides (C5a, C5a des arg). In this study, we have examined the role of autoantibody concentration and C5 in mediating the adherence response. When cryostat skin sections were pretreated with anti-BMZ auto antibodies and subsequently incubated with neutrophils suspended in fresh serum, neutrophils adhered to the BMZ. Adherence was anti-BMZ autoantibody specific and proportional to anti-BMZ autoantibody concentration. To determine the role of C5 in mediating adherence, neutrophils were suspended in increasing concentrations of: 1) fresh serum, 2) heat-inactivated serum, 3) serum pretreated with antihuman C5, 4) serum pretreated with antihuman IgG, 5) C5-depleted serum, 6) purified C5, and 7) C5-depleted serum reconstituted with increasing concentrations of purified C5. The suspensions were then incubated with autoantibody-treated skin sections. The results showed a dose-dependent requirement for fresh serum and for C5-depleted serum reconstituted with increasing doses of C5. Adherence could be detected with C5 concentrations less than 200 ng/ml, which correspond to a C5a/C5a des arg concentration of 10-8 -10-9 molar.  These results suggest that complement-dependent neutrophil adherence is a highly sensitive method for detecting and quantitating the abilty of tissue-deposited anti-BMZ autoantibodies to activate complement and generate C5-derived bioactive peptides, for estimating the amount of C-activating anti-BMZ autoantibody deposited at the BMZ in vivo, and for evaluating the potential role of C-activating anti-BMZ autoantibodies in the pathogenesis of lesions [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN -- Cancer
KW  - BASAL lamina
KW  - AUTOANTIBODIES
KW  - LEUCOCYTES
KW  - CRYOSTATS
KW  - SERUM
N1  - Accession Number: 12277570; Gammon, W. R. 1 Yancey, K. B. 2 Mangum, Karen L. 1,2 Hendrix, John D. 1 Hammer, C. H. 3; Affiliation:  1: Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, U.S.A.  2: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A.  3: Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug89, Vol. 93 Issue 2, p195; Subject Term: SKIN -- Cancer; Subject Term: BASAL lamina; Subject Term: AUTOANTIBODIES; Subject Term: LEUCOCYTES; Subject Term: CRYOSTATS; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12277570
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06500-013
AN  - 2006-06500-013
AU  - Kochanska, Grazyna
T1  - The Study of Empathy Comes of Age.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1989/08//
VL  - 34
IS  - 8
SP  - 742
EP  - 744
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06500-013. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kochanska, Grazyna; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Emotional Development; Empathy; Prosocial Behavior; Psychosocial Development. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Eisenberg, Nancy (Ed); Strayer, Janet (Ed). Empathy and its Development=New York: Cambridge University Press, 1987. 406 pp. $49.50; 1987. References Available: Y. Page Count: 3. Issue Publication Date: Aug, 1989. 
AB  - Reviews the book, Empathy and its Development edited by Nancy Eisenberg and Janet Strayer (1987). This book is yet another integrative book in the relatively recent, but quickly growing, field of prosocial behavior. Addressed to professionals and graduate students, this text is a comprehensive selection of chapters by competent researchers in the field. It is divided into four sections focused respectively on history and theory, development, current research issues, and methodology. In summary, we have gained a valuable publication. It contains both systematic reviews, and papers that pose new questions and outline new research directions. It is of great interest to scholars and practitioners in the field of social and emotional development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - empathy
KW  - emotional development
KW  - prosocial behavior
KW  - 1989
KW  - Emotional Development
KW  - Empathy
KW  - Prosocial Behavior
KW  - Psychosocial Development
KW  - 1989
U2  - Eisenberg, Nancy (Ed); Strayer, Janet (Ed). (1987); Empathy and its Development; New York: Cambridge University Press, 1987. 406 pp. $49.50; 0-521-32609-5.
DO  - 10.1037/030983
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Lawley, Thomas J.
AU  - Kubota, Yasuo
T1  - Induction of Morphologic Differentiation of Endothelial Cells in Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/08/15/Aug89 Supplement
VL  - 93
M3  - Article
SP  - 59S
EP  - 61S
SN  - 0022202X
AB  - Human endothelial cells when grown in cell culture assume a "cobblestone" morphology and do not form tubes or capillarylike structures. We have recently identified a culture substrate containing basement membrane-derived proteins that promotes morphologic differentiation of human umbilical vein and human dermal microvascular endothelial cells into capillarylike tubes. This differentiation is rapid, beginning within 1 h and is complete by 8-12 h. On electron microscopy these cells form a lumen, derived from remodeling of multiple cells and also by forming holes in the cytoplasm of individual cells. The endothelial cells no longer proliferate when cultured on this substrate known as matrigel, but can be induced to do so when cultured on fibronectin. We have also identified a critical molecular signal for endothelial cell differentiation induced by matrigel. Laminin, a prime constituent of matrigel, and to a lesser extent collagen IV appear to be key elements in the differentiation of endothelial cells induced by matrigel. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - ENDOTHELIUM
KW  - EPITHELIUM
KW  - CELL culture
KW  - CULTURES (Biology)
KW  - ELECTRON microscopy
N1  - Accession Number: 12581070; Lawley, Thomas J. 1 Kubota, Yasuo 2; Affiliation:  1: Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.  2: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug89 Supplement, Vol. 93, p59S; Subject Term: CELLS; Subject Term: ENDOTHELIUM; Subject Term: EPITHELIUM; Subject Term: CELL culture; Subject Term: CULTURES (Biology); Subject Term: ELECTRON microscopy; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12581070
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sporn, Michael B.
AU  - Roberts, Anita B.
T1  - Transforming Growth Factor-β: Multiple Actions and Potential Clinical Applications.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/08/18/
VL  - 262
IS  - 7
M3  - Article
SP  - 938
EP  - 941
SN  - 00987484
AB  - Cites the potential clinical applications of the transformation of growth factor-beta (TGF-beta).  Use of TGF-beta in common clinical conditions for which there are no adequate pharmacologic agents; Identification of TGF-beta in an assay; Enhancement of the growth of fibroblasts in soft agar.
KW  - TRANSFORMING growth factors-beta
KW  - BIOLOGICAL assay
KW  - FIBROBLASTS
KW  - AGAR
N1  - Accession Number: 10981965; Sporn, Michael B. 1 Roberts, Anita B. 1; Affiliation:  1: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Md.; Source Info: 8/18/89, Vol. 262 Issue 7, p938; Subject Term: TRANSFORMING growth factors-beta; Subject Term: BIOLOGICAL assay; Subject Term: FIBROBLASTS; Subject Term: AGAR; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 2 Black and White Photographs, 1 Diagram; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Malloy, Michael H.
AU  - Kleinman, Joel C.
AU  - Bakewell, Janice M.
AU  - Schramm, Wayne F.
AU  - Land, Garland H.
T1  - Maternal Smoking during Pregnancy: No Association with Congenital Malformations in Missouri 1980-83.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/09//
VL  - 79
IS  - 9
M3  - Article
SP  - 1243
EP  - 1246
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: Using a multisource birth defects registry developed by the Missouri Center for Health Statistics for the years 1980-83, we examined the relation between maternal smoking during pregnancy and the occurrence of congenital malformations. There were 288,067 live singleton births in this data set of which 10,223 had one or more congenital malformations. When adjusted for potential confounders the odds ratio for congenital malformations in the infants of women who smoked during pregnancy was not increased (odds ratio = 0.98, 95% confidence interval = 0.94 - 1.03). We examined the relation between smoking and groups of malformations using the International Classification of Diseases, 9th Revision, as well as analyzing for certain specific malformations within each group and found no increased risk for infants of smokers. (Am J Public Health 1989; 79:1243-1246). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HUMAN abnormalities
KW  - MEDICAL statistics
KW  - SMOKING
KW  - PREGNANCY
KW  - GENETIC disorders
KW  - PREGNANT women
KW  - NOSOLOGY
KW  - INFANTS
KW  - MISSOURI
N1  - Accession Number: 4685442; Malloy, Michael H. 1 Kleinman, Joel C. 2 Bakewell, Janice M. 3 Schramm, Wayne F. 3 Land, Garland H. 3; Affiliation:  1: Prevention Research Program, National Institute of Child Health and Human Development, Executive Plaza North, Rm 640, Bethesda, MD 20892  2: Division of Analysis, National Center for Health Statistics  3: Missouri Department of Health Jefferson City; Source Info: Sep89, Vol. 79 Issue 9, p1243; Subject Term: HUMAN abnormalities; Subject Term: MEDICAL statistics; Subject Term: SMOKING; Subject Term: PREGNANCY; Subject Term: GENETIC disorders; Subject Term: PREGNANT women; Subject Term: NOSOLOGY; Subject Term: INFANTS; Subject Term: MISSOURI; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kurinij, Nathlie
AU  - Shiono, Patricia H.
AU  - Ezrine, Sandi F.
AU  - Rhoads, Geprge G.
T1  - Does Maternal Employment Affect Breast-Feeding?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/09//
VL  - 79
IS  - 9
M3  - Article
SP  - 1247
EP  - 1250
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: A prospective survey of maternal employment and breast-feeding initiation and duration was conducted among 668 Black and 511 White women who delivered their first child in Washington, DC. Ninety-one percent of White women (n = 511) and 80 percent of Black women (n = 668) reported working during pregnancy. Black women who planned to return to work part time vs full time were more likely to breast-feed rather than formula-feed (adjusted odds ratio, 2.3; 95% confidence intervals (CI) = 1.4, 3.7). Using Cox regression, Black women who returned to work had a shorter duration of breast-feeding than those not returning to work (hazard ratio = 0.5 (CI = 0.3, 0.9)). Black and White women returning to professional occupations had a longer duration of breast-feeding compared to women returning to sales or technical positions (hazard ratio for Black women = 2.4 (CI = 1.4, 4.4); hazard ratio for White women = 1.6 (CI = 1.0, 2.5)). In addition, White women in professional occupations had a longer duration of breastfeeding than women in clerical positions (hazard ratio = 1.7 (CI = 1.1, 2.6)). Until employers in the United States develop a maternity policy which does not discourage breast-feeding, the recommended six months of breast-feeding will be difficult to achieve for most employed women. (Am J Public Health 1989; 79:1247-1250). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SURVEYS
KW  - WOMEN -- Employment
KW  - BREASTFEEDING (Humans)
KW  - AFRICAN American women
KW  - PREGNANCY
KW  - PROFESSIONAL employees
KW  - MOTHERHOOD
KW  - WASHINGTON (D.C.)
KW  - UNITED States
N1  - Accession Number: 4685492; Kurinij, Nathlie 1 Shiono, Patricia H. 2 Ezrine, Sandi F. 3 Rhoads, Geprge G. 2; Affiliation:  1: Clinical Vision Research Branch, National Eye Institute, NIH, Building 31, Room 6A49, Bethesda, MD 20892  2: Epidemiology Branch, Prevention Research Program, NICHD/NIH  3: Research Associate, Inc., Baltimore, MD; Source Info: Sep89, Vol. 79 Issue 9, p1247; Subject Term: SURVEYS; Subject Term: WOMEN -- Employment; Subject Term: BREASTFEEDING (Humans); Subject Term: AFRICAN American women; Subject Term: PREGNANCY; Subject Term: PROFESSIONAL employees; Subject Term: MOTHERHOOD; Subject Term: WASHINGTON (D.C.); Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chan, C. C.
AU  - Ottesen, E. A.
AU  - Awadzi, K.
AU  - Badu, R.
AU  - Nussenblatte, R. B.
T1  - Immunopathology of ocular onchocerciasis. I. Inflammatory cells infilitrating the anterior segment.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1989/09//
VL  - 77
IS  - 3
M3  - Article
SP  - 367
EP  - 372
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Ocular tissue (conjunctiva and iris) was obtained from 12 adult African men with active ocular onchocerciasis and from nine age-matched persons from the same endemic region but without onchocercal infection. These tissues were examined immunohistologically and two major findings were noted. First, mild-to-moderate chronic inflammatory cellular infiltration was present in the conjunctiva of the onchocerciasis patients. T lymphocytes (CD3+) were the major inflammatory cells, and the T suppressor/cytotoxic (CD8+) subset was significantly increased in the ocular onchocerciasis patients (P < 0.03). Second, in the onchocerciasis patients, non-lymphoid cells of the conjunctiva and iris, such as vascular endothelium, pericytes and fibroblasts were in an activated slate, as shown by increased expression of Class M MHC antigens (P < 0.02, conjunctiva; P < 0.05, iris). These concomitant findings of lymphocyte infiltration and resident ceil activation indicate a dynamic state of localized host responsiveness presumably to the microfilarial parasites and their products in the anterior segments of the eyes of patients with ocular onchocerciasis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FILARIASIS
KW  - ONCHOCERCIASIS
KW  - CONJUNCTIVA
KW  - PRESERVATION of organs, tissues, etc.
KW  - ENDOTHELIUM
KW  - LEUCOCYTES
KW  - onchocerciasis conjunctiva iris immunopathology ocular inflammation
N1  - Accession Number: 15987682; Chan, C. C. 1 Ottesen, E. A. 2 Awadzi, K. 3 Badu, R. 3 Nussenblatte, R. B. 1; Affiliation:  1: National Eye Institute, Bethesda, MD, USA.  2: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.  3: Onchocerciasis Chemotherapeutic Research Centre, Tamale, Ghana.; Source Info: Sep1989, Vol. 77 Issue 3, p367; Subject Term: FILARIASIS; Subject Term: ONCHOCERCIASIS; Subject Term: CONJUNCTIVA; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: ENDOTHELIUM; Subject Term: LEUCOCYTES; Author-Supplied Keyword: onchocerciasis conjunctiva iris immunopathology ocular inflammation; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Larsen, C. G.
AU  - Anderson, A. O.
AU  - Oppenheim, J. J.
AU  - Matsushima, K.
T1  - Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor.
JO  - Immunology
JF  - Immunology
Y1  - 1989/09//
VL  - 68
IS  - 1
M3  - Article
SP  - 31
EP  - 36
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Cultured normal human fibroblasts were stimulated to produce neutrophil-activating protein/interleukin-8 (IL-8) in response to IL-1α (0.1-1000 U/ml) or turnout necrosis factor (TNF) α (0.1-1000 U/ml). Induction of mRNA for IL-8 in fibroblasts was rapid (within 30 min) and maximal responses were obtained with either 100 U/ml IL-1α or 100 U/ml TNFα. Expression of mRNA for IL- 8 was accompanied by the production of high levels of neutrophil chemotactic activity. IL-1α (1000 U/ml), but not TNFα, induced mRNA for IL-8 in cultured normal human keratinocytes. The relevance of production of IL-8 by these cell types was evaluated further by comparing the local inflammatory effects of IL-1α, TNFα and IL-8. Intradermal injection of either recombinant IL-8, IL-1α or TNFα lead to a similar in vivo effect, i.e. dose-dependent accumulation of lymphocytes and polymorphonuclear leucocytes at sites of injection. The in vivo attraction of neutrophils and lymphocytes to the site of injection by TNF or IL-1 (which is not chemotactic for neutrophils or lymphocytes in vitro), may be partly mediated by locally produced IL-8. Thus, IL-8 may be a vital participant in the cascade of interacting cytokines that is induced by tissue injury and immunologically induced inflammation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FIBROBLASTS
KW  - INTERLEUKIN-8
KW  - KERATINOCYTES
KW  - DERMIS
KW  - INTERLEUKIN-1
KW  - TUMOR necrosis factor
N1  - Accession Number: 13357276; Larsen, C. G. 1 Anderson, A. O. 1 Oppenheim, J. J. 2 Matsushima, K. 1; Affiliation:  1: Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute  2: Laboratory of Respiratory and Mucosal Immunity, Disease Assessment Division, USAM RIID, Fort Detrick, Frederick, Maryland, U.S.A.; Source Info: Sep89, Vol. 68 Issue 1, p31; Subject Term: FIBROBLASTS; Subject Term: INTERLEUKIN-8; Subject Term: KERATINOCYTES; Subject Term: DERMIS; Subject Term: INTERLEUKIN-1; Subject Term: TUMOR necrosis factor; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kirshenbaum, A. S.
AU  - Goff, J. P.
AU  - Metcalfe, D. D.
T1  - Human macrophages cultured on agar but not agarose resemble mast cells.
JO  - Immunology
JF  - Immunology
Y1  - 1989/09//
VL  - 68
IS  - 1
M3  - Article
SP  - 120
EP  - 125
PB  - Wiley-Blackwell
SN  - 00192805
AB  - It has been reported that rare colonies of mast cells may be identified when human bone marrow cells are cultured in agar. Based on this observation, we attempted to culture mast cells from human bone marrow using a modified agar interphase culture. Metachromatically staining cells appearing in culture peaked in number by 2-3 weeks and consisted of basophil-like cells, mast-like cells and larger, granulated cells superficially resembling mast cells. The large cells, which constituted the majority of metachromatic cells, were berberine sulphate-positive but negative for histamine, chloroacetate esterase, and mast cell tryptase. These larger granulated cells were subsequently identified as macrophages by FACS analysis with Leu M3 and by electron microscopy. Berberine sulphatestaining of macrophages was not due to the de novo synthesis of heparin, as shown by analysis of radiolabelled proteoglycans from cultured cells. The macrophage metachromasia was eliminated with the use of agarose. The metachromatic and berberine sulphate-staining of cultured human macrophages was therefore considered to be due to phagocytosed altar. Recognition of this phenomenon will aid in the proper identification of human mast cells and basophils in cultures where agar or similar substances are present, and demonstrates that berberbine sulphate-staining is not specific for heparin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MACROPHAGES
KW  - MAST cells
KW  - BONE marrow cells
KW  - HUMAN cell culture
KW  - CELL culture
KW  - BERBERINE
N1  - Accession Number: 13357385; Kirshenbaum, A. S. 1 Goff, J. P. 2 Metcalfe, D. D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda  2: Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland, U.S.A.; Source Info: Sep89, Vol. 68 Issue 1, p120; Subject Term: MACROPHAGES; Subject Term: MAST cells; Subject Term: BONE marrow cells; Subject Term: HUMAN cell culture; Subject Term: CELL culture; Subject Term: BERBERINE; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - No Increased Risk for Children Conceived In Vitro.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09//9/1/89
VL  - 262
IS  - 9
M3  - Article
SP  - 1158
EP  - 1158
SN  - 00987484
AB  - Reports that children conceived by in vitro fertilization are at no greater risk of congenital malformation or developmental dysfunction than other children.  Results of a study conducted by the Eastern Virginia Medical School; Score on the Mental and Psychomotor Development indexes of the Bayley Scales.
KW  - FERTILIZATION in vitro
KW  - GENETIC disorders
KW  - CHILDREN with disabilities
N1  - Accession Number: 11019505; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 9/1/89, Vol. 262 Issue 9, p1158; Subject Term: FERTILIZATION in vitro; Subject Term: GENETIC disorders; Subject Term: CHILDREN with disabilities; NAICS/Industry Codes: 325413 In-Vitro Diagnostic Substance Manufacturing; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - T-Cell Receptor Gene May Influence Susceptibility to Multiple Sclerosis (MS):.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09//9/1/89
VL  - 262
IS  - 9
M3  - Article
SP  - 1158
EP  - 1158
SN  - 00987484
AB  - Reports that researchers have found that a gene within the T-cell receptor (TCR) beta-chain complex influences susceptibility to multiple sclerosis (MS).  Analysis of the TCR-beta genotypes of 51 families in which one to three members were affected with the relapsing-remitting form of MS; Determination of the TCR-beta haploytpes by segregation analysis.
KW  - MULTIPLE sclerosis -- Genetic aspects
KW  - T cell receptors
N1  - Accession Number: 11019506; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 9/1/89, Vol. 262 Issue 9, p1158; Subject Term: MULTIPLE sclerosis -- Genetic aspects; Subject Term: T cell receptors; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Association Found Between Macular Degeneration and Lens Opacities:.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09//9/1/89
VL  - 262
IS  - 9
M3  - Article
SP  - 1158
EP  - 1158
SN  - 00987484
AB  - Reports that patients with lens opacities are at increased risk of having age-related macular degeneration (AMD).  Comparison with the prevalence of AMD in subjects with no lens opacities; Support for the implantation of ultraviolet- and blue-light-absorbing intraocular lenses following removal.
KW  - RETINAL degeneration
KW  - OPACITY (Optics)
N1  - Accession Number: 11019507; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 9/1/89, Vol. 262 Issue 9, p1158; Subject Term: RETINAL degeneration; Subject Term: OPACITY (Optics); Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zonderman, Alan B.
AU  - Costa Jr., Paul T.
AU  - McCrae, Robert R.
AU  - Zonderman, A B
AU  - Costa, P T Jr
AU  - McCrae, R R
T1  - Depression as a risk for cancer morbidity and mortality in a nationally representative sample.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09//9/1/89
VL  - 262
IS  - 9
M3  - journal article
SP  - 1191
EP  - 1195
SN  - 00987484
AB  - The relative risks for cancer morbidity and mortality associated with depressive symptoms were examined using data from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. The Center for Epidemiologic Studies Depression scale and the depression subscale from the General Well-being Schedule were used as predictors in this 10-year follow-up study of a nationally representative sample. No significant risk for cancer morbidity or mortality was associated with depressive symptoms with or without adjustment for age, sex, marital status, smoking, family history of cancer, hypertension, and serum cholesterol level. These data were also reanalyzed for subjects aged 55 years or older who were retraced by a second follow-up. Neither measure of depressive symptoms was a significant risk for cancer death during the 15-year follow-up interval. These results call into question the causal connection between depressive symptoms and cancer morbidity and mortality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER -- Mortality
KW  - MENTAL depression
KW  - HEALTH surveys
KW  - UNITED States
N1  - Accession Number: 11019450; Zonderman, Alan B. 1 Costa Jr., Paul T. 1 McCrae, Robert R. 1 Zonderman, A B 2 Costa, P T Jr McCrae, R R; Affiliation:  1: Gerontology Research Center National Institute on Aging, National Institute of Heart, Baltimore  2: Gerontology Research Center, National Institute on Aging, Baltimore, Md 21224; Source Info: 9/1/89, Vol. 262 Issue 9, p1191; Subject Term: CANCER -- Mortality; Subject Term: MENTAL depression; Subject Term: HEALTH surveys; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Swerlick, Robert A.
AU  - Yancey, Kim B.
AU  - Lawley, Thomas J.
T1  - Inflammatory Properties of Human C5a and C5a des Arg/ in Mast Cell-Depleted Human Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/09//
VL  - 93
IS  - 3
M3  - Article
SP  - 417
EP  - 422
SN  - 0022202X
AB  - C5a and its degradation product, C5a des Arg, elicit immediate cutaneous inflammatory reactions after intradermal injection. Histologically, these reactions are characterized by neutrophil-rich leukocytic infiltrates, leukocytoclasis, edema, and dermal mast cell degranulation. It has not been possible to assess in vivo the relative contributions of resident mast cells and circulating leukocytes to this reaction because the accumulation of leukocytes and degranulation of mast cells occur simultaneously after injection of these anaphylatoxins. To assess the role of mast cells in these inflammatory reactions, we have examined the reactivity of human skin selectively depleted of dermal mast cells by local corticosteroid treatment. Corticosteroid-treated skin became virtually devoid of dermal mast cells within 4-6 wk as assessed by light microscopy, immunofluorescence with fluorescein- conjugated avidin, or electron microscopy. Mast cell-depicted skin demonstrated normal vasopermeability and vasodilatory responsiveness to intradermal injection of histamine, but the reactivity of these sites to the mast cell secretagogue, morphine, was absent. Moreover, no clinical reactions were detectable in mast cell-depleted human skin after intradermal challenge with 50 ng of tither C5a or C5a des Arg, despite the fact that biopsies of these sites revealed substantial, neutrophil-rich infiltrates. These infiltrates were qualitatively and quantitatively identical to C5a or C5a des Mg-induced infiltrates in mast cell replete skin. This experimental approach in vivo has allowed the independent analysis of the anaphylactogenic and chemoattractant activities of human C5a and C5a des Arg in human skin, demonstrated the importance of dermal mast cells in these clinical responses. and shown that leukocytes can accumulate at these injection sites directly in response to these mediators. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INFLAMMATION -- Immunological aspects
KW  - INTRADERMAL injections
KW  - HISTOLOGY
KW  - EDEMA
KW  - MAST cells
KW  - IMMUNOFLUORESCENCE
N1  - Accession Number: 12280306; Swerlick, Robert A. 1 Yancey, Kim B. 2 Lawley, Thomas J. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Betheseda, Maryland, U.S.A.  2: Department of Dermatology, Uniformed Services University of the Health Sciences, Betheseda, Maryland, U.S.A.; Source Info: Sep89, Vol. 93 Issue 3, p417; Subject Term: INFLAMMATION -- Immunological aspects; Subject Term: INTRADERMAL injections; Subject Term: HISTOLOGY; Subject Term: EDEMA; Subject Term: MAST cells; Subject Term: IMMUNOFLUORESCENCE; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12280306
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Atkinson, Jane C.
AU  - Chih-Ko Yeh
AU  - Bermudez, Debra
AU  - Fox, Philip C.
AU  - Baum, Bruce J.
T1  - Longitudinal evaluation of major salivary gland function in HIV-1 infected patients.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1989/09//
VL  - 18
IS  - 8
M3  - Article
SP  - 469
EP  - 470
SN  - 09042512
AB  - Parotid and submandibular gland function were evaluated in 12 HIV antibody-positive men at two visits separated by a median interval of 14.5 months (range 6-22 months). Unstimulated and stimulated flow rates, and the concentrations of total protein, lysozyme, albumin and lactoferrin in these secretions, were determined. Parotid and submandibular gland secretions changed in a specific fashion with time. Lysozyme levels in both glandular stimulated secretions showed significant changes (≃40% and 70% elevated, between visits, in parotid and submandibular saliva, respectively). In addition, the frequency with which albumin was detected in unstimulated parotid secretions increased with time. These findings support earlier results suggesting the presence of alterations in major salivary gland function following HIV-1 infection. Submandibular gland function appears to manifest these alterations earlier, but with time the parotid secretions show similar changes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SALIVARY glands
KW  - EVALUATION
KW  - HIV-positive persons
KW  - HIV infections
KW  - AIDS
KW  - lysozyme
KW  - parotid gland
KW  - saliva
KW  - submandibular gland.
N1  - Accession Number: 11658960; Atkinson, Jane C. 1 Chih-Ko Yeh 1 Bermudez, Debra 1 Fox, Philip C. 1 Baum, Bruce J. 1; Affiliation:  1: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland USA; Source Info: Sep1989, Vol. 18 Issue 8, p469; Subject Term: SALIVARY glands; Subject Term: EVALUATION; Subject Term: HIV-positive persons; Subject Term: HIV infections; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: lysozyme; Author-Supplied Keyword: parotid gland; Author-Supplied Keyword: saliva; Author-Supplied Keyword: submandibular gland.; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1600-0714.ep11658960
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1991-10757-001
AN  - 1991-10757-001
AU  - Probstfield, Jeffrey L.
T1  - Adherence and its management in clinical trials: Implications for arthritis treatment trials.
JF  - Arthritis Care & Research
JO  - Arthritis Care & Research
JA  - Arthritis Care Res
Y1  - 1989/09//
VL  - 2
IS  - 3
SP  - S48
EP  - S57
CY  - US
PB  - John Wiley & Sons
SN  - 0893-7524
N1  - Accession Number: 1991-10757-001. PMID: 2487704 Other Journal Title: Arthritis & Rheumatism: Arthritis Care & Research. Partial author list: First Author & Affiliation: Probstfield, Jeffrey L.; NIH National Heart, Lung, and Blood Institute Div of Epidemiology & Clinical Applications, Clinical Trials Branch, Bethesda, MD, US. Release Date: 19910401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: Symposium: Compliance in rheumatoid arthritis (1989, Phoenix, Arizona). Major Descriptor: Arthritis; Cardiovascular Disorders; Clinical Trials; Drug Therapy; Treatment Compliance. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Clinical Trial; Empirical Study. Page Count: 10. Issue Publication Date: Sep, 1989. 
AB  - Reviews principles of adherence in clinical trials, using data and examples from trials examining cardiovascular diseases. Issues reviewed include the importance of adherence in clinical trials and an overall program for adherence in clinical trials. Discussion focuses on a program for the management of poor adherence among 305 participants in a coronary primary prevention trial. A multifaceted preventive approach to eliminate reduced adherence in a clinical trial is also presented. Findings have implications for adherence in clinical trials of arthritis treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - program for management of poor adherence in clinical trials
KW  - patients with cardiovascular diseases
KW  - implications for arthritis treatment
KW  - conference presentation
KW  - 1989
KW  - Arthritis
KW  - Cardiovascular Disorders
KW  - Clinical Trials
KW  - Drug Therapy
KW  - Treatment Compliance
KW  - 1989
DO  - 10.1002/anr.1790020314
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Lisker-Melman, Mauricic
AU  - Webb, David
AU  - Di Bisceglie, Adrian M.
AU  - Kassianides, Chris
AU  - Martin, Paul
AU  - Rustgi, Vinod
AU  - Waggoner, Jeanne G.
AU  - Park, Yoon
AU  - Hoofnagle, Jay H.
AU  - Lisker-Melman, M
AU  - Webb, D
AU  - Di Bisceglie, A M
AU  - Kassianides, C
AU  - Martin, P
AU  - Rustgi, V
AU  - Waggoner, J G
AU  - Park, Y
AU  - Hoofnagle, J H
T1  - Glomerulonephritis caused by chronic hepatitis B virus infection: treatment with recombinant human alpha-interferon.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1989/09/15/
VL  - 111
IS  - 6
M3  - journal article
SP  - 479
EP  - 483
SN  - 00034819
AB  - <bold>Study Objectives: </bold>To assess the efficacy of alpha-interferon therapy in patients with hepatitis B virus (HBV)-related glomerulonephritis.<bold>Design: </bold>Prospective, nonrandomized study.<bold>Patients: </bold>Five patients with persistence of hepatitis B surface antigen, hepatitis B e antigen (HBeAg) and HBV DNA in serum for at least 6 months and histologic changes of chronic hepatitis on liver biopsy as well as persistent proteinuria of greater than 2 g/d and histologic changes of glomerulonephritis on renal biopsy.<bold>Interventions: </bold>Patients received a 4-month course of recombinant human alpha-interferon (alfa-2b) beginning at a dose of 5 million units administered subcutaneously each day.<bold>Results: </bold>Serum levels of HBV DNA decreased in all patients and fell to undetectable levels during treatment in four of five patients. In the four responding patients, serum HBeAg disappeared, aminotransferases fell into the normal range, and a follow-up liver biopsy showed an improvement in the hepatocyte necrosis and inflammation. Urine protein excretion also decreased during treatment. In the four responding patients, urine protein excretion gradually fell to less than 1 g/d and serum albumin levels rose into the normal range. Resolution of the biochemical and serologic evidence of chronic hepatitis and glomerulonephritis was accompanied by disappearance of signs and symptoms of liver and kidney disease.<bold>Conclusions: </bold>A high proportion of patients with HBV-related glomerulonephritis will respond to a 4-month course of alpha-interferon with a clinical, biochemical, and serologic remission. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERFERONS -- Therapeutic use
KW  - HEPATITIS B virus
KW  - GLOMERULONEPHRITIS
KW  - PROTEINURIA
N1  - Accession Number: 6953838; Lisker-Melman, Mauricic Webb, David Di Bisceglie, Adrian M. Kassianides, Chris Martin, Paul Rustgi, Vinod Waggoner, Jeanne G. Park, Yoon Hoofnagle, Jay H. Lisker-Melman, M 1 Webb, D Di Bisceglie, A M Kassianides, C Martin, P Rustgi, V Waggoner, J G Park, Y Hoofnagle, J H; Affiliation:  1: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; Source Info: 9/15/89, Vol. 111 Issue 6, p479; Subject Term: INTERFERONS -- Therapeutic use; Subject Term: HEPATITIS B virus; Subject Term: GLOMERULONEPHRITIS; Subject Term: PROTEINURIA; Number of Pages: 5p; Illustrations: 2 Charts, 2 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Malloy, Michael H.
AU  - Rhoads, George G.
AU  - Schramm, Wayne
AU  - Land, Garland
T1  - Increasing Cesarean Section Rates in Very Low-Birth Weight Infants.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09/15/
VL  - 262
IS  - 11
M3  - Article
SP  - 1475
EP  - 1478
SN  - 00987484
AB  - Reports on the increase in the use of cesarean section for very low-birth weight infants in the U.S.  Potential benefit of cesarean section; Death rates in very low-birth weight infants; Relationship between the method of delivery and various ages at death; Health-related cases where cesarean section was used.
KW  - CESAREAN section
KW  - LOW birth weight
KW  - MORTALITY
KW  - UNITED States
N1  - Accession Number: 10982575; Malloy, Michael H. 1 Rhoads, George G. 1 Schramm, Wayne 2 Land, Garland 2; Affiliation:  1: Prevention Research Program, National Institute of Child Health and Human Development, Bethesda, Md  2: Missouri Department of Health, Jefferson City; Source Info: 9/15/89, Vol. 262 Issue 11, p1475; Subject Term: CESAREAN section; Subject Term: LOW birth weight; Subject Term: MORTALITY; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cooper, James R.
T1  - Methadone Treatment and Acquired Immunodeficiency Syndrome.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09/22/
VL  - 262
IS  - 12
M3  - Article
SP  - 1664
EP  - 1668
SN  - 00987484
AB  - Focuses on the effectiveness of methadone hydrochloride treatment in reducing intravenous opioid abuse and the associated sharing of injection equipment and possible transmission of AIDS.  Prevention of the spread of AIDS; Treatment evaluation; Disease prevention and treatment.
KW  - METHADONE hydrochloride
KW  - OPIOID abuse
KW  - AIDS (Disease)
N1  - Accession Number: 10976190; Cooper, James R. 1; Affiliation:  1: Office of Medical and International Affairs, National Institute of Drug Abuse; Source Info: 9/22/89, Vol. 262 Issue 12, p1664; Subject Term: METHADONE hydrochloride; Subject Term: OPIOID abuse; Subject Term: AIDS (Disease); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gordis, Enoch
AU  - Fuller, Richard K.
AU  - Hewitt, Brenda G.
AU  - Gordis, E
AU  - Fuller, R K
AU  - Hewitt, B G
T1  - Alcoholism treatment research: new directions for an old problem.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/09/22/
VL  - 262
IS  - 12
M3  - commentary
SP  - 1680
EP  - 1681
SN  - 00987484
AB  - Editorial.  Discusses directions to alcoholism treatment research.  Commentary on a study by W. Dorus' and colleagues concerning the effectiveness of lithium carbonate as a treatment for alcoholism; Factors to consider regarding patient compliance that deserve fuller attention before passing judgment on whether pharmacological studies and treatments for alcoholics can be implemented effectively; Importance of further evaluation of drug therapies; Development of markers of alcohol consumption.
KW  - ALCOHOLISM -- Treatment
KW  - PATIENT compliance
KW  - DRINKING of alcoholic beverages
KW  - ALCOHOLICS -- Rehabilitation
KW  - RESEARCH
N1  - Accession Number: 10976165; Gordis, Enoch 1 Fuller, Richard K. 1 Hewitt, Brenda G. 1 Gordis, E Fuller, R K Hewitt, B G; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism; Source Info: 9/22/89, Vol. 262 Issue 12, p1680; Subject Term: ALCOHOLISM -- Treatment; Subject Term: PATIENT compliance; Subject Term: DRINKING of alcoholic beverages; Subject Term: ALCOHOLICS -- Rehabilitation; Subject Term: RESEARCH; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 2p; Document Type: commentary
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Seuanez, Hector N.
T1  - Pattern of Late DNA Replication of the Allocyclic X Chromosome in Cebus apella and Leontopithecus rosalia chrysomelas Fibroblasts.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1989/10//
VL  - 19
IS  - 2
M3  - Article
SP  - 125
EP  - 130
SN  - 02752565
AB  - The pattern of the late DNA replication in the allocyclic X chromosome has been studied in the primary fibroblasts of two neotropical primates (Cebus apella and Leontopithecus rosalia chrysomelas). A comparison with previous reports showed a pattern identical with that of 1) the allocyclic S chromosome of human fibroblasts, and 2) the allocyclic X chromosome of rhesus and Cebus lymphocytes. Our results show that at least in one species (C. apella), and probably in rhesus and Leontopithecus, there is no tissue-specific difference between the late DNA replication patterns of the allocyclic X chromosome as there is between human lymphocytes and fibroblasts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANIMAL genetics
KW  - CEBUS apella
KW  - GOLDEN lion tamarin
KW  - DNA replication
KW  - FIBROBLASTS
KW  - CHROMOSOMES
KW  - allocyclic X chromosome
KW  - Cebus/Leontopithecus fibroblast
N1  - Accession Number: 12343665; Seuanez, Hector N. 1; Affiliation:  1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research Faculty, Maryland; Source Info: 1989, Vol. 19 Issue 2, p125; Subject Term: ANIMAL genetics; Subject Term: CEBUS apella; Subject Term: GOLDEN lion tamarin; Subject Term: DNA replication; Subject Term: FIBROBLASTS; Subject Term: CHROMOSOMES; Author-Supplied Keyword: allocyclic X chromosome; Author-Supplied Keyword: Cebus/Leontopithecus fibroblast; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Huang, Lien-fu
AU  - Cartwright, William S.
AU  - Hu, Teh-wei
T1  - Demand for Medigap insurance by the elderly: a micro-simulation analysis.
JO  - Applied Economics
JF  - Applied Economics
Y1  - 1989/10//
VL  - 21
IS  - 10
M3  - Article
SP  - 1325
PB  - Routledge
SN  - 00036846
AB  - In this paper, a micro-simulation model is developed to explain and estimate the optimum Medigap insurance coverage for elderly with different levels of insurance premium subsidy. The Medigap risk exposure is estimated from the 1977 National Medical Care Expenditure Utilization Survey, utilizing the gamma distribution. The theory of expected utility maximization is assumed and the model for health insurance demand is operationalized for hypothetical parameters for risk aversion, the price elasticity of demand, the loading fee and the subsidy. With the risk-aversion parameter at 0.0005, the price elasticity of medical-care demand at --0.5, loading costs at 9%, without any subsidy, the optimal Medigap co-insurance rate is 0.78; and with a premium subsidy of 60%, the co-insurance rate falls to 12%. The hypothetical price elasticity of demand for Medigap insurance is estimated to be between --0.44 and -- 1.02. More than half of the increase in medical expenditure resulting from an increase in premium subsidy from 0.35 to 0.60 is a welfare loss. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Applied Economics is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH insurance
KW  - HEALTH insurance claims
KW  - INSURANCE -- Rates
KW  - INSURANCE premiums
KW  - SUBSIDIES
KW  - INSURANCE
KW  - UNITED States
KW  - MEDIGAP
KW  - MEDICAL care for the aged
N1  - Accession Number: 4614394; Huang, Lien-fu 1; Cartwright, William S. 2; Hu, Teh-wei 3; Affiliations: 1: Department of Economics, Howard University, Washington, DC.; 2: Demography and Economics Office, National Institute on Aging.; 3: Department of Health Economics, University of California, Berkeley, Calif. USA.; Issue Info: Oct89, Vol. 21 Issue 10, p1325; Thesaurus Term: HEALTH insurance; Thesaurus Term: HEALTH insurance claims; Thesaurus Term: INSURANCE -- Rates; Thesaurus Term: INSURANCE premiums; Thesaurus Term: SUBSIDIES; Thesaurus Term: INSURANCE; Subject Term: UNITED States; Subject Term: MEDIGAP; Subject Term: MEDICAL care for the aged; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 524291 Claims Adjusting; NAICS/Industry Codes: 524299 All other insurance related activities; Number of Pages: 15p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Hall, Russell P.
AU  - Sanders, Martin E.
AU  - Duquesnoy, Rene J.
AU  - Katz, Stephen I.
AU  - Shaw, Stephen
T1  - Alterations in HLA-DP and HLA-DQ Antigen Frequency in Patients with Dermatitis Herpetiformis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/10//
VL  - 93
IS  - 4
M3  - Article
SP  - 501
EP  - 505
SN  - 0022202X
AB  - Dermatitis herpetiformis (DH) is associated with a markedly increased frequency of the HLA class II antigens DR3 and DQw2. To investigate a possible role of HLA-DP (or closely associated genes) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA-DR3 and HLA-DQw2 antigen frequency, we have typed 43 patients with DH for HLA-DP, HLA-DQ, and HLA-DR antigens. All patients with DH had typical clinical and histologic features, as well as granular deposits of IgA at the dermal-epidermal junction by direct immunofluorescence. HLA- DR3 was expressed in 41 of 43 (95%) DH patients, whereas HLA-DQw2 was expressed in all 43 (100%). The overall distribution of HLA-DP antigens in patients with DH was significantly different from that seen in all controls and in HLA-DR3 and HLA-DQw2 controls (p < 0.02). Examination of the frequency of individual DP antigens revealed that HLA-DPw1 was increased (42% of patients with DH vs 11% of all controls and 26% of DR3 positive controls), but this increase was not statistically greater than that expected due to the disequilibrium linkage of DPw1 with DR3/DQw2. Patients with DH, however, did have a statistically significant decreased frequency of DPw2 (14% of patients vs 31% of all controls and 41% of DR3 positive controls) (pc <0.05). Studies of three informative families demonstrated that the DPw2 genes of the DH patients were not present on the haplotype thought to carry a DH susceptibility gene (HLA-A1, HLA-B8, HLA-DR3, HLA-DQw2). A role of HLA-DP region genes in the pathogenesis of DH is further suggested by the observation that HLA-DPw1 was expressed in 82% (9 of 11) of DH patients with IgA antibodies against dietary antigens as compared with only 33% (4 of 12) of patients without IgA antibodies. HLA-DP genes or genes closely linked to them may be important in DH either as markers of the disease haplotype or by direct involvement in its pathogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DERMATITIS herpetiformis
KW  - HLA histocompatibility antigens
KW  - GENES
KW  - IMMUNOFLUORESCENCE
KW  - IMMUNITY
KW  - IMMUNOGLOBULINS
KW  - PATIENTS
N1  - Accession Number: 12284056; Hall, Russell P. 1 Sanders, Martin E. 2 Duquesnoy, Rene J. 3 Katz, Stephen I. 4 Shaw, Stephen 5; Affiliation:  1: Division of Dermatology, Duke University Medicine Center, Durham, North Carolina.  2: Immunology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  3: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.  4: Dermatology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  5: Department of Medicine, Duke University Medicine Center, Durham, North Carolina.; Source Info: Oct89, Vol. 93 Issue 4, p501; Subject Term: DERMATITIS herpetiformis; Subject Term: HLA histocompatibility antigens; Subject Term: GENES; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNITY; Subject Term: IMMUNOGLOBULINS; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12284056
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tylenda, Carolyn A.
AU  - Larsen, Janne
AU  - Yeh, Chih-ko
AU  - Lane, H. Clifford
AU  - Fox, Philip C.
T1  - High levels of oral yeasts in early HIV-1 infection.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1989/10//
VL  - 18
IS  - 9
M3  - Article
SP  - 520
EP  - 524
SN  - 09042512
AB  - Ten human immunedeficiency virus-1 (HIV-1) infected homosexual or bisexual individuals (ages 24-45) with no history of opportunistic infection were examined, by culture, for the presence of yeasts in whole saliva and on oral mucosa. All were HIV-1 antibody-positive men, non-smokers, non-denture wearers, and taking no medication. The mean salivary level of yeast was four logs higher in the HIV-1 infected group compared to a control group of normal, unmedicated, non-smoking men (ages 20-41) who denied any risk behavior for HIV-1 infection. Identification of the yeast in these HIV-1 positive individuals established that Canida albicans was the predominant species found in whole saliva and on buccal mucosa and tongue. Distinct hyphae were observed with only one mucosal sample. No significant correlation was found between whole saliva yeast concentration and the T4/T8 lymphocyte ratios or absolute number of T4 cells. No correlation was observed between oral yeast concentration and anti-C, albicans IgA titers. The high level of oral yeast in these individuals prior to the development of opportunistic infections is consistent with the suggestion that oral defense mechanisms are compromised in individuals following HIV-1 infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOUTH
KW  - YEAST
KW  - HIV infections
KW  - SALIVA
KW  - DIAGNOSIS
KW  - GAY people
KW  - BISEXUALS
KW  - Candida albtcans
KW  - candidiasis
KW  - HIV infection
KW  - oral
KW  - yeasts
N1  - Accession Number: 11658972; Tylenda, Carolyn A. 1 Larsen, Janne 1 Yeh, Chih-ko 1 Lane, H. Clifford 2 Fox, Philip C. 1; Affiliation:  1: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, Bethesda, Maryland, USA  2: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Oct1989, Vol. 18 Issue 9, p520; Subject Term: MOUTH; Subject Term: YEAST; Subject Term: HIV infections; Subject Term: SALIVA; Subject Term: DIAGNOSIS; Subject Term: GAY people; Subject Term: BISEXUALS; Author-Supplied Keyword: Candida albtcans; Author-Supplied Keyword: candidiasis; Author-Supplied Keyword: HIV infection; Author-Supplied Keyword: oral; Author-Supplied Keyword: yeasts; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2016-03727-001
AN  - 2016-03727-001
AU  - Krupp, Lauren B.
AU  - LaRocca, Nicholas G.
AU  - Muir-Nash, Joanne
AU  - Steinberg, Alfred D.
T1  - The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus.
JF  - Archives of Neurology
JO  - Archives of Neurology
JA  - Arch Neurol
Y1  - 1989/10//
VL  - 46
IS  - 10
SP  - 1121
EP  - 1123
CY  - US
PB  - American Medical Association
SN  - 0003-9942
SN  - 1538-3687
AD  - Krupp, Lauren B., Department of Neurology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY, US, 11794-8121
N1  - Accession Number: 2016-03727-001. PMID: 2803071 Other Journal Title: A.M.A. Archives of Neurology; JAMA Neurology. Partial author list: First Author & Affiliation: Krupp, Lauren B.; Department of Neurology, State University of New York at Stony Brook, Stony Brook, NY, US. Release Date: 20160204. Correction Date: 20160317. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: 40th Annual Meeting of the American Academy of Neurology, Apr, 1988, Cincinnati, OH, US. Conference Note: Read in part before the aforementioned conference. Major Descriptor: Chronic Illness; Fatigue; Multiple Sclerosis; Psychometrics; Rating Scales. Minor Descriptor: Lupus; Major Depression. Classification: Clinical Psychological Testing (2224); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Fatigue Severity Scale; Center for Epidemiologic Studies Depression Scale; Expanded Disability Status Scale DOI: 10.1037/t28980-000; Visual Analogue Scale. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1989. Publication History: Accepted Date: Apr 20, 1989. 
AB  - Fatigue is a prominent disabling symptom in a variety of medical and neurologic disorders. To facilitate research in this area, we developed a fatigue severity scale, subjected it to tests of internal consistency and validity, and used it to compare fatigue in two chronic conditions: systemic lupus erythematosus and multiple sclerosis. Administration of the fatigue severity scale to 25 patients with multiple sclerosis, 29 patients with systemic lupus erythematosus, and 20 healthy adults revealed that the fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time. Fatigue had a greater deleterious impact on daily living in patients with multiple sclerosis and systemic lupus erythematosus compared with controls. The results further showed that fatigue was largely independent of self-reported depressive symptoms and that several characteristics could differentiate fatigue that accompanies multiple sclerosis from fatigue that accompanies systemic lupus erythematosus. This study demonstrates (1) the clinical and research applications of a scale that measures fatigue severity and (2) helps to identify features that distinguish fatigue between two chronic medical disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - fatigue severity
KW  - systemic lupus erythematosus
KW  - multiple sclerosis
KW  - Fatigue Severity Scale
KW  - chronic conditions
KW  - psychometrics
KW  - 1989
KW  - Chronic Illness
KW  - Fatigue
KW  - Multiple Sclerosis
KW  - Psychometrics
KW  - Rating Scales
KW  - Lupus
KW  - Major Depression
KW  - 1989
U1  - Sponsor: National Institute on Disability and Rehabilitation Research, US. Grant: H133B80018. Recipients: No recipient indicated
U1  - Sponsor: Social Security Administration, US. Grant: RDP 12-D-70287-2-01. Recipients: No recipient indicated
DO  - 10.1001/archneur.1989.00520460115022
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Possible New Therapies for Ovarian Cancers.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/10/06/
VL  - 262
IS  - 13
M3  - Article
SP  - 1748
EP  - 1748
SN  - 00987484
AB  - Describes emerging therapeutic approaches for ovarian cancers featured in studies supported by the United States National Institutes of Health (NIH).  Effectiveness of taxol therapy; Results of clinical trials for cisplatin-based combination chemotherapy.
KW  - OVARIAN diseases
KW  - CANCER treatment
KW  - TREATMENT
N1  - Accession Number: 10981884; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 10/6/89, Vol. 262 Issue 13, p1748; Subject Term: OVARIAN diseases; Subject Term: CANCER treatment; Subject Term: TREATMENT; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Low CD4 Counts Predictive of Opportunistic Pneumonias in HIV Infection.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/10/06/
VL  - 262
IS  - 13
M3  - Article
SP  - 1748
EP  - 1748
SN  - 00987484
AB  - Reports that below-average CD4 lymphocyte counts appear to predict opportunistic pulmonary infections in patients infected with human immunodeficiency virus according to scientists at the National Institutes of Health Clinical Center.
KW  - CD4 antigen
KW  - LYMPHOCYTES
KW  - RESPIRATORY diseases
KW  - HIV-positive persons
N1  - Accession Number: 10981885; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 10/6/89, Vol. 262 Issue 13, p1748; Subject Term: CD4 antigen; Subject Term: LYMPHOCYTES; Subject Term: RESPIRATORY diseases; Subject Term: HIV-positive persons; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Possible Mechanism of Platelet Underproduction in HIV-infected Patients.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/10/06/
VL  - 262
IS  - 13
M3  - Article
SP  - 1748
EP  - 1748
SN  - 00987484
AB  - Reports that human immunodeficiency virus directly infects megakaryocytes and may contribute to the pathogenesis of thrombocytopenia in patients infected with HIV according to study findings from the National Institutes of Health.
KW  - HIV (Viruses)
KW  - MEGAKARYOCYTES
KW  - THROMBOCYTOPENIA
KW  - HIV-positive persons
N1  - Accession Number: 10981886; Raub, William 1; Source Information: 10/6/89, Vol. 262 Issue 13, p1748; Subject: HIV (Viruses); Subject: MEGAKARYOCYTES; Subject: THROMBOCYTOPENIA; Subject: HIV-positive persons; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Pizzo, Philip A.
T1  - Emerging Concepts in the Treatment of HIV Infection in Children.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/10/13/
VL  - 262
IS  - 14
M3  - Article
SP  - 1989
EP  - 1992
SN  - 00987484
AB  - Discusses concepts in the treatment of HIV infection in children.  Focus on the case of a 16-month-old child who was diagnosed with HIV infection at four months of age when she developed acute interstitial pneumonia; HIV seropositive condition of the mother; Epidemiology of HIV; HIV transmission; Difficulty in diagnosing HIV infection in a child who is less than 15 months of age; Description of treatment methods using zidovudine; Development of neurodevelopmental abnormalities.
KW  - HIV infections -- Treatment
KW  - AIDS (Disease) in children
KW  - AZT (Drug)
KW  - DEVELOPMENTAL disabilities
N1  - Accession Number: 10981362; Pizzo, Philip A. 1; Affiliation:  1: Pediatric Branch, National Cancer Institute, National Institute of Health, Bethesda, Md; Source Info: 10/13/89, Vol. 262 Issue 14, p1989; Subject Term: HIV infections -- Treatment; Subject Term: AIDS (Disease) in children; Subject Term: AZT (Drug); Subject Term: DEVELOPMENTAL disabilities; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Glass, Andrew G.
AU  - Hoover, Robert N.
T1  - The Emerging Epidemic of Melanoma and Squamous Cell Skin Cancer.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/10/20/
VL  - 262
IS  - 15
M3  - Article
SP  - 2097
EP  - 2100
SN  - 00987484
AB  - Describes the basic epidemiologic features of melanoma and squamous cell skin cancer.  Incidence and time trends; Factors influencing the prevalence of cancer; Diagnosis and treatment characteristics.
KW  - SKIN -- Cancer
KW  - SQUAMOUS cell carcinoma
KW  - DIAGNOSIS
KW  - EPIDEMICS
N1  - Accession Number: 10981420; Glass, Andrew G. 1 Hoover, Robert N. 2; Affiliation:  1: Center for Health Research, Kaiser Permanente  2: Environmental Epidemiology Branch, National Cancer Institute; Source Info: 10/20/89, Vol. 262 Issue 15, p2097; Subject Term: SKIN -- Cancer; Subject Term: SQUAMOUS cell carcinoma; Subject Term: DIAGNOSIS; Subject Term: EPIDEMICS; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Horm, John W.
AU  - Sondik, Edward J.
T1  - Person-Years of Life Lost Due to Cancer in the United States, 1970 and 1984.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/11//
VL  - 79
IS  - 11
M3  - Article
SP  - 1490
EP  - 1493
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The number of deaths due to cancer in the United States reached an all-time high of 453,450 deaths in 1984 and, due to the dynamics of population growth, will continue to increase if the risk of dying from cancer does not change.  Between 1970 and 1984, the total Person-Years of Life Lost (PYLL), the sum of the difference between the actual age at death and the expected remaining lifetime for each person who died of cancer, increased for most cancer sites as well as for all sites combined. In 1984, 6,881,281 person-years of life were lost due to cancer deaths, up from 5,303,668 in 1970. The exceptions are those cancers for which there has been major progress in either prevention or treatment; e.g., stomach and cervix uteri (prevention) and testicular, Hodgkin's disease, leukemia, and childhood cancers (treatment).  The Average Years of Life Lost (AYLL) per person dying from cancer in 1984 was generally less than in 1970. Overall, each person who died from cancer in 1984 died 15.2 years earlier than his/her life expectancy. The greatest loss was for those who died of childhood cancers (66.9 years earlier), followed by testicular cancer (35.8 years earlier). The least loss relative to the expectation of life was for those who died of prostate cancer. The 25,400 men who died from prostate cancer in 1984 died an average of nine years earlier than otherwise expected. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MORTALITY
KW  - CANCER
KW  - CANCER patients
KW  - POPULATION
KW  - CERVICAL cancer
KW  - CANCER in children
KW  - LEUKEMIA
KW  - HODGKIN'S disease
KW  - LIFE expectancy
KW  - UNITED States
N1  - Accession Number: 4687526; Horm, John W. 1 Sondik, Edward J. 2; Affiliation:  1: Statistician, Special Populations Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN-240, 9000 Rockville Pike, Bethesda, MD 20892.  2: Acting Associate Director, Cancer Control Sciences Program, DCPC, NCI.; Source Info: Nov89, Vol. 79 Issue 11, p1490; Subject Term: MORTALITY; Subject Term: CANCER; Subject Term: CANCER patients; Subject Term: POPULATION; Subject Term: CERVICAL cancer; Subject Term: CANCER in children; Subject Term: LEUKEMIA; Subject Term: HODGKIN'S disease; Subject Term: LIFE expectancy; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thompson, Grey B.
AU  - Kessler, Larry G.
AU  - Boss, Leslie P.
T1  - Breast Cancer Screening Legislation in the United States: A Commentary.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/11//
VL  - 79
IS  - 11
M3  - Article
SP  - 1541
EP  - 1543
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We discuss some of the issues emerging from a powerful legislative movement for preventive services over the past three years. During this time an increasing number of states passed, considered, or are currently developing breast cancer screening legislation. Most of these laws require some form of third party payment for mammography or establish breast cancer screening programs. The legislation varies markedly with regard to periodicity of examinations, ages covered, type and extent of third party coverage, dosage regulation, and radiographic equipment standards. This shows a need for common standards. Legislation provides an essential incentive for a public health response to a serious problem, but more than laws are needed. Health care providers and the general public need to be aware and take advantage of the coverage provided as a result of legislation. Moreover, public health officials need to be aware that such legislation may lead to a demand for services that exceeds present capacity to deliver them. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL laws & legislation
KW  - MEDICAL screening
KW  - BREAST cancer
KW  - CANCER in women
KW  - MAMMOGRAMS
KW  - HEALTH insurance
KW  - MEDICAL care
KW  - PUBLIC health
KW  - UNITED States
N1  - Accession Number: 4690539; Thompson, Grey B. 1 Kessler, Larry G. 2 Boss, Leslie P. 3; Affiliation:  1: Followback Survey Branch, National Center for Health Statistics, Center Building Rm 1-44, 3700 East West Highway, Hyattsville, MD 20782.  2: Applied Research Branch, National Cancer Institute, Division of Cancer Prevention and Control, Rockville, MD.  3: Cancer Control Applications Branch, National Cancer Institute, Division of Cancer Prevention and Control, Rockville, MD.; Source Info: Nov89, Vol. 79 Issue 11, p1541; Subject Term: MEDICAL laws & legislation; Subject Term: MEDICAL screening; Subject Term: BREAST cancer; Subject Term: CANCER in women; Subject Term: MAMMOGRAMS; Subject Term: HEALTH insurance; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Dicker, Barbara G.
AU  - Cherkin, Dan
AU  - Egilman, David
AU  - Feldman, Robert H. L.
AU  - Grazzini, Grazia
AU  - Cecchiai, Silvia
AU  - Bartoli, Dusca
AU  - Ciatto, Stefano
AU  - Schade, Charles P.
AU  - Lambert, Elizabeth Y.
AU  - Harkess, John R.
AU  - Jelliffe, Derrick B.
AU  - Jelliffe, E. F. Patrice
AU  - Garn, Stanley M.
T1  - Risk of AIDS among Lesbians.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/11//
VL  - 79
IS  - 11
M3  - Letter
SP  - 1569
EP  - 1569
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented regarding the risk of AIDS (acquired immunodeficiency syndrome) in the female homosexual community.  INSET: Small Copayment Reduced Primary Care Office Visits in HMO.
KW  - LETTERS to the editor
KW  - AIDS (Disease) -- Risk factors
N1  - Accession Number: 4690740; Dicker, Barbara G. 1 Cherkin, Dan 2 Egilman, David 3 Feldman, Robert H. L. 4 Grazzini, Grazia 5 Cecchiai, Silvia 6 Bartoli, Dusca 5 Ciatto, Stefano 5 Schade, Charles P. 7 Lambert, Elizabeth Y. 8 Harkess, John R. 9 Jelliffe, Derrick B. 10 Jelliffe, E. F. Patrice 11 Garn, Stanley M. 12,13,14; Affiliation:  1: Research Fellow, Health Services Research and Development (152), Seattle Veterans Administration Medical Center, 1660 South Columbia Way, Seattle, WA 98108.  2: Center for Health Studies, Group Health Cooperative of Puget Sound, 521 Wall Street, Seattle, WA 98121.  3: Training Exchange, 90 West Street, Foxboro, MA 02035.  4: Director, Program in Health Behavior  5: Associate Professor of Health Education, University of Maryland, Suite 2387 PERH Bldg., College Park, MD 20742.  6: Oncologist, Centro per lo Studio e la Prevenzione Oncologica, Viale A. Volta 171, Firenze, I-50131, Italia.  7: American Public Health Association, 1015 15th St, NW, Washington, DC 20005.  8: National Institute on Drug Abuse, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857.  9: Epidemiology Service, Oklahoma State Department of Health, Box 53551, Oklahoma City, OK 73152.  10: Professor of Public Health and Pediatrics, UCLA.  11: Researcher and Lecturer in Public Health, University of California, Los Angeles, School of Public Health, 10833 Le Conte Avenue, Los Angeles, CA 90024-1772.  12: Fellow, Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 8109-0406.  13: Professor of Anthropology, University of Michigan, Ann Arbor, MI 8109-0406.  14: Professor of Nutrition, University of Michigan, Ann Arbor, MI 8109-0406.; Source Info: Nov89, Vol. 79 Issue 11, p1569; Subject Term: LETTERS to the editor; Subject Term: AIDS (Disease) -- Risk factors; Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Schade, Charles P.
AU  - Lambert, Elizabeth Y.
T1  - Factors in Hepatitis A Transmission.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/11//
VL  - 79
IS  - 11
M3  - Letter
SP  - 1571
EP  - 1571
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article on Hepatitis A in drug abusers by J. Harkess and colleagues that was published in an issue.
KW  - LETTERS to the editor
KW  - HEPATITIS A
N1  - Accession Number: 21088352; Schade, Charles P. 1 Lambert, Elizabeth Y. 2; Affiliation:  1: American Public Health Association, 1015 15th St, NW, Washington, DC 20005  2: national Institute on Drug Abuse, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Nov89, Vol. 79 Issue 11, p1571; Subject Term: LETTERS to the editor; Subject Term: HEPATITIS A; Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lawlor, Brian A.
AU  - Sunderland, Trey
AU  - Mellow, Alan M.
AU  - Hill, James L.
AU  - Newhouse, Paul A.
AU  - Murphy, Dennis L.
T1  - Family history of depression and alcoholism in Alzheimer patients and age-matched controls.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1989/11//
VL  - 4
IS  - 6
M3  - Article
SP  - 327
EP  - 331
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - Depression and depressive symptoms are reported to occur frequently in patients with Alzheimer's disease; however, familial and psychobiological contributions associated with depression in Alzheimer patients are poorly understood. In this study, we compared family history of depression and alcoholism in 44 patients with probable Alzheimer's disease and 38 aged-matched cognitively intact controls. Results from comparison showed no overall difference between the occurrence of depression in first-degree relatives of Alzheimer patients compared to first-degree relatives of controls. There was, however, significantly lower incidence of alcoholism in relatives of Alzheimer patients, particularly male relatives (p<0.05). This finding suggests that family history and depression alone may not fully explain the high rate of depression in Alzheimer patients and that other factors including neurochemical changes in the brains of Alzheimer patients should be considered. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AFFECTIVE disorders
KW  - GENEALOGY
KW  - ALZHEIMER'S disease
KW  - PATHOLOGICAL psychology
KW  - PRESENILE dementia
KW  - Affective disorder
KW  - Alzheimer's disease
KW  - dementia
KW  - family history
N1  - Accession Number: 23633565; Lawlor, Brian A. 1 Sunderland, Trey 1 Mellow, Alan M. 2 Hill, James L. 2 Newhouse, Paul A. 3 Murphy, Dennis L. 2; Affiliation:  1: Chief, Outpatient Studies, and Chief, Unit on Geriatric Psychopharmacology, Bethesda, MD, USA  2: Chief, Laboratory of Clinical Science, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA  3: Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC, USA; Source Info: Nov1989, Vol. 4 Issue 6, p327; Subject Term: AFFECTIVE disorders; Subject Term: GENEALOGY; Subject Term: ALZHEIMER'S disease; Subject Term: PATHOLOGICAL psychology; Subject Term: PRESENILE dementia; Author-Supplied Keyword: Affective disorder; Author-Supplied Keyword: Alzheimer's disease; Author-Supplied Keyword: dementia; Author-Supplied Keyword: family history; NAICS/Industry Codes: 812990 All Other Personal Services; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hauser, Conrad
AU  - Yokoyama, Wayne M.
AU  - Katz, Stephen I.
T1  - Characterization of Primary T Helper Cell Activation and T Helper Cell Lines Stimulated by Hapten-modified, Cultured Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1989/11//
VL  - 93
IS  - 5
M3  - Article
SP  - 649
EP  - 655
SN  - 0022202X
AB  - It has recently been shown that hapten-modified cultured Langerhans cells are able to activate small resting syngeneic L3T4+ T helper cells from nonsensitized animals. Repeated stimulation of these T cells with hapten-modified cultured Langerhans cells leads to the establishment of L3T4+ hapten-specific interleukin-4-producing T-cell lines. Here we report on further characteristics of primary hapten-dependent activation of L3T4+ T cells and of T-cell lines derived from them. Dendritic cell-enriched spleen cells were as able as Langerhans cells to activate nonsensitized T helper cells after hapten modification. However, M12c, a major histocompatibility complex class II-positive B-cell line that was able to activate small, resting, allogeneic L3T4+ T cells was not able to stimulate syngeneic T helper cells after hapten modification. Thy1+ dendritic epidermal cells did not significantly affect the magnitude of primary T helper cell proliferation induced by cultured Langerhans cells. Restimulation of in vitro primed T helper cells with hapten-modified cultured Langerhans cells revealed the presence, within the primed T helper cell population, of activated cells with specificity to an unrelated hapten, suggesting that, in hapten-dependent T helper cell activation, hapten-nonspecific cells are activated along with those that are hapten specific. Restimulation of a hapten-specific long-term T helper cell subline using different antigen-presenting cell types demonstrates that factors other than major histocompatibility complex class II density or tissue derivation of the antigen-presenting cell play a role in the activation of T cells in vitro. Finally, we demonstrate that in vitro generated hapten-specific T helper cell lines may show strict major histocompatibility complex restriction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - HAPTENS
KW  - T cells
KW  - CELL lines
KW  - INTERLEUKIN-4
KW  - CELL proliferation
KW  - HISTOCOMPATIBILITY
N1  - Accession Number: 12319814; Hauser, Conrad 1 Yokoyama, Wayne M. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Immunology, National Institute of Allergic and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov89, Vol. 93 Issue 5, p649; Subject Term: LANGERHANS cells; Subject Term: HAPTENS; Subject Term: T cells; Subject Term: CELL lines; Subject Term: INTERLEUKIN-4; Subject Term: CELL proliferation; Subject Term: HISTOCOMPATIBILITY; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12319814
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gilmore Jr., R. D.
AU  - Joste, N.
AU  - McDonald, G. A.
T1  - Cloning, expression and sequence analysis of the gene encoding the 120kD surface-exposed protein of Rickettsia rickettsii.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1989/11//
VL  - 3
IS  - 11
M3  - Article
SP  - 1579
EP  - 1586
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Rickettsia rickettsii (R strain) genomic DNA was partially digested and cloned into the lambda expression vector gt11 generating a genomic clone bank. Transformant plaques were screened with antisera generated against the 120 kiloDalton protein of R rickettsii to detect those phage expressing the recombinant protein. The gene encoding the 120kD protein was localized to a 4.3 kilobase Sphl-BamHI fragment from the recombinant phage and subcloned into pUC18 and pUC19. Full-length expression of the recombinant protein was achieved with both orientations. The gene and flanking regions were sequenced. The p120 gene consists of 3900 base pairs coding for 1300 amino acids. A distinguishable promoter region was not identified, although there are several 5′ sequences that resemble classical prokaryotic promoters. Downstream of the termination codon for this gene lies a 726 base pair open reading frame on the opposite strand with the potential to encode a protein of approximately 27 kD. The identity of this putative gene product is unknown. The two open reading frames are separated by a 106 base pair intergenic region that consists of a stretch of dyad symmetry resembling rho-independent transcriptional terminators. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Genetic engineering
KW  - Genetics
KW  - Gene expression
KW  - Recombinant proteins
KW  - Genetic transcription
KW  - Genomics
N1  - Accession Number: 18286969; Gilmore Jr., R. D. 1; Joste, N. 1,2; McDonald, G. A. 1,3; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, 59840, USA; 2: Dept . of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA; 3: Dept. of Microbiology, University of Missouri, Columbia, MO 65212, USA; Issue Info: Nov1989, Vol. 3 Issue 11, p1579; Thesaurus Term: Genetic engineering; Thesaurus Term: Genetics; Subject Term: Gene expression; Subject Term: Recombinant proteins; Subject Term: Genetic transcription; Subject Term: Genomics; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Johnson Jr., Ray
T1  - Auditory and Visual P300s in Temporal Lobectomy Patients: Evidence for Modality-Dependent Generators.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1989/11//
VL  - 26
IS  - 6
M3  - Article
SP  - 633
EP  - 650
SN  - 00485772
AB  - The P300 component of the event-related brain potential (ERP) was studied in epileptic patients with unilateral resections of medial temporal lobe areas of the brain. The patients and controls were tested in an oddball paradigm in two conditions: counting and reaction time. Both auditory and visual stimuli were used to elicit ERP activity in different blocks. Despite the reported presence of locally-generated auditory and visual P300-1ike potentials in these areas, no evidence was found of any surgically-related hemispheric asymmetries in the scalp distribution of the P300 or Slow Wave for stimuli in either modality. Moreover, compared to normal controls, there were no significant reductions in overall P300 amplitude in the patients. The patients did show a double dissociation in their frontal ERP activity: the left temporal lobectomy patients showed apparent decreased frontal auditory P300 amplitudes but normal visual P300 amplitudes, whereas the right temporal lobectomy patients showed the opposite pattern. These results appeared to be due to the presence of a longduration slow wave rather than to alterations in P300 amplitude. These data do not support the presence of a significant contribution by u hippocampal/amygdala generator to the activity of the scalp-recorded P300 in the oddball paradigm. Topographic comparisons on normalized amplitudes revealed significantly different scalp distributions as a function of stimulus modality, event probability, and task for both the P300 and Slow Wave components. These data indicate that the amplitude variations associated with each experimental variable are due to the activity of a separate underlying neural source. The sources of task and probability effects on P300 and Slow Wave amplitude each appeared to be modality-independent generators. The nature of the third, modality-related generator is less clear. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BRAIN
KW  - EPILEPTICS
KW  - REACTION time
KW  - DEVELOPMENTALLY disabled
KW  - PSYCHOPHYSIOLOGY
KW  - SLOW wave sleep
KW  - eventrelated potentials.
KW  - neural generators
KW  - p300
KW  - slow wave
KW  - temporal lobectomy patients
N1  - Accession Number: 11034612; Johnson Jr., Ray 1; Affiliation:  1: Cognitive Neuroscience Unit, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland; Source Info: Nov1989, Vol. 26 Issue 6, p633; Subject Term: BRAIN; Subject Term: EPILEPTICS; Subject Term: REACTION time; Subject Term: DEVELOPMENTALLY disabled; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: SLOW wave sleep; Author-Supplied Keyword: eventrelated potentials.; Author-Supplied Keyword: neural generators; Author-Supplied Keyword: p300; Author-Supplied Keyword: slow wave; Author-Supplied Keyword: temporal lobectomy patients; Number of Pages: 18p; Document Type: Article
L3  - 10.1111/1469-8986.ep11034612
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson Jr., Ray
T1  - Developmental Evidence for Modality-Dependent P300 Generators: A Normative Study.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1989/11//
VL  - 26
IS  - 6
M3  - Article
SP  - 651
EP  - 667
SN  - 00485772
AB  - The behavior of the early and late components of the event-related brain potential (ERP) elicited by auditory and visual stimuli was studied in 40 normal females between the ages of 7 and 20. The ERPs were collected using two different tasks (i.e., count and reaction time) in an oddball paradigm. Analysis of the early component (i.e., N1, P2, N2) latencies revealed small hut significant decreases with age in the visual modality hut no change in the auditory modality. Except for the visual N1, early component amplitudes did not change significantly over this age range. The results showed that auditory and visual P300 latencies, but not amplitude, changed at significantly different rates over this age range. P300 latencies in the auditory modality showed a relatively abrupt change around age 12, after which P300 latencies changed little and were essentially at their adult levels. The latencies of visual P300s showed a much smaller and more steady decrease with age. Thus visual P300 latencies were shorter than auditory P300s in young children but longer than auditory P300s in older children. Significantly different scalp distributions were found for auditory and visual P300s. Although all P300 activity was maximal over parietal scalp, visual P300s were significantly larger than auditory P300s over central and frontal scalp. The developmental differences, combined with the presence of significantly different scalp topographies for auditory and visual P300s, provide convergent evidence that P300 activity is not independent of the modality of the eliciting stimulus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BRAIN
KW  - CHILD development
KW  - AUDITORY adaptation
KW  - CHILDREN
KW  - DEVELOPMENTAL psychobiology
KW  - PSYCHOPHYSIOLOGY
KW  - children
KW  - development.
KW  - early components
KW  - event-related potentials
KW  - p300
N1  - Accession Number: 11034618; Johnson Jr., Ray 1; Affiliation:  1: Cognitive Neuroscience Unit, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: Nov1989, Vol. 26 Issue 6, p651; Subject Term: BRAIN; Subject Term: CHILD development; Subject Term: AUDITORY adaptation; Subject Term: CHILDREN; Subject Term: DEVELOPMENTAL psychobiology; Subject Term: PSYCHOPHYSIOLOGY; Author-Supplied Keyword: children; Author-Supplied Keyword: development.; Author-Supplied Keyword: early components; Author-Supplied Keyword: event-related potentials; Author-Supplied Keyword: p300; Number of Pages: 17p; Document Type: Article
L3  - 10.1111/1469-8986.ep11034618
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DP  - EBSCOhost
DB  - aph
ER  - 
TY  - JOUR
AU  - Zahn, Theodore P.
T1  - The Psychology of Fear and Stress (Book).
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1989/11//
VL  - 26
IS  - 6
M3  - Book Review
SP  - 718
EP  - 719
SN  - 00485772
AB  - Reviews the book "The Psychology of Fear and Stress," 2nd ed., by Jeffrey Alan Gray.
KW  - PSYCHOLOGY
KW  - NONFICTION
KW  - GRAY, Jeffrey Alan
KW  - PSYCHOLOGY of Fear & Stress, The (Book)
N1  - Accession Number: 11034675; Zahn, Theodore P. 1; Affiliation:  1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD 20892; Source Info: Nov1989, Vol. 26 Issue 6, p718; Subject Term: PSYCHOLOGY; Subject Term: NONFICTION; Reviews & Products: PSYCHOLOGY of Fear & Stress, The (Book); People: GRAY, Jeffrey Alan; Number of Pages: 2p; Document Type: Book Review
L3  - 10.1111/1469-8986.ep11034675
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Possible New Treatment for an Immunodeficiency Disease.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/11/03/
VL  - 262
IS  - 17
M3  - Article
SP  - 2359
EP  - 2359
SN  - 00987484
AB  - Focuses on the possible use of the recombinant interleukin 2 in the treatment of a distinct form of severe combined immunodeficiency disease according to study findings from the National Institutes of Health.
KW  - INTERLEUKIN-2
KW  - IMMUNODEFICIENCY
N1  - Accession Number: 10975623; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 11/3/89, Vol. 262 Issue 17, p2359; Subject Term: INTERLEUKIN-2; Subject Term: IMMUNODEFICIENCY; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Genetics May Determine Response to Hepatitis B Vaccine.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/11/03/
VL  - 262
IS  - 17
M3  - Article
SP  - 2359
EP  - 2359
SN  - 00987484
AB  - Reports that immune responsiveness to hepatitis B surface antigen depend on whether a person has a dominant immune-responsive gene according to study findings from the National Institutes of Health.  Changes observed in each of the four injections.
KW  - HEPATITIS B
KW  - ANTIGENS
KW  - VACCINATION
KW  - GENETIC aspects
N1  - Accession Number: 10975624; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 11/3/89, Vol. 262 Issue 17, p2359; Subject Term: HEPATITIS B; Subject Term: ANTIGENS; Subject Term: VACCINATION; Subject Term: GENETIC aspects; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - High-Fiber Diet May Inhibit Large-Bowel Neoplasia.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/11/03/
VL  - 262
IS  - 17
M3  - Article
SP  - 2359
EP  - 2359
SN  - 00987484
AB  - Focuses on the potentials of a high-fiber diet in inhibiting neoplasia in the large intestines according to an analysis of a subset of patients in a nutritional intervention trial.  Conclusions that consumption of supplements of at least 11 grams of grain fiber may inhibit rectal polyp development.
KW  - HIGH-fiber diet
KW  - LARGE intestine
KW  - TUMORS
N1  - Accession Number: 10975625; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 11/3/89, Vol. 262 Issue 17, p2359; Subject Term: HIGH-fiber diet; Subject Term: LARGE intestine; Subject Term: TUMORS; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Molecular Abnormality Seen in Leukemia Progression.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/11/03/
VL  - 262
IS  - 17
M3  - Article
SP  - 2359
EP  - 2359
SN  - 00987484
AB  - Reports that alterations in the p53 gene may be associated with the clinical progression of chronic myelocytic leukemia according to study findings released by the National Institutes of Health.  Details of the structural abnormalities.
KW  - P53 antioncogene
KW  - MYELOID leukemia -- Genetics
N1  - Accession Number: 10975626; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 11/3/89, Vol. 262 Issue 17, p2359; Subject Term: P53 antioncogene; Subject Term: MYELOID leukemia -- Genetics; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Possible New Treatment for an Immunodeficiency Disease.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/11/03/
VL  - 262
IS  - 17
M3  - Article
SP  - 2359
EP  - 2359
SN  - 00987484
AB  - Focuses on the possible use of the recombinant interleukin 2 in the treatment of a distinct form of severe combined immunodeficiency disease according to study findings from the National Institutes of Health.
KW  - INTERLEUKIN-2
KW  - IMMUNODEFICIENCY
N1  - Accession Number: 10975623; Raub, William 1; Source Information: 11/3/89, Vol. 262 Issue 17, p2359; Subject: INTERLEUKIN-2; Subject: IMMUNODEFICIENCY; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Hubbard, Michael J.
AU  - Klee, Claude B.
T1  - Characterization of a high-affinity monoclonal antibody to calcineurin whose epitope defines a new structural domain of calcineurin A.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/11/06/
VL  - 185
IS  - 2
M3  - Article
SP  - 411
EP  - 418
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Monoclonal antibodies have been raised against native calcineurin using conventional in vitro immunization and hybridoma procedures. The relatively high affinity of nonimmune IgG for the two subunits of calcineurin resulted in large nonspecific binding values for immunoassays of native, dissociated and denatured calcineurin, which complicated the antibody screening. Monoclonal aCn5, a high-affinity IgG1 that exhibits specific binding, was characterized. Other calmodulin-binding proteins tested were not recognized by aCn5. Simple binding properties were exhibited in solid-phase experiments, Kd = 26 ( ± 4) pM, but the stoichiometry was low. The loss of immunoreactivity alter denaturation of calcineurin indicated that the aCn5 epitope is of the assembled topographic, not segmental, type. The epitope was located to the A subunit and affinity was unaffected by the presence of calcineurin B. The epitope remained intact after proteolytic removal of the amino-terminal 20 residues of calcineurin A essential for phosphatase activity, and the carboxyl-terminal inhibitory and calmodulin-binding domains. The calmodulin-binding peptide derived from calcineurin, cA8, was not recognized by aCn5. Addition of Ca2+, Mn2+, Ni2+, chelators or dithiothreitol did not influence the affinity of aCn5 for the holoenzyme. Phosphatase activity of calcineurin, in the presence and absence of calmodulin and after removal of the inhibitory domain, was little affected by aCn5. Thus, the aCn5 epitope defines a previously unidentified structural domain of calcineurin A located in a region of the proteolytically resistant core that is topologically distinct from the catalytic. inhibitory, calmodulin-binding and calcineurin-B-binding domains, and not functionally connected with calcineurin B or the putative metal-binding domain(s). [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - ANTIGENIC determinants
KW  - HYBRIDOMAS
KW  - IMMUNOASSAY
KW  - MONOCLONAL antibodies
KW  - CALMODULIN
N1  - Accession Number: 23563675; Hubbard, Michael J. 1 Klee, Claude B. 1; Affiliation:  1: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD.; Source Info: 11/6/89, Vol. 185 Issue 2, p411; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENIC determinants; Subject Term: HYBRIDOMAS; Subject Term: IMMUNOASSAY; Subject Term: MONOCLONAL antibodies; Subject Term: CALMODULIN; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Cooreman, J.
AU  - Keller, J. B.
AU  - Higgins, M. W.
T1  - Susceptibility to Respiratory Conditions.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1989/12//
VL  - 79
IS  - 12
M3  - Letter
SP  - 1679
EP  - 1679
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented concerning the comparison between the relative risks of respiratory conditions for light and heavy smoking versus nonsmoking males and females in an American and a French population.
KW  - LETTERS to the editor
KW  - SMOKING
N1  - Accession Number: 22492718; Cooreman, J. 1 Keller, J. B. 2 Higgins, M. W. 2; Affiliation:  1: Institut National de la Santé et de la Recherche M6dicale, Unité226, Epidédes Maladies Respiratoires, Eaculté Xavier Bichat-16, Rue Henri Huchard, 75018 Paris, France  2: National Heart, Lung and Blood Institute, Bethesda, Maryland 20892; Source Info: Dec1989, Vol. 79 Issue 12, p1679; Subject Term: LETTERS to the editor; Subject Term: SMOKING; Number of Pages: 2/5p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
AU  - Schooler, Carmi
AU  - Schoenbach, Carrie
T1  - SELF-ESTEEM AND ADOLESCENT PROBLEMS:  MODELING RECIPROCAL EFFECTS.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1989/12//
VL  - 54
IS  - 6
M3  - Article
SP  - 1004
EP  - 1018
SN  - 00031224
AB  - Past research has treated self-esteem either as a social force or as a social product. However, this research has not given adequate attention to the reciprocal effects of the self-concept and various social and personal factors. A panel of 1886 adolescent boys is used to explore the reciprocal relationships between self-esteem and three problems of youth: juvenile delinquency; poor school performance; and psychological depression. We find that low self-esteem fosters delinquency and that delinquency may enhance self-esteem. These reciprocal effects differ among socioeconomic status groups. The relationship between self-esteem and school performance is primarily attributable to the effect of school performance on self-esteem. Finally, the causal relationship between self-esteem and depression is bidirectional. Substantive, methodological, and policy implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SELF-esteem
KW  - SELF-perception
KW  - SOCIAL factors
KW  - TEENAGE boys
KW  - JUVENILE delinquency
N1  - Accession Number: 15491959; Rosenberg, Morris 1 Schooler, Carmi 2 Schoenbach, Carrie 2; Affiliation:  1: National Institute of Mental Health and University of Maryland  2: National Institute of Mental Health; Source Info: Dec89, Vol. 54 Issue 6, p1004; Subject Term: SELF-esteem; Subject Term: SELF-perception; Subject Term: SOCIAL factors; Subject Term: TEENAGE boys; Subject Term: JUVENILE delinquency; Number of Pages: 16p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gottesman, Susan
T1  - GENETICS OF PROTEOLYSIS IN ESCHERICHIA COLI.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1989/12//
VL  - 23
M3  - Article
SP  - 163
EP  - 198
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Examines the role of energy-dependent proteases in the proteolysis of escherichia coli.  Substrates for proteolysis in escherichia coli; Degradation of abnormal proteins in heat shock mutants; Protein degradation by heat shock proteases; Energy-independent proteolysis.
KW  - PROTEOLYTIC enzymes
KW  - PROTEOLYSIS
KW  - ESCHERICHIA coli
KW  - PROTEINS
KW  - HEAT shock proteins
KW  - GENETICS
N1  - Accession Number: 11852800; Gottesman, Susan 1; Affiliation:  1: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland; Source Info: 1989, Vol. 23, p163; Subject Term: PROTEOLYTIC enzymes; Subject Term: PROTEOLYSIS; Subject Term: ESCHERICHIA coli; Subject Term: PROTEINS; Subject Term: HEAT shock proteins; Subject Term: GENETICS; Number of Pages: 36p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Adhya, Sankar
T1  - MULTIPARTITE GENETIC CONTROL ELEMENTS: COMMUNICATION BY DNA LOOP.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1989/12//
VL  - 23
M3  - Article
SP  - 227
EP  - 250
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Describes how regulatory proteins and DNA sites interact with each other and thereby govern gene expression.  Examples of negative control systems of escherichia coli; Regulatory systems with DNA looping; Role of DNA loop in repression; Positive control elements at distant locations.
KW  - GENE expression
KW  - DNA
KW  - ESCHERICHIA coli
KW  - GENETIC transcription
KW  - RNA polymerases
KW  - GENETICS
N1  - Accession Number: 11852826; Adhya, Sankar 1; Affiliation:  1: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 1989, Vol. 23, p227; Subject Term: GENE expression; Subject Term: DNA; Subject Term: ESCHERICHIA coli; Subject Term: GENETIC transcription; Subject Term: RNA polymerases; Subject Term: GENETICS; Number of Pages: 24p; Illustrations: 8 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Welch, L. M.;
AU  - Moore, E. S.;
AU  - Gubish, R. S.;
T1  - ESTABLISHING A PHARMACY NETWORK FOR AIDS CLINICAL TRIALS
CT  - ESTABLISHING A PHARMACY NETWORK FOR AIDS CLINICAL TRIALS
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1989/12/01/
VL  - 24
IS  - Dec
SP  - P
EP  - D
AD  - Clinical Research Products Repository, Pharmaceutical and Regulatory Affairs Branch, National Institute of Allergy and Infectious Diseases, 6003 Executive Boulevard, Rockville, MD 20892, USA
N1  - Accession Number: 27-01655; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice; Investigational Drugs
N2  - This poster describes the need for and the steps in establishing a nationwide communications network for pharmacists involved in AIDS clinical trials. In order to meet the challenge of the AIDS epidemic, great emphasis has been placed on conducting large, multicenter clinical trials, and on making investigational drugs more widely available. Pharmacists can represent a critical element in the clinical trials process. The many demands associated with conducting AIDS clinical trials emphasize the need for a sophisticated communications network for these pharmacists. Benefits of a communications network include sharing solutions to common problems; facilitating pharmacist involvement in early protocol development to include input into case report form design; evaluation of a study's feasibility, and input into product packaging and labeling; and dissemination of research results. The network should also serve as a resource to other pharmacists outside the network who care for AIDS p tients. Steps that have already been taken in establishing the network include organizing local meetings for network pharmacists, distributing a list of network pharmacists' names and phone numbers, and arranging for pharmacists to have input into early protocol development. Future plans include thorough development and promotion of the network, making electronic mail communication accessible to network members, provision of an electronic message board, and arranging for pharmacist membership on national study group committees. Through this network, pharmacists as a team can have a significant impact on the rapid implementation of research protocols in which promising new agents are studied.
KW  - Practice Interest Areas--Administrative Practice--meeting presentations;
KW  - ASHP meeting abstracts--AIDS clinical studies;
KW  - Clinical studies--acquired immunodeficiency syndrome--pharmacy network;
KW  - Acquired immunodeficiency syndrome--clinical studies--pharmacy network;
KW  - Drugs, investigational--acquired immunodeficiency syndrome--clinical studies, pharmacy network;
KW  - Pharmacists--clinical studies--network, AIDS;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Moore, L. M.;
AU  - Welch, L. M.;
AU  - Gubish, E. R.;
T1  - PHARMACISTS BENEFIT MULTICENTER CLINICAL TRIALS
CT  - PHARMACISTS BENEFIT MULTICENTER CLINICAL TRIALS
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1989/12/01/
VL  - 24
IS  - Dec
SP  - P
EP  - D
AD  - Pharmaceutical and Regulatory Affairs Branch, National Institute of Allergy and Infectious Diseases, 6003 Executive Boulevard, Rockville, MD 20892, USA
N1  - Accession Number: 27-02138; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education; Institutional Pharmacy PracticeInvestigational Drugs
N2  - This poster describes how a national acquired immunodeficiency syndrome (AIDS) research network has provided an opportunity for pharmacists to play a key role in the success of multicenter clinical trials for AIDS research. When these trials began in late 1986, the National Institute of Allergy and Infectious Diseases (NIAID) recognized that the rapid implementation of multicenter, double-blind clinical trials could best be accomplished if pharmacists were responsible for the management and control of the investigational drugs. Because NIAID standardized drug procurement and accountability whenever possible, pharmacists could implement studies more rapidly than if each study were managed uniquely. Full compliance with FDA regulations governing the receipt, use and disposition of investigational drugs is best accomplished if the drugs are dispensed by pharmacists, according to routinely established procedures. Dispensing investigational drugs for AIDS studies presents interesting hallenges such as encouraging terminally ill patients not to break study blinding and avoiding any prescription labeling that might reveal patient diagnosis. The opportunities for pharmacists to impact upon AIDS research have aided pharmacist-to-pharmacist interactions by establishing a pharmacy network for AIDS clinical trials to include pharmacist representatives from community based patient care facilities; increasing opportunities for pharmacists to participate in protocol development; and, offering computerized and centralized drug ordering. Pharmacists' significant participation in AIDS research has provided NIAID with the ability to rapidly implement large, complex studies while maintaining a controlled investigational drug distribution system. It also gives NIAID the flexibility to provide drugs to a large number of patients under the Treatment IND mechanism. Further, this participation has also provided the framework on which to build a sophisticated pharmacist communication network. This network can stimulate the identification of research concepts designed to answer critical questions and can provide a forum for the present tion of the research.
KW  - Practice Interest Areas--Administrative Practice--meeting presentations;
KW  - ASHP meeting abstracts--clinical studies;
KW  - Clinical studies--pharmacists--role, AIDS;
KW  - Pharmacists--role--clinical studies, AIDS;
KW  - Acquired immunodeficiency syndrome--clinical studies--pharmacists role;
KW  - Drugs, investigational--clinical studies--pharmacists role, AIDS;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Baltz, J.;
AU  - Kennedy, P.;
AU  - Minor, J.;
AU  - Gallelli, J.;
T1  - VISUAL COMPATIBILITY OF FOSCARNET (TRISODIUM PHOSPHONOFORMATE) WITH OTHER INJECTABLE DRUGS DURING SIMULATED Y-SITE ADMINISTRATION
CT  - VISUAL COMPATIBILITY OF FOSCARNET (TRISODIUM PHOSPHONOFORMATE) WITH OTHER INJECTABLE DRUGS DURING SIMULATED Y-SITE ADMINISTRATION
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1989/12/01/
VL  - 24
IS  - Dec
SP  - P
EP  - E
AD  - Warren G. Magnuson National Institutes of Health, Pharmacy Dept., Bethesda, MD 20892, USA
N1  - Accession Number: 27-02031; Language: English; Chemical Name: Foscarnet--4428-95-9 Acyclovir--59277-89-3 Pentamidine isethionate--140-64-7 Trimetrexate--52128-35-5 Amphotericin B--1397-89-3; Therapeutic Class: (8:18); AHFS Class: Antivirals foscarnet (10:00); AHFS Class: Antineoplastic agents trimetrexate (8:18); AHFS Class: Antivirals acyclovir (8:00); AHFS Class: Anti-infective agents pentamidine isethionate (8:12.04); AHFS Class: Antifungals amphotericin B; Publication Type: Abstract of Meeting Presentation; Section Heading: Drug Stability
N2  - Foscarnet is a pyrophosphate analog. It competitively inhibits viral MNA polymerase of herpes simplex virus and cytomegalovirus. Cytomegalovirus has become one of the leading causes of morbidity and mortality for the immunodeficient patients, including renal transplant recipients. AIDS patients commonly require multiple injectable medications for treatment of their disease and other opportunistic infections that occur. As a result, frequent questions arise concerning the compatibility of these drugs, including new investigational agents, with other medications commonly administered to the AIDS patient. To help our staff answer these questions a visual compatibility study of foscarnet with other injectable drugs during a simulated Y-site administration was performed. The study included: the use of a light beam with both light and dark background for visualization of precipitation, color change, haze, and gas formation; microscopic evaluation with polarized light at the magnification of 200x and 500x to visualize both crystals and particles; pH analysis at the first and final stages of the study to observe any changes in pH; thin layer chromatography (TLC) on all crystalline precipitates to characterize incompatible solutions. All samples were done in triplicate in both dextrose 5% and 0.9% sodium chloride for injection, where applicable. A 1:1 ratio of foscarnet (24mg/mL) and each secondary additive solution was used for the sample solution. Crystals were observed in solutions containing acyclovir, pentamidine isethionate, and trimetrexate. TLC was performed and the secondary additive was spotted in each instance. Foscarnet was not observed. A copius haze was observed in the solution containing amphotericin B.
KW  - Foscarnet--incompatibilities-;
KW  - Acyclovir--incompatibilities-;
KW  - Pentamidine isethionate--incompatibilities-;
KW  - Trimetrexate--incompatibilities-;
KW  - Amphotericin B--incompatibilities-;
KW  - Practice Interest Areas--Intravenous Therapy/Infusion Devices--meeting presentations;
KW  - ASHP meeting abstracts--foscarnet incompatibilities;
KW  - Antivirals--foscarnet--incompatibilities;
KW  - Antineoplastic agents--trimetrexate--incompatibilities, foscarnet;
KW  - Antivirals--acyclovir--incompatibilities, foscarnet;
KW  - Anti-infective agents--pentamidine isethionate--incompatibilities, foscarnet;
KW  - Additives--injections--foscarnet incompatibilities;
KW  - Injections--foscarnet--incompatibilities;
KW  - Incompatibilities--foscarnet--admixtures;
KW  - Antifungals--amphotericin B--incompatibilities, foscarnet;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Minor, J. R.;
T1  - EPIDEMIOLOGY AND NATURAL HISTORY OF HIV INFECTION
CT  - EPIDEMIOLOGY AND NATURAL HISTORY OF HIV INFECTION
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1989/12/01/
VL  - 24
IS  - Dec
SP  - PI
EP  - 43
AD  - Pharmacy Department, Warren G. Magnuson Clinical Center National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 27-02045; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2  - Infection with the human immunodeficiency virus (HIV) has now been docu-mented in over 100,000 persons in the United States. Of these, nearly 60% have died. HIV is a sexual and blood-borne pathogen that attacks and ultimately cripples a critical component of the immune system, the T4 helper-inducer lymphocyte. Manifestations of HIV infection range from subclinical laboratory abnormalities to malignancies and opportunistic infections that define AIDS. This presentation reviews what is known about the natural history of HIV, routes of transmission, current demographics and implications for the future course of the epidemic, and proposed intervention strategies.
KW  - ASHP meeting abstracts--human immunodeficiency virus infections;
KW  - Human immunodeficiency virus--infections--epidemiology;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Susla, G. M.;
T1  - ROLE OF THE PHARMACIST IN CARDIOVASCULAR EMERGENCIES
CT  - ROLE OF THE PHARMACIST IN CARDIOVASCULAR EMERGENCIES
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1989/12/01/
VL  - 24
IS  - Dec
SP  - PI
EP  - 33
AD  - National Institutes of Health, Clinical Center Pharmacy Department, Building 10, Room 1N-257, 9000 Rockville Pike, Bethesda, MD 20892, USA
N1  - Accession Number: 27-01773; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice
N2  - The role of the hospital pharmacist in cardiovascular emergencies is presented, including current practice and participation as a code team member, training, responsibilities, and development of policies and procedures.
KW  - ASHP meeting abstracts--hospital pharmacists and resuscitation team;
KW  - Resuscitation--cardiopulmonary--hospital pharmacists, team member;
KW  - Pharmacists, hospital--resuscitation--cardiopulmonary, team;
KW  - Team--resuscitation--cardiopulmonary, hospital pharmacists;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chabner, B. A.;
T1  - OPPORTUNITIES AND CHALLENGES IN CHEMOTHERAPEUTICS: LOOKING TO THE 1990\LC/s\UC/
CT  - OPPORTUNITIES AND CHALLENGES IN CHEMOTHERAPEUTICS: LOOKING TO THE 1990\LC/s\UC/
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1989/12/01/
VL  - 24
IS  - Dec
SP  - SPG
EP  - -17
AD  - Division of Cancer Treatment, National Cancer Institute, Bldg. 31, Room 3A52, Bethesda, MD 20892, USA
N1  - Accession Number: 27-02057; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
KW  - ASHP meeting abstracts--future drugs;
KW  - Drugs--future--1990s;
KW  - History--drugs--future, 1990s;
KW  - Antineoplastic agents--future--1990s;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Interleukin 6 May Play Important Role in Psoriasis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/12//12/1/89
VL  - 262
IS  - 21
M3  - Article
SP  - 2978
EP  - 2978
SN  - 00987484
AB  - Reports that high levels of the cytokine interleukin 6 (IL-6) have been found in patients with psoriasis.  Possibility of IL-6 contributing to the epidermal hyperplasia characteristic of the disease; Ability of IL-6 to stimulate the proliferation of normal human keratinocytes in culture.
KW  - INTERLEUKIN-6
KW  - PSORIASIS
KW  - CYTOKINES
N1  - Accession Number: 10982433; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 12/1/89, Vol. 262 Issue 21, p2978; Subject Term: INTERLEUKIN-6; Subject Term: PSORIASIS; Subject Term: CYTOKINES; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Common Protein Deficiency May Predispose to Meningitis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/12//12/1/89
VL  - 262
IS  - 21
M3  - Article
SP  - 2978
EP  - 2978
SN  - 00987484
AB  - Reports on a study which claims that deficiency of the immune system protein C4B may increase the susceptibility of children to bacterial meningitis.  Hemolytic activity of C4B; Scientists who conducted the study.
KW  - PROTEIN deficiency
KW  - IMMUNE system
KW  - MENINGITIS in children
N1  - Accession Number: 10982434; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 12/1/89, Vol. 262 Issue 21, p2978; Subject Term: PROTEIN deficiency; Subject Term: IMMUNE system; Subject Term: MENINGITIS in children; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Therapy for Hepatitis B-Related Glomerulonephritis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/12//12/1/89
VL  - 262
IS  - 21
M3  - Article
SP  - 2978
EP  - 2978
SN  - 00987484
AB  - Reports on a study which shows that interferon alpha may be an effective treatment for patients with glomerulonephritis caused by chronic hepatitis B virus infection.  Effect of the interferon on the serum levels of patient subjects; Improvement in patients' hepatocyte necrosis and inflammation following interferon alpha treatment.
KW  - INTERFERONS
KW  - GLOMERULONEPHRITIS -- Treatment
KW  - HEPATITIS B virus
KW  - VIRUS diseases
N1  - Accession Number: 10982435; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 12/1/89, Vol. 262 Issue 21, p2978; Subject Term: INTERFERONS; Subject Term: GLOMERULONEPHRITIS -- Treatment; Subject Term: HEPATITIS B virus; Subject Term: VIRUS diseases; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Bioassays Distinguish Muscular Dystrophies.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/12//12/1/89
VL  - 262
IS  - 21
M3  - Article
SP  - 2978
EP  - 2978
SN  - 00987484
AB  - Reports on a study which claims that abnormalities of dystrophin, the protein product of the Duchenne type muscular dystrophy gene, are the underlying chemical defects responsible for Duchenne type and Becker's muscular dystrophies.  Specific types of dystrophin abnormalities correlated by scientists with specific immunohistological staining patterns in muscle.
KW  - DYSTROPHIN
KW  - DUCHENNE muscular dystrophy
KW  - BECKER muscular dystrophy
N1  - Accession Number: 10982436; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 12/1/89, Vol. 262 Issue 21, p2978; Subject Term: DYSTROPHIN; Subject Term: DUCHENNE muscular dystrophy; Subject Term: BECKER muscular dystrophy; Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Hoofnagle, Jay H.
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/12//12/1/89
VL  - 262
IS  - 21
M3  - Letter
SP  - 2996
EP  - 2996
SN  - 00987484
AB  - Presents a letter to the editor responding to commentaries on the article about delta hepatitis, published in the 'Journal of the American Medical Association'.
KW  - LETTERS to the editor
KW  - HEPATITIS D
N1  - Accession Number: 10982373; Hoofnagle, Jay H. 1; Affiliation:  1: National Institutes of Health, Bethesda, Md; Source Info: 12/1/89, Vol. 262 Issue 21, p2996; Subject Term: LETTERS to the editor; Subject Term: HEPATITIS D; Number of Pages: 4/9p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Finlay, B. B.
AU  - Falkow, S.
T1  - Salmonella as an intracellular parasite.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1989/12//
VL  - 3
IS  - 12
M3  - Article
SP  - 1833
EP  - 1841
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Salmonella species are facultative intracellular parasites, capable of penetrating (invading), surviving, and often multiplying within diverse eukaryotic cell types, including epithelial and phagocytic cells. These processes are essential for virulence, and involve both bacterial and host cell products. The use of cultured eukaryotic cells and other model systems has facilitated the study of bacterial-host cell interactions, and has led to a better understanding of the genetic and molecular basis of Salmonella pathogenicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Enterobacteriaceae
KW  - Gram-negative bacteria
KW  - Eukaryotic cells
KW  - Salmonella
KW  - Cell interaction (Biology)
KW  - Epithelial cells
KW  - Cells
KW  - Epithelium
N1  - Accession Number: 18287258; Finlay, B. B. 1; Falkow, S. 2,3; Affiliations: 1: Biotechnology Laboratory and the Departments of Biochemistry and Microbiology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1W5; 2: Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305, USA; 3: Laboratory of Pathobiology, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, Montana 59840, USA; Issue Info: Dec1989, Vol. 3 Issue 12, p1833; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Eukaryotic cells; Thesaurus Term: Salmonella; Subject Term: Cell interaction (Biology); Subject Term: Epithelial cells; Subject Term: Cells; Subject Term: Epithelium; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06493-065
AN  - 2006-06493-065
AU  - Hunt, Walter A.
T1  - Mechanisms Underlying Drug Stimuli.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1989/12//
VL  - 34
IS  - 12
SP  - 1146
EP  - 1146
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06493-065. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hunt, Walter A.; Neuroscience and Behavioral Research Branch, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Discrimination; Drugs; Psychopharmacology. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Colpaert, F. C. (Ed); Balster, R. L. (Ed). Transduction Mechanisms of Drug Stimuli=Berlin, Federal Republic of Germany: Springer-Verlag, 1988. 236 pp. (Springer-Verlag New York), (Springer-Verlag Berlin) $89.70; 1988. Page Count: 1. Issue Publication Date: Dec, 1989. 
AB  - Reviews the book, Transduction Mechanisms of Drug Stimuli edited by F. C. Colpaert and R. L. Balster (see record [rid]1988-97913-000[/rid]). In addition to an introductory chapter, the book is divided into two sections. One section extensively reviews the effects of various drug classes in drug discrimination paradigms. The other section is more theoretical and deals with mechanisms that could underlie the transduction of drug stimuli and which approaches to take to investigate these mechanisms. In all, this book is quite technical and would be most useful to those readers specifically interested in the field of psychopharmacology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug stimuli
KW  - transduction mechanisms
KW  - drug discrimination
KW  - 1989
KW  - Drug Discrimination
KW  - Drugs
KW  - Psychopharmacology
KW  - 1989
U2  - Colpaert, F. C. (Ed); Balster, R. L. (Ed). (1988); Transduction Mechanisms of Drug Stimuli; Berlin, Federal Republic of Germany: Springer-Verlag, 1988. 236 pp. (Springer-Verlag New York), (Springer-Verlag Berlin) $89.70; 0-387-18617-4; 3-540-18617-4.
DO  - 10.1037/030863
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Safer, Brian
T1  - Nomenclature of initiation, elongation and termination factors for translation in eukaryotes.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/12/08/
VL  - 186
IS  - 1/2
M3  - Article
SP  - 1
EP  - 3
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Focuses on nomenclature of initiation, elongation and termination factors for translation in eukaryotes.  General principles of symbolism; Activities of each factor; Main groups and subunits of initiation factors; Complete molecule; Previous nomenclature; List of known mammalian factors; Future revision.
KW  - EUKARYOTIC cells
KW  - BIOCHEMISTRY
KW  - NAMES
KW  - SYMBOLISM
N1  - Accession Number: 13778422; Safer, Brian 1; Affiliation:  1: National Institutes of Health, USA; Source Info: 12/8/89, Vol. 186 Issue 1/2, p1; Subject Term: EUKARYOTIC cells; Subject Term: BIOCHEMISTRY; Subject Term: NAMES; Subject Term: SYMBOLISM; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ohtani, Yoshiro
AU  - Irie, Tetsumi
AU  - Uekama, Kaneto
AU  - Fukunaga, Kazuhiro
AU  - Pitha, Josef
T1  - Differential effects of α-, β- and γ-cyclodextrins on human erythrocytes.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1989/12/08/
VL  - 186
IS  - 1/2
M3  - Article
SP  - 17
EP  - 22
PB  - Wiley-Blackwell
SN  - 00142956
AB  - α-, β- and γ-cyclodextrins are cyclic hexamers, heptamers, and octamers of glucose, respectively, and thus are hydrophilic; nevertheless, they have the ability to solubilize lipids through the formation of molecular inclusion complexes. The volume of lipophilic space involved in the solubilization process increases with the number of glucose units in the cyclodextrin molecule and, consequently, cyclodextrins were found to have different effects on human erythrocytes: (a) in the induction of shape change from discocyte to spherocyte the potency was observed to be α > γ, but with β-cyclodextrin hemolysis occurred before the change was complete; (b) in the increase of fluorescence intensity of 1-anilinonaphthalene-8-sulfonate in cyclodextrin-pretreated membranes, the observed potency was β » γ > α; (c) in the release of potassium and hemoglobin, the potency was β > α > γ. The potencies of cyclodextrin for solubilizing various components of erythrocytes were et > β » γ, for phospholipids, β » γ > α for cholesterol and β » γ > α for proteins. The solubilization potencies were derived from concentration/ final-effect curves. The above processes occurred without entry of solubilizer into the membrane, since (a) β[14C]cyclodextrin did not bind to erythrocytes and (b) cyclodextrins did not enter the cholesterol monolayer. A study of the [³H]cholesterol in erythrocytes indicated that β-cyclodextrin extracted this lipid from membrane into a new compartment located in the aqueous phase which could equilibrate rapidly with additional erythrocytes. Therefore, the effects of cyclodextrins differ from those of detergents which first incorporate themselves into membranes then extract membrane components into supramolecular micelles. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYCLODEXTRINS
KW  - ERYTHROCYTES
KW  - GLUCOSE
KW  - HEMOLYSIS & hemolysins
KW  - MICELLES
KW  - CHOLESTEROL
N1  - Accession Number: 13778449; Ohtani, Yoshiro 1 Irie, Tetsumi 2 Uekama, Kaneto 2 Fukunaga, Kazuhiro 1,3 Pitha, Josef 3; Affiliation:  1: Kaken Pharmaceutical Co. Ltd., Tokyo, Japan  2: Faculty of Pharmaceutical Sciences, Kumamoto University, Japan  3: National Institutes of Health, National Institute on Aging/GRC, USA; Source Info: 12/8/89, Vol. 186 Issue 1/2, p17; Subject Term: CYCLODEXTRINS; Subject Term: ERYTHROCYTES; Subject Term: GLUCOSE; Subject Term: HEMOLYSIS & hemolysins; Subject Term: MICELLES; Subject Term: CHOLESTEROL; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Straus, Stephen E.
T1  - Clinical and Biological Differences Between Recurrent Herpes Simplex Virus and Varicella-Zoster Virus Infections.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1989/12/22/
VL  - 262
IS  - 24
M3  - Article
SP  - 3455
EP  - 3458
SN  - 00987484
AB  - Discusses the clinical and biological differences between recurrent herpes simplex virus and varicella-zoster virus infections.  Case studies; Major features that distinguish recurrent herpes simplex virus infections from zoster; Resemblance of oral-labial herpes to genital herpes; Clinical and epidemiologic features that characterize recurrent herpes simplex virus and varicella-zoster virus infections.
KW  - HERPES simplex virus
KW  - VARICELLA-zoster virus
KW  - VIRUS diseases
KW  - HERPESVIRUSES
N1  - Accession Number: 10983337; Straus, Stephen E. 1; Affiliation:  1: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda; Source Info: 12/22/89-12/29/89, Vol. 262 Issue 24, p3455; Subject Term: HERPES simplex virus; Subject Term: VARICELLA-zoster virus; Subject Term: VIRUS diseases; Subject Term: HERPESVIRUSES; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kohn, Melvin L.
AU  - Naoi, Atsushi
AU  - Schoenbach, Carrie
AU  - Schooler, Carmi
AU  - Slomczynski, Kazimierz M.
T1  - Position in the Class Structure and Psychological Functioning in the United States, Japan, and Poland.
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1990/01//
VL  - 95
IS  - 4
M3  - Article
SP  - 964
EP  - 1008
SN  - 00029602
AB  - This article conceptualizes and indexes social class for a Western capitalist country (the United States), a non-Western capitalist country (Japan), and a socialist country (Poland). The idea that social classes are to be distinguished in terms of ownership, control of the means of production. and control over the labor power of others is adapted to the historical, cultural, economic, and political circumstances of each country. It is hypothesized that men who are more advantageously located in the class structure of their society are more likely to value self-direction for their children, to be intellectually flexible, and to be self-directed in their orientations than men who are less advantageously located. This hypothesis is strikingly confirmed. The hypothesis that occupational self-direction plays a crucial role in explaining the psychological effect of social class in all three countries is also confirmed. There was no firm basis for hypothesizing the relationships between social class and a sense of distress. The pattern is cross-nationally inconsistent, in part be- cause occupational self-direction does not have the cross-nationally consistent effect on the sense of distress that it has on other facets of psychological functioning [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Sociology is the property of University of Chicago Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL classes
KW  - HYPOTHESIS
KW  - SOCIAL psychology
KW  - UNITED States
KW  - JAPAN
KW  - POLAND
N1  - Accession Number: 11268154; Kohn, Melvin L. 1 Naoi, Atsushi 2 Schoenbach, Carrie 3 Schooler, Carmi 3 Slomczynski, Kazimierz M. 4; Affiliation:  1: Johns Hopkins University.  2: Osaka University.  3: National institute of Mental Health.  4: University of Warsaw.; Source Info: Jan90, Vol. 95 Issue 4, p964; Subject Term: SOCIAL classes; Subject Term: HYPOTHESIS; Subject Term: SOCIAL psychology; Subject Term: UNITED States; Subject Term: JAPAN; Subject Term: POLAND; Number of Pages: 45p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Carter, J W
T1  - Applications of classification
JO  - ASIS '90: Proceedings of the 53rd Annual Meeting of the American Society for Information Science
JF  - ASIS '90: Proceedings of the 53rd Annual Meeting of the American Society for Information Science
Y1  - 1990///
M3  - Conference Paper
SP  - 342
EP  - 342
SN  - 0938734482
AB  - This session examines acid rain information resources available in Canada and the US. The studies demonstrate how public information on acid rain in Canada influenced public policy. American access to Canadian government documents relating to acid rain following the UVM Acid Rain Project is also examined. Trends in the growth of bibliographic information in the area of acid rain are studied, the role of fugitive and no-traditional literature are discussed, and the sources and nature of more than 1500 reference questions answered by the Acid Rain Information Clearinghouse are examined. Proceeding Published by Learned Information, Inc., United States, 1990
KW  - CLASSIFICATION
KW  - CANADA
KW  - Clearinghouses
KW  - Environmental information
N1  - Accession Number: ISTA2601036; Carter, J W 1; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: 1990, p342; Note: Place of Publication: United States; Note: Publisher: Learned Information, Inc.; Note: Update Code: 2600; Note: Conference Title: ASIS '90: Proceedings of the 53rd Annual Meeting of the American Society for Information Science; Note: Conference Location: Toronto, Ontario; Note: Conference Dates: November 4-8, 1990; Subject Term: CLASSIFICATION; Subject: CANADA; Author-Supplied Keyword: Clearinghouses; Author-Supplied Keyword: Environmental information; Number of Pages: 1p; Document Type: Conference Paper
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Irani, A. A.
AU  - Garriga, M. M.
AU  - Metcalfe, D. D.
AU  - Schwartz, L. B.
T1  - Mast cells in cutaneous mastocytosis: accumulation of the MCTC type.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1990/01//
VL  - 20
IS  - 1
M3  - Article
SP  - 53
EP  - 58
PB  - Wiley-Blackwell
SN  - 09547894
AB  - Lesional (n= 15) and non-lesional (n= 10) skin of subjects with mastocytosis was analysed for the distribution and concentration of trypase positive. chymase negative mast cells (MCT) and tryptase positive, chymase positive mast cells (MCTC cells and compared to normal skin (n=23) and non-lesional skin of subjects with unexplained anaphylaxis or flushing episodes (n = 6). Skin biopsies were fixed in Carnoy's fluid and subjected to double immunohistochemical staining with biotinylated mouse monoclonal anti-chymase antibody followed by alkaline phosphatase-conjugated mouse monoclonal anti-tryptase antibody. MCTC cells were the only type of mast cells seen in all specimens analysed and in each case were more numerous in superficial compared to deep regions of dermis. The concentration (mean ±s.d.) of mast cells in the superficial dermis of mastocytosis lesions (40 985 ± 21 772 mast cells/mm3) was significantly increased over that in corresponding areas of non-lesional skin from subjects with mastocytosis (7178 ± 3607 mast cells/mm3). skin from subjects with idiopathic anaphylaxis or flushing episodes (6974 ± 3873 mast cells/mm3) and normal skin (7347 ± 2973 mast cells/mm3). The exclusive presence of MCTC cells in skin lesions of mastocytosis which arc characterized by non-malignant hyperplasia of mast cells suggests involvement of local tissue factors in mast cell recruitment and differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - ALLERGY
KW  - CLINICAL pathology
KW  - ALKALINE phosphatase
KW  - SKIN diseases
KW  - MAST cells
N1  - Accession Number: 16495507; Irani, A. A. 1 Garriga, M. M. 2 Metcalfe, D. D. 2 Schwartz, L. B. 3; Affiliation:  1: Department of Pediatrics, Medical College of Virginia, Richmond.  2: Department of Medicine, Medical College of Virginia, Richmond.  3: Mast Cell Physiology Section, National Institutes of Health, Bethesda, U.S.A.; Source Info: Jan1990, Vol. 20 Issue 1, p53; Subject Term: MAST cell disease; Subject Term: ALLERGY; Subject Term: CLINICAL pathology; Subject Term: ALKALINE phosphatase; Subject Term: SKIN diseases; Subject Term: MAST cells; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sandrock, Dirk
AU  - Merino, Maria
AU  - Scheffknecht, Beate
AU  - Neumann, Ronald
T1  - Scintigraphic findings and follow up in Erdheim-Chester disease.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1990/01//
VL  - 16
IS  - 1
M3  - Article
SP  - 55
EP  - 60
SN  - 03406997
N1  - Accession Number: 71143702; Sandrock, Dirk 1 Merino, Maria 2 Scheffknecht, Beate 3 Neumann, Ronald 1; Affiliation:  1: Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, USA  2: Laboratory of Pathology, National Cancer Institute, USA  3: Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda USA; Source Info: Jan1990, Vol. 16 Issue 1, p55; Number of Pages: 6p; Document Type: Article
L3  - 10.1007/BF01566013
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
ID  - 1990-98681-027
AN  - 1990-98681-027
AU  - Stockdill, J.
ED  - Magrab, Phyllis R.
ED  - Wohlford, Paul
ED  - Magrab, Phyllis R., (Ed)
ED  - Wohlford, Paul, (Ed)
T1  - NIMH clinical training policy: The context of the 1988 conferences.
T2  - Improving psychological services for children and adolescents with severe mental disorders:  Clinical training in psychology.
Y1  - 1990///
SP  - 9
EP  - 10
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-080-2
N1  - Accession Number: 1990-98681-027. Partial author list: First Author & Affiliation: Stockdill, J.; Division of Education and Service Systems Liaison, National Institute of Mental Health, US. Release Date: 19900101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-080-2, Paperback. Language: English. Major Descriptor: Child Psychology; Clinical Psychology Graduate Training; Mental Health Services. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 2. 
AB  - This chapter lists the assumptions underlying Division of Education and Service Systems liaison's three-year strategy to bring together service demonstration, services technical assistance and knowledge transfer, and clinical training programs into one division. It also poses questions for considering clinical training to improve services for children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical training programs
KW  - services to children
KW  - 1990
KW  - Child Psychology
KW  - Clinical Psychology Graduate Training
KW  - Mental Health Services
KW  - 1990
DO  - 10.1037/10072-027
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Corse, Sara J.
AU  - Schmid, Kathleen
AU  - Trickctt, Penelope K.
T1  - Social Network Characteristics of Mothers in Abusing and Nonabusing Families and Their Relationships to Parenting Beliefs.
JO  - Journal of Community Psychology
JF  - Journal of Community Psychology
Y1  - 1990/01//
VL  - 18
IS  - 1
M3  - Article
SP  - 44
EP  - 59
PB  - John Wiley & Sons, Inc.
SN  - 00904392
AB  - This study compares the social networks of mothers in families identified as abusive and mothers in control families and looks at the relationships between social networks and parenting beliefs and practices. Participants were mothers from 52 families who were part of a larger investigation of child-rearing in physically abusing versus nonabusing families. Mothers were interviewed about their social networks and completed the Family Environment Scale (Moos & Moos, 1981) and the Child-Rearing Practices Q-Sort (Block. 1981). Mothers in abusing families were found to be more socially isolated than were those mothers in nonabusing families. They had fewer peer relationships, more troubled relationships with relatives, and more limited contact with the wider community. A pattern linking social support and parenting beliefs emerged, suggesting that the presence of peers in the network is related to greater enjoyment of and openness in parenting. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOTHERS
KW  - CHILD rearing
KW  - ABUSIVE parents
KW  - SOCIAL networks
KW  - PARENTING
KW  - PEER pressure
KW  - Child Abuse and Intervention
KW  - CHILD CARE, PROBLEMS, AND TREATMENT
N1  - Accession Number: 11979425; Corse, Sara J. 1 Schmid, Kathleen 2 Trickctt, Penelope K. 3; Affiliation:  1: Misericordia Hospital and University of Pennsylvania  2: Community College of Rhode Island, Newport  3: National Institute of Mental Health, Bethesda, MD; Source Info: Jan90, Vol. 18 Issue 1, p44; Subject Term: MOTHERS; Subject Term: CHILD rearing; Subject Term: ABUSIVE parents; Subject Term: SOCIAL networks; Subject Term: PARENTING; Subject Term: PEER pressure; Author-Supplied Keyword: Child Abuse and Intervention; Author-Supplied Keyword: CHILD CARE, PROBLEMS, AND TREATMENT; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
ID  - 1991-97166-002
AN  - 1991-97166-002
AU  - Wohlford, Paul
ED  - Johnson, Dale L.
ED  - Johnson, Dale L., (Ed)
T1  - The role of clinical training in psychology to meet the needs of the seriously mentally ill.
T2  - Service needs of the seriously mentally ill:  Training implications for psychology.
Y1  - 1990///
SP  - 7
EP  - 10
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-102-7
N1  - Accession Number: 1991-97166-002. Partial author list: First Author & Affiliation: Wohlford, Paul; Psychology Education Program, National Institute of Mental Health, Rockville, MD, US. Release Date: 19910101. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-102-7, Paperback. Language: English. Conference Information: National Conference on Clinical Training in Psychology: Improving the Participation of Psychologists in the Provision of Services to the Seriously Mentally  Ill, Apr, 1988, University of Texas, Houston, TX, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Chronic Mental Illness; Clinical Psychology Graduate Training; Health Service Needs; Mental Health Services; Severity (Disorders). Minor Descriptor: Mental Health; Psychology Education. Classification: Health & Mental Health Services (3370); Professional Education & Training (3410). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 4. 
AB  - The highest priority of the National Institute for Mental Health's (NIMH) clinical training program is the training of mental health professionals to provide treatment and rehabilitation services to severely and persistently mentally ill persons, specifically, individuals with schizophrenic disorders, major mood disorders, or other chronic mental illness. One of the greatest needs in professional mental health education programs across the country is to systematically improve the effectiveness of their training programs and, ultimately, to improve the competence of their professional trainees, including psychologists, who will provide services to seriously mentally ill persons. This chapter describes the current situation in psychology training programs; the shift in psychological service areas; and changing trends in mental health services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - seriously mentally ill
KW  - clinical psychology training program
KW  - mental health education
KW  - mental health needs
KW  - 1990
KW  - Chronic Mental Illness
KW  - Clinical Psychology Graduate Training
KW  - Health Service Needs
KW  - Mental Health Services
KW  - Severity (Disorders)
KW  - Mental Health
KW  - Psychology Education
KW  - 1990
DO  - 10.1037/10077-002
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Wiener, Lori S.
AU  - Siegel, Karolynn
T1  - Social Workers' Comfort in Providing Services to AIDS Patients.
JO  - Social Work
JF  - Social Work
Y1  - 1990/01//
VL  - 35
IS  - 1
M3  - Article
SP  - 18
PB  - Oxford University Press / USA
SN  - 00378046
AB  - With the steadily increasing number of people infected with the human immunodeficiency virus, social workers are being called on to play a key role in meeting the complex psychosocial needs of infected individuals and their significant others. To understand more about social workers' levels of comfort in providing services to individuals with acquired immune decifiency syndrome (AIDS) and their family and friends, a survey of social workers in 12 hospital centers was carried out. The majority of social workers were found to be compassionate and sensitive to the needs of this patient population. Several factors were found to be associated with comfort, including various background characteristics, knowledge about the disease, homophobia, negative moral attitudes toward people with AIDS, and the reactions of family and friends. In this article, the authors review these findings and discuss their implications for social work education and practice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL workers
KW  - AIDS patients
KW  - PUBLIC welfare
KW  - SOCIAL services
KW  - HUMAN services
KW  - IMMUNITY
KW  - HEALTH AND MEDICAL SERVICES
N1  - Accession Number: 6701075; Wiener, Lori S. 1 Siegel, Karolynn 2; Affiliation:  1: Pediatric HIV Psychosocial Support Program, National Cancer Institute, Building 10, 3N240 Bethesda, MD 20892.  2: Director of Research, Department of Social Work Memorial Sloan-Kettering Cancer Center, New York NY.; Source Info: Jan90, Vol. 35 Issue 1, p18; Subject Term: SOCIAL workers; Subject Term: AIDS patients; Subject Term: PUBLIC welfare; Subject Term: SOCIAL services; Subject Term: HUMAN services; Subject Term: IMMUNITY; Author-Supplied Keyword: HEALTH AND MEDICAL SERVICES; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaplan, Mark S.
T1  - AIDS: Individualizing a Social Problem.
JO  - Society
JF  - Society
Y1  - 1990/01//Jan/Feb90
VL  - 27
IS  - 2
M3  - Article
SP  - 4
EP  - 7
SN  - 01472011
AB  - This article presents a value-critical analysis of AIDS policy in the U.S. as of January 1990. This analysis parallels criticism by Irving Louis Horowitz, who feels that the human confrontation with the AIDS epidemic is at rock bottom a matter of values than of policies. Values are central to the AIDS policy domain. Values influence the selection and definition of a specific policy issue, goals and objectives, as well as evaluation criteria. The article aims to make use of a mode of inquiry known as value-critical policy analysis. This mode of analysis seeks to unravel the underlying value systems of established policies, and the content nourishing these tacit assumptions. This mode of inquiry provides a framework for considering the social problems arising from the underlying and ubiquitous assumptions governing HIV/AIDS policy formulations.
KW  - AIDS (Disease)
KW  - GOVERNMENT policy
KW  - EPIDEMICS
KW  - SOCIAL problems
KW  - UNITED States
KW  - HOROWITZ, Irving Louis
N1  - Accession Number: 10867968; Kaplan, Mark S. 1; Affiliation:  1: National Cancer Institute Postdoctoral Fellow, Institute for Health Promotion and Disease Prevention Research, University of Southern California; Source Info: Jan/Feb90, Vol. 27 Issue 2, p4; Subject Term: AIDS (Disease); Subject Term: GOVERNMENT policy; Subject Term: EPIDEMICS; Subject Term: SOCIAL problems; Subject Term: UNITED States; People: HOROWITZ, Irving Louis; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
T1  - STRESS-PROTECTIVE FUNCTIONS OF POSITIVE EXPERIENCES DURING THE PREMENSTRUAL PERIOD.
AU  - Chaturvedi, S. K.
AU  - Chandra, Prabha S.
JO  - Stress Medicine
JF  - Stress Medicine
Y1  - 1990/01//Jan/Mar90
VL  - 6
IS  - 1
SP  - 53
EP  - 55
SN  - 07488386
N1  - Accession Number: 12029164; Author: Chaturvedi, S. K.: 1 Author: Chandra, Prabha S.: 1 ; Author Affiliation: 1 Department of Psychology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029. India.; No. of Pages: 3; Language: English; Publication Type: Article; Update Code: 20040126
N2  - The present study aimed at studying the presence of positive emotions during the premenstruum. A positive premenstrual assessment form was constructed and administered to 48 female nursing students in the reproductive age group. Ratings were done using numerical and visual analogue scales. Forty-six women reported experiencing at least some positive symptoms and two had none. Extremes of positive emotions were seen in 12-37 per cent of the women. The commonest emotions were a sense of well-being in 75 per cent and feelings of excitement and relief in 62 per cent. Increased sexual desire was reported by 42 per cent. The implications of these positive perimenstrual changes are described in terms of a stress-protective function regarding premenstrual distress and the premenstrual syndrome. It is likely that cultural factors may be involved in the stress-protective functions of these positive experiences. ABSTRACT FROM AUTHOR
KW  - *PREMENSTRUAL syndrome
KW  - *STRESS (Psychology)
KW  - *WELL-being
KW  - RELAXATION (Health)
KW  - SEXUAL excitement
KW  - positive emotions
KW  - Premenstrual period
KW  - well-being protection.
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2006-05392-014
AN  - 2006-05392-014
AU  - Zahn-Waxler, Carolyn
T1  - The ABCs of Morality: Affect, Behavior, and Cognition.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1990/01//
VL  - 35
IS  - 1
SP  - 25
EP  - 26
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05392-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn-Waxler, Carolyn; Section on Childhood Behavior Disorders, Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Cognition; Morality. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Kagan, Jerome (Ed); Lamb, Sharon (Ed). The Emergence of Morality in Young Children=Chicago: University of Chicago Press, 1987. 354 pp. $24.95; 1987. Page Count: 2. Issue Publication Date: Jan, 1990. 
AB  - Reviews the book, The Emergence of Morality in Young Children edited by Jerome Kagan and Sharon Lamb (see record [rid]1988-97609-000[/rid]). This edited volume is based on an interdisciplinary conference of psychologists, anthropologists, and philosophers. It concerns the early origins and evolution of a 'moral sense' and provides an explicit developmental, research- based focus. The book is a scholarly work that will be of interest to a broad readership. It provides an excellent articulation and critique of several developmental theories and summarizes salient research findings. Chapters are uniformly well written and provocative in content. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - morality
KW  - young children
KW  - moral sense
KW  - child development
KW  - cognition
KW  - 1990
KW  - Childhood Development
KW  - Cognition
KW  - Morality
KW  - 1990
U2  - Kagan, Jerome (Ed); Lamb, Sharon (Ed). (1987); The Emergence of Morality in Young Children; Chicago: University of Chicago Press, 1987. 354 pp. $24.95; 0-226-42231-3.
DO  - 10.1037/028147
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05392-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05392-033
AN  - 2006-05392-033
AU  - Rolandelli, David R.
T1  - Children and Television: Is It Worth Our Attention?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1990/01//
VL  - 35
IS  - 1
SP  - 49
EP  - 50
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05392-033. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rolandelli, David R.; National Institute of Mental Health, Cornell University, Ithaca, NY, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Developmental Psychology; Social Influences; Television; Television Viewing. Classification: Developmental Psychology (2800); Mass Media Communications (2750). Population: Human (10). Reviewed Item: Liebert, Robert M.; Sprafkin, Joyce. The Early Window: Effects of Television on Children and Youth (3rd ed.)=Oxford, England: Pergamon Press, 1988. 306 pp. $35.00 (£19.50) hardcover; $12.95 (£7.50) paperback; 1988. References Available: Y. Page Count: 2. Issue Publication Date: Jan, 1990. 
AB  - Reviews the book, The Early Window: Effects of Television on Children and Youth (3rd ed.) by Robert M. Liebert and Joyce Sprafkin (see record [rid]1988-97650-000[/rid]). According to the authors, the goal of this volume 'is to summarize and explain the considerable body of research now available on television's effects on the young from the point of view of both social science and social policy'. The book is fairly comprehensive, although some issues are covered in greater depth than others. Over half of the book is devoted to the effects of televised violence and advertising and to the attempts to regulate each. Although not stated directly, it is clear from the material reviewed by the authors that television viewing is an interactive process and that a number of factors on the viewer's part can influence television's effects. The Early Window demonstrates that children are not passive recipients of televised information--a view that is in contrast with that of many social critics--but bring their own experience, knowledge, and abilities to the viewing situation. Overall, this book provides an excellent review of the theory and research pertaining to children and television, especially with respect to the social effects literature. Liebert and Sprafkin make a convincing argument that television is important in children's lives and merits serious consideration by social scientists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - televisions effects
KW  - social effects
KW  - developmental psychology
KW  - 1990
KW  - Developmental Psychology
KW  - Social Influences
KW  - Television
KW  - Television Viewing
KW  - 1990
U2  - Liebert, Robert M.; Sprafkin, Joyce. (1988); The Early Window: Effects of Television on Children and Youth (3rd ed.); Oxford, England: Pergamon Press, 1988. 306 pp. $35.00 (£19.50) hardcover; $12.95 (£7.50) paperback; 0-08-034680-4 (Hardcover); 0-08-034679-0 (Paperback).
DO  - 10.1037/028166
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09119-001
AN  - 2008-09119-001
AU  - Drotar, Dennis
AU  - Johnson, Suzanne Bennett
AU  - Iannotti, Ron
AU  - Krasnegor, Norman
AU  - Matthews, Karen A.
AU  - Melamed, Barbara G.
AU  - Millstein, Susan
AU  - Peterson, Rolf A.
AU  - Popiel, Debbie
AU  - Routh, Donald K.
T1  - 'Child health psychology': Erratum.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1990///
VL  - 9
IS  - 6
SP  - 811
EP  - 811
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
AD  - Drotar, Dennis, Department of Psychiatry, Metro Health Medical Center, 3395 Scranton Road, Cleveland, OH, US, 44109
N1  - Accession Number: 2008-09119-001. Partial author list: First Author & Affiliation: Drotar, Dennis; Case Western Reserve University School of Medicine, OH, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20100111. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Erratum/Correction. Language: English. Major Descriptor: Child Psychology; Childhood Development; Developmental Psychology; Experimentation; Health Care Psychology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 1. Issue Publication Date: 1990. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1990. 
AB  - Reports an error in 'Child health psychology' by Dennis Drotar, Suzanne Bennett Johnson, Ron Iannotti, Norman Krasnegor, Karen A. Matthews, Barbara G. Melamed, Sharon Millstein, Rolf A. Peterson, Debbie Popiel and Donald K. Routh (Health Psychology, 1989, Vol 8[6], 781-784). The name of the author, Sharon Millstein, should be Susan Millstein. It appears correctly in this record. (The following abstract of the original article appeared in record [rid]2008-09118-001[/rid].) The term child health psychology refers to the field of research on the behavioral aspects of children's health and illness. At this time we need to continue the work of the child health psychology special interest group and to draw into the Division of Health Psychology a much larger number of developmental psychologists, who need to be informed about the relevance of their scientific training to child health issues. We call the Division's attention and that of granting agencies such as the National Institute of Child Health and Human Development to the following high-priority child health research issues: adherence to pediatric medical regimens; child health promotion; family influences on child and adolescent health and disease; and stress and coping in childhood illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child health psychology
KW  - developmental psychology
KW  - child health research
KW  - 1990
KW  - Child Psychology
KW  - Childhood Development
KW  - Developmental Psychology
KW  - Experimentation
KW  - Health Care Psychology
KW  - 1990
DO  - 10.1037/h0090324
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09119-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Cell Tropism Can Distinguish HIV Isolates.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/05/
VL  - 263
IS  - 1
M3  - Article
SP  - 21
EP  - 21
SN  - 00987484
AB  - Focuses on the study at the National Cancer Institute-Frederick Cancer Research Facility investigating the possibility of differentiating HIV isolates according to target-cell tropism.  Infection of T-lymphoid and monocytoid indicator cell lines with HIV isolates; Differences between the rapid and slow replication of isolates on transferase expression activation; Correlation between tropism and virulence.
KW  - HIV (Viruses)
KW  - CELL differentiation
KW  - TROPISMS
KW  - TRANSFERASES
KW  - VIRULENCE (Microbiology)
N1  - Accession Number: 10983198; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 1/5/90, Vol. 263 Issue 1, p21; Subject Term: HIV (Viruses); Subject Term: CELL differentiation; Subject Term: TROPISMS; Subject Term: TRANSFERASES; Subject Term: VIRULENCE (Microbiology); Number of Pages: 1/4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - Tumorigenesis of Astrocytomas.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/05/
VL  - 263
IS  - 1
M3  - Article
SP  - 21
EP  - 21
SN  - 00987484
AB  - Reports on the study by researchers in Boston and Utah claiming the association between deletions on Chromosome 17 and tumorigenesis of astrocytomas.  Possibility of the existence of tumor suppressor gene in chromosome 17.
KW  - CHROMOSOMES
KW  - CARCINOGENESIS
KW  - ASTROCYTOMAS
KW  - ANTIONCOGENES
N1  - Accession Number: 10983199; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 1/5/90, Vol. 263 Issue 1, p21; Subject Term: CHROMOSOMES; Subject Term: CARCINOGENESIS; Subject Term: ASTROCYTOMAS; Subject Term: ANTIONCOGENES; Number of Pages: 1/6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Dalakas, Mainos
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/05/
VL  - 263
IS  - 1
M3  - Letter
SP  - 37
EP  - 38
SN  - 00987484
AB  - Responds to the article 'AIDS and the Nervous System,' published in a 1989 issue of the 'Journal of the American Medical Association.'
KW  - AIDS (Disease)
KW  - NERVOUS system
KW  - NEUROSCIENCES
KW  - LETTERS to the editor
N1  - Accession Number: 10983125; Dalakas, Mainos 1; Affiliation:  1: National Institute of Neurological Disorders and Stroke, Bethesda, Md; Source Info: 1/5/90, Vol. 263 Issue 1, p37; Subject Term: AIDS (Disease); Subject Term: NERVOUS system; Subject Term: NEUROSCIENCES; Subject Term: LETTERS to the editor; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mosley, James W.
AU  - Aach, Richard D.
AU  - Hollinger, F. Blaine
AU  - Stevens, Cladd E.
AU  - Barboza, Luiz H.
AU  - Nemo, George J.
AU  - holland, Paul V.
AU  - Bancroft, William H.
AU  - Zimmerman, Hyman J.
AU  - Geroge Kuo
AU  - Q-L Choo
AU  - Houghton, Micahel
T1  - Non-A, Non-B Hepatitis and Antibody to Hepatitis C Virus.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/05/
VL  - 263
IS  - 1
M3  - Article
SP  - 77
EP  - 78
SN  - 00987484
AB  - Presents a study testing for the presence of antibody to hepatitis C virus (anti-HCV) in blood serum samples from a transfusion-transmitted virus study in 1970.  Negative presence of anti-HCV in control subjects without transfusion and with non-A, non-B hepatitis; Seronegativity in recipients with posttransfusion hepatitis B virus infection; Etiologic basis of anti-HCV testing for approximating half of the cases.
KW  - HEPATITIS C
KW  - TESTING
KW  - IMMUNOGLOBULINS
KW  - SERUM
N1  - Accession Number: 10983208; Mosley, James W. 1 Aach, Richard D. 1 Hollinger, F. Blaine 1 Stevens, Cladd E. 1 Barboza, Luiz H. 2 Nemo, George J. 2 holland, Paul V. 3 Bancroft, William H. 3 Zimmerman, Hyman J. 3 Geroge Kuo 4 Q-L Choo 4 Houghton, Micahel 4; Affiliation:  1: Transfusion-Transmitted Viruses Study (TTVS) Group  2: Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health  3: TTVS-NHLBI Repository Use Commitee  4: Chiron Corporation, Emeryville; Source Info: 1/5/90, Vol. 263 Issue 1, p77; Subject Term: HEPATITIS C; Subject Term: TESTING; Subject Term: IMMUNOGLOBULINS; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Schatzkin, Arthur
AU  - Clifford, Carolyn K.
AU  - Byan, David P.
AU  - Greenwald, Peter
AU  - Freedman, Lawrence S.
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/12/
VL  - 263
IS  - 2
M3  - Letter
SP  - 238
EP  - 238
SN  - 00987484
AB  - Replies to comments on an article published in an issue of the 'Journal of the American Medical Association' about the relationship between dietary fat and breast cancer.
KW  - FOOD -- Fat content
KW  - BREAST cancer
N1  - Accession Number: 10982668; Schatzkin, Arthur 1 Clifford, Carolyn K. 1 Byan, David P. 1 Greenwald, Peter Freedman, Lawrence S.; Affiliation:  1: Department of Health and National Cancer institute, Bethesda; Source Info: 1/12/90, Vol. 263 Issue 2, p238; Subject Term: FOOD -- Fat content; Subject Term: BREAST cancer; Number of Pages: 1/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Waldman, Thomas A.
T1  - The Multichain Interleukin 2 Receptor.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/12/
VL  - 263
IS  - 2
M3  - Article
SP  - 272
EP  - 274
SN  - 00987484
AB  - Focuses on multichain interleukin 2 (IL-2) receptor as a target for immunotherapy in lymphoma, autoimmune disorders and organ allograft.  Use of anti-Tac monoclonal antibody targeted against IL-2; Ways to improve IL-2 receptor-directed therapy.
KW  - INTERLEUKIN-2
KW  - LYMPHOMAS
KW  - AUTOIMMUNE diseases
KW  - HOMOGRAFTS
N1  - Accession Number: 10982716; Waldman, Thomas A. 1; Affiliation:  1: Matabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md; Source Info: 1/12/90, Vol. 263 Issue 2, p272; Subject Term: INTERLEUKIN-2; Subject Term: LYMPHOMAS; Subject Term: AUTOIMMUNE diseases; Subject Term: HOMOGRAFTS; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Benfante, Richard
AU  - Reed, Dwayne
T1  - Is Elevated Serum Cholesterol Level a Risk Factor for Coronary Heart Disease in the Elderly?
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/19/
VL  - 263
IS  - 3
M3  - Article
SP  - 393
EP  - 396
SN  - 00987484
AB  - Examines the association between serum cholesterol level and coronary heart disease (CHD) in the elderly.  Incidence rates of CHD; Relative risks for middle-aged men; Levels of high- and low-density lipoproteins; Biological component of atherosclerosis; Other risk factors for CHD; Analysis of systolic blood pressure.
KW  - CORONARY heart disease -- Risk factors
KW  - BLOOD cholesterol
KW  - OLDER people -- Diseases
KW  - BLOOD lipoproteins
N1  - Accession Number: 10981146; Benfante, Richard 1 Reed, Dwayne 2; Affiliation:  1: Kuakini Medical Center, Honolulu Heart Program  2: National Heart, Lung, and Blood Institute, Honolulu Heart Program; Source Info: 1/19/90, Vol. 263 Issue 3, p393; Subject Term: CORONARY heart disease -- Risk factors; Subject Term: BLOOD cholesterol; Subject Term: OLDER people -- Diseases; Subject Term: BLOOD lipoproteins; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Costa Jr., Paul T.
AU  - Zonderman, Alan B.
AU  - McCrae, Robert R.
T1  - In Reply.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/01/26/
VL  - 263
IS  - 4
M3  - Letter
SP  - 514
EP  - 514
SN  - 00987484
AB  - Presents a letter to the editor in the January 26, 1989 issue of the 'Journal of the American Medical Association,' about the suggestion that depression may be a risk factor for a subgroup of cancers that are sensitive to immunodeficiency.
KW  - CANCER
KW  - MENTAL depression
KW  - IMMUNODEFICIENCY
KW  - LETTERS to the editor
N1  - Accession Number: 10981227; Costa Jr., Paul T. 1 Zonderman, Alan B. 1 McCrae, Robert R. 1; Affiliation:  1: National Institute on Aging, National Institute of Health, Baltimore, Md; Source Info: 1/26/90, Vol. 263 Issue 4, p514; Subject Term: CANCER; Subject Term: MENTAL depression; Subject Term: IMMUNODEFICIENCY; Subject Term: LETTERS to the editor; Number of Pages: 1/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1990-22982-001
AN  - 1990-22982-001
AU  - Stager, Sheila V.
T1  - Heterogeneity in stuttering: Results from auditory brainstem response testing.
JF  - Journal of Fluency Disorders
JO  - Journal of Fluency Disorders
JA  - J Fluency Disord
Y1  - 1990/02//
VL  - 15
IS  - 1
SP  - 9
EP  - 19
CY  - Netherlands
PB  - Elsevier Science
SN  - 0094-730X
N1  - Accession Number: 1990-22982-001. Partial author list: First Author & Affiliation: Stager, Sheila V.; NIH, NIDCD Intramural Research Program Speech & Voice Unit, Bethesda, MD, US. Release Date: 19900901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: American Speech-Language-Hearing Association Convention (1982, Toronto, Canada). Major Descriptor: Auditory Evoked Potentials; Brain Stem; Stuttering. Minor Descriptor: Afferent Pathways. Classification: Speech & Language Disorders (3270). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 11. Issue Publication Date: Feb, 1990. 
AB  - Compared measures of intactness of the brainstem auditory pathway from the auditory brainstem response in 10 male stutterers (aged 16–36 yrs) and 12 age-matched male nonstutterers with normal-hearing sensitivity. Measures reflecting intactness included (1) interpeak latency between Waves I and V, (2) amplitude ratio greater than 1 between Waves V and I, and (3) latency shift in Wave V between low and high stimulus presentation rates. As a group, stutterers did not differ from nonstutterers on any of these measures. Individually, half the stutterers demonstrated latencies greater than 2 standard deviations from nonstutterers' means on at least 1 measure. Results demonstrate abnormality in the brainstem auditory pathway in some stutterers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - measures of intactness of brain stem auditory pathway from auditory brain stem response
KW  - male 16–36 yr old stutterers
KW  - conference presentation
KW  - 1990
KW  - Auditory Evoked Potentials
KW  - Brain Stem
KW  - Stuttering
KW  - Afferent Pathways
KW  - 1990
DO  - 10.1016/0094-730X(90)90028-Q
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1990-22982-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-20925-001
AN  - 2009-20925-001
AU  - Glasner, Peter D.
AU  - Kaslow, Richard A.
T1  - The epidemiology of human immunodeficiency virus infection.
T3  - Special Series: Acquired Immune Deficiency Syndrome
JF  - Journal of Consulting and Clinical Psychology
JO  - Journal of Consulting and Clinical Psychology
JA  - J Consult Clin Psychol
Y1  - 1990/02//
VL  - 58
IS  - 1
SP  - 13
EP  - 21
CY  - US
PB  - American Psychological Association
SN  - 0022-006X
SN  - 1939-2117
AD  - Glasner, Peter D., Microbiology and Infectious Disease Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Westwood Building, Room 739, Bethesda, MD, US, 20892
N1  - Accession Number: 2009-20925-001. PMID: 2181000 Other Journal Title: Journal of Consulting Psychology. Partial author list: First Author & Affiliation: Glasner, Peter D.; National Institute of Allergy and Infectious Diseases, Bethesda, MD, US. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 20091221. Correction Date: 20100621. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; History; HIV. Minor Descriptor: AIDS. Classification: Immunological Disorders (3291). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Feb, 1990. Publication History: Accepted Date: Jun 21, 1989; Revised Date: Jun 21, 1989; First Submitted Date: Jun 5, 1989. Copyright Statement: American Psychological Association, Inc. 1990. 
AB  - The epidemiology and natural history of infection with the human immunodeficiency virus (HIV) is reviewed. HIV is associated with a broad spectrum of disease, including AIDS. In presenting the natural history, early and late clinical manifestations, diagnosis of infection, incubation and latency periods, and survival time are discussed. Data from the published literature on the distribution of HIV infection in the adult U.S. population and factors that affect the acquisition and spread of the virus are also reviewed. Understanding of the epidemiology of this infection in certain high-risk groups is substantial and has provided a clear focus for preventive efforts and counseling. Many questions about spread in heterosexuals and about factors that may affect the natural history of the disease await completion of ongoing and planned studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - epidemiology
KW  - human immunodeficiency virus
KW  - HIV
KW  - AIDS
KW  - history
KW  - 1990
KW  - Epidemiology
KW  - History
KW  - HIV
KW  - AIDS
KW  - 1990
DO  - 10.1037/h0092560
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-20925-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - NEWS
AU  - Williams, T. Franklin
T1  - Osteoporosis and Hip Fractures: Challenges to Investigators and Clinicians.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/02/02/
VL  - 263
IS  - 5
M3  - Editorial
SP  - 708
EP  - 709
SN  - 00987484
AB  - Editorial.  Comments on the article 'Appendicular Bone Density and Age Predict Hip Fracture in Women' published in the February 2, 1990 issue of the 'Journal of the American Medical Association.'  Relationship between measurements of bone density and occurrence of hip fractures; Importance of early post-operative, comprehensive, geriatrically-oriented rehabilitation.
KW  - HIP joint
KW  - FRACTURES
KW  - BONE densitometry
N1  - Accession Number: 10981046; Williams, T. Franklin 1; Affiliation:  1: National Institute on Aging; Source Info: 2/2/90, Vol. 263 Issue 5, p708; Subject Term: HIP joint; Subject Term: FRACTURES; Subject Term: BONE densitometry; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Liotta, Lance A.
AU  - Kohn, Elise
AU  - Liotta, L A
AU  - Kohn, E
T1  - Cancer invasion and metastases.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/02/23/
VL  - 263
IS  - 8
M3  - journal article
SP  - 1123
EP  - 1126
SN  - 00987484
AB  - Discusses developments in the biochemical and genetic mechanisms of tumor progression to the metastatic phenotype.  Major challenge to investigator who study cancer metastases; Relation between the organ distribution of metastases and the site of the primary tumor; Factor causing the tumor cells to metastasize; Mechanism for homing.
KW  - CANCER invasiveness
KW  - METASTASIS
KW  - DNA
KW  - PHYSIOLOGY
KW  - BREAST tumors
KW  - CANCER relapse
KW  - ONCOGENES
KW  - PHENOTYPE
N1  - Accession Number: 11021092; Liotta, Lance A. 1 Kohn, Elise 2 Liotta, L A 3 Kohn, E; Affiliation:  1: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Md  2: Medicine Branch, National Cancer Institute, National Institutes of Health, Md  3: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 2/23/90, Vol. 263 Issue 8, p1123; Subject Term: CANCER invasiveness; Subject Term: METASTASIS; Subject Term: DNA; Subject Term: PHYSIOLOGY; Subject Term: BREAST tumors; Subject Term: CANCER relapse; Subject Term: ONCOGENES; Subject Term: PHENOTYPE; Number of Pages: 4p; Illustrations: 2 Diagrams, 2 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107950352
T1  - Coping With Grief in Response to Caring for Persons With AIDS.
AU  - Piemme, Joan A.
AU  - Bolle, Jacques L.
Y1  - 1990/03//
N1  - Accession Number: 107950352. Language: English. Entry Date: 20130621. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 7705978. 
KW  - Acquired Immunodeficiency Syndrome -- Psychosocial Factors
KW  - Caregivers
KW  - Grief
KW  - Coping
KW  - Occupational Therapists
KW  - Role
KW  - Professional-Patient Relations
SP  - 266
EP  - 269
JO  - American Journal of Occupational Therapy
JF  - American Journal of Occupational Therapy
JA  - AM J OCCUP THER
VL  - 44
IS  - 3
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
AB  - AIDS has or will affect virtually every professional health care provider. Occupational therapists are in a key position to identify and intervene with the social and occupational changes and losses commonly experienced by this patient population. Suggestions are provided to assist occupational therapists in helping patients with AIDS maintain meaning in their lives. Strategies to help occupational therapists prevent burnout resulting from the emotional stress related to caring for patients with AIDS are suggested as well.
SN  - 0272-9490
AD  - Clinical Nursing Educator, Cancer Nursing Service, National Institutes of Health, Bethesda, Maryland
AD  - Psychiatric Liaison Clinical Nurse Specialist, Mental Health Nursing Service, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 2316616.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Flament, Martine F.
AU  - Koby, Elisabeth
AU  - Rapoport, Judith L.
AU  - Berg, Carol J.
AU  - Zahn, Theodore
AU  - Cox, Christine
AU  - Denckla, Martha
AU  - Lenane, Marge
T1  - Childhood Obsessive-Compulsive Disorder: A Prospective Follow-up Study.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1990/03//
VL  - 31
IS  - 3
M3  - Article
SP  - 363
EP  - 380
SN  - 00219630
AB  - Twenty-five of 27 patients (93 %) who had participated in a study of severe primary obsessive-compulsive disorder with onset in childhood or adolescence, were seen 2-7 yrs after initial examination (mean, 4.4 yrs). They were compared to a group of normal controls matched for age, sex and IQ, and followed up for the same period. Continued psychopathology was striking for the patients, with only seven (28%), three males and four females, receiving no psychiatric diagnosis at follow-up. Seventeen subjects (68%) still had obsessive-compulsive disorder, 12 patients (48%) had another psychiatric disorder, most commonly anxiety and/or depression; neither initial response to clomipramine or any other baseline variable predicted outcome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Child Psychology & Psychiatry & Allied Disciplines is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OBSESSIVE-compulsive disorder
KW  - ADOLESCENCE
KW  - CHILDREN
KW  - ANXIETY
KW  - NEUROSES
KW  - PSYCHIATRIC diagnosis
KW  - adolescence
KW  - clomipramine
KW  - follow-up
KW  - Obsessive-compulsive disorder
N1  - Accession Number: 11909649; Flament, Martine F. 1 Koby, Elisabeth 2 Rapoport, Judith L. 2 Berg, Carol J. 2 Zahn, Theodore 3 Cox, Christine 4 Denckla, Martha 5 Lenane, Marge 2; Affiliation:  1: Hôpital International de I'Université de Paris, Paris, France.  2: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, U.S.A..  3: Laboratory of Psychology and Psychopathology, NIMH, Bethesda, MD 20892, U.S.A..  4: Laboratory of Neuropsychology, National Institute of Neurological Disorders and Stroke, NIMH, Bethesda, MD 20892, U.S.A..  5: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A..; Source Info: Mar1990, Vol. 31 Issue 3, p363; Subject Term: OBSESSIVE-compulsive disorder; Subject Term: ADOLESCENCE; Subject Term: CHILDREN; Subject Term: ANXIETY; Subject Term: NEUROSES; Subject Term: PSYCHIATRIC diagnosis; Author-Supplied Keyword: adolescence; Author-Supplied Keyword: clomipramine; Author-Supplied Keyword: follow-up; Author-Supplied Keyword: Obsessive-compulsive disorder; Number of Pages: 18p; Document Type: Article
L3  - 10.1111/1469-7610.ep11909649
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scott, J.
AU  - Wolff, A.
AU  - Fox, P. C.
T1  - Histologic assessment of the submandibular glands in autoimmune-disease-prone mice.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1990/03//
VL  - 19
IS  - 3
M3  - Article
SP  - 131
EP  - 135
SN  - 09042512
AB  - Submandibular glands were examined from three autoimmune-disease-prone strains of mice (NZB/W, MRL/1 and MRL/n) and controls (C57BL/6J). Focal lymphocytic adenitis was more prevalent and more severe in autoimmune-diseaseprone strains than controls and in females than males. Lymphocytic foci were more frequent in older age groups, but female MRL/1 mice exhibited high levels of focal lymphocytic adenitis irrespective of age. Salivary parenchyma was generally well preserved. In the strain-age groups with the highest focal lymphocytic scores proportional acinar volumes were significantly less than in controls. However, the proportion of acinar tissue showed no consistent relation to the severity of focal lymphocytic adenitis across all strains and age groups of either sex. Sexual dimorphism in granular duct prominence was weakened in NZB/W and MRL/1 strains compared to controls. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SUBMANDIBULAR gland
KW  - AUTOIMMUNE diseases
KW  - MICE as laboratory animals
KW  - LYMPHADENITIS
KW  - autoimmune disease
KW  - focal lymphocytic adenitis
KW  - mouse
KW  - salivary glands.
N1  - Accession Number: 11615335; Scott, J. 1 Wolff, A. 2 Fox, P. C. 2; Affiliation:  1: Oral Pathology and Microbiology Unit, Department of Clinical Dental Science, University of  Liverpool, England.  2: ClinicaI  Investigations and Patient Care Branch, National Institute of Dental  Research, National  Institutes of Health,  Bethesda, Maryland, USA.; Source Info: Mar1990, Vol. 19 Issue 3, p131; Subject Term: SUBMANDIBULAR gland; Subject Term: AUTOIMMUNE diseases; Subject Term: MICE as laboratory animals; Subject Term: LYMPHADENITIS; Author-Supplied Keyword: autoimmune disease; Author-Supplied Keyword: focal lymphocytic adenitis; Author-Supplied Keyword: mouse; Author-Supplied Keyword: salivary glands.; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1600-0714.ep11615335
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ruchkin, Daniel S.
AU  - Johnson Jr., Ray
AU  - Canoune, Howard L.
AU  - Ritter, Walter
AU  - Hammer, Muriel
T1  - Multiple Sources of P3b Associated with Different Types of Information.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1990/03//
VL  - 27
IS  - 2
M3  - Article
SP  - 157
EP  - 176
SN  - 00485772
AB  - This experiment investigated how the P3a, P3b, and Slow Wave components of the event-related brain potential (ERP) respond to manipulations of the nature, timing, and extent of information delivery. There were two experiments in which the total amount of task information was distributed between pairs of successive stimuli (S[Sub1] and S[Sub2]) within each trial. The task was to predict the relation between S[Sub1] and S[Sub1]. In Experiment 1, the S[Sub1] could resolve no, partial, or all uncertainty with respect to the prediction outcome (correct or incorrect). Each S[Sub1] delivered three types of information: 1) outcome information-which resolved the subjects' uncertainty about the correctness of their prediction; 2) procedural information-which resolved uncertainty about how much outcome information would be delivered by S[Sub1]; and 3) memory information-the identity of S[Sub1], which had to be stored for subsequent comparison with S[Sub2]. In Experiment 2, the activity of these components was contrasted in two conditions in which the S[Sub1] delivered either memory information alone or both memory and procedural information. P3a and Slow Wave were sensitive only to outcome information. P3b was sensitive to all three types of information, and its scalp topography varied as a function of the type of information. The topographic variations indicate that P3b is not a unitary phenomenon but rather is a composite of activity arising from multiple intracranial sources of bioelectric activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOKED potentials (Electrophysiology)
KW  - ELECTROPHYSIOLOGY
KW  - SLOW wave sleep
KW  - SLEEP -- Stages
KW  - MEMORY
KW  - PSYCHOPHYSIOLOGY
KW  - Event-related brain potentials
KW  - Information delivery
KW  - Memory.
KW  - P3a
KW  - P3b
KW  - Slow Wave
N1  - Accession Number: 11030437; Ruchkin, Daniel S. 1 Johnson Jr., Ray 2 Canoune, Howard L. 1 Ritter, Walter 3 Hammer, Muriel 4; Affiliation:  1: Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland.  2: Cognitive Neuroscience Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.  3: Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New york, and Department of Psychology, lehman College, City University of New York.  4: Department of Epidemiological Brain Disorders, new York State Psychiatric Institute, New York City.; Source Info: Mar1990, Vol. 27 Issue 2, p157; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: ELECTROPHYSIOLOGY; Subject Term: SLOW wave sleep; Subject Term: SLEEP -- Stages; Subject Term: MEMORY; Subject Term: PSYCHOPHYSIOLOGY; Author-Supplied Keyword: Event-related brain potentials; Author-Supplied Keyword: Information delivery; Author-Supplied Keyword: Memory.; Author-Supplied Keyword: P3a; Author-Supplied Keyword: P3b; Author-Supplied Keyword: Slow Wave; Number of Pages: 20p; Document Type: Article
L3  - 10.1111/1469-8986.ep11030437
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05394-106
AN  - 2006-05394-106
AU  - Shah, Saleem A.
T1  - The critique wasn't as critical as the author represents.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1990/03//
VL  - 35
IS  - 3
SP  - 304
EP  - 305
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05394-106. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061211. Correction Date: 20160912. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Adjudication; Forensic Psychology; Legal Processes; Sociocultural Factors. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 1990. 
AB  - Saleem A. Shah replies to the comments Michael King (see record [rid]2006-05394-105[/rid]) on Shah's review (see record [rid]2006-05463-009[/rid]) of King's book Psychology In and Out of Court (see record [rid]1987-97211-000[/rid]). Shah maintains that the basic thrust of his criticism pertained to the manner in which King often makes ascriptions and broad assertions in his book. His statement that 'Logical Positivism is alive and well in legal psychology' was used to illustrate this general point. The review did not take the author to task for his failure to have visited the United States to review academic programs systematically; rather, it questioned the basis for his assertion. In such cases, the burden of providing substantiation is on the person making the assertion; it should not be necessary for reviewers and readers to have to examine 'the contents of [King's] armoury in England!' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - legal psychology
KW  - court
KW  - sociocultural processes
KW  - legal processes
KW  - 1990
KW  - Adjudication
KW  - Forensic Psychology
KW  - Legal Processes
KW  - Sociocultural Factors
KW  - 1990
DO  - 10.1037/028443
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Raub, William
T1  - From the National Institutes of Health.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/03/02/
VL  - 263
IS  - 9
M3  - Article
SP  - 1189
EP  - 1189
SN  - 00987484
AB  - Cites several medical reports from the U.S. National Institutes of Health.  'Prenatal Aspirin Use Does Not Increase Risk of Fetal Cardiac Detects'; 'New Method for Estimating Women's Breast Cancer Risk'; 'How Can You Help Patients Stop Smoking: Opportunities for Respiratory Care Practitioners.'
KW  - MEDICAL research
KW  - ASPIRIN
KW  - BREAST cancer
KW  - UNITED States
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 10983095; Raub, William 1; Affiliation:  1: National Institutes of Health; Source Info: 3/2/90, Vol. 263 Issue 9, p1189; Subject Term: MEDICAL research; Subject Term: ASPIRIN; Subject Term: BREAST cancer; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Evans, Michele R.
AU  - Henderson, David K.
AU  - Bennett, John E.
T1  - Potential for Laboratory Exposure to Biohazardous Agents Found in Blood.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/04//
VL  - 80
IS  - 4
M3  - Article
SP  - 423
EP  - 427
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The magnitude of risk for occupational exposures to biohazardous agents found m blood was assessed by 800 environmental samples taken from a total of 10 clinical and research laboratories at the National Institutes of Health (NIH). Thirty-one samples from 11 work stations m three laboratories contained hepatitis B virus surface antigen (HBsAg) Observations of workers indicated that environmental contamination arose from several sources. Among the 11 work stations with HBsAg environmental samples, eight had high work loads, seven had inappropriate behaviors, and nine had flawed laboratory techniques. This information suggests that a multifactorial approach is needed to minimize the risk of laboratory-associated infections, tam J Public Health 1990;80:423-427.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS B virus
KW  - CELL surface antigens
KW  - HAZARDOUS substances
KW  - HEALTH risk assessment
KW  - RISK management in business
KW  - BLOOD diseases
KW  - INDUSTRIAL hygiene
KW  - WORK environment
KW  - OCCUPATIONAL hazards
KW  - UNITED States
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 4683787; Evans, Michele R. 1 Henderson, David K. 2 Bennett, John E. 3; Affiliation:  1: National Institutes of Health, Environmental Safety Program  2: National Institutes of Health, Epidemiology Services  3: National Institutes of Health, Warren G. Magnuson Clinical Center, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; Source Info: Apr90, Vol. 80 Issue 4, p423; Subject Term: HEPATITIS B virus; Subject Term: CELL surface antigens; Subject Term: HAZARDOUS substances; Subject Term: HEALTH risk assessment; Subject Term: RISK management in business; Subject Term: BLOOD diseases; Subject Term: INDUSTRIAL hygiene; Subject Term: WORK environment; Subject Term: OCCUPATIONAL hazards; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mage, Rose G.
T1  - Lymphoid cells and natural immunity .
JO  - BioScience
JF  - BioScience
Y1  - 1990/04//
VL  - 40
IS  - 4
M3  - Book Review
SP  - 309
EP  - 310
SN  - 00063568
AB  - Reviews the book `Functions of the Natural Immune System,' edited by Craig W. Reynolds and Robert H. Wiltrout.
KW  - Immune system
KW  - Nonfiction
KW  - Functions of the Natural Immune System (Book)
N1  - Accession Number: 9005210459; Mage, Rose G. 1; Affiliations: 1: Molecular Immunogenetics, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892; Issue Info: Apr90, Vol. 40 Issue 4, p309; Subject Term: Immune system; Subject Term: Nonfiction; Reviews & Products: Functions of the Natural Immune System (Book); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 1149
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Fuchs, D.
AU  - Shearer, G. M.
AU  - Boswell, R. N.
AU  - Clerici, M.
AU  - Reibnegger, G.
AU  - Werner, E. R.
AU  - Zajac, R. A.
AU  - Wachter, H.
T1  - Increased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 production.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1990/04//
VL  - 80
IS  - 1
M3  - Article
SP  - 44
EP  - 48
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Recently we have observed that the CD4+ T cell response of peripheral blood mononuclear cells (PBMC) to soluble antigens is the first to be lost in the course of HIV-1 infection followed by the loss of response to HLA alloantigens. In this study we compared serum neopterin concentrations of individuals with early stages of HIV-1 infection (stages WR1 and WR2, Walter Reed staging system) with in vitro interleukin-2 (IL-2) production of PBMC in response to stimulation with soluble antigens (influenza A virus and tetanus toxoid) and alloantigens. Neopterin concentrations were significantly higher in HIV-1-seropositive individuals who showed deficient IL-2 production in response to recall antigens only or to all of the stimuli tested in vitro, compared with HIV-1-seropositive individuals who exhibited no CD4+ T cell defects. No difference in serum neopterin concentrations was observed between the group that was functionally deficient to soluble antigens only versus those who were unresponsive to both types of stimuli. It appears that the selective loss of the MHC self-restricted CD4+ T cell function is associated with an increase in serum neopterin levels. Neopterin concentrations are an estimate of the activation status of macrophages. We conclude that defective in vitro production of lymphokines by T lymphocytes is associated with activated macrophages in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - HIV infections
KW  - LYMPHOCYTES
KW  - NEOPTERIN
KW  - ANTIGENS
KW  - BIOCHEMICAL markers
KW  - cellular immunity
KW  - HIV infection
KW  - interleukin-2 production in vitro macrophage activation in vivo
KW  - neopterin
N1  - Accession Number: 15950707; Fuchs, D. 1 Shearer, G. M. 2 Boswell, R. N. 3 Clerici, M. 2 Reibnegger, G. 1 Werner, E. R. 1 Zajac, R. A. 3 Wachter, H. 1; Affiliation:  1: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, and Ludwig Boltzmann Institute of AIDS Research Innsbruck, Austria.  2: Experimental Immunology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD.  3: HIV Unit/SGHMMM, Wilford Hall, Lackland Air Force Base, TX, USA.; Source Info: Apr1990, Vol. 80 Issue 1, p44; Subject Term: INTERLEUKIN-2; Subject Term: HIV infections; Subject Term: LYMPHOCYTES; Subject Term: NEOPTERIN; Subject Term: ANTIGENS; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: cellular immunity; Author-Supplied Keyword: HIV infection; Author-Supplied Keyword: interleukin-2 production in vitro macrophage activation in vivo; Author-Supplied Keyword: neopterin; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1365-2249.ep15950707
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sica, A.
AU  - Matsushima, K.
AU  - van Damme, J.
AU  - Wang, J. M.
AU  - Polentarutti, N.
AU  - Dejana, E.
AU  - Colotta, F.
AU  - Mantovani, A.
T1  - IL-1 transcriptionally activates the neutrophil chemotactic factor/IL-8 gene in endothelial cells.
JO  - Immunology
JF  - Immunology
Y1  - 1990/04//
VL  - 69
IS  - 4
M3  - Article
SP  - 548
EP  - 553
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Leucocytes and vascular cells interact closely in inflammation and immunity and cytokines are important mediators of this interaction. The present study was designed to define the capacity of human endothelial cells (HEC) to produce a monocyte-derived neutrophil chemotactic factor (provisionally termed IL-8). IL-8 is a polypeptide chemotactic for neutrophils originally identified in the culture supernatant of lipopolysaccharide (LPS)-stimulated monocytes. IL-1 induced high levels of production of neutrophil chemotactic activity in culture supernatants of HEC. Optimal stimulation of activity was observed when HEC were cultured with 10–100 ng/ml IL-1β for 16 hr. Anti-IL-8 antibody blocked the chemotactic activity for neutrophils of IL-1-activated HEC supernatants. IL-1-treated HEC expressed high levels of IL-8 mRNA transcripts, as assessed by Northern blot analysis. Tumour necrosis factor (TNF) and LPS, unlike the inflammatory monokine IL-6, also induced IL-8 expression. Nuclear run-off experiments revealed that IL-1 activated transcription of the IL-8 gene. The production of IL-8 may represent a mechanism whereby endothelial cells, exposed to inflammatory signals, participate in the regulation of neutrophil extravasation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUCOCYTES
KW  - KILLER cells
KW  - BLOOD cells
KW  - CYTOKINES
KW  - IMMUNE response -- Regulation
KW  - CELLULAR immunity
KW  - MESSENGER RNA
N1  - Accession Number: 13350030; Sica, A. 1 Matsushima, K. 2 van Damme, J. 3 Wang, J. M. 1 Polentarutti, N. 1 Dejana, E. 1 Colotta, F. 1 Mantovani, A. 1; Affiliation:  1: Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy  2: Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland, USA  3: Rega Institute for Medical Research, University of Leuven, Leuven, Belgium; Source Info: Apr90, Vol. 69 Issue 4, p548; Subject Term: LEUCOCYTES; Subject Term: KILLER cells; Subject Term: BLOOD cells; Subject Term: CYTOKINES; Subject Term: IMMUNE response -- Regulation; Subject Term: CELLULAR immunity; Subject Term: MESSENGER RNA; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Graves, P.M.
AU  - Burkot, T.R.
AU  - Saul, A.J.
AU  - Hayes, R.J.
AU  - Carter, R.
T1  - ESTIMATION OF ANOPHELINE SURVIVAL RATE VECTORIAL CAPACITY AND MOSQUITO INFECTION PROBABILITY FROM MALARIA VECTORI INFECTION RATES IN VILLAGES NEAR MADANG, PAPUA NEW GUINEA.
JO  - Journal of Applied Ecology
JF  - Journal of Applied Ecology
Y1  - 1990/04//
VL  - 27
IS  - 1
M3  - Article
SP  - 134
EP  - 147
PB  - Wiley-Blackwell
SN  - 00218901
AB  - Determines the indices of the intensity of malaria transmission in three villages near Madang, Papua New Guinea over an 18-month period.  Mosquito survival per feeding cycle; Survival per extrinsic incubation period; Vectorial capacity and mosquito infection probability.
KW  - MALARIA
KW  - MOSQUITOES as carriers of disease
KW  - ANIMALS as carriers of disease
KW  - INFECTION
KW  - EPIDEMIOLOGY
KW  - TRANSMISSION
KW  - PAPUA New Guinea
N1  - Accession Number: 12263977; Graves, P.M. 1 Burkot, T.R. 1 Saul, A.J. 2 Hayes, R.J. 3 Carter, R. 4; Affiliation:  1: Papua new Guinea Institute of Medical Research, Papua New Guinea  2: Queensland Institute of Medical Research, Queensland  3: Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine, U.K.  4: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda; Source Info: Apr90, Vol. 27 Issue 1, p134; Subject Term: MALARIA; Subject Term: MOSQUITOES as carriers of disease; Subject Term: ANIMALS as carriers of disease; Subject Term: INFECTION; Subject Term: EPIDEMIOLOGY; Subject Term: TRANSMISSION; Subject Term: PAPUA New Guinea; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Swerlick, Robert A.
AU  - Yancey, Kim B.
AU  - Lawley, Thomas J.
T1  - Inflammatory Properties of Human C5a and C5a des Arg in Mast Cell-Depleted Human Skin Reply.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/04//
VL  - 94
IS  - 4
M3  - Letter
SP  - 499
EP  - 499
SN  - 0022202X
AB  - Presents a response by the author to a letter to the editor about the article "Inflammatory Properties of Human C5a and CSa des Arg in Mast Cell-Depleted Human Skin," in the previous issue of the "Journal of Investigative Dermatology."
KW  - LETTERS to the editor
KW  - SKIN diseases
N1  - Accession Number: 12874704; Swerlick, Robert A. 1 Yancey, Kim B. 1 Lawley, Thomas J. 1; Affiliation:  1: National Cancer Institute Bethesda, Maryland.; Source Info: Apr90, Vol. 94 Issue 4, p499; Subject Term: LETTERS to the editor; Subject Term: SKIN diseases; Number of Pages: 1/4p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12874704
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2014-04058-001
AN  - 2014-04058-001
AU  - Parrish, Jacqueline
T1  - Supported housing: A critical component of effective community support.
T3  - Supported Housing: New Approaches to Residential Services
JF  - Psychosocial Rehabilitation Journal
JO  - Psychosocial Rehabilitation Journal
Y1  - 1990/04//
VL  - 13
IS  - 4
SP  - 9
EP  - 10
CY  - US
PB  - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN  - 0147-5622
N1  - Accession Number: 2014-04058-001. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Parrish, Jacqueline; Community Support Program, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Homeless Mentally Ill; Housing; Mental Health; Nursing Homes. Minor Descriptor: Mental Disorders. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 2. Issue Publication Date: Apr, 1990. 
AB  - This article highlights, from the National Institute of Mental Health (NIMH) Community Support Program (CSP) experience, that individuals with severe mental disorders cannot be treated or rehabilitated when they do not have a stable, decent place to live. Furthermore, lack of housing is largely responsible for unnecessary and prolonged hospitalization, inappropriate placement in nursing homes, enormous burdens on families, and homelessness. The reasons for lack of housing are primarily lack of resources and lack of knowledge. Based on the results of early planning meetings in 1983 and 1984, CSP undertook a number of initiatives to address the resource and knowledge gaps. In order to build the knowledge base, five 3-year CSP Supported Housing Demonstration Projects were funded in 1988. A national evaluation is currently being conducted on these projects. In its national leadership role, CSP supported several working meetings of state commissioners that resulted in 1987 in the development of a mission statement on housing by the National Association of State Mental Health Program Directors and the issuance of a housing policy statement by NIMH. However, in spite of these significant developments in the housing area, there are still serious challenges ahead. The need to improve the lives of the many individuals in substandard, custodial, abusive board-and-care homes must not be forgotten. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Community Support Program
KW  - housing
KW  - mental disorders
KW  - mental health
KW  - nursing homes
KW  - homelessness
KW  - 1990
KW  - Community Services
KW  - Homeless Mentally Ill
KW  - Housing
KW  - Mental Health
KW  - Nursing Homes
KW  - Mental Disorders
KW  - 1990
DO  - 10.1037/h0099480
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2007-10297-001
AN  - 2007-10297-001
AU  - Judd, Lewis L.
T1  - Research and action.
JF  - American Journal of Orthopsychiatry
JO  - American Journal of Orthopsychiatry
JA  - Am J Orthopsychiatry
Y1  - 1990/04//
VL  - 60
IS  - 2
SP  - 311
EP  - 312
CY  - US
PB  - American Orthopsychiatric Association, Inc.
SN  - 0002-9432
SN  - 1939-0025
N1  - Accession Number: 2007-10297-001. PMID: 2343896 Partial author list: First Author & Affiliation: Judd, Lewis L.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20070716. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Major Descriptor: Experimental Psychology; Experimentation; Government Policy Making; Homeless; Mental Health. Minor Descriptor: Hypothesis Testing. Classification: Social Processes & Social Issues (2900). Page Count: 2. Issue Publication Date: Apr, 1990. Copyright Statement: American Orthopsychiatric Association, Inc. 1990. 
AB  - The present letter is in response to Milton F. Shore's editorial entitled 'The Perversion of Research and the Paralysis of Action' (Journal, October, 1989). In that editorial, Dr. Shore decried the National Institute of Mental Health's recent attempts to encourage hypothesis testing in new research on homelessness and suggested that research of this sort is a mere substitute for effective governmental action. The present author contends that this statement about the NIMH is factually incorrect, and this letter attempts to replace the misinformation in Dr. Shore's editorial with fact. The NIMH is an action-oriented agency that believes that it is the agency's responsibility to see to it that actions are based on the best available data--data which can only come from a relevant, broad, and rigorous research effort. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - homelessness
KW  - research
KW  - governmental action
KW  - role of National Institute of Mental Health
KW  - 1990
KW  - Experimental Psychology
KW  - Experimentation
KW  - Government Policy Making
KW  - Homeless
KW  - Mental Health
KW  - Hypothesis Testing
KW  - 1990
DO  - 10.1037/h0085001
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Klippel, John H.
AU  - Rosen, Saul
AU  - Klippel, J H
T1  - Systemic lupus erythematosus. Treatment-related complications superimposed on chronic disease.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/04/04/
VL  - 263
IS  - 13
M3  - journal article
SP  - 1812
EP  - 1815
SN  - 00987484
AB  - Presents a case report of a woman with systemic lupus erythematosus.  Major chronic manifestation of the disease; Morbidity of the disease; Drug treatment.
KW  - SYSTEMIC lupus erythematosus
KW  - LUPUS erythematosus
KW  - SKIN diseases
KW  - COLLAGEN diseases
KW  - WOMEN -- Diseases
N1  - Accession Number: 10340665; Klippel, John H. Rosen, Saul Klippel, J H 1; Affiliation:  1: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Md; Source Info: 4/4/90, Vol. 263 Issue 13, p1812; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: LUPUS erythematosus; Subject Term: SKIN diseases; Subject Term: COLLAGEN diseases; Subject Term: WOMEN -- Diseases; Number of Pages: 4p; Illustrations: 2 Black and White Photographs, 1 Chart, 1 Graph; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Selby, Joseph V.
AU  - FitzSimmons, Stacey C.
AU  - Newman, Jeffrey M.
AU  - Katz, Patricia P.
AU  - Sepe, Stephen
AU  - Showstack, Jonathan
T1  - The Natural History and Epidemiology of Diabetic Nephropathy.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/04/11/
VL  - 263
IS  - 14
M3  - Article
SP  - 1954
EP  - 1960
SN  - 00987484
AB  - Focuses on the natural history and epidemiology of diabetic nephropathy.  Clinical stages of diabetic nephropathy; Risk factors for development and progression of diabetic nephropathy; Age and duration of disease; Prevention strategy for individual patients; public health prevention strategy.
KW  - DIABETIC nephropathies
KW  - KIDNEY diseases
N1  - Accession Number: 11020734; Selby, Joseph V. 1,2 FitzSimmons, Stacey C. 3 Newman, Jeffrey M. 4 Katz, Patricia P. 2 Sepe, Stephen 4 Showstack, Jonathan 2; Affiliation:  1: Division of Research, Kaiser Permanente Medical Care Program  2: Institute for Health Policy Studies, School of Medicine, University of California  3: Epidemiology Program, National Institute of Diabetes and Digestive and Kidney Diseases  4: Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control; Source Info: 4/11/90, Vol. 263 Issue 14, p1954; Subject Term: DIABETIC nephropathies; Subject Term: KIDNEY diseases; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Henningfield, Jack E.
AU  - London, Edyth D.
AU  - Benowitz, Neal L.
AU  - Henningfield, J E
AU  - London, E D
AU  - Benowitz, N L
T1  - Arterial-venous differences in plasma concentrations of nicotine after cigarette smoking.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/04/18/
VL  - 263
IS  - 15
M3  - letter
SP  - 2049
EP  - 2050
SN  - 00987484
AB  - Presents a letter to the editor of the 'Journal of the American Medical Association,' describing a study of the effects of cocaine on regional cerebral metabolism, which required insertion of venous and arterial catheters in volunteers and provided an opportunity to measure concentrations of nicotine in arterial and venous blood after smoking a cigarette.
KW  - NICOTINE
KW  - SMOKING
KW  - CIGARETTE smoke
KW  - CIGARETTE smokers
KW  - RESEARCH
KW  - COCAINE
KW  - ARTERIES
KW  - BLOOD
KW  - VEINS
N1  - Accession Number: 11020840; Henningfield, Jack E. 1 London, Edyth D. 1 Benowitz, Neal L. 2 Henningfield, J E London, E D Benowitz, N L; Affiliation:  1: National Institute on Drug Abuse, Baltimore, Md  2: San Francisco (Calif) General Hospital; Source Info: 4/18/90, Vol. 263 Issue 15, p2049; Subject Term: NICOTINE; Subject Term: SMOKING; Subject Term: CIGARETTE smoke; Subject Term: CIGARETTE smokers; Subject Term: RESEARCH; Subject Term: COCAINE; Subject Term: ARTERIES; Subject Term: BLOOD; Subject Term: VEINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Davis, Ronald M.
AU  - Boyd, Gayle M.
AU  - Schoenborn, Charlotte A.
T1  - 'Common Courtesy' and the Elimination of Passive Smoking.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/04/25/
VL  - 263
IS  - 16
M3  - Article
SP  - 2208
EP  - 2210
SN  - 00987484
AB  - Examines the use of common courtesy in passive smoking situations in the U.S.  1987 National Health Interview survey; Percentage of smokers smoking in public places without asking other people; Nonsmokers' actions in response to secondhand smoke; Elimination of exposure to environmental tobacco smoke.
KW  - PASSIVE smoking
KW  - CIGARETTE smokers
KW  - COURTESY
KW  - UNITED States
N1  - Accession Number: 11020819; Davis, Ronald M. 1 Boyd, Gayle M. 2 Schoenborn, Charlotte A. 3; Affiliation:  1: Office of Smoking and Health, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control  2: Smoking, Tobacco, and Cancer Branch, Division of Cancer Prevention and Control, National Cancer Institute  3: Division of Health Interview Statistics, National Center for Health Statistics, Centers for Disease Control; Source Info: 4/25/90, Vol. 263 Issue 16, p2208; Subject Term: PASSIVE smoking; Subject Term: CIGARETTE smokers; Subject Term: COURTESY; Subject Term: UNITED States; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hiraoka, B. Yukihiro
AU  - Sharief, Farida S.
AU  - Yang, Yau-Wen
AU  - Li, Wen-Hsiung
AU  - Li, Steven S.-L.
T1  - The cDNA and protein sequences of mouse lactate dehydrogenase B.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/04/30/
VL  - 189
IS  - 2
M3  - Article
SP  - 215
EP  - 220
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Mouse lactate dehydrogenase-B cDNAs were isolated from cDNA libraries of macrophage (ICR strain) and thymus (F1 hybrid of C57BL/6 and CBA strains), and their nucleotide sequences determined. The lactate dehydrogenase-B cDNA insert of thymus clone m B188 consists of the protein-coding sequence (1002 nucleotides), the 5′ (46 nucleotides) and 3′ (190 nucleotides) non-coding regions, and poly(A) tail (19 nucleotides), while macrophage clone mB168 contains a partial lactate dehydrogenase cDNA insert from codon no. 55 to the poly(A) tail. Seven silent nucleotide substitutions at codon no. 142, 143, 186, 187, 241, 285 and 292, as well as a single nucleotide change in the 3′ non-coding region, were found between these different strains of mice. The predicted sequence of 333 amino acids, excluding initiation methionine, was confirmed by sequencing and/or compositional analyses of a total of 103 (31%) amino acids from tryptic peptides of mouse lactate dehydrogenase-B protein. The nucleotide sequence of the mouse coding region for lactate dehydrogenase B shows 86% identity with that of the human isoenzyme, and only eight of the 139 nucleotide differences resulted in amino acid substitutions at residues 10, 13, 14, 17. 52, 132, 236 and 317. The rates of nucleotide substitutions at synonymous and nonsynonymous sites in the mammalian lactate dehydrogenase genes are calculated. The rates of synonymous substitutions for lactate dehydrogenase genes A (muscle) and B (heart) are considerably higher than the average rate computed from human and rodent genes. The rates of nonsynonymous substitutions for lactate dehydrogenase genes A (muscle) and B (heart), particularly the latter, are highly conservative. The rates of synonymous and nonsynonymous substitutions for the lactate dehydrogenase-C gene are about the same as the average rates for mammalian genes. A phylogenetic tree of vertebrate lactate dehydrogenase protein sequences is constructed. In agreement with the previous results, this analysis further indicates that lactate dehydrogenase-C gene branched off earlier than did lactate dehydrogenase-A and lactate dehydrogenase-B genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMINO acid sequence
KW  - NUCLEOTIDE sequence
KW  - DEHYDROGENASES
KW  - ENZYMES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13759855; Hiraoka, B. Yukihiro 1 Sharief, Farida S. 1 Yang, Yau-Wen 2 Li, Wen-Hsiung 3 Li, Steven S.-L. 1; Affiliation:  1: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institute of Health, North Carolina, USA  2: Department of Cell Biology, Baylor College of Medicine, Houston, USA  3: Center for Demographic and Population Genetics, University of Texas Health Sciences Center, Houston, USA; Source Info: 4/30/90, Vol. 189 Issue 2, p215; Subject Term: AMINO acid sequence; Subject Term: NUCLEOTIDE sequence; Subject Term: DEHYDROGENASES; Subject Term: ENZYMES; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Biosca, Josep A.
AU  - Eisenberg, Evan
AU  - Reedy, Mary C.
AU  - Reedy, Michael K.
T1  - Binding of ADP and adenosine 5′-[β,γ-imido]triphosphate to insect flight muscle fibrils.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/04/30/
VL  - 189
IS  - 2
M3  - Article
SP  - 395
EP  - 399
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have studied the binding of ADP and adenosine 5′-[β,γ-imido]triphosphate (AdoPP[NH]P) to insect flight muscle fibrils. We find that 25% of the myosin heads, presumably those which do not interact with actin, bind AdoPP[NH]P with a binding constant greater than 3 × 106 M-1, similar to the binding constant of the same compound to the rabbit myosin heads which do not overlap with actin. The remaining heads in insect myofibrils bind AdoPP[NH]P with an association constant of 8 × 103 M-1 which is eight times stronger than the affinity of this compound for rabbit myosin heads in overlap with actin. Therefore, in contrast to the situation with rabbit myofibrils where AdoPP[NH]P binds much more weakly than ADP, with insect myofibrils these two adenosine phosphates bind with almost equal affinity. This is consistent with the numerous structural studies on insect flight muscle which were interpreted on the basis that most of the actomyosin sites were saturated with nucleotide at an AdoPP[NH]P concentration of 1 mM. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADENOSINE diphosphate
KW  - ADENOSINE triphosphatase
KW  - MYOSIN
KW  - ENZYMES
KW  - ACTIN
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
N1  - Accession Number: 13771944; Biosca, Josep A. 1,2 Eisenberg, Evan 1 Reedy, Mary C. 3 Reedy, Michael K. 3; Affiliation:  1: Laboratory of Cell Biology, National Institutes of Health. National Heart, Lung, and Blood Institute, Bethesda, USA  2: Departament de Bioquímica, Facultat de Ciéncies, Universitat Autónoma de Barcelona, Spain  3: Department of Anatomy, Duke University Medical Center, Durham, USA; Source Info: 4/30/90, Vol. 189 Issue 2, p395; Subject Term: ADENOSINE diphosphate; Subject Term: ADENOSINE triphosphatase; Subject Term: MYOSIN; Subject Term: ENZYMES; Subject Term: ACTIN; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zaharevitz, Daniel W.
AU  - Anderson, Lawrence W.
AU  - Strong, John M.
AU  - Hyman, Roosevelt
AU  - Cysyk, Richard L.
T1  - <em>De novo</em> synthesis of uracil nucleotides in mouse liver and intestine studied using [15N]alanine.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/04/30/
VL  - 189
IS  - 2
M3  - Article
SP  - 437
EP  - 440
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The amount of newly synthesized uracil nucleotides in mouse liver and intestine was determined by analysis of 15N incorporation into the uracil nucleotide pool of these tissues after intraperitoneal infusion of 15N-labelled amino acids. The appearance of newly synthesized uracil nucleotides was linear with time, and essentially independent of the rate of infusion of L-[15N]alanine. Varying the amino acid used in the infusion could affect the enrichment in the uracil ring nitrogens, but had no significant effect on the calculated amount of de novo synthesis. These results demonstrate the utility of this method in measuring de novo uracil nucleotide synthesis in mouse liver and intestine in vivo. The method should be a valuable tool in the effort to understand the regulation and pharmacological manipulation of de novo uracil nucleotide synthesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - URACIL
KW  - NUCLEOTIDES
KW  - AMINO acids
KW  - ALANINE
KW  - ENZYMES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13772059; Zaharevitz, Daniel W. 1 Anderson, Lawrence W. 1 Strong, John M. 1 Hyman, Roosevelt 1 Cysyk, Richard L. 1; Affiliation:  1: Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, USA; Source Info: 4/30/90, Vol. 189 Issue 2, p437; Subject Term: URACIL; Subject Term: NUCLEOTIDES; Subject Term: AMINO acids; Subject Term: ALANINE; Subject Term: ENZYMES; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rouis, Mustapha
AU  - Nigon, Fabienne
AU  - Eggerman, Thomas L.
AU  - Brewer  Jr., H. Bryan
AU  - Chapman, M. John
T1  - Apolipoprotein E expression by human-monocyte-derived macrophages.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/04/30/
VL  - 189
IS  - 2
M3  - Article
SP  - 447
EP  - 453
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The effects of opsonised zymosan and of acetylated low-density lipoprotein (AcLDL) on the synthesis and secretion of apolipoprotein E (apoE), and of apoE mRNA abundance, have been studied in human-monocyte- derived macrophages (MDM). Stimulation by opsonised zymosan led to a concentration-dependent increase in apoE secretion: non-opsonised zymosan was without effect. Incubation with AcLDL led to a concentration- dependent elevation in apoE synthesis which paralleled the increase in cellular cholesterol content. The opsonised- zymosan-induced stimulation of apoE production was additive to that resulting from cholesterol loading with AcLDL. Opsonised zymosan alone did not affect the cholesterol content of MDM. Cholesterol-loaded MDM remained responsive to opsonised zymosan stimulation, displaying a 3.5-fold elevation in apoE secretion as compared to their non-stimulated counterparts. Cell-associated apoE remained at trace levels under all conditions of cell treatment. Studies involving [35S]methionine incorporation showed de novo synthesis of apoE to be enhanced in both cholesterol-loaded and opsonised-zymosan-stimulated macrophages. Estimation of apoE mRNA in opsonised-zymosan-stimulated and control MDM by dot-blot analysis revealed similar message abundance; by contrast, elevation in cellular cholesterol content following incubation with modified LDL led to a significant increase in apoE mRNA levels. We conclude that the opsonised-zymosan-induced stimulation of apoE synthesis and secretion in human MDM may occur by a mechanism(s) independent of cellular cholesterol content. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APOLIPOPROTEIN E
KW  - LIPOPROTEINS
KW  - ZYMOSAN
KW  - MACROPHAGES
KW  - MONOCYTES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13772086; Rouis, Mustapha 1 Nigon, Fabienne 1 Eggerman, Thomas L. 2 Brewer  Jr., H. Bryan 2 Chapman, M. John 1; Affiliation:  1: Unité de Recherches sur les Lipoprotéines et l'Athérogénése, Institut National de la Santé et de la Recherche Médicale, Unité 321, Pavilion Benjamin Delessert, Hôpital de la Pitié Paris, France  2: Molecular Disease Branch. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, USA; Source Info: 4/30/90, Vol. 189 Issue 2, p447; Subject Term: APOLIPOPROTEIN E; Subject Term: LIPOPROTEINS; Subject Term: ZYMOSAN; Subject Term: MACROPHAGES; Subject Term: MONOCYTES; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shlechter, Theodore M.
AU  - Herrmann, Douglas J.
AU  - Toglia, Michael P.
T1  - An Investigation of People's Metamemories for Naturally Occurring Events.
JO  - Applied Cognitive Psychology
JF  - Applied Cognitive Psychology
Y1  - 1990/05//May/Jun90
VL  - 4
IS  - 3
M3  - Article
SP  - 213
EP  - 217
PB  - John Wiley & Sons, Inc.
SN  - 08884080
AB  - Three studies investigated the role of event salience in the validity of metamemory reports for naturally occurring events. Two studies investigated metamemory for daily forgetting behaviours as recorded on memory diaries for either 10 days (Study 1) or a month (Study 2). A third study examined metamemory for remembering recent events (consisting of the first day of class, the recent weekend, and the first experimental session). The results indicated that metamemory validity was higher for the more salient memory events, e.g. rote memory failures and memory of the first day of class. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Applied Cognitive Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - METACOGNITION
KW  - MEMORY
KW  - DIARY (Literary form)
KW  - BEHAVIOR
N1  - Accession Number: 12010864; Shlechter, Theodore M. 1 Herrmann, Douglas J. 2 Toglia, Michael P. 3; Affiliation:  1: Army Research Institute, Fort Knox Field Unit, Fort Kox, USA  2: Laboratory of Socio-Environment Studies, National Institute of Mental Health, Bethesda, USA  3: Department of Psychology, State University of New York, College of Cortland, USA; Source Info: May/Jun90, Vol. 4 Issue 3, p213; Subject Term: METACOGNITION; Subject Term: MEMORY; Subject Term: DIARY (Literary form); Subject Term: BEHAVIOR; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05396-106
AN  - 2006-05396-106
AU  - Friedman, Sarah L.
AU  - Klivington, Kenneth A.
AU  - Peterson, Rita W.
T1  - Proof is in the pudding, not the broth.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1990/05//
VL  - 35
IS  - 5
SP  - 508
EP  - 509
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05396-106. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Friedman, Sarah L.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Brain; Cognition; Frontal Lobe; Parietal Lobe. Minor Descriptor: Reticular Formation; Thalamus. Classification: Neuropsychology & Neurology (2520). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: May, 1990. 
AB  - Sarah L. Friedman, Kenneth A. Klivington and Rita W. Peterson comment on Diane McGuinness's review (see record [rid]2006-05465-009[/rid]) of their book The Brain, Cognition, and Education (1986). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - frontal lobe
KW  - visual environment
KW  - parietal lobes
KW  - cognition
KW  - education
KW  - hippocampus
KW  - 1990
KW  - Brain
KW  - Cognition
KW  - Frontal Lobe
KW  - Parietal Lobe
KW  - Reticular Formation
KW  - Thalamus
KW  - 1990
DO  - 10.1037/028669
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Kiess, Wieland
AU  - Thomas, Cheryl L.
AU  - Sklar, Mark M.
AU  - Nissley, S. Peter
T1  - β-Galactosidase decreases the binding affinity of the insulin-like-growth-factor-II/mannose-6-phosphate receptor for insulin-like-growth-factor II.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/05/31/
VL  - 190
IS  - 1
M3  - Article
SP  - 71
EP  - 77
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The insulin-like growth-factor-II/mannose-6-phosphate (IGF-II/Man6P) receptor binds two classes of ligands. insulin-like growth factors and lysosomal enzymes. We have examined the ability of the lysosomal enzyme, βgalactosidase, to modulate the binding of 125I-IGF-II to the receptor. β-Galactosidase purified from bovine testis was fractionated on a DEAE-Sephacel ion-exchange column. Column fractions were assayed for enzymatic activity and for ability to inhibit the binding of 125I-IGF-II to the IGF-II/Man6P receptor. Enzyme fractions eluting at higher NaCl concentrations which had previously been shown to exhibit greater uptake by cells in culture. exhibited greater potency in inhibiting the binding of 125I-IGF-II to the receptor. A pool of these fractions from the DEAE-Sephacel column inhibited 125I-IGF-II binding to pure receptor by 80% with the concentration required for half-maximal inhibition being 25 nM. The inhibition of binding by β-galactosidase was completely blocked by simultaneous incubation with Man6P. Inhibition of the enzymatic activity of β-galactosidase with Dgalactonic acid γ-lactone did not affect the ability of β-galactosidase to inhibit the binding of 125I-IGF-II to the receptor. Scatchard analysis of IGF-II binding to pure receptor in the presence and absence of β-galactosidase showed that β-galactosidase decreased the binding affinity for IGF-II (Kd 0.26 nM versus 1.0 nM in the presence of 57 nM β-galactosidase). We confirmed the observations of others that Man6P alone actually increases the binding of 125I-IGF-II to the IGF-II/Man6P receptor, but we found that this phenomenon was dependent upon the method of preparation of the IGF-II/Man6P receptor. Microsomal membrane preparations, solubilized membranes, and receptors purified on an IGF-II-Sepharose column all exhibited stimulation of 125I-IGF-II binding by Man6P, whereas receptors purified on lysosomal enzyme affinity columns showed little or no stimulation of 125I-IGF-II binding by Man6P. We conclude that β-galactosidase decreases the binding affinity of the IGF-II/Man-6-P receptor for IGF-II by binding with high affinity to the Man6P-recognition site. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOMATOMEDIN
KW  - MANNOSE
KW  - PHOSPHATES
KW  - CELL receptors
KW  - LIGANDS (Biochemistry)
KW  - BINDING sites (Biochemistry)
N1  - Accession Number: 13750474; Kiess, Wieland 1 Thomas, Cheryl L. 1 Sklar, Mark M. 1 Nissley, S. Peter 1; Affiliation:  1: Endocrinology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA; Source Info: 5/31/90, Vol. 190 Issue 1, p71; Subject Term: SOMATOMEDIN; Subject Term: MANNOSE; Subject Term: PHOSPHATES; Subject Term: CELL receptors; Subject Term: LIGANDS (Biochemistry); Subject Term: BINDING sites (Biochemistry); Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bjartell, Andres
AU  - Ekman, Rolf
AU  - Y. Peng Loh
T1  - Biosynthesis and processing of delta sleep-inducing peptide-like precursors in primary cultures of mouse anterior pituitary cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/05/31/
VL  - 190
IS  - 1
M3  - Article
SP  - 131
EP  - 137
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The biosynthesis and processing of material resembling delta sleep-inducing peptide (DSIP) have been studied in mouse anterior pituitary primary cell cultures. Cells were pulse/chase incubated with ³H-labelled amino acids (Gly, Arg or Ala) and cell extracts were immunoprecipitated with DSIP antiserum. Labelled DSIP-related proteins were resolved by SDS/PAGE. Multiple forms of DSIP-immunoprecipitable material were observed, including three precursors of molecular mass 50-60 kDa which were processed to two major groups of intermediates of 35-45 kDa and 9-16.5 kDa. These intermediates appear to be processed to a DSIP-related peptide (molecular mass < 3 kDa), which co-ran on reversed-phase HPLC with an endogenous form of DSIP in mouse anterior pituitary, but not with rabbit DSIP. This < 3-kDa peptide incorporated [³H]Gly, but not [³H]Arg or [³H]Ala. In addition, it incorporated [³H]glucosamine, indicating that it was a glycopeptide. Secretion studies showed release of the < 3-kDa DSIP-like glycopeptide and the 9-16.5-kDa group of intermediates into the medium. The present study demonstrates the biosynthesis of a small DSIP-like glycopeptide in mouse anterior pituitary cells, which is not identical with, but has similarities to, rabbit DSIP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PITUITARY gland
KW  - CELL culture
KW  - BIOSYNTHESIS
KW  - PEPTIDES
KW  - SLEEP
KW  - MICE
N1  - Accession Number: 13754404; Bjartell, Andres 1,2 Ekman, Rolf 2 Y. Peng Loh 1; Affiliation:  1: Section on Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, USA  2: Department of Psychiatry and Neurochemistry, Lund University, Sweden; Source Info: 5/31/90, Vol. 190 Issue 1, p131; Subject Term: PITUITARY gland; Subject Term: CELL culture; Subject Term: BIOSYNTHESIS; Subject Term: PEPTIDES; Subject Term: SLEEP; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Steenland, N. Kyle
AU  - Silverman, Debra T.
AU  - Hornung, Richard W.
T1  - Case-Control Study of Lung Cancer and Truck Driving in the Teamsters Union.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/06//
VL  - 80
IS  - 6
M3  - Article
SP  - 670
EP  - 674
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: We conducted a case-control study of lung cancer deaths in the Teamsters Union to compare the risk of different occupations within the teamsters, after controlling for smoking and other confounders. Occupations with no presumed exposure to diesel fumes were used as the nonexposed group. The study population consisted of 996 cases and 1,085 controls who had died in 1982-83 after applying for pensions. Next of kin provided information on smoking, work history, and other potential confounders. Work history data were also obtained from the Teamsters Union. While no single job category had a significant excess risk compared to the non-exposed group, certain sub-groups were elevated. The odds ratio for those with long-term employment as long-haul truckers after 1959 (an approximate date for the introduction of diesel engines) was 1.55 (95% CI: 0.97, 2.47). Long-term drivers of primarily diesel trucks had an odds ratio of 1.89 (95% CI: 1.04, 3.42). Overall, our results suggest that diesel truck drivers have an excess risk of lung cancer compared to other teamsters in jobs outside the trucking industry. However, our findings were not uniformly consistent and our data have many limitations, the most important of which is the lack of data on exposure to diesel fumes. (Am J Public Health 1990; 80:670-674.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LUNGS -- Cancer
KW  - TRANSPORT workers
KW  - SMOKING
KW  - DIESEL motor exhaust gas
KW  - PENSIONS
KW  - OCCUPATIONAL diseases
KW  - PUBLIC health
KW  - INTERNATIONAL Brotherhood of Teamsters
N1  - Accession Number: 4684898; Steenland, N. Kyle 1 Silverman, Debra T. 2 Hornung, Richard W. 1; Affiliation:  1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories. 4676 Columbia Parkway. Cincinnati, OH  2: National Cancer Institute; Source Info: Jun90, Vol. 80 Issue 6, p670; Subject Term: LUNGS -- Cancer; Subject Term: TRANSPORT workers; Subject Term: SMOKING; Subject Term: DIESEL motor exhaust gas; Subject Term: PENSIONS; Subject Term: OCCUPATIONAL diseases; Subject Term: PUBLIC health; Company/Entity: INTERNATIONAL Brotherhood of Teamsters; NAICS/Industry Codes: 526111 Trusteed pension funds; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Newman, Beth
AU  - Selby, Joseph V.
AU  - Qesenberry Jr., Charles P.
AU  - King, Mary-Claire
AU  - Friedman, Gary D.
AU  - Fabsitz, Richard R.
T1  - Nongenetic Influences of Obesity on Other Cardiovascular Disease Risk Factors: An Analysis of Identical Twins.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/06//
VL  - 80
IS  - 6
M3  - Article
SP  - 675
EP  - 678
PB  - American Public Health Association
SN  - 00900036
AB  - Abstract: The importance of genetic influences on obesity has been emphasized recently. We conducted matched co-twin analyses of 250 pairs of White, male, monozygotic twins from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study. Entirely in the absence of genetic influences, obesity was significantly associated with systolic and diastolic blood pressures; one-hour, post-load glucose; total, LDL-, and HDL-cholesterol; and triglycerides among these 42-55 year old men. Similar results were obtained in longitudinal analyses of weight change during adulthood (from mean age of 20 to mean age of 48 years) and risk factor status at middle-age. These results indicate that behaviors and environmental exposures that occur later in life are responsible, at least in part, for the associations between adult obesity and cardiovascular disease risk, supporting the appropriateness of weight reduction efforts during adulthood. (Am J Public Health 1990; 80:675-678.) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OBESITY
KW  - TWINS
KW  - CARDIOVASCULAR diseases
KW  - DIABETES
KW  - DISEASES -- Risk factors
KW  - GENETIC disorders
KW  - METABOLIC disorders
KW  - BLOOD pressure
KW  - PUBLIC health
N1  - Accession Number: 4684913; Newman, Beth 1,2 Selby, Joseph V. 1 Qesenberry Jr., Charles P. 1 King, Mary-Claire 1,2 Friedman, Gary D. 1 Fabsitz, Richard R. 1,3; Affiliation:  1: Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA  2: University of California-Berkeley, School of Public Health  3: Clinical and Genetic Epidemiology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD; Source Info: Jun90, Vol. 80 Issue 6, p675; Subject Term: OBESITY; Subject Term: TWINS; Subject Term: CARDIOVASCULAR diseases; Subject Term: DIABETES; Subject Term: DISEASES -- Risk factors; Subject Term: GENETIC disorders; Subject Term: METABOLIC disorders; Subject Term: BLOOD pressure; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gallelli, J. F.;
AU  - Barletta, F. P.;
T1  - ROLE OF THE CLINICAL PHARMACIST IN THE CONDUCTING OF CLINICAL TRIALS
CT  - ROLE OF THE CLINICAL PHARMACIST IN THE CONDUCTING OF CLINICAL TRIALS
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1990/06/01/
VL  - 47
IS  - Jun
SP  - HH
EP  - 54
AD  - The Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
N1  - Accession Number: 27-08591; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice
N2  - The Clinical Center is a biomedical research hospital for the National Institutes of Health that admits patients solely for study in clinical trials. The role, services, and activities of the clinical pharmacist in the conducting of clinical trials will be presented. These will include membership on an institute's review board for protocols used in the clinical trials; reviewer of the drug therapy plans in the protocol; monitor of the patient's, nurse's, and physician's adherence to the protocol, such as drug doses, drug and laboratory values, and adverse drug reactions; assurer of patient compliance; and coordinator of the clinical trial's activities with the pharmaceutical manufacturer and the Food and Drug Administration.
KW  - ASHP meeting abstracts--clinical research programs;
KW  - Clinical studies--research--pharmacists role;
KW  - Clinical pharmacists--research--role;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Mccrae, Robert R.
T1  - Traits and trait names: how well is Openness represented in natural languages?
JO  - European Journal of Personality
JF  - European Journal of Personality
Y1  - 1990/06//
VL  - 4
IS  - 2
M3  - Article
SP  - 119
EP  - 129
PB  - John Wiley & Sons, Inc.
SN  - 08902070
AB  - The five-factor model of personality has repeatedly emerged from lexical studies of natural languages. When adjective-based factor scales are correlated with other personality measures, the adequacy and comprehensiveness of the five-factor model are demonstrated at a broad level. However, English language adjectives do not necessarily capture more subtle distinctions within the five factors. In particular, of several facets of the openness factor, only Openness to Ideas and Values are well represented in single terms. Openness to Fantasy, Aesthetics, Feelings, and Actions can be expressed in terms phrases, sentences, and literary passages-as excerpts from Bunin's Lika' Illustrate- but not in single words. To maintain its relevance to personality psychology, the study of personality language must continue to examine empirical links to other personality of personality systems and must move beyond the dictionary to analyses of natural language speech and writing. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Personality is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - ADJECTIVES (Grammar)
KW  - LEXICAL grammar
KW  - LITERATURE -- Psychology
KW  - AESTHETICS
KW  - EMOTIONS (Psychology)
N1  - Accession Number: 12076884; Mccrae, Robert R. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aping, National institutes of Health, Balomore. USA.; Source Info: Jun90, Vol. 4 Issue 2, p119; Subject Term: PERSONALITY; Subject Term: ADJECTIVES (Grammar); Subject Term: LEXICAL grammar; Subject Term: LITERATURE -- Psychology; Subject Term: AESTHETICS; Subject Term: EMOTIONS (Psychology); Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scheirer, Mary Ann
T1  - The Life Cycle of an Innovation: Adoption versus Discontinuation of the Fluoride Mouth Rinse Program in Schools.
JO  - Journal of Health & Social Behavior
JF  - Journal of Health & Social Behavior
Y1  - 1990/06//
VL  - 31
IS  - 2
M3  - Article
SP  - 203
EP  - 215
SN  - 00221465
AB  - Reasons for adoption and for discontinuation of a dental caries prevention innovation (the fluoride mouth rinse program) are examined by using recent theory on decision processes within organizations. Greer's (1977) analysis of three theoretical approaches for the study of innovation adoption—classical, organizational, and political—are used as an organizing framework to analyze these two parts of an overall life cycle for innovations. The results from both descriptive and multivariate analyses support the relevance of "political" and "classical" diffusion models for both adoption and discontinuation. Organizational structure variables— e.g., demographic indicators, administrative structures, and financial measures— show little explanatory strength for either outcome. Both outcomes seem to be dominated by "political" influences from strong interpersonal communications rather than by formal decision-making processes. The results suggest that political contingency theories may explain the processes by which organizations adopt and discontinue innovations, whereas classical diffusion theory explains the content of these processes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL caries -- Prevention
KW  - TEETH -- Care & hygiene
KW  - FLUORIDES
KW  - MULTIVARIATE analysis
KW  - SCHOOL health services
KW  - SCHOOL hygiene
KW  - THERAPEUTIC use
N1  - Accession Number: 12875218; Scheirer, Mary Ann 1; Affiliation:  1: National Institutes of Health; Source Info: Jun1990, Vol. 31 Issue 2, p203; Subject Term: DENTAL caries -- Prevention; Subject Term: TEETH -- Care & hygiene; Subject Term: FLUORIDES; Subject Term: MULTIVARIATE analysis; Subject Term: SCHOOL health services; Subject Term: SCHOOL hygiene; Subject Term: THERAPEUTIC use; Number of Pages: 13p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cooper, Kevin D.
AU  - Androphy, Elliot J.
AU  - Lowy, Douglas
AU  - Katz, Stephen I.
T1  - Antigen Presentation and T-Cell Activation in Epidermodysplasia Verruciformis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/06//
VL  - 94
IS  - 6
M3  - Article
SP  - 769
EP  - 776
SN  - 0022202X
AB  - Aberrant immune responses may play a role in the susceptibility of patients with epidermodysplasia verruciformis to human papilloma virus (HPV). We examined the stimulatory capacity of antigen-presenting cells from HPV-infected skin and peripheral blood T-cell responses of patients with epidermodysplasia verruciformis. The percentage of Langerhans cells in relation to total epidermal cells in suspension was slightly reduced in HPV-infected lesions, relative to apparently clinically uninfected epidermis. In addition, the morphologic appearance of Langerhans cells was altered in lesional epidermal sheets. Despite these abnormalities, Langerhans cells were functionally intact in their capacity to present alloantigens to T cells and, in fact, the epidermis of HPV-infected lesions demonstrated enhanced antigen- presenting activity in three of four patients tested. The antigen-presenting activity was entirely abrogated by removal of Langerhans cells and was not associated with increased activity of cytokines with stimulatory activity for the thymocyte co-stimulation assay. Although epidermodysplasia verruciformis T cells were unresponsive to autologous HPV-infected epidermis, they responded well to mitogens, allogeneic mononuclear leukocytes, and allogeneic epidermal cells. Epidermodysplasia verruciformis T cells were inhibited in their capacity to respond to allogeneic epidermal cells when they were simultaneously exposed to autologous epidermal cells from HPV-infected lesional epidermis, but not to normal-appearing epidermis. Thus, although Langerhans cell activity is intact in epidermodysplasia verruciformis, these individuals fail to respond to autologous papillomas, which may, at least in part, be explained by an interaction between papillomal epidermal cells and autologous T cells that results in an inhibited response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - PAPILLOMAVIRUSES
KW  - ANTIGENS
KW  - T cells
KW  - LANGERHANS cells
KW  - EPIDERMIS
N1  - Accession Number: 12874631; Cooper, Kevin D. 1,2 Androphy, Elliot J. 3 Lowy, Douglas 4 Katz, Stephen I. 4; Affiliation:  1: Immunodermatology Unit, Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.  2: Dermatology Service, Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan  3: Tufts New England Medical Center, Boston, Massachusetts, U.S.A.  4: National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Jun90, Vol. 94 Issue 6, p769; Subject Term: IMMUNE response; Subject Term: PAPILLOMAVIRUSES; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12874631
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Robledo, Mary Ann
AU  - Kim, Soo-Chan
AU  - Korman, Neil J.
AU  - Stanley, John R.
AU  - Labib, Ramzy S.
AU  - Futamura, Shozo
AU  - Anhalt, Grant J.
T1  - Studies of the Relationship of the 230-kD and 180-kD Bullous Pemphigoid Antigens.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/06//
VL  - 94
IS  - 6
M3  - Article
SP  - 793
EP  - 797
SN  - 0022202X
AB  - In bullous pemphigoid (BP), autoantibodies from most patients recognize a high molecular weight 230-kD epidermal antigen (Ag) by immunoprecipitation. By Western immunoblotting, 50-70% of sera recognize the high molecular weight Ag, but 30-50% recognize a low molecular weight, 180-kD epidermal Ag. We examined the speciflcities of affinity-puriuied antibodies against these Ag. Antibodies specific for the 230- and 180-kD Ag were prepared by immunoaffinity against Ag immobilized on nitrocellulose and released by acid glycine. IgG eluted from the 230-kD Ag band retained its specific binding to the 230-kD Ag by immuno-blotting, and bound to the epidermal basement membrane zone (BMZ) by indirect immunofluorescence (IF) and to hemidesmosomes by indirect immuno-electron microscopy (EM). IgG affinity purified by the 180-kD Ag band bound only the 180-kD Ag in immuno-blotting, with no cross reaction to the 230-kD Ag, bound the epidermal BMZ by indirect IF, and also bound to hemidesmosomes in immuno-EM. IgG specific for the 230-kD Ag in immunoblotting immunoprecipitated only the 230-kD Ag, with no apparent precipitation of the 180-kD Ag. Surprisingly, IgG specific for the 180-kD Ag precipitated both the 180- and the 230-kD Ag in immunoprecipitation, and the 230-kD Ag band was much more intense than the 180-kD Ag band. This study shows that apparent cross-reactivity between these Ag by BP autoantibodies can only be detected in native conditions by immunoprecipitation, and cannot be demonstrated using denatured Ag in immunoblotting. The two proteins appear to be distinct Ag, closely associated in the epidermal hemidesmosome, but the exact relationship of these Ag to each other may not be clarified until complete structural data become available. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOANTIBODIES
KW  - ANTIGENS
KW  - IMMUNOGLOBULINS
KW  - NITROCELLULOSE
KW  - GLYCINE
KW  - ELECTRON microscopy
N1  - Accession Number: 12874652; Robledo, Mary Ann 1 Kim, Soo-Chan 1 Korman, Neil J. 1 Stanley, John R. 1 Labib, Ramzy S. 1 Futamura, Shozo 1 Anhalt, Grant J. 1; Affiliation:  1: Department of Dermatology, Johns Hopkins University, Baltimore, and Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun90, Vol. 94 Issue 6, p793; Subject Term: AUTOANTIBODIES; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: NITROCELLULOSE; Subject Term: GLYCINE; Subject Term: ELECTRON microscopy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325211 Plastics Material and Resin Manufacturing; NAICS/Industry Codes: 325920 Explosives Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12874652
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Baker, Stuart G.
AU  - Chu, Kenneth C.
T1  - Evaluating Screening for the Early Detection and Treatment of Cancer Without Using a Randomized Control Group.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1990/06//
VL  - 85
IS  - 410
M3  - Article
SP  - 321
EP  - 327
SN  - 01621459
AB  - Sometimes the only data available for evaluating screening for the early detection and treatment of cancer come from studies lacking a randomized control group. To evaluate these data, various approaches have been proposed. They include constructing a model to estimate the duration of preclinical cancer and the sensitivity of the screen, formulating a model to estimate rates of cancer mortality, and using a nonrandomized control group to estimate age-specific incidence and mortality rates. These methods have various limitations. Either the estimated quantities are insufficient for a complete evaluation, strong parametric assumptions are required, or an assumption must be made that the nonrandomized control group yields unbiased estimates of cancer incidence. To bypass some of these limitations, a new method has been developed for analyzing screening data without a randomized control group. The method is called periodic screening evaluation (PSE) because it requires data from periodic screens rather than a single screen. Using weakly structured parametric models, PSE estimates the effect of screening on cancer mortality, using only data from persons offered screening PSE's major innovation is a technique for estimating age-specific cancer incidence using older screened persons as controls for younger screened persons. The limitations of PSE are often preferable to those associated with other methods. PSE's principal limitations are (a) use of a nonrandomized control group to estimate case-fatality rates in the absence of screening and (b) an assumption that, given a person's age, the year of birth adds no reformation for predicting cancer incidence PSE was applied to data on persons offered screening for the early detection and treatment of breast cancer in which a randomized control group not offered screening was available for validation. Using only data from persons offered screening, the probability of averting dearth from cancer due to starting periodic screening at various ages was estimated. Confidence intervals were large. Nevertheless, a fivefold increase in sample size, which probably would have been feasible without the constraints of a randomized trial would likely have yielded adequate precision. For validation purposes the cumulative number of observed deaths from cancer in the randomized control group was compared with the estimated cumulative number based on applying PSE only to women offered screening. The agreement was good. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXPECTATION-maximization algorithms
KW  - SURVIVAL analysis (Biometry)
KW  - MEDICAL screening
KW  - CANCER treatment
KW  - MEDICAL statistics
KW  - EM algorithm
KW  - Observational study
KW  - Survival analysis
N1  - Accession Number: 9705153235; Baker, Stuart G. 1; Chu, Kenneth C. 2; Affiliations: 1: Senior Staff Fellow, Screening Section, Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892; 2: Senior Investigator, Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892; Issue Info: Jun90, Vol. 85 Issue 410, p321; Subject Term: EXPECTATION-maximization algorithms; Subject Term: SURVIVAL analysis (Biometry); Subject Term: MEDICAL screening; Subject Term: CANCER treatment; Subject Term: MEDICAL statistics; Author-Supplied Keyword: EM algorithm; Author-Supplied Keyword: Observational study; Author-Supplied Keyword: Survival analysis; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 5877
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Kung-Yee Liang
AU  - Waclawiw, Myron
T1  - Extension of the Stein Estimating Procedure Through the Use of Estimating Functions.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1990/06//
VL  - 85
IS  - 410
M3  - Article
SP  - 435
EP  - 440
SN  - 01621459
AB  - This article extends the Stein method through the use of estimating functions (Godambe 1960) to address the simultaneous estimation of k population parameters, θi, ..., θk, in a mixed model setting. The procedure generalizes the Stein method by (a) allowing us to deal effectively with complications, such as inequality of population variances, that may arise in non-Gaussian mixed models, (b) being appropriate for estimating θ, in populations of varying sizes and, in particular, populations of small sizes, and (c) applying to situations where it cannot be assumed that the θ's have unbiased estimators or even estimators of finite moment. The focus of the article is on the quadratic variance function exponential family (Morris 1983b). Estimators for the parameters of the mixed model are developed in a regression model setting in which the θi's are allowed to vary with a vector of covariates. An application to incidence rates for the Iceland Breast Cancer Incidence Data is presented for illustrative purposes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - REGRESSION analysis
KW  - STATISTICS
KW  - PARAMETERS (Statistics)
KW  - POPULATION statistics
KW  - STATISTICAL bias
KW  - Conjugate prior
KW  - Empirical Bayes estimator
KW  - Exponential family
KW  - Maximum likelihood estimator
KW  - Mixed model
KW  - Score equation
KW  - Stein estimator
N1  - Accession Number: 9705153248; Kung-Yee Liang 1; Waclawiw, Myron 2; Affiliations: 1: Associate Professor, Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205; 2: Biostatistician, National Heart, Lung, and Blood Institute, Room 2-A-11, Federal Building, Bethesda, MD 20892; Issue Info: Jun90, Vol. 85 Issue 410, p435; Thesaurus Term: REGRESSION analysis; Thesaurus Term: STATISTICS; Subject Term: PARAMETERS (Statistics); Subject Term: POPULATION statistics; Subject Term: STATISTICAL bias; Author-Supplied Keyword: Conjugate prior; Author-Supplied Keyword: Empirical Bayes estimator; Author-Supplied Keyword: Exponential family; Author-Supplied Keyword: Maximum likelihood estimator; Author-Supplied Keyword: Mixed model; Author-Supplied Keyword: Score equation; Author-Supplied Keyword: Stein estimator; Number of Pages: 6p; Illustrations: 2 Graphs; Document Type: Article; Full Text Word Count: 6017
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Naoi, Michiko
AU  - Schooler, Carmi
T1  - Psychological Consequences of Occupational Conditions among Japanese Wives.
JO  - Social Psychology Quarterly
JF  - Social Psychology Quarterly
Y1  - 1990/06//
VL  - 53
IS  - 2
M3  - Article
SP  - 100
EP  - 116
SN  - 01902725
AB  - This paper examines how Japanese women's occupational conditions affect their psychological processes. We find that self-directed work increases their intellectual flexibility and the self-directedness of their orientations; this finding replicates earlier findings about these important psychological outcomes of self-directed work, even in a culture where self-directedness for women is particularly disvalued culturally. Self-directed work also leads to less traditional attitudes towards the elderly, whereas working in a traditional industry makes such attitudes more traditional. This finding shows that Japanese women's work experiences can affect even their acceptance of traditional norms. Our evidence also shows that Japanese women are substantially less likely than their husbands to do self-directed work on the job. The resultant occupationally induced lessening of self-directed orientation may contribute to women's accepting cultural norms that keep them in subservient positions. Thus the culturally and social structurally determined occupational experiences of Japanese women clearly affect how they confront major social and personal problems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Psychology Quarterly is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INDUSTRIAL psychologists
KW  - AUTONOMY (Psychology)
KW  - WOMEN employees
KW  - SOCIAL norms
KW  - SOCIAL structure
KW  - APPRENTICES
N1  - Accession Number: 13666100; Naoi, Michiko 1 Schooler, Carmi 2; Affiliation:  1: Tokyo Gakugei University.  2: National Institute of Mental Health.; Source Info: Jun90, Vol. 53 Issue 2, p100; Subject Term: INDUSTRIAL psychologists; Subject Term: AUTONOMY (Psychology); Subject Term: WOMEN employees; Subject Term: SOCIAL norms; Subject Term: SOCIAL structure; Subject Term: APPRENTICES; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1991-00611-001
AN  - 1991-00611-001
AU  - Barth, Timothy M.
AU  - Jones, Theresa A.
AU  - Schallert, Timothy
T1  - Functional subdivisions of the rat somatic sensorimotor cortex.
JF  - Behavioural Brain Research
JO  - Behavioural Brain Research
JA  - Behav Brain Res
Y1  - 1990/06//
VL  - 39
IS  - 1
SP  - 73
EP  - 95
CY  - Netherlands
PB  - Elsevier Science
SN  - 0166-4328
N1  - Accession Number: 1991-00611-001. PMID: 2390194 Partial author list: First Author & Affiliation: Barth, Timothy M.; NIMH Lab of Neurophysiology, National Institutes of Health Animal Ctr, Poolesville, MD, US. Release Date: 19910101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior; Motor Cortex; Somatosensory Cortex. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Page Count: 23. Issue Publication Date: Jun, 1990. 
AB  - Studied behavioral impairments and subsequent recovery in male rats with circumscribed unilateral lesions in the somatic sensorimotor cortex (SMC). Lesions were made in the caudal forelimb region (CFL), the rostral forelimb region (RFL), the anteromedial cortex (AMC), or the hindlimb area. Ss with damage in the CFL produced a deficit in placing the forelimb contralateral to the lesion during exploratory locomotion on a grid surface. Ss with AMC damage circled in the direction ipsilateral to the lesion. Lesions in the CFL or AMC produced an ipsilateral somatosensorimotor asymmetry on a bilateral stimulation test that recovered 7 days following AMC lesions or 28 days following CFL lesions. Ss receiving 2-stage bilateral lesions in the RFL or CFL responded slower to tactile stimulation of the forelimb contralateral to the 2nd lesion. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - circumscribed regional unilateral lesions of somatic sensorimotor cortex
KW  - behavioral impairments & recovery
KW  - male rats
KW  - 1990
KW  - Behavior
KW  - Motor Cortex
KW  - Somatosensory Cortex
KW  - Rats
KW  - 1990
DO  - 10.1016/0166-4328(90)90122-U
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Caughman, S. Wright
AU  - Lian-Jie, Li
AU  - Degitz, Klaus
T1  - Characterization and Functional Analysis of Interferon-γ-Induced Intercellular Adhesion Molecule-1 Expression in Human  Keratinocytes and A-431 Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/06/15/Jun90 Supplement
VL  - 94
M3  - Article
SP  - 22s
EP  - 26s
SN  - 0022202X
AB  - Human intercellular adhesion molecule-1 (ICAM-1) is a cell-surface glycoprotein that serves as one of the major ligands for lymphocyte function-associated antigen-1 (LFA-1), a member of the integrin supergene family of adhesion molecules that is involved in cell-cell adhesion. Homotypic and heterotypic conjugate formation between leukocytes and between leukocytes and target cells via the LFA-1/ICAM-1 interaction has been demonstrated to be a critical event in numerous immunologic and inflammatory processes. While LFA-1 is expressed by all leukocytes, ICAM-1 is not normally expressed by all tissues with which leukocytes interact, but ICAM-1 may be induced de novo by various cytokines, including interferon-γ (IFN-γ). The constitutive and IFN-γ-induced expression and function of ICAM-1 in human keratinocytes (HK) and A-431 cells in culture has been analyzed. While A-431 cells constitutively express ICAM-1 when assessed by northern blotting, by biosynthetic labeling and immunoprecipitation, and by flow cytometry, HK do not. When these two cell types are exposed to recombinant human (rh-) IFN-γ at 1000 U/ml for 24 h, A-431 cells upregulate ICAM-1 and HK express ICAM-1 to an equal degree when assessed by these same parameters. Furthermore, in an in vitro adhesion assay, rh-IFN-γ treatment of the HK or A-431 cells greatly increases the specific adherence of radiolabeled T cells to these cells. These data provide further evidence for the potential role of the regulated expression of ICAM- 1 by keratinocytes in immunologic and inflammatory responses occurring in the skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERFERONS
KW  - GAMMA particle (Cytology)
KW  - CELL adhesion molecules
KW  - KERATINOCYTES
KW  - GLYCOPROTEINS
KW  - CELL adhesion
N1  - Accession Number: 12875005; Caughman, S. Wright 1 Lian-Jie, Li 1 Degitz, Klaus 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun90 Supplement, Vol. 94, p22s; Subject Term: INTERFERONS; Subject Term: GAMMA particle (Cytology); Subject Term: CELL adhesion molecules; Subject Term: KERATINOCYTES; Subject Term: GLYCOPROTEINS; Subject Term: CELL adhesion; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12875005
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Górski, Tadeusz
AU  - Goehl, Thomas
AU  - Jameson, C.
AU  - Collins, Bradley
T1  - Sources of error in the determination of trichloroethylene in blood.
JO  - Bulletin of Environmental Contamination & Toxicology
JF  - Bulletin of Environmental Contamination & Toxicology
Y1  - 1990/07//
VL  - 45
IS  - 1
M3  - Article
SP  - 1
EP  - 5
SN  - 00074861
AB  - The article presents a study regarding the determination of volatile analyte trichloroethylene (TCE). The study used gas chromatography, experiments in water and blood samples to determine TCE recovery, and tuberculin syringe. Results showed that there was excellent recovery and high precision in the determination of TCE in whole blood samples but TCE concentration in red blood cells (RBC) was higher by roughly 20% than in whole blood.
KW  - RESEARCH
KW  - Gas chromatography
KW  - Trichloroethylene
KW  - Experiments
KW  - Blood
KW  - Syringes
KW  - Erythrocytes
N1  - Accession Number: 70789685; Górski, Tadeusz 1; Goehl, Thomas 1; Jameson, C. 1; Collins, Bradley 1; Affiliations: 1: National Toxicology Program, National Institute of Environmental Health Sciences, 27709 Research Triangle Park USA; Issue Info: Jul1990, Vol. 45 Issue 1, p1; Thesaurus Term: RESEARCH; Thesaurus Term: Gas chromatography; Subject Term: Trichloroethylene; Subject Term: Experiments; Subject Term: Blood; Subject Term: Syringes; Subject Term: Erythrocytes; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1007/BF01701820
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
T1  - CONTROLLING NEUROTICISM IN THE MEASUREMENT OF STRESS.
AU  - McCrae, Robert R.
JO  - Stress Medicine
JF  - Stress Medicine
Y1  - 1990/07//Jul/Sep90
VL  - 6
IS  - 3
SP  - 237
EP  - 241
SN  - 07488386
N1  - Accession Number: 12057473; Author: McCrae, Robert R.: 1 ; Author Affiliation: 1 Gerontology Research Center, National Institute on Aging, National Institutes of Health, 4940 Easten Avenue, Baltimore, MA 21224, USA; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20040127
N2  - To assess stress — the demands place on the individual by his or her environment — life-event checklists and lists of daily hassles have been widely used. Such instruments are intended to reflect harmful, threatening, or challenging aspects of the environment, but they are likely to be strongly influenced by characteristics of the respondent, especially the personality disposition of neuroticism. Individuals high on this dimension perceive life as stressful cope poorly, are dissatisfied with social supports, have low psychological well-being, and make more somatic complaints. Relations among these variables may be due to the common influence of neuroticism rather than processes of stress and coping. Longitudinal designs and objective outcome measures can reduce the confounding effects of neuroticism. By including measures of neuroticism in their designs, researchers can increase their understanding of the mutual roles of stress and personality in determining mental and physical health. By measuring neuroticism in their clients, stress management practitioners can gain insight into the reports of stressful events and conditions their clients make. ABSTRACT FROM AUTHOR
KW  - *NEUROSES
KW  - *STRESS (Psychology)
KW  - *MENTAL depression
KW  - *PERSONALITY
KW  - *HEALTH
KW  - *MENTAL health
KW  - *PSYCHOLOGY
KW  - *WELL-being
KW  - LIFE change events
KW  - PERSONALITY disorders
KW  - HUMAN behavior
KW  - ADJUSTMENT (Psychology)
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
AU  - Riley, Matilda White
T1  - THE INFLUENCE OF SOCIOLOGICAL LIVES: PERSONAL REFLECTIONS.
JO  - Annual Review of Sociology
JF  - Annual Review of Sociology
Y1  - 1990/08//
VL  - 16
M3  - Article
SP  - 1
EP  - 25
PB  - Annual Reviews Inc.
SN  - 03600572
AB  - In contrast to the well-established influence of social change on sociological lives, the author develops a theory of the influence exerted by the lives and experiences of sociologists on social and intellectual structure and change, both in sociology and in society as a whole. Writing in a semi-autobiographical vein, she uses as examples of this influence fragments from her earlier writings in four areas of current sociological concern: sociological practice, gender, age, and dynamic social systems. These fragments are interwoven with anecdotal accounts of experiences from the lives of well-known sociologists and the author herself, spanning much of the twentieth century. While giving a flavor of her own contributions and also several thwarted attempts, these reflections illustrate how the degree of sociological influence depends on the mesh between the attributes of particular lives and the opportunities afforded at the time by the state of the discipline and of society. Several types of historical structures and changes are identified as either facilitating or hindering the flow of influence, including trends in sociological thought and methods of research, ideologies and values paramount in the discipline, and social and cultural changes in society as a whole. For the future, the question raised is how, in a rapidly changing world, to identify channels for exercising influence on sociology as well as on public policy and professional practice. The concluding hope is that other sociologists may be sensitized to a self-conscious awareness of the special opportunities for influence available in the unique historical era in which their lives unfold. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annual Review of Sociology is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL change
KW  - GENDER
KW  - INFLUENCE (Psychology)
KW  - SOCIOLOGY
KW  - SOCIAL history
KW  - age
KW  - dynamic systems
KW  - gender
KW  - influence
KW  - lives
KW  - sociological practice
N1  - Accession Number: 9101282644; Riley, Matilda White 1; Affiliation:  1: National Institute on Aging, National Institutes of Health Building 31C, Room 5C32, Bethesda, Maryland 20892; Source Info: 1990, Vol. 16, p1; Subject Term: SOCIAL change; Subject Term: GENDER; Subject Term: INFLUENCE (Psychology); Subject Term: SOCIOLOGY; Subject Term: SOCIAL history; Author-Supplied Keyword: age; Author-Supplied Keyword: dynamic systems; Author-Supplied Keyword: gender; Author-Supplied Keyword: influence; Author-Supplied Keyword: lives; Author-Supplied Keyword: sociological practice; Number of Pages: 25p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sandrock, Dirk
AU  - Merino, Maria
AU  - Norton, Jeffrey
AU  - Neumann, Ronald
T1  - Parathyroid imaging by Tc/TI scintigraphy.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1990/08//
VL  - 16
IS  - 8-10
M3  - Article
SP  - 607
EP  - 613
SN  - 03406997
N1  - Accession Number: 71154378; Sandrock, Dirk 1 Merino, Maria 2 Norton, Jeffrey 3 Neumann, Ronald 1; Affiliation:  1: Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda USA  2: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda USA  3: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda USA; Source Info: Aug1990, Vol. 16 Issue 8-10, p607; Number of Pages: 7p; Document Type: Article
L3  - 10.1007/BF00998157
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Oliveri, Mary Ellen
T1  - Handbook of Family Measurement Techniques (Book).
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1990/08//
VL  - 52
IS  - 3
M3  - Book Review
SP  - 799
EP  - 800
SN  - 00222445
AB  - Reviews the book "Handbook of Family Measurement Techniques," edited by John Touliatos, Barry F. Perlmutter and Murray A. Straus.
KW  - FAMILIES
KW  - NONFICTION
KW  - TOULIATOS, John
KW  - PERLMUTTER, Barry F.
KW  - STRAUS, Murray A.
KW  - HANDBOOK of Family Measurement Techniques (Book)
N1  - Accession Number: 9604085999; Oliveri, Mary Ellen 1; Affiliation:  1: National Institute of Mental Health; Source Info: Aug90, Vol. 52 Issue 3, p799; Subject Term: FAMILIES; Subject Term: NONFICTION; Reviews & Products: HANDBOOK of Family Measurement Techniques (Book); People: TOULIATOS, John; People: PERLMUTTER, Barry F.; People: STRAUS, Murray A.; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 576
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hill, S. A.
AU  - Morrison, S. G.
AU  - Swanson, J.
T1  - The role of direct oligonucleotide repeats in gonococcal pilin gene variation.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1990/08//
VL  - 4
IS  - 8
M3  - Article
SP  - 1341
EP  - 1352
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Previous studies indicate that gonococcal pilin phase and antigenic variation occur by intragenomic pilin gene recombination, the outcome of which resembles that of gene conversion. During such transitions, the expressed complete pilin gene (<em>pilE</em>) acquires a novel sequence corresponding to that of a silent pilin gene (<em>pilS</em>). In the present study, we find that internal deletions of <em>pilE</em> can produce pilus-/pilus+ phase transitions: direct oligonucleotide repeats in the pilin-encoding portion of <em>pilE</em> bracket the deleted segments. A novel, orthodox <em>pilE</em> is formed upon repair of the internal deletions, with <em>pilS</em> sequence probably acting as a template for repair. Such deletion/repair of <em>pilE</em> is suggested as a principal mechanism underlying gonococcal pilus variation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Antigenic determinants
KW  - Genomics
KW  - Molecular genetics
KW  - Genes
KW  - Oligonucleotides
KW  - Nucleotides
KW  - Neisseria gonorrhoeae
N1  - Accession Number: 15944815; Hill, S. A. 1; Morrison, S. G. 1; Swanson, J. 1; Affiliations: 1: Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamiiton, Montana 59840, USA; Issue Info: Aug1990, Vol. 4 Issue 8, p1341; Subject Term: Antigenic determinants; Subject Term: Genomics; Subject Term: Molecular genetics; Subject Term: Genes; Subject Term: Oligonucleotides; Subject Term: Nucleotides; Subject Term: Neisseria gonorrhoeae; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 12p; Illustrations: 9 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104745153
T1  - Towards physiologically based treatment of patients with neuropathic pain.
AU  - Max, M B
Y1  - 1990/08//1990 Aug
N1  - Accession Number: 104745153. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Nervous System Diseases -- Physiopathology
KW  - Palliative Care -- Methods
KW  - Analgesics -- Therapeutic Use
KW  - Animals
KW  - Clinical Trials
KW  - Nervous System Diseases -- Classification
KW  - Pain
KW  - Pain Measurement -- Methods
KW  - Paroxetine
KW  - Piperidines -- Therapeutic Use
SP  - 131
EP  - 137
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 42
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20852.
U2  - PMID: 1701044.
DO  - 10.1016/0304-3959(90)91156-D
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Stocker, Joyce
AU  - Liegey, Claudine
AU  - Cooley, Deborah
AU  - Nagle, Sigrid
T1  - Patient's Advocate: When little more could be done, we did a lot.
JO  - RN
JF  - RN
Y1  - 1990/08//
VL  - 53
IS  - 8
M3  - Article
SP  - 25
EP  - 101
SN  - 00337021
AB  - Deals with the case of a patient diagnosed with mycosis fungoides, a cutaneous T-cell lymphoma.  Experiences of nurses assigned to give care to the patient; Description of the condition of the patient; Reaction of nurses to the death of the patient.
KW  - MYCOSIS fungoides
KW  - NURSE & patient
N1  - Accession Number: 4939522; Stocker, Joyce 1; Liegey, Claudine 2; Cooley, Deborah 2; Nagle, Sigrid; Source Information: Aug90, Vol. 53 Issue 8, p25; Subject: MYCOSIS fungoides; Subject: NURSE & patient; Number of Pages: 3p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 1080
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Leukefeld, Carl G.
AU  - Battjes, Robert J.
AU  - Amsel, Zili
T1  - CRITICAL REVIEWS: COMMUNITY PREVENTION EFFORTS TO REDUCE THE SPREAD OF AIDS ASSOCIATED WITH INTRAVENOUS DRUG ABUSE.
JO  - AIDS Education & Prevention
JF  - AIDS Education & Prevention
Y1  - 1990///Fall1990
VL  - 2
IS  - 3
M3  - Article
SP  - 235
EP  - 243
SN  - 08999546
AB  - The article focuses on the community prevention efforts to reduce the intravenous drug abuse-related AIDS transmission in the U.S. Significantly, almost 30% of AIDS cases reported by the Centers for Disease Control and Prevention are caused by drug abuse. Furthermore, HIV transmission has been attributed to intravenous drug users. Moreover, the prevention of AIDS transmission is a top priority considering the high levels of AIDS risk behaviors among drug users. Recommendations have been developed by researchers who convened at the National Institute on Drug Abuse wherein community prevention is an important AIDS reduction strategy. The introduction of the strategy aims for community prevention with intravenous drug users and their sex partners along with suggested research programs.
KW  - AIDS (Disease)
KW  - Health risk assessment
KW  - Intravenous drug abuse
KW  - PREVENTION
KW  - Sexually transmitted diseases
KW  - Community health services
KW  - Public health administration
KW  - Health services administration
KW  - United States
KW  - Centers for Disease Control & Prevention (U.S.)
N1  - Accession Number: 19682606; Leukefeld, Carl G. 1; Battjes, Robert J. 2; Amsel, Zili 2; Affiliations: 1: Deputy Director, Division of Clinical Research, National Institute on Drug Abuse; 2: National Institute on Drug Abuse; Issue Info: Fall1990, Vol. 2 Issue 3, p235; Thesaurus Term: AIDS (Disease); Thesaurus Term: Health risk assessment; Subject Term: Intravenous drug abuse; Subject Term: PREVENTION; Subject Term: Sexually transmitted diseases; Subject Term: Community health services; Subject Term: Public health administration; Subject Term: Health services administration; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - NEWS
AU  - Henningfield, Jack E.
T1  - Can Genetic Constitution Affect the "Objective" Diagnosis of Nicotine Dependence?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/09//
VL  - 80
IS  - 9
M3  - Editorial
SP  - 1040
EP  - 1041
PB  - American Public Health Association
SN  - 00900036
AB  - The article reflects on the issue which asks if genetic constitution can affect the positive diagnosis of nicotine dependence. It mentions that precise diagnosis of dependence in nicotine and detection of relapse in treated tobacco dependent persons can be compensated by quantitative biochemical evaluation.
KW  - NICOTINE
KW  - ALKALOIDS
KW  - PYRIDINE
KW  - TOBACCO
N1  - Accession Number: 9101281077; Henningfield, Jack E. 1; Affiliation:  1: Clinical Pharmacology Branch, Addiction Research Center, National Institute on Drug Abuse, P.O. Box 5180 (or 4940 Eastern Avenue), Baltimore, MD 21224; Source Info: Sept90, Vol. 80 Issue 9, p1040; Subject Term: NICOTINE; Subject Term: ALKALOIDS; Subject Term: PYRIDINE; Subject Term: TOBACCO; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wagenknecht, Lynne E.
AU  - Cutter, Gary R.
AU  - Haley, Nancy J.
AU  - Sidney, Steve
AU  - Manolio, Teri A.
AU  - Hughes, Glenn H.
AU  - Jacobs, David R.
T1  - Racial Differences in Serum Cotinine Levels Among Smokers in the Coronary Artery Risk Development in (Young) Adults Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/09//
VL  - 80
IS  - 9
M3  - Article
SP  - 1053
EP  - 1056
PB  - American Public Health Association
SN  - 00900036
AB  - Cotinine was measured in the serum of nearly all 5, 115 18-30 year old, Black and White, men and women participating in the Coronary Artery Risk Development in (Young) Adults Study, 30 percent of whom reported current cigarette smoking. Ninety-five percent of the reported smokers had serum cotinine levels indicative of smoking (> 13 ng/ml). The median cotinine level was higher in Black than White Smokers (221 ng/ml versus 170 ng/ml; 95 percent CI for difference: 34,65) in spite of the fact that estimated daily nicotine exposure and serum thiocyanate were higher in Whites. The difference persisted after controlling for number of cigarettes, nicotine, content, frequency of inhalation, weekly sidestream smoke exposure, age gender, and education. A reporting bias and nicotine intake were ruled out as explanations for the racial difference suggesting that the metabolism of nicotine or the excretion of cotinine may differ by race. Racial differences in cotinine levels may provide clues to the reasons for the observed lower cessation rates and higher rates of some smoking-related caners in Blacks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIGARETTE smokers
KW  - RACIAL differences
KW  - SERUM
KW  - CORONARY arteries
KW  - HEART -- Blood-vessels
KW  - ARTERIES
KW  - YOUNG adults
KW  - SMOKING
KW  - NICOTINE
N1  - Accession Number: 9101281026; Wagenknecht, Lynne E. 1,2 Cutter, Gary R. 3 Haley, Nancy J. 4 Sidney, Steve 5 Manolio, Teri A. 6 Hughes, Glenn H. 7 Jacobs, David R. 8; Affiliation:  1: CARDIA Coordinating Center, Medical Towers Building, Room 504, 1717 11th Avenue South, Birmingham, AL, 35205  2: Department of Epidemiology, University of Alabama, Birmingham School of Public Health  3: Biostatistics and Information Systems Division, St. Jude Children's Research Hospital, Memphis, TN  4: Division of Nutrition and Endocrinology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY  5: Division of Research, Kaiser Permanente Medical Care Program (Northern California Region), Oakland, CA  6: Division of Epidemiology and Clinical Application, National Heart, Lund and Blood Institute, National Institutes of Health, Bethesda, MD  7: Department of General and Preventive Medicine, Behavioral Medicine Unit, University of Alabama, Birmingham  8: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN; Source Info: Sept90, Vol. 80 Issue 9, p1053; Subject Term: CIGARETTE smokers; Subject Term: RACIAL differences; Subject Term: SERUM; Subject Term: CORONARY arteries; Subject Term: HEART -- Blood-vessels; Subject Term: ARTERIES; Subject Term: YOUNG adults; Subject Term: SMOKING; Subject Term: NICOTINE; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Miller, F. W.
AU  - Love, L. A.
AU  - Barbieri, S. A.
AU  - Balow, J. E.
AU  - Plotz, P. H.
T1  - Lymphocyte activation markers in idiopathic myositis: changes with disease activity and differences among clinical and autoantibody subgroups.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1990/09//
VL  - 81
IS  - 3
M3  - Article
SP  - 373
EP  - 379
PB  - Wiley-Blackwell
SN  - 00099104
AB  - We studied the immunologic correlates of disease activity and differences among subgroups of patients with idiopathic inflammatory myopathy by analysing phenotypic and activation marker expression on peripheral blood mononuclear cells (PBMC). Compared with controls, myositis patients with clinically active disease (n= 51) had significantly lower proportions of CD8+ cells and higher proportions of PBMC that expressed DR. CD3- DR. CD14- DR, interleukin-2 receptors, and the late T cell activation markers CD26 and TLiSA1. TLiISA1 expressions marker for cytotoxic differentiation, correlated significantly with both clinical activity indices and serum levels of muscle- associated enzymes. in serial studies of seven patients, the proportion of PBMC expressing MHC class It antigen and late T cell activation markers decreased as myositis disease activity decreased, independent of type of therapy. Among the clinical subgroups. polymyositis (n= 21) and inclusion body myositis (n= 11) were virtually indistinguishable; dermatomyositis patients (n = 19) showed decreased proportions of CD3+ DR+ and TLiSA1+ cells, and increased proportions of CD20+ and CD20+DR+ cells compared with the other two groups. Patients with autoantibodies to histidyl-tRNA synthetase (Jo-1 antigen, n = 11) had significantly lower proportions of CD3+ and CD4+ cells, lower CD4/CD8 ratios, and higher proportions of DR+ cells expressing CD20, compared with patients without anti-Jo-1 antibodies. These findings support the concept that activated lymphocytes, especially cells undergoing anamnestic responses and cytotoxic differentiation. are important in the pathogenesis of idiopathic myositis. Moreover, taken together with other studies, these data suggest that groups of patients segregated by clinical or autoantibody status have different mechanisms of systemic immune activation and immunopathology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOCYTES
KW  - INTERLEUKIN-2
KW  - T cells
KW  - ANTIGENS
KW  - LEUCOCYTES
KW  - CELLULAR immunity
KW  - activation
KW  - anti-Jo-I
KW  - idiopathic
KW  - inflammatory
KW  - lymphocyte
KW  - markers
KW  - myopathy
KW  - polymyositis
N1  - Accession Number: 15985326; Miller, F. W. 1 Love, L. A. 1 Barbieri, S. A. 2 Balow, J. E. 2 Plotz, P. H. 1; Affiliation:  1: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.  2: Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Sep1990, Vol. 81 Issue 3, p373; Subject Term: LYMPHOCYTES; Subject Term: INTERLEUKIN-2; Subject Term: T cells; Subject Term: ANTIGENS; Subject Term: LEUCOCYTES; Subject Term: CELLULAR immunity; Author-Supplied Keyword: activation; Author-Supplied Keyword: anti-Jo-I; Author-Supplied Keyword: idiopathic; Author-Supplied Keyword: inflammatory; Author-Supplied Keyword: lymphocyte; Author-Supplied Keyword: markers; Author-Supplied Keyword: myopathy; Author-Supplied Keyword: polymyositis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Haertzen, Charles A.
AU  - Hickey, John E.
AU  - Rose, Marc R.
AU  - Jaffe, Jerome H.
T1  - THE RELATIONSHIP BETWEEN A DIAGNOSIS OF ANTISOCIAL PERSONALITY AND HOSTILITY: DEVELOPMENT OF AN ANTISOCIAL HOSTILITY SCALE.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1990/09//
VL  - 46
IS  - 5
M3  - Article
SP  - 679
EP  - 686
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - An antisocial hostility scale was developed by correlating items of the Buss-Durkee Hostility Inventory with a diagnosis of Antisocial Personality (ASP). Fifty two male volunteers for drug related studies at the Addiction Research Center were used for a preliminary test development sample. The scale developed thereby was related significantly to a diagnosis of antisocial personality in a cross validation sample of 28 drug abusers. A final scale was developed by obtaining correlations between ASP and Buss-Durkee items using subjects from both of these preliminary samples.
KW  - ANTISOCIAL personality disorders
KW  - HOSTILITY (Psychology)
KW  - PERSONALITY disorders
KW  - MALES
KW  - ATTITUDE (Psychology)
KW  - AGGRESSION (Psychology)
N1  - Accession Number: 11991462; Haertzen, Charles A. 1 Hickey, John E. 1 Rose, Marc R. 1 Jaffe, Jerome H. 1; Affiliation:  1: Addiction Research Center, Alcohol Drug Abuse and Mental Health Administration, National Institute on Drug Abuse.; Source Info: Sep1990, Vol. 46 Issue 5, p679; Subject Term: ANTISOCIAL personality disorders; Subject Term: HOSTILITY (Psychology); Subject Term: PERSONALITY disorders; Subject Term: MALES; Subject Term: ATTITUDE (Psychology); Subject Term: AGGRESSION (Psychology); Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Follmann, Dean A.
AU  - Goldberg, Matthew S.
AU  - May, Laurie
AD  - National Heart Lung and Blood Institute
AD  - Institute for Defense Analyses
AD  - Center for Naval Analyses
T1  - Personal Characteristics, Unemployment Insurance, and the Duration of Unemployment
JO  - Journal of Econometrics
JF  - Journal of Econometrics
Y1  - 1990/09//
VL  - 45
IS  - 3
SP  - 351
EP  - 366
N1  - Accession Number: 0239206; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199103
N2  - This paper develops a methodology to accommodate the "spikes" in reemployment probabilities that are observed when unemployment insurance expires. Previous studies apply the Cox regression model, which has the advantage of a nonparametric baseline hazard function. However, even the Cox model constrains the explanatory variables to have the same effect throughout the entire spell of unemployment. By contrast, the authors' new model allows the explanatory variables to have different effects at and away from the spike. After a simple data transformation, their model may be estimated using readily available software. An empirical example is provided, and generalizations are discussed.
KW  - Econometric and Statistical Methods and Models--General          2110
KW  - Unemployment Insurance          8224
KW  - Employment Studies; Unemployment and Vacancies; Retirements and Quits          8243
L3  - http://www.sciencedirect.com/science/journal/03044076
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UR  - http://www.sciencedirect.com/science/journal/03044076
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Yanagawa, Takashi
AU  - Fujii, Yoshinori
T1  - Homogeneity Test With a Generalized Mantel-Haenszel Estimator for L2 Χ K Contingency Tables.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1990/09//
VL  - 85
IS  - 411
M3  - Article
SP  - 744
EP  - 748
SN  - 01621459
AB  - A conditional test for the homogeneity of the odds ratios in L2 x K (K > 2) tables is developed based on a multiple hypergeometric distribution. The test is a generalization of the Breslow-Day test (1980) and is useful in sparse tables. For computational feasibility, the conditional maximum likelihood estimator is replaced by a consistent but inefficient estimator in the test statistic. If this is the case, it is shown that the asymptotic distribution is not chi squared, as has been noticed by Tarone (1985) in the case of 2 x 2 tables. Following Tarone we develop a correction method so that the statistic follows an asymptotic chi-squared distribution. An algorithm is developed for calculating the homogeneity test with a generalized Mantel-Haenszel estimator. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESTIMATION theory
KW  - ALGORITHMS
KW  - HYPERGEOMETRIC functions
KW  - CHI-squared test
KW  - ASYMPTOTIC expansions
KW  - Conditional test
KW  - Second-order interaction
KW  - Sparse table
KW  - Three-way contingency table
N1  - Accession Number: 9705180995; Yanagawa, Takashi 1,2; Fujii, Yoshinori 3; Affiliations: 1: Visiting Scientist, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 2770; 2: Associate Professor, Department of Mathematics, Kyushu University 33, Fukuoka 812, Japan; 3: Assistant Professor, Department of Mathematics, Faculty of Education, Miyazaki University, Miyazaki 889-21, Japan; Issue Info: Sep90, Vol. 85 Issue 411, p744; Thesaurus Term: ESTIMATION theory; Thesaurus Term: ALGORITHMS; Subject Term: HYPERGEOMETRIC functions; Subject Term: CHI-squared test; Subject Term: ASYMPTOTIC expansions; Author-Supplied Keyword: Conditional test; Author-Supplied Keyword: Second-order interaction; Author-Supplied Keyword: Sparse table; Author-Supplied Keyword: Three-way contingency table; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Brown, Martin L.
AU  - Potosky, Arnold L.
T1  - THE PRESIDENTIAL EFFECT: THE PUBLIC HEALTH RESPONSE TO MEDIA COVERAGE ABOUT RONALD REAGAN'S COLON CANCER EPISODE.
JO  - Public Opinion Quarterly
JF  - Public Opinion Quarterly
Y1  - 1990///Fall90
VL  - 54
IS  - 3
M3  - Article
SP  - 317
EP  - 329
SN  - 0033362X
AB  - Little previous research has been done on the public health impact of mass media coverage of cancer episodes of public figures. This paper uses a variety of data sources to examine the impact of President Reagan's colon cancer episode of July, 1985. Records of phone calls to the Cancer information Service of the National Cancer institute are examined as a measure of public interest and concern about colorectal cancer: data on the use of two colorectal early detection tests-proctoscopy and fecal occult blood tests-are looked at as a measure of behavioral change: and data on the incidence of early and advanced colorectal cancer are used to estimate the potential public health impact of this behavioral change. We find that there was a sharp, albeit somewhat transitory, increase in public interest in colorectal cancer in the wake of President Reagan's colon cancer episode, with a corresponding increase in the use of early detection tests. The incidence data on early and advanced disease is indicative of a beneficial public health impact. but this can be confirmed only after additional data on mortality becomes available. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PUBLIC health
KW  - MASS media
KW  - COLON cancer
KW  - HUMAN behavior
KW  - MORTALITY
KW  - REAGAN, Ronald, 1911-2004
N1  - Accession Number: 12221757; Brown, Martin L. 1 Potosky, Arnold L. 2; Affiliation:  1: Economist, Applied Research Branch, Surveillance Program, Division of Cancer Prevention and Control, National Cancer Institute.  2: Operations Research Analyst, Applied Research Branch, Surveillance Program, Division of Cancer Prevention and Control, National Cancer Institute.; Source Info: Fall90, Vol. 54 Issue 3, p317; Subject Term: PUBLIC health; Subject Term: MASS media; Subject Term: COLON cancer; Subject Term: HUMAN behavior; Subject Term: MORTALITY; NAICS/Industry Codes: 525120 Health and Welfare Funds; People: REAGAN, Ronald, 1911-2004; Number of Pages: 13p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fahey, Barbara J.
AU  - Magnuson, Warren G.
AU  - Henderson, David K.
AU  - Fahey, B J
AU  - Henderson, D K
T1  - Minimizing risks for occupational blood-borne infections.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/09/05/
VL  - 264
IS  - 9
M3  - journal article
SP  - 1189
EP  - 1189
SN  - 00987484
AB  - Discusses strategies for health care workers in the U.S. to minimize the risks for occupational blood-borne infections.  Percentage of health care workers at risk for occupational hepatitis B virus infection; Impact of the risk of HIV infection on medical students; Modification of health care worker behavior to minimize the risks for occupational blood-borne infections.
KW  - BLOODBORNE infections
KW  - COMMUNICABLE diseases -- Transmission
KW  - INFECTION
KW  - MEDICAL personnel
KW  - MEDICAL students
N1  - Accession Number: 10418791; Fahey, Barbara J. Magnuson, Warren G. Henderson, David K. Fahey, B J 1 Henderson, D K; Affiliation:  1: Warren G. Magnuson Clinical Center, National Institutes of Health; Source Info: 9/5/90, Vol. 264 Issue 9, p1189; Subject Term: BLOODBORNE infections; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: INFECTION; Subject Term: MEDICAL personnel; Subject Term: MEDICAL students; Number of Pages: 2p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chambless, Lloyd E.
AU  - Fuchs, Flavio D.
AU  - Linn, Shai
AU  - Kritchevsky, Stephen B.
AU  - Larosa, John C.
AU  - Segal, Pesach
AU  - Rifkind, Basil M.
T1  - The Association of Corneal Arcus with Coronary Heart Disease and Cardiovascular Disease Mortality in the Lipid Research Clinics Mortality Follow-up Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/10//
VL  - 80
IS  - 10
M3  - Article
SP  - 1200
EP  - 1204
PB  - American Public Health Association
SN  - 00900036
AB  - The relationship between corneal areus (arcus senilis) and mortality from coronary heart disease (CHD) and cardiovascular disease (CVD) is examined in a prospective study of White men (n) = 3.930) and women non-hormone users (n = 2,139), ages 30-69, followed for an average of 8.4 years as part of the Lipid Research Clinics Mortality Follow-up Study. After excluding those with clinically manifest CHD at baseline, corneal arcus was strongly associated with CHD and CVD mortality only in hyperlipidemic men ages 30-49 years, for whom the relative risk for CHD and CVD death was 3.7 and 4.0, respectively, after adjusting for age, total cholesterol, HDL cholesterol, and smoking status using a Cox proportional hazards model. Among 30-49 year old males, corneal arcus appears to be a prognostic factor for CHD, independent of its association with hyperlipidemia in this age-group, of about the same magnitude as other common risk factors, underscoring the usefulness of corneal arcus as a prognostic factor to the practicing clinician. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARDIOVASCULAR diseases
KW  - MORTALITY
KW  - LIPIDS -- Research
KW  - CLINICS
KW  - WOMEN
KW  - CHOLESTEROL
KW  - SMOKING
KW  - HYPERLIPIDEMIA
N1  - Accession Number: 9101281053; Chambless, Lloyd E. 1 Fuchs, Flavio D. 1 Linn, Shai 2 Kritchevsky, Stephen B. 1 Larosa, John C. 2 Segal, Pesach 2 Rifkind, Basil M. 3; Affiliation:  1: Department of Biostatistics and Epidemiology, University of North Carolina, Chapel Hill  2: Department of Pharmacology, University Federal do Rio Grande do sul , porto Alegre  3: Lipid Metabolism Atherogenesis Branch, National Heart, Lung and Blood Institute, Bethesda, MD.; Source Info: Oct90, Vol. 80 Issue 10, p1200; Subject Term: CARDIOVASCULAR diseases; Subject Term: MORTALITY; Subject Term: LIPIDS -- Research; Subject Term: CLINICS; Subject Term: WOMEN; Subject Term: CHOLESTEROL; Subject Term: SMOKING; Subject Term: HYPERLIPIDEMIA; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schneider, Stanley F.
T1  - Reflections on an Epidemic.
JO  - Journal of Community Psychology
JF  - Journal of Community Psychology
Y1  - 1990/10//
VL  - 18
IS  - 4
M3  - Article
SP  - 310
EP  - 315
PB  - John Wiley & Sons, Inc.
SN  - 00904392
AB  - Several recommendations by a national science advisory body and the intentions of the Public Health Service regarding AIDS are reviewed, and their pertinence to community psychology is noted. The context of these statements is the metamorphosis of the AIDS epidemic and the public's reaction to it. The elements of surprise, continual change, and the need to plan for contingencies are threaded through a presentation of various aspects of the epidemic. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease)
KW  - EPIDEMICS
KW  - PUBLIC health
KW  - COMMUNITY psychology
KW  - EPIDEMIOLOGY
KW  - SOCIAL psychology
N1  - Accession Number: 11977373; Schneider, Stanley F. 1; Affiliation:  1: National Institute of Mental Health.; Source Info: Oct90, Vol. 18 Issue 4, p310; Subject Term: AIDS (Disease); Subject Term: EPIDEMICS; Subject Term: PUBLIC health; Subject Term: COMMUNITY psychology; Subject Term: EPIDEMIOLOGY; Subject Term: SOCIAL psychology; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rappersberger, Klemens
AU  - Tschachler, Erwin
AU  - Zonzits, Eva
AU  - Gillitzer, Reinhard
AU  - Hatzakis, Angelos
AU  - Kaloterakis, Andreas
AU  - Mann, Dean L.
AU  - Popow-Kraupp, Theresa
AU  - Biggar, Robert J.
AU  - Berger, Rudolf
AU  - Stratigos, Joannis
AU  - Wolff, Klaus
AU  - Stingl, Georg
T1  - Endemic Kaposi's Sarcoma in Human Immunodeficiency Virus Type 1--Seronegative Persons: Demonstration of Retrovirus-Like Particles in Cutaneous Lesions.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/10//
VL  - 95
IS  - 4
M3  - Article
SP  - 371
EP  - 381
SN  - 0022202X
AB  - In 1984, Greek physicians reported on the clustering of cases of Kaposi's sarcoma (KS) on the Peloponnesus peninsula. To gain more insight into its pathogenesis, we studied the seroepidemiologic and clinicopathologic characteristics of 12 Greek KS patients (eight male/four female) five of whom were residents of an endemic area on the Peloponnesus. These patients were in good general health with ages ranging from 48 to 80 years, had no clinical signs of immunodeficiency, and combined the features of both classic and epidemic KS in that they displayed not only involvement of acral areas but also widespread mucocutaneous lesions. Routine laboratory data were within normal limits; no patient had HTLV-1 and HIV-½ antibodies, but all patients had antibodies to several herpesviruses. The histopathology was characteristic of KS with the peculiar feature of a dense infiltrate composed predominantly of CD4+ T lymphocytes. Immunoenzymatic/morphologic studies of the KS cells were consistent with their origin from lymphatic endothelium. Outstanding ultrastrucrural findings were tubuloreticular structures and cylindrical confronting cisternae, structures that are indicative of an ongoing viral infection. Indeed, extensive electrommicroscopic studies resulted in the detection of retrovirus-like particles in close association to KS cells in five of 12 patients. This in situ observation opens the possibility that this retro-virus contributes to KS development. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KAPOSI'S sarcoma
KW  - RETROVIRUSES
KW  - HIV (Viruses)
KW  - HERPESVIRUSES
KW  - PELOPONNESUS (Greece : Peninsula)
KW  - GREECE
N1  - Accession Number: 12555450; Rappersberger, Klemens 1 Tschachler, Erwin 1 Zonzits, Eva 1 Gillitzer, Reinhard 1 Hatzakis, Angelos 2 Kaloterakis, Andreas 3 Mann, Dean L. 4 Popow-Kraupp, Theresa 5 Biggar, Robert J. 6 Berger, Rudolf 1 Stratigos, Joannis 7 Wolff, Klaus 1 Stingl, Georg 1; Affiliation:  1: Division of Cutaneous Immunobiology, Department of Dermatology I, University of Vienna Medical School, Vienna, Austria.  2: Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece  3: Department of Internal Medicine, University of Athens Medical School, Athens, Greece  4: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick and Bethesda, Maryland, U.S.A.  5: Institute of Virology, University of Vienna Medical School, Vienna, Austria.  6: Viral Epidemiology Section, National Cancer Institute, Frederick and Bethesda, Maryland, U.S.A.  7: Department of Dermatology, University of Athens Medical School, Athens, Greece; Source Info: Oct90, Vol. 95 Issue 4, p371; Subject Term: KAPOSI'S sarcoma; Subject Term: RETROVIRUSES; Subject Term: HIV (Viruses); Subject Term: HERPESVIRUSES; Subject Term: PELOPONNESUS (Greece : Peninsula); Subject Term: GREECE; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1523-1747.ep12555450
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Finzi, Eric
AU  - Fleming, Timothy
AU  - Pierce, Jacalyn H.
T1  - Retroviral Expression of Transforming Growth Factor-Alpha Does Not Transform Fibroblasts or Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/10//
VL  - 95
IS  - 4
M3  - Article
SP  - 382
EP  - 387
SN  - 0022202X
AB  - Transforming growth factor α (TGFα) is a peptide so named because it helps to impart anchorage-independent growth to normal rat kidney (NRK) cells in vitro and is secreted by many rodent and human tumor cells. To directly investigate the transforming properties of this factor, we constructed a replication-defective murine retrovirus that expresses the human sequence coding for TGFα. infection of NIH/3T3 cells with the TGFα retrovirus led to the integration of a transcriptionally active provirus and overexpression of biologically active TGFα, but failed to induce morphologic transformation. Similarly, the TGFα retrovirus failed to induce morphologic transformation of five other types of rodent fibroblasts. We also investigated the effect of TGFα expression on the growth of BALB/MK mouse keratinocytes, which require epidermal growth factor (EGF) for proliferation. We show that exogenously added TGFα is an extremely potent mitogen for BALB/MK cells. However, retroviral expression of TGFa in BALB/MK cells failed to relieve dependence on exogenously added EGF (or TGFα) for cell growth. These results suggest that overexpression of TGFα does not, by itself, transform rodent fibroblasts or keratinocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSFORMING growth factors
KW  - RETROVIRUSES
KW  - FIBROBLASTS
KW  - EPIDERMAL growth factor
KW  - KERATINOCYTES
KW  - GROWTH factors
N1  - Accession Number: 12555464; Finzi, Eric 1 Fleming, Timothy 1 Pierce, Jacalyn H. 1; Affiliation:  1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland U.S.A.; Source Info: Oct90, Vol. 95 Issue 4, p382; Subject Term: TRANSFORMING growth factors; Subject Term: RETROVIRUSES; Subject Term: FIBROBLASTS; Subject Term: EPIDERMAL growth factor; Subject Term: KERATINOCYTES; Subject Term: GROWTH factors; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12555464
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104752290
T1  - Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia.
AU  - Joris, J
AU  - Costello, A
AU  - Dubner, R
AU  - Hargreaves, K M
Y1  - 1990/10//1990 Oct
N1  - Accession Number: 104752290. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Body Temperature -- Drug Effects
KW  - Edema -- Drug Therapy
KW  - Narcotics -- Pharmacodynamics
KW  - Pain -- Drug Therapy
KW  - Analgesics -- Pharmacodynamics
KW  - Analgesics, Opioid -- Pharmacodynamics
KW  - Animal Studies
KW  - Chemistry
KW  - Dextrorphan -- Pharmacodynamics
KW  - Dose-Response Relationship, Drug
KW  - Edema -- Chemically Induced
KW  - Male
KW  - Morphine -- Pharmacodynamics
KW  - Naltrexone -- Pharmacodynamics
KW  - Narcotics -- Therapeutic Use
KW  - Pain -- Physiopathology
KW  - Polysaccharides
KW  - Rats
SP  - 95
EP  - 103
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 43
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 2277720.
DO  - 10.1016/0304-3959(90)90054-H
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104751605
T1  - Cerebral blood flow in experimental ischemia assessed by 19F magnetic resonance spectroscopy in cats.
AU  - Brunetti, A
AU  - Nagashima, G
AU  - Bizzi, A
AU  - DesPres, D J
AU  - Alger, J R
Y1  - 1990/10//1990 Oct
N1  - Accession Number: 104751605. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Cerebrovascular Circulation
KW  - Cerebral Ischemia, Transient -- Physiopathology
KW  - Animals
KW  - Cats
KW  - Chlorofluorocarbons
KW  - Halogens
KW  - Magnetic Resonance Spectroscopy -- Methods
KW  - Reference Values
SP  - 1439
EP  - 1444
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 21
IS  - 10
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - We evaluated a 19F magnetic resonance spectroscopic technique that detects Freon-23 washout as a means of measuring cerebral blood flow in halothane-anesthetized adult cats during and after transient cerebral ischemia produced by vascular occlusion. The experiments were performed to test the ability of this recently developed method to detect postischemic flow deficits. Results were consistent with postischemic hypoperfusion. The method also proved valuable for measuring small residual flow during vascular occlusion. Our experiments indicate that this method provides simple, rapid, and repeatable flow measurements that can augment magnetic resonance examinations of cerebral metabolic parameters in the study of ischemia.
SN  - 0039-2499
AD  - Neuroimaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 2219209.
DO  - 10.1161/01.STR.21.10.1439
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Smith, Susan J.
AU  - Eisenberg, Evan
T1  - A comparison of the effect of vanadate on the binding of myosin-subfragment-1 • ADP to actin and on actomyosin subfragment 1 ATPase activity.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1990/10/05/
VL  - 193
IS  - 1
M3  - Article
SP  - 69
EP  - 73
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Equilibrium binding studies were used to determine the binding constant of vanadate ion (Vi), to the complex of actomyosin subfragnent 1 (S1) with ADP and Vi and of act to the myosin S1 · ADP · Vi complex. The proteins used were obtained from rabbit skeletal muscle. Pre-steady-state measurements were also performed to determine the rates of VI association and dissociation from the actomyosin S1 · ADP· V1 complex. Using these measured values in a simple model, the steady-state actomyosin S1 ATPase activity was predicted over a range of VI concentrations. This model predicted that Vi would have little effect on the actomyosin SI ATPase activity. In agreement with this prediction, the measured ATPase activity of actomyosin S1 was not greatly inhibited by Vi, except at high concentrations at which polymeric species of Vi may occur ( > 900 µM). [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VANADATES
KW  - ACTOMYOSIN
KW  - MUSCLES
KW  - RABBITS as laboratory animals
KW  - DISSOCIATION (Chemistry)
KW  - ADENOSINE triphosphatase
N1  - Accession Number: 13758264; Smith, Susan J. 1 Eisenberg, Evan 1; Affiliation:  1: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA; Source Info: 10/5/90, Vol. 193 Issue 1, p69; Subject Term: VANADATES; Subject Term: ACTOMYOSIN; Subject Term: MUSCLES; Subject Term: RABBITS as laboratory animals; Subject Term: DISSOCIATION (Chemistry); Subject Term: ADENOSINE triphosphatase; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Lubin, Jay H.
T1  - Quantitative Evaluation of the Radon and Lung Cancer Association in a Case Control Study of Chinese Tin Miners.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1990/10/10/
VL  - 264
IS  - 14
M3  - Abstract
SP  - 1862
EP  - 1862
SN  - 00987484
AB  - Presents an abstract of the study titled 'Quantitative Evaluation of the Radon and Lung Cancer Association in a Case Control Study of Chinese Tin Miners.'
KW  - RADON
KW  - LUNGS -- Cancer
KW  - TIN miners
KW  - CHINA
N1  - Accession Number: 10978700; Lubin, Jay H. 1; Affiliation:  1: Epidemiologic Methods Section, Biostatics Branch, National Cancer Institute; Source Info: 10/10/90, Vol. 264 Issue 14, p1862; Subject Term: RADON; Subject Term: LUNGS -- Cancer; Subject Term: TIN miners; Subject Term: CHINA; Number of Pages: 1/3p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Subar, Amy F.
AU  - Harlan, Linda C.
AU  - Mattson, Margaret E.
T1  - Food and Nutrient Intake Differences Between Smokers and Non-Smokers in the US.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/11//
VL  - 80
IS  - 11
M3  - Article
SP  - 1323
EP  - 1329
PB  - American Public Health Association
SN  - 00900036
AB  - Data from the Second National Health and Nutrition Examination survey were analyzed to determine food and nutrient intake differences between current smokers (also categorized as light, moderate, and heavy smokers) and non-smokers. Smokers in several age-race-sex categories have lower intake of vitamin C, folate, fiber and vitamin A than non-smokers, and intake tended to decrease as cigarette consumption increased, particularly for vitamin C, fiber, and folate. Smokers were less likely to have consumed vegetables, fruits (particularly fruits and vegetables high in vitamins C and A) high fiber grains, low fat milk, and vitamin and mineral supplements than non-smokers. A negative linear trend was found between smoking intensity and intake of several categories of fruits and vegetables. These data suggest that the high cancer risk associated with smoking is compounded by somewhat lower intake of nutrients and foods which are thought to be cancer protective. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PUBLIC health
KW  - NUTRITION
KW  - CIGARETTE smokers
KW  - SMOKING
KW  - FOOD habits
KW  - VITAMINS
KW  - VEGETABLES
KW  - FRUIT
KW  - FIBER in human nutrition
N1  - Accession Number: 9012241084; Subar, Amy F. 1 Harlan, Linda C. 1 Mattson, Margaret E. 1; Affiliation:  1: National  Cancer Institute, Division of Cancer Prevention and Control, National Institutes of Health; Source Info: Nov90, Vol. 80 Issue 11, p1323; Subject Term: PUBLIC health; Subject Term: NUTRITION; Subject Term: CIGARETTE smokers; Subject Term: SMOKING; Subject Term: FOOD habits; Subject Term: VITAMINS; Subject Term: VEGETABLES; Subject Term: FRUIT; Subject Term: FIBER in human nutrition; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pinsky, Joan L.
AU  - Jette, Alan M.
AU  - Branch, Laurence G.
AU  - Kannel, William B.
AU  - Feinleib, Manning
T1  - The Framingham disability study: Relationship of various coronary heart disease manifestations to Disability in Older Persons Living in the Community.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/11//
VL  - 80
IS  - 11
M3  - Article
SP  - 1363
EP  - 1367
PB  - American Public Health Association
SN  - 00900036
AB  - The relation between coronary heart disease and disability was examined in 2,576 community-dwelling women and men ages 55-88 years. These Framingham Study participants were originally recruited in 1948-51 for an examination of cardiovascular disease. Twenty-seven years later, remaining members of the cohort were interviewed to ascertain physical abilities, and a score on a disability scale was assigned. Multivariate logistic analyses examined disability in relation to uncomplicated angina pectoris (AP), complicated AP, and coronary heart disease other than AP, controlling for possible confounders. In younger and older women and men, uncomplicated und complicated AP were associated with disability. Coronary heart disease other than AP was associated with disability only in the younger men. Congestive heart failure predicted disability only in the women. These results suggest that onset of AP should be recognized as a critical point in the development of disability and that AP is a better predictor of disability than is myocardial infarction of coronary insufficiency. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORONARY heart disease
KW  - WOMEN -- Diseases
KW  - MEN -- Diseases
KW  - HEART diseases in women
KW  - CARDIOLOGY
KW  - INTERNAL medicine
KW  - HEART failure
KW  - CARDIAC arrest
KW  - MYOCARDIAL infarction
N1  - Accession Number: 9012241092; Pinsky, Joan L. 1 Jette, Alan M. 2 Branch, Laurence G. 3 Kannel, William B. 4 Feinleib, Manning 5; Affiliation:  1: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Federal Building, Rm 2C08, Bethesda, MD 20892  2: . Dr. Jette is with the Institute of Health Professions, Massachusetts  General Hospital, Boston  3: Gerontology Center, Boston University  4: Department of Medicine, Boston University School of Medicine, Section of Preventive Medicine and Epidemiology  5: Director ofthe National Center for Health Statistics; Source Info: Nov90, Vol. 80 Issue 11, p1363; Subject Term: CORONARY heart disease; Subject Term: WOMEN -- Diseases; Subject Term: MEN -- Diseases; Subject Term: HEART diseases in women; Subject Term: CARDIOLOGY; Subject Term: INTERNAL medicine; Subject Term: HEART failure; Subject Term: CARDIAC arrest; Subject Term: MYOCARDIAL infarction; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jetten, Anton M.
T1  - Multi-Stage Program of Differentiation in Human Epidermal Keratinocytes: Regulation by Retinoids.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/11//
VL  - 95
IS  - 5
M3  - Article
SP  - 44S
EP  - 46S
SN  - 0022202X
AB  - The proliferation and differentiation of epidermal keratinocytes in vivo and in vitro is influenced by a variety of different factors, including several peptide growth factors, protein kinase C activators, retinoids, and various cytokines. Retinoids can affect the proliferation of human epidermal keratinocytes either positively or negatively and influence the multi-step program of differentiation in epidermal keratinocytes at very specific stages. Epidermal keratinocytes express nuclear retinoic acid receptors, RARα, and RARγ. It is likely that at least some of the alterations in gene expression induced by retinoids are mediated through these RAR. The cytosolic retinoic acid-binding protein (CRABP), which is differentially expressed during squamous differentiation of human epidermal keratinocytes, may control the effective concentration of retinoic acid in the cell and therefore regulate indirectly gene expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - RETINOIDS
KW  - CYTOKINES
KW  - PROTEIN kinase C
KW  - TRETINOIN
KW  - GENE expression
N1  - Accession Number: 12505757; Jetten, Anton M. 1; Affiliation:  1: Cell Bioiogy Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, North Carolina, U.S.A.; Source Info: Nov90, Vol. 95 Issue 5, p44S; Subject Term: KERATINOCYTES; Subject Term: RETINOIDS; Subject Term: CYTOKINES; Subject Term: PROTEIN kinase C; Subject Term: TRETINOIN; Subject Term: GENE expression; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12505757
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12505757&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenthal, Dean S.
AU  - Roop, Dennis R.
AU  - Huff, Carol A.
AU  - Weiss, Jonathan S.
AU  - Ellis, Charles N.
AU  - Hamilton, Ted
AU  - Voorhees, John J.
AU  - Yuspa, Stuart H.
T1  - Changes in Photo-Aged Human Skin Following Topical Application of All-Trans Retinoic Acid.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/11//
VL  - 95
IS  - 5
M3  - Article
SP  - 510
EP  - 515
SN  - 0022202X
AB  - Although topical applications of retinoids on rodents and humans have been shown to cause epidermal hyperplasia, a detailed study of the influence of retinoids on epidermal differentiation in vivo has not been performed. In order to assess the pharmacologic effects of chronic topical tretinoin application used to improve the appearance of patients with photoaged skin, cutaneous biopsies from 25 patients in a controlled clinical study were examined histologically and immunocytochemically. Chronic application of tretinoin causes epidermal thickening (25 of 25 samples), stratum granulosum thickening (15 of 25), parakeratosis (13 of 25), a marked increase in the number of cell layers expressing epidermal transglutaminase (13 of 25), and focal expression of two keratins, K6 (12 of 25) and K13 (8 of 25), not normally expressed in the epidermis. The morphologic changes correlated with immunohistochemical abnormalities; neither of these correlated with the subjective cosmetic response. Three major epidermal differentiation products, keratins K1, K10, and K14 were not altered, within the limits of the methods used. Thus, chronic topical tretinoin reprograms some, but not all, aspects of human epidermal differentiation in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - TRETINOIN
KW  - HYPERPLASIA
KW  - RETINOIDS
KW  - IMMUNOLOGY
KW  - PHARMACOLOGY
N1  - Accession Number: 12504718; Rosenthal, Dean S. 1 Roop, Dennis R. 2 Huff, Carol A. 1 Weiss, Jonathan S. 3 Ellis, Charles N. 4 Hamilton, Ted 4 Voorhees, John J. 4 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland.  2: Departments of Cell Biology and Dermatology, Baylor College of Medicine, Houston, Texas.  3: Emory Clinic, Atlanta, Georgia.  4: Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.; Source Info: Nov90, Vol. 95 Issue 5, p510; Subject Term: SKIN; Subject Term: TRETINOIN; Subject Term: HYPERPLASIA; Subject Term: RETINOIDS; Subject Term: IMMUNOLOGY; Subject Term: PHARMACOLOGY; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12504718
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Judd, Lewis L.
T1  - What Must Be Done to Ensure the NATION'S MENTAL HEALTH.
JO  - USA Today Magazine
JF  - USA Today Magazine
Y1  - 1990/11//
VL  - 119
IS  - 2546
M3  - Article
SP  - 73
EP  - 75
SN  - 01617389
AB  - Looks on strategies to improve the public's mental health in the United States.  Medical care of individuals suffering from mental disorders; Health maintenance organizations' tendency to discriminate the mentally ill; National prevention and education programs to inform people of mental disorders; Role of the National Institute of Mental Health in improving mental health.
KW  - MENTAL health
KW  - PUBLIC health
KW  - MENTAL illness -- Treatment
KW  - UNITED States
N1  - Accession Number: 11758723; Judd, Lewis L. 1; Affiliation:  1: National Institute of Mental Health, Bethesda, Md.; Source Info: Nov90, Vol. 119 Issue 2546, p73; Subject Term: MENTAL health; Subject Term: PUBLIC health; Subject Term: MENTAL illness -- Treatment; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 3 Black and White Photographs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06453-023
AN  - 2006-06453-023
AU  - Abeles, Ronald P.
T1  - Control and Aging.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1990/11//
VL  - 35
IS  - 11
SP  - 1067
EP  - 1068
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06453-023. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Abeles, Ronald P.; National Institute on Aging, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Aging; Gerontology; Helplessness; Personality. Classification: Gerontology (2860). Population: Human (10). Reviewed Item: Fry, Prem S. (Ed). Psychological Perspectives of Helplessness and Control in the Elderly=Amsterdam: North-Holland, 1989. 442 pp. $112.25 (Dfl. 230.00); 1989. References Available: Y. Page Count: 2. Issue Publication Date: Nov, 1990. 
AB  - Reviews the book, Psychological Perspectives of Helplessness and Control in the Elderly edited by Prem S. Fry (see record [rid]1989-97131-000[/rid]). With aging, forces within and without the person are postulated as leading to diminished control. The physical changes accompanying old age and the internalization of negative age-stereotypes are believed to attack the older person's self-concept and self-efficacy expectations. Although almost all of the contributors to this volume assume that control has beneficial consequences, the darker side of control is also recognized. Indeed, as Fry notes, 'in contradistinction to the idea that the need to control is permanent and unchanging in old age, it has been suggested that the conscious desire for control is not a penultimate articulation of most older persons' personality'. In sum, this volume deals with many central issues in the psychology of control and in the psychology of aging and, as such, makes an excellent companion to Margret and Paul Bakes' The Psychology of Control and Aging. Although there is some overlap in the contributors and subject matter of these two volumes, they are sufficiently different to warrant reading both. These books are not written as introductions to the psychology of control or the psychology of aging. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychological perspectives
KW  - helplessness
KW  - elderly
KW  - aging
KW  - personality
KW  - 1990
KW  - Aging
KW  - Gerontology
KW  - Helplessness
KW  - Personality
KW  - 1990
U2  - Fry, Prem S. (Ed). (1989); Psychological Perspectives of Helplessness and Control in the Elderly; Amsterdam: North-Holland, 1989. 442 pp. $112.25 (Dfl. 230.00); 0-444-70546-5.
DO  - 10.1037/030583
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06453-033
AN  - 2006-06453-033
AU  - Costa, Paul T. Jr.
AU  - Stone, Stephanie V.
T1  - Understanding Brain-Behavior Links in Aging.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1990/11//
VL  - 35
IS  - 11
SP  - 1080
EP  - 1081
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06453-033. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Costa, Paul T. Jr.; Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Brain; Cognition; Intelligence; Neuropsychology. Minor Descriptor: Cognitive Ability; Disorders; Mental Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Reviewed Item: Albert, Marilyn S. (Ed); Moss, Mark B. (Ed). Geriatric Neuropsychology=New York: Guilford Press, 1988. 316 pp. $32.50; 1988. Page Count: 2. Issue Publication Date: Nov, 1990. 
AB  - Reviews the book, Geriatric Neuropsychology edited by Marilyn S. Albert and Mark B. Moss (see record [rid]1988-98391-000[/rid]). The book is divided into five sections. The first is devoted to an introduction to general issues in aging research. The second section treats normal age changes in intelligence and cognition measures in two separate chapters. The third and largest section devotes six chapters to cognitive deficits, assorted psychiatric symptoms, acute confusional states, depression and other psychiatric disorders, and cerebrovascular disorders. Section IV contains three excellent chapters on neuroimaging via CT, PET, and EEG/EP. In the final chapter, 'Future Directions in the Study of Aging,' Moss and Albert suggest that 'successful aging' is more than the obverse of age-related decline and that more attention should be paid to cognitive remediation, biomarkers of aging, and development of adequate animal models of aging. On the other hand, there is somewhat less emphasis on neuropsychological assessment than the title implies, and there is some unevenness in the level of prior knowledge required by the various chapters. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain-behavior
KW  - geriatric neuropsychology
KW  - aging
KW  - cognition
KW  - intelligence
KW  - 1990
KW  - Brain
KW  - Cognition
KW  - Intelligence
KW  - Neuropsychology
KW  - Cognitive Ability
KW  - Disorders
KW  - Mental Disorders
KW  - 1990
U2  - Albert, Marilyn S. (Ed); Moss, Mark B. (Ed). (1988); Geriatric Neuropsychology; New York: Guilford Press, 1988. 316 pp. $32.50; 0-89862-722-2.
DO  - 10.1037/030593
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 104750933
T1  - 70-kDa heat shock protein and c-fos gene expression after transient ischemia.
AU  - Nowak Jr, T S
AU  - Ikeda, J
AU  - Nakajima, T
AU  - Nowak, T S Jr
Y1  - 1990/11/02/1990 Nov Suppl
N1  - Accession Number: 104750933. Language: English. Entry Date: 20110610. Revision Date: 20161125. Publication Type: journal article. Supplement Title: 1990 Nov Suppl. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Gene Expression
KW  - Proteins
KW  - Cerebral Ischemia, Transient
KW  - RNA -- Analysis
KW  - Animals
KW  - Female
KW  - Rodents
KW  - Hippocampus
KW  - Cerebral Ischemia, Transient -- Metabolism
SP  - III107
EP  - 11
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 21
IS  - 11
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Induction of messenger RNA encoding the 70-kDa heat shock or stress protein, hsp70, and the product of the proto-oncogene c-fos was evaluated in gerbil hippocampus by in situ hybridization at various recirculation intervals after 5 minutes of ischemia. Striking increases in c-fos RNA were observed in dentate granule cells within 15 minutes of recirculation and remained evident through 1 hour, returning to undetectable control levels by 3 hours. Modest c-fos hybridization was seen in CA1 and CA3 neurons during the same time course. These results are consistent with the rapid and transient stimulation-induced c-fos expression observed in many experimental systems. Hsp70 expression showed a longer time course, being strongly induced in all major hippocampal neuron populations within 3 hours and persisting for approximately 12 hours in dentate granule cells and through 24 hours in CA3 pyramidal neurons. Notably, the most prolonged expression of hsp70 RNA was observed in vulnerable CA1 neurons that minimally accumulate the immunoreactive protein, with hybridization detected essentially until the death of this cell population at 3-4 days. These studies demonstrate an overlapping distribution of hsp70 and c-fos expression in gerbil hippocampus after ischemia, although there are differences in time course and in the relative induction observed in different neuron populations. The transient increase in c-fos hybridization in dentate granule cells is identical to that seen in various seizure paradigms and provides further support for activation of hippocampal circuitry after ischemia. The prolonged time course of hsp70 messenger RNA expression in vulnerable CA1 neurons may provide a molecular correlate of proposed excitotoxic mechanisms mediating delayed neuronal death.
SN  - 0039-2499
AD  - Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892
AD  - Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
U2  - PMID: 2122554.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104751785
T1  - Effects of MK-801 on recovery from sensorimotor cortex lesions.
AU  - Barth, T M
AU  - Grant, M L
AU  - Schallert, T
Y1  - 1990/11/02/1990 Nov Suppl
N1  - Accession Number: 104751785. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Supplement Title: 1990 Nov Suppl. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Brain Diseases -- Physiopathology
KW  - Hydrocarbons -- Therapeutic Use
KW  - Nervous System -- Physiopathology
KW  - Parietal Lobe -- Physiopathology
KW  - Animals
KW  - Brain Diseases -- Drug Therapy
KW  - Hydrocarbons -- Pharmacodynamics
KW  - Male
KW  - Movement
KW  - Nervous System -- Drug Effects
KW  - Neural Pathways -- Physiology
KW  - Physical Stimulation
KW  - Rats
KW  - Parietal Lobe -- Drug Effects
SP  - III153
EP  - 7
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 21
IS  - 11
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Histologic evidence suggests that drugs acting as noncompetitive antagonists at the N-methyl-D-aspartate receptor can have beneficial or pathologic effects on central nervous system neurons. In the present experiments we examined the effects of MK-801 on recovery of behavioral function after unilateral lesions in the rat somatic sensorimotor cortex. In the first experiment, rats with unilateral sensorimotor cortex lesions were given either MK-801 (1 mg/kg) or saline 12-16 hours after surgery. Additional injections were given on postoperative days 2, 4, and 6. Behavioral tests measured somatosensory asymmetries (i.e., bilateral tactile stimulation tests) and forelimb placing. After creation of sensorimotor cortex lesions, rats showed an ipsilateral somatosensory bias and an impairment in placing the contralateral forelimb. Rats treated with MK-801 recovered slightly faster than saline-treated animals as measured by a bilateral tactile stimulation test (p less than 0.05). In contrast, there was no significant difference between the groups in the recovery of forelimb placing. In a second experiment, rats with sensorimotor cortex lesions were treated with a single injection of MK-801 after behavioral recovery. Twenty hours after the MK-801 injection, rats with sensorimotor cortex lesions showed a reinstatement of the placing deficits. The impairment endured for at least 7 days after injection. These behavioral data support the idea that MK-801 can have either beneficial or detrimental effects when administered after brain damage.
SN  - 0039-2499
AD  - Laboratory of Neurophysiology, National Institute of Mental Health, National Institutes of Health Animal Center, Poolsville, Md.
U2  - PMID: 2237974.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104751796
T1  - Putative neuroexcitation in cerebral ischemia and brain injury.
AU  - Ikeda, J
AU  - Nagashima, G
AU  - Saito, N
AU  - Nowak Jr, T S
AU  - Joo, F
AU  - Mies, G
AU  - Lohr, J M
AU  - Ruetzler, C A
AU  - Klatzo, I
AU  - Nowak, T S Jr
Y1  - 1990/11/02/1990 Nov Suppl
N1  - Accession Number: 104751796. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Supplement Title: 1990 Nov Suppl. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Brain Injuries -- Pathology
KW  - Cerebral Ischemia -- Pathology
KW  - Animals
KW  - Brain Injuries -- Metabolism
KW  - Cerebral Ischemia -- Metabolism
KW  - Calcium -- Metabolism
KW  - Rodents
KW  - Hippocampus -- Metabolism
KW  - Hippocampus -- Pathology
KW  - Neurons -- Pathology
KW  - Rats
KW  - Thalamus -- Metabolism
KW  - Thalamus -- Pathology
SP  - III65
EP  - 70
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 21
IS  - 11
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Involvement of neuroexcitatory mechanisms in cerebral ischemia and brain injury was explored in experimental models of repetitive forebrain ischemia by temporary occlusion of carotid arteries in gerbils and cryogenic injury to the cerebral cortex in rats and gerbils. Our observations in these models revealed a pattern of injury that involved some anatomic structures outside the areas of direct ischemic or traumatic insult. Such foci of injury revealed conspicuously abnormal uptake of 45Ca associated with slight or moderate neuronal alteration, whereas severely injured areas showed no 45Ca uptake. Electron microscopic observations revealed a characteristic presence of calcium in swollen dendrites, closely resembling pictures obtained in neuroexcitatory conditions such as epileptic seizures. Abnormal uptake of 45Ca was associated with apparent blood-brain barrier changes characterized by intracytoplasmic uptake of extravasated albumin into the neurons. Protein synthesis assayed by in vivo [3H]leucine incorporation was reduced in regions showing calcium accumulation. Our observations suggest that neuroexcitation may play an important role in development of secondary and chronic changes after ischemic or traumatic brain insults.
SN  - 0039-2499
AD  - Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md 20892.
U2  - PMID: 2237987.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Polis, Michael A.
AU  - Masur, Henry
T1  - Predicting the Progression to AIDS.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1990/12//
VL  - 89
IS  - 6
M3  - Editorial
SP  - 701
EP  - 705
SN  - 00029343
AB  - This article discusses the progression of HIV infection to the development of AIDS. For an individual infected with HIV, the period between acquisition of HIV infection and symptomatic disease is extremely variable, as is the rate of immunologic decline. Several cohort studies, as of December 1990, with data from the time of infection to the development of AIDS have determined that the median time from HIV seroconversion to the development of AIDS is 7 to 11 years. Only about 5% of the persons in these cohorts developed AIDS within the first 3 years after infection with HIV. Over the next 8 years, AIDS developed in approximately 3% to 7% of persons per year. Using mathematical modeling to extrapolate data trends, estimates for the percent of persons who will develop AIDS following the acquisition of HIV infection range from 65% to 100% at 16 years. The importance of the CD4 T lymphocyte as a target of HIV, as a marker for progressive immunologic deteriorations and as a predictor of the development of AIDS in the HIV-infected person has become increasingly clear. Knowledge of CD4 counts or percentages have enabled health care providers to target prophylaxis to subsets of HIV-infected persons for whom the benefits of prevention clearly outweigh the toxicities.
KW  - AIDS (Disease)
KW  - HIV-positive persons
KW  - PROGNOSIS
KW  - HIV infections
KW  - COMMUNICABLE diseases
N1  - Accession Number: 9101213214; Polis, Michael A. 1 Masur, Henry 1; Affiliation:  1: Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland; Source Info: Dec90, Vol. 89 Issue 6, p701; Subject Term: AIDS (Disease); Subject Term: HIV-positive persons; Subject Term: PROGNOSIS; Subject Term: HIV infections; Subject Term: COMMUNICABLE diseases; Number of Pages: 5p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Patterson, Blossom H.
AU  - Block, Gladys
AU  - Rosenberger, William F.
AU  - Pee, David
AU  - Kahle, Lisa L.
T1  - Fruit and Vegetables in the American Diet: Data From the NHANES II Survey.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/12//
VL  - 80
IS  - 12
M3  - Article
SP  - 1443
EP  - 1449
PB  - American Public Health Association
SN  - 00900036
AB  - Twenty-four hour dietary recall data from the Second National Health and Nutrition Examination Survey (1976-80) were used to estimate the numbers of servings of fruit and vegetables consumed by Black and White adults, to examine the types of servings (e.g., potatoes, garden vegetables, fruit, and juice), and to estimate the mean intake of calories, fat, dietary fiber, and vitamins A and C by number of servings. An estimated 45 percent of the population had no servings of fruit or juice and 22 percent had no servings of a vegetable on the recall day. Only 27 percent consumed the three or more servings of vegetable and 29 percent had the two or more servings of fruit recommended by the US Departments of Agriculture and of Health and Human Services; 9 percent bad both Consumption was lower among Blacks than Whites. The choice of vegetables lacked variety. Diets including at least three servings of vegetables and two servings of fruit contained about 17 grams at dietary fiber. Although caloric and fat intake increased with increasing servings of fruit and vegetables, the percent of calories from remained relatively constant. Although these data are 10 years old, more recent surveys have shown similar results. The discrepancy between dietary guidelines and the actual diet suggests a need for extensive public education. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FRUIT
KW  - VEGETABLES
KW  - FOOD crops
KW  - NUTRITION
KW  - DIET
KW  - PUBLIC health
KW  - VITAMIN A
KW  - CAROTENES
KW  - VITAMIN C
N1  - Accession Number: 9012241107; Patterson, Blossom H. 1 Block, Gladys 2 Rosenberger, William F. 3 Pee, David 3 Kahle, Lisa L. 3; Affiliation:  1: Clinical and Diagnostic Trials Section, Biometry branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Rm 344, Bethesda, MD 20892  2: Section, NCI.  3: Information Management Services, Inc., Silver Spring, MD; Source Info: Dec1990, Vol. 80 Issue 12, p1443; Subject Term: FRUIT; Subject Term: VEGETABLES; Subject Term: FOOD crops; Subject Term: NUTRITION; Subject Term: DIET; Subject Term: PUBLIC health; Subject Term: VITAMIN A; Subject Term: CAROTENES; Subject Term: VITAMIN C; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Solomon, Rachel E.
AU  - VanRaden, Mark
AU  - Kaslow, Richard A.
AU  - Lyter, David
AU  - Visscher, Barbara
AU  - Farzadegan, Homayon
AU  - Phair, John
T1  - Association of hepatitis B surface antigen and core antibody with acquisition and manifestations of Hunan Immunodeficiency Virus Type 1 (HIV-1) Infection.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/12//
VL  - 80
IS  - 12
M3  - Article
SP  - 1475
EP  - 1468
PB  - American Public Health Association
SN  - 00900036
AB  - We examined the associations between seropositivity for hepatitis B virus (HBV) with the presence or development of antibodies to human immunodeficiency virus (HIV-l) and with HIV-1 induced T-helper lymphocyte deficiency or acquired immunodeficiency syndrome (AIDS). Serologic data on HBV and HIV-1, cytometric enumeration of CD4+ lymphocytes, clinical events (AIDS by Centers for Disease Control criteria) and hepatitis B Vaccination histories were available on 4,498 homosexual participants in the Mulitcenter AIDS Cohort Study. Men were classified as to previous infection with HBV and prevalent or incident infection with HIV-1. Although there was an association between seropositivity for HBV infection and HIV-1 infection at enrollment (odds ratios anti-HBc 2:6; HBs Ag 4.2), the relation between HBV seropositivity and subsequent seroconversion to HIV- 1 was weaker (odds ratios 1.3 and 1.6). HIV-1 seroconversion was also associated with a history of certain other sexually transmitted diseases, but predisposing sexual practices did not account for the association between HBV and HIV-1 infection. Seropositivity for HBV infection at entry was not related to initially low or more rapid subsequent decline in T-helper lymphocyte counts and was not associated with an increased incidence of AIDS during 2.5 years of follow-up. History of vaccination against HBV did not appear to decrease susceptibility to HBV-1 infection or to subsequent progression of immunodeficiency. We conclude that prior HBV infection is unlikely to be specifically associated with acquisition of HIV-1 infection and is unrelated to be more rapid progression of HBV-1-induced immunodeficiency. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEPATITIS
KW  - COMMUNICABLE diseases
KW  - INFLAMMATION
KW  - LIVER diseases
KW  - HEPATITIS B
KW  - ANTIGENS
KW  - HIV (Viruses)
KW  - INFECTION
KW  - DISEASES
N1  - Accession Number: 9012241114; Solomon, Rachel E. 1 VanRaden, Mark 1 Kaslow, Richard A. 1 Lyter, David 2 Visscher, Barbara 3 Farzadegan, Homayon 4 Phair, John 5; Affiliation:  1: National Institute of Allergy and Infectious Diseases, University of Pittsburgh Graduate School of Public Health  2: University of Pittsburgh Graduate School of Public Health  3: UCLA Department of Epidemiology  4: Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health  5: Howard Brown Memorial Clinic/Northwestern University Medical School, Department of Medicine; Source Info: Dec1990, Vol. 80 Issue 12, p1475; Subject Term: HEPATITIS; Subject Term: COMMUNICABLE diseases; Subject Term: INFLAMMATION; Subject Term: LIVER diseases; Subject Term: HEPATITIS B; Subject Term: ANTIGENS; Subject Term: HIV (Viruses); Subject Term: INFECTION; Subject Term: DISEASES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Gridley, Gloria
AU  - McLaughlin, Joseph K.
AU  - Blot, William J.
T1  - Dietary Vitamin C Intake and Cigarette Smoking.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1990/12//
VL  - 80
IS  - 12
M3  - Letter
SP  - 1526
EP  - 1526
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "Dietary Vitamin C Intake and Cigarette Smoking," that was published in the previous issue of "American Journal of Public Health."
KW  - LETTERS to the editor
KW  - VITAMIN C
N1  - Accession Number: 20671816; Gridley, Gloria 1 McLaughlin, Joseph K. 1 Blot, William J. 1; Affiliation:  1: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Rockville, MD 20892; Source Info: Dec1990, Vol. 80 Issue 12, p1526; Subject Term: LETTERS to the editor; Subject Term: VITAMIN C; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 4/5p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mazurek, C.;
AU  - Kennedy, P.;
AU  - Gallelli, J.;
AU  - Goldspiel, B.;
T1  - Compatibility of suramin and hydrocortisone sodium succinate in solution
CT  - Compatibility of suramin and hydrocortisone sodium succinate in solution
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1990/12/01/
VL  - 25
IS  - Dec
SP  - P
EP  - E
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 28-00725; Language: English; Chemical Name: Suramin--145-63-1 Hydrocortisone sodium succinate--125-04-2; Publication Type: Abstract of Meeting Presentation; Section Heading: Drug Stability
N2  - Suramin is a polysulfonated naphthylurea developed in 1915 and initially used in the treatment of human trypanosomiasis. Recently, suramin has been used investigationally in combination with hydrocortisone sodium succinate in the treatment of metastatic cancer with both drugs being administered through separate venous sites. A chemical and physical compatibility study was designed to determine if both drugs could be placed in the same container and infused through one line. Triplicate samples of suramin and hydrocortisone sodium succinate in D5W at concentrations of 0.3 mg/mL and 0.75 mg/mL and 1.5 mg/mL, and 12 mg/mL and 30 mg/mL respectively, in polyolefin containers were assayed using stability indicating HPLC analyses. Samples were drawn at 0, 6, 12, 24 and 48 hours at room and refrigeration temperatures and inspected visually for precipitation, turbidity and color change at each time point. The initial and final pH were recorded with no change in the pH noted during the study. For the respective concentrations given above no apparent chemical or physical instability was noted over 48 hours at room temperature or refrigeration. However, hydrocortisone sodium succinate was found to be more stable at refrigeration than at room temperature for storage conditions greater than 12 hours.
KW  - Suramin--incompatibilities-;
KW  - Hydrocortisone sodium succinate--incompatibilities-;
KW  - Practice Interest Areas--Intravenous Therapy/Infusion Devices--meeting presentations;
KW  - ASHP meeting abstracts--hydrocortisone and suramin incompatibilities;
KW  - Stability--suramin--incompatibilities, hydrocortisone;
KW  - Stability--hydrocortisone sodium succinate--incompatibilities, hydrocortisone;
KW  - Injections--suramin--incompatibilities, hydrocortisone, stability;
KW  - Injections--hydrocortisone sodium succinate--incompatibilities, suramin, stability;
KW  - Storage--suramin--incompatibilities, hydrocortisone, stability;
KW  - Storage--hydrocortisone sodium succinate--incompatibilities, suramin, stability;
KW  - Incompatibilities--suramin and hydrocortisone sodium succinate--stability;
KW  - Incompatibilities--hydrocortisone sodium succinate and suramin--stability;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Lam, N. P.;
AU  - Estep-Riley, S. G.;
AU  - Gallelli, J. F.;
T1  - Cost-effective, statistically valid sterility monitoring program for a pharmacy intravenous admixture service
CT  - Cost-effective, statistically valid sterility monitoring program for a pharmacy intravenous admixture service
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1990/12/01/
VL  - 25
IS  - Dec
SP  - P
EP  - D
AD  - Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 28-00301; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Technology; Institutional Pharmacy PracticeMicrobiology
N2  - The objective of the study was to evaluate the possibilities of extending our current expiration dating policy. This was done by examining the policies of other leading institutions and home care agencies, and assessing our aseptic techniques in preparing intravenous admixtures. The overall goal was to develop a cost-effective, statistically sound sterility monitoring program allowing for extended expiration dating. Selected hospitals and home care agencies were phone surveyed regarding their policies on expiration dating for intravenous admixtures and their quality assurance programs for monitoring sterility. A pilot sterility study was also conducted on hyperalimentation solutions using a commercially available quality control tester to assess the aseptic techniques of our technicians and to establish a baseline. The results of the survey showed that most sterility testing programs implemented at the hospitals or home care agencies have no statistical validity, and there is a lack of standard methods of quality control to insure sterility of intravenous admixtures. The results of the sterility testing demonstrated that our technicians had good aseptic techniques. Based on the results of the survey and the sterility study, an intravenous admixture end-product sterility testing program using cumulative sum control methodology was established. Every hospital pharmacy and home care agency should continuously monitor the sterility of their intravenous admixtures in order to validate their extended expiration dating policy.
KW  - Practice Interest Areas--Intravenous Therapy/Infusion Devices--meeting presentations;
KW  - ASHP meeting abstracts--injections sterility monitoring;
KW  - Costs--tests--sterility, injections;
KW  - Injections--contamination--monitoring, programs;
KW  - Expiration dates--policies and procedures--injections, sterility monitoring;
KW  - Pharmacy, institutional, hospital--quality assurance--injections sterility monitoring;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Minor, J. R.;
T1  - Management of fungal infections in patients with AIDS
CT  - Management of fungal infections in patients with AIDS
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1990/12/01/
VL  - 25
IS  - Dec
SP  - PI
EP  - 21
AD  - Clinical Center, Pharmacy Department, National Institutes of Health, Bethesda, Maryland 20892, USA
N1  - Accession Number: 28-00783; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
KW  - ASHP meeting abstracts--acquired immunodeficiency syndrome;
KW  - Antifungals--prophylaxis--AIDS patients;
KW  - Infections--prophylaxis--AIDS patients;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Adams, J. D.;
AU  - Fallavollita, A.;
AU  - Fortner, C. L.;
T1  - Working with the NCI drug management and authorization section, and obtaining NCI-sponsored investigational drugs for non-research use
CT  - Working with the NCI drug management and authorization section, and obtaining NCI-sponsored investigational drugs for non-research use
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1990/12/01/
VL  - 25
IS  - Dec
SP  - SPG
EP  - -21
AD  - Drug Management and Authorization Section, Division of Cancer Treatment, National Cancer Institute, EPN, Rm 707, Bethesda, MD 20892, USA
N1  - Accession Number: 28-00888; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations; Investigational Drugs
N2  - One of the National Cancer Institute's (NCI) major role is the development and evaluation of new antineoplastic agents, through drug screening and clinical trials. The Drug Management and Authorization Section (DMAS) is primarily responsible for the authorization and management of investigational agents used in NCI sponsored clinical trials. The DMAS is also the primary contact between the oncology community and the NCI to obtain investigational drugs for treatment use and for drug information. The DMAS monitors investigational drug distribution in each of the following steps: (1) initiation of the clinical request, (2) receipt of the clinical drug request, (3) verification of the request, (4) drug allocation, (5) clinical inventory management, (6) follow-up mailings to investigators, (7) compilation of distribution statistics, and (8) monitoring of drug supply and quality. The potential benefit of an investigational drug for the treatment of patients with severe or life-threatening disease often becomes evident long before sufficient data is collected to fulfill the requirements for filing a New Drug Application (NDA) with the Food and Drug Administration (FDA). The NCI, in agreement with the FDA, has developed two mechanisms to make such drugs available to physicians for non-research treatment use in an individual patient, providing, (1) the patient cannot be referred to an ongoing clinical trial, (2) standard therapies have been exhausted and (3) there is objective evidence that the investigational drug being requested is active in the disease for which it is being requested. These are the Group C and Special Exception protocols. In the mid-1970's the Group C program was developed as a system to make investigational drugs which have demonstrated reproducible evidence of efficacy in a tumor type, available to physicians for treatment use in patients with relapsed or refractory disease. Group C drugs are provided to qualified investigators for use in accordance with the protocol provided with the specific agent. The Special Exception mechanism was developed to make investigational drugs available at an earlier stage of development, as compared to Group C drugs, when the data supporting efficacy and safety may be less well established. A properly trained clinician can request to use any NCI-sponsored investigational drug for treatment use. Each request is handled individually and approved or denied based on the patients medical history and currently available research data. The presentation will discuss the role of the DMAS in supporting the NCI investigational drug development program and how clinicians can obtain NCI-sponsored investigational drug for treatment use through the Group C and Special Exception mechanisms.
KW  - ASHP meeting abstracts--investigational drug procurement;
KW  - National Cancer Institute--drug distribution--investigational drugs;
KW  - Drugs, investigational--regulations--procurement, NCI;
KW  - Protocols--drugs, investigational--procurement, NCI;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Basset-Séguin, Nicole
AU  - Caughman, S. Wright
AU  - Yancey, Kim B.
T1  - A-431 Cells and Human Keratinocytes Synthesize and Secrete the Third Component of Complement.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1990/12//
VL  - 95
IS  - 6
M3  - Article
SP  - 621
EP  - 625
SN  - 0022202X
AB  - Biosynthetic radiolabeling studies demonstrate that A-431 cells, a human epidermoid carcinoma cell line, and human keratinocytes synthesize and secrete C3 as two disulfide-linked polypeptide chains of 120 and 75 kD. Moreover, epithelial cell-derived C3 co-migrates in SDS-PAGE with that produced by HepG2 cells, a human hepatoma cell line previously used to elucidate complement component biosynthesis. Pulse-chase studies in A-431 cells demonstrate that epithelial cell-derived C3 is produced as a 195-kD precursor molecule, pro-C3, which is processed intracellularly by limited proteolysis into 120- and 75-kD C3 alpha and beta chains. Comparative studies demonstrate that A-431 cell-derived C3 is synthesized, processed, and secreted in parallel but in lower quantity than that produced by HepG2 cells. Treatment of biosynthetically labeled A-431 cell culture supernatants with normal human serum and zymosan produces C3 alpha chain cleavage and specific C3 fragments that are not present in control culture supernatants treated with heat-inactivated human serum and zymosan. Northern blot analysis of total cellular RNA extracted from A-431 cells, human keratinocytes, and HepG2 cells reveals qualitative identity of a 5.1-kb C3 rnRNA species in these three cell types. Epithelial cell-derived C3 may play an important role in local inflammatory and immunologic reactions including such reactions in human skin. Moreover, epithelial cell C3 synthesis may have direct relevance to the recent demonstration of C3d,g within selected normal primate epithelial basement membranes, including epidermal basement membrane. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - CELLS
KW  - COMPLEMENT (Immunology)
KW  - CELL lines
KW  - BASAL lamina
KW  - EPITHELIAL cells
N1  - Accession Number: 12513524; Basset-Séguin, Nicole 1 Caughman, S. Wright 2 Yancey, Kim B. 1; Affiliation:  1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Dec90, Vol. 95 Issue 6, p621; Subject Term: KERATINOCYTES; Subject Term: CELLS; Subject Term: COMPLEMENT (Immunology); Subject Term: CELL lines; Subject Term: BASAL lamina; Subject Term: EPITHELIAL cells; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12513524
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12513524&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Flynn, J. L.
AU  - Weiss, W. R.
AU  - Norris, K. A.
AU  - Seifert, H. S.
AU  - Kumar, S.
AU  - So, M.
T1  - Generation of a cytotoxic T-lymphocyte response using a <em>Salmonella</em> antigen-delivery system.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1990/12//
VL  - 4
IS  - 12
M3  - Article
SP  - 2111
EP  - 2118
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - We have constructed a general-use vector for the cloning and stable expression of foreign genes in the chromosome of attenuated <em>Salmonella typhimurium</em>. Using this chromosomal expression vector (CEV), we expressed the circumsporozoite (CS) gene of the mouse malaria Plasmodium <em>yoelii</em> in an <em>aroA S. typhimurium</em> strain. Mice immunized with CS-expressing <em>Salmonella</em> recombinants mount a CS-specific cytotoxic T-lymphocyte (CTL) response. This is the first demonstration that attenuated <em>Salmonella</em> can elicit a specific CTL response to a foreign protein in mice. The ability to easily and stably express foreign genes from the <em>Salmonella</em> chromosome and the generation of specific CTL greatly expands the potential of <em>Salmonella</em> as an antigen-delivery system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cloning
KW  - Gene expression
KW  - Chromosomes
KW  - Salmonella typhimurium
KW  - Plasmodium
N1  - Accession Number: 15945969; Flynn, J. L. 1,2; Weiss, W. R. 3; Norris, K. A. 1; Seifert, H. S. 4; Kumar, S. 5; So, M. 1; Affiliations: 1: Department of Molecular Biology, Research institute of Scripps Clinic, La Jolla, California 92037, USA; 2: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA; 3: Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814, USA; 4: Department of Microbiology and Immunology, Northwestern University School of Medicine, Chicago, Illinois 60611, USA; 5: 'Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Dec1990, Vol. 4 Issue 12, p2111; Subject Term: Cloning; Subject Term: Gene expression; Subject Term: Chromosomes; Subject Term: Salmonella typhimurium; Subject Term: Plasmodium; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Powell, B. S.
AU  - Kado, C. I.
T1  - Specific binding of VirG to the <em>vir</em> box requires a C- terminal domain and exhibits a minimum concentration threshold.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1990/12//
VL  - 4
IS  - 12
M3  - Article
SP  - 2159
EP  - 2166
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The positive regulatory protein VirG from the virulence region of the Ti plasmid of <em>Agrobacterium tumefaciens</em> was first demonstrated to possess DNA-binding capabilities using chromatographicalty purified protein and in <em>vitro</em> assays (Powell <em>et al</em>., 1989). This paper is an extension of that research and presents evidence on the <em>in vivo</em> DNA-binding properties of VirG using a transcription interference assay. VirG protein bound specifically to a <em>'vir box'</em> response element and repressed transcription of a <em>lacZ</em> reporter gene, but increased transcription in the absence of a <em>vir box</em>. A biphasic response in specific DNA-binding was observed upon increasing <em>virG</em> expression, suggesting that specific binding was co-operatively affected by protein concentration. Certain TrpE-VirG hybrid proteins also bound the <em>vir</em> box, but required sequences distal to amino acid Arg-118 of the VirG polypeptide. These data further localize a DNA-binding domain within VirG, and support a modified model for the regulation of virulence genes in which <em>trans</em>-phosphorylation by the coregulator VirA functions to stabilize specific DNA-binding by low concentrations of VirG, resulting in gene activation. Otherwise, at high concentrations, VirG promotes expression of the virulence regulon without assistance from VirA as was shown previously (Rogowsky <em>et al</em>., 1987). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Virulence (Microbiology)
KW  - Agrobacterium tumefaciens
KW  - DNA-binding proteins
KW  - Gene expression
KW  - Peptide hormones
N1  - Accession Number: 15946110; Powell, B. S. 1; Kado, C. I. 1,2; Affiliations: 1: Department of Plant Pathology, University of California, Davis, California 95616, USA; 2: Laboratory of Chromosome Biology, National Cancer Institute -- FCRDC, Frederick, Maryland 21702, USA; Issue Info: Dec1990, Vol. 4 Issue 12, p2159; Thesaurus Term: Virulence (Microbiology); Subject Term: Agrobacterium tumefaciens; Subject Term: DNA-binding proteins; Subject Term: Gene expression; Subject Term: Peptide hormones; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Sctiooler, Carmi
T1  - The Individual in Japanese History: Parallels to and Divergences from the European Experience.
JO  - Sociological Forum
JF  - Sociological Forum
Y1  - 1990/12//
VL  - 5
IS  - 4
M3  - Article
SP  - 569
PB  - Wiley-Blackwell
SN  - 08848971
AB  - This paper shows that Japan underwent a sequence of historical periods during which the level of technical development and the place of the individual in society paralleled that of similar periods in Europe. Particular attention is paid to 16th-century Japan, a period remarkably similar to the European Renaissance in its individualism and socioeconomic and cultural vitality. In both Japan and Western Europe, this renaissance followed the breakdown of an imperium and its replacement by a feudal system. The historical parallel continues with those parts of Europe in which absolutist governments were successfully imposed, since Japan underwent a similar phenomenon, accompanied by a similar decline in individualism and in technological development. Although no definitive conclusions can be reached, the paper explores the implications of these parallels for our understanding of both Japan and the general historical and psychological processes involved in the growth of individualism and technology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Sociological Forum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTORICAL sociology
KW  - ANTHROPOLOGY
KW  - SOCIAL evolution
KW  - SOCIOLOGY
KW  - INDIVIDUALISM
KW  - SELF-interest
KW  - economic development.
KW  - European history
KW  - individualism
KW  - Japanese history
N1  - Accession Number: 10797082; Sctiooler, Carmi 1; Affiliation:  1: Laboratory of Socio-environmental Studies, National Institute of Mental Health, Room B1A-14, Federal Building, 7550  Wisconsin Avenue, Bethesda, Maryland 20892.; Source Info: Dec90, Vol. 5 Issue 4, p569; Subject Term: HISTORICAL sociology; Subject Term: ANTHROPOLOGY; Subject Term: SOCIAL evolution; Subject Term: SOCIOLOGY; Subject Term: INDIVIDUALISM; Subject Term: SELF-interest; Author-Supplied Keyword: economic development.; Author-Supplied Keyword: European history; Author-Supplied Keyword: individualism; Author-Supplied Keyword: Japanese history; Number of Pages: 26p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1992-30543-001
AN  - 1992-30543-001
AU  - Szallasi, Arpad
AU  - Szallasi, Zoltan
AU  - Blumberg, Peter M.
T1  - Permanent effects of neonatally administered resiniferatoxin in the rat.
JF  - Brain Research
JO  - Brain Research
JA  - Brain Res
Y1  - 1990/12//
VL  - 537
IS  - 1-2
SP  - 182
EP  - 186
CY  - Netherlands
PB  - Elsevier Science
SN  - 0006-8993
SN  - 1872-6240
N1  - Accession Number: 1992-30543-001. PMID: 2085772 Partial author list: First Author & Affiliation: Szallasi, Arpad; NIH National Cancer Institute Lab of Cellular Carcinogenesis & Tumor Promotion, Molecular Mechanisms of Tumor Promotion Section, Bethesda, MD, US. Release Date: 19920901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dosages; Drug Tolerance; Infants (Animal); Neurotoxins; Toxicity. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Page Count: 5. Issue Publication Date: Dec, 1990. 
AB  - Determined the effects of the highest tolerated dose of resiniferatoxin (RTX) administered to rat neonates RTX is a phorbol-related diterpene that functions as a capsaicin analog but differs from capsaicin in potency and selectivity. Analysis was performed when Ss were 6–8 wks old. None of the adult Ss given RTX as newborns responded to the intra-ocular instillation of a 0.1% capsaicin solution, although Ss treated neonatally with vehicle only showed a number of protective eye-wiping movements. RTX was an ultrapotent capsaicin analog in adult Ss and was a very potent sensorotoxin in neonates. RTX appears to affect the primary sensory neurons. At biologically effective doses of RTX, aspecific toxic effects are unlikely to occur. RTX may be a valuable probe for exploring the mechanisms of capsaicin-induced desensitization to noxious chemical stimuli. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - highest tolerated dose of neonatal resiniferatoxin
KW  - sensorotoxicity
KW  - newborn rats
KW  - 1990
KW  - Drug Dosages
KW  - Drug Tolerance
KW  - Infants (Animal)
KW  - Neurotoxins
KW  - Toxicity
KW  - Rats
KW  - 1990
DO  - 10.1016/0006-8993(90)90356-G
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UR  - ORCID: 0000-0001-5395-7509
UR  - 
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - Gen
ID  - 9999-23727-000
AN  - 9999-23727-000
AU  - Maser, Jack D.
AU  - Kaelber, Charles
AU  - Weise, Richard E.
T1  - International Survey for the Use of DSM-III and DSM-III-R
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1991///
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-23727-000. Partial author list: First Author & Affiliation: Maser, Jack D.; National Institute of Mental Health, Division of Clinical Research, Rockville, Maryland, United States. Release Date: 20131007. Correction Date: 20151109. Instrument Type: Survey. Test Location: Appendix, Page 279. Test Format: The questionnaire utilizes a variety of response formats: open-ended, multiple-choice, Likert-type scales, and yes/no.. Language: English. Constructs: Use of and Attitudes toward DSM-III and DSM-III-R; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). 
AB  - Purpose: The International Survey for the Use of DSM-III and DSM-III-R assesses mental health professionals' use and opinions of the DSM-III and DSM-III-R.
AB  - Description: The International Survey for the Use of DSM-III and DSM-III-R (Maser, Kaelber, & Weise, 1991) was developed within the context of an international study of the use of and attitudes toward the DSM-III and DSM-III-R. The 16-item questionnaire asseses how mental health professionals use the DSM-III and DSM-III-R and their attitudes toward these classification systems. The questionnaire also gathers information about the respondents in terms of country represented, time spent in professional activities, training, orientation, and types of patients seen. A variety of response formats are utilized. The questionnaire was revised several times on the basis of the comments of physicians and doctoral-level psychologists. Psychometric properties were not reported in the test development article. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - International Survey for the Use of DSM-III and DSM-III-R
KW  - Surveys
KW  - Test Development
U5  - International Survey for the Use of DSM-III and DSM-III-R [Test Development]International use and attitudes toward DSM-III and DSM-III—R: Growing consensus in psychiatric classification. (AN: 1991-34522-001 from PsycINFO) Maser, Jack D.; Kaelber, Charles; Weise, Richard E.; Aug, 1991. Source: Journal of Abnormal Psychology. 100(3), American Psychological Association, US; Aug, 1991; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Experts in Survey Research Keywords: International Survey for the Use of DSM-III and DSM-III-R; Surveys; Test Development; Subjects: Diagnostic and Statistical Manual; Surveys; Test Construction;
DO  - 10.1037/t23727-000
L3  - Full; Full text; 999923727_full_001.pdf
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Bayne, K.
AU  - Mainzer, H.
AU  - Dexter, S.
AU  - Campbell, G.
AU  - Yamada, F.
AU  - Suomi, S.
T1  - The Reduction of Abnormal Behaviors in Individually Housed Rhesus Monkeys (Macaca mulatta) With a Foraging/Grooming Board.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1991/01//
VL  - 23
IS  - 1
M3  - Article
SP  - 23
EP  - 35
SN  - 02752565
AB  - A new environmental enrichment device, termed a "foraging/grooming board," was presented to 8 individually housed rhesus monkeys for the explicit purpose of reducing the level of aberrant behaviors manifested by these animals. The device consisting of a piece of plexiglass covered with artificial fleece, had particles of food treats rubbed into it and was attached to the outside of each animal's home cage. All animals foraged from the board to the point that a significant reduction in the level of abnormal behavior was noted. Most animals also groomed the fleece covering the board, utilizing the same motor patterns that would be directed toward grooming another monkey. These boards are inexpensive to construct and easy to sanitize, and do not require placing animal facility personnel at risk to maintain them. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHESUS monkey -- Behavior
KW  - ANIMAL behavior
KW  - ANIMAL psychology
KW  - PRIMATES
KW  - ZOOLOGY
KW  - aberrnt behavior
KW  - environmental enrichment
KW  - fleece
N1  - Accession Number: 12360427; Bayne, K. 1 Mainzer, H. 1 Dexter, S. 1 Campbell, G. 2 Yamada, F. 2 Suomi, S.; Affiliation:  1: Office of Animal Care and Use, Office of the Director, Laboratory of Statistical and Mathematical Methodology, Division of Computer Research and Technology  2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, National Institutes of Health; Source Info: 1991, Vol. 23 Issue 1, p23; Subject Term: RHESUS monkey -- Behavior; Subject Term: ANIMAL behavior; Subject Term: ANIMAL psychology; Subject Term: PRIMATES; Subject Term: ZOOLOGY; Author-Supplied Keyword: aberrnt behavior; Author-Supplied Keyword: environmental enrichment; Author-Supplied Keyword: fleece; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mantovani, V.
AU  - Corazza, G. R.
AU  - Angelini, G.
AU  - Delfino, L.
AU  - Frisoni, M.
AU  - Mirri, P.
AU  - Valentini, R. A.
AU  - Barboni, P.
AU  - Gasbarrini, G.
AU  - Ferrara, G. B.
T1  - Molecular analysis of HLA-DQ A alleles in coeliac disease lack of a unique disease-associated sequence.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1991/01//
VL  - 83
IS  - 1
M3  - Article
SP  - 74
EP  - 78
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Susceptibility to coeliac disease is strongly associated with some HLA class II antigens, encoded by the HLA-D region. Since the HLA-DQ locus seems to be primarily involved, we have analysed by polymerase chain reaction amplification and allele-specific oligonucleotide hybridization the most polymorphic region of the HLA-DQ Al gene. No difference was observed between the 20 coeliac patients and 20 HLA-D-matched healthy controls who took part in the study. Furthermore, in patients and controls, the restriction fragment length polymorphism analysis of the HLA-DQ A1 gene using the restriction enzyme Bg/II did not disclose any specific disease-associated fragment. Our results are not consistent with a unique DQ A coeliac disease-associated sequence, but rather with the hypothesis that some polymorphic residues or allelic hypervariable regions, although found also in the normal population, can predispose to coeliac disease due to their higher frequency in this condition. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELIAC disease
KW  - ANTIGENS
KW  - HLA class II antigens
KW  - DNA polymerases
KW  - HYBRIDIZATION
KW  - OLIGONUCLEOTIDES
KW  - HLA restriction fragment length polymorphism polymerase chain reaction coeliac disease
N1  - Accession Number: 15987977; Mantovani, V. 1 Corazza, G. R. 2 Angelini, G. 3 Delfino, L. 3 Frisoni, M. 1 Mirri, P. 1 Valentini, R. A. 1 Barboni, P. 1 Gasbarrini, G. 1 Ferrara, G. B. 3; Affiliation:  1: Tissue Typing Laboratory, Malpighi Hospital, Bologna.  2: I Department of Medical Pathology, S. Orsola University Hospital, Bologna.  3: National Cancer Institute, Genova, Italy.; Source Info: Jan1991, Vol. 83 Issue 1, p74; Subject Term: CELIAC disease; Subject Term: ANTIGENS; Subject Term: HLA class II antigens; Subject Term: DNA polymerases; Subject Term: HYBRIDIZATION; Subject Term: OLIGONUCLEOTIDES; Author-Supplied Keyword: HLA restriction fragment length polymorphism polymerase chain reaction coeliac disease; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
ID  - 1991-98798-024
AN  - 1991-98798-024
AU  - Myers, Hector F.
AU  - Wohlford, Paul
ED  - Myers, Hector F.
ED  - Wohlford, Paul
ED  - Guzman, L. Philip
ED  - Echemendia, Ruben J.
ED  - Myers, Hector F., (Ed)
ED  - Wohlford, Paul, (Ed)
ED  - Guzman, L. Philip, (Ed)
ED  - Echemendia, Ruben J., (ORCID: 0000-0001-6116-8462), (Ed)
T1  - Recommendations From the National Conference on Clinical Training in Psychology for Ethnic Minorities.
T2  - Ethnic minority perspectives on clinical training and services in psychology.
Y1  - 1991///
SP  - 157
EP  - 159
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-120-5
AD  - Myers, Hector F., Department of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, US, 90024
N1  - Accession Number: 1991-98798-024. Partial author list: First Author & Affiliation: Myers, Hector F.; University of California, Los Angeles, Department of Psychology, Los Angeles, CA, US. Release Date: 19920601. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-120-5, Paperback. Language: English. Major Descriptor: Clinical Psychology Graduate Training; Minority Groups; Scientific Communication. Classification: Professional Education & Training (3410). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 3. 
AB  - National demographic data indicate dramatic increases in the U.S. ethnic minority population. Much of this growth results from the infusion of immigrants from Latin America and Southeast Asia. Recent epidemiological data also note the disproportionately high need for public sector mental health services among ethnic minorities, especially inner-city youth and young adults. Consequently, the need for well-trained ethnic minority mental health professionals continues to be acute. Also, the number of new available faculty positions in psychology are projected to increase significantly during the next decade. If we are to address the critical need for more minority psychologists on the faculty of clinical training programs, we must continue to recruit and train large cohorts of ethnic minority psychologists. This chapter articulates the recommendations from the National Conference on Clinical Training in Psychology for Ethnic Minorities and encourages their implementation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - conference
KW  - ethnic minorities
KW  - clinical training programs
KW  - 1991
KW  - Clinical Psychology Graduate Training
KW  - Minority Groups
KW  - Scientific Communication
KW  - 1991
DO  - 10.1037/10102-024
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
AU  - Brown, Martin
AU  - Philips, Peter
AD  - National Cancer Institute and Howard U
AD  - U UT
A2  - Kanth, Rajani K.
A2  - Hunt, E. K.
T1  - Competition, Racism, and the Substitution of White Women for Chinese Men in Nineteenth-Century California Manufacturing
T2  - Explorations in political economy: Essays in criticisms
PB  - Savage, Md.:
PB  - Rowman and Littlefield
Y1  - 1991///
SP  - 173
EP  - 199
N1  - Accession Number: 0339085; Keywords: Racism;  Women; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 199412
KW  - Labor Discrimination          J71
KW  - Economic History: Labor and Consumers, Demography, Education, Health, Welfare, Income, Wealth, Religion, and Philanthropy: U.S.; Canada: Pre-1913          N31
KW  - Economics of Minorities, Races, Indigenous Peoples, and Immigrants; Non-labor Discrimination          J15
KW  - Economics of Gender; Non-labor Discrimination          J16
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Dennis, Deborah L.
AU  - Levine, Irene S.
AU  - Osher, Fred C.
AD  - Policy Research Associates
AD  - National Institute of Mental Health
AD  - National Institute of Mental Health
T1  - The Physical and Mental Health Status of Homeless Adults
JO  - Housing Policy Debate
JF  - Housing Policy Debate
Y1  - 1991///
VL  - 2
IS  - 3
SP  - 815
EP  - 835
SN  - 10511482
N1  - Accession Number: 0287517; Keywords: Homeless; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199306
N2  - This paper reviews recent research on the physical and mental health status of homeless single adults and briefly summarizes definitional, sampling, and measurement problems. It presents findings from research examining the physical health status of homeless adults; the data suggest that homelessness places people at greater risk for specific health problems and also complicates treatment. The authors then review findings on the mental health status of homeless adults from several methodologically rigorous studies that carefully define and measure mental illness among the homeless population. The final section discusses what is known about the short- and long-term service needs of the physically and mentally disabled homeless population.
KW  - Measurement and Analysis of Poverty          I32
KW  - Demographic Trends, Macroeconomic Effects, and Forecasts          J11
KW  - General Welfare; Well-Being          I31
L3  - http://www.tandfonline.com/loi/rhpd20
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UR  - http://www.tandfonline.com/loi/rhpd20
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Thompson, H.L.
AU  - Burbelo, P.D.
AU  - Yamada, Y.
AU  - Kleinman, H.K.
AU  - Metcalfe, D.D.
T1  - Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading.
JO  - Immunology
JF  - Immunology
Y1  - 1991/01//
VL  - 72
IS  - 1
M3  - Article
SP  - 144
EP  - 149
PB  - Wiley-Blackwell
SN  - 00192805
AB  - PT18 mast cells and mouse bone marrow-derived mast cells have been shown to adhere and spread when in contact with a laminin substratum. Mouse bone marrow cells, however, first require activation with phorbol myristate acetate (PMA), ionophore, or antigen-specific IgE with antigen in order to exhibit these phenomena. Here, we have studied the interaction of these cells with three active synthetic peptides derived from different domains of laminin. PT18 cells and mouse bone marrow mast cells attached and spread on the 19 amino acid synthetic laminin A chain-derived peptide PA22-2, containing the active five amino acid sequence IKVAV, and this attachment did not require prior activation of the mouse bone marrow mast cells with PMA or IgE plus antigen. These cells did not adhere to the B1 chain peptide YIGSR-NH2 or the RGD-containing peptide from the A chain. PT18 cell adherence to laminin was inhibited by soluble peptide PA22-2, but not by either YIGSR-NH2, the RGD-containing, or control peptides. Antisera to the PA22-2 peptide completely abolished adherence to PA22-2, but only partially inhibited mast cell adherence to laminin. Antibody to the 67,000-32,000 MW laminin-binding protein receptor blocked cell adhesion to laminin and to the active A chain peptide. Thus, mast cell adhesion and spreading on laminin may be mediated by an interaction with the IKVAV sequence on the laminin A chain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cells
KW  - AMINO acids
KW  - BONE marrow cells
KW  - CONNECTIVE tissue cells
KW  - IMMUNE system
KW  - PHORBOLS
KW  - IMMUNOLOGY -- Animal models
KW  - MICE as laboratory animals
N1  - Accession Number: 13385642; Thompson, H.L. 1 Burbelo, P.D. 2 Yamada, Y. 2 Kleinman, H.K. 2 Metcalfe, D.D. 1; Affiliation:  1: The Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases  2: The Laboratory of Development Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1991, Vol. 72 Issue 1, p144; Subject Term: MAST cells; Subject Term: AMINO acids; Subject Term: BONE marrow cells; Subject Term: CONNECTIVE tissue cells; Subject Term: IMMUNE system; Subject Term: PHORBOLS; Subject Term: IMMUNOLOGY -- Animal models; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
AU  - Gwadz, Robert W.
AD  - National Institutes of Health
A2  - American Association for the Advancement of Science, Sub-Saharan Africa Program
T1  - Malaria and Development in Africa: A New Strategy for Research, Training, and Control
T2  - Malaria and development in Africa: A cross-sectoral approach
PB  - Washington, D.C.:
PB  - Author
Y1  - 1991///
SP  - 99
EP  - 103
N1  - Accession Number: 0343069; Keywords: Development; Geographic Descriptors: Africa; Geographic Region: Africa; Publication Type: Collective Volume Article; Update Code: 199412
KW  - Economic Development: Human Resources; Human Development; Income Distribution; Migration          O15
KW  - Health Production          I12
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 2005-09769-006
AN  - 2005-09769-006
AU  - Christison, George W.
AU  - Kirch, Darrell G.
AU  - Wyatt, Richard Jed
T1  - When Symptoms Persist: Choosing Among Alternative Somatic Treatments for Schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1991///
VL  - 17
IS  - 2
SP  - 217
EP  - 245
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Christison, George W., Loma Linda University School of Medicine, Dept. of Psychiatry, P.O. Box 1007, Loma Linda, CA, US, 92354
N1  - Accession Number: 2005-09769-006. PMID: 1679252 Partial author list: First Author & Affiliation: Christison, George W.; Loma Linda Behavioral Medicine Center Hospital, Loma Linda, CA, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dosages; Neuroleptic Drugs; Psychiatric Symptoms; Schizophrenia; Treatment. Classification: Schizophrenia & Psychotic States (3213); Clinical Psychopharmacology (3340). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 29. Issue Publication Date: 1991. 
AB  - Many patients with schizophrenia continue to have significant disabling symptoms despite adequate trials of different types and doses of traditional neuroleptics. Clinicians treating these neuroleptic-resistant patients must look to other treatments in the hope of providing some relief. The literature on many of the alternative treatments is too scanty for firm conclusions. We offer criteria for deciding which treatments may warrant consideration. We review the evidence for the eight treatments we found to meet these criteria and discuss clinical points salient to their use in this population. Although not always conclusive, the data do offer clues for treatment guidelines and an approach to choosing among the available treatments is suggested. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric symptoms
KW  - schizophrenia
KW  - somatic treatments
KW  - neuroleptic drugs
KW  - drug doses
KW  - 1991
KW  - Drug Dosages
KW  - Neuroleptic Drugs
KW  - Psychiatric Symptoms
KW  - Schizophrenia
KW  - Treatment
KW  - 1991
DO  - 10.1093/schbul/17.2.217
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09763-005
AN  - 2005-09763-005
AU  - Kirch, Darrell G.
AU  - Wagman, Althea M. I.
AU  - Goldman-Rakic, Patricia S.
T1  - Commentary: The Acquisition and Use of Human Brain Tissue in Neuropsychiatric Research.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1991///
VL  - 17
IS  - 4
SP  - 593
EP  - 596
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kirch, Darrell G., National Institute of Mental Health, 5600 Fishers Ln., Rm. 10-105, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09763-005. PMID: 1805352 Partial author list: First Author & Affiliation: Kirch, Darrell G.; Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Brain; Neuropsychology. Classification: Neuropsychology & Neurology (2520). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: 1991. 
AB  - Witelson and McCulloch (see record [rid]2005-09763-004[/rid]) report on the establishment of a collection of normal human brain tissue that was secured through a unique method of premortem and postmortem assessments. Their work highlights the growing need in neuroscientific research for carefully characterized collections of human brain tissue from both normal control subjects and patients with specific neuropsychiatric disorders. Brain tissue of this type, however, has not been readily available. Patients with mental disorders may not be competent to consent to a postmortem brain donation; other obstacles include various socioeconomic and legal impediments to autopsies. In addition, a number of methodologic issues exist regarding human brain tissue collections, including the problem of standardized postmortem diagnostic assessment and difficulty in establishing uniform procedures for processing formalin-fixed and frozen tissue. Various proposals to enhance brain-tissue collections are discussed. These include the establishment of networks for tissue donation and use, the linking of ultimate postmortem brain tissue collection to prospective clinical studies, and promulgation of standardized procedures for methods of postmortem diagnosis and tissue handling. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - premortem measurement
KW  - postmortem measurement
KW  - human brain
KW  - structure function relationship
KW  - human behavior
KW  - neuropsychology
KW  - 1991
KW  - Brain
KW  - Neuropsychology
KW  - 1991
DO  - 10.1093/schbul/17.4.593
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - KLINE, RICHARD L.
AU  - BROTHERS, THOLA
AU  - HALSEY, NEAL
AU  - BOULOS, REGINALD
AU  - LAIRMORE, MICHAEL D.
AU  - QUINN, THOMAS C.
T1  - Evaluation of enzyme immunoassays for antibody to human T-lymphotropic viruses type I/II.
JO  - Lancet
JF  - Lancet
Y1  - 1991/01/05/
VL  - 337
IS  - 8732
M3  - Article
SP  - 30
EP  - 33
PB  - Lancet
SN  - 00995355
AB  - Compares the reliability, sensitivity and specificity of seven commercially available enzyme immunoassays for antibody to human T-lymphotropic virus type I/II, as assessed by western blot and radioimmunoprecipitation assays.  Materials and methods; Results; Discussion.
KW  - MEDICAL research
N1  - Accession Number: 9101280141; KLINE, RICHARD L. 1 BROTHERS, THOLA 2 HALSEY, NEAL 3 BOULOS, REGINALD 4 LAIRMORE, MICHAEL D. 5 QUINN, THOMAS C. 1; Affiliation:  1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA.  2: Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore USA.  3: Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland USA.  4: Centers for Development and Health, Port-au-Prince, Haiti USA.  5: Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, Georgia USA.; Source Info: 1/5/1991, Vol. 337 Issue 8732, p30; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3018
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - WATSON, ALAN R.
AU  - BROOK, C. G. D.
AU  - WILD, RICHARD
AU  - COLE, T. J.
AU  - DAVIES, P. S. W.
AU  - RAVUSSIN, ERIC
AU  - STOLL, BASIL A.
AU  - WALKER, JOANNA M.
AU  - WALKER, SUSAN
AU  - GRANTHAM-MCGREGOR, SALLY
AU  - POWELL, CHRISTINE
T1  - Safety of growth hormone.
JO  - Lancet
JF  - Lancet
Y1  - 1991/01/12/
VL  - 337
IS  - 8733
M3  - Article
SP  - 108
EP  - 110
PB  - Lancet
SN  - 00995355
N1  - Accession Number: 43455404; WATSON, ALAN R. 1 BROOK, C. G. D. 2 WILD, RICHARD COLE, T. J. 3 DAVIES, P. S. W. 3 RAVUSSIN, ERIC 4 STOLL, BASIL A. 5 WALKER, JOANNA M. 6 WALKER, SUSAN 7 GRANTHAM-MCGREGOR, SALLY 7 POWELL, CHRISTINE 7; Affiliation:  1: City Hospital, Hucknall Road  2: Department of Medicine. UCMSM. Cobbold Laboratories, Middlesex Hospital  3: University of Cambridge and Medical Research Council, Dunn Nutritional Laboratory  4: Clinical Diabetes and Nutrition Section, National Institutes of Health  5: Department of Oncology, St Thomas' Hospital  6: Department of Paediatrics, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital  7: Tropical Metabolism Research Unit, University of the West Indies; Source Info: 1/12/1991, Vol. 337 Issue 8733, p108; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 3855
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MANNS, ANGELA
AU  - MURPHY, EDWARD L.
AU  - WILKS, RAINFORD J.
AU  - HAYNES, GRACE
AU  - FIGUEROA, J. PETER
AU  - HANCHARD, BARRIE
AU  - PALKER, THOMAS J.
AU  - BLATTNER, WILLIAM A.
T1  - Early antibody profile during HTLV-I seroconversion.
JO  - Lancet
JF  - Lancet
Y1  - 1991/01/19/
VL  - 337
IS  - 8734
M3  - Article
SP  - 181
EP  - 182
PB  - Lancet
SN  - 00995355
N1  - Accession Number: 43455558; MANNS, ANGELA 1 MURPHY, EDWARD L. 2 WILKS, RAINFORD J. 3 HAYNES, GRACE 4 FIGUEROA, J. PETER 5 HANCHARD, BARRIE 6 PALKER, THOMAS J. 7 BLATTNER, WILLIAM A. 8; Affiliation:  1: National Cancer Institute, Bethesda, Maryland 20892, USA  2: San Francisco General Hospital  3: University of the West Indies, Kingston, Jamaica  4: National Transfusion Service, Kingston, Jamaica  5: Ministry of Health, Kingston, Jamaica  6: University of the West Indies  7: Duke University, Durham, North Carolina  8: National Cancer Institute; Source Info: 1/19/1991, Vol. 337 Issue 8734, p181; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 808
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lakso, Merja
AU  - Masaki, Ryuichi
AU  - Noshiro, Mitsuhide
AU  - Negishi, Masahiko
T1  - Structures and characterization of sex-specific mouse cytochrome <em>P</em>-450 genes as members within a large family.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/01/30/
VL  - 195
IS  - 2
M3  - Article
SP  - 477
EP  - 486
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We characterized two female-specific testosterone 16α-hydroxylase mouse cytochrome P-450 genes, 16αoh-a and 16αoh-b. Gene 16αoh-a, consisting of nine exons, is approximately 38 kbp in size. The exon sequence of this P-450 gene is identical to cDNA pf26 nucleotide sequence [Noshiro, M., Lakso. M., Kawajiri, K. & Negishi, M. (1988) Biochemistry 27, 6434-6443], which encodes female-specific testosterone 16α-hydroxylase regulated by the murine Rip locus. Gene 16αoh-b, containing nine exons with the same junctions as the 16αoh-a, spans at least 20 kbp, and encodes a cytochrome P-450 whose deduced amino acid sequence is 90% similar to the hydroxylase. Nucleotide sequences revealed that duplication of the two genes occurred 4-22 million years ago, and that the 5' duplication boundary is located 1336 bp upstream from the putative transcription-start site. In the flanking regions of both genes, there is a long stretch (100 bp) of CA repeats in addition to other motifs, including TATA box, glucocorticoid-response-element-core and Simian-virus-40-enhancer sequences and IgG light-chain gene promoter. We isolated many genomic DNA clones which contain exon 1 sequences, and compared their restriction maps, cross-hybridization and nucleotide sequences. The results indicate that these genomic clones represent closely related genes in the 16αoh family with a minimum of 16 members, which is further divided into classes a, b and c. 16αoh-a and 16αoh-b belong to the first and second classes, respectively. Moreover, extensive segmental gene conversion and nonreciprocal recombination were noted among the genes, particularly among those in class b, All genes in that class contain the tong ATTT repeat sequences in intron 1, which may have triggered a rapid gene conversion and/or stabilize the duplicated genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOCHROME P-450
KW  - TESTOSTERONE
KW  - NUCLEOTIDE sequence
KW  - EXONS (Genetics)
KW  - BIOCHEMISTRY
KW  - CYTOCHROMES
N1  - Accession Number: 13684320; Lakso, Merja 1 Masaki, Ryuichi 1 Noshiro, Mitsuhide 1 Negishi, Masahiko 1; Affiliation:  1: Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA; Source Info: 1/30/91, Vol. 195 Issue 2, p477; Subject Term: CYTOCHROME P-450; Subject Term: TESTOSTERONE; Subject Term: NUCLEOTIDE sequence; Subject Term: EXONS (Genetics); Subject Term: BIOCHEMISTRY; Subject Term: CYTOCHROMES; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Vecchio, Silvana
AU  - Mansi, Luigi
AU  - Petrillo, Antonella
AU  - Camera, Luigi
AU  - Sofia, Matteo
AU  - Marra, Alberto
AU  - Carratú, Luigi
AU  - Salvatore, Marco
T1  - Endobronchial administration of iodine-131 B72.3 monoclonal antibody in patients with lung cancer.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1991/02//
VL  - 18
IS  - 2
M3  - Article
SP  - 129
EP  - 132
SN  - 03406997
N1  - Accession Number: 71144138; Vecchio, Silvana 1 Mansi, Luigi 1 Petrillo, Antonella 1 Camera, Luigi 1 Sofia, Matteo 2 Marra, Alberto 2 Carratú, Luigi 2 Salvatore, Marco 1; Affiliation:  1: Nuclear Medicine Department, National Cancer Institute and Institute of Nuclear Medicine, II School of Medicine, Via S. Pansini, 5  2: Pulmonary Medicine, II School of Medicine, Via Bianchi I-80131 Naples Italy; Source Info: Feb1991, Vol. 18 Issue 2, p129; Number of Pages: 4p; Document Type: Article
L3  - 10.1007/BF00950759
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Larson, David B.
AU  - Lyons, John S.
AU  - Hohmann, Ann A.
AU  - Beardsley, Robert S.
AU  - Hidalgo, Julia
T1  - PSYCHOTROPICS PRESCRIBED TO THE US ELDERLY IN THE EARLY AND MID 1980s: PRESCRIBING PATTERNS OF PRIMARY CARE PRACTITIONERS, PSYCHIATRISTS, AND OTHER PHYSICIANS.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1991/02//
VL  - 6
IS  - 2
M3  - Article
SP  - 63
EP  - 70
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - Primary care practitioners are significant providers of mental health services to older Americans. The most common mental health service provided by primary care practitioners to this segment of the population is psychotropic drugs. A US national data base was analyzed to compare the psychotropic prescribing patterns of primary care practitioners with psychiatrists and other office-based specialists in both the early and mid 1980s. Prescribing patterns for six different classes of psychotropics were contrasted for patients 55 years of age and older and those 15–54. Results indicate that primary care practitioners were by far the largest prescribers of psychotropics for patients 55 and over at both time periods. This pattern held for most of the individual psychotropic drug classes. In contrast to psychiatrists, primary care practitioners infrequently included a mental disorder diagnosis when they prescribed a psychotropic drug. In addition, primary care practitioners included a mental disorder diagnosis less frequently when they prescribed for the older group than when they prescribed for the younger group. These findings may b¢ used to benefit the training of non-psychiatrist physicians in the diagnosing and treating of mental health disorders found among older adults. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL health services
KW  - MENTAL health
KW  - PSYCHIATRIC drugs
KW  - OLDER people
KW  - MEDICAL care
KW  - UNITED States
KW  - elderly
KW  - primary care
KW  - psychiatrists
KW  - psychotropic medications
N1  - Accession Number: 12085669; Larson, David B. 1 Lyons, John S. 2 Hohmann, Ann A. 1 Beardsley, Robert S. 3 Hidalgo, Julia 4; Affiliation:  1: National Institute of Mental Health, USA  2: Northwestern University Medical School, USA  3: School of Pharmacy, University of Maryland, USA  4: Maryland Department of Health and Mental Hygiene, USA; Source Info: Feb1991, Vol. 6 Issue 2, p63; Subject Term: MENTAL health services; Subject Term: MENTAL health; Subject Term: PSYCHIATRIC drugs; Subject Term: OLDER people; Subject Term: MEDICAL care; Subject Term: UNITED States; Author-Supplied Keyword: elderly; Author-Supplied Keyword: primary care; Author-Supplied Keyword: psychiatrists; Author-Supplied Keyword: psychotropic medications; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Milne, G W A
T1  - Very broad Markush claims; a solution or a problem? Proceedings of a round-table discussion held on August 29, 1990
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1991/02//
VL  - 31
IS  - 1
M3  - Article
SP  - 9
EP  - 30
SN  - 00952338
AB  - This paper presents the transcript of a discussion concerning very broad Markush claims and broad generic terms and their advantages and disadvantages. The problem with Markush claims is a combination of two problems: a problem with the law and a personal problem. The failure of the European Patent Office to declare a policy on Markush claims is also discussed. Experts from several American corporations present views held in these corporations on the issues, as well as case studies on how the issues impact on their policies.
KW  - DATA structures (Computer science)
KW  - EUROPE
KW  - Chemical data
KW  - International
N1  - Accession Number: ISTA2602121; Milne, G W A 1; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: Feb 1991, Vol. 31 Issue 1, p9; Note: Update Code: 2600; Subject Term: DATA structures (Computer science); Subject: EUROPE; Author-Supplied Keyword: Chemical data; Author-Supplied Keyword: International; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Korman, Neil J.
AU  - Eyre, Russell W.
AU  - Zone, John
AU  - Stanley, John R.
T1  - Drug-Induced Pemphigus: Autoantibodies Directed Against the Pemphigus Antigen Complexes Are Present in Penicillamine and Captopril-Induced Pemphigus.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/02//
VL  - 96
IS  - 2
M3  - Article
SP  - 273
EP  - 276
SN  - 0022202X
AB  - Pemphigus is an autoimmune blistering disease characterized by circulating autoantibodies directed against the keratinocyte cell surface. The two variants, pemphigus foliaceus and pemphigus vulgaris, can be distinguished at the molecular level by immunochemical studies. The large majority of patients with pemphigus develop the disease spontaneously; however, there is a small group of patients who develop pemphigus after treatment with certain medications, of which penicillamine and captopril are the best documented. Most patients with drug-induced pemphigus have circulating and/or tissue bound epidermal cell surface autoantibodies; however, the molecular specificity of these autoantibodies has not been studied. We performed immunoprecipitation studies utilizing extracts of 125I-labeled suction blister epidermis and the sera of three patients with drug-induced pemphigus foliaceus (two due to penicillamine and one due to captopril) and one patient with captopril-induced pemphigus vulgaris. We found that the three patients with drug-induced pemphigus foliaceus had circulating autoantibodies that are directed against the pemphigus foliaceus antigen complex and that the one patient with drug-induced pemphigus vulgaris had circulating autoantibodies that are directed against the pemphigus vulgaris antigen complex. This study demonstrates that autoantibodies from drug-induced pemphigus patients have the same antigenic specificity, on a molecular level, as do autoantibodies from other pemphigus patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEMPHIGUS
KW  - AUTOANTIBODIES
KW  - KERATINOCYTES
KW  - IMMUNOCHEMISTRY
KW  - CAPTOPRIL
KW  - IMMUNOGLOBULINS
KW  - ANTIGENS
N1  - Accession Number: 12464471; Korman, Neil J. 1 Eyre, Russell W. 1 Zone, John 2 Stanley, John R. 1; Affiliation:  1: Dermatology Branch , National Cancer Institute, National Institutes of Health, Bethesda, Maryland  2: Department of Medicine (Dermatology) , University of Utah School of Medicine, Salt Lake City. Utah, U.S.A; Source Info: Feb91, Vol. 96 Issue 2, p273; Subject Term: PEMPHIGUS; Subject Term: AUTOANTIBODIES; Subject Term: KERATINOCYTES; Subject Term: IMMUNOCHEMISTRY; Subject Term: CAPTOPRIL; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12464471
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104744493
T1  - Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons.
AU  - Hylden, J L
AU  - Nahin, R L
AU  - Traub, R J
AU  - Dubner, R
Y1  - 1991/02//1991 Feb
N1  - Accession Number: 104744493. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Neurons -- Drug Effects
KW  - Nociceptors -- Drug Effects
KW  - Receptors, Cell Surface -- Physiology
KW  - Spinal Cord -- Drug Effects
KW  - Heterocyclic Compounds
KW  - Analgesics -- Pharmacodynamics
KW  - Animals
KW  - Opioid Peptides -- Pharmacodynamics
KW  - Electric Stimulation
KW  - Inflammation -- Complications
KW  - Inflammation -- Physiopathology
KW  - Neurons -- Physiology
KW  - Physical Stimulation
KW  - Heterocyclic Compounds -- Pharmacodynamics
KW  - Rats
KW  - Receptors, Cell Surface -- Drug Effects
KW  - Receptors, Cell Surface
KW  - Spinal Cord
KW  - Spinal Cord -- Physiology
SP  - 187
EP  - 193
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 44
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1675783.
DO  - 10.1016/0304-3959(91)90136-L
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-05445-033
AN  - 2006-05445-033
AU  - Bookheimer, Susan Y.
T1  - Laterality and the dichotic listening paradigm.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1991/02//
VL  - 36
IS  - 2
SP  - 143
EP  - 144
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05445-033. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bookheimer, Susan Y.; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Acoustics; Auditory Perception; Dichotic Stimulation; Phonetics. Minor Descriptor: Electrophysiology. Classification: Auditory & Speech Perception (2326). Population: Human (10). Reviewed Item: Hugdahl, Kenneth (Ed). Handbook of Dichotic Listening: Theory, Methods, and Research=Chichester, England: Wiley, 1988. 650 pp. $99.00; 1988. References Available: Y. Page Count: 2. Issue Publication Date: Feb, 1991. 
AB  - Reviews the book, Handbook of Dichotic Listening: Theory, Methods, and Research edited by Kenneth Hugdahl (see record [rid]1988-98844-000[/rid]). The volume provides extensive literature reviews, detailed discussions of methodological considerations, and most important, critical and sometimes controversial theoretical discussions. Divided into eight sections, the Handbook covers topics from the phonetic and acoustic effects on laterality to patterns of performance in clinical subgroups. The volume includes excellent sections on neurological and anatomical considerations, children and reading disorders, and psychopathology. There are also reviews of nonverbal dichotic tasks, electrophysiology, and monaural asymmetry. The editing of so complete a volume must have been a formidable task, and generally Hugdahl has done well. Each chapter seems well prepared and well written and flows within the context of each section's overall purpose. The subject index is very disappointing, however. Given the book's length, an elaborate index is a necessity; this one is minimal in scope and contains numerous page listings without specifying content. One hopes that a second edition will correct this problem. Overall, the Handbook of Dichotic Listening makes a very substantial contribution to the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - laterality
KW  - dichotic listening paradigm
KW  - phonetic effects
KW  - acoustic effects
KW  - 1991
KW  - Acoustics
KW  - Auditory Perception
KW  - Dichotic Stimulation
KW  - Phonetics
KW  - Electrophysiology
KW  - 1991
U2  - Hugdahl, Kenneth (Ed). (1988); Handbook of Dichotic Listening: Theory, Methods, and Research; Chichester, England: Wiley, 1988. 650 pp. $99.00; 0-471-91267-0.
DO  - 10.1037/029426
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Raub, William
AU  - Raub, W
T1  - From the National Institutes of Health.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/02/13/
VL  - 265
IS  - 6
M3  - journal article
SP  - 706
EP  - 706
SN  - 00987484
AB  - Presents news related to medicine and health in the U.S. as of February 1991.  Development of a conjugate vaccine that conferred protection against Haemophilus influenzae type b meningitis; Result of a study about the association of menopause and hormone replacement therapy; Risk of HIV-1 transmission among health care workers.
KW  - MEDICINE
KW  - HEALTH
KW  - VACCINATION
KW  - HAEMOPHILUS diseases
KW  - MENOPAUSE -- Hormone therapy
KW  - HIV (Viruses)
KW  - HIV infections -- Transmission
KW  - BACTERIAL meningitis
KW  - PREVENTION
KW  - BACTERIAL antigens
KW  - BACTERIAL vaccines
KW  - HAEMOPHILUS influenzae
KW  - MENOPAUSE
KW  - OCCUPATIONAL diseases
KW  - POLYSACCHARIDES
KW  - SALIVARY glands
KW  - BACTERIAL capsules
KW  - UNITED States
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 10340007; Raub, William Raub, W 1; Affiliation:  1: National Institutes of Health; Source Info: 2/13/91, Vol. 265 Issue 6, p706; Subject Term: MEDICINE; Subject Term: HEALTH; Subject Term: VACCINATION; Subject Term: HAEMOPHILUS diseases; Subject Term: MENOPAUSE -- Hormone therapy; Subject Term: HIV (Viruses); Subject Term: HIV infections -- Transmission; Subject Term: BACTERIAL meningitis; Subject Term: PREVENTION; Subject Term: BACTERIAL antigens; Subject Term: BACTERIAL vaccines; Subject Term: HAEMOPHILUS influenzae; Subject Term: MENOPAUSE; Subject Term: OCCUPATIONAL diseases; Subject Term: POLYSACCHARIDES; Subject Term: SALIVARY glands; Subject Term: BACTERIAL capsules; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chock, Stephen P.
AU  - Rhee, Sue Goo
AU  - Tang, Lily C.
AU  - Schmauder-Chock, Elsa A.
T1  - Linking phospholipase A2 to phospholipid turnover and prostaglandin synthesis in mast cell granules.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/02/14/
VL  - 195
IS  - 3
M3  - Article
SP  - 707
EP  - 713
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Rapid incorporation of exogenous arachidonic acid into phospholipid has been detected in conjunction with eicosanoid synthesis by purified mast cell granules [Chock, S. P. & Schmauder-Chock, E. A. (1988) Biochem. Biophys. Res. Commun. 156, 1308–1315]. The species of phospholipid formed has now been identified primarily as phosphatidylinositol. A calcium-dependent phospholipase A2 has also been detected in the secretory granule. This enzyme, like the cyclooxygenase [Schmauder-Chock, E. A. & Chock, S. P. (1989) J. Hisiochem. Cyzocliem. 37, 1319–1328], appears to bind tightly to the granule matrix components. it is heat resistant and requires millimolar concentration of calcium for optimal activity. It prefers phosphatidylinositol over phosphatidylcholine as substrate. Since the granule contains a large amount of phospholipid, the action of this phospholipase A2 can provide the required substrate for the arachidonic acid cascade. These findings provide the basis for linking phospholipase A2 to the production of eicosanoids during granule exocytosis. Since the granule also contains both an active acylating system that can rapidly reacylate lysophosphatidylinositol to form phosphatidylinositol, and an active phospholipase A2 which hydrolyzes phosphatidylinositol, a rapid turnover involving the fatty acid at the sn-2 position of phosphatidylinositol may occur. These findings are consistent with our postulation that the secretoTry granule is the source and/or the cause of many of the early biochemical events associated with the process of stimulus-secretion coupling. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ARACHIDONIC acid
KW  - LEUKOTRIENES
KW  - PHOSPHOLIPIDS
KW  - EICOSANOIDS
KW  - INFLAMMATION -- Mediators
KW  - BIOCHEMISTRY
N1  - Accession Number: 13675643; Chock, Stephen P. 1 Rhee, Sue Goo 2 Tang, Lily C. 1 Schmauder-Chock, Elsa A. 3; Affiliation:  1: Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC, USA  2: Laboratory of Biochemistry, National Heart, Lund and Blood Institute, National Institutes of Health, Bethesda, MD, USA  3: Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda. MD, USA; Source Info: 2/14/91, Vol. 195 Issue 3, p707; Subject Term: ARACHIDONIC acid; Subject Term: LEUKOTRIENES; Subject Term: PHOSPHOLIPIDS; Subject Term: EICOSANOIDS; Subject Term: INFLAMMATION -- Mediators; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dalton, John P.
AU  - Hudson, Diana
AU  - Adams, John H.
AU  - Miller, Louis H.
T1  - Blocking of the receptor-mediated invasion of erythrocytes by Plasmodium knowlesi malaria with sulfated polysaccharides and glycosaminoglycans.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/02/14/
VL  - 195
IS  - 3
M3  - Article
SP  - 789
EP  - 794
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Invasion of human erythrocytes by Plasmodium knowlesi requires the Duffy blood group antigen. P. knowlesi merozoites synthesize a 135-kDa polypeptide which binds to the Duffy antigen with receptor-like specificity. In this study, we show that the sulfated polysaccharide fucoidan and the glycosaminoglycan dextran sulfate inhibit the binding of the 135-kDa polypeptide to human Duffy-positive and rhesus erythrocytes while the chondroitin sulfates do not. Fucoidan and dextran sulphate also blocked the in vitro invasion of human Duffy b and rhesus erythrocytes cells by P. knowlesi merozoites. These inhibitors were more effective at blocking the binding of the 135-kDa polypeptide to human Duffy b erythrocytes than to rhesus erythrocytes, which correlated with them having a greater inhibitory effect on invasion of merozoites into human than into rhesus erythrocytes. The blocking by these sulfated sugars is not related to charge density on the polysaccharides; fucoidan with a relatively low charge density blocks binding of the 135-kDa polypeptide at 4 μg/ml, while the highly negatively charged chondroitin sulfates do not block binding even at the concentration of I mg/ml. Furthermore, fucoidan- Sepharose bound and removed the 135-kDa polypeptide from parasite culture supernatants with a selectivity equal to that of the Duffy blood group antigen. The negatively charged sulfate groups on fucoidan and dextran sulfate and the conformation in which they are held possibly mimic similarly charged groups on the Duffy antigen which bind the 135-kDa P. knowlesi polypeptide. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ERYTHROCYTES
KW  - BLOOD cells
KW  - MALARIA
KW  - PLASMODIUM
KW  - POLYSACCHARIDES
KW  - GLYCOSAMINOGLYCANS
KW  - MUCOPOLYSACCHARIDES
N1  - Accession Number: 13676880; Dalton, John P. 1,2 Hudson, Diana 1 Adams, John H. 1 Miller, Louis H. 1; Affiliation:  1: Malaria Section, Laboratory of Parasitic Diseases, National institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA  2: School of Biological Sciences, Dublin City University, Ireland; Source Info: 2/14/91, Vol. 195 Issue 3, p789; Subject Term: ERYTHROCYTES; Subject Term: BLOOD cells; Subject Term: MALARIA; Subject Term: PLASMODIUM; Subject Term: POLYSACCHARIDES; Subject Term: GLYCOSAMINOGLYCANS; Subject Term: MUCOPOLYSACCHARIDES; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ershow, Abby G.
AU  - Brown, Linda M.
AU  - Cantor, Kenneth P.
T1  - Intake of Tap Water and Total Water by Pregnant and Lactating Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/03//
VL  - 81
IS  - 3
M3  - Article
SP  - 328
EP  - 334
PB  - American Public Health Association
SN  - 00900036
AB  - Background. Despite theoretically higher requirements for water due to physiologic demands of pregnancy and lactation, little is known of actual ranges of intake in pregnant and lactating women. Methods. Population-based estimates of total water and tapwater intake in women of reproductive age were derived using data from the 1977-78 USDA Nationwide Food Consumption Survey. Three-day average intakes were calculated for 188 pregnant women, 77 lactating women, and 6,201 non-pregnant, non-lactating control women. Results. Total water intake (mean ± SD) was 1,940 ± 686 g/day (median 1,835) for control women, 2,076 ± 743 g/day (median 1,928) for pregnant women and 2,242 ± 658 g/day (median 2,164) for lactating women. Tapwater intake was 1,157 ± 635 g/day (median 1,065) for control women, 1,189 ± 699 g/day (median 1,063) for pregnant women, and 1,310 ± 591 g/day (median 1,330) for lactating women. Total water intake was equal to or greater than 3,000 g/day among 7 percent of pregnant women, and 13 percent of lactating women. Tapwater intake was equal to or greater than 2,000 g/day among 10 percent of control women, 15 percent of pregnant women, and 8 percent of lactating women. Conclusions. These results should be useful in estimating amounts of nutrients and toxic substances that women of reproductive age obtain through the water supply. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WOMEN -- United States
KW  - DRINKING water
KW  - PREGNANT women
KW  - LACTATION
KW  - PREGNANCY
KW  - FOOD consumption
KW  - POISONS
KW  - SURVEYS
KW  - UNITED States
KW  - UNITED States. Dept. of Agriculture
N1  - Accession Number: 9103182553; Ershow, Abby G. 1 Brown, Linda M. 2 Cantor, Kenneth P. 3; Affiliation:  1: Nutritionist, Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892  2: Epidemiologist, Biostatistics Branch, National Cancer Institute  3: Epidemiologist, Environmental Epidemiology Branch, NCI; Source Info: Mar1991, Vol. 81 Issue 3, p328; Subject Term: WOMEN -- United States; Subject Term: DRINKING water; Subject Term: PREGNANT women; Subject Term: LACTATION; Subject Term: PREGNANCY; Subject Term: FOOD consumption; Subject Term: POISONS; Subject Term: SURVEYS; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Agriculture; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jones, Carol J.
AU  - Schiffman, Mark H.
AU  - Kurman, Robert
AU  - Jacob III., Peyton
AU  - Benowitz, Neal L.
T1  - Elevated Nicotine Levels in Cervical Lavages from Passive Smokers.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/03//
VL  - 81
IS  - 3
M3  - Article
SP  - 378
EP  - 379
PB  - American Public Health Association
SN  - 00900036
AB  - One hundred forty-five nonsmokers found to have normal cytologic diagnoses on routine Pap smears were interviewed regarding environmental exposure to tobacco smoke, and a 3 ml saline lavage of the cervix was collected for measurement of cervical nicotine levels by gas chromatography-mass spectroscopy. Nicotine levels tended to be highest among women exposed to tobacco smoke in the home, intermediate in women exposed only outside the home, and lowest in women recalling no exposure (p = 0.001). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIGARETTE smokers
KW  - SMOKING
KW  - IRRIGATION (Medicine)
KW  - NICOTINE
KW  - PAP test
KW  - CYTODIAGNOSIS
KW  - GAS chromatography/Mass spectrometry (GC-MS)
KW  - CERVIX uteri
KW  - TOBACCO smoke
KW  - CIGARETTE smoke
N1  - Accession Number: 9103182560; Jones, Carol J. 1 Schiffman, Mark H. 2 Kurman, Robert 3 Jacob III., Peyton 4 Benowitz, Neal L. 4; Affiliation:  1: EEB/NCI  2: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North 443, Bethesda, MD 20892.  3: Georgetown University Hospital  4: University of California, San Francisco; Source Info: Mar1991, Vol. 81 Issue 3, p378; Subject Term: CIGARETTE smokers; Subject Term: SMOKING; Subject Term: IRRIGATION (Medicine); Subject Term: NICOTINE; Subject Term: PAP test; Subject Term: CYTODIAGNOSIS; Subject Term: GAS chromatography/Mass spectrometry (GC-MS); Subject Term: CERVIX uteri; Subject Term: TOBACCO smoke; Subject Term: CIGARETTE smoke; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Warner, Huber R.
AU  - Baker III, George T.
T1  - THE AGE OF GERONTOLOGY.
JO  - BioScience
JF  - BioScience
Y1  - 1991/03//
VL  - 41
IS  - 3
M3  - Book Review
SP  - 183
EP  - 184
SN  - 00063568
AB  - Reviews the book 'The Biology of Aging,' by John W. Brookbank.
KW  - Aging
KW  - Nonfiction
KW  - Brookbank, John W.
KW  - Biology of Aging, The (Book)
N1  - Accession Number: 10555488; Warner, Huber R. 1; Baker III, George T. 2; Affiliations: 1: National Institute on Aging, National Institutes of Health, Bethesda, MD 20814; 2: Nathan W. and Margaret T. Shock Aging Research Foundation, Silver Spring, MD 20905; Issue Info: Mar1991, Vol. 41 Issue 3, p183; Subject Term: Aging; Subject Term: Nonfiction; Reviews & Products: Biology of Aging, The (Book); People: Brookbank, John W.; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 818
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Friedman, B. S.
AU  - Metcalfe, D. D.
T1  - Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1991/03//
VL  - 21
IS  - 2
M3  - Article
SP  - 183
EP  - 188
PB  - Wiley-Blackwell
SN  - 09547894
AB  - Tixocortol pivalate is a steroid reportedly without significant adrenal-pituitary axis suppression when administered via the gastrointestinal tract. To determine whether this steroid would suppress the gastrointestinal manifestations of systemic mastocytosis, we performed an open clinical trial for safety and efficacy with tixocortal pivalate in four patients for periods of 8-15 weeks. All patients showed a decrease in the symptoms of abdominal pain and frequency of stools. Laboratory parameters of malabsorption improved in parallel with symptom relief. Histopathologic abnormalities of the small bowel improved in one patient. There was no significant suppression of the pituitaryadrenal axis. Two patients developed fluid retention while on tixocortol pivalate, which was attributed to a mineralocorticoid effect. One patient had a fall in AM cortisol. In summary, this study strongly suggests that tixocortol pivalate, when administered orally, has gastrointestinal anti-inflammatory activity comparable lo conventional steroids, but may not be entirely without adrenal-suppressive effect and may lead to fluid retention in some patients. Further studies are warranted to assess the value of tixocortol pivalate in the therapy of inflammatory diseases of the upper gastrointestinal tract. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GASTROINTESTINAL system
KW  - MAST cell disease
KW  - ABDOMINAL pain
KW  - MINERALOCORTICOIDS
KW  - ADRENOCORTICAL hormones
KW  - CLINICAL trials
N1  - Accession Number: 16284103; Friedman, B. S. 1 Metcalfe, D. D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. U.S.A.; Source Info: Mar1991, Vol. 21 Issue 2, p183; Subject Term: GASTROINTESTINAL system; Subject Term: MAST cell disease; Subject Term: ABDOMINAL pain; Subject Term: MINERALOCORTICOIDS; Subject Term: ADRENOCORTICAL hormones; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104750559
T1  - Patterns of variability in the nutrient intake of nutritionally vulnerable pregnant women.
AU  - Launer, L J
AU  - Kardjati, S
AU  - Kusin, J A
AU  - Reed, G F
Y1  - 1991/03//1991 Mar
N1  - Accession Number: 104750559. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 8804070. 
KW  - Dietary Proteins -- Administration and Dosage
KW  - Energy Intake
KW  - Pregnancy
KW  - Dietary Fats -- Administration and Dosage
KW  - Female
KW  - Human
KW  - Indonesia
KW  - Surveys
SP  - 131
EP  - 138
JO  - European Journal of Clinical Nutrition
JF  - European Journal of Clinical Nutrition
JA  - EUR J CLIN NUTR
VL  - 45
IS  - 3
CY  - London, <Blank>
PB  - Nature Publishing Group
SN  - 0954-3007
AD  - Division of Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
U2  - PMID: 2065636.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Ei-Mallakh, Rif S.
AU  - Tasman, Allan
T1  - Recurrent Abortions in a Bulimic: Implications Regarding Pathogenesis.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1991/03//
VL  - 10
IS  - 2
M3  - Article
SP  - 215
EP  - 219
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Despite agreement in psychodynamic formulations that bulimia nervosa results from relatively early developmental difficulties, the role of transitional objects in the syndrome has been debated. We describe the case of a severe bulimic in which repeated pregnancies and abortions fulfilled the same calming function as repeated binging and vomiting. We suggest that the cycle of incorporation and explosion is central to affect regulation and is most compatible wish the view that bulimics use their own bodies as transitional objects. We suggest further that such symptoms represent over determination, and reflect not only primitive deficits in regulation of internal states but also consequent unresolved conflicts. Thus therapy must be flexible enough to deal with both primary and secondary issues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ABORTION
KW  - BULIMIA
KW  - PATIENTS
KW  - TRANSITIONAL objects (Psychology)
KW  - PREGNANCY
KW  - DEPORTATION
KW  - CONFLICT (Psychology)
N1  - Accession Number: 11978101; Ei-Mallakh, Rif S. 1 Tasman, Allan 2; Affiliation:  1: Senior staff fellow, Neuropsychiatry Branch of the National Institute of Mental Health.  2: Professor and director of residency training, Department of Psychiatry. University of Connecticut Health Center.; Source Info: Mar1991, Vol. 10 Issue 2, p215; Subject Term: ABORTION; Subject Term: BULIMIA; Subject Term: PATIENTS; Subject Term: TRANSITIONAL objects (Psychology); Subject Term: PREGNANCY; Subject Term: DEPORTATION; Subject Term: CONFLICT (Psychology); NAICS/Industry Codes: 911320 Immigration services; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Swedo, Susan E.
AU  - Rapoport, Judith L.
T1  - Annotation: Trichotillomania.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1991/03//
VL  - 32
IS  - 3
M3  - Article
SP  - 401
EP  - 409
SN  - 00219630
AB  - The article presents an explanatory note on trichotillomania. Trichotillomania is defined in DSM-III-R as an irresistible urge to pull the hair and a sense of relief after the hair has been plucked. Typically, the hair is pulled singly, rather than in clumps, from the top or sides of the head with resultant bald areas; eyebrows, eyelashes, beard, axillary or pubic hair are sometimes also removed.  Clinical reports indicate two forms of trichotillomania: one, thought to be benign and self-limited, has its onset between 2 and 6 years of age; the other, associated with greater psychopathology, begins during adolescence.
KW  - COMPULSIVE hair pulling
KW  - HAIR
KW  - IMPULSE control disorders
KW  - OBSESSIVE-compulsive disorder
KW  - PATHOLOGICAL psychology
KW  - BALDNESS
KW  - HAIR diseases
N1  - Accession Number: 11911594; Swedo, Susan E. 1 Rapoport, Judith L. 2; Affiliation:  1: Child Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, U.S.A..  2: Department of Health and Human Services, Bethesda, MD 20892, U.S.A..; Source Info: Mar1991, Vol. 32 Issue 3, p401; Subject Term: COMPULSIVE hair pulling; Subject Term: HAIR; Subject Term: IMPULSE control disorders; Subject Term: OBSESSIVE-compulsive disorder; Subject Term: PATHOLOGICAL psychology; Subject Term: BALDNESS; Subject Term: HAIR diseases; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-7610.ep11911594
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ånerud, Å.
AU  - H. Löe
AU  - Boysen, H.
T1  - The natural history and clinical course of calculus formation in man.
JO  - Journal of Clinical Periodontology
JF  - Journal of Clinical Periodontology
Y1  - 1991/03//
VL  - 18
IS  - 3
M3  - Article
SP  - 160
EP  - 170
SN  - 03036979
AB  - This paper describes levels and progression of supra- and subgingival calculus undisturbed by active professional intervention or home care between 1970 and 1985 in Sri Lanka, or when removed at regular intervals between 1969 and 1988 in Norway. in the Sri Lankan tea laborers, both supra- and subgingival calculus formation started before age 14 years. At 40 years of age, all participants and almost all teeth and tooth surfaces had calculus. Tea laborers who both smoked tobacco and chewed betel had significantly higher calculus scores than those who only had one of these habits, and those who neither chewed nor smoked had lowest calculus scores. Teeth with calculus showed a significantly higher rate of loss of attachment than teeth that remained calculus free. For the Norwegians who had enjoyed regular dental care throughout their lives, supragingival calculus did not increase in frequency from adolescence to the forties. Approximately 70% of the interproximal surfaces were calculus free after 40-50 years of age. Subgingival calculus scores, although low, showed some increase with longer times of exposure. On average, each person had 0.4 interproximal surfaces with subgingival calculus as they approached 50 years of age; In this Norwegian population, subgingival calculus had no impact on loss of attachment. (English) [ABSTRACT FROM AUTHOR]
AB  - Cet article décrit les niveaux du tartre susgingival et sous-gingival et sa progression, d'une part en l'absence de modifications dues a time intervention professionnelle active ou aux soins quotidiens, de 1970 à 1985 au Sri Lanka, et d'autre part dans le cas de séances régulières d'élimination du tartre, pendant une période allant de 1969 à 1988 en Norvège. Chez les sujets du Sri Lanka, travailleurs du thé, la formation du tartre, sus-gingival comme sous-gingival, commençait avant l'âge de 14 ans. A l'âge de 40 ans, tous les participants présentaient du tartre ainsi que presque toutes les dents et surfaces dentaires. Les travailleurs du thé qui fumaient du tabac et mâchaient du bétel avaient des scores de tartre significativement plus élevés que ceux qui n'avaient qu'une de ces habitudes, et ceux qui n'avaient ni l'une ni l'autre de ces habitudes avaient les scores du tartre les plus bas. Les dents avec tartre présentaient un taux de perte d'attache significativement plus élevé que les dents qui restaient exemptes de tartre. Pour les Norvégiens ayant profité de soins dentaires réguliers pendant toute la vie, la fréquence du tartre sus-gingival n'augmentait pas de l'adolescence à la quarantaine. Environ 70% des surfaces interproximales étaient exemptes de tartre après 40-50 ans. Les scores du tartre sous-gingival, bien que peu élevés, augmentaient un peu avec la durée de l'exposition. En moyenne, chaque personne avait 0.4 surface interproximale avec tartre sous-gingival à l'approche de la cinquantaine. Dans cette population norvégienne, le tartre sous-gingival n'avait pas de conséquence pour la perte d'attache. (French) [ABSTRACT FROM AUTHOR]
AB  - Diese Veröffentlichung beschreibt das Niveau und das Fortschreiten der von professionellem Eingreifen oder häuslicher Mundpflege ungestörten supra- und subgingivalen Zahnsteinbildung auf Sri Lanka zwischen 1970 und 1988, bzw. in Norwegen, wo der Zahnstein in regelmäßigen Intervallen zwischen 1969 und 1988 entfernt wurde. Bei den Teeplantagenarbeitern auf Sri Lanka begann sowohl supra- als auch subgingival die Zahnsteinbildung vor dem Alter von 14 Jahren. Im Alter von 40 Jahren hatten alle Tellnehmer auf fast allen Zähnen und Zahnflächen Zahnstein. Teeplantagenarbeiter, die sowohl rauchten als auch Betelnüsse kauten, hatten signifikant höhere Zahnsteinwerte als die, die nur eine dieser Angewohnheiten hatten. Die, die weder kauten noch rauchten, hatten die niedrigsten Zahnsteinwerte. Zähne mit Zahnstein zeigten eine signifikant höhere Rate an Attachmentverlust als die Zähne, die zahnsteinfrei blieben. Bei den Norwegern, die während des ganzen Lebens regelmäßige zahnärtzliche Betreuung genossen, vermehrte sich vom Alter des Heranwachsenden bis zum Alter von vierzig Jahren der Zahnstein nicht in der Häufigkeit. Ungefähr 70% der interdentalen Flächen waren nach einem Alter von 40-50 Jahren frei von Zahnstein. Obwohl die subgingivalen Zahnsteinwerte auch niedrig lagen, zeigten sie eine Zunahme im Laufe der Zeit. Im Durchschnitt hatte jede Person bei Erreichen eines Alters von 50 Jahren 0.4 interdentale Flächen mit subgingivalem Zahnstein. In dieser norwegischen Population hatte subgingivaler Zahnstein keine Auswirkung auf den Attachmentverlust. (German) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical Periodontology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTAL calculus
KW  - AGRICULTURAL laborers
KW  - DENTAL care
KW  - SMOKING
KW  - TOBACCO
KW  - DENTISTRY
KW  - calculus.
KW  - natural history
KW  - periodontal disease
N1  - Accession Number: 13458846; Ånerud, Å. 1 H. Löe 1 Boysen, H. 1; Affiliation:  1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA.; Source Info: Mar1991, Vol. 18 Issue 3, p160; Subject Term: DENTAL calculus; Subject Term: AGRICULTURAL laborers; Subject Term: DENTAL care; Subject Term: SMOKING; Subject Term: TOBACCO; Subject Term: DENTISTRY; Author-Supplied Keyword: calculus.; Author-Supplied Keyword: natural history; Author-Supplied Keyword: periodontal disease; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1600-051X.ep13458846
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - The NEO Personality Inventory: Using the Five-Factor Model in Counseling.
JO  - Journal of Counseling & Development
JF  - Journal of Counseling & Development
Y1  - 1991/03//Mar/Apr91
VL  - 69
IS  - 4
M3  - Article
SP  - 367
PB  - Wiley-Blackwell
SN  - 07489633
AB  - Personality psychologists have recently concluded that five major dimensions account for most individual differences in personality traits. The NED Personality Inventory (NEO-PI) is a concise measure of this Five-Factor Model and of some of the important traits that define the factors. Characteristics of the test, features for administration and scoring, and studies of reliability, stability, and validity are summarized. The NEO-PI may be particularly appropriate for use in counseling because it is brief, non psychopathological in content, and sensitive to client strengths as well as weaknesses. We suggest several ways in which the counselor can learn how to use the NED-PI effectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Counseling & Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEO Personality Inventory
KW  - INDIVIDUAL differences
KW  - COUNSELING
KW  - PERSONALITY
KW  - RELIABILITY (Personality trait)
KW  - HUMAN experimentation in psychology
N1  - Accession Number: 9104151256; McCrae, Robert R. 1 Costa Jr., Paul T. 2; Affiliation:  1: Research Psychologist, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland.  2: Chief, Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland.; Source Info: Mar/Apr91, Vol. 69 Issue 4, p367; Subject Term: NEO Personality Inventory; Subject Term: INDIVIDUAL differences; Subject Term: COUNSELING; Subject Term: PERSONALITY; Subject Term: RELIABILITY (Personality trait); Subject Term: HUMAN experimentation in psychology; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Response to Dolliver.
JO  - Journal of Counseling & Development
JF  - Journal of Counseling & Development
Y1  - 1991/03//Mar/Apr91
VL  - 69
IS  - 4
M3  - Article
SP  - 375
PB  - Wiley-Blackwell
SN  - 07489633
AB  - The article presents authors' response to comments on their paper on NEO Personality Inventory used for personality assessment by psychologist Robert H. Dolliver. The author says that Labels for psychological constructs have always been problematic. Rather than create neologisms for familiar variables, these authors have tried to retain familiar names so that their scales could be related easily to existing literature. For decades, personality psychologists have used the term neuroticism to refer to a dimension of normal personality that is characterized primarily by the predisposition to experience psychological distress. Historically, the term was chosen because individuals diagnosed as neurotics scored higher on this dimension, and recent prospective studies have shown that high scorers are at higher risk of developing a variety of psychiatric disorders. However, neuroticism is also crucial for understanding personality within psychiatrically normal groups, because it is related to somatic complaints, psychological well being ways of coping and perceptions of stress. These authors add that perhaps Dolliver think of extraversion in Jungian terms and expect introverts to be introspective, reflective, and more attuned to their inner feelings and thus more able to benefit from therapeutic discussions.
KW  - NEO Personality Inventory
KW  - EXTRAVERSION
KW  - DISTRESS (Psychology)
KW  - PERSONALITY assessment
KW  - PSYCHOLOGISTS
KW  - DOLLIVER, Robert H.
N1  - Accession Number: 9104151258; McCrae, Robert R. 1 Costa Jr., Paul T. 2; Affiliation:  1: Research Psychologist, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland.  2: Chief, Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland.; Source Info: Mar/Apr91, Vol. 69 Issue 4, p375; Subject Term: NEO Personality Inventory; Subject Term: EXTRAVERSION; Subject Term: DISTRESS (Psychology); Subject Term: PERSONALITY assessment; Subject Term: PSYCHOLOGISTS; People: DOLLIVER, Robert H.; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - Introduction.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 1S
EP  - 1S
SN  - 0022202X
AB  - Mastocytosis is a rare disease characterized by an increase in mast cell numbers. The disease, at least in its cutaneous manifestations, has been recognized for over 100 years. During the past decade, however, one have increased an upsurge of interest in it, in part because of increasing awareness of the importance of mast cells in health and disease. Mast cells were traditionally recognized in terms of their primary effector role in the genesis of allergic disease. It is now clear that they participate in a wide variety of processes: release of preformed mediators, such as histamine proteases and heparin.
KW  - MAST cell disease
KW  - MAST cells
KW  - HEALTH
KW  - GENES
KW  - ALLERGY
KW  - DISEASES
N1  - Accession Number: 12468869; Metcalfe, Dean D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p1S; Subject Term: MAST cell disease; Subject Term: MAST cells; Subject Term: HEALTH; Subject Term: GENES; Subject Term: ALLERGY; Subject Term: DISEASES; Number of Pages: 1p; Document Type: Article
L3  - 10.1111/1523-1747.ep12468869
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - Classification and Diagnosis of Mastocytosis: Current Status.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 2S
EP  - 4S
SN  - 0022202X
AB  - Mastocytosis is a disease characterized by an abnormal increase in mast cells. Manifestations of the disease are provoked in large part by the resultant increase in mast cell - derived mediators, which have a variety of local and systemic effects. Mastocytosis is variable in respect to the organ systems involved, clinical manifestations, and association with hematologic diseases. This has suggested the need for an improved classification scheme to allow assessment of prognosis and therapy. The heterogeneity of the disease patterns in mastocytosis strongly suggests that more than one biologic lesion may occur in the developmental sequence that leads to placement of mature mast cells in tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - CELLS
KW  - DISEASES
KW  - TISSUES
KW  - ORGANS (Anatomy)
KW  - PROGNOSIS
N1  - Accession Number: 12468882; Metcalfe, Dean D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p2S; Subject Term: MAST cell disease; Subject Term: CELLS; Subject Term: DISEASES; Subject Term: TISSUES; Subject Term: ORGANS (Anatomy); Subject Term: PROGNOSIS; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12468882
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ketteihut, Brett V.
AU  - Metcalfe, Dean D.
T1  - Pediatric Mastocytosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 15S
EP  - 18S
SN  - 0022202X
AB  - The onset of mastocytosis occurs between birth and 2 years of age in approximately 55% of all cases; an additional 10% develop the disease before the age of 15 years. Mastocytosis in these age groups differs in many respects from mastocytosis that has its onset in adulthood. The typical presentation of pediatric-onset mastocytosis consists of cutaneous manifestations: either a solitary mastocytoma, urticaria pigmentosa, or, less commonly, diffuse cutaneous mastocytosis. Particularly in infants, bullous eruptions may occur. Mastocytosis in infants and children may involve internal organs, including the bone marrow and the gastrointestinal tract, although such manifestations appear to be less common in children than in adults. Plasma histamine levels may be elevated in pediatric- onset mastocytosis. Treatment usually involves the use of H1 and H2 antihistamines to control itching and to control the hypersecretion of gastric acid that may occur. The prognosis for children with mast cell disease is variable; approximately half of the children with urticaria pigmentosa may experience resolution of lesions and symptoms by adolescence. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - ANTIHISTAMINES
KW  - BONE marrow
KW  - DISEASES
KW  - ADULTS
KW  - INFANTS
N1  - Accession Number: 12468942; Ketteihut, Brett V. 1 Metcalfe, Dean D. 2; Affiliation:  1: Division of Allergy and Clinical Immunology , Children's Hospital Medical Center, Elland and Bethesda Avenue, Cincinnati, Ohio, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Mast Cell Physiology Section , Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p15S; Subject Term: MAST cell disease; Subject Term: ANTIHISTAMINES; Subject Term: BONE marrow; Subject Term: DISEASES; Subject Term: ADULTS; Subject Term: INFANTS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12468942
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - The Liver, Spleen, and Lymph Nodes in Mastocytosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 45S
EP  - 46S
SN  - 0022202X
AB  - In systemic mastocytosis the liver, spleen, and lymph nodes may be infiltrated by mast cells, with patterns of infiltration specific for each tissue. This may result in hepatosplenomegaly and enlarged lymph nodes. Extensive involvement with mast cells may also be associated with organ dysfunction. Specifically, in the case of liver, mast cell infiltration may result in fibrosis, portal hypertension, and abdominal ascites. Clinically significant involvement of the liver, spleen, and lymph nodes appears to be more common in patients with aggressive forms of mastocytosis, including those with a hematologic disorder. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIVER
KW  - LYMPH nodes
KW  - MAST cell disease
KW  - MAST cells
KW  - LYMPHOID tissue
KW  - PATIENTS
N1  - Accession Number: 12469022; Metcalfe, Dean D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p45S; Subject Term: LIVER; Subject Term: LYMPH nodes; Subject Term: MAST cell disease; Subject Term: MAST cells; Subject Term: LYMPHOID tissue; Subject Term: PATIENTS; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469022
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Parker, Robert I.
T1  - Hematologic Aspects of Mastocytosis: I: Bone Marrow Pathology in Adult and Pediatric Systemic Mast Cell Disease.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 47S
EP  - 51S
SN  - 0022202X
AB  - The typical bone marrow lesions seen in adults with systemic mast cell disease (SMCD) are foci of spindle-shaped mast cells in a fibrotic matrix and are found in up to 90% of adults with SMCD. Lymphocytes and eosinophils frequently are admixed with the mast cells, forming the classic MEL lesion. The mast cell lesions can be found in perivascular, peritrabecular, or intertrabecular locations and may on occasion completely replace intratrabecular regions of the marrow. In contrast, the mast cell lesions found in children with cutaneous mast cell disorders are uniformly small and subtle and are most frequently located perivascularly. Lymphocytes, eosinophils, and early myeloid elements may be associated with these lesions. Of perhaps greater specificity for SMCD is the finding of confluent clusters of mast cells on the marrow aspirates; such clusters are noted in up to 30% of patients with SMCD. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BONE marrow
KW  - MAST cells
KW  - PATHOLOGY
KW  - ADULTS
KW  - LYMPHOCYTES
KW  - PATIENTS
N1  - Accession Number: 12469034; Parker, Robert I. 1; Affiliation:  1: Hematology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p47S; Subject Term: BONE marrow; Subject Term: MAST cells; Subject Term: PATHOLOGY; Subject Term: ADULTS; Subject Term: LYMPHOCYTES; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469034
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Parker, Robert I.
T1  - Hematologic Aspects of Mastocytosis: II: Management of Hematologic Disorders in Association with Systemic Mast Cell Disease.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 52S
EP  - 54S
SN  - 0022202X
AB  - Individuals with systemic mast cell disease (SMCD) may develop various hematologic abnormalities, including cytopenias, myeloproliferative or myelodysplastic syndromes, lymphoproliferative syndromes, and primary or secondary leukemias. Management of those patients is often complicated by their associated hematologic abnormalities. In the case of non-malignant hematologic syndromes, the approach to management is supportive. At present, overt malignancies are managed with traditional chemotherapy. The presence of leukemia in patients with mast cell disease usually indicates a grave prognosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEMATOLOGY
KW  - MAST cell disease
KW  - DRUG therapy
KW  - SYNDROMES
KW  - LEUKEMIA
KW  - PATIENTS
N1  - Accession Number: 12469045; Parker, Robert I. 1; Affiliation:  1: Hematology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p52S; Subject Term: HEMATOLOGY; Subject Term: MAST cell disease; Subject Term: DRUG therapy; Subject Term: SYNDROMES; Subject Term: LEUKEMIA; Subject Term: PATIENTS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469045
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12469045&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - The Treatment of Mastocytosis: An Overview.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03//
VL  - 96
IS  - 3
M3  - Article
SP  - 55S
EP  - 59S
SN  - 0022202X
AB  - The treatment of mastocytosis requires a recognition of specific disease patterns of involvement, with consequent institution of appropriate therapy based on the disease pattern manifested in a given patient. Treatment for most forms of mastocytosis is conservative and symptomatic. H1 and H2 antihistamines in combination or alone remain the primary drugs of choice. In specific cases, patients may require aspirin and/or steroids; some must be prepared to self-administer epinephrine for severe anaphylactic episodes. In patients with associated hematologic disorders, the treatment of the disorder will depend on the hematologic findings. In rare cases, and in aggressive forms of mastocytosis only, it may be necessary to consider limited forms of chemotherapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - PATIENTS
KW  - DRUG therapy
KW  - ANTIHISTAMINES
KW  - HEMATOLOGY
KW  - THERAPEUTICS
N1  - Accession Number: 12469049; Metcalfe, Dean D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991, Vol. 96 Issue 3, p55S; Subject Term: MAST cell disease; Subject Term: PATIENTS; Subject Term: DRUG therapy; Subject Term: ANTIHISTAMINES; Subject Term: HEMATOLOGY; Subject Term: THERAPEUTICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469049
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12469049&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Atkinson, Jane C.
AU  - Frank, Michael M.
T1  - Oral manifestations and dental management of patients with hereditary angioedema.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1991/03//
VL  - 20
IS  - 3
M3  - Article
SP  - 139
EP  - 142
SN  - 09042512
AB  - Hereditary angioedema (HAE) is a genetic disorder in which affected individuals develop extensive, spontaneous angioedema of the extremities, gastrointestinal tract, and oropharynx. Dental treatment of unmedicated patients with HAI can trigger life-threatening pharyngeal edema. Previously, it was demonstrated that the administration of fresh frozen plasma (FFP) before surgery prevented angioedema attacks in 6 patients undergoing dental extractions. The present study examines the long term effectiveness of FFP in preventing angioedema from developing in 53 patients with HAE undergoing all types of dental treatment over a ten-year period. Only 3 of 45 patients (6.7&%) covered with FFP had a minor angioedema attack after dental therapy in 10 yr. No attacks of moderate or severe swelling were seen. Attacks occurred independently of the disease activity of the patient and the trauma of the dental procedure. The use of fresh frozen plasma is effective in preventing attacks of angioedema in HAE patients undergoing all types of dental procedures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANGIONEUROTIC edema
KW  - ORAL manifestations of general diseases
KW  - DENTISTRY
KW  - Complement
KW  - Dental treatment
KW  - Hereditary angiooedema
N1  - Accession Number: 11476897; Atkinson, Jane C. 1 Frank, Michael M. 2; Affiliation:  1: Clinical Investigations and Patient Care Branch, National Institute of Dental Research  2: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, USA; Source Info: Mar1991, Vol. 20 Issue 3, p139; Subject Term: ANGIONEUROTIC edema; Subject Term: ORAL manifestations of general diseases; Subject Term: DENTISTRY; Author-Supplied Keyword: Complement; Author-Supplied Keyword: Dental treatment; Author-Supplied Keyword: Hereditary angiooedema; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1600-0714.ep11476897
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11476897&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Engel, Bernard T.
AU  - Talan, Mark I.
T1  - Hemodynamic and Respiratory Concomitants of Learned Heart Rate Control During Exercise.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1991/03//
VL  - 28
IS  - 2
M3  - Article
SP  - 225
EP  - 230
SN  - 00485772
AB  - Each of three monkeys was trained to slow its heart, to exercise (lift weights), and to attenuate the tachycardia of exercise by combining these two skills. During all experiments, heart rate, stroke volume, intra-arterial blood pressure, O[SUB2] consumption, and CO[SUB2] production were recorded on a beat-to-beat basis. All animals reliably attenuated the tachycardia of exercise, indicating that this expression of central command is, at least in part, a learned motor skill. Double-product (heart rate × systolic pressure) was attenuated during combined sessions relative to exercise only sessions, and heart rate was always lower at similar levels of cardiac output, indicating that under the combined conditions, animals were performing with better cardiac efficiency at comparable levels of mechanical effort. Analyses of O[SUB2] consumption, CO[SUB2] production, and respiratory quotient (the ratio of CO[SUB2] production to O[SUB2] consumption) suggested that the animals also might have been delivering more O[SUB2] to their working muscles during combined sessions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OPERANT conditioning
KW  - CONDITIONED response
KW  - HEART beat
KW  - EXERCISE
KW  - HEMODYNAMICS
KW  - RESPIRATION
KW  - Exercise
KW  - Heart rate
KW  - Hemodynamics
KW  - Operant conditioning
KW  - Respiration.
N1  - Accession Number: 11028597; Engel, Bernard T. 1 Talan, Mark I. 1; Affiliation:  1: Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Gerontology Research Center', Baltimore, Maryland.; Source Info: Mar1991, Vol. 28 Issue 2, p225; Subject Term: OPERANT conditioning; Subject Term: CONDITIONED response; Subject Term: HEART beat; Subject Term: EXERCISE; Subject Term: HEMODYNAMICS; Subject Term: RESPIRATION; Author-Supplied Keyword: Exercise; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Hemodynamics; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Respiration.; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kettelhut, Brett V
AU  - Metcalfe, Dean D
T1  - Pediatric Mastocytosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03/02/Mar1991 Supplement
VL  - 96
M3  - Article
SP  - 15
EP  - 18
SN  - 0022202X
AB  - The onset of mastocytosis occurs between birth and 2 years of age in approximately 55% of all cases; an additional 10% develop the disease before the age of 15 years. Mastocytosis in these age groups differs in many respects from mastocytosis that has its onset in adulthood. The typical presentation of pediatric-onset mastocytosis consists of cutaneous manifestations: either a solitary mastocytoma, urticaria pigmentosa, or, less commonly, diffuse cutaneous mastocytosis. Particularly in infants, bullous eruptions may occur. Mastocytosis in infants and children may involve internal organs, including the bone marrow and the gastrointestinal tract, although such manifestations appear to be less common in children than in adults. Plasma histamine levels may be elevated in pediatric- onset mastocytosis. Treatment usually involves the use of H1 and H2 antihistamines to control itching and to control the hypersecretion of gastric acid that may occur. The prognosis for children with mast cell disease is variable; approximately half of the children with urticaria pigmentosa may experience resolution of lesions and symptoms by adolescence.Journal of Investigative Dermatology (1991) 96, 15S–18S; doi:10.1111/1523-1747.ep12468942 [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - IMMUNOLOGIC diseases
KW  - SKIN diseases
KW  - BONE marrow diseases
KW  - URTICARIA
KW  - PEDIATRICS
N1  - Accession Number: 23858117; Kettelhut, Brett V 1 Metcalfe, Dean D 2; Affiliation:  1: 1Division of Allergy and Clinical Immunology , Children's Hospital Medical Center, Elland and Bethesda Avenue, Cincinnati, Ohio, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: 2Mast Cell Physiology Section , Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991 Supplement, Vol. 96, p15; Subject Term: MAST cell disease; Subject Term: IMMUNOLOGIC diseases; Subject Term: SKIN diseases; Subject Term: BONE marrow diseases; Subject Term: URTICARIA; Subject Term: PEDIATRICS; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12468942
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Parker, Robert I.
T1  - Hematologic Aspects of Mastocytosis: II: Management of Hematologic Disorders in Association with Systemic Mast Cell Disease.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03/02/Mar1991 Supplement
VL  - 96
M3  - Article
SP  - 52
EP  - 54
SN  - 0022202X
AB  - Individuals with systemic mast cell disease (SMCD) may develop various hematologic abnormalities, including cytopenias, myeloproliferative or myelodysplastic syndromes, lymphoproliferative syndromes, and primary or secondary leukemias. Management of those patients is often complicated by their associated hematologic abnormalities. In the case of non-malignant hematologic syndromes, the approach to management is supportive. At present, overt malignancies are managed with traditional chemotherapy. The presence of leukemia in patients with mast cell disease usually indicates a grave prognosis.Journal of Investigative Dermatology (1991) 96, 52S–54S; doi:10.1111/1523-1747.ep12469045 [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - BLOOD diseases
KW  - MYELOPROLIFERATIVE disorders
KW  - LYMPHOPROLIFERATIVE disorders
KW  - LEUKEMIA
KW  - DRUG therapy
KW  - PROGNOSIS
N1  - Accession Number: 23858110; Parker, Robert I. 1; Affiliation:  1: Hematology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991 Supplement, Vol. 96, p52; Subject Term: MAST cell disease; Subject Term: BLOOD diseases; Subject Term: MYELOPROLIFERATIVE disorders; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: LEUKEMIA; Subject Term: DRUG therapy; Subject Term: PROGNOSIS; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
L3  - 10.1111/1523-1747.ep12469045
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23858110&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - The Treatment of Mastocytosis: An Overview.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03/02/Mar1991 Supplement
VL  - 96
M3  - Article
SP  - 55
EP  - 59
SN  - 0022202X
AB  - The treatment of mastocytosis requires a recognition of specific disease patterns of involvement, with consequent institution of appropriate therapy based on the disease pattern manifested in a given patient. Treatment for most forms of mastocytosis is conservative and symptomatic. H1 and H2 antihistamines in combination or alone remain the primary drugs of choice. In specific cases, patients may require aspirin and/or steroids; some must be prepared to self-administer epinephrine for severe anaphylactic episodes. In patients with associated hematologic disorders, the treatment of the disorder will depend on the hematologic findings. In rare cases, and in aggressive forms of mastocytosis only, it may be necessary to consider limited forms of chemotherapy.Journal of Investigative Dermatology (1991) 96, 55S–59S; doi:10.1111/1523-1747.ep12469049 [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cell disease
KW  - ANTIHISTAMINES
KW  - ADRENALINE
KW  - SKIN diseases
KW  - ANTICOAGULANTS (Medicine)
KW  - DRUG therapy
N1  - Accession Number: 23858109; Metcalfe, Dean D. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991 Supplement, Vol. 96, p55; Subject Term: MAST cell disease; Subject Term: ANTIHISTAMINES; Subject Term: ADRENALINE; Subject Term: SKIN diseases; Subject Term: ANTICOAGULANTS (Medicine); Subject Term: DRUG therapy; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3  - 10.1111/1523-1747.ep12469049
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23858109&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - General Discussion: Toward a Standard Evaluation for Data Sharing and Prognosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/03/02/Mar1991 Supplement
VL  - 96
M3  - Article
SP  - 60
EP  - 63
SN  - 0022202X
AB  - The article discusses the medical practitioner's prespectives on patients with mastocytosis for the standard evaluation for data sharing and prognosis. Dr. Dean D. Metcalfe said that it gained counseling of patients easier for it relates the clinical picture to prognosis. The challenge is to set up criteria that discriminate patients who have a poor prognosis from those who have a good prognosis so that you can deal with them in a different way.
KW  - DECISION making in clinical medicine
KW  - MAST cell disease
KW  - PROGNOSIS
KW  - DIAGNOSIS
KW  - MEDICAL care
N1  - Accession Number: 23858108; Metcalfe, Dean D. 1; Affiliation:  1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1991 Supplement, Vol. 96, p60; Subject Term: DECISION making in clinical medicine; Subject Term: MAST cell disease; Subject Term: PROGNOSIS; Subject Term: DIAGNOSIS; Subject Term: MEDICAL care; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469487
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Boice Jr., John D.
AU  - Morin, Michele M.
AU  - Glass, Andrew G.
AU  - Friedman, Gary D.
AU  - Stovall, Marilyn
AU  - Hoover, Robert N.
AU  - Fraumeni Jr., Joseph F.
AU  - Evens, Ronald G.
AU  - Boice, J D Jr
AU  - Morin, M M
AU  - Glass, A G
AU  - Friedman, G D
AU  - Stovall, M
AU  - Hoover, R N
AU  - Fraumeni, J F Jr
T1  - Diagnostic x-ray procedures and risk of leukemia, lymphoma, and multiple myeloma.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/03/13/
VL  - 265
IS  - 10
M3  - journal article
SP  - 1290
EP  - 1294
SN  - 00987484
AB  - Exposure to diagnostic x-rays and the risk of leukemia, non-Hodgkin's lymphoma (NHL), and multiple myeloma were studied within two prepaid health plans. Adult patients with leukemia (n = 565), NHL (n = 318), and multiple myeloma (n = 208) were matched to controls (n = 1390), and over 25,000 x-ray procedures were abstracted from medical records. Dose response was evaluated by assigning each x-ray procedure a score based on estimated bone marrow dose. X-ray exposure was not associated with chronic lymphocytic leukemia, one of the few malignant conditions never linked to radiation (relative risk [RR], 0.66). For all other forms of leukemia combined (n = 358), there was a slight elevation in risk (RR, 1.17) but no evidence of a dose-response relationship when x-ray procedures near the time of diagnosis were excluded. Similarly, patients with NHL were exposed to diagnostic x-ray procedures more often than controls (RR, 1.32), but the RR fell to 0.99 when the exposure to diagnostic x-ray procedures within 2 years of diagnosis was ignored. For multiple myeloma, overall risk was not significantly high (RR, 1.14), but there was consistent evidence of increasing risk with increasing numbers of diagnostic x-ray procedures. These data suggest that persons with leukemia and NHL undergo x-ray procedures frequently just prior to diagnosis for conditions related to the development or natural history of their disease. There was little evidence that diagnostic x-ray procedures were causally associated with leukemia or NHL. The risk for multiple myeloma, however, was increased among those patients who were frequently exposed to x-rays. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL radiology
KW  - X-rays
KW  - LEUKEMIA -- Risk factors
KW  - LYMPHOMAS -- Risk factors
KW  - MULTIPLE myeloma
KW  - MEDICAL care
KW  - RISK factors
N1  - Accession Number: 10549847; Boice Jr., John D. Morin, Michele M. Glass, Andrew G. Friedman, Gary D. Stovall, Marilyn Hoover, Robert N. Fraumeni Jr., Joseph F. Evens, Ronald G. Boice, J D Jr 1 Morin, M M Glass, A G Friedman, G D Stovall, M Hoover, R N Fraumeni, J F Jr; Affiliation:  1: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20852; Source Info: 3/13/91, Vol. 265 Issue 10, p1290; Subject Term: MEDICAL radiology; Subject Term: X-rays; Subject Term: LEUKEMIA -- Risk factors; Subject Term: LYMPHOMAS -- Risk factors; Subject Term: MULTIPLE myeloma; Subject Term: MEDICAL care; Subject Term: RISK factors; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Guralnik, Jack M.
AU  - LaCroix, Andrea Z.
AU  - Branch, Laurence G.
AU  - Kasl, Stanislav V.
AU  - Wallace, Robert B.
T1  - Morbidity and Disability in Older Persons in the Years Prior to Death.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/04//
VL  - 81
IS  - 4
M3  - Article
SP  - 443
EP  - 447
PB  - American Public Health Association
SN  - 00900036
AB  - Background: A large proportion of the disease and disability which affects older persons occurs in the years just prior to death. Little prospective evidence is available which quantifies the burden of morbidity and disability during these years. Methods: in three community-based cohorts of persons age 65 and older, chronic conditions and disability were evaluated for the three years prior to death in 531 persons who had three annual assessments and then died within one year of the third assessment. Number of chronic conditions, prevalence of disability in activities of daily living (ADLs), and prevalence of disability on a modified Rosow-Breslau scale were determined for these decedents and compared to 8821 members of the cohorts known to have survived. Results: Prevalence rates of disease and disability increased during the follow-up for both decedents and survivors, with decedents generally having higher rates than survivors. Disability rates prior to death, but not the number of diseases, increased with increasing age at death. The odds ratio for disability in ADLs at any of the three assessments for decedents versus survivors ranged from 3.0 to 4.2 in the three communities. In each community the odds ratio for ADL disability was higher in women decedents versus survivors than in men decedents versus survivors. Conclusions: These results have important implications for disability levels in future older populations in which death is projected to occur at increasingly higher ages. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OLDER people -- Diseases
KW  - DISABILITIES
KW  - DEATH
KW  - HEALTH status indicators
KW  - PROXY
KW  - RESEARCH
KW  - SELF-evaluation
KW  - CHRONIC diseases
KW  - PERIODIC health examinations
KW  - COHORT analysis
KW  - GENDER
N1  - Accession Number: 9104222065; Guralnik, Jack M. 1 LaCroix, Andrea Z. 2 Branch, Laurence G. 3 Kasl, Stanislav V. 4 Wallace, Robert B. 5; Affiliation:  1: Epidemiology, Demography and Biometry Program, National Institute on Aging, 7550 Wisconsin Avenue, Federal Building. ,Bethesda, MD 20842  2: Group Health Cooperative of Puget Sound and the Department of Epidemiology at the University of Washington, Seattle  3: Department of Six;io-Medical Sciences and Community Medicine, Boston University School of Medicine  4: Department of Epidemiology and Public Health, Yale University School of Medicine  5: Department of Preventive Medicine and Environmental Health, University of Iowa; Source Info: Apr91, Vol. 81 Issue 4, p443; Subject Term: OLDER people -- Diseases; Subject Term: DISABILITIES; Subject Term: DEATH; Subject Term: HEALTH status indicators; Subject Term: PROXY; Subject Term: RESEARCH; Subject Term: SELF-evaluation; Subject Term: CHRONIC diseases; Subject Term: PERIODIC health examinations; Subject Term: COHORT analysis; Subject Term: GENDER; Number of Pages: 5p; Illustrations: 2 Charts, 18 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jepson, Christopher
AU  - Kessler, Larry G.
AU  - Portnoy, Barry
AU  - Gibbs, Tyson
T1  - Black-White Differences in Cancer Prevention Knowledge and Behavior.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/04//
VL  - 81
IS  - 4
M3  - Article
SP  - 501
EP  - 504
PB  - American Public Health Association
SN  - 00900036
AB  - Data from the 1987 National Health Interview Survey Cancer Control Supplement were used to estimate multivariate logistic regression models of diet change, mammography utilization, stool blood test utilization, and smoking. Predictor variables included race, sex, age, income, dietary concerns, and four knowledge-related variables: education atid three measures of cancer prevention knowledge. When knowledge variables were included in the models, race was not a significant predictor of behavior, with one exception: among women, Blacks were found to smoke less than Whites. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER prevention
KW  - REGRESSION analysis
KW  - MAMMOGRAMS
KW  - SMOKING
KW  - DIET
KW  - INCOME
KW  - AGE
KW  - HUMAN sexuality
KW  - TOBACCO use
N1  - Accession Number: 9104222081; Jepson, Christopher 1 Kessler, Larry G. 1 Portnoy, Barry 1 Gibbs, Tyson 1; Affiliation:  1: National Cancer Institute, Bethesda, MD; Source Info: Apr91, Vol. 81 Issue 4, p501; Subject Term: CANCER prevention; Subject Term: REGRESSION analysis; Subject Term: MAMMOGRAMS; Subject Term: SMOKING; Subject Term: DIET; Subject Term: INCOME; Subject Term: AGE; Subject Term: HUMAN sexuality; Subject Term: TOBACCO use; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Camera, L.
AU  - Vecchio, S.
AU  - Petrillo, A.
AU  - Esposito, G.
AU  - Frasci, G.
AU  - Iaffaioli, R.
AU  - Bianco, A.
AU  - Salvatore, M.
T1  - Evaluation of therapeutic response using iodine-131-B72.3 monoclonal antibody in patients with ovarian carcinoma.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1991/04//
VL  - 18
IS  - 4
M3  - Article
SP  - 269
EP  - 273
SN  - 03406997
N1  - Accession Number: 71144207; Camera, L. 1 Vecchio, S. 1 Petrillo, A. 1 Esposito, G. 1 Frasci, G. 2 Iaffaioli, R. 3 Bianco, A. 2 Salvatore, M. 1; Affiliation:  1: Nuclear Medicine Department, National Cancer Institute, and Institute of Nuclear Medicine, II School of Medicine, Naples Italy  2: Oncology Division, II School of Medicine, Naples Italy  3: Oncology Division, University of Cagliari, Italy; Source Info: Apr1991, Vol. 18 Issue 4, p269; Number of Pages: 5p; Document Type: Article
L3  - 10.1007/BF00186652
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=71144207&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hohl, Daniel
AU  - Lichti, Ulrike
AU  - Breitkreutz, Dirk
AU  - Steinert, Peter M.
AU  - Roop, Dennis R.
T1  - Transcription of the Human Loricrin Gene In Vitro Is Induced by Calcium and Cell Density and Suppressed by Retinoic Acid.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/04//
VL  - 96
IS  - 4
M3  - Article
SP  - 414
EP  - 418
SN  - 0022202X
AB  - We have previously shown that loricrin is a major component of the cornified cell envelope (CE) expressed late in epidermal differentiation in the granular layers of normal skin. Normal human keratinocytes were cultured under various conditions and loricrin mRNA levels were assessed at various time points. Only Ca++ concentrations above 0.1 mM Ca++ were permissive for the expression of loricrin mRNA. Maximal mRNA levels were found at 0.35 mM Ca++ and a critical cell density appeared to be required for optimal accumulation of lonicrin transcripts. Retinoic acid (RA) at 10-7 to 10-9 M completely blocked Ca++ tinduced loricrin mRNA synthesis when applied simultaneously. Furthermore, addition of RA to cultures already exposed to higher Ca++ levels resulted in the complete loss of loricrin mRNA within 48-72 h. So far, no other components of the CE have been shown to be suppressed by RA. However, similar patterns of expression were reported for filaggrin, a matrix protein also expressed late in epidermal differentiation. Therefore, we compared the mRNA levels of loricrin and filaggrin and found them to change in parallel in response to the various culture conditions. These results suggest that Ca++, cell density, and RA are crucial regulators of loricrin expression in vitro and that the transcriptional control of loricrin and filaggrin expression in the epidermis are closely coordinated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MESSENGER RNA
KW  - KERATINOCYTES
KW  - TRETINOIN
KW  - EXTRACELLULAR matrix proteins
KW  - SKIN
KW  - EPIDERMIS
N1  - Accession Number: 12469779; Hohl, Daniel 1,2,3,4 Lichti, Ulrike 3 Breitkreutz, Dirk 5 Steinert, Peter M. 2,6 Roop, Dennis R. 3,4; Affiliation:  1: Dermatology, University Hospital of Zurich, Zurich, Switzerland.  2: Dermatology Branch, Laboratory of Skin Biology, Bethesda, Maryland.  3: LCCTP, NCI, National Institutes of Health, Bethesda, Maryland.  4: Departments of Cell Biology and Dermatology, Baylor College of Medicine, Houston, Texas, U.S,A.  5: Division of Differentiation and Carcinogenesis In Vitro, Institute of Biochemistry, German Cancer Research Center, Heidelberg, Germany.  6: NIAMS, NCI, National Institutes of Health, Bethesda, Maryland.; Source Info: Apr91, Vol. 96 Issue 4, p414; Subject Term: MESSENGER RNA; Subject Term: KERATINOCYTES; Subject Term: TRETINOIN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: SKIN; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12469779
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12469779&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Piedmont, Ralph L.
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Adjective Check List Scales and the Five-Factor Model.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1991/04//
VL  - 60
IS  - 4
M3  - Article
SP  - 630
EP  - 637
SN  - 00223514
AB  - Correlations of Adjective Check List (ACL; Gough & Heilbrun, 1965,1983) scales with measures of the five-factor model of personality provide a basis for reinterpreting earlier studies and construing new ACL scales in terms of a common conceptual framework. In Study 1, 414 undergraduate students (264 women, 150 men) completed the ACL, and scales were factored together with John's (1990) ACL markers of the five factors. In Study 2,445 (198 women, 247 men) adult volunteers from the Augmented Baltimore Longitudinal Study of Aging completed the ACL. Self-report, spouse, and peer ratings on the NEO Personality Inventory, which measures the five factors, were available for subsets of these Ss. When appropriate markers are used, the five factors can be recovered from the ACL, although most ACL scales are themselves multifactorial. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADJECTIVE Check List
KW  - PERSONALITY tests
KW  - SCALE analysis (Psychology)
KW  - SELF-evaluation
KW  - NEO Personality Inventory
N1  - Accession Number: 9104222453; Piedmont, Ralph L. 1 McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation:  1: Gerontology Research Center National Institute on Aging, National Institutes of Health Baltimore, Maryland; Source Info: Apr91, Vol. 60 Issue 4, p630; Subject Term: ADJECTIVE Check List; Subject Term: PERSONALITY tests; Subject Term: SCALE analysis (Psychology); Subject Term: SELF-evaluation; Subject Term: NEO Personality Inventory; Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ketterlinus, Robert D.
AU  - Henderson, Sandra
AU  - Lamb, Michael E.
T1  - The Effects of Maternal Age-at-Birth on Children's Cognitive Development.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1991/04//
VL  - 1
IS  - 2
M3  - Article
SP  - 173
EP  - 188
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - Compares the school achievement scores of elementary-school children born to either adolescent or adult mothers using data obtained from a nationally representative sample of contemporary youth and their children.  Effects of maternal age on children's school achievement; Need to reexamine conclusions about the effects of adolescent motherhood on children's cognitive development.
KW  - MATERNAL age
KW  - TEENAGE mothers
KW  - COGNITIVE development
KW  - CHILD development
N1  - Accession Number: 11298324; Ketterlinus, Robert D. 1 Henderson, Sandra 1 Lamb, Michael E. 1; Affiliation:  1: National Institute of Child Health and Human Development; Source Info: 1991, Vol. 1 Issue 2, p173; Subject Term: MATERNAL age; Subject Term: TEENAGE mothers; Subject Term: COGNITIVE development; Subject Term: CHILD development; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104748574
T1  - Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial.
AU  - Max, M B
AU  - Kishore-Kumar, R
AU  - Schafer, S C
AU  - Meister, B
AU  - Gracely, R H
AU  - Smoller, B
AU  - Dubner, R
Y1  - 1991/04//1991 Apr
N1  - Accession Number: 104748574. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Desipramine -- Therapeutic Use
KW  - Diabetic Neuropathies -- Drug Therapy
KW  - Pain -- Drug Therapy
KW  - Adult
KW  - Aged
KW  - Benztropine -- Therapeutic Use
KW  - Depression -- Complications
KW  - Desipramine -- Adverse Effects
KW  - Diabetic Neuropathies -- Complications
KW  - Double-Blind Studies
KW  - Emotions -- Drug Effects
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Pain -- Etiology
SP  - 3
EP  - 2
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 45
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1861872.
DO  - 10.1016/0304-3959(91)90157-S
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104748574&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104748580
T1  - Thermographic observations on rats with experimental neuropathic pain.
AU  - Bennett, G J
AU  - Ochoa, J L
Y1  - 1991/04//1991 Apr
N1  - Accession Number: 104748580. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Body Temperature Regulation
KW  - Nervous System -- Physiopathology
KW  - Pain -- Physiopathology
KW  - Reflex Sympathetic Dystrophy -- Physiopathology
KW  - Animals
KW  - Cold
KW  - Male
KW  - Rats
KW  - Skin Temperature -- Physiology
KW  - Thermography
KW  - Sulfur Compounds -- Pharmacodynamics
SP  - 61
EP  - 67
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 45
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1861879.
DO  - 10.1016/0304-3959(91)90165-T
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104748580&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2014-04080-001
AN  - 2014-04080-001
AU  - Arons, Bernard S.
T1  - Review of Psychiatric medications: A guide for mental health professionals.
JF  - Psychosocial Rehabilitation Journal
JO  - Psychosocial Rehabilitation Journal
Y1  - 1991/04//
VL  - 14
IS  - 4
SP  - 97
EP  - 98
CY  - US
PB  - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN  - 0147-5622
N1  - Accession Number: 2014-04080-001. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Arons, Bernard S.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Therapy. Minor Descriptor: Mental Disorders; Mental Health Personnel; Psychosocial Rehabilitation. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Bender, Kenneth J. Psychiatric medications: A guide for mental health professionals=Newbury Park, CA: Sage Publications, Inc., 143 pages, $14.00; 1990. Page Count: 2. Issue Publication Date: Apr, 1991. 
AB  - Reviews the book, Psychiatric Medications: A Guide for Mental Health Professionals by Kenneth J. Bender (see record [rid]1990-98031-000[/rid]). There are many issues and questions that arise concerning medication and people with mental illness in psychosocial rehabilitation programs. Sometimes staff members, family members, friends, and consumers are fortunate enough to have the psychiatrist take the time to answer their questions and give advice. Sometimes, a consultant is available who, although not the primary psychiatrist for the individual, is willing to take the time to answer questions. Most often, however, there is no adequate source of advice, help, or information. Author fills this gap in his book. The author discusses the integration of medication use in a comprehensive approach to individuals and the use of referrals to psychiatrists. The book is complete with appropriate references, a complete subject index, and a very useful medication index for immediate reference to the discussion in the book of specific medications. Mental health workers in a variety of rehabilitation centers will find this a most helpful handbook. Those without extensive knowledge or background in medications will turn to it frequently for a good overview of the medications their clients are given and some of the consequences of their use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychiatric medications
KW  - mental illness
KW  - psychosocial rehabilitation
KW  - mental health professionals
KW  - 1991
KW  - Drug Therapy
KW  - Mental Disorders
KW  - Mental Health Personnel
KW  - Psychosocial Rehabilitation
KW  - 1991
U2  - Bender, Kenneth J. (1990); Psychiatric medications: A guide for mental health professionals; Newbury Park, CA: Sage Publications, Inc., 143 pages, $14.00
DO  - 10.1037/h0099404
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-04080-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - GEN
AU  - Lane, H. Clifford
AU  - Holmberg, Scott D.
AU  - Jaffe, Harold W.
T1  - HIV Seroconversion and Oral Intercourse.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/05//
VL  - 81
IS  - 5
M3  - Letter
SP  - 658
EP  - 658
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "HIV seroconversion in two homosexual men after receptive oral intercourse with ejaculation: Implications for counseling concerning safe sexual practices," by A. R. Lifson and colleagues, which appeared in a 1990 issue of the periodical.
KW  - LETTERS to the editor
KW  - ORAL sex
N1  - Accession Number: 19878451; Lane, H. Clifford 1 Holmberg, Scott D. 2 Jaffe, Harold W. 2; Affiliation:  1: National Institute of Allergy and Infectious Diseases, Building 10, Room 11B09, National Institutes of Health, Bethesda, MD 20892  2: Division of HIV/AIDS, Mailstop E45, Center for Infectious Diseases, Centers for Disease Control, 1600 Clifton Rd, Atlanta, GA 30333; Source Info: May91, Vol. 81 Issue 5, p658; Subject Term: LETTERS to the editor; Subject Term: ORAL sex; Number of Pages: 5/6p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
T1  - Culture Control and Commitment: A Study of Work Organizations in America (Book).
JO  - American Journal of Sociology
JF  - American Journal of Sociology
Y1  - 1991/05//
VL  - 96
IS  - 6
M3  - Book Review
SP  - 1600
SN  - 00029602
AB  - Reviews the book "Culture, Control, and Commitment: A Study of Work Organization and Work Attitudes in the United States and Japan," by James R. Lincoln and Arne L. Kalleberg.
KW  - ORGANIZATIONAL behavior
KW  - NONFICTION
KW  - LINCOLN, James R.
KW  - KALLEBERG, Arne L.
KW  - CULTURE, Control & Commitment: A Study of Work Organization & Work Attitudes in the United States & Japan (Book)
N1  - Accession Number: 9106172002; Schooler, Carmi 1; Affiliation:  1: National Institute of Mental Health; Source Info: May91, Vol. 96 Issue 6, p1600; Subject Term: ORGANIZATIONAL behavior; Subject Term: NONFICTION; Reviews & Products: CULTURE, Control & Commitment: A Study of Work Organization & Work Attitudes in the United States & Japan (Book); People: LINCOLN, James R.; People: KALLEBERG, Arne L.; Number of Pages: 3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pharis, Mary E.
AU  - Levin, Victoria S.
T1  - "A Person To Talk to Who Really Cared": High-Risk Mothers' Evaluations of Services in an Intensive Intervention Research Program. (Cover story)
JO  - Child Welfare
JF  - Child Welfare
Y1  - 1991/05//May/Jun91
VL  - 70
IS  - 3
M3  - Article
SP  - 307
EP  - 320
PB  - Child Welfare League of America
SN  - 00094021
AB  - The article cites a study which focused on 30 women in the U.S. at high risk for parenting disorders. The women were provided with intensive intervention services as part of the study. The study was called the Clinical Infant Development Program and was conducted by the U.S. National Institute of Mental Health's Mental Health Study Center. Pregnant women over the age of 18 were selected for the purpose of the study. Forty-seven high-risk mothers were selected initially for the study. However, only 30 of them completed the study. A structured interview format was utilized for the purpose of the study.
KW  - PARENTING
KW  - FAMILY research
KW  - INTERVENTION (Social services)
KW  - PSYCHIATRIC research
KW  - MOTHERS -- United States
KW  - MENTAL health
KW  - MOTHERHOOD
KW  - UNITED States
KW  - NATIONAL Institute of Mental Health (U.S.)
N1  - Accession Number: 9105270247; Pharis, Mary E. 1 Levin, Victoria S. 2; Affiliation:  1: Associate Professor, School of Social Work, Adjunct Associate Professor, Department of Psychology, and Willoughby Centennial Fellow in Child Welfare. University of Texas at Austin, Austin, TX  2: Executive Secretary, Child and Family Subcommittee. Prevention and Life Course Research Review Committee. Division of Extramural Affairs, National Institute of Mental Health, Rockville, MD; Source Info: May/Jun91, Vol. 70 Issue 3, p307; Subject Term: PARENTING; Subject Term: FAMILY research; Subject Term: INTERVENTION (Social services); Subject Term: PSYCHIATRIC research; Subject Term: MOTHERS -- United States; Subject Term: MENTAL health; Subject Term: MOTHERHOOD; Subject Term: UNITED States; Company/Entity: NATIONAL Institute of Mental Health (U.S.); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 5371
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metzger, H.
T1  - The high affinity receptor for IgE on mast cells.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1991/05//
VL  - 21
IS  - 3
M3  - Article
SP  - 269
EP  - 279
PB  - Wiley-Blackwell
SN  - 09547894
AB  - The purpose of this article is to summarize the current knowledge about high affinity cell receptor for immunoglobulin E on mast cells and how it functions; to describe experimental approaches being used to expand that knowledge; and to assess how such knowledge might be used to develop new approaches for treating allergic reactions. Several reviews in the past have covered various aspects of this subject, so this article will concentrate on the newer data and experimental approaches, according to the author. It is only in hindsight that the importance of the receptor for immunoglobulin E can be seen to have been implied by the seminal observations of several researchers 80 years ago.
KW  - CELL receptors
KW  - ALLERGY
KW  - IMMUNOGLOBULIN E
KW  - MAST cells -- Immunology
KW  - BINDING sites (Biochemistry)
KW  - IMMUNOLOGIC diseases
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 16278626; Metzger, H. 1; Affiliation:  1: Section on Chemical Immunology, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: May1991, Vol. 21 Issue 3, p269; Subject Term: CELL receptors; Subject Term: ALLERGY; Subject Term: IMMUNOGLOBULIN E; Subject Term: MAST cells -- Immunology; Subject Term: BINDING sites (Biochemistry); Subject Term: IMMUNOLOGIC diseases; Subject Term: IMMUNOGLOBULINS; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Hodes, L
AU  - Feldman, A
T1  - Clustering a large number of compounds. Part 3. The limits of classification
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1991/05//
VL  - 31
IS  - 2
M3  - Article
SP  - 347
EP  - 350
SN  - 00952338
AB  - Clustering is normally used to group items that are similar. In this application of obtaining a diverse sample from the 230,000 compounds in the National Cancer Institute Repository, the authors cluster to select compounds that are different from the rest, to optimize screening for new leads. With these constraints, the approach yielded many singleton clusters. One can interpret these results as evidence for a limit to classification, contrary to the customary view of chemistry as a study of classes of compounds.
KW  - CHEMISTRY
KW  - CLASSIFICATION
KW  - CLUSTER analysis
KW  - Chemical data
N1  - Accession Number: ISTA2603197; Hodes, L 1; Feldman, A; Affiliations: 1 : National Institutes of Health, Bethesda, MD;  Source Info: May 1991, Vol. 31 Issue 2, p347; Note: Update Code: 2600; Subject Term: CHEMISTRY; Subject Term: CLASSIFICATION; Subject Term: CLUSTER analysis; Author-Supplied Keyword: Chemical data; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Moshell, Alan N.
AU  - Price, Vera H.
AU  - Headington, John T.
AU  - Bystryn, Jean-Claude
T1  - Introduction.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/05//
VL  - 96
IS  - 5
M3  - Article
SP  - 67S
EP  - 67S
SN  - 0022202X
AB  - This article presents information on a research workshop sponsored by the National Institute of Arthritis and Musculosketeal and Skin Diseases and the National Alopecia Areata Foundation on alopecia areata, a common hair follicle disease. This landmark workshop was held during October 25-26, 1990 in Lister Hill auditorium at the National Institutes of Health, Bethesda, Maryland. It brought together basic and clinical scientists from dermatology, immunology, pathology, biology, biochemistry, pharmacology, genetics and anatomy.
KW  - SEMINARS
KW  - HAIR follicles -- Diseases
KW  - ALOPECIA areata
KW  - BETHESDA (Md.)
KW  - MARYLAND
KW  - UNITED States
N1  - Accession Number: 12471862; Moshell, Alan N. 1 Price, Vera H. 2 Headington, John T. 2 Bystryn, Jean-Claude 2; Affiliation:  1: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland.  2: National Alopecia Areata Foundation, San Rafael, California U.S.A.; Source Info: May91, Vol. 96 Issue 5, p67S; Subject Term: SEMINARS; Subject Term: HAIR follicles -- Diseases; Subject Term: ALOPECIA areata; Subject Term: BETHESDA (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; Number of Pages: 1p; Document Type: Article
L3  - 10.1111/1523-1747.ep12471862
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12471862&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Leonard, Edward J.
AU  - Yoshimura, Teizo
AU  - Tanaka, Shuji
AU  - Raffeld, Mark
T1  - Neutrophil Recruitment by Intradermally Injected Neutrophil Attractant/Activation Protein-1.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/05//
VL  - 96
IS  - 5
M3  - Article
SP  - 690
EP  - 694
SN  - 0022202X
AB  - Neutrophil attractant/activation protein-1 (NAP-l) is a recently described cytokine that attracts neutrophils, but not monocytes or eosinophils. This leukocyte specificity is not absolute, in that NAP-1 attracts basophils and small numbers of lymphocytes. Our purpose was to determine in vivo effects of NAP-1, and to compare them to the reported action of the complement attractant, C5a. Intradermal injection into normal human subjects of 40 μ1 of NAP-l, over a concentration range of 4 × 10-8 M to10-6 M, caused no symptoms or signs such as wheal-and-flare, itching, induration, or tenderness. However, biopsies of injection sites showed perivascular neutrophil infiltration as early as 30 rain, which increased at 1 and 3 h. The mean number of neutrophils per mm² of dermis for 15 biopsies taken 3 h after intradermal injection of 2 × 10-7 M or 100-6 M NAP-1 was 164 ± 41; the response to saline or a NAP-1 inactive fragment was 5 or less. Intradermal NAP-1 did not cause basophil or lymphocyte infiltration. Consistent with the absence of a wheal-and-flare, acid toluidine blue-stained sections showed no evidence of mast cell degranulation, in contrast to previously reported results with C5a. Thus, the predominant response by human subjects to intradermal NAP-1 was neutrophil accumulation in proximity to dermal blood vessels. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEUTROPHILS
KW  - PROTEINS
KW  - CYTOKINES
KW  - LYMPHOCYTES
KW  - BIOPSY
KW  - SYMPTOMS
N1  - Accession Number: 12470612; Leonard, Edward J. 1 Yoshimura, Teizo 1 Tanaka, Shuji 2 Raffeld, Mark 3; Affiliation:  1: Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland.  2: Chemistry Section, Laboratory of Cell Biology, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A.  3: Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May91, Vol. 96 Issue 5, p690; Subject Term: NEUTROPHILS; Subject Term: PROTEINS; Subject Term: CYTOKINES; Subject Term: LYMPHOCYTES; Subject Term: BIOPSY; Subject Term: SYMPTOMS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12470612
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12470612&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lichti, UIrike
AU  - Weinberg, Wendy C.
AU  - Yuspa, Stuart H.
T1  - Properties of Murine Pelage Hair Follicles in Monolayer and Collagen Matrix Cultures.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/05//
VL  - 96
IS  - 5
M3  - Article
SP  - 81S
EP  - 82S
SN  - 0022202X
AB  - This article discusses a technique for isolating mouse pelage hair-follicle preparations that differ in their potential to form hair in nude mouse grafts. Major aims of hair follicle (HF) research include the elucidation of signals that control the initiation and duration of the hair-cycle phases as well as signals that control differentiation of HF matrix cells to form the various layers of the inner root sheath and of the hair itself. The challenge to the cell biologist is the creation at in vitro environment in which the relevant cells continue to perform their in vivo function and can be manipulated in a conotrollable manner.
KW  - HAIR follicles
KW  - EPITHELIUM
KW  - HAIR cells
KW  - COLLAGEN
KW  - CELL culture
KW  - CELLULAR growth
KW  - MICE as laboratory animals
N1  - Accession Number: 12472042; Lichti, UIrike 1 Weinberg, Wendy C. 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Etiology National Cancer Institute, National Institutes of Health, Bethesda Maryland, U.S.A.; Source Info: May91, Vol. 96 Issue 5, p81S; Subject Term: HAIR follicles; Subject Term: EPITHELIUM; Subject Term: HAIR cells; Subject Term: COLLAGEN; Subject Term: CELL culture; Subject Term: CELLULAR growth; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12472042
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12472042&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hatfield, D. L.
AU  - Lee, B. J.
AU  - Price, N. M.
AU  - Stadtman, T. C.
T1  - Selenocysteyl-tRNA occurs in the diatom Thalassiosira and in the ciliate Tetrahymena.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/05//
VL  - 5
IS  - 5
M3  - Article
SP  - 1183
EP  - 1186
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Selenocysteyl-tRNAs that decode UGA were identified previously in animal and bacterial cells and the genes for these tRNAs have been shown to be widespread in animals and eubacteria. In the present study, we identify a selenocysteyl-tRNA that codes for UGA in Thalassiosira pseudonana, which is a diatom, and in Tetrahymena borealis, which is a ciliate. The fact that these very diverse unicellular organisms also contain a selenocysteyl-tRNA suggests that selenocysteine-containing proteins and the use of UGA as a codon for selenocysteine are widespread, if not ubiquitous, in nature. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Diatoms
KW  - Ciliata
KW  - Transfer RNA
KW  - Cells
KW  - Thalassiosira
KW  - Tetrahymena
N1  - Accession Number: 17349385; Hatfield, D. L. 1; Lee, B. J. 1; Price, N. M. 2; Stadtman, T. C. 3; Affiliations: 1: Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Ralph M. Parsons Laboratory, Department of Civil Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; 3: Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: May1991, Vol. 5 Issue 5, p1183; Thesaurus Term: Diatoms; Thesaurus Term: Ciliata; Subject Term: Transfer RNA; Subject Term: Cells; Subject Term: Thalassiosira; Subject Term: Tetrahymena; Number of Pages: 4p; Illustrations: 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Scheffers, Marten K.
AU  - Johnson Jr., Ray
AU  - Ruchkin, Daniel S.
T1  - P300 in Patients with Unilateral Temporal Lobectomies: The Effects of Reduced Stimulus Quality.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1991/05//
VL  - 28
IS  - 3
M3  - Article
SP  - 274
EP  - 284
SN  - 00485772
AB  - The effects of stimulus quality on the amplitude, peak latency, onset latency, and duration of the P300 component of the event-related brain potential were studied in patients with either left or a right anterior temporal lobectomy and in normal controls. Stimulus quality was reduced by adding "noise" letters to words which signaled either a left or a right hand button press. Consistent with an interpretation that stimulus quality affects the subject's degree of equivocation, P300 peak latency, reaction time, and errors were all inversely related to stimulus quality, whereas P300 amplitude was directly related to stimulus quality. There were no significant differences between normal controls and either patient group for any of the Event Related Potential parameters or reaction time. Right temporal lobectomy patients made, however, significantly more errors, particularly on the catch trials, which suggest that they did not process the stimuli as thoroughly and accurately as the subjects in the other two groups. The absence of significant group differences In either the lateral symmetry or overall P300 amplitude extends the evidence against the idea that anterior temporal lobe structures make any substantial contribution to the scalp P300 in a visual discrimination paradigm. Because of observed delays in the onset of P300 in the low-quality stimulus condition, procedures were developed to quantify both P300 onset latency and P300 duration. Reduced stimulus quality significantly increased P300 onset latency whereas P300 duration remained unaffected. indicating that stimulus categorization must occur prior to, and not during, P300. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TEMPORAL lobectomy
KW  - BEHAVIORAL assessment
KW  - COGNITIVE Abilities Test
KW  - EVOKED potentials (Electrophysiology)
KW  - STIMULUS intensity
KW  - TIME perception
KW  - equivocation
KW  - neural generators
KW  - p300
KW  - p300 onset and duration
KW  - temporal lobectomy patients
N1  - Accession Number: 11030730; Scheffers, Marten K. 1 Johnson Jr., Ray 1 Ruchkin, Daniel S. 2; Affiliation:  1: Cognitive Neuroscience Section, Medical Neurology Branch, National Institute of Neuorological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland.  2: Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland.; Source Info: May1991, Vol. 28 Issue 3, p274; Subject Term: TEMPORAL lobectomy; Subject Term: BEHAVIORAL assessment; Subject Term: COGNITIVE Abilities Test; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: STIMULUS intensity; Subject Term: TIME perception; Author-Supplied Keyword: equivocation; Author-Supplied Keyword: neural generators; Author-Supplied Keyword: p300; Author-Supplied Keyword: p300 onset and duration; Author-Supplied Keyword: temporal lobectomy patients; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1469-8986.ep11030730
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11030730&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ruchkin, Daniel S.
AU  - Johnson Jr., Ray
T1  - Complexities Related to Cognitive Slow Wave Experiments: A Reply to Rösler and Heil.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1991/05//
VL  - 28
IS  - 3
M3  - Article
SP  - 359
EP  - 362
SN  - 00485772
AB  - Rösier and Heil (1991) were unable to replicate one of the results of our previous study of slow wave activity and mental arithmetic (Ruchkin, Johnson, Mahaffey, & Sutton, 1988). Thorough examination of the error rates indicates that the greater complexity of their response selection procedure caused crucial differences between how the task was performed in the two studies. Thus Rosler and Heil study emphasizes the need to avoid using a response that is so complex that it produces a superfluous task that obscures the results. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SLOW wave sleep
KW  - MENTAL arithmetic
KW  - COMBINATORIAL analysis
KW  - RESPONSE set
KW  - TECHNOLOGICAL complexity
KW  - SET (Psychology)
KW  - event-related potential
KW  - feedback anticipation
KW  - information processing
KW  - mental arithmetic
KW  - slow wave
KW  - stimulus preceding negativity
N1  - Accession Number: 11030789; Ruchkin, Daniel S. 1 Johnson Jr., Ray 2; Affiliation:  1: University of Maryland School of Medicine, Baltimore, Maryland.  2: National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.; Source Info: May1991, Vol. 28 Issue 3, p359; Subject Term: SLOW wave sleep; Subject Term: MENTAL arithmetic; Subject Term: COMBINATORIAL analysis; Subject Term: RESPONSE set; Subject Term: TECHNOLOGICAL complexity; Subject Term: SET (Psychology); Author-Supplied Keyword: event-related potential; Author-Supplied Keyword: feedback anticipation; Author-Supplied Keyword: information processing; Author-Supplied Keyword: mental arithmetic; Author-Supplied Keyword: slow wave; Author-Supplied Keyword: stimulus preceding negativity; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1469-8986.ep11030789
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11030789&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
T1  - Immune mechanisms in food allergy.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1991/05/02/May1991 Supplement 1
VL  - 21
M3  - Article
SP  - 321
EP  - 324
PB  - Wiley-Blackwell
SN  - 09547894
AB  - Investigates the mechanisms in food allergy. Implications of immune complex and delayed hypersensitivity mechanisms for food hypersensitivity reactions; Need for a combination of dietary avoidance and treatment of inadvertent exposure for the treatment of immediate reactions to food; Role of food hypersensitivity reactions in the genesis of food protein induced enterocolitic syndromes.
KW  - FOOD allergy
KW  - ALLERGY
KW  - FOOD
KW  - IMMUNOLOGIC diseases
KW  - CLINICAL immunology
KW  - IMMUNOLOGY
N1  - Accession Number: 16266454; Metcalfe, Dean D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland 20892; Source Info: May1991 Supplement 1, Vol. 21, p321; Subject Term: FOOD allergy; Subject Term: ALLERGY; Subject Term: FOOD; Subject Term: IMMUNOLOGIC diseases; Subject Term: CLINICAL immunology; Subject Term: IMMUNOLOGY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Foy, J. S.;
AU  - Eastman, R. C.;
AU  - Nealon, R. C.;
AU  - Bowen, P. E.;
AU  - Pucino, F.;
AU  - \ET/;
T1  - Automated therapeutic drug monitoring in an ambulatory care endocrine clinic
CT  - Automated therapeutic drug monitoring in an ambulatory care endocrine clinic
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1991/06/01/
VL  - 48
IS  - Jun
SP  - P
EP  - D
AD  - Pharmacy Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 28-07176; Language: English; Chemical Name: Insulin--9004-10-8 Levothyroxine--51-48-9; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature; Institutional Pharmacy Practice
N2  - An automated therapeutic drug monitoring computer system for assessing endocrine clinical patients prescribed insulin or levothyroxine was developed and implemented. A computer system was designed to retrieve clinical data from the Medical Information Systems (MIS), a hospital-wide computer system, and import this information directly into a Macintosh PC. Prescription entry of either insulin or levothyroxine into MIS activated a computer program to retrieve diagnostic and prescription information, demographics, and laboratory analyses (blood glucose and glycosylated hemoglobin for insulin orders; free thyroxine and thyroid stimulating hormone for levothyroxine orders) on a daily basis. The information was directly received onto the PC and imported into a database program (4th Dimension). The system was capable of identifying laboratory values outside of predetermined therapeutic ranges, maintained an up-to-date patient profile, and offered flexibility in editing and generating reports. Automated therapeutic drug monitoring minimized the time required to collect clinical data. The computer system also alerted clinicians to potential problems and provided a means for assessing overall therapeutic management. Methodology produced and employed in this research can be utilized for evaluating other medications in a variety of general or specialty clinics.
KW  - Insulin--monitoring-;
KW  - Levothyroxine--monitoring-;
KW  - Practice Interest Areas--Computer Systems--meeting presentations;
KW  - ASHP meeting abstracts--computerized therapeutic monitoring;
KW  - Computers--programs--insulin, levothyroxine monitoring;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeLeo, J. M.;
AU  - Calis, K. A.;
AU  - Dorworth, T. E.;
AU  - Pucino, F.;
T1  - Portable patient-entry medication history computer system
CT  - Portable patient-entry medication history computer system
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1991/06/01/
VL  - 48
IS  - Jun
SP  - P
EP  - D
AD  - National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 28-07198; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature; Institutional Pharmacy Practice
N2  - The purpose of this project is to produce a portable patient-entry computerized medication history interviewing and reporting system that models the skills of experienced clinical pharmacists who perform these tasks. A detailed model of an in-depth medication history interview was developed. This model provided the structure for writing a comprehensive lay-language interview script composed of the following sections: 1) demographics, 2) medical conditions, 3) medication regimen, 4) medication compliance, 5) adverse drug-related symptomatology, 6) allergy history, 7) dietary history, 8) psychosocial history, 9) occupational/environmental toxic exposure and 10) patient evaluation of the interview. A special computer language was designed to simplify computer implementation of the interview script. An interpretative program that conducts the interview by processing the computerized version of the script was developed and implemented in Microsoft QuickBASIC. This program was designed to run in an IBM PC or similar microprocessor environment so that interviews may be conducted virtually anywhere with portable laptop computers. A portable, patient-entry, computerized medication history interviewing and reporting system that models expert clinical interviewing and reporting skills is now operational. Interview scripts are easily written, edited and installed. Patients find the system easy to use and need only 30 minutes or less to complete the interview. The system produces a useful comprehensive summary report. The patient-entry medication history system retrieves important clinical information with little time required of clinicians. The portable feature allows for interviews to be conducted virtually anywhere. Early experience with the system suggests potential benefit for improving the quality of patient care.
KW  - Practice Interest Areas--Computer Systems--meeting presentations;
KW  - ASHP meeting abstracts--computerized patient history systems;
KW  - Computers--programs--patient histories;
KW  - Patient information--drug histories--computer programs;
KW  - Interviews--patients--histories, computer programs;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeLeo, J. M.;
AU  - Pucino, F.;
AU  - Calis, K. A.;
T1  - Computer-learned adverse drug reaction detection
CT  - Computer-learned adverse drug reaction detection
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1991/06/01/
VL  - 48
IS  - Jun
SP  - CR
EP  - -3
AD  - National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 28-07177; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature; Adverse Drug Reactions
N2  - The design and development of a computer-learning method which classified the probability of adverse drug reactions using information obtained directly from patients through computer-conducted interviewing is described. Methods employed include: designing an appropriate model to simulate the behavior of clinicians when they gather evidence for detecting adverse drug reactions; using this model to produce a set of one hundred hypothetical patient cases through computer simulation; surveying a panel of seven clinical pharmacist experts for their assessment of adverse drug reaction probability in each of the hypothetical cases; and applying computer-learning methods to emulate the decision-making processes of the clinical pharmacy experts in assessing the probability of adverse drug reactions. Each hypothetical case represents the responses of an individual patient to a computer conducted interview designed to query for the presence of adverse drug reactions. Information collected includes subjective association, temporal sequence (challenge, dechallenge, rechallenge), objective evidence, and alternative etiologies. Hypothetical literature-derived cross-sensitivity information and adverse drug reac ion prevalence data are also incorporated in each case. A computer-learned algorithm that categorized adverse effects probability was produced using the survey data. The algorithm emulates the decision-making processes of the collective panel of experts in categorizing the probability of adverse drug reactions. This work supports the notion that a computer can be trained to model the decision making skills of expert clinical pharmacists in assessing the probability of the presence of adverse drug reactions using information obtained form patient interviewing. It is intended to test and validate the computer-learned model developed here with real clinical cases by comparing the results of the model with the results of expert clinical pharmacists.
KW  - Practice Interest Areas--Computer Systems--meeting presentations;
KW  - ASHP meeting abstracts--adverse reactions computer programs;
KW  - Methodology--drugs, adverse reactions--predictions, computers;
KW  - Computers--programs--adverse reactions;
KW  - Drugs, adverse reactions--computers--predictions;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Baltz, J. K.;
T1  - Current therapy of lung cancer
CT  - Current therapy of lung cancer
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1991/06/01/
VL  - 48
IS  - Jun
SP  - PI
EP  - 34
AD  - National Cancer Institute-Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, MD 20889-5105, USA
N1  - Accession Number: 28-07103; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2  - Lung cancer is the major cause of death due to malignant neoplasms in men and women. In 1989 lung cancer accounted for approximately 142,000 deaths, while 155,000 new cases of lung cancer were diagnosed. Survival rates for patients with lung cancer have changed only minimally over the past twenty years and improvement in the management of these patients is a priority for medical oncologists. The epidemiology, pathology, clinical features, prognostic factors, and staging of the disease will be briefly discussed. The current approach to treatment will be reviewed, which includes the use of surgery, irradiation, and chemotherapy. Improvements in current therapy may include combined modality therapy. Future approaches to treatment of lung cancer may also be based on a better understanding of tumor cell biology. These approaches include determining the in vitro drug sensitivity of tumor specimens, investigating mechanisms of drug resistance, identifying tumor markers which suggest tum r sensitivity of chemotherapy, and detecting autocrine growth factors as possible therapeutic targets in lung cancer. The development of tools for early detection of patients at high risk to develop lung cancer and possible preventative measures will also be explored.
KW  - ASHP meeting abstracts--lung neoplasms therapy;
KW  - Antineoplastic agents--lung neoplasms--therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goldspiel, B. R.;
T1  - Levamisole and 5-FU: adjuvant therapy for colorectal cancer
CT  - Levamisole and 5-FU: adjuvant therapy for colorectal cancer
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1991/06/01/
VL  - 48
IS  - Jun
SP  - PI
EP  - 33
AD  - Warren G. Magnuson Clinical Center, Pharmacy Department, Bldg. 10, Room 1N-257, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 28-07107; Language: English; Chemical Name: Fluorouracil--51-21-8 Levamisole--14769-73-4; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2  - Colon cancer is a very common malignancy with an expected incidence of over 110,000 new cases to be diagnosed in 1991 and is second only to lung cancer in mortality rates. While surgery remains the primary treatment modality, over 50% of patients develop and die from recurrent or metastatic disease. Adjuvant therapy with fluorouracil (5-FU) alone, the most commonly used antineoplastic agent for colon cancer, uniformly produces low response rates with little effect on overall survival. Recent efforts at providing immune modulation using levamisole concomitantly with 5-FU has demonstrated a one-third reduction in recurrence and death-risk in patients with resected Duke's C colon cancer. These results have led to FDA approval for levamisole for use in combination with 5-FU in this population. Combination therapy with levamisole plus 5-FU is well tolerated, but careful monitoring for granulocytopenia is warranted.
KW  - Fluorouracil--and levamisole-;
KW  - Levamisole--and fluorouracil-;
KW  - ASHP meeting abstracts--colorectal neoplasms therapy;
KW  - Combined therapy--fluorouracil and levamisole--colorectal neoplasms;
KW  - Combined therapy--levamisole and fluorouracil--colorectal neoplasms;
KW  - Antineoplastic agents--colorectal neoplasms--combined therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Healy, Bernadine
AU  - Healy, B
T1  - From the National Institutes of Health.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/06/05/
VL  - 265
IS  - 21
M3  - journal article
SP  - 2777
EP  - 2777
SN  - 00987484
AB  - Presents abstracts of several studies sponsored by the U.S. National Institutes of Health.  'Antimicrobial Therapy Preferred for Acute Otitis Media,' by Phillip H. Kaleida and colleagues from the 1991 issue of 'Pediatrics'; 'Propafenone Reduces Paroxysmal Arrhythmias,' by Edward Pritchett and associates from the 1991 issue of 'Annals of Internal Medicine'; 'CD4 Linked to Exotoxin Shows Anti-HIV Activity in Primary Lymphocytes and Monocytes,' by Edward Berger and colleagues from the 1991 issue of the 'Journal of Infectious Diseases.'
KW  - MEDICAL research
KW  - OTITIS media
KW  - PROPAFENONE
KW  - LYMPHOCYTES
KW  - AMOXICILLIN
KW  - HIV (Viruses)
KW  - PHYSIOLOGY
KW  - ARRHYTHMIA
KW  - BACTERIAL toxins
KW  - DOXORUBICIN
KW  - MONOCYTES
KW  - CARDIOMYOPATHIES
KW  - RECOMBINANT proteins
KW  - TOXINS
KW  - TRANSFERASES
KW  - CD4 antigen
KW  - ACUTE diseases
KW  - THERAPEUTIC use
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 10415108; Healy, Bernadine Healy, B 1; Affiliation:  1: National Institutes of Health, Bethesda, MD 20892; Source Info: 6/5/91, Vol. 265 Issue 21, p2777; Subject Term: MEDICAL research; Subject Term: OTITIS media; Subject Term: PROPAFENONE; Subject Term: LYMPHOCYTES; Subject Term: AMOXICILLIN; Subject Term: HIV (Viruses); Subject Term: PHYSIOLOGY; Subject Term: ARRHYTHMIA; Subject Term: BACTERIAL toxins; Subject Term: DOXORUBICIN; Subject Term: MONOCYTES; Subject Term: CARDIOMYOPATHIES; Subject Term: RECOMBINANT proteins; Subject Term: TOXINS; Subject Term: TRANSFERASES; Subject Term: CD4 antigen; Subject Term: ACUTE diseases; Subject Term: THERAPEUTIC use; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Danford, Darla E.
AU  - Hubbard, Van S.
AU  - Combs, Gerald F.
AU  - Hall, Charles A.
AU  - Larsen, Lynn A.
AU  - Schnakenberg, David D.
T1  - Report on the Fourth Conference for Federally Supported Human Nutrition Research Units and Centers.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991/07//
VL  - 54
IS  - 1
M3  - Article
SP  - 164
EP  - 168
SN  - 00029165
AB  - The Fourth Conference for Federally Supported Human Nutrition Research Units and Centers, sponsored by the Interagency Committee on Human Nutrition Research, addressed two topics: nutrition and function, and nutrient interactions and toxicities. This article summarizes the conference's introductory remarks and the contents of the 34 papers presented. Future meetings of federally supported nutrition research units and centers will focus on other human nutrition research topics and will be held biennially. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 95875383; Danford, Darla E. 1; Hubbard, Van S.; Combs, Gerald F.; Hall, Charles A.; Larsen, Lynn A.; Schnakenberg, David D.; Affiliations: 1: Division of Nutrition Research Coordination, Building 31, Room 4B63, National Institutes of Health, Bethesda, MD 20892; Issue Info: Jul1991, Vol. 54 Issue 1, p164; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Zahm, Sheila Hoar
AU  - Cocco, Pierluigi
AU  - Blair, Aaron
T1  - Tobacco Smoking as a Risk Factor for Colon Polyps.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/07//
VL  - 81
IS  - 7
M3  - Article
SP  - 846
EP  - 849
PB  - American Public Health Association
SN  - 00900036
AB  - Background: Data from a cancer screening project among pattern makers were used to evaluate the association between tobacco smoking and prevalence of colon polyps. Methods: From 1981-1983, 549 White men were examined by flexible sigmoidoscopy and completed self-administered questionnaires including smoking histories. Results: One or more colon polyps were detected in 76 men. Standardized prevalence rates (SPR) for polyps increased by smoking category (never smoked = 0.094; ex-smokers = 0.118, current smokers = 0.214) and by cigarettes per day, years of smoking, and pack-years among both current and ex-smokers. Both adenomatous and hyperplastic polyps showed an association with smoking while other types of polyps and polyps with unspecified histology did not. The risk associated with smoking was greater for polyps greater than one centimeter in diameter. An interaction with occupational exposures was suggested by a greater increase in the SPR for polyps among current smokers employed as pattern makers for more than 10 years than among current smokers similarly employed for 10 years or less. Conclusions: Since at least some colon polyps are considered precursor lesions to colon cancer, one of the most common cancers in the United States, this report suggests that the possible link between colon polyps and smoking deserves further evaluation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLON (Anatomy)
KW  - POLYPS (Pathology)
KW  - TUMORS
KW  - SMOKING
KW  - CIGARETTES
KW  - TOBACCO
KW  - CIGARETTE smokers
KW  - EX-smokers
KW  - UNITED States
N1  - Accession Number: 9108050283; Zahm, Sheila Hoar 1 Cocco, Pierluigi 1 Blair, Aaron 1; Affiliation:  1: Occupational Studies Section, National Cancer Institute; Source Info: Jul1991, Vol. 81 Issue 7, p846; Subject Term: COLON (Anatomy); Subject Term: POLYPS (Pathology); Subject Term: TUMORS; Subject Term: SMOKING; Subject Term: CIGARETTES; Subject Term: TOBACCO; Subject Term: CIGARETTE smokers; Subject Term: EX-smokers; Subject Term: UNITED States; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sichieri, Rosely
AU  - Everhart, James E.
AU  - Roth, Harold
T1  - A prospective study of hospitalization with gallstone disease among women: Role of dietary Factors, Fasting Period, and Dieting.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/07//
VL  - 81
IS  - 7
M3  - Article
SP  - 880
EP  - 884
PB  - American Public Health Association
SN  - 00900036
AB  - Background: Dietary risk factors for the development of gallstones have not been clearly established. We analyzed data from a population-based prospective study to determine dietary risk factor for hospitalization with gallstone disease. Methods. We evaluated the role of dietary constituents, fasting, and dieting on subsequent hospitalization with gallstone disease among 4,730 women, ages 25 to 74 years, who participated in the first follow-up of the first National Health and Nutrition Examination Survey, Baseline dietary variables were established through a 24-hour dietary recall and a medical history. Proportional hazards models were used to calculate the effects of dietary variables while controlling for baseline risk factors. Results: After an average of 10 years follow-up, gallstone disease was confirmed by hospital records among 216 women who denied gallstone disease at the baseline examination. The hazard rate of hospitalization with gallstone disease increased with increasing with overnight fasting period and with dieting. Intake of fiber showed a small protective effect. The effect of energy intake was significant only, among women younger than age 50 years at baseline. Results were not affected by adjustment for known, risk factors for gallstone disease or other dietary factors. Conclusion: A long overnight fasting period, dieting, and low fiber intake may increase the risk of hospitalization with gallstone disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GALLSTONES
KW  - GALLBLADDER -- Diseases
KW  - HOSPITAL care
KW  - BILE ducts -- Diseases
KW  - CALCULI
KW  - MEDICAL care
KW  - FASTING
KW  - HEALTH
KW  - WOMEN -- Health
N1  - Accession Number: 9108050290; Sichieri, Rosely 1 Everhart, James E. 1 Roth, Harold 1; Affiliation:  1: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Epidemiology  and Data Systems Program; Source Info: Jul1991, Vol. 81 Issue 7, p880; Subject Term: GALLSTONES; Subject Term: GALLBLADDER -- Diseases; Subject Term: HOSPITAL care; Subject Term: BILE ducts -- Diseases; Subject Term: CALCULI; Subject Term: MEDICAL care; Subject Term: FASTING; Subject Term: HEALTH; Subject Term: WOMEN -- Health; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Harlan, Linda C.
AU  - Bernstein, Amy H.
AU  - Kessler, Larry G.
T1  - Cervical Cancer Screening: Who is Not Screened and Why?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/07//
VL  - 81
IS  - 7
M3  - Article
SP  - 885
EP  - 890
PB  - American Public Health Association
SN  - 00900036
AB  - Background: The decline in death rates from cervical cancer in the United States has been widely attributed to the use of Papanicolaou (Pap) smears for early detection of cervical cancer. Methods: Pap smear screening rates, beliefs about appropriate screening intervals and factors effecting screening were examined using 1987 National Health Interview Survey data. Results: Results indicate that through age 69, Blacks are screened at similar or higher rates than Whites. Hispanics, particularly those speaking only or mostly spanish, are least likely to have received a Pap smear within the last three year. Of women who had never heard of or never had a Pap smear, nearly 80 percent reported contact with a medical practitioner in the past two years, while more that 90 percent reported a contact in the past five years. Overall, the most frequently reported reason for not having a recent Pap smear was procrastinating or not believing it was necessary. Conclusions: Thus, in developing screening programs, Hispanics particularly Spanish speaker, must be targeted. In addition, educational programs should target unscreened women who forego the test due to underestimating its importance, procrastination, or because their medical care provider did not suggest the procedure. Women must be intensively educated that Pap smears should be scheduled routinely to detect asymptomatic cervical cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CERVICAL cancer
KW  - PAP test
KW  - WOMEN'S health services
KW  - CANCER -- Diagnosis
KW  - MORTALITY -- Statistics
KW  - MEDICAL care
KW  - MEDICAL screening
KW  - DIAGNOSIS
KW  - UNITED States
N1  - Accession Number: 9108050291; Harlan, Linda C. 1 Bernstein, Amy H. 1 Kessler, Larry G. 1; Affiliation:  1: National Cancer Institute; Source Info: Jul1991, Vol. 81 Issue 7, p885; Subject Term: CERVICAL cancer; Subject Term: PAP test; Subject Term: WOMEN'S health services; Subject Term: CANCER -- Diagnosis; Subject Term: MORTALITY -- Statistics; Subject Term: MEDICAL care; Subject Term: MEDICAL screening; Subject Term: DIAGNOSIS; Subject Term: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Illustrations: 7 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Benfante, Richard
AU  - Reed, Dwayne
AU  - Frank, John
T1  - Does Cigarette Smoking Have an Independent Effect on Coronary Heart Disease Incidence in the Elderly?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/07//
VL  - 81
IS  - 7
M3  - Article
SP  - 897
EP  - 899
PB  - American Public Health Association
SN  - 00900036
AB  - In order to evaluate the effects of cigarette smoking on coronary heart disease (CHD) in elderly persons in the Honolulu Heart Program, 1,394 men between ages 65 and 74 were followed during an average 12-year period for new cases of nonfatal myocardial infarction and fatal CHD. Incidence rates increased progressively in individuals classified at baseline as never, former and current smokers, respectively. The absolute excess risk associated with cigarette smoking was nearly twice as high in elderly compared with middle-aged men. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORONARY heart disease
KW  - HEART diseases
KW  - OLDER people -- Diseases
KW  - MYOCARDIAL infarction
KW  - SMOKING
KW  - CIGARETTE smokers
KW  - HEALTH
KW  - TOBACCO use
KW  - ORAL habits
N1  - Accession Number: 9108050294; Benfante, Richard 1 Reed, Dwayne 2 Frank, John 1; Affiliation:  1: Honolulu Heart Program  2: National Heart, Lung and Blood Institute; Source Info: Jul1991, Vol. 81 Issue 7, p897; Subject Term: CORONARY heart disease; Subject Term: HEART diseases; Subject Term: OLDER people -- Diseases; Subject Term: MYOCARDIAL infarction; Subject Term: SMOKING; Subject Term: CIGARETTE smokers; Subject Term: HEALTH; Subject Term: TOBACCO use; Subject Term: ORAL habits; Number of Pages: 3p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - KIM, YEOUNG A.
AU  - BARBEAU, WILLIAM E.
T1  - Evaluation of SDS-PAGE Method for Estimating Protein Digestibility.
JO  - Journal of Food Science
JF  - Journal of Food Science
Y1  - 1991/07//
VL  - 56
IS  - 4
M3  - Article
SP  - 1082
EP  - 1086
SN  - 00221147
AB  - In a new technique digestibility of unheated and autoclaved soy protein concentrate (SPC) samples was determined in vitro by SDS-PAGE. Results were compared with those determined by the pH drop method and with apparent in vivo digestibility in rats. Results of the pH drop method correlated more highly (r=0.95) with apparent in vivo digestibility than SDS-PAGE results (r= 0.92). However, the SDS-PAGE technique had two advantages: it allowed estimation of the molecular weight(s) of polypeptides/peptides remaining in protein hydrolyzates and from densitometric analysis, visualization of the process of protein digestion. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOY proteins
KW  - MOLECULAR weights
KW  - HYDROGEN-ion concentration
KW  - RATS as laboratory animals
KW  - POLYPEPTIDES
N1  - Accession Number: 63003203; KIM, YEOUNG A. 1 BARBEAU, WILLIAM E. 1; Affiliation:  1: Author Kim is with the National Institute on Alcohol Abuse and Alcoholism, National Institute of Health (NIH), Rockville, MD 20857. Author Barbeau is with the Dept. of Human Nutrition & Foods, Virginia Polytechnic Institute & State Univ., Blacksburg, VA 24061-0430.; Source Info: Jul1991, Vol. 56 Issue 4, p1082; Subject Term: SOY proteins; Subject Term: MOLECULAR weights; Subject Term: HYDROGEN-ion concentration; Subject Term: RATS as laboratory animals; Subject Term: POLYPEPTIDES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/j.1365-2621.1991.tb14647.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gottesman, S.
AU  - Stout, V.
T1  - Regulation of capsular polysaccharide synthesis in Escherichia coli K12.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/07//
VL  - 5
IS  - 7
M3  - Article
SP  - 1599
EP  - 1606
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Synthesis of the capsular polysaccharide colanic acid in <em>Escherichia coli</em> K12 is regulated by a complex network of regulatory proteins. This regulation is expressed at the level of transcription of the <em>cps</em> (capsular polysaccharide synthesis) genes. Two positive regulators, RcsA and RcsB, are necessary for maximal capsule expression. The availability of RcsA is normally limited because the RcsA protein is rapidly degraded by the Lon ATP-dependent protease. Therefore Lon acts, indirectly, as a negative regulator of capsule synthesis. The sequence predicted for RcsB suggests that it is the effector component of a two-component system; a protein with homology to sensors, RcsC, also plays a role in capsule regulation. We propose a model for capsule synthesis in which RcsA interacts with RcsB to stimulate transcription of the <em>cps</em> genes. The mechanism of regulation of colanic acid synthesis in <em>E. coli</em> may apply to other capsules in a variety of Gram-negative bacteria. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Proteolytic enzymes
KW  - Gram-negative bacteria
KW  - Polysaccharide synthesis
KW  - Genetic transcription
KW  - Proteins
KW  - Genes
N1  - Accession Number: 16253500; Gottesman, S. 1; Stout, V. 1; Affiliations: 1: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA; Issue Info: Jul1991, Vol. 5 Issue 7, p1599; Thesaurus Term: Escherichia coli; Thesaurus Term: Proteolytic enzymes; Thesaurus Term: Gram-negative bacteria; Subject Term: Polysaccharide synthesis; Subject Term: Genetic transcription; Subject Term: Proteins; Subject Term: Genes; Number of Pages: 8p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pillar, Barbara
T1  - The Safety of Medical Devices and the Role of the FDA.
JO  - Nursing Economic$
JF  - Nursing Economic$
Y1  - 1991/07//Jul/Aug91
VL  - 9
IS  - 4
M3  - Article
SP  - 284
EP  - 286
PB  - Jannetti Publications, Inc.
SN  - 07461739
AB  - The U.S. Food and Drug Administration (FDA) is the only agency mandated to regulate medical devices through the Food, Drug, and Cosmetic Act of 1938, with additional authority under the Medical Devices Amendments enacted in 1976. Under the Act, a medical device is defined as an instrument, apparatus, implement, machine, contrivance, implant, in vitro reagent, or other article intended for use in the diagnosis of disease and the cure, mitigation, treatment, or prevention of disease. This definition of devices that require regulation extends to the parts or accessories of devices. Since the 1976 Amendments, approximately 36,000 devices and device modifications have entered the health care market.
KW  - MEDICAL equipment
KW  - MEDICAL care
KW  - DIAGNOSIS
KW  - PREVENTIVE medicine
KW  - UNITED States
KW  - UNITED States. Food & Drug Administration
N1  - Accession Number: 12180809; Pillar, Barbara 1; Affiliation:  1: Member, National Center for Nursing Research, National Institutes of Health, Bethesda, MD.; Source Info: Jul/Aug91, Vol. 9 Issue 4, p284; Subject Term: MEDICAL equipment; Subject Term: MEDICAL care; Subject Term: DIAGNOSIS; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05450-034
AN  - 2006-05450-034
AU  - Insel, Thomas R.
T1  - Hormones and Behavior--Revisited.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1991/07//
VL  - 36
IS  - 7
SP  - 599
EP  - 600
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05450-034. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Insel, Thomas R.; Section on Comparative Studies of Brain and Behavior, National Institute of Mental Health, Poolesville, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Neuroendocrinology; Psychoneuroimmunology. Minor Descriptor: Body Temperature; Hormones; Memory; Stress. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Reviewed Item: Brush, F. Robert (Ed); Levine, Seymour (Ed). Psychoendocrinology=San Diego, CA: Academic Press, 1989. 587 pp. $95.00; 1989. Page Count: 2. Issue Publication Date: Jul, 1991. 
AB  - Reviews the book, Psychoendocrinology by F. Robert Brush and Seymour Levine (Eds.) (see record [rid]1989-98563-000[/rid]). This book is dedicated to the late Frank Beach, who in 1948 published his first volume of Hormones and Behavior. Following the Beach tradition, reproductive and maternal behaviors are the focus for the first half of this volume, with an eye to the way in which sensory afferents regulate both endocrine and behavioral responses. Chapters on hormones and memory, stress, and temperature regulation make up most of the second half, with an introduction to opioids and behavior thrown in as well. Unfortunately, the editors have chosen to cover only a limited segment of the entire field of psychoendocrinology: Feeding, aggression, and fear are all exciting fields of research that are not mentioned. Developmental aspects of hormone function and clinical studies of hormone-behavior relations also get short shrift. But what is presented here is excellent. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hormones
KW  - memory
KW  - stress
KW  - temperature regulation
KW  - psychoendocrinology
KW  - 1991
KW  - Neuroendocrinology
KW  - Psychoneuroimmunology
KW  - Body Temperature
KW  - Hormones
KW  - Memory
KW  - Stress
KW  - 1991
U2  - Brush, F. Robert (Ed); Levine, Seymour (Ed). (1989); Psychoendocrinology; San Diego, CA: Academic Press, 1989. 587 pp. $95.00; 0-12-137952-3.
DO  - 10.1037/029932
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-05450-047
AN  - 2006-05450-047
AU  - Crawley, Jacqueline N.
T1  - Heuristic Animal Models of Human Psychoses.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1991/07//
VL  - 36
IS  - 7
SP  - 613
EP  - 614
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05450-047. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Crawley, Jacqueline N.; Unit on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Affective Disorders; Animal Models; Major Depression; Psychosis. Classification: Affective Disorders (3211). Population: Human (10). Reviewed Item: Koob, George F. (Ed); Ehlers, Cindy L. (Ed); Kupfer, David J. (Ed). Animal Models of Depression=Boston: Birkhauser, 1989. 295 pp. (Basel, Switzerland); (U.S.). $55.00; 1989. Page Count: 2. Issue Publication Date: Jul, 1991. 
AB  - Reviews the book, Animal Models of Depression by George F. Koob, Cindy L. Ehlers, and David J. Kupfer (Eds.) (1989). Animal models of human neuropsychiatric diseases are an essential link between new discoveries in the neurosciences and better clinical treatments. Koob, Ehlers, and Kupfer provide the first full-length volume on animal models of human depressive disorders. The assembled chapters fulfill the goal, as introduced by Koob, 'to review the status, problems, promises, and relevance of animal models to the clinical conditions of affective disorders.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - affective disorders
KW  - depression
KW  - animal models
KW  - psychoses
KW  - 1991
KW  - Affective Disorders
KW  - Animal Models
KW  - Major Depression
KW  - Psychosis
KW  - 1991
U2  - Koob, George F. (Ed); Ehlers, Cindy L. (Ed); Kupfer, David J. (Ed). (1989); Animal Models of Depression; Boston: Birkhauser, 1989. 295 pp. (Basel, Switzerland); (U.S.). $55.00; 3-7643-3407-X; 0-8176-3407-X.
DO  - 10.1037/029945
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Louis, John M.
AU  - McDonald, Richard A.
AU  - Nashed, Nashaat T.
AU  - Wondrak, Ewald M.
AU  - Jerina, Donald M.
AU  - Oroszlan, Stephen
AU  - Mora, Peter T.
T1  - Autoprocessing of the HIV-1 protease using purified wild-type and mutated fusion proteins expressed at high levels in <em>Escherichia coli</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/07/15/
VL  - 199
IS  - 2
M3  - Article
SP  - 361
EP  - 369
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Various constructs of the human immunodeficiency virus, type 1 (HIV-1) protease containing flanking Pol region sequences were expressed as fusion proteins with the maltose-binding protein of the male gene of Escherichia coli. The full-length fusion proteins did not exhibit self-processing in E. coli, thereby allowing rapid purification by affinity chromatography on cross-linked amylose columns. Denaturation of the fusion protein in 5 M urea, followed by renaturation, resulted in efficient site-specific autoprocessing to release the 11-kDa protease. Rapid purification involving two column steps gave an HIV-1 protease preparation of > 95% purity (specific activity ≈ 8500 pmol · min-1 · μg protease-1) with an overall yield of about 1 mg/1 culture. Incubation of an inactive mutant protease fusion protein with the purified wild-type protease resulted in specific trans cleavage and release of the mutant protease. Analysis of products of the HIV-1 fusion proteins containing mutations at either the N- or the C-terminal protease cleavage sites indicated that blocking one of the cleavage sites influences the cleavage at the non-mutated site. Such mutated full-length and truncated protease fusion proteins possess very low levels of proteolytic activity (≈ 5 pmol · min -1 · μg protein-1). [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV (Viruses)
KW  - PROTEOLYTIC enzymes
KW  - MUTATION (Biology)
KW  - MALTOSE
KW  - CARRIER proteins
KW  - ESCHERICHIA coli
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
N1  - Accession Number: 13698989; Louis, John M. 1 McDonald, Richard A. 1 Nashed, Nashaat T. 2 Wondrak, Ewald M. 3 Jerina, Donald M. 2 Oroszlan, Stephen 3 Mora, Peter T. 1; Affiliation:  1: Division of Cancer Biology and Diagnosis, National Cancer Institutes of Health, Bethesda MD, USA  2: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, USA  3: Laboratory of Molecular Virology and Carcinogenesis, ABL-Basis Research Program, NCI-Frederick Cancer Research and Development Centre, Frederick MD, USA; Source Info: 7/15/91, Vol. 199 Issue 2, p361; Subject Term: HIV (Viruses); Subject Term: PROTEOLYTIC enzymes; Subject Term: MUTATION (Biology); Subject Term: MALTOSE; Subject Term: CARRIER proteins; Subject Term: ESCHERICHIA coli; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Linn, Shai
AU  - Fulwood, Robinson
AU  - Carroll, Margaret
AU  - Brook, J. Gerald
AU  - Johnson, Clifford
AU  - Kalsbeek, William D.
AU  - Rifkind, Basil M.
T1  - Serum Total Cholesterol: HDL Cholesterol Ratios in US White and Black Adults by Selected Demographic and Socioeconomic Variables, (HANES II).
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/08//
VL  - 81
IS  - 8
M3  - Article
SP  - 1038
EP  - 1043
PB  - American Public Health Association
SN  - 00900036
AB  - Background: Framingham Study findings suggest that total cholesterol (TC):High density lipoprotein cholesterol (HDL-C) ratio is a useful summary of the joint contribution of TC and HDL-C to coronary heart disease (CHD) risk. Information on the distribution of TC:HDL-C in the US population is limited to selected populations and the relationship of the ratio distribution and its correlates has received little attention. Method: TC/HDL-C ratios were examined in a representative sample of the United States adult population ages 20 to 74 years, between February 1976 and February 1980 during NHANES II, using stratification and multivariate regression analyses. Results: Age-adjusted mean ratios were higher in men compared with women and were higher in Whites compared with Blacks. White men had the highest TC/HDL-C mean ratios. These relationships remained after stratification by age, education, body mass index, alcohol use, cigarette smoking, and physical activity. Using multivariate analyses, the ratios were positively related to BMI, age, and smoking; and negatively related to female sex, alcohol use, being Black, and physical activity. Conclusions: Using a ratio reference point of greater than or equal to 4.5 from the Framingham study, at least an estimated 44 million persons ages 25 to 74 years in the US were found to be at higher risk of developing coronary heart disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHOLESTEROL
KW  - HIGH density lipoproteins
KW  - CORONARY heart disease
KW  - DRINKING of alcoholic beverages
KW  - SMOKING
KW  - PHYSICAL fitness
KW  - MULTIVARIATE analysis
KW  - HEART diseases
KW  - UNITED States
N1  - Accession Number: 9109090590; Linn, Shai 1,2 Fulwood, Robinson 3 Carroll, Margaret 3 Brook, J. Gerald 1 Johnson, Clifford 3 Kalsbeek, William D. 4 Rifkind, Basil M. 1; Affiliation:  1: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, NIH, Bethesda.  2: Clinical Epidemiology Unit, Rambam Medical Center, Haifa, Israel.  3: Nutrition Statistics Branch, National Center for Health Statistics, Hyattsville, MD.  4: Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina, Chapel Hill.; Source Info: Aug1991, Vol. 81 Issue 8, p1038; Subject Term: CHOLESTEROL; Subject Term: HIGH density lipoproteins; Subject Term: CORONARY heart disease; Subject Term: DRINKING of alcoholic beverages; Subject Term: SMOKING; Subject Term: PHYSICAL fitness; Subject Term: MULTIVARIATE analysis; Subject Term: HEART diseases; Subject Term: UNITED States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 6p; Illustrations: 7 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Haverkos, Harry W.
AU  - Steel, Elizabeth
T1  - Crack Cocaine, Fellatio, and the Transmission of HIV.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/08//
VL  - 81
IS  - 8
M3  - Letter
SP  - 1078
EP  - 1079
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented about the transmission of HIV infections through sexual contact between crack cocaine users and other nonintravenous drug abusers and oral sex.
KW  - LETTERS to the editor
KW  - HIV infections
N1  - Accession Number: 20671839; Haverkos, Harry W. 1 Steel, Elizabeth 1; Affiliation:  1: National Institute on Drug Abuse, Rockville, Md. Direct inquiries to Ms. Steel, 5600 Fishers Lane, Room 10A-38 (Parklawn Building), Rockville, MD 20857; Source Info: Aug1991, Vol. 81 Issue 8, p1078; Subject Term: LETTERS to the editor; Subject Term: HIV infections; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 108181332
T1  - Preclinical markers in studies of Parkinson's disease.
AU  - Ellenberg, J H
Y1  - 1991/08//
N1  - Accession Number: 108181332. Language: English. Entry Date: 20120504. Revision Date: 20150712. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985102R. 
KW  - Parkinson Disease -- Diagnosis
KW  - Biological Markers
KW  - Brain -- Metabolism
KW  - Brain -- Pathology
KW  - Cell Count
KW  - Dopamine -- Metabolism
KW  - Human
KW  - Neurons -- Metabolism
KW  - Neurons -- Pathology
KW  - Parkinson Disease -- Etiology
KW  - Parkinson Disease -- Therapy
KW  - Prospective Studies
KW  - Reproducibility of Results
KW  - Sensitivity and Specificity
KW  - Statistics
SP  - 16
EP  - 24
JO  - Geriatrics
JF  - Geriatrics
JA  - GERIATRICS
VL  - 46
IS  - 8
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
SN  - 0016-867X
AD  - Biometry and Field Studies Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
U2  - PMID: 1894141.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Dastych, J.
AU  - Costa, J. J.
AU  - Thompson, H. L.
AU  - Metcalfe, D. D.
T1  - Mast cell adhesion to fibronectin.
JO  - Immunology
JF  - Immunology
Y1  - 1991/08//
VL  - 73
IS  - 4
M3  - Article
SP  - 478
EP  - 484
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The MCP-5 murine mast cell line, as well as primary bone marrow-derived cultured mast cells (BMCMC), are demonstrated to bind to fibronectin, a ubiquitous adhesion protein of the extracellular matrix. BMCMC required activation by phorbol myristate acetate (PMA) to adhere to fibronectin, whereas MCP-5 displayed spontaneous adherence. The binding of both MCP-5 and BMCMC was dose dependent, with maximal adhesion at a fibronectin concentration of 20 μg/mi. The 120,000 molecular weight (MW) proteolytic fragment of fibronectin containing the RGDS cell attachment site was able to substitute for the native fibronectin molecule in promoting mast cell attachment. Mast cell adhesion to fibronectin, in addition, could be inhibited by the RGDS peptide alone. These data suggest that, in addition to the previously described mast cell-laminin interactions, mast cells also adhere to fibronectin, thus providing further insight into their tissue localization and possible roles in processes such as wound healing and fibrosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cells
KW  - FIBRONECTINS
KW  - EXTRACELLULAR matrix
KW  - CELL lines
KW  - WOUND healing
KW  - MOLECULAR weights
N1  - Accession Number: 13402549; Dastych, J. 1 Costa, J. J. 1 Thompson, H. L. 1 Metcalfe, D. D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug91, Vol. 73 Issue 4, p478; Subject Term: MAST cells; Subject Term: FIBRONECTINS; Subject Term: EXTRACELLULAR matrix; Subject Term: CELL lines; Subject Term: WOUND healing; Subject Term: MOLECULAR weights; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Amagai, Masayuki
AU  - Elgart, George W.
AU  - Klaus-kovtun, Vera
AU  - Stanley, John R.
T1  - Southern Analysis of the 230-kD Bullous Pemphigoid Antigen Gene in Normal Humans, Animals, and Patients with Junctional Epidermolysis Bullosa.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/08//
VL  - 97
IS  - 2
M3  - Article
SP  - 249
EP  - 253
SN  - 0022202X
AB  - To begin to characterize the 230-kD bullous pemphigoid antigen (BPA) gene, we performed Southern analysis on genomic DNA with probes derived from 7 kb of cDNA that spans most of the coding region of this hemidesmosomal plaque protein. When hybridized to a 1-kb fragment of this BPA cDNA, normal human genomic DNA digested with EcoRI, BamHI, PstI, HindIII, or EcoRV showed only a single band, which was unique for each enzyme, indicating a single human gene for BPA. To determine if a related gene exists in animals, we used probes covering the full 7 kb of cDNA for Southern analysis of genomic DNA from various vertebrates. A related gene was detected in other mammals (monkey, cow, dog, rabbit, mouse, and rat) but not in chicken, frog, or fish. Under these same hybridization conditions a probe for human β-actin could detect an actin gene in all these species. Furthermore, immunofluorescence showed that an antibody raised against portions of the 230-kD BPA bound to the epidermal basement membrane of mammals but not that of a bird or amphibian. Finally, because most patients with junctional epidermolysis bullosa (JEB) have defective hemidesmosomes in ultrastructure, and probably function, we analyzed genomic DNA from these patients. No restriction fragment length polymorphisms (RFLP) were detected when the DNA from 11 normals and 8 JEB patients (representing 16 possible defective genes) was digested with BamHI, EcoRI, or PstI and hybridized to any part of the cDNA. These findings indicate that 1) there is a single BPA gene in humans; 2) a closely related gene exists in other mammals but not birds, amphibia, or fish; and 3) gross abnormalities of the BPA gene are not characteristic of JEB patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMOLYSIS bullosa
KW  - IMMUNOCYTOCHEMISTRY
KW  - EPITHELIAL cells
KW  - DNA
KW  - IMMUNOFLUORESCENCE
KW  - ACTIN
N1  - Accession Number: 12480358; Amagai, Masayuki 1 Elgart, George W. 1 Klaus-kovtun, Vera 1 Stanley, John R. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug91, Vol. 97 Issue 2, p249; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: IMMUNOCYTOCHEMISTRY; Subject Term: EPITHELIAL cells; Subject Term: DNA; Subject Term: IMMUNOFLUORESCENCE; Subject Term: ACTIN; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12480358
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dawson, Deborah A.
T1  - Family structure and children's health and well-being: Data from the 1988 National Health Interview Survey on Child Health.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1991/08//
VL  - 53
IS  - 3
M3  - Article
SP  - 573
EP  - 584
SN  - 00222445
AB  - According to data from a nationally representative sample of 17,110 children under age 18, children living with single mothers or with mothers and stepfathers were more likely than those living with both biological parents to have repeated a grade of school, to have been expelled, to have been treated for emotional or behavioral problems in the year preceding interview, and to have elevated scores for behavioral problems and health vulnerability. Compared to children living with both biological parents, children of divorce experienced an increased risk of accidental injury, and those living with a single mother were at increased risk of asthma. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FAMILIES
KW  - CHILDREN -- Health
KW  - PARENT & child
KW  - STEPFAMILIES
KW  - DOMESTIC relations
KW  - Child Rearing and Parental Roles
N1  - Accession Number: 9110070189; Dawson, Deborah A. 1; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism; Source Info: Aug91, Vol. 53 Issue 3, p573; Subject Term: FAMILIES; Subject Term: CHILDREN -- Health; Subject Term: PARENT & child; Subject Term: STEPFAMILIES; Subject Term: DOMESTIC relations; Author-Supplied Keyword: Child Rearing and Parental Roles; Number of Pages: 12p; Illustrations: 7 Charts; Document Type: Article; Full Text Word Count: 7984
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bachrack, Christina A.
AU  - London, Kathryn A.
AU  - Maza, Penelope L.
T1  - On the Path to Adoption: Adoption Seeking in the United States, 1988.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1991/08//
VL  - 53
IS  - 3
M3  - Article
SP  - 705
EP  - 718
SN  - 00222445
AB  - Data from the National Survey of Family Growth provide the basis for the first estimate based on direct measures of the population seeking to adopt in the United States. Over 2 million women of reproductive age were estimated to have ever sought to adopt, and about 200,000 women were estimated to be currently seeking. Results of logistic regression models predicting ever having sought adoption indicate that adoption seeking is primarily a function of desire for children, coupled with inability or difficulty in having them. However, these conditions do not inevitably lead to adoption seeking. Black and nonblack women are equally likely to have sought to adopt, but adoption seeking is less closely tied to fertility desires and ability to have children among black than nonblack women. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADOPTION
KW  - FOSTER home care
KW  - PARENT & child
KW  - FAMILIES
KW  - UNITED States
KW  - CHILD CARE, PROBLEMS, AND TREATMENT
N1  - Accession Number: 9110070200; Bachrack, Christina A. 1 London, Kathryn A. 2,3 Maza, Penelope L. 4,5; Affiliation:  1: National Institute of Child Health and Human Development  2: National Center for Health Statistics  3: Family Growth Survey Branch, Room 840, 6525 Belcrest Road, Hyattsville, MD 20782  4: Administration for Children, Youth and Families  5: Children's Bureau, Box 1182, Washington, DC 20013; Source Info: Aug91, Vol. 53 Issue 3, p705; Subject Term: ADOPTION; Subject Term: FOSTER home care; Subject Term: PARENT & child; Subject Term: FAMILIES; Subject Term: UNITED States; Author-Supplied Keyword: CHILD CARE, PROBLEMS, AND TREATMENT; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 623999 All other residential care facilities; NAICS/Industry Codes: 624110 Child and Youth Services; Number of Pages: 14p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article; Full Text Word Count: 8384
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bhat, K. S.
AU  - Gibbs, C. P.
AU  - Barrera, O.
AU  - Morrison, S. G.
AU  - Jähnig, F.
AU  - Stern, A.
AU  - Kupsch, E. -M.
AU  - Meyer, T. F.
AU  - Swanson, J.
T1  - The opacity proteins of Nelsseria gonorrhoeae strain MS11 are encoded by a family of 11 complete genes.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/08//
VL  - 5
IS  - 8
M3  - Article
SP  - 1889
EP  - 1901
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Variants of <em>Neisseria gonorrhoeae</em> MS11 show distinct colony morphologies because of the expression of a class of surface components called opacity (Opa, Pil) proteins. Southern analyses combined with molecular cloning of genomic DNA from a single variant of MS11 has identified 11 <em>opa</em> genes contained in separate loci. These <em>opa</em> genes code for distinct opacity proteins which are distinguishable at their variable domains. The <em>opa</em> gene analyses were also extended to divergent variants of MS11. These studies have shown that, during <em>in vitro</em> and <em>in vivo</em> culture, 10 of the 11 opa genes did not undergo significant change in their primary sequence. However, in these variants, one gene (<em>opaE</em>) underwent non-reciprocal inter-<em>opa</em> recombinations to generate newer Opa variants. Phylogenic analysis of the <em>opa</em> gene sequences suggests that the opa gene family have evolved by a combination of gene duplication, gene replacement and partial inter-<em>opa</em> recombination events. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Proteins
KW  - Neisseria gonorrhoeae
KW  - Molecular cloning
KW  - Genes
KW  - DNA
N1  - Accession Number: 16381972; Bhat, K. S. 1; Gibbs, C. P. 2; Barrera, O. 1; Morrison, S. G. 1; Jähnig, F. 2; Stern, A. 2; Kupsch, E. -M. 2; Meyer, T. F. 2; Swanson, J. 1; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana 59840, USA; 2: Max-Planck-lnstitut für Biologie, Abteilung Infektionsbiologie, Spemannstraße 34, D-7400 Tübingen, Germany; Issue Info: Aug1991, Vol. 5 Issue 8, p1889; Subject Term: Proteins; Subject Term: Neisseria gonorrhoeae; Subject Term: Molecular cloning; Subject Term: Genes; Subject Term: DNA; Number of Pages: 13p; Illustrations: 7 Diagrams, 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Mathiopoulos, C.
AU  - Mueller, J. P.
AU  - Slack, F. J.
AU  - Murphy, C. G.
AU  - Patankar, S.
AU  - Bukusoglu, G.
AU  - Sonenshein, A. L.
T1  - A Bacillus subtilis dipeptide transport system expressed early during sporulation.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/08//
VL  - 5
IS  - 8
M3  - Article
SP  - 1903
EP  - 1913
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Two previously identified <em>Bacillus subtilis</em> DNA segments, <em>dciA</em> and <em>dciB</em>, whose transcripts accumulate very rapidly after induction of sporulation, were found in the same 6.2 kb transcription unit, now known as the <em>dciA</em> operon. Analysis of the sequence of the <em>dciA</em> operon showed that its putative products are homologous to bacterial peptide transport systems. The product of the fifth gene, DciAE, is similar to peptide-binding proteins from <em>Escherichia coli</em> and <em>Salmonelia typhimurium</em> (DppA and OppA) and <em>B. subtilis</em> (OppA). A null mutation in <em>dciAE</em> abolished the ability of a proline auxotroph to grow in a medium containing the dipeptide Pro-Gly as sole proline source, suggesting that the <em>dciA</em> operon encodes a dipeptide transport system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bacillus subtilis
KW  - Bacillus (Bacteria)
KW  - Genetic transcription
KW  - Operons
KW  - Genes
N1  - Accession Number: 16381973; Mathiopoulos, C. 1,2; Mueller, J. P. 1; Slack, F. J. 1; Murphy, C. G. 1; Patankar, S. 1; Bukusoglu, G. 1; Sonenshein, A. L. 1; Affiliations: 1: Department of Molecular Biology and Microbiology, Tufts University Health Sciences Campus, 136 Harrison Avenue, Boston, Massachusetts 02111, USA; 2: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Aug1991, Vol. 5 Issue 8, p1903; Subject Term: Bacillus subtilis; Subject Term: Bacillus (Bacteria); Subject Term: Genetic transcription; Subject Term: Operons; Subject Term: Genes; Number of Pages: 11p; Illustrations: 3 Diagrams, 3 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Slack, F. J.
AU  - Mueller, J. P.
AU  - Strauch, M. A.
AU  - Mathiopoulos, C.
AU  - Sonenshein, A. L.
T1  - Transcriptional regulation of a Bacillus subtilis dipeptide transport operon.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/08//
VL  - 5
IS  - 8
M3  - Article
SP  - 1915
EP  - 1925
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The <em>Bacillus subtilis dciA</em> operon, which encodes a dipeptide transport system, was induced rapidly by several conditions that caused the cells to enter stationary phase and initiate sporulation. The <em>in vivo</em> start point of transcription was mapped precisely and shown to correspond to a site of transcription initiation <em>in vitro</em> by the major vegetative form of RNA polymerase. Post-exponential expression was prevented by a mutation in the <em>spoOA</em> gene (whose product is a known regulator of early sporulation genes) but was restored in a spoOA abrB double mutant. This implicated AbrB, another known regulator, as a repressor of <em>dciA</em>. In fact, purified AbrB protein bound to a portion of the <em>dciA</em> promoter region, protecting it against DNase I digestion. Expression of <em>dciA</em> in growing cells was also repressed independently by glucose and by a mixture of amino acids; neither of these effects was mediated by AbrB. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bacillus subtilis
KW  - Bacillus (Bacteria)
KW  - Genetic transcription
KW  - Operons
KW  - RNA polymerases
N1  - Accession Number: 16382146; Slack, F. J. 1; Mueller, J. P. 1; Strauch, M. A. 2; Mathiopoulos, C. 1,3; Sonenshein, A. L. 1; Affiliations: 1: Department of Molecular Biology and Microbiology, Tufts University Health Sciences Campus, 136 Harrison Avenue, Boston, Massachusetts 02111, USA; 2: Division of Cellular Biology, Scripps Clinic Research Foundation, 10666 North Torrey Pines Road, La Jolla, California 92037, USA; 3: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Aug1991, Vol. 5 Issue 8, p1915; Subject Term: Bacillus subtilis; Subject Term: Bacillus (Bacteria); Subject Term: Genetic transcription; Subject Term: Operons; Subject Term: RNA polymerases; Number of Pages: 11p; Illustrations: 5 Diagrams, 1 Chart, 6 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104746435
T1  - Depression and the chronic pain experience.
AU  - Haythornthwaite, J A
AU  - Sieber, W J
AU  - Kerns, R D
Y1  - 1991/08//1991 Aug
N1  - Accession Number: 104746435. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Beck Depression Inventory (BDI); Marlowe-Crowne Social Desirability Scale. NLM UID: 7508686. 
KW  - Depression -- Psychosocial Factors
KW  - Pain -- Psychosocial Factors
KW  - Activities of Daily Living
KW  - Adult
KW  - Aged
KW  - Chronic Disease
KW  - Depression -- Complications
KW  - Disability Evaluation
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Multivariate Analysis
KW  - Pain -- Complications
KW  - Pain Measurement
KW  - Psychological Tests
KW  - Marlowe-Crowne Social Desirability Scale
SP  - 177
EP  - 184
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 46
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - National Institute on Aging, Baltimore, MD 21224.
U2  - PMID: 1749640.
DO  - 10.1016/0304-3959(91)90073-7
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Tsuda, Masahiko
AU  - Kikuchi, Takanobu
AU  - Yamaki, Kunihiko
AU  - Shinohara, Toshimichi
T1  - The mouse S-antigen gene.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/08/15/
VL  - 200
IS  - 1
M3  - Article
SP  - 95
EP  - 101
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have characterized a gene for mouse S-antigen and compared its sequence with that of corresponding human and two recently published Drosophila S-antigen genes. The mouse S-antigen gene was approximately 50 kbp in length and consisted of 16 exons and 15 introns. The length of most exons was less than 100 bp and the smallest one was only 10 bp. In contrast, the length of most introns was larger than 2 kbp and the gene consisted of 97% intron and 3% exon. Both splice sites for donor and accepter were in good agreement with the GT/AG rule. S-antigen genes in human and mouse were highly conserved. In contrast, genes for the Drosophila 49-kDa arrestin homolog and arrestin consist of three introns and four exons and two introns and three exons, respectively. The 5'-flanking region of the mouse S-antigen gene, approximately 1.0 kbp long, had no regulatory elements for transcription such as the TATA, CAAT and GC boxes, while a Drosophila arrestin gene has TATA and CAAT boxes. Interestingly, the 5'-flanking region of the mouse gene had promoter activity in an in vitro transcription assay using a nuclear extract of rat brain. A major transcription start site was found at 387 bp upstream from the translation start codon ATG in mouse. From our results, and those of others, we suggest that the S-antigen gene has evolved from a comman ancestor gene by either insertion or deletion of introns. Such an alteration of gene structure may have played a role in the evolution of the S-antigen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - DROSOPHILA
KW  - INTRONS
KW  - EXONS (Genetics)
KW  - TRANSCRIPTION
KW  - HEREDITY
N1  - Accession Number: 14498025; Tsuda, Masahiko 1 Kikuchi, Takanobu 1 Yamaki, Kunihiko 1 Shinohara, Toshimichi 1; Affiliation:  1: Molecular Biology Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health Bethesda, MD, USA.; Source Info: 8/15/91, Vol. 200 Issue 1, p95; Subject Term: ANTIGENS; Subject Term: DROSOPHILA; Subject Term: INTRONS; Subject Term: EXONS (Genetics); Subject Term: TRANSCRIPTION; Subject Term: HEREDITY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-05452-024
AN  - 2006-05452-024
AU  - Cole, Pamela M.
T1  - Grim Family Tales: When Wives Murder Abusive Husbands.
JF  - Contemporary Psychology: APA Review of Books
JO  - Contemporary Psychology: APA Review of Books
Y1  - 1991/09//
VL  - 36
IS  - 9
SP  - 768
EP  - 769
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05452-024. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Cole, Pamela M.; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Battered Females; Etiology; Family; Society; Wives. Minor Descriptor: Autobiography; Domestic Violence; Legal Processes. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Reviewed Item: Walker, Lenore E. Terrifying Love: Why Battered Women Kill and How Society Responds=New York: Harper & Row, 1989. 342 pp. $18.95; $9.95; 1989. Page Count: 2. Issue Publication Date: Sep, 1991. 
KW  - family violence
KW  - grim family
KW  - battered women
KW  - etiology
KW  - legal processes
KW  - autobiography
KW  - wives
KW  - society
KW  - 1991
KW  - Battered Females
KW  - Etiology
KW  - Family
KW  - Society
KW  - Wives
KW  - Autobiography
KW  - Domestic Violence
KW  - Legal Processes
U2  - Walker, Lenore E. (1989); Terrifying Love: Why Battered Women Kill and How Society Responds; New York: Harper & Row, 1989. 342 pp. $18.95; $9.95; 0-06-016160-4 (Hardcover); 0-06-016160-4 (Paperback).
DO  - 10.1037/030148
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DP  - EBSCOhost
DB  - pvh
ER  - 

TY  - JOUR
ID  - 2006-05452-053
AN  - 2006-05452-053
AU  - Keller, Barbara B.
T1  - Summary of Research on Children's Anxiety Disorders.
JF  - Contemporary Psychology: APA Review of Books
JO  - Contemporary Psychology: APA Review of Books
Y1  - 1991/09//
VL  - 36
IS  - 9
SP  - 799
EP  - 800
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05452-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Keller, Barbara B.; National Institute of Mental Health, Child Psychiatry Branch, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety Disorders; Child Attitudes; Child Psychology. Classification: Neuroses & Anxiety Disorders (3215). Population: Human (10). Reviewed Item: Klein, Rachel G.; Last, Cynthia G. Anxiety Disorders in Children=Newbury Park, CA: Sage, 1989. 140 pp. $19.95 hardcover; $12.95 paperback; 1989. Page Count: 2. Issue Publication Date: Sep, 1991. 
KW  - clinical child psychology
KW  - anxiety disorders
KW  - children
KW  - 1991
KW  - Anxiety Disorders
KW  - Child Attitudes
KW  - Child Psychology
U2  - Klein, Rachel G.; Last, Cynthia G. (1989); Anxiety Disorders in Children; Newbury Park, CA: Sage, 1989. 140 pp. $19.95 hardcover; $12.95 paperback; 0-8039-3220-0 (Hardcover); 0-8039-3221-9 (Paperback).
DO  - 10.1037/030177
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DP  - EBSCOhost
DB  - pvh
ER  - 

TY  - JOUR
AU  - Kaplan, Mark H.
AU  - Hall, William W.
AU  - Susin, Myron
AU  - Pahwa, Savita
AU  - Salahuddin, S. Zaki
AU  - Heilman, Conrad
AU  - Fetten, James
AU  - Coronesi, Maria
AU  - Farber, Bruce F.
AU  - Smith, Sharon
T1  - Syndrome of Severe Skin Disease, Eosinophilia, and Dermatopathic Lymphadenopathy in Patients with HTLV-II Complicating Human Immunodeficiency Virus Infection.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/09//
VL  - 91
IS  - 3
M3  - Article
SP  - 300
EP  - 309
SN  - 00029343
AB  - Studies the syndrome of dermotopathic lymphadenopathy, eosinophilia and severe skin disease in patients with human T-cell leukemia virus type 1 complicating human immunodeficiency virus infection.  Key issues of interest; Analysis of pertinent topics and relevant issues; Implications on medicine.
KW  - HTLV-I infections
KW  - HIV infections
KW  - SKIN diseases
KW  - EOSINOPHILIA
N1  - Accession Number: 10868220; Kaplan, Mark H. 1 Hall, William W. 1 Susin, Myron 2 Pahwa, Savita 3 Salahuddin, S. Zaki 4 Heilman, Conrad 5 Fetten, James 1 Coronesi, Maria 1 Farber, Bruce F. 1 Smith, Sharon 6; Affiliation:  1: Department of Medicine, North Shore University Hospital, Cornell University Medical College, New York  2: Department of Pathology, North Shore University Hospital, Cornell University Medical College, New York  3: Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, New York  4: Laboratory of Tumor and Cell Biology, National Cancer Institute, Maryland  5: E.I. Dupont de Nemours and Company, Delaware  6: Department of Pathology and Medicine, University of Medicine and Dentistry of New Jersey, East Orange Veterans Affairs Medical Center; Source Info: Sep91, Vol. 91 Issue 3, p300; Subject Term: HTLV-I infections; Subject Term: HIV infections; Subject Term: SKIN diseases; Subject Term: EOSINOPHILIA; Number of Pages: 10p; Illustrations: 6 Black and White Photographs, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Straus, Stephen E.
T1  - INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF CHRONIC FATIGUE SYNDROME.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/09//
VL  - 91
IS  - 3
M3  - Letter
SP  - 320
EP  - 320
SN  - 00029343
AB  - Comments on a research article on the intravenous immunoglobulin treatment of chronic fatigue syndrome published in 'The American Journal of Medicine' in 1991.  Confusion regarding the authors' contention that the distribution of changes in physical, immune and psychologic measures prevented significant differences from being demonstrated; Analysis of pertinent topics and relevant issues; Implications on medicine.
KW  - CHRONIC fatigue syndrome -- Treatment
KW  - IMMUNOGLOBULINS -- Therapeutic use
KW  - UNITED States
N1  - Accession Number: 10868227; Straus, Stephen E. 1; Affiliation:  1: National Institute of Allergy and Infectious Diseases, Maryland; Source Info: Sep91, Vol. 91 Issue 3, p320; Subject Term: CHRONIC fatigue syndrome -- Treatment; Subject Term: IMMUNOGLOBULINS -- Therapeutic use; Subject Term: UNITED States; Number of Pages: 4/9p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Hoffman, Gary S.
AU  - Leavitt, Randi Y.
AU  - Fauci, Anthony S.
T1  - The Reply.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/09//
VL  - 91
IS  - 3
M3  - Letter
SP  - 322
EP  - 322
SN  - 00029343
AB  - Presents the authors' reply to a critique of their research article on the use of pulsed cyclophosphamide therapy for treating Wegener's granulomatosis (WG) published in 'The American Journal of Medicine' in 1991.  Key issues of interest; Analysis of pertinent topics and relevant issues; Implications on medicine.
KW  - CHRONIC granulomatous disease -- Treatment
KW  - MEDICINE
KW  - UNITED States
N1  - Accession Number: 10868232; Hoffman, Gary S. 1 Leavitt, Randi Y. 1 Fauci, Anthony S. 1; Affiliation:  1: National Institute of Allergy and Infectious Diseases, Maryland; Source Info: Sep91, Vol. 91 Issue 3, p322; Subject Term: CHRONIC granulomatous disease -- Treatment; Subject Term: MEDICINE; Subject Term: UNITED States; Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kom, Edward L.
AU  - Graubard, Barry I.
T1  - Epidemiologic Studies Utilizing Surveys: Accounting for the Sampling Design.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/09//
VL  - 81
IS  - 9
M3  - Article
SP  - 1166
EP  - 1173
PB  - American Public Health Association
SN  - 00900036
AB  - Background. Since large-scale health surveys usually have complicated sampling schemes, there is often a question as to whether the sampling design must be considered in the analysis of the data. A recent disagreement concerning the analysis of a body iron stores-cancer association found in the first National Health and Nutrition Examination Survey and its follow-up is used to highlight the issues. Methods. We explain and illustrate the importance of two aspects of the sampling design: clustering and weighting of observations. The body iron stores-cancer data are reanalyzed by utilizing or ignoring various aspects of the sampling design. Simple formulas are given to describe how using the sampling design of a survey in the analysis will affect the conclusions of that analysis. Results. The different analyses of the body iron stores-cancer data lead to very different conclusions. Application of the simple formulas suggests that utilization of the sample clustering in the analysis is appropriate, but that a standard utilization of the sample weights leads to an uninformative analysis. The recommended analysis incorporates the sampling weights in a nonstandard way and the sample clustering in the standard way. Conclusions. Which particular aspects of the sampling design to use in the analysis of complex survey data and how to use them depend on certain features of the design. We give some guidelines for when to use the sample clustering and sample weights in the analysis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH surveys
KW  - IRON
KW  - CANCER
KW  - SAMPLING (Process)
KW  - BIOETHICS
KW  - PROFESSIONAL education
KW  - GUIDELINES
KW  - ASBESTOS
KW  - PUBLIC health
KW  - RISK factors
N1  - Accession Number: 9110142368; Kom, Edward L. 1 Graubard, Barry I. 2; Affiliation:  1: Biometric Research Branch, National Cancer Institute  2: Biometry Branch, National Cancer Institute; Source Info: Sep91, Vol. 81 Issue 9, p1166; Subject Term: HEALTH surveys; Subject Term: IRON; Subject Term: CANCER; Subject Term: SAMPLING (Process); Subject Term: BIOETHICS; Subject Term: PROFESSIONAL education; Subject Term: GUIDELINES; Subject Term: ASBESTOS; Subject Term: PUBLIC health; Subject Term: RISK factors; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 10 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104749439
T1  - Cockroaches (Blatta and Periplaneta species) as reservoirs of drug-resistant salmonellas.
AU  - Devi, S J
AU  - Murray, C J
Y1  - 1991/09//
N1  - Accession Number: 104749439. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737. 
KW  - Antibiotics -- Pharmacodynamics
KW  - Cockroaches -- Microbiology
KW  - Public Health
KW  - Salmonella
KW  - Animals
KW  - Bacterial Typing Techniques
KW  - Drug Resistance, Microbial
KW  - Serotyping
SP  - 357
EP  - 361
JO  - Epidemiology & Infection
JF  - Epidemiology & Infection
JA  - EPIDEMIOL INFECT
VL  - 107
IS  - 2
PB  - Cambridge University Press
AB  - A total of 221 cockroaches (Blatta and Periplaneta spp.), collected in hospitals, houses, animal sheds, grocery stores and restaurants, in various parts of South Kanara District, a south-west coastal region of India, were studied bacteriologically for the presence of various salmonellas. Salmonellas were isolated from 4.1% of these cockroaches. Nine strains of salmonellas were recovered, belonging to five serotypes--Salmonella bovismorbificans, S. oslo, S. typhimurium, S. mbandaka and S. braenderup, the former two being the commonest serotypes. All salmonellas were resistant to one or other of 11 antibacterial drugs used in the susceptibility test. Isolation of salmonellas from cockroaches collected from the livestock premises and human dwellings suggested that they may act as significant reservoirs of salmonella in nature. Recovery of serotypes, phage types and R-types that were commonly isolated from humans and animals of this locality, suggested a transmission role for cockroaches. By harbouring potentially pathogenic, drug-resistant salmonellas, these wandering arthropods may pose dangerous infective hazards to humans and animals.
SN  - 0950-2688
AD  - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1936157.
DO  - 10.1017/S0950268800048998
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bachrach, Christine A.
AU  - Baldwin, Wendy
T1  - Abortion Underreporting.
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
Y1  - 1991/09//Sep/Oct91
VL  - 23
IS  - 5
M3  - Article
SP  - 233
EP  - 233
PB  - Guttmacher Institute, Inc.
SN  - 00147354
N1  - Accession Number: 23730078; Bachrach, Christine A. 1 Baldwin, Wendy 1; Affiliation:  1: National Institute of Child Health and Human Development; Source Info: Sep/Oct91, Vol. 23 Issue 5, p233; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 861
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Leukefeld, Carl G.
AU  - Battjes, Robert J.
AU  - Pickens, Roy W.
T1  - AIDS PREVENTION: CRIMINAL JUSTICE INVOLVEMENT OF INTRAVENOUS DRUG ABUSERS ENTERING METHADONE TREATMENT.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1991///Fall91
VL  - 21
IS  - 4
M3  - Article
SP  - 673
EP  - 683
SN  - 00220426
AB  - The criminal justice system provides access to large numbers of intravenous drug abusers (IVDAs) for AIDS prevention activities. Data from a study of IVDAs entering methadone treatment suggest that criminal justice (CJ) involved IVDAs (probation, parole or released on bond) are somewhat more deviant, relative to HIV behaviors, than subjects not CJ involved, but these differences are minimal. This study suggests that CJ involved can be as responsive to AIDS prevention efforts as IVDAs not CJ involved and emphasizes community HIV prevention focused on needle use and sexual behaviors for IVDAs and their sexual partners. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease) -- Prevention
KW  - DRUG abusers
KW  - METHADONE treatment programs
KW  - DRUG abuse -- Treatment
KW  - CRIMINAL justice administration
N1  - Accession Number: 9201131453; Leukefeld, Carl G. 1 Battjes, Robert J. 2 Pickens, Roy W. 3; Affiliation:  1: Director, Center on Drug and Alcohol Abuse Research, University of Kentucky in Lexington, Kentucky  2: Deputy director, Division of Clinical Research, National Institute on Drug Abuse, Rockville, Maryland  3: Director, National Institute on Drug Abuse (NIDA) Addiction Research Center in Baltimore, Maryland; Source Info: Fall91, Vol. 21 Issue 4, p673; Subject Term: AIDS (Disease) -- Prevention; Subject Term: DRUG abusers; Subject Term: METHADONE treatment programs; Subject Term: DRUG abuse -- Treatment; Subject Term: CRIMINAL justice administration; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 11p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 3929
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bernstein, Eric F.
AU  - Harisiadis, Lconidas
AU  - Salomon, Gary
AU  - Norton, Jeffrey
AU  - Sollberg, Stephan
AU  - Uitto, Jouni
AU  - Glatstein, Eli
AU  - Glass, Joseph
AU  - Talbot, Thomas
AU  - Russo, Angelo
AU  - Mitchell, James B.
T1  - Transforming Growth Factor-β Improves healing of Radiation-Impaired Wounds.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/09//
VL  - 97
IS  - 3
M3  - Article
SP  - 430
EP  - 434
SN  - 0022202X
AB  - Exogenously applied TGF-β1 has been shown to increase wound strength in incisional wounds early in the healing process. An impaired wound healing model was first established in guinea pigs by isolating flaps of skin and irradiating the flaps to 15 Gray in one fraction using a 4-MeV linear accelerator. Incisions made 2 d after irradiation were excised 7 d later, and showed decreased linear wound bursting strength (WBS) as compared to non-irradiated control wounds on the contralateral side of each animal (p = 0.001). The effect of TGF-β on healing of radiation-impaired wounds was studied using this model. Skin on both left and right sides of guinea pigs was irradiated as above. A linear incision was made in each side. Collagen with either 1, 5, or 20 μg of TGF-β was applied to one side prior to closure with staples, whereas the contralateral side received saline in collagen. Wounds given either 1 or 5 μg of TGF-β were found to be stronger than controls at 7 d (p < 0.05), whereas those receiving the higher 20-μg dose were weaker than controls (p < 0.05). Thus, TGF-β in lower doses improved healing at 7 d but very large amounts of the growth factor actually impaired healing. In situ hybridization done on wound samples showed increased type I collagen gene expression by fibroblasts in wounds treated with 1 μg TGF-β over control wounds. These results indicate that TGF-β improved wound healing as demonstrated by increased WBS. This improvement is accompanied by an up-regulation of collagen gene expression by resident fibroblasts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GROWTH factors
KW  - RADIATION
KW  - WOUNDS & injuries
KW  - HEALING
KW  - GUINEA pigs
KW  - SKIN
N1  - Accession Number: 12481258; Bernstein, Eric F. 1,2 Harisiadis, Lconidas 1,3 Salomon, Gary 4 Norton, Jeffrey 4 Sollberg, Stephan 5 Uitto, Jouni 5 Glatstein, Eli 1 Glass, Joseph 1 Talbot, Thomas 6 Russo, Angelo 1 Mitchell, James B. 1; Affiliation:  1: Radiation Oncology Branch, National Institutes of Health, Bethesda, Maryland.  2: Hahnemann University Division of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.  3: George Washington University Medical Center, Washington, D.C. U.S.A.  4: Surgery Branch, National Institutes of Health, Bethesda, Maryland.  5: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.  6: BMEIB, National Institutes of Health, Bethesda, Maryland.; Source Info: Sep91, Vol. 97 Issue 3, p430; Subject Term: GROWTH factors; Subject Term: RADIATION; Subject Term: WOUNDS & injuries; Subject Term: HEALING; Subject Term: GUINEA pigs; Subject Term: SKIN; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12481258
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zachariae, Claus O. C.
AU  - Thestrup-Pedersen, Kristian
AU  - Matsushima, Kouji
T1  - Expression and Secretion of Leukocyte Chemotactic Cytokines by Normal Human Melanocytes and Melanoma Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/09//
VL  - 97
IS  - 3
M3  - Article
SP  - 593
EP  - 599
SN  - 0022202X
AB  - The capacity of human melanocytes and melanoma cells to produce IL-8 and monocyte chemotactic and activating factor (MCAF) was investigated. Melanocytes expressed mRNA for IL-8 and MCAF, when stimulated with either IL-1α or TNFα, but not when stimulated with IL-6, IFNγ, or LPS alone. IL-8 and MCAF could be induced in a dose-dependent fashion with doses as low as 0.1 ng/ml TNFα and 0.5 ng/ml IL-1α. IL-8 and MCAF mRNA were rapidly expressed and peaked between 2 and 4 h for IL-8 and between 4 and 8 h for MCAF. This correlated well with the accumulation of IL-8 antigen as measured by a radioimmunoassay. Supernatants from melanocyte cultures stimulated with either IL-1α or TNFα and separated on a heparin-Sepharose column became positive for neutrophil and monocyte chemotactic activity in a dose- and time-dependent fashion. When IFNγ was added to melanocyte cultures stimulated with suboptimal doses of TNFα there was a synergistic increase in secreted IL-8 protein and monocyte chemotactic activity. These data provide further evidence for the possible role of melanocytes in the initiation of an inflammatory reaction. Three different malignant melanoma cell lines stimulated with either TNFα or IL-1α expressed IL-8 mRNA, but not mRNA for MCAF. The IL-8 mRNA signal corresponded well with the amount of secreted IL-8 protein. These data suggest that IL-8 and MCAF may play a role in growth regulation and spreading of melanomas. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUCOCYTES
KW  - CHEMOKINES
KW  - MELANOCYTES
KW  - MELANOMA
KW  - ANTIGENS
KW  - RADIOIMMUNOASSAY
N1  - Accession Number: 12481934; Zachariae, Claus O. C. 1 Thestrup-Pedersen, Kristian 2 Matsushima, Kouji 1; Affiliation:  1: Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland, U.S A.  2: Department of Dermatology, Marselisborg Hospital, Aarhus,Denmark.; Source Info: Sep91, Vol. 97 Issue 3, p593; Subject Term: LEUCOCYTES; Subject Term: CHEMOKINES; Subject Term: MELANOCYTES; Subject Term: MELANOMA; Subject Term: ANTIGENS; Subject Term: RADIOIMMUNOASSAY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12481934
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stone, Arthur A.
AU  - Kessler, Ronald C.
AU  - Haythornthwaite, Jennifer A.
T1  - Measuring Daily Events and Experiences: Decisions for the Researcher.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1991/09//
VL  - 59
IS  - 3
M3  - Article
SP  - 575
EP  - 607
PB  - Wiley-Blackwell
SN  - 00223506
AB  - There has been a burgeoning interest in studying daily events and experiences. This article discusses a variety of methodologic challenges that face daily event and experience researchers. The issues discussed include techniques for measuring events, the development of event checklists, sampling event content, specifying event appraisals, event validation procedures, and the creation of summary measures derived from event checklists. Procedural issues discussed include determining the number of observations and persons needed for daily event studies, the evaluation of response, attrition, and missing item bias, and problems linking event reports over time. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXPERIENCE
KW  - EVERYDAY life
KW  - QUALITY of life
KW  - SAMPLING (Statistics)
KW  - PENANCE
KW  - METHODOLOGY
N1  - Accession Number: 9110141812; Stone, Arthur A. 1 Kessler, Ronald C. 2 Haythornthwaite, Jennifer A. 3; Affiliation:  1: SUNY-Stony Brook  2: University of Michigan  3: National Institute on Aging; Source Info: Sep91, Vol. 59 Issue 3, p575; Subject Term: EXPERIENCE; Subject Term: EVERYDAY life; Subject Term: QUALITY of life; Subject Term: SAMPLING (Statistics); Subject Term: PENANCE; Subject Term: METHODOLOGY; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 33p; Document Type: Article
L3  - 10.1111/1467-6494.ep9110141812
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104744116
T1  - The causes of death in patients with human immunodeficiency virus infection: a clinical and pathologic study with emphasis on the role of pulmonary diseases.
AU  - McKenzie, R
AU  - Travis, W D
AU  - Dolan, S A
AU  - Pittaluga, S
AU  - Feuerstein, I M
AU  - Shelhamer, J
AU  - Yarchoan, R
AU  - Masur, H
Y1  - 1991/09//1991 Sep
N1  - Accession Number: 104744116. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - HIV Infections -- Mortality
KW  - Lung Diseases -- Etiology
KW  - Adolescence
KW  - Adult
KW  - Cause of Death
KW  - Cytomegalovirus Infections -- Etiology
KW  - Female
KW  - HIV Infections -- Complications
KW  - HIV Infections -- Pathology
KW  - Lung Neoplasms -- Etiology
KW  - Male
KW  - Middle Age
KW  - Opportunistic Infections -- Etiology
KW  - Pneumonia, Pneumocystis -- Etiology
KW  - Respiratory Failure -- Etiology
KW  - Sarcoma, Kaposi's -- Etiology
SP  - 326
EP  - 343
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 70
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The clinical records and autopsy data of 75 patients dying with AIDS were reviewed to determine the frequency of individual diseases diagnosed premortem and postmortem, the significance of pulmonary processes found in the lungs at autopsy, and the clinical and pathologic causes of death. Cytomegalovirus (CMV) infection was identified histologically either premortem or postmortem in 81% of patients. The lungs and adrenal glands were infected most commonly. Only one-half of CMV infections were recognized premortem. Pneumocystis pneumonia and Kaposi sarcoma occurred in 68% and 59% of patients, respectively, but were not unsuspected premortem in any patient. Visceral involvement with Kaposi sarcoma, however, was frequently recognized only at autopsy. While disseminated M. avium-intracellulare infection was common (31% of patients), histologically documented pulmonary disease was uncommon (3% of patients). Cryptococcal infection, diagnosed in 10 patients, was confined to the central nervous system in only 1 patient. Toxoplasma, in contrast, infected the brain of only 6 patients. All 75 patients had one or more disease processes identified in their lungs or pleurae at autopsy. These processes included opportunistic infections in 76% of patients, neoplasms in 37% (Kaposi sarcoma in 36% and lymphoma in 3%), and other processes in 60%. The most prevalent pathogen, CMV was found in pulmonary tissue from 44 patients and caused significant disease in 21 patients. Five patients died due to CMV pneumonia. Pneumocystis carinii was found at autopsy in 24 patients. In spite of treatment, pneumocystis pneumonia was fatal in 11 patients. One patient died with concomitant CMV and pneumocystis pneumonia. Kaposi sarcoma, identified in the lungs of 23 patients, led to death in 5 patients via upper airway obstruction, hemorrhage, or parenchymal destruction. Other fatal pulmonary processes included bacterial pneumonia in 9 patients, idiopathic diffuse alveolar damage in 5, cryptococcosis in 2, and pulmonary hemorrhage in 1. Specific clinical criteria were used to determine the cause of death due to organ system failure. Fifty-one percent of patients died due to respiratory failure; 16% from neurologic disease; 17% from hypotension that was not caused by respiratory, neurologic, or cardiac disease; and 3% from cardiac dysfunction. Thirteen percent of deaths did not meet the clinical criteria defining these 4 categories. This clinical assessment was combined with autopsy data to identify specific diseases as causes of death.(ABSTRACT TRUNCATED AT 400 WORDS)
SN  - 0025-7974
AD  - National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1656164.
DO  - 10.1097/00005792-199109000-00004
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104744202
T1  - Abnormal skin temperature and abnormal sympathetic vasomotor innervation in an experimental painful peripheral neuropathy.
AU  - Wakisaka, S
AU  - Kajander, K C
AU  - Bennett, G J
Y1  - 1991/09//1991 Sep
N1  - Accession Number: 104744202. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Muscle, Smooth -- Innervation
KW  - Pain -- Physiopathology
KW  - Peripheral Nervous System Diseases -- Physiopathology
KW  - Skin Temperature -- Physiology
KW  - Sympathetic Nervous System -- Physiopathology
KW  - Animals
KW  - Histocytochemistry
KW  - Male
KW  - Muscle, Smooth -- Pathology
KW  - Muscle, Smooth -- Physiopathology
KW  - Neural Pathways -- Physiology
KW  - Neurons -- Physiology
KW  - Norepinephrine -- Metabolism
KW  - Pain -- Pathology
KW  - Peripheral Nervous System Diseases -- Pathology
KW  - Rats
KW  - Sciatic Nerve -- Injuries
KW  - Sympathetic Nervous System -- Pathology
KW  - Vasoconstriction -- Physiology
SP  - 299
EP  - 313
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 46
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1661885.
DO  - 10.1016/0304-3959(91)90113-C
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Breen, Nancy
AD  - National Cancer Institute
T1  - The Origins of Modern American Feminism: Review Article
JO  - Review of Radical Political Economics
JF  - Review of Radical Political Economics
Y1  - 1991///Fall-Winter 1991
VL  - 23
IS  - 3-4
SP  - 306
EP  - 313
SN  - 04866134
N1  - Accession Number: 0271446; Keywords: Feminism; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199212
KW  - Economics of Gender; Non-labor Discrimination          J16
KW  - Economic History: Labor and Consumers, Demography, Education, Health, Welfare, Income, Wealth, Religion, and Philanthropy: Europe: Pre-1913          N33
L3  - http://rrp.sagepub.com/content/by/year
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DP  - EBSCOhost
DB  - ecn
ER  - 
TY  - JOUR
AU  - Wiener, Lori S.
T1  - Women and Human Immunodeficiency Virus: A Historical and Personal Psychosocial Perspective.
JO  - Social Work
JF  - Social Work
Y1  - 1991/09//
VL  - 36
IS  - 5
M3  - Article
SP  - 375
EP  - 378
PB  - Oxford University Press / USA
SN  - 00378046
AB  - This article focuses on psychosocial aspects of human immunodeficiency virus (HIV) diseases in women, specially in the U.S., from both historical and personal perspectives, illustrating several concerned research and development works. The author comments on the comparatively less attention paid in clinical practice, research or public discussion to women's role in the AIDS epidemic. She refers some of the research volumes that chronicled a community response to AIDS but omitted the enormous investment of time, energy, support, and love provided by women throughout the epidemic. Some of volumes kept under this category are: "And the Band Played On," by R. Shilts; "Early Frost," by J. Sherman; and "Normal Heart," by L. Kramer. The author discusses the issue by citing an emotional story of a HIV infected mother, named Mary, and her daughter, named Mara. Researchers K. Anastos and C. Marte, reportedly, have described how deeply ingrained societal sexism, racism, and classism have greatly affected the public perception of HIV infection and AIDS in women throughout the 1980s and into the 1990s. According to several researches, for HIV-infected women, stigma and discrimination are intensified. The most highly represented populations of infected women are intravenous drug users and nonwhite women.
KW  - AIDS (Disease) in women
KW  - WOMEN -- Health
KW  - WOMEN -- United States
KW  - SOCIAL perception
KW  - SEXISM
KW  - RACE awareness
KW  - CLINICAL sociology
KW  - EPIDEMIOLOGY -- Research
KW  - UNITED States
N1  - Accession Number: 9111183686; Wiener, Lori S. 1; Affiliation:  1: Pediatric HIV Psychosocial Support Program, Pediatric Branch, National Institutes of Health, Building 10, Room 13N240, Bethesda, MD 20892.; Source Info: Sep91, Vol. 36 Issue 5, p375; Subject Term: AIDS (Disease) in women; Subject Term: WOMEN -- Health; Subject Term: WOMEN -- United States; Subject Term: SOCIAL perception; Subject Term: SEXISM; Subject Term: RACE awareness; Subject Term: CLINICAL sociology; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Su, Tsung-Ping
T1  - σ receptors.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/09/15/
VL  - 200
IS  - 3
M3  - Article
SP  - 633
EP  - 642
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The σ receptor is a neuronal substrate that binds several psychoactive compounds. These include cocaine, some steroids, dextromethorphan, phencyclidine (PCP), and benzomorphans such as pentazocine and N-allyl- normatezocine (SK F-10047). Many newer atypical antipsychotic drugs also bind to the σ receptor. The σ receptor, however, is not the PCP receptor. The σ receptor exists in the central nervous system, endocrine, immune and certain peripheral tissues. Progesterone and certain steroids have been shown to represent endogenous ligands for the σ receptor. The σ receptor resides likely in the nonsynaptic region of the plasma membrane. The σ receptor exists in two forms: high-affinity and low-affinity. The solubilized σ receptor retains all of the pharmacological characteristics of a membrane-bound receptor. A major physiological role of the σ receptor may involve the modulation of a tonic potassium channel. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSYCHIATRIC drugs
KW  - IMMUNE system
KW  - CELL membranes
KW  - STEROIDS
KW  - PROGESTERONE
KW  - NEUROSCIENCES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13699669; Su, Tsung-Ping 1; Affiliation:  1: Neurochemistry Unit, Neuropharmacology Laboratory, National Institute on Drug Abuse, Addiction Research Center, Baltimore, USA; Source Info: 9/15/91, Vol. 200 Issue 3, p633; Subject Term: PSYCHIATRIC drugs; Subject Term: IMMUNE system; Subject Term: CELL membranes; Subject Term: STEROIDS; Subject Term: PROGESTERONE; Subject Term: NEUROSCIENCES; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Henderson, David K.
T1  - Postexposure Chemoprophylaxis for Occupational Exposure to Human Immunodeficiency Virus Type 1: Current Status and Prospects for the Future.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/09/16/
VL  - 91
IS  - 3B
M3  - Article
SP  - 312S
EP  - 319S
SN  - 00029343
AB  - Examines available data regarding postexposure chemoprophylaxis.  Possible sites of action for a candidate chemoprophylactic agent; Properties of an ideal chemoprophylactic agent; Assessment of zidovudine as a candidate for postexposure chemoprophylaxis; Clinical experience with zidovudine; Barriers to effective chemoprophylaxis.
KW  - CHEMOPREVENTION
KW  - PREVENTIVE medicine
KW  - AZT (Drug)
KW  - INFECTION -- Prevention
N1  - Accession Number: 10939527; Henderson, David K. 1; Affiliation:  1: Warren G. Magnuson Clinical Center, National Institutes of Health, Maryland; Source Info: 9/16/91, Vol. 91 Issue 3B, p312S; Subject Term: CHEMOPREVENTION; Subject Term: PREVENTIVE medicine; Subject Term: AZT (Drug); Subject Term: INFECTION -- Prevention; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Keiser, Harry R.
AU  - Keiser, H R
T1  - Surreptitious self-administration of epinephrine resulting in 'pheochromocytoma'.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/09/18/
VL  - 266
IS  - 11
M3  - journal article
SP  - 1553
EP  - 1555
SN  - 00987484
AB  - Presents the case of a woman with a possible pheochromocytoma.  Symptoms presented by the patient; Treatment received; Result of the patient's clonidine suppression test; Causes and prognosis of pheochromocytoma.
KW  - PHEOCHROMOCYTOMA
KW  - NEUROENDOCRINE tumors
KW  - CLONIDINE
KW  - ANTIHYPERTENSIVE agents
KW  - DIAGNOSIS
KW  - PROGNOSIS
KW  - FACTITIOUS disorders
KW  - ADRENAL tumors
KW  - MUNCHAUSEN syndrome
KW  - ADRENALINE
KW  - COMPUTED tomography
KW  - SELF medication
KW  - PSYCHOLOGICAL aspects
N1  - Accession Number: 10485432; Keiser, Harry R. Keiser, H R 1; Affiliation:  1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 9/18/91, Vol. 266 Issue 11, p1553; Subject Term: PHEOCHROMOCYTOMA; Subject Term: NEUROENDOCRINE tumors; Subject Term: CLONIDINE; Subject Term: ANTIHYPERTENSIVE agents; Subject Term: DIAGNOSIS; Subject Term: PROGNOSIS; Subject Term: FACTITIOUS disorders; Subject Term: ADRENAL tumors; Subject Term: MUNCHAUSEN syndrome; Subject Term: ADRENALINE; Subject Term: COMPUTED tomography; Subject Term: SELF medication; Subject Term: PSYCHOLOGICAL aspects; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Crystal, Ronald G.
T1  - Introduction.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/09/30/
VL  - 91
IS  - 3C
M3  - Article
SP  - 1S
EP  - 1S
SN  - 00029343
AB  - Introduces articles about antioxidants and oxidants published in the September 30, 1991 issue of the periodical 'American Journal of Medicine.'  Highlights of a symposium on the issue; Explanation of topics of interests.
KW  - ANTIOXIDANTS
KW  - OXIDIZING agents
KW  - PERIODICAL publishing
N1  - Accession Number: 10867383; Crystal, Ronald G. 1; Affiliation:  1: Pulmonary Branch, National Heart, Lung, and Blood Institute; Source Info: 9/30/91, Vol. 91 Issue 3C, p1S; Subject Term: ANTIOXIDANTS; Subject Term: OXIDIZING agents; Subject Term: PERIODICAL publishing; NAICS/Industry Codes: 511120 Periodical Publishers; Number of Pages: 1p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Crystal, Ronald G.
T1  - Oxidants and Respiratory Tract Epithelial Injury: Pathogenesis and Strategies for Therapeutic Intervention.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/09/30/
VL  - 91
IS  - 3C
M3  - Article
SP  - 39S
EP  - 44S
SN  - 00029343
AB  - Focuses on the role of oxidants in mediating respiratory epithelial cell injury.  Significance for understanding oxidants' role in pathogenic mechanism of many lung diseases; Details of the oxidant burden of the normal respiratory epithelium.
KW  - RESPIRATORY infections
KW  - EPITHELIAL cells
KW  - OXIDIZING agents
N1  - Accession Number: 10867388; Crystal, Ronald G. 1; Affiliation:  1: National Heart, Lung, and Blood Institute; Source Info: 9/30/91, Vol. 91 Issue 3C, p39S; Subject Term: RESPIRATORY infections; Subject Term: EPITHELIAL cells; Subject Term: OXIDIZING agents; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Messina, Mark
T1  - Phytate's potential role in reducing colon-cancer risk.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1991/10//
VL  - 54
IS  - 4
M3  - Article
SP  - 762
EP  - 763
SN  - 00029165
N1  - Accession Number: 95888702; Messina, Mark 1; Affiliations: 1: Diet and Cancer Branch, Division of Cancer Prevention and Control, Executive Plaza North, Room 212C, National Cancer Institute, Bethesda, MD 20892; Issue Info: Oct1991, Vol. 54 Issue 4, p762; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hibbs, Jonathan R.
AU  - Gunn, Robert A.
T1  - Public Health Intervention in a Cocaine-Related Syphilis Outbreak.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/10//
VL  - 81
IS  - 10
M3  - Article
SP  - 1259
EP  - 1262
PB  - American Public Health Association
SN  - 00900036
AB  - Background. Cocaine users and prostitutes are at high risk for syphilis, but disease control is difficult among these populations. During a cocaine-related syphilis outbreak in Chester, Pennsylvania, in 1989, we conducted a control program at sites where sex and drugs were sold. Methods. During a 2-week period, investigators recruited persons from these sites for interview, serologic testing, and empiric treatment. Results. Among 136 persons screened, 25 (18%) had early syphilis and 26 others (19%) had recent sexual contact with early syphilis patients. All were treated at initial screening at a cost of $402 and 12 investigator hours per case, compared to $470 and 20 hours per case when treated during routine investigator activities. This program may have contributed to a short-term decline in syphilis incidence in Chester by reducing the period of infectivity of these patients. Conclusions. Screening and empiric treatment of persons at sites where sex and drugs are sold can be useful in short-term control of cocaine-related syphilis outbreaks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abusers
KW  - PROSTITUTES
KW  - COCAINE
KW  - SYPHILIS
KW  - MEDICAL screening
KW  - DRUGS & sex
KW  - CHESTER (Pa.)
KW  - PENNSYLVANIA
N1  - Accession Number: 9112090806; Hibbs, Jonathan R. 1 Gunn, Robert A. 2; Affiliation:  1: National Institutes of Health in Bethesda, Md.  2: Epidemiology Program Office of the Centers for Disease Control, Atlanta, Ga.; Source Info: Oct91, Vol. 81 Issue 10, p1259; Subject Term: DRUG abusers; Subject Term: PROSTITUTES; Subject Term: COCAINE; Subject Term: SYPHILIS; Subject Term: MEDICAL screening; Subject Term: DRUGS & sex; Subject Term: CHESTER (Pa.); Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 4p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Bickell, Nina A.
AU  - Vermund, Sten H.
AU  - Holmes, Michelle
AU  - Safyer, Steven
AU  - Burk, Robert D.
T1  - Human Papillomavirus, Gonorrhea, Syphilis, and Cervical Dysplasia in Jailed Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1991/10//
VL  - 81
IS  - 10
M3  - Article
SP  - 1318
EP  - 1320
PB  - American Public Health Association
SN  - 00900036
AB  - We assessed the prevalence of human papillomavirus (HPV) by cervicovaginal lavage and Southern blot and inquired about behavioral risk factors for cervical disease and sexually transmitted diseases by interview in 114 female detainees at a large New York City jail. Of the women screened, 8% had abnormal Pap smears, 35% had HPV, 7% had gonorrhea, and 22% had serologic syphilis. Given the high rates of HPV infection and cervical cytology, Pap smears should be a routine intake procedure for incarcerated women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PAPILLOMAVIRUSES
KW  - IRRIGATION (Medicine)
KW  - CERVIX uteri -- Diseases
KW  - SEXUALLY transmitted diseases
KW  - WOMEN prisoners
KW  - PAPILLOMAVIRUS diseases
KW  - PAP test
N1  - Accession Number: 9112090821; Bickell, Nina A. 1 Vermund, Sten H. 2 Holmes, Michelle 3 Safyer, Steven 4,5 Burk, Robert D. 5,6; Affiliation:  1: Department of Medicine, Gouverneur Hospital, NY  2: National Institutes of Health, Bethesda, Md.  3: Cambridge Hospital, Mass.  4: Montefiore-Rikers Island Health Service, Bronx, NY  5: Montefiore Medical Center, Bronx, NY  6: Albert Einstein College of Medicine, Bronx, NY; Source Info: Oct91, Vol. 81 Issue 10, p1318; Subject Term: PAPILLOMAVIRUSES; Subject Term: IRRIGATION (Medicine); Subject Term: CERVIX uteri -- Diseases; Subject Term: SEXUALLY transmitted diseases; Subject Term: WOMEN prisoners; Subject Term: PAPILLOMAVIRUS diseases; Subject Term: PAP test; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Birch, Nigel P.
AU  - Bennett, Hugh P. J.
AU  - Estivariz, Fernando E.
AU  - Loh, Y. Peng
T1  - Effect of calcium ions on the processing of pro-opiomelanocortin by bovine intermediate lobe pro-opiomelanocortin-converting enzyme.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1991/10//10/1/91
VL  - 201
IS  - 1
M3  - Article
SP  - 85
EP  - 89
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The effect of Ca2+ on the extent and pattern of processing of pro-opiomelanocortin and an N-terminal fragment by a purified pituitary secretory vesicle, soluble aspartic endoprotease, was studied. Ca2+ stimulated the first cleavage of pro-opiomelanocortin by pro-opiomelanocortin-converting enzyme to yield 21–23 kDa adrenocorticotropin and β-lipotropin, but its effect was minimal. The production of adrenocorticotropin from the 21–23 kDa intermediate was stimulated approximately 2.3-fold in the presence of 10 mM Ca2+, and processing of β-lipotropin to β-endorphin was stimulated about 1.3–1.4-fold by 5–10 mM Ca2+. The production of γ-melanotropin-immunoreactive material from bovine N-pro-opiomelanocortin(1–77) was stimulated approximately 1.3-fold at both 100 μM and 1.5–2.0 mM Ca2+. Further characterization of the γ-melanotropin-immunoreactive material by HPLC demonstrated that the major products were γ3-[Lys]melanotropin and γ3-melanotropin at both Ca2+ concentrations. These results indicate that pro-opiomelanocortin-converting enzyme is stimulated by Ca2+. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALCIUM ions
KW  - ENZYMES
KW  - LIPOTROPIN
KW  - ENDORPHINS
KW  - MSH (Hormone)
KW  - PROTEOLYTIC enzymes
N1  - Accession Number: 13726440; Birch, Nigel P. 1 Bennett, Hugh P. J. 2 Estivariz, Fernando E. 1 Loh, Y. Peng 1; Affiliation:  1: Section on Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA  2: Royal Victoria Hospital, Montreal, Canada; Source Info: 10/1/91, Vol. 201 Issue 1, p85; Subject Term: CALCIUM ions; Subject Term: ENZYMES; Subject Term: LIPOTROPIN; Subject Term: ENDORPHINS; Subject Term: MSH (Hormone); Subject Term: PROTEOLYTIC enzymes; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ketterlinus, Robert D.
AU  - Lamb, Michael E.
AU  - Nitz, Katherine
T1  - Developmental and Ecological Sources of Stress Among Adolescent Parents.
JO  - Family Relations
JF  - Family Relations
Y1  - 1991/10//
VL  - 40
IS  - 4
M3  - Article
SP  - 435
EP  - 441
SN  - 01976664
AB  - This article provides an overview of research on the stresses associated with normative developmental transitions, the effects of psychological stress on adult parenting and parent-child interactions, and the stresses associated with the transition to parenthood during adolescence, with an emphasis on school-age parents. Suggestions are provided for the design of developmentally and ecologically valid research and interventions, and for broadly based public policy addressing the unique problems associated with adolescent parenting. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Family Relations is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TEENAGE parents
KW  - PARENT & child
KW  - FAMILY communication
KW  - CHILD rearing
KW  - CHILD care
KW  - CHILDREN of teenage mothers
KW  - FAMILIES -- Study & teaching
KW  - INTERPERSONAL relations
KW  - STRESS (Psychology)
KW  - adolescent parents
KW  - interventions
KW  - public policy
KW  - review
KW  - stress
N1  - Accession Number: 9112090310; Ketterlinus, Robert D. 1 Lamb, Michael E. 2 Nitz, Katherine 3; Affiliation:  1: Staff Fellow, Section on Social and Emotional Development (SSED), National Institute of Child Health and Human Development (NICHD), 9190 Rockville Pike, BSA Building, Rm# 331, Bethesda, MD 20814.  2: Senior Research Scientist and Chief of SSED, NICHD.  3: George Washington University, Department of Psychology, Washington, DC.; Source Info: Oct91, Vol. 40 Issue 4, p435; Subject Term: TEENAGE parents; Subject Term: PARENT & child; Subject Term: FAMILY communication; Subject Term: CHILD rearing; Subject Term: CHILD care; Subject Term: CHILDREN of teenage mothers; Subject Term: FAMILIES -- Study & teaching; Subject Term: INTERPERSONAL relations; Subject Term: STRESS (Psychology); Author-Supplied Keyword: adolescent parents; Author-Supplied Keyword: interventions; Author-Supplied Keyword: public policy; Author-Supplied Keyword: review; Author-Supplied Keyword: stress; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 7971
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lal, R. B.
AU  - Dhawan, R. R.
AU  - Tarrand, J. J.
AU  - Ayoubt, E. M.
AU  - Ottesen, E. A.
T1  - Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.
JO  - Immunology
JF  - Immunology
Y1  - 1991/10//
VL  - 74
IS  - 2
M3  - Article
SP  - 333
EP  - 337
PB  - Wiley-Blackwell
SN  - 00192805
AB  - It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were round to be significantly higher in the filariasis patients compared to normals (P<0·01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, lgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P < 0·001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial belminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULIN G
KW  - IMMUNE response
KW  - ANTIGENS
KW  - FILARIASIS
KW  - IMMUNITY
KW  - IMMUNOLOGY
N1  - Accession Number: 14072581; Lal, R. B. 1 Dhawan, R. R. 2 Tarrand, J. J. 2 Ayoubt, E. M. 3 Ottesen, E. A. 4; Affiliation:  1: Division of Tropical Public Health, Uniformed Services University of Health Services, Bethesda, Maryland  2: Division of Laboratory Medicine, M.D. Anderson Cancer Center, Houston, Texas  3: Department of Pediatrics University of Florida, Gainesville, Florida  4: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct91, Vol. 74 Issue 2, p333; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: FILARIASIS; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cooper, James K.
AU  - Mungas, Dan
AU  - Verma, Maxine
AU  - Weiler, Philip G.
T1  - PSYCHOTIC SYMPTOMS IN ALZHEIMER'S DISEASE.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1991/10//
VL  - 6
IS  - 10
M3  - Article
SP  - 721
EP  - 726
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - Memory loss is the hallmark of Alzheimerߣ disease. However, psychotic symptoms have also been reported. We studied the prevalence of hallucinations and delusions in 677 subjects with probable Alzheimerߣs disease. Data were collected in six centers and analyzed retrospectively. A two-stage, multivariate approach was studied. The overall prevalence of these psychotic symptoms was 31%. The prevalence of hallucinations was 17%, and of delusions 26%. Both were associated with emotional incontinence, insomnia and agitation as well as with advanced disease. While psychotic symptoms were more prevalent in advanced disease, nonetheless they occurred with notable frequency in early disease. Of subjects with early AD (MMSE scores between 21 and 30), 6% had hallucinations and 17% had delusions. Alzheimerߣs disease must be considered in the differential diagnosis of any subject over 55 presenting with these psychotic symptoms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALZHEIMER'S disease
KW  - HALLUCINATIONS & illusions
KW  - DELUSIONS
KW  - PSYCHOSES
KW  - SYMPTOMS
KW  - alzheimer&#2019
KW  - delusions
KW  - hallucinations
KW  - LIFE CYCLES: ADULTHOOD, AGING, AND THE FAMILY
KW  - psychotic symptoms
KW  - s disease
N1  - Accession Number: 12104296; Cooper, James K. 1 Mungas, Dan 2 Verma, Maxine 3 Weiler, Philip G. 4; Affiliation:  1: Section Director, Geriatrics Program, National Institute on Aging, Bethesda, USA  2: Associated Director for Research, Alzheimers Disease Diagnosis and Treatment Center, Sacramento, USA  3: Clinical Coordinator, ADDTC, Sacramento, USA  4: Director, ADDTC, Sacramento, USA; Source Info: Oct1991, Vol. 6 Issue 10, p721; Subject Term: ALZHEIMER'S disease; Subject Term: HALLUCINATIONS & illusions; Subject Term: DELUSIONS; Subject Term: PSYCHOSES; Subject Term: SYMPTOMS; Author-Supplied Keyword: alzheimer&#2019; Author-Supplied Keyword: delusions; Author-Supplied Keyword: hallucinations; Author-Supplied Keyword: LIFE CYCLES: ADULTHOOD, AGING, AND THE FAMILY; Author-Supplied Keyword: psychotic symptoms; Author-Supplied Keyword: s disease; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Falanga, Vincent
AU  - Su Wen Qian, Vincent
AU  - Danielpour, David
AU  - Katz, Matthew H.
AU  - Roberts, Anita B.
AU  - Sporn, Michael B.
T1  - Hypoxia Upregulates the Synthesis of TGF-β1 by Human Dermal Fibroblasts.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1991/10//
VL  - 97
IS  - 4
M3  - Article
SP  - 634
EP  - 637
SN  - 0022202X
AB  - In this report, we have investigated the secretion and synthesis of transforming growth factor-β1 (TGF--β1) by human dermal fibroblast cultures β1) response to hypoxia (2% oxygen), and have compared it to standard oxygen culture condition (15% oxygen at the cell surface). Sandwich enzyme-linked immunosorbent assay (SELISA) showed a selective and progressive increase in secretion of the TGF-β1 isoform in response to hypoxia, up to ninefold after cultures were exposed to low oxygen for 72 h; TGF-β2 peptide levels were not increased. We then investigated the transcriptional regulation of the TGF-β1 gene in response to low and standard oxygen tensions. In the first 24--48 h TGF-β1 mRNA levels decreased steadily in both oxygen environments. This mRNA decline continued for up to 72 h in standard oxygen but not in cultures exposed to low oxygen tension. At 72 h, steady-state TGF-β1 mRNA levels were 8 times greater in low compared to standard oxygen, and this increase was reversible upon re-exposure of fibroblast cultures to standard oxygen tension for 24 h. Elevated TGF-β1 mRNA levels in both low and standard oxygen declined steadily and with the same half-life after the addition of actinomycin D, suggesting that hypoxia increased TGF-β1 transcription rather than mRNA stability. We conclude that low oxygen tension upregulates the synthesis of TGF-β1 by human dermal fibroblasts, and leads to increased secretion of this peptide. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANOXEMIA
KW  - FIBROBLASTS
KW  - TRANSFORMING growth factors-beta
KW  - ENZYME-linked immunosorbent assay
KW  - MESSENGER RNA
KW  - PEPTIDES
N1  - Accession Number: 12483126; Falanga, Vincent 1 Su Wen Qian, Vincent 2 Danielpour, David 2 Katz, Matthew H. 1 Roberts, Anita B. 2 Sporn, Michael B. 2; Affiliation:  1: University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, Miami, Florida.  2: National Institutes of Health, National Cancer Institute, Laboratory of Chemoprevention, Bethesda, Maryland, U.S.A..; Source Info: Oct91, Vol. 97 Issue 4, p634; Subject Term: ANOXEMIA; Subject Term: FIBROBLASTS; Subject Term: TRANSFORMING growth factors-beta; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: MESSENGER RNA; Subject Term: PEPTIDES; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12483126
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Belland, R. J.
T1  - H-DNA formation by the coding repeat elements of neisserial opa genes.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/10//
VL  - 5
IS  - 10
M3  - Article
SP  - 2351
EP  - 2360
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The coding repeat region of opa genes from Neisseria gonorrhoeae and Neisseria meningitidis determines the expression state of their respective genes through high-frequency addition or deletion of pentanucleotide ceding repeat units (CRs; CTTCT). <em>In vitro</em> analyses of cloned opa gene CR regions using single-strand specific nucleases, oligonucleotide protection experiments, and modifications of non-B-DNA residues indicate that the regions form structures resembling H-DNA under acidic conditions in the presence of negative supercoiling. The purine/pyrimidine strand bias and H-palindromic nature of the repeat region are consistent with sequence requirements for H-DNA formation. Sequences flanking the repeat elements are required to form the H-DNA structure in vitro as judged by the pattern of exposed non-B-DNA residues in CR sequences synthesized as oligonucleotides to form β-galectosidase::CR translational fusions. The fusions phase vary by addition and deletion of CR elements and the rate of phase variation increases upon induction of the fusion genes. The opa gene CR region is the first reported bacterial H-DNA structure and is unique in that it lies within the ceding sequence for the gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Neisseria gonorrhoeae
KW  - Neisseria meningitidis
KW  - Gene expression
KW  - Oligonucleotides
KW  - Nucleotide sequence
KW  - Genes
KW  - DNA
N1  - Accession Number: 16069891; Belland, R. J. 1; Affiliations: 1: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA; Issue Info: Oct1991, Vol. 5 Issue 10, p2351; Subject Term: Neisseria gonorrhoeae; Subject Term: Neisseria meningitidis; Subject Term: Gene expression; Subject Term: Oligonucleotides; Subject Term: Nucleotide sequence; Subject Term: Genes; Subject Term: DNA; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 10p; Illustrations: 6 Diagrams, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Roger K. Khouri
AU  - Koudsi, Basem
AU  - Reddi, Hari
T1  - Tissue Transformation Into Bone In Vivo.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/10/09/
VL  - 266
IS  - 14
M3  - Article
SP  - 1953
EP  - 1955
SN  - 00987484
AB  - Investigates the possibility of transforming readily available muscle flaps into vascularized bone grafts of various shapes that could be used as skeletal replacement parts.  Osteoinductive factors capable of differentiating mesenchymal tissue into bone; Phenomenon of osteoinduction; Subcutaneous implantation of demineralized bone matrix; Bone morphogenic protein.
KW  - SURGICAL flaps
KW  - MUSCLES
KW  - BONE morphogenetic proteins
N1  - Accession Number: 11019921; Roger K. Khouri 1 Koudsi, Basem 2 Reddi, Hari 3; Affiliation:  1: Department of Surgery, Division of Plastic Surgery, Washington University School of Medicine  2: Plastic Surgery Research Laboratory, Washington University School of Medicine, St. Louis, Missouri  3: Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland; Source Info: 10/9/91, Vol. 266 Issue 14, p1953; Subject Term: SURGICAL flaps; Subject Term: MUSCLES; Subject Term: BONE morphogenetic proteins; Number of Pages: 3p; Illustrations: 3 Black and White Photographs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schneider, Mary L.
AU  - Moore, Colleen F.
AU  - Suomi, Stephen J.
AU  - Champoux, Maribeth
T1  - Laboratory Assessment of Temperament and Environmental Enrichment in Rhesus Monkey Infants (Macaca mulatta).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1991/11//
VL  - 25
IS  - 3
M3  - Article
SP  - 137
EP  - 155
SN  - 02752565
AB  - This study investigated the combined effects of early temperamental characteristics and environmental enrichment on a variety of developmental measures in nursery-reared rhesus monkey infants. Twenty-three infants, reared in either standard laboratory cages or enriched environments, were tested during the 1st month of life for interactive, motor, and temperamental capabilities and characteristics. At 18 months of age, all subjects were assessed on a second series of tests designed to measure their problem-solving skills, motor capabilities, and temperamental responses under challenge. Results indicated that enrichment was associated with higher scores on subsequent problem-solving and motor tests. However, such effects were found to combine with early temperament ratings. Specifically, individuals performing best on the 8-month tests had not only been reared in enriched environments, but also had been rated low on fearfulness during the early assessment. In addition, individuals scoring poorest had been rated as fearful initially in addition to being reared without enrichment. Results indicated that while high ratings on early laboratory assessments of fearfulness may be predictive of poorer problem-solving performance under challenging conditions, these adverse effects may be partially attenuated by environmental enrichment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TEMPERAMENT
KW  - ENVIRONMENTAL enrichment (Animal culture)
KW  - RHESUS monkey
KW  - ANIMAL young
KW  - PROBLEM solving
KW  - MOTOR ability
KW  - ANIMAL behavior
N1  - Accession Number: 12292165; Schneider, Mary L. 1 Moore, Colleen F. 1 Suomi, Stephen J. 2 Champoux, Maribeth 2; Affiliation:  1: University of Wisconsin-Madison  2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Maryland; Source Info: 1991, Vol. 25 Issue 3, p137; Subject Term: TEMPERAMENT; Subject Term: ENVIRONMENTAL enrichment (Animal culture); Subject Term: RHESUS monkey; Subject Term: ANIMAL young; Subject Term: PROBLEM solving; Subject Term: MOTOR ability; Subject Term: ANIMAL behavior; Number of Pages: 19p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson, Elizabeth O.
AU  - Kamilaris, Themis C.
AU  - Carter, Sue
AU  - Gold, Philip W.
AU  - Chrousos, George P.
T1  - "Environmental Stress" and Reproductive Success in the Common Marmoset (Callithrix jacchus jacchus).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1991/11//
VL  - 25
IS  - 3
M3  - Article
SP  - 191
EP  - 201
SN  - 02752565
AB  - The present report documents the breeding success of a new colony of common marmosets (Callithrix jacchus jacchus) and demonstrates a correlation between environmental stress and reproductive success. Environmental conditions ranged chronologically over 40 months, through four periods: I) the initial period, when the colony was formed; II) a phase of relative environmental stability; III) a stage of "environmental stress" (when the colony was disrupted by nearby construction); and IV) a return to a stable environment. Examination of reproductive status during each period indicated that the colony exhibited severe reproductive suppression during the time of the environmental disruption. Parity and the number of live births decreased and the number of spontaneous abortions increased during this period. Reproductive success remained low during period IV. More triplets than twins were born during the period of relative environmental stability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STRESS (Physiology)
KW  - ACCLIMATIZATION
KW  - MARMOSETS
KW  - REPRODUCTION
KW  - COLONIES (Biology)
KW  - ANIMAL behavior
N1  - Accession Number: 12292259; Johnson, Elizabeth O. 1,2,3 Kamilaris, Themis C. 1,2 Carter, Sue 3 Gold, Philip W. 2 Chrousos, George P. 1; Affiliation:  1: Developmental Endocrinology Branch, National Institute of Child Health and Human Development  2: Clinical Neuroendocrinology Branch, National Institute of Mental Health, NIH, Maryland  3: Department of Zoology, the University of Maryland; Source Info: 1991, Vol. 25 Issue 3, p191; Subject Term: STRESS (Physiology); Subject Term: ACCLIMATIZATION; Subject Term: MARMOSETS; Subject Term: REPRODUCTION; Subject Term: COLONIES (Biology); Subject Term: ANIMAL behavior; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - amp-46-11-1112
AN  - amp-46-11-1112
AU  - Jones, James M.
AU  - Levine, Irene S.
AU  - Rosenberg, Allison A.
T1  - Acknowledgments
T3  - Homelessness
JF  - American Psychologist
JO  - American Psychologist
Y1  - 1991/11//
VL  - 46
IS  - 11
SP  - 1112
EP  - 1112
PB  - American Psychological Association
SN  - 0003-066X
SN  - 1935-990X
N1  - Accession Number: amp-46-11-1112. Partial author list: First Author & Affiliation: Jones, James M.; American Psychological Association. Publication Type: Journal (0100). Document Type: Additional Content. Language: English. Page Count: 1. 
KW  - 1991
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DP  - EBSCOhost
DB  - pdh
ER  - 

TY  - JOUR
AU  - Shindo, Michiko
AU  - Di Bisceglie, Adrian M.
AU  - Ling Cheung
AU  - Wai-Kuo Shih, J.
AU  - Cristiano, Karen
AU  - Feinstone, Stephen M.
AU  - Hoofnagle, Jay H.
AU  - Shindo, M
AU  - Di Bisceglie, A M
AU  - Cheung, L
AU  - Shih, J W
AU  - Cristiano, K
AU  - Feinstone, S M
AU  - Hoofnagle, J H
T1  - Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1991/11//11/1/91
VL  - 115
IS  - 9
M3  - journal article
SP  - 700
EP  - 704
SN  - 00034819
AB  - <bold>Objective: </bold>To assess the effect of alpha-interferon therapy on hepatitis C viral RNA in serum of patients with chronic hepatitis C.<bold>Design: </bold>Retrospective testing for hepatitis C viral (HCV) RNA and antibody to the hepatitis C virus (anti-HCV) of stored serum samples from a randomized, double-blind, placebo-controlled trial of alpha-interferon therapy.<bold>Setting: </bold>Warren Grant Magnuson Clinical Center of the National Institutes of Health, a tertiary referral center.<bold>Patients: </bold>Forty-one patients with chronic non-A, non-B hepatitis were entered in this trial.<bold>Interventions: </bold>Twenty-one patients were treated with alpha-interferon, and 20 patients were treated with placebo for 6 months. Seventeen placebo recipients were then treated with alpha-interferon for up to 1 year.<bold>Methods: </bold>Samples were tested for anti-HCV by enzyme-linked immunosorbent assay. Hepatitis C viral RNA was detected in serum using the polymerase chain reaction. Titers of both antibody and RNA were determined by serial end-point dilution.<bold>Main Results: </bold>At entry into the trial, 37 (90%) of 41 patients had anti-HCV and 39 (95%) had HCV RNA in serum. Anti-HCV titers decreased slightly with treatment. Serum levels of HCV RNA decreased in all patients who responded to alpha-interferon therapy with improvements in serum aminotransferases; in 17 of 21 responders (81%; 95% Cl, 58% to 95%) HCV RNA became undetectable. In contrast, in only 2 of 16 (12%; Cl, 2% to 38%) patients who did not respond to treatment did HCV RNA become undetectable. In 19 patients treated during the preliminary 6-month period with placebo, HCV RNA remained detectable. Finally, in the 11 patients who relapsed when treatment was stopped, HCV RNA reappeared in the serum, but in 4 of 7 patients with a sustained improvement in serum aminotransferases, HCV RNA remained undetectable.<bold>Conclusions: </bold>These results indicate that the clinical and serum biochemical response to alpha-interferon in chronic hepatitis C is associated with a loss of detectable HCV genome from serum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERFERONS -- Therapeutic use
KW  - HEPATITIS C -- Treatment
KW  - RNA
KW  - AMINOTRANSFERASES
N1  - Accession Number: 6976490; Shindo, Michiko Di Bisceglie, Adrian M. Ling Cheung Wai-Kuo Shih, J. Cristiano, Karen Feinstone, Stephen M. Hoofnagle, Jay H. Shindo, M 1 Di Bisceglie, A M Cheung, L Shih, J W Cristiano, K Feinstone, S M Hoofnagle, J H; Affiliation:  1: National Institutes of Health, Bethesda, Maryland; Source Info: 11/1/91, Vol. 115 Issue 9, p700; Subject Term: INTERFERONS -- Therapeutic use; Subject Term: HEPATITIS C -- Treatment; Subject Term: RNA; Subject Term: AMINOTRANSFERASES; Number of Pages: 5p; Illustrations: 3 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
T1  - ON INTELLIGENCE...MORE OR LESS: A BIOECOLOGICAL TREATISE ON INTELLECTUAL DEVELOPMENT (Book).
JO  - Applied Cognitive Psychology
JF  - Applied Cognitive Psychology
Y1  - 1991/11//Nov/Dec91
VL  - 5
IS  - 6
M3  - Book Review
SP  - 532
EP  - 534
PB  - John Wiley & Sons, Inc.
SN  - 08884080
AB  - Reviews the book "On Intelligence...More or Less: A Bioecological Treatise on Intellectual Development, " by Stephen J. Ceci.
KW  - PSYCHOLOGY
KW  - NONFICTION
KW  - CECI, Stephen J.
KW  - ON Intelligence (Book)
N1  - Accession Number: 12003458; Schooler, Carmi 1; Affiliation:  1: Laboratory of Socio-environmental Studies, National Institute of Mental Health.; Source Info: Nov/Dec91, Vol. 5 Issue 6, p532; Subject Term: PSYCHOLOGY; Subject Term: NONFICTION; Reviews & Products: ON Intelligence (Book); People: CECI, Stephen J.; Number of Pages: 3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sandrock, Dirk
AU  - Lastoria, Secondo
AU  - Merino, Maria
AU  - Neumann, Ronald
T1  - Positive gallium-67 citrate scintigraphy in Wiskott-Aldrich syndrome with malignant lymphoma.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1991/11//
VL  - 18
IS  - 11
M3  - Article
SP  - 928
EP  - 930
SN  - 03406997
N1  - Accession Number: 71144408; Sandrock, Dirk 1 Lastoria, Secondo 1 Merino, Maria 2 Neumann, Ronald 1; Affiliation:  1: Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, USA  2: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda USA; Source Info: Nov1991, Vol. 18 Issue 11, p928; Number of Pages: 3p; Document Type: Article
L3  - 10.1007/BF02258459
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 108181300
T1  - Calcium and the aging brain: upsetting a delicate balance?
AU  - Khachaturian, Z S
Y1  - 1991/11//
N1  - Accession Number: 108181300. Language: English. Entry Date: 20120504. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985102R. 
KW  - Aging
KW  - Brain -- Metabolism
KW  - Calcium -- Metabolism
KW  - Homeostasis
KW  - Aged
KW  - Aging -- Physiology
KW  - Brain -- Physiology
KW  - Calcium -- Physiology
KW  - Calcium Binding Proteins -- Metabolism
KW  - Calcium Binding Proteins -- Physiology
KW  - Cytoplasm -- Metabolism
KW  - Cytoplasm -- Physiology
SP  - 78
EP  - 83
JO  - Geriatrics
JF  - Geriatrics
JA  - GERIATRICS
VL  - 46
IS  - 11
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
SN  - 0016-867X
AD  - Neuroscience and Neuropsychology of Aging program, National Institute on Aging, National Institutes of Health, Bethesda, MD.
U2  - PMID: 1657728.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Khachaturian, Zaven S.
T1  - Calcium and the aging brain: Upsetting a delicate balance?
JO  - Geriatrics
JF  - Geriatrics
Y1  - 1991/11//
VL  - 46
IS  - 11
M3  - Article
SP  - 79
EP  - 83
SN  - 0016867X
N1  - Accession Number: 15810289; Khachaturian, Zaven S. 1; Source Information: Nov1991, Vol. 46 Issue 11, p79; Number of Pages: 3p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 1176
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Spitzer, Robert L.
AU  - Devlin, Michael J.
AU  - Walsh, B. Timothy
AU  - Hasin, Deborah
AU  - Wing, Rena
AU  - Marcus, Marsha D.
AU  - Stunkard, Albert
AU  - Wadden, Thomas
AU  - Yanovski, Susan
AU  - Agras, Stewart
AU  - Mitchell, James
AU  - Nonas, Cathy
T1  - Binge Eating Disorder: To Be or Not to Be in DSM-IV.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1991/11//
VL  - 10
IS  - 6
M3  - Article
SP  - 627
EP  - 629
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - The diagnosis of a new eating disorder, characterized by recurrent binge eating without the characteristic compensatory features of bulimia nervosa is being studied by the members of the Eating Disorders Work Group of the DSM-IV Task Force. The central construct of the new disorder is recurrent episodes of binge eating. Therefore, it is known as Binge Eating Disorder. This diagnosis would be appropriate for a subset of overweight individuals, and may also be appropriate for some people with clinically significant binge eating problems who are able to maintain their weight in the normal range without the compensatory behaviors of bulimia nervosa.
KW  - EATING disorders -- Diagnosis
KW  - COMPULSIVE eating
KW  - BULIMIA
KW  - OVERWEIGHT persons
KW  - WEIGHT loss
KW  - OBESITY
N1  - Accession Number: 11975219; Spitzer, Robert L. 1 Devlin, Michael J. 2 Walsh, B. Timothy 2 Hasin, Deborah 2 Wing, Rena 2 Marcus, Marsha D. 2 Stunkard, Albert 3 Wadden, Thomas 3 Yanovski, Susan 4 Agras, Stewart 5 Mitchell, James 6 Nonas, Cathy 7; Affiliation:  1: Department of Psychiatry, Columbia University.  2: University of Pittsburgh School of Medicine.  3: University of Pennsylvania.  4: Clinical Neuroendocrinology Branch, National Institute of Mental Health.  5: Stanford University, School of Medicine.  6: Department of Psychiatry, University of Minnesota.  7: Program Development, United Weight Control Corporation, NYC.; Source Info: Nov1991, Vol. 10 Issue 6, p627; Subject Term: EATING disorders -- Diagnosis; Subject Term: COMPULSIVE eating; Subject Term: BULIMIA; Subject Term: OVERWEIGHT persons; Subject Term: WEIGHT loss; Subject Term: OBESITY; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wun, Lap-Ming
AU  - Pearn, Wen Lea
AD  - National Cancer Institute
AD  - Bell Labs
T1  - Assessing the Statistical Characteristics of the Mean Absolute Error or Forecasting
JO  - International Journal of Forecasting
JF  - International Journal of Forecasting
Y1  - 1991/11//
VL  - 7
IS  - 3
SP  - 335
EP  - 337
SN  - 01692070
N1  - Accession Number: 0263564; Keywords: Forecasting; Publication Type: Journal Article; Update Code: 199206
N2  - This paper assesses some general statistical characteristics of the mean absolute error of forecasting (MAEF). It shows that the MAEF is the sample estimate of the expected value of the absolute error of forecasting, and derives its mean and variance. The Central Limit Theorem is applied to establish the limiting distribution of the standardized MAEF. These results should be useful when the MAEF is used as a statistical performance criterion.
KW  - Forecasting Models; Simulation Methods          C53
L3  - http://www.sciencedirect.com/science/journal/01692070
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UR  - http://www.sciencedirect.com/science/journal/01692070
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Lap-Ming Wun
AU  - Pearn, Wen Lea
T1  - Assessing the statistical characteristics of the mean absolute error or forecasting.
JO  - International Journal of Forecasting
JF  - International Journal of Forecasting
Y1  - 1991/11//
VL  - 7
IS  - 3
M3  - Article
SP  - 335
EP  - 337
SN  - 01692070
AB  - This paper assesses some general statistical characteristics of the mean absolute error of forecasting (MAEF). It shows that the MAEF is the sample estimate of the expected value of the absolute error of forecasting, and derives its mean and variance. The Central Limit Theorem is applied to establish the limiting distribution of the standardized MAEF. These results should be useful when the MAEF is used as a statistical performance criterion. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Forecasting is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FORECASTING
KW  - STATISTICS
KW  - MATHEMATICAL analysis
KW  - ESTIMATION theory
KW  - ERRORS
KW  - CENTRAL limit theorem
N1  - Accession Number: 12132052; Lap-Ming Wun 1; Pearn, Wen Lea 2; Affiliations: 1: National Cancer Institute, Division of Cancer Prevention and Control; 2: Bell Laboratories, Holmdel, USA; Issue Info: Nov91, Vol. 7 Issue 3, p335; Thesaurus Term: FORECASTING; Thesaurus Term: STATISTICS; Thesaurus Term: MATHEMATICAL analysis; Thesaurus Term: ESTIMATION theory; Subject Term: ERRORS; Subject Term: CENTRAL limit theorem; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 104744165
T1  - A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups.
AU  - Love, L A
AU  - Leff, R L
AU  - Fraser, D D
AU  - Targoff, I N
AU  - Dalakas, M
AU  - Plotz, P H
AU  - Miller, F W
Y1  - 1991/11//1991 Nov
N1  - Accession Number: 104744165. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Autoantibodies -- Analysis
KW  - Myositis -- Classification
KW  - Adult
KW  - Dermatomyositis -- Classification
KW  - Dermatomyositis -- Immunology
KW  - Female
KW  - HLA Antigens -- Analysis
KW  - Immunogenetics
KW  - Cells
KW  - Male
KW  - Middle Age
KW  - Myositis -- Immunology
KW  - Myositis -- Pathology
KW  - Prognosis
SP  - 360
EP  - 374
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 70
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The IIM are a heterogeneous group of systemic rheumatic diseases which share the common features of chronic muscle weakness and mononuclear cell infiltrates in muscle. A number of classification schemes have been proposed for them, but none takes into consideration the marked immunologic, clinical, and genetic heterogeneity of the various clinical groups. We compared the usefulness of myositis-specific autoantibodies (anti-aminoacyl-tRNA synthetases, anti-SRP, anti-Mi-2 and anti-MAS) to the standard clinical categories (polymyositis, dermatomyositis, overlap myositis, cancer-associated myositis, and inclusion body myositis) in predicting clinical signs and symptoms, HLA types, and prognosis in 212 adult IIM patients. Although patients with inclusion body myositis (n = 26) differed in having significantly more asymmetric and distal weakness, falling, and atrophy than other patients, there were few other significant differences among the other clinical groups. In contrast, autoantibody status defined distinct sets of patients and each patient had only 1 myositis-specific autoantibody. Patients with anti-amino-acyl-tRNA synthetase autoantibodies (n = 47), compared to those without these antibodies, had significantly more frequent arthritis, fever, interstitial lung disease, and 'mechanic's hands'; HLA-DRw52; higher mean prednisone dose at survey, higher proportion of patients receiving cytotoxic drugs, and higher death rates. Those with anti-signal recognition particle antibodies (n = 7) had increased palpitations; myalgias; DR5, DRw52; severe, refractory disease; and higher death rates. Patients with anti-Mi-2 antibodies (n = 10) had increased 'V-sign' and 'shawl-sign' rashes, and cuticular overgrowth; DR7 and DRw53; and a good response to therapy. The 2 patients with anti-MAS antibodies were the only ones with alcoholic rhabdomyolysis preceding myositis; both had insulin-dependent diabetes mellitus, and both had HLA-B60, -C3, -DR4, and -DRw53. These findings suggest that myositis-specific autoantibody status is a more useful guide than clinical group in assessing patients with myositis, and that specific associations of immunogenetics, immune responses, and clinical manifestations occur in IIM. Thus the myositis-specific autoantibodies aid in interpreting the diverse symptoms and signs of myositis patients and in predicting their clinical course and prognosis. We propose, therefore, that an adjunct classification of the IIM, based on the myositis-specific autoantibody status, be incorporated into future studies of their epidemiology, etiology, and therapy.
SN  - 0025-7974
AD  - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.
U2  - PMID: 1659647.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Moss, J.
AU  - Vaughan, M.
T1  - Activation of cholera toxin and Escherichia coli heat-labile enterotoxins by ADP-ribosylation factors, a family of 20 kDa guanine nucleotide-binding proteins.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/11//
VL  - 5
IS  - 11
M3  - Article
SP  - 2621
EP  - 2627
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Cholera toxin and <em>Escherichia coli</em> heat-labile enterotoxins are responsible, in pert, for the symptomatology of cholera and traveller's diarrhoea, respectively. Effects of the toxins result from ADP-ribosylation of regulatory guanine nucleotide-binding (G) proteins; the ADP-ribosylated G protein is stabilized in on activated state, resulting in prolonged effects on its target. Toxin-catalysed ADP-ribosylation is stimulated <em>in vitro</em> by a family of guanine nucleotide-binding proteins, <em>c</em>. 20 kDa, termed ADP-ribosylation factors or ARFs. In the presence of GTP, but not GDP or adenine analogues, ARFs serve as allosteric activators of the toxin. The effects are amplified by certain phospholipids and detergents which promote guanine nucleotide binding. Six different mammalian ARF genes have been identified. They encode highly conserved, ubiquitous proteins of 175 to 181 amino acids, containing consensus domains responsible for guanine nucleotide binding. Differences in amino acid sequences are localized near the amino terminus and in the carboxy half of the protein. Although the physiological functions of ARFs have not been precisely defined, their immunological localization to the Golgi is consistent with a role in the regulated orderly movement of newly synthesized proteins from the endoplasmic reticulum, through the Golgi system to their ultimate destination. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Escherichia
KW  - ADP-ribosylation
KW  - Intestinal diseases
KW  - Proteins
KW  - Guanosine triphosphate
N1  - Accession Number: 16070062; Moss, J. 1; Vaughan, M. 1; Affiliations: 1: Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Nov1991, Vol. 5 Issue 11, p2621; Thesaurus Term: Escherichia coli; Thesaurus Term: Escherichia; Subject Term: ADP-ribosylation; Subject Term: Intestinal diseases; Subject Term: Proteins; Subject Term: Guanosine triphosphate; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Healy, Bernadine
T1  - Thallium 201 Abnormalities Found Indicative of Ischemia in Hypertrophic Cardiomyopathy.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/11/06/
VL  - 266
IS  - 17
M3  - Article
SP  - 2341
EP  - 2341
SN  - 00987484
AB  - Discusses the reversibility at rest of exercise-induced abnormalities during thallium 201 scintigraphy.  Markers of myocardial ischemia in patients with hypertrophic cardiomyopathy; Mechanism and significance of reversible-induced thallium 201 abnormalities; Measurement of myocardial lactate metabolism and hemodynamics during exercise stress test.
KW  - RADIOISOTOPE scanning
KW  - EXERCISE tests
KW  - CORONARY heart disease
KW  - HYPERTROPHIC cardiomyopathy
N1  - Accession Number: 11019969; Healy, Bernadine 1; Affiliation:  1: National Institutes of Health; Source Info: 11/6/91, Vol. 266 Issue 17, p2341; Subject Term: RADIOISOTOPE scanning; Subject Term: EXERCISE tests; Subject Term: CORONARY heart disease; Subject Term: HYPERTROPHIC cardiomyopathy; Number of Pages: 1/3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stocker, Vicki L.
T1  - AIDS and Vision Loss.
JO  - AIDS Education & Prevention
JF  - AIDS Education & Prevention
Y1  - 1991///Winter1991
VL  - 3
IS  - 4
M3  - Book Review
SP  - 376
EP  - 376
SN  - 08999546
AB  - The article reviews the book "AIDS and Vision Loss," by Edwin Kiester.
KW  - AIDS (Disease)
KW  - Nonfiction
KW  - Kiester, Edwin
KW  - AIDS & Vision Loss (Book)
N1  - Accession Number: 19582421; Stocker, Vicki L. 1; Affiliations: 1: National Institutes of Health Bethesda, Maryland.; Issue Info: Winter1991, Vol. 3 Issue 4, p376; Thesaurus Term: AIDS (Disease); Subject Term: Nonfiction; Reviews & Products: AIDS & Vision Loss (Book); People: Kiester, Edwin; Number of Pages: 2/3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lawrence, Jeffrey B.
AU  - Friedman, Beth S.
AU  - Travis, William D.
AU  - Chinchilli, Vernon M.
AU  - Metcalfe, Dean D.
AU  - Gralnick, Harvey R.
T1  - Hematologic Manifestations of Systemic Mast Cell Disease: A Prospective Study of Laboratory and Morphologic Features and Their Relation to Prognosis.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/12//
VL  - 91
IS  - 5
M3  - Article
SP  - 612
EP  - 624
SN  - 00029343
AB  - Examines the hematologic presentation of systemic mast cell disease (SMCD).  Evolution of bone marrow mast cell infiltration and its relationship to hematologic neoplasia; Bone marrow biopsy diagnostic for SMCD; Alkaline phosphatase level; Hemoglobin and absolute lymphocyte count; Predictors of patient survival.
KW  - MAST cell disease
KW  - BONE marrow cells
KW  - MAST cells
KW  - HEMATOLOGY
N1  - Accession Number: 10949352; Lawrence, Jeffrey B. 1,2 Friedman, Beth S. 3 Travis, William D. 4 Chinchilli, Vernon M. 5 Metcalfe, Dean D. 3 Gralnick, Harvey R. 1; Affiliation:  1: Hematology Service, Clinical Pathology Department, Clinical Center  2: National Institutes of Health, Bethesda, Maryland  3: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases  4: Laboratory of Pathology, National Cancer Institute  5: Medical College of Virginia, Virginia Commonwealth University; Source Info: Nov91, Vol. 91 Issue 5, p612; Subject Term: MAST cell disease; Subject Term: BONE marrow cells; Subject Term: MAST cells; Subject Term: HEMATOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Illustrations: 5 Black and White Photographs, 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Freidman, Theodore C.
AU  - Thomas, Pamela M.
AU  - Fleisher, Thomas A.
AU  - Feuillan, Penelope
AU  - Parker, Robert I.
AU  - Cassorla, Fernando
AU  - Chrousos, George P.
T1  - Frequent Occurrence of Asplenium and Cholelithiasis in Patients With Autoimmune Polyglandular Disease Type I.
JO  - American Journal of Medicine
JF  - American Journal of Medicine
Y1  - 1991/12//
VL  - 91
IS  - 5
M3  - Article
SP  - 625
EP  - 630
SN  - 00029343
AB  - Examines the occurrence of asplenism and gallstones in patients with autoimmune polyglandular disease type I.  Endocrine testing; Analysis of peripheral blood sugar smear; Lymphocyte immunophenotyping; Use of abdominal ultrasound to detect asplenism and gallstones; Liver-spleen scan.
KW  - AUTOIMMUNE diseases
KW  - SPLEEN -- Diseases
KW  - GALLSTONES
N1  - Accession Number: 10949353; Freidman, Theodore C. 1,2 Thomas, Pamela M. 1,3 Fleisher, Thomas A. 4 Feuillan, Penelope 1 Parker, Robert I. 5 Cassorla, Fernando 1 Chrousos, George P. 1; Affiliation:  1: Developmental Endocrinology Branch, National Institutes of Health  2: Laboratory of Developmental Neurology, National Institutes of Health  3: Cell Biology and Metabolism Branch, National Institutes of Health  4: National Institute of Child Health and Human Development and Immunology Service, National Institutes of Health  5: Hematology Service, National Institutes of Health; Source Info: Nov91, Vol. 91 Issue 5, p625; Subject Term: AUTOIMMUNE diseases; Subject Term: SPLEEN -- Diseases; Subject Term: GALLSTONES; Number of Pages: 6p; Illustrations: 5 Black and White Photographs, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Drake, John W.
T1  - TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS.
JO  - Annual Review of Genetics
JF  - Annual Review of Genetics
Y1  - 1991/12//
VL  - 25
M3  - Article
SP  - 89
EP  - 123
PB  - Annual Reviews Inc.
SN  - 00664197
AB  - Focuses on the positive control of transcription and the findings that steroid hormone receptors act as ligand-inducible transcription factors that bind to cognate enhancer elements present in target genes.  Hormone response elements and DNA-binding domains of steroid hormone receptors; Binding of estrogen and progesterone receptors as dimers to palindromic response elements; Factors required for DNA binding; Autonomous transcription activation functions.
KW  - GENETIC transcription
KW  - STEROID hormones
KW  - LIGANDS
KW  - DNA
KW  - ESTROGEN
KW  - PROGESTERONE
N1  - Accession Number: 12353711; Drake, John W. 1; Affiliation:  1: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, North Carolina; Source Info: 1991, Vol. 25, p89; Subject Term: GENETIC transcription; Subject Term: STEROID hormones; Subject Term: LIGANDS; Subject Term: DNA; Subject Term: ESTROGEN; Subject Term: PROGESTERONE; Number of Pages: 35p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Chapman, M. M.;
AU  - Goldspiel, B. R.;
AU  - DeChristoforo, R.;
AU  - Gallelli, J. F.;
T1  - Reporting and classifying chemotherapy prescribing errors
CT  - Reporting and classifying chemotherapy prescribing errors
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1991/12/01/
VL  - 26
IS  - Dec
SP  - P
EP  - E
AD  - Pharmacy Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bldg. 10, Rm. 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 29-00798; Language: English; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Information Processing and Literature
N2  - A standardized reporting form for prescribing errors found while checking chemotherapy and investigational drug orders was developed and a patient outcome classification system for these errors was formulated. A prescribing error was defined as any order that could not be dispensed exactly as the physician had written. Based on historical information, common prescribing errors were identified and a sample reporting form was developed and subsequently modified. This final version was then distributed to all pharmacists involved in checking protocol orders and used to record all errors for 6 weeks. Personal computer database programs were used to analyze the data. A patient outcome classification system was developed based on modified FDA drug recall criteria. Assuming the order had been administered to the patient, the authors used their judgment to classify each error as having either serious, temporary or medically reversible adverse effects, or no effect on the patient. Of 2020 orders checked, 397 (19.7%) contained prescribing errors. Using our outcome criteria, 47 (2.3%) of the 2020 orders checked were considered serious errors, 112 (5.5%) temporary or medically reversible errors, and 238 (11.8%) errors would have no effect on the patient. In conclusion, a useful data collection form was developed and will be used as part of the departmental quality assurance program. A patient outcome classification system was developed; however, each error must be evaluated individually.
KW  - ASHP meeting abstracts--medication error reporting forms;
KW  - Forms--errors, medication--reporting, hospital pharmacy;
KW  - Errors, medication--reports--forms, hospital pharmacy;
KW  - Pharmacy, institutional, hospital--administration--medication error reporting forms;
KW  - Documentation--errors, medication--reporting, hospital pharmacy;
KW  - Prescribing--errors, medication--reporting, hospital pharmacy;
KW  - Practice Interest Areas--Oncology--meeting presentations;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Germana, S.
AU  - Shinohara, N.
T1  - Qa-1/Tla region alloantigen-specific CTL with αβ receptor.
JO  - Immunology
JF  - Immunology
Y1  - 1991/12//
VL  - 74
IS  - 4
M3  - Article
SP  - 578
EP  - 582
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Recent studies involving T cells that express γδ T-cell receptor (γδTcR) have raised the possibility that Qa-1/Tla region class I major histocompatibility complex (MHC)-like molecules are antigen-presenting molecules for γδTcR. In this report, cytotoxic T lymphocyte (CTL) clones specific for a Qa-1/Tla region gene product were isolated from a bulk B10.QBR (Kb, Ib, Dq Qa-l/Tlab) anti-B10.MBR (Kb, Ik, Dq, Qa/Tlaa) CTL line. These CTL lysed blasts from all Qa-1a strains regardless of the H-2 haplotype, indicating that the recognition of the Qa-1 antigen by these CTL is not restricted by other class I molecules. In bulk populations, CTL activity of this specificity was found only in the CD8+CD4- subpopulation. Accordingly, all established CTL clones were phenotyped as Thy-1+, CD8+CD4-. Furthermore, these clones were shown to express αβTcR rather than γδTcR. Thus, the results indicate that Qa-1 antigen can be recognized by αβTcR T cells in a manner similar to recognition of classical class I molecules. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - CELL receptors
KW  - MAJOR histocompatibility complex
KW  - MOLECULES
KW  - GENES
KW  - CLONING
N1  - Accession Number: 13487790; Germana, S. 1 Shinohara, N. 1; Affiliation:  1: Immunology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec91, Vol. 74 Issue 4, p578; Subject Term: T cells; Subject Term: CELL receptors; Subject Term: MAJOR histocompatibility complex; Subject Term: MOLECULES; Subject Term: GENES; Subject Term: CLONING; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brooks, G. F.
AU  - Olinger, L.
AU  - Lammel, C. J.
AU  - Bhat, K. S.
AU  - Calvello, C. A.
AU  - Palmer, M. L.
AU  - Knapp, J. S.
AU  - Stephens, R. S.
T1  - Prevalence of gene sequences coding for hypervariable regions of Opa (protein II) in Neisseria gonorrhoeae.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1991/12//
VL  - 5
IS  - 12
M3  - Article
SP  - 3063
EP  - 3072
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Opas (protein IIs) are a family of surface-exposed proteins of <em>Neisseria gonorrhoeae</em>. Each strain of <em>N. gonorrhoeae</em> has multiple (10-11) genes encoding for Opas. Identifiable elements in <em>opa</em> genes include the coding repeat within the signal sequence, conserved 5′ and 3′ regions, and hypervariable regions (HV1 and HV2) located within the structural gene. <em>N. gonorrhoeae</em> strains appear to have many biological properties in common that are either HV-region-mediated or associated with the presence of specific HV regions, suggesting that HV regions could be found in many clinical isolates. Oligonucleotides from three source strains representing three conserved regions of <em>opa</em>, 12 HV1 regions, and 14 HV2 regions were used by dot blot analysis to probe 120 clinicial isolates of <em>N. gonorrhoeae</em>. The probe for the coding repeat hybridized to all 120 strains, the 3′ conserved-region probe reacted with 98% of the strains, and the 5′ conserved-region probe with 90% of the strains. Nine HV1 probes hybridized to 3.3-39.2% of the strains, and 13 of the HV2 probes hybridized to 1.7-25% of the isolates. Analysis of the number of probes that hybridized to each of the isolates showed that 19% did not hybridize with any of the HV1 probes and 25% did not hybridize with any of the HV2 probes. Approximately three-quarters of the isolates hybridized with one, two or three of the HV1 probes or one, two or three of the HV2 probes; 89% of the isolates hybridized to least one HV1 or one HV2 probe. The data indicate that some genes encoding HV regions of <em>N. gonorrhoeae</em> Opa proteins are widely distributed in nature. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Hybridization
KW  - Proteins
KW  - Neisseria gonorrhoeae
KW  - Genes
KW  - Oligonucleotides
N1  - Accession Number: 16253422; Brooks, G. F. 1; Olinger, L. 1; Lammel, C. J. 1; Bhat, K. S. 2; Calvello, C. A. 1; Palmer, M. L. 1; Knapp, J. S. 3; Stephens, R. S. 1; Affiliations: 1: Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA; 2: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; 3: Division of Sexually Transmitted Disease Laboratory Research, Centers for Disease Control, Atlanta, Georgia 30333, USA; Issue Info: Dec1991, Vol. 5 Issue 12, p3063; Thesaurus Term: Hybridization; Subject Term: Proteins; Subject Term: Neisseria gonorrhoeae; Subject Term: Genes; Subject Term: Oligonucleotides; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 10p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104747418
T1  - Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine.
AU  - De Conno, F
AU  - Caraceni, A
AU  - Martini, C
AU  - Spoldi, E
AU  - Salvetti, M
AU  - Ventafridda, V
Y1  - 1991/12//1991 Dec
N1  - Accession Number: 104747418. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Hyperalgesia -- Chemically Induced
KW  - Morphine -- Adverse Effects
KW  - Myoclonus -- Chemically Induced
KW  - Drug Administration Schedule
KW  - Injections, Intraspinal
KW  - Male
KW  - Middle Age
KW  - Morphine -- Administration and Dosage
SP  - 337
EP  - 339
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 47
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy.
U2  - PMID: 1784504.
DO  - 10.1016/0304-3959(91)90225-M
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-05455-010
AN  - 2006-05455-010
AU  - Lamb, Michael E.
T1  - 'N' is for knowledge and the Nebraska symposium.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1991/12//
VL  - 36
IS  - 12
SP  - 1044
EP  - 1046
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-05455-010. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Early Childhood Development; Emotional Development; Infant Development; Psychosocial Development. Minor Descriptor: Facial Expressions; Motivation. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Thompson, Ross A. (Ed). Nebraska Symposium on Motivation, Vol. 36: Socioemotional Development, 1988=Lincoln: University of Nebraska Press, 1990. 492 pp.  $33.95 hardcover; $18.95 paperback; 1990. References Available: Y. Page Count: 3. Issue Publication Date: Dec, 1991. 
AB  - Reviews the book, Nebraska Symposium on Motivation, Vol. 36: Socioemotional Development, 1988 edited by Ross A. Thompson (1990). This book represents an important addition to the literature on social and emotional development, particularly in infancy and early childhood. However, in this volume compared with many early collections on emotional development, relatively little attention is paid in this volume to techniques for describing the morphology of facial expressions of emotion. With few and modest exceptions, however, this volume will be an indispensable source for those who study social or emotional development, representing, as it does, the only volume in which most major programs of research and lines of theorizing concerning emotional development are brought together. The volume will also be of great value to those who study other aspects of development and wish to learn of recent developments in the study of emotional development. It deserves wide readership and attention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - infancy
KW  - socioemotional development
KW  - early childhood
KW  - facial expressions
KW  - emotions
KW  - motivation
KW  - 1991
KW  - Early Childhood Development
KW  - Emotional Development
KW  - Infant Development
KW  - Psychosocial Development
KW  - Facial Expressions
KW  - Motivation
KW  - 1991
U2  - Thompson, Ross A. (Ed). (1990); Nebraska Symposium on Motivation, Vol. 36: Socioemotional Development, 1988; Lincoln: University of Nebraska Press, 1990. 492 pp.  $33.95 hardcover; $18.95 paperback; 0-8032-4421-5 (Hardcover); 0-8032-9415-8 (Paperback).
DO  - 10.1037/031241
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - de Smet, Marc D.
AU  - Nussenbatt, Robert B.
T1  - Ocular Manifestations of AIDS.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1991/12/04/
VL  - 266
IS  - 21
M3  - Article
SP  - 3019
EP  - 3022
SN  - 00987484
AB  - Discusses the several case reports related to the diagnosis of AIDS through ocular manifestations.  Ocular toxoplasmosis in a child infected with HIV; Demonstration of the active phase of acute retina necrosis; Progression of a cotton-wool spot in the eye.
KW  - OCULAR manifestations of general diseases
KW  - AIDS (Disease)
KW  - HIV (Viruses)
KW  - OCULAR toxoplasmosis
N1  - Accession Number: 10980313; de Smet, Marc D. 1 Nussenbatt, Robert B. 1; Affiliation:  1: Laboratory of Immunology, National Eye Institute; Source Info: 12/4/91, Vol. 266 Issue 21, p3019; Subject Term: OCULAR manifestations of general diseases; Subject Term: AIDS (Disease); Subject Term: HIV (Viruses); Subject Term: OCULAR toxoplasmosis; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ravussin, Eric
AU  - Bogardus, Clifton
T1  - A brief overview of human energy metabolism and its relationship to essential obesity.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/01//
VL  - 55
IS  - 1
M3  - Article
SP  - 242S
EP  - 245S
SN  - 00029165
AB  - Twenty-four hour energy expenditure (24EE) can be measured in a respiratory chamber. 24EE is comprised of the basal metabolic rate, the thermic effect of food, and the energy cost of physical activity. The major determinant of 24EE, fat-free mass, accounts for ~80% of the variance observed between individuals. Genetic factors seem to be the cause of the familial aggregation of 24EE in man. The variability of 24EE for a given body size and composition is of importance because a low metabolic rate is a major risk factor for weight gain in man. There is increasing evidence that obesity, often an inherited disorder, cannot always be attributed to gluttony and sloth. Similar to the need to treat essential hypertension, there is a need to treat a disorder perhaps best called essential obesity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Energy metabolism
KW  - REGULATION
KW  - Obesity
KW  - Genetic disorders -- Treatment
KW  - Human body composition
KW  - Indirect calorimetry
KW  - Lean body mass
KW  - Pima (North American people)
KW  - body composition
KW  - Pima Indians
N1  - Accession Number: 94402885; Ravussin, Eric 1; Bogardus, Clifton 1; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ; Issue Info: Jan1992, Vol. 55 Issue 1, p242S; Thesaurus Term: RESEARCH; Subject Term: Energy metabolism; Subject Term: REGULATION; Subject Term: Obesity; Subject Term: Genetic disorders -- Treatment; Subject Term: Human body composition; Subject Term: Indirect calorimetry; Subject Term: Lean body mass; Subject Term: Pima (North American people); Author-Supplied Keyword: body composition; Author-Supplied Keyword: Pima Indians; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Shopland, Donald R.
AU  - Niemcryk, Steve J.
AU  - Marconi, Katherine M.
T1  - Geographic and Gender Variations in Total Tobacco Use.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/01//
VL  - 82
IS  - 1
M3  - Article
SP  - 103
EP  - 106
PB  - American Public Health Association
SN  - 00900036
AB  - This study is the first to provide complete information on prevalence rates by gender and geographic variation for each type of tobacco product used in the United States. Results indicate that, in nearly half of all states, total tobacco use in men exceeded 40% and , in four states, exceeded 50%, In women, only Nevada, Kentucky, and Michigan reported prevalence exceeding, 33%. Results also indicate, however, that concurrent use of multiple tobacco forms is relatively rare. Substantial regional variation in male total tobacco use was evident, with southern males exhibiting the highest prevalence rate (44.6%). As a result, this region represents a target group in special need of comprehensive and effective tobacco use interventions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOBACCO use
KW  - DEMOGRAPHY
KW  - SMOKING
KW  - TOBACCO industry
KW  - UNITED States
N1  - Accession Number: 9405130023; Shopland, Donald R. 1 Niemcryk, Steve J. 2 Marconi, Katherine M. 1; Affiliation:  1: Cancer Control Sciences Program, National Cancer Institute, Bethesda, Maryland  2: R. O. W. Sciences, Inc., Rockville, Maryland; Source Info: Jan1992, Vol. 82 Issue 1, p103; Subject Term: TOBACCO use; Subject Term: DEMOGRAPHY; Subject Term: SMOKING; Subject Term: TOBACCO industry; Subject Term: UNITED States; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 453991 Tobacco Stores; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bachrach, Christine A.
AU  - Stolley, Kathy Shepherd
AU  - London, Kathryn A.
T1  - Relinquishment of Premarital Births: Evidence from National Survey Data.
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
Y1  - 1992/01//Jan/Feb92
VL  - 24
IS  - 1
M3  - Article
SP  - 27
EP  - 48
PB  - Guttmacher Institute, Inc.
SN  - 00147354
AB  - According to 1982 and 1988 NSFG data, unmarried white women are far less likely than they were in the early 1970s to place their children for adoption. The levels of relinquishment among black women have remained low throughout this period, and relinquishment among Hispanic women may be virtually nonexistent. Multivariate analysis of the determinants of relinquishment among unmarried non-Hispanic white women suggests that having a well-educated mother, being in school at the time of conception, having no labor force experience, and being older are positively associated with placing a child for adoption. Sons were found to be less likely to be relinquished than daughters. (Family Planning Perspectives, 24:27, 1992) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Family Planning Perspectives is the property of Guttmacher Institute, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADOPTION
KW  - SINGLE women
KW  - WHITE women
KW  - MULTIVARIATE analysis
KW  - DECISION making
KW  - DATE of conception
KW  - BLACK women
KW  - MEDICAL care
KW  - MEDICAL sciences
N1  - Accession Number: 24229497; Bachrach, Christine A. 1 Stolley, Kathy Shepherd 2 London, Kathryn A. 3; Affiliation:  1: Statistician, Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Md.  2: Instructor, Department of Sociology and Criminal Justice, Old Dominion University, Norfolk, Va.  3: Statistician, National Center for Health Statistics, Hyattsville, Md.; Source Info: Jan/Feb92, Vol. 24 Issue 1, p27; Subject Term: ADOPTION; Subject Term: SINGLE women; Subject Term: WHITE women; Subject Term: MULTIVARIATE analysis; Subject Term: DECISION making; Subject Term: DATE of conception; Subject Term: BLACK women; Subject Term: MEDICAL care; Subject Term: MEDICAL sciences; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 7138
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wiseman, Claire V.
AU  - Gray, James J.
AU  - Mosimann, James E.
AU  - Ahrens, Anthony H.
T1  - Cultural Expectations of Thinness in Women: An Update.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1992/01//
VL  - 11
IS  - 1
M3  - Article
SP  - 85
EP  - 89
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - An investigation of current American society's depiction of the ideal female body was performed. Body measurements of Playboy magazine centerfolds and Miss America contestants for 1979 - 1988 indicated body weight 13-19% below expected weight for women in that age group. Miss America contestants showed a significant decrease in expected weight between 1979 and 1988. Comparisons were made with an earlier study which had demonstrated that body measurements of both groups had decreased during the period 1959 - 1978. Diet-for-weight-loss and exercise articles in six women's magazines were tabulated for 1959 - 1988. A significant increase in both diet articles and exercise articles occurred during this period. These findings suggest that the overvaluation of thinness continues and thinness is now sought through both dieting and exercise. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEANNESS
KW  - BODY weight
KW  - DIET
KW  - BEAUTY pageant contestants
KW  - FEMALES
KW  - THIN people
KW  - EXERCISE
KW  - UNITED States
N1  - Accession Number: 11987771; Wiseman, Claire V. 1 Gray, James J. 2 Mosimann, James E. 3 Ahrens, Anthony H. 1; Affiliation:  1: Clinical psychology program, American University.  2: American University.  3: Computer Division, National Institutes of Health and American University.; Source Info: Jan1992, Vol. 11 Issue 1, p85; Subject Term: LEANNESS; Subject Term: BODY weight; Subject Term: DIET; Subject Term: BEAUTY pageant contestants; Subject Term: FEMALES; Subject Term: THIN people; Subject Term: EXERCISE; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanton, Bonita F.
AU  - Clemens, John D.
AU  - Black, Robert E.
T1  - Addressing national and regional health needs: A framework for health planning.
JO  - International Journal of Health Planning & Management
JF  - International Journal of Health Planning & Management
Y1  - 1992/01//
VL  - 7
IS  - 1
M3  - Article
SP  - 23
EP  - 36
SN  - 07496753
N1  - Accession Number: 64206369; Stanton, Bonita F. 1; Clemens, John D. 2; Black, Robert E. 3; Affiliations: 1: Department of Pediatrics, University of Maryland Medical School, University of Maryland, 700 West Lombard Street, Baltimore, Maryland 21201, USA; 2: Epidemiology Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA; 3: Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA; Issue Info: Jan1992, Vol. 7 Issue 1, p23; Number of Pages: 14p; Document Type: Article
L3  - 10.1002/hpm.4740070104
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Fisher, Gary J.
AU  - Tavakkol, Amir
AU  - Griffiths, Christopher E. M.
AU  - Elder, James T.
AU  - Qing-Yu Zhang
AU  - Finkel, Lawrence
AU  - Danielpour, David
AU  - Glick, Adam B.
AU  - Higley, Howard
AU  - Ellingsworth, Larry
AU  - Voorhees, John J.
T1  - Differential Modulation of Transforming Growth Factor-β1 Expression and Mucin Deposition by Retinoic Acid and Sodium Lauryl Sulfate in Human Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/01//
VL  - 98
IS  - 1
M3  - Article
SP  - 102
EP  - 108
SN  - 0022202X
AB  - Immunohistochemical staining of skin sections with two polyclonal antibodies (anti-CC 1-30 and anti-LC 1-30), specific for transforming growth factor-β1, revealed increased extracellular and decreased intracellular expression of transforming growth factor-β1in retinoic acid-treated, compared to vehicle-treated, skin. Transforming growth factor-β1staining, with both antibodies, was most marked in the upper layers of the epidermis, although dermal staining was also evident. The modulation of transforming growth factor-β1expression by retinoic acid occurred in the absence of any change in its mRNA level. Transforming growth factor-β1protein, as detected by rabbit polyclonal antibody (anti-LC 50-75) and mRNA, were only minimally detected in either retinoic acid- or vehicle-treated skin. Similar changes in TGF-β1and TGF-β2 immunoreactivity and mRNA levels, as observed in retinoic acid-treated skin, were observed in skin following topical application of the irritant sodium lauryl sulfate, indicating that the alterations induced by retinoic acid were not specific. In contrast, mucin depositions which is induced by transforming growth factor-β, was elevated in retinoic acid-treated but not sodium lauryl sulfate-treated skin. Cultured adult human keratinocytes also expressed predominantly transforming growth factor-β1 protein, as measured by ELISA, and mRNA. Treatment of keratinocytes with retinoic acid resulted in a 50% induction of transforming growth factor-β1 protein, without any detectable change in transforming growth factor-β2. These data demonstrate disassociation of modulation of transforming growth factor-β1 expression and mucin deposition by retinoic acid and sodium lauryl sulfate in human skin in vivo. Whereas alterations in transforming growth factor expression were observed in both retinoic acid-and sodium lauryl sulfate-treated skin, accumulation of mucin was specific to retinoic acid-treated skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GROWTH factors
KW  - KERATINOCYTES
KW  - TRETINOIN
KW  - MUCINS
KW  - IMMUNOGLOBULINS
KW  - SODIUM compounds
N1  - Accession Number: 12495896; Fisher, Gary J. 1 Tavakkol, Amir 1 Griffiths, Christopher E. M. 1 Elder, James T. Qing-Yu Zhang 1 Finkel, Lawrence 1 Danielpour, David 2 Glick, Adam B. 3 Higley, Howard 4 Ellingsworth, Larry 4 Voorhees, John J. 1; Affiliation:  1: Department of Dermatology, University of Michigan, Ann Arbor, Michigan.  2: National Institutes of Health, Laboratory of Chemoprevention, Bethesda, Maryland.  3: National Cancer Institute, Bethesda, Maryland.  4: Celtrix Laboratories, Palo Alto, California, U.S.A.; Source Info: Jan1992, Vol. 98 Issue 1, p102; Subject Term: GROWTH factors; Subject Term: KERATINOCYTES; Subject Term: TRETINOIN; Subject Term: MUCINS; Subject Term: IMMUNOGLOBULINS; Subject Term: SODIUM compounds; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212391 Potash, Soda, and Borate Mineral Mining; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12495896
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104740346
T1  - Patterns of infection in patients with aplastic anemia and the emergence of Aspergillus as a major cause of death.
AU  - Weinberger, M
AU  - Elattar, I
AU  - Marshall, D
AU  - Steinberg, S M
AU  - Redner, R L
AU  - Young, N S
AU  - Pizzo, P A
Y1  - 1992/01//1992 Jan
N1  - Accession Number: 104740346. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Anemia, Aplastic -- Complications
KW  - Aspergillosis -- Mortality
KW  - Cross Infection -- Mortality
KW  - Age Factors
KW  - Anemia, Aplastic -- Mortality
KW  - Aspergillosis -- Epidemiology
KW  - Aspergillosis -- Etiology
KW  - Cause of Death
KW  - Chi Square Test
KW  - Cross Infection -- Epidemiology
KW  - Cross Infection -- Etiology
KW  - Fever -- Epidemiology
KW  - Fever -- Etiology
KW  - Fever of Unknown Origin -- Epidemiology
KW  - Fever of Unknown Origin -- Etiology
KW  - Human
KW  - Incidence
KW  - National Institutes of Health (U.S.)
KW  - Retrospective Design
KW  - United States
SP  - 24
EP  - 43
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 71
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Patterns of infection were studied in 150 patients with aplastic anemia who were admitted to the Clinical Hematology Branch, National Institutes of Health, between January 1978 and December 1989 for immunosuppressive therapy. Sixty percent of the patients were males, 71% were white, their mean age was 33.6 years (median, 27.5; range, 1-75), and 83% had severe aplastic anemia. One hundred three patients developed 1 or more febrile episodes during the study period. The risk factors for developing a febrile episode included a low Absolute Neutrophil Count (ANC) and Absolute Monocyte Count (AMC) at admission and the presence of an indwelling central venous catheter (Hickman-Broviack or Port-A-Cath). A total of 289 febrile events were studied, including unexplained fever (FUO) in 89 (31%), microbiologically documented infection (MBDI) in 137 (47%), and clinically documented infection (CDI) in 63 patients (22%). Compared to documented infections (MBDI) or CDI), FUO events were associated with a higher frequency of rigors, signs and symptoms of serum sickness, and treatment regimens known to cause fevers. None of the FUO events had a fatal outcome, even if the antibiotic therapy was discontinued before day 7. Among CDI events, bacteria were the most commonly defined etiologic agent (67%), followed by fungi (23%), viruses (7%), and parasites (3%). The patterns of bacterial infections in patients with aplastic anemia were similar to those observed in patients with cancer-related neutropenia. Twenty-one patients (15%) developed invasive fungal infections (aspergillus, 11; candida, 7; and both, 3), which were fatal in 19 (90%). Fungal infections accounted for 30% of the secondary infectious events and for 55% of fatal infectious events. The only identifiable risk factors for developing a fungal infection were the degree of neutropenia and monocytopenia at initial admission or final evaluation. Invasive pulmonary aspergillosis developed despite empirical amphotericin B therapy and was associated with a high incidence of fatal pulmonary hemorrhage (10 of 13 patients [77%]). Infection was responsible for 36 (62%) of the deaths observed during the study period and hemorrhage alone for 4 (7%). However, 20 of the patients who died of infection had concomitant hemorrhage. No significant drop in ANC, AMC, or platelet count could be demonstrated during a fatal infectious event as compared to a nonfatal infectious event. Invasive fungal infections, predominantly with aspergillus and candida, emerged in our study as the major causes of mortality in patients with aplastic anemia. Without bone marrow recovery the prognosis associated with invasive mycoses was grave.
SN  - 0025-7974
AD  - Infectious Disease Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
U2  - PMID: 1549057.
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DB  - rzh
ER  - 

TY  - JOUR
AU  - Riggin, Leslie J. C.
AU  - Grasso, Patrick G.
AU  - Westcott, Mary L.
T1  - A framework for evaluating housing and community development partnership projects.
JO  - Public Administration Review
JF  - Public Administration Review
Y1  - 1992/01//Jan/Feb92
VL  - 52
IS  - 1
M3  - Article
SP  - 40
PB  - Wiley-Blackwell
SN  - 00333352
AB  - This article discusses a framework for evaluating housing and community development partnership projects. Not only the federal government but also state and local governments see partnerships as a tool for addressing housing and community development needs. In response to limited federal dollars, local governments in communities throughout the United States have created public-private partnerships to achieve a variety of goals in housing and community development. As the federal budget deficit has mounted in recent years, public-private partnerships have become an increasingly popular vehicle for both limiting federal expenditures and leveraging federal funds. In particular, partnerships have been seen as a way to combat growing economic and urban problems and to maintain needed housing and community development programs. Although no one federal program has the direct objective of supporting public-private partnerships, the popularity of partnerships as a federal policy tool is evident from the large number of federal programs that provide funds or other forms of support to local partnership projects.
KW  - HOUSING
KW  - BUDGET
KW  - PARTNERSHIP (Business)
KW  - COMMUNITY development
KW  - REGIONAL planning
KW  - HOUSING policy
KW  - UNITED States
KW  - HOUSING PROGRAMS
KW  - PROGRAM PLANNING, IMPLEMENTATION, AND EVALUATION
N1  - Accession Number: 9203160005; Riggin, Leslie J. C. 1; Grasso, Patrick G. 1; Westcott, Mary L. 2; Affiliations: 1: U.S. General Accounting Office.; 2: National Institute on Drug Abuse.; Issue Info: Jan/Feb92, Vol. 52 Issue 1, p40; Thesaurus Term: HOUSING; Thesaurus Term: BUDGET; Thesaurus Term: PARTNERSHIP (Business); Thesaurus Term: COMMUNITY development; Thesaurus Term: REGIONAL planning; Subject Term: HOUSING policy; Subject: UNITED States; Author-Supplied Keyword: HOUSING PROGRAMS; Author-Supplied Keyword: PROGRAM PLANNING, IMPLEMENTATION, AND EVALUATION; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 624229 Other Community Housing Services; NAICS/Industry Codes: 925110 Administration of Housing Programs; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - CHAP
ID  - 1992-97455-016
AN  - 1992-97455-016
AU  - Weiss, Steven
AU  - Fielding, Jonathan
ED  - Keita, Gwendolyn Puryear
ED  - Sauter, Steven L.
ED  - Keita, Gwendolyn Puryear, (Ed)
ED  - Sauter, Steven L., (Ed)
T1  - Health promotion, education, and treatment: Summary of audience comments.
T2  - Work and well-being:  An agenda for the 1990s.
Y1  - 1992///
SP  - 65
EP  - 67
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-153-1
N1  - Accession Number: 1992-97455-016. Partial author list: First Author & Affiliation: Weiss, Steven; National Heart, Lung, and Blood Institute, Bethesda, MD, US. Release Date: 19921001. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Comment/Reply. ISBN: 1-55798-153-1, Paperback. Language: English. Major Descriptor: Health Promotion; Stress Management; Working Conditions. Minor Descriptor: Health; Health Education; Mental Health; Occupational Stress; Primary Mental Health Prevention; Treatment. Classification: Promotion & Maintenance of Health & Wellness (3365); Industrial & Organizational Psychology (3600). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. 
AB  - Summarizes the comments made by the audience on the paper 'Health promotion, education, and treatment' (see record [rid]1992-97455-003[/rid]). discussion and recommendations focused on the necessity for interdisciplinary, multi-modal programs that involved employer, employee and union, health promotion expertise, and relevant representation from the community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health
KW  - emotional health
KW  - psychological health
KW  - stress management skills
KW  - workplace
KW  - health promotion
KW  - health education
KW  - treatment
KW  - 1992
KW  - Health Promotion
KW  - Stress Management
KW  - Working Conditions
KW  - Health
KW  - Health Education
KW  - Mental Health
KW  - Occupational Stress
KW  - Primary Mental Health Prevention
KW  - Treatment
KW  - 1992
DO  - 10.1037/10108-016
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 1992-97455-017
AN  - 1992-97455-017
AU  - Curtis, E. Carroll
AU  - Eaton, William W.
AU  - Gillespie, Robin Mary
AU  - Manderscheid, Ronald W.
AU  - Wagener, Diane
ED  - Keita, Gwendolyn Puryear
ED  - Sauter, Steven L.
ED  - Keita, Gwendolyn Puryear, (Ed)
ED  - Sauter, Steven L., (Ed)
T1  - Surveillance of psychological disorders in the workplace: Panel comments.
T2  - Work and well-being:  An agenda for the 1990s.
Y1  - 1992///
SP  - 97
EP  - 114
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-153-1
N1  - Accession Number: 1992-97455-017. Partial author list: First Author & Affiliation: Curtis, E. Carroll; Westinghouse Corporation, Pittsburgh, PA, US. Release Date: 19921001. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Comment/Reply. ISBN: 1-55798-153-1, Paperback. Language: English. Major Descriptor: Evaluation; Mental Disorders; Risk Factors; Working Conditions. Classification: Psychological Disorders (3210); Industrial & Organizational Psychology (3600). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 18. 
AB  - Individual panel members' comments on the paper 'Surveillance of psychological disorders in the workplace' (see record [rid]1992-97455-004[/rid]). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - risk factors
KW  - psychological disorders
KW  - workplace
KW  - 1992
KW  - Evaluation
KW  - Mental Disorders
KW  - Risk Factors
KW  - Working Conditions
KW  - 1992
DO  - 10.1037/10108-017
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1992-97455-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09778-001
AN  - 2005-09778-001
AU  - Regier, Darrel A.
AU  - Keith, Samuel J.
T1  - Soviet Professional Mental Health Visit to the United States: An Update of Activities.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1992///
VL  - 18
IS  - 1
SP  - 1
EP  - 5
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Regier, Darrel A., Division of Clinical Research, National Institute of Mental Health, Parklawn Bldg., Rm. 10-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09778-001. Partial author list: First Author & Affiliation: Regier, Darrel A.; Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051011. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Psychology; Health Care Delivery; Mental Health Personnel; Mental Health Services. Minor Descriptor: Forensic Psychology; Mental Health Programs. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: USSR; US. Page Count: 5. Issue Publication Date: 1992. 
AB  - On September 22, 1990, a Soviet Delegation arrived in Washington, DC, for a 2-week professional visit designed to provide the Delegation with an overview of US mental health research, forensic practice, and service delivery systems. The agenda for the visit included both scientific presentations and site visits to a wide range of mental health and forensic programs in the Washington metropolitan area, as well as smaller group visits to programs in California, Pittsburgh, Chicago, and Wisconsin. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Soviet delegation
KW  - mental health visits
KW  - US mental health research
KW  - service delivery
KW  - forensic practice
KW  - 1992
KW  - Cross Cultural Psychology
KW  - Health Care Delivery
KW  - Mental Health Personnel
KW  - Mental Health Services
KW  - Forensic Psychology
KW  - Mental Health Programs
KW  - 1992
DO  - 10.1093/schbul/18.1.1
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09778-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-10885-002
AN  - 2008-10885-002
AU  - Grunberg, Neil E.
AU  - Greenwood, M. R. C.
AU  - Collins, Frank
AU  - Epstein, Leonard H.
AU  - Hatsukami, Dorothy
AU  - Niaura, Ray
AU  - O'Connell, Kathleen
AU  - Pomerleau, Ovide F.
AU  - Ravussin, Eric
AU  - Rolls, Barbara J.
AU  - Audrain, Janet
AU  - Coday, Mace
T1  - Task Force 1: Mechanisms relevant to the relations between cigarette smoking and body weight.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1992///
VL  - 11
IS  - Suppl
SP  - 4
EP  - 9
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-10885-002. PMID: 1396502 Partial author list: First Author & Affiliation: Grunberg, Neil E.; Uniformed Services University of the Health Sciences, US. Other Publishers: American Psychological Association. Release Date: 20080825. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Body Weight; Health Care Psychology; Smoking Cessation; Tobacco Smoking. Classification: Health Psychology & Medicine (3360). Population: Human (10). Page Count: 6. Issue Publication Date: 1992. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1992. 
AB  - This article resulted from several days of discussion regarding theories that may underlie the relation between cigarette smoking and body weight and the relation between smoking cessation and body weight. The working group composed of social and biological scientists who addressed this assignment considered what is already known within the smoking and body weight literature and also considered relevant findings from studies of smoking or body weight regulation that have not directly addressed the interaction of these variables. This article provides a synopsis of the deliberations of a working group charged with identifying worthwhile issues that will help determine mechanisms underlying the relation between smoking and body weight. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - body weight
KW  - cigarette smoking
KW  - smoking cessation
KW  - 1992
KW  - Body Weight
KW  - Health Care Psychology
KW  - Smoking Cessation
KW  - Tobacco Smoking
KW  - 1992
DO  - 10.1037/h0090345
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10885-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-10885-003
AN  - 2008-10885-003
AU  - Henningfield, Jack E.
AU  - Obarzanek, Eva
AU  - Benowitz, Neal L.
AU  - Hall, Sharon M.
AU  - Klesges, Robert C.
AU  - Leischow, Scott
AU  - Levin, Edward D.
AU  - Perkins, Kenneth A.
AU  - Spring, Bonnie
AU  - Stitzer, Maxine
AU  - Ward, Marcia C.
AU  - Winders, Suzan
AU  - Wood, Peter
AU  - Woods, Margo N.
AU  - Isbell, Terry
AU  - Klem, Mary L.
T1  - Task Force 2: Methods of assessment, strategies for research.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1992///
VL  - 11
IS  - Suppl
SP  - 10
EP  - 16
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-10885-003. PMID: 1396498 Partial author list: First Author & Affiliation: Henningfield, Jack E.; National Institute on Drug Abuse, US. Other Publishers: American Psychological Association. Release Date: 20080825. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Energy Expenditure; Food Intake; Measurement; Methodology; Nicotine. Minor Descriptor: Animal Models; Drug Administration Methods; Food Deprivation. Classification: Research Methods & Experimental Design (2260); Physiological Psychology & Neuroscience (2500). Population: Human (10); Animal (20). Page Count: 7. Issue Publication Date: 1992. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1992. 
AB  - In the present report, we address issues concerning the assessment of energy balance in human volunteers in laboratory and field settings. We then discuss issues and strategies in the assessment of nicotine intake in humans in laboratory and field settings, as well as different routes of nicotine administration. Last, we discuss laboratory animal models for studying these phenomena, including discussion of the advantages and disadvantages and recommended applications of the various animal models for assessments of energy balance, nicotine administration, and interactions among nicotine administration, food deprivation, and energy balance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - energy balance
KW  - nicotine intake
KW  - animal models
KW  - nicotine administration
KW  - food deprivation
KW  - assessment methods
KW  - 1992
KW  - Energy Expenditure
KW  - Food Intake
KW  - Measurement
KW  - Methodology
KW  - Nicotine
KW  - Animal Models
KW  - Drug Administration Methods
KW  - Food Deprivation
KW  - 1992
DO  - 10.1037/h0090340
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10885-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-85965-001
AN  - 1997-85965-001
AU  - Oshima, Iwao
AU  - Ueda, Hiroya
AU  - Yamazaki, Yoshihiko
AU  - Shiiya, Junji
T1  - Social perception toward the mentally disabled among general inhabitants who were against building public psychiatric emergency center in a new satellite town of Tokyo.
JF  - Journal of Mental Health
JO  - Journal of Mental Health
Y1  - 1992///
VL  - 38
SP  - 11
EP  - 23
CY  - Japan
PB  - National Inst of Mental Health - Japan
SN  - 0915-065X
N1  - Accession Number: 1997-85965-001. Partial author list: First Author & Affiliation: Oshima, Iwao; National Institute of Mental Health, Ichikawa, Japan. Release Date: 19970401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: Japanese. Major Descriptor: Emergency Services; Mental Disorders. Classification: Inpatient & Hospital Services (3379). Population: Human (10). Location: Japan. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: 1992. 
AB  - A plan to build a public psychiatric emergency center in a new satallite town of Tokyo resulted in a strong objection from the residents in several subdivisions. A survey of 700 samples was made to examine the background of the objection. The residents of the subdivisions which filed the objections were characterized as (a) having little experience of long-term illness and (b) having little contact with mentally challenged persons and senior citizens. (English abstract) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - background of objection to building of public psychiatric emergency center
KW  - residents
KW  - Japan
KW  - 1992
KW  - Emergency Services
KW  - Mental Disorders
KW  - 1992
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-85965-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-10885-004
AN  - 2008-10885-004
AU  - Gritz, Ellen R.
AU  - St. Jeor, Sachiko T.
AU  - Bennett, Glen
AU  - Biener, Lois
AU  - Blair, Steven N.
AU  - Bowen, Deborah J.
AU  - Brunner, Robert L.
AU  - DeHorn, Allan
AU  - Foreyt, John P.
AU  - Haire-Joshu, Deborah
AU  - Hall, Sharon M.
AU  - Hill, Dana Robin
AU  - Jensen, Joni
AU  - Kristeller, Jean
AU  - Marcus, Bess H.
AU  - Nides, Mitchell
AU  - Pirie, Phyllis L.
AU  - Solomon, Laura J.
AU  - Stillman, Frances
AU  - Ernst, John
AU  - Mealer, Cynthia Z.
T1  - Task Force 3: Implications with respect to intervention and prevention.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1992///
VL  - 11
IS  - Suppl
SP  - 17
EP  - 25
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-10885-004. PMID: 1396499 Partial author list: First Author & Affiliation: Gritz, Ellen R.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, US. Other Publishers: American Psychological Association. Release Date: 20080825. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Body Weight; Health Attitudes; Health Behavior; Smoking Cessation; Tobacco Smoking. Minor Descriptor: Intervention; Prevention; Weight Control. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Page Count: 9. Issue Publication Date: 1992. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1992. 
AB  - This article discusses three broad topics: (a) how beliefs about weight control influence smoking initiation and how preventive interventions might affect these beliefs, (b) whether weight gain affects smoking cessation and relapse, and (c) what primary gaps in our information still remain. Beliefs and behaviors relating to weight and their consequences were addressed within the contexts of smoking initiation, maintenance, cessation, and relapse. Special populations, application and evaluation of alternative interventions, and assessment of compliance were considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - weight control
KW  - smoking initiation
KW  - preventive interventions
KW  - weight gain
KW  - smoking cessation
KW  - relapse
KW  - health beliefs
KW  - health behaviors
KW  - 1992
KW  - Body Weight
KW  - Health Attitudes
KW  - Health Behavior
KW  - Smoking Cessation
KW  - Tobacco Smoking
KW  - Intervention
KW  - Prevention
KW  - Weight Control
KW  - 1992
DO  - 10.1037/h0090341
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10885-004&site=ehost-live&scope=site
UR  - ORCID: 0000-0002-5177-8520
UR  - 
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-85966-001
AN  - 1997-85966-001
AU  - Oshima, Iwao
T1  - Social Distance Scale and the attitude toward the mentally disabled among general inhabitants in megalopolis.
JF  - Journal of Mental Health
JO  - Journal of Mental Health
Y1  - 1992///
VL  - 38
SP  - 25
EP  - 37
CY  - Japan
PB  - National Inst of Mental Health - Japan
SN  - 0915-065X
N1  - Accession Number: 1997-85966-001. Partial author list: First Author & Affiliation: Oshima, Iwao; National Institute of Mental Health, Ichikawa, Japan. Release Date: 19970401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: Japanese. Major Descriptor: Mental Illness (Attitudes Toward); Rating Scales; Social Interaction; Test Validity. Classification: Psychometrics & Statistics & Methodology (2200); Psychological & Physical Disorders (3200). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: 1992. 
AB  - The validity of the Social Distance Scale, developed earlier by the National Institute of Mental Health, was examined by a mail survey of 1000 residents of Tokyo. The scores of the Scale were highly correlated with an attitude that mentally challenged persons are useless, dangerous and shameful. (English abstract) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - validity of Social Distance Scale & attitudes toward mentally disabled
KW  - residents
KW  - Japan
KW  - 1992
KW  - Mental Illness (Attitudes Toward)
KW  - Rating Scales
KW  - Social Interaction
KW  - Test Validity
KW  - 1992
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-85966-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-10885-006
AN  - 2008-10885-006
AU  - Pattishall, Evan G.
T1  - Smoking and body weight: Reactions and perspectives.
JF  - Health Psychology
JO  - Health Psychology
JA  - Health Psychol
Y1  - 1992///
VL  - 11
IS  - Suppl
SP  - 32
EP  - 33
CY  - US
PB  - Lawrence Erlbaum Associates
SN  - 0278-6133
SN  - 1930-7810
N1  - Accession Number: 2008-10885-006. PMID: 1396501 Partial author list: First Author & Affiliation: Pattishall, Evan G.; National Institute of Child Health and Human Development, US. Other Publishers: American Psychological Association. Release Date: 20080825. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Body Weight; Health Care Psychology; Smoking Cessation; Tobacco Smoking. Classification: Health Psychology & Medicine (3360). Population: Human (10). Page Count: 2. Issue Publication Date: 1992. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1992. 
AB  - Discusses papers resulting from the conference on smoking and body weight, which was conducted September 10 to 13, 1990, at Memphis State University, Memphis, Tennessee. The author comments on three areas; the first two are from the ideas that kept recurring throughout the conference, and the third is the author's own reaction or approach to the state of the art of behavior and health. The first issue relates to intraindividual variability. We should recognize and view the individual as a dynamic organism under transformation while awash in a sea of change. A second recurrent theme and concern during the conference was that multiple variables and multiple disciplines are involved in both smoking cessation and weight gain research. Yet, very few studies involve multiple variables and multiple disciplines. There appears to be a major gap in our theories, knowledge, methodology, technology and interventions, especially at the interaction level between multiple variables. Studying these kinds of interactions will involve a crucial effort to collaborate with multiple disciplines. We must continue to pursue this effort. It is the author's view that we must recognize and continue to document the perspective that behavior can be a major player in the basic biomedical and clinical science arena. The more we explore this perspective, the more we will be able to unravel and understand the basic dynamics and interactions of smoking and weight gain variables. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - smoking
KW  - body weight
KW  - smoking cessation
KW  - weight gain
KW  - 1992
KW  - Body Weight
KW  - Health Care Psychology
KW  - Smoking Cessation
KW  - Tobacco Smoking
KW  - 1992
DO  - 10.1037/h0090343
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10885-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-85967-001
AN  - 1997-85967-001
AU  - Fukui, Susumu
AU  - Wada, Kiyoshi
AU  - Ito, Masaomi
T1  - Dependency on organic solvents and aaits long-term prognosis.
JF  - Journal of Mental Health
JO  - Journal of Mental Health
Y1  - 1992///
VL  - 38
SP  - 39
EP  - 45
CY  - Japan
PB  - National Inst of Mental Health - Japan
SN  - 0915-065X
N1  - Accession Number: 1997-85967-001. Partial author list: First Author & Affiliation: Fukui, Susumu; National Institute of Mental Health, Ichikawa, Japan. Release Date: 19970401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: Japanese. Major Descriptor: Drug Dependency; Inhalant Abuse; Prognosis. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 7. Issue Publication Date: 1992. 
AB  - Surveyed 91 patients who had been hospitalized for solvent dependency and discharged 2–4 years prior to the date of the survey. Less than 30% of patients returned to normal life; others had no steady jobs. Some were hospitalized, imprisoned, missing or dead. About 70% showed some chronic symptoms, such as hallucinations, delusions, anxiety, inattention, and apathy. 36% still continued abusing solvents. Those who had been treated within 5 years of abuse showed relatively good prognosis. (English abstract) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - organic solvent dependency & long term prognosis
KW  - patients
KW  - 1992
KW  - Drug Dependency
KW  - Inhalant Abuse
KW  - Prognosis
KW  - 1992
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-85967-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09778-019
AN  - 2005-09778-019
AU  - Wagman, Althea M. I.
T1  - Report of a Workshop on Issues in Brain Tissue Acquisition.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1992///
VL  - 18
IS  - 1
SP  - 149
EP  - 153
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Wagman, Althea M. I., Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Ln., Rockville, MD, US, 20857
N1  - Accession Number: 2005-09778-019. Partial author list: First Author & Affiliation: Wagman, Althea M. I.; Clinical Neuroimaging and Electrophysiology Research Program, Schizophrenia Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051011. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Neurophysiology; Neuropsychiatry; Schizophrenia; Tissue Donation. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: 1992. 
AB  - In the recent past the National Institute of Mental Health (NIMH) has been interested in developing a research initiative to stimulate human brain research on the biological characteristics of schizophrenic brain tissue. The Schizophrenia Research Branch of the Division of Clinical Research of NIMH sponsored a workshop to study the issues of impediments to research on human brain tissue and develop recommendations for solving some of these problems. This article is the first implementation of one of these recommendations, that is, to provide information to the scientific community that brain tissue donations are important and that appropriate means must be taken in order for a donation to proceed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain tissue
KW  - schizophrenia
KW  - tissue donations
KW  - 1992
KW  - Brain
KW  - Neurophysiology
KW  - Neuropsychiatry
KW  - Schizophrenia
KW  - Tissue Donation
KW  - 1992
DO  - 10.1093/schbul/18.1.149
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09778-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09770-003
AN  - 2005-09770-003
AU  - Kirch, Darrell G.
AU  - Lieberman, Jeffrey A.
AU  - Matthews, Susan M.
T1  - First-Episode Psychosis: Part I. Editors' Introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1992///
VL  - 18
IS  - 2
SP  - 177
EP  - 178
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kirch, Darrell G., Division of Clinical Research, National Institute of Mental Health, Parklawn Bldg., Rm. 10-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09770-003. PMID: 1621066 Partial author list: First Author & Affiliation: Kirch, Darrell G.; Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051011. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Disease Course; Onset (Disorders); Psychosis; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: 1992. 
AB  - Until recently, there has been a conspicuous lack of studies regarding the earliest phases of psychotic illness, with most research on schizophrenia and related disorders focusing on chronically ill patients. Currently, however, a number of investigators have turned their attention toward this topic, exploring the conceptual issues involved in defining the onset of psychosis, using case registers and population-based samples to do crucial epidemiologic studies on the course of schizophrenia, and developing mechanisms for identifying patients with first-episode psychosis and entering them into active research protocols. The issue of the Schizophrenia Bulletin is devoted to articles representing this full range of conceptual and empirical work on first-episode psychosis. The ultimate goal is for researchers working in this area to develop a network to enhance the sharing of concepts and data, with the eventual possibility of developing combined data bases and collaborative studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - first episode psychosis
KW  - disease onset
KW  - disease course
KW  - schizophrenia
KW  - 1992
KW  - Disease Course
KW  - Onset (Disorders)
KW  - Psychosis
KW  - Schizophrenia
KW  - 1992
DO  - 10.1093/schbul/18.2.177
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09770-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09770-004
AN  - 2005-09770-004
AU  - Kirch, Darrell G.
AU  - Keith, Samuel J.
AU  - Matthews, Susan M.
T1  - Research on First-Episode Psychosis: Report on a National Institute of Mental Health Workshop.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1992///
VL  - 18
IS  - 2
SP  - 179
EP  - 184
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kirch, Darrell G., Division of Clinical Research, National Institute of Mental Health, Parklawn Bldg., Rm. 10-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2005-09770-004. PMID: 1621067 Partial author list: First Author & Affiliation: Kirch, Darrell G.; Division of Clinical Research, National Institute of Mental Health (NIMH), Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051011. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Mental Health; Psychosis. Minor Descriptor: Neuroleptic Drugs; Onset (Disorders); Relapse (Disorders). Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1992. 
AB  - The need to focus increased research on patients experiencing their first episode of psychosis was emphasized in A National Plan for Schizophrenia Research. To develop strategies for enhancing research in this area, a National Institute of Mental Health Workshop on First-Episode Psychosis was held in 1991. The topics discussed at that workshop are summarized, with key issues including the following: (1) the need for better operational definitions of onset, end of an episode, and relapse of psychosis; (2) careful consideration of inclusion and exclusion criteria related to age, gender, prior treatment, comorbid substance abuse, and similar issues; (3) the challenge of finding patients never exposed to neuroleptics and the value of entering first-episode patients into standardized treatment protocols; (4) the design of followup studies; (5) strategies to increase the pool of applicants; and (6) approaches for increasing power through data sharing and collaboration between groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - first episode psychosis
KW  - mental health workshop
KW  - research
KW  - disorder onset
KW  - relapse
KW  - neuroleptics
KW  - 1992
KW  - Experimentation
KW  - Mental Health
KW  - Psychosis
KW  - Neuroleptic Drugs
KW  - Onset (Disorders)
KW  - Relapse (Disorders)
KW  - 1992
DO  - 10.1093/schbul/18.2.179
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09770-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09766-003
AN  - 2005-09766-003
AU  - Lieberman, Jeffrey A.
AU  - Matthews, Susan M.
AU  - Kirch, Darrell G.
T1  - First-Episode Psychosis: Part II. Editors' Introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1992///
VL  - 18
IS  - 3
SP  - 349
EP  - 350
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Lieberman, Jeffrey A., Hillside Hospital-Long Island Jewish Medical Ctr., Albert Einstein College of Medicine, 75-59 263rd St., Glen Oaks, NY, US, 11004
N1  - Accession Number: 2005-09766-003. Partial author list: First Author & Affiliation: Lieberman, Jeffrey A.; Hillside Hospital-Long Island Jewish Medical Center, Albert Einstein College of Medicine, Glen Oaks, NY, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neuroleptic Drugs; Psychosis; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: 1992. 
AB  - The study of first-episode psychosis continues to gain momentum in the research community as evidenced by the range and diversity of topics addressed in both this issue and the previous issue of the Schizophrenia Bulletin (Vol. 18, No. 2). The examination of first-episode patients should provide further insight into the nature of schizophrenia and other illnesses in patients at the same stage of illness and before substantial neuroleptic exposure. These studies will also provide an opportunity to examine unique aspects or complications of the illness. The editors are deeply indebted to the researchers engaging in this extremely important area. We hope that the scientific progress, evident in these issues, will provide the basis by which to better understand the nature of mental illness and provide relief for patients and their families experiencing schizophrenia and related disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - first episode psychosis
KW  - schizophrenia bulletin
KW  - neuroleptic exposure
KW  - 1992
KW  - Neuroleptic Drugs
KW  - Psychosis
KW  - Schizophrenia
KW  - 1992
DO  - 10.1093/schbul/18.3.349
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Rising, Russell
AU  - Alger, Sharon
AU  - Boyce, Vicky
AU  - Seagle, Helen
AU  - Ferraro, Robert
AU  - Fontvieille, Anne Marie
AU  - Ravussin, Eric
T1  - Food intake measured by an automated food-selection system: relationship to energy expenditure.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/02//
VL  - 55
IS  - 2
M3  - Article
SP  - 343
EP  - 349
SN  - 00029165
AB  - Measuring food intake in a laboratory usually involves limited food choices. An automated food-selection system with two vending machines containing a large variety of foods was used to measure food intake in 10 male volunteers (31 ± 6 y, 69.2 ± 7.1 kg, 18 ± 7% fat, ¯ ± SD) on a metabolic ward. The effect of carbohydrate, fat, and protein intakes on 24-h energy expenditure (24EE) and substrate oxidations was measured in a respiratory chamber during day 4 of weight maintenance and day 7 of ad libitum intake. Ad libitum intake resulted in a 7-d overfeeding of 6468 ± 3824 kJ/d above weight-maintenance requirements, leading to a 2.3 ± 1.2-kg gain. The 10 975 ± 3774 kJ excess energy intake on day 7 of ad libitum intake caused a 1205 ± 920 kJ/d increase in 24EE (Δ24EE = 0.17 x Δintake - 695; r = 0.71, P < 0.02). Of the excess carbohydrate intake, 74% was oxidized (r = 0.86, P < 0.001), whereas excess fat intake was not. Carbohydrate and protein stores are regulated whereas excess fat intake is channeled to fat stores. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Food consumption
KW  - Energy metabolism
KW  - Food preferences
KW  - Caloric expenditure
KW  - Carbohydrate metabolism
KW  - energy expenditure
KW  - Food intake
KW  - nutrient oxidation
KW  - vending machines
N1  - Accession Number: 94402191; Rising, Russell 1; Alger, Sharon 1; Boyce, Vicky 1; Seagle, Helen 1; Ferraro, Robert 1; Fontvieille, Anne Marie 1; Ravussin, Eric 1; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes, Digestive Diseases, and Kidney Diseases, National Institutes of Health, Phoenix, AZ; Issue Info: Feb1992, Vol. 55 Issue 2, p343; Thesaurus Term: Food consumption; Thesaurus Term: Energy metabolism; Subject Term: Food preferences; Subject Term: Caloric expenditure; Subject Term: Carbohydrate metabolism; Author-Supplied Keyword: energy expenditure; Author-Supplied Keyword: Food intake; Author-Supplied Keyword: nutrient oxidation; Author-Supplied Keyword: vending machines; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Simopoulos, Artemis P.
AU  - Salem Jr., Norman
T1  - Egg yolk as a source of long-chain polyunsaturated fatty acids in infant feeding.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/02//
VL  - 55
IS  - 2
M3  - Article
SP  - 411
EP  - 414
SN  - 00029165
AB  - In this paper we compare the fatty acid content of egg yolks from hens fed four different feeds as a source of docosahexaenoic acid to supplement infant formula. Greek eggs contain more docosahexaenoic acid (DHA, 22:6ω3) and less linoleic acid (LA, l8:2ω6) and α-linolenic acid (LNA, 18:3ω3) than do fish-meal or flax eggs. Two to three grams of Greek egg yolk may provide an adequate amount of DHA and arachidonic acid for a preterm neonate. Mean intake of breast milk at age 1 mo provides 250 mg long-chain ω3 fatty acids. This amount can be obtained from < 1 yolk of a Greek egg (0.94), > 1 yolk of flax eggs (1.6) and fish-meal eggs (1.4), or 8.3 yolks of supermarket eggs. With proper manipulation of the hens' diets, eggs could be produced with fatty acid composition similar to that of Greek eggs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - Infants
KW  - Egg yolk
KW  - Unsaturated fatty acids
KW  - Docosahexaenoic acid -- Psychological aspects
KW  - Fish meal
KW  - ω3fatty acids
KW  - arachidonic acid
KW  - breast milk
KW  - Docosahexaenoic acid
KW  - eggyolks
KW  - infant formula
KW  - infant nutrition
KW  - preterm neonate
N1  - Accession Number: 94402193; Simopoulos, Artemis P. 1,2; Salem Jr., Norman 1,2; Affiliations: 1: Center for Genetics, Nutrition and Health, Washington, DC; 2: Laboratory of Membrane Biochemistry and Biophysics, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD; Issue Info: Feb1992, Vol. 55 Issue 2, p411; Thesaurus Term: HEALTH; Subject Term: Infants; Subject Term: Egg yolk; Subject Term: Unsaturated fatty acids; Subject Term: Docosahexaenoic acid -- Psychological aspects; Subject Term: Fish meal; Author-Supplied Keyword: ω3fatty acids; Author-Supplied Keyword: arachidonic acid; Author-Supplied Keyword: breast milk; Author-Supplied Keyword: Docosahexaenoic acid; Author-Supplied Keyword: eggyolks; Author-Supplied Keyword: infant formula; Author-Supplied Keyword: infant nutrition; Author-Supplied Keyword: preterm neonate; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Prentice, Andrew M.
AU  - Sonko, Bakary J.
AU  - Goldberg, Gail R.
AU  - Murgatroyd, Peter R.
AU  - Lands, William E. M.
AU  - Zakhari, Sam
AU  - Colditz, G. A.
AU  - Giovannucci, E.
AU  - Stampfer, E. B. Rimm M. J.
AU  - Rosner, B.
AU  - Speizer, F. E.
AU  - Willett, W. C.
T1  - The case of the missing calories revisited.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/02//
VL  - 55
IS  - 2
M3  - Letter to the Editor
SP  - 478
EP  - 480
SN  - 00029165
AB  - A letter to the editor is presented in response to a article related to alcohol intake in relation to diet and obesity in women and men by G. A. Colditz and others published in a 1991 issue of the periodical.
KW  - Alcohol -- Physiological effect
KW  - Obesity
N1  - Accession Number: 94402189; Prentice, Andrew M. 1; Sonko, Bakary J. 1; Goldberg, Gail R. 1; Murgatroyd, Peter R. 1; Lands, William E. M. 2; Zakhari, Sam 2; Colditz, G. A. 3; Giovannucci, E.; Stampfer, E. B. Rimm M. J.; Rosner, B.; Speizer, F. E.; Willett, W. C.; Affiliations: 1: MRC Dunn Clinical Nutrition Centre, 100 Tennis Court Road, Cambridge, CB2 1Q1, UK; 2: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism Alcohol, Drug Abuse and Mental Health Administration Public Health Service, Department of Health and Human Services Rockville, MD 20857; 3: Channing Laboratory, Department of Medicine Brigham and Women's Hospital, Harvard Medical School, 180 Longwood Avenue, Boston, MA 021 15-5899; Issue Info: Feb1992, Vol. 55 Issue 2, p478; Subject Term: Alcohol -- Physiological effect; Subject Term: Obesity; Number of Pages: 3p; Document Type: Letter to the Editor
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Foster, Willis R.
AU  - Burton, Benjamin T.
AU  - Hubbard, Van S.
T1  - Introduction.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/02//
VL  - 55
IS  - 2
M3  - Article
SP  - 487S
EP  - 487S
SN  - 00029165
AB  - An introduction is presented in which the editor discusses various reports within the issue on topics discussed at a conference of the U.S. National Institutes of Health on gastrointestinal surgery for severe obesity held in Bethesda, Maryland on March 25-27, 1991.
KW  - Gastrointestinal surgery
KW  - Obesity -- Surgery
N1  - Accession Number: 94402162; Foster, Willis R. 1; Burton, Benjamin T. 1; Hubbard, Van S. 1; Affiliations: 1: National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, MD; Issue Info: Feb1992, Vol. 55 Issue 2, p487S; Subject Term: Gastrointestinal surgery; Subject Term: Obesity -- Surgery; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Cuocolo, Alberto
AU  - Santomauro, Maurizio
AU  - Pace, Leonardo
AU  - Celentano, Luigi
AU  - Nappi, Antonio
AU  - Nicolai, Emanuele
AU  - Chiariello, Massimo
AU  - Salvatore, Marco
T1  - Comparison between exercise and trans-oesophageal atrial pacing in patients with coronary artery disease: technetium-99m methoxy isobutyl isonitrile simultaneous evaluation of ventricular function and myocardial perfusion.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1992/02//
VL  - 19
IS  - 2
M3  - Article
SP  - 119
EP  - 124
SN  - 03406997
N1  - Accession Number: 71144533; Cuocolo, Alberto 1 Santomauro, Maurizio 2 Pace, Leonardo 1 Celentano, Luigi 1 Nappi, Antonio 1 Nicolai, Emanuele 1 Chiariello, Massimo 2 Salvatore, Marco 3; Affiliation:  1: Department of Nuclear Medicine, Second Medical School, Università Federico II, Naples Italy  2: Department of Cardiology, Second Medical School, Università Federico II, Naples Italy  3: National Cancer Institute, Naples Italy; Source Info: Feb1992, Vol. 19 Issue 2, p119; Number of Pages: 6p; Document Type: Article
L3  - 10.1007/BF00184127
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Xu, R.
AU  - Burdick, J. F.
AU  - Scott, A.
AU  - Beschorner, W. E.
AU  - Adler, W.
AU  - Kittur, D. S.
T1  - Graft-specific MHC class II gene expression in response to allogeneic stimulus in heterotopic murine cardiac allografts.
JO  - Immunology
JF  - Immunology
Y1  - 1992/02//
VL  - 75
IS  - 2
M3  - Article
SP  - 361
EP  - 365
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Although, major histocompatibility complex (MHC) class H antigen expression in allografts is thoroughly studied, regulation of the genes for these antigens is not fully understood. The graft-specific MHC class II genes are potentially important in determining the immunogenicity of graft but their detection in a mixed-cell `population such as in the allograft would require unambiguous differentiation of graft-specific class II expression from those in host lymphoid cells. With an oligonucleotide probe that specifically hybridizes to I-Ab mRNA from He2k haplotype mice, we have studied I-A gene expression in cardiac allografts heterotopically transplanted from B10.Br (H2k) to B10.D2 (H-22) mice. Normal B10.Br hearts do not have appreciable I-Ab transcripts as determined with this probe, but 4 days after allografting, a substantial increase in I-Abk messenger RNA (mRNA) content was noted in the allografted hearts which persisted for the next 2 days and then decreased concomitant with destruction of the heart. The increase in I-Abk mRNA preceded the expression of surface lak antigens on dendritic and endothelial cells in the allograft. These data indicate increased transcription of the 1-Ab gene in cells of graft origin suggesting that transcriptional regulation is the initial mechanism for expression of class II genes in allografts. The sustained rise in grail-specific class 11 mRNA also seen in these allografts suggests that increased mRNA stability may be another mechanism for the increased density of class II antigens in allografts undergoing rejection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTOCOMPATIBILITY
KW  - TRANSPLANTATION immunology
KW  - HOMOGRAFTS
KW  - IMMUNOGLOBULINS
KW  - GENE expression
KW  - GENETIC regulation
N1  - Accession Number: 14074245; Xu, R. 1 Burdick, J. F. 1 Scott, A. 2 Beschorner, W. E. 3 Adler, W. 4 Kittur, D. S. 3; Affiliation:  1: Department of Surgery,  Johns Hopkins University School of Medicine, Baltimore, Maryland. U.S.A.  2: Department of Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland. U.S.A.  3: Department of Pathology,  Johns Hopkins University School of Medicine, Baltimore, Maryland. U.S.A.  4: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Maryland. U.S.A.; Source Info: Feb92, Vol. 75 Issue 2, p361; Subject Term: HISTOCOMPATIBILITY; Subject Term: TRANSPLANTATION immunology; Subject Term: HOMOGRAFTS; Subject Term: IMMUNOGLOBULINS; Subject Term: GENE expression; Subject Term: GENETIC regulation; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kohn, William G.
AU  - Ship, Jonathan A.
AU  - Atkinson, Jane C.
AU  - Patton, Lauren L.
AU  - Fox, Phillip C.
AU  - Kohn, W G
AU  - Ship, J A
AU  - Atkinson, J C
AU  - Patton, L L
AU  - Fox, P C
T1  - Salivary gland 99mTc-scintigraphy: a grading scale and correlation with major salivary gland flow rates.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1992/02//
VL  - 21
IS  - 2
M3  - journal article
SP  - 70
EP  - 74
SN  - 09042512
AB  - Sequential salivary gland scintigraphy with 99mTc-technetium pertechnetate (Tc-99) is a safe, minimally invasive test for study of major salivary glands. However, its relationship to salivary function has not been investigated in detail. We have investigated the relationship between major salivary gland flow rates and Tc-99 scans and developed a new rating scale using scans of a control group with normal salivary function. Salivary flow rates and Tc-99 scans were obtained from healthy, non-medicated subjects (n = 33) and from xerostomic patients (n = 22). There were significant differences between the groups for salivary flow rates and Tc-99 ratings. Significant correlations were found between salivary flow rates and Tc-99 ratings in the control and xerostomic groups. The Tc-99 rating scale proved reliable in assessing salivary dysfunction, and showed a high inter-examiner correlation. These results demonstrate the usefulness of salivary gland scintigraphy in assessing major salivary gland flow rates and the utility of a new rating scale. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SALIVARY glands
KW  - SALIVA
KW  - SUBMANDIBULAR gland
KW  - TECHNETIUM compounds
N1  - Accession Number: 11476404; Kohn, William G. 1 Ship, Jonathan A. 1 Atkinson, Jane C. 1 Patton, Lauren L. 1 Fox, Phillip C. 1 Kohn, W G 2 Ship, J A Atkinson, J C Patton, L L Fox, P C; Affiliation:  1: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, USA  2: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892; Source Info: Feb1992, Vol. 21 Issue 2, p70; Subject Term: SALIVARY glands; Subject Term: SALIVA; Subject Term: SUBMANDIBULAR gland; Subject Term: TECHNETIUM compounds; Number of Pages: 5p; Document Type: journal article
L3  - 10.1111/1600-0714.ep11476404
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rayhan, R.
AU  - Xu, L.
AU  - Santarpb III, R. P.
AU  - Tylenda, C. A.
AU  - Pollock, J. J.
T1  - Antifungal activities of salivary histidine-rich polypeptides against <em>Candida albicans</em> and other oral yeast isolates.
JO  - Oral Microbiology & Immunology
JF  - Oral Microbiology & Immunology
Y1  - 1992/02//
VL  - 7
IS  - 1
M3  - Article
SP  - 51
EP  - 52
SN  - 09020055
AB  - Twenty-six oral yeast isolates from 26 donors were tested fat threw susceptibility to salivary histidine-rich polypeptide-4 (HRP-4) in blastospore viability assays. HRP-4 was observed to inhibit blastospore division in all of the yeast isolates, although inhibition was variable depending upon both species and strain tested. Nine species of <em>Candida</em>and 2 strains of <em>Trichosporon pullulans</em> were included in the study. No significant differences in susceptibility to HRP-4 could be seen, irrespective of where in the oral cavity the yeast isolate was obtained. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oral Microbiology & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Blastomycetes
KW  - Antifungal agents
KW  - Yeast
KW  - Feasibility studies
KW  - Peptide hormones
KW  - Candida
KW  - <em>Candida albicans</em>
KW  - antifungal
KW  - histidine-rich polypeptide
KW  - saliva
N1  - Accession Number: 12546919; Rayhan, R. 1; Xu, L. 1; Santarpb III, R. P. 1; Tylenda, C. A. 2; Pollock, J. J. 1; Affiliations: 1: Department ot Oral Biology arid Pathology, School of Dental Medicine. State University of New York at Stony Brook; 2: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA; Issue Info: Feb1992, Vol. 7 Issue 1, p51; Thesaurus Term: Blastomycetes; Thesaurus Term: Antifungal agents; Subject Term: Yeast; Subject Term: Feasibility studies; Subject Term: Peptide hormones; Subject Term: Candida; Author-Supplied Keyword: <em>Candida albicans</em>; Author-Supplied Keyword: antifungal; Author-Supplied Keyword: histidine-rich polypeptide; Author-Supplied Keyword: saliva; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1399-302X.ep12546919
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Zamudio, Fernando
AU  - Saavedra, Rafael
AU  - Martin, Brian Michael
AU  - Gurrola-Briones, Georgina
AU  - Hérion, Pascal
AU  - Possani, Lourival Domingos
T1  - Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion <em>Centruroides noxius</em> Hoffmann.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1992/02/15/
VL  - 204
IS  - 1
M3  - Article
SP  - 281
EP  - 292
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Two toxins, which we propose to call toxins 2 and 3, were purified to homogeneity from the venom of the scorpion Centruroides noxius Hoffmann. The full primary structures of both peptides (66 amino acid residues each) was determined. Sequence comparison indicates that the two new toxins display 79% identity and present a high similarity to previously characterized Centruroides toxins, the most similar toxins being Centruroides suffusus toxin 2 and Centruroides limpidus tecomanus toxin 1. Six monoclonal antibodies (mAb) directed against purified fraction II- 9.2 (which contains toxins 2 and 3) were isolated in order to carry out the immunochemical characterization of these toxins. mAb BCF2, BCF3, BCF7 and BCF9 reacted only with toxin 2, whereas BCF1 and BCF8 reacted with both toxins 2 and 3 with the same affinity. Simultaneous binding of mAb pairs to the toxin and cross-reactivity of the venoms of different scorpions with the mAb were examined. The results of these experiments showed that the mAb define four different epitopes (A- D). Epitope A (BCF8) is topographically unrelated to epitopes B (BCF2 and BCF7), C (BCF3) and D (BCF9) but the latter three appear to be more closely related or in close proximity to each other. Epitope A was found in all Centruroides venoms tested as well as on four different purified toxins of C. noxius, and thus seems to correspond to a highly conserved structure. Based on the cross-reactivity of their venoms with the mAb, Centruroides species could be classified in the following order: Centruroides elegans, Centruroides suffusus = Centruroides infamatus infamatus, Centruroides limpidus tecomanus, Centruroides limpidus limpidus, and Centruroides limpidus acatlanensis, according to increasing immunochemical relatedness of their toxins to those of Centruroides noxius. Ali six mAb inhibited the binding of toxin 2 to rat brain synaptosomal membranes, but only mAb BCF2, which belongs to the IgG2a subclass, displayed a clear neutralizing activity in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOXINS
KW  - IMMUNOGLOBULINS
KW  - PLASMA cells
KW  - BLOOD proteins
KW  - CENTRUROIDES
KW  - BIOCHEMISTRY
KW  - MOLECULAR biology
N1  - Accession Number: 13778173; Zamudio, Fernando 1 Saavedra, Rafael 2 Martin, Brian Michael 3 Gurrola-Briones, Georgina 1 Hérion, Pascal 2 Possani, Lourival Domingos 1; Affiliation:  1: Departamento de Bioquímica, Instituto de Biotecnología, Universidad Autónoma de México, Cuernavaca, México  2: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Autónoma de México, Ciudad Universitaria, México City, México  3: National Institute of Mental Health, Section on Molecular Neurogenetics, Clinical Neuroscience Branch, National Institutes of Health, Bethesda, USA; Source Info: 2/15/92, Vol. 204 Issue 1, p281; Subject Term: TOXINS; Subject Term: IMMUNOGLOBULINS; Subject Term: PLASMA cells; Subject Term: BLOOD proteins; Subject Term: CENTRUROIDES; Subject Term: BIOCHEMISTRY; Subject Term: MOLECULAR biology; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wilcox, Allen J.
AU  - Skjærven, Rolv
T1  - Birth Weight and Perinatal Mortality: The Effect of Gestational Age.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/03//
VL  - 82
IS  - 3
M3  - Article
SP  - 378
EP  - 382
PB  - American Public Health Association
SN  - 00900036
AB  - Background. The strong association between birth weight and perinatal mortality is due both to gestational age and to factors unrelated to gestational age. Conventional analysis obscures these separate contributions to perinatal mortality, and overemphasizes the role of birth weight. An alternative approach is used here to separate gestational age from other factors. Methods. Data are from 400 000 singleton births in the Norwegian Medical Birth Registry. The method of Wilcox and Russell is used to distinguish the contributions to perinatal mortality made by gestational age and by relative birth weight at each gestational age. Results. Gestational age is a powerful predictor of birth weight and perinatal survival. After these effects of gestational age are controlled for, relative birth weight retains a strong association with survival. Conclusions. Current public health policies in the United States emphasize the prevention of low birth weight. The present analysis suggests that the prevention of early delivery would benefit babies of all birth weights. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BIRTH weight
KW  - PERINATAL death
KW  - GESTATIONAL age
KW  - PUBLIC health -- United States
KW  - LOW birth weight
KW  - UNITED States
N1  - Accession Number: 9207131688; Wilcox, Allen J. 1 Skjærven, Rolv 2; Affiliation:  1: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC  2: Section for Medical Informatics and Statistics, University of Bergen, Bergen, Norway; Source Info: Mar1992, Vol. 82 Issue 3, p378; Subject Term: BIRTH weight; Subject Term: PERINATAL death; Subject Term: GESTATIONAL age; Subject Term: PUBLIC health -- United States; Subject Term: LOW birth weight; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Overpeck, Mary D.
AU  - Hoffman, Howard J.
AU  - Prager, Kate
T1  - The Lowest Birth-Weight Infants and the US Infant Mortality Rate: NCHS 1983 Linked Birth/Infant Death Data.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/03//
VL  - 82
IS  - 3
M3  - Article
SP  - 441
EP  - 444
PB  - American Public Health Association
SN  - 00900036
AB  - The National Center for Health Statistics Linked Birth and Infant Death Data Set, 1983 birth cohort, shows that infants weighing less than 750 g, comprising only 0.3% of all births, account for 25% of deaths in the first week. If interventions had prevented the death of these very small babies, the infant mortality rate would have been 8.3 per 1000 live births instead of 10.9, and the Black/White mortality differential would have been reduced by 25%. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LOW birth weight
KW  - PREMATURE infants
KW  - INFANTS -- Death
KW  - INFANT mortality
KW  - UNITED States
KW  - NATIONAL Center for Health Statistics (U.S.)
N1  - Accession Number: 9207131704; Overpeck, Mary D. 1 Hoffman, Howard J. 1 Prager, Kate 2; Affiliation:  1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda  2: National Center for Health Statistics, Centers for Disease Control, Hyattsville; Source Info: Mar1992, Vol. 82 Issue 3, p441; Subject Term: LOW birth weight; Subject Term: PREMATURE infants; Subject Term: INFANTS -- Death; Subject Term: INFANT mortality; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Patterson, Blossom H.
AU  - Block, Gladys
T1  - Patterson and Block Respond.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/03//
VL  - 82
IS  - 3
M3  - Letter
SP  - 466
EP  - 466
PB  - American Public Health Association
SN  - 00900036
AB  - A response by Blossom H. Patterson and Gladys Block to a letter to the editor about their article "Fruits and Vegetables in the American Diet: Data From the NHANES II Survey" in the December 1990 issue is presented.
KW  - LETTERS to the editor
KW  - DIET
N1  - Accession Number: 22487324; Patterson, Blossom H. 1 Block, Gladys 1; Affiliation:  1: National Cancer Institute; Source Info: Mar1992, Vol. 82 Issue 3, p466; Subject Term: LETTERS to the editor; Subject Term: DIET; Number of Pages: 2/5p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Manohar, V.
AU  - Brown, E.M.
AU  - Chused, T.M.
T1  - Murine splenic null cell compartment contains distinct haemopoietic subpopulations: enlargement of a myeloid and an indifferentiated subset with the development of splenomegaly in New Zealand black mice.
JO  - Immunology
JF  - Immunology
Y1  - 1992/03//
VL  - 75
IS  - 3
M3  - Article
SP  - 448
EP  - 455
PB  - Wiley-Blackwell
SN  - 00192805
AB  - We have previously reported that non-T, non-B 'null' cells increase with age in New Zealand Black (NZB) mice resulting in splenomegaly. Using a panel of monoclonal antibodies recognizing lineage-specific cell surface antigens we demonstrate four distinct subsets within this null cell compartment: (1) undifferentiated: (2) T lineage with undetectable Thy-1.2; (3) myeloid/erythroid: and (4) a pre-B/ plasma cell type. All four subsets also occur in non-autoimmune mice. The frequency of these populations arc similar in the young mice of all the strains examined, although the total number of null cells is higher in NZB. The elevation of null cells in young NZB mice is controlled by a single dominant gene in the genetic cross with New Zealand White (NZW) mice and does not appear closely related to the subsequent development of autoimmune disease. The proportion of mycloid/erythroid null cells increases with age in NZB as splenomegaly develops. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - MONOCLONAL antibodies
KW  - CELL surface antigens
KW  - HEMATOPOIETIC system
KW  - AUTOIMMUNE diseases
KW  - PLASMA cells
N1  - Accession Number: 13395976; Manohar, V. 1 Brown, E.M. 2 Chused, T.M. 2; Affiliation:  1: Laboratory of Cell Biology, Division of Hematology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, National Institute of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1992, Vol. 75 Issue 3, p448; Subject Term: CELLS; Subject Term: MONOCLONAL antibodies; Subject Term: CELL surface antigens; Subject Term: HEMATOPOIETIC system; Subject Term: AUTOIMMUNE diseases; Subject Term: PLASMA cells; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Hodes, L
T1  - Limits of classification. Part 2. Comment on Lawson and Jurs
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1992/03//
VL  - 32
IS  - 2
M3  - Article
SP  - 157
EP  - 166
SN  - 00952338
AB  - Lawson and Jurs have two recent papers on clustering using data on a diverse set of 143 published acrylates. From work on clustering large diverse sets of compounds, it has been found that a diverse set of compounds will generally have a dual nature--some clustered and some scattered compounds. The author discusses whether the five published clusters are a good classification of that set of compounds. A further analysis provides insight into the interrelations among the acrylates.
KW  - CHEMISTRY
KW  - CLASSIFICATION
KW  - CLUSTER analysis
KW  - Chemical data
N1  - Accession Number: ISTA2701519; Hodes, L 1; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: Mar 1992, Vol. 32 Issue 2, p157; Note: Update Code: 2700; Subject Term: CHEMISTRY; Subject Term: CLASSIFICATION; Subject Term: CLUSTER analysis; Author-Supplied Keyword: Chemical data; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Scott, Bettina M.
AU  - Denniston, Robert W.
AU  - Magruder, Kathryn M.
T1  - ALCOHOL ADVERTISING IN THE AFRICAN-AMERICAN COMMUNITY.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1992///Spring92
VL  - 22
IS  - 2
M3  - Article
SP  - 455
EP  - 469
SN  - 00220426
AB  - Beverage alcohol is the most widely used, enjoyed, and abused addictive substance in the United States. Alcohol related problems -- which range from alcoholism, cirrhosis, trauma, and criminal behavior to birth defects, cancer, and other long-term health problems -- result in an estimated 100,000 deaths and cost the American society more than $135 billion each year. Alcohol abuse is the leading health and safety problem in the African-American community, making its health and social consequences especially severe. Given this backdrop, there are compelling reasons to be concerned when alcohol producers target African Americans with special advertising and promotions. It is important to examine the marketing and advertising practices of alcohol producers as they relate to African-American communities and their potential impact on alcohol-related behaviors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOLIC beverages
KW  - ALCOHOLISM
KW  - CIRRHOSIS of the liver
KW  - CANCER
KW  - ADVERTISING
N1  - Accession Number: 9210193537; Scott, Bettina M. 1 Denniston, Robert W. 1 Magruder, Kathryn M. 2; Affiliation:  1: Division of Communication Programs, Office for Substance Abuse Prevention, Rockville, MD.  2: Division of Applied and Services Research, Services Research Branch, National Institute of Mental Health, Rockville, MD.; Source Info: Spring92, Vol. 22 Issue 2, p455; Subject Term: ALCOHOLIC beverages; Subject Term: ALCOHOLISM; Subject Term: CIRRHOSIS of the liver; Subject Term: CANCER; Subject Term: ADVERTISING; NAICS/Industry Codes: 541850 Outdoor Advertising; NAICS/Industry Codes: 541890 Other Services Related to Advertising; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 312140 Distilleries; Number of Pages: 15p; Document Type: Article; Full Text Word Count: 6311
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenthal, Dean S.
AU  - Griffiths, Christopher E. M.
AU  - Yuspa, Stuart H.
AU  - Roop, Dennis R.
AU  - Voorhees, John J.
T1  - Acute or Chronic Topical Retinoic Acid Treatment of Human Skin In Vivo Alters the Expression of Epidermal Transglutaminase, Loricrin, Involucrin, Filaggrin, and Keratins 6 and 13 but not Keratins 1, 10, and 14.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/03//
VL  - 98
IS  - 3
M3  - Article
SP  - 343
EP  - 350
SN  - 0022202X
AB  - Histologic and immunocytochemical analyses were performed on cutaneous biopsies from 10 patients treated with retinoic acid under occlusion for 4 d compared to biopsies from 19 patients treated nightly for 16 weeks. Acute application of RA caused epidermal thickening (9 of 10 samples), stratum granulosum thickening (7 of 10), parakeratosis (4 of 10). a marked increase in the number of cell layers expressing epidermal transglutaminase (7 of 10), and focal expression of two non-epidermal keratins. K6 (8 of I0) and K13 (2 of I0), changes also observed with chronic treatment, Involucrin, filaggrin, and Ioricrin were also altered in samples from both acute and chronic treatment. An increased number of cell layers expressed both involucrin and filaggrin from both the acute (7 of I0) and chronic (14 of 19) treatment groups. In the acute group, loricrin expression was significantly reduced or absent in some regions of the epidermis (5 of 10). whereas most chronic samples showed an increased number of cell layers expressing loricrin (12 of 19). The pattern of expression of three major epidermal differentiation products, keratins K 1, K10, and K14, was not significantly altered in any of the acute or chronic samples. although there was a slight reduction in the detection of K10 in two of the acute samples. Thus, acute topical RA treatment under occlusion caused substantial changes in the epidermis, and reproduced most, but not all of the effects of Chronic treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRETINOIN
KW  - CLINICAL pathology
KW  - BIOPSY
KW  - EPIDERMIS
KW  - EPITHELIUM
KW  - TRANSGLUTAMINASES
KW  - SKIN
N1  - Accession Number: 12499802; Rosenthal, Dean S. 1 Griffiths, Christopher E. M. 2 Yuspa, Stuart H. 1 Roop, Dennis R. 3 Voorhees, John J. 2; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland.  2: Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.  3: Department of Cell Biology and Dermatology, Baylor College of Medicine, Houston, Texas.; Source Info: Mar1992, Vol. 98 Issue 3, p343; Subject Term: TRETINOIN; Subject Term: CLINICAL pathology; Subject Term: BIOPSY; Subject Term: EPIDERMIS; Subject Term: EPITHELIUM; Subject Term: TRANSGLUTAMINASES; Subject Term: SKIN; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12499802
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Michel, Serge
AU  - Bernerd, Francoise
AU  - Jetten, Anton M.
AU  - Floyd, Elisabeth E.
AU  - Shroot, Braham
AU  - Reichert, Uwe
T1  - Expression of Keratinocyte Transglutamine mRNA Revealed by In Situ Hybridization.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/03//
VL  - 98
IS  - 3
M3  - Article
SP  - 364
EP  - 368
SN  - 0022202X
AB  - Plasma membrane-bound transglutaminase (TGm) catalyzes the formation of cornified envelopes (CE) in terminally differentiating keratinocytes. The recent cloning of cDNA encoding rabbit TGm allows detailed studies of its gene ex- pression and regulation. In the present paper, we describe the localization of TGm mRNA in rabbit tissues, as well as in normal and psoriatic human skin, as assessed by in situ hybridization. Furthermore, we correlate TGm mRNA localization with the distribution of the TGm protein detected by immunohistochemistry with a specific monoclonal antibody. In rabbit epidermis, TGm mRNA was expressed in supra- basal cells. The TGm protein was detected in the upper stratum spinosum and stratum granulosum. In rabbit esophagus, TGm rnRNA and protein were already expressed to a high level in the first suprabasal cell layer, and their expression decreased in the more differentiated cells. In normal human skin, a small amount of TGm mRNA, restricted to the stratum granulosum, was found, whereas psoriatic skin samples contained high amounts of TGm mRNA in the suprabasal layers with a decreasing gradient into the rete ridges, i.e., the involutions of the epidermis into the dermal compartment. The TGrn protein was absent from the rete ridges and con- fined to several cell layers expressing high levels of mRNA. There was virtually no difference between uninvolved psoriatic and normal epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - MESSENGER RNA
KW  - EPIDERMIS
KW  - CELL membranes
KW  - GENETIC engineering
KW  - HYBRIDIZATION
N1  - Accession Number: 12499806; Michel, Serge 1 Bernerd, Francoise 1 Jetten, Anton M. 2 Floyd, Elisabeth E. 2 Shroot, Braham 1 Reichert, Uwe 1; Affiliation:  1: Centre International de Recherches Dermatologiques GALDERMA (CIRD GALDERMA), Sophia Antipolis, Valbonne, France.  2: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S.A.; Source Info: Mar1992, Vol. 98 Issue 3, p364; Subject Term: KERATINOCYTES; Subject Term: MESSENGER RNA; Subject Term: EPIDERMIS; Subject Term: CELL membranes; Subject Term: GENETIC engineering; Subject Term: HYBRIDIZATION; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12499806
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - RPRT
AU  - Uitto, Jouni
AU  - Bauer, Eugene A.
AU  - Moshell, Alan N.
T1  - Symposium on Epidermolysis Bullosa: Molecular Biology and Pathology of the Cutaneous Basement Membrane Zone.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/03//
VL  - 98
IS  - 3
M3  - Report
SP  - 391
EP  - 395
SN  - 0022202X
AB  - This article focuses on a symposium on Epidermolysis bullosa, molecular biology and pathology of the cutaneous basement membrane zone. Epidermolysis bullosa is a group of perhaps as many as 20 hereditary diseases of the skin that share the common feature of the formation of blisters and erosions in response to minor trauma. To determine the molecular basis of the defect in the keratin filaments, the group has explored the specific mutations in two EB herpetiformis patients. In each of the patients, they found a point mutation in codon 125, which normally encodes an arginine.
KW  - CONFERENCES & conventions
KW  - MOLECULAR biology
KW  - BIOCHEMISTRY
KW  - PREVENTIVE medicine
KW  - GENETIC disorders
KW  - AMINO acids
N1  - Accession Number: 12499822; Uitto, Jouni 1,2,3 Bauer, Eugene A. 4 Moshell, Alan N. 5; Affiliation:  1: Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.  2: Section of Molecular Dermatology, Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.  3: Departments of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.  4: Department of Dermatology, Stanford University School of Medicine, Stanford, California.  5: Skin Disease Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, U.S.A.; Source Info: Mar1992, Vol. 98 Issue 3, p391; Subject Term: CONFERENCES & conventions; Subject Term: MOLECULAR biology; Subject Term: BIOCHEMISTRY; Subject Term: PREVENTIVE medicine; Subject Term: GENETIC disorders; Subject Term: AMINO acids; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 5p; Document Type: Report
L3  - 10.1111/1523-1747.ep12499822
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kohn, W. G.
AU  - Grossman, E.
AU  - Fox, P. C.
AU  - Armando, I.
AU  - Goldstein, D. S.
AU  - Baum, B. J.
T1  - Effect of ionizing radiation on sympathetic nerve function in rat parotid glands.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1992/03//
VL  - 21
IS  - 3
M3  - Article
SP  - 134
EP  - 137
SN  - 09042512
AB  - Ionizing radiation (IR) irreversibly damages salivary glands. The pathologic mechanism is unknown. Previously we reported that parotid serous acinar cells may not be the primary site of damage by IR. The purpose of this study was to determine if IR alters sympathetic nerve function in rat parotid glands. Male adult rats received a single dose of radiation (20 Gy) to the head and neck. Three days after IR, parotid saliva secretion induced by norepinephrine (NE) was completely blocked. Catecholamine uptake and metabolism were studied by injecting [[SUP3]H] dopamine ([[SUP3]DA) into irradiated rats, as a bolus. After 60 min, animals were sacrificed and the parotid gland, submandibular gland, and left ventricle removed. Tissue contents of [[SUP3]H]DA and [3H]NE, identified by HPLC, were unaffected by IR. The results indicate that IR abolishes acinar responsiveness to NE without affecting parotid sympathetic nerve function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PAROTID glands
KW  - IONIZING radiation
KW  - NORADRENALINE
KW  - CATECHOLAMINES
KW  - DOPAMINE
KW  - dopamine
KW  - ionizing radiation
KW  - norepinephrine
KW  - parotid gland
KW  - saliva secretion
KW  - sympathetic innervation.
N1  - Accession Number: 11614946; Kohn, W. G. 1 Grossman, E. 2 Fox, P. C. Armando, I. 2 Goldstein, D. S. 2 Baum, B. J. 1; Affiliation:  1: Clinical  investigations and Patient Care  Branch, National Institute of Dental Research, National Institute of Health Bethesda,  Maryland, USA.  2: Clinical  Neurosciences  Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda,  Maryland, USA.; Source Info: Mar1992, Vol. 21 Issue 3, p134; Subject Term: PAROTID glands; Subject Term: IONIZING radiation; Subject Term: NORADRENALINE; Subject Term: CATECHOLAMINES; Subject Term: DOPAMINE; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: ionizing radiation; Author-Supplied Keyword: norepinephrine; Author-Supplied Keyword: parotid gland; Author-Supplied Keyword: saliva secretion; Author-Supplied Keyword: sympathetic innervation.; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1600-0714.ep11614946
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104741928
T1  - Diclofenac does not modify morphine bioavailability in cancer patients.
AU  - De Conno, F
AU  - Ripamonti, C
AU  - Bianchi, M
AU  - Ventafridda, V
AU  - Panerai, A E
Y1  - 1992/03//1992 Mar
N1  - Accession Number: 104741928. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Diclofenac -- Adverse Effects
KW  - Morphine -- Pharmacokinetics
KW  - Neoplasms -- Metabolism
KW  - Pain -- Metabolism
KW  - Aged
KW  - Biological Availability
KW  - Chromatography, High Pressure Liquid
KW  - Drug Interactions
KW  - Time
KW  - Middle Age
KW  - Morphine -- Therapeutic Use
KW  - Neoplasms -- Physiopathology
KW  - Pain -- Drug Therapy
KW  - Pain -- Etiology
SP  - 401
EP  - 402
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 48
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy.
U2  - PMID: 1594262.
DO  - 10.1016/0304-3959(92)90091-O
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Putnam, Lois E.
AU  - Johnson Jr., Ray
AU  - Roth, Walton T.
T1  - Guidelines for Reducing the Risk of Disease Transmission in the Psychophysiology Laboratory.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1992/03//
VL  - 29
IS  - 2
M3  - Article
SP  - 127
EP  - 141
SN  - 00485772
AB  - The acquired immunodeficiency syndrome (AIDS) pandemic has highlighted the need for safeguards against the inadvertent transmission of Infectious disease in the psychophysiology laboratory. These Guidelines identify factors contributing to the risk of bloodborne disease transmission to subjects or technicians, and recommend procedures to minimize such risk, given current knowledge and techniques. The lowest risk is associated with the application of devices, such as surface electrodes, to non-abraded, intact skin. Such devices should be clean, but do not require disinfection. The potential risk of infection is higher when surface electrodes are applied to non-intact skin. Abrasion, or other breaks in the skin, can allow seepage of blood products carrying such pathogens as hepatitis B virus and the human Immunodeficiency virus that causes AIDS. Thus electrodes require high-level disinfection before reuse on non-intact skin. In addition, technicians should wear gloves during skin preparation and should abrade the skin no more than necessary, using only sterile, preferably non-sharp materials. The highest risk Is that associated with items that enter sterile tissue, such as subdermal electrodes and the needles and lancets sometimes used in skin preparation. Such Items must be sterile at the time of use and must be handled with extreme caution. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease)
KW  - COMMUNICABLE diseases -- Transmission
KW  - BLOODBORNE infections
KW  - DISEASES -- Risk factors
KW  - DISINFECTION & disinfectants
KW  - HEPATITIS
KW  - AIDS
KW  - Disinfection
KW  - Hepatitis.
KW  - Laboratory safety. Disease transmission. Psychophysiology. Electrodes
N1  - Accession Number: 11050995; Putnam, Lois E. 1 Johnson Jr., Ray 2 Roth, Walton T. 3; Affiliation:  1: Columbia University  2: National Institutes of Health  3: Stanford University Medical Center; Source Info: Mar1992, Vol. 29 Issue 2, p127; Subject Term: AIDS (Disease); Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: BLOODBORNE infections; Subject Term: DISEASES -- Risk factors; Subject Term: DISINFECTION & disinfectants; Subject Term: HEPATITIS; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: Disinfection; Author-Supplied Keyword: Hepatitis.; Author-Supplied Keyword: Laboratory safety. Disease transmission. Psychophysiology. Electrodes; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 15p; Document Type: Article
L3  - 10.1111/1469-8986.ep11050995
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104740073
T1  - Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia.
AU  - Jacobs, T P
AU  - Kempski, O
AU  - McKinley, D
AU  - Dutka, A J
AU  - Hallenbeck, J M
AU  - Feuerstein, G
Y1  - 1992/03//1992 Mar
N1  - Accession Number: 104740073. Language: English. Entry Date: 20110610. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Capillary Permeability
KW  - Ischemia -- Physiopathology
KW  - Movement Disorders -- Physiopathology
KW  - Spinal Cord -- Blood Supply
KW  - Animal Studies
KW  - Blood Circulation
KW  - Lower Extremity -- Physiopathology
KW  - Movement Disorders -- Etiology
KW  - Rabbits
KW  - Reperfusion
KW  - Serum Albumin
SP  - 367
EP  - 373
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 23
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Background and Purpose: Delayed deterioration of neurological function after central nervous system ischemia is a well-documented clinical problem. The purpose of our study was to elucidate the role of spinal cord blood flow and spinal cord-blood barrier integrity in the evolution of delayed neurological deterioration after transient spinal cord ischemia in rabbits.Methods: Anesthetized rabbits were subjected to lumbar spinal cord ischemia (25 minutes) and variable periods of reperfusion (30 minutes to 48 hours after ischemia). Regional spinal cord blood flow was monitored by carbon-14-labeled iodoantipyrine autoradiography; vascular permeability was assessed by quantitative microhistofluorescence of Evans blue-albumin in frozen sections of spinal cord. Hindlimb motor function was assessed by standard scoring system and tissue edema by wet/dry weight method.Results: Hindlimb motor function indicated complete paralysis during ischemia and partial gradual recovery upon reperfusion (up to 8 hours), followed by progressive deterioration to severe deficits over 48 hours. Severe vascular permeability disruption was noticed early (30 minutes) after reperfusion, but almost complete recovery reestablished at 8 hours was followed by a secondary progressive increase in vascular permeability. Blood flow was reduced by 20-30% (p less than 0.01) 4 hours after ischemia in the gray matter, but hyperemia (200-300%, p less than 0.01) was observed 12-24 hours after ischemia. Spinal cord water content increased by 5.7% (p less than 0.05) 24 hours after ischemia.Conclusions: This study demonstrates that delayed neurological and motor deterioration after spinal cord ischemia is associated with severe progressive breakdown of spinal cord-blood barrier integrity that develops late (hours) after the injury. Our data suggest that no ischemic insult in early or late reperfusion is associated with delayed motor deterioration.
SN  - 0039-2499
AD  - National Institutes of Health, Bethesda, Md.
U2  - PMID: 1542898.
DO  - 10.1161/01.STR.23.3.367
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - D. M. Fracaszy, Maureen
AU  - S. Boinski, Maureen
AU  - J. Whipple, Maureen
T1  - Behavioral Sampling in the Field: Comparison of Individual and Group Sampling Methods.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1992/04//
VL  - 26
IS  - 4
M3  - Article
SP  - 259
EP  - 275
SN  - 02752565
AB  - Sampling decisions affect the efficiency and reliability of data collection, and the appropriateness of the data for analyses of group and individual behavior. We evaluate the correspondence between interval sampling of individual behavior at high temporal density (focal interval sampling) with interval sampling of group behavior at lower density (group scan sampling) in two field studies with neotropical primates, capuchins and squirrel monkeys. The two methods provided consistent estimates of population means and variance for activity profiles, foraging activities, and height above ground. The correspondence between mean values with the two methods was greater when group sampling included individual identities than when a nominal scoring scheme was used. A group scan method without identification of individuals) can be used alone when information is needed within a brief time, such as initial description of activity budgets of a population. Although individual identities take time to learn, data sets in which the individual is the unit of analysis provide several other kinds of analytical possibilities. We recommend use of a mixed sampling regime containing both of these elements (focal and group sampling) as a good way to minimize the time costs of data collection and as a means to evaluate reliability of data collection by a solo observer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PRIMATE behavior
KW  - SQUIRREL monkeys
KW  - CAPUCHIN monkeys
KW  - FORAGING behavior (Animals)
KW  - ANIMAL behavior
KW  - CEBIDAE
KW  - behavioral observation
KW  - focal sampling
KW  - scan sampling.
N1  - Accession Number: 12323399; D. M. Fracaszy, Maureen 1 S. Boinski, Maureen 2 J. Whipple, Maureen 3; Affiliation:  1: Department of Psychology, University of Georgia, Athens.  2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolsville, Maryland.  3: Psychology Department, Washington State University, Pullman.; Source Info: 1992, Vol. 26 Issue 4, p259; Subject Term: PRIMATE behavior; Subject Term: SQUIRREL monkeys; Subject Term: CAPUCHIN monkeys; Subject Term: FORAGING behavior (Animals); Subject Term: ANIMAL behavior; Subject Term: CEBIDAE; Author-Supplied Keyword: behavioral observation; Author-Supplied Keyword: focal sampling; Author-Supplied Keyword: scan sampling.; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mukaida, N.
AU  - Gussella, G. L.
AU  - Kasahara, T.
AU  - Ko, Y.
AU  - Zachariae, C. O. C.
AU  - Kawai, T.
AU  - Matsushima, K.
T1  - Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line.
JO  - Immunology
JF  - Immunology
Y1  - 1992/04//
VL  - 75
IS  - 4
M3  - Article
SP  - 674
EP  - 679
PB  - Wiley-Blackwell
SN  - 00192805
AB  - In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8. Over a wide dose range, dexamethasone inhibited IL-8 production induced by IL-1α stimulation. Northern blotting analysis showed that dexamethasone also inhibited the IL-8 mRNA accumulation in a similar dose-related manner. Nuclear run-off assay revealed that dexamethasone decreased the transcription of the IL-8 gene and the degree of inhibition of transcription correlated well with the inhibition of IL-8 production, suggesting that the action of glucocorticoids is mainly at the transcriptional level. Furthermore, transfection with chloramphenicol acetyl transferase (CAT) expression vectors inserted with the 5′-deleted IL-8 gene demonstrated that the 5′-flanking region which contains the glucocorticoid response element (GRE) was mainly involved in the dexamethasone-induced repression of the IL-8 gene. These data suggest that the inhibition of the IL-8 gene transcription by glucocorticoids occurs through the interaction of the glucocorticoid receptor complex with GRE in the 5′-flanking region of the IL-8 gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLUCOCORTICOIDS
KW  - ANTI-inflammatory agents
KW  - INTERLEUKIN-8
KW  - INTERLEUKINS
KW  - FIBROMAS
KW  - MESSENGER RNA
N1  - Accession Number: 13491732; Mukaida, N. 1 Gussella, G. L. 2 Kasahara, T. 3 Ko, Y. 1 Zachariae, C. O. C. 4 Kawai, T. 1 Matsushima, K. 5; Affiliation:  1: Department of Clinical Pathology, Jichi Medical School, Minami-kawachi-machi, Japan  2: Program Resources, Inc/Dyn-Corp, Division of Cancer Treatment, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland, USA  3: Department of Medical Biology and Parasitology, Jichi Medical School, Minami-kawachi-machi, Japan  4: Biological Response Modifier Program, Division of Cancer Treatment, National Cancer Institute, Frederick Cancer Reseach and Development Center, Frederick, Maryland, USA  5: Department of Pharmacology, Cancer Research Institute, Kanazawa University, Takara-machi, Japan; Source Info: Apr92, Vol. 75 Issue 4, p674; Subject Term: GLUCOCORTICOIDS; Subject Term: ANTI-inflammatory agents; Subject Term: INTERLEUKIN-8; Subject Term: INTERLEUKINS; Subject Term: FIBROMAS; Subject Term: MESSENGER RNA; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Spitzer, Robert L.
AU  - Devlin, Michael
AU  - Walsh, B. Timothy
AU  - Hasin, Deborah
AU  - Wing, Rena
AU  - Marcus, Marsha
AU  - Stunkard, Albert
AU  - Wadden, Thomas
AU  - Yanovski, Susan
AU  - Agras, Stewart
AU  - Mitchell, James
AU  - Nonas, Cathy
T1  - Binge Eating Disorder: A Multisite Field Trial of the Diagnostic Criteria.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1992/04//
VL  - 11
IS  - 3
M3  - Article
SP  - 191
EP  - 203
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Diagnostic criteria have been developed for a new eating disorder, binge eating disorder (BED), to describe the many individuals who have problems with recurrent binge eating bur do not engage in the characteristic compensatory behaviors of bulimia nervosa, vomiting, or use of laxatives. The results of a multisite field trial involving 1,984 subjects indicate that the disorder is common (30.1%) among subjects attending hospital-affiliated weight control programs, but is relatively rare in the community (2.0%). The disorder is more common in females than in males and is associated with severity of obesity and a history of marked weight fluctuations. Based on these results, the DSM-IV Work Group on Eating Disorders has recommended that the disorder be considered for inclusion in DSM-IV, either as an official category or in an appendix of categories requiring further study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EATING disorders
KW  - APPETITE disorders
KW  - COMPULSIVE eating
KW  - ANOREXIA nervosa
KW  - BULIMIA
KW  - OBESITY
KW  - BODY weight
KW  - NUTRITION disorders
KW  - MENTAL health
KW  - NUTRITION
N1  - Accession Number: 11935265; Spitzer, Robert L. 1 Devlin, Michael 2 Walsh, B. Timothy 3 Hasin, Deborah 4 Wing, Rena 5 Marcus, Marsha 6 Stunkard, Albert 7 Wadden, Thomas 8 Yanovski, Susan 9 Agras, Stewart 10 Mitchell, James 11 Nonas, Cathy 12; Affiliation:  1: Professor of Psychology, Department of Psychiatry, Columbia University  2: Assistant Clinical Professor of Psychiatry, Department of Psychiatry, Columbia University  3: Professor of Clinical Psychiatry, Department of Psychiatry, Columbia University  4: Assistant Professor of Psychiatry and Public Health, Columbia University  5: Asociate Professor of Psychiatry, Psychology, and Epidemiology, University of Pittsburgh School of Medicine  6: Assistant Professor of Psychiatry and Psychology, University of Pittsburgh School of Medicine  7: Professor of Psychiatry, University of Pennsylvania  8: Associate Professor of Psychology, Psychiatry University of Pennsylvania  9: Research Associate, Clinical Neuroendocrinology Branch, National Institute of Mental Health  10: Professor of Psychiatry, Stanford University School of Medicine  11: Professor of Psychiatry, Department of Psychiatry, University of Minnesota  12: Director of program Development, United Weight Control Corporation, NYC; Source Info: Apr1992, Vol. 11 Issue 3, p191; Subject Term: EATING disorders; Subject Term: APPETITE disorders; Subject Term: COMPULSIVE eating; Subject Term: ANOREXIA nervosa; Subject Term: BULIMIA; Subject Term: OBESITY; Subject Term: BODY weight; Subject Term: NUTRITION disorders; Subject Term: MENTAL health; Subject Term: NUTRITION; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lisby, Gorm
AU  - Reitz Jr., Marvin S.
AU  - Vejlsgaard, Gunhild L.
T1  - No Detection of HTLV-I DNA in Punch Skin Biopsies from Patients with Cutaneous T-Cell Lymphoma by the Polymerase Chain Reaction.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/04//
VL  - 98
IS  - 4
M3  - Article
SP  - 417
EP  - 420
SN  - 0022202X
AB  - In this study we have tried to take advantage of the high genetic homology between conserved regions of human T-cell lymphotropic virus (HTLV) types I and II, hoping that a possible retrovirus in patients with cutaneous T-cell lymphoma (CTCL) would have regions with homology to types I/II. DNA was extracted from punch skin biopsies from 21 patients and subjected to the polymerase chain reaction (PCR), using primer sets designed to match conserved regions in the HTLV-I/II genome. The PCR products were subjected to agarose gel electrophoresis with subsequent Southern blotting and hybridization to an HTLV-I probe. No bands of exogenous origin were seen on the agarose gel or by hybridization. If a retrovirus is present in the skin in CTCL patients, it is either not related to HTLV-I/II, present at a copy number below the PCR detection limit, or has been cleared from the skin before the clinical symptoms appear. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOMOLOGY (Biology)
KW  - GENETICS
KW  - T cells
KW  - RETROVIRUSES
KW  - LYMPHOMAS
KW  - IMMUNOBLOTTING
N1  - Accession Number: 12499842; Lisby, Gorm 1 Reitz Jr., Marvin S. 2 Vejlsgaard, Gunhild L. 3; Affiliation:  1: Department of Clinical Microbiology, Herlev Hospital, Copenhagen, Denmark  2: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: Department of Dermatology, Rigshospitalet, Copenhagen, Denmark; Source Info: Apr92, Vol. 98 Issue 4, p417; Subject Term: HOMOLOGY (Biology); Subject Term: GENETICS; Subject Term: T cells; Subject Term: RETROVIRUSES; Subject Term: LYMPHOMAS; Subject Term: IMMUNOBLOTTING; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12499842
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Miller, Barry A.
AU  - Blair, Aaron
T1  - Cancer Risks among Artists.
JO  - Leonardo
JF  - Leonardo
Y1  - 1992/04//
VL  - 25
IS  - 2
M3  - Article
SP  - 169
EP  - 173
SN  - 0024094X
AB  - Cancer risks among professional artists were evaluated by these authors in two study populations. In a mortality study based on artists obituaries, excess deaths occurred from bladder cancer and leukemia among white male painters, breast cancer among white female painters, and prostate cancer among white male sculptors. Data from a separate investigation, a nationwide interview study of bladder cancer patients, supports the association found in the mortality study of bladder cancer with employment as a painter. Information was not available for the identification of specific substances that are causing the observed cancer risks, however, efforts should focus on limiting exposure to materials that are potentially hazardous. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leonardo is the property of MIT Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Painters
KW  - Cancer -- Risk factors
KW  - Artists -- Diseases
KW  - Mortality
KW  - Cancer patients
KW  - Bladder cancer
N1  - Accession Number: 26214227; Miller, Barry A. 1; Blair, Aaron 2; Affiliations: 1 : Surveillance Program, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, U.S.A.; 2 : Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, U.S.A.;  Source Info: 1992, Vol. 25 Issue 2, p169; Thesaurus Term: Painters; Subject Term: Cancer -- Risk factors; Subject Term: Artists -- Diseases; Subject Term: Mortality; Subject Term: Cancer patients; Subject Term: Bladder cancer; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - vth
ER  - 

TY  - JOUR
ID  - 104741942
T1  - Systemic morphine administration attenuates the perceived intensity of noxious heat in the monkey.
AU  - Thomas, D A
AU  - Oliveras, J L
AU  - Maixner, W
AU  - Dubner, R
Y1  - 1992/04//1992 Apr
N1  - Accession Number: 104741942. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Discrimination
KW  - Heat
KW  - Morphine -- Pharmacodynamics
KW  - Sensation -- Drug Effects
KW  - Animals
KW  - Cold
KW  - Dose-Response Relationship, Drug
KW  - Primates
KW  - Male
KW  - Naloxone -- Pharmacodynamics
KW  - Pain
KW  - Physical Stimulation
KW  - Perception
SP  - 129
EP  - 135
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 49
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1594274.
DO  - 10.1016/0304-3959(92)90199-L
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1992-42246-001
AN  - 1992-42246-001
AU  - Cline, E. J.
AU  - Terry, P.
AU  - Carroll, F. Ivy
AU  - Kuhar, M. J.
AU  - Katz, J. L
T1  - Stimulus generalization from cocaine to analogs with high in vitro affinity for dopamine uptake sites.
JF  - Behavioural Pharmacology
JO  - Behavioural Pharmacology
JA  - Behav Pharmacol
Y1  - 1992/04//
VL  - 3
IS  - 2
SP  - 113
EP  - 116
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0955-8810
SN  - 1473-5849
N1  - Accession Number: 1992-42246-001. PMID: 11224107 Partial author list: First Author & Affiliation: Cline, E. J.; National Institute on Drug Abuse Addiction Research Ctr, Molecular Pharmacology Lab, Baltimore, MD, US. Release Date: 19921201. Correction Date: 20130225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cocaine; Dopamine; Drug Discrimination; Response Generalization. Minor Descriptor: Animal Models; Drug Abuse; Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Page Count: 4. Issue Publication Date: Apr, 1992. 
AB  - Tested phenyltropane derivatives of cocaine for their ability to substitute for cocaine in 5 male rats trained to discriminate cocaine from saline. Results indicate that these compounds are 6–23 times more potent than cocaine in producing cocaine-appropriate responding. Results indicate the importance of dopamine uptake inhibition for the behavioral effects of cocaine, and suggest the utility of these compounds in understanding cocaine abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cocaine analogs with high affinity for dopamine uptake sites
KW  - stimulus generalization
KW  - male rats trained to discriminate cocaine from saline
KW  - animal model of enhanced drug potency & behavioral effects
KW  - 1992
KW  - Cocaine
KW  - Dopamine
KW  - Drug Discrimination
KW  - Response Generalization
KW  - Animal Models
KW  - Drug Abuse
KW  - Rats
KW  - 1992
DO  - 10.1097/00008877-199204000-00002
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Slattery, Martha L.
AU  - McDonald, Arline
AU  - Bud, Diane E.
AU  - Caan, Bette J.
AU  - Hilner, Joan E.
AU  - Jacobs Jr, David R.
AU  - Kiang Liu
T1  - Associations of body fat and its distribution with dietary intake, physical activity, alcohol, and smoking in blacks and whites.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/05//
VL  - 55
IS  - 5
M3  - Article
SP  - 943
EP  - 949
SN  - 00029165
AB  - Cross-sectional associations between body fat and its distribution and environmental factors influencing energy balance were examined in 5115 young adults. Protein was directly associated with body mass index (BMI) in all race and sex groups (P < 0.01) after age, education, cigarette-smoking status, alcohol intake, and physical activity were adjusted for. Carbohydrate intake was inversely associated with BMI in males (P = 0.02). Total physical activity was inversely associated with BMI in white women and with skinfold-thickness measures (P < 0.01) in all groups. Waist-to-hip-circumference ratio (WHCR) was positively associated with total kilojoules (kilocalories) in women, inversely associated with percent of kilojoules (kilocalories) from carbohydrates in whites, grams of crude fiber/4184 kJ (1000 kcal) (except in black men), and physical activity (except in white women). WHCR was directly associated with cigarette smoking except in black men, and with total alcohol intake in men. Beer was consistently associated with WHCR in all race and sex groups. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Body composition
KW  - Bioenergetics
KW  - Physical activity -- Physiological aspects
KW  - Tobacco -- Physiological effect
KW  - Proteins in human nutrition
KW  - Body mass index
KW  - Alcohol
KW  - body fat
KW  - cigarette smoking
KW  - dietary intake
KW  - physical activity
N1  - Accession Number: 94402945; Slattery, Martha L. 1; McDonald, Arline 2; Bud, Diane E. 3; Caan, Bette J. 4; Hilner, Joan E. 5; Jacobs Jr, David R. 6; Kiang Liu 7; Affiliations: 1: Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City; 2: Department of Nutrition and Medical Dietetics, University of Illinois, Chicago; 3: National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, MD; 4: Division of Research, Kaiser Permanente Medical Care Program (Northern California Region), Oakland, CA; 5: CARDIA Coordinating Center, University of Alabama at Birmingham; 6: Division of Epidemiology, University of Minnesota, Minneapolis; 7: Department of Community Health and Preventive Medicine, Northwestern University Medical School, Chicago; Issue Info: May1992, Vol. 55 Issue 5, p943; Thesaurus Term: Body composition; Thesaurus Term: Bioenergetics; Subject Term: Physical activity -- Physiological aspects; Subject Term: Tobacco -- Physiological effect; Subject Term: Proteins in human nutrition; Subject Term: Body mass index; Author-Supplied Keyword: Alcohol; Author-Supplied Keyword: body fat; Author-Supplied Keyword: cigarette smoking; Author-Supplied Keyword: dietary intake; Author-Supplied Keyword: physical activity; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104742570
T1  - Gender-linked differences in everyday memory performance.
AU  - Herrmann, D J
AU  - Crawford, M
AU  - Holdsworth, M
Y1  - 1992/05//
N1  - Accession Number: 104742570. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373124. 
KW  - Gender Identity
KW  - Memory
KW  - Stereotyping
KW  - Adolescence
KW  - Adult
KW  - Female
KW  - Male
SP  - 221
EP  - 231
JO  - British Journal of Psychology
JF  - British Journal of Psychology
JA  - BR J PSYCHOL
VL  - 83
IS  - 2
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Recent research has demonstrated that people hold beliefs about how well others perform everyday memory tasks according to another's sex. For example, meta-memory ratings indicate that other men and other women are believed to differ in their success at performing certain memory tasks (Crawford, Herrmann, Holdsworth, Randall & Robbins, 1989). In the present study, two experiments investigated whether gender stereotypes concerning everyday memory have any validity. Experiment 1 presented female and male subjects with two tasks that the aforementioned meta-memory ratings had shown are implicitly gender marked: learning a shopping list (a sterotypically feminine task) and learning directions to go to a particular place (a stereotypically masculine task). The results were consistent with the gender stereotypes, i.e. women recalled more of the shopping list than men whereas men recalled more of the directions than women. The second experiment investigated whether memory performance would be influenced by mere changes in the label of materials in memory tasks to be biased toward male or female gender background: labelling a shopping list as pertaining to 'groceries' or to 'hardware store'; and a set of directions to 'make a shirt' or to 'make a workbench'. The results also indicated that memory performance varied in ways consistent with gender stereotypes.
SN  - 0007-1269
AD  - Laboratory of Socio-environmental Studies, National Institute of Mental Health, Washington, DC.
U2  - PMID: 1611409.
DO  - 10.1111/j.2044-8295.1992.tb02436.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lingen, Arthur
AU  - Huijgens, Peter
AU  - Visser, Frans
AU  - Ossenkoppele, Gert
AU  - Hoekstra, Otto
AU  - Martens, Harry
AU  - Huitink, Hans
AU  - Herscheid, Koos
AU  - Greens, Michael
AU  - Teule, Gerrit
T1  - Performance characteristics of a 511-keV collimator for imaging positron emitters with a standard gamma-camera.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1992/05//
VL  - 19
IS  - 5
M3  - Article
SP  - 315
EP  - 321
SN  - 03406997
N1  - Accession Number: 71144703; Lingen, Arthur 1 Huijgens, Peter 2 Visser, Frans 3 Ossenkoppele, Gert 2 Hoekstra, Otto 1 Martens, Harry 4 Huitink, Hans 3 Herscheid, Koos 5 Greens, Michael 6 Teule, Gerrit 1; Affiliation:  1: Department of Nuclear Medicine, Free University Hospital, De Boelelaan 1117 NL-1081 HV Amsterdam The Netherlands  2: Department of Haematology, Free University Hospital, De Boelelaan 1117 NL-1081 HV Amsterdam The Netherlands  3: Department of Cardiology, Free University Hospital, De Boelelaan 1117 NL-1081 HV Amsterdam The Netherlands  4: Department of Pharmacology, Free University Hospital, De Boelelaan 1117 NL-1081 HV Amsterdam The Netherlands  5: Radionuclide Center, Free University, Amsterdam The Netherlands  6: National Institutes of Health, Bethesda USA; Source Info: May1992, Vol. 19 Issue 5, p315; Number of Pages: 7p; Document Type: Article
L3  - 10.1007/BF00177052
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1992-43651-001
AN  - 1992-43651-001
AU  - Linet, Martha S.
AU  - Ziegler, Dewey K.
AU  - Stewart, Walter F.
T1  - Headaches preceded by visual aura among adolescents and young adults: A population-based survey.
JF  - Archives of Neurology
JO  - Archives of Neurology
JA  - Arch Neurol
Y1  - 1992/05//
VL  - 49
IS  - 5
SP  - 512
EP  - 516
CY  - US
PB  - American Medical Association
SN  - 0003-9942
SN  - 1538-3687
N1  - Accession Number: 1992-43651-001. PMID: 1580814 Other Journal Title: A.M.A. Archives of Neurology; JAMA Neurology. Partial author list: First Author & Affiliation: Linet, Martha S.; NIH National Cancer Institute Div of Cancer Etiology, Epidemiology & Biostatistics Program Analytic Studies Section, Rockville, MD, US. Release Date: 19921201. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aura; Headache; Symptoms. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 5. Issue Publication Date: May, 1992. 
AB  - Investigated headache attacks preceded by visual aura among 8,920 Ss (aged 12–29 yrs) with at least 1 headache in the preceding year. 1,783 males and 3,029 females had experienced 1 or more headaches during the week prior to the interview, of whom 447 Ss (8.4% of male and 9.8% of female Ss) experienced visual aura symptoms. Visual aura headache (VAH) attack rate decreased with increasing age among males, but not among females. Regardless of gender, VAH attacks with tension symptoms were more likely to be accompanied by nausea and vomiting than were attacks without these symptoms. Among females, the 1-wk risk for VAHs without tension symptoms decreased with age, whereas the attack rate for VAH with these symptoms increased with age; there was no clear pattern for males. For Ss with VAHs, the aura interval was similar among age groups but differed with gender. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - symptoms
KW  - 12–29 yr olds with headache attacks with preceding visual aura
KW  - 1992
KW  - Aura
KW  - Headache
KW  - Symptoms
KW  - 1992
DO  - 10.1001/archneur.1992.00530290100018
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Lenfant, Claude
T1  - Preface.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1992/05/02/May1992 Supplement 1
VL  - 22
M3  - Article
SP  - 1
EP  - 1
PB  - Wiley-Blackwell
SN  - 09547894
AB  - The article focuses on asthma, a chronic lung disease that affects people of all ages. Data from many countries suggest that both asthma morbidity and mortality are increasing, although the reasons for this are not clear. Medical communities in several countries have responded to this concern by convening panels of asthma specialists to develop guidelines on asthma detection and treatment and to disseminate the panel reports through their respective societies and medical journals. The National Heart Lung and Blood Institute of the United States Public Health Service thought it would be important to the international community of asthma patients and health care providers to discuss differences and similarities among the various documents.
KW  - ASTHMA -- Treatment
KW  - MEDICAL journalism
KW  - LUNG diseases
KW  - MEDICAL care
KW  - UNITED States
KW  - UNITED States. Public Health Service
N1  - Accession Number: 16280531; Lenfant, Claude 1; Affiliation:  1: National Heart, Lung, And Blood Institute, National Institutes of Health, United States.; Source Info: May1992 Supplement 1, Vol. 22, Preceding p1; Subject Term: ASTHMA -- Treatment; Subject Term: MEDICAL journalism; Subject Term: LUNG diseases; Subject Term: MEDICAL care; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nakata, Hiroyasu
T1  - Biochemical and immunological characterization of A1 adenosine receptors purified from human brain membranes.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1992/05/15/
VL  - 206
IS  - 1
M3  - Article
SP  - 171
EP  - 177
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The A1 adenosine receptor was purified approximately 13000-fold to apparent homogeneity from human cerebral cortex membranes using a novel affinity-chromatography system developed for the purification of rat brain and rat testis A1 adenosine receptors [Nakata, H. (1989) J. Biol. Chem. 264, 16545-16551; Nakata, H. (1990) J. Biol. Chem. 265, 671-677]. The purified human brain receptor showed the ligand-binding specificity expected of the A1 adenosine receptor. The Bmax and Kd for the purified receptor with a specific A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-[3H]dipropylxanthine, were approximately 16 nmol/mg protein and 2 nM, respectively. SDS/PAGE of the purified receptor preparation showed one broad protein band of molecular mass of approximately 35 kDa, which is very similar to that of purified A1 adenosine receptor from rat brain membranes. Endoglycosidase F treatment of the purified receptor reduced the molecular mass to approximately 30 kDa, suggesting that the human brain A1 adenosine receptors by peptide mapping after the proteolytic digestion showed minor differences these receptors. Immunological comparisons of the human brain A1 adenosine receptor with rat brain A1 adenosine receptor using polyclonal antibodies against the purified rat brain A1 adenosine receptor showed that the antibodies react preferentially with the rat brain receptor and weakly with human brain receptor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADENOSINE
KW  - BIOCHEMISTRY
KW  - IMMUNOLOGY
KW  - CEREBRAL cortex
KW  - LIGAND binding (Biochemistry)
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 13441893; Nakata, Hiroyasu 1; Affiliation:  1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, USA and Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan; Source Info: 5/15/92, Vol. 206 Issue 1, p171; Subject Term: ADENOSINE; Subject Term: BIOCHEMISTRY; Subject Term: IMMUNOLOGY; Subject Term: CEREBRAL cortex; Subject Term: LIGAND binding (Biochemistry); Subject Term: IMMUNOGLOBULINS; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Maiman, Lois A.
AU  - Hildreth, Nancy G.
AU  - Cox, Christopher
AU  - Greenland, Philip
T1  - Improving Referral Compliance after Public Cholesterol Screening.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/06//
VL  - 82
IS  - 6
M3  - Article
SP  - 804
EP  - 809
PB  - American Public Health Association
SN  - 00900036
AB  - Background. Noncompliance with referral to a physician for retesting and diagnosis is a concern in public cholesterol screening. Methods. Participants (n = 2109) were referred by a health professional or lay communicator and randomly assigned to a coupon offer, referral reminder letter, or control group. A questionnaire was completed at screening, and a telephone interview was conducted 5 months later. Results. Physician visit rates showed no professional or lay differences. For "no history" subjects, the behavioral interventions were effective compared with controls (coupon = 60.7% and reminder = 57.7% vs control = 46.1%). With professional counseling, only the coupon was effective; for lay counseling, both coupon and reminder yielded higher visit rates. Adjusted for sociodemographics, heart disease risk factors, and health perceptions, the intervention effects remained (professional-coupon offer: odds ratio [OR] = 1.94, 95% confidence interval [CI] = 1.21, 3.09%, professional-reminder letter: OR = 1.04, 95% CI = 0.67, 1.63; lay-coupon offer: OR = 2.52, 95% CI = 1.52, 4.18; and lay-reminder letter: ZOR = 3.10, 95% CI = 1.83, 5.22). Conclusions. For unaware participants, lay counselors and referral follow-up efforts tailored to specific cholesterol risk groups are indicated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHYSICIANS
KW  - CHOLESTEROL
KW  - MEDICAL screening
KW  - BEHAVIOR therapy
KW  - COUNSELORS
N1  - Accession Number: 9207200289; Maiman, Lois A. 1 Hildreth, Nancy G. Cox, Christopher Greenland, Philip 2; Affiliation:  1: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Md.  2: Department of Community Health and Preventive Medicine, Northwestern University Medical School, Chicago; Source Info: Jun92, Vol. 82 Issue 6, p804; Subject Term: PHYSICIANS; Subject Term: CHOLESTEROL; Subject Term: MEDICAL screening; Subject Term: BEHAVIOR therapy; Subject Term: COUNSELORS; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Ain, K. B.;
AU  - Pucino, F.;
AU  - Drass, J. A.;
AU  - Csako, G.;
AU  - Dorworth, T. E.;
AU  - \ET/;
T1  - Comparison of a restrictive and nonrestrictive levothyroxine formulary system
CT  - Comparison of a restrictive and nonrestrictive levothyroxine formulary system
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1992/06/01/
VL  - 49
IS  - Jun
SP  - P
EP  - R
AD  - Warren Grant Magnuson Clinical Center, Rm 1N-257, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
N1  - Accession Number: 29-06899; Language: English; Chemical Name: Levothyroxine--51-48-9; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice
N2  - The effect of formulary restrictions on levothyroxine dosage formulations was evaluated in this prospective, randomized trial. Fifty endocrinologists from the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Child Health and Human Development were randomly assigned to restricted (25, 50, 100, 125 and 150 mcg dosage formulations permitted) or nonrestricted (25, 50, 75, 100, 112, 125, 150, 175, 200, and 300 mcg dosage formulations permitted) levothyroxine prescribing groups through the medical information computer system (medications ordered via the computer system). Thyroid function tests (free and total thyroxine, total triiodothyronine, and second generation thyrotropin assays), prescribing patterns, patient compliance (by survey), frequency of thyroid function studies and clinic visits, vital signs, medication distribution accuracy, inventory cost and success in achieving therapeutic objectives were determined for all patients presc ibed levothyroxine by any of the participating endocrinologists. Data from 460 patients has been collected over a two-year study period and is being analyzed for significant differences between patients of restricted or nonrestricted physicians. Due to the frequency of levothyroxine prescribing, compliance problems from formulary restrictions, a narrow therapeutic index for achievement of therapeutic targets, significant cost to pharmacies and manufacturers, and the availability of sensitive outcome indicators, this study, to determine the effects of levothyroxine prescribing restrictions, is necessary. These results may assist Pharmacy and Therapeutic Committees in determining the potential benefits and disadvantages from restricting dosage formulations of other medications available in multiple dosage formulations.
KW  - Levothyroxine--dosage forms-;
KW  - ASHP meeting abstracts--levothyroxine formulary restrictions;
KW  - Formulary system--levothyroxine--formulations, control;
KW  - Dosage forms--levothyroxine--formulary control;
KW  - Pharmacy, institutional, hospital--formularies--levothyroxine formulary control;
KW  - Practice Interest Areas--General Clinical Practice--meeting presentations;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Crawford, K.;
AU  - Scott, D.;
AU  - Yarboro, C. H.;
AU  - Sebring, N. G.;
AU  - Pucino, F.;
AU  - \ET/;
T1  - Efficacy of lovastatin in the treatment of hyperlipidemia of systemic lupus erythematosus
CT  - Efficacy of lovastatin in the treatment of hyperlipidemia of systemic lupus erythematosus
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1992/06/01/
VL  - 49
IS  - Jun
SP  - CR
EP  - -2
AD  - Warren Grant Magnuson Clinical Center, Rm 1N-257, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
N1  - Accession Number: 29-07021; Language: English; Chemical Name: Lovastatin--75330-75-5; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Drug Evaluations
N2  - The efficacy of lovastatin in systemic lupus erythematosus (SLE) associated hyperlipidemia was determined in this double-blinded, randomized, crossover trial. Eight SLE patients were recruited for a 20-week study period. Two baseline lipid panels (total, LDL, HDL, and VLDL cholesterols, triglycerides, and apolipoproteins A-I, A-II, B and LP(a)) were determined over a two-week period. Following six weeks on an American Heart Association step two cholesterol-lowering diet, patients were randomly assigned to control (identical placebo tablets and diet) or intervention (lovastatin 40 mg daily and diet) groups for a six-week treatment period, and were subsequently crossed over to the alternate therapy for an additional six weeks. Lipid panels were repeated following diet, control and intervention phases and compared statistically. Lipid analysis from diet and placebo phases were not statistically different than baseline determinations. Lovastatin was significantly different than baseline, diet, and placebo for lowering total (mean \-/27.4 vs baseline) and LDL (\-/37.3 vs baseline) cholesterols, and statistically different than baseline for increasing HDL cholesterol (18.4) and decreasing triglycerides (\-/27) and VLDL cholesterol (\-/27). Apolipoprotein A-I concentration increased (28.7) and LP(a) decreased (\-/23) following lovastatin therapy, but were not significantly different from baseline. Side effects were mild and did not differ between control and intervention groups. Lovastatin appears to be a safe and effective treatment for SLE associated hyperlipidemia. Further analysis is required to determine the effects of lovastatin on apolipoproteins, and to assess relative efficacy between patients with or without proteinuria.
KW  - Lovastatin--hyperlipidemia-;
KW  - ASHP meeting abstracts--lovastatin, lupus erythematosus;
KW  - Lupus erythematosus--lovastatin--systemic, hyperlipidemia therapy;
KW  - Hyperlipidemia--lovastatin--therapy, systemic lupus erythematosus;
KW  - Practice Interest Areas--Cardiovascular/Critical Care--meeting presentations;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Minor, J. R.;
T1  - Preventing accidental exposure to HIV
CT  - Preventing accidental exposure to HIV
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1992/06/01/
VL  - 49
IS  - Jun
SP  - PI
EP  - 58
AD  - National Institutes of Health Clinical Center Pharmacy Department, Building 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 29-07082; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Environmental Toxicity; Institutional Pharmacy Practice
N2  - This presentation will review risks of acquiring HIV infection in the health care setting, and recommend isolation precautions, safe-handling techniques, and job practices and procedures designed to prevent adverse occupational exposures.
KW  - ASHP meeting abstracts--HIV infection exposure, hospital personnel;
KW  - Personnel--hospitals--HIV infection exposure;
KW  - HIV infections--toxicity, environmental--hospital personnel;
KW  - Toxicity, environmental--HIV infections--exposure, hospital personnel;
KW  - Hospitals--personnel--HIV infection exposure, policies;
KW  - Administration--policies and procedures--hospital personnel, HIV infection exposure;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Costa Jr., Paul T.
AU  - McCrae, Robert R.
T1  - Multiple uses for longitudinal personality data.
JO  - European Journal of Personality
JF  - European Journal of Personality
Y1  - 1992/06//
VL  - 6
IS  - 2
M3  - Article
SP  - 85
EP  - 102
PB  - John Wiley & Sons, Inc.
SN  - 08902070
AB  - Most longitudinal studies are designed to serve fairly narrow purposes, such as the prediction of life outcomes from theoretically relevant antecedent variables, or the documentation of age-related changes in the level of personality or cognitive variables. However, the accumulation of data on a single group of people observed over a period of many years permits a variety of other types of analyses. Creative use of a longitudinal archive can amply justify the costs of maintaining the sample and should encourage investigators to initiate more longitudinal projects. Findings from the Baltimore Longitudinal Study of Aging are used to illustrate both traditional and alternative uses of personality data, including (a) development of nomological nets for the interpretation of personality measures, (b) evaluation of state effects in personality measurement., (c) validation of retrospective reports, and (d) heuristic exploratory analyses. Current knowledge on the stability of personality in adulthood, the correspondence of observer ratings and self-reports, and the comprehensiveness of the five-factor model can enhance the design of future longitudinal studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Personality is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LONGITUDINAL method
KW  - PERSONALITY -- Research
KW  - DEVELOPMENTAL psychology
KW  - PERSONALITY change
KW  - PERSONALITY -- Age factors
KW  - STABILITY (Mechanics)
N1  - Accession Number: 12110574; Costa Jr., Paul T. 1 McCrae, Robert R. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH, Baltimore, Maryland, USA; Source Info: Jun92, Vol. 6 Issue 2, p85; Subject Term: LONGITUDINAL method; Subject Term: PERSONALITY -- Research; Subject Term: DEVELOPMENTAL psychology; Subject Term: PERSONALITY change; Subject Term: PERSONALITY -- Age factors; Subject Term: STABILITY (Mechanics); Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104743776
T1  - Maternal recall of infant feeding events is accurate.
AU  - Launer, L J
AU  - Forman, M R
AU  - Hundt, G L
AU  - Sarov, B
AU  - Chang, D
AU  - Berendes, H W
AU  - Naggan, L
Y1  - 1992/06//
N1  - Accession Number: 104743776. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 7909766. 
KW  - Eating Behavior
KW  - Memory
KW  - Mothers -- Psychosocial Factors
KW  - Bottle Feeding
KW  - Breast Feeding
KW  - Child Development
KW  - Child, Preschool
KW  - Prospective Studies
KW  - Human
KW  - Infant
KW  - Infant Food
KW  - Infant, Newborn
KW  - Retrospective Design
KW  - Sensitivity and Specificity
SP  - 203
EP  - 206
JO  - Journal of Epidemiology & Community Health
JF  - Journal of Epidemiology & Community Health
JA  - J EPIDEMIOL COMMUNITY HEALTH
VL  - 46
IS  - 3
PB  - BMJ Publishing Group
AB  - Retrospective infant feeding data are important to the study of child and adult health patterns. The accuracy of maternal recall of past infant feeding events was examined and specifically the infant's age when breast feeding was stopped and formula feeding and solid foods were introduced. The sample consisted of Bedouin Arab women (n = 318) living in the Negev in Israel who were a part of a larger cohort participating in a prospective study of infant health and who were delivered of their infants between July 1 and December 15, 1981. Data from interviews conducted 12 and 18 months postpartum were compared to the standard data collected six months postpartum. As length of recall increased there was a small increase in the mean difference, and its standard deviation, between the standard and recalled age when breast feeding was stopped and formula feeding and solid foods were started. Recall on formula feeding was less accurate than recall on solid foods and breast feeding. In particular, among those 61% reporting formula use at the six month interview, 51% did not recall introducing formula when interviewed at 18 months. The odds ratio (95% CI) of stunting versus normal length for age for formula fed versus breast fed infants based on recall data (OR = 2.07; 95% CI 0.82-5.22) differed only slightly from those based on the standard data (OR = 2.21; 95% CI 0.77-6.37). The accuracy of a mother's recall varied with her child's nutritional status at the time of the interview, but not with other sociodemographic, infant, or interviewer characteristics. Retrospective infant feeding data based on maternal recall of events up to 18 months in the past can be used with confidence in epidemiological studies. However, data on formula feeding may not be as accurate as data on breast feeding and solid food feeding, and accuracy may decrease as length of recall increases.
SN  - 0143-005X
AD  - Division of Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1645071.
DO  - 10.1136/jech.46.3.203
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104743776&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - John, Oliver P.
T1  - An Introduction to the Five-Factor Model and its Applications.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1992/06//
VL  - 60
IS  - 2
M3  - Article
SP  - 175
EP  - 215
PB  - Wiley-Blackwell
SN  - 00223506
AB  - The five-factor model of personality is a hierarchical organization of personality traits in terms of five basic dimensions: Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience. Research using both natural language adjectives and theoretically based personality questionnaires supports the comprehensiveness of the model and its applicability across observers and cultures. This article summarizes the history of the model and its supporting evidence; discusses conceptions of the nature of the factors; and outlines an agenda for theorizing about the origins and operation of the factors. We argue that the model should prove useful both for individual assessment and for the elucidation of a number of topics of interest to personality psychologists. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - EXTRAVERSION
KW  - LANGUAGE & languages
KW  - PERSONALITY questionnaires
KW  - PERSONALITY & culture
KW  - LANGUAGE & culture
N1  - Accession Number: 9208170743; McCrae, Robert R. 1 John, Oliver P. 2; Affiliation:  1: National Institute on Aging, NIH  2: University of California, Berkeley; Source Info: Jun92, Vol. 60 Issue 2, p175; Subject Term: PERSONALITY; Subject Term: EXTRAVERSION; Subject Term: LANGUAGE & languages; Subject Term: PERSONALITY questionnaires; Subject Term: PERSONALITY & culture; Subject Term: LANGUAGE & culture; Number of Pages: 41p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
T1  - Editor's Introduction to Tupes and Christal.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1992/06//
VL  - 60
IS  - 2
M3  - Article
SP  - 217
EP  - 219
PB  - Wiley-Blackwell
SN  - 00223506
AB  - This article cites the importance of the E. C. Tupes and R. E. Christal's study Recurrent Personality Factors Based on Trait Ratings to future elaborations on the five-factor research model. The study is undoubtedly the pivotal work that summarized and crystallized previous research. The data analyzed are themselves central to the history of personality assessment. Statistically, Tupes and Christal's article is pivotal in another sense: It was one of the last major projects to employ factor analysis based on hand calculations, and one to employ the results of a computer analysis using varimax rotation. But perhaps the most impressive feature of Recurrent Personality Factors is its conceptual sophistication. This can be seen both in the author's ready acknowledgment of the limitations of the study and in their pragmatic emphasis on the value of robust and generalizable findings despite the limitation.
KW  - PERSONALITY
KW  - PERSONALITY assessment
KW  - FACTOR analysis
KW  - COMPUTER simulation
KW  - PERSONALITY tests
KW  - PSYCHODIAGNOSTICS
N1  - Accession Number: 9208170744; McCrae, Robert R. 1; Affiliation:  1: National Institute on Aging, NIH; Source Info: Jun92, Vol. 60 Issue 2, p217; Subject Term: PERSONALITY; Subject Term: PERSONALITY assessment; Subject Term: FACTOR analysis; Subject Term: COMPUTER simulation; Subject Term: PERSONALITY tests; Subject Term: PSYCHODIAGNOSTICS; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wilbur, W. John
T1  - Retrieval Testing by the Comparison of Statistically Independent Retrieval Methods.
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
Y1  - 1992/06//
VL  - 43
IS  - 5
M3  - Article
SP  - 356
EP  - 370
SN  - 00028231
AB  - A procedure for retrieval testing is developed which is based on the comparison of statistically independent methods of retrieval applied to the same database. This is, in essence, a form of relative retrieval testing in which, due to the independence assumption, the conclusions drawn may be taken as absolute. The methodology is illustrated on a large database of MEDLINE records where documents are themselves used as queries. Test results in this setting indicate that, among the several methods tested, a form of cosine coefficient retrieval will give the best performance for the purpose of clustering documents or producing nearest neighbors of documents. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INFORMATION retrieval
KW  - DATABASES
KW  - DOCUMENTATION
KW  - METHODOLOGY
KW  - MEDLINE
N1  - Accession Number: 16801538; Wilbur, W. John 1; Affiliations: 1: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health? 8600 Rocky/he Pike, Bethesda, MD 20894; Issue Info: Jun1992, Vol. 43 Issue 5, p356; Thesaurus Term: INFORMATION retrieval; Thesaurus Term: DATABASES; Thesaurus Term: DOCUMENTATION; Subject Term: METHODOLOGY; Subject Term: MEDLINE; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Ellenberg, Susan S.
AU  - Finkelstein, Dianne M.
AU  - Schoenfeld, David A.
T1  - Statistical Issues Arising in AIDS Clinical Trials.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1992/06//
VL  - 87
IS  - 418
M3  - Article
SP  - 562
EP  - 569
SN  - 01621459
AB  - In the 11 years since AIDS became a defined disease, programs for the development and evaluation of new drugs for this disease have grown rapidly. Although the fundamental principles that drive the design, conduct, and analysis of clinical trials are as applicable to AIDS as to other diseases, there is no question that we have been confronted with unusually difficult challenges in studying therapeutic approaches for this disease. These include the multiple treatment needs of individual patients, identification of appropriate endpoints, rapidly changing "natural history," and the need for interaction with an informed and vocal patient community that continues to express dissatisfaction with the pace of research. In this context, statisticians have taken a leadership role in identifying and addressing important methodological issues in the evaluation of AIDS drugs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - STATISTICS
KW  - AIDS (Disease)
KW  - CLINICAL trials
KW  - MEDICAL experimentation on humans
KW  - MEDICAL research
KW  - CLINICAL medicine
KW  - Acquired immune deficiency syndrome
KW  - Clinical trials
KW  - Human immunodeficiency virus
N1  - Accession Number: 9705253029; Ellenberg, Susan S. 1; Finkelstein, Dianne M. 2; Schoenfeld, David A. 2; Affiliations: 1: Chief, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6003 Executive Blvd., Bethesda, MD 20892.; 2: Associate Professors, Biostatistics, Harvard University School of Public Health and School of Medicine, Boston, MA 02115.; Issue Info: Jun92, Vol. 87 Issue 418, p562; Thesaurus Term: RESEARCH; Thesaurus Term: STATISTICS; Subject Term: AIDS (Disease); Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; Subject Term: MEDICAL research; Subject Term: CLINICAL medicine; Author-Supplied Keyword: Acquired immune deficiency syndrome; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Human immunodeficiency virus; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article; Full Text Word Count: 8148
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 2010-15425-009
AN  - 2010-15425-009
AU  - Muehrer, Peter
AU  - Koretz, Doreen S.
T1  - Issues in preventive intervention research.
JF  - Current Directions in Psychological Science
JO  - Current Directions in Psychological Science
JA  - Curr Dir Psychol Sci
Y1  - 1992/06//
VL  - 1
IS  - 3
SP  - 109
EP  - 112
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0963-7214
SN  - 1467-8721
AD  - Muehrer, Peter, Prevention Research Branch, Division of Clinical Research, National Institute of Mental Health, 10-85 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2010-15425-009. Partial author list: First Author & Affiliation: Muehrer, Peter; Youth Mental Health Program, Prevention Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Sage Publications; Wiley-Blackwell Publishing Ltd. Release Date: 20100802. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Promotion; Intervention; Mental Disorders; Mental Health; Prevention. Minor Descriptor: Experimentation; Methodology. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Page Count: 4. Issue Publication Date: Jun, 1992. Copyright Statement: American Psychological Association. 1992. 
AB  - Mental health researchers and service providers are increasingly interested in the prevention of mental disorders and related serious problems. Prevention offers the potential for avoiding widespread human suffering, as well as saving costs associated with treatment and lost productivity. Furthermore, preventive intervention trials provide a strong test of causal theory: The successful modification of processes and mechanisms hypothesized to cause adverse outcomes, and subsequent avoidance of these outcomes, helps investigators to discern a causal relationship. Consequently, much activity aimed at preventing a wide variety of psychological dysfunctions has occurred in recent decades. Although not enough well-designed research has been conducted to provide strong evidence for effectiveness, findings from several efforts illustrate the promise of prevention. These studies provide examples of benefits gained from preventive interventions. Prevention science aimed at mental disorders and the promotion of mental health continue to grow, as does the sophistication with which investigators seek to answer the complex questions raised by such research. The purpose of this article is to outline briefly critical components of sound prevention research that allow interventions to be confidently linked to changes in outcome. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental disorders
KW  - prevention research
KW  - prevention intervention
KW  - mental health promotion
KW  - methodology
KW  - 1992
KW  - Health Promotion
KW  - Intervention
KW  - Mental Disorders
KW  - Mental Health
KW  - Prevention
KW  - Experimentation
KW  - Methodology
KW  - 1992
DO  - 10.1111/1467-8721.ep10768945
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-15425-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1994-06997-001
AN  - 1994-06997-001
AU  - Nayfield, S. G.
AU  - Ganz, P. A.
AU  - Moinpour, C. M.
AU  - Cella, D. F.
AU  - Hailey, B. J.
T1  - Report from a National Cancer Institute (USA) workshop on quality of life assessment in cancer clinical trials.
JF  - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JO  - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JA  - Qual Life Res
Y1  - 1992/06//
VL  - 1
IS  - 3
SP  - 203
EP  - 210
CY  - Germany
PB  - Springer
SN  - 0962-9343
SN  - 1573-2649
N1  - Accession Number: 1994-06997-001. PMID: 1363776 Partial author list: First Author & Affiliation: Nayfield, S. G.; NIH National Cancer Institute, Community Oncology & Rehabilitation Branch, Bethesda, MD, US. Release Date: 19940201. Correction Date: 20130225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Measurement; Neoplasms; Quality of Life; Treatment. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). Page Count: 8. Issue Publication Date: Jun, 1992. 
AB  - Reports the recommendations from the National Cancer Institute Workshop on quality of life (QOL) assessment in cancer clinical trials. The workshop focused specifically on identification of, methodological problems in, and implementation of clinical studies with QOL end points, as well as statistical issues in design, data analysis, and implementation. Workshop participants agreed that QOL is a multidimensional concept that should be evaluated by a set instrument addressing broad areas of patient functioning. The patient is the best source of QOL information. More than 1 measurement time is necessary. There should be a limited number of hypotheses; special training in QOL research is necessary. Statistical expertise is needed early in trial design. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - recommendations from National Cancer Institute Workshop on quality of life assessment in clinical treatment trials
KW  - cancer patients
KW  - 1992
KW  - Measurement
KW  - Neoplasms
KW  - Quality of Life
KW  - Treatment
KW  - 1992
DO  - 10.1007/BF00635619
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1994-06997-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Medda, Sukumar
AU  - Proia, Richard L.
T1  - The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1992/06/15/
VL  - 206
IS  - 3
M3  - Article
SP  - 801
EP  - 806
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Resident proteins of the endoplasmic reticulum lumen are continuously retrieved from an early Golgi compartment by a receptor-mediated mechanism. The sorting or retention sequence on the endoplasmic reticulum proteins is located at the C-terminus and was initially shown to be the tetrapeptide KDEL in mammalian cells and HDEL in Saccharomyces cerevisiae. The carboxylesterases are a large family of enzymes primarily localized to the lumen of the endoplasmic reticulum. Retention sequences in these proteins have been difficult to identify due to atypical and heterogeneous C-terminal sequences. Utilizing the polymerase chain reaction with degenerate primers, we have identified and characterized the C-termini of four members of the carboxylesterase family from rat liver. Three of the carboxylesterases sequences contained C-terminal sequences (HVEL, HNEL or HTEL) resembling the yeast sorting signal which were reported to be non-functional in mammalian cells. A fourth carboxylesterase contained a distinct C-terminal sequence, TEHT. A full-length esterase cDNA clone, terminating in the sequence HVEL, was isolated and was used to assess the retention capabilities of the various esterase C-terminal sequences. This esterase was retained in COS1 cells, but was secreted when its C-terminal tetrapeptide, HVEL, was deleted. Addition of C-terminal sequences containing HNEL and HTEL resulted in efficient retention. However, the C-terminal sequence containing TEHT was not a functional retention signal. Both HDEL, the authentic yeast retention signal, and KDEL were efficient retention sequences for the esterase. These studies show that some members of the rat liver carboxylesterase family contain novel C-terminal retention sequences that resemble the yeast signal. At least one member of the family does not contain a Cterminal retention signal and probably represents a secretory form. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENDOPLASMIC reticulum
KW  - ESTERASES
KW  - PROTEINS
KW  - POLYMERASE chain reaction
KW  - AMINO acid sequence
KW  - LIVER
N1  - Accession Number: 13682060; Medda, Sukumar 1 Proia, Richard L. 1; Affiliation:  1: Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA; Source Info: 6/15/92, Vol. 206 Issue 3, p801; Subject Term: ENDOPLASMIC reticulum; Subject Term: ESTERASES; Subject Term: PROTEINS; Subject Term: POLYMERASE chain reaction; Subject Term: AMINO acid sequence; Subject Term: LIVER; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Caughman, S. Wright
AU  - Li, Lian-Jie
AU  - Degitz, Klaus
T1  - Human Intercellular Adhesion Molecule-1 Gene and Its Expression in the Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/06/15/Jun92 Supplement
VL  - 98
IS  - 6
M3  - Article
SP  - 61S
EP  - 65S
SN  - 0022202X
AB  - Cell adhesion molecules are cell-surface proteins that allow specific cell-cell interactions among leukocytes, as well as between leukocytes and other cells. Recent studies have shown that the differential expression of selected cell-adhesion molecules plays a critical role in cutaneous inflammation, immunologic responses, and wound repair. Intercellular adhesion molecule-1 (ICAM-1) is a cell-adhesion molecule that is constitutively expressed on human dermal microvascular endothelial cells (HDMEC) and is inducible on human keratinocytes (HK). Its regulated expression is vital to the initiation and evolution of localized inflammatory processes in the skin. ICAM-1 serves as a specific ligand for lymphocyte function-associated antigen-1 (LFA-1), a cell-surface protein expressed on all leukocytes. The regulated expression of ICAM-1 allows leukocytes to bind to endothelial cells at sites of inflammation and, after exiting into the tissue, to interact with specific target cells, such as HK. Furthermore, specific cytokines are capable of differentially regulating ICAM-1 expression on HDMEC, HK, and other cells. The biologic relevance of ICAM-1 expression in cutaneous inflammation is further supported by functional studies demonstrating the critical role of ICAM-1/LFA-1 interactions in mediating the binding of peripheral blood leukocytes to HDMEC and to HK - cells known to be participants and targets in specific cutaneous immunologic responses. Thus, the delineation of precise molecular mechanisms that regulate the tissue-specific and cytokine-specific expression if ICAM-1 is important to both our understanding of the biology of localized inflammation and to the development of directed anti-inflammatory therapeutic strategies. Current evidence indicates that ICAM-1 expression is regulated at the level of gene transcription. Recently our laboratory has isolated and characterized a human genomic clone that contains the 5' regulatory region of the ICAM-1 gene. In the current studies, we further describe the genomic ICAM-1 clones isolated to date and demonstrate the presence of consensus regulatory elements located within the 5' flanking region of the ICAM-1 gene that are potentially involved in regulating ICAM-1 gene transcription. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL adhesion
KW  - LEUCOCYTES
KW  - GENE expression
KW  - SKIN diseases
KW  - ENDOTHELIAL seeding
KW  - LYMPHOCYTES
KW  - ANTIGENS
KW  - INFLAMMATION
KW  - GENETIC transformation
KW  - GENOMICS
KW  - PROTEIN kinases
KW  - IMMUNOLOGY
KW  - MOLECULES
KW  - DERMIS
N1  - Accession Number: 12462226; Caughman, S. Wright 1,2 Li, Lian-Jie 1,2 Degitz, Klaus 3; Affiliation:  1: Department of Dermatology, Veteran Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: Dermatologische Klinik und Poliklinik, Munich, Germany; Source Info: Jun92 Supplement, Vol. 98 Issue 6, p61S; Subject Term: CELL adhesion; Subject Term: LEUCOCYTES; Subject Term: GENE expression; Subject Term: SKIN diseases; Subject Term: ENDOTHELIAL seeding; Subject Term: LYMPHOCYTES; Subject Term: ANTIGENS; Subject Term: INFLAMMATION; Subject Term: GENETIC transformation; Subject Term: GENOMICS; Subject Term: PROTEIN kinases; Subject Term: IMMUNOLOGY; Subject Term: MOLECULES; Subject Term: DERMIS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12462226
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Accili, Domenico
AU  - Barbetti, Fabrizio
AU  - Cama, Alessandro
AU  - Kadowaki, Hiroko
AU  - Kadowaki, Takashi
AU  - Imano, Eiichi
AU  - Levy-Toledano, Rachel
AU  - Taylor, Simeon I.
T1  - Mutations in the Insulin Receptor Gene in Patients with Genetic Syndromes of Insulin Resistance and Acanthosis Nigricans.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/06/15/Jun92 Supplement
VL  - 98
IS  - 6
M3  - Article
SP  - 77S
EP  - 81S
SN  - 0022202X
AB  - Mutations of the insulin receptor gene have been identified in patients with genetic syndromes of insulin resistance associated with acanthosis nigricans. These mutations impair insulin responses by reducing the number of insulin receptors on the surface of target cells, or by reducing the receptor's ability to bind insulin or to undergo insulin-stimulated autophosphorylation, an important step in insulin action. Studies of mutant receptors expressed in transfection systems have contributed to our understanding of the structure-function relationships of the insulin receptor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ACANTHOSIS nigricans
KW  - GENETIC regulation
KW  - SYMPTOMS
KW  - GENETIC disorders
KW  - INSULIN receptors
KW  - PHOSPHORYLATION
N1  - Accession Number: 12462281; Accili, Domenico 1 Barbetti, Fabrizio 1 Cama, Alessandro 1 Kadowaki, Hiroko 1 Kadowaki, Takashi 1 Imano, Eiichi 1 Levy-Toledano, Rachel 1 Taylor, Simeon I. 1; Affiliation:  1: Diabetes Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun92 Supplement, Vol. 98 Issue 6, p77S; Subject Term: ACANTHOSIS nigricans; Subject Term: GENETIC regulation; Subject Term: SYMPTOMS; Subject Term: GENETIC disorders; Subject Term: INSULIN receptors; Subject Term: PHOSPHORYLATION; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12462281
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zahm, Shelia Hoar
AU  - Weisenburger, Dennis D.
AU  - Babbitt, Paula A.
AU  - Saal, Robert C.
AU  - Vaught, Jimmie B.
AU  - Blair, Aaron
T1  - Use of Hair Coloring Products and the Risk of Lymphoma, Multiple Myeloma, and Chronic Lymphocytic Leukemia.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/07//
VL  - 82
IS  - 7
M3  - Article
SP  - 990
EP  - 998
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Hair coloring products are widely used and contain components that are mutagenic and carcinogenic. An association between occupational exposure to hair coloring products and hematopoietic cancers has been reported, but the risk for these cancers among users has not been carefully evaluated. Methods. We conducted a population-based, case-control study with telephone interviews from 385 non-Hodgkin's lymphoma cases, 70 Hodgkin's disease cases, 72 multiple myeloma cases, 56 chronic lymphocytic leukemia cases, and 1432 controls. Results Among women, use was associated with odds ratios of 1.5 for non-Hodgkin's lymphoma, 1.7 for Hodgkin's disease, 1.8 for multiple myeloma, and 1.0 for chronic lymphocytic leukemia. Risk was higher for permanent hair coloring products than for semi- or nonpermanent products, particularly for dark colors. Long duration and early age of first use tended to increase risk, but the patterns were inconsistent. Use was much less common in men and did not significantly increase risk. Conclusions. The use of hair coloring products appears to increase the risk of non-Hodgkin's lymphoma. Multiple myeloma and Hodgkin's disease were also associated, although based on far fewer subjects. If these results represent a causal association, use of hair coloring products would account for 35% of non-Hodgkin's lymphoma cases in exposed women and 20% in all women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR -- Dyeing & bleaching
KW  - LYMPHOMAS
KW  - PLASMACYTOMA
KW  - LYMPHOCYTIC leukemia
KW  - CHRONIC diseases
KW  - CANCER
N1  - Accession Number: 9208170779; Zahm, Shelia Hoar 1 Weisenburger, Dennis D. 2,3 Babbitt, Paula A. Saal, Robert C. 4 Vaught, Jimmie B. 4 Blair, Aaron 1; Affiliation:  1: Occupational Studies Section, National Cancer Institute, Rockville, Md.  2: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha  3: Eppley Institute for Research in Cancer and Allied Diseases  4: Westal Inc, Rockville, Md.; Source Info: Jul1992, Vol. 82 Issue 7, p990; Subject Term: HAIR -- Dyeing & bleaching; Subject Term: LYMPHOMAS; Subject Term: PLASMACYTOMA; Subject Term: LYMPHOCYTIC leukemia; Subject Term: CHRONIC diseases; Subject Term: CANCER; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kanno, H.
AU  - Nose, M.
AU  - Itoh, J.
AU  - Taniguchi, Y.
AU  - Kyogoku, M.
T1  - Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1992/07//
VL  - 89
IS  - 1
M3  - Article
SP  - 68
EP  - 73
PB  - Wiley-Blackwell
SN  - 00099104
AB  - MRL/Mp mice are known to have autoimmune disease-prone genetic background, which contributes to the development of a lethal autoimmune disease at an early age in association with the lymphoproliferative gene, <em>lpr</em>. In this study, we found that MRL/Mp mice, not bearing <em>lpr</em> (MRL/Mp-+/+), spontaneously developed pancreatitis at a late stage of life, which was histopathologically characterized by destruction of pancreatic acinar cells with mononuclear cell infiltration. In female 34-38-weeks-old mice the incidence of pancreatitis reached 74%, whereas the male mice developed the disease with a reduced incidence, at a later stage of life and with a reduced severity. Cell infiltrates in the affected lesions were composed predominantly of CD4+ cells and to lesser extent Mac-2+ macrophages. Adoptive transfer of the spleen cells obtained from pancreatitis-bearing female mice generated pancreatitis in female normal mice, but not in the male mice. Transfer of the serum of pancreatitis-bearing mice failed to induce any pancreatic lesions. These findings indicate that pancreatitis in MRL/Mp-+/+ mice may be mediated by cellular autoimmune mechanism. This may present a useful concept for analysis of the developmental mechanisms of human chronic pancreatitis in an aspect of autoimmunity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PANCREATITIS
KW  - CELLS
KW  - AUTOIMMUNITY
KW  - IMMUNOLOGIC diseases
KW  - AUTOIMMUNE diseases
KW  - EXOCRINE glands
KW  - PANCREAS -- Cytology
KW  - adoptive transfer
KW  - autoimmune pancreatitis
KW  - lupus mice
N1  - Accession Number: 19023309; Kanno, H. 1,2 Nose, M. 1 Itoh, J. 1 Taniguchi, Y. 1 Kyogoku, M. 1; Affiliation:  1: Department of Pathology, Tohoku University School of Medicine, Sendai, Japan  2: Laboratory of Persistent Viral Disease, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA; Source Info: Jul1992, Vol. 89 Issue 1, p68; Subject Term: PANCREATITIS; Subject Term: CELLS; Subject Term: AUTOIMMUNITY; Subject Term: IMMUNOLOGIC diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: EXOCRINE glands; Subject Term: PANCREAS -- Cytology; Author-Supplied Keyword: adoptive transfer; Author-Supplied Keyword: autoimmune pancreatitis; Author-Supplied Keyword: lupus mice; Number of Pages: 6p; Illustrations: 4 Diagrams, 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Inada, Toshiya
AU  - Koshiishi, Mika
AU  - Ohnishi, Kimio
AU  - Yagi, Gohei
T1  - The Life Expectancy of Schizophrenic Patients with Tardive Dyskinesia.
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1992/07//Jul/Aug92
VL  - 7
IS  - 4
M3  - Article
SP  - 249
EP  - 254
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - Relationships between tardive dyskinesia (TD) and the life expectancy of schizophrenic patients who suffer it were examined in two studies over a 50-month period, in a prospective study, the mortality rate was found to be higher in patients with TD than in those without. This suggests either that TD is a factor tending to precipitate death, or else that it is an indication that the final period of life has been reached. The failure in the prospective study to detect medical factors which would discriminate between those TD patients who died and those who remained alive, as well as the finding of a significantly older age at death of patients with TD in the retrospective study may both support this idea. No significant differences were observed in the retrospective study in the prevalence or TD between 35 pairs of age-matched deceased and living patients. The effects of TD on life expectancy are subtle; the present results are consistent with the possibilities both that TD reduces life expectancy and that it appears at the end-stage of life. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human Psychopharmacology: Clinical & Experimental is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIFE expectancy
KW  - SCHIZOPHRENICS
KW  - TARDIVE dyskinesia
KW  - MORTALITY
KW  - LONGEVITY
KW  - TERMINALLY ill
KW  - life expectancy
KW  - mortality
KW  - schizophrenia.
KW  - Tardive dyskinesia
N1  - Accession Number: 12384033; Inada, Toshiya 1 Koshiishi, Mika 2 Ohnishi, Kimio 1 Yagi, Gohei 1; Affiliation:  1: National Center of Neurology and Psychiatry, National Institute of Mental Health, 1-7-3 Konodai, Ichikawa, Chiba 272, Japan  2: Department of Neuropsychiatry, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan; Source Info: Jul/Aug92, Vol. 7 Issue 4, p249; Subject Term: LIFE expectancy; Subject Term: SCHIZOPHRENICS; Subject Term: TARDIVE dyskinesia; Subject Term: MORTALITY; Subject Term: LONGEVITY; Subject Term: TERMINALLY ill; Author-Supplied Keyword: life expectancy; Author-Supplied Keyword: mortality; Author-Supplied Keyword: schizophrenia.; Author-Supplied Keyword: Tardive dyskinesia; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costa, J. J.
AU  - Keffer, J. M.
AU  - Goff, J. P.
AU  - Metcalfe, D. D.
T1  - Aphidicolin-induced proliferative arrest of murine mast cells: morphological and biochemical changes are not accompanied by alterations in cytokine gene induction.
JO  - Immunology
JF  - Immunology
Y1  - 1992/07//
VL  - 76
IS  - 3
M3  - Article
SP  - 413
EP  - 421
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Investigations of mast cell biology have often used immortalized cultured cells which are continuously proliferating. In vivo, however, only 2% or fewer tissue mast cells are actively dividing. We used aphidicolin, an inhibitor of DNA polymerase to induce a proliferative arrest of murine mast cells characterized by an inhibition of cell division and thymidine incorporation, with accumulation of cells in Gl and early S phase of the cell cycle. Uridine incorporation and cell viability were not significantly impaired. DNA synthesis and cell division both resumed rapidly upon removal of the drug. Morphometric analysis demonstrated that cell size, granule size, and number of granules per cell were all increased in aphidicolin-treated cells. Proliferative arrest also produced a 14-fold increase in cellular histamine content, but did not alter the proteoglycans synthesized by the cell. The level of c-myc mRNA was reduced in aphidicolin-arrested cells, but returned to the level observed in untreated cells within 1 hr of removal of the drug. In contrast, the constitutive steady-state RNA levels of tumour necrosis factor-α (TNF-α). B2-microglobulin, actin, and the c-Ha-ras and c-fes proto-oncogenes were not altered. Aphidicolin-induced proliferative arrest did not prevent the induction of TNF-2, interleukin-6 (IL-6) and c-fos genes in response to calcium ionophore. Both the magnitude and induction kinetics of these messages were similar in aphidicolin-treated and untreated cells. We conclude that proliferative arrest results in morphological and biochemical changes suggestive of cellular maturation, but inhibition of cell division alone is not sufficient to alter mast cell phenotype. Although optimal c-myc expression appears to require active proliferation, cytokine gene induction can occur in non-dividing cells. These data suggest that the proliferative quiescence of in vivo mast cells should not preclude their involvement in biological events via elaboration of multi-functional cytokines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cells
KW  - CYTOKINES
KW  - CELL culture
KW  - DNA polymerases
KW  - CELL division (Biology)
KW  - THYMIDINE
KW  - BIOCHEMISTRY
N1  - Accession Number: 14491193; Costa, J. J. 1 Keffer, J. M. 1 Goff, J. P. 2 Metcalfe, D. D. 1; Affiliation:  1: Mast Cell Physiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda  2: Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland, U.S.A.; Source Info: Jul92, Vol. 76 Issue 3, p413; Subject Term: MAST cells; Subject Term: CYTOKINES; Subject Term: CELL culture; Subject Term: DNA polymerases; Subject Term: CELL division (Biology); Subject Term: THYMIDINE; Subject Term: BIOCHEMISTRY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Muehrer, Peter
AU  - Koretz, Doreen S.
T1  - Methodological Linkages for Preventive Intervention Research: Proceedings of a Workshop.
JO  - Journal of Community Psychology
JF  - Journal of Community Psychology
Y1  - 1992/07//
VL  - 20
IS  - 3
M3  - Article
SP  - 257
EP  - 267
PB  - John Wiley & Sons, Inc.
SN  - 00904392
AB  - A recent National Institute of Mental Health workshop examined several prominent conceptual models as guides to high-quality preventive intervention research. The conceptual models were compared in terms of four methodological issues, i.e., specifying outcomes to be measured, specifying risk factors or change mechanisms, identifying intervention participants, and designing interventions. This article highlights answers to the methodological linkage questions from the point of view of various models and their implications for preventive intervention research. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OPERANT behavior
KW  - MENTAL health
KW  - OUTCOME assessment (Medical care)
KW  - DISEASES -- Risk factors
KW  - CONDITIONED response
KW  - MEDICAL care
N1  - Accession Number: 11976564; Muehrer, Peter 1 Koretz, Doreen S. 1; Affiliation:  1: Prevention Research Branch, Division of Clinical Research, National Institute of Mental Health.; Source Info: Jul92, Vol. 20 Issue 3, p257; Subject Term: OPERANT behavior; Subject Term: MENTAL health; Subject Term: OUTCOME assessment (Medical care); Subject Term: DISEASES -- Risk factors; Subject Term: CONDITIONED response; Subject Term: MEDICAL care; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Aimin Tang
AU  - Udey, Mark C.
T1  - Effects of Ultraviolet Radiation on Murine Epidermal Langerhans Cells: Doses of Ultraviolet Radiation that Modulate ICAM-1 (CD54) Expression and Inhibit Langerhans Cell Function Cause Delayed Cytotoxicity In Vitro.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/07//
VL  - 99
IS  - 1
M3  - Article
SP  - 83
EP  - 89
SN  - 0022202X
AB  - Low doses (100 J/m²) of ultraviolet B (UVB) radiation from Sunlamp fluorescent FS20 tubes inhibit the ability of freshly isolated murine epidermal Langerhans cells (LC) to support anti-CD3 MoAb-induced T-cell mitogenesis and selectively inhibit the upregulation of ICAM-1 expression by LC without causing appreciable cytotoxicity in short-term (≤ 24 h) incubations (J Immunol 146:3347-3355, 1991). In the present study epidermal cells (EC) were exposed to UVB radiation or were sham-irradiated and cultured for 24, 48, or 72 h when LC were recovered, enumerated, and assayed for simultaneous expression of I-A antigens and ICAM-1 by flow cytometry. UVB-irradiated LC that had been cultured for 24 h exhibited levels of I-A antigens comparable to those on unirradiated LC but expressed substantially less ICAM-1. After 48 and 72 h, cultured UVB-irradiated LC expressed somewhat lower levels of I-A antigens and markedly less ICAM-1 than unirradiated controls. Although similar numbers of LC were recovered from cultures initiated with UVB-irradiated and unirradiated epidermal cells after 24 h, far fewer identifiable LC were recovered from cultures seeded with irradiated cells at 48 and 72 h (∼50 and ∼10% of control respectively). The effect of UVB radiation on the survival of LC in vitro was not reversible with exogenous TNFα (125 U/ml) alone or granulocyte/macrophage colony-stimulating factor (5 ng/ml) and IL-1 (50 U/ml) in combination, although these cytokines had modest effects on the expression of I-A antigens and ICAM-1 by cultured UVB-irradiated LC. Results of survival studies performed with enriched LC preparations demonstrated that UVB radiation was clearly cytotoxic for LC and did not merely downregulate surface expression of I-A antigens or alter LC buoyant density.  Exposure of LC to radiation from blacklight fluorescent (UVA) tubes (0.25 J/cm2) in the presence of 8-methoxypsoralen (1 μ<em>g</em>/ml; PUVA) or monochromatic UVC radiationt (so J/m2) also inhibited LC accessory all function. Results of survival studies performed with EC that had been exposed to PUVA or UVC radiation before culture were similar to those of studies performed with UVB-irradiated cells, although PUVA- and UVC-induced LC cytotoxicity was much more pronounced 48 h after culture initiation then UVB-induced cytotoxicity-UVA radiation alone augmented LC recovery at 24 h and 48 h, but did not influence I-A antigen of ICAM-1 expression.  The results of these experiments indicate that levels of UV radiation (UVB, UVC, or psoralen + UVA radiation) that inhibit LC accessory cell function and selectively modulate ICAM-1 expression in short-term (≤ 24 h) cultures are ultimately cytotoxic for LC. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRAVIOLET radiation
KW  - RADIATION
KW  - LANGERHANS cells
KW  - EPIDERMIS
KW  - T cells
KW  - ANTIGENS
N1  - Accession Number: 12611871; Aimin Tang 1 Udey, Mark C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul92, Vol. 99 Issue 1, p83; Subject Term: ULTRAVIOLET radiation; Subject Term: RADIATION; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; Subject Term: T cells; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12611871
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bhat, Mohandas
AU  - Nelson, Karin B.
AU  - Cummins, Susan K.
AU  - Grether, Judith K.
T1  - Prevalence of developmental enamel defects in children with cerebral palsy.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1992/07//
VL  - 21
IS  - 6
M3  - Article
SP  - 241
EP  - 244
SN  - 09042512
AB  - Enamel defects observed in primary anterior teeth of 123 children with congenital cerebral palsy (CP) born 1983 through 1985 in four northern California counties were categorized using an adaptation of the Developmental Defects of Enamel Index. Nineteen children (15%) had crowns or loss of tooth substance (LTS) due to attrition. Missing enamel (ME) including horizontal groove, was observed in 39 children (32%,). Twenty-four children without ME (20%) had enamel pits, vertical grooves, or colored enamel opacities. Forty-one (33%) had clinically normal enamel. ME children did not differ significantly from those with normal enamel with respect to face, sex, singleton vs twin, severity or type of CP, or presence of dysmorphic features. ME children more often had shorter gestational ages than children with normal enamel. More ME children, even those who were not low in birth weight, were reported by parents to have required neonatal intensive care. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INCISORS
KW  - CEREBRAL palsy
KW  - ENAMEL & enameling
KW  - JUVENILE diseases
KW  - CRITICAL care medicine
KW  - SPASTIC paralysis
KW  - cerebral palsy
KW  - dental enamel
KW  - enamel defects
KW  - enamel hypoplasia.
N1  - Accession Number: 11655746; Bhat, Mohandas 1 Nelson, Karin B. 2 Cummins, Susan K. 3 Grether, Judith K. 4; Affiliation:  1: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, Bethesda, Maryland  2: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland  3: Environmental Epidemiology & Toxicology Branch, Emeryville, California, USA  4: California Birth Defects Monitoring Program, California Department of Health Services, Emeryville, California, USA; Source Info: Jul1992, Vol. 21 Issue 6, p241; Subject Term: INCISORS; Subject Term: CEREBRAL palsy; Subject Term: ENAMEL & enameling; Subject Term: JUVENILE diseases; Subject Term: CRITICAL care medicine; Subject Term: SPASTIC paralysis; Author-Supplied Keyword: cerebral palsy; Author-Supplied Keyword: dental enamel; Author-Supplied Keyword: enamel defects; Author-Supplied Keyword: enamel hypoplasia.; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Belland, R. J.
AU  - Chen, T.
AU  - Swanson, J.
AU  - Fischer, S. H.
T1  - Human neutrophil response to recombinant neisserial Opa proteins.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992/07//
VL  - 6
IS  - 13
M3  - Article
SP  - 1729
EP  - 1737
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Interactions of human neutrophils with recombinant <em>Escherichia coli</em> expressing gonococcal outer membrane Opa proteins were examined using chemiluminescent and biological assays. Seven opa loci from <em>Neisseria gonorrhoeae</em> MS11 4.8 were expressed as β-lactamase-Opa fusion proteins that contained all but the mature <em>N</em>-terminal amino acid of the full-length Opa protein fused to three N-terminal amino acids derived from the mature β-lactamase. The Opa fusion proteins were exported and assembled in the outer membrane of <em>E. coli</em> in a manner similar to that of Opa in <em>N. gonorrhoeae</em>, as evaluated by antibody binding and in situ proteolytic cleavage. All fusion proteins exhibited the characteristic heat-modifiable migration in SDS--polyacrylamide gel electrophoresis that typifies Opa proteins of neisseriae. Opa fusion proteins conferred on <em>E. coli</em> the ability to stimulate a chemiluminescent response from human neutrophils in the absence of antibody or complement. The nature of the response in terms of chemiluminescence, phagocytosis, and killing was in all cases analogous to that seen using <em>N. gonorrhoeae</em> expressing the equivalent Opa protein. Neither E. coli nor gonococci expressing OpaA elicited a response from neutrophils. Use of <em>E. coli</em> expressing Opa fusions should be useful in defining their biological activities and pathogenic roles. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Neutrophils
KW  - Granulocytes
KW  - Proteins
KW  - Amino acids
KW  - Biochemistry
N1  - Accession Number: 16177335; Belland, R. J. 1; Chen, T. 1; Swanson, J. 1; Fischer, S. H. 1; Affiliations: 1: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA; Issue Info: Jul1992, Vol. 6 Issue 13, p1729; Thesaurus Term: Escherichia coli; Subject Term: Neutrophils; Subject Term: Granulocytes; Subject Term: Proteins; Subject Term: Amino acids; Subject Term: Biochemistry; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Phipps, Kim
AU  - Baker, Karen
AU  - Evans, Christine
T1  - Unit-Based Clinical Nurse Specialist: Redesigning Nursing Services.
JO  - Nursing Economic$
JF  - Nursing Economic$
Y1  - 1992/07//Jul/Aug92
VL  - 10
IS  - 4
M3  - Article
SP  - 260
EP  - 264
PB  - Jannetti Publications, Inc.
SN  - 07461739
AB  - Medical Nursing services of Baltimore, Maryland-based Johns Hopkins Hospital has redesigned its delivery of direct nursing care. As a result, staff nurses are now empowered to deliver patient care through the assistance of nursing support technicians. The unit-based clinical nurse specialist was introduced, in a budget neutral manner, to provide nursing staff with on-site clinical expertise while serving as a professional role model. Competition with other health care agencies, service industries, a general labor shortage and career prospects for women have decreased the availability of nurses and ancillary staff.
KW  - NURSING service administration
KW  - NURSING
KW  - EMPLOYEE empowerment
KW  - MENTORING in nursing
KW  - PERSONNEL management
KW  - BALTIMORE (Md.)
KW  - MARYLAND
KW  - UNITED States
N1  - Accession Number: 12185541; Phipps, Kim 1 Baker, Karen 2 Evans, Christine 3; Affiliation:  1: Clinical Nurse, Johns Hopkins Hospital, Baltimore, MD.  2: Clinical Nurse Educator, National Institutes of Health, Bethesda, MD.  3: Director of Nursing, Johns Hopkins Hospital, Baltimore, MD.; Source Info: Jul/Aug92, Vol. 10 Issue 4, p260; Subject Term: NURSING service administration; Subject Term: NURSING; Subject Term: EMPLOYEE empowerment; Subject Term: MENTORING in nursing; Subject Term: PERSONNEL management; Subject Term: BALTIMORE (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2008-13497-007
AN  - 2008-13497-007
AU  - Soncrant, Timothy T.
AU  - Holloway, Harold W.
AU  - Horwitz, Barry
AU  - Rapoport, Stanley L.
AU  - Lamour, Yvon A.
T1  - Effect of nucleus basalis magnocellularis ablation on local brain glucose utilization in the rat: Functional brain reorganization.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1992/07//
VL  - 4
IS  - 7
SP  - 653
EP  - 662
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Soncrant, Timothy T., National Institutes of Health, 10/6C 103, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13497-007. PMID: 12106329 Partial author list: First Author & Affiliation: Soncrant, Timothy T.; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20100719. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Cortex; Cholinergic Nerves; Glucose Metabolism; Nucleus Basalis Magnocellularis; Brain Lesions (Experimental). Minor Descriptor: Frontal Lobe; Parietal Lobe; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1992. Publication History: Accepted Date: Mar 9, 1992; Revised Date: Feb 10, 1992; First Submitted Date: Jul 25, 1991. Copyright Statement: European Neuroscience Association. 1992. 
AB  - After unilateral destruction of the nucleus basalis magnocellularis (NBM) in 3-month-old rats, which reduces cholinergic inputs to the ipsilateral frontoparietal neocortex, regional cerebral metabolic rates for glucose (rCMRglc) of denervated cortex are initially reduced, but nearly normalize by 2 weeks. To examine functional reorganization of the brain after unilateral destruction of the NBM, a correlation analysis of rCMRglc was performed on two groups of 16 young rats 2 weeks after stereotaxic ablation of the right NBM with ibotenate or sham surgery. rCMRglc was measured in 117 brain regions of awake rats with the [¹⁴C]deoxyglucose method. For each region pair, a partial correlation coefficient was calculated for rCMRglc across animals. Most correlations between cholinergic nuclei of both left and right forebrain (medial septum and diagonal band) and right (66/72, mean increase 0.44) but not left (39/72) frontoparietal cortical regions were larger (P < 0.001) in lesioned rats, as were those between most frontoparietal region pairs (516/630, P < 0.001). These results suggest that, after unilateral NBM ablation, (1) functional interactions are established between the remaining cholinergic forebrain and the deafferented cortex, (2) the neocortex becomes more integrated, and (3) functional reorganization involves both cortical hemispheres. These changes do not correspond to those reported to occur in Alzheimer's disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nucleus basalis magnocellularis ablation
KW  - brain
KW  - glucose utilization
KW  - rats
KW  - functional brain reorganization
KW  - cholinergic inputs
KW  - ipsilateral frontoparietal neocortex
KW  - 1992
KW  - Cerebral Cortex
KW  - Cholinergic Nerves
KW  - Glucose Metabolism
KW  - Nucleus Basalis Magnocellularis
KW  - Brain Lesions (Experimental)
KW  - Frontal Lobe
KW  - Parietal Lobe
KW  - Rats
KW  - 1992
DO  - 10.1111/j.1460-9568.1992.tb00174.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Hilakivi-Clarke, Leone A.
AU  - Lister, Richard G.
T1  - The Role of Body Weight in Resident-Intruder Aggression.
JO  - Aggressive Behavior
JF  - Aggressive Behavior
Y1  - 1992/08//
VL  - 18
IS  - 4
M3  - Article
SP  - 281
EP  - 287
PB  - John Wiley & Sons, Inc.
SN  - 0096140X
AB  - The behavior of male NIH Swiss mice of various body weights in the resident-intruder test of aggression was investigated. Mice were housed Individually for 10 days prior to the test, and allocated to six groups. In the first three groups body weights of residents and group-housed intruders were matched, and the animals were divided into light, average, or heavy groups. In the last three groups weights of the intruder mice were either matched with the residents, or intruders were lighter or heavier than the residents. We found that light residents spent significantly less (line in aggressive behaviours and longer time in defensive behaviors than the other two groups. The heavy mice showed most social investigation. The body weights of intruders were also shown to affect the behavior in the test: those residents which bad light opponents spent a longer time in aggressive behavior than those which had matched or heavy opponents. The resident mice with heavy opponents showed most defensive behaviors. To study whether pharmacological manipulation may have different effects on behavior in the resident-intruder test in mice having different weights, animals of light, average, and heavy body night received a low dose (0.8 g/kg) of ethanol 30 ruin prior to the test. We did not note any effect or ethanol on aggressive behavior in the three groups. The results suggest that body night plays a significant role In determining the level of aggression and defensive behaviors in the resident-intruder test. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Aggressive Behavior is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANIMAL behavior
KW  - BODY weight
KW  - AGGRESSION (Psychology)
KW  - DEFENSIVENESS (Psychology)
KW  - PHARMACOLOGY
KW  - MICE as laboratory animals
N1  - Accession Number: 11975620; Hilakivi-Clarke, Leone A. 1 Lister, Richard G. 1; Affiliation:  1: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bethesda, Maryland.; Source Info: 1992, Vol. 18 Issue 4, p281; Subject Term: ANIMAL behavior; Subject Term: BODY weight; Subject Term: AGGRESSION (Psychology); Subject Term: DEFENSIVENESS (Psychology); Subject Term: PHARMACOLOGY; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tsunenobu Tamura
AU  - Goldenberg, Robert L.
AU  - Freeberg, Larry E.
AU  - Cliver, Suzanne P.
AU  - Cutter, Gary R.
AU  - Hoffman, Howard J.
T1  - Maternal serum folate and zinc concentrations and their relationships to pregnancy outcome.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/08//
VL  - 56
IS  - 2
M3  - Article
SP  - 365
EP  - 370
SN  - 00029165
AB  - To evaluate the relationship between folate and zinc, and its effect on pregnancy outcome, maternal serum folate and zinc concentrations were determined at 1 8 and 30 wk gestation in a defined population of 285 pregnant women as part of a large-scale study to identify risk factors for fetal growth retardation (FOR). These results were correlated with birth weight and Apgar scores of newborn infants and with maternal infections during the perinatal period. A weak linear relationship was observed between maternal serum folate and zinc concentrations at 30 wk gestation. Folic acid supplementation had favorable effects on birth weight and Apgar scores of newborns, and reduced prevalence of FGR and maternal infections. No significant correlation was found between serum zinc concentration and birth weight of infants. The concept that folic acid supplementation has an adverse effect on maternal zinc nutriture and pregnancy outcome was not supported. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - Folic acid in human nutrition
KW  - Pregnant women
KW  - Fetal growth retardation
KW  - Zinc in the body
KW  - Birth weight
KW  - Apgar score
KW  - birth weight
KW  - Folate
KW  - pregnancy outcome
KW  - zinc
N1  - Accession Number: 94402435; Tsunenobu Tamura 1,2,3; Goldenberg, Robert L. 1,2,3; Freeberg, Larry E. 1,2,3; Cliver, Suzanne P. 1,2,3; Cutter, Gary R. 1,2,3; Hoffman, Howard J. 1,2,3; Affiliations: 1: Department of Nutrition Sciences and the Department of Obstetrics and Gynecology. University of Alabama at Birmingham, Birmingham, AL; 2: Pythagoras Inc, Birmingham, AL; 3: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Issue Info: Aug1992, Vol. 56 Issue 2, p365; Thesaurus Term: HEALTH; Subject Term: Folic acid in human nutrition; Subject Term: Pregnant women; Subject Term: Fetal growth retardation; Subject Term: Zinc in the body; Subject Term: Birth weight; Subject Term: Apgar score; Author-Supplied Keyword: birth weight; Author-Supplied Keyword: Folate; Author-Supplied Keyword: pregnancy outcome; Author-Supplied Keyword: zinc; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ferraro, Robert
AU  - Ravussin, Eric
AU  - Cunningham, John J.
T1  - Fat mass in predicting resting metabolic rate.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/08//
VL  - 56
IS  - 2
M3  - Letter to the Editor
SP  - 460
EP  - 461
SN  - 00029165
AB  - A letter to the editor is presented in response to the article "Body composition as a determinant of energy expenditure: A synthetic review and a proposed general prediction equation" by J.J. Cunningham in the 1991 issue.
KW  - Energy metabolism
KW  - Caloric expenditure
KW  - Human body composition
N1  - Accession Number: 94402419; Ferraro, Robert 1; Ravussin, Eric 1; Cunningham, John J. 2; Affiliations: 1: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Diabetes and Nutrition Section, 4212 North 16th Street, Phoenix, AZ 85016; 2: Department of Nutrition, College of Food and Natural Resources, University of Massachusetts at Amherst, Amherst, MA 01003; Issue Info: Aug1992, Vol. 56 Issue 2, p460; Thesaurus Term: Energy metabolism; Subject Term: Caloric expenditure; Subject Term: Human body composition; Number of Pages: 2p; Document Type: Letter to the Editor
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Punnonen, Kari
AU  - Yuspa, Stuart H.
T1  - Ultraviolet Light Irradiation Increases Cellular Diacylglycerol and Induces Translocation of Diacylglycerol Kinase in Murine Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/08//
VL  - 99
IS  - 2
M3  - Article
SP  - 221
EP  - 226
SN  - 0022202X
AB  - Cellular lipid metabolism can provide a variety of mediators of signal transduction, including diacylglycerols and inositol Phosphates. These factors may be involved in the control of epidermal differentiation and proliferation because they are modulated by extracellular calcium, which also regulates the maturation phenotype of cultured keratinocytes. The effect of non-cytotoxic exposures to ultraviolet light on lipid metabolism was studied in cultured murine keratinocytes. Ultraviolet treatment of cultured murine keratinocytes growing in 0.05 mM Ca++ did not significantly change the total amount of [³H]inositol phosphates at 0.5, 8, or 24 h post-irradiation. Irradiated cells responded to an increase from 0.05 mM Ca++ to 1.4 mM Ca++ medium with increased formation of inositol phosphates suggesting irradiation did not alter the normal inositol lipid turnover in response to the Ca++ signal for terminal differentiation. Irradiation (20- 120 J/m² of UVB) induced a dose-dependent increase in the cellular level of diacylglycerols as measured at 24 h post-irradiation, without changing the turnover of other phospholipids including phosphatidylcholine and phosphatidylethanolamine. The increased cellular levels of diacylglycerols following ultraviolet exposure were accompanied by changes in the activity of diacylglycerol kinase (DAG-kinase). The cytosolic DAG-kinase activity was decreased whereas the DAG-kinase activity in the membrane fraction was increased. These results suggest that ultraviolet irradiation increases the level of diacylglycerols via changes in de novo metabolism through a DAG-kinase pathway. Elevated diacylglycerol may influence signal-transduction pathways mediated by cellular lipids and contribute to some keratinocyte responses to ultraviolet light. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRAVIOLET radiation
KW  - IRRADIATION
KW  - KERATINOCYTES
KW  - LIPID metabolism
KW  - CALCIUM
KW  - CELLS
N1  - Accession Number: 12650445; Punnonen, Kari 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug92, Vol. 99 Issue 2, p221; Subject Term: ULTRAVIOLET radiation; Subject Term: IRRADIATION; Subject Term: KERATINOCYTES; Subject Term: LIPID metabolism; Subject Term: CALCIUM; Subject Term: CELLS; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12650445
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoelzel, A. R.
T1  - Conservation genetics of whales and dolphins.
JO  - Molecular Ecology
JF  - Molecular Ecology
Y1  - 1992/08//
VL  - 1
IS  - 2
M3  - Article
SP  - 119
EP  - 125
PB  - Wiley-Blackwell
SN  - 09621083
AB  - Whales and dolphins (cetaceans) are found in all the world's oceans and in some of the major rivers, yet little is known about the distribution and behaviour of many species. At the same time, cetaceans are under threat from a variety of pressures including direct and indirect takes, pollution, and competition for habitat and prey. To ensure their long-term survival it will be necessary to preserve genetic diversity through the identification and protection of differentiated populations, the assessment of variation within local populations, and through a better understanding of reproductive and dispersal behaviour. The application of molecular genetic techniques is helping to provide answers to some of these previously intractable questions. Early results suggest few consistent patterns. Obvious geographic boundaries correlate to genetic distance in some species, and not in others. Furthermore, morphological variation within species can be fairly extensive without correlating to genetic distance, or relatively minor between morphotypes that are as genetically distinct as some species. These examples emphasize the need for further study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Ecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Wildlife conservation
KW  - Whales
KW  - Dolphins
KW  - Cetacea
KW  - Variation (Biology)
KW  - Animal genetics
KW  - Animal genetic engineering
KW  - Molecular genetics
KW  - cetaceans
KW  - conservation
KW  - molecular genetics
KW  - stock identity
N1  - Accession Number: 18310677; Hoelzel, A. R. 1,2,3; Affiliations: 1: Department of Genetics, Cambridge University, Cambridge CB2 3EH; 2: NERC Centre for Population Biology, Silwood Park, Ascot SL5 7PY, UK; 3: LVC, National Cancer Institute, Frederick, MD 21702, USA; Issue Info: Aug1992, Vol. 1 Issue 2, p119; Thesaurus Term: Wildlife conservation; Thesaurus Term: Whales; Thesaurus Term: Dolphins; Thesaurus Term: Cetacea; Thesaurus Term: Variation (Biology); Subject Term: Animal genetics; Subject Term: Animal genetic engineering; Subject Term: Molecular genetics; Author-Supplied Keyword: cetaceans; Author-Supplied Keyword: conservation; Author-Supplied Keyword: molecular genetics; Author-Supplied Keyword: stock identity; NAICS/Industry Codes: 114111 Finfish Fishing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06463-007
AN  - 2006-06463-007
AU  - Shah, Saleem A.
T1  - Trials and Tribulations of the Insanity Defense.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1992/08//
VL  - 37
IS  - 8
SP  - 749
EP  - 752
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06463-007. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; National Institute of Mental Health, Division of Applied and Services Research, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Criminal Responsibility; Insanity Defense; Legal Processes; Mentally Ill Offenders. Minor Descriptor: Conflict; Punishment. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Reviewed Item: Finkel, Norman J. Insanity on Trial=New York: Plenum Press, 1988. 374 pp. $42.50; 1988. References Available: Y. Page Count: 4. Issue Publication Date: Aug, 1992. 
AB  - Reviews the book, Insanity on Trial by Norman J. Finkel (see record [rid]1988-98765-000[/rid]). This book has four main parts. The first part deals with the historical development of Anglo-American legal perspectives on exculpatory insanity and provides a useful discussion of some of the key questions and dilemmas that continue to be raised. The second part looks at various basic concepts such as mental illness, treatment issues, and considerations pertaining to punishment of the insane. The third part discusses the insanity defense from the perspectives of laypeople (or juries) and patient-defendants as well as from a neuropsychological perspective. The last section focuses on the topic of insanity and provides a defense of the insanity defense and Finkel's proposal 'for a unifying; coherent, and simpler doctrine'. The last chapter discusses some of the major dilemmas and conflicts in interactions between the legal and mental health systems. Although Finkel is correct in pointing to the bewildering complexity regarding the insanity defense and related doctrines, a lot of this reflects the fact that in our federal system the primary authority for the administration of justice rests with the states. Despite Finkel's aspiration to bring greater coherence and clarity to the special defense of insanity, there are several problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - insanity defense
KW  - trials
KW  - punishment
KW  - legal processes
KW  - not guilty by reason of insanity
KW  - mentally ill offenders
KW  - criminal responsibility
KW  - 1992
KW  - Criminal Responsibility
KW  - Insanity Defense
KW  - Legal Processes
KW  - Mentally Ill Offenders
KW  - Conflict
KW  - Punishment
KW  - 1992
U2  - Finkel, Norman J. (1988); Insanity on Trial; New York: Plenum Press, 1988. 374 pp. $42.50; 0-306-42899-7.
DO  - 10.1037/032430
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-33374-009
AN  - 2015-33374-009
AU  - Charnas, Lawrence R.
AU  - Szaro, Ben G.
AU  - Gainer, Harold
T1  - Identification and developmental expression of a novel low molecular weight neuronal intermediate filament protein expressed in Xenopus laevis.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1992/08//
VL  - 12
IS  - 8
SP  - 3010
EP  - 3024
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Charnas, Lawrence R., National Institutes of Health, Building 10, Room 93242, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-33374-009. PMID: 1494944 Partial author list: First Author & Affiliation: Charnas, Lawrence R.; Unit on Neurogenetics, Human Genetics Branch, NICHD, National Institutes of Health, Bethesda, MD, US. Release Date: 20160616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neural Development; Neurons; Proteins. Minor Descriptor: Animals; Stress. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Aug, 1992. Publication History: Accepted Date: Mar 10, 1992; Revised Date: Feb 25, 1992; First Submitted Date: Dec 16, 1991. Copyright Statement: Society for Neuroscience. 1992. 
AB  - Xenopus laevis is a valuable model system for the study of vertebrate neuroembryogenesis. However, very few well-characterized nervous system-specific molecular markers are available for studies in this organism. We screened a X. laevis adult brain cDNA library using a cDNA probe for mouse low molecular weight neurofilament protein (NF-L) in order to identify neuron-specific intermediate filament proteins. Clones for two distinct neuron-specific intermediate filament proteins were isolated and sequenced. One of these encoded for a Xenopus NF-L (XNF-L) and the other for a novel neuron-specific Xenopus intermediate filament protein (XNIF) that was present earlier and more abundantly than XNF-L during development. XNIF contained a central rod domain with multiple sequence features characteristic of IF proteins. The XNF-L was very similar to mouse NF-L, with a 77% sequence identity in the rod domain and the presence of a polyglutamic acid region in the tail domain, characteristic of type IV neurofilament proteins. In contrast, XNIF showed only 60% identity to mouse NF-L in the rod domain and lacked the glutamic acid-rich sequence in the tail domain. XNIF also had a very low (~38%) sequence identity in the head and tail domains as compared to NF-L and other neurofilament proteins (45% identity to the head domain of α-internexin). In the adult frog, XNIF mRNA is detected by Northern blots only within the nervous system and by in situ hybridization histochemistry exclusively in neurons, particularly in the medullary reticular system and spinal cord. Antisera raised against the unique tail region of XNIF detected a single distinct 60 kDa band in Western blots of nervous system cytoskeletal preparations, and this XNIF immunoreactivity was concentrated in axons in the PNS and in small perikarya in the dorsal root ganglion. In contrast, NF-L immunoreactivity was principally in the large perikarya in the dorsal root ganglion. In development, XNIF mRNA appears more abundant than XNF-L mRNA in all premetamorphic stages examined. XNIF mRNA is first detectable at stage 24 (26 hr), whereas stable expression of XNF-L is at stage 35/36 (50 hr). XNIF immunoreactivity is detectable within the cement gland, within many neuronal cell bodies and axon tracts within the developing nervous system, and within all cellular layers of the developing retina. The availability of these two distinct neuron-specific intermediate filament proteins, with different temporal and spatial expression patterns, should provide new markers as well as targets for functional perturbation in the developing X. laevis nervous system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - low molecular weight
KW  - neuronal intermediate filament
KW  - proteins
KW  - Xenopus laevis
KW  - 1992
KW  - Neural Development
KW  - Neurons
KW  - Proteins
KW  - Animals
KW  - Stress
KW  - 1992
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Woodgate, Roger
AU  - Sedgwick, Steven G.
T1  - Mutagenesis induced by bacterial UmuDC proteins and their plasmid homologues.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992/08/15/
VL  - 6
IS  - 16
M3  - Article
SP  - 2213
EP  - 2218
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The popular image of a world full of pollutants mutating DNA is only partly true since there are relatively few agents which can subtly and directly change base coding; for example, some alkylating agents alter guanine so that it pairs like adenine. Many more mutagens are less subtle and simply destroy coding altogether rather than changing it. Such mutagens include ultraviolet light, X-rays, DNA cross-linkers and other agents which make DNA breaks or large adducts. In <em>Escherichia coli</em>, mutagenesis by these agents occurs during a DNA repair process which increases cell survival but with an inherent possibility of changing the original sequence. Such mutagenic DNA repair is, in part, encoded by the <em>E. coli umuDC </em>operon. This article reviews the structure, function, regulation and evolution of the <em>umuDC </em>operon and similar genes found both in other species and on naturally occurring plasmids. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutagens
KW  - Mutation (Biology)
KW  - Escherichia coli
KW  - Mutagenesis
KW  - DNA
N1  - Accession Number: 17336431; Woodgate, Roger 1; Sedgwick, Steven G. 2; Affiliations: 1: Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Laboratory of Yeast Genetics, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK; Issue Info: Aug1992, Vol. 6 Issue 16, p2213; Thesaurus Term: Mutagens; Thesaurus Term: Mutation (Biology); Thesaurus Term: Escherichia coli; Subject Term: Mutagenesis; Subject Term: DNA; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Milne, G W A
T1  - DrawPerfect and CorelDraw
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1992/09//Sep-Oct 1992
VL  - 32
IS  - 5
M3  - Article
SP  - 570
EP  - 571
SN  - 00952338
AB  - This paper reviews two graphics programs, DrawPerfect and CorelDraw. DrawPerfect is a graphics editor which is provided as a companion to WordPerfect. Its graphics capabilities and text-graphic links are analyzed. CorelDraw's capabilities are also examined, in particular its management of color, which is considered a major attribute of the system. The author argues that both programs are useful, but have different strengths: DrawPerfect is recommended for scientific diagrams that are to be embedded into documents, and CorelDraw is recommended for producing advertising copy or brochures in which graphics and color are important.
KW  - EDITORS
KW  - GRAPHIC arts
KW  - Color
KW  - Computer programs
N1  - Accession Number: ISTA2703918; Milne, G W A 1; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: Sep-Oct 1992, Vol. 32 Issue 5, p570; Note: Update Code: 2700; Subject Term: EDITORS; Subject Term: GRAPHIC arts; Author-Supplied Keyword: Color; Author-Supplied Keyword: Computer programs; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Berger, Rudolf
AU  - Gartner, Suzanne
AU  - Rappersberger, Kiemens
AU  - Foster, Carolyn A.
AU  - Wolff, Klaus
AU  - Stingl, Georg
T1  - Isolation of Human Immunodeficiency Virus Type 1 from Human Epidermis: Virus Replication and Transmission Studies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/09//
VL  - 99
IS  - 3
M3  - Article
SP  - 271
EP  - 277
SN  - 0022202X
AB  - For a better understanding of the pathogenetic events operative in the cutaneous manifestations of human immunodeficiency virus type 1 (HIV-1) disease, we investigated whether epidermal cells (EC) from HIV-1 - seronegative persons can be infected with HIV-1 and , vice versa, whether HIV-1 can be rescued from the epidermis of HIV-1 - infected individuals. In a series of three experiments, we consistently found that exposure of EC from HIV-1 - seronegative donors to HIV-1 led to viral replication in these cells as evidenced by the detection of HIV-1 p24 in culture fluids. Because EC had been substantially enriched for Langerhans cells (LC) before being exposed to HIV-1, it is reasonable to assume that these CD1a+/CD4+/MHC class II+ antigen-presenting cells of the epidermis represented the actual targets of infection. This assumption is further strengthened by the observation that T cell - depleted cell suspensions from Langerhans cell histiocytosis (LCH) lesions could be productively infected with HIV-1. Conversely, co-culture of epidermal sheets from HIV-1 - seropositive individuals with monoculture phagocytes (MNP) from HIV-1 - seronegative donors resulted, after 3 to 5 weeks, in the detection of HIV-1 p24 in 12 of 23 cases. Immunocytochemical analysis, using a monoclonal antibody specific for p24, revealed the presence of HIV-1 in adherent MNP in three cocultures tested. In addition, cellular DNA from these cultures showed strong signals when hybridized to a HIV-1 - specific DNA probe. The further finding that two isolates examined exhibited different restriction enzyme patterns indicates that they are separate entities rather than contaminants. Transmission of these isolates to MNP, B-or T-cell lines resulted in cultures strongly positive for p24 and, in the case of H9 cells, for viral particles as detected by electron microscopy. Our results therefore strongly suggest that EC not only can serve as targets for HIV-1, but also can allow efficient virus replication and transmit HIV-1 to various cell types of the hematopietic lineage. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV (Viruses)
KW  - EPIDERMIS
KW  - VIRAL replication
KW  - LANGERHANS cells
KW  - HIV antibodies
KW  - HIV infections
KW  - ELECTRON microscopy
N1  - Accession Number: 12616619; Berger, Rudolf 1 Gartner, Suzanne 2 Rappersberger, Kiemens 1 Foster, Carolyn A. 1 Wolff, Klaus 1 Stingl, Georg 1; Affiliation:  1: Department of Dermatology I, Division of Cutaneous Immunobiology, University of Vienna Medical School, Vienna, Austria  2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Sep92, Vol. 99 Issue 3, p271; Subject Term: HIV (Viruses); Subject Term: EPIDERMIS; Subject Term: VIRAL replication; Subject Term: LANGERHANS cells; Subject Term: HIV antibodies; Subject Term: HIV infections; Subject Term: ELECTRON microscopy; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12616619
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Griffiths, Christopher E. M.
AU  - Rosenthal, Dean S.
AU  - Reddy, Ambati P.
AU  - Elder, James T.
AU  - Astrom, Anders
AU  - Leach, Katherine
AU  - Wang, Timothy S.
AU  - Finkel, Lawrence J.
AU  - Yuspa, Stuart H.
AU  - Voorhees, John J.
AU  - Fisher, Gary J.
T1  - Short-Term Retinoic Acid Treatment Increases In Vivo, but Decreases In Vitro, Epidermal Transglutaminase-K Enzyme Activity and Immunoreactivity.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/09//
VL  - 99
IS  - 3
M3  - Article
SP  - 283
EP  - 288
SN  - 0022202X
AB  - Epidermal transglutaminase-K is believed to catalyze the covalent linking of loricrin and involucrin to form cross-linked (CE) envelopes. In normal skin, transglutaminase-K is expressed as a band immediately below the stratum corneum, whereas in psoriasis and healing skin its expression is considerably expanded throughout the suprabasal layers. We have investigated whether the hyperproliferative state induced by short-term application of topical retinoic acid is similarly characterized by an increase in transglutaminase-K enzyme activity and immunoreactivity. Retinoic acid (0.1% cream) or vehicle were applied to human skin and occluded for 4 d. Skin biopsies were obtained for measurement of transglutaminase-K and transglutaminase-C activity and immunoreactivity. For comparison, cultured normal human keratinocytes were incubated for 4 d in the presence of 1 μM retinoic acid and the subsequent transglutaminase-K activity and immunoreactivity measured. Transglutaminase-K activity was increased 2.8 times in retinoic acid compared to vehicle-treated skin (p < 0.005, n = 12) whereas there was no significant difference in transglutaminase-C activity. However, transglutaminase-K mRNA levels were not significantly different between retinoic acid- and vehicle-treated skin. In vehicle-treated skin, transglutaminase-K immunoreactivity was limited to a narrow, substratum corneal band, but was considerably expanded in a diffuse suprabasal pattern in retinoic acid - treated epidermis. In contrast, transglutaminase-K immunostaining was decreased and its enzymatic activity reduced sixfold in retinoic acid - treated keratinocytes (p < 0.01, n = 4). These results demonstrate that retinoic acid treatment in vivo, in contrast to in vitro, leads to not only increased transglutaminase-K protein expression but also increased enzymatic activity in the absence of detectable increases in mRNA levels.These data, taken with the previously reported lack of keratinocyte terminal differentiation that are altered in vitro by retinoic acid do not occur in vivo in human skin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSGLUTAMINASES
KW  - TRETINOIN
KW  - SKIN -- Biopsy
KW  - KERATINOCYTES
KW  - MESSENGER RNA
KW  - ENZYMATIC analysis
KW  - PSORIASIS
KW  - THERAPEUTIC use
N1  - Accession Number: 12616626; Griffiths, Christopher E. M. 1 Rosenthal, Dean S. 2 Reddy, Ambati P. 1 Elder, James T. 1 Astrom, Anders 1 Leach, Katherine 1 Wang, Timothy S. 1 Finkel, Lawrence J. 1 Yuspa, Stuart H. 2 Voorhees, John J. 1 Fisher, Gary J. 1; Affiliation:  1: Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan  2: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Sep92, Vol. 99 Issue 3, p283; Subject Term: TRANSGLUTAMINASES; Subject Term: TRETINOIN; Subject Term: SKIN -- Biopsy; Subject Term: KERATINOCYTES; Subject Term: MESSENGER RNA; Subject Term: ENZYMATIC analysis; Subject Term: PSORIASIS; Subject Term: THERAPEUTIC use; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12616626
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rappersberger, Klemens
AU  - Roos, Norbert
AU  - Stanley, John R.
T1  - Immunomorphologic and Biochemical Identification of the Pemphigus Foliaceous Autoantigen Within Desmosomes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/09//
VL  - 99
IS  - 3
M3  - Article
SP  - 323
EP  - 330
SN  - 0022202X
AB  - Desmosomes are specialized domains of the plasma membrane that play a fundamental role in intercellular adhesion. This adhesive function is mediated at least in part by the cadherin homologous cell adhesion molecule (CAM) desmoglein (dg). Autoantibodies (aab) from patients with pemphigus foliaceous (pf), a blistering disease of the epidermis, have been shown by immunochemical methods to bind to desmoglein. However, the molecular localization of the binding sites of these antibodies, especially as it relates to the ultrastructure of the desmosomes, has not been definitively characterized. We therefore performed pre-embedding direct immunoelectron microscopy (IEM) on perilesional skin of patients with pf and post-embedding indirect IEM using sera from five patients with pf. We first confirmed by immunoprecipitation and immunoblotting that these sera bound dg. Both IEM methods showed that pf-aab exclusively bind to desmosomes. Double-labeling IEM of several other constitutive desmosomal proteins further suggests tint most likely pf-aab bind to an extracellular domain of the transmembrane CAM dg. Our studies suggest one possible pathophysiologic mechanism for the clinical manifestations of pf: namely, that the binding of aab to an extracellular epitope of desmoglein might impair the adhesive properties of desmosomes mediated by dg and result in the loss of cell adhesion leading to acantholysis and blister formation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOANTIBODIES
KW  - DESMOSOMES
KW  - CELL adhesion molecules
KW  - ANTI-immunoglobulin autoantibodies
KW  - SKIN diseases
KW  - CELL membranes
KW  - IMMUNOELECTROPHORESIS
N1  - Accession Number: 12616659; Rappersberger, Klemens 1,2 Roos, Norbert 1 Stanley, John R. 3; Affiliation:  1: Electronmicroscopic Laboratories of Biological Sciences, Department of Biology, University of Oslo, Oslo, Norway  2: Department of Dermatology I, University of Vienna, Vienna, Austria.  3: Dermatology Branch, National Institutes of Health, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Sep92, Vol. 99 Issue 3, p323; Subject Term: AUTOANTIBODIES; Subject Term: DESMOSOMES; Subject Term: CELL adhesion molecules; Subject Term: ANTI-immunoglobulin autoantibodies; Subject Term: SKIN diseases; Subject Term: CELL membranes; Subject Term: IMMUNOELECTROPHORESIS; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12616659
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cohen, Philip J.
AU  - Katz, Stephen I.
T1  - Cultured Human Langerhans Cells Process and Present Intact Protein Antigens.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/09//
VL  - 99
IS  - 3
M3  - Article
SP  - 331
EP  - 336
SN  - 0022202X
AB  - Epidermal Langerhans cells (LC) undergo profound phenotypic and functional alterations when cultured for 2 to 3 d. To determine whether the in vitro culture of human LC modulates their capacity to process and present intact protein antigens, we compared the ability of freshly isolated LC (fLC) and cultured LC (cLC) to stimulate in vitro T-cell proliferative responses to recall antigens. We found that human fLC and cLC were able to process and present recall antigens to primed T cells, inducing significant proliferative responses. For tetanus toxoid and <em>Candida albicans</em> extract, T-cell proliferative responses at 6 d to antigen-pulsed fLC were slightly greater than responses to antigen-pulsed cLC. For live influenza A virus, the T-cell responses induced by antigen-pulsed cLC were comparable or slightly greater compared with fLC. Allogeneic T-cell proliferation for both LC preparations were also comparable. The exogenous pathway of antigen processing was demonstrated by chloroquine inhibition. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - ANTIGENS
KW  - CELL proliferation
KW  - IMMUNOGLOBULINS
KW  - BLOOD proteins
KW  - HUMAN cell culture
N1  - Accession Number: 12616663; Cohen, Philip J. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep92, Vol. 99 Issue 3, p331; Subject Term: LANGERHANS cells; Subject Term: ANTIGENS; Subject Term: CELL proliferation; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD proteins; Subject Term: HUMAN cell culture; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12616663
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104736697
T1  - The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation.
AU  - Ren, K
AU  - Hylden, J L
AU  - Williams, G M
AU  - Ruda, M A
AU  - Dubner, R
Y1  - 1992/09//1992 Sep
N1  - Accession Number: 104736697. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Behavior, Animal -- Drug Effects
KW  - Hydrocarbons -- Pharmacodynamics
KW  - Hyperalgesia -- Physiopathology
KW  - Myelitis -- Pathology
KW  - Spinal Cord -- Drug Effects
KW  - Animals
KW  - Electric Stimulation
KW  - Solutions
KW  - Male
KW  - Myelitis -- Chemically Induced
KW  - Myelitis -- Physiopathology
KW  - Neurons -- Drug Effects
KW  - Neurons -- Physiology
KW  - Pain
KW  - Physical Stimulation
KW  - Rats
KW  - Spinal Cord -- Pathology
SP  - 331
EP  - 344
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 50
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1454389.
DO  - 10.1016/0304-3959(92)90039-E
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Anderson, David E.
AU  - Coyle, Kristin
AU  - Haythornthwaite, Jennifer A.
T1  - Ambulatory Monitoring of Respiration: Inhibitory Breathing in the Natural Environment.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1992/09//
VL  - 29
IS  - 5
M3  - Article
SP  - 551
EP  - 557
SN  - 00485772
AB  - Because previous work found that sustained inhibitory breathing (i.e., low frequency breathing without increased tidal volume) can occur in laboratory animals under conditions of behavioral stress, this study sought to determine whether a comparable respiratory pattern could be observed in ambulatory human subjects In their natural environments. Tidal volume, breathing frequency, and minute ventilation were monitored continuously during 24-hour sessions via Inductive plethysmography and a portable microprocessor. Mean tidal volume and minute ventilation were significantly higher during the daytime than at night for all subjects. However, mean breathing frequency was not consistently higher during the daytime, because episodes of low frequency breathing offset episodes of high breathing frequency. Tidal volume during low frequency breathing was comparable to that observed during medium or high frequency breathing. Thus, low frequency breathing was indicative of low minute ventilation. The eliciting stimuli, physiological concomitants, and relevance to health of this energetically inefficient breathing pattern remain to be determined. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESPIRATION
KW  - PLETHYSMOGRAPHY
KW  - LABORATORY animals
KW  - OUTPATIENT medical care
KW  - PSYCHOPHYSIOLOGY
KW  - PERCEPTION
N1  - Accession Number: 11036245; Anderson, David E. 1 Coyle, Kristin 1 Haythornthwaite, Jennifer A. 1; Affiliation:  1: Laboratory of Behavioral Sciences, National Institute on Aging.; Source Info: Sep1992, Vol. 29 Issue 5, p551; Subject Term: RESPIRATION; Subject Term: PLETHYSMOGRAPHY; Subject Term: LABORATORY animals; Subject Term: OUTPATIENT medical care; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: PERCEPTION; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1469-8986.ep11036245
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06464-025
AN  - 2006-06464-025
AU  - Segal, Julius
T1  - Ego, Superego, and Yid: Analyzing the Jew in Freud.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1992/09//
VL  - 37
IS  - 9
SP  - 886
EP  - 886
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06464-025. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Segal, Julius; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Ethnic Identity; Freud (Sigmund); Jews; Psychoanalytic Theory. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Diller, Jerry Victor. Freud's Jewish Identity: A Case Study in the Impact of Ethnicity=Rutherford, NJ: Fairleigh Dickinson University Press/Associated University Presses, 1991. 243 pp. $38.50; 1991. References Available: Y. Page Count: 1. Issue Publication Date: Sep, 1992. 
AB  - Reviews the book, Freud's Jewish Identity: A Case Study in the Impact of Ethnicity by Jerry Victor Diller (1991). Author who describes himself as 'a scholar knowledgeable in issues of minority identity and a student of psychoanalytic history' (p. 24), has written a book that creatively combines these dual threads. The result is a stimulating psychobiography intended to furnish a psychodynamically coherent answer to the often-asked question: How did the Jew in Freud shape his behavior and his products? This volume is a significant addition to the Freud biography shelf. The book deserves a wide audience of readers spanning interests in psychoanalytic theory and practice, Jewish history, and the social psychology of ethnicity. Although Diller's work will not leave all readers convinced that Freud's Jewishness was a major force in his career, it is sure to leave them with a number of robust hypotheses about how the Jew in Freud helped shape his thinking and his products. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychoanalytic history
KW  - psychoanalytic theory
KW  - Freud's Jewishness
KW  - 1992
KW  - Ethnic Identity
KW  - Freud (Sigmund)
KW  - Jews
KW  - Psychoanalytic Theory
KW  - 1992
U2  - Diller, Jerry Victor. (1991); Freud's Jewish Identity: A Case Study in the Impact of Ethnicity; Rutherford, NJ: Fairleigh Dickinson University Press/Associated University Presses, 1991. 243 pp. $38.50; 0-8386-3374-9.
DO  - 10.1037/032559
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Hoak, John C.
AU  - Spector, Arthur A.
T1  - Overview.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/10//
VL  - 56
IS  - 4
M3  - Article
SP  - 783S
EP  - 784S
SN  - 00029165
AB  - The article focuses on the role of dietary fatty acids in causing life-threatening diseases such as myocardial infarction. Topics discussed include atherosclerosis due to alterations in serum lipids and metabolism of lipoproteins, use of fatty acids by liver to synthesize ketone bodies, and association of coronary heart disease and platelet reactivity with intake of saturated fatty acids such as palmitic and stearic acids.
KW  - Lipoproteins
KW  - Fatty acids in human nutrition
KW  - Myocardial infarction
KW  - Atherosclerosis
KW  - Ketone synthesis
KW  - Coronary heart disease
KW  - Palmitic acid
N1  - Accession Number: 94385861; Hoak, John C. 1; Spector, Arthur A. 2; Affiliations: 1: Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; 2: Department of Biochemistry, University of Iowa, Iowa City; Issue Info: Oct1992, Vol. 56 Issue 4, p783S; Thesaurus Term: Lipoproteins; Subject Term: Fatty acids in human nutrition; Subject Term: Myocardial infarction; Subject Term: Atherosclerosis; Subject Term: Ketone synthesis; Subject Term: Coronary heart disease; Subject Term: Palmitic acid; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hoak, John C.
T1  - What is the historical background of research on the role of fatty acids in thrombosis?
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/10//
VL  - 56
IS  - 4
M3  - Article
SP  - 786S
EP  - 786S
SN  - 00029165
AB  - The article discusses the toxic effects of fatty acids in accelerating thrombosis. Topics discussed include derivation of plasma free fatty acids from adipose tissue, injection of unbound, long-chain saturated fatty acids (SFAs) into the systemic circulation of dogs, questions related to the potential thrombogenic effects of dietary SFAs in humans including the development of occlusive vascular lesions, on polyunsaturated fatty acids, and cellular anti-thrombotic system.
KW  - Fatty acids -- Physiological effect
KW  - Thrombosis -- Risk factors
KW  - Free fatty acids
KW  - Adipose tissues
KW  - Saturated fatty acids
KW  - Unsaturated fatty acids
N1  - Accession Number: 94385876; Hoak, John C. 1; Affiliations: 1: Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; Issue Info: Oct1992, Vol. 56 Issue 4, p786S; Subject Term: Fatty acids -- Physiological effect; Subject Term: Thrombosis -- Risk factors; Subject Term: Free fatty acids; Subject Term: Adipose tissues; Subject Term: Saturated fatty acids; Subject Term: Unsaturated fatty acids; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Novak, Melinda A.
AU  - O'Neill, Peggy
AU  - Suomi, Stephen J.
T1  - Adjustments and Adaptations to Indoor and Outdoor Environments: Continuity and Change in Young Adult Rhesus Monkeys.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1992/10//
VL  - 28
IS  - 2
M3  - Article
SP  - 125
EP  - 138
SN  - 02752565
AB  - Optimal environments fur captive primates are assumed to be those which simulate certain ecological features and elicit a wide range of species-typical behavior patterns. Outdoor environments are often thought to be more suitable than indoor environments in that they provide more space and potentially higher levels of stimulation. The purpose of this study was to compare the long-term behavioral responses of several groups of animals that had been reared identically during the first two years of life and then exposed to different environments. Two groups were moved into separate ‘enriched’ indoor pens while one group was moved to an outdoor area covering approximately 5 acres. The monkeys were observed during the first year of life and again in these different environments between the ages of 6 and 10. Although behaviorally similar during the first year of life, monkeys developed different response patterns to indoor and outdoor environments. Contrary to commonly held views, indoor monkeys were not more aggressive, nor did they show higher levels of stereotypical behavior. Instead, indoor monkeys exhibited higher levels of grooming, sexual posturing, tactile/oral exploration, and passive visual behavior than their outdoor counterparts. These differences are consistent with the reconciliation model of de Waal. Individual monkeys also showed remarkable stability in certain traits over the 5-year period. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHESUS monkey
KW  - ANIMAL behavior
KW  - ANIMAL psychology
KW  - ECOLOGY
KW  - MACAQUES
KW  - SEXUAL behavior in animals
KW  - PRIMATES
KW  - STEREOTYPES (Social psychology)
KW  - ANIMALS
KW  - MAMMALS
KW  - behavior
KW  - captive environments
KW  - individual differences
N1  - Accession Number: 12349224; Novak, Melinda A. 1 O'Neill, Peggy 2 Suomi, Stephen J. 2; Affiliation:  1: Department of Psychology, University of Massachusetts, Amherst  2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland; Source Info: 1992, Vol. 28 Issue 2, p125; Subject Term: RHESUS monkey; Subject Term: ANIMAL behavior; Subject Term: ANIMAL psychology; Subject Term: ECOLOGY; Subject Term: MACAQUES; Subject Term: SEXUAL behavior in animals; Subject Term: PRIMATES; Subject Term: STEREOTYPES (Social psychology); Subject Term: ANIMALS; Subject Term: MAMMALS; Author-Supplied Keyword: behavior; Author-Supplied Keyword: captive environments; Author-Supplied Keyword: individual differences; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Malloy, Michael H.
AU  - Hoffman, Howard J.
AU  - Peterson, Donald R.
T1  - Sudden Infant Death Syndrome and Maternal Smoking.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/10//
VL  - 82
IS  - 10
M3  - Article
SP  - 1380
EP  - 1382
PB  - American Public Health Association
SN  - 00900036
AB  - Data from Missouri for the period 1980 to 1985 suggest a dose-response relationship between smoking during pregnancy and the incidence of sudden infant death syndrome (SIDS). However, data from the National Institute of Child Health and Human Development SIDS Co-operative Epidemiological Study did not support a dose-response relationship. Neither the Missouri data nor the Cooperative Study data support a relationship between the age of occurrence of SIDS and smoking during pregnancy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANT women -- Tobacco use
KW  - SUDDEN infant death syndrome
KW  - SMOKING
KW  - INFANTS -- Death
KW  - SYNDROMES in children
KW  - ORAL habits
N1  - Accession Number: 9301313808; Malloy, Michael H. 1,2 Hoffman, Howard J. 1 Peterson, Donald R. 3; Affiliation:  1: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Md.  2: Department of Pediatrics, University of Texas Medical Branch, Galveston  3: Department of Biostatistics, University of Washington, Seattle; Source Info: Oct92, Vol. 82 Issue 10, p1380; Subject Term: PREGNANT women -- Tobacco use; Subject Term: SUDDEN infant death syndrome; Subject Term: SMOKING; Subject Term: INFANTS -- Death; Subject Term: SYNDROMES in children; Subject Term: ORAL habits; Number of Pages: 3p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wells, Barbara L.
AU  - Horm, John W.
T1  - Stage at Diagnosis in Breast Cancer: Race and Socioeconomic Factors.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/10//
VL  - 82
IS  - 10
M3  - Article
SP  - 1383
EP  - 1385
PB  - American Public Health Association
SN  - 00900036
AB  - Cancer incidence data from three US metropolitan areas were coupled with census tract indicators of education and income. The data suggest that both Black and White cancer patients living in census tracts with lower median education/income values are diagnosed in later disease stages than are patients in tracts with higher median education/income values. Within education and income strata, Black women had a less favorable stage of disease at diagnosis than Whites. The exception was in upper education/income levels, where the disadvantage for Blacks disappeared. These data provide additional evidence that women of low socioeconomic status could benefit from targeted screening. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER patients
KW  - EDUCATION
KW  - INCOME
KW  - SOCIAL status
KW  - METROPOLITAN areas
KW  - UNITED States
N1  - Accession Number: 9301313809; Wells, Barbara L. 1 Horm, John W. 2; Affiliation:  1: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD.  2: Division of Health Interview Statistics, National Center for Health Statistics, Hyattsville, Md.; Source Info: Oct92, Vol. 82 Issue 10, p1383; Subject Term: CANCER patients; Subject Term: EDUCATION; Subject Term: INCOME; Subject Term: SOCIAL status; Subject Term: METROPOLITAN areas; Subject Term: UNITED States; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 3p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107495140
T1  - The premenstrual syndrome. New views.
AU  - Rubinow DR
AU  - Rubinow, D R
Y1  - 1992/10/14/
N1  - Accession Number: 107495140. Language: English. Entry Date: 19921201. Revision Date: 20161112. Publication Type: journal article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Premenstrual Syndrome -- Etiology
KW  - Premenstrual Syndrome -- Diagnosis
KW  - Endocrine System
KW  - Sex Hormones
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Female
SP  - 1908
EP  - 1912
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 268
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Section on Behavioral Endocrinology, National Institute of Mental Health, Bethesda, Md. 20892
AD  - Office Clinical Director, Natl Inst Mental Health, Bldg 10, Room 3N238, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 1404717.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rosa, Patricia A.
AU  - Schwan, Tom
AU  - Hogan, Daniel
T1  - Recombination between genes encoding major outer surface proteins A and B of <em>Borrelia burgdorferi</em>.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992/10/15/
VL  - 6
IS  - 20
M3  - Article
SP  - 3031
EP  - 3040
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Borrelia burgdorferi causes Lyme disease, a multisystem illness that can persist in humans for many years. We describe recombination between homologous genes encoding the major outer surface proteins (Osps) A and B of B. burgdorferi which both deletes osp gene sequences and creates chimaeric gene fusions. Recombinant osp genes occur in multiple strains and encode unique proteins that lack some characteristic Osp epitopes. Antigenic variation in Osp through recombination may be relevant to the persistence of B. burgdorferi in an infected host, and has important implications for the utility of OspA and OspB as diagnostic or vaccine candidates for Lyme disease. We also describe Osp variation arising from nonsense mutations and sequence divergence, which may also represent significant sources of Osp polymorphism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutation (Biology)
KW  - Borrelia burgdorferi
KW  - Lyme disease
KW  - Genes
KW  - Proteins
N1  - Accession Number: 15899279; Rosa, Patricia A. 1; Schwan, Tom 2; Hogan, Daniel 1; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Hamilton, Montana 59840, USA; 2: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; Issue Info: Oct1992, Vol. 6 Issue 20, p3031; Thesaurus Term: Mutation (Biology); Subject Term: Borrelia burgdorferi; Subject Term: Lyme disease; Subject Term: Genes; Subject Term: Proteins; Number of Pages: 10p; Illustrations: 7 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Seuanez, H.N.
AU  - Alves, G.
AU  - Lima, M.M.C.
AU  - Barros, R. de Souza
AU  - Barroso, C.M.L.
AU  - Muniz, J.A.P.C.
T1  - Chromosome Studies in Chiropotes satanas utahicki Hershkovits, 1985 (Cebidae, Platyrrhini): A Comparison With Chiropotes satanas chiropotes.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1992/11//
VL  - 28
IS  - 3
M3  - Article
SP  - 213
EP  - 222
SN  - 02752565
AB  - Karyological characterization of C.s. utahicki (2n = 54) and C.s. chiropotes (2n = 54) showed that these two subspecies are chromosomally very similar. In a single, isolated specimen of C.s. utahicki, however, a derived, biarmed, chromosome 14 was found in the heterozygous condition. This variant chromosome was identical with pair 10 in C.s. chiropotes in which this chromosome type was apparently fixed. Chromosome differences between these subspecies might be transitional, leading to the establishment of two different karyomorphic populations derived from a once uniform karyotypic group that split into separate allopatric subspecies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHROMOSOMES
KW  - CEBIDAE
KW  - KARYOTYPES
KW  - FUNGUS weevils
KW  - PRIMATES
KW  - SPECIES
KW  - Chiropotes
KW  - satanas
KW  - subspecies
N1  - Accession Number: 12349572; Seuanez, H.N. 1 Alves, G. 2 Lima, M.M.C. 3 Barros, R. de Souza 3 Barroso, C.M.L. 3 Muniz, J.A.P.C. 4; Affiliation:  1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center  2: Servico de Genetica, Instituto Nacional do Cancer, Rio de Janeiro  3: Departamento de Genetica, Universidade Federal do Para  4: Centro Nacional de Primatas; Source Info: 1992, Vol. 28 Issue 3, p213; Subject Term: CHROMOSOMES; Subject Term: CEBIDAE; Subject Term: KARYOTYPES; Subject Term: FUNGUS weevils; Subject Term: PRIMATES; Subject Term: SPECIES; Author-Supplied Keyword: Chiropotes; Author-Supplied Keyword: satanas; Author-Supplied Keyword: subspecies; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Biggar, Robert J.
AU  - Melbye, Mads
T1  - Responses to Anonymous Questionnaires Concerning Sexual Behavior: A Method to Examine Potential Biases.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/11//
VL  - 82
IS  - 11
M3  - Article
SP  - 1506
EP  - 1512
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Low response rates to voluntary surveys raise questions about how representative the responses are. We compared the behavior and attitudes of responders, willing and reluctant, and nonresponders to anonymous questionnaires about behaviors that might expose participants to the human immunodeficiency virus (HIV). Methods. Questionnaires were sent to 1080 Danish adults 18 through 59 years including explicit questions about sexual acts and illegal drug use. Identical questionnaires were sent to 3600 other Danes, similarly chosen; packets sent to these persons included cards to be returned separately informing us that they had responded. Questionnaires were sent twice more to nonresponders who, if they then responded, were considered reluctant responders. One hundred nonresponders were telephoned and asked why they had refused to respond. Results. Enclosing return cards did not affect initial response rate, but prompting boosted replies from 52% to 73%. However, behaviors were generally similar among initial and reluctant responders. One third of nonresponders agreed to respond if we wished (total potential response: 82%). In general, the reasons for nonresponse did not suggest that the life-styles of nonresponders placed them at risk for HIV infection. Conclusions. This method provides a simple, inexpensive approach to improving response rates and learning about the biases of reluctant responders and nonresponders.  INSET: Infectious diseases update for the primary care physician.. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESPONSE rates
KW  - HEALTH surveys
KW  - ATTITUDE (Psychology)
KW  - SEXUAL intercourse
KW  - DRUG abuse
KW  - DENMARK
N1  - Accession Number: 9302211652; Biggar, Robert J. 1 Melbye, Mads 2; Affiliation:  1: Viral Epidemiology Section, National Cancer Institute, Bethesda, Md.  2: Department of Epidemiology, State Serum Institute, Copenhagen, Denmark; Source Info: Nov92, Vol. 82 Issue 11, p1506; Subject Term: RESPONSE rates; Subject Term: HEALTH surveys; Subject Term: ATTITUDE (Psychology); Subject Term: SEXUAL intercourse; Subject Term: DRUG abuse; Subject Term: DENMARK; Number of Pages: 7p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brownson, Ross C.
AU  - Alavanja, Michael C. R.
AU  - Hock, Edward T.
AU  - Loy, Timothy S.
T1  - Passive Smoking and Lung Cancer in Nonsmoking Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/11//
VL  - 82
IS  - 11
M3  - Article
SP  - 1525
EP  - 1530
PB  - American Public Health Association
SN  - 00900036
AB  - The causes of lung cancer among nonsmokers are not clearly understood. To further evaluate the relation between passive smoke exposure and lung cancer in nonsmokers women, we conducted a population-based, case-control study. Methods. Case patients (n = 618), identified through the Missouri Cancer Registry for the period 1986 through 1991, included 432 life-time nonsmokers and 186 ex-smokers who had stopped at least 15 years before diagnosis or who had smoked for less than 1 pack-years. Control subjects (n = 1402) were selected from driver's license and Medicare Results. No increased risk of lung cancer was associated with childhood passive smoke exposure. Adulthood analyses showed an increased lung cancer risk for lifetime nonsmokers with exposure of more than 40 pack-years from all houses-hold members (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 1.0, 1.8) or from spouses only (OR = 1.3; 95% CI = 1.0, 1.7). When the times weighted product of pack-years and average hours exposed per day was considered, a 30% excess risk was shown at the highest quartile of exposure among lifetime nonsmokers. Conclusions. Ours and other recent studies suggest a small but consistent increased risk of lung cancer from passive smoking. Comprehensive actions to limit smoking in public places and worksites are well-advised. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PASSIVE smoking
KW  - LUNGS -- Cancer
KW  - WOMEN -- Diseases
KW  - WOMEN -- Health
KW  - CANCER -- Risk factors
KW  - MISSOURI
N1  - Accession Number: 9302211655; Brownson, Ross C. 1 Alavanja, Michael C. R. 2 Hock, Edward T. 3 Loy, Timothy S. 4; Affiliation:  1: Division of Chronic Disease Prevention and Health Promotion, Missouri Department of Health, Columbia, Mo.  2: Epidemiology and Biostatistics Program, National Cancer Institute, Rockville, Md.  3: Information Member Services, Rockville, Md.  4: Pathology Department, University of Missouri School of Medicine, Columbia, Mo.; Source Info: Nov92, Vol. 82 Issue 11, p1525; Subject Term: PASSIVE smoking; Subject Term: LUNGS -- Cancer; Subject Term: WOMEN -- Diseases; Subject Term: WOMEN -- Health; Subject Term: CANCER -- Risk factors; Subject Term: MISSOURI; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoover, Donald R.
AU  - Saah, Alfred
AU  - Bacellar, Helena
AU  - Murphy, Robert
AU  - Visscher, Barbara
AU  - Metz, Sharon
AU  - Anderson, Roger
AU  - Kaslow, Richard A.
T1  - The Progression of Untreated HIV-1 Infection Prior to AIDS.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/11//
VL  - 82
IS  - 11
M3  - Article
SP  - 1538
EP  - 1541
PB  - American Public Health Association
SN  - 00900036
AB  - Using a case-control study of untreated men, we investigated the physical, mental, and economic effects of human immunodeficiency virus (HIV-1) infection prior to the diagnosis of acquired immunodeficiency syndrome (AIDS). Beginning 2 to 2.5 years prior to AIDS, case subjects reported more of 12 HIV-1 related symptoms and during the year prior to AIDS, at least 30.6 extra days of these symptoms than did control subjects. Within the 6 months preceding AIDS, case subjects' unemployment rose to 9% (p ≤ .05) and depression to 34.2% (P≤ .001). At 6 to 12 months and within 6 months before AIDS, 17.1% and 31.5%, respectively, were anemic, while 37.7% and 64.7% had CD4+ counts less than 200 × 106/L. Diagnosing AIDS at CD4+ counts less than 200 × 106/L could significantly reduce pre-AIDS morbidity. Other implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV infections
KW  - HIV-positive men
KW  - AIDS (Disease)
KW  - SYMPTOMS
KW  - DIAGNOSIS
N1  - Accession Number: 9302211659; Hoover, Donald R. 1 Saah, Alfred 1 Bacellar, Helena 1 Murphy, Robert 2 Visscher, Barbara 3 Metz, Sharon 1 Anderson, Roger 4 Kaslow, Richard A. 5; Affiliation:  1: School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md.  2: Division of Infectious Diseases, Northwestern University Medical School, Evanston, Ill.  3: School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles.  4: Graduate School of Public Health, University of Pittsburgh, Pa.  5: National Institute of Allergy and Infectious Diseases, National institutes of Health, Bethesda, Md.; Source Info: Nov92, Vol. 82 Issue 11, p1538; Subject Term: HIV infections; Subject Term: HIV-positive men; Subject Term: AIDS (Disease); Subject Term: SYMPTOMS; Subject Term: DIAGNOSIS; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thompson, H. L.
AU  - Matushima, K.
T1  - Human polymorphonuclear leucocytes stimulated by tumour necrosis factor-alpha show increased adherence to extracellular matrix proteins which is mediated via the CD11b/18 complex.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1992/11//
VL  - 90
IS  - 2
M3  - Article
SP  - 280
EP  - 285
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The present study demonstrates that tumour necrosis factor (TNF) and FMLP, but not IL-1 or IL-8, enhanced the adherence of polymorphonuclear neutrophil (PMN) lo fibronectin. an extracellular matrix protein. The adherence induced by FMLP was very rapid, within 5 min white the induction of adherence by TNF was much slower, reaching maximum at 60 min. TNF also enhanced an adhesion of PMN lo other extracellular matrix proteins, such as laminin, collagen IV and gelatin 11, but not to human serum albumin. Anti-CD18 MoAb completely inhibited the binding of TNF-stimulated PMN lo fibronectin and partially inhibited the binding to laminin. Further investigation showed that adhesion of TNF-stimulated PMN to fibronectin and laminin was inhibited by anti-CDllb MoAb and lo a lesser extent by CDlla MoAb. In contrast lo TNF-stimulated PMN the binding of unstimulated PMN to fibronectin and laminin was only inhibited by anti-CDlla MoAb. Anti- CD11c had no effect on PMN adherence. These results suggest that unstimulated PMN adhere to extracellular proteins through the CD1la/18, while TNF-stimulated PMN adhere through the CDllb/18. These results suggest that TNF secreted at the site of inflammation may enhance the interaction of PMN with the extravascular environment through the CD1lb 18 complex. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXTRACELLULAR matrix proteins
KW  - NEUTROPHILS
KW  - TUMOR necrosis factor
KW  - BLOOD cells
KW  - SERUM albumin
KW  - BLOOD plasma
KW  - adhesion
KW  - integrins
KW  - polymorphonuclear leucocytes
KW  - tumour necrosis factor
N1  - Accession Number: 16024827; Thompson, H. L. 1 Matushima, K. 2; Affiliation:  1: Cytokine Biochemistry, Strangeways Research Laboratory, Cambridge, UK.  2: Biological Response Modifiers Prog., Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick Cancer Research & Development Center, Frederick, USA.; Source Info: Nov1992, Vol. 90 Issue 2, p280; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: NEUTROPHILS; Subject Term: TUMOR necrosis factor; Subject Term: BLOOD cells; Subject Term: SERUM albumin; Subject Term: BLOOD plasma; Author-Supplied Keyword: adhesion; Author-Supplied Keyword: integrins; Author-Supplied Keyword: polymorphonuclear leucocytes; Author-Supplied Keyword: tumour necrosis factor; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chopra, R. K.
AU  - Carroll, M. P.
AU  - May, W. S.
AU  - Bhatia, S. K.
AU  - Margolick, J. B.
AU  - Nagel, J. E.
AU  - Adler, W. H.
T1  - Four interleukin-2 surface binding proteins detected in rat spleen cells.
JO  - Immunology
JF  - Immunology
Y1  - 1992/11//
VL  - 77
IS  - 3
M3  - Article
SP  - 338
EP  - 344
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Four specific interleukin-2 (IL-2) surface binding proteins can be detected by covalent cross-linking of [125I]IL-2 to rat spleen cells that have been activated with various stimuli including concanavalin A (Con A), phytohaemagglutinin (PHA), calcium ionophore, and phorbol dibutyrate (PDB) with or without calcium ionophore. These four cross-linked proteins could not be demonstrated in either unstimulated T cells or in activated T cells when binding was performed in the presence of a 20-100- fold excess of unlabelled IL-2. The molecular weights of the four cross-linked proteins, after subtraction of the molecular weight contribution of IL-2 are: 53,000,70,000,90,000 and 118,000. The 53,000 MW protein was identified as the rat 11-2 receptor (IL-2R) 2-chain by immune precipitation. Additionally, results suggest that the rat LL-2R α-chain is tightly complexed to both the 118,000 and 90,000 MW IL-2 binding proteins. Purification of surface labelled proteins from activated cells using IL-2 affinity chromatography yields four proteins with similar molecular weight to those identified by cross-linking plus an additional non-ligand cross-linked protein of 46,000 MW. The 46,000 MW band may be a non-binding associated protein since it was not seen following [125I]IL-2 binding cross- linking. Tryptic digests and two-dimensional separation of the affinity-isolated proteins indicate that unique peptide maps are generated for the 46,000. 53,000 and 70,000 MW proteins and excludes the possibility that the bands identified by cross-linking represents cross-linking of multiple ligands to the 53,000 MW subunit. However, the 90,000 and 118,000 MW bands yield peptide maps that closely resemble each other suggesting that these binding proteins may be related. These results suggest that at least four IL-2 surface binding proteins may constitute the rat IL-2R system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - CARRIER proteins
KW  - CELLS
KW  - PHORBOLS
KW  - CELL receptors
KW  - PEPTIDES
N1  - Accession Number: 14079185; Chopra, R. K. 1 Carroll, M. P. 2 May, W. S. 2 Bhatia, S. K. 3 Margolick, J. B. 1 Nagel, J. E. 4 Adler, W. H. 4; Affiliation:  1: Department of Environmental Health Sciences, Baltimore, Maryland, U.S.A.  2: Department of Immunology and Infectious Diseases, School of Hygiene and Public Health, Baltimore, Maryland, U.S.A.  3: Oncology Center, Johns Hopkins University, Baltimore, Maryland, U.S.A.  4: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, U.S.A.; Source Info: Nov92, Vol. 77 Issue 3, p338; Subject Term: INTERLEUKIN-2; Subject Term: CARRIER proteins; Subject Term: CELLS; Subject Term: PHORBOLS; Subject Term: CELL receptors; Subject Term: PEPTIDES; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Geracioti Jr., Thomas D.
AU  - Gold, Philip W.
T1  - Oscillatory Instability of Body Weight in Alternating Anorexia Nervosa and Bulimia Nervosa.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1992/11//
VL  - 12
IS  - 3
M3  - Article
SP  - 301
EP  - 306
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - The present study was undertaken to clarify the longitudinal course, from adolescence to the age of 40, of weight fluctuations in a woman with alternating anorexia nervosa and bulimia nervosa. Although it has long been appreciated that a single person may fluctuate between states of binge eating and obesity on the one hand, and starvation on the other, few data exist regarding the nature and mechanism of this interrelationship. As opposed to the gradual linear increase in weight normally observed in human beings from early adulthood through middle age, our patient with alternating bulimia nervosa and anorexia nervosa showed chronic weight oscillation of great magnitude. However, her weight oscillations were periodic, as opposed to chaotic, and oscillated around her ideal body weight of 137 pounds. Moreover, the frequency of major weight changes increased with lime. It is possible that a fundamental dysregulation of the hypothalamic feeding apparatus, wherein the normal homeostatic system loses its stability so that periodic oscillatory behavior results, unites the syndromes of anorexia and bulimia nervosa in the same individual. Finally, the pathological weight dynamics observed in this case show similarities to the phenomenology and course of bipolar affective disorders. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BODY weight
KW  - ANOREXIA nervosa
KW  - BULIMIA
KW  - COMPULSIVE eating
KW  - EATING disorders
KW  - OBESITY
KW  - WOMEN -- Diseases
KW  - FOOD consumption
KW  - HUMAN body composition
N1  - Accession Number: 11918459; Geracioti Jr., Thomas D. 1 Gold, Philip W. 2; Affiliation:  1: Assistant Professor of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37232  2: Chief, Clinical Neuroendocrinology Branch, National Institute of Mental Health, Nashville, TN 37232; Source Info: Nov1992, Vol. 12 Issue 3, p301; Subject Term: BODY weight; Subject Term: ANOREXIA nervosa; Subject Term: BULIMIA; Subject Term: COMPULSIVE eating; Subject Term: EATING disorders; Subject Term: OBESITY; Subject Term: WOMEN -- Diseases; Subject Term: FOOD consumption; Subject Term: HUMAN body composition; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rieger, Armin
AU  - Binghe Wang
AU  - Kilgus, Oliver
AU  - Ochiai, Kenichi
AU  - Maurer, Dieter
AU  - Födinger, Dagmar
AU  - Kinet, Jean-Pierre
AU  - Stingl, Georg
T1  - Fc∈RI Mediates IgE Binding to Human Epidermal Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/11//
VL  - 99
IS  - 5
M3  - Article
SP  - 30S
EP  - 32S
SN  - 0022202X
AB  - In a recent series of experiments, we observed that epidermal Langerhans cells (LC) of healthy, non-atopic individuals have the capacity of specifically binding monomeric serum or myeloma IgE. IgE-binding to LC could neither be prevented by pre-incubation of the cryostat sections with monoclonal antibodies (MoAb) against either Fc∈RII/CD23 or FcγRII/ CD32 nor by the addition of excess amounts of lactose, but could be entirely abrogated by pre-incubation with the antiFc∈RI MoAb 15-1. A direct testing of the anti-Fc∈;RI MoAb 15-1 and 19-1 on cryostat sections in an indirect immunodouble-labeling technique showed that, in contrast to eight different anti-Fc∈RII/CD23 MoAb, these MoAb react with the majority of CD1a-bearing epidermal cells. At an ultrastructural level, 15-1 immunogold-labeling in the epidermis was confined to the surface of cells exhibiting Birbeck granules. In further experiments, we were able to amplify by polymerase chain reaction (PCR) technology transcripts for the α, β, and γ chains of Fc∈RI from LC-enriched epidermal cells and dermal cells, but not from LC-depleted epidermal cells. Transcripts for the mast cell enzyme tryptase were exclusively found in dermal cell-derived RNA preparations, thus excluding a contamination of the LC-enriched epidermal cell preparations by dermal mast cells. Collectively, these data show that epidermal LC, but no other epidermal cells, express Fc∈RI molecules. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - MONOCLONAL antibodies
KW  - IMMUNOGLOBULINS
KW  - MOLECULAR cloning
KW  - IMMUNOGLOBULIN E
KW  - POLYMERASE chain reaction
N1  - Accession Number: 12668293; Rieger, Armin 1 Binghe Wang 1 Kilgus, Oliver 1 Ochiai, Kenichi 2 Maurer, Dieter 1 Födinger, Dagmar 1 Kinet, Jean-Pierre 2 Stingl, Georg 1; Affiliation:  1: Department of Dermatology I, Division of Cutaneous Immunobiology, University of Vienna Medical School, Vienna, Austria  2: Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, U.S.A.; Source Info: Nov92, Vol. 99 Issue 5, p30S; Subject Term: LANGERHANS cells; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: MOLECULAR cloning; Subject Term: IMMUNOGLOBULIN E; Subject Term: POLYMERASE chain reaction; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12668293
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Enk, Alexander H.
AU  - Katz, Stephen I.
T1  - Early Events in the Induction Phase of Contact Sensitivity.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/11//
VL  - 99
IS  - 5
M3  - Article
SP  - 39S
EP  - 41S
SN  - 0022202X
AB  - After allergen application to skin, there is enhanced class II major histocompatibility complex antigen expression, as well as enhanced T-cell- stimulatory function by epidermal Langerhans cells (LC). In this study, we investigated the early changes in the epidermal cytokine profile using a sensitive reverse transcriptase PCR technique to determine whether cytokines may be related to LC activation. We found that, on the mRNA and protein level, changes in the epidermal cytokine pattern caused by allergens in the induction phase of contact sensitivity are distinct from those caused by irritants or tolerogens. The earliest of the changes is the LC-derived interleukin (IL) lβ mRNA signal strength that is increased within 15 min of allergen painting. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALLERGENS
KW  - MAJOR histocompatibility complex
KW  - IMMUNOGENETICS
KW  - T cells
KW  - LANGERHANS cells
KW  - DENDRITIC cells
N1  - Accession Number: 12668608; Enk, Alexander H. 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Nov92, Vol. 99 Issue 5, p39S; Subject Term: ALLERGENS; Subject Term: MAJOR histocompatibility complex; Subject Term: IMMUNOGENETICS; Subject Term: T cells; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12668608
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Aimin Tang
AU  - Udey, Mark C.
T1  - Doses of Ultraviolet Radiation that Modulate Accessory Cell Activity and ICAM-1 Expression Are Ultimately Cytotoxic for Murine Epidermal Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/11//
VL  - 99
IS  - 5
M3  - Article
SP  - 71S
EP  - 73S
SN  - 0022202X
AB  - Mechanisms that underlie immunomodulatory properties of ultraviolet (UV) radiation remain incompletely characterized. Recently, we have studied effects of-UV on the functional activity of epidermal Langerhans cells (LC) and have attempted to relate inhibitory effects of UV on LC function to modulatory effects of UV on adhesion molecule expression by LC. Exposure of LC in vitro to amounts of UVB, UVC, or psoralen + UVA (PUVA) radiation that inhibited LC function also prevented increased expression of intercellular adhesion molecule-1 by LC in vitro. Subsequent studies revealed that amounts of UV radiation that inhibited LC function and modulated ICAM-1 expression also decreased LC survival in vitro, although UV-induced LC cytotoxicity did not become apparent until 48-72 h after UV exposure. Our results are consistent with those of previous studies that suggested that low doses of UV radiation were cytotoxic for LC in situ. The potential cytotoxicity of UV radiation for LC should be considered when studies of effects of UV radiation on immune responses in skin are interpreted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRAVIOLET radiation
KW  - LANGERHANS cells
KW  - DENDRITIC cells
KW  - EPIDERMIS
KW  - CELL adhesion molecules
KW  - BIOMOLECULES
N1  - Accession Number: 12669789; Aimin Tang 1 Udey, Mark C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov92, Vol. 99 Issue 5, p71S; Subject Term: ULTRAVIOLET radiation; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS; Subject Term: CELL adhesion molecules; Subject Term: BIOMOLECULES; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12669789
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Francis, C. L.
AU  - Starnbach, M. N.
AU  - Falkow, S.
T1  - Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low-oxygen conditions.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992/11//
VL  - 6
IS  - 21
M3  - Article
SP  - 3077
EP  - 3087
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - <em>Salmonella typhimurium</em> grown under oxygen-limiting conditions were found to enter into, elicit actin filament rearrangement in, and effect morphological changes upon HEp-2 cells within 15 min after infection. Video microscopy revealed that host cell morphological changes associated with entry began within 1 min of productive adherence. Polarized Caco-2 cell morphology was affected 40 s after Infection with low-oxygen-grown <em>S. typhimurium</em>. Stationary-phase <em>S. typhimurium</em> did not elicit these phenomena within this time-period even when adherence was enhanced with the afimbrial adhesin, AFA-I. Thus, environmental cues regulate <em>S. typhimurium</em> invasion factors, allowing for immediate entry into host cells. Additionally, actin filament rearrangement and morphological changes in the eukaryotic host cell are essential for entry and occur within minutes of infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cell adhesion
KW  - Salmonella typhimurium
KW  - Actin
KW  - Cellular growth
KW  - Morphogenesis
N1  - Accession Number: 16598380; Francis, C. L. 1; Starnbach, M. N. 1; Falkow, S. 1,2; Affiliations: 1: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA; 2: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; Issue Info: Nov1992, Vol. 6 Issue 21, p3077; Thesaurus Term: Cell adhesion; Subject Term: Salmonella typhimurium; Subject Term: Actin; Subject Term: Cellular growth; Subject Term: Morphogenesis; Number of Pages: 11p; Illustrations: 6 Black and White Photographs, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pillar, Barbara
T1  - Bioethical Issues in the Use of Technology.
JO  - Nursing Economic$
JF  - Nursing Economic$
Y1  - 1992/11//Nov/Dec92
VL  - 10
IS  - 6
M3  - Article
SP  - 419
EP  - 422
PB  - Jannetti Publications, Inc.
SN  - 07461739
AB  - Bioethics is the application of ethical analysis to issues of health care. The guiding body of ethical principles remains the same whether one is discussing the lack of access in rural health care, the right to die, or use of total parenteral nutrition for persons with AIDS. Bioethical decision making is supported first by the basic principles of ethics and the methods of philosophic inquiry and research. The analysis of bioethical issues in the use of health care technology can be accomplished with the same processes of evaluation and judgment as other social or health care issues.
KW  - BIOETHICS
KW  - MEDICAL care
KW  - PUBLIC health
KW  - RURAL health
KW  - MEDICAL technology
KW  - AIDS patients
N1  - Accession Number: 12241116; Pillar, Barbara 1; Affiliation:  1: National Center for Nursing Research, National Institutes of Health, Bethesda, MD.; Source Info: Nov/Dec92, Vol. 10 Issue 6, p419; Subject Term: BIOETHICS; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: RURAL health; Subject Term: MEDICAL technology; Subject Term: AIDS patients; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hall, Nicholas G.
AU  - Hershey, John C.
AU  - Kessler, Larry G.
AU  - Craig Stotts, R.
T1  - A MODEL FOR MAKING PROJECT FUNDING DECISIONS AT THE NATIONAL CANCER INSTITUTE.
JO  - Operations Research
JF  - Operations Research
Y1  - 1992/11//Nov/Dec92
VL  - 40
IS  - 6
M3  - Article
SP  - 1040
PB  - INFORMS: Institute for Operations Research
SN  - 0030364X
AB  - This paper describes the development of a model for making project funding decisions at The National Cancer Institute (NCI). The American Stop Smoking Intervention Study (ASSIST) is a multiple-year, multiple-site demonstration project, aimed at reducing smoking prevalence. The initial request for ASSIST proposals was answered by about twice as many states as could be funded. Scientific peer review of the proposals was the primary criterion used for funding decisions. However, a modified Delphi process made explicit several criteria of secondary importance. A structured questionnaire identified the relative importance of these secondary criteria, some of which we incorporated into a composite preference function. We modeled the proposal funding decision as a zero-one program, and adjusted the preference function and available budget parametrically to generate many suitable outcomes. The actual funding decision, identified by our model, offers significant advantages over manually generated solutions found by experts at NCI. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Operations Research is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH institutes
KW  - RESEARCH -- Finance
KW  - OPERATIONS research
KW  - DECISION making
KW  - SMOKING -- Prevention
KW  - SMOKING
KW  - CANCER
KW  - UNITED States
KW  - NATIONAL Cancer Institute (U.S.)
N1  - Accession Number: 4495280; Hall, Nicholas G. 1; Hershey, John C. 2; Kessler, Larry G. 3; Craig Stotts, R. 3; Affiliations: 1: Ohio State University, Columbus, Ohio.; 2: University of Pennsylvania, Philadelphia, Pennsylvania.; 3: National Cancer Institute, Bethesda, Maryland.; Issue Info: Nov/Dec92, Vol. 40 Issue 6, p1040; Thesaurus Term: RESEARCH institutes; Thesaurus Term: RESEARCH -- Finance; Thesaurus Term: OPERATIONS research; Thesaurus Term: DECISION making; Subject Term: SMOKING -- Prevention; Subject Term: SMOKING; Subject Term: CANCER; Subject: UNITED States ; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
T1  - Suppression of Incessant Ventricular Tachycardia in Hypertrophic Cardiomyopathy Associated with Improvement of Severe Left Ventricular Dysfunction.
AU  - McAreavey, Dorothea
AU  - Eananapazir, Lameh
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
Y1  - 1992/11//
VL  - 15
IS  - 11P1
SP  - 1642
EP  - 1645
SN  - 01478389
N1  - Accession Number: 17478432; Author: McAreavey, Dorothea: 1 Author: Eananapazir, Lameh: 1 ; Author Affiliation: 1 Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.; No. of Pages: 4; Language: English; Publication Type: Article; Update Code: 20050630
N2  - A 32-year-old black man presented with a history of palpitations since childhood and two syncopal episodes. He was found to have incessant ventricular tachycardia, impaired left ventricular contraction (ejection fraction 9%), and nonobstructive hypertrophic cardiomyopathy. Procainamide abolished the arrhythmia and the ejection fraction rose to 22% in sinus rhythm. Later treatment was switched to amiodarone, which suppressed the ventricular tachycardia but necessitated pacemaker implantation. He has remained well during the subsequent 2 years. Left ventricular ejection fraction has increased to 47% measured in paced rhythm. The improvement in left ventricular function has been attributed to suppression of the incessant ventricular tachycardia. ABSTRACT FROM AUTHOR
KW  - *TACHYCARDIA
KW  - *ARRHYTHMIA
KW  - *HEART beat
KW  - *HYPERTROPHIC cardiomyopathy
KW  - *KETONES
KW  - AMIODARONE
KW  - hypertrophic cardiomyopathy
KW  - incessant ventricular tachycardia
KW  - left ventricular dysfunction
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 104733982
T1  - Demonstration of dynorphin A 1-8 immunoreactive axons contacting spinal cord projection neurons in a rat model of peripheral inflammation and hyperalgesia.
AU  - Nahin, R L
AU  - Hylden, J L
AU  - Humphrey, E
Y1  - 1992/11//1992 Nov
N1  - Accession Number: 104733982. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Nerve Fibers -- Metabolism
KW  - Opioid Peptides -- Metabolism
KW  - Inflammation -- Pathology
KW  - Nerve Endings -- Physiology
KW  - Neurons -- Metabolism
KW  - Pain -- Pathology
KW  - Peptides -- Metabolism
KW  - Peripheral Nerves -- Pathology
KW  - Spinal Cord -- Metabolism
KW  - Animals
KW  - Nerve Fibers -- Immunology
KW  - Neurons -- Physiology
KW  - Opioid Peptides -- Immunology
KW  - Immunohistochemistry
KW  - Male
KW  - Peptides -- Immunology
KW  - Peripheral Nerves -- Immunology
KW  - Rats
KW  - Receptors, Cell Surface -- Immunology
KW  - Receptors, Cell Surface -- Metabolism
KW  - Spinal Cord
SP  - 135
EP  - 143
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 51
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1362457.
DO  - 10.1016/0304-3959(92)90254-9
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104737960
T1  - Painful neuropathy: altered central processing maintained dynamically by peripheral input.
AU  - Gracely, R H
AU  - Lynch, S A
AU  - Bennett, G J
Y1  - 1992/11//1992 Nov
N1  - Accession Number: 104737960. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Pain -- Physiopathology
KW  - Peripheral Nerves -- Physiopathology
KW  - Reflex Sympathetic Dystrophy -- Physiopathology
KW  - Adult
KW  - Anesthesia
KW  - Anesthetics, Local -- Pharmacodynamics
KW  - Cold
KW  - Female
KW  - Heat
KW  - Male
KW  - Mechanoreceptors -- Physiology
KW  - Middle Age
KW  - Nerve Block
KW  - Nerve Fibers -- Physiology
KW  - Neurons, Afferent -- Drug Effects
KW  - Neurons, Afferent -- Physiology
KW  - Pain Measurement
KW  - Skin Temperature -- Physiology
SP  - 175
EP  - 194
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 51
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 1484715.
DO  - 10.1016/0304-3959(92)90259-E
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - CASE
AU  - Sharara, Fady I.
AU  - Chrousos, George P.
AU  - Patronas, Nicholas J.
T1  - Watchful Waiting and Craniopharyngioma.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1992/11/15/
VL  - 117
IS  - 10
M3  - Case Study
SP  - 876
EP  - 877
SN  - 00034819
AB  - The article presents a case study of a 35-year-old woman diagnosed with craniopharyngioma. It states the patient started having mild, frontal headaches and sinus complaints in 1985 and that radiography revealed an enlarged sella turcica. It mentions the patient chose against radiotherapy or neurologic surgery and has not had a change in symptoms for over six years. It comments on complications associated with radiotherapy and surgery of craniopharyngioma.
KW  - CRANIOPHARYNGIOMA
KW  - MEDICAL radiography
KW  - SELLA turcica
KW  - SYMPTOMS
KW  - RADIOTHERAPY
KW  - SURGERY
N1  - Accession Number: 99626205; Sharara, Fady I. 1 Chrousos, George P. 1 Patronas, Nicholas J. 1; Affiliation:  1: National Institutes of Health, Bethesda, MD 20892; Source Info: 11/15/92, Vol. 117 Issue 10, p876; Subject Term: CRANIOPHARYNGIOMA; Subject Term: MEDICAL radiography; Subject Term: SELLA turcica; Subject Term: SYMPTOMS; Subject Term: RADIOTHERAPY; Subject Term: SURGERY; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 2p; Document Type: Case Study
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zaharevitz, Daniel W.
AU  - Anderson, Lawrence W.
AU  - Malinowski, Nancy M.
AU  - Hyman, Roosevelt
AU  - Strong, John M.
AU  - Cysyk, Richard L.
T1  - Contribution of <em>de-novo</em> and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors <em>in vivo</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1992/11/15/
VL  - 210
IS  - 1
M3  - Article
SP  - 293
EP  - 296
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The relative contribution of de-novo and salvage synthesis to tissue pyrimidine nucleotide pools is an important parameter in the rational design of anti-pyrimidine therapies, but has not been measured in vivo. We have measured the contribution of de-novo synthesis to the total acid-soluble uracil nucleotide pool in mouse tissues by analysis of the incorporation of label after intra-peritoneal infusion of L-[15N]alanine. The contribution of salvage synthesis was measured by the incorporation of radiolabel after intravenous infusion of [14C]uridine. The results show that de-novo synthesis makes the larger contribution to the intestine uracil nucleotide pool, salvage synthesis makes the larger contribution to the kidney pool, and de-novo and salvage synthesis make roughly equal contributions to the liver pool. In tumors studied (L1210, P388, B16, Nettesheim), the contribution of de-novo synthesis was at least five times the contribution of salvage synthesis. The measurements were repeated 24 hours after a 400-mg/kg dose of N-phosphonacetyl-L-aspartic acid. De-novo synthesis was substantially inhibited in all tissues and tumors after this treatment, although significant residual activity was observed in the intestine and L1210 cells. Nettesheim carcinoma was the only tumor or tissue to show a significant increase in salvage synthesis after N-phosphonacetyl-L-aspartic acid treatment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEOTIDES
KW  - PYRIMIDINES
KW  - NUCLEOSIDES
KW  - ANIMAL models in research
KW  - ASPARTIC acid
KW  - BIOCHEMISTRY
N1  - Accession Number: 13706572; Zaharevitz, Daniel W. 1 Anderson, Lawrence W. 1 Malinowski, Nancy M. 1 Hyman, Roosevelt 1 Strong, John M. 1 Cysyk, Richard L. 1; Affiliation:  1: Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, USA; Source Info: 11/15/92, Vol. 210 Issue 1, p293; Subject Term: NUCLEOTIDES; Subject Term: PYRIMIDINES; Subject Term: NUCLEOSIDES; Subject Term: ANIMAL models in research; Subject Term: ASPARTIC acid; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Harris, Curtis C.
T1  - "Tumor Suppressors, Oncogenes, and Human Cancer".
JO  - Science
JF  - Science
Y1  - 1992/11/21/11/20/92 Supplement
VL  - 258
M3  - Article
SP  - 18
EP  - 19
SN  - 00368075
AB  - The article presents a summary of the plenary lecture "Tumor Suppressors, Oncogenes and Human Cancer," delivered by Curtis C. Harris of the National Cancer Institute in the United States. Key issues discussed in the lecture include a description of proto-oncogenes, the epigenetic and genetic changes caused by carcinogens that can activate proto-oncogenes, the probability of the loss of function of tumor suppressor genes and the functional significance of gene abnormalities that are associated with cancer.
KW  - ANTIONCOGENES
KW  - PROTO-oncogenes
KW  - CANCER genes
KW  - CANCER genetics
KW  - TUMORS
KW  - CANCER
KW  - SCIENCE
KW  - LECTURES & lecturing
KW  - UNITED States
N1  - Accession Number: 24671019; Harris, Curtis C. 1; Affiliation:  1: National Cancer Institute; Source Info: 11/20/92 Supplement, Vol. 258, p18; Subject Term: ANTIONCOGENES; Subject Term: PROTO-oncogenes; Subject Term: CANCER genes; Subject Term: CANCER genetics; Subject Term: TUMORS; Subject Term: CANCER; Subject Term: SCIENCE; Subject Term: LECTURES & lecturing; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yanovski, Susan Zelitch
AU  - Leet, Melissa
AU  - Yanovski, Jack A.
AU  - Flood, Marilvn
AU  - Gold, Philip W.
AU  - Kissileff, Harry R.
AU  - Walsh, B. Timothy
T1  - Food selection and intake of obese women with binge-eating disorder.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1992/12//
VL  - 56
IS  - 6
M3  - Article
SP  - 975
EP  - 980
SN  - 00029165
AB  - We studied food selection and intake of 19 women [body mass index (in kg/m²) < 30], 10 of whom met proposed DSM-IV criteria for binge-eating disorder (BED). All subjects ate two multicourse meals in the laboratory, and were given tape-recorded instructions at each meal either to binge or eat in a normal fashion. Subjects with BED consumed significantly more energy than did subjects without BED at both the binge [12 400 vs 8440 kJ (2963 vs 2017 kcal), P < 0.005] and normal [9810 vs 6870 kJ (2343 vs 1640 kcal), P < 0.02] meals. During the binge meal subjects with BED consumed a greater percentage of energy as fat (38.9% vs 33.5%, P < 0.002) and a lesser percentage as protein (11.4% vs 15.4%, P < 0.01) than did subjects without BED. There were no differences in macronutrient composition of food choices between groups in the normal meal. Obese women who meet criteria for BED show differences in both intake and macronutrient composition of food choices from obese women who do not meet these criteria when asked to eat in a laboratory setting, supporting the validity of this new diagnosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - binge eating
KW  - depression
KW  - food intake
KW  - food selection
KW  - obesity
N1  - Accession Number: 94403086; Yanovski, Susan Zelitch 1,2,3,4; Leet, Melissa 1,2,3,4; Yanovski, Jack A. 1,2,3,4; Flood, Marilvn 1,2,3,4; Gold, Philip W. 1,2,3,4; Kissileff, Harry R. 1,2,3,4; Walsh, B. Timothy 1,2,3,4; Affiliations: 1: Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD; 2: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD; 3: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, St Luke's-Roosevelt Hospital, NY; 4: Obesity Research Center, St Luke's-Roosevelt Hospital, NY; Issue Info: Dec1992, Vol. 56 Issue 6, p975; Author-Supplied Keyword: binge eating; Author-Supplied Keyword: depression; Author-Supplied Keyword: food intake; Author-Supplied Keyword: food selection; Author-Supplied Keyword: obesity; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105849713
T1  - Food selection and intake of obese women with binge-eating disorder.
AU  - Yanovski SZ
AU  - Leet M
AU  - Yanovski JA
AU  - Flood M
AU  - Gold PW
AU  - Kissileff HR
AU  - Walsh BT
Y1  - 1992/12//
N1  - Accession Number: 105849713. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Eating Disorders -- Physiopathology
KW  - Eating
KW  - Food Preferences
KW  - Obesity -- Physiopathology
KW  - Adult
KW  - Dietary Fats -- Administration and Dosage
KW  - Energy Intake
KW  - Female
SP  - 975
EP  - 980
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 56
IS  - 6
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892.
U2  - PMID: 1442665.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Burke, Gregory L.
AU  - Savage, Peter J.
AU  - Manolio, Teri A.
AU  - Sprafka, J. Michael
AU  - Wagenknecht, Lynne E.
AU  - Sidney, Stephen
AU  - Perkins, Laura L.
AU  - Liu, Kiang
AU  - Jacobs Jr., David R.
T1  - Correlates of Obesity in Young Black and White Women: The CARDIA Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/12//
VL  - 82
IS  - 12
M3  - Article
SP  - 1621
EP  - 1625
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Although differences in obesity between Blacks and Whites are well documented in adult women, less information is available on potential correlates of these differences, especially in young adults. Methods. The association between behavioral and demographic factors and body size was assessed in 2801 Black and White women aged 18 to 30 years. Results. Black women had significantly higher age-adjusted mean body mass index and subscapular skinfold thickness than did White women. Obesity had different associations with age and education across racial groups. A positive relationship between age and obesity was seen in Black women but not in White women, whereas a negative association between education and body size was noted only in White women. Potential contributing factors to the increased prevalence of obesity in Black women include a more sedentary lifestyle, higher energy intake, earlier menarche, and earlier age at first childbirth. Conclusions. The difference in obesity across race could not be explained completely by these factors, since within virtually all strata, Black women had higher body mass indexes. Further investigation is needed to develop interventional strategies to prevent or reduce excess levels of obesity in Black women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OBESITY
KW  - BLACK women
KW  - WHITE women
KW  - YOUNG adults
KW  - AGE
KW  - EDUCATION
KW  - BODY size
N1  - Accession Number: 9306166049; Burke, Gregory L. 1 Savage, Peter J. 2 Manolio, Teri A. 2 Sprafka, J. Michael 3 Wagenknecht, Lynne E. 1 Sidney, Stephen 4 Perkins, Laura L. 5 Liu, Kiang 6 Jacobs Jr., David R. 3; Affiliation:  1: Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC  2: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md.  3: School of Public Health, University of Minnesota, Minneapolis  4: Division of Research, Kaiser Permanente Medical Care Program, Oakland, Calif.  5: School of Public Health, University of Alabama, Birmingham  6: Department of Community Health, Northwestern University Medical School, Chicago, Ill.; Source Info: Dec1992, Vol. 82 Issue 12, p1621; Subject Term: OBESITY; Subject Term: BLACK women; Subject Term: WHITE women; Subject Term: YOUNG adults; Subject Term: AGE; Subject Term: EDUCATION; Subject Term: BODY size; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 5p; Illustrations: 7 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brown, Linda Morris
AU  - Everett, George D.
AU  - Burmeister, Leon F.
AU  - Blair, Aaron
T1  - Hair Dye Use and Multiple Myeloma in White Men.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1992/12//
VL  - 82
IS  - 12
M3  - Article
SP  - 1673
EP  - 1674
PB  - American Public Health Association
SN  - 00900036
AB  - In recent reports, multiple myeloma has been linked to use of hair coloring products containing mutagenic and carcinogenic chemicals. A population-based case-control study in Iowa of 173 White men with multiple myeloma and 650 controls obtained information on hair dye use. Risk of multiple myeloma was significantly elevated (OR = 1.9) among hair dye users and was greatest among those using hair dyes at least once a month for a year or more (OR = 4.3). These data, along with results from other studies, suggest that use of hair dyes contributes to the development of multiple myeloma. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MULTIPLE myeloma
KW  - HAIR -- Dyeing & bleaching
KW  - DYES & dyeing -- Equipment & supplies
KW  - CHEMICALS
KW  - WHITE men
KW  - IOWA
N1  - Accession Number: 9306166061; Brown, Linda Morris 1 Everett, George D. 2 Burmeister, Leon F. 3 Blair, Aaron 1; Affiliation:  1: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Md.  2: Department of Internal Medicine, Orlando Regional Medical Center, Orlando, Fla.  3: Department of Preventive Medicine, University of Iowa, Iowa City; Source Info: Dec1992, Vol. 82 Issue 12, p1673; Subject Term: MULTIPLE myeloma; Subject Term: HAIR -- Dyeing & bleaching; Subject Term: DYES & dyeing -- Equipment & supplies; Subject Term: CHEMICALS; Subject Term: WHITE men; Subject Term: IOWA; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 333248 All other industrial machinery manufacturing; NAICS/Industry Codes: 333249 Other Industrial Machinery Manufacturing; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Adams, J. D.;
AU  - Arbuck, S. G.;
AU  - Trimble, E.;
AU  - Hayn, R.;
AU  - Vena, D.;
AU  - Barrett, J.;
AU  - Hawkins, M. J.;
AU  - Fallavollita, A.;
T1  - Taxol drug development and an interim report on the treatment referral center protocol, TRC-9103, taxol (NSC-125973) in refractory ovarian cancer
CT  - Taxol drug development and an interim report on the treatment referral center protocol, TRC-9103, taxol (NSC-125973) in refractory ovarian cancer
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1992/12/01/
VL  - 27
IS  - Dec
SP  - P
EP  - R
AD  - Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer Institute, Executive Plaza North, Room 707, Bethesda, MD 20892, USA
N1  - Accession Number: 30-00987; Language: English; Trade Name: Taxol; Generic Name: Paclitaxel; Chemical Name: Paclitaxel--33069-62-4; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Investigational Drugs
N2  - Based on response rates of 20-36% in Phase II trials in refractory ovarian cancer patients, the National Cancer Institute is making taxol (paclitaxel) available to patients with refractory ovarian cancer who are not eligible for clinical trials of higher priority. Eligible patients have received at least three prior anticancer regimens, were ECOG performance status 0-3 and have reasonable bone marrow and organ function. Taxol 135 mg/sq m is administered every 3 weeks with G-CSF in subsequent courses if necessary. Preliminary response rate in 245 patients is 25%. Myelosuppression is the major toxicity. These results in refractory patients, some of whom had poor performance status and compromised organ function, confirm the response rates previously reported in Phase II trials.
KW  - Paclitaxel--ovarian neoplasms-;
KW  - Practice Interest Areas--Oncology--meeting presentations;
KW  - ASHP meeting abstracts--paclitaxel ovarian neoplasms therapy;
KW  - Ovarian neoplasms--paclitaxel--therapy;
KW  - Toxicity--paclitaxel--myelosuppression;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
T1  - Use of computer data bases in clinical pharmacy practice
CT  - Use of computer data bases in clinical pharmacy practice
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1992/12/01/
VL  - 27
IS  - Dec
SP  - PI
EP  - 35
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
N1  - Accession Number: 30-01643; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature; Institutional Pharmacy Practice
N2  - Computer databases pertaining to medicine and the health sciences are rapidly gaining popularity among health-care professionals. Knowledge and appropriate use of factual and bibliographic databases by pharmacists is imperative if pharmacy is to succeed in providing pharmaceutical care. This presentation provides an overview of computer databases that pertain to pharmacy practice and describes their utility in solving patient care problems.
KW  - ASHP meeting abstracts--online databases;
KW  - Databases--online--clinical pharmacists, use;
KW  - Clinical pharmacists--databases--online;
KW  - Drug information--databases--online;
KW  - Computers--databases--online, clinical pharmacy;
KW  - Pharmacy--databases--online;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
AU  - Lifshin, L. S.;
AU  - Mowery, D.;
AU  - Robinson, H.;
T1  - WMSHP: twenty-eight years of excellence
CT  - WMSHP: twenty-eight years of excellence
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1992/12/01/
VL  - 27
IS  - Dec
SP  - ASC
EP  - -21
AD  - Drug Information Service, Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 30-01392; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: History; Institutional Pharmacy Practice
N2  - The Washington Metropolitan Society of Hospital Pharmacists was founded in 1964 as the District of Columbia Society of Hospital Pharmacists by progressive hospital pharmacy leaders from the Washington metropolitan area. Fifty-five pharmacists attended the first business meeting on November, 1964 hosted by Sister Constantia at Georgetown University Hospital. On December 3, 1964, WSHP elected its first officers: President Henry Peters, President-elect William Briner, Secretary Sister Constantia, Treasurer Frank Cooper, and Board Members Milton Skolaut and Irwin Title. The WMSHP became an ASHP-affiliated chapter in March of 1965. During the late 1960s and early 1970s, the Society continued to develop. Liaison activities with other organizations were established and joint meetings were held with some. In 1971, the first Society newsletter (Capital Script) was published, and in October of 1978 the first Annual Seminar was held in Ocean City, Maryland. During the early 1980s, monthly e ucational programs were established, and continuing education credit was first offered to members in 1985. In 1986, the Society developed a formal policy and procedures manual. Small open-forum conferences were established in the late 1980s to improve communication and networking among area pharmacists. A research and education committee was formed in 1988, and a committee on public and professional affairs was formed in 1992. Each year, the WMSHP presents several awards, including the Hospital Pharmacist of the Year and the Upjohn Pharmacy Research Award. In addition, the Society offers a research grant to its members on a competitive basis. Today the WMSHP is a vibrant organization representing more than 320 members from the greater Washington region. Members of the Society are largely pharmacists who work in hospitals, managed-care facilities, home health care, federal agencies, and the pharmaceutical industry.
KW  - ASHP meeting abstracts--Washington Metropolitan Society of Hospital Pharmacists;
KW  - Washington Metropolitan Society of Hospital Pharmacists--activities--history;
KW  - Organizations--District of Columbia--WMSHP, history, activities;
KW  - Pharmacy--organizations--Washington Metropolitan Society of Hospital Pharmacists;
KW  - History--Washington Metropolitan Society of Hospital Pharmacists;
KW  - District of Columbia--organizations--Washington Metropolitan Society of Hospital Pharmacists;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Imm, K.;
AU  - Mays, D.;
AU  - Gross, J.;
AU  - Shiflett, S.;
AU  - Gallelli, J. F.;
AU  - \ET/;
T1  - NIH Clinical Center Pharmacy Department: past, present, and future
CT  - NIH Clinical Center Pharmacy Department: past, present, and future
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1992/12/01/
VL  - 27
IS  - Dec
SP  - RXD
EP  - -09
AD  - Pharmacy Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 30-01384; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: History; Institutional Pharmacy Practice
N2  - The Clinical Center is the research hospital of the National Institutes of Health (NIH), the federal government's primary facility for biomedical investigations. The NIH Clinical Center's Pharmacy Department provides patient-oriented pharmaceutical services of the highest quality emphasizing rational and effective pharmacotherapy and innovative research. The history of the NIH Clinical Center Pharmacy Department\M/its past, present, and future\M/is presented in a pictorial display. Old photographs and documents demonstrating the growth and development of the Department since its beginning in 1953 will be shown.
KW  - ASHP meeting abstracts--history, hospital pharmacy services;
KW  - Pharmacy services--hospitals--history;
KW  - Pharmacy, institutional, hospital--services--history;
KW  - Administration--pharmacy services--history;
KW  - History--pharmacy services--hospitals;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-01384&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Grothe, D. R.;
T1  - Pharmacotherapy of late life depression
CT  - Pharmacotherapy of late life depression
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1992/12/01/
VL  - 27
IS  - Dec
SP  - SPG
EP  - -18
AD  - National Institutes of Health, 9000 Rockville Pike Building 10, Room 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 30-01258; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - The purpose of this presentation is to update the pharmacist on the current pharmacotherapeutic treatment recommendations and their monitoring in geriatric patients with depression. The content of this presentation is based upon up to date research reports, as well as the authors' own experience in working with depressed geriatric inpatients on the geriatric psychopharmacology research unit at the National Institute of Mental Health. In conclusion, late life depression is treatable with standard tricyclic antidepressants, serotonin specific up-take blockers, and the monoamine oxidase inhibitor type B agents. Depression in elderly is more frequently encountered than in younger age groups, and should be viewed as a treatable condition, rather than a normal reaction to aging.
KW  - ASHP meeting abstracts--geriatrics;
KW  - Depression--geriatrics--therapy;
KW  - Geriatrics--depression--therapy;
KW  - Antidepressants--therapy--geriatrics;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Brown, Martin
AU  - Christiansen, Jens
AU  - Philips, Peter
AD  - National Cancer Institute
AD  - Mount Holyoke College
AD  - U UT
T1  - The Decline of Child Labor in the U.S. Fruit and Vegetable Canning Industry: Law or Economics?
JO  - Business History Review
JF  - Business History Review
Y1  - 1992///Winter
VL  - 66
IS  - 4
SP  - 723
EP  - 770
SN  - 00076805
N1  - Accession Number: 0321297; Keywords: Child Labor;  Law; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199406
N2  - Child labor in the U.S. economy declined significantly between 1880 and 1920. This case study of the fruit and vegetable canning industry examines variations in laws, technology, and income across states and time to assess the relative importance of legal and economic factors in reducing the employment of children. The authors find that economic factors, especially a technologically driven shift toward a greater demand for adult labor, were relatively more important. While economic development was often a precondition for legal restrictions on child labor, compulsory schooling and child labor laws restricted the employment of children in technologically backward canneries.
KW  - Food; Beverages; Cosmetics; Tobacco; Wine and Spirits          L66
KW  - Labor Force and Employment, Size, and Structure          J21
KW  - Labor Law          K31
L3  - http://journals.cambridge.org/action/displayBackIssues?jid=BHR
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UR  - http://journals.cambridge.org/action/displayBackIssues?jid=BHR
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Baker, Paul T.
AU  - Garruto, Ralph M.
T1  - Health Transition: Examples from the Western Pacific.
JO  - Human Biology
JF  - Human Biology
Y1  - 1992/12//
VL  - 64
IS  - 6
M3  - Article
SP  - 785
EP  - 789
SN  - 00187143
AB  - Information about several papers discussed at a symposium on health transition in the Pacific region is presented. It is suggested how studies of human populations undergoing the transition can help to predict the developing health problems of the countries. It is also examined how such studies can serve as guides for research strategies on how specific gene-environment interactions operate to produce intra- and interpopulation differences in the human phenotype.
KW  - CONFERENCES & conventions
KW  - GENETICS
KW  - EPIDEMIOLOGY
KW  - PHENOTYPE
KW  - PACIFIC Area
KW  - SOUTHEAST Asia
KW  - EPIDEMIOLOGIC TRANSITION
KW  - HEALTH TRANSITION
KW  - MORTALITY
KW  - RESEARCH DESIGN
N1  - Accession Number: 24688553; Baker, Paul T. 1 Garruto, Ralph M. 2; Affiliation:  1: Department of Anthropology, Pennsylvania State University, University Park, PA 16802  2: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Source Info: Dec92, Vol. 64 Issue 6, p785; Subject Term: CONFERENCES & conventions; Subject Term: GENETICS; Subject Term: EPIDEMIOLOGY; Subject Term: PHENOTYPE; Subject Term: PACIFIC Area; Subject Term: SOUTHEAST Asia; Author-Supplied Keyword: EPIDEMIOLOGIC TRANSITION; Author-Supplied Keyword: HEALTH TRANSITION; Author-Supplied Keyword: MORTALITY; Author-Supplied Keyword: RESEARCH DESIGN; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yanagihara, Richard
T1  - Human T-Cell Lymphotropic Virus Type I Infection and Disease in the Pacific Basin.
JO  - Human Biology
JF  - Human Biology
Y1  - 1992/12//
VL  - 64
IS  - 6
M3  - Article
SP  - 843
EP  - 854
SN  - 00187143
AB  - Human T-cell lymphotropic virus type I (HTLV-I). the cause of adult T-cell leukemia/lymphoma (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), is widespread in the Pacific basin. Modes of virus transmission include blood transfusion (and intravenous drug use), breast milk, and sexual intercourse. High prevalences of HTLV-I infection and disease occur among the inhabitants of southwestern Japan and among first- and second-generation (issei and nisei) Japanese-Americans in the Hawaiian Islands. Other Pacific populations with high prevalences of HTLV-I infection include several remote groups in West New Guinea. Papua New Guinea, the Solomon Islands. and Vanuatu, which have had no contact with Japanese or Africans. By contrast. Micronesian and Polynesian populations. even those with prolonged contact with Japanese. exhibit low prevalences or no evidence of HTLV-l infection. Low prevalences of infection are also found in Australia. except among some aboriginal populations. Changing patterns of HTLV-I infection and disease are no better exemplified than in Japan. where striking reductions in transfusion-acquired infection and subsequent development of HAM/TSP have followed the institution of nationwide screening of blood donors for HTLV-I infection. Furthermore. virus transmission from mother to infant by means of infected breast milk has been markedly curtailed in HTLV-l-hyperendemic regions in Japan by interrupting the practice of breast feeding by HTLV-I-infected mothers. The next frontier of HTLV-I research is in Melanesia. where highly divergent sequence variants of HTLV-l have been discovered. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human Biology is the property of Wayne State University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUKEMIA
KW  - LYMPHOMAS
KW  - JAPANESE
KW  - SEXUAL intercourse
KW  - JAPAN
KW  - VANUATU
KW  - MELANESIA
KW  - EVOLUTION
KW  - MICRONESIA
KW  - MYELOPATHY
KW  - POLYNESIA
KW  - RETROVIRUS
N1  - Accession Number: 24688557; Yanagihara, Richard 1; Affiliation:  1: Laboratory of Central Nervous System Studies, National Institute of NeuroIogicaI Disorders and Stroke, National Institutes of Health, Bldg. 36, Rm. 5B-21, Bethesda, MD 20892; Source Info: Dec92, Vol. 64 Issue 6, p843; Subject Term: LEUKEMIA; Subject Term: LYMPHOMAS; Subject Term: JAPANESE; Subject Term: SEXUAL intercourse; Subject Term: JAPAN; Subject Term: VANUATU; Subject Term: MELANESIA; Author-Supplied Keyword: EVOLUTION; Author-Supplied Keyword: MICRONESIA; Author-Supplied Keyword: MYELOPATHY; Author-Supplied Keyword: POLYNESIA; Author-Supplied Keyword: RETROVIRUS; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cohn, Deborah A.
AU  - Silver, Daniel H.
AU  - Cowan, Carolyn P.
AU  - Cowan, Philip A.
AU  - Pearson, Jane
T1  - Working Models of Childhood Attachment and Couple Relationships.
JO  - Journal of Family Issues
JF  - Journal of Family Issues
Y1  - 1992/12//
VL  - 13
IS  - 4
M3  - Article
SP  - 432
EP  - 449
SN  - 0192513X
AB  - Previous research has documented connections between adults' working models of child- hood attachment relationships and the quality of parent-child relationships, but less attention has been devoted to examining such links for intimate adult relationships. Twenty-seven married couples were given George, Kaplan, and Main's Adult Attachment Interview and cach person was rated as either secure or insecure with respect to attachment. Self-report measures of satisfaction with couple communication and marital relations and laboratory observations of couple interactions were collected. Results showed that self-reported marital satisfaction was not related to adult attachment classifications for either husbands or wives. However, observational ratings of couple interaction yielded differences for husbands. As compared to husbands classified as insecure, secure husbands were likely to be in better- functioning couples who engaged in more positive and fewer conflictual behaviors. In addition, couples joint attachment classifications were related to observed couple behavior. Insecure-secure and secure-secure dyads did not differ, but both groups showed less conflict and were rated as better functioning than were insecure-insecure dyads. These findings suggest that a secure partner may buffer the negative effects of insecure attachment on the marital relationship. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PARENT & child
KW  - MARRIED people
KW  - DOMESTIC relations
KW  - DYADIC communication
KW  - COUPLES
KW  - HUSBAND & wife
KW  - FAMILY RELATIONS AND PROBLEMS
KW  - THEORETICAL MODELS
N1  - Accession Number: 9305055417; Cohn, Deborah A. 1 Silver, Daniel H. 2 Cowan, Carolyn P. 2 Cowan, Philip A. 2 Pearson, Jane 3; Affiliation:  1: University of Virginia  2: University of California, Berkeley  3: National Institute of Mental Health; Source Info: Dec92, Vol. 13 Issue 4, p432; Subject Term: PARENT & child; Subject Term: MARRIED people; Subject Term: DOMESTIC relations; Subject Term: DYADIC communication; Subject Term: COUPLES; Subject Term: HUSBAND & wife; Author-Supplied Keyword: FAMILY RELATIONS AND PROBLEMS; Author-Supplied Keyword: THEORETICAL MODELS; Number of Pages: 18p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 6623
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Korge, Bernhard P.
AU  - Compton, John G.
AU  - Steinert, Peter M.
AU  - Mischke, Dietmar
T1  - The Two Size Alleles of Human Keratin 1 Are Due to a Deletion in the Glycine-Rich Carboxyl-Terminal V2 Subdomain.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1992/12//
VL  - 99
IS  - 6
M3  - Article
SP  - 697
EP  - 702
SN  - 0022202X
AB  - Two size variants of the type II human keratin 1 protein chain, termed 1a and 1b, have been described previously. Using amplification of genomic DNA by the polymerase chain reaction and sequence analysis we show here that the difference between these two alleles is due to a deletion of 21 bp in sequences encoding the V2 subdomain. This deletion corresponds to an entire glycine loop of seven amino acids. Pedigree analysis showed that the alleles are inherited as normal Mendelian traits. No additional alleles were detected in a survey of 88 alleles from 44 unrelated individuals, and the allelic frequency of 1a and 1b was 0.61 and 0.39. To determine the molecular basis of inherited dermatoses it is preferable to perform genetic linkage studies utilizing candidate genes directly as polymorphic markers. The PCR-based keratin 1 alleles characterized here, together with previously described PCR-based size variants in the keratin 10 gene, provide useful markers for the keratin clusters on chromosome 12 and 17, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATIN
KW  - DNA
KW  - SKIN diseases
KW  - GENETICS
KW  - AMINO acids
KW  - GLYCINE
N1  - Accession Number: 12614149; Korge, Bernhard P. 1 Compton, John G. 1 Steinert, Peter M. 1 Mischke, Dietmar 2; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Institute for Experimental Oncology and Transplantation Medicine, University Medical Center Rudolf Virchow, Free University of Berlin, Berlin, F.R.G.; Source Info: Dec92, Vol. 99 Issue 6, p697; Subject Term: KERATIN; Subject Term: DNA; Subject Term: SKIN diseases; Subject Term: GENETICS; Subject Term: AMINO acids; Subject Term: GLYCINE; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12614149
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Carroll, Raymond J.
AU  - Li, Ker-Chau
AD  - TX A&M U
AD  - National Cancer Institute
T1  - Measurement Error Regression with Unknown Link: Dimension Reduction and Data Visualization
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1992/12//
VL  - 87
IS  - 420
SP  - 1040
EP  - 1050
SN  - 01621459
N1  - Accession Number: 0277536; Keywords: Measurement Error;  Regression; Publication Type: Journal Article; Update Code: 199306
N2  - A general nonlinear regression problem is considered with measurement error in the predictors. We assume that the response is related to an unknown linear combination of a multidimensional predictor through an unknown link function. Instead of observing the predictor, we instead observe a surrogate with the property that its expectation is linearly related to the true predictor with constant variance. We identify an important transformation of the surrogate variable. Using this transformed variable, we show that if one proceeds with the usual analysis ignoring measurement error, then both ordinary least squares and sliced inverse regression yield estimates which consistently estimate the true regression parameter, up to a constant of proportionality. We derive the asymptotic distribution of the estimates. A simulation study is conducted applying sliced inverse regression in this context.
KW  - Single Equation Models; Single Variables: General          C20
L3  - http://amstat.tandfonline.com/loi/uasa20
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UR  - http://amstat.tandfonline.com/loi/uasa20
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Stansfield, Ian
AU  - Grant, Christopher M.
AU  - Tuite, Akhmaloka
AU  - Tuite, Mick F.
T1  - Ribosomal association of the yeast SAL4 (SUP45) gene product: implications for its role in translation fidelity and termination.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992/12//
VL  - 6
IS  - 23
M3  - Article
SP  - 3469
EP  - 3478
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The <em>SAL4</em> gene of the yeast <em>Saccharomyces cerevisiae</em> encodes a novel translation factor (Sal4p) involved in maintaining translational fidelity. Using a polyclonal antibody raised against a Sal4p-β-galactosidase fusion protein, Sal4p was shown to be almost exclusively associated with the ribosomal fraction. Even when the ribosomes were treated with 0.8 M KCI, only low levels of Sal4p were detected in the post-ribosomal supernatant, suggesting a very strong affinity between Sal4p and the ribosome. Analysis of the distribution of Sal4p in the ribosomal population revealed that it was principally associated with 405 subunits, monosomes and polysomes. Incubation in high salt concentrations (0-8 M KCI) suggested that the affinity of Sat4p for the 40S subunit was lower than that for monosomes or polysomes. The Sal4p:ribosome association was only maintained when ribosomes were prepared in the presence of the translation elongation inhibitor cycloheximide; in uninhibited cells much lower levels of Sal4p were detectable in the 'run-off' polysomes. In view of these data, and given the stoichiometry of Sal4p to individual ribosomal proteins (estimated at less than 1:20), we suggest that Sal4p plays an ancillary role in translation termination. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Ribosomes
KW  - Saccharomyces cerevisiae
KW  - Cell organelles -- Formation
KW  - Leavening agents
KW  - Yeast
N1  - Accession Number: 15902726; Stansfield, Ian 1; Grant, Christopher M. 1,2; Tuite, Akhmaloka 1; Tuite, Mick F. 1; Affiliations: 1: Biological Laboratory, University of Kent, Canterbury. Kent, CT2 7NJ, UK; 2: Section on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA; Issue Info: Dec1992, Vol. 6 Issue 23, p3469; Thesaurus Term: Ribosomes; Subject Term: Saccharomyces cerevisiae; Subject Term: Cell organelles -- Formation; Subject Term: Leavening agents; Subject Term: Yeast; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 10p; Illustrations: 6 Diagrams, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pati, Sushma
AU  - DiSilvestre, Deborah
AU  - Brusilow, William S. A.
T1  - Regulation of the <em> Escherichia coli uncH</em> gene by mRNA secondary structure and translational coupling.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1992/12//
VL  - 6
IS  - 23
M3  - Article
SP  - 3559
EP  - 3566
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The <em>uncH</em> gene is one of the most poorly-expressed genes of the proton-translocating ATPase (une) operon of <em>Escherichia coli</em>. We constructed in-frame <em>lacZ</em> fusions to <em>uncH</em> and used site-directed mutagen-esis to decrease the stability of the putative mRNA secondary structure in the Shine and Dalgarno region for this gene. These mutations significantly increased the expression of <em>uncH</em>. We also used the <em>unc-lac</em> fusions to show that the insertion of stop codons and a frameshift mutation in <em>uncF</em>, the gene preceding <em>uncH</em>, caused a 10-fold reduction in <em>uncH</em> expression. Hybridization of total cellular RNA with a <em>lacZ</em>-specific probe indicated that transcriptional polarity could not account for the observed decrease in gene expression. These results demonstrate that <em>uncH</em> expression is controlled by mRNA sequences around the translational initiation region, and is translationally coupled to <em>uncF</em>, even in cases where the putative mRNA secondary structure is weakened or eliminated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Adenosine triphosphate
KW  - Genetics
KW  - Messenger RNA
KW  - Physical & theoretical chemistry
KW  - Genetic regulation
N1  - Accession Number: 15902847; Pati, Sushma 1,2; DiSilvestre, Deborah 1; Brusilow, William S. A. 3; Affiliations: 1: Department of Biochemistry, Wayne State University School of Medicine, Scott Hall, 540 E. Canfield Avenue, Detroit, Michigan 48201, USA; 2: Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA; 3: Department of Biochemistry, Wayne State University Schoot of Medicine, Scott Hall, 540 E. Canfield Avenue, Detroit, Michigan 48201, USA; Issue Info: Dec1992, Vol. 6 Issue 23, p3559; Thesaurus Term: Escherichia coli; Thesaurus Term: Adenosine triphosphate; Thesaurus Term: Genetics; Subject Term: Messenger RNA; Subject Term: Physical & theoretical chemistry; Subject Term: Genetic regulation; Number of Pages: 8p; Illustrations: 3 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105852008
T1  - Childhood-onset obsessive compulsive disorder.
AU  - Swedo SE
AU  - Leonard HL
AU  - Rapoport JL
Y1  - 1992/12//1992 Dec
N1  - Accession Number: 105852008. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7708110. 
KW  - Obsessive-Compulsive Disorder -- Diagnosis
KW  - Child
KW  - Combined Modality Therapy
KW  - Comorbidity
KW  - Mental Disorders -- Diagnosis
KW  - Mental Disorders -- Psychosocial Factors
KW  - Mental Disorders -- Therapy
KW  - Obsessive-Compulsive Disorder -- Psychosocial Factors
KW  - Obsessive-Compulsive Disorder -- Therapy
KW  - Prospective Studies
KW  - Serotonin Uptake Inhibitors -- Therapeutic Use
KW  - Human
SP  - 767
EP  - 775
JO  - Psychiatric Clinics of North America
JF  - Psychiatric Clinics of North America
JA  - PSYCHIATR CLIN NORTH AM
VL  - 15
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The clinical presentation of OCD in children and adolescents is quite similar to that in adults, with overlapping obsessional content and compulsive ritualistic patterns. In addition, both age groups provide essentially identical descriptions of the anxiety accompanying their compulsions and invoke similar mechanisms to resist acting out the ritualistic behavior. Responses to behavioral treatment and pharmacotherapy are similar across ages, and the disorder appears to be chronic and unremitting in the studied populations whether its onset is in childhood or adulthood. Conversely, the strong familial influence, male predominance, neuroendocrine abnormalities, presence of tics and other neurologic abnormalities, and possible impact on personality development suggest that pediatric OCD has important differences from its adult counterpart. Further investigations of these unique features of childhood-onset OCD are warranted and may provide etiologic clues to the disorder.Copyright © 1992 by Elsevier Inc.
SN  - 0193-953X
AD  - Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
U2  - PMID: 1461794.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105852009
T1  - Trichotillomania. An obsessive compulsive spectrum disorder?
AU  - Swedo SE
AU  - Leonard HL
Y1  - 1992/12//1992 Dec
N1  - Accession Number: 105852009. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7708110. 
KW  - Obsessive-Compulsive Disorder -- Diagnosis
KW  - Trichotillomania -- Diagnosis
KW  - Adolescence
KW  - Adult
KW  - Child
KW  - Child, Preschool
KW  - Clomipramine -- Therapeutic Use
KW  - Combined Modality Therapy
KW  - Desipramine -- Therapeutic Use
KW  - Double-Blind Studies
KW  - Female
KW  - Infant
KW  - Male
KW  - Middle Age
KW  - Myers-Briggs Type Indicator
KW  - Obsessive-Compulsive Disorder -- Classification
KW  - Obsessive-Compulsive Disorder -- Drug Therapy
KW  - Obsessive-Compulsive Disorder -- Psychosocial Factors
KW  - Prospective Studies
KW  - Psychological Tests
KW  - Trichotillomania -- Classification
KW  - Trichotillomania -- Drug Therapy
KW  - Trichotillomania -- Psychosocial Factors
KW  - Human
SP  - 777
EP  - 790
JO  - Psychiatric Clinics of North America
JF  - Psychiatric Clinics of North America
JA  - PSYCHIATR CLIN NORTH AM
VL  - 15
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Trichotillomania is a neglected neuropsychiatric disorder that only recently has received research attention. Based on clinical data, it appears far more common than previously believed. Like OCD, the behavior is recognized as senseless and undesirable, but is chronic and difficult to treat. The comorbidity, drug response data, familiality, and phenomenology of the disorder extend the concept of OCD to a spectrum of inappropriately released, excessive grooming behaviors. Although the discovery of clomipramine's effectiveness has provided relief to some trichotillomanics, further work is indicated to find regimens that provide long-term suppression of symptoms. Ongoing investigations of early-onset trichotillomania may reveal etiologic triggers, whereas studies that examine the similarities and differences between trichotillomania and OCD may help define the neurobiology of OCD, and possibly of other atypical impulse control disorders.Copyright © 1992 by Elsevier Inc.
SN  - 0193-953X
AD  - Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
U2  - PMID: 1461795.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105852009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105852012
T1  - Neurobiology of obsessive compulsive disorder.
AU  - Insel TR
AU  - Winslow JT
Y1  - 1992/12//1992 Dec
N1  - Accession Number: 105852012. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7708110. 
KW  - Brain -- Physiopathology
KW  - Obsessive-Compulsive Disorder -- Physiopathology
KW  - Receptors, Cell Surface -- Physiology
KW  - Serotonin -- Physiology
KW  - Brain Mapping
KW  - Brain -- Drug Effects
KW  - Delirium, Dementia, Amnestic, Cognitive Disorders -- Drug Therapy
KW  - Delirium, Dementia, Amnestic, Cognitive Disorders -- Physiopathology
KW  - Delirium, Dementia, Amnestic, Cognitive Disorders -- Psychosocial Factors
KW  - Obsessive-Compulsive Disorder -- Drug Therapy
KW  - Obsessive-Compulsive Disorder -- Psychosocial Factors
KW  - Receptors, Cell Surface -- Drug Effects
KW  - Serotonin Uptake Inhibitors -- Therapeutic Use
SP  - 813
EP  - 824
JO  - Psychiatric Clinics of North America
JF  - Psychiatric Clinics of North America
JA  - PSYCHIATR CLIN NORTH AM
VL  - 15
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - In this brief review of two of the neurobiologic aspects of OCD, two simplistic models have been suggested. Although these models reflect different perspectives, they may not be independent. For instance, the striatum, which is a focus for the neuroanatomic model, receives a dense serotonergic projection from the dorsal raphé. Similarly, as mentioned previously, combining PET studies and drug treatment demonstrates that the increased metabolic activity seen in the orbital cortex appears to normalize with serotonin uptake inhibitor treatment. Insights into the neurobiology of this syndrome will require combining perspectives as well as developing additional approaches. In addition, the search for neurobiologic abnormalities must be guided by a continuing regard for phenomenology. There is no reason, a priori, to assume that this syndrome subsumes only one disorder. The careful dissection of subgroups--whether based on symptom type, character style, or comorbid diagnoses--will be increasingly vital for understanding the results of neuropharmacologic and functional imaging studies.Copyright © 1992 by Elsevier Inc.
SN  - 0193-953X
AD  - Laboratory of Neurophysiology, National Institute of Mental Health, Poolesville, Maryland.
U2  - PMID: 1461798.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105852012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-06456-012
AN  - 2006-06456-012
AU  - Blaxton, Teresa A.
T1  - Applying Neural Networks to Cognition.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1992/12//
VL  - 37
IS  - 12
SP  - 1265
EP  - 1266
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06456-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Blaxton, Teresa A.; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognition; Cognitions; Cognitive Psychology; Neural Networks. Classification: Cognitive Processes (2340). Population: Human (10). Reviewed Item: Martindale, Colin. Cognitive Psychology: A Neural-Network Approach=Pacific Grove, CA: Brooks/Cole, 1991. 282 pp. $32.50 paperback; 1991. References Available: Y. Page Count: 2. Issue Publication Date: Dec, 1992. 
AB  - Reviews the book, Cognitive Psychology: A Neural-Network Approach by Colin Martindale (see record [rid]1990-98844-000[/rid]). Martindale's book is an attempt to interpret basic findings in various areas of cognitive psychology in terms of neural network formulations. Early on in the book (Chapter 3), he provides an overview of his own theory of cognition. In his model, cognitive operations are realized through the operation of several modules or analyzers devoted to various functions. Martindale does a very nice job of putting issues in their proper historical contexts. Martindale has taken on a somewhat difficult task in writing this book He has the challenge of introducing the naive reader to the basic field of cognitive psychology. The result is that the entire book is written on an introductory level, with respect to both descriptions of empirical findings on cognition and treatments of neural network architectures that might be used to model these findings. This book is an introduction to both cognition and neural networks, it will be more useful to certain classes of readers than to others. This book would be an excellent choice as a supplementary text to be used in conjunction with one written from an information-processing perspective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cognitive psychology
KW  - neural networks
KW  - cognition
KW  - 1992
KW  - Cognition
KW  - Cognitions
KW  - Cognitive Psychology
KW  - Neural Networks
KW  - 1992
U2  - Martindale, Colin. (1991); Cognitive Psychology: A Neural-Network Approach; Pacific Grove, CA: Brooks/Cole, 1991. 282 pp. $32.50 paperback; 0-534-14130-7 (Paperback).
DO  - 10.1037/031685
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06456-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-33339-015
AN  - 2015-33339-015
AU  - Lee, Wei-Hua
AU  - Javedan, Sam
AU  - Bondy, Carolyn A.
T1  - Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1992/12//
VL  - 12
IS  - 12
SP  - 4737
EP  - 4744
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Lee, Wei-Hua, NIH, Building 10, Room 10N262, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-33339-015. PMID: 1281494 Partial author list: First Author & Affiliation: Lee, Wei-Hua; Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebellum; Neurons; Neuroglia; Insulin-like Growth Factor. Minor Descriptor: Proteins. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: Dec, 1992. Publication History: Accepted Date: Jun 25, 1992; Revised Date: Jun 16, 1992; First Submitted Date: May 4, 1992. Copyright Statement: Society for Neuroscience. 1992. 
AB  - The interactions of insulin-like growth factors (IGFs) with the type I IGF receptor are modulated by a family of high-affinity IGF binding proteins (IGFBPs). One of these, IGFBPP, demonstrates a striking spatiotemporal relationship with IGF-I during cerebellar and retinal development. IGF-I mRNA is transiently expressed in large projection neurons-cerebellar Purkinje and retinal ganglion cells-while IGFBPS mRNA is selectively expressed by contiguous neuroglia- Bergmann glia in the cerebellum and Müller cells and astrocytes of the nerve fiber layer in the retina. IGF-I and IGFBP2 gene expression is not only neuroanatomically coordinated but also temporally synchronized, peaking together during the postnatal maturation of these structures. This pattern of IGF system expression suggests that IGFBPP is closely related to IGF-l’s action in the developing nervous system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - insulin-like growth factor
KW  - neurons
KW  - neuroglia
KW  - cerebellar development
KW  - 1992
KW  - Cerebellum
KW  - Neurons
KW  - Neuroglia
KW  - Insulin-like Growth Factor
KW  - Proteins
KW  - 1992
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-33339-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105850997
T1  - The pruritus of cholestasis and the opioid system.
AU  - Jones EA
AU  - Bergasa NV
AU  - Jones, E A
AU  - Bergasa, N V
Y1  - 1992/12/16/
N1  - Accession Number: 105850997. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Cholangitis, Sclerosing -- Complications
KW  - Pruritus -- Etiology
KW  - Pruritus -- Physiopathology
KW  - Receptors, Cell Surface -- Physiology
KW  - Female
KW  - Middle Age
KW  - Naloxone -- Therapeutic Use
KW  - Naltrexone -- Analogs and Derivatives
KW  - Naltrexone -- Therapeutic Use
KW  - Narcotic Antagonists -- Therapeutic Use
KW  - Pruritus -- Drug Therapy
KW  - Receptors, Cell Surface -- Drug Effects
SP  - 3359
EP  - 3362
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 268
IS  - 23
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md 20892
AD  - Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md 20892.
U2  - PMID: 1333541.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850997&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - Gen
ID  - 9999-11372-000
AN  - 9999-11372-000
AU  - Kohout, Frank J.
AU  - Berkman, Lisa F.
AU  - Evans, Denis A.
AU  - Cornoni-Huntley, Joan
T1  - Center for Epidemiological Studies Depression Scale--Short Form
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1993///
AD  - Kohout, Frank J.
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-11372-000. Acronyms: CES-D--Short. Partial author list: First Author & Affiliation: Kohout, Frank J.; University of Iowa, Iowa City, Iowa, United States. Release Date: 20120507. Correction Date: 20170213. Instrument Type: Rating Scale. Test Format: Responses are rated on the following scale: 0 (Hardly ever or never), 1 (Some of the time), and 2 (Much or most of the time).. Language: English. Constructs: Depression; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Other Versions: 9999-02942-000, Center for Epidemiological Studies Depression Scale, Original. 
N2  - Administration Method: Paper
AB  - Purpose: The short form of the CES-D briefly assesses depressive symptoms.
AB  - Description: The 11-item short form of the Center for Epidemiological Studies Depression Scale (CES-D; Kohout et al., 1993) is a self-report index of depressive symptoms. It is a brief version of the original 20-item CES-D, developed and field-tested in a multisite epidemiological study of the elderly, whose lengthy interviews demanded the briefest possible index of each health problem and risk factor. The short form was simulated from the original scale by collapsing response categories and computing scores on subsets of items. Responses were collapsed and recoded (0, 1, 2) and a total score is obtained by summing over the 11 items. Analyses on data from a cohort of people aged 65 years and above revealed a Cronbach's alpha reliability estimate of 81, nearly equal to the original 20-item CES-D. Factor analyses also indicated that the short form taps the same four symptom dimensions as the original CES-D (Depressed Affect, Positive Affect, Somatic Complaints, and Interpersonal Problems). Additionally, it can be administered in less than half the time needed for the original CES-D, with an average time savings of about 5 minutes per interview. (PsycTESTS Database Record (c) 2017 APA, all rights reserved)
KW  - Psychometric Properties
KW  - Center for Epidemiological Studies Depression Scale—Short Form
KW  - Depression Symptoms
KW  - Test Development
U5  - Center for Epidemiological Studies Depression Scale--Short Form (CES-D--Short) [Test Development]Two shorter forms of the CES-D Depression Symptoms Index. (AN: 1993-31893-001 from PsycINFO) Kohout, Frank J.; Berkman, Lisa F.; Evans, Denis A.; Cornoni-Huntley, Joan; May, 1993. Source: Journal of Aging and Health. 5(2), Sage Publications, US; May, 1993; Administration: Paper Age Group: Adulthood (18 yrs & older), Aged (65 yrs & older); Population: Human; Male; Female; Location: US; Sample: Adults Aged 64 yrs and Over Keywords: Psychometric Properties; Center for Epidemiological Studies Depression Scale—Short Form; Depression Symptoms; Test Development; Subjects: Major Depression; Psychiatric Symptoms; Psychodiagnosis; Rating Scales; Test Construction; Test Forms; Test Reliability;
DO  - 10.1037/t11372-000
L3  - Full; Full text; 999911372_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-11372-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-00543-000
AN  - 9999-00543-000
AU  - Richters, J. E.
AU  - Martinez, P. E.
T1  - Things I Have Seen and Heard Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1993///
AD  - Richters, J. E., University of Maryland, Department of Human Development and Institute for Child Study, Benjamin Building, Room 4104, College Park, Maryland, United States, 20742
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-00543-000. Partial author list: First Author & Affiliation: Richters, J. E. Release Date: 20121008. Correction Date: 20161010. Instrument Type: Rating Scale. Test Format: Children select 1 of 5 pictorial responses ranging from 0 (never) to 4 (many times). Individual item scores or summary scores can be used depending on the research question.. Language: English. Constructs: Violence Exposure; Classification: Development and Aging (5800); Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Other Versions: 9999-16214-000, Things I Have Seen and Heard Scale--Modified, Revision. 
N2  - Administration Method: Interview
AB  - Purpose: The Things I Have Seen and Heard Scale assesses the frequency of children's exposure to violence and violence-related activities at home and in the community.
AB  - Description: The Things I Have Seen and Heard Scale (Richters & Martinez, 1993) assesses the frequency, through child self-report, of exposure to violence and violencerelated activities at home and in the community. The instrument, developed for children in Grades 1 and 2, contains 20 items that probe young children’s exposure to violence or violence-related events (e. g., seeing someone arrested). The original version, developed in 1990 had only 15 items. The 1992 version expanded the form and added items related to violence within the home. A pictorial format is used to facilitate child comprehension of response options. On the response form five stacks of balls are depicted below each description of violence, each with a different number of balls, ranging from no balls (an empty circle) to four balls (representing many times). Interviewer-administered. Children must be taught how to indicate the frequency of their violence exposure using the visual scale of responses. The scale takes 5-10 minutes to administer. One-week test-retest reliability of the composite variable reflecting the sum of all instances of child-reported exposure was r = .81 for a random subsample of 21 children (Richters & Martinez, 1993a). (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Exposure to Violence
KW  - Things I Have Seen and Heard Scale
KW  - NIMH Community Violence Project
KW  - Child Victimization
U5  - Things I Have Seen and Heard Scale [Test Use]The NIMH Community Violence Project: I. Children as victims of and witnesses to violence. (AN: 1993-37897-001 from PsycINFO) Richters, John E.; Martinez, Pedro; Feb, 1993. Source: Psychiatry: Interpersonal and Biological Processes. 56(1), Guilford Publications, US; Feb, 1993; Administration: Interview Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs); Population: Human; Male; Female; Sample: Children Aged 6 to 10 Years, Living in an Inner-City Neighborhood Keywords: Exposure to Violence; Things I Have Seen and Heard Scale; NIMH Community Violence Project; Child Victimization; Subjects: Childhood Development; Domestic Violence; Neighborhoods; Victimization; Violence;
DO  - 10.1037/t00543-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-00543-000&site=ehost-live&scope=site
UR  - jrichter@nih.gov
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-06633-000
AN  - 9999-06633-000
AU  - Richters, John E.
AU  - Martinez, Pedro
T1  - Levonn
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1993///
AD  - Martinez, Pedro
AV  - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1  - Accession Number: 9999-06633-000. Partial author list: First Author & Affiliation: Richters, John E.; National Institute of Mental Health, Child and Adoleecant Disorders Research Branch, College Park, Maryland, United States. Release Date: 20130610. Test Format: Above each cartoon is a picture of three thermometers, each filled with a different level of mercury, labeled ''never,' 'some of the time,' and 'a lot of the time,' respectively.. Language: English. Constructs: Children's Distress; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). 
N2  - Administration Method: Interview
AB  - Purpose: The Levonn assesses young children's distress symptoms.
AB  - Description: The Levonn (Richters & Martinez, 1993) is a cartoon-based interview of children's distress symptoms. Children are shown a set of pictures and asked to respond to them using a thermometer response format. The pictures are based on the original work of Valla (1989) and modified to (1) depict the central character (Dominique) as an urban child (Levonn), (2) include depictions of symptoms associated with posttraumatic stress disorder (3) include a 2-3 sentence script with each cartoon, and (4) include a new response format for indicating frequency, consisting of thermometers filled with varying degrees of mercury. Following each cartoon description, children are asked to circle the thermometer indicating how often they feel like Levonn. One week test-retest data based on Levonn were collected from a random subsample of 1st- and 2nd-grade children. Reliability for the composite distress rating computed by summing across all symptom scores was high and significant. Across the full sampie of children tbe composite symptom score based on Levonn was significantly related to parant-rated Child Behavior Checklist (Achenbach & Edelbrock, 1983) scores and to parant ratings of children's distress based on the Checklist of Child Distress Symptoms (Richters and Martinez, 1990). (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW  - Child Distress Symptoms
KW  - Levonn
KW  - Test Development
KW  - Violence Exposure
KW  - Cartoon Depictions
KW  - Test Reliability
KW  - Test Validity
U5  - Levonn [Test Development]The NIMH Community Violence Project: II. Children's distress symptoms associated with violence exposure. (AN: 1993-37891-001 from PsycINFO) Martinez, Pedro; Richters, John E.; Feb, 1993. Source: Psychiatry: Interpersonal and Biological Processes. 56(1), Guilford Publications, US; Feb, 1993; Administration: Interview Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs); Population: Human; Male; Female; Sample: 6-10 Year Old Children Living in Low-Income, Moderately Violent Neighborhood Keywords: Child Distress Symptoms; Levonn; Test Development; Violence Exposure; Cartoon Depictions; Test Reliability; Test Validity; Subjects: Childhood Development; Distress; Exposure; Symptoms; Test Construction; Test Reliability; Test Validity; Violence;
DO  - 10.1037/t06633-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-06633-000&site=ehost-live&scope=site
UR  - jrichter@nih.gov
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
ID  - 104788078
T1  - Prevalence of volatile solvent inhalation among junior high school students in Japan and background life style of users.
AU  - Wada, K
AU  - Fukui, S
Y1  - 1993/01//
N1  - Accession Number: 104788078. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Ethnological Research
KW  - Life Style
KW  - Solvents
KW  - Substance Use Disorders -- Epidemiology
KW  - Adolescence
KW  - Child
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Incidence
KW  - Japan
KW  - Male
KW  - Social Environment
KW  - Substance Use Disorders -- Prevention and Control
SP  - 89
EP  - 100
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - In order to estimate the prevalence of volatile solvent inhalation among junior high school students in Japan and to assess certain characteristics of the lifestyle of these users, the authors surveyed 5240 students 12-15 years of age. This was the first major survey of the prevalence of volatile solvent inhalation among junior high school students in Japan, from the point of view of the number of subjects and schools. 1.5% of subjects were students who had inhaled solvents. The regularity of life style rhythm was more significantly disturbed in Lifetime Users than in Non-Users. School life and family life were significantly less relaxed for Lifetime Users than for Non-Users. Drinking alcohol and smoking had a strong relationship with inhaling volatile solvents. The authors suggest that greatly increasing education on the harmful effects of volatile solvents inhalation and increasing the frequency with which the entire family eats dinner together will be an effective prevention strategy in Japan.
SN  - 0965-2140
AD  - Division of Drug Dependence and Psychotropic Drug Clinical Research, National Institute of Mental Health, NCNP, Chiba-ken, Japan.
U2  - PMID: 8448518.
DO  - 10.1111/j.1360-0443.1993.tb02766.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104788078&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104788063
T1  - Patterns of alcohol consumption: beverage effects on gender differences.
AU  - Dawson, D A
Y1  - 1993/01//
N1  - Accession Number: 104788063. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Alcoholic Beverages
KW  - Alcoholism -- Epidemiology
KW  - Cross Sectional Studies
KW  - Female
KW  - Surveys
KW  - Human
KW  - Incidence
KW  - Male
KW  - Sex Factors
KW  - United States
SP  - 133
EP  - 138
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This Data Note reports findings from 22,102 current drinkers who responded in the US National Interview Survey in 1988. Mean estimated alcohol intake of males exceeded that of females by a factor of two. Males drank more per occasion (ratio 1.45) and drank on more occasion (1.41). Mean ethanol content per drink was slightly less for males (ratio 0.95) attributable to a decreased proportion of drinks being wine and liquor. When beverage preferences were taken into account, the drinking patterns of males and females showed no meaningful differences among persons with similar levels of overall ethanol intake. The results do not support the view that the difference between ethanol consumption of males and females are due primarily to males drinking more per occasion. Apparent differences in drinking patterns are attributable to differences in preferred beverage.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, MD 20857.
U2  - PMID: 8448504.
DO  - 10.1111/j.1360-0443.1993.tb02771.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104788063&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - CHAP
AU  - Gustman, Alan L.
AU  - Steinmeier, Thomas L.
AD  - Dartmouth College and NBER
AD  - TX Tech U, U MI Survey Research Center, and National Institute on Aging
A2  - Mitchell, Olivia S.
T1  - Cost-of-Living Adjustments in Pensions
T2  - As the workforce ages: Costs, benefits, and policy challenges
PB  - Frank W. Pierce Memorial Lectureship and Conference Series, no. 9.
PB  - Ithaca:
PB  - ILR Press
Y1  - 1993///
SP  - 147
EP  - 180
N1  - Accession Number: 0396357; Reviewed Book ISBN: 0-87546-196-4; Keywords: Cost of Living;  Pension; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 199610
KW  - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination          J14
KW  - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions          J32
KW  - Retirement; Retirement Policies          J26
KW  - Price Level; Inflation; Deflation          E31
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0396357&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Nagaraja, T.
AU  - Desiraju, T.
T1  - Regional alterations in the levels of brain biogenic amines, glutamate, GABA, and GAD activity due to chronic consumption of inorganic arsenic in developing and adult rats.
JO  - Bulletin of Environmental Contamination & Toxicology
JF  - Bulletin of Environmental Contamination & Toxicology
Y1  - 1993/01//
VL  - 50
IS  - 1
M3  - Article
SP  - 100
EP  - 107
SN  - 00074861
AB  - The article presents a study on the effects of chronic consumptions of inorganic arsenic on the brain biogenic amines, glutamate and glutamic acid decarboxylase (GAD) on adult rats. The study uses various methods such as administrating arsenic on the brain by gastric intubation, and dissecting different regions of the brain which biogenic amines are estimated. Results show the difference between the subject and the control groups on body weight, and the changes on the levels of amine.
KW  - RESEARCH
KW  - Arsenic
KW  - Biogenic amines
KW  - Glutamate decarboxylase
KW  - Rats as laboratory animals
KW  - Gastric intubation
KW  - Body weight
N1  - Accession Number: 70790400; Nagaraja, T. 1; Desiraju, T. 1; Affiliations: 1: Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, 560 029 Bangalore India; Issue Info: Jan1993, Vol. 50 Issue 1, p100; Thesaurus Term: RESEARCH; Subject Term: Arsenic; Subject Term: Biogenic amines; Subject Term: Glutamate decarboxylase; Subject Term: Rats as laboratory animals; Subject Term: Gastric intubation; Subject Term: Body weight; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 8p; Document Type: Article
L3  - 10.1007/BF00196547
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Chopra, R. K.
AU  - Raj, N. B. K.
AU  - Scally, J. P.
AU  - Donnenberg, A. D.
AU  - Adler, W. H.
AU  - Saah, A. J.
AU  - Margolick, J. B.
T1  - Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1993/01//
VL  - 91
IS  - 1
M3  - Article
SP  - 18
EP  - 24
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Previous studies have shown that exogenous IL-2 does not correct the reduction in phytohaemagglutinin (PHA)-induced proliferation of lymphocytes from HIV-1 infected (HIV+) individuals. We investigated the mechanism of this reduction to determine if reduced expression of the complete IL-2 receptor (IL-2R) was responsible. In a series of experiments, PH A-stimulated lymphocytes from a total of 89 HIV- and 93 HIV+ homosexual men from the Baltimore Multicentre AIDS Cohort Study (MACS) were studied to determine the expression of messages for the α and β subunits of the IL-2R, the binding of 125I-IL-2 to high affinity IL-2R, and the effect of IL-2 on cell proliferation. Compared to HIV- donors, PHA-stimulated lymphocytes from most HIV+ donors demonstrated (i) a reduction in high affinity IL-2R expression that correlated with the reduction in the IL-2-induced proliferative response; and (ii) a reduction in expression of both IL-2R α- and jβ-chain mRNA which may be responsible for decreased high affinity IL-2R expression. However, lymphocytes from some HIV+ individuals had borderline low IL-2-induced proliferation despite normal or elevated expression of high affinity IL-2R. These results suggest that decreased expression of IL-2R may account, at least in part, for the lower proliferative response of cells from HIV+ donors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-2
KW  - IMMUNE response -- Molecular aspects
KW  - LYMPHOCYTES
KW  - CELL proliferation
KW  - HIV-positive persons
KW  - PHYTOHEMAGGLUTININS
KW  - CELLULAR immunity
KW  - HIV-1
KW  - IL-2
KW  - IL-2 receptor
KW  - lymphocytes
KW  - phytohaemagglutinin
N1  - Accession Number: 16003073; Chopra, R. K. 1 Raj, N. B. K. 2,3 Scally, J. P. 1 Donnenberg, A. D. 2,3 Adler, W. H. 4 Saah, A. J. 5,6 Margolick, J. B. 1,6; Affiliation:  1: Department of Environmental Health Sciences, The Johns Hopkins University.  2: Department of Oncology, School of Medicine, The Johns Hopkins University.  3: Bone Marrow Transplantation Program, The Johns Hopkins University.  4: Clinical Immunology Section, Gerontology Research Centre, National Institute on Aging, Baltimore, MD, USA.  5: Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University.  6: The Baltimore Centre of The Multicentre AIDS Cohort Study, Baltimore, MD, USA.; Source Info: Jan1993, Vol. 91 Issue 1, p18; Subject Term: INTERLEUKIN-2; Subject Term: IMMUNE response -- Molecular aspects; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Subject Term: HIV-positive persons; Subject Term: PHYTOHEMAGGLUTININS; Subject Term: CELLULAR immunity; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: IL-2; Author-Supplied Keyword: IL-2 receptor; Author-Supplied Keyword: lymphocytes; Author-Supplied Keyword: phytohaemagglutinin; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107401536
T1  - Estrogen replacement therapy and breast cancer risk.
AU  - Brinton LA
AU  - Schairer C
Y1  - 1993/01//1/ 1/1993
N1  - Accession Number: 107401536. Language: English. Entry Date: 19950301. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 7910703. 
KW  - Hormone Replacement Therapy
KW  - Breast Neoplasms -- Epidemiology
KW  - Risk Factors
KW  - Breast Neoplasms -- Etiology
KW  - Treatment Duration
KW  - Estrogens -- Administration and Dosage
KW  - Female
SP  - 66
EP  - 79
JO  - Epidemiologic Reviews
JF  - Epidemiologic Reviews
JA  - EPIDEMIOL REV
VL  - 15
IS  - 1
PB  - Oxford University Press / USA
SN  - 0193-936X
AD  - Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892
U2  - PMID: 8405213.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hetherington, Marion M.
AU  - Spalter, Adela R.
AU  - Bernat, Aviva S.
AU  - Nelson, Mark L.
AU  - Gold, Philip W.
T1  - Eating Pathology in Bulimia Nervosa.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993/01//
VL  - 13
IS  - 1
M3  - Article
SP  - 13
EP  - 24
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Degree of eating pathology in bulimia nervosa was assessed using the Eating Behavior Rating Scale (EBRS) across three videotaped eating sessions Twelve bulimic and 12 non-eating disordered subjects participated in this study. All subjects were filmed during a baseline meal (ad libitum), a high-calorie meal and a low-calorie meal (both fixed amounts). Mean EBRS scores were significantly higher for bulimics (12.6 ± 1.7) than for controls (3.9 ± 0.9), suggesting a higher degree of eating pathology in these patients. Affect during eating was significantly more negative in the bulimic patients. EBR5 and affect scores were significantly correlated [r (11) = .813, p < .01]. Bulimics had a slower rate of eating than controls and took significantly longer to initiate eating. Scores of pathological eating correlated with scores on the Eating Attitudes Test and the Bulimic Investigatory Test-Edinburgh, indicating a relationship between objective measures of pathological eating and self-report measures of eating disorder symptoms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BULIMIA
KW  - EATING disorders
KW  - PATHOLOGY
KW  - PSYCHIATRIC rating scales
KW  - FOOD habits
KW  - SYMPTOMS
KW  - AFFECT (Psychology)
KW  - PATHOLOGICAL psychology
KW  - PATIENTS
N1  - Accession Number: 11928080; Hetherington, Marion M. 1 Spalter, Adela R. Bernat, Aviva S. 2 Nelson, Mark L. Gold, Philip W. 3; Affiliation:  1: Lecturer in Psychology, University of Dundee  2: Research Assistant at the National Institute of Mental Health, Bethesda  3: Chief of Clinical Neuroendocrinology at the National Institute of Mental Health, Bethesda; Source Info: Jan1993, Vol. 13 Issue 1, p13; Subject Term: BULIMIA; Subject Term: EATING disorders; Subject Term: PATHOLOGY; Subject Term: PSYCHIATRIC rating scales; Subject Term: FOOD habits; Subject Term: SYMPTOMS; Subject Term: AFFECT (Psychology); Subject Term: PATHOLOGICAL psychology; Subject Term: PATIENTS; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Martinez, Rick A.
AU  - Lebowitz, Barry D.
AU  - Cohen, Gene D.
T1  - FUNDING RESEARCH STRUCTURES.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1993/01//
VL  - 8
IS  - 1
M3  - Article
SP  - 19
EP  - 24
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - Research priorities established by the field of geriatric psychiatry are the principal source of ideas for investigations supported by the National Institute of Mental Health, the National Institute of Aging and a host of private organizations and foundations. Individuals, at various stages in their careers, can compete for federal stipends to pursue these research inquiries. Knowledge of the assortment of awards available is part of an overall strategy candidates need to develop in planning and maintaining productive research careers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GERIATRIC psychiatry
KW  - RESEARCH
KW  - PSYCHIATRY
KW  - GERONTOLOGY
KW  - OLDER people -- Mental health
KW  - UNITED States
KW  - funding
KW  - geriatric psychiatry
KW  - research
KW  - NATIONAL Institute of Mental Health (U.S.)
N1  - Accession Number: 12119037; Martinez, Rick A. 1 Lebowitz, Barry D. 2 Cohen, Gene D. 3; Affiliation:  1: Program Chief of Geriatric Psychiatry Research  2: Branch Chief, Aging Branch, NIMH, Mental Disorders of the Aging Branch, NIMH, Parklawn Building, Room 7 C-103, 5600 Fishers Lane, Rockville, Maryland 20857, USA  3: Acting Director, NIA, National Institute of Aging, Building 31, Room 3B-58, Bethesda, Maryland 20892, USA; Source Info: Jan1993, Vol. 8 Issue 1, p19; Subject Term: GERIATRIC psychiatry; Subject Term: RESEARCH; Subject Term: PSYCHIATRY; Subject Term: GERONTOLOGY; Subject Term: OLDER people -- Mental health; Subject Term: UNITED States; Author-Supplied Keyword: funding; Author-Supplied Keyword: geriatric psychiatry; Author-Supplied Keyword: research; Company/Entity: NATIONAL Institute of Mental Health (U.S.); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schneider, Lon S.
AU  - Martinez, Rick A.
AU  - Lebowitz, Barry D.
T1  - CLINICAL PSYCHOPHARMACOLOGY RESEARCH IN GERIATRICS: AN AGENDA FOR RESEARCH.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1993/01//
VL  - 8
IS  - 1
M3  - Article
SP  - 89
EP  - 93
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - The two main areas of geriatric clinical psychopharmacology research, depression and dementia, are reviewed. The issues for depression research include pharmacokinetics in the geriatric population and the relationship to efficacy and side-effects; the treatment of the medically ill and the very old; and maintenance and continuation treatments. In particular, the recommendations from the recently convened NIH Consensus Development Conference for the Diagnosis and Treatment of Depression in Late Life are discussed. The issues in dementia research include effective treatment of behavioral symptoms as well as severe and mild cognitive impairment; the development of better cholinesterase inhibitors; the application of other drugs; and the use of appropriate clinical trials methodology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GERIATRICS
KW  - RESEARCH
KW  - PSYCHOPHARMACOLOGY
KW  - DRUG therapy
KW  - PHARMACOLOGY
KW  - MENTAL depression
KW  - DEMENTIA
KW  - GERIATRIC psychiatry
KW  - UNITED States
KW  - clinical psychopharmacology
KW  - geriatric psychiatry
KW  - research
N1  - Accession Number: 12119637; Schneider, Lon S. 1 Martinez, Rick A. 2 Lebowitz, Barry D. 2; Affiliation:  1: University of Southern California School of Medicine, Los Angeles, USA  2: National Institute of Mental Health, Rockville, Maryland, USA; Source Info: Jan1993, Vol. 8 Issue 1, p89; Subject Term: GERIATRICS; Subject Term: RESEARCH; Subject Term: PSYCHOPHARMACOLOGY; Subject Term: DRUG therapy; Subject Term: PHARMACOLOGY; Subject Term: MENTAL depression; Subject Term: DEMENTIA; Subject Term: GERIATRIC psychiatry; Subject Term: UNITED States; Author-Supplied Keyword: clinical psychopharmacology; Author-Supplied Keyword: geriatric psychiatry; Author-Supplied Keyword: research; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Hendrickson, M A
AU  - Milne, G W A
AU  - Zaharevitz, D
T1  - CONCORD and CAMBRIDGE: comparison of computer-generated chemical structures with x-ray crystallographic data
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1993/01//Jan-Feb 1993
VL  - 33
IS  - 1
M3  - Article
SP  - 155
EP  - 163
SN  - 00952338
AB  - The structures of a number of molecules as determined by X-ray crystallography have been compared with the structures for the same molecules as calculated by the 3D structure generation program, CONCORD. In 41% of the cases, the calculated structures were essentially identical to those measured by X-ray diffraction. In most of the remainder, there were significant differences arising primarily from the inability of the structure generation program to predict the correct torsion angle at one or more rotatable bonds. The implications of these findings on the process of 3D database generation are discussed.
KW  - DATA structures (Computer science)
KW  - DATABASES
KW  - Chemical data
KW  - Computer programs
N1  - Accession Number: ISTA2800902; Hendrickson, M A 1; Milne, G W A; Zaharevitz, D; Affiliations: 1 : National Institutes of Health, Bethesda, MD;  Source Info: Jan-Feb 1993, Vol. 33 Issue 1, p155; Note: Update Code: 2800; Subject Term: DATA structures (Computer science); Subject Term: DATABASES; Author-Supplied Keyword: Chemical data; Author-Supplied Keyword: Computer programs; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Lee, Seung-Chul
AU  - Wang, Mary
AU  - McBride, O. Wesley
AU  - O'Keefe, Edward J.
AU  - Kim, In-Gyu
AU  - Steinert, Peter M.
T1  - Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/01//
VL  - 100
IS  - 1
M3  - Article
SP  - 65
EP  - 68
SN  - 0022202X
AB  - Trichohyalin is a major differentiation product of hard keratinizing tissues such as the inner root sheath and medullary cells of the hair follicle and the filiform papillae of the tongue, as well as terminally differentiating epidermal cells. It consists largely of quasi-repeating peptide repeats and functions primarily as an intermediate filament-associated protein in these tissues. By mapping with human-rodent somatic cell hybrids and fluorescent <em>in situ</em> hybridization, we demonstrate that its gene maps to chromosomal region 1q21. Interestingly, genes encoding several other structural proteins expressed during terminal differentiation in the epidermis map to this region, as do also several members of the S-100 class of small calcium-binding proteins. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - GENES
KW  - CHROMOSOMES
KW  - KERATIN
KW  - CELLS
KW  - TISSUES
N1  - Accession Number: 12354504; Lee, Seung-Chul 1 Wang, Mary 2,3 McBride, O. Wesley 2,3 O'Keefe, Edward J. 4 Kim, In-Gyu 1 Steinert, Peter M. 1; Affiliation:  1: Skin Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: National Institute of Arthritis and Musculoskeletal, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  3: Skin Diseases and Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  4: Department of Dermatology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, U.S.A.; Source Info: Jan1993, Vol. 100 Issue 1, p65; Subject Term: PROTEINS; Subject Term: GENES; Subject Term: CHROMOSOMES; Subject Term: KERATIN; Subject Term: CELLS; Subject Term: TISSUES; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12354504
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Raynaud, Françoise
AU  - Gerbaud, Pascale
AU  - Bouloc, Anne
AU  - Gorin, Isabelle
AU  - Anderson, Wayne B.
AU  - Evain-Brion, Danièle
T1  - Rapid Effect of Treatment of Psoriatic Erythrocytes with the Synthetic Retinoid Acitretin to Increase 8-Azido Cyclic AMP Bindings to the RI Regulatory Subunit.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/01//
VL  - 100
IS  - 1
M3  - Article
SP  - 77
EP  - 81
SN  - 0022202X
AB  - We have recently demonstrated a deficiency in the cyclic adenosine monophosphate (cAMP) - dependent protein kinases (PKA), the intracellular mediator of AMP, in psoriasis. This enzyme defect is expressed in fibroblasts and in red blood cells isolated from psoriatic patients. In these cells, the abnormality noted in cAMP binding to PKA correlates well with the severity of the disease and is corrected by long-term treatment with etretinate. In this study, we determined the effect of oral administration of acitretin in four psoriatic patients on the altered cAMP binding observed with the RI regulatory subunit of PKA in erythrocytes prepared from these patients. Acitretin (30 mg/day) induced a rapid (within 1 h) increase in the ability of the RI regulatory subunit of erythrocytes to bind the 8-azido[32P]cAMP photoaffinity analogue of cAMP. The maximal plateau for this effect of acitretin was observed within 24 h of treatment and preceded the clinical improvement of the disease. The effect of acitretin was dose-dependent, with the maximal response observed at 40 mg acitretin/d. In addition, the rapid exposure (15 mm) of erythrocytes isolated from untreated patients exhibiting severe psoriasis to acitretin also promoted an increase in binding of 8-azido[32P]cAMP to the RI cAMP binding protein. Retinoic acid and 13-<em>cis</em>-retinoic acid were as efficient as acitretin in inducing the increase in binding of 8- azido[32P]cAMP to the RI regulatory subunit, whereas arotinoid was without effect. These results suggest that acitretin may act to modify PKA (the RI regulatory subunit) at the post-transcriptional level, and this may reflect, in part, on the mechanism of action of this synthetic retinoid. Further, monitoring this biochemical event may be helpful in determining the choice of retinoid therapy and in the management of its pharmacology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ERYTHROCYTES
KW  - BLOOD cells
KW  - PROTEINS
KW  - ADENYLIC acid
KW  - PSORIASIS
KW  - PATIENTS
N1  - Accession Number: 12354923; Raynaud, Françoise 1 Gerbaud, Pascale 1 Bouloc, Anne 1 Gorin, Isabelle 2 Anderson, Wayne B. 3 Evain-Brion, Danièle 1; Affiliation:  1: Laboratoire de Physiopathologie du Développement, CNRS-Ecole Normale Supérieure.  2: Department of Dermatology, Hospital Tarner, Paris France.  3: Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jan1993, Vol. 100 Issue 1, p77; Subject Term: ERYTHROCYTES; Subject Term: BLOOD cells; Subject Term: PROTEINS; Subject Term: ADENYLIC acid; Subject Term: PSORIASIS; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12354923
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson, Ray
T1  - On the neural generators of the P300 component of the event-related potential.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1993/01//
VL  - 30
IS  - 1
M3  - Article
SP  - 90
EP  - 97
SN  - 00485772
AB  - The triarchic model of P300 amplitude (Johnson, 1986, 1988a) postulated that the overall amplitude of the P300 recorded at any given electrode site represented the summation of activity from different neural generators, each related to the processing of a different type of information. However, neither of these original accounts provided an explicit description of the methods required to establish experimentally the presence of multiple neural sources. This paper reviews the triarchic amplitude model, the subsequently obtained data that support the postulated presence of multiple generators underlying the P300, and the methods used to demonstrate the presence of these multiple sources. These methods are straightforward because it is only necessary to show that the portions of P300 amplitude associated with different experimental variables have different scalp distributions. The implications of the multiple-generator basis of P300 on such factors as component definition, neural source analyses, and the cognitive processes underlying its activity are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEUROPLASTICITY
KW  - NEURAL stimulation
KW  - ELECTROPHYSIOLOGY
KW  - ELECTRODES
KW  - MEMORY
KW  - FORMAL discipline
N1  - Accession Number: 11037219; Johnson, Ray 1; Affiliation:  1: Cognitive Neurophysiology Unit, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD.; Source Info: Jan1993, Vol. 30 Issue 1, p90; Subject Term: NEUROPLASTICITY; Subject Term: NEURAL stimulation; Subject Term: ELECTROPHYSIOLOGY; Subject Term: ELECTRODES; Subject Term: MEMORY; Subject Term: FORMAL discipline; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1469-8986.ep11037219
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2006-06468-064
AN  - 2006-06468-064
AU  - Lamb, Michael E.
T1  - Collected Essays on Infant Socialization.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1993/01//
VL  - 38
IS  - 1
SP  - 93
EP  - 94
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06468-064. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Infant Development; Social Influences; Socialization. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Lewis, Michael (Ed); Feinman, Saul (Ed). Social Influences and Socialization in Infancy=New York: Plenum Press, 1991. 348 pp. $49.50; 1991. References Available: Y. Page Count: 2. Issue Publication Date: Jan, 1993. 
AB  - Reviews the book, Social Influences and Socialization in Infancy edited by Michael Lewis and Saul Feinman (1991). The volume is introduced by an engaging and unfortunately brief chapter in which broad trends in the conceptualization and investigation of infant development are summarized. This sketch will provide a useful orientation, especially for new investigators, and it is regrettable that the editors did not provide a fuller and richer exploration of the historical era surveyed. It is also unfortunate that this chapter provides only a sketchy introduction to the rest of the book, it fails to relate the perspectives reflected in each of the chapters to theoretical positions and themes outlined in their historical synopsis. Overall, this book provides researchers with well-written and for the most part well-reasoned summaries of some important positions and approaches. It should thus serve as a useful guide to scholars attempting to make sense of the rapidly growing and increasingly disorganized literature on socialization in infancy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - infant development
KW  - social influences
KW  - socialization
KW  - infancy
KW  - 1993
KW  - Infant Development
KW  - Social Influences
KW  - Socialization
KW  - 1993
U2  - Lewis, Michael (Ed); Feinman, Saul (Ed). (1991); Social Influences and Socialization in Infancy; New York: Plenum Press, 1991. 348 pp. $49.50; 0-306-43632-9.
DO  - 10.1037/032983
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06468-064&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-34926-007
AN  - 2015-34926-007
AU  - Belcheva, Mariana
AU  - Barg, Jacob
AU  - Rowinski, Jan
AU  - Clark, W. Gregg
AU  - Gloeckner, Charles A.
AU  - Ho, Andrew
AU  - Gao, Xiao-Ming
AU  - Chuang, De-Maw
AU  - Coscia, Carmine
T1  - Novel opioid binding sites associated with nuclei of NG108-15 neurohybrid cells.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1993/01//
VL  - 13
IS  - 1
SP  - 104
EP  - 114
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Coscia, Carmine, E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO, US, 63104
N1  - Accession Number: 2015-34926-007. PMID: 8423466 Partial author list: First Author & Affiliation: Belcheva, Mariana; E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neural Receptors; Neurons; Opiates; Receptor Binding. Minor Descriptor: Peptides. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Jan, 1993. Publication History: Accepted Date: Jul 14, 1992; Revised Date: May 15, 1992; First Submitted Date: Dec 16, 1991. Copyright Statement: Society for Neuroscience. 1993. 
AB  - Nuclear opioid binding sites have been discovered in NG108-15 neurohybrid cells. Marker enzyme analyses as well as electron and fluorescence microscopy studies attested to the high degree of purity of the nuclear preparations. Immunohistochemical studies on cryostat sections of NG108-15 cells with an antibody to the opioid receptor corroborated a nuclear localization. ³H-[D-Pen²,D-Pen⁵]enkephalin (³H-DPDPE), ³H-[D-Ala²,D-Leu⁵] enkephalin (³H-DADLE), and ³H-diprenorphine binding parameters, Kd and Bmax values, and heterologous competition binding and stereospecificity data satisfied criteria for the presence of δ-opioid sites in purified nuclear preparations. Neither µ-([D-Ala²,mephe⁴,gly-ol⁵] enkephalin), dihydromorphine, nor κ-(U69593) specific binding was detectable in purified nuclear preparations. Rates of association and dissociation of 3H-[D-Ser2,L-Leu5]enkephalyl-Thr were comparable to values obtained previously for opioid receptors. Opioid binding was also shown in subnuclear preparations from NG108-15 cell cultures. Agonists, ³H-DADLE and ³H-DPDPE, bind with high affinity to nuclear membranes and with lower affinity to chromatin. In contrast, partial agonist ³H-diprenorphine high-affinity binding sites were predominant in chromatin, while low-affinity binding was found in the nuclear membrane. Accordingly, 5'-guanylylimidodiphosphate sensitivity of ³H-DADLE binding was detected in nuclear membranes but not in chromatin. Both agonist and partial agonist opioid binding to nuclear membrane and chromatin were abolished upon cycloheximide treatment of NG108-15 cells. Taken together, the results suggest that NG108-15 cells contain newly synthesized GTP binding regulatory protein (G-protein)-coupled δ-opioid receptors in nuclear membranes and uncoupled opioid binding sites in chromatin. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - opioid receptor
KW  - nucleus
KW  - neurohybrid cells
KW  - subcellular fractionation
KW  - opioid peptide
KW  - immunohistochemistry
KW  - 1993
KW  - Neural Receptors
KW  - Neurons
KW  - Opiates
KW  - Receptor Binding
KW  - Peptides
KW  - 1993
U1  - Sponsor: National Science Foundation. Grant: BNS 88-09462. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-85975-001
AN  - 1997-85975-001
AU  - Shirai, Yasuko
T1  - Jurisprudents' attitudes toward new reproductive technology: A pilot study.
JF  - Journal of Mental Health
JO  - Journal of Mental Health
Y1  - 1993///
VL  - 39
SP  - 107
EP  - 114
CY  - Japan
PB  - National Inst of Mental Health - Japan
SN  - 0915-065X
N1  - Accession Number: 1997-85975-001. Partial author list: First Author & Affiliation: Shirai, Yasuko; National Institute of Mental Health Japan, Ichikawa-shi, Japan. Release Date: 19970401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: Japanese. Major Descriptor: Adult Attitudes; Attorneys; Reproductive Technology. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: 1993. 
AB  - Surveyed 47 lawyers who attended a symposium on artificial reproductive technology. 81% agreed with the extrauteral fertilization of married couples, but 72% supported legal control on all forms of modern reproductive methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - attitudes toward artificial reproductive technology
KW  - lawyers
KW  - Japan
KW  - 1993
KW  - Adult Attitudes
KW  - Attorneys
KW  - Reproductive Technology
KW  - 1993
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-85975-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09723-011
AN  - 2005-09723-011
AU  - Kirch, Darrell G.
T1  - Infection and Autoimmunity as Etiologic Factors in Schizophrenia: A Review and Reappraisal.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1993///
VL  - 19
IS  - 2
SP  - 355
EP  - 370
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Kirch, Darrell G., National Institutes of Health, Bldg. 10, Rm. 4N-224, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-09723-011. PMID: 8322038 Partial author list: First Author & Affiliation: Kirch, Darrell G.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Etiology; Immunology; Infectious Disorders; Schizophrenia. Minor Descriptor: Central Nervous System; Environmental Effects; Genetics. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 16. Issue Publication Date: 1993. 
AB  - The focus of schizophrenia research has been turning from studies of structural and functional brain abnormalities to an increasing emphasis on possible etiologic factors. One etiologic hypothesis is that schizophrenia is the result of an infection (especially by a virus) or of an autoimmune reaction (perhaps following an infection) against central nervous system (CNS) tissue. Indirect evidence supporting this hypothesis includes possible geographic variance in the prevalence of schizophrenia, a season-of-birth effect, and observed associations between schizophrenia and prenatal exposure to viral epidemics. Several studies of cell-based and humoral immunity, as well as studies of cytokines, have indicated abnormalities in the immune function of schizophrenia patients, but many of these findings have not been replicated consistently. In addition, most observed alterations in immune function have been modest in degree and nonspecific. Attempts to identify a specific infectious agent or an antibody directed against CNS tissue have not produced a consistently replicable finding. In summary, no research evidence to date irrefutably indicates an infectious or autoimmune etiologic process in schizophrenia. It is probably unreasonable, however, to view schizophrenia as having a single cause. It is much more likely to be a heterogeneous disorder resulting from interactions between multiple factors, including the person's genetic endowment and various environmental influences. Infectious agents or CNS autoantibodies may well be among these environmental variables. A major current emphasis is on studying potential interactions between exposure to an infection or an autoimmune response and key early phases of brain development. A corresponding priority in the research agenda will be the development of animal models of CNS development that might elucidate the pathogenic mechanisms of such an interaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - infection
KW  - autoimmunity
KW  - etiologic factors
KW  - brain abnormalities
KW  - schizophrenia patients
KW  - environmental factors
KW  - genetic endowment
KW  - central nervous system
KW  - 1993
KW  - Brain
KW  - Etiology
KW  - Immunology
KW  - Infectious Disorders
KW  - Schizophrenia
KW  - Central Nervous System
KW  - Environmental Effects
KW  - Genetics
KW  - 1993
DO  - 10.1093/schbul/19.2.355
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09723-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09720-006
AN  - 2005-09720-006
AU  - Torrey, E. Fuller
AU  - Bowler, Ann E.
AU  - Rawlings, Robert
AU  - Terrazas, Alejandro
T1  - Seasonality of Schizophrenia and Stillbirths.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1993///
VL  - 19
IS  - 3
SP  - 557
EP  - 562
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Torrey, E. Fuller, Twin Study Unit, NIMH Neurosciences Ctr., St. Elizabeths Hospital, Washington, DC, US, 20032
N1  - Accession Number: 2005-09720-006. PMID: 8235458 Partial author list: First Author & Affiliation: Torrey, E. Fuller; Twin Study Unit, National Institute of Mental Health Neuroscience Center, St. Elizabeths Hospital, Washington, DC, US. Other Publishers: Oxford University Press. Release Date: 20060206. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Schizophrenia; Seasonal Variations. Minor Descriptor: Birth; Etiology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: 1993. 
AB  - A study of the birth pattern of 30,467 patients with schizophrenia and 428,406 stillbirths in New York State showed a significant winter-month excess in both schizophrenia births (p = 0.0000) and stillbirths (p = 0.0000). Excess births of individuals with schizophrenia in November and December provided additional evidence to refute the age-incidence explanation for the observed seasonality. Time series spectral analysis showed coherence in the pattern of schizophrenia births and stillbirths of 0.898 (p < 0.003) with schizophrenia births preceding stillbirths by 13 days. These results suggest that a common etiological seasonal factor affects a subgroup of births of individuals who later develop schizophrenia and a subgroup of stillbirths. Nutritional factors, temperature, and infectious agents known to cause both central nervous system disease and stillbirths are possible candidates. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - seasonality
KW  - stillbirths
KW  - etiology
KW  - 1993
KW  - Schizophrenia
KW  - Seasonal Variations
KW  - Birth
KW  - Etiology
KW  - 1993
DO  - 10.1093/schbul/19.3.557
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09720-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-26895-012
AN  - 2005-26895-012
AU  - Goldberg, Terry E.
AU  - Hyde, Thomas M.
AU  - Kleinman, Joel E.
AU  - Weinberger, Daniel R.
T1  - Course of Schizophrenia: Neuropsychological Evidence for a Static Encephalopathy.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1993///
VL  - 19
IS  - 4
SP  - 797
EP  - 804
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Goldberg, Terry E., Clinical Brain Disorders Branch, NIMH Neuroscience Center, St. Elizabeths Hospital, 2700 Martin Luther King, Jr., Ave., SE, Washington, DC, US, 20032
N1  - Accession Number: 2005-26895-012. PMID: 8303228 Partial author list: First Author & Affiliation: Goldberg, Terry E.; Unit on Neuropsychology, Clinical Brain Disorders Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Dementia; Encephalopathies; Neuropsychology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 8. Issue Publication Date: 1993. 
AB  - The course of cognitive function in schizophrenia has often been debated. In one view, it is thought to be akin to that of a progressive dementia with relentless cognitive decline. In another view, the deficits are thought to remain relatively stable, analogous to those of a static encephalopathy. Review of longitudinal and cross-sectional studies strongly supports the latter interpretation. In particular, we present data from a recent cross-sectional study in which cohorts of patients in their third, fourth, fifth, sixth, and seventh decades of life were administered a battery of tests known to be sensitive to progressive dementing diseases. All patients were carefully screened to exclude those with neurologic, systemic, or psychiatric comorbid conditions, and cohorts were matched on estimated premorbid intellectual capacity. Although scores on most tests were impaired, no evidence of decline across groups was observed. These results are also consistent with neuroimaging and neuropathological studies in that no evidence for an active degenerative process has been discovered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cognitive function
KW  - schizophrenia
KW  - neuropsychological evidence
KW  - static encephalopathy
KW  - dementia
KW  - 1993
KW  - Cognitive Ability
KW  - Dementia
KW  - Encephalopathies
KW  - Neuropsychology
KW  - Schizophrenia
KW  - 1993
DO  - 10.1093/schbul/19.4.797
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26895-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105851027
T1  - Immunotoxin therapy for cancer.
AU  - Pai LH
AU  - Pastan I
AU  - Pai, L H
AU  - Pastan, I
Y1  - 1993/01/06/
N1  - Accession Number: 105851027. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article; review. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Bacterial Toxins -- Therapeutic Use
KW  - Neoplasms -- Therapy
KW  - Toxins -- Therapeutic Use
KW  - Toxins
KW  - Transferases
KW  - Antibodies, Monoclonal
KW  - Bacterial Toxins
KW  - DNA, Recombinant
KW  - Drug Design
KW  - Forecasting
KW  - Pseudomonas
SP  - 78
EP  - 81
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 269
IS  - 1
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892
AD  - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892.
U2  - PMID: 8416411.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105851026
T1  - AIDS-associated primary central nervous system lymphoma. Oncology Core Committee, AIDS Clinical Trials Group.
AU  - Galetto G
AU  - Levine A
AU  - Galetto, G
AU  - Levine, A
Y1  - 1993/01/06/
N1  - Accession Number: 105851026. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Central Nervous System Neoplasms -- Therapy
KW  - Lymphoma, AIDS-Related -- Therapy
SP  - 92
EP  - 93
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 269
IS  - 1
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Md
AD  - Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Md.
U2  - PMID: 8416414.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105851026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104785572
T1  - Stability and prevalence of drinking among young adults.
AU  - Harford, T C
Y1  - 1993/02//
N1  - Accession Number: 104785572. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Adolescence
KW  - Adult
KW  - Age Factors
KW  - Female
KW  - Human
KW  - Prospective Studies
KW  - Male
KW  - Prevalence
KW  - Sex Factors
KW  - United States
SP  - 273
EP  - 277
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 2
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This data note draws upon the National Longitudinal Survey (NLS) of Labor Market Experience in Youth beginning at ages 17-24 to describe the stability and prevalence of alcohol use over a 6-year period up to ages 23-30. Approximately 70% of men and 58% of women maintained their drinking status throughout the study. The onset of current and heavier drinking decreased with increasing age while the offset of current and heavier drinking increased with increasing age. The absence of current drinking was unrelated to age for both men and women as was the presence of heavier drinking among men.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, Maryland 29857.
U2  - PMID: 8220065.
DO  - 10.1111/j.1360-0443.1993.tb00811.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Alger, Sharon
AU  - Larson, Karen
AU  - Boyce, Vicky L.
AU  - Seagle, Helen
AU  - Fontvieille, Anne-Marie
AU  - Ferraro, Robert T.
AU  - Rising, Russell
AU  - Ravussin, Eric
T1  - Effect of phenylpropanolamine on energy expenditure and weight loss in overweight women.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/02//
VL  - 57
IS  - 2
M3  - Article
SP  - 120
EP  - 126
SN  - 00029165
AB  - The effect of phenylpropanolamine (PPA), a noncatecholamine sympathomimetic weight-loss agent, on energy expenditure (EE) and substrate oxidation was measured in a respiratory chamber in 24 overweight women after 4 d of treatment (PPA or placebo) during weight maintenance and after 7 wk of treatment on a hypoenergetic diet (70% of measured baseline 24-h EE). Twelve women (37 ± 2 y, 74 ± 6 kg, 33 ± 1% body fat) were randomly assigned to the PPA group [75 mg osmotic release oral system (OROS)-PPA/d] and 12 (1 ± SEM: 38 ± 2 y, 79 ± 1 kg, 37 ± 1% body fat) to the placebo group. Baseline measurements of 24-h EE (7849 ± 226 vs 7834 ± 142 kJ/d), basal metabolic rate (BMR) and 24-h respiratory quotient (RQ) were comparable between PPA and placebo groups. After 4 d of treatment, there was no significant effect of PPA on 24h EE, BMR, and 24-h RQ compared with placebo. Over the 7wk diet period, however, the PPA group (n = 8) had greater weight loss than the placebo group (n 10): -5.0 ± 0.5 vs -3.0 ± 0.4 kg (P < 0.05). The changes in 24-h EE and 24-h RQ over the 7 wk were not different between the groups. We conclude that weight loss is enhanced by OROS-PPA, but this change was not explained by changes in 24-h EE or 24-h RQ. The small number of subjects may have hindered detection of subtle differences in energy metabolism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Phenylpropanolamine
KW  - Caloric expenditure
KW  - Weight loss
KW  - Overweight women
KW  - Catecholamines
KW  - Placebos (Medicine)
KW  - Basal metabolism
N1  - Accession Number: 94403620; Alger, Sharon 1,2; Larson, Karen 1,2; Boyce, Vicky L. 1,2; Seagle, Helen 1,2; Fontvieille, Anne-Marie 1,2; Ferraro, Robert T. 1,2; Rising, Russell 1,2; Ravussin, Eric 1,2; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ; 2: Division of Clinical Nutrition, Albany Medical Center, Albany, NY 12208; Issue Info: Feb1993, Vol. 57 Issue 2, p120; Subject Term: Phenylpropanolamine; Subject Term: Caloric expenditure; Subject Term: Weight loss; Subject Term: Overweight women; Subject Term: Catecholamines; Subject Term: Placebos (Medicine); Subject Term: Basal metabolism; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Biben, Maxeen
T1  - Recognition of Order Effects in Squirrel Monkey Antiphonal Call Sequences.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1993/02//
VL  - 29
IS  - 2
M3  - Article
SP  - 109
EP  - 124
SN  - 02752565
AB  - Squirrel monkeys exchange chuck vocalizations in antiphonal sequences that suggest a request for information, and a response to that request. Chucks are characterized by measurable acoustic differences, notably in peak frequency, related to their position in a sequent. To determine the cues by which animals might identify a chuck that is a request for information from one that is a response, first-in-sequence (alpha;) and second-insequence (beta;) chucks, differing in peak frequency, were recorded from familiar individuals and strangers. These chucks, and a sham control, were played back, in the temporal context of a first-in-sequence calk to a target group of socially housed captive squirrel monkeys. Animals responded more strongly to a chucks than to β chucks for calls originating from familiar individuals. No distinction was made between the a and β chucks of strangers, and all strangers' chucks got a weaker response than did familiar a chucks. Squirrel monkeys probably use acoustic differences, rather than context, to discriminate the ordinal significance of a chuck, but cannot do so unless they are familiar with the caller. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUIRREL monkeys
KW  - ANIMAL calls
KW  - ANIMAL communication
KW  - SOUND production by animals
KW  - ANIMAL sounds
KW  - BIOACOUSTICS
KW  - communication
KW  - Saimiri sciureus
KW  - squirrel monkey
N1  - Accession Number: 12350173; Biben, Maxeen 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland; Source Info: 1993, Vol. 29 Issue 2, p109; Subject Term: SQUIRREL monkeys; Subject Term: ANIMAL calls; Subject Term: ANIMAL communication; Subject Term: SOUND production by animals; Subject Term: ANIMAL sounds; Subject Term: BIOACOUSTICS; Author-Supplied Keyword: communication; Author-Supplied Keyword: Saimiri sciureus; Author-Supplied Keyword: squirrel monkey; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Windsor, Richard A.
AU  - Chang Qing Li
AU  - Lowe, John B.
AU  - Perkins, Laura L.
AU  - Ershoff, Dan
AU  - Glynn, Tom
T1  - The Dissemination of Smoking Cessation Methods for Pregnant Women: Achieving the Year 2000 Objectives.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/02//
VL  - 83
IS  - 2
M3  - Article
SP  - 173
EP  - 178
PB  - American Public Health Association
SN  - 00900036
AB  - The smoking prevalence rate among adult women and pregnant women has decreased only 0.3 to 0.5% per year since 1969. Without a nationwide dissemination of efficacious smoking cessation methods based on these trends, by the year 2000 the smoking prevalence among pregnant women will be approximately 18%. This estimate is well above the US Department of Health and Human Services Year 2000 Objective of 10%. The US dissemination of tested smoking cessation methods could help an additional 12 900 to 155 000 pregnant smokers annually and 600 000 to 1 481 000 cumulatively to quit smoking during the 1990s. Dissemination could help achieve 31 to 78% of the Year 2000 Objectives for pregnancy smoking prevalence. (With dissemination, at best a 15% smoking prevalence during pregnancy, rather than the 10% objective, is likely to be observed.) Our results confirm a well-documented need for a national campaign to disseminate smoking cessation methods. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SMOKING
KW  - PREGNANT women
KW  - WOMEN
KW  - SMOKING cessation
KW  - CIGARETTE smokers
N1  - Accession Number: 9307096187; Windsor, Richard A. 1 Chang Qing Li 2 Lowe, John B. 3 Perkins, Laura L. 4 Ershoff, Dan 5 Glynn, Tom 6; Affiliation:  1: National Heart, Lung, and Blood Institute, Bethesda, Md  2: School of Medicine, University of Alabama-Birmingham  3: Cancer Prevention Research Center, University of Queensland, Australia  4: School of Public Health, University of Alabama-Birmingham  5: Kaiser Permanente, Los Angeles, Calif  6: National Cancer Institute, Rockville, Md; Source Info: Feb1993, Vol. 83 Issue 2, p173; Subject Term: SMOKING; Subject Term: PREGNANT women; Subject Term: WOMEN; Subject Term: SMOKING cessation; Subject Term: CIGARETTE smokers; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Windsor, Richard A.
AU  - Lowe, John B.
AU  - Perkins, Laura L.
AU  - Smith-Yoder, Dianne
AU  - Artz, Lynn
AU  - Crawford, Myra
AU  - Amburgy, Kim
AU  - Boyd Jr., Neal Richard
T1  - Health Education for Pregnant Smokers: Its Behavioral Impact and Cost Benefit.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/02//
VL  - 83
IS  - 2
M3  - Article
SP  - 201
EP  - 206
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. A randomized trial (the Birmingham Trial II) was conducted to evaluate the behavioral impact of health education methods among 814 female smokers at four public health maternity clinics. Methods. Four hundred patients were randomly assigned to an Experimental (E) Group, and 414 were assigned to a Control (C) Group. Self-reports and saliva cotinine tests confirmed smoking status at the first visit, at midpregnancy, and at end of pregnancy. Results. The E Group exhibited a 14.3% quit rate and the C Group an 8.5% quit rate. A Historical Comparison (C) Groups exhibited a 3.0% quit rate. Black E and C Group patients had higher quit rates than White E and C Group patients. A cost-benefit analysis found cost-to-benefit ratios of $1:$6.72 (low estimate) and $1:$17.18 (high estimate) and an estimated savings of $247 296 (low estimate) and $699 240 (high estimate). Conclusion. Health education methods are efficacious and cost beneficial for pregnant smokers in public health maternity clinics. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH education
KW  - CIGARETTE smokers
KW  - CLINICS
KW  - PATIENTS
KW  - WOMEN
N1  - Accession Number: 9307096192; Windsor, Richard A. 1 Lowe, John B. 2 Perkins, Laura L. 1 Smith-Yoder, Dianne 3 Artz, Lynn 1 Crawford, Myra 4 Amburgy, Kim 5 Boyd Jr., Neal Richard 6; Affiliation:  1: School of Public Health, University of Alabama, Birmingham  2: Cancer Prevention Research Center, University of Queensland, Australia  3: Alabama Department of Public Health, Montgomery  4: School of Medicine, University of Alabama, Birmingham  5: State of Washington Department of Health, Olympia  6: National Cancer Institute, National Institutes of Health, Bethesda, Md; Source Info: Feb1993, Vol. 83 Issue 2, p201; Subject Term: HEALTH education; Subject Term: CIGARETTE smokers; Subject Term: CLINICS; Subject Term: PATIENTS; Subject Term: WOMEN; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621499 All other out-patient care centres; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jun Zhang
AU  - Ratcliffe, Jennifer M.
T1  - Paternal Smoking and Birthweight in Shanghai.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/02//
VL  - 83
IS  - 2
M3  - Article
SP  - 207
EP  - 210
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Although maternal active smoking has been established to be associated with fetal growth retardation, evidence of an effect of environmental tobacco smoke exposure on birthweigth is still limited and inconclusive. This study addressed the relationship between prenatal environmental tobacco smoke exposure and birthweigth and fetal growth retardation in Shanghai, China. Methods. Data on 1785 full-term live-born normal infants of nonsmoking mothers were used from the Shanghai Birth Defects and Perinatal Death Monitoring conducted between October 1986 and September 1987. Environmental tobacco smoke exposure was defined as exposure to paternal smoking. Results. Infants with environmental tobacco smoking exposure were, on average, 30g lower in birth weight than nonexposed infants, after adjustment for gestational age, parity, maternal age, and occupation. Conclusion. Consistent with previous research, this study suggest that environmental tobacco smoking exposure may have a modestly adverse effect on birthweight. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SMOKING
KW  - FETAL growth retardation
KW  - BIRTH weight
KW  - TOBACCO
KW  - MOTHERS
N1  - Accession Number: 9307096193; Jun Zhang 1 Ratcliffe, Jennifer M. 2; Affiliation:  1: Department of Epidemiology and Carolina Population Center, University of North Carolina, Chapel Hill  2: Epidemiology Branch, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC; Source Info: Feb1993, Vol. 83 Issue 2, p207; Subject Term: SMOKING; Subject Term: FETAL growth retardation; Subject Term: BIRTH weight; Subject Term: TOBACCO; Subject Term: MOTHERS; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simons-Morton, Bruce G.
AU  - Taylor, Wendell C.
AU  - Snider, Sharon A.
AU  - Huang, Iris W.
T1  - The Physical Activity of Fifth-Grade Students During Physical Education Classes.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/02//
VL  - 83
IS  - 2
M3  - Article
SP  - 262
EP  - 264
PB  - American Public Health Association
SN  - 00900036
AB  - One hundred fifty-seven fifth-grade students in 20 of the 355 elementary schools in one Texas county were systematically observed during physical education classes. On average, the students spent 8.5% of class time in moderate to vigorous physical activity, 23.3% in minimal activity, and 68.1% in sedentary activity. None of the schools averaged 20% of class time in moderate to vigorous physical activity. The levels of physical activity observed are substantially lower than the levels called for in national health objectives. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STUDENTS
KW  - ELEMENTARY schools
KW  - PHYSICAL education
KW  - CLASSES (Groups of students)
KW  - TEXAS
N1  - Accession Number: 9307096206; Simons-Morton, Bruce G. 1 Taylor, Wendell C. Snider, Sharon A. Huang, Iris W.; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, Md; Source Info: Feb1993, Vol. 83 Issue 2, p262; Subject Term: STUDENTS; Subject Term: ELEMENTARY schools; Subject Term: PHYSICAL education; Subject Term: CLASSES (Groups of students); Subject Term: TEXAS; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; NAICS/Industry Codes: 611620 Sports and Recreation Instruction; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Salive, Marcel E.
AU  - Guralnik, Jack M.
AU  - Glynn, Robert J.
T1  - Left-Handedness and Mortality.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/02//
VL  - 83
IS  - 2
M3  - Article
SP  - 265
EP  - 267
PB  - American Public Health Association
SN  - 00900036
AB  - We examined mortality associated with handedness in two ways. A simulation using national data suggest that lower mean age at death among left-handed persons, previously offered as evidence of higher mortality, can be explained exclusively by the age distribution of laterality. Second, empiric evidence from a 6-year cohort study of 3774 older adults from East Boston, Massachusetts, demonstrates that left handedness is not associated with mortality (relative odds) = 1.04, 95% confidence interval = 0.79, 1.36). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MORTALITY
KW  - HANDEDNESS
KW  - DEATH
KW  - AGE
KW  - AGE distribution (Demography)
N1  - Accession Number: 9307096207; Salive, Marcel E. 1 Guralnik, Jack M. 1 Glynn, Robert J. 2; Affiliation:  1: Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Md  2: Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Mass; Source Info: Feb1993, Vol. 83 Issue 2, p265; Subject Term: MORTALITY; Subject Term: HANDEDNESS; Subject Term: DEATH; Subject Term: AGE; Subject Term: AGE distribution (Demography); Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Steel, Elizabeth
AU  - Fleming, Patricia L.
AU  - Needle, Richard
T1  - The HIV Rates of Injection Drug Users in Less-Populated Areas.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/02//
VL  - 83
IS  - 2
M3  - Letter
SP  - 286
EP  - 287
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor about HIV seroprevalence rates in injection drug users entering drug treatment in the U.S. metropolitan areas is presented.
KW  - LETTERS to the editor
KW  - HIV (Viruses)
N1  - Accession Number: 20667870; Steel, Elizabeth 1 Fleming, Patricia L. 2 Needle, Richard 1; Affiliation:  1: National Institute on Drug Abuse, Rockville, Md  2: National Center for Infectious Diseases, Atlanta, Ga; Source Info: Feb1993, Vol. 83 Issue 2, p286; Subject Term: LETTERS to the editor; Subject Term: HIV (Viruses); Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sananayake, N.
AU  - Román, G. C.
T1  - Epidemiology of epilepsy in developing countries.
T2  - Epidémiologie de l'épilepsie dans les pays en développement.
JO  - Bulletin of the World Health Organization
JF  - Bulletin of the World Health Organization
Y1  - 1993/02//
VL  - 71
IS  - 2
M3  - Article
SP  - 247
EP  - 258
PB  - World Health Organization
SN  - 00429686
AB  - Epilepsy is an important health problem in developing countries, where its prevalence can be up to 57 per 1000 population. This article reviews the epidemiology of epilepsy in developing countries in terms of its incidence, prevalence, seizure type, mortality data, and etiological factors. The prevalence of epilepsy is particularly high in Latin America and in several African countries, notably Liberia, Nigeria, and the United Republic of Tanzania. Parasitic infections, particularly neurocysticercosis, are important etiological factors for epilepsy in many of these countries. Other reasons for the high prevalence include intracranial infections of bacterial or viral origin, perinatal brain damage, head injuries, toxic agents, and hereditary factors. Many of these factors are, however, preventable or modifiable, and the introduction of appropriate measures to achieve this could lead to a substantial decrease in the incidence of epilepsy in developing countries. (English) [ABSTRACT FROM AUTHOR]
AB  - L'épilepsie constitue un problème de santé important dans les pays en développement, où elle est à l'origine d'une morbidité élevée et de conséquences potentiellement graves. Sa prévalence est extrêmement variable, allant de 1,3 à 57 pour 1000 habitants. Cette prévalence est généralement faible dans les régions du nord de l'lnde et éleveé dans plusieurs pays africains, notamment au Libéria (28/1000, 49/1000), au Nigéria (37/1000) et en République-Unie de Tanzanie (20/1000), ainsi qu'en Amérique latine -- Colombie (17/1000 et 19,5/1000), Equateur (17/1000), Panama (22/1000 et 57/1000) et Venezuela (4,1 à 22,6/1000). La plupart des études rapportent un pourcentage plus élevé de crises d'épilepsie partielle, probablement en raison de la forte incidence de l'épilepsie symptomatique provoquée par des facteurs secondaires. A cet égard, les infestations parasitaires et en particulier la cysticercose, en sont l'une des principales causes. Au Mexique, la cysticercose est à l'origjne de la moitié des cas d'épilepsie d'installation tardive et en Equateur, d'un quart de tous les nouveaux cas. Au Brésil, c'est la cause d'epilepsie la plus facile à identifier. D'autres infections, telles que la méningite tuberculeuse et les abcès cérébraux sont également des facteurs déclenchants importants. Dans de nombreux pays en développement, une forte proportion des accouchements a lieu à domicile, sans l'aide d'une sage-femme qualifiée. Dans certaines régions, les proportions de grossesses multiples et d'accouchements avant terme sont élevées. De nombreuses mères sont également multipares, malnutries, anémiées et exposées à toutes sortes d'infections pouvant toucher leurs enfants in utero. L'ictère nucléaire provoqué par un déficit en glucose-6-phosphate-déshydrogénase pose des problèmes particuliers dans certaines régions. Tous ces facteurs peuvent entraîner des lésions cérébrales dans la période périnatale et donc une épilepsie. En raison de la fréquence élevée des maladies fébriles, l'incidence des convulsions fébriles est élevée sous les tropiques; ces dernières peuvent être associées par la suite à un risque six fois plus élevé d'épilepsie. Les traumatismes crâniens dus à des agressions, à des accidents de la circulation, ou à des chutes sont une autre cause importante d'épilepsie dans les pays en développement. Le potentiel neurotoxique de certains remédes préparés à domicile et les poisons présents dans l'environnement tels que le plomb et les insecticides doivent également être pris en compte. Dans de nombreux pays, la consanguinité relativement fréquente et la stigmatisation associée à l'épilepsie peuvent empêcher ceux qui en souffrent de trouver un conjoint dans des families en bonne santé; il peut s'ensuivre un risque augmenté de troubles comitiaux dans leur descendance. Les facteurs étiologiques potentiels de l'épilepsie dans les pays en développement sont nombreux, même si beaucoup d'entre eux sont évitables. Une détection précoce et un traitement adéquat peuvent réduire le risque d'épilepsie et les autres séquelles à long terme des infections intracrâniennes.… (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epidemiology
KW  - Epilepsy
KW  - Spasms
KW  - Developing countries
KW  - Brain diseases
KW  - Neurocysticercosis in children
N1  - Accession Number: 24755897; Sananayake, N. 1,2; Román, G. C. 3; Affiliations: 1: Visiting Scientist, Neuroepiderniology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA,; 2: Professor of Medicine, University of Peradeniya, Peradeniya, Sri Lanka; 3: Chief, Neuroepidemiology Branch, NINDS, National Institutes of Health, Bethesda, Maryland, USA; Issue Info: 1993, Vol. 71 Issue 2, p247; Thesaurus Term: Epidemiology; Subject Term: Epilepsy; Subject Term: Spasms; Subject Term: Developing countries; Subject Term: Brain diseases; Subject Term: Neurocysticercosis in children; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Sandrock, Dirk
AU  - Lastoria, Secondo
AU  - Magrath, Ian
AU  - Neumann, Ronald
T1  - The role of gallium-67 tumour scintigraphy in patients with small, non-cleaved cell lymphoma.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1993/02//
VL  - 20
IS  - 2
M3  - Article
SP  - 119
EP  - 122
SN  - 03406997
N1  - Accession Number: 71145224; Sandrock, Dirk 1 Lastoria, Secondo 1 Magrath, Ian 2 Neumann, Ronald 1; Affiliation:  1: Department of Nuclear Medicine, National Cancer Institute, National Institutes of Health, Bethesda USA  2: Pediatric Branch, Department of Clinical Investigations, National Cancer Institute, National Institutes of Health, Bethesda USA; Source Info: Feb1993, Vol. 20 Issue 2, p119; Number of Pages: 4p; Document Type: Article
L3  - 10.1007/BF00168871
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kameyama, Koichiro
AU  - Takemura, Toshiyuki
AU  - Hamada, Yuko
AU  - Sakai, Clue
AU  - Kondoh, Shigeo
AU  - Nishiyama, Shigeo
AU  - Urabe, Kazunori
AU  - Hearing, Vincent J.
T1  - Pigment Production in Murine Melanoma Cells Is Regulated by Tyrosinase, Tyrosinase-Related Protein 1 (TRP1), DOPAchrome Tautomerase (TRP2), and a Melanogenic Inhibitor.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/02//
VL  - 100
IS  - 2
M3  - Article
SP  - 126
EP  - 131
SN  - 0022202X
AB  - Using antibodies that recognize either tyrosinase, tyrosinase-related protein-1 (TRP1), or tyrosinase-related protein-2 (TRP2, DOPAchrome tautomerase), the quantities of those melanogenic enzymes were analyzed in five melanoma cell lines that possess various degrees of melanin production. All cells except JB/MS-W increased melanin production four to 30 times after 4 d of melanocyte-stimulating hormone (MSH) treatment. Melanin production by JB/MS-W cells 'was always under background, with Or without MSH treatment. There was a positive correlation between quantities and synthetic rates of those melanogenic enzymes and their melanin formation or DOPAchrome tautomerase activities. The activity of a heat-resistant melanogenic inhibitory factor was also analyzed. The results showed, surprisingly, that pigmented cells showed higher levels of melanogenic inhibitors activity. Tyrosinase activity was increased dramatically whereas the level of melanogenic inhibitor was remarkably decreased following MSH treatment. Interestingly, melanogenic inhibitor derived from JB/MS-W cells suppressed not only tyrosinase but also DOPAchrome tautomerase, another enzyme functional in melanin production. These results clearly suggest that melanin production is regulated by a subtle balance between the activities of these enzymes and other factors such as the melanogenic inhibitor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOMA
KW  - CANCER
KW  - PROTEINS
KW  - CELLS
KW  - BIOLOGY
KW  - PHENOL oxidase
N1  - Accession Number: 12462778; Kameyama, Koichiro 1 Takemura, Toshiyuki 1 Hamada, Yuko 1 Sakai, Clue 1 Kondoh, Shigeo 1 Nishiyama, Shigeo 1 Urabe, Kazunori 2 Hearing, Vincent J. 2; Affiliation:  1: Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan  2: Laboratory of Cell Biology, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb93, Vol. 100 Issue 2, p126; Subject Term: MELANOMA; Subject Term: CANCER; Subject Term: PROTEINS; Subject Term: CELLS; Subject Term: BIOLOGY; Subject Term: PHENOL oxidase; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12462778
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - patterson, Gregory M. L.
AU  - Baker, Kathleen K.
AU  - Baldwin, Cynthia L.
AU  - Bolis, Christine M.
AU  - Caplan, Faith R.
AU  - Larsen, Linda K.
AU  - Levine, Ira A.
AU  - Moore, Richard E.
AU  - Nelson, Carrie S.
AU  - Tschappat, Kathryn D.
AU  - Tuang, Grace D.
AU  - Boyd, Michael R.
AU  - Cardellina II, John H.
AU  - Collins, Ralph P.
AU  - Gustafson, Kirk R.
AU  - Snader, Kenneth M.
AU  - Weislow, Owen S.
AU  - Lewin, Ralph A.
T1  - ANTIVIRAL ACTIVITY OF CULTURED BLUE-GREEN ALGAE (CYANOPHYTA).
JO  - Journal of Phycology
JF  - Journal of Phycology
Y1  - 1993/02//
VL  - 29
IS  - 1
M3  - Article
SP  - 125
EP  - 130
PB  - Wiley-Blackwell
SN  - 00223646
AB  - Lipophilic and hydrophilic extracts from approximately 600 strains of cultured cyanophytes, representing some 300 species, were examined for antiviral activity against three pathogenic viruses. Approximately 10% of the cultures produced substances that caused significant reduction in cytopathic effect normally associated with viral infection. The screening program identified the order Chroococcales as commonly producing antiviral agents. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cyanobacteria
KW  - HIV (Viruses)
KW  - Drugs
KW  - Herpesviruses
KW  - antiviral
KW  - cyanobacteria
KW  - cyanophyte
KW  - herpes virus: HIV-1
KW  - HSV-2
KW  - human immunodeficiency virus
KW  - natural products
KW  - pharmaceutical
KW  - respiratory syncytial virus.
N1  - Accession Number: 11557880; patterson, Gregory M. L. 1; Baker, Kathleen K. 1; Baldwin, Cynthia L. 1; Bolis, Christine M. 1; Caplan, Faith R. 1; Larsen, Linda K. 1; Levine, Ira A. 1; Moore, Richard E. 1; Nelson, Carrie S. 1; Tschappat, Kathryn D. 1; Tuang, Grace D. 1; Boyd, Michael R. 2; Cardellina II, John H. 2; Collins, Ralph P. 2; Gustafson, Kirk R. 2; Snader, Kenneth M. 2; Weislow, Owen S. 3; Lewin, Ralph A. 4; Affiliations: 1: Department of Chemistry, University of Hawaii, Honolulu, Hawaii 96822.; 2: Developmental Therapeutics Program, division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892.; 3: Program Resources, Inc., DynCorp, NCI-FCRF, Frederick, Maryland 21702.; 4: Scripps Institution of Oceanography, La Jolla, California 92093.; Issue Info: Feb93, Vol. 29 Issue 1, p125; Thesaurus Term: Cyanobacteria; Thesaurus Term: HIV (Viruses); Thesaurus Term: Drugs; Subject Term: Herpesviruses; Author-Supplied Keyword: antiviral; Author-Supplied Keyword: cyanobacteria; Author-Supplied Keyword: cyanophyte; Author-Supplied Keyword: herpes virus: HIV-1; Author-Supplied Keyword: HSV-2; Author-Supplied Keyword: human immunodeficiency virus; Author-Supplied Keyword: natural products; Author-Supplied Keyword: pharmaceutical; Author-Supplied Keyword: respiratory syncytial virus.; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1529-8817.ep11557880
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11557880&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Tilly, Kit
AU  - Hauser, Robyn
AU  - Campbell, Jim
AU  - Ostheimer, Gerard J.
T1  - Isolation of <em>dnaJ, dnaK</em>, and <em>grpE</em> homologues from <em>Borrelia burgdorferi</em> and complementation of <em>Escherichia coli</em> mutants.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/02//
VL  - 7
IS  - 3
M3  - Article
SP  - 359
EP  - 369
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The heat-shock proteins DnaJ, DnaK, and GrpE are involved in the replication of various species of DNA in <em>Escherichia coli</em>, in addition to their roles in other processes, including protein disaggregation and export. We have cloned the <em>Borrelia burgdorferi</em> homologues of these genes. DNA sequence analysis revealed an open reading frame encoding a protein that is 62% identical to the <em>E. coli</em> DnaK protein. Genes homologous to the <em>E. coli grpE</em> and <em>dnaJ</em> genes, encoding products 28% and 39% identical to their homologues, are located up- and downstream, respectively, of the <em>B. burgdorferi dnaK</em> gene. No obvious promoters were detected in the sequenced DNA, although a potential transcription terminator was found downstream of the <em>dnaJ</em> gene, so these three genes may form an operon, perhaps with a fourth gene located upstream of the <em>grpE</em> gene. The <em>grpE</em> homologue complemented an <em>E. coli grpE</em> mutant and the <em>dnaJ</em> homologue complemented an <em>E. coli dnaJ</em> mutant, whereas the <em>B. burgdorferi dnaK</em> gene did not complement <em>dnaK</em> mutants. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - DNA
KW  - Proteins
KW  - Borrelia burgdorferi
KW  - Genes
N1  - Accession Number: 15905237; Tilly, Kit 1; Hauser, Robyn 1,2; Campbell, Jim 1; Ostheimer, Gerard J. 1,2; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; 2: College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA; Issue Info: Feb1993, Vol. 7 Issue 3, p359; Thesaurus Term: Escherichia coli; Subject Term: DNA; Subject Term: Proteins; Subject Term: Borrelia burgdorferi; Subject Term: Genes; Number of Pages: 11p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06469-034
AN  - 2006-06469-034
AU  - Krasnegor, Norman A.
T1  - Biological Underpinnings of Developmental Disabilities.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1993/02//
VL  - 38
IS  - 2
SP  - 167
EP  - 168
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06469-034. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Krasnegor, Norman A.; Human Learning and Behavior Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavior Disorders; Developmental Disabilities; Etiology; Neurobiology. Minor Descriptor: Mental Disorders. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Rutter, Michael (Ed); Casaer, Paul (Ed). Biological Risk Factors for Psychosocial Disorders=Cambridge, England: Cambridge University Press, 1991. 346 pp. $64.95; 1991. Page Count: 2. Issue Publication Date: Feb, 1993. 
AB  - Reviews the book, Biological Risk Factors for Psychosocial Disorders by Michael Rutter and Paul Casaer (Eds.) (1991). The volume edited by Michael Rutter and Paul Casaer addresses state-of-the-art knowledge relating biological mechanisms to developmental disorders associated with behavioral disabilities. The editors have adopted an interdisciplinary strategy that includes contributions from basic and clinical researchers with multiple specialties in the biological and behavioral sciences. The book provides an excellent overview of the timetables for brain subsystem ontogeny and links these to a rationale for when, during development, damage to substrates will likely be manifest as behavioral deficits. Also useful are the chapters that elucidate molecular biological and behavior genetic approaches for asking and answering questions concerning the biological etiology of the behavioral disorders discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - biological risk factors
KW  - behavioral disorders
KW  - developmental disabilities
KW  - psychosocial disorders
KW  - 1993
KW  - Behavior Disorders
KW  - Developmental Disabilities
KW  - Etiology
KW  - Neurobiology
KW  - Mental Disorders
KW  - 1993
U2  - Rutter, Michael (Ed); Casaer, Paul (Ed). (1991); Biological Risk Factors for Psychosocial Disorders; Cambridge, England: Cambridge University Press, 1991. 346 pp. $64.95; 0-521-40103-8.
DO  - 10.1037/033044
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Pantaleo, Giuseppe
AU  - Graziosi, Cecilia
AU  - Fauci, Anthony S.
AU  - Pantaleo, G
AU  - Graziosi, C
AU  - Fauci, A S
T1  - The immunopathogenesis of human immunodeficiency virus infection.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1993/02/04/
VL  - 328
IS  - 5
M3  - journal article
SP  - 327
EP  - 335
SN  - 00284793
AB  - Outlines the available knowledge concerning the pathogenesis of HIV infection and discusses information that has recently emerged in this area. The course of HIV infection; Acute HIV syndrome; Clinical latency; Autoimmune mechanisms; HIV-specific immune responses; Apoptosis; More.
KW  - AIDS (Disease)
KW  - PHYSIOLOGICAL aspects
N1  - Accession Number: 24916075; Pantaleo, Giuseppe Graziosi, Cecilia Fauci, Anthony S. Pantaleo, G 1 Graziosi, C Fauci, A S; Affiliation:  1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 2/4/93, Vol. 328 Issue 5, p327; Subject Term: AIDS (Disease); Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 9p; Document Type: journal article; Full Text Word Count: 6743
L3  - 10.1056/NEJM199302043280508
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24916075&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 24916075
T1  - The immunopathogenesis of human immunodeficiency virus infection.
AU  - Pantaleo, Giuseppe
AU  - Graziosi, Cecilia
AU  - Fauci, Anthony S.
AU  - Pantaleo, G
AU  - Graziosi, C
AU  - Fauci, A S
Y1  - 1993/02/04/
N1  - Accession Number: 24916075. Language: English. Entry Date: In Process. Revision Date: 20170228. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). NLM UID: 0255562. 
KW  - HIV Infections -- Immunology
KW  - Human Immunodeficiency Virus -- Immunology
KW  - HIV Infections -- Etiology
KW  - Lymphoid Tissue -- Immunology
KW  - T Lymphocytes -- Immunology
KW  - Immunity
KW  - Apoptosis
KW  - Human Immunodeficiency Virus
KW  - Scales
SP  - 327
EP  - 335
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 328
IS  - 5
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - Outlines the available knowledge concerning the pathogenesis of HIV infection and discusses information that has recently emerged in this area. The course of HIV infection; Acute HIV syndrome; Clinical latency; Autoimmune mechanisms; HIV-specific immune responses; Apoptosis; More.
SN  - 0028-4793
AD  - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 8093551.
DO  - 10.1056/NEJM199302043280508
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wisniewski, Jan
AU  - Malezewski, Marck
AU  - Krawczyk, Zdzislaw
AU  - Gedamu, Lashitew
T1  - An upstream region of the rat spermatogenesis-specific heat-shock-like Hst70 gene confers testis-specific expression in transgenic mice.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1993/02/15/
VL  - 212
IS  - 1
M3  - Article
SP  - 137
EP  - 143
PB  - Wiley-Blackwell
SN  - 00142956
AB  - In order to study the temporal and spatial regulation of a rat testis-specific heat-shock-like hst70 gene, an 0.8-kb fragment of its upstream DNA was fused to the lacZ gene and microinjected into one-cell murine embryos. Independent tgHST1 and tgHST2 transgenic mice strains were established, containing about 5-7 and 40-60 transgene copies/haploid genome, respectively. Enzyme assays in various tissues showed that transgene-encoded β-galactosidase accumulates exclusively in testes of transgenic animals and cannot be detected until 16-17 days after birth. In-situ assays revealed that the enzyme accumulates mainly in pachytene primary spermatocytes. Our data complement previous studies on the endogenous rat hst70 and suggest that its 0.8-kb upstream region contains sufficient information to function as an active spermatogenesis-specific promoter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SPERMATOGENESIS in animals
KW  - GENE mapping
KW  - TRANSGENIC mice
KW  - ANIMAL genetic engineering
KW  - GAMETOGENESIS
KW  - MICE as laboratory animals
N1  - Accession Number: 12124048; Wisniewski, Jan 1,2,3 Malezewski, Marck 4 Krawczyk, Zdzislaw 1 Gedamu, Lashitew 3; Affiliation:  1: Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.  2: Laboratory of Biochemistry, National Cancer institute, Bethesda. USA.  3: Department of Biological Sciences, University of Calgary, Alberta, Canada.  4: Department of Embryology, Institute of ZooIogy, Warsaw University, Poland.; Source Info: 2/15/93, Vol. 212 Issue 1, p137; Subject Term: SPERMATOGENESIS in animals; Subject Term: GENE mapping; Subject Term: TRANSGENIC mice; Subject Term: ANIMAL genetic engineering; Subject Term: GAMETOGENESIS; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104788286
T1  - ICD-10 harmful use of alcohol and the alcohol dependence syndrome: prevalence and implications.
AU  - Grant, B F
Y1  - 1993/03//
N1  - Accession Number: 104788286. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Alcoholism -- Epidemiology
KW  - Psychological Tests -- Statistics and Numerical Data
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Alcohol Drinking
KW  - Alcoholism -- Diagnosis
KW  - Alcoholism -- Psychosocial Factors
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Incidence
KW  - Male
KW  - Middle Age
KW  - Psychometrics
KW  - United States
SP  - 413
EP  - 420
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Data from a 1988 survey on United States drinking practices and related problems was used to derive the prevalence and population estimates of harmful use of alcohol and the alcohol dependence syndrome as defined in the ICD-10 Clinical Descriptions and Diagnostic Guidelines Version (ICD-10-CDDG). Corresponding estimates were also presented for ICD-10-CDDG diagnoses that incorporated the duration criterion of the ICD-10-Diagnostic Criteria for Research Version (ICD-10-DCR). The prevalence of ICD-10 harmful use and dependence combined, with and without the duration criterion, were 5.2% and 7.1%, respectively. Corresponding harmful use rates were negligible (0.27%). Implications of the extremely low prevalence of harmful use in the US population and the impact of the duration criterion on the rates are discussed in terms of the fundamental nature of alcohol use disorders as syndromes and the viability of the harmful use of alcohol category as originally conceptualized.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, MD 20857.
U2  - PMID: 8461858.
DO  - 10.1111/j.1360-0443.1993.tb00829.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kant, Ashima K.
AU  - Schatzkin, Arthur
AU  - Harris, Tamara B.
AU  - Ziegler, Regina G.
AU  - Block, Gladys
T1  - Dietary diversity and subsequent mortality in the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/03//
VL  - 57
IS  - 3
M3  - Article
SP  - 434
EP  - 440
SN  - 00029165
AB  - We examined the relation of dietary diversity to subsequent all-cause mortality by using data from the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study, 1982-1987. The analytic cohort consisted of 4 160 men and 6264 women (including 2556 deaths), 25-74 y at baseline (1971-1975). Twenty-four-hour dietary recalls were evaluated for variety among the five major food groups: dairy. meat, grain, fruit, and vegetable, with a dietary diversity score (DDS): consumption of each food group contributed 1 point to a maximum possible DDS of 5. Age-adjusted risk of mortality was inversely related to DDS (P ≤ 0.0009) in men and women. The inverse diversity-mortality association was adjusted for potential confounders: education, race, smoking status, and dietary fiber intake; the relative risk of mortality in men and women consuming two or fewer food groups was 1.5 (95% CI 1.2 - 1.8) and 1.4 (95% CI 1.1 - 1.9), respectively. In conclusion, diets that omitted several food groups were associated with an increased risk of mortality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epidemiology -- Research
KW  - Nutrition surveys
KW  - Dairy products
KW  - Vegetables -- Composition
KW  - Smoking -- Health aspects
KW  - Mortality -- Risk factors
KW  - Diet and all-cause mortality
KW  - diet quality and mortality
KW  - dietary diversity
KW  - First National Health and Nutrition Examination Survey
KW  - mortality
KW  - NHANES I Epidemiologic Follow-up Study
N1  - Accession Number: 94403658; Kant, Ashima K. 1,2,3,4; Schatzkin, Arthur 1,2,3,4; Harris, Tamara B. 1,2,3,4; Ziegler, Regina G. 1,2,3,4; Block, Gladys 1,2,3,4; Affiliations: 1: City University of New York, Queens College, Flushing; 2: National Cancer Institute, Bethesda, MD; 3: National Institute on Aging, Bethesda, MD; 4: University of California, Berkeley; Issue Info: Mar1993, Vol. 57 Issue 3, p434; Thesaurus Term: Epidemiology -- Research; Subject Term: Nutrition surveys; Subject Term: Dairy products; Subject Term: Vegetables -- Composition; Subject Term: Smoking -- Health aspects; Subject Term: Mortality -- Risk factors; Author-Supplied Keyword: Diet and all-cause mortality; Author-Supplied Keyword: diet quality and mortality; Author-Supplied Keyword: dietary diversity; Author-Supplied Keyword: First National Health and Nutrition Examination Survey; Author-Supplied Keyword: mortality; Author-Supplied Keyword: NHANES I Epidemiologic Follow-up Study; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - McAuliffe, William E.
AU  - Ashery, Rebecca Sager
T1  - Implementation Issues and Techniques in Randomized Trials of Outpatient Psychosocial Treatments for Drug Abusers. II. Clinical and Administrative Issues.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1993/03//
VL  - 19
IS  - 1
M3  - Article
SP  - 35
EP  - 50
SN  - 00952990
AB  - This paper focuses on implementation problems in randomized trials of outpatient psychosocial treatments for drug abusers. The authors examined these problems in nine clinical trial studies and drew on published literature and their own research experiences. Common problems faced by principal investigators include the need for midstream treatment protocol and research design modifications based on the response of both clients and clinical staff, tension between research and clinical requirements, and the need to administer a large, complex organization over a substantial period of time. Solutions include conducting a pilot study, employing advanced research and analysis methods that can incorporate complex design variations, fostering a team spirit between diverse staffs, and employing special management structures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MANAGEMENT science
KW  - CLINICAL medicine
KW  - INTERORGANIZATIONAL relations
KW  - ORGANIZATIONAL sociology
KW  - MEDICAL research
KW  - MEDICAL model
N1  - Accession Number: 9409010031; McAuliffe, William E. 1 Ashery, Rebecca Sager 2; Affiliation:  1: Department of Psychiatry, Harvard Medical School, Cambridge Hospital 1493 Cambridge Street, Cambridge, Massachusetts.  2: Community Research Branch, National Institute on Drug Abuse, 5600 Fishers Lane, Room 9A-30, Rockville, Maryland 20857.; Source Info: 1993, Vol. 19 Issue 1, p35; Subject Term: MANAGEMENT science; Subject Term: CLINICAL medicine; Subject Term: INTERORGANIZATIONAL relations; Subject Term: ORGANIZATIONAL sociology; Subject Term: MEDICAL research; Subject Term: MEDICAL model; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 16p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Karhumäki, E.
AU  - Viljanen, M. E.
AU  - Cottler-Fox, M.
AU  - Ranki, A.
AU  - Fox, C. H.
AU  - Krohn, K . J . E.
T1  - An improved enrichment method for functionally competent, highly purified peripheral blood dendritic cells and its application to HIV-infected blood samples.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1993/03//
VL  - 91
IS  - 3
M3  - Article
SP  - 482
EP  - 488
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Dendritic cells (DC) were purified from human peripheral blood using a rapid and simple method based on magnetic depletion of phagocytes with carbonyl iron, followed by centrifugation of  nonphagocytic cells on a Percoll density gradient and depletion of lymphocytes and macrophages/monocytes with a panel of MoAbs and immunomagnetic beads. Enriched DC were obtained with < 99% purity as judged by non-specific esterase (NSE) staining. After isolation, these cells, representing 0.4% of the starting mononuclear cell population, still function as potent antigen-presenting cells for purified T lymphocytes. The present results confirm the ability of human peripheral blood DC lo present soluble antigens to T cells including microbial antigens and show, further, that DC arc more potent soluble antigen-presenting cells than monocytes. The method was successfully applied to the purification of DC from the blood or HIV-infected individuals. We could not detect decreased numbers of DC in four individuals with early HIV infection and no replicating HIV was detected by in situ hybridization in the DC. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENDRITIC cells
KW  - HIV (Viruses)
KW  - LYMPHOCYTES
KW  - MACROPHAGES
KW  - MONOCYTES
KW  - ANTIGENS
KW  - antigen presentation
KW  - dendritic cells
KW  - HIV
N1  - Accession Number: 16444025; Karhumäki, E. 1 Viljanen, M. E. 1,2 Cottler-Fox, M. 3 Ranki, A. 4 Fox, C. H. 2 Krohn, K . J . E. 1; Affiliation:  1: Institute of Biomedical Sciences, Department of Pathology, University of Tampere, Tampere, Finland.  2: National Institutes of Health/National Institutes of Allergy and Infectious Diseases and  3: Department of Transfusion Medicine, Clinical Centre, National Institutes of Health, Bethesda, MD, USA.  4: Department of Dermatology and Venereology, Helsinki, University Central Hospital, Helsinki, Finland.; Source Info: Mar1993, Vol. 91 Issue 3, p482; Subject Term: DENDRITIC cells; Subject Term: HIV (Viruses); Subject Term: LYMPHOCYTES; Subject Term: MACROPHAGES; Subject Term: MONOCYTES; Subject Term: ANTIGENS; Author-Supplied Keyword: antigen presentation; Author-Supplied Keyword: dendritic cells; Author-Supplied Keyword: HIV; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Spitzer, Robert L.
AU  - Yanovski, Susan
AU  - Wadden, Thomas
AU  - Wing, Rena
AU  - Marcus, Marsha D.
AU  - Stunkard, Albert
AU  - Devlin, Michael
AU  - Mitchell, James
AU  - Hasin, Deborah
AU  - Horne, R. Lynn
T1  - Binge Eating Disorder: Its Further Validation in a Multisite Study.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993/03//
VL  - 13
IS  - 2
M3  - Article
SP  - 137
EP  - 153
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Binge eating (BED) is a new eating disorder that describes the eating disturbance of a large number of individuals who suffer from recurrent binge eating but who do not regularly engage in the compensatory behaviors to avoid weight gain seen in bulimia nervosa. This multistate study of BED involved 1,785 subjects drawn from 18 weight control programs, 942 subjects from five nonpatient community samples, and 75 patients with bulimia nervosa. Approximately 29% of subjects in weight control programs met the criteria for BED. In the nonpatient community samples BED was more common than purging bulimia nervosa. The validity of BED was supported by its strong association with (1) impairment in work and social functioning, (2) overconcern with body/shape and weight, (3) general psychopathology, (4) significant amount of time in adult life on diets, (5) a history of depression, alcohol/drug abuse, and treatment for emotional problems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPULSIVE eating
KW  - EATING disorders
KW  - WEIGHT loss
KW  - BULIMIA
KW  - WEIGHT gain
KW  - SOCIAL skills
KW  - BODY weight
KW  - PATIENTS
KW  - PATHOLOGICAL psychology
KW  - MENTAL depression
N1  - Accession Number: 11927249; Spitzer, Robert L. 1 Yanovski, Susan 2 Wadden, Thomas 3 Wing, Rena 4 Marcus, Marsha D. 5 Stunkard, Albert 6 Devlin, Michael 7 Mitchell, James 8 Hasin, Deborah 9 Horne, R. Lynn 10; Affiliation:  1: Professor of Psychiatry, Department of Psychiatry, Columbia University  2: Research Associate, Clinical Neuroendocrinology Branch, National Institute of Mental Health  3: Professor of Psychology, Syracuse University  4: Professor of Psychiatry, Psychology, and Epidemiology, University of Pittsburgh School of Medicine  5: Assistant Professor of Psychiatry and Psychology, University of Pittsburgh School of Medicine  6: Professor of Psychiatry, University of Pennsylvania  7: Assistant Clinical Professor of Psychiatry, Department of Psychiatry, Columbia University  8: Professor of Psychiatry, Department of Psychiatry, University of Minnesota  9: Associate Professor of Psychiatry and Public Health, Columbia Unviersity  10: Clinical Associate Professor, University of Nevada School of Medicine; Source Info: Mar1993, Vol. 13 Issue 2, p137; Subject Term: COMPULSIVE eating; Subject Term: EATING disorders; Subject Term: WEIGHT loss; Subject Term: BULIMIA; Subject Term: WEIGHT gain; Subject Term: SOCIAL skills; Subject Term: BODY weight; Subject Term: PATIENTS; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL depression; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Spitzer, Robert L.
AU  - Stunkard, Albert
AU  - Yanovski, Susan
AU  - Marcus, Marsha D.
AU  - Wadden, Thomas
AU  - Weng, Rene
AU  - Mitchell, James
AU  - Hasin, Deborah
T1  - Binge Eating Disorder Should Be Included in DSM-IV: A Reply to Fairburn et al.'s "The Classification of Recurrent Overeating: The Binge Eating Disorder Proposal".
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993/03//
VL  - 13
IS  - 2
M3  - Article
SP  - 161
EP  - 169
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Extensive recent research supports a proposal that a new eating disorder, binge eating disorder (BED), be included in DSM-IV. BED criteria define a relatively pure group of individuals who are distressed by recurrent binge eating who do not exhibit the compensatory features of bulimia nervosa. This large number of patients currently can only be diagnosed as eating disorder not otherwise specified (EDNOS). Recognizing this new disorder will help stimulate research and clinical programs for these patients. Fairburn et al.'s critique of BED fails to acknowledge the large body of knowledge that indicates that BED represents a distinct and definable subgroup of eating disordered patients and that the diagnosis provides useful information about psychopathology, prognosis, and outcome (Fairburn, Welch, & Hay [in press]). The classification of recurrent overeating: The ‘binge eating disorder’ proposal. International Journal of Eating Disorders.) Against any reasonable standard for adding a new diagnosis to DSM-IV, BED meets the test. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPULSIVE eating
KW  - EATING disorders
KW  - BULIMIA
KW  - DIAGNOSIS
KW  - MEDICAL research
KW  - RESEARCH
KW  - PATHOLOGICAL psychology
KW  - PROGNOSIS
KW  - DISTRESS (Psychology)
KW  - MEDICAL care
KW  - OUTCOME assessment (Medical care)
KW  - PATIENTS
N1  - Accession Number: 11927273; Spitzer, Robert L. 1 Stunkard, Albert 2 Yanovski, Susan 3 Marcus, Marsha D. 4 Wadden, Thomas 5 Weng, Rene 6 Mitchell, James 7 Hasin, Deborah; Affiliation:  1: Professor of Psychiatry, Columbia University  2: Professor of Psychiatry, University of Pennsylvania  3: Research Associate, Clinical Neuroendocrinology Branch, National Institute of Mental Health  4: Assistant Professor of Psychiatry and Psychology, University of Pittsburgh, School of Medicine  5: Professor of Psychology, Syracuse University  6: Professor of Psychiatry, Psycholgoy, and Epidemiology, University of Pittsburgh School of Medicine  7: Associate Professor of Psychiatry and Public Health, Columbia University; Source Info: Mar1993, Vol. 13 Issue 2, p161; Subject Term: COMPULSIVE eating; Subject Term: EATING disorders; Subject Term: BULIMIA; Subject Term: DIAGNOSIS; Subject Term: MEDICAL research; Subject Term: RESEARCH; Subject Term: PATHOLOGICAL psychology; Subject Term: PROGNOSIS; Subject Term: DISTRESS (Psychology); Subject Term: MEDICAL care; Subject Term: OUTCOME assessment (Medical care); Subject Term: PATIENTS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gwirtsman, Harry E.
AU  - Prager, Jordan
AU  - Henkin, Robert
T1  - Case Report of Anorexia Nervosa Associated with Wilson's Disease.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993/03//
VL  - 13
IS  - 2
M3  - Article
SP  - 241
EP  - 244
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Wilson's disease is a recessively inherited disorder of copper metabolism with prominent hepatic, hematopoetic, central nervous system (CNS), and ocular involvement. Psychiatric manifestations are notoriously variable. The following case history of a patient with both anorexia nervosa and Wilson's disease is presented and discussed in the context of organic CNS lesions associated with anorexia nervosa-like syndromes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL research
KW  - ANOREXIA nervosa
KW  - HEPATOLENTICULAR degeneration
KW  - CENTRAL nervous system -- Diseases
KW  - CENTRAL nervous system -- Wounds & injuries
KW  - PATHOLOGICAL psychology
KW  - PRECANCEROUS conditions
KW  - COPPER metabolism
KW  - PATIENTS
N1  - Accession Number: 11927953; Gwirtsman, Harry E. 1 Prager, Jordan 2 Henkin, Robert 3; Affiliation:  1: Chief, Mood Disorders Program, Modd, Anxiety, and Personality Disorders Research Branch, National Institute of Mental Health  2: Assistant Professor of Neuroradiology, Department of Radiology, University of Chicago, Chicago, Illinois  3: Director, The Taste and Smell Clinic, Washington, DC; Source Info: Mar1993, Vol. 13 Issue 2, p241; Subject Term: MEDICAL research; Subject Term: ANOREXIA nervosa; Subject Term: HEPATOLENTICULAR degeneration; Subject Term: CENTRAL nervous system -- Diseases; Subject Term: CENTRAL nervous system -- Wounds & injuries; Subject Term: PATHOLOGICAL psychology; Subject Term: PRECANCEROUS conditions; Subject Term: COPPER metabolism; Subject Term: PATIENTS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dawson, Deborah A.
AU  - Grant, Bridet F.
T1  - Gender effects in diagnosing alcohol abuse and dependence.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1993/03//
VL  - 49
IS  - 2
M3  - Article
SP  - 298
EP  - 307
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - Using a national population sample of 43,809 adults, male and female responses were compared for 41 indicators of alcohol abuse and dependence. While men reported all indicators more often than did women, the male to female ratio of positive responses varied according to both the construct represented by the item and its underlying prevalence. Items that might be construed as signs of weakness-physical effects, psychological effects, and loss of control or powerlessness-had lower male/female ratios than other items. Excess male prevalence was greatest for the least prevalent indicators. The paper presents alternative interpretations of these findings and discusses their implications for diagnostic classification. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOLISM -- Psychological aspects
KW  - ALCOHOLISM
KW  - SUBSTANCE abuse
KW  - DRINKING of alcoholic beverages
KW  - PSYCHOLOGY -- Research
KW  - ADDICTIONS
KW  - COMPULSIVE behavior
KW  - FAMILY SERVICES, COUNSELING, AND THERAPY
N1  - Accession Number: 9306095757; Dawson, Deborah A. 1 Grant, Bridet F. 1; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism; Source Info: Mar1993, Vol. 49 Issue 2, p298; Subject Term: ALCOHOLISM -- Psychological aspects; Subject Term: ALCOHOLISM; Subject Term: SUBSTANCE abuse; Subject Term: DRINKING of alcoholic beverages; Subject Term: PSYCHOLOGY -- Research; Subject Term: ADDICTIONS; Subject Term: COMPULSIVE behavior; Author-Supplied Keyword: FAMILY SERVICES, COUNSELING, AND THERAPY; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - RPRT
AU  - Weinberg, Wendy C.
AU  - Goodman, Linda V.
AU  - George, Carmen
AU  - Morgan, David L.
AU  - Ledbetter, Steve
AU  - Yuspa, Stuart H.
AU  - Lichti, Ulrike
T1  - Reconstitution of Hair Follicle Development <em>In Vivo</em>: Determination of Follicle Formation, Hair Growth, and Hair Quality by Dermal Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/03//
VL  - 100
IS  - 3
M3  - Report
SP  - 229
EP  - 236
SN  - 0022202X
AB  - Combinations of cultured and uncultured epidermal and dermal cell preparations from newborn and perinatal mice were grafted onto the backs of athymic nude mouse hosts to elucidate the cellular requirements for skin appendage formation. All epidermal populations studied, including a total epidermal keratinocyte preparation from trypsin-split skin, developing hair follicle buds isolated from epidermis, and pre-formed hair follicles isolated from dermis, make haired skin when grafted with fresh dermal cells. Only pre-formed hair follicles produce haired skin on grafts without an additional dermal component. Hair follicle buds grafted alone or with cultured dermal cells will reconstitute skin but without appendage formation. Thus, cells or factors present in fresh, but not cultured, dermal cells are essential for supporting hair growth from budding follicles, whereas more developed(pre-formed) follicles appear to contain all the necessary components for hair formation. Dissociation of isolated hair follicles by trypsin/ethylenediaminetetraacetic acid prior to grafting is permissive for hair growth, suggesting that follicle cells can be re-induced or reassociate <em>in vivo</em>. Dermal papilla cells, microdissected from rat vibrissal follicles and cultured for up to 14 passages, stimulate hair growth from follicle buds and influence the quality of hair growth from pre-formed hair follicles. Thus, dermal papilla cells maintain inductive capacity in culture and contribute to the reconstituted skin. This reconstitution model should be useful for identifying cell populations within the hair follicle compartment necessary for hair growth and for examining the effects of specific gene products on hair follicle growth and development <em>in vivo</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR follicles
KW  - HAIR growth stimulants
KW  - EPITHELIUM
KW  - KERATINOCYTES
KW  - HAIR cells
KW  - CELL proliferation
KW  - ETHYLENEDIAMINETETRAACETIC acid
N1  - Accession Number: 12468971; Weinberg, Wendy C. 1 Goodman, Linda V. 2 George, Carmen 3 Morgan, David L. 1 Ledbetter, Steve 2 Yuspa, Stuart H. 1 Lichti, Ulrike 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, Maryland,  U.S.A.  2: The Upjohn Company, Kalamazoo, Michigan, U.S.A.  3: National Cancer Institute, Bethesda; thocon, Inc (CG), Rockville, Maryland,  U.S.A.; Source Info: Mar1993, Vol. 100 Issue 3, p229; Subject Term: HAIR follicles; Subject Term: HAIR growth stimulants; Subject Term: EPITHELIUM; Subject Term: KERATINOCYTES; Subject Term: HAIR cells; Subject Term: CELL proliferation; Subject Term: ETHYLENEDIAMINETETRAACETIC acid; Number of Pages: 8p; Document Type: Report
L3  - 10.1111/1523-1747.ep12468971
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tucker, Margaret A.
AU  - Fraser, Mary C.
AU  - Goldstein, Alisa M.
AU  - Elder, David E.
AU  - Guerry, DuPont
AU  - Organic, Sara M.
T1  - Risk of Melanoma and Other Cancers in Melanoma-Prone Families.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/03//
VL  - 100
IS  - 3
M3  - Article
SP  - 350S
EP  - 355S
SN  - 0022202X
AB  - The article focuses on the risk of melanoma and other cancers in melanoma-prone families. Authors evaluated the risk of developing melanoma over time in members of 23 melanoma-prone families. All 23 families had dysplastic nevi as well as melanoma. Forty-seven melanomas occurred prospectively, all in family members with dysplastic melanoma. The prospective melanomas were markedly thinner than the melanomas diagnosed prior to or at the time of the subject's entry into the study. Overall, the relative risk of a prospective melanoma among family members with previous melanoma was 229.
KW  - MELANOMA
KW  - DYSPLASIA
KW  - CANCER
KW  - DISEASES -- Risk factors
KW  - BIRTHMARKS
KW  - DIAGNOSIS
KW  - FAMILY history (Sociology)
N1  - Accession Number: 12470264; Tucker, Margaret A. 1 Fraser, Mary C. 1 Goldstein, Alisa M. 1 Elder, David E. 2 Guerry, DuPont 2 Organic, Sara M. 1; Affiliation:  1: Family Studies Section, Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, Philadelphia, U.S.A.  2: Pigmented Lesion Study Group and Departments of Pathology and Medicine of the University of Pennsylvania School of Medicine, Philadelphia, U.S.A.; Source Info: Mar1993, Vol. 100 Issue 3, p350S; Subject Term: MELANOMA; Subject Term: DYSPLASIA; Subject Term: CANCER; Subject Term: DISEASES -- Risk factors; Subject Term: BIRTHMARKS; Subject Term: DIAGNOSIS; Subject Term: FAMILY history (Sociology); Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12470264
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
AU  - Piedmont, Ralph L.
T1  - Folk Concepts, Natural Language, and Psychological Constructs: The California Psychological Inventory and the Five-Factor Model.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1993/03//
VL  - 61
IS  - 1
M3  - Article
SP  - 1
EP  - 26
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Both the California Psychological Inventory (CPI; Gough, 1987) and the five-factor model of personality have roots in folk concepts of personality. The present article offers a conceptual analysis of CPI scales in terms of the five-factor model. In the first study, judges rated the item content of CPI scales in terms of the five factors. In the second, CPI scales were correlated with the factors as measured by the NEO Personality Inventory (NEO-PI; Costa & McCrae, 1985b) in a sample of 348 men and women ages 19 to 92. Both studies showed meaningful links between CPI scales and four of the factors; Agreeableness appeared to be underrepresented in CPI scales. The utility of systematic rational item analysis in terms of the five factors and the evolving relation of folk concepts to psychological constructs are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - CONSCIOUSNESS
KW  - PSYCHOLOGY
KW  - NEO Personality Inventory
N1  - Accession Number: 9303190302; McCrae, Robert R. 1 Costa Jr., Paul T. 1 Piedmont, Ralph L. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH; Source Info: Mar93, Vol. 61 Issue 1, p1; Subject Term: PERSONALITY; Subject Term: CONSCIOUSNESS; Subject Term: PSYCHOLOGY; Subject Term: NEO Personality Inventory; Number of Pages: 26p; Illustrations: 3 Charts; Document Type: Article
L3  - 10.1111/1467-6494.ep9303190302
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hilton, Michael E.
T1  - An Overview of Recent Findings on Alcoholic Beverage Warning Labels.
JO  - Journal of Public Policy & Marketing
JF  - Journal of Public Policy & Marketing
Y1  - 1993///Spring93
VL  - 12
IS  - 1
M3  - Article
SP  - 1
EP  - 9
PB  - American Marketing Association
SN  - 07439156
AB  - Summarizes the findings on the impact and the design of the warning labels on alcoholic beverages.  Behavioral changes; Interpretations of the findings; Conclusion; References.
KW  - Alcoholic beverages -- Labeling
KW  - Alcoholic beverages
N1  - Accession Number: 9602160579; Hilton, Michael E. 1; Affiliations: 1: Health Scientist Administrator, Division of Clinical and Prevention Research, National Institute on Alcohol Abuse and Alcoholism.; Issue Info: Spring93, Vol. 12 Issue 1, p1; Subject Term: Alcoholic beverages -- Labeling; Subject Term: Alcoholic beverages; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 312140 Distilleries; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 8051
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
AU  - Waclawiw, Myron A.
AU  - Kung-Yee Liang
T1  - Prediction of Random Effects in the Generalized Linear Model.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1993/03//
VL  - 88
IS  - 421
M3  - Article
SP  - 171
EP  - 178
SN  - 01621459
AB  - This article develops an estimating function-based approach to component estimation in the two-stage generalized linear model with univariate random effects and a vector of fixed effects. The novelty and unifying feature of the method is the use of estimating functions in the estimation of both the random effects and their variance. Two separate estimating procedures based on the method are proposed that differ in the intensity of numerical computation required. The estimating function approach is especially valuable in the longitudinal setting where the response variable is discrete and the number of repeated observations on each unit is small. Other key features of this empirical Bayes technique are that it uses all available data, it yields familiar forms for the estimators as special cases, and it is less computationally intensive than other methods designed to address the same problem. An application to the estimation of trends in acquired immune deficiency syndrome (AIDS) incidence across risk groups and geographical regions is presented. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESTIMATION theory
KW  - LINEAR models (Statistics)
KW  - MATHEMATICAL models
KW  - MATHEMATICAL statistics
KW  - BAYESIAN analysis
KW  - STATISTICAL decision making
KW  - Empirical Bayes estimation
KW  - Estimating function
KW  - Generalized linear model
KW  - Longitudinal studies
KW  - Two-stage random effects model
N1  - Accession Number: 9512310145; Waclawiw, Myron A. 1; Kung-Yee Liang 2; Affiliations: 1: Mathematical Statistician, Biostatistics Research Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-0001.; 2: Professor, Department of Biostatistics, Johns Hopkins University, Baltimore. MD 21205.; Issue Info: Mar1993, Vol. 88 Issue 421, p171; Thesaurus Term: ESTIMATION theory; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: MATHEMATICAL models; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: BAYESIAN analysis; Thesaurus Term: STATISTICAL decision making; Author-Supplied Keyword: Empirical Bayes estimation; Author-Supplied Keyword: Estimating function; Author-Supplied Keyword: Generalized linear model; Author-Supplied Keyword: Longitudinal studies; Author-Supplied Keyword: Two-stage random effects model; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article; Full Text Word Count: 6695
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Carroll, R. J.
AU  - Gail, M. H.
AU  - Lubin, J. H.
T1  - Case-Control Studies With Errors in Covariates.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1993/03//
VL  - 88
IS  - 421
M3  - Article
SP  - 185
EP  - 199
SN  - 01621459
AB  - We devise methods for estimating the parameters of a prospective logistic model with dichotomous response D and arbitrary covariates X from case-control data when these covariates are measured with error. We suppose that some fraction of the cases and controls provide only the error-prone covariate measurements, W (the "incomplete" or "reduced" data), whereas some of the cases and controls provide measurements on X and W (the "complete" data). We assume a measurement error density with a finite set of parameters α, namely fW/XD(W∣x, d,α), and nondifferential error is treated as a special case of this model, fW/X(W∣x, d,α). Our algorithm estimates both the logistic parameters and α from a pseudolikelihood. Because empirical distribution functions are used in place of needed distributions in the pseudolikelihoods, the required asymptotic theory is more elaborate than for pseudolikelihoods based on substitution for a finite number of nuisance parameters. We also examine computationally simpler methods under the assumptions that the disease is rare and that errors are nondifferential. Estimates of m(W ) = E(X\W ) are substituted for X in the logistic model when X is not available. Such estimates of m(W) can he obtained from the complete data described above or from an independent validation study. If measurements on X are not available, m(W) can still be estimated from replicated W measurements in some circumstances. A final approach uses approximate logistic regression techniques and is appropriate when a more accurate approximation is required than obtained by simply substituting m(W) for X. Asymptotic theory is presented for each of these procedures, and examples are used to illustrate the calculations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISTRIBUTION (Probability theory)
KW  - ESTIMATES
KW  - REGRESSION analysis
KW  - ALGORITHMS
KW  - ANALYSIS of covariance
KW  - PROBABILITY theory
KW  - Asymptotics: Case-control study
KW  - Differential misclassification
KW  - Errors in variables
KW  - Logistic regression: Pseudolikelihood
N1  - Accession Number: 9512310147; Carroll, R. J. 1; Gail, M. H. 2; Lubin, J. H. 3; Affiliations: 1: Professor of Statistics and Toxicology, Department of Statistics, Texas A & M University, College Station, TX 77843-3143.; 2: Epidemiologic Methods Section, National Cancer Institute, Bethesda, MD 20892.; 3: Senior Health Statistician, National Cancer Institute, Bethesda, MD 20892.; Issue Info: Mar1993, Vol. 88 Issue 421, p185; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ESTIMATES; Thesaurus Term: REGRESSION analysis; Thesaurus Term: ALGORITHMS; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: PROBABILITY theory; Author-Supplied Keyword: Asymptotics: Case-control study; Author-Supplied Keyword: Differential misclassification; Author-Supplied Keyword: Errors in variables; Author-Supplied Keyword: Logistic regression: Pseudolikelihood; Number of Pages: 15p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 12603
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Albert, Paul S.
T1  - Statistical Models for Longitudinal Studies of Health.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1993/03//
VL  - 88
IS  - 421
M3  - Book Review
SP  - 378
EP  - 379
SN  - 01621459
AB  - Reviews the book "Statistical Models for Longitudinal Studies of Health," edited by James H. Dweyer, Manning Feinleib, Peter Lippert and Hans Hoffmeister.
KW  - LONGITUDINAL method
KW  - NONFICTION
KW  - DWEYER, James H.
KW  - FEINLEIB, Manning
KW  - LIPPERT, Peter
KW  - HOFFMEISTER, Hans
KW  - STATISTICAL Models for Longitudinal Studies of Health (Book)
N1  - Accession Number: 9512310173; Albert, Paul S. 1; Affiliations: 1: National Institute of Neurological Disorders and Stroke.; Issue Info: Mar1993, Vol. 88 Issue 421, p378; Subject Term: LONGITUDINAL method; Subject Term: NONFICTION; Reviews & Products: STATISTICAL Models for Longitudinal Studies of Health (Book); People: DWEYER, James H.; People: FEINLEIB, Manning; People: LIPPERT, Peter; People: HOFFMEISTER, Hans; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 1160
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Pillar, Barbara
T1  - Orphan Products: Drugs and Devices for Rare Diseases.
JO  - Nursing Economic$
JF  - Nursing Economic$
Y1  - 1993/03//Mar/Apr93
VL  - 11
IS  - 2
M3  - Article
SP  - 99
EP  - 101
PB  - Jannetti Publications, Inc.
SN  - 07461739
AB  - Health care technology is often criticized for contributing to high costs without assuring increased quality or equitable availability. Moreover, there is a group of drugs and devices that have a narrow range of efficacy, little demand, and require considerable expenditure in public funds to ensure their development. These are the orphan products, which are drugs and devices needed by people with rare diseases, that affect so few persons that pharmaceutical manufacturers do not find it profitable to develop and market the products. The article analyses the efforts made by different health care agencies in ensuring the effectiveness and adequate supply of these orphan products.
KW  - ORPHAN drugs
KW  - RARE diseases
KW  - MEDICAL technology
KW  - QUALITY assurance
KW  - MEDICAL equipment
KW  - MEDICAL care costs
N1  - Accession Number: 12242019; Pillar, Barbara 1; Affiliation:  1: Staff of the National Center for Nursing Research, National Institutes of Health, Bethesda MD.; Source Info: Mar/Apr93, Vol. 11 Issue 2, p99; Subject Term: ORPHAN drugs; Subject Term: RARE diseases; Subject Term: MEDICAL technology; Subject Term: QUALITY assurance; Subject Term: MEDICAL equipment; Subject Term: MEDICAL care costs; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Anderson, David E.
AU  - Austin, Joy
AU  - Haythornthwaite, Jennifer A.
T1  - Blood pressure during sustained inhibitory breathing in the natural environment.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1993/03//
VL  - 30
IS  - 2
M3  - Article
SP  - 131
EP  - 137
SN  - 00485772
AB  - Previous studies reported that breathing frequency of laboratory dogs decreased preceding the onset of an avoidance task and that this decrease was accompanied by increases in blood pressure and decreases in heart rate. Low frequency/normal tidal volume breathing has also been observed in ambulatory humans, but the cardiovascular concomitants of this inhibitory breathing pattern remain to be determined. The present study recorded blood pressure and heart rate in humans during periods of inhibitory breathing in the natural environment. Systolic and mean pressure were higher during inhibitory breathing than at other times, but no differences in diastolic pressure or heart rate were observed. Inhibitory breathing was differentially associated with the workplace and with social situations. Thus, major components of a physiological pattern that predisposes laboratory animals to sodium-sensitive experimental hypertension have now been observed to covary in ambulatory humans. Whether inhibitory breathing in the natural environment is a correlate or a cause of elevated blood pressure remains to be determined. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BLOOD pressure
KW  - HEART beat
KW  - RESPIRATION
KW  - HEMODYNAMICS
KW  - BODY fluids -- Pressure
KW  - CARDIOVASCULAR system
KW  - Blood pressure
KW  - Cardiovascular ambulatory monitoring.
KW  - Heart rate
KW  - Respiration
N1  - Accession Number: 11037314; Anderson, David E. 1 Austin, Joy 1 Haythornthwaite, Jennifer A. 1; Affiliation:  1: Laboratory of Behavioral Sciences, National Institute on Aging, Baltimore, MD; Source Info: Mar1993, Vol. 30 Issue 2, p131; Subject Term: BLOOD pressure; Subject Term: HEART beat; Subject Term: RESPIRATION; Subject Term: HEMODYNAMICS; Subject Term: BODY fluids -- Pressure; Subject Term: CARDIOVASCULAR system; Author-Supplied Keyword: Blood pressure; Author-Supplied Keyword: Cardiovascular ambulatory monitoring.; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Respiration; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1469-8986.ep11037314
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hawkins, Andre M.
AU  - Burgio, Louis D.
AU  - Langford, Anita
AU  - Engel, Bernard T.
T1  - The Effects of Verbal and Written Supervisory Feedback on Staff Compliance with Assigned Prompted Voiding in a Nursing Home.
JO  - Journal of Organizational Behavior Management
JF  - Journal of Organizational Behavior Management
Y1  - 1993/03/04/
VL  - 13
IS  - 1
M3  - Article
SP  - 137
EP  - 150
SN  - 01608061
AB  - We examined the effects of staff performance feedback delivered by a supervisor verbally, and combined with written feedback on geriatric nursing assistants' (GNAs) completion of assigned prompted voiding. The goal of the staff management procedures was to increase the frequency of prompted voiding which would consequently maintain improvements in continence brought about on a specialized continence unit. The basic staff management system included GNA self-monitoring of their performance of prompted voiding, periodic supervisory monitoring, and verbal and graphic feedback provided to all GNAs on their performance. At a later time, the staff management program was modified to include letters of praise or disapproval sent bi-weekly to all GNAs based on their performance of the prompted voiding procedure. Also, a letter was sent to all GNAs every three months summarizing their performance during this period. These summary letters were placed in the GNAs' personnel file and used as part of their annual performance evaluation. Results suggest that, although individual verbal feedback alone resulted in acceptable maintenance of prompted voiding, the addition of written feedback produced significant improvements in the number of assigned prompted voiding completed. This study displays the utility and practicality of employing formalized staff management procedures in nursing homes. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Journal of Organizational Behavior Management is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75439113; Hawkins, Andre M. 1 Burgio, Louis D. 2 Langford, Anita 3 Engel, Bernard T. 4; Affiliation:  1: Department of Psychology, University of Cincinnati  2: Division of Geriatric Medicine, University of Alabama, Birmingham, AL, 35294-4410  3: Francis Scott Key Medical Center, Baltimore, MD  4: Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Gerontology Research Center, Baltimore, MD; Source Info: Mar1993, Vol. 13 Issue 1, p137; Number of Pages: 14p; Document Type: Article
L3  - 10.1300/J075v13n01_09
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sinha, Rashmi
AU  - Block, Gladys
AU  - Taylor, Philip R.
T1  - Problems with estimating vitamin C intakes.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/04//
VL  - 57
IS  - 4
M3  - Article
SP  - 547
EP  - 550
SN  - 00029165
AB  - The vitamin C content of foods was examined from two national databases and new values were obtained by HPLC. HPLC values were lower in four of the five highest vitamin C contributors to the US diet (orange juice, grapefruit, tomatoes and tomato juice, and potatoes), as well as in broccoli, red peppers, and cooked collard and mustard greens, compared with values from the other databases. When HPLC values were substituted in the Health Habits and History Questionnaire, the resulting estimates of dietary intake of vitamin C in two studies were lower. Despite these lower estimates of absolute intake, in one study the correlation between dietary vitamin C and plasma ascorbic acid was similar. In conclusion, the accuracy of the vitamin C content of foods is important for estimating the absolute amount of vitamin C intake in the population but may not change the ranking of people in epidemiological studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epidemiology
KW  - Food -- Vitamin C content
KW  - Fruit -- Vitamin C content
KW  - High performance liquid chromatography
KW  - Questionnaires
KW  - dehydroascorbic acid
KW  - high-performance liquid chromatography
KW  - National Health and Nutrition Examination Survey
KW  - National Health Interview Survey
KW  - Vitamin C. ascorbic acid
N1  - Accession Number: 94403119; Sinha, Rashmi 1,2; Block, Gladys 1,2; Taylor, Philip R. 1,2; Affiliations: 1: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; 2: Department of Public Health Nutrition, University of California, Berkeley; Issue Info: Apr1993, Vol. 57 Issue 4, p547; Thesaurus Term: Epidemiology; Subject Term: Food -- Vitamin C content; Subject Term: Fruit -- Vitamin C content; Subject Term: High performance liquid chromatography; Subject Term: Questionnaires; Author-Supplied Keyword: dehydroascorbic acid; Author-Supplied Keyword: high-performance liquid chromatography; Author-Supplied Keyword: National Health and Nutrition Examination Survey; Author-Supplied Keyword: National Health Interview Survey; Author-Supplied Keyword: Vitamin C. ascorbic acid; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rautalahti, Matti
AU  - Albanes, Demetrius
AU  - Haukka, Jari
AU  - Roos, Eva
AU  - Gref, Carl-Gustaf
AU  - Virtamo, Jarmo
T1  - Seasonal variation of serum concentrations of β-carotene and α-tocopherol.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/04//
VL  - 57
IS  - 4
M3  - Article
SP  - 551
EP  - 556
SN  - 00029165
AB  - We studied the seasonal variation in serum concentrations of β-carotene and α-tocopherol (HPLC) in 17 247 Finnish men who smoked. Month of blood sampling was a statistically significant determinant of serum concentration of β-carotene in a regression model including age, body mass index, alcohol and fat intakes, total serum cholesterol, and daily cigarettes as covariates. The serum concentrations were lowest in April-June and highest in October-November. The 1.5-fold increase in the serum concentration of β-carotene during the fall reflects the seasonality of dietary sources of carotenoids in Finland. The serum concentrations of α-tocopherol demonstrated no seasonal variation but remained close to 27.6 µmol/ L throughout the year. The results indicate that the seasonal variation of serum concentrations of β-carotene should be taken into account in long-term studies in which comparison of groups or individuals is based on serum concentrations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Vitamin E deficiency
KW  - Physiology -- Seasonal variations
KW  - Body mass index
KW  - Carotene in the blood
KW  - Blood proteins
KW  - Regression analysis
KW  - α-tocopherol
KW  - β-carotene
KW  - Seasonal variation
KW  - serum vitamins
N1  - Accession Number: 94403116; Rautalahti, Matti 1,2; Albanes, Demetrius 1,2; Haukka, Jari 1,2; Roos, Eva 1,2; Gref, Carl-Gustaf 1,2; Virtamo, Jarmo 1,2; Affiliations: 1: National Public Health Institute, Helsinki; 2: National Cancer Institute, Bethesda, MD; Issue Info: Apr1993, Vol. 57 Issue 4, p551; Subject Term: Vitamin E deficiency; Subject Term: Physiology -- Seasonal variations; Subject Term: Body mass index; Subject Term: Carotene in the blood; Subject Term: Blood proteins; Subject Term: Regression analysis; Author-Supplied Keyword: α-tocopherol; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: Seasonal variation; Author-Supplied Keyword: serum vitamins; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Krasnegor, Norman A.
T1  - Improving the Long-term Management of Obesity: Theory, Research, and Clinical Guidelines.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/04//
VL  - 57
IS  - 4
M3  - Book Review
SP  - 601
EP  - 602
SN  - 00029165
KW  - Perri, Michael G.
KW  - Nezu, Arthur M.
KW  - Viegener, Barbara J.
KW  - Improving the Long-Term Management of Obesity: Theory, Research & Clinical Guidelines (Book)
N1  - Accession Number: 94403111; Krasnegor, Norman A. 1; Affiliations: 1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Issue Info: Apr1993, Vol. 57 Issue 4, p601; Reviews & Products: Improving the Long-Term Management of Obesity: Theory, Research & Clinical Guidelines (Book); People: Perri, Michael G.; People: Nezu, Arthur M.; People: Viegener, Barbara J.; Number of Pages: 2p; Document Type: Book Review
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ER  - 
TY  - JOUR
AU  - Ahmed, F.
AU  - Clemens, J. D.
AU  - Rao, M. R.
AU  - Khan, M. R.
AU  - Haque, E.
T1  - Initiation of food supplements and stopping of breast-feeding as determinants of weanling shigellosis.
T2  - Le début de l'alimentation et l'arrêt de l'allaitement au sein en tant que déterminants de la shigellose en période de sevrage.
JO  - Bulletin of the World Health Organization
JF  - Bulletin of the World Health Organization
Y1  - 1993/04//
VL  - 71
IS  - 5
M3  - Article
SP  - 571
EP  - 578
PB  - World Health Organization
SN  - 00429686
AB  - The association between the period elapsed since weaning and the risk of shigellosis was assessed between 1 November 1987 and 30 November 1989 for a cohort of 1085 Bangladeshi children aged <3 years. The children were followed for 1 month after exposure to Shigella spp. in their residential neighbourhoods, and the 268 who developed microbiologically confirmed (n = 118) or clinically presumptive (n = 150) shigellosis were compared with the 817 control children who did not develop either syndrome. No increase in risk was noted among breast-fed infants who received food supplements within the previous 3 months compared with those who had received supplements for longer (adjusted odds ratio (OR) = 1.2; 95% confidence interval (CI) = 0.4-3.0). However, compared with breast-fed children, non-breast-fed children had an increased risk (adjusted OR = 2.0; 95% CI = 1.3-2.9; P <0.001), which was largely attributable to a substantially increased risk in the 3 months after stopping breast-feeding (adjusted OR = 6.6; 95% CI = 2.9-14.6; P <0.001). The early post-cessation risk was equivalent for confirmed and presumptive shigellosis, but was particularly pronounced among the severely malnourished (adjusted OR = 10.2; 95% CI = 3. 1-33.3; P <0.001). This complex temporal pattern of risk highlights the need for precise definitions of weaning to facilitate identification of children at high risk for invasive diarrhoeal syndromes. (English) [ABSTRACT FROM AUTHOR]
AB  - Malgré un risque accru de diarrhée infantile lors du passage de l'allaitement au sein exclusif à une alimentation adulte, rares sont les études étiologiques portant sur ce sujet. La présente étude examine l'association entre le processus de sevrage et la shigellose chez une cohorte de 1085 enfants d'une région rurale du Bangladesh âgés de moins de trois ans. L'étude a été conduite entre le 1er novembre 1987 et le 30 novembre 1989 sur des enfants exposés à Shigella dans leur quartier de résidence; chaque enfant a été suivi pendant un mois au moyen de visites à domicile. L'association a été attestée par une relation entre les antécédents alimentaires et la survenue d'une shigellose confirmée ou présumée. Les auteurs ont comparé les 268 cas de shigellose confirmée par examen microbiologique (n = 118) ou présumée d'après les données cliniques (n = 150), avec les 817 enfants témoins n'ayant présenté aucun de ces syndromes. Aucune augmentation du risque n'a été notée chez les enfants nourris au sein et ayant commencé à recevoir un complément d'alimentation au cours des trois mois précédents, par rapport à ceux ayant commencé à recevoir une alimentation variée depuis plus longtemps (odds ratio (OR) corrigé = 1,2; intervalle de confiance (IC) à 95% = 0,4-3,0). En revanche, une augmentation du risque a été observée chez les enfants qui n'étaient plus allaités au sein par rapport à ceux qui l'étaient encore (OR corrigé = 2,0; IC 95% = 1,3-2,9; P <0,001), et a été considérée comme fortement imputable à une augmentation sensible du risque au cours des trois premiers mois suivant l'arrêt de l'allaitement au sein (OR corrigé = 6,6; IC 95% = 2,9-14,6; P <0,001). Le risque au début du sevrage était équivalent pour la shigellose confirmée et présumée, mais était particulièrement prononcé chez les enfants atteints de malnutrition sévère et présentant un retard de croissance important (OR corrigé = 10,2; IC 95% = 3,1-33,3; P <0,001). Les résultats de cette étude indiquent que le risque de shigellose ne varie pas notablement selon la période écoulée depuis le début de l'introduction d'une alimentation variée, mais augmente sensiblement, bien que temporairement, lors de l'arrêt de l'allaitement au sein. Cette évolution complexe du risque au cours des différentes étapes du sevrage souligne la nécessité d'une définition précise du sevrage dans les études épidémiologiques. D'un point de vue pratique, du fait de la brièveté de la période de risque élevé de shigellose après l'arrêt de l'alimentation au sein, et de l'âge très inégal auquel les enfants d'une population donnée cessent d'être allaités, il est difficile de mettre en œuvre des programmes de vaccination efficaces contre la shigellose, en particulier avec les vaccins buccaux vivants. Pour être protecteurs, ces vaccins devront être administrés tôt dans la vie, avant l'arrêt de l'alimentation au sein; mais leur immunogénicité peut être fortement atténuée par l'ingestion de lait maternel.… (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Dietary supplements
KW  - Breastfeeding (Humans)
KW  - Shigellosis
KW  - Children
KW  - Diarrhea
KW  - Bangladesh
N1  - Accession Number: 24756035; Ahmed, F. 1,2; Clemens, J. D. 3,4; Rao, M. R. 5,6; Khan, M. R. 7; Haque, E. 8; Affiliations: 1: Principal Investigator, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Dhaka, Bangladesh; 2: Visiting Fellow, Division of Epidemiology, Statistics, and Prevention Research (DESPR), National Institute of Child Health and Human Development (NICHD), 6100 Executive Plaza Building, Bethesda, MD 20892, USA; 3: Scientist, ICDDR, B, Dhaka, Bangladesh; 4: Chief, Epidemiology Branch, DESPR, NICHD, Bethesda, MD, USA; 5: Consultant, ICDDR, B, Dhaka, Bangladesh; 6: Visiting Associate, DESPR, NICHD, Bethesda, MD, USA; 7: Manager, ICDDR, B, Dhaka, Bangladesh; 8: Senior Field Research Officer, ICDDR, B, Dhaka, Bangladesh; Issue Info: 1993, Vol. 71 Issue 5, p571; Thesaurus Term: Dietary supplements; Subject Term: Breastfeeding (Humans); Subject Term: Shigellosis; Subject Term: Children; Subject Term: Diarrhea; Subject: Bangladesh; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Thompson, H. L.
AU  - Thomas, L.
AU  - Metcalfe, D. D.
T1  - Murine mast cells attach to and migrate on laminin-, fibronectin-, and matrigel-coated surfaces in response to FcεRI-mediated signals.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1993/04//
VL  - 23
IS  - 4
M3  - Article
SP  - 270
EP  - 275
PB  - Wiley-Blackwell
SN  - 09547894
AB  - We have examined the possibility that mouse bone marrow-derived cultured mast cells (BMCMC) have the capacity to attach to and migrate on extracellular matrix components in vitro through the use of time lapse videography. Unactivated mast cells did not display significant interaction with slide flasks coated with either 3% BSA or collagen IV, and FcεRI-mediated activation of BMCMC did not appreciably increase their attachment and migratory characteristics. Both activated and unactivated BMCMC adhered to surfaces coated with a synthetic IKVAV laminin polypeptide, but this association resulted in the immobilization of the cells to the substrate. BMCMC did not adhere to surfaces coated with laminin, fibronectin or matrigel until FcεRI-mediated activation, after which they displayed rapid, random movement on these surfaces. Cells continually interacted with laminin, fibronectin or matrigel by flattening, interspaced by periods of movement as rounded cells with small pseudopodia. The mean velocity of BMCMC on laminin, fibronectin or matrigel was similar and averaged approximately 180 μm/hr. The mean velocity of BMCMC on these three substrates was not significantly different from the mean velocity of monocytes on laminin. The movement of BMCMC on these substrates demonstrated a directional tendency. In summary, these results demonstrate that mast cells activated through FcεRI are capable of attachment to and motion on components of extracellular matrix, and demonstrate one mechanism by which mast cells may migrate to areas of inflammation and wound repair. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cells
KW  - BONE marrow
KW  - EXTRACELLULAR matrix
KW  - MICE as laboratory animals
KW  - FIBRONECTINS
KW  - MONOCYTES
N1  - Accession Number: 16320047; Thompson, H. L. 1 Thomas, L. 2 Metcalfe, D. D. 1; Affiliation:  1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases  2: Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr1993, Vol. 23 Issue 4, p270; Subject Term: MAST cells; Subject Term: BONE marrow; Subject Term: EXTRACELLULAR matrix; Subject Term: MICE as laboratory animals; Subject Term: FIBRONECTINS; Subject Term: MONOCYTES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Eveleth, Phyllis B.
T1  - Biology of Aging: Observations and Principles.
JO  - Human Biology
JF  - Human Biology
Y1  - 1993/04//
VL  - 65
IS  - 2
M3  - Book Review
SP  - 332
EP  - 333
SN  - 00187143
AB  - The article reviews the book "Biology of Aging: Observations and Principles," by Robert Arking.
KW  - AGING
KW  - NONFICTION
KW  - ARKING, Robert
KW  - BIOLOGY of Aging: Observations & Principles (Book)
N1  - Accession Number: 24688596; Eveleth, Phyllis B. 1; Affiliation:  1: National Institute on Aging, National Institutes of Health, Bethesda, MD 20892; Source Info: Apr93, Vol. 65 Issue 2, p332; Subject Term: AGING; Subject Term: NONFICTION; Reviews & Products: BIOLOGY of Aging: Observations & Principles (Book); People: ARKING, Robert; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hashimoto, Takashi
AU  - Ebihara, Tamotsu
AU  - Ishiko, Akira
AU  - Shimizu, Hiroshi
AU  - Bhogal, Balbir S.
AU  - Black, Martin M.
AU  - Stanley, John R.
AU  - Nishikawa, Takeji
T1  - Comparative Study of Bullous Pemphigoid Antigens Among Japanese, British, and U.S. Patients Indicates Similar Antigen Profiles with the 170-kD Antigen Present both in the Basement Membrane and on the Keratinocyte Cell Membrane.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/04//
VL  - 100
IS  - 4
M3  - Article
SP  - 385
EP  - 389
SN  - 0022202X
AB  - There are a number of controversies relating to studies of bullous pemphigold (BP) antigens from different institutions, mainly regarding the detection of the 230-kD and 170-kD BP antigens. In this study, in an attempt to resolve the discrepancies, we have examined and compared the reactivity by immunofluorescence, immunoblotting, and immunoprecipitation among the sera from Japanese, British and U.S. BP patients. Both the 230-kD and 170-kD BP antigens were detected by various sera from all population with immunoblotting, whereas immunoprecipitation detected only the 230-kD BP antigen but not the 170-kD BP antigen. Immunoprecipitation was more sensitive than immunoblotting to detect the 230-kD antigen. These results indicate that both the 230-kD and 170-kD proteins are BP antigens found in all three populations. By immunofluorescence cell surface staining in the lower epidermis in addition to basement membrane zone staining was shown by a considerable number of patients' sera in all populations. Comparison between the result of immunofluorescence and immunoblotting revealed a clear correlation of this cell surface staining with the presence of antibodies against the 170-kD BP antigen. That the affinity-purified antibodies specific to the 170-kD BP antigen showed this cell surface staining further confirmed this correlation. These results may indicating a different nature of the 170-kD BP antigen from that of the 230-kD BP antigen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - BASAL lamina
KW  - IMMUNOFLUORESCENCE
KW  - IMMUNOBLOTTING
KW  - EPIDERMIS
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 12471985; Hashimoto, Takashi 1 Ebihara, Tamotsu 1 Ishiko, Akira 1 Shimizu, Hiroshi 1 Bhogal, Balbir S. 2 Black, Martin M. 2 Stanley, John R. 3 Nishikawa, Takeji 1; Affiliation:  1: Department of Dermatology, Kern University School of Medicine, Tokyo, Japan  2: Dowling Skin Unit, St. Thomas' Hospital, London, U.K  3: Dermatology Branch, National Cancer Institute, National Institutes for Health, Bethesda, Maryland, U.S.A.; Source Info: Apr93, Vol. 100 Issue 4, p385; Subject Term: ANTIGENS; Subject Term: BASAL lamina; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNOBLOTTING; Subject Term: EPIDERMIS; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12471985
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1993-40468-001
AN  - 1993-40468-001
AU  - Kapoula, Z.
AU  - Robinson, D. A.
AU  - Optican, L. M.
T1  - Visually induced cross-axis postsaccadic eye drift.
JF  - Journal of Neurophysiology
JO  - Journal of Neurophysiology
JA  - J Neurophysiol
Y1  - 1993/04//
VL  - 69
IS  - 4
SP  - 1031
EP  - 1043
CY  - US
PB  - American Physiological Society
SN  - 0022-3077
SN  - 1522-1598
N1  - Accession Number: 1993-40468-001. PMID: 8492146 Partial author list: First Author & Affiliation: Kapoula, Z.; NIH, National Eye Institute Lab of Sensorimotor Research, Bethesda, MD, US. Release Date: 19931101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Eye Movements. Minor Descriptor: Sensory Adaptation. Classification: Physiological Processes (2540). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: Apr, 1993. 
AB  - Examined cross-axis postsaccadic drift plasticity in 5 adults adapted to horizontal, optically induced retinal slip, coupled with vertical saccades. Ss were asked to continuously explore, with saccades, a random-dot pattern. Within 3 hrs, all Ss developed horizontal ocular drift that would reduce retinal slip. The horizontal drift occurred in the absence of a horizontal saccade, in many instances in the absence of any sort of horizontal eye displacement. The cross-axis drift had an exponential waveform and persisted in the dark and even in the presence of stationary light-emitting diodes. The onset of the drift showed no consistent lead or lag relative to the end of the vertical saccade, indicating a latency of 0. In the context of a learning neural network, this result is consistent with the notion that the network will learn only what is asked. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adaptation to horizontal retinal slip with vertical saccades
KW  - cross axis postsaccadic eye drift plasticity
KW  - 18–32 yr olds
KW  - 1993
KW  - Eye Movements
KW  - Sensory Adaptation
KW  - 1993
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105849769
T1  - Biological basis for cancer treatment.
AU  - Chabner BA
Y1  - 1993/04/15/
N1  - Accession Number: 105849769. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Chabner BA. Biological basis for cancer treatment. ANN INTERN MED 1993 Apr 15; 118(8): 633-7. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Antineoplastic Agents -- Therapeutic Use
KW  - Neoplasms -- Therapy
KW  - Apoptosis -- Drug Effects
KW  - Cell Physiology -- Drug Effects
KW  - Drug Resistance
KW  - Gene Therapy
KW  - Immunotherapy
KW  - Neoplasms -- Drug Therapy
KW  - Neoplasms -- Physiopathology
SP  - 633
EP  - 637
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 118
IS  - 8
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
AB  - The new knowledge of the regulation of cell growth and the genetic and biochemical changes that lead to malignancy have created many new opportunities for cancer drug discovery. These new targets include oncogenes, growth factors and their receptors, signal transduction pathways, and cell differentiation signals. Attempts to identify new therapies based on these targets can complement traditional drug discovery efforts that rely on high-volume screening of candidate natural products and synthetic chemicals against human tumor cell lines and against defined molecular reactions. Through modern computer-based data analysis, drug screening data can be used to establish mechanism of drug action of new agents; these analyses shed light on patterns of cross-resistance of new compounds and their interactions with defined molecular targets as well as allow selection of chemically and biologically unique agents as candidates for clinical development.
SN  - 0003-4819
AD  - Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, MD 20892.
U2  - PMID: 8452330.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Vázquez, Martha
AU  - Santana, Olivia
AU  - Quinto, Carmen
T1  - The Nodi and NodJ proteins from Rhizobium and Bradyrhizobium strains are similar to capsular polysaccharide secretion proteins from Gram-negative bacteria.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/04/15/
VL  - 8
IS  - 2
M3  - Article
SP  - 369
EP  - 377
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The Nodl and NodJ nodulation proteins have been described in different <em>Rhizobium</em> and <em>Bradyrhizobium</em> species. The <em>nodlJ</em> genes belong to the <em>nod</em> regulon. Other genes from this regulon are involved in the biosynthesis and modification of lipo-oligosaccharide molecule(s) which are morphogenic signals when acting on legume roots. It has been proposed that the Nodl and NodJ proteins belong to a bacterial inner membrane transport system of small molecules. Nucleotide sequencing of Mudll PR13 insertions in the nodulation region of the symbiotic plasmid from a <em>Rhizobium leguminosarum</em> bv. <em>phaseoli</em> strain CE3 has revealed the presence of <em>nodl</em> and <em>nodJ</em>-related sequences downstream of <em>nodC</em>. Computer nucleotide sequence analysis of the entire Nodl and NodJ sequences from <em>R. leguminosarum</em> by. <em>viciae</em> and <em>Bradyrhizobium japonicum</em> strains show that both proteins are similar to the KpsT and KpsM proteins from <em>Escherichia coli</em> K1 and K5 strains, to the BexB and BexA proteins from <em>Haemophilis influenzae</em> and to the CtrD and CtrC proteins from <em>Neisseria meningitides</em>, respectively. Except for the Nodl and NodJ proteins, all of them have been involved in the mechanism of secretion of polysaccharides in each of their harbouring species. On the basis of the similarity found, we propose that the Nodl and the NodJ proteins could be involved in the export of a lipo-oligosaccharide. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Polysaccharides
KW  - Legumes
KW  - Proteins
KW  - Rhizobium
KW  - Genes
KW  - Oligosaccharides
N1  - Accession Number: 16436017; Vázquez, Martha 1,2; Santana, Olivia 1; Quinto, Carmen 1; Affiliations: 1: Instituto de Biotecnología, Universidad Nacional Automa de México, Apartado Postal 510-3, Cuernavaca Morelos 62271, México; 2: Building 6B, Room 3B-331, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Apr1993, Vol. 8 Issue 2, p369; Thesaurus Term: Escherichia coli; Thesaurus Term: Polysaccharides; Thesaurus Term: Legumes; Subject Term: Proteins; Subject Term: Rhizobium; Subject Term: Genes; Subject Term: Oligosaccharides; Number of Pages: 9p; Illustrations: 3 Diagrams, 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104788829
T1  - Paternal lineage of alcoholism, cohort effects, and alcoholism criteria.
AU  - De Jong, J A
AU  - Roy, A
Y1  - 1993/05//
N1  - Accession Number: 104788829. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcoholism
KW  - Children of Impaired Parents -- Psychosocial Factors
KW  - Social Environment
KW  - Adult
KW  - Alcohol Drinking
KW  - Alcoholism -- Classification
KW  - Alcoholism -- Psychosocial Factors
KW  - Prospective Studies
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Models, Biological
KW  - Risk Factors
SP  - 623
EP  - 629
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 5
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Adoption studies have led to the suggestion that there may be two distinct subgroups of alcoholics with differing genetic contributions. Among 249 male alcoholics we used discriminant analysis to relate the features of type 1 and type 2 alcoholism to the presence or absence of a family history of alcoholism in male paternal relatives. We found that guilt and binging, features usually attributed to type 1 (milieu-limited) alcoholism, were in fact more prevalent in the family history positive group. An additional cohort analysis found cohort-related variations in type 1/type 2 characteristics. The possible implications of these findings are discussed.
SN  - 0965-2140
AD  - Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
U2  - PMID: 8518712.
DO  - 10.1111/j.1360-0443.1993.tb02074.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Levin, Ephraim Y.
AU  - Bier, Dennis M.
T1  - Research directions in nutrition: view from the NICHD.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/05//
VL  - 57
IS  - 5
M3  - Article
SP  - 603
EP  - 604
SN  - 00029165
AB  - The article focuses on the nutritional research and the role of the U.S. National Institute of Child Health and Human Development (NICHD) on the same. Nutrition research discussed include studying the consequences of food or nutrient intake, classifying genes which encodes nucleic acid-binding and gene-regulating proteins containing zinc-finger domains and studying the assessment of nutritional status during psychological aspects and physiological aspects of food intake through NICHD's funding.
KW  - Nutrition research
KW  - Food consumption -- Psychological aspects
KW  - Ingestion -- Physiological aspects
KW  - Zinc-finger proteins
KW  - Nutritional status
KW  - National Institute of Child Health & Human Development (U.S.)
N1  - Accession Number: 94403136; Levin, Ephraim Y. 1,2; Bier, Dennis M. 1,2; Affiliations: 1: Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Bethesda, MD; 2: Metabolism Division, School of Medicine, Washington University, St Louis; Issue Info: May1993, Vol. 57 Issue 5, p603; Subject Term: Nutrition research; Subject Term: Food consumption -- Psychological aspects; Subject Term: Ingestion -- Physiological aspects; Subject Term: Zinc-finger proteins; Subject Term: Nutritional status ; Company/Entity: National Institute of Child Health & Human Development (U.S.); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ovaskainen, Marja-Leena
AU  - Virtamo, Jarmo
AU  - Alfthan, Georg
AU  - Haukka, Jan
AU  - Pietinen, Pirjo
AU  - Taylor, Phil R.
AU  - Huttunen, Jussi K.
T1  - Toenail selenium as an indicator of selenium intake among middle-aged men in an area with low soil selenium.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/05//
VL  - 57
IS  - 5
M3  - Article
SP  - 662
EP  - 665
SN  - 00029165
AB  - Toenail selenium concentration has been proposed as a long-term (6-12 mo) indicator of human selenium status. This study investigated the association between toenail selenium concentration and selenium intake and other dietary factors among 166 urban men aged 55-69 y. The dietary information was collected by food records covering a 6-mo period. Toenail clippings were collected by mail 9-10 mo after food recording. The mean selenium intake from food was 42.5 and the dietary intake was equal to that of users and nonusers of selenium supplements. The mean toenail selenium concentration was 0.47 mg/kg. The mean selenium intake from supplements was 29.7 µg/d among supplement users. In the analysis of covariance the best predictors of toenail selenium concentration were selenium intake from supplements and food, and among supplement users dietary β-carotene also. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - Dietary supplements
KW  - Food consumption
KW  - Selenium in human nutrition
KW  - Middle-aged men
KW  - Carotene in the blood
KW  - diet
KW  - middle-aged men
KW  - Selenium intake
KW  - selenium supplements
KW  - toenail selenium
N1  - Accession Number: 94403144; Ovaskainen, Marja-Leena 1; Virtamo, Jarmo 1; Alfthan, Georg 1; Haukka, Jan 1; Pietinen, Pirjo 1; Taylor, Phil R. 1; Huttunen, Jussi K. 1; Affiliations: 1: National Cancer Institute, Bethesda, MD; Issue Info: May1993, Vol. 57 Issue 5, p662; Thesaurus Term: HEALTH; Thesaurus Term: Dietary supplements; Thesaurus Term: Food consumption; Subject Term: Selenium in human nutrition; Subject Term: Middle-aged men; Subject Term: Carotene in the blood; Author-Supplied Keyword: diet; Author-Supplied Keyword: middle-aged men; Author-Supplied Keyword: Selenium intake; Author-Supplied Keyword: selenium supplements; Author-Supplied Keyword: toenail selenium; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ho, Suzanne C.
AU  - Bacon, W. Edward
AU  - Harris, Tamara
AU  - Looker, Anne
AU  - Maggi, Stefania
T1  - Hip Fracture Rates in Hong Kong and the United States, 1988 through 1989.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/05//
VL  - 83
IS  - 5
M3  - Article
SP  - 694
EP  - 697
PB  - American Public Health Association
SN  - 00900036
AB  - OBJECTIVES. Prior studies have suggested that hip fracture rates are substantially lower in Asian countries than in the United States. However, comparisons have been limited by unavailability of recent data, differences in case definition, lack of data from similar time periods, and small sample sizes. This study sought to examine trends by age and sex, with separate statistics for those aged 85 or older. METHODS. Hospital discharge data were used to obtain hip fracture incidence in Hong Kong and the United States from 1988 through 1989. RESULTS. Within each population, women had higher hip fracture rates than men. Fracture rates in the United States were significantly higher for both sexes than rates in Hong Kong. For persons over the age of 80, rates of hip fracture among White US males exceeded those for Hong Kong women. Inclusion of transferred cases in hip fracture rates minimized differences between the countries. CONCLUSIONS. Despite increasing hip fracture rates in Hong Kong, those rates are still substantially lower than the rates in the United States. Identifying factors responsible for this variation may prove useful in the search for preventive strategies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIP joint -- Wounds & injuries
KW  - FRACTURES
KW  - WOUNDS & injuries
KW  - HONG Kong (China)
KW  - CHINA
N1  - Accession Number: 9307095125; Ho, Suzanne C. 1 Bacon, W. Edward 2 Harris, Tamara 2 Looker, Anne 2 Maggi, Stefania 3; Affiliation:  1: Department of Community and Family Medicine, Chinese University of Hong Kong  2: National Center for Health Statistics, Centers for Disease Control, Hyattsville, Md  3: WHO Research Program on Aging, National Institutes of Health, Bethesda, Md; Source Info: May93, Vol. 83 Issue 5, p694; Subject Term: HIP joint -- Wounds & injuries; Subject Term: FRACTURES; Subject Term: WOUNDS & injuries; Subject Term: HONG Kong (China); Subject Term: CHINA; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wong, Ma-Li
AU  - Licinio, Júlio
AU  - Gold, Philip W.
AU  - Glowa, John
T1  - Activity-Induced Anorexia in Rats does not Affect Hypothalamic Neuropeptide Gene Expression Chronically.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993/05//
VL  - 13
IS  - 4
M3  - Article
SP  - 399
EP  - 405
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Hypothalamic neuropeptides are though to contribute to the pathophysiology of eating disorders. In an animal model with chromic abnormalities of energy expenditure, appetitive behavior, and body weight, without acute food restriction, we found alterations in peripheral levels of adrenocorticotropic hormone and corticosterone, but no alterations in the expressions of neuropeptides genes that are known to regulate ingestive behavior and food intake acutely. Our data suggest that activation of hypothalamic-pituitary-adrenal function in activity anorexia may not be due to increased transcription of corticotropin-releasing hormone gene, but might be related to posttranscriptional events or to other neuropeptides, such as arginine vasopressin. Furthermore, we suggest that abnormalities in neuropeptides observed in eating disorders may be caused by acute food restriction, rather than by chronic hyperactivity, anorexia, and low weight [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EATING disorders
KW  - PATHOLOGICAL physiology
KW  - HYPOTHALAMIC hormones
KW  - NEUROPEPTIDES
KW  - APPETITE loss
KW  - FOOD
KW  - GENES
KW  - HEREDITY
N1  - Accession Number: 11955019; Wong, Ma-Li 1 Licinio, Júlio 2 Gold, Philip W. 3 Glowa, John 4; Affiliation:  1: Instructor in Psychiatry, Yale University School  of Medicine  2: Assistant Professor of Psychiatry, Yale University School of Medicine  3: Chief, Clinical Neuroendocrinology Branch, National Institute of Mental Health  4: Research Scientist, National Institute of Diabetes; Source Info: May1993, Vol. 13 Issue 4, p399; Subject Term: EATING disorders; Subject Term: PATHOLOGICAL physiology; Subject Term: HYPOTHALAMIC hormones; Subject Term: NEUROPEPTIDES; Subject Term: APPETITE loss; Subject Term: FOOD; Subject Term: GENES; Subject Term: HEREDITY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chitnis, Chetan E.
AU  - Ohman, Dennis E.
T1  - Genetic analysis of the alginate biosynthetic gene cluster of Pseudomonas aeruginosa shows evidence of an operonic structure.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/05//
VL  - 8
IS  - 3
M3  - Article
SP  - 583
EP  - 590
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Strains of <em>Pseudomonas aeruginosa</em> causing pulmonary infections in cystic fibrosis patients have an unusual mucoid phenotype because of production of the capsule-like exopolyseccharide, alginate. Transcriptional activation of <em>algD</em>, the first gene of a large alginate biosynthetic gene cluster, is associated with conversion to the alginate-producing (Alg+) phenotype. In this study, we examined the regulation of alginate genes immediately downstream of <em>algD</em>. Mutants of the Alg+ strain FRD1 were constructed by gene replacement with defined <em>Tn501</em> (8.2kb) insertions in the alginate biosynthetic gene cluster, resulting in an Alg- phenotype. The Alg+ phenotype of these mutants was restored by integration of narrow-host-range plasmids containing DNA fragments from <em>P. aeruginosa</em> that reconstructed a continuous alginate gene cluster. A broad-host-range plasmid containing the entire alginate gene cluster except for the terminal gene, <em>algA</em>, was unable to complement an <em>alG</em>::Tn<em>501</em> mutant unless <em>algA</em> was transcribed from a second plasmid. This indicated that any Tn<em>501</em> insertion in the cluster was polar on downstream alginate genes. Northern blot hybridization experiments also showed that a transposon insertion downstream of <em>algD</em> adversely affected <em>algG</em> and <em>algA</em> transcription. These results provided evidence that the alginate biosynthetic gene cluster has an operonic structure and is cotranscribed from the <em>algD</em> promoter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Genetics
KW  - Alginates
KW  - Microbial polysaccharides
KW  - Pseudomonas aeruginosa
KW  - Pseudomonas
KW  - Operons
N1  - Accession Number: 16064850; Chitnis, Chetan E. 1,2; Ohman, Dennis E. 3,4; Affiliations: 1: Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA; 2: Laboratory of Malaria Research, National Institutes of Health, Building 4, Bethesda, Maryland 20892, USA; 3: Department of Microbiology and Immunology, University of Tennessee, Tennessee; 4: Veterans Administration Medical Center, Memphis, Tennessee 38163, USA; Issue Info: May1993, Vol. 8 Issue 3, p583; Thesaurus Term: Genetics; Subject Term: Alginates; Subject Term: Microbial polysaccharides; Subject Term: Pseudomonas aeruginosa; Subject Term: Pseudomonas; Subject Term: Operons; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Illustrations: 4 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-06472-015
AN  - 2006-06472-015
AU  - Cole, Pamela M.
T1  - The Emotion Renaissance: Views from Early Childhood.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1993/05//
VL  - 38
IS  - 5
SP  - 481
EP  - 482
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06472-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Cole, Pamela M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Emotional Control; Emotional Development; Emotions; Psychosocial Development. Minor Descriptor: Developmental Psychology. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Eisenberg, Nancy (Ed); Fabes, Richard A. (Ed). Emotion and its Regulation in Early Development=San Francisco: Jossey-Bass, 1992. 110 pp. $17.95 paperback; 1992. Page Count: 2. Issue Publication Date: May, 1993. 
AB  - Reviews the book, Emotion and its Regulation in Early Development edited by Nancy Eisenberg and Richard A. Fabes (see record [rid]1992-97569-000[/rid]). The primary goal of the editors is to present empirical work that demonstrates how the study of emotional development has transformed research on the major topics within developmental psychology, including cognitive, physical, and social development. In so doing, they attempt to debunk two ideas--the classical view of emotions as irrational forces requiring subjugation by the maturing individual and the view that emotions are mainly intrapsychic phenomena. In summary, the volume is stocked with interesting original works and provides many points of departure for discussion and research ideas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - emotional development
KW  - developmental psychology
KW  - emotional regulation
KW  - emotions
KW  - 1993
KW  - Emotional Control
KW  - Emotional Development
KW  - Emotions
KW  - Psychosocial Development
KW  - Developmental Psychology
KW  - 1993
U2  - Eisenberg, Nancy (Ed); Fabes, Richard A. (Ed). (1992); Emotion and its Regulation in Early Development; San Francisco: Jossey-Bass, 1992. 110 pp. $17.95 paperback; 1-55542-751-0 (Paperback).
DO  - 10.1037/033305
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-20220-001
AN  - 2015-20220-001
AU  - Giambra, Leonard M.
T1  - The influence of aging on spontaneous shifts of attention from external stimuli to the contents of consciousness.
JF  - Experimental Gerontology
JO  - Experimental Gerontology
JA  - Exp Gerontol
Y1  - 1993/05//
VL  - 28
SP  - 485
EP  - 492
CY  - Netherlands
PB  - Elsevier Science
SN  - 0531-5565
AD  - Giambra, Leonard M., Gerontology Research Center, National Institute on Aging, Francis Scott Key Medical Center, 4940 Eastern Avenue, Baltimore, MD, US, 21224
N1  - Accession Number: 2015-20220-001. PMID: 8224044 Partial author list: First Author & Affiliation: Giambra, Leonard M.; Gerontology Research Center, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, MD, US. Release Date: 20150518. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Aging; Attention; Daydreaming. Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Sustained Attention Task; Daydreaming Frequency Scale of the Imaginal Processes Inventory; Daydreaming Frequency Scale [Appended]. Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 1993. Copyright Statement: Pergamon Press Ltd. 1993. 
AB  - Abstract—ln a series of studies using laboratory procedures and retrospective reports it has been established that with increasing age adults less frequently have unbidden task-unrelated image and thought intrusions (TUITs). TUITs—also referred to as daydreams—have been linked to the 'current concerns' and 'unfinished business' of the individual, and old adults have been shown to express fewer current concerns than young adults. It has also been hypothesized that selective loss of neurons in old age might interfere with thought production, resulting in fewer unbidden thoughts and spontaneous shifts of attention to them. In this article we examine the extent to which intraindividual change in the frequency of TUITs over 6 to 8 years is consistent with the decrease expected from the prior cross-sectional studies. In particular, we examine the frequency of daydreams based upon retrospective self-reports using the Daydreaming Frequency scale of the Imaginal Processes Inventory. The longitudinal sample consisted of 93 women and 169 men. Significant and equivalent decreases in Daydreaming Frequency scale values occurred at all ages. Longitudinal decreases were consistent with cross-sectional age differences. Thus, spontaneous shifts of attention to the contents of consciousness were seen to decrease over a 6 to 8 year interval within individuals—a result consistent with a within-individual change in conditions leading to spontaneous shifts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aging
KW  - spontaneous attentional shifts
KW  - daydreaming
KW  - concentration
KW  - longitudinal change
KW  - 1993
KW  - Age Differences
KW  - Aging
KW  - Attention
KW  - Daydreaming
KW  - 1993
DO  - 10.1016/0531-5565(93)90073-M
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-34982-008
AN  - 2015-34982-008
AU  - Hunter, Chyren
AU  - Petralia, Ronald S.
AU  - Vu, Thuc
AU  - Wenthold, Robert J.
T1  - Expression of AMPA-selective glutamate receptor subunits in morphologically defined neurons of the mammalian cochlear nucleus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1993/05//
VL  - 13
IS  - 5
SP  - 1932
EP  - 1946
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Hunter, Chyren, Section on Neurotransmitter Receptor Biology, Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Building 36, Room 5D08, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-34982-008. PMID: 7683046 Partial author list: First Author & Affiliation: Hunter, Chyren; Section on Neurotransmitter Receptor Biology, Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: NATO Advanced Research Workshop on the Mammalian Cochlear Nuclei: Organization and Function, Sep, 1991. Conference Note: Parts of this article were presented in preliminary form at the aforementioned conference. Major Descriptor: Acoustic Nerve; Auditory Cortex; Cells (Biology); Glutamate Receptors; mRNA. Minor Descriptor: Rats. Classification: Physiological Processes (2540). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 15. Issue Publication Date: May, 1993. Publication History: Accepted Date: Nov 10, 1992; Revised Date: Nov 5, 1992; First Submitted Date: Aug 25, 1992. Copyright Statement: Society for Neuroscience. 1993. 
AB  - Glutamate and related amino acids mediate fast excitatory neurotransmission in the vertebrate CNS via ligand-gated cationic channels in the neuronal membrane. These channels are composed of different subunits that assemble into a functional receptor/channel complex. Although studies have shown that these subunits are differentially expressed in neurons, few studies have quantitatively addressed the cell-specific expression of glutamate subunits in relation to known glutamatergic pathways. In the vertebrate auditory system, glutamate is the proposed neurotransmitter of the auditory nerve and parallel fiber pathways. In situ hybridization histochemistry was used to localize AMPA-selective glutamate receptor subunit mRNAs in seven cell types of the rat cochlear nucleus. GluR1-GluR4 AMPA-selective subunits were all expressed in cochlear nucleus neurons; however, the subunits expressed in identified cells varied with the cell type. Granule cells, previously not known to receive glutamatergic input, expressed GluR2 and GluR4 subunits. Cartwheel and stellate interneurons in the dorsal cochlear nucleus, which receive parallel fiber input, expressed all four subunits. Neurons receiving synaptic input from the auditory nerve, including globular, round, spherical, and fusiform cells, expressed GluR2, GluR3, and GluR4 subunits. Furthermore, a subpopulation of round cells in the ventral cochlear nucleus, and fusiform cells in the dorsal cochlear nucleus, expressed the GluR3 subunit at greatly reduced levels compared to neighboring cells. The results confirm the auditory nerve and parallel fiber pathways as glutamatergic and identify a third synaptic population, projecting to granule cells, which is likely glutamatergic. The data suggest that the composition of GluR1-GluR4 subunits on neurons in the cochlear nucleus may be related to presynaptic input; moreover, heterogeneous patterns of expression of the GluR3 subunit, in addition, suggest that variability in mRNA levels within one population of morphologically defined cells is present. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptor
KW  - in situ hybridization
KW  - cochlear nucleus
KW  - rat
KW  - auditory system
KW  - cell-specific mRNA
KW  - 1993
KW  - Acoustic Nerve
KW  - Auditory Cortex
KW  - Cells (Biology)
KW  - Glutamate Receptors
KW  - mRNA
KW  - Rats
KW  - 1993
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Swinburn, Boyd
AU  - Ravussin, Eric
T1  - Energy balance or fat balance?
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/05/02/May1993 Supplement
M3  - Article
SP  - 766S
EP  - 771S
SN  - 00029165
AB  - Under normal conditions, carbohydrate, protein, and alcohol are not converted to fat. Glycogen and protein stores are closely controlled, and increasing the intake of nonfat nutrients stimulates their oxidation rates proportionally. Thus. chronic imbalance between intake and oxidation of nonfat nutrients cannot lead to obesity. On the other hand, fat stores are not controlled and their capacity for expansion is enormous. Because an increase in fat intake does not stimulate fat oxidation, a positive fat balance results, which has the potential to become chronic. Obesity is therefore due to a long-standing positive fat balance, which may simply be due to a high-fat diet. The use of the fat-balance equation instead of the energy-balance equation adds another option for the treatment of obesity-that of changing the quality of the diet, ie. lowering the fat content. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bioenergetics
KW  - Adipose tissues
KW  - Carbohydrates
KW  - Proteins in the body
KW  - Obesity -- Physiological aspects
KW  - Indirect calorimetry
KW  - dietary fat
KW  - indirect calorimetry
KW  - Obesity
KW  - weight loss
N1  - Accession Number: 94403175; Swinburn, Boyd 1,2; Ravussin, Eric 1,2; Affiliations: 1: Department of Community Health, School of Medicine, University of Auckland, New Zealand; 2: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix; Issue Info: May1993 Supplement, p766S; Thesaurus Term: Bioenergetics; Subject Term: Adipose tissues; Subject Term: Carbohydrates; Subject Term: Proteins in the body; Subject Term: Obesity -- Physiological aspects; Subject Term: Indirect calorimetry; Author-Supplied Keyword: dietary fat; Author-Supplied Keyword: indirect calorimetry; Author-Supplied Keyword: Obesity; Author-Supplied Keyword: weight loss; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107299725
T1  - Multiple myeloma. New approaches to therapy.
AU  - Dunbar CE
AU  - Neinhuis AW
AU  - Dunbar, C E
AU  - Nienhuis, A W
Y1  - 1993/05/12/
N1  - Accession Number: 107299725. Language: English. Entry Date: 19981201. Revision Date: 20161112. Publication Type: journal article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Multiple Myeloma -- Therapy
KW  - Female
KW  - Middle Age
SP  - 2412
EP  - 2416
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 269
IS  - 18
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Md, National Institutes of Health 20892
AD  - Hematology Branch, National Heart, Lung, and Blood Institute, Bldg 10, Room 7C-103, National Institute of Health, Bethesda, Md 20892
U2  - PMID: 7683062.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Koonin, Eugene V.
T1  - Bacterial and bacteriophage protein phosphatases.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/05/15/
VL  - 8
IS  - 4
M3  - Letter
SP  - 785
EP  - 786
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Presents a letter to the editor about bacterial and bacteriophage protein phosphatases.
KW  - Phosphatases
KW  - Letters to the editor
N1  - Accession Number: 16065052; Koonin, Eugene V. 1; Affiliations: 1: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, Maryland 20894, USA; Issue Info: May1993, Vol. 8 Issue 4, p785; Thesaurus Term: Phosphatases; Subject Term: Letters to the editor; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Battjes, Robert J.
AU  - Haverkos, Harry W.
T1  - Cocaine, AIDS, and Intravenous Drug Use.
JO  - AIDS Education & Prevention
JF  - AIDS Education & Prevention
Y1  - 1993///Summer1993
VL  - 5
IS  - 2
M3  - Book Review
SP  - 178
EP  - 179
SN  - 08999546
AB  - The article reviews the book "Cocaine, AIDS, and Intravenous Drug Use," edited by Samuel R. Friedman and Douglas S. Lipton.
KW  - Drug abuse
KW  - Nonfiction
KW  - Friedman, Samuel R.
KW  - Lipton, Douglas S.
KW  - Cocaine, AIDS & Intravenous Drug Use (Book)
N1  - Accession Number: 19600222; Battjes, Robert J. 1; Haverkos, Harry W. 1; Affiliations: 1: National Institute on Drug Abuse Rockville, MD.; Issue Info: Summer1993, Vol. 5 Issue 2, p178; Subject Term: Drug abuse; Subject Term: Nonfiction; Reviews & Products: Cocaine, AIDS & Intravenous Drug Use (Book); People: Friedman, Samuel R.; People: Lipton, Douglas S.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Barr, Robin
T1  - SUCCESSFUL AGING: PERSPECTIVES FROM THE BEHAVIORAL SCIENCES (Book).
JO  - Applied Cognitive Psychology
JF  - Applied Cognitive Psychology
Y1  - 1993/06//
VL  - 7
IS  - 3
M3  - Book Review
SP  - 272
EP  - 274
PB  - John Wiley & Sons, Inc.
SN  - 08884080
AB  - Reviews the book "Successful Aging: Perspective From the Behavioral Sciences," edited by P. B. Baltes and M. M. Baltes.
KW  - AGING -- Psychological aspects
KW  - NONFICTION
KW  - BALTES, M. M.
KW  - BALTES, P. B.
KW  - SUCCESSFUL Aging (Book)
N1  - Accession Number: 12007402; Barr, Robin 1; Affiliation:  1: National Institute of Aging, Bethesda, MD; Source Info: Jun93, Vol. 7 Issue 3, p272; Subject Term: AGING -- Psychological aspects; Subject Term: NONFICTION; Reviews & Products: SUCCESSFUL Aging (Book); People: BALTES, M. M.; People: BALTES, P. B.; Number of Pages: 3p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Maurea, Simone
AU  - Cuocolo, Alberto
AU  - Pace, Leonardo
AU  - Nicolai, Emanuele
AU  - Nappi, Antonio
AU  - Imbriaco, Massimo
AU  - Morisco, Carmine
AU  - Chiariello, Massimo
AU  - Trimarco, Bruno
AU  - Salvatore, Marco
T1  - Rest-injected thallium-201 redistribution and resting technetium-99m methoxyisobutylisonitrile uptake in coronary artery disease: relation to the severity of coronary artery stenosis.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1993/06//
VL  - 20
IS  - 6
M3  - Article
SP  - 502
EP  - 510
SN  - 03406997
N1  - Accession Number: 71145752; Maurea, Simone 1 Cuocolo, Alberto 1 Pace, Leonardo 1 Nicolai, Emanuele 1 Nappi, Antonio 1 Imbriaco, Massimo 1 Morisco, Carmine 2 Chiariello, Massimo 3 Trimarco, Bruno 2 Salvatore, Marco 4; Affiliation:  1: Department of Nuclear Medicine, University Federico II, Napoli Italy  2: Department of Internal Medicine, University Federico II, Napoli Italy  3: Department of Cardiology, University Federico II, Napoli Italy  4: National Cancer Institute, Napoli Italy; Source Info: Jun1993, Vol. 20 Issue 6, p502; Number of Pages: 9p; Document Type: Article
L3  - 10.1007/BF00175163
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - King, Haitung
T1  - Entry Denied, Exclusion and the Chinese Community in America, 1882-1943 (Book).
JO  - International Migration Review
JF  - International Migration Review
Y1  - 1993///Summer93
VL  - 27
IS  - 2
M3  - Book Review
SP  - 434
EP  - 435
SN  - 01979183
AB  - Reviews the book "Entry Denied, Exclusion and the Chinese Community in America, 1882-1943," edited by Sucheng Chang.
KW  - CHINESE Americans
KW  - NONFICTION
KW  - SUCHENG Chan
KW  - ENTRY Denied, Exclusion & the Chinese Community in America, 1882-1943 (Book)
N1  - Accession Number: 9312031906; King, Haitung 1; Affiliation:  1: National Cancer Institute and Georgetown University School of Medicine; Source Info: Summer93, Vol. 27 Issue 2, p434; Subject Term: CHINESE Americans; Subject Term: NONFICTION; Reviews & Products: ENTRY Denied, Exclusion & the Chinese Community in America, 1882-1943 (Book); People: SUCHENG Chan; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bray, James H.
AU  - Hetherington, E. Mavis
T1  - Families in Transition: Introduction and Overview.
JO  - Journal of Family Psychology
JF  - Journal of Family Psychology
Y1  - 1993/06//
VL  - 7
IS  - 1
M3  - Article
SP  - 3
EP  - 8
SN  - 08933200
AB  - The article discusses various papers on families in transition published within this issue, including one by Gottman on marital process and another by Hetherington on the Virginia Longitudinal Study of Divorce and Remarriage.
KW  - PREFACES & forewords
KW  - FAMILIES
N1  - Accession Number: 24701250; Bray, James H. 1 Hetherington, E. Mavis 2; Affiliation:  1: Department of Family Medicine, Baylor College of Medicine; E. Mavis Hetherington, Department of Psychology, University of Virginia  2: National Institute of Child Health and Human Development; Source Info: Jun93, Vol. 7 Issue 1, p3; Subject Term: PREFACES & forewords; Subject Term: FAMILIES; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Trickett, Penelope K.
T1  - Maladaptive Development of School-Aged, Physically Abused Children: Relationships With the Child-Rearing Context.
JO  - Journal of Family Psychology
JF  - Journal of Family Psychology
Y1  - 1993/06//
VL  - 7
IS  - 1
M3  - Article
SP  - 134
EP  - 147
SN  - 08933200
AB  - This research examined the development of school-aged, physically abused children and the relationship of this development to the child-rearing beliefs and practices of the abusive parents. The sample consisted of 29 physically abused children between the ages of 4 and 11 and their parents and a comparison group of 29 families matched on age, race, and gender of the child and family socioeconomic status. A multimethod approach including interviews, standardized tests, Q sorts, parent record keeping, and structured observation was used to assess the cognitive, social, and physical competence and behavior problems of the children and the child-rearing context of the homes. The abused children had poorer cognitive maturity, interpersonal problem-solving skills, and social competence and many more behavior problems than the comparison children. In some instances, aspects of the child-rearing context were stronger predictors of the children's development than was abuse group membership. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ABUSED children
KW  - CHILD rearing
KW  - ABUSIVE parents
KW  - PARENT & child
KW  - DOMESTIC relations
KW  - FAMILIES
N1  - Accession Number: 24701259; Trickett, Penelope K. 1; Affiliation:  1: Laboratory of Developmental Psychology, National Institute of Mental Health; Source Info: Jun93, Vol. 7 Issue 1, p134; Subject Term: ABUSED children; Subject Term: CHILD rearing; Subject Term: ABUSIVE parents; Subject Term: PARENT & child; Subject Term: DOMESTIC relations; Subject Term: FAMILIES; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Steinert, Peter M.
T1  - Structure, Function, and Dynamics of Keratin Intermediate Filaments.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/06//
VL  - 100
IS  - 6
M3  - Article
SP  - 729
EP  - 734
SN  - 0022202X
AB  - All mammalian cells contain a complex cytoskeleton composed of three principal structural proteins and their associated proteins, actin-containing microfilaments, tubulin-containing microtubules and intermediate filaments (IF). Of these, IF are the most complex in terms of the numbers of protein chains. The recent widespread application of modern methods of structural biology, molecular biology and molecular genetics has provided a wealth of new information on the structure and function of the KIF of the epidermis. One of the more surprising aspects of this work has been the realization of the dynamic behavior of the KIF in living cells.
KW  - CYTOSKELETON
KW  - EPITHELIUM
KW  - MAMMALS
KW  - GENETICS
KW  - KERATIN
KW  - CELLS
N1  - Accession Number: 12475665; Steinert, Peter M. 1; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jun93, Vol. 100 Issue 6, p729; Subject Term: CYTOSKELETON; Subject Term: EPITHELIUM; Subject Term: MAMMALS; Subject Term: GENETICS; Subject Term: KERATIN; Subject Term: CELLS; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12475665
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12475665&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yarosh, Daniel B.
AU  - Alas, Lori
AU  - Kibitel, Jeannie
AU  - O'Connor, Adrienne
AU  - Carrier, France
AU  - Fornace Jr., Albert J.
T1  - Cyclobutane Pyrimidine Dimers in UV-DNA Induce Release of Soluble Mediators that Activate the Human Immunodeficiency Virus Promoter.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/06//
VL  - 100
IS  - 6
M3  - Article
SP  - 790
EP  - 794
SN  - 0022202X
AB  - Ultraviolet (UV) irradiation of human cells induced expression of a stably maintained fusion gene consisting of the human immunodeficiency virus long terminal repeat promoter controlling the bacterial chloramphenicol acetyltransferase gene. Two experiments demonstrated that DNA damage can initiate induction: UV induction was greater in DNA repair-deficient cells from a xeroderma pigmentosum patient than in repair-proficient cells, and transfection of UV-irradiated DNA into unirradiated cells activated gene expression. Increased repair of cyclobutane pyrimidine dimers by T4 endonuclease V abrogated viral gene activation, suggesting that dimers in DNA are one signal leading to increased gene expression. This signal was spread from UV-irradiated cells to unirradiated cells by co-cultivation, implicating the release of soluble factors. Irradiation of cells from DNA repair-deficiency diseases resulted in greater release of soluble factors than irradiation of cells from unaffected individuals. These results suggest that UV-induced cyclobutane pyrimidine dimers can activate the human immunodeficiency virus promoter at least in part by a signal-transduction pathway that includes secretion of soluble mediators. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PYRIMIDINES
KW  - IRRADIATION
KW  - CELLS
KW  - DNA
KW  - GENES
KW  - BIOCHEMICAL genetics
N1  - Accession Number: 12476573; Yarosh, Daniel B. 1 Alas, Lori 1 Kibitel, Jeannie 1 O'Connor, Adrienne 1 Carrier, France 2 Fornace Jr., Albert J. 2; Affiliation:  1: Applied Genetics Inc., Freeport, New York.  2: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, U.S.A..; Source Info: Jun93, Vol. 100 Issue 6, p790; Subject Term: PYRIMIDINES; Subject Term: IRRADIATION; Subject Term: CELLS; Subject Term: DNA; Subject Term: GENES; Subject Term: BIOCHEMICAL genetics; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12476573
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12476573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bergeman, C. S.
AU  - Chipuer, Heather M.
AU  - Plomin, Robert
AU  - Pedersen, Nancy L.
AU  - McClearn, G. E.
AU  - Nesselroade, John R.
AU  - Costa Jr., Paul T.
AU  - McCrae, Robert R.
T1  - Genetic and Environmental Effects on Openness to Experience, Agreeableness, and Conscientiousness: An Adoption/Twin Study.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1993/06//
VL  - 61
IS  - 2
M3  - Article
SP  - 159
EP  - 179
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Previous research has indicated that extraversion and neuroticism are substantially affected both by genotype and environment. This study assesses genetic and environmental influences on the other three components of the five-factor model of personality: Openness to Experience, Agreeableness, and Conscientiousness. An abbreviated version of the NEO Personality Inventory (NEO-PI) was administered to 82 pairs of identical twins and 171 pairs of fraternal twins reared apart and 132 pairs of identical twins and 167 pairs of fraternal twins reared together. Estimates of genetic and environmental effects for Openness and Conscientiousness were similar to those found in other studies of personality: Genetic influence was substantial and there was little evidence of shared rearing environment. Results for Agreeableness were different: Genetic influence accounted for only 12% of the variance and shared rearing environment accounted for 21% of the variance. Few significant gender or age differences for genetic and environmental parameters were found in model-fitting analyses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXTRAVERSION
KW  - NEUROTICS
KW  - GENOTYPE-environment interaction
KW  - GENETICS
KW  - PERSONALITY
KW  - NEO Personality Inventory
N1  - Accession Number: 9308266336; Bergeman, C. S. 1 Chipuer, Heather M. 2 Plomin, Robert 2 Pedersen, Nancy L. 2,3 McClearn, G. E. 2 Nesselroade, John R. 2 Costa Jr., Paul T. 4 McCrae, Robert R. 4; Affiliation:  1: Department of Psychology, University of Notre Dame  2: College of Health and Human Development, Pennsylvania State University  3: Department of Environmental Hygiene, The Karolinska Institute, Stockholm, Sweden  4: Gerontology Research Center, National Institute on Aging, NIH; Source Info: Jun93, Vol. 61 Issue 2, p159; Subject Term: EXTRAVERSION; Subject Term: NEUROTICS; Subject Term: GENOTYPE-environment interaction; Subject Term: GENETICS; Subject Term: PERSONALITY; Subject Term: NEO Personality Inventory; Number of Pages: 21p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3  - 10.1111/1467-6494.ep9308266336
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9308266336&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Graubard, Barry I.
AU  - Korn, Edward L.
AD  - National Cancer Institute
AD  - National Cancer Institute
T1  - Hypothesis Testing with Complex Survey Data: The Use of Classical Quadratic Test Statistics with Particular Reference to Regression Problems
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1993/06//
VL  - 88
IS  - 422
SP  - 629
EP  - 641
SN  - 01621459
N1  - Accession Number: 0294712; Keywords: Regression; Publication Type: Journal Article; Update Code: 199312
KW  - Single Equation Models; Single Variables: General          C20
L3  - http://amstat.tandfonline.com/loi/uasa20
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0294712&site=ehost-live&scope=site
UR  - http://amstat.tandfonline.com/loi/uasa20
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
T1  - Laterality for music perception in musicians, mathematicians, and dancers: jumping to conclusions. / Lateralite dans la perception de la musique chez des musiciens, des mathematiciens et des danseurs: conclusions.
AU  - Gordon, H.W.
JO  - Perceptual & Motor Skills
JF  - Perceptual & Motor Skills
Y1  - 1993/06//
VL  - 76
IS  - 3 part 1
SP  - 941
EP  - 942
CY  - ; 
SN  - 00315125
N1  - Accession Number: SPHS-948648; Author: Gordon, H.W.: 1 ; Author Affiliation: 1 National Institute on Drug Abuse, Rockwall II - Suite 615, 5600 Fishers Lane, Rockville, MD 20857, United States; No. of Pages: 2; Language: English; Parent Item: SPHP914; References: 8; General Notes: INSEP, PARIS. Cote: PE 51. Acces: copie. K5.7 - NEUROPHYSIOLOGIE / L18 - DANSE ET EXPRESSION CORPORELLE.; Publication Type: Article; Update Code: 20040901; SIRC Article No.: S-948648
N2  - Group differences for ear asymmetries for a melodies task were reported for talented music, mathematics, and dance students. Evidence is presented that it is premature to conclude that these group differences were the result of specialized training in their areas of expertise.
KW  - *DANCE
KW  - *HEARING
KW  - *CEREBRAL dominance
KW  - MUSIC
KW  - RHYTHM
KW  - HUMAN information processing
KW  - COMPARATIVE studies
KW  - DOMINANCE-CEREBRALE
KW  - AUDITION
KW  - PERCEPTION-AUDITIVE
KW  - MUSIQUE
KW  - RYTHME
KW  - DANSE
KW  - TRAITEMENT-DE-L-INFORMATION
L2  - http://articles.sirc.ca/search.cfm?id=S-948648
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=SPHS-948648&site=ehost-live&scope=site
UR  - http://articles.sirc.ca/search.cfm?id=S-948648
DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2006-06473-038
AN  - 2006-06473-038
AU  - Bornstein, Marc H.
T1  - Infancy, Parenting, and Culture.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1993/06//
VL  - 38
IS  - 6
SP  - 616
EP  - 618
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06473-038. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bornstein, Marc H.; National Institute of Child Health and Human Development, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cross Cultural Differences; Dyads; Infant Development; Parent Child Relations; Parenting Skills. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Nugent, J. Kevin (Ed); Lester, Barry M. (Ed); Brazelton, T. Berry (Ed). The Cultural Context of Infancy, Vol. 2: Multicultural and Interdisciplinary Approaches to Parent-Infant Relations=Norwood, NJ: Ablex, 1991. 369 pp. $67.50 (institutional), $37.50 (individual); 1991. References Available: Y. Page Count: 3. Issue Publication Date: Jun, 1993. 
AB  - Reviews the book, The Cultural Context of Infancy, Vol. 2: Multicultural and Interdisciplinary Approaches to Parent-Infant Relations edited by J. Kevin Nugent, Barry M. Lester, T. Berry Brazelton (see record [rid]1991-98572-000[/rid]). Infants vary in the breadth, style, and organization of their behaviors nearly as much as possible. Multicultural and Interdisciplinary Approaches to Parent-Infant Relations is Volume 2 of the Cultural Context of Infancy series. Volume 2 is divided into three parts (each with 3-4 chapters) concerned serially with newborn behavior and later development, mother interaction in context, and cultural perspectives on the high-risk infant and family. More particularly, contributions in this volume cross the Neonatal Behavioral Assessment Scale (as indicative of infant status and behavioral organization) with culture, with the aim of elucidating these several topics. Thus, the contributions in this volume do not report cross-cultural studies per se, but empirical investigations of newborn performance and its implications and interactions with parenting contextualized by culture. The present volume aims to broaden traditional examinations of the nature of maternal behaviors in the period of the dyad's initial accommodation by including interactions of mothers with their infants across diverse cultural settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - infancy
KW  - parenting
KW  - culture
KW  - parent-infant relations
KW  - 1993
KW  - Cross Cultural Differences
KW  - Dyads
KW  - Infant Development
KW  - Parent Child Relations
KW  - Parenting Skills
KW  - 1993
U2  - Nugent, J. Kevin (Ed); Lester, Barry M. (Ed); Brazelton, T. Berry (Ed). (1991); The Cultural Context of Infancy, Vol. 2: Multicultural and Interdisciplinary Approaches to Parent-Infant Relations; Norwood, NJ: Ablex, 1991. 369 pp. $67.50 (institutional), $37.50 (individual); 0-89391-627-7.
DO  - 10.1037/033418
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06473-038&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-34987-026
AN  - 2015-34987-026
AU  - Dawson, Valina L.
AU  - Dawson, Ted M.
AU  - Bartley, Duane A.
AU  - Uhl, George R.
AU  - Snyder, Solomon H.
T1  - Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1993/06//
VL  - 13
IS  - 6
SP  - 2651
EP  - 2661
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Snyder, Solomon H., Department of Neuroscience, 725 North Wolfe Street, Baltimore, MD, US, 21205
N1  - Accession Number: 2015-34987-026. PMID: 7684776 Partial author list: First Author & Affiliation: Dawson, Valina L.; National Institute on Drug Abuse, Addiction Research Center, Laboratory of Molecular Neurobiology, Baltimore, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Snyder, Solomon H. Major Descriptor: Glutamic Acid; N-Methyl-D-Aspartate; Nitric Oxide; Neurodegeneration. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Jun, 1993. Publication History: Accepted Date: Jan 11, 1993; Revised Date: Jan 4, 1993; First Submitted Date: Oct 5, 1992. Copyright Statement: Society for Neuroscience. 1993. 
AB  - In addition to mediating several physiological functions, nitric oxide (NO) has been implicated in the cytotoxicities observed following activation of macrophages or excess stimulation of neurons by glutamate. We extend our previous observations of glutamate-stimulated, NO-mediated neurotoxicity in primary cultures of rat fetal cortical, striatal, and hippocampal neurons. Neurotoxicity elicited by either NMDA or sodium nitroprusside (SNP) exhibits a similar concentration- effect relationship and time course. The concentration-effect curve of NMDA-induced neurotoxicity is shifted to the right in the presence of nitro-L-arginine and farther to the right in arginine-free media. The rank order of potency of several NO synthase (NOS) inhibitors in preventing neurotoxicity is the same as the rank order of these compounds in inhibiting NOS, and this inhibition is stereospecific. NMDA neurotoxicity is also prevented by flavoprotein Inhibitors and calmodulin inhibitors, fitting with the roles of flavoproteins and calmodulin as NOS regulators. 8-Bromo-cGMP and guanylyl cyclase inhibitors do not affect neurotoxicity, while superoxide dismutase attenuates neurotoxicity. NOS neurons appear to be the source of neurotoxic NO in culture, as lesions of these neurons with 20 μM quisqualate diminish subsequent NMDA neurotoxicity. Moreover, NMDA neurotoxicity develops over time in culture coincident with the expression of NOS. lmmunohistochemical localization of NOS in cultures and intact brain demonstrates widespread distribution of the cell processes suggesting that NOS neurons contact the majority of cortical neurons and so could mediate widespread neurotoxicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - NADPH-diaphorase
KW  - glutamate
KW  - NMDA
KW  - nitric oxide synthase
KW  - excitotoxicity
KW  - neurodegeneration
KW  - 1993
KW  - Glutamic Acid
KW  - N-Methyl-D-Aspartate
KW  - Nitric Oxide
KW  - Neurodegeneration
KW  - Rats
KW  - 1993
U1  - Sponsor: USPHS, US. Grant: MH-18501; DA-00266; DA 271-90-7408; DA-00074. Other Details: Research Scientist Award. Recipients: Snyder, Solomon H.
U1  - Sponsor: National Institutes of Health, National Institute of General Medical Sciences, US. Other Details: Pharmacology Research Associate Training Program and an Intramural Research Training Award (IRTA). Recipients: Dawson, Valina L.
U1  - Sponsor: American Academy of Neurology, US. Recipients: Dawson, Ted M.
U1  - Sponsor: French Foundation for Alzheimer’s Research, France. Recipients: Dawson, Ted M.
U1  - Sponsor: DANA Foundation. Recipients: Dawson, Ted M.
U1  - Sponsor: USPHS, US. Grant: CIDA NS 01578-01. Recipients: Dawson, Ted M.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-34987-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107470174
T1  - Smoking and lung function in elderly men and women. The Cardiovascular Health Study.
AU  - Higgins MW
AU  - Enright PL
AU  - Kronmal RA
AU  - Schenker MB
AU  - Anton-Culver H
AU  - Lyles M
AU  - Higgins, M W
AU  - Enright, P L
AU  - Kronmal, R A
AU  - Schenker, M B
AU  - Anton-Culver, H
AU  - Lyles, M
Y1  - 1993/06/02/
N1  - Accession Number: 107470174. Language: English. Entry Date: 19930801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Petty T L. It's never too late to stop smoking. But how old are your lungs? (JAMA) 6/2/93; 269 (21): 2785-2785. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: N01-87086//PHS HHS/United States. NLM UID: 7501160. 
KW  - Smoking -- In Old Age
KW  - Respiratory Function Tests -- In Old Age
KW  - Respiration -- In Old Age
KW  - Respiration Disorders -- In Old Age
KW  - Cross Sectional Studies
KW  - Questionnaires
KW  - Cardiovascular Risk Factors
KW  - Health Behavior
KW  - Regression
KW  - Chi Square Test
KW  - T-Tests
KW  - Blacks
KW  - Whites
KW  - Time Factors
KW  - Body Constitution
KW  - Sex Factors
KW  - Smoking Cessation -- In Old Age
KW  - Prospective Studies
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 2741
EP  - 2748
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 269
IS  - 21
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To investigate relationships between cigarette smoking and pulmonary function in elderly men and women.Design: Cross-sectional analysis of baseline data from a prospective, population-based study of risk factors, preclinical, and overt cardiovascular and pulmonary disease.Setting: Defined communities in Forsyth County, North Carolina; Pittsburgh, Pa; Sacramento County, California; and Washington County, Maryland.Population: A total of 5201 noninstitutionalized men and women 65 years of age and older.Main Outcome Measures: Pulmonary function; means of forced expiratory volume in 1 second (FEV1) and forced vital capacity and prevalence of low FEV1 levels.Results: Prevalence of cigarette smoking was 10% to 20% and higher in women than men and in blacks than whites. Forced vital capacity and FEV1 levels were related positively to height and white race and negatively to age and waist girth. Age- and height-adjusted FEV1 means were 23% and 18% lower in male and female current smokers, respectively, than in never smokers but not reduced in never smokers currently living with a smoker. Smokers who quit before age 40 years had FEV1 levels similar to never smokers, but FEV1 levels were lower by 7% and 14% in smokers who quit at ages 40 to 60 years and older than 60 years, respectively. Lung function was related inversely to pack-years of cigarette use. Prevalence rates of impaired lung function were highest in current smokers and lowest in never smokers. Regression coefficients for the smoking variables were smaller in persons without cardiovascular or respiratory conditions than in the total cohort.Conclusions: Cigarette smoking is associated with reduced pulmonary function in elderly men and women. However, smokers who quit, even after age 60 years, have better pulmonary function than continuing smokers.
SN  - 0098-7484
AD  - National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md 20892
AD  - Natl Heart Lung Blood Inst, Natl Inst Health, Bethesda, MD
U2  - PMID: 8492399.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107470174&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104787271
T1  - The measurement of alcohol-related accidents.
AU  - Harford, T C
Y1  - 1993/07//
N1  - Accession Number: 104787271. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Accidents
KW  - Alcohol Drinking -- Epidemiology
KW  - Alcohol Drinking
KW  - Bias (Research)
KW  - Breath Tests
KW  - Causal Attribution
KW  - Ethanol -- Blood
KW  - Ethics
KW  - Human
KW  - Wounds and Injuries -- Epidemiology
KW  - Wounds and Injuries -- Etiology
SP  - 907
EP  - 912
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 7
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This paper examines some of the major ethical and research issues associated with the measurement and recording of alcohol-related problems. Because self-reports of the history of the amount of alcohol ingested are sometimes unreliable, the assessment of the role of alcohol in casualties often relies on a variety of methods which are both diverse and interrelated. The unique measurement problems posed by the diversity of alcohol measures are reviewed and issues in selection and recording bias of alcohol's involvement in injury are discussed. A number of fundamental ethical and moral issues related to measurement are identified.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, MD 20857.
U2  - PMID: 8358262.
DO  - 10.1111/j.1360-0443.1993.tb02108.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104787271&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Nair, Padmanabhan P.
AU  - Judd, Joseph T.
AU  - Berlin, Elliott
AU  - Taylor, Philip R.
AU  - Shami, Samina
AU  - Sainz, Eduardo
AU  - Bhagavan, Hemmige N.
T1  - Dietary fish oil-induced changes in the distribution of α-tocopherol, retinol, and β-carotene in plasma, red blood cells, and platelets: modulation by vitamin E.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/07//
VL  - 58
IS  - 1
M3  - Article
SP  - 98
EP  - 102
SN  - 00029165
AB  - Healthy men (ages 24-57 y) were fed a controlled basal diet supplemented with I 5 g/d of placebo oil (P0) for 10 wk followed by 1 5 g/d offish-oil concentrate (FO)(fortified with 15 mg all-rac-tocopherol) for 10 wk without additional α-tocopherol and the last 8 wk with 200 mg α-tocopherol/d (FO + E). Compared with PO, FO raised plasma malondialdehyde: lowered α-tocopherol in plasma. red blood cells. and platelets: and raised plasma and platelet β-carotene. Supplementation with additional α-tocopherol (FO + E) not only restored tocopherol concentrations but also reversed the rise in β-carotene. The response in retinol. particularly in platelets. showed an inverse relationship to β-carotene, α-tocopherol exhibiting a modulating effect on these changes. From these observations it is postulated that platelets may be a significant extraintestinal site of retinol formation from β-carotene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Dietary supplements
KW  - Fish oils in human nutrition
KW  - Vitamin E deficiency
KW  - Retinol-binding proteins
KW  - Malondialdehyde
KW  - Blood platelets
KW  - α-tocopherol
KW  - β-carotene
KW  - fish oil
KW  - n-3 Polyunsaturated fatty acids
KW  - platelets
KW  - polyunsaturated fatty acids
KW  - red blood cells
KW  - retinol
KW  - vitamin A
KW  - vitamin E
N1  - Accession Number: 94426438; Nair, Padmanabhan P. 1,2,3,4,5; Judd, Joseph T. 1,2,3,4,5; Berlin, Elliott 1,2,3,4,5; Taylor, Philip R. 1,2,3,4,5; Shami, Samina 1,2,3,4,5; Sainz, Eduardo 1,2,3,4,5; Bhagavan, Hemmige N. 1,2,3,4,5; Affiliations: 1: Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, US Department of Agriculture, Agricultural Research Service. Beltsville, MD; 2: Department of Biochemistry and the Center for Human Nutrition, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD; 3: Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD; 4: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD; 5: Department of Clinical Nutrition. Hoffmann-La Roche Inc. Nutley, NJ; Issue Info: Jul1993, Vol. 58 Issue 1, p98; Thesaurus Term: RESEARCH; Thesaurus Term: Dietary supplements; Subject Term: Fish oils in human nutrition; Subject Term: Vitamin E deficiency; Subject Term: Retinol-binding proteins; Subject Term: Malondialdehyde; Subject Term: Blood platelets; Author-Supplied Keyword: α-tocopherol; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: fish oil; Author-Supplied Keyword: n-3 Polyunsaturated fatty acids; Author-Supplied Keyword: platelets; Author-Supplied Keyword: polyunsaturated fatty acids; Author-Supplied Keyword: red blood cells; Author-Supplied Keyword: retinol; Author-Supplied Keyword: vitamin A; Author-Supplied Keyword: vitamin E; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Seuánez, Héctor N.
AU  - Alves, Gilda
AU  - O'Brien, Stephen J.
T1  - Genetic Characterization of Parental Cell Lines and Biochemical Analysis of Somatic Cell Hybrids Between Mouse (RAG) Cells and Fibroblasts of Ateles paniscus chamek (Primates, Platyrrhini).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1993/07//
VL  - 30
IS  - 3
M3  - Article
SP  - 181
EP  - 194
SN  - 02752565
AB  - Mouse (RAG) cells, (deficient in hypoxanthine-phosphoribosyl-transferase), and Aleles paniscus chamek primary fibroblasts were used in fusion experiments to generate somatic cell hybrids. Both parental cell lines were genetically characterized by karyological and biochemical analyses with 27 isozyme systems. These procedures were useful for monitoring primate chromosomes segregation in somatic cell hybrids, for detecting chromosomes rearrangements of primate chromosomes, and for identifying individual primate chromosomes. These characterizations are necessary to distinguished between different hybrid cell lines and to generate a panel for gene mapping studies. This is achieved by selecting cell lines that segregate different sets of relatively few primate isozymes and chromosomes. Conversely, we eliminated hybrid cells lines either showing: (1) rearrangements between primate and mouse chromosomes, (2) extensive rearrangements of primate chromosomes, or (3) a large number of primate biochemical markers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL lines
KW  - SOMATIC cells
KW  - FIBROBLASTS
KW  - SPIDER monkeys
KW  - BIOCHEMISTRY
KW  - CHROMOSOMES
KW  - GENETICS
KW  - Ateles
KW  - chromosomes
KW  - hybrid cell lines
N1  - Accession Number: 12356658; Seuánez, Héctor N. 1,2 Alves, Gilda 2 O'Brien, Stephen J. 1; Affiliation:  1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland  2: Genetics Section, Instituto Nacional do Cancer, Departmento Genetica, Universidade Federal do Rio de Janeiro, Brazil; Source Info: 1993, Vol. 30 Issue 3, p181; Subject Term: CELL lines; Subject Term: SOMATIC cells; Subject Term: FIBROBLASTS; Subject Term: SPIDER monkeys; Subject Term: BIOCHEMISTRY; Subject Term: CHROMOSOMES; Subject Term: GENETICS; Author-Supplied Keyword: Ateles; Author-Supplied Keyword: chromosomes; Author-Supplied Keyword: hybrid cell lines; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bergner, Lawrence
T1  - Race, Health, and Health Services.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/07//
VL  - 83
IS  - 7
M3  - Article
SP  - 939
EP  - 941
PB  - American Public Health Association
SN  - 00900036
AB  - This section discusses various articles related to public health published within the issue.
KW  - PREFACES & forewords
KW  - PUBLIC health
N1  - Accession Number: 20672365; Bergner, Lawrence 1; Affiliation:  1: National Cancer Institute, Bethesda, Md; Source Info: Jul1993, Vol. 83 Issue 7, p939; Subject Term: PREFACES & forewords; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107354587
T1  - Etiology of nasopharyngeal carcinoma: a review.
AU  - Hildesheim A
AU  - Levine PH
Y1  - 1993/07//7/ 1/1993
N1  - Accession Number: 107354587. Language: English. Entry Date: 19960101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 7910703. 
KW  - Pharyngeal Diseases -- Etiology
KW  - Pharyngeal Diseases -- Epidemiology
KW  - Neoplasms -- Etiology
KW  - Neoplasms -- Epidemiology
KW  - Carcinoma
KW  - Sex Factors
KW  - Epstein-Barr Virus
KW  - Diet
KW  - Smoking
KW  - Occupational Exposure
KW  - Genetics
KW  - Research
KW  - Male
KW  - Female
SP  - 466
EP  - 485
JO  - Epidemiologic Reviews
JF  - Epidemiologic Reviews
JA  - EPIDEMIOL REV
VL  - 15
IS  - 2
PB  - Oxford University Press / USA
SN  - 0193-936X
AD  - Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, EPN Room 443, Bethesda, MD 20892
U2  - PMID: 8174667.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yakovlev, Gennady I.
AU  - Moiseyev, Gennady P.
AU  - Struminskaya, Nina K.
AU  - Romakhina, Elena R.
AU  - Leshchinskaya, Inna B.
AU  - Hartley, Robert W.
T1  - Increase of specificity of RNase from Bacillus amyloliquefaciens (barnase) by substitution of Glu for Ser57 using site-directed mutagenesis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1993/07//7/1/93
VL  - 215
IS  - 1
M3  - Article
SP  - 167
EP  - 170
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Bacterial ribonucleases from Bacillus amyloliquefaciens and Bacillus intermedius show the specificity towards the nature of a nucleoside at the O3′ end of the phoshodiester bond to be split in the preference order G>A[This symbol cannot be presented into ASCII text]U>C in the cleavage reactions of polynucleotides. It follows from the X-ray data that the substrate guanosine base is bound at the active site of these RNases in the same manner as for high-specificity guanylic RNases. We supposed that the difference in specificity for the two types of RNases is due to the additional hydrogen bond between the protein and a purine base in the case of bacterial guanyI-preferring RNases in contrast to the high-specificity guanylic RNases. To examine this hypothesis we prepared the Ser57→Glu mutant of B. amyloliquefaciens, in which this hydrogen bond is eliminated. Kinetic studies demonstrate that the specificity of this mutant towards guanylic substrates is 35-times greater than that of the wild-type RNases from B. amyloliquefaciens and close to that of RNases T. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RIBONUCLEASES
KW  - BACILLUS (Bacteria)
KW  - NUCLEOSIDES
KW  - NUCLEIC acids
KW  - HYDROGEN bonding
KW  - BIOCHEMISTRY
N1  - Accession Number: 12204827; Yakovlev, Gennady I. 1 Moiseyev, Gennady P. 1 Struminskaya, Nina K. 1 Romakhina, Elena R. 2 Leshchinskaya, Inna B. 2 Hartley, Robert W. 3; Affiliation:  1: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia  2: Kazan State University, Biological Department, Russia  3: Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, USA; Source Info: 7/1/93, Vol. 215 Issue 1, p167; Subject Term: RIBONUCLEASES; Subject Term: BACILLUS (Bacteria); Subject Term: NUCLEOSIDES; Subject Term: NUCLEIC acids; Subject Term: HYDROGEN bonding; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brewerton, Timothy D.
AU  - George, Mark S.
T1  - Is Migraine Related to the Eating Disorders?
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1993/07//
VL  - 14
IS  - 1
M3  - Article
SP  - 75
EP  - 79
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Migraine and the eating disorders, particularly bulimia nervosa, share some common demographics, phenomenology, psychopathology, and treatments. Bulimics also appear to be more sensitive to the induction of severe migrainous headaches than controls following challenge with the 5-HT agonist, m-chlorophenylpiperazine (rn-CPP), but not placebo or L-tryptophan. This supports a common pathophysiological relationship involving postsynaptic 5-HT dysfunction between these disorders, In order to further explore the possible relationship between eating disorders and migraine, we administered a modified version of the Diagnostic Survey of the Eating Disorders (DSED) and the Eating Disorders Inventory (EDI) to a group of female migraine patients attending the Medical University of South Carolina (MUSC) Neurology Clinic (n = 34). Of the 34 migraine patients surveyed, 88% reported dieting behavior, 59% reported binge eating, and 26% reported self-induced vomiting during their lifetimes. Compared to the responses of a group of normal female controls (n = 577), patients with migraine had elevated scores on four of the eight subscales of the EDI: Body Dissatisfaction (p ≤ .02), Perfectionism (p ≤ .01), Interpersonal Distrust (p ≤.02), and Ineffectiveness. (p ≤ .06). These findings support the hypothesis that common pathophysiological mechanisms, perhaps involving 5-HT dysregulation, may be involved in these two disorders. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MIGRAINE
KW  - EATING disorders
KW  - BULIMIA
KW  - PATIENTS
KW  - HEADACHE
KW  - COMPULSIVE eating
KW  - VOMITING
N1  - Accession Number: 11977631; Brewerton, Timothy D. 1 George, Mark S. 2; Affiliation:  1: Associate Professor, Psychiatry and Behavioral Sciences and Director, Eating Disorders Program, Institute of Psychiatry, Medical University of South Carolina.  2: Medical Staff Fellow, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD.; Source Info: Jul1993, Vol. 14 Issue 1, p75; Subject Term: MIGRAINE; Subject Term: EATING disorders; Subject Term: BULIMIA; Subject Term: PATIENTS; Subject Term: HEADACHE; Subject Term: COMPULSIVE eating; Subject Term: VOMITING; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Nicklaus, M C
AU  - Milne, G W A
T1  - Chem-X and CAMBRIDGE. Comparison of computer generated chemical structures with X-ray crystallographic data
JO  - Journal of Chemical Information & Computer Sciences
JF  - Journal of Chemical Information & Computer Sciences
Y1  - 1993/07//Jul-Aug 1993
VL  - 33
IS  - 4
M3  - Article
SP  - 639
EP  - 646
SN  - 00952338
AB  - The structures of a number of molecules as determined by X-ray crystallography have been compared with the structures for the same molecules as calculated by the 3D structure generation program, Chem-X. In the group of molecules examined, ChemModel produced structures that were essentially identical to those based upon X-ray data in 57% of the cases. The corresponding figure for the widely used alternative model builder, CONCORD, was 38%. The superior performance of ChemModel was due entirely to that program's ability to generate multiple structures covering the entire conformational space.
KW  - Chemical data
KW  - Computer programs
KW  - X-ray
N1  - Accession Number: ISTA2802823; Nicklaus, M C 1; Milne, G W A; Affiliations: 1 : National Institutes of Health, Bethesda, MD;  Source Info: Jul-Aug 1993, Vol. 33 Issue 4, p639; Note: Update Code: 2800; Author-Supplied Keyword: Chemical data; Author-Supplied Keyword: Computer programs; Author-Supplied Keyword: X-ray; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Elia, Josephine
AU  - Welsh, Patricia A.
AU  - Gullotta, Charles S.
AU  - Rapoport, Judith L.
T1  - Classroom Academic Performance: Improvement with both Methylphenidate and Dextroamphetamine in ADHD Boys.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1993/07//
VL  - 34
IS  - 5
M3  - Article
SP  - 785
EP  - 804
SN  - 00219630
AB  - Daily academic classroom performance was recorded in a day hospital school using a commonly employed reading and math series as part of an 11-week double-blind, placebo controlled, crossover comparison of dextroamphetamine (d-AMPH) and methylphenidate (MPH) in 33 hyperactive boys. Students attempted more math and reading tasks while on either active drug. The percent correct and the number of attempted problems of the reading series improved with both drugs while the percent correct for the math series occurred with d-AMPH only. No dose-response relationship was found for either stimulant. Moderate, transient adverse effects were common for both drugs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Child Psychology & Psychiatry & Allied Disciplines is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ATTENTION-deficit hyperactivity disorder
KW  - HYPERACTIVE children
KW  - STIMULANTS
KW  - DRUGS -- Physiological effect
KW  - MATHEMATICS
KW  - READING disability
KW  - academic performance
KW  - dextroamphetamine
KW  - Hyperactivity
KW  - methylphenidate
KW  - stimulants
N1  - Accession Number: 11361681; Elia, Josephine 1 Welsh, Patricia A. 2 Gullotta, Charles S. 1 Rapoport, Judith L. 1; Affiliation:  1: National Institute of Mental Health, Bethesda, MD, U S.A  2: Montgomery County Public Schools, Rockville, MD, U S A; Source Info: Jul1993, Vol. 34 Issue 5, p785; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: HYPERACTIVE children; Subject Term: STIMULANTS; Subject Term: DRUGS -- Physiological effect; Subject Term: MATHEMATICS; Subject Term: READING disability; Author-Supplied Keyword: academic performance; Author-Supplied Keyword: dextroamphetamine; Author-Supplied Keyword: Hyperactivity; Author-Supplied Keyword: methylphenidate; Author-Supplied Keyword: stimulants; Number of Pages: 20p; Document Type: Article
L3  - 10.1111/1469-7610.ep11361681
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ashery, Rebecca Sager
T1  - Nontraditional Employees: Indigenous Outreach Workers Employed as AIDS Educators for Street Addicts.
JO  - Journal of Community Psychology
JF  - Journal of Community Psychology
Y1  - 1993/07//
VL  - 21
IS  - 3
M3  - Article
SP  - 200
EP  - 209
PB  - John Wiley & Sons, Inc.
SN  - 00904392
AB  - This descriptive study examined issues in the employment of indigenous outreach workers (OWs) hired to deliver AIDS risk-reduction messages to street addicts who were not in treatment. Twenty-six projects responded to a mailed questionnaire. These projects were part of the National Institute on Drug Abuse (NIDA) funded National AIDS Demonstration research(NADR) projects. Fifty-eight percent of the OWs hired were recovering addicts with an average of just over 2 years in recovery. Out of a total of 395 OWs hired, 61% left prior to the conclusion of the 3-year project. Of those who left, 62% left employment within the first year. The study recognizes that OWs are "nontraditional" employees, and suggestions are given for further study and to increase retention. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease) education
KW  - EMPLOYEES
KW  - DRUG abuse
KW  - QUESTIONNAIRES
KW  - PERSONNEL management
KW  - NATIONAL Institute on Drug Abuse
N1  - Accession Number: 11987542; Ashery, Rebecca Sager 1; Affiliation:  1: National Institutes of Health, National Institute on Drug Abuse, Community Research Branch, Rockville, Maryland.; Source Info: Jul93, Vol. 21 Issue 3, p200; Subject Term: AIDS (Disease) education; Subject Term: EMPLOYEES; Subject Term: DRUG abuse; Subject Term: QUESTIONNAIRES; Subject Term: PERSONNEL management; Company/Entity: NATIONAL Institute on Drug Abuse; NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tsuboi, Ryoji
AU  - Sato, Chiyo
AU  - Kurita, Yoriyuki
AU  - Ron, Dina
AU  - Rubin, Jeffrey S.
AU  - Ogawa, Hideoki
T1  - Keratinocyte Growth Factor (FGF-7) Stimulates Migration and Plasminogen Activator Activity of Normal Human Deratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/07//
VL  - 101
IS  - 1
M3  - Article
SP  - 49
EP  - 53
SN  - 0022202X
AB  - Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family (and alternatively designated FGF-7), is a paracrine growth factor produced by mesenchymal cells and mitogenic specifically for epithelial cells. The potential effect of KGF on wound healing was assessed in vitro by measuring randomized migration and plasminogen activator (PA) activity of keratinocytes in response to the growth factor. Incubation of normal human keratinocytes with KGF in modified MCDB 153 medium significantly stimulated cell migration and PA activity compared with control (p <0.001 and p < 0.01, respectively). When tested in these assays on an equimolar basis, 1 nM KGF was at least as potent as transforming growth factor alpha and more active than basic FGF. None of these effects were observed when KGF was administered to fibroblasts or endothelial cells. Stimulation of keratinocyte migration by KGF was dose dependent, and a neutralizing monoclonal antibody against KGF reduced KGF-stimulated migration and cell growth. Zymographic analyses of cell extracts and conditioned medium from KGF-treated keratinocytes revealed increased PA activity, which was mainly attributable to an elevated level of urokinase-type PA. These in vitro results suggest that KGF may have an important role in stimulating reepithelialization during the process of wound repair. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - GROWTH factors
KW  - PARACRINE mechanisms
KW  - EPITHELIAL cells
KW  - WOUND healing
KW  - PLASMINOGEN activators
N1  - Accession Number: 12358892; Tsuboi, Ryoji 1 Sato, Chiyo 1 Kurita, Yoriyuki 1 Ron, Dina 2 Rubin, Jeffrey S. 3 Ogawa, Hideoki 1; Affiliation:  1: Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.  2: Biology Faculty, Technion-Israeli Institute of Technology, Haifa, Israel.  3: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul93, Vol. 101 Issue 1, p49; Subject Term: KERATINOCYTES; Subject Term: GROWTH factors; Subject Term: PARACRINE mechanisms; Subject Term: EPITHELIAL cells; Subject Term: WOUND healing; Subject Term: PLASMINOGEN activators; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12358892
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104787519
T1  - The treatment of inclusion body myositis: a retrospective review and a randomized, prospective trial of immunosuppressive therapy.
AU  - Leff, R L
AU  - Miller, F W
AU  - Hicks, J
AU  - Fraser, D D
AU  - Plotz, P H
Y1  - 1993/07//1993 Jul
N1  - Accession Number: 104787519. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Cells -- Pathology
KW  - Immunosuppression
KW  - Muscles -- Pathology
KW  - Myositis, Inclusion Body -- Drug Therapy
KW  - Adult
KW  - Aged
KW  - Autoantibodies -- Analysis
KW  - Azathioprine -- Administration and Dosage
KW  - Clinical Trials
KW  - Drug Therapy, Combination
KW  - Female
KW  - Human
KW  - Leucovorin -- Administration and Dosage
KW  - Male
KW  - Methotrexate -- Administration and Dosage
KW  - Middle Age
KW  - Myositis, Inclusion Body -- Immunology
KW  - Myositis, Inclusion Body -- Pathology
KW  - Prednisone -- Administration and Dosage
KW  - Prospective Studies
KW  - Retrospective Design
SP  - 225
EP  - 235
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 72
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - We have sought to examine the response to immunosuppressive therapeutic intervention in inclusion body myositis (IBM) in a retrospective review of prior responses to therapy and in an open, randomized crossover trial. We collected information on the response to prior therapy on 25 patients, and for prospective therapy on 11 of these patients. All met criteria for a definite idiopathic inflammatory myopathy and had biopsy-proven IBM. Clinical and laboratory results were assessed by interviews of patients and by chart review in the retrospective trial. Manual muscle strength was assessed by a single trained observer; the patients' activities of daily living were assessed by questionnaire; and serum tests of muscle-associated enzymes were measured in the prospective trial. In the retrospective review, prednisone appeared to have been of some, albeit modest, clinical benefit in 10 of 25 (40%) patients. Other therapies, primarily azathioprine and methotrexate, also appeared to have halted the progression of weakness in 8 of 35 trials (23%). In the prospective study, combination therapy of oral azathioprine and methotrexate and a biweekly infusion of high-dose intravenous methotrexate with leucovorin rescue were given for 3 to 6 months in an open, crossover design. Both the oral and the intravenous regimens were clinically effective in some patients. There was clinical improvement in 3 trials, stabilization in 11 trials, and worsening in 5 trials, out of a total of 19 completed (22 intended) trials. The presence of active inflammation at entry into the prospective therapeutic protocol, either directly observed on muscle biopsy or indirectly indicated by serum creatine kinase level, may have been associated with clinical improvement. A complete laboratory response with normalization of creatine kinase and other muscle-associated enzymes did not, however, significantly predict clinical responsiveness in the prospective trial. In this first report, to our knowledge, of a prospective trial of immunosuppressive therapy for this disease, stabilization and even slight improvement of strength and functional abilities appeared to be achieved in some patients. We believe that prednisone and other immunosuppressive therapies were of modest benefit in about half of patients with inclusion body myositis, especially those with some evidence of active inflammation. Stabilization of an otherwise inexorably deteriorating course appears, therefore, to be an attainable goal in some patients with IBM.
SN  - 0025-7974
AD  - Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
U2  - PMID: 8393509.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104787519&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1994-01544-001
AN  - 1994-01544-001
AU  - Hamer, Dean H.
AU  - Hu, Stella
AU  - Magnuson, Victoria L.
AU  - Hu, Nan
AU  - Pattatucci, Angela M. L.
T1  - A linkage between DNA markers on the X chromosome and male sexual orientation.
JF  - Science
JO  - Science
JA  - Science
Y1  - 1993/07//
VL  - 261
IS  - 5119
SP  - 321
EP  - 327
CY  - US
PB  - American Assn for the Advancement of Science
SN  - 0036-8075
N1  - Accession Number: 1994-01544-001. PMID: 8332896 Partial author list: First Author & Affiliation: Hamer, Dean H.; NIH, National Cancer Institute Lab of Biochemistry, Bethesda, MD, US. Release Date: 19940101. Correction Date: 20130225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biological Markers; Genetic Linkage; Male Homosexuality; Sex Chromosomes. Minor Descriptor: DNA; Family Members. Classification: Sexual Behavior & Sexual Orientation (2980). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 7. Issue Publication Date: Jul, 1993. 
AB  - Investigated the role of genetics in male sexual orientation by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these Ss, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were 2 gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64% of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, indicated a statistical confidence level of more than 99% that at least 1 subtype of male sexual orientation is genetically influenced. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - linkage analysis of DNA markers on X chromosome
KW  - male sexual orientation
KW  - families of male homosexuals
KW  - 1993
KW  - Biological Markers
KW  - Genetic Linkage
KW  - Male Homosexuality
KW  - Sex Chromosomes
KW  - DNA
KW  - Family Members
KW  - 1993
DO  - 10.1126/science.8332896
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1994-01544-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13538-020
AN  - 2008-13538-020
AU  - Gaffan, D.
AU  - Murray, E. A.
AU  - Fabre-Thorpe, M.
T1  - Interaction of the amygdala with the frontal lobe in reward memory.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1993/07//
VL  - 5
IS  - 7
SP  - 968
EP  - 975
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Gaffan, D., Department of Experimental Psychology, Oxford University, South Parks Road, Oxford, United Kingdom, OX1 3UD
N1  - Accession Number: 2008-13538-020. PMID: 8281307 Partial author list: First Author & Affiliation: Gaffan, D.; Department of Experimental Psychology, Oxford University, Oxford, United Kingdom. Other Publishers: Blackwell Publishing. Release Date: 20090316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amygdala; Frontal Lobe; Memory; Rewards; Visual Stimulation. Minor Descriptor: Animal Learning; Monkeys. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1993. 
AB  - Five cynomolgus monkeys (Macaca fascicularis) were assessed for their ability to associate visual stimuli with food reward. They learned a series of new two-choice visual discriminations between coloured patterns displayed on a touch-sensitive monitor screen; the feedback for correct choice was delivery of food. Normal learning in this task is known to be dependent on the amygdala. The monkeys received brain lesions which were designed to disconnect the amygdala from interaction with other brain structures thought to be involved in this memory task. All the monkeys received an amygdalectomy in one hemisphere and lesions in the other hemisphere of some of the projection targets of the amygdala, namely the ventral striatum, the mediodorsal thalamus and the ventromedial prefrontal cortex. The rate of learning new problems was assessed before and after each operation. Disconnection of the amygdala from the ventral striatum was without effect on learning rate. An earlier study had shown that disconnection of the amygdala from either the mediodorsal thalamus or the ventromedial prefrontal cortex produced only a mild impairment, significantly less severe than that produced by bilateral lesions of any of these three structures. The present results show, however, that disconnection of the amygdala from both the mediodorsal thalamus and the ventromedial prefrontal cortex in the same animal, by crossed unilateral lesions of the amygdala in one hemisphere and of both the mediodorsal thalamus and the ventromedial prefrontal cortex in the other hemisphere, produces an impairment as severe as that which follows bilateral lesions of any of these three structures. These results show that, in stimulus-reward associative memory, the role of the amygdala is entirely dependent on its interaction with the frontal lobe, either by direct projections or by indirect subcortical pathways including the mediodorsal nucleus of the thalamus; and that there are at least two partially independent pathways by which the amygdala can influence the frontal lobe. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - amygdala
KW  - frontal lobe
KW  - reward memory
KW  - monkeys
KW  - visual stimuli
KW  - 1993
KW  - Amygdala
KW  - Frontal Lobe
KW  - Memory
KW  - Rewards
KW  - Visual Stimulation
KW  - Animal Learning
KW  - Monkeys
KW  - 1993
U1  - Sponsor: Medical Research Council, United Kingdom. Recipients: No recipient indicated
U1  - Sponsor: North Atlantic Treaty Organization. Grant: 0184/87. Recipients: No recipient indicated
U1  - Sponsor: Fondation pour la Recherche Médicale. Recipients: No recipient indicated
U1  - Sponsor: Fondation Simone et Cino del Duca. Recipients: No recipient indicated
DO  - 10.1111/j.1460-9568.1993.tb00948.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13538-020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Yuspa, Stuart H.
AU  - Wang, Qizhi
AU  - Weinberg, Wendy C.
AU  - Goodman, Linda
AU  - Ledbetter, Steven
AU  - Dooley, Tom
AU  - Lichti, Ulrike
T1  - Regulation of Hair Follicle Development: An <em>In Vitro</em> Model for Hair Follicle Invasion of Dermis and Associated Connective Tissue Remodeling.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/07/15/Jul93 Supplement
VL  - 101
M3  - Article
SP  - 27S
EP  - 32S
SN  - 0022202X
AB  - During embryonic development presumptive hair follicle cells of epithelial and mesenchymal origin are determined in defined body locations. This is followed by rapid proliferation of epithelial cells and associated penetration into the dermis in response to as yet undetermined signals. A collagen matrix culture system, which maintains the three-dimensional relationships of hair follicle cells to each other, was developed to study the regulation of the enlargement of immature hair follicles and the accompanying remodeling of the dermis. In studies with a heterogeneous dermis-derived preparation of murine hair follicles, ranging in size from the earliest down-growing budding cell mass to hair-forming follicles, we had previously shown that cell proliferation was stimulated by cholera toxin and epidermal growth factor, but only the epidermal growth factor-stimulated proliferation was accompanied by digestion of the collagen matrix due to release of collagenolytic enzymes. Further studies revealed that transforming growth factor-α also stimulated hair follicle cell proliferation and collagenase release. However, although transforming growth factor-β inhibited the transforming growth factor-α-stimulated proliferation, it enhanced the release and activation of collagenases and other gelatin-degrading enzymes detectable by gelatin zymography. Stimulation of collagenolytic activity depended on the three-dimensional hair follicle structure and did not occur in monolayer cultures of hair follicle cells. Comparison of hair follicle buds with more developed dermis-derived hair follicles, plated at the same cell density (based on DNA content), suggested that a greater fraction of cells in the bud-stage follicle responded to the growth factors by release of collagenases. Possibly only the cells in the advancing portion of growing hair follicles that are closest to the dermal papilla cell cluster produce the collagenases in response to growth factors. To examine the participation of dermal papilla cells in collagenase release and activation, several immortalized rat whisker dermal papilla cell liners were co-cultured with mouse hair follicle buds. Co-culture resulted in a marked enlargement of follicles as well as activation of the 92-kDa type IV collagenase, produced by hair follicle buds, that correlated with ability of the dermal papilla cells to stimulate hair formation in grafts of hair follicle buds on nude mice. Dermal papilla cells cultured alone produced the 72-kDa type IV collagenase, which was also activated during co-culture with hair follicle buds. Thus, two activities, both relevant for hair follicle development, namely, cell proliferation and release and activation of collagenases, have been stimulated in immature hair follicle buds by either growth-factor supplementation or interaction with dermal papilla cells. The collagen matrix culture system allows investigation of the mechanism by which these activities are controlled under defined <em>in vitro</em> conditions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR follicles
KW  - EPITHELIUM
KW  - COLLAGEN
KW  - GELATIN
KW  - PEPTIDES
KW  - CELL proliferation
KW  - GROWTH factors
N1  - Accession Number: 12362567; Yuspa, Stuart H. 1 Wang, Qizhi 2 Weinberg, Wendy C. 1 Goodman, Linda 3 Ledbetter, Steven 3 Dooley, Tom 4 Lichti, Ulrike 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  3: Cancer Research, The Upjohn Company, Kalamazoo, Michigan.  4: Southwest Foundation for Biomedical Research, San Antonio, Texas, U.S.A.; Source Info: Jul93 Supplement, Vol. 101, p27S; Subject Term: HAIR follicles; Subject Term: EPITHELIUM; Subject Term: COLLAGEN; Subject Term: GELATIN; Subject Term: PEPTIDES; Subject Term: CELL proliferation; Subject Term: GROWTH factors; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12362567
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12362567&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - O'Keefe, Edward J.
AU  - Hamilton, Elizabeth H.
AU  - Lee, Seung-Chul
AU  - Steinert, Peter
T1  - Trichohyalin: A Structural Protein of Hair, Tongue, Nail, and Epidermis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/07/15/Jul93 Supplement
VL  - 101
M3  - Article
SP  - 65S
EP  - 71S
SN  - 0022202X
AB  - In the course of studies of desmosomes, we found trichohyalin, a 200-kDa protein of the inner root sheath and medulla, in a citric acid-insoluble fraction ("desmosome preparation") from tongue epithelium. Pig tongue epithelium yielded milligram quantities of pure trichohyalin from about 100 g of keratomed epithelium. The protein has an extended shape as determined by gel filtration, ultracentrifugation, and electron microscopy, with a rod domain and a globular domain at one end and overall dimensions of about 85 nm. Crosslinking studies suggest that the protein may be dimeric in solution. The protein is a doublet in some animals but apparently is a single polypeptide of 220 kDa in humans. Irnmunofluorescence studies showed that it is a major protein of the filiform papillae of the tongue of mammals and is present in isolated cells of the stratum granulosum of some regions of epidermis in a subset of cells containing filaggrin and in the nail matrix. Similarly, in filiform papillae some cells contain granules that stain for both trichohyalin and filaggrin. Immunoblotting confirmed that trichohyalin is present in tongue and epidermis. Polymerase chain reaction with human genomic DNA using oligonucleotide primers based on sheep trichohyalin resulted in synthesis of multiple DNAs, from which a 504-hp fragment was subcloned and sequenced and found to resemble closely the carboxyl terminus of sheep trichohyalin. Studies with antibody to the carboxyl-terminal 14 amino acids of the human sequence show that, whereas the carboxyl-terminal epitope is present only in the stratum granulosum, in epidermis epitopes detected by a monoclonal antibody are demonstrated in both the stratum granulosum and stratum corneum, suggesting that the carboxyl terminus is cleaved in the stratum corneum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DESMOSOMES
KW  - EPITHELIAL cells
KW  - CELL adhesion molecules
KW  - GEL permeation chromatography
KW  - ULTRACENTRIFUGATION
KW  - DNA
KW  - OLIGONUCLEOTIDES
KW  - AMINO acids
N1  - Accession Number: 12362866; O'Keefe, Edward J. 1 Hamilton, Elizabeth H. 1 Lee, Seung-Chul 2 Steinert, Peter 2; Affiliation:  1: Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina.  2: Skin Biology Branch, National Institute of Arthritis Metabolic and Skin Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul93 Supplement, Vol. 101, p65S; Subject Term: DESMOSOMES; Subject Term: EPITHELIAL cells; Subject Term: CELL adhesion molecules; Subject Term: GEL permeation chromatography; Subject Term: ULTRACENTRIFUGATION; Subject Term: DNA; Subject Term: OLIGONUCLEOTIDES; Subject Term: AMINO acids; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12362866
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12362866&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lichti, Ulrike
AU  - Weinberg, Wendy C.
AU  - Goodman, Linda
AU  - Ledbetter, Steve
AU  - Dooley, Tom
AU  - Morgan, Dave
AU  - Yuspa, Stuart H.
T1  - <em>In Vivo</em> Regulation of Murine Hair Growth: Insights from Grafting Defined Cell Populations onto Nude Mice.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/07/15/Jul93 Supplement
VL  - 101
M3  - Article
SP  - 124S
EP  - 129S
SN  - 0022202X
AB  - The nude mouse graft model for testing the hair-forming ability of selected cell populations has considerable potential for providing insights into factors that are important for hair follicle development and proper hair formation. We have developed a minimal component system consisting of immature hair follicle buds from newborn pigmented C57BL/6 mice and adenovirus E1A-immortalized rat vibrissa dermal papilla cells. Hair follicle buds contribute to formation of hairless skin when grafted alone or with Swiss 3T3 cells, but produce densely haired skin when grafted with a fresh dermal cell preparation. The fresh dermal cell preparation represents the single cell fraction after hair follicles have been removed from a collagenase digest of newborn mouse dermis. It provides dermal papilla cells, fibroblasts, and possibly other important growth factor-producing cell types. Rat vibrissa dermal papilla cells supported dense hair growth at early passage in culture but progressively lost this potential during repeated passage in culture. Of 19 E1A-immortalized, clonally derived rat vibrissa dermal papilla cell lines, the four most positive clones supported hair growth to the extent of approximately 200 to 300 hairs per 1 - 2 cm² graft area. The remaining clones were moderately positive (five clones), weakly positive (three clones), or negative (seven clones). Swiss 3T3 cells prevented contraction of the graft area but did not appear to affect the number of hairs in the graft site produced by dermal papilla cells plus hair follicle buds alone. The relatively low hair density (estimated 1-5% of normal) resulting from grafts of hair follicle budds with the most positive of the immortalized dermal papilla cell clones compared to fresh dermal cells suggests that optimal reconstitution of hair growth requires some function of dermal papilla cells partially lost during the immortalization process and possibly the contribution of other cell types present in the fresh dermal cell preparation, which is not supplied by the Swiss 3T3 cells. The current graft system, comprising hair follicle buds and immortalized dermal papilla cell clones, provides an assay for positive or negative influences on hair growth exerted by added selected cell types, growth factors, or other substances. Characterization of the phenotype of the dermal papilla cell lines, which differ in their ability to support hair growth when grafted with hair follicle buds, may provide insight into specific dermal papilla cell properties important for their function in this system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN-grafting
KW  - HAIR growth stimulants
KW  - DERMATOLOGIC agents
KW  - CELL proliferation
KW  - HAIR follicles
KW  - CELLULAR growth
KW  - PEPTIDES
N1  - Accession Number: 12363165; Lichti, Ulrike 1 Weinberg, Wendy C. 1 Goodman, Linda 2 Ledbetter, Steve 2 Dooley, Tom 3 Morgan, Dave 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, Maryland.  2: Cancer Research, Upjohn Company, Kalamazoo, Michigan.  3: Southwest Foundation for Biomedical Research, San Antonio, Texas, U.S.A.; Source Info: Jul93 Supplement, Vol. 101, p124S; Subject Term: SKIN-grafting; Subject Term: HAIR growth stimulants; Subject Term: DERMATOLOGIC agents; Subject Term: CELL proliferation; Subject Term: HAIR follicles; Subject Term: CELLULAR growth; Subject Term: PEPTIDES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12363165
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12363165&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Russo, Thomas A.
AU  - Guenther, Jane E.
AU  - Wenderoth, Suzanne
AU  - Frank, Michael M.
T1  - Generation of isogenic K54 capsule-deficient Escherichia coli strains through TnphoA-mediated gene disruption.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/07/15/
VL  - 9
IS  - 2
M3  - Article
SP  - 357
EP  - 364
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Transposon mutagenesis, using IS<em>50</em>L<em>phoA</em>(Tn-<em>phoA</em>), was performed in a K54/O4/H5 blood isolate of <em>Escherichia coli</em> (CP9), to generate a library of random mutants. Five hundred and twenty-six independent CP9 Tn<em>phoA</em> mutants were isolated with active gene fusions to alkaline phosphatass. From this mutant library, eight capsule-deficient strains were detected and were found to have a single copy of Tn<em>phoA</em>. Sixteen additional capsule deficient mutants with Tn<em>phoA</em> inserts were subsequently obtained that did not possess active PhoA fusions. In conjunction with the initial eight capsule-deficient isolates we have defined genes on three different <em>Xba</em>l fragments as being involved in capsule production. Generalized transduction with the bacteriophage T4 established that these insertions were responsible for the loss of capsule and that they are linked. These capsule-deficient strains can be used to assess the pathogenic role of the K54 capsular polysaccharide. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Polysaccharides
KW  - Transposons
KW  - Mutagenesis
KW  - Genes
KW  - Translocation (Genetics)
N1  - Accession Number: 16580953; Russo, Thomas A. 1; Guenther, Jane E. 1; Wenderoth, Suzanne 1; Frank, Michael M. 1,2; Affiliations: 1: Bacterial Pathogenesis Unit, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA; Issue Info: Jul1993, Vol. 9 Issue 2, p357; Thesaurus Term: Escherichia coli; Thesaurus Term: Polysaccharides; Subject Term: Transposons; Subject Term: Mutagenesis; Subject Term: Genes; Subject Term: Translocation (Genetics); Number of Pages: 8p; Illustrations: 5 Diagrams, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Flegal, Katherine M.
AU  - Graubard, Barry I.
AU  - Launer, Lenore J.
AU  - Kestler, Edgar
AU  - Villar, Jose
T1  - Modeling maternal weight and height in studies of pregnancy outcome among Hispanic women.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/08//
VL  - 58
IS  - 2
M3  - Article
SP  - 145
EP  - 151
SN  - 00029165
AB  - The objective of this study was to evaluate methods of using maternal weight and height in studies of pregnancy outcome for Hispanic women. Reference anthropometric data came from 1166 Mexican-American women in the Hispanic Health and Nutrition Examination Survey (HHANES). Prospective data on maternal anthropometry and infant birth weight came from 1362 Hispanic women in the Kaiser-Permanente Contraceptive Drug Study and 12 786 women in the Guatemalan Cooperative Perinatal Study. Five methods of standardizing weight for height were evaluated, including power-type indexes and weights relative to HHANES reference data. In linear- and logistic-regression analyses, these methods were practically interchangeable, with no evident advantage of Hispanic reference data. However, if weight was not height-standardized the effect of height was underestimated; if height was omitted and weight was not height-standardized the effects of weight were exaggerated. Therefore, analyses of pregnancy outcome should include both height and height-standardized weight. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - Pregnant women -- Weight gain
KW  - Hispanic Americans -- Anthropometry
KW  - Birth weight
KW  - Pregnant women
KW  - Logistic regression analysis
KW  - Body mass index
KW  - Anthropometry
KW  - birth weight
KW  - body height
KW  - body mass index
KW  - body weight
KW  - Central America
KW  - epidemiologic methods
KW  - Guatemala
KW  - Hispanic Americans
KW  - Mexican Americans
KW  - pregnancy outcome
N1  - Accession Number: 94403211; Flegal, Katherine M. 1,2,3; Graubard, Barry I. 1,2,3; Launer, Lenore J.; Kestler, Edgar 1,2,3; Villar, Jose 1,2,3; Affiliations: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD; 2: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; 3: Perinatal Research Program, Gynecology and Obstetrics Hospital, Guatemalan Social Security Institute, Guatemala City, Guatemala; Issue Info: Aug1993, Vol. 58 Issue 2, p145; Thesaurus Term: HEALTH; Subject Term: Pregnant women -- Weight gain; Subject Term: Hispanic Americans -- Anthropometry; Subject Term: Birth weight; Subject Term: Pregnant women; Subject Term: Logistic regression analysis; Subject Term: Body mass index; Author-Supplied Keyword: Anthropometry; Author-Supplied Keyword: birth weight; Author-Supplied Keyword: body height; Author-Supplied Keyword: body mass index; Author-Supplied Keyword: body weight; Author-Supplied Keyword: Central America; Author-Supplied Keyword: epidemiologic methods; Author-Supplied Keyword: Guatemala; Author-Supplied Keyword: Hispanic Americans; Author-Supplied Keyword: Mexican Americans; Author-Supplied Keyword: pregnancy outcome; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Gillitzer, Reinhard
AU  - Wolff, Klaus
AU  - Tong, Dan
AU  - Müller, Christoph
AU  - Yoshimura, Teizo
AU  - Hartmann, Albert A.
AU  - Stingl, Georg
AU  - Berger, Rudolf
T1  - MCP-1 mRNA Expression in Basal Keratinocytes of Psoriatic Lesions.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/08//
VL  - 101
IS  - 2
M3  - Article
SP  - 127
EP  - 131
SN  - 0022202X
AB  - In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal compartment. By immunohistologic analysis, these dermal macrophages were mainly encountered in the papillary dermis and arranged along the rete ridges in close proximity to proliferating keratinocytes. Monocyte chemoattractant protein (MCP-1) anti-sense RNA probes yielded abundant signals over the proliferating basal keratinocytes of the tips of the rete ridges, and, to a lesser extent, in cells in the papillae. Thus, the strongest MCP-1 message in psoriatic lesions is found above the dermal-epidermal junction and this may explain the characteristic sub-basal distribution of dermal macrophages. These results suggest that MCP-1 is important in regulating the interaction between proliferating keratinocytes and dermal macrophages in psoriasis pathogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSORIASIS
KW  - MESSENGER RNA
KW  - KERATINOCYTES
KW  - MONOCYTES
KW  - SKIN diseases
KW  - CELL proliferation
KW  - NEUTROPHILS
KW  - <em>in situ</em> hybridization
KW  - monocyte-macrophage chemotaxis
N1  - Accession Number: 12363613; Gillitzer, Reinhard 1 Wolff, Klaus 2 Tong, Dan 2 Müller, Christoph 3 Yoshimura, Teizo 4 Hartmann, Albert A. 1 Stingl, Georg 2 Berger, Rudolf 2; Affiliation:  1: Department of Dermatology, University of Würzburg Medical School, Würzburg, Germany.  2: Department of Dermatology I, University of Vienna Medical School, Vienna, Austria.  3: Department of Pathology, University of Bern Medical School, Bern, Switzerland.  4: National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland, U.S.A.; Source Info: Aug93, Vol. 101 Issue 2, p127; Subject Term: PSORIASIS; Subject Term: MESSENGER RNA; Subject Term: KERATINOCYTES; Subject Term: MONOCYTES; Subject Term: SKIN diseases; Subject Term: CELL proliferation; Subject Term: NEUTROPHILS; Author-Supplied Keyword: <em>in situ</em> hybridization; Author-Supplied Keyword: monocyte-macrophage chemotaxis; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12363613
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Elgart, George W.
AU  - Stanley, John R.
T1  - Cloning of the 5' mRNA for the 230-kD Bullous Pemphigoid Antigen by Rapid Amplification of cDNA Ends.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/08//
VL  - 101
IS  - 2
M3  - Article
SP  - 244
EP  - 246
SN  - 0022202X
AB  - The 230-kD bullous pemphigoid antigen (BPAG1), defined by autoantibodies in patient sera, is a hemidesmosomal plaque protein in the same gene family as the intracellular proteins desmoplakin I/II and plectin. We had previously isolated, from a λgt11 library, overlapping cDNA clones with 6921 bp of mRNA sequence for BPAG1. The coding sequence encoded by these clones included the 3' stop codon but not the 5' coding and non-coding region of the mRNA. To obtain these sequences we used the polymerase chain reaction (PCR) method called rapid amplification of cDNA ends (RACE). The PCR products were cloned into plasmids and sequenced. With five PCR primers we were able to obtain overlapping clones containing the 5' region of the mRNA. An upstream stop codon in frame with the rest of the coding sequence demonstrates that the full 5' coding sequence is obtained. Four different PCR products from two separate reactions had the same 5' end, suggesting that this 5' end is near, or at, the transcription start site. No alternatively spliced clones were found and no transmembrane site was predicted, confirming that BPAG1 is an intracellular hemin-desmosomal plaque protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MESSENGER RNA
KW  - CLONING
KW  - ANTIGENS
KW  - GENETIC engineering
KW  - AUTOANTIBODIES
KW  - HEMIDESMOSOMES
KW  - adhesion.
KW  - desmoplakin
KW  - hemidesmosome
N1  - Accession Number: 12365083; Elgart, George W. 1 Stanley, John R. 1; Affiliation:  1: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug93, Vol. 101 Issue 2, p244; Subject Term: MESSENGER RNA; Subject Term: CLONING; Subject Term: ANTIGENS; Subject Term: GENETIC engineering; Subject Term: AUTOANTIBODIES; Subject Term: HEMIDESMOSOMES; Author-Supplied Keyword: adhesion.; Author-Supplied Keyword: desmoplakin; Author-Supplied Keyword: hemidesmosome; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12365083
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kocsis, E.
AU  - Trus, B. L.
AU  - Steven, A. C.
AU  - Smith, P. R.
AU  - Hannah, J. H.
AU  - Brennan, M. J.
AU  - Kessel, M.
T1  - Orientation of porin channels in the outer membrane of Bordetella pertussis.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/08//
VL  - 9
IS  - 3
M3  - Article
SP  - 469
EP  - 476
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - We have examined the surface topography and channel connectivity of a naturally crystalline porin that is known to be functional, and whose structure has not been perturbed by detergent extraction. A three-dimensional density map, calculated from two independent tilt series of negatively stained cell envelopes, reveals three separate channels per trimer on one side (the 'smooth' side), and a single common opening at the other ('rough') side. This arrangement is consistent with the molecular structures recently determined at high resolution by X-ray crystallography for three other porins after detergent solubilization, and implies that the <em>Bordetella pertussis</em> porin may have the same kind of folding. Surface relief maps calculated from electron micrographs of cell envelopes contrasted by unidirectional shadowing clearly show that the side with single opening (i.e. the rough side) represents the external surface. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cell membranes
KW  - Bordetella pertussis
KW  - Molecular structure
KW  - Protein folding
KW  - Cells
N1  - Accession Number: 16579392; Kocsis, E. 1; Trus, B. L. 1,2; Steven, A. C. 1; Smith, P. R. 3; Hannah, J. H. 4; Brennan, M. J. 4; Kessel, M. 5,6; Affiliations: 1: Laboratory of Structural Biology, National institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA; 2: Computer Systems Laboratory, Division of Computer Research and Technology, National institutes of Health, Bethesda, Maryland 20892, USA; 3: Department of Cell Biology, New York University Medical School New York, New York 10016, USA; 4: Division of Bacterial Products, Food and Drug Administration, Bethesda, Maryland 20892, USA; 5: Department of Membrane and Ultrastructure Research, Hebrew University-Hadassah Medical School, Jerusalem 91-010, Israel; 6: Department of Microbiology, University of Maryland, College Park, Maryland 20742, USA; Issue Info: Aug1993, Vol. 9 Issue 3, p469; Thesaurus Term: Cell membranes; Subject Term: Bordetella pertussis; Subject Term: Molecular structure; Subject Term: Protein folding; Subject Term: Cells; Number of Pages: 8p; Illustrations: 5 Black and White Photographs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-34603-002
AN  - 2015-34603-002
AU  - Ffrench-Mullen, Jarlath M. H.
AU  - Barker, Jeffery L.
AU  - Rogawski, Michael A.
T1  - Calcium current block by (-)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: Comparison with effects on GABA-activated CI- current.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1993/08//
VL  - 13
IS  - 8
SP  - 3211
EP  - 3221
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ffrench-Mullen, Jarlath M. H., Department of Pharmacology, Zeneca Pharmaceuticals Group, Zeneca Inc., Wilmington, DE, US, 19897-2500
N1  - Accession Number: 2015-34603-002. PMID: 8101867 Partial author list: First Author & Affiliation: Ffrench-Mullen, Jarlath M. H.; Department of Pharmacology, Zeneca Pharmaceuticals Group, Zeneca Inc., Wilmington, DE, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gamma Aminobutyric Acid; Hippocampus; Neurons; Calcium Channel. Minor Descriptor: Guinea Pigs. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Aug, 1993. Publication History: Accepted Date: Feb 16, 1993; Revised Date: Feb 10, 1993. Copyright Statement: Society for Neuroscience. 1993. 
AB  - Block of a voltage-activated Ca2+ channel current by phenobarbital (PHB), 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (CHEB), and the optical R(−)- and S(+)-enantiomers of pentobarbital (PB) was examined in freshly dissociated adult guinea pig hippocampal CA1 neurons; the effects of the barbiturates on GABA-activated Cl− current were also characterized in the same preparation. (−)-PB, PHB, and CHEB produced a reversible, concentration-dependent block of the peak Ca2+ channel current (3 mM Ba2+ as the charge carrier) evoked by depolarization from −80 to −10 mV (IC₅₀ values, 3.5, 72, and 118 μM, respectively). In contrast, (+)-PB was nearly inactive at concentrations up to 1 mM. The inhibitory action of PHB was decreased at acid pH, indicating that the dissociated (anionic) form of the molecule is the active species. Block by (−)-PB was voltage dependent with the fractional block increasing at positive membrane potentials; calculations according to the method of Woodhull indicated that the (−)- PB blocking site senses ∼40% of the transmembrane electric field. The time course and voltage dependence of activation of the Ca2+ channel current were unaffected by (−)-PB, PHB, and CHEB. The rate of inactivation was enhanced by (−)-PB and CHEB, with the major effect being acceleration of the slow phase of the biexponential decay of the current. GABA-activated Cl− current was potently enhanced by (−)-PB and PHB (EC50 values, 3.4 and 12 μM), whereas (+)-PB was only weakly active. At concentrations of (−)-PB > 100 μM and PHB > 200–300 μM, Cl− current responses were activated even in the absence of GABA. These results demonstrate that in CA1 hippocampal neurons, PB causes a stereoselective block of a voltage-activated Ca2+ current; PHB is also effective, but at higher concentrations. For (−)-PB, the effect on Ca2+ channel current occurred at similar concentrations as potentiation of GABA responses. In contrast, PHB was more potent as a GABA enhancer than as blocker of Ca2+ current, but the maximal potentiation of GABA responses was 40% of that obtained with (−)-PB. Consequently, the anticonvulsant action of PHB at clinically relevant concentrations may relate to modest enhancement of GABA responses and partial blockade of Ca2+ current, whereas the sedative effects that occur at higher concentrations could reflect stronger Ca2+ current blockade. The powerful sedative-hypnotic action of (−)-PB may reflect greater maximal enhancement of GABA responses in conjunction with strong inhibition of Ca2+ current. The convulsant action of CHEB is unlikely to be related to its effects on the Ca2+ current. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - calcium channel
KW  - GABA receptor
KW  - (-)-pentobarbital
KW  - (+)-pentobarbital
KW  - phenobarbital
KW  - CHEB [S-(2-cyclohexylideneethyl)- S-ethyl barbituric acid]
KW  - CA 1 hippocampal neuron
KW  - voltage-clamp recording
KW  - 1993
KW  - Gamma Aminobutyric Acid
KW  - Hippocampus
KW  - Neurons
KW  - Calcium Channel
KW  - Guinea Pigs
KW  - 1993
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Brunati, Anna Maria
AU  - James, Peter
AU  - Donella-Deana, Arianna
AU  - Matoskova, Brona
AU  - Robbins, Keith C.
AU  - Pinna, Lorenzo A.
T1  - Isolation and identification of two proto-oncogene products related to c-fgr and fyn in a tyrosine-protein-kinase fraction of rat spleen.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1993/08/15/
VL  - 216
IS  - 1
M3  - Article
SP  - 323
EP  - 327
PB  - Wiley-Blackwell
SN  - 00142956
AB  - TPK-III, a tyrosine-protein-kinase fraction previously isolated from rat spleen [Brunati, A. M. & Pinna, L.A. (1988) Eur. J. Biochem. 172, 451–457] has been further purified and resolved by Mono-Q FPLC into two homogeneous compounds, Q1 and Q2, with molecular mass approximately 52 kDa, exhibiting high specific activities for phosphate incorporation into the phosphoacceptor substrate poly(Glu80Tyr20) (1194 nmol · min-1 · mg1 and 579 nmol · min-1. mg-1 respectively). Both Q1 and Q2 appear to be scr-related enzymes since they are readily recognised by anti-SEEP serum raised against the highly conserved segment at positions 330–345 of p60c-scr. Q1, but not Q2, interacts with a specific antibody raised against the N-terminal segment of p55c-fgr. Microsequence analysis of tryptic fragments generated from Q1 revealed five peptides which exactly overlap the expected segments of p55c-fgr. Two of these peptides were not entirely conserved in any of the other src-related tyrosine protein kinases. A sixth fragment is very similar, albeit not identical, to the C-terminus of p55c-fgr. Microsequence analysis of two tryptic fragments from the other TPK-III fraction, Q2, provided the sequences FQILNSSE and LTTQETGYIPSNY, which are identical to two segments of fyn not entirely conserved in any of the other src-related tyrosine protein kinases. These results provide evidence that the spleen tyrosine-protein-kinase fraction, conventionally designated TPK-III, is composed of products from two proto-oncogenes, one of which corresponds to fyn, while the other is either identical or very closely related to c-fgr. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN-tyrosine kinase
KW  - SPLEEN
KW  - ENZYMES
KW  - SERUM
KW  - ONCOGENES
KW  - PHOSPHORYLATION
N1  - Accession Number: 12208986; Brunati, Anna Maria 1 James, Peter 2 Donella-Deana, Arianna 1 Matoskova, Brona 3 Robbins, Keith C. 3 Pinna, Lorenzo A. 1; Affiliation:  1: Dipartimento di Chimica Biologica and Centro per lo Studio della Fisiologia Mitocondriale del Consiglio Nazionale delle Ricerche, Università di Padova, Italy  2: Biochemie III, ETH Zentrum, Zürich, Switzerland  3: Laboratory of Cellular Development and Oncology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA; Source Info: 8/15/93, Vol. 216 Issue 1, p323; Subject Term: PROTEIN-tyrosine kinase; Subject Term: SPLEEN; Subject Term: ENZYMES; Subject Term: SERUM; Subject Term: ONCOGENES; Subject Term: PHOSPHORYLATION; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Miyasaka, Hitoshi
AU  - Choudhury, Barun K.
AU  - Hou, Esther W.
AU  - Li, Steven S.-L.
T1  - Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1993/08/15/
VL  - 216
IS  - 1
M3  - Article
SP  - 343
EP  - 352
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Mouse and human cDNA encoding AES (amino-terminal enhancer of split) and ESG (enhancer of split groucho) proteins with strong similarity to Drosophila enhancer of split groucho protein were isolated and sequenced. Mouse AES-1 and AES-2 proteins, probably resulting from alternative splicing, contain 202 and 196 amino acids, respectively, while mouse ESG protein consists of 771 amino acids. The amino acid sequences of mouse and human AES proteins were found to exhibit approximately 50% identity to the amino-terminal region of Drosophila groucho, mouse ESG and human transducin-like enhancer of split (TLE) proteins. Mouse AES transcripts of 1.5 kb and 1.2 kb were abundantly expressed in muscle, heart and brain. Human AES transcripts of 1.6 kb and 1.4 kb were predominantly present in muscle, heart and placenta. Mouse ESG (homolog of human TLE 3) transcripts of 3.3 kb and 4.0 kb were found only in testis, while human TLE 1 transcripts of 4.5 kb was more abundant in muscle and placenta compared to heart, brain, lung, liver, kidney and pancreas. Human AES, TLE 1 and TLE 3 genes were mapped to chromosomes 19, 9 and 15, respectively, using human and Chinese hamster hybrid cell lines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ATOMIC emission spectroscopy
KW  - AMINO acids
KW  - MEDICAL transcription
KW  - DROSOPHILA
KW  - CHROMOSOMES
KW  - CELL lines
N1  - Accession Number: 12208992; Miyasaka, Hitoshi 1 Choudhury, Barun K. 1 Hou, Esther W. 1 Li, Steven S.-L. 1; Affiliation:  1: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA; Source Info: 8/15/93, Vol. 216 Issue 1, p343; Subject Term: ATOMIC emission spectroscopy; Subject Term: AMINO acids; Subject Term: MEDICAL transcription; Subject Term: DROSOPHILA; Subject Term: CHROMOSOMES; Subject Term: CELL lines; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schmitz, John
AU  - DeJong, Judith
AU  - Roy, Alec
AU  - Garnett, Debra
AU  - Moore, Veronica
AU  - Lamparski, Danuta
AU  - Waxman, Robyn
AU  - Linnoila, Markku
T1  - Substance Abuse among Subjects Screened Out from an Alcoholism Research Program.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1993/09//
VL  - 19
IS  - 3
M3  - Article
SP  - 359
EP  - 368
SN  - 00952990
AB  - Three hundred and eight subjects were screened over the phone for admission to an inpatient alcohol treatment research unit. Using a structured interview, the prospective patients were asked questions regarding demographics, drinking history, previous treatments, physical health, family history, and a detailed history of past and present substance use. Drug use was studied as regular use versus no use or brief experimental use of five drug categories: cannabinoids, stimulants, sedatives, opiates, and hallucinogens. Fifty-one percent of the men and 48% of the women reported regular use of one or more of the drugs in addition to alcohol. For women, the amount of alcohol intake was positively correlated with use of stimulants (r = .32, p = .00l), cannabinoids (r = .24,p = .019), sedatives (r = .30,p = .003), and hallucinogens (r = .30, p = .003). For men, correlations between the amount of alcohol intake and drug use were weaker but significant for stimulants (r = .21, p = .002), opiates (r = .15, p = .028), and hallucinogens (r = .15,p = .029). Women with alcoholic mothers displayed higher alcohol intake than women with nonalcoholic mothers {p = .02) and also showed more frequent use of most drugs. Although men with alcoholic fathers also showed greater alcohol intake compared to men with nonalcoholic fathers, the two groups did not differ in drug use. Younger subjects of both sexes were more likely to use cannabinoids, stimulants, opiates, and hallucinogens. Alcohol and sedative use was relatively constant across all age groups. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOLISM
KW  - SUBSTANCE abuse
KW  - DRINKING of alcoholic beverages
KW  - STIMULANTS
KW  - MECLOFENOXATE
KW  - UNITED States
N1  - Accession Number: 9409010047; Schmitz, John 1 DeJong, Judith 1 Roy, Alec 1 Garnett, Debra 1 Moore, Veronica 1 Lamparski, Danuta 1 Waxman, Robyn 1 Linnoila, Markku 1; Affiliation:  1: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, 9000 Rockville Pike, Building 10, Room 3B19, Bethesda, Maryland 20892.; Source Info: 1993, Vol. 19 Issue 3, p359; Subject Term: ALCOHOLISM; Subject Term: SUBSTANCE abuse; Subject Term: DRINKING of alcoholic beverages; Subject Term: STIMULANTS; Subject Term: MECLOFENOXATE; Subject Term: UNITED States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shopland, Donald R.
T1  - Smoking Control in the 1990s: A National Cancer Institute Model for Change.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/09//
VL  - 83
IS  - 9
M3  - Article
SP  - 1208
EP  - 1210
PB  - American Public Health Association
SN  - 00900036
AB  - The article offers information on a research plan adopted by the U.S. National Cancer Institute to develop, test and spread effective smoking prevention and cessation interventions in the U.S. A number of smoking intervention trials were funded between 1984 and 1993. The institute also launched the Community Intervention Trial for Smoking Cessation to assess the effectiveness of these trials. The research also gave way to the culmination of the American Stop Smoking Intervention Study for Cancer Prevention.
KW  - RESEARCH
KW  - SMOKING cessation
KW  - CANCER prevention
KW  - SMOKING
KW  - UNITED States
KW  - NATIONAL Cancer Institute (U.S.)
N1  - Accession Number: 9401110366; Shopland, Donald R. 1; Affiliation:  1: Smoking and Tobacco Control Program, National Cancer Institute, Bethesda, MD.; Source Info: Sep93, Vol. 83 Issue 9, p1208; Subject Term: RESEARCH; Subject Term: SMOKING cessation; Subject Term: CANCER prevention; Subject Term: SMOKING; Subject Term: UNITED States; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Novikov, Ilya D.
AU  - Ruskin, Paul E.
AU  - Korn, Edward L.
AU  - Graubard, Barry I.
T1  - Bias in Weighted vs Unweighted Estimates.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/09//
VL  - 83
IS  - 9
M3  - Letter
SP  - 1351
EP  - 1351
PB  - American Public Health Association
SN  - 00900036
AB  - Two letters to the editor are presented in response to the article "Epidemiologic Studies Utilizing Surveys: Accounting for the Sampling Design," by E. L. Korn and B. I. Graubard in a 1991 issue and a response by the authors to the letter by Ilya D. Novikov and colleagues.
KW  - LETTERS to the editor
KW  - EPIDEMIOLOGY
KW  - ESTIMATION theory
KW  - SURVEYS
KW  - SAMPLING (Statistics)
N1  - Accession Number: 20691402; Novikov, Ilya D. 1 Ruskin, Paul E. 2 Korn, Edward L. 3 Graubard, Barry I.; Affiliation:  1: Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel Hashomer, Israel  2: University of Maryland, Baltimore  3: Biometric Research Branch, EPN-739, National Cancer Institute, Bethesda, MD 20892; Source Info: Sep93, Vol. 83 Issue 9, p1351; Subject Term: LETTERS to the editor; Subject Term: EPIDEMIOLOGY; Subject Term: ESTIMATION theory; Subject Term: SURVEYS; Subject Term: SAMPLING (Statistics); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 8/9p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fujimoto, Wataru
AU  - Marvin, Keith W.
AU  - George, Margaret D.
AU  - Celli, Giulia
AU  - Darwiche, Nadine
AU  - de Luca, Luigi M.
AU  - Jetten, Anton M.
T1  - Expression of Cornifin in Squamous Differentiating Epithelial Tissues, Including Psoriatic and Retinoic Acid-Treated Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/09//
VL  - 101
IS  - 3
M3  - Article
SP  - 268
EP  - 274
SN  - 0022202X
AB  - The expression of cornifin, a putative cross-linked envelope precursor, was investigated in several squamous differentiating tissues by <em>in situ</em> hybridization and immunohistochemical analysis. Confirm mRNA and protein, which are absent in the normal mucociliary tracheal epithelium, are induced in the suprabasal layers of the squamous metaplastic tracheal epithelium of vitamin A - deficient hamsters. Similar to the induction of squamous metaplasia <em>in vivo</em>, culture of rabbit tracheal cells in the absence of retinoids results in squamous differentiation and expression of cornifin. This induction of cornifin expression is suppressed by retinoic acid and several of its analogs. Cornifin mRNA and protein are also detected in the suprabasal layers of the squamous epithelium of rabbit esophagus and tongue. The distribution of cornifin in human epidermis was compared with that of two other crosslinked envelope precursor proteins, involucrin and loricrin. The localization of cornifin and involucrin is very similar. Both are induced in the spinous layer and appear at an earlier stage during epidermal differentiation than loricrin. The expression of cornifin is greatly increased in psoriatic skin. Cornifin mRNA is barely detectable in normal epidermis, whereas it is present at relatively high levels in the suprabasal layers of psoriatic epidermis. Topical treatment with RA results in thickening of the skin and increases the level of cornifin mRNA and protein in the upper spinous layers of mouse skin. Cornifin expression correlates generally with squamous differentiation in a variety of tissues and is abnormally regulated in psoriatic skin and in skin treated topically with retinoic acid. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOHISTOCHEMISTRY
KW  - PROTEIN crosslinking
KW  - RNA
KW  - TRACHEA
KW  - EPITHELIUM
KW  - PSORIASIS
KW  - crosslinked envelope.
KW  - Involucrin
KW  - loricrin
KW  - trachea
N1  - Accession Number: 12365200; Fujimoto, Wataru 1 Marvin, Keith W. 1 George, Margaret D. 1 Celli, Giulia 2 Darwiche, Nadine 2 de Luca, Luigi M. 2 Jetten, Anton M. 1; Affiliation:  1: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.  2: Laboratory of Cellular Carcinogenesis and Tumor Promotion, Differentiation Control Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep93, Vol. 101 Issue 3, p268; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: PROTEIN crosslinking; Subject Term: RNA; Subject Term: TRACHEA; Subject Term: EPITHELIUM; Subject Term: PSORIASIS; Author-Supplied Keyword: crosslinked envelope.; Author-Supplied Keyword: Involucrin; Author-Supplied Keyword: loricrin; Author-Supplied Keyword: trachea; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12365200
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McNeely, M. Carol
AU  - Lawley, Thomas J.
AU  - Harvath, Liana
T1  - Monoclonal Antibody Modulates Human Neutrophil Chemotaxis to N-formyl-Methionyl-Leucyl-Phenylalanine (fMLP).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/09//
VL  - 101
IS  - 3
M3  - Article
SP  - 377
EP  - 382
SN  - 0022202X
AB  - Utilizing standard hybridoma techniques and a neutrophil chemotaxis assay for screening we produced a mouse monoclonal IgM antibody, 59/4, selected for specific inhibition of human neutrophil chemotaxis to the N-formyl-methionyleucyl- phenylalanine peptide (fMLP). Antibody 59/4 inhibited neutrophil chemotaxis to fMLP, but not human C5a or leukotriene B4. The antibody exhibited specific homogeneous binding to PMNs, heterogeneous binding to monocytes, and did not bind to lymphocytes in a pattern similar to the profile of N-formyl peptide binding in flow cytometric analysis. The antibody did not inhibit the binding of fluorescein-conjugated fMLPK or fML(³H)P ligands to neutrophils in flow cytometric or competitive binding assays. Other neutrophil functions including mycloperoxidase release and rosette formation with immunoglobulin or immunoglobulin C3b-coated sheep erythrocytes were not affected in the presence of antibody 59/4. These results suggest that 59/4 specifically inhibits chemotaxis to fMLP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYBRIDOMAS
KW  - CHEMOTAXIS
KW  - PEPTIDES
KW  - MONOCYTES
KW  - IMMUNOGLOBULINS
KW  - BINDING sites (Biochemistry)
N1  - Accession Number: 12365592; McNeely, M. Carol 1 Lawley, Thomas J. 2 Harvath, Liana 3; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institute of Health, Atlanta, Georgia.  2: Department of Dermatology, Emory University, Atlanta, Georgia.  3: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Sep93, Vol. 101 Issue 3, p377; Subject Term: HYBRIDOMAS; Subject Term: CHEMOTAXIS; Subject Term: PEPTIDES; Subject Term: MONOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: BINDING sites (Biochemistry); Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12365592
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105851769
T1  - Recommendations on prophylaxis and therapy for disseminated Mycobacterium avium complex disease in patients infected with the human immunodeficiency virus. Public Health Service Task Force on Prophylaxis and Therapy for Mycobacterium avium Complex.
AU  - Masur H
Y1  - 1993/09/16/
N1  - Accession Number: 105851769. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; commentary; practice guidelines. Original Study: Nightingale SD, Cameron DW, Gordin FM, Sullam PM, Cohn DL, Chaisson RE, et al. Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. (N ENGL J MED) 9/16/93; 329 (12): 828-833. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - AIDS-Related Opportunistic Infections -- Prevention and Control
KW  - Mycobacterium Avium-Intracellulare Infection -- Prevention and Control
KW  - Adult
KW  - Antibiotics -- Therapeutic Use
KW  - Antiinfective Agents
KW  - Antiinfective Agents -- Therapeutic Use
KW  - Child
KW  - Gram-Positive Bacteria
KW  - Infant
KW  - Microbial Culture and Sensitivity Tests
KW  - Mycobacterium Avium-Intracellulare Infection -- Diagnosis
KW  - Mycobacterium Avium-Intracellulare Infection -- Therapy
SP  - 898
EP  - 904
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 329
IS  - 12
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 8395019.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Forman, Michele R.
AU  - Lanza, Elaine
AU  - Lee-Chen Yong
AU  - Holden, Joanne M.
AU  - Graubard, Barry I.
AU  - Beecher, Gary R.
AU  - Melitz, Marc
AU  - Brown, Ellen D.
AU  - Smith, J. Cecil
T1  - The correlation between two dietary assessments of carotenoid intake and plasma carotenoid concentrations: application of a carotenoid food-composition database.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1993/10//
VL  - 58
IS  - 4
M3  - Article
SP  - 519
EP  - 524
SN  - 00029165
AB  - A newly available carotenoid food-composition database providing specific carotenoid values for > 2300 foods was linked to dietary data on 57 male nonsmokers to examine the association between dietary carotenoid intake and plasma carotenoid concentrations over 3 wk when free-living. Carotenoid intake was estimated from a food-frequency questionnaire (FFQ) and 7 d of food diaries with concurrent analysis of plasma carotenoid concentrations. After adjustment for energy intake, percentage of energy from alcohol, and plasma lipid concentrations, significant diet-plasma correlations for the FFQ and the food diaries (FD) included a-carotene (r = 0.29 and 0.43), β-carotene (r = 0.36 FFQ only), β-cryptoxanthin (r = 0.46 and 0.44), lutein (r = 0.44 FD only), and lycopene (r = 0.53 FD only). Dietary carotenoid intakes were associated with plasma carotenoid concentrations for all the carotenoids except for carotene when food diaries were used whereas the diet-plasma correlation for the provitamin A carotenoids were consistently significant when the FFQ was used. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carotene in the blood
KW  - Food -- Composition
KW  - Provitamins
KW  - Blood lipids
KW  - Food diaries
KW  - Carotenoids
KW  - diet
KW  - plasma
N1  - Accession Number: 94484475; Forman, Michele R. 1,2,3; Lanza, Elaine 1,2,3; Lee-Chen Yong 1,2,3; Holden, Joanne M. 1,2,3; Graubard, Barry I. 1,2,3; Beecher, Gary R. 1,2,3; Melitz, Marc 1,2,3; Brown, Ellen D. 1,2,3; Smith, J. Cecil 1,2,3; Affiliations: 1: Cancer Prevention Studies Branch, Cancer Prevention Research Program, Division of Cancer Prevention and Control, National Cancer Institute, Rockville, MD; 2: Beltsville Human Nutrition Facility, Agriculture Research Service Center, US Department of Agriculture, Beltsville, MD; 3: Information Management Services, Silver Spring, MD; Issue Info: Oct1993, Vol. 58 Issue 4, p519; Subject Term: Carotene in the blood; Subject Term: Food -- Composition; Subject Term: Provitamins; Subject Term: Blood lipids; Subject Term: Food diaries; Author-Supplied Keyword: Carotenoids; Author-Supplied Keyword: diet; Author-Supplied Keyword: plasma; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rasmussen, Kathlyn L. R.
T1  - Celebration of Synthesis: An Unusual Festschrift for Robert Hinde.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1993/10//
VL  - 31
IS  - 2
M3  - Book Review
SP  - 141
EP  - 146
SN  - 02752565
AB  - Reviews the book "The Development and Integration of Behavior: Essays in Honour of Robert Hinde," edited by Patrick Bateson.
KW  - ANIMAL behavior
KW  - NONFICTION
KW  - BATESON, Patrick
KW  - DEVELOPMENT & Integration of Behavior, The (Book)
N1  - Accession Number: 12323336; Rasmussen, Kathlyn L. R. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1993, Vol. 31 Issue 2, p141; Subject Term: ANIMAL behavior; Subject Term: NONFICTION; Reviews & Products: DEVELOPMENT & Integration of Behavior, The (Book); People: BATESON, Patrick; Number of Pages: 6p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Biggar, Robert J.
T1  - Editorial: When Ideals Meet Reality -- The Global Challenge HIV/AIDS.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/10//
VL  - 83
IS  - 10
M3  - Editorial
SP  - 1383
EP  - 1383
PB  - American Public Health Association
SN  - 00900036
AB  - This article comments on an article by Kevin De Dock and colleagues about the establishment of programs that provide treatment to patients with AIDS in developing countries. The authors warned that researchers studying AIDS in Africa will be blamed for having little interest in Africans with AIDS. They also insist that the low quality of medical care for people with AIDS in the developing countries is unjust. Based on a survey, there is less spending for the prevention of AIDS and HIV in developing countries compared to other illnesses.
KW  - HEALTH promotion
KW  - AIDS (Disease) -- Treatment
KW  - MEDICAL care costs
KW  - PATIENTS
KW  - DEVELOPING countries
N1  - Accession Number: 9401102981; Biggar, Robert J. 1; Affiliation:  1: Viral Epidemiology Branch of the National Cancer Institute, Bethesda, MD; Source Info: Oct93, Vol. 83 Issue 10, p1383; Subject Term: HEALTH promotion; Subject Term: AIDS (Disease) -- Treatment; Subject Term: MEDICAL care costs; Subject Term: PATIENTS; Subject Term: DEVELOPING countries; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simonsick, Eleanor M.
AU  - Lafferty, Mary E.
AU  - Phillips, Caroline L.
AU  - De Leon, Carlos F. Mendes
AU  - Kasl, Stanislav V.
AU  - Seeman, Teresa E.
AU  - Fillenbaum, Gerda
AU  - Hebert, Patricia
AU  - Lemke, Jon H.
T1  - Risk Due to Inactivity in Physically Capable Older Adults.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/10//
VL  - 83
IS  - 10
M3  - Article
SP  - 1443
EP  - 1443
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined the association between recreational physical activity among physically capable older adults and functional status, incidence of selected chronic conditions, and mortality over 3 and 6 years. Methods. Data are from three sites of the Established Populations for Epidemiologic Studies of the Elderly. Results. A high level of recreational physical activity reduced the likelihood of mortality over both 3 and 6 years. Moderate to high activity reduced the risk of physical impairments over 3 years: this effect diminishes after 6 years. A consistent relationship between activity and new myocardial infarction or stroke or the incidence of diabetes or angina was not found after 3 or 6 years. Conclusions. Findings suggest that physical activity offers benefits to physically capable older adults, primarily in reducing the risk of functional decline and mortality. Future work must use more objective and quantifiable measures of activity and assess changes in activity levels over time. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RECREATION
KW  - PHYSICAL fitness
KW  - OLDER people
KW  - CHRONIC diseases
KW  - MORTALITY
KW  - Functional States
N1  - Accession Number: 9401102993; Simonsick, Eleanor M. 1 Lafferty, Mary E. 1 Phillips, Caroline L. 1 De Leon, Carlos F. Mendes 2 Kasl, Stanislav V. 2 Seeman, Teresa E. 2 Fillenbaum, Gerda 3 Hebert, Patricia 4 Lemke, Jon H. 5; Affiliation:  1: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Md.  2: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn.  3: Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC  4: Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Mass.  5: Department of Preventive Medicine, University of Iowa, Iowa City; Source Info: Oct93, Vol. 83 Issue 10, p1443; Subject Term: RECREATION; Subject Term: PHYSICAL fitness; Subject Term: OLDER people; Subject Term: CHRONIC diseases; Subject Term: MORTALITY; Author-Supplied Keyword: Functional States; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Long, Jeffrey C.
T1  - HUMAN MOLECULAR PHYLOGENETICS.
JO  - Annual Review of Anthropology
JF  - Annual Review of Anthropology
Y1  - 1993/10//
VL  - 22
IS  - 1
M3  - Article
SP  - 251
EP  - 272
PB  - Annual Reviews Inc.
SN  - 00846570
AB  - The article discusses the controversy surrounding molecular phylogenetics and the paleontological debate regarding modern human origins. The core assumption of phylogenetics is that current populations can be connected through a series of bifurcations back to a sole ancestral population. The genetic evidence for replacement has been challenged, including misapplication of statistical methods in crucial analyses. The resolution of the replacement and multiregional contrasting views will be vital to general evolutionary biology and is the key to understanding the adaptive evolution of the human species.
KW  - PHYLOGENY
KW  - EVOLUTION (Biology)
KW  - HUMAN population genetics
KW  - POPULATION genetics
KW  - HUMAN genetics
KW  - HUMAN molecular genetics
KW  - CLADISTIC analysis
KW  - POPULATION dynamics
KW  - POPULATION
KW  - evoluiton
KW  - genetics
KW  - mtDNA
KW  - nDNA
KW  - phylogenetics
N1  - Accession Number: 9403093128; Long, Jeffrey C. 1; Affiliation:  1: Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bcthcsda, Maryland 20892 and Department of Anthropology, University of New Mexico, Albuquerque, New Mexico 87131; Source Info: 1993, Vol. 22 Issue 1, p251; Subject Term: PHYLOGENY; Subject Term: EVOLUTION (Biology); Subject Term: HUMAN population genetics; Subject Term: POPULATION genetics; Subject Term: HUMAN genetics; Subject Term: HUMAN molecular genetics; Subject Term: CLADISTIC analysis; Subject Term: POPULATION dynamics; Subject Term: POPULATION; Author-Supplied Keyword: evoluiton; Author-Supplied Keyword: genetics; Author-Supplied Keyword: mtDNA; Author-Supplied Keyword: nDNA; Author-Supplied Keyword: phylogenetics; Number of Pages: 22p; Illustrations: 4 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McLachlan, John A.
T1  - Functional Toxicology A New Approach to Detect Biologically Active Xenobiotics.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1993/10//
VL  - 101
IS  - 5
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Reports on the development of various approaches to detect biologically active xenobiotics. Screening of chemicals for activity in vitro using a panel of human or animal cells that have been transfected with a specific receptor and reporter gene; Benefits of classifying chemicals by their function in vitro.
KW  - Xenobiotics
KW  - Bioactive compounds
KW  - Chemicals
KW  - Biochemistry
KW  - Cells
KW  - Genes
N1  - Accession Number: 13013305; McLachlan, John A. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA.; Issue Info: Oct1993, Vol. 101 Issue 5, p1; Thesaurus Term: Xenobiotics; Thesaurus Term: Bioactive compounds; Subject Term: Chemicals; Subject Term: Biochemistry; Subject Term: Cells; Subject Term: Genes; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Wachsman, Joseph T.
AU  - Bristol, Douglas W.
AU  - Spalding, Judson
AU  - Shelby, Michael
AU  - Tennant, Raymond W.
T1  - Predicting chemical Carcinogenesis in Rodents.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1993/10//
VL  - 101
IS  - 5
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Predicts chemical carcinogenesis in rodent bioassay. Importance of the bioassay in testing chemicals each year; Predictive methods which draw various kinds of information and test results.
KW  - Biological assay
KW  - Animal models in research
KW  - Carcinogenesis -- Animal models
KW  - Chemicals
KW  - Rats as laboratory animals
N1  - Accession Number: 13013319; Wachsman, Joseph T. 1; Bristol, Douglas W. 1; Spalding, Judson 1; Shelby, Michael 1; Tennant, Raymond W. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA.; Issue Info: Oct1993, Vol. 101 Issue 5, p1; Thesaurus Term: Biological assay; Thesaurus Term: Animal models in research; Subject Term: Carcinogenesis -- Animal models; Subject Term: Chemicals; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Taylor-Brown, Susan
AU  - Wiener, Lori
T1  - Making Videotapes of HIV-Infected Women for Their Children.
JO  - Families in Society
JF  - Families in Society
Y1  - 1993/10//
VL  - 74
IS  - 8
M3  - Article
SP  - 468
EP  - 480
SN  - 10443894
AB  - In the United States, the majority of HIV-infected women are of childbearing age and have dependent children. Seropositivity for HIV threatens a woman's ability to care for her children into adulthood. In an effort to address the pain these women feel regarding their parental role, the authors helped HIV-infected women develop videotapes for their children. This article describes the therapeutic application of videotapes for HIV-infected women with dependent children. Case studies illustrate how women are prepared to make a tape for their children and the taping process as well as examine issues practitioners confront before, during, and after the taping session. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Families in Society is the property of Alliance for Children & Families and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VIDEO recording
KW  - PARENTING
KW  - HIV-positive women
KW  - CHILDREN of AIDS patients
KW  - MOTHER & child
N1  - Accession Number: 9312282025; Taylor-Brown, Susan 1 Wiener, Lori 2; Affiliation:  1: Assistant Professor, School of Social Work, Syracuse University, Syracuse, New York  2: Coordinator, Pediatric HIV Psychosocial Support Program, National Cancer Institute, Bethesda, Maryland; Source Info: Oct93, Vol. 74 Issue 8, p468; Subject Term: VIDEO recording; Subject Term: PARENTING; Subject Term: HIV-positive women; Subject Term: CHILDREN of AIDS patients; Subject Term: MOTHER & child; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Song, L.
AU  - Adler, W.H.
AU  - Chung, S.
AU  - Y. Ho Kim
AU  - TenBrook, J.
AU  - Collins, G.D.
AU  - Nagel, J.E.
T1  - Concurrent strong tyrosine phosphorylation of a 42,000 MW ERK and a 100,000 MW protein is associated with IL-2 production in human Jurkat T cells.
JO  - Immunology
JF  - Immunology
Y1  - 1993/10//
VL  - 80
IS  - 2
M3  - Article
SP  - 222
EP  - 228
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The tyrosine phosphorylated protein(s) responsible for the signalling for interleukin-2 (IL-2) production has not been clearly defined. In this study, the relationship between IL-2 production and the protein tyrosine phosphorylation pattern of human Jurkat T cells was investigated using phosphotyrosine immunoblotting analysis. With anti-CD3 or anti-CD2 activation the cells showed only a low (anti-CD3) or a moderate (anti-CD2) level of tyrosine phosphorylation of a 42,000 MW external signal-regulated kinase (ERK), which was accompanied by undetectable (anti-CD3) or low level (anti-CD2) IL-2 production. In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein. PMA alone, which induced high levels of tyrosine phosphorylation of the ERK protein, neither induced any detectable IL-2 nor increased the level of tyrosine phosphorylation of the 100,000 MW protein. These observations suggest that concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein may be required for IL-2 production. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHORYLATION
KW  - CHEMICAL reactions
KW  - TYROSINE
KW  - INTERLEUKINS
KW  - T cells
KW  - LYMPHOCYTES
N1  - Accession Number: 13606197; Song, L. 1 Adler, W.H. 1 Chung, S. 1 Y. Ho Kim 1 TenBrook, J. 1 Collins, G.D. 1 Nagel, J.E. 1; Affiliation:  1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, Maryland, U.S.A.; Source Info: Oct93, Vol. 80 Issue 2, p222; Subject Term: PHOSPHORYLATION; Subject Term: CHEMICAL reactions; Subject Term: TYROSINE; Subject Term: INTERLEUKINS; Subject Term: T cells; Subject Term: LYMPHOCYTES; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Makino, M.
AU  - Winkler, D.F.
AU  - Wunderlich, J.
AU  - Hartley, J.W.
AU  - Morse, H.C.
AU  - Holmes, K.L.
T1  - High expression of NK-1.1 antigen is induced by infection with murine AIDS virus.
JO  - Immunology
JF  - Immunology
Y1  - 1993/10//
VL  - 80
IS  - 2
M3  - Article
SP  - 319
EP  - 325
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Spleen cells from mice infected with LP-BM5 MuLV, a causative agent of murine acquired immunodeficiency syndrome (MAIDS), were tested for frequency ofNK-l.1+ cells and natural killer (NK) activity. During the first 3 weeks following infection, NK activity was well conserved, but by 9-12 weeks post-infection (p.i.), killer activity was depressed; however, the frequency of NK-1.1+ cells increased within 4 weeks of infection and remained elevated thereafter, even following the decline in functional killing activity. Since the absolute number of NK-1.1+ cells increased after infection, the ability of each NK- 1.1+ cell to kill the targets seems drastically impaired. Extraordinary expansion of N K-1.1-positive cells was induced by infection with LP-BM 5-defective virus (BM 5Def), a crucial element for MAIDS induction, but not with a helper non-pathogenic virus. With advance of MAIDS the NK-1.1 antigen (Ag) was preferentially expressed on B2204 and Thy-1+ cells, in contrast to CD4+ and CD8 + cells, and among activated large cells a higher proportion was NK-1.1+ than NK-1.1 . Mice with graft-versus-host disease (GVHD) due to class Il major histocompatibility complex (MHC) Ag disparity showed a high frequency of NK-1.1 expression in association with other phenotypic alterations, very similar to those seen in mice with MAIDS. In contrast, B6-1pr/lpr mice developed similar activation of B cells but did not exhibit enhanced expression of the NK-1. I marker. Thus, enhanced expression of the NK-1. l Ag might be associated with chronic activation of lymphocytes through a common but not universal pathway. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - SPLEEN
KW  - GRAFT versus host disease
KW  - MAJOR histocompatibility complex
KW  - HLA histocompatibility antigens
KW  - LEUCOCYTES
N1  - Accession Number: 13606774; Makino, M. 1,2 Winkler, D.F. 3 Wunderlich, J. 3 Hartley, J.W. 2 Morse, H.C. 2 Holmes, K.L. 4; Affiliation:  1: Department of Bacterial and Blood Products, National Institutes of Health, Tokyo, Japan  2: Laboratory of Immunopathology  3: Experimental Immunology Branch  4: Biology Resources Branch, NIH, Bethesda, Maryland, U.S.A.; Source Info: Oct93, Vol. 80 Issue 2, p319; Subject Term: CELLS; Subject Term: SPLEEN; Subject Term: GRAFT versus host disease; Subject Term: MAJOR histocompatibility complex; Subject Term: HLA histocompatibility antigens; Subject Term: LEUCOCYTES; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bachrach, Christine A.
AU  - Clogg, Clifford C.
AU  - Carver, Karen
T1  - Outcomes of Early Childbearing: Summary of a Conference.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1993/10//
VL  - 3
IS  - 4
M3  - Article
SP  - 337
EP  - 348
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - The article presents the summary of a conference on Outcomes of Early childbearing: An Appraisal of Recent Evidence, held in May 1992.  Adolescent childbearing became a focus of policy concern during the 1970s because of the disadvantaged condition of many adolescent mothers, their increasing numbers and the increasing proportion of these mothers who were unmarried. This heightened policy interest has led to much research on the antecedents and consequences of early childbearing.
KW  - CONFERENCES & conventions
KW  - TEENAGE mothers
KW  - CHILDBIRTH
KW  - UNMARRIED mothers
KW  - ILLEGITIMACY
N1  - Accession Number: 11301281; Bachrach, Christine A. 1 Clogg, Clifford C. 2 Carver, Karen 1; Affiliation:  1: National Institute of Child Health and Human Development.  2: Department of Sociology, Penn State University.; Source Info: 1993, Vol. 3 Issue 4, p337; Subject Term: CONFERENCES & conventions; Subject Term: TEENAGE mothers; Subject Term: CHILDBIRTH; Subject Term: UNMARRIED mothers; Subject Term: ILLEGITIMACY; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1532-7795.ep11301281
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Baldwin, Wendy
T1  - The Consequences of Early Childbearing: A Perspective.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1993/10//
VL  - 3
IS  - 4
M3  - Article
SP  - 349
EP  - 352
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - The article focuses on the consequences of early childbearing. Early childbearers were not the most advantaged or motivated young women but, even controlling for past aptitude, goals, and grades, an early birth was an additional hurdle. Early findings indicated that babies of young mothers are harmed less by the young age of the mother than by the social concomitants of early childbearing. Studies showed that with high quality care, birthweight outcomes were no worse than for older women.
KW  - CHILDBIRTH
KW  - TEENAGE mothers
KW  - MOTHERHOOD
KW  - MATERNAL age
KW  - WOMEN -- Health
N1  - Accession Number: 11301300; Baldwin, Wendy 1; Affiliation:  1: National Institute of Child Health and Human Development.; Source Info: 1993, Vol. 3 Issue 4, p349; Subject Term: CHILDBIRTH; Subject Term: TEENAGE mothers; Subject Term: MOTHERHOOD; Subject Term: MATERNAL age; Subject Term: WOMEN -- Health; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1532-7795.ep11301300
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Oppenheim, Amos B.
AU  - Rudd, Kenneth E.
AU  - Mendelson, Itai
AU  - Teff, Dinah
T1  - Integration host factor binds to a unique class of complex repetitive extragenic DNA sequences in Escherichia coli.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/10//
VL  - 10
IS  - 1
M3  - Article
SP  - 113
EP  - 122
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Interspersed repeated DNA sequences are characteristic features of both prokaryotic and eukaryotic genomes. REP sequences are defined as conserved repetitive extragenic palindromic sequences and are found in <em>Escherichia coli, Salmonella typhimurium</em> and other closely related enteric bacteria. These REP sequences may participate in the folding of the bacterial chromosome. In this work we describe a unique class of 28 conserved complex REP clusters, about 100bp long, in which two inverted REPs are separated by a singular integration host factor (IHF) recognition sequence. We term these sequences RIP (for repetitive IHF-binding palindromic) elements and demonstrate that IHF binds to them specifically. It is estimated that there are about 70 RIP elements in <em>E. coli</em>. Our analysis shows that the RIP elements are evenly distributed around the bacterial chromosome. The possible function of the RIP element is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Prokaryotes
KW  - Eukaryotic cells
KW  - Escherichia coli
KW  - Nucleotide sequence
KW  - DNA
KW  - Genomes
KW  - Salmonella typhimurium
KW  - Chromosomes
N1  - Accession Number: 16578079; Oppenheim, Amos B. 1; Rudd, Kenneth E. 2; Mendelson, Itai 3; Teff, Dinah 1; Affiliations: 1: Department of Molecular Genetics, The Hebrew University, Hadassah Medical School, Jerusalem 91010, Israel; 2: National Center for Biotechnology Information, National Library of Medicine. National Institutes of Health, Bethesda, Maryland 20894, USA; 3: Israel Institute for Biological Research, PO Box 19, Nes Ziona 70200, Israel; Issue Info: Oct1993, Vol. 10 Issue 1, p113; Thesaurus Term: Prokaryotes; Thesaurus Term: Eukaryotic cells; Thesaurus Term: Escherichia coli; Subject Term: Nucleotide sequence; Subject Term: DNA; Subject Term: Genomes; Subject Term: Salmonella typhimurium; Subject Term: Chromosomes; Number of Pages: 10p; Illustrations: 4 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Cavedon, K.
AU  - London, J.
T1  - Adhesin degradation: a possible function for a <em>Prevotella loescheii</em> protease?
JO  - Oral Microbiology & Immunology
JF  - Oral Microbiology & Immunology
Y1  - 1993/10//
VL  - 8
IS  - 5
M3  - Article
SP  - 283
EP  - 287
SN  - 09020055
AB  - <em>Prevotella Ioescheii</em> PK1295 produces at least 3 proteases that are separable by isoelectric focusing. One of these proteases, an enzyme with an isoelectric point at 8.5 and an Mr of 36,000, hydrolyzes the fimbria-associated adhesin on <em>P. loescheii</em> responsible for coaggregation with <em>Streptococcus oralis</em> 34, as well as gelatin, casein and fibrin. The action of this protease may contribute to the detachment of <em>P. loescheii</em> from its streptococcal coaggregation partner and provide a mechanism for bacterial relocation in dental plaque. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oral Microbiology & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Microbial aggregation
KW  - Proteolytic enzymes
KW  - Hydrolysis
KW  - Dental plaque
KW  - Isoelectric focusing
KW  - Pili (Microbiology)
KW  - Streptococcus
KW  - <em>Prevotella Ioescheii</em>
KW  - fimbria-associated adhesin
KW  - isoelectric focusing
KW  - protease activity
N1  - Accession Number: 12555761; Cavedon, K. 1; London, J. 2; Affiliations: 1: Forsyth Dental Center, 140 The Fenway, Boston, MA 02115, USA.; 2: Laboratory of Microbial Ecology, National Institute of Dental Research, US National Institutes of Health, Bethesda, Maryland, USA.; Issue Info: Oct1993, Vol. 8 Issue 5, p283; Thesaurus Term: Microbial aggregation; Thesaurus Term: Proteolytic enzymes; Thesaurus Term: Hydrolysis; Subject Term: Dental plaque; Subject Term: Isoelectric focusing; Subject Term: Pili (Microbiology); Subject Term: Streptococcus; Author-Supplied Keyword: <em>Prevotella Ioescheii</em>; Author-Supplied Keyword: fimbria-associated adhesin; Author-Supplied Keyword: isoelectric focusing; Author-Supplied Keyword: protease activity; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1399-302X.ep12555761
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104782592
T1  - Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys.
AU  - Thomas, D A
AU  - Anton, F
AU  - Kenshalo Jr, D R
AU  - Williams, G M
AU  - Dubner, R
Y1  - 1993/10//1993 Oct
N1  - Accession Number: 104782592. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Behavior, Animal
KW  - Norepinephrine -- Physiology
KW  - Pain -- Psychosocial Factors
KW  - Receptors, Cell Surface -- Physiology
KW  - Adrenergic Antagonists
KW  - Adrenergic Alpha-Agonists -- Pharmacodynamics
KW  - Adrenergic Alpha-Antagonists -- Pharmacodynamics
KW  - Animals
KW  - Clonidine -- Analogs and Derivatives
KW  - Clonidine -- Pharmacodynamics
KW  - Dioxins -- Pharmacodynamics
KW  - Electrophysiology
KW  - Heat
KW  - Primates
KW  - Male
KW  - Brain Stem -- Physiology
KW  - Injections
KW  - Naloxone -- Pharmacodynamics
KW  - Physical Stimulation
SP  - 63
EP  - 70
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 55
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 7904058.
DO  - 10.1016/0304-3959(93)90185-R
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105851076
T1  - Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. An overview of results from randomized controlled trials.
AU  - Teo KK
AU  - Yusuf S
AU  - Furberg CD
AU  - Teo, K K
AU  - Yusuf, S
AU  - Furberg, C D
Y1  - 1993/10/06/
N1  - Accession Number: 105851076. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article; research; randomized controlled trial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Antiarrhythmia Agents -- Therapeutic Use
KW  - Myocardial Infarction -- Drug Therapy
KW  - Antiarrhythmia Agents -- Classification
KW  - Randomized Controlled Trials
KW  - Myocardial Infarction -- Mortality
KW  - Survival Analysis
KW  - Human
SP  - 1589
EP  - 1595
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 270
IS  - 13
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To investigate the effects of prophylactic therapy with antiarrhythmic agents on mortality in patients with myocardial infarction.Data Sources and Study Selection: Data were obtained from all completed, published or unpublished, randomized, parallel controlled trials of antiarrhythmic agents, regardless of sample size. Investigators were contacted for data on patients excluded after randomization.Data Extraction: Data on mortality were extracted by one author and confirmed where necessary by the others.Data Synthesis: Mortality data from 138 trials on 98,000 patients were combined by the Yusuf-Peto adaptation of the Mantel-Haenszel method. There were 660 deaths among 11,712 patients allocated to receive class I agents and 571 deaths among 11,517 corresponding control patients (51 trials: odds ratio [OR], 1.14; 95% confidence interval [CI], 1.01 to 1.28; P = .03). Of 26,973 patients allocated to receive beta-blockers (class II agents), 1464 died compared with 1727 deaths among 26,295 control patients (55 trials: OR, 0.81; 95% CI, 0.75 to 0.87; P = .00001). Of 778 patients allocated to receive amiodarone (a class III agent), 77 died compared with 101 deaths in 779 control patients (eight trials: OR, 0.71; 95% CI, 0.51 to 0.97; P = .03). There were 982 deaths in 10,154 patients allocated to receive a class IV agent (calcium channel blockers) and 949 deaths in 10,188 control patients (24 trials: OR, 1.04; 95% CI, 0.95 to 1.14; P = .41).Conclusions: The routine use of class I antiarrhythmic agents after myocardial infarction is associated with increased mortality. beta-Blockers have been conclusively demonstrated to reduce mortality. The limited data on amiodarone appear promising. Data on calcium channel blockers remain unpromising.
SN  - 0098-7484
AD  - Clinical Trials Branch, National Heart, Lung, and Blood Institute, Bethesda, Md
AD  - Clinical Trials Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
U2  - PMID: 8371471.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105851803
T1  - Data torturing.
AU  - Mills JL
Y1  - 1993/10/14/
N1  - Accession Number: 105851803. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Data Analysis, Statistical
KW  - Confidence Intervals
KW  - Environmental Exposure
KW  - Probability
KW  - Study Design
KW  - Human
SP  - 1196
EP  - 1199
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 329
IS  - 16
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institute of Child Health and Human Development, Bethesda, MD 20892.
U2  - PMID: 8166792.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hinnebusch, Alan G.
T1  - Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/10/15/
VL  - 10
IS  - 2
M3  - Article
SP  - 215
EP  - 223
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Phosphorylation of the α subunit of eukaryotic initiation factor 2 (elF-2α) is one of the best-characterized mechanisms for down-regulating total protein synthesis in mammalian cells in response to various stress conditions. Recent work indicates that regulation of the <em>GCN4</em> gene of <em>Saccharomyces cerevisiae</em> by amino acid availability represents a gene-specific case of translational control by phosphorylation of elF-2α. Four short open reading frames in the leader of <em>GCN4</em> mRNA (uORFs) restrict the flow of scanning ribosomes from the cap site to the <em>GCN4</em> initiation codon. When amino acids are abundant, ribosomes translate the first uORF and reinitiate at one of the remaining uORFs in the leader, after which they dissociate from the mRNA. Under conditions of amino acid starvation, many ribosomes which have translated uORF1 fail to reinitiate at uORFs 2-4 and utilize the <em>GCN4</em> start codon instead. Failure to reinitiate at uORFs 2-4 in starved cells results from a reduction in the GTP-bound form of elF-2 that delivers charged initiator tRNAiMet to the ribosome. When the levels of elF-2·GTP·Met-tRNAiMet ternary complexes are low, many ribosomes will not rebind this critical initiation factor following translation of uORF1 until after scanning past uORF4, but before reaching <em>GCN4</em>. Phosphorylation of elF-2 by the protein kinase GCN2 decreases the concentration of elF-2·GTP·Met-tRNAiMet complexes by inhibiting the guanine nucleotide exchange factor for elF-2, which is the same mechanism utilized in mammalian cells to inhibit total protein synthesis by phosphorylation of elF-2. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Eukaryotic cells
KW  - Mammals
KW  - Ribosomes
KW  - Phosphorylation
KW  - Genetic regulation
KW  - Proteins
KW  - Saccharomyces cerevisiae
KW  - Cells
KW  - Amino acids
KW  - G proteins
N1  - Accession Number: 16575299; Hinnebusch, Alan G. 1; Affiliations: 1: Section on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Oct1993, Vol. 10 Issue 2, p215; Thesaurus Term: Eukaryotic cells; Thesaurus Term: Mammals; Thesaurus Term: Ribosomes; Subject Term: Phosphorylation; Subject Term: Genetic regulation; Subject Term: Proteins; Subject Term: Saccharomyces cerevisiae; Subject Term: Cells; Subject Term: Amino acids; Subject Term: G proteins; Number of Pages: 9p; Illustrations: 2 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Weickert, Michael J.
AU  - Adhya, Sankar
T1  - The galactose regulon of Escherichia coli.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/10/15/
VL  - 10
IS  - 2
M3  - Article
SP  - 245
EP  - 251
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Galactose transport and metabolism in <em>Escherichia coli</em> involves a multicomponent amphibolic pathway. Galactose transport is accomplished by two different galactose-specific transport systems. At least four of the genes and operons involved in galactose transport and metabolism have promoters containing similar regulatory sequences. These sequences are recognized by at least three regulators, Gal repressor (GalR), Gal isorepressor (GalS) and cAMP receptor protein (CRP), which modulate transcription from these promoters. The negative regulators, GalR and GalS, discriminate between utilization of the high-affinity (regulated by GalS) and low-affinity (regulated by GalR) transport systems, and modulate the expression of genes for galactose metabolism in an overlapping fashion. GalS is itself autogenously regulated and CRP dependent, while the gene for GalR is constitutive. The <em>gal</em> operon encoding the enzymes for galactose metabolism has two promoters regulated by CRP in opposite ways; one (<em>P</em>1) is stimulated and the other (<em>P</em>2) inhibited by CRP. Both promoters are strongly repressed by GalR but weakly by GalS. All but one of the constituent promoters of the <em>gal</em> regulon have two operators. The <em>gal</em> regulon has the potential to coordinate galactose metabolism and transport in a highly efficient manner, under a wide variety of conditions of galactose availability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Galactose
KW  - Operons
KW  - Cyclic adenylic acid
KW  - Genes
KW  - Proteins
KW  - Enzymes
N1  - Accession Number: 16575318; Weickert, Michael J. 1; Adhya, Sankar 2; Affiliations: 1: Somatogen Inc., 5797 Central Avenue, Boulder, Colorado 80301, USA; 2: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Oct1993, Vol. 10 Issue 2, p245; Thesaurus Term: Escherichia coli; Subject Term: Galactose; Subject Term: Operons; Subject Term: Cyclic adenylic acid; Subject Term: Genes; Subject Term: Proteins; Subject Term: Enzymes; Number of Pages: 7p; Illustrations: 4 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105851837
T1  - Clinical implications of the p53 tumor-suppressor gene.
AU  - Harris CC
AU  - Hollstein M
Y1  - 1993/10/28/
N1  - Accession Number: 105851837. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Neoplasms
KW  - Oncogenes
KW  - Proteins
KW  - Mutation
KW  - Neoplasms -- Diagnosis
KW  - Neoplasms -- Therapy
KW  - RNA
SP  - 1318
EP  - 1327
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 329
IS  - 18
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Cancer Institute, Laboratory of Human Carcinogenesis, Bethesda, Md. 20892.
U2  - PMID: 8413413.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104786346
T1  - Relative frequency of heavy drinking and the risk of alcohol dependence.
AU  - Dawson, D A
AU  - Archer, L D
Y1  - 1993/11//
N1  - Accession Number: 104786346. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Adolescence
KW  - Adult
KW  - Blacks
KW  - Age Factors
KW  - Educational Status
KW  - Ethanol
KW  - Female
KW  - Male
KW  - Risk Factors
KW  - Sex Factors
KW  - Substance Use Disorders
KW  - United States
SP  - 1509
EP  - 1518
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 11
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Data from a national representative sample of US adults were analyzed to determine the association between the relative frequency of heavy drinking (the proportion of drinking occasions on which 5+ drinks were consumed) and past-year alcohol dependence, adjusting for the influences of average ethanol intake and sociodemographic factors. Fifty-seven percent of current drinkers reported never drinking 5+ drinks, and 21% drank 5+ drinks at least once but on less than 10% of all drinking occasions. Nine percent reported drinking 5+ drinks on at least half of all drinking occasions. Average daily intake was positively correlated with the relative frequency of heavy drinking, and both consumption measures were positively associated with the risk of alcohol dependence. Increases in either relative frequency of heavy drinking or average ethanol intake reduced, but did not eliminate, the effect of the other on the risk of dependence. The excess risk of dependence associated with frequent heavy drinking varied among population subgroups and was increased by age, education, and female gender.
SN  - 0965-2140
AD  - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857.
U2  - PMID: 8286996.
DO  - 10.1111/j.1360-0443.1993.tb03136.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104786352
T1  - Structure and correlates of alcohol dependence in clinical samples in the United States and Russia.
AU  - Allen, J P
AU  - Fertig, J B
AU  - Towle, L H
AU  - Bryant, K
AU  - Altshuler, V B
AU  - Vrublevsky, A G
AU  - Valentik, Y V
Y1  - 1993/11//
N1  - Accession Number: 104786352. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Composite International Diagnostic Interview (CIDI). NLM UID: 9304118. 
KW  - Alcoholism -- Epidemiology
KW  - Ethanol
KW  - Substance Use Disorders -- Epidemiology
KW  - Adult
KW  - Alcohol Drinking
KW  - Alcoholism -- Diagnosis
KW  - Ethnological Research
KW  - Female
KW  - Human
KW  - Interview Guides
KW  - Male
KW  - Psychological Tests
KW  - Russia
KW  - Severity of Illness Indices
KW  - United States
SP  - 1535
EP  - 1543
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 11
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Using items from the Composite International Diagnostic Interview, dimensionality of the alcohol dependence syndrome was assessed in clinical samples in the United States and Russia. In both groups, a single-factor model provided a high degree of goodness of fit thus demonstrating cross-cultural coherence of the construct. The item dealing with narrowing of the drinking repertoire is most disparate in each sample. Severity of alcohol consequences was moderately related to alcohol dependence in both samples. Demographic variables, however, correlated less with severity of consequences. After the effects of severity of dependence and demographics were removed, quantity/frequency of recent alcohol consumption did not contribute to severity of consequences. Country, however, remained a significant, but small, predictor of severity of alcohol consequences.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Clinical and Prevention Research, Rockville, MD 20857.
U2  - PMID: 8286999.
DO  - 10.1111/j.1360-0443.1993.tb03139.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107400531
T1  - Prostate cancer screening: what we know and what we need to know.
AU  - Kramer BS
AU  - Brown ML
AU  - Prorok PC
AU  - Potosky AL
AU  - Gohagan JK
Y1  - 1993/11//11/1/93
N1  - Accession Number: 107400531. Language: English. Entry Date: 19950301. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Prostatic Neoplasms -- Prevention and Control
KW  - Cancer Screening -- Methods
KW  - Prostate-Specific Antigen
KW  - Cancer Screening -- Economics
KW  - Male
KW  - Health Care Costs
KW  - Middle Age
SP  - 914
EP  - 923
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 119
IS  - 9
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 0003-4819
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland
U2  - PMID: 7692780.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107400531&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Gaudet, Stephen J.
AU  - Slominski, Andrzej
AU  - Etminan, Mohammad
AU  - Pruski, Daniel
AU  - Paus, Ralf
AU  - Namboodiri, M. A. A.
T1  - Identification and Characterization of Two Isozymic Forms of Arylamine N-Acetyltransferase in Syrian Hamster Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/11//
VL  - 101
IS  - 5
M3  - Article
SP  - 660
EP  - 665
SN  - 0022202X
AB  - Arylamine N-acetyltransferase (EC 2.3.1.5) activity was examined using skin from Syrian hamster. Two isozymes of arylamine N-acetyltransferase, designated NAT-1 and NAT-2, were detected on anion-exchange high-performance liquid chromatography analysis. Both enzyme activities had indistinguishable molecular masses (30 kDa), but differed significantly in their specificity toward the aromatic amines including serotonin, dopamine, methoxytryptamine, tryptamine, para-phenetidine, para-aminobenzoic acid, and sulphamethazine. Specifically, NAT-2 but not NAT-1 catalyzed acetylation of dopamine to N-acetyldopamine and acetylation of serotonin to form N-acetylserotonin, a direct precursor of melatonin. The two isozymes were also distinguishable based upon their sensitivity toward methotrexate inhibition (50% inhibiting dose for NAT-1 = 380 μM; NAT-2 > 2 mM). The presence of these two activities in the skin raises new questions about the physiologic role of this enzyme in general and in the skin-specific functions in particular. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SEROTONIN
KW  - DOPAMINE
KW  - MELATONIN
KW  - ISOENZYMES
KW  - DETOXIFICATION (Alternative medicine)
KW  - HIGH performance liquid chromatography
KW  - detoxification
KW  - melatonin.
KW  - N- acetyldopamine
KW  - N-acetylserotonin
N1  - Accession Number: 12371672; Gaudet, Stephen J. 1 Slominski, Andrzej 2 Etminan, Mohammad 3 Pruski, Daniel 2 Paus, Ralf 4 Namboodiri, M. A. A. 3; Affiliation:  1: Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland.  2: Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, Albany, New York.  3: Laboratory of Molecular Neurobiology, Department of Biology, Georgetown University, Washington, D.C., U.S.A.  4: Department of Dermatology, UKRV FU Berlin, Berlin, Germany.; Source Info: Nov93, Vol. 101 Issue 5, p660; Subject Term: SEROTONIN; Subject Term: DOPAMINE; Subject Term: MELATONIN; Subject Term: ISOENZYMES; Subject Term: DETOXIFICATION (Alternative medicine); Subject Term: HIGH performance liquid chromatography; Author-Supplied Keyword: detoxification; Author-Supplied Keyword: melatonin.; Author-Supplied Keyword: N- acetyldopamine; Author-Supplied Keyword: N-acetylserotonin; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371672
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Punnonen, Kari
AU  - Denning, Mitchell
AU  - Lee, Edmund
AU  - Li, Luowei
AU  - Rhee, Sue Goo
AU  - Yuspa, Stuart H.
T1  - Keratinocyte Differentiation Is Associated with Changes in the Expression and Regulation of Phospholipase C Isoenzymes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/11//
VL  - 101
IS  - 5
M3  - Article
SP  - 719
EP  - 726
SN  - 0022202X
AB  - In murine keratinocytes, Ca++-induced terminal differentiation is accompanied by a rapid and sustained increase of inositol phosphates and diacylglycerol. Based on Western blotting analysis, basal keratinocytes cultured in 0.05 mM Ca++ medium express phospholipase C (PLC)-γ1 predominantly and no detectable PLC-β1. Differentiating keratinocytes cultured in 1.4 mM Ca++ express two- to threefold more PLC-γ1 protein and PLC-δ1, but no detectable PLC-β1. Although the amount of PLC-γ1 and -δ1 protein increased, PLC-γ1 and -δ1 mRNA decreased in differentiating cells. Thus the sustained rise of PLC activity induced by Ca++ in differentiating keratinocytes may be associated with higher amounts of both PLC-γ1 and -δ1 in maturing cells, determined by a posttranscriptional mechanism. Tyrosine phosphate content in PLC-γ1 was low in basal cells and did not change in cells exposed to 1.4 mM Ca++. However, genistein inhibited the increase in PLC activity induced by 1.4 mM Ca++. In contrast, transforming growth factor (TGF)α, which stimulates both PLC activity and growth in basal keratinocytes, increased tyrosine phosphorylation of PLC-γ1. These results suggest that tyrosine phosphorylation of PLC-γ1 by the epidermal growth factor (EGF) receptor is linked to stimulated proliferation, whereas stimulation of PLC activity by Ca++ is linked to keratinocyte differentiation and involves the action of a tyrosine kinase but not tyrosine phosphorylation of PLC-γ1. Based on studies using the intracellular free Ca++ chelator BAPTA, a rise in intracellular free Ca++ was not required for stimulation of PLC activity by raising extracellular Ca++. Phorbol esters inhibited PLC stimulation by 1.4 mM Ca++ medium and increased serine phosphorylation of PLC-γ1. Exogenous phosphatidy... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALCIUM
KW  - PHOSPHORYLATION
KW  - TYROSINE
KW  - PROTEIN kinase C
KW  - KERATINOCYTES
KW  - INOSITOL phosphates
KW  - BAPTA
KW  - calcium
KW  - protein kinase C.
KW  - tyrosine phosphorylation
N1  - Accession Number: 12371682; Punnonen, Kari 1 Denning, Mitchell 1 Lee, Edmund 1 Li, Luowei 1 Rhee, Sue Goo 2 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Laboratory of Biochemistry, National Heart, Lung and Blood Institute, Bethesda, Maryland, U.S.A.; Source Info: Nov93, Vol. 101 Issue 5, p719; Subject Term: CALCIUM; Subject Term: PHOSPHORYLATION; Subject Term: TYROSINE; Subject Term: PROTEIN kinase C; Subject Term: KERATINOCYTES; Subject Term: INOSITOL phosphates; Author-Supplied Keyword: BAPTA; Author-Supplied Keyword: calcium; Author-Supplied Keyword: protein kinase C.; Author-Supplied Keyword: tyrosine phosphorylation; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371682
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Waters, Haywood L.
AU  - Seetharam, Saraswathy
AU  - Seidman, Michael M.
AU  - Kraemer, Kenneth H.
T1  - Ultraviolet Hypermutablity of a Shuttle Vector Propagated in Xeroderma Pigmentosum Variant Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/11//
VL  - 101
IS  - 5
M3  - Article
SP  - 744
EP  - 748
SN  - 0022202X
AB  - Patients with the variant form of xeroderma pigmentosum (XP) have clinical XP including a high frequency of skin cancer but, in contrast to the other forms of XP, have normal post-ultraviolet (UV) DNA excision repair and nearly normal post-UV survival. However, like excision repair-deficient XP cells, the XP variant cells are UV hypermutable. We used a UV-treated plasmid shuttle vector, pZ189, to examine the DNA repair defect in lymphoblastoid cells from an XP variant patient, XPPHBE, and a normal control. Plasmid repair, mutagenesis, and replication occur within transfected cells in a process dependent on the cells' repair capacity. With the XP variant cells post-UV, plasmid survival was normal with but there was an abnormally increased post-UV plasmid mutation frequency. Sequence analysis of the mutated plasmids revealed an increased frequency of plasmids with single base substitution mutations with the XP variant cells. As in earlier studies with UV mutagenesis, there was a predominance of G:C→A:T base substitution mutations with plasmids recovered from both cell lines. The frequency of G:C→C:G transversions was significantly higher with plasmids recovered from the XP variant cells than from normal cells. The location of mutations in the marker gene was non-random with different mutagenic hotspots found in plasmids recovered from the XP variant cells and from the normal cells. This study suggests that plasmid UV hypermutability in the presence of normal UV survival may be related to the increased UV skin cancer susceptibility of XP variant patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA repair
KW  - TUMORS
KW  - LYMPHOBLASTOID cell lines
KW  - MUTAGENESIS
KW  - DNA
KW  - RNA
KW  - <em>F</em> tRNA
KW  - lymphoblastoid cells.
KW  - skin cancer
N1  - Accession Number: 12371686; Waters, Haywood L. 1 Seetharam, Saraswathy 1 Seidman, Michael M. 2 Kraemer, Kenneth H. 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Otsuka Pharmaceuticals, Rockville, Maryland, U.S.A.; Source Info: Nov93, Vol. 101 Issue 5, p744; Subject Term: DNA repair; Subject Term: TUMORS; Subject Term: LYMPHOBLASTOID cell lines; Subject Term: MUTAGENESIS; Subject Term: DNA; Subject Term: RNA; Author-Supplied Keyword: <em>F</em> tRNA; Author-Supplied Keyword: lymphoblastoid cells.; Author-Supplied Keyword: skin cancer; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371686
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - Fatherhood in America: A History/Fathers and Families: Paternal Factors in Child Development (Book).
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1993/11//
VL  - 55
IS  - 4
M3  - Book Review
SP  - 1047
EP  - 1049
SN  - 00222445
AB  - Reviews the books "Fatherhood in America: A History," by Robert L. Griswold; and "Fathers and Families: Paternal Factors in Child Development," by Henry B. Biller.
KW  - NONFICTION
KW  - GRISWOLD, Robert L.
KW  - BILLER, Henry B.
KW  - FATHERHOOD in America: A History (Book)
KW  - FATHERS & Families: Paternal Factors in Child Development (Book)
N1  - Accession Number: 9411174307; Lamb, Michael E. 1; Affiliation:  1: National Institute of Child Health and Human Development.; Source Info: Nov93, Vol. 55 Issue 4, p1047; Subject Term: NONFICTION; Reviews & Products: FATHERHOOD in America: A History (Book); Reviews & Products: FATHERS & Families: Paternal Factors in Child Development (Book); People: GRISWOLD, Robert L.; People: BILLER, Henry B.; Number of Pages: 3p; Document Type: Book Review; Full Text Word Count: 1920
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104785631
T1  - Pontine and extrapontine myelinolysis: a neurologic disorder following rapid correction of hyponatremia.
AU  - Karp, B I
AU  - Laureno, R
Y1  - 1993/11//1993 Nov
N1  - Accession Number: 104785631. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Hyponatremia -- Therapy
KW  - Brain Diseases, Metabolic -- Etiology
KW  - Adult
KW  - Aged
KW  - Brain -- Pathology
KW  - Female
KW  - Human
KW  - Hyponatremia -- Complications
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Age
KW  - Brain Diseases, Metabolic -- Diagnosis
KW  - Retrospective Design
SP  - 359
EP  - 373
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 72
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Neurologic disorders developing after correction of severe, symptomatic hyponatremia were studied in 14 patients. None had a hypoxic event or other identifiable cause for the neurologic illness. Neurologic deterioration began about 3 days after correction and often followed a period of improvement in hyponatremic encephalopathy. Although the symptoms were as mild as transient confusion in 1 patient, they were more severe in the others. Typically, spastic quadriparesis, pseudobulbar palsy, and impairment in the level of consciousness progressed for up to 7 days. Improvement generally began 2 weeks after correction and continued for up to a year in some patients. Routine spinal fluid analysis was usually normal, but myelin basic protein concentration was elevated in all patients in whom it was measured. Electroencephalograms commonly showed nonfocal slowing. Brainstem auditory evoked potential latencies were prolonged in some patients. Brain imaging was normal in the initial week of illness, while later scans, obtained in 9 patients, showed central pontine and/or symmetric extrapontine lesions. The clinical manifestations and distribution of lesions seen on imaging demonstrate that neurologic illness following correction of hyponatremia is due to myelinolysis. Although this neurologic disorder typically followed an elevation in serum sodium > 18 mEq/L/24 hr, it sometimes followed a rise as slow as 10 mEq/L/24 hr and 21 mEq/L/48 hr. Whenever possible, the rate of correction of hyponatremia should be kept below these values in order to minimize the risk of myelinolysis.
SN  - 0025-7974
AD  - National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 8231786.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Pavitt, Graham D.
AU  - Higgins, Christopher F.
T1  - Chromosomal domains of supercoiling in Salmonella typhimurium.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/11//
VL  - 10
IS  - 3
M3  - Article
SP  - 685
EP  - 696
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The chromosomes of enteric bacteria are divided into about 50 independently supercoiled domains. It is not known whether the net level of DNA supercoiling is similar in each domain, or whether the domains are differentially supercoiled. We have addressed this question genetically, using a supercoiling-sensitive promoter to probe the relative levels of supercoiling at defined points around the <em>Salmonella typhimurium</em> chromosome. We conclude that, within the limits of resolution of this approach, the level of supercoiling does not differ significantly between chromosomal domains, and that each domain responds in a similar fashion to factors that perturb supercoiling. These findings have implications for the organization of the bacterial genome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Enterobacteriaceae
KW  - Bacteria
KW  - Chromosomes
KW  - DNA
KW  - Genes
KW  - Genetic recombination
KW  - Salmonella typhimurium
N1  - Accession Number: 16582824; Pavitt, Graham D. 1,2; Higgins, Christopher F. 1; Affiliations: 1: Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK; 2: National Institute of Child Health and Human Development, Building 6B, Room 3B-309, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Nov1993, Vol. 10 Issue 3, p685; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Bacteria; Subject Term: Chromosomes; Subject Term: DNA; Subject Term: Genes; Subject Term: Genetic recombination; Subject Term: Salmonella typhimurium; Number of Pages: 12p; Illustrations: 2 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Pivik, R. T.
AU  - Broughton, R. J.
AU  - Coppola, R.
AU  - Davidson, R. J.
AU  - Fox, N.
AU  - Nuwer, M. R.
T1  - Guidelines for the recording and quantitative analysis of electroencephalographic activity in research contexts.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1993/11//
VL  - 30
IS  - 6
M3  - Article
SP  - 547
EP  - 558
SN  - 00485772
AB  - Developments in technologic and analytical procedures applied to the study of brain electrical activity have intensified interest in this modality as a means of examining brain function. The impact of these new developments on traditional methods of acquiring and analyzing electroencephalographic activity requires evaluation. Ultimately, the integration of the old with the new must result in an accepted standardized methodology to be used in these investigations. In this paper, basic procedures and recent developments involved in the recording and analysis of brain electrical activity are discussed and recommendations are made, with emphasis on psychophysiological applications of these procedures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BRAIN
KW  - METHODOLOGY
KW  - TECHNOLOGY
KW  - PSYCHOPHYSIOLOGY
KW  - ELECTROENCEPHALOGRAPHY
KW  - SLEEP
KW  - PEDIATRICS
KW  - STATISTICS
KW  - Artifacts
KW  - EEG recordings
KW  - Pediatrics
KW  - Quantified EEG
KW  - Sleep
KW  - Statistical analyses.
KW  - BERGER, Hans
N1  - Accession Number: 11185168; Pivik, R. T. 1 Broughton, R. J. 2 Coppola, R. 3 Davidson, R. J. 4 Fox, N. 5 Nuwer, M. R. 6; Affiliation:  1: Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada.  2: Department of Medicine (Neurology), University of Ottawa, Ottawa, Ontario, Canada.  3: National Institute of Mental Health, Washington, DC.  4: Department of Psychology, University of Wisconsin-Madison.  5: Department of Human Development, University of Maryland-College Park.  6: Department of Neurology, University of California-Los Angeles.; Source Info: Nov1993, Vol. 30 Issue 6, p547; Subject Term: BRAIN; Subject Term: METHODOLOGY; Subject Term: TECHNOLOGY; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: ELECTROENCEPHALOGRAPHY; Subject Term: SLEEP; Subject Term: PEDIATRICS; Subject Term: STATISTICS; Author-Supplied Keyword: Artifacts; Author-Supplied Keyword: EEG recordings; Author-Supplied Keyword: Pediatrics; Author-Supplied Keyword: Quantified EEG; Author-Supplied Keyword: Sleep; Author-Supplied Keyword: Statistical analyses.; People: BERGER, Hans; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1469-8986.ep11185168
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zahn, Theodore P.
AU  - Kruesi, Markus J. P.
T1  - Autonomic activity in boys with disruptive behavior disorders.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1993/11//
VL  - 30
IS  - 6
M3  - Article
SP  - 605
EP  - 614
SN  - 00485772
AB  - Skin conductance (SC) and heart rate (HR) were measured during rest, a series of tones, and a reaction time task in 34 boys with disruptive behavior disorder to ascertain (a) if this broadly defined group differed from control boys (n = 33) and (b) if there were differences within the spectrum related to component diagnoses or to target behaviors. Disruptive boys had higher resting HR than controls, due largely to those without a subdiagnosis of conduct disorder. Disruptive boys showed a smaller increment in SC response frequency for task instructions. They did not show a general deficit in phasic SC reactivity but habituated to signal stimuli at a faster rate than did controls. However, their SC response latencies were shorter despite slower motor reaction time. Responsivity variables were similar in boys with and without a subdiagnosis of conduct disorder. The data are not compatible with the hypothesis of low autonomic nervous system (ANS) baselines in disruptive boys but partially suggest low ANS reactivity. They generally support the validity of the disruptive behavior disorder spectrum. Correlations with measures of aggression and impulsivity suggest that individual differences within the spectrum might be more fruitfully described by behavior dimensions than by conventional subdiagnoses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEART beat
KW  - SKIN
KW  - BEHAVIOR disorders in children
KW  - GALVANIC skin response
KW  - ATTENTION-deficit hyperactivity disorder
KW  - CONDUCT disorders in children
KW  - CORRELATION (Statistics)
KW  - BOYS
KW  - Aggression.
KW  - Attention-deficit hyperactivity disorder
KW  - Conduct disorder
KW  - Disruptive behavior disorders
KW  - Electrodermal activity
KW  - Heart rate
N1  - Accession Number: 11185204; Zahn, Theodore P. 1 Kruesi, Markus J. P. 2; Affiliation:  1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD.  2: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD.; Source Info: Nov1993, Vol. 30 Issue 6, p605; Subject Term: HEART beat; Subject Term: SKIN; Subject Term: BEHAVIOR disorders in children; Subject Term: GALVANIC skin response; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: CONDUCT disorders in children; Subject Term: CORRELATION (Statistics); Subject Term: BOYS; Author-Supplied Keyword: Aggression.; Author-Supplied Keyword: Attention-deficit hyperactivity disorder; Author-Supplied Keyword: Conduct disorder; Author-Supplied Keyword: Disruptive behavior disorders; Author-Supplied Keyword: Electrodermal activity; Author-Supplied Keyword: Heart rate; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1469-8986.ep11185204
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11185204&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2008-13502-013
AN  - 2008-13502-013
AU  - Corwin, R. L.
AU  - Robinson, J. K.
AU  - Crawley, J. N.
T1  - Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1993/11//
VL  - 5
IS  - 11
SP  - 1528
EP  - 1533
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Corwin, R. L., Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4N214, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13502-013. PMID: 7506975 Partial author list: First Author & Affiliation: Corwin, R. L.; Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20081020. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amygdala; Animal Feeding Behavior; Food Intake; Hypothalamus; Neuropeptides. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 1993. 
AB  - Galanin significantly increased food intake when microinjected into the region of the central nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In the amygdala this effect was specific to feeding; no change in grooming, resting, or other behaviour was observed after galanin treatment. These results provide evidence that the amygdala may be an important site in the mediation of galanin-induced feeding. The galanin receptor antagonists, C7 and M40, antagonized galanin-induced feeding, while having no effect alone on food consumption in free-feeding rats. These new galanin receptor antagonists provide useful tools for further investigating the role of endogenous galanin in the regulation of feeding. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - galanin antagonists
KW  - galanin-induced feeding
KW  - hypothalamus
KW  - amygdala
KW  - rats
KW  - food intake
KW  - 1993
KW  - Amygdala
KW  - Animal Feeding Behavior
KW  - Food Intake
KW  - Hypothalamus
KW  - Neuropeptides
KW  - Rats
KW  - 1993
DO  - 10.1111/j.1460-9568.1993.tb00221.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13502-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105714900
T1  - Classic nephropathic cystinosis as an adult disease.
AU  - Theodoropoulos DS
AU  - Krasnewich D
AU  - Kaiser-Kupfer MI
AU  - Gahl WA
AU  - Theodoropoulos, D S
AU  - Krasnewich, D
AU  - Kaiser-Kupfer, M I
AU  - Gahl, W A
Y1  - 1993/11/10/
N1  - Accession Number: 105714900. Language: English. Entry Date: 20081212. Revision Date: 20161112. Publication Type: journal article; research. Commentary: Andrews P A, Sacks S H, van't Hoff W. Successful pregnancy in cystinosis. (JAMA) 11/2/94; 272 (17): 1327-1328. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Kidney Transplantation
KW  - Metabolism, Inborn Errors -- Physiopathology
KW  - Metabolism, Inborn Errors -- Surgery
KW  - Adult
KW  - Amines -- Therapeutic Use
KW  - Central Nervous System Diseases -- Etiology
KW  - Economic Aspects of Illness
KW  - Endocrine Diseases -- Etiology
KW  - Female
KW  - Graft Survival
KW  - Growth
KW  - Male
KW  - Metabolism, Inborn Errors -- Complications
KW  - Metabolism, Inborn Errors -- Therapy
KW  - Muscular Diseases -- Etiology
KW  - Prospective Studies
KW  - Survival Analysis
KW  - Visual Acuity
KW  - Human
SP  - 2200
EP  - 2204
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 270
IS  - 18
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To delineate the clinical characteristics of infantile nephropathic cystinosis in adult patients who have undergone renal transplantation.Design: Case series.Setting: Clinical research unit.Patients: All 36 adult patients with nephropathic cystinosis referred to the National Institutes of Health.Outcome Measures: Longevity, growth, renal allograft survival, visual acuity, endocrine insufficiency, myopathy and swallowing dysfunction, cerebral calcifications, and occupational status.Results: Of the 36 patients, seven were dead, five with functioning allografts. The 1-year and 5-year graft survival rates for 30 cadaveric allografts were 90% and 75%, respectively. The patients' mean height and weight were severely retarded. Five patients were legally blind, and three others had severely impaired vision in one eye. Thirty-one (86%) of 36 patients required thyroid hormone replacement therapy. One third had a distal myopathy, and 21 had moderate to severe swallowing abnormalities. Eight patients had cerebral calcifications on computed tomographic scan. Despite these complications, the sighted patients engaged in a normal variety of occupations. Only 11 patients were receiving adequate cystine-depleting therapy with cysteamine (mercaptamine) or phosphocysteamine.Conclusions: Adult patients with nephropathic cystinosis suffer serious complications of the disease.
SN  - 0098-7484
AD  - Interinstitute Medical Genetics Program, National Institutes of Health Clinical Center, Bethesda, MD 20892
AD  - Interinstitute Medical Genetics Program, National Institutes of Health Clinical Center, Bethesda, MD 20892.
U2  - PMID: 8411603.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105714900&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105851175
T1  - Mortality by Hispanic status in the United States.
AU  - Sorlie PD
AU  - Backlund E
AU  - Johnson NJ
AU  - Rogot E
AU  - Sorlie, P D
AU  - Backlund, E
AU  - Johnson, N J
AU  - Rogot, E
Y1  - 1993/11/24/
N1  - Accession Number: 105851175. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article; research. Commentary: Pablos-Méndez A. Mortality among Hispanics. (JAMA) 4/27/94; 271 (16): 1237-1237. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Hispanics -- Statistics and Numerical Data
KW  - Mortality -- Trends
KW  - Adult
KW  - Aged
KW  - Cause of Death
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Population
KW  - Prospective Studies
KW  - Socioeconomic Factors
KW  - United States
KW  - Human
SP  - 2464
EP  - 2468
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 270
IS  - 20
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To compare all-cause and cause-specific mortality rates between Hispanic and non-Hispanic groups and estimate the effect of family income, place of birth, and place of residence on these rates.Design: Cohort study using national survey data matched to the National Death Index, with a mortality follow-up period of 9 years.Setting: The noninstitutionalized population of the United States.Participants: Approximately 700,000 respondents (aged 25 years or older), including 40,000 Hispanics, to national surveys conducted by the US Bureau of the Census (Current Population Surveys).Outcome Measures: All causes and underlying cause of death, coded from the death certificate, occurring between 1979 and 1987.Results: Adjusting for age, Hispanics were shown to have lower mortality from all causes compared with non-Hispanics (standardized rate ratio [SRR], 0.74 for men, 0.82 for women), lower mortality from cancer (SRR, 0.69 for men, 0.61 for women), lower mortality from cardiovascular disease (SRR, 0.65 for men, 0.80 for women), higher mortality from diabetes (SRR, 1.86 for men, 2.38 for women), and higher mortality from homicide (SRR, 3.60 for men). After adjusting for differences in annual family income, the relative mortality ratios were even lower for Hispanics than non-Hispanics.Conclusions: These data describe, in a large national cohort study, a lower mortality in Hispanics than in non-Hispanics. This mortality is particularly low after adjustment for differences in family income.
SN  - 0098-7484
AD  - Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
AD  - Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 8031341.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105851175&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104784691
T1  - Comparison of DSM-III-R and draft DSM-IV alcohol abuse and dependence in a general population sample.
AU  - Grant, B F
Y1  - 1993/12//
N1  - Accession Number: 104784691. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcoholism -- Diagnosis
KW  - Psychological Tests
KW  - Substance Use Disorders -- Diagnosis
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Alcoholism -- Epidemiology
KW  - Population
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Prevalence
KW  - Sex Factors
KW  - Substance Use Disorders -- Epidemiology
KW  - United States
SP  - 1709
EP  - 1716
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 88
IS  - 12
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - The purpose of this Data Note was to compare DSM-III-R and Draft DSM-IV formulations of alcohol use disorders in terms of prevalence and overlap in a representative sample of the United States general population. The prevalence of DSM-III-R and DSM-IV alcohol abuse and dependence combined were strikingly similar, despite discrepancies in the separate component diagnoses of abuse and dependence. The major finding of this study showed a reversal of the abuse-to-dependence ratio associated with the DSM-IV classification. Unlike previous surveys using DSM-III-R definitions, the prevalence of DSM-IV abuse exceeded that of dependence in this general population sample. Reasons for this discrepancy were discussed in terms of the differences in the number and content of abuse and dependence criteria and the relationship between abuse and dependence categories. The need for an explicit statement justifying the changes in the DSM-IV classification is highlighted.
SN  - 0965-2140
AD  - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20857.
U2  - PMID: 8130711.
DO  - 10.1111/j.1360-0443.1993.tb02047.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104784691&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Salive, Marcel E.
AU  - Collins, Karen S.
AU  - Foley, Daniel J.
AU  - George, Linda K.
T1  - Predictors of Nursing Home Admission in a Biracial Population.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1993/12//
VL  - 83
IS  - 12
M3  - Article
SP  - 1765
EP  - 1767
PB  - American Public Health Association
SN  - 00900036
AB  - Racial differences in predictors of institutionalization were studied in a biracial North Carolina cohort (n = 4074). During 3 years of follow-up, 8.5% of Whites and 6.4% of African Americans were admitted to nursing homes. African Americans were one half as likely as Whites to be institutionalized after adjustment for other risk factors. Among Whites, impaired activities of daily living and cognition were the strongest predictors; among African Americans, impaired instrumental activities of daily living and prior history of nursing home use were strongest. Racial differences in nursing home use were not explained by financial and social support or physical and cognitive impairment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RACIAL differences
KW  - WHITES
KW  - AFRICAN Americans
KW  - NURSING care facilities
KW  - NORTH Carolina
N1  - Accession Number: 9405270148; Salive, Marcel E. 1 Collins, Karen S. 1,2 Foley, Daniel J. 1 George, Linda K. 3; Affiliation:  1: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Md.  2: General Preventive Medicine Residency Program, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md.  3: Center for the Study of Aging and Human Development, Duke University, Durham, NC; Source Info: Dec1993, Vol. 83 Issue 12, p1765; Subject Term: RACIAL differences; Subject Term: WHITES; Subject Term: AFRICAN Americans; Subject Term: NURSING care facilities; Subject Term: NORTH Carolina; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gross, J. A.;
AU  - Pucino, F.;
AU  - Amantea, M.;
AU  - Rodgers, G.;
AU  - Gracely, R.;
AU  - Williams, L.;
AU  - Chicca, L.;
AU  - Max, M.;
AU  - Hoffman, M.;
AU  - Gallelli, J. F.;
T1  - Pharmacokinetics and pharmacodynamics of morphine in patients with sickle cell anemia (SCA)
CT  - Pharmacokinetics and pharmacodynamics of morphine in patients with sickle cell anemia (SCA)
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1993/12/01/
VL  - 28
IS  - Dec
SP  - P
EP  - )
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Department of Pharmacy, Building 10 Room 1 N 257, Bethesda, MD 20814, USA
N1  - Accession Number: 30-14066; Language: English; Chemical Name: Morphine--57-27-2; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Pharmacology
N2  - The pharmacokinetics and pharmacodynamics of oral and intravenous morphine in SCA patients will be evaluated in a randomized, cross-over, controlled study. Twelve stable adult patients with SCA and twelve matched (age, race, and sex) normal volunteers will be administered oral (30 mg sustained-release) and intravenous (10 mg) morphine, with a seven day wash-out period between treatments. Serum concentrations of morphine and its primary metabolites will be determined for pharmacokinetics analysis. Patient sensitivity to experimental pain (thermal stimuli) will be assessed before and after oral morphine. Pharmacokinetics and pharmacodynamics data will be co-modeled, and group comparisons analyzed statistically.
KW  - Morphine--dosage forms-;
KW  - Practice Interest Areas--Clinical Pharmacokinetics--meeting presentations;
KW  - ASHP meeting abstracts--morphine dosage forms, pharmacokinetics;
KW  - Pharmacokinetics--morphine--dosage forms, sickle cell anemia;
KW  - Pharmacodynamics--morphine--dosage forms, sickle cell anemia;
KW  - Dosage forms--morphine--dosage forms, pharmacokinetics, sickle cell anemia;
KW  - Anemia--morphine--sickle cell, dosage forms, pharmacokinetics;
KW  - Sustained-action medications--morphine--vs IV, pharmacokinetics, sickle cell anemia;
KW  - Injections--morphine--vs oral, pharmacokinetics, sickle cell anemia;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-14066&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Green, L.;
T1  - Ethical, legal and social considerations
CT  - Ethical, legal and social considerations
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1993/12/01/
VL  - 28
IS  - Dec
SP  - PI
EP  - 44
AD  - National Institutes of Health Clinical Center, Pharmacy Department, Bldg. 10, Room, 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 30-14137; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics; Legislation, Laws and Regulations
N2  - Mapping the human genome will increase our ability to predict, understand, and eventually prevent or cure human diseases. The National Institutes of Health support activities that focus on anticipating issues arising from the application of the results of the Human Genome Project and on proposing solutions that will forestall adverse effects. This presentation will focus on the numerous social, legal, and ethical implications of this endeavor. The basic issues involve fairness in the use of genetic information. There is also the question of the impact of genetic information on the individual. Privacy and confidentiality of genetic information is currently a topic of controversy.
KW  - ASHP meeting abstracts--gene therapy, ethics;
KW  - Ethics--Human Genome Project;
KW  - Legislation--Human Genome Project;
KW  - Sociology--Human Genome Project;
KW  - Human Genome Project--research--ethics, legislation, sociology;
KW  - Gene therapy--Human Genome Project--ethics, sociology, legislation;
KW  - Research--Human Genome Project--ethics, sociology, legislation;
KW  - Genetics--Human Genome Project--issues;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-14137&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Green, L.;
T1  - Perspectives on human gene therapy
CT  - Perspectives on human gene therapy
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1993/12/01/
VL  - 28
IS  - Dec
SP  - PI
EP  - 30
AD  - National Institutes of Health, Clinical Center Pharmacy Department, Bldg. 10, Rm. 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 30-14035; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Institutional Pharmacy Practice
N2  - Gene therapy is a technique in which a functioning gene is inserted into a human cell to correct a genetic error or to introduce a new function to the cell. This presentation will focus on the possibilities of gene therapy in clinical practice. A variety of goals exist for the new breed of gene therapists, and new possibilities are almost continuously envisioned. We are at the very beginning of an exciting new era that has the potential to revolutionize the therapy of a number of human disorders. Many additional interesting opportunities will likely develop as the Human Genome Initiative progresses and new genes are identified.
KW  - ASHP meeting abstracts--gene therapy;
KW  - Gene therapy--research;
KW  - Research--gene therapy;
KW  - Genetics--research--gene therapy;
KW  - Clinical pharmacy--gene therapy--research;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-14035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Minor, J. R.;
T1  - Status of HIV vaccine development
CT  - Status of HIV vaccine development
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1993/12/01/
VL  - 28
IS  - Dec
SP  - PI
EP  - -7
AD  - United States Public Health Service National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 30-14046; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2  - In conjunction with the on-going evaluation, development, and application of antiretroviral agents, high priority is being placed on the development of a safe and effective AIDS vaccine. Although no optimal vaccine candidate has yet emerged for large-scale efficacy trials, tremendous progress has been made toward this goal, and it is predicted that such trials will begin within the next few years.
KW  - Acquired immunodeficiency syndrome vaccines--immunization-;
KW  - ASHP meeting abstracts--acquired immunodeficiency syndrome vaccines;
KW  - Acquired immunodeficiency syndrome--immunization--vaccines, research;
KW  - Immunization--acquired immunodeficiency syndrome--vaccines, research;
KW  - Research--acquired immunodeficiency syndrome vaccines--immunization;
KW  - Vaccines--acquired immunodeficiency syndrome--immunization;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-14046&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Green, L.;
T1  - Update on human gene therapy
CT  - Update on human gene therapy
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1993/12/01/
VL  - 28
IS  - Dec
SP  - PI
EP  - 45
AD  - National Institutes of Health Clinical Center, Pharmacy Department, Bldg. 10, Room 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 30-14049; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2  - Gene therapy is a technique in which a functioning gene is inserted into a human cell to correct a genetic error or to introduce a new function to the cell. This presentation will focus on the latest applications of this technique to clinical practice. There are over 50 gene therapy clinical trials approved involving such diseases as SCID, cancer, cystic fibrosis, and hypercholesterolemia. Preliminary data are now available that give optimism for this new approach to treat patients. As the human genome is deciphered and more pathologic genes are identified, gene therapy trials will expand.
KW  - ASHP meeting abstracts--gene therapy;
KW  - Research--gene therapy--clinical studies;
KW  - Gene therapy--research--clinical studies;
KW  - Clinical studies--gene therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-14049&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Grothe, D. R.;
AU  - Kinney-Parker, J. L.;
AU  - Mandoki, M. W.;
T1  - Pediatric psychiatry and treatment: therapeutic controversies and case discussion
CT  - Pediatric psychiatry and treatment: therapeutic controversies and case discussion
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1993/12/01/
VL  - 28
IS  - Dec
SP  - SPG
EP  - ,39
AD  - National Institutes of Health Clinical Center Pharmacy Department, 9000 Rockville Pike, Building 10, Room 1N-257, Bethesda, MD 20814, USA
N1  - Accession Number: 30-14034; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - This presentation shall focus on therapeutic dilemmas in the child-adolescent psychiatric patient population. Since psychotropic medications are not well studied in this population, choice of drug(s) is controversial. Clinical psychiatric pharmacists and child psychiatrists will discuss and debate the use of psychotropic medications in childhood mental health disorders such as ADHD, Tourette's, depression, aggression, PTSD, PDD, OCD, and Childhood Psychosis through the use of case studies. A symptomatic approach to drug treatment will be taken. Symptoms which seem to have little response to drug treatment will also be discussed. The scientific rationale for use of specific drugs will be explained.
KW  - ASHP meeting abstracts--psychotherapeutic agents, pediatrics;
KW  - Psychotherapeutic agents--psychotic agents--therapy, pediatrics;
KW  - Psychotic disorders--psychotherapeutic agents--pediatrics;
KW  - Pediatrics--psychotherapeutic agents--psychotic disorders therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-14034&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lastoria, S.
AU  - Maurea, S.
AU  - Caracò, C.
AU  - Vergara, E.
AU  - Maurelli, L.
AU  - Indolfi, P.
AU  - Casale, F.
AU  - Tullio, M.
AU  - Salvatore, M.
T1  - Iodine-131 metaiodobenzylguanidine scintigraphy for localization of lesions in children with neuroblastoma: comparison with computed tomography and ultrasonography.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1993/12//
VL  - 20
IS  - 12
M3  - Article
SP  - 1161
EP  - 1167
SN  - 03406997
N1  - Accession Number: 71146095; Lastoria, S. 1 Maurea, S. 1 Caracò, C. 1 Vergara, E. 1 Maurelli, L. 1 Indolfi, P. 2 Casale, F. 2 Tullio, M. 2 Salvatore, M. 1; Affiliation:  1: Department of Nuclear Medicine, National Cancer Institute and University Federico II, Napoli Italy  2: Department of Pediatric Oncology, 1st University, Napoli Italy; Source Info: Dec1993, Vol. 20 Issue 12, p1161; Number of Pages: 7p; Document Type: Article
L3  - 10.1007/BF00171014
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=71146095&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cuocolo, Alberto
AU  - Maurea, Simone
AU  - Pace, Leonardo
AU  - Nicolai, Emanuele
AU  - Nappi, Antonio
AU  - Imbriaco, Massimo
AU  - Trimarco, Bruno
AU  - Salvatore, Marco
T1  - Resting technetium-99m methoxyisobutylisonitrile cardiac imaging in chronic coronary artery disease: comparison with rest-redistribution thallium-201 scintigraphy.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1993/12//
VL  - 20
IS  - 12
M3  - Article
SP  - 1186
EP  - 1192
SN  - 03406997
N1  - Accession Number: 71146092; Cuocolo, Alberto 1 Maurea, Simone 1 Pace, Leonardo 1 Nicolai, Emanuele 1 Nappi, Antonio 1 Imbriaco, Massimo 1 Trimarco, Bruno 2 Salvatore, Marco 3; Affiliation:  1: Department of Nuclear Medicine, University Federico II, Napoli Italy  2: Department of Internal Medicine, University Federico II, Napoli Italy  3: National Cancer Institute, Napoli Italy; Source Info: Dec1993, Vol. 20 Issue 12, p1186; Number of Pages: 7p; Document Type: Article
L3  - 10.1007/BF00171017
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=71146092&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105850800
T1  - Training researchers in cancer prevention and control: a description and evaluation of NCI's Cancer Prevention Fellowship Program.
AU  - Husten CG
AU  - Weed DL
AU  - Kaluzny AD
Y1  - 1993///1993 Winter
N1  - Accession Number: 105850800. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 8610343. 
KW  - National Institutes of Health (U.S.)
KW  - Neoplasms -- Prevention and Control
KW  - Oncology -- Education
KW  - Research -- Education
KW  - Training Support, Financial
KW  - Attitude of Health Personnel
KW  - Career Planning and Development
KW  - Curriculum
KW  - Demography
KW  - Education, Medical
KW  - Female
KW  - Goals and Objectives
KW  - Male
KW  - Preceptorship
KW  - Program Development
KW  - Program Evaluation
KW  - Public Health Administration -- Education
KW  - Teaching
KW  - United States
SP  - 281
EP  - 290
JO  - Journal of Cancer Education
JF  - Journal of Cancer Education
JA  - J CANCER EDUC
VL  - 8
IS  - 4
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - NCI's Cancer Prevention Fellowship Program recently initiated a continuing evaluation of the fellows' demographics, fellows' accomplishments in the program, fellow and preceptor expectations and satisfaction, program strengths and weaknesses, current employment for former fellows, and ex-fellows' perceptions of program training. Evaluation shows that the program attracts quality applicants (including minorities and females) nationwide from many disciplines. The program successfully educates about cancer prevention and provides a positive preceptor experience with publication opportunities. Areas for improvement are data access, stipend, office space, job assistance, and networking. Recommendations for other programs include committed enthusiastic staff; adequate budget, space, and support; a formal learning experience in public health fundamentals, research methods, and cancer prevention; individual mentored research within a productive scientific program; aggressive recruitment; competitive admissions policy; defined objectives for fellows; and ongoing formal program evaluation.
SN  - 0885-8195
AD  - National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, MD 20892.
U2  - PMID: 8186080.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850800&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - Biological Determinism Redux: Comment on Silverstein (1993).
JO  - Journal of Family Psychology
JF  - Journal of Family Psychology
Y1  - 1993/12//
VL  - 7
IS  - 3
M3  - Article
SP  - 301
EP  - 304
SN  - 08933200
AB  - L. B. Silverstein (1993) criticizes some sociobiologists and psychologists for inferences that are not consistent with the more recent scholarship. In this commentary, it is shown that sociobiology is widely misunderstood. Contrary to popular belief, sociobiologists are not determinists. Instead, most sociobiologists emphasize the important role of environmental factors in shaping the manifestations of endogenous tendencies (not imperatives). In addition, the empirical evidence (e.g., Lamb & Goldberg, 1992) fails to support the deterministic view that male primates are predestined to be uninvolved in child care. Even when correctly represented, however, it does not appear that sociobiology can play a useful role in directing public policy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIOBIOLOGY
KW  - SOCIOLOGISTS
KW  - FAMILIES -- Psychological aspects
KW  - CHILD care
KW  - CHILD rearing
KW  - FATHERS
KW  - PARENT & child
KW  - PARENTING
KW  - PARENTHOOD
N1  - Accession Number: 24570711; Lamb, Michael E. 1; Affiliation:  1: National Institute of Child Health and Human Development, Section on Social and Emotional Development, BSA Building, Room 331, 9190 Rockville Pike, Bethesda, Maryland 20814; Source Info: Dec93, Vol. 7 Issue 3, p301; Subject Term: SOCIOBIOLOGY; Subject Term: SOCIOLOGISTS; Subject Term: FAMILIES -- Psychological aspects; Subject Term: CHILD care; Subject Term: CHILD rearing; Subject Term: FATHERS; Subject Term: PARENT & child; Subject Term: PARENTING; Subject Term: PARENTHOOD; Number of Pages: 4p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24570711&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lee, Min Geol
AU  - Borkowski, Teresa A.
AU  - Udey, Mark C.
T1  - Regulation of Expression of B7 by Murine Langerhans Cells: A Direct Relationship Between B7 mRNA Levels and the Level of Surface Expression of B7 by Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1993/12//
VL  - 101
IS  - 6
M3  - Article
SP  - 883
EP  - 886
SN  - 0022202X
AB  - Cultured BALB/c epidermal Langerhans cells express high levels of the costimulatory molecule B7 on their surfaces relative to levels expressed on fresh Langerhans cells. Quantitation of relative amounts of B7 mRNA in fresh epidermal cells and cultured epidermal cells following amplification of mRNA signals via reverse transcriptase - polymerase chain reaction, hybridization of PCR products with radiolabeled internal oligonucleotide probes, resolution of hybrids in non-denaturing polyacrylamide gels, and detection by autoradiography revealed dramatically (approximately one thousandfold) higher levels of B7 mRNA in cultured epidermal cells (10-40% 1-A+) as compared with fresh epidermal cells (1 - 4% I-A+). Levels of B7 mRNA in cultured epidermal cells were also substantially greater than those detected in a reference B lymphoma cell line (CH-1). Analysis of 87 mRNA expression in subpopulations of cultured epidermal cells demonstrated that essentially all of the B7 mRNA was present in Langerhans cells; cells bearing I-A and CD45 antigens. Cultured keratinocytes did not contain appreciable amounts of B7 mRNA. These results are consistent with previous data regarding surface expression of 87 by cLC and also demonstrate that fLC are essentially devoid of B7 mRNA and surface protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLULAR pathology
KW  - LANGERHANS cells
KW  - CANCER cells
KW  - CELL culture
KW  - NUCLEIC acid probes
KW  - CELL surface antigens
KW  - MESSENGER RNA
KW  - TRANSGENES -- Expression
KW  - POLYACRYLAMIDE
KW  - AUTORADIOGRAPHY
KW  - accessory cells.
KW  - CD28
KW  - costimulatory molecules
KW  - CTLA-4
N1  - Accession Number: 12371712; Lee, Min Geol Borkowski, Teresa A. 1 Udey, Mark C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec93, Vol. 101 Issue 6, p883; Subject Term: CELLULAR pathology; Subject Term: LANGERHANS cells; Subject Term: CANCER cells; Subject Term: CELL culture; Subject Term: NUCLEIC acid probes; Subject Term: CELL surface antigens; Subject Term: MESSENGER RNA; Subject Term: TRANSGENES -- Expression; Subject Term: POLYACRYLAMIDE; Subject Term: AUTORADIOGRAPHY; Author-Supplied Keyword: accessory cells.; Author-Supplied Keyword: CD28; Author-Supplied Keyword: costimulatory molecules; Author-Supplied Keyword: CTLA-4; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371712
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12371712&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107393569
T1  - Depression and smoking cessation in older adults: a longitudinal study.
AU  - Salive ME
AU  - Blazer DG
Y1  - 1993/12//12/ 1/1993
N1  - Accession Number: 107393569. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: Supported in part by contract NO1-AG-1-2102 from the National Institute on Aging. NLM UID: 7503062. 
KW  - Depression -- In Old Age
KW  - Smoking Cessation -- In Old Age
KW  - Multiple Logistic Regression
KW  - Prospective Studies
KW  - Funding Source
KW  - Center for Epidemiological Studies Depression Scale
KW  - Psychological Tests
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1313
EP  - 1316
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892
U2  - PMID: 8227913.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107393569&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hinnebusch, Joe
AU  - Tilly, Kit
T1  - Linear plasmids and chromosomes in bacteria.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1993/12//
VL  - 10
IS  - 5
M3  - Article
SP  - 917
EP  - 922
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Linear plasmids and chromosomes were unknown in prokaryotes until recently but have now been found in spirochaetes, Gram-positive bacteria, and Gram-negative bacteria. Two structural types of bacterial linear DNA have been characterized. Linear plasmids of the spirochaete <em>Borrelia</em> have a covalently closed hairpin loop at each end and linear plasmids of the Gram-positive filamentous <em>Streptomyces</em> have a covalently attached protein at each end. Replicons with similar structures are more frequent in eukaryotic cells than in prokaryotes. Linear genomic structures are probably more common in bacteria than previously recognized, however, and some replicons may interconvert between circular and linear isomers. The molecular biology of these widely dispersed elements provides clues to explain the origin of linear DNA in bacteria, including evidence for genetic exchange between prokaryotes and eukaryotes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Prokaryotes
KW  - Spirochetes
KW  - Gram-positive bacteria
KW  - Gram-negative bacteria
KW  - Eukaryotic cells
KW  - Chromosomes
KW  - Plasmids
KW  - Borrelia
KW  - Genomes
N1  - Accession Number: 16574307; Hinnebusch, Joe 1; Tilly, Kit 2; Affiliations: 1: Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA; 2: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA; Issue Info: Dec1993, Vol. 10 Issue 5, p917; Thesaurus Term: Prokaryotes; Thesaurus Term: Spirochetes; Thesaurus Term: Gram-positive bacteria; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Eukaryotic cells; Subject Term: Chromosomes; Subject Term: Plasmids; Subject Term: Borrelia; Subject Term: Genomes; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16574307&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104784495
T1  - The misuse of analysis of variance to detect synergy in combination drug studies.
AU  - Caudle, R M
AU  - Williams, G M
Y1  - 1993/12//1993 Dec
N1  - Accession Number: 104784495. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Analysis of Variance
KW  - Drug Synergism
KW  - Dose-Response Relationship, Drug
KW  - Kinetics
KW  - Receptors, Drug -- Drug Effects
KW  - Study Design
SP  - 313
EP  - 317
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 55
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 8121692.
DO  - 10.1016/0304-3959(93)90006-B
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104784495&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104784504
T1  - Paraplegia following coeliac plexus block.
AU  - De Conno, F
AU  - Caraceni, A
AU  - Aldrighetti, L
AU  - Magnani, G
AU  - Ferla, G
AU  - Comi, G
AU  - Ventafridda, V
Y1  - 1993/12//1993 Dec
N1  - Accession Number: 104784504. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Neural Pathways
KW  - Nerve Block -- Adverse Effects
KW  - Paraplegia -- Etiology
KW  - Adenocarcinoma -- Complications
KW  - Aged
KW  - Ethanol
KW  - Evoked Potentials, Somatosensory
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Pain -- Etiology
KW  - Pain -- Therapy
KW  - Pancreatic Neoplasms -- Complications
KW  - Paraplegia -- Physiopathology
SP  - 383
EP  - 385
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 55
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division National Cancer Institute, Milan, Italy.
U2  - PMID: 8121700.
DO  - 10.1016/0304-3959(93)90015-H
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104784504&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2007-18562-001
AN  - 2007-18562-001
AU  - Hoagwood, Kimberly
T1  - Introduction: Methodological issues in school-based mental health services research.
JF  - School Psychology Quarterly
JO  - School Psychology Quarterly
JA  - Sch Psychol Q
Y1  - 1993///Win 1993
VL  - 8
IS  - 4
SP  - 239
EP  - 240
CY  - US
PB  - Guilford Publications
SN  - 1045-3830
SN  - 1939-1560
AD  - Hoagwood, Kimberly, National Institute of Mental Health-Services Research Branch, Parklawn Building, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2007-18562-001. Other Journal Title: Professional School Psychology. Partial author list: First Author & Affiliation: Hoagwood, Kimberly; National Institute of Mental Health-Services Research Branch, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Lawrence Erlbaum. Release Date: 20071210. Correction Date: 20091116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Service Needs; Mental Health Services; School Based Intervention; School Counseling; School Psychology. Classification: Educational/Vocational Counseling & Student Services (3580). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Win 1993. Copyright Statement: Division 16, American Psychological Association. 1993. 
AB  - New research directions on the effectiveness of mental health services for children and adolescents offer the opportunity for school psychology to apply its knowledge base to the systemic juncture between mental health and school systems. Models of service delivery to children, adolescents, and their families that integrate school, mental health, and other service sectors are being actively studied to answer questions about the outcomes of these services for children with mental health problems. The papers in this journal were first presented at the 6th Annual Research Conference of the Florida Mental Health Institute on 'A System of Care for Children's Mental Health: Expanding the Research Base.' The papers describe state-of-the art studies of school-based mental health interventions for children, adolescents, and their families. In each of the papers, particular attention is paid to the salient methodological issues researchers face in conducting these studies within school settings. It is hoped that these articles will foreground the healthy and creative tensions that exist between different research paradigms and multiple service communities, especially mental health and school systems, by encouraging new research on important and as yet unanswered questions about the effectiveness of school-based service delivery to children and adolescents with mental health needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mental health needs
KW  - school-based mental health service delivery
KW  - school psychology
KW  - 1993
KW  - Health Service Needs
KW  - Mental Health Services
KW  - School Based Intervention
KW  - School Counseling
KW  - School Psychology
KW  - 1993
DO  - 10.1037/h0088320
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18562-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13536-008
AN  - 2008-13536-008
AU  - Melzer, Peter
AU  - Crane, Alison M.
AU  - Smith, Carolyn B.
T1  - Mouse barrel cortex functionally compensates for deprivation produced by neonatal lesion of whisker follicles.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1993/12//
VL  - 5
IS  - 12
SP  - 1638
EP  - 1652
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Melzer, Peter, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bldg 36, Room 1 A05, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13536-008. PMID: 8124517 Partial author list: First Author & Affiliation: Melzer, Peter; Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090309. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Melzer, Peter. Major Descriptor: Mice; Morphology; Neonatal Period; Responses. Minor Descriptor: Deoxyglucose; Somatosensory Cortex; Brain Lesions (Experimental). Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Dec, 1993. 
AB  - In the murine somatosensory pathway, the metabolic whisker map in barrel cortex derived with the autoradiographic deoxyglucose method is spatially in register with the morphological whisker map represented by the barrels. The barrel cortex of adult mice, in which we had removed three whisker follicles from the middle row of whiskers shortly after birth, contained a disorganized zone surrounded by enlarged barrels with partially disrupted borders. With the fully quantitative autoradiographic deoxyglucose method, we investigated in barrel cortex of such mice the magnitude and the pattern of metabolic responses evoked by the deflection of whiskers. Most remarkably, the simultaneous deflection of six whiskers neighbouring the lesion activated not only the territory of the corresponding barrels, but also the unspecifiable area intercalated between the clearly identified barrels. This metabolic whisker map, unpredictable from the morphological 'barrel' map, may reflect a functional compensation for the deficit in input. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mouse barrel cortex
KW  - deprivation
KW  - neonatal lesion
KW  - whisker follicles
KW  - morphology
KW  - metabolic responses
KW  - 1993
KW  - Mice
KW  - Morphology
KW  - Neonatal Period
KW  - Responses
KW  - Deoxyglucose
KW  - Somatosensory Cortex
KW  - Brain Lesions (Experimental)
KW  - 1993
U1  - Sponsor: Sponsor name not included. Other Details: Fogarty Fellowship. Recipients: Melzer, Peter
DO  - 10.1111/j.1460-9568.1993.tb00232.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13536-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-34700-004
AN  - 2015-34700-004
AU  - Steiner, Heinz
AU  - Gerfen, Charles R.
T1  - Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1993/12//
VL  - 13
IS  - 12
SP  - 5066
EP  - 5081
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gerfen, Charles R., Section of Neuroanatomy, National Institute of Mental Health, Building 36, Room 2D-10, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-34700-004. Partial author list: First Author & Affiliation: Steiner, Heinz; Section of Neuroanatomy, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20161201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Steiner, Heinz. Major Descriptor: Cocaine; Dopamine; Neurons; Rats; Striatum. Minor Descriptor: Dynorphins; Neuropeptides. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 16. Issue Publication Date: Dec, 1993. Publication History: Accepted Date: Jun 10, 1993; Revised Date: Jun 3, 1993; First Submitted Date: Feb 17, 1993. Copyright Statement: Society for Neuroscience. 1993. 
AB  - The effects of the indirect dopamine receptor agonist cocaine in the striatum on levels of mRNAs of the immediate-early gene c-fos and the neuropeptides dynorphin, substance P, and enkephalin were analyzed with quantitative in situ hybridization histochemistry. Both single (acute) and repeated (twice a day for 4 d) systemic injections of cocaine (3.75– 30 mg/kg) to rats resulted in dose-dependent, regionally specific elevations of mRNA expression in striatal neurons. A single drug treatment elevated c-fos mRNA expression, whereas repeated treatments resulted in little c-fos expression but elevated dynorphin mRNA levels. Both the regional and temporal patterns of gene expression revealed an inverse relationship between dynorphin and c-fos expression. This relationship was examined in a time course experiment in which cocaine (30 mg/kg) was administered for 1, 2, 3 or 4 d. Basal levels of dynorphin expression were relatively high in the ventral striatum, including the nucleus accumbens, a ventrolateral region, and an area along the medial bank of the striatum. A single injection of cocaine induced c-fos mRNA in striatal areas with low basal expression of dynorphin. Thus, c-fos mRNA induction was highest in the dorsal central striatum, where basal dynorphin mRNA levels were lowest. In this region, dynorphin mRNA expression increased on subsequent treatment days parallel to diminished c-fos mRNA induction. Changes in substance P. mRNA levels appeared to match directly both the temporal and regional patterns of c-fos induction. Enkephalin mRNA expression was altered, but only slightly, by these cocaine treatments. Statistical analysis of the regional patterns of basal and altered mRNA levels shows a unique inverse relationship between basal dynorphin expression and c-fos induction by cocaine. Further evidence of this relationship is provided by the dose-dependent blockade of cocaine-induced c-fos expression by spiradoline, a dynorphin agonist. Together, these results suggest that the restricted regional pattern of cocaine-induced c-fos expression is related, in part, to the basal level of dynorphin expression, and that cocaine treatment elevates dynorphin expression in striatal regions with a strong c-fos response, thereby limiting subsequent c-fos induction by cocaine. These findings lead to the hypothesis that dynorphin acts to regulate the responsiveness of striatal neurons to dopamine stimulation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - c-fos
KW  - dynorphin
KW  - substance P
KW  - enkephalin
KW  - cocaine
KW  - striatum
KW  - dopamine
KW  - K-receptor
KW  - 1993
KW  - Cocaine
KW  - Dopamine
KW  - Neurons
KW  - Rats
KW  - Striatum
KW  - Dynorphins
KW  - Neuropeptides
KW  - 1993
U1  - Sponsor: Swiss National Science Foundation, Switzerland. Other Details: Fellowship. Recipients: Steiner, Heinz
U1  - Sponsor: Human Frontier Science Program. Recipients: Gerfen, Charles R.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - Gen
ID  - 9999-28521-000
AN  - 9999-28521-000
AU  - Teng, Evelyn L.
AU  - Hasegawa, Kazuo
AU  - Homma, Akira
AU  - Imai, Yukimuchi
AU  - Larson, Eric
AU  - Graves, Amy
AU  - Sugimoto, Keiko
AU  - Yamaguchi, Takenori
AU  - Sasaki, Hideo
AU  - Chiu, Darryl
AU  - White, Lon R.
T1  - Cognitive Abilities Screening Instrument
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1994///
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-28521-000. Other Names: CASI E-1.0. Acronyms: CASI. Partial author list: First Author & Affiliation: Teng, Evelyn L.; University of Southern California School of Medicine, Los Angeles, California, United States. Release Date: 20140512. Correction Date: 20160808. Instrument Type: Screener. Test Location: Appendix, Page 55. Test Format: Responses for the 25 items are open-ended.. Language: English. Constructs: Cognitive Abilities; Classification: Cognitive Processes, Memory, and Decision Making (5400). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). 
AB  - Purpose: The Cognitive Abilities Screening Instrument is a short, practical test that has been designed to serve multiple functions. It can be used (a) as a screening instrument for dementia, (b) to monitor disease progression, and (c) to provide a profile of impairment among various cognitive domains.
AB  - Description: The Cognitive Abilities Screening Instrument (CASI; Teng et al., 1994) provides quantitative assessment on attention, concentration, orientation, short-term memory, long-term memory, language abilities, visual construction, list-generating fluency, abstraction, and judgment. The CASI consists of items either identical or similar to the ones used in the Hasegawa Dementia Screening Scale (HDSS) (Hasegawa, 1983), the Mini-Mental State Examination (MMSE) (Folstein et al., 1975), and the Modified Mini-Mental State (3MS) Test (Teng & Chui, 1987). A new item on judgment has been added because impaired judgment may contribute to a diagnosis of dementia according to the DSM-III-R criteria (American Psychiatric Association, 1987). The CASI consists of the following items according to the order of their administration: place and date of birth, age, number of minutes in an hour, direction of sunset, repeating three words (ex. I am going to say 3 words for you to remember. Repeat them after I have said all three), repeating digits backward, first recall of the three words, serial subtractions of 3, temporal orientation, spatial orientation, generating names of four-legged animals (ex. What animals have four legs? Tell me as many as you can), abstracting similarities between pairs of items, judgment, repeating sentences, executing a simple written command, writing a dictated simple sentence, copying two intersecting pentagons, following a three-step oral command, second recall of three words (ex. What three words did I ask you to remember earlier?), naming five body parts and five common objects, and recalling the five objects for a total of 25 items. Responses on the individual items are grouped into nine cognitive domains: attention, mental manipulation, orientation, long-term memory, short-term memory, language, visual construction, word list fluency, abstraction and judgement. The range of scores on the majority of the domains is from 0 to 10. The CASI total score has a range from 0 to 100. Teng and colleagues (1994) developed English and Japanese versions of the CASI during the course of three workshops. Typical administration time is 15 to 20 minutes. No psychometric data were discussed in the document detailing the development of the measure. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Cognitive Abilities Screening Instrument
KW  - Test Development
KW  - Dementia and Impairment Screening
KW  - Validity
U5  - Cognitive Abilities Screening Instrument (CASI) [Test Development]The Cognitive Abilities Screening Instrument (CASI): A practical test for cross-cultural epidemiological studies of dementia. (AN: 1994-43618-001 from PsycINFO) Teng, Evelyn L.; Hasegawa, Kazuo; Homma, Akira; Imai, Yukimuchi; Larson, Eric; Graves, Amy; Sugimoto, Keiko; Yamaguchi, Takenori; Sasaki, Hideo; Chiu, Darryl; White, Lon R.; Spr, 1994. Source: International Psychogeriatrics. 6(1), Cambridge University Press, United Kingdom; Spr, 1994; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Patients with Dementia; Location: United States; Japan Keywords: Cognitive Abilities Screening Instrument; Test Development; Dementia and Impairment Screening; Subjects: Cognitive Ability; Cognitive Impairment; Dementia; Screening Tests; Test Construction;
U5  - Cognitive Abilities Screening Instrument (CASI) [Test Review]The Cognitive Abilities Screening Instrument (CASI): Data from a cohort of 2524 cognitively intact elderly. (AN: 1999-01578-009 from PsycINFO) McCurry, Susan M.; Edland, Steven D.; Teri, Linda; Kukull, Walter A.; Bowen, James D.; McCormick, Wayne C.; Larson, Eric B.; Oct, 1999. Source: International Journal of Geriatric Psychiatry. 14(10), John Wiley & Sons, US; Oct, 1999; Age Group: Adulthood (18 yrs & older), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Sample: Cognitively Intact Older Adults over Age 65; Location: United States Keywords: Validity; Cognitive Abilities Screening Instrument; Subjects: Cognitive Ability; Screening Tests; Test Validity;
DO  - 10.1037/t28521-000
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DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
ID  - 104784777
T1  - Sex differences in morbidity among respondents classified as alcohol abusers and/or dependent: results of a national survey.
AU  - Chou, S P
Y1  - 1994/01//
N1  - Accession Number: 104784777. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking
KW  - Alcoholism -- Epidemiology
KW  - Morbidity
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Alcohol Drinking -- Prevention and Control
KW  - Alcoholism -- Complications
KW  - Alcoholism -- Rehabilitation
KW  - Cross Sectional Studies
KW  - Female
KW  - Health Status Indicators
KW  - Human
KW  - Incidence
KW  - Male
KW  - Middle Age
KW  - Sex Factors
KW  - United States
SP  - 87
EP  - 93
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 89
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - To date, none of the studies on gender differences in physical morbidity have focused on persons classified as DSM-III-R alcohol abusers and/or dependent in the general population. This Data Note presents data from a nationally representative survey on drinking practices and related problems for the purpose of examining gender differences in physical morbidity among respondents receiving these diagnoses. Results indicated that for certain major sociodemographic subgroups of the population, gender differences in morbidity were significant. The female-to-male odds ratios of these subgroups generally varied within the range of 1.5 and 2.0, reflecting about two times greater odds of experiencing morbid conditions for females when compared to males.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, MD 20857.
U2  - PMID: 8148748.
DO  - 10.1111/j.1360-0443.1994.tb00853.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sutton, Sharyn M.
AU  - Eisner, Ellen J.
AU  - Bloom, Diane L.
AU  - Bloom, Paul N.
T1  - The Mammography Guidelines Controversy: What Do Women Think?
JO  - Advances in Consumer Research
JF  - Advances in Consumer Research
Y1  - 1994/01//
VL  - 21
IS  - 1
M3  - Article
SP  - 387
EP  - 391
PB  - Association for Consumer Research
SN  - 00989258
AB  - Medical researchers have begun in question the appropriateness of guidelines (supported by the National Cancer Institute, American Cancer Society, and others) which recommend that women between forty and fifty obtain mammograms every one to two years. This paper reports on the early stages of a consumer research program which seeks to understand how women are responding to this controversy. The findings have implications both for dealing with the current controversy and for improving preventive health programs of all types. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONSUMER research
KW  - FOCUS groups
KW  - CONSUMER behavior
KW  - MAMMOGRAMS
KW  - WOMEN -- Attitudes
KW  - MIDDLE-aged women -- Health
KW  - PREVENTIVE health services
KW  - GUIDELINES
KW  - SKEPTICISM
KW  - LIKERT scale
KW  - MEDICAL research
KW  - HUMAN information processing -- Psychological aspects
N1  - Accession Number: 83373861; Sutton, Sharyn M. 1; Eisner, Ellen J. 1; Bloom, Diane L. 2; Bloom, Paul N. 2; Affiliations: 1: National Cancer Institute; 2: University of North Carolina; Issue Info: 1994, Vol. 21 Issue 1, p387; Thesaurus Term: CONSUMER research; Thesaurus Term: FOCUS groups; Thesaurus Term: CONSUMER behavior; Subject Term: MAMMOGRAMS; Subject Term: WOMEN -- Attitudes; Subject Term: MIDDLE-aged women -- Health; Subject Term: PREVENTIVE health services; Subject Term: GUIDELINES; Subject Term: SKEPTICISM; Subject Term: LIKERT scale; Subject Term: MEDICAL research; Subject Term: HUMAN information processing -- Psychological aspects; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Levin, Ephraim Y.
T1  - Clinical Nutrition of the Young Child.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/01//
VL  - 59
IS  - 1
M3  - Book Review
SP  - 134
EP  - 134
SN  - 00029165
KW  - Nutrition disorders in children
KW  - Nonfiction
KW  - Brunser, Oscar
KW  - Carrazza, Francisco R.
KW  - Gracey, Michael
KW  - Nichols, Buford Lee, 1931-
KW  - Senterre, Jacques
KW  - Clinical Nutrition of the Young Child (Book)
N1  - Accession Number: 94425674; Levin, Ephraim Y. 1; Affiliations: 1: National Institute of Child Health, and Human Development, Building 61E, Room 4B11 6100 Executive Boulevard, Bethesda, MD 20892; Issue Info: Jan1994, Vol. 59 Issue 1, p134; Subject Term: Nutrition disorders in children; Subject Term: Nonfiction; Reviews & Products: Clinical Nutrition of the Young Child (Book); People: Brunser, Oscar; People: Carrazza, Francisco R.; People: Gracey, Michael; People: Nichols, Buford Lee, 1931-; People: Senterre, Jacques; Number of Pages: 1/2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Breen, Nancy
AU  - Kessler, Larry
T1  - Changes in the Use of Screening Mammography: Evidence From the 1987 and 1990 National Health Interview Surveys.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/01//
VL  - 84
IS  - 1
M3  - Article
SP  - 62
EP  - 67
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Mammography rates reported by women in the National Health Interview Surveys of 1990 and 1987 are examined. Why this screening modality is not more frequently used is explored. Methods. Data from the 1987 and 1990 National Health Interview Surveys, conducted by the National Center for Health Statistics, are cross-tabulated and compared. Results. In 1987, approximately 17% of women over 40 years of age reported having had a screening mammogram in the previous year. In 1990, the rate doubled. Race declined in importance; income and education remained strong, positive predictors of screening. Conclusions. Despite this dramatic increase, two thirds of women are not having screening mammograms. Use was not higher primarily because women did not realize that screening mammography tests for breast cancer in asymptomatic women. Primary care physicians are the main source of health education for screening mammography. The data suggest that public health programs to promote screening mammography should especially target primary care physicians and women with low incomes and education. Likewise, health care providers should ensure that their patients are referred to facilities that deliver high-quality mammography at low cost to make the procedure more accessible. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAMMOGRAMS
KW  - PRIMARY care (Medicine)
KW  - PUBLIC health
KW  - INCOME
KW  - INTERVIEWS
N1  - Accession Number: 9406092475; Breen, Nancy 1 Kessler, Larry 1; Affiliation:  1: Applied Research Branch, National Cancer Institute, Bethesda, Md.; Source Info: Jan1994, Vol. 84 Issue 1, p62; Subject Term: MAMMOGRAMS; Subject Term: PRIMARY care (Medicine); Subject Term: PUBLIC health; Subject Term: INCOME; Subject Term: INTERVIEWS; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rodgers, Anne Brown
AU  - Kessler, Larry G.
AU  - Portnoy, Barry
AU  - Potosky, Arnold L.
AU  - Patterson, Blossom
AU  - Tenney, Janet
AU  - Thompson, Frances E.
AU  - Krebs-Smith, Susan M.
AU  - Breen, Nancy
AU  - Mathews, Odonna
AU  - Kahle, Lisa L.
T1  - "Eat for Health": A Supermarket Intervention for Nutrition and Cancer Risk Reduction.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/01//
VL  - 84
IS  - 1
M3  - Article
SP  - 72
EP  - 76
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The results of an evaluation of "Eat for Health," a supermarket nutrition intervention, are presented. The study tested whether such a program could be successfully carried out and whether it could effect changes in knowledge, attitudes, and food purchasing behavior in line with nutrition and cancer risk reduction guidelines. Methods. The evaluation consisted of an in-store monitoring element, an in-store and telephone consumer survey, and an analysis of matched-pair design, using a total of 40 stores in the intervention and comparison groups, was used. Results. The intervention was successfully implemented and had limited success in changing some food purchasing behaviors. There appeared to be no effect on knowledge and attitudes except for increased awareness of a link between diet and cancer and of the program itself. Conclusions. Despite the intervention's success, limitations of the consumer survey and sales data analyses and the continuing diffusion of nutrition messages throughout society make it difficult to specify the impact of this program on consumer nutrition knowledge and behaviors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUTRITION
KW  - SUPERMARKETS
KW  - CANCER
KW  - CONSUMER behavior
KW  - SURVEYS
N1  - Accession Number: 9406092477; Rodgers, Anne Brown 1 Kessler, Larry G. 2 Portnoy, Barry 2 Potosky, Arnold L. 2 Patterson, Blossom 2 Tenney, Janet 3 Thompson, Frances E. 2 Krebs-Smith, Susan M. 2 Breen, Nancy 2 Mathews, Odonna 3 Kahle, Lisa L. 4; Affiliation:  1: Consultant, Prospect Associates, Rockville, Md.  2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.  3: Consumer Affairs Department, Giant Food Inc, Washington, DC  4: Information Management Services Inc, Silver Spring, Md.; Source Info: Jan1994, Vol. 84 Issue 1, p72; Subject Term: NUTRITION; Subject Term: SUPERMARKETS; Subject Term: CANCER; Subject Term: CONSUMER behavior; Subject Term: SURVEYS; NAICS/Industry Codes: 445110 Supermarkets and Other Grocery (except Convenience) Stores; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wells, Barbara L.
AU  - Brown, Charles C.
AU  - Horm, John W.
AU  - Carleton, Richard A.
AU  - Lasater, Thomas M.
T1  - Who Participates in Cardiovascular Disease Risk Factor Screenings?  Experience with a Religious Organized-Based Program.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/01//
VL  - 84
IS  - 1
M3  - Article
SP  - 113
EP  - 115
PB  - American Public Health Association
SN  - 00900036
AB  - Adult members who declined participation in cardiovascular disease risk factor screenings offered at religious organizations were randomly selected and asked to participate in screenings at their homes. Relationships between screening participation and sociodemographic, behavioral, and physiological measures were examined. Age, knowledge of cardiovascular disease risk factors, body mass index, current smoking status, previous report of elevated blood pressure, current diastolic blood pressure measurement, frequency of worship service attendance, and residential distance from the religious organization predictors of screening response. Those with cospicuous risk factors appeared less likely to initially respond to religious organization site screening invitations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARDIOVASCULAR diseases
KW  - RELIGIOUS institutions
KW  - MEDICAL screening
KW  - DISEASES -- Risk factors
KW  - SOCIODEMOGRAPHIC factors
N1  - Accession Number: 9406092486; Wells, Barbara L. 1 Brown, Charles C. 2 Horm, John W. 3 Carleton, Richard A. 4,5 Lasater, Thomas M. 6,7; Affiliation:  1: Bureau of Primary Health Care, Health Resources and Services Administration, Rockville, Md.  2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.  3: Division of Health Interview Statistics, National Center for Health Statistics, Hyattsville, Md.  4: Division of Cardiology, Memorial Hospital of Rhode Island, Pawtucket  5: Department of Medicine, Brown University, Providence, RI  6: Division of Health Education, Memorial Hospital of Rhode Island  7: Department of Community Health, Brown University; Source Info: Jan1994, Vol. 84 Issue 1, p113; Subject Term: CARDIOVASCULAR diseases; Subject Term: RELIGIOUS institutions; Subject Term: MEDICAL screening; Subject Term: DISEASES -- Risk factors; Subject Term: SOCIODEMOGRAPHIC factors; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 813110 Religious Organizations; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105473295
T1  - Keynote address for the First Annual ATRA Research Institute.
AU  - Gerber L
Y1  - 1994/01//1994-1995
N1  - Accession Number: 105473295. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. 
KW  - Public Speaking
KW  - Recreational Therapy -- Organizations
KW  - Research
KW  - Health Personnel
KW  - Rehabilitation
KW  - Rehabilitation -- History
SP  - 1
EP  - 4
JO  - Annual in Therapeutic Recreation
JF  - Annual in Therapeutic Recreation
JA  - ANNU THER RECREATION
VL  - 5
CY  - Hattiesburg, Mississippi
PB  - American Therapeutic Recreation Association (ATRA)
SN  - 2328-2800
AD  - Chief, Rehabilitation Medicine Department Clinical Center, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Madhavi, B.
AU  - Anand, C.
AU  - Bharathi, A.
AU  - Polasa, H.
T1  - Biotoxic effects of pesticides on symbiotic propertics of Rhizobial sps.
JO  - Bulletin of Environmental Contamination & Toxicology
JF  - Bulletin of Environmental Contamination & Toxicology
Y1  - 1994/01//
VL  - 52
IS  - 1
M3  - Article
SP  - 87
EP  - 94
SN  - 00074861
AB  - The article presents a study which examines the biotoxic effects of 15 commonly used pesticides on the symbiotic properties of the genus Rhizobium. The study uses Rhizobium species and various pesticides as pest control agents including acephate, dichlorvos, and captafol. The study has found that the symbiotic properties of the Rhizobium species IC3342 were more susceptible to the pesticidal treatment out of the three cultures examined.
KW  - Pesticides -- Toxicology
KW  - Symbiosis
KW  - Acephate
KW  - Dichlorvos
KW  - Rhizobium
KW  - Captafol
N1  - Accession Number: 70790669; Madhavi, B. 1; Anand, C. 1; Bharathi, A. 2; Polasa, H. 1; Affiliations: 1: Department of Microbiology, Osmania University, Hyderabad, 500 007 Andhra Pradesh India; 2: Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, 20892 Bethesda USA; Issue Info: Jan1994, Vol. 52 Issue 1, p87; Thesaurus Term: Pesticides -- Toxicology; Thesaurus Term: Symbiosis; Thesaurus Term: Acephate; Thesaurus Term: Dichlorvos; Subject Term: Rhizobium; Subject Term: Captafol; Number of Pages: 8p; Document Type: Article
L3  - 10.1007/BF00197362
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Jun-Mo Yang
AU  - Chipev, Constantin C.
AU  - DiGiovanna, John J.
AU  - Bale, Sherri J.
AU  - Marekov, Lyuben N.
AU  - Steinert, Peter M.
AU  - Compton, John G.
T1  - Mutations in the H1 and 1A Domains in the Keratin 1 Gene in Epidermolytic Hyperkeratosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/01//
VL  - 102
IS  - 1
M3  - Article
SP  - 17
EP  - 23
SN  - 0022202X
AB  - In the autosomal dominant disorder epidermolytic hyperkeratosis, the structural integrity of the keratin intermediate filaments is altered in the suprabasal layers of the epidermis. We and others have used genetic linkage studies and mutation analysis to establish that single amino acid substitutions in either the keratin 1 or keratin 10 chains can cause epidermolytic hyperkeratosis. However, a larger database of mutations is required to better understand the relationship between specific mutations in these keratin chains and their effect on keratin filament structure. A larger database will also provide a catalog that may be useful for genetic counseling purposes. In this paper, we report the identification of three new mutations of the keratin 1 chain of epidermolytic hyperkeratosis probands in highly conserved residues in the H1 or beginning of the 1A rod domain segments. These correspond to regions involved in molecular overlaps between neighboring molecules in keratin filaments. Using an <em>in vitro</em> assay, synthetic peptides bearing these substitutions show diminished capacity to disassemble preformed filaments <em>in vitro</em> in comparison to the wild type peptides. Moreover, analyses of all mutations in epidermolytic hyperkeratosis known to date demonstrate remarkable clustering in the molecular overlap region. We conclude that non-conservative substitutions in the overlap region are likely to interfere with normal keratin filament structure and function, leading to pathology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATOSIS
KW  - MUTATION (Biology)
KW  - KERATIN
KW  - CYTOPLASMIC filaments
KW  - EPIDERMOLYSIS bullosa
KW  - EPIDERMIS
KW  - <em>epidermis</em>
KW  - <em>epidermolysis bullosa simplex</em>
KW  - <em>genodermatoses</em>
KW  - <em>intermediate filaments</em>
N1  - Accession Number: 12371725; Jun-Mo Yang 1 Chipev, Constantin C. 1 DiGiovanna, John J. 2 Bale, Sherri J. 1 Marekov, Lyuben N. 1 Steinert, Peter M. 1 Compton, John G. 1; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskektal and Skin Diseases, Bethesda, Maryland, U.S.A.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1994, Vol. 102 Issue 1, p17; Subject Term: KERATOSIS; Subject Term: MUTATION (Biology); Subject Term: KERATIN; Subject Term: CYTOPLASMIC filaments; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: EPIDERMIS; Author-Supplied Keyword: <em>epidermis</em>; Author-Supplied Keyword: <em>epidermolysis bullosa simplex</em>; Author-Supplied Keyword: <em>genodermatoses</em>; Author-Supplied Keyword: <em>intermediate filaments</em>; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371725
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12371725&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - RPRT
AU  - Falanga, Vincent
AU  - Grinnell, Frederick
AU  - Gilchrest, Barbara
AU  - Maddox, Yvonne T.
AU  - Moshell, Alan
T1  - Workshop on the Pathogenesis of Chronic Wounds.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/01//
VL  - 102
IS  - 1
M3  - Report
SP  - 125
EP  - 127
SN  - 0022202X
AB  - A workshop on the pathogenesis of chronic wounds was held at the National Institutes of Health, Bethesda, Maryland, on January 11-12, 1993. The conference was chaired by Vincent Falanga, University of Miami and co-chaired by Frederick Grinnell of the University of Texas Southwestern Medical School and by Barbara Gilchrest, Boston University School of Medicine. Various questions were raised during the conference on healing of chronic wounds. Areas that need further investigation include the role of oxygen lactate in the stimulation of extracellular matrix and in the fibrotic reaction observed in some chronic wounds.
KW  - CONFERENCES & conventions
KW  - WOUNDS & injuries
KW  - BETHESDA (Md.)
KW  - MARYLAND
KW  - UNITED States
KW  - GRINNELL, Frederick
KW  - GILCHREST, Barbara
N1  - Accession Number: 12371745; Falanga, Vincent 1 Grinnell, Frederick 2,3 Gilchrest, Barbara 4 Maddox, Yvonne T. 5 Moshell, Alan 6; Affiliation:  1: Department of Dermatology, University of Miami, Miami, Florida.  2: Southwestern Medical School, University of Texas, Dallas, Texas.  3: Department of Cell Biology and Neuroscience, University of Texas, Dallas, Texas.  4: Boston University Department of Dermatology, Boston, Massachusetts.  5: NIGMS, National Institutes of Health, Bethesda, Maryland, U.S.A.  6: NIAMS, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1994, Vol. 102 Issue 1, p125; Subject Term: CONFERENCES & conventions; Subject Term: WOUNDS & injuries; Subject Term: BETHESDA (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; People: GRINNELL, Frederick; People: GILCHREST, Barbara; Number of Pages: 3p; Document Type: Report
L3  - 10.1111/1523-1747.ep12371745
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12371745&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107416538
T1  - Subcutaneous octreotide in the treatment of pain in advanced cancer patients.
AU  - De Conno F
AU  - Saita L
AU  - Ripamonti C
AU  - Ventafridda V
Y1  - 1994/01//1994 Jan
N1  - Accession Number: 107416538. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836. 
KW  - Cancer Pain -- Drug Therapy
KW  - Octreotide Acetate -- Therapeutic Use
KW  - Octreotide Acetate -- Administration and Dosage
KW  - Administration, Transcutaneous
KW  - Injections, Subcutaneous
KW  - Crossover Design
KW  - Clinical Trials
KW  - Time Factors
SP  - 34
EP  - 38
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 9
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
AB  - Octreotide is a synthetic somatostatin analogue that has been recently tested by various routes of administration as an analgesic drug for different types of pain. The authors evaluated the analgesic efficacy of a subcutaneous 200-ng bolus of octreotide on somatic and visceral pain from advanced cancer in a randomized, single-blind crossover study. The results in nine cases did not show an analgesic effect superior to that of a placebo. Pain relief was obtained in one case of postprandial visceral pain. This case is discussed in detail, and another possible clinical use for octreotide in a particular form of neoplastic pain is hypothesized. (Reprinted by permission of Elsevier Science Publishing Co., Inc. Copyright 1994 by the U.S. Cancer Pain Relief Committee)
SN  - 0885-3924
AD  - Palliative Care Division, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy
U2  - PMID: 8169458.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
T1  - Role of calcium in respiratory control. / Role du calcium lors du controle respiratoire.
AU  - Hansford, R.G.
JO  - Medicine & Science in Sports & Exercise
JF  - Medicine & Science in Sports & Exercise
Y1  - 1994/01//
VL  - 26
IS  - 1
SP  - 44
EP  - 51
CY  - ; 
SN  - 01959131
N1  - Accession Number: SPH343635; Author: Hansford, R.G.: 1 ; Author Affiliation: 1 Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, United States; No. of Pages: 8; Language: English; Parent Item: SPHP1978; References: 45; General Notes: Illustrated. Symposium: Control of aerobic energy metabolism in skeletal muscle. INSEP, PARIS. Cote: PE50. Acces: copie. K5.1 - PHYSIOLOGIE ET ANATOMIE DES APS, GENERALITES; Publication Type: Article; Update Code: 19940401; SIRC Article No.: 343635
N2  - Ca2 plus ions activate four mitochondrial enzymes (viz. glycerol 3-phosphate dehydrogenase, pyruvate dehydrogenase phosphatase, NAD-isocitrate dehydrogenase and 2-oxoglutyarate dehydrogenase) that are involved in substrate for oxidative phosphorylation. As cytosol Ca2 plus, and presumably mitochondrial Ca2 plus, concentrations are raised during muscle contraction, this is thought to provide a mechanism whereby the activity of oxidative phosphorylation is raised in working muscle without the necessity of unacceptably large decreases in adenine nucleotide phosphorylation potential. These ideas are explored in this article, with particular reference to the activation of pyruvate dehydrogenase in cardiac and skeletal muscle preparations and its dependence upon both cytosolic and intramitochondrial Ca2 plus ion concentrations.
N2  - (HERACLES) Points developpes dans cette etude: les ions Ca2+ activent 4 enzymes mitochondriales qui participent a la deshydrogenation des substrats et a la production de NADH comme substrat de la phosphorylation. Les concentrations en Ca2+ cytosoliques augmentent lors des contractions musculaires entrainant un mecanisme grace auquel l ' activite de la phosphorylation oxydative s ' eleve dans le muscle actif sans necessiter de baisse importante du potentiel de la phosphorylation de adenines nucleotides.
KW  - *MUSCLE metabolism
KW  - *MUSCLES
KW  - *CALCIUM
KW  - *PHOSPHORYLATION
KW  - PYRUVATES
KW  - CALCIUM
KW  - MITOCHONDRIE
KW  - SYSTEME-RESPIRATOIRE
KW  - ENZYME
KW  - BIOCHIMIE
KW  - MUSCLE
KW  - CONTRACTION-MUSCULAIRE
L2  - http://articles.sirc.ca/search.cfm?id=343635
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UR  - http://articles.sirc.ca/search.cfm?id=343635
DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
T1  - Fluid ingestion during exercise in 25 degree C water at the surface and 5.5 ATA. / Ingestion de liquides lors d ' un exercice dans de l ' eau a 25 degres C en surface et a 5,5 ATA.
AU  - Doubt, T.J.
AU  - Deuster, P.A.
JO  - Medicine & Science in Sports & Exercise
JF  - Medicine & Science in Sports & Exercise
Y1  - 1994/01//
VL  - 26
IS  - 1
SP  - 75
EP  - 80
CY  - ; 
SN  - 01959131
N1  - Accession Number: SPH343639; Author: Doubt, T.J.: 1 Author: Deuster, P.A. ; Author Affiliation: 1 Cardiac Diseases Branch, DHVD, National Heart, Lung and Blood Institute, Federal Building, Room 3C06, Bethesda, MD 20892, United States; No. of Pages: 6; Language: English; Parent Item: SPHP1978; References: 21; General Notes: Illustrated. INSEP, PARIS. Cote: PE50. Acces: copie. K3 - METHODES DE MESURE ET DE DIAGNOSTIC, TESTS / K5.4 - METABOLISME, METABOLISME ENERGETIQUE / K5.5 - ADAPTATION : TEMPERATURE, PRESSION, ALTITUDE, POLLUTION...; Publication Type: Article; Update Code: 19940401; SIRC Article No.: 343639
N2  - To determine if drinking fluid altered exercise and thermal variables during 2-hr immersions in 25 degree C water, 11 male subjects were tested breathing air at 1 ATA and HeO2 at 5.5 ATA (PO2 = 0.42 ATA). Each immersion consisted of four periods of 5-min rest, 5-min leg exercise at 50 W, and 20 min of exercise at 68 plus/minus 3 percent VO2max. One test at each depth was done with no fluid (NF); one test was done with subjects consuming 125 ml of a 7 percent glucose polymer (GP) solution every 30 min (total intake = 500 ml). Compared with NF, GP increased urine volume by 469 plus/minus 118 and 443 plus/minus 82 ml at 1 and 5.5 ATA. Mean minute ventilation (VE) was reduced at depth by 10.1 plus/minus 0.6 and 5.1 plus/minus 0.61.min-1 for NF and GP, respectively (P less than 0.05). GP trials reduced ventilatory equivalent (VEQ, VE/VO2) at 1 ATA, but increased it at 5.5 ATA, secondary to a small change in VE. Exercise heart rate was slightly lower at 5.5 ATA, but O2 pulse was the same among all conditions (17.2 plus/minus 0.1 ml O2.beat-1). Rectal temperature increased 0.71 plus/minus 0.04 degree C for all conditions. Total body heat flux and insulation were unaffected by fluid or hyperbaric treatments. These results indicate that drinking fluid during immersed exercise does not change fluid balance or thermal status at depths to 5.5 ATA. The modest changes in VEQ noted with fluid intake or hyperbaric exposure reflect inconsequential alterations in cardiopulmonary efficiency.
N2  - (HERACLES) Etude visant a determiner si la consommation de liquides modifie les variables thermiques et l ' exercice physique lors d ' une immersion de 2 h a 25 degres C chez onze sujets respirant de l ' air a 1 ATA et Hc Oxygene a 5,5 ATA (VO2 = 0,42 ATA). Chaque immersion comprenait 4 periodes de 5 min. de repos, 5 min d ' exercice realise a l ' aide des jambes a 50 W et 20 min a 68 % de VO2 max. Les sujets consommaient 125 ml d ' une solution de polymere du glucose a 7 %.
KW  - *EXERCISE
KW  - *DEEP diving
KW  - *OXYGEN -- Physiological transport
KW  - *RESPIRATION
KW  - WATER immersion
KW  - GLUCOSE POLYMER
KW  - UNDERWATER DIVING
KW  - SEXE-MASCULIN
KW  - BOISSON
KW  - GLUCOSE
KW  - IMMERSION
KW  - PUISSANCE-MAXIMALE-AEROBIE
KW  - ACTIVITE-PHYSIQUE
KW  - JAMBE
KW  - TEMPERATURE-CORPORELLE
KW  - VENTILATION
KW  - HYDRATATION
L2  - http://articles.sirc.ca/search.cfm?id=343639
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UR  - http://articles.sirc.ca/search.cfm?id=343639
DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
T1  - Radiofrequency Catheter Atrioventricular Node Ablation in Patients with Permanent Cardiac Pacing Systems.
AU  - Chang, Anthony C.
AU  - McAreavey, Dorothea
AU  - Tripodi, Dorothy
AU  - Fananapazir, Lameh
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
Y1  - 1994/01//
VL  - 17
IS  - 1
SP  - 65
EP  - 69
SN  - 01478389
N1  - Accession Number: 17568496; Author: Chang, Anthony C.: 1 Author: McAreavey, Dorothea: 1 Author: Tripodi, Dorothy: 1 Author: Fananapazir, Lameh: 1 ; Author Affiliation: 1 Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20050712
N2  - Following successful BF ablation of the atrioventricular node (AVN), temporary pacing is necessary prior to insertion of a permanent pacemaker. The risks and inconvenience of temporary pacing could be avoided if a permanent pacemaker is already in place. This study reports the feasibility of RF ablation of the AVN in 27 patients (age 55 ± 17 years, 15 males) with hypertrophic cardiomyopathy and pacemakers. Indications for A VN ablation were drug refractory atrial fibrillation in 24 patients, and rapid A VN conduction preventing septal pre-excitation by DDD pacemaker, inserted for relief of left ventricular outflow obstruction, in three cases. Sixteen patients had DDD devices and 11 patients had VVI devices. During RF ablation, each pacemaker was programmed to VVI at 50 beats/min. The ablation catheter was manipulated with fluoroscopic control to avoid close contact with or disturbance of the pacing leads. In 16 patients, RF ablation was performed immediately following pacemaker implantation but in the remaining patients, the AVN was ablated 6-32 months after pacemaker implantation. The power applied was 25-50 watts for a duration of 15-60 seconds. AV block was achieved in all cases but required 34±36 applications for 16.5 ± 17.8 min/case. RF ablation consistently caused reversion to magnet rate in one patient and temporarily inhibited appropriate pacemaker discharge in another. However, no other pacemaker or lead malfunction was detected so that temporary pacing was not required in any case. At 6 ± 3 months follow-up, all pacemakers were functioning normally without alteration in pacing parameters from baseline. Thus. RF ablation of the AVN can be performed safely in the presence of a recently implanted permanent pacemaker, without temporary pacing. ABSTRACT FROM AUTHOR
KW  - *ATRIOVENTRICULAR node
KW  - *HEART conduction system
KW  - *CARDIAC pacing
KW  - *ARRHYTHMIA -- Treatment
KW  - *HYPERTROPHIC cardiomyopathy
KW  - *HEART diseases
KW  - CATHETER ablation
KW  - AV node
KW  - cardiac pacing systems
KW  - radiofrequency ablation
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2015-36258-003
AN  - 2015-36258-003
AU  - Behar, T. N.
AU  - Schaffner, A. E.
AU  - Colton, C. A.
AU  - Somogyi, R.
AU  - Olah, Z.
AU  - Lehel, C.
AU  - Barker, J. L.
T1  - GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/01//
VL  - 14
IS  - 1
SP  - 29
EP  - 38
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Behar, T. N., NIH, Building 36, Room 2CO2, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36258-003. PMID: 8283236 Partial author list: First Author & Affiliation: Behar, T. N.; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20170223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Gamma Aminobutyric Acid; Nerve Growth Factor; Neurons. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Jan, 1994. Publication History: Accepted Date: Jun 15, 1993; Revised Date: May 19, 1993; First Submitted Date: Feb 3, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - During CNS development, neuroblasts proliferate within germinal zones of the neuroepithelium, and then migrate to their final positions. Although many neurons are thought to migrate along processes of radial glial fibers, increasing evidence suggests environmental factors also influence nerve cell movement. Extracellular matrix molecules are thought to be involved in guiding neuronal migration, and molecules such as NGF and GABA exert trophic effects on immature neurons. The nature of the signals that initiate and direct neuroblast migration, however, is unknown. In vitro, NGF and GABA promote neurite outgrowth from cultured cells, and NGF induces axonal chemotaxis (directed migration along a chemical gradient). At earlier developmental stages, these molecules could influence neuroblast movement. Therefore, we investigated whether these molecules induce embryonic neuronal migration. Using an in vitro microchemotaxis assay, we show that rat embryonic spinal cord neurons migrate toward picomolar NGF and femtomolar GABA beginning at embryonic day 13 (E13). Cells exhibit chemotactic responses to NGF while GABA stimulates chemokinesis (increased random movement). GABA effects are mimicked by muscimol and inhibited by bicuculline and picrotoxin, suggesting GABA motility signals are mediated by GABA receptor proteins. Expression of GABA receptors by embryonic cord cells has been previously reported (Mandler et al., 1990; Walton et al., 1993). We used polymerase chain reaction analysis to demonstrate the presence of NGF and trk mRNA in E13 and E14 cord cells, indicating the cells express message for both NGF and high-affinity NGF receptors. lmmunohistochemistry of E13 spinal cord sections indicates that NGF and GABA colocalize in fibers close to the target destinations of migrating neurons, suggesting diffusible gradients of these molecules provide chemoattractant signals to migratory cells. Thus, in vitro, neuroblast migration is induced by specific signaling molecules that are present in the developing spinal cord, and may stimulate migration of embryonic neurons prior to synaptogenesis. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - migration
KW  - development
KW  - CNS
KW  - chemoattractant
KW  - motility
KW  - rat
KW  - 1994
KW  - Central Nervous System
KW  - Gamma Aminobutyric Acid
KW  - Nerve Growth Factor
KW  - Neurons
KW  - Rats
KW  - 1994
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-36258-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36258-030
AN  - 2015-36258-030
AU  - Smith, Carolyn L.
T1  - Cytoskeletal movements and substrate interactions during initiation of neurite outgrowth by sympathetic neurons in vitro.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/01//
VL  - 14
IS  - 1
SP  - 384
EP  - 398
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Smith, Carolyn L., Laboratory of Neural Control, NINDS, National Institutes of Health, Building 36, Room 2A29, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36258-030. Partial author list: First Author & Affiliation: Smith, Carolyn L.; Laboratory of Neural Control, NINDS, National Institutes of Health, Bethesda, MD, US. Release Date: 20170223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Axons; Neurons; Sympathetic Nervous System. Minor Descriptor: Chickens. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 15. Issue Publication Date: Jan, 1994. Publication History: Accepted Date: Jul 13, 1993; Revised Date: Jul 6, 1993; First Submitted Date: May 12, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - The initial outgrowth of neurites from chick sympathetic neurons grown in vitro was investigated by time-lapse microscopy with laser-scanning and conventional light microscopes. Video-enhanced contrast, differential interference contrast optics (VECDIC) were used to monitor movements of neuronal cytoplasm, as well as the movements of small beads attached to the surface membrane, and interference reflection microscopy (KIM) was used to determine the concomitant pattern of attachment to the growth substrate (polyornithine or laminin). Related changes in the distributions of actin filaments, microtubules, and neurofilaments were determined by fluorescence labeling methods. Neurite formation on both substrates entailed invasion of the actin cores of filopodia by cytoplasm containing microtubules and neurofilaments. Small beads attached to the surface membrane surrounding the cytoplasm moved outward simultaneously with the cytoplasm. Cytoplasm invaded filopodia of neurons plated on laminin soon after attachment to the substrate or, for neurons generated in vitro, within as little as 3 min after cytokinesis. However, cytoplasm invaded filopodia of neurons grown on polyornithine only when they contacted a three-dimensional object such as another cell or a large, polyornithine-coated polystyrene bead. The observation that adhesion of filopodia to polyornithine-coated beads can initiate neurite formation is inconsistent with the commonly held view that neurite formation requires adhesion mediated by specific cell adhesion molecules. Simultaneous IRM and DIC imaging showed that cytoplasm invaded filopodia when only their tips were closely apposed to a substrate but not when they were closely apposed to a substrate along their entire lengths. These findings help to elucidate the mechanisms by which interactions between the cytoskeleton and the growth substrate initiate and produce the neuronal movements that lead to the formation of neurites. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - axon outgrowth
KW  - growth cone motility
KW  - growth cone guidance
KW  - neuronal polarity
KW  - microtubules
KW  - actin filaments
KW  - 1994
KW  - Axons
KW  - Neurons
KW  - Sympathetic Nervous System
KW  - Chickens
KW  - 1994
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-36258-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107303228
T1  - Process evaluation in the multicenter Child and Adolescent Trial for Cardiovascular Health (CATCH)
AU  - Stone EJ
AU  - McGraw SA
AU  - Osganian SK
AU  - Elder JP
Y1  - 1994/01/02/1994 Suppl 2
N1  - Accession Number: 107303228. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 1994 Suppl 2. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 8108606. 
KW  - Evaluation Research
KW  - Cardiovascular Diseases -- Prevention and Control
KW  - School Health Education
KW  - Health Behavior
KW  - Child
KW  - Adolescence
SP  - S1
EP  - 142
JO  - Health Education Quarterly
JF  - Health Education Quarterly
JA  - HEALTH EDUC Q
VL  - 19
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0195-8402
AD  - CATCH Project Administrator, Prevention and Demonstration Research Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Federal Building, Room 604A, Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107303228&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Block, Gladys
AU  - Sinha, Rashmi
AU  - Gridley, Gloria
T1  - Collection of dietary-supplement data and implications for analysis.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/01/03/Jan1994 Supplement 2
M3  - Article
SP  - 232S
EP  - 239S
SN  - 00029165
AB  - The role of nutrient intake in disease outcome is often examined in epidemiologic studies. Most such studies conducted in the United States, however, have not included fortified foods or vitamin supplements. In the United States, these are important sources of vitamins C and E, but not of β-carotene. In addition, the importance of these nutrient sources varies by race, sex, and age. Failure to include these sources produces errors in nutrient estimates, notable misclassification of individuals with regard to their total intake, and rankings of intake that bear little or no relationship to blood concentrations of those nutrients. Implications for statistical analysis are also considered. Risk analyses in which nutrients from supplements are handled as control variables or arc analyzed separately may impair the ability to detect associations between total nutrient intake and disease risk. The additional source of misclassification of nutrient status for vitamins C and E and other nutrients derived from fortified foods or supplements would make it more difficult to obtain significant and consistent results in etiologic studies of these nutrients; this has not been a factor for β-carotene, which is derived almost exclusively from fruits and vegetables. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - β-carotene
KW  - dietary supplements
KW  - epidemiologic methods
KW  - misclassification
KW  - Vitamin C
KW  - vitamin E
KW  - vitamins
N1  - Accession Number: 94403333; Block, Gladys 1,2; Sinha, Rashmi 1,2; Gridley, Gloria 1,2; Affiliations: 1: Department of Nutrition, University of California, Berkeley; 2: Division of Cancer Etiology, National Cancer Institute, Bethesda, MD; Issue Info: Jan1994 Supplement 2, p232S; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: dietary supplements; Author-Supplied Keyword: epidemiologic methods; Author-Supplied Keyword: misclassification; Author-Supplied Keyword: Vitamin C; Author-Supplied Keyword: vitamin E; Author-Supplied Keyword: vitamins; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107400541
T1  - HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood.
AU  - Clerici M
AU  - Levin JM
AU  - Kessler HA
AU  - Harris A
AU  - Berzofsky JA
AU  - Landay AL
AU  - Shearer GM
AU  - Clerici, M
AU  - Levin, J M
AU  - Kessler, H A
AU  - Harris, A
AU  - Berzofsky, J A
AU  - Landay, A L
AU  - Shearer, G M
Y1  - 1994/01/05/
N1  - Accession Number: 107400541. Language: English. Entry Date: 19950301. Revision Date: 20161112. Publication Type: journal article; research; statistics; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - HIV-1
KW  - Immunity, Cellular
KW  - Occupational Exposure
KW  - Blood
KW  - Health Personnel
KW  - HIV Infections -- Transmission
KW  - T Lymphocytes
KW  - In Vitro Studies
KW  - HIV Seropositivity
KW  - Adult
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Human
SP  - 42
EP  - 46
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 271
IS  - 1
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To evaluate human immunodeficiency virus (HIV) type 1-specific cellular immune responses in HIV-seronegative health care workers with occupational high-risk exposures to HIV-infected (HIV-positive) patients.Design: Peripheral blood mononuclear cells (PBMCs) were obtained after occupational exposures to HIV, and PBMCs from health care workers exposed to HIV-negative patients served as controls. The PBMCs were stimulated in vitro with HIV envelope synthetic peptides. Interleukin 2 (IL-2) production was measured in a bioassay. The HIV antibody status was determined by standard enzyme-linked immunosorbent assays. Exposed individuals were also evaluated for HIV proviral DNA by polymerase chain reaction techniques.Participants: The PBMCs from eight health care workers with high-risk exposures and nine control health care workers were studied.Results: The PBMCs from all individuals showed strong IL-2 production to control antigens, indicating intact T-helper function. Interleukin 2 production to HIV peptides was detected in PBMCs from six of eight HIV-exposed individuals, but in only one of the nine health care workers exposed to HIV-negative body fluids (P < .008). None of the HIV-exposed health care workers became infected as determined by negative HIV antibody and polymerase chain reaction analysis after follow-up evaluation that ranged from 8 to 64 weeks.Conclusion: Human immunodeficiency virus-specific T-helper activity was detected in six (75%) of eight HIV-negative health care workers with exposure to HIV-positive body fluids. Potent HIV-specific T-helper activity was detectable 4 to 8 weeks after the exposure and was lost in individuals followed up for 8 to 64 weeks. Three health care workers remained responsive at 8, 19, and 24 weeks. Exposure to HIV without evidence of subsequent infection appears to result in activation of cellular immunity without activation of antibody production.
SN  - 0098-7484
AD  - National Cancer Institute, National Institutes of Health, Experimental Immunology Branch, Bethesda, MD 20892
AD  - National Cancer Institute, National Institutes of Health, Experimental Immunology Branch, Bldg 10, Rm 4B17, Bethesda, MD 20892
U2  - PMID: 8258885.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Hammami, Muhammad
AU  - Metz, David C.
AU  - Fishbeyn, Vitaly A.
AU  - Jensen, Robert T.
AU  - Craig, Wendy Y.
AU  - Ritchie, Robert F.
AU  - Wanner, Christoph
AU  - Bartens, Werner
AU  - Schreiber, Martin
AU  - Halperin, Mitchell L.
AU  - Velazquez, Heino
AU  - Ellison, David H.
AU  - Perazella, Mark A.
AU  - Cheng, Tsung O.
AU  - Doorduijn, Jeanette K.
AU  - Wismans, Pieter J.
AU  - Stuiver, Peter C.
AU  - Fisher, Jejfrey
AU  - Badesch, David B.
AU  - Voelkel, Norbert F.
T1  - Letters.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1994/01/15/
VL  - 120
IS  - 2
M3  - Letter
SP  - 165
EP  - 172
SN  - 00034819
AB  - Comments on several articles about internal medicine.  Treatment approach for Zollinger-Ellison syndrome after gastrinoma resection; Levels of lipoproteins in nephrotic syndrome; Role of urea excretion rate in the development of hyperkalemia.
KW  - INTERNAL medicine
KW  - ZOLLINGER-Ellison syndrome
KW  - NEPHROTIC syndrome
KW  - UREA
KW  - TREATMENT
N1  - Accession Number: 6987131; Hammami, Muhammad 1 Metz, David C. 2 Fishbeyn, Vitaly A. 2 Jensen, Robert T. 2 Craig, Wendy Y. 3 Ritchie, Robert F. 3 Wanner, Christoph 4 Bartens, Werner 4 Schreiber, Martin 5 Halperin, Mitchell L. 5 Velazquez, Heino 6 Ellison, David H. 6 Perazella, Mark A. 6 Cheng, Tsung O. 7 Doorduijn, Jeanette K. 8 Wismans, Pieter J. 8 Stuiver, Peter C. 8 Fisher, Jejfrey 9 Badesch, David B. 10 Voelkel, Norbert F. 10; Affiliation:  1: King Faisal Specialist Hospital and Research Centre, Saudi Arabia  2: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda  3: Foundation for Blood Research, Scarborough  4: University Hospital of Freiburg, Germany  5: St. Michael's Hospital, University of Toronto, Toronto, Ontario  6: Yale University School of Medicine, New Haven  7: George Washington University, Washington  8: Havenziekenhuis, Rotterdam, The Netherlands  9: New York Hospital-Cornell Medical Center, New York  10: University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver; Source Info: 1/15/94, Vol. 120 Issue 2, p165; Subject Term: INTERNAL medicine; Subject Term: ZOLLINGER-Ellison syndrome; Subject Term: NEPHROTIC syndrome; Subject Term: UREA; Subject Term: TREATMENT; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 8p; Document Type: Letter; Full Text Word Count: 8703
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donella-Deana, Ariana
AU  - Krinks, Marie H.
AU  - Ruzzene, Maria
AU  - Klee, Claude
AU  - Pinna, Lorenzo A.
T1  - Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B).
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/01/15/
VL  - 219
IS  - 1/2
M3  - Article
SP  - 109
EP  - 117
PB  - Wiley-Blackwell
SN  - 00142956
AB  - 38 (6–32 residues) enzymically phosphorylated synthetic peptides have been assayed as substrates for calcineurin, a Ca²+/calmodulin-dependent protein phosphatase (PP-2B) belonging to the family of Ser/Thr-specific enzymes but also active on phophotyrosine residues. Many peptides reproduce, with suitable modifications, naturally occurring phosphoacceptor sites. While protein phosphatases 2A and 2C are also very active on short phosphopeptides, an extended N-terminal stretch appears to be a necessary, albeit not sufficient, condition for an optimal dephosphorylation, comparable to that of protein substrates, of both phophoseryl and phosphotyrosyl peptides by calcineurin. This finding corroborates the view that higher-order structure is an important determinant for the substrate specificity of calcineurin. However, a number of shorter peptides are also appreciably dephosphorylated by this enzyme, their efficiency as substrates depending on local structural features. All the peptides that are appreciably dephosphorylated by calcineurin contain basic residue(s) on the N-terminal side. A basic residue located at position −3 relative to the phosphorylated residue plays a particularly relevant positive role in determining the dephosphorylation of short phsophopeptides. Acidic residue(s) adjacent to the C-terminal side of the phospho-amino acid are conversely powerful negative determinants, preventing the dephosphorylation of otherwise suitable peptide substrate. However, calcineurin displays an only moderate preference for phosphothreonyl peptides which are conversely strikingly preferred over their phophoseryl counterparts by the other classes of Ser/Thr-specific protein phosphatases. Moreover calcineurin does not perceive as a strong negative determinant the motif Ser/Thr-Pro in peptides where this motif prevents dephosphorylation by the other classes of Ser/Thr protein phosphatases. Whenever tested on phosphotyrosyl peptides, calcineurin exhibits a specificity which is strikingly different from that of T-cell protein tyrosine phosphatase, a bona fide protein tyrosine phosphatase. In particular while the latter enzyme is especially active toward a number of phsophopeptides reproducing the phosphoacceptor sites of src products and of calmodulin whose N-terminal moieties are predominantly acidic, the artificial substrate phospho-angiotensin II, bearing an arginine residue at position −2, is far preferred by calcineurin over all phosphotyrosyl peptides of similar size. Collectively taken these results show that the specificity of calcineurin, rather than resting on a given consensus sequence, is determined by a variety of primary and higher-order structural features conferring to it an overall selectivity that is different from those of any other known protein phosphatase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEPTIDE synthesis
KW  - PHOSPHORYLATION
KW  - CHROMOGENIC compounds
KW  - PROTEINS
KW  - T cells
KW  - PROTEIN-tyrosine phosphatase
N1  - Accession Number: 12213488; Donella-Deana, Ariana 1 Krinks, Marie H. 2 Ruzzene, Maria 1 Klee, Claude 2 Pinna, Lorenzo A. 1; Affiliation:  1: Dipartimento di Chimica Biologica and Centro per lo Studio della Fisiologia Mitocondriale del Consiglio Nazionale delle Ricerche, Universitá di Padova, Padova, Italy  2: National Cancer Institute, Laboratory of Biochemistry, National Institutes of Health, Bethesda, USA; Source Info: 1/15/94, Vol. 219 Issue 1/2, p109; Subject Term: PEPTIDE synthesis; Subject Term: PHOSPHORYLATION; Subject Term: CHROMOGENIC compounds; Subject Term: PROTEINS; Subject Term: T cells; Subject Term: PROTEIN-tyrosine phosphatase; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yamazaki, Toshimasa
AU  - Nicholson, Linda K.
AU  - Torchia, Dennis A.
AU  - Stahl, Stephan J.
AU  - Kaufman, Joshua D.
AU  - Wingfield, Paul T.
AU  - Domaille, Peter J.
AU  - Campbell-Burk, Sharon
T1  - Secondary structure and signal assignments of human-immunodeficiency-virus-1 protease complexed to a novel, structure-based inhibitor.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/01/15/
VL  - 219
IS  - 1/2
M3  - Article
SP  - 707
EP  - 712
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We report comprehensive NMR studies in solution of the human-immunodeficiency-virus (HIV)-I protease. Stable solutions of the protease were obtained by complexing the protein to a designed cyclic urea inhibitor DMP 323. A variety of triple-resonance experiments provided essentially complete ¹H, ¹C and 15N NMR signal assignments of the protease. These assignments, together with shrift-range NOE constraints, coupling constants and hydrogen-exchange data. Yielded the secondary structure of the protease in solution. The results reported herein open the way to the determination of the high-resolution thee-dimensional solution structures of protease/inhibitor complexes, as well as to studies of protease dynamics and solvent interactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEAR magnetic resonance
KW  - HIV (Viruses)
KW  - PROTEOLYTIC enzymes
KW  - UREA
KW  - ANTIVIRAL agents
KW  - X-ray diffraction
N1  - Accession Number: 12218259; Yamazaki, Toshimasa 1 Nicholson, Linda K. 1 Torchia, Dennis A. 1 Stahl, Stephan J. 2 Kaufman, Joshua D. 2 Wingfield, Paul T. 2 Domaille, Peter J. 3 Campbell-Burk, Sharon 3; Affiliation:  1: Bone Research Branch, National Institute of Dental Research, Bethesda, USA  2: Protein Expression Laboratory, Office of the Director, National Institutes of Health, Bethesda, USA  3: Department of Chemical and Physical Sciences, DuPont Merck Pharmaceutical Company, Wilmington, USA; Source Info: 1/15/94, Vol. 219 Issue 1/2, p707; Subject Term: NUCLEAR magnetic resonance; Subject Term: HIV (Viruses); Subject Term: PROTEOLYTIC enzymes; Subject Term: UREA; Subject Term: ANTIVIRAL agents; Subject Term: X-ray diffraction; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104784967
T1  - Do the benefits of nicotine help beat the addiction rap?
AU  - Henningfield, J E
Y1  - 1994/02//
N1  - Accession Number: 104784967. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Nicotine -- Administration and Dosage
KW  - Smoking Cessation
KW  - Arousal -- Drug Effects
KW  - Cognition -- Drug Effects
KW  - Nicotine -- Adverse Effects
KW  - Self Administration
SP  - 135
EP  - 146
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 89
IS  - 2
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0965-2140
AD  - Clinical Pharmacology Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224.
U2  - PMID: 8173474.
DO  - 10.1111/j.1360-0443.1994.tb00865.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Muntaner, Caries
AU  - Wolyniec, Paula
AU  - McGrath, John
AU  - Pulver, Ann E.
T1  - Psychotic Inpatients' Social Class and Their First Admission to State or Private Psychiatric Baltimore Hospitals.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/02//
VL  - 84
IS  - 2
M3  - Article
SP  - 287
EP  - 289
PB  - American Public Health Association
SN  - 00900036
AB  - Social class differences were investigated among patients admitted to public and private psychiatric hospitals. Participants included first admission White psychotic men admitted to Baltimore metropolitan area hospitals between 1983 and 1989. After adjusting for age and diagnosis, patients with low levels of skills/credentials were found to be more likely than patients with higher levels to be admitted to state psychiatric hospitals. These findings underscore the persistence of social class as a determinant of differences in the use of psychiatric care. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL classes
KW  - MENTALLY ill -- Rehabilitation
KW  - HOSPITALS -- Admission & discharge
KW  - BALTIMORE (Md.)
KW  - MARYLAND
N1  - Accession Number: 9406092519; Muntaner, Caries 1,2 Wolyniec, Paula 2 McGrath, John 2 Pulver, Ann E. 2; Affiliation:  1: National Institute of Mental Health, Bethesda, Md.  2: Epidemiology Genetics Program, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Md.; Source Info: Feb1994, Vol. 84 Issue 2, p287; Subject Term: SOCIAL classes; Subject Term: MENTALLY ill -- Rehabilitation; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: BALTIMORE (Md.); Subject Term: MARYLAND; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cummings, K. Michael
AU  - Pechacek, Terry
AU  - Shopland, Donald
T1  - The Illegal Sale of Cigarettes to US Minors: Estimates by State.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/02//
VL  - 84
IS  - 2
M3  - Article
SP  - 300
EP  - 302
PB  - American Public Health Association
SN  - 00900036
AB  - Data available from recent national surveys on the cigarette consumption and purchasing practices of teenage smokers were used to generate state-specific estimates of the number of teenage smokers and cigarette sales to minors. In 1991, approximately 2.7 million teenage cigarette smokers consumed an average of 28.3 million cigarettes per day (516 million packs per year). An estimated 255 million packs of cigarettes were sold illegally to minors in 1991. To make cigarettes and other tobacco products less accessible to minors, policymakers should consider implementing various legislative and economic measures such as banning cigarette vending machines and raising tobacco excise taxes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIGARETTES -- Marketing
KW  - MINORS
KW  - YOUNG consumers
KW  - CIGARETTE smokers
KW  - SMOKING
N1  - Accession Number: 9406092523; Cummings, K. Michael 1 Pechacek, Terry 2 Shopland, Donald 3; Affiliation:  1: Department of Cancer Control and Epidemiology, Roswell Park Cancer Institute, Buffalo, NY  2: Department of Social and Preventive Medicine, School of Medicine, State University of New York, Buffalo  3: National Cancer Institute, Rockville, Md.; Source Info: Feb1994, Vol. 84 Issue 2, p300; Subject Term: CIGARETTES -- Marketing; Subject Term: MINORS; Subject Term: YOUNG consumers; Subject Term: CIGARETTE smokers; Subject Term: SMOKING; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Suomi, Stephen I.
T1  - The Use and Modification of Bone Tools by Capuchin Monkeys1.
JO  - Current Anthropology
JF  - Current Anthropology
Y1  - 1994/02//
VL  - 35
IS  - 1
M3  - Article
SP  - 75
EP  - 77
SN  - 00113204
AB  - The article presents information related to a research on the use and modification of bone tools by Capuchin Monkeys. Nine capuchins in two captive groups were used in the experiment. Three of nine capuchin monkeys in the experiment used bone fragments to crack hard-shelled nuts and to cut acetate. Bone fragments were used by one of these monkeys as both chisels and hammers. It used a stone to modify bone-fragment tools. The abilities exhibited by these monkeys in tool-using and tool-making were found analogous to those documented for capuchins with regard to stone tools .
KW  - ARCHAEOLOGY research
KW  - ANTHROPOLOGICAL research
KW  - CAPUCHIN monkeys
KW  - MONKEYS as laboratory animals
KW  - CHISELS
KW  - BONES
KW  - HAMMERS
KW  - MONKEYS
KW  - TOOLS
N1  - Accession Number: 22493182; Westergaard, Gregory Charles 1 Suomi, Stephen I. 1; Affiliation:  1: Laboratory of Comparative Ethology, National institute of Child Health and Human Development, P.O. Box 529, Poolesville, Md. 20837, U.S.A.; Source Info: Feb1994, Vol. 35 Issue 1, p75; Subject Term: ARCHAEOLOGY research; Subject Term: ANTHROPOLOGICAL research; Subject Term: CAPUCHIN monkeys; Subject Term: MONKEYS as laboratory animals; Subject Term: CHISELS; Subject Term: BONES; Subject Term: HAMMERS; Subject Term: MONKEYS; Subject Term: TOOLS; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105850195
T1  - Cervical neoplasia in the patient with HIV infection.
AU  - Stratton P
AU  - Ciacco KH
Y1  - 1994/02//1994 Feb
N1  - Accession Number: 105850195. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007264. 
KW  - Cervical Intraepithelial Neoplasia -- Complications
KW  - Cervical Intraepithelial Neoplasia -- Diagnosis
KW  - Cervix Diseases -- Complications
KW  - Cervix Diseases -- Diagnosis
KW  - Cervix Neoplasms -- Complications
KW  - Cervix Neoplasms -- Diagnosis
KW  - HIV Infections -- Complications
KW  - HIV Infections -- Diagnosis
KW  - HIV-1
KW  - Papillomavirus Infections -- Complications
KW  - Papillomavirus Infections -- Diagnosis
KW  - Papillomaviruses -- Classification
KW  - Tumor Virus Infections -- Complications
KW  - Tumor Virus Infections -- Diagnosis
KW  - Antiviral Agents -- Therapeutic Use
KW  - Cervical Intraepithelial Neoplasia -- Epidemiology
KW  - Cervical Intraepithelial Neoplasia -- Therapy
KW  - Cervical Smears
KW  - Cervix Diseases -- Epidemiology
KW  - Cervix Diseases -- Therapy
KW  - Cervix Neoplasms -- Epidemiology
KW  - Cervix Neoplasms -- Therapy
KW  - Colposcopy
KW  - Female
KW  - Health Screening -- Methods
KW  - HIV Infections -- Epidemiology
KW  - HIV Infections -- Therapy
KW  - HIV Infections -- Transmission
KW  - Immune Tolerance
KW  - Papillomavirus Infections -- Epidemiology
KW  - Papillomavirus Infections -- Therapy
KW  - Recurrence
KW  - Risk Factors
KW  - Sensitivity and Specificity
KW  - Tumor Virus Infections -- Epidemiology
KW  - Tumor Virus Infections -- Therapy
KW  - Human
SP  - 86
EP  - 91
JO  - Current Opinion in Obstetrics & Gynecology
JF  - Current Opinion in Obstetrics & Gynecology
JA  - CURR OPIN OBSTET GYNECOL
VL  - 6
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - With heterosexual transmission of HIV becoming the primary mode of transmission to women in the USA, and a high rate of human papillomavirus (HPV) and cervical neoplasia in HIV-infected women, obstetrician-gynecologists have become primary care providers for HIV-infected women. Reports of a high rate of recurrence and progression of cervical neoplasia in this population suggest that gynecologists must strive to identify those women with cervical neoplasia who are HIV infected. Alterations in local immune response of the genital tract caused by HIV infection may be responsible for higher prevalence, recurrence rates, and progression rates of cervical neoplasms in these women. Since cervical cancer may have a more fulminant course in HIV-infected women and has become an AIDS-defining illness, the surveillance and treatment of cervical neoplasia may need to be more aggressive.
SN  - 1040-872X
AD  - Contraceptive Development Branch, Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland.
U2  - PMID: 8180357.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Rodbell, Martin
T1  - Bioinformatics: An Emergine Means of Assessing Environmental Health.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1994/02//
VL  - 102
IS  - 2
M3  - Editorial
SP  - 1
EP  - 1
SN  - 00916765
AB  - Focuses on bioinformatics. Means of assessing environmental health; Biological basis of using bioinformatics; Importance of yeast in bioinformatics research.
KW  - Environmental health
KW  - Bioinformatics
KW  - Computers in biology
KW  - Information science
KW  - Computational biology
KW  - Yeast
N1  - Accession Number: 13013404; Rodbell, Martin 1; Affiliations: 1: National Institute of Environmental Health Sciences.; Issue Info: Feb1994, Vol. 102 Issue 2, p1; Thesaurus Term: Environmental health; Subject Term: Bioinformatics; Subject Term: Computers in biology; Subject Term: Information science; Subject Term: Computational biology; Subject Term: Yeast; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 1p; Document Type: Editorial
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Thorgeirsson, Unnur P.
AU  - Frab, Andrew
AU  - Virmani, Renu
AU  - Adamson, Richard H.
T1  - Cardiac Damage Induced by 2-Amino-3-methylimidazo[4,5-f]quinoline in Nonhuman primates.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1994/02//
VL  - 102
IS  - 2
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Examines the cardiac damage induced by 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in Nonhuman primates. Presence of myocardial lesions among monkeys dosed with IQ; Correlation between dose of IQ and myocardial abnormalities; Evidence for initial stages of IQ-induced toxic cardiomyopathy.
KW  - Quinoline
KW  - Primates
KW  - WOUNDS & injuries
KW  - Toxicology
KW  - Cardiomyopathies
KW  - Heart abnormalities
KW  - Heart
N1  - Accession Number: 13013423; Thorgeirsson, Unnur P. 1; Frab, Andrew 2; Virmani, Renu 2; Adamson, Richard H. 1; Affiliations: 1: Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892 USA; 2: Armed Forces Institute of Pathology, Washington, DC 20306-6000 USA.; Issue Info: Feb1994, Vol. 102 Issue 2, p1; Thesaurus Term: Quinoline; Thesaurus Term: Primates; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Toxicology; Subject Term: Cardiomyopathies; Subject Term: Heart abnormalities; Subject Term: Heart; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Jounaïdi, Youssef
AU  - Bonfils, Claude
AU  - Péin, François
AU  - Negishi, Masahiko
AU  - Lange, Reinhard
T1  - Overexpression of a cytochrome P-450 of the 2a family (Cyp2a-5) in chemically induced hepatomas from female mice.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/02//2/1/94
VL  - 219
IS  - 3
M3  - Article
SP  - 791
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Chemical hepatocarcinogenesis in female mice, induced by 5,9-dimethyl(7H)dibenzo[c,g]carbazole, leads to the overexpression of a cytochrome P-450 of the 2a family. This protein was identified as Cyp2a-5, by the use of immunoblots obtained from isoelectric focusing gels. This method allowed the distinction of Cyp2a-5 from Cyp2a-4, another mouse liver cytochrome P-450, by taking advantage of their slightly different pi values. The theoretical pi values, determined from the amino acid sequence, were pi 9.91 for Cyp2a-4 and pi 10.01 for Cyp2a-5. Other structurally related forms were not detected. In hepatomas from female mice, only the Cyp2a-5 form was overexpressed (23 fold). Male mice showed a weak expression of Cyp2a-4 and Cyp2a-5 in control liver samples and in hepatomas. The expression of both forms was increased more than fivefold upon castration. Pyrazole induces specifically the Cyp2a-5 form. The Cyp2a-5 overexpression was correlated with enhanced microsomal coumarin-7-hydroxylase and testosterone-15a-hydroxylase activities. An immunohistochemical study showed that Cyp2a-4and Cyp2a-5 are expressed uniformly in female livers, but centrilobularly in male livers. In hepatomas, this localisation is perturbed; in females we observed a focal cell localisation, and the Cyp2a-containing cells were often hypertrophic and polyploid. In hepatomas from male mice, the Cyp2a-containing cells became dispersed. From a comparison with other studies, the Cyp2a-5 overexpression appears to be a general feature of hepatocarcinogenesis in mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARCINOGENICITY testing
KW  - ETHANES
KW  - ISOELECTRIC focusing
KW  - PROTEINS
N1  - Accession Number: 11215785; Jounaïdi, Youssef 1 Bonfils, Claude 1 Péin, François 2 Negishi, Masahiko 3 Lange, Reinhard 1; Affiliation:  1: Institut National de  lit Santé et de   Ia Recherche  Médicale, Unité  128,  Montpellier, France.  2: Institut Curie, Orsay, France.  3: National Institute of Environmental Health Sciences, Research Triangle Park, USA.; Source Info: 2/1/94, Vol. 219 Issue 3, p791; Subject Term: CARCINOGENICITY testing; Subject Term: ETHANES; Subject Term: ISOELECTRIC focusing; Subject Term: PROTEINS; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hershberger, Scott L.
AU  - Lichtenstein, Paul
AU  - Knox, Sarah S.
T1  - Genetic and Environmental Influences on Perceptions of Organizational Climate.
JO  - Journal of Applied Psychology
JF  - Journal of Applied Psychology
Y1  - 1994/02//
VL  - 79
IS  - 1
M3  - Article
SP  - 24
EP  - 33
PB  - American Psychological Association
SN  - 00219010
AB  - Genetic and environmental influences on perceptions of organizational climate were assessed by using a 4-group twin design. Data were obtained as part of the Swedish Adoption/Twin Study of Aging. The Work Environment Scale (WES) was used to evaluate perceptions of organizational climate. A measure of job satisfaction was also used to evaluate the effects of genes and environments on job attitudes. Maximum likelihood estimates of genetic and environmental influence suggested significant genetic effects for Supportive Climate--1 factor resulting from a factor analysis of the WES--but not for a second factor, Time Pressure. Significant environmental effects were found for both Supportive Climate and Time Pressure. Genetic effects were not significant for job satisfaction. The relevance of findings to organizational climate research and personnel selection are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Applied Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WORK environment
KW  - JOB satisfaction
KW  - ATTITUDES toward work
KW  - EMPLOYEE selection
KW  - HEREDITY
KW  - TIME pressure
KW  - FACTOR analysis
N1  - Accession Number: 12359353; Hershberger, Scott L. 1; Lichtenstein, Paul 2; Knox, Sarah S. 3; Affiliations: 1: College of Health and Human Development, Pennsylvania State University.; 2: Department of Epidemiology, Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden.; 3: National Heart, Lung, and Blood Institute, Washington, DC.; Issue Info: Feb94, Vol. 79 Issue 1, p24; Thesaurus Term: WORK environment; Thesaurus Term: JOB satisfaction; Thesaurus Term: ATTITUDES toward work; Thesaurus Term: EMPLOYEE selection; Subject Term: HEREDITY; Subject Term: TIME pressure; Subject Term: FACTOR analysis; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107416567
T1  - Tolerability of ketorolac administered via continuous subcutaneous infusion for cancer pain: a preliminary report.
AU  - De Conno F
AU  - Zecca E
AU  - Martini C
AU  - Ripamonti C
AU  - Caraceni A
AU  - Saita L
Y1  - 1994/02//1994 Feb
N1  - Accession Number: 107416567. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836. 
KW  - Cancer Pain -- Drug Therapy
KW  - Ketorolac -- Therapeutic Use
KW  - Ketorolac -- Administration and Dosage
KW  - Infusions, Subcutaneous
KW  - Antiinflammatory Agents, Non-Steroidal
KW  - Evaluation Research
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 119
EP  - 121
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 9
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - We evaluated the local and systemic tolerability of ketorolac administered through continuous subcutaneous infusion in ten cancer patients. The patients were monitored daily for the severity and duration of pain, and the development of other symptoms. The duration of injection site varied from 1 to more than 7 days. No patients complained of local discomfort or pain. Mild local bleeding at the site of drug injection was observed in seven cases. No increase in the intensity of symptoms was observed during the infusion of ketorolac. (Reprinted by permission of Elsevier Science Publishing Co., Inc. Copyright 1994 by the U.S. Cancer Pain Relief Committee)
SN  - 0885-3924
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute, Via Venezian 1, 20123 Milan, Italy
U2  - PMID: 8021534.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107416567&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104786457
T1  - Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study.
AU  - Manolio, T A
AU  - Kronmal, R A
AU  - Burke, G L
AU  - Poirier, V
AU  - O'Leary, D H
AU  - Gardin, J M
AU  - Fried, L P
AU  - Steinberg, E P
AU  - Bryan, R N
Y1  - 1994/02//1994 Feb
N1  - Accession Number: 104786457. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Aged
KW  - Brain -- Pathology
KW  - Cerebrovascular Disorders -- Pathology
KW  - Magnetic Resonance Imaging
KW  - Age Factors
KW  - Aged, 80 and Over
KW  - Analysis of Variance
KW  - Atrophy
KW  - Cerebral Ventricles -- Pathology
KW  - Cerebrovascular Disorders -- Epidemiology
KW  - Female
KW  - Human
KW  - Male
KW  - Regression
KW  - Risk Factors
KW  - Sex Factors
SP  - 318
EP  - 327
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 25
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Background and Purpose: Cerebral magnetic resonance imaging often detects abnormalities whose significance is unknown. The prevalence and correlates of findings such as ventricular enlargement, sulcal widening, and increased white matter signal intensity were examined in 303 men and women aged 65 to 95 years participating in a multicenter study of cardiovascular disease.Methods: Cerebral magnetic resonance imaging was performed and interpreted according to a standard protocol, and findings were correlated with measures of cardiovascular disease and its risk factors.Results: Measures of cerebral atrophy increased with age and were greater in men than in women (each P < .01). Ventricular enlargement and sulcal widening were associated with prior stroke, hypertension, diabetes, and white race (each P < .03). Extent of white matter hyperintensity was associated with age, prior stroke, hypertension, and use of diuretics (each P < .004). On multivariate analysis, age, male gender, white race, and prior stroke retained strong associations with increased ventricular and sulcal scores. After adjustment for age, prior stroke, and other risk factors, white matter hyperintensity was associated with atherosclerosis as measured by increased internal carotid artery thickness on ultrasound.Conclusions: Cerebral atrophy and white matter hyperintensity are common in the elderly and are associated with age, prior stroke, and known cardiovascular risk factors. Though these findings have been suggested to represent normal aging, their wide variability and associations with cardiovascular disease argue against their inevitability with advancing age and support the need to identify modifiable risk factors for these abnormalities.
SN  - 0039-2499
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, MD 20892.
U2  - PMID: 8303738.
DO  - 10.1161/01.STR.25.2.318
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-06481-001
AN  - 2006-06481-001
AU  - Olds, James L.
T1  - Artificial Neural Nets: The Head or Tail of the Dog?
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1994/02//
VL  - 39
IS  - 2
SP  - 127
EP  - 129
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06481-001. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Olds, James L.; Laboratory of Adaptive Systems, National Institutes of Health, Bethesda, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Brain; Cognitive Psychology; Neurosciences. Minor Descriptor: Neural Networks. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Reviewed Item: Churchland, Patricia S.; Sejnowski, Terrence J. The Computational Brain=Cambridge, MA: MIT Press, 1992. 544 pp $39.95; 1992. References Available: Y. Page Count: 3. Issue Publication Date: Feb, 1994. 
AB  - Reviews the book, The Computational Brain by Patricia S. Churchland and Terrence J. Sejnowski (1992). The authors are doing nothing less than making a case for how neuroscience should proceed in the future. Sejnowski and Churchland believe that the nascent field of computational neuroscience should lead the way, ideally with computational models leading to new wet-lab experiments, subsequently leading to new and better computational models Given the overwhelming diversity and quantity of the raw data being produced by neuroscientists on a weekly basis (to say nothing of the quality), their agenda makes a lot of sense. The Computational Brain represents a major effort to bring together the fields of neurophilosophy and neural networks into one comprehensive tome. The seven chapters and Appendix that make up the book are structured in such a way as to lead the reader from an overview of classical neuroscience through the basics of artificial neural networks. From those basics, Churchland and Sejnowski proceed to deal sequentially with perception, memory formation, motor integration, and their summing up in a conclusions chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - computational neuroscience
KW  - brain
KW  - 1994
KW  - Brain
KW  - Cognitive Psychology
KW  - Neurosciences
KW  - Neural Networks
KW  - 1994
U2  - Churchland, Patricia S.; Sejnowski, Terrence J. (1992); The Computational Brain; Cambridge, MA: MIT Press, 1992. 544 pp $39.95; 0-262-03188-4.
DO  - 10.1037/033873
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36260-007
AN  - 2015-36260-007
AU  - Newton, Dianne L.
AU  - Walbridge, Stuart
AU  - Mikulski, Stanislaw M.
AU  - Ardelt, Wojciech
AU  - Shogen, Kuslima
AU  - Ackerman, Steven J.
AU  - Rybak, Susanna M.
AU  - Youle, Richard J.
T1  - Toxicity of an antitumor ribonuclease to Purkinje neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/02//
VL  - 14
IS  - 2
SP  - 538
EP  - 544
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Newton, Dianne L., Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 10, Room 5D37, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36260-007. PMID: 8301353 Partial author list: First Author & Affiliation: Newton, Dianne L.; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ackerman, Steven J. Major Descriptor: Neurons; Neurotoxins; Purkinje Cells. Minor Descriptor: Guinea Pigs. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 7. Issue Publication Date: Feb, 1994. Publication History: Accepted Date: Jun 30, 1993; Revised Date: Jun 25, 1993; First Submitted Date: Dec 21, 1992. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Purkinje cell toxicity is one of the characteristic features of the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis, and tremor that may lead to death (Gordon, 1933). Two members of the RNase superfamily found in humans, EDN (eosinophil- derived neurotoxin) and ECP (eosinophil cationic protein), cause the Gordon phenomenon when injected intraventricularly into guinea pigs or rabbits. We have found that another member of the RNase superfamily, an antitumor protein called onconase, isolated from Rana pipiens oocytes and early embryos, will also cause the Gordon phenomenon when injected into the cerebrospinal fluid of guinea pigs at a dose similar to that of EDN (LD₅₀, 3–4 μg). Neurologic abnormalities of onconase- treated animals were indistinguishable from those of EDN-treated animals, and histology showed dramatic Purkinje cell loss in the brains of onconase-treated animals. The neurotoxic activity of onconase correlates with ribonuclease activity. Onconase modified by iodoacetic acid to eliminate 70% and 98% of the ribonuclease activity of the native enzyme displays a similar decrease in ability to cause the Gordon phenomenon. In contrast, the homologous bovine pancreatic RNase A injected intraventricularly at a dose 5000 times greater than the LD₅₀ dose of EDN or onconase is not toxic and does not cause the Gordon phenomenon. A comparison of the RNase activities of EDN, onconase, and bovine pancreatic RNase A using three pancreatic RNA substrates demonstrates that onconase is orders of magnitude less active enzymatically than EDN and RNase A. Thus, another member of the RNase superfamily in addition to EDN and ECP can cause the Gordon phenomenon. onconase-mediated neurotoxicity. However, substantial differences in neurotoxicity observed among some homologous ribonucleases cannot be due to their different enzymatic activities; other features of the enzymes are considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - eosinophil-derived neurotoxin (EDN)
KW  - onconase
KW  - ribonucleases
KW  - RNase A
KW  - Purkinje cells
KW  - Gordon phenomenon
KW  - 1994
KW  - Neurons
KW  - Neurotoxins
KW  - Purkinje Cells
KW  - Guinea Pigs
KW  - 1994
U1  - Sponsor: National Institutes of Health, US. Grant: AI22660; AI25230. Recipients: Ackerman, Steven J.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36260-015
AN  - 2015-36260-015
AU  - Petralia, R. S.
AU  - Yokotani, N.
AU  - Wenthold, R. J.
T1  - Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/02//
VL  - 14
IS  - 2
SP  - 667
EP  - 696
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Petralia, R. S., Laboratory of Neurochemistry, NIDCD, NIH, Building 36, Room 5D-08, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36260-015. PMID: 8301357 Partial author list: First Author & Affiliation: Petralia, R. S.; Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amino Acids; Cerebellum; Hippocampus; Immunocytochemistry. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 30. Issue Publication Date: Feb, 1994. Publication History: Accepted Date: Jul 22, 1993; Revised Date: Jul 13, 1993; First Submitted Date: May 25, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - NMDA receptors play key roles in synaptic plasticity and neuronal development, and may be involved in learning, memory, and compensation following injury. A polyclonal antibody that recognizes four of seven splice variants of NMDAR1 was made using a C-terminus peptide (30 amino acid residues). NMDAR1 is the major NMDA receptor subunit, found in most or all NMDA receptor complexes. On immunoblots, this antibody labeled a single major band migrating at Mr = 120,000. The antibody did not cross-react with extracts from transfected cells expressing other glutamate receptor subunits, nor did it label non-neuronal tissues. Immunostained vibratome sections of rat tissue showed labeling in many neurons in most structures in the brain, as well as in the cervical spinal cord, dorsal root and vestibular ganglia, and in pineal and pituitary glands. Staining was moderate to dense in the olfactory bulb, neocortex, striatum, some thalamic and hypothalamic nuclei, the colliculi, and many reticular, sensory, and motor neurons of the brainstem and spinal cord. The densest stained cells included the pyramidal and hilar neurons of the CA3 region of the hippocampus, Purkinje cells of the cerebellum, supraoptic and magnocellular paraventricular neurons of the hypothalamus, inferior olive, red nucleus, lateral reticular nucleus, peripheral dorsal cochlear nucleus, and motor nuclei of the lower brainstem and spinal cord. Ultrastructural localization of immunostaining was examined in the hippocampus, cerebral cortex, and cerebellar cortex. The major staining was in postsynaptic densities apposed by unstained presynaptic terminals with round or mainly round vesicles, and in associated dendrites. The pattern of staining matched that of previous in situ hybridization but differed somewhat from that of binding studies, implying that multiple types of NMDA receptors exist. Comparison with previous studies of localization of other glutamate receptor types revealed that NMDAR1 may colocalize with these other types in many neurons throughout the nervous system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - excitatory amino acids
KW  - ultrastructure
KW  - immunocytochemistry
KW  - AMPA
KW  - hippocampus
KW  - cerebellum
KW  - 1994
KW  - Amino Acids
KW  - Cerebellum
KW  - Hippocampus
KW  - Immunocytochemistry
KW  - Rats
KW  - 1994
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - De Luca, Luigi M.
AU  - Darwiche, Nadine
AU  - Celli, Giulia
AU  - Kosa, Karolina
AU  - Jones, Carol
AU  - Ross, Sharon
AU  - Li-Chuan Chen
T1  - Vitamin A in Epithelial Differentiation and Skin Carcinogenesis.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1994/02/02/Feb94 Part 2
VL  - 52
IS  - 2
M3  - Article
SP  - S45
EP  - S52
SN  - 00296643
AB  - The article examines vitamin A and focuses on its role in epithelial cell differentiation and skin carcinogenesis. According to the article, retinoic acid is needed for the maintenance of certain phenotypes. Furthermore, it is said that dietary retinoids are essential for replacing squamous metaplastic lesions with normal columnar epithelial cells. The article discusses retinoic acid receptor expression, the role of retinoic acid as a chemopreventive agent, and the role of dietary retinoic acid in inhibiting the transformation of benign lesion papilloma to carcinoma.
KW  - VITAMIN A
KW  - RESEARCH
KW  - CHEMOPREVENTION
KW  - CARCINOGENESIS
KW  - PREVENTION
KW  - TRETINOIN
KW  - PHENOTYPE
KW  - PAPILLOMA
KW  - EPITHELIAL cells
KW  - CELL differentiation
N1  - Accession Number: 26019413; De Luca, Luigi M. 1 Darwiche, Nadine 2 Celli, Giulia 3 Kosa, Karolina 2 Jones, Carol 3 Ross, Sharon 2 Li-Chuan Chen 2; Affiliation:  1: Section Chief, Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  2: Postdoctoral Fellow, Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  3: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Feb94 Part 2, Vol. 52 Issue 2, pS45; Subject Term: VITAMIN A; Subject Term: RESEARCH; Subject Term: CHEMOPREVENTION; Subject Term: CARCINOGENESIS; Subject Term: PREVENTION; Subject Term: TRETINOIN; Subject Term: PHENOTYPE; Subject Term: PAPILLOMA; Subject Term: EPITHELIAL cells; Subject Term: CELL differentiation; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Smet, Marc De
T1  - Practical Atlas of Retinal Disease and Therapy (Book).
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1994/02/15/
VL  - 120
IS  - 4
M3  - Book Review
SP  - 349
EP  - 349
SN  - 00034819
AB  - Reviews the book 'Practical Atlas of Retinal Disease and Therapy,' by William R. Freeman.
KW  - RETINAL diseases
KW  - NONFICTION
KW  - FREEMAN, William
KW  - PRACTICAL Atlas of Retinal Disease & Therapy (Book)
N1  - Accession Number: 6987451; Smet, Marc De 1; Affiliation:  1: National Eye Institute, Bethesda; Source Info: 2/15/94, Vol. 120 Issue 4, p349; Subject Term: RETINAL diseases; Subject Term: NONFICTION; Reviews & Products: PRACTICAL Atlas of Retinal Disease & Therapy (Book); People: FREEMAN, William; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 388
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104784998
T1  - Prevalence of tobacco smoking among junior high school students in Japan and background life style of smokers.
AU  - Wada, K
AU  - Fukui, S
Y1  - 1994/03//
N1  - Accession Number: 104784998. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Adolescence
KW  - Ethnological Research
KW  - Life Style
KW  - Smoking -- Epidemiology
KW  - Attitude to Health
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Incidence
KW  - Japan
KW  - Male
KW  - Smoking -- Ethnology
KW  - Smoking -- Prevention and Control
KW  - Social Environment
SP  - 331
EP  - 343
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 89
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - In order to estimate the prevalence of tobacco smoking among junior high school students in Japan and to assess certain characteristics of smokers, the authors surveyed 5240 students aged between 12 and 15 years. In terms of both the number of subjects and of schools, this was the first major survey of Japanese junior high schools on the relationship between tobacco smoking and the background life styles of smokers. Of all students, 30.5% of males, 13.3% of females and 22.2% of the total were lifetime smokers; 3.3%, 0.8% and 2.2%, respectively, were daily smokers. As the frequency of tobacco smoking increased, the regularity of the life style routine was significantly more disturbed, and school and family life were significantly less relaxed. The authors suggest that the strengthening of family cohesion would be an effective preventive strategy in Japan.
SN  - 0965-2140
AD  - Division of Drug Dependence and Psychotropic Drug Clinical Research, National Institute of Mental Health, Chiba-ken, Japan.
U2  - PMID: 8173503.
DO  - 10.1111/j.1360-0443.1994.tb00900.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104784999
T1  - Consumption indicators of alcohol dependence.
AU  - Dawson, D A
Y1  - 1994/03//
N1  - Accession Number: 104784999. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcoholism -- Epidemiology
KW  - Health Screening
KW  - Alcohol Drinking
KW  - Alcohol Drinking -- Epidemiology
KW  - Alcohol Withdrawal Delirium -- Classification
KW  - Alcohol Withdrawal Delirium -- Diagnosis
KW  - Alcohol Withdrawal Delirium -- Epidemiology
KW  - Alcoholic Beverages
KW  - Alcoholism -- Classification
KW  - Alcoholism -- Diagnosis
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Incidence
KW  - Interview Guides
KW  - Male
KW  - Psychological Tests
KW  - Sex Factors
KW  - Surveys
KW  - United States
SP  - 345
EP  - 350
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 89
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This Data Note evaluates various dichotomous measures of alcohol consumption as screeners for past-year alcohol dependence. The analysis is based on data from 22,102 current drinkers interviewed in the 1988 US National Health Interview Survey. The consumption indicators include measures of average daily intake, frequency of heavy drinking, usual quantity and frequency of drinking and various combinations of these measures. The measures based on frequency of heavy drinking are the most strongly correlated with dependence, but none of the consumption indicators have the sensitivity or specificity of screeners based on alcohol-related problems. Most of the consumption items considered in this analysis screen for dependence more successfully among men than among women.
SN  - 0965-2140
AD  - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20892.
U2  - PMID: 8173504.
DO  - 10.1111/j.1360-0443.1994.tb00901.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Specker, Bonny L.
AU  - Vieira, Nancy E.
AU  - O'Brien, Kimberly O.
AU  - Ho, Mona L.
AU  - Heubi, James E.
AU  - Abrams, Steven A.
AU  - Yergey, Alfred L.
T1  - Calcium kinetics in lactating women with low and high calcium intakes.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/03//
VL  - 59
IS  - 3
M3  - Article
SP  - 593
EP  - 599
SN  - 00029165
AB  - Absorption of calcium and its mobilization from bone during lactation are important for delivery of calcium to breast-feeding infants; whether calcium intake offsets bone resorption is not known. We hypothesized that calcium absorption is increased in lactation and greater in women on low calcium diets, resulting in similar rates of bone resorption and accretion. Calcium absorption and kinetic indexes were calculated by using two stable isotopic tracers in 8 women; 6 were studied both during lactation and nonlactation. Women consumed low calcium diets, with half receiving supplemental calcium. Intestinal absorption was related to serum 1,25-dihydroxyvitamin D and did not increase during lactation. Despite decreased urinary calcium excretion during lactation, especially in women with low calcium intake, net balance tended to be lower during lactation. Mean residence time decreased and bone resorption exceeded accretion in almost all lactating women. Calcium need for milk production appears to be met by decreased urinary excretion and increased bone resorption, and not by increased intestinal absorption. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Food consumption
KW  - HEALTH
KW  - Calcium in human nutrition
KW  - Intestinal absorption
KW  - Women
KW  - Bone density
KW  - Lactation
KW  - bone
KW  - calcium
KW  - intestinal absorption
N1  - Accession Number: 94426842; Specker, Bonny L. 1,2,3; Vieira, Nancy E. 1,2,3; O'Brien, Kimberly O. 1,2,3; Ho, Mona L. 1,2,3; Heubi, James E. 1,2,3; Abrams, Steven A. 1,2,3; Yergey, Alfred L. 1,2,3; Affiliations: 1: Department of Pediatrics, University of Cincinnati Medical Center and Children's Hospital Medical Center, Cincinnati; 2: National Institute of Child Health and Human Development, Bethesda, MD; 3: Department of Pediatrics, Baylor Medical Center and USDA/ARS Children's Nutrition Research Center, Houston; Issue Info: Mar1994, Vol. 59 Issue 3, p593; Thesaurus Term: Food consumption; Thesaurus Term: HEALTH; Subject Term: Calcium in human nutrition; Subject Term: Intestinal absorption; Subject Term: Women; Subject Term: Bone density; Subject Term: Lactation; Author-Supplied Keyword: bone; Author-Supplied Keyword: calcium; Author-Supplied Keyword: intestinal absorption; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Briggs, Nathaniel C.
AU  - Jefferson, James W.
T1  - Letter to the Editor.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1994/03//
VL  - 20
IS  - 1
M3  - Letter
SP  - 125
EP  - 125
SN  - 00952990
AB  - Presents a letter to the editor about the abuse of monoamine oxidase inhibitors.
KW  - LETTERS to the editor
KW  - MONOAMINE oxidase inhibitors
N1  - Accession Number: 18175997; Briggs, Nathaniel C. 1 Jefferson, James W. 2; Affiliation:  1: National Institute of Mental Health, Laboratory of Clinical Science, Section on Clinical Neuropharmacology, NIH Clinical Center, 10-3D41, Bethesda, Maryland 20892.  2: Dean Foundation, 800 Excelsior Drive, Madison, Wisconsin 53717-1914.; Source Info: 1994, Vol. 20 Issue 1, p125; Subject Term: LETTERS to the editor; Subject Term: MONOAMINE oxidase inhibitors; Number of Pages: 1p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Suomi, Stephen J.
T1  - Hierarchical Complexity of Combinatorial Manipulation in Capuchin Monkeys (Cebus apella).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1994/03//
VL  - 32
IS  - 3
M3  - Article
SP  - 171
EP  - 176
SN  - 02752565
AB  - The purpose of this study was to examine the hierarchical complexity of combinatorial manipulation in capuchin monkeys Cebus apella). Two experiments were conducted. In Experiment 1 capuchins were presented with an apparatus designed to accommodate the use of probing tools. In Experiment 2 the same capuchins were presented with sets of nesting containers. Five of the ten subjects used probing tooth and seven subjects placed objects in the containers. The capuchins' behavior reflected three hierarchically organized combinatorial patterns displayed by chimpanzees and human infants. Although the capuchins sometimes displayed the two more complex patterns ("pot" and "subassembly"), their combinatorial behavior was dominated by the simplest pattern ("pairing"). In this regard capuchins may not attain the same grammar of manipulative action that has been reported for chimpanzees and young human children. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CEBUS apella
KW  - SOCIAL hierarchy in animals
KW  - SOCIAL behavior in animals
KW  - PRIMATE behavior
KW  - ANIMAL behavior
KW  - CAPUCHIN monkeys
N1  - Accession Number: 12329831; Westergaard, Gregory Charles 1 Suomi, Stephen J. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Poolesville, Maryland.; Source Info: 1994, Vol. 32 Issue 3, p171; Subject Term: CEBUS apella; Subject Term: SOCIAL hierarchy in animals; Subject Term: SOCIAL behavior in animals; Subject Term: PRIMATE behavior; Subject Term: ANIMAL behavior; Subject Term: CAPUCHIN monkeys; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Subar, Amy F.
AU  - Ziegler, Regina G.
AU  - Patterson, Blossom H.
AU  - Ursin, Giske
AU  - Graubard, Barry
T1  - US Dietary Patterns Associated with Fat Intake: The 1987 National Health Interview Survey.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/03//
VL  - 84
IS  - 3
M3  - Article
SP  - 359
EP  - 366
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This research used food frequency data to investigate dietary patterns associated with fat intake. Methods. Data from the 1987 National Health Interview Survey of 20143 adults were used to determine correlations between fat (adjusted for kilocalories) and both nutrient and food group intakes. Median food and nutrient intakes were determined within quartiles of percentage of kilocalories from fat. Results. Intakes of vegetables, fruits, cereals, fish/chicken, low-fat milk, alcoholic beverages, vitamin C, percentage of kilocalories from carbohydrates, carotenoids, folate, dietary fiber, carbohydrates, and vitamin A decreased as percentage of kilocalories from fat increased. Intakes of salty snacks, peanuts, processed and red meats, whole milk and cheese, desserts, eggs, fried potatoes, table fats, cholesterol, vitamin E, sodium, protein, and energy increased with percentage of kilocalories from fat. Results by demographic subgroups showed few differences from those found in the total population. Conclusions. Fat intake is consistently associated with specific dietary patterns. Such patterns need to be evaluated concurrently in studies of diet and chronic disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIET
KW  - FOOD -- Fat content
KW  - INGESTION
KW  - NUTRITION
KW  - UNITED States
N1  - Accession Number: 9406150681; Subar, Amy F. 1 Ziegler, Regina G. 2 Patterson, Blossom H. 1 Ursin, Giske 3 Graubard, Barry 1; Affiliation:  1: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.  2: Division of Cancer Etiology, National Cancer Institute  3: Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles; Source Info: Mar1994, Vol. 84 Issue 3, p359; Subject Term: DIET; Subject Term: FOOD -- Fat content; Subject Term: INGESTION; Subject Term: NUTRITION; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chen, Yung-Cheng Joseph
AU  - Yu, Mei-Lin M.
AU  - Rogan, Walter J.
AU  - Gladen, Beth C.
AU  - Chen-Chin Hsu
T1  - A 6-Year Follow-up of Behavior and Activity Disorders in the Taiwan Yu-cheng Children.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/03//
VL  - 84
IS  - 3
M3  - Article
SP  - 415
EP  - 421
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The relationship of behavior and activity levels to the interval between outbreak and year of birth and to age of the children is explored in Taiwanese children exposed in utero to heat-degraded polychlorinated biphenyls (PCBs)--the Yu-cheng children. Additionally, the relationship of the scores to chemical, physical, and cognitive findings is described. Methods. With Rutter's Child Behavior Scale A and a modified Werry-Weiss-Peters Activity Scale, 118 Yu-cheng children and matched controls were followed biannually from 1985 to 1991. Results. At each year, the Yucheng children scored 7% to 43% worse (mean = 23%) than control children on the Rutter scale. At any fixed age, the Yu-cheng children scored 11% to 63% (mean = 28%) worse. The effect for children born later did not differ from that for those born earlier; neither was there any improvement as the children aged. A similar but weaker picture was seen for the activity score. These behavioral findings were not related to physical or cognitive findings or to serum PCB levels. Conclusions. In utero exposure to heat-degraded PCBs appears to cause mildly disordered behavior and increased activity level; the effect persists over time and is similar in children born up to 6 years after the mothers were exposed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BEHAVIOR disorders in children
KW  - POLYCHLORINATED biphenyls
KW  - PERSONALITY tests for children
KW  - BEHAVIOR disorders
KW  - TAIWAN
N1  - Accession Number: 9406150690; Chen, Yung-Cheng Joseph 1 Yu, Mei-Lin M. 2 Rogan, Walter J. 2 Gladen, Beth C. 2 Chen-Chin Hsu 1; Affiliation:  1: Department of Psychiatry, National Cheng Kung University Medical College, Tainan, Taiwan  2: Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC; Source Info: Mar1994, Vol. 84 Issue 3, p415; Subject Term: BEHAVIOR disorders in children; Subject Term: POLYCHLORINATED biphenyls; Subject Term: PERSONALITY tests for children; Subject Term: BEHAVIOR disorders; Subject Term: TAIWAN; Number of Pages: 7p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lynch, Charles F.
AU  - Logsden-Sackett, Nyla
AU  - Edwards, Sandra L.
AU  - Cantor, Kenneth P.
T1  - The Driver's License List as a Population-Based Sampling Frame in Iowa.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/03//
VL  - 84
IS  - 3
M3  - Article
SP  - 469
EP  - 472
PB  - American Public Health Association
SN  - 00900036
AB  - Driver's license lists are infrequently used for population-based sampling, presumably because of suspicions of poor population coverage. The 1990 Iowa driver's license list was compared with the 1990 census to evaluate coverage by 5-year age group, sex, resident county, and urbanicity. Coverage exceeded 90% among 15- to 74-year-old men and 15- to 64-year-old women, with uniform coverage by county and county urbanicity group in these age ranges. In Iowa, these lists are convenient and cost-effective and appear to be representative for 25- to 64-year-olds. The representativeness of driver lists in regard to other factors and in other geographic regions deserves further evaluation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRIVERS' licenses
KW  - POPULATION
KW  - DEMOGRAPHIC surveys
KW  - SAMPLING (Statistics)
KW  - IOWA
N1  - Accession Number: 9406150701; Lynch, Charles F. 1 Logsden-Sackett, Nyla 1 Edwards, Sandra L. 2 Cantor, Kenneth P. 3; Affiliation:  1: Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City, Md.  2: Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Md.  3: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Md.; Source Info: Mar1994, Vol. 84 Issue 3, p469; Subject Term: DRIVERS' licenses; Subject Term: POPULATION; Subject Term: DEMOGRAPHIC surveys; Subject Term: SAMPLING (Statistics); Subject Term: IOWA; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 926120 Regulation and Administration of Transportation Programs; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Susan Zelitch Yanovski
AU  - Sebring, Nancy G.
T1  - Recorded Food Intake of Obese Women with Binge Eating Disorder Before and After Weight Loss.
JO  - International Journal of Eating Disorders
JF  - International Journal of Eating Disorders
Y1  - 1994/03//
VL  - 15
IS  - 2
M3  - Article
SP  - 135
EP  - 150
PB  - John Wiley & Sons, Inc.
SN  - 02763478
AB  - Because binge eating in obese individuals has been postulated to be a reaction to dietary restriction, we examined the recorded food intake of 17 obese women with and 16 obese women without binge eating disorder (BED) during 1-week periods before and 3 months after a very low calorie diet program in order to determine the effects of dietary restriction on binge eating frequency and severity. Before weight loss, rather than reporting severe caloric restriction, women with BED reported greater average energy intake than nonbinge eaters on both a total (2707 vs. 1869 kcal/day, p < .01) and weight-adjusted (25.1 vs. 18.1 kcal/day, p <.01) basis, with both higher intake on nonbinge days and an increased frequency of binge days. After weight loss, there was no significant difference energy intake, on either a total or weight-adjusted basis, between subjects with and without BED. Although average daily energy intake fell for both groups after weigh loss, only subjects with BED reported significantly decreased energy intake when adjusted for change in body weight. This resulted from decreased intake on nonbinge days and a decreased frequency of binge days. Before weight loss, subjects with BED reported an average energy intake equivalent to 94% of their predicted energy expenditure. Whereas subjects without BED reported intake only 64% of predicted (p = .002). After weight loss, there was no significant difference between subjects with and without BED in the percentage of predicted energy expenditure reported as intake (64% vs. 58%). Restraint was similar in both groups before weight loss, but those with BED reported greater hunger and disinhibition. After weight losstreatment, restraint increased significantly, whereas disinhibition and hunger remained elevated in subjects with BED. Disinhibition, rather than restraint, appears to be a major contributor to the disordered eating of these individuals. Unlike normal-weight women with bulimia nervosa, dietary restriction does not appear to worsen symptoms of binge eating in obese women with BED. Over the short term, subjects with BED nay respond to a standard weight loss treatment program with improvements in binge eating behaviors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPULSIVE eating
KW  - WOMEN
KW  - BODY weight
KW  - DIET
KW  - BEHAVIOR
N1  - Accession Number: 11919081; Susan Zelitch Yanovski 1 Sebring, Nancy G. 2; Affiliation:  1: Special Expert, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases and Guest Researcher, Clinical Neuroendocrinology Branch, National Institute of Mental Health  2: Nutrition Research Specialist, Clinical Center Nurtrition Service, National Institutes of Health, Bethesda, MD; Source Info: Mar1994, Vol. 15 Issue 2, p135; Subject Term: COMPULSIVE eating; Subject Term: WOMEN; Subject Term: BODY weight; Subject Term: DIET; Subject Term: BEHAVIOR; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Osterhoff, Birgit
AU  - Rappersberger, Klemens
AU  - Binghe Wang
AU  - Koszik, Frieder
AU  - Ochiai, Kenichi
AU  - Kinet, Jean-Pierre
AU  - Stingl, Georg
T1  - Immunomorphologic Characterization of Fc∈RI-Bearing Cells Within the Human Dermis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/03//
VL  - 102
IS  - 3
M3  - Article
SP  - 315
EP  - 320
SN  - 0022202X
AB  - Recently we reported that the high-affinity receptor for IgE, Fc&epsiv;RI, is constitutively expressed on normal epidermal Langerhans cells (LC) and on certain cells within the dermis. To study the nature of these cells we performed immunofluorescence double-labeling experiments using an anti-Fc&epsiv;RI reagent (MoAb 15-1) as well as monoclonal antibodies (MoAb) against leukocyte differentiation antigens expressed on LC, interdigitating cells and macrophages. Avidin-fluorescein isothiocyanate was used to distinguish mast cells. We found that dermal Fc&epsiv;RI+ cells are bone marrow derived (CD45+). Further, we found that a subset of 15-1+ dermal cells coexpresses antigens present on certain members of the LC/DC family: the majority of Fc&epsiv;RI+ cells reacted with MoAb anti-HLA-DR and RFD1, the latter recognizes an antigenic moiety on interdigitating cells, and a small sub-population coexpressed CD1a. In reverse fashion, virtually all CD1a+ cells and most RFD1+ cells reacted with the anti-Fc&epsiv;RI reagent. Approximately one third of 15-P cells represented avidin-FITC+ mast cells whereas Fc&epsiv;RI expression was not detected on FXIIIa+ dermal dendrocytes or CD3+ lymphocytes. By immunoelectronmicroscopy, we found that perivascularly located 15-1-reactive cells exhibited pronounced dendrites, an indented nucleus, numerous mitochondria, and abundant endo-/lysosomal structures. However, Birbeck granules or granules specific for basophils or eosinophils were never detected in these cells. Collectively, our data suggest that the pool of dermal Fc&epsiv;RI+ cells consists mainly of cells of the LC (CD1a+)/ DC(RFD1+ lineage and mast cells but does not include FXIIIa+ dermal macrophages. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DERMIS
KW  - LANGERHANS cells
KW  - IMMUNOFLUORESCENCE
KW  - IMMUNOGLOBULINS
KW  - LEUCOCYTES
KW  - MAST cells
N1  - Accession Number: 12371789; Osterhoff, Birgit 1 Rappersberger, Klemens 2 Binghe Wang 1 Koszik, Frieder 1 Ochiai, Kenichi 3 Kinet, Jean-Pierre 3 Stingl, Georg 1; Affiliation:  1: Department of Dermatology, Division of Immunology, Allergy & Infectious Diseases, University of Vienna Medical School and Vienna International Research Cooperation Center (VIRCC), Vienna, Austria.  2: Division of General Dermatology, University of Vienna Medical School and Vienna International Research Cooperation Center (VIRCC), Vienna, Austria.  3: Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, U.S.A..; Source Info: Mar1994, Vol. 102 Issue 3, p315; Subject Term: DERMIS; Subject Term: LANGERHANS cells; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNOGLOBULINS; Subject Term: LEUCOCYTES; Subject Term: MAST cells; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371789
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12371789&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moshell, Alan N.
AU  - DiGiovanna, John J.
AU  - Bale, Sherri J.
T1  - Epidermolytic Hyperkeratosis: Applied Molecular Genetics.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/03//
VL  - 102
IS  - 3
M3  - Article
SP  - 390
EP  - 394
SN  - 0022202X
AB  - Epidermolytic hyperkeratosis is an autosomal dominant ichthyosis characterized by blistering, especially at birth and during childhood, and hyperkeratosis. Epidermolytic hyperkeratosis presents striking clinical heterogeneity, particularly between families. Several avenues of research have implicated an abnormality of epidermal differentiation in the pathogenesis of this disease. In a three-generation family with 20 affected individuals, we tested a variety of candidate loci and identified linkage to the type II keratin region on chromosome 12. Further investigation revealed a mutation in the H1 subdomain of the keratin 1 gene as the cause of EHK in this family. Because keratin 10 is the co-expressed partner of keratin 1, it was not surprising when abnormalities in keratin 10 were found in other families with EHK. We have examined 52 patients from 21 families and have identified at least six clinical phenotypes. The most useful distinguishing feature was the presence or absence of severe hyper keratosis of the palms and soles. We and others are continuing to search for and characterize mutations in keratin 1 and 10 in patients with epidermolytic hyperkeratosis. Correlation of the clinical disease types with the specific mutations should lead to a better understanding of the relationship between keratin structure and function in normal and diseased epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ICHTHYOSIS
KW  - KERATIN
KW  - MOLECULAR genetics
KW  - HETEROGENEITY
KW  - EPIDERMIS -- Diseases
KW  - CHROMOSOME abnormalities
KW  - <em>genodermatosis</em>
KW  - <em>ichthyosis</em>
KW  - <em>keratin</em>
N1  - Accession Number: 12371801; Moshell, Alan N. DiGiovanna, John J. 1 Bale, Sherri J. 2; Affiliation:  1: Dermatology Branch, Division of Cancer Biology, Diagnosis and Centers, National Cancer Institute.  2: Genetic Studies Section, Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, Maryland, U.S.A..; Source Info: Mar1994, Vol. 102 Issue 3, p390; Subject Term: ICHTHYOSIS; Subject Term: KERATIN; Subject Term: MOLECULAR genetics; Subject Term: HETEROGENEITY; Subject Term: EPIDERMIS -- Diseases; Subject Term: CHROMOSOME abnormalities; Author-Supplied Keyword: <em>genodermatosis</em>; Author-Supplied Keyword: <em>ichthyosis</em>; Author-Supplied Keyword: <em>keratin</em>; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12371801
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12371801&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107413956
T1  - Association of visual impairment with mobility and physical function.
AU  - Salive ME
AU  - Guralnik J
AU  - Glynn RJ
AU  - Christen W
AU  - Wallace RB
AU  - Ostfeld AM
Y1  - 1994/03//3/ 1/1994
N1  - Accession Number: 107413956. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by the National Institute on Aging, through contracts NO1-AG-02105, N01-AG-02106 and N01-AG-0267. NLM UID: 7503062. 
KW  - Vision Disorders -- In Old Age
KW  - Physical Mobility -- In Old Age
KW  - Funding Source
KW  - Vision Disorders -- Diagnosis
KW  - Vision Tests
KW  - Cross Sectional Studies
KW  - Prospective Studies
KW  - Interviews
KW  - Logistic Regression
KW  - Aged
KW  - Outpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 287
EP  - 292
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8120313.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107413956&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107421016
T1  - The Vulpe Assessment Battery and the Peabody Developmental Motor Scales: a preliminary study of concurrent validity between gross motor sections.
AU  - Jain M
AU  - Turner D
AU  - Worrell T
Y1  - 1994/03//
N1  - Accession Number: 107421016. Language: English. Entry Date: 19950901. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Peabody Developmental Motor Scales (PDMS-GM); Vulpe Assessment Battery for the Atypical Handicapped Child (VAB-GM). NLM UID: 8109120. 
KW  - Concurrent Validity -- Evaluation
KW  - Clinical Assessment Tools
KW  - Child, Disabled -- Evaluation
KW  - Child, Preschool -- Evaluation
KW  - Pearson's Correlation Coefficient
KW  - Convenience Sample
KW  - Intrarater Reliability
KW  - Reliability
KW  - Descriptive Statistics
KW  - Pilot Studies
KW  - Child Development
KW  - Infant
KW  - Child, Preschool
KW  - Human
SP  - 23
EP  - 33
JO  - Physical & Occupational Therapy in Pediatrics
JF  - Physical & Occupational Therapy in Pediatrics
JA  - PHYS OCCUP THER PEDIATR
VL  - 14
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - The purpose of this study was to determine concurrent validity of the gross motor sections (GM) of the Vulpe Assessment Battery for the Atypical Handicapped Child (VAB) as compared to the Peabody Development Motor Scales (PDMS). Prior to assessing concurrent validity, intra-rater reliability was established on the PDMS-GM and the VAB-GM, by testing eight children from a community preschool and a developmental preschool, respectively. Intraclass correlation coefficient (ICC 1,1) of the ceiling scores revealed an intra-rater reliability of .99 and .87 on the PDMS-GM and the VAB-GM respectively. Concurrent validity was determined by testing 13 children with disability on the VAB-GM and the PDMS-GM. The ceiling scores were analyzed using the Pearson Product Moment Correlation Coefficient. Concurrent validity was high (r = .97) and strong agreement between the VAB-GM and PDMS-GM was noted. The VAB-GM provides useful quantitative information to therapists and families on the specific manner of task performance during developmental assessment in children with disabilities.
SN  - 0194-2638
AD  - Dept of Rehabilitation Medicine, National Institutes of Health, Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107421016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104784581
T1  - Reduction of functional neuronal connectivity in long-term treated hypertension.
AU  - Mentis, M J
AU  - Salerno, J
AU  - Horwitz, B
AU  - Grady, C
AU  - Schapiro, M B
AU  - Murphy, D G
AU  - Rapoport, S I
Y1  - 1994/03//1994 Mar
N1  - Accession Number: 104784581. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266. 
KW  - Brain -- Physiopathology
KW  - Hypertension -- Physiopathology
KW  - Aged
KW  - Aged, 80 and Over
KW  - Blood Pressure -- Physiology
KW  - Brain -- Blood Supply
KW  - Brain -- Radiography
KW  - Cerebral Arteries -- Physiopathology
KW  - Male
KW  - Middle Age
KW  - Time Factors
KW  - Tomography, Emission-Computed
SP  - 601
EP  - 607
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 25
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Background and Purpose: Anatomic imaging of patients with chronic well-treated hypertension has demonstrated dilatation of the lateral cerebral ventricles and left brain atrophy, whereas positron emission tomography has shown only subtle reductions in regional cerebral metabolic rates for glucose in some subcortical nuclei. To further explore the implications of the imaging changes, an analytic technique designed to determine functional neuronal connectivity between regions of interest (ROIs) was applied to the data on regional cerebral metabolic rates for glucose to determine if and where in the brain reduction of functional neuronal connectivity occurred.Methods: Glucose metabolism was measured by positron emission tomography in 17 older men (age, 68 +/- 8 years) with well-controlled, noncomplicated hypertension of at least 10 years' duration and in 25 age- and sex-matched healthy control subjects. A significant correlation difference analysis was performed to determine which ROI pairs had reduced correlation coefficients (reduced functional neuronal connectivity). The vascular pattern of the reduction was determined after allocating the ROIs to their appropriate vascular territories.Results: Compared with the control subjects, hypertensive patients had reduced correlation coefficients in cortical territories of the internal carotid arteries but not of the vertebrobasilar arteries. The border zone supplied by the middle and anterior cerebral arteries was most affected.Conclusions: The border zone between the anterior and middle cerebral arteries is vulnerable to ischemia from carotid pathology, systemic hypotension, or both. We hypothesize that although these hypertensive patients were "well controlled" and had normal neuropsychological tests, they may have experienced ischemia severe enough to cause border zone reduction of functional neuronal connectivity as a result of carotid pathology, antihypertensive medications, hypotensive episodes with a right-shifted autoregulation curve, or other factors in isolation or combination.
SN  - 0039-2499
AD  - Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Md 20892.
U2  - PMID: 8128513.
DO  - 10.1161/01.STR.25.3.601
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104784581&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1994-37846-001
AN  - 1994-37846-001
AU  - Azari, Nina P.
AU  - Pettigrew, K. D.
AU  - Pietrini, P.
AU  - Horwitz, B.
AU  - Schapiro, M. B.
T1  - Detection of an Alzheimer disease pattern of cerebral metabolism in Down syndrome.
JF  - Dementia
JO  - Dementia
JA  - Dementia
Y1  - 1994/03//Mar-Apr, 1994
VL  - 5
IS  - 2
SP  - 69
EP  - 78
CY  - Switzerland
PB  - Karger
SN  - 1013-7424
N1  - Accession Number: 1994-37846-001. PMID: 8038869 Other Journal Title: Dementia and Geriatric Cognitive Disorders. Partial author list: First Author & Affiliation: Azari, Nina P.; NIH, National Institute on Aging, Lab of Neurosciences, Bethesda, MD, US. Release Date: 19941001. Correction Date: 20131014. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alzheimer's Disease; Down's Syndrome; Glucose Metabolism; Metabolic Rates; Neurochemistry. Minor Descriptor: Dementia; Frontal Lobe; Parietal Lobe. Classification: Mental Retardation (3256). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 10. Issue Publication Date: Mar-Apr, 1994. 
AB  - Tested whether discriminant functions, reflecting frontal-parietal regional cerebral metabolic rates for glucose (rCMRglc) interdependencies, that previously separated Alzheimer's disease (AD) from control Ss would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT–) dementia. The functions were applied to longitudinal rCMRglc data in: 15 young DS Ss (aged 22–38 yrs), 10 older DS DAT– Ss (aged 40–59 yrs), 4 DS DAT+ Ss (aged 45–67 yrs), and 15 young controls. All DS DAT+ and some of the later DS DAT– scans were classified as AD. The more reliable function, reflecting frontal-parietal rCMRglc/CMRglc interdependencies, detected an AD metabolic pattern in all DS DAT+ Ss and in later scans for all older DS DAT– Ss. Results validate the functions and suggest their utility for the early detection of AD. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - frontal parietal cerebral metabolic rates for glucose interdependencies
KW  - detection of Alzheimer's disease pattern
KW  - 22–67 yr olds with Down's syndrome with vs without dementia of Alzheimer's type
KW  - 1994
KW  - Alzheimer's Disease
KW  - Down's Syndrome
KW  - Glucose Metabolism
KW  - Metabolic Rates
KW  - Neurochemistry
KW  - Dementia
KW  - Frontal Lobe
KW  - Parietal Lobe
KW  - 1994
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1994-37846-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1995-85914-001
AN  - 1995-85914-001
AU  - Mautner, Susanne L.
AU  - Standl, A.
AU  - Pillau, H.
T1  - Wer überlebt im Pflegeheim? Situationsanalyse zur Mortalität im Pflegeheim und Untersuchung von Beurteilungskriterien mit prognostischer Valenz. = Who survives in a nursing home? Analysis of mortality in a nursing home and investigation of prognostic assessment criteria.
JF  - Zeitschrift für Gerontologie
JO  - Zeitschrift für Gerontologie
JA  - Z Gerontol
Y1  - 1994/03//Mar-Apr, 1994
VL  - 27
IS  - 2
SP  - 149
EP  - 156
CY  - Germany
PB  - Springer
SN  - 0044-281X
N1  - Accession Number: 1995-85914-001. PMID: 8053257 Translated Title: Who survives in a nursing home? Analysis of mortality in a nursing home and investigation of prognostic assessment criteria. Other Journal Title: Zeitschrift für Gerontologie und Geriatrie. Partial author list: First Author & Affiliation: Mautner, Susanne L.; National Institutes of Health, Bethesda, MD, US. Release Date: 19950401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: German. Major Descriptor: Death and Dying; Nursing Homes; Psychosocial Factors. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: Mar-Apr, 1994. 
AB  - Studied mortality in nursing home residents and factors predicting short-term or long-term survival after institutionalization. 317 deceased nursing home residents were catagorized into 6 groups, according to duration of survival after admission to the nursing home. Intergroup differences in age at admission, number of diagnoses, preadmission residence (private home vs hospital), communication capacity, orientation, mobility, and continence were analyzed. Results were used to develop the Nursing Home Survival Score which permits prognostic estimations of survival time in a nursing home. (English abstract) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - factors in long vs short term survival & mortality
KW  - elderly nursing home residents
KW  - Germany
KW  - 1994
KW  - Death and Dying
KW  - Nursing Homes
KW  - Psychosocial Factors
KW  - 1994
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-85914-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13539-007
AN  - 2008-13539-007
AU  - Logan, Ann
AU  - Berry, Martin
AU  - Gonzalez, Ana Maria
AU  - Frautschy, Sally A.
AU  - Sporn, Michael B.
AU  - Baird, Andrew
T1  - Effects of transforming growth factor β₁, on scar production in the injured central nervous system of the rat.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1994/03//
VL  - 6
IS  - 3
SP  - 355
EP  - 363
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Logan, Ann, Department of Clinical Chemistry, Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, United Kingdom, B15 2TH
N1  - Accession Number: 2008-13539-007. PMID: 8019673 Partial author list: First Author & Affiliation: Logan, Ann; Department of Molecular and Cellular Growth Biology, Whittier Institute for Diabetes and Endocrinology, La Jolla, CA, US. Other Publishers: Blackwell Publishing. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Logan, Ann. Major Descriptor: Central Nervous System; Injuries; Nerve Growth Factor; Neural Pathways; Neuroglia. Minor Descriptor: Neural Lesions; Rats; Growth Factor. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 1994. 
AB  - In the central nervous system (CNS), nerve regeneration after traumatic injury fails. The formation of a dense fibrous scar is thought to restrict in part the growth of axonal projections, providing one of the many reasons that complete lesions of neural pathways in the adult mammalian CNS are rarely followed by significant functional recovery. In order to determine which mechanisms mediate scar formation in the CNS and to investigate whether they can be modulated in vivo, we have attempted to define the potential role of trophic factors. Our previous studies have shown the focal elevation of transforming growth factor β₁ (TGFβ₁) expression in lesioned CNS tissue. In the studies described here, we demonstrate that TGFβ₁ participates in the scarring response in the rat brain. First, the elevated protein levels of TGFβ₁ are localized to specific populations of injury-responsive cells in the traumatized CNS. Furthermore, the injection of TGFβ₁ into the brains of injured rats causes a dramatic increase in the scarring response. Conversely, when neutralizing TGFβ₁ antibodies are administered, the deposition of fibrous scar tissue and the formation of a limiting glial membrane that borders the lesion is significantly attenuated, thus establishing a role for the endogenous growth factor in regulation of the non-glial component of the scar. In implicating TGFβ₁ in the scarring response in the CNS, the potential use for TGFβ₁ antagonists as inhibitors of scar formation in the injured mammalian CNS is self-evident. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - growth factor beta
KW  - scar production
KW  - injured central nervous system
KW  - rats
KW  - axonal projections
KW  - neural pathways
KW  - 1994
KW  - Central Nervous System
KW  - Injuries
KW  - Nerve Growth Factor
KW  - Neural Pathways
KW  - Neuroglia
KW  - Neural Lesions
KW  - Rats
KW  - Growth Factor
KW  - 1994
U1  - Sponsor: International Spinal Research Trust. Recipients: Logan, Ann
U1  - Sponsor: Wellcome Trust. Recipients: Logan, Ann; Berry, Martin
U1  - Sponsor: International Research Institute for Paraplegia. Recipients: Logan, Ann; Berry, Martin
U1  - Sponsor: Whittier/Erbamont Angiogenesis Program. Recipients: Baird, Andrew
U1  - Sponsor: National Institutes of Health, US. Grant: NS28121; DK18811; AG10685. Recipients: Baird, Andrew
U1  - Sponsor: National Institutes of Health, US. Grant: AG10685. Recipients: Frautschy, Sally A.
DO  - 10.1111/j.1460-9568.1994.tb00278.x
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UR  - ORCID: 0000-0003-0027-9905
UR  - 
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36261-007
AN  - 2015-36261-007
AU  - Brenner, Michael
AU  - Kisseberth, William C.
AU  - Su, Yuan
AU  - Besnard, Francois
AU  - Messing, Albee
T1  - GFAP promoter directs astrocyte-specific expression in transgenic mice.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/03//
VL  - 14
IS  - 3
SP  - 1030
EP  - 1037
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Brenner, Michael, SB/NINDS/NIH, Building 36, Room 4D-04, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36261-007. PMID: 8120611 Partial author list: First Author & Affiliation: Brenner, Michael; Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Messing, Albee. Major Descriptor: Proteins; Astrocytes; Neuroglia. Classification: Physiological Processes (2540). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 1994. Publication History: Accepted Date: Aug 9, 1993; Revised Date: Jul 27, 1993; First Submitted Date: Apr 14, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein expressed abundantly and almost exclusively in astrocytes of the CNS. We are studying transcriptional regulation of the GFAP gene to gain insight into astrocyte function and also to develop an astrocyte- specific expression system for manipulating brain physiology. In this work, we have produced transgenic mice carrying the bacterial lacZ reporter gene linked to a 2.2 kilobase 5′-flanking sequence derived from the human GFAP gene that previously was shown to direct astrocyte- specific transcription in cultured cells. We report that this promoter directs expression to astrocytes in the CNS. In addition, the upregulation of GFAP gene activity that follows injury to the brain was mimicked by the transgene. One of the transgenes was found to be X-linked and appeared to undergo the usual random inactivation that achieves gene dosage compensation in females. The brains of hemizygous females stained uniformly rather than displaying mosaic patches, indicating that astrocytes intermingle following their formation. The specific expression of the GFAP-lacZ transgene means that it is now possible to target expression of other heterologous genes to astrocytes in vivo, and to study the mechanisms for reactive gliosis at the DNA level. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - astrocytes
KW  - glial fritillary acidic protein
KW  - transgenic
KW  - gliosis
KW  - transcription
KW  - mouse
KW  - 1994
KW  - Proteins
KW  - Astrocytes
KW  - Neuroglia
KW  - 1994
U1  - Sponsor: National Multiple Sclerosis Society. Grant: RG 2487-A-1. Other Details: University of Wisconsin. Recipients: Messing, Albee
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36261-014
AN  - 2015-36261-014
AU  - Tan, Soon-Eng
AU  - Wenthold, Robert J.
AU  - Soderling, Thomas R.
T1  - Phosphorylation of AMPA-type glutamate receptors by calcium/calmodulin-dependent protein kinase II and protein kinase C in cultured hippocampal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/03//
VL  - 14
IS  - 3
SP  - 1123
EP  - 1129
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Soderling, Thomas R., Vollum Institute, Oregon Health Sciences University, L 474, 3181 SW Sam Jackson Park Road, Portland, OR, US, 97201
N1  - Accession Number: 2015-36261-014. PMID: 7509863 Partial author list: First Author & Affiliation: Tan, Soon-Eng; Vollum Institute, Oregon Health Sciences University, Portland, OR, US. Release Date: 20160606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Soderling, Thomas R. Major Descriptor: Calcium; Glutamate Receptors; Neurons; Protein Metabolism; AMPA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Mar, 1994. Publication History: Accepted Date: Aug 4, 1993; Revised Date: Aug 3, 1993; First Submitted Date: Apr 30, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Phosphorylation of glutamate receptors (GluRs) is emerging as an important regulatory mechanism. In this study 32P labeling of non-NMDA GluRs was investigated in cultured hippocampal neurons stimulated 2–15 min with agonists that selectively stimulate either Ca2+/calmodulin- dependent protein kinase II (CaM-kinase II), Ca2+/phospholipid- dependent protein kinase C (PKC), or cAMP-dependent protein kinase A (PKA). Treatment of hippocampal neurons with glutamate/glycine (Glu/Gly), ionomycin, or 12-O-tetradecanoylphorbol 13-acetate (TPA) increased ³²P labeling of immunoprecipitated α-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate (AMPA)-type GluRs by 145%, 180%, and 227%, respectively, of control values. This increased phosphorylation of GluRs was predominantly ³²P-Ser with little ³²P-Thr and no detectable ³²P-Tyr. Glu/Gly and ionomycin, but not TPA, also increased ³²P labeling of CaM-kinase II by 175% and 195%, respectively, of control values. Of these three agonists, only TPA stimulated phosphorylation of MARCKS (225% of control), a specific substrate of PKC. Forskolin treatment gave a three- to fourfold increase in the active catalytic subunit of PKA but did not result in the 32P labeling of AMPA-type GluRs, CaM-kinase II, or MARCKS. Phosphorylation of GluRs in response to Glu/Gly was blocked by a specific NMDA receptor/ion channel antagonist (DL-2-amino-5-phosphonovaleric acid) or by a cell- permeable inhibitor of CaM-kinase II (1-[N,O-bis(1,5- isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine, KN-62). These results are consistent with the hypothesis that Ca2+ influx through the NMDA-type ion channel can activate CaM-kinase II, which in turn can phosphorylate and regulate AMPA-type GluR ion channels (McGlade-McCulloh et al., 1993). Such a mechanism could contribute to the postsynaptic component of long-term potentiation and other forms of synaptic plasticity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - words: glutamate receptor
KW  - protein kinase
KW  - synaptic plasticity
KW  - hippocampus
KW  - calmodulin-kinase
KW  - 1994
KW  - Calcium
KW  - Glutamate Receptors
KW  - Neurons
KW  - Protein Metabolism
KW  - AMPA
KW  - 1994
U1  - Sponsor: National Institutes of Health, US. Grant: NS27037. Recipients: Soderling, Thomas R.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36261-022
AN  - 2015-36261-022
AU  - Polli, Joseph W.
AU  - Kincaid, Randall L.
T1  - Expression of a calmodulin-dependent phosphodiesterase isoform (PDE1B1) correlates with brain regions having extensive dopaminergic innervation.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/03//
VL  - 14
IS  - 3
SP  - 1251
EP  - 1261
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Polli, Joseph W., Department of Molecular Sciences, Glaxo Research Institute, V-295, 5 Moore Drive, Research Triangle Park, NC, US, 27709
N1  - Accession Number: 2015-36261-022. PMID: 8120623 Partial author list: First Author & Affiliation: Polli, Joseph W.; Section on Immunology, Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, US. Release Date: 20160606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Polli, Joseph W. Major Descriptor: Brain; Dopamine; Neurotransmitters; Phosphodiesterase. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Mar, 1994. Publication History: Accepted Date: Aug 10, 1993; Revised Date: Jul 13, 1993; First Submitted Date: Apr 9, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Cyclic nucleotide-dependent protein phosphorylation plays a central role in neuronal signal transduction. Neurotransmitter-elicited increases in cAMP/cGMP brought about by activation of adenylyl and guanylyl cyclases are downregulated by multiple phosphodiesterase (PDE) enzymes. In brain, the calmodulin (CaM)-dependent isozymes are the major degradative activities and represent a unique point of intersection between the cyclic nucleotide- and calcium (Ca2+)-mediated second messenger systems. Here we describe the distribution of the PDE1B1 (63 kDa) CaM-dependent PDE in mouse brain. An anti-peptide antiserum to this isoform immunoprecipitated ≈30–40% of cytosolic PDE activity, whereas antiserum to PDE1A2 (61 kDa isoform) removed 60–70%, demonstrating that these isoforms are the major CaM- dependent PDEs in brain. Quantification of PDE1B1 immunoreactivity on immunoblots indicated that striatum contains 3–17-fold higher levels of PDE1B1 than other brain regions, with lowest immunoreactivity in cerebellum. In situ hybridization demonstrated high levels of PDE1B1 mRNA in the caudate-putamen, nucleus accumbens, and olfactory tubercle. Moderate mRNA levels were observed in dentate gyrus, cerebral cortex, medial thalamic nuclei, and brainstem, whereas negligible mRNA was detectable in the globus pallidus, islands of Calleja, substantia nigra, and ventral tegmental area. Immunocytochemistry confirmed that the majority of PDE1B1 protein was localized to the caudate-putamen, nucleus accumbens, and olfactory tubercle. Within the caudate-putamen, PDE1B1 immunoreactivity was ubiquitous, while PDE1A2 immunostaining was restricted to a minor subset of striatal neurons. The expression of PDE1B1 protein and mRNA correlate strongly with areas of the brain that are richest in dopaminergic innervation; indeed, there are strikingly similar distributions for PDE1B1 and D₁ dopamine receptor mRNAs. Since D₁ receptor binding activates adenylyl cyclase, and striatal neurons lack CaM-sensitive forms of cyclase, the high amount of this PDE implies an important physiological role for Ca2+-regulated attenuation of cAMP-dependent signaling pathways following dopaminergic stimulation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CAMP
KW  - cyclase
KW  - striatum
KW  - dopamine
KW  - basal ganglia
KW  - DARPP-32
KW  - 1994
KW  - Brain
KW  - Dopamine
KW  - Neurotransmitters
KW  - Phosphodiesterase
KW  - 1994
U1  - Sponsor: National Institute of General Medical Sciences, US. Other Details: Pharmacology Research Associate Trainee (PRAT) fellowship. Recipients: Polli, Joseph W.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36261-028
AN  - 2015-36261-028
AU  - Irwin, Robert P.
AU  - Lin, Sui-Zhen
AU  - Long, Robert T.
AU  - Paul, Steven M.
T1  - N-methyl-D-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/03//
VL  - 14
IS  - 3
SP  - 1352
EP  - 1357
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Paul, Steven M., Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, US, 46285
N1  - Accession Number: 2015-36261-028. PMID: 8120630 Partial author list: First Author & Affiliation: Irwin, Robert P.; Section on Molecular Pharmacology, Clinical Neuroscience Branch, National Institute of Mental Health, NIH, Bethesda, MD, US. Release Date: 20160606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Calcium; Hippocampus; N-Methyl-D-Aspartate; Neurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Mar, 1994. Publication History: Accepted Date: Aug 19, 1993; Revised Date: Aug 9, 1993; First Submitted Date: Apr 19, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - The ability of NMDA to alter intracellular pH (pHi) was studied in fetal rat hippocampal neurons and glia using the pH-sensitive fluorescent indicator 2′,7′-bis-(2-carboxyethyl)-5-(and-6)- carboxyfluorescein (BCECF). Brief exposure (60 sec) of hippocampal neurons to NMDA (2.5–250 μM) results in a rapid, and in most cells reversible, reduction in pHi, with full recovery to baseline pHi values taking several minutes following removal of NMDA. In contrast, little or no change in pHi was observed in glial cells exposed to these same concentrations of NMDA. The NMDA-induced acidification of neurons was concentration and time dependent, with an EC50 of 39 μM and Emax (ΔpH) of -0.53. More prolonged exposure to NMDA (≥ 10 min) resulted in a more prolonged reduction in pHi values over the ensuing 20 min observation period. The intracellular acidification resulting from NMDA exposure of hippocampal neurons was blocked by the NMDA receptor antagonist 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP). Moreover, removal of extracellular Ca2+ eliminated both the selective NMDA-induced elevation in [Ca2+]i and the reduction in pHi, indicating that Ca2+ influx may be required for the decrease in pHi induced by NMDA receptor activation. Finally, the NMDA- induced reduction in pHi was not significantly attenuated when extracellular [H+] was decreased by increasing extracellular pH to 8.0. The latter suggests that an intracellular source of H+ is responsible for the NMDA-induced reduction in neuronal pHi. The reduction in neuronal pHi induced by NMDA receptor activation may mediate some of the physiological and (or) pathophysiological actions of glutamate. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - NMDA
KW  - receptor
KW  - intracellular pH
KW  - acidosis
KW  - calcium
KW  - neurotoxicity
KW  - 1994
KW  - Calcium
KW  - Hippocampus
KW  - N-Methyl-D-Aspartate
KW  - Neurons
KW  - 1994
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36261-062
AN  - 2015-36261-062
AU  - Allendoerfer, Karen L.
AU  - Cabelli, Robert J.
AU  - Escandón, Enrique
AU  - Kaplan, David R.
AU  - Nikolics, Karoly
AU  - Shatz, Carla J.
T1  - Regulation of neurotrophin receptors during the maturation of the mammalian visual system.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/03//
VL  - 14
IS  - 3
SP  - 1795
EP  - 1811
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
N1  - Accession Number: 2015-36261-062. PMID: 8126572 Partial author list: First Author & Affiliation: Allendoerfer, Karen L.; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, US. Release Date: 20160606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cabelli, Robert J. Major Descriptor: Visual Feedback; Brain Derived Neurotrophic Factor; Neurotrophic Factor. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Mar, 1994. Publication History: Accepted Date: Oct 4, 1993; Revised Date: Jul 26, 1993; First Submitted Date: Mar 17, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Cell division, cell death, and remodeling of connections are major features of the construction of the mammalian CNS. We have begun to address the role of neurotrophins in these events through characterization of the expression of their receptors in the developing ferret visual system. By use of chemical cross-linking of iodinated neurotrophins, proteins corresponding to trkB, trkC, and p75 were identified as receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) throughout development. BDNF was also cross- linked to a truncated form of trkB that lacks the tyrosine kinase domain (trkB. T1) in retinal target tissues and in cortex. At the earliest developmental age examined (E24), the ratio of full-length to truncated trkB is >> 1 in the retinal target tissues, LGN and superior colliculus. During the ensuing period of retinal ganglion cell death and segregation into eye-specific layers, the amount of truncated trkB increases markedly relative to full-length trkB. By P27, truncated trkB is the predominant receptor for BDNF in the retinal target tissues and this pattern is maintained into adulthood. Within all subdivisions of visual cortex including the ventricular zone (VZ), intermediate zone (IZ), and cortical plate (CP), similar profiles of bands are observed. The developmental increase in abundance of truncated trkB relative to full-length occurs earliest in the VZ, with a major increase between E30 and P3. In the IZ, this shift to a predominance of truncated trkB occurs between P15 and P30, while in the CP the shift is even further delayed, not occurring until after P30. Within each subdivision of cortex, the shift to a predominance of truncated trkB occurs at times that correlate with the onset of cell death and maturation of axonal connections. This study demonstrates that members of the trk family, previously identified in the CNS on the basis of mRNA transcripts, are present as receptors with specific binding affinities for BDNF and NT- 3. Moreover, the correspondence between the developmental shift from full-length to truncated trkB and the critical periods for cell fate determination, cell death, and axonal remodeling suggests an important role for neurotrophic factors in the development of the visual system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain-derived neorotrophic factor
KW  - NT-3
KW  - trkB
KW  - trkC
KW  - ~75
KW  - retina
KW  - cortex
KW  - cross-linking
KW  - 1994
KW  - Visual Feedback
KW  - Brain Derived Neurotrophic Factor
KW  - Neurotrophic Factor
KW  - 1994
U1  - Sponsor: National Institutes of Health, US. Grant: EY06327. Recipients: Cabelli, Robert J.
U1  - Sponsor: National Institutes of Health, US. Grant: NS07158. Recipients: Allendoerfer, Karen L.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Ito, Yasuhiko
AU  - Seto, Yushiyuki
AU  - Brannan, Cantilynn I.
AU  - Copeland, Neal G.
AU  - Jenkins, Nancy A.
AU  - Fukunaga, Rikiro
AU  - Nagata, Shigekazu
T1  - Structural analysis of the functional gene and pseudogene encoding the murine granulocyte colony-stimulating-factor receptor.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/03/15/
VL  - 220
IS  - 3
M3  - Article
SP  - 881
EP  - 891
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Granulocyte colony-stimulating factor is a cytokine which specifically regulates the production of neutrophilic granulocytes. The granulocyte colony-stimulating-factor receptor (GCSFR) is mainly expressed in neutrophils and their precursor cells. In this study, we isolated the chromosomal gene for murine GCSFR and determined its structure. Like the human GCSFR gene homolog, it consists of 17 exons. The exon-intron organization of the murine and human GCSFR-encoding genes are very similar, except that exon 14 and exon 15 in the murine gene are interrupted by a larger intron (greater than 10 kbp) than that found in the human gene (128 bp). This GCSFR-encoding functional gene (Csfgr) was localized to the distal region of murine chromosome 4 by interspecific backcross mapping. A comparison of the 5' flanking sequence of murine and human Csfgr revealed that a sequence of approximately 300 bp upstream from the cap site is highly conserved. Within this region an 18-nucleotide element conserved in the promoter of the genes for neutrophil-specific enzymes, was found approximately 140 bp upstream from the cap site, suggesting an involvement of this element in the specific expression of GCSFR in netrophilic granulocytes. In addition to the functional GCSFR-encoding gene we isolated a pseudogene for GCSFR, which is flanked by a 15-bp direct repeat at the 5' and 3' ends, and lacks all introns, exons 1-3 sequence of approximately 200 bp that is highly related to the DNA sequence approximately 1.2 kbp upstream of the cap site of the functional gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLONY-stimulating factors (Physiology)
KW  - GRANULOCYTES
KW  - NEUTROPHILS
KW  - PROMOTERS (Genetics)
KW  - ENZYMES
KW  - GENES
N1  - Accession Number: 13687513; Ito, Yasuhiko 1 Seto, Yushiyuki 1 Brannan, Cantilynn I. 2 Copeland, Neal G. 2 Jenkins, Nancy A. 2 Fukunaga, Rikiro 1 Nagata, Shigekazu 1; Affiliation:  1: Osaka Bioscience Institute, Japan  2: Mammalian Genetics Laboratory, National Cancer Institute-Fredericl Cancer Research and Development Center, Maryland, USA; Source Info: 3/15/94, Vol. 220 Issue 3, p881; Subject Term: COLONY-stimulating factors (Physiology); Subject Term: GRANULOCYTES; Subject Term: NEUTROPHILS; Subject Term: PROMOTERS (Genetics); Subject Term: ENZYMES; Subject Term: GENES; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104783652
T1  - The effects of order of questions on reported alcohol consumption.
AU  - Harford, T C
Y1  - 1994/04//
N1  - Accession Number: 104783652. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Questionnaires
KW  - Adolescence
KW  - Adult
KW  - Age Factors
KW  - Prospective Studies
KW  - Cross Sectional Studies
KW  - Human
KW  - Prevalence
KW  - United States
SP  - 421
EP  - 424
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 89
IS  - 4
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This research note draws upon the US National Longitudinal Survey (NLS) of Labor Market Experience among youths aged 17-24 to report the effects of variation in the ordering of alcohol questions upon the prevalence of heavier drinking. A secondary analysis of the NLS indicated a substantial decrease in the prevalence of heavier drinking between 1984 and 1985 which is attributed to the order of presentation of two differently styled questions regarding heavier drinking.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, Maryland 20857.
U2  - PMID: 8025495.
DO  - 10.1111/j.1360-0443.1994.tb00916.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rising, Russell
AU  - Harper, Ingeborg T.
AU  - Fontvielle, Anne Marie
AU  - Ferraro, Robert T.
AU  - Spraul, Maximilian
AU  - Ravussin, Eric
T1  - Determinants of total daily energy expenditure: variability in physical activity.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/04//
VL  - 59
IS  - 4
M3  - Article
SP  - 800
EP  - 804
SN  - 00029165
AB  - Excessive energy intake and/or reduced total daily energy expenditure (TEE) causes obesity. To determine the relationship between obesity and TEE in an obesity-prone population, we measured TEE, 24-h sedentary energy expenditure (SEDEE), and basal metabolic rate (BMR) in 30 Pima Indian men (83.6 ± 20.0 kg and 31 ± 9% fat) by the doubly labeled water method and a respiratory chamber. The energy expenditure for physical activity (EEACT TEE -- (BMR + 0.1 TEE), where 10% of TEE is an estimate of the thermic effect of food. Fat-free mass was the best single determinant (P < 0.01) of TEE, explaining 48% of its variance. TEE, SEDEE, BMR, and EEACF were 12 010 ± 2292, 9945 ± 1559, 7677 ± 1901, and 3297 ± 1732 kJ/d, respectively. Because EEACT is dependent on body weight, EEACT/kg body wt (41.7 ± 23.2 kJ · d-1 · kg-1) and TEE/(BMR + 0.1 TEE) (1.39 ± 0.22) were used as indexes of the level of physical activity. Both indexes correlated negatively with percent body fat (r = -0.56, P < 0.01 and r = -0.42, P < 0.03, respectively). These results suggest that obesity is associated with lower levels of physical activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Energy metabolism
KW  - Body composition
KW  - Physical activity
KW  - Obesity
KW  - Lean body mass
KW  - doubly labeled water
KW  - indirect calorimetry
N1  - Accession Number: 94424869; Rising, Russell 1; Harper, Ingeborg T. 1; Fontvielle, Anne Marie 1; Ferraro, Robert T. 1; Spraul, Maximilian 1; Ravussin, Eric 1; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Phoenix; Issue Info: Apr1994, Vol. 59 Issue 4, p800; Thesaurus Term: Energy metabolism; Thesaurus Term: Body composition; Subject Term: Physical activity; Subject Term: Obesity; Subject Term: Lean body mass; Author-Supplied Keyword: doubly labeled water; Author-Supplied Keyword: indirect calorimetry; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Harel, Yossi
AU  - Overpeck, Mary D.
AU  - Jones, Diane H.
AU  - Scheidt, Peter C.
AU  - Bijur, Polly E.
AU  - Trumble, Ann C.
AU  - Anderson, John
T1  - The Effects of Recall on Estimating Annual Nonfatal Injury Rates for Children and Adolescents.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/04//
VL  - 84
IS  - 4
M3  - Article
SP  - 599
EP  - 605
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives: This study used a recent national population survey on childhood and adolescent non-fatal injuries to investigate the effects of recall bias on estimating annual injury rates. Strategies to adjust for recall bias are recommended. Methods: The 1988 Child Health Supplement to the National Health Interview Survey collected 12-month recall information on injuries that occurred to a national sample of 17,110 children aged 0 through 17 years. Using information on timing of interviews and reported injuries, estimated annual injury rates were calculated for 12 accumulative recall periods (from 1 to 12 months). Results: The data show significantly declining rates, from 24.4 per 100 for a 1-month recall period to 14.7 per 100 for a 12-month recall period. The largest declines were found for the 0- through 4-year-old age group and for minor injuries. Rates of injuries that caused a school loss day, a bed day, surgery, or hospitalization showed higher stability throughout recall periods. Conclusions: Varying recall periods have profound effects on the patterns of childhood injury epidemiology that emerge from the data. Recall periods of between 1 and 3 months are recommended for use in similar survey settings. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILDREN -- Wounds & injuries
KW  - TEENAGERS -- Wounds & injuries
KW  - CHILDREN'S accidents
KW  - CHILDREN -- Hospital care
KW  - EPIDEMIOLOGY
N1  - Accession Number: 9406010235; Harel, Yossi 1 Overpeck, Mary D. 2 Jones, Diane H. 3 Scheidt, Peter C. 2 Bijur, Polly E. 4 Trumble, Ann C. 2 Anderson, John 3; Affiliation:  1: Medical Sociology Program, Bar Ilan University, Ramat Gan 52900, Israel  2: National Institute of Child Health and Human Development, Bethesda, Md.  3: Centers for Disease Control and Prevention, Atlanta, Ga.  4: Albert Einstein College of Medicine, Bronx, NY; Source Info: Apr94, Vol. 84 Issue 4, p599; Subject Term: CHILDREN -- Wounds & injuries; Subject Term: TEENAGERS -- Wounds & injuries; Subject Term: CHILDREN'S accidents; Subject Term: CHILDREN -- Hospital care; Subject Term: EPIDEMIOLOGY; Number of Pages: 7p; Illustrations: 9 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fikree, F. F.
AU  - Berendes, H. W.
T1  - Risk factors for term intrauterine growth retardation: a community-based study in Karachi.
T2  - Facteurs de risque de retard de croissance intra-utérine chez les enfants nés à terme: étude à base communautaire à Karachi.
JO  - Bulletin of the World Health Organization
JF  - Bulletin of the World Health Organization
Y1  - 1994/04//
VL  - 72
IS  - 4
M3  - Article
SP  - 581
EP  - 587
PB  - World Health Organization
SN  - 00429686
AB  - Reported are the results of a community-based prospective study in four urban squatter settlements in Karachi that was carried out to assess the incidence of and risk factors for intrauterine growth retardation. The incidence of term intrauterine growth retardation was 24.4% among 738 singleton births. The socioeconomic and biological risk factors that were found to be statistically significant in a bivariate analysis were included in a logistic regression model to assess their independent effects. The major risk factors were low level of maternal education, paternal unemployment, consanguinity, short birth-to-conception intervals, short maternal stature, and low maternal weight. The population risk estimates suggest the desirability of public health interventions to improve maternal weight and birth spacing and of improvements in socioeconomic conditions, especially maternal education. Public education programmes to discourage consanguineous marriages should also be considered. (English) [ABSTRACT FROM AUTHOR]
AB  - Une étude prospective à base communautaire a été réalisée dans quatre zones de squats à Karachi afin d'évaluer l'incidence et les facteurs de risque du retard de croissance intra-utérine chez les enfants nés à terme. Après recueil du consentement informé, 1000 femmes ont été recrutées dans l'étude. Pour déterminer la taille des échantillons pour les différents sites, en tenant compte des taux de grossesses et du nombre de femmes mariées en âge de procréer, on a procédé à une enquête rapide sur l'ensemble de ces femmes et un suivi mensuel des femmes non enceintes. Des renseignements détaillés sur les facteurs socio-économiques et demographiques, sur le regime alimentaire avant et pendant la grossesse, la consanguinité et divers paramétres médicaux et obstetricaux ont te obtenus Iors d'entretiens conduits par des médecins et infirmières spécialement formés. Chaque femme a subi un examen médical complet, avec prise de tension, mensurations et examen gynécologique. Dans les 24 à 96 heures suivant l'accouchement, on a note l'âge gestationnel, le poids à la naissance, le périmetre crânien et la taille du nouveau-né. L'incidence du retard de croissance intrautérine était de 24,4% Plusieurs paramètres socio-économiques, comme la qualité de la construction du logement, la situation professionnelle du père, le niveau d'études de la mère, la religion, le groupe ethnique, et l'approvisionnement en eau, étaient associés de façon significative au risque, de même que certaines données relatives à la mère, comme l'âge (<20 ans), la consanguinité et le décès d'un précedent enfant. On observait également une association significative pour des facteurs tels que l'intervalle entre l'accouchement et une nouvelle grossesse (≤12 mois ou ≥37 mois), la primiparité ou la grande multiparité (≥8). Les données anthropométriques (taille, poids, périmètre brachial, pli cutané) étoutes associées au risque. Une analyse de régression logistique a montré que certaines variables socio-économiques comme le faible niveau d'études de la mére et le chômage du père restaient significatives jusque dans le modèle final. Parmi les facteurs maternels, la consanguinité, la primiparité, la grande multiparité, la brièveté de l'intervalle entre l'accouchement et une nouvelle grossesse, la petite taille et le faible poids étaient significativement associés au retard de croissance intra-utérine. Une augmentation sensible du risque attribuable (≥20%) était associée au faible niveau d'études de la mère, à la consanguinité, à la primiparité, à la brièveté de l'intervalle entre l'accouchement et une nouvelle grossesse, et au faible poids de la mère. Ces résultats montrent la nécessité d'interventions de santé publique axées sur la planification familiale et sur l'amélioration de l'état nutritionnel des mères, surtout pendant la grossesse. II faut également reconnaître les effets nocifs de la consanguinité, et il est conseillé de prévoir une éducation du public à ce sujet.… (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Fetal growth retardation -- Risk factors
KW  - Childbirth
KW  - Unemployment
KW  - Consanguinity
KW  - Body weight
KW  - Karachi (Pakistan)
KW  - Pakistan
N1  - Accession Number: 24756190; Fikree, F. F. 1; Berendes, H. W. 2; Affiliations: 1: Senior Instructor, Department of Community Health Sciences, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan; 2: Director, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Issue Info: 1994, Vol. 72 Issue 4, p581; Subject Term: Fetal growth retardation -- Risk factors; Subject Term: Childbirth; Subject Term: Unemployment; Subject Term: Consanguinity; Subject Term: Body weight; Subject: Karachi (Pakistan); Subject: Pakistan; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Avanzini, M. A.
AU  - Björkander, J.
AU  - Söderström, R.
AU  - Söderström, T.
AU  - Schneerson, R.
AU  - Robbins, J. B.
AU  - Hansont, L. A.
T1  - Qualitative and quantitative analyses of the antibody response elicited by Haemophilus influenzae type b capsular polysaccharide-tetanus toxoid conjugates in adults with IgG subclass deficiencies and frequent infections.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1994/04//
VL  - 96
IS  - 1
M3  - Article
SP  - 54
EP  - 58
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Twenty-one IgG subclass-deficient adult patients with repeated infections of the respiratory tract, were immunized with Haemophilus influenzae type b capsular polysaccharide (HibCP) covalently bound to tetanus toxoid (TT). Specific immunoglobulin and IgG subclasses to HibCP and TT were quantified; the biological activities of HibCP antibodies were also investigated. Most patients showed an antibody response similar to that observed in healthy adults, and the bactericidal activity related to the post-immunization levels of HibCP antibodies. No relation was found between immunoglobulin isotype deficiency, the clinical symptoms and the IgG subclass responsiveness, and no relation was observed between HibCP and TT antibody responses. Our data indicate that some, but not all, patients with recurrent infections and IgG subclass deficiency have an abnormal serum antibody response to polysaccharide and protein epitopes of Hib-TT conjugate vaccine. Analysis of the antibody response after vaccination with HibCP-TT conjugate vaccine did not seem to predict the clinical course of such patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESPIRATORY infections
KW  - IMMUNOGLOBULINS
KW  - CLOSTRIDIUM diseases
KW  - BLOOD plasma
KW  - ANTIGENIC determinants
KW  - ANAEROBIC infections
KW  - antibody response
KW  - capsular polysaccharide
KW  - IgG subclasses
N1  - Accession Number: 16441285; Avanzini, M. A. 1 Björkander, J. 2 Söderström, R. 2 Söderström, T. 2 Schneerson, R. 3 Robbins, J. B. 3 Hansont, L. A. 3; Affiliation:  1: Department of Paediatrics, University of Pavia, Pavia, Italy,  2: Department of Clinical Immunology and Asthma and Allergy Research Centre, University of Gothenberg, Gothenberg, Sweden  3: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, MD, USA; Source Info: Apr1994, Vol. 96 Issue 1, p54; Subject Term: RESPIRATORY infections; Subject Term: IMMUNOGLOBULINS; Subject Term: CLOSTRIDIUM diseases; Subject Term: BLOOD plasma; Subject Term: ANTIGENIC determinants; Subject Term: ANAEROBIC infections; Author-Supplied Keyword: antibody response; Author-Supplied Keyword: capsular polysaccharide; Author-Supplied Keyword: IgG subclasses; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Helöe, Leif A.
AU  - Grytten, Jostein
AU  - Warren, Galen B.
AU  - Brown, L. Jackson
T1  - A comparative study of costs for dental services and dentists' incomes in the United States and Norway.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1994/04//
VL  - 22
IS  - 2
M3  - Article
SP  - 65
EP  - 70
SN  - 03015661
AB  - The United States and Norway have approximately the same per capita Gross Domestic Product (GDP) and average personal income, but their per capita health spending patterns are quite different. In 1982, the US spent 6.5% of its total health expenditures on dental services while Norway spent 5.4%. A higher percentage of Norwegian adults see a dentist annually as compared to US adults. In 1984, the mean net income of dentists in private practice was $66 940 in the US and $27 125 in Norway; this is respectively 5 and 1¾ times the average per capita income in those countries. The American publicly-employed dentist earned approximately two- thirds of what the American private practitioner made, while still earning approximately 50% more than his Norwegian counterpart. Sonic basic information concerning the ratios of dentists, specialists, and dental hygienists to the population is given. The relative proportion of women dentists in the two countries is contrasted. Finally, data on graduates from the dental schools, enrollment cuts, and estimated dentist to population ratios by the year 2000 are described to compare future manpower that will be available to the two countries. Several dissimilarities in the political and social systems are described and discussed. It is emphasized that caution should be used when interpreting and comparing data about countries with different dental delivery, political, and social systems. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOSPITAL dental service
KW  - DENTAL care
KW  - INCOME
KW  - DENTAL personnel
KW  - WOMEN in medicine
KW  - UNITED States
KW  - NORWAY
KW  - costs
KW  - dental services
KW  - dentist income
KW  - Norway
KW  - US
N1  - Accession Number: 12048113; Helöe, Leif A. 1 Grytten, Jostein 1 Warren, Galen B. 2 Brown, L. Jackson 2; Affiliation:  1: Institute of Community Dentistry, University of Oslo, Norway.  2: National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.; Source Info: Apr1994, Vol. 22 Issue 2, p65; Subject Term: HOSPITAL dental service; Subject Term: DENTAL care; Subject Term: INCOME; Subject Term: DENTAL personnel; Subject Term: WOMEN in medicine; Subject Term: UNITED States; Subject Term: NORWAY; Author-Supplied Keyword: costs; Author-Supplied Keyword: dental services; Author-Supplied Keyword: dentist income; Author-Supplied Keyword: Norway; Author-Supplied Keyword: US; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12048113
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schulkin, Jay
T1  - Melancholic Depression and the Hormones of Adversity: A Role for the Amygdala.
JO  - Current Directions in Psychological Science
JF  - Current Directions in Psychological Science
Y1  - 1994/04//
VL  - 3
IS  - 2
M3  - Article
SP  - 41
EP  - 44
PB  - Sage Publications Inc.
SN  - 09637214
AB  - Clinical depression affects 20% of the population over a lifetime. Women are particularly vulnerable to depression, with an incidence of nearly 3 to 1 compared with men. Although several types of depression can be distinguished, this article focuses on melancholic depression, also relevant to anxiety and fear. Melancholic or agitated depression is well characterized on clinical grounds. It consists of the activation of systems subserving arousal, vigilance, and attention, and the inhibition of systems controlling appetite, sleep, and sexual desires.
KW  - ADJUSTMENT disorders
KW  - DEPRESSION in women
KW  - MELANCHOLY
KW  - VIGILANCE (Psychology)
KW  - WOMEN -- Diseases
N1  - Accession Number: 10769930; Schulkin, Jay 1; Affiliation:  1: Chief, Behavioral Neuroscience Unit, Neuroendocrinology Branch, National Institute of Mental Health, building 10, Room 35231, Bethesda, MD 20892.; Source Info: Apr94, Vol. 3 Issue 2, p41; Subject Term: ADJUSTMENT disorders; Subject Term: DEPRESSION in women; Subject Term: MELANCHOLY; Subject Term: VIGILANCE (Psychology); Subject Term: WOMEN -- Diseases; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1467-8721.ep10769930
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ritter, M.
AU  - Huber, C.
AU  - Auböck, J.
AU  - Pohl-Markl, H.
AU  - Troppmair, J.
AU  - Herold, M.
AU  - Gächter, A.
AU  - Nussbaumer, W.
AU  - Böck, G.
AU  - Nachbaur, D.
AU  - Westhoff, U.
AU  - Eibl, B.
AU  - Schwaighofer, H.
AU  - Thaler, J.
AU  - Grosse-Wilde, H.
AU  - Niederwieser, D.
T1  - Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status.
JO  - Immunology
JF  - Immunology
Y1  - 1994/04//
VL  - 81
IS  - 4
M3  - Article
SP  - 569
EP  - 577
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Cytotoxic T-cell lines (TCL) were raised m vitro using stimulator cells with a defined major histocompatibility complex (MHC) mismatch and tested in a cytotoxic chromium-release assay against haemopoietic and non-haemopoietic target cells from the original stimulator. Monoclonal antibody (mAb)-blocking experiments and simultaneous determination of MHC class I, class II, lymphocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) density by quantitative radioimmunometric methods and flow cytometry on target cells demonstrated that lysis was restricted by MHC class I and dependent upon the constitutive MHC class I antigen expression. Measurements showed a high constitutive expression of class I MHC antigens on peripheral blood mononuclear cells (PBMC), but a low one on keratinocytes (K). Also. PBMC were more susceptible to lysis by TCL than K, interferon-γ (IFN-γ) treatment of K resulted in increased MHC class I antigen expression and enhanced lyric susceptibility to TCL. IFN-α and tumour necrosis factor-α (TNF-α) treatment, which did not modulate MHC class I antigen expression on K, did not influence the amount of K lysis either. None of the cytokines tested in this analysis, however, increased the expression of MHC class I, class II, ICAM-1 and LFA-1 on PBMC. Only IFN-γ pretreatment showed a minimal, statistically significant increase in MHC class I antigen expression. In spite of the minimal effect of IFN-γ and no effect of IFN-α on class I MHC expression, pretreatment of target cells with both cytokines considerably increased their lyric susceptibility. The mechanism of cytokine-induced enhanced lyric susceptibility to TCL was not explained by increased MHC class I, LFA-1 or ICAM-1 expression, since no correlation was found between surface expression of these molecules and lytic susceptibility to TCL. These data demonstrate that: (I) the constitutive density of MHC class I antigens determines the extent of TCL lysis; (2) IFN-γ, and not IFN-α or TNF-α, controls the amount of K target cell lysis by increasing their MHC class I antigen expression; and (3) IFN-γ and IFN-α control the amount of PBMC target cell lysis by a mechanism independent of MHC class I, 1CAM-I or LFA-1 expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - CELL-mediated cytotoxicity
KW  - MAJOR histocompatibility complex
KW  - ANTIGENS
KW  - IMMUNOGENETICS
KW  - IMMUNOLOGY
N1  - Accession Number: 13637138; Ritter, M. 1 Huber, C. 2 Auböck, J. 3 Pohl-Markl, H. 1 Troppmair, J. 4 Herold, M. 1 Gächter, A. 1 Nussbaumer, W. 5 Böck, G. 6 Nachbaur, D. 1 Westhoff, U. 7 Eibl, B. 1 Schwaighofer, H. 1 Thaler, J. 1 Grosse-Wilde, H. 7 Niederwieser, D. 1; Affiliation:  1: Division of Clinical Immunology and Department of Internal Medicine, University of Innsbruck, Austria  2: Department of Hematology, University of Mainz, Mainz  3: Department of Dermatology, University of Innsbruck, Austria  4: Viral Pathology Section, National Cancer Institute, Frederick, Maryland, U.S.A.  5: Institute for Blood Transfusion, University of Innsbruck, Austria  6: Department of General and Experimental Pathology, University of Innsbruck, Austria  7: Department of Immunology, University Hospital of Essen, Essen, Germany; Source Info: Apr94, Vol. 81 Issue 4, p569; Subject Term: T cells; Subject Term: CELL-mediated cytotoxicity; Subject Term: MAJOR histocompatibility complex; Subject Term: ANTIGENS; Subject Term: IMMUNOGENETICS; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Desanctis, J. B.
AU  - Varesio, L.
AU  - Radzioch, D.
T1  - Prostaglandins inhibit lipoprotein lipase gene expression in macrophages.
JO  - Immunology
JF  - Immunology
Y1  - 1994/04//
VL  - 81
IS  - 4
M3  - Article
SP  - 605
EP  - 610
PB  - Wiley-Blackwell
SN  - 00192805
AB  - In the present investigation of the effects of prostaglandin E2 (PGE2) on lipoprotein lipase (LPL) gene expression in macrophages, we observed that treatment of macrophages with PGE2 increased the levels of adenosine 3′,5′-cyclic monophosphate (cAMP), while the addition of exogenous 5-bromo-cAMP to macrophage cultures resulted in down-regulation of LPL expression. Using indomethacin (INDO), an inhibitor of cyclo-oxygenase and prostaglandins production, we determined that PGE2 acts as a feedback inhibitor of LPL expression. We found that inhibited secretion of LPL protein in lipopolysaccharide (LPS)-treated macrophages could be restored to control levels by the addition of INDO to the medium. In contrast, INDO did not reverse the inhibition of LPL mRNA induced by LPS. Overall, our results have demonstrated that PGE2 is a potent inhibitor of LPL gone expression and indicated that its action may play an important physiological role in the regulation of LPL gene expression during bacterial infections. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROSTAGLANDINS
KW  - LIPOPROTEIN lipase
KW  - MACROPHAGES
KW  - GENE expression
KW  - INDOMETHACIN
KW  - METABOLITES
KW  - ENZYMES
KW  - IMMUNOLOGY
N1  - Accession Number: 13637647; Desanctis, J. B. 1 Varesio, L. 2 Radzioch, D. 3; Affiliation:  1: Institute of Immunology, Central University of Venezuela, Caracas, Sabana Grande, Venezuela  2: Frederick Cancer Research Facility, National Cancer Institute, Frederick, Maryland, U.S.A.  3: McGill University, McGill Centre for the Study of Host Resistance, Montreal General Hospital, Quebec, Canada; Source Info: Apr94, Vol. 81 Issue 4, p605; Subject Term: PROSTAGLANDINS; Subject Term: LIPOPROTEIN lipase; Subject Term: MACROPHAGES; Subject Term: GENE expression; Subject Term: INDOMETHACIN; Subject Term: METABOLITES; Subject Term: ENZYMES; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Amagai, Masayuki
AU  - Kàrpàti, Sarolta
AU  - Klaus-Kovtun, Vera
AU  - Udey, Mark C.
AU  - Stanley, John R.
T1  - Extracellular Domain of Pemphigus Vulgaris Antigen (Desmoglein 3) Mediates Weak Homophilic Adhesion.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/04//
VL  - 102
IS  - 4
M3  - Article
SP  - 402
EP  - 408
SN  - 0022202X
AB  - Pemphigus vulgaris antigen is in the cadherin supergene family. We hypothesized that the extracellular domain of pemphigus vulgaris antigen might mediate homophilic cell adhesion because 1) the originally described cadherins (e.g., E-cadherin) mediate this type of adhesion, 2) pemphigus vulgaris antigen is localized in desmosomes that are cell adhesion junctions, and 3) autoantibodies in pemphigus vulgaris patients cause loss of cell adhesion. To test this hypothesis we used a system developed for E-cadherin that, when transfected into L cells (mouse fibroblasts), has been shown to cause aggregation. Because this aggregation requires the cytoplasmic domain of E-cadherin to bind to catenins, we made a chimeric cDNA construct that encodes the extracellular domain of pemphigus vulgaris antigen and the cytoplasmic domain of E-cadherin. Analysis by immunofluorescence and flow cytometry with pemphigus vulgaris sera indicated that the pemphigus vulgaris antigen extracellular domain of this chimeric molecule (PVEC) was expressed on the cell surface of transiently transfected cells and permanently transfected L-cell clones. Immunoprecipitation of the chimeric molecule from extracts of these clones showed that the E-cadherin cytoplasmic domain bound catenins. Surprisingly, these L- cell clones displayed only slight aggregation compared to an L-cell clone transfected with E-cadherin. This weak aggregation was, however, specific and homophilic, as determined by cell sorting of only PVEC transfectants into aggregates from mixtures of PVEC and neomycin resistance gene transfectants, one of which was labeled with a fluorescent dye. We conclude that the extracellular domain of pemphigus vulgaris antigen mediates weak homophilic adhesion and is not interchangeable in function with the extracellular domain of E-cadherin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEMPHIGUS
KW  - DESMOSOMES
KW  - EPITHELIAL cells
KW  - AUTOIMMUNE diseases
KW  - IMMUNOLOGIC diseases
KW  - ANTIBACTERIAL agents
KW  - ANTIBIOTICS
KW  - <em>autoimmune</em>
KW  - <em>cadherin</em>
KW  - <em>catenin</em>
KW  - <em>desmosome</em>
N1  - Accession Number: 12372164; Amagai, Masayuki 1 Kàrpàti, Sarolta 1 Klaus-Kovtun, Vera 1 Udey, Mark C. 1 Stanley, John R. 1; Affiliation:  1: Dermatology Branch, National Institutes of Health, Bethesda Maryland, U.S.A.; Source Info: Apr94, Vol. 102 Issue 4, p402; Subject Term: PEMPHIGUS; Subject Term: DESMOSOMES; Subject Term: EPITHELIAL cells; Subject Term: AUTOIMMUNE diseases; Subject Term: IMMUNOLOGIC diseases; Subject Term: ANTIBACTERIAL agents; Subject Term: ANTIBIOTICS; Author-Supplied Keyword: <em>autoimmune</em>; Author-Supplied Keyword: <em>cadherin</em>; Author-Supplied Keyword: <em>catenin</em>; Author-Supplied Keyword: <em>desmosome</em>; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12372164
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dlugosz, Andrzej A.
AU  - Yuspa, Stuart H.
T1  - Protein Kinase C Regulates Keratinocyte Transglutaminase (TGK) Gene Expression in Cultured Primary Mouse Epidermal Keratinocytes Induced to Terminally Differentiate by Calcium.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/04//
VL  - 102
IS  - 4
M3  - Article
SP  - 409
EP  - 414
SN  - 0022202X
AB  - During the final stage of epidermal differentiation, activation of keratinocyte transglutaminase results in covalent cross-linking of a variety of proteins to form highly protective cornified cell envelopes. We have studied the regulation of keratinocyte transglutaminase (TGK) gene expression in murine epidermal keratinocytes induced to terminally differentiate <em>in vitro</em> by increasing the level of extracellular Ca++ or treatment with the protein kinase C (PKC) activator 12- O-tetradecanoylphorbol-13-acetate (TPA). Raising extracellular Ca++ induces squamous differentiation of cultured keratinocytes and elicits a concentration-dependent increase in expression of TGK mRNA; keratinocytes grown for 24 h in 0.12 mM Ca++ medium express ∼12 times as much TGK mRNA as basal cells (grown in 0.05 mM Ca++ medium), whereas cultures exposed to 1.4 mM Ca++ express ∼17 times as much. TPA induces squamous differentiation and TGK mRNA even in basal keratinocyte cultures grown in 0.05 mM Ca++ medium, suggesting that expression of this differentiation marker is regulated by the PKC signaling pathway. Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca++- and TPA-treated keratinocytes. Induction of TGK mRNA by either TPA or Ca++ is blocked in the presence of cycloheximide, suggesting that a PKC-dependent protein factor is required for TGK gene expression in response to both stimuli. Furthermore, the accumulation of TGK mRNA in keratinocytes treated with TPA or CA++ is blocked in cells treated with the PKC inhibitor GF 109203X or bryostatin. These results suggest that the induction of TGK gene expression by CA++ is dependent on PKC, providing further support for the hypothesis that PKC plays a central role in regulating the late stages of epidermal differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL transcription
KW  - PHORBOL esters
KW  - COCARCINOGENS
KW  - KERATINOCYTES
KW  - PROTEIN kinases
KW  - PHOSPHOTRANSFERASES
KW  - <em>bryostatin</em>
KW  - <em>GF 109203X</em>
KW  - <em>phorbol ester</em>
KW  - <em>transcription</em>
N1  - Accession Number: 12372171; Dlugosz, Andrzej A. 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland U.S.A.; Source Info: Apr94, Vol. 102 Issue 4, p409; Subject Term: MEDICAL transcription; Subject Term: PHORBOL esters; Subject Term: COCARCINOGENS; Subject Term: KERATINOCYTES; Subject Term: PROTEIN kinases; Subject Term: PHOSPHOTRANSFERASES; Author-Supplied Keyword: <em>bryostatin</em>; Author-Supplied Keyword: <em>GF 109203X</em>; Author-Supplied Keyword: <em>phorbol ester</em>; Author-Supplied Keyword: <em>transcription</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12372171
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12372171&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Setoguchi, Yasuhiro
AU  - Jaffe, H. Ari
AU  - Danel, Claire
AU  - Crystal, Ronald G.
T1  - <em>Ex Vivo</em> and <em>In Vivo</em> Gene Transfer to The Skin Using Replication-Deficient Recombinant Adenovirus Vectors.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/04//
VL  - 102
IS  - 4
M3  - Article
SP  - 415
EP  - 421
SN  - 0022202X
AB  - The skin has the potential for a variety of gene therapy applications. In addition to local delivery, it is the largest organ of the body, and highly vascular, and thus is an ideal site for systemic delivery of gene products. To evaluate the potential for adenovirus-mediated skin gene transfer, the replication-deficient recombinant adenovirus vectors Ad.RSV βgal (coding for <em>Escherichia coli</em> β-galactosidase) and Adα1AT (coding for human α1-antitrypsin) were used in both <em>ex vivo</em> and <em>in vivo</em> approaches. Following <em>in vitro</em> infection with Ad.RSV βgal, murine keratinocytes expressed β-galactosidase. Parallel <em>in vitro</em> studies with Adα1AT documented <em>de novo</em> synthesis and secretion of human α1AT as shown by [35S]methionine labeling and immunoprecipitation. Quantification of human α1AT in the culture supernatants demonstrated 0.1 -0.3 μg human α1AT secreted/ml-24 h. Evaluation of the serum of mice receiving transplants (10 5 cells/ mouse) of Adα1AT-infected syngeneic keratinocytes demonstrated human α1AT for at least 14 d with maximum levels of 41 ng/ml. To demonstrate the feasibility of direct adenovirus-mediated <em>in vivo</em> transfer of genes to the skin, Ad.RSV βgal or Adα1AT were administered subcutaneously to mice. Histologic evaluation after 4 d demonstrated expression of β-galactosidase in various types of skin cells. Quantification of human α1AT in serum of animals infected subcutaneously with Adα1AT showed levels of 53 ng/ml at day 4, with human α1AT detectable for at least 14 d. These observations support the feasibility of <em>ex vivo</em> and <em>in vivo</em> gene transfer to the skin mediated by replication-deficient adenovirus vectors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE therapy
KW  - GENETIC engineering
KW  - KERATINOCYTES
KW  - IMMUNOLOGY
KW  - MICE
KW  - ESCHERICHIA coli
KW  - <em>α1-antitrypsin</em>
KW  - <em>β-galactosidase</em>
KW  - <em>gene therapy</em>
KW  - <em>keratinocyte</em>
N1  - Accession Number: 12372181; Setoguchi, Yasuhiro 1 Jaffe, H. Ari 1 Danel, Claire 1 Crystal, Ronald G. 2; Affiliation:  1: Pulmonary Branch, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda Maryland  2: Division of Pulmonary and Critical Care Medicine, Cornell University Medical College, New York, New York, U.S.A.; Source Info: Apr94, Vol. 102 Issue 4, p415; Subject Term: GENE therapy; Subject Term: GENETIC engineering; Subject Term: KERATINOCYTES; Subject Term: IMMUNOLOGY; Subject Term: MICE; Subject Term: ESCHERICHIA coli; Author-Supplied Keyword: <em>α1-antitrypsin</em>; Author-Supplied Keyword: <em>β-galactosidase</em>; Author-Supplied Keyword: <em>gene therapy</em>; Author-Supplied Keyword: <em>keratinocyte</em>; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12372181
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12372181&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Howard, Jan
AU  - Boyd, Gayle M.
AU  - Zucker, Robert A.
T1  - Overview of Issues.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1994/04//
VL  - 4
IS  - 2
M3  - Article
SP  - 175
EP  - 181
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - The article presents an overview of papers on alcohol use and abuse among adolescents included in the April 1994 issue of the journal "Journal of research on Adolescence." The issue of the journal is organized in terms of an implicit phases model. It begins with two analyses of risk and protective factors that influence adolescent drinking patterns over time without the intrusion of deliberate intervention. The papers focus on intervention research-studies that test or evaluate intervention strategies in terms of their impact or potential impact on alcohol use and abuse by adolescents.
KW  - ALCOHOLISM
KW  - TEENAGERS
KW  - DRINKING of alcoholic beverages
KW  - SUBSTANCE abuse
KW  - ALCOHOL
N1  - Accession Number: 11300252; Howard, Jan 1 Boyd, Gayle M. 1 Zucker, Robert A. 2; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism.  2: Michigan State University.; Source Info: 1994, Vol. 4 Issue 2, p175; Subject Term: ALCOHOLISM; Subject Term: TEENAGERS; Subject Term: DRINKING of alcoholic beverages; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOL; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1532-7795.ep11300252
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11300252&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107402079
T1  - Lipid levels in adults with cystic fibrosis.
AU  - Slesinski MJ
AU  - Gloninger MF
AU  - Costantino JP
AU  - Orenstein DM
Y1  - 1994/04//
N1  - Accession Number: 107402079. Language: English. Entry Date: 19950301. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Cystic Fibrosis -- In Adulthood
KW  - Lipids
KW  - Experimental Studies
KW  - Body Composition
KW  - Respiratory Function Tests
KW  - Hematologic Tests
KW  - Lipoproteins, HDL -- Analysis
KW  - Cholesterol -- Analysis
KW  - Triglycerides -- Analysis
KW  - T-Tests
KW  - Adult
KW  - Male
KW  - Female
KW  - Pearson's Correlation Coefficient
KW  - Data Analysis Software
KW  - Spearman's Rank Correlation Coefficient
KW  - Energy Intake
KW  - Human
SP  - 402
EP  - 408
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 94
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 8144807.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107402079&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - BIBEN, MAXEEN
AU  - BERNHARDS, DEBORAH
T1  - NAIVE RECOGNITION OF CHUCK CALLS IN SQUIRREL MONKEYS (SAIMIRI SCIUREUS MACRODON).
JO  - Language & Communication
JF  - Language & Communication
Y1  - 1994/04//
VL  - 14
IS  - 2
M3  - Article
SP  - 167
EP  - 181
SN  - 02715309
AB  - The article presents a study which examines whether a better response is obtained by the recorded chucks of natal group (NG) offspring than the unrelated strangers. The study uses the calls recorded from nine adult and subadult female NG offspring and the roles of strangers were performed by nine Saimiri (S.) sciureus macrodon. Results show that the chucks of daughters were more effective than strangers in eliciting a vocal response. It adds that the chucks of natal group offspring are recognized and preferred by animals over the chucks of strangers, despite being naïve to both.
KW  - Animal sounds
KW  - Sound production by animals
KW  - Saimiri sciureus
KW  - Natal Group (South Africa)
KW  - Strangers
KW  - Roles (Social aspects)
KW  - Animal offspring sex ratio
KW  - Macrodontogobius
KW  - Daughters
N1  - Accession Number: 83883044; BIBEN, MAXEEN 1; BERNHARDS, DEBORAH; Affiliations: 1: Building 112, Room 205, National Institutes of Health, Bethesda, MD 20892, U.S.A.; Issue Info: Apr1994, Vol. 14 Issue 2, p167; Thesaurus Term: Animal sounds; Thesaurus Term: Sound production by animals; Subject Term: Saimiri sciureus; Subject Term: Natal Group (South Africa); Subject Term: Strangers; Subject Term: Roles (Social aspects); Subject Term: Animal offspring sex ratio; Subject Term: Macrodontogobius; Subject Term: Daughters; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 2013-11806-001
AN  - 2013-11806-001
AU  - Stover, Ellen
AU  - Pequegnat, Willo
T1  - Editorial.
T3  - Serving People with Psychiatric Disability at Risk for HIV/AIDS
JF  - Psychosocial Rehabilitation Journal
JO  - Psychosocial Rehabilitation Journal
Y1  - 1994/04//
VL  - 17
IS  - 4
SP  - 1
EP  - 2
CY  - US
PB  - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN  - 0147-5622
N1  - Accession Number: 2013-11806-001. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Stover, Ellen; Office on AIDS, National Institute of Mental Health, NIH, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20130429. Correction Date: 20151102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: AIDS; AIDS Prevention; At Risk Populations; Mental Disorders; Mental Health Services. Minor Descriptor: Coping Behavior; HIV. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 2. Issue Publication Date: Apr, 1994. 
AB  - This editorial introduces a special issue on the issues related to serving people with psychiatric disability at risk for HIV/AIDS. Because of the urgency of the threat of HIV disease and its implications for service providers, articles in this special issue define the problem of HIV-risk behaviors among the seriously mentally ill and describe programs designed to prevent those behaviors. Other topics relevant to mental health service providers include HIV-prevention training for mental health service providers and coping with the threat of occupational exposure to HIV. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - at-risk populations
KW  - AIDS
KW  - HIV
KW  - psychiatric disability
KW  - mental health services
KW  - coping behavior
KW  - prevention
KW  - 1994
KW  - AIDS
KW  - AIDS Prevention
KW  - At Risk Populations
KW  - Mental Disorders
KW  - Mental Health Services
KW  - Coping Behavior
KW  - HIV
KW  - 1994
DO  - 10.1037/h0095562
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-11806-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2013-11807-001
AN  - 2013-11807-001
AU  - Stover, Ellen
AU  - Pequegnat, Willo
T1  - Introduction.
T3  - Serving People with Psychiatric Disability at Risk for HIV/AIDS
JF  - Psychosocial Rehabilitation Journal
JO  - Psychosocial Rehabilitation Journal
Y1  - 1994/04//
VL  - 17
IS  - 4
SP  - 3
EP  - 4
CY  - US
PB  - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN  - 0147-5622
N1  - Accession Number: 2013-11807-001. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Stover, Ellen; National Institute of Mental Health, National Institute of Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20130429. Correction Date: 20151102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; At Risk Populations; Health Education; Intervention; Mental Disorders. Minor Descriptor: AIDS; Behavior Change; Health Behavior; HIV; Public Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: Apr, 1994. 
AB  - Public education about risk is fundamental to AIDS prevention efforts, as it is for many other disease-prevention programs. But studies of all other areas of health-behavior change show that knowledge about risk, by itself, is usually insufficient to produce and sustain behavior change. This is particularly true of efforts to change sexual behavior or drug use—behaviors that are strongly motivated, pleasurable, complex, and poorly understood. Although the task is difficult, some NIMH-developed interventions have produced impressive reductions in AIDS-related high-risk behaviors. These interventions have relied on a combination of research-based understanding and systematic application of behavior-change techniques for specific populations and have been effective in promoting behavior change among such high-risk groups as homosexual men, runaway youths, and inner-city women. High-risk behavior can be modified, even among populations who are vulnerable to psychiatric illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - AIDS prevention
KW  - public education
KW  - health-behavior change
KW  - HIV
KW  - interventions
KW  - high-risk behaviors
KW  - high-risk groups
KW  - psychiatric illness
KW  - 1994
KW  - AIDS Prevention
KW  - At Risk Populations
KW  - Health Education
KW  - Intervention
KW  - Mental Disorders
KW  - AIDS
KW  - Behavior Change
KW  - Health Behavior
KW  - HIV
KW  - Public Health
KW  - 1994
DO  - 10.1037/h0095561
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-11807-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Sichieri, Rosely
AU  - Coitinho, Denise C.
AU  - Leão, Marília M.
AU  - Recine, Elisabetta
AU  - Everhart, James E.
T1  - High Temporal, Geographic, and Income Variation in Body Mass Index among Adults in Brazil.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/05//
VL  - 84
IS  - 5
M3  - Article
SP  - 793
EP  - 798
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Population-based data on body mass index for developing countries are scarce. Body mass index data from two Brazilian surveys were examined to determine regional and temporal variations in the prevalences of underweight, overweight, and obesity. Methods. Nationwide surveys in 1974/75 and 1989 collected anthropometric data in Brazil from 55 000 and 14 455 households, respectively. Trained interviewers used the same methods to measure weight and stature in both surveys, and survey designs were identical. Prevalences of underweight, overweight, and obesity were determined for persons 18-years-of age and older. Results. In the 1989 survey, body mass index varied greatly according to region of the country, urbanization, and income. In the wealthier South, the prevalence of overweight/ obesity was the highest and the prevalence of underweight was the lowest; in the poorer rural Northeast, these patterns were reversed. For both surveys, overweight/obesity was more common among women than among men and peaked at age 45 to 64 years in both sexes. Over the 15 years between surveys, the prevalence of both overweight and obesity increased strikingly. Conclusions. In contrast to findings in developed countries, obesity in Brazil was positively associated with income and was much more prevalent among women than among men. For Brazilian women, the overall prevalence of overweight was nearly as high as that among women in the United States. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POPULATION
KW  - BODY mass index
KW  - OBESITY
KW  - HEALTH surveys
KW  - DEVELOPING countries
KW  - BRAZIL
N1  - Accession Number: 9406223455; Sichieri, Rosely 1 Coitinho, Denise C. 2 Leão, Marília M. 2 Recine, Elisabetta 2 Everhart, James E. 3; Affiliation:  1: Centro de Ciências Biológicas e da Saûde Unìversìdade Estadual de Maringá, Paraná, Brazil  2: Centro Nacional de Epidemiologia e Informação-CENEI Sarah--Hospital de Medicina do Aparelho Locomotor, Brasília, Brazil  3: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md.; Source Info: May94, Vol. 84 Issue 5, p793; Subject Term: POPULATION; Subject Term: BODY mass index; Subject Term: OBESITY; Subject Term: HEALTH surveys; Subject Term: DEVELOPING countries; Subject Term: BRAZIL; Number of Pages: 6p; Illustrations: 3 Charts, 8 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thompson, Frances E.
AU  - Dennison, Barbara A.
T1  - Dietary Sources of Fats and Cholesterol in US Children Aged 2 through 5 Years.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/05//
VL  - 84
IS  - 5
M3  - Article
SP  - 799
EP  - 806
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study of lipid intakes among preschool children (1) analyzed the contributions of 38 food groups to fat, saturated fat, and cholesterol intakes; (2) estimated the effects of food substitutions on intakes; and (3) examined demographic differences in food group intake and food group sources of these lipids. Methods. The sample consisted of 547 children, aged 2 to 5 years, from the US Department of Agriculture's 1985 and 1986 Continuing Surveys of Food Intakes by Individuals, Dietary information for 4 nonconsecutive days throughout a year was used. All foods were classified into groups and the lipids contributed from each group were computed. Results. Over 80% of the children consumed more total fat, saturated fats, and cholesterol than is recommended. The major source of total fat and saturated fats was whole milk; the major sources of dietary cholesterol were eggs and whole milk. Children's food consumption patterns differed by region of the country and race/ethnicity, providing opportunities to refine nutrition education interventions and evaluations. Conclusions. By substituting lower-fat foods for the major sources of saturated fats, significant reductions in preschool children's intakes of saturated fats, fat, and dietary cholesterol could be achieved. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIPIDS
KW  - PRESCHOOL children
KW  - SATURATED fatty acids in human nutrition
KW  - NUTRITION
KW  - CHOLESTEROL
KW  - FOOD substitutes
KW  - DIETARY supplements
KW  - UNITED States
N1  - Accession Number: 9406223456; Thompson, Frances E. 1 Dennison, Barbara A. 2,3; Affiliation:  1: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.  2: Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY  3: Research Institute and Department of Pediatrics, Mary Imogene Bassett Hospital, Cooperstown, NY; Source Info: May94, Vol. 84 Issue 5, p799; Subject Term: LIPIDS; Subject Term: PRESCHOOL children; Subject Term: SATURATED fatty acids in human nutrition; Subject Term: NUTRITION; Subject Term: CHOLESTEROL; Subject Term: FOOD substitutes; Subject Term: DIETARY supplements; Subject Term: UNITED States; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Land, Kenneth C.
AU  - Guralnik, Jack M.
AU  - Blazer, Dan G.
T1  - Estimating Increment-Decrement Life Tables with Multiple Covariates from Panel Data: The Case of Active Life Expectancy.
JO  - Demography
JF  - Demography
Y1  - 1994/05//
VL  - 31
IS  - 2
M3  - Article
SP  - 297
EP  - 319
SN  - 00703370
AB  - This article describes a recent study of active life expectancy (ADL) for the elderly. It discusses an approach to an estimation based on an isomorphism between the structure of the stochastic model underlying a specification of the increment-decrement life table and Markov panel regression models for simple state spaces. The life table methods used to compute ALE have evolved from the prevalence-rate model to the double-decrement model to the multistate or increment-decrement model. These models usually are applied to data from relatively small panel studies of elderly people. Age-specific estimates of rates of disability from such panels typically exhibit erratic changes across the ages due to sampling and other stochastic fluctuations. An inability to estimate increment-decrement life tables from data on small panels in the presence of multiple covariate is a fundamental limitation of current multistate methodology. The article suggests and describe appropriate methods for such an estimation. Procedures described here are suggested to be more generally applicable to any substantive demographic, epidemiological, or social phenomenon for which suitable longitudinal panel data are available.
KW  - MORTALITY -- Tables
KW  - LIFE expectancy
KW  - OLDER people
KW  - LONGEVITY
KW  - MEDICAL anthropology
KW  - MARKOV processes
KW  - PANEL analysis
KW  - REGRESSION analysis
N1  - Accession Number: 9504071114; Land, Kenneth C. 1 Guralnik, Jack M. 2 Blazer, Dan G. 3; Affiliation:  1: Department of Sociology and Center for Demographic Studies and Center for Aging and Human Development Duke University Durham, NC 27708-0088.  2: Epidemiology, Demography, and B iometry Program, National Institute on Aging 7201 Wisconsin Avenue Bethesda, MD 20892.  3: Office of Medical Education, Box 3005 Duke University Medical Center Durham, NC 27710.; Source Info: May94, Vol. 31 Issue 2, p297; Subject Term: MORTALITY -- Tables; Subject Term: LIFE expectancy; Subject Term: OLDER people; Subject Term: LONGEVITY; Subject Term: MEDICAL anthropology; Subject Term: MARKOV processes; Subject Term: PANEL analysis; Subject Term: REGRESSION analysis; Number of Pages: 23p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wong, Paul
AU  - Taillefer, Daniet
AU  - Lakins, Johnathon
AU  - Pineault, Jean
AU  - Chader, Gerald
AU  - Thnniswood, Martin
T1  - Molecular characterization of human TRPM-2/clusterin, a gen associated with sperm maturation, apoptosis and neurodegeneration.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/05//5/1/94
VL  - 221
IS  - 3
M3  - Article
SP  - 917
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The TRPM-2/clusterin gene and its cognate protein has been characterized in a number of species. Although the functional role, or roles, of the TRPM-2/clusterin protein remains to be firmly established, the gene has been implicated in a variety of physiological processes, including sperm maturation, lipid transport, membrane remodelling and inhibition of the complement cascade. TRPM-2/clusterin is induced de novo during the regression of the prostate and other hormone-dependent tissues after hormone ablation, and is over-expressed in several human neurodegenerative diseases including Alzheimer's disease, epilepsy and retinitis pigmentosa. We describe the genomic structure of the human TRPM-2/clusterin gene which is organized into nine exons, ranging in size from 47 bp (exon I) to 412 bp (exon V), spanning a region of 16580 bp. Comparison with sequences registered in the databases shows that it has extensive similarity to the human protein designated as SP-40,40 or complement-lysis inhibitor (CLI), a protein that appears to block the membrane-attack complex of complement. However, the cDNA sequences reported for SP-40,40 and CLI diverge significantly in the 5' untranslated region of the mRNA (coded for by exon I), raising the possibility that the TRPM-2/clusterin gene is present in the human genome as a small multi-gene family or that there are several alternate exon I sequences in the TRPM-2 gene. Southern analysis and fluorescent in situ hybridization suggest that the clusterin gene is a single-copy gene, and that, if alternative exon I sequences are present in the genome, they lie outside of the A clones that have been characterized. Analysis of the promoter region of the human TRPM-2/clusterin gene shows many similarities to the rat TRPM-2/clusterin promoter including a putative control region containing several potential regulatory elements that may regulate the complex tissue-specific control of the gene which must be constitutively expressed in some tissues but is inducible in others. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CLUSTERIN
KW  - SPERMATOZOA
KW  - APOPTOSIS
KW  - GLYCOPROTEINS
N1  - Accession Number: 11225596; Wong, Paul 1,2 Taillefer, Daniet 1 Lakins, Johnathon 1 Pineault, Jean 1 Chader, Gerald 2 Thnniswood, Martin 1; Affiliation:  1: Department of Biochemistry, University of  Ottawa, Ottawa, Canada  2: Laboratory of Retinal Cell and Molecular Biology, National  Institutes of Health  (NE I),  Bethesda, USA.; Source Info: 5/1/94, Vol. 221 Issue 3, p917; Subject Term: CLUSTERIN; Subject Term: SPERMATOZOA; Subject Term: APOPTOSIS; Subject Term: GLYCOPROTEINS; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Just, Ingo
AU  - Wollenberg, Peter
AU  - Moss, Joel
AU  - Aktories, Klaus
T1  - Cysteine-specific ADP-ribosylation of actin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/05//5/1/94
VL  - 221
IS  - 3
M3  - Article
SP  - 1047
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Incubation of lysate from human polymorphonucleated neutrophils and human platelets with [[SUP32]P]NAD resulted in the labeling of a 42-kDa protein. Phosphodiesterase (Crotalus durissus) released 5'-AMP from the radiolabeled protein. The 42-kDa protein was identified as action by binding to DNAse-I, two-dimensional gel electrophoresis and partial proteolysis. The rate of ADP-ribosylation was greater with [[SUP32]P]ADP-ribose than with [[SUP32]P]NAD, indicating a non-enzymic modification.  ADP-ribose also modified actin in the actin-DNAse-I complex, but denatured actin was not modified by ADP-ribose. Only cytoplasmic β/γy-actin isoforms were non-enzymically ADP-ribosylated but not muscle α-actin. The acceptor amino acid was identified as a cysteine residue whereas the bacterial ADP-ribosyltransferase C. perfringens iota toxin catalyzes incorporation of ADP-ribose to Arg 177 of actin. Alkylation of cysteine residues of actin with N-ethylmaleimide prevented subsequent non-enzymic ADP-ribosylation but not the toxin catalyzed modification. Non-enzymically ADP-ribosylated actin was further modified by C. perfringens iota toxin. The F-actin stabilizing mycotoxin phalloidin blocked the non-enzymic ADP-ribosylation and, conversely, ADP-ribosylation inhibited the phalloidin-induced polymerization of ADP-ribosylated actin. The data indicate that cytoplasmic actin is non-enzymically ADP-ribosylated by ADP-ribose at a cysteine residue to inhibit actin polymerization. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ACTIN
KW  - CYSTEINE proteinases
KW  - NEUTROPHILS
KW  - PHOSPHODIESTERASES
N1  - Accession Number: 11226226; Just, Ingo 1 Wollenberg, Peter 1 Moss, Joel 2 Aktories, Klaus 1; Affiliation:  1: Institut für  Pharmakologie und Toxikologie der Universität des  Saarlandes,  Homburg-Saar, Germany.  2: Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health,  Bethesda, USA; Source Info: 5/1/94, Vol. 221 Issue 3, p1047; Subject Term: ACTIN; Subject Term: CYSTEINE proteinases; Subject Term: NEUTROPHILS; Subject Term: PHOSPHODIESTERASES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mukai, Takayo
AU  - Crago, Marjorie
AU  - Shisslak, Catherine M.
T1  - Eating Attitudes and Weight Preoccupation Among Female High School Students in Japan.
JO  - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF  - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1  - 1994/05//
VL  - 35
IS  - 4
M3  - Article
SP  - 677
EP  - 688
SN  - 00219630
AB  - Eating disorder tendencies in 197 eleventh grade Japanese girls were examined to ascertain whether or not the reported correlates of eating disorder tendencies in North America would be replicated in Japan. The 26-item Eating Attitudes Test was administered along with a set of supplementary questions. As hypothesized, higher levels of eating disturbances were found in the students who: (1) perceived themselves as being overweight, (2) had been encouraged to diet, (3) reported engaging in frequent conversations with their mother about food and dieting. Implications for future cross-cultural research are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Child Psychology & Psychiatry & Allied Disciplines is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EATING disorders
KW  - TEENAGERS
KW  - JAPANESE
KW  - WEIGHT gain
KW  - Adolescents
KW  - eating behavior
KW  - Japanese
KW  - weight.
N1  - Accession Number: 11540260; Mukai, Takayo 1 Crago, Marjorie 2 Shisslak, Catherine M. 2; Affiliation:  1: National Institute of Mental Health, Japan  2: Arizona Health Sciences Center, U.S.A.; Source Info: May1994, Vol. 35 Issue 4, p677; Subject Term: EATING disorders; Subject Term: TEENAGERS; Subject Term: JAPANESE; Subject Term: WEIGHT gain; Author-Supplied Keyword: Adolescents; Author-Supplied Keyword: eating behavior; Author-Supplied Keyword: Japanese; Author-Supplied Keyword: weight.; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1469-7610.ep11540260
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104784267
T1  - Pain measurement in cancer patients: a comparison of six methods.
AU  - De Conno, F
AU  - Caraceni, A
AU  - Gamba, A
AU  - Mariani, L
AU  - Abbattista, A
AU  - Brunelli, C
AU  - La Mura, A
AU  - Ventafridda, V
Y1  - 1994/05//1994 May
N1  - Accession Number: 104784267. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Verbal Rating Scale (VRS). NLM UID: 7508686. 
KW  - Neoplasms -- Complications
KW  - Pain Measurement -- Methods
KW  - Adult
KW  - Aged
KW  - Female
KW  - Human
KW  - Logistic Regression
KW  - Male
KW  - Middle Age
KW  - Questionnaires
KW  - Reproducibility of Results
KW  - Scales
SP  - 161
EP  - 166
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 57
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy.
U2  - PMID: 8090512.
DO  - 10.1016/0304-3959(94)90219-4
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
T1  - The Reliability and Validity of the 9-Minute Run in Third-Grade Children.
AU  - Turley, Kenneth R.
AU  - Wilmore, Jack H.
AU  - Simons-Morton, Bruce
AU  - Williston, Jean M.
AU  - Epping, Jackie Reeds
AU  - Dahlstrom, Ginny
JO  - Pediatric Exercise Science
JF  - Pediatric Exercise Science
Y1  - 1994/05//
VL  - 6
IS  - 2
SP  - 178
EP  - 187
SN  - 08998493
N1  - Accession Number: 20773978; Author: Turley, Kenneth R.: 1 Author: Wilmore, Jack H.: 1 Author: Simons-Morton, Bruce: 2 Author: Williston, Jean M.: 3 Author: Epping, Jackie Reeds: 4 Author: Dahlstrom, Ginny: 5 ; Author Affiliation: 1 Dept. of Kinesiology and Health Education, University of Texas at Austin, Belmont Hall 222, Austin, TX 78712: 2 National Institutes of Health, Dept. of Health and Human Services, Bldg. 6100, Rm. 7B05, Bethesda, MD 20892: 3 Dept. of Pediatrics-0927, Child & Family Health Studies, University of California at San Diego, 9500 Gilman Dr., LoJolla, CA 92093-0927: 4 School of Public Health & Tropical Medicine, Tulane University, 1501 Canal St., New Orleans, LA 70112: 5 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015; No. of Pages: 10; Language: English; Publication Type: Article; Update Code: 20060510
N2  - This study was designed to determine the validity and reliability of the 9-min distance run in assessing cardiorespiratory fitness in third-grade children. Fifty-one children (27 girls and 24 boys) participated in at least one maximal cycle ergometer test to determine peak oxygen consumption (VO2peak) and in two 9-min runs. Significant (p <<.01) test-retest intraclass correlations indicated that both the peak cycle ergometer test and the 9-min run were reliable measures in boys and girls and when the total sample was combined. Interclass correlations of r = .62 and r = .64 were attained between VO2peak (ml·kg-1min-1) and 9-min Run 1 and 9-min Run 2, respectively. When data were separated by gender, 9-min Run 1 and 9-min Run 2 correlated to VO2peak (r = .56 and r = .48 for the girls and r = .65 and r = .71 for the boys, respectively). These results suggest that the 9-min distance run is a reasonably valid and highly reliable field test for estimating cardiorespiratory fitness in third-grade children. ABSTRACT FROM AUTHOR
KW  - *PHYSICAL fitness testing
KW  - *PHYSICAL fitness for children
KW  - *RUNNING for children
KW  - *EXERCISE for children
KW  - *EXERCISE tests
KW  - *CARDIOPULMONARY system
KW  - *OXYGEN inhalation
KW  - *CHILDREN -- Health
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 107203127
T1  - Infant sleep position and risk of sudden infant death syndrome: report of meeting held January 13 and 14, 1994, National Institutes of Health, Bethesda, MD...including commentary by the American Academy of Pediatrics and Selected Agencies of the Federal Government
AU  - Willinger M
AU  - Hoffman HJ
AU  - Hartford RB
Y1  - 1994/05//
N1  - Accession Number: 107203127. Language: English. Entry Date: 19990801. Revision Date: 20170130. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422. 
KW  - Sudden Infant Death -- Epidemiology
KW  - Prone Position
KW  - Sudden Infant Death -- Prevention and Control
KW  - Sudden Infant Death -- Etiology
KW  - Infant Mortality -- Trends
KW  - Risk Factors
KW  - Sleep
SP  - 814
EP  - 819
JO  - Pediatrics
JF  - Pediatrics
JA  - PEDIATRICS
VL  - 93
IS  - 5
CY  - Chicago, Illinois
PB  - American Academy of Pediatrics
SN  - 0031-4005
AD  - Pregnancy and Perinatology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institute of Health
U2  - PMID: 8165085.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-06484-018
AN  - 2006-06484-018
AU  - West, Stephen G.
T1  - The Current Status of the Consistency Controversy in Personality.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1994/05//
VL  - 39
IS  - 5
SP  - 486
EP  - 487
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06484-018. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: West, Stephen G.; National Institute of Mental Health, Preventive Intervention Research Center, Arizona State University, Tempe, AZ, US. Release Date: 20061226. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Personality Traits; Social Psychology. Minor Descriptor: Genetics; Sociobiology. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Krahé, Barbara. Personality and Social Psychology: Towards a Synthesis=Newbury Park, CA: Sage, 1992. 278 pp. $59.95 hardcover, $19.95 paperback; 1992. References Available: Y. Page Count: 2. Issue Publication Date: May, 1994. 
AB  - Reviews the book, Personality and Social Psychology: Towards a Synthesis by Barbara Krahé (1992). This book represents the highest level of scholarship. The editors successfully integrates newer lines of work such as sociobiology, genetic approaches, and the act frequency approach to traits with older, mainstream consistency research. The sometimes divergent perspectives of European and North American psychologists are nicely brought together. The major positions relevant to each topic are carefully outlined, and the evidence supporting each position is reviewed prior to reaching a generally well-considered conclusion. Should the reader disagree with the conclusion, opposing arguments are always well laid out and carefully referenced so that the original sources can be pursued in more depth. Indeed, there are more than 600 references cited in this remarkable, yet slim volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - personality traits
KW  - social psychology
KW  - sociobiology
KW  - genetics
KW  - 1994
KW  - Personality Traits
KW  - Social Psychology
KW  - Genetics
KW  - Sociobiology
KW  - 1994
U2  - Krahé, Barbara. (1992); Personality and Social Psychology: Towards a Synthesis; Newbury Park, CA: Sage, 1992. 278 pp. $59.95 hardcover, $19.95 paperback; 0-8039-8724-2 (Hardcover); 0-8039-8725-0 (Paperback).
DO  - 10.1037/034317
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06484-035
AN  - 2006-06484-035
AU  - Newlin, David B.
T1  - In the Belly of the Beast: Toward a Motivational View of Addiction.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1994/05//
VL  - 39
IS  - 5
SP  - 511
EP  - 512
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06484-035. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Newlin, David B.; Addiction Research Center, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, US. Release Date: 20061226. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alcoholism; Drug Abuse; Drug Addiction; Drug Dependency; Neurobiology. Minor Descriptor: Nucleus Accumbens; Prefrontal Cortex; Tegmentum. Classification: Substance Abuse & Addiction (3233); Neuropsychology & Neurology (2520). Population: Human (10). Reviewed Item: Kalivas, Peter W. (Ed); Samson, Herman H. (Ed). The Neurobiology of Drug and Alcohol Addiction=New York: New York Academy of Sciences, 1992. 545 pp.; 1992. References Available: Y. Page Count: 2. Issue Publication Date: May, 1994. 
AB  - Reviews the book, The Neurobiology of Drug and Alcohol Addiction by Peter W. Kalivas and Herman H. Samson (Eds.) (1992). This book stems from a conference held in Spokane, Washington in July, 1991. It is unusually focused in comparison with most conference proceedings. This book has the advantage of being current in terms of its content and style. The chapters report interesting and vital experiments using state-of-the-art techniques, the collection of authors is impressive in its authority. The chief value of this book may be that it presents a modern view of drug abuse and dependence that has evolved over the last decade. This view assumes that relatively primitive brain structures, such as the ventral tegmental area--nucleus accumbens--medial prefrontal cortex dopaminergic system explored in these chapters, have evolved in birds and mammals to subserve basic motivational functions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug abuse
KW  - drug dependence
KW  - brain structures
KW  - ventral tegmental area
KW  - nucleus accumbens
KW  - prefrontal cortex
KW  - alcohol addiction
KW  - 1994
KW  - Alcoholism
KW  - Drug Abuse
KW  - Drug Addiction
KW  - Drug Dependency
KW  - Neurobiology
KW  - Nucleus Accumbens
KW  - Prefrontal Cortex
KW  - Tegmentum
KW  - 1994
U2  - Kalivas, Peter W. (Ed); Samson, Herman H. (Ed). (1992); The Neurobiology of Drug and Alcohol Addiction; New York: New York Academy of Sciences, 1992. 545 pp.; 0-89766-711-5 (Hardcover); 0-89766-712-3 (Paperback).
DO  - 10.1037/034334
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-06484-084
AN  - 2006-06484-084
AU  - Muntaner, Carles
T1  - More on In Search of Human Nature.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1994/05//
VL  - 39
IS  - 5
SP  - 554
EP  - 554
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06484-084. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Muntaner, Carles; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061226. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Darwinism; Human Nature; Theory of Evolution. Classification: Genetics (2510). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: May, 1994. 
AB  - The present author responds to Thomas J. Bouchard Jr.'s comments (see record [rid]2006-06465-110[/rid]) on Garland E. Allen's review (see record [rid]2006-06472-001[/rid]) of the book, In Search of Human Nature: The Decline and Revival of Darwinism in American Social Thought by Carl N. Degler (see record [rid]1991-98314-000[/rid]). The present author contends that Bouchard's dismissal of Allen's criticism on grounds that he relies on 'newspaper stories' is misplaced. Thanks to newspaper stories (i. e., freedom of expression), we have been informed about the Cyril Burt case (see Kamin, 1974) and other questionable claims of personality research that neo-Darwinian biologist and Harvard professor S. J. Gould has exposed through his popular writings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - human nature
KW  - Darwinism
KW  - evolution
KW  - 1994
KW  - Darwinism
KW  - Human Nature
KW  - Theory of Evolution
KW  - 1994
DO  - 10.1037/034383
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Grover, Surinder
AU  - Hamel, Ernest
T1  - The magnesium-GTP interaction in microtubule assembly.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/05/15/
VL  - 222
IS  - 1
M3  - Article
SP  - 163
EP  - 172
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Microtubule-associated-protein-dependent assembly of tubulin with GDP in the exchangeable site (tubulin-GDP) can occur with minimal free Mg2+ (<3 μM). This reaction is totally inhibited by EDTA and by GTP concentrations over 2 mM and stimulated by MgCI2. Quantitative aspects of this stimulation are affected by both the Mg2+ and GTP concentrations, but no relationship exists between reaction rates and relative amounts of different magnesium and GTP species. GTP binding to tubulin-GDP, while maximally stimulated 2-3-fold by exogenous MgCl2, was inhibited less than 50% by EDTA, and the amount of GTP bound increased as its concentration rose to levels that inhibited polymerization. Studies on the binding of Mg2+ to tubulin-GDP in the presence and absence of GTP showed that the increase in the amount of tubulin-associated Mg2+was substoichiometric to the amount of GTP bound (maximum stoichiometry of additional Mg2+ to GTP bound, 0.7). Upon polymerization the increased Mg2+ content of tubulin was reduced, indicating its loss during GTP hydrolysis. Mg2+ thus plays a critical role in assembly distinct from its enhancement of GTP binding to the exchangeable site. If magnesium is present in trace amounts, this role must either be catalytic during polymerization or limited to nucleation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUANOSINE triphosphate
KW  - MICROTUBULES
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
KW  - PROTEIN-protein interactions
KW  - PURINE nucleotides
N1  - Accession Number: 13103355; Grover, Surinder 1 Hamel, Ernest 1; Affiliation:  1: Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Source Info: 5/15/94, Vol. 222 Issue 1, p163; Subject Term: GUANOSINE triphosphate; Subject Term: MICROTUBULES; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Subject Term: PROTEIN-protein interactions; Subject Term: PURINE nucleotides; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kolar, Anne F.
AU  - Brown, Barry S.
AU  - Haertzen, Charles A.
AU  - Michaelson, Barry S.
T1  - Children of Substance Abusers: The Life Experiences of Children of Opiate Addicts in Methadone Maintenance.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1994/06//
VL  - 20
IS  - 2
M3  - Article
SP  - 159
EP  - 171
SN  - 00952990
AB  - We interviewed 70 substance abusers in methadone maintenance treatment regarding the life experiences of their 188 children. Sixty-four percent of the mothers reported using psychoactive drugs during their pregnancies. Eighty percent of parents reported an arrest during the time the child was growing up, 34% reported receiving treatment for an emotional disorder, and 14% were hospitalized. Four percent of the parents reported that their children had been placed in adoptive care, 9% in foster care, and 1% had a child in a group home. Forty-one percent of the parents reported that at least one of their children repeated a grade in school, 19% were involved in truancy, and 30% had been suspended from school. Twenty percent of parents reported their children's involvement with the law, and 17% reported drug or alcohol use. Problems with the law correlated highly with 1) being held back a grade, 2) truancy, 3) suspension from school, 4) expulsion from' school, and 5) treatment for alcohol or drug abuse. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - METHADONE treatment programs -- Side effects
KW  - DRUG abuse -- Treatment
KW  - ALCOHOLISM
KW  - CHILD care
KW  - DRUGS of abuse -- Law & legislation
KW  - SUBSTANCE abuse in pregnancy
N1  - Accession Number: 9410253069; Kolar, Anne F. 1 Brown, Barry S. 1 Haertzen, Charles A. 1 Michaelson, Barry S. 1; Affiliation:  1: Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland.; Source Info: 1994, Vol. 20 Issue 2, p159; Subject Term: METHADONE treatment programs -- Side effects; Subject Term: DRUG abuse -- Treatment; Subject Term: ALCOHOLISM; Subject Term: CHILD care; Subject Term: DRUGS of abuse -- Law & legislation; Subject Term: SUBSTANCE abuse in pregnancy; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wagener, Diane K.
AU  - Schatzkin, Arthur
T1  - Temporal Trends in the Socioeconomic Gradient for Breast Cancer Mortality among US Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/06//
VL  - 84
IS  - 6
M3  - Article
SP  - 1003
EP  - 1003
PB  - American Public Health Association
SN  - 00900036
AB  - Temporal trends in breast cancer mortality among US women were examined for 1969 through 1989 by age, race, and county-level socioeconomic statues (SES). The mortality ratio for high-relative to low-SES counties declined significantly among women 25 to 44, 45 to 64, and more than 65 years of age, respectively, from 1.13 to 0.96, 1.32 to 1.19, and 1.48 to 1.26. The narrowing of mortality occurred among Whites and, to a lesser extent, Blacks. A relative increase in either breast cancer incidence among women in lower SES countries or improved survival among women in higher SES counties (reflecting greater use of screening and treatment) could account for this relative worsening of breast cancer mortality among lower SES women in lower SES counties. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BREAST cancer
KW  - CANCER in women
KW  - MORTALITY & race
KW  - RACE
KW  - SOCIAL status
KW  - UNITED States
N1  - Accession Number: 9407141275; Wagener, Diane K. 1 Schatzkin, Arthur 2; Affiliation:  1: Office of Analysis, Epidemiology, and Health Promotion, National Center for Health Statistics, Hyattsville Md  2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md; Source Info: Jun94, Vol. 84 Issue 6, p1003; Subject Term: BREAST cancer; Subject Term: CANCER in women; Subject Term: MORTALITY & race; Subject Term: RACE; Subject Term: SOCIAL status; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bloom, Joan R.
AU  - Kessler, Larry
T1  - Emotional Support Following Cancer: A Test of the Stigma and Social Activity Hypotheses.
JO  - Journal of Health & Social Behavior
JF  - Journal of Health & Social Behavior
Y1  - 1994/06//
VL  - 35
IS  - 2
M3  - Article
SP  - 118
EP  - 133
SN  - 00221465
AB  - Reports of changes in emotional support following surgery for breast cancer can be attributed to one of two factors: (1) the stigma associated with cancer, or (2) illness-imposed restrictions in one's activities. These explanations were assessed using data from a longitudinal study of women, following their surgical treatment for early breast cancer (N = 145), gallbladder disease (N = 90), benign breast disease (N = 87), or no surgery (N = 90). Multiple regression analysis was used to test the two models. Contrary to the cancer stigma hypothesis, women with breast cancer initially perceived themselves to have more emotional support, rather than less. Type of surgery did not explain the level of emotional support as post-surgery time increased. Instead, support for the social activity hypothesis was found. The results are interpreted as indicating that breast cancer no longer carries with it a stigma, at least not to the extent of reducing the level of women's emotional support. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BREAST cancer -- Surgery
KW  - CANCER patients
KW  - STIGMA (Social psychology)
KW  - WOMEN -- Diseases
KW  - MEDICAL care
KW  - SURGERY
N1  - Accession Number: 9408032343; Bloom, Joan R. 1 Kessler, Larry 2; Affiliation:  1: University of California, Berkeley  2: The National Cancer Institute; Source Info: Jun1994, Vol. 35 Issue 2, p118; Subject Term: BREAST cancer -- Surgery; Subject Term: CANCER patients; Subject Term: STIGMA (Social psychology); Subject Term: WOMEN -- Diseases; Subject Term: MEDICAL care; Subject Term: SURGERY; Number of Pages: 16p; Illustrations: 8 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Shulman, Lawrence E.
T1  - Preface.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/06//
VL  - 102
IS  - 6
M3  - Editorial
SP  - 2S
EP  - 2S
SN  - 0022202X
AB  - The article reports on the Scientific Workshop on the Epidemiology of Skin Diseases which was convened in Bethesda, Maryland from March 25-26, 1994. The workshop objectives were to review the current state of knowledge and identify gaps in that knowledge, identify areas in which epidemiologic studies would advance understanding, management, and prevention of skin diseases to encourage more research into these areas identify research opportunities and propose research strategies, and stimulate discussion and planning among epidemiologists and dermatologists.
KW  - EPIDEMIOLOGY
KW  - SKIN diseases
KW  - WORKSHOPS (Adult education)
KW  - CONFERENCES & conventions
KW  - BETHESDA (Md.)
KW  - MARYLAND
KW  - UNITED States
N1  - Accession Number: 12385294; Shulman, Lawrence E. 1; Affiliation:  1: National Institute of Arthritis and Musculoskeletal and Skin Diseases.; Source Info: Jun94, Vol. 102 Issue 6, p2S; Subject Term: EPIDEMIOLOGY; Subject Term: SKIN diseases; Subject Term: WORKSHOPS (Adult education); Subject Term: CONFERENCES & conventions; Subject Term: BETHESDA (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 1p; Document Type: Editorial
L3  - 10.1111/1523-1747.ep12385294
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Amos, Christopher I.
AU  - Bale, Sherri J.
T1  - Genetic Epidemiologic Studies in the Etiology of Skin Diseases.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/06//
VL  - 102
IS  - 6
M3  - Article
SP  - 46S
EP  - 48S
SN  - 0022202X
AB  - Genetic epidemiologic studies have provided critical insights into the etiology of both rare and common skin diseases. Designs for these studies are distinct from those generally employed in epidemiologic studies. Here, we review the types of data collected for various genetic epidemiologic designs, inherent strengths and weaknesses, and their similarities to more classic epidemiologic methods. Examples from the study of skin diseases are provided to highlight the successful application of these methods. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN diseases
KW  - GENETIC research
KW  - DISEASES -- Causes & theories of causation
KW  - DERMATOLOGY
KW  - EPIDEMIOLOGY
KW  - PUBLIC health
N1  - Accession Number: 12388573; Amos, Christopher I. 1,2 Bale, Sherri J. 1; Affiliation:  1: Genetic Studies Section, Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland.  2: Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas, U.S.A.; Source Info: Jun94, Vol. 102 Issue 6, p46S; Subject Term: SKIN diseases; Subject Term: GENETIC research; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: DERMATOLOGY; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12388573
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12388573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bale, Sherri J.
AU  - Doyle, Sharon Z.
T1  - The Genetics of Ichthyosis: A Primer for Epidemiologists.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/06//
VL  - 102
IS  - 6
M3  - Article
SP  - 49S
EP  - 50S
SN  - 0022202X
AB  - Ichthyosis is a general term used to describe a heterogeneous group of skin disorders that are characterized by excessively dry skin and the accumulation of scale. Some ichthyoses are acquired and can occur in a variety of conditions including cancer, endocrine disease, and severe nutritional deficiencies In this paper the ichthyoses of genetic etiology, i.e., those that have been either inherited from a parent (or parents) or have occurred spontaneously but are due to a genetic mutation are discussed.
KW  - ICHTHYOSIS
KW  - GENETIC research
KW  - DISEASES -- Causes & theories of causation
KW  - FAMILIAL endocrine adenomatosis
KW  - MUTATION (Biology)
KW  - EPIDEMIOLOGY
N1  - Accession Number: 12388591; Bale, Sherri J. 1 Doyle, Sharon Z. 1; Affiliation:  1: Genetic Studies Section, Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun94, Vol. 102 Issue 6, p49S; Subject Term: ICHTHYOSIS; Subject Term: GENETIC research; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: FAMILIAL endocrine adenomatosis; Subject Term: MUTATION (Biology); Subject Term: EPIDEMIOLOGY; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12388591
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12388591&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wilmer, James L.
AU  - Burleson, Florence G.
AU  - Kayama, Fujio
AU  - Kanno, Jun
AU  - Luster, Michael I.
T1  - Cytokine Induction in Human Epidermal Kerationocytes Exposed to Contact Irritants and Its Relation to Chemical-Induced Inflammation in Mouse Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/06//
VL  - 102
IS  - 6
M3  - Article
SP  - 915
EP  - 922
SN  - 0022202X
AB  - In response to exogenous stimuli such as phorbol-12-myristate 13-acetate, ultraviolet B radiation, and lipopolysaccharide, human keratinocytes produce soluble mediators that are important in primary contact irritancy including cytokines that are associated with proinflammatory properties (interleukin-1α [IL-1α], tumor necrosis factor α), chemotaxis (IL-8), and growth activation (granulocyte/macrophage colony stimulating factor, IL-6, transforming growth factor α). We examined qualitative and quantitative changes in selected intracellular and secreted cytokines in human keratinocyte cultures in response to non-sensitizing contact irritants (croton oil, sodium lauryl sulfate, methyl salicylate, ethyl phenylpropiolate), sensitizing irritants (oxazolone, dinitrofluorobenzene), and ulcerative agents (phenol, benzalkonium chloride, chromium trioxide). The chemicals were also applied to mouse skin to assess whether the chemical-specific pattern of inflammation correlated with the <em>in vitro</em> production of keratinocyte-derived cytokines. Although all agents elicited neutrophils to the site of chemical application, time dependent and chemical-specific patterns of inflammation could be detected. Sodium lauryl sulfate, phenol, and croton oil induced increases in IL-8 production at non-cytotoxic concentrations in semi-confluent human keratinocyte cultures. Phenol and croton oil stimulated tumor necrosis factor α production, whereas croton oil was the only agent found to induce granulocyte/macrophage colony-stimulating factor production. Croton oil, phenol, benzalkonium chloride, and dinitrofluorobenzene induced the intracellular production of IL-1α without a concomitant release into the medium. The release of cytokines occurred in parallel with a relative increase in cytokine-specific mRNA transcripts. Studies using neutralizing antibodies to tumor necrosis factor α and IL-1α demonstrated that IL-8 induction by croton oil and phenol occured directly rather than through autocrine circuits. These data suggest that a given pattern of cytokine production is chemical-specific and may predict the contribution of keratinocytes to skin inflammation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOKINES
KW  - SKIN -- Inflammation
KW  - CHEMOTAXIS
KW  - KERATINOCYTES
KW  - NECROSIS
KW  - RNA
N1  - Accession Number: 12383512; Wilmer, James L. 1 Burleson, Florence G. 1 Kayama, Fujio 2 Kanno, Jun 3 Luster, Michael I. 1; Affiliation:  1: Immunology and Neurobiology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S.A.  2: Department of Environmental Health, University of Occupational and Environmental Health Medicine, Kitakyushu.  3: Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.; Source Info: Jun94, Vol. 102 Issue 6, p915; Subject Term: CYTOKINES; Subject Term: SKIN -- Inflammation; Subject Term: CHEMOTAXIS; Subject Term: KERATINOCYTES; Subject Term: NECROSIS; Subject Term: RNA; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12383512
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107418279
T1  - Can injurious falls be prevented?
AU  - Myers AN
AU  - Van Natta M
AU  - Robinson EG
AU  - Baker SP
Y1  - 1994///1994 Summer
N1  - Accession Number: 107418279. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Peer Reviewed; USA. Grant Information: National Institute on Aging and in part by the Centers for Disease Control to the Johns Hopkins University Injury Prevention Center. NLM UID: 0415026. 
KW  - Accidental Falls -- Prevention and Control -- In Old Age
KW  - Risk Factors -- In Old Age
KW  - Funding Source
KW  - Nursing Home Patients
KW  - Case Mix
KW  - Incident Reports
KW  - Nomenclature
KW  - Sex Factors
KW  - Tranquilizing Agents
KW  - Osteoarthritis
KW  - Heart Failure
KW  - Diuretics
KW  - Antiinflammatory Agents, Non-Steroidal
KW  - Potassium
KW  - Aged
KW  - Inpatients
KW  - Human
SP  - 26
EP  - 32
JO  - Journal of Long-Term Care Administration
JF  - Journal of Long-Term Care Administration
JA  - J LONG TERM CARE ADM
VL  - 22
IS  - 2
CY  - Alexandria, Virginia
PB  - American College of Health Care Administrators
SN  - 0093-4445
AD  - Laboratory of Behavioral Sciences, National Institute on Aging, NIH, Gerontology Research Center, Baltimore, MD
U2  - PMID: 10138000.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Podgor, Marvin J.
T1  - Nonparametric Measures of Association (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1994/06//
VL  - 89
IS  - 426
M3  - Book Review
SP  - 719
SN  - 01621459
AB  - Reviews the book "Nonparametric Measures of Association," by J.D. Gibbons.
KW  - NONPARAMETRIC statistics
KW  - NONFICTION
KW  - GIBBONS, J. D.
KW  - NONPARAMETRIC Measures of Association (Book)
N1  - Accession Number: 9501092105; Podgor, Marvin J. 1; Affiliations: 1: National Eye Institute, National Institutes of Health; Issue Info: Jun94, Vol. 89 Issue 426, p719; Thesaurus Term: NONPARAMETRIC statistics; Subject Term: NONFICTION; Reviews & Products: NONPARAMETRIC Measures of Association (Book); People: GIBBONS, J. D.; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 504
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107299148
T1  - Orthopedic management of malignant bone lesions.
AU  - Vargo MM
Y1  - 1994/06//1994 Jun
N1  - Accession Number: 107299148. Language: English. Entry Date: 19981201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8800867. 
KW  - Bone Neoplasms -- Rehabilitation
KW  - Neoplasm Metastasis
SP  - 363
EP  - 391
JO  - Physical Medicine & Rehabilitation
JF  - Physical Medicine & Rehabilitation
JA  - PHYS MED REHABIL STATE ART REV
VL  - 8
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - A fundamental challenge in the treatment of patients with bony metastatic disease is designing a rehabilitation program that combines safety and bone protection strategies with strengthening and mobility goals. In addition to addressing this challenge, this well-illustrated chapter covers the epidemiology, clinical features, diagnosis, the assessment of fracture risk, and the effects of radiation on malignant bone lesions.
SN  - 0888-7357
AD  - Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Marsman, Daniel S.
AU  - Barrett, J. Carl
T1  - Apoptosis and Chemical Carcinogenesis.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1994/06//
VL  - 14
IS  - 3
M3  - Article
SP  - 321
EP  - 326
SN  - 02724332
AB  - Long recognized as a normal component of organogenesis during development, apoptosis (programmed cell death) has recently been implicated in alterations of cell growth and differentiation. Tissue homeostasis is normally maintained by a balance between cell division and cell death, with apoptosis often functioning in complement to cell growth. Thus, antithetical parallels in chemical carcinogenesis can be drawn between apoptosis and the proliferative events more commonly addressed. While enhanced cell replication may contribute to an increased frequency of mutation, apoptosis within a tissue may counteract chemical carcinogenesis through loss of mutated cells. Many strong carcinogens act as tumor promoters, selectively expanding an initiated cell population advantageously over surrounding cells. Similarly, chemicals with a selective inhibition of apoptosis within an initiated population would offer a growth advantage. In contrast, chemicals causing selective apoptosis of initiated cells would be expected to have an anticarcinogenic effect. Selective apoptosis, in concert with cell-specific replication, may explain the unique promoting effects of different carcinogens such as the peroxisome-proliferating chemicals, phenobarbital, and 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). Cell turnover, both cell growth and cell death, is central to the process of chemically induced carcinogenesis in animals and understanding its impact is a critical determinant of the relevance of chemically induced effects to man. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Apoptosis
KW  - Cell death
KW  - Homeostasis
KW  - Peroxisomes
KW  - Cell proliferation
KW  - Apoptosis-liver/tumors/altered hepatic foci
KW  - Carcinogenesis
KW  - Cell growth and death, selective
KW  - cell growth-modeling
KW  - cell proliferation-homeostasis
KW  - Chemical effect mechanism
KW  - initiation/promotion
KW  - peroxisome proliferators
N1  - Accession Number: 8114562; Marsman, Daniel S. 1; Barrett, J. Carl 2; Affiliations: 1: Environmental Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, MD A0-01, Research Triangle Park, North Carolina 27709; 2: Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, P.O. Box 12233, MD C2-15, Research Triangle Park, North Carolina 27709; Issue Info: Jun94, Vol. 14 Issue 3, p321; Thesaurus Term: Apoptosis; Thesaurus Term: Cell death; Thesaurus Term: Homeostasis; Subject Term: Peroxisomes; Subject Term: Cell proliferation; Author-Supplied Keyword: Apoptosis-liver/tumors/altered hepatic foci; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Cell growth and death, selective; Author-Supplied Keyword: cell growth-modeling; Author-Supplied Keyword: cell proliferation-homeostasis; Author-Supplied Keyword: Chemical effect mechanism; Author-Supplied Keyword: initiation/promotion; Author-Supplied Keyword: peroxisome proliferators; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-24620-001
AN  - 2015-24620-001
AU  - Wolfe, Barry E.
T1  - Review of The self in emotional distress.
JF  - Journal of Psychotherapy Integration
JO  - Journal of Psychotherapy Integration
JA  - J Psychother Integr
Y1  - 1994/06//
VL  - 4
IS  - 2
SP  - 171
EP  - 174
CY  - US
PB  - Plenum Publishing Corp.
SN  - 1053-0479
SN  - 1573-3696
N1  - Accession Number: 2015-24620-001. Partial author list: First Author & Affiliation: Wolfe, Barry E.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Kluwer Academic/Plenum Publishers. Release Date: 20150615. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Behavior Therapy; Distress; Integrative Psychotherapy; Psychodynamics; Self-Concept. Minor Descriptor: Emotional Disturbances. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Segal, Z. V. (Ed); Blatt, S. J. (Ed). The self in emotional distress=New York: Guilford, 386 pp., $38.95; 1993. Page Count: 4. Issue Publication Date: Jun, 1994. Copyright Statement: Plenum Publishing Corporation. 1994. 
AB  - Reviews the book, The Self in Emotional Distress, edited by Z. V. Segal and S. J. Blatt (see record [rid]1993-97821-000[/rid]). One of the more remarkable developments within the field of psychology and psychotherapy is that the 'self,' a topic once thought consigned to the dustbin of history, has returned to a place of theoretical prominence. The self, in fact, is fast becoming a primary integrative focus for psychological models of psychopathology. Particularly within the cognitive-behavioral and psychodynamic perspectives, the self and self-representations are increasingly viewed as the 'final common pathway' for the acquisition and maintenance of a variety of emotional disorders. This volume is guided by two questions that the editors pose: (1) 'How do people with emotional disorders view themselves?' (2) 'Is there a relationship between a sense of self (self-perception and representation) and psychological difficulties?' The purpose of the book is to foster a dialogue between representatives of the cognitive-behavioral and psychodynamic perspectives where there has been much theorizing of late about the role of the self in specific emotional disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - self
KW  - emotional distress
KW  - emotional disorders
KW  - cognitive-behavioral perspective
KW  - psychodynamic perspective
KW  - integration
KW  - 1994
KW  - Cognitive Behavior Therapy
KW  - Distress
KW  - Integrative Psychotherapy
KW  - Psychodynamics
KW  - Self-Concept
KW  - Emotional Disturbances
KW  - 1994
U2  - Segal, Z. V. (Ed); Blatt, S. J. (Ed). (1993); The self in emotional distress; New York: Guilford, 386 pp., $38.95
DO  - 10.1037/h0101151
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-24620-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36295-038
AN  - 2015-36295-038
AU  - Wong, Linda A.
AU  - Mayer, Mark L.
AU  - Jane, David E.
AU  - Watkins, Jeffrey C.
T1  - Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/06//
VL  - 14
IS  - 6
SP  - 3881
EP  - 3897
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mayer, Mark L., National Institutes of Health, Building 49, Room 5A78, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36295-038. PMID: 7515954 Partial author list: First Author & Affiliation: Wong, Linda A.; Laboratory of Cellular and Molecular Neurophysiology, NICHD, National Institutes of Health, Bethesda, MD, US. Release Date: 20160620. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dorsal Roots; Ganglion Cells (Retina); Glutamic Acid; Hippocampus; AMPA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Jun, 1994. Publication History: Accepted Date: Dec 21, 1993; First Submitted Date: Sep 30, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Concentration jump responses to 5-substituted (S)-willardiines were recorded from dorsal root ganglion (DRG) and hippocampal neurons under voltage clamp. After block of desensitization by concanavalin-A, dose-response analysis for activation of kainate-preferring receptors in DRG neurons gave the potency sequence trifluoromethyl > iodo > bromo approximately chloro > nitro ≈ cyano > kainate > methyl > fluoro > (R,S)-AMPA >> willardiine; EC₅₀ values for the most and least potent willardiine derivatives, 5-trifluoromethyl (70 nM) and 5-fluoro (69 μM), differed 1000-fold. The potency sequence for equilibrium responses at AMPA-preferring receptors in hippocampal neurons was strikingly different from that obtained in DRG neurons: fluoro > cyano ≈ trifluoromethyl approximately nitro > chloro ≈ bromo > (R,S)-AMPA > iodo > willardiine > kainate > methyl. In hippocampal neurons EC₅₀ values for the most and least potent willardiine derivatives, 5-fluoro (1.5 microM) and 5-methyl (251 microM), differed only 170-fold. Consistent with equilibrium potency measurements, in DRG neurons the kinetics of deactivation for willardiines, recorded following a return to agonist-free solution, were rapid for 5-fluoro (τoff = 43 msec) but slow for 5-iodo (τoff = 4.2 sec), while the opposite sequence was observed for hippocampal neurons, slow for 5-fluoro (τoff = 2.1 sec) and rapid for 5-iodo (τoff = 188 msec). The kinetics of recovery from desensitization showed comparable agonist- and cell-dependent differences. Structure-activity analysis for agonist responses recorded from DRG and hippocampal neurons suggests that for both kainate-preferring and AMPA-preferring receptors the binding of willardiines involves interactions with polar groups such that potency is related to ionization of the uracil ring, and hence the electron-withdrawing ability of the 5-position substituent. However, kainate-preferring receptors differ from AMPA-preferring receptors in possessing a lipophilic pocket that further enhances agonist potency by hydrophobic bonding of the 5-substituent. In contrast, AMPA-preferring receptors lack such a lipophilic site, and for 5-position substituents of the same electron-withdrawing ability, potency decreases with increase in size. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate
KW  - kainate
KW  - AMPA
KW  - willardiine
KW  - desensitization
KW  - dose-response
KW  - dorsal root ganglion
KW  - hippocampus
KW  - 1994
KW  - Dorsal Roots
KW  - Ganglion Cells (Retina)
KW  - Glutamic Acid
KW  - Hippocampus
KW  - AMPA
KW  - 1994
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Obarzanek, Eva
AU  - Schreiber, George B.
AU  - Crawford, Patricia B.
AU  - Goldman, Susan R.
AU  - Barrier, Phyllis M.
AU  - Frederick, Margaret M.
AU  - Lakatos, Edward
T1  - Energy intake and physical activity in relation to indexes of body fat: the National Heart, Lung, and Blood Institute Growth and Health Study.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/07//
VL  - 60
IS  - 1
M3  - Article
SP  - 15
EP  - 22
SN  - 00029165
AB  - The relationship between energy intake, physical activity, and body fat was investigated in the baseline visit of 2379 black and white girls aged 9-10 y enrolled in the National Heart, Lung, and Blood Institute Growth and Health Study. Three-day food records, three-day physical activity diaries, physical-activity-patterns questionnaires, and an assessment of the number of hours of television and video watched were obtained. Multivariate-regression analyses showed that age, the number of hours of television and video watched, the percent of energy from saturated fatty acids, and the activity-patterns score best explained the variation in body mass index and sum of three skin-fold-thickness measurements for black girls. The best model for white girls included age, the number of hours of television and video watched, and the percent of energy from total fat. These results indicate that body fatness is related to energy intake and expenditure in both black and white girls. Longitudinal studies will help assess the value of these variables in predicting changes in body fat. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Energy metabolism
KW  - Food consumption
KW  - Saturated fatty acids in human nutrition
KW  - Body mass index
KW  - Physical activity
KW  - body mass index
KW  - energy intake
KW  - Fat intake
KW  - obesity
KW  - physical activity
KW  - skinfold thickness
KW  - television watching
KW  - National Heart Lung & Blood Institute
N1  - Accession Number: 94403878; Obarzanek, Eva 1,2,3,4,5,6; Schreiber, George B. 1,2,3,4,5,6; Crawford, Patricia B. 1,2,3,4,5,6; Goldman, Susan R. 1,2,3,4,5,6; Barrier, Phyllis M. 1,2,3,4,5,6; Frederick, Margaret M. 1,2,3,4,5,6; Lakatos, Edward 1,2,3,4,5,6; Affiliations: 1: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD; 2: Westat, Rockville, MD; 3: School of Public Health, University of California, Berkeley, CA; 4: Children's Hospital Medical Center, Cincinnati; 5: Group Health Association, Washington, DC; 6: Maryland Medical Research Institute, Baltimore; Issue Info: Jul1994, Vol. 60 Issue 1, p15; Thesaurus Term: Energy metabolism; Thesaurus Term: Food consumption; Subject Term: Saturated fatty acids in human nutrition; Subject Term: Body mass index; Subject Term: Physical activity; Author-Supplied Keyword: body mass index; Author-Supplied Keyword: energy intake; Author-Supplied Keyword: Fat intake; Author-Supplied Keyword: obesity; Author-Supplied Keyword: physical activity; Author-Supplied Keyword: skinfold thickness; Author-Supplied Keyword: television watching ; Company/Entity: National Heart Lung & Blood Institute; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hallfrisch, Judith
AU  - Singh, Vishwa N.
AU  - Muller, Denis C.
AU  - Baldwin, Howard
AU  - Bannon, Mary E.
AU  - Andres, Reubin
T1  - High plasma vitamin C associated with high plasma HDL-and HDL2 cholesterol.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/07//
VL  - 60
IS  - 1
M3  - Article
SP  - 100
EP  - 105
SN  - 00029165
AB  - High plasma vitamin C may lower risk of cardiovascular disease as indicated by direct association with plasma high-density-lipoprotein (HDL) cholesterol and HDL2 cholesterol. Plasma lipids and vitamin C were determined in 316 women and 511 men (aged 19-95 y). After adjustment for age, sex, obesity, and smoking, plasma vitamin C was directly associated with HDL- (P = 0.01) and HDL2 cholesterol (P = 0.0002). When men and women with diseases that might affect lipids were excluded, associations between plasma vitamin C and HDL- and HDL2 cholesterol persisted, though the relationships were strongest in older men. Comparisons of diets in a subset (n = 485) who completed 7-d diet records were made. Total fat, saturated fatty acids, energy from fat, and cholesterol intakes were not associated with plasma vitamin C. Mean intakes of vitamin C were well above recommended dietary allowances. These findings suggest that high plasma concentrations of vitamin C may lower atherogenic risk. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - Food consumption
KW  - Energy metabolism
KW  - Cardiovascular diseases -- Risk factors
KW  - Vitamin C in the body
KW  - Women
KW  - Blood cholesterol
KW  - atherogenesis
KW  - Cholesterol
KW  - lipoproteins
KW  - vitamin C
N1  - Accession Number: 94403871; Hallfrisch, Judith 1,2,3; Singh, Vishwa N. 1,2,3; Muller, Denis C. 1,2,3; Baldwin, Howard 1,2,3; Bannon, Mary E. 1,2,3; Andres, Reubin 1,2,3; Affiliations: 1: Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA, Beltsville, MD; 2: Hoffmann-LaRoche, Inc. Nutley, NJ; 3: Gerontology Research Center, National Institute on Aging, NIH, Baltimore; Issue Info: Jul1994, Vol. 60 Issue 1, p100; Thesaurus Term: HEALTH; Thesaurus Term: Food consumption; Thesaurus Term: Energy metabolism; Subject Term: Cardiovascular diseases -- Risk factors; Subject Term: Vitamin C in the body; Subject Term: Women; Subject Term: Blood cholesterol; Author-Supplied Keyword: atherogenesis; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: lipoproteins; Author-Supplied Keyword: vitamin C; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - NEWS
AU  - Goedert, James J.
AU  - Coté, Timothy R.
T1  - Editorial: Public Health Interventions to Reduce Pediatric AIDS.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/07//
VL  - 84
IS  - 7
M3  - Editorial
SP  - 1065
EP  - 1066
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses public health interventions to reduce pediatric AIDS. Over 5000 cases of pediatric acquired immunodeficiency syndrome or AIDS have been reported in the U.S. 88% of these infants inherited human immunodeficiency virus or HIV infection from their mothers. Approximately 7000 births now occur each year to HIV-infected women in the U.S., resulting in approximately 1500 HIV-infected infants. The most sudden change in obstetric practice in the U.S. is likely to be the use of zidovudine, which effectively lessened the mother-to-infant transmission rate from 25% to 8% when the drug was administered to HIV-infected women during pregnancy and labor, and to the offspring for 6 weeks.
KW  - PUBLIC health
KW  - AIDS (Disease) in children
KW  - AIDS (Disease) -- Transmission
KW  - HIV infections
KW  - AZT (Drug)
KW  - UNITED States
N1  - Accession Number: 9408031426; Goedert, James J. 1 Coté, Timothy R. 1; Affiliation:  1: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Md.; Source Info: Jul1994, Vol. 84 Issue 7, p1065; Subject Term: PUBLIC health; Subject Term: AIDS (Disease) in children; Subject Term: AIDS (Disease) -- Transmission; Subject Term: HIV infections; Subject Term: AZT (Drug); Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107416515
T1  - Update on colorectal cancer screening.
AU  - Johnson KA
AU  - Kramer BS
Y1  - 1994/07//1994 Jul
N1  - Accession Number: 107416515. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; pictorial; statistics; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100968228. 
KW  - Cancer Screening
KW  - Colorectal Neoplasms -- Diagnosis
KW  - Colorectal Neoplasms -- Prevention and Control
KW  - United States
KW  - Child
KW  - Middle Age
KW  - Aged, 80 and Over
SP  - 14
EP  - 23
JO  - Contemporary Oncology
JF  - Contemporary Oncology
JA  - CONTEMP ONCOL
VL  - 4
IS  - 7
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
SN  - 1061-0383
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Camera, Luigi
AU  - Kinuya, Seigo
AU  - Garmestani, Kayhan
AU  - Brechbiel, Martin
AU  - Wu, Chuanchu
AU  - Pai, Lee
AU  - McMurry, Thomas
AU  - Gansow, Otto
AU  - Pastan, Ira
AU  - Paik, Chang
AU  - Carrasquillo, Jorge
T1  - Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1 B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA).
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1994/07//
VL  - 21
IS  - 7
M3  - Article
SP  - 640
EP  - 646
SN  - 03406997
N1  - Accession Number: 71154461; Camera, Luigi 1 Kinuya, Seigo 1 Garmestani, Kayhan 2 Brechbiel, Martin 2 Wu, Chuanchu 2 Pai, Lee 3 McMurry, Thomas 2 Gansow, Otto 2 Pastan, Ira 3 Paik, Chang 1 Carrasquillo, Jorge 1; Affiliation:  1: Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike 20892 Bethesda USA  2: Chemistry Section, Radiation Oncology Branch, National Institutes of Health, 9000 Rockville Pike 20892 Bethesda USA  3: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike 20892 Bethesda USA; Source Info: Jul1994, Vol. 21 Issue 7, p640; Number of Pages: 7p; Document Type: Article
L3  - 10.1007/BF00285586
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107416999
T1  - Violent behavior by individuals with serious mental illness.
AU  - Torrey EF
Y1  - 1994/07//
N1  - Accession Number: 107416999. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9213225. 
KW  - Mental Disorders
KW  - Violence
KW  - Attitude to Mental Illness
KW  - Mentally Ill Offenders
KW  - Prisoners
KW  - Psychiatric Patients
KW  - Communications Media
KW  - Deinstitutionalization
KW  - Patient Compliance
KW  - Mental Health Services
KW  - Psychiatric Care
KW  - Involuntary Commitment
SP  - 5
EP  - 17
JO  - Innovations & Research
JF  - Innovations & Research
JA  - INNOV RES
VL  - 3
IS  - 3
CY  - Boston, Massachusetts
PB  - Boston University, Department of Rehabilitation Counseling
AB  - Objective: The perceived association between violent behavior and serious mental illness was explored to determine the validity of claims by mental health advocates that individuals with serious mental illness are no more dangerous than members of the general population. Methods: The author reviewed recent studies and media accounts of violent behavior by individuals with serious mental illness, with emphasis given to the most recent studies. Results and conclusions: Although the vast majority of individuals with serious mental illness are not more dangerous than members of the general population, recent findings suggest the existence of a subgroup that is more dangerous. A history of violent behavior, noncompliance with medications, and substance abuse are important predictors of violent behavior in this subgroup. The findings imply that the criteria for involuntary hospitalization, involuntary medication, outpatient commitment, the monitoring of medication compliance, and other mandated follow-up procedures may need to be revised. The existence of a subgroup of seriously mentally ill patients who exhibit violent behavior undermines efforts by mental health advocates to reduce the stigma of mental illness by denying an association with violence. Until the problem of violence by this subgroup is addressed, it will be difficult to substantially decrease the stigma associated with serious mental illness.
SN  - 1062-7553
AD  - National Institute of Mental Health Neuroscience Center, St Elizabeths Hospital, 2700 Martin Luther King Avenue, SE, Washington, DC 20032
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - RPRT
AU  - Moriwaki, Shin-Ichi
AU  - Tarone, Robert E.
AU  - Kraemer, Kenneth H.
T1  - A Potential Laboratory Test for Dysplastic Nevus Syndrome: Ultraviolet Hypermutability of a Shuttle Vector Plasmid.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/07//
VL  - 103
IS  - 1
M3  - Report
SP  - 7
EP  - 13
SN  - 0022202X
AB  - The diagnosis of the melanoma-prone disorder dysplastic nevus syndrome (DNS) is based currently on a combination of clinical and histopathologic examinations of patients. To develop a potential laboratory test for DNS, we utilized the observation that an ultraviolet light (UV)-treated mutagenesis plasmid shuttle vector has an abnormally increased frequency of mutations after transfection into lymphoblastoid cells from a patient with familial DNS. pSPI89 (containing the bacterial suppressor tRNA gene <em>supF</em> as a marker for mutations and a gene for ampicillin resistance for selection) was treated with UV and transfected into familial DNS, xeroderma pigmentosum complementation group A (XP-A), and normal lymphoblastoid cells by electroporation or diethylaminoethyl (DEAE) dextran. Untreated plasmid pZ189K (containing a gene for kanamycin resistance) was co-transfected as an internal standard to reduce the variability of plasmid survival measurements. After 2 d, plasmids were extracted, used to transform an indicator strain of <em>Escherichia coil</em>, and assayed on plates containing ampicillin or kanamycin, Counting light blue or white colonies (containing mutated <em>supF</em> In the plasmid) and blue colonies (with wild type <em>supF</em>) permitted measurement of the plasmid survival and mutation frequency. Transfection by electroporation or DEAE dextran resulted in abnormally reduced survival of UV-treated plasmid after passage through the XP-A but normal survival in the three DNS lines, Transfection of UV- treated plasmid by DEAE dextran yielded a greater hypermutability with the familial DNS lines than by electroporation. These results suggest that pSP189 UV hypermutability with normal UV survival using DEAE dextran transfection may form the basis of a potential laboratory assay for familial DNS. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOMA
KW  - DNA repair
KW  - BIOCHEMICAL genetics
KW  - GENE transfection
KW  - VIRAL genetics
KW  - NUCLEIC acids
KW  - LYMPHOBLASTOID cell lines
KW  - <em>DNA repair</em>
KW  - <em>lymphoblastoid cells</em>.
KW  - <em>melanoma</em>
KW  - <em>transfection</em>
N1  - Accession Number: 12388847; Moriwaki, Shin-Ichi 1 Tarone, Robert E. 2 Kraemer, Kenneth H. 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, Bethesda, Maryland, USA.  2: Biostatistics Branch, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jul94, Vol. 103 Issue 1, p7; Subject Term: MELANOMA; Subject Term: DNA repair; Subject Term: BIOCHEMICAL genetics; Subject Term: GENE transfection; Subject Term: VIRAL genetics; Subject Term: NUCLEIC acids; Subject Term: LYMPHOBLASTOID cell lines; Author-Supplied Keyword: <em>DNA repair</em>; Author-Supplied Keyword: <em>lymphoblastoid cells</em>.; Author-Supplied Keyword: <em>melanoma</em>; Author-Supplied Keyword: <em>transfection</em>; Number of Pages: 6p; Document Type: Report
L3  - 10.1111/1523-1747.ep12388847
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Duncan, Connie C.
AU  - Rumsey, Judith M.
AU  - Wilkniss, Sandra M.
AU  - Denckla, Martha B.
AU  - Hamburger, Susan D.
AU  - Odou-Potkin, Martha
T1  - Developmental dyslexia and attention dysfunction in adults: Brain potential indices of information processing.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1994/07//
VL  - 31
IS  - 4
M3  - Article
SP  - 386
EP  - 401
SN  - 00485772
AB  - Event-related brain potentials (ERPs) were recorded from a group of 13 men with severe developmental dyslexia and 15 matched normal controls. Auditory and visual stimuli, presented in separate reaction time tasks of graded difficulty, were used to elicit ERPs. No group differences in P300 were seen under relatively undemanding task conditions. However, as task demands increased, visual P300 was reduced in the dyslexic men as compared with the normal readers. An Abbreviated Conners Parent Rating Scale was used to assess retrospectively childhood symptoms of attention-deficit hyperactivity disorder (ADHD). Additional analyses revealed that the dyslexics with a history of many symptoms of ADHD in childhood (high ADHD) accounted for the group differences in P300; the dyslexics with a history of few or no such symptoms (low ADHD) were indistinguishable from the controls at all electrode sites. Furthermore, whereas the low-ADHD dyslexics showed the same hemispheric asymmetry in auditory P300 as did the controls (right > left), auditory P300 was more symmetrically distributed in the high ADHD dyslexics. The results are interpreted as suggesting that a distinct brain organization may characterize dyslexic men with a history of concomitant deficits in attention. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DYSLEXIA
KW  - READING disability
KW  - ATTENTION-deficit hyperactivity disorder
KW  - HUMAN information processing
KW  - BRAIN
KW  - ATTENTION
KW  - attention-deficit hyperactivity disorder
KW  - dyslexia
KW  - event-related potentials
KW  - information processing
KW  - p300
N1  - Accession Number: 11047682; Duncan, Connie C. 1 Rumsey, Judith M. 2 Wilkniss, Sandra M. 1 Denckla, Martha B. 3 Hamburger, Susan D. 2 Odou-Potkin, Martha 1; Affiliation:  1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD  2: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD  3: Kennedy Institute and Johns Hopkins University School of Medicine, Baltimore, MD; Source Info: Jul1994, Vol. 31 Issue 4, p386; Subject Term: DYSLEXIA; Subject Term: READING disability; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: HUMAN information processing; Subject Term: BRAIN; Subject Term: ATTENTION; Author-Supplied Keyword: attention-deficit hyperactivity disorder; Author-Supplied Keyword: dyslexia; Author-Supplied Keyword: event-related potentials; Author-Supplied Keyword: information processing; Author-Supplied Keyword: p300; Number of Pages: 16p; Document Type: Article
L3  - 10.1111/1469-8986.ep11047682
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Robinson, JoAnn L.
AU  - Zahn-Waxler, Carolyn
AU  - Emde, Robert N.
T1  - Patterns of development in early empathic behavior: Environmental and child constitutional influences.
JO  - Social Development
JF  - Social Development
Y1  - 1994/07//
VL  - 3
IS  - 2
M3  - Article
SP  - 125
EP  - 145
SN  - 0961205X
AB  - The second year of life is a period of developmental change and instability in empathic expressions. In this study, we identify specific developmental patterns of global empathy during the second year and investigate maternal style, family environment, and temperamental factors as moderator influences on these patterns of development. The sample consists of 158 children selected from twin pairs whose empathic development had been previously studied at 14 and 20 months of age. Planned comparisons within specific groups (initially high, mid-range, or low empathy) tested the difference between children who changed versus those who remained stable. Maternal style, family climate, and child temperament variables significantly differentiated children among different patterns of development. Child gender was an additional moderator of family influences on development among those children whose empathic responses were initially low. These findings suggest the importance of distinguishing patterns of development based on where in the range of behaviors development is tracked. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILDREN
KW  - CHILD development
KW  - EMPATHY
KW  - TEMPERAMENT
KW  - FAMILIES
KW  - MATRIARCHY
KW  - GENDER
KW  - Empathy
KW  - family climate
KW  - maternal style
KW  - temperament
N1  - Accession Number: 11631112; Robinson, JoAnn L. 1 Zahn-Waxler, Carolyn 2 Emde, Robert N. 3; Affiliation:  1: University of Colorado.  2: National Institute for Mental Health.  3: University of Colorado Health Sciences Center.; Source Info: Jul94, Vol. 3 Issue 2, p125; Subject Term: CHILDREN; Subject Term: CHILD development; Subject Term: EMPATHY; Subject Term: TEMPERAMENT; Subject Term: FAMILIES; Subject Term: MATRIARCHY; Subject Term: GENDER; Author-Supplied Keyword: Empathy; Author-Supplied Keyword: family climate; Author-Supplied Keyword: maternal style; Author-Supplied Keyword: temperament; Number of Pages: 21p; Document Type: Article
L3  - 10.1111/1467-9507.ep11631112
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107021236
T1  - Researching the health of the elderly.
AU  - Maggi S
Y1  - 1994/07//Jul/Aug94
N1  - Accession Number: 107021236. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe. NLM UID: 0414011. 
KW  - Research
KW  - Chronic Disease -- In Old Age
KW  - Dementia
KW  - Osteoporosis
KW  - Immunization
KW  - Home Health Care
KW  - World Health Organization
KW  - Needs Assessment
KW  - Aged
SP  - 26
EP  - 27
JO  - World Health
JF  - World Health
JA  - WORLD HEALTH
VL  - 47
IS  - 4
PB  - World Health Organization
SN  - 0043-8502
AD  - Coordinator, World Health Organization Programme for Research on Aging, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 31b, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-06486-041
AN  - 2006-06486-041
AU  - Snyder, D. Stephen
T1  - Bad Excitations--Good Vibrations.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1994/07//
VL  - 39
IS  - 7
SP  - 754
EP  - 756
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2006-06486-041. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Snyder, D. Stephen; National Institute on Aging, Bethesda, MD, US. Release Date: 20061226. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Neurodegenerative Diseases; Neurons; Neurotoxins. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Reviewed Item: Langston, J. William (Ed); Young, Anne (Ed). Neurotoxins and Neurodegenerative Disease=New York: New York Academy of Sciences, 1992. 385 pp. $125.00; 1992. Page Count: 3. Issue Publication Date: Jul, 1994. 
AB  - Reviews the book, Neurotoxins and Neurodegenerative Disease edited by J. William Langston and Anne Young (1992). This volume is the result of a conference held in May 1991 that was organized by the editors and Richard Heikkila. It is the culmination of efforts to bring together scientists and clinician scientists, each with a unique perspective, but with a common interest in the problem of nerve cell degeneration. This is an attempt to redouble efforts to discover likely mechanisms common to neuronal degeneration and loss of dopaminergic, cholinergic, and serotonergic cell bodies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuronal degeneration
KW  - nerve cell degeneration
KW  - neurodegenerative disease
KW  - neurotoxins
KW  - 1994
KW  - Neurodegenerative Diseases
KW  - Neurons
KW  - Neurotoxins
KW  - 1994
U2  - Langston, J. William (Ed); Young, Anne (Ed). (1992); Neurotoxins and Neurodegenerative Disease; New York: New York Academy of Sciences, 1992. 385 pp. $125.00; 0-89766-695-X (Hardcover); 0-89766-696-8 (Paperback).
DO  - 10.1037/034519
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36160-001
AN  - 2015-36160-001
AU  - Pennypacker, K. R.
AU  - Thai, L.
AU  - Hong, J.-S.
AU  - McMillian, M. K.
T1  - Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/07//
VL  - 14
IS  - 7
SP  - 3998
EP  - 4006
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Pennypacker, K. R., NIEHS, MD 14-06, P.O. Box 12233, Research Triangle Park, NC, US, 27709
N1  - Accession Number: 2015-36160-001. PMID: 8027758 Partial author list: First Author & Affiliation: Pennypacker, K. R.; Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Apoptosis; DNA; Astrocytes; Gliosis; Transcription Factors. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 1994. Publication History: Accepted Date: Jan 13, 1994; Revised Date: Dec 27, 1993; First Submitted Date: Oct 4, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Systemic administration of kainate, a glutamate receptor agonist, caused neuronal death in the CA1 and CA3 fields of the rat hippocampus. In the areas of cell loss, reactive astrocytes increased their expression of an astrocyte-specific protein, glial fibrillary acidic protein (GFAP). AP-1 DNA binding activity and the expression of a 35 kDa fos-related antigen (fra) remained elevated in the rat hippocampus for at least 2 weeks after a single systemic injection of kainate, which correlated with changes in gene expression during reactive gliosis. lmmunoreactivity for fras was detected in the nuclei of neurons in the dentate gyrus, but relatively few cells in CA1 and CA3 were immunoreactive 1 week after kainate treatment. However, elevated AP-1 DNA binding activity was observed in the CA1 and CA3 regions as well as in the dentate gyrus, suggesting that proteins other than the fras were involved in the astrocytic AP-1 complex. The AP-1 DNA binding activity in hippocampus recognized an AP-1 sequence from the promotor region of the GFAP gene, suggesting that GFAP is a potential target gene. Thus, a single systemic injection of kainate causes long-term activation of AP-1 DNA binding activity in the rat hippocampus and may be important for long-term changes in gene expression in hippocampal cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - fos-related antigen
KW  - jun
KW  - cell death
KW  - gliosis
KW  - reactive astrocyte
KW  - DNA binding activity
KW  - 1994
KW  - Apoptosis
KW  - DNA
KW  - Astrocytes
KW  - Gliosis
KW  - Transcription Factors
KW  - Rats
KW  - 1994
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DB  - psyh
ER  - 

TY  - JOUR
AU  - Stein, Daniel S.
AU  - Graham, Neil M. H.
AU  - Park, Lawrence P.
AU  - Hoover, Donald R.
AU  - Phair, John P.
AU  - Detels, Roger
AU  - Ho, Monto
AU  - Saah, Alfred J.
T1  - The Effect of the Interaction of Acyclovir with Zidovudine on Progression to AIDS and Survival.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1994/07/15/
VL  - 121
IS  - 2
M3  - Article
SP  - 100
EP  - 108
SN  - 00034819
AB  - Objective: To examine the effect of acyclovir use on disease progression and survival in human immunodeficiency virus (HIV)-seropositive persons treated with zidovudine. Setting: Four university-based or -affiliated clinics. Design: Prospective cohort study of homosexual and bisexual men with semi-annual follow-up. Intent-to-treat Cox models were fit to determine the relation between the use of acyclovir (modeled as a time-dependent covariate) and disease progression, controlling for baseline and time-dependent clinical and laboratory prognostic variables. The acquired immunodeficiency syndrome (AIDS)-free duration and survival time were calculated from the first use of zidovudine. Analysis included study visits 7 to 17 (from 1987 to 1992). Patients: 786 HIV-seropositive participants in the Multicenter AIDS Cohort Study who began zidovudine therapy before a clinical diagnosis of AIDS; of these, 515 subsequently received acyclovir. Participants were asked at each visit whether they had "used any medication for health reasons not related to AIDS or if they had taken any medication to help fight AIDS or the HIV virus"; 488 patients indicated acyclovir use under either or both questions, and 242 patients indicated only the latter use. Results: The use of acyclovir for any indication was not associated with an effect on progression to AIDS but was associated with a 26% decrease in the risk for death (relative hazard, 0.74; P = 0.07). The use of acyclovir for HIV infection was also not associated with an effect on progression to AIDS but was associated with a 36% decrease in the risk for death (relative hazard, 0.64; P = 0.01). To further investigate these findings, we examined dose, constancy, and timing of acyclovir use. The median daily dose of acyclovir used for HIV infection was between 600 and 800 mg. No apparent dose effect on survival was found. Longer uninterrupted use of acyclovir for any indication was associated with an 18% decrease in the risk for death for three or more consecutive visits (relative hazard, 0.82; P = 0.23), a 28% decrease for four or more consecutive visits (relative hazard, 0.72; P = 0.09), and a 7% decrease per visit based on the cumulative number of visits while the patient received acyclovir (relative hazard, 0.93 per visit increase; P = 0.03). Use of acyclovir for any indication and use of acyclovir for HIV infection were each associated with a 44% decreased probability of death if the drug was used after AIDS developed (P = 0.007 and P = 0.005, respectively) but not before. To further investigate the prolongation of survival, two landmark analyses were done. The first analysis began at a landmark of 1 year after initiation of zidovudine therapy and compared three groups of patients: those who used acyclovir at or before this landmark, those who had never started acyclovir or started the drug after the landmark, and those who had never used acyclovir. The 90% survival times were 1325,1059, and 982 days, respectively. The second analysis began at a landmark of developing either a CD4 count less than 50 cells/μL or clinical AIDS. The 90% survival times for the three groups were 398,261, and 176 days, respectively. Conclusions: Our analysis suggests that consistent use of acyclovir at a dose sufficient to suppress herpetic recurrences (that is, 600 to 800 mg/d) has a clinically significant effect on prolonging survival in a well-characterized cohort with extensive previous exposure to her-pesvirus infections. Further clinical investigation of low-dose acyclovir with concomitant antiretroviral therapy is warranted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease) -- Treatment
KW  - AZT (Drug)
KW  - ACYCLOVIR
KW  - ANTIVIRAL agents
KW  - DRUG interactions
N1  - Accession Number: 6979358; Stein, Daniel S. 1,2,3,4,5 Graham, Neil M. H. 1,2,3,4,5,6 Park, Lawrence P. 1,2,3,4,5,6 Hoover, Donald R. 1,2,3,4,5,6 Phair, John P. 1,2,3,4,5,7 Detels, Roger 1,2,3,4,5,8 Ho, Monto 1,2,3,4,5,6,9 Saah, Alfred J. 6; Affiliation:  1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland  2: Johns Hopkins University School of Hygiene and Public Health and the Johns Hopkins School of Medicine, Baltimore, Maryland  3: Northwestern University, Chicago, Illinois  4: University of California, Los Angeles, Los Angeles, California  5: University of Pittsburgh, Pittsburgh, Pennsylvania  6: Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, 624 North Broadway, Baltimore, Maryland 21205  7: Division of Infectious Diseases, Northwestern University, Suite 1106, 680 North Lakeshore Drive, Chicago, Illinois 60611  8: Department of Epidemiology, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90024  9: Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15261; Source Info: 7/15/94, Vol. 121 Issue 2, p100; Subject Term: AIDS (Disease) -- Treatment; Subject Term: AZT (Drug); Subject Term: ACYCLOVIR; Subject Term: ANTIVIRAL agents; Subject Term: DRUG interactions; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 8599
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Altuvia, Shoshy
AU  - Almirón, Marta
AU  - Huisman, Gjalt
AU  - Kolter, Roberto
AU  - Storz, Gisela
T1  - The dps promoter is activated by OxyR during growth and by IHF and σS in stationary phase.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1994/07/15/
VL  - 13
IS  - 2
M3  - Article
SP  - 265
EP  - 272
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Dps is a non-specific DNA-binding protein abundant in starved <em>Escherichia coli</em> cells and is important for the defence against hydrogen peroxide. We found that <em>dps</em> mRNA Ievels are controlled by <em>rpoS</em>-encoded σS, the transcriptional activator OxyR and the histone-like IHF protein, in exponentially growing cells, <em>dps</em> is induced by treatment with hydrogen peroxide in an OxyR-dependent manner. This OxyR-dependent induction occurs only during log phase, although the OxyR protein is present in stationary phase, in the stationary phase cells, <em>dps</em> is expressed in a σS- and IHF-dependent manner. The purified OxyR and IHF proteins are also shown to bind upstream of the <em>dps</em> promoter. Our results suggest that the <em>dps</em> promoter is recognized by both σ70-holoenzyme and σS-holoenzyme, since OxyR acts through σ70 and the starts of the OxyR- and σS-dependent transcripts are identical. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - DNA-binding proteins
KW  - Proteins
KW  - Leucine zippers
KW  - NF-kappa B (DNA-binding protein)
KW  - p53 protein
KW  - Hydrogen peroxide
KW  - Messenger RNA
N1  - Accession Number: 15945928; Altuvia, Shoshy 1; Almirón, Marta 2,3; Huisman, Gjalt 2; Kolter, Roberto 2; Storz, Gisela 1; Email Address: STORZ@HELIX.NIH.GOV; Affiliations: 1: Cell Biology and Metabolism Branch, National institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; 3: Departamento de Bacteriologia, Instituto Nacional de Microbiologia 'Carlos G. Malbran', 1281 Buenos Aires, Argentina; Issue Info: Jul1994, Vol. 13 Issue 2, p265; Thesaurus Term: Escherichia coli; Subject Term: DNA-binding proteins; Subject Term: Proteins; Subject Term: Leucine zippers; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: p53 protein; Subject Term: Hydrogen peroxide; Subject Term: Messenger RNA; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 7 Diagrams, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Atkinson, Richard L.
AU  - Hubbard, Van S.
T1  - Report on the NIH Workshop on Pharmacologic Treatment of Obesity.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/08//
VL  - 60
IS  - 2
M3  - Article
SP  - 153
EP  - 156
SN  - 00029165
AB  - A National Institutes of Health workshop on pharmacologic treatment of obesity concluded that pharmacologic agents may be effective in reducing body weight over an extended period of time. Drugs should be used as only one component of a comprehensive weight-reduction program, and additional research is needed on the long-term efficacy and safety of drugs for obesity, and especially for combinations of drugs. Improvement in comorbidities and risk factors of obesity should be used along with weight reduction as an outcome measure in clinical trials. Industry, professional societies, and governmental agencies should work together to explore the potential for drugs for obesity and to reassess the regulatory and administrative controls on the use of currently available drugs for obesity and on the approval process for future drugs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Obesity -- Complications
KW  - Obesity -- Risk factors
KW  - Obesity -- Treatment
KW  - Weight loss
KW  - adrenergic agents
KW  - drugs
KW  - Food and Drug Administration
KW  - Obesity
KW  - obesity complications
KW  - pharmacologic agents
KW  - serotoninergic agents
KW  - sympathetic nervous system
KW  - weight loss
KW  - United States. Food & Drug Administration
KW  - National Institutes of Health (U.S.)
N1  - Accession Number: 94426439; Atkinson, Richard L. 1,2,3; Hubbard, Van S. 1,2,3; Affiliations: 1: Department of Medicine, University of Wisconsin, Madison; 2: Department of Nutritional Sciences, University of Wisconsin, Madison; 3: Nutritional Sciences Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; Issue Info: Aug1994, Vol. 60 Issue 2, p153; Subject Term: Obesity -- Complications; Subject Term: Obesity -- Risk factors; Subject Term: Obesity -- Treatment; Subject Term: Weight loss; Author-Supplied Keyword: adrenergic agents; Author-Supplied Keyword: drugs; Author-Supplied Keyword: Food and Drug Administration; Author-Supplied Keyword: Obesity; Author-Supplied Keyword: obesity complications; Author-Supplied Keyword: pharmacologic agents; Author-Supplied Keyword: serotoninergic agents; Author-Supplied Keyword: sympathetic nervous system; Author-Supplied Keyword: weight loss ; Company/Entity: United States. Food & Drug Administration ; Company/Entity: National Institutes of Health (U.S.); Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hallfrisch, Judith
AU  - Muller, Denis C.
AU  - Singh, Vishwa N.
T1  - Vitamin A and E intakes and plasma concentrations of retinol, β-carotene, and α-tocopherol in men and women of the Baltimore Longitudinal Study of Aging.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/08//
VL  - 60
IS  - 2
M3  - Article
SP  - 176
EP  - 182
SN  - 00029165
AB  - Antioxidants have been linked to protection against degenerative diseases associated with aging. Plasma concentrations were determined for and 7-d diet records collected from 200 women and 231 men aged 20-95 y who took part in the Baltimore Longitudinal Study of Aging. Men consumed more vitamin A from animal and less from vegetable sources than did women. These sex differences are reflected in plasma concentrations of retinol and β-carotene. About 20% of subjects had vitamin A intakes less than recommended dietary allowances; however, no men and only two women had marginal plasma retinol (< 0.35 µmol/L) concentrations. Older people had higher plasma α-tocopherol, which correlated with total intake. Forty-two men and 35 women had plasma α-tocopherol concentrations that were considered marginal. Sex differences in sources of dietary and plasma vitamin A may have consequences in relation to aging and longevity. Apparent marginal intakes and plasma concentrations of vitamin E need to be further examined to determine effects on health status. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Food consumption
KW  - HEALTH
KW  - Vitamin A in human nutrition
KW  - Vitamin E in the blood
KW  - Women
KW  - Baltimore (Md.)
KW  - aging
KW  - antioxidants
KW  - carotene
KW  - Retinol
KW  - tocopherol
KW  - vitamin intake
N1  - Accession Number: 94426447; Hallfrisch, Judith 1; Muller, Denis C. 2; Singh, Vishwa N. 3; Affiliations: 1: Beltsville Human Nutrition Research Center, Beltsville, MD; 2: Gerontology Research Center, National Institute on Aging, NIH, Baltimore; 3: Hoffmann-La Roche, Nutley, NJ; Issue Info: Aug1994, Vol. 60 Issue 2, p176; Thesaurus Term: Food consumption; Thesaurus Term: HEALTH; Subject Term: Vitamin A in human nutrition; Subject Term: Vitamin E in the blood; Subject Term: Women; Subject: Baltimore (Md.); Author-Supplied Keyword: aging; Author-Supplied Keyword: antioxidants; Author-Supplied Keyword: carotene; Author-Supplied Keyword: Retinol; Author-Supplied Keyword: tocopherol; Author-Supplied Keyword: vitamin intake; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Insull Jr, William
AU  - Silvers, Abraham
AU  - Hicks, Linda
AU  - Probstfield, Jeffrey L.
T1  - Plasma lipid effects of three common vegetable oils in reduced-fat diets of free-living adults.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/08//
VL  - 60
IS  - 2
M3  - Article
SP  - 195
EP  - 202
SN  - 00029165
AB  - We compared plasma lipid changes due to the polyunsaturated fatty acids (PUFAs) in partially hydrogenated soybean oil, corn oil, and sunflower oil fed in reduced-fat diets (22-26% of total energy). Each oil was the dominant fat in isoenergetic diets of centrally prepared foods consumed by 26 male and 35 female normolipidemic, free-living individuals. Test diets were consumed double-blind, alternating with self-selected diets for 5 wk each. The ranges of proportions of total fat were: 4.7-9.7% polyunsaturated fat, 8.914.2% monounsaturated fat and 5.4-7.4% saturated fat. All three diets lowered (P < 0.0001) total cholesterol (11 %), LDL cholesterol (13%), and HDL cholesterol (10%), without triglyceride changes. We conclude that PUFAs at ≈6% of total energy result in clinically relevant plasma cholesterol-lowering and that the proportion of polyunsaturated fat must be an important consideration when planning reduced-fat, reduced-saturated-fat diets. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH
KW  - Food consumption
KW  - Saturated fatty acids in human nutrition
KW  - Older women
KW  - Blood cholesterol
KW  - Low-fat diet
KW  - Dietary fats
KW  - fatty acids
KW  - lipoproteins
KW  - monounsaturated fatty acids
KW  - phytosterol
KW  - polyunsaturated fatty acids
KW  - reduced-fat diets
KW  - trans fatty acid
KW  - unsaturated fatty acids
N1  - Accession Number: 94426454; Insull Jr, William 1,2,3; Silvers, Abraham 1,2,3; Hicks, Linda 1,2,3; Probstfield, Jeffrey L. 1,2,3; Affiliations: 1: Lipid Research Clinic, Department of Medicine, Baylor College of Medicine/The Methodist Hospital, Houston, TX; 2: Electric Power Research Institute, Palo Alto, CA; 3: Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute. Bethesda, MD; Issue Info: Aug1994, Vol. 60 Issue 2, p195; Thesaurus Term: HEALTH; Thesaurus Term: Food consumption; Subject Term: Saturated fatty acids in human nutrition; Subject Term: Older women; Subject Term: Blood cholesterol; Subject Term: Low-fat diet; Author-Supplied Keyword: Dietary fats; Author-Supplied Keyword: fatty acids; Author-Supplied Keyword: lipoproteins; Author-Supplied Keyword: monounsaturated fatty acids; Author-Supplied Keyword: phytosterol; Author-Supplied Keyword: polyunsaturated fatty acids; Author-Supplied Keyword: reduced-fat diets; Author-Supplied Keyword: trans fatty acid; Author-Supplied Keyword: unsaturated fatty acids; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
AU  - Lee-Chen Yong
AU  - Formern, Michele R.
AU  - Beecher, Gary R.
AU  - Graubard, Barry I.
AU  - Campbell, William S.
AU  - Reichman, Marsha E.
AU  - Taylor, Philip R.
AU  - Lanza, Elaine
AU  - Holden, Joanne M.
AU  - Judd, Joseph T.
T1  - Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition database.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/08//
VL  - 60
IS  - 2
M3  - Article
SP  - 223
EP  - 230
SN  - 00029165
AB  - The diet-plasma relationships for carotenoids were examined in a group of 98 nonsmoking premenopausal women who participated in the cross-sectional phase of the National Cancer Institute (NCI)-US Department of Agriculture (USDA) diet study on alcohol-hormone metabolism, 1988-90. With use of the newly developed USDA-NCI carotenoid food-composition database, the mean daily intakes of carotenoids were significantly higher when estimated from the food-frequency questionnaire (FFQ) than from the 7-d diet records. Ly-copene (... = 0.58 mmol/L), lutein plus zeaxanthin (... = 0.46 mmol/L), and β-carotene (... = 0.34 mmol/L) were the major plasma carotenoids. After adjustment for body mass index, energy and alcohol intakes, and total plasma cholesterol concentration, the following significant correlations (P < 0.05) were observed between the diet record and the FFQ-estimated carotenoid intakes and their respective plasma concentrations: α-carotene (r = 0.58 vs 0.49), β-carotene (r = 0.51 vs 0.49), ß-cryptoxanthin (r = 0.49 vs 0.36), lutein plus zeaxanthin (r = 0.31 vs 0.37), lycopene (r = 0.50 vs 0.26), and total carotenoids (r = 0.57 vs 0.49). These data indicate that plasma carotenoid concentrations are reflective of dietary intake, but the magnitude of the correlation varies depending on the specific carotenoid and on the dietary assessment tool. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Food consumption
KW  - HEALTH
KW  - Carotene in the blood
KW  - Women
KW  - Perimenopause
KW  - Carotenoids
KW  - dietary assessment
KW  - plasma
KW  - United States. Dept. of Agriculture
KW  - National Cancer Institute (U.S.)
N1  - Accession Number: 94426465; Lee-Chen Yong 1,2; Formern, Michele R. 1,2; Beecher, Gary R. 1,2; Graubard, Barry I. 1,2; Campbell, William S. 1,2; Reichman, Marsha E. 1,2; Taylor, Philip R. 1,2; Lanza, Elaine 1,2; Holden, Joanne M. 1,2; Judd, Joseph T. 1,2; Affiliations: 1: Cancer Prevention Studies Branch and the Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Rockville, MD; 2: Beltsville Human Nutrition Research Center, Agriculture Research Service Center, US Department of Agriculture, Beltsville, MD; Issue Info: Aug1994, Vol. 60 Issue 2, p223; Thesaurus Term: Food consumption; Thesaurus Term: HEALTH; Subject Term: Carotene in the blood; Subject Term: Women; Subject Term: Perimenopause; Author-Supplied Keyword: Carotenoids; Author-Supplied Keyword: dietary assessment; Author-Supplied Keyword: plasma ; Company/Entity: United States. Dept. of Agriculture ; Company/Entity: National Cancer Institute (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - NEWS
AU  - Riley, Matilda White
T1  - Changing Lives and Changing Social Structures: Common Concerns of Social Science and Public Health.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/08//
VL  - 84
IS  - 8
M3  - Editorial
SP  - 1214
EP  - 1214
PB  - American Public Health Association
SN  - 00900036
AB  - This article comments on how the interchange between social science and public health has improved people's lives in the U.S. Epidemiological models to wide-ranging explorations of how particular societal conditions and changes influence aging have been adapted. It rapidly became clear that members of cohorts already old differed markedly from those not yet old. Cohort differences in lives not only reflect the social changes of the past, they also call for present and future social interventions to improve these lives.
KW  - PUBLIC health -- United States
KW  - SOCIAL sciences
KW  - AGING
KW  - SOCIAL change
KW  - QUALITY of life
KW  - UNITED States
N1  - Accession Number: 9409062798; Riley, Matilda White 1; Affiliation:  1: Senior Social Scientist, National Institute on Aging, Bethesda, Md.; Source Info: Aug1994, Vol. 84 Issue 8, p1214; Subject Term: PUBLIC health -- United States; Subject Term: SOCIAL sciences; Subject Term: AGING; Subject Term: SOCIAL change; Subject Term: QUALITY of life; Subject Term: UNITED States; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 4p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Warren, Joan L.
AU  - Bacon, W. Edward
AU  - Harris, Tamara
AU  - McBean, A. Marshall
AU  - Foley, Daniel J.
AU  - Phillips, Caroline
T1  - The Burden and Outcomes Associated with Dehydration among US Elderly, 1991.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/08//
VL  - 84
IS  - 8
M3  - Article
SP  - 1265
EP  - 1265
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Dehydration has been underappreciated as a cause of hospitalization and increased hospital-associated mortality in older people. This study used national data to analyze the burden and outcomes following hospitalizations with dehydration in the elderly. Methods. Data from 1991 Medicare files were used to calculate rates of hospitalization with dehydration, to examine demographic characteristics and concomitant diagnoses associated with dehydration, and to analyze the contribution of dehydration to mortality. Results. In 1991, 6.7% (731 695) of Medicare hospitalizations had dehydration listed as one of the five reported diagnoses, a rate of 236.2/ 10 000 elderly Medicare beneficiaries. In 1991, Medicare reimbursed over $446 million for hospitalizations with dehydration as the principal diagnosis. Older people, men, and Blacks had elevated risks for hospitalization with dehydration. Acute infections, such as pneumonia and urinary tract infections, were frequent concomitant diagnoses. About 50% of elderly Medicare beneficiaries hospitalized with dehydration died within a year of admission. Conclusions. Hospitalization of elderly people with dehydration is a serious and costly medical problem. Attention should be focused on understanding predisposing factors and devising strategies for prevention. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEHYDRATION (Physiology)
KW  - OLDER people -- Diseases
KW  - OLDER people -- Hospital care
KW  - HOSPITAL care
KW  - PNEUMONIA
KW  - URINARY tract infections
N1  - Accession Number: 9409062807; Warren, Joan L. 1 Bacon, W. Edward 2 Harris, Tamara 3 McBean, A. Marshall 1 Foley, Daniel J. 3 Phillips, Caroline 3; Affiliation:  1: Epidemiology Branch, Office of Research, Health Care Financing Administration, Baltimore, Md.  2: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md.  3: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Md.; Source Info: Aug1994, Vol. 84 Issue 8, p1265; Subject Term: DEHYDRATION (Physiology); Subject Term: OLDER people -- Diseases; Subject Term: OLDER people -- Hospital care; Subject Term: HOSPITAL care; Subject Term: PNEUMONIA; Subject Term: URINARY tract infections; Number of Pages: 5p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dwyer, Johanna T.
AU  - Madans, Jennifer H.
AU  - Turnbull, Barry
AU  - Cornoni-Huntley, Joan
AU  - Dresser, Connie
AU  - Everett, Donald F.
AU  - Perrone, Ronald D.
T1  - Diet, Indicators of Kidney Disease, and Later Mortality among Older Persons in the NHANES I Epidemiologic Follow-Up Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/08//
VL  - 84
IS  - 8
M3  - Article
SP  - 1299
EP  - 1299
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The purpose of this study was lo determine whether diet adversely affected survival among 2572 older persons with indicators of kidney disease in a population-based cohort. Average follow-up time for survivors, of whom 1453 (57%) had died at analysis, was 14.5 years. Methods. Kidney disease indicators were a "yes" response to "Has a doctor ever told you that you have kidney disease or renal stones?" and/or trace or greater amounts of protein in urine. Dietary protein intakes were calculated from 24-hour recalls. Results. Cox proportional hazards models were used, stratified by sex. with age, body mass index, blood pressure, education, smoking status. total caloric intake, and diabetes mellitus as covariates. Relative risk of total mortality with an additional 15 g of protein per day was 1.25 (95% confidence interval [CI] = 1.0% 1.42) among White men with kidney disease indicators, vs 1.00 (95% CI = 0.95, 1.06) among those without them; relative risks of renal-related mortality were 1.32 (95% CI = 0.97, 1.79) and 0.95 (95% CI = 0.81, 1.11), respectively. No significant differences were found for White women. Conclusions. Once chronic renal disease is present, diet may be associated with earlier mortality in White males. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KIDNEY diseases
KW  - OLDER people -- Diseases
KW  - MEDICAL care for the aged
KW  - PROTEINS in human nutrition
KW  - WHITE men
KW  - DISEASES
N1  - Accession Number: 9409062813; Dwyer, Johanna T. 1,2,3 Madans, Jennifer H. 4 Turnbull, Barry 5 Cornoni-Huntley, Joan 6 Dresser, Connie 7 Everett, Donald F. 8 Perrone, Ronald D. 9,10; Affiliation:  1: Tufts University Medical School, Boston, Mass  2: Frances Stern Nutrition Center, New England Medical Center Hospitals, Boston, Mass  3: US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University  4: Division of Analysis, National Center for Health Statistics, Hyattsville, Md.  5: Alkermes, Cambridge, Mass.  6: National Institute on Aging, Bethesda, Md.  7: Public Health Applications Research Branch, National Cancer Institute, Rockville, Md.  8: Collaborative Clinical Research Branch, National Eye Institute, Bethesda, Md.  9: Tufts University Medical School  10: Division of Nephrology, New England Medical Center Hospitals; Source Info: Aug1994, Vol. 84 Issue 8, p1299; Subject Term: KIDNEY diseases; Subject Term: OLDER people -- Diseases; Subject Term: MEDICAL care for the aged; Subject Term: PROTEINS in human nutrition; Subject Term: WHITE men; Subject Term: DISEASES; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Berman, C. M.
AU  - Rasmussen, K. L. R.
AU  - Suomi, Stephen J.
T1  - Responses of Free-ranging Rhesus Monkeys to a Natural Form of Social Separation.  I. Parallels with Mother-Infant Separation in Captivity.
JO  - Child Development
JF  - Child Development
Y1  - 1994/08//
VL  - 65
IS  - 4
M3  - Article
SP  - 1028
EP  - 1041
PB  - Wiley-Blackwell
SN  - 00093920
AB  - Observations of 23 free-ranging rhesus monkey infants on Cayo Santiago, Puerto Rico, indicated that mothers' first postpartum estrous periods were marked by large increases in the amount of time infants were separated from their mothers, by disturbances in mother-infant relationships, and by increases in infant distress behavior. When their mothers resumed mating, most infants showed signs of agitation; a few briefly showed indications of depression. Male infants responded to their mothers' resumption of mating by playing more, whereas females engaged in less play and more allogrooming. The results suggest (<em>a</em>) that basic parallels exist between the behavioral responses of rhesus infants to their mothers' resumption of mating in the field and to forcible separation from their mothers in captivity and (<em>b</em>) that early separation experiences may play a role in the normal development or manifestation of sex differences in behavior. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOTHER & infant
KW  - RHESUS monkey
KW  - MOTHER & child
KW  - BEHAVIOR
KW  - DISTRESS (Psychology)
KW  - SEX differences (Biology)
N1  - Accession Number: 7252715; Berman, C. M. 1 Rasmussen, K. L. R. 2 Suomi, Stephen J. 2; Affiliation:  1: State University of New York at Buffalo.  2: National Institute of Child Health and Human Development.; Source Info: Aug1994, Vol. 65 Issue 4, p1028; Subject Term: MOTHER & infant; Subject Term: RHESUS monkey; Subject Term: MOTHER & child; Subject Term: BEHAVIOR; Subject Term: DISTRESS (Psychology); Subject Term: SEX differences (Biology); Number of Pages: 14p; Document Type: Article
L3  - 10.1111/1467-8624.ep7252715
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107181793
T1  - A quick, practical antismoking program for your practice.
AU  - Epps RP
AU  - Manley MW
Y1  - 1994/08//1994 Aug
N1  - Accession Number: 107181793. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8702030. 
KW  - Passive Smoking -- Prevention and Control -- In Infancy and Childhood
KW  - Smoking -- Prevention and Control -- In Infancy and Childhood
KW  - Smoking -- Prevention and Control -- In Adolescence
KW  - Smoking -- Prevention and Control -- In Adulthood
KW  - Child, Preschool
KW  - Infant
KW  - Infant, Newborn
KW  - Child
KW  - Adolescence
KW  - Adult
SP  - 24
EP  - 32
JO  - Contemporary Pediatrics
JF  - Contemporary Pediatrics
JA  - CONTEMP PEDIATR
VL  - 11
IS  - 8
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Pediatricians are in a unique position to help snuff out the epidemic of tobacco use among young people. This easy-to-use, five-point program will help you focus your counseling efforts.
SN  - 8750-0507
AD  - Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Suomi, Stephen J.
T1  - Stone-Tool Bone-Surface Modification by Monkeys.
JO  - Current Anthropology
JF  - Current Anthropology
Y1  - 1994/08//Aug-Oct94
VL  - 35
IS  - 4
M3  - Article
SP  - 468
EP  - 470
SN  - 00113204
AB  - The article determines whether monkeys could produce the types of stone-tool bone-surface modifications attributed to the activities of early hominids. The authors used 10 capuchin monkeys with stones and bone fragments as subjects to test their ability to deflesh bones using stone tools. The study found that the use of stones to deflesh bone fragments by these capuchins produced bone-surface modification which contrasted to the use of tools by early hominids. These results suggest that capuchins may be used to model the functional processes that facilitated the origins of human technology.
KW  - CAPUCHIN monkeys
KW  - STONE implements
KW  - TOOLS
KW  - STONE
KW  - HOMINIDS
KW  - ANTHROPOLOGICAL research
KW  - HUMAN geography
KW  - ANIMALS & civilization
KW  - HUMAN-animal relationships
N1  - Accession Number: 9411103355; Westergaard, Gregory Charles 1 Suomi, Stephen J. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, National Institutes of Health Animal Center, P.O. Box 529, Poolesville, MD 20837, U.S.A.; Source Info: Aug-Oct94, Vol. 35 Issue 4, p468; Subject Term: CAPUCHIN monkeys; Subject Term: STONE implements; Subject Term: TOOLS; Subject Term: STONE; Subject Term: HOMINIDS; Subject Term: ANTHROPOLOGICAL research; Subject Term: HUMAN geography; Subject Term: ANIMALS & civilization; Subject Term: HUMAN-animal relationships; NAICS/Industry Codes: 327991 Cut Stone and Stone Product Manufacturing; NAICS/Industry Codes: 444190 Other Building Material Dealers; NAICS/Industry Codes: 423320 Brick, Stone, and Related Construction Material Merchant Wholesalers; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; Number of Pages: 3p; Illustrations: 1 Black and White Photograph, 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107428476
T1  - The 1993 Kent Lecture. Aging and society: past, present, and future.
AU  - Riley MW
Y1  - 1994/08//
N1  - Accession Number: 107428476. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0375327. 
KW  - Aging -- Psychosocial Factors
KW  - Culture -- Trends
KW  - Program Development
KW  - Forecasting
KW  - History of Medicine
KW  - Research
KW  - Social Change
KW  - Paradigms
KW  - Aged
SP  - 436
EP  - 446
JO  - Gerontologist
JF  - Gerontologist
JA  - GERONTOLOGIST
VL  - 34
IS  - 4
PB  - Oxford University Press / USA
SN  - 0016-9013
AD  - National Institute on Aging, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 7959099.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - RPRT
AU  - Kim, In-Gyu
AU  - Lee, Seung-Chul
AU  - Lee, Jeung-Hoon
AU  - Yang, Jun-Mo
AU  - Chung, Soo-Il
AU  - Steinert, Peter M.
T1  - Structure and Organization of the Human Transglutaminase 3 Gene: Evolutionary Relationship to the Transglutaminase Family.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/08//
VL  - 103
IS  - 2
M3  - Report
SP  - 137
EP  - 142
SN  - 0022202X
AB  - The human haploid genome contains a family of at least five different transglutaminases that are differentially expressed in time- and tissue-specific ways. Of these, transglutaminase 3 (TGase3) is unusual in that it is a pro-enzyme requiring activation by proteolysis. To date it is known to be expressed only in terminally differentiating epidermal and hair follicle keratinocytes. In this paper we show that it is encoded by a gene (TGM3) of 42.8 kbp containing 13 exons. In the course of isolation of genomic clones for the TGM3 gene, we also found clones encoding the widely expressed tissue or TGase2 enzyme, perhaps due to high degrees of sequence homology. The structure of the TGM2 gene has not yet been reported. Our incomplete data suggest its exon/intron organization is very similar to that of TGM3. Although the common intron splice points of all members of the transglutaminase gene family have been conserved, the TGM3 and TGM2 genes, and the gene for the subplasma membrane transglutaminaselike protein band 4.2, lack two introns found in the TGM1 and factor XIIIa genes, and the exact intron splice point of another intron is shifted with respect to that of the TGM1 and factor XIIIa genes. Based on sequence homologies and gene structures, the data support a phylogenic tree in which the TGM2 and TGM3 genes belong on a branch distinct from other transglutarninases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSGLUTAMINASES
KW  - HAPLOIDY
KW  - GENOMES
KW  - KERATINOCYTES
KW  - TRANSFERASES
KW  - EPIDERMIS
KW  - HAIR follicles
KW  - <em>cell envelope</em>
KW  - <em>keratinization</em>
KW  - <em>transglutaminase 2</em>
N1  - Accession Number: 12392470; Kim, In-Gyu 1 Lee, Seung-Chul Lee, Jeung-Hoon Yang, Jun-Mo Chung, Soo-Il Steinert, Peter M. 1; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, U.S.A.; Source Info: Aug94, Vol. 103 Issue 2, p137; Subject Term: TRANSGLUTAMINASES; Subject Term: HAPLOIDY; Subject Term: GENOMES; Subject Term: KERATINOCYTES; Subject Term: TRANSFERASES; Subject Term: EPIDERMIS; Subject Term: HAIR follicles; Author-Supplied Keyword: <em>cell envelope</em>; Author-Supplied Keyword: <em>keratinization</em>; Author-Supplied Keyword: <em>transglutaminase 2</em>; Number of Pages: 6p; Document Type: Report
L3  - 10.1111/1523-1747.ep12392470
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Plott, R. Todd
AU  - Amagai, Masayuki
AU  - Udey, Mark C.
AU  - Stanley, John R.
T1  - Pemphigus Vulgaris Antigen Lacks Biochemical Properties Characteristic of Classical Cadherins.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/08//
VL  - 103
IS  - 2
M3  - Article
SP  - 168
EP  - 172
SN  - 0022202X
AB  - Pemphigus vulgaris antigen (PVA) is a member of the desmoglein subfamily of the cadherin supergene family. PVA has homology to the classical cadherins (e.g., E-cadherin), both in its extracellular and cytoplasmic domains. Classical cadherins possess certain well-defined and characteristic biochemical properties of both domains. The cytoplasmic domain binds α-, β-, and γ-catenins. The extracellular domain is protected by calcium from degradation by trypsin. In this study we show that PVA does not share these characteristic biochemical features. Immunoprecipitation of E-cadherin and PVA from human keratinocytes shows that under the same conditions in which the catenins co-precipitate with E-cadherin, only plakoglobin (which co-migrates with γ-catenin) co-precipitates with PVA. Treatment of keratinocytes with 0.01% trypsin in 1 mM calcium (T/C) does not degrade the extracellular region of E-cadherin, but does partially degrade that of PVA. This increased T/C susceptibility of PVA is not due to its cytoplasmic domain, as the same sensitivity of: the extracellular domain of PVA to T/C was observed in L cell clones transfected with a chimeric cDNA that encoded for the extracellular domain of PVA and the cytoplasmic domain of E-cadherin. These data demonstrate that although the desmogleins and classical cadherins share striking amino acid homologies in both the cytoplasmic and extracellular domains, they do not exhibit identical biochemical properties and, by extension, may not subserve identical cell biologic functions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEMPHIGUS
KW  - KERATINOCYTES
KW  - ANTIGENS
KW  - CYTOPLASM
KW  - TRYPSIN
KW  - SERINE proteinases
KW  - AMINO acids
KW  - <em>catenins</em>
KW  - <em>Desmoglein</em>
KW  - <em>desmosome</em>
KW  - <em>plakoglobin</em>
N1  - Accession Number: 12392642; Plott, R. Todd 1 Amagai, Masayuki 1 Udey, Mark C. 1 Stanley, John R. 1; Affiliation:  1: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug94, Vol. 103 Issue 2, p168; Subject Term: PEMPHIGUS; Subject Term: KERATINOCYTES; Subject Term: ANTIGENS; Subject Term: CYTOPLASM; Subject Term: TRYPSIN; Subject Term: SERINE proteinases; Subject Term: AMINO acids; Author-Supplied Keyword: <em>catenins</em>; Author-Supplied Keyword: <em>Desmoglein</em>; Author-Supplied Keyword: <em>desmosome</em>; Author-Supplied Keyword: <em>plakoglobin</em>; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12392642
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DP  - EBSCOhost
DB  - aph
ER  - 
TY  - JOUR
AU  - Compton, John G.
AU  - Goldstein, Alisa M.
AU  - Turner, Maria
AU  - Bale, Allen E.
AU  - Kearns, Kathleen S.
AU  - McBride, O. Wesley
AU  - Bale, Sherri J.
T1  - Fine Mapping of the Locus for Nevoid Basal Cell Carcinoma Syndrome on Chromosome 9q.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/08//
VL  - 103
IS  - 2
M3  - Article
SP  - 178
EP  - 181
SN  - 0022202X
AB  - The nevoid basal cell carcinoma syndrome is an autosomal dominant disorder characterized primarily by multiple basal cell carcinomas, odontogenic keratocysts, and pits of the palms and soles. Tumor deletion studies and linkage analysis in Caucasians have revealed that the gene is on chromosome 9q. To further refine the location of the nevoid basal cell carcinoma syndrome locus, we tested linkage to this region in three families. Evaluation of recombinants suggested that the nevoid basal cell carcinoma syndrome locus lies in the interval defined distally by D9S127. Our data, together with existing published data defining D9S12 as a proximal flanking marker, refine the location of nevoid basal cell carcinoma syndrome to an 8.3-cM interval. Two of the families studied were African-American and show a notable variation in phenotypic expression in which affected individuals developed few skin cancers. However, despite clinical heterogeneity our data are consistent with the hypothesis that the same locus is involved in these African-American families. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL cell nevus syndrome
KW  - BONES -- Abnormalities
KW  - GENE mapping
KW  - CHROMOSOMES
KW  - BASAL cell carcinoma
KW  - AFRICAN Americans
KW  - <em>basal cell nevus syndrome</em>
KW  - <em>gene mapping</em>
KW  - <em>gorlin syndrome</em>
KW  - <em>linkage analysis</em>
KW  - <em>NBCCS</em>
N1  - Accession Number: 12392682; Compton, John G. 1 Goldstein, Alisa M. 2 Turner, Maria 3 Bale, Allen E. 4 Kearns, Kathleen S. 1 McBride, O. Wesley 5 Bale, Sherri J. 1; Affiliation:  1: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, Maryland, U.S.A.  2: Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland, U.S.A.  3: Dermatology Branch, Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, Bethesda, Maryland, U.S.A.  4: Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, U.S.A.  5: Laboratory of Biochemistry, Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug94, Vol. 103 Issue 2, p178; Subject Term: BASAL cell nevus syndrome; Subject Term: BONES -- Abnormalities; Subject Term: GENE mapping; Subject Term: CHROMOSOMES; Subject Term: BASAL cell carcinoma; Subject Term: AFRICAN Americans; Author-Supplied Keyword: <em>basal cell nevus syndrome</em>; Author-Supplied Keyword: <em>gene mapping</em>; Author-Supplied Keyword: <em>gorlin syndrome</em>; Author-Supplied Keyword: <em>linkage analysis</em>; Author-Supplied Keyword: <em>NBCCS</em>; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12392682
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12392682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105850933
T1  - Occupational cancer among women: a conference overview.
AU  - Pottern LM
AU  - Zahm SH
AU  - Sieber SS
AU  - Schneider IJ
AU  - LaRosa JH
AU  - Brown DP
AU  - Collman GW
AU  - Fingerhut MA
AU  - Waters MA
Y1  - 1994/08//
N1  - Accession Number: 105850933. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Neoplasms
KW  - Occupational Diseases
KW  - Women's Health
KW  - Epidemiological Research
KW  - Female
KW  - Risk Factors
KW  - Women, Working
KW  - Human
SP  - 809
EP  - 813
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - Occupational Studies Section, National Cancer Institute, Bethesda, MD 20892-7364.
U2  - PMID: 7807258.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850933&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850939
T1  - Recent cancer patterns among men and women in the United States: clues for occupational research.
AU  - Devesa SS
AU  - Grauman DJ
AU  - Blot WJ
Y1  - 1994/08//
N1  - Accession Number: 105850939. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Neoplasms -- Mortality
KW  - Occupational Diseases -- Mortality
KW  - Blacks
KW  - Bladder Neoplasms -- Mortality
KW  - Female
KW  - Lung Neoplasms -- Mortality
KW  - Male
KW  - Occupational Health
KW  - United States
KW  - Whites
SP  - 832
EP  - 841
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - Biostatistics Branch, Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892.
U2  - PMID: 7807262.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850939&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850937
T1  - Inclusion of women and minorities in occupational cancer epidemiologic research.
AU  - Zahm SH
AU  - Pottern LM
AU  - Lewis DR
AU  - Ward MH
AU  - White DW
Y1  - 1994/08//
N1  - Accession Number: 105850937. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Epidemiological Research
KW  - Minority Groups
KW  - Neoplasms -- Epidemiology
KW  - Occupational Diseases -- Epidemiology
KW  - Women, Working
KW  - Female
KW  - Male
KW  - Newsletters
KW  - Research
KW  - United States
KW  - Women's Health
KW  - Human
SP  - 842
EP  - 847
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - Occupational Studies Section, National Cancer Institute, Rockville, Maryland 20892-7364.
U2  - PMID: 7807263.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850937&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850938
T1  - Gender differences in animal bioassays for carcinogenicity.
AU  - Griesemer RA
AU  - Eustis SL
Y1  - 1994/08//
N1  - Accession Number: 105850938. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Biological Assay
KW  - Reproduction
KW  - Toxicity Tests
KW  - Animals
KW  - Breast Neoplasms -- Chemically Induced
KW  - Carcinogens
KW  - Female
KW  - Male
KW  - Ovarian Neoplasms -- Chemically Induced
KW  - Uterine Neoplasms -- Chemically Induced
SP  - 855
EP  - 859
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
U2  - PMID: 7807265.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850938&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850944
T1  - Mortality patterns among female and male chrysotile asbestos textile workers.
AU  - Brown DP
AU  - Dement JM
AU  - Okun A
Y1  - 1994/08//
N1  - Accession Number: 105850944. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Asbestos -- Adverse Effects
KW  - Occupational Diseases -- Mortality
KW  - Occupational Diseases
KW  - Textile Industry
KW  - Blacks
KW  - Cause of Death
KW  - Female
KW  - Lung Neoplasms -- Chemically Induced
KW  - Lung Neoplasms -- Mortality
KW  - Male
KW  - Neoplasms -- Chemically Induced
KW  - Neoplasms -- Mortality
KW  - Pneumoconiosis -- Mortality
KW  - Prospective Studies
KW  - Relative Risk
KW  - Retrospective Design
KW  - South Carolina
KW  - Whites
KW  - Women, Working
KW  - Human
SP  - 882
EP  - 888
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - Office of Disease Prevention, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
U2  - PMID: 7807269.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850944&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850952
T1  - Women in the formaldehyde industry: their exposures and their jobs.
AU  - Stewart PA
AU  - Blair A
Y1  - 1994/08//
N1  - Accession Number: 105850952. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Industry
KW  - Occupational Exposure
KW  - Task Performance and Analysis
KW  - Adult
KW  - Female
KW  - Formaldehyde
KW  - Male
KW  - Risk Assessment
KW  - Women's Health
KW  - Women, Working
SP  - 918
EP  - 923
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - Environmental Epidemiology Branch, National Cancer Institute, Rockville, Maryland 20892.
U2  - PMID: 7807276.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850952&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850951
T1  - Occupation and ovarian cancer: a case-control study in the Washington, DC, metropolitan area, 1978-1981.
AU  - Hartge P
AU  - Stewart P
Y1  - 1994/08//
N1  - Accession Number: 105850951. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807. 
KW  - Occupational Diseases -- Epidemiology
KW  - Ovarian Neoplasms -- Epidemiology
KW  - Talc -- Adverse Effects
KW  - Adult
KW  - Aged
KW  - Confidence Intervals
KW  - District of Columbia
KW  - Female
KW  - Hydrocarbons -- Adverse Effects
KW  - Middle Age
KW  - Occupational Diseases -- Etiology
KW  - Occupational Exposure
KW  - Ovarian Neoplasms -- Etiology
KW  - Radiation, Ionizing
KW  - Relative Risk
KW  - Retrospective Design
KW  - Women, Working
KW  - Human
SP  - 924
EP  - 927
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
JA  - J OCCUP MED
VL  - 36
IS  - 8
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0096-1736
AD  - Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD 20892.
U2  - PMID: 7807277.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850951&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-36259-001
AN  - 2015-36259-001
AU  - Gogate, Nitin
AU  - Verma, Lalit
AU  - Zhou, Jia Min
AU  - Milward, Elizabeth
AU  - Rusten, Ray
AU  - O'Connor, Michael
AU  - Kufta, Conrad
AU  - Kim, Jin
AU  - Hudson, Lynn
AU  - Dubois-Dalcq, Monique
T1  - Plasticity in the adult human oligodendrocyte lineage.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/08//
VL  - 14
IS  - 8
SP  - 4571
EP  - 4587
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Dubois-Dalcq, Monique, LVMP, NINDS, NIH, Building 36, Room 5D04, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36259-001. PMID: 7519254 Partial author list: First Author & Affiliation: Gogate, Nitin; Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160808. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Gogate, Nitin. Major Descriptor: Genes; Oligodendrocytes; White Matter; Growth Factor. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Aug, 1994. Publication History: Accepted Date: Jan 4, 1994; Revised Date: Nov 30, 1993; First Submitted Date: Jul 22, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Preoligodendrocytes have been described in cultures and tissue prints of adult human white matter (Armstrong et al., 1992). To characterize further these precursors of human oligodendrocytes, we have investigated whether they express genes playing a critical role in oligodendrocyte development. In the intact human brain, platelet-derived growth factor receptor α (PDGFαR) and myelin transcription factor 1 (MyTI) transcripts are expressed in 1-2% of cells of the oligodendrocyte lineage (OL), and clusters of such cells can be found in the periventricular region. Myelin basic protein transcripts containing exon 2 information (exon 2+ MBP), which are characteristic of the premyelinating stage, are detected in 15-20% of OL cells in vivo. When OL cells are separated from human white matter and allowed to regenerate in vitro, a much larger proportion of these cells express developmentally regulated genes, while exon 2- MBP and proteolipid protein (PLP) transcripts characteristic of mature OL cells appear transiently downregulated. Basic fibroblast growth factor (bFGF), even in the presence of PDGF, does not promote DNA synthesis in these cultured OL cells. Yet bFGF induces human oligodendrocytes to regenerate their processes rapidly in vitro and to express O4 antigens as well as exon 2+ MBP, MyTI, and PLP transcripts. While bFGF accelerates early regenerative processes, it also maintains high expression of exon 2+ MBP transcripts in OL cells for up to 2 weeks in vitro. In contrast, high levels of insulin in the absence of bFGF allow accumulation of exon 2- MBP and PLP transcripts in most OL cells at 2-3 weeks in vitro. We propose that the myelinated human brain harbors a small pool of precursors of oligodendrocytes and that growth factor-regulated phenotypic plasticity rather than mitogenic potential accounts for the regeneration of oligodendrocytes in the initial stages of demyelinating diseases such as multiple sclerosis. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - human brain
KW  - oligodendrocytes
KW  - regeneration
KW  - myelin genes
KW  - developmentally regulated genes PDGFaR and MyTl
KW  - basic fibroblast growth factor
KW  - in situ hybridization
KW  - 1994
KW  - Genes
KW  - Oligodendrocytes
KW  - White Matter
KW  - Growth Factor
KW  - 1994
U1  - Sponsor: Myelin Project, US. Recipients: Gogate, Nitin; Verma, Lalit
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36259-029
AN  - 2015-36259-029
AU  - Brady, Linda S.
AU  - Lynn, Allison B.
AU  - Herkenham, Miles
AU  - Gottesfeld, Zehava
T1  - Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/08//
VL  - 14
IS  - 8
SP  - 4951
EP  - 4964
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Brady, Linda S., Section on Functional Neuroanatomy, National Institute of Mental Health, Building 36, Room 2D15, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36259-029. PMID: 7913957 Partial author list: First Author & Affiliation: Brady, Linda S.; Section on Functional Neuroanatomy, Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20160808. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Interleukins; Histochemistry; mRNA. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Aug, 1994. Publication History: Accepted Date: Feb 17, 1994; Revised Date: Feb 3, 1994; First Submitted Date: Oct 20, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - This study was designed to examine the mechanisms by which systemic interleukin-1 affects neuroenclocrine systems in the brain. lntraperitoneal injections of interleukin-1β (1.25 μg/rat) were administered to rats. One or three hours after injection, the expression levels of the immediate-early gene c-fos and of genes for several neuropeptides, receptors, and enzymes were examined by in situ hybridization histochemistry. In the brainstem at 1 hr, c-fos mRNA was elevated in the area postrema and nucleus of the solitary tract, but not in the locus coeruleus. At 3 hr, the c-fos mRNA levels had increased further in the nucleus of the solitary tract. Rostrally, elevations in c-fos mRNA levels were found in the hypothalamic and thalamic paraventricular nuclei, central nucleus of amygdala, bed nucleus of the stria terminalis, and medial preoptic area, peaking at 1 hr and diminishing at 3 hr. In addition, at 3 hr a new pattern of c-fos activity emerged-the arcuate nucleus and cells at the external margins throughout the brain now expressed c-fos mRNA. Corticotropin- releasing hormone mRNA levels were doubled in the paraventricular nucleus at 1 and 3 hr, concomitant with elevations in plasma adrenocorticotrophic hormone (ACTH) and corticosterone. Tyrosine hydroxylase mRNA levels in the brainstem did not change. The c-fos mRNA induction patterns reveal a temporally dynamic response to interleukin-1 administration. We propose that the early set of structures responding to interleukin-1 initiates the neuroendocrine response to cytokines. Coactivation of the area postrema and nucleus of the solitary tract may reflect entry into the brain and neural transduction of the peripheral signal. The late set-including the nucleus of the solitary tract, arcuate nucleus, and the brain’s edge-may reflect cellular activation along the diffusion routes traveled by interleukin-1 or a bioactive transduction product, because the pattern of edge labeling is similar to the autoradiographic pattern of flow of radiolabeled tracer substances in the cerebrospinal fluid. The late c-fos mRNA response to interleukin-1, therefore, may represent a demonstration of information transfer in the parasynaptic mode, also known as volume transmission. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - interleukin- 1
KW  - c-fos
KW  - paraventricular nucleus
KW  - hypothalamic-pituitary-adrenal (HPA) axis
KW  - limbic system
KW  - area postrema
KW  - nucleus of the solitary tract
KW  - 1994
KW  - Brain
KW  - Interleukins
KW  - Histochemistry
KW  - mRNA
KW  - Rats
KW  - 1994
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Sekul, Elizabeth A.
AU  - Cupler, Edward J.
AU  - Dalakas, Marinos C.
T1  - Aseptic Meningitis Associated with High-Dose Intravenous Immunoglobulin Therapy: Frequency and Risk Factors.
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
Y1  - 1994/08/15/
VL  - 121
IS  - 4
M3  - Article
SP  - 259
EP  - 262
SN  - 00034819
AB  - Objective: Intravenous immunoglobulin is widely used to treat various autoimmune disorders. After observing instances of aseptic meningitis in treated patients, we studied the frequency and associated risk factors for aseptic meningitis in patients treated with high-dose intravenous immunoglobulin. Design: Retrospective analysis of a prospective cohort study. Setting: Tertiary research referral center. Patients: 54 consecutive patients with various immune-related neuromuscular diseases participating in ongoing therapeutic trials of high-dose (2 g/kg) intravenous immunoglobulin. Measurements: Analysis of patient records for evidence of aseptic meningitis, associated risk factors, penetration of serum IgG into the cerebrospinal fluid, and clearance of cerebrospinal fluid IgG. Results: Of 54 patients, 6 (11 %; 95% CI, 4% to 23%) developed aseptic meningitis within 24 hours after completion of the infusions. Symptoms, lasting 3 to 5 days, included severe headache, meningismus, photophobia, and fever. Cerebrospinal fluid showed pleocytosis in 4 patients (leukocyte count as high as 1169 × 10[sup 6]/L in one patient), eosinophilia in 3 patients, and IgG elevation in all patients (as great as 7 times the upper limit of normal in one patient). Repeat cerebrospinal fluid and serum studies after 24 hours showed a 46% cerebrospinal fluid IgG clearance compared with an 11 % clearance of serum IgG in one patient. Cerebrospinal fluid cultures were negative. Aseptic meningitis developed in 4 of 8 patients (50%; CI, 16% to 84%) with a history of migraine but in only 2 of 46 (4%; CI, 0.5% to 15%) patients without such a history (P = 0.003). Aseptic meningitis recurred in patients who had migraine despite the use of different commercial intravenous immunoglobulin preparations and slower rates of infusion. Conclusion: Aseptic meningitis develops in patients receiving high-dose intravenous immunoglobulin therapy. Patients with a history of migraine are more likely to develop aseptic meningitis while receiving intravenous immunoglobulin therapy, regardless of the type of commercial preparation or the infusion rate. Possible inciting factors include the IgG itself, various stabilizing products within each of the preparations, cytokine release triggered by the therapy, or cerebrovascular sensitivity in migraineurs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENINGITIS
KW  - PATIENTS
KW  - CEREBROSPINAL fluid
N1  - Accession Number: 6977647; Sekul, Elizabeth A. 1 Cupler, Edward J. 1 Dalakas, Marinos C. 1; Affiliation:  1: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: 8/15/94, Vol. 121 Issue 4, p259; Subject Term: MENINGITIS; Subject Term: PATIENTS; Subject Term: CEREBROSPINAL fluid; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3455
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Prasad, Gaddarnanugu L.
AU  - Fuldner, Rebecca A.
AU  - Braverman, Richard
AU  - Mcduffie, Elwood
AU  - Cooper, Herbert L.
T1  - Expression, cytoskeletal utilization and dimer formation of tropomyosin derived from retroviral-mediated cDNA transfer.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/08/15/
VL  - 224
IS  - 1
M3  - Article
SP  - 1
EP  - 10
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Expression of the tropomyosin-1 isoform was enhanced by cDNA transfer in non-transformed murine 3T3 fibroblasts and also in v-Ki-ras transformed fibroblasts in which native tropomyosin-1 expression had been reduced and tropomyosin-2 synthesis virtually eliminated by action of the oncogene. The level of synthesis of insert-derived tropomyosin-1 was similar in normal and transformed transductants (3-5 times normal levels). The high level of insert-derived tropomyosin-1 expression resulted in a considerable increase in tropomyosin-1 utilization in the cytoskeleton of transformed cells, but this expression still did not reach normal levels, suggesting an oncogene-related inhibition of tropomyosin utilization. A large proportion of newly synthesized native tropomyosin-1 in normal, unmodified fibroblasts appeared in homodimers which, upon prolonged incubation, were largely converted to the heterodimers. Excess tropomyosin-1 derived from the inserted cDNA also appeared largely as the homodimer in both normal and transformed cells. This homodimer was utilized effectively in the formation of cytoskeletal structures but was partially converted to heterodimer by chain exchange. Under steady-state conditions, approximately 33% of the cytoskeletal tropomyosin-1-containing dimers were homodimers, compared to approximately 10% in normal fibroblasts. The results show that the increased amount of tropomyosin-1 homodimer entering the cytoskeleton under conditions of tropomyosin-1 excess, results in an atypical microfilament composition. The effect of this excess of tropomyosin-1 homodimers on stability or function of microfilament fibers remains to be determined. The results also confirm that the mechanisms of rapid homodimer formation with conversion to heterodimers by chain exchange, known from in vitro studies, also occur in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TROPOMYOSINS
KW  - FIBROBLASTS
KW  - CYTOSKELETAL proteins
KW  - DNA
KW  - ONCOGENES
KW  - MICROFILAMENT proteins
N1  - Accession Number: 12131672; Prasad, Gaddarnanugu L. 1 Fuldner, Rebecca A. 1 Braverman, Richard 1 Mcduffie, Elwood 1 Cooper, Herbert L. 1; Affiliation:  1: Cell and Molecular Physiology Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, USA.; Source Info: 8/15/94, Vol. 224 Issue 1, p1; Subject Term: TROPOMYOSINS; Subject Term: FIBROBLASTS; Subject Term: CYTOSKELETAL proteins; Subject Term: DNA; Subject Term: ONCOGENES; Subject Term: MICROFILAMENT proteins; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tancredi, Teodorico
AU  - Salvadori, Severo
AU  - Amodeo, Pietro
AU  - Picone, Delia
AU  - Lazarus, Lawrence H.
AU  - Bryant, Sharon D.
AU  - Guerrini, Reme
AU  - Marzola, Giuliano
AU  - Temussi, Piero A.
T1  - Conversion of enkephalin and dermphin into δ-selective opioid antagonists by single-residue substitution.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/08/15/
VL  - 224
IS  - 1
M3  - Article
SP  - 241
EP  - 247
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The properties of di- and tri-peptides containing 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in second position suggest that the message domain of opioid peptides can be composed of only two residues (Temussi, P. A., Salvadori, S., Amodeo, P., Guerrini, R., Tomatis, R., Lazarus, L. H., Picone, D. & Tancredi, T. (1994) Biochem. Biophys. Res. Commun. 198, 933-939). As a crucial test of the possibility that the Tyr-Tic segment be a message domain in longer peptide sequences, we have inserted it in the sequences of two typical opioid peptides: (Leu)enkephalin, a non-selective agonist, and dermorphin, a selective μ agonist. Here we report the synthesis and biological activity of (L-Tic[sup2])enkephalin, (L-Tic[sup2])dermorphin, (L-Tic[sup2])dermorphin carboxylic acid and [D-Tic2]dermorphin: all (L-Tic[sup2])peptides were converted from agonists to delta-selective antagonists. The NMR conformational study in a dimethylsulfoxide/water cryoprotective mixture at low temperature shows diagnostic side-chain--side-chain NOEs in the spectra of all (L-Tic[sup2])peptides and hints that the 90° arrangement of the the two aromatic rings found in the cis-Tyr-L-Tic moiety, typical of N-methyl naltrindole and other δ-selective opiate antagonists, is responsible for the antagonist activity of all these peptides. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENKEPHALINS
KW  - PEPTIDES
KW  - TETRAHYDROISOQUINOLINES
KW  - CARBOXYLIC acids
KW  - OPIOIDS
KW  - AMINO acid sequence
N1  - Accession Number: 12133047; Tancredi, Teodorico 1 Salvadori, Severo 2 Amodeo, Pietro 3 Picone, Delia 3 Lazarus, Lawrence H. 4 Bryant, Sharon D. 4 Guerrini, Reme 2 Marzola, Giuliano 5 Temussi, Piero A. 3; Affiliation:  1: ICMIB del CNR, Napoli, Italy.  2: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.  3: Dipartimento di Chimica, Universitä di Napoli Federico  II, Napoli, ltaly.  4: Peptide Neurochemistry, LMNI, National Institute of Environmental Health Sciences, North Carolina USA.  5: Istituto di Farmacologia, Università di Ferrara, Italy.; Source Info: 8/15/94, Vol. 224 Issue 1, p241; Subject Term: ENKEPHALINS; Subject Term: PEPTIDES; Subject Term: TETRAHYDROISOQUINOLINES; Subject Term: CARBOXYLIC acids; Subject Term: OPIOIDS; Subject Term: AMINO acid sequence; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Sivakumar, K.
AU  - Dalakas, M. C.
T1  - Autoimmune syndrome induced by omeprazole.
JO  - Lancet
JF  - Lancet
Y1  - 1994/08/27/
VL  - 344
IS  - 8922
M3  - Letter
SP  - 619
EP  - 620
PB  - Lancet
SN  - 00995355
AB  - Presents a letter to the editor which reports on autoimmune syndrome induced by omeprazole.
KW  - LETTERS to the editor
KW  - OMEPRAZOLE
N1  - Accession Number: 22050303; Sivakumar, K. 1 Dalakas, M. C. 1; Affiliation:  1: Neuromuscular Diseases Section, National Institutes for Neurological Disorders and Stroke, National Institutes Of Health, Bethesda, MD, USA; Source Info: 8/27/1994, Vol. 344 Issue 8922, p619; Subject Term: LETTERS to the editor; Subject Term: OMEPRAZOLE; Number of Pages: 2p; Document Type: Letter; Full Text Word Count: 675
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gibson, Don C.
T1  - COMMUNICATION AND COLLABORATION IN PRIMATOLOGY.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1994/09//
VL  - 34
IS  - 1
M3  - Article
SP  - 97
EP  - 100
SN  - 02752565
AB  - Points out that the seven regional primate centers in the U.S. are a unique national network of nonhuman primate research and resource laboratories established in the 1960s to provide a major scientific resource of regional and national importance to the advancement of biomedical and behavioral research.  National Center for Research Resources; National Institutes of Health; Specific objectives of the seven centers; Major areas of research emphasis.
KW  - RESEARCH institutes
KW  - PRIMATES
KW  - MEDICAL sciences
KW  - ANIMAL models in research
KW  - UNITED States
KW  - NATIONAL Center for Research Resources (U.S.)
KW  - NATIONAL Institutes of Health (U.S.)
N1  - Accession Number: 12319446; Gibson, Don C. 1; Affiliation:  1: Regional Primate Research Centers Program, Comparative Medicine Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland; Source Info: 1994, Vol. 34 Issue 1, p97; Subject Term: RESEARCH institutes; Subject Term: PRIMATES; Subject Term: MEDICAL sciences; Subject Term: ANIMAL models in research; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Research Resources (U.S.) Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dicker, Marvin
AU  - Leighton, Eldin A.
T1  - Trends in the US Prevalence of Drug-Using Parturient Women and Drug-Affected Newborns, 1979 through 1990.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/09//
VL  - 84
IS  - 9
M3  - Article
SP  - 1433
EP  - 1438
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. There has been a lack of reliable national data on the number of pregnant women using drugs and the number of newborns affected by such use. The major reasons for this lack have been inadequate sampling and data collection procedures and the lack of a risk assessment perspective in analysis. This paper corrects for these inadequacies. Methods. Data from 1979 through 1990 from the National Hospital Discharge Survey, an annual survey by the National Center for Health Statistics, were analyzed. Results. Between 1979 and 1990 there was a 576% increase in the rate of discharges of drug-using parturient women in the United States and a 456% increase in the rate of discharges of drug-affected newborns. After adjustment for underreporting, a "best estimate" of the number of discharges from 1988 through 1990 was about 88 000 per year for drug-using parturient women and about 48 000 per year for drug-affected newborns. Conclusions. Although the data support the occurrence of a national epidemic of drug use among pregnant women during the 1980s, the size and severity of this epidemic have been overstated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANT women -- Substance use
KW  - CHILDREN of drug abusers
KW  - DRUG abusers
KW  - NEWBORN infants
KW  - HEALTH
KW  - HEALTH surveys -- United States
KW  - UNITED States
N1  - Accession Number: 9410250727; Dicker, Marvin 1,2 Leighton, Eldin A. 1; Affiliation:  1: Washington Consulting Group, Washington, DC  2: National Institute on Drug Abuse, Rockville, Md.; Source Info: Sep94, Vol. 84 Issue 9, p1433; Subject Term: PREGNANT women -- Substance use; Subject Term: CHILDREN of drug abusers; Subject Term: DRUG abusers; Subject Term: NEWBORN infants; Subject Term: HEALTH; Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wilcox, Allen J.
AU  - Skjærven, Rolv
AU  - Irgens, Lorentz M.
T1  - Harsh Social Conditions and Perinatal Survival: An Age-Period-Cohort Analysis of the World War II Occupation of Norway.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/09//
VL  - 84
IS  - 9
M3  - Article
SP  - 1463
EP  - 1467
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The hypothesis was tested that unfavorable social conditions are associated with poor perinatal survival through direct effects on pregnancy or, more indirectly, through effects on mothers born under such conditions. The occupation of Norway by Nazi Germany was used as a period of social hardship. Methods. Data from Norwegian vital statistics and the Medical Birth Registry were used to describe perinatal mortality during World War II and also a generation later, among babies born to mothers who had themselves been born during the war. Logistic regression was used to identity a possible cohort effect among mothers born in 1940 through 1944 compared with mothers born before or after than period. Results. Harsh conditions in Norway during the occupation increased childhood mortality. However, perinatal mortality declined during that period. Likewise, no adverse effect was seen on the survival of babies born to mothers who had themselves been born during the war (odds ratio = 1.00; 95% confidence interval = 0.96, 1.04). Conclusions. We find no evidence that wartime conditions in Norway impaired perinatal survival, either directly or through an effect on women born during the war. These data underscore how little is known about the ways that social conditions influence perinatal mortality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL history
KW  - PREGNANT women
KW  - PERINATAL death
KW  - WOMEN & war
KW  - WORLD War, 1939-1945
KW  - NORWAY
N1  - Accession Number: 9410250732; Wilcox, Allen J. 1 Skjærven, Rolv 2 Irgens, Lorentz M. 3; Affiliation:  1: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.  2: Section for Medical Informatics and Statistics and the Medical Birth Registry, University of Bergen,  Bergen, Norway  3: Medical Birth Registry and the Division of Preventive Medicine, Department of Public Health and Primary Health Care, University of Bergen; Source Info: Sep94, Vol. 84 Issue 9, p1463; Subject Term: SOCIAL history; Subject Term: PREGNANT women; Subject Term: PERINATAL death; Subject Term: WOMEN & war; Subject Term: WORLD War, 1939-1945; Subject Term: NORWAY; Number of Pages: 5p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pommerenke, Forrest A.
AU  - Miller, Robert W.
AU  - Srivastava, Sudhir
AU  - Ackermann, Susan P.
T1  - Targeting Cancer Control: The State Cancer Control Map and Data Program.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/09//
VL  - 84
IS  - 9
M3  - Article
SP  - 1479
EP  - 1482
PB  - American Public Health Association
SN  - 00900036
AB  - The State Cancer Control Map and Data Program (National Technical Information Service, Springfield, Va) allows state and county mortality maps and data tables to be tailored according to the user's choice of cancer site, age, gender, race, county, and time period between 1953 and 1987. Counties and subpopulations within these maps and data tables that are identified as having exceptionally high rates of specific cancers can then be targeted for early detection or primary prevention. These maps and data table provide a means for focusing state, local, and individual efforts to reduce cancer mortality in appropriate populations in areas with high mortality rates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER prevention
KW  - MAPS
KW  - CHARTS, diagrams, etc.
KW  - CANCER -- Mortality
KW  - MORTALITY
KW  - UNITED States
N1  - Accession Number: 9410250735; Pommerenke, Forrest A. 1 Miller, Robert W. 2 Srivastava, Sudhir 3 Ackermann, Susan P. 4; Affiliation:  1: Department of Preventive Medicine, Medical College of Wisconsin, Milwaukee  2: Early Detection Branch, National Cancer Institute, Centers for Disease Control and Prevention, Atlanta, Ga.  3: Epidemiology Branch, National Cancer Institute, Centers for Disease Control and Prevention, Atlanta, Ga.  4: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Ga.; Source Info: Sep94, Vol. 84 Issue 9, p1479; Subject Term: CANCER prevention; Subject Term: MAPS; Subject Term: CHARTS, diagrams, etc.; Subject Term: CANCER -- Mortality; Subject Term: MORTALITY; Subject Term: UNITED States; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; Number of Pages: 4p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105626015
T1  - The differing presentation of insulin-dependent diabetes mellitus in infants and children.
AU  - Yanovski JA
AU  - Sobel DO
AU  - Abbassi V
Y1  - 1994/09//
N1  - Accession Number: 105626015. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0372606. 
KW  - Diabetes Mellitus, Type 1 -- Diagnosis
KW  - Adolescence
KW  - Age Factors
KW  - Bicarbonates -- Blood
KW  - Blood Gas Analysis
KW  - Blood Glucose -- Analysis
KW  - Blood Urea Nitrogen
KW  - Child
KW  - Child, Preschool
KW  - Creatinine -- Analysis
KW  - Diabetes Mellitus, Type 1 -- Blood
KW  - Diabetes Mellitus, Type 1 -- Complications
KW  - Diabetes Mellitus, Type 1 -- Epidemiology
KW  - Female
KW  - Hemoglobins -- Analysis
KW  - Hydrogen-Ion Concentration
KW  - Male
KW  - Prospective Studies
KW  - Severity of Illness Indices
KW  - Human
SP  - 556
EP  - 560
JO  - Clinical Pediatrics
JF  - Clinical Pediatrics
JA  - CLIN PEDIATR
VL  - 33
IS  - 9
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0009-9228
AD  - Section on Developmental Endocrinology, DEB, NICHD National Institutes of Health, Bethesda, Maryland 20892.
U2  - PMID: 8001325.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107410348
T1  - How to help your patients stop using tobacco.
AU  - Meckleburg RE
Y1  - 1994///1994 Fall
N1  - Accession Number: 107410348. Language: English. Entry Date: 19950601. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials. Journal Subset: Allied Health; USA. NLM UID: 9816286. 
KW  - Smoking Cessation
KW  - Dental Health Education
SP  - 9
EP  - 9
JO  - Dental Hygienist News
JF  - Dental Hygienist News
JA  - DENT HYG NEWS
VL  - 7
IS  - 4
CY  - Bloomfield Hills, Michigan
PB  - Lally, McFarland, & Pantello
SN  - 1082-9016
AD  - National Cancer Institute, US Department of Health and Human Services
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Jindo, Toshimasa
AU  - Tsuboi, Ryoji
AU  - Imai, Ryusuke
AU  - Takamori, Kenji
AU  - Rubin, Jeffrey S.
AU  - Ogawa, Hideoki
T1  - Hepatocyte Growth Factor/Scatter Factor Stimulates Hair Growth of Mouse Vibrissae in Organ Culture.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/09//
VL  - 103
IS  - 3
M3  - Article
SP  - 306
EP  - 309
SN  - 0022202X
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional polypeptide that acts as a mitogen, motogen, or morphogen, depending on the biologic context. In this study, we examined the effect of HGF/ SF on hair growth using a serum-free organ culture system. Vibrissal hair follicles isolated from newborn mice were cultured at 31°C in 95% O2/5% CO2 for 72 h in the presence of various cytokines or growth factors, and elongation of hair shaft, DNA, and protein synthesis in hair follicles were measured. Among the agents tested, only HGF/SF significantly increased hair follicle length (p < 0.00 1), ³H-thymidine (p < 0.001), and 35S-cysteine (p < 0.05) incorporation. The effect of HGF/SF was dose dependent, with maximal stimulation obtained at 10 ng/ml. The increase in hair follicle length and thymidine incorporation were specifically inhibited by a neutralizing antibody against HGF/SF. These results indicate that HGF/SF can promote hair growth and may have clinical utility in this regard. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOKINES
KW  - FIBROBLAST growth factors
KW  - HAIR growth stimulants
KW  - WHISKERS
KW  - MICE
KW  - ORGAN culture
KW  - GROWTH factors
KW  - fibroblast growth factor
KW  - IL-1α.
KW  - TNFα
N1  - Accession Number: 12394731; Jindo, Toshimasa 1 Tsuboi, Ryoji 1 Imai, Ryusuke 1 Takamori, Kenji 1 Rubin, Jeffrey S. 2 Ogawa, Hideoki 1; Affiliation:  1: Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.  2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Sep94, Vol. 103 Issue 3, p306; Subject Term: CYTOKINES; Subject Term: FIBROBLAST growth factors; Subject Term: HAIR growth stimulants; Subject Term: WHISKERS; Subject Term: MICE; Subject Term: ORGAN culture; Subject Term: GROWTH factors; Author-Supplied Keyword: fibroblast growth factor; Author-Supplied Keyword: IL-1α.; Author-Supplied Keyword: TNFα; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12394731
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Liu, Lei
AU  - Shack, Sonsoles
AU  - Stetler-Stevenson, William G.
AU  - Hudgins, W. Robert
AU  - Samid, Dvorit
T1  - Differentiation of Cultured Human Melanoma Cells Induced by the Aromatic Fatty Acids Phenylacetate and Phenylbutyrate.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/09//
VL  - 103
IS  - 3
M3  - Article
SP  - 335
EP  - 340
SN  - 0022202X
AB  - The increasing incidence of melanoma and the poor responsiveness of disseminated disease to conventional treatments call for the development of new therapeutic approaches. Phenylacetate, a nontoxic differentiation inducer, can suppress the growth of other neuro- ectodermal tumors, i.e., gliomas, in laboratory models and in humans. This finding led us to explore the efficacy of phenylacetate and related aromatic fatty acids in melanoma. Phenylacetate and phenylbutyrate were found to a) induce selective cytostasis and maturation of cultured human melanoma cells, b) modulate the expression of genes implicated in tumor metastasis (type IV collagenase and tissue inhibitor of metalloproteinases-2) and immunogenicity (HLA class I); and c) enhance the efficacy of other agents of clinical interest, including retinoids, interferon-alpha, suramin, and 5-aza-2'-deoxycytidine. Reflecting on the phenotypic heterogeneity of melanoma, the degree of biologic alterations induced by phenylacetate, phenylbutyrate varied significantly among the tumor cell lines tested. Although losing invasive capacity and tumorigenicity in athymic mice, poorly differentiated cells exhibited only a marginal change in morphology, remained amelanotic, and resumed growth after treatment was discontinued. By contrast, treatment of melanoma cells that were in a more advanced stage of maturation resulted in profound alterations in cell growth, morphology, and pigmentation consistent with terminal differentiation. The <em>in vitro</em> antitumor activity was observed with nontoxic, pharmacologic concentrations of phenylacetate and phenylbutyrate, suggesting potential clinical use of these drugs in the treatment of melanomas. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOMA
KW  - METASTASIS
KW  - PHENYLACETATES
KW  - GLIOMAS
KW  - FATTY acids
KW  - ANTINEOPLASTIC agents
KW  - cytostasis
KW  - invasion
KW  - melanogenesis
KW  - proteolysis.
KW  - tumorigenicity
N1  - Accession Number: 12394874; Liu, Lei 1 Shack, Sonsoles 1 Stetler-Stevenson, William G. 2 Hudgins, W. Robert 1 Samid, Dvorit 1; Affiliation:  1: Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Sep94, Vol. 103 Issue 3, p335; Subject Term: MELANOMA; Subject Term: METASTASIS; Subject Term: PHENYLACETATES; Subject Term: GLIOMAS; Subject Term: FATTY acids; Subject Term: ANTINEOPLASTIC agents; Author-Supplied Keyword: cytostasis; Author-Supplied Keyword: invasion; Author-Supplied Keyword: melanogenesis; Author-Supplied Keyword: proteolysis.; Author-Supplied Keyword: tumorigenicity; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12394874
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107403830
T1  - Misdiagnosed HIV infection in pregnant women: implications for clinical care.
AU  - Sheon AR
AU  - Fox HE
AU  - Alexander G
AU  - Buck A
AU  - Higgins A
AU  - McDermott SM
AU  - Moroso G
AU  - Moye J
AU  - Pacheco-Acosta E
Y1  - 1994/09//Sep/Oct94
N1  - Accession Number: 107403830. Language: English. Entry Date: 19950401. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Instrumentation: Women and Infants Transmission Study (WITS). Grant Information: Supported by contracts with the National Institutes of Health, N01-AI-82505, N01-AI-82506, N01AI-82507, N01-AI-85005, N01-AI-05072, and N01-HD- 8-2913. NLM UID: 9716844. 
KW  - AIDS Serodiagnosis -- Adverse Effects
KW  - Women
KW  - HIV Infections -- Diagnosis
KW  - HIV Seropositivity -- Psychosocial Factors
KW  - Funding Source
KW  - United States
KW  - False Positive Results
KW  - AIDS Serodiagnosis -- Standards
KW  - Research Instruments
KW  - HIV Infections -- Transmission -- In Pregnancy
KW  - Secondary Analysis
KW  - Infant, Newborn
KW  - Pregnancy
KW  - Female
KW  - Fetus
KW  - Human
SP  - 694
EP  - 699
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 109
IS  - 5
PB  - Sage Publications Inc.
AB  - Out of nearly 900 women in a research study of human immunodeficiency virus infection in pregnancy, 8 were subsequently found not to be infected. Misdiagnoses could have resulted from (a) laboratory errors or specimen mixups; (b) failure to follow the testing algorithm recommended by the Centers for Disease Control and Prevention to confirm results; (c) women perceiving they were infected by high-risk behavior in the absence of testing, despite the receipt of negative test results, or based on screening results only; or (d) factitious disorder, HIV Munchausen syndrome, or malingering. Because of the potentially devastating impact of an HIV diagnosis and the toxicity of HIV therapies, health care providers should obtain independent confirmation of the diagnosis before initiating treatment or followup for HIV based on patient report or provider referral. Quality test interpretation and counseling must be ensured. Therapeutic interventions may be indicated for persons intentionally and falsely presenting themselves as HlV-infected.
SN  - 0033-3549
AD  - Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Blvd, Rockville, MD 20892
U2  - PMID: 7938392.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
T1  - A Working Conceptualization of Social Structure: Mertonian Roots and Psychological and Sociocultural Relationships.
JO  - Social Psychology Quarterly
JF  - Social Psychology Quarterly
Y1  - 1994/09//
VL  - 57
IS  - 3
M3  - Article
SP  - 262
EP  - 273
SN  - 01902725
AB  - Using a small set of interlocking definitions, this paper presents a generally applicable conceptualization of social structure developed from recollections of Merton's late-1950s formulation. A brief review of the literature supports the view that the proposed conceptualization provides sociological researchers with a relatively simple and logically consistent overall framework, generally continuous with past theorizing, in which to place their own findings. The paper pays particular attention to how social structures are related causally and epistemologically to more micro-level psychological and more macrolevel sociocultural phenomena. Theoretical considerations and empirical evidence suggest a decrease in the likelihood and speed of change as we move from psychological- to social structural- to sociocultural-level phenomena. Although they require proof in each instance, these postulated differences in the relative speed with which psychological-, social structural-, and sociocultural-level phenomena tend to affect each other provide a new and potentially useful tool for unraveling the knotted causal connections among these different-level phenomena. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Psychology Quarterly is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL structure
KW  - SOCIOLOGY
KW  - CULTURE
KW  - SOCIAL change
KW  - SOCIAL psychology
N1  - Accession Number: 9411046545; Schooler, Carmi 1; Affiliation:  1: National Institute of Mental Health; Source Info: Sep94, Vol. 57 Issue 3, p262; Subject Term: SOCIAL structure; Subject Term: SOCIOLOGY; Subject Term: CULTURE; Subject Term: SOCIAL change; Subject Term: SOCIAL psychology; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2008-13518-008
AN  - 2008-13518-008
AU  - Eacott, M. J.
AU  - Gaffan, D.
AU  - Murray, E. A.
T1  - Preserved recognition memory for small sets, and impaired stimulus identification for large sets, following rhinal cortex ablations in monkeys.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1994/09//
VL  - 6
IS  - 9
SP  - 1466
EP  - 1478
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Gaffan, D., Department of Experimental Psychology, Oxford University, South Parks Road, Oxford, United Kingdom, OX1 3UD
N1  - Accession Number: 2008-13518-008. PMID: 8000570 Partial author list: First Author & Affiliation: Eacott, M. J.; Department of Experimental Psychology, Oxford University, Oxford, United Kingdom. Other Publishers: Blackwell Publishing. Release Date: 20110103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Cortex; Matching to Sample; Visual Memory; Brain Lesions (Experimental). Minor Descriptor: Monkeys. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Sep, 1994. Publication History: Accepted Date: Apr 18, 1994; Revised Date: Apr 13, 1994; First Submitted Date: Dec 27, 1993. Copyright Statement: European Neuroscience Association
AB  - Seven cynomolgus monkeys (Macaca fascicularis) performed a series of tasks designed to assess their visual memory and their ability to identify visual stimuli. Preoperatively they were trained and tested in delayed and simultaneous matching-to-sample, both with a large stimulus set and with a small stimulus set; there were ∼500 million possible stimuli in the large set, which effectively means that stimuli were trial-unique with this set, while in the small set there were only four stimuli, which appeared repeatedly in every session of training with the small set. Three of the monkeys then had the cortex within and adjacent to the rhinal sulcus removed bilaterally, while the other four served as an unoperated control group. Postoperatively, the animals with ablation of the rhinal cortex showed severe impairment in delayed matching-to-sample with the large set. With the large set they were also impaired, however, in matching-to-sample with no delay between sample and test (0 s delay) and in simultaneous matching-to-sample, in which the sample and the two choice patterns were simultaneously present for inspection. The impairment in simultaneous matching-to-sample was particularly clear when the task was made more difficult by reducing the physical discriminability of the trial-unique stimuli. With the small set of four stimuli, the animals with rhinal cortex ablation were not significantly impaired in overall performance level in delayed matching-to-sample, though their level was on average below that of the normal control animals. The stimulus set was then further restricted, so that there were now only two stimuli used throughout; in this condition, the animals with rhinal cortex ablation performed delayed matching-to-sample without any suggestion of impairment, showing indistinguishable performance levels from those of the control animals over a range of forgetting intervals. Subsequently, the animals were trained in trial-unique non-matching-to-sample with 0 s delay, which required reversal of the matching-to-sample rule they had previously learned; animals with rhinal cortex ablation showed a clear impairment in this rule-reversal learning. The final experimental task was a concurrent discrimination learning task in which 20 pairs of stimuli were presented once per session; the animals with rhinal cortex ablation learned more slowly than the control animals on average, but the difference between the groups did not attain statistical significance. Overall, this pattern of deficits and of preserved abilities is clearly inconsistent with the idea that rhinal cortex ablation produces an impairment in all forms of visual recognition memory, and only in visual recognition memory. Instead, the present results indicate a general impairment in the capacity for knowledge about visual stimuli. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - recognition memory
KW  - rhinal cortex
KW  - monkeys
KW  - visual memory
KW  - ablation
KW  - 1994
KW  - Cerebral Cortex
KW  - Matching to Sample
KW  - Visual Memory
KW  - Brain Lesions (Experimental)
KW  - Monkeys
KW  - 1994
U1  - Sponsor: Medical Research Council, United Kingdom. Recipients: No recipient indicated
U1  - Sponsor: North Atlantic Treaty Organization. Grant: 0184/87. Recipients: No recipient indicated
DO  - 10.1111/j.1460-9568.1994.tb01008.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36262-035
AN  - 2015-36262-035
AU  - Caudle, Robert M.
AU  - Chavkin, Charles
AU  - Dubner, Ronald
T1  - κ₂ opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/09//
VL  - 14
IS  - 9
SP  - 5580
EP  - 5589
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Caudle, Robert M., NAB, NIDR, NIH, Building 49/Roam A-11, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36262-035. PMID: 7916046 Partial author list: First Author & Affiliation: Caudle, Robert M.; Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, US. Release Date: 20160808. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Chavkin, Charles. Major Descriptor: Guinea Pigs; Hippocampus; N-Methyl-D-Aspartate; Neural Receptors. Minor Descriptor: Opiates. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 1994. Publication History: Accepted Date: Mar 24, 1994; Revised Date: Mar 17, 1994; First Submitted Date: Sep 13, 1993. Copyright Statement: Society for Neuroscience. 1994. 
AB  - The role of the endogenous opioid peptide dynorphin (1-17) in regulating NMDA receptor-mediated synaptic currents was examined in guinea pig hippocampus. Schaffer collateral/ commissural fiber-evoked NMDA synaptic currents were recorded using whole-cell patch-clamp techniques in CA3 pyramidal cells. Dynorphin was found to have dual effects on NMDA synaptic currents, increasing currents at low concentrations and decreasing currents at high concentrations. Only the inhibitory action of dynorphin was sensitive to naloxone, indicating that this effect was mediated by an opioid receptor. The inhibitory effect was mimicked by bremazocine, but not by U69,593, U50,466, [D-Ala², N-Me-Phe⁴, Gly-ol]-enkephalin, or [D-Pen2,5]-enkephalin. Bremazocine’s effect was blocked by naloxone, but not by nor-binaltorphimine, cyprodime, or naltrindole. These findings suggest that bremazotine’s effect was mediated by the κ₂ subtype of opioid receptor. In addition, 1 μM naloxone and antisera to dynorphin (1-17) were found to increase NMDA-mediated synaptic currents. Nor-binaltorphimine, cyprodime, naltrindole, and antisera to met-enkephalin did not increase the NMDA synaptic current. These findings suggest that endogenous dynorphin was acting at κ₂ receptors to inhibit NMDA receptor-mediated synaptic currents. Overall, these findings indicate that dynorphin is an endogenous agonist for κ₂ receptors in the CA3 region of the guinea pig hippocampus and that these receptors regulate NMDA receptor function. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - opioids
KW  - dynorphin
KW  - kappa receptors
KW  - N-methy/- D-aspartate receptors (NMDA)
KW  - whole cell patch clamp
KW  - hippocampus
KW  - guinea pig
KW  - CA31
KW  - 1994
KW  - Guinea Pigs
KW  - Hippocampus
KW  - N-Methyl-D-Aspartate
KW  - Neural Receptors
KW  - Opiates
KW  - 1994
U1  - Sponsor: U.S. Public Health Service, US. Grant: DA04123. Recipients: Chavkin, Charles
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Klimpel, Kurt R.
AU  - Arora, Naveen
AU  - Leppla, Stephen H.
T1  - Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1994/09/15/
VL  - 13
IS  - 6
M3  - Article
SP  - 1093
EP  - 1100
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Comparison of the anthrax toxin lethal factor (LF) amino acid sequence with sequences in the Swiss protein database revealed short regions of similarity with the consensus zinc-binding site, HEXXH, that is characteristic of metalioproteases. Several protease inhibitors, including bestatin and captopril, prevented intoxication of macrophages by lethal toxin. LF was fully inactivated by site-directed mutagenesis that substituted Ala for either of the residues (H-686 and H-690) implicated in zinc binding. Similarly, LF was inactivated by substitution of Cys for E-687, which is thought to be an essential part of the catalytic site. In contrast, replacement of E-720 and E-721 with Ala had no effect on LF activity. LF bound 65Zn both in solution and on protein blots. The 65Zn binding was reduced for several of the LF mutants. These data suggest that anthrax toxin LF is a zinc metallopeptidase, the catalytic function of which is responsible for the lethal activity observed in cultured cells and in animals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxins
KW  - Anthrax
KW  - Amino acids
KW  - Proteins
KW  - Protease inhibitors
KW  - Bestatin
KW  - Captopril
KW  - Mutagenesis
KW  - Macrophages
N1  - Accession Number: 17471548; Klimpel, Kurt R. 1; Arora, Naveen 2; Leppla, Stephen H. 2; Affiliations: 1: Laboratory of Microbial Ecology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Laboratory of Microbial Ecology, National Institute of Dental Research. National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Sep1994, Vol. 13 Issue 6, p1093; Thesaurus Term: Toxins; Subject Term: Anthrax; Subject Term: Amino acids; Subject Term: Proteins; Subject Term: Protease inhibitors; Subject Term: Bestatin; Subject Term: Captopril; Subject Term: Mutagenesis; Subject Term: Macrophages; Number of Pages: 8p; Illustrations: 2 Diagrams, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107418413
T1  - The blessing -- and curse -- of genetic testing.
AU  - Biesecker BB
AU  - Billings PR
AU  - Caplan AL
AU  - Caskey CT
Y1  - 1994/09/15/
N1  - Accession Number: 107418413. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0246161. 
KW  - Genetic Screening
KW  - Discrimination
KW  - Privacy and Confidentiality
KW  - Insurance, Health
KW  - Ethics, Medical
KW  - Outpatients
SP  - 20
EP  - 33
JO  - Patient Care
JF  - Patient Care
JA  - PATIENT CARE
VL  - 28
IS  - 14
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Genes are being cloned and DNA tests developed at a dazzling pace. How will this explosion of information affect your relationship with patients? And how will you deal with the ethical issues it raises?
SN  - 0031-305X
AD  - National Center for Human Genome Research, National Institutes of Health, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850825
T1  - Age at diagnosis and transmission of invasive melanoma in 23 families with cutaneous malignant melanoma/dysplastic nevi.
AU  - Goldstein AM
AU  - Fraser MC
AU  - Clark WH Jr
AU  - Tucker MA
Y1  - 1994/09/21/
N1  - Accession Number: 105850825. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Melanoma -- Diagnosis
KW  - Nevus -- Diagnosis
KW  - Skin Neoplasms -- Diagnosis
KW  - Adolescence
KW  - Adult
KW  - Age of Onset
KW  - Aged
KW  - Child
KW  - Female
KW  - Life Table Method
KW  - Male
KW  - Melanoma -- Pathology
KW  - Melanoma
KW  - Middle Age
KW  - Neoplasm Invasiveness
KW  - Nevus -- Pathology
KW  - Nevus
KW  - Probability
KW  - Sex Factors
KW  - Skin Neoplasms -- Pathology
KW  - Skin Neoplasms
KW  - Human
SP  - 1385
EP  - 1390
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 86
IS  - 18
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 8072031.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850822
T1  - Premorbid diet and the prognosis of women with breast cancer.
AU  - Jain M
AU  - Miller AB
AU  - To T
Y1  - 1994/09/21/
N1  - Accession Number: 105850822. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Mortality
KW  - Diet
KW  - Adult
KW  - Ascorbic Acid -- Administration and Dosage
KW  - Beta Carotene
KW  - Breast Neoplasms -- Etiology
KW  - Breast Neoplasms -- Pathology
KW  - Carotenoids -- Administration and Dosage
KW  - Cox Proportional Hazards Model
KW  - Dose-Response Relationship, Drug
KW  - Female
KW  - Life Table Method
KW  - Middle Age
KW  - Prognosis
KW  - Human
SP  - 1390
EP  - 1397
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 86
IS  - 18
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Cancer Institute of Canada, Department of Preventive Medicine and Biostatistics, University of Toronto, Ontario.
U2  - PMID: 8072032.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Boinski, Sue
AU  - Mitchell, Carol L.
T1  - Male Residence and Association Patterns in Costa Rican Squirrel Monkeys (Saimiri oerstedi).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1994/10//
VL  - 34
IS  - 2
M3  - Article
SP  - 157
EP  - 169
SN  - 02752565
AB  - A model is developed to interpret the evolution of the unusual pattern of male residence and social structure in the Costa Rican squirrel monkey (Saimiri oerstedi). Observation of a wild population document that males 1) maintain close spatial and social associations with other males, especially other males in their birth cohort, but not females and infants; 2) exhibit negligible within-troop male-male aggression, high levels of anti-predator vigilance, and frequent predator deterrence; 3) cooperate in aggressive olfactory investigation of females; and 4) maintain residence in their natal troop with their male birth cohort, eventually succeeding to reproductive positions in their natal troop. Less commonly, male age-cohorts leave the troop well past reproductive maturity and usurp the reproductive male cohort in another troop. We suggest that this divergence from the social structure typical of male squirrel monkeys in Peru (males transient between troops, weak male-male bonds, high within-troop male aggression, little investment in anti-predator behavior) arose because female S. oerstedi in Costa Rica are not philopatric. In Costa Rica, long term reproductive cooperation is likely advantageous to males, because of the frequent movement of female S. oerstedi between troops; the potential costs of inbreeding are reduced. Male S. oerstedi of all ages residing in the same troop but especially those of the same age cohort, are predicted to have a much higher degree of genetic relatedness than adult females. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUIRREL monkeys
KW  - MONKEYS
KW  - SOCIAL behavior in animals
KW  - ANIMAL societies
KW  - ANIMAL behavior
KW  - ANIMAL psychology
N1  - Accession Number: 12318540; Boinski, Sue 1,2 Mitchell, Carol L. 3; Affiliation:  1: Department of Anthropology, University of Florida, Gainesville  2: Laboratory of Comparative Ethology, National Institutes of Health-Animal Center, Poolesville, Maryland  3: Amazonian Biodiversity Project, Cusco, Peru; Source Info: 1994, Vol. 34 Issue 2, p157; Subject Term: SQUIRREL monkeys; Subject Term: MONKEYS; Subject Term: SOCIAL behavior in animals; Subject Term: ANIMAL societies; Subject Term: ANIMAL behavior; Subject Term: ANIMAL psychology; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Riley, Gerald F.
AU  - Potosky, Arnold L.
AU  - Lubitz, James D.
AU  - Brown, Martin L.
T1  - Stage of Cancer Diagnosis for Medicare HMO and Fee-for-Service Enrollees.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/10//
VL  - 84
IS  - 10
M3  - Article
SP  - 1598
EP  - 1598
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Health maintenance organizations (HMOs) with Medicare contracts often provide cancer screening and preventive services not conferred under fee-for-service. This study compared cancer patients in HMOs and fee-for-service on stage at diagnosis. Methods. The study examined stage at diagnosis for aged Medicare enrollees in HMOs and fee-for-service, using, information from the surveillance, Epidemiology, and results program, linked with Medicare enrollment files. Twelve cancer sites were investigated, and demographics, area of residence, year of diagnosis (1985 to 1989), and education at the census tract level were controlled. Results. HMO enrollees were diagnosed at earlier stages for cancers of the female breast, cervix, colon, and melanomas and at later stages for stomach cancer. There were no differences for cancer. There were nod differences for cancers of the prostate, rectum, buccal cavity and pharynx, bladder, uterus, kidney, and ovary, HMO effects were strongest in areas with large, mature HMOs. Conclusions. Compared with fee-for-service enrollees, HMO enrollees were diagnosed at earlier stages for cancer sites for which effective screening services are available. The earlier detection of certain cancers among HMO enrollees may result form coverage of screening services and, perhaps, promotion by HMOs of such services. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEALTH maintenance organizations
KW  - MEDICARE
KW  - CANCER prevention
KW  - MEDICAL screening
KW  - CANCER patients
N1  - Accession Number: 9411030290; Riley, Gerald F. 1 Potosky, Arnold L. 2 Lubitz, James D. 1 Brown, Martin L. 2; Affiliation:  1: Health Care Financing Administration, Baltimore, Md.  2: National Cancer Institute, Bethesda, Md.; Source Info: Oct94, Vol. 84 Issue 10, p1598; Subject Term: HEALTH maintenance organizations; Subject Term: MEDICARE; Subject Term: CANCER prevention; Subject Term: MEDICAL screening; Subject Term: CANCER patients; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bernstein, K. A.
AU  - Kahl, L. E.
AU  - Balow, J. E.
AU  - Lefkowith, J. B.
T1  - Serologic markers of lupus nephritis in patients: use of a tissue-based ELISA and evidence for immunopathogenic heterogeneity.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1994/10//
VL  - 98
IS  - 1
M3  - Article
SP  - 60
EP  - 65
PB  - Wiley-Blackwell
SN  - 00099104
AB  - In order to assess the ability of various serologic assays to correlate with lupus nephritis, we analysed sera obtained from 60 patients with systemic lupus erythematosus (SLE). Patients were categorized as having active nephritis (group 1), active lupus without nephritis (group 2), inactive lupus with prior nephritis (group 3), or inactive lupus without prior nephritis (group 4). Three parameters were assessed including anti-dsDNA antibodies (Farr assay), immune complexes (C1q binding), and anti-C1q antibodies (salt-stable C1q binding). Additionally, glomerular binding activity (GBA) was measured using a new solid-phase immunoassay that detects immune elements by their ability to bind glomerular tissue. We found that patients with nephritis (group 1) exhibited higher mean values for each assay than patients in each of the other three groups (P = 0.001, 0.009, 0.14, and 0.23 in the GBA, C1q, anti-dsDNA, and anti-C1q assays, respectively). The only assay which distinguished patients with nephritis (group 1) from patients having active disease without nephritis (group 2) was the GBA (mean 0.48 ± 0.09 versus 0.15 ± 0.04, P < 0.05). In terms of utility, all tests were specific for diagnosing nephritis among patients with lupus; however, only the GBA was reasonably sensitive. The information provided by the anti-dsDNA and C1q assays were not correlated with one another, nor additive to the GBA. Patients with false negative GBA tended to have received more intensive immunosuppression. The qualitative characteristics of GBA varied among patients with nephritis. These data suggest the pathogenesis of lupus nephritis is complex, and may be mediated by an array of immune elements. Moreover, the data indicate the potential utility for a broad tissue-based approach to detection of pathogenic immune elements over other, specific immunologic markers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ENZYME-linked immunosorbent assay
KW  - LUPUS nephritis
KW  - SYSTEMIC lupus erythematosus
KW  - IMMUNOGLOBULINS
KW  - DNA
KW  - IMMUNOSUPPRESSION
KW  - anti-DNA
KW  - glomerulonephritis
KW  - lupus
N1  - Accession Number: 15984939; Bernstein, K. A. 1 Kahl, L. E. 1 Balow, J. E. 2 Lefkowith, J. B. 1,3; Affiliation:  1: Department of Medicine, Washington University School of Medicine, St Louis, MO.  2: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.  3: Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO.; Source Info: Oct1994, Vol. 98 Issue 1, p60; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: LUPUS nephritis; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: IMMUNOGLOBULINS; Subject Term: DNA; Subject Term: IMMUNOSUPPRESSION; Author-Supplied Keyword: anti-DNA; Author-Supplied Keyword: glomerulonephritis; Author-Supplied Keyword: lupus; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1365-2249.ep15984939
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hubbs-Tait, Laura
AU  - Osofsky, Joy D.
AU  - Della M. Hann
AU  - Anne McDonald Culp
T1  - PREDICTING BEHAVIOR PROBLEMS AND SOCIAL COMPETENCE IN CHILDREN OF ADOLESCENT MOTHERS.
JO  - Family Relations
JF  - Family Relations
Y1  - 1994/10//
VL  - 43
IS  - 4
M3  - Article
SP  - 439
EP  - 446
SN  - 01976664
AB  - The article presents a longitudinal investigation evaluating an additive model of the impact of adolescent mothers' parenting practices on their children regression models. Subjects were 44 children and their adolescent mothers who were part of a larger longitudinal study of adolescent mothers and their children. Socioeconomic status of adolescent mothers is difficult to estimate, the use of education and occupation is not possible because most have not graduated from school and few have full-time occupations. Infant attachment was also assessed. Maternal self-esteem was assessed by the "Index of Self-Esteem." One hierarchical regression analysis was conducted for each of the two child behavior problems outcomes and for each of the two child social competence outcomes. The current study supports the additive model of the impact of adolescent parenting on children's social competence. The results support the additive model of adolescent parenting.
KW  - MOTHERS
KW  - TEENAGERS
KW  - REGRESSION analysis
KW  - SOCIAL status
KW  - EDUCATION
KW  - SELF-esteem
KW  - adolescent mothers
KW  - attachment
KW  - behavior problems
KW  - Child Rearing and Parental Roles
KW  - maternal depression
KW  - social competence.
N1  - Accession Number: 9412161118; Hubbs-Tait, Laura 1 Osofsky, Joy D. 2 Della M. Hann 3 Anne McDonald Culp 4; Affiliation:  1: Associate Professor in the Department of Family Relations and Child Development.  2: Professor of Pediatrics and Psychiatry at the Louisiana State University Medical Center, New Orleans, LA 70112.  3: Program Officer for the interpersonal and Family Processes Program in the Behavioral, Cognitive, and Social Processes Research Branch of the National institute of Mental Health, Rockville, MD 20857.  4: Associate Professor in the Department of Family Relations and Child Development at Oklahoma State University, Stillwater, OK 74078.; Source Info: Oct94, Vol. 43 Issue 4, p439; Subject Term: MOTHERS; Subject Term: TEENAGERS; Subject Term: REGRESSION analysis; Subject Term: SOCIAL status; Subject Term: EDUCATION; Subject Term: SELF-esteem; Author-Supplied Keyword: adolescent mothers; Author-Supplied Keyword: attachment; Author-Supplied Keyword: behavior problems; Author-Supplied Keyword: Child Rearing and Parental Roles; Author-Supplied Keyword: maternal depression; Author-Supplied Keyword: social competence.; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 8395
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hauser, Stuart T.
AU  - Huffman, Lynne C.
T1  - Introduction: Affective Processes in Adolescence.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1994/10//
VL  - 4
IS  - 4
M3  - Article
SP  - 465
EP  - 467
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - This Special Issue represents a major product of a National Institute of Mental Health (NIMH) sponsored workshop, held October 19-20,1992, in Bethesda, Maryland. Consistent with accelerating interest in the understanding of affective processes during the adolescent period, the Behavioral, Cognitive, and Social Processes Research Branch of NIMH generously supported several meetings to plan the workshop, the workshop itself, and the sustained subsequent efforts to transform the 2 days of talks and discussions into a coherent volume that could be distributed to our scientific colleagues. The major goal of the workshop, organized by Stuart Hauser and Lynne Huffman, was to explore multilevel approaches to research on affective processes during the adolescent period, including psychophysiological, behavioral, intrapsychic, interactional, and sociocultural perspectives. Experts and discussants were invited to discuss conceptual advances that might be facilitated by an integration and cross-fertilization of basic and clinical viewpoints. Workshop participants and observers were also encouraged to offer suggestions regarding critical future research questions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Research on Adolescence (Lawrence Erlbaum) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL health -- Congresses
KW  - CONFERENCES & conventions
KW  - BETHESDA (Md.)
KW  - MARYLAND
KW  - UNITED States
N1  - Accession Number: 11325609; Hauser, Stuart T. 1 Huffman, Lynne C. 2; Affiliation:  1: Harvard University  2: National Institute of Mental Health; Source Info: 1994, Vol. 4 Issue 4, p465; Subject Term: MENTAL health -- Congresses; Subject Term: CONFERENCES & conventions; Subject Term: BETHESDA (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Huffman, Lynne C.
AU  - Hauser, Stuart T.
T1  - Afterword: Reflections and Future Directions.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1994/10//
VL  - 4
IS  - 4
M3  - Article
SP  - 657
EP  - 662
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - The preceding articles reflect the continued and evolving interest of basic and clinical research scientists and the National Institute of Mental Health (NIMH) in the study of affective processes during the adolescent period. In this afterword, through drawing together a future research agenda, we integrate the contributions of the articles with the discussions among workshop participants that followed each presentation and continued throughout the 2-day workshop on affective processes in adolescence. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Research on Adolescence (Lawrence Erlbaum) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADOLESCENT psychology
KW  - AFFECT (Psychology)
KW  - MENTAL health
N1  - Accession Number: 11325973; Huffman, Lynne C. 1 Hauser, Stuart T. 2; Affiliation:  1: National Institute of Mental Health  2: Harvard University; Source Info: 1994, Vol. 4 Issue 4, p657; Subject Term: ADOLESCENT psychology; Subject Term: AFFECT (Psychology); Subject Term: MENTAL health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107405125
T1  - A research agenda for women's mental health.
AU  - Leibenluft E
Y1  - 1994/10//1994 Oct
N1  - Accession Number: 107405125. Language: English. Entry Date: 19950401. Revision Date: 20150820. Publication Type: Journal Article; proceedings; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Mental Health
KW  - Women's Health
KW  - Research, Medical
KW  - Mental Disorders
KW  - Substance Abuse
KW  - Menopause
KW  - Affective Disorders
KW  - Research Question
KW  - Sex Factors
KW  - Gender Identity
KW  - Research Priorities
KW  - Female
SP  - 377
EP  - 382
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 3
IS  - 5
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - Since many of the major psychiatric illnesses are more prevalent in women than men, women have generally been adequately represented in studies of patients with mood, anxiety, and eating disorders. However, women with substance abuse disorders have received little research attention, and a number of recent studies show significant gender differences in the presentation and course of alcoholism. In addition, remarkably little research has been done on the psychiatric effects of the menopause in depressed women, despite the fact that the two conditions frequently coexist. The advantages of a biopsychosocial approach to women's mental health research are discussed.
SN  - 1059-7115
AD  - Clinical Psychobiology Branch, National Institute of Mental Health, Bldg 10, Rm 4S239, 10 Center Dr, MSC #1390, Bethesda, Maryland, 20892-1390
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107296474
T1  - Antiretroviral therapy for infection due to human immunodeficiency virus in children.
AU  - Pizzo PA
AU  - Wilfert C
Y1  - 1994/10//1994 Oct
N1  - Accession Number: 107296474. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9107942. 
KW  - HIV Infections -- Drug Therapy -- In Infancy and Childhood
KW  - Antiviral Agents -- Therapeutic Use -- In Infancy and Childhood
KW  - Infant
KW  - Child, Preschool
KW  - Child
SP  - 273
EP  - 295
JO  - Pediatric AIDS & HIV Infection
JF  - Pediatric AIDS & HIV Infection
JA  - PEDIATR AIDS HIV INFECT
VL  - 5
IS  - 5
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1045-5418
AD  - Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 11361369.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-36269-031
AN  - 2015-36269-031
AU  - Petralia, R. S.
AU  - Wang, Y.-X.
AU  - Wenthold, R. J.
T1  - The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/10//
VL  - 14
IS  - 10
SP  - 6102
EP  - 6120
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Petralia, R. S., Laboratory of Neurochemistry, NIDCD, NIH, Building 36, Room 5D-08, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36269-031. PMID: 7931566 Partial author list: First Author & Affiliation: Petralia, R. S.; Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD, US. Release Date: 20160808. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amino Acids; Hippocampus; N-Methyl-D-Aspartate; Immunocytochemistry. Minor Descriptor: Cerebellum; Rats; AMPA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 19. Issue Publication Date: Oct, 1994. Publication History: Accepted Date: Apr 6, 1994; Revised Date: Mar 22, 1994; First Submitted Date: Feb 7, 1994. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Neuronal plasticity associated with learning, memory and development is controlled, in part, by NMDA receptors, which are complexes consisting of the subunit NMDAR1 (NR1) and one or more NMDAR2 subunits (NR2A- NR2D). We made a polyclonal antibody to a C-terminus peptide of NR2A. In analysis of transfected cell membranes, this antibody recognizes NR2A and NR2B, and to a slight extent, NR2C and NR2D. In Western blots of rat brain, the antibody labeled a single band that comigrated with NR2A and NR2B. This antibody (NR2A/B) did not cross-react with extracts from transfected cells expressing other glutamate receptor subunits, nor did it label non-neuronal tissues. Immunostained sections of rat brain showed significant staining throughout the nervous system, including olfactory bulb, cerebral cortex, hippocampus, caudate- putamen, and many brainstem nuclei, as well as in neurons of spinal cord and sensory ganglia. This widespread distribution of staining was similar to that found with an antibody to NR1, supporting the presence of functional NR1/NR2 complexes throughout the nervous system. In the cerebellum, in contrast to staining with NR1 antibody, Purkinje cell staining with NR2A/B antibody was low, indicating that these neurons may lack functional NMDA receptors. EM examination revealed dense staining in dendrites and postsynaptic densities in cerebral cortex and hippocampus, similar to those seen with antibody to NR1. Since functional NMDA receptor complexes at synapses appear to require both NR1 and NR2 subunit proteins for full function, this study provides structural evidence for functional NR1/NR2 receptors in vivo in the nervous system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - excitatory amino acids
KW  - ultrastructure
KW  - immunocytochemistry
KW  - AMPA
KW  - hippocampus
KW  - cerebellum
KW  - 1994
KW  - Amino Acids
KW  - Hippocampus
KW  - N-Methyl-D-Aspartate
KW  - Immunocytochemistry
KW  - Cerebellum
KW  - Rats
KW  - AMPA
KW  - 1994
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Khochbin, Saadi
AU  - Wolffe, Alan P.
T1  - Developmentally regulated expression of linker-histone variants in vertebrates.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/10/15/
VL  - 225
IS  - 2
M3  - Article
SP  - 501
EP  - 510
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The identification of histone H1 variants in vertebrates suggests that these proteins may have specialized functions. During embryonic development, a correspondence between the expression of each of the linker-histone variants and the proliferative and transcriptional activity of embryonic cells can be observed. Analysis of the developmentally regulated expression of these variants leads to the subdivision of these variants into distinct classes. This subdivision may also provide insight into the significance of the differential expression of variants and the roles individual linker histones have in chromatin structure and function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VERTEBRATES
KW  - HISTONES
KW  - EMBRYOLOGY
KW  - BASIC proteins
KW  - CHORDATA
KW  - GENETICS
N1  - Accession Number: 12286425; Khochbin, Saadi 1 Wolffe, Alan P. 2; Affiliation:  1: Labotratoire de Biologie Moleculaire di Cycle Cellulaire, INSERM U309, CEA/DBMS/CEN-G, Grenoble, France.  2: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NHS, Bldg. 6, Rm. B1A-13, Bethseda, USA.; Source Info: 10/15/94, Vol. 225 Issue 2, p501; Subject Term: VERTEBRATES; Subject Term: HISTONES; Subject Term: EMBRYOLOGY; Subject Term: BASIC proteins; Subject Term: CHORDATA; Subject Term: GENETICS; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Konkel, Michael E.
AU  - Marconi, Richard T.
AU  - Mead, David J.
AU  - Cieplak Jr., Witold
T1  - Identification and characterization of an intervening sequence within the 23S ribosomal RNA genes of Campylobacter jejuni.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1994/10/15/
VL  - 14
IS  - 2
M3  - Article
SP  - 235
EP  - 241
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - <em>Campylobacter jejuni</em> is a significant cause of bacterial enteritis in humans. Three of seven <em>C. jejuni</em> isolates examined were found to contain fragmented 23S rRNA. The occurrence of fragmented 23S rRNA correlated with the presence of an intervening sequence (IVS) within the 23S rRNA genes. The IVS is 157 nucleotides in length and replaces an eight nucleotide sequence in the 23S rRNA germs of <em>C. jejuni</em> isolates that contain intact 23S rRNA. The two ends of the IVS share 31 bases of complementarity that could form a stem-loop structure. Fragmentation of the 23S ribosomal RNA results from the excision of the IVS from the transcribed RNA; the 3' cleavage site maps within the putative stem-loop formed by the IVS. Southern hybridization analysis revealed that the IVS is not present in the genomes of isolates that contain intact 23S rRNA, suggesting that the IVS is not derived from <em>Campylobacter</em> chromosomal sequences. The <em>C. jejuni</em> IVS is located at a position analogous to that of the IVSs found in both <em>Salmonella</em> and <em>Yersinia</em> spp. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Campylobacter jejuni
KW  - RNA
KW  - Intestinal diseases
KW  - Genes
KW  - Nucleotide sequence
N1  - Accession Number: 16065812; Konkel, Michael E. 1; Marconi, Richard T. 1; Mead, David J. 1; Cieplak Jr., Witold 1; Affiliations: 1: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; Issue Info: Oct1994, Vol. 14 Issue 2, p235; Thesaurus Term: Campylobacter jejuni; Thesaurus Term: RNA; Subject Term: Intestinal diseases; Subject Term: Genes; Subject Term: Nucleotide sequence; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107400624
T1  - Nutritional risk factors for cardiovascular disease: assessment and intervention.
AU  - Donato K
AU  - Newman E
Y1  - 1994/11//1994 Nov
N1  - Accession Number: 107400624. Language: English. Entry Date: 19950301. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8608669. 
KW  - Cardiovascular Risk Factors
KW  - Nutritional Assessment
KW  - Cardiovascular Diseases -- Diagnosis
KW  - Cardiovascular Diseases -- Diet Therapy
KW  - Weight Control
KW  - Obesity
KW  - Cholesterol
KW  - Occupational Health Nursing
KW  - Hypercholesterolemia
KW  - Diet
KW  - United States
KW  - Education, Continuing (Credit)
KW  - Dietary Fats
KW  - Diet Therapy
KW  - Male
KW  - Female
SP  - 555
EP  - 562
JO  - AAOHN Journal
JF  - AAOHN Journal
JA  - AAOHN J
VL  - 42
IS  - 11
CY  - Thorofare, New Jersey
PB  - SLACK Incorporated
SN  - 0891-0162
AD  - National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 7695801.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104782100
T1  - Alcohol consumption, alcohol abuse and alcohol dependence. The United States as an example.
AU  - Grant, B F
Y1  - 1994/11//
N1  - Accession Number: 104782100. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Alcoholism -- Epidemiology
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Alcohol Drinking
KW  - Alcoholism -- Classification
KW  - Alcoholism -- Diagnosis
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Incidence
KW  - Male
KW  - Middle Age
KW  - Psychological Tests
KW  - United States
SP  - 1357
EP  - 1365
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 89
IS  - 11
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This paper presents national estimates of alcohol consumption and DSM-IV alcohol abuse and dependence in the United States. Fifty-two percent of the adults surveyed were classified as current drinkers and nearly 9.0% met criteria for DSM-IV alcohol abuse or dependence. Greater percentages of males and whites were classified as current drinkers and as alcohol abusers or dependent, compared with females and non-whites, respectively. There is a need for future epidemiological research to collect better data on drinking patterns as an aid to interpreting socio-demographic differentials and to estimate more precisely the association between alcohol consumption and abuse and dependence in multivariate statistical environments. The critical need to examine the unprecedented reversal of the abuse-to-dependence ratio resulting from the application of the DSM-IV classification is emphasized. The role of future longitudinal alcohol epidemiological research in elucidating the initiation and maintenance of consumption patterns and alcohol use disorders is stressed.
SN  - 0965-2140
AD  - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20892.
U2  - PMID: 7841843.
DO  - 10.1111/j.1360-0443.1994.tb03730.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Obarzanek, Eva
AU  - Lesem, Michael D.
AU  - Jimerson, David C.
T1  - Resting metabolic rate of anorexia nervosa patients during weight gain.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/11//
VL  - 60
IS  - 5
M3  - Article
SP  - 666
EP  - 675
SN  - 00029165
AB  - To determine whether changes in energy metabolism may contribute to the difficulty of weight gain observed in anorexic patients, resting metabolic rate (RMR) and neuroendocrine function were studied in 10 patients diagnosed with anorexia nervosa. RMR per kilogram lean body mass (±SEM) was not significantly different from that of healthy volunteers on admission (95.9 ± 5.6 vs 103.6 ± 3.3 kJ/kg, respectively), during early refeeding (108.6 ± 6.9 kJ/kg), or at target weight (102.1 ± 3.8 kJ/kg). At late refeeding RMR was significantly higher (132.1 ± 4.9 kJ/kg, P < 0.0001). There were no significant correlations between plasma norepinephrine and thyroid hormones and RMR. The rise in RMR during refeeding is at least double that observed in other studies in which normal-weight subjects are experimentally overfed or experimentally underfed and then refed. These results suggest that the increase in RMR during refeeding is disproportionate to weight gain and this large magnitude of increase may be unique to anorexia nervosa. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Anorexia nervosa
KW  - energy metabolism
KW  - resting metabolic rate
KW  - thermogenesis
N1  - Accession Number: 94403911; Obarzanek, Eva 1; Lesem, Michael D. 1; Jimerson, David C. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD; Issue Info: Nov1994, Vol. 60 Issue 5, p666; Author-Supplied Keyword: Anorexia nervosa; Author-Supplied Keyword: energy metabolism; Author-Supplied Keyword: resting metabolic rate; Author-Supplied Keyword: thermogenesis; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107421520
T1  - Resting metabolic rate of anorexia nervosa patients during weight gain.
AU  - Obarzanek E
AU  - Lesem MD
AU  - Jimerson DC
Y1  - 1994/11//
N1  - Accession Number: 107421520. Language: English. Entry Date: 19950901. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by US Public Health Service training grant F32-MH09183. NLM UID: 0376027. 
KW  - Anorexia Nervosa -- Metabolism
KW  - Energy Metabolism
KW  - Weight Gain
KW  - Behavior Modification
KW  - Body Composition
KW  - Energy Intake
KW  - T-Tests
KW  - Comparative Studies
KW  - Thyroid Hormones
KW  - Norepinephrine
KW  - Funding Source
KW  - Inpatients
KW  - Female
KW  - Human
SP  - 666
EP  - 675
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 60
IS  - 5
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Federal Bldg, Room 604, Bethesda, MD 20892
U2  - PMID: 7942571.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Morrison, John A.
AU  - Payne, Gerald
AU  - Barton, Bruce A.
AU  - Khoury, Philip R.
AU  - Crawford, Pat
T1  - Mother-Daughter Correlations of Obesity and Cardiovascular Disease Risk Factors in Black and White Households: The NHLBI Growth and Health Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/11//
VL  - 84
IS  - 11
M3  - Article
SP  - 1761
EP  - 1761
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study sought to evaluate obesity as a potential explanatory factor for the increased relative risk for cardiovascular disease in Black compared with White women. Methods. Familial associations for obesity and cardiovascular disease risk factors were assessed in 720 White and 580 Black mother-daughter pairs from the National Heart, Lung, and Blood Institute's Growth and Health Study by using Pearson's chi square, Spearman's correlations and partial correlations. Results. Black girls and mothers were significantly heavier and had higher body mass indices than their Whiter counterparts. In each racial group, significant, positive mother-daughter correlations existed for weight, body mass index, and triceps skinfolds, and for all cardiovascular disease risk factors. Obesity measures correlated positively with systolic blood pressure and triglycerides and inversely with high-density lipoprotein cholesterol in girls and mothers of both races. Correlations between mothers and daughters for exercise and ideal body shape were weak and did not explain obesity associations. Conclusions. Intrafamilial associations of obesity, cardiovascular disease risk factors, and the obesity cardiovascular disease risk factor relationship support the position that increased cardiovascular disease morbidity and mortality rates in Black women may be linked to excess obesity in Black women compared with White Ones. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OBESITY
KW  - CARDIOVASCULAR diseases
KW  - DISEASES -- Risk factors
KW  - MOTHERS & daughters
KW  - BODY mass index
N1  - Accession Number: 9411285520; Morrison, John A. 1,2 Payne, Gerald 3 Barton, Bruce A. 4 Khoury, Philip R. 1 Crawford, Pat 5; Affiliation:  1: Division of Cardiology, Children's Hospital Medical Center, Cincinnati, Ohio  2: Department of Pediatrics, University of Cincinnati College of Medicine  3: National Heart, Lung and Blood Institute of Bethesda  4: Maryland Medical Research Institute, Baltimore, Md.  5: Public Health, University of California, Berkeley; Source Info: Nov94, Vol. 84 Issue 11, p1761; Subject Term: OBESITY; Subject Term: CARDIOVASCULAR diseases; Subject Term: DISEASES -- Risk factors; Subject Term: MOTHERS & daughters; Subject Term: BODY mass index; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wagner-Echeagaray, Fernando A.
AU  - Schütz, Christian G.
AU  - Chilcoat, Howard D.
AU  - Anthony, James C.
T1  - Degree of Acculturation and the Risk of Crack Cocaine Smoking among Hispanic Americans.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/11//
VL  - 84
IS  - 11
M3  - Article
SP  - 1825
EP  - 1825
PB  - American Public Health Association
SN  - 00900036
AB  - Epidemiologic data from three national surveys conducted in 1988, 1990, and 1991 were used to investigate the association between acculturation and use of crack cocaine among Hispanic Americans living in the United States. Poststratification and conditional logistic regression were used to hold constant shared aspects of neighborhood environment, age, sex, and education. The analyses showed a strong inverse relationship between degree of acculturation and crack smoking among Mexican Americans (relative odds = 0.12, 95% confidence interval = 0.04, 0.34) but not among other Hispanics in the study population. This observed variation within the US Hispanic American population deserves special attention in future research. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ACCULTURATION
KW  - COCAINE abuse
KW  - HISPANIC Americans
KW  - HEALTH surveys -- United States
KW  - UNITED States
N1  - Accession Number: 9411285532; Wagner-Echeagaray, Fernando A. 1 Schütz, Christian G. 2 Chilcoat, Howard D. 2 Anthony, James C. 3; Affiliation:  1: Centros de Integracion Juvenil, Mexico City Mexico  2: National Institutes of Health/National Institute on Drug Abuse Addiction Research Center, Baltimore, Md.  3: Department of Mental Hygiene, The Johns Hopkins School of Hygiene and Public Health, Baltimore; Source Info: Nov94, Vol. 84 Issue 11, p1825; Subject Term: ACCULTURATION; Subject Term: COCAINE abuse; Subject Term: HISPANIC Americans; Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gorse, G. J.
AU  - Schwartz, D. N.
AU  - Graham, B. S.
AU  - Matthews, T. J.
AU  - Stablein, D. M.
AU  - Frey, S. E.
AU  - Belshe, R. B.
AU  - Clements, M. L.
AU  - Wright, P. F.
AU  - Eibl, M.
AU  - Fast, P. E.
T1  - HIV-1 recombinant gp160 vaccine given in accelerated dose schedules.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1994/11//
VL  - 98
IS  - 2
M3  - Article
SP  - 178
EP  - 184
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The purpose of this randomized, double-blind study was to test the safety and immunogenicity of an HIV-1LAI recombinant gp160 (rgp160) vaccine in healthy, uninfected volunteers using accelerated dosing schedules. Thirty volunteers were randomly assigned to receive 50-μg doses of rgp 160 in one of two immunization schedules. Group 1 received rgp160 at times 0, 1, 2 and 5 months; and group 2 received rgp160 at times 0, 1, 2, 3 and 4 months. The vaccine was safe and stimulated high levels of HIV-1 envelope-specific binding antibody and T cell memory. There was a trend (P < 0.10) suggesting neutralizing antibodies were better induced by the regimen incorporating a rest period before the final immunization in group 1 volunteers. Both accelerated immunization schedules induced immune responses at levels similar to or better than those achieved by four rgp160 vaccine injections given over 12 - 18 months in other studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNITY
KW  - PREVENTIVE medicine
KW  - VACCINATION
KW  - IMMUNIZATION
KW  - T cells
KW  - IMMUNE response
KW  - HIV-1 envelope glycoprotein
KW  - humoral
KW  - immunity
KW  - immunogenicity
KW  - lymphocyte proliferation
KW  - Vaccine
N1  - Accession Number: 15985332; Gorse, G. J. 1 Schwartz, D. N. 2 Graham, B. S. 3 Matthews, T. J. 4 Stablein, D. M. 5 Frey, S. E. 1 Belshe, R. B. 1 Clements, M. L. 2 Wright, P. F. 3 Eibl, M. 6 Fast, P. E. 7; Affiliation:  1: The NIAID AIDS Vaccine Clinical Trials Network Division of Infectious Disease, Department of Internal Medicine, Saint Louis University School of Medicine and St Louis Department of Veterans Affairs Medical Centre, St Louis, MO.  2: Centre for Immunization Research, Johns Hopkins University, Baltimore. MD.  3: Department of Medicine, Vanderbilt University School of Medicine, Nashvilie, TN.  4: Department of Paediatrics, Vanderbilt University School of Medicine, Nashvilie, TN.  5: Department of Surgery Duke University School of Medicine, Durham. NC.  6: The EMMES Corporation, Potomac, MD, USA.  7: Division of AIDS, Vaccine Research and Development Branch, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.; Source Info: Nov1994, Vol. 98 Issue 2, p178; Subject Term: IMMUNITY; Subject Term: PREVENTIVE medicine; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: T cells; Subject Term: IMMUNE response; Author-Supplied Keyword: HIV-1 envelope glycoprotein; Author-Supplied Keyword: humoral; Author-Supplied Keyword: immunity; Author-Supplied Keyword: immunogenicity; Author-Supplied Keyword: lymphocyte proliferation; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
T1  - Openness to Experience: expanding the boundaries of Factor V.
JO  - European Journal of Personality
JF  - European Journal of Personality
Y1  - 1994/11//
VL  - 8
IS  - 4
M3  - Article
SP  - 251
EP  - 272
PB  - John Wiley & Sons, Inc.
SN  - 08902070
AB  - The fifth factor in lexical studies of trait adjectives is commonly interpreted as Intellect, whereas the corresponding factor derived from questionnaire studies is typical identified as Openness to Experience. Intellect as a construct is problematic because it erroneously suggests an equivalence of Factor V with intelligence, describes aspects of Factor III (Conscientiousness) as well as of Factor V, and fails to suggest the diverse psychological correlates that Factor V is known to have. By contrast, Openness to Experience is a broader construct that implies both receptivity to many varieties of experience and a fluid and permeable structure of consciousness. Data from analyses of adjectives, established personality questionnaires, and Hartnmann's (1991) new Boundary Questionnaire support these interpretations. The construct of Openness can he transported across geographical and cultural boundaries to function as a universal dimension of personality structure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Personality is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTELLECT
KW  - PERSONALITY
KW  - PSYCHOLOGICAL factors
KW  - PERSONALITY tests
KW  - INTELLIGENCE levels
KW  - CONSCIOUSNESS
KW  - CULTURAL boundaries
N1  - Accession Number: 12088434; McCrae, Robert R. 1; Affiliation:  1: Gerontology Reseatch Center, National Institute on Aging, NIH, Baltimore. MD, U.S.A.; Source Info: Nov94, Vol. 8 Issue 4, p251; Subject Term: INTELLECT; Subject Term: PERSONALITY; Subject Term: PSYCHOLOGICAL factors; Subject Term: PERSONALITY tests; Subject Term: INTELLIGENCE levels; Subject Term: CONSCIOUSNESS; Subject Term: CULTURAL boundaries; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107402735
T1  - Quality assurance in health education.
AU  - Mail PD
Y1  - 1994/11//1994 Nov-Dec
N1  - Accession Number: 107402735. Language: English. Entry Date: 19950401. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137. 
KW  - Professional Development
KW  - Health Education
KW  - Credentialing Examinations
KW  - Quality Assurance
KW  - Health Educators
KW  - Professional Competence
KW  - Maryland
KW  - Information Resources
SP  - 333
EP  - 337
JO  - Journal of Health Education
JF  - Journal of Health Education
JA  - J HEALTH EDUC
VL  - 25
IS  - 6
CY  - Reston, Virginia
PB  - American Alliance for Health, Physical Education, Recreation & Dance
AB  - The mechanisms by which the profession of health education is seeking to promote increased competency, visibility, marketability, and quality among practitioners include professional preparation with a health education emphasis, certification by examination, and recertification with a specified number of continuing education contact hours. These requirements are not without critics and concerns. A discussion about examination construction and the benefits of continuing education are provided to help clarify some of the key concepts in the health education credentialing movement.
SN  - 1055-6699
AD  - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20850
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Richard, Gabriele
AU  - Wright, Andrea R.
AU  - Harris, Sheryl
AU  - Doyle, Sharon Z.
AU  - Korge, Bernhard
AU  - Mazzanti, Cinzia
AU  - Tanaka, Toshihiro
AU  - Harth, Wolfgang
AU  - McBride, O. Wesley
AU  - Compton, John G.
AU  - Bale, Sherri J.
AU  - Digiovanna, John J.
T1  - Fine Mapping of the Darier's Disease Locus on Chromosome 12q.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/11//
VL  - 103
IS  - 5
M3  - Article
SP  - 665
EP  - 668
SN  - 0022202X
AB  - Darier's disease (DD) is an autosomal dominant genodermatosis characterized by epidermal acantholysis and dyskeratosis. We have performed genetic linkage studies in 10 families with DD (34 affected) by analyzing 14 polymorphic microsatellite markers. Our suits confirm recent reports mapping the DD gene to chromosome 12q23-q24.l. Haplotype analysis of recombinant chromosomes in our families, along with previously reported data, narrow the location of the DD gene to a 5 cM interval flanked by the loci D12S354 and D12S84/D12S105. This localization allowed exclusion of two known genes, PLA2A and PAH, as candidate loci for DD. Three other gene loci (PPP1C, PMCH, PMCA1), mapping in 12q21-q24, remain potential candidates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATOSIS follicularis
KW  - CHROMOSOMES
KW  - SKIN diseases -- Genetic aspects
KW  - EPIDERMIS
KW  - MICROSATELLITES (Genetics)
KW  - CELL nuclei
KW  - <em>epidermis</em>
KW  - <em>genodermatosis</em>
KW  - <em>keratosis follicularis</em>
KW  - <em>linkage</em>
N1  - Accession Number: 12398429; Richard, Gabriele 1 Wright, Andrea R. 1 Harris, Sheryl 1 Doyle, Sharon Z. 1 Korge, Bernhard 1 Mazzanti, Cinzia 2 Tanaka, Toshihiro 3 Harth, Wolfgang 4 McBride, O. Wesley 5 Compton, John G. 1 Bale, Sherri J. 2 Digiovanna, John J. 6; Affiliation:  1: Genetic Studies Section, Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Istituto Dermopatico dell'Immacolata, Rome, Italy  3: Department of Dermatology, Kyoto University, Kyoto, Japan  4: Hautklinik, Erfurt, Germany  5: Department of Cell Biology, New York University Medical Center, New York, New York, U.S.A  6: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov94, Vol. 103 Issue 5, p665; Subject Term: KERATOSIS follicularis; Subject Term: CHROMOSOMES; Subject Term: SKIN diseases -- Genetic aspects; Subject Term: EPIDERMIS; Subject Term: MICROSATELLITES (Genetics); Subject Term: CELL nuclei; Author-Supplied Keyword: <em>epidermis</em>; Author-Supplied Keyword: <em>genodermatosis</em>; Author-Supplied Keyword: <em>keratosis follicularis</em>; Author-Supplied Keyword: <em>linkage</em>; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12398429
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ruhl, Kimberly K.
AU  - Pomidor, Mary M.
AU  - Rhim, Johng S.
AU  - Tuan, Rocky S.
AU  - Hickok, Noreen J.
T1  - Post-Transcriptional Suppression of Human Ornithine Decarboxylase Gene Expression by Phorbol Esters in Human Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/11//
VL  - 103
IS  - 5
M3  - Article
SP  - 687
EP  - 692
SN  - 0022202X
AB  - The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol- 13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types. However, in cultured human epidermal cells, TPA has been reported to be antiproliferative. Therefore, to elucidate pathways that TPA activates in cultured human skin cells, we have examined the levels at which TPA regulates ornithine decarboxylase gene expression in two immortalized human epidermal keratinocyte cell lines, and in normal neonatal keratinocytes. We have found that in cultured human keratinocytes, TPA causes a marked decrease in ornithine decarboxylase enzyme activity (50-90%), with no detectable effect on ornithine decarboxylase mRNA levels. TPA decreased steady-state levels of ornithine decarboxylase immunoreactive protein (∼ 50-67%), accounting for the 50-90% suppression of ornithine decarboxylase activity levels, as well as decreasing new synthesis of ornithine decarboxylase protein (48-50%). However, measurement of ornithine decarboxylase protein half-life showed no significant effect of TPA. Also, prolonged treatment of keratinocytes with phorbol esters abolished the suppression of ornithine decarboxylase activity by TPA. Our data, therefore, suggest that phorbol esters suppress ornithine decarboxylase gene expression predominantly by decreasing ornithine decarboxylase mRNA translatability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ORNITHINE decarboxylase
KW  - GENE expression
KW  - PHORBOLS
KW  - KERATINOCYTES
KW  - DECARBOXYLASES
KW  - MESSENGER RNA
KW  - <em>TPA</em>
N1  - Accession Number: 12398542; Ruhl, Kimberly K. 1,2 Pomidor, Mary M. 1,2 Rhim, Johng S. 3 Tuan, Rocky S. 2,4 Hickok, Noreen J. 1,2; Affiliation:  1: Department of Dermatology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania  2: Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania  3: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.  4: Department of Orthopaedic Surgery, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania; Source Info: Nov94, Vol. 103 Issue 5, p687; Subject Term: ORNITHINE decarboxylase; Subject Term: GENE expression; Subject Term: PHORBOLS; Subject Term: KERATINOCYTES; Subject Term: DECARBOXYLASES; Subject Term: MESSENGER RNA; Author-Supplied Keyword: <em>TPA</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12398542
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107412906
T1  - Variability in percent energy from fat throughout the day: implications for application of total diet goals.
AU  - Ballard-Barbash R
AU  - Thompson FE
AU  - Graubard BI
AU  - Krebs-Smith SM
Y1  - 1994/11//Nov/Dec94
N1  - Accession Number: 107412906. Language: English. Entry Date: 19950701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. NLM UID: 0246004. 
KW  - Energy Metabolism
KW  - Dietary Fats
KW  - Energy Intake -- Evaluation
KW  - Multi-Stage Cluster
KW  - Probability Sample
KW  - Diaries
KW  - Interviews
KW  - Surveys
KW  - Data Analysis -- Methods
KW  - Descriptive Statistics
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Human
SP  - 278
EP  - 283
JO  - Journal of Nutrition Education
JF  - Journal of Nutrition Education
JA  - J NUTR EDUC
VL  - 26
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
SN  - 0022-3182
AD  - Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 343, 6130 Executive Blvd MSC 7344, Bethesda, MD 20892-7344
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107412906&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107427612
T1  - Organic brain syndromes and opioid administration for cancer pain.
AU  - Caraceni A
AU  - Martini C
AU  - De Conno F
AU  - Ventafridda V
Y1  - 1994/11//1994 Nov
N1  - Accession Number: 107427612. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article; case study; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. Grant Information: CNR grant N 92.02367.PF39. NLM UID: 8605836. 
KW  - Organic Mental Disorders, Psychotic
KW  - Narcotics -- Therapeutic Use
KW  - Cancer Pain -- Drug Therapy
KW  - Funding Source
KW  - Organic Mental Disorders, Psychotic -- Etiology
KW  - Narcotics -- Adverse Effects
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 527
EP  - 533
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 9
IS  - 8
CY  - New York, New York
PB  - Elsevier Science
AB  - To clarify the range of potential etiologies that may contribute to organic brain syndrome in patients receiving systemic opioids for cancer pain, we describe 15 patients who presented this complication. In 11 cases, concomitant conditions were found that could contribute to the onset of organic brain syndrome. These data illustrate that multiple causes often play a role in the development of mental status changes in advanced cancer. Opioids are seldom the only causal factor implicated. (Reprinted by permission of Elsevier Science Publishing Co., Inc. Copyright 1995 by the U.S. Cancer Pain Relief Committee)
SN  - 0885-3924
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute, Via Venezian I, 20133, Milan, Italy
U2  - PMID: 7531737.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107427612&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850749
T1  - Nutritional prediction of pressure ulcers.
AU  - Breslow RA
AU  - Bergstrom N
Y1  - 1994/11//
N1  - Accession Number: 105850749. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Nutritional Status
KW  - Pressure Ulcer -- Etiology
KW  - Protein-Energy Malnutrition -- Complications
KW  - Cross Sectional Studies
KW  - Dietary Proteins -- Administration and Dosage
KW  - Energy Intake
KW  - Hospitals
KW  - Nursing Homes
KW  - Pressure Ulcer -- Prevention and Control
KW  - Prospective Studies
KW  - Risk Factors
KW  - Human
SP  - 1301
EP  - 1306
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 94
IS  - 11
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - National Cancer Institute, Cancer Prevention Fellowship Office, Rockville, MD 20892.
U2  - PMID: 7963176.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850749&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107394686
T1  - Frailty and disability: can growth hormone or other trophic agents make a difference?
AU  - Hodes RJ
Y1  - 1994/11//11/ 1/1994
N1  - Accession Number: 107394686. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Neuropeptides -- Therapeutic Use -- In Old Age
KW  - Disabled -- In Old Age
KW  - Frail Elderly
KW  - Human Growth Hormone -- Therapeutic Use -- In Old Age
KW  - Human Growth Hormone -- Pharmacodynamics -- In Old Age
KW  - Age Factors
KW  - Aging -- Physiology
KW  - Body Composition -- Drug Effects -- In Old Age
KW  - Clinical Trials
KW  - Combined Modality Therapy -- In Old Age
KW  - Drug Synergism
KW  - Drug Therapy, Combination -- In Old Age
KW  - Estrogens -- Pharmacodynamics -- In Old Age
KW  - Estrogens -- Therapeutic Use -- In Old Age
KW  - Therapeutic Exercise
KW  - Growth Substances -- Physiology -- In Old Age
KW  - National Institutes of Health (U.S.)
KW  - Aged
KW  - Male
KW  - Female
KW  - Human Growth Hormone -- Physiology -- In Old Age
KW  - Testosterone -- Pharmacodynamics -- In Old Age
KW  - Testosterone -- Therapeutic Use -- In Old Age
KW  - Neuropeptides -- Pharmacodynamics -- In Old Age
SP  - 1208
EP  - 1211
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - National Institute on Aging, Office of the Director, Bldg 31, Rm 5C35, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 7963210.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107394686&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Xiao, J.
AU  - Melton, R. E.
AU  - Kieser, T.
T1  - High-frequency homologous plasmid-plasmid recombination coupled with conjugation of plasmid SCP2* in Streptomyces.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1994/11//
VL  - 14
IS  - 3
M3  - Article
SP  - 547
EP  - 555
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Non-transmissible derivatives of the <em>Streptomyces</em> multi-copy plasmid pIJ101 were mobilized, by cointegrate formation, at frequencies approaching 100% (measured per recipient) by derivatives of the conjugative, low-copy-number <em>Streptomyces coelicolor</em> A3(2) plasmid SCP2*. Efficient co-integrate formation required that the plasmids shared at least 112 bp sequence identity, and it occurred only during conjugation. An SCP2* plasmid gene is involved in the process. Co-integrates were presumably formed in the donor cells and transported to the recipient cells. This is a new phenomenon, not known in other bacteria. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Gram-positive bacteria
KW  - Plasmids
KW  - Streptomyces coelicolor
KW  - Genes
KW  - Chromosomes
N1  - Accession Number: 19548827; Xiao, J. 1,2; Melton, R. E. 1; Kieser, T. 1; Email Address: Kieser@UK.AC.BBSRC; Affiliations: 1: John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK; 2: Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Nov1994, Vol. 14 Issue 3, p547; Thesaurus Term: Gram-positive bacteria; Subject Term: Plasmids; Subject Term: Streptomyces coelicolor; Subject Term: Genes; Subject Term: Chromosomes; Number of Pages: 9p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104782525
T1  - Inflammation and hyperalgesia in rats neonatally treated with capsaicin: effects on two classes of nociceptive neurons in the superficial dorsal horn.
AU  - Ren, K
AU  - Williams, G M
AU  - Ruda, M A
AU  - Dubner, R
Y1  - 1994/11//1994 Nov
N1  - Accession Number: 104782525. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Animal Population Groups -- Physiology
KW  - Capsaicin
KW  - Hyperalgesia -- Pathology
KW  - Inflammation -- Pathology
KW  - Nociceptors -- Physiology
KW  - Spinal Cord -- Physiology
KW  - Animals
KW  - Behavior, Animal
KW  - Hydrocarbons -- Pharmacodynamics
KW  - Electric Stimulation
KW  - Female
KW  - Solutions
KW  - Hyperalgesia -- Chemically Induced
KW  - Hyperalgesia -- Psychosocial Factors
KW  - Immunohistochemistry
KW  - Inflammation -- Chemically Induced
KW  - Microscopy, Electron
KW  - Nerve Fibers -- Physiology
KW  - Nerve Fibers
KW  - Neurons, Afferent -- Drug Effects
KW  - Neurons, Afferent -- Physiology
KW  - Physical Stimulation
KW  - Rats
KW  - Spinal Cord -- Pathology
SP  - 287
EP  - 300
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 59
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
U2  - PMID: 7892027.
DO  - 10.1016/0304-3959(94)90082-5
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104782525&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107405884
T1  - Test your radiologic skill. Airway compromise in two patients with aplastic anemia and coagulation abnormalities.
AU  - Gleaton LD
AU  - Ognibene FP
Y1  - 1994/11//1994 Nov
N1  - Accession Number: 107405884. Language: English. Entry Date: 19950501. Revision Date: 20150819. Publication Type: Journal Article; case study. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7510357. 
KW  - Anemia, Aplastic -- Complications
KW  - Airway Obstruction -- Etiology
KW  - Airway Obstruction -- Diagnosis
KW  - Airway Management
KW  - Radiography, Thoracic
KW  - Neck -- Radiography
KW  - Middle Age
KW  - Female
SP  - 1051
EP  - 1056
JO  - Respiratory Care
JF  - Respiratory Care
JA  - RESPIR CARE
VL  - 39
IS  - 11
CY  - Irving, Texas
PB  - Daedalus Enterprises, Inc.
SN  - 0020-1324
AD  - Critical Care Medicine Dept, Warren G Magnuson Clinical Center, National Institutes of Health, 10 Center Dr, MSC 1662, Bldg 10, Room 7D43, Bethesda MD 20892-1662
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107405884&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Walmsley, Elizabeth
AU  - Metzger, Catherine
AU  - Delaney, John K.
AU  - Fletcher, Colin
T1  - IMPROVED VISUALIZATION OF UNDERDRAWINGS WITH SOLID-STATE DETECTORS OPERATING IN THE INFRARED.
JO  - Studies in Conservation
JF  - Studies in Conservation
Y1  - 1994/11//
VL  - 39
IS  - 4
M3  - Article
SP  - 217
EP  - 231
SN  - 00393630
AB  - A series of experiments is described, the aim of which is to identify the optimum spectral band and detector configuration for the visualization of underdrawings. First, the visualization of underdrawings is investigated using three detector systems operating in different infrared spectral bands from 0.9 to 2-5µm. Visibility analysis is applied to the examination of eight test panels, each having a rectangle of paint covering six different underdrawing materials. These data demonstrate that the combined optical properties of the pigment and the underdrawing material determine which spectral band gives the optimum visualization of the underdrawing. The peak visibilities of different combinations occur between 1.0 and 2.5gm. These results suggest that camera systems having uniform spectral responsivity across the l.0 to 2.5pro band would be most useful for infrared reflectography (IRR). Second, the imaging properties of each camera system are investigated. Comparison of the modulation transfer function (MTF) and signal-to-noise ratio for the vidicon and the platinum silicide (PtSi) camera systems shows that the latter is much closer to a theoretically perfect system. Finally, the applicability of the visibility studies and MTF modeling to the IRR application is demonstrated by the examination of two paintings with the PtSi camera, which renders dramatically improved images of underdrawings and paint changes, as compared to reflectograms obtained with the vidicon camera. The implications of this study, including the potential use of infrared reflectography as a method of non-destructive analysis, are discussed. (English) [ABSTRACT FROM AUTHOR]
AB  - On décrit une série d'expériences destinée à identifier la bande spectrale optimale et la forme du détecteur pour la mise en évidence des dessins sous-jacents. En premier lieu, celle-ci est étudiée en employant trois systèmes de détecteurs opérant dans différentes bandes spectrales de 0,9 à 2,5µm. Les résultats suggèrent que les systèmes de caméra ayant une réponse uniforme entre la bande de 1,0 et 2,5µm seront les plus utiles dans la réflectographie infrarouge. Deuxièmement, les propriétés de chaque système de caméra ont été étudiées. Enfin, l'application des études de lisibilité et du modèle FTM (fonction du transfert de modulation) adapté à la caméra infrarouge est montrée par l'examen de deux peintures. On discute la portée de cette étude, compte-tenu de l'usage potentiel de la réflectographie infrarouge comme méthode d'analyse non destructive. (French) [ABSTRACT FROM AUTHOR]
AB  - Der Verfasser des Artikels beschreibt Reihenuntersuchungen, die zum Ziel haben, den optimalen Spektralbereich und die bestmögliche Aufnahmeanordnung zur Sichtbarmachung von Unterzeichnungen zu ermitteln. Es wurden drei verschiedene Aufnahmesysteme eingesetzt, die in unterschiedlichen Wellentängenbereichen von 0.9µm bis 2,5µm arbeiten. Die besten Ergebnisse lagen bei den hier vorgestellten Experimenten zwischen 1,0µm und 2,5µm. Demnach eignen sich Kamerasysteme mit einer gleichmäßigen Spektralempfindlichkeit in diesem Bereich besonders gut für die Infrarotreflektographie (IRR). Im zweitern Teil der Arbeit werden die bildgebenden Eigenschaften der Aufnahmesysteme untersucht. Die Umsetzung des MTF-(Modulationstransferfunktion) Modells und der experimentellen Studien zur Sichtbarmachung auf IRR-Anwendungen wird an Hand der Untersuchung zweier Gemälde. Diese Studie gewinnt besondere Bedeutung in der Diskussion über die Anwendung von IRR als zerstörungsfreie Untersuchungsmethode. (German) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Studies in Conservation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Infrared imaging
KW  - Underdrawing
KW  - Painting -- Expertising
KW  - Painting -- Conservation & restoration
KW  - Signal-to-noise ratio
KW  - Transfer functions (Mathematics)
KW  - Optical properties
N1  - Accession Number: 34577861; Walmsley, Elizabeth 1; Metzger, Catherine 1; Delaney, John K. 2; Fletcher, Colin 3; Affiliations: 1: Painting Conservation Department, National Gallery of Art, Washington, DC 20565, USA; 2: Department of Chemistry and Optical Sciences Center, University of Arizona, Tucson, AZ 85721, USA; 3: Laboratory of Mammalian Genetics, National Cancer Institute, Frederick, MD 21702, USA; Issue Info: Nov94, Vol. 39 Issue 4, p217; Thesaurus Term: Infrared imaging; Subject Term: Underdrawing; Subject Term: Painting -- Expertising; Subject Term: Painting -- Conservation & restoration; Subject Term: Signal-to-noise ratio; Subject Term: Transfer functions (Mathematics); Subject Term: Optical properties; Number of Pages: 15p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2008-13511-010
AN  - 2008-13511-010
AU  - Herrmann, Kathrin
AU  - Antonini, Antonella
AU  - Shatz, Carla J.
T1  - Ultrastructural evidence for synaptic interactions between thalamocortical axons and subplate neurons.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1994/11//
VL  - 6
IS  - 11
SP  - 1729
EP  - 1742
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Herrmann, Kathrin, Laboratory of Neurophysiology, National Institute of Mental Health, P.O. Box 608, Poolesville, MD, US, 20837
N1  - Accession Number: 2008-13511-010. PMID: 7874312 Partial author list: First Author & Affiliation: Herrmann, Kathrin; Laboratory of Neurophysiology, National Institute of Mental Health, Poolesville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20110131. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Herrmann, Kathrin. Major Descriptor: Axons; Neurons; Somatosensory Cortex; Thalamus; Visual Cortex. Minor Descriptor: Mammals; Synapses. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Nov, 1994. Publication History: Accepted Date: May 27, 1994; Revised Date: Nov 8, 1993; First Submitted Date: Sep 23, 1993. Copyright Statement: European Neuroscience Association
AB  - Thalamic axons are known to accumulate in the subplate for a protracted period prior to invading the cortical plate and contacting their ultimate targets, the neurons of layer 4. We have examined the synaptic contacts made by visual and somatosensory thalamic axons during the transition period in which axons begin to leave the subplate and invade the cortical plate in the ferret. We first determined when geniculocortical axons leave the subplate and begin to grow into layer 4 of the visual cortex by injecting 1,1'-dioctadecyl-3,3,3',3'-tetramethyl indocarbocyanine (Dil) into the lateral geniculate nucleus (LGN). By birth most LGN axons are still confined to the subplate. Over the next 10 days LGN axons grow into layer 4, but many axons retain axonal branches within the subplate. To establish whether thalamic axons make synaptic contacts within the subplate, the anterograde tracer PHA-L was injected into thalamic nuclei of neonatal ferrets between postnatal day 3 and 12 to label thalamic axons at the electron microscope level. The analysis of the PHA-L injections confirmed the Dil data regarding the timing of ingrowth of thalamic axons into the cortical plate. At the electron microscope level, PHA-L-labelled axons were found to form synaptic contacts in the subplate. The thalamic axon terminals were presynaptic primarily to dendritic shafts and dendritic spines. Between postnatal days 12 and 20 labelled synapses were also observed within layer 4 of the cortex. The ultrastructural appearance of the synapses did not differ significantly in the subplate and cortical plate, with regard to type of postsynaptic profiles, length of postsynaptic density or presynaptic terminal size. These observations provide direct evidence that thalamocortical axons make synaptic contacts with subplate neurons, the only cell type within the subplate possessing mature dendrites and dendritic spines; they also suggest that functional interactions between thalamic axons and subplate neurons could play a role in the establishment of appropriate thalamocortical connections. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - synaptic interactions
KW  - thalamocortical axons
KW  - subplate neurons
KW  - somatosensory thalamic axons
KW  - visual thalamic axons
KW  - ferrets
KW  - 1994
KW  - Axons
KW  - Neurons
KW  - Somatosensory Cortex
KW  - Thalamus
KW  - Visual Cortex
KW  - Mammals
KW  - Synapses
KW  - 1994
U1  - Sponsor: NATO. Recipients: Herrmann, Kathrin
U1  - Sponsor: Sponsor name not included. Other Details: Fight for Sight Postdoctoral Fellowships. Recipients: Herrmann, Kathrin
U1  - Sponsor: Alzheimer's Association. Recipients: Shatz, Carla J.
U1  - Sponsor: National Institutes of Health. Grant: EY02858. Recipients: Shatz, Carla J.
DO  - 10.1111/j.1460-9568.1994.tb00565.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13511-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-36369-037
AN  - 2015-36369-037
AU  - Everson, Carol A.
AU  - Smith, Carolyn Beebe
AU  - Sokoloff, Louis
T1  - Effects of prolonged sleep deprivation on local rates of cerebral energy metabolism in freely moving rats.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1994/11//
VL  - 14
IS  - 11
SP  - 6769
EP  - 6778
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Everson, Carol A., National Institute of Mental Health, Building 10, Room 4S-239, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-36369-037. PMID: 7965078 Partial author list: First Author & Affiliation: Everson, Carol A.; Clinical Psychobiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20160808. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Founding Congress of the World Federation of Sleep Research Societies, 1991, Cannes, France. Conference Note: Portions of this work were presented previously at the aforementioned conference. Major Descriptor: Cerebral Atrophy; Glucose; Sleep Deprivation. Minor Descriptor: Rats. Classification: Physiological Processes (2540). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Nov, 1994. Publication History: Accepted Date: May 10, 1994; Revised Date: Apr 27, 1994; First Submitted Date: Jan 25, 1994. Copyright Statement: Society for Neuroscience. 1994. 
AB  - Although sleep deprivation interferes with biological processes essential for performance, health, and longevity, previous studies have failed to reveal any structural or functional changes in brain. We have therefore measured local rates of cerebral glucose utilization (ICMRglc) with the quantitative autoradiographic 2–¹⁴C-deoxyglucose method in an effort to determine if and, if so, where sleep deprivation might affect function in sleep-deprived rats. Sleep deprivation was maintained for 11–12 d, long enough to increase whole body energy metabolism, thus confirming that pathophysiological processes that might involve brain functions were evolving. Deep brain temperature was also measured in similarly treated rats and found to be mildly elevated relative to core body temperature. Despite the increased deep brain temperature, systemic hypermetabolism, and sympathetic activation, ICMRglc was not elevated in any of the 60 brain structures examined. Average glucose utilization in the brain as a whole was unchanged in the sleep-deprived rats, but regional decreases were found. The most marked decreases in ICMRglc were in regions of the hypothalamus, thalamus, and limbic system. Mesencephalic and pontine regions were relatively unaffected except for the central gray area. The medulla was entirely normal. The effects of sleep deprivation on brain tended, therefore, to be unidirectional toward decreased energy metabolism, primarily in regions associated with mechanisms of thermoregulation, endocrine regulation, and sleep. Correspondence was found between the hypometabolic brain regions and some aspects of peripheral symptoms. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - sleep deprivation
KW  - brain
KW  - glucose utilization
KW  - whole-body metabolism
KW  - autoradiography
KW  - deoxyglucose
KW  - brain temperature
KW  - 1994
KW  - Cerebral Atrophy
KW  - Glucose
KW  - Sleep Deprivation
KW  - Rats
KW  - 1994
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-36369-037&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Thompson, Frances E.
AU  - Byers, Tim
T1  - Dietary Assessment Resource Manual.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1994/11/02/Nov94 Supplement
VL  - 124
M3  - Article
SP  - 2245S
EP  - 2250S
SN  - 00223166
AB  - The article offers information on the "Dietary Assessment Resource Manual." The manual is meant to serve as a resource for nutritionists and health professionals who wanted to assess diet in a study or as part of clinical services. Moreover, it is intended to assist health professionals to understand the advantages and disadvantages of alternative dietary assessment methods. The five families of assessment methods are reviewed and critiqued in the succeeding sections. These include: dietary records, 24-hour dietary recall, food frequency and brief dietary assessment methods.
KW  - DIETARIES
KW  - NUTRITION -- Study & teaching
KW  - NUTRITION -- Evaluation
KW  - HEALTH education
KW  - DIETITIANS
KW  - FOOD habits
KW  - DIET
KW  - REDUCING diets
KW  - DIETETIC foods
N1  - Accession Number: 22583959; Thompson, Frances E. 1 Byers, Tim 2; Affiliation:  1: National Cancer Institute, Division of Cancer Prevention and Control, Applied Research Branch, Bethesda, MD 20892-7344  2: Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition, Chronic Disease Prevention Branch, Atlanta, GA 30341-3724; Source Info: Nov94 Supplement, Vol. 124, p2245S; Subject Term: DIETARIES; Subject Term: NUTRITION -- Study & teaching; Subject Term: NUTRITION -- Evaluation; Subject Term: HEALTH education; Subject Term: DIETITIANS; Subject Term: FOOD habits; Subject Term: DIET; Subject Term: REDUCING diets; Subject Term: DIETETIC foods; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107299984
T1  - Educational attainment in long-term survivors of childhood acute lymphoblastic leukemia.
AU  - Haupt R
AU  - Fears TR
AU  - Robison LL
AU  - Mills JL
AU  - Nicholson HS
AU  - Zeltzer LK
AU  - Meadows AT
AU  - Byrne J
AU  - Haupt, R
AU  - Fears, T R
AU  - Robison, L L
AU  - Mills, J L
AU  - Nicholson, H S
AU  - Zeltzer, L K
AU  - Meadows, A T
AU  - Byrne, J
Y1  - 1994/11/09/
N1  - Accession Number: 107299984. Language: English. Entry Date: 19981201. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Challinor J, Karl D. Educational attainment in survivors of ALL. (JAMA) 10/11/95; 274 (14): 1134-1135. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: CPO-5625/CP/NCI NIH HHS/United States. NLM UID: 7501160. 
KW  - Leukemia, Lymphocytic -- Complications
KW  - Educational Status
KW  - Data Analysis, Statistical
KW  - Case Control Studies
KW  - Funding Source
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Male
KW  - Female
KW  - Human
SP  - 1427
EP  - 1432
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 272
IS  - 18
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To determine the impact of treatment on scholastic performance in the first cohort of survivors of childhood acute lymphoblastic leukemia who are old enough to have completed their educational experience.Design: Retrospective cohort study.Setting: Twenty-three institutions in the Childrens Cancer Group.Subjects: A total of 593 adult survivors of childhood acute lymphoblastic leukemia and 409 sibling controls.Outcome Measures: Enrollment in special programs, grades during high school, graduation from high school, college admission, and college graduation.Results: After diagnosis, survivors were more likely than their sibling controls to enter a special education (relative risk [RR] = 3.4; P < .01) or a learning disabled (RR = 3.6; P < .01) program, while just as likely to enter gifted and talented programs (RR = 1.0). The risk associated with special education and learning disabled programs increased with increasing dose of cranial radiotherapy. Despite these problems, survivors generally had the same probability as their siblings of finishing high school, entering college, and earning a bachelor's degree. However, survivors treated with 24 Gy and those diagnosed before 6 years of age were less likely to enter college (RR = 0.67 and 0.6, respectively; P < .01).Conclusions: This large study demonstrates that childhood acute lymphoblastic leukemia survivors have a greater likelihood of being placed in special education or learning disabled programs than their siblings, but that most are able to overcome these problems. Dose of cranial radiotherapy and age at diagnosis are the most important education-related risk factors.
SN  - 0098-7484
AD  - Clinical Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md
AD  - Dept Pediatric Hematology/Oncology, G Gaslini Children's Hosp, Largo G Gaslini 5, 16147 Genoa, Italy
U2  - PMID: 7933424.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Persson, Bengt
AU  - Zigler Jr., J. Samuel
AU  - Jörnvall, Hans
T1  - A super-family of medium-chain dehydrogenase/reductases (MDR).
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/11/15/
VL  - 226
IS  - 1
M3  - Article
SP  - 15
EP  - 22
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The protein super-family of medium-chain alcohol dehydrogenases (and glutathione-dependent formaldehyde dehydrogenase), polyol dehydrogenases, threonine dehydrogenase, archaeon glucose dehydrogenase, and eye lens reductase-active ζ-crystallins also includes Escherichia coli quinone oxidoreductase, Torpedo VAT-1 protein, and enoyl reductases of mammalian fatty acid and yeast erythronolide synthases. In addition, two proteins with hitherto unknown function are shown to belong to this super-family of medium-chain dehydrogenases and reductases (MDR). Alignment of ζ-crystallins/quinone oxidoreductases/VAT-1 reveals 38 strictly conserved residues, of which approximately half are glycine residues, including those at several space-restricted turn positions and critical coenzyme-binding positions in the alcohol dehydrogenases. This indicates a conserved three-dimensional structure at the corresponding parts of these distantly related proteins and a conserved binding of a coenzyme in the two proteins with hitherto unknown function, thus ascribing a likely oxidoreductase function to these proteins. When all forms are aligned, including enoyl reductases, a ζ-crystallin homologue from Leishmania and the two proteins with hitherto unknown function, only three residues are strictly conserved among the 106 proteins characterised within the super-family, and significantly these residues are all glycinees, corresponding to Gly66, Gly86 and Gly201 of mammalian class I alcohol dehydrogenase. Notably, these residues are located in different domans. Hence, a distant origin and divergent functions, but related forms and interactions, appear to apply to the entire chains of the many prokaryotic and eukaryotic members. Additionally, in the ζ-crystallins/quinone oxidoreductases, a highly conserved tyrosine residue is found. This residue, in the three-dimensional structure of the homologous alcohol dehydrogenase, is positioned at the sub-unit cleft that contains the active site and could therefore be involved in catalysis. If so, this residue and its role may resemble the pattern of a conserved tyrosine residue in the different family of short-chain dehydrogenases/reductases (SDR). [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOL dehydrogenase
KW  - DEHYDROGENASES
KW  - BIOSYNTHESIS
KW  - OXIDOREDUCTASES
KW  - QUINONE
KW  - PROTEINS
N1  - Accession Number: 13743735; Persson, Bengt 1,2 Zigler Jr., J. Samuel 3 Jörnvall, Hans 1; Affiliation:  1: Department of Medical Biochemistry and Biophysics,  Karolinska Institutet, Stockholm, Sweden  2: European Molecular Biology Laboratory, Heidelberg, Germany  3: Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, USA; Source Info: 11/15/94, Vol. 226 Issue 1, p15; Subject Term: ALCOHOL dehydrogenase; Subject Term: DEHYDROGENASES; Subject Term: BIOSYNTHESIS; Subject Term: OXIDOREDUCTASES; Subject Term: QUINONE; Subject Term: PROTEINS; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kiess, Wieland
AU  - Terry, Cheryl
AU  - Burgess, Wilson H.
AU  - Linder, Barbara
AU  - Lopaczynski, Wlodzimierz
AU  - Nissley, Peter
T1  - Insulin-like growth factor-II is a substrate for dipeptidylpeptidase I (cathepsin C).
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1994/11/15/
VL  - 226
IS  - 1
M3  - Article
SP  - 179
EP  - 184
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We observed that the lysosomal enzyme, dipeptidylaminopeptidase I (DAP-I) caused the release of trichloroacetic-acid-soluble radioactivity from rat 125I-insulin-like growth factor-II (IGF-II). This activity could be blocked by dipeptide inhibitors of DAP-I, and was enhanced by chloride. Treatment of unlabeled rat IGF-II with DAP-I converted approximately 50% of the IGF-II to a species with a slightly shorter elution time on reverse-phase HPLC, whereas treatment of human IGF-II caused complete conversion to the species with the shorter elution time. Rat IGF-II purified from the rat BRL 3A cell line is a mixture of two molecules beginning with Ala-Tyr-ARg-Pro-Ser- and Tyr-Arg-Pro-Ser- [Marquardt, H., Todaro, G.J., Henderson, L.E. & Oroszlan, S. (1981) J. Biol. Chem. 256, 6859-6865] while human IGF-II begins with Ala-Tyr-Arg-Pro-Ser-. Determination of the N-terminal amino acid sequence of human IGF-II before and after digestion with DAP-I showed that DAP-I-cleaved Ala-Tyr, terminating at Arg-Pro; the rat IGF-II species beginning with Tyr-Arg-Pro-Ser- was resistant to digestion. In order to compare DAP-I-treated IGF-II with native IGF-II for binding to IGF receptors and IGF-binding proteins and in a bioassay, rat and human IGF-II were treated with DAP-I and the digested and undigested species were isolated by reverse-phase HPLC. The IGF-II/mannose 6-phosphate receptor was purified from rat placental membranes, the IGF-I receptor was solubilized from human placental membranes and IGF-binding proteins were partially purified from adult and three-day-old rat sera by sequential gel filtration on Sephadex G-200 (pH 8.0) and Sephadex G-50 (acid pH). The dose/response curves of the two IGF-II species were indistinguishable in radioreceptor assays utilizing the IGF-II/mannose 6-phosphate receptor and the IGF-I receptor and in IGF competitive binding assays utilizing partially purified IGF-binding proteins. The DAP-I-digested and native IGF-II species were also equipotent in stimulating [³H]thymidine incorporation into DNA in the human osteosarcoma cell line, MG-63. We conclude that DAP-I cleaves an N-terminal dipeptide from IGF-II and that this does not result in a change in the biological activity of the molecule. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOMATOMEDIN
KW  - ENZYMES
KW  - LYSOSOMES
KW  - INSULIN
KW  - PEPTIDES
KW  - BIOCHEMISTRY
N1  - Accession Number: 13757508; Kiess, Wieland 1 Terry, Cheryl 1 Burgess, Wilson H. 2 Linder, Barbara 3 Lopaczynski, Wlodzimierz 1 Nissley, Peter 1; Affiliation:  1: Metabolism Branch, National Cancer Institute, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA  2: Jerome H. Holland Laboratory of the American Red Cross, Rockville, USA  3: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA; Source Info: 11/15/94, Vol. 226 Issue 1, p179; Subject Term: SOMATOMEDIN; Subject Term: ENZYMES; Subject Term: LYSOSOMES; Subject Term: INSULIN; Subject Term: PEPTIDES; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Steinert, Peter M.
AU  - North, Anthony C. T.
AU  - Parry, David A. D.
T1  - Structural Features of Keratin Intermediate Filaments.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/11/15/Nov94 Supplement
VL  - 103
M3  - Article
SP  - 19S
EP  - 24S
SN  - 0022202X
AB  - The first step in the assembly of a keratin intermediate filament (KIF) is the formation of a type I/type II heterodimer molecule in which two chains become aligned in parallel and close axial registration to form a flexible segmented α-helical coiled-coil rope 46 nm long. The segments of coiled-coil are interspersed by sequences that introduce irregularities of unknown structure. Here we have modeled two of these, the link L2 and the heptad discontinuity located near the middle of segment 2B. In a model for L2, the orientation of the coiled-coil structure is turned through about 180° over the eight residue stretch constituting this link segment. In contrast, the heptad discontinuity in segment 2B would seem to result in only minimal distortion of the coiled-coil rope, contrary to previous expectations. Little is known about how the neighboring molecules are aligned and packed within the assembled KIF. Crosslinking experiments with KIF have determined that two neighboring molecules are aligned antiparallel and axially in three ways, and predict that similarly-directed molecules could be overlapped by about 1 nm. The two-dimensional surface lattice resulting from these data predicts an axial periodicity of 22.6 nm, which in fact is visible by electron micros- copy of shadowed KIF. Interestingly, most of the amino acid substitutions resulting from mutations in the keratin genes found in genodermatoses are clustered in this molecular overlap region. Although we do not yet know how the rows of antiparallel molecules fold in three dimensions to form an intact KIF, certain of the observed crosslinks could also occur between nearest neighbor parallel molecules across a four-molecule strand; that is, KIF may be built from bundles or protofibrils. These insights on molecular structure and molecular packing provide new constraints on models for KIF structure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATIN
KW  - CYTOPLASMIC filaments
KW  - CROSSLINKING (Polymerization)
KW  - PROTEIN crosslinking
KW  - AMINO acids
KW  - MOLECULAR structure
KW  - ELECTRON microscopy
N1  - Accession Number: 12398900; Steinert, Peter M. 1 North, Anthony C. T. 2 Parry, David A. D. 3; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Department of Biochemistry and Molecular Biology, University of Leeds, Leeds, England.  3: Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand.; Source Info: Nov94 Supplement, Vol. 103, p19S; Subject Term: KERATIN; Subject Term: CYTOPLASMIC filaments; Subject Term: CROSSLINKING (Polymerization); Subject Term: PROTEIN crosslinking; Subject Term: AMINO acids; Subject Term: MOLECULAR structure; Subject Term: ELECTRON microscopy; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12398900
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yuspa, Stuart H.
AU  - Długosz, Andrzej A.
AU  - Cheng, Christina K.
AU  - Denning, Mitchell F.
AU  - Tennenbaum, Tamar
AU  - Glick, Adam B.
AU  - Weinberg, Wendy C.
T1  - Role of Oncogenes and Tumor Suppressor Genes in Multistage Carcinogenesis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/11/15/Nov94 Supplement
VL  - 103
M3  - Article
SP  - 90S
EP  - 95S
SN  - 0022202X
AB  - The introduction of the techniques of molecular biology as tools to study skin carcinogenesis has provided more precise localization of biochemical pathways that regulate the tumor phenotype. This approach has identified genetic changes that are characteristic of each of the specific stages of squamous cancer pathogenesis: initiation, exogenous promotion, premalignant progression, and malignant conversion. Initiation can result from mutations in a single gene, and the Harvey allele of the ras gene family has been identified as a frequent site for initiating mutations. Heterozygous activating mutations in <em>c-ras</em>Ha are dominant, and affected keratinocytes hyperproliferate and are resistant to signals for terminal differentiation. An important pathway impacted by <em>c-ras</em>Ha activation is the protein kinase C (PKC) pathway, a major regulator of keratinocyte differentiation. Increased activity of PKCα and suppression of PKCδ by tyrosine phosphorylation contribute to the phenotypic consequences of <em>ras</em>Ha gene activation in keratinocytes. Tumor promoters disturb epidermal homeostasis and cause selective clonal expansion of initiated cells to produce multiple benign squamous papillomas. Resistance to differentiation and enhanced growth rate of initiated cells impart a growth advantage when the epidermis is exposed to promoters. The frequency of premalignant progression varies among papillomas, and subpopulations at high risk for progression have been identified. These high-risk papillomas overexpress the α6β4 integrin and are deficient in transforming growth factor β1 and β2 peptides, two changes associated with a very high proliferation rate in this subset of tumors. The introduction of an oncogenic <em>ras</em>Ha gene into epidermal cells derived from transgenic mice with a null mutation in the TGFβ1 gene have an accelerated rate of malignant progression when examined <em>in vivo</em>. Thus members of the TGFβ gene family contribute a tumor-suppressor function in carcinogenesis.  Accelerated malignant progression is also found with <em>v-ras</em>Ha transduced keratinocytes from skin of mice with a null mutation in the p53 gene.  The similarities in risk for malignant conversion by initiated keratinocytes from TGFβ and p53 null geneotypes suggest that a common, growth-related pathway may underly the tumor-suppressive functions of these proteins in the skin carcinogenesis model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARCINOGENESIS
KW  - ANTIONCOGENES
KW  - CANCER genetics
KW  - PHENOTYPE
KW  - MUTATION (Biology)
KW  - KERATINOCYTES
KW  - MOLECULAR biology
N1  - Accession Number: 12399255; Yuspa, Stuart H. 1 Długosz, Andrzej A. 1 Cheng, Christina K. 1 Denning, Mitchell F. 1 Tennenbaum, Tamar 1 Glick, Adam B. 1 Weinberg, Wendy C. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland U.S.A.; Source Info: Nov94 Supplement, Vol. 103, p90S; Subject Term: CARCINOGENESIS; Subject Term: ANTIONCOGENES; Subject Term: CANCER genetics; Subject Term: PHENOTYPE; Subject Term: MUTATION (Biology); Subject Term: KERATINOCYTES; Subject Term: MOLECULAR biology; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12399255
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kraemer, Kenneth H.
AU  - Levy, Dan D.
AU  - Parris, Christopher N.
AU  - Gozukara, Engin M.
AU  - Moriwaki, Shinichi
AU  - Adelberg, Steven
AU  - Seidman, Michael M.
T1  - Xeroderma Pigmentosum and Related Disorders: Examining the Linkage Between Defective DNA Repair and Cancer.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/11/15/Nov94 Supplement
VL  - 103
M3  - Article
SP  - 96S
EP  - 101S
SN  - 0022202X
AB  - Xeroderma pigmentosum, Cockayne syndrome, the xeroderma pigmentosum - Cockayne syndrome complex, and trichothiodystrophy cells have defects in DNA repair and are associated with clinical and cellular hypersensitivity to ultraviolet radiation (UV). Familial dysplastic nevus syndrome cells have UV hyper-mutability. Although xeroderma pigmentosum and dysplastic nevus syndrome have markedly increased cancer risk, Cockayne syndrome and trichothiodystrophy do not. At the molecular level, these disorders are associated with several different genetic defects as evidenced by the existence of multiple overlapping complementation groups. Recent progress has been made in identifying the chromosomal location and cloning the defective genes in these disorders. Using plasmid shuttle vectors we have shown abnormal repair and mutagenesis of DNA damaged by 254-nm (UVC) or 295-nm (UVB) radiation or the chemical carcinogen aflatoxin in cells from patients with xeroderma pigmentosum. Although xeroderma pigmentosum cells are defective in repair of all photoproducts, Cockayne syndrome cells appear to be defective in repair of cyclobutane dimers and have normal repair of nondimer photoproducts. DNS cells have post UV plasmid hypermutability. These diseases may serve as models for examining molecular mechanisms of carcinogenesis in humans. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - XERODERMA pigmentosum
KW  - SKIN abnormalities
KW  - CANCER
KW  - DNA repair
KW  - ALLERGY
KW  - ULTRAVIOLET radiation
KW  - MUTATION (Biology)
KW  - <em>Cockayne syndrome</em>
KW  - <em>complementation groups</em>
KW  - <em>dysplastic nevus syndrome</em>
KW  - <em>trichothiodystrophy</em>
N1  - Accession Number: 12399329; Kraemer, Kenneth H. 1 Levy, Dan D. 1 Parris, Christopher N. 1 Gozukara, Engin M. 1 Moriwaki, Shinichi 1 Adelberg, Steven 1 Seidman, Michael M. 2; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland.  2: Otsuka Pharmaceuticals, Rockville, Maryland, U.S.A.; Source Info: Nov94 Supplement, Vol. 103, p96S; Subject Term: XERODERMA pigmentosum; Subject Term: SKIN abnormalities; Subject Term: CANCER; Subject Term: DNA repair; Subject Term: ALLERGY; Subject Term: ULTRAVIOLET radiation; Subject Term: MUTATION (Biology); Author-Supplied Keyword: <em>Cockayne syndrome</em>; Author-Supplied Keyword: <em>complementation groups</em>; Author-Supplied Keyword: <em>dysplastic nevus syndrome</em>; Author-Supplied Keyword: <em>trichothiodystrophy</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12399329
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hetherington, Marion M.
AU  - Altemus, Margaret
AU  - Nelson, Mark L.
AU  - Bernat, Aviva S.
AU  - Gold, Philip W.
T1  - Eating behavior in bulimia nervosa: multiple meal analyses.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/12//
VL  - 60
IS  - 6
M3  - Article
SP  - 864
EP  - 873
SN  - 00029165
AB  - Ten bulimic individuals were admitted to an inpatient unit and for 7 consecutive days eating behavior was observed and recorded. Age, sex, and weight-matched control subjects (n = 10) were admitted to the same unit for 4 d. All food and fluid intake, frequency of binge eating and purging, and ratings of appetite and mood before and after eating were recorded every 24 h. Bulimic patients demonstrated chaotic eating patterns that varied within as well as between individuals. Total daily energy intake was significantly higher for bulimic patients (41982 ± 113 kJ; 10 034 ± 2701 kcal) than for control subjects (8050 ± 0427 kJ; 1924 ± 102 kcal). On average, patients binged 1.6 times, purged three times, and ate one snack or meal without purging daily. Macronutnient analyses of intake revealed significantly less energy from protein and more energy from fat in bulimic patients compared with control subjects. Some improvement of mood was noted after binges, the magnitude of which was greatest after purging. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Eating disorders -- Psychological aspects
KW  - Eating disorders -- Physiological aspects
KW  - Affective disorders
KW  - Mood (Psychology) -- Physiological aspects
KW  - Bulimia
KW  - TREATMENT
KW  - Appetite -- Physiological aspects
KW  - Appetite -- Psychological aspects
KW  - appetite
KW  - bulimia nervosa
KW  - Eating behavior
KW  - eating disorders
KW  - mood
N1  - Accession Number: 94426480; Hetherington, Marion M. 1; Altemus, Margaret 1; Nelson, Mark L. 1; Bernat, Aviva S. 1; Gold, Philip W. 1; Affiliations: 1: Clinical Neuroendocninology Branch, National Institute of Mental Health, NIH, Bethesda, MD; Issue Info: Dec1994, Vol. 60 Issue 6, p864; Thesaurus Term: RESEARCH; Subject Term: Eating disorders -- Psychological aspects; Subject Term: Eating disorders -- Physiological aspects; Subject Term: Affective disorders; Subject Term: Mood (Psychology) -- Physiological aspects; Subject Term: Bulimia; Subject Term: TREATMENT; Subject Term: Appetite -- Physiological aspects; Subject Term: Appetite -- Psychological aspects; Author-Supplied Keyword: appetite; Author-Supplied Keyword: bulimia nervosa; Author-Supplied Keyword: Eating behavior; Author-Supplied Keyword: eating disorders; Author-Supplied Keyword: mood; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Osmond, Dennis H.
AU  - Page, Kimberly
AU  - Wiley, James
AU  - Garrett, Karen
AU  - Sheppard, Haynes W.
AU  - Moss, Andrew R.
AU  - Schrager, Lewis
AU  - Winkelstein, Warren
T1  - HIV Infection in Homosexual and Bisexual Men 18 to 29 Years of Age: The San Francisco Young Men's Health Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/12//
VL  - 84
IS  - 12
M3  - Article
SP  - 1933
EP  - 1937
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Recent studies suggest very high human immunodeficiency virus (HIV) infection rates in some populations of younger homosexual men, but these studies may represent only particularly high-risk populations. The current study obtained population-based data on the HIV epidemic in young homosexual/bisexual men. Methods. A household survey of unmarried men 18 through 29 years of age involved a multistage probability sample of addresses in San Francisco. A follow-up interview and HIV test for men who were HIV negative at baseline were completed; the median follow-up was 8.9 months. Results. Sixty-eighty of 380 homosexual/bisexual men (17.9%) tested HIV seropositive. Sixty-three percent of men reported one or more receptive anal intercourse partners in the previous 12 months, and 41% of those men did not sue condoms consistently. The HIV seroincidence rate among those seronegative at first study was 2.6% per year. Conclusions. HIV infection rates in young homosexual men in San Francisco are lower those in the early 1930; however, the rate of infection in these men, most of whom became sexually active after awareness of AIDS had become wide-spread, threatens to continue the epidemic in the younger generation at a level not far below that of a decade ago. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV infections
KW  - GAY men -- Health
KW  - BISEXUAL men
KW  - MEN -- Sexual behavior
KW  - YOUNG men -- United States
KW  - SAN Francisco (Calif.)
KW  - CALIFORNIA
N1  - Accession Number: 9501191604; Osmond, Dennis H. 1 Page, Kimberly 2 Wiley, James 3 Garrett, Karen 3 Sheppard, Haynes W. 4 Moss, Andrew R. 1 Schrager, Lewis 5 Winkelstein, Warren 2; Affiliation:  1: Division of Epidemiology and Medicine, San Francisco General Hospital, University of California, San Francisco Medical Center  2: School of Public Health, Division of Epidemiology and Population Biology, University of California, Berkeley  3: Survey Research Center, University of California, Berkeley  4: California Department of Health Services, Berkeley  5: National Institute of Allergy and Infectious Diseases, Bethesda, Md.; Source Info: Dec1994, Vol. 84 Issue 12, p1933; Subject Term: HIV infections; Subject Term: GAY men -- Health; Subject Term: BISEXUAL men; Subject Term: MEN -- Sexual behavior; Subject Term: YOUNG men -- United States; Subject Term: SAN Francisco (Calif.); Subject Term: CALIFORNIA; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Limanonda, Bhassorn
AU  - Van Griensven, Godfried J. P.
AU  - Chongvatana, Noppavan
AU  - Tirasawat, Penporn
AU  - Coutinho, Roel A.
AU  - Auwanit, Wattana
AU  - Nartpratarn, Chavalit
AU  - Likhityingvara, Chuvit
AU  - Poshyachinda, Vichai
T1  - Condom Use and Risk Factors for HIV-1 Infection among Female Commercial Sex Workers in Thailand.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1994/12//
VL  - 84
IS  - 12
M3  - Letter
SP  - 2026
EP  - 2027
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented about the prevalence of HIV-1 infection among female commercial sex workers in Chiangmai City and Sungaikolok District in Thailand.
KW  - LETTERS to the editor
KW  - HIV infections
N1  - Accession Number: 20696775; Limanonda, Bhassorn 1 Van Griensven, Godfried J. P. 2 Chongvatana, Noppavan 1 Tirasawat, Penporn 1 Coutinho, Roel A. 2 Auwanit, Wattana 3 Nartpratarn, Chavalit 4 Likhityingvara, Chuvit 5 Poshyachinda, Vichai 1; Affiliation:  1: Chulalongkorn University, Bangkok, Thailand  2: Department of Public Health, Amsterdam, the Netherlands  3: Thai National Institutes of Health, Bangkok, Thailand  4: Thai Centers for Disease Control, Chiangmai, Thailand  5: Provincial Public Health Office, Narathiwat, Thailand; Source Info: Dec1994, Vol. 84 Issue 12, p2026; Subject Term: LETTERS to the editor; Subject Term: HIV infections; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107425174
T1  - Rehabilitation of people with severe mental disorders: lessons from healthcare reform.
AU  - Kennedy C
Y1  - 1994///Winter94/95
N1  - Accession Number: 107425174. Language: English. Entry Date: 19951101. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7610370. 
KW  - Rehabilitation, Psychosocial -- Legislation and Jurisprudence -- United States
KW  - Mental Disorders -- Rehabilitation
KW  - Activities of Daily Living
KW  - Health Care Reform
KW  - United States
SP  - 29
EP  - 32
JO  - American Rehabilitation
JF  - American Rehabilitation
JA  - AM REHABIL
VL  - 20
IS  - 4
CY  - Washington, District of Columbia
PB  - US Government Printing Office
AB  - The specific inclusion of rehabilitation as a covered service under long-term care benefits in recent federal healthcare reform bills served to endorse rehabilitation as a necessary component of an integrated healthcare system. It also highlighted both the similarities and uniqueness of disabilities, thus the need for an array of services for people with severe physical and mental disorders. These similarities and distinctions also required thoughtful planning for implementation in terms of equivalent eligibility criteria for long-term care benefits for people severely disabled by their disorders. While no federal health reform bill was enacted, the issues raised continue to have impact on thought and planning for healthcare services. One example of this impact is the recent proposal to reconfigure the state service system for people with severe mental disorders on Medicaid in rehabilitation-oriented New York State (Foderaro, 1994).
SN  - 0362-4048
AD  - Division of Epidemiology and Service Research, National Institute of Mental Health, Rockville, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hoelzel, A. Rus
T1  - GENETICS AND ECOLOGY OF WHALES AND DOLPHINS.
JO  - Annual Review of Ecology & Systematics
JF  - Annual Review of Ecology & Systematics
Y1  - 1994/12//
VL  - 25
M3  - Article
SP  - 377
EP  - 399
PB  - Annual Reviews Inc.
SN  - 00664162
AB  - Cetacean species are widely distributed in the world's oceans, and their populations are impacted by human activity both directly through hunting and indirectly. The determination of genetic stock boundaries and genetic diversity within stocks is essential to the conservation of genetic diversity in these as in any other species, but cetaceans present special challenges. The definition of stock boundaries based on assumptions drawn from experience with terrestrial species has proven inadequate for cetaceans. For example, genetic stock boundaries do not necessarily correspond to patterns of apparent geographic isolation. Cetaceans are capable of migrating great distances, and in some cases breeding populations mix in seasonal feeding grounds up to thousands of miles from where they breed. Among those species that breed and forage within the same geographic range, intraspecific differences in feeding ecology can lead to the genetic differentiation of local populations. This review presents a summary of the available data on genetic diversity and differentiation within cetacean species, with an emphasis on the ecological context. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annual Review of Ecology & Systematics is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CETACEA
KW  - SPECIES
KW  - MARINE mammals
KW  - POPULATION genetics
KW  - MOLECULAR genetics
KW  - HUNTING
KW  - ANIMAL nutrition
KW  - ECOLOGY
KW  - OCEAN
KW  - cetaceans
KW  - marine mammals
KW  - molecular genetics
KW  - population genetics
N1  - Accession Number: 11913897; Hoelzel, A. Rus 1; Affiliation:  1: Laboratory of Viral Carcinogenesis, Building 560, National Cancer Institute, Frederick, Maryland, 21702.; Source Info: 1994, Vol. 25, p377; Subject Term: CETACEA; Subject Term: SPECIES; Subject Term: MARINE mammals; Subject Term: POPULATION genetics; Subject Term: MOLECULAR genetics; Subject Term: HUNTING; Subject Term: ANIMAL nutrition; Subject Term: ECOLOGY; Subject Term: OCEAN; Author-Supplied Keyword: cetaceans; Author-Supplied Keyword: marine mammals; Author-Supplied Keyword: molecular genetics; Author-Supplied Keyword: population genetics; NAICS/Industry Codes: 114210 Hunting and Trapping; Number of Pages: 23p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Alex, S.;
AU  - Gupta, S.;
AU  - Minor, J. R.;
AU  - Gallelli, J.;
AU  - Piscitelli, S. C.;
T1  - Evaluation of three methods for assessing compatibility of interleukin-2 (Aldesleukin) with antiemetics and AIDS-related drugs during simulated Y-site administration
CT  - Evaluation of three methods for assessing compatibility of interleukin-2 (Aldesleukin) with antiemetics and AIDS-related drugs during simulated Y-site administration
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1994/12/01/
VL  - 29
IS  - Dec
SP  - P
EP  - )
AD  - Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 31-12060; Language: English; Chemical Name: Interleukin 2--102524-44-7; Publication Type: Abstract of Meeting Presentation; Section Heading: Drug Analysis; Drug Stability
N2  - Compatibility of interleukin-2 (IL-2), a promising immunotherapeutic agent being evaluated in patients with HIV infection, was examined with nineteen secondary parenteral drugs during simulated Y-site administration in 1:1 ratio. IL-2 was prepared at a concentration of 0.0338 million IU/ml and secondary drugs were prepared according to concentrations used in routine clinical practice. The study consisted of 3 phases: visual inspection, spectrophotometry and bioassay. All drugs studied except lorazepam were found to be physically compatible with IL-2. However, testing by bioassay revealed that lorazepam, foscarnet, ganciclovir and dopamine reduced the biological activity of IL-2. Five drugs were toxic to the bioassay cell line and could not be evaluated. Visual inspection and spectrophotometry are not reliable methods for compatibility testing of proteinaceous drugs.
KW  - Interleukin 2--stability-;
KW  - Practice Interest Areas--Intravenous Therapy/Infusion Devices--meeting presentations;
KW  - ASHP meeting abstracts--interleukin 2, incompatibilities;
KW  - Stability--interleukin 2--incompatibilities, antiemetics;
KW  - Incompatibilities--interleukin 2--stability;
KW  - Injections--interleukin 2--incompatibilities;
KW  - Anti-emetics--stability--injections, interleukin 2;
KW  - Tests--spectrometry--compatibility, interleukin 2;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Macklin, L. R.;
AU  - Pucino, F.;
AU  - Goad, K. E.;
AU  - Yarboro, C.;
AU  - Klippel, J. H.;
T1  - Niacin-induced changes in L\LC/p\UC/(\LC/a\UC/) on fibrinolytic parameters in hyperlipidemic lupus (SLE)/membranous nephropathy (MN) patients
CT  - Niacin-induced changes in L\LC/p\UC/(\LC/a\UC/) on fibrinolytic parameters in hyperlipidemic lupus (SLE)/membranous nephropathy (MN) patients
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1994/12/01/
VL  - 29
IS  - Dec
SP  - P
EP  - )
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Pharmacy Dept., Bldg. 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 31-11920; Language: English; Chemical Name: Niacin--59-67-6; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2  - Elevated Lp(a) concentrations are associated with coronary artery disease (CAD) and thrombotic events, conditions common to SLE and MN patients. Niacin reduces Lp(a) by 38-45 percent. This open-label, parallel-design pilot trial will evaluate the effects of niacin-induced changes in cholesterol and Lp(a) on hemostatic parameters. A total of 30 hyperlipidemic patients (15 with Lp(a) \LE/25 mg/dL and 15 with Lp(a) \GE/45 mg/dL) who have SLE and/or MN will be recruited. Following a 4-week niacin titration, patients will receive niacin 3 g/day for 6 weeks. Twenty-three hemostatic parameters will be assessed at weeks 0, 2, 4, 7, and 10 of therapy. Niacin will then be discontinued and parameters reassessed in 6 weeks.
KW  - Niacin--effects-;
KW  - Practice Interest Areas--Ambulatory Care/Community Practice--meeting presentations;
KW  - ASHP meeting abstracts--niacin, fibrinolytic parameters;
KW  - Glomerulonephritis--niacin--membranous, fibrinolytic parameters;
KW  - Hyperlipidemia--niacin--fibrinolytic parameters;
KW  - Lupus erythematosus--niacin--systemic, fibrinolytic parameters;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Baltz, J. K.;
T1  - Antitumor vaccines
CT  - Antitumor vaccines
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1994/12/01/
VL  - 29
IS  - Dec
SP  - SPG
EP  - -33
AD  - National Cancer Institute, EPN 804, 6130 Executive Blvd MSC 7442, Bethesda, MD 20892-7442, USA
N1  - Accession Number: 31-12000; Language: English; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - Although progress has been made in the treatment of some early stage cancers, new methods of treatment are still needed for more effective therapy of advanced malignant diseases. At this point in time, clinical trials are under way utilizing repeated vaccinations with a recombinant virus containing a specific antigen gene. Background information will include a review of how the immune system functions in response to vaccinations as well as the advantages and disadvantages of using this method of treatment for cancer. Desirable characteristics of viral vectors used in vaccinations will be described and examples of vaccines will be given. Examples will include the vaccinia virus vaccine which in one trial contains the human carcinoembryonic antigen gene (rV-CEA) and in another, the human prostate-specific antigen gene (rV-PSA). An update of select clinical trials will be given with emphasis on toxicities, tumor responses and humoral and cellular immunity endpoints, which are usuall the objectives of these early trials. Learning objectives: 1. Briefly outline the historical development of the use of vaccines to treat cancer. 2. Describe the difference between tumor vaccines and the use of monoclonal antibodies in the treatment of cancer. 3. Discuss the advantages and disadvantages of using vaccinia virus as a vector for tumor associated antigens. Self-assessment questions: 1. Tumor vaccines express a tumor-specific antigen to produce an immune response in the patient's body. 2. Monoclonal antibodies differ from vaccines in that they are employed to deliver radioactive moieties or other toxins to cells which express the antigen, rather than inducing an immunologic response. 3. Vaccine vectors should be chosen based on genetic stability, established means of storage, transport, and delivery. Answers: 1. (T), 2. (T), 3. (T).
KW  - Neoplasm vaccines--immunization-;
KW  - ASHP meeting abstracts--neoplasm vaccines;
KW  - Immunization--neoplasms--vaccines, clinical studies;
KW  - Clinical studies--neoplasm vaccines--immunization;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - The Stability of Personality: Observations and Evaluations.
JO  - Current Directions in Psychological Science
JF  - Current Directions in Psychological Science
Y1  - 1994/12//
VL  - 3
IS  - 6
M3  - Article
SP  - 173
EP  - 175
PB  - Sage Publications Inc.
SN  - 09637214
AB  - The article analyses Ralph Waldo Emerson's theory of the stability of personality. Emerson anticipated modern findings about the stability of personality and pointed out an illusion to which both laypersons and psychologists are prone. He was also perhaps first to decry personality stability as the enemy of freedom, creativity and growth, objecting that "temperament puts all divinity to rout." Emerson used the term temperament to refer to the basic tendencies of the individual, dispositions that are called personality traits. It is these traits, measured by such instruments as the Minnesota Multiplastic Personality Inventory, that have been investigated in a score of longitudinal studies over the past 20 years. The general conclusion that personality traits are stable is now widely is now widely accepted. Some researchers continue to look for change in special circumstances and populations, some attempt to account for stability by examining genetic and environmental influences on personality.
KW  - PERSONALITY
KW  - INVENTORIES
KW  - PERSONALITY tests
KW  - POPULATION
KW  - SOCIAL science research
KW  - EMERSON, Ralph Waldo, 1803-1882
N1  - Accession Number: 10770693; McCrae, Robert R. 1 Costa Jr., Paul T. 2; Affiliation:  1: Research Psychologist, Gerontology Research Center, National Institute of Aging, National Institutes of Health  2: Chief, Laboratory of Personality and Cognition, Gerontology Research Center, National Institute of Aging, National Institutes of Health; Source Info: Dec94, Vol. 3 Issue 6, p173; Subject Term: PERSONALITY; Subject Term: INVENTORIES; Subject Term: PERSONALITY tests; Subject Term: POPULATION; Subject Term: SOCIAL science research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; People: EMERSON, Ralph Waldo, 1803-1882; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1467-8721.ep10770693
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nappi, Antonio
AU  - Cuocolo, Alberto
AU  - Iazzetta, Nicolangelo
AU  - Ferrara, L.
AU  - Marotta, Teodoro
AU  - Pace, Leonardo
AU  - Nicolai, Emanuele
AU  - Michele, Giuseppe
AU  - Campanella, Giuseppe
AU  - Salvatore, Marco
AU  - Postiglione, Alfredo
T1  - Ambulatory monitoring of left ventricular function in patients with Parkinson's disease and postural hypotension.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1994/12//
VL  - 21
IS  - 12
M3  - Article
SP  - 1312
EP  - 1317
SN  - 03406997
N1  - Accession Number: 71146451; Nappi, Antonio 1 Cuocolo, Alberto 1 Iazzetta, Nicolangelo 2 Ferrara, L. 2 Marotta, Teodoro 2 Pace, Leonardo 1 Nicolai, Emanuele 1 Michele, Giuseppe 3 Campanella, Giuseppe 3 Salvatore, Marco 2 Postiglione, Alfredo 4; Affiliation:  1: Department of Nuclear Medicine, University 'Federico II', Naples Italy  2: Institute of Internal Medicine and Metabolic Diseases, University 'Federico II', Naples Italy  3: Institute of Neurological Sciences, University 'Federico II', Naples Italy  4: National Cancer Institute, Naples Italy; Source Info: Dec1994, Vol. 21 Issue 12, p1312; Number of Pages: 6p; Document Type: Article
L3  - 10.1007/BF02426695
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Maffioli, Lorenzo
AU  - Chiti, Arturo
AU  - Gasparini, Massimo
AU  - Bombardieri, Emilio
T1  - Sensitivity versus specificity in melanoma imaging using iodine-123 iodobenzamide and indium-111 pentetreotide [1].
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1994/12//
VL  - 21
IS  - 12
M3  - Letter
SP  - 1366
EP  - 1366
SN  - 03406997
N1  - Accession Number: 71146444; Maffioli, Lorenzo 1 Chiti, Arturo 1 Gasparini, Massimo 1 Bombardieri, Emilio 1; Affiliation:  1: National Cancer Institute Nuclear Medicine Division, Via Venezian 1 1-20133 Milan Italy; Source Info: Dec1994, Vol. 21 Issue 12, p1366; Number of Pages: 1p; Document Type: Letter
L3  - 10.1007/BF02426702
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107417829
T1  - Mononuclear cell adoptive immunotherapy.
AU  - Lee J
AU  - Klein HG
Y1  - 1994/12//1994 Dec
N1  - Accession Number: 107417829. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8709473. 
KW  - Immunotherapy
KW  - Blood Component Transfusion
KW  - Lymphocytes
KW  - Monocytes
SP  - 1203
EP  - 1221
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
JA  - HEMATOL ONCOL CLIN NORTH AM
VL  - 8
IS  - 6
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0889-8588
AD  - Department of Transfusion Medicine, Building 10, Room 1C-711, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 7860445.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Mandy, S.
AU  - Feng, Z.
AU  - Canfield, L.S.
AU  - Mandy, K.
AU  - Quan, X.
AU  - Rowehl, R. A.
AU  - Khan, M. Y.
AU  - Akiyama, S. K.
AU  - Godfrey, H. P.
T1  - Inhibition of expression of delayed hypersensitivity by neutralizing monoclonal anti-T-cell fibronectin antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1994/12//
VL  - 83
IS  - 4
M3  - Article
SP  - 582
EP  - 588
PB  - Wiley-Blackwell
SN  - 00192805
AB  - T-cell fibronectin (FN) is a unique cellular FN that is rapidly synthesized by memory T cells in response to antigen. Monoclonal anti-T-cell FN antibodies have been used to clarify the role of T-cell FN in the in vivo expression of delayed hypersensitivity. IgG1(κ) mouse anti-human T-cell FN monoclonal antibodies 231 and 248 recognized epitopes on the FN cell-binding domain, were cross-reactive with plasma FN, and neutralized human and guinea-pig T-cell FN monocyte agglutinating activity. When injected intradermally together with tuberculin or 30 min before topical application of reactive sensitizer, antibody 231 significantly decreased macroscopic expression of guinea-pig delayed hypersensitivity at 24 hr in a dog-dependent manner. Similar doses of antibody 248 caused a slight statistically non-significant enhancement of delayed-type hypersensitivity (DTH) expression. Inhibition of visible skin responses was not associated with qualitative or quantitative changes in cellular infiltrates at the reaction site. Antibody 231 modulated expression of delayed hypersensitivity in a qualitatively and quantitatively similar manner to the FN-binding mycobacterial antigen 85 proteins. This is consistent with anti-T-cell FN and antigen 85 acting on the same molecule in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCLONAL antibodies
KW  - IMMUNOGLOBULINS
KW  - T cells
KW  - FIBRONECTINS
KW  - DELAYED hypersensitivity
KW  - IMMUNOLOGY
N1  - Accession Number: 13363224; Mandy, S. Feng, Z. Canfield, L.S. Mandy, K. 1 Quan, X. 1 Rowehl, R. A. 2 Khan, M. Y. 3 Akiyama, S. K. 4 Godfrey, H. P. 1; Affiliation:  1: Departments of Experimental Pathology, New York Medical College, Valhalla, New York  2: Department of Microbiology, State University of New York at Stony Brook, Stony Brook, New York  3: Cell Biology and Anatomy, New York Medical College, Valhalla, New York  4: Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Dec94, Vol. 83 Issue 4, p582; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: T cells; Subject Term: FIBRONECTINS; Subject Term: DELAYED hypersensitivity; Subject Term: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107391475
T1  - Case management for substance abusers: more issues than answers.
AU  - Ashery RS
Y1  - 1994///1994 Winter
N1  - Accession Number: 107391475. Language: English. Entry Date: 19961201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9301156. 
KW  - Case Management
KW  - Substance Abusers
KW  - Goals and Objectives
KW  - Outcomes (Health Care)
KW  - Workload
SP  - 179
EP  - 183
JO  - Journal of Case Management
JF  - Journal of Case Management
JA  - J CASE MANAGE
VL  - 3
IS  - 4
CY  - New York, New York
PB  - Springer Publishing Company, Inc.
AB  - Although case management has been successfully used in medical settings, its use for the delivery of multiple services for the substance abuser is questioned. An overview of the research suggests that low client-to-worker ratios, frequent and intense contacts, and chronic client relapse often contradict the emphasis on cost-containment, cost-effectiveness, and 'successful' outcomes. The implementation of case management programs for substance abusers should proceed with caution. More emphasis should be placed on a community systems advocacy approach.
SN  - 1061-3706
AD  - National Institute on Drug Abuse, Prevention Research Branch, 5600 Fishers Lane, Room 9A-53, Rockville, MD 20857
U2  - PMID: 7735091.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kimonis, Virginia
AU  - DiGiovanna, John J.
AU  - Jun-Mo Yang
AU  - Doyle, Sharon Z.
AU  - Bale, Sherri J.
AU  - Compton, John G.
T1  - A Mutation in the V1 End Domain of Keratin 1 in Non-Epidermolytic Palmar-Plantar Keratoderma.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1994/12//
VL  - 103
IS  - 6
M3  - Article
SP  - 764
EP  - 769
SN  - 0022202X
AB  - Mutations in keratin 9 have been found in families with an epidermolytic form of palmar-plantar keratoderma (PPK). In another form of PPK (Unna-Thost type), epidermolysis is not observed histologically. We studied a pedigree with this non-epidermolytic form of PPK. By gene linkage analysis, the type I keratin locus could be excluded but complete linkage with the type II keratin region was found. Sequence analysis identified a single base change in the amino-terminal V1 variable subdomain of keratin 1, which caused a lysine to isoleucine substitution. This non-conservative mutation completely cosegregated with the disease and was not observed in 50 unrelated unaffected individuals. An examination of keratin amino-terminal sequences revealed a previously unreported 22-residue window in the V1 subdomain that is conserved among most type II keratins. The altered lysine is an invariant residue in this conserved sequence. Previously described keratin mutations affect the central regions important for filament assembly and stability, and cause diseases characterized by cellular degeneration or disruption. This is the first disease mutation in a keratin chain variable end region. The observation that it is not associated with epidermolysis supports the concept that the amino-terminal domain of keratins may be involved in supramolecular interactions of keratin filaments rather than stability. Therefore, hyperkeratosis associated with this mutation may be due to perturbations in the interactions of the keratin end domain with other cellular components. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MUTATION (Biology)
KW  - KERATIN
KW  - GENES
KW  - HISTOLOGY
KW  - LYSINE
KW  - DEGENERATION
N1  - Accession Number: 12412771; Kimonis, Virginia 1 DiGiovanna, John J. 2 Jun-Mo Yang 1 Doyle, Sharon Z. 1 Bale, Sherri J. 1 Compton, John G. 1; Affiliation:  1: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec94, Vol. 103 Issue 6, p764; Subject Term: MUTATION (Biology); Subject Term: KERATIN; Subject Term: GENES; Subject Term: HISTOLOGY; Subject Term: LYSINE; Subject Term: DEGENERATION; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12412771
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hunsberger, Sally
T1  - Semiparametric Regression in Likelihood-Based Models.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1994/12//
VL  - 89
IS  - 428
M3  - Article
SP  - 1354
EP  - 1365
SN  - 01621459
AB  - A weighted likelihood is used to estimate the parameters in a semiparametric model involving two covariates and allowing an association between the covariates The development is for arbitrary but specified densities of the observations The estimators are consistent and asymptotically normal Hypothesis testing of the parametric component can be performed using a Wald test Simulations and analysis of data with Bernoulli observations demonstrate the estimators' application Speckman developed kernel estimators where the conditional density of the observations is normal with p parametric covariates Speckman's estimators and the new estimators are asymptotically equivalent, with the bias of Speckman's estimators being smaller As an example, we study the relationship between a binary response indicating the occurrence of an intraoperative cardiac complication (ICC) in vascular surgery patients and two risk factors duration of the operation (OR) and ASA score, which is an evaluation of the patient's overall health prior to surgery ASA score is modeled in the parametric portion, because it appears valid to assume that ASA is linearly related to the logit of the probability of an ICC The functional relationship between OR duration and the logit of the probability of an ICC is unknown, so a is modeled non parametrically. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MATHEMATICAL models
KW  - STATISTICAL hypothesis testing
KW  - MATHEMATICS
KW  - REGRESSION analysis
KW  - MATHEMATICAL statistics
KW  - PARAMETER estimation
KW  - ESTIMATION theory
KW  - BERNOULLI hypothesis (Risk)
KW  - STOCHASTIC processes
KW  - Kernel smoothers
KW  - Partial linear model
KW  - Weighted likelihood
KW  - Weighted likelihood.
N1  - Accession Number: 9501111701; Hunsberger, Sally 1; Affiliations: 1: Mathematical Statistician, Biostatistics Research Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.; Issue Info: Dec94, Vol. 89 Issue 428, p1354; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MATHEMATICS; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PARAMETER estimation; Thesaurus Term: ESTIMATION theory; Thesaurus Term: BERNOULLI hypothesis (Risk); Thesaurus Term: STOCHASTIC processes; Author-Supplied Keyword: Kernel smoothers; Author-Supplied Keyword: Partial linear model; Author-Supplied Keyword: Weighted likelihood; Author-Supplied Keyword: Weighted likelihood.; Number of Pages: 12p; Illustrations: 4 Charts, 9 Graphs; Document Type: Article; Full Text Word Count: 8454
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107411015
T1  - Plasma estradiol in premenopausal women: the Framingham Offspring Study.
AU  - Garrison RJ
AU  - Sawin CT
AU  - Alexander LL
AU  - Wilson PWF
Y1  - 1994/12//1994 Dec
N1  - Accession Number: 107411015. Language: English. Entry Date: 19950701. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Estradiol -- Analysis
KW  - Premenopause
KW  - Lipoproteins -- Analysis
KW  - Coronary Disease
KW  - Questionnaires
KW  - Adipose Tissue
KW  - Reproductive History
KW  - Regression
KW  - Exercise Test, Cardiopulmonary
KW  - Age Factors
KW  - Smoking
KW  - Cholesterol -- Analysis
KW  - Blood Glucose
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Human
SP  - 435
EP  - 443
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 3
IS  - 6
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - The conspicuous protection of premenopausal women from coronary heart disease is one of the remaining puzzles of cardiovascular disease epidemiology. The measurement of plasma estradiol levels in Framingham Offspring Study participants was undertaken to improve the understanding of the relationship of endogenous female hormones, which have long been suspected as the principle source of women's protection from coronary risk. Menstruating women aged 30 to 54 years who were not taking oral contraceptive medication and were free of cardiovascular disease were studied. Estradiol levels were found to show average decline of about 0.4% per year of age from age 30 to age 54. This decline was found to be attributable to cigarette smoking; cigarette smokers exhibited lower estradiol levels, particularly after age 40. As expected, women with larger subscapular skinfolds measurements had higher average estradiol and women who had higher levels of fitness had lower levels. Weak, not statistically significant, negative associations between self-reported measures of physical activity and estradiol levels generally supported the findings for fitness. The estimated impact of fitness on estradiol levels appears to be modest (0.3% decrease for every 1 min of additional treadmill time). Alcohol consumption, tubal ligation, and number of live births were not significantly related to estradiol levels. Variation in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol could be explained by body fatness and cigarette smoking but not by plasma estradiol levels. Only fasting plasma glucose level was found to be associated (inversely) with estradiol. This study, while adding to the wealth of data that document the adverse health consequences of cigarette smoking, does not support suggestions that naturally occurring variation in estradiol levels is a major determinant of lipoprotein metabolic function.
SN  - 1059-7115
AD  - Field Studies and Biometry Branch, National, Heart, Lung, and Blood Institute, 7550 Wisconsin Ave, Federal Bldg, Room 3A08, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kohn, Michael C.
AU  - Portier, Christopher J.
AU  - Lucier, George W.
T1  - The Importance of Biological Realism in Dioxin Risk Assessment Models.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1994/12//
VL  - 14
IS  - 6
M3  - Article
SP  - 993
EP  - 1000
SN  - 02724332
AB  - Mechanistic mathematical models of hepatocarcinogenesis in the female rat were constructed to investigate possible relationships among the Ah, estrogen, and EGF receptors in TCDD hepatocarcinogenicity. Each model generates dose-response curves for the expression of biomarker liver proteins CYP1A1, CYP1A2, and residual plasma membrane EGF receptor consequent to exposure to TCDD. The shapes of the response curves were strongly dependent on the assumed mechanisms of constitutive expression of these proteins. Assuming a constant level of the hepatic Ah receptor, a sigmoidal dose-response of hepatic CYP1A1 to total liver TCDD was computed. However, inclusion of induction of the Ah receptor by TCDD in a physiologically realistic dosimetric model produced a linear low-dose response of CYP1A1. This behavior was computed to arise from the net effect of sublinear response of CYP1A1 mRNA to the concentration of the Ah-TCDD complex and supralinear response of the protein concentration to the mRNA level, illustrating the importance of biological realism in dose-response modeling. The dosimetric model also computed effects of TCDD on the hepatic estradiol concentration and consequent effects on the binding capacity of the EGF receptor and suggests plausible mechanisms for tumor promotion by TCDD. Setting circulating estradiol levels in the model to values typical of the male rat indicated possible sources of the differences in the responses of the EGF receptor and in development of tumors in the two sexes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mathematical models
KW  - Biological models
KW  - Dioxins
KW  - Tetrachlorodibenzodioxin
KW  - Health risk assessment
KW  - 2, 3, 7, 8 -- Tetrachlorodibenzo-p-dioxin
KW  - Biological realism importance
KW  - Carcinogenesis
KW  - Dioxin
KW  - gene expression
KW  - Mathematical model
KW  - mathematical models
KW  - Risk assessment
N1  - Accession Number: 8114649; Kohn, Michael C. 1; Portier, Christopher J. 1; Lucier, George W. 2; Affiliations: 1: Laboratory of Quantitative and Computational Biology, National Institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, North Carolina 27709; 2: Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, North Carolina 27709; Issue Info: Dec94, Vol. 14 Issue 6, p993; Thesaurus Term: Mathematical models; Thesaurus Term: Biological models; Thesaurus Term: Dioxins; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Health risk assessment; Author-Supplied Keyword: 2, 3, 7, 8 -- Tetrachlorodibenzo-p-dioxin; Author-Supplied Keyword: Biological realism importance; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Dioxin; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: Mathematical model; Author-Supplied Keyword: mathematical models; Author-Supplied Keyword: Risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Sherman, Claire D.
AU  - Portier, Christopher J.
AU  - Kopp-Schneider, Annette
T1  - Multistage Models of Carcinogenesis: An Approximation for the Size and Number Distribution of Late-Stage Clones.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1994/12//
VL  - 14
IS  - 6
M3  - Article
SP  - 1039
EP  - 1048
SN  - 02724332
AB  - Multistage models have become the basic paradigm for modeling carcinogenesis. One model, the two-stage model of carcinogenesis, is now routinely used in the analysis of cancer risks from exposure to environmental chemicals. In its most general form, this model has two states, an initiated state and a neoplastic state, which allow for growth of cells via a simple linear birth--death process. In all analyses done with this model, researchers have assumed that tumor incidence is equivalent to the formation of a single neoplastic cell and the growth kinetics in the neoplastic state have been ignored. Some researchers have discussed the impact of this assumption on their analyses, but no formal methods were available for a more rigorous application of the birth--death process. In this paper, an approximation is introduced which allows for the application of growth kinetics in the neoplastic state. The adequacy of the approximation against simulated data is evaluated and methods are developed for implementing the approximation using data on the number and size of neoplastic clones. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogenesis
KW  - Environmental exposure
KW  - Environmentally induced diseases
KW  - Pollutants
KW  - Cancer -- Risk factors
KW  - Approximation evaluation
KW  - Cancer risk analysis
KW  - Clone, late-stage
KW  - Distribution, size and number
KW  - late-stage clones
KW  - Model, multistage
KW  - multistage models
N1  - Accession Number: 8114638; Sherman, Claire D. 1; Portier, Christopher J. 1; Kopp-Schneider, Annette 2; Affiliations: 1: Laboratory of Quantitative & Computational Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Biostatistiks, Deutsches Krebforschungzentrum, D6900 Heidelberg 1, Germany; Issue Info: Dec94, Vol. 14 Issue 6, p1039; Thesaurus Term: Carcinogenesis; Thesaurus Term: Environmental exposure; Thesaurus Term: Environmentally induced diseases; Thesaurus Term: Pollutants; Subject Term: Cancer -- Risk factors; Author-Supplied Keyword: Approximation evaluation; Author-Supplied Keyword: Cancer risk analysis; Author-Supplied Keyword: Clone, late-stage; Author-Supplied Keyword: Distribution, size and number; Author-Supplied Keyword: late-stage clones; Author-Supplied Keyword: Model, multistage; Author-Supplied Keyword: multistage models; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Sherman, Claire D.
AU  - Portier, Christopher J.
AU  - Kopp-Schneider, Annette
T1  - The Exact Formula for Tumor Incidence in the Two-Stage Model.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1994/12//
VL  - 14
IS  - 6
M3  - Article
SP  - 1079
EP  - 1080
SN  - 02724332
AB  - An exact formula for the tumor incidence rate in the usual two-stage model of carcinogenesis is presented. This formula is simple and easily implemented on calculators and computers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogenesis
KW  - CLASSIFICATION
KW  - Risk assessment
KW  - Biological models
KW  - Tumors
KW  - Cancer -- Risk factors
KW  - Cancer
KW  - Cancer risk assessment
KW  - Carcinogenesismodel, two-stage
KW  - Carcinogenicity data
KW  - Formula, exact
KW  - Mathematical analysis
KW  - Tumor incidence
N1  - Accession Number: 8114648; Sherman, Claire D. 1; Portier, Christopher J. 1; Kopp-Schneider, Annette 2; Affiliations: 1: Laboratory of Quantitative and Computational Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Abteilung Biostatistik, German Cancer Research Center, Heidelberg 1, Germany; Issue Info: Dec94, Vol. 14 Issue 6, p1079; Thesaurus Term: Carcinogenesis; Thesaurus Term: CLASSIFICATION; Thesaurus Term: Risk assessment; Thesaurus Term: Biological models; Subject Term: Tumors; Subject Term: Cancer -- Risk factors; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Cancer risk assessment; Author-Supplied Keyword: Carcinogenesismodel, two-stage; Author-Supplied Keyword: Carcinogenicity data; Author-Supplied Keyword: Formula, exact; Author-Supplied Keyword: Mathematical analysis; Author-Supplied Keyword: Tumor incidence; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Fernandez Buey, Francisco
AU  - Muntaner, Carles
AD  - National Institute of Mental Health, Bethesda, MD
AD  - U Pampeu Fabra
T1  - Marxisms against the Current: Weighing the Decade of the Eighties
JO  - Science and Society
JF  - Science and Society
Y1  - 1994///Winter 1994-1995
VL  - 58
IS  - 4
SP  - 471
EP  - 481
SN  - 00368237
N1  - Accession Number: 0352469; Keywords: Marxism; Publication Type: Journal Article; Update Code: 199507
KW  - History of Economic Thought since 1925: Socialist; Marxist; Sraffian          B24
L3  - http://guilfordjournals.com/loi/siso
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UR  - http://guilfordjournals.com/loi/siso
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Hoak, John C.
T1  - Stearic acid, clotting, and thrombosis.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1994/12/02/Dec1994 Supplement
M3  - Article
SP  - 1050S
EP  - 1053S
SN  - 00029165
AB  - Stearic acid causes hypercoagulability of the blood by activation of factor XII and by aggregation of blood platelets. Injection of unbound stearic acid (sodium salt) into the systemic circulation of dogs was followed by massive generalized thrombosis and sudden death. Similar infusions into birds. which are deficient in factor XII, did not cause hypercoagulability or thrombosis. The effects of the long-chain saturated fatty acids could be prevented by using albumin to bind the stearic acid at a molar ratio of free fatty acid (FFA) to albumin of < 2. The major issue is whether eating foods rich in stearic acid can cause a thrombogenic effect. We have no experimental evidence to support this concept. If a thrombogenic effect of long-chain saturated fatty acids exists in humans, it is most likely to occur as an aberration of fatty acid transport in which the FFA-albumin molar ratio exceeds 2 either as a result of very high plasma FFA concentrations from lipid mobilization or a low concentration of albumin in the blood as found in disease states such as the nephrotic syndrome. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Albumins
KW  - Stearic acid
KW  - Thrombosis
KW  - Blood coagulation
KW  - Blood platelet activation
KW  - Nephrotic syndrome
KW  - coagulation
KW  - platelets
KW  - Steanic acid
KW  - thrombosis
N1  - Accession Number: 94424885; Hoak, John C. 1; Affiliations: 1: Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; Issue Info: Dec1994 Supplement, p1050S; Thesaurus Term: RESEARCH; Thesaurus Term: Albumins; Subject Term: Stearic acid; Subject Term: Thrombosis; Subject Term: Blood coagulation; Subject Term: Blood platelet activation; Subject Term: Nephrotic syndrome; Author-Supplied Keyword: coagulation; Author-Supplied Keyword: platelets; Author-Supplied Keyword: Steanic acid; Author-Supplied Keyword: thrombosis; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107369539
T1  - Stearic acid, clotting, and thrombosis... presented at Metabolic Consequences of Stearic Acid Relative to Other Long-Chain Fatty Acids and at Chocolate in Perspective: Cocoa Butter, a Unique Saturated Fat.
AU  - Hoak JC
Y1  - 1994/12/02/Dec1994 Supplement
N1  - Accession Number: 107369539. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; proceedings; tables/charts. Supplement Title: Dec1994 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Fatty Acids, Saturated -- Pharmacodynamics
KW  - Blood Coagulation -- Drug Effects
KW  - Thrombosis -- Etiology
KW  - Blood Platelets -- Drug Effects
KW  - Lipids -- Metabolism
KW  - Fatty Acids -- Adverse Effects
KW  - Thrombosis -- Physiopathology
SP  - 1050S
EP  - 3S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 7977149.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850842
T1  - Treatment of locally advanced cancer of the head and neck with 5'-iododeoxyuridine and hyperfractionated radiation therapy: measurement of cell labeling and thymidine replacement.
AU  - Epstein AH
AU  - Lebovics RS
AU  - Goffman T
AU  - Teague D
AU  - Fuetsch ES
AU  - Glatstein E
AU  - Okunieff P
AU  - Cook JA
Y1  - 1994/12/07/
N1  - Accession Number: 105850842. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Deoxyribonucleosides -- Therapeutic Use
KW  - Head and Neck Neoplasms -- Drug Therapy
KW  - Head and Neck Neoplasms -- Radiotherapy
KW  - Adult
KW  - Aged
KW  - Chromatography, High Pressure Liquid
KW  - Combined Modality Therapy
KW  - Deoxyribonucleosides -- Administration and Dosage
KW  - Female
KW  - Flow Cytometry
KW  - Head and Neck Neoplasms -- Pathology
KW  - Infusions, Intravenous
KW  - Male
KW  - Middle Age
KW  - Pilot Studies
KW  - Radiotherapy -- Methods
KW  - Time Factors
KW  - Human
SP  - 1775
EP  - 1780
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 86
IS  - 23
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Radiation Oncology Branch, National Cancer Institute, Bethesda, Md.
U2  - PMID: 7966416.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107145220
T1  - Menstrual cycle patterns and risk of breast cancer.
AU  - Whelan EA
AU  - Sandler DP
AU  - Root JL
AU  - Smith KR
AU  - Weinberg CR
Y1  - 1994/12/15/
N1  - Accession Number: 107145220. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Supported in part by grant R03 CA48908-01 from the National Cancer Institute and by US Public Health Service Research Grant NO1-R00064 from the National Center for Research Resource. NLM UID: 7910653. 
KW  - Breast Neoplasms -- Epidemiology
KW  - Menstrual Cycle
KW  - Funding Source
KW  - Prospective Studies
KW  - Survey Research
KW  - Descriptive Statistics
KW  - Regression
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Multivariate Analysis
KW  - Questionnaires
KW  - Female
KW  - Human
SP  - 1081
EP  - 1090
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 140
IS  - 12
PB  - Oxford University Press / USA
AB  - Menstrual cycle characteristics may reflect underlying endocrine patterns that influence the risk of breast cancer. Most previous studies of menstrual function and breast cancer risk have used retrospective reports of menstrual bleeding, which may be unreliable. To examine this association, the authors conducted a mail survey among 997 women who had recorded menstrual events prospectively over as many as 50 years, beginning in 1934. Compared with women with a median menstrual cycle length of 26-29 days, women who had cycles of extreme length at ages 25-29 years had a nearly twofold increased incidence of breast cancer (for a median cycle length of less than 26 days, adjusted relative risk (RR) = 1.9, 95% CI 0.9-4.1; for >/= 34 days, RR = 1.9, 95% CI 0.9-3.9). Statistical adjustment was made for age, family history of breast cancer, parity, age at menopause, age at first pregnancy, and Quetelet index (weight (kg)/height (m)2). Adjusting for age and other potential confounders and restricting the analysis to women who did not use hormones, women who experienced either a lesser (<150) or a greater (>350) cumulative number of cycles had an increased incidence of breast cancer (adjusted RR = 1.9, 95% CI 0.3-10.6, and RR = 1.8, 95% CI 0.5-6.0, respectively) compared with women who experienced 150-350 cycles. The findings are discussed in the context of current hormonal theories of breast cancer etiology.
SN  - 0002-9262
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC
U2  - PMID: 7998590.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107145220&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850858
T1  - Residential radon exposure and lung cancer among nonsmoking women.
AU  - Alavanja MC
AU  - Brownson RC
AU  - Lubin JH
AU  - Berger E
AU  - Chang J
AU  - Boice JD Jr
Y1  - 1994/12/21/
N1  - Accession Number: 105850858. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Adenocarcinoma -- Etiology
KW  - Air Pollution, Indoor -- Adverse Effects
KW  - Lung Neoplasms -- Etiology
KW  - Neoplasms, Radiation-Induced -- Etiology
KW  - Radioactive Pollution -- Adverse Effects
KW  - Radon -- Adverse Effects
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Case Control Studies
KW  - Data Collection
KW  - Dose-Response Relationship, Radiation
KW  - Female
KW  - Middle Age
KW  - Missouri
KW  - Radon -- Analysis
KW  - Smoking Cessation
KW  - Human
SP  - 1829
EP  - 1837
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 86
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Md 20892.
U2  - PMID: 7990157.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850858&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850859
T1  - Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model.
AU  - Casciari JJ
AU  - Hollingshead MG
AU  - Alley MC
AU  - Mayo JG
AU  - Malspeis L
AU  - Miyauchi S
AU  - Grever MR
AU  - Weinstein JN
Y1  - 1994/12/21/
N1  - Accession Number: 105850859. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Cells
KW  - Colony-Forming Units Assay -- Methods
KW  - Antineoplastic Agents -- Pharmacodynamics
KW  - Biocompatible Materials
KW  - Cell Physiology -- Drug Effects
KW  - Cells -- Drug Effects
KW  - Colorimetry
KW  - Dose-Response Relationship, Drug
KW  - Doxorubicin -- Pharmacodynamics
SP  - 1846
EP  - 1852
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 86
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Developmental Therapeutics Program, National Cancer Institute, Bethesda, Md 20892.
U2  - PMID: 7990159.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850859&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105850862
T1  - Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents.
AU  - van Osdol WW
AU  - Myers TG
AU  - Paull KD
AU  - Kohn KW
AU  - Weinstein JN
Y1  - 1994/12/21/
N1  - Accession Number: 105850862. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Algorithms
KW  - Antineoplastic Agents -- Pharmacodynamics
SP  - 1853
EP  - 1859
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 86
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory for Molecular Pharmacology, National Cancer Institute, Bethesda, Md 20892.
U2  - PMID: 7990160.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850862&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - Gen
ID  - 9999-07498-000
AN  - 9999-07498-000
AU  - Najavits, Lisa M.
AU  - Griffin, Margaret L.
AU  - Luborsky, Lester
AU  - Frank, Arlene
AU  - Weiss, Roger D.
AU  - Liese, Bruce S.
AU  - Thompson, Heather
AU  - Nakayama, Emilie
AU  - Siqueland, Lynne
AU  - Daley, Dennis
AU  - Onken, Lisa Simon
T1  - Ratings of Emotional Attitudes to Clients by Treaters
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1995///
AD  - Najavits, Lisa M., McLean Hospital, Alcohol and Drug Abuse Program, 115 Mill Street, Belmont, Massachusetts, United States, 01278-9106
AV  - Commercial: No; Permissions: Contact Corresponding Author; Fee: Unknown. Test Items: No
N1  - Accession Number: 9999-07498-000. Acronyms: REACT. Partial author list: First Author & Affiliation: Najavits, Lisa M.; Harvard Medical School/McLean Hospital, Alcohol and Drug Abuse Program, Belmont, Massachusetts, United States. Release Date: 20120507. Instrument Type: Rating Scale. Test Format: Therapists rate their emotional responses to each patient on a 0 to 6 scale.. Language: English. Constructs: Therapist  Reactions; Classification: Treatment, Rehabilitation, and Therapeutic Processes (7900). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the modified Ratings of Emotional Attitudes to Clients by Treaters is to assess therapists' emotional responses to substance abuse patients.
AB  - Description: The Ratings of Emotional Attitudes to Clients by Treaters (REACT; Najavits & Colson, 1992) was developed to measure emotional responses of therapists to their substance abuse patients. The 40-item REACT was based in part on the scale used by Colson et al. (1986), but expanded to include variables theorized as most relevant to substance abuse therapists (REACT; Najavits et al., 1995). Two subscales ('positive feelings' and 'negative feelings') were rationally defined a priori based on a clear direction of the items, and consisted of 12 and 23 items respectively. The instrument takes about five minutes to complete, and was administered at three time points to substance-abusing clients: after the second, fifth, and 24th sessions of treatment. These sessions were chosen to provide test-retest information; as well as across the length of treatment (24th session). Internal consistency was found to be consistently high. Items 1-38 were included in the factor analysis; item 39 ('had dreams about the patient') was omitted due to lack of variance and item 40 was omitted because it referred to write-in responses of 'other emotions.' A four-factor solution offered the most meaningful interpretation while accounting for a relatively high proportion of variance. The four factors might be labeled as 'therapist in conflict with self' (11 items), 'therapist focused on own needs' (7 items), 'positive connection to the patient' (6 items), and 'therapist in conflict with patient' (4 items). To explore the relationship between the REACT and therapeutic alliance measures, two-tailed Pearson correlations were conducted using the means of each measure (with the REACT calculated as the mean of all 35 'positive-feeling' and 'negative-feeling' items, with reverse scoring of the latter). The REACT total score was correlated with the two alliance measures (Helping Alliance Questionnaire-II and California Psychotherapy Alliance Scale) at three time points. Results showed moderately strong correlations with the therapist versions of the instruments, and lower correlations with the patient versions. (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW  - Factor Analysis
KW  - Ratings of Emotional Attitudes to Clients by Treaters
KW  - Test Development
KW  - Test Reliability
KW  - Test Validity
KW  - Therapist in Conflict with Self
KW  - Therapist Focused on Own Needs
KW  - Positive Connection to the Patient
KW  - Therapist in Conflict with the Patient
U5  - Ratings of Emotional Attitudes to Clients by Treaters (REACT) [Test Development]Therapists' emotional reactions to substance abusers: A new questionnaire and initial findings. (AN: 1996-00446-016 from PsycINFO) Najavits, Lisa M.; Griffin, Margaret L.; Luborsky, Lester; Frank, Arlene; Weiss, Roger D.; Liese, Bruce S.; Thompson, Heather; Nakayama, Emilie; Siqueland, Lynne; Daley, Dennis; Onken, Lisa Simon; Win, 1995. Source: Psychotherapy: Theory, Research, Practice, Training. 32(4), Division of Psychotherapy (29), American Psychological Association, US; Win, 1995; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Outpatient; Location: United States; Sample: Therapists and Patients Keywords: Factor Analysis; Ratings of Emotional Attitudes to Clients by Treaters; Test Development; Test Reliability; Test Validity; Therapist in Conflict with Self; Therapist Focused on Own Needs; Positive Connection to the Patient; Therapist in Conflict with the Patient; Subjects: Factor Analysis; Patients; Psychotherapeutic Processes; Test Construction; Test Reliability; Test Validity; Therapist Attitudes;
DO  - 10.1037/t07498-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07498-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-01505-000
AN  - 9999-01505-000
AU  - Singleton,, E. G.
AU  - Tiffany, S. T.
AU  - Henningfield, J.  E.
T1  - Alcohol Craving Questionnaire-NOW
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1995///
AD  - Singleton,, E. G., 5 Elderberry Court, Baltimore, Maryland, United States, 21228-1008
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-01505-000. Acronyms: ACQ-NOW. Partial author list: First Author & Affiliation: Singleton,, E. G.; National Institutes of Health, National Institute on Drug Abuse ,  Intramural Research Program, Rockville, Maryland, United States. Release Date: 20120611. Instrument Type: Inventory/Questionnaire. Test Format: Respondents indicate the degree to which they agree with each statement along a 7-point Likert-type scale ranging from 'Strongly disagree' to 'Strongly agree'.. Language: English. Constructs: Alcohol Craving; Classification: Addiction, Gambling, and Substance Abuse/Use (5000). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Electronic
AB  - Purpose: The ACQ-NOW is a multidimensional state measure of acute alcohol craving in the present moment.
AB  - Description: The Alcohol Craving Questionnaire-NOW (ACQ-NOW; Singleton, Tiffany, & Henningfield, 1994) is a 47-item self-administered, multidimensional state measure of acute alcohol craving adapted from the Cocaine Craving Questionnaire of Tiffany et al (1993). As such, it measures four dimensions (subscales) of alcohol craving labeled Emotionality, Purposefulness, Compulsivity, and Expectancy. It takes 5 to 10 minutes to complete for persons with a seventh grade reading level or above. The Respondents indicate the degree to which they agree with each statement along a 7-point Likert-type scale ranging from 'Strongly disagree' to 'Strongly agree'. The ACQ-NOW has moderate to high reliability (alpha) and is sensitive to change. (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW  - Alcohol Craving Questionnaire-NOW
KW  - Convergent Validity
KW  - Divergent Validity
KW  - Factor Analysis
KW  - Factor Structure
KW  - Internal Consistency
KW  - Subscale Models
KW  - Psychometric Properties
U5  - Alcohol Craving Questionnaire-NOW (ACQ-NOW) [Test Review]Evaluation of the Alcohol Craving Questionnaire-Now factor structures: Application of a cue reactivity paradigm. (AN: 2009-07708-012 from PsycINFO) Connolly, Kevin M.; Coffey, Scott F.; Baschnagel, Joseph S.; Drobes, David J.; Saladin, Michael E.; Jul, 2009. Source: Drug and Alcohol Dependence. 103(1-2), Elsevier Science, Netherlands; Jul, 2009; Administration: Electronic Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Location: United States; Sample: Adult Social and Alcohol Dependent Drinkers Keywords: Alcohol Craving Questionnaire-NOW; Convergent Validity; Divergent Validity; Factor Analysis; Factor Structure; Internal Consistency; Subscale Models; Psychometric Properties; Subjects: Alcohol Abuse; Craving; Factor Analysis; Factor Structure; Questionnaires; Subtests; Test Reliability; Test Validity;
DO  - 10.1037/t01505-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-01505-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Reinert, Duane F.
AU  - Estadt, Barry K.
AU  - Fenzel, L. Mickey
AU  - Gilroy, Faith D.
AU  - Allen, John P.
T1  - Relationship of Surrender and Narcissism to Involvement in Alcohol Recovery.
JO  - Alcoholism Treatment Quarterly
JF  - Alcoholism Treatment Quarterly
Y1  - 1995/01//
VL  - 12
IS  - 1
M3  - Article
SP  - 49
EP  - 58
SN  - 07347324
AB  - Subjects were participants in two self-help groups, Alcoholics Anonymous (AA; n = 45) and Rational Recovery (RR; n = 10). Two groups of AA participants were distinguished based on degree of AA involvement. RR participants constituted the third group. As predicted, the Surrender instrument was able to discriminate between the High AA, Low AA, and RR groups, with the High AA group scoring above the other groups on surrender. Results suggest there is more to the act of surrender than level of involvement, length of sobriety, or degree of dependence on alcohol. Some support is provided for AA's philosophy that surrendering to a Higher Power occurs during the course of alcohol recovery. Results suggested there is a negative correlation between pathological narcissism and surrender. Unfortunately, firm conclusions could not be drawn from this study regarding narcissism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Alcoholism Treatment Quarterly is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOLICS
KW  - SUPPORT groups
KW  - ALCOHOLISM
KW  - NARCISSISM
KW  - ADDICTS
N1  - Accession Number: 9501181745; Reinert, Duane F. 1 Estadt, Barry K. 1 Fenzel, L. Mickey 2 Gilroy, Faith D. 2 Allen, John P. 3; Affiliation:  1: Pastoral Counseling Department, Loyola College, Maryland  2: Department of Psychology, Conception Seminary College, Conception, MO 64433-0502  3: National Institute on Alcohol Abuse and Alcoholism; Source Info: 1995, Vol. 12 Issue 1, p49; Subject Term: ALCOHOLICS; Subject Term: SUPPORT groups; Subject Term: ALCOHOLISM; Subject Term: NARCISSISM; Subject Term: ADDICTS; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nelson, David E.
AU  - Giovino, Gary A.
AU  - Shopland, Donald R.
AU  - Mowery, Paul D.
AU  - Mills, Sherry L.
AU  - Eriksen, Michael P.
T1  - Trends in Cigarette Smoking among US Adolescents, 1974 through 1991.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/01//
VL  - 85
IS  - 1
M3  - Article
SP  - 34
EP  - 40
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The purpose of this study was lo determine national trends in adolescent cigarette smoking prevalence. Methods. We conducted trend analyses based on 1974 through 1991 current smoking prevalence data among persons aged 12 through 19 years from the National Household Surveys on Drug Abuse, High School Seniors Surveys, and National Health Interview Surveys. Results. Overall smoking prevalence declined much more rapidly from 1974 through 1980 (1.9 percentage points annually among younger adolescents; the range among surveys of older adolescents was 0.2 to 2.0 percentage points annually) than from 1985 through 1991 (0 to 0.5 percentage points annually among all adolescents). Since 1980, smoking has generally declined at a slightly faster rate among older female adolescents than among male adolescents. Smoking among Black adolescents of all ages declined in nearly every survey population during each study period (range among surveys; 1974-1985 = 1.0 to 2.9 percentage points; 1985-1991 = 0.7 to 1.5 percentage points annually); for White adolescents, only minimal declines in smoking have occurred since 1985. Conclusions. Since 1974, major changes in adolescent smoking patterns have occurred, especially among Blacks. The overall slowing rate of decline in smoking prevalence since 1985 may indicate success of increased tobacco advertising and promotional activities targeted at adolescents or inadequate antitobacco education efforts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIGARETTE smokers
KW  - TEENAGERS
KW  - SMOKING
KW  - SURVEYS
KW  - SUBSTANCE abuse
KW  - DRUGS of abuse
N1  - Accession Number: 9502140575; Nelson, David E. 1 Giovino, Gary A. 2 Shopland, Donald R. 3 Mowery, Paul D. 4 Mills, Sherry L. 3 Eriksen, Michael P. 2; Affiliation:  1: Office of Surveillance and Analysis, Centers for Diseases Control and Prevention  2: Office on Smoking and Health, Centers for Disease Control and Prevention  3: National Cancer Institute National Institute of Health, Bethesda, Md.  4: Battelle Inc., Arlington, Va.; Source Info: Jan1995, Vol. 85 Issue 1, p34; Subject Term: CIGARETTE smokers; Subject Term: TEENAGERS; Subject Term: SMOKING; Subject Term: SURVEYS; Subject Term: SUBSTANCE abuse; Subject Term: DRUGS of abuse; Number of Pages: 7p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Archer, Loran
AU  - Grant, Bridget F.
AU  - Dawson, Deborah A
T1  - What if Americans Drank Less?  The Potential Effect on the Prevalence of Alcohol Abuse and Dependence.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/01//
VL  - 85
IS  - 1
M3  - Article
SP  - 61
EP  - 66
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Several advisory committees have recently recommended that alcohol consumption be limited to moderate levels. Moderate drinking has been defined generally as not more than two drinks per day for healthy men and not more than one drink per day for healthy, nonpregnant women. The impact of reducing alcohol consumption to within the recommended, guidelines on the prevalence of two serious alcohol-related problems was examined by modeling the relationship between average daily ethanol intake and alcohol abuse and dependence. Methods. The recommended drinking guidelines, both in their existing form and modified by a measure of impairment, were applied to the observed distribution of consumption derived from a large representative survey of the US general population. Results. The results demonstrated that restricting drinking to the maximum allowable levels under the existing and the modified guidelines would reduce the prevalence of alcohol abuse and dependence by 14.2% and 47.1%, respectively, in the adult US general population. Conclusions. Implications of these findings are discussed in terms of the validity of the assumptions underlying the models and the nature and direction of future research that would form the basis of newly developed guidelines for safe drinking limits. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOL
KW  - DRINKING of alcoholic beverages
KW  - DRINKING behavior
KW  - ALCOHOLISM
KW  - WOMEN
KW  - UNITED States
N1  - Accession Number: 9502140590; Archer, Loran 1 Grant, Bridget F. 1 Dawson, Deborah A 1; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism, Rockville, Md.; Source Info: Jan1995, Vol. 85 Issue 1, p61; Subject Term: ALCOHOL; Subject Term: DRINKING of alcoholic beverages; Subject Term: DRINKING behavior; Subject Term: ALCOHOLISM; Subject Term: WOMEN; Subject Term: UNITED States; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hartel, Diana M.
AU  - Schoenbaum, Ellie E.
AU  - Selwyn, Peter A.
AU  - Kline, Jennie
AU  - Davenny, Katherine
AU  - Klein, Robert S.
AU  - Friedland, Gerald H.
T1  - Heroin Use During Methadone Maintenance Treatment: The Importance of Methadone Dose and Cocaine Use.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/01//
VL  - 85
IS  - 1
M3  - Article
SP  - 83
EP  - 88
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The purpose of this study was to examine factors associated with heroin use during methadone maintenance treatment. Methods. Logistic regression statistical models were used to examine data obtained in a cross-sectional sample of 652 methadone patients. Results. Heroin use during the 3 months prior to interview was shown to be greatest among (1) patients maintained on methadone dosages of less than 70 mg/day (adjusted odds ratio [OR] = 2.1, 95% confidence interval [CI] = 1.3, 3.4) and (2) patients who used cocaine during treatment (adjusted OR = 5.9, 95% CI = 3.8, 9.1). These results were independent of treatment duration, treatment compliance, alcohol use, and socioeconomic factors. Cocaine users were more likely than nonusers of cocaine to use heroin at all methadone dosage levels. Conclusions. This study confirms and extends past research showing high-dose methadone maintenance to be important to heroin abstinence. Further investigation of the independent association between heroin use and cocaine use is needed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEROIN
KW  - METHADONE treatment programs
KW  - DRUG abuse -- Treatment
KW  - COCAINE
KW  - DRUG abuse
KW  - SUBSTANCE abuse
N1  - Accession Number: 9502140607; Hartel, Diana M. 1 Schoenbaum, Ellie E. 1 Selwyn, Peter A. 2 Kline, Jennie 3,4 Davenny, Katherine 5 Klein, Robert S. 1 Friedland, Gerald H. 2; Affiliation:  1: Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY  2: AIDS Program, Yale University School of Medicine, New Haven, Conn.  3: New York State Psychiatric Institute  4: Sergievsky Center, Columbia University, New York City  5: National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md.; Source Info: Jan1995, Vol. 85 Issue 1, p83; Subject Term: HEROIN; Subject Term: METHADONE treatment programs; Subject Term: DRUG abuse -- Treatment; Subject Term: COCAINE; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107425951
T1  - Education and change in cognitive function: the epidemiologic catchment area study.
AU  - Farmer ME
AU  - Kittner SJ
AU  - Rae DS
AU  - Bartko JJ
AU  - Regier DA
Y1  - 1995/01//1995 Jan
N1  - Accession Number: 107425951. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 9100013. 
KW  - Educational Status
KW  - Cognition
KW  - Interviews
KW  - Prospective Studies
KW  - Socioeconomic Factors
KW  - Logistic Regression
KW  - Substance Abuse
KW  - Residence Characteristics
KW  - Aging
KW  - Odds Ratio
KW  - Dementia
KW  - Research Instruments
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1
EP  - 7
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 5
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
AB  - The association between educational attainment and decline in cognitive function over an interval of 1 year was examined for 14,883 subjects 18 years and older in the National Institute of Mental Health Epidemiologic Catchment Area Study. Cognitive function was assessed at both time points by the Mini-Mental State Examination (MMSE); cognitive decline was coded as a dichotomous variable and was defined as 1 if the subject's score had declined 3 or more points from the baseline MMSE score at the 1-year-follow-up interview and as 0 otherwise. The association between educational attainment and decline in cognitive function over 1 year was examined in logistic regression models that were stratified by age group (< 65 years, > or = 65 years) and by baseline MMSE level (MMSE > 23, MMSE < or = 23). Covariates included age, baseline MMSE score, ethnicity, residence, lifetime diagnosis of abuse of alcohol or other drugs, and gender. In those with baseline MMSE > 23, education was a significant predictor of cognitive decline, not only in the elderly but also in younger subjects. Among those with baseline MMSE < or = 23, education was not a significant predictor of cognitive decline. The fact that education provides protection against cognitive decline even in those younger than 65 years, in whom the prevalence and incidence of dementia are very low, would seem to indicate that education or its correlates provides protection against processes other than dementia that might produce a decline in test performance in young persons.
SN  - 1047-2797
AD  - Epidemiology and Psychopathology Research Branch/National Institute of Mental Health, Rm 10C-09, Parklawn Bldg, 5600 Fishers Lane, Rockville, MD 20857
U2  - PMID: 7728280.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107034309
T1  - Chemoprevention.
AU  - Greenwald P
AU  - Kelloff G
AU  - Burch-Whitman C
AU  - Kramer BS
Y1  - 1995/01//Jan/Feb95
N1  - Accession Number: 107034309. Language: English. Entry Date: 20010629. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0370647. 
KW  - Chemoprevention
KW  - Clinical Trials
SP  - 31
EP  - 49
JO  - CA: A Cancer Journal for Clinicians
JF  - CA: A Cancer Journal for Clinicians
JA  - CA
VL  - 45
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0007-9235
AD  - Director, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD
U2  - PMID: 7804897.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107422887
T1  - Effects of gestational diabetes on perinatal morbidity reassessed: report of the International workshop on Adverse Perinatal Outcomes of Gestational Diabetes Mellitus, December 3-4, 1992.
AU  - Blank A
AU  - Grave GD
AU  - Metzger BE
Y1  - 1995/01//
N1  - Accession Number: 107422887. Language: English. Entry Date: 19951001. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Diabetes Mellitus, Gestational
KW  - Pregnancy Outcomes
KW  - Morbidity -- In Infancy and Childhood
KW  - Infant, Newborn
KW  - Pregnancy
KW  - Female
SP  - 127
EP  - 129
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 18
IS  - 1
CY  - Alexandria, Virginia
PB  - American Diabetes Association
SN  - 0149-5992
AD  - National Institute of Child Health and Human Development, Office of Research Reporting, Bldg 31, Rm 2A32, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 7698033.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Juster, F. Thomas
AU  - Suzman, Richard
AD  - National Institute on Aging
AD  - National Institute on Aging
T1  - An Overview of the Health and Retirement Study
JO  - Journal of Human Resources
JF  - Journal of Human Resources
Y1  - 1995///
VL  - 30
SP  - S7
EP  - 56
SN  - 0022166X
N1  - Accession Number: 0374026; Keywords: Health;  Retirement; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199603
N2  - This paper examines the scientific, public policy, and organizational background out of which the Health and Retirement Study emerged. It describes the evolution of the major parameters of the survey and the unique planning structure designed to ensure that the substantive insights of the research community were fully reflected in the content of the database, highlights key survey innovations contained in the HRS, and provides a preliminary assessment of the quality of the data as reflected by sample size, sample composition, response rate, and survey content. The paper also describes the several types of administrative data that are expected to be added to the HRS data: earnings and benefits from Social Security files, and health insurance and pension data from the employers of survey respondents.
KW  - Demographic Economics: General          J10
KW  - Health: General          I10
KW  - Retirement; Retirement Policies          J26
L3  - http://jhr.uwpress.org/content/by/year
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UR  - http://jhr.uwpress.org/content/by/year
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 107394222
T1  - How do patients with Alzheimer's disease cope with their illness? -- a clinical experience report.
AU  - Bahro M
AU  - Silber E
AU  - Sunderland T
Y1  - 1995/01//1/ 1/1995
N1  - Accession Number: 107394222. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Adaptation, Psychological -- In Old Age
KW  - Alzheimer's Disease -- Psychosocial Factors
KW  - Coping
KW  - Aged
KW  - Aged, 80 and Over
KW  - Alzheimer's Disease -- Therapy
KW  - Anxiety
KW  - Denial (Psychology)
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Self Concept
SP  - 41
EP  - 46
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - Section on Geriatric Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, NIH Clinical Center, Building 10, Room 3D41, Bethesda, MD 20892
U2  - PMID: 7806738.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107394236
T1  - Report from the NIA. Osteoporosis: emerging research strategies aim at bone biology, risk factors, interventions.
AU  - Hodes RJ
Y1  - 1995/01//1/ 1/1995
N1  - Accession Number: 107394236. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Osteoporosis
KW  - Aged
KW  - Clinical Trials
KW  - Male
KW  - Osteoporosis -- Etiology
KW  - Osteoporosis -- Prevention and Control
KW  - Postmenopause
KW  - Risk Factors
SP  - 75
EP  - 77
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - National Institute on Aging, Office of the Director, Bldg 31, Room 5C35, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 7806746.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107394236&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Korn, Edward L.
AU  - Graubard, Barry I.
AD  - National Cancer Institute
AD  - National Cancer Institute
T1  - Analysis of Large Health Surveys: Accounting for the Sampling Design
JO  - Journal of the Royal Statistical Society: Series A (Statistics in Society)
JF  - Journal of the Royal Statistical Society: Series A (Statistics in Society)
Y1  - 1995///
VL  - 158
IS  - 2
SP  - 263
EP  - 295
SN  - 00359238
N1  - Accession Number: 0368815; Keywords: Health;  Sampling; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199512
KW  - Health: General          I10
KW  - Survey Methods; Sampling Methods          C83
L3  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291467-985X/issues
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UR  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291467-985X/issues
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 107401064
T1  - When eating becomes disordered: overcoming a distorted self-image.
AU  - Strauss LA
Y1  - 1995/01//1995 Jan-Feb
N1  - Accession Number: 107401064. Language: English. Entry Date: 19950301. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 0211506. 
KW  - Eating Disorders -- Diagnosis
KW  - Eating Disorders -- Therapy
KW  - Information Resources
KW  - Body Image
KW  - Eating Disorders -- Epidemiology
SP  - 17
EP  - 20
JO  - Professional Medical Assistant
JF  - Professional Medical Assistant
JA  - PROF MED ASSIST
VL  - 28
IS  - 1
CY  - Chicago, Illinois
PB  - American Association of Medical Assistants
SN  - 0033-0140
AD  - National Institutes of Health
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Ashery, Rebecca Sager
AU  - Carlson, Robert G.
AU  - Falck, Russel S.
AU  - Siegal, Harvey A.
T1  - Injection Drug Users, Crack-Cocaine Users, and Human Services Utilization: An Exploratory Study.
JO  - Social Work
JF  - Social Work
Y1  - 1995/01//
VL  - 40
IS  - 1
M3  - Article
SP  - 75
EP  - 82
PB  - Oxford University Press / USA
SN  - 00378046
AB  - The article describes the interaction of drug abusers with the social services system. Human services organizations are designed to help people move toward and maintain optimum levels of physical and psychosocial health. When the people needing assistance are injection drug users and crack-cocaine users, perhaps the most highly marginalized individuals in society, the ability of the system to deliver services is severely tested. In addition, because drug addiction is perceived and addressed in the U.S. primarily as a criminal justice problem rather than a social or public health problem, drug users' interactions with the human services system may be even more strained. Previous research on the use of social services by users of illegal drugs who are not undergoing treatment is virtually nonexistent. Although the heroin addicts in treatment experienced many more problems than the nonaddicted women in every life domain considered, they sought help from the human services system no more frequently than nonaddicts. Interestingly, African Americans, regardless of drug use status, were less likely to use social services and more likely to rely on informal support systems for problem resolution than white people.
KW  - DRUG abuse
KW  - SOCIAL services
KW  - HUMAN services
KW  - ORGANIZATION
KW  - HEALTH
KW  - CRACK cocaine
KW  - ADDICTIONS
KW  - SUBSTANCE abuse
KW  - CRIMINAL justice administration
KW  - DRUGS of abuse
KW  - AIDS
KW  - drug abusers
KW  - focus groups
KW  - service utilization
KW  - social services system
N1  - Accession Number: 9510161949; Ashery, Rebecca Sager 1 Carlson, Robert G. 2 Falck, Russel S. 3 Siegal, Harvey A. 4,5; Affiliation:  1: Senior social work specialty consultant, National Institute on Drug Abuse, Community Research Branch, Rockville, MD.  2: Assistant professor, Department of Community Health, and director of ethnographic research, Dayton/Columbus AIDS Prevention Project, Wright State University School of Medicine, 143 Biological Sciences Building, 3640 Colonel Glenn Highway, Dayton, OH 45435.  3: Project director, Dayton/Columbus AIDS Prevention Project  4: Professor, Department of Community Health, Wright State University School of Medicine  5: Principal investigator, Dayton/Columbus AIDS Prevention Project, Dayton, OH.; Source Info: Jan95, Vol. 40 Issue 1, p75; Subject Term: DRUG abuse; Subject Term: SOCIAL services; Subject Term: HUMAN services; Subject Term: ORGANIZATION; Subject Term: HEALTH; Subject Term: CRACK cocaine; Subject Term: ADDICTIONS; Subject Term: SUBSTANCE abuse; Subject Term: CRIMINAL justice administration; Subject Term: DRUGS of abuse; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: drug abusers; Author-Supplied Keyword: focus groups; Author-Supplied Keyword: service utilization; Author-Supplied Keyword: social services system; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 4661
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
AU  - Newman, David
AD  - National Cancer Institute
A2  - Hooten, Anthony J.
A2  - Hatziolos, Marea E.
T1  - Marine Bioprospecting
T2  - Sustainable financing mechanisms for coral reef conservation: Proceedings of a workshop held at the World Bank, Washington, D.C., June 23, 1995
PB  - Environmentally Sustainable Development Proceedings Series, no. 9.
PB  - Washington, D.C.:
PB  - World Bank
Y1  - 1995///
SP  - 38
EP  - 42
N1  - Accession Number: 0447879; Reviewed Book ISBN: 0-8213-3490-5; ; Publication Type: Collective Volume Article; Update Code: 199805
KW  - Renewable Resources and Conservation: Other          Q29
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 2015-37188-033
AN  - 2015-37188-033
AU  - Li, Amen
AU  - Lane, William S.
AU  - Johnson, Lincoln V.
AU  - Chader, Gerald J.
AU  - Tombran-Tink, Joyce
T1  - Neuron-specific enolase: A neuronal survival factor in the retinal extracellular matrix?
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/01//
VL  - 15
IS  - 1
SP  - 385
EP  - 393
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Tombran-Tink, Joyce, National Eye Institute, National Institutes of Health, Building 6, Room 311, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37188-033. PMID: 7823143 Partial author list: First Author & Affiliation: Li, Amen; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neurons; Photoreceptors; Retina. Minor Descriptor: Antibodies; Morphology; Peptides. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: Jan, 1995. Publication History: Accepted Date: Jun 22, 1994; Revised Date: Jun 20, 1994; First Submitted Date: Feb 25, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - To identify soluble proteins of the retinal interphotoreceptor matrix (IPM), we isolated IPM from the bovine eye by gentle lavage and subjected it to SDS-PAGE. In the resultant gel, a 46 kDa band was particularly prominent and appeared to be a single protein. This protein was electroblotted to nitrocellulose membrane, digested with trypsin, and selected peptides were isolated by HPLC and subjected to Edman microsequencing. The amino acid sequences of the peptides were found to be virtually identical to that of human neuron-specific enolase (NSE). A monoclonal antibody specific for human NSE confirmed the presence of this enzyme in the bovine IPM by both Western blotting and immunocytochemical analysis. Immunofluorescence microscopy demonstrated that NSE is mainly localized to the basal domain of the IPM surrounding photoreceptor cells but is also prominent in the inner segments of the cone photoreceptor neurons. When NSE was added to cultures of human retinoblastoma cells, no effect on morphology was observed. However, a positive effect on cell growth and/or survival was readily apparent. It thus seems that not only is NSE a significant component of the retinal extracellular matrix, but that it could function as a survival (neuronotrophic) factor for photoreceptor neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuron-specific enolase
KW  - retina
KW  - neuron survival factor
KW  - interphotoreceptor matrix
KW  - extracellular matrix
KW  - photoreceptor
KW  - neuron
KW  - neuronotrophic protein
KW  - 1995
KW  - Neurons
KW  - Photoreceptors
KW  - Retina
KW  - Antibodies
KW  - Morphology
KW  - Peptides
KW  - 1995
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105854469
T1  - Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case-control study of cervical neoplasia.
AU  - Wideroff L
AU  - Schiffman MH
AU  - Nonnenmacher B
AU  - Hubbert N
AU  - Kirnbauer R
AU  - Greer CE
AU  - Lowy D
AU  - Lorincz AT
AU  - Manos MM
AU  - Glass AG
Y1  - 1995/01/14/
N1  - Accession Number: 105854469. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675. 
KW  - Antibodies, Viral -- Blood
KW  - Cervix Neoplasms
KW  - Immunoglobulins -- Blood
KW  - Papillomaviruses -- Immunology
KW  - Viruses -- Immunology
KW  - Case Control Studies
KW  - DNA -- Blood
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Female
KW  - Papillomaviruses
KW  - Polymerase Chain Reaction
KW  - Human
SP  - 1425
EP  - 1430
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 172
IS  - 6
PB  - Oxford University Press / USA
SN  - 0022-1899
AD  - Environmental Epidemiology and Biostatistics Branches, National Cancer Institute, Bethesda, MD 20892-7374, USA.
U2  - PMID: 7594698.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854493
T1  - Divergent human papillomavirus type 16 variants are serologically cross-reactive.
AU  - Cheng G
AU  - Icenogle JP
AU  - Kirnbauer R
AU  - Hubbert NL
AU  - St Louis ME
AU  - Han C
AU  - Svare EI
AU  - Kjaer SK
AU  - Lowy DR
AU  - Schiller JT
Y1  - 1995/01/14/
N1  - Accession Number: 105854493. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675. 
KW  - Papillomaviruses -- Immunology
KW  - Antigen-Antibody Reactions
KW  - Female
KW  - Immunoglobulins -- Immunology
KW  - Papillomaviruses -- Classification
KW  - Viruses -- Immunology
SP  - 1584
EP  - 1587
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 172
IS  - 6
PB  - Oxford University Press / USA
SN  - 0022-1899
AD  - Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA.
U2  - PMID: 7594721.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Duverger, Nicolas
AU  - Rader, Daniel
AU  - Ikewaki, Katsunori
AU  - Nishiwaki, Masato
AU  - Sakamoto, Takuya
AU  - Ishikawa, Toshitsugu
AU  - Nagano, Makoto
AU  - Nakamura, Haruo
AU  - Brewer Jr, H. Bryan
T1  - Characteristics of high-density apolipoprotein particles A-I and A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/01/15/
VL  - 227
IS  - 1/2
M3  - Article
SP  - 123
EP  - 129
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The cholesteryl ester transfer protein (CETP) plays an important role in metabolism of high-density lipoprotein and reverse cholesterol transport in humans. The two major classes of high-density lipoprotein particles are those containing apolipoprotein A-I (LpA-I) and those containing both apoA-I and apoA-II (LpA-I:A-II). We isolated and characterized the apoA-I-containing lipoprotein particles from three subjects with homozygous CETP deficiency (CETP-D) and compared the results with those from normolipidemic control subjects. Plasma concentrations of apoA-I in both LpA-I and LpA-I:A-II were significantly elevated in CETP-D subjects. Both LpA-I and LpA-I:A-II from these subjects were larger and contained more cholesteryl ester per particle than control particles. In CETP-D, subpopulations of LpA-I and LpA-I:A-II with an unusually large size (Stokes diameters 13.8 nm and 12.6 nm, respectively) not detected in normal subjects were isolated. The molar ratio of apoA-I to apoA-II in LpA-I :A-II isolated from CETP-D subjects was higher (mean 2,4) than those of controls (mean 1.4). ApoE was primarily associated with LpA-I:A-II in CETP-D subjects. A subclass of LpA-I with pre-β migration on agarose electrophoresis was increased in CETP-D subjects. Both LpA-I and LpA-I:A-II from CETP-D subjects bound with higher affinity but less capacity to HepG2 cells compared with control particles, and were internalized to a lesser extent than control particles. These data suggest that the absence of CETP in humans significantly affects the plasma concentration, size, composition, and cellular interaction of both major classes of apoA-I-containing lipoprotein particles. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APOLIPOPROTEINS
KW  - BLOOD lipoproteins
KW  - HIGH density lipoproteins
KW  - LOW density lipoproteins
KW  - BLOOD cholesterol
KW  - PROTEIN deficiency
KW  - apolipoprotein A I
KW  - apolipoprotein A II
KW  - HepG2 cells
KW  - Immunoaffinity chromatography
N1  - Accession Number: 13506511; Duverger, Nicolas 1 Rader, Daniel 1 Ikewaki, Katsunori 1 Nishiwaki, Masato 2 Sakamoto, Takuya 3 Ishikawa, Toshitsugu 2 Nagano, Makoto 3 Nakamura, Haruo 2 Brewer Jr, H. Bryan 1; Affiliation:  1: Molecular Disease Branch, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda MD, USA  2: First Department of Internal Medicine, National Defense Medical College, Saitama, Japan  3: Department of Internal Medicine, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan; Source Info: 1/15/95, Vol. 227 Issue 1/2, p123; Subject Term: APOLIPOPROTEINS; Subject Term: BLOOD lipoproteins; Subject Term: HIGH density lipoproteins; Subject Term: LOW density lipoproteins; Subject Term: BLOOD cholesterol; Subject Term: PROTEIN deficiency; Author-Supplied Keyword: apolipoprotein A I; Author-Supplied Keyword: apolipoprotein A II; Author-Supplied Keyword: HepG2 cells; Author-Supplied Keyword: Immunoaffinity chromatography; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Boinski, Sue
AU  - Mitchell, Carol L.
T1  - Wild Squirrel Monkey (Saimiri sciureus) "Caregiver" Calls: Contexts and Acoustic Structure.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1995/02//
VL  - 35
IS  - 2
M3  - Article
SP  - 129
EP  - 137
SN  - 02752565
AB  - A field study of the vocal behavior of 22 wild adult female squirrel monkeys (Saimiri sciureus) in Parque Nacional del Manu, Peru, found that 21% of vocalizations were "caregiver" calls. Caregiver calls are brief, low frequency calls, often with numerous harmonics, that are addressed by caregivers to their own infants in three contexts: 1) prenurse, signalling the caregiver's location and willingness to nurse; 2) nurse, while nursing; and 3) end nurse, indicating the end of the nursing bout. Three measures (start, end, and peak frequency) of the acoustic structure of the fundamental frequency of the caregiver calls significantly differed across the contexts. Duration of caregiver calls, however, was not distinguished by context. Compared to other primate taxa, the specificity and importance of caregiver calls in squirrel monkey vocal behavior appears unusual, if not unique. That S. sciureus caregiver calls are highly developed and employed so extensively probably follows from an unusual combination of ecological and life history factors. These factors include delayed weaning and large infant body size, high levels of indirect foraging competition which encourages spatial separation, susceptibility to predation, and specialization on a densely foliated, branch-end microhabitat in which visual contact is often impeded. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SQUIRREL monkeys
KW  - VOCAL cords
KW  - HEARING
KW  - ANIMAL calls
KW  - PARQUE Nacional del Manu (Peru)
KW  - PERU
KW  - maternal behavior
KW  - primate vocal communication
KW  - Saimiri sciureus
N1  - Accession Number: 12317079; Boinski, Sue 1,2 Mitchell, Carol L. 3; Affiliation:  1: Department of Anthropology, University of Florida  2: Laboratory of Comparative Ethology, NICHD, National Institutes of Health  3: Amazon Biodiversity Project; Source Info: 1995, Vol. 35 Issue 2, p129; Subject Term: SQUIRREL monkeys; Subject Term: VOCAL cords; Subject Term: HEARING; Subject Term: ANIMAL calls; Subject Term: PARQUE Nacional del Manu (Peru); Subject Term: PERU; Author-Supplied Keyword: maternal behavior; Author-Supplied Keyword: primate vocal communication; Author-Supplied Keyword: Saimiri sciureus; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Serdula, Mary K.
AU  - Coates, Ralph J.
AU  - Byers, Tim
AU  - Simoes, Eduardo
AU  - Mokdad, Ali H.
AU  - Subar, Amy F.
T1  - Fruit and Vegetable Intake among Adults in 16 States: Results of a Brief Telephone Survey.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/02//
VL  - 85
IS  - 2
M3  - Article
SP  - 236
EP  - 239
PB  - American Public Health Association
SN  - 00900036
AB  - A brief food frequency questionnaire was used to assess daily fruit and vegetable consumption among 23 699 adults in 16 US states sampled in a random-digit dialing telephone survey. Men consumed fewer servings per day (3.3) than did women (3.7). Only 20% of the population consumed the recommended 5 or more daily servings. Intakes varied somewhat by state and were lower among the young and the less educated. Efforts are needed to improve fruit and vegetable consumption among all Americans, especially younger adults and those with lower levels of education. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SURVEYS
KW  - FOOD consumption
KW  - FRUIT
KW  - VEGETABLES
KW  - TELEPHONE surveys
KW  - UNITED States
N1  - Accession Number: 9503131565; Serdula, Mary K. 1 Coates, Ralph J. 1,2 Byers, Tim 1 Simoes, Eduardo 1,2 Mokdad, Ali H. 1 Subar, Amy F. 3; Affiliation:  1: Division of Nutrition, National Center for Chronic Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Ga.  2: Epidemiology Division, Emory School of Public Health, Atlanta  3: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Md.; Source Info: Feb1995, Vol. 85 Issue 2, p236; Subject Term: SURVEYS; Subject Term: FOOD consumption; Subject Term: FRUIT; Subject Term: VEGETABLES; Subject Term: TELEPHONE surveys; Subject Term: UNITED States; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenberg, Morris
AU  - Schoenbach, Carrie
AU  - Schooler, Carmi
AU  - Rosenberg, Florence
T1  - GLOBAL SELF-ESTEEM AND SPECIFIC SELF-ESTEEM: DIFFERENT CONCEPTS, DIFFERENT OUTCOMES.
JO  - American Sociological Review
JF  - American Sociological Review
Y1  - 1995/02//
VL  - 60
IS  - 1
M3  - Article
SP  - 141
EP  - 156
SN  - 00031224
AB  - In this paper, we attempt to shed light on the nature of, relevance of, and relationship between global self-esteem and specific self-esteem. We marshal evidence that the two types of self-esteem may have strikingly different consequences, global self-esteem being more relevant to psychological well-being, and specific self-esteem being more relevant to behavior. We use linear structural equation causal modeling to test this hypothesis for the case of global self-esteem (Rosenberg 1979) and specific (academic) self-esteem. Our findings show that, while global self-esteem is more strongly related to measures of psychological well-being, specific (academic) self-esteem is a much better predictor of school performance. Other findings indicate that the degree to which specific academic self-esteem affects global self-esteem, particularly the positive component of global self-esteem, is a function of how highly academic performance is personally valued. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SELF-esteem
KW  - WELL-being
KW  - BEHAVIOR
KW  - PREDICTION of scholastic success
KW  - PERFORMANCE
KW  - PSYCHOLOGY
N1  - Accession Number: 9502161419; Rosenberg, Morris 1,2 Schoenbach, Carrie 2 Schooler, Carmi 2 Rosenberg, Florence 3,4; Affiliation:  1: Community College of Rhode Island, Newport  2: National Institute of Mental Health  3: Walter Reed Army Institute of Research  4: Uniformed Services University of the Health Sciences; Source Info: Feb95, Vol. 60 Issue 1, p141; Subject Term: SELF-esteem; Subject Term: WELL-being; Subject Term: BEHAVIOR; Subject Term: PREDICTION of scholastic success; Subject Term: PERFORMANCE; Subject Term: PSYCHOLOGY; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Selwitz, Robert H.
AU  - Nowjack-Raymer, Ruth
AU  - Driscoll, William S.
AU  - Shou-Hua Li, William S.
T1  - Evaluation after 4 years of the combined use of fluoride and dental sealants.
JO  - Community Dentistry & Oral Epidemiology
JF  - Community Dentistry & Oral Epidemiology
Y1  - 1995/02//
VL  - 23
IS  - 1
M3  - Article
SP  - 30
EP  - 35
SN  - 03015661
AB  - This study evaluates the caries-preventive potential in permanent teeth of dental sealants when combined with an ongoing, school-based fluoride program. The investigation was designed as a sequential, cross-sectional comparison. Dental caries findings in 1987 for 416 children ages 7-11 and 14-17 who received dental sealants and fluorides were compared with corresponding data derived from 1983 baseline examinations of children who received fluoride therapy only. In addition, sealant retention status was determined. Overall mean DMFS scores in 1987 for children in two age groups combined were 51% lower than in 1983. Also, a surface-specific treatment effect was demonstrated in pit and fissures for both older and younger age groups. The overall proportion of sealants retained on occlusal surfaces of first molars after an average of 2 yr (92%) compared favorably with similar figures cited in the scientific literature. The results of this study suggest that pit and fissure sealants confer additional caries-preventive benefits beyond those of fluoride therapy alone. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTISTRY
KW  - DENTAL caries
KW  - DENTAL pathology
KW  - FLUORIDES
KW  - PIT & fissure sealants (Dentistry)
KW  - DENTAL adhesives
KW  - community dentistry
KW  - dental caries
KW  - dental caries prevention
KW  - fluorides
KW  - pit and fissure sealants
N1  - Accession Number: 12051949; Selwitz, Robert H. 1 Nowjack-Raymer, Ruth 1 Driscoll, William S. 1 Shou-Hua Li, William S. 2; Affiliation:  1: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, Bethesda, Maryland.  2: Statistician, Biometrics Branch, Medication Development Division, National Institute on Drug Abuse, Rockville, Maryland, USA.; Source Info: Feb1995, Vol. 23 Issue 1, p30; Subject Term: DENTISTRY; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: FLUORIDES; Subject Term: PIT & fissure sealants (Dentistry); Subject Term: DENTAL adhesives; Author-Supplied Keyword: community dentistry; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: dental caries prevention; Author-Supplied Keyword: fluorides; Author-Supplied Keyword: pit and fissure sealants; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1600-0528.ep12051949
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Aunger, Robert
T1  - On Ethnography.
JO  - Current Anthropology
JF  - Current Anthropology
Y1  - 1995/02//
VL  - 36
IS  - 1
M3  - Article
SP  - 97
EP  - 130
SN  - 00113204
AB  - There are two basic analytical approaches in social research. The first, using formal methods (e.g., standard statistical analysis), aggregates over the attributes of individual cases to determine the influence of abstract effects on events. This approach, which results in correlations between variables, is unable to provide adequate causal explanations for what happens in particular cases. The interpretive or narrative approach, in contrast, aggregates over events to trace the causal development of a single case. This type of analysis cannot be made reflexive (i.e., cannot account explicitly for the intersubjective nature of data collection procedures in human studies). Thus each method, by itself, is problematic. There have been a number of attempts to combine the two approaches in a single theoretical framework. However, because the constituent approaches are fundamentally different in their ontological and epistemological stances, the proposed reconciliations remain forced. This paper outlines a strategy that sequentially utilizes both approaches, preserving their independent and complementary virtues, while providing formal links that allow the results of one approach to inform use of the other directly. It is hoped that practice of this two-step method will dissipate some of the recent doubts about the value of ethnographic fieldwork. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Current Anthropology is the property of Wenner-Gren Foundation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ETHNOLOGY
KW  - ANTHROPOLOGICAL research
KW  - THEORY of knowledge
KW  - ONTOLOGY
KW  - STATISTICS
KW  - CULTURE
KW  - SOCIAL sciences
KW  - SOCIAL structure
KW  - LANGUAGE & languages
N1  - Accession Number: 9502153046; Aunger, Robert 1; Affiliation:  1: National Institute of Mental Health Postdoctoral Fellow in Culture and Mental Health in the Committee on Human Development, University of Chicago; Source Info: Feb95, Vol. 36 Issue 1, p97; Subject Term: ETHNOLOGY; Subject Term: ANTHROPOLOGICAL research; Subject Term: THEORY of knowledge; Subject Term: ONTOLOGY; Subject Term: STATISTICS; Subject Term: CULTURE; Subject Term: SOCIAL sciences; Subject Term: SOCIAL structure; Subject Term: LANGUAGE & languages; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 34p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107394705
T1  - Recounts of elderly deaths: endorsements for the Patient Self-Determination Act.
AU  - Foley DJ
AU  - Miles TP
AU  - Brock DB
AU  - Phillips C
Y1  - 1995/02//
N1  - Accession Number: 107394705. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: This work was supported by National Institute on Aging Contract no NO1-AG-2-2137. NLM UID: 0375327. 
KW  - Death -- In Old Age
KW  - Patient Autonomy -- Legislation and Jurisprudence -- United States
KW  - Surveys
KW  - Legislation
KW  - United States
KW  - Advance Directives
KW  - Aged
KW  - Funding Source
SP  - 119
EP  - 121
JO  - Gerontologist
JF  - Gerontologist
JA  - GERONTOLOGIST
VL  - 35
IS  - 1
PB  - Oxford University Press / USA
SN  - 0016-9013
AD  - National Institute on Aging, Gateway Building Suite 309, 7201 Wisconsin Ave, Bethesda, MD 20892
U2  - PMID: 7890197.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107428651
T1  - Collection and use of circulating hematopoietic progenitor cells.
AU  - Lee J
AU  - Klein HG
Y1  - 1995/02//1995 Feb
N1  - Accession Number: 107428651. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8709473. 
KW  - Hematopoietic System
KW  - Cell Transplantation
KW  - Stem Cells
KW  - Neoplasms -- Therapy
SP  - 1
EP  - 22
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
JA  - HEMATOL ONCOL CLIN NORTH AM
VL  - 9
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0889-8588
AD  - Department of Transfusion Medicine, Building 10, Room 1C-711, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 7737936.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107428654
T1  - Cellular gene therapy.
AU  - Lee J
AU  - Klein HG
Y1  - 1995/02//1995 Feb
N1  - Accession Number: 107428654. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8709473. 
KW  - Gene Therapy
SP  - 91
EP  - 113
JO  - Hematology/Oncology Clinics of North America
JF  - Hematology/Oncology Clinics of North America
JA  - HEMATOL ONCOL CLIN NORTH AM
VL  - 9
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0889-8588
AD  - Department of Transfusion Medicine, Building 10, Room 1C-711, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 7737946.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107299199
T1  - Recent cancer trends in the United States.
AU  - Devesa SS
AU  - Blot WJ
AU  - Stone BJ
AU  - Miller BA
AU  - Tarone RE
AU  - Fraumeni JF Jr.
Y1  - 1995/02//2/1/95
N1  - Accession Number: 107299199. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Neoplasms -- Epidemiology -- United States
KW  - Female
KW  - Epidemiological Research
KW  - Male
KW  - United States
KW  - Sex Factors
KW  - Age Factors
KW  - Human
SP  - 175
EP  - 181
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 3
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Executive Plaza North, Rm 415, National Institutes of Health, Bethesda, MD 20892-7368
U2  - PMID: 7707404.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kim, Soo-Youl
AU  - Chung, Soo-II
AU  - Yoneda, Kozo
AU  - Steinert, Peter M.
T1  - Expression of Transglutaminase 1 in Human Epidermis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/02//
VL  - 104
IS  - 2
M3  - Article
SP  - 211
EP  - 217
SN  - 0022202X
AB  - To explore the expression and function of the membrane-associated or type I transglutaminase (TGase1) in human epidermis, we have made a new anti-human TGase1 antibody in goats elicited against a purified active recombinant protein expressed in bacteria. By use of Western blotting and immunoprecipitation methods, the antibody reacted with high specificity with only the TGase1 activity of the epidermis and in cultured keratinocytes. By indirect immunofluorescence, the antibody decorated the entire epidermis, including the basal layer, with some potentiation of the granular layer. However, these staining properties are quite different from those of a widely used, commercially available TGase1 monoclonal antibody (termed B.C1), which decorates the granular layers of the epidermis. By Western blotting, it identifies the TGase1 protein band only weakly, but recognizes strongly a group of bands of 15-20 kDa, two of which by amino acid analysis and amino acid sequencing are the small proline-rich (SPR) 1 and SPR2 proteins, also expressed in epidermal and epithelial tissues. Together with a series of blocking experiments with TGase1 proteins and synthetic peptides, these data reveal that the major epitope of the B.C1 antibody most likely resides on the amino-terminus of these two SPR proteins rather than on TGase1. Further studies will now be necessary to determine the role(s) of TGase1 during the different stages of development and differentiation in the epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSGLUTAMINASES
KW  - TRANSFERASES
KW  - EPIDERMIS
KW  - EPITHELIUM
KW  - HUMAN beings
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 12612769; Kim, Soo-Youl 1 Chung, Soo-II 2 Yoneda, Kozo 1,3 Steinert, Peter M. 1; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Laboratory of Cellular Development and Oncogenesis, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.  3: Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan.; Source Info: Feb95, Vol. 104 Issue 2, p211; Subject Term: TRANSGLUTAMINASES; Subject Term: TRANSFERASES; Subject Term: EPIDERMIS; Subject Term: EPITHELIUM; Subject Term: HUMAN beings; Subject Term: IMMUNOGLOBULINS; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12612769
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Blauvelt, Andrew
AU  - Katz, Stephen I.
AU  - Udey, Mark C.
T1  - Human Langerhans Cells Express E-Cadherin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/02//
VL  - 104
IS  - 2
M3  - Article
SP  - 293
EP  - 296
SN  - 0022202X
AB  - Murine Langerhans cells (LC) synthesize and express E-cadherin, a Ca++-dependent homophilic cell adhesion molecule that mediates LC-keratinocyte (KC) binding <em>in vitro. In vivo,</em> E-cadherin expression by LC may promote localization and persistence of LC within the epidermis through LC-KC adhesion, In addition, changes in LC E-cadherin expression or affinity may be an important factor in the egress of LC from the epidermis after exposure to antigen. The aim of the present study was to determine if human LC also express E-cadherin, Suction blister roofs were obtained from normal volunteers and epidermal cell (EC) suspensions were prepared by limited trypsinization in the presence of 1 mM Ca++ EC were then incubated with antibodies to E-cadherin and CD1a or HLA-DR, and examined by two-color analytical flow cytometry or immunofluorescence microscopy. Most (82.9% ± 7.4% [mean ± SD], range 67-89%, n = 7) freshly prepared human LC expressed E-cadherin, as did the majority of KC. The amount of E-cadherin (as determined by mean fluorescence intensity) expressed by LC and KC was similar. Trypsin/EDTA treatment of freshly prepared EC abrogated expression of E-cadherin by LC and KC, whereas E-cadherin was not degraded by trypsin in the presence of Ca++, LC expressed lower levels of E-cadherin after 3 d in culture. Thus, human LC, like murine LC, express the homophilic adhesion molecule E-cadherin, which may be important in establishing and maintaining interactions between LC and KC in mammalian epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - DENDRITIC cells
KW  - HUMAN beings
KW  - CELL adhesion molecules
KW  - CELL adhesion
KW  - EPIDERMIS
KW  - <em>adhesion</em>
KW  - <em>keratinocytes.</em>
N1  - Accession Number: 12612830; Blauvelt, Andrew 1 Katz, Stephen I. 1 Udey, Mark C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Feb95, Vol. 104 Issue 2, p293; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: HUMAN beings; Subject Term: CELL adhesion molecules; Subject Term: CELL adhesion; Subject Term: EPIDERMIS; Author-Supplied Keyword: <em>adhesion</em>; Author-Supplied Keyword: <em>keratinocytes.</em>; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12612830
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Blair, Aaron
AU  - Zahm, Shelia Hoar
T1  - Overinterpretation of Small Numbers in the Dow 2,4-D Cohort Study.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1995/02//
VL  - 37
IS  - 2
M3  - Article
SP  - 126
EP  - 126
SN  - 00961736
N1  - Accession Number: 113380004; Blair, Aaron 1 Zahm, Shelia Hoar 1; Affiliation:  1: National Cancer Institute, Occupational Studies Section, Bethesda, Maryland; Source Info: Feb1995, Vol. 37 Issue 2, p126; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107424751
T1  - Point/counterpoint. PRO: breast cancer prevention on trial.
AU  - Ford LG
Y1  - 1995/02//1995 Feb
N1  - Accession Number: 107424751. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Tamoxifen
KW  - Breast Neoplasms -- Drug Therapy
KW  - Clinical Trials
KW  - Female
SP  - 11
EP  - 12
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 4
IS  - 1
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1059-7115
AD  - Division of Cancer Prevention and Control, EPN 300, National Cancer Institute, 6130 Executive Blvd, MSC 7340, Bethesda, Maryland, 20892-7340
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - McKinney, Cindy E.
AU  - Sidransky, Ellen
AU  - LaMarca, Mary E.
AU  - Riviere, Isabelle
AU  - Holleran, Walter M.
AU  - Martin, Brian M.
AU  - Willemsen, Rob
AU  - Mulligan, Richard C.
AU  - Ginns, Edward I.
T1  - GAUCHER DISEASE: A TALE OF TWO SPECIES.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1995/02//
VL  - 1
IS  - 1
M3  - Article
SP  - 79
EP  - 86
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - Gaucher disease, the result of inherited deficiency of glucocerebrosidase, is the most common lysosomal storage disease. No naturally occurring animal models are available for study of its pathophysiology or the development of new therapeutic strategies such as gene therapy. We describe an approach to gene targeting in embryonic stem cells to "knock out" glucocerebrosidase activity and generate a mouse line having the phenotype of severely affected infants with type 2 Gaucher disease. We also discuss an experiment in gene therapy using lethally irradiated mice that are reconstituted with murine fetal liver hematopoietic cells transduced with retrovirus encoding human glucocerebrosidase. Analyses of these animals show production of active human glucocerebrosidase in lysosomes of macrophages for at least 12 months after transplantation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GAUCHER'S disease
KW  - GENE therapy
KW  - LYSOSOMAL storage diseases
KW  - PHENOTYPE
KW  - HEMATOPOIETIC stem cells
KW  - GENETIC engineering
KW  - THERAPEUTICS
KW  - animal model
KW  - embryonic stem cell
KW  - Gaucher disease
KW  - gene targeting
KW  - glucocerebrosidase deficiency.
KW  - lysosomal storage disorder
N1  - Accession Number: 12390826; McKinney, Cindy E. 1 Sidransky, Ellen 1 LaMarca, Mary E. 1 Riviere, Isabelle 2 Holleran, Walter M. 3 Martin, Brian M. 1 Willemsen, Rob 4 Mulligan, Richard C. 2 Ginns, Edward I. 1; Affiliation:  1: Section on Molecular Neurogenetics, Clinical Neuroscience Branch, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland.  2: Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridg, Massachusetts.  3: Department of Dermatology, University of California School of Medicine and VA Medical Center, San Francisco, California.  4: Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands.; Source Info: 1995, Vol. 1 Issue 1, p79; Subject Term: GAUCHER'S disease; Subject Term: GENE therapy; Subject Term: LYSOSOMAL storage diseases; Subject Term: PHENOTYPE; Subject Term: HEMATOPOIETIC stem cells; Subject Term: GENETIC engineering; Subject Term: THERAPEUTICS; Author-Supplied Keyword: animal model; Author-Supplied Keyword: embryonic stem cell; Author-Supplied Keyword: Gaucher disease; Author-Supplied Keyword: gene targeting; Author-Supplied Keyword: glucocerebrosidase deficiency.; Author-Supplied Keyword: lysosomal storage disorder; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hudson-Taylor, Diana E.
AU  - Dolan, Stephen A.
AU  - Klotz, Francis W.
AU  - Fujioka, Hisashi
AU  - Aikawa, Masamichi
AU  - Koonin, Eugene V.
AU  - Miller, Louis H.
T1  - Plasmodium falciparum protein associated with the invasion junction contains a conserved oxidoreducta:.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995/02//
VL  - 15
IS  - 3
M3  - Article
SP  - 463
EP  - 471
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The merozoite cap protein-1 (MCP-1) of <em>Plasmodium falciparum</em> follows the distribution of the moving Junction during invasion of erythrocytes. We have cloned the gene encoding this protein from a cDNA library using a monoclonal antibody. The protein lacks a signal sequence and has no predicted trans-membrane domains; none of the antisera reacts with the surfaces of intact merozoites, indicating that the cap distribution is submembranous. MCP-1 is divided into three domains. The N-terminal domain includes a 52-amino-acid region that is highly conserved in a large family of bacterial and eukaryotic proteins. Based on the known functions of two proteins of this family and the pattern of amino acid conservation, it is predicted that this domain may possess oxido-reductase activity, since the active cysteine residue of this domain is invariant in all proteins of the family. The other Iwo domains of MCP-1 are not found in any other members of this protein family and may reflect the specific function of MCP-1 in invasion. The middle domain is negatively charged and enriched in glutamate; the <em>C</em>-terminal domain is positively charged and enriched in lysine. By virtue of its positive charge, the <em>C</em>-terminal domain resembles domains in some cytoskeleton-associated proteins and may mediate the interaction of MCP-I with cytoskeleton in <em>Plasmodium</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Proteins
KW  - Plasmodium falciparum
KW  - Erythrocytes
KW  - Monoclonal antibodies
KW  - Cytoskeleton
N1  - Accession Number: 16019014; Hudson-Taylor, Diana E. 1; Dolan, Stephen A. 1; Klotz, Francis W. 2; Fujioka, Hisashi 3; Aikawa, Masamichi 3; Koonin, Eugene V. 4; Miller, Louis H. 1; Affiliations: 1: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 209410, USA; 3: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA; 4: Division of National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Feb1995, Vol. 15 Issue 3, p463; Subject Term: Proteins; Subject Term: Plasmodium falciparum; Subject Term: Erythrocytes; Subject Term: Monoclonal antibodies; Subject Term: Cytoskeleton; Number of Pages: 9p; Illustrations: 7 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 106983076
T1  - Workshop on pediatric AIDS rehabilitation: a summary.
AU  - McCardle P
AU  - Quatrano LA
Y1  - 1995/02//1995 Feb
N1  - Accession Number: 106983076. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9107942. 
KW  - Acquired Immunodeficiency Syndrome -- Rehabilitation -- In Infancy and Childhood
KW  - Seminars and Workshops
KW  - Child
SP  - 14
EP  - 17
JO  - Pediatric AIDS & HIV Infection
JF  - Pediatric AIDS & HIV Infection
JA  - PEDIATR AIDS HIV INFECT
VL  - 6
IS  - 1
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1045-5418
AD  - Health Scientist Administrator, Division of Research Grants, National Center for Medical Rehabilitation Research, National Institute of Child Health and Human Development, National Institutes of Health
U2  - PMID: 11361736.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2004-17627-006
AN  - 2004-17627-006
AU  - Newlin, David B.
T1  - Addiction to Drugs: Where Angels Fear to Tread.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1995/02//
VL  - 40
IS  - 2
SP  - 112
EP  - 113
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
AD  - Newlin, David B., Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD, US
N1  - Accession Number: 2004-17627-006. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Newlin, David B.; National Institute on Drug Abuse, Baltimore, MA, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Drug Addiction; Psychobiology. Minor Descriptor: Government Policy Making; Psychopharmacology. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Goldstein, Avram. Addiction: From Biology to Drug Policy=New York: Freeman, 1994. 321 pp. $22.95; 1994. References Available: Y. Page Count: 2. Issue Publication Date: Feb, 1995. 
AB  - According to the reviewer, this book (see record [rid]1993-98841-000[/rid]) is for everyone. Clinicians, experimental psychologists, and the ubiquitous intelligent layperson will all enjoy and learn from this book. Even experienced drug abuse researchers will find much that they either do not know or have not pursued in its pages. It is well written and understandable without oversimplication or patronization. Avram Goldstein is a distinguished scientist, clinician, and author who brings much to the difficult subject of drug addiction. The reader will be impressed by the breadth of his knowledge and his ability to deal with a subject that some may see as a political minefield. The book is divided into three very different parts. The first part is a delightfully succinct overview of the biology of abused drugs. Goldstein discusses laboratory technique only when necessary for the reader to understand the strengths or limitations of the available data. The second part of the book deals with the unique aspects of each of the seven classes of abused drugs. The book leads naturally to the final section on the implications of neuropharmacology and related fields for public policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - abused drugs
KW  - drug addiction
KW  - biology
KW  - public policy
KW  - neuropharmacology
KW  - 1995
KW  - Drug Abuse
KW  - Drug Addiction
KW  - Psychobiology
KW  - Government Policy Making
KW  - Psychopharmacology
KW  - 1995
U2  - Goldstein, Avram. (1994); Addiction: From Biology to Drug Policy; New York: Freeman, 1994. 321 pp. $22.95; 0-7167-2384-0.
DO  - 10.1037/003390
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Sugiyama, Satoru
AU  - Utani, Atushi
AU  - Yamada, Shumpei
AU  - Kozak, Christine A.
AU  - Yamada, Yoshihiko
T1  - Cloning and expression of the mouse laminin γ2 (B2t) chain, a subunit of epithelial cell laminin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/02/15/
VL  - 228
IS  - 1
M3  - Article
SP  - 120
EP  - 128
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We have isolated and sequenced the full-length cDNA for the mouse laminin γ2 chain and mapped it to mouse Chromosome 1 proximal to laminin γ1. The mRNA for the mouse γ2 spans 5.2 kb and codes for a 1192-residue amino acid polypeptide. The γ2 chain (formerly termed laminin B2t), a homologue of γ1 (formerly B2), lacks an N-terminal domain and has a shorter domain III in comparison to the laminin γ1 chain. The expression of the laminin γ2 and γ1 chains in both newborn and fetal mice was examined by both Northern analysis and in situ hybridization, mRNA for the laminin γ2 chain was expressed specifically by epithelial cells in many tissues with a particularly high level of expression in the tongue, hair follicles, lung and kidney. In contrast, a high level of expression of the laminin γ1 chain mRNA was seen in both epithelial and endothelial cells in these tissues. In addition, γ1 mRNA was expressed in other tissues such as the nasal septum, blood vessels, and the muscle of the tongue. Immunohistuchemistry with an anti-γ2 IgG detected strong expression of the laminin γ2 chain in the basement membrane of the collecting tubules of the kidney and of the pancreas. Immunoprecipitation studies with antibodies to the γ2 chain detected three species at 165, 155 and 140 kDa in HT-1080 cell-conditioned media. This protein complex is characteristic of the kalinin (nicein/epiligrin) complex, and provides further evidence that these proteins are identical and that the γ2 chain is the subunit of the epithelial-cell-specific laminin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENETIC research
KW  - MOLECULAR biology
KW  - GENE expression
KW  - ANIMAL genetics
KW  - CHROMOSOMES -- Analysis
KW  - MICE
KW  - RESEARCH
KW  - IMMUNOCHEMISTRY
KW  - BIOCHEMISTRY
KW  - 2 chain
KW  - cloning
KW  - expression
KW  - mapping
KW  - mouse laminin &gamma
KW  - sequence
N1  - Accession Number: 12010657; Sugiyama, Satoru 1 Utani, Atushi 1 Yamada, Shumpei 1 Kozak, Christine A. 2 Yamada, Yoshihiko 1; Affiliation:  1: The Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA  2: The Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 2/15/95, Vol. 228 Issue 1, p120; Subject Term: GENETIC research; Subject Term: MOLECULAR biology; Subject Term: GENE expression; Subject Term: ANIMAL genetics; Subject Term: CHROMOSOMES -- Analysis; Subject Term: MICE; Subject Term: RESEARCH; Subject Term: IMMUNOCHEMISTRY; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: 2 chain; Author-Supplied Keyword: cloning; Author-Supplied Keyword: expression; Author-Supplied Keyword: mapping; Author-Supplied Keyword: mouse laminin &gamma; Author-Supplied Keyword: sequence; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107379021
T1  - The role of increasing detection in the rising incidence of prostate cancer.
AU  - Potosky AL
AU  - Miller BA
AU  - Albertsen PC
AU  - Kramer BS
AU  - Potosky, A L
AU  - Miller, B A
AU  - Albertsen, P C
AU  - Kramer, B S
Y1  - 1995/02/15/
N1  - Accession Number: 107379021. Language: English. Entry Date: 19960801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Cancer Screening -- Utilization
KW  - Prostatic Neoplasms -- Prevention and Control
KW  - Prostatic Neoplasms -- Epidemiology
KW  - Prostate-Specific Antigen
KW  - Biopsy, Needle -- Utilization
KW  - Ultrasonography -- Utilization
KW  - United States
KW  - Male
KW  - Aged
KW  - Prostatic Neoplasms -- Diagnosis
KW  - Human
SP  - 548
EP  - 552
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 273
IS  - 7
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To assess the reasons for the dramatic surge in prostate cancer incidence from 1986 to 1991.Design: Population-based study of incidence rates and procedures used to detect and diagnose prostate cancer derived from Medicare claims data and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program from 1986 to 1991.Setting: Four SEER areas (Connecticut; Atlanta, Ga; Detroit, Mich; and Seattle--Puget Sound, Wash) covering approximately 6% of the US population.Participants: A 5% random sample of male fee-for-service Medicare beneficiaries aged 65 years and older without cancer, and all men with prostate cancer diagnosed at 65 years of age and older residing in the four areas.Main Outcome Measures: The age-adjusted rates of prostate cancer incidence, prostate needle biopsy, transurethral resection of the prostate, serum prostate-specific antigen (PSA) testing, and transrectal ultrasound.Results: The age-adjusted incidence rate of prostate cancer among men aged 65 years and older in the four SEER areas rose 82% from 1986 to 1991, with the largest annual increases occurring in 1990 (20%) and 1991 (19%). Prostate needle biopsy rates increased while the use of transurethral resection of the prostate declined from 1986 to 1991. The rising needle biopsy rate has been driven by an exponential increase in PSA testing in the general population from 1988 to 1991 and, to a much lesser extent, the increasing use of transrectal ultrasound since 1986. The use of PSA or transrectal ultrasound has increased across age and race groups and in different geographic areas. However, there remain wide geographic variations in the use of PSA screening.Conclusions: The recent dramatic epidemic of prostate cancer is likely the result of the increasing detection of tumors resulting from increased PSA screening. The magnitude and rapidity of the incidence rise suggest that changes in the intensity of medical surveillance is the most plausible explanation for this trend.Implications: The rapid diffusion of screening interventions that have the ability to detect latent asymptomatic disease leads to important concerns regarding costs and patient quality of life for men aged 65 years and older. Geographic variability in the adoption of PSA testing underscores uncertainty and disagreement about its value for reducing prostate cancer mortality. More research is required to determine the effectiveness of screening for prostate cancer.
SN  - 0098-7484
AD  - Applied Research Branch, National Cancer Institute, Bethesda, Md 20892-7344
AD  - Applied Research Branch, National Cancer Institute, 6130 Executive Blvd, EPN Room 313, Bethesda, MD 20892-7344
U2  - PMID: 7530782.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - March-Amegadzie, Roslyn
AU  - Hinton, Deborah M.
T1  - The bacteriophage T4 middle promoter PuvsX: analysis of regions important for binding of the T4 transcriptional activator MotA and for activation of transcription.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995/02/15/
VL  - 15
IS  - 4
M3  - Article
SP  - 649
EP  - 660
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Bacteriophage T4 middle promoters, which are transcribed using phage-modified host RNA polymerase and the T4 transcriptional activator, MotA, match the host σ70 consensus sequence at -10, but they have a different consensus ((t/a)(t/a)TGCTT(t/c)A) (a MotA box) at -30. While the T4 middle promoter Puvsx has these -10 and -30 motifs, it also has matches to the MotA box at -35, -51, -70, and -87. We show that MotA binds to Puvsx DNA, footprinting a region that includes the MotA boxes at -30, -35, and -51. Very high levels of MotA are required for footprinting and gel-shift experiments, and protein-DNA complexes formed in the presence of both phage-modified polymerase and MotA are more resistant to <em>Hin</em>dlll cleavage than those formed with either protein alone. These results suggest that MotA-DNA interactions may be stabilized by phage-modified polymerase. Sequences between -18 and -38 are absolutely required for MotA activation of transcription, but sequences upstream of -38 are stimulatory, particularly when chloride instead of glutamate is the major anion. Our results dissect Puvsx into a core promoter, downstream of -38, which is required for MotA activation, and an upstream region that enhances transcription especially under conditions less favourable for protein-DNA interactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bacteriophage T4
KW  - Promoters (Genetics)
KW  - Genetic transcription
KW  - RNA polymerases
KW  - DNA
N1  - Accession Number: 16064860; March-Amegadzie, Roslyn 1; Hinton, Deborah M. 1; Affiliations: 1: Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 2A-13, Bethesda, Maryland 20892, USA; Issue Info: Feb1995, Vol. 15 Issue 4, p649; Subject Term: Bacteriophage T4; Subject Term: Promoters (Genetics); Subject Term: Genetic transcription; Subject Term: RNA polymerases; Subject Term: DNA; Number of Pages: 12p; Illustrations: 6 Diagrams, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107359675
T1  - Nutrition and metal toxicity.
AU  - Goyer RA
Y1  - 1995/03//
N1  - Accession Number: 107359675. Language: English. Entry Date: 19960201. Revision Date: 20150819. Publication Type: Journal Article; proceedings; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Lead
KW  - Cadmium
KW  - Mercury
KW  - Nutrition
KW  - Anemia, Iron Deficiency
KW  - Calcium -- Metabolism
KW  - Congresses and Conferences -- California
KW  - California
SP  - 646S
EP  - 50S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 61
IS  - 3
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - WC-05, National Institute of Environmental Health Sciences, Research Triange Park, NC 27707
U2  - PMID: 7879732.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107359683
T1  - Long-term fat intake and biomarkers.
AU  - Lands WEM
Y1  - 1995/03//
N1  - Accession Number: 107359683. Language: English. Entry Date: 19960201. Revision Date: 20150819. Publication Type: Journal Article; proceedings. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Dietary Fats
KW  - Biological Markers
KW  - Fatty Acids
KW  - Congresses and Conferences -- California
KW  - California
SP  - 721S
EP  - 5S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 61
IS  - 3
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - WEM Lands, Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, 6000 Executive Boulevard, MSC 7003, Rockville, MD 20892-7003
U2  - PMID: 7879743.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 108016740
T1  - Comparing the Roles of Community-Living Persons and Patient Populations.
AU  - Dickerson, Anne E.
AU  - Oakley, Frances
Y1  - 1995/03//
N1  - Accession Number: 108016740. Language: English. Entry Date: 20130515. Revision Date: 20150712. Publication Type: Journal Article; research. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Role Checklist (Oakley et al). NLM UID: 7705978. 
KW  - Disabled
KW  - Community Living
KW  - Values Clarification
KW  - Role -- Evaluation
KW  - Diagnosis, Psychosocial
KW  - Model of Human Occupation
KW  - Residence Characteristics
KW  - Checklists
KW  - Chi Square Test
KW  - Comparative Studies
KW  - Adult
KW  - Inpatients
KW  - Outpatients
KW  - Human
SP  - 221
EP  - 228
JO  - American Journal of Occupational Therapy
JF  - American Journal of Occupational Therapy
JA  - AM J OCCUP THER
VL  - 49
IS  - 3
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
SN  - 0272-9490
AD  - Assistant Professor, Department of Occupational Therapy, 306D Belk Building, East Carolina University, Greenville, North Carolina 27858
AD  - Clinical Research Program Coordinator, Occupational Therapy Section, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 7741155.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Weindruch, Richard
AU  - Marriott, Bernadette M.
AU  - Conway, Joan
AU  - Knapka, Joseph J.
AU  - Lane, Mark A.
AU  - Cutler, Richard G.
AU  - Roth, George S.
AU  - Ingram, Donald K.
T1  - Measures of Body Size and Growth in Rhesus and Squirrel Monkeys Subjected to Long-Term Dietary Restriction.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1995/03//
VL  - 35
IS  - 3
M3  - Article
SP  - 207
EP  - 228
SN  - 02752565
AB  - Although many studies have reported the robust effects of dietary restriction (DR) in retarding numerous aging processes in rodents, little is known about the outcomes of reducing caloric intake of a nutritious diet on aging in primates. Most primate studies have concerned the effects of malnutrition. We hypothesized that DR influences aging processes in primate species as it does in rodents. In the present study, 24 male rhesus (Macaca mulatta) monkeys (ages 0.6-5 years) and 25 male squirrel (Saimiri sp.) monkeys (ages 0.3-10 years) were provided diets formulated differently for each species but both fortified with vitamins and minerals (40% above recommended levels) as controls (approximating ad libitum levels) or experimentals (about 30% below the level of diet provided controls of comparable age and body weight). The results reported here concern the hypothesis that DR imposed during various developmental stages in these two primate species would affect morphometric parameters obtained at different occasions during the first 5 years of the study. Groups of older monkeys (rhesus: 18-25 years, n = 3; squirrel: 10-15 years, n = 4) were also included as controls for comparative purposes. Among groups of rhesus monkeys begun on DR prior to 6 years of age, growth in body weight and crown-rump length was reduced about 10-20% beginning after 1 year on the diet, with estimated food intake being reduced about 30-35% over this period. Measures of skin-fold thickness and various body circumference measures were also reduced in experimental groups of rhesus monkeys. In contrast, the DR regimen involving a different diet produced little impact on comparable measures in squirrel monkeys, with the estimated food intake being reduced only about 20-25% over this period. However, evidence of divergence in some morphometric parameters in squirrel monkeys was beginning to emerge in young groups (<5 years) after 3 years on the diet. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHESUS monkey
KW  - SQUIRREL monkeys
KW  - BODY size
KW  - GROWTH
KW  - FOOD -- Caloric content
KW  - DIET
KW  - NUTRITION
N1  - Accession Number: 12316679; Weindruch, Richard 1 Marriott, Bernadette M. 2 Conway, Joan 3 Knapka, Joseph J. 4 Lane, Mark A. 5 Cutler, Richard G. 5 Roth, George S. Ingram, Donald K. 3; Affiliation:  1: Department of Medicine, University of Wisconsin School of Medicine and Geriatric Research, Education, and Clinical Center, William Middleton Veterans' Administration Hospital, Madison, Wisconsin  2: Food and Nutrition Board, National Academy of Sciences, Washington, DC  3: Energy and Protein Nutrition Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville  4: National Center for Research Resoruces, National Institutes of Health, Bethesda  5: Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, Maryland; Source Info: 1995, Vol. 35 Issue 3, p207; Subject Term: RHESUS monkey; Subject Term: SQUIRREL monkeys; Subject Term: BODY size; Subject Term: GROWTH; Subject Term: FOOD -- Caloric content; Subject Term: DIET; Subject Term: NUTRITION; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Burton, Lynda C.
AU  - Steinwachs, Donald M.
AU  - German, Pearl S.
AU  - Shapiro, Sam
AU  - Brant, Larry J.
AU  - Richards, Thomas M.
AU  - Clark, Rebecca D.
T1  - Preventive Services for the Elderly: Would Coverage Affect Utilization and Costs Under Medicare?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/03//
VL  - 85
IS  - 3
M3  - Article
SP  - 387
EP  - 391
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study was undertaken to determine whether adding a benefit for preventive services to older Medicare beneficiaries would affect utilization and costs under Medicare. Methods. The demonstration used an experimental design, enrolling 4195 older, community-dwelling Medicare recipients. Medicare claims data for the 2 years in which the preventive visits occurred were compared for the intervention (n = 2105) and control (n = 2090) groups. Monthly allowable charges for Part A and Part B services and number of hospital discharges and ambulatory visits were compared. Results. There were no significant differences in the charges between the groups owing to the intervention, although total charges were somewhat lower for the intervention group even when the cost of the intervention was included. Charges for both groups rose significantly as would be expected for an aging population. A companion paper describes a modest health benefit. Conclusions. There appears to be a modest health benefit with no negative cost impact. This finding gives an early quantitative basis for the discussion of whether to extend Medicare benefits to include a general preventive visit from a primary care clinician. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICARE
KW  - HEALTH insurance reimbursement
KW  - NATIONAL health insurance
KW  - BENEFICIARIES
KW  - EXPERIMENTAL design
KW  - HOSPITALS -- Admission & discharge
N1  - Accession Number: 9504040208; Burton, Lynda C. 1 Steinwachs, Donald M. 1 German, Pearl S. 1 Shapiro, Sam 1 Brant, Larry J. 2 Richards, Thomas M. 1 Clark, Rebecca D. 1; Affiliation:  1: Health Services Research and Development Center, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md.  2: National Institute of Aging, Gerontology Research Center, Baltimore; Source Info: Mar1995, Vol. 85 Issue 3, p387; Subject Term: MEDICARE; Subject Term: HEALTH insurance reimbursement; Subject Term: NATIONAL health insurance; Subject Term: BENEFICIARIES; Subject Term: EXPERIMENTAL design; Subject Term: HOSPITALS -- Admission & discharge; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Overpeck, Mary D.
AU  - Kotch, Jonathan B.
T1  - The Effect of US Children's Access to Care on Medical Attention for Injuries.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/03//
VL  - 85
IS  - 3
M3  - Article
SP  - 402
EP  - 404
PB  - American Public Health Association
SN  - 00900036
AB  - This analysis examined the effect of access to care on nonfatal medically attended injury rates for US children in 1988. Rates of medically attended injury were about the same for children with health insurance and medicated, after adjustment for other characteristics. However, lack of medical care coverage (health insurance or Medicaid) had the effect of decreasing the rates of both total and serious medically attended injury compared with the rates for children with coverage. For children without coverage, as many as 30% of total injuries and 40% of serious injuries may not have ben attended in 1988. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILDREN -- Wounds & injuries
KW  - CHILDREN'S accidents
KW  - CHILD health services
KW  - CHILD care
KW  - HEALTH insurance
KW  - UNITED States
N1  - Accession Number: 9504040212; Overpeck, Mary D. 1 Kotch, Jonathan B. 2; Affiliation:  1: Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, Md.  2: Department of Maternal and Child Health, University of North Carolina, Chapel Hill.; Source Info: Mar1995, Vol. 85 Issue 3, p402; Subject Term: CHILDREN -- Wounds & injuries; Subject Term: CHILDREN'S accidents; Subject Term: CHILD health services; Subject Term: CHILD care; Subject Term: HEALTH insurance; Subject Term: UNITED States; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Gierlowski, Theresa C.
AU  - Ron, Elaine
AU  - Schneider, Arthur B.
T1  - The Accuracy of Siblings' Family History Reports of Thyroid and Other Cancers.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/03//
VL  - 85
IS  - 3
M3  - Letter
SP  - 408
EP  - 409
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented about the accuracy of family history interviews in a population where independent data on cancer in the siblings of interviewees is available.
KW  - LETTERS to the editor
KW  - FAMILY history (Sociology)
N1  - Accession Number: 20699874; Gierlowski, Theresa C. 1 Ron, Elaine 2 Schneider, Arthur B. 1; Affiliation:  1: Michael Reese Hospital, Division of Endocrinology and Metabolism, University of Illinois College of Medicine, Chicago  2: Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Md.; Source Info: Mar1995, Vol. 85 Issue 3, p408; Subject Term: LETTERS to the editor; Subject Term: FAMILY history (Sociology); Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105852521
T1  - Hymenoptera, hypersensitivity, and history: a prologue to current day concepts and practices in the diagnosis, treatment, and prevention of insect sting allergy.
AU  - Cohen SG
AU  - Bianchine PJ
AU  - Cohen, S G
AU  - Bianchine, P J
Y1  - 1995/03//1995 Mar
N1  - Accession Number: 105852521. Language: English. Entry Date: 20080314. Revision Date: 20161118. Publication Type: journal article; biography. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9503580. 
KW  - Hypersensitivity -- History
KW  - Insect Bites and Stings -- History
KW  - Insects -- Immunology
KW  - Animals
KW  - Art
KW  - History
KW  - Hypersensitivity -- Diagnosis
KW  - Hypersensitivity -- Prevention and Control
KW  - Insect Bites and Stings -- Immunology
KW  - Philately -- History
KW  - Benson, R
KW  - Barnard, J
KW  - Loveless Mary
SP  - 198
EP  - 221
JO  - Annals of Allergy, Asthma & Immunology
JF  - Annals of Allergy, Asthma & Immunology
JA  - ANN ALLERGY ASTHMA IMMUNOL
VL  - 74
IS  - 3
CY  - New York, New York
PB  - Elsevier Science
SN  - 1081-1206
AD  - Intramural Research Division, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
AD  - Intramural Research Division, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
U2  - PMID: 7889376.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107423256
T1  - The role and necessity of axillary lymph node dissection in the managemment of stage I or II breast cancer... parts one and two.
AU  - Danforth DN Jr.
AU  - Cady B
Y1  - 1995/03//
N1  - Accession Number: 107423256. Language: English. Entry Date: 19951001. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 9505539. 
KW  - Breast Neoplasms -- Surgery
KW  - Women's Health
KW  - Lymph Node Excision
KW  - Axilla -- Surgery
KW  - Breast Neoplasms -- Diagnosis
KW  - Female
SP  - 116
EP  - 124
JO  - Breast Journal
JF  - Breast Journal
JA  - BREAST J
VL  - 1
IS  - 2
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 1075-122X
AD  - Surgery Branch, National Cancer Institute, Bldg 10, Rm 2B38, Bethesda, MD 20892-1502
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107419383
T1  - The future of neuro-oncology.
AU  - DeVroom HL
Y1  - 1995/03//1995 Mar
N1  - Accession Number: 107419383. Language: English. Entry Date: 19950901. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8912620. 
KW  - Brain Neoplasms -- Therapy
KW  - Oncologic Care -- Trends
KW  - Gene Therapy
KW  - Ganciclovir -- Therapeutic Use
KW  - Immunotherapy
KW  - Oncologic Nursing
KW  - Proteins
SP  - 179
EP  - 183
JO  - Critical Care Nursing Clinics of North America
JF  - Critical Care Nursing Clinics of North America
JA  - CRIT CARE NURS CLIN NORTH AM
VL  - 7
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Treatment options for patients with malignant primary and metastatic lesions to the brain are limited and offer little therapeutic benefit. Despite the use of conventional therapy survival of patients is measured in weeks and months. The use of gene therapy with ganciclovir administration and immunotherapy using targeted protein toxins are two experimental approaches to improving this poor prognosis through regional therapy. (Copyright 1995 W.B. Saunders Company)
SN  - 0899-5885
AD  - National Institutes of Health, NINDS, 10 Center Drive, Building 10, Room 5D37, MSC 1414, Bethesda, MD 20892-1414
U2  - PMID: 7766373.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107926090
T1  - Comparison of Diets of Diabetic and Nondiabetic Women.
AU  - Tomoko Shimakawa
AU  - Herrera-Acena, M. G.
AU  - Colditz, Graham A.
AU  - Manson, Joann E.
AU  - Stamper, Meir J.
AU  - Willett, Walter C.
Y1  - 1995/03//Mar/Apr1995
N1  - Accession Number: 107926090. Language: English. Entry Date: 20131230. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Commentary: Gillespie Sandra J. COMMENTARY. (DIABETES SPECTRUM) Mar/Apr1995; 8 (2): 95-96; Snetselaar Linda. COMMENTARY. (DIABETES SPECTRUM) Mar/Apr1995; 8 (2): 97-98. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Food Frequency Questionnaire (FFQ). Grant Information: This research was supported in part by National Institutes of Health Grants CA-40356 and DK-36798. NLM UID: 8913432. 
KW  - Food Habits
KW  - Diabetes Mellitus, Type 1
KW  - Diabetes Mellitus, Type 2
KW  - Diabetic Diet -- Utilization
KW  - Diet -- Evaluation
KW  - Nutrient Density
KW  - Body Mass Index
KW  - Age of Onset
KW  - Dietary Carbohydrates -- Administration and Dosage
KW  - Dietary Proteins -- Administration and Dosage
KW  - Dietary Fats -- Administration and Dosage
KW  - Clinical Assessment Tools
KW  - Matched Case Control
KW  - Questionnaires
KW  - Descriptive Statistics
KW  - T-Tests
KW  - P-Value
KW  - Middle Age
KW  - Female
KW  - Human
KW  - Funding Source
KW  - Dietary Sucrose -- Administration and Dosage
KW  - American Diabetes Association
SP  - 90
EP  - 95
JO  - Diabetes Spectrum
JF  - Diabetes Spectrum
JA  - DIABETES SPECTRUM
VL  - 8
IS  - 2
CY  - Alexandria, Virginia
PB  - American Diabetes Association
T3  - From research to practice
AB  - Objective: To assess the dietary habits of diabetic women. Research Design and Methods: Participants in the Nurses Health Study, a cohort of 121,700 registered female nurses, were followed since 1976. We compared the usual dietary intakes of women who had been diagnosed with diabetes mellitus by 1980 and age-matched nondiabetic control women; diets of these women were assessed in 1980 and 1984 by a semiquantitative food frequency questionnaire. The study examined 162 IDDM women and 738 NIDDM women. Similar comparisons were made for 429 women who developed NIDDM between 1980 and 1984. Results: Although differences were small, women with IDDM in 1984 and women with NIDDM in 1980 and 1984 consumed less energy from carbohydrates, especially from sucrose, and more energy from protein and fat than did control women. Similar results were also found in 1984 for the 429 women who developed NIDDM between 1980 and 1984. In 1980, energy from nonsucrose carbohydrate was slightly higher in both IDDM and NIDDM women than in the control women. However, in 1984, using a dietary questionnaire designed to assess more complete dietary intake, less consistent results were obtained. Diabetic women tended to avoid desserts and sweets, sugar-containing beverages, and alcoholic beverages but consumed more meat and meat products. Intakes of foods high in complex carbohydrates (e.g., bread, rice, pasta, and potatoes) were similar between diabetic and control women. Conclusions: The results suggest that these diabetic women did not consume the high-carbohydrate, low-fat diets that the American Diabetes Association has been recommending over the past decade.
SN  - 1040-9165
AD  - Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston; Departments of Nutrition, Epidemiology, and Biostatistics, Harvard School of Public Health, Boston, Massachusetts; Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Westerhoff, Hans V.
AU  - Zasloff, Michael
AU  - Rosner, J. Lee
AU  - Hendler, Richard W.
AU  - De Waal, Anthony
AU  - Gomes, Ana Vaz
AU  - Jongsma, Ans P.M.
AU  - Riethorst, Albert
AU  - Juretic, Davor
T1  - Functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/03//3/1/95
VL  - 228
IS  - 2
M3  - Article
SP  - 257
EP  - 264
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Reports on the functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes.  Activity of the peptides in biological functions; Application of synergy to the antimicrobial activity of the peptides; Dissipation of membrane potential in cytochrome oxidase liposomes.
KW  - ESCHERICHIA coli
KW  - ANTI-infective agents
KW  - PEPTIDES
KW  - BINARY control systems
KW  - TUMORS
KW  - LIPOSOMES
N1  - Accession Number: 12138779; Westerhoff, Hans V. 1,2 Zasloff, Michael 3 Rosner, J. Lee 4 Hendler, Richard W. 5 De Waal, Anthony 1 Gomes, Ana Vaz 1 Jongsma, Ans P.M. 1 Riethorst, Albert 1 Juretic, Davor 6; Affiliation:  1: Division of Molecular Biology, Netherlands Cancer Institute/AvL, The Netherlands  2: E. C. Slater Institute, Biocentrum, University of Amsterdam, The Netherlands  3: Departments of Pediatrics and Genetics, Division of Human Genetics, Childrens Hospital of Philadelphia, USA  4: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA  5: Section of Membrane Enzymology, Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, USA  6: Faculty of Natural Sciences and Arts, University of Split, Croatia; Source Info: 3/1/95, Vol. 228 Issue 2, p257; Subject Term: ESCHERICHIA coli; Subject Term: ANTI-infective agents; Subject Term: PEPTIDES; Subject Term: BINARY control systems; Subject Term: TUMORS; Subject Term: LIPOSOMES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Maini, Carlo
AU  - Cioffi, Raffaele
AU  - Tofani, Anna
AU  - Sciuto, Rosa
AU  - Fontana, Maurizio
AU  - Carapella, Carmine
AU  - Crecco, Marcello
T1  - Indium-111 octreotide scintigraphy in neurofibromatosis.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1995/03//
VL  - 22
IS  - 3
M3  - Article
SP  - 201
EP  - 206
SN  - 03406997
N1  - Accession Number: 71146489; Maini, Carlo 1 Cioffi, Raffaele 1 Tofani, Anna 1 Sciuto, Rosa 1 Fontana, Maurizio 2 Carapella, Carmine 2 Crecco, Marcello 3; Affiliation:  1: Nuclear Medicine Department, 'Regina Elena' National Cancer Institute, Rome Italy  2: Neurosurgery Department, 'Regina Elena' National Cancer Institute, Rome Italy  3: Diagnostic Radiology Department, 'Regina Elena' National Cancer Institute, Rome Italy; Source Info: Mar1995, Vol. 22 Issue 3, p201; Number of Pages: 6p; Document Type: Article
L3  - 10.1007/BF01081513
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eckelman, William
T1  - Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1995/03//
VL  - 22
IS  - 3
M3  - Article
SP  - 249
EP  - 263
SN  - 03406997
N1  - Accession Number: 71146480; Eckelman, William 1; Affiliation:  1: PET Department, National Institutes of Health, Bldg 10, Rm 1C495 20892 Rockville USA; Source Info: Mar1995, Vol. 22 Issue 3, p249; Number of Pages: 15p; Document Type: Article
L3  - 10.1007/BF01081522
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=71146480&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107409516
T1  - Case studies as a research model.
AU  - Feigenbaum K
Y1  - 1995/03//1995 Mar-Apr
N1  - Accession Number: 107409516. Language: English. Entry Date: 19950601. Revision Date: 20150819. Publication Type: Journal Article; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8915377. 
KW  - Case Studies
KW  - Research, Nursing
KW  - Zollinger-Ellison Syndrome -- Surgery
KW  - Patient Education
KW  - Anxiety -- Prevention and Control
KW  - Adult
KW  - Inpatients
KW  - Male
SP  - 54
EP  - 56
JO  - Gastroenterology Nursing
JF  - Gastroenterology Nursing
JA  - GASTROENTEROL NURS
VL  - 18
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Nurses in any field have numerous opportunities for research. Nursing research is undertaken to solve specific clinical dilemmas. Case studies may be a reasonable choice for the nurse involved in patient care. Following one subject may be less overwhelming than studying an entire population of subjects. Case studies provide an in-depth look at a single subject over time. The result of this in-depth analysis can be applied to a standard of care in order to improve clinical practice. Case studies may also be the first step toward a larger research project.
SN  - 1042-895X
AD  - National Institutes of Health in Rockville, Maryland
U2  - PMID: 7727570.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107409516&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107361389
T1  - Light and biological rhythms in psychiatry.
AU  - Rosenthal NE
Y1  - 1995/03//
N1  - Accession Number: 107361389. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9417017. 
KW  - Seasonal Affective Disorder -- Therapy
KW  - Light -- Therapeutic Use
KW  - Circadian Rhythm
SP  - 5
EP  - 6
JO  - Harvard Mental Health Letter
JF  - Harvard Mental Health Letter
JA  - HARV MENT HEALTH LETT
VL  - 11
IS  - 9
CY  - Stamford, Connecticut
PB  - Harvard Health Publications
SN  - 1057-5022
AD  - National Institute of Mental Health, Washington, DC
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107361389&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107417354
T1  - Functional performance in people with chronic obstructive pulmonary disease.
AU  - Leidy NK
Y1  - 1995///1995 Spring
N1  - Accession Number: 107417354. Language: English. Entry Date: 19950801. Revision Date: 20150818. Publication Type: Journal Article; review; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Sickness Impact Profile (SIP). NLM UID: 8400753. 
KW  - Pulmonary Disease, Chronic Obstructive -- Physiopathology
KW  - Pulmonary Disease, Chronic Obstructive -- Psychosocial Factors
KW  - Activities of Daily Living
KW  - Research Instruments
KW  - Clinical Nursing Research -- Evaluation
KW  - Multivariate Analysis
KW  - Chronic Disease
KW  - Outcomes (Health Care)
KW  - Health Status Indicators
SP  - 23
EP  - 35
JO  - Image: Journal of Nursing Scholarship
JF  - Image: Journal of Nursing Scholarship
JA  - IMAGE J NURS SCHOLARSH
VL  - 27
IS  - 1
CY  - Indianapolis, Indiana
PB  - Sigma Theta Tau International
AB  - The extent to which individuals with a chronic physical illness perfom their day-to-day activities and maintain the independence and autonomy they desire is both an indicator of adaptation and an important clinical outcome criterion. Yet the concept of functional performance is not well understood. Studies of people with chronic obstructive pulmonary disease (COPD) have attempted to identify physiologic and psychosocial factors that contribute to functioning in this population. These studies have used a melange of terms, including functional status, functional ability, quality of life, and health status interchangeably. They have also employed a variety of instruments to operationalize functional performance and an assortment of predictors to understand the phenomena. Perhaps as a result of this disarray, no attempt has been made to synthesize the literature for nursing research and practice. The purpose of this paper is to summarize the research on functional performance in people with COPD, indicate areas of understanding and quandary, suggest possible flaws, and propose several new directions for practice and research.
SN  - 0743-5150
AD  - Laboratory for the Study of Human Responses to Health and Illness, National Institute of Nursing Research, National Insititutes of Health, Bethesda, Maryland
U2  - PMID: 7721307.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107417354&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107356475
T1  - Improving the health of America's youth: the NHLBI perspective.
AU  - Lenfant C
Y1  - 1995/03//1995 Mar-Apr Suppl
N1  - Accession Number: 107356475. Language: English. Entry Date: 19960101. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 1995 Mar-Apr Suppl. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137. 
KW  - National Institutes of Health (U.S.)
KW  - Health Promotion -- Methods -- United States
KW  - Research
KW  - Health Education
KW  - United States
KW  - Information Resources
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Middle Age
SP  - S6
EP  - 8
JO  - Journal of Health Education
JF  - Journal of Health Education
JA  - J HEALTH EDUC
VL  - 26
IS  - 2
CY  - Reston, Virginia
PB  - American Alliance for Health, Physical Education, Recreation & Dance
SN  - 1055-6699
AD  - National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107356475&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107356478
T1  - Review of behavioral research for cardiopulmonary health: emphasis on youth, gender, and ethnicity.
AU  - Stone EJ
AU  - Baranowski T
AU  - Sallis JF
AU  - Cutler JA
Y1  - 1995/03//1995 Mar-Apr Suppl
N1  - Accession Number: 107356478. Language: English. Entry Date: 19960101. Revision Date: 20150820. Publication Type: Journal Article; research; review; tables/charts. Supplement Title: 1995 Mar-Apr Suppl. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137. 
KW  - Cardiovascular Diseases -- Prevention and Control -- United States
KW  - Adolescent Health
KW  - School Health Services
KW  - Health Promotion
KW  - United States
KW  - Behavioral Research
KW  - National Institutes of Health (U.S.)
KW  - Sex Factors
KW  - Ethnic Groups
KW  - Child
KW  - Adolescence
KW  - Male
KW  - Female
KW  - Human
SP  - S9
EP  - 17
JO  - Journal of Health Education
JF  - Journal of Health Education
JA  - J HEALTH EDUC
VL  - 26
IS  - 2
CY  - Reston, Virginia
PB  - American Alliance for Health, Physical Education, Recreation & Dance
SN  - 1055-6699
AD  - Health Scientist Administrator, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107356478&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854440
T1  - Immunity to onchocerciasis: putative immune persons produce a Th1-like response to Onchocerca volvulus.
AU  - Elson LH
AU  - Calvopiña M
AU  - Paredes W
AU  - Araujo E
AU  - Bradley JE
AU  - Guderian RH
AU  - Nutman TB
Y1  - 1995/03//1995 Mar
N1  - Accession Number: 105854440. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675. 
KW  - Filariasis -- Immunology
KW  - Nematodes -- Immunology
KW  - T Lymphocytes -- Immunology
KW  - Adolescence
KW  - Adult
KW  - Animals
KW  - Female
KW  - Interferons
KW  - Interleukin 2
KW  - Interleukins
KW  - Male
KW  - Middle Age
SP  - 652
EP  - 658
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 171
IS  - 3
PB  - Oxford University Press / USA
SN  - 0022-1899
AD  - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
U2  - PMID: 7876612.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854440&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854441
T1  - Immune responsiveness and the pathogenesis of human onchocerciasis.
AU  - Ottesen EA
Y1  - 1995/03//1995 Mar
N1  - Accession Number: 105854441. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675. 
KW  - Filariasis -- Immunology
KW  - Antibodies
KW  - Antigens -- Blood
KW  - Antigens -- Immunology
KW  - Autoantibodies -- Blood
KW  - Cytokines
KW  - Filariasis -- Etiology
KW  - Lymphocyte Subsets
KW  - Vaccines -- Immunology
SP  - 659
EP  - 671
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 171
IS  - 3
PB  - Oxford University Press / USA
SN  - 0022-1899
AD  - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
U2  - PMID: 7876613.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854441&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Shimizu, Hiroshi
AU  - Masunaga, Takuji
AU  - Ishiko, Akira
AU  - Matsumura, Kunie
AU  - Hashimoto, Takashi
AU  - Nishikawa, Takeji
AU  - Domloge-Hultsch, Nouha
AU  - Lazarova, Zelmira
AU  - Yancey, Kim B.
T1  - Autoantibodies from Patients with Cicatricial Pemphigoid Target Different Sites in Epidermal Basement Membrane.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/03//
VL  - 104
IS  - 3
M3  - Article
SP  - 370
EP  - 373
SN  - 0022202X
AB  - Indirect immunogold electron microscopy studies of cryofixed, freeze-substituted, and post-embedded normal human skin were performed to localize precisely the ultrastructural binding site of circulating autoantibodies from two groups of patients with cicatricial pemphigoid. One group of patients had circulating IgG autoantibodies that bound the dermal side of 1 M NaC1-split skin and immunoprecipitated epiligrin. The other group of patients had circulating IgG autoantibodies directed against the epidermal side of 1 M NaCl-split skin and showed no specific reactivity to any keratinocyte polypeptide by iminunoprecipitation. IgG autoantibodies from all patients with anti-epiligrin cicatricial pemphigoid bound the lowermost aspect of the lamina lucida at its interface with the lamina densa; the greatest staining was seen beneath and beside hemidesinosomes, In contrast, IgG from cicatricial pemphigoid patients whose autoantibodies bound the epidermal side of 1 M NaCl- split skin localized to hemidesmosomes and the junction between hemidesmosoines and the plasma membranes of basal keratinocytes. Although the latter staining pattern is similar to that observed with anti-BPAG2 autoantibodies, sera from our patients with cicatricial pemphigoid did not bind BPAG2 in immunoprecipitation studies of radiolabeled human keratinocyte extracts or show immunoblot reactivity to a fusion protein corresponding to the immunodominant epitope of this polypeptide. These studies demonstrate the following: 1) Autoantibodies from patients with anti-epiligrin cicatricial pemphigoid consistently bind the lower lamina lucida at its interface with the lamina densa; and 2) other patients with the same phenotype may have IgG autoantibodies against yet-unknown epitopes in basal keratinocytes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOANTIBODIES
KW  - EPIDERMIS
KW  - BASAL lamina
KW  - ELECTRON microscopy
KW  - KERATINOCYTES
KW  - BLOOD plasma
KW  - <em>autoimmunity</em>
KW  - <em>bullous diseases</em>
KW  - <em>epiligrin</em>
KW  - <em>ultra-structure</em>
N1  - Accession Number: 12665840; Shimizu, Hiroshi 1 Masunaga, Takuji 1 Ishiko, Akira 1 Matsumura, Kunie 1 Hashimoto, Takashi 1 Nishikawa, Takeji 1 Domloge-Hultsch, Nouha 2 Lazarova, Zelmira 3 Yancey, Kim B. 3; Affiliation:  1: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.  2: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda.  3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1995, Vol. 104 Issue 3, p370; Subject Term: AUTOANTIBODIES; Subject Term: EPIDERMIS; Subject Term: BASAL lamina; Subject Term: ELECTRON microscopy; Subject Term: KERATINOCYTES; Subject Term: BLOOD plasma; Author-Supplied Keyword: <em>autoimmunity</em>; Author-Supplied Keyword: <em>bullous diseases</em>; Author-Supplied Keyword: <em>epiligrin</em>; Author-Supplied Keyword: <em>ultra-structure</em>; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12665840
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Heineman, Ellen F.
AU  - Gao, Yu-Tang
AU  - Dosemeci, Mustafa
AU  - McLaughlin, Joseph K.
T1  - Occupational Risk Factors for Brain Tumors Among Women in Shanghai, China.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1995/03//
VL  - 37
IS  - 3
M3  - Article
SP  - 288
EP  - 293
SN  - 00961736
N1  - Accession Number: 113341933; Heineman, Ellen F. 1 Gao, Yu-Tang 1 Dosemeci, Mustafa 1 McLaughlin, Joseph K. 1; Affiliation:  1: The etiology of brain cancer is not well understood and few studies have evaluated occupational risk factors among women. We evaluated occupation and industry at time of diagnosis for 276 incident primary brain tumor cases among women in Shanghai, China, for the period 1980-1984, identified through the Shanghai Cancer Registry. Standardized incidence ratios (SIRs) and their 95% confidence intervals (CIs) were calculated for all occupations and industries with at least three female cases. SIRs compared observed to expected numbers of cases, based on incidence rates for Shanghai and the number of women in each occupation and industry according to the 1982 census. Statistically significant excesses of brain tumors were seen among grain farmers (SIR = 6.5, 95% CI = 1.3-19.1), rubber workers (SIR = 5.0, 95% CI = 1.6-11.6), and workers in transportation equipment manufacture and repair (SIR = 2.3, 95% CI = 1.1-4.3). Risks among textile spinners and winders were of borderline significance (SIR - 1.7, 95% CI = 1.0-2.8). Elevated but nonsignificant risks of 2.0 or greater were seen among nurses, plastic products workers, sanitation workers, painters, and workers in manufacture of equipment for electrical generation, transmission, and distribution. Results for farmers, rubber workers, and painters are consistent with previously reported excesses among these occupations in men. The increase among nurses is a new finding, although elevated risks have been observed among male medical professionals. Risks were elevated with likely exposure to pesticides, particularly among those thought to have a high probability and a high level of exposure (SIR = 3.6, 95% CI = 1.2-8.5). Address correspondence to: Ellen F. Heineman, PhD, Occupational Studies Section, National Cancer Institute, 6130 Executive Blvd, Room 418, Rockville, MD 20852.; Source Info: Mar1995, Vol. 37 Issue 3, p288; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Doody, Michele Morin
AU  - Mandel, Jack S.
AU  - Boice, John D.
T1  - Employment Practices and Breast Cancer Among Radiologic Technologists.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1995/03//
VL  - 37
IS  - 3
M3  - Article
SP  - 321
EP  - 327
SN  - 00961736
N1  - Accession Number: 113341939; Doody, Michele Morin 1 Mandel, Jack S. 1 Boice, John D. 1; Affiliation:  1: A case-control study of breast cancer and employment practices among female radiologic technologists was conducted. The cohort from which cases and controls were derived included over 105,000 female medical radiation workers certified by the American Registry of Radiologic Technologists during 1926-1980. Breast cancer cases (n = 528) were individually matched to an average of five control subjects (n = 2628) based on year of birth, year of certification, and length of follow-up. Procedures most commonly performed by controls included fluoroscopy (93%), portable radiographs (92%), routine radiographs (92%), multifilm procedures (87%), dental x-rays (46%), radium therapy (31%), orthovoltage (23%), and cobalt-60 (21%). Breast cancer was not significantly increased with occupational experience with any of these procedures. Furthermore, risk was not related to number of years worked with a particular procedure. This study is reassuring in indicating that medical radiation workers are not at substantial risk for developing radiation-induced breast cancer. However, because only surrogate measures of radiation exposure were available, possibility of a small risk cannot be discounted. Ongoing follow-up this cohort for incident cancers will incorporate detailed exposure assessment schemes, providing additional information on effects of long-term low-dose radiation through occupation. Address correspondence to: Michele M. Doody, MS, Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 408, Bethesda, MD 20892.; Source Info: Mar1995, Vol. 37 Issue 3, p321; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morton, William E.
T1  - Major Differences in Breast Cancer Risks Among Occupations.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1995/03//
VL  - 37
IS  - 3
M3  - Article
SP  - 328
EP  - 335
SN  - 00961736
N1  - Accession Number: 113341940; Morton, William E. 1; Affiliation:  1: Breast cancer incidence and mortality measured for the population of a major metropolitan center included 7368 cases and 2357 deaths over 15 years, ascertained according to National Cancer Institute Surveillance, Epidemiology, and End Results program procedures. Occupational risks were estimated with a census-based occupation coding system for cases and deaths, mean annual age-standardized rates, and age-truncated occupation allocation. Data limitations include absence of population frequencies of personal risk factors for breast cancer, occupation designation errors, lack of knowledge about chemical exposures in apparently high-risk occupation, and the possibility that the number of comparisons could produce significant differences by chance. Compared to community-wide reference incidence and mortality rates, significant excess breast cancer risks were identified for housewives, registered nurses, clinical laboratory technicians, schoolteachers, social workers, secretaries and typists, and meat wrappers and cutters. High incidence rates with unremarkable mortality rates were identified for dental hygienists, religious workers, electronic engineering technicians, authors and journalists, restaurant and bar managers, realty and insurance saleswomen, bank tellers and cashiers, telephone operators, canning and bottling workers, chemical and gas handlers, and papermill workers. These findings agree in part with similar reports and will contribute to the generation of hypotheses to be tested by more specific, in-depth studies. Address correspondence to: William E. Morton, MD, DrPH, Department of Public Health and Preventive Medicine, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road (CB-669), Portland, OR 97201.; Source Info: Mar1995, Vol. 37 Issue 3, p328; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cantor, Kenneth P.
AU  - Stewart, Patricia A.
AU  - Brinton, Louise A.
AU  - Dosemeci, Mustafa
T1  - Occupational Exposures and Female Breast Cancer Mortality in the United States.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1995/03//
VL  - 37
IS  - 3
M3  - Article
SP  - 336
EP  - 348
SN  - 00961736
N1  - Accession Number: 113341941; Cantor, Kenneth P. 1 Stewart, Patricia A. 1 Brinton, Louise A. 1 Dosemeci, Mustafa 1; Affiliation:  1: Mortality records from 24 states, gathered from 1984 to 1989 and coded for occupation and industry, were used to develop leads to workplace exposures as possible breast cancer risk factors. A case-control approach was used, with separate analyses for blacks and whites. After excluding homemakers, 33,509 cases and 117,794 controls remained. A job exposure matrix was used to estimate the probability and level of 31 workplace exposures. After adjusting for socioeconomic status, suggestive associations for probability and level of exposure were found for styrene, several organic solvents (methylene chloride, carbon tetrachloride, formaldehyde), and several metals/metal oxides and acid mists. Because of the methodologic limitations of this study, its primary value is in suggesting hypotheses for further evaluation. The findings for styrene, selected solvents, and metals and metal-related exposures deserve additional study. Address correspondence to: Kenneth P. Cantor, PhD, Environmental Epidemiology Branch, National Cancer Institute, 443 Executive Plaza North, Bethesda, MD 20892; Source Info: Mar1995, Vol. 37 Issue 3, p336; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107391544
T1  - Dependence in activities of daily living as a risk factor for fall injury events among older people living in the community.
AU  - Langlois JA
AU  - Smith GS
AU  - Nelson DE
AU  - Sattin RW
AU  - Stevens JA
AU  - DeVito CA
Y1  - 1995/03//3/ 1/1995
N1  - Accession Number: 107391544. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Katz Index of Activities of Daily Living. Grant Information: Support received from the Centers for Disease Control under Cooperative Agreement No. U50/CCU400728 with the Florida Department of Health and Rehabilitative Services, Dade County Public Health Unit, and through a Centers for Disease Control/Association of Schools of Public Health Internship and a Health Research Council of New Zealand Postdoctoral fellowship awarded to Dr. Langlois. NLM UID: 7503062. 
KW  - Accidental Falls -- In Old Age
KW  - Functional Status -- In Old Age
KW  - Activities of Daily Living -- In Old Age
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and Over
KW  - Case Control Studies
KW  - Female
KW  - Male
KW  - Risk Factors
KW  - Funding Source
KW  - Interviews
KW  - Research Instruments
KW  - Odds Ratio
KW  - Logistic Regression
KW  - Human
SP  - 275
EP  - 278
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, Gateway Building, Suite 3C-309, 7201 Wisconsin Ave. Bethesda, MD 20892
U2  - PMID: 7884118.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Morrell, Christopher H.
AU  - Pearson, Jay D.
AU  - Carter, H. Ballentine
AU  - Brant, Larry J.
T1  - Estimating unknown transition times using a piecewise nonlinear mixed-effects model in men with...
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1995/03//
VL  - 90
IS  - 429
M3  - Article
SP  - 45
SN  - 01621459
AB  - It may be clinically useful to know when prostate-specific antigen (PSA) levels first begin to rise rapidly and to determine if the natural history of PSA progression is different in men with locally confined prostate cancers compared to men with metastatic tumors. This article uses a nonlinear mixed-effects model to describe longitudinal changes in PSA in men before their prostate cancers were detected clinically. Repeated measurements of PSA are available for 18 subjects with a diagnosis of prostate cancer based on prostate biopsy. PSA measurements were determined on repeated frozen serum samples collected from subjects with at least 10.0 years and up to 25.6 years of observation before the cancer was detected. A piecewise model is used to describe this data. The model is linear long before the cancer was detected and exponential nearer the time the cancer was detected. The time at which the PSA levels change from linear to exponential PSA progression is unknown but can be estimated by including random terms that allow each subject to have his own transition time. The model also accounts for two groups of patients--those with local or regional cancer and those with advanced cancer or whose cancer has metastasized. Various parameters are allowed to differ between these two groups. By backward elimination of statistically non-significant parameters, a model is found that adequately describes the data. The model represents a situation where local/regional and advanced/metastatic cancers have similar rates of PSA progression, but advanced/metastatic cancers are diagnosed later. Piecewise mixed-effects models may be useful in a variety of research settings where it is necessary to estimate the unknown time of an event. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICS
KW  - CANCER patients
KW  - PROSTATE cancer
KW  - TUMORS -- Growth
KW  - LONGITUDINAL method
KW  - PROSTATE-specific antigen
KW  - NONLINEAR models (Statistics)
KW  - AGING
KW  - Aging
KW  - Longitudinal data
KW  - Random effects
KW  - Tumor growth.
N1  - Accession Number: 9503092134; Morrell, Christopher H. 1; Pearson, Jay D. 2; Carter, H. Ballentine 3; Brant, Larry J. 4; Affiliations: 1: Associate Professor, Mathematical Sciences Department, Loyola College in Maryland, Baltimore, MD 21210.; 2: Senior Staff Fellow, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224.; 3: Associate Professor, Department of Urology, The Johns Hopkins University, Baltimore, MD 21287.; 4: Mathematical Statistician, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224.; Issue Info: Mar1995, Vol. 90 Issue 429, p45; Thesaurus Term: STATISTICS; Subject Term: CANCER patients; Subject Term: PROSTATE cancer; Subject Term: TUMORS -- Growth; Subject Term: LONGITUDINAL method; Subject Term: PROSTATE-specific antigen; Subject Term: NONLINEAR models (Statistics); Subject Term: AGING; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Longitudinal data; Author-Supplied Keyword: Random effects; Author-Supplied Keyword: Tumor growth.; Number of Pages: 9p; Illustrations: 1 Diagram, 5 Charts, 8 Graphs; Document Type: Article; Full Text Word Count: 6589
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Troendle, James F.
T1  - A stepwise resampling method of multiple hypothesis testing.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1995/03//
VL  - 90
IS  - 429
M3  - Article
SP  - 370
SN  - 01621459
AB  - This article introduces a method of multiple hypothesis testing that combines the idea of sequential multiple testing procedures with the structure of resampling methods. The method can be seen as an alternative to the analytic method of Dunnett and Tamhane, which requires a specific distributional form. Resampling incorporates the covariance structure of the data without the need for distributional assumptions. Recent work by Westfall and Young has shown that a step-down resampling method is asymptotically consistent when adjusted p values can be obtained exactly for continuous data. This article shows that in the case of a comparison of two groups on multiple outcomes, those results are generalizable to discrete data where exact adjusted p values are not available. It is shown that the method asymptotically attains the desired level for controlling the experimentwise probability of a type I error. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICAL hypothesis testing
KW  - DATA analysis
KW  - NONPARAMETRIC statistics
KW  - DISTRIBUTION (Probability theory)
KW  - RESAMPLING (Statistics)
KW  - MEASUREMENT errors
KW  - Experimentwise
KW  - P value
KW  - Test statistic
KW  - Type I error.
N1  - Accession Number: 9503092209; Troendle, James F. 1; Affiliations: 1: Staff Fellow, National Institute of Child Health - and Human Development, Bethesda, MD 20892.; Issue Info: Mar1995, Vol. 90 Issue 429, p370; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: DATA analysis; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: DISTRIBUTION (Probability theory); Subject Term: RESAMPLING (Statistics); Subject Term: MEASUREMENT errors; Author-Supplied Keyword: Experimentwise; Author-Supplied Keyword: P value; Author-Supplied Keyword: Test statistic; Author-Supplied Keyword: Type I error.; Number of Pages: 9p; Illustrations: 9 Charts; Document Type: Article; Full Text Word Count: 7317
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Mowatt, Michael R.
AU  - Luján, Hugo D.
AU  - Cotten, David B.
AU  - Bowers, Blair
AU  - Yee, Janet
AU  - Nash, Theodore E.
AU  - Stibbs, Henry H.
T1  - Developmentally regulated expression of a Giardia lamblia cyst wall protein gene.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995/03//
VL  - 15
IS  - 5
M3  - Article
SP  - 955
EP  - 963
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The protozoan <em>Giardia lamblia</em> is an obligate parasite of the mammalian small intestine. We studied the expression of a gene that encodes a protein component of the cyst wall, a complex structure assembled during the differentiation of trophozoites to cysts and which is critical to survival of the parasite outside its mammalian host. Transcripts from the cyst wall protein gene increase more than 100-fold during encystation, reaching a maximum between 5 and 24 hours after induction. Cyst wall protein expression also increases dramatically during encystation, and, prior to its incorporation into the nascent cyst wall, the protein is contained within the encystation-specific vesicles of encysting trophozoites. The sequence of the cloned gene predicts an acidic, leucine-rich polypeptide of Mr 26 000 that contains 5.3 tandemly arranged copies of a degenerate 24-amino-acid repeat. A hydrophobic amino-terminal peptide probably serves as the initial signal that targets this protein to a secretory pathway involving vesicular localization during encystation and, ultimately, secretion to form the cyst wall. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Giardia
KW  - Protozoa
KW  - Genes
KW  - Amino acids
KW  - Molecular genetics
N1  - Accession Number: 16094234; Mowatt, Michael R. 1; Email Address: mrm@helix.nih.gov; Luján, Hugo D. 1; Cotten, David B. 2; Bowers, Blair 3; Yee, Janet 1; Nash, Theodore E. 1; Stibbs, Henry H. 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA; 2: Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, 70118, USA; 3: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA; Issue Info: Mar1995, Vol. 15 Issue 5, p955; Thesaurus Term: Giardia; Thesaurus Term: Protozoa; Subject Term: Genes; Subject Term: Amino acids; Subject Term: Molecular genetics; Number of Pages: 9p; Illustrations: 2 Black and White Photographs, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104780032
T1  - Transdermal clonidine compared to placebo in painful diabetic neuropathy using a two-stage 'enriched enrollment' design.
AU  - Byas-Smith, M G
AU  - Max, M B
AU  - Muir, J
AU  - Kingman, A
Y1  - 1995/03//1995 Mar
N1  - Accession Number: 104780032. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Clonidine -- Administration and Dosage
KW  - Diabetic Neuropathies -- Complications
KW  - Pain -- Drug Therapy
KW  - Administration, Transcutaneous
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Crossover Design
KW  - Double-Blind Studies
KW  - Female
KW  - Prospective Studies
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Pain -- Etiology
KW  - Placebos
KW  - Study Design
SP  - 267
EP  - 274
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 60
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 7596622.
DO  - 10.1016/0304-3959(94)00121-T
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104780032&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Axel Schölmerich, Ellen W.
AU  - Fracasso, Maria P.
AU  - Lamb, Michael E.
AU  - Broberg, Anders G.
T1  - Interactional harmony at 7 and 10 months of age predicts security of attachment as measured by Q-sort ratings.
JO  - Social Development
JF  - Social Development
Y1  - 1995/03//
VL  - 4
IS  - 1
M3  - Article
SP  - 62
EP  - 74
SN  - 0961205X
AB  - Fifty-eight infants and their mothers were observed at home for 45 minutes at seven and ten months of age using a detailed behavioral checklist. During these observations, the degree of mutual interactional engagement was also rated on a 4-point scale every 20 seconds. The attachment security of 38 infants was assessed at 13 months using mothers' reports on the Attachment Q-set (AQS, Waters, 1987). Composite measures of mother-infant interaction derived from the behavioral observations were moderately stable over time. Measures of maternal interactive behaviors and ratings of mutual engagement were highly correlated. Mothers' and infants' behaviors were combined into an index of behavioral harmony that was sensitive to differences in the infants' attachment security three and six months later. Using a stepwise multiple regression, 43% of the variance in the A QS-scores was explained by behavioral harmony at seven months, mutual engagement at 10 months, and infant fuss/cry at seven months. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HARMONY (Aesthetics)
KW  - MOTHERS
KW  - INFANTS
KW  - ENGAGEMENT (Philosophy)
KW  - ATTACHMENT behavior
KW  - Attachment
KW  - Mother-infant interaction
KW  - parental behavior
KW  - Q-sort ratings.
N1  - Accession Number: 11635783; Axel Schölmerich, Ellen W. 1 Fracasso, Maria P. 1 Lamb, Michael E. 1 Broberg, Anders G. 1; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, MD; Source Info: Mar1995, Vol. 4 Issue 1, p62; Subject Term: HARMONY (Aesthetics); Subject Term: MOTHERS; Subject Term: INFANTS; Subject Term: ENGAGEMENT (Philosophy); Subject Term: ATTACHMENT behavior; Author-Supplied Keyword: Attachment; Author-Supplied Keyword: Mother-infant interaction; Author-Supplied Keyword: parental behavior; Author-Supplied Keyword: Q-sort ratings.; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1467-9507.ep11635783
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nee, Linda E.
T1  - Effects of Psychosocial Interactions at a Cellular Level.
JO  - Social Work
JF  - Social Work
Y1  - 1995/03//
VL  - 40
IS  - 2
M3  - Article
SP  - 259
EP  - 262
PB  - Oxford University Press / USA
SN  - 00378046
AB  - Discusses the effects of psychosocial interactions at a cellular level on patients. Social factors and interventions that prolong longevity; Stress; Implications for social work. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL care
KW  - HEALTH
KW  - OLD age
KW  - SOCIAL interaction
KW  - SOCIAL exchange
KW  - SOCIAL services
KW  - UNITED States
KW  - longevity
KW  - physical health
KW  - psychosocial interaction
KW  - stress
N1  - Accession Number: 9503282453; Nee, Linda E. 1; Affiliation:  1: Social science analyst, Family Studies Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.; Source Info: Mar95, Vol. 40 Issue 2, p259; Subject Term: MEDICAL care; Subject Term: HEALTH; Subject Term: OLD age; Subject Term: SOCIAL interaction; Subject Term: SOCIAL exchange; Subject Term: SOCIAL services; Subject Term: UNITED States; Author-Supplied Keyword: longevity; Author-Supplied Keyword: physical health; Author-Supplied Keyword: psychosocial interaction; Author-Supplied Keyword: stress; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 2049
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107417862
T1  - Effects of psychosocial interactions at a cellular level.
AU  - Nee LE
Y1  - 1995/03//
N1  - Accession Number: 107417862. Language: English. Entry Date: 20050425. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 2984852R. 
KW  - Immunity, Cellular -- Psychosocial Factors
KW  - Support, Psychosocial
KW  - Interpersonal Relations
KW  - Social Work
KW  - Longevity
SP  - 259
EP  - 262
JO  - Social Work
JF  - Social Work
JA  - SOC WORK
VL  - 40
IS  - 2
PB  - Oxford University Press / USA
AB  - Psychosocial interactions can affect physiological functions at a cellular level, resulting in increased longevity for people who have had heart attacks or who have acquired immune deficiency syndrome or cancer as well as for healthy individuals. Although social work pioneers and practitioners have always believed that social work intervention can help people feel better, recent studies show that the benefits can be measured quantitatively and qualitatively. In fact, these studies show that lack of psychosocial interaction may be a risk factor for disease progression.
SN  - 0037-8046
AD  - Family Studies Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 7732429.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107417862&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2005-05277-003
AN  - 2005-05277-003
AU  - Prodromidis, Margarita
AU  - Lamb, Michael E.
AU  - Sternberg, Kathleen J.
AU  - Hwang, C. Phillip
AU  - Broberg, Anders G.
T1  - Aggression and Noncompliance among Swedish Children in Centre-based Care, Family Day Care, and Home Care.
JF  - International Journal of Behavioral Development
JO  - International Journal of Behavioral Development
JA  - Int J Behav Dev
Y1  - 1995/03//
VL  - 18
IS  - 1
SP  - 43
EP  - 62
CY  - US
PB  - Lawrence Erlbaum
SN  - 0165-0254
SN  - 1464-0651
AD  - Lamb, Michael E., Section on Social and Emotional Development, NICHD, 9190 Rockville Pike, Bethesda, MD, US, 20814
N1  - Accession Number: 2005-05277-003. Partial author list: First Author & Affiliation: Prodromidis, Margarita; University of Miami School of Medicine, Miami, FL, US. Other Publishers: Elsevier Science, Inc.; Sage Publications; Taylor & Francis. Release Date: 20050531. Correction Date: 20121217. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aggressive Behavior; Child Attitudes; Child Day Care; Family; Home Care. Minor Descriptor: Child Care. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: Sweden. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). Tests & Measures: Belsky and Walker Checklist; Dodge Attribution Inventory; California Child Q-Set; Preschool Behavior Q-Sort DOI: 10.1037/t09940-000; Home Observation for Measurement of the Environment; Child-Rearing Practices Report DOI: 10.1037/t00815-000; Areas of Change Questionnaire DOI: 10.1037/t04809-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Mar, 1995. 
AB  - The relations between individual, family, and child care characteristics and children's aggressive and noncompliant behaviours were examined in this study of 140 first-born Swedish children assessed at 16, 28, 40, and 80 months of age. All of the parents involved in the study had attempted to enrol their children in centre-based day care, but some were accepted instead into family day care settings, while others remained in the exclusive care of their parents. Composite measures of aggression and noncompliance were constructed using data obtained from multiple sources (i.e. mothers, teachers, observers). Child care arrangements and histories were not associated with levels of aggression or noncompliance. Multiple regression analyses suggested that the quality of home care was the best predictor of both aggressive and noncompliant behaviour. Boys were more aggressive than girls, and children with more controlling parents were more noncompliant. Individual differences in aggression (but not noncompliance) were moderately stable over time. Aggression and noncompliance were modestly but reliably related to one another. These results suggest that alternative care of high quality does not lead to noncompliance and aggression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aggressive behavior
KW  - family day care
KW  - home care
KW  - centre based care
KW  - noncompliant behaviors
KW  - child care characteristics
KW  - 1995
KW  - Aggressive Behavior
KW  - Child Attitudes
KW  - Child Day Care
KW  - Family
KW  - Home Care
KW  - Child Care
KW  - 1995
DO  - 10.1177/016502549501800103
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05277-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-05277-004
AN  - 2005-05277-004
AU  - Bornstein, Marc H.
AU  - Maital, Sharone L.
AU  - Tal, Joseph
AU  - Baras, Rebecca
T1  - Mother and Infant Activity and Interaction in Israel and in the United States: A Comparative Study.
JF  - International Journal of Behavioral Development
JO  - International Journal of Behavioral Development
JA  - Int J Behav Dev
Y1  - 1995/03//
VL  - 18
IS  - 1
SP  - 63
EP  - 82
CY  - US
PB  - Lawrence Erlbaum
SN  - 0165-0254
SN  - 1464-0651
AD  - Bornstein, Marc H., Child and Family Research, National Institute of Child Health and Human Development, Building 31-Room B2B15, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2005-05277-004. Partial author list: First Author & Affiliation: Bornstein, Marc H.; National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Elsevier Science, Inc.; Sage Publications; Taylor & Francis. Release Date: 20050531. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Infant Development; Mother Child Relations; Society. Classification: Childrearing & Child Care (2956); Developmental Psychology (2800). Population: Human (10); Female (40). Location: Israel; US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Mar, 1995. 
AB  - Activities and interactions of Israeli and US mothers and their 5-month-old infants were observed in the natural setting of their homes. This report examines infant visual and tactual exploration and vocalisation as well as maternal stimulation and speech. First, similarities and differences in activities between Israeli and US infants and mothers are assessed. Next, coherence in infant activities and in maternal activities within each society are evaluated, and resultant patterns of coherence between the two societies are compared. Last, correspondences between infant and maternal activities in each society are analysed, and resultant patterns of mother-infant interactions between the two societies are compared. Identification and description of activities, interactions, and developmental processes which are similar and different in comparable segments of Israeli and US society are discussed, and cross-cultural tests of developmental issues related to coherence and to correspondence of activity in mother-infant dyads are evaluated. Israeli and US mothers may follow culture-specific paths in striving to meet infants' needs and in achieving socialisation goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mother child relations
KW  - infants
KW  - society
KW  - Israel
KW  - United States
KW  - 1995
KW  - Cross Cultural Differences
KW  - Infant Development
KW  - Mother Child Relations
KW  - Society
KW  - 1995
DO  - 10.1177/016502549501800104
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05277-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-20878-009
AN  - 2004-20878-009
AU  - Bornstein, Marc H.
T1  - Form and Function: Implications for Studies of Culture and Human Development.
JF  - Culture & Psychology
JO  - Culture & Psychology
JA  - Cult Psychol
Y1  - 1995/03//
VL  - 1
IS  - 1
SP  - 123
EP  - 137
CY  - US
PB  - Sage Publications
SN  - 1354-067X
SN  - 1461-7056
AD  - Bornstein, Marc H., Child and Family Research, NICHHD, Building 31--Room B2B15, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2004-20878-009. Partial author list: First Author & Affiliation: Bornstein, Marc H.; Child and Family Research, US National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20041227. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Culture (Anthropological); Human Development; Meaning. Classification: Culture & Ethnology (2930). Population: Human (10). References Available: Y. Page Count: 15. Issue Publication Date: Mar, 1995. 
AB  - Understanding of activity and its meaning is viewed through the prism of context. A given activity often has the same meaning in different contexts, but one activity can also have different meanings across contexts. Conversely, different activities can have different or similar meanings depending on context. A prime context for discussing relations between activity and meaning--that is, between form and function--is culture. Flexible relations between activity and meaning are examined in a unified conceptual scheme, and they are illustrated with phenomena from culture and human development. The heuristic value of this perspective and its implications for studies of culture and human development are also considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - culture
KW  - human development
KW  - activity
KW  - meaning
KW  - 1995
KW  - Culture (Anthropological)
KW  - Human Development
KW  - Meaning
KW  - 1995
DO  - 10.1177/1354067X9511009
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20878-009&site=ehost-live&scope=site
UR  - BR2@NIHCU
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37196-010
AN  - 2015-37196-010
AU  - Smith, Mark A.
AU  - Makino, Shinya
AU  - Kvetnansky, Richard
AU  - Post, Robert M.
T1  - Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/03/01/
VL  - 15
IS  - 3
SP  - 1768
EP  - 1777
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Smith, Mark A., Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N212, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37196-010. PMID: 7891134 Partial author list: First Author & Affiliation: Smith, Mark A.; Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the Society for Neuroscience, 23rd, 1993, Washington, DC, US. Conference Note: These data were presented in part at the aforementioned conference. Major Descriptor: Hippocampus; Rats; Brain Derived Neurotrophic Factor; Neurotrophic Factor; mRNA. Minor Descriptor: Glucocorticoids; Neurons; Stress. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Mar 1, 1995. Publication History: Accepted Date: Sep 1, 1994; Revised Date: Aug 12, 1994; First Submitted Date: Feb 24, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - Chronic stress produces structural changes and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons following stress. To begin investigating this possibility, we examined the effects of immobilization stress (2 hr/d) on the expression of neurotrophic factors in rat brains using in situ hybridization. We found that single or repeated immobilization markedly reduced brain-derived neurotrophic factor (BDNF) mRNA levels in the dentate gyrus and hippocampus. In contrast, NT-3 mRNA levels were increased in the dentate gyrus and hippocampus in response to repeated but not acute stress. Stress did not affect the expression of neurotrophin-4, or tyrosine receptor kinases (trkB or C). Corticosterone negative feedback may have contributed in part to the stress-induced decreases in BDNF mRNA levels, but stress still decreased BDNF in the dentate gyrus in adrenalectomized rats suggesting that additional components of the stress response must also contribute to the observed changes in BDNF. However, corticosterone-mediated increases in NT-3 mRNA expression appeared to be primarily responsible for the effects of stress on NT-3. These findings demonstrate that BDNF and NT-3 are stress-responsive genes and raise the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - stress
KW  - brain-derived neurotrophic factor
KW  - neurotrophin-3
KW  - hippocampus
KW  - glucocorticoids
KW  - plasticity
KW  - 1995
KW  - Hippocampus
KW  - Rats
KW  - Brain Derived Neurotrophic Factor
KW  - Neurotrophic Factor
KW  - mRNA
KW  - Glucocorticoids
KW  - Neurons
KW  - Stress
KW  - 1995
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37196-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37196-012
AN  - 2015-37196-012
AU  - Trapp, Bruce D.
AU  - Kidd, Grahame J.
AU  - Hauer, Peter
AU  - Mulrenin, Eileen
AU  - Haney, Carol A.
AU  - Andrews, S. Brian
T1  - Polarization of myelinating Schwann cell surface membranes: Role of microtubules and the trans-Golgi network.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/03/01/
VL  - 15
IS  - 3
SP  - 1797
EP  - 1807
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Trapp, Bruce D., Department of Neurosciences, Cleveland Clinic Foundation, NC30, 9500 Euclid Avenue, Cleveland, OH, US, 44195
N1  - Accession Number: 2015-37196-012. PMID: 7534340 Partial author list: First Author & Affiliation: Trapp, Bruce D.; Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Globulins; Rats; Spinal Nerves; Schwann Cells; Golgi Apparatus. Minor Descriptor: Myelin Sheath. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Mar 1, 1995. Publication History: Accepted Date: Aug 22, 1994; Revised Date: Aug 15, 1994; First Submitted Date: May 20, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - Schwann cells polarize their surface membranes into several biochemically and ultrastructurally discrete regions of the myelin internode. To form these membrane domains, Schwann cells must sort, transport, and target membrane proteins appropriately. In this study, microtubule disassembly, confocal microscopy, and electron microscopic immunocytochemistry were used to investigate mechanisms involved in targeting P₀ protein (P₀), the myelin-associated glycoprotein (MAG), and laminin to different plasma membrane domains in myelinating Schwann cells from 35-d-old rat sciatic nerve. After microtubule disassembly by colchicine, all three proteins accumulated in Schwann cell perinuclear cytoplasm, indicating that microtubules are necessary for their transport. The distributions of Golgi membranes, endoplasmic reticulum, and intermediate filaments were also altered by colchicine treatment. Electron microscopic immunocytochemical studies indicated that P₀ and MAG are sorted into separate carrier vesicles as they exit the trans-Golgi network. Following microtubule disassembly, P₀-rich carrier vesicles fused and formed myelin-like membrane whorls, whereas MAG-rich carrier vesicles fused and formed mesaxon-like membrane whorls. Microtubule disassembly did not result in mistargeting of either P₀ or MAG to surface membranes. These results indicate that following sorting in the trans-Golgi network, certain carrier vesicles are transported along the myelin internode on microtubules; however, microtubules do not appear to target these vesicles selectively to specific sites. The targeting of P₀-, MAG-, and laminin-rich carrier vesicles to specific sites most likely occurs by ligand receptor binding mechanisms that permit fusion of carrier vesicles only with the appropriate target membrane. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - protein sorting
KW  - protein targeting
KW  - PO protein
KW  - myelinsssociated glycoprotein
KW  - microtubules
KW  - myelination
KW  - 1995
KW  - Globulins
KW  - Rats
KW  - Spinal Nerves
KW  - Schwann Cells
KW  - Golgi Apparatus
KW  - Myelin Sheath
KW  - 1995
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, US. Grant: NS 22849; NS 29818. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37196-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37196-044
AN  - 2015-37196-044
AU  - Niedzielski, Andrew S.
AU  - Wenthold, Robert J.
T1  - Expression of AMPA, kainate, and NMDA receptor subunits in cochlear and vestibular ganglia.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/03/01/
VL  - 15
IS  - 3
SP  - 2338
EP  - 2353
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Niedzielski, Andrew S., Laboratory of Neurochemistry, NIDCD, NIH, Building 36, Room 5D08, Bethesda, MD, US, 20892-4162
N1  - Accession Number: 2015-37196-044. PMID: 7891171 Partial author list: First Author & Affiliation: Niedzielski, Andrew S.; Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Glutamate Receptors; Neurotransmission; Neurotransmitters; Rats; Immunocytochemistry. Minor Descriptor: AMPA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 16. Issue Publication Date: Mar 1, 1995. Publication History: Accepted Date: Sep 29, 1994; Revised Date: Sep 27, 1994; First Submitted Date: Aug 4, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - Glutamate is believed to be the principal afferent neurotransmitter in the peripheral auditory and vestibular systems. In this report, we present a comprehensive molecular analysis of ionotropic glutamate receptor gene expression in the cochlear and vestibular ganglia of the rat. Fourteen glutamate receptor subunits were studied: GluR1-4 (including flip and flop variants), GluR5-7, KA1&2, NR1, and NR2A-D. Reverse transcription of RNA followed by DNA amplification with the polymerase chain reaction was used for the initial analysis. Immunocytochemistry and in situ hybridization with subunit-specific oligonucleotides were subsequently used for cellular localization of receptor expression. AMPA (GluR2-4), kainate (GluR5&6 and KA1&2), and NMDA receptor (NR1 and NR2A-D) subunit expression was detected. Based on the relative amounts of mRNA detected by in situ hybridization, the predominant receptors expressed by cochlear and vestibular ganglion cells appear to be GluR2, GluR3, GluR4, GluR5, and NR1. At a moderate level were GluR6, NR2B, and NR2D. KA1, KA2, NR2A, and NR2C mRNAs were also expressed in ganglion cells, but at lower levels. Only the AMPA receptor subunit GluR1 and the kainate receptor subunit GluR7 were not found to be expressed in vestibulocochlear neurons. These studies suggest that functional AMPA, kainate, and NMDA receptors are present at the hair cell/vestibulocochlear nerve synapse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptor
KW  - in situ hybridization
KW  - immunocytochemistry
KW  - auditory periphery
KW  - hair cc/J
KW  - rat
KW  - 1995
KW  - Glutamate Receptors
KW  - Neurotransmission
KW  - Neurotransmitters
KW  - Rats
KW  - Immunocytochemistry
KW  - AMPA
KW  - 1995
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37196-044&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37196-056
AN  - 2015-37196-056
AU  - Mayat, Ebrahim
AU  - Petralia, Ronald S.
AU  - Wang, Ya-Xian
AU  - Wenthold, Robert J.
T1  - Immunoprecipitation, immunoblotting, and immunocytochemistry studies suggest that glutamate receptor δ subunits form novel postsynaptic receptor complexes.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/03/01/
VL  - 15
IS  - 3
SP  - 2533
EP  - 2546
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mayat, Ebrahim, Laboratory of Neurochemistry, NIDCD, NIH, Building 36, Room 5D-08, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37196-056. PMID: 7891187 Partial author list: First Author & Affiliation: Mayat, Ebrahim; Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebellum; Glutamate Receptors; Rats; Immunocytochemistry. Minor Descriptor: Brain. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: Mar 1, 1995. Publication History: Accepted Date: Oct 12, 1994; Revised Date: Sep 28, 1994; First Submitted Date: Jul 11, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - An antibody was made to a C-terminus peptide of the glutamate receptor δ2 subunit and used to study the distribution, biochemical properties, and developmental expression of the δ receptor in rat brain. The antibody recognizes both δ1 and δ2 but not AMPA, kainate, NMDA, and mGluR1 α glutamate receptor subunits based on Western blot analysis of transfected HEK-293 cells. Western blot analysis of brain showed a single immunoreactive band, migrating at Mr = 114,000. Immunoprecipitation of detergent-solubilized cerebellar membranes was done to determine if δ is associated with other glutamate receptor subunits and if it binds any of the common excitatory amino acid ligands. Based on results of these studies, AMPA, kainate, NMDA, and mGluR1 α subunits do not coassemble with δ subunits, and ³H-glutamate, ³H-AMPA and ³H-kainate do not bind to the δ receptor complex. Western blot and immunocytochemical analyses showed marked expression of δ in the cerebellum while lower levels were detected in other regions of the brain. A dramatic increase of δ 1/2 immunoreactivity was observed in the cerebellum between the ages of 10 and 15 d postnatal. Light and electron microscopy, respectively, demonstrated dense immunostaining in Purkinje cells and in postsynaptic densities of the adult parallel fiber-Purkinje spine synapse. The prominent δ 1/2 immunoreactivity found in the parallel fiber-Purkinje spine synapse, and the temporal correlation of the development of this synapse with the major increase in δ 1/2 immunoreactivity, suggest a major functional role for the δ subunits in cerebellar circuitry. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - ligand binding
KW  - Purkinje cells
KW  - parallel fibers
KW  - cerebellum
KW  - long-term depression
KW  - metabotropic glutamate receptors
KW  - 1995
KW  - Cerebellum
KW  - Glutamate Receptors
KW  - Rats
KW  - Immunocytochemistry
KW  - Brain
KW  - 1995
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37196-056&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37196-057
AN  - 2015-37196-057
AU  - Ma, Wu
AU  - Barker, Jeffery L.
T1  - Complementary expressions of transcripts encoding GAD₆₇ and GABAA receptor α4, β1, and γ1 subunits in the proliferative zone of the embryonic rat central nervous system.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/03/01/
VL  - 15
IS  - 3
SP  - 2547
EP  - 2560
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ma, Wu, Laboratory of Neurophysiologv, NINDS, NIH, Building 36/Roam 2C-02, 9000 Rockville Pike, Bethesda, MD, US, 50892
N1  - Accession Number: 2015-37196-057. PMID: 7891188 Partial author list: First Author & Affiliation: Ma, Wu; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Gamma Aminobutyric Acid; Lumbar Spinal Cord; Neural Receptors; Rats. Minor Descriptor: Decarboxylases; Embryo. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: Mar 1, 1995. Publication History: Accepted Date: Oct 3, 1994; Revised Date: Sep 28, 1994; First Submitted Date: Jul 29, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - The developmental stage at which nerve cells initially express specific neurotransmitters and their corresponding receptors remains elusive. In the present study, the distribution patterns of transcripts for the GABA-synthesizing enzyme, glutamate decarboxylase (GAD₆₇), and specific GABAA receptor subunits were examined in the proliferative zone of the rat central nervous system using in situ hybridization. In order to define the DNA synthetic zone of the germinal matrix, tissue sections were taken from embryos whose mothers had been injected with 5-bromo-2'-deoxyuridine (BrdU) and had survived for 1 hr. BrdU immunocytochemistry was used to locate the relative position of BrdU-immunoreactive nuclei within the ventricular zone (VZ). At embryonic day (E) 15 in the alar plate of the lumbar spinal cord, and at E17 and E20 in the dorsomedial sector of the neocortex, densely packed BrdU-immunoreactive nuclei were consistently detected in lateral portions of the inner half of the germinal matrix, indicating that the inner half of the germinal matrix corresponded to the VZ, while the outer half corresponded to the transitional (TZ) or subventricular zone (SV). In situ hybridization in tissue sections adjacent to BrdU-immunoreacted ones showed that the transcripts for GABAA receptor α3, β3, and γ2 subunits were found exclusively in the mantle zone, while those for α4, β1, and γ1 subunits were predominantly detected in the inner half of the germinal matrix (i.e., VZ). Furthermore, in the E15 germinal matrix of the lumbar spinal cord, cells exhibiting α4 subunit mRNA were much more abundant in the receding intermediate plate, which contains mostly postmitotic cells, than in the alar plate comprised of many DNA-synthesizing cells, strongly suggesting that only those cells completing final cell division expressed the subunit mRNAs. In clear contrast, GAD₆₇ mRNA was abundant in the outer half of the germinal matrix (i.e., TZ or SV), and in the intermediate zone as well. Immunocytochemical staining of E17 neocortex with antiGABA antibody revealed a well defined band of GABA-immunoreactive cells and processes in the SV and occasional positive cells in the VZ. It appears that cells in the proliferative zone may express GABA at the migratory stage, whereas cells in the VZ may express mRNAs for GABAA receptor α4, β1, and γ1 subunits at the premigratory stage, just after completing cell division. The present study suggests that both GABA and GABAA, receptors may be expressed in cells before they migrate to their final positions, and that GABAergic interaction may regulate neuronal migration and differentiation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - development
KW  - germinal matrix
KW  - BrdU immunocytochemistry
KW  - cell cycle
KW  - glutamate decarboxylase
KW  - GABA
KW  - receptor subunits
KW  - in situ hybridization
KW  - 1995
KW  - Central Nervous System
KW  - Gamma Aminobutyric Acid
KW  - Lumbar Spinal Cord
KW  - Neural Receptors
KW  - Rats
KW  - Decarboxylases
KW  - Embryo
KW  - 1995
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37196-057&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Steele, Vernon E.
AU  - Pereira, Michael A.
AU  - Sigman, Caroline C.
AU  - Kelloff, Gary J.
T1  - Cancer Chemoprevention Agent Development Strategies for Genistein.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1995/03/02/Mar95 Supplement
VL  - 125
M3  - Article
SP  - 713S
EP  - 716S
SN  - 00223166
AB  - Cancer chemoprevention refers to the reduction of cancer incidence by administration of agents or drugs that inhibit, reverse or retard the cancer process. Genistein has demonstrated a wide variety of biological activities that make it a good candidate for a chemopreventive agent. Many agents, such as genistein, are currently being tested with the goal of developing safe and effective chemopreventive drugs for human use. Genistein was investigated as a potential chemopreventive agent in an azoxymethane-induced colon carcinogenesis model. Genistein was tested for its ability to inhibit aberrant colon crypts in the colon of F344 rats that had been treated with azoxymethane. Genistein was administered in the diet from 1 wk before the carcinogen to 4 wk after the first carcinogen dose for a total of 5 wk. At both doses, 75 and 150 mg/kg, the mean number of loci per colon was significantly reduced. Further development of this agent includes demonstration of the preventive efficacy in an in vivo tumorigenesis model, followed by preclinical pharmacology and toxicology testing. Phase 1, 2 and 3 clinical chemoprevention trials would be then performed to determine pharmacokinetics, safe doses, and effectiveness for New Drug Approval. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER prevention
KW  - CHEMOPREVENTION
KW  - PREVENTIVE medicine
KW  - DRUG development
KW  - ADMINISTRATION of drugs
KW  - PHARMACOLOGY
KW  - CARCINOGENESIS
KW  - SOYBEAN products
KW  - SOY proteins
KW  - ISOFLAVONES
KW  - cancer prevention
KW  - carcinogenesis
KW  - chemoprevention
KW  - drug development
KW  - genistein
N1  - Accession Number: 22569265; Steele, Vernon E. 1 Pereira, Michael A. 2 Sigman, Caroline C. 3 Kelloff, Gary J. 1; Affiliation:  1: Chemoprevention Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892  2: Department of Pathology, Medical College of Ohio, 3000 Arlington Avenue, Toledo, Ohio 43614  3: CCS Associates, 1965 Landings Drive, Mountain View, CA 94043; Source Info: Mar95 Supplement, Vol. 125, p713S; Subject Term: CANCER prevention; Subject Term: CHEMOPREVENTION; Subject Term: PREVENTIVE medicine; Subject Term: DRUG development; Subject Term: ADMINISTRATION of drugs; Subject Term: PHARMACOLOGY; Subject Term: CARCINOGENESIS; Subject Term: SOYBEAN products; Subject Term: SOY proteins; Subject Term: ISOFLAVONES; Author-Supplied Keyword: cancer prevention; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: chemoprevention; Author-Supplied Keyword: drug development; Author-Supplied Keyword: genistein; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107273852
T1  - Prospects for pharmacotherapy of schizophrenia.
AU  - Pickar D
Y1  - 1995/03/04/
N1  - Accession Number: 107273852. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - Antipsychotic Agents -- Therapeutic Use
KW  - Schizophrenia -- Drug Therapy
KW  - Antipsychotic Agents -- Pharmacodynamics
KW  - Antipsychotic Agents -- Adverse Effects
KW  - Receptors, Drug
KW  - Clozapine -- Therapeutic Use
SP  - 557
EP  - 562
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 345 North American Edition
IS  - 8949
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Experimental Therapeutics Branch, National Institute of Mental Health, NIH Bldg 10/4N212, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 7539875.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107273852&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Boguski, Mark S.
T1  - Adventures in Information Space.
JO  - Serials Librarian
JF  - Serials Librarian
Y1  - 1995/03/10/
VL  - 25
IS  - 3-4
M3  - Article
SP  - 125
EP  - 131
SN  - 0361526X
AB  - Since the mid-1970s, DNA and protein sequence data has led to remarkable discoveries that are revealing the fundamental causes of cancer and genetic disease. By the year 2005, the Human Genome Project will produce a complete blueprint of human biology. Scientists and physicians access these data in GenBank®, a NIH database developed, maintained and distributed by the NCBI. These sequences are linked directly to molecular structure databases and to the biomedical journal literature through bibliographic databases like MEDLINE®. This new knowledge management system functions with the use of e-mail, CD-ROM products, and Internet client-server applications, and blends the world of print publishing with primary source data residing in globally accessible databanks. Current systems require that human beings initiate specific search, analysis, and retrieval requests. However, software robots already maintain and update these data, and "intelligent agents" will soon be available for the automated and targeted dissemination of new research findings. This paper discusses the development of this new working model and speculates about the impact of future technological advances, the effect on how researchers and physicians work, and possible applicability to other research disciplines. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Serials Librarian is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 75421752; Boguski, Mark S. 1; Affiliation:  1: Investigator, National Center for Biotechnology Information, National Library of Medicine; and Acting Director of Bioformatics, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD; Source Info: Mar1995, Vol. 25 Issue 3-4, p125; Number of Pages: 7p; Document Type: Article
L3  - 10.1300/J123v25n03_15
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=75421752&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107379055
T1  - The sensitive heart. A syndrome of abnormal cardiac pain perception.
AU  - Cannon RO III
AU  - Cannon, R O 3rd
Y1  - 1995/03/15/
N1  - Accession Number: 107379055. Language: English. Entry Date: 19960801. Revision Date: 20161112. Publication Type: journal article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Chest Pain
KW  - Angina Pectoris -- Diagnosis
KW  - Syndrome
KW  - Imipramine -- Therapeutic Use
KW  - National Institutes of Health (U.S.)
KW  - United States
KW  - Chronic Disease
KW  - Diagnosis, Differential
KW  - Female
KW  - Middle Age
SP  - 883
EP  - 887
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 273
IS  - 11
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
AD  - Cardiology Branch, Bldg 10, Room 7B-15, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 7869561.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107379055&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Byrne, Gayle
AU  - Suomi, Stephen J.
T1  - Development of Activity Patterns, Social lnteractions, and Exploratory Behavior in Infant Tufted Capuchins (Cebus apella).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1995/04//
VL  - 35
IS  - 4
M3  - Article
SP  - 255
EP  - 270
SN  - 02752565
AB  - Early organization of activity states was studied in 17 tufted capuchin (Cebus apella) infants from birth to 11 weeks of age. Development of exploration and interactions with mothers and other group members were studied in 14 of these infants up to the age of 1 year. Activity profiles changed from 3 to S weeks as infants began to move off mothers and explore their environments. From 2 to 6 months time with mothers de- creased; time alone increased correspondingly. Time spent with other group members did not vary significantly over the first year. By 7-9 months capuchin infants spent more time atone or with other group member than with mothers, although weaning was still not completed by the end of the first year. Simple environmental exploration began in the 2nd month and reached stable levels by 4 months. Complex manipulation of food and objects first began at 3-4 months and increased to stable levels in the second half of the first year. Some preliminary differences were evident between infants living in indoor cages and those living in indoor/ outdoor runs. Infants in cages spent less time in dorsal contact with mothers, and less time in social play and proximity to other animals than those in runs. Instead, infants in cages spent more time alone and engaged in more manipulation of food. Some measures of social and exploratory behavior showed a high degree of variability which may be useful in exploring individual differences in infant temperament or reactivity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL interaction
KW  - CURIOSITY
KW  - ANIMAL young -- Weaning
KW  - FEEDING behavior in animals
KW  - MANIPULATIVE behavior
KW  - PARENTAL behavior in animals
KW  - CAPUCHIN monkeys
KW  - activity
KW  - capuchin
KW  - Cebus
KW  - development
KW  - social behavior.
N1  - Accession Number: 12363461; Byrne, Gayle 1 Suomi, Stephen J. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolesville, Maryland.; Source Info: 1995, Vol. 35 Issue 4, p255; Subject Term: SOCIAL interaction; Subject Term: CURIOSITY; Subject Term: ANIMAL young -- Weaning; Subject Term: FEEDING behavior in animals; Subject Term: MANIPULATIVE behavior; Subject Term: PARENTAL behavior in animals; Subject Term: CAPUCHIN monkeys; Author-Supplied Keyword: activity; Author-Supplied Keyword: capuchin; Author-Supplied Keyword: Cebus; Author-Supplied Keyword: development; Author-Supplied Keyword: social behavior.; NAICS/Industry Codes: 311119 Other Animal Food Manufacturing; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
T1  - Current Perspectives in Primate Laterality.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1995/04//
VL  - 35
IS  - 4
M3  - Book Review
SP  - 327
EP  - 330
SN  - 02752565
AB  - Reviews the book "Primate Laterality: Current Behavioral Evidence of Primate Asymmetries," edited by Jeannette P.Ward and William D.Hopkins.
KW  - ANIMAL behavior
KW  - NONFICTION
KW  - WARD, Jeannette P.
KW  - HOPKINS, William D.
KW  - PRIMATE Laterality: Current Behavioral Evidence of Primate Asymmetries (Book)
N1  - Accession Number: 12363554; Westergaard, Gregory Charles 1; Affiliation:  1: Laboratory of Comparative Ethology National Institute of Child Health and Human Development Poolesville, Maryland.; Source Info: 1995, Vol. 35 Issue 4, p327; Subject Term: ANIMAL behavior; Subject Term: NONFICTION; Reviews & Products: PRIMATE Laterality: Current Behavioral Evidence of Primate Asymmetries (Book); People: WARD, Jeannette P.; People: HOPKINS, William D.; Number of Pages: 4p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gladen, Beth C.
AU  - Rogan, Walter J.
T1  - DDE and Shortened Duration of Lactation in a Northern Mexican Town.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/04//
VL  - 85
IS  - 4
M3  - Article
SP  - 504
EP  - 508
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Worldwide declines in the duration of lactation are cause for public health concern. Higher levels of dichlorodiphenyl dichloroethene (DDE) have been associated with shorter durations of lactation in the United States. This study examined whether this relationship would hold in an agricultural town in northern Mexico. Methods. Two hundred twenty-nine women were followed every-2 months from childbirth until weaning or until the child reached 18 months of age. DDE was measured in breast milk samples taken at birth, and women were followed to see how long they lactated. Results. Median duration was 7.5 months in the lowest DDE group and 3 months in the highest. The effect was confined to those who had lactated previously, and it persisted after statistical adjustment for other factors. These results are not due to overtly sick children being weaned earlier. Previous lactation lowers DDE levels, which produces an artifactual association, but simulations using best estimates show that an effect as large as that found here would arise through this mechanism only 6% of the time. Conclusions. DDE may affect women's ability to lactate. This exposure may be contributing to lactation failure throughout the world. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LACTATION
KW  - PUBLIC health
KW  - DICHLOROETHYLENE
KW  - CHILDBIRTH
KW  - BREAST milk
KW  - MEXICO
N1  - Accession Number: 9504260427; Gladen, Beth C. 1 Rogan, Walter J. 2; Affiliation:  1: Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.  2: Office of the Scientific Director, National Institute of Environmental Health Sciences, Research Triangle Park, NC.; Source Info: Apr95, Vol. 85 Issue 4, p504; Subject Term: LACTATION; Subject Term: PUBLIC health; Subject Term: DICHLOROETHYLENE; Subject Term: CHILDBIRTH; Subject Term: BREAST milk; Subject Term: MEXICO; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Harel, Yossi
AU  - Overpeck, Mary D.
AU  - Jones, Diane H.
AU  - Scheidt, Peter C.
AU  - Bijur, Polly E.
AU  - Trumble, Ann C.
AU  - Hendershot, Gerry E.
T1  - The Quality of Proxy-Respondent Data in NCHS Surveys.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/04//
VL  - 85
IS  - 4
M3  - Letter
SP  - 591
EP  - 592
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented about the quality of proxy-respondent data in the National Center for Health Statistics surveys.
KW  - LETTERS to the editor
KW  - MEDICAL statistics
N1  - Accession Number: 20700177; Harel, Yossi 1 Overpeck, Mary D. 2 Jones, Diane H. 3 Scheidt, Peter C. 4 Bijur, Polly E. 5 Trumble, Ann C. 2 Hendershot, Gerry E. 6; Affiliation:  1: Medical Sociology Program, Bar Ilan University, Ramat Gan, Israel  2: National Institute of Child Health and Human Development, Bethesda, Md.  3: Centers for Disease Control and Prevention, Atlanta, Ga.  4: National Children's Medical Center, Washington, DC.  5: Albert Einstein College of Medicine, Bronx, NY.  6: National Center for Health Statistics, Hyattsvllle, Md.; Source Info: Apr95, Vol. 85 Issue 4, p591; Subject Term: LETTERS to the editor; Subject Term: MEDICAL statistics; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107305641
T1  - Comparison of body size measurements as predictors of NIDDM in Pima Indians.
AU  - Warne DK
AU  - Charles MA
AU  - Hanson RL
AU  - Jacobsson LTH
AU  - McCance DR
AU  - Knowler WC
AU  - Pettitt DJ
Y1  - 1995/04//
N1  - Accession Number: 107305641. Language: English. Entry Date: 19970101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Body Constitution
KW  - Body Mass Index
KW  - Diabetes Mellitus, Type 2 -- Ethnology
KW  - Native Americans -- South America
KW  - South America
KW  - Adolescence
KW  - Adult
KW  - Arizona
KW  - Diabetes Mellitus, Type 2 -- Etiology
KW  - Female
KW  - Male
KW  - Cox Proportional Hazards Model
KW  - Risk Factors
KW  - Human
SP  - 435
EP  - 439
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 18
IS  - 4
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE--To determine and compare the abilities of various anthropometric measurements to predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indian men and women. RESEARCH DESIGN AND METHODS--A total of 290 male and 443 female Pima Indians were followed for up to 6 years for the development of NIDDM. A proportional hazards analysis was used to assess the ability of anthropometric measurements evaluated at baseline to predict NIDDM. Receiver operating characteristic (ROC) curves were used to compare individual variables in predicting NIDDM. RESULTS--In separate models controlled for age and sex, body mass index (BMI), waist circumference, thigh circumference, waist-to-thigh ratio (WTR), weight, and percentage body fat (PBF) estimated by bioelectric resistance each predicted NIDDM, which developed in 30 men and 52 women. The highest incidence rate ratios (IRRs; for 1 SD of a variable) were for WTR in men and for PBF in women, although the confidence interval (CI) for PBF was wide. In stepwise analyses, WTR was the most significant predictor in men (IRR for 1 SD = 1.58, 95% CI = 1.20-2.07), and BMI was the most significant predictor in women (IRR for 1 SD = 1.65, 95% CI = 1.29-2.11). However, by ROC analyses, thigh circumference was the only variable significantly worse than WTR in men or BMI in women at predicting NIDDM. CONCLUSIONS-- Measurements such as waist circumference, WTR, weight, and BMI may be useful as more complicated measurements, such as PBF by bioelectrical resistance, for identifying groups of individuals whose body habitus places them at high risk of developing NIDDM.
SN  - 0149-5992
AD  - Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona
U2  - PMID: 7497850.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kitamura, Toshinori
AU  - Watanabe, Mayumi
AU  - Fujino, Masako
AU  - Fujihara, Shigeki
AU  - Aoki, Mitsuka
AU  - Ura, Chiaki
T1  - Factorial Structure and Correlates of Marital Adjustment in a Japanese Population: A Community Study.
JO  - Journal of Community Psychology
JF  - Journal of Community Psychology
Y1  - 1995/04//
VL  - 23
IS  - 2
M3  - Article
SP  - 117
EP  - 126
PB  - John Wiley & Sons, Inc.
SN  - 00904392
AB  - A total of 146 married inhabitants (67 men and 79 women) in a provincial city of Japan were interviewed to examine marital adjustment and its psychosocial determinants. Fifteen items of the Short Marital Adjustment Test (Locke & Wallace. 1959) (LWT), a self-rating questionnaire, were transformed into a semi-structured interview together with two new items. Factor analysis yielded five factors which were interpreted as dyadic consensus, satisfaction, flexibility, home-loving, and interest-sharing. Better marital adjustment in women was correlated with higher standard of living, lower neuroticism, and a more caring father, whereas in men it was correlated with lower psychoticism and a more caring mother. Longitudinal studies are needed to throw more tight on the determinants of marital adjustment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MARRIED people
KW  - PSYCHOMETRICS
KW  - DOMESTIC relations
KW  - MARRIAGE
KW  - PSYCHOLOGY
KW  - JAPAN
N1  - Accession Number: 11985723; Kitamura, Toshinori 1 Watanabe, Mayumi 2 Fujino, Masako 2 Fujihara, Shigeki 3 Aoki, Mitsuka 2 Ura, Chiaki 4; Affiliation:  1: Department of Sociocultural Environmental Research, National Institute of Mental Health, Ichikawa, Japan.  2: Department of School Education, Graduate School of Education, Yokohama National University, Yokohama, Japan.  3: Yamanashi Prefectural Mental Health Centre, Kofu, Japan.  4: Faculty of Psychology, Tokyo Gakugei University, Tokyo, Japan.; Source Info: Apr95, Vol. 23 Issue 2, p117; Subject Term: MARRIED people; Subject Term: PSYCHOMETRICS; Subject Term: DOMESTIC relations; Subject Term: MARRIAGE; Subject Term: PSYCHOLOGY; Subject Term: JAPAN; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107427602
T1  - Rehabilitating patients with idiopathic inflammatory myopathy.
AU  - Hicks JE
Y1  - 1995/04//1995 Apr
N1  - Accession Number: 107427602. Language: English. Entry Date: 19951101. Revision Date: 20150818. Publication Type: Journal Article; pictorial. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8608119. 
KW  - Muscular Diseases -- Rehabilitation
KW  - Therapeutic Exercise
KW  - Isometric Exercises
KW  - Assistive Technology
SP  - 41
EP  - 52
JO  - Journal of Musculoskeletal Medicine
JF  - Journal of Musculoskeletal Medicine
JA  - J MUSCULOSKELETAL MED
VL  - 12
IS  - 4
CY  - Framingham, Massachusetts
PB  - United Business Media
AB  - Patients with idiopathic inflammatory myopathy (IIM) need to begin rehabilitation early. A history and physical examination that includes a manual muscle test and functional evaluation are prerequisites to rehabilitation. Heat and massage, a tilt table, exercise, and assistive devices all help patients to cope with functional disability. The exercise program begins with stretching and passive range of motion and progresses to include isometric, isotonic, and low-intensity aerobic activities. Performing these exercises in a gravity-eliminated position may help some patients who are unable to move their muscles against gravity. Education about IIM helps patients to develop realistic expectations about outcome.
SN  - 0899-2517
AD  - Department of Rehabilitation Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107425786
T1  - Programs conducting/sponsoring female controlled barrier research.
AU  - Alexander NJ
Y1  - 1995/04//1995 Apr
N1  - Accession Number: 107425786. Language: English. Entry Date: 19951101. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Sexually Transmitted Diseases -- Prevention and Control
KW  - Contraceptive Devices
KW  - Contraceptive Agents
KW  - Clinical Research
KW  - HIV Infections
KW  - Women's Health
KW  - Female Condoms
KW  - Male
KW  - Female
SP  - 209
EP  - 214
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 4
IS  - 2
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1059-7115
AD  - Contraceptive Development Branch, Center for Population Research, National Institute of Child Health and Human Development
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106983078
T1  - Review: pain associated with HIV infection.
AU  - Hirschfeld S
AU  - Morris BK
Y1  - 1995/04//1995 Apr
N1  - Accession Number: 106983078. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article; algorithm; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9107942. 
KW  - HIV Infections -- Complications
KW  - Pain
KW  - Pain -- Etiology
KW  - Pain -- Therapy
KW  - Pain Measurement
SP  - 63
EP  - 74
JO  - Pediatric AIDS & HIV Infection
JF  - Pediatric AIDS & HIV Infection
JA  - PEDIATR AIDS HIV INFECT
VL  - 6
IS  - 2
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1045-5418
AD  - Pediatric Branch, National Cancer Institute, Bethesda, MD
U2  - PMID: 11361383.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107408812
T1  - Reliability and validity of the Modified Erikson Psychosocial Stage Inventory in diverse samples.
AU  - Leidy NK
AU  - Darling-Fisher CS
Y1  - 1995/04//
N1  - Accession Number: 107408812. Language: English. Entry Date: 19950601. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Modified Erikson Psychosocial Stage Inventory (MEPSI); Self-Transcedence in Aging Scale or STAS (Reed); Social Adjustment Rating Scale Self-Report (SAS-SR) (Erickson et al); Post-Partum Self-Evaluation Questionnaire (PSQ) (Lederman, Weingarten and Lederman). Grant Information: Studies described in this manuscript were supported by the following grants: National Research Service Award, DHHS (F31-NU05685), Rackham Dissertation Grant, University of Michigan, and Rho Chapter of Sigma Theta Tau, University of Arizona Foundation Grant, National Research Service Award, DHHS (F31-NU05758), Rackham Dissertation Grant, University of of Michigan, Rho Chapter of Sigma Theta Tau, and a Biomedical Research Support Grant, University of Arizona. NLM UID: 7905435. 
KW  - Instrument Validation
KW  - Erikson's Theory of Human Development
KW  - Funding Source
KW  - Secondary Analysis
KW  - Construct Validity
KW  - Sex Factors
KW  - Age Factors
KW  - Health Status
KW  - Analysis of Variance
KW  - Multivariate Analysis of Variance
KW  - Coefficient Alpha
KW  - Descriptive Statistics
KW  - Pearson's Correlation Coefficient
KW  - Hemophilia
KW  - Lung Diseases, Obstructive
KW  - Univariate Statistics
KW  - Research Instruments
KW  - Male
KW  - Female
KW  - Human
SP  - 168
EP  - 187
JO  - Western Journal of Nursing Research
JF  - Western Journal of Nursing Research
JA  - WEST J NURS RES
VL  - 17
IS  - 2
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
AB  - The Modified Erikson Psychosocial Stage Inventory (MEPSI) is a relatively simple survey measure designed to assess the strength of psychosocial attributes that arise from progression through Erikson's eight stages of development. The purpose of this study was to employ secondary analysis to evaluate the internal-consistency reliability and construct validity of the MEPSl across four diverse samples: healthy young adults, hemophilic men, healthy older adults. and older adults with chronic obstructive pulmonary disease. Special attention was given to the perforrnance of the measure across gender, with exploratory analyses examining possible age cohort and health status effects. Internal-consistency estimates for the aggregate measure were high, whereas subscale reliability levels varied across age groups. Construct validity was supported across samples. Gender, cohort, and health effects offered interesting psychometric and theoretical insights and direction for further research. Findings indicated that the MEPSI might be a useful instrument for operationalizing and testing Eriksonian developmental theory in adults.
SN  - 0193-9459
AD  - National Institutes of Health, Building 31, Room 5B25, 9000 Rockville Pike, Bethesda, MD 20892-2178
U2  - PMID: 7732684.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854619
T1  - Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin's lymphoma.
AU  - Travis LB
AU  - Curtis RE
AU  - Glimelius B
AU  - Holowaty EJ
AU  - Van Leeuwen FE
AU  - Lynch CF
AU  - Hagenbeek A
AU  - Stovall M
AU  - Banks PM
AU  - Adami J
Y1  - 1995/04/05/
N1  - Accession Number: 105854619. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Bladder Neoplasms -- Chemically Induced
KW  - Cyclophosphamide -- Adverse Effects
KW  - Kidney Neoplasms -- Chemically Induced
KW  - Lymphoma, Non-Hodgkin's -- Drug Therapy
KW  - Neoplasms, Second Primary -- Chemically Induced
KW  - Aged
KW  - Case Control Studies
KW  - Cyclophosphamide -- Administration and Dosage
KW  - Cyclophosphamide -- Therapeutic Use
KW  - Dose-Response Relationship, Drug
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Prospective Studies
KW  - Radiotherapy, Adjuvant
KW  - Human
SP  - 524
EP  - 530
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 7
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Md, USA.
U2  - PMID: 7707439.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107260060
T1  - Cancer screening behaviors and attitudes of women in southeastern Minnesota.
AU  - Kottke TE
AU  - Trapp MA
AU  - Fores MM
AU  - Kelly AW
AU  - Jung S
AU  - Novotny PJ
AU  - Panser LA
AU  - Kottke, T E
AU  - Trapp, M A
AU  - Fores, M M
AU  - Kelly, A W
AU  - Jung, S H
AU  - Novotny, P J
AU  - Panser, L A
Y1  - 1995/04/12/
N1  - Accession Number: 107260060. Language: English. Entry Date: 19980501. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Dietrich A J. Attitudes about cancer screening: dinnertime bias. (JAMA) 10/18/95; 274 (15): 1200-1200. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: CA 57825/CA/NCI NIH HHS/United States. NLM UID: 7501160. 
KW  - Cancer Screening
KW  - Cervical Smears
KW  - Mammography
KW  - Physical Examination
KW  - Breast
KW  - Breast Neoplasms -- Prevention and Control
KW  - Cervix Neoplasms -- Prevention and Control
KW  - Patient Attitudes
KW  - Confidence Intervals
KW  - Multiple Logistic Regression
KW  - Interviews
KW  - Telephone
KW  - Minnesota
KW  - Random Sample
KW  - Surveys
KW  - Self Report
KW  - Demography
KW  - Funding Source
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 1099
EP  - 1105
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 273
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objectives: To determine the rates at which women received screening Papanicolaou tests, clinical breast examinations, and mammography and to determine the extent to which these women might be expected to respond to screening recommendations from their physicians.Design: Random-digit-dial telephone interviews conducted in January 1993.Setting: Fifteen counties in southeastern Minnesota.Subjects: A sample of 1019 women who completed the telephone interview.Main Outcome Measures: Self-reported Papanicolaou test, clinical breast examination, and mammography screening rates, with verification from medical records for a randomly selected subsample of 200 respondents who reported having had a test within 1 year of the interview.Results: For women aged 18 years and older, 60% (95% confidence interval, +/- 3.4%) reported having had a Papanicolaou test within the preceding year. For women 40 years of age and older, 57% (95% confidence interval, +/- 3.5%) reported having had a clinical breast examination in the past year, and 46% (95% confidence interval, +/- 3.6%) reported having had a screening mammogram within 1 year. The verified 1-year Papanicolaou test and mammogram rates were 35% and 33%, respectively. More than 90% of the respondents expressed a willingness to have these tests if their physicians were to advise them that the tests were indicated. However, 53% and 54% of the respondents, respectively, said that they either did not care or did not want their physicians to remind them when they were due for a Papanicolaou test or a mammogram.Conclusions: Although self-reported screening rates in this population meet Healthy People 2000 goals, verified rates were significantly below target levels. A substantial proportion of women in this population remain ambivalent about participating in cancer detection programs.
SN  - 0098-7484
AD  - National Cancer Institute-Designated Mayo Comprehensive Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
AD  - National Cancer Institute-Designated Mayo Comprehensive Cancer Center, Harwick 6, Mayo Clinic and Foundation, Rochester, MN 55905
U2  - PMID: 7707597.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107260060&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107379803
T1  - Cancer screening behaviors and attitudes of women in southeastern Minnesota.
AU  - Kottke TE
AU  - Trapp MA
AU  - Fores MM
AU  - Kelly AW
AU  - Jung S
AU  - Novotny PJ
AU  - Panser LA
Y1  - 1995/04/12/
N1  - Accession Number: 107379803. Language: English. Entry Date: 19980501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by National Institutes of Health grant CA 57825 and Fondo de Investigaciones Sanitarias grant 93/5379 to (Dr Fores). NLM UID: 7501160. 
KW  - Attitude to Health
KW  - Cancer Screening -- Utilization
KW  - Breast Neoplasms -- Prevention and Control
KW  - Cervix Neoplasms -- Prevention and Control
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Data Analysis, Statistical
KW  - Funding Source
KW  - Minnesota
KW  - Female
KW  - Mammography -- Utilization
KW  - Cervical Smears -- Utilization
KW  - Physical Examination -- Utilization
KW  - Human
SP  - 1099
EP  - 1105
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 273
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - National Cancer Institute-Designated Mayo Comprehensive Cancer Center, Mayo Clinic and Foundation, Rochester, Minn
U2  - PMID: 7707597.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Merta, Aleš
AU  - Aksamit, Robert R.
AU  - Kasir, Judith
AU  - Cantoni, Giulio L.
T1  - The gene and pseudogenes of rat S-adnosyl-L-homocysteine hydrolase.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/04/15/
VL  - 229
IS  - 2
M3  - Article
SP  - 575
EP  - 582
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Studies gene and pseudogenes of rat S-adenosyl-L-homocysteine hydrolase.  Nucleotide sequence of both the exons and introns of the rat AdoHcy hydrolase gene; Characteristics of AdoHyc hydrolase similar to housekeeping genes.
KW  - HYDROLASES
KW  - HOMOCYSTEINE
KW  - NUCLEOTIDE sequence
KW  - EXONS (Genetics)
KW  - INTRONS
KW  - BIOCHEMISTRY
N1  - Accession Number: 12143632; Merta, Aleš 1 Aksamit, Robert R. 1 Kasir, Judith 1 Cantoni, Giulio L. 1; Affiliation:  1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, USA; Source Info: 4/15/95, Vol. 229 Issue 2, p575; Subject Term: HYDROLASES; Subject Term: HOMOCYSTEINE; Subject Term: NUCLEOTIDE sequence; Subject Term: EXONS (Genetics); Subject Term: INTRONS; Subject Term: BIOCHEMISTRY; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dramsi, Shaynoor
AU  - Braun, Laurence
AU  - Cossart, Pascale
AU  - Biswas, Indranil
AU  - Maguin, Emmanuelle
AU  - Mastroeni, Pietro
T1  - Entry of Listeria monocytogenes into hepatocytes requires expression of InIB, a surface protein of the internalin multigene family.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995/04/15/
VL  - 16
IS  - 2
M3  - Article
SP  - 251
EP  - 261
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The intracellular bacterium <em>Listeria monocytogenes</em> can invade several types of normally non-phagocytic cells. Entry into cultured epithelial cells requires the expression of <em>inlA</em>, the first gene of an operon, comprising two genes: <em>inlA</em>, which encodes internalin, an 800-amino-acid protein, and <em>inlB</em>, which encodes a 630-amino-acid protein. Several genes homologous to <em>inlA</em> are detected in the genome of <em>L. monocytogenes; InlB</em> is one of them. We have assessed the role of <em>inlB</em> in invasiveness of <em>L. monocytogenes</em> by constructing isogenic chromosomal deletion mutants in the <em>inlAB</em> locus. Our findings indicate that: i) <em>inlB</em> is required for entry of <em>L. monocytogenes</em> into hepatocytes, but not into intestinal epithelial ceils; ii) <em>inlB</em> encodes a surface protein; iii) internalin plays a role for entry into some hepatocyte cell lines. These results provide the first insight into the cell tropism displayed by <em>L. monocytogenes</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Listeria monocytogenes
KW  - Liver cells
KW  - Cells
KW  - Gene expression
KW  - Proteins
N1  - Accession Number: 16065231; Dramsi, Shaynoor 1; Braun, Laurence 1; Cossart, Pascale 1; Biswas, Indranil 2,3; Maguin, Emmanuelle 2; Mastroeni, Pietro 4; Affiliations: 1: Unite des Intéractions Bactéries-Cellules et CNRS URA 1300, Institut Pasteur, 28 rue du Dr Roux, Paris 75015, France; 2: Laboratoire de Genetique Microbienne, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy en Josas, France; 3: National institute of Diabetes and Digestive and Kidney Diseases, NIH, Building 10 R.9D15, Bethesda, Maryland 20892, USA; 4: Department of Pathology, University of Cambridge, Tennis Court Read, Cambridge, CB2 1QP, UK; Issue Info: Apr1995, Vol. 16 Issue 2, p251; Subject Term: Listeria monocytogenes; Subject Term: Liver cells; Subject Term: Cells; Subject Term: Gene expression; Subject Term: Proteins; Number of Pages: 11p; Illustrations: 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105852712
T1  - Trends in pharmacologic management of hypertension in the United States.
AU  - Manolio TA
AU  - Cutler JA
AU  - Furberg CD
AU  - Psaty BM
AU  - Whelton PK
AU  - Applegate WB
Y1  - 1995/04/24/
N1  - Accession Number: 105852712. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440. 
KW  - Antihypertensive Agents -- Therapeutic Use
KW  - Hypertension -- Drug Therapy
KW  - Adult
KW  - Aged
KW  - Antihypertensive Agents -- Adverse Effects
KW  - Antihypertensive Agents -- Economics
KW  - Cardiovascular Diseases -- Etiology
KW  - Cardiovascular Diseases -- Mortality
KW  - Cardiovascular Diseases -- Prevention and Control
KW  - Confounding Variable
KW  - Drug Therapy -- Economics
KW  - Drug Therapy -- Trends
KW  - Female
KW  - Hypertension -- Complications
KW  - Male
KW  - Middle Age
KW  - Treatment Outcomes
KW  - United States
KW  - Human
SP  - 829
EP  - 837
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
JA  - ARCH INTERN MED
VL  - 155
IS  - 8
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0003-9926
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md, USA.
U2  - PMID: 7717791.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Figueroa, Janis Barry
AU  - Breen, Nancy
T1  - Significance of underclass residence on the stage of breast or cervical cancer diagnosis.
JO  - American Economic Review
JF  - American Economic Review
Y1  - 1995/05//
VL  - 85
IS  - 2
M3  - Article
SP  - 112
PB  - American Economic Association
SN  - 00028282
AB  - Socioeconomic status plays a significant role in determining the timing of and access to cervical and breast cancer screening, diagnosis and survival rates. In the United States, breast cancer is the most common cancer among women with a higher incidence among white than Afro-American women. While the incidence of cervical cancer among Afro-Americn women is much higher than white women. An estimated  81 percent of cervical cancers and 13 percent of breast cancers are now detected in situ, or as precancerous lesions. Early detection of these cancers requires medical intervention in the form of screening and clinical examination, as monitoring and follow-through on ambiguous findings. Findings are that women in Atlanta were less likely and women in Detroit more likely to he diagnosed later than women in San Francisco. Living without a spouse also increased the probability of late-stage diagnosis, as did age. As predicted, residence in an underclass area significantly increased the likelihood of late-stage diagnosis. It has been concluded that knowledge, transportation, attitudes, differential physician advice, and time demands all help explain why poorer women are less likely to receive screening tests.
KW  - BREAST cancer
KW  - BREAST cancer -- Diagnosis
KW  - CERVICAL cancer
KW  - CERVICAL cancer -- Diagnosis
KW  - BLACK women
KW  - MEDICAL screening
KW  - CANCER in women
KW  - UNITED States
N1  - Accession Number: 9507060107; Figueroa, Janis Barry 1; Breen, Nancy 2; Affiliations: 1: Department of Social Sciences Fordham University, 113 West 60th Street, New York, NY 10023.; 2: Applied Research Branch, Division of Cancer Prevention and Control National Cancer Institute, Executive Plaza North, Room 313, Bethesda, MD 20892.; Issue Info: May95, Vol. 85 Issue 2, p112; Subject Term: BREAST cancer; Subject Term: BREAST cancer -- Diagnosis; Subject Term: CERVICAL cancer; Subject Term: CERVICAL cancer -- Diagnosis; Subject Term: BLACK women; Subject Term: MEDICAL screening; Subject Term: CANCER in women; Subject: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107189854
T1  - Fruit and vegetable intake in the United States: the baseline survey of the Five A Day for Better Health Program.
AU  - Subar AF
AU  - Heimendinger J
AU  - Patterson BH
AU  - Krebs-Smith SM
AU  - Pivonka E
AU  - Kessler R
AU  - Subar, A F
AU  - Heimendinger, J
AU  - Patterson, B H
AU  - Krebs-Smith, S M
AU  - Pivonka, E
AU  - Kessler, R
Y1  - 1995/05//1995 May-Jun
N1  - Accession Number: 107189854. Language: English. Entry Date: 19990501. Revision Date: 20161127. Publication Type: journal article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. Instrumentation: Block Food Frequency Questionnaire. NLM UID: 8701680. 
KW  - Fruit
KW  - Vegetables
KW  - Diet -- United States
KW  - Random Sample
KW  - United States
KW  - Research Instruments
KW  - P-Value
KW  - T-Tests
KW  - Chi Square Test
KW  - Adult
KW  - Adolescence
KW  - Middle Age
KW  - Aged
KW  - Linear Regression
KW  - Female
KW  - Male
KW  - Survey Research
KW  - Telephone
KW  - Race Factors
KW  - Sex Factors
KW  - Human
SP  - 352
EP  - 360
JO  - American Journal of Health Promotion
JF  - American Journal of Health Promotion
JA  - AM J HEALTH PROMOT
VL  - 9
IS  - 5
PB  - Sage Publications Inc.
AB  - Purpose: The purpose of the Five A Day Baseline Survey was to assess fruit and vegetable intake and associated factors among US adults.Design: Questionnaires querying frequency of intake of 33 fruits and vegetables, as well as demographics, attitudes, and knowledge related to fruits and vegetables were administered by telephone.Setting: The study was a nationally representative random digit dial survey conducted by telephone in the summer of 1991; response rate was 42.8%.Subjects: Respondents were 2811 US adults (including an oversample of African-Americans and Hispanics).Measures: Mean and median self-reported intakes of fruits and vegetables were calculated. Estimated servings per week were adjusted on the basis of responses to summary questions regarding overall fruit and vegetable intakes.Results: Median intake of fruits and vegetables was 3.4 servings per day. Linear regressions (accounting for no more than 10% of the variation) showed that education, income, and smoking status were predictors of fruit and vegetable intake and that intake increased with education, income, and nonsmoking status. Women had higher intakes than men at all ages; these differences between men and women increased with age. Fruit and vegetable intakes increased with age for whites and Hispanics, but not for African-Americans.Conclusions: Fruit and vegetable intake among adults in the United States is lower than the recommended minimum of five daily servings. These data will be useful in targeting campaign efforts and in assessing progress of the Five A Day for Better Health Program.
SN  - 0890-1171
AD  - National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, Maryland 20892-7344, USA
AD  - National Cancer Institute, Division of Cancer Prevention and Control, 6130 Executive Blvd., MSC 7344, Bethesda, MD 20892-7344
U2  - PMID: 10150767.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Ashery, Rebecca Sager
AU  - Carlson, Robert G.
AU  - Falck, Russel S.
AU  - Siegal, Harvey A.
AU  - Jichuan Wang
T1  - Female Condom Use among Injection Drug- and Crack Cocaine-Using Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/05//
VL  - 85
IS  - 5
M3  - Letter
SP  - 736
EP  - 737
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented about a study on the use of condoms by injection drug- and crack-using women in Dayton and Columbus, Ohio.
KW  - LETTERS to the editor
KW  - FEMALE condoms
N1  - Accession Number: 20700517; Ashery, Rebecca Sager 1 Carlson, Robert G. 2 Falck, Russel S. 2 Siegal, Harvey A. 2 Jichuan Wang 2; Affiliation:  1: Community Research Branch, National Institute on Drug Abuse, Rockville, Md.  2: Department of Community Health, Wright State University School of Medicine, Dayton, Ohio; Source Info: May95, Vol. 85 Issue 5, p736; Subject Term: LETTERS to the editor; Subject Term: FEMALE condoms; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107413844
T1  - Patient resources. Tapping the SEER database... The Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute is one of the most frequently tapped sources of data to support the incidence, mortality, survival, and trend components of these reports.
AU  - Harras A
Y1  - 1995/05//1995 May-Jun
N1  - Accession Number: 107413844. Language: English. Entry Date: 19950801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. NLM UID: 9312355. 
KW  - Neoplasms -- Epidemiology -- United States
KW  - Resource Databases
KW  - United States
KW  - Information Resources
KW  - Resource Databases -- Utilization
SP  - 184
EP  - 186
JO  - Cancer Practice
JF  - Cancer Practice
JA  - CANCER PRACT
VL  - 3
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 1065-4704
AD  - SEER Program, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland
U2  - PMID: 7599676.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107205919
T1  - What you should know about clinical trials.
AU  - Trimble EL
AU  - Park RC
Y1  - 1995/05//1995 May
N1  - Accession Number: 107205919. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0367022. 
KW  - Clinical Trials
SP  - 123
EP  - 130
JO  - Contemporary OB/GYN
JF  - Contemporary OB/GYN
JA  - CONTEMP OB GYN
VL  - 40
IS  - 5
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Clinical trials represent the optimal way of defining effective medical intervention. Through them, we can determine the best way to help women who come to us for care.
SN  - 0090-3159
AD  - Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107388888
T1  - Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study.
AU  - Chew EY
AU  - Mills JL
AU  - Metzger BE
AU  - Remaley NA
AU  - Jovanovic-Peterson L
AU  - Knopp RH
AU  - Conley M
AU  - Rand L
AU  - Simpson JL
AU  - Holmes LB
AU  - Aarons JH
AU  - Chew, E Y
AU  - Mills, J L
AU  - Metzger, B E
AU  - Remaley, N A
AU  - Jovanovic-Peterson, L
AU  - Knopp, R H
AU  - Conley, M
AU  - Rand, L
AU  - Simpson, J L
Y1  - 1995/05//
N1  - Accession Number: 107388888. Corporate Author: National Institute of Child Health and Human Development. Diabetes in Early Pregnant Study. Language: English. Entry Date: 19961101. Revision Date: 20161113. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: RR-00037-28/RR/NCRR NIH HHS/United States. NLM UID: 7805975. 
KW  - Diabetes Mellitus, Type 1 -- Physiopathology
KW  - Diabetic Retinopathy -- Physiopathology
KW  - Pregnancy in Diabetes -- Physiopathology
KW  - Chi Square Test
KW  - Logistic Regression
KW  - Blood Glucose Monitoring
KW  - Blood Pressure
KW  - Prospective Studies
KW  - Confidence Intervals
KW  - Disease Progression
KW  - Female
KW  - Perinatal Death -- Epidemiology
KW  - Hemoglobin A, Glycosylated -- Analysis
KW  - Pregnancy
KW  - Risk Factors
KW  - Pregnancy Trimester, First
KW  - Puerperal Disorders -- Physiopathology
KW  - Funding Source
KW  - Human
SP  - 631
EP  - 637
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 18
IS  - 5
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - Objective: To evaluate the role of metabolic control in the progression of diabetic retinopathy during pregnancy.Research Design and Methods: We conducted a prospective cohort study of 155 diabetic women in the Diabetes in Early Pregnancy Study followed from the periconceptional period to 1 month postpartum. Fundus photographs were obtained shortly after conception (95% within 5 weeks of conception) and within 1 month postpartum. Glycosylated hemoglobin was measured weekly during the 1st trimester and monthly thereafter.Results: In the 140 patients who did not have proliferative retinopathy at baseline, progression of retinopathy was seen in 10.3, 21.1, 18.8, and 54.8% of patients with no retinopathy, microaneurysms only, mild nonproliferative retinopathy, and moderate-to-severe nonproliferative retinopathy at baseline, respectively. Proliferative retinopathy developed in 6.3% with mild and 29% with moderate-to-severe baseline retinopathy. Elevated glycosylated hemoglobin at baseline and the magnitude of improvement of glucose control through week 14 were associated with a higher risk of progression of retinopathy (adjusted odds ratio for progression in those with glycohemoglobin > or = 6 SD above the control mean versus those within 2 SD was 2.7; 95% confidence interval was 1.1-7.2; P = 0.039).Conclusions: The risk for progression of diabetic retinopathy was increased by initial glycosylated hemoglobin elevations as low as 6 SD above the control mean. This increased risk may be due to suboptimal control itself or to the rapid improvement in metabolic control that occurred in early pregnancy. Excellent metabolic control before conception may be required to avoid this increase in risk. Those with moderate-to-severe retinopathy at conception need more careful ophthalmic monitoring, particularly if their diabetes was suboptimally controlled at conception.
SN  - 0149-5992
AD  - Division of Biometry and Epidemiology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2510, USA
U2  - PMID: 8586000.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Shrager, Richard I.
AU  - Hendler, Richard W.
AU  - Bose, Salil
T1  - The ability of actinic light to modify the bacteriorhodopsin photocycle.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/05//5/1/95
VL  - 229
IS  - 3
M3  - Article
SP  - 589
EP  - 595
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Examines a variety of contending bacteriorhodopsin (BR) photocycle models.  Proposals of four separate categories that include models of fixed shape, models based on cooperativity, models based on heterogeneity and models based on a mixture of cooperativity and heterogeneity; Factors involved in the adaptation of BR photocycle to different levels of actinic light.
KW  - BACTERIORHODOPSIN
KW  - BACTERIAL pigments
KW  - BACTERIAL proteins
KW  - HALOBACTERIUM
KW  - ENERGY metabolism
KW  - BACTERIA
N1  - Accession Number: 12144563; Shrager, Richard I. 1 Hendler, Richard W. 2 Bose, Salil 2; Affiliation:  1: Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, USA  2: Laboratory of Cell Biology, National Heart, Lung, and BLood Institute, National Institutes of Health, USA; Source Info: 5/1/95, Vol. 229 Issue 3, p589; Subject Term: BACTERIORHODOPSIN; Subject Term: BACTERIAL pigments; Subject Term: BACTERIAL proteins; Subject Term: HALOBACTERIUM; Subject Term: ENERGY metabolism; Subject Term: BACTERIA; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107411313
T1  - How to develop a poster.
AU  - Thompkins DL
Y1  - 1995/05//1995 May-Jun
N1  - Accession Number: 107411313. Language: English. Entry Date: 19950701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8804311. 
KW  - Posters -- Methods
KW  - Nursing Organizations
KW  - Meetings
SP  - 111
EP  - 113
JO  - Journal of Intravenous Nursing
JF  - Journal of Intravenous Nursing
JA  - J INTRAVENOUS NURS
VL  - 18
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - This article first appeared in the September/October 1989 issue of Journal of Intravenous Nursing. It has been reprinted because it provides information that can be used on a continual basis.
SN  - 0896-5846
AD  - National Institutes of Health in Bethesda, Maryland
U2  - PMID: 7539835.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107411313&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Roh, Joo-Young
AU  - Stanley, John R.
T1  - Plakoglobin Binding by Human Dsg3 (Pemphigus Vulgaris Antigen) in Keratinocytes Requires the Cadherin-Like Intracytoplasmic Segment.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/05//
VL  - 104
IS  - 5
M3  - Article
SP  - 720
EP  - 724
SN  - 0022202X
AB  - Desmogleins are transmembrane destnosonial cadherins. Two desmogleins, Dsg3 and Dsg1, have been shown to bind plakoglobin, an intracytoplasmic (IC) desmosomal plaque protein. This binding may be critical for desmosome assembly or stability. The IC domain of desmogleins consists of subdomains that are either desmoglein specific or homologous with the IC region of classical cadherins, Here we identify the domains of human Dsg3 that are critical for plakoglobin binding in human keratinocytes. We constructed eukaryotic expression vectors containing chimeric cDNAs that encode the extracellular domain of mouse E-cadherin (Ecad) with the transmembrane and IC domains of Dsg3, with increasing truncations eliminating various IC subdomains from the carboxy-terminus. These constructs were used for transient transfection of HaCaT cells. Extracts were subjected to immunoprecipition with an anti-mouse Ecad antibody (that does not precipitate human Ecad), thus precipitating the chimeric protein and any tightly associated plakoglobin. Co-precipitation of plakoglobin was confirmed by immunoblotting. These data show that the desinoglein-specific IC subdomains are not necessary for plakoglobin binding, but the carboxy-terminal 87 amino acids of the IC-cadherin-like segment subdomain are critical. Finally, we confirmed these results outside cells with <em>in vitro</em> transcription and translation, which also demonstrates that the Dsg3-plakoglobin interaction is direct and does not depend on other cellular factors. These results underscore the importance of a region, highly conserved in all desmogleins, in the carboxy terminus of the IC-cadherin-like subdomain for the localization of plakoglobin to desmosomes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - PROTEINS
KW  - EUKARYOTIC cells
KW  - GLOBIN
KW  - DESMOSOMES
KW  - AMINO acids
N1  - Accession Number: 12606963; Roh, Joo-Young Stanley, John R. 1; Affiliation:  1: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May95, Vol. 104 Issue 5, p720; Subject Term: KERATINOCYTES; Subject Term: PROTEINS; Subject Term: EUKARYOTIC cells; Subject Term: GLOBIN; Subject Term: DESMOSOMES; Subject Term: AMINO acids; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12606963
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12606963&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hertl, Michael
AU  - Neckers, Leonard M.
AU  - Katz, Stephen I.
T1  - Inhibition of Interferon-γ-Induced Intercellular Adhesion Molecule-1 Expression on Human Keratinocytes by Phosphorothioate Antisense Oligodeomynucleotides Is the Consequence of Antisense-Specific and Antisense-Non-Specific Effects.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/05//
VL  - 104
IS  - 5
M3  - Article
SP  - 813
EP  - 818
SN  - 0022202X
AB  - Expression of intercellular adhesion molecule-1 (ICAM-1) by keratinocytes is an important event in the pathogenesis of T-cell-mediated inflammatory skin diseases. To determine if ICAM-1 expression could be selectively modulated, two antisense phosphorothioate oligonucleotides (S-ODN) targeting the translation initiation and 3' untranslated regions of ICAM-1 mRNA were added as lipid complexes to cultures of keratinocytes. Interferon-γ was added after 24 h to induce ICAM-1 expression, which was quantitated by flow cytometry after 48 h. The S-ODN targeting the translation initiation site did not inhibit ICAM-1 expression at 0.2-20.0 μM. In contrast, 0.2- 1.0 μM of the S-ODN targeting a site in the 3' untranslated region abrogated ICAM-1 expression in up to 75% of the keratinocytes; this inhibition was reversible when complementary sense S-ODN was added. Phosphodiester ODN (PD-ODN) targeting the same sites did not inhibit ICAM-1 expression on keratinocytes, most likely as a consequence of rapid degradation. Inhibition of ICAM-1 by the antisense S-ODN was selective; expression of β2-microglobulin, α3-integrin, and β1-integrin remained largely unaffected and interferon γ-induced HLA-DR expression was inhibited to a much lesser extent than ICAM-1. Antisense-non-specific inhibition was also noted in that two scrambled S-ODN with an identical nucleotide (14 of 20 cytosines) composition inhibited ICAM-1 expression in up to 44% of the keratinocytes, whereas a degenerate S-ODN did not. The data demonstrate the complex effects exerted by antisense S-ODN in that ICAM-1 expression was inhibited via antisense-non-specific mechanisms probably due to the intrinsic properties of the S-ODN as well as via the anticipated sequence-specific mechanisms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERFERONS
KW  - CELL adhesion
KW  - KERATINOCYTES
KW  - NUCLEOTIDES
KW  - SKIN diseases
KW  - MESSENGER RNA
N1  - Accession Number: 12607006; Hertl, Michael 1 Neckers, Leonard M. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Clinical Pharmacology Branches, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May95, Vol. 104 Issue 5, p813; Subject Term: INTERFERONS; Subject Term: CELL adhesion; Subject Term: KERATINOCYTES; Subject Term: NUCLEOTIDES; Subject Term: SKIN diseases; Subject Term: MESSENGER RNA; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12607006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12607006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Atkinson, Jane C.
AU  - Royce, Leah S.
AU  - Robert Weliner, Leah S.
AU  - Pillemer, Stanley R.
AU  - Bermudez, Deborah
AU  - Fox, Philip C.
T1  - Anti-salivary antibodies in primary Sjögren's syndrome.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1995/05//
VL  - 24
IS  - 5
M3  - Article
SP  - 206
EP  - 212
SN  - 09042512
AB  - Earlier studies have described an antibody that recognized salivary ductal epithelium in sera from 15-50% of patients with primary Sjoögren's syndrome; however, the specific salivary antigen in those studies was not identified. The present study further investigated this unknown salivary antigen. Twenty-nine of 31 patients (94%) with primary Sjoögren's syndrome demonstrated IgG antinuclear antibodies that bound to an epithehial cell line with ductal characteristics derived from a human salivary gland. Seventy-seven percent of these patients had serum antibodies that bound to ductal cells of normal human parotid tissue after formalin fixation. Western blots of cell extracts, immunofluorescence, and adsorption studies indicated that SS-A/Ro and SS-B/La were the antigens recognized in the salivary cell line. The pattern of fluorescence seen when anti-SS-B/La bound to normal parotid tissue was identical to the fluorescence pattern of the anti-salivary ductal antibodies described in earlier literature. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SJOGREN'S syndrome
KW  - IMMUNOGLOBULINS
KW  - SALIVARY glands
KW  - EPITHELIUM
KW  - ANTIGENS
KW  - SERUM
KW  - PAROTID glands
KW  - TISSUES
KW  - autoantibodies
KW  - salivary glands
KW  - Sjoögren's syndrome
KW  - SS-A/Ro
KW  - SS-B/La.
N1  - Accession Number: 11663762; Atkinson, Jane C. 1 Royce, Leah S. 1 Robert Weliner, Leah S. 2 Pillemer, Stanley R. 3 Bermudez, Deborah 1 Fox, Philip C. 1; Affiliation:  1: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, Bethesda  2: Pathophysiology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick  3: Office of Prevention, Epidemiology, and Clinical Applications, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA; Source Info: May1995, Vol. 24 Issue 5, p206; Subject Term: SJOGREN'S syndrome; Subject Term: IMMUNOGLOBULINS; Subject Term: SALIVARY glands; Subject Term: EPITHELIUM; Subject Term: ANTIGENS; Subject Term: SERUM; Subject Term: PAROTID glands; Subject Term: TISSUES; Author-Supplied Keyword: autoantibodies; Author-Supplied Keyword: salivary glands; Author-Supplied Keyword: Sjoögren's syndrome; Author-Supplied Keyword: SS-A/Ro; Author-Supplied Keyword: SS-B/La.; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107394123
T1  - Report from the NIA. Another modifiable risk factor for cardiovascular disease? Some evidence points to arterial stiffness.
AU  - Hodes RJ
AU  - Lakatta EG
AU  - McNeil CT
Y1  - 1995/05//5/ 1/1995
N1  - Accession Number: 107394123. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Arteries -- Physiopathology
KW  - Cardiovascular Diseases -- Etiology
KW  - Cardiovascular Risk Factors
KW  - Aging
KW  - Cardiovascular Diseases -- Physiopathology
SP  - 581
EP  - 582
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - National Institute on Aging, Office of the Director, Bldg. 31, Rm. 5C35, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 7730544.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107394123&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107427310
T1  - Effect of choline supplementation on fatigue in trained cyclists.
AU  - Spector SA
AU  - Jackman MR
AU  - Sabounjian LA
AU  - Sakkas C
AU  - Landers DM
AU  - Willis WT
Y1  - 1995/05//1995 May
N1  - Accession Number: 107427310. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: This research was supported by a grant from Interneuron Pharmaceuticals Incorporated (203-11). NLM UID: 8005433. 
KW  - Amines
KW  - Fatigue
KW  - Funding Source
KW  - Cycling
KW  - Ergometry
KW  - Oxygen Consumption
KW  - Evaluation Research
KW  - Multivariate Analysis of Variance
KW  - T-Tests
KW  - Dietary Supplementation
KW  - Adult
KW  - Male
KW  - Human
SP  - 668
EP  - 673
JO  - Medicine & Science in Sports & Exercise
JF  - Medicine & Science in Sports & Exercise
JA  - MED SCI SPORTS EXERC
VL  - 27
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0195-9131
AD  - National Institutes of Health, NINDS, Neuromuscular Diseases Section, Building 10, Room 4N248, Bethesda, MD 20892
U2  - PMID: 7674870.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107427310&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107413505
T1  - Chemotherapy extravasation: a consequence of fibrin sheath formation around venous access devices.
AU  - Mayo DJ
AU  - Pearson DC
Y1  - 1995/05//1995 May
N1  - Accession Number: 107413505. Language: English. Entry Date: 19950801. Revision Date: 20150819. Publication Type: Journal Article; case study; pictorial; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Oncologic Nursing
KW  - Extravasation of Diagnostic and Therapeutic Materials
KW  - Vascular Access Devices -- Adverse Effects
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Problem Solving
KW  - Radiography
KW  - Contrast Media
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
SP  - 675
EP  - 680
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 22
IS  - 4
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - Purpose/Objectives: To describe, using two case studies, chemotherapy drug extravasation as a consequence of fibrin sheath formation. Data Sources: Journal articles, textbooks, medical records, and personal experiences. Data Synthesis: Fibrin sheath formation around venous access devices (VADs) frequently leads to persistent withdrawal occlusion (PWO). While PWO often is easily managed with small doses of thrombolytic therapy (e.g., urokinase), it may result in a more serious complication, such as chemotherapy extravasation. Conclusions: Chemotherapy should not be administered through a VAD unless a free-flowing blood return can be demonstrated. Implications for Nursing Practice: Careful nursing assessment of all VADs is important to identify complications such as fibrin sheath formation. To rule out fibrin sheath formation, nurses must obtain catheter dye studies when fibrinolytic therapy fails to restore catheter function.
SN  - 0190-535X
AD  - Critical Care/Heart, Lung and Blood and Cancer Nursing Service of the Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda MD
U2  - PMID: 7675669.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107413505&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107411521
T1  - Introduction... women's health issues.
AU  - Jenkins J
AU  - Galassi A
Y1  - 1995/05//1995 May
N1  - Accession Number: 107411521. Language: English. Entry Date: 19950701. Revision Date: 20150819. Publication Type: Journal Article; editorial. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Women's Health
KW  - Female
SP  - 77
EP  - 77
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 11
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0749-2081
AD  - National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107411523
T1  - Cancer patterns among women in the United States.
AU  - Devesa SS
Y1  - 1995/05//1995 May
N1  - Accession Number: 107411523. Language: English. Entry Date: 19950701. Revision Date: 20150819. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Women's Health
KW  - Neoplasms -- Epidemiology -- United States
KW  - United States
KW  - Age Factors
KW  - Risk Factors
KW  - Mortality
KW  - Breast Neoplasms
KW  - Lung Neoplasms
KW  - Cervix Neoplasms
KW  - Uterine Neoplasms
KW  - Ovarian Neoplasms
KW  - Race Factors
KW  - Survival
KW  - Neoplasms -- Classification
KW  - Adult
KW  - Middle Age
KW  - Female
SP  - 78
EP  - 87
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 11
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The American Cancer Society estimated that 576,000 invasive cancers would be diagnosed among American women in 1994 and that 255,000 women will have died of cancer during that year. Six cancers account for almost 70% of the cases in women and more than 60% of the deaths. Risk factors associated with breast, lung, colorectal, cervix uteri, corpus uteri, and ovarian cancers are presented. The patterns of occurrence in the population, time trends, survival rates, and etiologic factors vary considerably, suggesting a constellation of diseases in women. One of the most important factors influencing outcome is early diagnosis. (Copyright 1995 W.B. Saunders Company)
SN  - 0749-2081
AD  - Division of Cancer Etiology, National Cancer Institute, Bethesda, MD
U2  - PMID: 7604194.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107411523&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107411537
T1  - Women's health advocacy: its growth and development in oncology.
AU  - McCabe MS
AU  - Varricchio CG
AU  - Padberg R
AU  - Simpson N
Y1  - 1995/05//1995 May
N1  - Accession Number: 107411537. Language: English. Entry Date: 19950701. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Women's Health
KW  - Patient Advocacy
KW  - Oncologic Care
KW  - Neoplasms -- Organizations
KW  - Female
SP  - 137
EP  - 142
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 11
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Women's health has become a topic of national importance. Advocacy initiatives by consumers, scientists, government officials, health care professionals, industry, and the media have played a role in helping to set this agenda. Much of the current interest in women's health is the result of the women's movement and its interaction with science, medicine, and health care. Emerging consumerism and increasing public knowledge of medical and scientific topics has led to the emergence of patients as individuals seeking to actively make decisions regarding health care options. Nurses should embrace the advocacy movement and, whenever possible, work with patients and their advocates toward their many shared goals. (Copyright 1995 W.B. Saunders Company)
SN  - 0749-2081
AD  - Division of Cancer Treatment and the Division of Prevention and Control, National Cancer Institute, Bethesda MD
U2  - PMID: 7604192.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107411537&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2009-22883-001
AN  - 2009-22883-001
AU  - Zahn-Waxler, Carolyn
T1  - Introduction to special section: Parental depression and distress: Implications for development in infancy, childhood, and adolescence.
T3  - Parental Depression and Distress: Implications for Development in Infancy, Childhood, and Adolescence
JF  - Developmental Psychology
JO  - Developmental Psychology
JA  - Dev Psychol
Y1  - 1995/05//
VL  - 31
IS  - 3
SP  - 347
EP  - 348
CY  - US
PB  - American Psychological Association
SN  - 0012-1649
SN  - 1939-0599
AD  - Zahn-Waxler, Carolyn, National Institute of Mental Health, Laboratory of Developmental Psychology, Building 15-K, Bethesda, MD, US, 20892-2668
N1  - Accession Number: 2009-22883-001. Partial author list: First Author & Affiliation: Zahn-Waxler, Carolyn; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20091221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Development; Mental Disorders; Parent Child Relations; Parental Characteristics; Parents. Minor Descriptor: Adolescent Development; Childhood Development; Distress; Infant Development; Major Depression. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Page Count: 2. Issue Publication Date: May, 1995. Copyright Statement: In the public domain.
AB  - Five years ago, a special section on 'Developmental Psychopathology in Children of Depressed Mothers' was published in this journal (see Vol. 26, pp. 3-67). The present special section deals also with this topic and includes seven empirical articles. It is the product of several successful journal submissions that occurred in relatively close succession. The articles were not specifically targeted beforehand to be broadly representative of research in this domain. Work from some other excellent research programs is not included. Thus, although the content of this special section cannot be viewed as a comprehensive cross-section of current research directions, it does provide an occasion for readers to begin to assess continuities and changes in this research domain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - parental depression & distress
KW  - parental influences
KW  - child development
KW  - infant development
KW  - adolescent development
KW  - developmental psychopathology
KW  - 1995
KW  - Human Development
KW  - Mental Disorders
KW  - Parent Child Relations
KW  - Parental Characteristics
KW  - Parents
KW  - Adolescent Development
KW  - Childhood Development
KW  - Distress
KW  - Infant Development
KW  - Major Depression
KW  - 1995
DO  - 10.1037/h0092676
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-22883-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Cieplak Jr., Witold
AU  - Messer, Ronald J.
AU  - Konkel, Michael E.
AU  - Grant, Christopher C. R.
T1  - Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat--labile enterotoxin.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995/05/15/
VL  - 16
IS  - 4
M3  - Article
SP  - 769
EP  - 800
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Recent experimental evidence indicates that <em>Escherichia coli</em> heat-labile enterotoxin and the closely related cholera toxin gain access to intracellular target substrates through a brefeldin A-sensitive pathway that may involve retrograde transport through the Golgi-endoplasmic reticulum network. The A subunits of both toxins possess a carboxy-terminal tetrapeptide sequence (KDEL in cholera toxin and RDEL in the heat-labile enterotoxins) that is known to mediate the retention of eukaryotic proteins in the endoplasmic reticulum. To investigate the potential role of the RDEL sequence in the toxic activity of the heat-labile enterotoxin we constructed mutant analogues of the toxin containing single substitutions (RDGL and RDEV) or a reversed sequence (LEDR). The single substitutions had little effect on Chinese hamster ovary cell elongation or the ability to stimulate cAMP accumulation in Caco-2 cells. Reversal of the sequence reduced the ability of the toxin to increase cAMP levels in Caco-2 cells by approximately 60% and decreased the ability to elicit elongation of Chinese hamster ovary cells. The effects of the heat-labile enterotoxin were not diminished in a mutant Chinese hamster ovary cell line (V.24.1) that belongs to the End4 complementation group and possesses a temperature-sensitive block in secretion that correlates directly with the disappearance of the Golgi stacks. Collectively, these findings suggest that the brefeldin A-sensitive process involved In intoxication by the heat-labile enterotoxin does not involve RDEL-dependent retrograde transport of the A subunit through the Golgi-endoplasmic reticulum complex. The results are more consistent with a model of internalization involving translocation of the A subunit from an endosomal or a <em>trans-Golgi</em> network compartment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Bacterial toxins
KW  - Enterotoxins
KW  - Reticulum cell sarcoma
KW  - Microbiological research
N1  - Accession Number: 16169597; Cieplak Jr., Witold 1; Email Address: WC@RML.NIAID.NIH.GOV; Messer, Ronald J. 1; Konkel, Michael E. 1; Grant, Christopher C. R. 1; Affiliations: 1: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; Issue Info: May1995, Vol. 16 Issue 4, p769; Thesaurus Term: Escherichia coli; Thesaurus Term: Bacterial toxins; Subject Term: Enterotoxins; Subject Term: Reticulum cell sarcoma; Subject Term: Microbiological research; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Illustrations: 1 Diagram, 5 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105852743
T1  - Mycobacterium tuberculosis infection in pregnant and nonpregnant women infected with HIV in the Women and Infants Transmission Study.
AU  - Mofenson LM
AU  - Rodriguez EM
AU  - Hershow R
AU  - Fox HE
AU  - Landesman S
AU  - Tuomala R
AU  - Diaz C
AU  - Daniels E
AU  - Brambilla D
Y1  - 1995/05/22/
N1  - Accession Number: 105852743. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440. 
KW  - HIV Infections -- Complications
KW  - Pregnancy Complications, Infectious -- Epidemiology
KW  - Tuberculosis -- Complications
KW  - Tuberculosis -- Epidemiology
KW  - Adult
KW  - Female
KW  - Pregnancy
KW  - Prevalence
KW  - Prospective Studies
KW  - Risk Factors
KW  - Tuberculin Test
KW  - Human
SP  - 1066
EP  - 1072
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
JA  - ARCH INTERN MED
VL  - 155
IS  - 10
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0003-9926
AD  - National Institutes of Health, Rockville, Md, USA.
U2  - PMID: 7748050.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107379851
T1  - Including narcotic addiction treatment in an office-based practice.
AU  - Cooper JR
AU  - Cooper, J R
Y1  - 1995/05/24/
N1  - Accession Number: 107379851. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: journal article; commentary. Supplement Title: 5/24/95-5/31/95. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Substance Dependence -- Drug Therapy
KW  - Drug and Narcotic Control -- United States
KW  - Narcotics
KW  - Legislation, Medical -- United States
KW  - Private Practice -- Legislation and Jurisprudence -- United States
KW  - United States
SP  - 1619
EP  - 1620
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 273
IS  - 20
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Division of Clinical and Services Research, National Institute on Drug Abuse, Rockville, Md. 20857, USA
AD  - Division of Clinical Services and Research, National Institute on Drug Abuse, 5600 Fishers Ln, Rockville, MD 20857
U2  - PMID: 7745777.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Flynn, Patrick M.
AU  - Luckey, James W.
AU  - Brown, Barry S.
AU  - Hoffman, Jeffrey A.
AU  - Dunteman, George H.
AU  - Theisen, Anne C.
AU  - Hubbard, Robert L.
AU  - Needle, Richard
AU  - Schneider, Sid J.
AU  - Koman, III, Joseph J.
AU  - Atef-Vahid, Mohammad
AU  - Karson, Samuel
AU  - Palsgrove, Gary L.
AU  - Yates, Brian T.
T1  - Relationship between Drug Preference and Indicators of Psychiatric Impairment.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1995/06//
VL  - 21
IS  - 2
M3  - Article
SP  - 153
EP  - 166
SN  - 00952990
AB  - This study was conducted to investigate the relationship between the indicators of psychiatric disorders of individuals and their choice of either cocaine or heroin, drugs that differ markedly in their pharmacological effects. Cocaine acts as an intense stimulant, and heroin has profound sedative effects. This investigation examined the relationship between preference for heroin or cocaine and indicators of psychiatric impairment. Data from 282 subjects were grouped according to drug of choice and analyzed. Ninety-three percent of these subjects were African-American, 32% were female, and the average age was 34. Univariate and multivariate statistical analyses, such as discriminant analyses, were used to determine group differences. The results are evaluated and interpreted in relation to both the current empirical findings and to the hypotheses and theories postulated as a result of earlier clinical observations on drug of choice and psychopathology. Discriminant analysis yielded an overall correct classification rate of 75%. The discriminant function suggests that members in the cocaine drug of choice group as contrasted with members in the heroin preference group can be characterized as more socially inhibited and more self-defeating after adjusting for differences in age, duration of use of illicit substances, and marital status. Those who favored cocaine as contrasted with those who favored heroin were more likely to have never married, be younger, and have used illicit substances for a shorter period of time. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse
KW  - PSYCHIATRIC diagnosis
KW  - COCAINE abuse
KW  - HEROIN
KW  - SEDATIVES
KW  - PATHOLOGICAL psychology
N1  - Accession Number: 9508223632; Flynn, Patrick M. 1 Luckey, James W. 1 Brown, Barry S. 2 Hoffman, Jeffrey A. 3 Dunteman, George H. 1 Theisen, Anne C. 1 Hubbard, Robert L. 1 Needle, Richard 4 Schneider, Sid J. 3 Koman, III, Joseph J. 3 Atef-Vahid, Mohammad 3 Karson, Samuel 5 Palsgrove, Gary L. 4 Yates, Brian T. 6; Affiliation:  1: Substance Abuse Treatment Research Program, Research Triangle Institute, Research Triangle Park, North Carolina.  2: University of North Carolina, Wilmington Wilmington, North Carolina.  3: Koba Associates, Inc. Washington, D.C.  4: National Institute on Drug Abuse Rockville, Maryland.  5: Second Genesis, Inc. Bethesda, Maryland.  6: Institutes for Behavior Resources, Inc. Washington, D.C.; Source Info: Jun95, Vol. 21 Issue 2, p153; Subject Term: DRUG abuse; Subject Term: PSYCHIATRIC diagnosis; Subject Term: COCAINE abuse; Subject Term: HEROIN; Subject Term: SEDATIVES; Subject Term: PATHOLOGICAL psychology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 14p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Janerich, Dwight T.
AU  - Hadjimichael, Olympia
AU  - Schwartz, Peter E.
AU  - Lowell, David M.
AU  - Meigs, J. Wister
AU  - Merino, Maria J.
AU  - Flannery, John T.
AU  - Polednak, Anthony P.
T1  - The Screening Histories of Women with Invasive Cervical Cancer, Connecticut.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/06//
VL  - 85
IS  - 6
M3  - Article
SP  - 791
EP  - 794
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Each case of a continuous series of invasive cervical cancer cases was studied with a structured review procedure conducted by an expert panel to asses the reason that it was not detected before it became invasive. Methods. All cases of invasive cervical cancer diagnosed in a 5-year period among Connecticut residents were identified; a screening history and screening outcome were obtained for 72% (481 of 664). Results. Two hundred fifty women (51.9%) had suboptimal screening. One hundred thirty-seven women (28.5%) had never had a screening test, and their mean age was greater than that of the rest of the study population (64.5 year vs 46.5 years). Of the 344 women who had ever had a Pap test, 113 (32.8%) had their last Pap test 5 or more years before their diagnosis of invasive cancer; 52 (15.1%) were not followed up properly; 33 (9.6%) had their last smear misread as normal; and 118 (34.3%) developed cervical cancer within 3 yeas of their last Pap test. Conclusions. Physicians, nurses, and other care providers need to ensure that woman have timely and accurate screening with proper follow-up, make increased efforts to reach older women, and improve quality control of Pap smear readings. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CERVICAL cancer
KW  - CANCER invasiveness
KW  - WOMEN -- Diseases
KW  - CANCER -- Diagnosis
KW  - DIAGNOSIS
KW  - CONNECTICUT
N1  - Accession Number: 9506200477; Janerich, Dwight T. 1,2 Hadjimichael, Olympia 3 Schwartz, Peter E. 3 Lowell, David M. 3 Meigs, J. Wister 3 Merino, Maria J. 4 Flannery, John T. 5 Polednak, Anthony P. 5; Affiliation:  1: Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah  2: Foundation for Blood Research, Scarborough, Maine  3: Yale University, New Haven, Conn  4: National Cancer Institute, Bethesda, Md  5: Connecticut Department of Public Health and Addiction Services, Hartford, Conn; Source Info: Jun95, Vol. 85 Issue 6, p791; Subject Term: CERVICAL cancer; Subject Term: CANCER invasiveness; Subject Term: WOMEN -- Diseases; Subject Term: CANCER -- Diagnosis; Subject Term: DIAGNOSIS; Subject Term: CONNECTICUT; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Piscitelli, S. C.;
T1  - Pharmacology of antimycobacterial drugs: practical aspects
CT  - Pharmacology of antimycobacterial drugs: practical aspects
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1995/06/01/
VL  - 52
IS  - Jun
SP  - PI
EP  - 19
AD  - National Institutes of Health, Clinical Center, Bldg. 10, Room 1 N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 32-04943; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - The selection of an appropriate drug regimen for tuberculosis involves a variety of factors. Multidrug-resistant strains of Mycobacterium tuberculosis have altered the traditional approach to therapy; 2nd line drugs now play a much larger role and 4- and 5-drug regimens may be required. Since AIDS patients demonstrate an increased incidence of drug-related adverse effects, it is important to select agents which are both efficacious and have minimal overlapping toxicities. Additional concerns with multidrug regimens include the increased potential for noncompliance and drug interactions. A percentage of AIDS patients with tuberculosis have malabsorption of antimycobacterial drugs, possibly due to gastrointestinal effects of AIDS. Thus, a combination of parenteral and oral therapy may help to ensure adequate blood concentrations. In cases of treatment failure, therapeutic drug monitoring may be an option. This lecture will provide the audience with an overview of practical aspects f drug regimen design for the AIDS patient with tuberculosis. Learning objectives: 1. List pertinent clinical aspects in selecting antitubercular drug regimens. 2. Describe therapeutic drug monitoring and outcome parameters in treating tuberculosis. 3. Describe promising new strategies and delivery systems under evaluation for managing tuberculosis, especially multidrug-resistant infection. Self-assessment questions: 1. Which of the following reflects recent observations on the absorption of antitubercular drugs in AIDS patients? A. Malabsorption occurs in a subset of patients. B. Increased absorption occurs leading to toxicity. C. No differences are apparent between AIDS and non-AIDS patient. D. No data is available on drug absorption in AIDS patients. 2. Which of the following pairs of drugs have overlapping hepatotoxicity? A. Ethambutol and cycloserine. B. Streptomycin and pyrazinamide. C. Rifampin and isoniazid. D. None of the above. 3. Treatment failure in AIDS patients with tuberculosis may be due to: A. Noncompliance. B. Multi-drug resistance. C. Malabsorption. D. All of the above. Answers: 1 (A), 2 (C), 3 (D)
KW  - ASHP meeting abstracts--mycobacterium infections;
KW  - Antituberculars--tuberculosis--HIV infections;
KW  - Resistance--antituberculars--tuberculosis, HIV infections;
KW  - Tuberculosis--antituberculars--HIV infections;
KW  - Acquired immunodeficiency syndrome--antituberculars--tuberculosis therapy;
KW  - Absorption--antituberculars--AIDS;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Minor, J. R.;
T1  - Tuberculosis: re-emergence of an old killer
CT  - Tuberculosis: re-emergence of an old killer
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1995/06/01/
VL  - 52
IS  - Jun
SP  - PI
EP  - 17
AD  - National Institutes of Health, Clinical Center, Bldg. 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 32-04944; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - This session will provide an introductory overview of the re-emergence of Mycobacterium tuberculosis as a major opportunistic infection, its clinical features, and current management guidelines. Public health issues relating to transmission of tuberculosis and emergence of multidrug-resistant tuberculosis will also be discussed. Learning objectives: 1. Describe the clinical, laboratory and immunological features of tuberculosis. 2. Describe factors contributing to the increase in multidrug-resistant tuberculosis. 3. List containment methods for controlling the transmission of tuberculosis in health care institutional settings. Self-assessment questions: 1. HIV is considered a major risk factor for the progression of latent \IT/M. tuberculosis\OK/ infection to active TB. 2. Progressive HIV-induced CD8+ T-lymphocyte depletion leads to a defective immunological response to \IT/M. tuberculosis\OK/ and to an increased risk of active disease. 3. Use of negative pressure isolation rooms, ultraviolet germicidal irradiation, and high efficiency particulate air filtration are selected methods of preventing TB transmission within institutional settings. Answers 1. (T); 2. (F); 3. (T).
KW  - ASHP meeting abstracts--tuberculosis;
KW  - Protocols--antituberculars--tuberculosis;
KW  - Antituberculars--tuberculosis--resistance;
KW  - HIV infections--antituberculars--tuberculosis therapy;
KW  - Public health--tuberculosis--resistance;
KW  - Resistance--antituberculars--tuberculosis;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Yu, Kai Fun
T1  - A necessary and sufficient condition for the strong consistency of a family of estimators of the common odds ratio.
JO  - Canadian Journal of Statistics
JF  - Canadian Journal of Statistics
Y1  - 1995/06//
VL  - 23
IS  - 2
M3  - Article
SP  - 215
EP  - 225
SN  - 03195724
AB  - The article proposes a family of estimators of the odds ratio of a number of two-by-two contingency tables. Using the Mantel-Haenszel estimator, the author questions the validity of Breslow's condition for consistency and asymptotic normality. Based on some examples, the author found that Breslow's condition is neither necessary nor sufficient for Mantel-Haenszel estimator's consistency.
KW  - ESTIMATION theory
KW  - RATIO & proportion
KW  - CONTINGENCY tables
KW  - MATHEMATICAL statistics
KW  - STATISTICAL hypothesis testing
N1  - Accession Number: 61887904; Yu, Kai Fun 1; Affiliation:  1: Division of Epidemiology, Statistics and Prevention Research National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland 20892, U.S.A.; Source Info: Jun1995, Vol. 23 Issue 2, p215; Subject Term: ESTIMATION theory; Subject Term: RATIO & proportion; Subject Term: CONTINGENCY tables; Subject Term: MATHEMATICAL statistics; Subject Term: STATISTICAL hypothesis testing; Number of Pages: 11p; Document Type: Article
L3  - 10.2307/3315446
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=61887904&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - O'Hanlon, T. P.
AU  - Messersmith, W. A.
AU  - Dalakas, M. C.
AU  - Plot, P. H.
AU  - Miller, F. W.
T1  - γδ T cell receptor gene expression by muscle-infiltrating lymphocytes in the idiopathic inflammatory myopathies.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1995/06//
VL  - 100
IS  - 3
M3  - Article
SP  - 519
EP  - 528
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Autoreactive αβ T cells have been implicated as playing a primary pathogenic role in a group of diseases characterized by chronic muscle inflammation known as the idiopathic inflammatory myopathies (IIM). γδ T cells, a distinct and enigmatic class of 'T cells, play a less certain role in a variety of human autoimmune diseases including the IIM. In an attempt to understand the significance of γδ T cells in the IIM, we utilized a sensitive polymerase chain reaction (PCR) technique to evaluate γδ T cell receptor (TCR) gene expression in 45 muscle biopsies obtained from 42 IIM patients (17 polymyositis. 12 dermatomyositis, and 13 inclusion body myositis). γδ TCR gene expression was not detected in 36 specimens, the majority of muscle biopsies surveyed. γδ TCR gene expression by muscle-infiltrating lymphocytes was detected among nine clinically heterogeneous patients. We further analysed the functional sequence composition of the Vγ3 and Vδ1 transcripts, whose expression was prominent among γδ positive patients. DNA sequence analysis of Vγ3 amplification products from two patients revealed the presence of several productively rearranged transcripts with amino acid sequence similarities within the Vγ3-N-Jγ junctional domain. No amino acid sequence similarities were evident within the Vδ-N-Dδ-N-Jδ region of Vδ1 transcripts amplified from four patients, although a distinct and dominant clonotype was detected from each patient. Our cumulative data suggest that unlike αβ T cells, γδ T cells do not play a prominent pathologic role in the IIM. In fact, the sporadic nature of γδ TCR gene expression detected among these patients implies that γδ T cell infiltration, when it occurs, is a secondary event perhaps resulting from non-specific inflammatory processes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - CELL receptors
KW  - LYMPHOCYTES
KW  - INFLAMMATION
KW  - MUSCLES
KW  - POLYMYOSITIS
KW  - γ&delta T cells
KW  - myositis
KW  - T cell receptors
N1  - Accession Number: 16194786; O'Hanlon, T. P. 1 Messersmith, W. A. 1 Dalakas, M. C. 2 Plot, P. H. 3 Miller, F. W. 1; Affiliation:  1: Molecular Immunology Laboratory, Centre for Biologies Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA.  2: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.  3: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Jun1995, Vol. 100 Issue 3, p519; Subject Term: T cells; Subject Term: CELL receptors; Subject Term: LYMPHOCYTES; Subject Term: INFLAMMATION; Subject Term: MUSCLES; Subject Term: POLYMYOSITIS; Author-Supplied Keyword: γ&delta T cells; Author-Supplied Keyword: myositis; Author-Supplied Keyword: T cell receptors; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107425857
T1  - Delirium in palliative medicine.
AU  - Caraceni A
Y1  - 1995///1995 Summer
N1  - Accession Number: 107425857. Language: English. Entry Date: 19951101. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9434451. 
KW  - Terminally Ill Patients
KW  - Delirium -- Diagnosis
KW  - Delirium -- Etiology
KW  - Delirium -- Therapy
KW  - Risk Factors
KW  - Palliative Care
KW  - DSM
KW  - Delirium -- Chemically Induced
KW  - Sedation
SP  - 62
EP  - 67
JO  - European Journal of Palliative Care
JF  - European Journal of Palliative Care
JA  - EUR J PALLIAT CARE
VL  - 2
IS  - 2
PB  - Hayward Medical Communications
AB  - Augusto Caraceni stresses that accurate assessment of the patient is vital if treatment of delirium is to be successful: this includes discontinuing all non-essential drugs.
SN  - 1352-2779
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lazarova, Zelmira
AU  - Domloge-Hultsch, Nouha
AU  - Yancey, Kim B.
T1  - Epiligrin is decreased in papulonodular basal cell carcinoma tumor nest basement membranes and extracellular matrix of transformed human epithelial cells.
JO  - Experimental Dermatology
JF  - Experimental Dermatology
Y1  - 1995/06//
VL  - 4
IS  - 3
M3  - Article
SP  - 121
EP  - 129
SN  - 09066705
AB  - Patients with anti-epiligrin cicatricial pemphigoid have antibasement membrane autoantibodies that immunoprecipitate a set of disulfide-linked human keratinocyte polypeptides that co-migrate in sodium dodecyl sulfate polyacrylamide gel electrophoresis with the same complex identified by monoclonal anti-epiligrin (PIEI) and monoclonal anti-nicein/kalinin (GB3) antibodies. In an attempt to further compare the reactivity of patient autoantibodies. PIEI and GB3, these reagents were tested against the tumor nest basement membranes of 7 papulonodular basal cell carcinomas. These studies found that all of these reagents showed markedly decreased or no reactivity against this substrate. Though their concordant lack of reactivity failed to distinguish these antibodies, these studies did identify a significant defect in papulonodular basal cell carcinoma tumor nest basement membranes. Similarly, integrin subunits α[sub6], β[sub4], α[sub3], and α[sub2] as well as bullous pemphigoid antigens 1 and 2 (all potential receptors for the extracellular matrix ligands epiligrin and nicein/kalinin) were also reduced in these tumor nest basement membranes. These findings signify an extensive impairment in the lamina lucida of this neoplasm's basement membrane. Related comparative studies of normal human keratinocytes and transformed human epithelial cell lines (specifica!ly, A-431 and HaCat cells) showed that epiligrin production is markedly decreased in the latter. Decreased expression of epiligrin and nicein/kalinin in papulonodular basal cell carcinoma tumor nest basement membranes in vivo and transformed epithelial cells in vitro indicate that this complex is a transformation-sensitive cell adhesion ligand. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL cell carcinoma
KW  - INTEGRINS
KW  - SKIN -- Cancer
KW  - EPITHELIUM
KW  - GLYCOPROTEINS
KW  - CELL adhesion molecules
KW  - epiligrin - basal cell carcinoma - integrins
N1  - Accession Number: 11698585; Lazarova, Zelmira 1 Domloge-Hultsch, Nouha 2 Yancey, Kim B. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health  2: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A.; Source Info: Jun95, Vol. 4 Issue 3, p121; Subject Term: BASAL cell carcinoma; Subject Term: INTEGRINS; Subject Term: SKIN -- Cancer; Subject Term: EPITHELIUM; Subject Term: GLYCOPROTEINS; Subject Term: CELL adhesion molecules; Author-Supplied Keyword: epiligrin - basal cell carcinoma - integrins; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1600-0625.ep11698585
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107334691
T1  - Recognition and treatment of obsessive-compulsive disorder.
AU  - Altemus M
AU  - Greenberg BD
AU  - Murphy DL
Y1  - 1995/06//1995 Jun
N1  - Accession Number: 107334691. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0373017. 
KW  - Obsessive-Compulsive Disorder
KW  - Education, Continuing (Credit)
KW  - Obsessive-Compulsive Disorder -- Symptoms
KW  - Obsessive-Compulsive Disorder -- Diagnosis
KW  - Obsessive-Compulsive Disorder -- Therapy
KW  - Diagnosis, Differential
SP  - 37
EP  - 54
JO  - Hospital Medicine
JF  - Hospital Medicine
JA  - HOSP MED
VL  - 31
IS  - 6
CY  - Parsippany, New Jersey
PB  - Frontline Medical Communications
AB  - The symptoms of OCD, which affects 4 to 6 million people in the US, often go unrecognized by the primary care physician. Treatment with a specific subset of antidepressant agents controls the disorder in most patients.
SN  - 0441-2745
AD  - OCD Research Unit, National Institute of Mental Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Duyn, Jeff H.
AU  - Frank, Joseph A.
AU  - Ramsey, Nick R.
AU  - Mattay, Venkata S.
AU  - Sexton, Roy H.
AU  - Tallent, Kathleen A.
AU  - Moonen, Chrit T. W.
AU  - Van Gelderen, Peter
AU  - Weinberger, Daniel R.
T1  - Effects of Large Vessels in Functional Magnetic Resonance Imaging at 1.5 T.
JO  - International Journal of Imaging Systems & Technology
JF  - International Journal of Imaging Systems & Technology
Y1  - 1995///Summer-Fall95
VL  - 6
IS  - 2/3
M3  - Article
SP  - 245
EP  - 252
SN  - 08999457
AB  - To further investigate the effects of large vessels on the activation maps generated with functional magnetic resonance imaging at 1.5 T, we studied activation of the human visual and motor cortex using a multitude of dedicated FLASH and echo-planar imaging (EPI) scanning techniques. Both slice and volume scans were performed to assess relative contributions of T2- effects, in-flow, and phase-shift effects, specifically within and around the larger vessels (around 1 mm in diameter). The contrast mechanism in single-slice FLASH studies appeared to be predominantly sensitive to in-flow and phase effects of the blood water within these larger vessels, and their relative contributions were dependent on experimental parameters and vascular geometry. The contrast mechanism in gradient echo EPI studies was governed predominantly by T2- effects in tissue water (and to a lesser extent cerebrospinal fluid) surrounding the larger vessels. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Imaging Systems & Technology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAGNETIC resonance imaging
KW  - BRAIN mapping
KW  - BRAIN function localization
KW  - DIAGNOSTIC imaging
KW  - IMAGING systems in medicine
KW  - IMAGE processing
N1  - Accession Number: 14184337; Duyn, Jeff H. 1 Frank, Joseph A. 1 Ramsey, Nick R. 2 Mattay, Venkata S. 2 Sexton, Roy H. 2 Tallent, Kathleen A. 2 Moonen, Chrit T. W. 3 Van Gelderen, Peter 3 Weinberger, Daniel R.; Affiliation:  1: Laboratory of Diagnostic Radiology Research, OD-OlR, Building 10, Room B1N-256, National Institutes of Health, Bethesda, MD 20892  2: Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892  3: National Institutes of Health In Vivo NMR Research Center, Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, MD 20892; Source Info: Summer-Fall95, Vol. 6 Issue 2/3, p245; Subject Term: MAGNETIC resonance imaging; Subject Term: BRAIN mapping; Subject Term: BRAIN function localization; Subject Term: DIAGNOSTIC imaging; Subject Term: IMAGING systems in medicine; Subject Term: IMAGE processing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 812922 One-Hour Photofinishing; NAICS/Industry Codes: 812921 Photofinishing Laboratories (except One-Hour); Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105854115
T1  - Suicide in late life: challenges and opportunities for research. Introduction.
AU  - Pearson JL
AU  - Conwell Y
AU  - Pearson, J L
AU  - Conwell, Y
Y1  - 1995/06//6/ 1/1995
N1  - Accession Number: 105854115. Language: English. Entry Date: 20080314. Revision Date: 20161117. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007918. 
KW  - Evaluation Research
KW  - Suicide
KW  - Age Factors
KW  - Aged
KW  - Female
KW  - Male
KW  - Public Health
KW  - Sex Factors
KW  - Study Design
KW  - Human
SP  - 131
EP  - 136
JO  - International Psychogeriatrics
JF  - International Psychogeriatrics
JA  - INT PSYCHOGERIATR
PB  - Cambridge University Press
SN  - 1041-6102
AD  - Mental Disorders of the Aging Research Branch, National Institute of Mental Health, Rockville, Maryland, USA
AD  - Mental Disorders of the Aging Research Branch, National Institute of Mental Health, Rockville, Maryland, USA.
U2  - PMID: 8829422.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854116
T1  - Epidemiology of suicide.
AU  - Moscicki EK
AU  - Mościcki, E K
Y1  - 1995/06//6/ 1/1995
N1  - Accession Number: 105854116. Language: English. Entry Date: 20080314. Revision Date: 20161117. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007918. 
KW  - Suicide -- Epidemiology
KW  - Suicide -- Prevention and Control
KW  - Age Factors
KW  - Aged
KW  - Death
KW  - Risk Factors
KW  - United States
SP  - 137
EP  - 148
JO  - International Psychogeriatrics
JF  - International Psychogeriatrics
JA  - INT PSYCHOGERIATR
PB  - Cambridge University Press
AB  - This article presents the epidemiology of suicide with a special focus on suicides among the elderly, and discusses the known risk factors for suicide within a framework designed to encourage a systematic approach to theory testing and prevention. Throughout the world, suicide rates are highest among the elderly. The risk factors for suicide can be classified as distal or proximal, and, within these broad categories, as sociodemographic, psychiatric, biological, familial, and situational. Mental and addictive disorders are the major risk factors for suicide in all age groups. Other risk factors include male gender, disrupted marital status, prior suicide attempt, reduced brain stem serotonergic activity, family history of psychiatric disorder or suicide, a firearm in the home, and a recent, severely stressful life event. Since risk factors for suicide rarely occur in isolation, prevention efforts are more likely to succeed if multiple risk factors are targeted.
SN  - 1041-6102
AD  - Prevention Research Branch, National Institute of Mental Health, Rockville, MD 20857, USA
AD  - Prevention Research Branch, National Institute of Mental Health, Rockville, MD 20857, USA.
U2  - PMID: 8829423.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kraerner, Kenneth H.
T1  - Are People Who Get Skin Cancer Different?
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/06//
VL  - 104
IS  - 6
M3  - Article
SP  - 887
EP  - 888
SN  - 0022202X
AB  - This year nearly 1 million people in the U.S. will develop non-melanoma skin cancer. This is by far the most common neoplasm in Caucasians. The cumulative lifetime risk is greater than 15 percent. For many years epidemiologic studies have examined risk factors for development of non-melanoma skin cancer. Numerous environmental and genetic factors have been considered. Inhabitants of areas with high solar radiation such as New Mexico or Australia have a high frequency of skin cancer. A few genetic diseases, such as nevoid basal cell carcinoma syndrome and xeroderma pigmentosum, have a greatly increased risk of non-melanoma skin cancer.
KW  - SKIN -- Cancer
KW  - CAUCASIAN race
KW  - XERODERMA pigmentosum
KW  - MELANOMA
KW  - PHOTOSENSITIVITY disorders
KW  - UNITED States
N1  - Accession Number: 12606156; Kraerner, Kenneth H. 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun95, Vol. 104 Issue 6, p887; Subject Term: SKIN -- Cancer; Subject Term: CAUCASIAN race; Subject Term: XERODERMA pigmentosum; Subject Term: MELANOMA; Subject Term: PHOTOSENSITIVITY disorders; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article
L3  - 10.1111/1523-1747.ep12606156
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sato, Chiyo
AU  - Tsuboi, Ryoji
AU  - Shi, Chong-Ming
AU  - Rubin, Jeffrey S.
AU  - Ogawa, Hideoki
T1  - Comparative Study of Hepatocyte Growth Factor/ Scatter Factor and Keratinocyte Growth Factor Effects on Human Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/06//
VL  - 104
IS  - 6
M3  - Article
SP  - 958
EP  - 963
SN  - 0022202X
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) and keratinocyte growth factor (KGF, also designated FGF-7) are paracrine growth factors secreted by mesenchymal cells and active on a variety of epithelial cell types. In this study, the biologic response of keratinocytes to these paracrine growth factors were compared. Stimulation of mitogenesis, migration, plasminogen activator (PA) activity, and fibronectin production were examined using human foreskin keratinocytes cultured in serum-free MCDB 153 medium. Although the two factors stimulated a similar level of proliferation when cells were maintained for 5 d in 1.8 mM Ca++, the peak effect of KGF, observed at 10 ng/ml, was approximately threefold higher than that of HGF/SF when cells were in medium containing 0.15 mM Ca++. Both agents promoted the migration of cells in low-calcium medium (0.08 mM Ca++). However, the magnitude of the response was approximately twofold greater for HGF/SF at 10 ng/ml than KGF at the same concentration. None of the matrix proteins such as type I collagen, type IV collagen, laminin, or fibronectin either stimulated or supressed HGF/SF-or KGF-stimulated kerationocyte migration. Both factors stimulated PA activity was maximal with the addition of 10 ng/ml of either factor. Neither factor increased the production of fibronectin under conditions in which transforming growth factor-β1 was active. These results indicate that HGF/SF and KGF, both recognized as paracrine growth factors, elicit distinctive patterns of response by keratinocytes, implying that they have different roles in epidermal physiology. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - HEPATOCYTE growth factor
KW  - FIBRONECTINS
KW  - PLASMINOGEN activators
KW  - GLYCOPROTEINS
KW  - PROTEOLYTIC enzymes
KW  - <em>fibronectin</em>
KW  - <em>Migration</em>
KW  - <em>plasminogen activator.</em>
N1  - Accession Number: 12606221; Sato, Chiyo 1 Tsuboi, Ryoji 1 Shi, Chong-Ming 1 Rubin, Jeffrey S. 2 Ogawa, Hideoki 1; Affiliation:  1: Department of Dermatology, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan  2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jun95, Vol. 104 Issue 6, p958; Subject Term: KERATINOCYTES; Subject Term: HEPATOCYTE growth factor; Subject Term: FIBRONECTINS; Subject Term: PLASMINOGEN activators; Subject Term: GLYCOPROTEINS; Subject Term: PROTEOLYTIC enzymes; Author-Supplied Keyword: <em>fibronectin</em>; Author-Supplied Keyword: <em>Migration</em>; Author-Supplied Keyword: <em>plasminogen activator.</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12606221
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yancey, Kim B.
T1  - Adhesion Molecules. II: Interactions of Keratinocytes with Epidermal Basement Membrane.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/06//
VL  - 104
IS  - 6
M3  - Article
SP  - 1008
EP  - 1014
SN  - 0022202X
AB  - Interconnections between keratin intermediate filaments and hemidesmosomes in basal keratinocytes, anchoring filaments and macromolecules in lamina lucida, a network of structural proteins in lamina densa, and anchoring fibrils and interstitial collagen fibrils in papillary dermis form a continuous unit that promotes adhesion of keratinocytes to epidermal basement membrane (BM). Laminin 5 is a recently identified laminin isoform that is present in BM of stratified epithelia in skin, trachea, eosophagus, cornea, amnion, and the gastrointestinal tract. In human epidermal BM, laminin 5 has been localized to anchoring filaments.
KW  - KERATINOCYTES
KW  - BASAL lamina
KW  - HEMIDESMOSOMES
KW  - CYTOSKELETAL proteins
KW  - EPITHELIAL cells
KW  - CELLS
N1  - Accession Number: 12606244; Yancey, Kim B. 1; Affiliation:  1: Senior Investigator, Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun95, Vol. 104 Issue 6, p1008; Subject Term: KERATINOCYTES; Subject Term: BASAL lamina; Subject Term: HEMIDESMOSOMES; Subject Term: CYTOSKELETAL proteins; Subject Term: EPITHELIAL cells; Subject Term: CELLS; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12606244
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Legler, Julie M.
AU  - Lefkopoulou, Myrto
AU  - Ryan, Louise M.
T1  - Efficiency and Power of Tests for Multiple Binary Outcomes.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1995/06//
VL  - 90
IS  - 430
M3  - Article
SP  - 680
EP  - 693
SN  - 01621459
AB  - Global tests provide a useful tool for comparing two or more groups with respect to multiple correlated outcomes. We adapt and compare the performance of tests that have been suggested for use with multiple continuous outcomes to the case of multiple binary outcomes. Comparisons and guidelines are based on asymptotic relative efficiencies (ARE's) and simulations. These results are illustrated using an application from teratology. We extend the work of Lefkopoulou and Ryan to include general M-group comparisons alternatives where group effects may differ for each outcome. A concise form for this general class of score tests is derived. To compute the ARE's for this class of tests, we devise a useful characterization of the alternative space based on multivariate polar coordinates. Our findings indicate that the common outcome effect tests are efficient for a remarkably large range of circumstances. A simple formula applies to compute the maximum number of unaffected outcomes that can be included in a set of outcomes for which the common outcome effect tests remain more efficient than those derived under multidimensional alternatives. For comparison, other global tests are also considered in the simulations: two tests based on resampling (maximal and minimal z tests), a rank-sum test, a generalized least squares test, and a test based on collapsing multiple endpoints to a single binary outcome. Besides the common outcome effect tests, the resampling tests and the rank-sum test are found to perform very well for the cases under consideration. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CORRELATION (Statistics)
KW  - ESTIMATION theory
KW  - MATHEMATICAL statistics
KW  - SIMULATION methods & models
KW  - ASYMPTOTIC efficiencies (Statistics)
KW  - LEAST squares
KW  - Generalized estimating equations
KW  - Multiple binary endpoints
KW  - Pit man asymptotic relative efficiencies
KW  - Score tests
N1  - Accession Number: 9506230528; Legler, Julie M. 1; Lefkopoulou, Myrto; Ryan, Louise M. 2; Affiliations: 1: Intramural Research Fellow, National Institutes of Health, NICHD, Bethesda, MD 20892.; 2: Associate Professor, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.; Issue Info: Jun95, Vol. 90 Issue 430, p680; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: ESTIMATION theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: SIMULATION methods & models; Subject Term: ASYMPTOTIC efficiencies (Statistics); Subject Term: LEAST squares; Author-Supplied Keyword: Generalized estimating equations; Author-Supplied Keyword: Multiple binary endpoints; Author-Supplied Keyword: Pit man asymptotic relative efficiencies; Author-Supplied Keyword: Score tests; Number of Pages: 14p; Illustrations: 1 Diagram, 4 Charts, 22 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Albert, Paul S.
AU  - Lange, Nicholas
T1  - Random Coefficient Models.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1995/06//
VL  - 90
IS  - 430
M3  - Book Review
SP  - 801
EP  - 802
SN  - 01621459
AB  - Reviews the book "Random Coefficient Models," by Nicholas T. Longford.
KW  - MULTILEVEL models (Statistics)
KW  - NONFICTION
KW  - LONGFORD, Nicholas T.
KW  - RANDOM Coefficient Models (Book)
N1  - Accession Number: 9506230545; Albert, Paul S. 1; Lange, Nicholas 1; Affiliations: 1: The National Institutes of Health.; Issue Info: Jun95, Vol. 90 Issue 430, p801; Subject Term: MULTILEVEL models (Statistics); Subject Term: NONFICTION; Reviews & Products: RANDOM Coefficient Models (Book); People: LONGFORD, Nicholas T.; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Lange, Nicholas
T1  - Statistical Analysis of Circular Data.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1995/06//
VL  - 90
IS  - 430
M3  - Book Review
SP  - 801
EP  - 801
SN  - 01621459
AB  - Reviews the book "Statistical Analysis of Circular Data," by Nicholas I. Fisher.
KW  - CIRCULAR data
KW  - NONFICTION
KW  - FISHER, Nicholas I.
KW  - STATISTICAL Analysis of Circular Data (Book)
N1  - Accession Number: 9506230544; Lange, Nicholas 1; Affiliations: 1: National Institutes of Health.; Issue Info: Jun95, Vol. 90 Issue 430, p801; Subject Term: CIRCULAR data; Subject Term: NONFICTION; Reviews & Products: STATISTICAL Analysis of Circular Data (Book); People: FISHER, Nicholas I.; Number of Pages: 1/2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107355285
T1  - A review of infertility and its treatment in the etiology of female reproductive and other cancers.
AU  - Ron E
AU  - Lunenfeld B
Y1  - 1995/06//1995 Jun
N1  - Accession Number: 107355285. Language: English. Entry Date: 19960101. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Infertility -- Complications
KW  - Neoplasms -- Etiology
KW  - Fertility Agents -- Adverse Effects
KW  - Infertility -- Etiology
KW  - Breast Neoplasms
KW  - Endometrial Neoplasms
KW  - Ovarian Neoplasms
KW  - Parity
KW  - Infertility -- Epidemiology
KW  - Clomiphene
KW  - Gonadotropins, Pituitary
KW  - Female
SP  - 261
EP  - 272
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 4
IS  - 3
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - Although infertile women do not appear to have an increased risk of cancer when all sites are combined, nulliparity is associated with an increased risk of cancers of the breast, ovary, and endometrium; elevated risks of female reproductive cancers have been reported in some studies; and use of fertility drugs was found to significantly increase the risk of ovarian cancer in a pooled analysis of three case-control studies and in one cohort study. Because specific causes of infertility were not always classified precisely, fertility drugs were not evaluated in many studies, the number of cases is limited, and problems in separating effects of nulliparity, infertility, and fertility drug usage remain, these results should be interpreted cautiously. With an estimated 10% of couples unable to conceive and the use of fertility drugs increasing dramatically, there is a need to clarify the role of infertility and fertility drugs in the induction of cancer.
SN  - 1059-7115
AD  - Radiation Epidemiology Branch National Cancer Institute, National Institute of Health, Executive Plaza North, Room 408, 6130 Executive Blvd., Rockville, MD 20852
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - 
AU  - Westergaard, Gregory Charles1
AU  - Shennan, Stephen
T1  - The stone-tool technology of capuchin monkeys: Possible implications for the evolution of...
JO  - World Archaeology
JF  - World Archaeology
J1  - World Archaeology
PY  - 1995/06//
Y1  - 1995/06//
VL  - 27
IS  - 1
CP  - 1
M3  - Article
SP  - 1
EP  - 9
SN  - 00438243
AB  - Research with captive capuchin monkeys has demonstrated that these New World primates produce flaked stone artifacts that they use as cutting tools, and that they exhibit patterns of right-handedness analogous to those of tool-making Plio-Pleistocene hominids. These findings indicate that the cognitive and biomechanical conditions of pre-adaptation for the production and use of stone tools are present in extant nonhuman primates, and that capuchins can be used to model processes associated with the evolution of technology and symbolic communication in humans. [ABSTRACT FROM AUTHOR]
KW  - Tool use in animals
KW  - Stone-cutting tools
KW  - Capuchin
KW  - Cebus
KW  - evolution
KW  - hominid
KW  - language
KW  - tool use
N1  - Accession Number: 9508214389; Authors: Westergaard, Gregory Charles 1; Shennan, Stephen; Affiliations:  1: Laboratory of Comparative Ethology National Institute of Child Health and Human Development Poolesville, MD; Subject: Tool use in animals; Subject: Stone-cutting tools; Author-Supplied Keyword: Capuchin; Author-Supplied Keyword: Cebus; Author-Supplied Keyword: evolution; Author-Supplied Keyword: hominid; Author-Supplied Keyword: language; Author-Supplied Keyword: tool use; Number of Pages: 9p; Illustrations: 5 Black and White Photographs; Record Type: Article; Full Text Word Count: 3538
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DP  - EBSCOhost
DB  - asu
ER  - 

TY  - JOUR
ID  - 107392197
T1  - Biologic and molecular prognostic factors -- impact on treatment of patients with non-small cell lung cancer.
AU  - Johnson BE
Y1  - 1995/06/02/1995 Jun Suppl
N1  - Accession Number: 107392197. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; pictorial; review; tables/charts. Supplement Title: 1995 Jun Suppl. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0231335. 
KW  - Carcinoma -- Metabolism
KW  - Growth Substances -- Metabolism
KW  - Lung Neoplasms -- Metabolism
KW  - Tumor Markers, Biological -- Metabolism
KW  - Carcinoma -- Familial and Genetic
KW  - Carcinoma -- Mortality
KW  - Carcinoma -- Therapy
KW  - Genes
KW  - Lung Neoplasms -- Familial and Genetic
KW  - Lung Neoplasms -- Mortality
KW  - Lung Neoplasms -- Therapy
KW  - Prognosis
KW  - Survival
SP  - 287S
EP  - 90S
JO  - CHEST
JF  - CHEST
JA  - CHEST
VL  - 107
IS  - 6
CY  - Glenview, Illinois
PB  - American College of Chest Physicians
AB  - A wide range of genetic and phenotypic abnormalities have been identified in lung cancer. However, only a few are known to have an impact on patient outcome and thus may influence choice of therapy. Biologic and molecular factors known in this regard include the epidermal growth factor family and its receptors, markers of neuroendocrine differentiation in non-small cell lung cancer, and mutations of the ras gene family. None of these factors, however, can be considered a standard for selection of patients for therapy until additional information is gleaned from ongoing prospective studies.
SN  - 0012-3692
AD  - Lung Cancer Biology Section, National Cancer Institute-Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, Md
U2  - PMID: 7781407.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854669
T1  - Lung cancer in radon-exposed miners and estimation of risk from indoor exposure.
AU  - Lubin JH
AU  - Boice JD Jr
AU  - Edling C
AU  - Hornung RW
AU  - Howe GR
AU  - Kunz E
AU  - Kusiak RA
AU  - Morrison HI
AU  - Radford EP
AU  - Samet JM
Y1  - 1995/06/07/
N1  - Accession Number: 105854669. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Air Pollution, Indoor -- Adverse Effects
KW  - Lung Neoplasms -- Chemically Induced
KW  - Occupational Exposure -- Adverse Effects
KW  - Radon -- Adverse Effects
KW  - Adult
KW  - Aged
KW  - Demography
KW  - Lung Neoplasms -- Mortality
KW  - Male
KW  - Middle Age
KW  - Mining
KW  - Relative Risk
KW  - Smoking
KW  - Time Factors
KW  - Human
SP  - 817
EP  - 827
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 11
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, Md 20892-7368, USA.
U2  - PMID: 7791231.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854669&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854675
T1  - Oral contraceptives and breast cancer risk among younger women.
AU  - Brinton LA
AU  - Daling JR
AU  - Liff JM
AU  - Schoenberg JB
AU  - Malone KE
AU  - Stanford JL
AU  - Coates RJ
AU  - Gammon MD
AU  - Hanson L
AU  - Hoover RN
Y1  - 1995/06/07/
N1  - Accession Number: 105854675. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Chemically Induced
KW  - Contraceptives, Oral -- Adverse Effects
KW  - Adult
KW  - Breast Neoplasms -- Pathology
KW  - Carcinoma in Situ -- Chemically Induced
KW  - Case Control Studies
KW  - Female
KW  - Logistic Regression
KW  - Neoplasm Invasiveness
KW  - Relative Risk
KW  - Risk Factors
KW  - Time Factors
KW  - Human
SP  - 827
EP  - 835
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 11
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 7791232.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854675&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854672
T1  - Mutagens from heated Chinese and U.S. cooking oils.
AU  - Shields PG
AU  - Xu GX
AU  - Blot WJ
AU  - Fraumeni JF Jr
AU  - Trivers GE
AU  - Pellizzari ED
AU  - Qu YH
AU  - Gao YT
AU  - Harris CC
Y1  - 1995/06/07/
N1  - Accession Number: 105854672. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Essential Oils -- Adverse Effects
KW  - Fatty Acids -- Adverse Effects
KW  - Heat
KW  - Lung Neoplasms -- Chemically Induced
KW  - Mutagens
KW  - China
KW  - Cooking
KW  - Female
KW  - Lung Neoplasms -- Epidemiology
KW  - Mass Spectrometry
KW  - Time Factors
KW  - United States
SP  - 836
EP  - 841
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 11
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Md 20892, USA.
U2  - PMID: 7791233.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Tiandra, Nico
AU  - Kuboniwa, Hiroshi
AU  - Ren, Hao
AU  - Bax, Ad
T1  - Rotational dynamics of calcium-free calmodulin studied by 15N-NMR relaxation measurements.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/06/15/
VL  - 230
IS  - 3
M3  - Article
SP  - 1014
EP  - 1024
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The backbone motions of calcium-free Xenopus calmodulin have been characterized by measurements of the 15N longitudinal relaxation times (T1) at 51 and 61 MHz, and by conducting transverse relaxation (T2), spin-locked transverse relaxation (Tp), and 15-{N-I¹H} heteronuclear NOE measurements at 61 MHz 15N frequency. Although backbone amide hydrogen exchange experiments indicate that the N-terminal domain is more stable than calmodulin's C-terminal half, slowly exchanging backbone amide protons are found in all eight a helices and in three of the four short β-strands. This confirms that the calcium-free form consists of stable secondary structure and does not adopt a ‘molten globule’ type of structure. However, the C-terminal domain of calmodulin is subject to conformational exchange on a time scale of about 350 μs, which affects many of the C-terminal domain residues. This results in significant shortening of the 15N T2 values relative to T1p whereas the T1p and T2 values are of similar magnitude in the N-terminal half of the protein. A model in which the motion of the protein is assumed to be isotropic suggests a rotational correlation time for the protein of about 8 ns but quantitatively does not agree with the magnetic field dependence of the T1 values and does not explain the different T2 values found for different α-helices in the N terminal domain. These latter parameters are compatible with a flexible dumbbell model in which each of calmodulin's two domains freely diffuse in a cone with a semi-angle of about 30° and a time constant of about 3 ns. whereas the overall rotation of the protein occurs on a much slower time scale of about 12 ns. The difference in the transverse relaxation rates observed between the amides in helices C and D suggests that the change in interhelical angle upon calcium binding is less than predicted by Herzberg et al. Strynadka and James [Strynadka, N. C. J. & James, M. N. G. (1988) Proteins Struct. Funct. Genet. 3, 1–17]. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALMODULIN
KW  - CALCIUM
KW  - RELAXATION (Health)
KW  - MAGNETIC fields
KW  - HYDROGEN
KW  - PROTONS
KW  - PROTEINS
KW  - 15n relaxation
KW  - calmodulin
KW  - domain motion
KW  - nmr
KW  - protein dynamics
N1  - Accession Number: 13561836; Tiandra, Nico 1 Kuboniwa, Hiroshi 1 Ren, Hao 2 Bax, Ad 1; Affiliation:  1: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA  2: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Source Info: 6/15/95, Vol. 230 Issue 3, p1014; Subject Term: CALMODULIN; Subject Term: CALCIUM; Subject Term: RELAXATION (Health); Subject Term: MAGNETIC fields; Subject Term: HYDROGEN; Subject Term: PROTONS; Subject Term: PROTEINS; Author-Supplied Keyword: 15n relaxation; Author-Supplied Keyword: calmodulin; Author-Supplied Keyword: domain motion; Author-Supplied Keyword: nmr; Author-Supplied Keyword: protein dynamics; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107301705
T1  - Attention-deficit disorder. Born to be hyperactive?
AU  - Zametkin AJ
AU  - Zametkin, A J
Y1  - 1995/06/21/
N1  - Accession Number: 107301705. Language: English. Entry Date: 19981201. Revision Date: 20161112. Publication Type: journal article; case study; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Attention Deficit Hyperactivity Disorder -- Familial and Genetic
KW  - Attention Deficit Hyperactivity Disorder -- Drug Therapy
KW  - Attention Deficit Hyperactivity Disorder -- Physiopathology
KW  - Attention Deficit Hyperactivity Disorder -- Diagnosis
KW  - Diagnosis, Differential
KW  - Attention Deficit Hyperactivity Disorder -- Therapy
KW  - Child
KW  - Adult
KW  - Aged
KW  - Male
SP  - 1871
EP  - 1874
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 273
IS  - 23
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1384, USA
AD  - Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD
U2  - PMID: 7776505.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854684
T1  - Telomeres, telomerase, and immortality.
AU  - Rhyu MS
Y1  - 1995/06/21/
N1  - Accession Number: 105854684. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Chromosomes
KW  - Neoplasms
KW  - Transferases -- Metabolism
KW  - Animals
KW  - Apoptosis -- Physiology
KW  - Biochemical Phenomena -- Physiology
KW  - Cell Physiology -- Physiology
KW  - Documentation
KW  - Nucleotides
KW  - Transferases -- Antagonists and Inhibitors
KW  - Transferases
SP  - 884
EP  - 894
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 12
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 7666477.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854685
T1  - Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo.
AU  - Kato S
AU  - Bowman ED
AU  - Harrington AM
AU  - Blomeke B
AU  - Shields PG
Y1  - 1995/06/21/
N1  - Accession Number: 105854685. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Hydrocarbons -- Metabolism
KW  - Lung -- Metabolism
KW  - Nucleotides -- Metabolism
KW  - Nucleotides
KW  - Polymorphism, Genetic
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Cotinine -- Blood
KW  - Documentation
KW  - Female
KW  - Hemeproteins
KW  - Lung
KW  - Male
KW  - Middle Age
KW  - Smoking -- Blood
KW  - Smoking
KW  - Transferases
SP  - 902
EP  - 907
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 12
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Etiology, National Cancer Institute, Bethesda, Md 20892, USA.
U2  - PMID: 7666479.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854687
T1  - Hypersensitivity reactions to chemotherapy agents in patients receiving chemoimmunotherapy with high-dose interleukin 2.
AU  - Heywood GR
AU  - Rosenberg SA
AU  - Weber JS
Y1  - 1995/06/21/
N1  - Accession Number: 105854687. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antineoplastic Agents, Combined -- Adverse Effects
KW  - Drug Hypersensitivity -- Etiology
KW  - Interleukin 2 -- Adverse Effects
KW  - Melanoma -- Drug Therapy
KW  - Proteins -- Adverse Effects
KW  - Adult
KW  - Blood Pressure -- Drug Effects
KW  - Drug Hypersensitivity -- Physiopathology
KW  - Edema -- Chemically Induced
KW  - Female
KW  - Interleukin 2 -- Administration and Dosage
KW  - Male
KW  - Melanoma
KW  - Middle Age
KW  - Proteins -- Administration and Dosage
KW  - Skin -- Drug Effects
SP  - 915
EP  - 922
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 12
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Treatment, National Cancer Institute, Bethesda, Md., USA.
U2  - PMID: 7666481.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854688
T1  - Risk of pancreatic cancer following diabetes mellitus: a nationwide cohort study in Sweden.
AU  - Chow WH
AU  - Gridley G
AU  - Nyrén O
AU  - Linet MS
AU  - Ekbom A
AU  - Fraumeni JF Jr
AU  - Adami HO
Y1  - 1995/06/21/
N1  - Accession Number: 105854688. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Diabetes Mellitus -- Complications
KW  - Pancreatic Neoplasms -- Epidemiology
KW  - Pancreatic Neoplasms -- Etiology
KW  - Adult
KW  - Aged
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Prospective Studies
KW  - Relative Risk
KW  - Sweden
KW  - Human
SP  - 930
EP  - 931
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 12
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Etiology, National Cancer Institute, Bethesda, Md, USA.
U2  - PMID: 7666483.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854688&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 
TY  - JOUR
ID  - 107314209
T1  - A surprising advance in the treatment of viral leukemia.
AU  - Gallo RC
Y1  - 1995/06/29/
N1  - Accession Number: 107314209. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Leukemia, Lymphocytic -- Drug Therapy
KW  - Leukemia, Lymphocytic -- Etiology
KW  - Oncogenic Viruses
SP  - 1783
EP  - 1785
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 332
IS  - 26
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Cancer Institute, Bethesda, MD 20892-4255
U2  - PMID: 7760898.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107370390
T1  - Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy.
AU  - Hibbeln JR
AU  - Salem N Jr.
Y1  - 1995/07//
N1  - Accession Number: 107370390. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Depression -- Prevention and Control
KW  - Dietary Fats -- Adverse Effects
KW  - Fatty Acids, Unsaturated
KW  - Cholesterol
KW  - Depression -- Epidemiology
KW  - Coronary Disease
KW  - Alcoholism
KW  - Multiple Sclerosis
KW  - Affective Disorders
KW  - Stress, Psychological
KW  - Nervous System Physiology
SP  - 1
EP  - 9
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 62
IS  - 1
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Laboratory of Membrane Biophysics and Biochemistry, DICBR, National Institute of Alcohol Abuse and Alcoholism, 12501 Washington Avenue, Rockville, MD 20852
U2  - PMID: 7598049.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107370390&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Weed, Douglas L.
T1  - Epidemiology, the Humanities, and Public Health.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/07//
VL  - 85
IS  - 7
M3  - Article
SP  - 914
EP  - 918
PB  - American Public Health Association
SN  - 00900036
AB  - Epidemiologists may benefit from the disciplines of history, philosophy of science, ethics, literature, and art. Within these disciplines lie answers to the questions of who we are, what is right, how to think, and when to act. Studying and participating in the humanities may also help epidemiologists focus their professional concerns on the humanity their methods serve. A parallel phenomenon in the clinical sciences-medical humanities-provides support for the approach (and some lessons). [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDEMIOLOGISTS
KW  - SOCIAL sciences
KW  - PHILOSOPHY of science -- Study & teaching
KW  - HUMANITIES -- Study & teaching
KW  - LITERATURE -- Study & teaching
KW  - MEDICINE -- Study & teaching
KW  - HISTORY -- Study & teaching
N1  - Accession Number: 9508091224; Weed, Douglas L. 1; Affiliation:  1: Preventive Oncology Branch, National Cancer Institute, Bethesda, Md; Source Info: Jul1995, Vol. 85 Issue 7, p914; Subject Term: EPIDEMIOLOGISTS; Subject Term: SOCIAL sciences; Subject Term: PHILOSOPHY of science -- Study & teaching; Subject Term: HUMANITIES -- Study & teaching; Subject Term: LITERATURE -- Study & teaching; Subject Term: MEDICINE -- Study & teaching; Subject Term: HISTORY -- Study & teaching; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scheidt, Peter C.
AU  - Harel, Yossi
AU  - Trumble, Ann C.
AU  - Jones, Diane H.
AU  - Overpeck, Mary D.
AU  - Bijur, Polly E.
T1  - The Epidemiology of Nonfatal Injuries among US Children and Youth.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/07//
VL  - 85
IS  - 7
M3  - Article
SP  - 932
EP  - 938
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. National data are not routinely available regarding the incidence of and associated risk factors for nonfatal injuries in children and youth. The Child Health Supplement to the 1988 National Health Interview Survey provided an opportunity to determine accurate national estimates of childhood injury morbidity by demographic factors, location, external cause, nature of injury, and other factors. Methods. The closest adult for 17 110 sampled children was asked whether the child had had an injury, accident, or poisoning during the preceding 12 months and about the cause, location, and consequences of the event. An analysis for potential underreporting from 12 months of recall provided adjustments of annual rates to those for a 1-month recall period. Results. On the basis of 2772 reported injuries, the national estimated annual rate for children 0 to 17 years of age was 27 per 100 children after adjustment to 1-month recall. Boys experienced significantly higher rates than girls (risk ratio [RR] = 1.52, 95% confidence interval [CI] = 1.37, 1.68), and adolescents experienced the highest overall rate (38 per 100 children) and proportion of serious injuries. Conclusions. Approximately one fourth of US children experience a medically attended injury each year, but the risks vary considerably depending on the characteristics of subgroups and the injury cause. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILDREN -- Wounds & injuries
KW  - YOUTH
KW  - WOUNDS & injuries
KW  - SURVEYS
KW  - CHILDREN'S accidents
KW  - DISEASES
N1  - Accession Number: 9508091228; Scheidt, Peter C. 1 Harel, Yossi 2 Trumble, Ann C. 1 Jones, Diane H. 3 Overpeck, Mary D. 1 Bijur, Polly E. 4; Affiliation:  1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md  2: Department of Sociology, Bar Ilan University, Ramat Gan, Israel  3: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga  4: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY; Source Info: Jul1995, Vol. 85 Issue 7, p932; Subject Term: CHILDREN -- Wounds & injuries; Subject Term: YOUTH; Subject Term: WOUNDS & injuries; Subject Term: SURVEYS; Subject Term: CHILDREN'S accidents; Subject Term: DISEASES; Number of Pages: 7p; Illustrations: 2 Charts, 14 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sorlie, Paul D.
AU  - Backlund, Eric
AU  - Keller, Jacob B.
T1  - US Mortality by Economic, Demographic, and Social Characteristics: The National Longitudinal Mortality Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/07//
VL  - 85
IS  - 7
M3  - Article
SP  - 949
EP  - 956
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. A large US sample was used to estimate the effects of race, employment status, income, education, occupation, marital status, and household size on mortality. Methods. Approximately 530 000 persons 25 years of age or more were identified from selected Current Population Surveys between 1979 and 1985. These individuals were followed for mortality through use of the National Death Index for the years 1979 through 1989. Results. Higher mortality was found in Blacks than in whites less than 65 years of age; in persons not in the labor force, with lower incomes, with less education, and in service and other lower level occupations; and in persons not married and living alone. With occasional exceptions, in specific sex and age groups, these relationships were reduced but remained strong and statistically significant when each variable was adjusted for all of the other characteristics. The relationships were generally weaker in individuals 65 years of age or more. Conclusions. Employment status, income, education, occupation, race, and marital status have substantial net associations with mortality. This study identified segments of the population in need of public health attention and demonstrated the importance of including these variables in morbidity and mortality studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MORTALITY
KW  - RESEARCH
KW  - MANPOWER
KW  - INCOME
KW  - RACE
KW  - MARITAL status
KW  - HOUSEHOLDS
KW  - DEMOGRAPHY
KW  - UNITED States
N1  - Accession Number: 9508091231; Sorlie, Paul D. 1 Backlund, Eric 2 Keller, Jacob B. 1; Affiliation:  1: Epidemiology and Biometry Program, National Heart, Lung and Blood Institute, Bethesda, Md  2: Bureau of the Census, Suitland, Md; Source Info: Jul1995, Vol. 85 Issue 7, p949; Subject Term: MORTALITY; Subject Term: RESEARCH; Subject Term: MANPOWER; Subject Term: INCOME; Subject Term: RACE; Subject Term: MARITAL status; Subject Term: HOUSEHOLDS; Subject Term: DEMOGRAPHY; Subject Term: UNITED States; NAICS/Industry Codes: 814110 Private Households; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mendes De Leon, Carlos F.
AU  - Fillenbaum, Gerda G.
AU  - Williams, Christianna S.
AU  - Brock, Dwight B.
AU  - Beckett, Laurel A.
AU  - Berkman, Lisa F.
T1  - Functional Disability among Elderly Blacks and Whites in Two Diverse Areas: The New Haven and North Carolina EPESE.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/07//
VL  - 85
IS  - 7
M3  - Article
SP  - 994
EP  - 998
PB  - American Public Health Association
SN  - 00900036
AB  - This study examines the prevalence of functional disability (limitation in at least one basic activity of daily living) among elderly Black and White community residents in the New Haven (n = 2812) and North Carolina (n = 4162) sites of the Established Populations for Epidemiologic Studies of the Elderly (EPESE). In New Haven, elderly Blacks, particularly women below age 75, had a higher prevalence of disability compared with Whites, which was partially attributable to a higher prevalence of chronic conditions. In North Carolina, Blacks had only a slightly higher risk of being disabled than Whites, and this was fully accounted for by differences in socioeconomic status. Black-White differences in the prevalence of functional disability reveal geographic variation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OLDER people with disabilities
KW  - OLDER African Americans
KW  - EPIDEMIOLOGY -- Research
KW  - SOCIAL status
KW  - NEW Haven (Conn.)
KW  - CONNECTICUT
KW  - NORTH Carolina
N1  - Accession Number: 9508091241; Mendes De Leon, Carlos F. 1 Fillenbaum, Gerda G. 2 Williams, Christianna S. 1 Brock, Dwight B. 3 Beckett, Laurel A. 4 Berkman, Lisa F. 1; Affiliation:  1: Department of Epidemiology and Public Health, Yale University, New Haven, Conn  2: Center for Study on Aging and Human Development, Duke University, Durham, NC  3: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Md  4: Center for Research on Health and Aging, Rush Presbyterian St. Luke's Medical Center, Chicago, Ill; Source Info: Jul1995, Vol. 85 Issue 7, p994; Subject Term: OLDER people with disabilities; Subject Term: OLDER African Americans; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: SOCIAL status; Subject Term: NEW Haven (Conn.); Subject Term: CONNECTICUT; Subject Term: NORTH Carolina; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107373702
T1  - Etiology of brain tumors in adults.
AU  - Inskip PD
AU  - Linet MS
AU  - Heineman EF
Y1  - 1995/07//7/ 1/1995
N1  - Accession Number: 107373702. Language: English. Entry Date: 19960601. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 7910703. 
KW  - Brain Neoplasms -- In Adulthood
KW  - Brain Neoplasms -- Classification
KW  - Age Factors
KW  - Carcinogens
KW  - Brain Neoplasms -- Etiology -- In Adulthood
KW  - Radiation, Ionizing -- Adverse Effects
KW  - Electromagnetic Fields -- Adverse Effects
KW  - Occupational Exposure
KW  - Diet
KW  - Infection
KW  - Brain Neoplasms -- Familial and Genetic -- In Adulthood
KW  - Brain Neoplasms -- Physiopathology -- In Adulthood
KW  - Adult
SP  - 382
EP  - 414
JO  - Epidemiologic Reviews
JF  - Epidemiologic Reviews
JA  - EPIDEMIOL REV
VL  - 17
IS  - 2
PB  - Oxford University Press / USA
SN  - 0193-936X
AD  - Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 408, 6130 Executive Blvd., Rockville, MD 20852
U2  - PMID: 8654518.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107416513
T1  - Cardiovascular technology.
AU  - Furst E
Y1  - 1995/07//1995 Jul
N1  - Accession Number: 107416513. Language: English. Entry Date: 19950801. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8703516. 
KW  - Dobutamine -- Therapeutic Use
KW  - Echocardiography, Transesophageal
KW  - Coronary Disease -- Ultrasonography
KW  - Myocardial Ischemia -- Ultrasonography
KW  - Cardiac Patients
KW  - Echocardiography, Transesophageal -- Adverse Effects
KW  - Cardiovascular Nursing
SP  - 24
EP  - 35
JO  - Journal of Cardiovascular Nursing
JF  - Journal of Cardiovascular Nursing
JA  - J CARDIOVASC NURS
VL  - 9
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Transesophageal dobutamine stress echocardiography uses ultrasonic imaging of the myocardium from the esophagus and stomach during the infusion of incremental doses of dobutamine. Given the semi-invasive nature of the procedure, the nurse who assists the physician plays an essential role in the successful completion of the test. This method is useful for the evaluation of patients with coronary artery disease and for investigations based on ultrasound imaging of the myocardium. Its expanding applications emphasize the relevance of a nursing collaboration and thereby create an opportunity to increase nurses' participation in echocardiography laboratories.
SN  - 0889-4655
AD  - National Institutes of Health, Bethesda, Maryland
U2  - PMID: 7666066.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rosenthal, Dean S.
AU  - Shima, Thomas B.
AU  - Celli, Giulia
AU  - de Luca, Luigi M.
AU  - Smulson, Mark E.
T1  - Engineered Human Skin Model Using Poly(ADP-Ribose) Polymerase Antisense Expression Shows a Reduced Response to DNA Damage.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/07//
VL  - 105
IS  - 1
M3  - Article
SP  - 38
EP  - 43
SN  - 0022202X
AB  - Poly(ADP-ribose) polymerase (PADPRP) modifies nuclear proteins in response to DNA-damaging agents. The principal organ subject to exposure to many of these agents is the skin. To understand the role of PADPRP in the maintenance of the epidermis, a model system has been developed in which we have selectively lowered the levels of this enzyme by the use of induced expression of antisense RNA. Human keratinocyte lines were stably transfected with the cDNA for human PADPRP in the antisense orientation under an inducible promoter. Induction of this antisense RNA in cultured cells selectively lowers the levels of PADPRP mRNA, protein, and enzyme activity. Induction of antisense RNA also led to a reduction in the levels of PADPRP in individual cell nuclei, as well as the loss of the ability of cells to synthesize and modify proteins by poly(ADP-ribose) polymer in response to DNA damage. When keratinocyte clones containing the antisense construct or empty vector alone were grafted onto nude mice, they formed histologically normal human skin. The PADPRP antisense construct was also inducible <em>in vivo</em> by the topical application of dexamethasone to the reconstituted epidermis. In addition, poly(ADP-ribose) polymer could be induced and detected <em>in vivo</em> following the topical application of a DNA alkylating agent to the grafted transfected skin layers. Accordingly, a model system has been developed in which the levels of PADPRP can be selectively manipulated in human keratinocytes in cell culture, and potentially in reconstituted epidermis as well. This system will be a useful tool to study the role of PADPRP and DNA repair in general in essential biologic processes in the epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - DNA
KW  - EPIDERMIS
KW  - CELLS
KW  - KERATINOCYTES
KW  - CELL culture
KW  - <em>DNA repair</em>
KW  - <em>Grafting</em>
KW  - <em>MNNG</em>
KW  - <em>sulfur mustard</em>
N1  - Accession Number: 12312525; Rosenthal, Dean S. 1 Shima, Thomas B. 1 Celli, Giulia 2 de Luca, Luigi M. 2 Smulson, Mark E. 1; Affiliation:  1: Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington. D.C.  2: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul95, Vol. 105 Issue 1, p38; Subject Term: SKIN; Subject Term: DNA; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: KERATINOCYTES; Subject Term: CELL culture; Author-Supplied Keyword: <em>DNA repair</em>; Author-Supplied Keyword: <em>Grafting</em>; Author-Supplied Keyword: <em>MNNG</em>; Author-Supplied Keyword: <em>sulfur mustard</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12312525
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107419253
T1  - Improving food frequency questionnaires: a qualitative approach using cognitive interviewing.
AU  - Subar AF
AU  - Thompson FE
AU  - Smith AF
AU  - Jobe JB
AU  - Ziegler RG
AU  - Potischman N
AU  - Schatzkin A
AU  - Hartman A
AU  - Swanson C
AU  - Kruse L
AU  - Hayes RB
AU  - Lewis DR
AU  - Harlan LC
Y1  - 1995/07//
N1  - Accession Number: 107419253. Language: English. Entry Date: 19950901. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions; questionnaire/scale; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Instrument Construction
KW  - Questionnaires
KW  - Food Habits
KW  - Interviews
KW  - Audiorecording
KW  - Questionnaires -- Evaluation
KW  - Education, Continuing (Credit)
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 781
EP  - 790
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 95
IS  - 7
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - National Cancer Institute, Division of Cancer Prevention and Control, EPN 313, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892-7344
U2  - PMID: 7797809.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
T1  - Relief of Left Ventricular Outflow Tract Obstruction Following Inadvertent Left Ventricular Apical Pacing in a Patient with Hypertrophic Cardiomyopathy.
AU  - Chang, Anthony C.
AU  - Atiga, Walter L.
AU  - McAreavey, Dorothea
AU  - Fananapazir, Lameh
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
Y1  - 1995/07//
VL  - 18
IS  - 7
SP  - 1450
EP  - 1454
SN  - 01478389
N1  - Accession Number: 17562596; Author: Chang, Anthony C.: 1 Author: Atiga, Walter L.: 1 Author: McAreavey, Dorothea: 1 Author: Fananapazir, Lameh: 1 ; Author Affiliation: 1 Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20050713
N2  - Dual chamber (DDD) pacing improves symptoms and relieves left ventricular (LV) outflow obstruction in hypertrophic cardiomyopathy. The ventricular lead is usually positioned at the right ventricular apex (RVA). We report a patient in whom the ventricular lead had inadvertently penetrated the septum. resulting in DDD pacing from the LV apex. however, after 3 months, obstruction was reduced and symptoms were improved. Pacing from LV apex and RVA resulted in comparable hemodynamic improvement. This case suggests that the asynchronous wave of septal contraction, originating from the apex, irrespective of ventricular site, accounts for the reduction in LV outflow obstruction. ABSTRACT FROM AUTHOR
KW  - *HYPERTROPHIC cardiomyopathy
KW  - *CARDIOMYOPATHIES
KW  - *LEFT heart ventricle
KW  - *CARDIAC pacing
KW  - *PATIENTS
KW  - *HEMODYNAMICS
KW  - hypertrophic cardiomyopathy
KW  - pacing
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 105855694
T1  - Relief of left ventricular outflow tract obstruction following inadvertent left ventricular apical pacing in a patient with hypertrophic cardiomyopathy.
AU  - Chang AC
AU  - Atiga WL
AU  - McAreavey D
AU  - Fananapazir L
Y1  - 1995/07//
N1  - Accession Number: 105855694. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7803944. 
KW  - Cardiac Pacing, Artificial
KW  - Cardiomyopathy, Hypertrophic -- Therapy
KW  - Heart Diseases -- Complications
KW  - Adult
KW  - Electrocardiography
KW  - Heart Diseases -- Therapy
KW  - Male
SP  - 1450
EP  - 1454
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
JA  - PACING CLIN ELECTROPHYSIOL
VL  - 18
IS  - 7
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0147-8389
AD  - Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
U2  - PMID: 7567600.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Leyendecker, Birgit
AU  - Lamb, Michael E.
AU  - Schölmerich, Axel
AU  - Fracasso, Maria P.
T1  - The social worlds of 8- and 12-month-old Infants: Early experiences in two subcultural context.
JO  - Social Development
JF  - Social Development
Y1  - 1995/07//
VL  - 4
IS  - 2
M3  - Article
SP  - 194
EP  - 208
SN  - 0961205X
AB  - In this study, we explored the everyday experiences of 40 infants from families who migrated recently from Central America to the US. Another 42 infants from middle class families of Euro-American background were included to facilitate the evaluation of our methodology and findings. Detailed descriptions of the previous 24 hours were obtained by interviewing the mothers when their infants were 8 and 12 months of age. The infants' experiences and activities were very similar in both groups, and the effects of the mothers' fathers' or others' presence on ongoing activities were similar, too. The groups differed with regard to (1) the circadian distribution of activities, (2) opportunities for interactions with various people, and (3) the differences between weekdays and weekends. Overall, the social worlds of the Central American children were characterized by the simultaneous presence of several people and thus by multiple social partners. The social worlds of the Euro-American children were characterized by more opportunities for dyadic interactions and by exposure to fewer partners. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEWBORN infants -- Psychology
KW  - TRANSNATIONALISM
KW  - MIDDLE class families
KW  - CHILD psychology
KW  - SOCIAL values
KW  - CENTRAL America
KW  - UNITED States
KW  - child rearing practices
KW  - Cross-cultural comparison
KW  - infant experience
KW  - social values
N1  - Accession Number: 11634969; Leyendecker, Birgit 1 Lamb, Michael E. 1 Schölmerich, Axel 1 Fracasso, Maria P. 1; Affiliation:  1: National Institute of Child Health and Human Development; Source Info: Jul95, Vol. 4 Issue 2, p194; Subject Term: NEWBORN infants -- Psychology; Subject Term: TRANSNATIONALISM; Subject Term: MIDDLE class families; Subject Term: CHILD psychology; Subject Term: SOCIAL values; Subject Term: CENTRAL America; Subject Term: UNITED States; Author-Supplied Keyword: child rearing practices; Author-Supplied Keyword: Cross-cultural comparison; Author-Supplied Keyword: infant experience; Author-Supplied Keyword: social values; Number of Pages: 15p; Document Type: Article
L3  - 10.1111/1467-9507.ep11634969
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1996-09356-001
AN  - 1996-09356-001
AU  - Montoya, Ivan D.
AU  - Umbricht, Annie
AU  - Preston, Kenzie L.
T1  - Buprenorphine for human immunovirus-positive opiate-dependent patients.
JF  - Biological Psychiatry
JO  - Biological Psychiatry
JA  - Biol Psychiatry
Y1  - 1995/07//
VL  - 38
IS  - 2
SP  - 135
EP  - 136
CY  - Netherlands
PB  - Elsevier Science
SN  - 0006-3223
N1  - Accession Number: 1996-09356-001. PMID: 7578651 Partial author list: First Author & Affiliation: Montoya, Ivan D.; NIH/National Institute on Drug Abuse, Intramural Research Program, Clinical Trials Section, Baltimore, MD, US. Release Date: 19960301. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Detoxification; Drug Dependency; HIV; Narcotic Antagonists; Opiates. Minor Descriptor: Buprenorphine. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 2. Issue Publication Date: Jul, 1995. 
AB  - Reported the safety and efficacy of buprenorphine for an 8-day inpatient detoxification of 2 HIV-positive opiate dependent men. The Ss experienced no serious side effects and reported reduction in the Addiction Research Center Inventory opiate withdrawal scale and Clinical Investigation Narcotic Assessment scores. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - buprenorphine
KW  - detoxification
KW  - HIV posotive males with opiate dependency
KW  - letter
KW  - 1995
KW  - Detoxification
KW  - Drug Dependency
KW  - HIV
KW  - Narcotic Antagonists
KW  - Opiates
KW  - Buprenorphine
KW  - 1995
DO  - 10.1016/0006-3223(95)00071-N
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UR  - ORCID: 0000-0003-0603-2479
UR  - 
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37310-023
AN  - 2015-37310-023
AU  - Tombran-Tink, Joyce
AU  - Shivaram, Sunil M.
AU  - Chader, Gerald J.
AU  - Johnson, Lincoln V.
AU  - Bok, Dean
T1  - Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/07//
VL  - 15
IS  - 7
SP  - 4992
EP  - 5003
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Tombran-Tink, Joyce, National Eye Institute, National Institutes of Health, Building 6, Room 311, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37310-023. PMID: 7623128 Partial author list: First Author & Affiliation: Tombran-Tink, Joyce; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Johnson, Lincoln V. Major Descriptor: Epithelial Cells; Gene Expression; Pigments; Retina; Neurotrophic Factor. Minor Descriptor: Monkeys; Neurons; Photoreceptors. Classification: Genetics (2510). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Jul, 1995. Publication History: Accepted Date: Feb 16, 1995; Revised Date: Feb 9, 1995; First Submitted Date: Sep 14, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - Retinal pigment epithelial (RPE) cells form a functional complex with photoreceptor neurons of the retina, interacting through the interphotoreceptor matrix (IPM). We now provide evidence that the gene for pigment epithelium-derived factor (PEDF), a protein possessing neurotrophic and neuronal-survival activities, is highly expressed by both fetal and young adult RPE cells. PEDF mRNA is present in RPE cells of the human eye at 17 weeks of gestation, demonstrating its potential for action in vivo during early retinal development. The PEDF protein is secreted in vivo where it constitutes a part of the fetal and adult IPM surrounding photoreceptor outer segments. A polyclonal PEDF antibody recognizes at least four isoforms of secreted human and bovine PEDF by two dimensional gel analysis, and detects a similar 50 kDa protein in the IPM of several other vertebrate species. Within soluble extracts of RPE cells, however, where little, if any, of the 50 kDa species can be detected, an immunoreactive 36 kDa protein is observed by Western blot analysis. By immunofluorescence, PEDF is localized intracellularly in association with the nucleus, presumptive secretory granules, and cytoskeletal elements of cultured RPE cells with PEDF and actin antibodies colocalizing to the same cytoskeletal structures. During initial stages of attachment, PEDF and actin also concentrate at the tips of pseudopods extended by the cultured RPE cells. However, with successive passages, synthesis, and secretion of the PEDF protein as well as transcription of its mRNA decrease and are lost by about 10 passages. In parallel, cultured RPE cells lose their proliferative potential and change from an epithelial-like morphology in early passages to a more fibroblast-like appearance by about the 10th passage. PEDF is thus apparently present intracellularly and extracellularly in both fetal and early adult periods where it could be involved in cellular differentiation and survival and with its loss, in the onset of senescence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - serpin
KW  - neurotrophic factor
KW  - pigment epithelium-derived factor (PEDF)
KW  - aging
KW  - cytoskeietal structure
KW  - neural retina
KW  - pigment epithelium
KW  - interphotoreceptor matrix
KW  - actin
KW  - tissue culture
KW  - 1995
KW  - Epithelial Cells
KW  - Gene Expression
KW  - Pigments
KW  - Retina
KW  - Neurotrophic Factor
KW  - Monkeys
KW  - Neurons
KW  - Photoreceptors
KW  - 1995
U1  - Sponsor: National Eye Institute, US. Grant: EY04741. Recipients: Johnson, Lincoln V.
U1  - Sponsor: National Eye Institute, US. Grant: NE1 EY00444, NE1 EY00331. Recipients: Bok, Dean
U1  - Sponsor: National RP Foundation Fighting Blindness. Recipients: Bok, Dean
U1  - Sponsor: Sponsor name not included. Other Details: Dolly Green Endowment. Recipients: Bok, Dean
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105854701
T1  - Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine.
AU  - Tsang KY
AU  - Zaremba S
AU  - Nieroda CA
AU  - Zhu MZ
AU  - Hamilton JM
AU  - Schlom J
Y1  - 1995/07/05/
N1  - Accession Number: 105854701. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antigens -- Immunology
KW  - Antigens, Tumor -- Immunology
KW  - Histocompatibility Antigens -- Immunology
KW  - T Lymphocytes -- Immunology
KW  - Viral Vaccines -- Immunology
KW  - Viruses -- Immunology
KW  - Amino Acids
KW  - Carcinoma -- Immunology
KW  - Colorectal Neoplasms -- Immunology
KW  - Documentation
KW  - Flow Cytometry
SP  - 982
EP  - 990
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 13
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 7629885.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854701&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854704
T1  - Effect of human T-lymphotropic virus type I infection on non-Hodgkin's lymphoma incidence.
AU  - Cleghorn FR
AU  - Manns A
AU  - Falk R
AU  - Hartge P
AU  - Hanchard B
AU  - Jack N
AU  - Williams E
AU  - Jaffe E
AU  - White F
AU  - Bartholomew C
Y1  - 1995/07/05/
N1  - Accession Number: 105854704. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Lymphoma, Non-Hodgkin's -- Epidemiology
KW  - Lymphoma, Non-Hodgkin's
KW  - RNA Virus Infections -- Complications
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Child
KW  - Child, Preschool
KW  - Demography
KW  - Female
KW  - Incidence
KW  - Infant
KW  - Jamaica
KW  - Male
KW  - Middle Age
KW  - Phenotype
KW  - Trinidad and Tobago
SP  - 1009
EP  - 1014
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 13
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
U2  - PMID: 7629870.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Enk, Alexander H.
AU  - Katz, Stephen I.
T1  - Contact Sensitivity as a Model for T-Cell Activation in Skin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/07/15/Jul95 Supplement
VL  - 105
M3  - Article
SP  - 80S
EP  - 83S
SN  - 0022202X
AB  - Contact sensitivity has served as a useful model for the primary activation of T cells in skin and skin-associated lymphoid tissue. We have been interested in the early signals necessary for the induction of an allergen-specific T-cell response, as well as the factors controlling the intensity and extent of such an immune reaction. Because cytokines qualified as possible candidate molecules involved in directing primary immune responses in skin, we studied the early changes in the cytokine pattern of the epidermis. Apart from defining a cytokine pattern specifically induced only after application of allergen, we also identified Langerhans-cell-derived interleukin (IL)-1β as the first cytokine to be induced by allergen, within 15 min of hapten application. Further experiments demonstrated that IL-1β also subserved an essential function for the induction of contact sensitivity reactions, as injection of IL-1β into the ears of mice mimicked the application of contact allergen on the morphologic, phenotypic, and functional level. In addition, injection of anti-IL-1β  monoclonal antibody before application of allergen completely prevented sensitization. We also identified the production of IL-10 by murine keratinocytes. IL-10 may serve as a counterregulatory molecule in contact hypersensitivity, as it functionally suppressed Langerhans cell accessory cell function by preventing the expression of certain costimulatory molecules on the surface of these antigen-presenting cells. Indeed IL-10 converts those cells from potent inducers of primary immune responses to tolerizing antigen-presenting cells. The tolerizing function of IL-10 has also been described <em>in vivo</em>. Intradermal injection of IL-10 before application of the allergen induces hapten-specific tolerance <em>in vivo</em>. In aggregate, our data indicate that epidermally derived cytokines are intimately involved in the modulation of immune reactions in the skin, in some cases enhancing sensitization and in others inducing specific immunologic tolerance and anergy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONTACT dermatitis
KW  - T cells
KW  - LYMPHOID tissue
KW  - SKIN diseases
KW  - IMMUNE response
KW  - CYTOKINES
KW  - <em>cytokines</em>
KW  - <em>T-cell anergy.</em>
N1  - Accession Number: 12316112; Enk, Alexander H. 1 Katz, Stephen I. 2; Affiliation:  1: Clinical Research Unit, Dermatology Department, Johannes Gutenberg Universität Mainz, Mainz, Germany.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul95 Supplement, Vol. 105, p80S; Subject Term: CONTACT dermatitis; Subject Term: T cells; Subject Term: LYMPHOID tissue; Subject Term: SKIN diseases; Subject Term: IMMUNE response; Subject Term: CYTOKINES; Author-Supplied Keyword: <em>cytokines</em>; Author-Supplied Keyword: <em>T-cell anergy.</em>; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12316112
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Blauvelt, Andrew
AU  - Katz, Stephen I.
T1  - The Skin as Target, Vector, and Effector Organ in Human Immunodeficiency Virus Disease.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/07/15/Jul95 Supplement
VL  - 105
M3  - Article
SP  - 122S
EP  - 126S
SN  - 0022202X
AB  - Langerhans cells are CD4+ antigen-presenting cells in the dendritic cell family that can initiate primary and secondary immune responses after emigration from skin and mucosa. Because of these properties, Langerhans cells have been proposed as potential targets for human immunodeficiency virus (HIV) infection and as potential vectors for the transmission of primary HIV infection to T cells after mucosal exposure. In support of this theory, previous investigative studies have demonstrated that Langerhans cells are targets for HIV infection both <em>in vivo</em> and <em>in vitro</em> and that HIV-pulsed Langerhans cells, as well as blood dendritic cells, induce a productive infection in co-cultured T cells <em>in vitro</em>. In addition, Langerhans cell dysfunction has been proposed as contributing to the pathogenesis of some of the cutaneous manifestations observed in HIV+ individuals. In a recent study, we detected Langerhans cell dysfunction in patients with acquired immune deficiency syndrome, but not in earlier stages of HIV disease. Here we review previous and current investigative studies on HIV and the skin, with an emphasis on Langerhans cells, and discuss possible future investigations in this field. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - ANTIGEN presenting cells
KW  - DENDRITIC cells
KW  - IMMUNE response
KW  - HIV (Viruses)
KW  - EPIDERMIS
KW  - IMMUNOLOGY
KW  - <em>AIDS.</em>
KW  - <em>antigen-presenting cells</em>
KW  - <em>dendritic cells</em>
KW  - <em>Langerhans cells</em>
N1  - Accession Number: 12316662; Blauvelt, Andrew 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul95 Supplement, Vol. 105, p122S; Subject Term: LANGERHANS cells; Subject Term: ANTIGEN presenting cells; Subject Term: DENDRITIC cells; Subject Term: IMMUNE response; Subject Term: HIV (Viruses); Subject Term: EPIDERMIS; Subject Term: IMMUNOLOGY; Author-Supplied Keyword: <em>AIDS.</em>; Author-Supplied Keyword: <em>antigen-presenting cells</em>; Author-Supplied Keyword: <em>dendritic cells</em>; Author-Supplied Keyword: <em>Langerhans cells</em>; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12316662
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Houn, Florence
AU  - Bober, Mary A.
AU  - Huerta, Elmer E.
AU  - Hursting, Stephen D.
AU  - Lemon, Stephen
AU  - Weed, Douglas L.
T1  - The Association Between Alcohol and Breast Cancer: Popular Press Coverage of Research.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/08//Aug1995 Part 1 of 2
VL  - 85
IS  - 8
M3  - Article
SP  - 1082
EP  - 1086
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study was undertaken to examine popular press reports of the association between alcohol and breast cancer. Methods. Articles from scientific journals and stories from newspapers and magazines published from January 1, 1985, to July 1, 1992, were retrieved from six on-line databases. Lay press stories were analyzed to determine which medical articles were publicized and what information was reported. Results. Fifty-eight scientific articles on the relationship of alcohol and breast cancer were found, and 64 newspaper and 23 magazine stories were retrieved. The press cited 11 studies, 19% of those published during the study period. Three studies were featured in 77% of popular press stories. No scientific review articles were reported. Behavioral recommendations were given to the public in 63% of stories. Conclusions. The vast majority of scientific studies on alcohol and breast cancer were ignored in press reports. We encourage researchers and the popular press to give the public a broader understanding of public health issues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOL -- Physiological effect
KW  - BREAST cancer
KW  - PUBLIC health
KW  - PRESS
KW  - SCIENCE publishing
N1  - Accession Number: 9508231567; Houn, Florence 1 Bober, Mary A. 1 Huerta, Elmer E. 1 Hursting, Stephen D. 1 Lemon, Stephen 1 Weed, Douglas L. 1; Affiliation:  1: National Cancer Institute, Bethesda, Md; Source Info: Aug1995 Part 1 of 2, Vol. 85 Issue 8, p1082; Subject Term: ALCOHOL -- Physiological effect; Subject Term: BREAST cancer; Subject Term: PUBLIC health; Subject Term: PRESS; Subject Term: SCIENCE publishing; NAICS/Industry Codes: 519110 News Syndicates; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 511130 Book Publishers; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lipman, Paula Darby
AU  - Caplan, Leslie J.
AU  - Schooler, Carmi
AU  - Lee, Jason S.
T1  - Inside and Outside the Mind: The Effects of Age, Organization, and Access to External Sources on Retrieval of Life Events.
JO  - Applied Cognitive Psychology
JF  - Applied Cognitive Psychology
Y1  - 1995/08//
VL  - 9
IS  - 4
M3  - Article
SP  - 289
EP  - 306
PB  - John Wiley & Sons, Inc.
SN  - 08884080
AB  - Older and middle-aged adults recorded autobiographical events on one of two forms of a Personal History Calendar, organized either by year-of occurrence or by life event category. In Experiment 1, calendars were completed in three stages. In Stage 1, subjects completed the calendar from memory (half were told to expect Stage 2). In Stage 2, each subject reviewed Stage 1 responses with his/her spouse. In Stage 3, subjects could consult external sources. The Event Calendar yielded the most complete Stave 1 recall only for the older group. The Year Calendar generally yielded the greatest number of events, but only when members of a couple did not expect Stage 2. In Experiment 2, subjects completed the calendars in one stage, during which they had access to external sources. The Year Calendar elicited more events than the Event Calendar, but only for older subjects. The results are discussed in terms of retrieval processes in autobiographical memory, and implications for survey-based research. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Applied Cognitive Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOBIOGRAPHICAL memory
KW  - MEDICAL history taking
KW  - CALENDARS (Publications)
KW  - MEMORY testing
KW  - RECALL (Information retrieval)
KW  - MEDICAL informatics
KW  - COGNITIVE psychology
N1  - Accession Number: 12013995; Lipman, Paula Darby 1 Caplan, Leslie J. 1 Schooler, Carmi 1 Lee, Jason S. 2; Affiliation:  1: National Institute of Mental Health, USA  2: General Accounting Office, USA; Source Info: Aug95, Vol. 9 Issue 4, p289; Subject Term: AUTOBIOGRAPHICAL memory; Subject Term: MEDICAL history taking; Subject Term: CALENDARS (Publications); Subject Term: MEMORY testing; Subject Term: RECALL (Information retrieval); Subject Term: MEDICAL informatics; Subject Term: COGNITIVE psychology; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107421893
T1  - Programmed instruction: biotherapy. The immune system and cancer... this is the first in a series of five self-learning modules that will review biotherapy... part 1.
AU  - Tomaszewski JG
AU  - DeLaPena L
AU  - Gantz SB
AU  - Beranto DL
AU  - Woolery-Antill M
AU  - DiLorenzo K
AU  - Molenda J
AU  - Folts S
Y1  - 1995/08//1995 Aug
N1  - Accession Number: 107421893. Language: English. Entry Date: 19951001. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Biological Therapy
KW  - Neoplasms -- Therapy
KW  - Immune System -- Physiology
KW  - Cell Physiology
KW  - Programmed Instruction
KW  - Stem Cells
KW  - Cytokines
KW  - T Lymphocytes
KW  - Leukocytes
KW  - Macrophages
KW  - Education, Continuing (Credit)
SP  - 313
EP  - 331
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 18
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0162-220X
AD  - National Institutes of Health, Clinical Center, Cancer/Human Genome Nursing Service, Bethesda, Maryland
U2  - PMID: 7664259.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Cheung, S. C.
AU  - Takeda, S.
AU  - Notkins, A. L.
T1  - Both VH and VL chains of polyreactive IgM antibody are required for polyreactivity: expression of Fab in Escherichia coli.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1995/08//
VL  - 101
IS  - 2
M3  - Article
SP  - 383
EP  - 386
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Monoclonal polyreactive antibodies can bind to many structurally dissimilar self and non-self antigens. Neither the precise antigen-binding site on the polyreactive antibody molecule nor the molecular basis of polyreactivity has been elucidated. The present study was initiated to see whether antibody genes encoding the Fab fragment of a human monoclonal polyreactive IgM antibody (MoAb 67) could be efficiently expressed in Escherichia coli and whether the bacterially expressed Fab fragments possessed biological activity. cDNA encoding the variable domains of the heavy and light chains of MoAb 67 were cloned, amplified by polymerase chain reaction (PCR) and expressed in E. coli. Neither the recombinant heavy nor light chain showed antigen-binding activity. In contrast, the recombinant Fab 67 fragment showed the same antigen-binding reactivity profile as the native IgM antibody. It is concluded that the antigen-binding activity of polyreactive antibodies resides in the Fab fragment, and that both the heavy and light chains are required for activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - ESCHERICHIA coli
KW  - ANTIGENS
KW  - ENTEROBACTERIACEAE
KW  - POLYMERASE chain reaction
KW  - POLYMERIZATION
KW  - antibody genes
KW  - antigen-binding
KW  - Escherichia coli
KW  - expression system
KW  - Fab fragment
KW  - polyreactive antibodies
N1  - Accession Number: 16195667; Cheung, S. C. 1 Takeda, S. 1 Notkins, A. L. 1; Affiliation:  1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.; Source Info: Aug1995, Vol. 101 Issue 2, p383; Subject Term: IMMUNOGLOBULINS; Subject Term: ESCHERICHIA coli; Subject Term: ANTIGENS; Subject Term: ENTEROBACTERIACEAE; Subject Term: POLYMERASE chain reaction; Subject Term: POLYMERIZATION; Author-Supplied Keyword: antibody genes; Author-Supplied Keyword: antigen-binding; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: expression system; Author-Supplied Keyword: Fab fragment; Author-Supplied Keyword: polyreactive antibodies; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Martin, Susan E.
T1  - "A CROSS-BURNING IS NOT JUST ARSON": POLICE SOCIAL CONSTRUCTION OF HATE CRIMES IN BALTIMORE COUNTY.
JO  - Criminology
JF  - Criminology
Y1  - 1995/08//
VL  - 33
IS  - 3
M3  - Article
SP  - 303
EP  - 326
SN  - 00111384
AB  - Growing public concern over racial and ethnic conflict and a perceived increase in hate crimes during the 1980s have led to legislation expanding the scope of the law and the severity of punishment for such offenses and to police-initiated efforts to focus attention on hate  crimes. Although a number of critiques have examined the legislative approach, little attention has been devoted to the police response. This article examines the rationale for a police initiative in addressing hate crimes; the characteristics of incidents labeled as such in one  jurisdiction, Baltimore County, Maryland; and some of the problems in defining, identifying, and verifying bias motivation. Because about 40% of the offenses initially considered by the Baltimore County Police Department to be motivated by racial, religious, or ethnic (RRE) prejudice subsequently are not verified as RRE motivated, a closer examination of all such cases permits insight into the social construction of "bias motivation" and related issues raised by a police hate-crime  program. These include determining what forms of bias are eligible for special responses; identifying bias motivation; weighing the victim's perception of the event; determining the line between criminal and  noncriminal incidents; and adopting consistent standards for verifying ambiguous events. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Criminology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ETHNIC relations
KW  - HATE crimes
KW  - CRIME
KW  - PUNISHMENT
KW  - CRIMINAL justice administration
KW  - POLICE
KW  - PREJUDICES
N1  - Accession Number: 9508236281; Martin, Susan E. 1; Affiliation:  1: Health scientist administrator, Prevention Research Branch, National Institute on Alcohol Abuse and Alcoholism; Source Info: Aug95, Vol. 33 Issue 3, p303; Subject Term: ETHNIC relations; Subject Term: HATE crimes; Subject Term: CRIME; Subject Term: PUNISHMENT; Subject Term: CRIMINAL justice administration; Subject Term: POLICE; Subject Term: PREJUDICES; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 912130 Provincial police services; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 911230 Federal police services; Number of Pages: 24p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mendz, George L.
AU  - Barden, Julian A.
AU  - Martenson, Russell E.
T1  - Conformation of a tetradecapeptide epitope of myelin basic protein.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/08//8/1/95
VL  - 231
IS  - 3
M3  - Article
SP  - 659
EP  - 666
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The peptide AcAla-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-Tyr, which comprises the first 14 residues of the acetylated N-terminus of myelin basic protein, is an epitopic site for two monoclonal antibodies to the human protein. The conformations of the tetradecapeptide in aqueous solutions were investigated employing high-resolution 1H- and 13C-NMR spectroscopy. Two-dimensional techniques were used to assign the spectra observed from both nuclei. Nuclear-Overhauser-effect data, amide proton temperature coefficients, 13C spin-lattice relaxation times, distance geometry calculations and dynamic simulated annealing provided evidence that the solution conformations of the tetradecapeptide included a nascent (α-helix in the N-terminal segment, and a loop extending from Ser7 to Ser12 that bring His10 and Tyr14 into close proximity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENIC determinants
KW  - MYELIN basic protein
KW  - NUCLEAR magnetic resonance
KW  - PROTEINS -- Analysis
KW  - PROTEINS -- Research
KW  - CHEMICAL kinetics
KW  - BIOCHEMISTRY
KW  - conformation
KW  - epitope
KW  - myelin basic protein
KW  - nmr
N1  - Accession Number: 12761075; Mendz, George L. 1 Barden, Julian A. 2 Martenson, Russell E. 3; Affiliation:  1: School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia  2: Department of Anatomy and Histology, University of Sydney, Australia  3: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda MD, USA; Source Info: 8/1/95, Vol. 231 Issue 3, p659; Subject Term: ANTIGENIC determinants; Subject Term: MYELIN basic protein; Subject Term: NUCLEAR magnetic resonance; Subject Term: PROTEINS -- Analysis; Subject Term: PROTEINS -- Research; Subject Term: CHEMICAL kinetics; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: conformation; Author-Supplied Keyword: epitope; Author-Supplied Keyword: myelin basic protein; Author-Supplied Keyword: nmr; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pohla-Gubo, G.
AU  - Lazarova, Z.
AU  - Giudice, G. J.
AU  - Liebert, M.
AU  - Grassegger, A.
AU  - Hintner, H.
AU  - Yancey, Kim. B.
T1  - Diminished expression of the extracellular doman of bullous pemphigoid antigen 2 (BPAG2) in the epidermal basement membrane of patients with generalized atrophic benign epidermolysis bullosa.
JO  - Experimental Dermatology
JF  - Experimental Dermatology
Y1  - 1995/08//8/1/95  part 1
VL  - 4
M3  - Article
SP  - 199
EP  - 206
SN  - 09066705
AB  - Generalized atrophic benign epidermolysis bullosa (GABEB) is a nonlethal form of junctional epidermolysis bullosa characterized by generalized skin and mucosal blisters that heal with atrophy; other features include alopecia, nail dystrophy, large melanocytic nevi, and autosomal recessive inheritance. The specific aim of this study was to identify an abnormality in epidermal basement membrane adhesion molecules in well characterized GABEB patients that would explain why these subjects' epidermis separates from their epidermal basement membrane. Cryostat sections of nonlesional skin from 8 GABEB patients in 5 different families as well as skin from normal volunteers (controls) were studied by indirect immunofluorescence microscopy using rabbit antiserum directed against a BPAG1 fusion protein or monoclonal antibodies directed against the extracellular domain of BPAG2 (HD18 and 233), epiligrin (P1E1), laminin 5 (GB3), types IV and VII collagen, or integrin subunits α[SUB1], α[SUB2], β[SUB1], α[SUB6], or β[SUB4]. In these studies, monoclonal antibodies HD18 and 233 showed no reactivity and diminished reactivity, respectively, to the epidermal BM of all GABEF patients. Interestingly, in one patient, the absent or diminished reactivitics molmonoclonal anti-BPAG2 antibodies were limited to well demarcated portions of an otherwise intact epidermal basement membrane. Moreover, BPAG1, epiligrin, laminin 5, types IV and VII collagen, and all integrin subunits under study were expressed in the same manner in both GABEB and normal human skin. These findings identify an abnormality in the extracellular domain of BPAG2 in the skin of GABEB patients. BPAG2 (type XVII collagen) is a transmembrane, hemidesmo- some-associated molecule whose extracellular domain resides at the exact level where blisters develop in the skin of patients with GABEB. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL adhesion
KW  - CELL interaction (Biology)
KW  - HEMIDESMOSOMES
KW  - EPITHELIAL cells
KW  - EPIDERMOLYSIS bullosa
KW  - BIOLOGICAL control systems
KW  - cell adhesion - hemidesmosomes - junctional epidermolysis bullosa
N1  - Accession Number: 11698731; Pohla-Gubo, G. 1 Lazarova, Z. 2 Giudice, G. J. 3 Liebert, M. 4 Grassegger, A. 5 Hintner, H. 1 Yancey, Kim. B. 2; Affiliation:  1: Department of Dermatology, Salzburg, Austria  2: Dermatology Branch, National Institutes of Health, Bethesda, MD, USA  3: Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA  4: Department of Urology, MD Anderson Cancer Center, Houston, TX, USA  5: Department of Dermatology, lnnsbruck, Austria; Source Info: 8/1/95  part 1, Vol. 4, p199; Subject Term: CELL adhesion; Subject Term: CELL interaction (Biology); Subject Term: HEMIDESMOSOMES; Subject Term: EPITHELIAL cells; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: BIOLOGICAL control systems; Author-Supplied Keyword: cell adhesion - hemidesmosomes - junctional epidermolysis bullosa; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1600-0625.ep11698731
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Barksdal, S. K.
AU  - Stern, J. B.
AU  - Haupt, H. M.
AU  - Multhaupt, H.
T1  - Proliferative activity in metastatic malignant melanoma: comparison of pre-treatment and post-treatment metastases.
JO  - Journal of Cutaneous Pathology
JF  - Journal of Cutaneous Pathology
Y1  - 1995/08//
VL  - 22
IS  - 4
M3  - Article
SP  - 354
EP  - 358
SN  - 03036987
AB  - In this study, the proliferative activity of malignant melanoma metastases was assessed before and after isolated limb perfusion chemotherapy by quantitating AgNORs, mitoses and PCNA activity. No significant difference, in either AgNOR count, mitotic activity or PCNA index was observed. We conclude that AgNOR count, mitotic activity and PCNA index were not significantly effected by isolated limb perfusion chemotherapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - METASTASIS
KW  - MELANOMA
KW  - CANCER
KW  - DRUG therapy
KW  - MITOSIS
KW  - RESEARCH
N1  - Accession Number: 11842339; Barksdal, S. K. 1 Stern, J. B. 1 Haupt, H. M. 2 Multhaupt, H. 2; Affiliation:  1: Laboratory of Pathology, National Institutes of Health, Bethesda.  2: Department of Pathology, Pennsylvania Hospital, Philadelphia, U.S.A.; Source Info: Aug95, Vol. 22 Issue 4, p354; Subject Term: METASTASIS; Subject Term: MELANOMA; Subject Term: CANCER; Subject Term: DRUG therapy; Subject Term: MITOSIS; Subject Term: RESEARCH; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1600-0560.ep11842339
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scandurro, Aline B.
AU  - Wang, Qizhi
AU  - Goodman, Linda
AU  - Ledbetter, Stephen
AU  - Dooley, Thomas P.
AU  - Yuspa, Stuart H.
AU  - Lichti, Ulrike
T1  - Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/08//
VL  - 105
IS  - 2
M3  - Article
SP  - 177
EP  - 183
SN  - 0022202X
AB  - An <em>in vivo</em> nude mouse graft model and an <em>in vitro</em> collagen matrix culture system were used to study interactions of immature hair follicle buds from newborn mice with clonally derived AdE1A-12S-immortalized rat whisker dermal papilla cell lines. Of the 19 available dermal papilla cell lines, four consistently supported good hair follicle development and hair growth in grafts. Seven cell lines were clearly negative in this assay, and the remaining eight cell lines yielded poor to moderate hair growth. As a correlate to <em>in vivo</em> extracellular matrix remodeling accompanying hair follicle development, type IV collagenase activity in the medium from cocultures of dermal papilla cells and hair follicle buds was analyzed by gelatin zymography. Hair follicle buds cultured alone secrete primarily the 92-kDa type IV procollagenase. Cocultivation of hair follicle buds with eight of the dermal papilla cell lines resulted in activation of this proenzyme and activation of the 72-kDa and 92-kDa type IV procollagenases produced by the dermal papilla cells. Seven of these eight dermal papilla cell lines support hair growth in the graft system. In the absence of dermal papilla cells, several growth factors induced activation of the 92-kDa procollagenase secreted by hair follicle buds cultured in serum-free medium: epidermal growth factor, transforming growth factor alpha, acidic fibroblast growth factor, and keratinocyte growth factor. The current working hypothesis is that a) hair follicle epithelial cells interact with dermal papilla cells in coculture by mutual induction of growth factors and cytokines that stimulate the release and activation of matrix remodeling proteases; and b) the ability of dermal papilla cells to interact with hair follicle epithelial cells in this way may be crucial for controlled dermal matrix remodeling during HF development. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR follicles
KW  - CELL lines
KW  - COLLAGEN
KW  - EXTRACELLULAR matrix proteins
KW  - COLLAGENASES
KW  - RATS
KW  - <em>acidic fibroblast growth factor</em>
KW  - <em>basic fibroblast growth factor</em>
KW  - <em>keratinocyte growth factor</em>
KW  - <em>transforming growth factor</em>
N1  - Accession Number: 12317089; Scandurro, Aline B. 1 Wang, Qizhi 1 Goodman, Linda 2 Ledbetter, Stephen 2 Dooley, Thomas P. 2 Yuspa, Stuart H. 1 Lichti, Ulrike 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Hairgrowth Research, The Upjohn Company, Kalamazoo, Michigan, U.S.A.; Source Info: Aug95, Vol. 105 Issue 2, p177; Subject Term: HAIR follicles; Subject Term: CELL lines; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: COLLAGENASES; Subject Term: RATS; Author-Supplied Keyword: <em>acidic fibroblast growth factor</em>; Author-Supplied Keyword: <em>basic fibroblast growth factor</em>; Author-Supplied Keyword: <em>keratinocyte growth factor</em>; Author-Supplied Keyword: <em>transforming growth factor</em>; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12317089
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costa Jr., Paul T.
AU  - McCrae, Robert R.
T1  - Primary Traits of Eysenck's P-E-N System: Three-and Five-Factor Solutions.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1995/08//
VL  - 69
IS  - 2
M3  - Article
SP  - 308
EP  - 317
SN  - 00223514
AB  - The Eysenck Personality Profiler (EPP), a set of 21 scales measuring primary traits hypothesized to be definers of Neuroticism, Extraversion, and Psychoticism factors, was administered to 229 adults together with the Eysenck Personality Questionnaire--Revised (H. J. Eysenck & S. B. G. Eysenck, 1991) and the Revised NEO Personality Inventory (NEO-PI-R; P. T. Costa & R. R. McCrae, 1992b). Correlations of EPP scales with NEO-PI-R facet scales provided preliminary evidence supporting the convergent and discriminant validity of the EPP scales. However, varimax and targeted validimax factor analyses suggested that some EPP scales were misclassified and that EPP scales could better be understood in terms of the 5-factor model than the intended 3-factor model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - EXTRAVERSION
KW  - PERSONALITY tests
KW  - FACTOR analysis
N1  - Accession Number: 9509084314; Costa Jr., Paul T. 1 McCrae, Robert R. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, National Institutes of Health; Source Info: Aug95, Vol. 69 Issue 2, p308; Subject Term: PERSONALITY; Subject Term: EXTRAVERSION; Subject Term: PERSONALITY tests; Subject Term: FACTOR analysis; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107392888
T1  - Occult caffeine as a source of sleep problems in an older population.
AU  - Brown SL
AU  - Salive ME
AU  - Pahor M
AU  - Foley DJ
AU  - Corti MC
AU  - Langlois JA
AU  - Wallace RB
AU  - Harris TB
Y1  - 1995/08//8/ 1/1995
N1  - Accession Number: 107392888. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). NLM UID: 7503062. 
KW  - Caffeine -- Adverse Effects
KW  - Sleep Disorders -- Chemically Induced -- In Old Age
KW  - Sleep Disorders -- Epidemiology
KW  - Rural Health
KW  - Drugs -- Adverse Effects
KW  - Iowa
KW  - Psychological Tests
KW  - Center for Epidemiological Studies Depression Scale
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Questionnaires
KW  - Interviews
KW  - Self Report
KW  - Data Analysis Software
KW  - Chi Square Test
KW  - T-Tests
KW  - P-Value
KW  - Confounding Variable
KW  - Multiple Logistic Regression
KW  - Prospective Studies
KW  - Cross Sectional Studies
KW  - Aged
KW  - Human
SP  - 860
EP  - 864
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - Epidemiology, Demography, Biometry Program, National Institute on Aging, Bethesda, Maryland
U2  - PMID: 7636092.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - WACHOLDER, SHOLOM
AU  - HARTGE, PATRICIA
AU  - LUBIN, JAY H.
AU  - DOSEMECI, MUSTAFA
T1  - Non-differential misclassification and bias towards the null: a clarification.
JO  - Occupational & Environmental Medicine
JF  - Occupational & Environmental Medicine
Y1  - 1995/08//
VL  - 52
IS  - 8
M3  - Article
SP  - 257
EP  - 258
SN  - 13510711
N1  - Accession Number: 89978582; WACHOLDER, SHOLOM 1; HARTGE, PATRICIA 1; LUBIN, JAY H. 1; DOSEMECI, MUSTAFA 1; Affiliations: 1: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA; Issue Info: Aug1995, Vol. 52 Issue 8, p257; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107356081
T1  - Pulmonary disease in AIDS: implications for respiratory care practitioners.
AU  - Medin DL
AU  - Ognibene FP
Y1  - 1995/08//1995 Aug
N1  - Accession Number: 107356081. Language: English. Entry Date: 19960101. Revision Date: 20150819. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7510357. 
KW  - Acquired Immunodeficiency Syndrome -- Complications
KW  - Lung Diseases
KW  - Lung Diseases -- Diagnosis
KW  - Pneumonia, Pneumocystis
KW  - Mycobacterium Infections
KW  - Lung Diseases, Parasitic
KW  - Lung Diseases, Fungal
KW  - Lung Neoplasms
KW  - Lung Diseases -- In Infancy and Childhood
KW  - Lung Diseases -- Radiography
KW  - Sputum -- Analysis
KW  - Bronchoscopy
KW  - Respiratory Function Tests
KW  - HIV-Infected Patients
KW  - Cross Infection
KW  - Cytomegalovirus Infections
KW  - Pentamidine
KW  - Ribavirin
KW  - Tuberculosis, Pulmonary
KW  - Ethics, Medical
KW  - Respiratory Therapists
KW  - Occupational Exposure
KW  - Child
KW  - Lung Diseases -- Therapy
SP  - 832
EP  - 854
JO  - Respiratory Care
JF  - Respiratory Care
JA  - RESPIR CARE
VL  - 40
IS  - 8
CY  - Irving, Texas
PB  - Daedalus Enterprises, Inc.
SN  - 0020-1324
AD  - Critical Care Medicine Dept, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 10144743.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-37426-036
AN  - 2015-37426-036
AU  - Wood, Katherine A.
AU  - Youle, Richard J.
T1  - The role of free radicals and p53 in neuron apoptosis in vivo.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/08//
VL  - 15
IS  - 8
SP  - 5851
EP  - 5857
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wood, Katherine A., Biochemistry Section, Surgical Neurology Branch, National Institutes of Health, Building 10, Room 5D37, 10 Centre Drive, Bethesda, MD, US, 20892-1414
N1  - Accession Number: 2015-37426-036. PMID: 7643225 Partial author list: First Author & Affiliation: Wood, Katherine A.; Biochemistry Section, Surgical Neurology Branch, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Apoptosis; Methanol; Neural Development; Radiation; Transcription Factors. Minor Descriptor: Mice. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 7. Issue Publication Date: Aug, 1995. Publication History: Accepted Date: Apr 19, 1995; Revised Date: Mar 9, 1995; First Submitted Date: Sep 20, 1994. Copyright Statement: Society for Neuroscience. 1995. 
AB  - Apoptosis is a mechanism of cell death operative in the normal development and regulation of vertebrate tissues and organ cellularity. During the postnatal development of the mouse cerebellum, extensive granule neuron apoptosis occurs that may regulate the final granule cell to Purkinje cell stoichiometry observed in the adult. Cerebellar granule cells are highly sensitive to genotoxic agents such as gamma-irradiation and methylazoxymethanol during the first 2 weeks of postnatal development. We demonstrate that ionizing radiation induces extensive cerebellar granule cell death via apoptosis in vivo. In p53 null mice, however, the cerebellar granule cells do not undergo apoptosis in response to gamma-irradiation. In mice heterozygous for the p53 allele, the granule cells apoptosis is delayed, indicating an intermediate response. The developmental apoptosis of cerebellar granule cells, however, occurs similarly in wild-type and p53 null mice. Therefore, neurons undergo p53-dependent and p53-independent apoptosis, depending upon the initiating stimulus that triggers DNA fragmentation. In contrast to x-ray damage, the extensive death of cerebellar granule cells induced by methylazoxymethanol was found to be independent of the DNA fragmentation characteristic of apoptosis, and was also independent of expression of p53. Ablation of neuron progenitor cells with genotoxic agents may occur by p53-dependent apoptosis or by p53-independent mechanisms not associated with DNA fragmentation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cerebellum
KW  - x-irradiation
KW  - methylazoxymethanol
KW  - apoptosis
KW  - p53
KW  - free radicals
KW  - 1995
KW  - Apoptosis
KW  - Methanol
KW  - Neural Development
KW  - Radiation
KW  - Transcription Factors
KW  - Mice
KW  - 1995
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Metcalfe, Dean D.
AU  - Mekori, Joseph A.
AU  - Rottem, Menachem
T1  - Mast cell ontogeny and apoptosis.
JO  - Experimental Dermatology
JF  - Experimental Dermatology
Y1  - 1995/08/02/8/2/95 Part 2
VL  - 4
M3  - Article
SP  - 227
EP  - 230
SN  - 09066705
AB  - The regulation of tissue mast cell number depends both on the rate of production of mast cell precursors from bone marrow and the length of survival of mature mast cells within tissues. Mast cells develop from bone marrow under the influence of both interleukin-3 (IL-3) and the e-kit ligand, also known as stem cell factor (SCF). In humans, the mast cell precursor is CD34+, Fc[SUBE]RI-. Mast cell precursors with time become less responsive to IL-3 and more responsive to SCF Mast cell proliferation directed by SCF is enhanced by other cytokines including both IL-4 and IL-10. Once mast cell precursors target to tissues, their survival may largely be dependent upon the local production of SCF. Withdrawal of IL-3 or SCF results in mast cell apoptosis; SCF rescues mast cells following IL-3 withdrawal. TGF-beta prevents this SCF rescue. Engagement of extracellular matrix by integrin receptors may also effect mast cell numbers. Thus, in the final analysis, mast cell numbers, while relatively constant in the normal state, may be up-regulated by altering the rate of their production centrally or length of survival in the periphery. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - TISSUES
KW  - BONE marrow cells
KW  - MATRICES
KW  - CELL proliferation
KW  - CYTOKINES
KW  - apoptosis
KW  - hematopoiesis
KW  - IL-3
KW  - mast cells
KW  - stem cell factor
N1  - Accession Number: 11698959; Metcalfe, Dean D. 1 Mekori, Joseph A. 2 Rottem, Menachem 3; Affiliation:  1: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.  2: The Allergy-Clinical Immunology Unit, Department of Medicine, Meir General Hospital and the Sackler School of Medicine, Tel-Aviv University, Israel.  3: The Department of Pediatrics, Afula Central Emek Hospital, Afula, Israel.; Source Info: 8/2/95 Part 2, Vol. 4, p227; Subject Term: CELLS; Subject Term: TISSUES; Subject Term: BONE marrow cells; Subject Term: MATRICES; Subject Term: CELL proliferation; Subject Term: CYTOKINES; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: hematopoiesis; Author-Supplied Keyword: IL-3; Author-Supplied Keyword: mast cells; Author-Supplied Keyword: stem cell factor; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1600-0625.ep11698959
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107375432
T1  - Breast cancer among radiologic technologists.
AU  - Boice JD Jr.
AU  - Mandel JS
AU  - Doody MM
AU  - Boice, J D Jr
AU  - Mandel, J S
AU  - Doody, M M
Y1  - 1995/08/02/
N1  - Accession Number: 107375432. Language: English. Entry Date: 19960701. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Swift M, Daly M, Bernstein L, Love S M. Breast cancer among radiologic technologists. (JAMA) 8/7/96; 276 (5): 369-370. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: N01-CP9-5614/CP/NCI NIH HHS/United States. NLM UID: 7501160. 
KW  - Neoplasms, Radiation-Induced -- Etiology
KW  - Breast Neoplasms -- Etiology
KW  - Technology, Radiologic
KW  - Occupational Diseases -- Etiology
KW  - Data Analysis, Statistical
KW  - Case Control Studies
KW  - Funding Source
KW  - Risk Factors
KW  - Radiation, Ionizing
KW  - Occupational Exposure
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Human
SP  - 394
EP  - 401
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 274
IS  - 5
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To evaluate the risk of breast cancer among women occupationally exposed to ionizing radiation.Design: Case-control study.Participants: A health survey of 105,385 women radiologic technologists certified by the American Registry of Radiologic Technologists since 1926. Among 79,016 respondents, 600 breast cancer cases were identified. Each of 528 eligible subjects with breast cancer was matched to five control subjects based on age, year of certification, and follow-up time.Main Outcome Measures: Relative risk (RR) estimated as the relative odds ratio for breast cancer over categories of years worked as a radiologic technologist and according to personal and occupational exposure characteristics.Results: Study subjects had been certified for a mean of 29 years; 63.8% of cases and 62.6% of controls worked as radiologic technologists for 10 years or more. Significant increased risks for breast cancer were associated with early age at menarche (for < 11 years of age: RR = 1.79; 95% confidence interval [CI], 1.09 to 2.94), nulliparity (RR = 1.36; 95% CI, 1.04 to 1.78), first-degree relative with history of breast cancer (RR = 2.07; 95% CI, 1.56 to 2.74), prior breast biopsy (RR = 1.53; 95% CI, 1.17 to 2.00), alcohol consumption (for > 14 alcoholic drinks per week: RR = 2.12; 95% CI, 1.06 to 4.27), thyroid cancer (RR = 5.36; 95% CI, 1.64 to 17.5), hyperthyroidism (RR = 1.66; 95% CI, 1.02 to 2.71), and residence in the northeastern United States (RR = 1.66; 95% CI, 1.19 to 2.30). Jobs involving radiotherapy, radioisotopes, or fluoroscopic equipment, however, were not linked to breast cancer risk, nor were personal exposures to fluoroscopy or multifilm procedures. Use of birth control pills, postmenopausal estrogens, or permanent hair dyes also were not risk factors. Based on dosimetry records for 35% of study subjects, cumulative exposures appeared low. Among women who worked more than 20 years, the RR for breast cancer was 1.13 (95% CI, 0.79 to 1.64).Conclusions: More than 50% of the reported breast cancers could be explained by established risk factors. Employment as a radiologic technologist, however, was not found to increase the risk of breast cancer. The contribution of prolonged exposure to relatively low doses of ionizing radiation to breast cancer risk was too small to be detectable at this time.
SN  - 0098-7484
AD  - Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA
AD  - Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Md
U2  - PMID: 7616635.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107375432&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107375437
T1  - Studies of cancer and radiation dose among atomic bomb survivors. The example of breast cancer.
AU  - Land CE
AU  - Land, C E
Y1  - 1995/08/02/
N1  - Accession Number: 107375437. Language: English. Entry Date: 19960701. Revision Date: 20161112. Publication Type: journal article; tables/charts. Commentary: Howe G R. Radiation-related health risks. Future directions for research. (JAMA) 8/2/95; 274 (5): 427-428. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Breast Neoplasms -- Etiology -- Japan
KW  - Neoplasms, Radiation-Induced -- Etiology -- Japan
KW  - Nuclear Warfare
KW  - Risk Factors
KW  - Japan
KW  - Age Factors
KW  - Dose-Response Relationship, Radiation
KW  - Environmental Exposure
KW  - Radiation, Ionizing -- Adverse Effects -- Japan
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Female
SP  - 402
EP  - 407
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 274
IS  - 5
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - A comprehensive program of medical follow-up of survivors of the atomic bombings of Hiroshima and Nagasaki, Japan, by the Radiation Effects Research Foundation (RERF) has produced quantitative estimates of cancer risk from exposure to ionizing radiation. For breast cancer in women, in particular, the strength of the radiation dose response and the generally low level of population risk in the absence of radiation exposure have led to a clear description of excess risk and its variation by age at exposure and over time following exposure. Comparisons of RERF data with data from medically irradiated populations have yielded additional information on the influence of population and underlying breast cancer rates on radiation-related risk. Epidemiological investigations of breast cancer cases and matched controls among atomic bomb survivors have clarified the role of reproductive history as a modifier of the carcinogenic effects of radiation exposure. Finally, a pattern of radiation-related risk by attained age among the survivors exposed during childhood or adolescence suggests the possible existence of a radiation-susceptible subgroup. The hypothetical existence of such a group is lent plausibility by the results of recent family studies suggesting that heritable mutations in certain genes are associated with familial aggregations of breast cancer. The recent isolation and cloning of one such gene, BRCA1, makes it likely that the hypothesis can be tested using molecular assays of archival and other tissue obtained from atomic bomb survivor cases and controls.
SN  - 0098-7484
AD  - Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7362, USA
AD  - Radiation Epidemiology Branch, National Cancer Institute, EPN 408, 6130 Executive Blvd, MS 7362, Bethesda, MD 20892-7362
U2  - PMID: 7616636.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107375437&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854753
T1  - What does it mean to be a cancer gene carrier? Problems in establishing causality from the molecular genetics of cancer.
AU  - Schatzkin A
AU  - Goldstein A
AU  - Freedman LS
Y1  - 1995/08/02/
N1  - Accession Number: 105854753. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Heterozygote
KW  - Mutation
KW  - Neoplasms
KW  - Environmental Exposure
KW  - Neoplasms -- Epidemiology
KW  - Relative Risk
KW  - Human
SP  - 1126
EP  - 1130
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 15
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Cancer Prevention Studies Branch, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 7674316.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854753&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854754
T1  - The use of gene tests to detect hereditary predisposition to cancer: economic considerations.
AU  - Brown ML
AU  - Kessler LG
Y1  - 1995/08/02/
N1  - Accession Number: 105854754. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Colorectal Neoplasms -- Economics
KW  - Colorectal Neoplasms
KW  - Genetic Screening -- Economics
KW  - Genetic Techniques -- Methods
KW  - Mutation
KW  - Adult
KW  - Cost Benefit Analysis
KW  - Female
KW  - Genetic Screening -- Methods
KW  - Genotype
KW  - Male
KW  - Middle Age
KW  - Population
KW  - Predictive Value of Tests
KW  - Prevalence
KW  - Quality of Life
KW  - Human
SP  - 1131
EP  - 1136
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 15
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Applied Research Branch Surveillance Program, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 7674317.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854754&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854756
T1  - Potential impact of genetic testing on cancer prevention trials, using breast cancer as an example.
AU  - Baker SG
AU  - Freedman LS
Y1  - 1995/08/02/
N1  - Accession Number: 105854756. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Prevention and Control
KW  - Breast Neoplasms
KW  - Clinical Trials -- Economics
KW  - Genetic Screening
KW  - Genetic Techniques
KW  - Mutation
KW  - Adult
KW  - Age Factors
KW  - Female
KW  - Middle Age
KW  - Relative Risk
KW  - Study Design
KW  - Time Factors
KW  - Human
SP  - 1137
EP  - 1144
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 15
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Biometry Branch, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 7674318.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854756&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105852572
T1  - Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium.
AU  - Doppman JL
AU  - Chang R
AU  - Fraker DL
AU  - Norton JA
AU  - Alexander HR
AU  - Miller DL
AU  - Collier E
AU  - Skarulis MC
AU  - Gorden P
Y1  - 1995/08/15/
N1  - Accession Number: 105852572. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Acids, Acyclic -- Diagnostic Use
KW  - Insulinoma -- Diagnosis
KW  - Pancreatic Neoplasms -- Diagnosis
KW  - Acids, Acyclic -- Administration and Dosage
KW  - Adult
KW  - Aged
KW  - Female
KW  - Hepatic Veins
KW  - Injections, Intraarterial
KW  - Insulin -- Blood
KW  - Insulin
KW  - Insulinoma
KW  - Male
KW  - Middle Age
KW  - Pancreatic Neoplasms
KW  - Sensitivity and Specificity
KW  - Human
SP  - 269
EP  - 273
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 123
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
AB  - OBJECTIVE: To determine the sensitivity of calcium injected into pancreatic arteries in localizing insulin-secreting tumors to regions of the pancreas. DESIGN AND PATIENTS: To stimulate the release of insulin, 25 patients with surgically proven insulinomas (average diameter, 15 mm) had calcium gluconate (0.025 mEq Ca++/kg body weight) injected before surgery into the arteries supplying the pancreatic head (gastroduodenal and superior mesenteric arteries) and the body and tail (splenic artery) of the pancreas. SETTING: Tertiary referral hospital. MEASUREMENTS: Insulin levels were measured in samples taken from the right and left hepatic veins before and 30, 60, and 120 seconds after calcium injection. A twofold increase in insulin level in the sample taken from the right hepatic vein 30 or 60 seconds after injection localized the insulinoma to the segment of the pancreas supplied by the selectively injected artery. Localization done using calcium stimulation was compared with localization done using transcutaneous ultrasonography (n = 22), computed tomography (n = 23), magnetic resonance imaging (n = 21), arteriography (n = 25), and portal venous sampling (n = 9). RESULTS: Calcium stimulation localized 22 of 25 insulinomas (sensitivity, 88% [95% CI, 68% to 97%]) to the correct region of the pancreas. The sensitivities of the other imaging methods were 9% for ultrasonography (CI, 1% to 23%), 17% for computed tomography (CI, 5% to 39%), 43% for magnetic resonance imaging (CI, 22% to 66%), 36% for arteriography (CI, 18% to 57%), and 67% for portal venous sampling (CI, 30% to 93%). Calcium stimulation added only a few minutes to the time needed for pancreatic arteriography and caused no morbid conditions. CONCLUSION: Intra-arterial calcium stimulation with right hepatic vein sampling for insulin gradients is the most sensitive preoperative test for localizing insulinomas.
SN  - 0003-4819
AD  - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1182, USA.
U2  - PMID: 7611592.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105852572&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105852576
T1  - NIH conference. Airway inflammation.
AU  - Shelhamer JH
AU  - Levine SJ
AU  - Wu T
AU  - Jacoby DB
AU  - Kaliner MA
AU  - Rennard SI
Y1  - 1995/08/15/
N1  - Accession Number: 105852576. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Lung Diseases -- Physiopathology
KW  - Bronchi -- Physiopathology
KW  - Cytokines -- Physiology
KW  - Eicosanoids
KW  - Epithelium -- Physiopathology
KW  - Inflammation -- Physiopathology
KW  - Lung Diseases -- Etiology
KW  - United States
SP  - 288
EP  - 304
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 123
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
AB  - Diseases characterized by airway inflammation, excessive airway secretion, and airway obstruction affect a substantial proportion of the population. These diseases include asthma, chronic bronchitis, bronchiectasis, and cystic fibrosis. Asthma and chronic bronchitis may affect 25 million persons in the United States. Much progress has been made in the last decade toward an understanding of the mechanisms underlying chronic airway inflammation; recent work has resulted in several new concepts of the initiation and maintenance of airway inflammation. Airway production of chemokines, cytokines, and growth factors in response to irritants, infectious agents, and inflammatory mediators may play an important role in the modulation of acute and chronic airway inflammation. Lipid mediators may be produced by resident airway cells and by inflammatory cells; production of these mediators may also be altered by inflammatory cytokines. Increased airway obstruction may be related to intercurrent viral respiratory infection and to the induction of airway inflammation and airway hyperreactivity that results from such infection. Furthermore, several models exist to explain the processes by which airway inflammation is perpetuated in diseases such as asthma and chronic bronchitis. These include neurogenic inflammation, the perpetuation of the acute inflammatory response, and cycles of airway epithelial cell-mediated and inflammatory cell-mediated recruitment and activation of inflammatory cells. An understanding of these mechanisms of airway inflammation may provide the clinician with new therapeutic approaches to the treatment of these common and chronic diseases.
SN  - 0003-4819
AD  - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 7611596.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105852576&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107376405
T1  - HDL cholesterol predicts coronary heart disease mortality in older persons.
AU  - Corti M
AU  - Guralnik JM
AU  - Salive ME
AU  - Harris T
AU  - Field TS
AU  - Wallace RB
AU  - Berkman LF
AU  - Seeman TE
AU  - Glynn RJ
AU  - Hennekens CH
AU  - Havlik RJ
AU  - Corti, M C
AU  - Guralnik, J M
AU  - Salive, M E
AU  - Harris, T
AU  - Field, T S
AU  - Wallace, R B
AU  - Berkman, L F
AU  - Seeman, T E
AU  - Glynn, R J
Y1  - 1995/08/16/
N1  - Accession Number: 107376405. Language: English. Entry Date: 20000201. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: N01-AG-02107/AG/NIA NIH HHS/United States. NLM UID: 7501160. 
KW  - Lipoproteins, HDL Cholesterol -- Diagnostic Use -- In Old Age
KW  - Coronary Disease -- Mortality -- In Old Age
KW  - Data Analysis, Statistical
KW  - Sex Factors
KW  - Cardiovascular Risk Factors
KW  - Coronary Disease -- Epidemiology -- In Old Age
KW  - Funding Source
KW  - Age Factors
KW  - Prospective Studies
KW  - Interviews
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 539
EP  - 544
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 274
IS  - 7
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objectives: To examine the relationship of total cholesterol and high-density lipoprotein cholesterol (HDL-C) with coronary heart disease (CHD) mortality and with occurrence of new CHD events in persons aged 71 years and older.Design: Prospective cohort study with a median of 4.4 years of follow-up.Setting: East Boston, Mass; New Haven, Conn; and Iowa and Washington counties, Iowa.Participants: A total of 2527 women and 1377 men who completed an interview, had serum lipid determinations, and survived at least 1 year. New CHD events were evaluated in persons with no CHD history or hospitalization.Main Outcome Measures: Death due to CHD (ICD-9 codes 410 through 414 as underlying cause of death); new occurrence of CHD events (fatal CHD or hospitalization with CHD [ICD-9 codes 410 through 414]).Results: After adjustment for established CHD risk factors, the relative risk (RR) of death due to CHD for those with low HDL-C (< 0.90 mmol/L [< 35 mg/dL]) compared with the reference group (HDL-C > or = 1.55 mmol/L [> or = 60 mg/dL]) was 2.5 (95% confidence interval [CI], 1.6 to 4.0). Elevated risk was present in subgroups aged 71 through 80 years (RR, 4.1; 95% CI, 1.9 to 8.8) and over 80 years (RR, 1.8; 95% CI, 0.99 to 3.4), and in men and women. Low HDL-C predicted an increased risk of occurrence of new CHD events (RR, 1.4; 95% CI, 1.1 to 2.0), with similar but nonsignificant results in subgroups of men and women. Total cholesterol was less consistently associated with CHD mortality than HDL-C. When we compared individuals with total cholesterol of at least 6.20 mmol/L (240 mg/dL) with the reference group with total cholesterol of 4.16 to 5.19 mmol/L (161 to 199 mg/dL), a significant risk of CHD mortality was seen for women (RR 1.8; 95% CI, 1.03 to 3.0) but not for men (RR, 1.0; 95% CI, 0.5 to 2.0). In the total population, for each 1-unit increase in the total cholesterol/HDL-C ratio there was a 17% increase in the risk of CHD death that was statistically significant.Conclusions: Low HDL-C predicts CHD mortality and occurrence of new CHD events in persons older than 70 years. Elevated total cholesterol was not found to be associated with CHD mortality in older men, but may be a risk factor for CHD in older women.
SN  - 0098-7484
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging/NIH, Bethesda, MD 20892, USA
U2  - PMID: 7629981.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107376405&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105853550
T1  - Extramedullary myeloid cell tumors. An immunohistochemical study of 29 cases using routinely fixed and processed paraffin-embedded tissue sections.
AU  - Roth MJ
AU  - Medeiros LJ
AU  - Elenitoba-Johnson K
AU  - Kuchnio M
AU  - Jaffe ES
AU  - Stetler-Stevenson M
Y1  - 1995/09//1995 Sep
N1  - Accession Number: 105853550. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7607091. 
KW  - Leukemia, Myeloid -- Pathology
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Child
KW  - Child, Preschool
KW  - DNA -- Analysis
KW  - Female
KW  - Immunohistochemistry
KW  - Lymph Nodes -- Pathology
KW  - Male
KW  - Middle Age
KW  - Oncogenes
KW  - Paraffin Embedding
KW  - Tissue Fixation
SP  - 790
EP  - 798
JO  - Archives of Pathology & Laboratory Medicine
JF  - Archives of Pathology & Laboratory Medicine
JA  - ARCH PATHOL LAB MED
VL  - 119
IS  - 9
CY  - Northfield, Illinois
PB  - College of American Pathologists
SN  - 0003-9985
AD  - Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892, USA.
U2  - PMID: 7668936.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105853550&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107393893
T1  - Temporal and spatial processing in reading disabled and normal children.
AU  - Eden GF
AU  - Stein JF
AU  - Wood HM
AU  - Wood FB
Y1  - 1995/09//1995 Sep
N1  - Accession Number: 107393893. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Edinburgh Test for Handedness (Oldfield); Wechsler Intelligence Scale for Children--Revised (WISC-R); Woodcock-Johnson Psycho-Educational Battery (Woodcock and Johnson); Diagnostic Interview for Children and Adolescents (DICA) (Herjanic); Woodcock-Johnson Math Standardized Score (WJMSS); Pig Latin Test (Olson, Wise, Conners et al); Temporal and Spatial Dot Task. NLM UID: 0100725. 
KW  - Attention -- In Infancy and Childhood
KW  - Psychophysiology -- In Infancy and Childhood
KW  - Visual Perception -- In Infancy and Childhood
KW  - Perception -- In Infancy and Childhood
KW  - Memory -- In Infancy and Childhood
KW  - Dyslexia -- Physiopathology -- In Infancy and Childhood
KW  - Cerebral Cortex -- Physiopathology -- In Infancy and Childhood
KW  - Child
KW  - Dyslexia -- Diagnosis -- In Infancy and Childhood
KW  - Dyslexia -- Psychosocial Factors -- In Infancy and Childhood
KW  - Female
KW  - Male
KW  - Phonology -- In Infancy and Childhood
KW  - Psychomotor Performance -- In Infancy and Childhood
KW  - Reaction Time -- Physiology -- In Infancy and Childhood
KW  - Analysis of Variance
KW  - Correlation Coefficient
KW  - Repeated Measures
KW  - Pearson's Correlation Coefficient
KW  - Regression
KW  - Students, Elementary
KW  - Clinical Assessment Tools
KW  - Reading -- Evaluation -- In Infancy and Childhood
KW  - Control Group
KW  - Achievement Tests
KW  - Structured Interview
KW  - Human
SP  - 451
EP  - 468
JO  - Cortex: A Journal Devoted to the Study of the Nervous System & Behavior
JF  - Cortex: A Journal Devoted to the Study of the Nervous System & Behavior
JA  - CORTEX
VL  - 31
IS  - 3
PB  - Masson SPA
AB  - The ability to process temporal and spatial visual stimuli was studied to investigate the role these functions play in the reading process. Previous studies of this type have often been confounded by memory involvement, or did not take into account the evidence which suggests a visual transient deficit in some dyslexics. Normal (n = 39), reading disabled (n = 26) and backward reading children (n = 12) were compared on a visual computer game, which consisted of a temporal and an analogous spatial dot counting task. Reading disabled children performed significantly worse than normal children on the Temporal Dot Task, but were only mildly impaired on the Spatial Dot Task. Backward readers were not significantly better than the reading disabled group on either task, suggesting that poor visual temporal processing is not specific to dyslexia. In a group of 93 children, a regression model including age, verbal IQ, phonological awareness, and visual temporal processing ability, predicted 73% of the variance of reading ability. The results suggest that dyslexics perform worse in tasks that require fast, sequential processing and that this impairment may be partially responsible for their reading difficulties.
SN  - 0010-9452
AD  - Child Psychiatry Branch, NIMH, National Institutes of Health, 9000 Rockville Pike, Bethesda MD 20892
U2  - PMID: 8536475.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107393893&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107354677
T1  - European views on palliative care.
AU  - De Conno F
Y1  - 1995/09//1995 Autumn
N1  - Accession Number: 107354677. Language: English. Entry Date: 19960101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9434451. 
KW  - Palliative Care
KW  - Terminal Care
KW  - Surveys
KW  - Questionnaires
KW  - Physicians
KW  - Nurses
KW  - Survival
KW  - Europe
KW  - Descriptive Statistics
KW  - Morphine -- Administration and Dosage
SP  - 98
EP  - 101
JO  - European Journal of Palliative Care
JF  - European Journal of Palliative Care
JA  - EUR J PALLIAT CARE
VL  - 2
IS  - 3
PB  - Hayward Medical Communications
AB  - Franco De Conno and colleagues report on a survey of palliative care provision organised by the European Association of Palliative Care.
SN  - 1352-2779
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107354677&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104779427
T1  - Mental health/substance abuse treatment in managed care: the Massachusetts Medicaid experience.
AU  - Callahan, J J
AU  - Shepard, D S
AU  - Beinecke, R H
AU  - Larson, M J
AU  - Cavanaugh, D
Y1  - 1995///Fall1995
N1  - Accession Number: 104779427. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128. 
KW  - Managed Care Programs -- Economics
KW  - Medicaid -- Administration
KW  - Mental Disorders -- Economics
KW  - State Health Plans -- Economics
KW  - Substance Use Disorders -- Economics
KW  - Cost Control -- Trends
KW  - Disability Evaluation
KW  - Human
KW  - Massachusetts
KW  - Mental Disorders -- Rehabilitation
KW  - Patient Admission -- Economics
KW  - Substance Use Disorders -- Rehabilitation
KW  - United States
SP  - 173
EP  - 184
JO  - Health Affairs
JF  - Health Affairs
JA  - HEALTH AFF
VL  - 14
IS  - 3
CY  - Bethesda, Maryland
PB  - Project HOPE/HEALTH AFFAIRS
AB  - Massachusetts was the first state to introduce a statewide specialty mental health managed care plan for its Medicaid program. This study assesses the impact of this program on expenditures, access, and relative quality. Over a one-year period, expenditures were reduced by 22 percent below predicted levels without managed care, without any overall reduction in access or relative quality. Reduced lengths-of-stay, lower prices, and fewer inpatient admissions were the major factors. However, for one population segment--children and adolescents--readmission rates increased slightly, and providers for this group were less satisfied than they were before managed care was adopted. Less costly types of twenty-four-hour care were substituted for inpatient hospital care. This experience supports the usefulness of a managed care program for mental health and substance abuse services, and the applicability of such a program to high-risk populations.
SN  - 0278-2715
AD  - National Institute of Mental Health (NIMH) Training Program, Mental Health Services Research, Heller School, Brandeis University, Waltham, MA, USA.
U2  - PMID: 7498890.
DO  - 10.1377/hlthaff.14.3.173
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104779427&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Coe, J. E.
AU  - Schell, R. F.
AU  - Ross, M. J.
T1  - Immune response in the hamster: definition of a novel IgG not expressed in all hamster strains.
JO  - Immunology
JF  - Immunology
Y1  - 1995/09//
VL  - 86
IS  - 1
M3  - Article
SP  - 141
EP  - 148
PB  - Wiley-Blackwell
SN  - 00192805
AB  - A new IgG isotype is described in serum from Syrian hamsters. This 7S-IG is called IgG3 and was isolated from IgG1 and IgG2 because of its great affinity for protein A. The unique antigenic determinants of IG3 were identified with a specific rabbit antisera. IG3 is the least expressed IgG subclass in Syrian hamsters, but serum levels increase more than 10-fold after immunization or infection. Although found in all tested outbred strains. IgG3 is expressed in only some of the commercially available inbred strains of Syrian hamsters. Five inbred hamster strains were examined, and in three strains (CB, LHC and MHA) IgG3 was not detected in normal serum or in immune serum, indicating serum levels at least 100-fold less than other normal inbred/outbred hamsters. The results of breeding experiments suggests a single gene defect is responsible for this n on-expression of IgG3. Immunodeficiency was not associated with this IgG3 deficiency. Selective deficiencies of immunoglobulin classes/subclasses in experimental animals are rare. The evolution of a similar IgG3 deficiency in these three hamster strains during inbreeding suggests a novel and efficient mechanism for regulation of IgG3 synthesis in the Syrian hamster. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GOLDEN hamster
KW  - IMMUNE response
KW  - IMMUNOGLOBULIN G
KW  - IMMUNOGLOBULINS
KW  - IMMUNITY
KW  - IMMUNOLOGY
KW  - MEDICAL sciences
N1  - Accession Number: 14087792; Coe, J. E. 1 Schell, R. F. 2 Ross, M. J. 2; Affiliation:  1: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana  2: Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, Wisconsin, USA; Source Info: Sep95, Vol. 86 Issue 1, p141; Subject Term: GOLDEN hamster; Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; Subject Term: MEDICAL sciences; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Evans, V. Jeffery
T1  - The NICHD Family and Child Well-Being Research Network.
JO  - Journal of Family Issues
JF  - Journal of Family Issues
Y1  - 1995/09//
VL  - 16
IS  - 5
M3  - Article
SP  - 517
EP  - 518
SN  - 0192513X
AB  - The article features the Family and Child Well-Being Research Network, established by the United States National Institute of Child Health and Human Development (NICHD). On August 1, 1993, the National Institute of Child Health and Human Development (NICHD) established the Family and Child Well-Being Research Network and gave it the mission of mounting a systematic, multidisciplinary, research effort with respect to families and children, using secondary data analysis as its primary approach. The network has identified several topics that are important to promote an effective, working relationship among the diverse fields that form the scientific base for studies of the family. Social capital is one such topic. It is a construct that has a kinship relationship with the human capital tradition in economics, sociology, and psychology to share a theoretical foundation. An important development in family research has been the transfer of behavioral measures characteristic of small experimental or clinic studies to large-scale studies. The ability to use such measures in large studies requires a transformation of measures and their application to a wide variety of population subgroups.
KW  - FAMILY research
KW  - CHILD development
KW  - CHILDREN -- Health
KW  - FAMILIES -- United States
KW  - PUBLIC health -- United States
KW  - UNITED States
N1  - Accession Number: 9509291714; Evans, V. Jeffery 1; Affiliation:  1: National Institute of Child Health and Human Development.; Source Info: Sep95, Vol. 16 Issue 5, p517; Subject Term: FAMILY research; Subject Term: CHILD development; Subject Term: CHILDREN -- Health; Subject Term: FAMILIES -- United States; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 829
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Richard, Gabriela
AU  - Korge, Bernhard P.
AU  - Wright, Andrea R.
AU  - Mazzanti, Cinzia
AU  - Harth, Wolfgang
AU  - Annicchiarico-Petruzzelli, Margherita
AU  - Compton, John G.
AU  - Bale, Sherri J.
T1  - Hailey-Hailey Disease Maps to a 5 cM Interval on Chromosome 3q21-q24.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/09//
VL  - 105
IS  - 3
M3  - Article
SP  - 357
EP  - 360
SN  - 0022202X
AB  - Hailey-Hailey disease (HHD) is a rare autosomal dominant genodermatosis characterized by disturbed keratinocyte adhesion. The disease has recently been mapped to a 14cM region on chromosome 3q. We have further refined the location of the HHD gene by linkage analysis in six HHD families from Germany and Italy using 11 polymorphic microsatellite markers and found no evidence for genetic heterogeneity. We observed complete cosegregation between HHD and marker D3S1587, with a maximal lod score of 4.54. Detailed haplotype analyses allowed us to narrow the interval containing the HHD locus to 5cM, flanked by D3S1589 and D3S1290. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - CELL adhesion
KW  - BIOCHEMICAL markers
KW  - CHROMOSOMES
KW  - EPIDERMIS
KW  - GENES
KW  - <em>epidermis</em>
KW  - <em>Familial benign chronic pemphigus</em>
KW  - <em>genodermatosis</em>
KW  - <em>linkage</em>
N1  - Accession Number: 12320741; Richard, Gabriela 1 Korge, Bernhard P. 2 Wright, Andrea R. 1 Mazzanti, Cinzia 3 Harth, Wolfgang 4 Annicchiarico-Petruzzelli, Margherita 5 Compton, John G. 1 Bale, Sherri J. 1; Affiliation:  1: Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Klinik und Poliklinik für Dermatologie, Universität Köln, Köln, Germany.  3: Istituto Dermopatico dell'Immacolata, Rome, Italy.  4: Hautklinik Erfurt, Germany  5: Biochemistry IDI-IRCCS Laboratory, Department of Experimental Medicine, University di Roma Tor Vergata, Roma, Italy.; Source Info: Sep95, Vol. 105 Issue 3, p357; Subject Term: KERATINOCYTES; Subject Term: CELL adhesion; Subject Term: BIOCHEMICAL markers; Subject Term: CHROMOSOMES; Subject Term: EPIDERMIS; Subject Term: GENES; Author-Supplied Keyword: <em>epidermis</em>; Author-Supplied Keyword: <em>Familial benign chronic pemphigus</em>; Author-Supplied Keyword: <em>genodermatosis</em>; Author-Supplied Keyword: <em>linkage</em>; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12320741
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Linet, Martha S.
AU  - Malker, Hans S R
AU  - Chow, Wong-Ho
AU  - McLaughlin, Joseph K.
AU  - Weiner, Jan A.
AU  - Stone, B J
AU  - Ericsson, Jan L E
AU  - Fraumeni Jr., Joseph F.
T1  - Occupational Risks for Cutaneous Melanoma Among Men in Sweden.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1995/09//
VL  - 37
IS  - 9
M3  - Article
SP  - 1127
EP  - 1135
SN  - 00961736
AB  - A population-based linked-registry was used to evaluate incidence of malignant melanoma of the skin among Swedish men by industry and occupation. There were 3850 cutaneous melanoma cases identified in the 19-year follow-up of men employed in 1960. New associations were observed for men employed in the breweries and malt-processing industry and in shoe fabrication from leather and skins. Several findings supported associations previously reported in other countries, including an excess risk among workers in basic chemical production and the printing industry and among professional, technical, and white-collar workers. Risk overall was not increased among farmers, despite a significant excess of melanoma of the face, neck, and scalp. Although this linked registry analysis lacked information about specific agents, duration of employment, and occupational and recreational sun exposures, it did provide leads for new associations and confirmed previous ones. Nevertheless, because of these limitations, etiologic clues must be interpreted cautiously. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 113379788; Linet, Martha S. 1 Malker, Hans S R 1 Chow, Wong-Ho 1 McLaughlin, Joseph K. 1 Weiner, Jan A. 1 Stone, B J 1 Ericsson, Jan L E 1 Fraumeni Jr., Joseph F. 1; Affiliation:  1: 1 From the Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 2 National Board of Occupational Safety and Health, Solna, Sweden 3 National Board of Health and Welfare, Stockholm, Sweden; Source Info: Sep1995, Vol. 37 Issue 9, p1127; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107425431
T1  - PracticeCorner. Cryotherapy reduces fluorouracil-related side effects.
AU  - McAtee N
AU  - Brooks C
AU  - Dela Rosa T
Y1  - 1995/09//1995 Sep
N1  - Accession Number: 107425431. Language: English. Entry Date: 19951101. Revision Date: 20150819. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Fluorouracil -- Adverse Effects
KW  - Heat-Cold Application
SP  - 1287
EP  - 1288
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 22
IS  - 8
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
SN  - 0190-535X
AD  - National Cancer Institute, Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, MD
U2  - PMID: 8532555.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Williams, Judith K.
T1  - Afro-American Women Living with HIV Infection: Special Therapeutic Interventions for a Growing Population.
JO  - Social Work in Health Care
JF  - Social Work in Health Care
Y1  - 1995/09//
VL  - 21
IS  - 2
M3  - Article
SP  - 41
EP  - 53
SN  - 00981389
AB  - This article presents several case studies of the significance of thoughtful and effective crisis intervention designed to help African-American HIV-infected women. Women constitutes the fastest-growing group of people with AIDS in the U.S. As the total number of HIV-infected women in this country continues to grow, the number of Afro-American women living with HIV is increasing at a much higher rate than that including other women. In 1993, 36 percent of the women diagnosed with AIDS acquired the disease from heterosexual contact. In addition to the threat of or presence of HIV infection and AIDS, women of color have to battle the sexism, classism and racism of the society. Women with AIDS typically do not live as long after diagnosis as men because health care practitioners fail to recognize and diagnose it in its earliest stages and there is a resulting lack of access to treatment. Women become sicker faster and die sooner than men with AIDS. Minority women are disproportionately affected by AIDS. In 1993, 74.3 percent of the women and 75 percent of children with AIDS were African Americans or Latina. The major route of HIV infection in women is unprotected heterosexual intercourse.
KW  - HIV-positive women
KW  - AFRICAN American women
KW  - HEALTH
KW  - WOMEN -- Health
KW  - AIDS (Disease)
KW  - CRISIS intervention (Mental health services)
N1  - Accession Number: 9512094015; Williams, Judith K. 1; Affiliation:  1: Coordinator, HIV Counseling Program, National Institutes of Health, Program Supervisor, Adult HIV Social Work Team, and President, Board of Directors, Wegeners Foundation Inc.; Source Info: 1995, Vol. 21 Issue 2, p41; Subject Term: HIV-positive women; Subject Term: AFRICAN American women; Subject Term: HEALTH; Subject Term: WOMEN -- Health; Subject Term: AIDS (Disease); Subject Term: CRISIS intervention (Mental health services); NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Falck, Russel S.
AU  - Ashery, Rebecca Sager
AU  - Carlson, Robert G.
AU  - Wang, Jichuan
AU  - Siegal, Harvey A.
T1  - Injection drug users, crack smokers, and the use of human services.
JO  - Social Work Research
JF  - Social Work Research
Y1  - 1995/09//
VL  - 19
IS  - 3
M3  - Article
SP  - 164
EP  - 173
PB  - Oxford University Press / USA
SN  - 10705309
AB  - This article describes the use of human services by 245 injection drug users and 125 crack cocaine smokers living in Columbus and Dayton, Ohio. These so-called hard drug users were asked about their current involvement with six categories of human services — homeless shelters, food pantries or soup kitchens, medical services, government financial assistance, drug self-help groups, and miscellaneous services. The findings suggest that drug users are active consumers of human services; nearly 90 percent reported current involvement. The average number of services used was more than three per person. Results of multivariate analyses suggest that a host of variables influence the type and number of services used. The study found no gross patterns of discrimination. It is concluded that more information is needed about how hard drug users interact with the human services system and that expectations of what the human services system is capable of accomplishing need to be re-evaluated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Work Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abusers
KW  - DRUG addicts
KW  - CRACK cocaine
KW  - HUMAN services
KW  - COCAINE
KW  - DRUG abuse
KW  - CIGARETTE smokers
KW  - PUBLIC health
KW  - PUBLIC welfare
KW  - drug abuse
KW  - social services
KW  - utilization
N1  - Accession Number: 24230101; Falck, Russel S. 1 Ashery, Rebecca Sager 2 Carlson, Robert G. 3 Wang, Jichuan 4 Siegal, Harvey A. 5; Affiliation:  1: Project director, AIDS Prevention Research Project, Wright State University School of Medicine, 143 Biological Sciences Building, Dayton, OH 45435  2: Senior social work specialty consultant, National Institute on Drug Abuse, Rochille, MD  3: Assistant professor and director of ethnographic research, AIDS Prevention Research Project, Wright State University School of Medicine, Dayton, OH  4: Assistant professor and research director, AIDS Prevention Research Project, Wright State University School of Medicine, Dayton, OH  5: Professor and principal investigator, AIDS Prevention Research Project, Wright State University School of Medicine, Dayton, OH; Source Info: Sep95, Vol. 19 Issue 3, p164; Subject Term: DRUG abusers; Subject Term: DRUG addicts; Subject Term: CRACK cocaine; Subject Term: HUMAN services; Subject Term: COCAINE; Subject Term: DRUG abuse; Subject Term: CIGARETTE smokers; Subject Term: PUBLIC health; Subject Term: PUBLIC welfare; Author-Supplied Keyword: drug abuse; Author-Supplied Keyword: social services; Author-Supplied Keyword: utilization; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6668
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2015-37551-034
AN  - 2015-37551-034
AU  - Takahashi, Megumi
AU  - Amin, Niranjana
AU  - Grant, Philip
AU  - Pant, Harish C.
T1  - P13suc1 associates with a cdc2-like kinase in a multimeric cytoskeletal complex in squid axoplasm.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/09//
VL  - 15
IS  - 9
SP  - 6222
EP  - 6229
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Pant, Harish C., Laboratory of Neurochemistry, NINDS, NIH, Building 36, Room 4D20, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37551-034. PMID: 7666204 Partial author list: First Author & Affiliation: Takahashi, Megumi; Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Axons; Kinases; Neurofibrillary Tangles; Cytoskeleton. Minor Descriptor: Mice. Classification: Physiological Processes (2540). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: Sep, 1995. Publication History: Accepted Date: May 17, 1995; Revised Date: May 10, 1995; First Submitted Date: Apr 4, 1995. Copyright Statement: Society for Neuroscience. 2015. 
AB  - P13suc1 sepharose-conjugated beads were used to extract the kinases that phosphorylate neurofilaments in the squid giant axon. Using Western blots and in vitro kinase assays, we demonstrated the presence of an active cdc2-like kinase and its putative regulators such as cyclin E, p13, and p67 in axoplasm and a P13-axoplasm complex (P13-Ax). Protein kinase A (PKA) and casein kinase (CK) I and II were also found in the P13-Ax. Western blot analysis of the P13-Ax also demonstrated several axonal cytoskeletal components; e.g., neurofilaments (NFs; NF 60, 70, and 220), tubulin, actin, and microtubule-associated proteins. NF 220 and tubulin were phosphorylated by the kinases in the P13-Ax. To determine whether NFs bound directly to the P13 beads, or bound indirectly by association with cdc2 kinase, a washed, axon-derived neurofilament preparation that contained NFs, PKA, CKl, and tubulin, but no cdc2-like kinase, yielded no bound proteins after incubation with P13suc1. The wash supernatant from the neurofilament preparation, however, containing the cdc2-like kinase, did yield cytoskeletal components that bound to P13suc1. Moreover, a bacterial-expressed cdk5 associated with P13 beads was able to complex with selected cytoskeletal components in the washed neurofilament preparation. These data indicate that direct binding of P13 beads with a cdc2-like kinase could extract active multimeric complexes composed of axonal cytoskeletal proteins and kinases. Application of P13 chromatography may be useful in characterizing the network of functional interactions among cytoskeletal elements and protein kinases in neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - P13suc1
KW  - cdc2-like kinase
KW  - cytoskelton
KW  - tublin
KW  - axon
KW  - neurofilament
KW  - 1995
KW  - Axons
KW  - Kinases
KW  - Neurofibrillary Tangles
KW  - Cytoskeleton
KW  - Mice
KW  - 1995
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105852802
T1  - Self-report screening tests for alcohol problems in primary care.
AU  - Allen JP
AU  - Maisto SA
AU  - Connors GJ
Y1  - 1995/09/11/
N1  - Accession Number: 105852802. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Alcohol Use Disorders Identification Test (AUDIT); Michigan Alcoholism Screening Test (MAST). NLM UID: 0372440. 
KW  - Alcoholism -- Diagnosis
KW  - Alcoholism -- Prevention and Control
KW  - Health Screening -- Methods
KW  - Primary Health Care
KW  - Questionnaires
KW  - Human
SP  - 1726
EP  - 1730
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
JA  - ARCH INTERN MED
VL  - 155
IS  - 16
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0003-9926
AD  - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md, USA.
U2  - PMID: 7654105.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854776
T1  - Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride.
AU  - Trivers GE
AU  - Cawley HL
AU  - DeBenedetti VM
AU  - Hollstein M
AU  - Marion MJ
AU  - Bennett WP
AU  - Hoover ML
AU  - Prives CC
AU  - Tamburro CC
AU  - Harris CC
Y1  - 1995/09/20/
N1  - Accession Number: 105854776. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antibodies -- Drug Effects
KW  - Liver Neoplasms -- Immunology
KW  - Occupational Exposure
KW  - Oncogenes -- Immunology
KW  - Sarcoma -- Immunology
KW  - Vinyl Chloride -- Adverse Effects
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Female
KW  - Immunoblotting
KW  - Liver Neoplasms
KW  - Male
KW  - Middle Age
KW  - Precipitin Tests
KW  - Sarcoma
KW  - Time Factors
SP  - 1400
EP  - 1407
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 18
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Human Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 7658501.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854775
T1  - Loss of heterozygosity on chromosome 11q13 in microdissected human male breast carcinomas.
AU  - Sanz-Ortega J
AU  - Chuaqui R
AU  - Zhuang Z
AU  - Sobel ME
AU  - Sanz-Esponera J
AU  - Liotta LA
AU  - Emmert-Buck MR
AU  - Merino MJ
Y1  - 1995/09/20/
N1  - Accession Number: 105854775. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms, Male
KW  - Chromosomes
KW  - Mutation
KW  - Heterozygote
KW  - Genetics
KW  - Male
KW  - Reproducibility of Results
KW  - Human
SP  - 1408
EP  - 1410
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 18
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 7658502.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Ohno, Hiroshi
AU  - Stewart, Jay
AU  - Fournier, Marie-Christine
T1  - Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins.
JO  - Science
JF  - Science
Y1  - 1995/09/29/
VL  - 269
IS  - 5232
M3  - Article
SP  - 1872
EP  - 1875
SN  - 00368075
AB  - Describes the use of a yeast two-hybrid system to identify proteins that bind to tyrosine-based signals.  Interaction of the medium chains of two clathrin-associated protein complexes with tyrosine-based signals of several integral membrane proteins.
KW  - PROTEINS
KW  - TYROSINE
KW  - YEAST
N1  - Accession Number: 11016180; Ohno, Hiroshi 1 Stewart, Jay 1 Fournier, Marie-Christine 1; Affiliation:  1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health; Source Info: 9/29/1995, Vol. 269 Issue 5232, p1872; Subject Term: PROTEINS; Subject Term: TYROSINE; Subject Term: YEAST; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107357305
T1  - Parental psychological adaptation and children with HIV: a follow-up study.
AU  - Wiener L
AU  - Riekert KA
AU  - Theut S
AU  - Steinberg SM
AU  - Pizzo PA
Y1  - 1995/10//
N1  - Accession Number: 107357305. Language: English. Entry Date: 19960201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Beck Depression Inventory (BDI); Health Status Questionnaire; Parental Coping Scale; Spielberger State-Trait Anxiety Inventory (STAI); Anticipatory Grief Scale. NLM UID: 8710781. 
KW  - HIV Infections -- In Infancy and Childhood
KW  - Wilcoxon Rank Sum Test
KW  - Adaptation, Psychological
KW  - Parental Attitudes -- Evaluation
KW  - HIV-Infected Patients -- In Infancy and Childhood
KW  - Prospective Studies
KW  - Descriptive Statistics
KW  - Research Instruments
KW  - Convenience Sample
KW  - Kruskal-Wallis Test
KW  - Depression
KW  - Anxiety
KW  - Grief
KW  - Male
KW  - Female
KW  - Child
KW  - Human
SP  - 233
EP  - 239
JO  - AIDS Patient Care
JF  - AIDS Patient Care
JA  - AIDS PATIENT CARE
VL  - 9
IS  - 5
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 0893-5068
AD  - Pediatric HIV Psychosocial Support Program, Pediatric Branch, National Cancer Institute, Bethesda, MD
U2  - PMID: 11361403.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Stanley, Scott M.
AU  - Markman, Howard J.
AU  - Peters, Michelle St.
AU  - Leber, B. Douglas
T1  - STRENGTHENING MARRIAGES AND PREVENTING DIVORCE: NEW DIRECTIONS IN PREVENTION RESEARCH.
JO  - Family Relations
JF  - Family Relations
Y1  - 1995/10//
VL  - 44
IS  - 4
M3  - Article
SP  - 392
EP  - 401
SN  - 01976664
AB  - We highlight findings from the first 12 years of a longitudinal study of the prediction and prevention of marital distress and divorce and discuss new directions in the dissemination and evaluation of an empirically based prevention program for couples. We summarize the history and state of our program and discuss the key issues and implications of moving an empirically validated intervention out of the laboratory and into settings where it can help a wider base of couples prevent marital breakdown. We then describe our pilot studies that investigate the dissemination and use of our preventive intervention with couples who marry within religious organizations and with expectant couples where the mother is at high risk for maternal depression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Family Relations is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LONGITUDINAL method
KW  - DOMESTIC relations
KW  - DISTRESS (Psychology)
KW  - COUPLES
KW  - MARRIED people
KW  - RELIGIOUS institutions
KW  - MARRIAGE
KW  - MENTAL depression
KW  - communication
KW  - divorce
KW  - marriage
KW  - prevention
KW  - psycho-education
N1  - Accession Number: 9511165357; Stanley, Scott M. 1 Markman, Howard J. 2,3 Peters, Michelle St. 4 Leber, B. Douglas 5; Affiliation:  1: Co-director, Center for Marital and Family Studies, University of Denver, Department of Psychology, University of Denver, Denver, CO 80208  2: Professor of psychology, University of Denver  3: Director, Center for Marital and Family Studies  4: Post doctoral fellow, National Institute of Mental Health, Family Research Consortium, Department of Psychology, University of Denver  5: Post doctoral research associate, Department of Psychology, University of Denver; Source Info: Oct95, Vol. 44 Issue 4, p392; Subject Term: LONGITUDINAL method; Subject Term: DOMESTIC relations; Subject Term: DISTRESS (Psychology); Subject Term: COUPLES; Subject Term: MARRIED people; Subject Term: RELIGIOUS institutions; Subject Term: MARRIAGE; Subject Term: MENTAL depression; Author-Supplied Keyword: communication; Author-Supplied Keyword: divorce; Author-Supplied Keyword: marriage; Author-Supplied Keyword: prevention; Author-Supplied Keyword: psycho-education; NAICS/Industry Codes: 813110 Religious Organizations; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 10833
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bahro, Marcel
AU  - Silber, Earle
AU  - Box, Paulette
AU  - Sunderland, Trey
T1  - Giving up in Alzheimer's Disease--An Integrative Therapeutic Approach.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1995/10//
VL  - 10
IS  - 10
M3  - Article
SP  - 871
EP  - 874
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - For patients with Alzheimer's disease (AD). a recommendation to stop operating a motor vehicle can be a serious event complicated by a loss of sell-esteem and personal dignity. Patients are often reluctant to give up an activity so essential, both practically and symbolically, to independent living. We describe here a patient with moderately progressed AD who lacked insight of his need to cease driving. Through an integrative treatment approach, combining behavioral and psychodynamic modalities, we helped him to formulate effective ways of coping with his loss of access to independent transportation. We favor a psychotherapeutic strategy that combines behavioral and managerial measures with dynamic patient interaction, thereby developing the patient's insight of the need to give up driving while fostering his sense of autonomy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALZHEIMER'S disease
KW  - PSYCHOMETRICS
KW  - PSYCHODYNAMIC psychotherapy
KW  - ADJUSTMENT (Psychology)
KW  - BEHAVIORAL assessment
KW  - PSYCHOTHERAPY
KW  - Alzheimer's disease
KW  - autonomy
KW  - driving
KW  - independence
KW  - loss
KW  - mourning.
KW  - psychotherapy
KW  - self-esteem
N1  - Accession Number: 12119883; Bahro, Marcel 1 Silber, Earle 2 Box, Paulette 1 Sunderland, Trey 1; Affiliation:  1: National Institute of Mental Health, Bethesda, Maryland, USA.  2: Washington Psychoanalytic Institute, Washington, DC, USA.; Source Info: Oct1995, Vol. 10 Issue 10, p871; Subject Term: ALZHEIMER'S disease; Subject Term: PSYCHOMETRICS; Subject Term: PSYCHODYNAMIC psychotherapy; Subject Term: ADJUSTMENT (Psychology); Subject Term: BEHAVIORAL assessment; Subject Term: PSYCHOTHERAPY; Author-Supplied Keyword: Alzheimer's disease; Author-Supplied Keyword: autonomy; Author-Supplied Keyword: driving; Author-Supplied Keyword: independence; Author-Supplied Keyword: loss; Author-Supplied Keyword: mourning.; Author-Supplied Keyword: psychotherapy; Author-Supplied Keyword: self-esteem; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kirtschig, Gudula
AU  - Marinkovich, M. Peter
AU  - Burgeson, Robert E.
AU  - Yancey, Kim B.
T1  - Anti-Basement Membrane Autoantibodies in Patients with Anti-Epiligrin Cicatricial Pemphigoid Bind the α Subunit of Laminin 5.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1995/10//
VL  - 105
IS  - 4
M3  - Article
SP  - 543
EP  - 548
SN  - 0022202X
AB  - Recent studies have identified a group of cicatricial pemphigoid patients who have IgG anti-basement membrane autoantibodies that recognize epiligrin, a set of disulfide-linked polypeptides closely related if not identical to laminin 5 (formerly called kalinin, nicein, or BM600). To further understand the pathophysiology of blister formation in these patients, we have sought to identify the specific polypeptide(s) targeted by their autoantibodies. Comparative studies show that sera from these patients (nine of nine), P1E1 monoclonal anti-epiligrin antibody, and polyclonal as well as monoclonal anti-laminin 5 antibodies immunoprecipitate the same set of disulfide-linked polypeptides from media of biosynthetically radiolabeled human keratinocytes. Moreover, sera from eight of nine patients with anti-epiligrin cicatricial pemphigoid immunoblot the α subunit of laminin 5 but show no reactivity to its β or γ subunits. In addition, circulating IgG from a representative patient was affinity-purified against the α subunit of laminin 5 and shown to bind the dermal side of 1 M NaCl split skin in the same manner as autoantibodies from all patients with anti-epiligrin cicatricial pemphigoid. Sera from patients with bullous pemphigoid (n = 5), other forms of cicatricial pemphigoid (n = 5), epidermolysis bullosa acquisita (n = 4), or bullous systemic lupus erythematosus (n = 1) show no reactivity against any subunit of this laminin isoform in immunoprecipitation or immunoblot experiments. These findings correlate with prior reports showing that a monoclonal antibody directed against the α subunit of laminin 5 (i.e., laminin subunit α3) induces detachment of human keratinocytes from extracellular matrix <em>in vitro</em> as well as epidermis from human skin <em>in situ</em>. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOANTIBODIES
KW  - IMMUNOGLOBULINS
KW  - PEPTIDE hormones
KW  - MONOCLONAL antibodies
KW  - KERATINOCYTES
KW  - IMMUNOASSAY
N1  - Accession Number: 12323431; Kirtschig, Gudula 1 Marinkovich, M. Peter 2 Burgeson, Robert E. 3 Yancey, Kim B. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: Department of Dermatology, Oregon Health Sciences University, Shriner's Hospital for Crippled Children, Portland, Oregon.  3: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, U.S.A.; Source Info: Oct95, Vol. 105 Issue 4, p543; Subject Term: AUTOANTIBODIES; Subject Term: IMMUNOGLOBULINS; Subject Term: PEPTIDE hormones; Subject Term: MONOCLONAL antibodies; Subject Term: KERATINOCYTES; Subject Term: IMMUNOASSAY; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12323431
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104789225
T1  - Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain.
AU  - Iadarola, M J
AU  - Max, M B
AU  - Berman, K F
AU  - Byas-Smith, M G
AU  - Coghill, R C
AU  - Gracely, R H
AU  - Bennett, G J
Y1  - 1995/10//1995 Oct
N1  - Accession Number: 104789225. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Dominance, Cerebral -- Physiology
KW  - Neuralgia -- Physiopathology
KW  - Thalamus -- Physiopathology
KW  - Tomography, Emission-Computed -- Methods
KW  - Adult
KW  - Aged
KW  - Case Control Studies
KW  - Chronic Disease
KW  - Female
KW  - Human
KW  - Image Processing, Computer Assisted
KW  - Male
KW  - Middle Age
KW  - Neuralgia -- Radiography
KW  - Thalamus -- Radiography
SP  - 55
EP  - 64
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 63
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 8577491.
DO  - 10.1016/0304-3959(95)00015-K
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854791
T1  - Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth.
AU  - Ghosh P
AU  - Komschlies KL
AU  - Cippitelli M
AU  - Longo DL
AU  - Subleski J
AU  - Ye J
AU  - Sica A
AU  - Young HA
AU  - Wiltrout RH
AU  - Ochoa AC
Y1  - 1995/10/04/
N1  - Accession Number: 105854791. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Neoplasms -- Immunology
KW  - Spleen -- Immunology
KW  - T Lymphocytes -- Metabolism
KW  - Animals
KW  - Carcinoma, Renal Cell -- Immunology
KW  - Colonic Neoplasms -- Immunology
KW  - Disease Progression
KW  - DNA -- Metabolism
KW  - Documentation
KW  - Electrophoresis
KW  - Immunoglobulins -- Analysis
KW  - Interferons -- Analysis
KW  - Interleukin 2 -- Analysis
KW  - Kidney Neoplasms -- Immunology
KW  - Lymphokines
KW  - Mice
KW  - Nucleotides
KW  - Phenotype
SP  - 1478
EP  - 1483
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 19
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Cancer Institute-Frederick Cancer Research and Development Center, Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201, USA.
U2  - PMID: 7674335.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Gardner, Renee V.
AU  - Voloshin, Oleg N.
AU  - Camerini-Otero, R. Daniel
T1  - The identification of the single-stranded DNA-binding domain of the <em>Escherichia coli</em> RecA protein.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/10/15/
VL  - 233
IS  - 2
M3  - Article
SP  - 419
EP  - 425
PB  - Wiley-Blackwell
SN  - 00142956
AB  - To identify the ssDNA-binding domain of Escherichia coli RecA protein, we examined the ssDNA-binding capabilities of synthetic peptides, the sequences of which were derived from the C- and N-termini and from sequences within loops L1 and L2 of the RecA molecule identified from the crystal structure. Synthetic peptides derived from amino acid residues 185–219 of several bacterial RecA proteins, which include loop L2 of RecA, bound to ssDNA in filter-binding assays, whereas three separate synthetic peptides corresponding to single point mutants of E. coti RecA in this region did not. The binding of RecA to ssDNA examined using a gel-shill assay was inhibited by a synthetic peptide derived from this ssDNA-binding region, but not by synthetic peptides derived from amino acid residues 301–329 of the C-terminus or from N-terminal residues 6–39. A peptide corresponding to amino acid positions 152–169 of the RecA molecule and spanning loop L1 and its flanking regions did not bind ssDNA at peptide concentrations up to 250 μM. We have also defined a synthetic 20-amino-acid peptide that comprises amino acid residues 193–212 and includes loop L2 of RecA as the minimum unit that can bind to ssDNA from this region of RecA. Finally, two maltose-binding protein-RecA fusion proteins were made, one containing amino acid residues 185–224 of RecA and the other the last 51 C-terminal residues of RecA (amino acid residues 303–353). In contrast to the C-terminus-derived fusion protein, the fusion protein containing the putative DNA-binding site demonstrated significant binding to single-stranded oligonucleotides in both filter-binding and gel-shift assays. These findings suggest that a portion of the region extending from amino acid residues 193–212 is either part of or the whole ssDNA-binding domain of the RecA protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA-binding proteins
KW  - PEPTIDES
KW  - ADENOSINE triphosphatase
KW  - PROTEINS
KW  - BIOMOLECULES
KW  - AMINO acids
KW  - ESCHERICHIA coli
KW  - BIOCHEMISTRY
KW  - filter binding
KW  - homologous recombination
KW  - reca protein
KW  - single-stranded dna binding
KW  - synthetic peptides
N1  - Accession Number: 12693567; Gardner, Renee V. 1 Voloshin, Oleg N. 1 Camerini-Otero, R. Daniel 1; Affiliation:  1: Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 10/15/95, Vol. 233 Issue 2, p419; Subject Term: DNA-binding proteins; Subject Term: PEPTIDES; Subject Term: ADENOSINE triphosphatase; Subject Term: PROTEINS; Subject Term: BIOMOLECULES; Subject Term: AMINO acids; Subject Term: ESCHERICHIA coli; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: filter binding; Author-Supplied Keyword: homologous recombination; Author-Supplied Keyword: reca protein; Author-Supplied Keyword: single-stranded dna binding; Author-Supplied Keyword: synthetic peptides; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Friedman, Alfred S.
AU  - Granick, Samuel
AU  - Bransfield, Shirley
AU  - Kreisher, Cheryl
AU  - Khalsa, Jag
T1  - Gender Differences in Early Life Risk Factors for Substance Use/Abuse: A Study of an African-American Sample.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1995/11//
VL  - 21
IS  - 4
M3  - Article
SP  - 511
EP  - 531
SN  - 00952990
AB  - Gender differences in risk and protective factors for substance use/abuse in early adulthood were studied. Comprehensive systematic data on African-American males (N = 318) and females (N = 322), from birth to 7 years of age, were available from the National Collaborative Perinatal Study. These subjects were retrieved for assessment at average age 24. There are more differences between males and females than there are similarities in regard to the early childhood variables that predict substance use in early adulthood. However, high activity and intensity of response during infancy (measured at 8 months of age) was found to predict later substance use for both males and females. This type of behavior is considered by us to be a trait of temperament and to suggest the possibility of a genetic predisposition. More risk factors were found for female than for males. The risk factors for females were primarily of two types: 1) Related to experiences with mother and with the family environment; and 2) Poor levels of intellectual functioning and academic performance, and abnormal mental status. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AGE groups
KW  - GENETICS
KW  - SUBSTANCE abuse -- Risk factors
KW  - DRUG abuse
KW  - AFRICAN Americans
KW  - SEX differences (Biology)
KW  - GENETIC aspects
N1  - Accession Number: 9511161106; Friedman, Alfred S. 1 Granick, Samuel 1 Bransfield, Shirley 1 Kreisher, Cheryl 1 Khalsa, Jag 2; Affiliation:  1: Belmont Center for Comprehensive Treatment, Philadelphia, Pennsylvania.  2: Division of Epidemiology and Prevention Research, National Institute on Drug Abuse, Bethesda, Maryland.; Source Info: Nov95, Vol. 21 Issue 4, p511; Subject Term: AGE groups; Subject Term: GENETICS; Subject Term: SUBSTANCE abuse -- Risk factors; Subject Term: DRUG abuse; Subject Term: AFRICAN Americans; Subject Term: SEX differences (Biology); Subject Term: GENETIC aspects; Number of Pages: 21p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107362897
T1  - Psychosocial factors associated with fruit and vegetable consumption.
AU  - Krebs-Smith SM
AU  - Heimendinger J
AU  - Patterson BH
AU  - Subar AF
AU  - Kessler R
AU  - Pivonka E
AU  - Krebs-Smith, S M
AU  - Heimendinger, J
AU  - Patterson, B H
AU  - Subar, A F
AU  - Kessler, R
AU  - Pivonka, E
Y1  - 1995/11//1995 Nov-Dec
N1  - Accession Number: 107362897. Language: English. Entry Date: 19960301. Revision Date: 20161127. Publication Type: journal article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 8701680. 
KW  - Fruit
KW  - Vegetables
KW  - Food Habits
KW  - Food Preferences
KW  - Health Promotion
KW  - Nutrition Education
KW  - Telephone
KW  - Surveys
KW  - Descriptive Statistics
KW  - Regression
KW  - Pearson's Correlation Coefficient
KW  - Health Beliefs
KW  - Nutritional Requirements
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 98
EP  - 104
JO  - American Journal of Health Promotion
JF  - American Journal of Health Promotion
JA  - AM J HEALTH PROMOT
VL  - 10
IS  - 2
PB  - Sage Publications Inc.
AB  - Purpose: This study examined the relationship between various psychosocial factors and fruit and vegetable consumption.Design: The 5 A Day Baseline Survey, conducted in August 1991, just before the initiation of the 5 A Day for Better Health Program, obtained data on adults' intakes of, and their knowledge, perceptions, and attitudes regarding, fruits and vegetables.Setting: The survey was conducted by telephone.Subjects: Subjects were 2811 adults (response rate, 43%) aged 18 years and older in the 48 coterminous United States.Measures: Fruit and vegetable intake was measured as self-reported frequency of use; most of the psychosocial variables were measured using Likert scales.Results: This study estimates that only 8% of American adults thought that five or more servings of fruits and vegetables were needed for good health. Of the factors studied, the most important in determining someone's fruit and vegetable intake were the number of servings they thought they should have in a day, whether they liked the taste, and whether they had been in the habit of eating many fruits and vegetables since childhood. These few factors accounted for 15% more of the variation in fruit and vegetable consumption than did demographic variables alone (8%).Conclusions: Nutrition education should stress the need to eat five or more servings of fruits and vegetables per day because few adults are aware of this recommendation and such knowledge is strongly associated with increased intake. Furthermore, efforts to increase the palatability of fruits and vegetables, especially among children, should be promoted.
SN  - 0890-1171
AD  - National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, MD 20892, USA
AD  - National Cancer Institute, Division of Cancer Prevention and Control, 9000 Rockville Pike, EPN 313, Bethesda, MD 20892
U2  - PMID: 10160052.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107376256
T1  - Measurement of lactose consumption reliability and comparison of two methods.
AU  - Cooper GS
AU  - Busby MG
AU  - Fairchild AP
AU  - Cooper, G S
AU  - Busby, M G
AU  - Fairchild, A P
Y1  - 1995/11//1995 Nov
N1  - Accession Number: 107376256. Language: English. Entry Date: 19960701. Revision Date: 20161127. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: Food-Frequency Questionnaires (Willett et al). Grant Information: RR00046/RR/NCRR NIH HHS/United States. NLM UID: 9100013. 
KW  - Diet -- Evaluation
KW  - Lactose
KW  - Funding Source
KW  - Diet Records
KW  - Self Report
KW  - Validation Studies
KW  - Questionnaires
KW  - Software
KW  - Data Analysis Software
KW  - Paired T-Tests
KW  - Pearson's Correlation Coefficient
KW  - Descriptive Statistics
KW  - Confidence Intervals
KW  - Reliability
KW  - Test-Retest Reliability
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Human
SP  - 473
EP  - 477
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 5
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - The objective of this study was to assess the reliability of lactose consumption measured with a food-frequency questionnaire and to compare food-frequency data to prospectively recorded data. A self-administered food-frequency questionnaire (FF1) was completed by 295 women ages 38 to 49. Two months later, 75 received the same food-frequency questionnaire (FF2), and 75 received a 1-week diet diary listing 23 commonly eaten lactose-containing foods. Estimated mean intake of lactose was 16.1 g/d with FF1. Intake was slightly (but not significantly) higher at follow-up: Mean difference (95% confidence interval) was 1.4 (-0.8, 3.7) g/d for FF2 versus FF1, and 0.5 g (1.3, 2.3) g/d for the diet diary versus FF1. A moderate level of correlation was found: r = 0.57 between FF1 and FF2, and r = 0.65 between FF1 and the diet diary. Smaller subsets of items (n = 15 and n = 7) could be used to estimate lactose, with 89% and 82% agreement within tertiles, respectively. Since relatively few foods contain substantial amounts of lactose, a limited food-frequency or structured diary may be useful in research studies on the association between lactose consumption and ovarian cancer or other diseases.
SN  - 1047-2797
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
AD  - Epidemiology Branch MD A3-05, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709
U2  - PMID: 8680610.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107376262
T1  - Serum zinc and serum lipid profiles in 778 adults.
AU  - Hiller R
AU  - Seigel D
AU  - Sperduto RD
AU  - Blair N
AU  - Burton TC
AU  - Farber MD
AU  - Gragoudas ES
AU  - Gunter EW
AU  - Haller J
AU  - Seddon JM
AU  - Sowell AL
AU  - Yannuzzi LA
Y1  - 1995/11//1995 Nov
N1  - Accession Number: 107376262. Corporate Author: Eye Disease Case-Control Study Group. Language: English. Entry Date: 19960701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Supported by contracts N01-EY-5-2110, N01-EY-5-2109, N01-EY-5-2111, N01-EY-9-2105, N01-EY-5-2108, and N01-EY-7-2104 from the National Institutes of Health, Bethesda, MD. NLM UID: 9100013. 
KW  - Zinc -- Analysis
KW  - Lipoproteins -- Analysis
KW  - Funding Source
KW  - Cholesterol -- Analysis
KW  - Triglycerides -- Analysis
KW  - Lipoproteins, HDL Cholesterol -- Analysis
KW  - Lipoproteins, LDL Cholesterol -- Analysis
KW  - Cross Sectional Studies
KW  - Control Group
KW  - Multiple Logistic Regression
KW  - Odds Ratio
KW  - Analysis of Covariance
KW  - Descriptive Statistics
KW  - Confidence Intervals
KW  - Statistical Significance
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 490
EP  - 496
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 5
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - There has been increasing use of high-dosage zinc supplementation in the population, in particular a as a potential treatment for age-related macular degeneration. We examined the relationship between fasting serum zinc and serum lipid levels in 778 adults, aged 22 to 80 years, who were control subjects in a multicenter, clinic-based case-control study. The samples were taken during 1987 to 1990, a time when vitamin/mineral supplementation was becoming increasingly common. We found that higher serum zinc levels, most notably those above the highest quintile, were associated with higher levels of total serum cholesterol, low-density-lipoprotein cholesterol, and triglycerides. No significant trend was noted for high-density-lipoprotein cholesterol. Previous studies demonstrated that high-dosage zinc supplements raise serum zinc levels. The possibility that use of such supplements can adversely affect serum lipid profiles suggests that chronic ingestion of such supplements should not be done without adequate medical supervision.
SN  - 1047-2797
AD  - Division of Biometry and Epidemiology, National Eye Institute, Building 31, Room 6A52, National Institutes of Health, 31 Center Drive, MSC 2510, Bethesda, MD 20892-2510
U2  - PMID: 8680613.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107361826
T1  - The relative safety of gamma-ray, autoclave, and ethylene oxide gas sterilization of thermosetting polyurethane.
AU  - Shintani H
AU  - Shintani, H
Y1  - 1995/11//1995 Nov-Dec
N1  - Accession Number: 107361826. Language: English. Entry Date: 19960301. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560. 
KW  - Polyurethanes
KW  - Sterilization and Disinfection -- Adverse Effects
KW  - Gamma Rays
KW  - Ethylene Oxide
KW  - Carcinogens
KW  - Occupational Exposure
KW  - Carcinogens -- Analysis
KW  - Descriptive Statistics
KW  - Chromatography
KW  - Dialysis Equipment and Supplies
KW  - Human
SP  - 513
EP  - 519
JO  - Biomedical Instrumentation & Technology
JF  - Biomedical Instrumentation & Technology
JA  - BIOMED INSTRUM TECHNOL
VL  - 29
IS  - 6
CY  - Lawrence, Kansas
PB  - Allen Press Publishing Services Inc.
AB  - Sterilization of polyurethane (PU) produces 4,4'-methylenedianiline (MDA), a known carcinogen, and various other compounds. The relationships of the components of PU to the formation of these compounds by sterilization were studied. Specimens of PU fabricated from different combinations of isocyanates and polyols were obtained from dialyzers. The molecular weight of the particular polyol was found to influence the production of MDA by sterilization. Sterilization also produced many unidentified compounds. MDA production was not always associated with the production of the other compounds. Compared with gamma-ray irradiation and ethylene oxide gas (EOG) sterilization, autoclave sterilization eluted more hydrophilic compounds. This phenomenon was significant for PUs produced from smaller-molecular-weight polyols. The combination of autoclave sterilization and a PU produced from a larger-molecular-weight polyol is recommended to minimize the production of potentially toxic compounds. Of the techniques studied, EOG sterilization produced the least amounts of MDA and the other compounds, but the residue of EOG is itself problematic. The risk posed by the amounts of MDA extracted was not significant, but the biological safety of the other compounds remains to be determined.
SN  - 0899-8205
AD  - Section of Medical Devices, National Institute of Sciences, Tokyo, Japan
AD  - National Institutes of Health Sciences, 1-18-1, Kamiyoga, Setagaya, Tokyo 158, Japan
U2  - PMID: 8574266.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wallace, Kimberlee K.
AU  - Zhuo-Yao Bao, Kimberlee K.
AU  - Hong Dai, Kimberlee K.
AU  - Digate, Russell
AU  - Schuler, Gregory
AU  - Speedie, Marilyn K.
AU  - Reynolds, Kevin A.
T1  - Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1995/11//11/1/95
VL  - 233
IS  - 3
M3  - Article
SP  - 954
EP  - 962
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Describes the purification and characterization of a crotonyl-CoA reductase from Streptomyces collinus.  Butyrate metabolism; Fatty acid biosynthesis; Cloning, sequencing and expression of the corresponding gene in Escherichia coli.
KW  - COENZYMES
KW  - STREPTOMYCES
KW  - METABOLISM
KW  - FATTY acids
KW  - BIOSYNTHESIS
KW  - ESCHERICHIA coli
N1  - Accession Number: 12151995; Wallace, Kimberlee K. 1 Zhuo-Yao Bao, Kimberlee K. 1 Hong Dai, Kimberlee K. 1 Digate, Russell 2 Schuler, Gregory 3 Speedie, Marilyn K. 1 Reynolds, Kevin A. 1; Affiliation:  1: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore  2: Medical Biotechnology Center, Maryland Biotechnology Institute, University of Maryland, Baltimore  3: National Center for Biotechnology Information, National Institutes of Health, Bethesda; Source Info: 11/1/95, Vol. 233 Issue 3, p954; Subject Term: COENZYMES; Subject Term: STREPTOMYCES; Subject Term: METABOLISM; Subject Term: FATTY acids; Subject Term: BIOSYNTHESIS; Subject Term: ESCHERICHIA coli; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Barker, William
AU  - Andrich, Mary
AU  - Alexander, H.
AU  - Fraker, Douglas
T1  - Continuous intraoperative external monitoring of perfusate leak using iodine-131 human serum albumin during isolated perfusion of the liver and limbs.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1995/11//
VL  - 22
IS  - 11
M3  - Article
SP  - 1242
EP  - 1248
SN  - 03406997
N1  - Accession Number: 71154647; Barker, William 1 Andrich, Mary 1 Alexander, H. 2 Fraker, Douglas 2; Affiliation:  1: Nuclear Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, 20892 Bethesda USA  2: Surgery Branch, National Cancer Institute, National Institutes of Health, 20892 Bethesda USA; Source Info: Nov1995, Vol. 22 Issue 11, p1242; Number of Pages: 7p; Document Type: Article
L3  - 10.1007/BF00801607
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Costa Jr., Paul T.
T1  - Trait explanations in personality psychology.
JO  - European Journal of Personality
JF  - European Journal of Personality
Y1  - 1995/11//
VL  - 9
IS  - 4
M3  - Article
SP  - 231
EP  - 252
PB  - John Wiley & Sons, Inc.
SN  - 08902070
AB  - Recent debates on the status of contemporary trait psychology (Pervin, 1994) have revived old questions about the role of traits in the explanation of behavior: are traits mere descriptions of behavior, or do they offer one legitimate and useful form of explanation? We review the logic of trait explanation and present a general model of the person in which personality traits are hypothetical constructs regarded as basic dispositions. In interaction with external influences—notably shared meaning systems—traits contribute causally to the development of habits, attitudes, skills, and other characteristic adaptations. In this model, action and experience can be explained directly or proximally in terms of the interaction of the immediate situation with the individual's characteristics adaptations, and indirectly or distally in terms of underlying personality traits. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Personality is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEBATES & debating
KW  - PERSONALITY
KW  - ATTITUDE (Psychology)
KW  - CHARACTERS & characteristics
KW  - BEHAVIOR
KW  - SOCIAL sciences
N1  - Accession Number: 12084412; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation:  1: Gerontology Research Center, National Institute of Aging, NIH, Baltimore, MD, USA; Source Info: Nov95, Vol. 9 Issue 4, p231; Subject Term: DEBATES & debating; Subject Term: PERSONALITY; Subject Term: ATTITUDE (Psychology); Subject Term: CHARACTERS & characteristics; Subject Term: BEHAVIOR; Subject Term: SOCIAL sciences; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cosma, Christine L.
AU  - Danese, Paul N.
AU  - Carlson, John H.
AU  - Silhavy, Thomas J.
AU  - Snyder, William B.
T1  - Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1995/11//
VL  - 18
IS  - 3
M3  - Article
SP  - 491
EP  - 505
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The processing-defective outer membrane porin protein LamBA23D (Carlson and Silhavy, 1993) and a tripartite fusion protein, LamB-LacZ-PhoA (Snyder and Silhavy, 1995), are both secreted across the cytoplasmic membrane of <em>Escherichia coli</em>, where they exert an extracytoplasmic toxicity. Suppressors of these toxicities map to a previously characterized gene, <em>cpxA</em>, that encodes the sensor kinase protein of a two-component regulatory system. These activated <em>cpxA</em> alleles, designated as <em>cpxA</em>*, stimulate transcription of the periplasmic protease DegP (Danese <em>et al</em>., 1995), which in turn catalyses degradation of the tripartite fusion protein. In contrast, degradation of precursor LamBA23D is not significantly stimulated in a <em>cpxA</em>* suppressor background. In fact, increased levels of DegP in a wild-type background stabilized this protein. While a functional <em>degP</em> gene is required for full <em>cpxA</em>*-mediated suppression of both toxic envelope proteins, residual suppression is seen in <em>cpxA</em>* <em>degP</em>::Tn<em>10</em> double mutants. Furthermore, <em>cpxA</em>* mutations suppress the toxicity conferred by the LamB-LacZ hybrid protein, which exerts its effects in the cytoplasm, sequestered from DegP. Together, these observations suggest that the activated Cpx pathway regulates additional downstream targets that contribute to suppression. A subset of these targets may constitute a regulon involved in relieving extracytoplasmic and/or secretion-related stress. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Cell membranes
KW  - Bacterial genetics
KW  - Genes
KW  - Suppressor cells
N1  - Accession Number: 21302687; Cosma, Christine L. 1; Danese, Paul N. 1; Carlson, John H. 1,2; Silhavy, Thomas J. 1; Snyder, William B. 1,3; Affiliations: 1: Princeton University, Department of Molecular Biology, Lewis Thomas Laboratory, Princeton, New Jersey 08544, USA; 2: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA; 3: Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla, California 92093-0668, USA; Issue Info: Nov1995, Vol. 18 Issue 3, p491; Thesaurus Term: Escherichia coli; Thesaurus Term: Cell membranes; Thesaurus Term: Bacterial genetics; Subject Term: Genes; Subject Term: Suppressor cells; Number of Pages: 15p; Illustrations: 5 Diagrams, 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2011-03770-013
AN  - 2011-03770-013
AU  - Kordek, R.
AU  - Biernat, W.
AU  - Alwasiak, J.
AU  - Yanagihara, R.
AU  - Liberski, P. P.
T1  - Epidermal growth factor receptor and p53 protein expression in human glioblastomas.
JF  - European Journal of Neurology
JO  - European Journal of Neurology
JA  - Eur J Neurol
Y1  - 1995/11//
VL  - 2
IS  - 5
SP  - 487
EP  - 491
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 1351-5101
SN  - 1468-1331
AD  - Liberski, P. P., Laboratory of Electron Microscopy, Laboratories of Tumor Biology, Medical University of Lodz, 4 Paderewski Street, Lodz, Poland, 93-509
N1  - Accession Number: 2011-03770-013. PMID: 24283731 Partial author list: First Author & Affiliation: Kordek, R.; Department of Pathology, Medical University of Lodz, Lodz, Poland. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20110606. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Genetics; Mutations; Neoplasms; Proteins; Glioma. Minor Descriptor: Nerve Growth Factor; Neural Receptors; Growth Factor. Classification: Cancer (3293). Population: Human (10). Location: Poland. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Nov, 1995. Publication History: Accepted Date: May 27, 1995; First Submitted Date: Jan 12, 1995. Copyright Statement: Rapld Science Publishers. 1995. 
AB  - p53 mutations and amplification of epidermal growth factor receptor (EGFR) gene are the most frequently detected genetic alterations in glioblastomas; thus, these changes seem to delineate two subgroups of glioblastomas: those originated de novo and those originated from preexistent low grade astrocytomas. Paraffin-embedded surgical specimens of 30 human glioblastomas were analyzed immunohistochemically for the presence of p53 protein and EGFR Approximately half of the cases were p53 protein-positive while one-third were EGFR positive. Only three cases were positive for both p53 protein and EGFR There was no difference between the average ages of patients with only-p53-positive, and doublenegative tumors, while three glioblastomas with both p53 protein and EGFR immunopositivity occured in older patients (mean age 67.0 years, p < 0.02). Patients with only-EGFR-positive tumors were younger, but not significantly (443 years, p < 0.1). This study supports the notion that there are two main subpopulations of glioblastoma—with EGFR and with p53 protein overexpression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - epidermal growth factor receptors
KW  - protein expression
KW  - glioblastomas
KW  - mutations
KW  - genetics
KW  - tumors
KW  - 1995
KW  - Genetics
KW  - Mutations
KW  - Neoplasms
KW  - Proteins
KW  - Glioma
KW  - Nerve Growth Factor
KW  - Neural Receptors
KW  - Growth Factor
KW  - 1995
U1  - Sponsor: Sponsor name not included. Grant: 517-11-01 7. Other Details: KBN grant. Recipients: No recipient indicated
U1  - Sponsor: Foundation for Polish Science, Poland. Recipients: No recipient indicated
DO  - 10.1111/j.1468-1331.1995.tb00161.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37546-039
AN  - 2015-37546-039
AU  - Dutton, E. K.
AU  - Uhm, C.-S.
AU  - Samuelsson, S. J.
AU  - Schaffner, A. E.
AU  - Fitzgerald, S. C.
AU  - Daniels, M. P.
T1  - Acetylcholine receptor aggregation at nerve-muscle contacts in mammalian cultures: Induction by ventral spinal cord neurons is specific to axons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/11//
VL  - 15
IS  - 11
SP  - 7401
EP  - 7416
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Daniels, M. P., Laboratory of Biochemical Genetics, NIH, Building. 36, Room lC-06, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37546-039. PMID: 7472493 Partial author list: First Author & Affiliation: Dutton, E. K.; Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Axons; Cholinergic Receptors; Dorsal Roots; Spinal Cord. Minor Descriptor: Acetylcholine; Muscles; Synapses. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 16. Issue Publication Date: Nov, 1995. Publication History: Accepted Date: Jul 13, 1995; Revised Date: Jul 7, 1995; First Submitted Date: Mar 3, 1995. Copyright Statement: Society for Neuroscience. 1995. 
AB  - We used a novel mammalian coculture system to study ACh receptor (AChR) redistribution and synaptic structure at nerve-muscle contacts. Ventral spinal cord (VSC) neurons were plated on cultures containing extensive myotubes but few fibroblasts. Neurite-induced redistribution of AChRs occurred within 6 hr after plating neurons and was maximal between 36-48 hr. This AChR redistribution appeared in two patterns: (1) AChR density at sites directly apposed to the neurite where neurites crossed preexisting AChR patches was sharply reduced, (2) Newly aggregated AChRs formed swaths lateral to the neurite path. VSC neurons induced more AChR aggregation than hippocampal, superior cervical ganglion and dorsal root ganglion neurons. The 43 and 58 kDa postsynaptic proteins were colocalized with AChR-enriched domains in all VSC neurite-induced aggregates whereas the colocalization of laminin was variable. Electron microscopy of regions with neurite-induced AChR aggregation showed postsynaptic membrane specializations characteristic of developing synapses and, in older cultures, features of more mature synaptic structure. Thus, the coculture system is useful for studying early stages of neuromuscular junction (NMJ) formation. Neurites in these cocultures were identified as axons or dendrites by morphological criteria and by their immunoreactivity for synaptophysin and phosphorylated heavy neurofilament subunits or for microtubule associated protein 2 (MAP2), respectively. Axons showed a 10-fold higher induction of AChR aggregation than did dendrites. Thus, at least one essential signaling molecule necessary for the induction of AChR aggregation at sites of interaction with muscle appears to be expressed in a polarized fashion in developing VSC neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuromuscular junction
KW  - ACh receptor
KW  - skeletal muscle
KW  - synapse
KW  - spinal cord neuron
KW  - cell culture
KW  - axon
KW  - dendrite
KW  - 1995
KW  - Axons
KW  - Cholinergic Receptors
KW  - Dorsal Roots
KW  - Spinal Cord
KW  - Acetylcholine
KW  - Muscles
KW  - Synapses
KW  - 1995
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107370110
T1  - Alcohol and energy intake. Proceedings of a symposium held in Beltsville, MD, May 8-11, 1994.
AU  - Lands WEM
Y1  - 1995/11/02/Nov95 Supplement
N1  - Accession Number: 107370110. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; proceedings; review. Supplement Title: Nov95 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Ethanol -- Metabolism
KW  - Ethanol -- Pharmacodynamics
KW  - Energy Intake
KW  - Liver -- Drug Effects
KW  - Body Mass Index
KW  - Body Weight -- Drug Effects
KW  - Cells -- Metabolism
KW  - Female
SP  - 1101S
EP  - 6S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 62
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD
U2  - PMID: 7484928.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Blumenthal, M. N.
AU  - Banks-Schlegel, S.
AU  - Bleecker, E. R.
AU  - Marsh, D. G.
AU  - Ober, C.
T1  - Collaborative studies on the genetics of asthma -- National Heart, Lung and Blood Institute.
JO  - Clinical & Experimental Allergy
JF  - Clinical & Experimental Allergy
Y1  - 1995/11/02/Nov1995 Supplement 2
VL  - 25
M3  - Article
SP  - 29
EP  - 32
PB  - Wiley-Blackwell
SN  - 09547894
AB  - Discusses the Collaborative Study on the Genetics of Asthma (CSGA), initiated by the National Heart, Lung and Blood Institute with input from the National Institute of Allergy and Infectious Diseases in the United States. Aims of CSGA; Study design and protocol; Study of phenotyping and genotyping.
KW  - ASTHMA -- Genetic aspects
KW  - LUNG diseases
KW  - BRONCHIAL diseases
KW  - RESPIRATORY allergy
KW  - PHENOTYPE
KW  - UNITED States
N1  - Accession Number: 16277696; Blumenthal, M. N. 1 Banks-Schlegel, S. 2 Bleecker, E. R. 3 Marsh, D. G. 4 Ober, C. 5; Affiliation:  1: University of Minnesota, Section of Allergy, Department of Medicine, Minneapolis, Minnesota  2: National Heart, Lung and Blood Institute, Airways Disease Branch, Bethesda, Maryland  3: University of Maryland School of Medicine, Baltimore, Maryland  4: Johns Hopkins University School of Medicine, Baltimore, Maryland  5: Department of Obstetrics and Gynaecology, University of Chicago, Illinois, USA; Source Info: Nov1995 Supplement 2, Vol. 25, p29; Subject Term: ASTHMA -- Genetic aspects; Subject Term: LUNG diseases; Subject Term: BRONCHIAL diseases; Subject Term: RESPIRATORY allergy; Subject Term: PHENOTYPE; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107333411
T1  - Identifying substance abuse in primary care.
AU  - Haverkos HW
AU  - Stein MD
Y1  - 1995/11/15/
N1  - Accession Number: 107333411. Language: English. Entry Date: 19970801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646. 
KW  - Primary Health Care
KW  - Substance Abuse -- Therapy
KW  - Substance Abuse -- Prevention and Control
KW  - Health Screening
KW  - Substance Abuse -- Diagnosis
SP  - 2029
EP  - 2035
JO  - American Family Physician
JF  - American Family Physician
JA  - AM FAM PHYSICIAN
VL  - 52
IS  - 7
CY  - Skokie, Illinois
PB  - American Academy of Family Physicians
SN  - 0002-838X
AD  - National Institute on Drug Abuse, Rockville, Maryland
U2  - PMID: 7484704.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107333411&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107394216
T1  - Steps toward gene therapy: 1. The initial trials.
AU  - Blaese RM
Y1  - 1995/11/15/
N1  - Accession Number: 107394216. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Gene Therapy
KW  - Severe Combined Immunodeficiency -- Therapy
KW  - Genes
KW  - Education, Continuing (Credit)
KW  - Retroviruses
KW  - RNA
KW  - DNA
SP  - 33
EP  - 83
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 30
IS  - 11
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - National Center for Human Genome Research, National Institutes of Health, Bethesda, Md
U2  - PMID: 8557801.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107394216&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854800
T1  - Proportion of breast cancer cases in the United States explained by well-established risk factors.
AU  - Madigan MP
AU  - Ziegler RG
AU  - Benichou J
AU  - Byrne C
AU  - Hoover RN
Y1  - 1995/11/15/
N1  - Accession Number: 105854800. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: National Health and Nutrition Examination Survey (NHANES). NLM UID: 7503089. 
KW  - Breast Neoplasms -- Epidemiology
KW  - Breast Neoplasms -- Etiology
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Breast Neoplasms
KW  - Female
KW  - Income
KW  - Middle Age
KW  - Parity
KW  - Pregnancy
KW  - Risk Factors
KW  - United States
SP  - 1681
EP  - 1685
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 22
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 7473816.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854800&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Torrey, E. Fuller
T1  - Editorial: Jails and Prisons--America's New Mental Hospitals.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/12//
VL  - 85
IS  - 12
M3  - Editorial
SP  - 1611
EP  - 1611
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the roles of jails as purveyors of public psychiatric services. According to a survey report, 6 to 15 percent of jail inmates are seriously mentally ill. Verbal abuse as well as physical assaults are usual experiences for seriously mentally ill prisoners. Law enforcement officials are spending improving amounts of their time and efforts responding to psychiatric problems in prisons. Deinstitutionalization of seriously mentally ill people has been the largest inefficient social experiment in the 20th century. The most common cause for jailing seriously mentally il lpeople were assault, theft and disorderly behavior.
KW  - CORRECTIONAL institutions
KW  - PRISONS
KW  - PRISONERS
KW  - MENTAL illness
KW  - MENTALLY ill
KW  - MENTALLY ill prisoners
N1  - Accession Number: 9601030437; Torrey, E. Fuller 1; Affiliation:  1: National Institute of Mental Health, Neuropsychiatric Research Hospital, Washington, DC.; Source Info: Dec1995, Vol. 85 Issue 12, p1611; Subject Term: CORRECTIONAL institutions; Subject Term: PRISONS; Subject Term: PRISONERS; Subject Term: MENTAL illness; Subject Term: MENTALLY ill; Subject Term: MENTALLY ill prisoners; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 3p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Krebs-Smith, Susan M.
AU  - Cook, Annetta
AU  - Subar, Amy F.
AU  - Cleveland, Linda
AU  - Friday, James
T1  - US Adults' Fruit and Vegetable Intakes, 1989 to 1991: A Revised Baseline for the Healthy People 2000 Objective.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/12//
VL  - 85
IS  - 12
M3  - Article
SP  - 1623
EP  - 1623
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study provides revised baseline data for the Healthy People 2000 objective related to fruit and vegetable intakes, accounting for fruits and vegetables from all sources and measuring servings in a manner consistent with current dietary guidance. Methods. Dietary data from 8181 adults in the US Department of Agriculture's 1989-1991 Continuing Surveys of Food Intakes by Individuals were examined. All foods were disaggregated into their component ingredients; all fruit and vegetable ingredients were assigned specific weights to correspond to a serving as defined by current dietary guidance materials; and the number of servings was tallied. Results. While mean intakes of fruits and vegetables--4.3 servings per day--were not far from the Year 2000 objective, only 32% of American adults' intakes met the objective. When more stringent standards were set either to compensate for higher calorie levels or to achieve the balance between fruits and vegetables suggested in current guidance, only 24% and 12%, respectively, met the recommendations. Conclusions. These results suggest a need to develop strategies for overcoming barriers to eating fruits and vegetables. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FOOD habits
KW  - FRUIT
KW  - VEGETABLES
KW  - HORTICULTURAL crops
KW  - UNITED States
KW  - UNITED States. Dept. of Agriculture
N1  - Accession Number: 9601030362; Krebs-Smith, Susan M. 1 Cook, Annetta 2 Subar, Amy F. 1 Cleveland, Linda 2 Friday, James 2; Affiliation:  1: National Cancer Institute, Bethesda  2: US Department of Agriculture, Hyattsville, Md.; Source Info: Dec1995, Vol. 85 Issue 12, p1623; Subject Term: FOOD habits; Subject Term: FRUIT; Subject Term: VEGETABLES; Subject Term: HORTICULTURAL crops; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Agriculture; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simpson, Kit N.
AU  - Biddle, Andrea K.
AU  - Rabinovich, N. Regina
T1  - A Model for Estimating the Impact of Changes in Children's Vaccines.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1995/12//
VL  - 85
IS  - 12
M3  - Article
SP  - 1666
EP  - 1666
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. To assist in strategic planning for the improvement of vaccines and vaccine programs, an economic model was developed and tested that estimates the potential impact of vaccine innovations on health outcomes and costs associated with vaccination and illness. Methods. A multistep, iterative process of data extraction/integration was used to develop the model and the scenarios. Parameter replication, sensitivity analysis, and expert review were used to validate the model. Results. The greatest impact on the improvement of health is expected to result from the production of less reactogenic vaccines that require fewer inoculations for immunity. The greatest economic impact is predicted from improvements that decrease the number of inoculations required. Conclusions. Scenario analysis may be useful for integrating health outcomes and economic data into decision making. For childhood infections, this analysis indicates that large cost savings can be achieved in the future if we can improve vaccine efficacy so that the number of required inoculations is reduced. Such an improvement represents a large potential "payback" for the United States and might benefit other countries. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL change
KW  - VACCINATION
KW  - IMMUNIZATION
KW  - CHILDREN -- Health
KW  - CHILD care
KW  - PUBLIC health
N1  - Accession Number: 9601030381; Simpson, Kit N. 1 Biddle, Andrea K. 1 Rabinovich, N. Regina 2; Affiliation:  1: Department of Health Policy and Administration, School of Public Health, University of North Carolina, Chapel Hill  2: Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md.; Source Info: Dec1995, Vol. 85 Issue 12, p1666; Subject Term: SOCIAL change; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: CHILDREN -- Health; Subject Term: CHILD care; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9601030381&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107373338
T1  - US adults' fruit and vegetable intakes, 1989 to 1991: a revised baseline for the Healthy People 2000 objective.
AU  - Krebs-Smith SM
AU  - Cook DA
AU  - Subar AF
AU  - Cleveland L
AU  - Friday J
Y1  - 1995/12//
N1  - Accession Number: 107373338. Language: English. Entry Date: 19960601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: 1989 to 1991 Continuing Surveys of Food Intakes by Individuals (CSFII). NLM UID: 1254074. 
KW  - Healthy People 2000
KW  - Health Policy -- Trends -- United States
KW  - Nutritional Requirements
KW  - Food Habits -- Evaluation -- In Adulthood
KW  - United States
KW  - Research Instruments
KW  - Fruit
KW  - Vegetables
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1623
EP  - 1629
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 85
IS  - 12
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - Objectives. This study provides revised baseline data for the Healthy People 2000 objective related to fruit and vegetable intakes, accounting for fruits and vegetables from all sources and measuring servings in a manner consistent with current dietary guidance. Methods. Dietary data from 8181 adults in the US Department of Agriculture's 1989-1991 Continuing Surveys of Food Intakes by Individuals were examined. All foods were disaggregated into their component ingredients; all fruit and vegetable ingredients were assigned specific weights to correspond to a serving as defined by current dietary guidance materials; and the number of servings was tallied. Results. While mean intakes of fruits and vegetables -- 4.3 servings per day were not far from the Year 2000 objective, only 32% of American adults' intakes met the objective. When more stringent standards were set either to compensate for higher calorie levels or to achieve the balance between fruits and vegetables suggested in current guidance, only 24% and 12%, respectively, met the recommendations. Conclusions. These results suggest a need to develop strategies for overcoming barriers to eating fruits and vegetables.
SN  - 0090-0036
AD  - National Cancer Institute, DCPC, Executive Plaza N, Rm 313, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892
U2  - PMID: 7503335.
DO  - 10.2105/AJPH.85.12.1623
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105853590
T1  - College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Summary. Members of the Cancer Committee.
AU  - Henson DE
AU  - Fielding LP
AU  - Grignon DJ
AU  - Page DL
AU  - Hammond ME
AU  - Nash G
AU  - Pettigrew NM
AU  - Gorstein F
AU  - Hutter RV
Y1  - 1995/12//1995 Dec
N1  - Accession Number: 105853590. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7607091. 
KW  - Neoplasms -- Diagnosis
KW  - Tumor Markers, Biological -- Analysis
KW  - Breast Neoplasms -- Diagnosis
KW  - Colonic Neoplasms -- Diagnosis
KW  - Diagnosis, Laboratory -- Classification
KW  - Diagnosis, Laboratory -- Standards
KW  - Female
KW  - Male
KW  - Neoplasms
KW  - Prognosis
KW  - Prostatic Neoplasms -- Diagnosis
SP  - 1109
EP  - 1112
JO  - Archives of Pathology & Laboratory Medicine
JF  - Archives of Pathology & Laboratory Medicine
JA  - ARCH PATHOL LAB MED
VL  - 119
IS  - 12
CY  - Northfield, Illinois
PB  - College of American Pathologists
SN  - 0003-9985
AD  - Early Detection Branch, National Cancer Institute, Bethesda, Md 20892, USA.
U2  - PMID: 7503658.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105853590&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
AU  - Mays, D. A.;
T1  - Pharmacotherapy related information resources accessible via the Internet
CT  - Pharmacotherapy related information resources accessible via the Internet
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - P
EP  - )
AD  - National Institutes of Health, Building 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 32-13446; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature
N2  - The Internet is a worldwide communications system that links an intricate series of networks owned and operated by government agencies, universities, schools, libraries, businesses, corporations, and not for profit organizations. Many information resources pertaining to drug therapy and clinical medicine are accessible via the Internet. These resources include large databases, public domain programs, and text files. Resources of interest to clinicians were categorized and briefly described. Procedures for identifying and locating relevant resources using various browsers and other Internet services were also outlined.
KW  - Practice Interest Areas--Drug and Poison Information--meeting presentations;
KW  - ASHP meeting abstracts--drug information, Internet;
KW  - Computers--drug information--Internet;
KW  - Drug information--computers--Internet;
KW  - Internet--drug information;
KW  - Databases--drug information--Internet;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13446&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Singh, K. K.;
AU  - Goad, K.;
AU  - Skarulis, M.;
AU  - Csako, G.;
AU  - Wesley, R.;
T1  - Pilot trial to evaluate the effects of thyroid hormone-induced changes in lipoprotein(a) (Lp(a)) on hemostasis in thyroid cancer patients
CT  - Pilot trial to evaluate the effects of thyroid hormone-induced changes in lipoprotein(a) (Lp(a)) on hemostasis in thyroid cancer patients
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - P
EP  - )
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Pharmacy Department Rm. 1N257, 10 Center Drive, Bethesda, MD 20892, USA
N1  - Accession Number: 32-13162; Language: English; Chemical Name: Levothyroxine--51-48-9; Therapeutic Class: (68:36.04); AHFS Class: Thyroid drugs levothyroxine; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Pharmacology
N2  - Elevated Lp(a) concentrations are associated with atherosclerosis and thrombosis and are inversely correlated with thyroid hormones (TH). According to standard management of thyroid cancer, patients discontinue levothyroxine suppression therapy (defined by subnormal thyrotropin concentrations) prior to scanning. The resulting extreme fluctuations in TH make these patients useful for observing effects of changes in Lp(a) concentration on hemostasis. Such information could help to further elucidate the role of Lp(a) in thrombotic disorders. This study involves thyroid cancer patients scheduled for radioiodine scanning. Hemostatic, thyroid and lipid panels including Lp(a) are done while patients are maintained on levothyroxine suppression. All laboratory panels are repeated at scan, and at weeks one and six of restarting suppression therapy.
KW  - Levothyroxine--thyroid neoplasms-;
KW  - Practice Interest Areas--Primary Care--meeting presentations;
KW  - ASHP meeting abstracts--levothyroxine effects, hemostasis;
KW  - Lipoproteins--levothyroxine--effects;
KW  - Thyroid neoplasms--levothyroxine--lipoproteins;
KW  - Thyroid drugs--levothyroxine--lipoproteins;
KW  - Hemostasis--levothyroxine--lipoproteins;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13162&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Turcasso, N. M.;
AU  - Auth, D. A.;
AU  - Calis, K. A.;
AU  - Anderson, D. W.;
AU  - Mays, D. A.;
AU  - Meyer, C. C.;
T1  - Survey of drug information centers for characteristics that may serve as quality indicators
CT  - Survey of drug information centers for characteristics that may serve as quality indicators
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - P
EP  - )
AD  - National Institutes of Health, Building 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 32-13449; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature
N2  - Drug information centers provide medication related information, pharmacotherapy consultations, and various support functions. We conducted a survey of all drug information centers in the United States to obtain characteristics that may serve as surrogate markers of quality. These data were presented in aggregate and will be used as part of a larger drug information center study to determine if these characteristics are related to the quality of the information provided by the centers.
KW  - Practice Interest Areas--Drug and Poison Information--meeting presentations;
KW  - ASHP meeting abstracts--drug information centers;
KW  - Quality assurance--drug information centers--indicators;
KW  - Data collection--drug information centers--quality assurance;
KW  - Drug information centers--quality assurance--indicators;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13449&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Minor, J. R.;
T1  - Alternative treatments in HIV management
CT  - Alternative treatments in HIV management
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - PI
EP  - 95
AD  - National Institutes of Health, Clinical Center Pharmacy Department, Building 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 32-13137; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug EvaluationsSociology, Economics and Ethics
N2  - Many HIV infected individuals are exploring alternative, nonconventional treatments for their disease, most as complementary therapies, but some in place of approved interventions. The putative therapeutic aspects, potential for harmful effects and adverse drug interactions, and economics of selected alternative therapies will be presented. Learning objectives: 1. Identify potential alternative therapies that may be utilized by HIV infected patients, and reasons why patients explore these therapies. 2. List resources available to obtain information on alternative, nonconventional therapies. 3. List potential risks that may result from taking alternative treatments. Self-assessment questions: 1. As many as 1 in 5 adult Americans have reported using unconventional therapies. 2. Reasons why HIV infected patients pursue alternative therapies include desperation, desire for empowerment, toxicities of approved treatments, and misleading advertising. 3. Pharmacists working with HIV infected patients who are pursuing alternative therapies should: (a) be aware of trends in the community; (b) help patients evaluate sources of information on these therapies; (c) advise against unsafe, ineffective therapies; (d) provide basic guidelines for general health promotion and reduction of disease transmission; (e) all. Answers: 1. (False) 2. (True) 3. (e)
KW  - ASHP meeting abstracts--HIV infections, alternative medicine;
KW  - Alternative medicine--HIV infections--therapy;
KW  - Toxicity--alternative medicine;
KW  - Costs--alternative medicine--HIV infections;
KW  - Drug interactions--alternative medicine--HIV infections;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13137&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Keravich, D. P.;
T1  - New and emerging technology for sterile compounding
CT  - New and emerging technology for sterile compounding
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - PI
EP  - 57
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
N1  - Accession Number: 32-12549; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Technology; Institutional Pharmacy Practice
N2  - The purpose of this presentation is to inform hospital practitioners on the status of the current technology as well as present new emerging technology as it related to establishing or maintaining a sterile compounding environment. Different pharmacy options for establishing a clean room or developing a clean room environment will be reviewed.
KW  - ASHP meeting abstracts--sterile products compounding;
KW  - Injections--compounding--standards;
KW  - Administration--hospital pharmacy--compounding;
KW  - Pharmacy, institutional, hospital--administration--compounding;
KW  - Sterile products--compounding--technology;
KW  - Technology--compounding--sterile products;
KW  - Aseptic areas--clean rooms--sterile products;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-12549&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Young, L. R.;
AU  - Calis, K. A.;
T1  - Clinically oriented drug information residency training
CT  - Clinically oriented drug information residency training
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - RTP
EP  - -24
AD  - National Institutes of Health, Building 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 32-13329; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education; Institutional Pharmacy PracticeInformation Processing and Literature
N2  - An innovative, clinically oriented drug information residency training program at the National Institutes of Health is described. The specialized residency in drug information practice and pharmacotherapy is a postgraduate experience in providing comprehensive drug information services with an emphasis on patient care. Patient specific pharmacotherapy and direct patient care are integrated into the daily practice of the drug information practitioners. The resident also participates in an ongoing clinical practice and serves as a member of the health care team. Other aspects of the residency program include opportunities to participate in clinical research, publish papers in the medical literature, and participate in clinical and didactic instruction of pharmacy students. The focus on direct patient care has attracted many applicants to the residency program because it allows the resident to expand his or her practice from that of dispensing information to providing extensive phar acotherapy consultations aimed at improving patients' clinical outcomes. While this concept is not novel, it has become particularly attractive with the expansion of entry-level doctor of pharmacy programs and the emergence of pharmaceutical care.
KW  - ASHP meeting abstracts--residencies;
KW  - Education, pharmaceutical--residencies--drug information;
KW  - Drug information--residencies;
KW  - Clinical pharmacy--residencies--drug information;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13329&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Byrd, D. C.;
AU  - Piscitelli, S. C.;
AU  - Wesley, R. A.;
AU  - Dorworth, T. E.;
AU  - Pucino, F.;
T1  - Primary care residency training in a biomedical research facility
CT  - Primary care residency training in a biomedical research facility
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1995/12/01/
VL  - 30
IS  - Dec
SP  - RTP
EP  - -25
AD  - National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 32-13359; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education; Information Processing and Literature
N2  - This presentation describes an innovative primary care residency with a unique emphasis in the areas of research, clinical computer applications, and teaching. In addition to the development of specialized skills in ambulatory care, the resident assumes the role of clinical investigator, computer programmer, and educator. Research activities include pharmacokinetic and pharmacodynamic modeling of investigational drugs, IRB participation, completion of graduate course work in biostatistics, and large scale distribution of investigational drugs. The resident also has the opportunity to design and implement novel computer applications such as neural networks for drug dosing, national database networks, and automative therapeutic drug monitoring. Teaching experiences include educating staff, precepting pharmacy residents, and lecturing to nursing pharmacology students. The resident's expanded role is a valuable training experience and an asset to the institution.
KW  - ASHP meeting abstracts--residencies;
KW  - Education, pharmaceutical--residencies--research;
KW  - Research--residencies;
KW  - Computers--education, pharmaceutical--residencies;
KW  - Primary care--residencies;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13359&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107373763
T1  - Treatment of mental disorders among nursing home residents: will the market provide?
AU  - Jakubiak CH Jr.
AU  - Callahan JJ Jr.
Y1  - 1995///Winter95
N1  - Accession Number: 107373763. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9426452. 
KW  - Mental Disorders -- Prevention and Control -- In Old Age
KW  - Nursing Home Patients
KW  - Health Policy -- Trends -- United States
KW  - Aged
KW  - Dementia, Senile
KW  - Depression -- Drug Therapy
KW  - Health Facility Environment
KW  - Problem Patients
KW  - United States
KW  - Inpatients
SP  - 39
EP  - 42
JO  - Generations
JF  - Generations
JA  - GENERATIONS
VL  - 19
IS  - 4
CY  - San Francisco, California
PB  - American Society on Aging
SN  - 0738-7806
AD  - National Institute of Mental Health Training Program in Mental Health Services Research, Heller School, Brandeis University, Waltham, Mass
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107373763&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lange, Nicholas
T1  - Nonparametric Regression and Generalized Linear Models: A Roughness Penalty Approach (Book).
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1995/12//
VL  - 90
IS  - 432
M3  - Book Review
SP  - 1489
SN  - 01621459
AB  - Reviews the book "Nonparametric Regression and Generalized Linear Models: A Roughness Penalty Approach," by P.J. Green and B.W. Silverman.
KW  - LINEAR models (Statistics)
KW  - NONFICTION
KW  - GREEN, P. J.
KW  - SILVERMAN, B. W.
KW  - NONPARAMETRIC Regression & Generalized Linear Models: A Roughness Penalty Approach (Book)
N1  - Accession Number: 9512295620; Lange, Nicholas 1; Affiliations: 1: National Institutes of Health.; Issue Info: Dec95, Vol. 90 Issue 432, p1489; Thesaurus Term: LINEAR models (Statistics); Subject Term: NONFICTION; Reviews & Products: NONPARAMETRIC Regression & Generalized Linear Models: A Roughness Penalty Approach (Book); People: GREEN, P. J.; People: SILVERMAN, B. W.; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 841
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107367163
T1  - Cancer in adults: a focus on prevention and detection in the nurse practitioner's practice.
AU  - Varricchio CG
Y1  - 1995/12//1995 Dec
N1  - Accession Number: 107367163. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; algorithm; tables/charts. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9100939. 
KW  - Neoplasms -- Prevention and Control -- In Adulthood
KW  - Nurse Practitioners
KW  - Cancer Screening -- In Adulthood
KW  - Neoplasms -- Physiopathology
KW  - Neoplasms -- Classification
KW  - Neoplasms -- Mortality
KW  - Risk Factors
KW  - Patient Education
KW  - Neoplasms -- Diagnosis
KW  - Neoplasm Staging
KW  - Neoplasms -- Therapy
KW  - Oncologic Nursing
KW  - Adult
SP  - 215
EP  - 220
JO  - Nurse Practitioner Forum
JF  - Nurse Practitioner Forum
JA  - NURSE PRACT FORUM
VL  - 6
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - This article provides a very general overview of the group of diseases called cancer. The clinical practice of the nurse practitioner emphasizes health maintenance and promotion of a healthy life style. This focus can carry over into the survival phase of the cancer experience. Counseling about risk status and risk reduction are an integral part of the total approach to cancer care. These activities can be integrated into standard care delivered by the nurse practitioner. (Copyright 1995 W.B. Saunders Company)
SN  - 1045-5485
AD  - National Cancer Institute, Division of Cancer Prevention and Control, 900 Rockville Pike, EPN 300, Bethesda, MD 20892
U2  - PMID: 8547811.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107367163&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107365276
T1  - Psychophysiologic factors contributing to functional performance in people with COPD: are there gender differences?
AU  - Leidy NK
AU  - Traver GA
Y1  - 1995/12//
N1  - Accession Number: 107365276. Language: English. Entry Date: 19960401. Revision Date: 20150818. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Sickness Impact Profile (SIP); Borg Scale of Perceived Exertion; Basic Need Satisfaction Inventory (BNSI); Modified Erikson Psychosocial Stage Inventory (MEPSI); Bronchitis-Emphysema Symptom checklist (BESC). Grant Information: American Lung Association. NLM UID: 7806136. 
KW  - Pulmonary Disease, Chronic Obstructive
KW  - Pulmonary Disease, Chronic Obstructive -- Psychosocial Factors
KW  - Sex Factors
KW  - Functional Assessment
KW  - Research Instruments
KW  - Funding Source
KW  - Cross Sectional Studies
KW  - Prospective Studies
KW  - Clinical Assessment Tools
KW  - Psychological Tests
KW  - Two-Tailed Test
KW  - T-Tests
KW  - Regression
KW  - Health Status
KW  - Dyspnea
KW  - Male
KW  - Female
KW  - Human
SP  - 535
EP  - 546
JO  - Research in Nursing & Health
JF  - Research in Nursing & Health
JA  - RES NURS HEALTH
VL  - 18
IS  - 6
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
AB  - OBJECTIVE: The purposes of this study were to (a) compare the functional performance profiles of men and women with COPD, (b) describe the extent to which physiologic impairment, physical symptoms, and psychosocial resources contribute in a cumulative manner to functional performance, and (c) outline the extent to which these contributions differ by gender. DESIGN: Cross-sectional data were extracted from a longitudinal study of psychophysiologic predictors of health service utilization in patients with COPD. SETTING: Pulmonary speciality clinics in the southwestern United States. POPULATION: Forty men and 45 women comprised the sample. Subjects with COPD were recruited through two pulmonary speciality clinics. Mean age of the group was 68.44 years. INTERVENTIONS: Patient perception of functional performance was measured indirectly with the Sickness Impact Profile (SIP). Physiological impairment was defined by disease severity and exercise tolerance, operationalized by FEV1 % predicted and 12-min walk distance (12-MWD). Physical symptoms were measured by postwalk dyspnea (Borg scale score) and somatic scale score on the Bronchitis-Emphysema Symptom Checklist (BESC). Psychosocial resources were measured by the Basic Need Satisfaction Inventory (BNSI) and the Modified Erikson Psychosocial Stage Inventory (MEPSI). MAIN OUTCOME MEASURE(S): Women indicated more overall, physical, and psychosocial performance difficulties, and scored higher than men on 9 of the 12 individual categories. The gender difference in home management score is noteworthy, but was not significant under the Bonferroni criterion. Somatic symptoms was a predictor of overall, physical, and psychosocial functioning for women, but had no effect for men. Need satisfaction was a significant predictor of overall, physical, and psychosocial functional performance for women and a significant predictor of psychosocial performance in men. RESULTS/CONCLUSIONS: Although the models for men and women should be considered exploratory, the findings were consistent with the speculation that there are gender differences in models of functional performance and suggest a need for further investigation.
SN  - 0160-6891
AD  - National Institutes of Health, Building 31, Room 5B10, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 7480854.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107365276&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1996-02922-016
AN  - 1996-02922-016
AU  - Safieddine, Saaid
AU  - Eybalin, Michel
T1  - Expression of mGluR1α mRNA receptor in rat and guinea pig cochlear neurons.
JF  - Neuroreport: An International Journal for the Rapid Communication of Research in Neuroscience
JO  - Neuroreport: An International Journal for the Rapid Communication of Research in Neuroscience
JA  - Neuroreport
Y1  - 1995/12//
VL  - 7
IS  - 1
SP  - 193
EP  - 196
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0959-4965
N1  - Accession Number: 1996-02922-016. PMID: 8742449 Other Journal Title: NeuroReport: For Rapid Communication of Neuroscience Research. Partial author list: First Author & Affiliation: Safieddine, Saaid; NIH/NIDCD, Bethesda, MD, US. Release Date: 19960101. Correction Date: 20090831. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cochlea; Glutamine; N-Methyl-D-Aspartate; Neural Receptors; Ribonucleic Acid. Minor Descriptor: Ganglia; Guinea Pigs; Rats; mRNA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study. Page Count: 4. Issue Publication Date: Dec, 1995. 
AB  - Examined the expression and distribution of mGluR1α mRNAs in the cochlea of the guinea pig or the rat. In situ hybridization showed that mGluR1α mRNA was expressed by type I and type II spiral ganglion neurons in the cochlea. The glial cells surrounding the type I spiral ganglion neurons lacked such expression. The hybridization signal was low compared to that reported for non-N-methyl-D-aspartate (NMDA) receptors, suggesting that mGluR1α receptors, as is the case for NMDA receptors, play a minor role in auditory transmission. The uniform expression of mGluR1α mRNAs along the cochlear spiral suggests their co-expression in spiral ganglion neurons with NMDA and non-NMDA receptors and thus functional cooperation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - expression & distribution of gGluR1 mRNA receptors in cochlear neurons & coexpression in spiral ganglion neurons with NMDA & non NMDA receptors
KW  - guinea pigs & rats
KW  - 1995
KW  - Cochlea
KW  - Glutamine
KW  - N-Methyl-D-Aspartate
KW  - Neural Receptors
KW  - Ribonucleic Acid
KW  - Ganglia
KW  - Guinea Pigs
KW  - Rats
KW  - mRNA
KW  - 1995
DO  - 10.1097/00001756-199512000-00046
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1996-02922-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17637-023
AN  - 2004-17637-023
AU  - McCrae, Robert R.
T1  - A Book in Need of a Sequel.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1995/12//
VL  - 40
IS  - 12
SP  - 1170
EP  - 1171
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17637-023. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: McCrae, Robert R.; Personality, Stress and Coping Section, Gerontology Research Center, National Institute on Aging, Baltimore, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Individual Differences; Personality Traits; Psychopathology; Social Interaction; Social Skills. Minor Descriptor: Social Influences. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Reviewed Item: Gilbert, David G. (Ed); Connolly, James J. (Ed). Personality, Social Skills, and Psychopathology: An Individual Differences Approach=New York: Plenum, 1991. 296 pp. $45.00; 1991. References Available: Y. Page Count: 2. Issue Publication Date: Dec, 1995. 
AB  - This text (see record [rid]1991-98750-000[/rid]) explores how traits and temperament can interact with social skills and interpersonal resources to influence psychopathology. The book is divided into three parts: five chapters on theoretical perspectives, four reviews of specific psychopathologies, and a token methodology chapter. Part One has the merit of offering several divergent contemporary views on the nature of personality. Part Two consists of empirical reviews concerned with depression, aggression, alcoholism, and hyperactivity, with an emphasis on social factors. The concluding chapter is intended as a non-technical introduction to the analysis of sequence in social interactions, and focuses on log-linear and lag sequential methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - personality traits
KW  - social skills
KW  - psychopathology
KW  - individual differences
KW  - social factors
KW  - social interactions
KW  - 1995
KW  - Individual Differences
KW  - Personality Traits
KW  - Psychopathology
KW  - Social Interaction
KW  - Social Skills
KW  - Social Influences
KW  - 1995
U2  - Gilbert, David G. (Ed); Connolly, James J. (Ed). (1991); Personality, Social Skills, and Psychopathology: An Individual Differences Approach; New York: Plenum, 1991. 296 pp. $45.00; 0-306-43793-7.
DO  - 10.1037/004200
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17637-023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37550-015
AN  - 2015-37550-015
AU  - Mamounas, Laura A.
AU  - Blue, Mary E.
AU  - Siuciak, Judith A.
AU  - Altar, C. Anthony
T1  - Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/12//
VL  - 15
IS  - 12
SP  - 7929
EP  - 7939
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mamounas, Laura A., Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD, US, 21224
N1  - Accession Number: 2015-37550-015. PMID: 8613731 Partial author list: First Author & Affiliation: Mamounas, Laura A.; Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, US. Release Date: 20160808. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Blue, Mary E. Major Descriptor: Chronic Pain; Neurons; Brain Derived Neurotrophic Factor. Minor Descriptor: Axons; Neurodegenerative Diseases; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 1995. Publication History: Accepted Date: Aug 4, 1995; Revised Date: Jul 25, 1995; First Submitted Date: Jan 24, 1995. Copyright Statement: Society for Neuroscience. 1995. 
AB  - A pathology of brain serotonergic (5-HT) systems has been found in psychiatric disturbances, normal aging and in neurodegenerative disorders including Alzheimer's and Parkinson's disease. Despite the clinical importance of 5-HT, little is known about the endogenous factors that have neurotrophic influences upon 5-HT neurons. The present study examined whether chronic pain parenchymal administration of the neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or NGF could prevent the severe degenerative loss of serotonergic axons normally caused by the selective 5-HT neurotoxin p-chloroamphetamine (PCA). The neurotrophins (5–12 µg/d) or the control substances (cytochrome c or PBS vehicle) were continuously infused into the rat frontoparietal cortex using an osmotic minipump. One week later, rats were subcutaneously administered PCA (10 mg/kg) or vehicle, and the 5-HT innervation was evaluated after two more weeks of neurotrophin infusion. As revealed with 5-HT immunocytochemistry, BDNF infusions into the neocortex of intact (non-PCA-lesioned) rats caused a substantial increase in 5-HT axon density in a 3 mm diameter region surrounding the cannula tip. In PCA-lesioned rats, intracortical infusions of BDNF completely prevented the severe neurotoxin-induced loss of 5-HT axons near the infusion cannula. In contrast, cortical infusions of vehicle or the control protein cytochrome c did not alter the density of serotonergic axons in intact animals, nor did control infusions prevent the loss of 5-HT axons in PCA-treated rats. NT-3 caused only a modest sparing of the 5-HT innervation in PCA-treated rats, and NGF failed to prevent the loss of 5-HT axon density. The immunocytochemical data were supported by neurochemical evaluations which showed that BDNF attenuated the PCA-induced loss of 5-HT and 5- HIAA contents and ³H-5-HT uptake near the infusion cannula. Thus, BDNF can promote the sprouting of mature, uninjured serotonergic axons and dramatically enhance the survival or sprouting of 5-HT axons normally damaged by the serotonergic neurotoxin PCA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain-derived neurotrophic factor
KW  - neurotrophin- 3
KW  - NGF
KW  - neurotrophic
KW  - 5-HT
KW  - p-chloroamphetamine
KW  - neurodegeneration
KW  - regeneration
KW  - 1995
KW  - Chronic Pain
KW  - Neurons
KW  - Brain Derived Neurotrophic Factor
KW  - Axons
KW  - Neurodegenerative Diseases
KW  - Rats
KW  - 1995
U1  - Sponsor: National Institutes of Health. Grant: NS29167. Recipients: Blue, Mary E.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37550-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-37550-035
AN  - 2015-37550-035
AU  - Gerfen, Charles R.
AU  - Keefe, Kristen A.
AU  - Gaudaia, Estelle B.
T1  - D1 and D2 dopamine receptor function in the striatum: Coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1995/12//
VL  - 15
IS  - 12
SP  - 8167
EP  - 8176
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gerfen, Charles R., LNP, NIMH, Building 36, Room 2D-10, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-37550-035. PMID: 8613751 Partial author list: First Author & Affiliation: Gerfen, Charles R.; Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20160808. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Basal Ganglia; Dopamine; Neurons; Parkinson's Disease; Striatum. Minor Descriptor: Genes; Rats. Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 1995. Publication History: Accepted Date: Aug 16, 1995; Revised Date: Aug 8, 1995; First Submitted Date: Jun 5, 1995. Copyright Statement: Society for Neuroscience. 1995. 
AB  - D1- and D2-dopamine receptor-mediated regulation of immediate early gene levels in identified populations of neurons in the striatum was examined with quantitative in situ hybridization histochemical techniques. Levels of messenger RNA (mRNA) encoding the immediate early genes zif268 and c-fos were examined in two experiments in rats with unilateral lesions of the nigrostriatal dopamine pathway. In a dose- response study, animals were treated with doses of 0.5, 1.0, and 1.5 mg/kg of the D1 agonist SKF-38393 either alone or in combination with the D2 agonist quinpirole (1 mg/kg). Levels of immediate early gene mRNAs 60 min following drug treatments showed a dose-related increase to the D1 agonist alone and a potentiation to combined D1 and D2 against treatment. In a second experiment, in animals receiving 1 mg/kg SKF-38393 either alone or in combination with 1 mg/kg quinpirole, the level of zif268 mRNA was measured with a double-labeling method in striatal neurons containing enkephalin mRNA, a marker of D2-containing neurons, and in neurons not containing enkephalin, putative D1- containing neurons. In the dopamine-depleted striatum, D1 agonist treatment alone did not affect enkephalin-positive neurons but significantly elevated zif268 mRNA levels in nearly all enkephalin- negative neurons. Combined D1 and D2 agonist treatment further increased zif268 mRNA levels in this population of enkephalin-negative neurons and decreased zif-268 mRNA levels in enkephalin-positive neurons. These data indicate that the synergistic response to combined D1- and D2-receptor stimulation is mediated by interneuronal interactions involving the activation of D1 and D2 receptors on separate populations of striatal neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - basal ganglia
KW  - striatum
KW  - dopamine receptor
KW  - synergy
KW  - gene regulation
KW  - immediate early genes
KW  - c-fos
KW  - zif266
KW  - Parkinson’s disease
KW  - 1995
KW  - Basal Ganglia
KW  - Dopamine
KW  - Neurons
KW  - Parkinson's Disease
KW  - Striatum
KW  - Genes
KW  - Rats
KW  - 1995
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-37550-035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Muehrer, Peter
T1  - Suicide and Sexual Orientation: A Critical Summary of Recent Research and Directions for Future Research.
JO  - Suicide & Life-Threatening Behavior
JF  - Suicide & Life-Threatening Behavior
Y1  - 1995/12/02/Winter1995 Supplement
VL  - 25
M3  - Article
SP  - 72
EP  - 81
SN  - 03630234
KW  - SEXUAL orientation
KW  - HUMAN sexuality
KW  - GAY people
KW  - LESBIANS -- Psychology
KW  - SUICIDAL behavior
N1  - Accession Number: 120947963; Muehrer, Peter 1; Affiliation:  1: Peter Muehrer is with the Prevention Research Branch, Division of Epidemiology and Services Research, National Institute of Mental Health.; Source Info: Winter1995 Supplement, Vol. 25, p72; Subject Term: SEXUAL orientation; Subject Term: HUMAN sexuality; Subject Term: GAY people; Subject Term: LESBIANS -- Psychology; Subject Term: SUICIDAL behavior; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/j.1943-278X.1995.tb00492.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=120947963&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107260571
T1  - Timing of sexual intercourse in relation to ovulation: effects on the probability of conception, survival of the pregnancy, and sex of the baby.
AU  - Wilcox AJ
AU  - Weinberg CR
AU  - Baird DD
Y1  - 1995/12/07/
N1  - Accession Number: 107260571. Language: English. Entry Date: 19980501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Coitus
KW  - Ovulation
KW  - Fertilization
KW  - Pregnancy Outcomes
KW  - Sex Preselection
KW  - Time Factors
KW  - Prospective Studies
KW  - Infant, Newborn
KW  - Adult
KW  - Pregnancy
KW  - Female
KW  - Human
SP  - 1517
EP  - 1521
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 333
IS  - 23
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
U2  - PMID: 7477165.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107260571&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107283524
T1  - Ribavirin as therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial.
AU  - Di Bisceglie AM
AU  - Conjeevaram HS
AU  - Fried MW
AU  - Sallie R
AU  - Park Y
AU  - Yurdaydin C
AU  - Swain M
AU  - Kleiner DE
AU  - Mahaney K
AU  - Hoofnagle JH
Y1  - 1995/12/15/
N1  - Accession Number: 107283524. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: In part by ICN Pharmaceuticals; Innogenetics. NLM UID: 0372351. 
KW  - Ribavirin -- Administration and Dosage
KW  - Hepatitis C -- Drug Therapy
KW  - Administration, Oral
KW  - Drug Administration Schedule
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Chronic Disease
KW  - Hepatitis C -- Microbiology
KW  - Placebos
KW  - Funding Source
KW  - Analysis of Variance
KW  - T-Tests
KW  - Alanine Aminotransferase
KW  - Liver Function Tests
KW  - Hepatitis C -- Pathology
KW  - Double-Blind Studies
KW  - Human
SP  - 897
EP  - 903
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 123
IS  - 12
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 0003-4819
AD  - Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 7486483.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107283524&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107394251
T1  - Steps toward gene therapy: 2. Cancer and AIDS.
AU  - Blaese RM
Y1  - 1995/12/15/
N1  - Accession Number: 107394251. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Gene Therapy
KW  - Acquired Immunodeficiency Syndrome -- Therapy
KW  - Neoplasms -- Therapy
KW  - Education, Continuing (Credit)
KW  - Genes
KW  - T Lymphocytes
KW  - DNA
KW  - RNA
SP  - 37
EP  - 71
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 30
IS  - 12
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8522626.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107394251&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Auerbach, Judith D.
AU  - Figert, Anne E.
T1  - Women's Health Research: Public Policy and Sociology.
JO  - Journal of Health & Social Behavior
JF  - Journal of Health & Social Behavior
Y1  - 1995/12/15/Dec1995 Extra Issue
VL  - 36
M3  - Article
SP  - 115
EP  - 131
SN  - 00221465
AB  - In the space of just a few years, the amount and nature of scientific research on women's health has emerged as a major policy issue being addressed at the highest levels of the federal government and in the mainstream media. This debate has engaged members of Congress, the National Institutes of Health, and other federal agencies, and medical, scientific, health, and women's organizations. Sociologists have made significant contributions to both the process by which the women's health research issue has ascended to public awareness and the content of its agenda. Many of these contributions go unrecognized and other potential contributions by medical sociologists remain unrealized. In order to advance both science and practice in women's health--by ensuring the inclusion of the sociological perspective--we encourage sociologists to participate more directly in the policy debates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WOMEN -- Health
KW  - MEDICAL policy
KW  - SOCIAL policy
KW  - PUBLIC health
KW  - SOCIOLOGISTS
N1  - Accession Number: 9510044022; Auerbach, Judith D. 1; Email Address: judith_auerbach@nih.gov Figert, Anne E. 2; Affiliation:  1: National Institutes of Health  2: Loyola University of Chicago; Source Info: Dec1995 Extra Issue, Vol. 36, p115; Subject Term: WOMEN -- Health; Subject Term: MEDICAL policy; Subject Term: SOCIAL policy; Subject Term: PUBLIC health; Subject Term: SOCIOLOGISTS; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105854837
T1  - Meeting highlights: a reappraisal of research results for the local treatment of early stage breast cancer.
AU  - Abrams JS
AU  - Phillips PH
AU  - Friedman MA
Y1  - 1995/12/20/
N1  - Accession Number: 105854837. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Therapy
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Clinical Trials
KW  - Combined Modality Therapy
KW  - Lumpectomy
KW  - Mastectomy
KW  - Middle Age
KW  - Neoplasms, Radiation-Induced
KW  - Radiotherapy -- Adverse Effects
KW  - Risk Factors
KW  - Survival Analysis
KW  - Time Factors
KW  - Human
SP  - 1837
EP  - 1845
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Treatment, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 7494227.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854837&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854838
T1  - Geographic variation in mortality from breast cancer among white women in the United States.
AU  - Sturgeon SR
AU  - Schairer C
AU  - Gail M
AU  - McAdams M
AU  - Brinton LA
AU  - Hoover RN
Y1  - 1995/12/20/
N1  - Accession Number: 105854838. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Mortality
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Education
KW  - Female
KW  - Geographic Factors
KW  - Middle Age
KW  - Parity
KW  - Relative Risk
KW  - Risk Factors
KW  - Socioeconomic Factors
KW  - United States
KW  - Whites
KW  - Human
SP  - 1846
EP  - 1853
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 7494228.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854838&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854840
T1  - Induction of T-cell immunity against Ras oncoproteins by soluble protein or Ras-expressing Escherichia coli.
AU  - Fenton RG
AU  - Keller CJ
AU  - Hanna N
AU  - Taub DD
Y1  - 1995/12/20/
N1  - Accession Number: 105854840. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Proteins -- Immunology
KW  - T Lymphocytes -- Immunology
KW  - Animals
KW  - Cytokines -- Metabolism
KW  - Escherichia Coli
KW  - Immunity
KW  - Immunity, Cellular
KW  - Immunization
KW  - Immunologic Techniques
KW  - Mice
KW  - Mutation
KW  - Neoplasms -- Prevention and Control
KW  - Peptides -- Immunology
KW  - Recombinant Proteins
SP  - 1853
EP  - 1861
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 87
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Clinical Sciences, National Cancer Institute, National Cancer Institute-Frederick Cancer Research and Development Center (NCI-FCRDC), MD 21702, USA.
U2  - PMID: 7494229.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854840&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - CUNNION, ROBERT E.
AU  - PARRILLO, JOSEPH E.
AU  - MAISCH, BERNHARD
AU  - CAMERINI, FULVIO
AU  - SCHULTHEISS, HEINZ-PETER
AU  - COOPER, JR., LESLIE T.
AU  - SHABETAI, RALPH
AU  - MASON, JAY W.
AU  - O'CONNELL, JOHN B.
AU  - MCMANUS, BRUCE M.
T1  - IMMUNOSUPPRESSIVE THERAPY FOR MYOCARDITIS.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1995/12/21/
VL  - 333
IS  - 25
M3  - Article
SP  - 1713
EP  - 1714
SN  - 00284793
N1  - Accession Number: 88378134; CUNNION, ROBERT E. 1 PARRILLO, JOSEPH E. 2 MAISCH, BERNHARD 3 CAMERINI, FULVIO 4 SCHULTHEISS, HEINZ-PETER 5 COOPER, JR., LESLIE T. 6 SHABETAI, RALPH 6 MASON, JAY W. 7 O'CONNELL, JOHN B. 8 MCMANUS, BRUCE M. 9; Affiliation:  1: National Institutes of Health, Bethesda, MD 20892  2: Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612  3: Philipps University, D-35033 Marburg, Germany  4: Ospedale Riuniti, 1-34100 Trieste, Italy  5: Benjamin Franklin University D-12200 Berlin, Germany  6: University of California, San Diego, Medical Center, San Diego, CA 92103-8411  7: University of Utah Medical Center, Salt Lake City, UT 84132  8: University of Mississippi Jackson, MS 39216  9: University of British Columbia Vancouver, BC V6T 2B5, Canada; Source Info: 12/21/95, Vol. 333 Issue 25, p1713; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - Gen
ID  - 9999-52027-000
AN  - 9999-52027-000
AU  - Caraceni, Augusto
AU  - Mendoza, Tito R.
AU  - Mencaglia, Emanuela
AU  - Baratella, Claudio
AU  - Edwards, Katherine
AU  - Forjaz, Maria Joao
AU  - Martini, Cinzia
AU  - Serlin, Ronald C.
AU  - de Conno, Franco
AU  - Cleeland, Charles S.
T1  - Brief Pain Inventory--Italian Version
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1996///
AD  - Caraceni, Augusto, National Cancer Institute of Milan, Pain Therapy and Palliative Care Division, via Venezian 1, 20133, Milan, Italy
AV  - Commercial: No; Permissions: Contact Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-52027-000. Other Names: Breve Questionario Per La Valutazione Del Dolore. Acronyms: BPI; BVQD. Partial author list: First Author & Affiliation: Caraceni, Augusto; National Cancer Institute of Milan, Pain Therapy and Palliative Care Division, Milan, Italy. Release Date: 20161114. Instrument Type: Inventory/Questionnaire. Test Format: The BPI consists of 10 items and utilizes 0-10 scales for subject ratings (0 = no pain and 10 = pain as bad as you can imagine).. Language: Italian. Constructs: Pain Intensity; Pain Interference; Classification: Physical Health/Illness Related Assessment (7300). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Other Versions: 9999-16304-000, Brief Pain Inventory—Chinese, Revision. 
AB  - Purpose: The purpose of the Brief Pain Inventory--Italian Version is to assess pain intensity and pain interference with daily functions.
AB  - Description: The Brief Pain Inventory--Italian Version (BPI; Caraceni et al., 1996), was translated from the original Brief Pain Inventory (BPI; Cleeland et al., 1994), designed to assess pain intensity and pain interference with daily functions. The BPI measures both pain intensity and interference of pain with the patient's life. It also queries the patient about pain relief, pain quality, and patient perception of the cause of pain. In the BPI 0-10 scales are used for subject ratings. These scales have demonstrated their utility across cultures (Cleeland, 1990), and are easy to understand. The BPI takes only about 15 minutes to complete, and results are comparable whether self-administered or administered by an interviewer. The Italian version of the BPI, 'Breve Questionario per la Valutazione del Dolore' (BQVD), was translated by Paolo Marchettini, and it was pilot tested in two Italian national cancer centers (Genua, Milan). The sample included 110 patients with cancer pain (aged 20-77 years). Confirmatory factor analysis was utilized to ascertain construct validity, producing a 2-factor solution: interference (6 items) and severity (4 items). Measures of interference and of intensity were calculated a priori from the Therapy Impact Questionnaire (TIQ; Tamburini et al., 1992) results and were used in correlated correlations. Results indicated the measure was both valid and reliable. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Brief Pain Inventory--Italian Version
KW  - Cancer Pain
KW  - Cancer Patients
KW  - Construct Validity
KW  - Daily Functions
KW  - Factor Analysis
KW  - Factor Structure
KW  - Interference Subscale
KW  - Severity Subscale
KW  - Test Development
KW  - Test Reliability
KW  - Test Translation
U5  - Brief Pain Inventory--Italian Version (BPI, BVQD) [Test Development]A validation study of an Italian version of the Brief Pain Inventory (Breve Questionario Per La Valutazione Del Dolore). (AN: 1996-05227-005 from PsycINFO) Caraceni, Augusto; Mendoza, Tito R.; Mencaglia, Emanuela; Baratella, Claudio; Edwards, Katherine; Forjaz, Maria Joao; Martini, Cinzia; Serlin, Ronald C.; de Conno, Franco; Cleeland, Charles S.; Apr, 1996. Source: Pain. 65(1), Elsevier Science, Netherlands; Apr, 1996; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Inpatient; Location: Italy; Sample: Patients with Cancer Pain, Aged 21-77 Years Keywords: Brief Pain Inventory--Italian Version; Cancer Pain; Cancer Patients; Construct Validity; Daily Functions; Factor Analysis; Factor Structure; Interference Subscale; Severity Subscale; Test Development; Test Reliability; Test Translation; Subjects: Activities of Daily Living; Factor Analysis; Factor Structure; Foreign Language Translation; Neoplasms; Pain; Pain Management; Pain Measurement; Patients; Physical Health Assessment; Severity (Disorders); Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t52027-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-52027-000&site=ehost-live&scope=site
UR  - caraceni@micronet.it
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
ID  - 107319499
T1  - Gene therapy for cystic fibrosis.
AU  - Rosenfeld MA
AU  - Collins FS
Y1  - 1996/01//1996 Jan
N1  - Accession Number: 107319499. Language: English. Entry Date: 19970401. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0231335. 
KW  - Cystic Fibrosis -- Therapy
KW  - Gene Therapy
KW  - Chromosomes
KW  - Clinical Trials
KW  - Cystic Fibrosis -- Familial and Genetic
KW  - Cystic Fibrosis -- Physiopathology
KW  - Genetics
KW  - Genetic Techniques
KW  - DNA
SP  - 241
EP  - 252
JO  - CHEST
JF  - CHEST
JA  - CHEST
VL  - 109
IS  - 1
CY  - Glenview, Illinois
PB  - American College of Chest Physicians
SN  - 0012-3692
AD  - Laboratory of Gene Transfer, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 8549191.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107319499&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sung, Cynthia
T1  - On Biomedical Engineering.
JO  - Chinese American Forum
JF  - Chinese American Forum
Y1  - 1996/01//
VL  - 11
IS  - 3
M3  - Article
SP  - 12
EP  - 12
PB  - Chinese American Forum Inc.
SN  - 08954690
N1  - Accession Number: 21133807; Sung, Cynthia 1; Affiliation:  1: Biomedical Engineer, National Institutes of Health; Source Info: Jan2006, Vol. 11 Issue 3, p12; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107939130
T1  - NIDDM: Epidemiology and Scope of the Problem.
AU  - Harris, Maureen I.
Y1  - 1996/01//
N1  - Accession Number: 107939130. Language: English. Entry Date: 20131121. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8913432. 
KW  - Diabetes Mellitus, Type 2 -- Epidemiology
KW  - Diabetes Mellitus, Type 2 -- Complications
KW  - Diabetes Mellitus, Type 2 -- Mortality
KW  - Diabetes Mellitus, Type 2 -- Economics
SP  - 26
EP  - 29
JO  - Diabetes Spectrum
JF  - Diabetes Spectrum
JA  - DIABETES SPECTRUM
VL  - 9
IS  - 1
CY  - Alexandria, Virginia
PB  - American Diabetes Association
SN  - 1040-9165
AD  - Director, National Diabetes Data Group, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107939130&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Mosher, William D.
AU  - Bachrach, Christine A.
T1  - Understanding U.S. Fertility: Continuity And Change in the National Survey Of Family Growth, 1988-1995.
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
Y1  - 1996/01//Jan/Feb96
VL  - 28
IS  - 1
M3  - Article
SP  - 4
EP  - 12
PB  - Guttmacher Institute, Inc.
SN  - 00147354
AB  - The article presents information on a study conducted by the National Survey of Family Growth (NSFG), on the fertility and health of American women. Discussion in the article uses as its conceptual framework, the proximate determinants of fertility, which are collected in the NSFG. These intermediate variables of fertility include intercourse variables, conception variables, and gestation variables. It has become more difficult for young Americans to marry and start families. There are large racial differences in the proportions who never marry. The likelihood of contraceptive method use at first intercourse varies widely by demographic characteristics. Four major trends in current contraceptive use were apparent from 1982 through 1990. The data show that when rates of fetal loss are expressed as fetal losses divided by live births plus fetal losses, about one in six pregnancies ends in a miscarriage or stillbirth. Low education, low income, older age and black race increase the probability of an unwanted birth. A correlate of fertility is religious affiliation. Contraceptive use is closely tied to use of the health care system. Behavior that raises the risk of STD infection increased among teenagers.
KW  - WOMEN -- United States
KW  - WOMEN -- Health
KW  - HUMAN fertility
KW  - BIRTH control
KW  - SEXUAL intercourse
KW  - UNITED States
N1  - Accession Number: 9603200739; Mosher, William D. 1 Bachrach, Christine A. 2; Affiliation:  1: Chief of the Family growth Survey Branch, National Center for Health Statistics (NCHS), Hyattsville.  2: Chief of the Demographic and Behavioral Sciences Branch, National Institute of Child Health and Human Development(NICHD), Bethesda.; Source Info: Jan/Feb96, Vol. 28 Issue 1, p4; Subject Term: WOMEN -- United States; Subject Term: WOMEN -- Health; Subject Term: HUMAN fertility; Subject Term: BIRTH control; Subject Term: SEXUAL intercourse; Subject Term: UNITED States; NAICS/Industry Codes: 621410 Family Planning Centers; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 10039
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - CHAPIN, ROBERT E.
AU  - STEVENS, JAMES T.
AU  - HUGHES, CLAUDE L.
AU  - KELCE, WILLIAM R.
AU  - HESS, REX A.
AU  - DASTON, GEORGE P.
T1  - Endocrine Modulation of Reproduction1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/01//
VL  - 29
IS  - 1
M3  - Article
SP  - 1
EP  - 17
PB  - Oxford University Press / USA
SN  - 02720590
AB  - The ability of foreign compounds to affect the functioning of various endocrine systems is currently thought responsible for a wide variety of effects. The presentations in this Symposium reviewed the evidence for and against the involvement of endocrine systems in several different aspects of reproduction. The mechanism behind the ability of a triazine herbicide to cause enhanced appearance of mammary tumors in one strain of female rats is reviewed by Stevens. The data suggest that enhanced aging, not direct mammary modulation, is responsible. Dietary phytoestrogens, the mediators of their actions, their effects in various biological systems, and the relationships between phytoestrogen producers and consumers are all provocatively and succinctly reviewed by Hughes. Kelce presents the strategy used to dissect the mode and mechanisms of action of a fungicide that opened a new awareness in reproductive toxicology: the possibility of xenobiotics being antiandrogens. Finally, to heighten our understanding of the interplay among hormonal systems in vivo, Hess reviews the data that show that androgens are not the only hormones important in the development of the male reproductive system: the pituitary is shown to play a critical role at specific stages of development. The breadth of these presentations, and the implications of their findings, should make us pause and realize how much there is still to discover about the interaction between the reproductive system and anthropogenic compounds. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Hormones
KW  - Alkylating agents
KW  - Endocrine system
KW  - Rats as laboratory animals
KW  - Triazines
KW  - Endocrine glands
N1  - Accession Number: 82425501; CHAPIN, ROBERT E. 1; STEVENS, JAMES T. 2; HUGHES, CLAUDE L. 3; KELCE, WILLIAM R. 4; HESS, REX A. 5; DASTON, GEORGE P. 6; Affiliations: 1: Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; 2: † Department of Toxicology, Crop Protection Division Ciba-Geigy, Greensboro, North Carolina; 3: ‡ Comparative Medicine Clinical Research Center, Department of Comparative Medicine and Obstetrics & Gynecology, The Bowman Gray School of Medicine, Wake Forest University Winston Salem, North Carolina 27109; 4: § Reproductive Toxicology Branch, Developmental Toxicology Division, Health Effects Research Lab, U.S. EPA Research Triangle Park, North Carolina 27711; 5: Department of Veterinary Biosciences, University of Illinois Urbana, Illinois 61801; 6: ‖ The Procter and Gamble Co. Cincinnati, Ohio; Issue Info: 1996, Vol. 29 Issue 1, p1; Thesaurus Term: Hormones; Thesaurus Term: Alkylating agents; Subject Term: Endocrine system; Subject Term: Rats as laboratory animals; Subject Term: Triazines; Subject Term: Endocrine glands; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GRIFFIN, ROBERT J.
AU  - DUDLEY, CHRIS N.
AU  - CUNNINGHAM, MICHAEL L.
T1  - Biochemical Effects of the Mouse Hepatocarcinogen Oxazepam: Similarities to Phenobarbital.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/01//
VL  - 29
IS  - 1
M3  - Article
SP  - 147
EP  - 154
PB  - Oxford University Press / USA
SN  - 02720590
AB  - The National Toxicology Program (NTP) recently determined that the commonly prescribed sedative hypnotic agent oxazepam is a mouse liver carcinogen. Many other benzodiazepines are metabolized to oxazepam resulting in further human exposure to this drug. This has resulted in considerable interest in the mechanism of oxazepam-mediated mouse liver carcinogenesis for use in human risk assessment. Several directions for mechanistic research were examined in this study. B6C3F1 mice were treated with oxazepam-dosed feed at 125 (noncarcinogenic) and 2500 ppm (carcinogenic) for 3, 7, 10, and 21 days. Cell proliferation in liver, cytochrome P450 induction, free radical formation, GSH depletion, and levels of circulating thyroid-stimulating hormone (TSH) were analyzed at these time points. Increased levels of hepatic cell proliferation were observed by 7 days at 125 ppm and by 10 days at 2500 ppm. Microsomal enzyme induction also occurred and was associated with elevated plasma TSH levels. Hepatic GSH levels were slightly depressed but there was no evidence of increased oxidative stress. A similar pattern of biochemical events has been observed to occur during dosed feed treatment with phenobarbital. These results suggest that oxazepam and phenobarbital may induce carcinogenesis by similar mechanisms in mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogens
KW  - Animal experimentation
KW  - Oxazepam (Drug)
KW  - Benzodiazepines
KW  - Liver diseases
N1  - Accession Number: 82425507; GRIFFIN, ROBERT J. 1; DUDLEY, CHRIS N. 1; CUNNINGHAM, MICHAEL L. 1; Affiliations: 1: Chemistry Branch, National Institute of Environmental Health Sciences Research Triangle Park. North Carolina 27709; Issue Info: 1996, Vol. 29 Issue 1, p147; Thesaurus Term: Carcinogens; Thesaurus Term: Animal experimentation; Subject Term: Oxazepam (Drug); Subject Term: Benzodiazepines; Subject Term: Liver diseases; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Hampel, H.
AU  - Berger, C.
AU  - Möller, H.-J.
AU  - Müller-Spahn, F.
T1  - Letters.
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1996/01//Jan/Feb96
VL  - 11
IS  - 1
M3  - Letter
SP  - 69
EP  - 70
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - Presents a letter to the editor on oral anticoagulation under the influence of reversible and irreversible monoamine oxidase inhibitors.
KW  - LETTERS to the editor
KW  - MONOAMINE oxidase inhibitors
N1  - Accession Number: 14159243; Hampel, H. 1 Berger, C. 2 Möller, H.-J. 2 Müller-Spahn, F. 3; Affiliation:  1: National Institutes of Health, National Institute on Aging, Bethesda, MD, USA.  2: Department of Psychiatry, University of Munich, D-80336 Munich, Germany.  3: Department of Psychiatry, University of Basle, CH-4025 Basle, Switzerland.; Source Info: Jan/Feb96, Vol. 11 Issue 1, p69; Subject Term: LETTERS to the editor; Subject Term: MONOAMINE oxidase inhibitors; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Duchmann, R.
AU  - Jaffe, J.
AU  - Ehrhardt, R.
AU  - Alling, D. W.
AU  - Strober, W.
T1  - Differential usage of T-cell receptor Vβ gene families by CD4+ and CD8+ T cells in patients with CD8hi common variable immunodeficiency: evidence of a post-thymic effect.
JO  - Immunology
JF  - Immunology
Y1  - 1996/01//
VL  - 87
IS  - 1
M3  - Article
SP  - 99
EP  - 107
PB  - Wiley-Blackwell
SN  - 00192805
AB  - In this study, we report that differences between T-cell receptor (TCR) Vβ gene family usage in CD4+ and CD8+ T cells are significantly greater in a subgroup of patients with common variable immanodeficiency (CVI) and high levels of activated CD8+ T cells (CD8hi CVI) than in controls (P < 0·001). In CD8hi CVI patients, such differences were also significantly greater for Vβ12 than for other Vβ families. As the causes of the differential usage of Vβ gene families by CD4+ and CD8+ T cells are under investigation, it was interesting that the combined differences between Vβ gene family usage in the CD4+ and CD8+ T-cell subpopulations as a whole were significantly lower than the combined differences between individual Vβ gene family usage in either CD4+ or CD8+ T-cell subpopulations (P < 0·001 in both control and CD8hi CVI patients). Further, the pattern of Vβ gene family usage in CD4+ T cells was remarkably similar to that in CD8+ T cells in both groups. These data strongly suggest that differences in Vβ gene family usage arising from co-selection by major histocompatibility complex (MHC) class I versus MHC class II restriction elements do not fundamentally distort ‘basic’ Vβ gene family usage patterns. They also support the concept that differences in CD4+ and CD8+ T-cell Vβ gene family usage, which were increased in CD8hi CVI, can arise from high-affinity interactions between disease-associated antigens or superantigens and T cells in the post-thymic T-cell compartment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T-cell receptor genes
KW  - GENES
KW  - T cell receptors
KW  - T cells
KW  - IMMUNODEFICIENCY
KW  - IMMUNITY
N1  - Accession Number: 14071116; Duchmann, R. 1 Jaffe, J. 2 Ehrhardt, R. 2 Alling, D. W. 3 Strober, W. 2; Affiliation:  1: First Department of Internal Medicine, University of Mainz, Germany  2: Mucosal Immunity Section, Laboratory of Clinical Investigation  3: Office of the Director for Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: Jan1996, Vol. 87 Issue 1, p99; Subject Term: T-cell receptor genes; Subject Term: GENES; Subject Term: T cell receptors; Subject Term: T cells; Subject Term: IMMUNODEFICIENCY; Subject Term: IMMUNITY; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107329912
T1  - Dementia Mood Assessment Scale.
AU  - Sunderland T
AU  - Minichiello M
AU  - Sunderland, T
AU  - Minichiello, M
Y1  - 1996/01//1/ 1/1996
N1  - Accession Number: 107329912. Language: English. Entry Date: 19981101. Revision Date: 20161117. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007918. 
KW  - Clinical Assessment Tools
KW  - Depression -- Diagnosis
KW  - Dementia -- Complications
KW  - Aged
SP  - 329
EP  - 331
JO  - International Psychogeriatrics
JF  - International Psychogeriatrics
JA  - INT PSYCHOGERIATR
PB  - Cambridge University Press
SN  - 1041-6102
AD  - Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
AD  - Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland
U2  - PMID: 9154584.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107391310
T1  - Strengthening parent-teenager relationships: guidelines for PAs.
AU  - Perez-Bouchard L
AU  - Nitz K
AU  - Felice ME
Y1  - 1996/01//
N1  - Accession Number: 107391310. Language: English. Entry Date: 19961201. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9513102. 
KW  - Parent-Child Relations
KW  - Adolescent Development
KW  - Physician Assistants
KW  - Interpersonal Relations
KW  - Communication
KW  - Sexuality
KW  - Parenting
KW  - Self Concept
KW  - Child
KW  - Adolescence
SP  - 57
EP  - 66
JO  - JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.)
JF  - JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.)
JA  - JAAPA J AM ACAD PHYSICIAN ASSIST
VL  - 9
IS  - 1
CY  - New York, New York
PB  - Haymarket Media, Inc.
AB  - Adolescence precipitates physical and psychosocial changes that many disrupt the bond between adolescents and their parents. Here are strategies for PAs to help strengthen parent-teenager relationshps and a review of the growth tasks that affect the parent-child relationship.
SN  - 1547-1896
AD  - National Cancer Institute, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107323735
T1  - Changes in spinal recurrent inhibition in patients during the immediate post-stroke period.
AU  - Simon ES
Y1  - 1996/01//
N1  - Accession Number: 107323735. Language: English. Entry Date: 19970601. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8804109. 
KW  - Stroke -- Complications
KW  - Muscle Spasticity
KW  - Muscle Strength -- Evaluation
KW  - Electrophysiology
KW  - Motor Neurons
KW  - Nervous System -- Physiopathology
KW  - Repeated Measures
KW  - Time Factors
KW  - Neurologic Examination
KW  - Nerve Fibers
KW  - Clinical Research
KW  - Data Analysis, Statistical
KW  - Convenience Sample
KW  - Neural Conduction
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 35
EP  - 42
JO  - Journal of Neurologic Rehabilitation
JF  - Journal of Neurologic Rehabilitation
JA  - J NEUROL REHABIL
VL  - 10
IS  - 1
PB  - American Society of Neurorehabilitation
AB  - Functional abnormalities of segmental spinal cord neurons likely contribute to the pathogenesis of spasticity following stroke. Identification of dysfunctional circuit elements responsible for spasticity could lead to rational pharmacotherapy for this set of motor disorders. The purpose of this study was to clarify the role of the spinal recurrent inhibitory pathway in the development of spasticity: to seek clinico-electrophysiological correlations between objective signs signifying increased spinal excitability and the level of recurrent inhibition acting on spinal segmental circuitry. The study population was limited to patients with recent motor strokes, and testing was done longitudinally during the development of spasticity. Recurrent inhibition was approximated by the conditioned H' response of Bussel and Pierrot-Desseiligny. Ratios of amplitudes of soleus H-reflex to conditioned H' responses were computed for patients who were tested at least twice during the early post-stroke period. On initial testing, there were absent H' responses in the affected limbs of the patients, compared to healthy controls, indicating a supranormal level of activity of Renshaw cells. In two patients, serial testing revealed a progressive and sustained increase of the H' response amplitude in the affected limb coincident with development of hyperreflexia. Therefore, in at least some patients, decreased recurrent inhibition paralleling clinical detection of spasticity may indicate a pathogenetic of spasticity. If this trend is supported in larger studies, these data provide a rationale for specific antispastic pharmacological therapy targeted to the Renshaw cell early in the post-stroke period. This preliminary study demonstrates the importance of a longitudinal testing design in studies seeking to understand pathophysiological mechanisms of spasticity.
SN  - 0888-4390
AD  - Laboratory of Neural Control, NINDS, National Institutes of Health, Bldg 49, Room 3A50, 9000 Rockville Pike, Bethesda, MD 20892, email: esimon@Box-e.nih.gov
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107366868
T1  - Prognostic value of quality of life scores in terminal cancer patients.
AU  - Tamburini M
AU  - Brunelli C
AU  - Rosso S
AU  - Ventafridda V
Y1  - 1996/01//1996 Jan
N1  - Accession Number: 107366868. Language: English. Entry Date: 19960401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Therapy Impact Questionnaire (TIQ). Grant Information: Supported by the Italian National Research Council. NLM UID: 8605836. 
KW  - Terminally Ill Patients
KW  - Cancer Patients
KW  - Prognosis
KW  - Quality of Life -- Evaluation
KW  - Cross Sectional Studies
KW  - Questionnaires
KW  - Instrument Validation
KW  - Reliability and Validity
KW  - Symptoms
KW  - Functional Status
KW  - Survival Analysis
KW  - Fisher's Exact Test
KW  - T-Tests
KW  - Kaplan-Meier Estimator
KW  - Data Analysis, Statistical
KW  - Scales
KW  - Funding Source
KW  - Palliative Care
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 32
EP  - 41
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 11
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
AB  - A multicenter cross-sectional study of 115 terminal cancer patients in eight home-care units assessed the prognostic value of quality of life scores, as measured by the Therapy Impact Questionnaire (TIQ). The analysis of the questionnaires completed by 100 patients revealed an association between survival and many of the scales: fatigue, gastrointestinal symptoms, global health status, functional impairment, emotional status, and cognitive status. This association was also observed for some specific physical symptoms, such as confusion, weakness, and loss of appetite, and the overall number of symptoms reported by the patient. Adjusting for some possible confounding factors, only confusion (among the physical symptoms), cognitive status, and global health status (among TIQ primary scales) showed independent prognostic value. As regards the latter two scales, median survival time was distributed differently for patients with no impairment of either (137 days), with impairment of one scale (50 days) and with impairment of both scales (17 days). The judgment expressed by the patient about subjective perception of general malaise and cognitive difficulties can give the clinician important prognostic information. (c) U.S. Cancer Pain Relief Committee, 1996. Reprinted by permission of Elsevier Science Publishing Co., Inc.
SN  - 0885-3924
AD  - Division of Psychological Research, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy
U2  - PMID: 8815148.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - CHAP
ID  - 1996-97640-011
AN  - 1996-97640-011
AU  - Maccoby, Eleanor E.
AU  - Kahn, Alfred J.
AU  - Everett, Barbara A.
ED  - Lorion, Raymond P.
ED  - Iscoe, Ira
ED  - DeLeon, Patrick H.
ED  - VandenBos, Gary R.
ED  - Lorion, Raymond P., (Ed)
ED  - Iscoe, Ira, (Ed)
ED  - DeLeon, Patrick H., (Ed)
ED  - VandenBos, Gary R., (Ed)
T1  - The role of psychological research in the formation of policies affecting children.
T2  - Psychology and public policy:  Balancing public service and professional need.
Y1  - 1996///
SP  - 183
EP  - 191
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-347-X
N1  - Accession Number: 1996-97640-011. Partial author list: First Author & Affiliation: Maccoby, Eleanor E.; Stanford U, Dept of Psychology, Stanford, CA, US. Release Date: 19961001. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. ISBN: 1-55798-347-X, Paperback. Language: English. Major Descriptor: Experimentation; Government Policy Making; Psychology. Classification: Political Processes & Political Issues (2960). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 9. 
AB  - This reprinted article originally appeared in American Psychologist, Vol 38(1) Jan, 1983, pp. 80-84. (The following abstract of the original article appeared in record [rid]1983-30188-001[/rid].) Discusses factors that determine whether, and how, psychological research will have an impact on public policies regarding children. Factors discussed include (a) consistencies and inconsistencies in research findings, especially cases in which early results are greatly modified, or even reversed, by later ones; (b) cases in which documentation of a problem is not accompanied by information on the costs and benefits of possible remedial measures; (c) in evaluation research, failure to monitor the implementation as well as the expected outcomes of interventions; and (d) disjunctions in timing between the appearance of a research finding and congressional schedules, executive decision processes, and the agendas of interest groups. The importance of the political climate is stressed, as well as the need for researchers to know the right times and places for introducing their information to the policymaking process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - impact of psychological research
KW  - public policies affecting children
KW  - 1996
KW  - Experimentation
KW  - Government Policy Making
KW  - Psychology
KW  - 1996
DO  - 10.1037/10194-011
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1996-97640-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 1996-97640-021
AN  - 1996-97640-021
AU  - Leshner, Alan I.
ED  - Lorion, Raymond P.
ED  - Iscoe, Ira
ED  - DeLeon, Patrick H.
ED  - VandenBos, Gary R.
ED  - Lorion, Raymond P., (Ed)
ED  - Iscoe, Ira, (Ed)
ED  - DeLeon, Patrick H., (Ed)
ED  - VandenBos, Gary R., (Ed)
T1  - Psychology research and NIMH: Opportunities and challenges.
T2  - Psychology and public policy:  Balancing public service and professional need.
Y1  - 1996///
SP  - 355
EP  - 359
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-347-X
N1  - Accession Number: 1996-97640-021. Partial author list: First Author & Affiliation: Leshner, Alan I.; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 19961001. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. ISBN: 1-55798-347-X, Paperback. Language: English. Major Descriptor: Experimentation; Psychology. Classification: General Psychology (2100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. 
AB  - This reprinted article originally appeared in American Psychologist, Vol 46(9) Sep, 1991, pp. 977-979. (The following abstract of the original article appeared in record [rid]1992-03782-001[/rid].) As an essential contributor to the scientific understanding of mental health and illness, psychology continues to be the leading discipline receiving National Institute of Mental Health (NIMH) research support. Future behavioral science research initiatives at NIMH are likely to emphasize cognitive science, behavioral genetics, behavioral patterns and physiological systems, and personality, motivation, emotion, and interpersonal processes. Although prognostication is particularly risky in times of transition such as the present, advocacy efforts focused on mental-illness-related research are most likely to help the NIMH and the field if they avoid polarization and factionalization by providing equal encouragement for studies of biological aspects, of behavioral aspects, and of their interaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - future trends & issues in behavioral science research initiatives at National Institute of Mental Health
KW  - 1996
KW  - Experimentation
KW  - Psychology
KW  - 1996
DO  - 10.1037/10194-021
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 1996-97823-027
AN  - 1996-97823-027
AU  - Hibbs, Euthymia D.
AU  - Jensen, Peter S.
ED  - Hibbs, Euthymia D.
ED  - Jensen, Peter S.
ED  - Hibbs, Euthymia D., (Ed)
ED  - Jensen, Peter S., (Ed)
T1  - Analyzing the research: What this book is about.
T2  - Psychosocial treatments for child and adolescent disorders:  Empirically based strategies for clinical practice.
Y1  - 1996///
SP  - 3
EP  - 8
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-330-5
N1  - Accession Number: 1996-97823-027. Partial author list: First Author & Affiliation: Hibbs, Euthymia D.; National Institute of Mental Health (NIMH), Division of Clinical and Treatment Research, Child and Adolescent Disorders Research Branch, US. Release Date: 19961101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-330-5, Hardcover. Language: English. Major Descriptor: Adolescent Psychotherapy; Child Psychotherapy; Experimentation; Psychosocial Factors. Minor Descriptor: Treatment Effectiveness Evaluation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Page Count: 6. 
AB  - It is estimated that between 17 and 22% of children aged 6-18 yrs exhibit some form of behavioral, emotional, or developmental disorder. Most such youth who seek help receive some form of psychosocial intervention. Although the need has been great, research on the psychosocial treatment of children and adolescents has not received as much attention as that of adults. It is estimated that more than 200 treatment modalities are actually practiced with this population, and research has examined only a few. Therefore, a situation exists in which many treatments are practiced on children without scientific verification of their efficacy. This volume was written for several audiences: practitioners, treatment researchers, students, health care administrators, and others who make decisions about the services to be provided for our nation's youth. The goals are to disseminate the emerging findings on child and adolescent treatment research to investigators and practitioners, to demystify the research milieu, to generate increased linkages among specialists working in different areas of the field, and to kindle the motivation of students who would consider venturing into the new world of psychosocial treatment research and empirically based practice for child and adolescent disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - psychosocial treatment research
KW  - psychosocial intervention
KW  - child & adolescent disorders
KW  - 1996
KW  - Adolescent Psychotherapy
KW  - Child Psychotherapy
KW  - Experimentation
KW  - Psychosocial Factors
KW  - Treatment Effectiveness Evaluation
KW  - 1996
DO  - 10.1037/10196-027
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1996-97823-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 1996-97823-039
AN  - 1996-97823-039
AU  - Hibbs, Euthymia D.
AU  - Jensen, Peter S.
AU  - Pilkonis, Paul A.
ED  - Hibbs, Euthymia D.
ED  - Jensen, Peter S.
ED  - Hibbs, Euthymia D., (Ed)
ED  - Jensen, Peter S., (Ed)
T1  - From ivory tower to clinical practice: Future directions for child and adolescent psychotherapy research.
T2  - Psychosocial treatments for child and adolescent disorders:  Empirically based strategies for clinical practice.
Y1  - 1996///
SP  - 701
EP  - 711
CY  - Washington, DC, US
PB  - American Psychological Association
SN  - 1-55798-330-5
N1  - Accession Number: 1996-97823-039. Partial author list: First Author & Affiliation: Hibbs, Euthymia D.; National Institute of Mental Health (NIMH), Division of Clinical and Treatment Research, Child and Adolescent Disorders Research Branch, US. Release Date: 19961101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-330-5, Hardcover. Language: English. Major Descriptor: Adolescent Psychotherapy; Child Psychotherapy; Clinical Practice; Experimentation; Future. Minor Descriptor: Psychotherapeutic Techniques; Treatment Effectiveness Evaluation. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 11. 
AB  - Suggests that researchers, clinical practitioners, and family partners must work closely together to bridge the gaps between treatment research and treatments in clinical settings, and between traditional treatment strategies and family-centered treatment approaches. Such efforts will enable us not to simply translate findings into practice but also to determine the actual mental health needs and most effective treatments for children and families in real-world settings. Bridging these gaps will require the development of new assessment tools that can be used more readily in day-to-day clinical practice and are palatable and feasible in such settings, and the development of sensible clinical algorithms and decision trees that are testable and comparable with other alternatives. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child psychotherapy
KW  - adolescent psychotherapy
KW  - research
KW  - clinical practice
KW  - future trends
KW  - 1996
KW  - Adolescent Psychotherapy
KW  - Child Psychotherapy
KW  - Clinical Practice
KW  - Experimentation
KW  - Future
KW  - Psychotherapeutic Techniques
KW  - Treatment Effectiveness Evaluation
KW  - 1996
DO  - 10.1037/10196-039
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1996-97823-039&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107314384
T1  - Use of mouthguards and headgear in organized sports by school-aged children.
AU  - Nowjack-Raymer RE
AU  - Gift HC
Y1  - 1996/01//Jan/Feb96
N1  - Accession Number: 107314384. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Instrumentation: 1991 National Health Interview Survey (NHIS) of Child Health. NLM UID: 9716844. 
KW  - Head Protective Devices -- Utilization -- In Infancy and Childhood
KW  - Head Protective Devices -- Utilization -- In Adolescence
KW  - Athletic Injuries -- Prevention and Control
KW  - United States
KW  - Child Health
KW  - Secondary Analysis
KW  - Healthy People 2000
KW  - Research Instruments
KW  - Data Analysis Software
KW  - Chi Square Test
KW  - Maxillofacial Injuries -- Prevention and Control
KW  - Child
KW  - Adolescence
KW  - Human
SP  - 82
EP  - 86
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 111
IS  - 1
PB  - Sage Publications Inc.
AB  - SPORTS-RELATED OROFACIAL trauma is a serious problem that can be prevented by wearing protective mouthguards and headgear. While this equipment is available, few studies have been done of wearing practices. This study assesses the wearing practices using data from the Child Health Supplement of the 1991 National Health Interview Survey. Results indicate that football was the only sport in which the majority of children used mouthguards and headgear. While statistically significant differences (p <.05) were found in use of the equipment in all sports by grade level, gender, parent's education, ethnicity, and by region of the country, these differences were not consistent across sports. Healthy People 2000 calls for extending requirements for use of orofacial protective devices to all organizations sponsoring sports that pose risk to injury. Given the complex nature of the findings, multifaceted initiatives that include the promulgation of rules must be developed and tested to determine what approaches are effective in ensuring consistent use.
SN  - 0033-3549
AD  - Disease Prevention and Health Prevention and Health Promotion Branch, National Institute of Dental Research, National Institutes of Health, Natcher Building, Room 3AN-44D, 45 Center Drive MSC 6401, Bethesda MD 20892-6401
U2  - PMID: 8610199.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107314384&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107378975
T1  - Quality assurance for cell processing: no more blind faith.
AU  - Read EJ
Y1  - 1996/01//
N1  - Accession Number: 107378975. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - Cell Transplantation -- Standards
KW  - Tissue Preservation -- Methods
KW  - Quality Assurance
SP  - 1
EP  - 4
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 36
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - Cell Processing Laboratory, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 8607147.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107378975&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107379009
T1  - From the NIH. NHLBI information services: a whole new world... National Heart, Lung, and Blood Institute.
AU  - Lenfant C
Y1  - 1996/01//
N1  - Accession Number: 107379009. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - National Institutes of Health (U.S.)
KW  - Information Services
KW  - Internet
KW  - Access to Information
KW  - Telephone Information Services
KW  - Heart Diseases -- Education
KW  - Hematologic Diseases -- Education
KW  - Information Resources
KW  - United States
SP  - 82
EP  - 83
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 36
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - National Heart, Lung, and Blood Institute, National Institutes of Health, Building 31, Room 5A52, 31 Center Drive MSC 2486, Bethesda, ME 20892
U2  - PMID: 8607160.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107379009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-45401-006
AN  - 2015-45401-006
AU  - Giedd, Jay N.
AU  - Allen, Albert J.
AU  - Behr, Raymond
T1  - Opportunities on the Internet for child and adolescent psychopharmacologists: Net access and mailing lists.
JF  - Journal of Child and Adolescent Psychopharmacology
JO  - Journal of Child and Adolescent Psychopharmacology
JA  - J Child Adolesc Psychopharmacol
Y1  - 1996///
VL  - 6
IS  - 2
SP  - 147
EP  - 150
CY  - US
PB  - Mary Ann Liebert, Inc.
SN  - 1044-5463
SN  - 1557-8992
AD  - Giedd, Jay N., National Institute of Mental Health, Child Psychiatry Branch, 9000 Rockville Pike, Building 10, Room 6N240, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-45401-006. Partial author list: First Author & Affiliation: Giedd, Jay N.; Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20170130. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Internet; Psychopharmacology; Scientific Communication; Websites; Multimedia. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 4. Issue Publication Date: 1996. 
AB  - The Internet, a system linking computers around the world, provides clinical and research psychopharmacologists with a convenient and efficient way to exchange information and offers a growing number of services to facilitate patient care. These opportunities are not theoretical, not in the future, and not for a select few. Many patients are already benefitting from practitioners who have sought guidance for their clinical work on the Internet. This article describes, for the novice user, how to begin the Internet journey. It also discusses psychopharmacology-related mailing lists, including a site that specializes in child and adolescent psychopharmacology. Subsequent articles will (1) show how to use Medlines to conduct literature searches and retrieve abstracts and articles from the computer screen, (2) describe ways to enter and traverse the World Wide Web (the 'multimedia' portion of Internet), and (3) survey the use of 'Web browsers' to find specialized psychopharmacology resources and databases, electronic journals, pertinent bulletin boards, and support services for patients and families—all with an emphasis on direct benefits to the practicing psychopharmacologist. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - Internet
KW  - psychopharmacologists
KW  - psychopharmacology
KW  - electronic journals
KW  - Web browsers
KW  - 1996
KW  - Internet
KW  - Psychopharmacology
KW  - Scientific Communication
KW  - Websites
KW  - Multimedia
KW  - 1996
DO  - 10.1089/cap.1996.6.147
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-45401-006&site=ehost-live&scope=site
UR  - jgiedd@helix.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13545-021
AN  - 2008-13545-021
AU  - Blottner, Dieter
AU  - Wolf, Nicole
AU  - Lachmund, Astrid
AU  - Flanders, Kathleen C.
AU  - Unsicker, Klaus
T1  - TGF-β rescues target-deprived preganglionic sympathetic neurons in the spinal cord.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1996/01//
VL  - 8
IS  - 1
SP  - 202
EP  - 210
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Unsicker, Klaus, Department of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, D-69120, Heidelberg, Germany
N1  - Accession Number: 2008-13545-021. PMID: 8713464 Partial author list: First Author & Affiliation: Blottner, Dieter; Department of Anatomy, Free University of Berlin, Berlin, Germany. Other Publishers: Blackwell Publishing. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cells (Biology); Cytokines; Spinal Cord; Sympathetic Nervous System; Neuroprotection. Minor Descriptor: Family Members; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 1996. 
AB  - Transforming growth factors β (TGF-β), a family of pleiotropic cytokines, are widely distributed in the developing and adult nervous system. In order to further determine the neural functions of TGF-β, we have localized the TGF-β isoforms 1, 2 and 3 in the adult rat adrenal medulla and studied the neuroprotective capacity of one representative family member, TGF-β2, for those spinal cord neurons which innervate adrenal chromaffin cells and which die after destruction of the adrenal medulla. Unilateral electrothermal destruction of the adrenal medulla led to the disappearance of 25% of sympathetic preganglionic neurons, which are located in the intermediolateral (IML) column of thoracic spinal cord segments 7-1 0 and can be selectively marked by NADPH-diaphorase. The neurons which disappeared following adrenomedullectomy constitute the full set of neurons that innervate the adrenal medulla. Implantation of gelfoam soaked with 0.5 μg TGF-β2 into the adrenal wound cavity rescued all spinal cord neurons in the IML ipsilaterally to the lesioned side. Cytochrome c was not effective. Injections of [¹²⁵I]TGF-β2 into the adrenal medulla did not result in retrograde transport and subsequent labelling of spinal cord neurons, suggesting that TGF-β may exert its neuroprotective actions by indirect mechanisms. TGF-β applied to cultured adrenocortical cells did not overtly increase the amount of mRNA for fibroblast growth factor-2, an established trophic molecule for sympathetic preganglionic spinal cord neurons. The mechanisms by which TGF-β exerts its neurotrophic effect are therefore unclear. Even so, our data provide the first evidence that TGF-β may play an important role in vivo in the control of maintenance of a population of spinal cord neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - transforming growth factors
KW  - preganglionic sympathetic neurons
KW  - spinal cord
KW  - cytokines
KW  - adrenal medulla
KW  - neuroprotection
KW  - chromaffin cells
KW  - rats
KW  - family member
KW  - 1996
KW  - Cells (Biology)
KW  - Cytokines
KW  - Spinal Cord
KW  - Sympathetic Nervous System
KW  - Neuroprotection
KW  - Family Members
KW  - Rats
KW  - 1996
U1  - Sponsor: Deutsche Forschungsgemeinschaft, Germany. Grant: SFB 317/C8. Recipients: No recipient indicated
DO  - 10.1111/j.1460-9568.1996.tb01181.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13545-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38277-002
AN  - 2015-38277-002
AU  - Nirenberg, Melissa J.
AU  - Vaughan, Roxanne A.
AU  - Uhl, George R.
AU  - Kuhar, Michael J.
AU  - Pickel, Virginia M.
T1  - The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/01//
VL  - 16
IS  - 2
SP  - 436
EP  - 447
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Nirenberg, Melissa J., Department of Neurology and Neuroscience, Cornell University Medical College, 411 East 69th Street, Room KB 410, New York, NY, US, 10021
N1  - Accession Number: 2015-38277-002. PMID: 8551328 Partial author list: First Author & Affiliation: Nirenberg, Melissa J.; Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Nirenberg, Melissa J. Major Descriptor: Axons; Dendrites; Neurons; Neurotoxins. Minor Descriptor: Striatum; Substantia Nigra. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Jan, 1996. Publication History: Accepted Date: Oct 9, 1995; Revised Date: Oct 5, 1995; First Submitted Date: Jul 11, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - Nigrostriatal dopaminergic neurons play an essential role in the central regulation of motor functions. These functions are initiated through the release of dopamine from axon terminals in the striatum or from dendrites in the substantia nigra (SN) and are terminated by the reuptake of dopamine by the sodium- and chloride-dependent dopamine transporter (DAT). DAT also can transport dopamine neurotoxins and has been implicated in the selective vulnerability of nigrostriatal dopaminergic neurons in major models of Parkinson's disease. We have used electron microscopic immunocytochemistry with an N-terminal domain anti-peptide antibody to examine the subcellular distribution of DAT in the rat SN and dorsolateral striatum. In the SN, immunogold labeling for DAT was localized to cytoplasmic surfaces of plasma membranes and smooth endoplasmic reticulum of dendrites and dendritic spines, few of which contained synaptic vesicles. Neuronal perikarya in the SN contained immunogold-labeled pleomorphic electron-lucent tubulovesicles but showed immunolabeling of plasma membranes only rarely. Axon terminals in the striatum contained extensive immunogold labeling of cytoplasmic surfaces of plasma membranes near aggregates of synaptic vesicles and less frequent labeling of intervaricose segments of plasma membrane or small electron-lucent vesicles. In sections dually labeled for DAT and the catecholamine-synthesizing enzyme tyrosine hydroxylase, both markers were colocalized in most profiles in the SN and striatum. These findings support the proposed topological model for DAT and suggest that this transporter is strategically located to facilitate uptake of dopamine and neurotoxins into distal dendritic and axonal processes of nigrostriatal dopaminergic neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dopamine transporter
KW  - dopamine reuptake
KW  - immunogold
KW  - substantia nigra
KW  - striatum
KW  - caudate-putamen
KW  - neurotoxicity
KW  - Parkinson’s disease
KW  - dendritic release
KW  - reverse transport
KW  - amphetamine
KW  - cocaine
KW  - 1996
KW  - Axons
KW  - Dendrites
KW  - Neurons
KW  - Neurotoxins
KW  - Striatum
KW  - Substantia Nigra
KW  - 1996
U1  - Sponsor: National Institute of General Medical Sciences, US. Grant: GM07739. Recipients: Nirenberg, Melissa J.
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH00078; MH40342. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: DA04600. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, Intramural Research Program, US. Recipients: Vaughan, Roxanne A.; Uhl, George R.; Kuhar, Michael J.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38277-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38277-009
AN  - 2015-38277-009
AU  - Du, Jing
AU  - Zhang, Lei
AU  - Weiser, Michael
AU  - Rudy, Bernardo
AU  - McBain, Chris J.
T1  - Developmental expression and functional characterization of the potassium-channel subunit Kv3.1b in parvalbumin-containing interneurons of the rat hippocampus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/01//
VL  - 16
IS  - 2
SP  - 506
EP  - 518
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - McBain, Chris J., Unit on Cellular and Synaptic Physiology, Laboratory of Cellular and Molecular Neurophysiology, NICHD, LCMN, Room 5A72, Building 49, 49 Convent Drive, MSC 4495, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-38277-009. PMID: 8551335 Partial author list: First Author & Affiliation: Du, Jing; Unit on Cellular and Synaptic Physiology, Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Rudy, Bernardo. Major Descriptor: Hippocampus; Immunocytochemistry; Interneurons; Potassium Channel. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 13. Issue Publication Date: Jan, 1996. Publication History: Accepted Date: Oct 12, 1995; Revised Date: Oct 10, 1995; First Submitted Date: Aug 10, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - The expression of the voltage-gated K+-channel subunit Kv3.1b in the developing hippocampus was determined by immunoblot and immunohistochemical techniques. Kv3.1b protein was detected first at postnatal day (P) 8. The Kv3.1b-immunopositive cell number per tissue section reached a maximum at P14 and was maintained through P40. In contrast, the Kv3.1b protein content of isolated membrane vesicles in immunoblots progressively increased through P40, suggesting an increase in Kv3.1b content per cell throughout this time period. Kv3.1b protein was expressed selectively in the somata, proximal dendrites, and axons of cells lying within or near the pyramidal cell layer, consistent with their being GABAergic inhibitory interneurons. Kv3.1b was present in ∼80% of parvalbumin-positive interneurons. The developmental onset of Kv3.1b and parvalbumin immunoreactivity was identical. In contrast, Kv3.1b was mostly absent from the subset of somatostatin-positive inhibitory interneurons. Electrophysiological recordings were made from stratum pyramidale interneurons in which morphology and Kv3.1b-positive immunoreactivity were confirmed post hoc. Outward currents had voltage-dependent and biophysical properties resembling those of channels formed by Kv3.1b. The current blocked by low concentrations of 4-aminopyridine (4-AP) showed marked inactivation, suggesting that Kv3.1b may coassemble with other members of the Kv3 subfamily. In current-clamp recordings, concentrations of 4-AP that blocked the current through Kv3.1b channels allowed us tentatively to assign a role to Kv3.1b-containing channels in action-potential repolarization. These data demonstrate that Kv3.1b is regulated developmentally in a specific subpopulation of hippocampal interneurons and that channels containing this subunit may be a major determinant in imparting 'fast-spiking' characteristics to these and other cells throughout the central nervous system containing the Kv3.1b subunit. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hippocampal interneurons
KW  - K+-channel subunits
KW  - Kv3.1
KW  - GABA
KW  - parvalbumin
KW  - immunohistochemistry
KW  - 1996
KW  - Hippocampus
KW  - Immunocytochemistry
KW  - Interneurons
KW  - Potassium Channel
KW  - Rats
KW  - 1996
U1  - Sponsor: National Institutes of Health, US. Grant: NS30989. Recipients: Rudy, Bernardo
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38277-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2009-05516-013
AN  - 2009-05516-013
AU  - McCarley, Robert W.
AU  - Hsiao, John K.
AU  - Freedman, Robert
AU  - Pfefferbaum, Adolf
AU  - Donchin, Emanuel
T1  - Neuroimaging and the cognitive neuroscience of schizophrenia.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1996///
VL  - 22
IS  - 4
SP  - 703
EP  - 723
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - McCarley, Robert W., Psychiatry 116A, Harvard Medical School/Brockton VA Medical Center, 940 Belmont St., Brockton, MA, US, 02401
N1  - Accession Number: 2009-05516-013. Partial author list: First Author & Affiliation: McCarley, Robert W.; Harvard Medical School/Brockton Veterans Affairs Medical Center, Brockton, MA, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognition; Neuroimaging; Neurosciences; Psychophysiology; Schizophrenia. Minor Descriptor: Technology; Cognitive Neuroscience. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 21. Issue Publication Date: 1996. 
AB  - The Carmel Workshop on Cognitive Psychophysiology began in 1980, and the focus of the 1996 workshop was on schizophrenia. Research into schizophrenia is in the midst of a period of unparalleled advance, driven in large part by improvements in neuroimaging technology that make detailed examination of in vivo brain structure and function possible. Neuroimaging studies may help provide a bridge between investigations demonstrating molecular and cellular abnormalities in schizophrenia and those demonstrating cognitive dysfunction. The workshop brought together experts in different neuroimaging modalities to present the strengths and advantages of each, as well as the insights each modality might bring into normal and schizophrenic cognition. It began with a series of tutorials to inform participants of the state of the art in various disciplines. It then broke into four panels, each given a very specific topic assignment related to neuroimaging and/or the cognitive neuroscience of schizophrenia. After 1½ days of discussion, each panel reported its conclusions to the workshop. Group I presented cellular models of the pathophysiology of schizophrenia. Group II examined experimental paradigms for studying cognitive function and schizophrenia. Group III examined technical issues in image processing and combining data across different modalities. Group IV sought to survey the current state of knowledge about the pathophysiology of schizophrenia. The conclusions of each of the groups are presented in this report. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuroimaging
KW  - cognitive neuroscience
KW  - schizophrenia
KW  - technology
KW  - 1996
KW  - Cognition
KW  - Neuroimaging
KW  - Neurosciences
KW  - Psychophysiology
KW  - Schizophrenia
KW  - Technology
KW  - Cognitive Neuroscience
KW  - 1996
DO  - 10.1093/schbul/22.4.703
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05516-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - FARAGGI, DAVID
AU  - KORN, EDWARD L.
T1  - Competing risks with frailty models when treatment affects only one failure type.
JO  - Biometrika
JF  - Biometrika
Y1  - 1996/01/02/
VL  - 83
IS  - 2
M3  - Article
SP  - 467
EP  - 471
SN  - 00063444
AB  - SUMMARY Using a model in which treatment affects only the failure type of primary clinical interest, the use of a cause-specific analysis is examined when the latent failure times are derived from a frailty model. The relationship between the cause-specific hazard ratio and the marginal hazard ratio is expressed in terms of a local dependence measure of the latent failure times. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FAILURE time data analysis
KW  - COPULA functions
KW  - LAPLACE transformation
KW  - DISTRIBUTION (Probability theory)
KW  - INVERSE functions
KW  - Cause-specific hazard ratio
KW  - Copula
KW  - Crude cumulative incidence curve
KW  - Hazard ratio
KW  - Survival data
N1  - Accession Number: 80075356; FARAGGI, DAVID 1 KORN, EDWARD L. 2; Affiliation:  1: Department of Statistics, University of Haifa Haifa, Israel  2: Biometric Research Branch, National Cancer Institute Bethesda, Maryland 20892, U. S.A.; Source Info: 1996, Vol. 83 Issue 2, p467; Subject Term: FAILURE time data analysis; Subject Term: COPULA functions; Subject Term: LAPLACE transformation; Subject Term: DISTRIBUTION (Probability theory); Subject Term: INVERSE functions; Author-Supplied Keyword: Cause-specific hazard ratio; Author-Supplied Keyword: Copula; Author-Supplied Keyword: Crude cumulative incidence curve; Author-Supplied Keyword: Hazard ratio; Author-Supplied Keyword: Survival data; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105854852
T1  - Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma.
AU  - Wigginton JM
AU  - Komschlies KL
AU  - Back TC
AU  - Franco JL
AU  - Brunda MJ
AU  - Wiltrout RH
Y1  - 1996/01/03/
N1  - Accession Number: 105854852. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antineoplastic Agents -- Therapeutic Use
KW  - Carcinoma, Renal Cell -- Drug Therapy
KW  - Interleukin 2 -- Therapeutic Use
KW  - Interleukins -- Therapeutic Use
KW  - Kidney Neoplasms -- Drug Therapy
KW  - Animals
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Drug Administration Schedule
KW  - Interleukin 2 -- Administration and Dosage
KW  - Interleukins -- Administration and Dosage
KW  - Mice
KW  - Physics
KW  - Survival Analysis
KW  - Animal Studies
SP  - 38
EP  - 43
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Experimental Immunology, National Cancer Institute, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
U2  - PMID: 8847724.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854852&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854853
T1  - Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma.
AU  - Janik JE
AU  - Miller LL
AU  - Longo DL
AU  - Powers GC
AU  - Urba WJ
AU  - Kopp WC
AU  - Gause BL
AU  - Curti BD
AU  - Fenton RG
AU  - Oppenheim JJ
AU  - Conlon KC
AU  - Holmlund JT
AU  - Sznol M
AU  - Sharfman WH
AU  - Steis RG
AU  - Creekmore SP
AU  - Alvord WG
AU  - Beauchamp AE
AU  - Smith JW 2nd
Y1  - 1996/01/03/
N1  - Accession Number: 105854853. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Melanoma -- Drug Therapy
KW  - Skin Neoplasms -- Drug Therapy
KW  - Adult
KW  - Aged
KW  - Antineoplastic Agents, Combined -- Adverse Effects
KW  - Chi Square Test
KW  - Clinical Trials
KW  - Female
KW  - HLA Antigens -- Blood
KW  - Indomethacin -- Administration and Dosage
KW  - Interleukin 1 -- Administration and Dosage
KW  - Male
KW  - Melanoma -- Immunology
KW  - Melanoma
KW  - Middle Age
KW  - Sex Factors
KW  - Skin Neoplasms -- Immunology
KW  - Skin Neoplasms -- Pathology
KW  - Treatment Outcomes
KW  - Human
SP  - 44
EP  - 49
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Biological Response Modifiers Program, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21701-4507, USA.
U2  - PMID: 8847725.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854853&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107145253
T1  - Alcohol use and prostate cancer risk in US Blacks and Whites.
AU  - Hayes RB
AU  - Brown LM
AU  - Schoenberg JB
AU  - Greenberg RS
AU  - Silverman DT
AU  - Schwartz AG
AU  - Swanson GM
AU  - Benichou J
AU  - Liff JM
AU  - Hoover RN
AU  - Pottern LM
Y1  - 1996/01/07/
N1  - Accession Number: 107145253. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Funded in part through National Cancer Institute contracts to the Michigan Cancer Foundation (NO1-CP-5109, NO1-CN-05225), the New Jersey State Dept of Health (NO1-CP-51089, NO1-CN-31022), the Georgia Center for Cancer Statistics (NO1-CP-51092, NO1-CN-05227), and Westat, Inc. (NO1-CP-51087). NLM UID: 7910653. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Ethanol -- Adverse Effects
KW  - Prostatic Neoplasms -- Epidemiology
KW  - Blacks
KW  - Whites
KW  - Case Control Studies
KW  - Race Factors
KW  - Self Report
KW  - Interviews
KW  - Odds Ratio
KW  - Logistic Regression
KW  - Chi Square Test
KW  - P-Value
KW  - Confidence Intervals
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 692
EP  - 697
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 143
IS  - 7
PB  - Oxford University Press / USA
AB  - Prostate cancer is the most common malignancy in US men (more than 165,000 cases per annum) and occurs substantially more frequently in blacks than in whites. The causes of this disease are, however, poorly understood. Alcohol consumption, which has been clearly related to malignancies of the upper aerodigestive tract, may also increase risk of cancer at other sites, including the prostate. The authors investigated alcohol use as a risk factor for prostate cancer among US blacks and whites. A population-based, case-control study was carried out among 981 men (479 blacks and 502 whites) with pathologically confirmed prostate cancer diagnosed between August 1, 1986, and April 30, 1989, and 1,315 controls (594 blacks and 721 whites) who resided in Atlanta, Georgia; Detroit, Michigan; and 10 counties in New Jersey, geographic areas covered by three population-based cancer registries. In-person interviews elicited information on alcohol use and other factors possibly related to prostate cancer. Compared with never-users, risk for prostate cancer increased with amount of alcohol drunk (chi-square[trend], P < 0.001), with significantly elevated risks seen for those who had 22-56 drinks per week (odds ratio = 1.4; 95% confidence interval 1.0-1.8) and 57 or more drinks per week (odds ratio = 1.9; 95% confidence interval 1.3-2.7). The finding was consistent among blacks (chi-square[trend], p < 0.01) and whites (chi-square[trend], P < 0.05), and among young and old subjects; it was not restricted to a specific type of alcoholic beverage. In this first large study among US blacks and whites, increased risk for prostate cancer was associated with increased alcohol use. The risk was similar for whites and blacks and could not be attributed to tobacco use or to a number of other potential confounders.
SN  - 0002-9262
AD  - Environmental Epidemiology Branch, National Cancer Institute, EPN 418, Bethesda, MD 20892
U2  - PMID: 8651231.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107145253&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107145256
T1  - Body size and breast cancer risk among women under age 45 years.
AU  - Swanson CA
AU  - Coates RJ
AU  - Schoenberg JB
AU  - Malone KE
AU  - Gammon MD
AU  - Stanford JL
AU  - Shorr IJ
AU  - Potischman NA
AU  - Brinton LA
Y1  - 1996/01/07/
N1  - Accession Number: 107145256. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653. 
KW  - Body Constitution
KW  - Breast Neoplasms -- Epidemiology
KW  - Case Control Studies
KW  - Interviews
KW  - Body Weights and Measures
KW  - Questionnaires
KW  - Body Mass Index
KW  - Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Multiple Logistic Regression
KW  - Descriptive Statistics
KW  - Relative Risk
KW  - P-Value
KW  - Risk Assessment
KW  - Adipose Tissue Distribution
KW  - Body Height
KW  - Spearman's Rank Correlation Coefficient
KW  - Body Weight
KW  - Adult
KW  - Female
KW  - Human
SP  - 698
EP  - 706
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 143
IS  - 7
PB  - Oxford University Press / USA
AB  - In a multicenter population-based case-control study that included 1,588 cases and 1,394 controls less than age 45 years, the authors examined the relation of adult body size and breast cancer risk among young women. Breast cancer patients and healthy controls were identified in Atlanta, Georgia; Seattle/Puget Sound, Washington; and central New Jersey. Cases were newly diagnosed with in situ or invasive breast cancer during the period of May 1, 1990, through December 31, 1992. Anthropometric variables thought to reflect early environmental factors (e.g., height, sitting height, frame size), obesity, and body fat distribution were measured directly. Height, but not sitting height or frame size, was a breast cancer risk factor. Risk of the disease was increased 46 percent among women in the fourth quartile of height (>167 cm) compared with women in the first quartile (<159 cm). Body weight, but not body fat distribution, was related to breast cancer risk. Risk of the disease was 35 percent lower among women in the highest quartile of Quetelet index (>28.8 kg/m2) compared with women in the lowest quartile (<22.0 kg/m2). Risk of the disease was increased about 2.1-fold (95 percent confidence interval 1.2-3.8) among women who were thin and tall compared with women who were heavy and short. Thus, breast cancer risk was increased substantially among younger women with a linear body type.
SN  - 0002-9262
AD  - Nutritional Epidemiology Section, Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPN Room 443, 6130 Executive Blvd, MSC 7374, Bethesda, MD 20892
U2  - PMID: 8651232.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107145256&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yoneyama, Mitsutoshi
AU  - Suhara, Wakako
AU  - Fukuhara, Yukiko
AU  - Sato, Mayumi
AU  - Ozato, Keiko
AU  - Fujita, Takashi
T1  - Autocrine Amplification of Type I Interferon Gene Expression Mediated by Interferon Stimulated Gene Factor 3 (ISGF3)1.
JO  - Journal of Biochemistry
JF  - Journal of Biochemistry
Y1  - 1996/01/07/
VL  - 120
IS  - 1
M3  - Article
SP  - 160
EP  - 169
SN  - 0021924X
N1  - Accession Number: 80129178; Yoneyama, Mitsutoshi 1 Suhara, Wakako 1 Fukuhara, Yukiko 1 Sato, Mayumi 1 Ozato, Keiko 2 Fujita, Takashi 1; Affiliation:  1: Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113  2: Department of Health and Human Services, National Institute of Child Health and Human Development Bethesda, Maryland 20892, USA; Source Info: 1996, Vol. 120 Issue 1, p160; Number of Pages: 10p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=80129178&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107329739
T1  - Prospective study of relative weight and risk of breast cancer: the Breast Cancer Detection Demonstration Project follow-up study, 1979 to 1987-1989.
AU  - Yong L
AU  - Brown CC
AU  - Schatzkin A
AU  - Schairer C
Y1  - 1996/01/10/
N1  - Accession Number: 107329739. Language: English. Entry Date: 19970701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653. 
KW  - Breast Neoplasms -- Epidemiology
KW  - Body Mass Index
KW  - Confidence Intervals
KW  - P-Value
KW  - Two-Tailed Test
KW  - Multivariate Analysis
KW  - Prospective Studies
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Cox Proportional Hazards Model
KW  - Risk Factors
KW  - Human
SP  - 985
EP  - 995
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 143
IS  - 10
PB  - Oxford University Press / USA
AB  - Despite extensive research on obesity and breast cancer in recent decades, inconsistencies in the literature exist. The authors examined prospectively the relation between adult relative weight (weight (kg)/height (m)1.5) and breast cancer risk in a cohort of 54,896 women aged 31-89 years who had previously participated in the Breast Cancer Detection Demonstration Project. During a mean follow-up period of 7 years, 226 of the premenopausal women and 1,198 of the postmenopausal women developed breast cancer. Analysis was performed using Cox proportional hazards regression methods with age as the underlying time variable and adjusted for the effects of potential confounders. Among postmenopausal women, the risk of breast cancer increased with increasing relative weight (p < 0.05 for trend); relative risk for the highest compared with the lowest quintile for relative weight was 1.3 (95% confidence interval (CI) 1.1-1.6). This association was modified by age at diagnosis, with relative risks of 1.1 (95% CI 0.8-1.4),1.2 (95% CI 0.8-1.7), and 1.8 (95% CI 1.3-2.5), respectively, for women aged <60, 60-64, and >/=65 years. The higher risk of breast cancer among the older and overweight women was largely confined to women whose weights were measured during the postmenopausal but not the premenopausal period. This risk pattern was observed among the naturally menopausal women, but was also apparent in the smaller group of women with bilateral oophorectomy or hysterectomy with one ovary retained. Among premenopausal women, adult relative weight was not associated with breast cancer risk. These findings suggest that the inconsistencies in the literature on obesity and breast cancer may be due in part to the differing age distributions of the populations studied. The authors conclude that prevention of obesity throughout adulthood, particularly after menopause, may help reduce breast cancer among older women.
SN  - 0002-9262
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD
U2  - PMID: 8629617.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107329739&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107266674
T1  - Ocular manifestations of AIDS.
AU  - Whitcup SM
AU  - Whitcup, S M
Y1  - 1996/01/10/
N1  - Accession Number: 107266674. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: journal article; case study; pictorial. Commentary: Flowers C W Jr, Baker R S. Kaposi sarcoma of the conjunctiva. (JAMA) 5/22/96; 275 (20): 1545-1545. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - AIDS-Related Opportunistic Infections
KW  - Cytomegalovirus Infections
KW  - Retinal Diseases
KW  - Antibiotics -- Therapeutic Use
KW  - Antiviral Agents -- Therapeutic Use
KW  - Antiviral Agents -- Adverse Effects
KW  - AIDS-Related Opportunistic Infections -- Diagnosis
KW  - AIDS-Related Opportunistic Infections -- Complications
KW  - AIDS-Related Opportunistic Infections -- Drug Therapy
KW  - AIDS-Related Opportunistic Infections -- Physiopathology
KW  - Retinal Diseases -- Complications
KW  - Retinal Diseases -- Diagnosis
KW  - Retinal Diseases -- Drug Therapy
KW  - Retinal Diseases -- Physiopathology
KW  - Adolescence
SP  - 142
EP  - 144
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 275
IS  - 2
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Md 20892-1858, USA
AD  - Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 8531310.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107266674&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854560
T1  - Epidemiologic determinants of seroreactivity to human papillomavirus (HPV) type 16 virus-like particles in cervical HPV-16 DNA-positive and-negative women.
AU  - Wideroff L
AU  - Schiffman MH
AU  - Hoover R
AU  - Tarone RE
AU  - Nonnenmacher B
AU  - Hubbert N
AU  - Kirnbauer R
AU  - Greer CE
AU  - Lorincz AT
AU  - Manos MM
AU  - Glass AG
AU  - Scott DR
AU  - Sherman ME
AU  - Buckland J
AU  - Lowy D
AU  - Schiller J
Y1  - 1996/01/11/
N1  - Accession Number: 105854560. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675. 
KW  - Antibodies, Viral -- Blood
KW  - Cervix Neoplasms
KW  - Cervix
KW  - DNA -- Analysis
KW  - Papillomaviruses -- Immunology
KW  - Viruses -- Immunology
KW  - Case Control Studies
KW  - Contraceptives, Oral -- Adverse Effects
KW  - Female
KW  - Male
KW  - Papillomaviruses
KW  - Sexuality
KW  - Human
SP  - 937
EP  - 943
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 174
IS  - 5
PB  - Oxford University Press / USA
SN  - 0022-1899
AD  - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892-7374, USA.
U2  - PMID: 8896493.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854560&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854580
T1  - Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis.
AU  - Mdluli K
AU  - Sherman DR
AU  - Hickey MJ
AU  - Kreiswirth BN
AU  - Morris S
AU  - Stover CK
AU  - Barry CE 3rd
AU  - Mdluli, K
AU  - Sherman, D R
AU  - Hickey, M J
AU  - Kreiswirth, B N
AU  - Morris, S
AU  - Stover, C K
AU  - Barry, C E 3rd
Y1  - 1996/01/11/
N1  - Accession Number: 105854580. Language: English. Entry Date: 20080314. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Z01 AI000783-11//Intramural NIH HHS/United States. NLM UID: 0413675. 
KW  - Antitubercular Agents -- Pharmacodynamics
KW  - Isoniazid -- Pharmacodynamics
KW  - Mycobacterium Tuberculosis -- Drug Effects
KW  - Oxidoreductases
KW  - Proteins
KW  - Biotransformation
KW  - Drug Resistance, Microbial
KW  - Genes
KW  - Isoniazid -- Metabolism
KW  - Lipids
KW  - Mutation
SP  - 1085
EP  - 1090
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 174
IS  - 5
PB  - Oxford University Press / USA
AB  - An examination of the pattern of lipid biosynthetic responses to isoniazid (INH) treatment of Mycobacterium tuberculosis and Mycobacterium smegmatis suggests that the mode of action of activated INH differs between these 2 organisms. Transformation of M. smegmatis with inhA on a plasmid construct conferred high-level resistance to INH, while the same construct failed to confer resistance upon M. tuberculosis. The inhA region from 2 clinical isolates whose resistance has been attributed to changes in the upstream promoter region has been cloned and was not sufficient to impart INH resistance to the level of the parent strain on sensitive M. tuberculosis. These putative mutant promoter elements appear to elevate expression levels of gene fusion reporter constructs, suggesting some noncausal connection between the observed mutations and the lipid metabolism of drug-resistant organisms. These results suggest that InhA is not the major target for activated INH in M. tuberculosis.
SN  - 0022-1899
AD  - Tuberculosis Research Unit, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
AD  - Tuberculosis Research Unit, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
U2  - PMID: 8896513.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854580&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854868
T1  - Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy.
AU  - Restifo NP
AU  - Marincola FM
AU  - Kawakami Y
AU  - Taubenberger J
AU  - Yannelli JR
AU  - Rosenberg SA
AU  - Restifo, N P
AU  - Marincola, F M
AU  - Kawakami, Y
AU  - Taubenberger, J
AU  - Yannelli, J R
AU  - Rosenberg, S A
Y1  - 1996/01/17/
N1  - Accession Number: 105854868. Language: English. Entry Date: 20080314. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Z01 BC010763-01//Intramural NIH HHS/United States. NLM UID: 7503089. 
KW  - Genes
KW  - Immunotherapy
KW  - Melanoma
KW  - Serum Globulins
KW  - Skin Neoplasms
KW  - Adult
KW  - Blotting, Northern
KW  - Blotting, Western
KW  - Cells
KW  - Documentation
KW  - Female
KW  - Immunohistochemistry
KW  - Male
KW  - Middle Age
KW  - Nucleotides
KW  - RNA
KW  - Skin Neoplasms -- Pathology
KW  - Skin Neoplasms -- Therapy
SP  - 100
EP  - 108
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 2
PB  - Oxford University Press / USA
AB  - Background: In a subset of patients with metastatic melanoma, T lymphocytes bearing the cell-surface marker CD8 (CD8+ T cells) can cause the regression of even large tumors. These antitumor CD8+ T cells recognize peptide antigens presented on the surface of tumor cells by major histocompatibility complex (MHC) class I molecules. The MHC class I molecule is a heterodimer composed of an integral membrane glycoprotein designated the alpha chain and a noncovalently associated, soluble protein called beta2-microglobulin (beta 2m). Loss of beta 2m generally eliminates antigen recognition by antitumor CD8+ T cells.Purpose: We studied the loss of beta 2m as a potential means of tumor escape from immune recognition in a cohort of patients receiving immunotherapy.Methods: We successfully grew 13 independent tumor cell cultures from tumor specimens obtained from 13 patients in a cohort of 40 consecutive patients undergoing immunotherapy for metastatic melanoma and for whom tumor specimens were available. These cell lines, as well as another melanoma cell line (called 1074mel) that had been derived from tumor obtained from a patient in a cytokine-gene therapy study, were characterized in vitro cytofluorometrically for MHC class I expression and by northern and western blot analyses for messenger RNA (mRNA) and protein expression, respectively, and ex vivo by immunohistochemistry.Results: After one melanoma cell line (1074mel) was found not to express functional beta 2m by cytofluorometric analysis, four (31%) of the 13 newly established melanoma cell lines were found to have an absolute lack of functional MHC class I expression. Northern blot analysis of RNA extracted from the five cell lines exhibiting no functional MHC class I expression showed that these cells contained normal levels of alpha-chain mRNA but variable levels of beta 2m mRNA. In addition, no immunoreactive beta 2m protein was detected by western blot analysis. When human beta 2m was transiently expressed with the use of a recombinant vaccinia virus, cell-surface MHC class I expression was reconstituted and the ability of these five cell lines to present endogenous antigens was restored. Immunohistochemical staining of tumor sections revealed a lack of immunoreactive MHC class I in vivo, supporting the notion that the in vitro observations were not artifactual. Furthermore, archival tumor sections obtained from patients prior to immunotherapy were available from three patients and were found to be beta 2m positive. This result was consistent with the hypothesis that loss of beta 2m resulted from immunotherapy.Conclusions: These data suggest that the loss of beta 2m may be a mechanism whereby tumor cells can acquire immunoresistance. This study represents the first characterization of a molecular route of escape of tumors from immune recognition in a cohort of patients being treated with immunotherapy.
SN  - 0027-8874
AD  - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
AD  - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 8537970.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854868&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854871
T1  - Chemoprevention of mammary carcinogenesis in the rat: combined use of raloxifene and 9-cis-retinoic acid.
AU  - Anzano MA
AU  - Peer CW
AU  - Smith JM
AU  - Mullen LT
AU  - Shrader MW
AU  - Logsdon DL
AU  - Driver CL
AU  - Brown CC
AU  - Roberts AB
AU  - Sporn MB
Y1  - 1996/01/17/
N1  - Accession Number: 105854871. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Breast Neoplasms -- Prevention and Control
KW  - Animals
KW  - Breast Neoplasms -- Chemically Induced
KW  - Estrogen Antagonists -- Administration and Dosage
KW  - Female
KW  - Piperidines -- Administration and Dosage
KW  - Raloxifene
KW  - Rats
KW  - Tretinoin -- Administration and Dosage
SP  - 123
EP  - 125
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 2
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 8537973.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854871&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107147565
T1  - Maternal smoking during pregnancy and childhood cancer.
AU  - Klebanoff MA
AU  - Clemens JD
AU  - Read JS
Y1  - 1996/01/22/
N1  - Accession Number: 107147565. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653. 
KW  - Smoking -- Complications -- In Pregnancy
KW  - Childhood Neoplasms -- Epidemiology
KW  - Prospective Studies
KW  - Blacks
KW  - Whites
KW  - P-Value
KW  - Two-Tailed Test
KW  - Cox Proportional Hazards Model
KW  - Confidence Intervals
KW  - Regression
KW  - Chi Square Test
KW  - T-Tests
KW  - Wilcoxon Rank Sum Test
KW  - Descriptive Statistics
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Pregnancy
KW  - Male
KW  - Female
KW  - Human
SP  - 1028
EP  - 1033
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 144
IS  - 11
PB  - Oxford University Press / USA
AB  - The association between maternal smoking during pregnancy and childhood cancer was investigated using prospectively collected data from 54,795 liveborn children in the Collaborative Perinatal Project (1959-1966). Cases of cancer had a histologic diagnosis and/or a compatible clinical course. There were 51 children with cancer, for a cumulative incidence of cancer of 1.1 per 1,000 by 96 months of age. Maternal smoking was determined at each prenatal visit; 52% of mothers reported smoking at one or more visits. By age 8 years, cancer had occurred in 1.4 per 1,000 children whose mothers did not smoke during pregnancy, compared with 0.9 per 1,000 children whose mothers smoked (p = 0.15 by log rank test); the hazard ratio was 0.67 (95% confidence interval (CI) 0.38-1.17). There was no dose-response effect of smoking compared with nonsmokers (hazard ratio for one to 10 cigarettes/day = 0.45, more than 10 cigarettes/day = 0.83). The hazard ratio for leukemia among children whose mothers smoked was 0.82 (95% CI 0.31-2.11); the hazard ratio for cancers other than leukemia was 0.60 (95% CI 0.30-1.20). Adjustment did not change the hazard ratio substantially. Although the relatively small number of cases precluded extensive study of individual types of cancer, the authors conclude that maternal smoking during pregnancy is not associated with an increased risk of childhood cancer in this cohort.
SN  - 0002-9262
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Bldg, Room 7B03, Bethesda, MD 20892-7510
U2  - PMID: 8942433.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107371324
T1  - Screening and treatment of sexually transmitted diseases: an important strategy for reducing the risk of HIV transmission.
AU  - Hitchcock PJ
Y1  - 1996/02//
N1  - Accession Number: 107371324. Language: English. Entry Date: 19960601. Revision Date: 20150818. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225. 
KW  - Sexually Transmitted Diseases -- Diagnosis
KW  - Sexually Transmitted Diseases -- Therapy
KW  - Acquired Immunodeficiency Syndrome -- Prevention and Control
KW  - HIV Infections -- Prevention and Control
KW  - Sexually Transmitted Diseases -- Epidemiology
KW  - HIV Infections -- Transmission
KW  - Acquired Immunodeficiency Syndrome -- Transmission
KW  - HIV Seropositivity -- Epidemiology
KW  - Male
KW  - Female
SP  - 10
EP  - 15
JO  - AIDS Patient Care & STDs
JF  - AIDS Patient Care & STDs
JA  - AIDS PATIENT CARE STDS
VL  - 10
IS  - 1
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1087-2914
AD  - Sexually Transmitted Diseases Branch, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Solar Bldg 3A24, Bethesda, MD 20892
U2  - PMID: 11361651.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107367695
T1  - Risk factors for infectious complications after abdominal surgery for malignant disease.
AU  - Velasco E
AU  - Thuler LCS
AU  - da Martins CAS
AU  - da Conalves VMS
Y1  - 1996/02//1996 Feb
N1  - Accession Number: 107367695. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854. 
KW  - Surgical Wound Infection -- Epidemiology
KW  - Risk Factors
KW  - Cancer Patients
KW  - Abdominal Neoplasms -- Surgery
KW  - Cross Infection -- Epidemiology
KW  - Brazil
KW  - Centers for Disease Control and Prevention (U.S.)
KW  - Prospective Studies
KW  - Multiple Logistic Regression
KW  - T-Tests
KW  - Chi Square Test
KW  - Fisher's Exact Test
KW  - Data Analysis Software
KW  - Confidence Intervals
KW  - Epidemiological Research
KW  - Multivariate Analysis
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 1
EP  - 6
JO  - American Journal of Infection Control
JF  - American Journal of Infection Control
JA  - AM J INFECT CONTROL
VL  - 24
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
AB  - Background: The emergence of nosocomial infection as a serious complication after intraabdominal operations for cancer prompted us to identify major independent risk factors associated with postoperative infection. Methods: Risk factors were studied in single and multivariate analyses. Variables considered were remote infection, antimicrobial prophylaxis, preoperative stay, chemotherapy, radiotherapy, weight loss, elective versus emergency operation, wound class, duration of operation, drains, sex, age, and physical status. Results: During 24 months, 236 patients were entered in the study. The overall postoperative infection rate was 45.7%; the surgical site infection rate was 22.4%. Multivariate analysis identified three independent variables: duration of operation longer than 5 hours (odds ratio 6.41, 95% confidence interval 3.28 to 12.54), presence of remote infection at operation (odds ratio 3.76, 95% confidence interval 1.76 to 8.03), and preoperative stay longer than 22 days (odds ratio 2.03, 95% confidence interval 1.04 to 3.95). The relative risk of infection increased from 3.0 when one risk factor was present to 7.3 when all three risk factors were present. Conclusions: The predictive power of our final multivariate risk index clearly groups these patients according to differing risk for postoperative infection. This classification contributes substantially to the effectiveness of infection control strategies to prevent the occurrence of postoperative infection in the high-risk population of patients with cancer.
SN  - 0196-6553
AD  - Infectious Disease Services and Hospital Infection Control Committee, National Cancer Institute, Rio de Janeiro, Brazil
U2  - PMID: 8651514.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sonnenberg, Amnon
AU  - Everhart, James E.
T1  - The Prevalence of Self-Reported Peptic Ulcer in the United States.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/02//
VL  - 86
IS  - 2
M3  - Article
SP  - 200
EP  - 200
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The purpose of this study was to draw a current picture of the sociodemographic characteristics of peptic ulcer in the United States. Methods. During the National Health Interview Survey of 1989, a special questionnaire on digestive diseases was administered to 41 457 randomly selected individuals. Data were retrieved from public use tapes provided by the National Center for Health Statistics. Odds ratios were calculated by logistic regression after adjustment for sample weights in the survey. Results. Of adult US residents, 10% reported having physician-diagnosed ulcer disease, and one third of these individuals reported having an ulcer in the past year. Old age, short education, low family income, being a veteran, and smoking acted as significant and independent risk factors. Gastric and duodenal ulcer occurred in both sexes equally often. Duodenal ulcer was more common in Whites than non-Whites, while gastric ulcer was more common in non-Whites. Conclusions. The age-related rise and socioeconomic gradients of peptic ulcer represent the historic scars of previous infection rates with Helicobacter pylori. The racial variations reflect different ages at the time of first infection; younger and older age at the acquisition of H. pylori appear to be associated with gastric and duodenal ulcer, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIODEMOGRAPHIC factors
KW  - PEPTIC ulcer
KW  - ULCERS
KW  - UNITED States
KW  - NATIONAL Center for Health Statistics (U.S.)
N1  - Accession Number: 9603040369; Sonnenberg, Amnon 1 Everhart, James E. 2; Affiliation:  1: Department of Veterans Affairs Medical Center, University of New Mexico, Albuquerque  2: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md.; Source Info: Feb1996, Vol. 86 Issue 2, p200; Subject Term: SOCIODEMOGRAPHIC factors; Subject Term: PEPTIC ulcer; Subject Term: ULCERS; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107364652
T1  - Experiences of cancer in children and adolescents.
AU  - Novakovic B
AU  - Fears TR
AU  - Wexler LH
AU  - McClure LL
AU  - Wilson DL
AU  - McCalla JL
AU  - Tucker MA
Y1  - 1996/02//1996 Feb
N1  - Accession Number: 107364652. Language: English. Entry Date: 19960401. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Sarcoma, Ewing's -- Psychosocial Factors -- In Infancy and Childhood
KW  - Cancer Survivors -- Psychosocial Factors
KW  - Childhood Neoplasms -- Psychosocial Factors
KW  - Unstructured Interview
KW  - Convenience Sample
KW  - Descriptive Statistics
KW  - Chi Square Test
KW  - T-Tests
KW  - Prospective Studies
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 54
EP  - 59
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 19
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - In an effort to understand the effect of cancer diagnosis and treatment in children and adolescents, and to identify issues that should be addressed with newly diagnosed patients, 85 patients with Ewing's sarcoma family tumors (ESFT) were interviewed about their experience of having cancer. This represents 90% of all eligible patients who survived at least 3 years since their diagnosis and who were treated for ESFT at the National Cancer Institute (NCI) from 1965-1993. The mean age of patients at the time of diagnosis was 15.8 + or - 5.3 years, and mean time since diagnosis was 13.6 + or - 6.4 years. Patients from this cohort had a disease usually related to poor outcome. Patients answered five open-ended written questions. Negative experiences that they described included transient and permanent discomfort and disabilities related to cancer; disruption of life or relationships; and emotional aspects of cancer diagnosis or treatment. Positive aspects of having cancer included changed attitudes about self and life, improved relationships with others, or better job performance. Advice for newly diagnosed patients most often dealt with the emotional aspects of cancer. The importance of patient-to-patient support was frequently described. Overall, having cancer was not an entirely negative experience, and it may result in introspection and improved relationships with others.
SN  - 0162-220X
AD  - National Cancer Institute, Executive Plaza North -- Room 439, Bethesda, MD 20892
U2  - PMID: 8904387.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107364655
T1  - Programmed instruction: biotherapy. Module IV. Interleukins.
AU  - DeLaPena L
AU  - Tomaszewski JG
AU  - Bernato DL
AU  - Kryk JA
AU  - Molenda J
AU  - Gantz S
Y1  - 1996/02//1996 Feb
N1  - Accession Number: 107364655. Language: English. Entry Date: 19960401. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Biological Therapy
KW  - Interleukins
KW  - Education, Continuing (Credit)
KW  - Interleukins -- Administration and Dosage
KW  - Interleukins -- Adverse Effects
KW  - Interleukins -- Physiology
KW  - Interleukin 1
KW  - Interleukin 2
KW  - Interleukin 3
KW  - Oncologic Nursing
SP  - 60
EP  - 75
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 19
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0162-220X
AD  - National Institutes of Health, Clinical Center, Department of Nursing, Bethesda, Maryland
U2  - PMID: 8904388.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Tomarev, Stanislav I.
AU  - Piatigorsky, Joram
T1  - Lens crystallins of invertebrates.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1996/02//2/1/96
VL  - 235
IS  - 3
M3  - Article
SP  - 449
EP  - 465
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The major proteins (crystallins) of the transparent, refractive eye lens of vertebrates are surprisingly diverse group of multifunctional proteins. A number of lens crystallins display taxon-specificity. In general, vertebrate crystallins have been recruited from stress-protective proteins (i.e. the small heat-shock proteins) and a member of metabolic enzymes by a gent-sharing mechanism. Despite the existence of refractive lenses in the complex and compound eyes of many invertebrates, relatively little is known about their crystallins. Here we review for the first time the state of knowledge of invertebrate crystallins. The major cephalopod (squid, octopus, and cuttlefish crystallins (S-crystallins) have, like vertebrate crystallins, been recruited from a stress protective metabolic enzyme, glutathione S-transferase. The presence of overlapping AP-1 and antioxidant responsive-like sequences that appear functional in transfected vertebrate cells suggests that the recruitment of glutathione S-transferase to S-crystallins involved response to oxidative stress. Cephalopods also have at least two taxon-specific crystallins: Ω-crystallin, related to aldehyde dehydrogenase, and O-crystallin, related to a superfamily of lipid-binding proteins, L-crystallin (probably identical to Ω-crystailin) is the major protein of the lens of the squid photophore, a specialized structure for emitting light. The use of L/Ω-crystallin in the ectodermal lens of the eye and the mesodermal lens of the photophore of the squid contrasts with the recruitment of different crystallins in the ectodermal lenses of the eye and photophore of fish. S- and Ω-crystallins appear to be lens-specific (some S-crystallins are also expressed in cornea) and, except for one S-crystallin polypeptide (SL11/Lops4; possibly a molecular fossil), lack enzymatic activity The S-crystallins (except SL11/Lops4) contain a variable peptide that has been inserted by exon shuffling. The only other invertebrate crystallins that have been examined are in one marine gastropod (Aplysia, a sea hare), in jellyfish and in the compound eyes of some arthropods; all are different and novel proteins. Drosocrystallin is one of three calcium binding taxon-specific crystallins found selectively in the acellular corneal lens of Drosophila, while antigen 3G6 is a highly conserved protein present in the ommatidial crystallin cone and central nervous system of numerous arthropods. Cubomedusan jellyfish have three novel crystallin families(the J-crystallins); the J1-crystallins are encoded in three very similar intronless genes with markedly different 5′ flanking sequences despite their almost identical encoded proteins and high lens expression. The numerous refractive structures that have evolved in the eyes of invertebrates contrast markedly with the limited information on their protein composition, making this field as exciting as it in underdeveloped. The similar requirement of Pax-6 (and possibly other common transcription factors) for eye development as well as the diversity, taxon-specificity and recruitment of stress-protective enzymes as crystallins suggest that borrowing multifunctional proteins for refraction by a gene sharing strategy may have occurred in invertebrates as it did in vertebrates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - CRYSTALLINE lens
KW  - ENZYMES
KW  - MOLLUSKS
KW  - GLUTATHIONE transferase
KW  - INVERTEBRATES
KW  - ALDEHYDE dehydrogenase
KW  - aldehyde dehydrogenase.
KW  - crystallin
KW  - glutathione s-transferase
KW  - invertebrates
KW  - lens
N1  - Accession Number: 13697505; Tomarev, Stanislav I. 1 Piatigorsky, Joram 1; Affiliation:  1: Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda MD, USA; Source Info: 2/1/96, Vol. 235 Issue 3, p449; Subject Term: PROTEINS; Subject Term: CRYSTALLINE lens; Subject Term: ENZYMES; Subject Term: MOLLUSKS; Subject Term: GLUTATHIONE transferase; Subject Term: INVERTEBRATES; Subject Term: ALDEHYDE dehydrogenase; Author-Supplied Keyword: aldehyde dehydrogenase.; Author-Supplied Keyword: crystallin; Author-Supplied Keyword: glutathione s-transferase; Author-Supplied Keyword: invertebrates; Author-Supplied Keyword: lens; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nesterova, Maria
AU  - Yokozaki, Hiroshi
AU  - McDuffie, Elwood
AU  - Cho-Chung, Yoon S.
T1  - Overexpresson of RIIβ regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RIIβ.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1996/02//2/1/96
VL  - 235
IS  - 3
M3  - Article
SP  - 486
EP  - 494
PB  - Wiley-Blackwell
SN  - 00142956
AB  - LS-174T human colon carcinoma cells that contain approximately equal amounts of cAMP-dependent protein kinase (PKA) isozymes, PKA-I and PKA-II, were infected with retroviral vectors coding for regulatory (R) and catalytic (C) subunits of human PKA. In cells overexpressing RIIα, RIIβ, and RIIβ-P (a RIIβ mutant at the autophosphorylation site), PKA-II levels increased while PKA-I levels decreased. PKA-I was almost completely eliminated in cells overexpressing RIIβ or RIIβ-P. In contrast, overexpressing of either RIα or Cα had little or no effect on PKA isozyme levels. Although all infectants expressed high levels of PKA subunit mRNAs in accordance with gene introduction, the R subunit protein expression was reflected in PKA isozyme levels rather than in subunit mRNA levels. Only RIIβ infectants demonstrated marked growth inhibition in monolayer culture, reduced thymidine incorporation into DNA, and inability to grow in semisolid medium or in serum-free medium. Conversely, all other infectants displayed growth properties similar to uninfected parental cells. The growth-retardation properties of RIIβ infectants were reflected in their altered phenotypic appearances. Our findings that the mutant RIIβ-P could not mimic the growth-inhibitory effect of RIIβ suggest the functional importance of the autophosphorylation site in RIIβ. Our results suggest a role for RIIβ in the suppression of neoplastic cell growth, and thus abnormal expression of R subunit isoforms of PKA may be involved in neoplastic transformation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER cells
KW  - PROTEIN kinases
KW  - ISOENZYMES
KW  - GENETIC transformation
KW  - COLON cancer
KW  - CELLULAR growth
KW  - gene transfer
KW  - growth inhibition
KW  - human cancer cells.
KW  - protein kinase a
KW  - site-directed mutation
N1  - Accession Number: 13698579; Nesterova, Maria 1 Yokozaki, Hiroshi 1 McDuffie, Elwood 1 Cho-Chung, Yoon S. 1; Affiliation:  1: The Cellular Biochemistry Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, USA; Source Info: 2/1/96, Vol. 235 Issue 3, p486; Subject Term: CANCER cells; Subject Term: PROTEIN kinases; Subject Term: ISOENZYMES; Subject Term: GENETIC transformation; Subject Term: COLON cancer; Subject Term: CELLULAR growth; Author-Supplied Keyword: gene transfer; Author-Supplied Keyword: growth inhibition; Author-Supplied Keyword: human cancer cells.; Author-Supplied Keyword: protein kinase a; Author-Supplied Keyword: site-directed mutation; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104789472
T1  - Contribution of dieting to the inverse association between energy intake and body mass index.
AU  - Ballard-Barbash, R
AU  - Graubard, I
AU  - Krebs-Smith, S M
AU  - Schatzkin, A
AU  - Thompson, F E
Y1  - 1996/02//1996 Feb
N1  - Accession Number: 104789472. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 8804070. 
KW  - Body Mass Index
KW  - Diet, Reducing -- Standards
KW  - Energy Intake -- Physiology
KW  - Energy Metabolism -- Physiology
KW  - Adult
KW  - Body Weight -- Physiology
KW  - Prospective Studies
KW  - Diet Records
KW  - Dietary Fats -- Pharmacodynamics
KW  - Female
KW  - Human
KW  - Middle Age
KW  - Surveys
KW  - Regression
KW  - United States
SP  - 98
EP  - 106
JO  - European Journal of Clinical Nutrition
JF  - European Journal of Clinical Nutrition
JA  - EUR J CLIN NUTR
VL  - 50
IS  - 2
CY  - London, <Blank>
PB  - Nature Publishing Group
SN  - 0954-3007
AD  - Applied Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 8641252.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107363341
T1  - Adjustment and social behaviour in older adults with chronic obstructive pulmonary disease: the family's perspective.
AU  - Leidy NK
AU  - Traver GA
Y1  - 1996/02//
N1  - Accession Number: 107363341. Language: English. Entry Date: 20050425. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Europe; Nursing; Peer Reviewed; UK & Ireland. Instrumentation: Katz Adjustment Scale for Relatives (KAS-R). Grant Information: American Lung Association. NLM UID: 7609811. 
KW  - Pulmonary Disease, Chronic Obstructive -- Psychosocial Factors -- In Old Age
KW  - Adaptation, Psychological -- In Old Age
KW  - Social Behavior -- In Old Age
KW  - Family Attitudes
KW  - Funding Source
KW  - Secondary Analysis
KW  - Sickness Impact Profile
KW  - Research Instruments
KW  - Pearson's Correlation Coefficient
KW  - T-Tests
KW  - Descriptive Statistics
KW  - Multitrait-Multimethod
KW  - Sex Factors
KW  - Middle Age
KW  - Aged
KW  - Human
SP  - 252
EP  - 259
JO  - Journal of Advanced Nursing
JF  - Journal of Advanced Nursing
JA  - J ADV NURS
VL  - 23
IS  - 2
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - This study employed secondary data analysis to explore family perceptions of adjustment and social behaviour in older adults (n = 51) with chronic obstructive pulmonary disease (COPD) and their relationship to published norms and patient self-report. According to the Katz Adjustment Scale for Relatives, these COPD patients had significantly higher levels of belligerence, negativism, helplessness, withdrawal, psychopathology, nervousness and confusion than reports from relatives of older adults from the general population. No differences were found in performance, expectation or dissatisfaction with socially expected activities, or performance of free-time activities. However, family members of COPD patients were significantly more dissatisfied with their relative's free-time activities. Although family perceptions of socially expected activities corresponded to patient descriptions of general and physical functioning (Sickness Impact Profile), patient perceptions of psychosocial functioning were independent of the family's. The results supported the tenet that older adults with COPD have difficulties with adjustment that may adversely affect social relationships, but were not consistent with the belief that the performance of socially expected or free-time activities is more impaired than in others of this age group. The data also suggested there may be some perceptual discrepancy between family and patient views of social behaviour.
SN  - 0309-2402
AD  - National Institutes of Health, Bldg 31, Rm 5B25, 31 Center Dr, Bethesda, Maryland 20892-2178
U2  - PMID: 8708236.
DO  - 10.1111/j.1365-2648.1996.tb02664.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107363341&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hertl, Michael
AU  - Asada, Hideo
AU  - Katz, Stephen I.
T1  - Murine epidermal Langerhans Cells Do Not Express the Low-Affinity Receptor for Immunoglobulin E, Fc∈RII (CD23).
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/02//
VL  - 106
IS  - 2
M3  - Article
SP  - 221
EP  - 224
SN  - 0022202X
AB  - The low-affinity receptor for IgE, Fc∈RII (CD23), plays an important role in IgE-mediated disorders such as allergy, atopy, and parasitic infections. In humans, the Fc∈RIIb isoform on epidermal Langerhans cells is thought to be an important accessory molecule in the allergen-specific T cell activation in atopic dermatitis. Since considerable knowledge about the accessory function of Langerhans cells for T-cell activation stems from mouse models, and since an IgE-bearing Langerhans cell mouse model would be useful in studying the pathophysiology of atopic dermatitis, we determined whether Fc∈RII was also present on murine Langerhans cells. Fc∈RIIa, which is the major Fc∈RII isoform in mice, was found to be constitutively expressed on spleen cells from normal mice but was not present on epidermal Langerhans cells. When interleukin-4, a known inducer of Fc∈RII, was administered <em>in vivo</em>, Fc∈RII-specific mRNA and protein was significantly upregulated in spleen cells but not in Langerhans cells. <em>De novo</em> synthesis of Fc∈RII was also induced <em>in vitro</em> by interleukin-4 on spleen cells, but not on epidermal cells. The presence of a recently cloned murine counterpart to the human Fc∊RIIb isoform on murine Langerhans cells could also be excluded on the protein and mRNA level because of the high degree of homology to mouse Fc∈RIIa. Taken together the data indicate that murine epidermal Langerhans cells do not express the low-affinity receptor for IgE. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - IMMUNOGLOBULIN E
KW  - T cells
KW  - ATOPIC dermatitis
KW  - PATHOLOGICAL physiology
KW  - MESSENGER RNA
KW  - interferon-γ
KW  - interleukin-4
KW  - mouse CD23
KW  - trypsin
N1  - Accession Number: 12340546; Hertl, Michael 1 Asada, Hideo 2 Katz, Stephen I. 2; Affiliation:  1: Hautklinik der RWTH, Pauwelsstrasse 30, D-52074 Aachen, Germany  2: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Feb96, Vol. 106 Issue 2, p221; Subject Term: LANGERHANS cells; Subject Term: IMMUNOGLOBULIN E; Subject Term: T cells; Subject Term: ATOPIC dermatitis; Subject Term: PATHOLOGICAL physiology; Subject Term: MESSENGER RNA; Author-Supplied Keyword: interferon-γ; Author-Supplied Keyword: interleukin-4; Author-Supplied Keyword: mouse CD23; Author-Supplied Keyword: trypsin; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12340546
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12340546&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Li, Luowei
AU  - Tennenbaum, Tamar
AU  - Yuspa, Stuart H.
T1  - Suspension-Induced Murine Keratinocyte Differentiation Is Mediated by Calcium.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/02//
VL  - 106
IS  - 2
M3  - Article
SP  - 254
EP  - 260
SN  - 0022202X
AB  - Modulating extracellular Ca2+ (Cao) and suspension culture are two frequently used methods to induce maturation of cultured human and mouse keratinocytes. To determine if the two methods share a common mechanism, changes in Ca2+ metabolism were studied in suspension cultures of mouse keratinocytes. Spontaneously detached and suspensioncultured keratinocytes in 0.05 mM Ca2+ medium express markers of suprabasal differentiation, while 0.05 mM Ca2+ is not permissive for marker expression by attached keratinocytes. Intracellular free Ca2+ (Cai increased rapidly after placing keratinocytes in suspension in 0.05 mM Ca2+, reaching levels up to 3to 4-fold higher than Cai in attached cells after 4-5 h. In suspended cells, the increase in Cai was associated with a 2- to 6-fold increase in Ca2+ transport across plasma membrane as well as depletion of intracellular Ca2+-stores. Differentiation marker expression and terminal differentiation were inhibited in suspension-cultured keratinocytes by preventing the rise of Cai using either 1,2-bis(o-aminophenoxy)-ethaneN,N,N',N'-tetraacetic acid to chelate intracellular Ca2+ or ethyleneglycol-bis(β-aminoethyl ether)N,N,N',N'-tetraacetic acid to reduce Cao. Together, these results indicate that a rise in Cai is a common mechanism controlling differentiation in cultured mouse keratinocytes, and suspension of keratinocytes enhances Ca2+ transport and alters intracellular Ca2+ sequestration producing a rise in Cai. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - SUSPENSIONS (Chemistry)
KW  - CALCIUM
KW  - METABOLISM
KW  - ORGANIC acids
KW  - SEQUESTRATION (Chemistry)
N1  - Accession Number: 12340654; Li, Luowei 1 Tennenbaum, Tamar 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Feb96, Vol. 106 Issue 2, p254; Subject Term: KERATINOCYTES; Subject Term: SUSPENSIONS (Chemistry); Subject Term: CALCIUM; Subject Term: METABOLISM; Subject Term: ORGANIC acids; Subject Term: SEQUESTRATION (Chemistry); Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12340654
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12340654&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Memar, Omeed M.
AU  - Rajaraman, Srinivasan
AU  - Thotakura, Rao
AU  - Tyring, Stephen K.
AU  - Fan, Ji-Lao
AU  - Seetharamaiah, Gattadahalli S.
AU  - Lopez, Angel
AU  - Jordon, Robert E.
AU  - Prabhakar, Bellur S.
T1  - Recombinant Desmoglein 3 Has the Necessary Epitopes to Adsorb and Induce Blister-Causing Antibodies.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/02//
VL  - 106
IS  - 2
M3  - Article
SP  - 261
EP  - 268
SN  - 0022202X
AB  - The development of an animal model for studying the pathogenesis of pemphigus vulgaris (PV) has been hampered by the unavailability of the purified full length autoantigen desmoglein 3 (Dsg 3). Therefore, we expressed Dsg 3 using a baculovirus expression system. The expressed protein was identified as Dsg 3 by its reactivity with a pan-cadherln anti-serum, an anti-serum to a Dsg 3 synthetic peptide, or patient serum, and by amino-terminal sequencing. Carbohydrate analysis showed that recombinant Dsg 3 was glycosylated. While a majority of the recombinant protein was cell associated, by immunoprecipitation, some Dsg 3 was demonstrated in the medium. The Dsg 3 could adsorb out blister-causing antibodies from patient sera. Rabbit anti-Dsg 3 antibodies induced by the recombinant Dsg 3 showed specific binding to intercellular spaces of monkey esophagus by indirect immunofluorescence. Moreover, these antibodies induced PV-like blisters in neonatal mice and weakly bound perilesional epidermis. Availability of large quantities of relatively pure Dsg 3 should now facilitate studies aimed at understanding Dsg 3 structure and pathogenesis of PV, with implications for developing specific immunotherapies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENIC determinants
KW  - BLISTERS
KW  - IMMUNOGLOBULINS
KW  - PEMPHIGUS
KW  - BACULOVIRUSES
KW  - CARBOHYDRATES
KW  - acantholysis
KW  - Autoimmunity
KW  - baculovirus
KW  - pemphigus vulgaris
N1  - Accession Number: 12340663; Memar, Omeed M. 1 Rajaraman, Srinivasan 2 Thotakura, Rao 3 Tyring, Stephen K. 4,5 Fan, Ji-Lao 1 Seetharamaiah, Gattadahalli S. 1 Lopez, Angel 1 Jordon, Robert E. 6 Prabhakar, Bellur S. 1; Affiliation:  1: Department of Microbiology and Immunology,University of Texas Medical Branch, Galveston, Texas  2: Department of Pathology, University of Texas Medical Branch, Galveston, Texas  3: Molecular and Cellular Endocrinology Branch, National Institutes of Health, Bethesda, Maryland  4: Department of Dermatology, University of Texas Medical Branch, Galveston, Texas  5: Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas  6: Department of Dermatology, University of Texas Medical School at Houston, Houston, Texas, U.S.A.; Source Info: Feb96, Vol. 106 Issue 2, p261; Subject Term: ANTIGENIC determinants; Subject Term: BLISTERS; Subject Term: IMMUNOGLOBULINS; Subject Term: PEMPHIGUS; Subject Term: BACULOVIRUSES; Subject Term: CARBOHYDRATES; Author-Supplied Keyword: acantholysis; Author-Supplied Keyword: Autoimmunity; Author-Supplied Keyword: baculovirus; Author-Supplied Keyword: pemphigus vulgaris; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12340663
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12340663&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hengge, Ulrich R.
AU  - Chan, Edward F.
AU  - Hampshire, Victoria
AU  - Foster, Ruth A.
AU  - Vogel, Jonathan C.
T1  - The Derivation and Characterization of Pig Keratinocyte Cell Lines That Retain the Ability to Differentiate.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/02//
VL  - 106
IS  - 2
M3  - Article
SP  - 287
EP  - 293
SN  - 0022202X
AB  - Pig skin may be a very useful model for studying human skin biology, since its morphology closely resembles that of human skin. To manipulate pig keratinocytes <em>in vitro</em>, we have analyzed different culture conditions for optimal pig keratinocyte growth and describe here a simple method for culture and extended passage of primary pig keratinocytes on collagen substrates. The colony-forming efficiency and proliferative capacity of primary pig keratinocytes were readily supported by Type I collagen and a final calcium concentration of 0.075 mM. These culture conditions permitted efficient gene transfer into keratinocytes using various cationic lipids at a 4:1 ratio (lipid:DNA). In addition, immortalized pig keratinocyte cell lines, which maintained a normal phenotype, were derived using these optimized culture conditions. By karyotype analysis, two independently derived cell lines had the same chromosomal abnormalities, suggesting a causal role in their immortalization. The keratinocyte cell lines exhibited a differentiated phenotype in response to elevated calcium concentration and were nontumorigenic in <em>in vivo</em> tumor assays. Immortalized pig keratinocyte cell lines that maintain the ability to differentiate may become a valuable tool in the study of epidermal differentiation both <em>in vitro</em> and <em>in vivo</em>. In addition, methods using keratinocytes to deliver genes to pigs <em>in vivo</em> could also be enhanced with these pig keratinocyte cell lines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - CELL lines
KW  - SKIN
KW  - COLLAGEN
KW  - KARYOTYPES
KW  - GENES
KW  - β-galactosidase
KW  - Collagen
KW  - differentiation
KW  - gene transfer
N1  - Accession Number: 12340722; Hengge, Ulrich R. 1 Chan, Edward F. 1 Hampshire, Victoria 2 Foster, Ruth A. 1 Vogel, Jonathan C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health (NIH), NIH, Bethesda, Maryland, U.S.A.  2: National Center for Research Resources, Veterinary Resources Program, National Institutes of Health (NIH), NIH, Bethesda, Maryland, U.S.A.; Source Info: Feb96, Vol. 106 Issue 2, p287; Subject Term: KERATINOCYTES; Subject Term: CELL lines; Subject Term: SKIN; Subject Term: COLLAGEN; Subject Term: KARYOTYPES; Subject Term: GENES; Author-Supplied Keyword: β-galactosidase; Author-Supplied Keyword: Collagen; Author-Supplied Keyword: differentiation; Author-Supplied Keyword: gene transfer; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12340722
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12340722&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kartasova, Tonja
AU  - Darwiche, Nadine
AU  - Kohno, Yohko
AU  - Koizumi, Hiroko
AU  - Osada, Shin-ichi
AU  - Huh, Nam-ho
AU  - Lichti, Ulrike
AU  - Steinert, Peter M.
AU  - Kuroki, Toshio
T1  - Sequence and Expression Patterns of Mouse SPR1: Correlation of Expression with Epithelial Function.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/02//
VL  - 106
IS  - 2
M3  - Article
SP  - 294
EP  - 304
SN  - 0022202X
AB  - A final event in the terminal differentiation of stratified squamous epithelia is the formation of a cornifled cell envelope, which is a complex of several proteins cross-linked together by transglutaminases. One set of proteins is the family of small proline rich (SPR) proteins. In human foreskin epidermal cell envelopes, SPRs serve as cross-bridging proteins among the more abundant loricrin. In order to study further their evolution and expression, we have isolated and sequenced cDNAs encoding two mouse SPR1 proteins, SPR1a and SPR1b. Comparative sequence analyses showed the preservation of the overall structure of mammalian SPR1 proteins with highly conserved termini and a central peptide domain repeated 13 (SPR1a) or seven (SPR1b) times. Tissues obtained from mouse fetal, newborn, and adult skin were tested by Northern blot analyses, in situ hybridization, and immunohistochemistry using an antibody raised to a synthetic peptide corresponding to the C terminus of the SPR1a protein. Skin expression was first detected in fetal periderm, in anagen hair follicles of newborn and older mice, and in the thickened epidermis of the lip and footpad, but no signal was detected in interfollicular trunk epidermis. High levels of SPR1a expression were found in epithelia from the forestomach and penis, and in benign squamous papillomas. Other epithelia expressing SPR1a include the tongue, esophagus, and vagina. Whenever detected, SPR1a positive staining was present in the spinous and granular layers. In the forestomach and papillomas, the periphery of cells in the cornified layer was also stained. Our results suggest that SPR1a participates widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPITHELIUM
KW  - MICE
KW  - CELLS
KW  - TRANSGLUTAMINASES
KW  - PROTEINS
KW  - PEPTIDES
KW  - cDNA
KW  - epithelium
KW  - small proline rich
N1  - Accession Number: 12340741; Kartasova, Tonja 1 Darwiche, Nadine 2 Kohno, Yohko 3 Koizumi, Hiroko 4 Osada, Shin-ichi 5 Huh, Nam-ho 1 Lichti, Ulrike 2 Steinert, Peter M. 6 Kuroki, Toshio 1; Affiliation:  1: Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan  2: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, U.S.A.  3: Department of Oral Pathology, Showa University School of Dentistry, Tokyo, Japan  4: Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan  5: Department of Molecular Biology, Yokohama City University, School of Medicine, Yokohama, Japan  6: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, U.S.A.; Source Info: Feb96, Vol. 106 Issue 2, p294; Subject Term: EPITHELIUM; Subject Term: MICE; Subject Term: CELLS; Subject Term: TRANSGLUTAMINASES; Subject Term: PROTEINS; Subject Term: PEPTIDES; Author-Supplied Keyword: cDNA; Author-Supplied Keyword: epithelium; Author-Supplied Keyword: small proline rich; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3  - 10.1111/1523-1747.ep12340741
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12340741&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107384312
T1  - Relationship between skeletal muscle intracellular ionized magnesium and measurements of blood magnesium.
AU  - Ryschon TW
AU  - Rosenstein DL
AU  - Rubinow DR
AU  - Niemela JE
AU  - Elin RJ
AU  - Balaban RS
Y1  - 1996/02//1996 Feb
N1  - Accession Number: 107384312. Language: English. Entry Date: 19961001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0375375. 
KW  - Magnesium -- Analysis
KW  - Blood -- Analysis
KW  - Muscle, Skeletal
KW  - Spectrum Analysis
KW  - Magnetic Resonance Imaging
KW  - Magnesium -- Metabolism
KW  - In Vitro Studies
KW  - Descriptive Statistics
KW  - Pearson's Correlation Coefficient
KW  - Type I Error
KW  - Confidence Intervals
KW  - Linear Regression
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 207
EP  - 213
JO  - Journal of Laboratory & Clinical Medicine
JF  - Journal of Laboratory & Clinical Medicine
JA  - J LAB CLIN MED
VL  - 127
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - The current laboratory approach to assessing magnesium status is based on determining the concentration of total Mg ((Mg)) in serum or plasma. This strategy is problematic in that the amount of Mg in blood is less than 1 % of total body Mg and does not accurately reflect (Mg) in other tissues. Furthermore, the (Mg) of blood does not distinguish biologically active, ionized Mg from the bound fraction. The goal of this study was to determine intracellular ionized Mg ((Mg++)i) of skeletal muscle in vivo and to compare results with the (Mg) of blood constituents. (Mg++)i was determined in resting skeletal muscle by using phosphorus 31 magnetic resonance (31P-MR) spectroscopy. (Mg) was measured in serum (S(Mg)), serum ultrafiltrate (UF(Mg)), mononuclear blood cells (MBC(Mg)), and red blood cells (RBC(Mg)) by using atomic absorption spectroscopy or a colorimetric assay. In a sample of 60 healthy adult subjects, skeletal muscle (Mg++)i = 557 +/- 97 micromol/L (mean + SD); S(Mg) = 0.78 +/- 0.09 mmol/L; UF(Mg) = 0.60 +/- 0.12 mmol/L; MBC(Mg) = 13.8 +/- 2.3 mmol/L; and, RBC(Mg) = 1.92 +/- 0.33 mmol/L. A significant negative correlation was found between (Mg++)i and S(Mg) (r = -0.43, p < 0.05). S(Mg) was significantly lower (p < 0.05) and (Mg++)i significantly higher (p < 0.05) in women than in men, but neither was related to age. These findings provide new insight into the relationship between blood Mg measures and (Mg++)i of the largest soft tissue mass of the human body.
SN  - 0022-2143
AD  - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 1, Room B3-07, Bethesda, MD 20892
U2  - PMID: 8636650.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107384312&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107377941
T1  - Mobility in older patients with hip fractures: examining prefracture status, complications, and outcomes at discharge from the acute-care hospital.
AU  - Myers AH
AU  - Palmer MH
AU  - Engel BT
AU  - Warrenfeltz DJ
AU  - Parker JA
Y1  - 1996/02//
N1  - Accession Number: 107377941. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 8807705. 
KW  - Hip Injuries -- In Old Age
KW  - Fractures -- In Old Age
KW  - Fractures -- Complications -- In Old Age
KW  - Treatment Outcomes
KW  - Physical Mobility
KW  - Activities of Daily Living -- Evaluation -- In Old Age
KW  - Chi Square Test
KW  - Self Care -- Evaluation -- In Old Age
KW  - T-Tests
KW  - Retrospective Design
KW  - Risk Factors -- Evaluation -- In Old Age
KW  - Multiple Logistic Regression
KW  - Outcomes Research
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 99
EP  - 107
JO  - Journal of Orthopaedic Trauma
JF  - Journal of Orthopaedic Trauma
JA  - J ORTHOP TRAUMA
VL  - 10
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The purpose of this study was to examine the relationships among prefracture status, development of complications, mobility outcomes at discharge, and disposition at discharge. We singled out a case series of consecutive noninstitutionalized elderly persons hospitalized for hip fracture (ICD 820.0-820.9) at two Baltimore hospitals during 1992-1993. Data were abstracted from the medical records for the following variables: sociodemographic information, prefracture status, selected medical conditions, injury and surgical treatment, complications, functional mobility and assistance needed at discharge, and disposition. Factors associated with four complications were identified from multiple logistic regression analyses. (a) Prefracture needs for assistance with activities of daily living (ADL), and age >/= 80, were associated with the development of pressure ulcers. (b) Male gender and prefracture urinary incontinence (UI) were associated with pneumonia. (c) Prefracture UI and weight-bearing status were associated with UI after removal of an indwelling catheter. (d) Age >/= 80 was associated with urinary retention. The amount of assistance needed for mobility tasks at discharge was associated with prefracture need for assistance with ADLs, gender, weight-bearing status, and hospitals with shorter lengths of stay and fewer physical therapy sessions. Patients who were older and had shorter lengths of stay and less physical therapy were more likely to go to another health facility than directly home. Prefracture status (ADL, prefracture UI) was significantly associated with the development of complications. Prefracture needs for assistance with ADL and complications were associated with mobility outcomes at discharge. These prefracture factors have an effect on outcomes and need to be addressed in the development of critical pathways for case treatment. Specific protocols for subgroups of patients may need to be designed and evaluated.
SN  - 0890-5339
AD  - Laboratory of Behavioral Sciences, National Institute on Aging, Gerontology Research Center, 4940 Eastern Avenue, Baltimore, MD 21224
U2  - PMID: 8932668.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107377941&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107123454
T1  - The Women and Infants Transmissions Study (WITS) of maternal-infant HIV transmission: study design, methods, and baseline data.
AU  - Sheon AR
AU  - Fox HE
AU  - Rich KC
AU  - Stratton P
AU  - Diaz C
AU  - Tuomala R
AU  - Mendez H
AU  - Carrington J
AU  - Alexander G
Y1  - 1996/02//1996 Feb
N1  - Accession Number: 107123454. Language: English. Entry Date: 20000801. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Disease Transmission, Vertical
KW  - Human Immunodeficiency Virus -- Transmission
KW  - Disease Progression
KW  - Female
KW  - Infant
KW  - Adult
KW  - Blacks
KW  - Whites
KW  - Hispanics
KW  - Prospective Studies
KW  - Epidemiological Research
KW  - HIV-Infected Patients
KW  - Poverty
KW  - Pregnancy
KW  - Research Subject Recruitment
KW  - Community Health Services
KW  - Structured Interview
KW  - Patient History Taking
KW  - Risk Taking Behavior
KW  - Pregnancy Outcomes
KW  - P-Value
KW  - Research Dropouts
KW  - Demography
KW  - United States
KW  - Hospitals
KW  - Human
SP  - 69
EP  - 78
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 5
IS  - 1
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - Our objective is to describe the Women and Infants Transmission Study (WITS) design, data collection methods, and study cohort characteristics. WITS is a prospective epidemiologic study of the natural history of HIV infection in pregnant women and their infants carried out at obstetric/gynecologic and pediatric clinics in Boston, Chicago, Manhattan, Brooklyn, San Juan, and Houston. The participants were 788 HIV-infected pregnant women and 657 infants born to them. The main outcome measures were clinical and laboratory factors associated with maternal-infant transmission and disease progression in mothers and infants. Eighty-two percent of pregnant women in WITS are women of color. Seventy-two percent of the pregnant women and 81% of infants enrolled as of June 30,1993, remained in follow-up in March 1994. Among infants followed for at least 6 months from birth and on whom HIV culture results were available, 55 of 310 were infected, with a transmission rate of 17.7%. The WITS has recruited a cohort of HIV-infected pregnant women and their infants who are broadly representative of infected women and infants in the United States. Retention of a cohort of predominantly low-income women, many with chronic substance abuse histories, is challenging but possible. The study is assessing determinants of maternal-infant transmission and disease progression.
SN  - 1059-7115
AD  - National Institutes of Health, 6003 Executive Blvd, Rockville, MD 20892-7620
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107123454&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Reid Lyon, G.
AU  - Chhabra, Vinita
T1  - THE CURRENT STATE OF SCIENCE AND THE FUTURE OF SPECIFIC READING DISABILITY.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1996/02//
VL  - 2
IS  - 1
M3  - Article
SP  - 2
EP  - 9
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - We review critical scientific advances in specific reading disability. We summarize research findings relevant to genetic neurobiological, and cognitive etiologies, as well as data related to early identification, developmental course, and response to treatment Intervention. Converging scientific findings are applied to the development of a proposed new definition of dyslexia and future research directions an outlined. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - READING disability
KW  - NEUROBIOLOGY
KW  - COGNITION disorders
KW  - DISEASES -- Causes & theories of causation
KW  - DYSLEXIA
KW  - HUMAN abnormalities
KW  - definition
KW  - developmental course
KW  - dyslexia
KW  - learning disability
KW  - neuroimaging
KW  - treatment
N1  - Accession Number: 12389790; Reid Lyon, G. 1 Chhabra, Vinita 2; Affiliation:  1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (GRL).  2: The University of Virginia (VC).; Source Info: 1996, Vol. 2 Issue 1, p2; Subject Term: READING disability; Subject Term: NEUROBIOLOGY; Subject Term: COGNITION disorders; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: DYSLEXIA; Subject Term: HUMAN abnormalities; Author-Supplied Keyword: definition; Author-Supplied Keyword: developmental course; Author-Supplied Keyword: dyslexia; Author-Supplied Keyword: learning disability; Author-Supplied Keyword: neuroimaging; Author-Supplied Keyword: treatment; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rumsey, Judith M.
T1  - DEVELOPMENTAL DYSLEXIA: ANATOMIC AND FUNCTIONAL NEUROIMAGING.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1996/02//
VL  - 2
IS  - 1
M3  - Article
SP  - 28
EP  - 38
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - Developmental dyslexia has come to be viewed as a language disorder involving phonologic deficits. This view has greatly influenced imaging studies of dyslexia, with the result that anatomic studies have primarily focused on language relevant brain structures and functional studies have examined language-related functions. Although inconsistent in their methods and findings, both neuroanatomic imaging studies using computed tomography and magnetic resonance imaging and postmortem studies, suggest that asymmetries of the planum temporale and other language-relevant structures, as well as the morphology of the corpus callosum, warrant further study using improved methods now available. Functional imaging studies using xenon inhalation techniques and positron emission tomography suggest altered left temporoparietal and bilateral temporal function. An emergent interest in difficulties with rapid temporal ( i.e. sequential) processing, particularly within the visual system, is also noteworthy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DYSLEXIA
KW  - DEVELOPMENTAL disabilities
KW  - LANGUAGE disorders
KW  - NEUROANATOMY
KW  - EMISSION tomography
KW  - IMAGING systems in medicine
KW  - dyslexia
KW  - neuroimaging
N1  - Accession Number: 12390013; Rumsey, Judith M. 1,2; Affiliation:  1: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland.  2: Child Development Center, Georgetown University Medical  Center, Washington, DC.; Source Info: 1996, Vol. 2 Issue 1, p28; Subject Term: DYSLEXIA; Subject Term: DEVELOPMENTAL disabilities; Subject Term: LANGUAGE disorders; Subject Term: NEUROANATOMY; Subject Term: EMISSION tomography; Subject Term: IMAGING systems in medicine; Author-Supplied Keyword: dyslexia; Author-Supplied Keyword: neuroimaging; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Weisberg, Robert A.
AU  - Freundlich, Martin
AU  - Friedman, David
AU  - Gardner, Jeffrey
AU  - Goosen, Nora
AU  - Nash, Howard
AU  - Oppenheim, Amos
AU  - Rouvière-Yaniv, Josette
T1  - Nomenclature of the genes encoding IHF.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/02//
VL  - 19
IS  - 3
M3  - Letter
SP  - 642
EP  - 642
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - A letter to the editor about the nomenclature of the genes encoding integration host factor is presented.
KW  - Letters to the editor
KW  - Genes
N1  - Accession Number: 21322758; Weisberg, Robert A. 1; Email Address: wia@cu.nih.gov; Freundlich, Martin 2; Friedman, David 3; Gardner, Jeffrey 4; Goosen, Nora 5; Nash, Howard 6; Oppenheim, Amos 7; Rouvière-Yaniv, Josette 8; Affiliations: 1: Building 6B, Room 308, National Institutes of Health, Bethesda, Maryland 20892-0278 USA; 2: Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, USA; 3: Department of Microbiology, University of Michigan, Ann Arbor, Michigan 48109, USA; 4: Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA; 5: Laboratory of Molecular Genetics, Leiden Institute of Chemistry, PO Box 9502, 2300 RA Leiden, The Netherlands; 6: Building 36, Room 1B08, National institutes of Health, Bethesda, Maryland 20892, USA; 7: Department of Molecular Genetics, Hadassah Medical School, POB 12272, Jerusalem 91120, Israel; 8: Institut de Biologie, Physico-Chemique, 13 rue P. et M. Curie, 75005 Paris, France; Issue Info: Feb1996, Vol. 19 Issue 3, p642; Subject Term: Letters to the editor; Subject Term: Genes; Number of Pages: 3/5p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - De luca, Luigi
AU  - Ross, Sharon A.
T1  - Retinoic Acid Response Elements as Positive and Negative Regulators of the Expression of the Homeobox b-1 Gene.
JO  - Nutrition Reviews
JF  - Nutrition Reviews
Y1  - 1996/02//
VL  - 54
IS  - 2
M3  - Article
SP  - 61
EP  - 63
SN  - 00296643
AB  - Retinoic acid-dependent homeobox Hoxb-1 gene expression offers an unanticipated example of both a positive and a negative transcriptional activity of RA, as exerted at different times during embryogenesis. A paradigm for the transduction of positive and negative signaling is the discovery that retinoic acid response elements (RAREs), positioned in the 3′ enhancer and 5′ promoter of the Hoxb-1 gene, may function respectively as positive and negative regulators, thereby permitting a diffused (early positive) as well as a segmentally specified and limited (late negative) expression of the gene. This molecular action of retinoic acid may provide a mechanism for our understanding of normal embryogenesis and of the interference with this process by ectopic retinoic acid, thereby leading to teratogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRETINOIN
KW  - HOMEOBOX genes
KW  - GENE expression
KW  - TERATOGENESIS
KW  - EMBRYOLOGY
KW  - GENETIC transcription -- Regulation
N1  - Accession Number: 26020760; De luca, Luigi 1 Ross, Sharon A. 2; Affiliation:  1: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion National Cancer Institute, Bethesda, MD 20892-4255  2: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion National Cancer Institute, Bethesda, MD 20892-4255.; Source Info: Feb96, Vol. 54 Issue 2, p61; Subject Term: TRETINOIN; Subject Term: HOMEOBOX genes; Subject Term: GENE expression; Subject Term: TERATOGENESIS; Subject Term: EMBRYOLOGY; Subject Term: GENETIC transcription -- Regulation; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107312182
T1  - Retinoic acid response elements as positive and negative regulators of the expression of the homeobox b-1 gene.
AU  - De Luca LM
AU  - Ross SA
Y1  - 1996/02//
N1  - Accession Number: 107312182. Language: English. Entry Date: 19970201. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405. 
KW  - Tretinoin
KW  - Genes
KW  - Fetal Development -- Drug Effects
KW  - Fetal Development
KW  - Teratogens
KW  - Tretinoin -- Physiology
SP  - 61
EP  - 63
JO  - Nutrition Reviews
JF  - Nutrition Reviews
JA  - NUTR REV
VL  - 54
IS  - 2
PB  - Oxford University Press / USA
SN  - 0029-6643
AD  - Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion National Cancer Institute, Bethesda, MD 20892-4255
U2  - PMID: 9053826.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107312182&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107371955
T1  - Wanted: teachers with knowledge of language.
AU  - Moats LC
AU  - Lyons GR
Y1  - 1996/02//
N1  - Accession Number: 107371955. Language: English. Entry Date: 19960601. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; questionnaire/scale; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8201220. 
KW  - Teachers
KW  - Language
KW  - Knowledge
KW  - Education, Continuing (Credit)
KW  - Dyslexia
KW  - Surveys
KW  - Teachers -- Education
SP  - 73
EP  - 98
JO  - Topics in Language Disorders
JF  - Topics in Language Disorders
JA  - TOP LANG DISORD
VL  - 16
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Research on the nature of reading and spelling disability (dyslexia) indicates unequivocally that most dyslexic individuals do not process language accurately or fluently at the level of phonology and that they may experience disorders in syntax and semantics as well. Simultaneously, intervention research clearly demonstrates that individuals who are taught language structure explicitly progress more readily than those who are not. Given the consistency of research findings, the paucity of teachers skilled in teaching language explicitly to dyslexic children is of more concern than ever. Surveys of teacher knowledge, reviews of the literature on teacher education, and policy statements indicate that many teachers are underprepared to teach language content and processes to children whose learning problems are language based. Even motivated and experienced teachers typically understand too little about spoken and written language structure to be able to provide sufficient instruction in these areas. A new approach to teacher education is needed that emphasizes the importance of language knowledge for literacy instruction, as well as its skilled application to instructional planning.
SN  - 0271-8294
AD  - National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2011-03752-007
AN  - 2011-03752-007
AU  - Leidy, Nancy Kline
AU  - Traver, Gayle A
T1  - Adjustment and social behaviour in older adults with chronic obstructive pulmonary disease: The family's perspective.
JF  - Journal of Advanced Nursing
JO  - Journal of Advanced Nursing
JA  - J Adv Nurs
Y1  - 1996/02//
VL  - 23
IS  - 2
SP  - 252
EP  - 259
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0309-2402
SN  - 1365-2648
AD  - Leidy, Nancy Kline, National Institutes of Health, Building 31, Room 5B25, 31 Center Drive, Bethesda, MD, US, 20892-2178
N1  - Accession Number: 2011-03752-007. PMID: 8708236 Partial author list: First Author & Affiliation: Leidy, Nancy Kline; Laboratory for the Study of Human Responses to Health and Illness, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20110411. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Nursing; Quality of Life; Social Adjustment; Social Behavior; Chronic Obstructive Pulmonary Disease. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Sickness Impact Profile. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Feb, 1996. Publication History: Accepted Date: Mar 15, 1995. Copyright Statement: Blackwell Science Ltd. 1996. 
AB  - This study employed secondary data analysis to explore family perceptions of adjustment and social behaviour in older adults (n = 51) with chronic obstructive pulmonary disease (COPD) and their relationship to published norms and patient self-report According to the Katz Adjustment Scale for Relatives, these COPD patients had significantly higher levels of belligerence, negativism, helplessness, withdrawal, psychopathology, nervousness and confusion than reports from relatives of older adults from the general population No differences were found in performance, expectation or dissatisfaction with socially expected activities, or performance of free-time activities However, family members of COPD patients were significantly more dissatisfied with their relative's free-time activities Although family perceptions of socially expected activities corresponded to patient descriptions of general and physical functioning (Sickness Impact Profile), patient perceptions of psychosocial functioning were independent of the family's The results supported the tenet that older adults with COPD have difficulties with adjustment that may adversely affect social relationships, but were not consistent with the belief that the performance of socially expected or free-time activities is more impaired than in others of this age group The data also suggested there may be some perceptual discrepancy between family and patient views of social behaviour. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adjustment & social behavior
KW  - older adults
KW  - chronic obstructive pulmonary disease
KW  - quality of life
KW  - 1996
KW  - Nursing
KW  - Quality of Life
KW  - Social Adjustment
KW  - Social Behavior
KW  - Chronic Obstructive Pulmonary Disease
KW  - 1996
U1  - Sponsor: American Lung Association, US. Recipients: No recipient indicated
DO  - 10.1111/j.1365-2648.1996.tb02664.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38278-007
AN  - 2015-38278-007
AU  - Brooks, P. J.
AU  - Marietta, Cheryl
AU  - Goldman, David
T1  - DNA mismatch repair and DNA methylation in adult brain neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/02//
VL  - 16
IS  - 3
SP  - 939
EP  - 945
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Brooks, P. J., Section on Molecular Neurobiology, Laboratory of Neurogenetics, NIAAA, 12501 Washington Avenue, Rockville, MD, US, 20852
N1  - Accession Number: 2015-38278-007. PMID: 8558262 Partial author list: First Author & Affiliation: Brooks, P. J.; Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Neurons. Minor Descriptor: Mutations; Neoplasms. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 7. Issue Publication Date: Feb, 1996. Publication History: Accepted Date: Oct 31, 1995; Revised Date: Oct 25, 1995; First Submitted Date: Jul 12, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - DNA repair is essential for maintaining the integrity of the nucleotide sequence of cellular DNA over time. Although much information has accumulated recently on the mechanisms of DNA repair in cultured cells, little is known about the DNA repair capabilities of cells in the adult brain. In the present study, we have investigated the capacity of nuclear extracts from adult rodent brain neurons to carry out DNA mismatch repair. We focused on the repair of G.T and G.U mismatches, which are caused by deamination of 5-methyl cytosine to thymine, or cytosine to uracil, respectively, because these are the only types of mismatches that can arise in nondividing cells. We found that nuclear extracts from adult brain neurons can correct G.T and G.U mismatches, restoring them to G:C base pairs. Several other types of DNA mismatches could not be processed. These data provide the first direct demonstration that neurons in the adult mammalian brain have the capability to carry out DNA mismatch repair. We also we report that adult brain contains high levels of DNA methyltransferase (MTase) activity. We propose that one function of DNA MTase in the adult brain is to remethylate newly incorporated cytosine residues from G.T mismatch repair after deamination of 5-methyl cytosine, thereby maintaining the original pattern of DNA methylation. The high levels of brain DNA MTase suggest further that this enzyme has additional functions in the brain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - DNA repair
KW  - DNA methylation
KW  - neurons
KW  - mutation
KW  - cancer
KW  - cell nucleus
KW  - 5-methyl cytosine
KW  - DNA glycosylase
KW  - mismatch repair
KW  - 1996
KW  - Brain
KW  - Neurons
KW  - Mutations
KW  - Neoplasms
KW  - 1996
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38278-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38278-008
AN  - 2015-38278-008
AU  - Kidd, Grahame
AU  - Andrews, S. Brian
AU  - Trapp, Bruce D.
T1  - Axons regulate the distribution of Schwann cell microtubules.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/02//
VL  - 16
IS  - 3
SP  - 946
EP  - 954
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Trapp, Bruce D., Department of Neurosciences, Cleveland Clinic Foundation, NC30, 9500 Euclid Avenue, Cleveland, OH, US, 44195
N1  - Accession Number: 2015-38278-008. PMID: 8558263 Partial author list: First Author & Affiliation: Kidd, Grahame; Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Kidd, Grahame. Major Descriptor: Axons; Schwann Cells. Minor Descriptor: Cytoplasm; Neurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: Feb, 1996. Publication History: Accepted Date: Nov 1, 1995; Revised Date: Oct 3, 1995; First Submitted Date: Jun 30, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - It is well established that axons regulate Schwann cell phenotype. The purpose of the present study was to determine whether axons influence the arrangement of Schwann cell microtubules (MTs). Using double-labeling immunocytochemistry and confocal microscopy, we show that MTs in undifferentiated Schwann cells are nucleated from and attached to a single MT organizing center (MTOC) that is associated with the centrosome. Physical contact with appropriate axons initiates a myelin-forming phenotype that disperses MT minus ends and induces multiple MT-nucleating sites in Schwann cell perinuclear cytoplasm. The axonal signal that initiates myelin breakdown during Wallerian degeneration induces multiple MTOCs and MT bundles in Schwann cell perinuclear cytoplasm and in cytoplasm between degenerating myelin ovoids. These results establish that axons influence Schwann cell MT distribution by regulating the location and number of MT-nucleation sites. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - axonal signaling
KW  - microtubules
KW  - MTOC
KW  - myelination
KW  - Schwann cell
KW  - Wallerian degeneration
KW  - 1996
KW  - Axons
KW  - Schwann Cells
KW  - Cytoplasm
KW  - Neurons
KW  - 1996
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, US. Grant: NS22849; NS29818. Recipients: No recipient indicated
U1  - Sponsor: National Multiple Sclerosis Society. Other Details: Postdoctoral Fellowship. Recipients: Kidd, Grahame
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107266718
T1  - Evaluating new vaccines for developing countries. Efficacy or effectiveness?
AU  - Clemens J
AU  - Brenner R
AU  - Rao M
AU  - Tafari N
AU  - Lowe C
AU  - Clemens, J
AU  - Brenner, R
AU  - Rao, M
AU  - Tafari, N
AU  - Lowe, C
Y1  - 1996/02/07/
N1  - Accession Number: 107266718. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Vaccines
KW  - Clinical Trials
KW  - Immunization -- Developing Countries
KW  - Drugs, Investigational
KW  - Communicable Diseases -- Prevention and Control -- Developing Countries
KW  - Developing Countries
KW  - Vaccines -- Economics
KW  - Immunization -- Economics
KW  - Study Design
KW  - Health Policy
SP  - 390
EP  - 397
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 275
IS  - 5
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Despite the profusion of promising new vaccines against illnesses prevalent in developing countries, uncertainties about the balance between costs and benefits of new vaccines have retarded their use in public health practice. Conventional prelicensure trials of vaccine protection exacerbate these uncertainties by focusing on measurement of vaccine efficacy--the performance of a vaccine under idealized conditions. Vaccine effectiveness trials provide a more pragmatic perspective by addressing the performance of a vaccine under the ordinary conditions of a public health program, by capturing direct as well as indirect effects of vaccination, and by comprehensively addressing outcomes of public health concern. The use of effectiveness trials should enable more rational triaging of new vaccines for developing countries and may accelerate the introduction of new vaccines into public health practice by resolving speculative debates about practical costs and benefits.
SN  - 0098-7484
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Md
U2  - PMID: 8569019.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107251237
T1  - Subtypes of alcoholics based on psychometric measures.
AU  - Allen JP
Y1  - 1996/03//
N1  - Accession Number: 107251237. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Personality Research Form (PRF); University of Rhode Island Change Assessment Scale (URICA) (McConnaughy et al); Millon Clinical Multiaxial Inventory (MCMI); Minnesota Multiphasic Personality Inventory (MMPI). NLM UID: 0365245. 
KW  - Alcoholism -- Diagnosis
KW  - Alcoholism -- Classification
KW  - Psychometrics
KW  - Psychological Tests
KW  - Personality
KW  - Personality Tests
KW  - MMPI
KW  - Motivation
SP  - 24
EP  - 29
JO  - Alcohol Health & Research World
JF  - Alcohol Health & Research World
JA  - ALCOHOL HEALTH RES WORLD
VL  - 20
IS  - 1
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - One approach to subtyping alcoholics is the use of psychometric tests that quantify a person's personality characteristics, psychological characteristics, and intelligence. For example, researchers have used the Personality Research Form, which measures basic personality traits, to establish alcoholism typologies. Other psychometric measures that have been employed in the classification of alcoholics, such as the Minnesota Multiphasic Personality inventory and the Millon Clinical Multiaxial Inventory, measure the presence of co-occurring psychiatric disorders in the patients. Still other subtypes are based on tests assessing the patient's motivation for treatment. Although clinicians hope to use psychometric typologies to improve treatment planning and monitoring for their patients, several questions remain to be answered by additional research before the instruments and the typologies based on them achieve broad applicability.
SN  - 0090-838X
AD  - Chief, Treatment Research Branch, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107251274
T1  - NIAAA's epidemiologic bulletin no. 36. Comorbidity between DSM-IV alcoholic and drug use disorders.
AU  - Grant BF
AU  - Pickering RP
Y1  - 1996/03//
N1  - Accession Number: 107251274. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; glossary; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0365245. 
KW  - Substance Abuse
KW  - Alcoholism
KW  - Comorbidity
KW  - Epidemiological Research
KW  - DSM
KW  - Fieldwork
KW  - Prospective Studies
KW  - Interviews
KW  - Adult
KW  - Stratified Random Sample
KW  - Data Analysis Software
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Logistic Regression
KW  - Statistical Significance
KW  - Prevalence
KW  - Cluster Sample
KW  - United States
KW  - Human
SP  - 67
EP  - 72
JO  - Alcohol Health & Research World
JF  - Alcohol Health & Research World
JA  - ALCOHOL HEALTH RES WORLD
VL  - 20
IS  - 1
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - Research has not yet determined the answers to many questions regarding the comorbidity of alcohol and drug use disorders. Past studies often have not distinguished abuse from dependence and use and have not made diagnoses according to psychiatric classifications. This study relies on data from the 1992 National Longitudinal Alcohol Epidemiologic Survey, which attempts to address these concerns. The study demonstrates a pervasive co-occurrence of alcohol and drug use disorders in the general population. Further, the comorbidity of alcohol and drug dependence is found to be significantly greater than the comorbidity of alcohol and drug abuse.
SN  - 0090-838X
AD  - Chief, Biometry Branch, Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105649823
T1  - Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis.
AU  - Talar-Williams C
AU  - Hijazi YM
AU  - Walther MM
AU  - Linehan WM
AU  - Hallahan CW
AU  - Lubensky I
AU  - Kerr GS
AU  - Hoffman GS
AU  - Fauci AS
AU  - Sneller MC
Y1  - 1996/03//3/1/96
N1  - Accession Number: 105649823. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Bladder Neoplasms -- Chemically Induced
KW  - Carcinoma -- Chemically Induced
KW  - Cyclophosphamide -- Adverse Effects
KW  - Cystitis -- Chemically Induced
KW  - Wegener's Granulomatosis -- Drug Therapy
KW  - Aged
KW  - Aged, 80 and Over
KW  - Cox Proportional Hazards Model
KW  - Female
KW  - Hematuria -- Chemically Induced
KW  - Male
KW  - Middle Age
KW  - Regression
KW  - Retrospective Design
KW  - Risk Factors
KW  - Urine
KW  - Human
SP  - 477
EP  - 484
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 124
IS  - 5
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
AB  - OBJECTIVE: To describe the incidence of, clinical manifestations of, and risk factors for cyclophosphamide-induced urinary bladder toxicity in patients treated for nonmalignant disease. DESIGN: Retrospective analysis of patients followed at the National Institutes of Allergy and Infectious Diseases from 1967 to 1993. SETTING: The Warren G. Magnuson Clinical Center of the National Institutes of Health (NIH). PATIENTS: 145 patients who received cyclophosphamide for the treatment of Wegener granulomatosis and were followed for 0.5 to 27 years (median, 8.5 years), for a total of 1333 patient-years. MEASUREMENTS: Clinical characteristics, cystoscopic findings, results of cytologic examination of urine, surgical pathology, and total dose and duration of cyclophosphamide therapy were recorded and analyzed using a computer-based information retrieval system. RESULTS: Nonglomerular hematuria occurred in 73 of 145 patients treated with cyclophosphamide (50%). Sixty of the 73 patients with nonglomerular hematuria (82%) had cystoscopy at the NIH. Forty-two of the 60 patients (70%) who had cystoscopy had macroscopic changes consistent with cyclophosphamide-induced bladder injury. Seven patients (5%) developed transitional-cell carcinoma of the urinary bladder. In 6 of these 7 patients, the total cumulative cyclophosphamide dose exceeded 100 g, and the cumulative duration of cyclophosphamide therapy exceeded 2.7 years. Before they were given a diagnosis of bladder cancer, all 7 patients had had one or more episodes of microscopic or gross nonglomerular hematuria. In contrast, none of the 72 patients who had never had nonglomerular hematuria developed bladder cancer. Cox proportional hazards regression analysis showed that only microscopic nonglomerular hematuria was a significant risk factor for the development of bladder cancer (P < 0.01). CONCLUSION: Long-term oral cyclophosphamide therapy is associated with substantial urotoxicity, including the development of transitional-cell carcinoma of the urinary bladder. In this cohort of patients, the estimated incidence of bladder cancer after the first exposure to cyclophosphamide was 5% at 10 years and 16% at 15 years. Nonglomerular hematuria was a frequent manifestation of cyclophosphamide-induced cystitis, and it identified a subgroup of patients at high risk for the development of bladder cancer.
SN  - 0003-4819
AD  - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 8602705.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107362270
T1  - Relation of sociodemographic, clinical, and quality-of-life variables to adherence in the Cardiac Arrhythmia Suppression Trial.
AU  - Schron EB
AU  - Brooks MM
AU  - Gorkin L
AU  - Kellen JC
AU  - Morris M
AU  - Campion J
AU  - Shumaker SA
AU  - Corum J
Y1  - 1996/03//1996 Mar-Apr
N1  - Accession Number: 107362270. Language: English. Entry Date: 19960301. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 0004704. 
KW  - Research Subjects
KW  - Patient Compliance
KW  - Arrhythmia -- Drug Therapy
KW  - Quality of Life
KW  - Clinical Trials
KW  - Random Assignment
KW  - Odds Ratio
KW  - Logistic Regression
KW  - Cardiac Patients
KW  - Socioeconomic Factors
KW  - Questionnaires
KW  - Repeated Measures
KW  - Myocardial Infarction
KW  - Chi Square Test
KW  - Descriptive Statistics
KW  - Age Factors
KW  - Educational Status
KW  - Male
KW  - Female
KW  - Human
SP  - 1
EP  - 5
JO  - Cardiovascular Nursing
JF  - Cardiovascular Nursing
JA  - CARDIOVASC NURS
VL  - 32
IS  - 2
CY  - Dallas, Texas
PB  - American Heart Association
SN  - 0008-6355
AD  - National Heart, Lung, and Blood Institute, Bethesda, Maryland
U2  - PMID: 8697488.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107368460
T1  - Merging PICU and MICU: expanding nurse competencies.
AU  - Clarke DL
AU  - Coghill K
AU  - Dominguez D
AU  - Smatlak P
AU  - Johnson S
AU  - Kozma-Fornaro MJ
Y1  - 1996/03//1996 Mar-Apr
N1  - Accession Number: 107368460. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Commentary: Clinical competency: part of the merger process. (PERIANESTH AMBULATORY SURG NURS UPDATE) 1996 Jul; 4 (4): 63-64. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8211489. 
KW  - Intensive Care Units, Pediatric
KW  - Intensive Care Units
KW  - Multiskilled Health Practitioners
KW  - Education, Competency-Based
KW  - Collaboration
KW  - Critical Care Nursing
KW  - Pediatric Critical Care Nursing
KW  - Staff Development
KW  - Change Management
KW  - Hospitals, Special -- Maryland
KW  - Maryland
KW  - Budgets
SP  - 106
EP  - 112
JO  - Dimensions of Critical Care Nursing
JF  - Dimensions of Critical Care Nursing
JA  - DCCN
VL  - 15
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Unit mergers offer an opportunity for nurses to acquire additional skills. A model for unit mergers is presented. The authors describe how didactic and clinical competencies serve as a foundation upon which the nurse develops proficiency and expertise in a new subspecialty.
SN  - 0730-4625
AD  - National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8697945.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Maffioli, Lorenzo
AU  - Gasparini, Massimo
AU  - Chiti, Arturo
AU  - Gramaglia, Alberto
AU  - Mongioj, Valeria
AU  - Pozzi, Annalisa
AU  - Bombardieri, Emilio
T1  - Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1996/03//
VL  - 23
IS  - 3
M3  - Article
SP  - 308
EP  - 311
SN  - 03406997
N1  - Accession Number: 71154730; Maffioli, Lorenzo 1 Gasparini, Massimo 1 Chiti, Arturo 1 Gramaglia, Alberto 2 Mongioj, Valeria 3 Pozzi, Annalisa 4 Bombardieri, Emilio 1; Affiliation:  1: Department of Nuclear Medicine, National Cancer Institute, Milan Italy  2: Division of Radiotherapy, National Cancer Institute, Milan Italy  3: Division of Health Physics, National Cancer Institute, Milan Italy  4: Division of Neuro-oncology, 'C.Besta' National Neurological Institute, Milan Italy; Source Info: Mar1996, Vol. 23 Issue 3, p308; Number of Pages: 4p; Document Type: Article
L3  - 10.1007/BF00837629
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - IRWIN, RICHARD D.
AU  - CHHABRA, RAJENDRA
AU  - EUSTIS, SCOTT
AU  - PINTER, ALAN
AU  - PREJEAN, J. D.
T1  - Tumors of the Bladder, Kidney, and Intestine of F344 Rats and Liver of B6C3F1 Mice Administered o-Nitroanisole in Feed.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/03//
VL  - 30
IS  - 1
M3  - Article
SP  - 1
EP  - 12
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Tumors of the Bladder, Kidney, and Intestine of F344 Rats and Liver of B6C3F1 Mice Administered o-Nitroanisole in Feed. IRWIN, R. D., CHHABRA, R., EUSTIS, S., PINTER, A., AND PREJEAN, J. D. 1996). Fundam. Appl. Toxicol. 30, 1–12.o-Nitroanisole, a mutagenic intermediate used in the manufacture of azo dyes, was administered in feed for 2 years at concentrations of 0, 222, 666, or 2000 ppm to groups of 60 male and 60 female F344 rats. No significant increase in neoplasms occurred in these groups of rats. Additional (stop exposure) groups of 60 male and 60 female F344 rats received diets containing 0, 6000, or 18,000 ppm for 27 weeks followed by maintenance on control diets for up to an additional 77 weeks. Survival of the stop exposure groups was reduced because of the development of chemical related neoplasms of the urinary bladder. After 13, 28, 40, and 65 weeks on study, 10 rats per group were necropsied and evaluated for the presence of chemical associated lesions. Hyperplasia of the epithelium of the urinary bladder was significantly increased at all interim evaluations. A transitional cell carcinoma was observed at the 13-week evaluation in one male rat that received 18,000 ppm and thereafter transitional cell neoplasms of the bladder were present in male and female rats at each interim evaluation. Adeno matous polyps of the large intestine were significantly increased in groups that received 6000 or 18,000 ppm. In addition carcino mas of the large intestine were present in four males and two females that received 18,000 ppm. Hyperplasia of the transitional epithelium of the renal pelvis was significantly increased in groups of rats that received 6000 or 18,000 ppm and transitional cell papillomas were observed in three males and one female that received 18,000 ppm. Transitional cell carcinomas of the kidney occurred in one male that received 6000 ppm and six males and one female that received 18,000. Groups of 60 male and 60 female B6C3F1, mice received dietary concentrations of 0, 666, 2000, or 6000 ppm o-nitroanisole for 2 years. No stop exposure study was conducted with mice. The only neoplastic response observed in mice was in the liver of males; hepatocellular adenomas or carcino mas were increased in groups of male mice that received 2000 or 6000 ppm. No increase in neoplasms associated with chemical exposure occurred in female mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutagens
KW  - Bladder -- Tumors
KW  - Kidney tumors
KW  - Intestines -- Tumors
KW  - Rats as laboratory animals
KW  - Nitroanisoles
KW  - Azo dyes
N1  - Accession Number: 82419664; IRWIN, RICHARD D. 1; CHHABRA, RAJENDRA 1; EUSTIS, SCOTT 1; PINTER, ALAN 2; PREJEAN, J. D. 3; Affiliations: 1: National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 12233; 2: † National Institute of Hygiene Budapest, Hungary; 3: ‡ Southern Research Institute Birmingham, Alabama; Issue Info: 1996, Vol. 30 Issue 1, p1; Thesaurus Term: Mutagens; Subject Term: Bladder -- Tumors; Subject Term: Kidney tumors; Subject Term: Intestines -- Tumors; Subject Term: Rats as laboratory animals; Subject Term: Nitroanisoles; Subject Term: Azo dyes; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - TRAVLOS, G. S.
AU  - MAHLER, J.
AU  - RAGAN, H. A.
AU  - CHOU, B. J.
AU  - BUCHER, J. R.
T1  - Thirteen-Week Inhalation Toxicity of 2- and 4-Chloronitrobenzene in F344/N Rats and B6C3F1 Mice.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/03//
VL  - 30
IS  - 1
M3  - Article
SP  - 75
EP  - 92
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Toxicity studies were performed by exposing F344/N rats and B6C3F1 mice to 2- and 4-chloronitrobenzene (CNB) by whole body inhalation 6 hr/day, 5 days/week, for 13 weeks. Animals were evaluated for clinical chemistry (rats), hematology (rats), histopathology, and body/organ weights. Exposure concentrations were 0, 1.1, 2.3, 4.5, 9, and 18 ppm for 2-CNB and 0, 1.5, 3, 6, 12, and 24 ppm for 4-CNB. All rats in the 2-CNB study survived until the end of the study. Two male mice in the 18-ppm group in the 2-CNB study, however, died during Week 12; no deaths attributable to 4-CNB exposure occurred in rats or mice. In both studies, the mean body weight gains of exposed animals were similar to those of the respective controls. In rats, inhalation exposure to 2- or 4-CNB resulted in methemoglobinemia leading to a regenerative anemia and a variety of tissue changes secondary to the oxidative erythrocyte injury. In the 2-CNB study, methemoglobinemia resulted in a normocytic, normochiomic, responsive anemia, whereas with 4-CNB, the methemoglobinemia was more severe and resulted in a niacrocytic, hyperchromic, responsive anemia. Alterations of erythrocyte morphology were observed in both studies; changes included Heinz bodies, poikilocytes, and polychromasia. In rats, both isomers caused increases in serum activities of alanine aminotransferase and sorbitol dehydrogenase and increased bile acid concentrations. Microscopic liver changes included hemosiderin deposition in Kupffer cells (rats and mice exposed to 4-CNB), hepatocytomegaly (mice), and cytoplasmic basophilia (rats). Hepatocellular necrosis and chronic inflammation observed in mice were rather specific to the 2-CNB isomer, as only slight evidence of focal necrosis in the liver was observed in mice exposed to 4-CNB. Splenic lesions included hemosiderin accumulation, capsular fibrosis, and increased hematopoietic cell proliferation. Increased bone marrow hemosiderin and hematopoietic cell proliferation and kidney tubule hemosiderin deposition were also observed. Other findings, attributed to chemical exposure but not to the hematotoxicity, were described. Lesions included hyaline droplet nephropathy and degeneration of the testis in male rats exposed to 4-CNB, inflammation of the harderian gland in rats exposed to 4-CNB, hyperplasia of the nasal cavity epithelium in rats exposed to 2-CNB, and hyperplasia of the forestomach epithelium in mice exposed to 4-CNB; these lesions have not been described previously in studies with these chemicals. Based on the exposure concentrations evaluated, A no-observed-adverse-effect level (NOAEL) for histopathological injury in mice was 4.5 ppm for 2-chloronitrobenzene and 6 ppm for 4-chloronitrobenzene; a NOAEL was not determined for rats. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Chloronitrobenzenes
KW  - Rats as laboratory animals
KW  - Hematology
KW  - Methemoglobinemia
KW  - Erythrocytes
KW  - Necrosis
KW  - Cell proliferation
N1  - Accession Number: 82419677; TRAVLOS, G. S. 1; MAHLER, J. 1; RAGAN, H. A. 2; CHOU, B. J. 2; BUCHER, J. R. 1; Affiliations: 1: National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; 2: † Battelle Pacific Northwest Laboratories Battelle Boulevard, Richland, Washington 99352; Issue Info: 1996, Vol. 30 Issue 1, p75; Thesaurus Term: Chloronitrobenzenes; Subject Term: Rats as laboratory animals; Subject Term: Hematology; Subject Term: Methemoglobinemia; Subject Term: Erythrocytes; Subject Term: Necrosis; Subject Term: Cell proliferation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 18p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - CHAN, P. C.
AU  - SILLS, R. C.
AU  - BRAUN, A. G.
AU  - HASEMAN, J. K.
AU  - BUCHER, J. R.
T1  - Toxicity and Carcinogenicity of Δ9-Tetrahydrocannabinol in Fischer Rats and B6C3F1 Mice.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/03//
VL  - 30
IS  - 1
M3  - Article
SP  - 109
EP  - 117
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Δ9-Tetrahydrocannabinol (Δ9-THC) was studied for potential carcinogenicity in rodents because it is the principal psychoactive ingredient in marihuana and it has potential medicinal uses. Δ9-THC in corn oil was administered by gavage to groups of male and female Fischer rats and B6C3F1 mice at 0, 5, 15, 50, 150, or 500 mg/kg, 5 days a week for 13 weeks and for 13-week plus a 9-week recovery period, and to groups of rats at 0, 12.5, 25, or 50 mg/kg and mice at 0, 125, 250, or 500 mg/kg, 5 times a week for 2 years. In all studies, mean body weights of dosed male and female rats and mice were lower than controls but feed consumptions were similar. Convulsions and hyperactivity were observed in dosed rats and mice; the onset and frequency were dose related. Serum FSH and LH levels hi all dosed male rats and corticosterone levels in 25 mg/kg female rats were significantly higher than controls at 15 months in the 2-year studies. Δ9-THC administration for 13 weeks induced testicular atrophy and uterine and ovarian hypoplasia; the lesions persisted in a 9-week recovery period. In the 2-year studies, survival of dosed rats was higher than controls; that of mice was similar to controls. Incidences of testicular interstitial cell, pancreas and pituitary gland adenomas in male rats, mammary gland fibroadenoma and uterus stromal polyp in female rats, and hepatocellular adenoma/carcinoma in male and female mice were reduced in a dose-related manner. Decreased tumor incidences may be at least in part due to reduced body weights of dosed animals. Incidences of thyroid gland follicular cell hyperplasia were increased in all dosed groups of male and female mice, and follicular cell adenomas were significantly increased in the 125 mg/kg group of males, but there was no evidence of a dose-related trend in proliferative lesions of the thyroid. There was no evidence that Δ9-THC was carcinogenic in rats or mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogenicity
KW  - Carcinogenesis -- Animal models
KW  - Tetrahydrocannabinol
KW  - Rats as laboratory animals
KW  - Convulsions
N1  - Accession Number: 82419666; CHAN, P. C. 1; SILLS, R. C. 1; BRAUN, A. G. 2; HASEMAN, J. K. 1; BUCHER, J. R. 1; Affiliations: 1: National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; 2: † The TSI Mason Research Institute Worcester, Massachusetts 01608; Issue Info: 1996, Vol. 30 Issue 1, p109; Thesaurus Term: Carcinogenicity; Subject Term: Carcinogenesis -- Animal models; Subject Term: Tetrahydrocannabinol; Subject Term: Rats as laboratory animals; Subject Term: Convulsions; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Giese, N. A.
AU  - Gazzinelli, R. T.
AU  - Actor, J. K.
AU  - Morawetz, R. A.
AU  - Sarzotti, M.
AU  - Morse III, H. C.
T1  - Retrovirus-elicited interleukin-12 and tumour necrosis factor-α as inducers of interferon-γ-mediated pathology in mouse AIDS.
JO  - Immunology
JF  - Immunology
Y1  - 1996/03//
VL  - 87
IS  - 3
M3  - Article
SP  - 467
EP  - 474
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Spleen cells from mice resistant or sensitive to mouse acquired immune deficiency syndrome (MAIDS) were examined for cytokine mRNA. In MAIDS-resistant BALB/c mice, cytokine transcripts peaked at 1 week after infection with Type 1 cytokines [interleukin-2 (IL-2), turnout necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IL-12], dominating over Type 2 cytokines (IL-4, IL-10). Expression of cytokines other than IL-2 later declined to levels seen in uninfected mice. In MAIDS-sensitive B6 mice, transcripts for all cytokines were increased at 1 week and, except for IL-2, increased progressively. Spontaneous production of IFN-γ protein was associated with enhanced mRNA expression at 1 week after infection of either strain, but none was detectable in association with even higher levels of transcripts at later times after infection of B6 mice. Spleen cells from longer-term-infected B6 mice, however, produced substantial amounts of IFN-γ following treatment with lipopolysaccharide (LPS) or IL-12. Inclusion of anti-IL-12 or anti- TNF-α antibodies blocked induction of IFN-γ by LPS. Induction of IFN-γ by IL-12 was potentiated by TNF-α following stimulation of intact spleen cells and purified CD4+ or CD8+ T cells, as well as negatively selected CD4-8- cells from infected B6 mice. Further studies showed that IFN-γ knockout mice on a B6 background developed MAIDS with a prolonged time-course, whereas BALB/c knockout mice were unchanged in their resistance to MAIDS. These studies suggest that continuing low-level expression of IFN-γ stimulated by IL-12 and TNF-α contributes to the susceptibility of B6 mice to MAIDS but is not required for the resistance of BALB/c mice to disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease)
KW  - MICE as laboratory animals
KW  - INTERLEUKIN-12
KW  - TUMOR necrosis factor
KW  - INTERFERONS
KW  - RETROVIRUSES
KW  - IMMUNOLOGY
N1  - Accession Number: 14086405; Giese, N. A. 1 Gazzinelli, R. T. 2 Actor, J. K. 2 Morawetz, R. A. 1 Sarzotti, M. 3 Morse III, H. C. 1; Affiliation:  1: Laboratory of Immunopathology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD  2: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD  3: Veterans Administration Medical Center, Baltimore, MD, USA; Source Info: Mar96, Vol. 87 Issue 3, p467; Subject Term: AIDS (Disease); Subject Term: MICE as laboratory animals; Subject Term: INTERLEUKIN-12; Subject Term: TUMOR necrosis factor; Subject Term: INTERFERONS; Subject Term: RETROVIRUSES; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chipev, Constantin C.
AU  - Steinert, Peter M.
AU  - Woodworth, Craig D.
T1  - Characterization of an Immortalized Cell Line from a Patient with Epidermolytic Hyperkeratosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/03//
VL  - 106
IS  - 3
M3  - Article
SP  - 385
EP  - 390
SN  - 0022202X
AB  - The most frequent mutation that causes the autosomal dominant skin disease epidermolytic hyperkeratosis (EHK) is an arginine to histidine substitution at position 10 in the 1A segment of the rod domain of keratin 10. As an initial step toward developing a strategy for treating EHK, a cell line, EH18-1, was established after keratinocytes derived from an EHK patient with this mutation were immortalized by a recombinant retrovirus encoding the E6 and E7 genes of human papillomavirus type 18. EH18-1 cells synthesize considerable amounts of keratin 10 mRNA and protein when maintained in either submerged cultures or in organotypic cultures. `When grown in organotypic culture, EH18-1 cells form multiple layers and express keratin 10 and filaggrin predominantly in the upper layers. Thus, the EH18-1 cell line exhibits several morphological and biochemical markers of tenninal epidermal differentiation. A sentiquantitative reverse transcriptase polymerase chain reaction assay for keratin 10 mRNA was developed to distinguish between expression of the normal and the mutant alleles. The EH18-1 keratinocyte cell line will be useful in developing protocols for gene therapy of ENK that may be monitored by reverse transcriptase polymerase chain reaction of either allele. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POLYMERASE chain reaction
KW  - IMMUNOHISTOCHEMISTRY
KW  - KERATIN
KW  - SKIN diseases
KW  - CELL lines
KW  - PAPILLOMAVIRUSES
KW  - <em>Arg to His mutation</em>
KW  - <em>immunohistochemistry</em>
KW  - <em>keratin 10.</em>
KW  - <em>RT-PCR allele specific assay</em>
KW  - <em>submerged and organotypic cultures</em>
N1  - Accession Number: 12343322; Chipev, Constantin C. 1 Steinert, Peter M. 1 Woodworth, Craig D. 2; Affiliation:  1: Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, U.S.A.  2: Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1996, Vol. 106 Issue 3, p385; Subject Term: POLYMERASE chain reaction; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: KERATIN; Subject Term: SKIN diseases; Subject Term: CELL lines; Subject Term: PAPILLOMAVIRUSES; Author-Supplied Keyword: <em>Arg to His mutation</em>; Author-Supplied Keyword: <em>immunohistochemistry</em>; Author-Supplied Keyword: <em>keratin 10.</em>; Author-Supplied Keyword: <em>RT-PCR allele specific assay</em>; Author-Supplied Keyword: <em>submerged and organotypic cultures</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12343322
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanwell, Caroline
AU  - Denning, Mitchell F.
AU  - Rutberg, Susan E.
AU  - Cheng, Christina
AU  - Yuspa, Stuart H.
AU  - Dlugosz, Andrzej A.
T1  - Staurosporine Induces a Sequential Program of Mouse Keratinocyte Terminal Differentiation through Activation of PKC Isozymes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/03//
VL  - 106
IS  - 3
M3  - Article
SP  - 482
EP  - 489
SN  - 0022202X
AB  - Staurosporine (stsp) induces assembly of cornified envelopes in mouse keratinocyte cultures. To clarify whether this effect is the consequence of a coordinated differentiation program similar to that observed in epidermis, we assessed the expression of multiple differentiation-specific markers in stsp-treated keratinocytes. In medium containing 0.05 mM Ca&sup2+; in which the basal cell phenotype is normally maintained, stsp induced dose-dependent increases in keratin 1, epidermal and keratinocyte transglutaminases, SPR-1, loricrin, and profilaggrin mRNA. Based on nuclear run-on analysis, stsp-mediated marker expression was found to be due at least in part to increased transcription. Since protein kinase C (PKC) activation is required for keratinocyte differentiation, we tested whether stsp influenced this signaling pathway. Stsp induced the translocation of multiple PKC isoforms from the cytosol to membrane and/or cytoskeletal fractions, inducing isozyme downregulation within 24 h. Moreover, AP-1 DNA binding activity was elevated in stsp-treated keratinocytes, consistent with the notion that this agent influences keratinocyte-specific gene expression via the PKC pathway. Stsp-mediated marker expression was inhibited by the PKC inhibitor GF 109203X. In cells pre-treated with bryostatin 1 to selectively down-modulate specific PKC isoforms, stsp-induced loricrin, filaggrin, and SPR-1 expression was suppressed when PKC α, &epsiv;, and/or δ were downregulated, suggesting that these isozymes may be necessary for marker expression in response to this agent. Thus, in addition to its effects on cornified envelope assembly, stsp induces a coordinate program of differentiation-specific keratinocyte gene expression that is mediated at least in part by the PKC signaling pathway. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATINOCYTES
KW  - PROTEIN kinases
KW  - EPIDERMIS
KW  - TRANSGLUTAMINASES
KW  - MESSENGER RNA
KW  - GENE expression
KW  - <em>keratinocytes</em>
KW  - <em>protein kinase C</em>
KW  - <em>stanrosporine.</em>
N1  - Accession Number: 12343690; Stanwell, Caroline 1 Denning, Mitchell F. 2 Rutberg, Susan E. 1 Cheng, Christina Yuspa, Stuart H. 1 Dlugosz, Andrzej A. 3; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Northwestern University Medical School, Department of Pathology W127, 303 E. Chicago Avenue, Chicago IL 60611-3008.  3: Laboratory of Tumor Virus Biology, National Cancer Institute, Building 41/ Room D824, 41 Library Drive MSC 5055, Bethesda, MD 20892-5055.; Source Info: Mar1996, Vol. 106 Issue 3, p482; Subject Term: KERATINOCYTES; Subject Term: PROTEIN kinases; Subject Term: EPIDERMIS; Subject Term: TRANSGLUTAMINASES; Subject Term: MESSENGER RNA; Subject Term: GENE expression; Author-Supplied Keyword: <em>keratinocytes</em>; Author-Supplied Keyword: <em>protein kinase C</em>; Author-Supplied Keyword: <em>stanrosporine.</em>; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12343690
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schwarzenberger, Kathryn
AU  - Udey, Mark C.
T1  - Contact Allergens and Epidermal Proinflammatory Cytokines Modulate Langerhans Cell E-cadherin Expression <em>in Situ</em>.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/03//
VL  - 106
IS  - 3
M3  - Article
SP  - 553
EP  - 558
SN  - 0022202X
AB  - After exposure to antigen, Langerhans cells (LC) migrate from the epidermis to lymph nodes, where they initiate primary immune responses in T cells. The adhesion molecule E-cadherin mediates adhesion of LC to keratinocytes <em>in vitro</em> and may be responsible for localization of LC in epidermis. To determine if levels of LC E-cadherin are modulated during LC emigration from epidermis, we utilized flow cytometry to evaluate E-cadherin expression on BALB/c LC exposed <em>in situ</em> to the contact allergen 2,4,6-trinitrochlorobenzene (TNCB). TNCB induced increased I-A/E antigen and decreased E-cadherin expression on a subpopulation of LC as early as 12 h, and as late as 48 h, after application. At 24 h, ∼30% of LC in TNCB-treated skin expressed increased I-A/E antigens; of these activated LC, -∼40% expressed decreased levels of E-cadherin. E-cadherin levels on this latter subset were ∼15% of those expressed by LC in normal skin, and were similar to levels on cultured LC and LC that migrated from skin explants. The effect was specific for allergens; no changes occurred in LC following treatment with several contact irritants or the tolerogen dinitrothiocyanobenzene. To determine if cytokines modulated LC E-cadherin expression, we introduced various cytokines into BALB/c ear skin and assayed I-AlE antigen and E-cadherin levels. Of the cytokines tested, only interleukin-1 and tumor necrosis factor a reproduced the effects of TNCB. We propose that downmodulation of E-cadherin expression occurs as a consequence of local cytokine production during antigen-induced LC activation, facilitating LC emigration and the initiation of immune responses against antigens encountered in epidermis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUCOCYTES
KW  - CELL adhesion
KW  - LANGERHANS cells
KW  - EPIDERMIS
KW  - IMMUNE response
KW  - T cells
KW  - KERATINOCYTES
KW  - <em>activation</em>
KW  - <em>adhesion</em>
KW  - <em>leukocyte</em>
KW  - <em>migration.</em>
N1  - Accession Number: 12344019; Schwarzenberger, Kathryn Udey, Mark C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1996, Vol. 106 Issue 3, p553; Subject Term: LEUCOCYTES; Subject Term: CELL adhesion; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: KERATINOCYTES; Author-Supplied Keyword: <em>activation</em>; Author-Supplied Keyword: <em>adhesion</em>; Author-Supplied Keyword: <em>leukocyte</em>; Author-Supplied Keyword: <em>migration.</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12344019
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, R.
AU  - Zonderman, Alan B.
AU  - Costa Jr., Paul T.
AU  - Bond, Michael H.
AU  - Paunonen, Sampo V.
T1  - Evaluating Replicability of Factors in the Revised NEO Personality Inventory: Confirmatory factor Analysis Versus Procrustes Rotation.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1996/03//
VL  - 70
IS  - 3
M3  - Article
SP  - 552
EP  - 566
SN  - 00223514
AB  - Despite the empirical robustness of the 5-factor model of personality, recent confirmatory factor analyses (CFAs) of NEO Personality Inventory (NEO-PI) data suggest they do not fit the hypothesized model. In a replication study of 229 adults, a series of CFAs showed that Revised NEO-PI scales are not simple-structured but do approximate the normative 5-factor structure. CFA goodness-of-fit indices, however, were not high. Comparability analyses showed that no more than 5 factors were replicable, which calls into question some assumptions underlying the use of CFA. An alternative method that uses targeted rotation was presented and illustrated with data from Chinese and Japanese versions of the Revised NEO-PI that clearly replicated the 5-factor structure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - PSYCHOLOGY
KW  - FACTOR structure
KW  - FACTOR analysis
KW  - SCALING (Social sciences)
N1  - Accession Number: 9604172582; McCrae, R. 1; Email Address: jeffm@mvx.grc.nia.nih.gov Zonderman, Alan B. 1 Costa Jr., Paul T. 1 Bond, Michael H. 2 Paunonen, Sampo V. 3; Affiliation:  1: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland  2: Chinese University of Hong Kong  3: University of Western Ontario; Source Info: Mar96, Vol. 70 Issue 3, p552; Subject Term: PERSONALITY; Subject Term: PSYCHOLOGY; Subject Term: FACTOR structure; Subject Term: FACTOR analysis; Subject Term: SCALING (Social sciences); Number of Pages: 13p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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ER  - 

TY  - JOUR
ID  - 107382284
T1  - Cognitive impairment and risk of stroke in the older population... including commentary by White L.
AU  - Ferrucci L
AU  - Guralnik JM
AU  - Salive ME
AU  - Pahor M
AU  - Corti M
AU  - Baroni A
AU  - Havlik RJ
Y1  - 1996/03//3/ 1/1996
N1  - Accession Number: 107382284. Language: English. Entry Date: 19960901. Revision Date: 20150711. Publication Type: Journal Article; commentary; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Short Portable Mental Status Questionnaire (SPMSQ) (Pfeiffer). NLM UID: 7503062. 
KW  - Cognition Disorders -- In Old Age
KW  - Stroke -- Epidemiology
KW  - Cerebrovascular Disorders
KW  - Psychological Tests
KW  - Risk Factors
KW  - Prospective Studies
KW  - Data Analysis, Statistical
KW  - Record Review
KW  - Epidemiological Research
KW  - Aged
KW  - Human
SP  - 237
EP  - 329
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Gateway Building, Suite 3C-309, Bethesda, MD 20892
U2  - PMID: 8600190.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Gail, Mitchell H.
T1  - Statistics in action.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1996/03//
VL  - 91
IS  - 433
M3  - Article
SP  - 1
SN  - 01621459
AB  - The article focuses on statistics in action with two examples from the past, the advent of the randomized controlled trial and the debate over whether smoking causes lung cancer. These two examples of statistics in action have increased the awareness of the importance of statistical thinking in medical and public health circles. Without the proper statistical tools and principles, and without a close familiarity with the scientific method and with the strengths and weaknesses of experimentation and observational study, the statistician is ill-equipped to contribute effectively to the solution of complex problems. Statistical thinking, data collection and analysis were crucial to understanding the strengths and potential weaknesses of the scientific evidence. This effort enhanced the stature and visibility of statisticians and the statistical method and give rise to new methodologic insights and constructive debate on criteria needed to infer a casual relationship. These ideas form the foundation for much of the current epidemiologic practice.
KW  - STATISTICS
KW  - SCIENTIFIC method
KW  - PUBLIC health
KW  - SMOKING
KW  - LUNGS -- Cancer
KW  - CLINICAL trials
N1  - Accession Number: 9604022976; Gail, Mitchell H. 1; Affiliations: 1: Chief, Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892.; Issue Info: Mar1996, Vol. 91 Issue 433, p1; Thesaurus Term: STATISTICS; Subject Term: SCIENTIFIC method; Subject Term: PUBLIC health; Subject Term: SMOKING; Subject Term: LUNGS -- Cancer; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 13p; Illustrations: 3 Black and White Photographs, 5 Charts; Document Type: Article; Full Text Word Count: 12013
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DB  - buh
ER  - 

TY  - JOUR
ID  - 107368022
T1  - State of the art: antiviral treatment of HIV infection.
AU  - Bechtel-Boenning C
Y1  - 1996/03//1996 Mar
N1  - Accession Number: 107368022. Language: English. Entry Date: 19960501. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - HIV Infections -- Drug Therapy
KW  - Antiviral Agents
KW  - Drugs, Investigational
KW  - Zidovudine
KW  - Didanosine
KW  - Research
KW  - Stavudine
KW  - Interferons
KW  - Protease Inhibitors
SP  - 1
EP  - 13
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Antiretroviral drugs have been the mainstay of treatment for HIV infection. New categories of antiretrovirals and recommendations for treatment have emerged as a result of basic science research, new understandings of the infectious process, and data from clinical studies. This article summarizes the currently available drugs for nurses who act as educators and advocates in helping HIV-infected persons explore their treatment options. Copyright (c) 1996 W.B. Saunders Company
SN  - 0029-6465
AD  - Bldg 10, Rm 8C401, National Institutes of Health, National Institute of Allergies and Infectious Diseases, Bethesda, MD 20892-1756
U2  - PMID: 8604373.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107368021
T1  - Immune-based therapy for HIV.
AU  - Engle J
Y1  - 1996/03//1996 Mar
N1  - Accession Number: 107368021. Language: English. Entry Date: 19960501. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - HIV Infections -- Therapy
KW  - Cytokines
KW  - Immune System -- Drug Effects
KW  - Tumor Necrosis Factor -- Administration and Dosage
KW  - Interleukins -- Administration and Dosage
KW  - Interleukins -- Adverse Effects
KW  - Bone Marrow Transplantation
SP  - 15
EP  - 23
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Even if there were antiretrovirals developed that could completely eliminate HIV from the body, it is thought that immune-based therapy would still be necessary. Pervasive damage occurs in the immune system even in early stages of the disease, and this damage would not be corrected by antiretrovirals. Several different types of immune-based therapies are presented in this article; some have been successful, and some have not been successful. All have been important, however, in increasing the knowledge base of HIV pathogenesis and in narrowing the options that might rebuild the immune system and, thereby, reverse this pathology. Copyright (c) 1996 by W.B. Saunders Company
SN  - 0029-6465
AD  - National Institutes of Health, 4831 Sedgwick Street, NW, Washington, DC 20016
U2  - PMID: 8604377.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107368020
T1  - State of the science: HIV vaccine development.
AU  - Grady C
AU  - Kelly G
Y1  - 1996/03//1996 Mar
N1  - Accession Number: 107368020. Language: English. Entry Date: 19960501. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - AIDS Vaccines
KW  - HIV Infections -- Prevention and Control
KW  - DNA
KW  - Clinical Trials
KW  - Vaccines -- Physiology
SP  - 25
EP  - 39
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Developing a vaccine able to prevent HIV infection would be a great benefit to the world. Vaccines have contributed to substantially reduced morbidity and mortality from several important infectious diseases. However, HIV has some characteristics that distinguish it from many other viruses and make vaccine development challenging. This article discusses scientific strategies, obstacles, and progress to date towards the development of a preventive HIV vaccine. Copyright (c) 1996 by W.B. Saunders Company
SN  - 0029-6465
AD  - National Institute of Nursing Research, National Institutes of Health, Bldg 31, Rm 5B10, Bethesda, MD 20892
U2  - PMID: 8604385.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107368020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107368019
T1  - Application of laboratory diagnostics in HIV nursing.
AU  - Barrick B
AU  - Vogel S
Y1  - 1996/03//1996 Mar
N1  - Accession Number: 107368019. Language: English. Entry Date: 19960501. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - AIDS Serodiagnosis
KW  - Disease Progression -- Diagnosis
KW  - HIV-AIDS Nursing
KW  - HIV Infections -- Classification
KW  - AIDS-Related Opportunistic Infections -- Diagnosis
KW  - Hematologic Diseases
KW  - Hematologic Tests
KW  - Microbiological Techniques
KW  - Immunosorbent Techniques
KW  - DNA Fingerprinting
KW  - CD4 Lymphocyte Count
SP  - 41
EP  - 56
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The HIV epidemic has challenged nursing to rethink the tools it uses and to consider how traditional medical tools may be used in the assessment of nursing problems. This article presents information for the direct care nurse on laboratory tests and how they may be used to meet the traditional needs of physiologic assessment and evaluation and to develop specific nursing interventions. This article discusses tests used for HIV infection, HIV disease progression, presence of microbiologic agents of opportunistic infections commonly associated with advanced HIV disease, and common laboratory tests and their special relevance to HIV. Nursing implications and interventions are discussed throughout the text. Copyright (c) 1996 by W.B. Saunders Company
SN  - 0029-6465
AD  - Bldg 10, Rm 8C300, HIV Research Clinic, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1756
U2  - PMID: 8604386.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107368018
T1  - Preface... HIV infection [corrected] [published erratum appears in NURS CLIN NORTH AM 1996 Mar;31(1):ix].
AU  - Grady C
AU  - Bechtel-Boenning C
Y1  - 1996/03//1996 Mar
N1  - Accession Number: 107368018. Language: English. Entry Date: 19960501. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - HIV Infections
SP  - xv
EP  - xvi
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0029-6465
AD  - National Institute of Nursing Research, National Institutes of Health, Bldg 31/Rm 5B10, Bethesda, MD 20892
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DB  - rzh
ER  - 

TY  - JOUR
ID  - 107368033
T1  - Clinical research: considerations for prospective participants.
AU  - Hutchins SA
AU  - Eckes R
Y1  - 1996/03//1996 Mar
N1  - Accession Number: 107368033. Language: English. Entry Date: 19960501. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - Clinical Research
KW  - Clinical Trials
KW  - Research Ethics
KW  - Consent (Research)
KW  - Research Subjects
KW  - Nursing Role
KW  - Multidisciplinary Care Team
KW  - Research, Interdisciplinary
SP  - 125
EP  - 135
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Many HIV-positive patients are involved in clinical trials. While working with the HIV-positive patient, the nurse is confronted with the challenge of a rapidly changing environment of collective knowledge. The nurse may meet a patient at any stage of drug or biologic development; therefore, it is very important to understand the process of clinical research. This article describes the purpose and process of clinical research, the patient perspective, ethical considerations, and the role of the nurse in biomedical research. Copyright (c) 1996 by W.B. Saunders Company
SN  - 0029-6465
AD  - National Institutes of Health, Bldg 10, Rm 8C414, 9000 Rockville Pike, Bethesda, MD 20892-1756
U2  - PMID: 8604375.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107368033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107384373
T1  - Adolescents rights to refuse medical care for treatment of cancer.
AU  - McGarvey CL
Y1  - 1996/03//
N1  - Accession Number: 107384373. Language: English. Entry Date: 19961001. Revision Date: 20150711. Publication Type: Journal Article; glossary. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA. 
KW  - Patient Rights -- In Adolescence
KW  - Treatment Refusal -- In Adolescence
KW  - Neoplasms -- Therapy -- In Adolescence
KW  - Child Welfare -- Legislation and Jurisprudence -- United States
KW  - Patient Rights -- Legislation and Jurisprudence -- United States
KW  - Parent-Child Relations
KW  - Consent -- In Adolescence
KW  - United States
KW  - Legislation
KW  - Adolescence
SP  - 19
EP  - 25
JO  - Rehabilitation Oncology
JF  - Rehabilitation Oncology
JA  - REHABIL ONCOL
VL  - 14
IS  - 1
CY  - Alexandria, Virginia
PB  - American Physical Therapy Association, Oncology Section
SN  - 2168-3808
AD  - Rehabilitation Medicine Department, National Institutes of Health, Warren G. Magnuson Clinical Center, Bethesda, MD 20892-1604
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-38280-022
AN  - 2015-38280-022
AU  - Behar, Toby N.
AU  - Li, Yong-Xin
AU  - Tran, Hung T.
AU  - Ma, Wu
AU  - Dunlap, Veronica
AU  - Scott, Catherine
AU  - Barker, Jeffery L.
T1  - GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/03//
VL  - 16
IS  - 5
SP  - 1808
EP  - 1818
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Behar, Toby N., National Institutes of Health, Building 36, Room 2CO2, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38280-022. PMID: 8774448 Partial author list: First Author & Affiliation: Behar, Toby N.; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gamma Aminobutyric Acid; Neurons; Migration of Nerve Cells; Calcium Channel. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Mar, 1996. Publication History: Accepted Date: Dec 7, 1995; Revised Date: Dec 5, 1995; First Submitted Date: Sep 9, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - During rat cortical development, when neurons migrate from the ventricular zone to the cortical plate, GABA localizes within the target destinations of migratory neurons. At this time, cells in germinal zones and along migratory pathways express GABA receptor subunit transcripts, implying that in vivo, GABA may be a chemoattractant. We used an in vitro strategy to study putative chemotropic effects of GABA on embryonic rat cortical cells. GABA stimulated neuronal migration in vitro at embryonic day 15 (E15). From E16 onward, two concentration ranges (fM and µM) induced motility. Femtomolar GABA primarily stimulated chemotaxis (migration along a chemical gradient), whereas micromolar GABA predominantly initiated chemokinesis (increased random movement). These effects were mimicked by structural analogs of GABA with relative specificity at GABAA (muscimol), GABAB (R-baclofen), and GABAC (trans- or cis-4-aminocrotonic acid) receptors. Antagonists of GABAB (saclofen) and GABAC (picrotoxin) receptors partially inhibited responses to both femto- and micromolar GABA; however, only responses to femtomolar GABA were partially blocked by bicuculline, a well established antagonist of GABA at GABAA receptors. Hence, chemotactic responses to femtomolar GABA seem to involve all three classes of GABA receptor proteins, whereas chemokinetic responses to micromolar GABA involve GABAB and GABAC receptor proteins. GABA-induced motility was blocked by loading the cells with the Ca2+-chelating molecule bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid, suggesting that intracellular Ca2+ mediates GABA-induced cell movement. Optical recordings of cells loaded with Ca2+ indicator dye revealed that both femto- and micromolar GABA evoked increases in intracellular Ca2+. Thus, GABA-stimulated increases in intracellular Ca2+ may mediate both chemotactic and chemokinetic responses in embryonic cortical cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - migration
KW  - development
KW  - cerebral cortex
KW  - GABA receptor: calcium
KW  - rat
KW  - 1996
KW  - Gamma Aminobutyric Acid
KW  - Neurons
KW  - Migration of Nerve Cells
KW  - Calcium Channel
KW  - Rats
KW  - 1996
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38281-003
AN  - 2015-38281-003
AU  - Wenthold, Robert J.
AU  - Petralia, Ronald S.
AU  - Blahos, Jaroslav II
AU  - Niedzielski, Andrew S.
T1  - Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/03//
VL  - 16
IS  - 6
SP  - 1982
EP  - 1989
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wenthold, Robert J., National Institutes of Health, Building 36, Room SD08, 36 Convent Drive, Bcthcsda, MD, US, 20892-4162
N1  - Accession Number: 2015-38281-003. PMID: 8604042 Partial author list: First Author & Affiliation: Wenthold, Robert J.; Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, MD, US. Release Date: 20160926. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amino Acids; Glutamic Acid; Hippocampus; Pyramidal Neurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: Mar, 1996. Publication History: Accepted Date: Dec 28, 1995; Revised Date: Nov 9, 1995; First Submitted Date: Aug 30, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - The AMPA receptor, which is involved in most fast glutamatergic transmission in the mammalian brain and is expressed in most neurons, is made up of four subunits, GluR1-4. In situ hybridzation, immunocytochemistry studies, and single-cell PCR analyses show that the number and type of AMPA receptor subunits expressed vary among neuronal populations and that two to four subunits usually are expressed in each neuron. Neurons that express two or more subunits theoretically could produce multiple pentameric receptor complexes that differ in their subunit compositions, and these complexes could be targeted to different synaptic populations. To determine whether a single neuronal population produces multiple AMPA receptor complexes, we used a preparation of CA1/CA2 hippocampal pyramidal neurons and immunoprecipitation with subunit-specific antibodies to characterize the receptor complexes. The CA1/CA2 pyramidal neurons express high levels of GluR1-3 and receive multiple excitatory inputs, offering the possibility that distinct receptor complexes may be assembled and expressed selectively at different synaptic populations. Our results suggest the presence of two major populations of AMPA receptor complexes: those made up of GluR1 and GluR2 and those made up of GluR2 and GluR3. Very few complexes contained both GluR1 and GluR3, whereas ∼8% of the total AMPA receptor complexes was homomeric GluR1. The integrity of the receptor complex was verified by measuring [³H]AMPA binding activity in the immunoprecipitated fractions. These results show that AMPA receptor complexes with different subunit compositions are present in CA1/CA2 pyramidal neurons and suggest an additional mechanism to regulate receptor expression in neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptor
KW  - excitatory amino acids
KW  - AMPA
KW  - hippocampus pyramidal neurons
KW  - immunoprecipitation
KW  - receptor subunit
KW  - 1996
KW  - Amino Acids
KW  - Glutamic Acid
KW  - Hippocampus
KW  - Pyramidal Neurons
KW  - 1996
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38281-013
AN  - 2015-38281-013
AU  - Davenport, Roger W.
AU  - Thies, Edda
AU  - Nelson, Phillip G.
T1  - Cellular localization of guidance cues in the establishment of retinotectal topography.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/03//
VL  - 16
IS  - 6
SP  - 2074
EP  - 2085
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Davenport, Roger W., Laboratory of Developmental Neurobiology, National Institutes of Health, 49/5A32, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38281-013. PMID: 8604052 Partial author list: First Author & Affiliation: Davenport, Roger W.; Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160926. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Davenport, Roger W. Major Descriptor: Neurons; Topography; Cellular Neuroscience. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Mar, 1996. Publication History: Accepted Date: Dec 28, 1995; Revised Date: Dec 21, 1995; First Submitted Date: Jul 27, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - [Correction Notice: An Erratum for this article was reported in Vol 16(14) of The Journal of Neuroscience (see record [rid]2015-38423-015[/rid]). In the original article, in Figure 2. The lower portion and scale bar of Figure 2, page 2077, inadvertently were missing. The scale bar for this figure (0.2 mm) should have appeared in print as 15.2 mm in length in the lower panel (E).] Topographic projections of the nervous system are essential to numerous brain functions. They arise during development as a result of encounters between projecting growth cones and particular target cells. Cellular localization of guidance cues can indicate the sequential processes involved in establishment of such topography. The map formed by retinal ganglion cells on their target nuclei has served widely as a model system to investigate mechanisms underlying the highly precise and stereotypic connectivity of the nervous system. To investigate cellular localization of guidance cues in the developing retinotectal system, a three-compartment chamber was created to delimit areas where cultured embryonic chick retinal ganglion axons and tectal cells encounter one another and guidance behavior could be readily assessed. Whereas explants from nasal retinae extended fibers across their natural target population, fibers from temporal regions of retinae failed to invade areas of growing posterior tectal cells. This preservation of relevant guidance information on living cell populations enabled an evaluation of retinal ganglion cell growth cone behavior after encounter with individual tectal cells. Posterior tectal neurons appeared selectively repulsive for temporal retinal ganglion cell growth cones, causing growth cone collapse and retraction. On the contrary, neuroepithelial cells from all regions of the tectum attenuated retinal ganglion axon extension, without inducing sudden retraction. Nasal growth cones traversed or tracked more often along neuroepithelial cells from their natural target area, potentially indicating a second set of guidance cues possibly localized to posterior glia. Together, these differential interactions suggest that development of retinotectal topography critically depends on cell-specific cues, which are distributed selectively on particular populations of target cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - retinotectal
KW  - topographic projection
KW  - growth cone
KW  - neuronal development
KW  - filopodia
KW  - navigation
KW  - guidance
KW  - repulsion
KW  - retraction
KW  - 1996
KW  - Neurons
KW  - Topography
KW  - Cellular Neuroscience
KW  - 1996
U1  - Sponsor: National Institutes of Health, National Institute of Child Health and Human Development, National Research Council, US. Other Details: Research Associateship. Recipients: Davenport, Roger W.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107370165
T1  - Body weight: estimation of risk for breast and endometrial cancers.
AU  - Ballard-Barbash R
AU  - Swanson CA
Y1  - 1996/03/02/Mar96 Supplement
N1  - Accession Number: 107370165. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; proceedings; review; tables/charts. Supplement Title: Mar96 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Body Weight
KW  - Breast Neoplasms
KW  - Endometrial Neoplasms
KW  - Risk Factors
KW  - Body Mass Index
KW  - Body Composition
KW  - Menopause
SP  - 437S
EP  - 41S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 63
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 343, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892-7344
U2  - PMID: 8615337.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107370165&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - MILLS, JAMES L.
AU  - SCOTT, JOHN M.
AU  - KIRKE, PEADAR N.
AU  - McPARTLIN, JOSEPH M.
AU  - CONLEY, MARY R.
AU  - WEIR, DONALD G.
AU  - MOLLOY, ANNE M.
AU  - LEE, YOUNG JACK
T1  - Homocysteine and Neural Tube Defects.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1996/03/02/Mar96 Supplement
M3  - Article
SP  - 756S
EP  - 760S
SN  - 00223166
AB  - It is now well established that folie acid, when taken periconceptionally, can prevent many neu ral tube defects. It is also becoming clear that folie acid does not work by correcting a nutritional deficiency in pregnant women. Rather, it appears that a metabolic defect is responsible for these neural tube defects and that this defect or defects can be corrected by a sufficiently large dose of folie acid. Our recent work demon strates that homocysteine metabolism is likely to be the critical pathway affected by folie acid. We have demonstrated significantly higher homocysteine levels in women carrying affected fetuses than in control women. These findings indicate that one of the en zymes responsible for homocysteine metabolism is likely to be abnormal in affected pregnancies. Animal studies suggest that the conversion of homocysteine to methionine could be the critical step. Rat embryos in culture require methionine for neural tube closure. Methionine synthase, cystathionine synthase, and 5,10 methylene tetrahydrofolate reductase are all im portant in the metabolism of homocysteine in humans. If methionine synthase is the critical enzyme, it would raise the interesting public health issue that vitamin B-12 might be able to stimulate the abnormal enzyme as folie acid does. Adding vitamin B-12 might make it possible to reduce the dose of folie acid required in fortified food, thus allaying concerns about overexposure to folie acid. J. Nutr. 126: 756S-760S, 1996. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - birth defect
KW  - folate
KW  - folic acid
KW  - homocysteine
KW  - neural tube defect
N1  - Accession Number: 89382813; MILLS, JAMES L. 1,2 SCOTT, JOHN M. 3 KIRKE, PEADAR N. 4 McPARTLIN, JOSEPH M. 5 CONLEY, MARY R. 1 WEIR, DONALD G. 5 MOLLOY, ANNE M. 5 LEE, YOUNG JACK 1; Affiliation:  1: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892  2: Pediatrie Epidemiology Section, 6100 Building, Room 7B03, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892  3: Department of Biochemistry, Trinity College, Dublin, Ireland  4: Health Research Board of Ireland, Dublin, Ireland  5: Departmentof Clinical Medicine, Trinity College, Dublin, Ireland; Source Info: Mar96 Supplement, p756S; Author-Supplied Keyword: birth defect; Author-Supplied Keyword: folate; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: homocysteine; Author-Supplied Keyword: neural tube defect; Number of Pages: 5p; Document Type: Article; Language: Spanish
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107265457
T1  - Uncertain value of electronic fetal monitoring in predicting cerebral palsy.
AU  - Nelson KB
AU  - Dambrosia JM
AU  - Ting TY
AU  - Grether JK
Y1  - 1996/03/07/
N1  - Accession Number: 107265457. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by a cooperative agreement with the Center for Environmental Health and Injury Control, Centers for Disease Control and Prevention, in part by funds from the Comprehensive Environmental Response, Compensation, and Liability Act Trust Fund through an interagency agreement with the Agency for Toxic Substances and Disease Registry, Public Health Service, and in part by a training grant from the Department of Health and Human Services, Maternal and Child Health Bureau (MCJ 002001-28-0). NLM UID: 0255562. 
KW  - Cerebral Palsy -- Physiopathology
KW  - Fetal Anoxia -- Diagnosis
KW  - Fetal Monitoring, Electronic
KW  - Cerebral Palsy -- Etiology
KW  - Fetal Anoxia -- Complications
KW  - Fetus
KW  - California
KW  - Risk Factors
KW  - False Positive Results
KW  - Female
KW  - Pregnancy
KW  - Adult
KW  - Infant, Newborn
KW  - Odds Ratio
KW  - Case Control Studies
KW  - Heart Rate, Fetal
KW  - Arrhythmia -- Etiology
KW  - Funding Source
KW  - Human
SP  - 613
EP  - 618
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 334
IS  - 10
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD
U2  - PMID: 8592523.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Gentry, Daniel R.
AU  - Cashel, Michael
T1  - Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/03/15/
VL  - 19
IS  - 6
M3  - Article
SP  - 1373
EP  - 1384
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The <em>spoT</em> gene of <em>Escherichia coli</em> encodes a guanosine 3′,5′-bis(diphosphate) 3′-pyrophosphohydrolase (ppGppase) as well as an apparent guanosine 3′,5′ - bis(diphosphate) synthetase (designated PSII). To determine the regions of the SpoT protein that are required for these two competing activities, we analysed plasmid-borne deletion mutations for their ability to complement chromosomal mutations defective in each activity. We found that a region containing the first 203 amino acids of the 702-amino-acid SpoT protein was sufficient for ppGppase activity while an overlapping region containing residues 67-374 was sufficient for PSII activity. These data indicate that the catalytic sites involved in the two activities are separate but closely linked in the primary sequence of the SpoT protein. A ppGppase-defective δ1-58 deletion mutant strain failed to synthesize ppGpp in response to nutrient limitation, also supporting the notion that PSII activity from wild-type SpoT does not increase in response to nutrient limitation. Using a strain tacking PSII activity but retaining ppGppase activity, we determined the contribution of the RelA protein (ppGpp synthetase I, PSI) to ppGpp synthesis following glucose starvation. We found that the RelA protein activity accounts for the initial burst of ppGpp synthesis at the onset of glucose starvation but that this source of synthesis is absent when amino acids are present during glucose starvation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Mutation (Biology)
KW  - Amino acids
KW  - Glucose
KW  - Monosaccharides
KW  - Ligases
N1  - Accession Number: 21881829; Gentry, Daniel R. 1; Cashel, Michael 1; Email Address: cashel@LMGVAX.NICHD.NIH.gov; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 3B-316, Bethesda, 20892-2785 Maryland, USA; Issue Info: Mar1996, Vol. 19 Issue 6, p1373; Thesaurus Term: Escherichia coli; Thesaurus Term: Mutation (Biology); Subject Term: Amino acids; Subject Term: Glucose; Subject Term: Monosaccharides; Subject Term: Ligases; Number of Pages: 12p; Illustrations: 2 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105854878
T1  - National Cancer Institute Workshop on Genetic Screening for Colorectal Cancer.
AU  - Rossi SC
AU  - Srivastava S
Y1  - 1996/03/20/
N1  - Accession Number: 105854878. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Colorectal Neoplasms
KW  - Genetic Screening
KW  - Animals
KW  - Genetic Counseling
KW  - Middle Age
SP  - 331
EP  - 339
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 6
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7342, USA.
U2  - PMID: 8609641.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854885
T1  - Presence of Mason-Pfizer monkey virus in some stocks of the human HBL-100 mammary epithelial cell line.
AU  - Robert-Guroff M
AU  - Stern TL
AU  - Richardson ES
AU  - Giovanella BC
AU  - Michaels FH
Y1  - 1996/03/20/
N1  - Accession Number: 105854885. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms
KW  - Retrovirus Infections
KW  - Retroviruses
KW  - Tumor Virus Infections
KW  - Breast Neoplasms -- Pathology
KW  - Cell Transformation, Neoplastic
KW  - Cells
KW  - Documentation
KW  - Epithelial Cells
KW  - Epithelium
KW  - Female
KW  - Nucleotides
KW  - Transferases -- Metabolism
SP  - 372
EP  - 374
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 6
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA.
U2  - PMID: 8609647.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104791644
T1  - Associations between drug use and behavioral repertoire in urban youths.
AU  - Johanson, C E
AU  - Duffy, F F
AU  - Anthony, J C
Y1  - 1996/04//
N1  - Accession Number: 104791644. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Adolescent Behavior
KW  - Substance Use Disorders
KW  - Urban Population
KW  - Adolescence
KW  - Child
KW  - Female
KW  - Human
KW  - Male
KW  - Questionnaires
SP  - 523
EP  - 534
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 91
IS  - 4
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Converging with psycho-social research findings, animal and human laboratory studies indicate that behavioral alternatives are important determinants of drug-taking. To investigate associations between how early adolescents spend their time, i.e. their behavioral repertoire and drug use (use of marijuana, crack/cocaine or inhalants), we analyzed data from an epidemiological sample of 1516 urban middle-school students who had completed private interviews in spring 1993. The interview included a 36-item questionnaire to assess how frequently the youth engaged in different activities; history of drug-taking was assessed separately. Multiple logistic regression was used to estimate associations between drug use and each of seven behavioral domains as well as sex, age and racial-ethnic status. Youths spending a great deal of time working for pay and assuming other adult-like roles were more likely to have initiated drug use (estimated odds ratio, OR = 3.49; p = 0.002). Those who spent much time in religious activities were less likely (OR = 0.2, p <0.001). An exploratory search for interactions disclosed other associations that merit attention in future research. These results corroborate evidence on the potential etiological significance of behavioral repertoire in relation to risk of drug use.
SN  - 0965-2140
AD  - Etiology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, USA.
U2  - PMID: 8857378.
DO  - 10.1111/j.1360-0443.1996.tb02310.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104791644&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107222302
T1  - Adolescents and sexually transmitted diseases.
AU  - Hitchcock PJ
Y1  - 1996/04//
N1  - Accession Number: 107222302. Language: English. Entry Date: 19991101. Revision Date: 20150818. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225. 
KW  - Sexually Transmitted Diseases -- In Adolescence
KW  - Risk Factors
KW  - Sexually Transmitted Diseases -- Epidemiology -- In Adolescence
KW  - Sexual Partners -- In Adolescence
KW  - Cervix
KW  - Chlamydia
KW  - Acquired Immunodeficiency Syndrome -- In Adolescence
KW  - Adolescence
SP  - 79
EP  - 85
JO  - AIDS Patient Care & STDs
JF  - AIDS Patient Care & STDs
JA  - AIDS PATIENT CARE STDS
VL  - 10
IS  - 2
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1087-2914
AD  - Chief, Sexually Transmitted Diseases Branch, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Solar Building 3A24, Bethesda, MD 20892
U2  - PMID: 11361711.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107222302&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107371004
T1  - Programmed instruction: biotherapy module V. Hematopoietic growth factors.
AU  - DeLaPena L
AU  - Woolery-Antill M
AU  - Tomaszewski JG
AU  - Gantz S
AU  - Bernato DL
AU  - DiLorenzo K
AU  - Molenda J
AU  - Kryk JA
Y1  - 1996/04//1996 Apr
N1  - Accession Number: 107371004. Language: English. Entry Date: 19960601. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Hematopoietic Cell Growth Factors
KW  - Biological Therapy
KW  - Education, Continuing (Credit)
KW  - Programmed Instruction
KW  - Hematopoiesis
KW  - Hematopoietic Cell Growth Factors -- Classification
KW  - Hematopoietic Cell Growth Factors -- Therapeutic Use
KW  - Hematopoietic Cell Growth Factors -- Administration and Dosage
KW  - Hematopoietic Cell Growth Factors -- Adverse Effects
KW  - Hematopoietic Cell Growth Factors -- Economics
KW  - Granulocyte Colony-Stimulating Factor
KW  - Erythropoietin
KW  - Oncologic Nursing
KW  - Granulocyte-Macrophage Colony-Stimulating Factor
KW  - Drugs, Investigational -- Adverse Effects
KW  - Patient Education
SP  - 135
EP  - 151
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 19
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0162-220X
AD  - National Institutes of Health, Clinical Center, Dept of Nursing, Bethesda, Maryland
U2  - PMID: 8635167.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107371004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yahnke, Christopher J.
AU  - Johnson, Warren E.
AU  - Geffen, Eli
AU  - Smith, Deborah
AU  - Hertel, Fritz
AU  - Roy, Michael S.
AU  - Bonacic, Cristian F.
AU  - Fuller, Todd K.
AU  - Blaire
AU  - Wayne, Robert K.
T1  - Darwin’s Fox: A Distinct Endangered Species in a Vanishing Habitat.
JO  - Conservation Biology
JF  - Conservation Biology
Y1  - 1996/04//
VL  - 10
IS  - 2
M3  - Article
SP  - 366
EP  - 375
PB  - Wiley-Blackwell
SN  - 08888892
AB  - The temperate rain forest of Chiloé Island, Chile, is inhabited by an endemic fox (Dusicyon fulvipes) first described by Charles Darwin and now designated Darwin’s fox. Despite morphological differences, Darwin’s fox has been considered only an insular subspecies of the mainland chilla fox (D. griseus). This follows the assumption that the island population, with an estimated population of less than 500, has been separated from the mainland chilla fox for only about 15,000 years and may have received occasional immigrants from the mainland. Consequently, this island population has not been protected as endangered or bred in captivity. Recently, a population of Darwin’s fox was discovered on the Chilean mainland 600 km north of Chiloé Island. This population exists in sympatry with chilla and possibly culpeo (D. culpaeus) foxes, which suggests that Darwin’s fox may be reproductively isolated. To clarify the phylogenetic position of Darwin’s fox, we analyzed 344 bp of mitochondrial DNA control-region sequence of the three species of Chilean foxes. Darwin’s foxes from the island and mainland populations compose a monophyletic group distinct from the two other Chilean fox species. This indicates that Darwin’s fox was probably an early inhabitant of central Chile, and that its present distribution on the mainland may be a relict of a once much wider distribution. Our results highlight the ability of molecular genetic techniques to uncover historical relationships masked by recent events, such as local extinctions. The “rediscovery” of Darwin’s fox as a distinct species implies that greater significance should be given to the protection of this species and its unique habitat and to documenting the extent of its mainland distribution. (English) [ABSTRACT FROM AUTHOR]
AB  - El zorro de Darwin: una especie particular en peligro en un hábitat que está desapareciendoLos bosques lluviosos templados de la isla de Chiloé, en Chile están habitados por un zorro endémico (Dusicyon fulvipes) que fué descrito por primera vez por Charles Darwin y que en la actualidad lleva el nombre de zorro de Darwin. A pesar de las diferencias morfológicas, el zorro de Darwin ha sido considerado sólo como una subespecie insular del zorro chilla (D. griseus) que habita en el continente. Esto se basa en la suposición de que la población de la isla, con un tamaño poblacional estimado inferior a 500 individuos, ha estado separada de los zorros chilla del continente por sólo unos 15,000 años y que podría haber recibido inmigrantes ocasionales del continente. En consecuencia, esta población insular no ha sido protegida como una especie en peligro, ni ha sido criada en cautiverio. Recientemente, una población de zorros de Darwin fue descubierta en la parte continental de Chile a unos 600 km al norte de la isla de Chiloé. Esta población existe en simpatria con los zorros chilla y posiblemente los zorros culpeo (D. culpaeus), lo que sugiere que los zorros de Darwin podrían estar aislados reproductivamente. A los efectos de clarificar la ubiación filogenética de los zorros de Darwin analizamos 344 pares de bases de la sequencia de la región control del ADN mitocondrial de las tres especies de zorros chilenos. Los zorros de Darwin de las poblaciones de la isla y del continente formaron un grupo monofilético distinto de las otras dos especies de zorros Chilenos. Esto indica que el zorro de Darwin fue probablemente un residente temprano de la región central de Chile y que su distribución presente en el continente sería un relicto de una distribución mucho mas amplia. Nuestros resultados resaltan la habilidad de las técnicas de genética molecular para revelar relaciones históricas que se encuentran mascaradas por eventos recientes, tales como extinciones locales. El redescubrimiento de los zorros de Darwin como una especie distinta, implica que se debe dar una mayor importancia a la protección de esta especie y de su hábitat particular, así como a la documentación de la amplitud de su distribución continental. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Conservation Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Endangered species
KW  - Chile (Chiloe Island)
KW  - Fox, chilla and culpeo
KW  - Fox, Darwin's
KW  - Phylogenetics
KW  - Species comparison
N1  - Accession Number: 8172393; Yahnke, Christopher J. 1; Johnson, Warren E. 2; Geffen, Eli 3; Smith, Deborah 3; Hertel, Fritz 3; Roy, Michael S. 4; Bonacic, Cristian F. 5; Fuller, Todd K. 6; Blaire 3; Wayne, Robert K. 3; Affiliations: 1: Department of Biological Sciences, Northern Illinois University, Dekalb, IL 60115, U.S.A.; 2: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21702, U.S.A.; 3: Department of Biology, University of California, Los Angeles, CA 90024, U.S.A.; 4: Department of Population Biology, University of Copenhagen, Universitetspaken 15, DK-2100, Copenhagen, Denmark; 5: Departamento de Ingenieria Forestal, Pontificia Universidad Católica de Chile, Casilla 306, correo 22, Santiago, Chile; 6: Department of Forestry and Wildlife Management, University of Massachusetts, Amherst, MA 01003, U.S.A.; Issue Info: Apr1996, Vol. 10 Issue 2, p366; Thesaurus Term: Endangered species; Author-Supplied Keyword: Chile (Chiloe Island); Author-Supplied Keyword: Fox, chilla and culpeo; Author-Supplied Keyword: Fox, Darwin's; Author-Supplied Keyword: Phylogenetics; Author-Supplied Keyword: Species comparison; Number of Pages: 10p; Document Type: Article
L3  - 10.1046/j.1523-1739.1996.10020366.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8172393&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Marikovsky, Moshe
AU  - Vogt, Peter
AU  - Eriksson, Elof
AU  - Rubin, Jeffrey S.
AU  - Taylor, William G.
AU  - Sasse, Joachim
AU  - Klagsbrun, Michael
T1  - Wound Fluid-Derived Heparin-Binding EGF-Like Growth Factor (HB-EGF) Is Synergistic with Insulin-Like Growth Factor-I For Balb/MK Keratinocyte Proliferation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/04//
VL  - 106
IS  - 4
M3  - Article
SP  - 616
EP  - 621
SN  - 0022202X
AB  - Epidermal cell proliferation is required for re-epithelialization during wound repair. Re-epithelialization of partial thickness excisional wounds in pigs is complete by 6 days after injury. The presence of insulin- like growth factor-I (IGF-I) and heparin-binding molecules that are mitogenic for keratinocytes was examined in wound fluid obtained daily from these wounds. Two significant heparin-binding growth factor activities for Balb/MK keratinocytes were detected, a major one that was eluted from a heparin affinity column with 1.1 M NaCl and a minor one with 0.5 M NaCl. These activities appeared 1 day after injury, were maximal by 2-3 days later, and disappeared by 6 days after injury. The molecule eluting with 1.1 M NaCl was heparin-binding EGF-like (HE-. EGF). The levels of IGF-I in wound fluid were 45-90 ng/ml during the first 3 days following injury, decreased thereafter, and were not detectable 6 days after injury. IGF-I at 100 ng/ml, increased HB-EGF mitogenic activity for Balb/MK keratinocytes by 40- 50-fold. We conclude that the synergism between IGF-I and HB-EGF and their relative concentrations at the various days after injury may be important variables for regulating re-epithelialization during wound repair. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WOUNDS & injuries
KW  - EPIDERMAL growth factor
KW  - HEPARIN
KW  - CARRIER proteins
KW  - CELL proliferation
KW  - KERATINOCYTES
KW  - INSULIN
KW  - <em>epidermal growth factor</em>
KW  - <em>insulin</em>
KW  - <em>re-epithelialization</em>
KW  - <em>wound repair</em>
N1  - Accession Number: 12345413; Marikovsky, Moshe 1 Vogt, Peter 2,3 Eriksson, Elof 3 Rubin, Jeffrey S. 4 Taylor, William G. 4 Sasse, Joachim 5 Klagsbrun, Michael 6; Affiliation:  1: Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100.  2: Department of Cell Biology, The Weizmann Institute of Science, Isreal.  3: Department of Plastic Surgery, Brigham and Womens Hospital Boston, Massachusetts.  4: National Institutes of Health, Bethesda, Maryland.  5: Shriners Institute For Crippled Children, Tampa, Florida.  6: Department of Surgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, U.S.A.; Source Info: Apr96, Vol. 106 Issue 4, p616; Subject Term: WOUNDS & injuries; Subject Term: EPIDERMAL growth factor; Subject Term: HEPARIN; Subject Term: CARRIER proteins; Subject Term: CELL proliferation; Subject Term: KERATINOCYTES; Subject Term: INSULIN; Author-Supplied Keyword: <em>epidermal growth factor</em>; Author-Supplied Keyword: <em>insulin</em>; Author-Supplied Keyword: <em>re-epithelialization</em>; Author-Supplied Keyword: <em>wound repair</em>; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12345413
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12345413&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Owens, David M.
AU  - Zainal, Theodor A.
AU  - Jetten, Anton M.
AU  - Smart, Robert C.
T1  - Localization and Expression of Cornifin-α/SPRR1 in Mouse Epidermis, Anagen Follicles, and Skin Neoplasms.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/04//
VL  - 106
IS  - 4
M3  - Article
SP  - 647
EP  - 654
SN  - 0022202X
AB  - Recently, cornifin-α/SPRR1 has been identified as a putative precursor protein of the cornified cell envelope. In this study, the expression and localization of cornifin-α/SPRR1 was examined in untreated and tumor promoter-treated mouse skin, hair follicles, and skin neoplasms. Western analysis with antiserum (SQ37A) to a rabbit cornifin-α peptide or antiserum (SQ37C) to a human SPRR1 peptide demonstrated a 31-kDa immunoreactive protein in mouse epidermis and Northern analysis revealed the presence of a 1-kb mRNA. Immunohistochemical staining of mouse skin with SQ37A or SQ37C revealed intense and specific staining of the infundibulum, isthmus, and of Henle's layer of the inner root sheath of the lower anagen hair follicle and weak staining of the telogen follicle and the suprabasal layers of the epidermis. Treatment of mouse skin with 12-O-tetradecanoyl- phorbol-13-acetate (TPA) produced a large increase in cornifin-α/SPRR1 protein and mRNA. Immunohistochemical localization of cornifin-α/SPRR1 in TPA-treated skin indicated that cornifin-α/SPRR1 was increased in the suprabasal epidermis but not in the follicle. <em>sn</em>-1,2-Didecanoylglycerol, a model lipid second messenger, produced an increase in cornifin- α/SPRR1 protein similar to that of TPA, while Mirex, a non-phorbol ester-type promoter had no effect. Topical doses of retinoic acid did not repress TPA- induced cornifin-α/SPRR1 expression. Papillomas demonstrated a 10- and 100-fold increase in cornifin-α/SPRR1 protein and mRNA, and expression was restricted to suprabasal cells. Squamous cell carcinomas exhibited an intermediate level of cornifin-α protein, and expression was restricted to keratinized areas. These data indicate: i) cornifin-α/SPRR1 is expressed in mouse skin; ii) cornifin-α/SPRR1 is localized to specific areas of the anagen hair follicle with weak staining in the telogen follicle and epidermis; iii) epidermal cornifin-α/SPRR1 expression is induced by phorbol ester and <em>sn</em>-1,2-didecanoylglycerol but not mirex; and iv) papillomas and squamous cell carcinomas demonstrate a constitutive increase in cornifin-α/SPRR1 in differentiated areas of the neoplasms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HAIR follicles
KW  - EPIDERMIS
KW  - TUMORS
KW  - PROTEIN precursors
KW  - WESTERN immunoblotting
KW  - IMMUNE serums
KW  - IMMUNOHISTOCHEMISTRY
KW  - INFUNDIBULUM (Brain)
KW  - ISTHMUSES
KW  - <em>cornified envelope</em>
KW  - <em>cornifin/SPRR</em>
KW  - <em>keratinocytes</em>
N1  - Accession Number: 12345463; Owens, David M. 1 Zainal, Theodor A. Jetten, Anton M. 2 Smart, Robert C. 1; Affiliation:  1: Department of Toxicology. North Carolina State University. Raleigh. North Carolina, North Carolina, U.S.A.  2: Cell Biology Section. Laboratory of Pulmonary Pathobiology. National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, U.S.A.; Source Info: Apr96, Vol. 106 Issue 4, p647; Subject Term: HAIR follicles; Subject Term: EPIDERMIS; Subject Term: TUMORS; Subject Term: PROTEIN precursors; Subject Term: WESTERN immunoblotting; Subject Term: IMMUNE serums; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: INFUNDIBULUM (Brain); Subject Term: ISTHMUSES; Author-Supplied Keyword: <em>cornified envelope</em>; Author-Supplied Keyword: <em>cornifin/SPRR</em>; Author-Supplied Keyword: <em>keratinocytes</em>; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1111/1523-1747.ep12345463
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12345463&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hardas, Bhushan D.
AU  - Zhao, Xingping
AU  - Zhang, Ji
AU  - Longqing, Xia
AU  - Stoll, Stefan
AU  - Elder, James T.
T1  - Assignment of Psoriasin to Human Chromosomal Band 1q21: Coordinate Overexpression of Clustered Genes is Psoriasis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/04//
VL  - 106
IS  - 4
M3  - Article
SP  - 753
EP  - 758
SN  - 0022202X
AB  - Psoriasin is an abundant low molecular weight protein in keratinocytes from psoriatic lesions. Because of similarities in gene structure and expression to other genes on human chromosomal band 1q21, we hypothesized that psoriasin might also map to this region. To test this hypothesis, we identified and used a genomic λ clone (λ9.2) as a probe for fluorescent <em>in situ</em> hybridization. &lamda;9.2 detected the 1q21 region in 81% of 52 chromosomes 1 examined, although it also hybridized to acrocentric chromosomes. A 9.2 DNA yielded polymerase chain reaction amplification of a 121-bp sequence colinear with psoriasin cDNA, as did genomic DNA from hybrid cell lines containing all or part of chromosome 1. The psoriasin gene was present on a 380-kb yeast artificial chromosome clone that was previously mapped to 1q21 and shown to contain calcydin; here it is also shown to contain MRP8 and CaN19. Psoriasin and several other tightly linked 1q21 genes were markedly overexpressed in psoriatic lesions, suggesting a role for these clustered genes in the regulation of epidermal proliferation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSORIASIS
KW  - PROTEINS
KW  - CHROMOSOME banding
KW  - GENE expression
KW  - KERATINOCYTES
KW  - HUMAN chromosomes
KW  - IN situ hybridization
KW  - POLYMERASE chain reaction
KW  - <em>gene regulation</em>
KW  - <em>human genome</em>
KW  - <em>S100 proteins</em>
KW  - <em>yeast artficial chromosomes</em>
N1  - Accession Number: 12345807; Hardas, Bhushan D. 1 Zhao, Xingping 1 Zhang, Ji 2 Longqing, Xia 1 Stoll, Stefan 1 Elder, James T. 1,3; Affiliation:  1: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, U.S.A.  2: National Center for Human Genome Research, National Institutes of Health, 9000 Rockville Pike, Building 49/Room 4A22, Bethesda, MD 20892.  3: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, U.S.A.; Source Info: Apr96, Vol. 106 Issue 4, p753; Subject Term: PSORIASIS; Subject Term: PROTEINS; Subject Term: CHROMOSOME banding; Subject Term: GENE expression; Subject Term: KERATINOCYTES; Subject Term: HUMAN chromosomes; Subject Term: IN situ hybridization; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: <em>gene regulation</em>; Author-Supplied Keyword: <em>human genome</em>; Author-Supplied Keyword: <em>S100 proteins</em>; Author-Supplied Keyword: <em>yeast artficial chromosomes</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12345807
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12345807&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McGrath, John A.
AU  - Darling, Thomas
AU  - Gatalica, Biljana
AU  - Pohla-Gubo, Gabrielle
AU  - Hintner, Helmut
AU  - Christiano, Angela M.
AU  - Yancey, Kim
AU  - Uitto, Jouni
T1  - A Homozygous Deletion Mutation in the Gene Encoding the 180-kDa Bullous Pemphigoid Antigen (BPAG2) in a Family with Generalized Atrophic Benign Epidermolysis Bullosa.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/04//
VL  - 106
IS  - 4
M3  - Article
SP  - 771
EP  - 774
SN  - 0022202X
AB  - The 180-kDa bullous pemphigoid antigen (BPAG2) is a candidate gene/protein for mutations in some forms of junctional epidermolysis bullosa. In this study, we searched for mutations in BPAG2 in a large Austrian pedigree with generalized atrophic benign epidermolysis bullosa, a distinct nonlethal form of junctional epidermolysis bullosa, using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis of the polymerase chain reaction products, and direct nucleotide sequencing. We identified a homozygous 2-bp deletion within the coding region of BPAG2 in the affected individuals. This mutation results in a frame- shift and downstream stop codons on both alleles, predicting an absence of functional protein. These findings illustrate the molecular basis of the skin fragility in this family and attest to the importance of the 180-kDa bullous pemphigoid antigen in the attachment of the epidermis to the underlying dermoepidermal basement membrane. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDERMOLYSIS bullosa
KW  - MUTATION (Biology)
KW  - PEMPHIGUS
KW  - ANTIGENS
KW  - POLYMERASE chain reaction
KW  - GENE amplification
KW  - DNA
KW  - NUCLEOTIDE sequence
KW  - EPIDERMIS
N1  - Accession Number: 12345821; McGrath, John A. 1 Darling, Thomas 2 Gatalica, Biljana 1 Pohla-Gubo, Gabrielle 3 Hintner, Helmut 3 Christiano, Angela M. 1 Yancey, Kim 2 Uitto, Jouni 1; Affiliation:  1: Department of Dermatology and Cutaneous Biology, Jefferson Medical College. and Section of Molecular Dermatology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda. Maryland. U.S.A.  3: Department of Dermatology, General Hospital, Salzburg, Austria.; Source Info: Apr96, Vol. 106 Issue 4, p771; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: MUTATION (Biology); Subject Term: PEMPHIGUS; Subject Term: ANTIGENS; Subject Term: POLYMERASE chain reaction; Subject Term: GENE amplification; Subject Term: DNA; Subject Term: NUCLEOTIDE sequence; Subject Term: EPIDERMIS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12345821
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Steinert, Peter M.
AU  - Chung, Soo-II
AU  - Yoneda, Kozo
AU  - Kim, Soo-Youl
T1  - Expression of Transglutaminase 1 in Keratinocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/04//
VL  - 106
IS  - 4
M3  - Letter
SP  - 802
EP  - 803
SN  - 0022202X
AB  - Presents a letter to the editor as a reply on the expression of transglutaminase 1 in keratinocytes.
KW  - LETTERS to the editor
KW  - TRANSGLUTAMINASES
N1  - Accession Number: 12346465; Steinert, Peter M. 1 Chung, Soo-II 2 Yoneda, Kozo 3 Kim, Soo-Youl 4; Affiliation:  1: Laboratory of Skin Biology National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda, Maryland. U.S.A.  2: Green Cross Corporation Kiheung-Eup, Yongin-goon, Kyounggi-do, Republic of Korea.  3: Department of Dermatology Faculty of Medicine Kyoto University Kyoto 606, Japan.  4: Pacific Corporation Kiheung-Eup, Yongin-goon, Kyounggi-do, Republic of Korea.; Source Info: Apr96, Vol. 106 Issue 4, p802; Subject Term: LETTERS to the editor; Subject Term: TRANSGLUTAMINASES; Number of Pages: 2p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12346465
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - De Bellis, Michael D.
AU  - Burke, Lillian
AU  - Trickett, Penelope K.
AU  - Putnam, Frank W.
T1  - Antinuclear Antibodies and Thyroid Function in Sexually Abused Girls.
JO  - Journal of Traumatic Stress
JF  - Journal of Traumatic Stress
Y1  - 1996/04//
VL  - 9
IS  - 2
M3  - Article
SP  - 369
EP  - 378
SN  - 08949867
AB  - Sexually abused girls manifest dysregulation of physiological stress response systems. In this exploratory investigation, 14 sexually abused and 13 control girls, ages 8-15 years, recruited from a prospective, longitudinal study, underwent plasma antinuclear antibody and thyroid function tests. Thyroid function tests and plasma antinuclear antibody titers did not differ between sexually abused and control girls. However, a significantly higher incidence of plasma antinuclear antibody titers was seen in abused subjects when compared with the frequency of positive antinuclear antibody titers in a sample of 22 adult healthy female volunteers, ages 20-58 years. These findings suggest that sexually abused girls may show evidence of an alteration in normal immune homeostatic function. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Traumatic Stress is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SEXUALLY abused children
KW  - CHILD sexual abuse
KW  - STRESS (Psychology)
KW  - GIRLS
KW  - ANTINUCLEAR factors
KW  - AUTOANTIBODIES
KW  - HOMEOSTASIS
KW  - antinuclear antibodies
KW  - childhood sexual abuse
KW  - psychoneuroimmunology
KW  - thyroid function
N1  - Accession Number: 9605213111; De Bellis, Michael D. 1 Burke, Lillian 2 Trickett, Penelope K. 3 Putnam, Frank W. 4; Affiliation:  1: Assistant Professor of Psychiatry, Dept. of Child and Adolescent Psychiatry, Western Psychiatric Institute and Clinic, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2593  2: Internist and Biotechnology Fellow, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892  3: Research Associate Professor, University of Southern California, Dept. of Psychology, Los Angeles, California 90089-1061  4: Senior investigator, Laboratory of Developmental Psychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892; Source Info: Apr96, Vol. 9 Issue 2, p369; Subject Term: SEXUALLY abused children; Subject Term: CHILD sexual abuse; Subject Term: STRESS (Psychology); Subject Term: GIRLS; Subject Term: ANTINUCLEAR factors; Subject Term: AUTOANTIBODIES; Subject Term: HOMEOSTASIS; Author-Supplied Keyword: antinuclear antibodies; Author-Supplied Keyword: childhood sexual abuse; Author-Supplied Keyword: psychoneuroimmunology; Author-Supplied Keyword: thyroid function; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107340587
T1  - Laryngeal muscle activity during speech breaks in adductor spasmodic dysphonia.
AU  - Nash EA
AU  - Ludlow CL
Y1  - 1996/04//
N1  - Accession Number: 107340587. Language: English. Entry Date: 19971001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts; tracings. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8607378. 
KW  - Laryngeal Muscles -- Physiopathology
KW  - Voice Disorders -- Physiopathology
KW  - Speech -- Physiology
KW  - Speech Disorders -- Etiology
KW  - Electromyography
KW  - Electrodes
KW  - Case Control Studies
KW  - Comparative Studies
KW  - Valsalva's Maneuver
KW  - Speech Production Measurement
KW  - Descriptive Statistics
KW  - Wilcoxon Rank Sum Test
KW  - P-Value
KW  - Analysis of Variance
KW  - Male
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Human
SP  - 484
EP  - 489
JO  - Laryngoscope
JF  - Laryngoscope
JA  - LARYNGOSCOPE
VL  - 106
IS  - 4
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0023-852X
AD  - Voice and Speech Section, National Institute on Deafness and Other Communication Disorders, Bethesda, MD
U2  - PMID: 8614226.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rajapandi, Thavamani
AU  - Oliver, Donald
T1  - Integration of SecA protein into the Escherichia coli inner membrane is regulated by its amino-terminal ATP-binding domain.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/04//
VL  - 20
IS  - 1
M3  - Article
SP  - 43
EP  - 51
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - SecA protein, the ATPase promoting translocation of proteins across the <em>Escherichia coli</em> inner membrane, contains two ATP-binding domains that differ greatly in their affinity for bound nucieotide. In order to define more precisely the location of the high-affinity nucleotide-binding site, oligonucleotlde-directed mutagenesis was used to introduce cysteine residues into the SecA sequence, and a cysteine-specific cleavage reagent was employed to generate defined peptides of SecA protein after photocross-linking with [α-32P]-ATP. This analysis revealed that the nucieotide was crosslinked between amino acid residues 75 and 97 of SecA protein. The biochemical function of the high affinity ATP-binding domain was explored by subcellular fractionation studies which demonstrated that SecA proteins defective in this region were found almost exclusively in their integral membrane form, while SecA proteins with defects in the low-affinity ATP-domain showed a normal distribution of cytosolic, peripheral and integral membrane forms. Interestingly, the SecA51(Ts) protein that has a Leu to Pro substitution at amino acid residue 43 bound ATP with high affinity, but its fractionation pattern and translocation ATPase activity were similar to those of proteins with defects in the high-affinity ATP-binding site. These results delimit more precisely the high-affinity ATP-binding domain of SecA, indicate the importance of the early amino-terminal region of SecA protein in the functioning of this domain, and demonstrate the role of this domain in regulating penetration of SecA protein into the inner membrane. Our results lead to a simple model for the regulation of a cycle of SecA insertion into, and de-insertion from. the inner membrane by the activity of the high-affinity ATP-binding domain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Escherichia coli
KW  - Adenosine triphosphatase
KW  - Binding sites (Biochemistry)
KW  - Proteins
KW  - Translocation (Genetics)
KW  - Nucleotides
KW  - Mutagenesis
N1  - Accession Number: 21342769; Rajapandi, Thavamani 1,2; Oliver, Donald 1; Email Address: doliver@wesleyan.edu; Affiliations: 1: Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut 06459, USA; 2: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: Apr1996, Vol. 20 Issue 1, p43; Thesaurus Term: Escherichia coli; Thesaurus Term: Adenosine triphosphatase; Thesaurus Term: Binding sites (Biochemistry); Subject Term: Proteins; Subject Term: Translocation (Genetics); Subject Term: Nucleotides; Subject Term: Mutagenesis; Number of Pages: 9p; Illustrations: 6 Diagrams, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107370928
T1  - Physical therapists play an important role in treating lymphedema.
AU  - Augustine E
AU  - Humble CA
Y1  - 1996/04//1996 Apr
N1  - Accession Number: 107370928. Language: English. Entry Date: 19960601. Revision Date: 20150819. Publication Type: Journal Article; commentary; letter; response. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Lymphedema -- Therapy
KW  - Physical Therapy
SP  - 421
EP  - 422
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 23
IS  - 3
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
SN  - 0190-535X
AD  - Oncology Services Coordinator, National Institutes of Health, Bethesda, MD
U2  - PMID: 8801502.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107370928&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107370932
T1  - The relationship between stress and the development of breast cancer: a literature review.
AU  - Bryla CM
Y1  - 1996/04//1996 Apr
N1  - Accession Number: 107370932. Language: English. Entry Date: 19960601. Revision Date: 20150819. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Breast Neoplasms
KW  - Stress, Psychological
KW  - Personality
KW  - Life Change Events
KW  - Immune System -- Physiology
KW  - Stress Management
KW  - Support, Psychosocial
KW  - Oncologic Nursing
KW  - Literature
KW  - Selye's Stress Theory
KW  - Female
SP  - 441
EP  - 448
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 23
IS  - 3
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - Purpose/Objectives: To review literature that explores the relationship between stress and the development of breast cancer and investigates the immune system as a possible mediator. Personality traits, response to stress, and stressful life events are considered. Data Sources: Published articles, book chapters, books, and workbooks from nursing and medical literature. Data Synthesis: Studies show that a relationship exists between stress and the development of breast cancer. Most of the literature describes this relationship according to the patient's personality traits, her response to stress, or the occurrence of stressful life events. The immune system may mediate the physiologic influence of stress on breast cancer. Conclusions: Although the difficulty of measuring stress makes it difficult to demonstrate a tangible relationship between stress and breast cancer, studies reveal that stress is related to breast cancer in various ways. Dealing positively with stress may improve the quality of life of patients with breast cancer. Implications for Nursing Practice: Nurses must understand the ubiquitous nature of stress and its relationship to breast cancer. Although they may not be able to prevent stress, patients can learn techniques (e.g., stress management, social support, communication, laughing and crying) to deal with it positively.
SN  - 0190-535X
AD  - Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD
U2  - PMID: 8801505.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107372859
T1  - The therapeutic alliance: enhancing client-practitioner relationships.
AU  - Mauras-Neslen E
AU  - Neslen SE
Y1  - 1996/04//1996 Apr
N1  - Accession Number: 107372859. Language: English. Entry Date: 19960601. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 9602488. 
KW  - Professional-Patient Relations
KW  - Cultural Diversity
KW  - Occupational Therapists
KW  - Self Assessment
KW  - Attitude of Health Personnel
KW  - Patient Attitudes
KW  - Empathy
SP  - 20
EP  - 27
JO  - OT Practice
JF  - OT Practice
JA  - OT PRACT
VL  - 1
IS  - 4
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
SN  - 1084-4902
AD  - National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104791346
T1  - A validation study of an Italian version of the Brief Pain Inventory (Breve Questionario per la Valutazione del Dolore).
AU  - Caraceni, A
AU  - Mendoza, T R
AU  - Mencaglia, E
AU  - Baratella, C
AU  - Edwards, K
AU  - Forjaz, M J
AU  - Martini, C
AU  - Serlin, R C
AU  - de Conno, F
AU  - Cleeland, C S
Y1  - 1996/04//1996 Apr
N1  - Accession Number: 104791346. Language: English. Entry Date: 20110610. Revision Date: 20161113. Publication Type: journal article; clinical trial; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Brief Pain Inventory (BPI). Grant Information: R01 CA026582/CA/NCI NIH HHS/United States. NLM UID: 7508686. 
KW  - Pain Measurement -- Equipment and Supplies
KW  - Adult
KW  - Aged
KW  - Evaluation Research
KW  - Factor Analysis
KW  - Female
KW  - Human
KW  - Italy
KW  - Language
KW  - Male
KW  - Middle Age
KW  - Neoplasms -- Complications
KW  - Pain -- Diagnosis
KW  - Pain -- Psychosocial Factors
KW  - Pain -- Therapy
KW  - Quality of Life
KW  - Reproducibility of Results
KW  - Treatment Outcomes
KW  - Clinical Trials
KW  - Brief Pain Inventory
SP  - 87
EP  - 92
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 65
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Aim of this study was to validate the Italian version of the Brief Pain Inventory (BPI), Breve Questionario per la Valutazione del Dolore (BQVD), which is a multidimensional instrument to assess pain intensity and pain interference with daily functions. A group of 110 patients with cancer pain were enrolled in the study and were administered the BQVD and the Therapy Impact Questionnaire (TIQ) which is a valid instrument for quality of life assessment in cancer patients. Cronbach's alphas were computed for the interference and severity scales in assessing reliability. Confirmatory factor analysis was utilized to ascertain construct validity of the BQVD. Measures of interference and of intensity were calculated a priori from the TIQ result and were used in correlated correlations. Alpha coefficients for the pain severity and the pain interference scale were above 0.75. Confirmatory factor analysis showed that a 2-factor solution for the BQVD structure was interpretable and provided adequate fit for the data. The correlation with the TIQ items showed a stronger association between factor 1 (interference) and the interference with affect and activity measure from the TIQ, while factor 2 (severity) was more strongly associated with the TIQ pain severity measure. In comparison with other non-italian samples our results show a lower reliability estimate. Overall the analysis of these data shows that the BQVD is a useful and valid tool in assessing pain and its impact on patients' quality of life which could also help in developing international and cross-cultural studies in cancer pain.
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy. caraceni@micronet.it
U2  - PMID: 8826494.
DO  - 10.1016/0304-3959(95)00156-5
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Glover, Deborah
AU  - Durbin, Mary L.
AU  - Huttley, Gavin
AU  - Clegg, Michael T.
T1  - Genetic Diversity in the Common Morning Glory.
JO  - Plant Species Biology
JF  - Plant Species Biology
Y1  - 1996/04//
VL  - 11
IS  - 1
M3  - Article
SP  - 41
EP  - 50
SN  - 0913557X
AB  - Populations of the common morning glory in the southeastern US are characterized by a striking diversity of flower color polymorphisms. This diversity is probably a consequence of horticultural escapes from cultivation In the 18th and 19th centuries. More than 15 years of research in our laboratory has shown that some color phenotypes are selected by virtue of their differential attraction to Insect pollinators. We have studied genetic diversity at isozyme and ribosomal DNA loci and we find reduced diversity in the southeastern US compared to Mexican populations. In an effort to link ecological genetics to molecular evolution, we have cloned and characterized the chalcone synthase (CHS) gene family in morning glory and we have studied the expression of CHS genes in flower development. We have also initiated an investigation of spatial patterns of diversity at CHS genes by sampling and sequencing genes from US and Mexican populations. These investigations reveal (1) that the four CHS genes (CHS A, B, C, and PS) characterized to date evolve rapidly In morning glory and that the gene family In <em>Ipomoea</em> is of relatively recent origin (approximately 21 million years); (2) the duplicate genes in <em>Ipomoea</em> group into two categories (CHS A, C versus CHS B, PS) that may indicate a functional divergence between chalcone synthase and stilbene synthase activities; (3) levels of molecular diversity for CHS A genes sampled from Mexico are much higher than observed in US collections suggesting a major population bottleneck associated with the introduction of morning glory Into the southeastern US; and (4) the ratio of amino acid substitution to synonymous substitution between Ipomoea species is remarkably high (about 5.4 synonymous to amino acid substitutions) compared to CHS genes in other plant species. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Plant Species Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BIODIVERSITY
KW  - ECOLOGICAL heterogeneity
KW  - ISOENZYMES
KW  - RECOMBINANT DNA
KW  - GENETIC engineering
KW  - GENETIC recombination
KW  - chalcone synthase
KW  - Genetic diversity
KW  - isozyme.
KW  - rDNA
N1  - Accession Number: 13194029; Glover, Deborah Durbin, Mary L. 1 Huttley, Gavin 2 Clegg, Michael T. 1; Affiliation:  1: University of California, Department of Botany & Plant Sciences, Riverside, California 92521, U.S.A.  2: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research & Development Centers, Bldg. 560, Room 21-1015, Frederick, MD 21702, U.S.A.; Source Info: Apr96, Vol. 11 Issue 1, p41; Subject Term: BIODIVERSITY; Subject Term: ECOLOGICAL heterogeneity; Subject Term: ISOENZYMES; Subject Term: RECOMBINANT DNA; Subject Term: GENETIC engineering; Subject Term: GENETIC recombination; Author-Supplied Keyword: chalcone synthase; Author-Supplied Keyword: Genetic diversity; Author-Supplied Keyword: isozyme.; Author-Supplied Keyword: rDNA; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2015-38310-024
AN  - 2015-38310-024
AU  - Gallo, Vittorio
AU  - Zhou, Jia Min
AU  - McBain, Chris J.
AU  - Wright, Paul
AU  - Knutson, Peter L.
AU  - Armstrong, Regina C.
T1  - Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K+ channel block.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/04//
VL  - 16
IS  - 8
SP  - 2659
EP  - 2670
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gallo, Vittorio, Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A78, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38310-024. PMID: 8786442 Partial author list: First Author & Affiliation: Gallo, Vittorio; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Armstrong, Regina C. Major Descriptor: Glutamate Receptors; Neural Receptors; Neuroglia; Oligodendrocytes. Minor Descriptor: Animals; AMPA; Potassium Channel; Cell Migration. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Apr, 1996. Publication History: Accepted Date: Jan 24, 1996; Revised Date: Jan 17, 1996; First Submitted Date: Dec 8, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - We have analyzed the role of glutamate and its receptors (GluRs) in regulating the development of oligodendrocytes. Activation of AMPA- preferring GluRs with selective agonists inhibited proliferation of purified cortical oligodendrocyte progenitor (O-2A) cells cultured with different mitogens, as measured by [³H]thymidine incorporation or bromodeoxyuridine staining. In contrast, activation of GABA or muscarinic receptors did not affect O-2A proliferation. Cell viability and apoptosis assays demonstrated that the inhibition of O-2A proliferation was not attributable to a cytotoxic action of GluR agonists, and was reversible. Activation of GluRs prevented lineage progression from the O-2A (GD3+/nestin+) stage to the prooligodendroblast (O4+) stage, but did not affect O-2A migration. Additional experiments examined the membrane ionic channels mediating these GluR activation effects. We found that proliferating O-2A cells expressed functional delayed rectifier K+ channels, which were absent in pro-oligodendroblasts. GluR agonists and the K+ channel blocker tetraethylammonium (TEA) strongly inhibited delayed rectifier K+ currents in O-2A cells. TEA reproduced the effects of GluR activation on O-2A proliferation and lineage progression in the same concentration range that blocked delayed rectifier K+ currents. These results indicate that glutamate regulates oligodendrogenesis specifically at the O-2A stage by modulating K+ channel activity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - AMPA receptors
KW  - 0-2A cells
KW  - giia
KW  - cell migration
KW  - tetraethylammonium
KW  - delayed rectifier K’ channels
KW  - 1996
KW  - Glutamate Receptors
KW  - Neural Receptors
KW  - Neuroglia
KW  - Oligodendrocytes
KW  - Animals
KW  - AMPA
KW  - Potassium Channel
KW  - Cell Migration
KW  - 1996
U1  - Sponsor: Uniformed Service University of the Health Sciences (USUHS), US. Grant: RO70CB. Recipients: Armstrong, Regina C.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107379646
T1  - Seven-year trends in plasma low-density-lipoprotein-cholesterol in young adults: the CARDIA Study.
AU  - Bild DE
AU  - Jacobs DR Jr.
AU  - Liu K
AU  - Williams OD
AU  - Hilner JE
AU  - Perkins LL
AU  - Marcovina SM
AU  - Hulley SB
Y1  - 1996/05//1996 May
N1  - Accession Number: 107379646. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Supported by contracts N01-HC-48047-48050 and N01-HC-95095 from the National Heart, Lung, and Blood Institute, National Institutes of Health. NLM UID: 9100013. 
KW  - Lipoproteins, LDL Cholesterol -- In Adulthood
KW  - Lipoproteins, HDL Cholesterol -- In Adulthood
KW  - Triglycerides -- In Adulthood
KW  - Cholesterol -- In Adulthood
KW  - Funding Source
KW  - Time Factors
KW  - Race Factors
KW  - Sex Factors
KW  - Blacks
KW  - Whites
KW  - Body Mass Index
KW  - Body Weight
KW  - Diet, Atherogenic
KW  - Alcohol Drinking
KW  - Cardiovascular Risk Factors -- Trends
KW  - Epidemiological Research
KW  - Prospective Studies
KW  - T-Tests
KW  - Data Analysis, Statistical
KW  - Multiple Linear Regression
KW  - Data Analysis Software
KW  - McNemar's Test
KW  - Statistical Significance
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 235
EP  - 245
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 6
IS  - 3
CY  - New York, New York
PB  - Elsevier Science
AB  - To identify determinants of recent secular trends in lipids and characterize their influence on age-related increases in LDL-cholesterol, we examined a cohort of black and white men and women aged 18-30 in 1985-1986. Secular trends were determined by comparing participants aged 25-30 at baseline with those aged 25-30 at year 7 (2788 and 1395 participants, respectively). LDL-cholesterol was lower among those 25-30 at year 7 (5.9 to 10.2 mg/dL, depending on race-sex group; P < 0.001); weight was higher (8.3 to 12.5 lb; P < 0.001); Keys score was lower (-4.2 to - 7.3 units; P < 0.001); and use of oral contraceptives was greater (white women only, P < 0.01). Among 4086 participants followed for 7 years, LDL-cholesterol changed little or decreased, despite substantial weight increases in all groups (11.6 to 19.0 lb; P < 0.001). Keys scores decreased by 6.1 to 8.0 units, and use of oral contraceptives decreased (P < 0.001). Declining secular trends in LDL-cholesterol occurred despite upward trends in weight; the decline was associated with lower dietary fat and cholesterol and offset expected age-related increases in LDL-cholesterol.
SN  - 1047-2797
AD  - National Heart, Lung, and Blood Institute, Bethesda, MD
U2  - PMID: 8827159.
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DB  - rzh
ER  - 

TY  - JOUR
ID  - 107223047
T1  - Dietary calcium and blood pressure: a meta-analysis of randomized clinical trials.
AU  - Allender PS
AU  - Cutler JA
AU  - Follmann D
AU  - Cappuccio FP
AU  - Pryer J
AU  - Elliott P
Y1  - 1996/05//5/01/96
N1  - Accession Number: 107223047. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Blood Pressure -- Drug Effects
KW  - Calcium, Dietary -- Pharmacodynamics
KW  - Calcium, Dietary -- Administration and Dosage
KW  - Meta Analysis
KW  - Confidence Intervals
KW  - Spearman's Rank Correlation Coefficient
KW  - Linear Regression
SP  - 825
EP  - 831
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 124
IS  - 9
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 0003-4819
AD  - National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8610952.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - CONF
AU  - BUCHER, J. R.
AU  - PORTIER, C. J.
AU  - GOODMAN, J. I.
AU  - FAUSTMAN, E. M.
AU  - LUCIER, G. W.
T1  - National Toxicology Program Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/05//
VL  - 31
IS  - 1
M3  - Proceeding
SP  - 1
EP  - 8
PB  - Oxford University Press / USA
SN  - 02720590
AB  - A workshop entitled “NTP Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment” was held at the 34th Annual Meeting of the Society of Toxicology in Baltimore, Maryland. The purpose of the workshop was to provide an overview of factors currently considered important in the selection of doses for NTP studies, to describe some of the confounding factors that can result from the indiscriminate use of bioassay data in quantitative risk assessment, and to suggest ways in which information from mechanistic studies or studies of biomarkers of exposure or effect might be used to better advantage in risk assessment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Workshops (Adult education)
KW  - Meetings
KW  - Risk assessment -- Congresses
KW  - Toxicology -- Societies, etc.
KW  - Baltimore (Md.)
N1  - Accession Number: 82425549; BUCHER, J. R. 1,2,3; PORTIER, C. J. 1,2,3; GOODMAN, J. I. 2; FAUSTMAN, E. M. 3; LUCIER, G. W. 1,2,3; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; 2: Department of Pharmacology, Michigan State University East Lansing, Michigan 48824; 3: † Department of Environmental Health, University of Washington Seattle, Washington 98195; Issue Info: 1996, Vol. 31 Issue 1, p1; Subject Term: Workshops (Adult education); Subject Term: Meetings; Subject Term: Risk assessment -- Congresses; Subject Term: Toxicology -- Societies, etc.; Subject: Baltimore (Md.); Number of Pages: 8p; Document Type: Proceeding
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DP  - EBSCOhost
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ER  - 

TY  - JOUR
ID  - 107268514
T1  - Chemoprevention of breast cancer.
AU  - O'Shaughnessy JA
AU  - O'Shaughnessy, J A
Y1  - 1996/05//5/1/96
N1  - Accession Number: 107268514. Language: English. Entry Date: 19980701. Revision Date: 20161127. Publication Type: journal article; case study; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Chemoprevention
KW  - Breast Neoplasms -- Prevention and Control
KW  - Antineoplastic Agents -- Therapeutic Use
KW  - Female
KW  - Middle Age
KW  - Breast Neoplasms -- Familial and Genetic
KW  - Breast Neoplasms -- Therapy
KW  - Clinical Trials
KW  - Tumor Markers, Biological
SP  - 1349
EP  - 1353
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 275
IS  - 17
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md
U2  - PMID: 8614122.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Blauvelt, Andrew
AU  - Asada, Hideo
AU  - Klaus-Kovtun, Vera
AU  - Altman, David J.
AU  - Lucey, Daniel R.
AU  - Katz, Stephen I.
T1  - Interleukin-15 mRNA Is Expressed by Human Keratinocytes, Langerhans Cells, and Blood-Derived Dendritic Cells and Is Downregulated by Ultraviolet B Radiation.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/05//
VL  - 106
IS  - 5
M3  - Article
SP  - 1047
EP  - 1052
SN  - 0022202X
AB  - Interleukin (IL)-15 is a recently described cytokine that shares many functional activities with IL-2; however, unlike IL-2, IL-15 is produced by monocytes/ macrophages, and not by lymphocytes. In this report, we assessed IL-15 mRNA expression by freshly isolated human epidermal cells, as well as by negatively selected keratinocytes and positively selected Langerhans cells, utilizing reverse transcription and polymerase chain reaction. In addition, cultured keratinocytes, immortalized keratinocytes (HaCaT cells), and dendritic cells expanded from adult peripheral blood in the presence of granulocyte/macrophage-colony stimulating factor and IL-4 were examined for IL-15 transcripts. Using cultured keratinocytes, we also studied the regulation of IL-15 mRNA expression by ultraviolet B radiation <em>in vitro</em>. Freshly isolated keratinocytes, HaCaT cells, and cultured keratinocytes all constitutively expressed IL-15 mRNA, and IL-15 expression was downregulated by ultraviolet B radiation in cultured keratinocytes in a time- and dose-dependent manner. In addition, IL-15 transcripts were constitutively expressed by freshly isolated Langerhans cells and by adult blood-derived dendritic cells. IL-15 produced by keratinocytes, Langerhans cells, and other tissue-specific dendritic cells may be important in attracting and activating antigen-specific Th1 T cells. Furthermore, ultraviolet B-induced downregulation of keratinocyte IL-15 production may contribute to the relative state of immunosuppression induced by sun exposure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKINS
KW  - MESSENGER RNA
KW  - KERATINOCYTES
KW  - LYMPHOCYTES
KW  - LANGERHANS cells
KW  - DENDRITIC cells
KW  - epidermis
KW  - RT-PCR.
KW  - Th1
N1  - Accession Number: 12338641; Blauvelt, Andrew 1 Asada, Hideo 1 Klaus-Kovtun, Vera 1 Altman, David J. 1 Lucey, Daniel R. 2 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May96, Vol. 106 Issue 5, p1047; Subject Term: INTERLEUKINS; Subject Term: MESSENGER RNA; Subject Term: KERATINOCYTES; Subject Term: LYMPHOCYTES; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Author-Supplied Keyword: epidermis; Author-Supplied Keyword: RT-PCR.; Author-Supplied Keyword: Th1; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12338641
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - Fatherless America: Confronting Our Most Urgent Social Problem (Book).
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1996/05//
VL  - 58
IS  - 2
M3  - Book Review
SP  - 526
EP  - 527
SN  - 00222445
AB  - Reviews the book "Fatherless America: Confronting Our Most Urgent Social Problem," by David Blankenhorn.
KW  - SOCIAL problems
KW  - NONFICTION
KW  - BLANKENHORN, David
KW  - FATHERLESS America: Confronting Our Most Urgent Social Problem (Book)
N1  - Accession Number: 9606274191; Lamb, Michael E. 1; Affiliation:  1: National Institute of Child Health and Human Development.; Source Info: May96, Vol. 58 Issue 2, p526; Subject Term: SOCIAL problems; Subject Term: NONFICTION; Reviews & Products: FATHERLESS America: Confronting Our Most Urgent Social Problem (Book); People: BLANKENHORN, David; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 1185
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107337630
T1  - Identifying a neurobiologic basis for drug therapy in TMDs.
AU  - Denucci DJ
AU  - Dionne RA
AU  - Dubner R
Y1  - 1996/05//
N1  - Accession Number: 107337630. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; algorithm; pictorial; review. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Facial Pain -- Physiopathology
KW  - Facial Pain -- Drug Therapy
KW  - Temporomandibular Joint Syndrome -- Drug Therapy
KW  - Central Nervous System Agents -- Therapeutic Use
KW  - Antidepressive Agents -- Therapeutic Use
KW  - Antidepressive Agents -- Administration and Dosage
KW  - Antianxiety Agents, Benzodiazepine -- Therapeutic Use
KW  - Antianxiety Agents, Benzodiazepine -- Administration and Dosage
KW  - Adrenal Cortex Hormones -- Therapeutic Use
KW  - Analgesics, Nonnarcotic -- Therapeutic Use
KW  - Analgesics, Nonnarcotic -- Administration and Dosage
KW  - Analgesics, Nonnarcotic -- Adverse Effects
KW  - Analgesics, Opioid -- Therapeutic Use
KW  - Muscle Relaxants, Central -- Therapeutic Use
SP  - 581
EP  - 593
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 127
IS  - 5
CY  - Chicago, Illinois
PB  - American Dental Association
AB  - Emerging results from clinical and basic research indicate that persistent pain results in changes in the central nervous system. These changes may help explain chronic orofacial pain and lead to new therapies. The authors review data that support the use of tricyclic antidepressants for neurogenic or atypical pain, and benzodiazepines for musculoskeletal pain. Dentists must weigh the benefits of the chronic administration of a drug for the management of temporomandibular disorders against the equivocal scientific support for the use of many drug classes and the potential for serious toxicity with prolonged administration.
SN  - 0002-8177
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 1N-103, Bethesda, MD 20892
U2  - PMID: 8642138.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hill, Stuart A.
T1  - Limited variation and maintenance of tight genetic linkage characterize heteroallelic pilE recombination following DNA transformation of Neisseria gonorrhoeae.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/05//
VL  - 20
IS  - 3
M3  - Article
SP  - 507
EP  - 518
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Genetic recombination impacts on neisserial biology in two ways: (i) specific loci undergo rearrangement at high frequency leading to the formation of many different alleles; and (ii) <em>Neisseria</em>, being naturally competent for DNA transformation, provide a means to disseminate the novel alleles throughout a population. In this study <em>pilE</em> was used as a model system to examine heteroallelic recombination following DNA transformation. When gonococci were transformed with chromosomal donor DNA containing different <em>pilE</em> alleles, the majority of <em>pilE</em> recombinants arose through allelic replacement. Co-conversion analysis across <em>pilE</em> showed that in ∼85-90% of recombination events encompassing <em>pilE</em> and adjacent <em>opa</em> locus, linkage was maintained (i.e. ∼10-15% of recombination events terminated within the ∼1000 base pair <em>pilE/ opaE</em> interval). In addition to those recombinants that arose through allelic replacement, a large piius-minus subpopulation was also observed (∼10% of all recombinants), indicating that many recombination events did not yield recombinant <em>pilEs</em> that could be assembled into functional pili. <em>PilE</em> mosaics increased following transformation with plasmid donor DNAs carrying <em>pilE</em> with limited flanking-sequence homology, suggesting a potential role for flanking-sequence homologies in mosaic formation. Overall, the data support the view that horizontal transmission of chromosomal DNA between gonococci will favour the spread of intact alleles, as opposed to expanding the allelic repertoire through the formation of gene mosaics. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Homology (Biology)
KW  - Genetic recombination
KW  - Neisseria
KW  - Chromosomes
KW  - Mosaics (Genetics)
KW  - DNA
KW  - Plasmids
N1  - Accession Number: 21302397; Hill, Stuart A. 1; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; Issue Info: May1996, Vol. 20 Issue 3, p507; Thesaurus Term: Homology (Biology); Subject Term: Genetic recombination; Subject Term: Neisseria; Subject Term: Chromosomes; Subject Term: Mosaics (Genetics); Subject Term: DNA; Subject Term: Plasmids; Number of Pages: 12p; Illustrations: 3 Diagrams, 6 Charts; Document Type: Article
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ER  - 

TY  - JOUR
ID  - 107374567
T1  - Discard volumes necessary for clinically useful coagulation studies from heparinized HICKMAN catheters.
AU  - Mayo DJ
AU  - Dimond EP
AU  - Kramer W
AU  - Horne MK III
Y1  - 1996/05//1996 May
N1  - Accession Number: 107374567. Language: English. Entry Date: 19960701. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Blood Specimen Collection
KW  - Catheters, Vascular
KW  - Blood Coagulation Tests
KW  - Venipuncture
KW  - Heparin
KW  - Cancer Patients
KW  - Wilcoxon Signed Rank Test
KW  - Convenience Sample
KW  - Clinical Research
KW  - Descriptive Statistics
KW  - Prospective Studies
KW  - Comparative Studies
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Inpatients
KW  - Outpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 671
EP  - 675
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 23
IS  - 4
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - Purpose/Objectives: Determine the blood volume that must be wasted to obtain a clinically useful prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen concentration for blood drawn from a heparinized (2.5 ml of 100 units/ml), double-lumen venous catheter. Design: Prospective, nonrandomized study comparing test results obtained from blood samples drawn through the catheters with those obtained via peripheral venipuncture. Patients acted as their own control. Setting: Inpatient and outpatient units of a cancer research center located in a mid-Atlantic city in the United States. Sample: Twenty double-lumen 10 Fr. HICKMAN catheters (Bard Access Systems, Salt Lake City, UT) were studied in 20 adult patients with cancer who had no history of coagulation disorders. Methods: Samples were collected from the red lumen of 20 heparinized, double-lumen Hickman catheters after 5, 10, 15, 20, and 25 ml of blood first were discarded. PTs, APTTs, and fibrinogen concentrations were measured on each sample. The results were compared with those derived from a simultaneously obtained peripheral blood sample. Main Research Variables: PT, APTT, and fibrinogen values of blood samples after 5, 10, 15, 20, and 25 ml discards and PT, APTT, and fibrinogen of peripheral blood samples. Findings: The coagulation results using peripheral blood were always within the normal range except for one slightly elevated APTT. After 25 ml of discard, all of the PTs and fibrinogen concentrations and 95% of the APTTs of catheter blood were within the normal range and therefore clinically useful. Conclusions: Clinically useful PTs, APTTs, and fibrinogen concentrations often can be derived with catheter-drown blood when the objective is to confirm normal coagulution. However, because it is very difficult to obtain heparin-free samples through heparinized, double-lumen Hickman catheters, peripheral blood should be drown for coagulation testing when a totally heparin-free sample is needed to make a critical clinical decision. Implications tor Nursing Practice: These findings provide important information for practice when nurses hove to decide whether to draw coagulation tests through a heparinized catheter. Further research is needed with larger samples in varied populations (e.g., pediatrics) to study catheters made of different materials and of different calibers.
SN  - 0190-535X
AD  - Critical Care, Heart, Lung, Blood, and Cancer Nursing Service, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
U2  - PMID: 8735325.
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ER  - 

TY  - JOUR
T1  - Overnight Heart Rate and Cardiac Function in Patients with Dual Chamber Pacemakers.
AU  - Chew, Paul H.
AU  - Bush, David E.
AU  - Engel, Bernard T.
AU  - Talan, Mark I.
AU  - Abell, R. Tracy
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
Y1  - 1996/05//
VL  - 19
IS  - 5
SP  - 822
EP  - 828
SN  - 01478389
N1  - Accession Number: 17571301; Author: Chew, Paul H.: 1,2,3 Author: Bush, David E.: 2 Author: Engel, Bernard T.: 1 Author: Talan, Mark I.: 1 Author: Abell, R. Tracy: 2 ; Author Affiliation: 1 Laboratory of Behavioral Sciences, National Institute of Aging, National Institutes of Health, Gerontology Research Center: 2 Division of Cardiology, Johns Hopkins Bayview Medical Center, Johns University, Baltimore, Maryland: 3 Bristol-Myers Squibb Co., Pharmaceutical Research Institute, New Jersey; No. of Pages: 7; Language: English; Publication Type: Article; Update Code: 20050712
N2  - Animal data indicate that chronic, overnight pacing at normal evening heart rates impairs cardiac function. We examined the relationship of pacing rate and cardiac function in nine patients with dual-chamber pacemakers. We investigated two, 3-week pacing regimens (80 and 50 ppm: DDD mode) in a cross-over design. Doppler echocardiograms were performed at 1700 hours (PM) and 0600 hours (AM) at the end of each regimen. Ventricular function and preload decreased overnight (PM vs AM) with both pacing regimens. Compared to the morning values, the ratio of preejection to ejection time (PEP/ET) rose (0.43 vs 0.46), while the mean velocity of circumferential fiber shortening (Vcf) fell (1.16 cm/s vs 1.11 cm/s). Stroke volume (SV) (61 mL vs 53 mL) and ejection fraction (EF) also fell (0.56 vs 0.53) in the morning. End-diastolic volume (EDV) (94 mL vs 88 mL) decreased in the morning, as did the ratio of passive to active filling (E/A) (1.06 vs 0.96). Isovolumic relaxation time (91 ms vs 101 ms) increased overnight at both pacing rates. Systolic function decreased at 80 ppm relative to 50 ppm at both times of day. SV fell (54 mL vs 61 mL), while both EDV (92 mL vs 90 mL) and end-systolic volume (EDV) increased (43 mL vs 40 mL). Contractility measured by Vcf (1.09 cm/s vs 1.18 cm/s) and PEP/ET (0.49 vs 0.41) was reduced at 80 ppm. The heart needs to rest at night by slowing its rate of contraction. Pacing at 80 ppm impairs systolic and diastolic ventricular function compared to 50 ppm. Longer term consequences of ostensibly physiological pacing rates merit inquiry, particularly in those with preexisting cardiac dysfunction. ABSTRACT FROM AUTHOR
KW  - *CARDIAC pacemakers
KW  - *IMPLANTED cardiovascular instruments
KW  - *HEART beat
KW  - *HEART
KW  - *CARDIAC pacing
KW  - *CARDIOLOGY
KW  - circadian
KW  - heart failure
KW  - heart rate
KW  - pacemaker artificial
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ER  - 

TY  - JOUR
ID  - 107378283
T1  - The role of psychosocial factors in chronic obstructive pulmonary disease.
AU  - Czajkowski SM
AU  - McSweeny AJ
Y1  - 1996/05//1996 May
N1  - Accession Number: 107378283. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 9102787. 
KW  - Pulmonary Disease, Chronic Obstructive -- Psychosocial Factors
KW  - Pulmonary Disease, Chronic Obstructive -- Rehabilitation
KW  - Quality of Life
KW  - Behavior Modification
KW  - Rehabilitation, Pulmonary
KW  - Dyspnea -- Prevention and Control
KW  - Coping
KW  - Depression
KW  - Anxiety
KW  - Self-Efficacy
SP  - 341
EP  - 352
JO  - Physical Medicine & Rehabilitation Clinics of North America
JF  - Physical Medicine & Rehabilitation Clinics of North America
JA  - PHYS MED REHABIL CLIN NORTH AM
VL  - 7
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 1047-9651
AD  - Behavioral Medicine Research Group, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Two Rockledge Center, Rm 8124, 6701 Rockledge Dr, MSC 7936, Bethesda, MD 20892-7936
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107352946
T1  - Fungal infections: a growing threat.
AU  - Dixon DM
AU  - McNeil MM
AU  - Cohen ML
AU  - Gellin BG
AU  - La Lontagne JR
Y1  - 1996/05//May/Jun96
N1  - Accession Number: 107352946. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - Immunocompromised Host
KW  - Mycoses -- Prevention and Control
KW  - Opportunistic Infections -- Prevention and Control
KW  - Mycoses -- Epidemiology
KW  - Mycoses -- Etiology
KW  - Opportunistic Infections -- Etiology
KW  - Opportunistic Infections -- Epidemiology
KW  - Risk Factors
KW  - United States
KW  - Public Health
KW  - Drug Resistance
KW  - Disease Surveillance
SP  - 226
EP  - 235
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 111
IS  - 3
PB  - Sage Publications Inc.
AB  - The emergence of newly identified fungal pathogens and the reemergence of previously uncommon fungal diseases is primarily related to increases in the numbers of susceptible persons: people with HIV infection, bone marrow and organ transplant recipients, cancer patients being treated with chemotherapy, critically ill persons, and very low birth weight ( < or = 1500 g) infants. These immunocompromised populations are at risk for infection not only with opportunistic pathogens (for example, Pneumocystis, Candida, Cryptococcus, Trichosporon, Malassezia, Aspergillus, Penicillium marneffei, and numerous other moulds or yeasts) but also with fungal pathogens that usually infect otherwise healthy persons not previously exposed to endemic fungi (for example, Coccidioides immitis, Histoplasma capsulatum, and Blastomyces dermatitidis) and Sporothrix schenckii. Morbidity, mortality, and health care costs associated with fungal infections are high. Addressing the emergence of fungal diseases will require increased surveillance coupled with the availability of rapid, noninvasive diagnostic tests; monitoring the development of resistance to antifungal agents; and research focused on the understanding, prevention, and control of fungal infections.
SN  - 0033-3549
AD  - NIH/NIAD, 6003 Executive Blvd., Bethesda, MD 20892; e-mail dd24a@nih.gov
U2  - PMID: 8643813.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00874-001
AN  - 2006-00874-001
AU  - Baker, Ross A.
AU  - Herkenham, Miles
AU  - Brady, Linda S.
T1  - Effects of long-term treatment with antidepressant drugs on proopiomelanocortin and neuropeptide Y mRNA expression in the hypothalamic arcuate nucleus of rats.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1996/05//
VL  - 8
IS  - 5
SP  - 337
EP  - 343
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - Herkenham, Miles, Section on Functional Neuroanatomy, National Institute of Mental Health, Bldg. 36, Rm. 2D-15, Bethesda, MD, US, 20892
N1  - Accession Number: 2006-00874-001. PMID: 8736433 Partial author list: First Author & Affiliation: Baker, Ross A.; Section on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Gene Expression; Hypothalamus; Neuropeptide Y; Rats. Minor Descriptor: Ribonucleic Acid; mRNA. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: May, 1996. 
AB  - Antidepressant drugs have in common a delayed onset of clinical efficacy. In rats, long-term, daily administration of four different types of clinically effective antidepressant drugs results in decreased corticotropin releasing hormone (CRH) mRNA expression levels in the hypothalamic paraventricular nucleus (PVN). Because a subpopulation of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (Arc) projects to the PVN, we measured NPY and POMC mRNA expression in the Arc using in situ hybridization histochemistry at several time points following daily administration of four different antidepressant drugs. After 14 and 56 days of imipramine treatment, Arc NPY mRNA levels are decreased to 85% and 75% of control levels, but are unchanged compared to control after one or five days of treatment. Arc POMC mRNA levels are unchanged compared to controls at 1, 5, 14, or 56 days following imipramine treatment. Unlike after imipramine, Arc NPY and POMC mRNA levels are increased significantly to 134-172% of control following 56-day treatment with the antidepressant drugs fluoxetine, phenelzine, or idazoxan. The divergent effects of imipramine vs the other 3 antidepressant drugs on Arc NPY mRNA expression are similar to the pattern of changes in tyrosine hydroxylase (TH) mRNA expression levels in the locus coeruleus (LC) using the same experimental paradigm, but are different from the unidirectional depressive effects of all four drugs on CRH mRNA expression in the PVN. Thus, the Arc NPY and LC noradrenergic systems may act coordinately in mediating antidepressant effects. The present data are consistent with the delayed onset of clinical efficacy for antidepressant drugs, and suggest that Arc NPY and POMC neurotransmitter systems play a role in the pathophysiology of depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - rats
KW  - antidepressant drugs
KW  - proopiomelanocortin
KW  - neuropeptide Y
KW  - mRNA expression
KW  - hypothalamic arcuate nucleus
KW  - 1996
KW  - Antidepressant Drugs
KW  - Gene Expression
KW  - Hypothalamus
KW  - Neuropeptide Y
KW  - Rats
KW  - Ribonucleic Acid
KW  - mRNA
KW  - 1996
DO  - 10.1046/j.1365-2826.1996.04422.x
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UR  - ORCID: 0000-0003-2228-4238
UR  - 
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38311-005
AN  - 2015-38311-005
AU  - Liu, Qi-Ying
AU  - Schaffner, Anne E.
AU  - Li, Yong-Xin
AU  - Dunlap, Veronica
AU  - Barker, Jeffety L.
T1  - Upregulation of GABAA current by astrocytes in cultured embryonic rat hippocampal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/05//
VL  - 16
IS  - 9
SP  - 2912
EP  - 2923
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Liu, Qi-Ying, Laboratory of Neurophysiology, NINDS, National Institutes of Health, Building 36/Roam 2C02, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38311-005. PMID: 8622122 Partial author list: First Author & Affiliation: Liu, Qi-Ying; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160505. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gamma Aminobutyric Acid Agonists; Hippocampus; Neurons; Astrocytes. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: May, 1996. Publication History: Accepted Date: Feb 14, 1996; Revised Date: Feb 12, 1996; First Submitted Date: Dec 15, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - Embryonic rat hippocampal neurons were cultured on poly-D-lysine (PDL) or a monolayer of postnatal cortical astrocytes to reveal putative changes in neuronal physiology that involve astrocyte-derived signals during the first 4 d of culture. GABA-induced Cl− current (IGABA) was quantified using outside-out and whole-cell patch-clamp recordings beginning at 30 min, when cells had become adherent. The amplitude and density (current normalized to membrane capacitance) of IGABA in neurons grown on astrocytes became statistically greater than that recorded in neurons grown on PDL after 2 hr in culture (HIC). Although the current density remained unchanged in neurons on astrocytes, that in neurons on PDL decreased and became statistically lower beginning after 2 HIC. The differences in amplitude and density of IGABA in the two groups of neurons were maintained during the 4 d experiment. The upregulation effect of astrocytes on neuronal IGABA required intimate contact between the neuronal cell body and underlying astrocytes. Suppression of spontaneous Cac2+ elevations in astrocytes by bis(2-aminophenoxy)ethane-N,N,N′,N′-tetra-acetic acid that was loaded intracellularly decreased their modulatory effects on IGABA. IGABA in all cells was blocked completely by bicuculline and exhibited virtually identical affinity constants, Hill coefficients, and potentiation by diazepam in the two groups. Outside-out patch recordings revealed identical unitary properties of IGABA in the two groups. More channels per unit of membrane area could explain the astrocyte enhancement of IGABA. The results reveal that cortical astrocytes potentiate IGABA in hippocampal neurons in a contact-dependent manner via a mechanism involving astrocyte Cac2+ elevation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GABA receptor
KW  - ion channels
KW  - neuronal development
KW  - astrocyte
KW  - intracellular calcium
KW  - hippocampus
KW  - rat
KW  - 1996
KW  - Gamma Aminobutyric Acid Agonists
KW  - Hippocampus
KW  - Neurons
KW  - Astrocytes
KW  - Rats
KW  - 1996
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Basta, M.
T1  - Modulation of complement-mediated immune damage by intravenous immune globulin.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1996/05/02/May1996 Supplement
VL  - 104
M3  - Article
SP  - 21
EP  - 25
PB  - Wiley-Blackwell
SN  - 00099104
AB  - High-dose intravenous immune globulin (IVIG) exerts a beneficial effect in a variety of immune disorders. One possible underlying mechanism of this effect could be interference with the complement system. This conclusion was based on the results obtained in animal models of complement-mediated pathology, in vitro complement assays and studies on related human diseases. Clearance of IgM-sensitized erythrocytes was specifically suppressed by IVIG treatment. The same therapy prevented pulmonary endothelial cell lesions, the hallmark of Forssman shock, in 75% of animals, All control animals, either untreated or injected with control reagents, died within minutes following induction of Forssman shock. In vitro uptake of C3b and C4b complement fragments on to corpusculate immune complexes was significantly inhibited by IVIG. Studies that involved patients. suffering from disorders with pathogenesis similar to animal models of complement-mediated immune injury fully supported the hypothesis that IVIG interacts with activated complement components and prevents their deposition on target cells. The author's results suggest that IVIG can be an effective modulator of inappropriate complement attack. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COMPLEMENT deficiency (Immunology)
KW  - IMMUNOLOGIC diseases
KW  - COMPLEMENT (Immunology)
KW  - IMMUNOGLOBULINS
KW  - INTRAVENOUS therapy
KW  - CELLULAR pathology
KW  - complement
KW  - immune globulin therapy
KW  - immunomodulation
N1  - Accession Number: 16196448; Basta, M. 1; Affiliation:  1: Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: May1996 Supplement, Vol. 104, p21; Subject Term: COMPLEMENT deficiency (Immunology); Subject Term: IMMUNOLOGIC diseases; Subject Term: COMPLEMENT (Immunology); Subject Term: IMMUNOGLOBULINS; Subject Term: INTRAVENOUS therapy; Subject Term: CELLULAR pathology; Author-Supplied Keyword: complement; Author-Supplied Keyword: immune globulin therapy; Author-Supplied Keyword: immunomodulation; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Young, N. S.
T1  - Parvovirus infection and its treatment.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1996/05/02/May1996 Supplement
VL  - 104
M3  - Article
SP  - 26
EP  - 30
PB  - Wiley-Blackwell
SN  - 00099104
AB  - B19 parvovirus is an important pathogen in man. Acute infection produces fifth disease (erythema infectiosum) in normal individuals, transient aplastic crisis in the patient with haemolysis, and pure red cell aplasia in the immunologically incompetent host. Fetal infection can lead to hydrops fetalis. The target cell of the virus is the marrow erythroid progenitor. The immune response to the virus is largely humoral and directed against limited numbers of epitopes. Persistent infection is due to failure to produce neutralizing antibodies. Because viral infection is prevalent in the population, therapeutic immune globulin preparations are a good source of anti-B 19 antibodies. IgG administration can lead to cure of anaemia in the congenitally immunodeficient patient and to its amelioration in AIDS patients with persistent parvovirus infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ERYTHEMA
KW  - PURE red cell aplasia
KW  - ERYTHROCYTE disorders
KW  - AIDS patients
KW  - ANTIGENIC determinants
KW  - IMMUNOGLOBULIN G
KW  - IMMUNE response -- Molecular aspects
KW  - fifth disease immunodeficiency
KW  - immune globulin
KW  - red cell aplasia
KW  - sickle cell disease
N1  - Accession Number: 16196454; Young, N. S. 1; Affiliation:  1: Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.; Source Info: May1996 Supplement, Vol. 104, p26; Subject Term: ERYTHEMA; Subject Term: PURE red cell aplasia; Subject Term: ERYTHROCYTE disorders; Subject Term: AIDS patients; Subject Term: ANTIGENIC determinants; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNE response -- Molecular aspects; Author-Supplied Keyword: fifth disease immunodeficiency; Author-Supplied Keyword: immune globulin; Author-Supplied Keyword: red cell aplasia; Author-Supplied Keyword: sickle cell disease; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dalakas, M. C.
T1  - Clinical benefits and immunopathological correlates of intravenous immune globulin in the treatment of inflammatory myopathies.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1996/05/02/May1996 Supplement
VL  - 104
M3  - Article
SP  - 55
EP  - 60
PB  - Wiley-Blackwell
SN  - 00099104
AB  - High-dose intravenous immune globulin (IVIG) is emerging as a promising therapy for patients with inflammatory myopathies who have become unresponsive to, or cannot tolerate, conventional therapies. In a double-blind, placebo-controlled study, using objective criteria for improvement, IVIG demonstrated moderate to dramatic improvement in 75% of the patients with dermatomyositis. Preliminary results from a controlled study in inclusion-body myositis show that IVIG may also exert a mild benefit, but only in a small number of patients and in certain muscle groups. In some patients with polymyositis, IVIG is reported to be of benefit but controlled studies have not yet been completed. Immunocytochemical, immunological and in vitro studies on the patients' repeated muscle biopsies and follow-up sera showed that IVIG exert its action in inflammatory myopathies by: (i) inhibiting myotoxic cytokines, such as TNF-α and IL-1; (ii) blockade of Fc receptors on endomysial macrophages interfering with Fc receptor-mediated phagocytosis; and (iii) inhibiting the uptake of C3 and intercepting the formation and deposition of membranolytic attack complex on the endomysial capillaries. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - INTRAVENOUS therapy
KW  - MUSCLES -- Diseases
KW  - DERMATOMYOSITIS
KW  - IMMUNE response
KW  - PLACEBOS (Medicine)
KW  - IMMUNOPATHOLOGY
KW  - dermatomyositis
KW  - inclusion-body myositis
KW  - inflammatory myopathies
KW  - intravenous immune globulin
KW  - polymyositis
N1  - Accession Number: 16196486; Dalakas, M. C. 1; Affiliation:  1: Neuromuscular Diseases Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: May1996 Supplement, Vol. 104, p55; Subject Term: IMMUNOGLOBULINS; Subject Term: INTRAVENOUS therapy; Subject Term: MUSCLES -- Diseases; Subject Term: DERMATOMYOSITIS; Subject Term: IMMUNE response; Subject Term: PLACEBOS (Medicine); Subject Term: IMMUNOPATHOLOGY; Author-Supplied Keyword: dermatomyositis; Author-Supplied Keyword: inclusion-body myositis; Author-Supplied Keyword: inflammatory myopathies; Author-Supplied Keyword: intravenous immune globulin; Author-Supplied Keyword: polymyositis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Quinn, Thomas C.
T1  - Association of sexually transmitted diseases and infection with the human immunodeficiency virus: biological cofactors and markers of behavioural interventions.
JO  - International Journal of STD & AIDS
JF  - International Journal of STD & AIDS
Y1  - 1996/05/02/May1996 Supplement 2
VL  - 7
M3  - Article
SP  - 17
EP  - 24
PB  - Sage Publications, Ltd.
SN  - 09564624
AB  - The article presents a study on the factors and indicators of behavioral interventions in cases of sexually transmitted diseases (STD) and infection with HIV. It discusses results of some international studies regarding the association of STD and HIV. Factors of these cases are known to have been identified with multiple partners, commercial sex and other sexual activities.
KW  - HIV (Viruses)
KW  - Sexually transmitted diseases
KW  - Sex industry
KW  - Sexual intercourse
KW  - Human sexuality
N1  - Accession Number: 22201817; Quinn, Thomas C. 1,2; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; 2: Johns Hopkins University School of Medicine Baltimore, Maryland, USA; Issue Info: May1996 Supplement 2, Vol. 7, p17; Thesaurus Term: HIV (Viruses); Subject Term: Sexually transmitted diseases; Subject Term: Sex industry; Subject Term: Sexual intercourse; Subject Term: Human sexuality; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
L3  - 10.1258/0956462961917735
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105853010
T1  - Weight change between age 50 years and old age is associated with risk of hip fracture in white women aged 67 years and older.
AU  - Langlois JA
AU  - Harris T
AU  - Looker AC
AU  - Madans J
Y1  - 1996/05/13/
N1  - Accession Number: 105853010. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440. 
KW  - Hip Fractures -- Etiology
KW  - Weight Gain
KW  - Weight Loss
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and Over
KW  - Alcohol Drinking
KW  - Female
KW  - Middle Age
KW  - Risk Factors
KW  - Smoking
KW  - Whites
KW  - Human
SP  - 989
EP  - 994
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
JA  - ARCH INTERN MED
VL  - 156
IS  - 9
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0003-9926
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Md, USA.
U2  - PMID: 8624179.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107293632
T1  - Relative weight, weight change, height, and breast cancer risk in Asian-American women.
AU  - Ziegler RG
AU  - Hoover RN
AU  - Nomura AMY
AU  - West DW
AU  - Wu AH
AU  - Pike MC
AU  - Lake AJ
AU  - Horn-Ross PL
AU  - Kolonel LN
AU  - Siiteri PK
AU  - Fraumeni JF Jr.
Y1  - 1996/05/15/
N1  - Accession Number: 107293632. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Ethnology
KW  - Asians -- United States
KW  - Body Height
KW  - Body Weight
KW  - Adipose Tissue
KW  - Breast Neoplasms -- Etiology
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Case Control Studies
KW  - Risk Factors
KW  - Questionnaires
KW  - Weight Gain
KW  - Weight Loss
KW  - Multivariate Analysis
KW  - Relative Risk
KW  - Logistic Regression
KW  - Age Factors
KW  - Interviews
KW  - Philippines
KW  - Japan
KW  - China
KW  - United States
KW  - Human
SP  - 650
EP  - 660
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 10
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, Executive Plaza North, Rm 443, Bethesda, MD 20892-7374
U2  - PMID: 8627641.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107293632&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107259885
T1  - Dietary protein and blood pressure.
AU  - Obarzanek E
AU  - Velletri PA
AU  - Cutler JA
AU  - Obarzanek, E
AU  - Velletri, P A
AU  - Cutler, J A
Y1  - 1996/05/22/
N1  - Accession Number: 107259885. Language: English. Entry Date: 19980501. Revision Date: 20161112. Publication Type: journal article; research; review; tables/charts. Commentary: Lenfant C. High blood pressure: some answers, new questions, continuing challenges. (JAMA) 5/22/96; 275 (20): 1604-1606. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Dietary Proteins
KW  - Blood Pressure
KW  - Literature Review
KW  - Nonexperimental Studies
KW  - Experimental Studies
KW  - Restricted Diet
KW  - Dietary Proteins -- Adverse Effects
KW  - Dietary Proteins -- Pharmacodynamics
KW  - Human
SP  - 1598
EP  - 1603
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 275
IS  - 20
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: - To review published and presented data on the relationship between dietary protein and blood pressure in humans and animals.Data Sources: - Bibliographies from review articles and books on diet and blood pressure that had references to dietary protein. The bibliographies were supplemented with computerized MEDLINE search restricted to English language and abstracts presented at epidemiologic meetings.Study Selection: - Observational and intervention studies in humans and experimental studies in animals.Data Extraction: - In human studies, systolic or diastolic blood pressure were outcome measures, and dietary protein was measured by dietary assessment methods or by urine collections. In animal studies, blood pressure and related physiological effects were outcome measures, and experimental treatment included protein or amino acids.Data Synthesis: - Historically, dietary protein has been thought to raise blood pressure; however, studies conducted in Japan raised the possibility of an inverse relationship. Data analyses from subsequent observational studies in the United States and elsewhere have provided evidence of an inverse relationship between protein and blood pressure. However, intervention studies have mostly found no significant effects of protein on blood pressure. Few animal studies have specifically examined the effects of increased dietary protein on blood pressure.Conclusions: - Because of insufficient data and limitations in previous investigations, better controlled and adequately powered human studies are needed to assess the effect of dietary protein on blood pressure. In addition, more research using animal models, in which experimental conditions are highly controlled and detailed mechanistic studies can be performed, is needed to help provide experimental support for or against the protein-blood pressure hypothesis.
SN  - 0098-7484
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892-7936, USA
AD  - National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, 2 Rockledge Centre, MSC 7436, 6701 Rockledge Dr., Room 8136, Bethesda, MD 20892-7936
U2  - PMID: 8622252.
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DP  - EBSCOhost
DB  - rzh
ER  - 

ID  - 107312534
T1  - Chronic viral hepatitis--benefits of current therapies.
AU  - Hoofnagle JH
AU  - Lau D
AU  - Hoofnagle, J H
AU  - Lau, D
Y1  - 1996/05/30/
N1  - Accession Number: 107312534. Language: English. Entry Date: 19970201. Revision Date: 20161127. Publication Type: editorial; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Hepatitis B -- Drug Therapy
KW  - Hepatitis C -- Drug Therapy
KW  - Chronic Disease -- Drug Therapy
SP  - 1470
EP  - 1471
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 334
IS  - 22
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institute of Diabetes of Digestive and Kidney Diseases, Bethesda, MD 20892
U2  - PMID: 8618588.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107312534&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Baird, Donna Day
AU  - Weinberg, Clarice R.
AU  - Voigt, Lynda F.
AU  - Daling, Janet R.
T1  - Vaginal Douching and Reduced Fertility.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/06//
VL  - 86
IS  - 6
M3  - Article
SP  - 844
EP  - 844
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study investigated douching and reduced fertility. Methods. The monthly probability of conception for douchers and nondouchers was compared in a sample of 840 married, parous women in King County, Washington. Data on the number of months required to conceive were analyzed. Results. In comparison with non-douchers, women who douched were 30% less likely to become pregnant each month they attempted pregnancy. This relationship remained after adjustment for covariates, and it could not be explained by women douching for medical reasons. The reduction was not related to the type of douching preparation used. Young women who douched had significantly greater reductions in monthly fertility than older women (50% reduction for women 18 to 24 years old, 29% reduction for women 25 to 29 years old, and 6% reduction for women 30 to 39 years old). conclusions. Douching was associated with reduced fertility. Further research is needed to determine whether the relationship is causal and, if so, to what extent it is mediated by pelvic infection. In the meantime, women should be informed that douching may have adverse effects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FERTILITY
KW  - CONTRACEPTION
KW  - PREGNANCY
KW  - WOMEN
KW  - WASHINGTON (State)
N1  - Accession Number: 9607016051; Baird, Donna Day 1 Weinberg, Clarice R. 1 Voigt, Lynda F. 2 Daling, Janet R. 2; Affiliation:  1: Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, N.C.  2: Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle; Source Info: Jun96, Vol. 86 Issue 6, p844; Subject Term: FERTILITY; Subject Term: CONTRACEPTION; Subject Term: PREGNANCY; Subject Term: WOMEN; Subject Term: WASHINGTON (State); Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Lutter, Chessa
AU  - Pérez-Escamilta, Rafael
AU  - Gladen, Beth C.
AU  - Rogan, Walter J.
T1  - DDE and insufficient breast milk.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/06//
VL  - 86
IS  - 6
M3  - Letter
SP  - 887
EP  - 887
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor is presented in response to the article "DDE and Shortened Durations of Lactation in a Northern Mexican Town," by B. C. Gladen and W. J. Rogan in the 1995 issue of the "American Journal of Public Health," including a response from the authors.
KW  - LETTERS to the editor
KW  - BREASTFEEDING (Humans)
N1  - Accession Number: 19893503; Lutter, Chessa 1 Pérez-Escamilta, Rafael 2 Gladen, Beth C. 3 Rogan, Walter J. 4; Affiliation:  1: Wellstart International, Washington, D.C.  2: Department of Nutritional Sciences, University of Connecticut, Storrs  3: Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, N.C.  4: Office of the Scientific Director, National Institute of Environmental Health Sciences, Research Triangle Park, N.C.; Source Info: Jun96, Vol. 86 Issue 6, p887; Subject Term: LETTERS to the editor; Subject Term: BREASTFEEDING (Humans); Number of Pages: 2/3p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107352727
T1  - Vaginal douching and reduced fertility.
AU  - Baird DD
AU  - Weinberg CR
AU  - Voigt LF
AU  - Daling JR
Y1  - 1996/06//
N1  - Accession Number: 107352727. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Data collection was supported by a contract (1 NO1 HD 02821) with the National Institute of Child Health and Human Development. NLM UID: 1254074. 
KW  - Fertility
KW  - Therapeutic Irrigation -- Adverse Effects
KW  - Pregnancy
KW  - Vagina
KW  - Age Factors
KW  - Comparative Studies
KW  - Therapeutic Irrigation -- Methods
KW  - Cox Proportional Hazards Model
KW  - Retrospective Design
KW  - Risk Factors
KW  - Funding Source
KW  - Case Control Studies
KW  - Record Review
KW  - Structured Interview
KW  - Washington
KW  - Descriptive Statistics
KW  - Multivariate Analysis
KW  - Confidence Intervals
KW  - Odds Ratio
KW  - Adolescence
KW  - Adult
KW  - Female
KW  - Human
SP  - 844
EP  - 850
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 86
IS  - 6
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study investigated douching and reduced fertility. METHODS: The monthly probability of conception for douchers and nondouchers was compared in a sample of 840 married, parous women in King County, Washington. Data on the number of months required to conceive were analyzed. RESULTS: In comparison with nondouchers, women who douched were 30% less likely to become pregnant each month they attempted pregnancy. This relationship remained after adjustment for covariates, and it could not be explained by women douching for medical reasons. The reduction was not related to the type of douching preparation used. Young women who douched had significantly greater reductions in monthly fertility than older women (50% reduction for women 18 to 24 years old, 29% reduction for women 25 to 29 years old, and 6% reduction for women 30 to 39 years old). CONCLUSIONS: Douching was associated with reduced fertility. Further research is needed to determine whether the relationship is casual and, if so, to what extent it is mediated by pelvic infection. In the meantime, women should be informed that douching may have adverse effects.
SN  - 0090-0036
AD  - Epidemiology Branch, MD A3-05, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709
U2  - PMID: 8659660.
DO  - 10.2105/AJPH.86.6.844
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DP  - EBSCOhost
DB  - rzh
ER  - 
TY  - JOUR
TY  - GEN
AU  - Green, L.;
T1  - Ethics and biogenetic engineering
CT  - Ethics and biogenetic engineering
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1996/06/01/
VL  - 53
IS  - Jun
SP  - PI
EP  - 75
AD  - National Institutes of Health, Clinical Center Pharmacy Department, 10 Center Dr., Rm. 1N257, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 33-05455; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics; Pharmaceutical Technology
N2  - Mapping the human genome will increase our ability to predict, understand, and eventually prevent or cure human diseases. The National Institutes of Health support activities that focus on anticipating issues arising from the application of the results of the Human Genome Project and on proposing solutions that will forestall adverse effects. This presentation will focus on the numerous social and ethical implications of this endeavor. The basic issues involve fairness in the use of genetic information. Privacy and confidentiality of genetic information is currently a topic of controversy. Human gene therapy has also driven us to consider its ethical implications. The potential ability to alter the strength, intelligence or personality of our offspring raise interesting and ethical dilemmas. Learning objectives: 1. Describe potential uses and misuses of genetic information 2. Describe the work of the Ethical, Legal, and Social Implications (ELSI) working group including its mission, areas of priority, concern, and particular importance. 3. Discuss the ELSI task force on genetic information and health insurance as a model that incorporates many of the issues of an ethical and social nature. 4. Describe the major issues involved in the ongoing ethical debate in human gene therapy. Self-assessment questions: 1. What is the primary ethical controversy over germ-line gene therapy? a. Decline in the number of female babies; b. Changing the genetic makeup of future generations; c. Discrimination of less than perfect babies; 2. Name ways genetic information can be misused. a. declining health insurance; b. job discrimination; c. social stigmatization; d. all of the above. 3. Genetic counseling may have an impact on which of the following areas: a. pre-natal testing; b. pre-symptomatic testing; c. carrier status testing; d. testing when there is no therapeutic remedy available; e. all of the above. Answers: 1. b; 2. d; 3. e.
KW  - ASHP meeting abstracts--ethics, genetic engineering;
KW  - Health benefit programs--third party--genetic discrimination;
KW  - National Institutes of Health--Ethical, Legal, and Social Implications Working Group--genetic engineering;
KW  - Genetic engineering--ethics--health care;
KW  - Human Genome Project--ethics--issues;
KW  - Patient information--confidentiality--genetic engineering;
KW  - Sociology--genetic engineering--ethics;
KW  - Gene therapy--health care--ethics;
KW  - Discrimination--genetic engineering--ethics;
KW  - Ethics--genetic engineering;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Piscitelli, S. C.;
T1  - Interleukins in the treatment of HIV infection
CT  - Interleukins in the treatment of HIV infection
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1996/06/01/
VL  - 53
IS  - Jun
SP  - PI
EP  - 63
AD  - Clinical Center Pharmacy Department, National Institutes of Health, Bldg. 10, Rm. 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 33-05423; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - Infection with the human immunodeficiency virus (HIV) is associated with a profound alteration in the production, function, and regulation of cytokines. The resulting immunologic defects provide a rationale for cytokine replacement, an alternative approach to treatment of HIV infection. Preclinical studies have demonstrated that replacement of various interleukins may reverse some of the immunologic abnormalities seen in late-stage disease. The largest amount of clinical experience lies with administration of recombinant interleukin-2, -4, -10 and -12. Although initial data appear promising, there are a variety of issues which require additional study including supportive care, duration, dose, viral activation, and long-term effects. This presentation will provide an insightful view of current and future cytokine use for management of HIV infection. Learning objectives: 1. Describe the rationale for the use of interleukins in the treatment of HIV infection. 2. Describe the effects of interleukin therapy on the progression of HIV infection. 3. Identify adverse effects of interleukins and describe their management. Self-assessment questions: 1. Which of the following describes the effects of interleukin-2 administration to patients with HIV infection? a. Decrease in viral burden; b. Increase in CD4 lymphocytes; c. Increase in patient survival; d. Increase in blood levels of antiretrovirals. 2. Which of the following are adverse effects of recombinant cytokines? a. Flu-like syndrome; b. Rash; c. Capillary leak syndrome; d. All of the above. 3. Which of the following may affect the pharmacokinetics of interleukins? a. Formulation; b. Route of administration; c. Duration of infusions; d. All of the above. Answers: 1. b; 2. d; 3. d.
KW  - ASHP meeting abstracts--interleukins;
KW  - Interleukins--HIV infections--therapy;
KW  - HIV infections--interleukins--therapy;
KW  - Pharmacokinetics--interleukins--HIV infections;
KW  - Toxicity--interleukins--side effects;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Green, L.;
T1  - Pharmacy issues in human gene therapy
CT  - Pharmacy issues in human gene therapy
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1996/06/01/
VL  - 53
IS  - Jun
SP  - PI
EP  - 17
AD  - National Institutes of Health, Clinical Center Pharmacy Department, 10 Center Dr., Rm. IN257, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 33-05353; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice; Legislation, Laws and Regulations
N2  - As human gene therapy moves from the laboratory to the clinics, pharmacists must be able to handle the diverse nature of gene therapy products in clinical use. Some of the unique problems of performing gene therapy protocol manipulations in a clinical setting include attention to detail and quality standards and may require a dedicated production site. Points to be considered when planning pharmaceutical services for clinical gene therapy protocols include path of transfer of materials, flexibility to meet future needs, and safety issues and regulatory guidelines. The concerns for the safety of the workers in a laboratory as well as the safety of the public must always be part of planning for gene therapy production and preparation facilities. Learning objectives: 1. Describe the safety issues involved in planning for gene therapy protocols. 2. Describe the regulatory issues involved in planning for gene therapy protocols. 3. Describe the types of gene therapy products that will most likely be seen by hospital pharmacies in the near future. Self-assessment questions: 1. The points to consider when designing a pharmacy area to be used for clinical gene therapy are: a. Functional adjacencies; b. Path of transfer; c. Safety issues; d. All of the above. 2. Sources of useful information when planning for gene therapy protocols include: a. Code of Federal Regulation; b. Biosafety in the Laboratory (NRC); c. Institutional Infection Control Office; d. NIH Guidelines for Recombinant DNA; e. All of the above. 3. Gene therapy products that are currently being tested in the clinical setting include: a. Gene altered cells; b. Gene altered tumor vaccines; c. Gene altered viral vectors; d. All of the above. Answers: 1. e; 2. e; 3. d.
KW  - ASHP meeting abstracts--gene therapy;
KW  - Gene therapy--clinical studies;
KW  - Clinical studies--drugs, investigational--gene therapy;
KW  - Drugs, investigational--clinical studies--gene therapy;
KW  - Pharmacy services--drugs, investigational--gene therapy;
KW  - Pharmacists, hospital--role--gene therapy;
KW  - Regulations--gene therapy;
KW  - Planning and design--hospital pharmacy--gene therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=33-05353&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107318716
T1  - The effects of frontal lobe damage on everyday problem solving.
AU  - Dimitrov M
AU  - Grafman J
AU  - Hollnagel C
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107318716. Language: English. Entry Date: 19970401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Wisconsin Card Sorting Test (WCST); Beck Depression Inventory (BDI); Wechsler Adult Intelligence Scale-Revised (WAIS-R); Tower of Hanoi (TOH); Everyday Problem Solving Inventory (EPSI); Neurobehavioral Rating Scale (Levin et al); Cornelius and Caspi's Inventory (Cornelius and Caspi). NLM UID: 0100725. 
KW  - Frontal Lobe -- Injuries
KW  - Problem Solving
KW  - Frontal Lobe -- Pathology
KW  - Dementia -- Physiopathology
KW  - Wounds, Penetrating -- Physiopathology
KW  - Neuropsychological Tests
KW  - Research Instruments
KW  - Correlation Coefficient
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 357
EP  - 366
JO  - Cortex: A Journal Devoted to the Study of the Nervous System & Behavior
JF  - Cortex: A Journal Devoted to the Study of the Nervous System & Behavior
JA  - CORTEX
VL  - 32
IS  - 2
PB  - Masson SPA
AB  - The prefrontal cortex plays an especially important role in human social-cognitive behavior. It has been difficult to quantify deficits in this domain in patients with frontal lobe lesions using standardized psychological instruments. We administered the Everyday Problem Solving Inventory (EPSI), which is composed of a range of scenarios depicting everyday social problems and their possible solutions, to a group of patients with frontal lobe lesions who were required to rate each of 4 possible solutions to each problem for their effectiveness. Our sample consisted of 27 normal controls (NCs), 33 patients with focal frontal lobe lesions (FLL), and 3 patients with frontal lobe dementia (FLD). The performance of the FLL patients on the EPSI instrument was also compared with their performance on traditional neuropsychological tests. The results indicated that the FLD patients' EPSI rank ordering of social problem solutions was uncorrelated with the performance of NCs and about half of the FLL patients EPSI rank orderings of solutions also varied substantially from those of the NCs. These same FLL patients also had the lowest scores, compared to FLL patients whose judgements on the EPSI were similar to that of the NCs, on a set of neuropsychological tasks sensitive to frontal lobe dysfunction. There was no obvious relationship between locus of lesion within the frontal lobes and performance on the EPSI. These results suggest that some patients with prefrontal lobe lesions may have impaired social judgement that can be directly revealed through the use of a conventional psychological inventory such as the EPSI.
SN  - 0010-9452
AD  - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8800621.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107318716&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107324395
T1  - Visual prognosis and sympathetic ophthalmia.
AU  - Ramadan A
AU  - Nussenblatt RB
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107324395. Language: English. Entry Date: 19970601. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9011108. 
KW  - Eye Injuries -- Complications
KW  - Eye Diseases
KW  - Eye Diseases -- Epidemiology
KW  - Eye Diseases -- Therapy
KW  - Eye Diseases -- Prognosis
SP  - 39
EP  - 45
JO  - Current Opinion in Ophthalmology
JF  - Current Opinion in Ophthalmology
JA  - CURR OPIN OPHTHALMOL
VL  - 7
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1040-8738
AD  - Building 10, Room 10N202, National Eye Institute, Laboratory of Immunology, National Institutes of Health, Bethesda, MD 20892-1858
U2  - PMID: 10163458.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107324395&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Umar, Asad
AU  - Kunkel, Thomas A.
T1  - DNA-replication fidelity, mismatch repair and genome instability in cancer cells.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1996/06//6/1/96
VL  - 238
IS  - 2
M3  - Article
SP  - 297
EP  - 307
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Examines how DNA is replicated with high fidelity and how defects in these processes can lead to a higher than normal mutation rate in cancer cells.  Key steps and principles for high fidelity replication; Observation of mutator phenotype in tumor cells; Germ line mutation in genes.
KW  - DNA replication
KW  - DNA synthesis
KW  - CANCER cells
KW  - MUTATION (Biology)
KW  - GENOMICS
KW  - BIOCHEMISTRY
N1  - Accession Number: 12246773; Umar, Asad 1 Kunkel, Thomas A. 1; Affiliation:  1: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, North Carolina, USA; Source Info: 6/1/96, Vol. 238 Issue 2, p297; Subject Term: DNA replication; Subject Term: DNA synthesis; Subject Term: CANCER cells; Subject Term: MUTATION (Biology); Subject Term: GENOMICS; Subject Term: BIOCHEMISTRY; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107351762
T1  - Granulocyte transfusions: time for a second look.
AU  - Chanock SJ
AU  - Gorlin JB
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107351762. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Neutropenia -- Therapy
KW  - Granulocytes
KW  - Blood Component Transfusion
KW  - Neutropenia -- Complications
KW  - Granulocyte Colony-Stimulating Factor -- Therapeutic Use
KW  - Blood Specimen Collection
SP  - 327
EP  - 343
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 10
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0891-5520
AD  - Pediatric Branch, 10/13N240, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 8803623.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107351762&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107351768
T1  - Recent progress and current problems in treatment of invasive fungal infections in neutropenic patients.
AU  - Walsh TJ
AU  - Hiemenz JW
AU  - Anaissie E
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107351768. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Neutropenia -- Complications
KW  - Mycoses -- Drug Therapy
KW  - Antifungal Agents -- Therapeutic Use
KW  - Antifungal Agents -- Administration and Dosage
KW  - Infection -- Etiology
KW  - Candidiasis -- Drug Therapy
KW  - Aspergillosis -- Drug Therapy
KW  - Fungemia -- Drug Therapy
KW  - Opportunistic Infections -- Drug Therapy
KW  - Amphotericin B -- Therapeutic Use
KW  - Cytokines -- Therapeutic Use
KW  - Recombinant Proteins -- Therapeutic Use
SP  - 365
EP  - 400
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 10
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0891-5520
AD  - Infectious Diseases Section, National Cancer Institute, Building 10, Room 13N-240, Bethesda, MD 20892
U2  - PMID: 8803625.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107351768&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Singer, Merrill
AU  - Needle, Richard
T1  - PREVENTING AIDS AMONG DRUG USERS: EVALUATING EFFICACY.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1996///Summer96
VL  - 26
IS  - 3
M3  - Article
SP  - 521
EP  - 523
SN  - 00220426
AB  - The article presents information on the Cooperative Agreement for AIDS Community-Based Outreach/Intervention Research of the U.S. National Institute on Drug Abuse. The research program aims to monitor risk factors and behaviors, rates of HIV prevalence and incidence among injection drug users and users of crack cocaine; evaluate the cost-effectiveness and cost-utility of interventions designed to prevent and reduce HIV risk behaviors and implement additional interventions to prevent the spread of HIV.
KW  - AIDS (Disease) -- Prevention
KW  - HIV infections
KW  - COST effectiveness
KW  - DRUG abuse
KW  - SUBSTANCE abuse
KW  - COMMUNITY health services
KW  - RESEARCH
KW  - UNITED States
KW  - NATIONAL Institute on Drug Abuse
N1  - Accession Number: 19413553; Singer, Merrill 1 Needle, Richard 2; Affiliation:  1: Hispanic Health Council  2: National Institute on Drug Abuse; Source Info: Summer96, Vol. 26 Issue 3, p521; Subject Term: AIDS (Disease) -- Prevention; Subject Term: HIV infections; Subject Term: COST effectiveness; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: COMMUNITY health services; Subject Term: RESEARCH; Subject Term: UNITED States; Company/Entity: NATIONAL Institute on Drug Abuse; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1372
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Trotter, Robert T.
AU  - Bowen, Anne M.
AU  - Baldwin, Julie A.
AU  - Price, Laurie J.
T1  - THE EFFICACY OF NETWORK-BASED HIV/AIDS RISK REDUCTION PROGRAMS IN MIDSIZED TOWNS IN THE UNITED STATES.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1996///Summer96
VL  - 26
IS  - 3
M3  - Article
SP  - 591
EP  - 605
SN  - 00220426
AB  - Combining current psychosocial theories with social network outreach and prevention paradigms is an effective mechanism for reducing both drug-related and sexual risks for HIV transmission in active drug users in mid-sized towns in the United States. Five hundred and seventy-nine individuals were recruited in two towns, one of 50,000 and one of 10,000 population. Three approaches to intervention were tested. These approaches included: (1) an intensive outreach program using indigenous outreach workers providing reinforcement of an HIV risk reduction program, and (2) a low intensity outreach program combined with a more intensive office-based HIV risk reduction program. Both conditions were compared with the National Institute on Drug Abuse (NIDA) recommended standard intervention. Each of the enhanced interventions produced a reduction in HIV-related risk taking reported by the participants. The intensive outreach combined with office intervention and the intensive office intervention without outreach reinforcement each produced significant reductions in sexual risk taking in active drug users, beyond the reductions reported for the NIDA standard program. The enhanced risk reduction programs produced differential impacts for males and females, respectively, between the two high and low intensity outreach models. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease) -- Prevention
KW  - HIV infections
KW  - HEALTH risk assessment
KW  - DRUG abuse
KW  - SUBSTANCE abuse
KW  - SOCIAL networks
KW  - HUMAN sexuality
KW  - UNITED States
KW  - NATIONAL Institute on Drug Abuse
N1  - Accession Number: 9611040211; Trotter, Robert T. 1,2,3,4,5 Bowen, Anne M. 6 Baldwin, Julie A. 7 Price, Laurie J. 8; Affiliation:  1: Arizona Regent's Professor, Department of Anthropology, Northern Arizona University  2: Principal investigator on grants, National Institute on Drug Abuse (NIDA)  3: Principal investigator on grants, National Institute of Mental Health (NIMH)  4: Consultant, World Health Organization  5: Director of the Arizona Comprehensive Ethnographic Research Training (ACERT) program  6: Assistant Professor, Department of Psychology, University of Wyoming  7: Assistant Professor, Department of Health, Physical Education, Exercise Science and Nutrition, Northern Arizona University  8: Associate Professor, Department of Anthropology, Northern Arizona University; Source Info: Summer96, Vol. 26 Issue 3, p591; Subject Term: AIDS (Disease) -- Prevention; Subject Term: HIV infections; Subject Term: HEALTH risk assessment; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: SOCIAL networks; Subject Term: HUMAN sexuality; Subject Term: UNITED States; Company/Entity: NATIONAL Institute on Drug Abuse; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 15p; Illustrations: 7 Charts; Document Type: Article; Full Text Word Count: 6184
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107273292
T1  - Psychosocial profiles of men and women with anginalike chest pain before and after retirement.
AU  - Knox SS
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107273292. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Peer Reviewed; USA. Instrumentation: Body Mass Index; Self-Administered Version of the London School of Hygiene Questionnaire. Grant Information: U.S. National Institute of Aging (AG-04563) and the Swedish Work Environment Fund. NLM UID: 9889882. 
KW  - Angina Pectoris -- Psychosocial Factors
KW  - Retirement
KW  - Stress, Occupational -- Adverse Effects
KW  - Sex Factors
KW  - Psychosocial Aspects of Illness
KW  - Body Mass Index
KW  - Coefficient Alpha
KW  - Health Status
KW  - Male
KW  - Female
KW  - Middle Age
KW  - Aged
KW  - Questionnaires
KW  - Sweden
KW  - Risk Factors
KW  - Employment
KW  - Twins
KW  - Work Environment
KW  - Factor Analysis
KW  - P-Value
KW  - One-Way Analysis of Variance
KW  - Multiple Logistic Regression
KW  - Odds Ratio
KW  - Chi Square Test
KW  - Coronary Prone Behavior
KW  - Funding Source
KW  - Human
SP  - 111
EP  - 124
JO  - Journal of Gender, Culture, & Health
JF  - Journal of Gender, Culture, & Health
JA  - J GENDER CULTURE HEALTH
VL  - 1
IS  - 2
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - The present study examined the extent to which behavioral and psychosocial factors were associated with anginalike chest pain before and after retirement. The subjects were Swedish twins who did not show heritability for angina. The results revealed differing psychosocial profiles in men and women with angina before and after retirement. In employed women under 65, smoking, overweight and Type A Behavior composite were associated with angina. In men under 65, work pressure and factory type work accompanied by smoking and a low degree of emotional well-being constituted the major risks. The profiles of men and women over 65 with angina differed markedly from the under 65 age group, but there was little gender variation. A diminished sense of health and well-being was a significant factor for both men and women in this age group, surpassing both smoking and body mass index in relative risk. Additional risk factors for older women were a low standard of living and low perception of personal health.
SN  - 1087-3201
AD  - The National Heart, Lung, and Blood Institute, II Rockledge Center, 6701 Rockledge Drive, Bethesda, Maryland 20892-7936
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107273292&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Thérond, Patrice
AU  - Gerbaud, Pascale
AU  - Dimon, Stéphanie
AU  - Anderson, Wayne B.
AU  - Evain-Brion, Danièle
AU  - Raynaud, Françoise
T1  - Antioxidant Enzymes in Psoriatic Fibroblasts and Erythrocytes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/06//
VL  - 106
IS  - 6
M3  - Article
SP  - 1325
EP  - 1331
SN  - 0022202X
AB  - Antioxidant enzyme activities in fibroblasts and erythrocytes prepared from normal and psoriatic patients were measured and compared. The most significant differences were noted in superoxide dismutase (SOD) activities. A dramatic (5.2-fold) increase in Mn-SOD activity along with a lesser (1.8-fold) increase in CuZn-SOD activity was observed in fibroblasts from lesional and nonlesional psoriatic skin. the increase of Mn-SOD activity was correlated with an increase of both protein and mRNA. A slight (1.2-fold) increase in CuZn-SOD activity was also found in psoriatic as compared to normal red blood cells, while Mn-SOD activity was not present in these cells. In contrast, both glutathione peroxidase and catalase activities were only slightly (1.3-fold) increased in psoriatic fibroblasts, with no appreciable change noted in psoriatic erythrocytes. Likewise, glutathione levels were observed to be similar in normal and psoriatic cells. The increases in SOD activities did not appear to correlate with the severity of the disease as expressed by the Psoriatic Area Severity Index score or with plasma inflammatory markers. These results demonstrate that antioxidant enzyme activities, particularly Mn-SOD in fibroblasts and CuZn-SOD in erythrocytes, are significantly elevated in cells from psoriatic patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PSORIASIS
KW  - FREE radicals (Chemistry)
KW  - FIBROBLASTS
KW  - ERYTHROCYTES
KW  - GLUTATHIONE
KW  - DERMATOLOGY
KW  - <em>erythrocytes</em>
KW  - <em>fibroblasts</em>
KW  - <em>free radicals</em>
KW  - <em>psoriasis</em>
KW  - <em>superoxide dismutases</em>
N1  - Accession Number: 12349055; Thérond, Patrice 1 Gerbaud, Pascale 2 Dimon, Stéphanie 2 Anderson, Wayne B. 3 Evain-Brion, Danièle 2 Raynaud, Françoise 2; Affiliation:  1: Service de Biochimie, Hôpital Bicêtre, 71 rue du Général Leclerc, 94 275 le Kremlin Bicêtre Cedex, France.  2: INSERM U 427, Développement Humain, Croissance et Différenciation, Faculté des Sciences Pharmaceutiques et Biologiques de paris, Université René Descartes, Paris V, 4 avenue de l'Observatorie, 75270 Paris Cedex 06, France.  3: Laboratory of Cellular Oncology, National Cancer, Institute, National Institutes of Health, Bethesda, Maryland 20892, U.S.A..; Source Info: Jun96, Vol. 106 Issue 6, p1325; Subject Term: PSORIASIS; Subject Term: FREE radicals (Chemistry); Subject Term: FIBROBLASTS; Subject Term: ERYTHROCYTES; Subject Term: GLUTATHIONE; Subject Term: DERMATOLOGY; Author-Supplied Keyword: <em>erythrocytes</em>; Author-Supplied Keyword: <em>fibroblasts</em>; Author-Supplied Keyword: <em>free radicals</em>; Author-Supplied Keyword: <em>psoriasis</em>; Author-Supplied Keyword: <em>superoxide dismutases</em>; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12349055
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12349055&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107372537
T1  - The status of women's health research: where are African American women?
AU  - Pinn VW
Y1  - 1996/06//
N1  - Accession Number: 107372537. Language: English. Entry Date: 19960601. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8703519. 
KW  - Women's Health
KW  - Research
KW  - Blacks
KW  - Female
KW  - National Institutes of Health (U.S.)
KW  - Breast Neoplasms -- Ethnology
KW  - Breast Neoplasms -- Epidemiology
KW  - Mammography
KW  - Socioeconomic Factors
KW  - Clinical Trials
KW  - Research Subjects
KW  - Minority Groups
SP  - 8
EP  - 19
JO  - Journal of National Black Nurses Association
JF  - Journal of National Black Nurses Association
JA  - J NATL BLACK NURSES ASSOC
VL  - 8
IS  - 1
CY  - Silver Spring, Maryland
PB  - National Black Nurses' Association
SN  - 0885-6028
AD  - Office of Research on Women's Health, National Institutes of Health
U2  - PMID: 9128542.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107372537&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Svikis, Dace S.
AU  - Brooner, Robert K.
AU  - Rutigliano, Peter
AU  - Gazaway, Prestion
AU  - Fagan, Peter
AU  - Gupman, Anne
T1  - Psychosexual Functioning in Opioid-Dependent Women.
JO  - Journal of Sex Research
JF  - Journal of Sex Research
Y1  - 1996/06//
VL  - 33
IS  - 2
M3  - Article
SP  - 103
EP  - 111
PB  - Routledge
SN  - 00224499
AB  - This article presents a study on the psychosexual functioning in opioid-dependent women. The opioid-dependent group of 63 was drawn from a convenience sample of female patients enrolled in a hospital-based, publicly funded outpatient methadone-substitution therapy program between October 1989 and September 1991. These 63 patients comprised 58% of all new female admissions during the study period. Failure to collect data on all women was primarily related to lack of staff time rather than a systematic selection bias. Comparison, participants were recruited from 86 women awaiting a scheduled routine gynecological appointment at the same medical center between December 1990 and September 1991. Gynecological patients were selected for the comparison group because they comprised a clinical group that was the same sex, came from the same area and were approximately the same age as participants in the drug group. Gynecological patients attended the clinic for a number of reasons, predominantly routine annual physical examination or evaluation of a gynecological problem such as irregular or heavy menses, ovarian cysts.
KW  - OPIOID abuse
KW  - WOMEN patients
KW  - THERAPEUTICS
KW  - GYNECOLOGY
KW  - MEDICAL centers
KW  - HEALTH facilities
N1  - Accession Number: 9607254537; Svikis, Dace S. 1 Brooner, Robert K. 1 Rutigliano, Peter 1 Gazaway, Prestion 2 Fagan, Peter 1 Gupman, Anne 3; Affiliation:  1: Department of Psychiatry and Rehavioral Sciences, The Johns Hopkins University School of Medicine, Boltimore, MD.  2: Department of Obstetrics and Gynecology, John Hopkins University School of Medicine, Baltimore, MD  3: National Institute on Drug Abuse, Addiction Research Center, Boltimore, MD.; Source Info: Jun1996, Vol. 33 Issue 2, p103; Subject Term: OPIOID abuse; Subject Term: WOMEN patients; Subject Term: THERAPEUTICS; Subject Term: GYNECOLOGY; Subject Term: MEDICAL centers; Subject Term: HEALTH facilities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 6750
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107379294
T1  - Risk factors related to age-associated hearing loss in the speech frequencies.
AU  - Brant LJ
AU  - Gordon-Salant S
AU  - Pearson JD
AU  - Klein LL
AU  - Morrell CH
AU  - Metter EJ
AU  - Fozard JL
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107379294. Language: English. Entry Date: 19960801. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts; tracings. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9114646. 
KW  - Presbycusis
KW  - Risk Factors
KW  - Prospective Studies
KW  - Survival Analysis
KW  - Regression
KW  - Analysis of Variance
KW  - Descriptive Statistics
KW  - Confidence Intervals
KW  - Hypertension
KW  - Smoking
KW  - Alcohol Drinking
KW  - Aging
KW  - Speech Perception
KW  - Audiometry, Pure-Tone
KW  - Air Conduction
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 152
EP  - 160
JO  - Journal of the American Academy of Audiology
JF  - Journal of the American Academy of Audiology
JA  - J AM ACAD AUDIOL
VL  - 7
IS  - 3
CY  - Reston, Virginia
PB  - American Academy of Audiology
SN  - 1050-0545
AD  - Gerontology Research Center, National Institute on Aging, 4940 Eastern Ave, Baltimore, MD 21224
U2  - PMID: 8780987.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107379294&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Follmann, Dean
T1  - A Simple Multivariate Test for One-Sided Alternatives.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1996/06//
VL  - 91
IS  - 434
M3  - Article
SP  - 854
EP  - 861
SN  - 01621459
AB  - This article presents information on the simple test for multivariate normal data that has good power for alternatives where the mean vector tends to be positive. Testing whether the mean of a multivariate normal distribution tends to be positive is of interest in several applied settings. For example, in a two-armed clinical trial, the treatment might be expected to improve several end-points, relative to control. In a dose-response experiment, response might monotonically increase with dose, so that the vector of successive differences of the mean response would be expected to be positive. Normally, a test for a "one-sided" alternative has been translated to mean a test that has good power for mean vectors that lie in the positive orthant. Researchers derived likelihood ratio tests for this setting under the assumptions of a known and an unknown covariance matrix. Unfortunately, their tests are difficult to implement in practice due to the complicated null distribution of the test statistic. Researchers suggested an approximation to the likelihood ratio test that is somewhat simpler but still difficult to evaluate-especially if the dimension of the multivariate normal distribution is high, or if the result needs to be invariant under permutation of the indices of the mean vector.
KW  - MULTIVARIATE analysis
KW  - ANALYSIS of variance
KW  - DATA analysis
KW  - MATHEMATICAL models
KW  - GAUSSIAN distribution
KW  - DISTRIBUTION (Probability theory)
KW  - Clinical trial
KW  - Hypothesis test
KW  - Multiple endpoints
KW  - Order restrictions
N1  - Accession Number: 9606250350; Follmann, Dean 1; Affiliations: 1: Mathematical Statistician, Office of Biostatistics Research, National Heart Lung and Blood Institute, Bethesda, MD 20892; Issue Info: Jun96, Vol. 91 Issue 434, p854; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: DATA analysis; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: GAUSSIAN distribution; Thesaurus Term: DISTRIBUTION (Probability theory); Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Hypothesis test; Author-Supplied Keyword: Multiple endpoints; Author-Supplied Keyword: Order restrictions; Number of Pages: 8p; Illustrations: 2 Charts, 8 Graphs; Document Type: Article; Full Text Word Count: 6406
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107312461
T1  - Beta-carotene increases lung cancer incidence in cigarette smokers.
AU  - De Luca LM
AU  - Ross SA
Y1  - 1996/06//
N1  - Accession Number: 107312461. Language: English. Entry Date: 19970201. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405. 
KW  - Beta Carotene -- Adverse Effects
KW  - Lung Neoplasms -- Prevention and Control
KW  - Smoking -- Complications
KW  - Beta Carotene -- Therapeutic Use
SP  - 178
EP  - 180
JO  - Nutrition Reviews
JF  - Nutrition Reviews
JA  - NUTR REV
VL  - 54
IS  - 6
PB  - Oxford University Press / USA
SN  - 0029-6643
AD  - Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Bldg 37 Rm 3A-17, National Cancer Institute, Bethesda, MD 20892-4255
U2  - PMID: 8810825.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107312461&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107379059
T1  - Physical exercise as an oncology nursing intervention to enhance quality of life.
AU  - Smith SL
Y1  - 1996/06//1996 Jun
N1  - Accession Number: 107379059. Language: English. Entry Date: 19960801. Revision Date: 20150819. Publication Type: Journal Article; forms; review. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Quality of Life
KW  - Oncologic Nursing
KW  - Exercise
KW  - Cancer Patients -- Psychosocial Factors
KW  - Patient History Taking
KW  - Nursing Assessment
KW  - Research
SP  - 771
EP  - 778
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 23
IS  - 5
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - Purpose/Objectives: To examine how physical exercise can enhance the quality of life (QOL) of people with cancer and to provide general guidelines for incorporating exercise into care plans for these patients. Data Sources: Published and nonpublished medical, nursing, rehabilitation, and physical exercise literature. Data Synthesis: Including physical exercise in the care plans of people with cancer can enhance their QOL. The development of an individualized exercise plan for patients with cancer involves screening, assessment, prescription, goal setting, evaluation, and communication. The success of wellness-oriented interventions, such as exercise, can be evaluated with patient diaries, monitoring, and a QOL measurement tool. Conclusions: Physical exercise can positively influence all dimensions of life. Nurses must use sound clinical judgment and creativity and collaborate with other healthcare disciplines when prescribing exercise. Established exercise protocols for people with cancer are limited, and further research is needed in this area. Implications for Nursing Practice: Oncology nurses must continue to expand the literature on guidelines and precautions for exercise in oncology populations. Nurses need to use their knowledge of oncology, QOL, and exercise to recommend and encourage the incorporation of physical exercise into the care plans of people with cancer.
SN  - 0190-535X
AD  - National Cancer Institute, Bethesda, MD
U2  - PMID: 8792347.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107379059&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-38426-001
AN  - 2015-38426-001
AU  - Bowen, David C.
AU  - Sugiyama, Janice
AU  - Ferns, Michael
AU  - Hall, Zach W.
T1  - Neural agrin activates a high-affinity receptor in C2 muscle cells that is unresponsive to muscle agrin.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/06//
VL  - 16
IS  - 12
SP  - 3791
EP  - 3797
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Hall, Zach W., National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38426-001. PMID: 8656273 Partial author list: First Author & Affiliation: Bowen, David C.; Regeneron Pharmaceuticals, Tarrytown, NY, US. Release Date: 20160926. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Acetylcholine; Cholinergic Receptors; Membranes; Phosphorylation. Minor Descriptor: Cluster Analysis; Muscles. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 7. Issue Publication Date: Jun, 1996. Publication History: Accepted Date: Mar 25, 1996; Revised Date: Mar 18, 1996; First Submitted Date: Jan 10, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - During synaptogenesis, agrin, released by motor nerves, causes the clustering of acetylcholine receptors (AChRs) in the skeletal muscle membrane. Although muscle α-dystroglycan has been postulated to be the receptor for the activity of agrin, previous experiments have revealed a discrepancy between the biological activity of soluble fragments of two isoforms of agrin produced by nerves and muscles, respectively, and their ability to bind α-dystroglycan. We have determined the specificity of the signaling receptor by investigating whether muscle agrin can block the activity of neural agrin on intact C2 myotubes. We find that a large excess of muscle agrin failed to inhibit either the number of AChR clusters or the phosphorylation of the AChR induced by picomolar concentrations of neural agrin. These results indicate that neural, but not muscle, agrin interacts with the signaling receptor. Muscle agrin did block the binding of neural agrin to isolated α-dystroglycan, however, suggesting either that α-dystroglycan is not the signaling receptor or that its properties in the membrane are altered. Direct assay of the binding of muscle or neural agrin to intact myotubes revealed only low-affinity binding. We conclude that the signaling receptor for agrin is a high-affinity receptor that is highly specific for the neural form. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - acetylcholine receptor
KW  - agrin
KW  - dystroglycan
KW  - muscle
KW  - receptor
KW  - synaptogenesis
KW  - 1996
KW  - Acetylcholine
KW  - Cholinergic Receptors
KW  - Membranes
KW  - Phosphorylation
KW  - Cluster Analysis
KW  - Muscles
KW  - 1996
U1  - Sponsor: National Institutes of Health, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105854894
T1  - Factors associated with surgical and radiation therapy for early stage breast cancer in older women.
AU  - Ballard-Barbash R
AU  - Potosky AL
AU  - Harlan LC
AU  - Nayfield SG
AU  - Kessler LG
Y1  - 1996/06/05/
N1  - Accession Number: 105854894. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Therapy
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and Over
KW  - Combined Modality Therapy
KW  - Female
KW  - Neoplasm Staging
SP  - 716
EP  - 726
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 11
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7344, USA.
U2  - PMID: 8637025.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105854894&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854902
T1  - Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease.
AU  - Rybak SM
AU  - Pearson JW
AU  - Fogler WE
AU  - Volker K
AU  - Spence SE
AU  - Newton DL
AU  - Mikulski SM
AU  - Ardelt W
AU  - Riggs CW
AU  - Kung HF
AU  - Longo DL
AU  - Rybak, S M
AU  - Pearson, J W
AU  - Fogler, W E
AU  - Volker, K
AU  - Spence, S E
AU  - Newton, D L
AU  - Mikulski, S M
AU  - Ardelt, W
AU  - Riggs, C W
Y1  - 1996/06/05/
N1  - Accession Number: 105854902. Language: English. Entry Date: 20080314. Revision Date: 20161127. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antineoplastic Agents -- Pharmacodynamics
KW  - Antineoplastic Agents, Combined -- Pharmacodynamics
KW  - Esterases -- Pharmacodynamics
KW  - Proteins -- Pharmacodynamics
KW  - Vincristine -- Pharmacodynamics
KW  - Animals
KW  - Cells
KW  - Colonic Neoplasms -- Drug Therapy
KW  - Drug Resistance
KW  - Female
KW  - Mice
KW  - Vincristine -- Pharmacokinetics
KW  - Xenografts
SP  - 747
EP  - 753
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 11
PB  - Oxford University Press / USA
AB  - Background: Onconase, a protein isolated from oocytes and early embryos of the frog Rana pipiens, shares extensive homology with bovine pancreatic ribonuclease (RNase A) and possesses similar enzyme activity. Onconase is cytotoxic toward cancer cells in vitro and exhibits antitumor activity in animal models. In addition, Onconase has been shown to enhance the cytotoxic activity of some chemotherapeutic agents in vitro.Purpose: We studied interactions between the cytotoxic effects of Onconase and the chemotherapeutic agent vincristine (VCR) in the treatment of drug-sensitive and multidrug-resistant human colon carcinoma cells in vitro and in mice.Methods: Transplantable human colon carcinoma cells (HT-29par cells) were infected with a retrovirus containing human mdr1 (also known as MDR1 and PGY1) complementary DNA (encoding P-glycoprotein [P-gp]), and clones that were cross-resistant to colchicine, doxorubicin, and vinblastine were selected (HT-29mdr1 cells). Drug-resistant HT-29mdr1 cells and drug-sensitive HT-29par parental cells were treated with Onconase and/or VCR in vitro at varying concentrations to measure the effects on protein synthesis and cell viability. The impact of Onconase on VCR accumulation in both types of cells was determined in the presence or absence of MRK-16, an anti-P-gp monoclonal antibody capable of reversing the multidrug-resistant phenotype. The antitumor effects of Onconase and/or VCR treatment were assessed in nude mice bearing established HT-29par or HT-29mdr1 intraperitoneal tumors. IC50 values (drug concentrations resulting in 50% inhibition of protein synthesis or cell viability) for Onconase and VCR were determined from semilogarithmic dose-response curves; interactions between the cytotoxic effects of these two agents were evaluated using data from protein synthesis inhibition experiments and a two-way analysis of variance. Survival distributions from in vivo experiments were compared using Cox proportional hazards models.Results: The combination of Onconase and VCR yielded enhanced cytotoxicity in vitro that was independent of P-gp expression. Evaluation of the effects of these two compounds on protein synthesis over a wide range of drug concentrations indicated possible synergistic interactions (i.e., greater than additive effects) in both drug-resistant and drug-sensitive cells. The enhancement of VCR cytotoxicity was dependent on Onconase enzyme activity and was not associated with increased intracellular levels of VCR. Simultaneous treatment of mice bearing HT-29par tumors with Onconase and VCR did not extend their median survival time (MST) significantly (MST with VCR = 66 days; MST with VCR plus Onconase = 69 days; two-tailed P = .57); however, the MST of mice with HT-29mdr1 tumors was extended significantly by this treatment (MST with VCR = 44 days; MST with VCR plus Onconase = 66 days; two-tailed P<.001).Conclusion: Combined administration of Onconase and VCR yields enhanced cytotoxicity in vitro and in vivo against human colon carcinoma cells that overexpress the mdr1 gene.
SN  - 0027-8874
AD  - Laboratory of Biochemical Physiology, Biological Response Modifiers Program, National Cancer Institute-Frederick Center Research and Development Center, Frederick, MD 21702-1201, USA
U2  - PMID: 8637029.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105854899
T1  - Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status.
AU  - Potischman N
AU  - Swanson CA
AU  - Siiteri P
AU  - Hoover RN
Y1  - 1996/06/05/
N1  - Accession Number: 105854899. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Body Mass Index
KW  - Breast Neoplasms -- Etiology
KW  - Estradiol -- Blood
KW  - Menopause
KW  - Female
KW  - Middle Age
SP  - 756
EP  - 758
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 11
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 8637031.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Champoux, Maribeth
T1  - On the Mommy Track.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1996/07//
VL  - 39
IS  - 3
M3  - Book Review
SP  - 195
EP  - 200
SN  - 02752565
AB  - Reviews the book "Motherhood in Human and Nonhuman Primates: Biosocial Determinants," edited by C. R. Pryce, R. D. Martin and D. Skuse.
KW  - PRIMATES
KW  - PRYCE, C. R.
KW  - MARTIN, R. D.
KW  - SKUSE, D.
KW  - MOTHERHOOD in Human & Nonhuman Primates (Book)
N1  - Accession Number: 12320954; Champoux, Maribeth 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Maryland; Source Info: 1996, Vol. 39 Issue 3, p195; Subject Term: PRIMATES; Reviews & Products: MOTHERHOOD in Human & Nonhuman Primates (Book); People: PRYCE, C. R.; People: MARTIN, R. D.; People: SKUSE, D.; Number of Pages: 6p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sorensen, Glorian
AU  - Thompson, Beti
AU  - Glanz, Karen
AU  - Ziding Feng
AU  - Kinne, Susan
AU  - DiClemente, Carlo
AU  - Emmons, Karen
AU  - Heimendinger, Jerianne
AU  - Probart, Claudia
AU  - Lichtenstein, Edward
T1  - Work Site-Based Cancer Prevention: Primary Results from the Working Well Trial.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/07//
VL  - 86
IS  - 7
M3  - Article
SP  - 939
EP  - 939
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This paper presents the behavioral results of the Working Well Trial, the largest US work site cancer prevention and control trial to date. Methods. The Working Well Trial used a randomized, matched-pair evaluation design, with the work site as the unit of assignment and analysis. The study was conducted in 111 work sites (n = 28 000 workers). The effects of the intervention were evaluated by comparing changes in intervention and control work sites, as measured in cross-sectional surveys at baseline and follow-up. The 2-year intervention targeted both individuals and the work-site environment. Results. There occurred a net reduction in the percentage of energy obtained from fat consumption of 0.37 percentage points (P = .033), a net increase in fiber densities of 0.13 g/1000 kcal (P = .056), and an average increase in fruit and vegetable intake of 0.18 servings per day (P = .0001). Changes in tobacco use were in the desired direction but were not significant. Conclusions. Significant but small differences were observed for nutrition. Positive trends, but no significant results, were observed in trial-wide smoking outcomes. The observed net differences were small owing to the substantial secular changes in target behaviors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER prevention
KW  - INDUSTRIAL hygiene
KW  - WORK environment
KW  - TOBACCO use
KW  - SMOKING
KW  - UNITED States
N1  - Accession Number: 9607260463; Sorensen, Glorian 1,2 Thompson, Beti 3 Glanz, Karen 4 Ziding Feng 3 Kinne, Susan 3 DiClemente, Carlo 5 Emmons, Karen 6 Heimendinger, Jerianne 7 Probart, Claudia 8 Lichtenstein, Edward 9; Affiliation:  1: Dana-Farber Cancer Institute, Boston  2: Harvard School of Public Health, Boston  3: Fred Hutchinson Cancer Research Center, Seattle, Wash.  4: Cancer Research Center of Hawaii, Honolulu  5: University of Houston, Tex.  6: Brown University, Miriam Hospital, Providence, RI  7: National Cancer Institute, Rockville, Md.  8: Nutrition Department, Penn State University, University Park  9: Oregon Research Institute, Eugene; Source Info: Jul96, Vol. 86 Issue 7, p939; Subject Term: CANCER prevention; Subject Term: INDUSTRIAL hygiene; Subject Term: WORK environment; Subject Term: TOBACCO use; Subject Term: SMOKING; Subject Term: UNITED States; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 7697
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kawachi, Ichiro
AU  - Troisi, Rebecca J.
AU  - Rotnitzky, Andrea G.
AU  - Coakley, Eugenie H.
AU  - Colditz, Graham A.
T1  - Can Physical Activity Minimize Weight Gain in Women after Smoking Cessation?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/07//
VL  - 86
IS  - 7
M3  - Article
SP  - 999
EP  - 999
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The purpose of this study was to examine prospectively whether exercise can modify weight gain after smoking cessation in women. Methods. Data were analyzed from a 2-year follow-up period (1986-1988) in the Nurses' Health Study, an ongoing cohort of 121 700 US women aged 40 to 75 in 1986. Results. The average weight gain over 2 years was 3.0 kg in the 1474 women who stopped smoking, and 0.6 kg among the 7832 women who continued smoking. Among women smoking 1 to 24 cigarettes per day, those who quit without changing their levels of exercise gained an average of 2.3 kg more (95% confidence interval [CI] = 1.9, 2.6) than women who continued smoking. Women who quit and increased exercise by between 8 to 16 MET-hours (the work metabolic rate divided by the resting metabolic rate) per week gained 1.8 kg (95% CI = 1.0, 2.5), and the excess weight gain was only 1.3 kg (95% CI = 0.7, 1.9) in women who increased exercise by more than 16 MET-hours per week. Conclusions. Smoking cessation is associated with a net excess weight gain of about 2.4 kg in middle-aged women. However, this weight gain is minimized if smoking cessation is accompanied by a moderate increase in the level of physical activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXERCISE
KW  - WOMEN -- Health
KW  - WEIGHT gain
KW  - BODY weight
KW  - SMOKING
KW  - UNITED States
N1  - Accession Number: 9607260472; Kawachi, Ichiro 1,2 Troisi, Rebecca J. 3 Rotnitzky, Andrea G. 4 Coakley, Eugenie H. 4 Colditz, Graham A. 5; Affiliation:  1: Channing Laboratory and the Department of Health and Social Behavior, Harvard University  2: Brigham and Women's Hospital, Boston, Mass.  3: Channing Laboratory, Harvard University, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Md.  4: Department of Biostatistics, Harvard University  5: Department of Epidemiology, Harvard University; Source Info: Jul96, Vol. 86 Issue 7, p999; Subject Term: EXERCISE; Subject Term: WOMEN -- Health; Subject Term: WEIGHT gain; Subject Term: BODY weight; Subject Term: SMOKING; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article; Full Text Word Count: 5744
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moss, Nancy
T1  - The Social Organization of Sexuality: Sexual Practices in the United States/Sexual Attitudes and Lifestyles (Book).
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/07//
VL  - 86
IS  - 7
M3  - Book Review
SP  - 1037
EP  - 1039
PB  - American Public Health Association
SN  - 00900036
AB  - The article reviews two books related to sexual attitudes and behaviors, including "The Social Organization of Sexuality: Sexual Practices in the United States," by Edward O. Laumann, John H. Gagnon, Robert T. Michael and Stuart Michaels and "Sexual Attitudes and Lifestyles," by Anne M. Johnson, Jane Wadsworth, Kaye Wellings and Julia Field.
KW  - NONFICTION
KW  - LAUMANN, Edward O.
KW  - GAGNON, John, 1931-2016
KW  - MICHAEL, Robert T.
KW  - MICHAELS, Stuart
KW  - JOHNSON, Anne M.
KW  - WADSWORTH, Jane
KW  - WELLINGS, Kaye
KW  - FIELD, Julia
KW  - SOCIAL Organization of Sexuality: Sexual Practices in the United States, The (Book)
KW  - SEXUAL Attitudes & Lifestyles (Book)
N1  - Accession Number: 9607260484; Moss, Nancy 1; Affiliation:  1: Behavioral and Social Research Program National Institute on Aging, Bethesda; Source Info: Jul96, Vol. 86 Issue 7, p1037; Subject Term: NONFICTION; Reviews & Products: SOCIAL Organization of Sexuality: Sexual Practices in the United States, The (Book); Reviews & Products: SEXUAL Attitudes & Lifestyles (Book); People: LAUMANN, Edward O.; People: GAGNON, John, 1931-2016; People: MICHAEL, Robert T.; People: MICHAELS, Stuart; People: JOHNSON, Anne M.; People: WADSWORTH, Jane; People: WELLINGS, Kaye; People: FIELD, Julia; Number of Pages: 3p; Document Type: Book Review; Full Text Word Count: 2240
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cain, Virginia S.
T1  - Sexual Behavior and AIDS (Book).
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/07//
VL  - 86
IS  - 7
M3  - Book Review
SP  - 1039
EP  - 1040
PB  - American Public Health Association
SN  - 00900036
AB  - The article reviews the book "Sexual Behavior and AIDS," by Alfred Spira and Nathalie Bajos.
KW  - AIDS (Disease)
KW  - NONFICTION
KW  - SPIRA, Alfred
KW  - BAJOS, Nathalie
KW  - SEXUAL Behavior & AIDS (Book)
N1  - Accession Number: 9607260485; Cain, Virginia S. 1; Affiliation:  1: Office of Behavioral and Social Sciences Research National institutes of Health, Bethesda; Source Info: Jul96, Vol. 86 Issue 7, p1039; Subject Term: AIDS (Disease); Subject Term: NONFICTION; Reviews & Products: SEXUAL Behavior & AIDS (Book); People: SPIRA, Alfred; People: BAJOS, Nathalie; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 1550
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costa, Paul T.
T1  - Work and Personality: Use of the NEO-PI-R in Industrial/Organisational Psychology.
JO  - Applied Psychology: An International Review
JF  - Applied Psychology: An International Review
Y1  - 1996/07//
VL  - 45
IS  - 3
M3  - Article
SP  - 225
EP  - 241
PB  - Wiley-Blackwell
SN  - 0269994X
N1  - Accession Number: 62727184; Costa, Paul T. 1; Affiliation:  1: National Institute on Aging, USA; Source Info: Jul1996, Vol. 45 Issue 3, p225; Number of Pages: 17p; Document Type: Article
L3  - 10.1111/j.1464-0597.1996.tb00766.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107927680
T1  - Cost-Effectiveness of Detecting and Treating Diabetic Retinopathy.
AU  - Eastman, Richard
Y1  - 1996/07//
N1  - Accession Number: 107927680. Language: English. Entry Date: 20140108. Revision Date: 20150819. Publication Type: Journal Article; research. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8913432. 
KW  - Diabetic Retinopathy -- Therapy
KW  - Diabetic Retinopathy -- Economics
KW  - Cost Benefit Analysis
KW  - Diabetes Mellitus -- Complications
KW  - Diabetic Retinopathy -- Physiopathology
KW  - Blindness
KW  - Medical Organizations
KW  - Human
KW  - Data Analysis
SP  - 182
EP  - 183
JO  - Diabetes Spectrum
JF  - Diabetes Spectrum
JA  - DIABETES SPECTRUM
VL  - 9
IS  - 3
CY  - Alexandria, Virginia
PB  - American Diabetes Association
SN  - 1040-9165
AD  - Director, Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, in Bethesda, Md.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Weinberg, Irving
AU  - Majewski, Stan
AU  - Weisenberger, Andrew
AU  - Markowitz, Allen
AU  - Aloj, Luigi
AU  - Majewski, Lukasz
AU  - Danforth, David
AU  - Mulshine, James
AU  - Cowan, Kenneth
AU  - Zujewski, JoAnne
AU  - Chow, Catherine
AU  - Jones, Elizabeth
AU  - Chang, Victoria
AU  - Berg, Wendie
AU  - Frank, Joseph
T1  - Preliminary results for positron emission mammography: real-time functional breast imaging in a conventional mammography gantry.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1996/07//
VL  - 23
IS  - 7
M3  - Article
SP  - 804
EP  - 806
SN  - 03406997
N1  - Accession Number: 71147078; Weinberg, Irving 1 Majewski, Stan 2 Weisenberger, Andrew 2 Markowitz, Allen 1 Aloj, Luigi 1 Majewski, Lukasz 1 Danforth, David 1 Mulshine, James 1 Cowan, Kenneth 1 Zujewski, JoAnne 1 Chow, Catherine 1 Jones, Elizabeth 1 Chang, Victoria 1 Berg, Wendie 3 Frank, Joseph 1; Affiliation:  1: National Institutes of Health, Bethesda USA  2: Continuous Electron Beam Accelerator Facility, Newport News USA  3: Department of Radiology, University of Maryland, Baltimore USA; Source Info: Jul1996, Vol. 23 Issue 7, p804; Number of Pages: 3p; Document Type: Article
L3  - 10.1007/BF00843710
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - Family, Justice, and Delinquency (Book).
JO  - Family Relations
JF  - Family Relations
Y1  - 1996/07//
VL  - 45
IS  - 3
M3  - Book Review
SP  - 355
EP  - 355
SN  - 01976664
AB  - Reviews the book "Family, Justice, and Delinquency," by Brenda Geiger and Michael Fischer.
KW  - CRIME
KW  - NONFICTION
KW  - GEIGER, Brenda
KW  - FISCHER, Michael
KW  - FAMILY, Justice & Delinquency (Book)
N1  - Accession Number: 9608220326; Lamb, Michael E. 1; Affiliation:  1: Section on Social and Emotional Development, National Institute of Child Health and Human Development.; Source Info: Jul96, Vol. 45 Issue 3, p355; Subject Term: CRIME; Subject Term: NONFICTION; Reviews & Products: FAMILY, Justice & Delinquency (Book); People: GEIGER, Brenda; People: FISCHER, Michael; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 359
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - RAO, GHANTA N.
T1  - New Diet (NTP-2000) for Rats in the National Toxicology Program Toxicity and Carcinogenicity Studies.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/07//
VL  - 32
IS  - 1
M3  - Article
SP  - 102
EP  - 108
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Composition of diet may influence growth, diseases, tumor rates, and responses to chemical treatment. Since 1980 the NIH–07 open formula nonpurified diet has been the selected diet for the National Toxicology Program (NTP) toxicity and carcinogenicity studies in rodents. Studies with nonpurified experimental diets with lower protein and higher fat and fiber than the NIH-07 diet indicated that the diet for Fischer–344 (F344) rats in long-term studies could be modified to decrease the severity of chronic diseases and to decrease/delay the development of spontaneous tumors. Based on the results of these studies a new open formula nonpurified diet designated as NTP-2000 was formulated to contain ∼14.5% protein, ∼8.5% fat, and ∼9.5% fiber. Corn, wheat, and wheat middlings contribute to about 60% of the ingredients; soybean meal, fish meal, and alfalfa meal are the additional sources of protein; purified cellulose, oat hulls, and alfalfa meal are the major sources of fiber; and soy oil and corn oil are the major sources of fat in the NTP–2000 diet. The Ca:P ratio and mineral and vitamin concentrations were reformulated based on AIN–93 and NRC–95 recommendations. The NIH-07 and the NTP–2000 diets were fed to groups of 6–week–old F344 rats for 13 weeks and evaluated for growth patterns, food and water consumptions, hematology and clinical chemistry parameters, and organ weights and pathological changes. Growth patterns and body weights were similar for both diets. Food consumptions were slightly higher and water consumptions were slightly lower for the groups fed NTP–2000 diet. There were no differences in hematological parameters between the groups fed the above diets. Serum levels of cholesterol, alkaline phosphatase, and 5′ nucleotidase were slightly higher in groups fed the NTP–2000 diet possibly due to higher fat content of this diet. However, the serum triglyceride levels were slightly lower in groups fed the NTP–2000 diet and it may be related to higher fiber content of the NTP–2000 diet. The liver and kidney weights of the groups fed NTP-2000 diet were significantly lower possibly due to lower protein content of this diet and lower protein consumption associated changes in Phase I and Phase II drug metabolizing enzyme systems. The adrenal weights were also lower in groups fed the new diet. The NTP–2000 diet prevented nephrocalcinosis and decreased the severity of nephropathy and cardiomyopathy, the common lesions of F344 rats in 13–week studies. These results indicate that the NTP–2000 diet is adequate for growth and main tenance of rats and appears to prevent or decrease the severity of diet-associated lesions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RESEARCH
KW  - Carcinogenicity
KW  - Toxicity testing
KW  - Food consumption
KW  - Rats as laboratory animals
KW  - Chronic diseases
N1  - Accession Number: 82425518; RAO, GHANTA N. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; Issue Info: 1996, Vol. 32 Issue 1, p102; Thesaurus Term: RESEARCH; Thesaurus Term: Carcinogenicity; Thesaurus Term: Toxicity testing; Thesaurus Term: Food consumption; Subject Term: Rats as laboratory animals; Subject Term: Chronic diseases; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Coe, J. E.
AU  - Prince, G. A.
T1  - Definition of cotton rat immunoglobulins: sigmodon species differ in expression of IgG isotypes and production of respiratory syncytial virus antibody.
JO  - Immunology
JF  - Immunology
Y1  - 1996/07//
VL  - 88
IS  - 3
M3  - Article
SP  - 323
EP  - 330
PB  - Wiley-Blackwell
SN  - 00192805
AB  - The cotton rat (Sigmodon species) is the preferred animal model for experiments with a number of human pathogens, especially the respiratory viruses. The cotton rat is classified in the family Cricetidae (with hamsters and gerbils) and is a distant cousin of the common laboratory rat (Rattus) classified in the family Muridae (with the common laboratory mouse, Mus). Antibody reagents that are specific for cotton rat immunoglobulins have not been described. To enhance the usefulness of this model, four immunoglobulins in Sigmodon serum were characterized (18G1, lgG2, IgA, IgM) and antisera specific for each immunoglobulin were made. Sera from three different species of Sigmodon were examined, S. hispidus (SH), S. arizoni (SA) and S. fulviventer (SF). Although IgA and IgM appeared similar in all three species, the IgG were expressed differently because normal serum levels of IgG2 were deficient in SH when compared with SA and SF and to other rodents. Similarly, IgG2 antibody response to purified protein antigen was deficient in SH although the IgG1 antibody response was superior to that in SF and SA. The three cotton rat species were infected with respiratory syncytial virus, and the kinetics of the antibody response was measured. Neutralizing antibody developed faster and to a higher titre in SH than in SA and SF. The enhanced immunoresponsiveness in SH may compensate for the IgG2 deficiency in SH and these changes appear to be relatively recent events in the evolution of this most populous species of Sigmodon. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNOGLOBULINS
KW  - COTTON rats
KW  - IMMUNOGLOBULIN G
KW  - IMMUNOGLOBULIN M
KW  - IMMUNOSUPPRESSION
KW  - IMMUNE response -- Regulation
N1  - Accession Number: 14052616; Coe, J. E. 1 Prince, G. A. 2; Affiliation:  1: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT  2: Virion Systems, Inc., Rockville, MD, USA; Source Info: Jul96, Vol. 88 Issue 3, p323; Subject Term: IMMUNOGLOBULINS; Subject Term: COTTON rats; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNE response -- Regulation; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Levin, A.
AU  - Brubaker, G.
AU  - Shao, J. S.
AU  - Kumby, D.
AU  - O'Brien, T. R.
AU  - Goedert, J. J.
AU  - Strauss, K. W.
AU  - Blattner, W. A.
AU  - Hannet, I.
T1  - Determination of T-lymphocyte subsets on site in rural Tanzania: results in HIV-1 infected and non-infected individuals.
JO  - International Journal of STD & AIDS
JF  - International Journal of STD & AIDS
Y1  - 1996/07//
VL  - 7
IS  - 4
M3  - journal article
SP  - 288
EP  - 291
PB  - Sage Publications, Ltd.
SN  - 09564624
AB  - With the FACSCount flow cytometer, counts of CD4, CD8 and CD3 lymphocytes and CD4/CD8 ratios were performed in a rural hospital in Tanzania. A total of 168 subjects (21 HIV-1 seropositive and 147 HIV-1 seronegative) were tested as part of a population-based serosurvey and AIDS education programme; 134 other subjects were hospitalized patients who had signs and symptoms suggestive of AIDS (69 HIV-1 seropositive and 65 HIV-seronegative). Mean values for the 147 HIV-1 seronegative subjects from the local population were 980 CD4 cells (95% CI 930, 1031), 598 CD8 cells (560, 635) and CD4/CD8 ratio 1.78 (1.68, 1.89). Seropositive subjects from the local population had significantly lower CD4 cell counts, higher CD8 counts and a lower CD4/CD8 ratio. CD4 cells were significantly lower and CD8 cells significantly higher in HIV-1 seropositive hospital patients compared to HIV-1 seronegative patients. However, 23 (35%) seronegative hospital patients had CD4 counts lower than 600. These results establish baseline values for the lymphocyte subsets in this population and indicate that this technique can be used in remote areas to monitor progress of HIV-infected individuals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of STD & AIDS is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease)
KW  - T cells
KW  - HIV infections
KW  - Flow cytometry
KW  - Symptoms
KW  - Tanzania
KW  - CD4 cells
KW  - CD8 cells
KW  - HIV-1
KW  - TANZANIA
N1  - Accession Number: 22201842; Levin, A. 1; Brubaker, G. 2; Shao, J. S. 2; Kumby, D. 3; O'Brien, T. R. 4; Goedert, J. J. 4; Strauss, K. W. 5; Blattner, W. A. 4; Hannet, I. 5; Affiliations: 1: RTI Unit, Department of Virology, The Medical College of St Bartholomew's Hospital, London, UK; 2: Kilimanjaro Christian Medical Centre, Moshi, Tanzania; 3: Shirati Hospital, Shirati, Tanzania,; 4: Viral Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA; 5: Becton Dickinson, Erembodegen, Belgium; Issue Info: Jul1996, Vol. 7 Issue 4, p288; Thesaurus Term: AIDS (Disease); Subject Term: T cells; Subject Term: HIV infections; Subject Term: Flow cytometry; Subject Term: Symptoms; Subject: Tanzania; Author-Supplied Keyword: CD4 cells; Author-Supplied Keyword: CD8 cells; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: TANZANIA; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: journal article
L3  - 10.1258/0956462961917825
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Yee, Ying Cheung
AU  - Kisslinger, Benjamin
AU  - Yu, Victor L.
AU  - Jin, Ding Jun
T1  - A mechanism of rifamycin inhibition and resistance in Pseudomonas aeruginosa.
JO  - Journal of Antimicrobial Chemotherapy (JAC)
JF  - Journal of Antimicrobial Chemotherapy (JAC)
Y1  - 1996/07//
VL  - 38
IS  - 1
M3  - Article
SP  - 133
EP  - 137
SN  - 03057453
N1  - Accession Number: 80109555; Yee, Ying Cheung 1; Kisslinger, Benjamin 2; Yu, Victor L. 1,3; Jin, Ding Jun 4; Affiliations: 1: University of Pittsburgh Graduate School of Public Health, Department of Infectious Diseases and Microbiology Pittsburgh, Pennsylvania 15261; 2: Carnegie Mellon University, Mellon Institute 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213; 3: University of Pittsburgh School of Medicine, Division of Infectious Diseases Pittsburgh, Pennsylvania 15213; 4: Laboratory of Molecular Biology National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892-4255, USA; Issue Info: 1996, Vol. 38 Issue 1, p133; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Johnson, J. David
AU  - Meyer, Marcy
AU  - Berkowitz, Judy
AU  - Ethington, Caroline
AU  - Miller, Vernon
AU  - Stengle, William
AU  - Steverson, Debra
T1  - The Role of a Conference in Integrating a Contractual Network of Health Services Organizations.
JO  - Journal of Business Communication
JF  - Journal of Business Communication
Y1  - 1996/07//
VL  - 33
IS  - 3
M3  - Article
SP  - 231
EP  - 256
PB  - Association for Business Communication
SN  - 00219436
AB  - The conference can be seen as a key strategic tool to be used in linking a diverse array of participants, through communicative processes, to achieve the level of integration required by new organizational forms, such as a contractual network. The present research models the necessary prior conditions for conference success, conference process variables, conference outcomes, and long-term consequences of effective integration for an organization that ultimately determine the effectiveness of a conference as an integrating mechanism. In general, the most important elements of the model in this empirical test were those associated with planning. Individuals get out of conferences what they put into them; old-timers who were active in the planning of the conference had very positive reactions. Thus, one way of enhancing conferences for all participants would be involving more people in their planning and execution. Conferences are, however, exceedingly expensive and only in special circumstances will their use as integrating mechanisms be justified. There are also circumstances where too much integration becomes a bad thing for an organization and not all conferences will be effective integrating mechanisms. Generally, organizations which could successfully utilize a conference will be faced with one or another of the following circumstances: a high level of differentiation with many functional subunits, a high need to maintain an organizational culture, or a highly dynamic environment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Business Communication is the property of Association for Business Communication and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Conferences & conventions
KW  - Communication in organizations
KW  - Social integration
KW  - Organizational structure
KW  - Communication in management
KW  - Communication
KW  - Questionnaires
KW  - Organization
KW  - Strategic planning
KW  - Empirical research
KW  - Chi-squared test
KW  - Variances
N1  - Accession Number: 790922; Johnson, J. David 1; Meyer, Marcy 1; Berkowitz, Judy 1; Ethington, Caroline 1; Miller, Vernon 1; Stengle, William 2; Steverson, Debra 3; Affiliations: 1: Michigan State University; 2: Michigan Cancer Foundation; 3: National Cancer Institute; Issue Info: Jul96, Vol. 33 Issue 3, p231; Thesaurus Term: Conferences & conventions; Thesaurus Term: Communication in organizations; Thesaurus Term: Social integration; Thesaurus Term: Organizational structure; Thesaurus Term: Communication in management; Thesaurus Term: Communication; Thesaurus Term: Questionnaires; Subject Term: Organization; Subject Term: Strategic planning; Subject Term: Empirical research; Subject Term: Chi-squared test; Subject Term: Variances; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 26p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 107389261
T1  - Investigation therapies: vaccine therapy for patients with metastatic or locally advanced cervical cancer.
AU  - Bernstein S
AU  - Khleif SN
Y1  - 1996///1996 Summer
N1  - Accession Number: 107389261. Language: English. Entry Date: 19961101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 101206753. 
KW  - Cervix Neoplasms -- Drug Therapy
KW  - Viral Vaccines -- Therapeutic Use
KW  - Cervix Neoplasms -- Etiology
KW  - Papillomavirus Infections -- Complications
KW  - Clinical Trials
SP  - 16
EP  - 18
JO  - Journal of Gynecologic Oncology Nursing
JF  - Journal of Gynecologic Oncology Nursing
JA  - J GYNECOL ONCOL NURS
VL  - 6
IS  - 3
CY  - Pasadena, Texas
PB  - Society of Gynecologic Nurse Oncologists
SN  - 1536-9935
AD  - National Cancer Institute, Navy Medical Oncology Branch, National Naval Medical Center
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Bale, Sherri J.
AU  - Compton, John G.
AU  - Russell, Laura J.
AU  - DiGiovanna, John J.
T1  - Genetic Heterogeneity in Lamellar Ichthyosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/07//
VL  - 107
IS  - 1
M3  - Letter
SP  - 140
EP  - 140
SN  - 0022202X
AB  - Presents a letter to the editor about lamellar ichthyosis, published in the 1996 issue of the "The Journal of Investigative Dermatology."
KW  - LETTERS to the editor
KW  - ICHTHYOSIS
N1  - Accession Number: 12298430; Bale, Sherri J. 1 Compton, John G. 2 Russell, Laura J. 3 DiGiovanna, John J. 4; Affiliation:  1: Chief, Genetic Studies Section, LSB  2: Staff Scientist, Genetic Studies Section, LSB  3: Sr. Staff Fellow, Genetic Studies Section, LSB  4: Head, Dermatology Clinical Research Unit, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease National Institutes of Health, 6 Center Dr., MSC-2757, Bethesda, MD 20892-2757; Source Info: Jul96, Vol. 107 Issue 1, p140; Subject Term: LETTERS to the editor; Subject Term: ICHTHYOSIS; Number of Pages: 3/4p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12298430
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zeiger, Errol
T1  - The MINISCREEN assay.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1996/07//
VL  - 11
IS  - 4
M3  - Article
SP  - 415
EP  - 415
PB  - Oxford University Press / USA
SN  - 02678357
KW  - Biological assay
KW  - Carcinogens
KW  - Salmonella
KW  - Environmental toxicology
KW  - Letters to the editor
KW  - Ames test
N1  - Accession Number: 79237819; Zeiger, Errol 1; Affiliations: 1: Environmental Toxicology Program National Institute of Environmental Health Sciences PO Box 12233 Research Triangle Park NC 27709 USA; Issue Info: Jul1996, Vol. 11 Issue 4, p415; Thesaurus Term: Biological assay; Thesaurus Term: Carcinogens; Thesaurus Term: Salmonella; Thesaurus Term: Environmental toxicology; Subject Term: Letters to the editor; Subject Term: Ames test; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107352611
T1  - Occupational epidemiologic study design and application.
AU  - Blair A
AU  - Hayes RB
AU  - Stewart PA
AU  - Zahm SH
Y1  - 1996/07//1996 Jul-Sep
N1  - Accession Number: 107352611. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629. 
KW  - Occupational Health
KW  - Study Design
KW  - Epidemiological Research
KW  - Case Control Studies
KW  - Prospective Studies
KW  - Environmental Monitoring
KW  - Life Style
KW  - Occupational Diseases -- Epidemiology
KW  - Occupational Diseases -- Etiology
KW  - Reproducibility of Results
KW  - Risk Factors
SP  - 403
EP  - 419
JO  - Occupational Medicine: State of the Art Reviews
JF  - Occupational Medicine: State of the Art Reviews
JA  - OCCUP MED STATE ART REV
VL  - 11
IS  - 3
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The optimal study design to evaluate potential occupational hazards varies according to research objectives, disease, understanding of etiology, and location of the study populations. This chapter provides a description of the application of the most frequently used epidemiologic designs for occupational studies and focuses on issues especially important in hypothesis-testing investigations of chronic diseases.
SN  - 0885-114X
AD  - Occupatonal Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Room 418, Bethesda, MD 20892-7364
U2  - PMID: 8887376.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Brownley, Kimberly A.
AU  - Light, Kathleen C.
AU  - Anderson, Norman B.
T1  - Social support and hostility interact to influence clinic, work, and home blood pressure in Black and White men and women.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1996/07//
VL  - 33
IS  - 4
M3  - Article
SP  - 434
EP  - 445
SN  - 00485772
AB  - The effects of hostility and social support on clinic, work, and home systolic (SBP) and diastolic (DBP) blood pressures were evaluated in 129 healthy adults. High hostility was related to higher SBP and DBP in Whites; low hostility was related to higher SBP and DBP in Blacks. These relationships were significant for men at home and at work and for women at screening. The relationship between low hostility and higher BP in Blacks was largely due to Black men who reported low hostility plus high anger-in (suggesting suppressed hostility). In contrast, high hostile Black men with high tangible support tended to exhibit lower BP than all other Black men. In White women, high belonging support was related to lower BP, independent of hostility, and low tangible support plus high hostility was related to higher clinic BP. In high hostile subjects, regardless of ethnicity or gender, high appraisal support was related to lower overall BP. These data suggest that the adverse BP effects of hostility and the beneficial effects of social support interact in a complex manner, reflecting contextual, ethnic, and gender specificities. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOSTILITY (Psychology)
KW  - BLACKS
KW  - WHITES
KW  - SOCIAL networks
KW  - SOCIAL groups
KW  - AGGRESSION (Psychology)
KW  - BLOOD pressure
KW  - ambulatory blood pressure
KW  - anger
KW  - ethnicity.
KW  - gender
KW  - hostility
KW  - social support
N1  - Accession Number: 10968972; Brownley, Kimberly A. 1 Light, Kathleen C. 1 Anderson, Norman B. 2; Affiliation:  1: Departments of Psychology and Psychiatry, Univerity of North Carolina, Chapel Hill, USA  2: Office of Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, MD, USA; Source Info: Jul1996, Vol. 33 Issue 4, p434; Subject Term: HOSTILITY (Psychology); Subject Term: BLACKS; Subject Term: WHITES; Subject Term: SOCIAL networks; Subject Term: SOCIAL groups; Subject Term: AGGRESSION (Psychology); Subject Term: BLOOD pressure; Author-Supplied Keyword: ambulatory blood pressure; Author-Supplied Keyword: anger; Author-Supplied Keyword: ethnicity.; Author-Supplied Keyword: gender; Author-Supplied Keyword: hostility; Author-Supplied Keyword: social support; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 12p; Document Type: Article
L3  - 10.1111/1469-8986.ep10968972
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2015-38422-002
AN  - 2015-38422-002
AU  - Murphy, Diane D.
AU  - Segal, Menahem
T1  - Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/07//
VL  - 16
IS  - 13
SP  - 4059
EP  - 4068
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Segal, Menahem, Department of Neurobiology, Weizmann Institute, Rehovot, Israel, 76100
N1  - Accession Number: 2015-38422-002. PMID: 8753868 Partial author list: First Author & Affiliation: Murphy, Diane D.; Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dendrites; Estradiol; Hippocampus; Steroids. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Jul, 1996. Publication History: Accepted Date: Apr 2, 1996; Revised Date: Apr 2, 1996; First Submitted Date: Dec 8, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - [Correction Notice: An Erratum for this article was reported in Vol 16(16) of The Journal of Neuroscience (see record [rid]2015-38425-033[/rid]). In the original article, a mistake was discovered in the presentation of the error bars in Figures 2-6. The correct SEMs are as follows, from left to right: Fig. 2: 0.568, 0.92, 0.285, 0.443, 0.871. Fig. 3: 0.288, 0.524, 0.247, 0.25, 0.288, 0.375. Fig. 4: 0.422, 0.345, 0.436, 0.361, 0.394. Fig. 5: 0.372, 0.492, 0.408, 0.643, 0.341, 0.344, 0.139, 0.507. Fig. 6: 0.292, 0.463, 0.256, 0.188, 0.23, 0.457, 0.423, 0.426.] The effects of gonadal steroid hormones on dendritic spines were studied in hippocampal neurons that were dissociated and grown in culture for 2–3 weeks. Exposure to estradiol caused up to a twofold increase in dendritic spine density in these neurons. The effect of estradiol was stereospecific and blocked by the steroid antagonist tamoxifen. The estradiol-induced rise in spine density was blocked by the NMDA antagonist APV, but not by the AMPA/KA antagonist DNQX. The estradiol-induced rise in spine density was blocked by the serine/threonine kinase inhibitor H7, but not by the tyrosine kinase inhibitor genestein, and was partially mimicked by PMA, an activator of protein kinase C. Estradiol also caused an increase in the fluorescence intensity of synaptophysin-immunoreactive terminals, corresponding to presynaptic boutons. Finally, estradiol caused a rise in [Ca]i reactivity of the cultured neurons to topical application of glutamate. These studies are the first to examine receptor and second messenger regulation of dendritic spines, and they illustrate the viability of cultured neurons as a powerful test system to address issues related to the regulation of dendritic spine maturation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dendritic spines
KW  - estradiol
KW  - culture
KW  - hippocampal neurons
KW  - calcium
KW  - plasticity
KW  - 1996
KW  - Dendrites
KW  - Estradiol
KW  - Hippocampus
KW  - Steroids
KW  - Rats
KW  - 1996
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38422-012
AN  - 2015-38422-012
AU  - Svingos, Adena L.
AU  - Moriwaki, Akiyoshi
AU  - Wang, Jia Bei
AU  - Uhl, George R.
AU  - Pickel, Virginia M.
T1  - Ultrastructural immunocytochemical localization of μ-opioid receptors in rat nucleus accumbens: Extrasynaptic plasmalemmal distribution and association with Leu⁵- enkephalin.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/07//
VL  - 16
IS  - 13
SP  - 4162
EP  - 4173
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Svingos, Adena L., Department of Neurology and Neuroscience, Cornell University Medical College, 411 East 69th Street, New York, NY, US, 10021
N1  - Accession Number: 2015-38422-012. PMID: 8753878 Partial author list: First Author & Affiliation: Svingos, Adena L.; Division of Neurobiology, Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Svingos, Adena L. Major Descriptor: Enkephalins; Neural Receptors; Nucleus Accumbens; Opiates; Immunocytochemistry. Minor Descriptor: Dendrites; Immunoreactivity; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Jul, 1996. Publication History: Accepted Date: Apr 24, 1996; Revised Date: Apr 18, 1996; First Submitted Date: Oct 11, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - µ-Opioid receptors and their endogenous ligands, including Leu⁵-enkephalin (LE), are distributed abundantly in the nucleus accumbens (NAC), a region implicated in mechanisms of opiate reinforcement. We used immunoperoxidase and/or immunogold-silver methods to define ultrastructural sites for functions ascribed to µ-opioid receptors and potential sites for activation by LE in the NAC. An antipeptide antibody raised against an 18 amino acid sequence of the cloned µ-opioid receptor (MOR) C terminus showed that MOR-like immunoreactivity (MOR-LI) was localized predominantly to extrasynaptic sites along neuronal plasma membranes. The majority of neuronal profiles containing MOR-LI were dendrites and dendritic spines. The dendritic plasma membranes immunolabeled for MOR were near sites of synaptic input from LE-labeled terminals and other unlabeled terminals forming either inhibitory or excitatory type synapses. Unmyelinated axons and axon terminals were also intensely but less frequently immunoreactive for MOR. Observed sites for potential axonal associations with LE included coexistence of MOR and LE within the same terminal, as well as close appositions between differentially labeled axons. Astrocytic processes rarely contained detectable MOR-LI, but also were sometimes observed in apposition to LE-labeled terminals. We conclude that in the rat NAC, MOR is localized prominently to extrasynaptic neuronal and more rarely to glial plasma membranes that are readily accessible to released LE and possibly other opioid peptides and opiate drugs. The close affiliation of MOR with spines receiving excitatory synapses and dendrites receiving inhibitory synapses provides the first direct morphological evidence that MOR selectively modulates postsynaptic responses to cortical and other afferents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - μ-opioid receptor
KW  - reinforcement
KW  - striatum
KW  - enkephalin
KW  - morphine
KW  - opiates
KW  - 1996
KW  - Enkephalins
KW  - Neural Receptors
KW  - Nucleus Accumbens
KW  - Opiates
KW  - Immunocytochemistry
KW  - Dendrites
KW  - Immunoreactivity
KW  - Rats
KW  - 1996
U1  - Sponsor: Aaron Diamond Foundation. Other Details: Postdoctoral Fellowship. Recipients: Svingos, Adena L.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: DA04600. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, Intramural Research Group, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38423-012
AN  - 2015-38423-012
AU  - Bencsics, Craig
AU  - Wachtel, Stephen R.
AU  - Milstien, Sheldon
AU  - Hatakeyama, Kazuyuki
AU  - Becker, Jill B.
AU  - Kang, Un Jung
T1  - Double transduction with GTP cyclohydrolase i and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/07//
VL  - 16
IS  - 14
SP  - 4449
EP  - 4456
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Kang, Un Jung, Department of Neurology, University of Chicago, MC 2030, 5841 South Maryland Avenue, Chicago, IL, US, 60637
N1  - Accession Number: 2015-38423-012. PMID: 8699255 Partial author list: First Author & Affiliation: Bencsics, Craig; Department of Neurology, University of Chicago, Chicago, IL, US. Release Date: 20160929. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Kang, Un Jung. Major Descriptor: Catecholamines; Parkinson's Disease; Gene Therapy. Minor Descriptor: Neural Transplantation. Classification: Genetics (2510); Neurological Disorders & Brain Damage (3297). Population: Human (10); Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: Jul, 1996. Publication History: Accepted Date: Apr 17, 1996; Revised Date: Mar 26, 1996; First Submitted Date: Dec 13, 1995. Copyright Statement: Society for Neuroscience. 1996. 
AB  - Gene transfer of tyrosine hydroxylase (TH) in animal models of Parkinson’s disease (PD), using either genetically modified cells or recombinant virus vectors, has produced partial restoration of behavioral and biochemical deficits. The limited success of this approach may be related to the availability of the cofactor, tetrahydrobiopterin (BH₄), because neither the dopamine-depleted striatum nor the cells used for gene transfer possess a sufficient amount of BH₄ to support TH activity. To determine the role of BH₄ in gene therapy, fibroblast cells transduced with the gene for TH were additionally modified with the gene for GTP cyclohydrolase I, an enzyme critical for BH₄ synthesis. In contrast to cells transduced with only TH, doubly transduced fibroblasts spontaneously produced both BH₄ and 3,4-dihydroxy-L-phenylalanine. To examine further the importance of GTP cyclohydrolase I in gene therapy for PD, in vivo microdialysis was used to assess the biochemical changes in the dopamine-denervated striatum containing grafts of genetically modified fibroblasts. Only denervated striata grafted with fibroblasts possessing both TH and GTP cyclohydrolase I genes displayed biochemical restoration. However, no significant differences from controls were observed in apomorphine-induced rotation. This is partly attributable to a limited duration of gene expression in vivo. These differences between fibroblasts transduced with TH alone and those additionally modified with the GTP cyclohydrolase I gene indicate that BH₄ is critical for biochemical restoration in a rat model of PD and that GTP cyclohydrolase I is sufficient for production of BH₄. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - tetrahydrobiopterin
KW  - Parkinson’s disease
KW  - gene therapy
KW  - retrovirus vector
KW  - transplantation
KW  - catecholamine
KW  - 1996
KW  - Catecholamines
KW  - Parkinson's Disease
KW  - Gene Therapy
KW  - Neural Transplantation
KW  - 1996
U1  - Sponsor: Parkinson’s Disease Foundation. Grant: R29 NS32080. Other Details: Junior Faculty Award. Recipients: No recipient indicated
U1  - Sponsor: United Parkinson Foundation. Other Details: H.G. and Catharine Lieneman Memorial Fund. Recipients: No recipient indicated
U1  - Sponsor: National Parkinson Foundation. Recipients: No recipient indicated
U1  - Sponsor: Dystonia Medical Research Foundation. Recipients: No recipient indicated
U1  - Sponsor: Brain Research Foundation. Recipients: Kang, Un Jung
U1  - Sponsor: Sponsor name not included. Grant: T32 NS07113. Recipients: Bencsics, Craig
U1  - Sponsor: Sponsor name not included. Grant: T32 DA07255. Recipients: Wachtel, Stephen R.
U1  - Sponsor: Sponsor name not included. Grant: NS22157. Recipients: Becker, Jill B.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38423-012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38423-015
AN  - 2015-38423-015
AU  - Davenport, Roger W.
AU  - Thies, Edda
AU  - Nelson, Phillip G.
T1  - 'Cellular localization of guidance cues in the establishment of retinotectal topography': Correction.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/07//
VL  - 16
IS  - 14
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Davenport, Roger W., Laboratory of Developmental Neurobiology, National Institutes of Health, 49/5A32, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38423-015. Partial author list: First Author & Affiliation: Davenport, Roger W.; Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160929. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Neurons; Neuropsychology; Topography; Cellular Neuroscience. Classification: Neuropsychology & Neurology (2520). Issue Publication Date: Jul, 1996. 
AB  - Reports an error in 'Cellular localization of guidance cues in the establishment of retinotectal topography' by Roger W. Davenport, Edda Thies and Phillip G. Nelson (The Journal of Neuroscience, 1996[Mar], Vol 16[6], 2074-2085). In the original article, in Figure 2. The lower portion and scale bar of Figure 2, page 2077, inadvertently were missing. The scale bar for this figure (0.2 mm) should have appeared in print as 15.2 mm in length in the lower panel (E). (The following abstract of the original article appeared in record [rid]2015-38281-013[/rid]). Topographic projections of the nervous system are essential to numerous brain functions. They arise during development as a result of encounters between projecting growth cones and particular target cells. Cellular localization of guidance cues can indicate the sequential processes involved in establishment of such topography. The map formed by retinal ganglion cells on their target nuclei has served widely as a model system to investigate mechanisms underlying the highly precise and stereotypic connectivity of the nervous system. To investigate cellular localization of guidance cues in the developing retinotectal system, a three-compartment chamber was created to delimit areas where cultured embryonic chick retinal ganglion axons and tectal cells encounter one another and guidance behavior could be readily assessed. Whereas explants from nasal retinae extended fibers across their natural target population, fibers from temporal regions of retinae failed to invade areas of growing posterior tectal cells. This preservation of relevant guidance information on living cell populations enabled an evaluation of retinal ganglion cell growth cone behavior after encounter with individual tectal cells. Posterior tectal neurons appeared selectively repulsive for temporal retinal ganglion cell growth cones, causing growth cone collapse and retraction. On the contrary, neuroepithelial cells from all regions of the tectum attenuated retinal ganglion axon extension, without inducing sudden retraction. Nasal growth cones traversed or tracked more often along neuroepithelial cells from their natural target area, potentially indicating a second set of guidance cues possibly localized to posterior glia. Together, these differential interactions suggest that development of retinotectal topography critically depends on cell-specific cues, which are distributed selectively on particular populations of target cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - retinotectal
KW  - topographic projection
KW  - growth cone
KW  - neuronal development
KW  - filopodia
KW  - navigation
KW  - guidance
KW  - repulsion
KW  - retraction
KW  - 1996
KW  - Neurons
KW  - Neuropsychology
KW  - Topography
KW  - Cellular Neuroscience
KW  - 1996
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107337890
T1  - Postherpetic neuralgia -- pathogenesis, treatment, and prevention.
AU  - Kost RG
AU  - Straus SE
Y1  - 1996/07/04/
N1  - Accession Number: 107337890. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Herpes Zoster -- Complications
KW  - Neuralgia -- Therapy
KW  - Neuralgia -- Prevention and Control
KW  - Neuralgia -- Epidemiology
SP  - 32
EP  - 42
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 335
IS  - 1
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 11N228, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 8637540.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107271917
T1  - Global burden of the HIV pandemic.
AU  - Quinn TC
Y1  - 1996/07/13/
N1  - Accession Number: 107271917. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - HIV Infections -- Epidemiology
KW  - World Health
KW  - HIV Infections -- Transmission
KW  - Acquired Immunodeficiency Syndrome -- Mortality
KW  - Prevalence
KW  - Disease Outbreaks
KW  - HIV Infections -- Economics
SP  - 99
EP  - 106
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 348 North American Edition
IS  - 9020
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - National Institute of Allergy and Infectious Diseases; and Johns Hopkins University, 720 Rutland Ave, Ross 1159, Baltimore, Maryland 21205-2196
U2  - PMID: 8676726.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107283575
T1  - Advances in the management of AIDS-related cytomegalovirus retinitis.
AU  - Masur H
AU  - Whitcup SM
AU  - Cartwright C
AU  - Polis M
AU  - Nussenblatt R
Y1  - 1996/07/15/
N1  - Accession Number: 107283575. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; commentary; pictorial; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - AIDS-Related Opportunistic Infections -- Drug Therapy
KW  - Cytomegalovirus Infections -- Drug Therapy
KW  - Retinal Diseases -- Drug Therapy
KW  - Retinal Diseases -- Diagnosis
KW  - Cytomegalovirus Infections -- Diagnosis
KW  - AIDS-Related Opportunistic Infections -- Diagnosis
KW  - Diagnosis, Differential
KW  - Prognosis
KW  - Vision Screening
KW  - Antiviral Agents -- Therapeutic Use
KW  - Congresses and Conferences
SP  - 126
EP  - 136
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 125
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 0003-4819
AD  - Critical Care Medicine Department, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892
U2  - PMID: 8678367.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Vogel, Steven S.
AU  - Blank, Paul S.
AU  - Zimmerberg, Joshua
T1  - Poisson-distributed Active Fusion Complexes Underlie theControl of the Rate and Extent of Exocytosis by Calcium.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1996/07/15/
VL  - 134
IS  - 2
M3  - Article
SP  - 329
EP  - 338
SN  - 00219525
AB  - Focuses on the investigation of the consequences for havingmultiple fusion complexes on exocytotic granules and the principlefor interpreting the calcium dependence of calcium-triggeredexocytosis.  Distribution of the active fusion complexes as aPoisson process among the population of granules; Steps involved inexocytosis; Simplicity of cortical granule exocytosis in vitro.
KW  - EXOCYTOSIS
KW  - CYTOPLASMIC granules
KW  - CALCIUM
KW  - POISSON processes
N1  - Accession Number: 11238792; Vogel, Steven S. 1; Email Address: Steven_Vogel@nih.gov Blank, Paul S. 1 Zimmerberg, Joshua 1; Affiliation:  1: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892; Source Info: Jul96, Vol. 134 Issue 2, p329; Subject Term: EXOCYTOSIS; Subject Term: CYTOPLASMIC granules; Subject Term: CALCIUM; Subject Term: POISSON processes; Number of Pages: 103p; Illustrations: 1 Diagram, 7 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scidmore, Marci A.
AU  - Fischer, Elizabeth R.
AU  - Hackstadt, Ted
T1  - Sphingolipids and Glycoproteins Are Differentially Traffickedto the Chlamydia trachomatis Inclusion.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1996/07/15/
VL  - 134
IS  - 2
M3  - Article
SP  - 363
EP  - 374
SN  - 00219525
AB  - Focuses on the major disruption of a cellular exocytoticpathway and the similarities between glycolipid and glycoproteinexocytosis.  Analysis on the processing of several modelglycoproteins; Rate of exocytosis from the recycling endosomes tothe plasma membrane; Existence of the sorting of sphingolipid andglycoproteins in Chlamydia trachomatis.
KW  - GLYCOLIPIDS
KW  - GLYCOPROTEINS
KW  - EXOCYTOSIS
KW  - CELL membranes
KW  - SPHINGOLIPIDS
N1  - Accession Number: 11238795; Scidmore, Marci A. 1 Fischer, Elizabeth R. 2 Hackstadt, Ted 1; Email Address: ted_hackstadt@nih.gov; Affiliation:  1: Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, 59840  2: Microscopy Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, 59840; Source Info: Jul96, Vol. 134 Issue 2, p363; Subject Term: GLYCOLIPIDS; Subject Term: GLYCOPROTEINS; Subject Term: EXOCYTOSIS; Subject Term: CELL membranes; Subject Term: SPHINGOLIPIDS; Number of Pages: 12p; Illustrations: 8 Diagrams, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Liesi, Päivi
AU  - Wright, Jerry M.
T1  - Weaver Granule Neurons Are Rescued by Calcium ChannelAntagonists and Antibodies Against a Neurite Outgrowth Domain ofthe B2 Chain of Laminin.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1996/07/15/
VL  - 134
IS  - 2
M3  - Article
SP  - 477
EP  - 486
SN  - 00219525
AB  - Focuses on the impairment of migration of the cerebellargranular neurons and induction of neuronal death due to the weavermutation.  Demonstration of neurite outgrowth of the normal andweaver granule neurons on a laminin substratum; Quantification ofneuronal survival and outgrowth of long neurites in cultures of thenormal granule neurons; Evaluation on the neuronal migration of theweaver granule neurons.
KW  - NEURONS
KW  - MUTATION (Biology)
KW  - CYTOPLASMIC granules
KW  - CELL migration
N1  - Accession Number: 11238804; Liesi, Päivi 1; Email Address: liesi@helix.nih.gov Wright, Jerry M. 1; Affiliation:  1: Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852; Source Info: Jul96, Vol. 134 Issue 2, p477; Subject Term: NEURONS; Subject Term: MUTATION (Biology); Subject Term: CYTOPLASMIC granules; Subject Term: CELL migration; Number of Pages: 10p; Illustrations: 3 Diagrams, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105854927
T1  - UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
AU  - Wang Q
AU  - Fan S
AU  - Eastman A
AU  - Worland PJ
AU  - Sausville EA
AU  - O'Connor PM
Y1  - 1996/07/17/
N1  - Accession Number: 105854927. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Alkaloids -- Pharmacodynamics
KW  - Antineoplastic Agents -- Pharmacodynamics
KW  - Cell Physiology -- Drug Effects
KW  - Oncogenes
KW  - Alkaloids -- Analogs and Derivatives
KW  - Cell Physiology -- Radiation Effects
KW  - Cell Physiology
KW  - Cells
KW  - Cisplatin -- Pharmacodynamics
KW  - Colonic Neoplasms -- Drug Therapy
KW  - Cytogenetic Analysis
KW  - Drug Synergism
KW  - Flow Cytometry
KW  - Gamma Rays
KW  - Immunoblotting
KW  - Lymphoma, B-Cell -- Drug Therapy
KW  - Mutation
KW  - Precipitin Tests
KW  - Proteins -- Drug Effects
KW  - Proteins -- Radiation Effects
KW  - Radiation Dosage
SP  - 956
EP  - 965
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 14
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Biological Chemistry, Division of Basic Science, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 8667426.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107386255
T1  - Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly.
AU  - Losonczy KG
AU  - Harris TB
AU  - Havlik RJ
Y1  - 1996/08//
N1  - Accession Number: 107386255. Language: English. Entry Date: 19961001. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Mortality -- Epidemiology -- In Old Age
KW  - Coronary Disease -- Mortality -- In Old Age
KW  - Vitamin E -- Administration and Dosage -- In Old Age
KW  - Ascorbic Acid -- Administration and Dosage -- In Old Age
KW  - Ascorbic Acid -- Therapeutic Use -- In Old Age
KW  - Vitamin E -- Therapeutic Use -- In Old Age
KW  - Neoplasms -- Mortality -- In Old Age
KW  - Dietary Supplementation -- In Old Age
KW  - Risk Factors -- In Old Age
KW  - Epidemiological Research
KW  - Interviews
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Descriptive Statistics
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 190
EP  - 196
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 64
IS  - 2
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - We examined vitamin E and vitamin C supplement use in relation to mortality risk and whether vitamin C enhanced the effects of vitamin E in 11 178 persons aged 67-105 y who participated in the Established Populations for Epidemiologic Studies of the Elderly in 1984-1993. Participants were asked to report all nonprescription drugs currently used, including vitamin supplements. Persons were defined as users of these supplements if they reported individual vitamin E and/or vitamin C use, not part of a multivitamin. During the follow-up period there were 3490 deaths. Use of vitamin E reduced the risk of all-cause mortality [relative risk (RR) = 0.66; 95% CI: 0.53, 0.83] and risk of coronary disease mortality (RR = 0.53; 95% CI: 0.34, 0.84). Use of vitamin E at two points in time was also associated with reduced risk of total mortality compared with that in persons who did not use any vitamin supplements. Effects were strongest for coronary heart disease mortality (RR = 0.37; 95% CI: 0.15, 0.90). The RR for cancer mortality was 0.41 (95% CI: 0.15, 1.08). Simultaneous use of vitamins E and C was associated with a lower risk of total mortality (RR = 0.58; 95% CI: 0.42, 0.79) and coronary mortality (RR = 0.47; 95% CI: 0.25, 0.87). Adjustment for alcohol use, smoking history, aspirin use, and medical conditions did not substantially alter these findings. These findings are consistent with those for younger persons and suggest protective effects of vitamin E supplements in the elderly. (c) 1996 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Epidemiology, Demograpy and Biometry Program, National Institute on Aging, Gateway Building, Room 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892-9205, E-mail: klosoncz@gibbs.oit.unc.edu
U2  - PMID: 8694019.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Gourevitch, Marc N.
AU  - Hartel, Diana
AU  - Schoenbaum, Ellie E.
AU  - Selwyn, Peter A.
AU  - Davenny, Katherine
AU  - Friedland, Gerald H.
AU  - Klein, Robert S.
T1  - A Prospective Study of Syphilis and HIV Infection among Injection Drug Users Receiving Methadone in the Bronx, NY.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/08//Aug1996 Part 1 of 2
VL  - 86
IS  - 8
M3  - Article
SP  - 1112
EP  - 1115
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. The purpose of this study was to assess the relationship between syphilis and human immunodeficiency virus (HIV) infection in injection drug users. Methods. A 6-year prospective study of 790 injection drug users receiving methadone maintenance treatment in the Bronx, NY, was conducted. Results. Sixteen percent (4/25) of HIV-seroconverting patients, 4.8% (16/335) of prevalent HIV-seropositive patients, and 3.5% (15/430) of persistently HIV-seronegative patients were diagnosed with syphilis. Incidence rates for early syphilis (cases per 1000 person-years) were 15.9 for HIV-seroconverting patients, 8.9 for prevalent HIV-seropositive patients, and 2.9 for persistently HIV-seronegative patients. Early syphilis incidence was higher among women than men (8.4 vs 3.2 cases per 1000 person-years). Independent risks for early syphilis included multiple sex partners, HIV seroconversion, paid sex, and young age. All HIV seroconverters with syphilis were female. Conclusions. Diagnosis of syphilis in drug-using women reflects high-risk sexual activity and is associated with acquiring HIV infection. Interventions to reduce the risk of sexually acquired infections are urgently needed among female drug users. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SYPHILIS
KW  - SEXUALLY transmitted diseases
KW  - HIV infections
KW  - DRUG abuse
KW  - METHADONE abuse
N1  - Accession Number: 9608296817; Gourevitch, Marc N. 1 Hartel, Diana 1 Schoenbaum, Ellie E. 1 Selwyn, Peter A. 2 Davenny, Katherine 3 Friedland, Gerald H. 2 Klein, Robert S. 1; Affiliation:  1: Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY  2: Yale--New Haven Hospital, Yale University School of Medicine, New Haven, Conn.  3: National Institute on Drug Abuse, National Institutes of Health, Rockville, Md.; Source Info: Aug1996 Part 1 of 2, Vol. 86 Issue 8, p1112; Subject Term: SYPHILIS; Subject Term: SEXUALLY transmitted diseases; Subject Term: HIV infections; Subject Term: DRUG abuse; Subject Term: METHADONE abuse; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3537
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
T1  - CULTURAL AND SOCIAL STRUCTURAL EXPLANATIONS OF CROSS-NATIONAL PSYCHOLOGICAL DIFFERENCES.
JO  - Annual Review of Sociology
JF  - Annual Review of Sociology
Y1  - 1996/08//
VL  - 22
M3  - Article
SP  - 323
PB  - Annual Reviews Inc.
SN  - 03600572
AB  - This chapter examines cross-national differences in individual values, attitudes, and behaviors. The central question raised is how social-structural and cultural factors account for the differences found. After discussing a series of theoretical issues raised by this question, the chapter reviews the findings of four quantitative sociological research programs on modem cross-national differences. The program on individual modernity led by Alex Inkeles established that social-structural conditions associated with industrialization are linked to an increase in individuals' being open to new experience, rejecting traditional authority, and taking a rational, ambitious, orderly approach to both work and human problems. The cross-national research on the Kohn-Schooler hypothesis that self-directed work increases intellectual functioning and self-directed orientations confirmed the generality of that hypothesis and established that the social status and social class differences in these psychological characteristics found within different countries are largely the result of social-structurally determined differences in the opportunity for occupational self-direction. Eric Wright's cross-national research program on class structure and class consciousness provides evidence that in a range of countries social classes directly affect political attitudes, while acting as tangible barriers to mobility and personal relationships. The research deriving from John Meyer's theories on institutionalization highlights the importance of institutions and socially constructed views of reality for the development and maintenance of cross-national differences and similarities in cultural values and their behavioral embodiment. All four of the programs provide evidence of the continuing importance of historically determined cultural differences. All are also congruent with the hypothesis that speed of change generally decreases as we go from psychological to social-structural to cultural levels of phenomena-a possibility whose confirmation would provide a valuable tool for understanding how culture and social structure affect cross-national differences in values and behavior. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annual Review of Sociology is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL structure
KW  - SOCIAL classes -- Research
KW  - SOCIAL status
KW  - CULTURAL relations
KW  - CROSS-cultural communication
KW  - SOCIAL psychology
KW  - attitudes
KW  - culture
KW  - psychological functioning
KW  - social structure
N1  - Accession Number: 9704023934; Schooler, Carmi 1; Affiliation:  1: Laboratory of Socio-Environmental Studies, National Institute of Mental Health, National Institutes of Health, Federal Building, Room B 1A14, 7550 Wisconsin Avenue, Bethesda, Maryland 20892.; Source Info: 1996, Vol. 22, p323; Subject Term: SOCIAL structure; Subject Term: SOCIAL classes -- Research; Subject Term: SOCIAL status; Subject Term: CULTURAL relations; Subject Term: CROSS-cultural communication; Subject Term: SOCIAL psychology; Author-Supplied Keyword: attitudes; Author-Supplied Keyword: culture; Author-Supplied Keyword: psychological functioning; Author-Supplied Keyword: social structure; Number of Pages: 26p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107383559
T1  - Teaching symptom management of HIV/AIDS using algorithms.
AU  - Lietzau J
Y1  - 1996/08//1996 Aug
N1  - Accession Number: 107383559. Language: English. Entry Date: 19961001. Revision Date: 20150820. Publication Type: Journal Article; algorithm. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Patient Education
KW  - HIV Education
KW  - Teaching Methods
KW  - Acquired Immunodeficiency Syndrome -- Symptoms
KW  - Algorithms
KW  - Nausea and Vomiting
KW  - Weight Loss
KW  - Sinusitis
KW  - Diarrhea
KW  - Neurologic Manifestations
SP  - 263
EP  - 268
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 19
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Management of patients infected with the human immunodeficiency virus (HIV) or with acquired immunodeficiency syndrome (AIDS) presents a complex set of challenges to the health-care professional, especially in the area of patient education Lack of resources, time constraints, and/or patients' willingness to learn about the disease are all factors that can impact the teaching/learning process. Creative and effective teaching strategies must be implemented so that adequate information and support is provided to the patient and/or the caregiver. Algorithms were developed for the patient and/or caregiver to use as a quick reference for decision making regarding symptom management of common manifestations of HIV/AIDS.
SN  - 0162-220X
AD  - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 8768683.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Shindo, M.
AU  - Mullin, G. E.
AU  - Braun-Elwert, L.
AU  - Bergasa, N. V.
AU  - Jones, E. A.
AU  - James, S. P.
T1  - Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB).
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1996/08//
VL  - 105
IS  - 2
M3  - Article
SP  - 254
EP  - 259
PB  - Wiley-Blackwell
SN  - 00099104
AB  - The expression of cytokine mRNA species was determined in liver biopsies from six normal subjects. 18 patients with PBC and 14 patients with hepatitis B e antigen (HBeAg)-positive CHB using it reverse transcriptase-polymerase chain reaction (RT-PCR) technique, cDNA, obtained by reverse transcription using oligo d(T) primers, was amplified by PCR using primers specific for the coding region of seven different cytokines (IL-1, IL-2, IL-4, IL-5, IL-6, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α). The abundance of some cytokines (IL-2, IL-4, IL-5 and IFN-γ,) was also estimated by semiquantitative RT-PCR, using as standards dilutions of synthetic cytokine mRNA transcripts, that could be distinguished electrophoretically from respective native cytokine mRNAs. Hepatic inflammation was assessed by a semiquantitative histologic score and by amplification of mRNA for T cell receptor (TCR)-α mRNAs for IL-1 and IL-6 were detected in only one control liver. In CHB, mRNAs for IL-1, IL-2, IL-4, IL-5 and IFN-γ were detected in 43%, 60%, 80%, 20%, and 54% of biopsies, respectively. mRNA for IFN-γ and IL-4, but not IL- 1, tended to be associated with .severe inflammation. In five biopsies semiquantitative analyses revealed increased levels of mRNA for TCR-α and, when transcripts were detectable, high levels of mRNA for IFN-γ and IL-4. In PBC, mRNA for IFN-γ was detected in 60% of biopsies, but no mRNAs for IL-1, IL-2, IL-4, IL-5, or IL-6, or for TNF-α, were detected-Semiquantitative analyses revealed that absolute levels of mRNA for IFN-γ tended to correlate with the severity of hepatic inflammation. The results suggest that: (i) there may be fundamental differences in the roles that cytokines play in the hepatic inflammatory processes of PBC and CHB: and (ii) while hepatic IFN-γ mRNA expression is not specific for PBC, IFN-γ may play a prominent role in the immunopathogenesis of PBC. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MESSENGER RNA
KW  - CYTOKINES
KW  - CELLULAR immunity
KW  - LIVER diseases
KW  - POLYMERASE chain reaction
KW  - HEPATITIS B
KW  - cytokines mRNA liver biopsy primary biliary cirrhosis hepatitis B
N1  - Accession Number: 15948891; Shindo, M. 1 Mullin, G. E. 2 Braun-Elwert, L. 2 Bergasa, N. V. 1 Jones, E. A. 3 James, S. P. 2; Affiliation:  1: Liver Diseases Section, NIDDK, National Institutes of Health, Bethesda, MD, USA.  2: Mucosal Immunity Section, NIAID, National Institutes of Health, Bethesda, MD, USA.  3: Department of Gastrointestinal and Liver Diseases, Academic Medical Centre, Amsterdam, Nelherlatids.; Source Info: Aug1996, Vol. 105 Issue 2, p254; Subject Term: MESSENGER RNA; Subject Term: CYTOKINES; Subject Term: CELLULAR immunity; Subject Term: LIVER diseases; Subject Term: POLYMERASE chain reaction; Subject Term: HEPATITIS B; Author-Supplied Keyword: cytokines mRNA liver biopsy primary biliary cirrhosis hepatitis B; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zhang, Jian Q.
AU  - Luo, Gang
AU  - Herrera, Amy H.
AU  - Paterson, Bruce
AU  - Horowits, Robert
T1  - cDNA cloning of mouse nebulin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1996/08//8/1/96
VL  - 239
IS  - 3
M3  - Article
SP  - 835
EP  - 841
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Nebulin is a family of giant myofibrillar proteins with molecular masses ranging over 700-900 kDa, Using a human nebulin cDNA probe. we isolated three nebulin cDNA clones from a mouse skeletal muscle cDNA library These three clones, labeled 8c. 7a and 4b, carry inserts of 2.0. 3.0 and 3.5 kb, respectively. In Northern blots, each insert detected the same &ap;25 Kb message from skeletal muscle as the human nebulin probe. while detecting no messages from cardiac muscle. Sequence data in combination with reverse-transcriptase PCR indicates that Clones 7a and 8c overlap to form 4076 bp contiguous sequence Alignment with the published full-length human nebulin sequence indicates that clone 7a over 1596bp. Howover after the first 798-bp overlap the sequence of these two mouse nebulin clones diverge. suggesting that they derive from distinct transcripts encoding isoforms of mouse nebulin The mouse nebulin clones encode a series of &ap;245 residue super repeats. each of which can he subdivided into seven &ap;35-residue, weakly repeating modules centered around a conserved tyrosine residue, consistent with the human nebulin sequence. The mouse nebulin clones align along the central third of the full-length human sequence. corresponding to super repeats 8- 16 of the 22 super repeats found in human nebulin The translated sequence is greater than 90% identical to the human sequence. with the exception of a 200-amino-acid region at the C-terminus of done 4b which is less than 60% identical, In genomic Southern blots. a mouse nebulin probe detected a homologous sequence in a wide variety of vertebrate species under stringent conditions However, no significant hybridization was observed to genomic DNA from invertebrates and microorganisms. even under very low stringency The sequence and Southern-blot data suggest that the nebulin sequence is highly conserved among vertebrate species. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOLECULAR cloning
KW  - RATS
KW  - PROTEINS
KW  - TRANSCRIPTION factors
KW  - MOLECULAR genetics
KW  - BIOMOLECULES
KW  - cDNA
KW  - muscle.
KW  - nebulin
N1  - Accession Number: 12950795; Zhang, Jian Q. 1 Luo, Gang 1 Herrera, Amy H. 1 Paterson, Bruce 2 Horowits, Robert 1; Affiliation:  1: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of health, USA.  2: National Cancer Institute, National Institute of Health, USA.; Source Info: 8/1/96, Vol. 239 Issue 3, p835; Subject Term: MOLECULAR cloning; Subject Term: RATS; Subject Term: PROTEINS; Subject Term: TRANSCRIPTION factors; Subject Term: MOLECULAR genetics; Subject Term: BIOMOLECULES; Author-Supplied Keyword: cDNA; Author-Supplied Keyword: muscle.; Author-Supplied Keyword: nebulin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Silver, R. F.
AU  - Crystal, R. G.
AU  - Moller, D. R.
T1  - Limited heterogeneity of biased T-cell receptor Vβ gene usage in lung but not blood T cells in active pulmonary sarcoidosis.
JO  - Immunology
JF  - Immunology
Y1  - 1996/08//
VL  - 88
IS  - 4
M3  - Article
SP  - 516
EP  - 523
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Sarcoidosis is a multisystem disorder characterized by non-caseating granulomas and the accumulation of CD4+ T cells in involved tissues such as the lung. To evaluate the diversity of the CD4+ T-cell repertoire in this disorder, a detailed clonal analysis was performed in five individuals with active sarcoidosis who demonstrated preferential accumulation oft cells expressing the T-cell receptor variable gene family Vβ8 in either the lung or blood. In three individuals, analysis of unselected samples of nucleotide sequences derived from Vβ8+ lung T cells demonstrated degrees of clonality ranging from 11% to 46%, indicating the expansion of limited numbers of Vβ8+ T-cell clones in the lung. Analysis of the corresponding deduced amino acid sequences demonstrated common VDJ junctional amino acid residues in the dominant Vβ8+ T-cell clones derived from two oligoclonal Vβ8+ lung T-cell populations, consistent with an antigen-specific T-cell response. In contrast, analysis of Vβ8+ CD4+ T cells from the blood of an individual with a marked bias for peripheral blood Vβ8+ T cells demonstrated no evidence of oligoclonality, suggesting that the stimulus for circulating biased Vβ-specific T cells in sareoidosis may derive from a different, perhaps superantigenic, origin. Clinical improvement in the disease either in response to treatment with corticosteroids or as a result of spontaneous resolution was associated with a decrease in the proportion of Vβ8-specific T cells in the biased lung and/or blood T-cell compartments. Together, these observations are consistent with a role for this T-cell subset in the clinical manifestations of active granulomatous disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SARCOIDOSIS
KW  - T cells
KW  - CD4 antigen
KW  - T cell receptors
KW  - CHRONIC granulomatous disease
KW  - GENES
N1  - Accession Number: 14088809; Silver, R. F. 1,2 Crystal, R. G. 3,4 Moller, D. R. 1; Affiliation:  1: Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore  2: Division of Infectious Diseases, Case Western Reserve University, Biomedical Research Building 10W, 10900 Euclid Avenue, Cleveland, OH 44106, USA  3: Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA  4: Division of Pulmonary and Critical Care Medicine, The New York Hospital-Cornell Medical Center, 520 East 70 Street, Suite 505, New York, NY 10021, USA; Source Info: Aug96, Vol. 88 Issue 4, p516; Subject Term: SARCOIDOSIS; Subject Term: T cells; Subject Term: CD4 antigen; Subject Term: T cell receptors; Subject Term: CHRONIC granulomatous disease; Subject Term: GENES; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107338262
T1  - Hospital and nursing home use in the last three months of life.
AU  - Brock DB
AU  - Foley DJ
AU  - Salive ME
Y1  - 1996/08//
N1  - Accession Number: 107338262. Language: English. Entry Date: 19971001. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported by the National Institute on Aging, Bethesda, Maryland, through contract number NO1-AG-2-2137. NLM UID: 8912686. 
KW  - Death -- In Old Age
KW  - Community Living -- In Old Age
KW  - Aged, Hospitalized
KW  - Institutionalization -- In Old Age
KW  - Long Term Care
KW  - Funding Source
KW  - Secondary Analysis
KW  - Telephone
KW  - Interviews
KW  - Descriptive Statistics
KW  - Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Goodness of Fit Chi Square Test
KW  - Retrospective Design
KW  - Record Review
KW  - Risk Factors
KW  - Nursing Homes
KW  - Connecticut
KW  - Length of Stay
KW  - Dementia -- In Old Age
KW  - Social Isolation -- In Old Age
KW  - Incontinence -- In Old Age
KW  - Data Analysis Software
KW  - Sampling Methods
KW  - Aged
KW  - Aged, 80 and Over
KW  - Inpatients
KW  - Outpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 307
EP  - 319
JO  - Journal of Aging & Health
JF  - Journal of Aging & Health
JA  - J AGING HEALTH
VL  - 8
IS  - 3
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0898-2643
AD  - Rm 3C-309 Bethesda Gateway Bldg, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD 20892-9205
U2  - PMID: 10165977.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107389221
T1  - Report on the activities of the Milan World Health Organization Collaborating Center.
AU  - Ventafridda V
AU  - De Conno F
Y1  - 1996/08//1996 Aug
N1  - Accession Number: 107389221. Language: English. Entry Date: 19961101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836. 
KW  - World Health Organization -- Italy
KW  - Interprofessional Relations
KW  - Organizational Policies
KW  - Palliative Care -- Organizations
KW  - Italy
KW  - Publishing
KW  - Meetings
SP  - 79
EP  - 81
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 12
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
SN  - 0885-3924
AD  - WHO Collaborating Center, National Cancer Institute, Via Venezian 1, 20133, Milan, Italy
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107389225
T1  - Report of the European Association for Palliative Care.
AU  - Blumhuber H
AU  - De Conno F
AU  - Hanks GW
Y1  - 1996/08//1996 Aug
N1  - Accession Number: 107389225. Language: English. Entry Date: 19961101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836. 
KW  - Palliative Care -- Organizations -- Europe
KW  - Reports
KW  - Interinstitutional Relations
KW  - Goals and Objectives -- Evaluation
KW  - Europe
KW  - Congresses and Conferences
KW  - Serial Publications
SP  - 82
EP  - 84
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 12
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
SN  - 0885-3924
AD  - EAPC, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy
U2  - PMID: 8754984.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107312345
T1  - Report from the NIA. Longevity assurance genes: how do they influence aging and life span?
AU  - Hodes RJ
AU  - McCormick AM
AU  - Pruzan M
Y1  - 1996/08//8/ 1/1996
N1  - Accession Number: 107312345. Language: English. Entry Date: 19970201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Longevity
KW  - Genes
KW  - Aging
KW  - Yeasts
KW  - Mice
SP  - 988
EP  - 991
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0002-8614
AD  - National Institute on Aging, Bldg 31, Rm 5C35, Center Drive, MSC2292, Bethesda, MD 20892
U2  - PMID: 8708315.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107278802
T1  - Office of Research on Women's Health: National Institutes of Health.
AU  - Chunko MT
AU  - Hayunga E
AU  - Rothenberg K
AU  - Rudick J
AU  - Pinn VW
Y1  - 1996/08//1996 Aug
N1  - Accession Number: 107278802. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; directories. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Women's Health
KW  - National Institutes of Health (U.S.)
KW  - Research, Medical
KW  - Clinical Research -- Economics
KW  - Female
KW  - Genetic Screening
KW  - Career Planning and Development
KW  - Grants
KW  - Training Support, Financial
KW  - United States
SP  - 317
EP  - 323
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 5
IS  - 4
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1059-7115
AD  - Office of Research on Women's Health, National Institutes of Health, 9000 Rockville Pike, Building 1, Room 201, Bethesda, Maryland 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107310055
T1  - The nursing practice environment, staff retention, and quality of care.
AU  - Leveck ML
AU  - Jones CB
Y1  - 1996/08//
N1  - Accession Number: 107310055. Language: English. Entry Date: 19970201. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Organizational Work Satisfaction Scale; Nursing Job Satisfaction Scale (Atwood and Hinshaw); Likert's Profile of Organizational Characteristics (POC); Group Cohesion scale (Good and Nelson); Phaneuf Nursing Audit (Phaneuf); Job Stress Scale (Hinshaw and Atwood). Grant Information: National Center for Nursing Research, NIH (K07 NR00008). NLM UID: 7806136. 
KW  - Management Styles
KW  - Nursing Practice
KW  - Stress, Occupational
KW  - Nursing Staff, Hospital
KW  - Job Satisfaction
KW  - Quality of Nursing Care
KW  - Work Environment
KW  - Personnel Retention
KW  - Content Validity
KW  - Organizational Culture
KW  - Funding Source
KW  - Cross Sectional Studies
KW  - Models, Theoretical
KW  - Research Instruments
KW  - Scales
KW  - Summated Rating Scaling
KW  - Nursing Audit
KW  - Descriptive Statistics
KW  - Coefficient Alpha
KW  - Internal Consistency
KW  - Human
SP  - 331
EP  - 343
JO  - Research in Nursing & Health
JF  - Research in Nursing & Health
JA  - RES NURS HEALTH
VL  - 19
IS  - 4
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
AB  - OBJECTIVE: Organizational change in hospitals raises two important questions: (a) Are health care organizations jeopardizing quality of care?; and (b) Are health care organizations setting the stage for future registered nurse (RN) shortages? The purpose of this study was to provide a foundation for answering these questions by exploring relationships between the practice environment, quality of nursing care, and the retention of RN staff on nursing units. DESIGN: Cross-sectional structural equation modeling design. SETTING: Four acute care hospitals in a southeastern United States metropolitan area. All 63 inpatient nursing units at these four hospitals were included in the initial study sample. POPULATION: Every staff RN employed on these 63 units who (a) was employed full-time and (b) had been employed on the unit a minimum of 3 months were asked to participate. Data from 50 units met the response rate criteria for inclusion. Returned questionnaires were obtained from 358 of the 611 nurses (59%). INTERVENTIONS: Questionnaire packets were distributed to all 670 staff nurses. Nurses were asked to respond based upon their perceptions of the work unit. Several instruments were included in the packet to measure the practice environment, including the Group Cohesion Scale, Job Stress Scale, Organizational Work Satisfaction Scale, Nursing Job Satisfaction Scale, and others. Quality of care was assessed on a unit basis using a retrospective audit of patient charts by research assistants. MAIN OUTCOME MEASURE(S): The findings point to several important issues related to working conditions and the practice environment, and provide direction for developing strategies to address these concerns. First, units where nurses perceived a participative management style reported higher levels of group cohesion and lower levels of job stress; decreased job stress was found to increase quality of nursing care. Second, participative management also explained nurses' perception of organizational job satisfaction at the unit level. Third, nurses employed on medical-surgical units perceived higher levels of job stress than nurses employed on other types of specialty units. Fourth, the theoretical model helps explain staff nurse retention and quality of care and provides insight into the complex nature of these variables. Staff retention was explained by two factors: experience on the unit and professional job satisfaction. RESULTS/CONCLUSIONS: As with all studies of this nature, certain limitations are recognized. First, the sample size is of concern, even though it was larger than most previous samples. Second, the quality of care measure employed in this study is a concern, given that a retrospective chart audit may assess the quality of the chart rather than the quality of care delivered. Third, content validity and representativeness were of concern in this study, while the criteria of reliability and validity clearly were satisfied. The findings point to several opportunities for future research. Future investigations should focus on obtaining a larger sample, developing and utilizing quality of care measures that are less dependent upon chart documentation of nursing care, expanding the model to incorporate other important variables, and revising or designing instruments with the organizational unit in mind. [CINAHL abstract]
SN  - 0160-6891
AD  - Health Scientist Administrator, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8773556.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107310055&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00871-001
AN  - 2006-00871-001
AU  - Calogero, A. E.
AU  - Scaccianoce, S.
AU  - Burrello, N.
AU  - Nicolai, R.
AU  - Muscolo, L. A. A.
AU  - Kling, M. A.
AU  - Angelucci, L.
AU  - D'Agata, R.
T1  - The kappa-opioid receptor agonist MR-2034 stimulates the rat hypothalamic-pituitary-adrenal axis: Studies in vivo and in vitro.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1996/08//
VL  - 8
IS  - 8
SP  - 579
EP  - 585
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - Calogero, A. E., Istituto di Clinica Medica I, Ospedale Garibaldi, Piazza S. Maria di Gesu, 95123, Catania, Italy
N1  - Accession Number: 2006-00871-001. PMID: 8866244 Partial author list: First Author & Affiliation: Calogero, A. E.; First Internal Medicine Department, University of Catania Medical School, Catania, Italy. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Scaccianoce, S. Major Descriptor: Hypothalamic Pituitary Adrenal Axis; Narcotic Agonists; Opiates. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 1996. 
AB  - There is increasing evidence that opiates not only have analgesic properties, but also regulate mechanisms activated during the stress response, such as the hypothalamic-pituitary-adrenal (HPA) axis. Indeed, opioid-containing neurons innervate the paraventricular nucleus and the median eminence, thus modulating inputs to ACTH-controlling neurons. In addition, dynorphin (the endogenous ligand of the kappa-opioid receptor)-like peptides have been found co-localized with corticotrophin-releasing hormone (CRH) and are believed to be co-secreted with it in the hypophyseal portal circulation to modulate ACTH release. In this study, we evaluated the effects of the selective κ-opioid receptor agonist MR-2034 [(-)-N-(2-tetrahydrofurfuryl)-normetazocine] on the HPA axis in vivo and in vitro. MR-2034 was given intravenously to catheterized, freely moving, male Sprague-Dawley rats and serial blood samples were collected for ACTH and corticosterone (B) measurements. We evaluated also the site of MR-2034 action on the HPA axis in vivo, after the administration of α-helical CRH9-41, a CRH receptor antagonist, on hypothalamic CRH, pituitary ACTH, and B release in vitro. MR-2034 increased plasma ACTH and B levels in a dose-related fashion and this effect was antagonized by the selective κ-opioid receptor antagonist MR-1452. In the presence of α-helical CRH9-41, the responses of plasma ACTH and B to MR-2034 were blunted significantly, suggesting that this compound activates the HPA axis through a CRH-dependent mechanism. Accordingly, MR-2034 stimulated hypothalamic CRH release in vitro in a concentration-dependent fashion and this effect was antagonized dose-dependently by MR-1452. However, the stimulatory effect of MR-2034 on plasma ACTH and B in vivo was not completely abolished by α-helical CRH9-41, suggesting that an additional, CRH-independent, mechanism was involved. Indeed, MR-2034 was able to stimulate basal ACTH output in a dose-dependent manner and this effect was antagonized by MR-1452 in vitro. On the other hand, MR-2034 did not have any effect on B release from adrenocortical cells or adrenal quarters in vitro. These results show that the benzomorphan MR-2034 stimulates the HPA axis in the rat by acting at the hypothalamic and the pituitary level. We hypothesize that endogenous κ-opioid peptides not only act at the pituitary level to increase ACTH output, but may also act at the hypothalamic level to increase CRH release through an autocrine and/or ultrashort positive feedback mechanism. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MR-2034
KW  - hypothalamic-pituitary-adrenal axis
KW  - rats
KW  - 1996
KW  - Hypothalamic Pituitary Adrenal Axis
KW  - Narcotic Agonists
KW  - Opiates
KW  - Rats
KW  - 1996
U1  - Sponsor: National Research Council. Grant: 92.003.69.40. Recipients: Scaccianoce, S.
U1  - Sponsor: Ministero dell'Universita e della Ricerca. Other Details: Ricerca Scientifica 40%, Progetto Nazionale di Ricerca 'Fisiopatologia Endocrina'. Recipients: Scaccianoce, S.
DO  - 10.1111/j.1365-2826.1996.tb00691.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00871-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17622-054
AN  - 2004-17622-054
AU  - Andreassen, Carol
AU  - Bornstein, Marc H.
T1  - An Invitation to Children's Storytelling.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1996/08//
VL  - 41
IS  - 8
SP  - 835
EP  - 836
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17622-054. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Andreassen, Carol; Child and Family Research Section, National Institute of Child Health and Human Development (NICHHD), Bethesda, MD, US. Release Date: 20041004. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Early Childhood Development; Language Development; Storytelling. Classification: Cognitive & Perceptual Development (2820). Reviewed Item: Herman, Ruth A.; Slobin, Dan Isaac. Relating Events in Narrative: A Crosslinguistic Developmental Study=Hillsdale, NJ: Erlbaum, 748 pp; 1994. References Available: Y. Page Count: 2. Issue Publication Date: Aug, 1996. 
AB  - The reviewer states that this book (see record [rid]1994-97555-000[/rid]) begins to redress certain general limitations and imbalances in research on early language development, such as a persistent focus on the first years, use of small sample sizes, and assumptions of cultural universalism in the language acquisition process. The research presented in this volume is descriptive and is guided by assumptions and expectations rather than by explicit hypotheses. In summary, a broad description of crosslinguistic development is proffered, methods specified and tools provided, findings overviewed, and some research questions raised. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - language acquisition process
KW  - language development
KW  - storytelling
KW  - early language development
KW  - crosslinguistic development
KW  - 1996
KW  - Early Childhood Development
KW  - Language Development
KW  - Storytelling
KW  - 1996
U2  - Herman, Ruth A.; Slobin, Dan Isaac. (1994); Relating Events in Narrative: A Crosslinguistic Developmental Study; Hillsdale, NJ: Erlbaum, 748 pp; 0-8058-1435-3.
DO  - 10.1037/003078
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17622-054&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13553-016
AN  - 2008-13553-016
AU  - Calvo, Charles-Félix
AU  - Yoshimura, Teizo
AU  - Gelrman, Michèle
AU  - Mallat, Michel
T1  - Production of monocyte chemotactic protein-1 by rat brain macrophages.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1996/08//
VL  - 8
IS  - 8
SP  - 1725
EP  - 1734
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Calvo, Charles-Félix, INSERM U114, College de France, 75231, Paris, France, Cedex 05
N1  - Accession Number: 2008-13553-016. PMID: 8921263 Partial author list: First Author & Affiliation: Calvo, Charles-Félix; INSERM U114, College de France, Paris, France. Other Publishers: Blackwell Publishing. Release Date: 20100927. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Calvo, Charles-Félix. Major Descriptor: Bone Marrow; Brain; Proteins. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Aug, 1996. Publication History: First Posted Date: Mar 15, 1996; Revised Date: Feb 20, 1996; First Submitted Date: Dec 5, 1995. Copyright Statement: European Neuroscience Association
AB  - In the present study, we show that cultured rat brain macrophages release a soluble factor that stimulates the migration of bone marrow-derived macrophages, as determined by an in vitro chemotaxis assay. A checkerboard analysis indicated that most of this effect resulted from a polarized migration of the cells (chemotactic phenomenon), rather than in an increase in cell motility (chemokinesis). This activity was significantly decreased by an immune serum directed against the rat monocyte chemoattractant protein-1 (chernokine MCP-1). Northern blot analysis demonstrated expression of the MCP-1 gene in cultured brain macrophages, but its absence in unstimulated bone marrow-derived macrophages. Up-regulation of MCP-1 expression was observed when lipopolysaccharide was added to cultured brain macrophages, a peak occurring after a 6 h period of stimulation. Also, inflammatory cytokines such as interleukin (IL)-1β, colony stimulating factor-1, tumour necrosis factor-α and IL-6 individually increased the basal level of MCP-1 mRNA. Subsequently, we demonstrated the in vivo production of MCP-1 in the adult rat brain following injury induced by a local injection of kainic acid. MCP-1 synthesis was localized in both astrocytes and brain macrophages. These results suggest that the activation of resting microglial cells into brain macrophages and their subsequent secretion of chemokines could contribute to the mechanism(s), leading to the infiltration of the CNS by blood-derived monocytes, as observed in several pathologies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - monocytes
KW  - chemotactic proteins
KW  - rats
KW  - brain
KW  - macrophages
KW  - bone marrow
KW  - 1996
KW  - Bone Marrow
KW  - Brain
KW  - Proteins
KW  - Rats
KW  - 1996
U1  - Sponsor: Institut National de la Santé et de la Recherche Médicale. Recipients: No recipient indicated
U1  - Sponsor: Agence Nationale de Recherches sur le SIDA. Recipients: No recipient indicated
U1  - Sponsor: Centre national de la recherche scientifique. Recipients: Calvo, Charles-Félix
DO  - 10.1111/j.1460-9568.1996.tb01316.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13553-016&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38425-017
AN  - 2015-38425-017
AU  - Van Bockstaele, Elisabeth J.
AU  - Colago, Eric E. O.
AU  - Cheng, Peter
AU  - Moriwaki, Akiyoshi
AU  - Uhl, George R.
AU  - Pickel, Virginia M.
T1  - Ultrastructural evidence for prominent distribution of the μ-opioid receptor at extrasynaptic sites on noradrenergic dendrites in the rat nucleus locus coeruleus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/08//
VL  - 16
IS  - 16
SP  - 5037
EP  - 5048
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Van Bockstaele, Elisabeth J., Division of Neurobiology, Cornell University Medical College, 411 East 69th Street, Room KB410, New York, NY, US, 10021
N1  - Accession Number: 2015-38425-017. PMID: 8756434 Partial author list: First Author & Affiliation: Van Bockstaele, Elisabeth J.; Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Van Bockstaele, Elisabeth J. Major Descriptor: Enkephalins; Morphine; Peptides; Rats. Minor Descriptor: Locus Ceruleus; Norepinephrine. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Aug, 1996. Publication History: Accepted Date: May 21, 1996; Revised Date: May 9, 1996; First Submitted Date: Feb 6, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - Physiological studies have indicated that agonists at the μ-opioid receptor (μOR), such as morphine or the endogenous peptide methionine⁵-enkephalin, can markedly decrease the spontaneous activity of noradrenergic neurons in the locus coeruleus (LC). Messenger RNA and protein for μOR are also densely expressed by LC neurons. During opiate withdrawal, increased discharge rates of LC neurons coincide with the expression of behavioral features associated with the opiate withdrawal syndrome. To better define the cellular sites for the physiological activation of μOR in the LC and its relation to afferent terminals, we examined the ultrastructural localization of μOR immunoreactivity in sections dually labeled for the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH). Immunogold–silver labeling for μOR (i-μOR) was localized to parasynaptic and extrasynaptic portions of the plasma membranes of perikarya and dendrites, many of which also contained immunolabeling for TH. The dendrites containing exclusively i-μOR were more numerous in the rostral pole of the LC. The i-μOR in dendrites with and without detectable TH immunoreactivity were usually postsynaptic to unlabeled axon terminals containing heterogeneous types of synaptic vesicles and forming asymmetric synaptic specializations characteristic of excitatory-type synapses. These results provide the first direct ultrastructural evidence that μOR is strategically localized to modulate the postsynaptic excitatory responses of catecholamine-containing neurons in the LC. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - norepinephrine
KW  - drug abuse
KW  - enkephalin
KW  - opiate
KW  - morphine
KW  - excitatory amino acid
KW  - 1996
KW  - Enkephalins
KW  - Morphine
KW  - Peptides
KW  - Rats
KW  - Locus Ceruleus
KW  - Norepinephrine
KW  - 1996
U1  - Sponsor: National Association for Research on Schizophrenia and Depression. Other Details: Young Investigator Award. Recipients: Van Bockstaele, Elisabeth J.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: R29 DA09082. Recipients: Van Bockstaele, Elisabeth J.
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH40342; MH00078. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: DA04600. Recipients: Pickel, Virginia M.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38425-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38425-033
AN  - 2015-38425-033
AU  - Murphy, Diane D.
AU  - Segal, Menahem
T1  - 'Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones': Correction.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/08//
VL  - 16
IS  - 16
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Segal, Menahem, Department of Neurobiology, Weizmann Institute, Rehovot, Israel, 76100
N1  - Accession Number: 2015-38425-033. Partial author list: First Author & Affiliation: Murphy, Diane D.; Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Dendrites; Estradiol; Hippocampus; Steroids. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Issue Publication Date: Aug, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - Reports an error in 'Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones' by Diane D. Murphy and Menahem Segal (The Journal of Neuroscience, 1996[Jul], Vol 16[13], 4059-4068). In the original article, a mistake was discovered in the presentation of the error bars in Figures 2-6. The correct SEMs are as follows, from left to right: Fig. 2: 0.568, 0.92, 0.285, 0.443, 0.871. Fig. 3: 0.288, 0.524, 0.247, 0.25, 0.288, 0.375. Fig. 4: 0.422, 0.345, 0.436, 0.361, 0.394. Fig. 5: 0.372, 0.492, 0.408, 0.643, 0.341, 0.344, 0.139, 0.507. Fig. 6: 0.292, 0.463, 0.256, 0.188, 0.23, 0.457, 0.423, 0.426. (The following abstract of the original article appeared in record [rid]2015-38422-002[/rid]). The effects of gonadal steroid hormones on dendritic spines were studied in hippocampal neurons that were dissociated and grown in culture for 2–3 weeks. Exposure to estradiol caused up to a twofold increase in dendritic spine density in these neurons. The effect of estradiol was stereospecific and blocked by the steroid antagonist tamoxifen. The estradiol-induced rise in spine density was blocked by the NMDA antagonist APV, but not by the AMPA/KA antagonist DNQX. The estradiol-induced rise in spine density was blocked by the serine/threonine kinase inhibitor H7, but not by the tyrosine kinase inhibitor genestein, and was partially mimicked by PMA, an activator of protein kinase C. Estradiol also caused an increase in the fluorescence intensity of synaptophysin-immunoreactive terminals, corresponding to presynaptic boutons. Finally, estradiol caused a rise in [Ca]i reactivity of the cultured neurons to topical application of glutamate. These studies are the first to examine receptor and second messenger regulation of dendritic spines, and they illustrate the viability of cultured neurons as a powerful test system to address issues related to the regulation of dendritic spine maturation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dendritic spines
KW  - estradiol
KW  - culture
KW  - hippocampal neurons
KW  - calcium
KW  - plasticity
KW  - 1996
KW  - Dendrites
KW  - Estradiol
KW  - Hippocampus
KW  - Steroids
KW  - Rats
KW  - 1996
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38425-033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107254758
T1  - Risks and benefits of alcohol use over the life span.
AU  - Dufour MC
Y1  - 1996/09//
N1  - Accession Number: 107254758. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0365245. 
KW  - Alcohol Drinking
KW  - Risk Factors -- Evaluation
KW  - Alcohols -- Adverse Effects
KW  - Alcohols -- Therapeutic Use
SP  - 145
EP  - 151
JO  - Alcohol Health & Research World
JF  - Alcohol Health & Research World
JA  - ALCOHOL HEALTH RES WORLD
VL  - 20
IS  - 3
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - Especially at low and moderate drinking levels, alcohol consumption can be associated with benefits (e.g., protection against coronary heart disease) as well as risks (e.g., increased risk of accidents). These benefits and risks may change across a person's life span. To determine the likely net outcome of alcohol consumption, one must weigh the probable risks and benefits for each drinker. These assessments are based on the individual drinker's consumption levels, his or her personal characteristics (e.g., age or preexisting risk factors for coronary heart disease), and subjective values as well as on social considerations. The validity of such assessments also depends on the accuracy with which alcohol consumption and alcohol-related consequences can be measured.
SN  - 0090-838X
AD  - Deputy Director of the National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Levine, Mark
T1  - Fruits and vegetables: there is no substitute.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1996/09//
VL  - 64
IS  - 3
M3  - Article
SP  - 381
EP  - 382
SN  - 00029165
N1  - Accession Number: 97176549; Levine, Mark 1; Affiliations: 1: Molecular and Clinical Nutrition Section, Diabetes Branch, Building 10, Room 4D-52-MSC1372, National Institutes of Health, Bethesda, MD 20892-1372; Issue Info: Sep96, Vol. 64 Issue 3, p381; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107389414
T1  - Patient resources. Sources of information about consent in cancer research.
AU  - Padberg RM
Y1  - 1996/09//1996 Sep-Oct
N1  - Accession Number: 107389414. Language: English. Entry Date: 19961101. Revision Date: 20150820. Publication Type: Journal Article; forms. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. NLM UID: 9312355. 
KW  - Consent (Research)
KW  - Research Ethics
KW  - Protection of Human Subjects
KW  - Information Resources
SP  - 281
EP  - 284
JO  - Cancer Practice
JF  - Cancer Practice
JA  - CANCER PRACT
VL  - 4
IS  - 5
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 1065-4704
AD  - Clinical Trials, National Cancer Institute, Bethesda, Maryland
U2  - PMID: 9004575.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107389414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105821332
T1  - Immunotherapy for non-Hodgkin's lymphoma.
AU  - Longo DL
Y1  - 1996/09//1996 Sep
N1  - Accession Number: 105821332. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007265. 
KW  - Immunotherapy
KW  - Lymphoma, Non-Hodgkin's -- Therapy
KW  - Animals
KW  - Antibodies -- Therapeutic Use
KW  - Antibodies, Monoclonal -- Therapeutic Use
KW  - Cytokines -- Therapeutic Use
KW  - Immunization
SP  - 353
EP  - 359
JO  - Current Opinion in Oncology
JF  - Current Opinion in Oncology
JA  - CURR OPIN ONCOL
VL  - 8
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Humanized monoclonal anti-CD20 has impressive activity and radioimmunoconjugates. Targeting the same molecule has led to prolonged remissions in both moderate and myeloablative doses. Idiotype-based vaccination has produced an apparent prolongation in disease-free and overall survival in selected patients with follicular lymphoma. Adoptive cellular therapy is active in the setting of Epstein-Barr virus-induced lymphoma after allogenic bone marrow transplantation. Improvements in each of these developments are readily in sight.
SN  - 1040-8746
AD  - National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA.
U2  - PMID: 8914801.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Katz, Martin M.
AU  - Koslow, Stephen H.
AU  - Frazer, Alan
T1  - Onset of antidepressant activity: Reexamining the structure of depression and multiple actions of drugs.
JO  - Depression & Anxiety (1091-4269)
JF  - Depression & Anxiety (1091-4269)
Y1  - 1996/09//1996/97
VL  - 4
IS  - 6
M3  - Article
SP  - 257
EP  - 267
PB  - John Wiley & Sons, Inc.
SN  - 10914269
AB  - The question of when antidepressant drugs (AD) initiate significant clinical actions in depressed patients is still unsettled. Findings from early studies on whether there is a lag in the onset of therapeutic actions were in disagreement. More recent results with the selective serotonin reuptake inhibitors (SSRIs) and other new Ads indicate that clinical actions occur within the first 2 weeks. In this paper, evidence from efficacy studies with the Ads is reviewed and the methodologic and conceptual obstacles to achieving definitive results about the onset issue are analyzed. Depression, formerly viewed as a homogenous disorder, is now seen as heterogenous and multifaceted in structure. Such major structural components as anxiety and disturbed psychomotor functioning can be as significant to the core of the disorder as depressed mood itself. Further, the Ads have been shown to act initially on different facets of the clinical disorder which then result in multiple clinical actions, e.g., an initial reduction in anxiety followed by stimulation of motor activity. Data from the NIMH Collaborative Study of the Psychobiology of Depression are used to illustrate: (1) the componential structure of severe depressive disorder; (2) the sequence of change in the major behavioral components of the disorder associated with the tricyclic drugs; (3) the consequent ‘multiple’ onsets of clinical actions; and (4) measurement of the clinical significance and visibility of the early behavioral changes. Recent results describing new behavioral and methodological approaches, the use of early clinical changes to predict outcome, and strategies for designing sound studies of onset are discussed.Depression and Anxiety 4:257–267, 1996/1997.© 1997 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Depression & Anxiety (1091-4269) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIDEPRESSANTS
KW  - PATIENTS
KW  - THERAPEUTICS
KW  - PSYCHOBIOLOGY
KW  - ANXIETY
KW  - SEROTONIN
N1  - Accession Number: 11781893; Katz, Martin M. 1 Koslow, Stephen H. 2 Frazer, Alan 3; Affiliation:  1: Department of Psychiatry, Albert Einstein College of Medicine-Montefiore Medical Center, New York, New York.  2: Division of Neurosciences and Behavioral Sciences, National Institute of Mental Health, Rockville, Maryland.  3: Department of Pharmacology, University of Texas Health Sciences Center at San Antonio & Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas.; Source Info: 1996/97, Vol. 4 Issue 6, p257; Subject Term: ANTIDEPRESSANTS; Subject Term: PATIENTS; Subject Term: THERAPEUTICS; Subject Term: PSYCHOBIOLOGY; Subject Term: ANXIETY; Subject Term: SEROTONIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 11p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - AHMED, AHMED E.
AU  - JACOB, SAM
AU  - GHANAYEM, BURHAN I.
T1  - Comparative Disposition of Acrylonitrile and Methacrylonitrile: Quantitative Whole-Body Autoradiographic Studies in Rats.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/09//
VL  - 33
IS  - 1
M3  - Article
SP  - 49
EP  - 59
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Following intravenous administration of an equimolar (0.216 mmol/kg) radioactive dose of acrylonitrile (2-[14C]VCN, 11.5 mg/kg) or methacrylonitrile (2-[14C]MeVCN, 14.5 mg/kg), the tissue distribution, covalent interaction, and elimination were compared (at 5 mm to 48 hr) in male Fischer 344 rats using whole-body autoradiography (WBA). Autoradiographs obtained from freezedried or acid-extracted sections of animals treated with 2-[14C]VCN showed that radioactivity accumulated in the liver, lung, bone marrow, adipose tissues, kidney, gastrointestinal tract, and spleen. In animals treated with 2-[14C]MeVCN, the respiratory tissues contained high levels of 14C at an early period (5 min), while the gastrointestinal mucosa, adrenal cortex, liver, and kidney contained high levels of radioactivity at later periods (8, 24, and 48 hr). Quantitatively, lower uptake and irreversible interactions of 14C were observed in autoradiographs of rats treated with 2-[14C]MeVCN, compared with those treated with 2-[14C]VCN. Rats given 2-[14C]VCN eliminated only 27% of administered radioactivity (exhaled air, urine, and feces), whereas rats treated with 2-[14C]MeVCN eliminated, by all routes, 65% of the total radioactive dose. Both WBA and elimination studies indicated that 2-[14C]VCN and/or its metabolites were rapidly distributed, extensively bound, and slowly eliminated from tissues. 2-[14C]MeVCN and/or its metabolites, however, were rapidly distributed and eliminated, mostly via the lung. The study indicated that the substitution of a methyl group on the α-carbon of the α–β unsaturated aliphatic nitrile VCN, to form MeVCN, imparted qualitative and quantitative differences in the disposition of these two compounds. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Methacrylonitrile
KW  - Acrylonitrile
KW  - Radioactivity
KW  - Rats as laboratory animals
KW  - Autoradiography
N1  - Accession Number: 82425348; AHMED, AHMED E. 1; JACOB, SAM 1; GHANAYEM, BURHAN I. 2; Affiliations: 1: Department of Pathology, University of Medical Branch Galveston, Texas 77555–0605; 2: † National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; Issue Info: 1996, Vol. 33 Issue 1, p49; Thesaurus Term: Methacrylonitrile; Thesaurus Term: Acrylonitrile; Thesaurus Term: Radioactivity; Subject Term: Rats as laboratory animals; Subject Term: Autoradiography; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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ER  - 

TY  - JOUR
ID  - 107312682
T1  - Rapid identification of respiratory viruses: impact on isolation practices and transmission among immunocompromised pediatric patients [corrected] [published erratum appears in INFECT CONTROL HOSP EPIDEMIOL 1996 Dec; 17(12): 774].
AU  - Beekmann SE
AU  - Engler HD
AU  - Collins AS
AU  - Canosa J
AU  - Henderson DK
AU  - Freifeld A
Y1  - 1996/09//1996 Sep
N1  - Accession Number: 107312682. Language: English. Entry Date: 19970301. Revision Date: 20150818. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099. 
KW  - Patient Isolation -- In Infancy and Childhood
KW  - Cross Infection -- Prevention and Control -- In Infancy and Childhood
KW  - Respiratory Syncytial Virus Infections -- Prevention and Control -- In Infancy and Childhood
KW  - Influenza -- Prevention and Control -- In Infancy and Childhood
KW  - Retrospective Design
KW  - Prospective Studies
KW  - Microbial Culture and Sensitivity Tests
KW  - Time Factors
KW  - Descriptive Statistics
KW  - Hospitals -- Maryland
KW  - Maryland
KW  - Record Review
KW  - Specimen Handling
KW  - Immunoassay
KW  - Orthomyxoviridae
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Inpatients
KW  - Human
SP  - 581
EP  - 586
JO  - Infection Control & Hospital Epidemiology
JF  - Infection Control & Hospital Epidemiology
JA  - INFECT CONTROL HOSP EPIDEMIOL
VL  - 17
IS  - 9
PB  - Cambridge University Press
AB  - OBJECTIVE: To determine whether empiric isolation of patients with acute respiratory virus infection symptoms could be discontinued when preliminary shell vial cultures were negative, and the impact of this approach on hospital resources. DESIGN: In 1993, we retrospectively reviewed respiratory virus test results from 1992 to 1993 and extended data collection prospectively through the 1993 to 1994 season. The rapid test and 48-hour shell vial results were compared to a standard of rapid test plus 5-day shell vial culture results to determine the sensitivity and specificity of these 'preliminary' results. SETTING: A 400-bed tertiary referral research hospital. PATIENTS: Patients from any inpatient unit or clinic with acute respiratory virus infection symptoms who had a specimen submitted for respiratory virus culture. Patients were placed on empiric respiratory isolation pending culture results. RESULTS: The overall sensitivity of the combined rapid and 48-hour culture results in adults and children was 97%. All 15 pediatric patients with respiratory syncytial virus infection who had specimens submitted on first suspicion of respiratory virus infection were positive by rapid test. Culture results were positive within 48 hours for 100% of patients with influenza A (15 patients), influenza B (6), and parainfluenza (18) viruses. Of 59 pediatric inpatients who were isolated empirically awaiting 5-day culture results, 31 (52%) ultimately were determined to be culture negative. CONCLUSIONS: Empiric isolation of symptomatic children can be discontinued at 48 hours when both the rapid test and the early culture results are negative. Our institution would have saved 93 days of unnecessary isolation over 2 years had such a policy been in place.
SN  - 0899-823X
AD  - Hospital Epidemiology Service, National Cancer Institute, Institutes of Health, Bethesda, Maryland
U2  - PMID: 8880230.
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ER  - 

TY  - JOUR
ID  - 107351792
T1  - Varicella-zoster virus: the virus.
AU  - Cohen JI
Y1  - 1996/09//1996 Sep
N1  - Accession Number: 107351792. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Chickenpox -- Microbiology
KW  - Herpes Zoster -- Microbiology
KW  - Proteins
SP  - 457
EP  - 468
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 10
IS  - 3
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0891-5520
AD  - Building 10, Room 11N214, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 8856347.
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ER  - 

TY  - JOUR
AU  - Sommers, Ira
AU  - Baskin, Deborah
AU  - Fagan, Jeffrey
T1  - THE STRUCTURAL RELATIONSHIP BETWEEN DRUG USE, DRUG DEALING, AND OTHER INCOME SUPPORT ACTIVITIES AMONG WOMEN DRUG SELLERS.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1996///Fall96
VL  - 26
IS  - 4
M3  - Article
SP  - 975
EP  - 1006
SN  - 00220426
AB  - Interviews were conducted with 156 women drug sellers from two New York City neighborhoods with high concentrations of drug selling, neighborhoods that had active heroin markets in the 1970s and were sites for the growth of cocaine and crack markets a decade later. Structural equations models were estimated to test the relationships over two time periods between drug use and income generation activities including drug dealing, crime, legal work, and public transfers. Dependent variables included self-reports of income and expenses together with criminal career parameters. Results showed that the effects of prior drug expenses on subsequent crime, drug, and work incomes were nonsignificant. Overall, drug dealing appears to suppress future non-drug crime activity. Prior drug selling has a facilitating effect on later drug use and significant negative effects on subsequent crime income generation and legal work. Selling also helped women avoid the types of street hustling, including prostitution, and other crimes that characterized women's income strategies in earlier drug eras. Drug use careers are influenced less by earlier drug use patterns than by income growth from dealing that appears to increase opportunities to expand drug use. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WOMEN drug dealers
KW  - DRUG traffic
KW  - DRUGS & crime
KW  - DRUG abuse
KW  - NEW York (N.Y.)
KW  - NEW York (State)
N1  - Accession Number: 9701230511; Sommers, Ira 1,2 Baskin, Deborah 2,3 Fagan, Jeffrey 4; Affiliation:  1: Associate professor, Department of Criminal Justice of California State University, Los Angeles  2: Co-principal investigator, National Institute on Drug Abuse  3: Professor and Chair, Department of Criminal Justice of California State University, Los Angeles  4: Director of the Center of violence Studies, Columbia University; Source Info: Fall96, Vol. 26 Issue 4, p975; Subject Term: WOMEN drug dealers; Subject Term: DRUG traffic; Subject Term: DRUGS & crime; Subject Term: DRUG abuse; Subject Term: NEW York (N.Y.); Subject Term: NEW York (State); Number of Pages: 32p; Illustrations: 1 Diagram, 7 Charts; Document Type: Article; Full Text Word Count: 10950
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ER  - 

TY  - JOUR
ID  - 105854408
T1  - High end tidal CO2 association with blood pressure response to sodium loading in older adults.
AU  - Anderson DE
AU  - Dhokalia A
AU  - Parsons DJ
AU  - Bagrov AY
Y1  - 1996/09//1996 Sep
N1  - Accession Number: 105854408. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8306882. 
KW  - Blood Pressure
KW  - Carbon Dioxide -- Analysis
KW  - Sodium Chloride, Dietary -- Administration and Dosage
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Body Weight
KW  - Female
KW  - Heart Rate
KW  - Male
KW  - Middle Age
KW  - Regression
KW  - Human
SP  - 1073
EP  - 1079
JO  - Journal of Hypertension
JF  - Journal of Hypertension
JA  - J HYPERTENS
VL  - 14
IS  - 9
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - OBJECTIVE: To test the hypothesis that blood pressure of older adults with high resting end tidal CO2 (PETCO2) is sensitive to high dietary intake of sodium chloride. DESIGN AND METHODS: Forty-four Caucasian men and women, aged 41-79 years (mean +/- SEM 55.5 +/- 1.4), restricted their dietary intake of sodium chloride for 11 days and ingested sodium chloride capsules (an additional 190 mmol sodium/day) during the last seven of those days. On days 1, 4 and 11, resting PETCO2 and blood pressure were monitored for 25 min in the laboratory, followed by ambulatory blood pressure monitoring in the natural environment for 24 h. Overnight urine samples were obtained at days 4 and 11 to estimate excretion of sodium and of an endogenous digitalis-like factor (EDLF) that is sensitive to changes in plasma volume. RESULTS: Individual resting PETCO2 remained stable within and between laboratory monitoring sessions and was correlated with urinary excretion of the endogenous digitalis-like factor, both before and after the period of high sodium intake. The high-sodium diet was associated with increased urinary sodium excretion and body weight in all quartiles of PETCO2. The high-sodium diet produced significant increases in resting and in 24 h systolic blood pressures in the upper two quartiles of the PETCO2 distribution, and significant increases in resting and in 24 h diastolic blood pressures in the highest PETCO2 quartile only. CONCLUSION: These findings indicate blood pressure sensitivity to sodium loading is differentially associated with high resting PETCO2 in older adults. A high PETCO2 may be an index of a dynamic steady state that influences sodium transport mechanisms.
SN  - 0263-6352
AD  - Laboratory of Behavioral Sciences, National Institute on Aging, Baltimore, Maryland, USA.
U2  - PMID: 8986906.
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ER  - 

TY  - NEWS
AU  - Kraemer, Kenneth H.
T1  - Xeroderma Pigmentosum Knockout Mice: An Immunologic Tale.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/09//
VL  - 107
IS  - 3
M3  - Editorial
SP  - 291
EP  - 292
SN  - 0022202X
AB  - The article focuses on a novel system called xeroderma pigmentosum (XP) knockout mice, permitting the examination of the interaction of ultraviolet (UV) and DNA repair on immune function in an intact animal. Patients with XP have more than a 1000-fold increased risk of developing cancer on sun-exposed skin. This recessive disorder has clinical sun sensitivity that is associated with increased sensitivity to killing of cultured skin cells after exposure to UV. Researcher James Cleaver showed that XP cells have impaired ability to remove DNA photoproducts produced by UV exposure. Subsequent studies have demonstrated that seven different molecular defects may result in clinical XP.
KW  - XERODERMA pigmentosum
KW  - ULTRAVIOLET radiation
KW  - DNA
KW  - IMMUNE system
KW  - PHOTOSENSITIVITY disorders
KW  - PRECANCEROUS conditions
KW  - SKIN abnormalities
N1  - Accession Number: 12362992; Kraemer, Kenneth H. 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, U.S.A..; Source Info: Sep96, Vol. 107 Issue 3, p291; Subject Term: XERODERMA pigmentosum; Subject Term: ULTRAVIOLET radiation; Subject Term: DNA; Subject Term: IMMUNE system; Subject Term: PHOTOSENSITIVITY disorders; Subject Term: PRECANCEROUS conditions; Subject Term: SKIN abnormalities; Number of Pages: 2p; Document Type: Editorial
L3  - 10.1111/1523-1747.ep12362992
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DB  - aph
ER  - 

TY  - JOUR
AU  - Jun-Mo Yang
AU  - Kiebang Nam
AU  - Ki-Beom Park
AU  - Won-Serk Kim
AU  - Kee-Chan Moon
AU  - Koh, Jai K.
AU  - Steinert, Peter M.
AU  - Eil-Soo Lee
T1  - A Novel H1 Mutation in the Keratin 1 Chain in Epidermolytic Hyperkeratosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/09//
VL  - 107
IS  - 3
M3  - Article
SP  - 439
EP  - 441
SN  - 0022202X
AB  - We report a novel mutation in a case of epidermolytic hyperkeratosis that results in a proline for arginine substitution in the penultimate residue position of the H1 subdomain of the keratin 1 chain, which is sear the beginning of the rod domain. This causes a severe clinical disease classified as PS-2. Therefore, the H1 subdomain is probably equally important for the maintenance of keratin intermediate filament integrity as the rod domain. Since earlier concepts had implied that mutations in the H1 subdomain produce milder disease, this case suggests that attempts to correlate mutations with disease presentation remain problematic. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KERATIN
KW  - ICHTHYOSIS
KW  - MUTATION (Biology)
KW  - KERATOSIS
KW  - CYTOPLASMIC filaments
KW  - ARGININE
KW  - PROLINE
KW  - <em>H1 subdomain</em>
KW  - <em>ichthyosis</em>
KW  - <em>type II keratin</em>
N1  - Accession Number: 12365483; Jun-Mo Yang 1 Kiebang Nam Ki-Beom Park Won-Serk Kim 1 Kee-Chan Moon 2 Koh, Jai K. 2 Steinert, Peter M. 3 Eil-Soo Lee; Affiliation:  1: Department of Dermatology, Samsung Medical Center, Republic of Korea.  2: Department of Dermatology, Asan Medical Center, Seoul, Republic of Korea.  3: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, Maryland, U.S.A..; Source Info: Sep96, Vol. 107 Issue 3, p439; Subject Term: KERATIN; Subject Term: ICHTHYOSIS; Subject Term: MUTATION (Biology); Subject Term: KERATOSIS; Subject Term: CYTOPLASMIC filaments; Subject Term: ARGININE; Subject Term: PROLINE; Author-Supplied Keyword: <em>H1 subdomain</em>; Author-Supplied Keyword: <em>ichthyosis</em>; Author-Supplied Keyword: <em>type II keratin</em>; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12365483
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DB  - aph
ER  - 

TY  - JOUR
AU  - Kawakami, Norito
AU  - Iwata, Noboru
AU  - Tanigawa, Takeshi
AU  - Oga, Hideshi
AU  - Araki, Shunichi
AU  - Fujihara, Shigeki
AU  - Kitamura, Toshinori
T1  - Prevalence of Mood and Anxiety Disorders in a Working Population in Japan.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1996/09//
M3  - Article
SP  - 899
EP  - 905
SN  - 00961736
AB  - To learn the prevalence of mood and anxiety disorders (as defined by the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised) in a working population in Japan, we analyzed data from a population-based survey. Among 140 respondents who had a job, 8% experienced any of seven mood and anxiety disorders in the past 6 months and 19% had in their lifetime. The 6-month and lifetime prevalence rates of major depressive episodes were 4% and 14%, respectively. The 6-month and lifetime prevalence rates of phobic disorders were both 4%. The lifetime prevalence rates for other anxiety disorders were 1% or less. The 6-month rate of any disorder, as well as 6-month and lifetime rates of phobic disorders, was higher in white-collar employees than in self-employed workers (P < 0.05). The multiple logistic regression confirmed the tendency after controlling for sex and age, although the result was not significant (P > 0.05). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 113379523; Kawakami, Norito 1 Iwata, Noboru 1 Tanigawa, Takeshi 1 Oga, Hideshi 1 Araki, Shunichi 1 Fujihara, Shigeki 1 Kitamura, Toshinori 1; Affiliation:  1: From the Department of Public Health, Faculty of Medicine, University of Tokyo, Tokyo, Japan (Dr Kawakami, Dr Tanigawa, Mr Oga, Dr Araki); Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan (Dr Iwata); Yamanashi Prefecture Mental Health and Welfare Center, Yamanashi, Japan (Dr Fujihara); and Department of Sociocultural Environmental Research, National Institute of Mental Health, Japan (Dr Kitamura).; Source Info: Sep1996, p899; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4012
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TY  - JOUR
ID  - 107337507
T1  - Dental caries, restoration and tooth conditions in US adults, 1988-1991... selected findings from the Third National Health and Nutrition Examination Survey.
AU  - Brown LJ
AU  - Winn DM
AU  - White BA
Y1  - 1996/09//
N1  - Accession Number: 107337507. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Dental Caries -- Epidemiology -- United States
KW  - Tooth Diseases -- Epidemiology -- United States
KW  - Crowns -- Evaluation
KW  - Dentures -- Evaluation
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Male
KW  - Sex Factors
KW  - Race Factors
KW  - Ethnic Groups
KW  - Hispanics
KW  - Age Factors
KW  - Epidemiological Research
KW  - Interrater Reliability
KW  - Surveys
KW  - Probability Sample
KW  - Clinical Assessment Tools
KW  - Data Analysis Software
KW  - Descriptive Statistics
KW  - Control (Research)
KW  - Prevalence
KW  - Summated Rating Scaling
KW  - Prospective Studies
KW  - P-Value
KW  - United States
KW  - Human
SP  - 1315
EP  - 1325
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 127
IS  - 9
CY  - Chicago, Illinois
PB  - American Dental Association
AB  - This article provides estimates of dental caries experience and selected restorative and tooth conditions among U.S. adults, obtained from Phase 1 (1988-1991) of the Third National Health and Nutrition Examination Survey. Between 1988 and 1991, 94 percent of adults in the United States showed evidence of past or present coronal caries. Based on the data collected, the authors estimate that about 40.5 percent, or 61.6 million, dentate adults had at least one tooth or tooth space that could potentially benefit from professional treatment. Minimally, it is estimated that 135.6 million tooth or tooth spaces among U.S. adults may benefit from professional treatment. These estimates supplement information available from the DMF index to provide a broader profile of the impact of dental caries on permanent tooth of U.S. adults.
SN  - 0002-8177
AD  - Division of Epidemiology and Oral Disease Prevention, National Institute of Dental Research, National Institutes of Health, US Public Health Service, Bethesda, MD
U2  - PMID: 8854607.
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DB  - rzh
ER  - 

TY  - JOUR
AU  - Ravussin, Eric
AU  - Tataranni, Pietro Antonio
T1  - The role of altered sympathetic nervous system activity in the pathogenesis of obesity.
JO  - Proceedings of the Nutrition Society
JF  - Proceedings of the Nutrition Society
Y1  - 1996/09//
VL  - 55
IS  - 3
M3  - Article
SP  - 793
EP  - 802
SN  - 00296651
N1  - Accession Number: 56765547; Ravussin, Eric 1; Tataranni, Pietro Antonio 1; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Rm 541, Phoenix, Arizona 85016, USA; Issue Info: Sep1996, Vol. 55 Issue 3, p793; Number of Pages: 10p; Document Type: Article
L3  - 10.1079/PNS19960079
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ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - Divergent Realities: The Emotional Lives of Mothers, Fathers and Adolescents (Book).
JO  - Social Service Review
JF  - Social Service Review
Y1  - 1996/09//
VL  - 70
IS  - 3
M3  - Book Review
SP  - 489
EP  - 490
SN  - 00377961
AB  - Reviews the book "Divergent Realities: The Emotional Lives of Mothers, Fathers and Adolescents," by Reed Larson.
KW  - HOMEMAKERS
KW  - NONFICTION
KW  - LARSON, Reed
KW  - DIVERGENT Realities: The Emotional Lives of Mothers, Fathers & Adolescents (Book)
N1  - Accession Number: 9702061264; Lamb, Michael E. 1; Affiliation:  1: National Institute of Child Health and Human Development.; Source Info: Sep96, Vol. 70 Issue 3, p489; Subject Term: HOMEMAKERS; Subject Term: NONFICTION; Reviews & Products: DIVERGENT Realities: The Emotional Lives of Mothers, Fathers & Adolescents (Book); People: LARSON, Reed; Number of Pages: 2p; Document Type: Book Review
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107312197
T1  - Short-term predictors of incident stroke in older adults. The Cardiovascular Health Study.
AU  - Manolio TA
AU  - Kronmal RA
AU  - Burke GL
AU  - O'Leary DH
AU  - Price TR
AU  - Manolio, T A
AU  - Kronmal, R A
AU  - Burke, G L
AU  - O'Leary, D H
AU  - Price, T R
Y1  - 1996/09//1996 Sep
N1  - Accession Number: 107312197. Language: English. Entry Date: 19970201. Revision Date: 20161126. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: This study was supported by contracts N01-HC-85079 through N01-HC-85086 from the National Heart, Lung, and Blood Institute. NLM UID: 0235266. 
KW  - Stroke -- Epidemiology
KW  - Age Factors
KW  - Risk Factors
KW  - Cardiovascular Risk Factors
KW  - Sex Factors
KW  - Time Factors
KW  - Incidence
KW  - Funding Source
KW  - Prospective Studies
KW  - Interviews
KW  - Record Review
KW  - Chi Square Test
KW  - T-Tests
KW  - Cox Proportional Hazards Model
KW  - Step-Wise Multiple Regression
KW  - Multivariate Analysis
KW  - Data Analysis Software
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 1479
EP  - 1486
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 27
IS  - 9
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Background and Purpose: Risk factors for incident stroke have been examined in middle-aged persons, but less is known about stroke precursors in the elderly, who suffer the highest rates of stroke. Short-term risk factors for incident stroke were examined in a longitudinal, population-based study including extensive measures of subclinical disease.Methods: Prospective study of 5201 women and men aged 65 years and older was undertaken in the multicenter Cardiovascular Health Study.Results: During an average 3.31-year follow-up, 188 incident strokes occurred. Stroke incidence increased significantly with age and was similar in women and men. Factors associated with increased stroke risk in multivariate analysis included age, aspirin use, diabetes, impaired glucose tolerance, higher systolic blood pressure, increased time needed to walk 15 ft. frequent falls, elevated creatinine level, abnormal left ventricular (LV) wall motion and increased LV mass on echocardiography, ultrasound-defined carotid stenosis, and atrial fibrillation. Increased LV mass and carotid stenosis were associated with twofold and threefold increases in incidences of stroke, respectively (P < .001). Aspirin users had a 52% higher risk of stroke (relative risk, 1.52; 95% confidence interval, 1.1 to 2.0; P < .007) after adjustment for other factors. This association was present only among aspirin users without prior coronary disease, atrial fibrillation, claudication, or transient ischemic attack, who had an 84% higher risk (relative risk, 1.84; 95% confidence interval, 1.2 to 2.8).Conclusions: Short-term risk of stroke has a complex relationship with aspirin use and is strongly related to subclinical disease in this sample of older adults. These relationships should be considered in assessing stroke risk in the elderly, in whom recognized and subclinical cardiovascular disease is highly prevalent.
SN  - 0039-2499
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md 20892-7934, USA
AD  - National Heart, Lung, and Blood Institute, 6701 Rockledge Dr, Rm 8160, Bethesda, MD 20892-7934
U2  - PMID: 8784116.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107312197&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00486-003
AN  - 2006-00486-003
AU  - Rajapakse, Jagath C.
AU  - Giedd, Jay N.
AU  - Rumsey, Judith M.
AU  - Vaituzis, A. Catherine
AU  - Hamburger, Susan D.
AU  - Rapoport, Judith L.
T1  - Regional MRI measurements of the corpus callosum: A methodological and developmental study.
JF  - Brain & Development
JO  - Brain & Development
JA  - Brain Dev
Y1  - 1996/09//Sep-Oct, 1996
VL  - 18
IS  - 5
SP  - 379
EP  - 388
CY  - Netherlands
PB  - Elsevier Science
SN  - 0387-7604
SN  - 1872-7131
AD  - Rajapakse, Jagath C., Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 6N240, 10 Center Drive, MSC 1600, Bethesda, MD, US, 20892-1600
N1  - Accession Number: 2006-00486-003. PMID: 8891233 Partial author list: First Author & Affiliation: Rajapakse, Jagath C.; Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20060417. Correction Date: 20160509. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Corpus Callosum; Magnetic Resonance Imaging. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Physical and Neurological Examination for Subtle Signs. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep-Oct, 1996. 
AB  - A technique for quantifying the midsagittal size and shape of the corpus callosum (CC) from magnetic resonance brain scans is presented. The technique utilizes the distances to the ventral and dorsal boundaries of small sectors of the CC from a reference point to c0mpute the size and shape parameters of the CC and its subdivisions. Intrarater and interrater interclass correlation coefficients for the area measurements ranged from 0.88 to 0.99. Correlations between these automated measures and those obtained by pixel counting were equally high. The corpus callosa of 104 (57 male and 47 female) right-handed healthy children and adolescents, ages 4-18, were examined in relation to age and sex. Corpus callosum growth was most striking for the splenium and isthmus with some changes in the midbody regions. The area and perimeter of these regions increased, shapes became more compact, and the boundaries became more regular with age. The length and curvature at the anterior and posterior regions of the CC increased more rapidly in males than in females. These significant and consistent results indicate that the method is reliable and sensitive to developmental changes of the CC. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - corpus callosum
KW  - magnetic resonance brain scans
KW  - splenium
KW  - isthmus
KW  - 1996
KW  - Brain
KW  - Corpus Callosum
KW  - Magnetic Resonance Imaging
KW  - 1996
DO  - 10.1016/0387-7604(96)00034-4
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UR  - jcr@helix.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17623-028
AN  - 2004-17623-028
AU  - Lamb, Michael E.
T1  - Fathering in America: New Challenges and Champions.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1996/09//
VL  - 41
IS  - 9
SP  - 911
EP  - 911
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17623-028. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Family Relations; Father Absence; Father Child Relations; Fathers; Trends. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30). Reviewed Item: Marsiglio, William (Ed). Fatherhood: Contemporary Theory, Research, and Social Policy=Thousand Oaks, CA: Sage, 1995. 320 pp; 1995. Page Count: 1. Issue Publication Date: Sep, 1996. 
AB  - The reviewer notes that interest in fatherhood, father-child relationships, and paternal influences has increased dramatically in the last few years, following a period of relative quiescence and inattention in the 1980s. Since 1990, politicians and opinion leaders have underscored the personal, social, and economic costs of fatherlessness, and popular movements with secular, religious, conservative, liberal, and eclectic agendas have all emphasized the desirability of having fathers invest psychologically in their children as well as in their children's welfare. Marsiglio's collection of essays (see record [rid]1995-98085-000[/rid]) captures and represents these trends well. All provide thoughtful analyses of recent theory and research, and although most of the contributors are sociologists by training, the majority appear aware of major trends in the psychological literature and make efforts to bridge the conceptual gaps between psychology and sociology as well as those between survey research and the more intensive study of family processes and circumstances. Readers interested in an accessible survey of recent trends would benefit greatly from the volume, rewarded by many ideas for future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - father-child relationships
KW  - fatherhood
KW  - paternal influences
KW  - fatherlessness
KW  - fathers
KW  - trends
KW  - 1996
KW  - Family Relations
KW  - Father Absence
KW  - Father Child Relations
KW  - Fathers
KW  - Trends
KW  - 1996
U2  - Marsiglio, William (Ed). (1995); Fatherhood: Contemporary Theory, Research, and Social Policy; Thousand Oaks, CA: Sage, 1995. 320 pp; 0-8039-5782-3 (Hardcover); 0-8039-5783-1 (Paperback).
DO  - 10.1037/003136
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17623-060
AN  - 2004-17623-060
AU  - Newlin, David B.
T1  - Review of Addictive Behaviour: Cue Exposure Theory and Practice.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1996/09//
VL  - 41
IS  - 9
SP  - 948
EP  - 949
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17623-060. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Newlin, David B.; National Institute on Drug Abuse, Baltimore, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Craving; Cues; Drug Abuse. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Drummond, D. Colin (Ed); Tiffany, Stephen T. (Ed); Glautier, Steven (Ed); Remington, Bob (Ed). Addictive Behaviour: Cue Exposure Theory and Practice=Chichester, England: Wiley, 1995. 248 pp; 1995. References Available: Y. Page Count: 2. Issue Publication Date: Sep, 1996. 
AB  - The reviewer notes that this is a very thorough, scholarly book (see record [rid]1995-97983-000[/rid]). It has 10 chapters, each of which is a review of the literature concerning different but overlapping aspects of cue exposure in substance abuse research. The reader is left with the distinct feeling that the theoretical models, experimental paradigms, and treatment regimens that have been applied to the problem of craving in substance abuse have all been inadequate to the task. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - substance abuse
KW  - cue exposure theory
KW  - cue exposure
KW  - craving
KW  - 1996
KW  - Craving
KW  - Cues
KW  - Drug Abuse
KW  - 1996
U2  - Drummond, D. Colin (Ed); Tiffany, Stephen T. (Ed); Glautier, Steven (Ed); Remington, Bob (Ed). (1995); Addictive Behaviour: Cue Exposure Theory and Practice; Chichester, England: Wiley, 1995. 248 pp; 0-471-94454-8.
DO  - 10.1037/003168
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17623-060&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13554-007
AN  - 2008-13554-007
AU  - Melzer, Peter
AU  - Smith, Carolyn B.
T1  - Plasticity of metabolic whisker maps in somatosensory brainstem and thalamus of mice with neonatal lesions of whisker follicles.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1996/09//
VL  - 8
IS  - 9
SP  - 1853
EP  - 1864
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Smith, Carolyn B., Laboratory of Cerebral Metabolism, National Institute of Mental Health, Building 36, Room 1A05, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13554-007. PMID: 8921276 Partial author list: First Author & Affiliation: Melzer, Peter; Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20100927. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Melzer, Peter. Major Descriptor: Somatosensory Cortex; Stereotaxic Atlas; Thalamus; Brain Lesions (Experimental). Minor Descriptor: Mice; Neonatal Development; Roentgenography. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Brain Imaging; Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Sep, 1996. Publication History: Accepted Date: Apr 2, 1996; Revised Date: Mar 26, 1996; First Submitted Date: Sep 18, 1995. Copyright Statement: European Neuroscience Association
AB  - We employed the autoradiographic deoxyglucose method to study metabolic whisker maps of the adult mouse somatosensory brainstem and thalamus after the neonatal removal of left whisker follicles C1, C2 and C3. Left whiskers B1-3 and D1-3 were deflected to metabolically activate the somatosensory pathway. Unoperated mice that were stimulated in the same fashion served as controls. Whisker stimulation resulted in an ipsilateral increase in metabolic activity in the three trigeminal brainstem structures in which the whiskers are represented topologically by segments of high cytochrome oxidase activity, i.e. subnucleus caudalis, subnucleus interpolaris and nucleus principalis. In the two subnuclei of mice with lesions and of controls, there was an increase in metabolic activity of the representations of the deflected whiskers, whereas the metabolic activity of representations A1-3 and E1-3 was low. Apart from these similarities, the metabolic activation of the representations originally representing whiskers C1-3 was remarkably greater in mice with lesions than in controls. This increase reached statistical significance in subnucleus caudalis and approached statistical significance in subnucleus interpolaris. In nucleus principalis the deprived territory was only partially activated and the degree of metabolic activation was less than in the subnuclei. In the thalamic ventrobasal complex of mice with lesions metabolic activity was unpatterned whereas two areas of metabolic activation were distinct in controls. Hence, the removal of whisker follicles in newborn mice resulted in the suppression of localized metabolic responses to whisker stimulation in the thalamus, whereas in the brainstem stimulus-related activity was prominent and the deprived territory became responsive to the stimulation of whisker follicles adjacent to the lesion. Apparently, the modification of the whisker representation at the first synapse of the pathway induces a diminution of localized responsivity in the thalamus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - metabolic whisker maps
KW  - somatosensory brainstem
KW  - thalamus
KW  - mice
KW  - neonatal lesions
KW  - whisker follicles
KW  - autoradiography
KW  - 1996
KW  - Somatosensory Cortex
KW  - Stereotaxic Atlas
KW  - Thalamus
KW  - Brain Lesions (Experimental)
KW  - Mice
KW  - Neonatal Development
KW  - Roentgenography
KW  - 1996
U1  - Sponsor: Sponsor name not included. Other Details: Fogarty Fellowship. Recipients: Melzer, Peter
DO  - 10.1111/j.1460-9568.1996.tb01329.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38427-006
AN  - 2015-38427-006
AU  - Maccaferri, Gianmaria
AU  - McBain, Chris J.
T1  - Long-term potentiation in distinct subtypes of hippocampal nonpyramidal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/09//
VL  - 16
IS  - 17
SP  - 5334
EP  - 5343
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - McBain, Chris J., Unit on Cellular and Synaptic Physiology, Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, Room 5A72, Building 49, 9000 Rockville Pike, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-38427-006. PMID: 8757246 Partial author list: First Author & Affiliation: Maccaferri, Gianmaria; National Institute of Child Health and Human Development, Laboratory of Cellular and Molecular Neurophysiology, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hippocampus; N-Methyl-D-Aspartate; Interneurons; Long-term Potentiation. Minor Descriptor: Pyramidal Neurons; Synaptic Plasticity. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Sep, 1996. Publication History: Accepted Date: Jun 6, 1996; Revised Date: Jun 4, 1996; First Submitted Date: Apr 30, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - We have investigated NMDA receptor-dependent long-term potentiation (LTP) in distinct subtypes of nonpyramidal neurons of the CA1 hippocampus using induction protocols that permitted the differentiation between a direct form of LTP and plasticity resulting simply from the 'passive propagation' of LTP occurring on CA1 pyramidal neurons. Two types of stratum (st.) oriens/alveus interneurons received passive propagation of synaptic potentiation via the recurrent collaterals of CA1 pyramidal cells, but neither subtype possessed direct plasticity. In st. radiatum, two distinct classes of cells were observed: st. radiatum interneurons that showed neither direct nor propagated forms of synaptic plasticity, and 'giant cells' for which EPSPs were robustly potentiated after a pairing protocol. This potentiation is similar to the LTP described in pyramidal cells, and its induction requires NMDA receptor activation. Thus, a large heterogeneity of synaptic plasticity exists in morphologically distinct neurons and suggests that complex changes in the CA1 network properties will occur after the induction of LTP. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hippocampus
KW  - interneurons
KW  - LTP
KW  - plasticity
KW  - GABAergic
KW  - CA1
KW  - 1996
KW  - Hippocampus
KW  - N-Methyl-D-Aspartate
KW  - Interneurons
KW  - Long-term Potentiation
KW  - Pyramidal Neurons
KW  - Synaptic Plasticity
KW  - 1996
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38428-021
AN  - 2015-38428-021
AU  - Levine, Michael S.
AU  - Altemus, Katharine L.
AU  - Cepeda, Carlos
AU  - Cromwell, Howard C.
AU  - Crawford, Cynthia
AU  - Ariano, Marjorie A.
AU  - Drago, John
AU  - Sibley, David R.
AU  - Westphal, Heiner
T1  - Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/09//
VL  - 16
IS  - 18
SP  - 5870
EP  - 5882
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Levine, Michael S., Mental Retardation Research Center, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, US, 90024-1759
N1  - Accession Number: 2015-38428-021. PMID: 8795639 Partial author list: First Author & Affiliation: Levine, Michael S.; Mental Retardation Research Center, University of California, Los Angeles, Los Angeles, CA, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Levine, Michael S. Major Descriptor: Dopamine; Mediated Responses; Mutations; N-Methyl-D-Aspartate; Neural Receptors. Minor Descriptor: Mice. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 13. Issue Publication Date: Sep, 1996. Publication History: Accepted Date: Jun 25, 1996; Revised Date: Jun 24, 1996; First Submitted Date: May 6, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - The role of D₁ dopamine (DA) receptors in mediating the ability of DA to modulate responses attributable to activation of NMDA receptors was examined in mice lacking D1A dopamine receptors. Specifically, experiments were designed to test the hypothesis that the ability of DA to potentiate responses mediated by activation of NMDA receptors was attributable to activation of D₁ receptors. Based on this hypothesis, we would predict that in the D1A mutant mouse, either DA would not induce enhancement of NMDA-mediated responses, or the enhancement would be severely attenuated. The results provided evidence to support the hypothesis. In mutant mice, DA and D₁ receptor agonists did not potentiate responses mediated by activation of NMDA receptors. In contrast, in control mice, both DA and D₁ receptor agonists markedly potentiated responses mediated by activation of NMDA receptors. The effects of DA in attenuating responses mediated by activation of non-NMDA receptors also were altered in the mutant, suggesting that this action of DA may require coupling or interactions between D₁ and D₂ receptors. The present studies also provided an opportunity to assess some of the basic electrophysiological and morphological properties of neostriatal neurons in mice lacking D1A DA receptors. Resting membrane potential, action potential parameters, input resistance, excitability, somatic size, dendritic extent, and estimates of spine density in mutants and controls were similar, suggesting that these basic neurophysiological and structural properties have not been changed by the loss of the D1A DA receptor. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dopamine receptors
KW  - D1
KW  - excitatory amino acid receptors
KW  - knock-out mice
KW  - mutant
KW  - neostriatal slices
KW  - NMDA
KW  - 1996
KW  - Dopamine
KW  - Mediated Responses
KW  - Mutations
KW  - N-Methyl-D-Aspartate
KW  - Neural Receptors
KW  - Mice
KW  - 1996
U1  - Sponsor: US Public Health Service, US. Grant: NS 35233; AG 10252; HD05958. Recipients: Levine, Michael S.
U1  - Sponsor: US Public Health Service, US. Grant: NS 33277. Recipients: Ariano, Marjorie A.
U1  - Sponsor: Royal Australasian College of Physicians. Other Details: Basser Travelling Fellowship. Recipients: Drago, John
U1  - Sponsor: National Health and Medical Research Council, Australia. Recipients: Drago, John
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - NEWS
AU  - Gergen, Peter
T1  - Editorial: Social Class and Asthma--Distinguishing between the Disease and the Diagnosis.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/10//
VL  - 86
IS  - 10
M3  - Editorial
SP  - 1361
EP  - 1362
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses a number of studies which show that active asthma was more common among African-American children than among White children. The studies found the frequency of the diagnosis of asthma increased with decreasing family income. The author believes that the absence of an excess of diagnosed asthma among the lower social classes in Canada and Great Britain and its presence in urban U.S. possibly could be a reflection of differences in health care systems. These studies highlighted the fact that social position affects the acquisition of an asthma diagnosis.
KW  - ASTHMA -- Diagnosis
KW  - ASTHMA in children
KW  - AFRICAN American children
KW  - WHITE children
KW  - RACIAL differences
KW  - SOCIAL factors
KW  - INCOME
KW  - SOCIAL classes
N1  - Accession Number: 20707514; Gergen, Peter 1; Affiliation:  1: National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Md; Source Info: Oct96, Vol. 86 Issue 10, p1361; Subject Term: ASTHMA -- Diagnosis; Subject Term: ASTHMA in children; Subject Term: AFRICAN American children; Subject Term: WHITE children; Subject Term: RACIAL differences; Subject Term: SOCIAL factors; Subject Term: INCOME; Subject Term: SOCIAL classes; Number of Pages: 2p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Grant, Bridget F.
AU  - Dawson, Deborah A.
T1  - Alcohol and Drug Use, Abuse, and Dependence among Welfare Recipients.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1996/10//
VL  - 86
IS  - 10
M3  - Article
SP  - 1450
EP  - 1454
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This paper presents national estimates of heavy drinking, drug use, and alcohol and drug abuse and/or dependence among recipients of selected welfare programs. Methods. Data from the 1992 National Longitudinal Alcohol Epidemiologic Survey were analyzed. Results. The percentages of welfare recipients using, abusing, or dependent on alcohol or drugs were relatively small and consistent with the general US population and those not receiving welfare benefits. Conclusions. Although a minority of welfare recipients have alcohol or drug problems, substance abuse prevention and treatment services are needed among high-risk sub-groups. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse
KW  - ALCOHOLISM
KW  - WELFARE recipients
KW  - HEALTH surveys -- United States
KW  - UNITED States
N1  - Accession Number: 9611210103; Grant, Bridget F. 1 Dawson, Deborah A. 1; Affiliation:  1: Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.; Source Info: Oct96, Vol. 86 Issue 10, p1450; Subject Term: DRUG abuse; Subject Term: ALCOHOLISM; Subject Term: WELFARE recipients; Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 2962
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107353013
T1  - Editorial: social class and asthma -- distinguishing between the disease and the diagnosis.
AU  - Gergen P
Y1  - 1996/10//
N1  - Accession Number: 107353013. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074. 
KW  - Asthma
KW  - Social Class
KW  - Asthma -- Diagnosis
KW  - Prevalence
KW  - Blacks
KW  - Whites
KW  - Respiratory Sounds -- Etiology
KW  - United States
KW  - Canada
KW  - Great Britain
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
SP  - 1361
EP  - 1362
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 86
IS  - 10
CY  - Washington, District of Columbia
PB  - American Public Health Association
SN  - 0090-0036
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
U2  - PMID: 8876501.
DO  - 10.2105/AJPH.86.10.1361
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107353054
T1  - Alcohol and drug use, abuse, and dependence among welfare recipients.
AU  - Grant BF
AU  - Dawson DA
Y1  - 1996/10//
N1  - Accession Number: 107353054. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074. 
KW  - Alcoholism -- Epidemiology
KW  - Substance Abuse -- Epidemiology
KW  - Substance Dependence -- Epidemiology
KW  - Social Welfare
KW  - United States
KW  - Age Factors
KW  - Sex Factors
KW  - Prevalence
KW  - Surveys
KW  - Interviews
KW  - Multi-Stage Cluster
KW  - T-Tests
KW  - Data Analysis Software
KW  - Kappa Statistic
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 1450
EP  - 1454
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 86
IS  - 10
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This paper presents national estimates of heavy drinking, drug use, and alcohol and drug abuse and/or dependence among recipients of selected welfare programs. METHODS: Data from the 1992 National Longitudinal Alcohol Epidemiologic Survey were analyzed. RESULTS: The percentages of welfare recipients using, abusing, or dependent on alcohol or drugs were relatively small and consistent with the general US population and those not receiving welfare benefits. CONCLUSIONS: Although a minority of welfare recipients have alcohol or drug problems, substance abuse prevention and treatment services are needed among high-risk subgroups.
SN  - 0090-0036
AD  - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Suite 514, 6000 Executive Blvd, MSC 7003, Bethesda, MD 20892-7003
U2  - PMID: 8876518.
DO  - 10.2105/AJPH.86.10.1450
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107158882
T1  - Relation between sodium balance and menstrual cycle symptoms in normal women.
AU  - Olson BR
AU  - Forman MR
AU  - Lanza E
AU  - McAdam PA
AU  - Beecher G
AU  - Kimzey LM
AU  - Campbell WS
AU  - Raymond EG
AU  - Brentzel SL
AU  - Guttsches-Ebeling B
Y1  - 1996/10//10/01/96
N1  - Accession Number: 107158882. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by intramural funds from the National Institute of Child Health and Human Development and the National Cancer Institute of the National Institute of Health. NLM UID: 0372351. 
KW  - Menstrual Cycle -- Drug Effects
KW  - Sodium -- Pharmacodynamics
KW  - Perimenopausal Symptoms -- Complications
KW  - Prospective Studies
KW  - Diet Records
KW  - Sodium -- Blood
KW  - Sodium -- Urine
KW  - Funding Source
KW  - Diet, Sodium-Restricted
KW  - Questionnaires
KW  - T-Tests
KW  - Confidence Intervals
KW  - Adult
KW  - Female
KW  - Human
SP  - 564
EP  - 567
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 125
IS  - 7
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 0003-4819
AD  - National Institutes of Health, Bethesda, MD
U2  - PMID: 8815755.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107344366
T1  - Patient pointers from Innovations in Breast Cancer Care. The development of promising new cancer treatments.
AU  - Summers B
Y1  - 1996/10//1996 Oct
N1  - Accession Number: 107344366. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article; CEU; consumer/patient teaching materials; exam questions. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9889728. 
KW  - Oncologic Care
KW  - Antineoplastic Agents
KW  - Drug Approval
KW  - Neoplasms -- Drug Therapy
KW  - Education, Continuing (Credit)
KW  - Patient Education
KW  - Clinical Trials
KW  - Breast Neoplasms -- Drug Therapy
SP  - 7
EP  - 18
JO  - Innovations in Breast Cancer Care
JF  - Innovations in Breast Cancer Care
JA  - INNOV BREAST CANCER CARE
VL  - 2
IS  - 1
PB  - Meniscus Educational Institute
SN  - 1082-1341
AD  - Medicine Branch, National Cancer Institute Clinical Center, National Institutes of Health, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Moriwaki, Shin-Ichi
AU  - Stafanim, Miria
AU  - Lehmann, Alan R.
AU  - Hoeijmakers, Jan H.J.
AU  - Robbins, Jay H.
AU  - Rapin, Isablle
AU  - Botta, Elena
AU  - Tanganelli, Bianca
AU  - Vermeulen, Wim
AU  - Broughton, Benard C.
AU  - Kraemer, Kenneth H.
T1  - DNA Repair and Ultraviolet Mutagenesis in Cells From a New Patient With Xeroderma Pigmentosum Group G and Cockayne Syndrome Resemble Xeroderma Pigmentosum Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/10//
VL  - 107
IS  - 4
M3  - Article
SP  - 647
EP  - 653
SN  - 0022202X
AB  - Xeroderma pigmentosum (XP)/Cockayne syndrome (CS) complex is a combination of clinical features of two rare genetic disorders in one individual. A sun-sensitive boy (XP20BE) who had severe symptoms of CS, with dwarfism, microcephaly, retinal degeneration, and mental impairment, had XP-type pigmentation and died at 6 y with marked cachexia (weight 14.5 lb) without skin cancers. We evaluate his cultures cells for characteristics CS or XP DNA-repair abnormalities. The level of ultraviolet (UV)-induced unscheduled DNA synthesis was less than 5% of normal, characteristic of the excision-repair defect of XP. Cell fusion studies indicated that his cells were in XP complementation group G. His cells were hypersensitive to killing by UV, and their post-UV recovery of RNA synthesis was abnormally low, features of both CS and XP. Post-UV survival of plasmid pSP189 in his cells was markedly reduced, and post-UV plasmid mutation frequency was higher than with normal cells, as in both CS and XP. Sequence analysis of the mutated plasmid marker gene showed normal frequency of plasmids with multiple base substitutions, as in CS, and an abnormally increased frequency of G:C ↠ A:T mutations, a feature of XP. Transfection of UV-treated o/RSV cat with or without photoreactivation revealed that his cells, like XP cells, could not repair either cyclobutane pyrimidine dimers or non-dimer photoproducts. These results indicate that the DNA-repair features of the XP20BE (XP-G/CS) cells are phenotypically more like XP than CS cells, whereas clinically the CS phenotype is more prominent that XP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENETIC disorders
KW  - SYNDROMES
KW  - CULTURES (Biology)
KW  - CELLS
KW  - DNA
KW  - MUTATION (Biology)
KW  - <em>cancer</em>
KW  - <em>photoproducts</em>.
KW  - <em>shuttle vector plasmid</em>
KW  - <em>skin</em>
KW  - <em>transfection</em>
N1  - Accession Number: 12584287; Moriwaki, Shin-Ichi 1 Stafanim, Miria 2 Lehmann, Alan R. 3 Hoeijmakers, Jan H.J. 4 Robbins, Jay H. 5 Rapin, Isablle 6 Botta, Elena 2 Tanganelli, Bianca 2 Vermeulen, Wim 4 Broughton, Benard C. 3 Kraemer, Kenneth H. 1; Affiliation:  1: Laboratory of Molecular Carcinogenesis, Maryland, U.S.A  2: Istituto di Genetica Biochimicated Evoluzionistica, Consiglio Nazionale delle Ricerche, Pavia Italy  3: MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, England  4: Department of Cell Biology and Genetics, Medical Genetic Center, Erasmus University, Rotterdam, The Netherlands  5: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A  6: Department of Neurology, Albert Einstein College of Medicine, Bronx New York, U.S.A.; Source Info: Oct96, Vol. 107 Issue 4, p647; Subject Term: GENETIC disorders; Subject Term: SYNDROMES; Subject Term: CULTURES (Biology); Subject Term: CELLS; Subject Term: DNA; Subject Term: MUTATION (Biology); Author-Supplied Keyword: <em>cancer</em>; Author-Supplied Keyword: <em>photoproducts</em>.; Author-Supplied Keyword: <em>shuttle vector plasmid</em>; Author-Supplied Keyword: <em>skin</em>; Author-Supplied Keyword: <em>transfection</em>; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12584287
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107276242
T1  - When to hospitalize for community-acquired pneumonia.
AU  - Moore TA
AU  - Tuazon CU
Y1  - 1996/10//1996 Oct
N1  - Accession Number: 107276242. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8006299. 
KW  - Community-Acquired Infections
KW  - Pneumonia
KW  - Pneumonia -- Diagnosis
KW  - Hospitalization
KW  - Pneumonia -- Radiography
KW  - Decision Making, Clinical
KW  - Pneumonia -- Microbiology
KW  - Pneumonia -- Drug Therapy
KW  - Outpatients
KW  - Inpatients
SP  - 878
EP  - 888
JO  - Journal of Respiratory Diseases
JF  - Journal of Respiratory Diseases
JA  - J RESPIR DIS
VL  - 17
IS  - 10
CY  - Framingham, Massachusetts
PB  - United Business Media
AB  - Diagnostic tests for patients with suspected community-acquired pneumonia include chest films, Gram's stain and culture of expectorated sputum, blood count, and chemistry profile. Consider hospitalization if the patient is older than 65 years, mental status is altered, vital sign abnormalities are present, a high-risk pathogen, is suspected, or there is underlying neoplastic disease. Base empiric therapy on the most likely pathogen; presence of coexisting disorders, such as chronic obstructive pulmonary disease; adequacy of the immune response; and patterns of antibiotic resistance in the community.
SN  - 0194-259X
AD  - Junior Staff Fellow, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Heinzen, R. A.
AU  - Howe, D.
AU  - Mallavia, L. P.
AU  - Rockery, D. D.
AU  - Hackstadt, T.
T1  - Developmentally regulated synthesis of an unusually small, basic peptide by Coxiella bumetll.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/10//
VL  - 22
IS  - 1
M3  - Article
SP  - 9
EP  - 19
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - <em>Coxiella burnetii</em> undergoes a poorly defined developmental cycle within phagolysosomes of eukaryotic host cells. Two distinct developmental forms are part of this cycle: a small-cell variant (SCV) and large-cell variant (LCV). Ultrastructurally, the SCV is distinguished from the LCV by its smaller size and condensed chromatin. At a molecular level, little is known about morphogenesis in <em>C. burnetii</em>, and no proteins specific to the SCV have been identified. Preparative isoelectric focusing was conducted to purify basic proteins possibly involved in SCV chromatin structure. A predominant protein of low <em>M</em>r was present in the most basic fraction, eluting with a pH of approx. 11. Degenerate deoxyoligonucleotides corresponding to the N-terminal sequence of this protein were used to recover a cosmid clone from a <em>C. burnetii</em> genomic library. Nucleotide sequencing of insert DNA revealed an open reading frame designated <em>scvA</em> (s̱mall-c̱ell-v̱ariant protein A̱) with coding potential for a 30 amino acid protein (ScvA) with a predicted <em>M</em>r of 3610. ScvA ls 46% arginine plus 46% glutamine with a predicted pl of 12.6. SDS-PAGE and silver staining of lysates of SCV and LCV purified by caesium chloride-equilibrium density centrifugation revealed a number of proteins unique to each cell type. Immunoblot analysis with ScvA antiserum demonstrated the presence of ScvA only in the SCV. By immunoelectron microscopy, ScvA antiserum labelled only the SCV, with the label concentrated on the condensed nucleoid. In addition, ScvA bound double-stranded DNA in gel mobility-shift assays. A 66% reduction in the mean number of gold particles per <em>Coxiella</em> cell was observed at 12 h post-Infection when compared with the starting inoculum. Collectively, these data suggest that synthesis of ScvA is developmentally regulated, and that the protein may serve a structural or functional role as an integral component of the SCV chromatin. Moreover, degradation of this protein may be a necessary prerequisite for morphogenesis from SCV to LCV. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Coxiella burnetii
KW  - Morphogenesis
KW  - Proteins
KW  - Deoxyribonucleotides
KW  - Nucleotide sequence
KW  - Chromatin
N1  - Accession Number: 21343692; Heinzen, R. A. 1; Email Address: robert_heinzen@nih.gov; Howe, D. 2; Mallavia, L. P. 2; Rockery, D. D. 1; Hackstadt, T. 1; Affiliations: 1: Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA; 2: Department of Microbiology, Washington State University, Pullman, Washington, USA; Issue Info: Oct1996, Vol. 22 Issue 1, p9; Thesaurus Term: Coxiella burnetii; Subject Term: Morphogenesis; Subject Term: Proteins; Subject Term: Deoxyribonucleotides; Subject Term: Nucleotide sequence; Subject Term: Chromatin; Number of Pages: 11p; Illustrations: 8 Diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107393393
T1  - The effects of heparin flush on patency of the GROSHONG catheter: a pilot study.
AU  - Mayo DJ
AU  - Horne MK III
AU  - Summers BL
AU  - Pearson DC
AU  - Helsabeck CB
Y1  - 1996/10//1996 Oct
N1  - Accession Number: 107393393. Language: English. Entry Date: 19961201. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Catheter-Related Thrombosis
KW  - Catheters, Vascular
KW  - Heparin -- Therapeutic Use
KW  - Vascular Access Devices
KW  - Catheter Care, Vascular
KW  - Pilot Studies
KW  - Prospective Studies
KW  - Retrospective Design
KW  - Record Review
KW  - Cancer Patients
KW  - Urokinase
KW  - Mann-Whitney U Test
KW  - Unpaired T-Tests
KW  - Fisher's Exact Test
KW  - Data Analysis Software
KW  - Normal Saline
KW  - Time Factors
KW  - Descriptive Statistics
KW  - Control Group
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1401
EP  - 1405
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 23
IS  - 9
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - Purpose/Objectives: To determine whether the addition of a heparinized saline flush would decrease clot formation and persistent withdrawal occlusion (PWO) in GROSHONG (Bard Access Systems, Salt Lake City, UT) catheters. Design: A prospective, nonrandomized study using a historical control group of patients with Groshong catheters that had been flushed weekly with 5 ml normal saline compared to data from patients with Groshong catheters flushed weekly with 2.5 ml heparinized saline (100 U/ml). A retrospective chart review was performed to determine the incidence of PWO. In both groups, the presence of liquid blood and adherent or nonsaherent clot in explanted catheters was recorded. Setting: Oncology inpatient and outpatient units of a cancer research center located in a mid-Atlantic city in the United States. Sample: Control group: Twenty-eight 9.5 Fr. double-lumen Groshong catheters maintained with a saline flush. Experimental group: Twenty-three double-lumen Groshong catheters maintained with a heparin flush. At the time of this report, 12 of these 23 catheters had been explanted and 11 remained in place. Methods: The frequency of PWO was measured in a retrospective chart review and determined by the number of urokinase instillations required for each catheter. All 28 catheters in the saline flush group and 8 catheters in the heparin flush group were examined immediately after removal for intraluminal liquid blood and adherent or nonadherent clot. Main Research Variables: Urokinase usage, intraluminal blood or clot, and PWO. Findings: PWO occurred less frequently in the heparin flush group (p = 0.006) than in the saline flush group. All 28 of the saline flush catheters developed an adherent clot in one or both lumens, whereas no adherent clots were found in the heparin flush catheters (p < 0.0001). Conclusions: The addition of a heparinized saline weekly flush to maintain Groshong catheters decreased the presence of intraluminal adherent clots and improved the catheter function. Implications for Nursing Practice: The safe delivery of medication and the ability to obtain blood specimens are vital for patients who depend on functioning venous access catheters. Flushing Groshong catheters with heparinized saline decreases the likelihood of intraluminal clot formation and catheter malfunction.
SN  - 0190-535X
AD  - Critical Care and Acute Patient Services, Warren Grant Magnuson Clinical Center of the National Institutes of Health, Bethesda, MD
U2  - PMID: 8899756.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106981148
T1  - Factors associated with disclosure of diagnosis to children with HIV/AIDS.
AU  - Wiener LS
AU  - Battles HB
AU  - Heilman N
AU  - Sigelman CK
AU  - Pizzo PA
Y1  - 1996/10//1996 Oct
N1  - Accession Number: 106981148. Language: English. Entry Date: 20021122. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Arizona Social Support Interview Schedule (ASSIS); Family Environment Scale (FES); Beck Depression Inventory (BDI). NLM UID: 9107942. 
KW  - Truth Disclosure
KW  - HIV Infections -- Diagnosis -- In Infancy and Childhood
KW  - Child Psychology
KW  - HIV Infections -- Psychosocial Factors -- In Infancy and Childhood
KW  - Decision Making
KW  - Parents -- Psychosocial Factors
KW  - Research Instruments
KW  - Psychological Tests
KW  - Semi-Structured Interview
KW  - Coefficient Alpha
KW  - One-Way Analysis of Variance
KW  - Chi Square Test
KW  - Data Analysis Software
KW  - Multiple Logistic Regression
KW  - Child
KW  - Female
KW  - Male
KW  - Human
SP  - 310
EP  - 324
JO  - Pediatric AIDS & HIV Infection
JF  - Pediatric AIDS & HIV Infection
JA  - PEDIATR AIDS HIV INFECT
VL  - 7
IS  - 5
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1045-5418
AD  - Pediatric Branch, National Cancer Institute, Bethesda, Maryland
U2  - PMID: 11361489.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107325242
T1  - Ethics in practice. Ethical dilemmas in dysphagia practice.
AU  - Sonies BC
Y1  - 1996///Fall1996
N1  - Accession Number: 107325242. Language: English. Entry Date: 19970601. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 9439750. 
KW  - Deglutition Disorders
KW  - Ethics
KW  - Decision Making, Ethical
SP  - 87
EP  - 93
JO  - Topics in Stroke Rehabilitation
JF  - Topics in Stroke Rehabilitation
JA  - TOP STROKE REHABIL
VL  - 3
IS  - 3
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
SN  - 1074-9357
AD  - WG Magnuson Clinical Center, Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00869-001
AN  - 2006-00869-001
AU  - Callahan, Phyllis
AU  - Baumann, Michael H.
AU  - Rabii, Jamshid
T1  - Inhibition of tuberoinfundibular dopaminergic neural activity during suckling: Involvement of μ and κ opiate receptor subtypes.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1996/10//
VL  - 8
IS  - 10
SP  - 771
EP  - 776
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - Rabii, Jamshid, Department of Biological Sciences, Rutgers University, Nelson Biological Laboratories, Piscataway, NJ, US, 08855
N1  - Accession Number: 2006-00869-001. PMID: 8910807 Partial author list: First Author & Affiliation: Callahan, Phyllis; Department of Zoology, Center for Neuroscience, Miami University, Oxford, OH, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070813. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Neural Receptors; Prolactin; Rats. Minor Descriptor: Hydroxytryptophan (5-); Narcotic Antagonists; Opiates; Sucking. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 1996. 
AB  - Previous studies have shown that mu (μ) and kappa (κ) opioid antagonists inhibit suckling-induced prolactin release. Prolactin responses elicited by pup suckling or opioid administration are mediated, at least in part, by suppression of dopamine (DA) release from tuberoinfundibular dopaminergic (TIDA) neurons in the hypothalamus. We examined the effects of the μ opiate receptor antagonist, β-funaltrexamine (β-FNA), and the κ opiate receptor antagonist, nor-binaltorphimine (nor-BNI) on the activity of TIDA neurons in lactating rats. TIDA neuronal activity was determined by measuring DOPA accumulation in the caudate putamen (CP) and median eminence (ME). The effects of opioid antagonist treatment were determined in pup-deprived (low circulating prolactin levels) or pup-suckled rats (high circulating prolactin levels). The accumulation of 5-hydroxytryptophan (5-HTP) in the medial preoptic area (MPOA), the anterior hypothalamus (AH) and the median eminence (ME) was quantified as an index of serotonergic activity in the same animals for comparative purposes. In vehicle treated rats, suckling caused a significant and selective decrease in DOPA accumulation in the ME. β-FNA (5 μg, i.c.v.) pretreatment significantly increased DOPA accumulation in the ME of pup-deprived and pup-suckled rats. β-FNA pretreatment also prevented the suckling-induced suppression of DOPA accumulation in the ME. In contrast to the actions of β-FNA, pretreatment with nor-BNI (8 μg, i.c.v.) did not significantly affect the activity of the TIDA neurons in pup-deprived or pup-suckled rats. Suckling alone did not alter 5-HTP accumulation in any of the brain regions examined, and neither opioid antagonist had appreciable effects on 5-HTP accumulation. These results demonstrate that the EOP tonically inhibit the TIDA neurons in both pup-deprived and pup-suckled, post-partum female rats by acting through the μ, but not the κ, opiate receptor subtype. Furthermore, the suckling-induced inhibition of TIDA neurons is also mediated through the EOP acting at μ, but not κ opioid receptors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - inhibition
KW  - tuberoinfundibular dopaminergic neural activity
KW  - suckling
KW  - opiate receptor subtypes
KW  - prolactin responses
KW  - 1996
KW  - Dopamine
KW  - Neural Receptors
KW  - Prolactin
KW  - Rats
KW  - Hydroxytryptophan (5-)
KW  - Narcotic Antagonists
KW  - Opiates
KW  - Sucking
KW  - 1996
DO  - 10.1046/j.1365-2826.1996.05207.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00869-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-15149-003
AN  - 2005-15149-003
AU  - Parke, Ross D.
AU  - Ornstein, Peter
AU  - Reiser, John
AU  - Zahn-Waxler, Carolyn
T1  - Meacham misses the mark.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1996/10//
VL  - 41
IS  - 10
SP  - 1071
EP  - 1072
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2005-15149-003. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Parke, Ross D.; University of California, Riverside, CA, US. Release Date: 20051223. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Developmental Psychology; History of Psychology. Classification: Developmental Psychology (2800). Population: Human (10). Page Count: 2. Issue Publication Date: Oct, 1996. 
AB  - Comments on Meacham's review (see record [rid]2004-17619-014[/rid]) of Parke, Ornstein, Reiser, and Zahn-Waxler's edited book, A Century of Developmental Psychology (see record [rid]1994-98230-000[/rid]). In his review of the book, Meacham takes the editors to task for not writing about the version of the history of developmental psychology that he would have liked to have seen written. The authors recognize that reviews serve multiple functions in addition to informing readers about the goals and content of a book under review. But in this case the authors' view is that they learned more from his review about the goals of a book that Meacham feels they ought to have compiled rather than about the book that was, in fact, under review. They do not necessarily disagree with the vision of history that Meacham offers; he ought to write such a history. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - developmental psychology
KW  - history
KW  - 1996
KW  - Developmental Psychology
KW  - History of Psychology
KW  - 1996
DO  - 10.1037/005006
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-15149-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38433-009
AN  - 2015-38433-009
AU  - Wu, Doris K.
AU  - Oh, Seung-Ha
T1  - Sensory organ generation in the chick inner ear.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/10//
VL  - 16
IS  - 20
SP  - 6454
EP  - 6462
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wu, Doris K., NIDCD, 5 Research Court, Room 2B34, Rockville, MD, US, 20850
N1  - Accession Number: 2015-38433-009. PMID: 8815924 Partial author list: First Author & Affiliation: Wu, Doris K.; National Institute on Deafness and Other Communication Disorders, Rockville, MD, US. Release Date: 20160425. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Labyrinth (Anatomy); Sense Organs. Minor Descriptor: Chickens. Classification: Physiological Processes (2540). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 1996. Publication History: Accepted Date: Jul 29, 1996; Revised Date: Jul 24, 1996; First Submitted Date: Apr 26, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - There are a total of eight sensory organs in the chick inner ear. Each sensory organ has a distinct structure tailored for its function, and its morphology is well characterized. However, the origin of these sensory organs and the lineage relationships among them are largely unknown. In this report, we show that BMP4 (bone morphogenetic protein), a secreted protein of the TGF-β gene family, is the earliest sensory marker identified to date for the chick inner ear. In addition to BMP4, we show that Msx-1 is a sensory marker for the three cristae, the lagena, and macula neglecta. P75NGFR (nerve growth factor receptor) is a marker for the three cristae only. Based on the expression pattern of these three genes—BMP4, Msx-1, and p75NGFR—it is estimated that the first sensory organs to be generated were the superior and posterior cristae at stage 19, followed by the macula sacculi at stage 20, the lateral crista at stage 22, the basilar papilla and lagena at stage 23, the macula utriculi at stage 24, and the macula neglecta at stage 29. The age of generation of each sensory organ as defined by the first appearance of these molecular markers is well in advance of the histological differentiation. In addition, the differential gene expressions in each presumptive sensory organ may contribute to the distinct structure of the mature organ. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - inner ear development
KW  - Msx-1
KW  - p75NGFR
KW  - BMP4
KW  - placode-derived
KW  - sensory organ
KW  - 1996
KW  - Labyrinth (Anatomy)
KW  - Sense Organs
KW  - Chickens
KW  - 1996
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38433-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38433-010
AN  - 2015-38433-010
AU  - Oh, Seung-Ha
AU  - Johnson, Randy
AU  - Wu, Doris K.
T1  - Differential expression of bone morphogenetic proteins in the developing vestibular and auditory sensory organs.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/10//
VL  - 16
IS  - 20
SP  - 6463
EP  - 6475
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wu, Doris K., National Institute on Deafness and Other Communication Disorders, 5 Research Court, Room 2B34, Rockville, MD, US, 20850
N1  - Accession Number: 2015-38433-010. PMID: 8815925 Partial author list: First Author & Affiliation: Oh, Seung-Ha; National Institute on Deafness and Other Communication Disorders, Rockville, MD, US. Release Date: 20160425. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bones; Gene Expression; Proteins. Minor Descriptor: Animal Models. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Oct, 1996. Publication History: Accepted Date: Jul 29, 1996; Revised Date: Jul 24, 1996; First Submitted Date: Apr 26, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - The genes responsible for the formation of various sensory organs in the inner ear are not known. There are eight sensory organs in the chick inner ear, and our previous study showed that all presumptive sensory organs initially express bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF)-β gene family. To address the potential role of BMPs in the patterning of different sensory organ structures, we investigated the expression of BMP4, BMP5, and BMP7 during sensory organ differentiation in the chick inner ear. The gene expression pattern of BMP5, although similar to that of BMP4, was transient and disappeared by embryonic day 3.5 (E3.5). In contrast, BMP7 gene expression was quite extensive, starting in the otic placode. By E5, gene expression patterns of BMP4 and BMP7 differed among vestibular and auditory sensory organs. In the vestibular sensory organs, BMP7 gene expression segregated from the main sensory tissue areas at the onset of differentiation, whereas BMP4 expression concentrated in supporting cells. In the cochlea, however, BMP7 gene expression became restricted to sensory tissue over time and eventually concentrated in supporting cells, whereas BMP4 gene expression was localized to hair cells. The different BMP expression patterns in developing auditory and vestibular sensory organs may help to shape each respective sensory structure. Furthermore, the expression of BMP4 in the cochlea also revealed an interesting pattern of sensory cell differentiation: the distal portion of the cochlea differentiates first, and the tall hair cells develop before the short hair cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - BMP4
KW  - BMP5
KW  - BMP7
KW  - crista ampullaris
KW  - basilar papilla
KW  - macula
KW  - 1996
KW  - Bones
KW  - Gene Expression
KW  - Proteins
KW  - Animal Models
KW  - 1996
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38433-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - ABST
AU  - Williams, Karen
AU  - Susla, Gregory
AU  - Temeck, Barbara K.
AU  - Pass, Harvey
T1  - PHARMACOKINETICS OF FENTANYL DURING HYPERTHERMIC, ISOLATED LUNG PERFUSION WITH TUMOR NECROSIS FACTOR.
JO  - Southern Medical Journal
JF  - Southern Medical Journal
Y1  - 1996/10/02/Oct1996 Supplement
VL  - 89
IS  - 10
M3  - Abstract
SP  - S14
EP  - S14
PB  - Lippincott Williams & Wilkins
SN  - 15418243
AB  - An abstract of the article "Pharmacokinetics Of Fentanyl During Hyperthermic, Isolated Lung Perfusion With Tumor Necrosis Factor" by Karen Williams and colleagues is presented.
N1  - Accession Number: 110619038; Williams, Karen 1 Susla, Gregory 1 Temeck, Barbara K. 1 Pass, Harvey 1; Affiliation:  1: Departments of Anesthesiology, Surgery, and Pharmacy, National Institutes of Health, Bethesda, Md.; Source Info: Oct1996 Supplement, Vol. 89 Issue 10, pS14; Number of Pages: 1p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Robbins, J B
AU  - Schneerson, R
AU  - Anderson, P
AU  - Smith, D H
T1  - The 1996 Albert Lasker Medical Research Awards. Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1996/10/09/
VL  - 276
IS  - 14
M3  - journal article
SP  - 1181
EP  - 1185
SN  - 00987484
AB  - The development of Haemophilus influenzae type b (Hib) conjugate vaccines has led to the virtual elimination of systemic infections caused by that pathogen, has provided insights into the pathogenesis of and immunity to other capsulated bacteria, and has contributed to the development of new vaccines. Meningitis, a common and serious infection of children, and other infections caused by Hib have been virtually eliminated in countries that have achieved widespread vaccination with Hib conjugates, including the United States, Canada, the United Kingdom, Iceland, Scandinavia, France, and Germany. Hib conjugates have also been shown to be highly effective in developing countries. The principles derived from the use of these vaccines, along with studies of other capsulated pathogens, should allow the rapid inclusion of new polysaccharide-based conjugates into routine vaccination schedules of infants, and should help to realize further reductions in serious systemic infectious diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 119404874; Robbins, J B 1 Schneerson, R Anderson, P Smith, D H; Affiliation:  1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2720, USA; Source Info: 10/9/96, Vol. 276 Issue 14, p1181; Number of Pages: 5p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107233473
T1  - Understanding drug addiction: implications for treatment.
AU  - Leshner AI
Y1  - 1996/10/15/
N1  - Accession Number: 107233473. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Substance Dependence -- Therapy
KW  - Cocaine -- Pharmacodynamics
KW  - Brain -- Drug Effects
KW  - Rats
KW  - Brain -- Anatomy and Histology
KW  - Animal Studies
KW  - Behavior Therapy
KW  - Education, Continuing (Credit)
SP  - 47
EP  - 173
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 31
IS  - 10
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - Director, National Institute on Drug Abuse, National Institutes of Health, Rockville, MD
U2  - PMID: 8859207.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107233473&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Marks, Michael S.
AU  - Woodruff, Lauren
AU  - Ohno, Hiroshi
AU  - Bonifacino, Juan S.
T1  - Protein Targeting by Tyrosine- and Di-leucine-based Signals: Evidence for Distinct Saturable Components.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1996/10/15/
VL  - 135
IS  - 2
M3  - Article
SP  - 341
EP  - 354
SN  - 00219525
AB  - Examines the distinct saturable components of transmembrane protein targeting by tyrosine- and di-leucine-exposed sorting signals. Implication for signals conforming to both motifs in protein localization to similar post-Golgi compartments; Overexpression of chimeric proteins containing various cytoplasmic domains and targeting signals; Accumulation of endogenous transferrin receptor and lysosomal proteins.
KW  - PROTEINS
KW  - BIOLOGICAL transport
KW  - LYSOSOMES
KW  - GOLGI apparatus
KW  - TRANSFERRIN
N1  - Accession Number: 11226193; Marks, Michael S. 1,2 Woodruff, Lauren 1 Ohno, Hiroshi 1 Bonifacino, Juan S. 1; Affiliation:  1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892  2: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; Source Info: Oct96, Vol. 135 Issue 2, p341; Subject Term: PROTEINS; Subject Term: BIOLOGICAL transport; Subject Term: LYSOSOMES; Subject Term: GOLGI apparatus; Subject Term: TRANSFERRIN; Number of Pages: 14p; Illustrations: 10 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Muresan, Virgil
AU  - Godek, Chris P.
AU  - Reese, Thomas S.
AU  - Schnapp, Bruce J.
T1  - Plus-end Motors Override Minus-end Motors during Transport of Squid Axon Vesicles on Microtubules.
JO  - Journal of Cell Biology
JF  - Journal of Cell Biology
Y1  - 1996/10/15/
VL  - 135
IS  - 2
M3  - Article
SP  - 383
EP  - 397
SN  - 00219525
AB  - Examines the isolation of plus and minus vesicle populations from squid axoplasm through selective extraction of the minus-end vesicle motor.  Reversal in the direction of movement of trypsinized plus-end vesicles; Establishment of a functional interaction with the lipid bilayers of both vesicle populations; Involvement of microtubule motors in the transport and positioning of membrane compartments.
KW  - COATED vesicles
KW  - AXONAL transport
KW  - SQUIDS
KW  - BILAYER lipid membranes
KW  - MICROTUBULES
N1  - Accession Number: 11226196; Muresan, Virgil 1 Godek, Chris P. 1 Reese, Thomas S. 2 Schnapp, Bruce J. 1; Email Address: schapp@warren.med.harvard.edu; Affiliation:  1: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115  2: Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892; Source Info: Oct96, Vol. 135 Issue 2, p383; Subject Term: COATED vesicles; Subject Term: AXONAL transport; Subject Term: SQUIDS; Subject Term: BILAYER lipid membranes; Subject Term: MICROTUBULES; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 15p; Illustrations: 5 Diagrams, 3 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Valdivia, Raphael H.
AU  - Falkow, Stanley
T1  - Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurlum acid-inducible promoters by differential fluorescence induction.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/10/15/
VL  - 22
IS  - 2
M3  - Article
SP  - 367
EP  - 378
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The ability of <em>Salmonella typhimurium</em> to survive and replicate within murine macrophages is dependent on a low phagosomal pH. This requirement for an acidic vacuole suggests that low pH is an important environmental stimulus for the transcription of genes necessary for intracellular survival. To study the behaviour of acid-inducible genes in response to the phagosomal environment, we have applied a novel enrichment strategy, termed ḏifferential f̱luorescence induction (DFI), to screen an <em>S. typhimurium</em> library for promoters that are upregulated at pH 4.5. DFI utilizes a fluorescence-enhanced green fluorescent protein (GFP) and a f̱luorescence-a̱ctivated c̱ell s̱orter (FACS) to perform genetic selection. In the presence of an inducing stimulus, such as low pH, a FACS is used to sort highly fluorescent bacterial clones bearing random promoters fused to the mutant GFP protein (GFPmut). This population is then amplified at neutral pH and the least fluorescent population is sorted. Sequential sorts for fluorescent and nonfluorescent bacteria in the presence or absence of inducing conditions rapidly enriches for promoter fusions that are regulated by the inducing stimulus. We have identified eight acid-inducible promoters and quantified their expression in response to pH4.5 and to the phagosome milieu. These acid-inducible promoters exhibited extensive homology to promoter regions of genes encoding for cell-surface-maintenance enzymes, stress proteins, and generalized efflux pumps. Only a subset of these promoters was induced in macrophages with kinetics and levels of expression that do not necessarily correlate with in vitro pH-shock induction. This suggests that while low pH is a relevant inducer of intracellular gene expression, additional stimuli in the macrophage can modulate the expression of acid-inducible genes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Bacterial genetics
KW  - Salmonella typhimurium
KW  - Macrophages
KW  - Green fluorescent protein
KW  - Genes
N1  - Accession Number: 21342182; Valdivia, Raphael H. 1; Email Address: valdivia@cmgm.stanford.edu; Falkow, Stanley 1,2; Affiliations: 1: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA; 2: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA; Issue Info: Oct1996, Vol. 22 Issue 2, p367; Thesaurus Term: Bacterial genetics; Subject Term: Salmonella typhimurium; Subject Term: Macrophages; Subject Term: Green fluorescent protein; Subject Term: Genes; Number of Pages: 12p; Illustrations: 3 Diagrams, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107263545
T1  - Bone mineral density in women with depression.
AU  - Michelson D
AU  - Stratakis C
AU  - Hill L
AU  - Reynolds J
AU  - Galliven E
AU  - Chrousos G
AU  - Gold P
Y1  - 1996/10/17/
N1  - Accession Number: 107263545. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Depression -- Physiopathology
KW  - Bone Density
KW  - Case Control Studies
KW  - Interviews
KW  - Psychological Tests
KW  - T-Tests
KW  - McNemar's Test
KW  - Analysis of Covariance
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Radius -- Physiology
KW  - Radius -- Physiopathology
KW  - Hydrocortisone
KW  - Reference Values
KW  - Absorptiometry, Photon
KW  - Depression -- Metabolism
KW  - Hip Joint -- Physiology
KW  - Hip Joint -- Physiopathology
KW  - Spine -- Physiopathology
KW  - Spine -- Physiology
KW  - Bone and Bones -- Metabolism
KW  - Human
SP  - 1176
EP  - 1181
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 335
IS  - 16
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Warren G. Magnuson Clinical Center, Room 2D 46, MSC 1284, National Institutes of Health, Bethesda, MD 20892-1284
U2  - PMID: 8815939.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107263545&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265667
T1  - Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus.
AU  - Kovacs JA
AU  - Vogel S
AU  - Albert JM
AU  - Falloon J
AU  - Davey RT Jr.
AU  - Walker RE
AU  - Polis MA
AU  - Spooner K
AU  - Metcalf JA
AU  - Baseler M
AU  - Fyfe G
AU  - Lane HC
Y1  - 1996/10/31/
N1  - Accession Number: 107265667. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Interleukin 2 -- Therapeutic Use
KW  - HIV Infections -- Therapy
KW  - Interleukin 2 -- Administration and Dosage
KW  - Treatment Outcomes
KW  - T-Tests
KW  - Linear Regression
KW  - Viral Load
KW  - Human Immunodeficiency Virus
KW  - Drug Therapy, Combination
KW  - CD4 Lymphocyte Count
KW  - Antiviral Agents -- Therapeutic Use
KW  - Immunity
KW  - Clinical Trials
KW  - Male
KW  - Middle Age
KW  - Adult
KW  - Female
KW  - AIDS-Related Opportunistic Infections -- Mortality
KW  - Human
SP  - 1350
EP  - 1356
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 335
IS  - 18
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Bldg. 10, Rm 7D43, MSC 1662, National Institutes of Health, Bethesda, MD 20892-1662
U2  - PMID: 8857018.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107265667&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104792692
T1  - Temporal drinking patterns and variation in social consequences.
AU  - Dawson, D A
Y1  - 1996/11//
N1  - Accession Number: 104792692. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcohol Drinking -- Epidemiology
KW  - Alcoholism -- Epidemiology
KW  - Social Problems
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Alcohol Drinking
KW  - Alcoholism -- Psychosocial Factors
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Incidence
KW  - Male
KW  - Middle Age
KW  - Risk Factors
KW  - Social Adjustment
KW  - Social Problems -- Psychosocial Factors
KW  - United States
SP  - 1623
EP  - 1635
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 91
IS  - 11
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Temporal drinking patterns and their associated social consequences are described for a sample of US adults aged 18 years and over who drank at least 12 drinks in the preceding year and did not restrict their drinking to special occasions (n = 16086). The earliest time of day when these current regular drinkers reported usually drinking was between 6 a.m. and 11 a.m. for 1.2%, between 11 a.m. and 3 p.m. for 7.3%, between 3 p.m. and 6 p.m. for 31.2%, and after 6 p.m. for 60.3%. Less than one-tenth (7.7%) reported any drinking (not necessarily their earliest drinking) between midnight and 6 a. m. Characteristics associated with above-average rates of both early (6 a.m.-3 p.m.) and late-night (midnight-6 a.m.) drinking included male gender, black race, low education and income and heavy quantity of ethanol intake per drinking day. Early drinking was also characteristic of the elderly and daily drinkers. Prior to adjusting for background variables and quantity and frequency of intake, early drinking was associated with a two- to nine-fold increase in the risk of alcohol-related interpersonal problems, hazardous use, job/school problems and legal problems, and late-night drinking was associated with a three- to eight-fold increase in their prevalence. After adjusting for these factors in multiple logistic regression models, early drinking was associated with a 54% increase in the odds of interpersonal problems, a 39% increase in the odds of hazardous use and a 52% increase in the odds of legal problems. The association between early drinking and job/school problems fell just short of statistical significance. After adjusting for other factors, late-night drinking retained a significant association with all of the outcomes except legal problems. The magnitude of its association was greater than that of early drinking but varied substantially (i.e. interacted) with quantity of intake, race, ethnicity and gender.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-7003, USA.
U2  - PMID: 8972921.
DO  - 10.1111/j.1360-0443.1996.tb02266.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107318762
T1  - Cardiovascular risk factors and hyperinsulinemia in elderly men: the Honolulu Heart Program.
AU  - Burchfiel CM
AU  - Curb JD
AU  - Arakaki R
AU  - Abbott RD
AU  - Sharp DS
AU  - Rodriguez BL
AU  - Yano K
Y1  - 1996/11//1996 Nov
N1  - Accession Number: 107318762. Language: English. Entry Date: 19970401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Supported by contract NO1-05102 from the National Heart, Lung, and Blood Institute, Bethesda, MD. NLM UID: 9100013. 
KW  - Hyperinsulinism
KW  - Cardiovascular Risk Factors
KW  - Glucose Tolerance Test
KW  - Japanese -- United States
KW  - United States -- Ethnology
KW  - Adipose Tissue
KW  - Body Composition
KW  - Lipoproteins -- Analysis
KW  - Blood Glucose -- Analysis
KW  - Insulin -- Analysis
KW  - Time Factors
KW  - Prevalence
KW  - Prospective Studies
KW  - Epidemiological Research
KW  - Chi Square Test
KW  - Logistic Regression
KW  - Multiple Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Statistical Significance
KW  - Descriptive Statistics
KW  - Funding Source
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Human
SP  - 490
EP  - 497
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 6
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - Associations of cardiovascular risk factors, including several measures of adiposity, with hyperinsulinemia were assessed in 3562 elderly (71 to 93 years of age) Japanese American men from the Honolulu Heart Program who were examined between 1991 and 1993. In addition, cardiovascular risk factors measured 25 years earlier were also examined in relation to hyperinsulinemia. Hyperinsulinemia was defined as fasting insulin >/= 95th percentile (20 microU/mL) among the subset of subjects (n = 504) who were nonobese and free of clinical diabetes and glucose intolerance. When this definition was applied to the entire population, the prevalence of hyperinsulinemia declined cross-sectionally with age (P < 0.001) from 24.2% in men aged 71 to 74 years to 16.4% in men aged 85 to 93 years. Factors having a positive and independent association with hyperinsulinemia included body mass index (BMI), triglycerides, glucose, hematocrit, use of diabetic medication, heart rate, and hypertension. The association with physical activity was negative. Triglycerides, BMI, diabetic medication, hypertension, and smoking levels measured 25 years earlier were also associated independently with hyperinsulinemia. Associations were similar in nondiabetic subjects. Three measures of adiposity (BMI, waist circumference and subscapular skinfold thickness) were independently related to hyperinsulinemia cross-sectionally. However, associations involving a difference between the 80th and 20th percentiles in each adiposity measure appeared strongest for BMI (odds ratio (OR) = 4.5, 95% confidence interval (CI) = 3.7 to 5.6) and waist circumference (OR = 4.1, 95% CI = 3.3-5.1) and slightly weaker for subscapular skinfold thickness (OR = 2.1, 95% CI = 1.8-2.5). These findings suggest that features of an insulin resistance syndrome including dyslipidemia, glucose intolerance, hypertension, and obesity, assessed both cross-sectionally and 25 years previously, are associated independently with hyperinsulinemia in elderly Japanese American men. (C) 1996 by Elsevier Science Inc.
SN  - 1047-2797
AD  - Honolulu Heart Program, National Heart, Lung, and Blood Institute, 347 North Kuakini Street, Honolulu, HI 96817
U2  - PMID: 8978879.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107352331
T1  - Cervical adenopathy: a clinical approach to diagnosis.
AU  - Longo DL
AU  - Arun B
Y1  - 1996/11//
N1  - Accession Number: 107352331. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; pictorial; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110. 
KW  - Lymphatic Diseases -- Diagnosis
KW  - Lymphatic Diseases -- Etiology
KW  - Lymph Nodes -- Pathology
KW  - Neck
KW  - Lymphatic System -- Physiology
KW  - Physical Examination
KW  - Patient Selection
KW  - Biopsy
SP  - 2345
EP  - 2352
JO  - Consultant (00107069)
JF  - Consultant (00107069)
JA  - CONSULTANT
VL  - 36
IS  - 11
CY  - Framingham, Massachusetts
PB  - United Business Media
AB  - Cervical adenopathy has many causes, including a variety of infections, malignancies, and immunologic disorders. It is usually benign in young persons, but the likelihood of malignancies increases with advanced age. Generalized adenopathy suggests systemic infection or lymphoma. Localized cervical adenopathy requires a careful examination of the scalp, eyes and conjunctiva, ears, nose, and throat. Associated signs and symptoms help focus the workup -- for example, fever, night sweats, and weight loss may signal malignancy, while the presence of on exanthem suggests viral infection. The likelihood of malignancy is increased if the node is nontender, 'rock hard,' and larger than 2.25 cm2. Immediate biopsy is indicated if the node is larger than 4 cm2. Serologic studies are not routinely indicated but are more likely to be useful if the patient has generalized adenopathy or systemic symptoms.
SN  - 0010-7069
AD  - National Institute on Aging, National Institutes of Health, Baltimore
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107312550
T1  - Serum lipids and diabetic retinopathy. Early Treatment Diabetic Retinopathy Study Research Group.
AU  - Ferris FL III
AU  - Chew EY
AU  - Hoogwerf BJ
AU  - Ferris, F L 3rd
AU  - Chew, E Y
AU  - Hoogwerf, B J
Y1  - 1996/11//
N1  - Accession Number: 107312550. Corporate Author: Early Treatment Diabetic Retinopathy Study Research Group. Language: English. Entry Date: 19970201. Revision Date: 20161118. Publication Type: journal article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Z99 EY999999//Intramural NIH HHS/United States. NLM UID: 7805975. 
KW  - Diabetic Retinopathy
KW  - Lipids -- Adverse Effects
KW  - Diabetic Retinopathy -- Physiopathology
SP  - 1291
EP  - 1293
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 19
IS  - 11
CY  - Alexandria, Virginia
PB  - American Diabetes Association
SN  - 0149-5992
AD  - National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2510, USA
AD  - National Eye Institute, National Institutes of Health, Bldg 31, Room 6A52, 31 Center Dr MSC 2510, Bethesda, MD 20892-2510
U2  - PMID: 8908399.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - GEORGE, JULIA D.
AU  - FAIL, PATRICIA A.
AU  - GRIZZLE, THOMAS B.
AU  - HEINDEL, JERROLD J.
T1  - Nitrofurazone: Reproductive Assessment by Continuous Breeding in Swiss Mice1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/11//
VL  - 34
IS  - 1
M3  - Article
SP  - 56
EP  - 66
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Nitrofurazone (NTFZ), a nitrofuran antibiotic, was evaluated for reproductive toxicity in Swiss CD-1 mice using the Reproductive Assessment by Continuous Breeding protocol. Male and female mice were cohabited for 15 weeks and exposed to NTFZ in feed at concentrations of 0, 100, 375, and 750 ppm (14–102 mg/kg/day). F0 750-ppm breeding pairs had significantly reduced fertility after 7 days of exposure to NTFZ (17% fertile compared to 98% for control pairs) and were infertile after the second litter. F0 mid-dose pairs had progressively decreasing fertility (47% by the fifth litter), reduced litter size, and reduced proportion of pups born alive. Crossover breeding of control and high-dose F0 animals confirmed infertility in high-dose males and reduced litter size and pup weight in high-dose females when compared to the control×control group. At necropsy, there were no effects on body weight, but F0 males had reduced testis weight at the high dose and reduced epididymal sperm concentration and abnormal sperm morphology at all doses of NTFZ. Increased liver as well as kidney and adrenal weights (combined) were observed at 375 and 750 ppm; hepatic hypertrophy was noted microscopically at 750 ppm. F0 females had reduced body weight, hepatic hypertrophy, and altered estrous cycles at 750 ppm and reduced ovarian weight at all doses. In the second generation, F1 mice at 375 ppm had reduced postnatal survival and body weight and produced smaller F2 litters compared to control mice. At necropsy, F1 males had reduced testes weight and epididymal sperm concentration, abnormal sperm morphology, hepatic hypertrophy at 375 ppm, and borderline nephropathy at 100 and 375 ppm. F1 females had decreased body, liver, and ovarian weight at 375 ppm and altered estrous cycles at 100 and 375 ppm. Thus, NTFZ at ≥100 ppm (≥ 14 mg/kg/day) caused adverse reproductive effects in F0 male and female and F1 female mice in the presence of relatively mild systemic toxicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BREEDING
KW  - Nitrofurans
KW  - Mice
KW  - Fertility
KW  - Autopsy
KW  - Body weight
KW  - Hypertrophy
N1  - Accession Number: 82415660; GEORGE, JULIA D. 1,2; FAIL, PATRICIA A. 1,2; GRIZZLE, THOMAS B. 1,2; HEINDEL, JERROLD J. 2; Affiliations: 1: Laboratory of Reproductive Toxicology, Chemistry and life Sciences Division, Center for Life Sciences and Toxicology, Research Triangle Institute P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194; 2: Developmental and Reproductive Toxicology Croup, National Toxicology Program, National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; Issue Info: 1996, Vol. 34 Issue 1, p56; Thesaurus Term: BREEDING; Subject Term: Nitrofurans; Subject Term: Mice; Subject Term: Fertility; Subject Term: Autopsy; Subject Term: Body weight; Subject Term: Hypertrophy; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107316400
T1  - Body composition in clinically stable men with HIV infection.
AU  - Grady C
AU  - Ropka M
AU  - Anderson R
AU  - Lane HC
Y1  - 1996/11//1996 Nov-Dec
N1  - Accession Number: 107316400. Language: English. Entry Date: 19970401. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111870. 
KW  - Body Composition
KW  - HIV Infections -- Complications
KW  - Cachexia
KW  - Body Weights and Measures
KW  - Drugs, Investigational
KW  - Prospective Studies
KW  - Observational Methods
KW  - AIDS Patients
KW  - CD4 Lymphocyte Count
KW  - Cross Sectional Studies
KW  - Analysis of Variance
KW  - P-Value
KW  - Descriptive Statistics
KW  - Logistic Regression
KW  - Nutritional Status
KW  - Weight Loss
KW  - Muscles
KW  - Proteins
KW  - Adipose Tissue
KW  - Male
KW  - Human
SP  - 29
EP  - 38
JO  - JANAC: Journal of the Association of Nurses in AIDS Care
JF  - JANAC: Journal of the Association of Nurses in AIDS Care
JA  - J ASSOC NURSES AIDS CARE
VL  - 7
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - Clinically stable HIV-infected men (N = 106) receiving investigational antiretrovirals were recruited. Subjects were divided into three HIV disease severity groups by CD4+ cell count. Standard measures of body composition were assessed, as well as serum measures of visceral protein stores and kilocalorie intake. Group 1 subjects (CD4+ T cells<200) had significantly lower measures of body fat as compared with Group 2 (CD4 between 200 and 600) and Group 3 (CD4>600) despite adequate kilocalorie intake. Group 2 and Group 3 were not significantly different from each other. Our entire cohort had significantly lower muscle mass compared to norms. Our data demonstrate that people with advanced HIV disease have reduced muscle and fat.
SN  - 1055-3290
AD  - Clinical Therapeutics Laboratory, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 9021634.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Tanaka, Eriko
AU  - Sakamoto, Shinji
AU  - Ono, Yutaka
AU  - Fujihara, Shigeki
AU  - Kitamura, Toshinori
T1  - Hopelessness in a community population in Japan.
JO  - Journal of Clinical Psychology
JF  - Journal of Clinical Psychology
Y1  - 1996/11//
VL  - 52
IS  - 6
M3  - Article
SP  - 609
EP  - 615
PB  - John Wiley & Sons, Inc.
SN  - 00219762
AB  - The Japanese version of the Beck Hopelessness Scale was administered to a total of 154 community residents. The internal consistency (KR-20) was .86. The mean BHS score was 8.6 (SD = 3.9), approximately one standard deviation higher than the reported mean for an Irish general population. The BHS scores were found to be significantly correlated with the age and the number of people living together. Significant negative correlations were found with subjective physical fitness, self-confidence, satisfaction with accommodation and marital state, and adjustment in the work place. The mean BHS score was significantly higher among those individuals who had experienced early maternal or paternal death than those individuals who had experienced early maternal or paternal death than those who had not. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BECK Hopelessness Scale
KW  - DESPAIR
KW  - DESPAIR -- Testing
KW  - BEREAVEMENT
KW  - PARENTS -- Death
KW  - BEREAVEMENT -- Psychological aspects
KW  - JAPAN
N1  - Accession Number: 9704173473; Tanaka, Eriko 1 Sakamoto, Shinji 2 Ono, Yutaka 3 Fujihara, Shigeki 4 Kitamura, Toshinori 1; Affiliation:  1: National Institute of Mental Health NCNP, Chiba, Japan  2: The University of Tokyo, Tokyo, Japan  3: Keio University School of Medicine, Tokyo, Japan  4: Yamanashi Prefectural Mental Health and Welfare Center, Yamanashi, Japan; Source Info: Nov1996, Vol. 52 Issue 6, p609; Subject Term: BECK Hopelessness Scale; Subject Term: DESPAIR; Subject Term: DESPAIR -- Testing; Subject Term: BEREAVEMENT; Subject Term: PARENTS -- Death; Subject Term: BEREAVEMENT -- Psychological aspects; Subject Term: JAPAN; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Crnic, Linda S.
AU  - Ralph M.Nitkin, Linda S.
T1  - ANIMAL MODELS OF MENTAL RETARDATION: AN OVERVIEW.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1996/11//
VL  - 2
IS  - 4
M3  - Article
SP  - 185
EP  - 187
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - The science of mental retardation research is at a tremendously exciting point in its development. Genetic and environmental factors responsible for many types of mental retardation are rapidly being uncovered, and animal models are being developed. In most instances, animal models are critical for understanding the mechanisms by which adverse events cause mental retardation and for testing potential therapies. This issue of "Mental Retardation and Developmental Disabilities Research Reviews," was designed to provide an overview of recent developments in animal models of mental retardation.
KW  - PEOPLE with mental disabilities
KW  - DEVELOPMENTAL disabilities
KW  - LABORATORY animals
KW  - DISABILITIES
KW  - BRAIN diseases
KW  - DEVELOPMENTALLY disabled
N1  - Accession Number: 12388943; Crnic, Linda S. 1 Ralph M.Nitkin, Linda S. 2; Affiliation:  1: University of Colorado School of Medicine, Denver, Colorado.  2: Mental Retardation and Developmental Disabilities Branch, National Institute of Child Health and Human Development (National Institute of Health).; Source Info: 1996, Vol. 2 Issue 4, p185; Subject Term: PEOPLE with mental disabilities; Subject Term: DEVELOPMENTAL disabilities; Subject Term: LABORATORY animals; Subject Term: DISABILITIES; Subject Term: BRAIN diseases; Subject Term: DEVELOPMENTALLY disabled; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eiden, Lee E.
T1  - PRIMATE LENTIVIRUS-ASSOCIATED ENCEPHALOPATHY.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1996/11//
VL  - 2
IS  - 4
M3  - Article
SP  - 257
EP  - 263
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - Rhesus monkeys infected with simian immunodeficiency virus (SIV), a lentivirus closely related to human immunodefieciency virus (HIV), develop AIDS and encephalopathy with a frequency similar to that of HIV-infected humans. The pathogenic relationships among systemic virus infection, central nervous system (CNS) inflammation and immune activation, viral infection of the CNS, and clinical encephalopathy are still very poorly understood in HIV disease. Most puzzling is the apparent fack of correlation between extent of virus infection and degree of encephalopathy in human AIDS. This has focus attention on indirect mechanisms of viral insult to the brain. These include generation of neurotoxins and inflammatory mediators in the CNS, and activation or dysregulation of microglia, glia, and neurons. Cellular and neurochemical processes triggered initially by virus infection and leading to encephalopathy can be systematically studied in the SIV-infected rhesus monkey. These same processes, perhaps triggered by other viruses, or by inflammatory events occurring during critical periods of development, may also be involved in other types of human encephalopathy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RHESUS monkey
KW  - HIV infections
KW  - BRAIN diseases
KW  - HEPATIC encephalopathy
KW  - BRAIN damage
KW  - AIDS (Disease)
KW  - encephalitis
KW  - encephalopathy
KW  - HIV
KW  - motor/cognitive impairment.
KW  - SIV
N1  - Accession Number: 12389108; Eiden, Lee E. 1; Affiliation:  1: Section on Molecular Neuroscience, Laboratory of Biology, National Institute of Mental Health, National Institutes of Health, Bethesda Maryland.; Source Info: 1996, Vol. 2 Issue 4, p257; Subject Term: RHESUS monkey; Subject Term: HIV infections; Subject Term: BRAIN diseases; Subject Term: HEPATIC encephalopathy; Subject Term: BRAIN damage; Subject Term: AIDS (Disease); Author-Supplied Keyword: encephalitis; Author-Supplied Keyword: encephalopathy; Author-Supplied Keyword: HIV; Author-Supplied Keyword: motor/cognitive impairment.; Author-Supplied Keyword: SIV; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zahn, Theodore P.
AU  - Kruesi, Markus J. P.
AU  - Swedo, Susan E.
AU  - Leonard, Henrietta L.
AU  - Rapoport, Judith L.
T1  - Autonomic activity in relation to cerebrospinal fluid neurochemistry in obsessive and disruptive children and adolescents.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1996/11//
VL  - 33
IS  - 6
M3  - Article
SP  - 731
EP  - 739
SN  - 00485772
AB  - Electrodermal activity and heart rate were recorded during rest, simple tones, and a reaction time task in 43 male and female adolescents and children with obsessive compulsive disorder and 30 male adolescents and children with disruptive behavior disorders who had lumbar cerebrospinal fluid drawn during the same week. Partial correlations controlling for age and sex showed that in the obsessive group metabolites of serotonin and dopamine, but not of norepinephrine, were positively correlated with electrodermal responsivity, most consistently in the reaction time task. This result was not replicated in disruptive boys. Adrenocorticotropic hormone was positively related to electrodermal activity and heart rate throughout the session. The results for the obsessive adolescents suggest that nigrostriatal dopamine turnover and central serotonin turnover affect electrodermal activity, generally confirming and extending conclusions from pharmacological studies. Diagnosis may affect these relationships. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GALVANIC skin response
KW  - CEREBROSPINAL fluid
KW  - NEUROCHEMISTRY
KW  - HEART beat
KW  - ACTH (Hormone)
KW  - OBSESSIVE-compulsive disorder
KW  - NEUROSES
KW  - Adrenocorticotropic hormone
KW  - Cerebrospinal fluid
KW  - Electrodermal activity
KW  - Heart rate
KW  - Monoamines
KW  - Obsessive compulsive disorder
N1  - Accession Number: 11728889; Zahn, Theodore P. 1; Email Address: ted_zahn@nih.gov. Kruesi, Markus J. P. 2 Swedo, Susan E. 2 Leonard, Henrietta L. 2 Rapoport, Judith L. 2; Affiliation:  1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, USA.  2: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA.; Source Info: Nov1996, Vol. 33 Issue 6, p731; Subject Term: GALVANIC skin response; Subject Term: CEREBROSPINAL fluid; Subject Term: NEUROCHEMISTRY; Subject Term: HEART beat; Subject Term: ACTH (Hormone); Subject Term: OBSESSIVE-compulsive disorder; Subject Term: NEUROSES; Author-Supplied Keyword: Adrenocorticotropic hormone; Author-Supplied Keyword: Cerebrospinal fluid; Author-Supplied Keyword: Electrodermal activity; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Monoamines; Author-Supplied Keyword: Obsessive compulsive disorder; Number of Pages: 9p; Document Type: Article
L3  - 10.1111/1469-8986.ep11728889
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11728889&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2008-09777-006
AN  - 2008-09777-006
AU  - Lytle, Leslie A.
AU  - Ebzery, Mary Kay
AU  - Nicklas, Theresa
AU  - Montgomery, Deanna
AU  - Zive, Michelle
AU  - Evans, Marguerite
AU  - Snyder, Patricia
AU  - Nichaman, Milton
AU  - Kelder, Steven H.
AU  - Reed, Debra
AU  - Busch, Ellen
AU  - Mitchell, Paul
T1  - Nutrient intakes of third graders: Results from the Child and Adolescent Trial for Cardiovascular Health (CATCH) baseline survey.
JF  - Journal of Nutrition Education
JO  - Journal of Nutrition Education
JA  - J Nutr Educ
Y1  - 1996/11//
VL  - 28
IS  - 6
SP  - 338
EP  - 347
CY  - Canada
PB  - BC Decker
SN  - 0022-3182
AD  - Lytle, Leslie A., Division of Epidemiology, School of Public Health, 1300 South Second Street, Suite 300, Minneapolis, MN, US, 55454
N1  - Accession Number: 2008-09777-006. PMID: 18160975 Other Journal Title: Journal of Nutrition Education and Behavior. Partial author list: First Author & Affiliation: Lytle, Leslie A.; School of Public Health, Division of Epidemiology, University of Minnesota, Minneapolis, MN, US. Other Publishers: Elsevier Science. Release Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cardiovascular System; Food Intake; Health; Human Sex Differences. Minor Descriptor: Diets; Nutrition; Pediatrics. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 1996. 
AB  - The purpose of this article is to report on baseline intakes of 1874 third-grade children representing a subsample of the Child and Adolescent Trial for Cardiovascular Health (CATCH) cohort. Intakes were assessed using a single, food record-assisted, 24-hour recall. The sample is unique in that it is drawn from four states and includes students from various ethnic backgrounds. Nutrients of interest include total energy, sodium, dietary cholesterol, and percent of energy from total fat and saturated fat. At baseline, third-grade students were consuming above nationally recommended levels of energy from fat, saturated fat, and sodium. The CATCH findings show a mean energy intake of 2031 kcal with significant differences by sex. Significant differences by site were seen for percent of energy from total fat, saturated fat, and dietary cholesterol. Children from Minnesota consumed the lowest proportion of energy from total fat and saturated fat while children from Texas had the highest proportion of energy from total fat and saturated fat. Intake of dietary cholesterol was lowest in Minnesota and highest in Louisiana. Nutrient differences by ethnic group were seen only for energy, with African Americans having the highest energy intake and Hispanics having the lowest energy intake.The number of meals consumed from school food service significantly influenced children's nutrient intake; children consuming two meals from school food service had significantly greater intakes of energy, saturated fat, and dietary cholesterol compared to students consuming one or no meals from school food service. The results are compared to other national nutritional surveys of children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nutrient intake
KW  - cardiovascular health
KW  - children
KW  - sex differences
KW  - diets
KW  - 1996
KW  - Cardiovascular System
KW  - Food Intake
KW  - Health
KW  - Human Sex Differences
KW  - Diets
KW  - Nutrition
KW  - Pediatrics
KW  - 1996
U1  - Sponsor: National Heart, Lung, and Blood Institute, US. Grant: U01 HL 39927; U01 HL 39852; U01 HL 39870; U01 HL 33906; U01 HL 39880. Recipients: No recipient indicated
DO  - 10.1016/S0022-3182(96)70123-1
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09777-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17624-034
AN  - 2004-17624-034
AU  - Jensen, Peter S.
T1  - Adolescent psychiatry: Help wanted.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1996/11//
VL  - 41
IS  - 11
SP  - 1133
EP  - 1134
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17624-034. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Jensen, Peter S.; Child and Adolescent Disorders Research Branch of the National Institute of Mental Health, Rockville, MD, US. Release Date: 20040927. Correction Date: 20170130. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Adolescent Psychiatry; Adolescent Psychotherapy; Mental Health; Mental Health Services. Minor Descriptor: Mental Disorders. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Reviewed Item: Marohn, Richard C. (Ed); Feinstein, Sherman C. (Ed). Adolescent Psychiatry: Developmental and Clinical Studies (Vol. 20)=Hillsdale, NJ: Analytic Press, 1995. 471 pp. $45.00; 1995. References Available: Y. Page Count: 2. Issue Publication Date: Nov, 1996. 
AB  - Review of Adolescent Psychiatry: Developmental and Clinical Studies (Vol. 20) edited by Richard C. Marohn and Sherman C. Feinstein (see record [rid]1995-97543-000[/rid]). This volume is the 20th in a series from the Annals of the American Society for Adolescent Psychiatry and encompasses a wide range of papers, including previously unpublished papers from early thinkers-theorists in the field of adolescent psychiatry, reviews of the history of adolescent psychiatry, contemporary summaries of major issues and specific syndromes of adolescence, and overviews of current treatment modalities. The first section of the volume is titled 'History,' and helps to demarcate the conceptual and empirical progress that has been made since the early days of Freudian theory and therapy. Although a substantial body of research has moved the adolescent mental health field well beyond the realm of speculation, too many chapters of this volume did not keep pace, and the volume falls short of providing a comprehensive, cross-disciplinary, empirically based resource concerning clinical and developmental issues for adolescents in our society. The most noticeable shortcoming was the lack of empirical information concerning the interactions between biological and social-psychological-cultural factors in adolescent mental health and illness. Though research and conceptual strides have been made in recent years, for the most part research in children and adolescents has lagged behind comparable research in adults. The authors encourage others to apply current research tools and empirical approaches to the study of this much underserved population. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - adolescent psychiatry
KW  - developmental studies
KW  - clinical studies
KW  - adolescent disorders
KW  - adolescent mental health
KW  - developmental issues
KW  - empirical approaches
KW  - treatment modalities
KW  - 1996
KW  - Adolescent Development
KW  - Adolescent Psychiatry
KW  - Adolescent Psychotherapy
KW  - Mental Health
KW  - Mental Health Services
KW  - Mental Disorders
KW  - 1996
U2  - Marohn, Richard C. (Ed); Feinstein, Sherman C. (Ed). (1995); Adolescent Psychiatry: Developmental and Clinical Studies (Vol. 20); Hillsdale, NJ: Analytic Press, 1995. 471 pp. $45.00; 0-88163-194-9 (Hardcover); 0-226-24064-9 (Paperback).
DO  - 10.1037/003225
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17624-034&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13547-018
AN  - 2008-13547-018
AU  - Tirindellil, Roberto
AU  - Ryba, Nicholas J. P.
T1  - The G-protein γ-subunit Gγ8 is expressed in the developing axons of olfactory and vomeronasal neurons.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1996/11//
VL  - 8
IS  - 11
SP  - 2388
EP  - 2398
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Tirindellil, Roberto, Istituto di Fisiologia Umana, Universita di Parma, via Gramsci 14, 43100, Parma, Italy
N1  - Accession Number: 2008-13547-018. Partial author list: First Author & Affiliation: Tirindellil, Roberto; Istituto di Fisiologia Umana, Universita di Parma, Parma, Italy. Other Publishers: Blackwell Publishing. Release Date: 20100927. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Axons; Proteins; Sensory Neurons. Minor Descriptor: Olfactory Perception; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Nov, 1996. Publication History: Accepted Date: Jul 10, 1996; Revised Date: Jul 5, 1996; First Submitted Date: Apr 22, 1996. Copyright Statement: European Neuroscience Association
AB  - The tissue localization of the G-protein γ-subunit, Gγ8, that is specifically expressed in the olfactory and vomeronasal neurons, was studied in rats at different ages: embryonic day 16, postnatal days 1, 7, 14 and 35, and adult. G8 appears to be a specific marker of the immature olfactory and vomeronasal neurons. Its distribution differs from that of Golfa, a G-protein a-subunit which is predominantly expressed in mature olfactory neurons. G8 immunoreactivity indicates that an undifferentiated organization of the olfactory epithelium persists up to 3 weeks of age, though neonates possess a functional sense of smell. Gγ8 accumulates at the highest levels in the axons of the developing olfactory neurons 2 weeks after birth (postnatal day 14). Moreover, up to postnatal day 14, Gy8-positive neurons are present in the region of the olfactory and vomeronasal epithelium, where they are not observed in later life. In the olfactory epithelium and in the bulb, Gγ8 expression becomes weaker and patchy with increasing age, suggesting that the process of continuous regeneration of olfactory neurons occurs in discrete areas. G8-enhanced expression following axotomy indicates that this system is potentially active throughout life. Conversely, in the vomeronasal epithelium Gγ8 expression persists virtually unmodified in the adult. This indicates that the degree of differentiation may differ between olfactory and vomeronasal neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - G-protein γ-subunit Gγ8
KW  - axons
KW  - olfactory neurons
KW  - vomeronasal neurons
KW  - rats
KW  - 1996
KW  - Axons
KW  - Proteins
KW  - Sensory Neurons
KW  - Olfactory Perception
KW  - Rats
KW  - 1996
DO  - 10.1111/j.1460-9568.1996.tb01202.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13547-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38437-002
AN  - 2015-38437-002
AU  - Partin, Kathryn M.
AU  - Fleck, Mark W.
AU  - Mayer, Mark L.
T1  - AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/11//
VL  - 16
IS  - 21
SP  - 6634
EP  - 6647
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mayer, Mark L., LCMN, NICHD, National Institutes of Health, Building 49/Room 5A78, 49 Convent Drive MSC 4495, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-38437-002. PMID: 8824304 Partial author list: First Author & Affiliation: Partin, Kathryn M.; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Glutamic Acid; Mutations; Neural Receptors; AMPA. Minor Descriptor: mRNA. Classification: Genetics (2510). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: Nov, 1996. Publication History: Accepted Date: Aug 6, 1996; Revised Date: Jul 30, 1996; First Submitted Date: Jun 24, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - AMPA receptor GluRA subunits with mutations at position 750, a residue shown previously to control allosteric regulation by cyclothiazide, were analyzed for modulation of deactivation and desensitization by cyclothiazide, aniracetam, and thiocyanate. Point mutations from Ser to Asn, Ala, Asp, Gly, Gln, Met, Cys, Thr, Leu, Val, and Tyr were constructed in GluRAflip. The last four of these mutants were not functional; S₇₅₀D was active only in the presence of cyclothiazide, and the remaining mutants exhibited altered rates of deactivation and desensitization for control responses to glutamate, and showed differential modulation by cyclothiazide and aniracetam. Results from kinetic analysis are consistent with aniracetam and cyclothiazide acting via distinct mechanisms. Our experiments demonstrate for the first time the functional importance of residue 750 in regulating intrinsic channel-gating kinetics and emphasize the biological significance of alternative splicing in the M3–M4 extracellular loop. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptors
KW  - cyclothiazide
KW  - aniracetam
KW  - thiocyanate
KW  - mutagenesis
KW  - AMPA
KW  - desensitization
KW  - deactivation
KW  - alternative splicing
KW  - flip and flop
KW  - 1996
KW  - Glutamic Acid
KW  - Mutations
KW  - Neural Receptors
KW  - AMPA
KW  - mRNA
KW  - 1996
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38437-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38437-027
AN  - 2015-38437-027
AU  - Delaney, Catherine L.
AU  - Brenner, Michael
AU  - Messing, Albee
T1  - Conditional ablation of cerebellar astrocytes in postnatal transgenic mice.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/11//
VL  - 16
IS  - 21
SP  - 6908
EP  - 6918
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Delaney, Catherine L., School of Veterinary Medicine, 2015 Linden Drive West, Madison, WI, US, 53706
N1  - Accession Number: 2015-38437-027. PMID: 8824329 Partial author list: First Author & Affiliation: Delaney, Catherine L.; Neuroscience Training Program, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Messing, Albee. Major Descriptor: Cerebellum; Drug Therapy; N-Methyl-D-Aspartate; Neural Receptors; Granule Cells. Minor Descriptor: Mice; Astrocytes. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Nov, 1996. Publication History: Accepted Date: Aug 15, 1996; Revised Date: Aug 7, 1996; First Submitted Date: May 9, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - Astrocytes have been proposed to have multiple roles in the development and maintenance of the vertebrate CNS. To facilitate documentation of these roles, we designed a transgene to enable their ablation at selectable times. The transgene consists of the coding region for the herpes simplex virus-thymidine kinase (HSV-TK) under the control of the human glial fibrillary acidic protein gene promoter. The HSV-TK is innocuous but converts the antiherpetic agent ganciclovir (GCV) to a toxic product that interferes with DNA replication in proliferating cells. In a developmental study, transgenic mice were treated with GCV during the first postnatal week, with evaluation at P19. Treated mice displayed severe ataxia. Histological examination revealed disrupted astrocyte development, particularly in the cerebellum, with marked secondary effects on other cell types. Cerebellar defects included a loss in the numbers of astrocytes and an overall reduction in cerebellar size and disruption of the normally well defined cellular layers. Radial glia were disordered, Purkinje cells were ectopically distributed and displayed abnormal dendritic trees, and granule cells were markedly depleted. These effects were more severe in animals treated on postnatal day 1 versus treatment at day 5. A major factor causing granule cell death was excitotoxicity attributable to activation of NMDA receptors. These results suggest a critical role for astrocytes in cerebellar development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - astrocyte
KW  - cerebellum
KW  - development
KW  - glial fibrillary acidic protein
KW  - herpes simplex virus-thymidine kinase
KW  - transgenic
KW  - 1996
KW  - Cerebellum
KW  - Drug Therapy
KW  - N-Methyl-D-Aspartate
KW  - Neural Receptors
KW  - Granule Cells
KW  - Mice
KW  - Astrocytes
KW  - 1996
U1  - Sponsor: National Multiple Sclerosis Society. Grant: RG 2487-A1. Recipients: Messing, Albee
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38437-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-38438-017
AN  - 2015-38438-017
AU  - Liu, Maywin
AU  - Max, Mitchell B.
AU  - Parada, Suzan
AU  - Rowan, Janet S.
AU  - Bennett, Gary J.
T1  - The sympathetic nervous system contributes to capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia in humans.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1996/11//
VL  - 16
IS  - 22
SP  - 7331
EP  - 7335
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Max, Mitchell B., National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3C-405, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-38438-017. PMID: 8929439 Partial author list: First Author & Affiliation: Liu, Maywin; Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Capsaicin; Drug Therapy; Sympathetic Nervous System. Minor Descriptor: Placebo; Neuropathic Pain. Classification: Psychopharmacology (2580). Population: Human (10). Tests & Measures: Visual Analogue Scale. Methodology: Empirical Study; Quantitative Study. Page Count: 5. Issue Publication Date: Nov, 1996. Publication History: Accepted Date: Aug 29, 1996; Revised Date: Aug 19, 1996; First Submitted Date: Jun 10, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - The contribution of the sympathetic nervous system (SNS) to pain, mechanical allodynia (MA), and hyperalgesia in humans is controversial. A clearer understanding is crucial to guide therapeutic use of sympatholytic surgery, blocks, and drug treatments. In rats, capsaicin-evoked MA, and to some extent, pinprick hyperalgesia (PPH), can be blocked with α-adrenoreceptor antagonists. In this study, we examined the contribution of the SNS to MA and PPH in normal human subjects by blocking α-adrenoreceptors with intravenous phentolamine. In a double-blinded, placebo-controlled, crossover study, subjects were given IV saline or phentolamine, 1 mg/kg over 20 min. Ten minutes after the start of the infusion, subjects received 100 μg of intradermal capsaicin on the foot dorsum with the temperature of the injected site clamped at 36°C. The temperature of the uninjected foot was used to monitor the degree of α-adrenoreceptor blockade produced by phentolamine. Ongoing pain and MA and PPH areas were measured every 5 min for 60 min. A significantly greater increase in temperature on the uninjected foot was seen during the phentolamine infusion compared with the saline infusion, indicating α-adrenergic blockade. Significantly less MA was observed with the phentolamine infusion 10–25 min after capsaicin injection than with the saline infusion. No significant differences in ongoing pain or PPH areas were seen between the two infusions at any time. Our results suggest that capsaicin-evoked MA and PPH have different mechanisms, with the SNS having a role in MA but not in PPH or ongoing pain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - sympathetic nervous system
KW  - mechanical allodynia
KW  - mechanical hyperalgesia
KW  - capsaicin
KW  - phentolamine
KW  - pain
KW  - 1996
KW  - Capsaicin
KW  - Drug Therapy
KW  - Sympathetic Nervous System
KW  - Placebo
KW  - Neuropathic Pain
KW  - 1996
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-38438-017&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105855008
T1  - Recent trends in U.S. breast cancer incidence, survival, and mortality rates.
AU  - Chu KC
AU  - Tarone RE
AU  - Kessler LG
AU  - Ries LA
AU  - Hankey BF
AU  - Miller BA
AU  - Edwards BK
Y1  - 1996/11/06/
N1  - Accession Number: 105855008. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Epidemiology
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Breast Neoplasms -- Diagnosis
KW  - Breast Neoplasms -- Mortality
KW  - Breast Neoplasms -- Prevention and Control
KW  - Breast Neoplasms -- Therapy
KW  - Female
KW  - Health Screening
KW  - Incidence
KW  - Mammography
KW  - Middle Age
KW  - Survival -- Trends
KW  - United States
SP  - 1571
EP  - 1579
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 21
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Special Population Studies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 8901855.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105855008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107278162
T1  - A toxoid vaccine for pertussis as well as diphtheria? Lessons to be relearned.
AU  - Schneerson R
AU  - Robbins JB
AU  - Taranger J
AU  - Lagergard T
AU  - Trollfors B
Y1  - 1996/11/09/
N1  - Accession Number: 107278162. Language: English. Entry Date: 20090508. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - Pertussis Vaccine
KW  - Toxoids
KW  - Diphtheria Toxoid
KW  - Diphtheria -- Prevention and Control
KW  - Whooping Cough -- Prevention and Control
KW  - Immunization
KW  - Infant
KW  - Child
KW  - Adult
SP  - 1289
EP  - 1292
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 348 North American Edition
IS  - 9037
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, NIH, Room 424, Building 6, Bethesda, MD 20892
U2  - PMID: 8909384.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107278162&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107316080
T1  - Evaluation of methods for preparing and thawing cryopreserved CD34+ and CD34- cell lines for use as reagents in flow cytometry of hematopoietic progenitor cells.
AU  - Bowman CA
AU  - Yu M
AU  - Cottler-Fox M
Y1  - 1996/11/12/
N1  - Accession Number: 107316080. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - Flow Cytometry
KW  - Freezing -- Methods
KW  - Indicators and Reagents
KW  - Tissue Preservation -- Methods
KW  - Antigens
KW  - Antigens -- Analysis
KW  - Tissue Culture Techniques
KW  - Quality Assurance
KW  - Cryoprotective Agents -- Pharmacodynamics
KW  - Comparative Studies
KW  - Analysis of Variance
KW  - Statistical Significance
KW  - Descriptive Statistics
KW  - Human
SP  - 985
EP  - 988
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 36
IS  - 11/12
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8937409.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107316080&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Chiron, Marielle F.
AU  - Ogata, Masato
AU  - FitzGerald, David J.
T1  - Pseudomonas exotoxin exhibits increased sensitivity to furin when sequences at the cleavage site are mutated to resemble the arginine-rich loop of diphtheria toxin.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1996/11/15/
VL  - 22
IS  - 4
M3  - Article
SP  - 769
EP  - 778
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - To be toxic for mammalian cells, <em>Pseudomonas</em> exotoxin (PE) requires proteolytic cleavage between Arg-279 and Gly-280. Cleavage, which is mediated by the cellular protease furin, generates an active C-terminal fragment which translocates to the cytosol and inhibits protein synthesis. <em>In vitro</em>, furin-mediated cleavage is optimal at pH 5.5 with a relatively slow turnover rate. Within cells, only 5-10% of cell-associated PE is cleaved. To investigate the reasons for this inefficient cleavage, the amino acid composition near the cleavage site was altered to resemble more closely the arginine-rich sequence from the functionally similar region of diphtheria toxin (DT). Four PE-DT mutants were generated, whereby 1, 5, 6 or 8 amino acids at the PE-cleavage site were changed to amino acids found at the DT-cleavage site. Mutant proteins were expressed in <em>Escherichia coli</em>, purified and then analysed for their susceptibility to cleavage by furin and trypsin, susceptibility to cell-mediated cleavage, and cytotoxic activity relative to wild-type PE. At pH 5.5, the rate of both furin-mediated cleavage and trypsin-mediated cleavage increased dramatically when amino acids in PE were altered to resemble the DT sequence. This increase did not alter the pH optimum for furin-mediated cleavage of PE toxins, which remained at pH 5.0-5.5. When radioactive versions of selected PE-DT proteins were added to intact cells, an Increase in the percentage of molecules that were cleaved relative to wild-type PE was also seen. However, changes that favoured increased proteolysis apparently interfered with other important toxin functions because none of the PE-DT proteins exhibited enhanced toxicity for cells when compared with the activity of wild-type PE. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mammals
KW  - Toxins
KW  - Proteolytic enzymes
KW  - Bacterial toxins
KW  - Escherichia coli
KW  - Cells
KW  - Protein synthesis
KW  - Cytosol
N1  - Accession Number: 21342241; Chiron, Marielle F. 1; Ogata, Masato 1; FitzGerald, David J.; Affiliations: 1: Biotherapy Section, Laboratory of Molecular Biology, Division of Basic Science, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, 4B03 Bethesda, Maryland 20892, USA; Issue Info: Nov1996, Vol. 22 Issue 4, p769; Thesaurus Term: Mammals; Thesaurus Term: Toxins; Thesaurus Term: Proteolytic enzymes; Thesaurus Term: Bacterial toxins; Thesaurus Term: Escherichia coli; Subject Term: Cells; Subject Term: Protein synthesis; Subject Term: Cytosol; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 2 Diagrams, 3 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105855022
T1  - Development of cancer immunotherapies based on identification of the genes encoding cancer regression antigens.
AU  - Rosenberg SA
Y1  - 1996/11/20/
N1  - Accession Number: 105855022. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antigens, Tumor
KW  - Genes
KW  - Immunization -- Methods
KW  - Neoplasms -- Immunology
KW  - Neoplasms -- Therapy
KW  - Neoplasms
KW  - Animals
KW  - Kidney Neoplasms -- Therapy
KW  - Lymphocytes
KW  - Melanoma -- Therapy
SP  - 1635
EP  - 1644
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 22
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 8931607.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105855022&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105855030
T1  - Changing trends in U.S. prostate cancer incidence rates.
AU  - Merrill RM
AU  - Potosky AL
AU  - Feuer EJ
Y1  - 1996/11/20/
N1  - Accession Number: 105855030. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Prostatic Neoplasms -- Epidemiology
KW  - Aged
KW  - Aged, 80 and Over
KW  - Blacks -- Statistics and Numerical Data
KW  - Demography
KW  - Incidence
KW  - Male
KW  - Middle Age
KW  - Morbidity -- Trends
KW  - Prostatic Neoplasms -- Ethnology
KW  - Registries, Disease
KW  - United States
KW  - Whites -- Statistics and Numerical Data
SP  - 1683
EP  - 1685
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 22
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Applied Research Branch, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 8931614.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105855030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104792906
T1  - Gender differences in the risk of alcohol dependence: United States, 1992.
AU  - Dawson, D
Y1  - 1996/12//
N1  - Accession Number: 104792906. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcoholism -- Epidemiology
KW  - Adolescence
KW  - Adult
KW  - Age Factors
KW  - Alcoholism -- Diagnosis
KW  - Alcoholism -- Psychosocial Factors
KW  - Female
KW  - Human
KW  - Prospective Studies
KW  - Male
KW  - Middle Age
KW  - Psychological Tests
KW  - Relative Risk
KW  - Sex Factors
KW  - United States
SP  - 1831
EP  - 1842
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 91
IS  - 12
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Data from a representative sample of US adults revealed that 24% of male life-time drinkers and 15% of female life-time drinkers met the DSM-IV criteria for life-time alcohol dependence, i.e. dependence during the year preceding interview or in any 12-month period prior to that year. The median interval from first drink to onset of dependence was 3.6 years for men and 3.0 years for women. After using survival techniques to adjust for potential gender differences in the exposure to risk of developing alcohol dependence, the cumulative conditional probability of having experienced onset of dependence was 35.1% for men and 24.6% for women. The conditional probability of onset of dependence was equal for men and women in the first year after initiation of drinking, about 30% higher for men in the period 1-4 years after the first drink, and about 45% higher for men thereafter. After using proportional hazards models to adjust for the effects of age cohort, race and ethnicity, family history of alcoholism and age at first drink, these period-specific risk ratios remained virtually unchanged. Including a measure of average daily ethanol intake during periods of heaviest consumption rendered most of the gender differences statistically insignificant, revealing a slight excess risk of female dependence within the first year after initiation of drinking among the heaviest drinkers and leaving an excess male risk of dependence mostly among individuals with average daily intakes of less than one ounce of ethanol. The results suggest that different frequencies of binge drinking might help to account for these remaining gender differences and that men's and women's relative risks of developing alcohol dependence may vary as a function of life cycle stage, with men's excess risk greatest in the college/young adult years.
SN  - 0965-2140
AD  - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA.
U2  - PMID: 8997764.
DO  - 10.1111/j.1360-0443.1996.tb03812.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104792906&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107254671
T1  - Alcohol research and social policy: an overview.
AU  - Gordis E
Y1  - 1996/12//
N1  - Accession Number: 107254671. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0365245. 
KW  - Public Policy
KW  - Science
KW  - Alcohol Drinking
KW  - Social Attitudes
KW  - Public Sector
KW  - Private Sector
KW  - Legislation
KW  - Adolescence
SP  - 208
EP  - 212
JO  - Alcohol Health & Research World
JF  - Alcohol Health & Research World
JA  - ALCOHOL HEALTH RES WORLD
VL  - 20
IS  - 4
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - Science can facilitate the task of choosing among complex social policies, although it rarely serves as the only basis for policy development. Science's role in policy formation can be decisive when public support already exists, as with the passage of the Federal Uniform Drinking Age Act. Science can assess a policy after it has been implemented, as in the scientific evaluation of the health warning labels on alcoholic beverage containers. In addition, science can investigate the short- and long-term benefits and risks of areas where the development of policies is likely. An example is the current scientific examination of the tradeoffs involved in moderate alcohol consumption.
SN  - 0090-838X
AD  - Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107254671&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107312233
T1  - Differences in body composition of black and white girls.
AU  - Yanovski JA
AU  - Yanovski SZ
AU  - Filmer KM
AU  - Hubbard VS
AU  - Avila N
AU  - Lewis B
AU  - Reynolds JC
AU  - Flood M
Y1  - 1996/12//
N1  - Accession Number: 107312233. Language: English. Entry Date: 19970201. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Body Composition
KW  - Blacks
KW  - Whites
KW  - Genetics
KW  - Race Factors
KW  - Abdomen
KW  - Absorptiometry, Photon
KW  - Body Weight
KW  - Body Mass Index
KW  - Magnetic Resonance Imaging
KW  - Adipose Tissue -- Analysis
KW  - Comparative Studies
KW  - Descriptive Statistics
KW  - Analysis of Variance
KW  - Data Analysis Software
KW  - Fisher's Exact Test
KW  - Regression
KW  - Child
KW  - Female
KW  - Human
SP  - 833
EP  - 839
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 64
IS  - 6
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Adults have racial differences in body composition that may modulate risks resulting from obesity. Although black and white children have been shown previously to have differences in bone mineral density and subcutaneous body fat, differences in visceral adipose tissue have not been evaluated. We studied 20 black and 20 white normal-weight girls aged 7-10 y, who were matched for weight, body mass index (BMI), bone age, chronological age, Tanner breast stage, and socioeconomic status. Each underwent anthropometric measurements, bioelectrical impedance analysis, dual-energy X-ray absorptiometry (DXA), and abdominal magnetic resonance imaging (MRI) for determination of total (TAT), visceral (VAT), and subcutaneous (SAT) adipose tissue. Serum lipids and fasting and 2-h oral-glucose-tolerance test (OGTT) glucose and insulin concentrations were also measured. There were no differences between groups in absolute waist circumference or waist-to-hip ratio, but waist-to-thigh ratio was smaller in black than in white girls. Black girls had greater bone mineral density and less TAT, VAT, and SAT than whites. VAT was not significantly correlated with any measure of insulin, or with serum lipids. However, both basal and 2-h OGTT serum insulin were significantly correlated with SAT as assessed by MRI in black girls (r2 = 0.46 for basal insulin, P = 0.001; r2 = 0.31 for 2-h insulin, P = 0.01) but not in white girls (r2 < 0.05, for basal and 2-h insulin, NS). We conclude that there are significant racial differences in body composition and differences in the strength of association between abdominal adipose tissue depots and insulin sensitivity in black and white girls. (c) 1996 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Institutes of Health MSC 1862, Building 10 Room 10N262, 9000 Rockville Pike, Bethesda, MD 20892-1862, E-mail; jy15i@nih.gov
U2  - PMID: 8942404.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107312233&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107312246
T1  - Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feedings study.
AU  - Dorgan JF
AU  - Judd JT
AU  - Longcope C
AU  - Brown C
AU  - Schatzkin A
AU  - Clevidence BA
AU  - Campbell WS
AU  - Nair PP
AU  - Franz C
AU  - Kahle L
AU  - Taylor PR
Y1  - 1996/12//
N1  - Accession Number: 107312246. Language: English. Entry Date: 19970201. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Dietary Fats -- Pharmacodynamics
KW  - Dietary Fiber -- Pharmacodynamics
KW  - Androgens
KW  - Estrogens
KW  - Androgens -- Analysis
KW  - Estrogens -- Analysis
KW  - Blood -- Analysis
KW  - Urinalysis
KW  - Radioimmunoassay
KW  - Crossover Design
KW  - Data Analysis Software
KW  - T-Tests
KW  - Wilcoxon Rank Sum Test
KW  - Confidence Intervals
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Human
SP  - 850
EP  - 855
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 64
IS  - 6
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - We conducted a controlled feeding study to evaluate the effects of fat and fiber consumption on plasma and urine sex hormones in men. The study had a crossover design and included 43 healthy men aged 19-56 y. Men were initially randomly assigned to either a low-fat, high-fiber or high-fat, low-fiber diet for 10 wk and after a 2-wk washout period crossed over to the other diet. The energy content of diets was varied to maintain constant body weight but averaged approximatly 13.3 MJ (3170 kcal)/d on both diets. The low-fat diet provided 18.8% of energy from fat with a ratio of polyunsaturated to saturated fat (P:S) of 1.3, whereas the high-fat diet provided 41.0% of energy from fat with a P:S of 0.6. Total dietary fiber consumption from the low- and high-fat diets averaged 4.6 and 2.0 g x MJ-1 x d-1, respectively. Mean plasma concentrations of total and sex-hormone-binding globulin (SHBG)-bound testosterone were 13% and 15% higher, respectively, on the high-fat, low-fiber diet and the difference from the low-fat, high-fiber diet was significant for the SHBG-bound fraction (P = 0.04). Men's daily urinary excretion of testosterone also was 13% higher with the high-fat, low-fiber diet than with the low-fat, high-fiber diet (P = 0.01). Conversely, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were 12-28% lower with the high-fat, low-fiber diet (P = 0.01). Results of this study suggest that diet may alter endogenous sex hormone metabolism in men. (c) 1996 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Cancer Institute, Executive Plaza North, Room 211, 6130 Executive Boulevard, Bethesda, MD 20892-7326, E-mail: dorganj@dcpcepn.nci.nih.gov
U2  - PMID: 8942407.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
AU  - Young, L. R.;
AU  - Masucci, I. P.;
T1  - Algorithm for managing compatibility of parenteral medications
CT  - Algorithm for managing compatibility of parenteral medications
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - P
EP  - D
AD  - National Institutes of Health, Building 10, Room 1N-257, Bethesda, MD 20892, USA
N1  - Accession Number: 33-13560; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Drug Stability; Institutional Pharmacy Practice
N2  - Several specialized resources on compatibility of injectable drugs are widely available and readily accessible to most pharmacists. While such resources contain valuable information regarding the compatibility of specific medications, they do not provide pharmacists with a consistent approach for promptly and effectively resolving drug compatibility issues. Furthermore, such resources do not offer alternatives when incompatibilities exist or when compatibility data are unavailable. Ineffective management of drug compatibility issues can compromise the quality of patient care. Our goal is to develop an algorithm that can provide pharmacists with a tool to systematically evaluate compatibility information and effectively manage the administration of parenteral medications. The algorithm will address pertinent drug, device, and patient factors that pharmacists should routinely consider. It will also identify options that should be evaluated when incompatibilities are encountered or hen compatibility information is limited or unavailable.
KW  - Practice Interest Areas--Intravenous Therapy/Infusion Devices--meeting presentations;
KW  - ASHP meeting abstracts--algorithms, incompatibilities;
KW  - Protocols--algorithms--incompatibilities;
KW  - Stability--injections--algorithms;
KW  - Incompatibilities--injections--algorithms;
KW  - Injections--stability--algorithms;
KW  - Additives--injections--incompatibilities;
KW  - Storage--injections--stability;
KW  - Administration--hospital pharmacy--incompatibility algorithms;
KW  - Pharmacy, institutional, hospital--administration--incompatibility algorithms;
KW  - Pharmacy services--incompatibilities--algorithms;
KW  - Pharmacists, hospital--role--incompatibility management;
KW  - Devices--injections--incompatibility algorithms;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=33-13560&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Byrd, D. C.;
AU  - Boumpas, D.;
AU  - Piscitelli, S. C.;
AU  - Pucino, F.;
AU  - Yarboro, C.;
T1  - Pharmacokinetics and pharmacodynamics of intermittent intravenous fludarabine in psoriatic arthritis patients
CT  - Pharmacokinetics and pharmacodynamics of intermittent intravenous fludarabine in psoriatic arthritis patients
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - P
EP  - R
AD  - National Institutes of Health, Building 10, Room 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 33-13637; Language: English; Chemical Name: Fludarabine--21679-14-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents fludarabine; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Pharmacology
N2  - Study objective is to characterize the pharmacokinetics and pharmacodynamics of fludarabine in psoriatic arthritis. Ten psoriatic arthritis patients will receive intravenous fludarabine 30 mg/sq m/day over 30 minutes for two to three days (total of four cycles). Nine serum samples (before first and second dose, 0.5, 1, 2, 4, 8, 24, and 48 hours after second dose) and four urine samples (before first and second dose and from two consecutive 24 hour urine collections after the second dose) will be drawn during the first two cycles of treatment for determination of fludarabine concentrations, via HPLC analysis. Parameters to be assessed include Vdss, Cl, T1/2, Cmax, AUC, and percent urinary drug recovery. Relationships between drug exposure and changes in disease activity and selected lymphocytes will also be evaluated.
KW  - Fludarabine--pharmacokinetics-;
KW  - Practice Interest Areas--Clinical Pharmacokinetics--meeting presentations;
KW  - ASHP meeting abstracts--fludarabine pharmacokinetics;
KW  - Pharmacokinetics--fludarabine--psoriatic arthritis;
KW  - Pharmacodynamics--fludarabine--psoriatic arthritis;
KW  - Blood levels--fludarabine--pharmacokinetics;
KW  - Urine levels--fludarabine--pharmacokinetics;
KW  - Arthritis--fludarabine--psoriatic;
KW  - Antineoplastic agents--fludarabine--pharmacokinetics;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=33-13637&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Jarosinski, P. F.;
T1  - Immune-based therapeutics: HIV vaccines
CT  - Immune-based therapeutics: HIV vaccines
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - PI
EP  - 94
AD  - National Institutes of Health, 10 Center Drive, MSC 1196, Bethesda, MD 20892, USA
N1  - Accession Number: 33-13604; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - There is an urgent need to control the epidemic of human immunodeficiency virus type 1 (HIV-1) infection. While modification of risk-taking behavior is capable of reducing the spread of HIV-1 infection, it is unlikely that this modification alone will result in eradication of the disease. Vaccine mechanisms of prevention or modification of HIV-1 disease would be an important advance in controlling the disease. Vaccine development for HIV-1 infection, however, has been difficult due to the unique characteristics of the HIV-1 virus. Over 20 vaccines have been developed for clinical trials; however, a vaccine suitable for use in the general public is still some time away. Learning objectives: 1. Describe some of the unique challenges of the HIV-1 virus related to vaccine development. 2. List the goals of HIV-1 vaccine development. 3. Identify some accomplishments of HIV-1 vaccine development to date. Self-assessment questions: True or False: 1. Lack of a good animal model for HIV disease is an impediment to vaccine development. 2. While an effective HIV-1 vaccine could prevent clinical disease, it offers little hope for those already affected. 3. Phase I and II studies to date have caused no harm to patients enrolled. Answers: 1. T; 2. F; 3. T.
KW  - AIDS vaccines--research-;
KW  - ASHP meeting abstracts--immune based therapeutics;
KW  - Vaccines--acquired immunodeficiency syndrome--product development;
KW  - Research--AIDS vaccines--immune based therapeutics;
KW  - Immunotherapy--HIV infections--AIDS vaccines;
KW  - Toxicity--AIDS vaccines--research;
KW  - HIV infections--AIDS vaccines--immune based therapeutics;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=33-13604&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Piscitelli, S. C.;
T1  - Immune-based therapies: rationale and novel approaches for managing HIV infection
CT  - Immune-based therapies: rationale and novel approaches for managing HIV infection
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - PI
EP  - 92
AD  - Pharmacy Department, National Institutes of Health, Building 10, Room 1N257, Bethesda, MD 20892, USA
N1  - Accession Number: 33-13605; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - Current therapies for HIV infection are limited by unknown long-term efficacy, overlapping toxicities, and the development of resistance. A variety of immune-based therapies are currently under investigation. These agents act to enhance, boost, or augment the patient's weakened immune system. Immune reconstitution, gene therapy, cytokine replacement, and inhibition of pro-inflammatory cytokines are all examples of immune-based therapeutics currently in clinical trials. Investigation of these immunologic approaches to therapy may lead to important new strategies for the treatment of HIV infection. Learning objectives: 1. Discuss the rationale for the use of immune-based therapies in HIV infection. 2. Describe the process and results of adoptive transfer of T-cells. 3. Identify agents which are inhibitors of pro-inflammatory cytokines. 4. Discuss the progress of gene therapy research for HIV infection. Self-assessment questions: True or False: 1. HIV is a latent infection between the time of initial exposure and onset of clinical symptoms. 2. Thalidomide is an effective agent for HIV-associated aphthous ulcers. 3. The primary cellular target of gene therapy approaches is the CD4 cell. Answers: 1. F; 2. T; 3. T.
KW  - ASHP meeting abstracts--immune based therapeutics;
KW  - Immunotherapy--HIV infections;
KW  - Gene therapy--HIV infections;
KW  - Cytokines--HIV infections--immune based therapeutics;
KW  - HIV infections--immunotherapy--immune based therapeutics;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=33-13605&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
T1  - Importance of trial design to application of information
CT  - Importance of trial design to application of information
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - PI
EP  - 30
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1N-257, 10 Center Drive, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 33-13658; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Methodology
N2  - The design of a study is one of the most critical elements in determining its success. An optimal study design must be selected so that a research question can be adequately answered. Properly designed clinical trials are generally regarded as the most definitive and rigorous of study designs. Clinical trials must incorporate appropriate control groups so that valid comparisons can be made. Effective use of randomization and blinding techniques is also essential. The ability to apply information from clinical trials in daily practice is largely dependent on the quality and integrity of the study methodology. Critical evaluation of study designs and methods is important in determining a study's internal and external validity. Learning objectives: 1. List the major types of study designs. 2. Describe the advantages and disadvantages of experimental research designs. 3. List the most common flaws detected in published clinical studies. Self-assessment questions: True or False: 1. Inadvertent biases can be introduced in randomization and masking. 2. Flaws in study design always lead to data that is not valid. 3. Generalizability of results from clinical trials depends largely on the study methods. Answers: 1. T; 2. F; 3. T.
KW  - ASHP meeting abstracts--clinical study design;
KW  - Methodology--clinical studies--validation;
KW  - Clinical studies--methodology--validation;
KW  - Control, quality--validation--clinical studies;
KW  - Research--clinical studies--design;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Kovacs, J. A.;
T1  - Interleukins and interferons as therapeutic agents in HIV infection
CT  - Interleukins and interferons as therapeutic agents in HIV infection
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - PI
EP  - 93
AD  - Critical Care Medicine Department, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA
N1  - Accession Number: 33-13606; Language: English; Chemical Name: Interleukin 2--102524-44-7; Therapeutic Class: (8:18); AHFS Class: Antivirals \a/-interferon; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - HIV infection is associated with a profound alteration in cytokine regulation and function. Clinical studies have shown that therapy with interleukin-2 can lead to sustained increases in CD4 counts in HIV-infected patients, primarily those with some degree of preserved immunocompetence. Other cytokines, such as interferon-\a/, have shown promise as therapeutic modalities for treatment of Kaposi's sarcoma. However, many issues remain unresolved including the potential for viral activation, attenuation of adverse effects, and optimal dosage and duration of therapy. Learning objectives: 1. Discuss the rationale for the use of interleukin-2 therapy for HIV infection. 2. Identify the manifestations of HIV disease where interferon-\a/ is an effective therapy. 3. Describe the adverse effect profiles of recombinant cytokines. Self-assessment questions: True or False: 1. Interleukin-2 therapy can give rise to sustained increases in CD4 counts in HIV-infected patients. 2. Flu-like syndrome is a common side effect of both interferon-\a/ and interleukin-2. 3. Interleukin-2 has a potent antiretroviral effect. Answers: 1. T; 2. T; 3. F.
KW  - \a/-Interferon--HIV infections-;
KW  - Interleukin 2--HIV infections-;
KW  - ASHP meeting abstracts--immune based therapeutics;
KW  - Immunotherapy--interleukin 2--HIV infections;
KW  - Antivirals--\a/-interferon--HIV infections;
KW  - HIV infections--\a/-interferon--immune based therapeutics;
KW  - HIV infections--interleukin 2--immune based therapeutics;
KW  - Interferons--HIV infections--immune based therapeutics;
KW  - Interleukins--HIV infections--immune based therapeutics;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goldspiel, B. R.;
T1  - Vaccines as therapeutic agents: new frontier
CT  - Vaccines as therapeutic agents: new frontier
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1996/12/01/
VL  - 31
IS  - Dec
SP  - PI
EP  - 29
AD  - Pharmacy Department, NIH Clinical Center, Building 10, Room 1N-257, Bethesda, MD 20892-1196, USA Internet: bgoldspiel@nih.gov
N1  - Accession Number: 33-13396; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Investigational Drugs; Pharmacology
N2  - The immune system can be a powerful weapon against diseases including cancer and HIV infection. The discovery of tumor specific antigens has led to a renewed interest in the development of various vaccination approaches for cancer treatment. Vaccine research for cancer includes peptide pulsing, injecting DNA plasmids, and inserting genes into various viral vectors. The best hope for preventing the spread of HIV infection rests with the development of a safe and effective vaccine. Clinical trials of candidate HIV vaccines have begun. In this regard both recombinant envelope proteins and recombinant vaccinia viruses expressing HIV envelope have been demonstrated to be safe and immunogenic in healthy uninfected volunteers and some of these vaccines are also being tested as forms of active immunotherapy in patients who are already HIV-infected. This talk will summarize the current therapeutic applications of vaccines for cancer and HIV infection. Learning objectives: 1. Discuss the immunologic mechanisms that are important to understand vaccine development and action. 2. Outline the history of cancer vaccine development. 3. Discuss the advantages and disadvantages of using various virus vectors for tumor-associated antigens. 4. List the strategies for HIV vaccine development. Self-assessment questions: 1. True or False: Tumor cells have been shown to express unique antigens. 2. B7 is a: a. Tumor specific antigen; b. Class I MHC molecule; c. Costimulatory molecule; d. Neutralizing antibody. 3. Cancer vaccines may be administered: a. by scarification; b. subcutaneously; c. intramuscularly; d. all of the above are correct. Answers: 1. T; 2. c; 3. d.
KW  - Neoplasm vaccines--research-;
KW  - AIDS vaccines--research-;
KW  - ASHP meeting abstracts--AIDS, neoplasm vaccines;
KW  - Immunization--HIV infections--research;
KW  - Immunization--neoplasms--research;
KW  - Research--vaccines--AIDS, neoplasm;
KW  - HIV infections--immunization--research;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
AU  - Hershkowitz, Irit
AU  - Sternberg, Kathleen J.
AU  - Boat, Barbara
AU  - Everson, Mark D.
T1  - INVESTIGATIVE INTERVIEWS OF ALLEGED SEXUAL ABUSE VICTIMS WITH AND WITHOUT ANATOMICAL DOLLS.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1996/12//
VL  - 20
IS  - 12
M3  - Article
SP  - 1251
EP  - 1259
SN  - 01452134
AB  - Verbal and nonverbal responses by alleged victims of child sexual abuse were coded for length, amount of information, and the manner in which they were elicited by the interviewer. In 16 of the interviews, anatomical dolls were employed for the purposes of demonstration, whereas they were not used in another eight cases matched with respect to other characteristics of the children and the alleged events. Children interviewed with dolls provided an equivalent number of details and spoke as many words in the substantive portion of the interview as did children interviewed without dolls, and interviewers in the two groups used similar probes to elicit information. However, the average responses by the children were significantly longer and more detailed when dolls were not used. Children gave longer and more detailed responses to open-ended invitations when dolls were not used. Caution is necessary when interpreting these findings. (English) [ABSTRACT FROM AUTHOR]
AB  - Las respuestas verbales y no verbales de supuestas víctimas de abuso sexual contra los niños fueron codificadas en duración, cantidad de información y la manera en que fueron obtenidas por el entrevistador. En 16 de las entrevistas, se utilizaron para demostración las muñecas anatómicas, ya que no fueron usadas en otros 8 casos apareados en relación a otras características de los niños y los supuestos eventos. Los niños entrevistados con muñecas ofrecieron un número equivalente de detalles y dijeron el mismo número de palabras en la porción sustantiva de la entrevista como los niños entrevistados sin muñecas, y los entrevistadores en los dos grupos utilizaron estrategias similares para obtener la información. Sin embargo, las respuestas promedio de los niños fueron significativamente mayores y más detalladas cuando no se utilizaron muñecas. Los niños dieron respuestas más largas y detalladas a preguntas de final abierto cuando no se usaban las muñecas. Es necesario interpretar estos resultados con cautela. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Les réponses verbales et non verbales d'enfants supposés victimes d'abus sexuels ont été codées par un interrogateur pour la longueur, la quantité d'information et la manière dont elles ont été obtenues. Dans 16 de ces anamnèses des poupees anatomiques ont été employées dans un but de démonstration alors qu'elles ne l'ont pas été dans 8 autres cas appariés pour toutes les autres caractéristiques des enfants comme des événements supposés. Les enfants interrogés è l'aide des poupées ont fourni un nombre équivalent de détails et ont exprimé autant de mots au cours de la partie centrale de l'anamnèse que les enfants interrogés sans les poupées, et les interrogateurs des deux groupes ont utilisé les mêmes coups de sonde pour obtenir les informations. En moyenne cependant, les réponses des enfants étaient significativement plus longues et plus élaborées quand les poupées n'étaient pas utilisées. Les enfants ont donné des réponses plus longues et détaillées aux incitations ouvertes lorsque les poupées n'étaient pas utilisées. Il est nécessaire d'observer ces observations avec prudence. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD sexual abuse
KW  - CHILD abuse
KW  - SEXUALLY abused children
KW  - INTERVIEWING in child abuse
KW  - DOLLS
KW  - ANATOMICAL dolls
KW  - Anatomical dolls
KW  - Interview processes
KW  - Investigative interviews
N1  - Accession Number: 9703066618; Lamb, Michael E. 1 Hershkowitz, Irit 1 Sternberg, Kathleen J. 1 Boat, Barbara 1 Everson, Mark D. 2; Affiliation:  1: Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA  2: Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, USA; Source Info: Dec96, Vol. 20 Issue 12, p1251; Subject Term: CHILD sexual abuse; Subject Term: CHILD abuse; Subject Term: SEXUALLY abused children; Subject Term: INTERVIEWING in child abuse; Subject Term: DOLLS; Subject Term: ANATOMICAL dolls; Author-Supplied Keyword: Anatomical dolls; Author-Supplied Keyword: Interview processes; Author-Supplied Keyword: Investigative interviews; NAICS/Industry Codes: 339930 Doll, Toy, and Game Manufacturing; NAICS/Industry Codes: 414460 Toy and hobby goods merchant wholesalers; NAICS/Industry Codes: 423920 Toy and Hobby Goods and Supplies Merchant Wholesalers; Number of Pages: 9p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cooper, P. J.
AU  - Guderian, R. H.
AU  - Prakash, D.
AU  - Remick, D. G.
AU  - Espinel, I.
AU  - Nutman, T. B.
AU  - Taylor, D. W.
AU  - Griffin, G. E.
T1  - RANTES in onchocerciasis: changes with ivermectin treatment.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1996/12//
VL  - 106
IS  - 3
M3  - Article
SP  - 462
EP  - 467
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Adverse reactions are seen relatively frequently after treatment of onchocerciasis patients with ivermectin. The chemokines RANTES and lL-8, which have both chemotactic and activation properties for eosinophils and neutrophils, respectively, may have a role in the pathogenesis of post-treatment reactions. Circulating levels of the chemokines and the cytokines tumour necrosis factor-alpha (TNF-α) and IL-6 were measured in the plasma of 22 Onchocerca volvulus-infected subjects. Peaks of mean circulating levels of RANTES and TNF-a were seen at 6 h after ivermectin administration. Peripheral eosinophil counts declined at 36 h post-treatment and an early peak in RANTES levels was associated with a delay in peripheral eosinopenia. RANTES levels were negatively correlated with severity of rash (P < 0.001) and lymphoedema (P < 0.05), suggesting that high circulating levels of RANTES may inhibit eosinophil sequestration. No changes in circulating levels of IL-8 were seen. These findings suggest a possible role of circulating RANTES in modulating eosinophil sequestration in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ONCHOCERCIASIS
KW  - CYTOKINES
KW  - LEUCOCYTES
KW  - FILARIASIS
KW  - CELLULAR immunity
KW  - PEPTIDES
KW  - chemokines
KW  - cytokines
KW  - ivermectin
KW  - onchocerciasis
KW  - RANTES
N1  - Accession Number: 15892763; Cooper, P. J. 1 Guderian, R. H. 1 Prakash, D. 2 Remick, D. G. 2 Espinel, I. 3 Nutman, T. B. 4 Taylor, D. W. 5 Griffin, G. E. 3; Affiliation:  1: Onchocerciasis Control Programme, Hospital Vozandes, Quito, Ecuador.  2: Department of Pathology, University of Michigan Medical School, MI.  3: Division of Infectious Diseases, St George's Hospital Medical School, London, UK.  4: Laboratory of Parasitic Diseases, National Institutes of Health, MD, USA.  5: Centre for Tropical Veterinary Medicine, University of Edinburgh, Edinburgh, UK.; Source Info: Dec1996, Vol. 106 Issue 3, p462; Subject Term: ONCHOCERCIASIS; Subject Term: CYTOKINES; Subject Term: LEUCOCYTES; Subject Term: FILARIASIS; Subject Term: CELLULAR immunity; Subject Term: PEPTIDES; Author-Supplied Keyword: chemokines; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: ivermectin; Author-Supplied Keyword: onchocerciasis; Author-Supplied Keyword: RANTES; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - PRICE, CATHERINE J.
AU  - MARR, MELISSA C.
AU  - MYERS, CHRISTINA
AU  - SEELY, JOHN C.
AU  - HEINDEL, JERROLD J.
AU  - SCHWETZ, BERNARD A.
T1  - The Developmental Toxicity of Boric Acid in Rabbits1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/12//
VL  - 34
IS  - 2
M3  - Article
SP  - 176
EP  - 187
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Boric acid (BA), an ingredient of many pharmaceutical, cosmetic, and pesticide products, was previously shown to induce reproductive and developmental toxicity in laboratory rodents. In this study, BA (0, 62.5, 125, or 250 mg/kg/day, po) was administered on Gestational Days (GD) 6–19 to New Zealand White rabbits (18–23 pregnant/group). Maternal body weight, food consumption, and clinical condition were monitored at regular intervals throughout gestation. At termination (GD 30), the numbers of uterine implantations, resorptions, dead fetuses, and live fetuses were determined. Fetuses were weighed, and live fetuses examined for external, visceral, and skeletal defects. Maternal food intake decreased during treatment at 250 mg/kg/day and increased at ≥125 mg/kg/day after treatment. Maternal body weight (GD 9–30), weight gain during treatment, gravid uterine weight, and number of ovarian corpora lutea decreased at 250 mg/kg/day. In contrast, maternal corrected gestational weight gain increased at ≥125 mg/kg/day. Maternal liver weight was not affected. Relative (but not absolute) maternal kidney weight increased at 250 mg/kg/day, and microscopic evaluation revealed no treatment-related renal pathology. At 250 mg/kg/day, prenatal mortality was increased (90% resorptions/litter vs 6% for controls), the proportion of pregnant females with no live fetuses was increased (73% vs 0%), and live litter size was reduced (2.3 fetuses/litter vs 8.8). As a result, there were only 14 live fetuses (6 live litters) available for evaluation in the high-dose group, compared to 153–175 live fetuses (18–23 live litters) in the other groups. The percentage malformed fetuses/litter was increased at 250 mg/kg/day, primarily due to cardiovascular defects in 72% of high-dose fetuses vs 3% of controls. The most prevalent cardiovascular malformation (in terventricular septal defect) was observed in 57% of high-dose fetuses compared to 0.6% among controls. At 250 mg/kg/day, average fetal body weight/litter was 92% of the average control weight (not statistically significant). In summary, no definitive maternal or developmental toxicity was observed at 62.5 or 125 mg/kg/day BA. Mild maternal effects and severe developmental toxicity were observed at 250 mg/kg/day. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Boric acid
KW  - Rabbits as laboratory animals
KW  - Pregnancy in animals
KW  - Reproductive health
KW  - Developmental toxicology
N1  - Accession Number: 82415667; PRICE, CATHERINE J. 1; MARR, MELISSA C. 1; MYERS, CHRISTINA 1; SEELY, JOHN C. 2; HEINDEL, JERROLD J. 3; SCHWETZ, BERNARD A. 3; Affiliations: 1: Chemistry and Life Science, Center for Life Sciences and Toxicology, Research Triangle Institute P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194; 2: † PATHCO, Inc. P.O. Box 12796, Research Triangle Park, North Carolina 27709; 3: ‡ Developmental and Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; Issue Info: 1996, Vol. 34 Issue 2, p176; Subject Term: Boric acid; Subject Term: Rabbits as laboratory animals; Subject Term: Pregnancy in animals; Subject Term: Reproductive health; Subject Term: Developmental toxicology; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - GEORGE, JULIA D.
AU  - PRICE, CATHERINE J.
AU  - MARR, MELISSA C.
AU  - MYERS, CHRISTINA B.
AU  - SCHWETZ, BERNARD A.
AU  - HEINDEL, JERROLD J.
AU  - HUNTER, E. SIDNEY
T1  - Evaluation of the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats and New Zealand White Rabbits.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1996/12//
VL  - 34
IS  - 2
M3  - Article
SP  - 249
EP  - 259
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Timed-pregnant Sprague-Dawley (CD) outbred rats and New Zealand White rabbits were dosed by gavage with methacrylonitrile (MACR) in distilled water during major organogenesis. Rats were dosed on Gestational Days (GD) 6 through 15 (0, 5, 25, or 50 mg MACR/kg/day) and rabbits on GD 6 through 19 (0, 1, 3, or 5 mg MACR/kg/day). Maternal clinical status was monitored daily during treatment. At termination (GD 20, rats; GD 30, rabbits), confirmed-pregnant females (25–26 per group, rats; 17–22 per group, rabbits) were evaluated for clinical status and gestational outcome; each live fetus was examined for external, visceral, and skeletal malformations. In rats, no treatment-related maternal clinical signs or mortality were observed, nor was there any adverse effect on maternal body weight or food or water consumption. At necropsy, absolute, relative, and adjusted maternal liver weight was increased at the mid- and high-dose groups, an effect that may be indicative of induction of hepatic enzymes rather than toxicity. In the absence of any indication of maternal toxicity, the no-observed-adverse-effect level (NOAEL) for maternal toxicity in this study was ≥50 mg MACR/kg/day. The NOAEL for develop mental toxicity in rats was also ≥50 mg MACR/kg/day. There was no effect of treatment on postimplantation loss, mean fetal body weight per litter, or morphological development. In rabbits, maternal mortality and clinical signs were not dose related. Maternal food consumption, body weight, and liver weight were not adversely affected by treatment. Thus, the maternal NOAEL was ≥5 mg MACR/kg/day. Maternal toxicity, including death, was observed ≥7.5 mg/kg/day in preliminary studies. The developmental NOAEL was also ≥5 mg MACR/kg/day. There was no adverse effect of treatment on postimplantation loss or fetal body weight. A significant decrease in the percentage male fetuses per litter was observed, although there was no effect on total live litter size, suggesting that the reduction in the ratio of live male fetuses in the high-dose group was not biologically significant. MACR had no adverse effect on morphological development. In summary, oral administration of MACR to rats and rabbits during organogenesis, at doses that did not cause persistent maternal toxicity (50 mg MACR/kg/day, rats; 5 mg MACR/kg/day, rabbits), also did not cause any adverse developmental effects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxicity testing
KW  - Methacrylonitrile
KW  - Morphogenesis
KW  - Pregnancy in animals
KW  - Developmental toxicology
N1  - Accession Number: 82415673; GEORGE, JULIA D. 1; PRICE, CATHERINE J. 1; MARR, MELISSA C. 1; MYERS, CHRISTINA B. 1; SCHWETZ, BERNARD A. 2; HEINDEL, JERROLD J. 2; HUNTER, E. SIDNEY 2; Affiliations: 1: Chemistry and Life Sciences, Research Triangle Institute Post Office Box 12194, Research Triangle Park, North Carolina 27709-2194; 2: † Development and Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; Issue Info: 1996, Vol. 34 Issue 2, p249; Thesaurus Term: Toxicity testing; Thesaurus Term: Methacrylonitrile; Subject Term: Morphogenesis; Subject Term: Pregnancy in animals; Subject Term: Developmental toxicology; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Hann, Della M.
AU  - Osofsky, Joy D.
AU  - Culp, Anne M.
T1  - Relating the Adolescent Mother--Child Relationship to Preschool Outcomes.
JO  - Infant Mental Health Journal
JF  - Infant Mental Health Journal
Y1  - 1996///Winter96
VL  - 17
IS  - 4
M3  - Article
SP  - 302
EP  - 309
PB  - John Wiley & Sons, Inc.
SN  - 01639641
AB  - Two domains of potential risk in relation to the cognitive-linguistic outcomes of preschool children of adolescent mothers were investigated: (1) interactive features of the mother—child relationship and (2) aspects of the demographic context of parenting. Sixty-nine adolescent mothers and their children a participated in evaluation when the children were 13, 20, 30, and 44 months old. Results indicated that the cognitive-linguistic development of children of adolescent mothers was affected by both the mother—child relationship and cumulative index of demographic risk. Specifically, positive maternal affect, mother—child verbal reciprocity, mother—child interactive fit, and cumulative demographic risk all contributed to explaining difficulties in preschool cognitive and linguistic functioning in children of adolescent mothers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Infant Mental Health Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RISK assessment
KW  - PRESCHOOL children
KW  - MOTHER & child
KW  - PARENTING
KW  - MATERNAL love
KW  - TEENAGE mothers
KW  - CHILD rearing
KW  - MENTAL health
KW  - INTERPERSONAL relations
KW  - PSYCHOLOGY
KW  - CHILD development
N1  - Accession Number: 12038106; Hann, Della M. 1 Osofsky, Joy D. 2 Culp, Anne M. 3; Affiliation:  1: National Institute of Mental Health  2: Louisiana State University Medical Center  3: Oklahoma State University; Source Info: Winter96, Vol. 17 Issue 4, p302; Subject Term: RISK assessment; Subject Term: PRESCHOOL children; Subject Term: MOTHER & child; Subject Term: PARENTING; Subject Term: MATERNAL love; Subject Term: TEENAGE mothers; Subject Term: CHILD rearing; Subject Term: MENTAL health; Subject Term: INTERPERSONAL relations; Subject Term: PSYCHOLOGY; Subject Term: CHILD development; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107351691
T1  - Fever in the neutropenic host.
AU  - Chanock SJ
AU  - Pizzo PA
Y1  - 1996/12//1996 Dec
N1  - Accession Number: 107351691. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Neutropenia -- Complications
KW  - Neutropenia -- Etiology
KW  - Immunocompromised Host
KW  - Fever
KW  - Immunosuppressive Agents -- Adverse Effects
KW  - Patient Assessment
KW  - Neutropenia -- Drug Therapy
SP  - 777
EP  - 796
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 10
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0891-5520
AD  - National Cancer Institute, Bldg 10, Rm 13N240, Bethesda, Maryland 20892
U2  - PMID: 8958168.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107351691&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107339441
T1  - Family dynamics and children in medical research.
AU  - Gordon VM
AU  - Bonkovsky FO
Y1  - 1996///1996 Winter
N1  - Accession Number: 107339441. Language: English. Entry Date: 19971001. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9114645. 
KW  - Research Ethics
KW  - Research Subjects
KW  - Clinical Research
KW  - Consent
KW  - Family Functioning
KW  - Parents -- Psychosocial Factors
KW  - Minors (Legal)
KW  - Child
KW  - Ethics, Medical
KW  - Research Protocols
KW  - Family Relations
KW  - Decision Making, Ethical
KW  - Patient Rights -- In Infancy and Childhood
KW  - Adolescence
SP  - 349
EP  - 354
JO  - Journal of Clinical Ethics
JF  - Journal of Clinical Ethics
JA  - J CLIN ETHICS
VL  - 7
IS  - 4
CY  - Hagerstown, Maryland
PB  - University Publishing Group Inc.
SN  - 1046-7890
AD  - National Institutes of Health, Bethesda, MD
U2  - PMID: 9029336.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bale, Sherri J.
AU  - Russell, Laura J.
AU  - Lee, Minjoo L.
AU  - Compton, John G.
AU  - DiGiovanna, John J.
T1  - Congenital Recessive Ichthyosis Unlinked to Loci for Epidermal Transglutaminases.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1996/12//
VL  - 107
IS  - 6
M3  - Article
SP  - 808
EP  - 811
SN  - 0022202X
AB  - Congenital recessive ichthyosis has a broad range of clinical presentations, which may be considered a spectrum of phenotypes with classic lamellar ichthyosis at one pole and classic congenital ichthyosiform erythroderma at the other. The identification of mutations in the transglutaminase-1 gene as a cause of lamellar ichthyosis implicates transglutaminase-1 in other congenital recessive ichthyoses. We investigated two multiplex families with clinical manifestations between the two poles for linkage to the transglutaminase-1 locus on thromesome 14. Strongly negative lod scores prompted a search for linkage to two other epidermally expressed transglutaminases, transglutaminase-2 and transglutaminase-3, on chromosome 20. No evidence for linkage was found. These data confirm the hypothesis that the congenital recessive ichthyoses are genetically heterogeneous and in two families exclude two other transglutaminases that could be considered as candidate loci for at least some of the nonlamellar recessive ichthyoses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ICHTHYOSIS
KW  - TRANSGLUTAMINASES
KW  - EPIDERMIS
KW  - KERATOSIS
KW  - TRANSFERASES
KW  - PHENOTYPE
KW  - <em>genetics</em>
KW  - <em>genodermatosis</em>
KW  - <em>heterogeneity</em>
KW  - <em>linkage</em>
N1  - Accession Number: 12330566; Bale, Sherri J. 1 Russell, Laura J. 1 Lee, Minjoo L. 1 Compton, John G. 1 DiGiovanna, John J. 2; Affiliation:  1: Genetic Studies Section/Laboratory of Skin Biology, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Dermatology Clinical Research Unit, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec96, Vol. 107 Issue 6, p808; Subject Term: ICHTHYOSIS; Subject Term: TRANSGLUTAMINASES; Subject Term: EPIDERMIS; Subject Term: KERATOSIS; Subject Term: TRANSFERASES; Subject Term: PHENOTYPE; Author-Supplied Keyword: <em>genetics</em>; Author-Supplied Keyword: <em>genodermatosis</em>; Author-Supplied Keyword: <em>heterogeneity</em>; Author-Supplied Keyword: <em>linkage</em>; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12330566
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107348380
T1  - Self-report of difficulty in performing functional activities identifies a broad range of disability in old age.
AU  - Langlois JA
AU  - Maggi S
AU  - Harris T
AU  - Simonsick EM
AU  - Ferrucci L
AU  - Pavan M
AU  - Sartori L
AU  - Enzi G
Y1  - 1996/12//12/ 1/1996
N1  - Accession Number: 107348380. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al); Katz Index of Activities of Daily Living; Center for Epidemiologic Studies Depression Scale (CES-D); Rosow-Breslau Higher Level Physical Functions. Grant Information: This work was supported by funding from the Ministry of Welfare of the Veneto Region, by funding to Dr. Maggi from the National Research Council (Italy) (CNR-PF Inv 95R574), and by resources provided by the National Institute on Aging to support collaborative research between the United States and Italy. NLM UID: 7503062. 
KW  - Geriatric Functional Assessment
KW  - Disabled -- In Old Age
KW  - Self Report
KW  - Cross Sectional Studies
KW  - Risk Factors
KW  - Italy
KW  - Odds Ratio
KW  - Activities of Daily Living
KW  - Funding Source
KW  - Health Status
KW  - Comorbidity
KW  - Construct Validity
KW  - Random Sample
KW  - Questionnaires
KW  - Interviews
KW  - Neuropsychological Tests
KW  - Center for Epidemiological Studies Depression Scale
KW  - Multiple Logistic Regression
KW  - P-Value
KW  - Confidence Intervals
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 1421
EP  - 1428
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVE: To describe a broad range of physical disability by examining the association between a four-level measure of disability, based on self-report of difficulty in performing functional activities, and previously identified risk factors for disability. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: A total of 2373 noninstitutionalized men and women aged 65 and older from the Veneto Region of Italy. MEASUREMENTS: Odds ratios for the association of the four levels of disability (none, mild, moderate, and ADL disability) differentiated by this new measure with known risk factors for physical disability. MAIN RESULTS: This summary measure of physical disability distinguished older persons with disability from the population typically classified as nondisabled. Twenty-one percent of study participants were identified as having Activities of Daily Living (ADL) disability (defined as self-report of difficulty in one or more ADLs), and an additional 40% had mild or moderate disability based on degree of difficulty in Instrumental Activities of Daily Living (IADLs) and physical functional activities. Hip fracture and lower extremity performance were strongly independently associated with each level of disability. The association of a range of established risk factors for disability and health care utilization measures with the levels of disability identified in our study, and the trend toward increasing odds with increasing disability, provide evidence of the construct validity of this measure. CONCLUSIONS: Self-report of difficulty in performing functional activities identifies older persons with physical disability not ascertained by self-report of the need for help, the measure typically used to identify disability in older populations. Further studies should evaluate the potential for self-reported difficulty in functional activities to predict important disability-related outcomes.
SN  - 0002-8614
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Suite 3C-309, Bethesda, MD 20892
U2  - PMID: 8951310.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Zhou, Haibo
AU  - Weinberg, Clarice R.
AU  - Wilcox, Allen J.
AU  - Baird, Donna D.
T1  - A Random-Effects Model for Cycle Viability in Fertility Studies.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1996/12//
VL  - 91
IS  - 436
M3  - Article
SP  - 1413
EP  - 1422
SN  - 01621459
AB  - Models for fertility that take into account the timing of intercourse relative to ovulation are needed to estimate the influence of both endogenous and exogenous factors on human fertility. The classical model ,assumes that some menstrual cycles are "viable" and some are not, where "viability" is determined by whether hormonal, uterine, and gamete-related factors are favorable to gestation. Within each viable cycle, the various days with intercourse are assumed to act independently, within each nonviable cycle, the days with intercourse can have no effect. Cycle viability for individual cycles is latent in that it is not ascertainable when conception does not occur. The classical model neglects the statistical dependency of outcomes among menstrual cycles within individual couples. Current marginal approaches cannot determine the degree to which heterogeneity in fecundability is biologically based versus the degree to which it is secondary to variation in intercourse behavior from couple to couple. We describe a random-effects model based on assuming that the cycle viability probability varies from couple to couple according to a beta distribution, and we use an EM algorithm to fit the model. The proposed estimating procedure is fully expandable to allow covariate effects on the beta variate. Our method can be applied more generally whenever dependency among Bernoulli trials is induced by a susceptibility state and the outcomes can be observed only in the aggregate. Based on data from a cohort of couples with no known fertility problems who were attempting pregnancy, cycle viability is found to be heterogeneous among couples. Stratification on the presence or absence of prenatal exposure of the woman to her mother's cigarette smoking revealed a statistically significant difference in the two cycle viability distributions. We discuss differences in the interpretation of the beta model compared to the marginal approach based on generalized estimating equations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MATHEMATICS
KW  - ESTIMATION theory
KW  - HUMAN fertility
KW  - MEDICINE
KW  - BINOMIAL distribution
KW  - MENSTRUAL cycle
KW  - Aggregated Bernoulli outcomes
KW  - Beta distribution
KW  - EM algorithm
KW  - Fertility
KW  - Latent variables
KW  - Random effect
N1  - Accession Number: 9702145880; Zhou, Haibo 1; Weinberg, Clarice R. 2; Wilcox, Allen J. 3; Baird, Donna D. 3; Affiliations: 1: Visiting Assistant Professor, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7400; 2: Mathematical Statistician, Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; 3: Epidemiologist, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; Issue Info: Dec96, Vol. 91 Issue 436, p1413; Thesaurus Term: MATHEMATICS; Thesaurus Term: ESTIMATION theory; Subject Term: HUMAN fertility; Subject Term: MEDICINE; Subject Term: BINOMIAL distribution; Subject Term: MENSTRUAL cycle; Author-Supplied Keyword: Aggregated Bernoulli outcomes; Author-Supplied Keyword: Beta distribution; Author-Supplied Keyword: EM algorithm; Author-Supplied Keyword: Fertility; Author-Supplied Keyword: Latent variables; Author-Supplied Keyword: Random effect; Number of Pages: 10p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article; Full Text Word Count: 7645
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107313108
T1  - Diseases of the adrenal gland.
AU  - Gumowski J
AU  - Loughran M
Y1  - 1996/12//1996 Dec
N1  - Accession Number: 107313108. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - Adrenal Gland Diseases -- Diagnosis
KW  - Adrenal Gland Diseases -- Therapy
KW  - Adrenal Gland Diseases -- Symptoms
KW  - Adrenal Glands -- Physiology
KW  - Adrenal Gland Diseases -- Etiology
KW  - Adrenal Gland Diseases -- Surgery
KW  - Cushing's Syndrome
KW  - Diagnosis, Laboratory
KW  - Adrenal Insufficiency
KW  - Pheochromocytoma
KW  - Adrenal Cortex -- Physiopathology
KW  - Adrenal Gland Diseases -- Drug Therapy
KW  - Adult
KW  - Female
SP  - 747
EP  - 768
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 31
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Diseases of the adrenal gland are rare but potentially lethal. The adrenal cortex and the adrenal medulla function quite differently and independent of each other. Diseases of both hyperfunction as well as hypofunction will be reviewed. Astute nursing assessment and patient education in adrenal signs and symptoms are essential in the management of these diseases. A detailed case study illustrates three diseases of the adrenal gland. Copyright (c) 1996 by W.B. Saunders Company
SN  - 0029-6465
AD  - Clinical Center Nursing Department, National Institutes of Health, 3046 Winter Pine Court, Fairfax, VA 22031
U2  - PMID: 8969336.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Chaturvedi, Santosh K.
AU  - Chandra, Prabha S.
AU  - Channabasavanna, S. M.
AU  - Anantha, N.
AU  - Reddy, B. K. M.
AU  - Sharma, Sanjeev
T1  - LEVELS OF ANXIETY AND DEPRESSION IN PATIENTS RECEIVING RADIOTHERAPY IN INDIA.
JO  - Psycho-Oncology
JF  - Psycho-Oncology
Y1  - 1996/12//
VL  - 5
IS  - 4
M3  - Article
SP  - 343
EP  - 346
PB  - John Wiley & Sons, Inc.
SN  - 10579249
AB  - The objective of this study was to detect the prevalence of anxiety and depressive disorders using the Hospital Anxiety and Depression Scale (HADS) prospectively in patients receiving Radiotherapy (RT) during and after treatment. A total of 100 consecutive cancer patients referred for radiotherapy were included. All patients were administered the Hospital Anxiety and Depression Scale (HADS) conducted at intake, just before starting RT, after finishing the course of RT, and at 3–4 months follow-up. Anxiety and depression were detected frequently in patients receiving RT both prior to treatment and later during follow-up. Frequency of anxiety increased significantly after initiating RT. but later reduced during the follow up assessments [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psycho-Oncology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RADIOTHERAPY
KW  - CANCER patients
KW  - ANXIETY
KW  - MENTAL depression
KW  - MEDICAL care
KW  - INDIA
N1  - Accession Number: 14150982; Chaturvedi, Santosh K. 1 Chandra, Prabha S. 1 Channabasavanna, S. M. 1 Anantha, N. 2 Reddy, B. K. M. 2 Sharma, Sanjeev 2; Affiliation:  1: National Institute of Mental Health and Neurosciences, Bangalore 560 029  2: Department of Radiotherapy, Kidwai Memorial Institute of Oncology,  Bangalore 560 029, India; Source Info: Dec1996, Vol. 5 Issue 4, p343; Subject Term: RADIOTHERAPY; Subject Term: CANCER patients; Subject Term: ANXIETY; Subject Term: MENTAL depression; Subject Term: MEDICAL care; Subject Term: INDIA; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107252413
T1  - Levels of anxiety and depression in patients receiving radiotherapy in India.
AU  - Chaturvedi SK
AU  - Chandra PS
AU  - Channabasavanna SM
AU  - Anantha N
AU  - Reddy BKM
AU  - Sharma S
Y1  - 1996/12//
N1  - Accession Number: 107252413. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Instrumentation: Hospital Anxiety and Depression Scale (HADS). NLM UID: 9214524. 
KW  - Anxiety -- India
KW  - Depression -- India
KW  - Cancer Patients -- Psychosocial Factors -- India
KW  - Radiotherapy -- Psychosocial Factors -- India
KW  - India
KW  - Prospective Studies
KW  - Convenience Sample
KW  - Descriptive Statistics
KW  - Interviews
KW  - Research Instruments
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 343
EP  - 346
JO  - Psycho-Oncology
JF  - Psycho-Oncology
JA  - PSYCHO ONCOL
VL  - 5
IS  - 4
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
SN  - 1057-9249
AD  - National Institute of Mental Health and Neurosciences, Bangalore 560 029
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Haseman, J. K.
AU  - Elwell, M. R.
T1  - Evaluation of False Positive and False Negative Outcomes in NTP Long-Term Rodent Carcinogenicity Studies.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1996/12//
VL  - 16
IS  - 6
M3  - Article
SP  - 813
EP  - 820
SN  - 02724332
AB  - The decision-making process used by the National Toxicology Program (NTP) in its evaluation of long-term rodent carcinogenicity studies was investigated to determine whether or not this procedure resulted in an excessive number of false positive or false negative outcomes. All site-specific tumor incidences that were found to be significantly (p < 0.05) increased either by a trend test or by pairwise comparisons of each dosed group against the controls in 218 NTP 2-year studies with Fischer 344 rats and/or B6C3F1 mice were tabulated and compared to the number of statistically significant tumor increases expected to occur by chance. Our evaluation suggests that false positive rates are fairly low in NTP long-term studies. Assessing false negative rates is more difficult because of the limited sensitivity of the bioassay for detecting subtle carcinogenic effects. Moreover, reduced body weights frequently occur in dosed animals, and the positive correlation between the incidences of certain site-specific tumors and body weight may mask the detection of carcinogenic effects. Despite these difficulties, our analysis did identify one tumor showing evidence of false negative outcomes: interstitial cell tumors of the testis in male Fischer 344 (F344) rats. This tumor showed considerably more significant (p < 0.05) increased incidences than expected by chance, yet none were considered to be chemically-related. However, the biological significance of interstitial cell tumor increases in F344 rats is uncertain because of the high background rate of neoplasia (<90%) for this target site. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogenicity testing
KW  - Toxicology
KW  - Laboratory animals
KW  - Outcome assessment (Medical care)
KW  - Rats
KW  - Tumors
KW  - false negative rates
KW  - False positive rates
KW  - laboratory animal carcinogenicity studies
KW  - National Toxicology Program.
KW  - tumor incidence
N1  - Accession Number: 11782686; Haseman, J. K. 1; Elwell, M. R. 2; Affiliations: 1: Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences,  P.O. Box 12233, Research Triangle Park, North Carolina 27709.; 2: Pathology Branch, National Institute of Environmental Health Sciences,  P.O. Box 12233, Research Triangle Park, North Carolina 27709.; Issue Info: Dec96, Vol. 16 Issue 6, p813; Thesaurus Term: Carcinogenicity testing; Thesaurus Term: Toxicology; Subject Term: Laboratory animals; Subject Term: Outcome assessment (Medical care); Subject Term: Rats; Subject Term: Tumors; Author-Supplied Keyword: false negative rates; Author-Supplied Keyword: False positive rates; Author-Supplied Keyword: laboratory animal carcinogenicity studies; Author-Supplied Keyword: National Toxicology Program.; Author-Supplied Keyword: tumor incidence; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107319329
T1  - A new framework for urinary continence outcomes in long-term care.
AU  - Palmer MH
Y1  - 1996/12//1996 Dec
N1  - Accession Number: 107319329. Language: English. Entry Date: 19970401. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8812256. 
KW  - Urinary Incontinence -- Classification
KW  - Urinary Incontinence -- Nursing
KW  - Long Term Care
KW  - Urinary Incontinence -- Diagnosis
KW  - Minimum Data Set
KW  - Bowel and Bladder Management
KW  - Inpatients
SP  - 146
EP  - 151
JO  - Urologic Nursing
JF  - Urologic Nursing
JA  - UROL NURS
VL  - 16
IS  - 4
CY  - Pitman, New Jersey
PB  - Society of Urologic Nurses & Associates, Inc.
AB  - Careful assessment and individual care planning are especially important when approaching the problems of incontinence in long-term care patients. Identification of appropriate interventions and desired outcomes is assuming greater prominence. This article provides an overview of some of the issues that affect incontinence with long-term patients and presents a refined concept of several classifications of incontinence that direct approaches to care. The classifications are based on whether a patient is dependent or independent on a caregiver to achieve continence. Assumptions, goals, and evidence for effectiveness of these interventions are discussed for the four classifications. Further implications for nursing are also addressed.
SN  - 1053-816X
AD  - National Institute of Nursing Research Clinical Therapeutics Laboratory, Baltimore, Maryland
U2  - PMID: 9258057.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2008-12954-001
AN  - 2008-12954-001
AU  - Allen, John
AU  - Lowman, Cherry
AU  - Miller, William R.
T1  - Perspectives on precipitants of relapse.
JF  - Addiction
JO  - Addiction
JA  - Addiction
Y1  - 1996/12//
VL  - 91
IS  - 12
SP  - S3
EP  - S4
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0965-2140
SN  - 1360-0443
AD  - Allen, John, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Willco Building, Suite 500, 6000 Executive Blvd., Bethesda, MD, US, 20892-7003
N1  - Accession Number: 2008-12954-001. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Allen, John; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20081103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcohols; Clinicians; Experimentation; Relapse (Disorders); Treatment. Classification: Psychological Disorders (3210). Population: Human (10). Page Count: 2. Issue Publication Date: Dec, 1996. 
AB  - The 18 articles in this three-section supplement examine relapse from a number of different perspectives. The four articles in Section I, 'Theoretical Perspectives on Relapse', address conceptual approaches to relapse. Section II, 'Marlatt's Taxonomy of High Risk Situations for Relapse: Replication and Extension', comprises 12 articles that discuss research concerned with identifying factors that predict relapse. Section III, 'Methods for Analyzing Longitudinal Data on Relapse', consists of two articles that explain two different approaches to analyzing longitudinal data on relapse, both appropriate for application in alcohol treatment research. This supplement provides a wealth of information to the researcher and the clinician. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - perspectives
KW  - relapse precipitants
KW  - treatment research
KW  - clinician
KW  - 1996
KW  - Alcohols
KW  - Clinicians
KW  - Experimentation
KW  - Relapse (Disorders)
KW  - Treatment
KW  - 1996
DO  - 10.1111/j.1360-0443.1996.tb02322.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1998-11414-002
AN  - 1998-11414-002
AU  - Shoaib, Mohammed
AU  - Shippenberg, Toni S.
T1  - Adrenalectomy attenuates nicotine-induced dopamine release and locomotor activity in rats.
JF  - Psychopharmacology
JO  - Psychopharmacology
JA  - Psychopharmacology (Berl)
Y1  - 1996/12//
VL  - 128
IS  - 4
SP  - 343
EP  - 350
CY  - Germany
PB  - Springer
SN  - 0033-3158
SN  - 1432-2072
N1  - Accession Number: 1998-11414-002. PMID: 8986004 Other Journal Title: Psychopharmacologia. Partial author list: First Author & Affiliation: Shoaib, Mohammed; National Institutes of Health, National Inst for Drug Abuse, Addiction Research Ctr, Preclinical Pharmacology Research Branch, Baltimore, MD, US. Release Date: 19990101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Adrenalectomy; Dopamine; Nicotine; Nucleus Accumbens. Minor Descriptor: Neurochemistry; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: Dec, 1996. 
AB  - Examined the influence of adrenalectomy (ADX) upon the locomotor depressant, activating and dopamine-releasing properties of nicotine in male rats. Nicotine (.8–1.2 mg/kg) dose-dependently depressed locomotor activity, an effect that was potentiated by ADX, while the locomotor activating effects of a smaller dose (.4 mg/kg) were attenuated by ADX. In both SHAM and ADX Ss chronically treated with nicotine for 5 days (daily injections of .4 mg/kg), the locomotor depressant effects of nicotine did not differ from saline-treated controls. Nicotine (.4 mg/kg) increased extracellular levels of dopamine in the nucleus accumbens. This response was unaffected in Ss pretreated with nicotine for 5 days (daily injections of .4 mg/kg). However, both ADX groups of Ss showed smaller increases in dopamine following administration of nicotine. Results suggest that depletion of circulating corticosteroids can modulate sensitivity to nicotine in rats. The suppressant effects of ADX on nicotine-induced locomotor activity may be due to its effects on dopamine release in the nucleus accumbens. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nicotine
KW  - dopamine release in nucleus accumbens & locomotor activity & suppression
KW  - adrenalectomized male rats
KW  - 1996
KW  - Activity Level
KW  - Adrenalectomy
KW  - Dopamine
KW  - Nicotine
KW  - Nucleus Accumbens
KW  - Neurochemistry
KW  - Rats
KW  - 1996
DO  - 10.1007/s002130050143
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1998-11414-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-01186-018
AN  - 2015-01186-018
AU  - Rho, Jong M.
AU  - Donevan, Sean D.
AU  - Rogawski, Michael A.
T1  - Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.
JF  - The Journal of Physiology
JO  - The Journal of Physiology
JA  - J Physiol
Y1  - 1996/12/01/
VL  - 497
IS  - 2
SP  - 509
EP  - 522
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0022-3751
SN  - 1469-7793
AD  - Rogawski, Michael A., Neuronal Excitability Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-01186-018. Partial author list: First Author & Affiliation: Rho, Jong M.; Neuronal Excitability Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20161027. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gamma Aminobutyric Acid; Hippocampus; Neural Receptors; Pentobarbital; Phenobarbital. Minor Descriptor: Electrical Activity; Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: Dec 1, 1996. Publication History: Accepted Date: Aug 30, 1996; First Submitted Date: May 13, 1996. 
AB  - 1. The direct activation of the GABAA receptor by pentobarbitone (PB) and phenobarbitone (PHB) was characterized in cultured rat hippocampal neurons using whole-cell voltage clamp and single channel recording techniques. 2. In whole-cell recordings, PB and PHB produced a concentration-dependent activation of Clcurrent (EC₅₀ values, 0 33 and 3 0 mm, respectively). The response to the barbiturates was similar to that produced by GABA, although GABA was more potent (EC₅₀, 5.5 µM). PB and PHB were substantially more potent in enhancing the response to 1, UM GABA (EC₅₀ values, 94 uM and 0'89 mm, respectively). The maximal magnitude of the responses to PB was similar to that of the maximal response to GABA or GABA + PB. PHB appeared to be modestly less efficacious. 3. The mean deactivation time constant for whole-cell Cl- currents evoked by 1 mm PB + 1 /SM GABA was significantly longer (480 ± 34 ms) than for 1 mm PB (170 ± 9 ms) or 1 µM GABA (180 ± 14 ms) alone. 4. Whole-cell currents directly activated by 300 µM PB and 1 µM GABA were blocked by the GABA receptor antagonists bicuculline and picrotoxin. 5. Unitary GABAA receptor channel currents evoked by 300 µM PB had similar main conductance, mean open time and mean burst duration as those activated by 2 µM GABA alone. Single channel openings and bursts were of shorter mean duration when 100 and 300 µM PHB were used. 6. High concentrations of PB (1-3 mM) and PHB (3-10 mM) produced a rapid block of currents activated by the barbiturate alone or by the barbiturate in the presence of 1 µM GABA. The estimated IC₅₀ values for block of PB- and PHB-potentiated GABA currents were 2-8 and 12'9 mm, respectively. 7. Single channel currents activated by high concentrations of PB and PHB alone or in the presence of GABA demonstrated flickering, probably reflecting fast channel block. 8. We conclude that the gating of the GABAA receptor channel by PHB and PB is functionally similar to that produced by the natural agonist GABA alone, but distinct from that obtained when barbiturates modulate the response to GABA. At high concentrations, the barbiturates produce a channel blocking action that limits the maximum total current conducted by the channel. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GABAA receptor
KW  - pentobarbitone
KW  - phenobarbitone
KW  - barbiturates
KW  - hippocampal neurons
KW  - rats
KW  - Cl- current
KW  - gamma aminobutyric acid currents
KW  - 1996
KW  - Gamma Aminobutyric Acid
KW  - Hippocampus
KW  - Neural Receptors
KW  - Pentobarbital
KW  - Phenobarbital
KW  - Electrical Activity
KW  - Rats
KW  - 1996
DO  - 10.1113/jphysiol.1996.sp021784
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-01186-018&site=ehost-live&scope=site
UR  - rogawski@nih.go
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-12954-006
AN  - 2008-12954-006
AU  - Lowman, Cherry
AU  - Allen, John
AU  - Stout, Robert L.
T1  - Replication and extension of Marlatt's taxonomy of relapse precipitants: Overview of procedures and results.
JF  - Addiction
JO  - Addiction
JA  - Addiction
Y1  - 1996/12//
VL  - 91
IS  - 12
SP  - S51
EP  - S71
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0965-2140
SN  - 1360-0443
AD  - Lowman, Cherry, NIH, NIAAA, Willco Building, Suite 505, 6000 Executive Boulevard, Bethesda, MD, US, 20892-7003
N1  - Accession Number: 2008-12954-006. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Lowman, Cherry; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, US. Institutional Authors: Relapse Research Group. Other Publishers: Blackwell Publishing. Release Date: 20081103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Coping Behavior; Psychometrics; Relapse (Disorders); Responses; Taxonomies. Classification: Psychological & Physical Disorders (3200). Population: Human (10). References Available: Y. Page Count: 21. Issue Publication Date: Dec, 1996. 
AB  - The Relapse Replication and Extension Project (RREP) was a multisite study to replicate and extend Marlatt's taxonomy of relapse precipitants. In addition to replicating Marlatt's original taxonomic system, three independent research teams utilized prospective designs to identify additional predictors of relapse and developed and evaluated two alternative systems for assessing high risk relapse situations. This overview describes the replication methodology, summarizes seven RREP studies completed by the three research groups, and discusses five cross-cutting conclusions emerging from the studies. These conclusions are: (1) reliability of Marlatt's taxonomic system was variable both within and across the three research sites; (2) Marlatt's taxonomic system showed little predictive validity in analyses that used pretreatment relapse data to predict post-treatment relapse, but there are important unresolved issues; (3) an alternative taxonomy provided little more predictive validity than the original taxonomy even though it measured more dimensions of relapse situations and provided greater analytic flexibility; (4) the Reasons for Drinking Questionnaire appeared to be a successful psychometric transformation of Marlatt's taxonomy, one which did demonstrate predictive validity; and (5) Marlatt's taxonomy was based on a time-intensive model of relapse prediction whereas RREP prospective analyses represented time-extensive models of relapse prediction. Coping responses are noted to be effective predictors of relapse under both models. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Marlatts taxonomy
KW  - relapse precipitants
KW  - Relapse Replication and Extension Project
KW  - coping responses
KW  - 1996
KW  - Coping Behavior
KW  - Psychometrics
KW  - Relapse (Disorders)
KW  - Responses
KW  - Taxonomies
KW  - 1996
U1  - Sponsor: National Institute on Alcohol Abuse and Alcoholism, US. Grant: ADM 281-91- 0011. Other Details: Brown University. Recipients: No recipient indicated
U1  - Sponsor: Research Institute on Addictions. Grant: ADM 281-91-0007. Recipients: No recipient indicated
U1  - Sponsor: University of New Mexico, US. Grant: ADM 281-91-0006. Recipients: No recipient indicated
DO  - 10.1080/09652149638809
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12954-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-12954-007
AN  - 2008-12954-007
AU  - Longabaugh, Richard
AU  - Rubin, Amy
AU  - Stout, Robert L.
AU  - Zywiak, William H.
AU  - Lowman, Cherry
T1  - The reliability of Marlatt's taxonomy for classifying relapses.
JF  - Addiction
JO  - Addiction
JA  - Addiction
Y1  - 1996/12//
VL  - 91
IS  - 12
SP  - S73
EP  - S88
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0965-2140
SN  - 1360-0443
AD  - Longabaugh, Richard, Center for Alcohol and Addiction Studies, Brown University, Box G, Providence, RI, US, 02912
N1  - Accession Number: 2008-12954-007. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Longabaugh, Richard; Center for Alcohol and Addiction Studies, Brown School of Medicine, Providence, RI, US. Other Publishers: Blackwell Publishing. Release Date: 20081103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Addiction; Clinical Practice; Clinicians; Taxonomies. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Methodology: Empirical Study; Experimental Replication; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Dec, 1996. 
AB  - Marlatt's focus on the relapse situation has had a major impact upon research and clinical practice in treating addictions. One component of his work was the development of a taxonomy for classifying precipitants of relapse. This taxonomy has been incorporated into the nomenclature of clinicians and clinical researchers as part of an explanatory framework for understanding relapses. Despite the taxonomy's influence it has never been examined for the reliability of its use across research studies. The present study compared the reliability of independent classifications of 149 relapse episodes by trained raters at three research laboratories. Despite considerable across-laboratory training, reliability was found to be inconsistent for research purposes. It is concluded that comparability of results based on Mariatt's relapse taxonomy across independent studies must be subject to question, and assumptions necessary for the aggregation of a knowledge base are not supported. Recommendations are offered for improving the reliability of the taxonomy and the methods used to collect taxonomy data. More generally, questions regarding the value of the specific relapse categories, as well as the overall taxonomy, are raised. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - reliability
KW  - Marlatts taxonomy
KW  - relapses
KW  - clinical practice
KW  - addictions
KW  - clinicians
KW  - 1996
KW  - Addiction
KW  - Clinical Practice
KW  - Clinicians
KW  - Taxonomies
KW  - 1996
U1  - Sponsor: Sponsor name not included. Grant: ADM 281-91-0011. Recipients: No recipient indicated
DO  - 10.1080/09652149638818
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12954-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-08155-001
AN  - 1997-08155-001
AU  - Knable, Michael B.
AU  - Hyde, Thomas M.
AU  - Murray, Angela M.
AU  - Herman, Mary M.
AU  - Kleinman, Joel E.
T1  - A postmortem study of frontal cortical dopamine D1 receptors in schizophrenics, psychiatric controls and normal controls.
JF  - Biological Psychiatry
JO  - Biological Psychiatry
JA  - Biol Psychiatry
Y1  - 1996/12//
VL  - 40
IS  - 12
SP  - 1191
EP  - 1199
CY  - Netherlands
PB  - Elsevier Science
SN  - 0006-3223
N1  - Accession Number: 1997-08155-001. PMID: 8959283 Partial author list: First Author & Affiliation: Knable, Michael B.; National Institute of Mental Health, Intramural Research Program, Clinical Brain Disorders Branch, Washington, DC, US. Release Date: 19970101. Correction Date: 20130107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Neural Receptors; Prefrontal Cortex; Receptor Binding; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 9. Issue Publication Date: Dec, 1996. 
AB  - Tested the hypothesis that aberrant dopaminergic innervation in frontal and cingulate cortices of schizophrenic patients might be revealed by examining dopamine D1 receptor density in these brain regions. A quantitative autoradiographic assay with [–3H]-SCH 23390 was performed with postmortem brain samples from 7 schizophrenic patients, 8 normal controls, 9 neuroleptic-treated controls, and 9 nonpsychotic Ss who died by suicide. There was a significant elevation in specific binding of [–3H]-SCH 23390 in the intermediate layer of the prefrontal cortex from neuroleptic-treated controls. Elevated binding in several layers from prefrontal and cingulate cortex was observed in schizophrenic Ss, although these results did not reach statistical significance. When data from Ss who had received neuroleptics were compared to Ss who had not received neuroleptics there was a significant elevation in receptor density in both the prefrontal and cingulate cortices. These data suggest that elevated [–3H]-SCH 23390 binding in human prefrontal and cingulate cortices may occur with chronic neuroleptic treatment, although increased receptor density that may exist as a feature of psychotic illnesses cannot be excluded. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - frontal cortical dopamine D1 receptors
KW  - postmortem schizophrenics
KW  - 1996
KW  - Dopamine
KW  - Neural Receptors
KW  - Prefrontal Cortex
KW  - Receptor Binding
KW  - Schizophrenia
KW  - 1996
DO  - 10.1016/S0006-3223(96)00116-3
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-08155-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13548-030
AN  - 2008-13548-030
AU  - Tian, M.
AU  - Jacobson, C.
AU  - Gee, S. H.
AU  - Campbell, K. P.
AU  - Carbonetto, S.
AU  - Jucker, M.
T1  - Dystroglycan in the cerebellum is a laminin α2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1996/12//
VL  - 8
IS  - 12
SP  - 2739
EP  - 2747
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Jucker, M., Institute of Pathology, University of Basel, CH-4003, Basel, Switzerland
N1  - Accession Number: 2008-13548-030. PMID: 8996823 Partial author list: First Author & Affiliation: Tian, M.; Gerontology Research Center, National Institute on Aging, National Institute of Health, Baltimore, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20100927. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Jucker, M. Major Descriptor: Proteins; Purkinje Cells. Minor Descriptor: Cerebellum; Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 1996. Publication History: Accepted Date: Jul 11, 1996; First Submitted Date: Jul 11, 1996. 
AB  - Dystroglycan is a core component of the dystrophin receptor complex in skeletal muscle which links the extracellular matrix to the muscle cytoskeleton. Dystrophin, dystrophin-related protein (DRP, utrophin) and dystroglycan are present not only in muscles but also in the brain. Dystrophin is expressed in certain neuronal populations while DRP is associated with perivascular astrocytes. To gain insights into the function and molecular interactions of dystroglycan in the brain, we examined the localization of α-and β-dystroglycan at the cellular and subcellular levels in the rat cerebellum. In blood vessels, we find a-dystroglycan associated with the laminin a2-chain-rich parenchymal vascular basement membrane and β-dystroglycan associated with the endfeet of perivascular astrocytes. We also show that a-dystroglycan purified from the brain binds a2-chain-containing laminin-2. These observations suggest a dystroglycan-mediated linkage between DRP in perivascular astrocytic endfeet and laminin-2 in the parenchymal basement membrane similar to that described in skeletal muscle. This linkage of the astrocytic endfeet to the vascular basement membrane is likely to be important for blood vessel formation and stabilization and for maintaining the integrity of the blood-brain barrier. In addition to blood vessel labelling, we show that β-dystroglycan in the rat cerebellum is associated with the surface of Purkinje cell bodies, dendrites and dendritic spines. Dystrophin has previously been localized to the inner surface of the plasma membrane of Purkinje cells and is enriched at postsynaptic sites. Thus, the present results also support the hypothesis that dystrophin interacts with dystroglycan in cerebellar Purkinje neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dystroglycan
KW  - cerebellum
KW  - laminin
KW  - binding proteins
KW  - Purkinje cells
KW  - rats
KW  - 1996
KW  - Proteins
KW  - Purkinje Cells
KW  - Cerebellum
KW  - Rats
KW  - 1996
U1  - Sponsor: Aluminum Association. Recipients: Jucker, M.
U1  - Sponsor: Retinitis Pigementosa Foundation. Recipients: Carbonetto, S.
DO  - 10.1111/j.1460-9568.1996.tb01568.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13548-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 104792925
T1  - Replication and extension of Marlatt's taxonomy of relapse precipitants: overview of procedures and results. The Relapse Research Group.
AU  - Lowman, C
AU  - Allen, J
AU  - Stout, R L
Y1  - 1996/12/02/Dec1996 Supplement
N1  - Accession Number: 104792925. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Supplement Title: Dec1996 Supplement. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcoholism -- Rehabilitation
KW  - Cognitive Therapy
KW  - Social Behavior
KW  - Substance Use Disorders -- Rehabilitation
KW  - Adult
KW  - Alcoholism -- Classification
KW  - Alcoholism -- Psychosocial Factors
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Personality Assessment
KW  - Recurrence
KW  - Reproducibility of Results
KW  - Risk Factors
KW  - Substance Use Disorders -- Classification
KW  - Substance Use Disorders -- Psychosocial Factors
KW  - Treatment Outcomes
SP  - S51
EP  - 71
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 91
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - The Relapse Replication and Extension Project (RREP) was a multisite study to replicate and extend Marlatt's taxonomy of relapse precipitants. In addition to replicating Marlatt's original taxonomic system, three independent research teams utilized prospective designs to identify additional predictors of relapse and developed and evaluated two alternative systems for assessing high risk relapse situations. This overview describes the replication methodology, summarizes seven RREP studies completed by the three research groups, and discusses five cross-cutting conclusions emerging from the studies. These conclusions are: (1) reliability of Marlatt's taxonomic system was variable both within and across the three research sites; (2) Marlatt's taxonomic system showed little predictive validity in analyses that used pretreatment relapse data to predict post-treatment relapse, but there are important unresolved issues; (3) an alternative taxonomy provided little more predictive validity than the original taxonomy even though it measured more dimensions of relapse situations and provided greater analytic flexibility; (4) the Reasons for Drinking Questionnaire appeared to be a successful psychometric transformation of Marlatt's taxonomy, one which did demonstrate predictive validity; and (5) Marlatt's taxonomy was based on a time-intensive model of relapse prediction whereas RREP prospective analyses represented time-extensive models of relapse prediction. Coping responses are noted to be effective predictors of relapse under both models.
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-7003, USA.
U2  - PMID: 8997781.
DO  - 10.1111/j.1360-0443.1996.tb02327.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104792925&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105855045
T1  - Cigarette smoking among U.S. adults by state and region: estimates from the current population survey.
AU  - Shopland DR
AU  - Hartman AM
AU  - Gibson JT
AU  - Mueller MD
AU  - Kessler LG
AU  - Lynn WR
Y1  - 1996/12/04/
N1  - Accession Number: 105855045. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Smoking -- Epidemiology
KW  - Demography
KW  - Ethnic Groups -- Statistics and Numerical Data
KW  - Female
KW  - Male
KW  - Occupations and Professions
KW  - Population
KW  - Prevalence
KW  - Smoking -- Ethnology
KW  - United States
SP  - 1748
EP  - 1758
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 88
IS  - 23
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7337, USA.
U2  - PMID: 8944005.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105855045&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107319157
T1  - Exploratory study of residents' perceptions of a housing facility for pediatric patients and family members.
AU  - Wiener L
AU  - Riekert K
AU  - Pizzo PA
AU  - Siegel K
AU  - Battles H
Y1  - 1996/12/09/
N1  - Accession Number: 107319157. Language: English. Entry Date: 19970401. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309337. 
KW  - Housing
KW  - Family Attitudes
KW  - Patient Attitudes -- In Infancy and Childhood
KW  - Exploratory Research
KW  - Semi-Structured Interview
KW  - Child
KW  - Support, Psychosocial
KW  - Chi Square Test
KW  - Quality of Life
KW  - Adolescence
KW  - Adult
KW  - Adaptation, Psychological
KW  - Family Centered Care
KW  - Human
SP  - 69
EP  - 80
JO  - Journal of Psychosocial Oncology
JF  - Journal of Psychosocial Oncology
JA  - J PSYCHOSOC ONCOL
VL  - 14
IS  - 3
PB  - Taylor & Francis Ltd
SN  - 0734-7332
AD  - National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107319157&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - LiWang, Andy C.
AU  - Bax, Ad
T1  - Equilibrium Protium/Deuterium Fractionation of Backbone Amides in U—13C/15N Labeled Human Ubiquitin by Triple Resonance NMR.
JO  - Journal of the American Chemical Society
JF  - Journal of the American Chemical Society
Y1  - 1996/12/18/
VL  - 118
IS  - 50
M3  - Article
SP  - 12864
EP  - 12865
SN  - 00027863
AB  - Describes the equilibrium protium and deuterium fractionation of backbone amides in human ubiquitin by triple resonance neural magnetic resonance. Cause of the magnetization exchange between the solvent and protein; Factors influencing the attenuation of resonances of proteins; Calculation of the ratio of the integrated intensities from the peak heights.
KW  - DEUTERIUM
KW  - NUCLEAR magnetic resonance
KW  - PROTIUM (Isotope)
KW  - AMIDES
KW  - UBIQUITIN
N1  - Accession Number: 11206997; LiWang, Andy C. 1 Bax, Ad 1; Affiliation:  1: Laboratory of Chemical Physics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda, Maryland 20892-0520; Source Info: 12/18/96, Vol. 118 Issue 50, p12864; Subject Term: DEUTERIUM; Subject Term: NUCLEAR magnetic resonance; Subject Term: PROTIUM (Isotope); Subject Term: AMIDES; Subject Term: UBIQUITIN; Number of Pages: 2p; Illustrations: 2 Graphs; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11206997&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - Gen
ID  - 9999-13463-000
AN  - 9999-13463-000
AU  - Williams, David R.
AU  - Yu, Yan
AU  - Jackson, James S.
AU  - Anderson, Norman B.
T1  - Race-Related Stress Measure
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1997///
AD  - Williams, David R., University of Michigan, Institute for Social Research, P.O. Box 1248, Ann Arbor, Michigan, United States, 48106-1248
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-13463-000. Partial author list: First Author & Affiliation: Williams, David R.; University of Michigan, Institute for Social Research, Survey Research Center, Ann Arbor, Michigan, United States. Release Date: 20120813. Correction Date: 20151207. Instrument Type: Test. Language: English. Constructs: Racial Discrimination; Race Related Stress; Classification: Social, Group, and Interpersonal Relationships (7600); Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Interview
AB  - Purpose: The purpose of the Race-Related Stress Measure is to assess the degree to which individuals experience major events involving discrimination as well as everyday discrimination.
AB  - Description: The Race-Related Stress Measure (Williams et al., 1997) was developed for use in a study that examined the extent to which racial differences in socio-economic status (SES), social class and acute and chronic indicators of perceived discrimination, as well as general measures of stress can account for black–white differences in self-reported measures of physical and mental health. This 12-item measure consists of two aspects of race-related stress: discrimination and everyday discrimination. Both are framed in the context of unfairness instead of in the context of race. Discrimination, a measure of major experiences of unfair treatment, is a count of 3 items. The second measure, everyday discrimination, attempts to measure more chronic, routine, and relatively minor experiences of unfair treatment. It sums 9 items that capture the frequency of several experiences in the day-to-day lives of respondents (i.e. 'being treated with less courtesy than others'). In a sample of black and white respondents from the community, internal consistency was established. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Racial Discrimination
KW  - Race-Related Stress Measure
KW  - Test Development
KW  - Unfair Treatment
U5  - Race-Related Stress Measure [Test Development]Racial Differences in Physical and Mental Health: Socio-economic Status, Stress and Discrimination. (AN: 2005-11586-005 from PsycINFO) Williams, David R.; Yu, Yan; Jackson, James S.; Anderson, Norman B.; Jul, 1997. Source: Journal of Health Psychology. 2(3), Sage Publications, US; Jul, 1997; Administration: Interview Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Location: United States; Sample: Adult Respondents Keywords: Racial Discrimination; Race-Related Stress Measure; Test Development; Unfair Treatment; Subjects: Measurement; Race and Ethnic Discrimination; Stress; Stress and Coping Measures; Test Construction;
DO  - 10.1037/t13463-000
L3  - Full; Full text; 999913463_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-13463-000&site=ehost-live&scope=site
UR  - wildavid@umich.edu
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-16921-000
AN  - 9999-16921-000
AU  - Williams, David R.
AU  - Yu, Yan
AU  - Jackson, James S.
AU  - Anderson, Norman B.
T1  - Discrimination Measure
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1997///
AD  - Williams, David R., Harvard University, Department of Sociology, 615 Kresge Building, Boston, Massachusetts, United States, 02115
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-16921-000. Partial author list: First Author & Affiliation: Williams, David R.; University of Michigan, Ann Arbor, Michigan, United States. Release Date: 20130211. Correction Date: 20151109. Instrument Type: Test. Language: English. Constructs: Discrimination; Classification: Culture, Racial, and Ethnic Identity (5700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Discrimination Measure is to assess individuals' experiences of discrimination.
AB  - Description: The Discrimination Measure (Williams et al., 1997) was developed to assess individuals' experiences of discrimination. This measure was designed by the authors for a study examining the extent to which racial differences in socio-economic status (SES), social class and acute and chronic indicators of perceived discrimination, as well as general measures of stress can account for black–white differences in self-reported measures of physical and mental health. The Discrimination Measure was administered to a sample of 1139 adult respondents, 18 years of age and older, residing in Wayne, Oakland and Macomb counties in Michigan, including the city of Detroit. The measure was conceptualized as a dimension of race-related stress. Unlike prior research, this measure was framed in the context of unfairness instead of in the context of race. Discrimination, a measure of major experiences of unfair treatment, is a count of three items. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Discrimination Measure
KW  - Life Experiences
KW  - Test Development
U5  - Discrimination Measure [Test Development]Racial Differences in Physical and Mental Health: Socio-economic Status, Stress and Discrimination. (AN: 2005-11586-005 from PsycINFO) Williams, David R.; Yu, Yan; Jackson, James S.; Anderson, Norman B.; Jul, 1997. Source: Journal of Health Psychology. 2(3), Sage Publications, US; Jul, 1997; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Location: United States Keywords: Discrimination Measure; Life Experiences; Test Development; Subjects: Discrimination; Social Discrimination; Test Construction;
DO  - 10.1037/t16921-000
L3  - Full; Full text; 999916921_full_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-16921-000&site=ehost-live&scope=site
UR  - dwilliam@hsph.harvard.edu
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - KNEPPER, MARK A.
T1  - Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin.
JO  - American Journal of Physiology: Renal Physiology
JF  - American Journal of Physiology: Renal Physiology
Y1  - 1997/01//
VL  - 41
IS  - 1
M3  - Article
SP  - F3
EP  - F12
SN  - 1931857X
AB  - The purpose of this review is to illustrate the application of molecular methodologies to the investigation of a fundamentally integrative problem in renal physiology, namely, the mechanism of regulation of water excretion by the kidney and the concomitant concentration of solutes in the urine. A new revolution in renal physiology is occurring as new research tools have become available as a result of the cloning of cDNAs for many of the major transporters and receptors in the renal medulla. Among the important renal medullary transporters are the aquaporin water channels, which mediate the osmotic water transport across renal medullary epithelia. One of these water channels, aquaporin-2, has been shown to be the target for short-term regulation of collecting duct water permeability by vasopressin. In addition, two collecting duct water channels, aquaporin-2 and aquaporin-3, are targets for long-term regulation by vasopressin through effects on the absolute expression levels of the water channel proteins. This review focuses on the mechanisms of both short- and long-term regulation of these water channels by vasopressin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - aquaporins
KW  - collecting duct
N1  - Accession Number: 97747161; KNEPPER, MARK A. 1; Affiliation:  1: Renal Mechanisms Section, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-0951; Source Info: Jan97, Vol. 41 Issue 1, pF3; Author-Supplied Keyword: aquaporins; Author-Supplied Keyword: collecting duct; Number of Pages: 10p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=97747161&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Simons-Morton, Bruce G.
AU  - McKenzie, Thomas J.
AU  - Stone, Elaine
AU  - Mitchell, Paul
AU  - Osganian, Voula
AU  - Strikmiller, Patricia K.
AU  - Ehlinger, Sally
AU  - Cribb, Peter
AU  - Nader, Philip R.
T1  - Physical Activity in a Multiethnic Population of Third Graders in Four States.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/01//
VL  - 87
IS  - 1
M3  - Article
SP  - 45
EP  - 50
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This research assessed the amount of daily physical activity in a multiethnic sample of US third-grade students. Methods. Physical activity interviews were conducted with 2410 third graders from 96 schools in four states. Blood pressure, cholesterol, body mass index, timed run for distance, physical-activity self-efficacy, and perceived support for physical activity were also assessed. Results. Students reported a daily average of 89.9 minutes of moderate to vigorous physical activity, 34.7 minutes of vigorous activity, and 120.4 minutes of sedentary behavior; however, 36.6% obtained less than 60 minutes of sedentary behavior; however, 36.6% obtained less than 60 minutes of moderate to vigorous physical activity daily, and 12.8% reported less than 30 minutes. Boys reported more physical and sedentary activity than girls; White children reported more activity than Black or Hispanic children; California children reported the most activity and Louisiana children the least. Geographic location, male gender, lower cholesterol, higher perceived efficacy in physical activity, and higher social support were associated with more physical activity. Conclusions. Average reported activity met the Year 2000 objectives; however, many students reported less than recommended amounts of activity. These findings support the need for health promotion programs that increase the number of physically active children. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STUDENTS -- Health
KW  - PHYSICAL fitness
KW  - BLOOD pressure
KW  - PEDIATRICS
KW  - MULTICULTURALISM
KW  - HEALTH promotion
KW  - UNITED States
N1  - Accession Number: 9702240095; Simons-Morton, Bruce G. 1 McKenzie, Thomas J. 2 Stone, Elaine 3 Mitchell, Paul 4 Osganian, Voula 4 Strikmiller, Patricia K. 5 Ehlinger, Sally 6 Cribb, Peter 7 Nader, Philip R. 8; Affiliation:  1: National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Md.  2: San Diego State University, Calif.  3: National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Md.  4: New England Researh Institute, Watertown, MA.  5: Tulane School of Public Health and Tropical Medicine, Baton Rouge, La.  6: University of Minnesota, Minneapolis.  7: University of Texas, Austin  8: University of San California, San Diego; Source Info: Jan1997, Vol. 87 Issue 1, p45; Subject Term: STUDENTS -- Health; Subject Term: PHYSICAL fitness; Subject Term: BLOOD pressure; Subject Term: PEDIATRICS; Subject Term: MULTICULTURALISM; Subject Term: HEALTH promotion; Subject Term: UNITED States; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 4935
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107354157
T1  - Physical activity in a multiethnic population of third graders in four states.
AU  - Simons-Morton B
AU  - McKenzie TJ
AU  - Stone E
AU  - Mitchell P
AU  - Osganian V
AU  - Strikmiller PK
AU  - Ehlinger S
AU  - Cribb P
AU  - Nader PR
Y1  - 1997/01//
N1  - Accession Number: 107354157. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: Children's Physical Activity Interview. Grant Information: Grant U01 HL 39927, U01 HL 39852, U01 HL39870, U01 HL 33906, and U01 HL 39880 from the National Heart, Lung, and Blood Institute, National Institutes of Health. NLM UID: 1254074. 
KW  - Exercise
KW  - Students, Elementary
KW  - Cultural Diversity
KW  - Structured Interview
KW  - Funding Source
KW  - California
KW  - Louisiana
KW  - Minnesota
KW  - Texas
KW  - Risk Factors
KW  - Questionnaires
KW  - Pearson's Correlation Coefficient
KW  - Analysis of Covariance
KW  - Time Factors
KW  - Surveys
KW  - Data Analysis Software
KW  - Interviews
KW  - Child
KW  - Male
KW  - Female
KW  - Human
SP  - 45
EP  - 50
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 87
IS  - 1
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This research assessed the amount of daily physical activity in a multiethnic sample of US third-grade students. METHODS: Physical activity interviews were conducted with 2410 third graders from 96 schools in four states. Blood pressure, cholesterol, body mass index, timed run for distance, physical-activity self-efficacy, and perceived support for physical activity were also assessed. RESULTS: Students reported a daily average of 89.9 minutes of moderate to vigorous physical activity, 34.7 minutes of vigorous activity, and 120.4 minutes of sedentary behavior; however, 36.6% obtained less than 60 minutes of moderate to vigorous physical activity daily, and 12.8% reported less than 30 minutes. Boys reported more physical and sedentary activity than girls; White children reported more activity than Black or Hispanic children; California children reported the most activity and Louisiana children the least. Geographic location, male gender, lower cholesterol, higher perceived efficacy in physical activity, and higher social support were associated with more physical activity. CONCLUSIONS: Average reported activity met the Year 2000 objectives; however, many students reported less than recommended amounts of activity. These findings support the need for health promotion programs that increase the number of physically active children.
SN  - 0090-0036
AD  - National Institute of Child Health and Human Development and Human Development, Rockville, MD 20852
U2  - PMID: 9065225.
DO  - 10.2105/AJPH.87.1.45
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107354157&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107234830
T1  - An evaluation of technologies for identifying acute cardiac ischemia in the emergency department: executive summary of a National Heart Attack Alert Program Working Group report.
AU  - Selker HP
AU  - Zalenski RJ
AU  - Antman EM
AU  - Auferheide TP
AU  - Bernard SA
AU  - Bonow RO
AU  - Gibler WB
AU  - Hagen MD
AU  - Johnson P
AU  - Lau J
AU  - McNutt RA
AU  - Ornato J
AU  - Schwartz JS
AU  - Scott JD
AU  - Tunick PA
AU  - Weaver WD
Y1  - 1997/01//1997 Jan
N1  - Accession Number: 107234830. Corporate Author: National Heart Attack Alert Program Coordinating Committee Working Group. Language: English. Entry Date: 19980101. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8002646. 
KW  - Acute Disease
KW  - Myocardial Ischemia -- Diagnosis
KW  - Emergency Service -- Standards
KW  - Technology, Medical -- Standards
KW  - United States
KW  - Computerized Literature Searching
KW  - Echocardiography
KW  - Exercise Test, Cardiopulmonary
KW  - Predictive Validity
KW  - Diagnosis, Computer Assisted
KW  - Creatine Kinase -- Diagnostic Use
KW  - Creatine Kinase Isoenzymes -- Diagnostic Use
KW  - Biochemical Instruments
KW  - Electrocardiography
KW  - Thallium Radioisotopes -- Diagnostic Use
KW  - Technetium Compounds -- Diagnostic Use
KW  - Evaluation Research
KW  - Emergency Service -- Methods
KW  - Human
SP  - 1
EP  - 12
JO  - Annals of Emergency Medicine
JF  - Annals of Emergency Medicine
JA  - ANN EMERG MED
VL  - 29
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
SN  - 0196-0644
AD  - National Heart Attack Alert Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 8998085.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107234830&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107234831
T1  - An evaluation of technologies for identifying acute cardiac ischemia in the emergency department: a report from a National Heart Attack Alert Program Working Group.
AU  - Selker HP
AU  - Zalenski RJ
AU  - Antman EM
AU  - Aufderheide TP
AU  - Bernard SA
AU  - Bonow RO
AU  - Gibler WB
AU  - Hagen MD
AU  - Johnson P
AU  - Lau J
AU  - McNutt RA
AU  - Ornato J
AU  - Schwartz JS
AU  - Scott JD
AU  - Tunick PA
AU  - Weaver WD
Y1  - 1997/01//1997 Jan
N1  - Accession Number: 107234831. Corporate Author: National Heart Attack Alert Program Coordinating Committee Working Group. Language: English. Entry Date: 19980101. Revision Date: 20150818. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8002646. 
KW  - Acute Disease
KW  - Myocardial Ischemia -- Diagnosis
KW  - Electrocardiography
KW  - Emergency Service -- Standards
KW  - Echocardiography
KW  - Diagnosis, Computer Assisted
KW  - Creatine Kinase -- Diagnostic Use
KW  - Creatine Kinase Isoenzymes -- Diagnostic Use
KW  - Biochemical Instruments
KW  - Thallium Radioisotopes -- Diagnostic Use
KW  - Technetium Compounds -- Diagnostic Use
KW  - Emergency Service -- Methods
KW  - United States
KW  - Computerized Literature Searching
KW  - Evaluation Research
KW  - Predictive Validity
KW  - Prospective Studies
KW  - Clinical Trials
KW  - Technology, Medical -- Standards
KW  - Spearman's Rank Correlation Coefficient
KW  - Quality Assessment
KW  - Sensitivity and Specificity
KW  - Confidence Intervals
KW  - Myocardial Ischemia -- Radiography
KW  - Myocardial Ischemia -- United States
KW  - Myocardial Ischemia -- Physiopathology
KW  - Myocardial Ischemia -- Metabolism
KW  - Electrocardiography -- Methods
KW  - Electrocardiography -- Economics
KW  - Exercise Test, Cardiopulmonary
KW  - Human
SP  - 13
EP  - 87
JO  - Annals of Emergency Medicine
JF  - Annals of Emergency Medicine
JA  - ANN EMERG MED
VL  - 29
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
SN  - 0196-0644
AD  - National Heart Attack Alert Program, National Heart, Lung, and Blood Institute, Bethesda, Maryland
U2  - PMID: 8998086.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107234831&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107318977
T1  - Strategies for laboratory and patient management. Practice protocol for the examination of specimens removed from patients with cancer of the breast: a publication of the Cancer Committee, College of American Pathologists.
AU  - Henson DE
AU  - Oberman HA
AU  - Hutter RVP
Y1  - 1997/01//1997 Jan
N1  - Accession Number: 107318977. Corporate Author: College of American Pathologists. Cancer Committee. Language: English. Entry Date: 19970401. Revision Date: 20150711. Publication Type: Journal Article; protocol. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7607091. 
KW  - Biopsy
KW  - Breast Neoplasms -- Diagnosis
KW  - Diagnosis, Laboratory -- Standards
KW  - Breast -- Pathology
KW  - Documentation
SP  - 27
EP  - 33
JO  - Archives of Pathology & Laboratory Medicine
JF  - Archives of Pathology & Laboratory Medicine
JA  - ARCH PATHOL LAB MED
VL  - 121
IS  - 1
CY  - Northfield, Illinois
PB  - College of American Pathologists
SN  - 0003-9985
AD  - Early Detection Branch, Division of Cancer Prevention and Control, EPN Bldg, Room 330, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 9111089.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107318977&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - PROSCHAN, MICHAEL A.
T1  - Conditional power with Fisher's least significant difference procedure.
JO  - Biometrika
JF  - Biometrika
Y1  - 1997/01//
VL  - 84
IS  - 1
M3  - Article
SP  - 197
EP  - 208
SN  - 00063444
AB  - Conditional power calculations are very useful for assessing the likelihood of an ultimately statistically significant result given the current data We show how to calculate conditional power in a multi-armed trial using the classic Fisher least sigmhnt difference, LSD, procedure. We obtain upper bounds on the probabilities of Type 1 and Type 2 errors analogous to those in two-armed trials, and show that these bounds are equalities under continuous monitoring. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FISHER information
KW  - CLINICAL trials
KW  - CONDITIONAL probability
KW  - BAYESIAN analysis
KW  - MULTIPLICITY (Mathematics)
KW  - Monitoring
KW  - Multi-armed trial
KW  - Stochastic curtailment
N1  - Accession Number: 80081298; PROSCHAN, MICHAEL A. 1; Affiliation:  1: National Heart, Lung, and Blood Institute, II Rockledge Center, 6701 Rockledge Drive MSC 7938, Bethesda, Maryland 20892-7938, U.S.A. e-mail: Proscham@gwgate.nhlbi.nih.gov; Source Info: 1997, Vol. 84 Issue 1, p197; Subject Term: FISHER information; Subject Term: CLINICAL trials; Subject Term: CONDITIONAL probability; Subject Term: BAYESIAN analysis; Subject Term: MULTIPLICITY (Mathematics); Author-Supplied Keyword: Monitoring; Author-Supplied Keyword: Multi-armed trial; Author-Supplied Keyword: Stochastic curtailment; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SLUD, ERIC V.
AU  - KORN, EDWARD L.
T1  - Semiparametric two-sample tests in clinical trials with a post-randomisation response indicator.
JO  - Biometrika
JF  - Biometrika
Y1  - 1997/01//
VL  - 84
IS  - 1
M3  - Article
SP  - 221
EP  - 230
SN  - 00063444
AB  - In many clinical trials involving survival endpoints, one has additional data on some binary indicator of ‘response’, such as initial tumour shrinkage in cancer trials. This paper studies the case of randomised clinical trials where the response indicator is available shortly after randomisation, and where one can assume that, within each stratum defined by the response indicator, a two treatment-group proportional-hazards model holds. The same model may also describe some incompletely randomised or observational studies. Asymptotic relative efficiencies for Kaplan-Meier-based estimators versus maximum partial likelihood estimators are examined under this model for estimating either the difference in survival probabilities at a specified time or the parameter estimated by the logrank numerator. It is shown that the efficiency gains using the model are more promising when estimating the difference in survival probabilities. An example is given comparing the long-term survival experience of two groups of patients with advanced Hodgkin's disease [ABSTRACT FROM AUTHOR]
AB  - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TUMORS
KW  - RESEARCH
KW  - CLINICAL trials
KW  - RANDOMIZATION (Statistics)
KW  - HODGKIN'S disease -- Treatment
KW  - PROPORTIONAL hazards models
KW  - ASYMPTOTIC efficiencies (Statistics)
KW  - KAPLAN-Meier estimator
KW  - Auxiliary endpoints
KW  - Delta method
KW  - Maximum partial likelihood estimator
KW  - Propotional hazards model
KW  - Stratification
KW  - Surrogate endpoints
N1  - Accession Number: 80081300; SLUD, ERIC V. 1 KORN, EDWARD L. 2; Affiliation:  1: Information Management Services Inc. and Mathematics Department, University of Maryland, College Park Maryland 20742, U.S.A. e-mail: evs@math.umd.edu  2: National Cancer Institute Bethesda, Maryland 20892, U.S.A. e-mail: korne@dct.nci.nih.gov; Source Info: 1997, Vol. 84 Issue 1, p221; Subject Term: TUMORS; Subject Term: RESEARCH; Subject Term: CLINICAL trials; Subject Term: RANDOMIZATION (Statistics); Subject Term: HODGKIN'S disease -- Treatment; Subject Term: PROPORTIONAL hazards models; Subject Term: ASYMPTOTIC efficiencies (Statistics); Subject Term: KAPLAN-Meier estimator; Author-Supplied Keyword: Auxiliary endpoints; Author-Supplied Keyword: Delta method; Author-Supplied Keyword: Maximum partial likelihood estimator; Author-Supplied Keyword: Propotional hazards model; Author-Supplied Keyword: Stratification; Author-Supplied Keyword: Surrogate endpoints; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107323542
T1  - Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A.
AU  - Cormier JN
AU  - Salgaller ML
AU  - Prevette T
AU  - Barracchini KC
AU  - Rivoltini L
AU  - Restifo NP
AU  - Rosenberg SA
AU  - Marincola FM
Y1  - 1997/01//1997 Jan-Feb
N1  - Accession Number: 107323542. Language: English. Entry Date: 19970601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9513568. 
KW  - Immunization
KW  - Melanoma -- Prevention and Control
KW  - Immunity, Cellular
KW  - Cancer Patients
KW  - Peptides -- Therapeutic Use
KW  - Vaccines
KW  - Injections, Subcutaneous
KW  - Interleukin 2
KW  - Antigens
KW  - T Lymphocytes
KW  - Fisher's Exact Test
KW  - T-Tests
KW  - Two-Tailed Test
KW  - Cytokines
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 37
EP  - 44
JO  - Cancer Journal from Scientific American
JF  - Cancer Journal from Scientific American
JA  - CANCER J SCI AM
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - PURPOSE. In this study, we tested the effectiveness of a melanoma-associated antigen-derived pepide, MART-1(27-35), in eliciting cellular immune responses in vivo in the context of a phase I active immunization protocol. This peptide (AAGIGILTV) corresponds to residues 27-35 from the nonmutated melanoma-associated antigen MART-1/Melan A and is recognized by most melanoma-specific, HLA-A*0201-restricted, tumor-infiltrating lymphocytes. To test the in vivo induction of cytotoxic T lymphocyte (CTL) sensitization, we compared CTL reactivity in vitro from peripheral blood mononuclear cell (PBMC) pools obtained before and after vaccination. PATIENTS AND METHODS. MART-1(27-35) was administered to HLA-A*0201 melanoma patients subcutaneously in an emulsification with incomplete Freund's adjuvant. A vaccination course included four inoculations of peptide at 3-week intervals. PBMC collected by leukapheresis and separated by Ficoll-Hypaque gradient before and after vaccination were analyzed in 18 patients by in vitro sensitization with MART-1(27-35). To induce MART-1(27-35)-secific CTL, PBMC were incubated with 1 microM peptide (on day 0) and interleukin-2 (IL-2) (300 IU/mL, on days 1 and 4 after each stimulation). At weekly intervals, cells were harvested and an aliquot was cryopreserved for later analysis. The remaining cells were replated and restimulated using irradiated autologous PBMC pulsed with 1 microM of relevant peptide. After three restimulations, all samples from one patient were tested simultaneously for HLA-A*0201-restricted anti-MART-1(27-35) reactivity by microcytotoxicity and cytokine (IFN-gamma) release assays. RESULTS. Toxicities were minimal and consisted of local irritation at the site of vaccine administration. None of the patients sustained a clinical response. The first eight patients were monitored by inducing CTL reactivity from PBMC obtained preimmunization and after two and four vaccinations. Only two prevaccination cultures were reactive to MART-1, compared with five and seven cultures from PBMC obtained after two and four vaccinations, respectively. Thus, an enhancement in cytotoxic activity could be detected in postvaccination CTL cultures, and serial vaccine administrations appeared to boost the detectability of cytotoxicity in vitro. For completeness, the analysis compared prevaccination with post-vaccination PBMC cultures. Specific anti-MART-1(27-35) cytotoxicity (>/= 10 lytic units) could be detected in two prevaccination and 12 postvaccination cultures after two in vitro stimulations. In 15 postvaccination CTL cultures, a more than threefold increase in specific release of IFN-gamma was noted, compared with prevaccination. DISCUSSION. In vivo administration of a melanoma-associated antigen peptide, emulsified in incomplete Freund's adjuvant, could safely augment CTL reactivity against epitopes commonly expressed by melanoma cells. Although the enhancement of CTL reactivity did not achieve tumor regression, it is possible that the use of recombinant immunogens with increased immunomodulatory capabilities in future clinical trials could reach the threshold of CTL activation necessary for tumor regression.
SN  - 1081-4442
AD  - Surgery Branch, Clinical Oncology Program, Division of Clinical Services, National Cancer Institute, Bethesda, Maryland
U2  - PMID: 9072306.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Horowitz, Lisa A.
AU  - Putnam, Frank W.
AU  - Noll, Jennie G.
AU  - Trickett, Penelope K.
T1  - FACTORS AFFECTING UTILIZATION OF TREATMENT SERVICES BY SEXUALLY ABUSED GIRLS.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1997/01//
VL  - 21
IS  - 1
M3  - Article
SP  - 35
EP  - 48
SN  - 01452134
AB  - This study describes the naturalistic therapy experiences of a sample of sexually abused girls and the relationship of these experiences to demographic factors, abuse experiences, psychopathology, and family functioning. The sample consisted of 81 sexually abused girls, aged 6 to 16, participating in a longitudinal study of the effects of sexual abuse. Results indicated strong effects for abuse experiences and child psychopathology on the total amount of therapy received. Patterns of treatment utilization were associated with ethnic minority status, but these differences are confounded by differing abuse experiences for racial groups in the sample. Other patterns of treatment utilization are discussed, as well as issues for further research and implications for treatment providers. (English) [ABSTRACT FROM AUTHOR]
AB  - Este estudio describe las experiencias de la terapia naturalista en una muestra de muchachas abusadas sexualmente y la relación de estas experiencias con factores demográficos, experiencias de abuso, psicopatologia y funcionamiento familiar. La muestra consistió en 81 muchachas abusadas sexuamente de 6 a 16 años de edad, participando en un estudio longitudinal sobre los efectos del abuso sexual. Los resultados indicaron que las experiencias de abuso y la psicopatologia infantil tenían fuertes efectos en la cantidad de terapia recibida. Se asociaron los patrones de utilización del tratamiento con el status de minoria étnica, pero estas diferencias se confunden por las variadas experiencias abusivas en los grupos raciales de la uestra. Se discuten otros patrones de tratamiento asi como aspectos relativos a investigaciones futuras y las implicaciones para los que ofrecen el tratmiento. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Cette étude décrit la relation entre diverses expériences thérapeutiques et certains facteurs tels les expériences d'agressions vécues, la psychopathologie, le fonctionnement familial et les caractéristiques démographiques. L'échantillon comprenait 81 filles abusées sexuellement, âgées de 6 à 16 ans et qui faisaient partie d'une étude longitudinale portant sur les effets des agressions sexuelles. Les résultats indiquent que les expériences d'agression et la psychopathologie étaient des facteurs exerçant une influence marquée sur l'ampleur du traitement reçu. L'appartenance à un groupe ethnique minoritaire s'est aussi avéré un facteur, mais ces résultats sont obsurcis par le fait que les agressions étaient différentes d'un groupe racial à l'autre. L'article discute d'autres aspects concernant le recours au traitement et propose des recherches à poursuivre pour éclairer les intervenants. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD sexual abuse
KW  - SEXUALLY abused children
KW  - GIRLS
KW  - THERAPEUTICS
KW  - CHILD psychopathology
KW  - Child sexual abuse
KW  - Therapy dropout
KW  - Treatment
N1  - Accession Number: 9708103499; Horowitz, Lisa A. 1 Putnam, Frank W. 1 Noll, Jennie G. 1 Trickett, Penelope K. 2; Affiliation:  1: Unit on Developmental Traumatology, National Institute of Mental Health, Bethesda, MD, USA  2: University of Southern California, Los Angeles, CA, USA; Source Info: Jan1997, Vol. 21 Issue 1, p35; Subject Term: CHILD sexual abuse; Subject Term: SEXUALLY abused children; Subject Term: GIRLS; Subject Term: THERAPEUTICS; Subject Term: CHILD psychopathology; Author-Supplied Keyword: Child sexual abuse; Author-Supplied Keyword: Therapy dropout; Author-Supplied Keyword: Treatment; Number of Pages: 14p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
ID  - 2011-24938-020
AN  - 2011-24938-020
AU  - Fozard, James L.
AU  - Vercruyssen, Max
AU  - Reynolds, Sara L.
AU  - Hancock, P. A.
ED  - Rogers, Wendy A.
ED  - Rogers, Wendy A., (Ed)
T1  - Longitudinal analysis of age-related slowing: BLSA reaction time data.
T2  - Designing for an aging population: Ten years of human factors/ergonomics research.
Y1  - 1997///
SP  - 89
EP  - 93
CY  - Santa Monica, CA, US
PB  - Human Factors and Ergonomics Society
SN  - 0-945289-08-1
SN  - 978-0-945289-08-1
AD  - Fozard, James L., National Institutes of Health, National Institute on Aging, Gerontology Research Center, Rm 1E08, Baltimore, MD, US, 21224
N1  - Accession Number: 2011-24938-020. Partial author list: First Author & Affiliation: Fozard, James L.; National Institutes of Health, National Institute on Aging, Baltimore, MD, US. Release Date: 20121008. Correction Date: 20160616. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-945289-08-1, Paperback; 978-0-945289-08-1, Paperback. Language: English. Major Descriptor: Age Differences; Human Factors Engineering; Human Sex Differences; Reaction Time. Minor Descriptor: Longitudinal Studies. Classification: Developmental Psychology (2800); Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. References Available: Y. Page Count: 5. 
AB  - Reported are preliminary findings from analyses of cross-sectional and longitudinal reaction time data collected on 865 male and 453 female volunteers who ranged in age from 20 to 96 years. Evident in both simple and disjunctive reaction time measures was a consistent slowing with age. In nearly all cases, males were faster than females but gender differences were negligible for the simple reaction time (SRT) compared to disjunctive reaction time (DRT). Repeated testing within subjects over 2-8 years also showed age-related slowing across decades. Cross-sectional studies have been criticized for overestimating the actual age-related slowing found in longitudinal analysis. However, this was not the case in the present research. Similar effects were observed in analyses of data from all subjects on their first visit (n = 1318 subjects) compared to data from all subjects over all of their visits (n = 3855 subject visits) compared to data from only those subjects across decades who were tested repeatedly over at least 8 years (n = 314 subjects X 5 visits = 1570 subject visits). Findings from this research have human factors implications for task design, personnel selection, performance prediction, accident analysis, human tests and measurements, and demographic norms, to mention a few. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - age-related slowing
KW  - reaction time
KW  - gender differences
KW  - longitudinal research
KW  - human factors implications
KW  - 1997
KW  - Age Differences
KW  - Human Factors Engineering
KW  - Human Sex Differences
KW  - Reaction Time
KW  - Longitudinal Studies
KW  - 1997
U1  - Sponsor: National Institutes of Health, National Institute on Aging, Baltimore Longitudinal Study of Aging, US. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Occupational Safety and Health's (NIOSH) Southern California Educational Resource Center, Parsons Foundation, University of Southern California Biomedical Research Support Fund, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
ID  - 2011-24938-024
AN  - 2011-24938-024
AU  - Rogers, Wendy A.
AU  - Fisk, Arthur D.
AU  - Giambra, Leonard M.
AU  - Rosenberg, Edwin H.
ED  - Rogers, Wendy A.
ED  - Rogers, Wendy A., (Ed)
T1  - Identifying the learning capabilities of older adults: Associative and priority learning.
T2  - Designing for an aging population: Ten years of human factors/ergonomics research.
Y1  - 1997///
SP  - 109
EP  - 113
CY  - Santa Monica, CA, US
PB  - Human Factors and Ergonomics Society
SN  - 0-945289-08-1
SN  - 978-0-945289-08-1
N1  - Accession Number: 2011-24938-024. Partial author list: First Author & Affiliation: Rogers, Wendy A.; Georgia Institute of Technology, Atlanta, GA, US. Release Date: 20121008. Correction Date: 20160616. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-945289-08-1, Paperback; 978-0-945289-08-1, Paperback. Language: English. Major Descriptor: Age Differences; Aging; Perceptual Learning. Classification: Developmental Psychology (2800). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. References Available: Y. Page Count: 5. 
AB  - Effective search performance is determined by two important factors: memory load and display load. Memory load factors can be reduced by 'associative learning' where memory-set elements become unitized and the stimuli are compared as a 'category rather than serially'. Display-load effects can be reduced by target-distractor differentiation, a process referred to as 'priority learning'. In this paper we describe a three-phased experiment conducted to examine how those factors affected search performance for young and old subjects (mean ages, 24 and 71). Subjects were first trained in two varied mapping (VM) conditions (Phase 1): (1) Associative—allowed unitization of the stimulus sets; (2) Nonassociative—inhibited unitization. In Phase 1 all subjects unitized the associative sets thus implying maintenance of associative learning. In Phase 2, the stimuli were consistently mapped (CM) thus allowing the opportunity for priority learning. Following CM training young adults' performance was qualitatively superior to old adults'. In Phase 3, the CM target and distractor roles were reversed to assess the strength of CM learning. The attention-capturing strength (a measure of priority learning) was age-dependent with young adults showing greater effects. The results demonstrate that age differences in perceptual learning are primarily a function of a disruption in priority learning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - associative & priority learning
KW  - older adults
KW  - perceptual learning
KW  - 1997
KW  - Age Differences
KW  - Aging
KW  - Perceptual Learning
KW  - 1997
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107167124
T1  - Impact of Human Genome Project on epidemiologic research.
AU  - Ellsworth DL
AU  - Hallman M
AU  - Boerwinkle E
Y1  - 1997/01//
N1  - Accession Number: 107167124. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Grant Information: grants HL51021 and HL54481 from the National Heart, Lung, and Blood Institute. NLM UID: 7910703. 
KW  - Epidemiological Research
KW  - Human Genome Project
KW  - Genetics, Medical
KW  - Resource Databases, Health
KW  - Genetic Markers
KW  - DNA
KW  - Ethics, Medical
KW  - Funding Source
SP  - 3
EP  - 13
JO  - Epidemiologic Reviews
JF  - Epidemiologic Reviews
JA  - EPIDEMIOL REV
VL  - 19
IS  - 1
PB  - Oxford University Press / USA
SN  - 0193-936X
AD  - Epidemiology and Biometry Program, Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, MD
U2  - PMID: 9360897.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - CROWELL, JAMES A.
AU  - PAGE, JOHN G.
AU  - RODMAN, LARRY E.
AU  - HEATH, JAMES E.
AU  - GOLDENTHAL, EDWIN I.
AU  - HALL, LEROY B.
AU  - KELLOFF, GARY J.
T1  - Chronic Toxicity Studies of 5-(2-Pyrazinyl)-4-methyl-l,2-dithiole-3-thione, a Potential Chemopreventive Agent1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/01//
VL  - 35
IS  - 1
M3  - Article
SP  - 9
EP  - 21
PB  - Oxford University Press / USA
SN  - 02720590
AB  - The synthetic compound Oltipraz, 5-(2-pyraziny1)-4-methyl-1,2- dithiole-3-thione, is related to the 1,2-dithiolthiones naturally found in cruciferous vegetables, the consumption of which has been epidemiologically associated with reduced frequency of colorectal cancers. Oltipraz has shown chemopreventive efficacy in numerous laboratory epithelial cancer models and is a potential chemopreventive, antimutagenic compound that specifically induces Phase II enzymes. Thirteen-week and 1-year toxicity studies in rats and dogs were performed to characterize the toxicities of the compound at high dosages and to support potential further development as a chemopreventive agent in clinical trials. Administration to rats by gavage for 13 weeks at dosages of 5 and 50 mg/kg/day and for 52 weeks at dosages of 10, 30, and 60 mg/kg/ day produced effects on the liver and on clinical chemistry and hematology parameters. Absolute and relative liver weight increases correlated with diffuse hypertrophy in the mid- and highdose males and centrilobular hypertrophy in the high-dose females. Granularity of hepatocyte cytoplasm was also observed. These anatomical findings were associated with dose-associated slight increases in albumin, total protein, and cholesterol in the males and a moderate increase in cholesterol only in the females. In addition, slight decreases in erythrocyte count, hemoglobin, and hematocrit and reticulocyte elevations occurred. The no effect dose was considered 10 mg/kg/day. Administration by capsule to dogs at dosages of 10 and 100 mg/kg/day for 13 weeks and of 5, 15, and 60 mg/kg/day for 52 weeks also produced effects on the same endpoints noted in the rodent studies. In the 13-week study, precipitate was observed in the bile canaliculi, and gonadal atrophy and increased pituitary weights occurred in the males. Cholesterol and alkaline phosphatase activity were slightly elevated in both studies. Decreased hematology parameters in the 13-week study also occurred. The no effect dose was considered to be 5 mg/kg/ day. Oltipraz is being carefully evaluated in clinical trials as a potential antimutagenic compound. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxicity testing
KW  - Colon cancer
KW  - Gender
KW  - Thiones
KW  - Clinical trials
N1  - Accession Number: 82418155; CROWELL, JAMES A. 1; PAGE, JOHN G. 2; RODMAN, LARRY E. 2; HEATH, JAMES E. 2; GOLDENTHAL, EDWIN I. 3; HALL, LEROY B. 4; KELLOFF, GARY J. 1; Affiliations: 1: National Cancer Institute, Chemoprevention Branch Bethesda, Maryland 20892; 2: † Southern Research Institute Birmingham, Alabama 35205; 3: ‡ MPI Research Mattawan, Michigan 49071; 4: § Hoffman LaRoche Nutley, New Jersey 07003; Issue Info: 1997, Vol. 35 Issue 1, p9; Thesaurus Term: Toxicity testing; Subject Term: Colon cancer; Subject Term: Gender; Subject Term: Thiones; Subject Term: Clinical trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - BOORMAN, G. A.
AU  - GAUGER, J. R.
AU  - JOHNSON, T. R.
AU  - TOMLINSON, M. J.
AU  - FINDLAY, J. C.
AU  - TRAVLOS, G. S.
AU  - MCCORMICK, D. L.
T1  - Eight-Week Toxicity Study of 60 Hz Magnetic Fields in F344 Rats and B6C3F1 Mice.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/01//
VL  - 35
IS  - 1
M3  - Article
SP  - 55
EP  - 63
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Toxicity studies were performed by exposing F344/N rats and B6C3F1 mice (10 animals per sex per species per group) to transient-free, linearly polarized 60 Hz magnetic fields for 8 weeks. Targeted magnetic fields strengths used were 0 gauss (G; sham control fields did not exceed 0.001 G), 0.02 G, 2 G, and 10 G. Exposure was whole-body and continuous for 18.5 hr per day, 7 days per week. An additional group of rats and mice was exposed intermittently (1 hr on/1 hr off) to 10 G fields for the same period of time. Endpoints evaluated included morbidity, mortality, gross pathology, histopathology, body/organ weights, clinical chemistry (rats only), and hematology (rats only). All mice and all male rats survived until the end of the study. One female rat (2-G exposure group) died during Week 7 of the study; the death was not attributed to magnetic field exposure. In both studies, the mean body weight gains of exposed animals were similar to those of the respective controls. There were no gross, histological, hematological, or biochemical lesions attributed to magnetic field exposure. Statistically significant increases in liver weight and liver to body weight ratio occurred in female rats of all exposure groups but only at the termination. These data suggest that, for the variables evaluated in these studies, an 8-week exposure to linear-polarized, transientfree 60 Hz magnetic fields at field intensities of up to 10 G is not associated with significant toxicity in F344/N rats and B6C3F1 mice. Furthermore, there was no toxicity observed in animals receiving intermittent (1 hr on/l hr off) exposures to 10-G fields. A 2-year study in F344/N rats and B6C3F1 mice is nearing completion of the in-life phase without overt toxicity in any exposed group. It is premature, however, to make any prediction concerning the possible influence of exposure to 60 Hz magnetic fields on cancer rates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxicity testing
KW  - Public health
KW  - Magnetic fields
KW  - Rats as laboratory animals
KW  - Mice as laboratory animals
KW  - Pathological histology
N1  - Accession Number: 82418151; BOORMAN, G. A. 1; GAUGER, J. R. 2; JOHNSON, T. R. 2; TOMLINSON, M. J. 3; FINDLAY, J. C. 2; TRAVLOS, G. S. 1; MCCORMICK, D. L. 2; Affiliations: 1: National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; 2: † IIT Research Institute, 10 West 35th Street Chicago, Illinois 60616; 3: ‡ Pathology Associates, Inc. 10 West 35th Street, Chicago, Illinors 60616; Issue Info: 1997, Vol. 35 Issue 1, p55; Thesaurus Term: Toxicity testing; Thesaurus Term: Public health; Thesaurus Term: Magnetic fields; Subject Term: Rats as laboratory animals; Subject Term: Mice as laboratory animals; Subject Term: Pathological histology; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - GEN
AU  - Hubbard, S M
AU  - Thurn, A
T1  - The National Cancer Institute's CancerNet: a reliable source of current cancer information on the Internet
JO  - Health Care on the Internet
JF  - Health Care on the Internet
Y1  - 1997///
VL  - 1
IS  - 3
M3  - Article
SP  - 15
EP  - 22
SN  - 10894187
AB  - The International Cancer Information Center (ICIC) of the National Cancer Institute (NCI) provides up-to-date, accurate cancer information through CancerNet, an online service. CancerNet is comprised of a comprehensive knowledge base that includes peer-reviewed statements from Physician Data Query (PDQ); fact sheets, publications, and NCI news; detailed information about ongoing clinical trials; selected information from the Journal of the National Cancer Institute; and CANCERLIT topic searches. The role CancerNet plays in providing timely and accurate cancer information to health professionals and consumers is discussed.
KW  - CONSUMERS -- Information services
KW  - Cancer
KW  - Healthcare
KW  - Information networks
N1  - Accession Number: ISTA3204427; Hubbard, S M 1; Thurn, A; Affiliations: 1 : National Cancer Institute, Bethesda, MD;  Source Info: 1997, Vol. 1 Issue 3, p15; Note: Update Code: 3200; Subject Term: CONSUMERS -- Information services; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Healthcare; Author-Supplied Keyword: Information networks; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Inada, Toshiya
AU  - Dobashi, Izumi
AU  - Sigita, Tetsuyoshi
AU  - Inagaki, Ataru
AU  - Kitao, Yoshie
AU  - Matsuda, Genichi
AU  - Kato, Shingo
AU  - Takano, Toshiya
AU  - Yagi, Gohei
AU  - Asai, Masahiro
T1  - Search for a Susceptibility Locus to Tardive Dyskinesia<FNR></FNR><FN>This work was carried out at the National Institute of Mental Health in Chiba, Japan. </FN>.
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1997/01//Jan/Feb97
VL  - 12
IS  - 1
M3  - Article
SP  - 35
EP  - 39
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD. © 1997 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human Psychopharmacology: Clinical & Experimental is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TARDIVE dyskinesia
KW  - EXTRAPYRAMIDAL disorders
KW  - GENETIC polymorphisms
KW  - DOPAMINE
KW  - MOVEMENT disorders
KW  - dopamine transporter
KW  - DRD2
KW  - DRD3
KW  - gene
KW  - polymorphism
KW  - tardive dyskinesia
N1  - Accession Number: 11821961; Inada, Toshiya 1 Dobashi, Izumi 1 Sigita, Tetsuyoshi 1,2 Inagaki, Ataru 3 Kitao, Yoshie 4 Matsuda, Genichi 5 Kato, Shingo 6 Takano, Toshiya 2 Yagi, Gohei 6 Asai, Masahiro 6; Affiliation:  1: National Institute of Mental Health, National Center of Neurology and Psychiatry, 1-7-3, Kohnodai, Ichikawashi, Chiba 272, Japan  2: Department of Microbiology, Keio University, School of Medicine, Tokyo, Japan  3: Yamanashi Prefectural Kita Hospital, Yamanashi, Japan  4: National Kohnodai Hospital, National Center of Neurology and Psychiatry, Chiba, Japan  5: National Psychiatric Institute of Shimofusa, Chiba, Japan  6: Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan; Source Info: Jan/Feb97, Vol. 12 Issue 1, p35; Subject Term: TARDIVE dyskinesia; Subject Term: EXTRAPYRAMIDAL disorders; Subject Term: GENETIC polymorphisms; Subject Term: DOPAMINE; Subject Term: MOVEMENT disorders; Author-Supplied Keyword: dopamine transporter; Author-Supplied Keyword: DRD2; Author-Supplied Keyword: DRD3; Author-Supplied Keyword: gene; Author-Supplied Keyword: polymorphism; Author-Supplied Keyword: tardive dyskinesia; Number of Pages: 5p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105823292
T1  - Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies.
AU  - Lubin JH
AU  - Boice JD Jr
Y1  - 1997/01//01/01/97
N1  - Accession Number: 105823292. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Air Pollution, Indoor -- Adverse Effects
KW  - Environmental Exposure -- Adverse Effects
KW  - Lung Neoplasms -- Chemically Induced
KW  - Lung Neoplasms -- Epidemiology
KW  - Radon -- Adverse Effects
KW  - Canada
KW  - Case Control Studies
KW  - China
KW  - Finland
KW  - Missouri
KW  - New Jersey
KW  - Relative Risk
KW  - Sweden
KW  - Human
SP  - 49
EP  - 57
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 8978406.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107266899
T1  - The effects of exercise training on resting prostacyclin and thromboxane A2 in older adults.
AU  - Kauffman RD
AU  - Sforzo GS
AU  - Frost B
AU  - Todd MK
Y1  - 1997/01//
N1  - Accession Number: 107266899. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9415639. 
KW  - Platelet Aggregation
KW  - Exercise
KW  - Exercise Physiology
KW  - Eicosanoids
KW  - Eicosanoids -- Physiology
KW  - Adaptation, Physiological
KW  - Eicosanoids -- Analysis
KW  - Exercise Test, Cardiopulmonary
KW  - Oxygen Consumption
KW  - Control Group
KW  - Repeated Measures
KW  - Analysis of Variance
KW  - Analysis of Covariance
KW  - Aged
KW  - Female
KW  - Male
KW  - Human
SP  - 59
EP  - 70
JO  - Journal of Aging & Physical Activity
JF  - Journal of Aging & Physical Activity
JA  - J AGING PHYS ACTIVITY
VL  - 5
IS  - 1
CY  - Champaign, Illinois
PB  - Human Kinetics Publishers, Inc.
AB  - Ten adult volunteers participated in 16 weeks of cardiovascular exercise training (EG) to determine the effects of training on resting prostacyclin (PGI2) and thromboxane A2 (TXA2). Six volunteers of similar age served as sedentary controls (CG). Blood was collected in tubes after training and eicosanoids were measured by standard 125I RIA methods. Over the 16 weeks of the study, PGI2 decreased 48% for EG and 33% for CG. There were no between-group differences for PGI2 values. No significant within-group changes in TXA2 were found, whereas between-group pretraining TXA2 values were significantly different. A time main effect for PGI2 may indicate a seasonal shift in this eicosanoid; however, the additional 15% decrease in PGI2 for EG may be due to a training-induced reduction in PGI2 substrate and/or endothelial sensitivity to agonists. The lack of within-group changes in TXA2 may be due to a combination of high platelet turnover and a training stimulus inadequate to alter platelet function.
SN  - 1063-8652
AD  - Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 5 Research Court, Rockville, MD 20850
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88458139
T1  - Determinants of postchemotherapy nausea and vomiting in patients with cancer. Quality of Life and Symptom Control Committees of the National Cancer Institute of Canada Clinical Trials Group.
AU  - Osoba, David
AU  - Zee, Benny
AU  - Pater, Joseph
AU  - Warr, David
AU  - Latreille, Jean
AU  - Kaizer, Leonard
AU  - Osoba, D
AU  - Zee, B
AU  - Pater, J
AU  - Warr, D
AU  - Latreille, J
AU  - Kaizer, L
Y1  - 1997/01//
N1  - Accession Number: 88458139. Language: English. Entry Date: 19970901. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Health-Related Hardiness Scale (HRHS). NLM UID: 8309333. 
KW  - Vomiting -- Psychosocial Factors
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Nausea -- Psychosocial Factors
KW  - Quality of Life
KW  - Health Status
KW  - Male
KW  - Nausea -- Chemically Induced
KW  - Medical Records
KW  - Risk Factors
KW  - Vomiting -- Chemically Induced
KW  - Sex Factors
KW  - Interpersonal Relations
KW  - Analysis of Variance
KW  - Vomiting -- Epidemiology
KW  - Female
KW  - Middle Age
KW  - Nausea -- Epidemiology
KW  - Incidence
KW  - Scales
SP  - 116
EP  - 123
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To assess whether prechemotherapy health-related quality-of-life (HQL) variables are associated with postchemotherapy nausea and vomiting (PCNV), and to determine their relationship to patient and treatment variables.Patients and Methods: Eight hundred thirty-two chemotherapy-naive patients scheduled to receive antiemetic regimens containing a 5-hydroxytryptamine (5-HT3) antagonist with or without dexamethasone for moderately or highly emetogenic chemotherapy were enrolled. HQL was measured by the self-report European Organization for Research and Treatment of Cancer (EORTC) Care Quality of Life Questionnaire (QLQ-C30) within 7 days before chemotherapy. Prechemotherapy HQL scores, as well as other patient, disease, and treatment variables were compared in the groups of patients who had PCNV and those who did not have PCNV. All variables were assessed initially in a univariate analysis and then together in a multivariate analysis using step-wise logistic regression. The final model generated by the multivariate analyses was used in a risk factor analysis to predict PCNV.Results: Univariate analyses identified 10 HQL variables and five patient and treatment characteristics that were associated with PCNV. In the multivariate analysis, the variables remaining in the final model included low social functioning, prechemotherapy nausea, female gender, highly emetogenic chemotherapy, and the lack of maintenance antiemetics (5-HT3 antagonists with or without dexamethasone) after chemotherapy. A history of low alcohol use was also associated with PCV, whereas increased fatigue and lower performance status were associated with PCN. In the risk factor analysis, the incidence of PCV increased from 20% in those having no risk factors to 76% in those having any four of the six risk factors.Conclusion: Several pretreatment HQL, patient, and treatment characteristics are associated with the occurrence of PCNV. Patients about to receive moderately or highly emetogenic chemotherapy should be screened for these factors and additional measures, such as behavior modification and modification of antiemetic therapy, should be considered in attempts to improve the control of PCNV.
SN  - 0732-183X
AD  - British Columbia Cancer Agency, Vancouver
AD  - University of British Columbia, Vancouver
AD  - National Cancer Institute of Canada Clinical Trials Group and Queen's University, Kingston
AD  - Princess Margaret Hospital/Ontario Cancer Institute and University of Toronto, Toronto
AD  - Hotel Dieu de Montreal, Montreal
AD  - University of Montreal, Montreal
AD  - Credit Valley Professional Building, Mississauga, Canada
AD  - British Columbia Cancer Agency, Vancouver, Canada
U2  - PMID: 8996132.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107313492
T1  - Parental expressed needs: a preliminary guide for services and interventions.
AU  - Wiener L
AU  - Riekert K
AU  - Steinberg SM
AU  - Pizzo P
Y1  - 1997/01//
N1  - Accession Number: 107313492. Language: English. Entry Date: 19970301. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Health Promotion/Education; Peer Reviewed; USA. Instrumentation: Need Assessment Survey. NLM UID: 9613967. 
KW  - Human Needs (Psychology)
KW  - Caregivers
KW  - HIV Infections -- In Infancy and Childhood
KW  - Parents
KW  - Research Instruments
KW  - Surveys
KW  - Needs Assessment
KW  - Fisher's Exact Test
KW  - Chi Square Test
KW  - Information Needs
KW  - Descriptive Statistics
KW  - Convenience Sample
KW  - Age Factors
KW  - Acquired Immunodeficiency Syndrome -- Transmission
KW  - Race Factors
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Human
SP  - 35
EP  - 52
JO  - Journal of HIV/AIDS Prevention & Education for Adolescents & Children
JF  - Journal of HIV/AIDS Prevention & Education for Adolescents & Children
JA  - J HIV AIDS PREV EDUC ADOLESC CHILD
VL  - 1
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - This study examined the expressed needs of 150 caregivers of HIV-infected children. The authors assessed the frequency of reported needs and examined the effect of variables that may influence them. The variables include: the caregiver's relationship to the child, their HIV-status, and race, the age of the child, the route of transmission, and the child's awareness of their own HIV diagnosis. The study delineates the different needs articulated by caregivers for the HIV-infected children at three different developmental stages, and by the caregivers' HIV-status and relationship to the children. The most urgent needs found were for mental health services and health education. The age of the child, the parent's HIV status, and the child's awareness of his or her diagnosis had the most impact on the types of services caregivers requested.
SN  - 1069-837X
AD  - Pediatric Branch, National Cancer Institute, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106384004
T1  - Methadone Treatment Quality Assurance System (MTQAS): a federal effort to assess the feasibility of using outcome indicators for methadone treatment.
AU  - Czechowicz D
AU  - Hubbard RL
AU  - Phillips CD
AU  - Fountain DL
AU  - Cooper JR
AU  - Molinari SP
AU  - Luckey JW
AU  - Graham LA
Y1  - 1997/01//
N1  - Accession Number: 106384004. Language: English. Entry Date: 20060120. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9707735. 
KW  - Methadone -- Therapeutic Use
KW  - Treatment Outcomes -- Evaluation
KW  - Program Development
KW  - Quality of Health Care
KW  - Substance Abuse -- Drug Therapy
SP  - 11
EP  - 24
JO  - Journal of Maintenance in the Addictions
JF  - Journal of Maintenance in the Addictions
JA  - J MAINTENANCE ADDICT
VL  - 1
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - The Methadone Treatment Quality Assurance System (MTQAS) is a project funded by the National Institute on Drug Abuse (NIDA) to determine the feasibility and usefulness of a performance-based reporting and feedback system in improving narcotic addiction treatment. Six questions are being addressed in the MTQAS project: (a) which outcome indicators can, and should, be used for a performance measurement system; (b) how to identify the unique contribution of program performance to client outcomes; (c) what the operational challenges are that a performance system would involve; (d) whether a performance-based system could be used to modify current Federal methadone regulations; (e) how to structure feedback to programs so that it is of greatest value to them; and (f) whether compliance with current Federal regulations predicts program performance. This paper describes the progress to date with the MTQAS project. Several data collection instruments have been developed and field tested, and methods for adjusting for client characteristics when comparing programs are being investigated. The data collection procedures and feedback of adjusted performance indicators are currently being tested in 25 treatment programs in 15 states and the District of Columbia. Data collected during this phase will be used to address the six questions. Based on the findings from this field test, plans will be developed for the next component of testing the performance-based system.
SN  - 1091-1332
AD  - National Institute on Drug Abuse, Division of Clinical Research, 5600 Fishers Lane, Parklawn Bldg, Room 10A-12, Rockville, MD 20857
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Susman, Elizabeth J.
AU  - Dorn, Lorah D.
AU  - Inoff-Germain, Gale
AU  - Nottelmann, Edith D.
AU  - Chrousos, George P.
T1  - Cortisol Reactivity, Distress Behavior, and Behavioral and Psychological Problems in Young Adolescents: A Longitudinal Perspective.
JO  - Journal of Research on Adolescence (Lawrence Erlbaum)
JF  - Journal of Research on Adolescence (Lawrence Erlbaum)
Y1  - 1997/01//
VL  - 7
IS  - 1
M3  - Article
SP  - 81
EP  - 105
PB  - Taylor & Francis Ltd
SN  - 10508392
AB  - Cortisol levels, observed distress behavior, behavior problems, and symptoms of anxiety and depression are examined in young adolescents. The longitudinal design consists of three times of measurement, at 6-month intervals. We (1) examine covariations among cortisol level and extent of distress behavior in adolescents experiencing a challenging situation, (2) identify intraindividual patterns of change in cortisol level (cortisol reactivity) during the novel and challenging situation at the first time of measurement, (3) examine longitudinal changes in cortisol reactivity and distress behavior, and (4) examine relations between patterns of cortisol reactivity and behavior and psychological problems 1 year later. Significant decreases in distress behavior are found across the l-year period, whereas changes in cortisol level vary by gender. Cortisol level and extent of distress behavior are related under the most novel and challenging circumstance. Intraindividual differences in cortisol reactivity in the challenging situation are identified: some adolescents increase, some do not change, and others decrease in cortisol level. Adolescents in the increase cortisol reactivity group report more behavior problems and symptoms of depression a year later than do adolescents who do not change or decrease in cortisol level. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Research on Adolescence (Lawrence Erlbaum) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADOLESCENCE
KW  - DISTRESS (Psychology)
KW  - HYDROCORTISONE
N1  - Accession Number: 11339703; Susman, Elizabeth J. 1 Dorn, Lorah D. 2 Inoff-Germain, Gale 3 Nottelmann, Edith D. 3 Chrousos, George P. 4; Affiliation:  1: Department of Biobehavioral Health, Health and Human Development Building, The Pennsylvania State University, University Park, PA  16802.  2: University of Pittsburgh  3: National Institute of Mental Health  4: National Institute of Child Health and Human Development; Source Info: 1997, Vol. 7 Issue 1, p81; Subject Term: ADOLESCENCE; Subject Term: DISTRESS (Psychology); Subject Term: HYDROCORTISONE; Number of Pages: 25p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Belland, Robert J.
AU  - Morrison, S. G.
AU  - Carlson, John H.
AU  - Hogan, Daniel M.
T1  - Promoter strength influences phase variation of neisserial <em>opa</em> genes.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997/01//
VL  - 23
IS  - 1
M3  - Article
SP  - 123
EP  - 135
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The <em>opa</em> multigene family of <em>Neisseria gonorrhoeae</em> encodes 11 related outer-membrane proteins which phase vary <em>in vitro</em> and <em>in vivo</em>. Illegitimate recombination within direct pentameric DNA repeats, encoding the signal-peptide region of pre-Opas, leads to switches in expression states. Despite the conserved nature of the variation mechanism, specific genes are expressed at high frequencies in the transition from Opa- to Opa+. The genes which are expressed at elevated frequencies differ from the rest of the family with respect to promoter structure, based on sequence comparisons between the <em>opa</em> genes of strain MS11mk. We have analysed transcription of the <em>opa</em> gene family of <em>N. gonorrhoeae</em> MS11mk, focussing on the different promoters found among the 11 genes to determine whether increased levels of expression are associated with increased phase-variation rates. Primer extension and Northern blotting was used to assess the levels of transcription of three representative <em>opa</em> genes (<em>opaA, B</em> and <em>C</em>) in 'on' and 'off' states. Full-length <em>opa</em> mRNA was detected primarily in strains expressing the homologous gene. Truncated <em>opa</em> mRNA was constitutively expressed from all <em>opa</em> genes regardless of their expression state. Quantitative comparisons in <em>N. gonorrhoeae</em> were complicated by the simultaneous expression of all 11 genes and the cross-reactivity of mRNA probes. Expression levels from the individual promoters were therefore assessed by creating transcriptional and translational <em>lacZ</em> fusions to each of the representative opa promoters which lacked the DNA repeats responsible for variation. The expression levels were compared to the phase-variation rates of translational <em>opa::phoA</em> fusions containing the same promoters in addition to the corresponding coding repeat regions. A strong correlation was found between expression levels from the different promoters and the variation rates at which 'on' variants appeared from an 'off' population (i.e. <em>opaA</em> > <em>opaB</em> > <em>opaC</em>). These results provide an explanation for the favoured expression of specific Opa proteins and indicate that expression of <em>opa</em> genes may be regulated at the level of transcription. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Neisseria gonorrhoeae
KW  - Membrane proteins
KW  - Genes
KW  - Promoters (Genetics)
KW  - Messenger RNA
N1  - Accession Number: 22322393; Belland, Robert J. 1; Email Address: Robert_Belland@NIH.GOV; Morrison, S. G. 1; Carlson, John H. 1; Hogan, Daniel M. 1; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA; Issue Info: Jan1997, Vol. 23 Issue 1, p123; Subject Term: Neisseria gonorrhoeae; Subject Term: Membrane proteins; Subject Term: Genes; Subject Term: Promoters (Genetics); Subject Term: Messenger RNA; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107317553
T1  - Sensitivity and reproducibility of the dual-mode actigraph under controlled levels of activity intensity.
AU  - Leidy NK
AU  - Abbott RD
AU  - Fedenko KM
Y1  - 1997/01//1997 Jan-Feb
N1  - Accession Number: 107317553. Language: English. Entry Date: 19970401. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Physical Activity Readiness Questionnaire (Gordon and Mitchell). NLM UID: 0376404. 
KW  - Functional Assessment
KW  - Movement -- Evaluation
KW  - Functional Assessment -- Equipment and Supplies
KW  - Test-Retest Reliability
KW  - Computers and Computerization
KW  - Descriptive Statistics
KW  - Southeastern United States
KW  - Research Subject Recruitment
KW  - Questionnaires
KW  - McNemar's Test
KW  - Spearman's Rank Correlation Coefficient
KW  - Product Evaluation
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 5
EP  - 11
JO  - Nursing Research
JF  - Nursing Research
JA  - NURS RES
VL  - 46
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The purpose of this study was to test the sensitivity and reproducibility of dual-mode actigraphy as an objective measure of functional performance in healthy adults under controlled levels of activity intensity. Twenty subjects wore the instrument on the nondominant wrist while performing standardized tasks selected to represent day-to-day activities at three levels of intensity (five tasks in each level): light (1-2 metabolic equivalents), moderate (3-4 metabolic equivalents), and heavy (4-6 metabolic equivalents). Upon completion of each intensity level, subjects were asked to rate their level of exertion using Borg's 15-point rating of perceived exertion (RPE) scale. Eighteen subjects repeated the protocol within 7 days. Zero-crossing and time-above-threshold modes successfully differentiated between light and moderate and between light and heavy activity. Reproducibility correlation coefficients (rs) across activity levels were .80 and .66 for the two modes, respectively. Results suggest dual-mode actigraphy may be useful for the study of performance variation and structure in healthy and chronically ill individuals.
SN  - 0029-6562
AD  - Laboratory for the Study of Human Responses to Health and Illness, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 9024418.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107312589
T1  - Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.
AU  - Morrison GB
AU  - Bastian A
AU  - Dela Rosa T
AU  - Diasio RB
AU  - Takimoto CH
Y1  - 1997/01//1997 Jan-Feb
N1  - Accession Number: 107312589. Language: English. Entry Date: 19970301. Revision Date: 20150819. Publication Type: Journal Article; case study; review; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Drug Toxicity
KW  - Fluorouracil -- Adverse Effects
KW  - Oxidoreductases
KW  - Hereditary Diseases
KW  - Deficiency Diseases
KW  - Cancer Patients
KW  - Deficiency Diseases -- Diagnosis
KW  - Drug Toxicity -- Drug Therapy
KW  - Nervous System -- Drug Effects
KW  - Drug Toxicity -- Nursing
KW  - Middle Age
KW  - Male
SP  - 83
EP  - 88
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 24
IS  - 1
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - Purpose/Objectives: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy. Data Sources: Published articles, abstracts, and conference proceedings. Data Synthesis: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU. Diagnosis of DPD deficiency must be confirmed by specialized laboratory tests. The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care, however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma. Conclusions: Early recognition of this serious pharmacogenetic syndrome may allow for the modification of future chemotherapy, thus avoiding further life-threatening toxicities. Implications for Nursing Practice: Nurses must understand the pharmacology, mechanism of action, clinical presentation, potentially lethal risks, and traumatic psychosocial stresses experienced by DPD-deficient patients with cancer receiving 5-FU therapy in order to develop timely interventions and alternative plans of care.
SN  - 0190-535X
AD  - NCI-Navy Medical Oncology Branch of the National Cancer Institute, Bethesda, MD
U2  - PMID: 9007910.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107312589&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107316040
T1  - A scientific basis for the biologic regeneration of synovial joints.
AU  - Luyten FP
Y1  - 1997/01//1997 Jan
N1  - Accession Number: 107316040. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article; proceedings. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101576782. 
KW  - Temporomandibular Joint Diseases -- Therapy
KW  - Joints -- Physiopathology
KW  - National Institutes of Health (U.S.)
KW  - Congresses and Conferences
SP  - 167
EP  - 169
JO  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JF  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JA  - ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDO
VL  - 83
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
SN  - 1079-2104
AD  - Developmental Biology Project, Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MC 20892-1188, Electronic mail: luyten@yoda.nidr.nih.gov
U2  - PMID: 9007942.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107316040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Vissing, Yvonne M.
AU  - Diament, Joseph
T1  - Housing Distress among High School Students.
JO  - Social Work
JF  - Social Work
Y1  - 1997/01//
VL  - 42
IS  - 1
M3  - Article
SP  - 31
EP  - 41
PB  - Oxford University Press / USA
SN  - 00378046
AB  - The word "homelessness" is not a useful term to explain housing problems experienced by high school-aged youths. The term "housing distress" is preferable because it includes both teenagers who are homeless and those who are at risk of homelessness. Many teenagers feel that they have no place where they belong and seek alternative living arrangements for a variety of reasons. Housing distress is a problem for schools because students have difficulties achieving academic success when they have no consistent, safe place to live. To understand how much or how little housing distress is experienced by high school-aged youths, 3,676 high school-aged teenagers were surveyed in nine communities along the seacoast of New Hampshire and southwestern Maine. Between 5 percent and 10 percent of the teenagers surveyed reported that they had been homeless sometime during the past year. Up to 20 percent of the high school students lived in arrangements that could be considered to be distressing and to put them at risk of becoming homeless. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIGH school students
KW  - HOMELESSNESS
KW  - HOUSING
KW  - DISTRESS (Psychology)
KW  - TEENAGERS
KW  - YOUTH
KW  - POVERTY
KW  - UNITED States
KW  - adolescents
KW  - homelessness
KW  - housing distress
KW  - school
KW  - youths
KW  - UNITED States. Bureau of the Census
N1  - Accession Number: 24259079; Vissing, Yvonne M. 1 Diament, Joseph 2; Affiliation:  1: Associate professor of sociology and National Institute of Mental Health Postdoctoral Research Fellow, Salem State College, P.O. Box 547, Durham, NH 03824  2: Director, Odyssey House Foundation, Hampton, NH.; Source Info: Jan97, Vol. 42 Issue 1, p31; Subject Term: HIGH school students; Subject Term: HOMELESSNESS; Subject Term: HOUSING; Subject Term: DISTRESS (Psychology); Subject Term: TEENAGERS; Subject Term: YOUTH; Subject Term: POVERTY; Subject Term: UNITED States; Author-Supplied Keyword: adolescents; Author-Supplied Keyword: homelessness; Author-Supplied Keyword: housing distress; Author-Supplied Keyword: school; Author-Supplied Keyword: youths; Company/Entity: UNITED States. Bureau of the Census; NAICS/Industry Codes: 624229 Other Community Housing Services; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 6319
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107324879
T1  - Housing distress among high school students.
AU  - Vissing YM
AU  - Diament J
Y1  - 1997/01//
N1  - Accession Number: 107324879. Language: English. Entry Date: 20050425. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 2984852R. 
KW  - Home Environment -- New England
KW  - Housing -- Evaluation -- In Adolescence
KW  - Adolescence
KW  - Chi Square Test
KW  - Exploratory Research
KW  - Family Characteristics
KW  - Female
KW  - Homelessness
KW  - Male
KW  - New England
KW  - Sex Factors
KW  - Surveys
KW  - Human
SP  - 31
EP  - 41
JO  - Social Work
JF  - Social Work
JA  - SOC WORK
VL  - 42
IS  - 1
PB  - Oxford University Press / USA
AB  - The word 'homelessness' is not a useful term to explain housing problems experienced by high school-aged youths. The term 'housing distress' is preferable because it includes both teenagers who are homeless and those who are at risk of homelessness. Many teenagers feel that they have no place where they belong and seek alternative living arrangements for a variety of reasons. Housing distress is a problem for schools because students have difficulties achieving academic success when they have no consistent, safe place to live. To understand how much or how little housing distress is experienced by high school-aged youths, 3,676 high school-aged teenagers were surveyed in nine communities along the seacoast of New Hampshire and southwestern Maine. Between 5 percent and 10 percent of the teenagers surveyed reported that they had been homeless sometime during the past year. Up to 20 percent of the high school students lived in arrangements that could be considered to be distressing and to put them at risk of becoming homeless.
SN  - 0037-8046
AD  - National Institute of Mental Health Postdoctoral Research Fellow, Salem State College, PO Box 547, Durham, NH 03824
U2  - PMID: 9009887.
DO  - sw/42.1.31
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107324879&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2009-05404-001
AN  - 2009-05404-001
AU  - Shore, David
AU  - Hsiao, John K.
T1  - Medication-free intervals and schizophrenia research—Editors’ introduction.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1997///
VL  - 23
IS  - 1
SP  - 1
EP  - 1
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
N1  - Accession Number: 2009-05404-001. Partial author list: First Author & Affiliation: Shore, David; Division of Clinical and Treatment Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Ethics; Experimentation; Professional Ethics; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 1. Issue Publication Date: 1997. 
AB  - Early in 1995, in response to growing concerns by patient advocacy groups and clinical researchers, the National Institute of Mental Health (NIMH) sponsored a workshop on Ethical Issues in Schizophrenia Research. In response to the issues raised during that workshop, what follows in this journal is an At Issue dialog, involving two of the world's leading schizophrenia researchers, as a way to present the evidence and discuss potential implications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - schizophrenia
KW  - research
KW  - ethical issues
KW  - 1997
KW  - Experimental Ethics
KW  - Experimentation
KW  - Professional Ethics
KW  - Schizophrenia
KW  - 1997
DO  - 10.1093/schbul/23.1.1
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05404-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-45399-002
AN  - 2015-45399-002
AU  - Vitiello, Benedetto
T1  - Treatment algorithms in child psychopharmacology research.
JF  - Journal of Child and Adolescent Psychopharmacology
JO  - Journal of Child and Adolescent Psychopharmacology
JA  - J Child Adolesc Psychopharmacol
Y1  - 1997///
VL  - 7
IS  - 1
SP  - 3
EP  - 8
CY  - US
PB  - Mary Ann Liebert, Inc.
SN  - 1044-5463
SN  - 1557-8992
AD  - Vitiello, Benedetto, Child and Adolescent Disorders Research Branch, National Institute of Mental Health, Room 18C-17, 5600 Fishers Lane, Rockville, MD, US, 20857
N1  - Accession Number: 2015-45399-002. PMID: 9192537 Partial author list: First Author & Affiliation: Vitiello, Benedetto; Child and Adolescent Disorders Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20170130. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Algorithms; Child Psychiatry; Psychopharmacology; Treatment Effectiveness Evaluation; Treatment. Minor Descriptor: Clinical Trials; Decision Making. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 6. Issue Publication Date: 1997. 
AB  - Clinical trials in child psychiatry research have increased in complexity. Several factors have contributed to this change, including the need to compare multiple therapies, to re-create clinically relevant situations in research, to standardize treatment approaches, to account for the impact of comorbidity, to respond to the needs of individual patients, and to optimize treatment accordingly. To preserve the clinical and internal validity of the experimental interventions vis-à-vis their increasing complexity, researchers have started developing treatment algorithms. These deductive systems for handling data allow us to standardize and incorporate clinical judgment into study designs through the adoption of a stepwise decision making process. Treatment algorithms are different from treatment guidelines. Guidelines are general recommendations that apply to groups of patients with certain characteristics; they are not fully detailed and are created with the expectation that clinical judgment will be applied in individual cases. Algorithms are patient specific, are intended to capture all the relevant details of the clinical situation, and require minimal clinical judgment for their clinical application; they are designed to minimize the role of clinical judgment in research protocols. The entire multistep algorithm is tested in a clinical trial, not the single steps that constitute the algorithm, so proving the efficacy of an algorithm cannot replace a controlled assessment of the individual treatments embedded in the algorithm. Some characteristics, properties, and limitations of algorithms in child psychiatry and psychopharmacology research are presented along with two examples of algorithms currently used in child and adolescent psychopharmacology. Although treatment algorithms seldom have been used in pediatric psychiatry and psychopharmacology, there are indications that their use will increase in the near future and will allow the standardized introduction of clinical judgment into research design. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - clinical judgment
KW  - treatment algorithms
KW  - child psychopharmacology
KW  - pediatric psychiatry
KW  - 1997
KW  - Algorithms
KW  - Child Psychiatry
KW  - Psychopharmacology
KW  - Treatment Effectiveness Evaluation
KW  - Treatment
KW  - Clinical Trials
KW  - Decision Making
KW  - 1997
DO  - 10.1089/cap.1997.7.3
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-45399-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39731-021
AN  - 2015-39731-021
AU  - Chew, Li-Jin
AU  - Fleck, Mark W.
AU  - Wright, Paul
AU  - Scherer, Steven E.
AU  - Mayer, Mark L.
AU  - Gallo, Vittorio
T1  - Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/01//
VL  - 17
IS  - 1
SP  - 227
EP  - 240
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gallo, Vittorio, Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A78, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-39731-021. PMID: 8987751 Partial author list: First Author & Affiliation: Chew, Li-Jin; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Glutamate Receptors; Nerve Growth Factor; Oligodendrocytes; Progenitor Cells. Minor Descriptor: AMPA; mRNA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: Jan, 1997. Publication History: Accepted Date: Oct 22, 1996; Revised Date: Oct 15, 1996; First Submitted Date: Jul 12, 1996. Copyright Statement: Society for Neuroscience. 1996. 
AB  - We analyzed the effects of two growth factors that regulate oligodendrocyte progenitor (O-2A) development on the expression of glutamate receptor (GluR) subunits in cortical O-2A cells. In the absence of growth factors, GluR1 was the AMPA subunit mRNA expressed at the lowest relative level. Basic fibroblast growth factor (bFGF) caused an increase in GluR1 and GluR3 steady-state mRNA levels. Platelet-derived growth factor (PDGF) did not modify the mRNA levels for any of the AMPA subunits but selectively potentiated the effects of bFGF on GluR1 mRNA (4.5-fold increase). The kainate-preferring subunits GluR7, KA1, and KA2 mRNAs were increased by bFGF, but these effects were not modified by cotreatment with PDGF. Nuclear run-on assays demonstrated that PDGF + bFGF selectively increased the rate of GluR1 gene transcription (2.5-fold over control). Western blot analysis showed that GluR1 protein levels were increased selectively (sixfold over control) by PDGF + bFGF. Functional expression was assessed by rapid application of AMPA to cultured cells. AMPA receptor current densities (pA/pF) were increased nearly fivefold in cells treated with PDGF + bFGF, as compared with untreated cells. Further, AMPA receptor channels in cells treated with PDGF + bFGF were more sensitive to voltage-dependent block by intracellular polyamines, as expected from the robust and selective enhancement of GluR1 expression. Our combined molecular and electrophysiological findings indicate that AMPA receptor function can be regulated by growth factor-induced changes in the rate of gene transcription. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - platelet-derived growth factor
KW  - basic fibroblast growth factor
KW  - oligodendrocytes
KW  - gene transcription
KW  - glutamategated channels
KW  - rectification
KW  - 1997
KW  - Glutamate Receptors
KW  - Nerve Growth Factor
KW  - Oligodendrocytes
KW  - Progenitor Cells
KW  - AMPA
KW  - mRNA
KW  - 1997
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39731-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-06949-002
AN  - 1997-06949-002
AU  - Jaquish, C.E.
AU  - Tardif, S.D.
AU  - Cheverud, J.M.
T1  - Interactions between infant growth and survival: Evidence for selection on age-specific body weight in captive common marmosets ( Callithrix jacchus ).
JF  - American Journal of Primatology
JO  - American Journal of Primatology
JA  - Am J Primatol
Y1  - 1997///
VL  - 42
IS  - 4
SP  - 269
EP  - 280
CY  - US
PB  - John Wiley & Sons
SN  - 0275-2565
SN  - 1098-2345
N1  - Accession Number: 1997-06949-002. PMID: 9261508 Partial author list: First Author & Affiliation: Jaquish, C.E.; National Institutes of Health, NHGRI, Ctr for Inherited Disease Research, Baltimore, MD, US. Release Date: 19980301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Environments; Animal Rearing; Animal Sex Differences; Birth Weight; Litter Size. Minor Descriptor: Primates (Nonhuman). Classification: Social & Instinctive Behavior (2440). Population: Animal (20); Male (30); Female (40). Location: US. Methodology: Empirical Study. Page Count: 12. Issue Publication Date: 1997. 
AB  - The objective of this study is to investigate factors influencing infant survival in captive common marmosets. The authors investigated the influence of age-specific weight, sex, litter size, caging, and the presence of helpers on survival to 6 mo of age in 189 common marmoset infants. Infant survival was analyzed using Cox Proportional Hazards regression, and fitness functions were plotted to explore the relationship between survival and growth. Results indicate that weights at birth and 120 days significantly affected future survival probability. Litter size significantly influenced survival prior to 60 days of age with larger litters having poorer survival. Males and females did not have significantly different survival, and the presence of helpers in the group did not influence survival probability. Patterns of survival with respect to age-specific weights suggest stabilizing selection on birth weight and directional selection on weight at 120 days of age. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - birth weight vs weight at 60 vs 120 days & litter size & sex & caging & presence of helpers
KW  - survival to 6 mo
KW  - common marmosets
KW  - 1997
KW  - Animal Environments
KW  - Animal Rearing
KW  - Animal Sex Differences
KW  - Birth Weight
KW  - Litter Size
KW  - Primates (Nonhuman)
KW  - 1997
DO  - 10.1002/(SICI)1098-2345(1997)42:4<269::AID-AJP2>3.0.CO;2-V
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39783-003
AN  - 2015-39783-003
AU  - Muragaki, Yoshihiro
AU  - Chou, Thomas T.
AU  - Kaplan, David R.
AU  - Trojanowski, John Q.
AU  - Lee, Virginia M.-Y.
T1  - Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/01//
VL  - 17
IS  - 2
SP  - 530
EP  - 542
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Lee, Virginia M.-Y., Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, HUP, Maloney Building, Room A009, Philadelphia, PA, US, 19104-4283
N1  - Accession Number: 2015-39783-003. PMID: 8987776 Partial author list: First Author & Affiliation: Muragaki, Yoshihiro; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, US. Release Date: 20160324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Apoptosis; Nerve Growth Factor; Neural Receptors; Phosphorylation; Progenitor Cells. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jan, 1997. Publication History: Accepted Date: Oct 23, 1996; Revised Date: Oct 17, 1996; First Submitted Date: Aug 9, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Neurotrophins act through their cognate receptors to promote the differentiation and/or survival of neuronal progenitor cells, immature neurons, and other cells. Here, we examined the effects of nerve growth factor (NGF) and its cognate receptor (Trk or TrkA) on the survival of a common childhood brain tumor, i.e., medulloblastoma, a tumor that resembles CNS neuroepithelial progenitor cells. To do this, we engineered two human medulloblastoma cell lines (i.e., D283MED and DAOY cells) to express human TrkA using a retroviral expression vector. Surprisingly, NGF-treated medulloblastoma cells expressing the TrkA receptor (D283trk and DAOYtrk cells) grown in the presence or absence of serum underwent massive apoptosis, but similar treatment did not induce apoptosis in wild-type uninfected cells, cells expressing an empty vector, or cells expressing the TrkC receptor. Furthermore, D283MED cells engineered to express the human p75 NGF receptor (D283p75) also did not undergo apoptosis. Significantly, NGF-induced apoptosis in D283trk and DAOYtrk cells can be inhibited by anti-NGF antibodies and by K-252a, an inhibitor of TrkA tyrosine phosphorylation and mimicked by high concentrations of NT3. Because NGF treatment primarily eliminated D283trk cells from the S phase of the cell cycle, this form of NGF-mediated apoptosis is cell cycle-dependent. These findings suggest that a NGF/TrkA signal transduction pathway could activate apoptotic cell death programs in CNS neuroepithelial progenitor cells and in childhood brain tumors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nerve growth factor
KW  - neurotrophins
KW  - medulloblastoma
KW  - TrkA
KW  - apoptosis
KW  - S phase
KW  - 1997
KW  - Apoptosis
KW  - Nerve Growth Factor
KW  - Neural Receptors
KW  - Phosphorylation
KW  - Progenitor Cells
KW  - 1997
U1  - Sponsor: National Institutes of Health, US. Recipients: No recipient indicated
U1  - Sponsor: Alzheimer’s Association. Other Details: Zenith Award. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39783-010
AN  - 2015-39783-010
AU  - Dunwiddie, Thomas V.
AU  - Diao, Lihong
AU  - Kim, Hea O.
AU  - Jiang, Ji-Long
AU  - Jacobson, Kenneth A.
T1  - Activation of hippocampal adenosine A₃ receptors produces a desensitization of A₁ receptor-mediated responses in rat hippocampus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/01//
VL  - 17
IS  - 2
SP  - 607
EP  - 614
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Dunwiddie, Thomas V., Department of Pharmacology, University of Colorado Health Science Center, Box C-236, Denver, CO, US, 80262
N1  - Accession Number: 2015-39783-010. PMID: 8987783 Partial author list: First Author & Affiliation: Dunwiddie, Thomas V.; Program in Neuroscience, University of Colorado Health Science Center, Denver, CO, US. Release Date: 20160324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adenosine; Hippocampus; Neurotransmission; Long-term Potentiation. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 1997. Publication History: Accepted Date: Nov 1, 1996; Revised Date: Oct 28, 1996; First Submitted Date: Mar 18, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The adenosine A₃ receptor is expressed in brain, but the consequences of activation of this receptor on electrophysiological activity are unknown. We have characterized the actions of a selective adenosine A3 receptor agonist, 2-chloro-N⁶-(3-iodobenzyl)-adenosine-5′-N-methyluronamide (Cl-IB-MECA), and a selective A₃ receptor antagonist, 3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate (MRS 1191), in brain slices from rat hippocampus. In the CA1 region, activation of A₃ receptors had no direct effects on synaptically evoked excitatory responses, long-term potentiation, or synaptic facilitation. However, activation of A₃ receptors with Cl-IB-MECA antagonized the adenosine A₁ receptor-mediated inhibition of excitatory neurotransmission. The effects of Cl-IB-MECA were blocked by pretreatment with MRS 1191, which by itself had no effect on A₁ receptor-mediated responses. The presynaptic inhibitory effects of baclofen and carbachol, mediated via GABAB and muscarinic receptors, respectively, were unaffected by Cl-IB-MECA. The maximal response to adenosine was unchanged, suggesting that the primary effect of Cl-IB-MECA was to reduce the affinity of adenosine for the receptor rather than to uncouple it. Similar effects could be demonstrated after brief superfusion with high concentrations of adenosine itself. Under normal conditions, endogenous adenosine in brain is unlikely to affect the sensitivity of A₁ receptors via this mechanism. However, when brain concentrations of adenosine are elevated (e.g., during hypoxia, ischemia, or seizures), activation of A₃ receptors and subsequent heterologous desensitization of A₁ receptors could occur, which might limit the cerebroprotective effects of adenosine under these conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adenosine
KW  - A3 receptor
KW  - A1 receptor
KW  - protein kinase C
KW  - hippocampus
KW  - electrophysiology
KW  - receptor desensitization
KW  - 1997
KW  - Adenosine
KW  - Hippocampus
KW  - Neurotransmission
KW  - Long-term Potentiation
KW  - Rats
KW  - 1997
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, US. Grant: R01 NS 29173. Recipients: No recipient indicated
U1  - Sponsor: US Department of Veterans Affairs, Medical Research Service, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39783-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39783-031
AN  - 2015-39783-031
AU  - Landsend, Alf Sommer
AU  - Amiry-Moghaddam, Mahmood
AU  - Matsubara, Atsushi
AU  - Bergersen, Linda
AU  - Usami, Shin-ichi
AU  - Wenthold, Robert J.
AU  - Ottersen, Ole P.
T1  - Differential localization of δ glutamate receptors in the rat cerebellum: Coexpression with AMPA receptors in parallel fiber–spine synapses and absence from climbing fiber–spine synapses.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/01//
VL  - 17
IS  - 2
SP  - 834
EP  - 842
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ottersen, Ole P., Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105 Blindern, N-0317, Oslo, Norway
N1  - Accession Number: 2015-39783-031. PMID: 8987804 Partial author list: First Author & Affiliation: Landsend, Alf Sommer; Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Release Date: 20160324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neural Receptors; Synapses; AMPA; Interneurons. Minor Descriptor: Purkinje Cells; Rats; Long-term Depression (Neuronal). Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 1997. Publication History: Accepted Date: Nov 5, 1996; Revised Date: Oct 23, 1996; First Submitted Date: Sep 3, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The δ2 glutamate receptors are prominently expressed in Purkinje cells and are thought to play a key role in the induction of cerebellar long-term depression. The synaptic and subsynaptic localization of d receptors in rat cerebellar cortex was investigated with sensitive and high-resolution immunogold procedures. After postembedding incubation with an antibody raised to a C-terminal peptide of δ2, high gold particle densities occurred in all parallel fiber synapses with Purkinje cell dendritic spines, whereas other synapses were consistently devoid of labeling. Among the types of immunonegative synapse were climbing fiber synapses with spines and parallel fiber synapses with dendritic stems of interneurons. At the parallel fiber–spine synapse, gold particles signaling d receptors were restricted to the postsynaptic specialization. By the use of double labeling with two different gold particle sizes, it was shown that d and AMPA GluR2/3 receptors were colocalized along the entire extent of the postsynaptic specialization without forming separate domains. The distribution of gold particles representing δ receptors was consistent with a cytoplasmic localization of the C terminus and an absence of a significant presynaptic pool of receptor molecules. The present data suggest that the δ2 receptors are targeted selectively to a subset of Purkinje cell spines and that they are coexpressed with ionotropic receptors in the postsynaptic specialization. This arrangement could allow for a direct interaction between the two classes of receptor. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - immunogold
KW  - glutamate receptor
KW  - freeze substitution
KW  - colocalization
KW  - synapse
KW  - cerebellum
KW  - 1997
KW  - Neural Receptors
KW  - Synapses
KW  - AMPA
KW  - Interneurons
KW  - Purkinje Cells
KW  - Rats
KW  - Long-term Depression (Neuronal)
KW  - 1997
U1  - Sponsor: Norwegian Research Council, Norway. Recipients: No recipient indicated
U1  - Sponsor: J. E. Isberg’s Fund. Recipients: No recipient indicated
U1  - Sponsor: European Union, Biomed Program, Europe. Grant: BMH4-CT960851. Recipients: No recipient indicated
U1  - Sponsor: Sasakawa Foundation. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107316212
T1  - Chapter 1. Introduction and summary of the dietary and nutritional methods and findings in the Multiple Risk Factor Intervention Trial.
AU  - Cutler JA
AU  - Stamler J
Y1  - 1997/01/02/Jan97 Supplement
N1  - Accession Number: 107316212. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article; research. Supplement Title: Jan97 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Blood Pressure
KW  - Cholesterol
KW  - Coronary Disease -- Prevention and Control
KW  - Diet
KW  - Smoking Cessation
KW  - Cardiovascular Risk Factors
KW  - Clinical Trials
KW  - Human
KW  - Intervention Trials
SP  - 184S
EP  - 90S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 65
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
SN  - 0002-9165
AD  - Prevention and Demonstration Research Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 8988936.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rice, C. H.
AU  - Checkoway, H.
AU  - Dosemeci, M.
AU  - Stewart, P.
AU  - Blair, A.
T1  - Effects of Exposure Estimation Procedures on the Evaluation of Exposure-Response Relationships for Silicosis.
JO  - Annals of Occupational Hygiene
JF  - Annals of Occupational Hygiene
Y1  - 1997/01/02/1997 Inhaled Particles VIII
VL  - 41
M3  - Article
SP  - 485
EP  - 490
SN  - 00034878
AB  - The article presents a research which examines the impact of exposure estimation procedures on the assessment of exposure-response relationships for silicosis. It highlights the limited number of environmental measurements available as well as identifies the methods used in estimating exposure for jobs during time periods with few or no sample results. The research calculates odds ratios for silicosis in an imputation algorithm. The materials and methods for the research are provided.
KW  - Silica -- Physiological effect
KW  - Health risk assessment
KW  - Occupational hazards
KW  - Industrial toxicology
KW  - Silicosis
N1  - Accession Number: 90325999; Rice, C. H. 1; Checkoway, H. 2; Dosemeci, M. 3; Stewart, P. 3; Blair, A. 3; Affiliations: 1: University of Cincinnati, Dept. of Environmental Health PO Box 670056, Cincinnati, OH 45267-0056; 2: University of Washington Seattle, Washington; 3: National Cancer Institute Bethesda, Maryland, U.S.A.; Issue Info: 1997 Inhaled Particles VIII, Vol. 41, p485; Thesaurus Term: Silica -- Physiological effect; Thesaurus Term: Health risk assessment; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial toxicology; Subject Term: Silicosis; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Udey, M. C.
T1  - Cadherins and Langerhans cell immunobiology.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1997/01/02/Jan1997 Supplement
VL  - 107
M3  - Article
SP  - 6
EP  - 8
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Langerhans cells represent the epidermal contingent of a family of potent accessory cells termed 'dendritic cells'. Langerhans cells (and perhaps related cells in the dermis) are thought to be required for immune responses directed against foreign antigens and neoantigens that are encountered in skin. The `life cycle' of the Langerhans cell is characterized by at least two distinct stages. Langerhans cells in epidermis (the 'sentinels') can ingest particulates and process antigens efficiently, but are weak stimulators of unprimed T cells. In contrast, Langerhans cells that have been induced to migrate to lymph nodes after contact with antigen in epidermis (the 'messengers') are not phagocytic and have limited antigen-processing capabilities, but are potent stimulators of naïve T cells. If Langerhans cells are to fulfil both their `sentinel' and 'messenger' roles, they must be able to persist in epidermis for considerable periods, and also be able to exit epidermis in a controlled fashion after exposure to antigen. Thus, regulation of Langerhans cell-keratinocyte adhesion represents a key control point in Langerhans cell trafficking and function. Langerhans cells express E-cadherin, a homophilic adhesion molecule that is prominently represented in epithelia. Keratinocytes also express this adhesion molecule, and E-cadherin clearly mediates adhesion of murine Langerhans cells to keratinocytes in vitro. We presume that E-cadherin is involved in the localization of Langerhans cells in epidermis. Murine thymocytes also express E-cadherin early in the course of their development, and it is likely that E-cadherin plays an as yet uncharacterized role in thymocyte-thymic epithelial cell adhesion and in T-cell development. Recently, it has also been demonstrated that some cutaneous T-cell lymphoma cell lines are E- cadherin+, so E-cadherin may also mediate clinically important leucocyte-epithelial interactions in disease states. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LANGERHANS cells
KW  - DENDRITIC cells
KW  - IMMUNITY
KW  - T cells
KW  - LYMPH nodes
KW  - KERATINOCYTES
KW  - adhesion
KW  - cadherins
KW  - immnunobiology
KW  - Langerhans cells skin
N1  - Accession Number: 15950229; Udey, M. C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jan1997 Supplement, Vol. 107, p6; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: IMMUNITY; Subject Term: T cells; Subject Term: LYMPH nodes; Subject Term: KERATINOCYTES; Author-Supplied Keyword: adhesion; Author-Supplied Keyword: cadherins; Author-Supplied Keyword: immnunobiology; Author-Supplied Keyword: Langerhans cells skin; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Trent, J. M.
AU  - Bittner, M.
AU  - Zhang, J.
AU  - Wiltshire, R.
AU  - Ray, M.
AU  - Su, Y.
AU  - Gracia, E.
AU  - Meltzer, P.
AU  - de Risi, J.
AU  - Penland, L.
AU  - Brown, P.
T1  - Use of microgenomic technology for analysis of alterations in DNA copy number and gene expression in malignant melanoma.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1997/01/02/Jan1997 Supplement
VL  - 107
M3  - Article
SP  - 33
EP  - 40
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Chromosome abnormalities in human malignancies have identified the genomic location of several important growth-regulatory genes, including cellular oncogenes and tumour suppressor genes. Melanomas are characterized by recurring chromosome alterations, and it is important to identify those genes whose altered expression may be causally related to melanocytic transformation. This short report presents an overview- of strategies used which combine the materials and technologies of the Human Genome Project with clinically directed studies of melanoma biology. The Human Genome Project combines various technologies, including cytogenetic, physical mapping, genetic mapping and DNA sequencing, in order to identify all of the human genes, but especially the 4000 estimated to contribute to human disease. This report focuses first on advances in genome technology that provide information on chromosome rearrangements and DNA copy number changes. This includes a discussion of chromosome microdissection as well as the microexcision of tissue specimens to gain insights into chromosome regions altered in association with melanocytc transformation. Next, there is a brief discussion of the generation and characterization of subtracted cDNA sublibraries which allow the identification of genes uniquely expressed in association with the transformed phenotype of human melanoma cells. Finally, we briefly discuss the feasibility of using a recently developed system for parallel examination of multiple genes based upon robotic printing of cDNAs on glass slides, and simultaneous two-colour fluorescence hybridization to study the expression patterns of cDNAs for their association with melanoma tumour suppression. The combination of these varied molecular technologies may provide insights into previously unrecognized genes involved causally in the pathobiology of this important neoplasm, and may provide new targets for clinical intervention. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOMA
KW  - GENE expression
KW  - DNA
KW  - GENOMES
KW  - HUMAN gene mapping
KW  - CHROMOSOMAL rearrangement
KW  - gene expression
KW  - genomics
KW  - melanoma
N1  - Accession Number: 15950250; Trent, J. M. 1 Bittner, M. 1 Zhang, J. 1 Wiltshire, R. 1 Ray, M. 1 Su, Y. 1 Gracia, E. 1 Meltzer, P. 1 de Risi, J. 1 Penland, L. 2 Brown, P. 2; Affiliation:  1: Laboratory of Cancer Genetics, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland, USA.  2: Department of Biochemistry, Stanford University Medical Center, Stanford, California, USA.; Source Info: Jan1997 Supplement, Vol. 107, p33; Subject Term: MELANOMA; Subject Term: GENE expression; Subject Term: DNA; Subject Term: GENOMES; Subject Term: HUMAN gene mapping; Subject Term: CHROMOSOMAL rearrangement; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: genomics; Author-Supplied Keyword: melanoma; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morgan, R. A.
T1  - Gene therapy for HIV infection.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1997/01/02/Jan1997 Supplement
VL  - 107
M3  - Article
SP  - 41
EP  - 44
PB  - Wiley-Blackwell
SN  - 00099104
AB  - WIV-1 is the causative agent of acquired immune deficiency syndrome (AIDS) and is a major international health concern. The limited effectiveness of current antiviral therapies has led to the search for alternative treatments. One emerging field of medical treatment is termed human gene therapy. In principle, human gene therapy calls for the engineering of the cells from a medical patient with an agent that can potentially result in a therapeutic benefit to the patient. It has been suggested that gene therapy technology may he applied as an anti-HIV-1 agent. The term Intracellular immunization' was suggested for strategies that work within a potential HIV-1 target cell to inhibit the productive infection of that cell by HIV-1. Various strategies based on this intracellular approach have been proposed and include the use of antisense, and transdominant HIV proteins. Bosh of these approaches can inhibit HIV-1 in vitro and a clinical trial has been proposed to test their effectiveness in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE therapy
KW  - HIV infections
KW  - MEDICAL care
KW  - AIDS (Disease)
KW  - HEALTH
KW  - CLINICAL trials
KW  - AIDS antisense RNA
KW  - retroviral vector
KW  - transdominant Rev
N1  - Accession Number: 15950256; Morgan, R. A. 1; Affiliation:  1: Clinical Gene Therapy Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jan1997 Supplement, Vol. 107, p41; Subject Term: GENE therapy; Subject Term: HIV infections; Subject Term: MEDICAL care; Subject Term: AIDS (Disease); Subject Term: HEALTH; Subject Term: CLINICAL trials; Author-Supplied Keyword: AIDS antisense RNA; Author-Supplied Keyword: retroviral vector; Author-Supplied Keyword: transdominant Rev; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
ID  - 107265569
T1  - Internet anatomy 101. Accessing information on the World Wide Web.
AU  - Sikorski R
AU  - Peters R
AU  - Sikorski, R
AU  - Peters, R
Y1  - 1997/01/08/
N1  - Accession Number: 107265569. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: directories; website. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Internet
KW  - Information Resources
SP  - 171
EP  - 172
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 277
IS  - 2
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - National Cancer Institute, Bethesda, Md, USA
AD  - National Cancer Institute, Bethesda, MD; e-mail: rss@nchgr.nih.gov
U2  - PMID: 8990346.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107149881
T1  - Intake of vitamins E, C, and A and risk of lung cancer: the NHANES I Epidemiologic Followup Study.
AU  - Yong L
AU  - Brown CC
AU  - Schatzkin A
AU  - Dresser CM
AU  - Slesinski MJ
AU  - Cox CS
AU  - Taylor PR
Y1  - 1997/01/14/
N1  - Accession Number: 107149881. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: National Center for Health Statistics of the Centers for Disease Control and Prevention, the National Institute on Aging, the National Cancer Institute, and other institutes of the National Institutes of Health. NLM UID: 7910653. 
KW  - Food Intake
KW  - Ascorbic Acid
KW  - Vitamin A
KW  - Vitamin E
KW  - Lung Neoplasms -- Epidemiology
KW  - Prospective Studies
KW  - Cox Proportional Hazards Model
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Interviews
KW  - Questionnaires
KW  - Linear Regression
KW  - Descriptive Statistics
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - P-Value
KW  - Smoking
KW  - Fruit
KW  - Vegetables
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 231
EP  - 243
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 146
IS  - 3
PB  - Oxford University Press / USA
AB  - The relation between the dietary intake of vitamins E, C, and A (estimated by a 24-hour recall) and lung cancer incidence was examined in the First National Health and Nutrition Examination Survey Epidemiologic Followup Study cohort of 3,968 men and 6,100 women, aged 25-74 years. During a median follow-up period of 19 years (from 1971-1975 to 1992), 248 persons developed lung cancer. Adjusted for potential confounders using Cox proportional hazards regression methods with age as the underlying time variable, the relative risk of lung cancer for subjects in the highest quartile of vitamin C intake compared with those in the lowest quartile was 0.66 (95% confidence interval (CI) 0.45-0.96). For vitamin A intake, a protective effect was observed only for its fruit and vegetable component (carotenoids) among current smokers (relative risk = 0.49, 95% CI 0.29-0.84), but this was modified by the intensity of smoking (a statistically significant effect (relative risk = 0.33, 95% CI 0.13-0.84) was observed only for those in the lowest tertile of pack-years of smoking). The vitamin E intake-lung cancer relation was modified by the intensity of smoking with a significant protective effect confined to current smokers in the lowest tertile of pack-years of smoking (relative risk = 0.36, 95% CI 0.16-0.83). Overall, there was no additional protective effect of supplements of vitamins E, C, and A beyond that provided through dietary intake. When vitamin E, vitamin C, and carotenoid intakes were examined in combination, a strong protective effect was observed for those in the highest compared with those in the lowest quartile of all three intakes (relative risk = 0.32, 95% CI 0.14-0.74). These data provide support for a protective role of dietary vitamins E and C and of carotenoids against lung cancer risk but with a modification in effects by the intensity of cigarette exposure. While smoking avoidance is the most important behavior to reduce lung cancer risk, the daily consumption of a variety of fruits and vegetables that provides a combination of these nutrients and other potential protective factors may offer the best dietary protection against lung cancer.
SN  - 0002-9262
AD  - Cancer Prevention Studies Branch, DCPC, National Cancer Institute, EPN, Room 211, 6130 Executive Blvd, MSC 6326, Rockville, MD 20852
U2  - PMID: 9247007.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Puri, Pier Lorenzo
AU  - Avantaggiati, Maria Laura
AU  - Balsano, Clara
AU  - Sang, Nianli
AU  - Graessmann, Adolf
AU  - Giordano, Antonio
AU  - Levrero, Massimo
T1  - p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/01/15/
VL  - 16
IS  - 2
M3  - Article
SP  - 369
EP  - 383
SN  - 02614189
AB  - The nuclear phosphoprotein p300 is a new member of a family of 'co-activators' (which also includes the CREB binding protein CBP), that directly modulate transcription by interacting with components of the basal transcriptional machinery. Both p300 and CBP are targeted by the adenovirus E1A protein, and binding to p300 is required for E1A to inhibit terminal differentiation in both keratinocytes and myoblasts. Here we demonstrate that, in differentiating skeletal muscle cells, p300 physically interacts with the myogenic basic helix—loop—helix (bHLH) regulatory protein MyoD at its DNA binding sites. During muscle differentiation, MyoD plays a dual role: besides activating muscle-specific transcription, it induces permanent cell cycle arrest by up-regulating the cyclin-dependent kinase inhibitor p21. We show that p300 is involved in both these activities. Indeed, E1A mutants lacking the ability to bind p300 are greatly impaired in the repression of E-box-driven transcription, and p300 overexpression rescues the wild-type E1A-mediated repression. Moreover, p300 potentiates MyoD- and myogenin-dependent activation of transcription from E-box-containing reporter genes. We also provide evidence, obtained by microinjection of anti-p300 anti-bodies, that p300 is required for MyoD-dependent cell cycle arrest in either myogenic cells induced to differentiate or in MyoD-converted (3H10T1/2 fibroblasts, but is dispensable for maintenance of the postmitotic state of myotubes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - MUSCLES
KW  - GENES
KW  - CYCLIN-dependent kinases
KW  - PROTEINS
KW  - CELL cycle
KW  - cell cycle arrest
KW  - e1a
KW  - myod
KW  - p300
KW  - skeletal muscle
N1  - Accession Number: 13005275; Puri, Pier Lorenzo 1,2 Avantaggiati, Maria Laura 3 Balsano, Clara 1,4 Sang, Nianli 5 Graessmann, Adolf 6 Giordano, Antonio 5 Levrero, Massimo 1,7; Affiliation:  1: Laboratory of Genetic Expression, Fondazione Andrea Cesalpino  2: Instituto I Clinica Medica, Policlinico Umberto I, Università degli Studi di Roma La Sapienza, Rome, Italy  3: DCBOC/Path, National Cancer Institute, National Institutes of Health, Bethesda, USA  4: Dipartimento di Medicina Interna, Università degli Studi di L'Aquila, L'Aquila, Italy  5: Sbarro Institute for Cancer Research and Molecular Medicine and Department of Microbiology/Immunology, Thomas Jefferson University, Philadelphia, PA, USA  6: Institut for Molekularbiologie und Biochemie der Freien Universitat Berlin, Berlin, Germany  7: Instituto di Medicina Interna, Università di Cagliari, Cagliari, Italy; Source Info: 1/15/97, Vol. 16 Issue 2, p369; Subject Term: CELLS; Subject Term: MUSCLES; Subject Term: GENES; Subject Term: CYCLIN-dependent kinases; Subject Term: PROTEINS; Subject Term: CELL cycle; Author-Supplied Keyword: cell cycle arrest; Author-Supplied Keyword: e1a; Author-Supplied Keyword: myod; Author-Supplied Keyword: p300; Author-Supplied Keyword: skeletal muscle; Number of Pages: 15p; Document Type: Article
L3  - 10.1093/emboj/16.2.369
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sharma, Yogendra
AU  - Chandani, Sushil
AU  - Sukhaswami, Malladi Balasubrahmanyam
AU  - Uma, Lakshmipathy
AU  - Balasubramanian, Dorairajan
AU  - Fairwell, Thomas
T1  - Modified helix-loop-helix motifs of calmodulin.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/01/15/
VL  - 243
IS  - 1/2
M3  - Article
SP  - 42
EP  - 48
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The four calcium-binding sites, called the helix-loop-helix, or the EF-hand motifs, of calmodulin differ in their ion-binding affinities; this has been thought to arise due to the variations in the sequences of the loop regions where the ion binds. We focus attention here on the role of the flanking helical regions on the calcium-binding affinities. Peptides were synthesized in a manner that simulates the E and F helical flanks of site 4 (the strongest calcium-binding site of the calmodulin) to sandwich the loop sequences of sites 1, 2, 3 and 4 so as to produce peptides named 414, 424, 434 and 444, as well as using the helical flanks of site I (the weakest site) to produce peptides 111, 121, 131 and 141. Calcium binding was monitored using the calcium-nimic dye Stains-all (4,4,4',5'-dibenzo-3,3'-diethyl-9-methyl-thiacarbocyanine bromide). Binding abilities were seen to increase several-fold when the E and F helices of site 1 were replaced by those of site 4 (i.e., l11-414). In contrast, the intensity of circular dichroism induced in the absorption bands of the bound achiral dye decreased significantly when the helical flanks of site 4 were replaced with those of site 1 (i.e., 444-141). The helical flanks of site 4 impart greater binding ability to a given loop region, while the helical flanks of site I tend to weaken it. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALMODULIN
KW  - HELIX-loop-helix motifs
KW  - TRANSCRIPTION factors
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
KW  - 4,4,4',5'-dibenzo-3,3'-diethyl-9-methyl-thiacarbocyanine bromide
KW  - calmodulin
KW  - helix-loop-helix motif
N1  - Accession Number: 13675754; Sharma, Yogendra 1 Chandani, Sushil 2 Sukhaswami, Malladi Balasubrahmanyam 1 Uma, Lakshmipathy 1 Balasubramanian, Dorairajan 1 Fairwell, Thomas 3; Affiliation:  1: Centre for Cellular and Molecular Biology, Hyderabad, India  2: RSCHS, Sikh Village Extn., Secunderabad, India  3: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda; Source Info: 1/15/97, Vol. 243 Issue 1/2, p42; Subject Term: CALMODULIN; Subject Term: HELIX-loop-helix motifs; Subject Term: TRANSCRIPTION factors; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: 4,4,4',5'-dibenzo-3,3'-diethyl-9-methyl-thiacarbocyanine bromide; Author-Supplied Keyword: calmodulin; Author-Supplied Keyword: helix-loop-helix motif; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costell, Mercedes
AU  - Mann, Karlheinz
AU  - Yamada, Yoshihiko
AU  - Timpl, Rupert
T1  - Characterization of recombinant perlecan domain I and its substitution by glycosaminoglycans and oligosaccharides.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/01/15/
VL  - 243
IS  - 1/2
M3  - Article
SP  - 115
EP  - 121
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Recombinant mouse perlecan domain I (173 residues) was produced in transfected embryonic kidney cells and purified from the culture medium on DEAE-cellulose. It was shown to be modified by glycosaminoglycans and could be partially separated into two protein pools which were either substituted with heparan snlfate (fragment IA) or. to a smaller extent (20%), with chondroitin/dermatan sulfate or a mixture of both glycosaminoglycans (fragment IB). The average molecular mass of the glycosaminoglycans was about 8-10 kDa and thus, smaller than in tissue-derived perlecans. Sequence and carbohydrate analyses localized the heparan sulfate attachment site to three Set residues within SGD consensus sequences. Furthermore, the N-terminal part of fragment IA contained six Thr/Ser residues substituted by branched galactosamine-containing oligosaccharides and an N-substituted Ash residue. Fragment I was also shown to contain unique immunological epitopes which are not dependent on glycosaminoglycans and are shared by tissue-derived perlecan. Circular dichroism demonstrated a distinct a helix (20%) and β structure (60%)in fragment IA. consistent with predictions of a novel SEA protein module located in the C-terminal part of domain I. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL lamina
KW  - PROTEOGLYCANS
KW  - RECOMBINANT proteins
KW  - GLYCOSAMINOGLYCANS
KW  - OLIGOSACCHARIDES
KW  - BIOCHEMISTRY
KW  - basement membrane
KW  - protein module
KW  - proteoglycan
N1  - Accession Number: 13677429; Costell, Mercedes 1 Mann, Karlheinz 1 Yamada, Yoshihiko 2 Timpl, Rupert 1; Affiliation:  1: Max-Planck-Institut für Biochemie, Martinsried, Germany  2: National Institute of Dental Research, National Institutes of Health, Bethesda; Source Info: 1/15/97, Vol. 243 Issue 1/2, p115; Subject Term: BASAL lamina; Subject Term: PROTEOGLYCANS; Subject Term: RECOMBINANT proteins; Subject Term: GLYCOSAMINOGLYCANS; Subject Term: OLIGOSACCHARIDES; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: basement membrane; Author-Supplied Keyword: protein module; Author-Supplied Keyword: proteoglycan; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107265608
T1  - Molecular genetics in clinical practice I: sequencing the human genome.
AU  - Collins FS
Y1  - 1997/01/15/
N1  - Accession Number: 107265608. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; algorithm; CEU; exam questions; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Human Genome Project
KW  - Genes
KW  - Genetic Markers
KW  - Genetic Techniques
KW  - Education, Continuing (Credit)
KW  - DNA
KW  - Chromosomes
KW  - Hereditary Diseases -- Familial and Genetic
KW  - Hereditary Diseases -- Diagnosis
KW  - Genetic Screening
KW  - Gene Therapy
SP  - 35
EP  - 54
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 32
IS  - 1
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - National Center for Human Genome Research, National Institutes of Health, Bethesda, Md
U2  - PMID: 9006582.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265637
T1  - The problem patient. Neutrophilia and organomegaly in two patients with cancer... leukemoid reaction.
AU  - Wright JJ
AU  - Hoffmeister KJ
AU  - Cotelingam JD
AU  - Allegra CJ
Y1  - 1997/01/15/
N1  - Accession Number: 107265637. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; case study; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Leukocyte Disorders -- Diagnosis
KW  - Neutrophils -- Pathology
KW  - Diagnosis, Differential
KW  - Leukemia -- Diagnosis
KW  - Sarcoma -- Complications
KW  - Stomach Neoplasms -- Complications
KW  - Diagnosis, Laboratory
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Outpatients
SP  - 135
EP  - 142
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 32
IS  - 1
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - National Cancer Institute and National Naval Center, Bethesda, Md
U2  - PMID: 9064302.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107265637&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107150065
T1  - Effects of social support and personal coping resources on mortality in older age: the Longitudinal Aging Study Amsterdam.
AU  - Penninx BWJ
AU  - van Tilburg T
AU  - Kriegsman DMW
AU  - Deeg DJH
AU  - Boeke AJP
AU  - van Eijk JTM
Y1  - 1997/01/17/
N1  - Accession Number: 107150065. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: General Self-Efficacy Scale (Sherer et al); Pearlin Mastery Scale. Grant Information: Netherlands Ministry of Welfare, Health, and Sports. NLM UID: 7910653. 
KW  - Support, Psychosocial -- In Old Age
KW  - Coping -- In Old Age
KW  - Mortality -- In Old Age
KW  - Prospective Studies
KW  - Interviews
KW  - P-Value
KW  - Scales
KW  - Cox Proportional Hazards Model
KW  - Research Instruments
KW  - Univariate Statistics
KW  - Correlation Coefficient
KW  - Chi Square Test
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 510
EP  - 519
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 146
IS  - 6
PB  - Oxford University Press / USA
AB  - This study focuses on the role of social support and personal coping resources in relation to mortality among older persons in the Netherlands. Data are from a sample of 2,829 noninstitutionalized people aged between 55 and 85 years who took part in the Longitudinal Aging Study Amsterdam in 1992-1995. Social support was operationally defined by structural, functional, and perceived aspects, and personal coping resources included measures of mastery, self-efficacy, and self-esteem. Mortality data were obtained during a follow-up of 29 months, on average. Cox proportional hazards regression models revealed that having fewer feelings of loneliness and greater feelings of mastery are directly associated with a reduced mortality risk when age, sex, chronic diseases, use of alcohol, smoking, self-rated health, and functional limitations are controlled for. In addition, persons who received a moderate level of emotional support (odds ratio (OR) = 0.49, 95% confidence interval (CI) 0.33-0.72) and those who received a high level of support (OR = 0.68, 95% CI 0.47-0.98) had reduced mortality risks when compared with persons who received a low level of emotional support. Receipt of a high level of instrumental support was related to a higher risk of death (OR = 1.74, 95% CI 1.12-2.69). Interaction between disease status and social support or personal coping resources on mortality could not be demonstrated.
SN  - 0002-9262
AD  - Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Gateway Bldg, Suite 3C-309, Bethesda, MD 20892
U2  - PMID: 9290512.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107253144
T1  - The treatment of chronic viral hepatitis.
AU  - Hoofnagle JH
AU  - Di Bisceglie AM
Y1  - 1997/01/30/
N1  - Accession Number: 107253144. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Hepatitis B -- Drug Therapy
KW  - Hepatitis C -- Drug Therapy
KW  - Chronic Disease -- Drug Therapy
SP  - 347
EP  - 356
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 336
IS  - 5
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 9011789.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Susser, Ezra
AU  - Valencia, Elie
AU  - Conover, Sarah
AU  - Felix, Alan
AU  - Wei-Yann Tsai
AU  - Wyatt, Richard Jed
T1  - Preventing Recurrent Homelessness among Mentally Ill Men: A "Critical Time" Intervention after Discharge from a Shelter.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/02//
VL  - 87
IS  - 2
M3  - Article
SP  - 256
EP  - 262
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents a study which examines a strategy to prevent homelessness among individuals with severe mental illness, by providing a bridge between institutional and community care. This randomized clinical trial tested an approach to prevent homelessness among mentally ill individuals. Although it is widely believed that mentally disabled persons merit care and accommodation in the community, we frequently fail in providing it. In the United States, men and women with chronic mental illness such as schizophrenia have a 25& to 50% risk of becoming homeless, which is about 10 to 20 times the risk of homelessness for the general population. This study demonstrates that it is possible to intervene to prevent homelessness among individuals with severe mental illness. The view that these patients suffer homelessness and other deprivations because they cannot be reached may be unwarranted. Furthermore, the intervention that proved effective in this study was neither costly nor complex.
KW  - PEOPLE with mental disabilities
KW  - HOMELESS persons
KW  - CLINICAL trials
KW  - HOMELESSNESS
KW  - MENTAL health
KW  - PATHOLOGICAL psychology
KW  - HYPOTHESIS
N1  - Accession Number: 9704025950; Susser, Ezra 1,2 Valencia, Elie Conover, Sarah 1 Felix, Alan 1 Wei-Yann Tsai 1 Wyatt, Richard Jed 3; Affiliation:  1: Columbia University Schools of Medicine and Public Health, New York State Psychiatric Institute and the Presbyterian Hospital Psychiatric Service, New York, NY.  2: Center for Urban Epidemiologic Studies, New York Academy of Medicine.  3: Neuropsychiatry Branch, National Institute of Mental Health, Bethesda, Md.; Source Info: Feb1997, Vol. 87 Issue 2, p256; Subject Term: PEOPLE with mental disabilities; Subject Term: HOMELESS persons; Subject Term: CLINICAL trials; Subject Term: HOMELESSNESS; Subject Term: MENTAL health; Subject Term: PATHOLOGICAL psychology; Subject Term: HYPOTHESIS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 6076
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nebeling, Linda C.
AU  - Forman, Michele R.
AU  - Graubard, Barry I.
AU  - Snyder, Richard A.
T1  - The Impact of Lifestyle Characteristics on Carotenoid Intake in the United States: The 1987 Nation Health Interview Survey.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/02//
VL  - 87
IS  - 2
M3  - Article
SP  - 268
EP  - 271
PB  - American Public Health Association
SN  - 00900036
AB  - The article focuses on a study, which compares carotenoid intake in the United States by demographic and lifestyles variables to identify potential high-risk subgroups for disease. Adults 18 to 99 years of age completed a food frequency questionnaire in the 1987 National Health Survey, and mean carotenoid intakes were estimated. Results of the study show that carotenoid intakes were lower among Whites, smokers, nondrinkers, adults between 18 to 39 years of age, frequent restaurant consumers, and less educated persons. Authors conclude that the benefits of a carotenoid-rich diet should be communicated to high-risk subgroups.
KW  - CAROTENOIDS
KW  - HEALTH surveys
KW  - PUBLIC health -- United States
KW  - AGE groups
KW  - QUESTIONNAIRES
KW  - LIFESTYLES
KW  - DEMOGRAPHY
KW  - UNITED States
N1  - Accession Number: 9704025952; Nebeling, Linda C. 1 Forman, Michele R. 1 Graubard, Barry I. 1 Snyder, Richard A. 2; Affiliation:  1: Division of Cancer Control and Prevention, National Cancer Institute, Bethesda.  2: Information Management Services, Silver Spring, Md.; Source Info: Feb1997, Vol. 87 Issue 2, p268; Subject Term: CAROTENOIDS; Subject Term: HEALTH surveys; Subject Term: PUBLIC health -- United States; Subject Term: AGE groups; Subject Term: QUESTIONNAIRES; Subject Term: LIFESTYLES; Subject Term: DEMOGRAPHY; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article; Full Text Word Count: 3295
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107289145
T1  - Infectious disease mortality among infants in the United States, 1983 through 1987.
AU  - Read JS
AU  - Troendle JF
AU  - Klebanoff MA
Y1  - 1997/02//
N1  - Accession Number: 107289145. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074. 
KW  - Communicable Diseases -- Mortality -- In Infancy and Childhood
KW  - Chi Square Test
KW  - Odds Ratio
KW  - Logistic Regression
KW  - Confidence Intervals
KW  - Data Analysis Software
KW  - Record Review
KW  - Prospective Studies
KW  - Communicable Diseases -- Mortality
KW  - Infant Mortality
KW  - Maternal Age
KW  - United States
KW  - Prenatal Care
KW  - Infant, Newborn
KW  - Infant
KW  - Male
KW  - Female
KW  - Human
SP  - 192
EP  - 198
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 87
IS  - 2
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVE: The purpose of this study was to determine the relative importance of infectious disease as a cause of infant mortality in the United States and to identify characteristics at birth associated with subsequent infectious disease mortality. METHODS: Birth and infant death certificate data from the National Center for Health Statistics (NCHS) 1983 through 1987 Linked Birth\ Infant Death Data Sets were analyzed. RESULTS: Infection was the underlying cause of death for over 16000 infants, representing the fourth leading cause of mortality in this cohort. Almost 90% of infectious disease deaths during infancy were due to noncongenital infections, and the majority of these deaths occurred during the postneonatal period. Low birthweight, preterm birth, and male gender were independently associated with postneonatal mortality due to noncongenital infection. CONCLUSIONS: NCHS should revise its classification system for causes of infant mortality to incorporate an 'Infectious Diseases' category. Future research should be directed toward clarifying the low birthweight-infectious disease mortality relationship and determining the degree to which infection-related infant deaths might be prevented by existing vaccines or improved access to health care.
SN  - 0090-0036
AD  - Division of Epidemiology, Statistics, and Preventive Research, National Institute of Child Health and Human Development (NICHO), Bethesda, Md
U2  - PMID: 9103096.
DO  - 10.2105/AJPH.87.2.192
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107289262
T1  - The impact of lifestyle characteristics on carotenoid intake in the United States: the 1987 National Health Interview Survey.
AU  - Nebeling LC
AU  - Forman MR
AU  - Graubard BI
AU  - Snyder RA
Y1  - 1997/02//
N1  - Accession Number: 107289262. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: 1987 National Health Interview Survey (NHIS). NLM UID: 1254074. 
KW  - Carotenoids -- Administration and Dosage
KW  - Linear Regression
KW  - Data Analysis Software
KW  - Age Factors
KW  - Blacks
KW  - Comparative Studies
KW  - Surveys
KW  - Questionnaires
KW  - Risk Factors
KW  - Socioeconomic Factors
KW  - United States
KW  - Whites
KW  - Research Instruments
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 268
EP  - 271
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 87
IS  - 2
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study compared mean carotenoid intake in the United States by demographic and lifestyle variables to identify potential high-risk subgroups for disease. METHODS: Adults 18 to 99 years of age (n = 22 080) completed a food frequency questionnaire in the 1987 National Health Interview Survey, and mean carotenoid intakes were estimated. RESULTS: Carotenoid intakes were lower among Whites (vs Blacks), current smokers (vs nonsmokers), nondrinkers (vs drinkers), adults 18 to 39 years of age (vs those 40 to 69 years of age), frequent restaurant consumers (vs those who ate at home), and less educated (vs college-educated) persons. CONCLUSIONS: The benefits of a carotenoid-rich diet should be communicated to high-risk subgroups.
SN  - 0090-0036
AD  - National Cancer Institute, EPN, Suite 211, 6130 Executive Blvd, MSC 7326, Bethesda, MD 20892-7326
U2  - PMID: 9103108.
DO  - 10.2105/AJPH.87.2.268
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107326080
T1  - The medical gender gap: why female patients are so often misdiagnosed... and what to do about it.
AU  - Swedo S
Y1  - 1997/02//
N1  - Accession Number: 107326080. Language: English. Entry Date: 19970601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 9891730. 
KW  - Sexism
KW  - Professional-Patient Relations
KW  - Diagnostic Errors
KW  - Physicians
KW  - Male
KW  - Female
SP  - 13
EP  - 14
JO  - Bottom Line Health
JF  - Bottom Line Health
JA  - BOTTOM LINE HEALTH
VL  - 11
IS  - 2
CY  - Greenwich, Connecticut
PB  - Health Confidential
SN  - 1092-0129
AD  - National Institute of Mental Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107344827
T1  - Semantic, phonological, and perceptual changes following left and right intracarotid injection (Wada) with a low amytal dosage.
AU  - Fedio P
AU  - August A
AU  - Patronas N
AU  - Sato S
AU  - Kufta C
Y1  - 1997/02//1997 Feb
N1  - Accession Number: 107344827. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 8218014. 
KW  - Barbiturates
KW  - Language Disorders -- Chemically Induced
KW  - Perceptual Disorders -- Chemically Induced
KW  - Phonetics
KW  - Semantics
KW  - Carotid Arteries
KW  - Language Disorders -- Diagnosis
KW  - Memory Disorders -- Chemically Induced
KW  - Memory Disorders -- Diagnosis
KW  - Perceptual Disorders -- Diagnosis
KW  - Injections, Intraarterial
KW  - Barbiturates -- Administration and Dosage
KW  - Barbiturates -- Adverse Effects
KW  - Repeated Measures
KW  - Analysis of Variance
KW  - Adult
KW  - Male
KW  - Human
SP  - 98
EP  - 117
JO  - Brain & Cognition
JF  - Brain & Cognition
JA  - BRAIN COGNIT
VL  - 33
IS  - 1
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
SN  - 0278-2626
AD  - Department of Neuropsychology, National Institute of Neurological Disorders and Stroke and Clinical Center, National Institutes of Health
U2  - PMID: 9056278.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107243016
T1  - Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute registry of alpha1-Antitrypsin deficiency.
AU  - McElvaney NG
AU  - Stoller JK
AU  - Buist AS
AU  - Prakash UBS
AU  - Brantly ML
AU  - Schluchter MD
AU  - Crystal RD
Y1  - 1997/02//1997 Feb
N1  - Accession Number: 107243016. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: NO1-HR-86036 from the National Heart, Lung and Blood Institute, National Institutes of Health. NLM UID: 0231335. 
KW  - Alpha 1-Antitrypsin
KW  - Registries, Disease
KW  - T-Tests
KW  - Fisher's Exact Test
KW  - Bronchodilator Agents -- Therapeutic Use
KW  - Forced Expiratory Volume
KW  - Multiple Logistic Regression
KW  - National Institutes of Health (U.S.)
KW  - Genetics
KW  - Prospective Studies
KW  - Funding Source
KW  - United States
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 394
EP  - 403
JO  - CHEST
JF  - CHEST
JA  - CHEST
VL  - 111
IS  - 2
CY  - Glenview, Illinois
PB  - American College of Chest Physicians
AB  - OBJECTIVE: alpha 1-Antitrypsin (alpha 1-AT) deficiency is a hereditary disorder characterized by a high risk for the development of emphysema at an early age. In 1988, the National Heart, Lung and Blood Institute, National Institutes of Health, initiated a registry of individuals with alpha 1-AT deficiency to help define the natural history and clinical course of this disorder. This article describes demographic and clinical characteristics of subjects enrolled in the Registry at baseline. DESIGN: Prospective longitudinal natural history study. SETTING: Thirty-seven clinical centers in the United States (36 centers) and Canada (one center). PATIENTS: There were 1,129 subjects 18 years of age or older with severe deficiency of alpha 1-AT, defined as having serum alpha 1-AT levels < or = 11 micromol/L confirmed by a Central Phenotyping Laboratory, or a ZZ or ZNull genotype identified by genomic DNA analysis. RESULTS: Most enrollees were symptomatic white subjects in their fourth to sixth decade, with a ZZ phenotype, a history of having smoked cigarettes, and pulmonary function tests demonstrating a pattern consistent with emphysema. Interestingly, only a small percentage were current smokers on enrollment, suggesting that this population is amenable to smoking cessation. A subgroup of individuals in the Registry with relatively normal lung function were younger, more likely to have never smoked and more likely to have come to medical attention owing to a family history of alpha 1-AT deficiency rather than symptomatic involvement. CONCLUSIONS: These results emphasize the need for increased awareness and early detection of alpha 1-AT deficiency. In this endeavor, dissemination of the information contained in the Registry to health-care professionals and the general population, along with initiation of appropriate preventative measures before significant lung damage has occurred, could have considerable benefits for individuals with this condition.
SN  - 0012-3692
AD  - Pulmonary-Critical Care Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md
U2  - PMID: 9041988.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Nagel, Deborah E.
AU  - Putnam, Frank W.
AU  - Noll, Jennie G.
AU  - Trickett, Penelope K.
T1  - DISCLOSURE PATTERNS OF SEXUAL ABUSE AND PSYCHOLOGICAL FUNCTIONING AT A 1-YEAR FOLLOW UP.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1997/02//
VL  - 21
IS  - 2
M3  - Article
SP  - 137
EP  - 147
SN  - 01452134
AB  - This study describes the disclosure processes of a sample of 68 sexually abused girls, with a focus on the manner in which abuse was revealed--on purpose, accidentally, or resulting from a precipitating event. This categorization is a more descriptive conceptualization of the disclosure process than has been proposed or assessed in previous studies. The circumstances surrounding disclosure are found to be related to long term psychological functioning. Children who disclosed accidentally were younger, experienced abuse for shorter durations, and received the most therapy. At follow-up, children who purposely disclosed had greater anxiety and greater difficulties coping. Discussion focuses on ways in which identifying and encouraging the least traumatic methods of disclosure would contribute to better outcomes for victims of sexual abuse. (English) [ABSTRACT FROM AUTHOR]
AB  - Este estudio describe los procesos de denuncia en una muestra de 68 muchachas sexualmente abusadas, enfocando la manera en que el abuso fue denunciado: intencional, accidental o como resultado de un evento desencadenante. Estas categorías son una conceptualización más descriptiva del proceso de denuncia que las que han sido propuestas o evaluadas en estudios anteriores. Se encontró que, a largo plazo, las circunstancias que rodean la denuncia están relacionadas con el funcionamiento psicológico. Los niños que hacían su denuncia de forma accidental eran de menos edad, la experiencia de abuso era de menos duración y recibieron más terapia. En el estudio de seguimiento, los niños que denunciaron intencionalmente tenían mayor ansiedad y mayores dificultades para recuperarse. La discusión enfoca cómo las formas de identificar y recomendar los métodos menos traumáticos de denuncia, contribuirían a mejorar las consecuencias del abuso sexual en las víctimas. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Cette étude décrit les processus de dévoilement dans un échantillon de 68 filles abusées sexuellement, en mettant l'accent sur la manière dont l'abus a été révélé-délibérément, accidentellement, ou en réaction à un événement qui a précipité le dévoilement. Cette division en cétegories correspond à une conceptualisation plus descriptive du processus de dévoilement que celui qui a été proposé ou évalué dans des études précédentes. Les enfants qui ont dévoilé l'abus accidentellement étaient plus jeunes, ont vécu l'abus pour des périodes plus courtes et ont été plus en thérapie. Lors du suivi, les enfant qui ont délibérément dévoilé l'abus présentaient plus d'anxiété et plus de difficultés à s'adapter. La discussion se concentre sur les façons d'identifier et d'encourager les méthodes de dévoilement les moins traumatisantes pour les victimes d'abus sexuels. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD sexual abuse -- Reporting
KW  - ABUSED children
KW  - GIRLS -- Crimes against
KW  - CHILD psychology
KW  - ANXIETY
KW  - 1-year follow-up
KW  - Child sexual abuse
KW  - Disclosure
KW  - Psychological functioning
N1  - Accession Number: 9709263085; Nagel, Deborah E. 1 Putnam, Frank W. 1 Noll, Jennie G. 1 Trickett, Penelope K. 2; Affiliation:  1: Unit on Developmental Traumatology, National Institute of Mental Health, Bethesda, MD, USA  2: Department of Psychology, University of Southern California, Los Angeles, CA, USA; Source Info: Feb97, Vol. 21 Issue 2, p137; Subject Term: CHILD sexual abuse -- Reporting; Subject Term: ABUSED children; Subject Term: GIRLS -- Crimes against; Subject Term: CHILD psychology; Subject Term: ANXIETY; Author-Supplied Keyword: 1-year follow-up; Author-Supplied Keyword: Child sexual abuse; Author-Supplied Keyword: Disclosure; Author-Supplied Keyword: Psychological functioning; Number of Pages: 11p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107201198
T1  - Undiagnosed diabetes or impaired glucose tolerance and cardiovascular risk.
AU  - Eastman RC
AU  - Cowie CC
AU  - Harris MI
Y1  - 1997/02//
N1  - Accession Number: 107201198. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Glucose Intolerance -- Complications
KW  - Diabetes Mellitus, Type 2
KW  - Cardiovascular Risk Factors
KW  - Hyperglycemia
SP  - 127
EP  - 128
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 20
IS  - 2
CY  - Alexandria, Virginia
PB  - American Diabetes Association
SN  - 0149-5992
AD  - Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
U2  - PMID: 9118758.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107201206
T1  - Ambulatory medical care for non-Hispanic Whites, African-Americans, and Mexican-Americans with NIDDM in the U.S.
AU  - Cowie CC
AU  - Harris MI
Y1  - 1997/02//
N1  - Accession Number: 107201206. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Partially supported by a contract (NO1-DK-1-2282) from the National Institute of Diabetes and Digestive and Kidney Diseases. NLM UID: 7805975. 
KW  - Diabetes Mellitus, Type 2
KW  - Ambulatory Care -- United States
KW  - Blacks -- United States
KW  - Hispanics -- United States
KW  - Whites -- United States
KW  - Race Factors
KW  - Questionnaires
KW  - Patient Education
KW  - Cross Sectional Studies
KW  - Data Analysis, Statistical
KW  - United States
KW  - Sampling Methods
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 142
EP  - 147
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 20
IS  - 2
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To assess whether medical care for diabetes is different among non-Hispanic whites, African-Americans, and Mexican-Americans with NIDDM. RESEARCH DESIGN AND METHODS: A questionnaire was administered to a representative U.S. sample of 2,170 noninstitutionalized adults with NIDDM. Information was obtained on physician visits, hyperglycemic therapy, monitoring of glycemic control, screening for and monitoring of complications, and diabetes education. RESULTS: About 90% of subjects had a regular diabetes physician, and the physician visit rate was similar by race (median of four visits per year). African-Americans were more likely to be treated with insulin (51.9%) than non-Hispanic whites (35.9%, P < 0.0001) and Mexican-Americans (46.2%). Among insulin-treated subjects, African-Americans were less likely to use multiple daily insulin injections (35.1 vs. 53.8% of non-Hispanic whites [P < 0.0001] and 50.5% of Mexican-Americans [P = 0.027]) and were less likely to self-monitor their blood glucose at least once per day (14.0 vs. 29.8% of non-Hispanic whites [P < 0.0001] and 29.0% of Mexican-Americans). The rates of visits to specialists for diabetes complications, physician testing of blood glucose, and screening for hypertension, retinopathy, and foot problems were not substantially different among the three race/ethnic groups. A higher proportion of African-Americans (43.3%) than non-Hispanic whites (31.5%, P < 0.0001) and Mexican-Americans (25.6%, P = 0.001) had received patient education; however, the median number of hours of instruction was lower for African-Americans. CONCLUSIONS: The frequency of diabetes care is similar among non-Hispanic whites, African-Americans, and Mexican-Americans. The major differences relate to methods of glycemic control and patient education.
SN  - 0149-5992
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Natcher Bldg., Rm 5AN24A, 45 Center Dr., Bethesda, MD 20892-6600
U2  - PMID: 9118761.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Gajewski, Kathleen
AU  - Yongsok Kim
AU  - Young Mi Lee
AU  - Olson, Eric N.
AU  - Schulz, Robert A.
T1  - D-mef2 is a target for Tinman activation during Drosophila heart development.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/02//2/1/97
VL  - 16
IS  - 3
M3  - Article
SP  - 515
EP  - 522
SN  - 02614189
AB  - The NK-type homeobox gene tinman and the MADS box gene D-mef2 encode transcription factors required for the development and differentiation of the Drosophila heart, and closely related genes regulate cardiogenesis in vertebrates. Genetic analyses indicate that tinman and D-mef2 act at early and late steps, respectively, in the cardiogenic lineage. However, it is unknown whether regulatory interactions exist between these developmental control genes. We show that D-mef2 expression in the developing Drosophila heart requires a novel upstream enhancer containing two Tinman binding sites, both of which are essential for enhancer function in cardiac muscle cells. Transcriptional activity of this cardiac enhancer is dependent on tinman function, and ectopic Tinman expression activates the enhancer outside the cardiac lineage. These results define the only known in vivo target for transcriptional activation by Tinman and demonstrate that D-mef2 lies directly downstream of tinman in the genetic cascade controlling heart formation in Drosophila. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOMEOBOX genes
KW  - DROSOPHILA
KW  - HEART
KW  - TRANSCRIPTION factors
KW  - BINDING sites (Biochemistry)
KW  - PROTEINS
KW  - BIOCHEMISTRY
KW  - cardiogenic factors
KW  - d-mef2
KW  - heart
KW  - tinman
KW  - transcriptional enhancer
N1  - Accession Number: 13005305; Gajewski, Kathleen 1 Yongsok Kim 2 Young Mi Lee 2 Olson, Eric N. 3 Schulz, Robert A. 1; Affiliation:  1: Department of Biochemistry and Molecular Biology, The University of Texas M.D.Anderson Cancer Center, Houston, TX  2: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD  3: Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, The University of Texas Southwestern Medical Center, Dalla, USA; Source Info: 2/1/97, Vol. 16 Issue 3, p515; Subject Term: HOMEOBOX genes; Subject Term: DROSOPHILA; Subject Term: HEART; Subject Term: TRANSCRIPTION factors; Subject Term: BINDING sites (Biochemistry); Subject Term: PROTEINS; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: cardiogenic factors; Author-Supplied Keyword: d-mef2; Author-Supplied Keyword: heart; Author-Supplied Keyword: tinman; Author-Supplied Keyword: transcriptional enhancer; Number of Pages: 8p; Document Type: Article
L3  - 10.1093/emboj/16.3.515
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nihrane, A.
AU  - Silver, J.
T1  - Spontaneous priming for anti-viral envelope cytotoxic T lymphocytes in mice transgenic for a murine leukaemia virus envelope gene (<em>Fv4</em>).
JO  - Immunology
JF  - Immunology
Y1  - 1997/02//
VL  - 90
IS  - 2
M3  - Article
SP  - 219
EP  - 228
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Compared with non-transgenic controls, mice beating an Fv4 murine retroviral env transgene resist infection and do not become immunosuppressed when inoculated with Friend virus (FV). When immunized with FV antigens in the absence of infectious virus, they make antibodies and cytotoxic lymphocytes (CTL) to FV comparably to non-transgenic controls. Unimmunized transgenic mice were found to have CTL precursors, which could be activated by in vitro stimulation, specific for viral (and self) envelope protein (Env). This ‘spontaneous priming’ for antiviral CTL is surprising because the transgene Env is present on the surface of thymocytes and in serum from before birth. Our experiments demonstrate that T cells reactive with self-thymic and serum antigens sometimes avoid clonal elimination or inactivation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - T cells
KW  - VIRAL antigens
KW  - ANTIGENS
KW  - FRIEND virus
KW  - MOUSE leukemia viruses
KW  - LYMPHOCYTES
KW  - TRANSGENES
KW  - IMMUNOLOGY
N1  - Accession Number: 14073240; Nihrane, A. 1 Silver, J. 1; Affiliation:  1: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda. MD. USA; Source Info: Feb97, Vol. 90 Issue 2, p219; Subject Term: T cells; Subject Term: VIRAL antigens; Subject Term: ANTIGENS; Subject Term: FRIEND virus; Subject Term: MOUSE leukemia viruses; Subject Term: LYMPHOCYTES; Subject Term: TRANSGENES; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105822452
T1  - Treatment of refractory chronic lymphocytic leukemia with fludarabine phosphate via the group C protocol mechanism of the National Cancer Institute: five-year follow-up report.
AU  - Sorensen JM
AU  - Vena DA
AU  - Fallavollita A
AU  - Chun HG
AU  - Cheson BD
AU  - Sorensen, J M
AU  - Vena, D A
AU  - Fallavollita, A
AU  - Chun, H G
AU  - Cheson, B D
Y1  - 1997/02//
N1  - Accession Number: 105822452. Language: English. Entry Date: 20080307. Revision Date: 20161120. Publication Type: journal article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Adenosine -- Analogs and Derivatives
KW  - Fludarabine -- Therapeutic Use
KW  - Adenosine -- Administration and Dosage
KW  - Adenosine -- Adverse Effects
KW  - Adenosine -- Therapeutic Use
KW  - Adult
KW  - Clinical Trials
KW  - Drug Administration Schedule
KW  - Female
KW  - Fludarabine -- Administration and Dosage
KW  - Fludarabine -- Adverse Effects
KW  - Human
KW  - Male
KW  - Middle Age
KW  - National Institutes of Health (U.S.)
KW  - Prognosis
KW  - Prospective Studies
KW  - Protocols
KW  - Survival Analysis
KW  - Treatment Outcomes
KW  - United States
SP  - 458
EP  - 465
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 2
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To provide fludarabine to physicians for the management of patients with advanced refractory chronic lymphocytic leukemia (CLL) and to determine the response rate and duration, toxicity, and survival with this agent.Patients and Methods: This phase II protocol was open to all eligible patients whose local physicians obtained written permission from the National Cancer Institute (NCI) to register patients onto this protocol. Of 791 national and international enrolled patients, 724 with a median age of 65 years received fludarabine, of which 703 were assessable for response.Results: Thirty-two percent of assessable patients responded (95% confidence interval [CI], 29% to 36%), with 21 patients (3%) obtaining a complete response and 205 (29%) a partial response. The median duration of response was 13.1 months and the median survival time from registration was 12.6 months. Age, performance status (PS), and Rai stage correlated with survival (P < .01). Grade 4 hematologic toxicity was reported in 43% and was associated with infection in 22%. Neurotoxicity (primarily grade 1 motor dysfunction) was reported in 14% patients and correlated with age.Conclusion: This study describes the toxicity and activity of fludarabine in refractory CLL in a setting that more closely resembles clinical practice than most published trials. The low response rate may be related to advanced stage (89% Rai high-risk), disease-related symptoms (63% had B symptoms), and/or degree of prior treatment. Other contributing factors inherent in a group C treatment protocol included lack of central pathology review, variable supportive care, and a tendency to use this mechanism at a later stage in the disease.
SN  - 0732-183X
AD  - Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
AD  - Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 9053466.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105822486
T1  - Paclitaxel by 96-hour continuous infusion in combination with cisplatin: a phase I trial in patients with advanced lung cancer.
AU  - Georgiadis MS
AU  - Schuler BS
AU  - Brown JE
AU  - Kieffer LV
AU  - Steinberg SM
AU  - Wilson WH
AU  - Takimoto CH
AU  - Kelley MJ
AU  - Johnson BE
AU  - Georgiadis, M S
AU  - Schuler, B S
AU  - Brown, J E
AU  - Kieffer, L V
AU  - Steinberg, S M
AU  - Wilson, W H
AU  - Takimoto, C H
AU  - Kelley, M J
AU  - Johnson, B E
Y1  - 1997/02//
N1  - Accession Number: 105822486. Language: English. Entry Date: 20080307. Revision Date: 20161120. Publication Type: journal article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Carcinoma, Non-Small-Cell Lung -- Drug Therapy
KW  - Lung Neoplasms -- Drug Therapy
KW  - Adult
KW  - Aged
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Antineoplastic Agents -- Pharmacokinetics
KW  - Antineoplastic Agents, Combined -- Adverse Effects
KW  - Carcinoma, Non-Small-Cell Lung -- Blood
KW  - Cisplatin -- Administration and Dosage
KW  - Clinical Trials
KW  - Female
KW  - Infusions, Intravenous
KW  - Injections, Intravenous
KW  - Lung Neoplasms -- Blood
KW  - Male
KW  - Middle Age
KW  - Paclitaxel -- Administration and Dosage
KW  - Paclitaxel -- Pharmacokinetics
KW  - Prognosis
KW  - Treatment Outcomes
KW  - Human
SP  - 735
EP  - 743
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 2
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To determine the maximum-tolerated dose (MTD) of paclitaxel administered by 96-hour continuous infusion in combination with cisplatin, to determine if the addition of granulocyte colony-stimulating factor (G-CSF) permits significant paclitaxel dose escalation, and to assess the toxicity and preliminary activity of this combination in patients with advanced lung cancer.Patients and Methods: Fifty patients with untreated lung cancer were enrolled: 42 had advanced non-small-cell lung cancer (NSCLC) and eight had extensive-stage small-cell lung cancer (SCLC). Patients received paclitaxel doses of 100 to 180 mg/m2/96 hours and cisplatin doses of 60 to 80 mg/m2 as a single 30-minute bolus injection at the end of the paclitaxel infusion.Results: Two of six patients experienced dose-limiting neutropenia at a dose of paclitaxel 140 mg/m2/96 hours and cisplatin 80 mg/m2. With G-CSF support, one of three patients experienced both dose-limiting mucositis and fatal neutropenic sepsis at a dose of paclitaxel 180 mg/m2/96 hours and cisplatin 80 mg/m2. Significant peripheral neuropathy developed in five patients and occurred after six or more cycles of therapy. Thirty-three of 42 patients with NSCLC had measurable disease; the objective response rate was 55%, with two complete responses and 16 partial responses. For all 42 patients with NSCLC, the median time to progression and median survival duration were 5 months and 10 months, respectively. The actuarial 1-year survival rate was 41%. Of eight SCLC patients, four responded to therapy, and the median survival duration for all SCLC patients was 11 months.Conclusion: The MTD without G-CSF is paclitaxel 120 mg/m2/96 hours and cisplatin 80 mg/m2, and the MTD with G-CSF is paclitaxel 160 mg/m2/96 hours and cisplatin 80 mg/m2. Infusional paclitaxel with cisplatin is well tolerated and active in patients with advanced NSCLC.
SN  - 0732-183X
AD  - National Cancer Institute-Navy Medical Oncology Branch, National Cancer Institute, Bethesda, MD, USA
AD  - National Cancer Institute-Navy Medical Oncology Branch, National Cancer Institute, Bethesda, MD, USA. georgiam@navmed.nci.nih.gov
U2  - PMID: 9053499.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Fujimoto, Wataru
AU  - Nakanishi, Gen
AU  - Arata, Jirô
AU  - Jetten, Anton M.
T1  - Differential Expression of Human Cornifin α and β in Squamous Differentiating Epithelial Tissues and Several Skin Lesions.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/02//
VL  - 108
IS  - 2
M3  - Article
SP  - 200
EP  - 204
SN  - 0022202X
AB  - Cornifins/small proline-rich proteins (SPRRs) belong to a family of proline-rich proteins that function as cornified envelope precursors. We report here an immunohistochemical analysis of human cornifin-α and -β expression in several stratified squamous epithelia. In normal human skin, cornifin-α was expressed in the granular layer of the epidermis of palmoplantar skin, in the inner lining cells of the follicular infundibulum, and in the inner root sheath of the hair follicle. It was also expressed in the upper squamous layers of the oral, esophageal, and vaginal epithelia. Cornifin-β was detected in oral, esophageal, and vaginal epithelia, but not in normal skin. Immunoblot analysis revealed quantitative differences in cornifin-α expression in skin from different regions. Studies of specimens from various skin diseases showed that (i) cornifin-α was upregulated in inflammatory skin diseases, hyperplastic lesions, and in well-differentiated squamous cell carcinomas (SCCs), (ii) the expression of cornifin-β was absent in inflammatory skin but was detected in highly differentiated keratinocytes in well-differentiated SCCs of the skin and some other hyperproliferative skin lesions, and in SCCs of the oral mucosa and esophagus. Northern blot analysis revealed that cornifin-α ,MRNA was present in all the squamous epithelial tissues studied, whereas cornifin-β mRNA was expressed in oral mucosal epithelia and verrucous carcinoma of the skin but neither in normal nor in psoriatic skin. These results indicate that (i) the amount of cornifin α/SPRR1 expression in normal human skin depends on the body region, (ii) cornifin-α/SPRR1, but not cornifin-β, contributes to the integrity of the hair follicle, and (iii) the expression of cornifin-β is induced in some hyperplastic skin diseases only when the keratinocytes undergo extensive squamous differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESOPHAGUS -- Diseases
KW  - SKIN diseases
KW  - KERATINOCYTES
KW  - ORAL mucosa
KW  - CANCER
KW  - IMMUNOHISTOCHEMISTRY
KW  - cornified envelope
KW  - cornifin
KW  - involucrin
KW  - keratinocyte
KW  - SPRR
N1  - Accession Number: 12334240; Fujimoto, Wataru 1 Nakanishi, Gen 1 Arata, Jirô 1 Jetten, Anton M. 2; Affiliation:  1: Department of Dermatology, Okayama University Medical School, 2-5-1 Shikata, Okayama 700, Japan.  2: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina, U.S.A.; Source Info: Feb97, Vol. 108 Issue 2, p200; Subject Term: ESOPHAGUS -- Diseases; Subject Term: SKIN diseases; Subject Term: KERATINOCYTES; Subject Term: ORAL mucosa; Subject Term: CANCER; Subject Term: IMMUNOHISTOCHEMISTRY; Author-Supplied Keyword: cornified envelope; Author-Supplied Keyword: cornifin; Author-Supplied Keyword: involucrin; Author-Supplied Keyword: keratinocyte; Author-Supplied Keyword: SPRR; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12334240
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12334240&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - The Book of David: How Preserving Families Can Cost Children's Lives (Book).
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1997/02//
VL  - 59
IS  - 1
M3  - Book Review
SP  - 235
EP  - 236
SN  - 00222445
AB  - Reviews the book "The Book of David: How Preserving Families Can Cost Children's Lives," by Richard Gelles.
KW  - FAMILIES
KW  - NONFICTION
KW  - GELLES, Richard
KW  - BOOK of David, The (Book)
N1  - Accession Number: 9703244250; Lamb, Michael E. 1; Affiliation:  1: National Institute of Child health and human Development.; Source Info: Feb97, Vol. 59 Issue 1, p235; Subject Term: FAMILIES; Subject Term: NONFICTION; Reviews & Products: BOOK of David, The (Book); People: GELLES, Richard; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 735
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107241750
T1  - Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study... this paper was presented as part of a symposium at the 1994 annual meeting of the Gerontological Society of America.
AU  - Harris TB
AU  - Kiel D
AU  - Roubenoff R
AU  - Langlois J
AU  - Hannan M
AU  - Havlik R
AU  - Wilson P
Y1  - 1997/02//2/ 1/1997
N1  - Accession Number: 107241750. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Growth Substances
KW  - Health Behavior
KW  - Body Composition
KW  - Body Weight
KW  - Aging -- Physiology
KW  - Cross Sectional Studies
KW  - Prospective Studies
KW  - Nutritional Status
KW  - Massachusetts
KW  - Data Analysis Software
KW  - P-Value
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 133
EP  - 139
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVES: We examined correlates of insulin-like growth factor-I (IGF-I), an indicator of growth hormone levels, to identify factors associated with higher levels of IGF-I in old age. DESIGN: Nested study of cross-sectional correlates and early-life predictors of IGF-I level. SETTING: A longitudinal cohort study, the Framingham Heart Study. PARTICIPANTS: A total of 790 men and women (mean age 78.5, range 72-94), who had weight, waist and hip circumferences measured at the time of IGF-I measurement. MEASUREMENTS: Association of IGF-I with weight, fat distribution, functional status, nutritional indicators, and past health behaviors was assessed. We also examined IGF-I in relation to body composition derived from dual energy X-ray absorptiometry. RESULTS: IGF-I levels declined with age in both men and women. However, low IGF-I did not show expected associations with low lean mass and increased body fat. Current functional status and grip strength were not associated with IGF-I Low IGF-I was associated with weight loss in men; the strongest associations were with indicators of poorer nutritional status in both men and women. Levels of IGF-I in old age did not vary by past health behaviors. CONCLUSION: Although IGF-I declined with age, these data from the Framingham Heart Study did not show expected cross-sectional associations of weight, body fat, and lean mass. The strongest associations were between IGF-I and nutritional indicators. These results suggest caution may be warranted with regard to use of IGF-I as an indicator of growth hormone.
SN  - 0002-8614
AD  - National Institute on Aging, Epidemiology, Demography and Biometry Program, Gateway Building, Room 3C-309, 7201 Wisconsin Ave, Bethesda, MD 20892-9205
U2  - PMID: 9033509.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107241750&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107302503
T1  - Detection and staging of renal cancer.
AU  - Choyke PL
Y1  - 1997/02//1997 Feb
N1  - Accession Number: 107302503. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9422762. 
KW  - Kidney Neoplasms -- Diagnosis
KW  - Kidney Neoplasms -- Classification
KW  - Magnetic Resonance Imaging
KW  - Neoplasm Staging
KW  - Magnetic Resonance Imaging -- Methods
KW  - Tomography, X-Ray Computed
SP  - 29
EP  - 47
JO  - Magnetic Resonance Imaging Clinics of North America
JF  - Magnetic Resonance Imaging Clinics of North America
JA  - MAGN RESON IMAGING CLIN NORTH AM
VL  - 5
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Although MR imaging is not a first-line modality for detecting renal cancers, it is useful when computed tomography or ultrasound are limited by artifacts or when contrast media cannot be administered because of renal dysfunction or allergy. MR imaging is commonly used in staging renal cancers, particularly in assessing the presence and extent of inferior vena caval thrombus. Additionally, MR imaging can be useful in detecting adenopathy, hepatic metastases, direct organ invasion, and bony metastases to the spine. Thus, MR imaging has an established role in the detection and staging of renal cancers. Copyright (c) 1997 by W.B. Saunders Company
SN  - 1064-9689
AD  - The Clinical Center, Building 10, Room 1C660, Department of Radiology, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 8995123.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107302503&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107323001
T1  - Has there been a real drop in the number of expected cancer cases in the United States?
AU  - Fritz AG
Y1  - 1997/02//1997 Feb
N1  - Accession Number: 107323001. Language: English. Entry Date: 19970501. Revision Date: 20150711. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Allied Health; Computer/Information Science; Peer Reviewed; USA. NLM UID: 9212861. 
KW  - Neoplasms -- Epidemiology
KW  - Incidence -- Trends
KW  - Time Factors
KW  - Neoplasms -- Diagnosis
KW  - Registries, Disease
KW  - Data Collection
SP  - 15
EP  - 28
JO  - Topics in Health Information Management
JF  - Topics in Health Information Management
JA  - TOP HEALTH INF MANAGE
VL  - 17
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - In 1993, after more than 20 years of increases, there was an observed decrease in the number of new cancer cases reported and in the overall cancer incidence rate in areas covered by the Surveillance, Epidemiology, and End Results Program based at the National Cancer Institute. Most of the decrease is attributed to a reduction in the number of prostate cancers diagnosed in 1993, a result of the introduction of a new screening tool for prostate cancer in the late 1980s. The article examines a number of possible reasons for the decrease in both overall cancer rates and prostate cancer rates and discusses whether the decrease is real or a statistical anomaly. (C) 1997 Aspen Publishers, Inc.
SN  - 1065-0989
AD  - Cancer Statistics Branch, National Cancer Institute, Bethesda, MD
U2  - PMID: 10165384.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107323001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2008-13559-001
AN  - 2008-13559-001
AU  - Glass, M.
AU  - Brotchie, J. M.
AU  - Maneuf, Y. P.
T1  - Modulation of neurotransmission by cannabinoids in the basal ganglia.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1997/02//
VL  - 9
IS  - 2
SP  - 199
EP  - 203
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Maneuf, Y. P., Division of Neuroscience, School of Biological Sciences, Unlversity of Manchester, Manchester, United Kingdom, M13 9PT
N1  - Accession Number: 2008-13559-001. PMID: 9058040 Partial author list: First Author & Affiliation: Glass, M.; Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD, United Kingdom. Other Publishers: Blackwell Publishing. Release Date: 20101115. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Basal Ganglia; Cannabinoids; Neural Receptors; Neurotransmission. Minor Descriptor: Glutamic Acid; Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10); Animal (20). References Available: Y. Page Count: 5. Issue Publication Date: Feb, 1997. Publication History: Accepted Date: Sep 30, 1996; Revised Date: Aug 28, 1996; First Submitted Date: Jun 13, 1996. Copyright Statement: European Neuroscience Association
AB  - The regional distribution of the CB1 cannabinoid receptor in the basal ganglia has been well characterized in the rat, primate and human brain, and shows very similar distributions in the different species. Cannabinoid receptor localization has been primarily determined by autoradiographic labeling with and more recently with the cannabinoid antagonist SR141716A. Within the basal ganglia, cannabinoid receptors occur both pre- and postsynaptically. In both the rat and the human brain, the output nuclei of the basal ganglia exhibit extremely high levels of cannabinoid receptor. In order to develop an understanding of the role of cannabinoids in the basal ganglia, it is first necessary to understand the localization of cannabinoid receptors in relation to the predominant neurotransmitters and neurotransmitter receptors of the basal ganglia. Elucidation of the functional implications of cannabinoids in basal ganglion physiology/pathophysiology may be one of the keys to explaining why cannabinoid receptors are present at such high levels in regions controlling and processing motor information. Cannabinoid receptors have been shown to be co-localized with both dopamine D1 and D2 receptor within the striatum. Glutamate is the predominant excitatory transmitter used in the basal ganglia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurotransmission
KW  - cannabinoids
KW  - basal ganglia
KW  - neural receptors
KW  - glutamate
KW  - rats
KW  - 1997
KW  - Basal Ganglia
KW  - Cannabinoids
KW  - Neural Receptors
KW  - Neurotransmission
KW  - Glutamic Acid
KW  - Rats
KW  - 1997
DO  - 10.1111/j.1460-9568.1997.tb01390.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13559-001&site=ehost-live&scope=site
UR  - 
UR  - ORCID: 0000-0002-5997-6898
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13559-005
AN  - 2008-13559-005
AU  - Vogels, Rufin
AU  - Saunders, Richard C.
AU  - Orban, Guy A.
T1  - Effects of inferior temporal lesions on two types of orientation discrimination in the macaque monkey.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1997/02//
VL  - 9
IS  - 2
SP  - 229
EP  - 245
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Vogels, Rufin, Laboratorium voor Neuro-en Psychofysiologie, Faculteit der Geneeskunde, KU Leuven, Campus Gasthuisberg, Herestraat, B-3000, Leuven, Belgium
N1  - Accession Number: 2008-13559-005. PMID: 9058044 Partial author list: First Author & Affiliation: Vogels, Rufin; Laboratorium voor Neuro-en Psychofysiologie, Faculteit der Geneeskunde, KU Leuven, Leuven, Belgium. Other Publishers: Blackwell Publishing. Release Date: 20101115. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Vogels, Rufin. Major Descriptor: Forebrain; Spatial Orientation (Perception); Temporal Lobe. Minor Descriptor: Monkeys; Perceptual Discrimination. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Feb, 1997. Publication History: Accepted Date: Sep 3, 1996; Revised Date: Aug 30, 1996; First Submitted Date: Apr 9, 1996. Copyright Statement: European Neuroscience Association
AB  - Rhesus monkeys with transection of the forebrain commissures were trained in two different tasks in which grating orientation was the discriminandum. In the temporal same—different task, the monkeys had to judge whether or not two successively presented gratings differed in orientation. In the identification task, we measured how well the monkey could judge the orientation of the grating. The performance in any task was affected neither by a unilateral anterior temporal cortical area lesion nor by a subsequent posterior temporal cortical area lesion in the same hemisphere resulting in a two-stage inferior temporal (IT) lesion. However, a single stage IT (combined anterior and posterior temporal cortical areas) lesion of the other hemisphere severely disrupted the performance in the temporal same-different task, but only barely increased just noticeable differences in orientation in the identification task. This indicates that the impairment in a temporal comparison task after an IT lesion is not due to a perceptual coding deficit, but is related to the temporal comparison per se. Thus, IT is involved in the temporal comparison of successively presented stimuli. On the other hand, the two IT lesions, each having a different history (single versus two stage) had dramatically different behavioural effects, suggesting an important role for adult brain plasticity in determining the behavioural outcome of a brain lesion. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - inferior temporal lesions
KW  - orientation discrimination
KW  - monkeys
KW  - temporal lobe
KW  - 1997
KW  - Forebrain
KW  - Spatial Orientation (Perception)
KW  - Temporal Lobe
KW  - Monkeys
KW  - Perceptual Discrimination
KW  - 1997
U1  - Sponsor: FGWO. Grant: 9.0039.90. Recipients: No recipient indicated
U1  - Sponsor: Vision and Memory. Grant: IUAP-22. Recipients: No recipient indicated
U1  - Sponsor: NFWO research associate. Recipients: Vogels, Rufin
DO  - 10.1111/j.1460-9568.1997.tb01394.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13559-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13559-008
AN  - 2008-13559-008
AU  - Nakanishi, Hajime
AU  - Sun, Yun
AU  - Nakamura, Richard K.
AU  - Mori, Kentaro
AU  - Ito, Masanori
AU  - Suda, Sumio
AU  - Namba, Hiroki
AU  - Storch, Fredric I.
AU  - Dang, Thao P.
AU  - Mendelson, Wallace
AU  - Mishkin, Mortimer
AU  - Kennedy, Charles
AU  - Gillin, J. Christian
AU  - Smith, Carolyn Beebe
AU  - Sokoloff, Louis
T1  - Positive correlations between cerebral protein synthesis rates and deep sleep in Macaca mulatta.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1997/02//
VL  - 9
IS  - 2
SP  - 271
EP  - 279
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Smith, Carolyn Beebe, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Building 36, Room 1A-05, 36 Convent Drive, MSC 4030, Bethesda, MD, US, 20892-4030
N1  - Accession Number: 2008-13559-008. PMID: 9058047 Partial author list: First Author & Affiliation: Nakanishi, Hajime; Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20101115. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: International Symposium on Cerebral Blood Flow and Metabolism, 14th, 1989, Bologna, Italy. Conference Note: The results were presented in part at the aforementioned conference and at the and the 25th Annual Meeting of the Society for Neuroscience, San Diego, CA, 1995 (Smith ef al., 1995a). Major Descriptor: Cerebral Cortex; Leucine; Proteins; Rapid Eye Movement. Minor Descriptor: Monkeys. Classification: Physiological Processes (2540). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 1997. Publication History: Accepted Date: Sep 18, 1996; Revised Date: Sep 16, 1996; First Submitted Date: Jun 17, 1996. 
AB  - Local rates of cerebral protein synthesis (ICPSleu), were determined with the autoradiographic L-[1-¹⁴C]leucine method in seven awake and seven asleep, adult rhesus monkeys conditioned to sleep in a restraining chair in a darkened, ventilated chamber while EEG, EOG, and EMG were monitored. Prior to the period of measurement all animals slept for 1–4 h. Controls were awakened after at least one period of rapid-eye-movement (REM) sleep. Experimental animals were allowed to remain asleep, and they exhibited non-REM sleep for 71–99% of the experimental period. Statistically significant differences in ICPSleu between control and experimental animals were found in four of the 57 regions of brain examined, but these effects may have occurred by chance. In the sleeping animals, however, correlations between ICPSleu, and percent time in deep sleep were positive in all regions and were statistically significant (P≤ 0.05) in 35 of the regions. When time in deep sleep was weighted for the integrated specific activity of leucine in grey matter, positive correlations were statistically significant (P≤ 0.05) in 18 regions in the experimental animals. These results suggest that rates of protein synthesis are increased in many regions of the brain during deep sleep compared with light sleep. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cerebral proteins
KW  - deep sleep
KW  - monkeys
KW  - rapid eye movement
KW  - leucine
KW  - 1997
KW  - Cerebral Cortex
KW  - Leucine
KW  - Proteins
KW  - Rapid Eye Movement
KW  - Monkeys
KW  - 1997
DO  - 10.1111/j.1460-9568.1997.tb01397.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13559-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 
TY  - JOUR
ID  - 2015-39785-028
AN  - 2015-39785-028
AU  - Granholm, Ann-Charlotte E.
AU  - Srivastava, Nisha
AU  - Mott, Justin L.
AU  - Henry, Stephanie
AU  - Henry, Michael
AU  - Westphal, Heiner
AU  - Pichel, Jose G.
AU  - Shen, Liya
AU  - Hoffer, Barry J.
T1  - Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): Immunohistochemical studies.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/02//
VL  - 17
IS  - 3
SP  - 1168
EP  - 1178
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Granholm, Ann-Charlotte E., Department of Basic Science, University of Colorado Health Sciences Center, P.O. Box C286, 4200 East 9th Avenue, Denver, CO, US, 80262
N1  - Accession Number: 2015-39785-028. PMID: 8994069 Partial author list: First Author & Affiliation: Granholm, Ann-Charlotte E.; Department of Basic Science, University of Colorado Health Sciences Center, Denver, CO, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Peripheral Nervous System; Neuroglia; Neurotrophic Factor; Immunocytochemistry. Minor Descriptor: Mice; Morphology. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Feb, 1997. Publication History: Accepted Date: Nov 22, 1996; Revised Date: Nov 18, 1996; First Submitted Date: Aug 29, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Glial cell line-derived neurotrophic factor (GDNF) is a member of the TGF-β superfamily of growth factors with neurotrophic activity on midbrain dopaminergic neurons and on developing and mature motoneurons of the brainstem and spinal cord. To investigate the extent of GDNF dependency of central and peripheral nervous structures during development, we have performed an immunohistochemical analysis of sections from the whole head including brain, peripheral ganglia, developing teeth and tongue, as well as intestines, in mutant mice lacking a part of the third exon that encodes the GDNF protein. As described previously, these null-mutated mice lack most of the enteric nerve plexus and are subject to agenesis or severe dysgenesis of the kidneys. In the present communication, we examined the development of vibrissae and incisor and molar teeth, as well as the innervation of these structures, and found no differences between null-mutated and control mice. A decrease in the immunohistochemical labeling intensity with tyrosine hydroxylase was observed in the superior cervical ganglion (SCG), as well as in the pontine nucleus locus coeruleus, and the sympathetic innervation of blood vessels and glands in the head was significantly decreased. None of the brain nuclei studied exhibited any significant decreases in the total number of neurons, but the packing density of neurons in the nucleus locus coeruleus was decreased. These data indicate that GDNF might be one neurotrophic factor that contributes to the development of central and peripheral noradrenergic neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glial cell line-derived neurotrophic factor
KW  - aminergic neurons
KW  - substantia nigra
KW  - locus coeruleus
KW  - gastrointestinal innervation
KW  - tooth development
KW  - basal forebrain
KW  - 1997
KW  - Central Nervous System
KW  - Peripheral Nervous System
KW  - Neuroglia
KW  - Neurotrophic Factor
KW  - Immunocytochemistry
KW  - Mice
KW  - Morphology
KW  - 1997
U1  - Sponsor: National Institutes of Health, US. Grant: MH49661; NSO9199; AG04418; AG12122. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39785-028&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39786-009
AN  - 2015-39786-009
AU  - Pende, Mario
AU  - Fisher, Tracey L.
AU  - Simpson, Peter B.
AU  - Russell, James T.
AU  - Blenis, John
AU  - Gallo, Vittorio
T1  - Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: Role of calcium ions, protein kinase c, and mitogen-activated protein kinase/ribosomal S6 kinase pathway.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/02//
VL  - 17
IS  - 4
SP  - 1291
EP  - 1301
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gallo, Vittorio, Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A78, 49 Convent Drive, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-39786-009. PMID: 9006973 Partial author list: First Author & Affiliation: Pende, Mario; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Nerve Growth Factor; Neurotransmitters; Neuroglia; CREB Activation; Phosphorylation. Minor Descriptor: Calcium Ions; Proteins; Rats; Mitogen Activated Protein Kinase; Progenitor Cells. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Feb, 1997. Publication History: Accepted Date: Dec 4, 1996; Revised Date: Nov 8, 1996; First Submitted Date: Sep 18, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - To understand how extracellular signals may produce long-term effects in neural cells, we have analyzed the mechanism by which neurotransmitters and growth factors induce phosphorylation of the transcription factor cAMP response element binding protein (CREB) in cortical oligodendrocyte progenitor (OP) cells. Activation of glutamate receptor channels by kainate, as well as stimulation of G-protein-coupled cholinergic receptors by carbachol and tyrosine kinase receptors by basic fibroblast growth factor (bFGF), rapidly leads to mitogen-activated protein kinase (MAPK) phosphorylation and ribosomal S6 kinase (RSK) activation. Kainate and carbachol activation of the MAPK pathway requires extracellular calcium influx and is accompanied by protein kinase C (PKC) induction, with no significant increase in GTP binding to Ras. Conversely, growth factor-stimulated MAPK phosphorylation is independent of extracellular calcium and is accompanied by Ras activation. Both basal and stimulated MAPK activity in OP cells are influenced by cytoplasmic calcium levels, as shown by their sensitivity to the calcium chelator bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid. The kinetics of CREB phosphorylation in response to the various agonists corresponds to that of MAPK activation. Moreover, CREB phosphorylation and MAPK activation are similarly affected by calcium ions. The MEK inhibitor PD 098059, which selectively prevents activation of the MAPK pathway, strongly reduces induction of CREB phosphorylation by kainate, carbachol, bFGF, and the phorbol ester TPA. We propose that in OPs the MAPK/RSK pathway mediates CREB phosphorylation in response to calcium influx, PKC activation, and growth factor stimulation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - non-NMDA receptors
KW  - muscarinic receptors
KW  - basic fibroblast growth factor
KW  - ribosomal S6 kinase
KW  - transcription factor
KW  - oligodendrocytes
KW  - 1997
KW  - Nerve Growth Factor
KW  - Neurotransmitters
KW  - Neuroglia
KW  - CREB Activation
KW  - Phosphorylation
KW  - Calcium Ions
KW  - Proteins
KW  - Rats
KW  - Mitogen Activated Protein Kinase
KW  - Progenitor Cells
KW  - 1997
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39786-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107190303
T1  - Randomized trials of sodium reduction: an overview...Conference on dietary sodium and health. Proceedings of a symposium held in Arlington, VA, December 15-16, 1994
AU  - Cutler JA
AU  - Follmann D
AU  - Allender PS
Y1  - 1997/02/02/Feb97 Supplement
N1  - Accession Number: 107190303. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Supplement Title: Feb97 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Diet, Sodium-Restricted
KW  - Hypertension -- Diet Therapy
KW  - Blood Pressure
KW  - Dose-Response Relationship, Drug
KW  - Linear Regression
KW  - Meta Analysis
SP  - 643S
EP  - 51S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 65
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - We updated a previously published overview of randomized clinical trials testing the effects of reducing sodium intake. We excluded trials that had confounded designs, enrolled preadolescent study populations, tested intakes outside the usual range for the US population, or reported neither systolic nor diastolic blood pressure. Thirty-two trials with outcome data for 2635 subjects were included. Two reviewers abstracted information independently and differences were reconciled. Pooled blood pressure differences between treated and control groups were highly significant for all trials combined and for trials in hypertensive and normotensive subjects pooled separately. The effects on blood pressure of lowering sodium in hypertensive and normotensive subjects, respectively (each trial weighted according to sample size), were -4.8/-2.5 and -1.9/-1.1 mm Hg (systolic/diastolic). Median differences in sodium excretion between sodium-reduction and control groups in these subgroups were -77 and -76 mmol/24 h, respectively. Weighted linear-regression analyses across the trials showed dose responses, which were more consistent for trials in normotensive subjects. These associations were, per 100 mmol Na/24 h, -5.8/-2.5 and -2.3/-1.4 mm Hg in hypertensive and normotensive subjects, respectively. There is no evidence that sodium reduction as achieved in these trials presents any safety hazards. The blood pressure reduction that would result from a substantial lowering of dietary sodium in the US population could reduce cardiovascular morbidity and mortality. Copyright (c) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 9022560.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107190303&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105823332
T1  - Birth cohort and calendar period trends in breast cancer mortality in the United States and Canada.
AU  - Tarone RE
AU  - Chu KC
AU  - Gaudette LA
Y1  - 1997/02/05/
N1  - Accession Number: 105823332. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Blacks -- Statistics and Numerical Data
KW  - Breast Neoplasms -- Ethnology
KW  - Breast Neoplasms -- Mortality
KW  - Whites -- Statistics and Numerical Data
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Canada
KW  - Demography
KW  - Female
KW  - Fertility
KW  - Middle Age
KW  - Mortality -- Trends
KW  - Prospective Studies
KW  - United States
KW  - Human
SP  - 251
EP  - 256
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 3
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 9017006.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105823332&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
T1  - Hypertrophic Cardiomyopathy: Evaluation and Treatment of Patients at High Risk for Sudden Death.
AU  - Fananapazir, Lameh
AU  - McAreavey, Dorothea
JO  - Pacing & Clinical Electrophysiology
JF  - Pacing & Clinical Electrophysiology
Y1  - 1997/02/15/
VL  - 20
IS  - 2P2
SP  - 478
EP  - 501
SN  - 01478389
N1  - Accession Number: 17424251; Author: Fananapazir, Lameh: 1 email: fananapA@gwgate.nhlbi.nih.gov. Author: McAreavey, Dorothea: 1 ; Author Affiliation: 1 Cardiology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.; No. of Pages: 24; Language: English; Publication Type: Article; Update Code: 20050628
N2  - Hypertrophic cardiomyopathy (HCM) is a heritable disease characterized by LV hypertrophy with markedly variable clinical, morphological, and genetic manifestations. It is the most common cause of sudden death in otherwise healthy voting individuals. HCM patients often have disabling symptoms and are prone to arrhythmias. Frequently, there is associated LV systolic and diastolic dysfunction, LV outflow obstruction, and myocardial ischemia. Over the past decade, progress has been made in identifying patients who are at high risk for sudden death, in elucidating potential mechanisms of sudden death, and in defining therapeutic algorithms that may improve prognosis. It has also been possible to determine the genetic defect in some of the patients and to correlate clinical findings with the molecular defects. An exciting development has been the use of the dual chamber pacemaker as an alternative to cardiac surgery to improve symptoms and relieve LV outflow obstruction. ABSTRACT FROM AUTHOR
KW  - *CARDIOMYOPATHIES
KW  - *HYPERTROPHIC cardiomyopathy
KW  - *HEART diseases
KW  - *HEART
KW  - *HEART beat
KW  - *ISCHEMIA
KW  - SIZE
KW  - hypertrophic cardiomyopathy
KW  - sudden death
KW  - systolic and diastolic dysfunction
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DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 105823346
T1  - In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen.
AU  - Correale P
AU  - Walmsley K
AU  - Nieroda C
AU  - Zaremba S
AU  - Zhu M
AU  - Schlom J
AU  - Tsang KY
Y1  - 1997/02/19/
N1  - Accession Number: 105823346. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Colorectal Neoplasms -- Immunology
KW  - Leukemia, Myeloid, Chronic -- Immunology
KW  - Prostate-Specific Antigen -- Immunology
KW  - Prostatic Neoplasms -- Immunology
KW  - Proteins -- Immunology
KW  - T Lymphocytes
KW  - Antigens -- Immunology
KW  - Cells
KW  - Documentation
KW  - Flow Cytometry
KW  - HLA Antigens -- Metabolism
KW  - Male
KW  - Prostate-Specific Antigen -- Metabolism
KW  - Viruses
SP  - 293
EP  - 300
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 4
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA.
U2  - PMID: 9048833.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105823346&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107254686
T1  - Alcohol and the cardiovascular system: molecular mechanisms for beneficial and harmful action.
AU  - Zakhari S
Y1  - 1997/03//
N1  - Accession Number: 107254686. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; glossary; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0365245. 
KW  - Alcohols -- Therapeutic Use
KW  - Coronary Disease -- Prevention and Control
KW  - Cardiovascular Diseases -- Etiology
KW  - Alcoholism -- Complications
KW  - Lipoproteins -- Physiology
KW  - Lipoproteins -- Metabolism
SP  - 21
EP  - 96
JO  - Alcohol Health & Research World
JF  - Alcohol Health & Research World
JA  - ALCOHOL HEALTH RES WORLD
VL  - 21
IS  - 1
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - Alcohol can be beneficial or harmful to the cardiovascular system, depending on the amount consumed and the characteristics of the consumer. Of the numerous cellular and molecular mechanisms that are thought to explain the beneficial effects of moderate drinking, this article discusses four, involving (1) high density lipoproteins, (2) cellular signaling, (3) platelet function in blood clot formation, and (4) stimulation of blood clot dissolution. Although light-to-moderate drinking can protect against coronary artery disease, heavy alcohol consumption can damage the cardiovascular system, resulting in maladies such as heart muscle disorders, irregular heart rhythms, high blood pressure, and strokes. This article summarizes representative epidemiological and animal studies on these cardiovascular consequences of chronic heavy alcohol consumption and reviews mechanisms that have been suggested to explain alcohol's effects.
SN  - 0090-838X
AD  - Biomedical Research Branch, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107277652
T1  - Characteristics of older pedestrians who have difficulty crossing the street.
AU  - Langlois JA
AU  - Keyl PM
AU  - Guralnik JM
AU  - Foley DJ
AU  - Marottoli RA
AU  - Wallace RB
Y1  - 1997/03//
N1  - Accession Number: 107277652. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: Short Portable Mental Status Questionnaire (SPMSQ) (Pfeiffer). Grant Information: Supported in part by contracts NO1-AG-0-2105 and NO1-AG-0-2106 from the National Institute on Aging and the US Department of Transportation. NLM UID: 1254074. 
KW  - Walking -- In Old Age
KW  - Safety -- In Old Age
KW  - Community Living -- In Old Age
KW  - Functional Status -- In Old Age
KW  - Interview Guides
KW  - Descriptive Research
KW  - Epidemiological Research
KW  - Stratified Random Sample
KW  - Interviews
KW  - Telephone
KW  - Self Report
KW  - Data Analysis Software
KW  - Descriptive Statistics
KW  - T-Tests
KW  - Urban Areas
KW  - Functional Assessment
KW  - Chi Square Test
KW  - Multiple Logistic Regression
KW  - Chronic Disease -- Complications
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 393
EP  - 397
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 87
IS  - 3
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study examined the sociodemographic and health characteristics and problems of older pedestrians. METHODS: Interviews and assessments were conducted with 1249 enrollees aged 72 or older from the New Haven, Conn, community of the Established Populations for Epidemiologic Studies of the Elderly who agreed to participate in a seventh follow-up. RESULTS: Approximately 11% of the New Haven residents reported difficulty crossing the street. Older pedestrians needing help in one or more activities of daily living were more than 10 times as likely as others, and those with the slowest walking speeds were nearly 3 times as likely as others, to report difficulty crossing the street. Fewer than 1% of these pedestrians aged 72 or older had a normal walking speed sufficient to cross the street in the time typically allotted at signalized intersections (1.22 m/sec). CONCLUSIONS: Crossing times at signalized intersections in areas with large populations of elders should be extended, and the recommended walking speed for timing signalized crossings should be modified to reflect the range of abilities among older pedestrians.
SN  - 0090-0036
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Gateway Bldg., Suite 3C-309, 7201 Wisconsin Ave, Bethesda, MD 30892-9205
U2  - PMID: 9096539.
DO  - 10.2105/AJPH.87.3.393
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107181531
T1  - Apoptosis.
AU  - Fleisher TA
Y1  - 1997/03//1997 Mar
N1  - Accession Number: 107181531. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9503580. 
KW  - Cell Death
KW  - Education, Continuing (Credit)
SP  - 245
EP  - 50 1p
JO  - Annals of Allergy, Asthma & Immunology
JF  - Annals of Allergy, Asthma & Immunology
JA  - ANN ALLERGY ASTHMA IMMUNOL
VL  - 78
IS  - 3
CY  - New York, New York
PB  - Elsevier Science
AB  - LEARNING OBJECTIVES: Reading this article will introduce the reader to the basic concept of physiologic cell death referred to as apoptosis. In addition, the role of apoptosis in immune function as well as its contribution to various clinical disorders will be developed. DATA SOURCE: The author's experience with recently described patients who have a unique autoimmune syndrome associated with a defect in apoptosis. In addition, recent reviews on the subject of apoptosis in health and disease served as informational outlines. STUDY SELECTION: Data source included pertinent reviews and articles meeting the educational objectives and these were critically reviewed. RESULTS: Apoptosis is a critical process in cellular homeostasis that only recently has been appreciated. Its role in both immune development and the control of immune responses as well as in T cell cytotoxic effector function has been established. Information is accumulating that diseases such as cancer can be linked to underlying defects in the apoptosis pathway allowing cells that normally would have been eliminated to live. The role of alterations in apoptosis in other chronic diseases, including autoimmune and neurodegenerative disorders, is beginning to emerge. CONCLUSIONS: Apoptosis plays a central part in normal tissue homeostasis as well as having a role in a variety of clinical diseases that are characterized by either increased or decreased cell survival.
SN  - 1081-1206
AD  - Chief, Immunology Service, CP; Warren G. Magnuson Clinical Center; National Institutes of Health; Bethesda, MD
U2  - PMID: 9087147.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107181531&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
AU  - Sternberg, Kathleen J.
AU  - Esplin, Phillip W.
AU  - Hershkowitz, Irit
AU  - Orbach, Yael
AU  - Hovav, Meir
T1  - CRITERION-BASED CONTENT ANALYSIS: A FIELD VALIDATION STUDY.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1997/03//
VL  - 21
IS  - 3
M3  - Article
SP  - 225
EP  - 264
SN  - 01452134
AB  - Transcripts of forensic interviews with 98 alleged victims of child sexual abuse were scored for the presence or absence of certain criteria believed to be more characteristic of accounts concerning experienced than nonexperienced events. Other information regarding the events was independently evaluated by individuals unfamiliar with the children's accounts. As predicted, more of the CBCA criteria were present in accounts independently rated as Likely or Very Likely to have occurred (M = 6.74) than in accounts of events deemed Unlikely or Very Unlikely to have occurred (M = 4.85). In addition, several of the criteria were helpful in distinguishing between plausible and implausible accounts. The group differences were not as dramatic as those reported in earlier studies, however, and the results suggest caution regarding forensic application of the CBCA system. (English) [ABSTRACT FROM AUTHOR]
AB  - En esta investigación se realizaron evaluaciones de las transcripciones de entrevistas forenses realizadas a 98 presuntas víctimas de abuso sexual infantil. Se trataba de valorar la presencia o ausencia de ciertos criterios considerados como más característicos de los relatos de acontecimientos que han ocurrido que de los que no han ocurrido. Otro tipo de información relacionada con los acontecimientos fue independientemente evaluada por individuos no familiarizados con los relatos de los niños. Tal y como se había predicho, en los relatos que hablan sido puntuados independientemente como "Probable" o "Muy Probable" que hubieran ocurrido (M = 6.74) estuvieron presentes un mayor número de los criterios CBCA (Criterios basados en el Análisis de Contenido) que en los relatos de acontecimientos considerados como "Improbable" o "Muy Improbable" que hubieran ocurrido (M = 4.85). Además, varios de los criterios fueron útiles para distinguir entre relatos verosímiles o inverosímiles. Sin embargo, las diferencias de grupo no fueron tan marcadas como las señaladas estudios previos y los resultados sugieren tener precaución en la aplicación forense del sistema CBCA. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Les transciptions d'entrevues forensiques de 98 enfants présumés victimes d'agressions sexuelles ont été évaluées pour déterminer la présence ou l'absence de certains critéres qu'on retrouve plus habituellement dans des récits d'expériences vécues que dans des récits du non vécu. D'autres renseignements concernant ces événements ont été évalués indépendamment par des individus qui n'étaient pas au courant des récits des enfants. Tel que prévu, on a retrouvé un plus grand nombre de critères lorsque les récits avaient reçu indépendamment une cote probable et fort probable (M = 6.74) que dans les récits cotés peu probable et trés peu probable (M = 4.85). De plus, bon nombre de critères étaient utiles pour distinguer entre le plausible et le non plausible. Toutefois, les différences entre les groupes n'étaient pas aussi dramatiques que l'ont rapporté des études antérieures. Les résultats suggèrent de prendre garde lorsqu'il s'agit de mettre en application le processus dit de l'analyse selon des critères, dans un contexte forensique. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERVIEWING in child abuse
KW  - CHILD sexual abuse
KW  - EVALUATION
KW  - CHILD abuse
KW  - SEX crimes
KW  - CBCA ratings
KW  - Child witnesses
KW  - Credibility
KW  - Sexual abuse
N1  - Accession Number: 9709060814; Lamb, Michael E. 1 Sternberg, Kathleen J. 1 Esplin, Phillip W. Hershkowitz, Irit 2 Orbach, Yael 2 Hovav, Meir 3; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, MD, USA  2: National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA  3: Division of Correctional Services and Services for Youth in Distress, Ministry of Labor and Social Welfare, Jerusalem, Israel; Source Info: Mar1997, Vol. 21 Issue 3, p225; Subject Term: INTERVIEWING in child abuse; Subject Term: CHILD sexual abuse; Subject Term: EVALUATION; Subject Term: CHILD abuse; Subject Term: SEX crimes; Author-Supplied Keyword: CBCA ratings; Author-Supplied Keyword: Child witnesses; Author-Supplied Keyword: Credibility; Author-Supplied Keyword: Sexual abuse; Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dell'Angelica, Esteban C.
AU  - Ohno, Hiroshi
AU  - Ooi, Chean Eng
AU  - Rabinovich, Efrat
AU  - Roche, Katherine W.
AU  - Bonifacino, Juan S.
T1  - AP-3: an adaptor-like protein complex with ubiquitous expression.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/03//3/1/97
VL  - 16
IS  - 5
M3  - Article
SP  - 917
EP  - 928
SN  - 02614189
AB  - We have identified two closely related human proteins (σ3A and σ3B) that are homologous to the small chains, σ1 and σ2, of clathrin-associated adaptor complexes. Northern and Western blot analyses demonstrate that the products of both the σ3A and σ3B genes are expressed in a wide variety of tissues and cell lines. σ3A and σ3B are components of a large complex, named AP-3, that also contains proteins of apparent molecular masses of 47, 140 and 160 kDa. In non-neuronal cells, the 47 kDa protein most likely corresponds to the medium chain homolog p47A, and the 140 kDa protein is a homolog of the neuron-specific protein β-NAP. Like other members of the medium-chain family, the p47A chain is capable of interacting with the tyrosine-based sorting signal YQRL from TGN38. Immunofluorescence microscopy analyses show that the σ3-containing complex is present both in the area of the TGN and in peripheral structures, some of which contain the transferrin receptor. These results suggest that the σ3 chains are components of a novel, ubiquitous adaptor-like complex involved in the recognition of tyrosine-based sorting signals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - PROTEINS -- Analysis
KW  - TRANSFERRIN
KW  - GENES
KW  - NEURONS
KW  - CELLS
KW  - CELL receptors
KW  - HOMOLOGY (Biology)
KW  - adaptors
KW  - coats
KW  - endosomes
KW  - sorting signals
N1  - Accession Number: 13005357; Dell'Angelica, Esteban C. 1 Ohno, Hiroshi 1 Ooi, Chean Eng 1 Rabinovich, Efrat 1 Roche, Katherine W. 1 Bonifacino, Juan S. 1; Affiliation:  1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, MD, USA]; Source Info: 3/1/97, Vol. 16 Issue 5, p917; Subject Term: PROTEINS; Subject Term: PROTEINS -- Analysis; Subject Term: TRANSFERRIN; Subject Term: GENES; Subject Term: NEURONS; Subject Term: CELLS; Subject Term: CELL receptors; Subject Term: HOMOLOGY (Biology); Author-Supplied Keyword: adaptors; Author-Supplied Keyword: coats; Author-Supplied Keyword: endosomes; Author-Supplied Keyword: sorting signals; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/16.5.917
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sable, Marjorie R.
AU  - Spencer, John C.
AU  - Stockbauer, Joseph W.
AU  - Schramm, Wayne F.
AU  - Howell, Vicky
AU  - Herman, Allen A.
T1  - Pregnancy Wantedness and Adverse Pregnancy Outcomes: Differences by Race and Medicaid Status.
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
Y1  - 1997/03//Mar/Apr97
VL  - 29
IS  - 2
M3  - Article
SP  - 76
EP  - 81
PB  - Guttmacher Institute, Inc.
SN  - 00147354
AB  - The relationship between pregnancy wantedness and adverse pregnancy outcomes was studied using data from 2,828 mothers who participated in the Missouri Maternal and Infant Health Survey. The wantedness of a pregnancy was measured using traditional classifications of mis-timed and unwanted, as well as additional measures gauging how the woman felt about the pregnancy while she was pregnant Fifty-eight percent of the very low birth weight infants and 59% of the moderately low birth weight infants resulted from unintended pregnancies, as did 62% of the normal-birth-weight infants. Logistic regression showed that mothers of very low birth weight infants were significantly more likely than those who had a normal-weight baby to report that they had fell unhappy about the pregnancy (odds ratio of 1.53). Very low birth weight was also associated with early denial of the pregnancy (1.54). Odds ratios associating these two unwantedness categories with low-birth-weight babies were higher among Medicaid recipients than among women not receiving Medicaid. Associations between very low birth weight and the denial variable were also significant among white women when very low birth weight outcomes were compared with normal outcomes, but there was no significant association among black women. There were no significant associations between low birth weight and the traditional unwantedness variables. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Family Planning Perspectives is the property of Guttmacher Institute, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANCY
KW  - HEALTH surveys
KW  - NEWBORN infants
KW  - BIRTH weight
KW  - BLACK women
KW  - LOGISTIC regression analysis
N1  - Accession Number: 9704201578; Sable, Marjorie R. 1 Spencer, John C. 2 Stockbauer, Joseph W. 3 Schramm, Wayne F. 3 Howell, Vicky 4 Herman, Allen A. 5; Affiliation:  1: Assistant professor at the School of Social Work at the University of Missouri-Columbia, Columbia, Mo  2: Senior research analyst, Assessment Resource Center, College of Education at the University of Missouri-Columbia, Columbia, Mo  3: Research analysts with the Center for Health Information, Management and Epidemiology at the Missouri Department of Health, Jefferson City, Mo  4: Chief, Bureau of Health Data Analysis at the Missouri Department of Health, Jefferson City, Mo  5: Visiting scientist at the National Institute of Child Health and Human Development (NICHD), Bethesda, Md; Source Info: Mar/Apr97, Vol. 29 Issue 2, p76; Subject Term: PREGNANCY; Subject Term: HEALTH surveys; Subject Term: NEWBORN infants; Subject Term: BIRTH weight; Subject Term: BLACK women; Subject Term: LOGISTIC regression analysis; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 6577
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 106992869
T1  - An ethics framework for assisting clinician-managers in resource allocation decision making.
AU  - Meslin EM
AU  - Lemieux-Charles L
AU  - Wortley JT
Y1  - 1997///Spring97
N1  - Accession Number: 106992869. Language: English. Entry Date: 20010126. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. Grant Information: Ontario Ministry of Health's Hospital Incentive Fund. NLM UID: 7611540. 
KW  - Resource Allocation -- Canada
KW  - Ethics
KW  - Canada
KW  - Ontario
KW  - Surveys
KW  - Conceptual Framework
KW  - Physicians
KW  - Nurses
KW  - Management
KW  - Focus Groups
KW  - Questionnaires
KW  - Random Sample
KW  - National Health Programs -- Economics -- Canada
KW  - Sex Factors
KW  - Decision Making
KW  - Morals
KW  - Philosophy
KW  - Multidisciplinary Care Team
KW  - Financing, Government
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 33
EP  - 48
JO  - Hospital & Health Services Administration
JF  - Hospital & Health Services Administration
JA  - HOSP HEALTH SERV ADM
VL  - 42
IS  - 1
CY  - Chicago, Illinois
PB  - Health Administration Press
AB  - In response to continued pressure on the Canadian healthcare system, hospitals are implementing structural changes to address issues of cost containment, utilization, and resource allocation. One strategy has been to decentralize managerial decision making to clinicians, creating 'clinician-managers' (CMs). We surveyed 3,000 hospital-based CMs in Ontario, Canada (including physicians, nurses, and other health professionals), in order to understand the nature and frequency of the ethical issues they face as a consequence of their involvement in resource allocation decisions, and to identify mechanisms for dealing with these problems in their hospitals. Based on the survey results, we developed a Management Ethics Framework to assist CMs to reach an ethically justifiable resolution of these types of problems, both individually, and in the context of their membership in the healthcare team. The results, and particularly the discussion that follows, represent a confluence of philosophical, clinical, and organizational perspectives on ethics and resource allocation by clinicians.
SN  - 8750-3735
AD  - Director, ELSI Research Program, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 10164897.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107234642
T1  - Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection.
AU  - Gomez R
AU  - Romero R
AU  - Edwin SS
AU  - David C
Y1  - 1997/03//1997 Mar
N1  - Accession Number: 107234642. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Amnion -- Microbiology
KW  - Bacterial Infections -- Complications
KW  - Fetal Membranes, Premature Rupture -- Etiology
KW  - Labor, Premature -- Etiology
KW  - Infant, Newborn
KW  - Pregnancy
KW  - Female
SP  - 135
EP  - 176
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 11
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
SN  - 0891-5520
AD  - Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland
U2  - PMID: 9067790.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Pequegnat, Willo
AU  - Bray, James H.
T1  - Families and HIV/AIDS: Introduction to the special section.
JO  - Journal of Family Psychology
JF  - Journal of Family Psychology
Y1  - 1997/03//
VL  - 11
IS  - 1
M3  - Article
SP  - 3
EP  - 10
SN  - 08933200
AB  - This article provides an introduction and overview of the role of families in preventing and adapting to HIV/AIDS. The unique definition of family in the context of HIV/ AIDS is discussed as well as the importance of considering the family as a context for research in this area. Families can be important in deterring the spread of the disease because of their pivotal role in education and training about sexual behavior and health promotion. Families also serve a critical role in helping their HIV-infected members cope with disease. A taxonomy of the problems faced by families is presented. The role of the National Institute of Mental Health's Initiative on Family and HIV/AIDS in supporting and stimulating current and future research is discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FAMILIES
KW  - AIDS (Disease)
KW  - ADJUSTMENT (Psychology)
KW  - HUMAN sexuality
KW  - HEALTH promotion
KW  - HEALTH education
N1  - Accession Number: 9711223230; Pequegnat, Willo 1; Email Address: wpequegn@nih.gov Bray, James H. 2; Affiliation:  1: National Institute of Mental Health  2: Baylor College of Medicine; Source Info: Mar97, Vol. 11 Issue 1, p3; Subject Term: FAMILIES; Subject Term: AIDS (Disease); Subject Term: ADJUSTMENT (Psychology); Subject Term: HUMAN sexuality; Subject Term: HEALTH promotion; Subject Term: HEALTH education; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Heishman, Stephen J.
AU  - Kozlowski, Lynn T.
AU  - Henningfield, Jack E.
T1  - Nicotine Addiction: Implications for Public Health Policy.
JO  - Journal of Social Issues
JF  - Journal of Social Issues
Y1  - 1997///Spring97
VL  - 53
IS  - 1
M3  - Article
SP  - 13
EP  - 33
SN  - 00224537
AB  - Although the morbidity and mortality caused by cigarette smoking occur in adult- hood, the initiation of tobacco use and the development of nicotine addiction typically occur during adolescence. The purpose of this paper is to examine the determinants of nicotine addiction, focusing on the development of addiction in youth, and to explore implications for public health policy. An understanding of the pharmacological and nonpharmacological factors that determine the course of nicotine addiction is critical in developing rational policies regarding tobacco products. The Food and Drug Administration `s rule to regulate cigarettes and smokeless tobacco products is discussed. The fact that smokers typically make the transition from casual use to nicotine addiction during adolescence argues for developing and implementing effective prevention efforts and smoking cessation treatment programs that are youth-oriented. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Social Issues is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOBACCO -- Physiological effect
KW  - NICOTINE
KW  - TOBACCO use
KW  - PUBLIC health
KW  - UNITED States
KW  - UNITED States. Food & Drug Administration
N1  - Accession Number: 9710302054; Heishman, Stephen J. 1 Kozlowski, Lynn T. 2 Henningfield, Jack E. 3; Affiliation:  1: National Institute on Drug Abuse, Baltimore, Maryland.  2: Pennsylvania State University.  3: Johns Hopkins University, Baltimore, Maryland.; Source Info: Spring97, Vol. 53 Issue 1, p13; Subject Term: TOBACCO -- Physiological effect; Subject Term: NICOTINE; Subject Term: TOBACCO use; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 21p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Legler, Julie M.
AU  - Ryan, Louise M.
T1  - Latent Variable Models for Teratogenesis Using Multiple Binary Outcomes.
JO  - Journal of the American Statistical Association
JF  - Journal of the American Statistical Association
Y1  - 1997/03//
VL  - 92
IS  - 437
M3  - Article
SP  - 13
EP  - 20
SN  - 01621459
AB  - Multiple outcomes are commonly measured in the study of birth defects. The reason is that most teratogens do not cause a single, uniquely defined defect, but rather result in a range of effects, including major malformations, minor anomalies, and deficiencies in birth weight, length and head circumference. The spectrum of effects associated with a particular teratogen is sometimes described as a "syndrome." In this article we develop a latent variable model to characterize exposure effects on multiple binary outcomes. Not only does the method allow comparisons of control and exposed infants with respect to multiple outcomes, but it also provides a measure of the "severity" of each child's condition. Data from a study of the teratogenic effects of anticonvulsants illustrate our results. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LATENT variables
KW  - HUMAN abnormalities
KW  - TERATOGENIC agents
KW  - ANTICONVULSANTS
KW  - BIRTH weight
KW  - Item response theory
KW  - Random effects
KW  - Teratology
N1  - Accession Number: 9703193350; Legler, Julie M. 1; Ryan, Louise M. 2; Affiliations: 1: Mathematical Statistician, National Institutes of Health, Bethesda, MD 20952; 2: Professor, Department of Biostatistics, Harvard School of Public Health and Dana Farber Cancer Institute, Boston, MA 02115; Issue Info: Mar1997, Vol. 92 Issue 437, p13; Subject Term: LATENT variables; Subject Term: HUMAN abnormalities; Subject Term: TERATOGENIC agents; Subject Term: ANTICONVULSANTS; Subject Term: BIRTH weight; Author-Supplied Keyword: Item response theory; Author-Supplied Keyword: Random effects; Author-Supplied Keyword: Teratology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 6017
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107329197
T1  - Incorporating environmental sciences and nursing research: an NINR initiative.
AU  - Grady PA
AU  - Harden JT
AU  - Moritz P
AU  - Amende LM
Y1  - 1997/03//1997 Mar-Apr
N1  - Accession Number: 107329197. Language: English. Entry Date: 19970701. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0401075. 
KW  - Environmental Health
KW  - Research, Nursing
KW  - Nursing Organizations
KW  - Committees
KW  - Research Priorities
KW  - Nurse Researchers
KW  - Interprofessional Relations
SP  - 73
EP  - 75
JO  - Nursing Outlook
JF  - Nursing Outlook
JA  - NURS OUTLOOK
VL  - 45
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - A Working Group convened by the National Institute of Nursing Research to identify environmental health science research gaps, opportunities, and challenges discusses target populations, target areas for clinical studies, research infrastructure needs, and promising areas for nursing research.
SN  - 0029-6554
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, Md
U2  - PMID: 9127346.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107350674
T1  - Everyday practice is the basis of research.
AU  - Robertson SC
AU  - Colborn AP
Y1  - 1997/03//1997 Mar
N1  - Accession Number: 107350674. Language: English. Entry Date: 19971201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 9602488. 
KW  - Occupational Therapy
KW  - Research, Occupational Therapy
KW  - Research Methodology
KW  - Study Design
KW  - Research Question
KW  - Proposal Writing
KW  - Data Collection
KW  - Data Management
KW  - Data Analysis
KW  - Professional Development
SP  - 30
EP  - 35
JO  - OT Practice
JF  - OT Practice
JA  - OT PRACT
VL  - 2
IS  - 3
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
AB  - Susan C. Robertson and Anne Pas Colborn remind practitioners of the importance of clinical research and illustrate how to incorporate it into your practice.
SN  - 1084-4902
AD  - Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107324083
T1  - Postsurgical hindfoot deformity of a patient with rheumatoid arthritis treated with custom-made foot orthoses and shoe modifications.
AU  - Shrader JA
AU  - Siegel KL
Y1  - 1997/03//
N1  - Accession Number: 107324083. Language: English. Entry Date: 19970601. Revision Date: 20150820. Publication Type: Journal Article; case study; pictorial; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0022623. 
KW  - Foot Deformities, Acquired -- Rehabilitation
KW  - Arthritis, Rheumatoid -- Physiopathology
KW  - Orthoses
KW  - Postoperative Complications -- Rehabilitation
KW  - Physical Therapy
KW  - Arthritis, Rheumatoid -- Surgery
KW  - Gait
KW  - Orthopedic Footwear
KW  - Foot Deformities, Acquired -- Etiology
KW  - Aged
KW  - Female
SP  - 296
EP  - 305
JO  - Physical Therapy
JF  - Physical Therapy
JA  - PHYS THER
VL  - 77
IS  - 3
CY  - Alexandria, Virginia
PB  - American Physical Therapy Association
AB  - This case report describes the treatment of a 73-year-old woman with long-standing, severe rheumatoid arthritis, using custom-made foot orthoses and shoe modifications. The patient was referred for physical therapy 4 weeks after triple arthrodesis of her right foot. Her primary complaint was periodic unsteadiness during gait, which necessitated the use of a cane at all times. Other problems included a lower-extremity length discrepancy and right foot pain. Physical therapy included fabrication of bilateral semirigid foot orthoses, shoe modifications, gait training, and instruction in strengthening exercises. After treatment, the patient reported feeling steady during walking without a cane, and she was able to resume community activities without right foot pain. Computerized movement analysis of gait revealed that the use of orthoses and modified footwear reduced weight bearing and movement-pattern abnormalities, as compared with barefoot walking. The findings in this case show that physical therapy including foot orthoses, shoe modifications, gait training, and strengthening exercises can be instrumental in the postsurgical rehabilitation of a patient with severe rheumatoid arthritis.
SN  - 0031-9023
AD  - Rehabilitation Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Room 6s235, 9000 Wisconsin Ave, Bethesda, MD 20892-1604 (joseph_shrader@nih.gov)
U2  - PMID: 9062571.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107173678
T1  - Americans' knowledge of cancer risk and survival.
AU  - Breslow RA
AU  - Sorkin JD
AU  - Frey CM
AU  - Kessler LG
Y1  - 1997/03//1997 Mar-Apr
N1  - Accession Number: 107173678. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0322116. 
KW  - Health Knowledge
KW  - Neoplasms
KW  - Cross Sectional Studies
KW  - Probability Sample
KW  - Interviews
KW  - Descriptive Statistics
KW  - Data Analysis Software
KW  - Health Knowledge -- Evaluation
KW  - Risk Factors
KW  - Neoplasms -- Prognosis
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 170
EP  - 177
JO  - Preventive Medicine
JF  - Preventive Medicine
JA  - PREV MED
VL  - 26
IS  - 2
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
AB  - BACKGROUND: There are more than 500,000 deaths from cancer each year in the United States. This study examines Americans' knowledge of risk factors for breast, cervical, colon, and prostate cancers, which account for over 130,000 of these deaths, and their knowledge of the prospects of surviving these cancers following early detection. METHODS: Data were obtained from 12,035 subjects who completed the 1992 National Health Interview Survey Cancer Control Supplement which includes questions about cancer risk factors and survival. RESULTS: The majority of respondents were unable to identify major cancer risk factors when prompted with a list. Approximately two-thirds did not recognize that age increased the risk for breast and colon cancer, that diet increased the risk for colon cancer, or that multiple sex partners increased the risk for cervical cancer. Knowledge about survival was also poor. Only about half thought they had a good chance of survival following early detection of colon and cervical cancers, for which 5-year relative survival exceeds 90%. CONCLUSIONS: Americans lack knowledge about major risk factors for common cancers and about the prospects of survival following early detection. Knowledge about risk factors and about survival from cervical and colon cancers was poor at all ages, among all races, at all income levels, and at all educational levels. It was poorest among blacks and Hispanics and among those with the lowest income and least education. Americans need education about cancer risk factors and survival.
SN  - 0091-7435
AD  - Applied Research Branch, National Cancer Institute, CPN-313, Bethesda, MD 20892
U2  - PMID: 9085385.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Dancey, J.
AU  - Zee, B.
AU  - Osoba, D.
AU  - Whitehead, M.
AU  - Lu, F.
AU  - Kaizer, L.
AU  - Latreille, J.
AU  - Pater, J. L.
T1  - Quality of life scores: An independent prognostic variable in a general population of cancer patients receiving chemotherapy.
JO  - Quality of Life Research
JF  - Quality of Life Research
Y1  - 1997/03//
VL  - 6
IS  - 2
M3  - Article
SP  - 0
EP  - 0
PB  - Springer Science & Business Media B.V.
SN  - 09629343
AB  - This report examines the prognostic associations between QOL scores measured by the EORTC QLQ-C30 and survival in a large heterogeneous population of cancer patients. Eight hundred and fifty-one cancer patients who were to receive chemotherapy were enrolled in two National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) antiemetic trials. All patients completed the EORTC QLQ-C30 immediately prior to their first chemotherapy. Survival data were available and obtained for 474 of 639 patients (74%). Cox‘s proportional hazards model was used to assess the independent impact of QOL and demographic variables on survival. Presence of metastatic disease, diagnosis of lung or ovarian cancer, ECOG performance status, global quality of life and emotional functioning were significantly associated with survival. Global QOL was predictive in all patients, in subgroups of patients with metastatic disease, with breast and lung cancer and other tumour types. In patients with low global quality of life scores, patients with low emotional functioning ratings lived longer than did patients with high emotional functioning ratings. Patients with high global QOL live significantly longer than do patients with low global QOL. The relationship between emotional functioning in patients with low global QOL and survival needs confirmation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Quality of Life Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROGNOSIS
KW  - SYMPTOMS
KW  - PATIENTS
KW  - HEALTH
KW  - POPULATION
KW  - QUALITY of life
KW  - EORTC QLQ-C30
KW  - multicentre trials
KW  - prognosis
KW  - quality of life
N1  - Accession Number: 11501078; Dancey, J. 1 Zee, B. 1 Osoba, D. 2 Whitehead, M. 1 Lu, F. 1 Kaizer, L. 3 Latreille, J. 4 Pater, J. L. 1; Affiliation:  1: National Cancer institute of Canada Clinical Trials Group, Kingston, Canada  2: British Columbia Cancer Agency and University of British Columbia, Vancouver, Canada  3: Credit Valley Hospital and University of Toronto, Mississauga, Canada  4: Hotel Dieu de Montreal Hospital and Université de Montreal, Montreal, Canada; Source Info: Mar1997, Vol. 6 Issue 2, p0; Subject Term: PROGNOSIS; Subject Term: SYMPTOMS; Subject Term: PATIENTS; Subject Term: HEALTH; Subject Term: POPULATION; Subject Term: QUALITY of life; Author-Supplied Keyword: EORTC QLQ-C30; Author-Supplied Keyword: multicentre trials; Author-Supplied Keyword: prognosis; Author-Supplied Keyword: quality of life; Number of Pages: 0p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Osoba, D.
AU  - Aaronson, N.
AU  - Zee, B.
AU  - Sprangers, M.
AU  - te Velde, A.
T1  - Modification of the EORTC QLQ-C30 (version 2.0) based on content validity and reliability testing in large samples of patients with cancer.
JO  - Quality of Life Research
JF  - Quality of Life Research
Y1  - 1997/03//
VL  - 6
IS  - 2
M3  - Article
SP  - 0
EP  - 0
PB  - Springer Science & Business Media B.V.
SN  - 09629343
AB  - A revision of the Quality of Life Questionnaire (QLQ-C30) of the European Organization for Research and Treatment of Cancer (EORTC) was undertaken to improve low internal consistency estimates (Cronbach‘s alpha) and content validity for the role functioning scale and a conceptual difficulty (undue emphasis on physical functioning) in the global quality of life (QOL) scale. The role functioning items were reworded and a four-category response format was substituted for the previous dichotomous format. A new item asking about ‘overall health‘ was substituted for the ‘overall physical condition‘ item in the global QOL domain. The original and new versions were tested at three time points in a total of 1,181 patients with cancer in Canada (n=696) and the Netherlands (n=485). In both samples there was a marked improvement in internal consistency for the role functioning scale (Cronbach‘s alphas ranging from 0.78-0.88) in the new version. In the global QOL scale, the substitution of the new item for the previous one did not alter internal consistency (Cronbach‘s alphas ranging from 0.81-0.92). The revised versions of the role functioning and global QOL domains have been incorporated into the QLQ-C30 (version 2.0). [ABSTRACT FROM AUTHOR]
AB  - Copyright of Quality of Life Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PATIENTS
KW  - HEALTH
KW  - QUALITY of life
KW  - CANCER
KW  - QLQ-C30
KW  - Quality of life
KW  - revisions
N1  - Accession Number: 11501084; Osoba, D. 1; Email Address: dosoba@bccancer.bc.ca Aaronson, N. 2 Zee, B. 3 Sprangers, M. 4 te Velde, A. 2; Affiliation:  1: Quality of Life Program, British Columbia Cancer Agency and the University of British Columbia, Vancouver, Canada  2: Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands  3: Clinical Trials Group, National Cancer Institute of Canada and Queens University, Kingston, Canada  4: Department of Medical Psychology, University of Amsterdam, Amsterdam, The Netherlands; Source Info: Mar1997, Vol. 6 Issue 2, p0; Subject Term: PATIENTS; Subject Term: HEALTH; Subject Term: QUALITY of life; Subject Term: CANCER; Author-Supplied Keyword: QLQ-C30; Author-Supplied Keyword: Quality of life; Author-Supplied Keyword: revisions; Number of Pages: 0p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107270390
T1  - Conceptualizing oral health and oral health-related quality of life.
AU  - Gift HC
AU  - Atchison KA
AU  - Dayton CM
Y1  - 1997/03//
N1  - Accession Number: 107270390. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 8303205. 
KW  - Oral Health
KW  - Quality of Life
KW  - Mouth Diseases -- Epidemiology
KW  - Probability Sample
KW  - Interviews
KW  - Questionnaires
KW  - Cross Sectional Studies
KW  - Surveys
KW  - Oral Hygiene
KW  - Multivariate Statistics
KW  - P-Value
KW  - T-Tests
KW  - Two-Tailed Test
KW  - Factor Analysis
KW  - Analysis of Variance
KW  - Regression
KW  - Age Factors
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 601
EP  - 608
JO  - Social Science & Medicine
JF  - Social Science & Medicine
JA  - SOC SCI MED
VL  - 44
IS  - 5
PB  - Pergamon Press - An Imprint of Elsevier Science
AB  - This investigation considers oral health from a health-related quality of life perspective using a multidimensional concept representing a combination of impairment, function, perceptions, and/or opportunity. A subset of dentate individuals aged 18 and older from a national probability sample of the U.S. was selected for the reported analysis with data available from personal interviews, self-administered questionnaires, and oral examinations. Impairment was represented by clinically assessed active diseases and sequelae of diseases and self-reported acute symptoms. Other domains are represented by self-reported problems with function, perception of control over oral health, satisfaction with teeth, value attributed to oral health, and opportunity to obtain dental care. Principal components analysis with varimax rotation provided a structure to interpret four factors: accumulated oral neglect, self-perceived symptoms and problems, reparable oral diseases, and oral health values and priorities. Approximately 50% of the variance was explained by these four factors. Factor-based scores, envisioned as an index or summary measure representing the combination of variables identified in each factor, were used to assess potential validity. Whites had lower levels of accumulated oral neglect, fewer symptoms, and less reparable oral disease, but similar oral health values, than non-whites. Level of formal education was associated with each of the four factor-based scores. Age was directly associated with accumulated oral neglect, but the youngest age group had significantly more reparable oral diseases. Individuals with a dental visit in the past two years had considerably less accumulated oral neglect, fewer self-perceived problems, less reparable oral disease, and higher values of oral health than those without a dental visit in the past two years. Ordinary least square regressions were performed on each of the four factor-based scores using eight sociodemographic and economic variables. All four regression models were significant, with only the education variable being significant across all models. These analyses provide no evidence for one unique factor representing oral health. Rather, a conceptual framework for oral health appears to be represented by a set of reasonably independent components, including two groups of clinically assessed oral health, which together more fully represent oral health than any one single variable. Conceptualizing and measuring oral health multidimensionally leads us closer to examining it as part of general health.
SN  - 0277-9536
AD  - National Institutes of Health, 45 Center Drive, 3AN-44D, Bethesda, MD 20892-6401
U2  - PMID: 9032828.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107270390&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107338644
T1  - Nonmedical treatment of patients with carotid artery disease: indications for emergent carotid endarterectomy and percutaneous transluminal angioplasty.
AU  - Yasuma Y
Y1  - 1997/03//1997 Mar
N1  - Accession Number: 107338644. Language: English. Entry Date: 19971001. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7906354. 
KW  - Cerebral Ischemia, Transient -- Surgery
KW  - Carotid Stenosis -- Surgery
KW  - Emergency Care
KW  - Endarterectomy, Carotid
KW  - Angioplasty, Balloon
KW  - Angioplasty, Balloon -- Contraindications
KW  - Carotid Stenosis -- Physiopathology
KW  - Rupture, Spontaneous -- Etiology
KW  - Rupture, Spontaneous -- Surgery
SP  - 53
EP  - 62
JO  - Topics in Emergency Medicine
JF  - Topics in Emergency Medicine
JA  - TOP EMERG MED
VL  - 19
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Carotid endarterectomy (CEA) has become an established procedure for the treatment of patients with transient ischemic attacks (TIAs) associated with severe stenosis and/or ulceration in the carotid artery and is the best option in symptomatic patients with 70% to 99% carotid artery stenosis. Percutaneous transluminal angioplasty (PTA) is being extensively and routinely applied to treat arteriosclerotic lesions in pelvic, leg, coronary, and renal arteries. PTA has not been widely accepted for the treatment of supraaortic lesions, especially carotid artery stenosis, because of the danger of cerebral embolism. More recent technical developments, however, have made PTA feasible under restricted conditions. Emergency CEA and PTA of carotid stenoses are still controversial. The pros and cons of emergency surgery and PTA for acute stroke, crescendo TIA, and acute carotid dissection are reviewed. (C) 1997 Aspen Publishers, Inc.
SN  - 0164-2340
AD  - National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107338644&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107338646
T1  - Pathophysiology of focal ischemic injury: an overview.
AU  - Dawson DA
Y1  - 1997/03//1997 Mar
N1  - Accession Number: 107338646. Language: English. Entry Date: 19971001. Revision Date: 20150818. Publication Type: Journal Article; pictorial; review. Journal Subset: Allied Health; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7906354. 
KW  - Cerebral Ischemia -- Physiopathology
KW  - Cerebral Ischemia -- Metabolism
KW  - Stroke -- Physiopathology
KW  - Neurons -- Physiology
KW  - Calcium -- Metabolism
KW  - Neurons -- Metabolism
KW  - Neurons -- Physiopathology
KW  - Amino Acids -- Metabolism
KW  - Free Radicals -- Metabolism
KW  - Nitric Oxide -- Metabolism
KW  - Cell Physiology
KW  - Cerebral Ischemia -- Etiology
KW  - Cerebral Edema -- Etiology
KW  - Arachidonic Acids -- Metabolism
KW  - Vasoconstrictor Agents
KW  - Tumor Necrosis Factor -- Physiology
KW  - Interleukin 1 -- Physiology
KW  - Homeostasis
SP  - 63
EP  - 78
JO  - Topics in Emergency Medicine
JF  - Topics in Emergency Medicine
JA  - TOP EMERG MED
VL  - 19
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Experimental focal ischemia is characterized by a severely ischemic core surrounded by a penumbral zone of more moderately impaired perfusion. Tissue in the core dies of primary energy failure, but secondary events occurring in the penumbra determine whether penumbral tissue will survive or die. These events include rapid elevation of extracellular glutamate and intracellular calcium within neurons, which activates a cascade of degradative enzymatic and oxidative injury. While in the microvasculature, ischemic mediators, including eicosanoids, endothelin-1, free radicals, and proinflammatory cytokines, induce vasoconstriction, heightened vascular permeability, edema formation, and leukocyte adhesion, resulting in microvascular obstruction and secondary ischemic injury. Pharmacologic intervention designed to inhibit some of these key events can successfully reduce ischemic damage. (C) 1997 Aspen Publishers, Inc.
SN  - 0164-2340
AD  - National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107321469
T1  - Urinary outcomes in older adults: research and clinical perspectives.
AU  - Palmer MH
AU  - Czarapata BJR
AU  - Wells TJ
AU  - Newman DK
Y1  - 1997/03//1997 Mar
N1  - Accession Number: 107321469. Language: English. Entry Date: 19970501. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8812256. 
KW  - Urinary Incontinence -- Prevention and Control
KW  - Outcomes (Health Care)
KW  - Epidemiological Research
KW  - Outcomes Research
KW  - Long Term Care
KW  - Urinary Incontinence -- Epidemiology
KW  - Urinary Incontinence -- Therapy
KW  - Bowel and Bladder Management
KW  - Conceptual Framework
KW  - Professional Compliance
KW  - Program Implementation
KW  - Nursing Home Personnel
KW  - Experimental Studies
KW  - Community Living
KW  - United States
KW  - Nursing Outcomes
KW  - Aged
KW  - Aged, 80 and Over
KW  - Inpatients
KW  - Outpatients
KW  - Male
KW  - Female
SP  - 2
EP  - 9
JO  - Urologic Nursing
JF  - Urologic Nursing
JA  - UROL NURS
VL  - 17
IS  - 1
CY  - Pitman, New Jersey
PB  - Society of Urologic Nurses & Associates, Inc.
AB  - There is a need for continued collaboration between clinicians and researchers to further improve urinary continence outcomes. This article presents the perspectives of four nurses who conduct continence research or who have independent continence services practices. Each discusses continence outcomes used in long-term care facilities or the community as a researcher or clinician and suggests implications for future nursing development.
SN  - 1053-816X
AD  - National Institute of Nursing Research, Baltimore, Maryland
U2  - PMID: 9110899.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107321469&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2008-13529-010
AN  - 2008-13529-010
AU  - Maric, Dragan
AU  - Maric, Irina
AU  - Ma, Wu
AU  - Lahojuji, Fatiha
AU  - Somogyi, Roland
AU  - Wen, Xiling
AU  - Sieghart, Werner
AU  - Fritschy, Jean-Marc
AU  - Barker, Jeffery L.
T1  - Anatomical gradients in proliferation and differentiation of embryonic rat cns accessed by buoyant density fractionation: α3, β3 and γ2 GABAA receptor subunit co-expression by post-mitotic neocortical neurons correlates directly with cell buoyancy.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1997/03//
VL  - 9
IS  - 3
SP  - 507
EP  - 522
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Maric, Dragan, Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 2C02, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13529-010. PMID: 9104593 Partial author list: First Author & Affiliation: Maric, Dragan; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cells (Biology); Central Nervous System; Neural Development; Neural Receptors; Neurons. Minor Descriptor: Embryo; Gamma Aminobutyric Acid; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Mar, 1997. 
AB  - Development of the CNS occurs as complex cascade of pre-programmed events involving distinct phases of cell proliferation and differentiation. Here we show these phases correlate with cells of specific buoyant densities which can be readily accessed by density gradient fractionation. Sprague-Dawley dams were pulse-labelled with bromodeoxyuridine (BrdU) and selected regions of embryonic (E) CNS tissues at E11–22 dissociated with papain into single-cell suspensions. Proliferative cell populations were assessed by anti-BrdU and propidium iodide staining using flow cytometry. Cell differentiation was evaluated using molecular and immunocytochemical probes against mRNAs and antigens differentiating the neuroepithelial, neuronal and glial cell lineages. The results show the emergence of distinctive spatiotemporal changes in BrdU+ populations throughout the CNS during embryonic development, which were followed by corresponding changes in the cellular distributions of antigens distinguishing specific cell types. Fractionation of neocortical cells using discontinuous Percoll gradients revealed that an increasing number of cells increase their buoyancy during corticogenesis. Immunocytochemical and molecular characterization showed that the proliferative and progenitor cell populations are for the most part associated with lower buoyancy or higher specific buoyant densities (> 1.056 g/ml) whereas the post-mitotic, differentiated neurons generally separated into fractions of higher buoyancy or lower specific buoyant densities (<1.043 g/ml). Immunostaining with antibodies against several GABAA receptor subunits (α₃, β₃, γ₂) revealed that the highest percent (70–90%) of immunopositive cells could be identified in the most buoyant, differentiating neurons found in the cortical plate/subplate regions, with the lowest percent of the immunopositive cells found in the least buoyant, proliferative and progenitor cell populations originating from the ventricular/subventricular zones. Taken together, these results indicate that buoyant density is distinguishing characteristic of embryonic CNS cells transforming from primarily proliferative to mainly differentiating, and that fractionation of these cells according to their buoyant densities provides rapid access to the properties of specific cell lineages during the prenatal period of CNS development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cell proliferation
KW  - embryonic rat
KW  - central nervous system
KW  - buoyant density fractionation
KW  - gamma aminobutyric acid
KW  - neural receptors
KW  - neurons
KW  - cells
KW  - prenatal period
KW  - 1997
KW  - Cells (Biology)
KW  - Central Nervous System
KW  - Neural Development
KW  - Neural Receptors
KW  - Neurons
KW  - Embryo
KW  - Gamma Aminobutyric Acid
KW  - Rats
KW  - 1997
DO  - 10.1111/j.1460-9568.1997.tb01628.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105823367
T1  - Route of immunization and the therapeutic impact of recombinant anticancer vaccines.
AU  - Irvine KR
AU  - Chamberlain RS
AU  - Shulman EP
AU  - Rosenberg SA
AU  - Restifo NP
AU  - Irvine, K R
AU  - Chamberlain, R S
AU  - Shulman, E P
AU  - Rosenberg, S A
AU  - Restifo, N P
Y1  - 1997/03/05/
N1  - Accession Number: 105823367. Language: English. Entry Date: 20080307. Revision Date: 20161118. Publication Type: journal article; review. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Z01 BC010763-01//Intramural NIH HHS/United States. NLM UID: 7503089. 
KW  - Cancer Vaccines -- Administration and Dosage
KW  - Neoplasms -- Prevention and Control
KW  - Animals
KW  - Injections, Intramuscular
KW  - Injections, Intravenous
KW  - Recombinant Proteins -- Administration and Dosage
SP  - 390
EP  - 392
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 5
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Surgery Branch, National Cancer Institute, Bethesda, MD, USA
AD  - Surgery Branch, National Cancer Institute, Bethesda, MD, USA.
U2  - PMID: 9060962.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105823367&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
ID  - 107265867
T1  - Medical literature made easy. Querying databases on the Internet.
AU  - Sikorski R
AU  - Peters R
AU  - Sikorski, R
AU  - Peters, R
Y1  - 1997/03/26/
N1  - Accession Number: 107265867. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: directories; website. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Medline
KW  - World Wide Web
KW  - Computerized Literature Searching
KW  - United States
KW  - Medlars
KW  - National Library of Medicine (U.S.) -- United States
KW  - Access to Information
KW  - Information Retrieval
KW  - Database Vendors
SP  - 959
EP  - 960
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 277
IS  - 12
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - National Cancer Institute, Bethesda, Md. 20892, USA
AD  - Bldg 49, Room 4B56, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 9091660.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107265867&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Curtis, Rochelle E.
AU  - Rowlings, Philip A.
AU  - Deeg, H. Joachim
AU  - Shriner, Donna A.
AU  - Socié, Gérard
AU  - Travis, Lois B.
AU  - Horowitz, Mary M.
AU  - Witherspoon, Robert P.
AU  - Hoover, Robert N.
AU  - Sobocinski, Kathleen A.
AU  - Fraumeni, Joseph F.
AU  - Boice, John D.
AU  - Schoch, H. Gary
AU  - Sale, George E.
AU  - Storb, Rainer
AU  - Travis, William D.
AU  - Kolb, Hans-Jochem
AU  - Gale, Robert Peter
AU  - Passweg, Jakob R.
AU  - Curtis, R E
T1  - Solid cancers after bone marrow transplantation.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997/03/27/
VL  - 336
IS  - 13
M3  - journal article
SP  - 897
EP  - 904
SN  - 00284793
AB  - <bold>Background: </bold>The late effects of bone marrow transplantation, including cancer, need to be determined in a large population at risk.<bold>Methods: </bold>We studied 19,229 patients who received allogeneic transplants (97.2 percent) or syngeneic transplants (2.8 percent) between 1964 and 1992 at 235 centers to evaluate the risk of the development of a new solid cancer. Risk factors relating to the patient, the transplant, and the course after transplantation were evaluated.<bold>Results: </bold>The transplant recipients were at significantly higher risk of new solid cancers than the general population (observed cases, 80; ratio of observed to expected cases, 2.7; P<0.001). The risk was 8.3 times higher than expected among those who survived 10 or more years after transplantation. The cumulative incidence rate was 2.2 percent (95 percent confidence interval, 1.5 to 3.0 percent) at 10 years and 6.7 percent (95 percent confidence interval, 3.7 to 9.6 percent) at 15 years. The risk was significantly elevated (P<0.05) for malignant melanoma (ratio of observed to expected cases, 5.0) and cancers of the buccal cavity (11.1), liver (7.5), brain or other parts of the central nervous system (7.6), thyroid (6.6), bone (13.4), and connective tissue (8.0). The risk was higher for recipients who were younger at the time of transplantation than for those who were older (P for trend <0.001). In multivariate analyses, higher doses of total-body irradiation were associated with a higher risk of solid cancers. Chronic graft-versus-host disease and male sex were strongly linked with an excess risk of squamous-cell cancers of the buccal cavity and skin.<bold>Conclusions: </bold>Patients undergoing bone marrow transplantation have an increased risk of new solid cancers later in life. The trend toward an increased risk over time after transplantation and the greater risk among younger patients indicate the need for life-long surveillance. [ABSTRACT FROM AUTHOR]
AB  - Copyright of New England Journal of Medicine is the property of New England Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER -- Risk factors
KW  - BONE marrow -- Transplantation
KW  - LEUKEMIA -- Treatment
KW  - BLOOD diseases -- Treatment
KW  - AGE distribution (Demography)
KW  - ANALYSIS of variance
KW  - GRAFT versus host disease
KW  - LONGITUDINAL method
KW  - RADIATION -- Dosage
KW  - RADIATION carcinogenesis
KW  - RADIOTHERAPY
KW  - REGRESSION analysis
KW  - TIME
KW  - DISEASE incidence
KW  - SECONDARY primary tumors
KW  - DISEASE complications
N1  - Accession Number: 24937601; Curtis, Rochelle E. Rowlings, Philip A. Deeg, H. Joachim Shriner, Donna A. Socié, Gérard Travis, Lois B. Horowitz, Mary M. Witherspoon, Robert P. Hoover, Robert N. Sobocinski, Kathleen A. Fraumeni, Joseph F. Boice, John D. Schoch, H. Gary Sale, George E. Storb, Rainer Travis, William D. Kolb, Hans-Jochem Gale, Robert Peter Passweg, Jakob R. Curtis, R E 1; Affiliation:  1: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA; Source Info: 03/27/97, Vol. 336 Issue 13, p897; Subject Term: CANCER -- Risk factors; Subject Term: BONE marrow -- Transplantation; Subject Term: LEUKEMIA -- Treatment; Subject Term: BLOOD diseases -- Treatment; Subject Term: AGE distribution (Demography); Subject Term: ANALYSIS of variance; Subject Term: GRAFT versus host disease; Subject Term: LONGITUDINAL method; Subject Term: RADIATION -- Dosage; Subject Term: RADIATION carcinogenesis; Subject Term: RADIOTHERAPY; Subject Term: REGRESSION analysis; Subject Term: TIME; Subject Term: DISEASE incidence; Subject Term: SECONDARY primary tumors; Subject Term: DISEASE complications; Number of Pages: 8p; Document Type: journal article; Full Text Word Count: 5186
L3  - 10.1056/NEJM199703273361301
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 24937601
T1  - Solid cancers after bone marrow transplantation.
AU  - Curtis, Rochelle E.
AU  - Rowlings, Philip A.
AU  - Deeg, H. Joachim
AU  - Shriner, Donna A.
AU  - Socié, Gérard
AU  - Travis, Lois B.
AU  - Horowitz, Mary M.
AU  - Witherspoon, Robert P.
AU  - Hoover, Robert N.
AU  - Sobocinski, Kathleen A.
AU  - Fraumeni, Joseph F.
AU  - Boice, John D.
AU  - Schoch, H. Gary
AU  - Sale, George E.
AU  - Storb, Rainer
AU  - Travis, William D.
AU  - Kolb, Hans-Jochem
AU  - Gale, Robert Peter
AU  - Passweg, Jakob R.
AU  - Curtis, R E
Y1  - 1997/03/27/
N1  - Accession Number: 24937601. Language: English. Entry Date: 19980401. Revision Date: 20160507. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Bone Marrow Transplantation -- Adverse Effects
KW  - Neoplasms, Second Primary -- Etiology
KW  - Incidence
KW  - Male
KW  - Analysis of Variance
KW  - Regression
KW  - Neoplasms, Second Primary -- Epidemiology
KW  - Leukemia -- Therapy
KW  - Time Factors
KW  - Graft Versus Host Disease -- Complications
KW  - Radiotherapy -- Adverse Effects
KW  - Female
KW  - Radiation Dosage
KW  - Hematologic Diseases -- Therapy
KW  - Prospective Studies
KW  - Adolescence
KW  - Adult
KW  - Risk Factors
KW  - Child
KW  - Age Factors
KW  - Neoplasms, Radiation-Induced -- Etiology
KW  - Human
SP  - 897
EP  - 904
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 336
IS  - 13
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
AB  - Background: The late effects of bone marrow transplantation, including cancer, need to be determined in a large population at risk.Methods: We studied 19,229 patients who received allogeneic transplants (97.2 percent) or syngeneic transplants (2.8 percent) between 1964 and 1992 at 235 centers to evaluate the risk of the development of a new solid cancer. Risk factors relating to the patient, the transplant, and the course after transplantation were evaluated.Results: The transplant recipients were at significantly higher risk of new solid cancers than the general population (observed cases, 80; ratio of observed to expected cases, 2.7; P<0.001). The risk was 8.3 times higher than expected among those who survived 10 or more years after transplantation. The cumulative incidence rate was 2.2 percent (95 percent confidence interval, 1.5 to 3.0 percent) at 10 years and 6.7 percent (95 percent confidence interval, 3.7 to 9.6 percent) at 15 years. The risk was significantly elevated (P<0.05) for malignant melanoma (ratio of observed to expected cases, 5.0) and cancers of the buccal cavity (11.1), liver (7.5), brain or other parts of the central nervous system (7.6), thyroid (6.6), bone (13.4), and connective tissue (8.0). The risk was higher for recipients who were younger at the time of transplantation than for those who were older (P for trend <0.001). In multivariate analyses, higher doses of total-body irradiation were associated with a higher risk of solid cancers. Chronic graft-versus-host disease and male sex were strongly linked with an excess risk of squamous-cell cancers of the buccal cavity and skin.Conclusions: Patients undergoing bone marrow transplantation have an increased risk of new solid cancers later in life. The trend toward an increased risk over time after transplantation and the greater risk among younger patients indicate the need for life-long surveillance.
SN  - 0028-4793
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
U2  - PMID: 9070469.
DO  - 10.1056/NEJM199703273361301
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107330144
T1  - Ad libitum food intake in humans after manipulation of glycogen stores.
AU  - Snitker S
AU  - Larson DE
AU  - Tataranni PA
AU  - Ravussin E
Y1  - 1997/04//
N1  - Accession Number: 107330144. Language: English. Entry Date: 19970701. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Glycogen -- Metabolism
KW  - Energy Metabolism -- Physiology
KW  - Dietary Carbohydrates -- Pharmacodynamics
KW  - Eating -- Physiology
KW  - Energy Intake
KW  - Dietary Carbohydrates -- Metabolism
KW  - Calorimetry
KW  - Exercise Physiology
KW  - Glucose -- Administration and Dosage
KW  - Glucose -- Metabolism
KW  - Muscle, Skeletal
KW  - Respiration -- Physiology
KW  - Crossover Design
KW  - Analysis of Variance
KW  - Repeated Measures
KW  - Data Analysis Software
KW  - Correlation Coefficient
KW  - Adult
KW  - Male
KW  - Human
SP  - 941
EP  - 946
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 65
IS  - 4
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - It is controversial whether food intake in humans is under day-to-day regulation to maintain constant body glycogen stores. In eight white males with a mean (+/- SD) age of 30 +/- 4 y, body weight of 82 +/- 20 kg, and percentage body fat of 22 +/- 5%, exercise and diets were used to produce either high (HG) or low glycogen (LG) stores in a randomized crossover design. After each treatment a vastus lateralis muscle biopsy was obtained. Subsequent ad libitum food intake was measured with an automated food-selection system during 2 d in a respiratory chamber. Despite a 46 +/- 21% difference in muscle glycogen between the two treatments, ad libitum 2-d food intakes (energy, weight, or macronutrients) were similar between treatments (HG: 23.80 +/- 4.67 MJ/d; LG: 21.20 +/- 6.73 MJ/d). However, energy intake on the second day of ad libitum feeding was negatively correlated with carbohydrate balance on the first day, adjusted for the effect of total energy intake and treatment. Adjusted carbohydrate balance on day 1 only explained 9% of the variance in energy intake on day 2. The 24-h respiratory quotient on the first day after treatment was higher after the HG than after the LG treatment: 0.94 +/- 0.04 and 0.88 +/- 0.07 (P < 0.001). The findings suggest that 1) body glycogen stores play at most a minor role in short-term food intake regulation, and 2) in the short term, imbalances in glycogen stores are corrected by adjustments of macronutrient oxidation rates. (C) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix
U2  - PMID: 9094876.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Green, Sylvan B.
T1  - Editorial: The Eating Patterns Study--The Importance of Practical Randomized Trials in Communities.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/04//
VL  - 87
IS  - 4
M3  - Editorial
SP  - 541
EP  - 543
PB  - American Public Health Association
SN  - 00900036
AB  - The author comments on the results of the Eating Patterns Study which evaluated the effectiveness of the intervention in lowering reported dietary fat intake in a primary care practice setting. The relevance of the study resides in part of its being a randomized trial and that it sought to address the question of whether practical randomized trials in communities are effective in investigating eating patterns. The study also investigated a self-reported behavioral outcome but did not attempt to assess disease outcomes.
KW  - FOOD habits
KW  - FOOD -- Fat content
KW  - RANDOMIZED controlled trials
KW  - PRIMARY care (Medicine)
KW  - HEALTH behavior
KW  - ATTITUDES toward health
N1  - Accession Number: 20709043; Green, Sylvan B. 1; Affiliation:  1: National Cancer Institute, Bethesda, Md.; Source Info: Apr97, Vol. 87 Issue 4, p541; Subject Term: FOOD habits; Subject Term: FOOD -- Fat content; Subject Term: RANDOMIZED controlled trials; Subject Term: PRIMARY care (Medicine); Subject Term: HEALTH behavior; Subject Term: ATTITUDES toward health; Number of Pages: 3p; Document Type: Editorial
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DB  - aph
ER  - 

TY  - JOUR
AU  - Lewis, Cora E.
AU  - Smith, Delia E.
AU  - Wallace, Dennis D.
AU  - Williams, O. Dale
AU  - Bild, Diane E.
AU  - Jacobs Jr., David R.
T1  - Seven-Year Trends in Body Weight and Associations with Lifestyle and Behavioral Characteristics in Black and White Young Adults: The CARDIA Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/04//
VL  - 87
IS  - 4
M3  - Article
SP  - 635
EP  - 642
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study estimated the amount of weight change in a biracial cohort of young adults and the separate components attributable to time-related and aging-related changes, as well as identified possible determinants of weight change. Methods. In this population-based prospective study of 18- to 30-year-old African-American and White men and women, body weight and prevalence of overweight were measured from 1985/86 to 1992/93. Results. Average weight increased over the 7 years, increases ranging from 5.2 kg (SE = 0.2, n = 811) in White women to 8.5 kg (SE = 0.3, n = 882) in African-American women. Significant time-related increases in weight, ranging from 2.0 kg (SE = 1.0) in White women to 4.8 kg (SE = 1.0, n = 711) in African-American men, accounted for 40% to 60% of the average total weight gain. Aging-related increases were also significant, ranging from 2.6 kg (SE = 0.8, n = 944) in White men to 5.0 kg (SE = 1.1) in African-American women. The prevalence of overweight increased progressively in each group. Decreased physical fitness was most strongly associated with weight gain in both sexes. Conclusions. The observed dramatic time-related weight gains, most likely due to secular (period-related) trends, are a serious public health concern. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BODY weight
KW  - AGE factors in disease
KW  - AFRICAN Americans -- Diseases
KW  - WHITES
KW  - DISEASES
KW  - YOUNG adults -- Diseases
KW  - UNITED States
N1  - Accession Number: 9705292377; Lewis, Cora E. 1 Smith, Delia E. 1 Wallace, Dennis D. 2 Williams, O. Dale 2 Bild, Diane E. 3 Jacobs Jr., David R. 4; Affiliation:  1: Division of Preventive Medicine, School of Medicine, University of Alabama, Birmingham  2: Department of Biostatistics, School of Public Health, University of Alabama, Birmingham  3: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, Md.  4: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis; Source Info: Apr97, Vol. 87 Issue 4, p635; Subject Term: BODY weight; Subject Term: AGE factors in disease; Subject Term: AFRICAN Americans -- Diseases; Subject Term: WHITES; Subject Term: DISEASES; Subject Term: YOUNG adults -- Diseases; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article; Full Text Word Count: 6271
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Voorhees, Carolyn C.
AU  - Swank, Robert T.
AU  - Stillman, Frances A.
AU  - Harris, Donna X.
AU  - Watson Jr., Herbert W.
AU  - Becker, Diane M.
T1  - Cigarette Sales to African-American and White Minors in Low-Income Areas of Baltimore.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/04//
VL  - 87
IS  - 4
M3  - Article
SP  - 652
EP  - 654
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study documented illegal sales of cigarettes to minors in low-income African-American and White urban areas in East Baltimore. Methods. Six youths, aged 14 through 16 years, were sent to a random sample of 83 corner stores to attempt to purchase cigarettes. The youths provided the investigators with data on merchant, store, and purchase characteristics. Results. The youths successfully purchased cigarettes in 85.5% of the stores; 58% of the stores displayed five or more cigarette advertisements outside their premises. Conclusions. Cigarette sales to minors and associated advertising remain prevalent in this urban community. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIGARETTES -- Marketing
KW  - YOUTH -- Substance use
KW  - CIGARETTE smokers
KW  - CIGARETTE vendors
KW  - BALTIMORE (Md.)
KW  - MARYLAND
N1  - Accession Number: 9705292381; Voorhees, Carolyn C. 1 Swank, Robert T. Stillman, Frances A. 2 Harris, Donna X. 3 Watson Jr., Herbert W. Becker, Diane M.; Affiliation:  1: National Heart, Lung and Blood Institute, Division of Epidemiology and Clinical Applications, 6701 Rockledge, MSC 7936, Rm 8215, Bethesda, MD 20892  2: National Cancer Institute, Division of Cancer Prevention and Control  3: State of Maryland, Department of Health; Source Info: Apr97, Vol. 87 Issue 4, p652; Subject Term: CIGARETTES -- Marketing; Subject Term: YOUTH -- Substance use; Subject Term: CIGARETTE smokers; Subject Term: CIGARETTE vendors; Subject Term: BALTIMORE (Md.); Subject Term: MARYLAND; NAICS/Industry Codes: 454390 Other Direct Selling Establishments; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 2613
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107327294
T1  - Programmed instruction: genetics and gene therapy. Genes and inheritance.
AU  - Middelton LA
AU  - Peters KF
AU  - Helmbold EA
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 107327294. Language: English. Entry Date: 19970601. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; pictorial; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Genetics, Medical
KW  - Chromosomes
KW  - Genes
KW  - DNA
KW  - Hereditary Diseases
KW  - Chromosome Disorders
KW  - Education, Continuing (Credit)
KW  - Family History
KW  - RNA
KW  - Human Genome Project
KW  - Male
KW  - Female
SP  - 129
EP  - 151
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 20
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The information gained from the Human Genome Project and related genetic research will undoubtedly create significant changes in health care practice. It is becoming increasingly clear that nurses in all areas of clinical practice will require a fundamental understanding of basic genetics. This self-learning module provides the oncology nurse with an overview of basic genetic concepts including inheritance patterns of single gene conditions, pedigree construction, chromosome aberrations, and the multifactorial basis underlying many common diseases of adulthood. Normal gene structure and function will be introduced and the biochemistry of genetic errors will be described.
SN  - 0162-220X
AD  - National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9145562.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107178270
T1  - Urologic implications of cancer vaccines.
AU  - Khleif SN
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 107178270. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8912618. 
KW  - Immunotherapy
KW  - Neoplasms -- Drug Therapy
SP  - 53
EP  - 60
JO  - Contemporary Urology
JF  - Contemporary Urology
JA  - CONTEMP UROL
VL  - 9
IS  - 4
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Immunotherapy is potentially the fourth modality for the treatment of cancer along with surgery, radiation therapy, and chemotherapy. As our understanding of host defense mechanisms against cancer grows, clinical applications for immunization will increase.
SN  - 1042-2250
AD  - Senior Clinical Investigator, National Cancer Institute, Medicine Branch, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Majumder, Sadhan
AU  - Zhao, Zhaoyang
AU  - Kaneko, Kotaro
AU  - Melvin L. DePamphilis
T1  - Developmental acquisition of enhancer function requires a unique coactivator activity.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/04//4/1/97
VL  - 16
IS  - 7
M3  - Article
SP  - 1721
EP  - 1731
SN  - 02614189
AB  - Enhancers are believed to stimulate promoters by relieving chromatin-mediated repression. However, injection of plasmid­encoded genes into mouse oocytes and embryos revealed that enhancers failed to stimulate promoters prior to formation of a two-cell embryo, even though the promoter was repressed in the maternal nucleus of both oocytes and one-cell embryos. The absence of enhancer function was not due to the absence of a required sequence-specific enhancer activation protein, because enhancer function was not elicited even when these proteins either were provided by an expression vector (GAL4:VP16) or were present as an endogenous transcription factor (TEF-1) and shown to be active in stimulating promoters. Instead, enhancer function in vivo required a unique coactivator activity in addition to enhancer-specific DNA binding proteins and promoter repression. This coactivator activity first appeared during mouse development in two- to four-cell embryos, concurrent with the major onset of zygotic gene expression. Competition between various enhancers was observed in these embryos, but not competition between enhancers and promoters, and competition between enhancers was absent in one-cell embryos. Moreover, enhancer function in oocytes could be partially restored by pre-injecting mRNA from cells in which enhancers were active, the same mRNA did not affect enhancer function in two- to four-cell embryos. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROMOTERS (Genetics)
KW  - EMBRYOS
KW  - PROTEINS
KW  - GENE expression
KW  - GENETIC vectors
KW  - DNA-binding proteins
KW  - TRANSCRIPTION factors
KW  - coactivators
KW  - enhancers
KW  - mouse development
KW  - transcription
KW  - zygotic gene activation
N1  - Accession Number: 13005403; Majumder, Sadhan 1 Zhao, Zhaoyang 1 Kaneko, Kotaro 2 Melvin L. DePamphilis 2; Affiliation:  1: University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 100, Houston, TX 77030, USA  2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2753, USA; Source Info: 4/1/97, Vol. 16 Issue 7, p1721; Subject Term: PROMOTERS (Genetics); Subject Term: EMBRYOS; Subject Term: PROTEINS; Subject Term: GENE expression; Subject Term: GENETIC vectors; Subject Term: DNA-binding proteins; Subject Term: TRANSCRIPTION factors; Author-Supplied Keyword: coactivators; Author-Supplied Keyword: enhancers; Author-Supplied Keyword: mouse development; Author-Supplied Keyword: transcription; Author-Supplied Keyword: zygotic gene activation; Number of Pages: 11p; Document Type: Article
L3  - 10.1093/emboj/16.7.1721
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104793939
T1  - Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator.
AU  - Desai, A
AU  - Shankar, S K
AU  - Jayakumar, P N
AU  - Chandramuki, A
AU  - Gourie-Devi, M
AU  - Ravikumar, B V
AU  - Ravi, V
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 104793939. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737. 
KW  - Brain Diseases -- Complications
KW  - Cysticercosis -- Complications
KW  - Encephalitis, Arbovirus -- Complications
KW  - Adolescence
KW  - Brain Diseases -- Diagnosis
KW  - Child
KW  - Child, Preschool
KW  - Cysticercosis -- Diagnosis
KW  - Encephalitis, Arbovirus -- Diagnosis
KW  - Female
KW  - Human
KW  - Incidence
KW  - Male
KW  - Predictive Value of Tests
KW  - Prognosis
KW  - Survival Analysis
KW  - Tomography, X-Ray Computed
SP  - 165
EP  - 171
JO  - Epidemiology & Infection
JF  - Epidemiology & Infection
JA  - EPIDEMIOL INFECT
VL  - 118
IS  - 2
PB  - Cambridge University Press
AB  - In this study, we investigated the frequency of co-existence of cerebral cysticercosis (CC) in Japanese encephalitis (JE) cases with special emphasis on its role in predicting the final clinical outcome. Amongst the 163 confirmed cases of JE, 37.42% (61/163) had co-existent CC. This was confirmed by antibody detection in the CSF of 45 cases, CT scan of the brain in 6 cases and at autopsy in 3 cases. In 2 cases confirmation was possible by CT scan as well as at autopsy, in 4, CSF antibody levels and CT scan were suggestive of CC while in 1, CSF antibodies and autopsy were suggestive of CC The co-occurrence of Cysticercus cellulosae in the brain emerged as a prognosticator of poor outcome in JE cases (P < 0.03).
SN  - 0950-2688
AD  - Department of Neurovirology, National Institute of Mental Health & Neuro Sciences, Bangalore.
U2  - PMID: 9129593.
DO  - 10.1017/S0950268896007327
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - O'Keefe, Barry R.
AU  - Beutler, John a.
AU  - Cardellina II, John H.
AU  - Gulakowski, Robert J.
AU  - Krepps, Benjamin L.
AU  - McMahon, James B.
AU  - Sowders II, Raymond C.
AU  - Henderson, Louise E.
AU  - Pannell, Lewis K.
AU  - Pomponi, Shirley A.
AU  - Boyd, Michael R.
T1  - Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge <em>Niphates erecta</em>.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/04//4/1/97
VL  - 245
IS  - 1
M3  - Article
SP  - 47
EP  - 53
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Anti-human immunodeficiency virus (HIV)-bioassay-guided fractionation of aqueous extracts of the Caribbean sponge Niphates erecta led to isolation of a novel anti-HIV protein, named niphatevirin. The protein was purified to homogeneity by ethanol precipitation, ammonium sulfate precipitation, gel-permeation chromatography and concanavalin-A—Sepharose affinity chromatography. Niphatevifin potently inhibited the cytopathic effects of HIV-1 infection in cultured human lymphoblastoid (CEM-SS) cells; the effective concentration of drug that results in 50% protection of the cells through inhibition of ceil lethality, cell-cell fusion and syncytium formation was approximately 10 nM. Delay of addition of niphatevirin to infected cultures by two hours markedly decreased (≈50%) cytoprotection; delay of addition by eight hours resulted in no antiviral activity. Niphatevirin bound to CD4 in a manner that prevented the binding of gp120, but did not directly bind gp120. Niphatevifin (6.5 μM) was inactive in both hemagglutination and hemolysis assays. Niphatevirin had a molecular mass of about 19 kDa by matrix-assisted laser-desorption ionization-time of flight (MALDI-TOF) mass spectrometry, and a native molecular mass of approximately 18 kDa by gel-fltration chromatography. The protein had an acidic isoelectric point of 4.2–4.6, and was shown by periodate acid Schiff's staining to be glycosylated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLYCOPROTEINS
KW  - PROTEINS
KW  - HIV antibodies
KW  - VIRAL antibodies
KW  - SPONGES (Invertebrates)
KW  - INVERTEBRATES
KW  - CD4 antigen
KW  - VIRAL receptors
KW  - anti-(human immunodeficiency virus)
KW  - cd4
KW  - glycoprotein
KW  - niphates erecta
KW  - sponge
N1  - Accession Number: 12616247; O'Keefe, Barry R. 1 Beutler, John a. 1 Cardellina II, John H. 1 Gulakowski, Robert J. 1 Krepps, Benjamin L. 1 McMahon, James B. 1 Sowders II, Raymond C. 2 Henderson, Louise E. 2 Pannell, Lewis K. 3 Pomponi, Shirley A. 4 Boyd, Michael R. 1; Affiliation:  1: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Programs, Division of Cancer Treatment, Diagnosis, and Centers, Frederick Cancer Research and Development Center, Maryland, USA  2: AIDS Vaccine Program, S.A.I.C.-Frederick, NCI-Frederick Cancer Research and Development Center, Maryland, USA  3: Laboratory of Analytical Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Maryland, USA  4: Division of Biomedical Marime Reasearch, Harbor Branch Oceanographic Institute, Florida, USA; Source Info: 4/1/97, Vol. 245 Issue 1, p47; Subject Term: GLYCOPROTEINS; Subject Term: PROTEINS; Subject Term: HIV antibodies; Subject Term: VIRAL antibodies; Subject Term: SPONGES (Invertebrates); Subject Term: INVERTEBRATES; Subject Term: CD4 antigen; Subject Term: VIRAL receptors; Author-Supplied Keyword: anti-(human immunodeficiency virus); Author-Supplied Keyword: cd4; Author-Supplied Keyword: glycoprotein; Author-Supplied Keyword: niphates erecta; Author-Supplied Keyword: sponge; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 7p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Skaleriˇ, Uroš
AU  - Kramar, Barbara
AU  - Petelin, Milan
AU  - Pavlica, Zlatko
AU  - Wahl, Sharon M.
T1  - Changes in TGF-β1 levels in gingiva, crevicular fluid and serum associated with periodontal inflammation in humans and dogs.
JO  - European Journal of Oral Sciences
JF  - European Journal of Oral Sciences
Y1  - 1997/04//
VL  - 105
IS  - 2
M3  - Article
SP  - 136
EP  - 142
SN  - 09098836
AB  - Transforming growth factor-beta (TGF-β) represents a family of polypeptide growth factors, involved in embryogenesis, inflammation, regulation of immune responses and wound healing. To determine whether TGF-β contributes to the evolution of periodontal disease, we assayed TGF-β levels in gingiva and crevicular fluid of patients with gingivitis and periodontitis. In parallel, TGF-β was quantified in gingival fluid and serum of beagles with experimentally-induced periodontitis. Disease was monitored by several clinical parameters including Plaque Index, Gingival Index, probing depth, and epithelial attachment loss. Gingival tissues were obtained from 9 patients at the time of periodontal surgery, and gingival fluid samples were collected from an additional population of 10 periodontal patients. In 14 beagles, experimental periodontitis was induced and gingival fluids collected 6 months later. Fluid was collected by paper strips and volume measured by Periotron. Additionally, sera was collected before and 9 months after the ligature-induced periodontitis in 7 beagles. The levels of TGF-β1 were measured by ELISA. In the patients, a significantly higher concentration of TGF-β1 was observed both in the gingival tissues and fluid samples obtained from the sites with deeper periodontal pockets than in the less involved sites. In beagles, TGF-β1 levels measured in gingival fluid were elevated in moderate disease, declining in fluid samples obtained from the pockets during more advanced experimental periodontitis. Furthermore, with the progression of experimental periodontitis, a decrease in TGF-β1 occurred in the sera of the beagle dogs. These data suggest that TGF-β1 may play a role in the pathogenesis and diagnosis of periodontal disease, and that its actions can be further explored in an animal model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Oral Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GINGIVAL fluid
KW  - GUMS
KW  - SERUM
KW  - BLOOD plasma
KW  - PERIODONTAL disease
KW  - GINGIVITIS
KW  - crevicular fluid
KW  - gingiva
KW  - periodontal disease
KW  - serum
KW  - TGF-β1
N1  - Accession Number: 12854636; Skaleriˇ, Uroš 1; Email Address: skaleric@ibmi.mf.uni-ij.si Kramar, Barbara 1 Petelin, Milan 1 Pavlica, Zlatko 2 Wahl, Sharon M. 3; Affiliation:  1: Department of Oral Medicine and Periodontology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.  2: Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana, Ljubljana, Sbvenia.  3: Celluiar Immunology Section, Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1997, Vol. 105 Issue 2, p136; Subject Term: GINGIVAL fluid; Subject Term: GUMS; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: PERIODONTAL disease; Subject Term: GINGIVITIS; Author-Supplied Keyword: crevicular fluid; Author-Supplied Keyword: gingiva; Author-Supplied Keyword: periodontal disease; Author-Supplied Keyword: serum; Author-Supplied Keyword: TGF-β1; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mekori, Y. A.
AU  - Oh, C. K.
AU  - Dastych, J.
AU  - Goff, J. P.
AU  - Adachi, S.
AU  - Bianchine, P. J.
AU  - Worobec, A.
AU  - Semere, T.
AU  - Pierce, J. H.
AU  - Metcalfe, D. D.
T1  - Characterization of a mast cell line that lacks the extracellular domain of membrane c-kit.
JO  - Immunology
JF  - Immunology
Y1  - 1997/04//
VL  - 90
IS  - 4
M3  - Article
SP  - 518
EP  - 525
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Expression of the c-kit proto-oncogene receptor on mast cells is essential for their normal proliferation and maturation as well as for several biological responses such as chemotaxis and attachment. In the present study we report that the interleukin-3 (IL-3)-dependent mast cell line CFTL-15 lacks the extracellular domain of the c-kit receptor. This observation was made after noting that the c-kit ligand stein cell factor (SCF) could not prevent IL-3 deprivation-induced mast cell apoptosis and that CFTL-15 cells did not proliferate in response to SCF. Flow cytometric analysis employing monoclonal antic-kit antibodies, and immunogold labelling with analysis by electron microscopy, subsequently showed a diminished expression of c-kit on CFTL-15 cells. There was no identifiable message for the extracellular domain of c-kit in these cells, as determined by reverse transcriptase-polymerse chain reaction (RT-PCR). These previously unrecognized properties of the CFTL- 15 mast cell line allowed the examination of other biological consequences of the lack of c-kit on mast cells. Analysing the ability of these cells to adhere to surface-bound fibronectin, it was found that addition of SCF did not increase their adhesion to this substrate, in opposition to what is reported with other mast cells. Similarly, CFTL-15 mast cells did not adhere to fibroblasts, which is known to require c-kit expression. Also, there was no protein tyrosine phosphorylation in these cells in response to SCF. CFTL-15 cells underwent apoptosis on removal of IL-3 coincident with a decrease in endogenous Bcl-2 mRNA. Overexpression of Bcl-2 cDNA prolonged survival of Bcl-2-transfected CFTL-l5 cells upon withdrawal of IL-3. Thus, the CFTL-15 cell line that lacks surface c-kit is not able to proliferate in response to SCF, undergoes apoptosis in the presence of SCF, and does not adhere to fibroblasts. These results confirm earlier studies on the functional consequences of c-kit and provide a novel experimental model for further Investigation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ONCOGENES
KW  - MAST cells
KW  - CELL proliferation
KW  - ELECTRON microscopy
KW  - REVERSE transcriptase
KW  - AMINO acids
N1  - Accession Number: 14074053; Mekori, Y. A. 1,2 Oh, C. K. 1 Dastych, J. 1 Goff, J. P. 3 Adachi, S. 1 Bianchine, P. J. 1 Worobec, A. 1 Semere, T. 1 Pierce, J. H. 4 Metcalfe, D. D. 1; Affiliation:  1: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD  2: The Department of Medicine, Meir General Hospital Kfar-Saba and the Sackler School of Medicine, Tel-Aviv University, Israel  3: Radiation Oncology Research Division, University of Pittsburgh, Pittsburgh, PA, USA  4: National Cancer Institute, National Institutes of Health, Bethesda, MD; Source Info: Apr97, Vol. 90 Issue 4, p518; Subject Term: ONCOGENES; Subject Term: MAST cells; Subject Term: CELL proliferation; Subject Term: ELECTRON microscopy; Subject Term: REVERSE transcriptase; Subject Term: AMINO acids; Number of Pages: 8p; Document Type: Article
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ER  - 

TY  - JOUR
ID  - 105822531
T1  - Phase II trial of suramin, leuprolide, and flutamide in previously untreated metastatic prostate cancer.
AU  - Dawson NA
AU  - Figg WD
AU  - Cooper MR
AU  - Sartor O
AU  - Bergan RC
AU  - Senderowicz AM
AU  - Steinberg SM
AU  - Tompkins A
AU  - Weinberger B
AU  - Sausville EA
AU  - Reed E
AU  - Myers CE
AU  - Dawson, N A
AU  - Figg, W D
AU  - Cooper, M R
AU  - Sartor, O
AU  - Bergan, R C
AU  - Senderowicz, A M
AU  - Steinberg, S M
AU  - Tompkins, A
Y1  - 1997/04//
N1  - Accession Number: 105822531. Language: English. Entry Date: 20080307. Revision Date: 20161120. Publication Type: journal article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Prostatic Neoplasms -- Drug Therapy
KW  - Prostatic Neoplasms -- Pathology
KW  - Adult
KW  - Aged
KW  - Antineoplastic Agents, Hormonal -- Administration and Dosage
KW  - Clinical Trials
KW  - Disease Progression
KW  - Drug Administration Schedule
KW  - Flutamide -- Administration and Dosage
KW  - Hydrocarbons -- Administration and Dosage
KW  - Leuprolide -- Administration and Dosage
KW  - Male
KW  - Middle Age
KW  - Prostate-Specific Antigen -- Blood
KW  - Prostatic Neoplasms -- Immunology
KW  - Survival Analysis
KW  - Treatment Outcomes
KW  - Human
SP  - 1470
EP  - 1477
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 4
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To assess the efficacy and toxicity of suramin, hydrocortisone, leuprolide, and flutamide in previously untreated metastatic prostate cancer.Patients and Methods: Patients with stage D2 and poor-prognosis stage D1 prostate cancer were given suramin on a pharmacokinetically derived dosing schedule to maintain suramin concentrations between 175 and 300 micrograms/mL. Additionally, all patients received flutamide 250 mg orally three times daily, initiated on day 1 and continued until disease progression; depot leuprolide 7.5 mg intramuscularly begun on day 5 and repeated every 4 weeks indefinitely; and replacement doses of hydrocortisone.Results: Fifty patients were entered onto the study: 48 with stage D2 and two with stage D1 disease. The median age was 59 years (range, 42 to 79) and 31 patients had a Karnofsky performance status (KPS) of 100%. Forty-five patients had bone metastases and 25 had measurable soft tissue disease. Forty-one (82%) had severe disease. The overall response rate in 49 assessable patients was three complete responses (CRs) and 30 partial responses (PRs) for an overall response rate of 67%. Eighteen patients have died. The median survival time has not been reached, with a median potential follow-up duration of 44 months. Grade 3 to 4 toxicity was seen in 38% of patients and was predominantly hematologic and reversible.Conclusion: The high response rate and prolonged survival in a poor-prognosis group of patients with metastatic prostate cancer warrant a phase III randomized comparison of this regimen versus hormonal therapy alone. Toxicity was moderate and reversible.
SN  - 0732-183X
AD  - Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA
U2  - PMID: 9193342.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105822534
T1  - Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9-aminocamptothecin in adult cancer patients.
AU  - Takimoto CH
AU  - Dahut W
AU  - Marino MT
AU  - Nakashima H
AU  - Liang MD
AU  - Harold N
AU  - Lieberman R
AU  - Arbuck SG
AU  - Band RA
AU  - Chen AP
AU  - Hamilton JM
AU  - Cantilena LR
AU  - Allegra CJ
AU  - Grem JL
AU  - Takimoto, C H
AU  - Dahut, W
AU  - Marino, M T
AU  - Nakashima, H
AU  - Liang, M D
AU  - Harold, N
Y1  - 1997/04//
N1  - Accession Number: 105822534. Language: English. Entry Date: 20080307. Revision Date: 20161120. Publication Type: journal article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Alkaloids -- Analogs and Derivatives
KW  - Antineoplastic Agents -- Pharmacodynamics
KW  - Neoplasms -- Blood
KW  - Neoplasms -- Drug Therapy
KW  - Adult
KW  - Aged
KW  - Alkaloids -- Administration and Dosage
KW  - Alkaloids -- Pharmacodynamics
KW  - Alkaloids -- Pharmacokinetics
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Antineoplastic Agents -- Pharmacokinetics
KW  - Chromatography, High Pressure Liquid
KW  - Clinical Trials
KW  - Drug Administration Schedule
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Time
KW  - Human
SP  - 1492
EP  - 1501
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 4
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To investigate the pharmacokinetics and pharmacodynamics of 9-aminocamptothecin (9-AC) infused over 72 hours at doses of 5 to 74 micrograms/m2/h.Patients and Methods: 9-AC lactone and total (lactone plus carboxylate) plasma concentrations were measured in 44 patients with solid tumors using a high-performance liquid chromatography (HPLC) assay. Fifteen patients underwent extended pharmacokinetic sampling to determine the distribution and elimination kinetics of 9-AC.Results: At steady-state, 8.7% +/- 4.7% (mean +/- SD) of the total drug circulated in plasma as the active 9-AC lactone. Clearance of 9-AC lactone was uniform (24.5 +/- 7.3 L/h/m2) over the entire dose range examined; however, total 9-AC clearance was nonlinear and increased at higher dose levels. In 15 patients treated at dose levels > or = 47 micrograms/m2/h, the volume of distribution at steady-state for 9-AC lactone was 195 +/- 114 L/m2 and for total 9-AC it was 23.6 +/- 10.6 L/m2. The elimination half-life was 4.47 +/- 0.53 hours for 9-AC lactone and 8.38 +/- 2.10 hours for total 9-AC. In pharmacodynamic studies, dose-limiting neutropenia correlated with steady-state lactone concentrations (Css) R2 = .77) and drug dose (R2 = .71).Conclusion: Plasma 9-AC concentrations rapidly declined to low levels following the end of a 72-hour infusion and the mean fraction of total 9-AC circulating in plasma as the active lactone was less than 10%. The pharmacokinetics of 9-AC may have a great impact on its clinical activity and should be considered in the design of future clinical trials of this topoisomerase I inhibitor.
SN  - 0732-183X
AD  - National Cancer Institute-Navy Medical Oncology Branch, Division of Clinical Sciences, National Cancer Institute, National Naval Medical Center, Bethesda, MD 20889-5105, USA
U2  - PMID: 9193345.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105822539
T1  - Phase I trial of docetaxel administered as a 1-hour infusion in children with refractory solid tumors: a collaborative pediatric branch, National Cancer Institute and Children's Cancer Group trial.
AU  - Blaney SM
AU  - Seibel NL
AU  - O'Brien M
AU  - Reaman GH
AU  - Berg SL
AU  - Adamson PC
AU  - Poplack DG
AU  - Krailo MD
AU  - Mosher R
AU  - Balis FM
AU  - Blaney, S M
AU  - Seibel, N L
AU  - O'Brien, M
AU  - Reaman, G H
AU  - Berg, S L
AU  - Adamson, P C
AU  - Poplack, D G
AU  - Krailo, M D
AU  - Mosher, R
AU  - Balis, F M
Y1  - 1997/04//
N1  - Accession Number: 105822539. Language: English. Entry Date: 20080307. Revision Date: 20161120. Publication Type: journal article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: 13539//PHS HHS/United States. NLM UID: 8309333. 
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Hydrocarbons
KW  - Neoplasms -- Drug Therapy
KW  - Paclitaxel -- Analogs and Derivatives
KW  - Adolescence
KW  - Adult
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Child
KW  - Child, Preschool
KW  - Clinical Trials
KW  - Drug Administration Schedule
KW  - Female
KW  - Incidence
KW  - Infant
KW  - Infusions, Intravenous
KW  - Male
KW  - Neutropenia -- Chemically Induced
KW  - Paclitaxel -- Administration and Dosage
KW  - Paclitaxel -- Adverse Effects
KW  - Severity of Illness Indices
KW  - Treatment Outcomes
KW  - Human
SP  - 1538
EP  - 1543
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 4
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: A phase I trial of docetaxel was performed to determine the maximum-tolerated dose (MTD), the dose-limiting toxicities, and the incidence and severity of other toxicities in children with refractory solid tumors.Patients and Methods: Forty-four children received 103 courses of docetaxel administered as a 1-hour intravenous infusion every 21 days. Doses ranged from 55 to 150 mg/m2, MTD was defined in heavily pretreated and less heavily pretreated (< or = 2 prior chemotherapy regimens, no prior bone marrow transplantation [BMT], and no radiation to the spine, skull, ribs, or pelvic bones) patients.Results: Dose-related neutropenia was the primary dose-limiting toxicity. The MTD in the heavily pretreated patient group was 65 mg/m2, but the less heavily pretreated patients tolerated a significantly higher dose of docetaxel (maximum-tolerated dose, 125 mg/m2). Neutropenia and constitutional symptoms consisting of malaise, myalgias, and anorexia were the dose-limiting toxicities at 150 mg/m2 in the less heavily pretreated patients. Thrombocytopenia was not prominent, even in patients who experienced dose-limiting neutropenia. Common nonhematologic toxicities of docetaxel included skin rashes, mucositis, and mild elevations of serum transaminases. Neuropathy was uncommon. Peripheral edema and weight gain were observed in two of five patients who received more than three cycles of docetaxel. A complete response (CR) was observed in one patient with rhabdomyosarcoma, a partial response (PR) in one patient with peripheral primitive neuroectodermal tumor (PPNET), and a minimal response (MR) in two patients with PPNET. Three of the four responding patients were treated at doses > or = 100 mg/m2.Conclusion: The recommended phase II dose of docetaxel administered as a 1-hour intravenous infusion in children with solid tumors in 125 mg/m2. Because neutropenia was the dose-limiting toxicity and thrombocytopenia was mild, further escalation of the dose should be attempted with granulocyte colony-stimulating factor (G-CSF) support.
SN  - 0732-183X
AD  - Pediatric Branch, National Cancer Institute, Bethesda, MD, USA
U2  - PMID: 9193350.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Asada, Hideo
AU  - Linton, Jay
AU  - Katz, Stephon I.
T1  - Cytokine Gene Expression during the Elicitation Phase of Contact Sensitivity: Regulation By Endogenous IL-4.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/04//
VL  - 108
IS  - 4
M3  - Article
SP  - 406
EP  - 411
SN  - 0022202X
AB  - Recent studies have focused on characterizing the cytokine profile produced in the epidermis during the sensitization phase of contact sensitivity (CS). Some prior studies have also identified altered individual cytokine mRNA profiles in skin or draining lymph nodes (or several cytokine mRNA profiles in the epidermis) during the elicitation phase of CS. In this study we determined the dynamics of appearance of a battery of cytokine mRNA levels in both the epidermis and dermis during the elicitation phase of Cs. We isolated mRNA from dispase-separated epidermis and dermis of TNCB-sensitized and naïve BALB/c mice at various times after TNCB challenge. Changes in IFN--γ and IL-4 mRNA levels (by semiquantitative RT-PCR) were more reproducible and dramatic than those of other cytokines studied (IL-1β, IL-2, IL-10, and IL-12 p40). Compared to naïve mice, sensitized mice had significantly elevated IL-4 mRNA signals 9 and 24 h (dermis), and 24 h (epidermis), after TNCB challenge. The increased IL-4 mRNA levels were mast-cell-independent, because sensitized mast-cell-deficient mice showed similar increases in IL-4 mRNA. To examine the role of endogenous IL-4 in CS elicitation, sensitized mice were treated with anti-IL-4 mAb I h before challenge. In accord with prior studies, anti-IL-4 mAb-pretreated mice showed increased ear swelling 24 h after challenge compared to mice pretreated with isotype control mAb. AntiIL-4 mAb pretreatment also enhanced IFN-γ, IL-2, IL-12 p40, and IL-1β (but not IL10) mRNA signals in the dermis of sensitized and challenged mice. These data indicate that IL-4 is produced in murine skin during the elicitation phase of CS and is an important down-modulator of inflammation. IL-4 may blunt CS by regulating local production of proinflammatory cytokines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONTACT dermatitis
KW  - CYTOKINES
KW  - EPIDERMIS
KW  - RNA
KW  - DERMIS
KW  - LYMPH nodes
KW  - <em>mRNA</em>
KW  - <em>T-helper cells Th1 and Th2</em>
N1  - Accession Number: 12289700; Asada, Hideo 1 Linton, Jay 1 Katz, Stephon I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Apr97, Vol. 108 Issue 4, p406; Subject Term: CONTACT dermatitis; Subject Term: CYTOKINES; Subject Term: EPIDERMIS; Subject Term: RNA; Subject Term: DERMIS; Subject Term: LYMPH nodes; Author-Supplied Keyword: <em>mRNA</em>; Author-Supplied Keyword: <em>T-helper cells Th1 and Th2</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12289700
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goebeler, Matthias
AU  - Yoshimura, Teizo
AU  - Toksoy, Atiye
AU  - Ritter, Uwe
AU  - Bröcker, Eva-Bettina
AU  - Gillitzer, Reinhard
T1  - The Chemokine Repertoire of Human Dermal Microvascular Endothelial Cells and Its Regulation by Inflammatory Cytokines.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/04//
VL  - 108
IS  - 4
M3  - Article
SP  - 445
EP  - 451
SN  - 0022202X
AB  - Activation of endothelium is a critical event during the initiation of inflammatory processes and is associated with the induction of cell adhesion molecules and cytokines. The latter include chemotactically active cytokines (chemokines) that promote leukocyte diapedesis from the circulation to sites of evolving inflammation. In this study we evaluated the chemokine repertoire of human endotheial cells de- rived from the skin (HDMFCs) and regulation of these chemokines by cytokines. HDMECs and an immortalized human dermal microvascular endothelial cell line, HMEC-1, were investigated for the expression of C-X-C and C-C chemokines at mRNA and protein levels. Upon stimulation with interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), both HDMECs and HMEC-1 expressed high levels of IL-8, GRO, and monocyte chemoattractant protein-1 (MCP-1). RANTES was only weakly induced; however, concomitant treatment with TNF-a and interferon-γ (IFN-γ) led to upregulation of RANTES, indicating a synergy between these two cytokines. The C-X-C chemokine IFN-inducible protein-10 was upregulated by IFN-γ but not by other cytokines studied. Macrophage inflammatory protein-1α and β, I-309, and ENA-78 could not be induced. The chemokine repertoires of HDMECs and HMEC-1 were compared to those of human umbilical vein endothelium and found to be rather similar with the important exception that IFN-γ and IL-4 up-regulated MCP-1 only in macrovascular endothelium. Our data indicate that HDMECs contribute to the dermal cytokine network by selective production of MCP-1, IL-8, GRO, RANTES, and IP-10, which may critically influence the site-specific recruitment of leukocyte subsets. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHEMOKINES
KW  - SKIN
KW  - CYTOKINES
KW  - ENDOTHELIUM
KW  - CELL adhesion
KW  - LEUCOCYTES
KW  - <em>GRO</em>
KW  - <em>interleukin-8</em>
KW  - <em>monocyte chemoattractant protein-1</em>
KW  - <em>RANTES</em>
N1  - Accession Number: 12289711; Goebeler, Matthias 1 Yoshimura, Teizo 2 Toksoy, Atiye 1 Ritter, Uwe 3 Bröcker, Eva-Bettina 1 Gillitzer, Reinhard 1; Affiliation:  1: Department of Dermatology, , University of Würzburg. Würzburg, Germany.  2: Laboratory of Immunobiology, Immunopathology Section, National Cancer Institute, Frederick, Maryland, U.S.A.  3: Infectious Diseases Research Center, University of Würzburg. Würzburg, Germany.; Source Info: Apr97, Vol. 108 Issue 4, p445; Subject Term: CHEMOKINES; Subject Term: SKIN; Subject Term: CYTOKINES; Subject Term: ENDOTHELIUM; Subject Term: CELL adhesion; Subject Term: LEUCOCYTES; Author-Supplied Keyword: <em>GRO</em>; Author-Supplied Keyword: <em>interleukin-8</em>; Author-Supplied Keyword: <em>monocyte chemoattractant protein-1</em>; Author-Supplied Keyword: <em>RANTES</em>; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12289711
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DarIing, Thomas N.
AU  - McGrath, John A.
AU  - Yee, Carole
AU  - Gatalica, Biljana
AU  - Hametner, Rudolf
AU  - Bauer, Johann W.
AU  - Pohla-Gubo, Gabriele
AU  - Christiano, Angela M.
AU  - Uitto, Jouni
AU  - Hintner, Helmut
AU  - Yancey, Kim B.
T1  - Premature Termination Codons Are Present on Both Alleles of the Bullous Pemphigoid Antigen 2/ Type XVII Collagen Gene in Five Austrian Families with Generalized Atrophic Benign Epidermolysis Bullosa.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/04//
VL  - 108
IS  - 4
M3  - Article
SP  - 463
EP  - 468
SN  - 0022202X
AB  - Patients with generalized atrophic benign epidermolysis bullosa (GABEB), an inherited subepidermaI blistering disease, often have no immunologically de- tectable bullous pemphigoid antigen 2 (BPAG2) in theft epidermal basement membrane. Recently, we analyzed the BPAG2 gene (GenBank no. M91669) in an Austrian family with GABEB and identified a homozygous deletion mutation, 4003delTC, that results in a downstream premature termination codon (PTC). This mutation has now been identified in additional descendants, suggesting transmission of this mutant allele through at least six generations. Screening of four other Austrian GABEB families revealed that affected members were homozygous for 4003delTC in two cases and heterozygous in two others. In the latter, mutational analysis identified two novel nonsense mutations, Q1403X and G8O3X, that were confirmed by restriction endonuclease digestions. Thus, PTCs on both alleles of BPAG2 are present in all of these GABEB families. Immunopre- cipitation and northern blot studies of cultured keratinocytes from homozygous GABEB patients show that 4003delTC results in undetectable levels of BPAG2 protein and mRNA-flndings consistent with the process of nonsense-mediated nRNA decay. Incubating keratinocytes with cycloheximide increased BPAG2 mRNA to a level detectable by northern analysis. `When the latter was used in reverse transcription-PCR studies, the mutation was demonstrated, suggesting that cyclohexhnide may allow mutational analysis in cases where low transcript levels have previously thwarted RT-PCR studies. These findings account for the absence of BPAG2 in GABEB patients and attest to the importance of this protein in adhesion of epidermis to epidermal basement membrane. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - COLLAGEN
KW  - ENDONUCLEASES
KW  - KERATINOCYTES
KW  - EPIDERMIS
KW  - ADHESION
KW  - <em>basement membrane</em>
KW  - <em>COL17A1</em>
KW  - <em>hemidesmosomes</em>
KW  - <em>heritable blistering diseases</em>
KW  - <em>mutation</em>
N1  - Accession Number: 12289718; DarIing, Thomas N. 1 McGrath, John A. 2,3 Yee, Carole 1 Gatalica, Biljana 2 Hametner, Rudolf 4 Bauer, Johann W. 4 Pohla-Gubo, Gabriele 4 Christiano, Angela M. 2 Uitto, Jouni 2 Hintner, Helmut 4 Yancey, Kim B. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Departments of Dermatology and Cutaneous Biology, and Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.  3: St. John's Institute of Dermatology (UMDS), St. Thomas's Hospital, London, U.K.  4: Department of Dermatology, General Hospital, Salzburg, Austria.; Source Info: Apr97, Vol. 108 Issue 4, p463; Subject Term: ANTIGENS; Subject Term: COLLAGEN; Subject Term: ENDONUCLEASES; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: ADHESION; Author-Supplied Keyword: <em>basement membrane</em>; Author-Supplied Keyword: <em>COL17A1</em>; Author-Supplied Keyword: <em>hemidesmosomes</em>; Author-Supplied Keyword: <em>heritable blistering diseases</em>; Author-Supplied Keyword: <em>mutation</em>; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12289718
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12289718&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107237343
T1  - Dyspnea: pathophysiology and assessment.
AU  - Ripamonti C
AU  - Bruera E
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 107237343. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Chronic Respiratory Questionnaire (CRQ); Baseline and Transition Dyspnea Index; Borg Scale of Perceived Exertion. NLM UID: 8605836. 
KW  - Dyspnea -- Physiopathology
KW  - Dyspnea -- Diagnosis
KW  - Neoplasms -- Complications
KW  - Visual Analog Scaling
KW  - Clinical Assessment Tools
KW  - Dyspnea -- Etiology
KW  - Respiration
SP  - 220
EP  - 232
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 13
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
AB  - Dyspnea is frequently a multicausal and devastating symptom among advanced cancer patients. It occurs in 21%-78.6% of patients days or weeks before death and is often difficult to control. The genesis and pathophysiology of dyspnea as a symptom still has not been well understood. Dyspnea is frequently associated with abnormalities in the mechanisms that regulate normal breathing; however, the actual expression of dyspnea by a patient results from a complex interaction between the abnormalities in breathing and the perception of those abnormalities in the central nervous system. The production of dyspnea has to be related to the activation of mechanoreceptors both in the respiratory muscles and in the lung, even in the absence of increased muscle respiratory activity. Respiratory muscle weakness appears to be an important cause of dyspnea in malnourished, asthenic, and cachectic cancer patients. This might also explain why about 24% of dyspneic cancer patients do not present cardiac\pulmonary disease. In addition, two other possible mechanisms of dyspnea have been proposed: chemoreceptor stimulation and efferent activity from the respiratory center by direct ascending stimulation. These factors and the assessment tools used in patients with chronic dyspnea are summarized in this review. (C) U.S. Cancer Pain Relief Committee, 1997 Published by Elsevier, New York, New York
SN  - 0885-3924
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute, via Venezian 1, 20133 Milan, Italy
U2  - PMID: 9136233.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107237343&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104794174
T1  - An update on the clinical use of methadone for cancer pain.
AU  - Ripamonti, C
AU  - Zecca, E
AU  - Bruera, E
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 104794174. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Analgesics, Opioid -- Therapeutic Use
KW  - Methadone -- Therapeutic Use
KW  - Neoplasms -- Drug Therapy
KW  - Palliative Care -- Trends
KW  - Administration, Oral
KW  - Administration, Rectal
KW  - Analgesics, Opioid -- Administration and Dosage
KW  - Analgesics, Opioid -- Adverse Effects
KW  - Evaluation Research
KW  - Human
KW  - Methadone -- Administration and Dosage
KW  - Methadone -- Adverse Effects
SP  - 109
EP  - 115
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 70
IS  - 2-3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Milano, Italy.
U2  - PMID: 9150283.
DO  - 10.1016/S0304-3959(96)03286-1
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104794174&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104794176
T1  - Antinociceptive effects of dynorphin peptides in a model of inflammatory pain.
AU  - Beyer, A
AU  - Schäfer, M
AU  - Stein, C
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 104794176. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Analgesics, Opioid -- Therapeutic Use
KW  - Foot
KW  - Inflammation -- Physiopathology
KW  - Nociceptors -- Drug Effects
KW  - Opioid Peptides -- Therapeutic Use
KW  - Peptides -- Therapeutic Use
KW  - Analgesics -- Therapeutic Use
KW  - Analgesics, Opioid -- Adverse Effects
KW  - Animal Studies
KW  - Edema -- Chemically Induced
KW  - Enkephalins
KW  - Enkephalins -- Therapeutic Use
KW  - Male
KW  - Opioid Peptides -- Adverse Effects
KW  - Peptides -- Adverse Effects
KW  - Rats
SP  - 141
EP  - 147
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 70
IS  - 2-3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Division of Intramural Research, National Institute on Drug Abuse, Baltimore, MD 21224, USA.
U2  - PMID: 9150287.
DO  - 10.1016/S0304-3959(97)03327-7
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104794176&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104794184
T1  - Blockade of peripheral neuronal barrage reduces postoperative pain.
AU  - Gordon, S M
AU  - Dionne, R A
AU  - Brahim, J
AU  - Jabir, F
AU  - Dubner, R
Y1  - 1997/04//1997 Apr
N1  - Accession Number: 104794184. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Anesthetics, Local -- Therapeutic Use
KW  - Bupivacaine -- Therapeutic Use
KW  - Nerve Block
KW  - Neurons, Afferent
KW  - Postoperative Pain -- Drug Therapy
KW  - Peripheral Nerves
KW  - Adult
KW  - Analgesics, Opioid -- Administration and Dosage
KW  - Analgesics, Opioid -- Therapeutic Use
KW  - Codeine -- Administration and Dosage
KW  - Codeine -- Therapeutic Use
KW  - Double-Blind Studies
KW  - Female
KW  - Human
KW  - Male
KW  - Molar, Third -- Surgery
KW  - Pain -- Physiopathology
KW  - Postoperative Pain -- Blood
KW  - Postoperative Pain -- Pathology
KW  - Self Administration
KW  - Tooth, Impacted -- Blood
KW  - Tooth, Impacted -- Surgery
KW  - Endorphins -- Blood
SP  - 209
EP  - 215
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 70
IS  - 2-3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 9150295.
DO  - 10.1016/S0304-3959(96)03315-5
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104794184&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-40011-033
AN  - 2015-40011-033
AU  - Svingos, Adena L.
AU  - Moriwaki, Akiyoshi
AU  - Wang, Jia Bei
AU  - Uhl, George R.
AU  - Pickel, Virginia M.
T1  - μ-opioid receptors are localized to extrasynaptic plasma membranes of GABAergic neurons and their targets in the rat nucleus accumbens.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/04//
VL  - 17
IS  - 7
SP  - 2585
EP  - 2594
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Svingos, Adena L., Department of Neurology and Neuroscience, Division of Neurobiology, Cornell University Medical College, 411 East 69th Street, New YorK, NY, US, 10021
N1  - Accession Number: 2015-40011-033. PMID: 9065518 Partial author list: First Author & Affiliation: Svingos, Adena L.; Division of Neurobiology, Department of Neurology and Neuroscience, Cornell University Medical Center, New YorK, NY, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Svingos, Adena L. Major Descriptor: Gamma Aminobutyric Acid; Neurons; Nucleus Accumbens; Opiates; Synapses. Minor Descriptor: Rats; Cell Membrane. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Apr, 1997. Publication History: Accepted Date: Jan 16, 1997; Revised Date: Jan 14, 1997; First Submitted Date: Dec 9, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The activation of μ-opioid receptors in the nucleus accumbens (Acb) produces changes in locomotor and rewarding responses that are believed to involve neurons, including local γ-aminobutyric acid (GABA)ergic neurons. We combined immunogold–silver detection of an antipeptide antiserum against the cloned μ-opioid receptor (MOR) and immunoperoxidase labeling of an antibody against GABA to determine the cellular basis for the proposed opioid modulation of GABAergic neurons in the rat Acb. MOR-like immunoreactivity (MOR-LI) was localized prominently to plasma membranes of neurons having morphological features of both spiny and aspiny cells, many of which contained GABA. Of 351 examples of profiles that contained MOR-LI and GABA labeling, 65% were dendrites. In these dendrites, MOR-LI was seen mainly along extrasynaptic portions of the plasma membrane apposed to unlabeled terminals and/or glial processes. Dually labeled dendrites often received convergent input from GABAergic terminals and/or from unlabeled terminals forming asymmetric excitatory-type synapses. Of all profiles that contained both MOR and GABA immunoreactivity, 28% were axon terminals. MOR-containing GABAergic terminals and terminals separately labeled for MOR or GABA formed synapses with unlabeled dendrites and also with dendrites containing MOR or GABA. Our results indicate that MOR agonists could modulate the activity of GABA neurons in the Acb via receptors located mainly at extrasynaptic sites on dendritic plasma membranes. MOR ligands also could alter the release of GABA onto target dendrites that contain GABA and/or respond to opiate stimulation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - g-aminobutyric acid
KW  - striatum
KW  - enkephalin
KW  - opiate
KW  - ultrastructure
KW  - electron microscopy
KW  - morphine
KW  - 1997
KW  - Gamma Aminobutyric Acid
KW  - Neurons
KW  - Nucleus Accumbens
KW  - Opiates
KW  - Synapses
KW  - Rats
KW  - Cell Membrane
KW  - 1997
U1  - Sponsor: Aaron Diamond Foundation. Other Details: Postdoctoral Fellowship. Recipients: Svingos, Adena L.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: DA04600. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, Intramural Research Group, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40011-033&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40020-003
AN  - 2015-40020-003
AU  - Knutson, Peter
AU  - Ghiani, Cristina A.
AU  - Zhou, Jia-Min
AU  - Gallo, Vittorio
AU  - McBain, Chris J.
T1  - K+ channel expression and cell proliferation are regulated by intracellular sodium and membrane depolarization in oligodendrocyte progenitor cells.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/04//
VL  - 17
IS  - 8
SP  - 2669
EP  - 2682
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - McBain, Chris J., Laboratory of Cellular and Molecular Neurophysiology, NICHD, National Institutes of Health, Room 5A72, Building 49, 49 Convent Drive, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-40020-003. PMID: 9092588 Partial author list: First Author & Affiliation: Knutson, Peter; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Knutson, Peter. Major Descriptor: Potassium Ions; Depolarization; Hyperpolarization; Cell Proliferation; Progenitor Cells. Minor Descriptor: Sodium; Oligodendrocytes. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Apr, 1997. Publication History: Accepted Date: Jan 30, 1997; Revised Date: Jan 28, 1997; First Submitted Date: Dec 23, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The effects of a variety of antiproliferative agents on voltagedependent K+ channel function in cortical oligodendrocyte progenitor (O-2A) cells were studied. Previously, we had shown that glutamate receptor activation reversibly inhibited O-2A cell proliferation stimulated by mitogenic factors and prevented lineage progression by attenuating outward K+ currents in O-2A cells. We now show that the antiproliferative actions of glutamate receptor activation are Ca2+-independent and arise from an increase in intracellular Na1 and subsequent block of outward K+ currents. In support of this mechanism, agents that acted to depolarize O-2A cells or increase intracellular sodium similarly had an antiproliferative effect, attributable at least in part to a reduction in voltage-gated K+ currents. Also, these effects were reversible and Ca2+-independent. Chronic treatment with glutamate agonists was without any long-term effect on K+ current function. Cells cultured in elevated K+, however, demonstrated an upregulation of inward rectifier K+ currents, concomitant with an hyperpolarization of the resting membrane potential. This culture condition therefore promoted a current phenotype typical of pro-oligodendroblasts. Finally, cells chronically treated with the mitotic inhibitor retinoic acid displayed a selective downregulation of outward K+ currents. In conclusion, signals that affect O-2A cell proliferation do so by regulating K+ channel function. These data indicate that the regulation of K+ currents in cells of the oligodendrocyte lineage plays an important role in determining their proliferative potential and demonstrate that O-2A cell K+ current phenotype can be modified by long-term depolarization of the cell membrane. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cell proliferation
KW  - oligodendrocyte progenitor
KW  - glutamate receptor activation
KW  - cortical oligodendrocyte progenitor
KW  - 1997
KW  - Potassium Ions
KW  - Depolarization
KW  - Hyperpolarization
KW  - Cell Proliferation
KW  - Progenitor Cells
KW  - Sodium
KW  - Oligodendrocytes
KW  - 1997
U1  - Sponsor: National Institute of Child Health and Human Development, US. Other Details: Pre-IRTA Fellowship. Recipients: Knutson, Peter
U1  - Sponsor: National Research Council of Italy, Italy. Other Details: Fellowship. Recipients: Ghiani, Cristina A.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40020-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40020-020
AN  - 2015-40020-020
AU  - Duffy, Charles J.
AU  - Wurtz, Robert H.
T1  - Medial superior temporal area neurons respond to speed patterns in optic flow.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/04//
VL  - 17
IS  - 8
SP  - 2839
EP  - 2851
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Duffy, Charles J., Department of Neurology, University of Rochester Medical Center, Box 673, 601 Elmwood Avenue, Rochester, NY, US, 14642-0673
N1  - Accession Number: 2015-40020-020. PMID: 9092605 Partial author list: First Author & Affiliation: Duffy, Charles J.; Department of Neurology, University of Rochester Medical Center, Rochester, NY, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Duffy, Charles J. Major Descriptor: Motion Perception; Neurons; Visual Perception. Minor Descriptor: Cues. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Apr, 1997. Publication History: Accepted Date: Jan 28, 1997; Revised Date: Jan 17, 1997; First Submitted Date: Nov 12, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The speed of visual motion in optic flow fields can provide important cues about self-movement. We have studied the speed sensitivities of 131 neurons in the dorsal region of the medial superior temporal area (MSTd) that responded to either radial or circular optic flow stimuli. The responses of more than two-thirds of these neurons were strongly modulated by changes in the mean speed of motion in optic flow stimuli, with response profiles resembling simple filter characteristics. When we removed the normal gradient of speeds in optic flow (slower speeds in the center, faster speeds in the periphery), approximately two-thirds of the neurons showed changes in their responses. When the speed gradient was altered rather than eliminated, almost nine in 10 neurons preferred either a normal speed gradient or an inverted one (slower speeds near the periphery) over stimuli with no speed gradient. These speed gradient preferences do not come simply from different speed preferences in the central and peripheral segments of the stimulus area. Rather, these speed gradient preferences seemed to reflect interactions between simultaneously presented speeds within an optic flow stimulus. The sensitivity of MSTd neurons to patterns of speed, as well as patterns of direction, strengthens the view that these neurons are well suited to the analysis of optic flow. Sensitivity to speed gradients in optic flow might contribute to neuronal mechanisms for spatial orientation during self-movement and for representing the three-dimensional structure of the visual environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - optic flow
KW  - motion
KW  - speed
KW  - vision
KW  - extrastriate
KW  - MST
KW  - 1997
KW  - Motion Perception
KW  - Neurons
KW  - Visual Perception
KW  - Cues
KW  - 1997
U1  - Sponsor: National Eye Institute, US. Grant: R01-EY10287. Recipients: Duffy, Charles J.
U1  - Sponsor: Sloan Foundation. Recipients: Duffy, Charles J.
U1  - Sponsor: Research to Prevent Blindness. Other Details: University of Rochester Department of Ophthalmology. Recipients: Duffy, Charles J.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40020-020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107330530
T1  - Register of dietary assessment calibration-validation studies: a status report... proceedings of a symposium held in Boston, MA, January 22-24, 1995.
AU  - Thompson FE
AU  - Moler JE
AU  - Freedman LS
AU  - Clifford CK
AU  - Stables GJ
AU  - Willett WC
Y1  - 1997/04/02/Apr97 Supplement
N1  - Accession Number: 107330530. Language: English. Entry Date: 19970701. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Supplement Title: Apr97 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Diet -- Evaluation
KW  - Nutritional Assessment
KW  - Resource Databases
KW  - Validation Studies
KW  - Diet Records
KW  - Questionnaires
KW  - Research
KW  - Research Instruments
KW  - Self Report
KW  - Validity
SP  - 1142S
EP  - 7S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 65
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - A register of dietary assessment calibration-validation studies was created to improve communication between investigators, avoid duplication of effort, and identify gaps in knowledge. Calibration-validation studies were defined as investigations in which the participants completed at least two different dietary measurements. A questionnaire soliciting descriptive information about such studies was widely distributed. Completed questionnaires were received from October 1993 through September 1994 and the data from them were entered into a computer database. Preliminary individual reports were mailed to all contributors in September 1994 for revision or updating. Responses received by the end of October 1994 were incorporated into the database. A status report was published in December 1994. The report includes descriptions of 84 studies, 15 summary tables, and 6 reference indexes. Of the 84 studies included, 44 (52%) were conducted in North America, 35 (42%) in Europe, 2 (2%) in South America, 2 (2%) in Asia, and 1 (1%) in Australia. Sixty-three of the 84 studies (75%) used food-frequency questionnaires, 52 (62%) used food records, 35 (42%) used one or more dietary recalls, 11 (13%) used biological measures, and 8 (10%) used diet histories. Plans for maintaining and updating the register are being developed. (C) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD
U2  - PMID: 9094911.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107330530&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107330568
T1  - Characterizing food intake patterns of American adults... proceedings of a symposium held in Boston, MA, January 22-24, 1995.
AU  - Krebs-Smith SM
AU  - Cleveland LE
AU  - Ballard-Barbash R
AU  - Cook DA
AU  - Kahle LL
Y1  - 1997/04/02/Apr97 Supplement
N1  - Accession Number: 107330568. Language: English. Entry Date: 19970701. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Supplement Title: Apr97 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Diet -- Evaluation -- In Adulthood
KW  - Food Habits -- In Adulthood -- United States
KW  - Adult
KW  - Data Analysis Software
KW  - Diet Records
KW  - Energy Intake
KW  - Human
KW  - Interviews
KW  - Macronutrients
KW  - Micronutrients
KW  - Nutritional Assessment
KW  - Nutritional Requirements
KW  - Sampling Methods
KW  - Surveys
KW  - United States
SP  - 1264S
EP  - 8S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 65
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Food-pattern analysis provides a way to examine diets in a multidimensional context. This study examined the diets of 8181 adults in the 1989-1991 Continuing Survey of Food Intakes by Individuals and evaluated whether they met the federal recommendations for each of five food groups. The sample was partitioned among 32 different food-intake patterns, six of which represented 44% of the population. Nutrient profiles associated with each of the patterns indicated that failure to meet one or more of the food-group recommendations was associated with nutrient inadequacy, macronutrient imbalance, or both. A reexamination of the data to account for low energy reporters did not alter these findings. The pattern of meeting all five of the food-group recommendations was among the least common, accounting for only 1% of adults' intakes. (C) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Cancer Institute, Bethesda, MD. E-mail: sk52r@nih.gov
U2  - PMID: 9094931.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107330568&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105823389
T1  - Pharmacokinetic problems in peritoneal drug administration: tissue penetration and surface exposure.
AU  - Dedrick RL
AU  - Flessner MF
Y1  - 1997/04/02/
N1  - Accession Number: 105823389. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Antineoplastic Agents -- Pharmacokinetics
KW  - Chemotherapy, Cancer -- Methods
KW  - Peritoneum
KW  - Animals
SP  - 480
EP  - 487
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 7
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 9086004.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Dong-Yan JIN
AU  - Kuan-teh JEANG
T1  - TRANSCRIPTIONAL ACTIVATION AND SELF-ASSOCIATION IN YEAST: PROTEIN-PROTEIN DIMERIZATION AS A PLEIOTROPIC MECHANISM OF HTLV-I TAX FUNCTION.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 3
EP  - 6
PB  - Nature Publishing Group
SN  - 08876924
AB  - The yeast one-hybrid and two-hybrid systems for the detection of protein-DNA and protein-protein interactions were used as an in vivo approach to investigate the functional characteristics of HTLV-I Tax expressed in yeast. Tax, when targeted to the upstream activating sequence (UAS) via the DNA-binding domain of Gal4 (GaI4BD), was found to activate a minimal promoter in yeast, indicating the presence of a functionally intact activation domain. Using the two-hybrid assay in which Tax was fused to either GaI4BD or Gal4 activation domain (Gal4AD), we demonstrate that Tax self-associates in the nucleus of yeast cells. Mutational analysis was performed to delineate the functional domain(s) necessary for Tax-mediated trans-activation and self-association. Based on our results, we propose a pleiotropic mechanism in which Tax facilitates protein-protein dimerization of various cellular partners. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HTLV-I (Virus)
KW  - DNA-protein interactions
KW  - PROTEIN-protein interactions
KW  - DNA-binding proteins
KW  - YEAST
N1  - Accession Number: 34696076; Dong-Yan JIN 1 Kuan-teh JEANG 1; Email Address: kjeang@d4.niaid.pc.niaid.nih.gov; Affiliation:  1: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA; Source Info: Apr97 Supplement  3, Vol. 11, p3; Subject Term: HTLV-I (Virus); Subject Term: DNA-protein interactions; Subject Term: PROTEIN-protein interactions; Subject Term: DNA-binding proteins; Subject Term: YEAST; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - JACOBSON, Steven
AU  - KRICHAVSKY, Mark
AU  - FLERLAGE, Nicholas
AU  - LEVIN, Michael
T1  - IMMUNOPATHOGENESIS OF HTLV-I ASSOCIATED NEUROLOGIC DISEASE: MASSIVE LATENT HTLV-I INFECTION IN BONE MARROW OF HAM/TSP PATIENTS.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 73
EP  - 75
PB  - Nature Publishing Group
SN  - 08876924
AB  - The localization of mammalian retroviruses to specified immune organs has significant implications on the pathophysiology of retroviral associated diseases. Human T-cell Lymphntropic Virus Type I (HTLV-I) is considered a CD4+ lymphotropic virus although the virus has been shown to infect a large variety of cells in vitro. Similarly, the human immunodeficiency virus (HIV), once thought to be harbored only in CD4+ peripheral blood lymphocytes (PBL) has been shown to be present in latent form in lymph nodes of HIV infected patients. HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a chronic progressive neurologic disorder of the central nervous system and is believed to result from infection of HTLV-I in association with an immunopathogenic or autoimmune mechanism. Here we describe experiments which utilize the in situ hybridization/polymerase chain reaction technology to demonstrate extensive HTLV-I infection of bone marrow in HAM/TSP patients. We discuss these results in the context of HTLV-I associated neurologic disease and extend these observations to other disorders of potential retroviral etiology and autoimmune involvement. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HTLV-I (Virus)
KW  - NERVOUS system -- Diseases
KW  - BONE marrow
KW  - HIV (Viruses)
KW  - LYMPHOCYTES
KW  - AUTOIMMUNE diseases
KW  - POLYMERASE chain reaction
KW  - RETROVIRUS diseases
N1  - Accession Number: 34696100; JACOBSON, Steven 1 KRICHAVSKY, Mark 1 FLERLAGE, Nicholas 1 LEVIN, Michael 1; Affiliation:  1: Viral Immunology Section, National Institutes of Health, Building 10, Room 5B-16, Bethesda, MD 20892, USA; Source Info: Apr97 Supplement  3, Vol. 11, p73; Subject Term: HTLV-I (Virus); Subject Term: NERVOUS system -- Diseases; Subject Term: BONE marrow; Subject Term: HIV (Viruses); Subject Term: LYMPHOCYTES; Subject Term: AUTOIMMUNE diseases; Subject Term: POLYMERASE chain reaction; Subject Term: RETROVIRUS diseases; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - HARTLEY, Janet W.
AU  - CHATTOPADHYAY, Sisir K.
AU  - MORSE III, Herbert C.
AU  - FREDRICKSON, Torgny N.
T1  - Charlotte Friend Memorial Lecture: Murine leukemia virus (MuLV) tumorigenesis.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 147
EP  - 148
PB  - Nature Publishing Group
SN  - 08876924
AB  - Recent analysis of over 500 lymphomas occurring in NFS.V mice, congenic for Akv-type ecotropic MuLV structural genes, has revealed that about 90% are of B cell lineage as determined by demonstration of clonal rearrangements of Ig heavy chain genes, phenotyping by immunocytochemistry or cytofluorometric analysis, and by site and morphology of tumor. At least 40% of the B cell lymphomas were found to have their origin in the splenic marginal zone, a site only once before described for mouse lymphomas. Clonal somatic integrations of ecotropic MuLV occurred in 85% of tumors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOMAS
KW  - B cells
KW  - MOUSE leukemia complex
KW  - CELL lines
KW  - SPLEEN
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 34696122; HARTLEY, Janet W. 1 CHATTOPADHYAY, Sisir K. 1 MORSE III, Herbert C. 1 FREDRICKSON, Torgny N. 1,2; Affiliation:  1: Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, Bethesda, Maryland, USA  2: Registry of Experimental Cancers, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Apr97 Supplement  3, Vol. 11, p147; Subject Term: LYMPHOMAS; Subject Term: B cells; Subject Term: MOUSE leukemia complex; Subject Term: CELL lines; Subject Term: SPLEEN; Subject Term: IMMUNOGLOBULINS; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MASUDA, Michiaki
AU  - MASUDA, Mari
AU  - RUSCETTI, Sandra K.
AU  - HOFFMAN, Paul M.
T1  - Molecular mechanism for retroviral neuropathogenesis: possible involvement of capillary endothelial cells.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 233
EP  - 235
PB  - Nature Publishing Group
SN  - 08876924
AB  - A neuropathogenic variant of Friend MuLV, PVC-211, causes rapidly progressive spongiform neurodegeneration in susceptible rats and mice. Major targets of PVC-211 MuLV infection are brain capillary endothelial cells (BCEC), suggesting that virus-infected BCEC may play crucial roles in neurological disease induction. Consistent with this possibility, studies using chimeric viruses constructed between PVC-211 MuLV and non-neuropathogenic Friend MuLV have revealed that the BCEC tropism of the virus correlates with its neuropathogenicity. Possible involvement of cytokine expression by PVC-211 MuLV-infected BCEC in the induction of neuropathological changes will be discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLS
KW  - CAPILLARIES
KW  - NEURODEGENERATION
KW  - RATS as laboratory animals
KW  - NERVOUS system -- Diseases
KW  - CYTOKINES
N1  - Accession Number: 34696149; MASUDA, Michiaki 1 MASUDA, Mari 1 RUSCETTI, Sandra K. 1 HOFFMAN, Paul M. 2,3; Affiliation:  1: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland, 21702  2: Research Service, VA Medical Center, Baltimore, Maryland 21201  3: University of Maryland, Baltimore, Maryland 21201; Source Info: Apr97 Supplement  3, Vol. 11, p233; Subject Term: CELLS; Subject Term: CAPILLARIES; Subject Term: NEURODEGENERATION; Subject Term: RATS as laboratory animals; Subject Term: NERVOUS system -- Diseases; Subject Term: CYTOKINES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - BIES, Juraj
AU  - KOLLER, Richard
AU  - HOFFMAN, Barbara
AU  - AMANULLAH, Arshad
AU  - MOCK, Beverly
AU  - WOLFF, Linda
T1  - MuLV-insertional mutagenesis of c-myb and Mml1 in a murine model for promonocytic leukemia.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 247
EP  - 250
PB  - Nature Publishing Group
SN  - 08876924
AB  - Analysis of retroviral integration sites in MuLV-induced promonocytic leukemias has determined that two genetic loci, c-myb and Mml1, can contribute to disease development but not in the same leukemia. Recent studies aimed at understanding the function of Myb in leukemia development have focused on the consequences of ectopic Myb expression on monocytic and granulocytic differentiation in vitro. In all instances Myb was shown to block growth arrest but not commitment to differentiation, a result which is consistent with observed effects of Myb in leukemia development. No effect of Myb protein truncation was observed in these studies although similar truncations are produced as a result of insertional mutagenesis. Common integration site, Mml1, was recently identified and mapped to mouse chromosome 10 within 1cM of c-myb. Despite its linkage to c-myb, Myb mRNA and protein expression appear to be unaffected in leukemias with Mml1 integrations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MUTAGENESIS
KW  - RETROVIRUSES -- Genetics
KW  - MOUSE leukemia viruses
KW  - MONOCYTIC leukemia
KW  - PROTO-oncogenes
KW  - CHROMOSOMES
KW  - GENE expression
KW  - MESSENGER RNA
N1  - Accession Number: 34696154; BIES, Juraj 1 KOLLER, Richard 1 HOFFMAN, Barbara 2 AMANULLAH, Arshad 2 MOCK, Beverly 1 WOLFF, Linda 1; Affiliation:  1: Laboratory of Genetics, National Cancer Institute, Bethesda, MD. 20892-4255  2: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140; Source Info: Apr97 Supplement  3, Vol. 11, p247; Subject Term: MUTAGENESIS; Subject Term: RETROVIRUSES -- Genetics; Subject Term: MOUSE leukemia viruses; Subject Term: MONOCYTIC leukemia; Subject Term: PROTO-oncogenes; Subject Term: CHROMOSOMES; Subject Term: GENE expression; Subject Term: MESSENGER RNA; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - OHASHI, Takashi
AU  - MASUDA, Michiaki
AU  - RUSCETTI, Sandra K.
T1  - Constitutive activation of Stat-related DNA-binding proteins in erythroid cells by the Friend spleen focus-forming virus.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 251
EP  - 254
PB  - Nature Publishing Group
SN  - 08876924
AB  - The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope glycoprotein which allows erythroid cells to proliferate and differentiate in the absence of the erythroid hormone erythropoietin (Epo). In an attempt to understand how the virus alters the growth of erythroid cells, studies were carried out to determine if virus infection leads to the constitutive activation of the Jak-Stat pathway, one of the signal transduction pathways activated by Epo. Our data indicates that expression of SFFV in erythroid cells leads to the constitutive activation of the same Stat proteins that are transiently activated by Epo. While constitutive activation of Star proteins by SFFV is associated with Epo-independent proliferation of splenic erythroid progenitor cells from Fv-2-sensitive mice and Epo-dependent HCD-57 cells, it is not sufficient to induce their differentiation. Although constitutive activation of the same Stat proteins is detected in erythroid cells from SFFV-infected Fv-2-resistant mice, it does not lead to their Epo-independent growth. It is also not required for transformation of erythroid cells by SFFV. Studies are in progress to identify the mechanism by which Stat proteins are phosphorylated in SFFV-infected cells in the absence of Epo. Although it has been shown that Epo activates Star proteins through Jak2 kinase, our results suggest that the SFFV-induced Stat protein activation is Jak2-independent. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA-binding proteins
KW  - ERYTHROCYTE membranes
KW  - VIRUSES
KW  - SPLEEN
KW  - LEUKEMIA
KW  - MICE as laboratory animals
KW  - ERYTHROPOIETIN
KW  - GENETIC aspects
N1  - Accession Number: 34696155; OHASHI, Takashi 1 MASUDA, Michiaki 1 RUSCETTI, Sandra K. 1; Affiliation:  1: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, MD 21702-1201.; Source Info: Apr97 Supplement  3, Vol. 11, p251; Subject Term: DNA-binding proteins; Subject Term: ERYTHROCYTE membranes; Subject Term: VIRUSES; Subject Term: SPLEEN; Subject Term: LEUKEMIA; Subject Term: MICE as laboratory animals; Subject Term: ERYTHROPOIETIN; Subject Term: GENETIC aspects; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Papas, Takis S.
AU  - Bhat, Narayan K.
AU  - Spyropoulos, Demetri D.
AU  - Mjaatvedt, Anne E.
AU  - Vournakis, John
AU  - Seth, Arun
AU  - Watson, Dennis K.
T1  - Functional Relationships Among ETS Gene Family Members.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1997/04/03/Apr97 Supplement  3
VL  - 11
M3  - Article
SP  - 557
EP  - 566
PB  - Nature Publishing Group
SN  - 08876924
AB  - The article discusses the functional relationships among ETS gene family members. The domain of 85 amino acids shared by the family members are commonly localized at the carboxy-terminal end of the protein which is the deoxyribonucleic acid (DNA) binding domain. Precise DNA-protein interactions within the promoter provides the first level of control in the functioning of the ETS genes. Also noted is the role of the members in oncogenesis, tumor suppression and aberrant development.
KW  - GENES
KW  - AMINO acids
KW  - DNA
KW  - PROTEIN binding
KW  - DNA-protein interactions
KW  - PROMOTERS (Genetics)
KW  - CARCINOGENESIS
KW  - ANTIONCOGENES
N1  - Accession Number: 34696254; Papas, Takis S. 1 Bhat, Narayan K. 2 Spyropoulos, Demetri D. 1 Mjaatvedt, Anne E. 1 Vournakis, John 1 Seth, Arun 3 Watson, Dennis K. 1; Affiliation:  1: Center for Molecular and Structural Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC  2: SAIC, Inc., National Cancer Institute, Frederick, MD  3: MRC Group, University of Toronto and Women's College Hospital, Toronto, Canada; Source Info: Apr97 Supplement  3, Vol. 11, p557; Subject Term: GENES; Subject Term: AMINO acids; Subject Term: DNA; Subject Term: PROTEIN binding; Subject Term: DNA-protein interactions; Subject Term: PROMOTERS (Genetics); Subject Term: CARCINOGENESIS; Subject Term: ANTIONCOGENES; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cutler Jr., Richard E.
AU  - Morrison, Deborah K.
T1  - Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/04/15/
VL  - 16
IS  - 8
M3  - Article
SP  - 1953
EP  - 1960
SN  - 02614189
AB  - An interaction with the Ras proto-oncogene product is a requirement for Raf-1 activation in many signaling cascades. The significance of this interaction is demonstrated by the fact that a mutation preventing the Ras–Raf interaction severely impairs the function of both mammalian (Raf-1) and Drosophila (D-Raf) Raf proteins. In D-Raf, however, dominant intragenic mutations have been identified that suppress the effect of the Ras-binding site (RBS) mutation. To address the mechanism by which these mutations restore Raf signaling, we have introduced the suppressor mutations into the analogous residues of mammalian Raf-1. Here, we show that rather than compensating for the RBS mutation by restoring the Ras–Raf-1 interaction, the suppressor mutations increase the enzymatic and biological activity of Raf-1, allowing Raf-1 to signal in the absence of Ras binding. Surprisingly, we find that while one of the suppressor mutations (P181L) increases the basal kinase activity of Raf-1, it also abolishes the ability of wild-type Raf-1 to become activated by Ras. This mutation occurs in the cysteine-rich domain (CRD) of Raf-1 and demonstrates the importance of this region for a productive Ras–Raf interaction. Finally, we present evidence that the most activating suppressor mutation (G498S) increases Raf-1 activity by introducing a novel phosphorylation site into the L12 activation loop of the Raf-1 kinase domain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - MUTATION (Biology)
KW  - DROSOPHILA
KW  - PHOSPHORYLATION
KW  - BINDING sites (Biochemistry)
KW  - activation
KW  - mutation
KW  - Raf-1
KW  - Ras
KW  - signaling
N1  - Accession Number: 21785579; Cutler Jr., Richard E. 1 Morrison, Deborah K. 1; Affiliation:  1: Molecular Basis of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA; Source Info: 4/15/1997, Vol. 16 Issue 8, p1953; Subject Term: PROTEINS; Subject Term: MUTATION (Biology); Subject Term: DROSOPHILA; Subject Term: PHOSPHORYLATION; Subject Term: BINDING sites (Biochemistry); Author-Supplied Keyword: activation; Author-Supplied Keyword: mutation; Author-Supplied Keyword: Raf-1; Author-Supplied Keyword: Ras; Author-Supplied Keyword: signaling; Number of Pages: 8p; Illustrations: 7 Graphs; Document Type: Article
L3  - 10.1093/emboj/16.8.1953
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ura, Kiyoe
AU  - Kurumizaka, Hitoshi
AU  - Dimitrov, Stefan
AU  - Almouzni, Geneviève
AU  - Wolffe, Alan P.
T1  - Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/04/15/
VL  - 16
IS  - 8
M3  - Article
SP  - 2096
EP  - 2107
SN  - 02614189
AB  - We demonstrate using a dinucleosome template that acetylation of the core histones enhances transcription by RNA polymerase III. This effect is not dependent on an increased mobility of the core histone octamer with respect to DNA sequence. When linker histone is subsequently bound, we find both a reduction in nucleosome mobility and a repression of transcription. These effects of linker histone binding are independent of core histone acetylation, indicating that core histone acetylation does not prevent linker histone binding and the concomitant transcriptional repression. These studies are complemented by the use of a Xenopus egg extract competent both for chromatin assembly on replicating DNA and for RNA polymerase III transcription. Incorporation of acetylated histones and lack of linker histones together facilitate transcription by >10-fold in this system; however, they have little independent effect on transcription. Thus core histone acetylation significantly facilitates transcription, but this effect is inhibited by the assembly of linker histones into chromatin. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTONES
KW  - ACETYLATION
KW  - GENETIC transcription
KW  - NUCLEOTIDE sequence
KW  - XENOPUS
KW  - acetylation
KW  - histone
KW  - nucleosome mobility
KW  - nucleosome positioning
KW  - transactional regulation
N1  - Accession Number: 21785566; Ura, Kiyoe 1 Kurumizaka, Hitoshi 2 Dimitrov, Stefan 3 Almouzni, Geneviève 4 Wolffe, Alan P. 2; Email Address: awlme@helix.nih.gov; Affiliation:  1: Department of Virology, Kurume University School of Medicine, 67 Ashahimachi, Kurume, Fukuoka 830, Japan  2: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, USA  3: Laboratoire d'Etudes de la Différentiation et de l'Adherence cellulaire, UMR 5538, CNRS, Institut Albert Bonniot, Domaine de la Merci, 38706 La Tronche Cedex, France  4: Institut Curie, Section de Biologie, 26 rue d'Ulm, 75231 Paris Cedex, France; Source Info: 4/15/1997, Vol. 16 Issue 8, p2096; Subject Term: HISTONES; Subject Term: ACETYLATION; Subject Term: GENETIC transcription; Subject Term: NUCLEOTIDE sequence; Subject Term: XENOPUS; Author-Supplied Keyword: acetylation; Author-Supplied Keyword: histone; Author-Supplied Keyword: nucleosome mobility; Author-Supplied Keyword: nucleosome positioning; Author-Supplied Keyword: transactional regulation; Number of Pages: 12p; Illustrations: 6 Graphs; Document Type: Article
L3  - 10.1093/emboj/16.8.2096
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Galperin, Michael Y.
AU  - Koonin, Eugene V.
T1  - MicroCorrespondence.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997/04/15/
VL  - 24
IS  - 2
M3  - Letter
SP  - 443
EP  - 445
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - A letter to the editor about the sequence analysis of an exceptionally conserved operon is presented.
KW  - Letters to the editor
KW  - Operons
N1  - Accession Number: 21301914; Galperin, Michael Y. 1; Email Address: galperin@ncbi.nlm.nih.gov; Koonin, Eugene V. 1; Affiliations: 1: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA; Issue Info: Apr1997, Vol. 24 Issue 2, p443; Subject Term: Letters to the editor; Subject Term: Operons; Number of Pages: 3p; Illustrations: 2 Diagrams; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104794890
T1  - Society for Research on Nicotine and Tobacco.
AU  - Heishman, S J
AU  - Balfour, D J
AU  - Benowitz, N L
AU  - Hatsukami, D K
AU  - Lindstrom, J M
AU  - Ockene, J K
Y1  - 1997/05//
N1  - Accession Number: 104794890. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Brain -- Drug Effects
KW  - Nicotine -- Pharmacodynamics
KW  - Smoking -- Therapy
KW  - Adolescence
KW  - Receptors, Cholinergic -- Physiology
KW  - Smoking Cessation
SP  - 615
EP  - 633
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 92
IS  - 5
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - The proceedings of the second annual scientific conference of the Society for Research on Nicotine and Tobacco are summarized. The goal of the annual conference was to disseminate information about ongoing nicotine research from biological, behavioral and social perspectives. Data were presented describing our current understanding of the structure and function of neuronal nicotinic acetylcholine receptors, by which nicotine exerts most, if not all, of its effects in the brain. The conformational complexity of receptor subunits expressed in different brain areas contributes significantly to the complexity of responses observed to nicotinic agonists. Nicotine is being developed as a medication that might be used to maintain smoking cessation and to treat various medical diseases. The potential toxicity of nicotine, apart from cigarette smoking, is an important variable in assessing the benefits and risks of such therapeutic applications. The risks of nicotine-containing medications appear to be far less than those associated with tobacco use. Recent data indicate that cigarette smoking is increasing among young in the United States. Adolescent smokers are interested in quitting and make frequent quit attempts, but are usually not successful. Effective methods are needed to manage adolescent smokers before they become heavily addicted. Nicotine replacement as a pharmacological treatment for smoking cessation has made a significant contribution in improving quit rates. New medications have been developed that target specific populations of smokers.
SN  - 0965-2140
AD  - Clinical Pharmacology Branch, National Institute on Drug Abuse, Baltimore, Maryland, USA. SHEISH@IRP.NIDA.NIH.GOV
U2  - PMID: 9219386.
DO  - 10.1111/j.1360-0443.1997.tb02919.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107259823
T1  - Elderly suicide: a multi-national view.
AU  - Pearson JL
AU  - Conwell Y
AU  - Lindesay J
AU  - Takahashi Y
AU  - Caine ED
Y1  - 1997/05//
N1  - Accession Number: 107259823. Language: English. Entry Date: 19980501. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Support provided, in part, by National Institute of Mental Health grants MH00748 and MH40381. NLM UID: 9705773. 
KW  - Suicide -- Epidemiology -- In Old Age
KW  - Suicide -- Prevention and Control -- In Old Age
KW  - Depression -- In Old Age
KW  - Depression -- Diagnosis -- In Old Age
KW  - Risk Factors -- In Old Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Funding Source
SP  - 107
EP  - 111
JO  - Aging & Mental Health
JF  - Aging & Mental Health
JA  - AGING MENT HEALTH
VL  - 1
IS  - 2
CY  - Oxfordshire, <Blank>
PB  - Routledge
AB  - Males age 75 and older have the highest rates of suicide in nearly all industrialized countries. A fairly consistent pattern of risk factors for elderly suicides, in contrast to younger victims, includes major depression diagnoses without comorbid substance use, and comorbid physical illness. Older suicides also demonstrate greater lethality of self-destructive behaviors compared to younger groups. With regard to service use, reports from the US, UK and Japan find that most of the elderly suicides have contact with a primary health care provider in the month prior to the suicide. Altogether, these findings suggest means for primary and secondary prevention efforts. This paper summarizes research findings and recent prevention efforts from several nations.
SN  - 1360-7863
AD  - NIMH, Rm 18-101, 5600 Fishers Lane, Rockville, MD 20857; e-mail: jp36u@nih.gov
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - PALLONE, THOMAS L.
AU  - KISHORE, BELLAMKONDA K.
AU  - NIELSEN, SOREN
AU  - AGRE, PETER
AU  - KNEPPER, MARK A.
T1  - Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta.
JO  - American Journal of Physiology: Renal Physiology
JF  - American Journal of Physiology: Renal Physiology
Y1  - 1997/05//
VL  - 41
IS  - 5
M3  - Article
SP  - F587
EP  - F596
SN  - 1931857X
AB  - Outer medullary descending vasa recta (OMDVR) were perfused in vitro, and volume efflux was measured by driving water movement with transmural gradients of NaCl or albumin. Consistent with mediation by water channels, p-chloromercuribenzenesulfonic acid (pCMBS) markedly inhibited volume flux induced by NaCl. Dithiothreitol reversed the inhibition. pCMBS did not significantly alter water flux induced by albumin. Osmotic water permeability (Pf) of the pCMBS-sensitive pathway of glutaraldehyde-fixed and nonfixed OMDVR was 1,102 ± 449 and 1,257 ± 718 µm/s (means ± SD), respectively. pCMBS reduced Pf to near zero, whereas diffusional water permeability in the same vessels was only slightly inhibited. Immunoreactive aquaporin-1 (AQP1) measured by enzyme-linked immunosorbent assay in collagenase-treated and untreated OMDVR was 5.2 ± 1.0 and 4.2 ± 0.4 fmol/mm, respectively, values that account well for the experimental Pf. We conclude that OMDVR water flux driven by NaCl gradients is most likely mediated by the AQP1 water channel and that NaCl and urea gradients drive water efflux in vivo by this route. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - aquaporins
KW  - chloride
KW  - kidney
KW  - microcirculation
KW  - raffinose
KW  - sodium
KW  - urinary concentration
N1  - Accession Number: 96912269; PALLONE, THOMAS L. 1,2,3,4,5 KISHORE, BELLAMKONDA K. 1,2,3,4,5 NIELSEN, SOREN 1,2,3,4,5 AGRE, PETER 1,2,3,4,5 KNEPPER, MARK A. 1,2,3,4,5; Affiliation:  1: Division of Nephrology, University of School of Medicine, Baltimore 21201-1595  2: Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore 21205  3: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1598  4: M. S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033  5: Department of Cell Biology, University of Aarhus, DK-8000 Aarhus C, Denmark; Source Info: May97, Vol. 41 Issue 5, pF587; Author-Supplied Keyword: aquaporins; Author-Supplied Keyword: chloride; Author-Supplied Keyword: kidney; Author-Supplied Keyword: microcirculation; Author-Supplied Keyword: raffinose; Author-Supplied Keyword: sodium; Author-Supplied Keyword: urinary concentration; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SHAYAKUL, CHAIRAT
AU  - KNEPPER, MARK A.
AU  - SMITH, CRAIG P.
AU  - DiGIOVANNI, SUSAN R.
AU  - HEDIGER, MATTHIAS A.
T1  - Segmental localization of urea transporter mRNAs in rat kidney.
JO  - American Journal of Physiology: Renal Physiology
JF  - American Journal of Physiology: Renal Physiology
Y1  - 1997/05//
VL  - 41
IS  - 5
M3  - Article
SP  - F654
EP  - F660
SN  - 1931857X
AB  - Renal epithelia express at least two distinct urea transporter mRNAs, termed UT1 and UT2, that are derived from a single UT gene by alternative splicing. Previous immunolocalization studies using a polyclonal antibody that does not distinguish between the protein products of these two transcripts revealed that expression of urea transporter protein is restricted to inner medullary collecting ducts and descending thin limbs of Henle's loop. To identify which transcripts account for protein expression in these two structures, we carried out reverse transcription-polymerase chain reaction studies in microdissected structures using UT1- and UT2- specific primers. UT1 mRNA was detected only in the inner medullary collecting duct, consistent with its identification as the vasopressin-regulated urea transporter. In contrast, UT2- mRNA was detected in the late part of descending thin limbs of short loops of Henle and in the inner medullary part of descending thin limbs of long loops of Henle. This localization is consistent with the predicted role of UT2 in medullary urea recycling. Thus, in conjunction with foregoing physiological studies, our data indicate that these transporters play central roles in the urinary concentrating mechanism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - collecting duct
KW  - Henle's loop
KW  - microdissection
KW  - reverse transcription-polymerase chain reaction
N1  - Accession Number: 96912278; SHAYAKUL, CHAIRAT 1,2 KNEPPER, MARK A. 3 SMITH, CRAIG P. 1,2 DiGIOVANNI, SUSAN R. 3 HEDIGER, MATTHIAS A. 1; Affiliation:  1: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115  2: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115  3: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1598; Source Info: May97, Vol. 41 Issue 5, pF654; Author-Supplied Keyword: collecting duct; Author-Supplied Keyword: Henle's loop; Author-Supplied Keyword: microdissection; Author-Supplied Keyword: reverse transcription-polymerase chain reaction; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Guralnik, Jack M.
AU  - Leveille, Suzanne G.
T1  - Annotation: Race, Ethnicity, and Health Outcomes Unraveling the Mediating Role of Socioeconomic Status.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/05//
VL  - 87
IS  - 5
M3  - Editorial
SP  - 728
EP  - 730
PB  - American Public Health Association
SN  - 00900036
AB  - The article discusses the role played by socioeconomic status in the association of race and ethnicity with disability. Because of the current focus of epidemiological research moving in the direction of identifying risk factors at the individual level, the broader public health issue of socioeconomic status has been underemphasized in relation to the magnitude of its impact on health. Low socioeconomic status is not considered among the modifiable risk factors in health-related interventions in general. Often times, it is often overlooked in planning preventive strategies.
KW  - SOCIAL status
KW  - EPIDEMIOLOGY -- Research
KW  - RACE
KW  - ETHNICITY
KW  - DISABILITIES
KW  - PUBLIC health
KW  - HEALTH—GENERAL
N1  - Accession Number: 20562762; Guralnik, Jack M. 1 Leveille, Suzanne G. 1; Affiliation:  1: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Md.; Source Info: May97, Vol. 87 Issue 5, p728; Subject Term: SOCIAL status; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: RACE; Subject Term: ETHNICITY; Subject Term: DISABILITIES; Subject Term: PUBLIC health; Author-Supplied Keyword: HEALTH—GENERAL; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Bulterys, Marc
AU  - Morgenstern, Hal
AU  - Weed, Douglas L.
T1  - Quantifying the Expected vs Potential Impact of a Risk-Factor Intervention Program.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/05//
VL  - 87
IS  - 5
M3  - Letter
SP  - 867
EP  - 868
PB  - American Public Health Association
SN  - 00900036
AB  - A letter to the editor about the potential impact of a risk-factor intervention program is presented.
KW  - LETTERS to the editor
KW  - DISEASES -- Risk factors
N1  - Accession Number: 20562755; Bulterys, Marc 1 Morgenstern, Hal 2 Weed, Douglas L. 3; Affiliation:  1: Center for Population Health, University of New Mexico Health Sciences Center, Albuquerque  2: Department of Epidemiology, School of Public Health, University of California, Los Angeles  3: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.; Source Info: May97, Vol. 87 Issue 5, p867; Subject Term: LETTERS to the editor; Subject Term: DISEASES -- Risk factors; Number of Pages: 2p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107302379
T1  - Home care in the older person.
AU  - Repetto L
AU  - Granetto C
AU  - Venturino A
Y1  - 1997/05//1997 May
N1  - Accession Number: 107302379. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8603766. 
KW  - Health Services for the Aged
KW  - Home Health Care
KW  - Neoplasms -- Therapy
KW  - Frail Elderly
KW  - Health Services for the Aged -- Economics
KW  - Health Services for the Aged -- Trends
KW  - Home Health Care -- Economics
KW  - Home Health Care -- Trends
KW  - Italy
KW  - Quality of Life
KW  - United States
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
SP  - 403
EP  - 413
JO  - Clinics in Geriatric Medicine
JF  - Clinics in Geriatric Medicine
JA  - CLIN GERIATR MED
VL  - 13
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Life expectancy has progressively increased in Western countries over the last few decades. The number of individuals over age 65 also has increased. Home health care, as an alternative to hospital and ambulatory care, is currently one of the fastest growing sectors of the health care market and has met the favor of most patients and families. Copyright (c) 1997 by W.B. Saunders Company
SN  - 0749-0690
AD  - Department of Medical Oncology I, National Cancer Institute of Genoa, Genoa, Italy
U2  - PMID: 9115458.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Scupi, Barbara S.
AU  - Benson, Brenda E.
AU  - Brown, Lauren B.
AU  - Uhde, Thomas W.
T1  - Rapid onset: A valid panic disorder criterion?
JO  - Depression & Anxiety (1091-4269)
JF  - Depression & Anxiety (1091-4269)
Y1  - 1997/05//
VL  - 5
IS  - 3
M3  - Article
SP  - 121
EP  - 126
PB  - John Wiley & Sons, Inc.
SN  - 10914269
AB  - This study examined the value of the DSM-IV time criterion for panic disorder (PD) requiring an abrupt onset to panic attacks (Pas) with a time to peak intensity (TTPI) of less than 10 min, and evaluated features distinguishing rapid onset (TTPI < 10) from prolonged onset (TTPI > 10) panickers. Eight hundred and sixty-four respondents to the National Institute of Mental Health Panic Disorder Questionnaire (NIMH PQ) who met the first three PD criteria were compared based on the time criterion. The prolonged onset panickers (18.2%) did not differ significantly from rapid onset panickers (81.8%) on any of 100 items assessing clinical symptoms, course of illness, and comorbidity of PD. These results suggest that many patients with otherwise classic features of PD have a prolonged TTPI of Pas, and that patients with prolonged-onset PAs are similar to patients with rapid-onset PAs on most measures. The reliability, validity, and clinical relevance of the current DSM-IV TTPI criterion should be evaluated in future studies. Depression and Anxiety 5:121–126, 1997. © 1997 Wiley-Liss, Inc. This article was prepared by a group consisting of both United States government employees and non-United States government employees, and as such is subject to 17 U.S.C. Sec. 105. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Depression & Anxiety (1091-4269) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PANIC disorders
KW  - COMORBIDITY
KW  - PATIENTS
KW  - MENTAL health
KW  - ANXIETY
KW  - anxiety
KW  - comorbidity
KW  - panic triggers
KW  - time criterion
N1  - Accession Number: 11772654; Scupi, Barbara S. 1 Benson, Brenda E. 1 Brown, Lauren B. 1 Uhde, Thomas W. 2; Affiliation:  1: Unit on Anxiety Disorders, Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD  2: Chairman, Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI; Source Info: 1997, Vol. 5 Issue 3, p121; Subject Term: PANIC disorders; Subject Term: COMORBIDITY; Subject Term: PATIENTS; Subject Term: MENTAL health; Subject Term: ANXIETY; Author-Supplied Keyword: anxiety; Author-Supplied Keyword: comorbidity; Author-Supplied Keyword: panic triggers; Author-Supplied Keyword: time criterion; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107243105
T1  - Model of complications of NIDDM. I. Model construction and assumptions.
AU  - Eastman RC
AU  - Javitt JC
AU  - Herman WH
AU  - Dasbach EJ
AU  - Zbrozek AS
AU  - Dong F
AU  - Manninen D
AU  - Garfield SA
AU  - Copley-Merriman C
AU  - Maier W
AU  - Eastman JF
AU  - Kotsanos J
AU  - Cowie CC
AU  - Harris M
Y1  - 1997/05//
N1  - Accession Number: 107243105. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Models, Theoretical
KW  - Computer Simulation
KW  - Diabetes Mellitus, Type 2 -- Complications
KW  - Disease Progression
KW  - Diabetic Retinopathy -- Epidemiology
KW  - Diabetic Nephropathies -- Epidemiology
KW  - Diabetic Neuropathies -- Epidemiology
KW  - Diabetes Mellitus, Type 2 -- Mortality
KW  - Cardiovascular Diseases -- Epidemiology
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
SP  - 725
EP  - 734
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 20
IS  - 5
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To develop a model of NIDDM for analyzing prevention strategies for NIDDM. RESEARCH DESIGN AND METHODS: A Markov type model with Monte Carlo techniques was used. Age, sex, and ethnicity of cohort was based on U.S. data. Incidence rates of complications were also based on community and population studies. RESULTS: Nonproliferative retinopathy, proliferative retinopathy, and macular edema are predicted in 79, 19, and 52%, respectively, of people with NIDDM; 19% are predicted to develop legal blindness. Microalbuminuria, gross proteinuria, and end-stage renal disease related to diabetes are predicted in 53, 40, and 17%, respectively. Symptomatic sensorimotor neuropathy and lower-extremity amputation are predicted in 31 and 17%, respectively. Cardiovascular disease is predicted in 39%. Higher rates of complications (1.1-3.0x) are predicted in minority populations. Predicted average life expectancy is 17 years after diagnosis. CONCLUSIONS: A probabilistic model of NIDDM predicts the vascular complications of NIDDM in a cohort representative of the incident cases of diabetes in the U.S. before age 75 years. Predictions of complications and mortality are consistent with the known epidemiology of NIDDM. The model is suitable for evaluating the effect of preventive interventions on the natural history of NIDDM.
SN  - 0149-5992
AD  - Director, Division of Diabetes, Endocrinology, and Metabolic Diseases, NIDDK, Building 31, Room 9A16, 31 Center Dr., MSC 2560, National Institutes of Health, Bethesda, MD 20892-2560
U2  - PMID: 9135934.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107243109
T1  - Model of complications of NIDDM. II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of normoglycemia.
AU  - Eastman RC
AU  - Javitt JC
AU  - Herman WH
AU  - Dasbach EJ
AU  - Copley-Merriman C
AU  - Maier W
AU  - Dong F
AU  - Manninen D
AU  - Zbrozek AS
AU  - Kotsanos J
AU  - Garfield SA
AU  - Harris M
Y1  - 1997/05//
N1  - Accession Number: 107243109. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Models, Theoretical
KW  - Computer Simulation
KW  - Diabetes Mellitus, Type 2 -- Complications
KW  - Diabetes Mellitus, Type 2 -- Economics
KW  - Economic Aspects of Illness
KW  - Cost Benefit Analysis
KW  - Diabetes Mellitus, Type 2 -- Therapy
KW  - Prospective Studies
KW  - Quality of Life
KW  - Glycemic Control
KW  - Cardiovascular Diseases -- Epidemiology
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 735
EP  - 744
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 20
IS  - 5
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To analyze the health benefits and economics of treating NIDDM with the goal of normoglycemia. RESEARCH DESIGN AND METHODS: Incidence-based simulation model of NIDDM was used. Hazard rates for complications were adjusted for glycemia using risk gradients from the Diabetes Control and Complications Trial. Treatment costs were estimated from national survey data and clinical trials. Incremental costs and benefits were expressed in present value dollars (3% discount rate). Life-years were adjusted for quality of life, yielding quality-adjusted life-years (QALYs). RESULTS: Comprehensive treatment of NIDDM that maintains an HbA1c value of 7.2% is predicted to reduce the cumulative incidence of blindness, end-stage renal disease, and lower-extremity amputation by 72, 87, and 67%, respectively. Cardiovascular disease risk increased by 3% (no effect of treating glycemia is assumed). Life expectancy increased 1.39 years. The cost of treating hyperglycemia increased by almost twofold, which is partially offset by reductions in the cost of complications. The estimated incremental cost/QALY gained is $16,002. Treatment is more cost-effective for those with longer glycemic exposure (earlier onset of diabetes), minorities, and those with higher HbA1c under standard care. CONCLUSIONS: The incremental effectiveness of treating NIDDM with the goal of normoglycemia is estimated to be approximately $16,000/QALY gained, which is in the range of interventions that are generally considered cost-effective.
SN  - 0149-5992
AD  - Director, Division of Diabetes, Endocrinology, and Metabolic Diseases, NIDDK, Building 31, Room 9A16, 31 Center Dr., MSC 2560, National Institutes of Health, Bethesda, MD 20892-2560
U2  - PMID: 9135935.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Jedlicka, Paul
AU  - Mortin, Mark A.
AU  - Wu, Carl
T1  - Multiple functions of Drosophila heat shock transcription factor in vivo.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/05//5/1/1997
VL  - 16
IS  - 9
M3  - Article
SP  - 2452
EP  - 2462
SN  - 02614189
AB  - Heat shock transcription factor (HSF) is a transcriptional activator of heat shock protein (hsp) genes in eukaryotes. In order to elucidate the physiological functions of HSF in Drosophila, we have isolated lethal mutations in the hsf gene. Using a conditional allele, we show that HSF has an essential role in the ability of the organism to survive extreme heat stress. In contrast to previous results obtained with yeast HSF, the Drosophila protein is dispensable for general cell growth or viability. However, it is required under normal growth conditions for oogenesis and early larval development. These two developmental functions of Drosophila HSF are genetically separable and appear not to be mediated through the induction of HSPs, implicating a novel action of HSF that may be unrelated to its characteristic function as a stress-responsive transcriptional activator. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSCRIPTION factors
KW  - HEAT shock proteins
KW  - DROSOPHILA
KW  - GENES
KW  - CELLULAR growth
KW  - development
KW  - heat shock
KW  - mutant
KW  - thermotolerance
KW  - transcription
N1  - Accession Number: 21785602; Jedlicka, Paul 1 Mortin, Mark A. 2 Wu, Carl 1; Email Address: carlwu@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 5E-26, Bethesda, MD 20892-4255, USA  2: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Building 37, Room 4C-09, Bethesda, MD 20892-4255, USA; Source Info: 5/1/1997, Vol. 16 Issue 9, p2452; Subject Term: TRANSCRIPTION factors; Subject Term: HEAT shock proteins; Subject Term: DROSOPHILA; Subject Term: GENES; Subject Term: CELLULAR growth; Author-Supplied Keyword: development; Author-Supplied Keyword: heat shock; Author-Supplied Keyword: mutant; Author-Supplied Keyword: thermotolerance; Author-Supplied Keyword: transcription; Number of Pages: 11p; Illustrations: 1 Color Photograph, 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3  - 10.1093/emboj/16.9.2452
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bednenko, Janna
AU  - Melek, Meni
AU  - Greene, Eric C.
AU  - Shippen, Dorothy E.
T1  - Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/05//5/1/1997
VL  - 16
IS  - 9
M3  - Article
SP  - 2507
EP  - 2518
SN  - 02614189
AB  - Telomerase serves a dual role at telomeres, maintaining tracts of telomere repeats and forming telomeres de novo on broken chromosomes in a process called chromosome healing. In ciliates, both mechanisms are readily observed. Vegetatively growing cells maintain pre-existing telomeres, while cells undergoing macronuclear development fragment their chromosomes and form telomeres de novo. Here we provide the first evidence for developmentally regulated initiation of DNA synthesis by telomerase. In vitro assays were conducted with telomerase from vegetative and developing Euplotes macronuclei using chimeric primers that contained non-telomeric 3′ ends and an upstream stretch of telomeric DNA. In developing macronuclei, chimeric primers had two fates: nucleotides were either polymerized directly onto the 3′ terminus or residues were removed from the 3′ end by endonucleolytic cleavage before polymerization began. In contrast, telomerase from vegetative macronuclei used only the cleavage pathway. Telomere repeat addition onto non-telomeric 3′ ends was lost when developing macronuclei were lysed and the contents purified on glycerol gradients. However, when fractions from the glycerol gradient were added back to partially purified telomerase, telomere synthesis was restored. The data indicate that a dissociable chromosome healing factor (CHF) collaborates with telomerase to initiate developmentally programmed de novo telomere formation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA synthesis
KW  - TELOMERASE
KW  - CHROMOSOMES
KW  - EUPLOTES
KW  - POLYMERIZATION
KW  - TELOMERES
KW  - chromosome healing
KW  - development
KW  - DNA synthesis initiation
KW  - telomerase
N1  - Accession Number: 21785597; Bednenko, Janna 1 Melek, Meni 2 Greene, Eric C. 1 Shippen, Dorothy E. 1; Affiliation:  1: Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA  2: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0540, USA; Source Info: 5/1/1997, Vol. 16 Issue 9, p2507; Subject Term: DNA synthesis; Subject Term: TELOMERASE; Subject Term: CHROMOSOMES; Subject Term: EUPLOTES; Subject Term: POLYMERIZATION; Subject Term: TELOMERES; Author-Supplied Keyword: chromosome healing; Author-Supplied Keyword: development; Author-Supplied Keyword: DNA synthesis initiation; Author-Supplied Keyword: telomerase; Number of Pages: 12p; Illustrations: 4 Diagrams; Document Type: Article
L3  - 10.1093/emboj/16.9.2507
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bristol, Douglas W.
AU  - Wachsman, Joseph T.
AU  - Greenwell, Arnold
T1  - Response.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1997/05//
VL  - 105
IS  - 5
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Focuses on the goal of predictive-toxicology evaluation (PTE) project. Involvement of researchers in development and evaluation of predictive toxicology methods; Information on workshop to analyze performance of the various predictive methods; Evaluation of aspects of PTE tests.
KW  - Toxicology
KW  - Toxicity testing
KW  - Experimental toxicology
KW  - Poisons
KW  - Seminars
KW  - Prediction theory
N1  - Accession Number: 13013429; Bristol, Douglas W. 1; Wachsman, Joseph T. 1; Greenwell, Arnold 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.; Issue Info: May1997, Vol. 105 Issue 5, p1; Thesaurus Term: Toxicology; Thesaurus Term: Toxicity testing; Thesaurus Term: Experimental toxicology; Thesaurus Term: Poisons; Subject Term: Seminars; Subject Term: Prediction theory; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Buchnan, J. Robert
AU  - Burka, Leo T.
AU  - Melnick, Roland L.
T1  - Purpose and Guidelines for Toxicokinetic Studies within the National Toxicology Program.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1997/05//
VL  - 105
IS  - 5
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Presents purpose and guidelines for toxicokinetic studies within the National Toxicology Program. Relationship between toxic effects and external exposure; Construction of comparable models to characterize target organ dosimetry in exposed humans; Description of study designs in approaches to toxicokinetic studies.
KW  - Toxicology
KW  - Hazardous substances
KW  - Experimental toxicology
KW  - Toxicity testing
KW  - Target organs (Anatomy)
KW  - Dosage of drugs
N1  - Accession Number: 13013430; Buchnan, J. Robert 1; Burka, Leo T. 2; Melnick, Roland L. 2; Affiliations: 1: Mathematics Department, Millersville University, Millersville, PA 17551 USA.; 2: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA.; Issue Info: May1997, Vol. 105 Issue 5, p1; Thesaurus Term: Toxicology; Thesaurus Term: Hazardous substances; Thesaurus Term: Experimental toxicology; Thesaurus Term: Toxicity testing; Subject Term: Target organs (Anatomy); Subject Term: Dosage of drugs; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Delphin, Christian
AU  - Huang, Kuo-Ping
AU  - Scotto, Christian
AU  - Chapel, Agnès
AU  - Vincon, Mathilde
AU  - Chambaz, Edmond
AU  - Garin, Jérome
AU  - Baudier, Jacques
T1  - The <em>in vitro</em> phosphorylation of p53 by calcium-dependent protein kinase C.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/05//5/1/97
VL  - 245
IS  - 3
M3  - Article
SP  - 684
EP  - 692
PB  - Wiley-Blackwell
SN  - 00142956
AB  - We show that, in vitro, Ca2+-dependent protein kinase C (PKC) phosphorylates recombinant murine p53 protein on several residues contained within a cocserved basic region of 25 amino acids, locuted in the C-terminal part of the protein. Accordingly, synthetic p53-(357–381)-peptide is phosphorylated by PKC at multiple Ser and Thr residues, including Ser360, Thr365, Ser370 and Thr377. We also establish that p53-(357–381)-peptide at micromolar concentrations has the ability to stimulate sequence-specific DNA binding by p53. That stimulation is lost upon phosphorylation by PKC. To further characterise the mechanisms that regulate PKC-dependent phosphorylation of p53-(357–381)-peptide, the phosphorylation of recombinant p53 and p53-(357–381)-peptide by PKC were compared. The results suggest that phosphorylation of full-length p53 on the C-terminal PKC sites is highly dependent on the accessibility of the phosphorylation sites and that a domain on p53 distinel from p53-(357–381)-peptide is involved in binding PKC. Accordingly, we have identified a conserved 27-amino-acid peptide, p53-(320–346)-peptide, within the C-terminal region of p53 and adjacent to residues 357–381 that interacts with PKC in vitro. The interaction between p53-(320–346)-peptide and PKC inhibits PKC autophosphorylation and the phosphorylation of substrates, including p53-(357–381)-peptide, neurogranin and histone HI. Conventional Ca2+-dependent PKC α β and γ and the catalytic fragment of PKC (PKM) were nearly equally susceptible to inhibition by p53-(320–346)-peptide. The Ca2+-independent PKC δ was much less sensitive to inhibition. The significance of these findings for understanding the in vivo phosphorylation of p53 by PKC are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHORYLATION
KW  - CHEMICAL reactions
KW  - PROTEIN kinase C
KW  - PROTEIN kinases
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
KW  - P53 protein
KW  - DNA-binding proteins
KW  - dna binding
KW  - p53
KW  - protein kinase c
N1  - Accession Number: 12941788; Delphin, Christian 1 Huang, Kuo-Ping 2 Scotto, Christian 3 Chapel, Agnès 4 Vincon, Mathilde 4 Chambaz, Edmond 3 Garin, Jérome 4 Baudier, Jacques 1,2,3; Email Address: Jacquo@Hofn.ceng.cea.fr; Affiliation:  1: Département de Biologie Moléculaire et Structurale du CEA, BMCC INSERM Unité 309, Grenoble, France  2: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, N1H Bethesda, USA  3: DBMS-BRCE INSERM Unité 244, Grenoble, France  4: Laboratoire de Chimie des Proteines, DBMS-CP, CEN-G, Grenoble, France; Source Info: 5/1/97, Vol. 245 Issue 3, p684; Subject Term: PHOSPHORYLATION; Subject Term: CHEMICAL reactions; Subject Term: PROTEIN kinase C; Subject Term: PROTEIN kinases; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Subject Term: P53 protein; Subject Term: DNA-binding proteins; Author-Supplied Keyword: dna binding; Author-Supplied Keyword: p53; Author-Supplied Keyword: protein kinase c; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Newitt, John A.
AU  - Bernstein, Harris D.
T1  - The N-domain of the signal recognition particle 54-kDa subunit promotes efficient signal sequence binding.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/05//5/1/97
VL  - 245
IS  - 3
M3  - Article
SP  - 720
EP  - 729
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The signal recognition particle 54-kDa subunit (SRP54) binds to the signal sequences of nascent presecretory and transmembrane proteins. Previous studies have shown that signal sequences bind to the C-terminal methionine-rich domain of the protein (M-domain), but have raised the possibility that either the N-terminal domain (N-domain) or the central guanosine triphosphatase module (GTPase-domain) also contribute to signal-sequence-binding activity. We have generated a series of N-domain and GTPase-domain mutants to investigate this issue further. Mutations in a conserved N-domain motif (ALLEADV) produced significant defects in signal sequence binding that correlate with the severity of the mutation. The magnitude of the defect was independent of the preprotein substrate, which suggested that the mutations do not alter the specificity of signal sequence recognition. The N-domain mutants also showed defects in promoting the translocation of presecretory proteins across the membrane of microsomal vesicles, but these defects appeared to be a direct consequence of the reduction in signal-sequence-binding activity and not separate effects of the mutations. By contrast, mutations in the guanosine triphosphatase consensus sequence had no effect on signal sequence binding, but instead severely impaired protein translocation activity. These results indicate that a principal function of the SRP54 N-domain is to promote efficient signal sequence binding. These data also suggest that the SRP54 GTPase regulates the cycle of signal sequence binding and release, perhaps by modulating the relative orientation of the N- and M- domains. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEOPROTEINS
KW  - RIBOSOMES
KW  - RIBOSOMES -- Structure
KW  - MOLECULAR structure
KW  - GUANOSINE triphosphate
KW  - ENDOPLASMIC reticulum
KW  - CELL organelles
KW  - endoplasmic reticulum
KW  - gtp
KW  - ribonucleoprotein
KW  - signal
KW  - signal recognition particle
N1  - Accession Number: 12941971; Newitt, John A. 1 Bernstein, Harris D. 1; Email Address: harris_bernstein@nih.gov; Affiliation:  1: Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA; Source Info: 5/1/97, Vol. 245 Issue 3, p720; Subject Term: NUCLEOPROTEINS; Subject Term: RIBOSOMES; Subject Term: RIBOSOMES -- Structure; Subject Term: MOLECULAR structure; Subject Term: GUANOSINE triphosphate; Subject Term: ENDOPLASMIC reticulum; Subject Term: CELL organelles; Author-Supplied Keyword: endoplasmic reticulum; Author-Supplied Keyword: gtp; Author-Supplied Keyword: ribonucleoprotein; Author-Supplied Keyword: signal; Author-Supplied Keyword: signal recognition particle; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Esposito, Franca
AU  - Cuccovillo, Franca
AU  - Vanoni, Marco
AU  - Cimino, Filiberto
AU  - Anderson, Carl W.
AU  - Appella, Ettore
AU  - Russo, Tommaso
T1  - Redox-mediated regulation of p21waf1/cip1 expression involves a post-transcriptional mechanism and activation of the mitogen-activated protein kinase pathway.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/05//5/1/97
VL  - 245
IS  - 3
M3  - Article
SP  - 730
EP  - 737
PB  - Wiley-Blackwell
SN  - 00142956
AB  - p21waf1/cip1 gene expression is induced by DNA damage in cells with wild-type p53 and contributes to the arrest of cell growth. It was demonstrated that under many experimental conditions, including oxidative stress, p21waf1/cip1 expression can be induced through p53-independent pathways. Since most of these experimental conditions induce the phosphorylation of mitogen-activated protein kinase (MAPK) and thus its activation, we evaluated p21waf1/cip1 mRNA levels in cells exposed to an oxidative stress, induced by diethylmaleate (Et2Mal), and in which the MAPK pathway was blocked. The expression of a dominant-negative mutant of MEK, the MAPK kinase that phosphorylates and activates MAPK, and of a dominant-negative [Asn17]Ras mutant prevented the Et2Mal-induced accumulation of p21waf1/cip1 mRNA. Similarly, the expression of MEK and of [Asn17]Ras mutants decreased the 12-O-tetradecanoyl-phorbol 13-acetate (TPA)-mediated p21waf1/cip1 induction. Furthermore, TPA-induced and serum-induced p21waf1/cip1 mRNA accumulation was blocked by pretreating the cells with the antioxidant compound N-acetyleysteine, suggesting that oxidative stress is involved in these responses. p21waf1/cip1 mRNA levels reached a maximum within 2 h of adding Et2Mal or TPA; however, the rate of trascription from a p21waf1/cip1-promoter construct did not increase during this period. In contrast, cells treated with actomycin D show an increase of p21waf1/cip1 mRNA stability after Et2Mal treatment. This result suggests that the increase in p21waf1/cip1 mRNA at early times results from post-transcriptional regulatory events. Longer exposure to TPA may activate p21waf1/cip1 gene transcription through an Sp1-dependent mechanism, while Et2Mal treatment gradually inhibits p21waf1/cip gene transcription through oxidative changes that affect Sp1 binding to DNA. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN kinases
KW  - PHOSPHOTRANSFERASES
KW  - P53 protein
KW  - DNA-binding proteins
KW  - MITOGENS
KW  - BIOCHEMICAL genetics
KW  - mitogen-activated protein kinase
KW  - p21waf1/cip1
KW  - p53
KW  - reactive oxygen species
N1  - Accession Number: 12941985; Esposito, Franca 1 Cuccovillo, Franca 1 Vanoni, Marco 2 Cimino, Filiberto 1 Anderson, Carl W. 3 Appella, Ettore 4 Russo, Tommaso 1; Email Address: russoto@ds.unina.it; Affiliation:  1: Dipartimento di Biochimica e Biotechnologie Mediche, Università degli Studi di Napoli Federico II, Naples, Italy  2: Dipartimento di Fisiologia e Biochimica Generali, Università degli Studi di Milano, Milano, Italy  3: Biology Department, Brookhaven National Laboratory, Upton NY, USA  4: Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda MA, USA; Source Info: 5/1/97, Vol. 245 Issue 3, p730; Subject Term: PROTEIN kinases; Subject Term: PHOSPHOTRANSFERASES; Subject Term: P53 protein; Subject Term: DNA-binding proteins; Subject Term: MITOGENS; Subject Term: BIOCHEMICAL genetics; Author-Supplied Keyword: mitogen-activated protein kinase; Author-Supplied Keyword: p21waf1/cip1; Author-Supplied Keyword: p53; Author-Supplied Keyword: reactive oxygen species; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Page, N. P.
AU  - Singh, D. V.
AU  - Farland, W.
AU  - Goodman, J. I.
AU  - Conolly, R. B.
AU  - Andersen, M. E.
AU  - Clewell, H. J.
AU  - Frederick, C. B.
AU  - Yamasaki, H.
AU  - Lucier, G.
T1  - Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/05//
VL  - 37
IS  - 1
M3  - Article
SP  - 16
EP  - 36
PB  - Oxford University Press / USA
SN  - 02720590
AB  - A workshop entitled “Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data” was held in Anaheim, California, in 1996 at the 35th Annual Meeting of the Society of Toxicology (SOT). This workshop was jointly sponsored by the Carcinogenesis, Risk Assessment, and Veterinary Specialty Sections of the SOT. The thrust of the workshop was to discuss the scientific basis for the revisions to the EPA Guidelines for cancer assessment and EPA's plans for their implementation. This is the first revision to the original EPA guidelines which have been in use by EPA since 1986. The principal revisions are intended to provide a framework for an increased ability to incorporate biological data into the risk assessment process. Two cases were presented, for chloroform and trichloroethylene, that demonstrated the use of the revised guidelines for specific cancer risk assessments. Using these new guidelines, nonlinear margin of exposure analyses were proposed for these chemicals instead of the linearized multistage model previously used by the EPA as the default method. The workshop participants generally applauded the planned revisions to the EPA guidelines. For the most part, they considered that the revised guidelines represented a positive step which should allow for and encourage the use of biological information in the conduct of cancer risk assessments. Several participants cautioned however that the major problem with cancer risk assessments would continue to be the inadequacy of available data on which to conduct more scientific risk assessments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Risk assessment
KW  - Trichloroethylene
KW  - Carcinogenesis
KW  - Pharmacokinetics
KW  - United States. Environmental Protection Agency
KW  - Society of Toxicology (Organization)
N1  - Accession Number: 82418338; Page, N. P. 1; Singh, D. V. 2; Farland, W. 2; Goodman, J. I. 3; Conolly, R. B. 4; Andersen, M. E. 5; Clewell, H. J. 6; Frederick, C. B. 7; Yamasaki, H. 8; Lucier, G. 9; Affiliations: 1: ToxaChemica, International, P.O. Box 10547, Gaithersburg, Maryland 20849; 2: † US EPA, NCEA-DC, Washington, DC 20460; 3: ‡ Michigan State University East Lansing, Michigan 48824; 4: CIIT, Research Triangle Park North Carolina 27709; 5: ICF/Kaiser Engineers, Research Triangle Park North Carolina 27709; 6: ICF/Kaiser Engineers Ruston, Louisiana 71270; 7: Rohm & Haas Co. Spring House, Pennsylvania 19477; 8: †† International Agency for Research on Cancer Lyon, Cedex 08, France; 9: ‡‡ National Institute for Environmental Health Sciences, Research Triangle Park North Carolina 27709; Issue Info: 1997, Vol. 37 Issue 1, p16; Thesaurus Term: Risk assessment; Thesaurus Term: Trichloroethylene; Thesaurus Term: Carcinogenesis; Subject Term: Pharmacokinetics ; Company/Entity: United States. Environmental Protection Agency ; Company/Entity: Society of Toxicology (Organization); NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 21p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Petersen, Erik
AU  - Potter, Kimberlee
AU  - Butler, John
AU  - Fishbein, Kenneth W.
AU  - Horton, Walter
AU  - Spencer, Richard G. S.
AU  - Mcfarland, Eric W.
T1  - Bioreactor and probe system for magnetic resonance microimaging and spectroscopy of chondrocytes and neocartilage.
JO  - International Journal of Imaging Systems & Technology
JF  - International Journal of Imaging Systems & Technology
Y1  - 1997/05//
VL  - 8
IS  - 3
M3  - Article
SP  - 285
EP  - 292
SN  - 08999457
AB  - We have developed a nuclear magnetic resonance (NMR)-compatible hollow fiber chondrocyte bioreactor (HFBR), permitting the noninvasive study of neocartilage under conditions optimized for cell growth and matrix expression. The system was used to investigate the properties of neocartilage which developed from embryonic chick chondrocytes. Histologic studies performed 30 days after inoculation of the HFBR with chondrocytes showed cartilage growth units demarcated by stromal layers surrounding each fiber; the tissue itself was highly cellular with abundant proteoglycan content. Spin-density, spin-lattice, and spin-spin relaxation and magnetization transfer contrast images revealed heterogeneous tissue with NMR properties that correlated well with histologic data. It was found that the apparent free water content of the neocartilage was greater than that seen in mature cartilage, even in regions of relatively low cell density. The bioenergetic profile of the cells in culture was monitored with 31P-NMR spectroscopy, and the presence of phosphocreatine was clearly demonstrated. Overall metabolic stability was confirmed between days 10 and 17 after inoculation. A significant decrease in intracellular pH with time was observed during early development of the chondrocyte system. © 1997 John Wiley & Sons, Inc. Int J Imaging Syst Technol, 8, 285–292, 1997 [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Imaging Systems & Technology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEAR magnetic resonance
KW  - BIOREACTORS
KW  - SPECTRUM analysis
KW  - CARTILAGE cells
KW  - GROWTH factors
KW  - PROTEOGLYCANS
KW  - BIOCHEMICAL engineering -- Equipment & supplies
N1  - Accession Number: 13509801; Petersen, Erik 1 Potter, Kimberlee 2 Butler, John 1 Fishbein, Kenneth W. 2 Horton, Walter 3 Spencer, Richard G. S. Mcfarland, Eric W. 1; Affiliation:  1: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080  2: Nuclear Magnetic Resonance Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224  3: Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; Source Info: May97, Vol. 8 Issue 3, p285; Subject Term: NUCLEAR magnetic resonance; Subject Term: BIOREACTORS; Subject Term: SPECTRUM analysis; Subject Term: CARTILAGE cells; Subject Term: GROWTH factors; Subject Term: PROTEOGLYCANS; Subject Term: BIOCHEMICAL engineering -- Equipment & supplies; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107252803
T1  - Considering a decision-making approach to youth violence prevention programs.
AU  - Haynie DL
AU  - Alexander C
AU  - Walters SR
Y1  - 1997/05//
N1  - Accession Number: 107252803. Language: English. Entry Date: 20050712. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0376370. 
KW  - Violence -- Prevention and Control -- In Adolescence
KW  - Decision Making -- In Adolescence
KW  - Adolescent Behavior
KW  - School Health Education
KW  - Students, High School
KW  - Communication
KW  - Problem Solving
KW  - Interpersonal Relations
KW  - Peer Group -- In Adolescence
KW  - Program Evaluation
KW  - Pilot Studies
KW  - Interviews
KW  - Audiorecording
KW  - Vignettes
KW  - Prospective Studies
KW  - Repeated Measures
KW  - Urban Areas
KW  - Adolescence
KW  - Adult
KW  - Human
SP  - 165
EP  - 170
JO  - Journal of School Health
JF  - Journal of School Health
JA  - J SCH HEALTH
VL  - 67
IS  - 5
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - The unfortunate exception to a general downturn in violent crime involves an upsurge in violence among youth. Violence often results when minor confrontations escalate. As school violence increasingly has become widespread, schools have become the location of many violence prevention efforts, few of which have been evaluated adequately. This paper focuses on enhancing decision-making skills as one approach to increase adolescents' ability to manage interpersonal violence. Adolescents can be considered fairly skilled decision-makers and their unique perspective must be considered in development of effective intervention programs. Data from a pilot study were examined for insights about adolescents' ability to make decisions in situations of interpersonal conflict.
SN  - 0022-4391
AD  - National Institute of Child Health and Development, National Institutes of Health, 6100 Executive Blvd, Room 7B05, Rockville, MD 20892
U2  - PMID: 9210100.
DO  - 10.1111/j.1746-1561.1997.tb07161.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107269064
T1  - Resistance training and the blood lactate response to resistance exercise in women.
AU  - Reynolds TH IV
AU  - Frye PA
AU  - Sforzo GA
Y1  - 1997/05//
N1  - Accession Number: 107269064. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. Instrumentation: Borg Scale of Perceived Exertion. NLM UID: 9415084. 
KW  - Lactates
KW  - Muscle Strengthening
KW  - Weight Lifting
KW  - Exercise Physiology
KW  - Heart Rate
KW  - Exertion
KW  - Lactates -- Analysis
KW  - Time Factors
KW  - Research Instruments
KW  - Analysis of Variance
KW  - T-Tests
KW  - Data Analysis Software
KW  - Adult
KW  - Female
KW  - Human
SP  - 77
EP  - 81
JO  - Journal of Strength & Conditioning Research (Allen Press Publishing Services Inc.)
JF  - Journal of Strength & Conditioning Research (Allen Press Publishing Services Inc.)
JA  - J STRENGTH CONDITION RES
VL  - 11
IS  - 2
CY  - Lawrence, Kansas
PB  - Allen Press Publishing Services Inc.
AB  - This study examined the effect of resistance training on blood lactate (BL), heart rate (HR), and rating of perceived exertion (RPE) responses to an exhaustive set of squats in 7 college-age women. Baseline testing consisted of a dual set of squats at 70 and 50% of 1-RM performed to exhaustion. Immediate postexercise BL response was elevated 6.5-fold above baseline values while HR exceeded 90% of age-predicted max. After 10 wks of resistance training, the dependent variables were assessed at Post 1 and Post 2 testing sessions. At Post 1, subjects performed a nonexhaustive set of squats using the same workload and number of repetitions completed during baseline testing. At Post 2 they performed an exhaustive set of squats at 70 and 50% of posttraining 1-RM. Immediate postexercise BL was reduced at Post 1 when compared to baseline BL. Post-2 BL was similar to baseline BL and significantly greater than Post-1 BL. Resistance training also lowered the RPE response to resistance exercise at Post 1 (p </= 0.01), but Post-2 RPE did not differ from baseline values. The HR response to resistance exercise was not altered by resistance training.
SN  - 1064-8011
AD  - National Institutes of Health, 10 Center Dr., MSC 1420, Bethesda, Maryland 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Nelson, Karin B.
AU  - Grether, Judith K.
T1  - Cerebral palsy in low-birthweight infants: Etiology and strategies for prevention.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1997/05//
VL  - 3
IS  - 2
M3  - Article
SP  - 112
EP  - 117
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - Premature infants, who now survive in greater numbers than ever before, are at increased risk for motor and other neurologic disabilities. Risk is highest at the lowest extremes of birthweight and gestational age. This article focuses on children born weighing less than 1500 g (those of very low birthweight [VLBW]), almost all of whom are very premature. Maternal infection, especially intrauterine infection, is associated with preterm delivery, increased risk of cerebral palsy (CP), and neonatal brain imaging findings related to CP risk. Administration of magnesium sulfate prenatally, for maternal preeclampsia or for tocolysis, has been associated with reduced risk of CP. Multiple births tend to be low in birthweight, but whether and to what degree VLBW twins and triplets are at additional risk of unfavorable neurologic outcome compared with VLBW singletons of similar birthweight and gestational age is not yet clear. Potential causes and indicators of birth asphyxia are apparently not major factors in CP among VLBW infants. Many but not all the predictors of low birthweight are also predictors of neurologic morbidity among VLBW infants. For example, maternal smoking is related to low or very low birthweight (but not prematurity) and is not related to risk of CP and preeclampsia has been observed in recent studies to be associated with lower CP risk. MRDD Research Reviews 3:112-117, 1997. Published 1997 Wiley-Liss, Inc.<NOTER></NOTER><NOTE>This article is a US Government work and, as such, is in the public domain in the United States of America. </NOTE> [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CEREBRAL palsy
KW  - PREMATURE infants
KW  - LOW birth weight
KW  - GESTATIONAL age
KW  - ASPHYXIA
KW  - PREECLAMPSIA
KW  - cerebral palsy
KW  - premature infants
KW  - very low birthweight
N1  - Accession Number: 11781913; Nelson, Karin B. 1; Email Address: knelson@helix.nih.gov Grether, Judith K. 2; Affiliation:  1: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.  2: California Birth Defects Monitoring Program, California Department of Health Services, Emeryville, California.; Source Info: 1997, Vol. 3 Issue 2, p112; Subject Term: CEREBRAL palsy; Subject Term: PREMATURE infants; Subject Term: LOW birth weight; Subject Term: GESTATIONAL age; Subject Term: ASPHYXIA; Subject Term: PREECLAMPSIA; Author-Supplied Keyword: cerebral palsy; Author-Supplied Keyword: premature infants; Author-Supplied Keyword: very low birthweight; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105824275
T1  - Tourette syndrome. Medical and surgical treatment of obsessive-compulsive disorder.
AU  - Rapoport JL
AU  - Inoff-Germain G
Y1  - 1997/05//1997 May
N1  - Accession Number: 105824275. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8219232. 
KW  - Brain Surgery
KW  - Obsessive-Compulsive Disorder -- Drug Therapy
KW  - Obsessive-Compulsive Disorder -- Surgery
KW  - Serotonin Uptake Inhibitors -- Therapeutic Use
SP  - 421
EP  - 428
JO  - Neurologic Clinics
JF  - Neurologic Clinics
JA  - NEUROL CLIN
VL  - 15
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Current treatment outcomes for obsessive-compulsive disorder patients are far better than in past decades, but variability in treatment response remains. Most obsessive-compulsive disorder patients, but not all, respond to antidepressant agents with prominent serotonin uptake blocking properties. Because clomipramine's usefulness is limited by side effects which often accompany its use, a considerable degree of attention has shifted to selective serotonin reuptake inhibitors. A number of studies have also provided evidence for the effectiveness of medication other than those mainly involving serotonergic function, either as augmenting agents or for comorbid disorders. Neurosurgery may be useful for highly selected subjects.Copyright © 1997 by Elsevier Inc.
SN  - 0733-8619
AD  - Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892-1600, USA.
U2  - PMID: 9115472.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Al'Absi, Mustafa
AU  - Bongard, Stephan
AU  - Buchanan, Tony
AU  - Pincomb, Gwendolyn A.
AU  - Licinjo, Julio
AU  - Lovallo, William R.
T1  - Cardiovascular and neuroendocrine adjustment to public speaking and mental arithmetic stressors.
JO  - Psychophysiology
JF  - Psychophysiology
Y1  - 1997/05//
VL  - 34
IS  - 3
M3  - Article
SP  - 266
EP  - 275
SN  - 00485772
AB  - In this study, we evaluated cardiovascular, neuroendocrine, and psychological adjustment to repeated presentations of a public speaking and a mental arithmetic task. Brief versions of mental arithmetic tasks have been used widely in previous reactivity studies, and growing attention to more socially salient tasks has led to the increased use of public speaking tasks. However, psychophysiological adjustment during extended and repeated exposure to these tasks has not been delineated. In the present study, 52 healthy men worked on three 8-min presentations of public speaking and of mental arithmetic in a repeated measure design. Both tasks produced substantial cardiovascular, adrenocorticotropic hormone, and cortisol responses; public speaking produced greater changes. Repeated presentations of public speaking produced a stable pattern of cardiac activation, whereas repetitions of the mental arithmetic initially produced large cardiac responses that changed to a more vascular tonus across task periods. Both tasks increased negative moods. However, correlations between the endocrine, cardiovascular, and negative moods were significant only during the public speaking stressor. The public speaking task is a socially relevant experimental protocol for studying reactivity in the laboratory setting and elicits relatively high, stable, and homogeneous responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PUBLIC speaking
KW  - INTERPERSONAL communication
KW  - HYDROCORTISONE
KW  - GLUCOCORTICOIDS
KW  - BLOOD pressure
KW  - HEMODYNAMICS
KW  - ACTH. Blood pressure
KW  - Cortisol
KW  - Hemodynamic adjustment
KW  - Interpersonal stress
KW  - Public speaking
N1  - Accession Number: 11673629; Al'Absi, Mustafa 1,2; Email Address: malabsi@rex.uokhse.edu Bongard, Stephan 1,2 Buchanan, Tony 2 Pincomb, Gwendolyn A. 1,2 Licinjo, Julio 3 Lovallo, William R. 1,2; Affiliation:  1: Veterans Affairs Medical Center, Oklahoma City, OK, USA.  2: Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.  3: National Institute of Mental Health, Bethesda, MD, USA.; Source Info: May1997, Vol. 34 Issue 3, p266; Subject Term: PUBLIC speaking; Subject Term: INTERPERSONAL communication; Subject Term: HYDROCORTISONE; Subject Term: GLUCOCORTICOIDS; Subject Term: BLOOD pressure; Subject Term: HEMODYNAMICS; Author-Supplied Keyword: ACTH. Blood pressure; Author-Supplied Keyword: Cortisol; Author-Supplied Keyword: Hemodynamic adjustment; Author-Supplied Keyword: Interpersonal stress; Author-Supplied Keyword: Public speaking; Number of Pages: 10p; Document Type: Article
L3  - 10.1111/1469-8986.ep11673629
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107301048
T1  - Public health & the law. The False Claims Act: litigating scientific misconduct II.
AU  - Sherman S
Y1  - 1997/05//May/Jun97
N1  - Accession Number: 107301048. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; legal case. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Legal Case: U.S. ex rel. Pamela A. Berge v. The Board of Regents of the University of Alabama et al; Civ. Action No. N-93-158 - (D.Md) (1995). NLM UID: 9716844. 
KW  - Financing, Government -- Legislation and Jurisprudence -- United States
KW  - Research Support -- Legislation and Jurisprudence -- United States
KW  - Scientific Misconduct -- Legislation and Jurisprudence -- United States
KW  - United States
KW  - Alabama
KW  - National Institutes of Health (U.S.)
KW  - Colleges and Universities
KW  - Research Personnel
SP  - 248
EP  - 248
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 112
IS  - 3
PB  - Sage Publications Inc.
SN  - 0033-3549
AD  - National Institutes of Health, Rm. 2B-50, Bldg. 31, 31 Center Drive, MSC 2111, Bethesda, MD
U2  - PMID: 9182306.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265114
T1  - Applications of genetic technologies to cancer screening, prevention, diagnosis, prognosis, and treatment.
AU  - Peters JA
Y1  - 1997/05//1997 May
N1  - Accession Number: 107265114. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Genetics
KW  - Cancer Screening
KW  - Neoplasms -- Prognosis
KW  - Neoplasms -- Diagnosis
KW  - Neoplasms -- Therapy
KW  - Genes
KW  - DNA
KW  - Cancer Patients
KW  - Neoplasms -- Prevention and Control
KW  - Chromosomes
KW  - Genetic Screening
KW  - Oncogenes
SP  - 74
EP  - 81
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 13
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - PURPOSE: To help oncology nurses to appreciate genetic contributions to carcinogenesis; to learn how genetic changes are connected to biological mechanisms underlying cancer initiation, promotion, and progression; and to become familiar with new genetic technologies being incorporated into clinical oncology practice. DATA SOURCES: Review of published professional journals and oncology textbooks. CONCLUSIONS: Molecular genetic approaches with high sensitivity and specificity offer new hope for the improved evaluation of potential carcinogens, cancer prevention, early and accurate diagnosis, more reliable prognosis, and effective treatment and monitoring of cancer. Effective translation of molecular technologies will require development of improved methods, clinical validation studies, high-quality control, multisite clinical outcome studies, and development of multidisciplinary collaborations. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses are incorporating new genetic technologies into the following areas of practice: patient education, cancer prevention and control, diagnostic and prognostic testing, and treatment. Copyright (c) 1997 by W.B. Saunders Company
SN  - 0749-2081
AD  - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1852
U2  - PMID: 9114474.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265121
T1  - The genetics of melanoma.
AU  - Fraser MC
AU  - Goldstein AM
AU  - Tucker MA
Y1  - 1997/05//1997 May
N1  - Accession Number: 107265121. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Genetics
KW  - Melanoma
KW  - Risk Factors
KW  - Oncogenes
KW  - Family History
KW  - Melanoma -- Prevention and Control
KW  - Melanoma -- Diagnosis
KW  - Melanoma -- In Infancy and Childhood
KW  - Infant
KW  - Child, Preschool
KW  - Child
SP  - 108
EP  - 114
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 13
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To review the current status and recent advances of genetic epidemiology research in familial melanoma, and the implications for primary and secondary prevention of melanoma. DATA SOURCES: Research studies, review articles, and book chapters pertaining to melanoma susceptibility factors. CONCLUSION: Molecular genetic studies examining candidate genes for melanoma are being pursued vigorously. Considering the complexities and heterogeneity in the genetics of familial melanoma, predictive testing is not currently recommended as an established method for identifying individuals with a genetic predisposition to melanoma. IMPLICATIONS FOR NURSING PRACTICE: An understanding of the genetics of melanoma will help oncology nurses in translating the appropriate clinical implications for primary and secondary prevention related to melanoma. This is a US government work. There are no restrictions on its use.
SN  - 0749-2081
AD  - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza N, Room 439, 6130 Executive Blvd, MSC 7372, Bethesda, MD 20892-7372
U2  - PMID: 9114478.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107265121&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265129
T1  - Psychological issues in cancer genetics.
AU  - Biesecker BB
Y1  - 1997/05//1997 May
N1  - Accession Number: 107265129. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Neoplasms -- Psychosocial Factors
KW  - Genetics -- Psychosocial Factors
KW  - Genetic Screening -- Psychosocial Factors
KW  - Disease Susceptibility -- Psychosocial Factors
KW  - Oncologic Nursing
SP  - 129
EP  - 134
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 13
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To review the behavioral research that addresses the impact of hereditary cancer on the family and the psychological aspects of choosing whether or not to undergo susceptibility testing. DATA SOURCES: Scientific articles and book chapters in the professional literature pertaining to the psychological aspects of cancer genetics and susceptibility testing. CONCLUSIONS: Susceptibility gene testing for a variety of rare hereditary cancer syndromes and familial cancers will offer new options and challenges to members of cancer families. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses will be involved in the identification of hereditary cancer families at risk assessment and counseling, the offer of susceptibility testing to those who may benefit, and the provision of follow-up support and referral. This is a US government work. There are no restrictions on its use.
SN  - 0749-2081
AD  - Genetic Counseling Research and Training Unit, Medical Genetics Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 9114481.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265130
T1  - Educational issues related to cancer genetics.
AU  - Jenkins J
Y1  - 1997/05//1997 May
N1  - Accession Number: 107265130. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; tables/charts; website. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Neoplasms
KW  - Oncologic Nursing -- Education
KW  - Genetics -- Education
KW  - Education, Nursing
KW  - Education, Nursing, Continuing
KW  - Information Resources
KW  - World Wide Web
SP  - 141
EP  - 144
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 13
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To discuss educational issues facing the nurse and to review opportunities for genetic education. DATA SOURCES: Published articles pertaining to cancer genetics and nursing. CONCLUSIONS: Health care providers are experiencing significant changes in their professional lives. Not only is the environment where services are provided changing, but the need for consumers to be knowledgeable and the expectations of care providers are enhanced. One significant challenge is the genetic discoveries influencing available health care. Educational preparation is crucial to the application of genetic technology in practice, research, and management of all patients. IMPLICATIONS FOR PRACTICE: The science and technology of genetics offers tremendous potential change for health care delivery. This in turn requires knowledgeable nurses to provide total patient care through the integration of genetic information. Determination of preferred methods, content, access, and evaluation is the focus of genetic educational issues. This is a US government work. There are no restrictions on its use.
SN  - 0749-2081
AD  - Medical Genetics Branch, National Center for Human Genome Research, National Institutes of Health Bethesda, MD
U2  - PMID: 9114483.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00863-004
AN  - 2006-00863-004
AU  - DeVries, A. Courtney
AU  - Young, W. Scott III
AU  - Nelson, Randy J.
T1  - Reduced Aggressive Behaviour in Mice with Targeted Disruption of the Oxytocin Gene.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1997/05//
VL  - 9
IS  - 5
SP  - 363
EP  - 368
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - DeVries, A. Courtney, Department of Zoology, University of Maryland, College Park, MD, US, 20742
N1  - Accession Number: 2006-00863-004. PMID: 9181490 Partial author list: First Author & Affiliation: DeVries, A. Courtney; Laboratories of Behavioral Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060424. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Aggressive Behavior; Genes; Mutations; Oxytocin. Minor Descriptor: Mice. Classification: Genetics (2510). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: May, 1997. 
AB  - Oxytocin (OT) has been reported to mediate aggressive and affiliative behaviours in several species. The behavioural role of OT has been established with physiological manipulations that potentially affected blood pressure, which may have indirectly affected the behaviours under study. To provide converging evidence of the physiological role of OT in aggressive behavior, wild type (WT), heterozygous (OT-/+), and homozygous (OT-/-) mutant mice were tested in two aggression paradigms. In general, there was no significant difference in aggressiveness between WT and OT-/+ mice. However, there were significant reductions in the duration of aggressive behaviors among OT-/- animals, especially in agonistic encounters within neutral arenas. The OT-/- mice did not exhibit any sensorimotor deficits or display any altered general anxiety levels that may have accounted for the observed reduction in aggressive behavior. These data indicate that aggression is mediated in part by OT in mice and that increased aggressiveness is not an obligatory phenotypic result of targeted genetic disruption of any gene. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - aggressive behavior
KW  - mice
KW  - oxytocin
KW  - gene targeting
KW  - 1997
KW  - Animal Aggressive Behavior
KW  - Genes
KW  - Mutations
KW  - Oxytocin
KW  - Mice
KW  - 1997
U1  - Sponsor: USPHS. Grant: MH 57535. Recipients: No recipient indicated
DO  - 10.1046/j.1365-2826.1997.t01-1-00589.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00863-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40021-003
AN  - 2015-40021-003
AU  - Xie, Kewei
AU  - Wang, Ti
AU  - Olafsson, Petur
AU  - Mizuno, Keiko
AU  - Lu, Bai
T1  - Activity-dependent expression of NT-3 in muscle cells in culture: Implications in the development of neuromuscular junctions.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/05//
VL  - 17
IS  - 9
SP  - 2947
EP  - 2958
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Lu, Bai, Unit on Synapse Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A38, 49 Convent Drive, MSC4480, Bethesda, MD, US, 20892-4480
N1  - Accession Number: 2015-40021-003. PMID: 9096131 Partial author list: First Author & Affiliation: Xie, Kewei; Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Olafsson, Petur. Major Descriptor: Muscles; Neurotransmission; Brain Derived Neurotrophic Factor. Minor Descriptor: Depolarization. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: May, 1997. Publication History: Accepted Date: Feb 10, 1997; Revised Date: Jan 23, 1997; First Submitted Date: Dec 2, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Although activity-dependent expression of neurotrophins has been studied extensively in the CNS, its physiological role during synapse development is not well established. At the developing neuromuscular junction in culture, exogenous application of the neurotrophin BDNF or NT-3 has been shown to acutely potentiate synaptic transmission and chronically promote synapse maturation. Using the same cell culture model, we have investigated activity-dependent neurotrophin expression in muscle cells and its role in developing neuromuscular synapses. Membrane depolarization, elicited by either depolarizing agents or repetitive electric stimulation, rapidly and specifically increased the levels of NT-3 mRNA in developing Xenopus laevis muscle cells in culture. NT-3 gene expression also was enhanced by acetylcholine (ACh), the neurotransmitter that causes muscle membrane depolarization. The effects of depolarization were mediated by increasing intracellular calcium concentration. Moreover, factor(s) induced by membrane depolarization appeared to enhance synaptic transmission at the developing neuromuscular junction. The frequency of spontaneous synaptic currents (SSCs) recorded from neuromuscular synapses was increased significantly after treatment with conditioned medium from depolarized muscle cultures. The amplitude, rise time, and decay time of SSCs were not affected, indicating a presynaptic action of the conditioned medium. The effects of the conditioned medium were blocked, partially, by the NT-3 scavenger TrkC-IgG, suggesting that the potentiation of synaptic efficacy was attributable, at least in part, to elevated NT-3 as a consequence of muscle depolarization. Thus, activity-dependent expression of muscle NT-3 may contribute to the development of the neuromuscular synapse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurotrophins
KW  - RT-PCR
KW  - activity-dependent
KW  - membrane depolarization
KW  - neuromuscular synapse
KW  - nerve
KW  - muscle co-culture
KW  - 1997
KW  - Muscles
KW  - Neurotransmission
KW  - Brain Derived Neurotrophic Factor
KW  - Depolarization
KW  - 1997
U1  - Sponsor: Swiss National Science Foundation, Switzerland. Other Details: Postdoctoral fellowship. Recipients: Olafsson, Petur
U1  - Sponsor: CIBA-Geigy Jubiläums-Stiftung. Recipients: Olafsson, Petur
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40021-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40022-010
AN  - 2015-40022-010
AU  - Keros, Sotirios
AU  - McBain, Chris J.
T1  - Arachidonic acid inhibits transient potassium currents and broadens action potentials during electrographic seizures in hippocampal pyramidal and inhibitory interneurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/05//
VL  - 17
IS  - 10
SP  - 3476
EP  - 3487
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - McBain, Chris J., Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Room 5A72, Building 49, 49 Convent Drive, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-40022-010. PMID: 9133373 Partial author list: First Author & Affiliation: Keros, Sotirios; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Keros, Sotirios. Major Descriptor: Electrophysiology; Hippocampus; Action Potentials; Arachidonic Acid; Pyramidal Neurons. Minor Descriptor: Rats; Seizures. Classification: Electrophysiology (2530). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: May, 1997. Publication History: Accepted Date: Mar 3, 1997; Revised Date: Feb 25, 1997; First Submitted Date: Jan 13, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The transient outward potassium current was studied in outside-out macropatches excised from the soma of CA1 pyramidal neurons and stratum (st.) oriens–alveus inhibitory interneurons in rat hippocampal slices. Arachidonic acid dose dependently decreased the charge transfer associated with the transient current, concomitant with an increase in the rate of current inactivation. Arachidonic acid (AA) did not affect the voltage dependence of steady state inactivation but did prolong the period required for complete recovery from inactivation. The effects of AA were mimicked by the nonmetabolizable analog of AA, 5,8,11,14-eicosatetraynoic acid, suggesting that metabolic products of AA were not responsible for the observed blocking action. In addition, AA blocked st. oriens– alveus–lacunosum-moleculare interneuron transient currents but not currents recorded from basket cell interneurons. In current clamp experiments, AA was without effect on the action potential waveform of CA1 pyramidal neurons under control recording conditions. In voltage-clamp experiments, the use of a test pulse paradigm, designed to mimic the action potential voltage trajectory, revealed that the transient current normally associated with a single spike deactivates too rapidly for AA to have an effect. Transient currents activated by longer duration 'action potential' waveforms, however, were attenuated by AA. Consistent with this finding was the observation that AA broadened interictal spikes recorded in the elevated [K+]o model of epilepsy. These data suggest that AA liberated from hippocampal neurons may act to block the transient current selectively in both CA1 pyramidal neurons and inhibitory interneurons and to broaden action potentials selectively under pathological conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - arachidonate
KW  - potassium currents
KW  - stratum oriens interneurons
KW  - fatty acids
KW  - interictal spikes
KW  - CA1
KW  - 1997
KW  - Electrophysiology
KW  - Hippocampus
KW  - Action Potentials
KW  - Arachidonic Acid
KW  - Pyramidal Neurons
KW  - Rats
KW  - Seizures
KW  - 1997
U1  - Sponsor: National Institute of Child Health and Human Development, US. Other Details: Intramural Research Training Award (IRTA). Recipients: Keros, Sotirios
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40022-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107005644
T1  - The social, economic and political impact of the global HIV/AIDS epidemic.
AU  - Kleinman DV
Y1  - 1997/05/02/May1997 Supplement
N1  - Accession Number: 107005644. Language: English. Entry Date: 20010309. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: May1997 Supplement. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9508565. 
KW  - Health Policy
KW  - HIV Infections -- Economics
KW  - HIV Infections -- Prevention and Control
KW  - Public Health
KW  - World Health
KW  - Socioeconomic Factors
KW  - Health Services Needs and Demand
KW  - Health Behavior
KW  - Acquired Immunodeficiency Syndrome -- Prevention and Control
SP  - S7
EP  - 12
JO  - Oral Diseases
JF  - Oral Diseases
JA  - ORAL DIS
VL  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVES: This paper reviews the themes emerging from reports of the many social, economic and political effects of the HIV/AIDS epidemic on individuals, nations and the world. The impact of the global HIV/AIDS epidemic has been felt in every facet of society. APPROACH: The impact of the epidemic is described in five areas: (1) challenges and changes to traditional public health approaches to infectious diseases and sexually transmitted diseases; (2) adjustments to 'standard' clinical research and drug regulatory practices; (3) emphasis on the importance of personal behaviors and behavioral approaches in controlling the epidemic; (4) revealing the complexity of and recognizing the need to monitor the impacts of HIV/AIDS; and (5) highlighting the difficulties of, and need for, the international responsiveness to address HIV/AIDS. The oral health community's response to the epidemic is briefly described. CONCLUSIONS: Although in its second decade, the epidemic is still in its early stages of evolution. The challenges lie in the development and perpetual evolution of strategies to respond to the epidemic locally while thinking and acting globally. The international oral health community is one of many that has played and must continue to play an active role in a multi-disciplinary effort needed to curb this epidemic.
SN  - 1354-523X
AD  - Deputy Director, National Institute of Dental Research, National Institutes of Health, Room 2C39, Building 31, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 9456649.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107005644&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107260309
T1  - Evaluating coronary heart disease risk. Tiles in the mosaic.
AU  - Hoeg JM
AU  - Hoeg, J M
Y1  - 1997/05/07/
N1  - Accession Number: 107260309. Language: English. Entry Date: 19980501. Revision Date: 20161112. Publication Type: journal article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Coronary Disease -- Prevention and Control
KW  - Cardiovascular Risk Factors
KW  - Arteriosclerosis -- Prevention and Control
KW  - Coronary Disease -- Familial and Genetic
KW  - Risk Assessment
KW  - Male
KW  - Adult
SP  - 1387
EP  - 1390
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 277
IS  - 17
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Section of Cell Biology, Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md, USA
AD  - Building 10, Room 7N115, National Institutes of Health, 10 Center Dr, MSC 1666, Bethesda, MD 20892-1666; e-mail: Jeff@mdb.nhibi.nih.gov
U2  - PMID: 9134945.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107260309&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105823421
T1  - Telomerase and early detection of cancer: a National Cancer Institute workshop.
AU  - Breslow RA
AU  - Shay JW
AU  - Gazdar AF
AU  - Srivastava S
Y1  - 1997/05/07/
N1  - Accession Number: 105823421. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Neoplasms -- Diagnosis
KW  - Neoplasms
KW  - Transferases -- Metabolism
KW  - Tumor Markers, Biological -- Metabolism
KW  - Genes
KW  - Incidence
KW  - Neoplasm Invasiveness
KW  - Neoplasms -- Epidemiology
KW  - Neoplasms -- Pathology
KW  - Prognosis
KW  - Time Factors
KW  - United States
SP  - 618
EP  - 623
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 9
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA.
U2  - PMID: 9150185.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105823421&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107260315
T1  - Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma.
AU  - Tucker MA
AU  - Halpern A
AU  - Holly EA
AU  - Hertge P
AU  - Elder DE
AU  - Sagebiel RW
AU  - Guerry D IV
AU  - Clark WH Jr.
AU  - Tucker, M A
AU  - Halpern, A
AU  - Holly, E A
AU  - Hartge, P
AU  - Elder, D E
AU  - Sagebiel, R W
AU  - Guerry, D 4th
AU  - Clark, W H Jr
Y1  - 1997/05/14/
N1  - Accession Number: 107260315. Language: English. Entry Date: 19980501. Revision Date: 20161112. Publication Type: journal article; pictorial; research; tables/charts. Commentary: Chabner B A, Haluska F G, Talcott J A. Screening strategies for cancer. Implications and results. (JAMA) 05/14/97; 277 (18): 1475-1476; Whitmore S E. Differentiating dysplastic nevi from melanoma. (JAMA) 08/20/97; 278 (7): 548-549. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Nevus -- Classification
KW  - Melanoma -- Epidemiology
KW  - Skin Neoplasms -- Epidemiology
KW  - Case Control Studies
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Risk Factors
KW  - Interviews
KW  - Patient History Taking
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Odds Ratio
KW  - Human
SP  - 1439
EP  - 1444
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 277
IS  - 18
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To investigate the relationship of number and type of nevi to the development of melanoma.Design: Case-control study.Setting: Outpatient clinics in referral hospitals.Patients: Cases were 716 consecutive patients with newly diagnosed melanoma identified at 2 melanoma centers between January 1, 1991, and December 31, 1992. Stratified random sampling of patients from outpatient clinics was used to identify 1014 participating controls of the same age, sex, race, and geographic distribution as the melanoma cases. All study subjects underwent an interview, a complete skin examination, photography of the most atypical nevi, and, if the patient was willing, a biopsy of the most atypical nevus.Main Outcome Measures: Number and type of nevi on the entire body were systematically reported. All diagnoses of clinically dysplastic nevi were confirmed by expert examiners.Results: Risk for melanoma was strongly related to number of small nevi, large nondysplastic nevi, and clinically dysplastic nevi. In the absence of dysplastic nevi, increased numbers of small nevi were associated with an approximately 2-fold risk, and increased numbers of both small and large nondysplastic nevi were associated with a 4-fold risk. One clinically dysplastic nevus was associated with a 2-fold risk (95% confidence interval, 1.4-3.6), while 10 or more conferred a 12-fold increased risk (95% confidence interval, 4.4-31). Congenital nevi were not associated with increased risk of melanoma.Conclusions: Although nondysplastic nevi confer a small risk, clinically dysplastic nevi confer substantial risk for melanoma. On the basis of nevus number and type, clinicians can identify a population at high risk of this epidemic cancer for screening and intervention.
SN  - 0098-7484
AD  - Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md, 20892-7372, USA
AD  - Genetic Epidemiology Branch, Executive Plaza North, Suite 439, 6130 Executive Blvd. MSC 7372, Bethesda, MA 20892-7372; e-mail: tuckerp@epndce.nci.nih.gov
U2  - PMID: 9145715.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107260315&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bottinger, Erwin P.
AU  - Jakubczak, John L.
AU  - Roberts, Ian S.
AU  - Mumy, Michelle
AU  - Hemmati, Philipp
AU  - Bagnall, Kerri
AU  - Merlino, Glenn
AU  - Wakefield, Lalage M.
T1  - Expression of a dominant-negative mutant TGF-ß type II receptor in transgenic mice reveals essential roles for TGF-ß in regulation of growth and differentiation in the exocrine pancreas.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/05/15/
VL  - 16
IS  - 10
M3  - Article
SP  - 2621
EP  - 2633
SN  - 02614189
AB  - Using a dominant-negative mutant receptor (DNR) approach in transgenic mice, we have functionally inactivated transforming growth factor-β (TGF-β) signaling in select epithelial cells. The dominant-negative mutant type II TGF-β receptor blocked signaling by all three TGF-β isoforms in primary hepatocyte and pancreatic acinar cell cultures generated from transgenic mice, as demonstrated by the loss of growth inhibitory and gene induction responses. However, it had no effect on signaling by activin, the closest TGF-β family member. DNR transgenic mice showed increased proliferation of pancreatic acinar cells and severely perturbed acinar differentiation. These results indicate that TGF-β negatively controls growth of acinar cells and is essential for the maintenance of a differentiated acinar phenotype in the exocrine pancreas in vivo. In contrast, such abnormalities were not observed in the liver. Additional abnormalities in the pancreas included fibrosis, neoangiogenesis and mild macrophage infiltration, and these were associated with a marked up-regulation of TGF-β expression in transgenic acinar cells. This transgenic model of targeted functional inactivation of TGF-β signaling provides insights into mechanisms whereby loss of TGF-β responsiveness might promote the carcinogenic process, both through direct effects on cell proliferation, and indirectly through up-regulation of TGF-βs with associated paracrine effects on stromal compartments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSFORMING growth factors-beta
KW  - TRANSFORMING growth factors
KW  - ACTIVIN
KW  - BIOLOGICAL response modifiers
KW  - LIVER cells
KW  - CELL culture
KW  - CULTURES (Biology)
KW  - TRANSGENIC mice
KW  - in vivo
KW  - receptors
KW  - signal transduction
KW  - transforming growth factor &beta
KW  - transgenic mice
N1  - Accession Number: 13005465; Bottinger, Erwin P. 1 Jakubczak, John L. 2 Roberts, Ian S. 3 Mumy, Michelle 4 Hemmati, Philipp 4 Bagnall, Kerri 4 Merlino, Glenn 2 Wakefield, Lalage M. 4; Affiliation:  1: Albert Einstein College of Medicine, Bronx, NY 10461, USA  2: Laboratory of Molecular Biology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA  3: Department of Pathological Sciences, The University of Manchester Oxford Road, Manchester M13 9PT, UK  4: Laboratory of Chemoprevention, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA; Source Info: 5/15/97, Vol. 16 Issue 10, p2621; Subject Term: TRANSFORMING growth factors-beta; Subject Term: TRANSFORMING growth factors; Subject Term: ACTIVIN; Subject Term: BIOLOGICAL response modifiers; Subject Term: LIVER cells; Subject Term: CELL culture; Subject Term: CULTURES (Biology); Subject Term: TRANSGENIC mice; Author-Supplied Keyword: in vivo; Author-Supplied Keyword: receptors; Author-Supplied Keyword: signal transduction; Author-Supplied Keyword: transforming growth factor &beta; Author-Supplied Keyword: transgenic mice; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/16.10.2621
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13005465&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104795250
T1  - Assessment of cocaine use with quantitative urinalysis and estimation of new uses.
AU  - Preston, K L
AU  - Silverman, K
AU  - Schuster, C R
AU  - Cone, E J
Y1  - 1997/06//
N1  - Accession Number: 104795250. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research; randomized controlled trial. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Cocaine -- Administration and Dosage
KW  - Narcotics -- Administration and Dosage
KW  - Substance Abuse Detection -- Methods
KW  - Substance Use Disorders -- Urine
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Cocaine -- Analogs and Derivatives
KW  - Cocaine -- Metabolism
KW  - Cocaine -- Urine
KW  - Crossover Design
KW  - Drug Administration Schedule
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Narcotics -- Metabolism
KW  - Randomized Controlled Trials
KW  - Single-Blind Studies
KW  - Substance Use Disorders -- Rehabilitation
SP  - 717
EP  - 727
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 92
IS  - 6
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - Qualitative urinalysis methods of monitoring cocaine use may over-detect frequency of use, possibly decreasing the ability of clinical trials to detect effective treatments. Quantitative urinalysis and newly developed criteria for identifying new cocaine use were evaluated as alternative measures of cocaine use. Urine specimens collected in a cocaine dosing study in non-treatment-seeking subjects (n = 5) and a cocaine treatment trial (n = 37) were analyzed for the cocaine metabolite, benzoylecgonine, with qualitative and quantitative methods. Pharmacokinetic criteria ('New Use' rules) were applied to quantitative data to identify occasions of new cocaine use. Results were compared to known cocaine administrations in the laboratory study and to self-reported drug use and qualitative urinalysis for subjects in the clinical trial. New Use criteria correctly identified cocaine administrations in the cocaine dosing study in all but a small number of specimens. In the clinical trial, quantitative urinalysis and estimated New Uses provided more information about patterns and frequency of use than qualitative urinalysis in the different treatment conditions in the clinical trial. Interpretation of quantitative urinalysis with New Use rules appears to be a useful method for monitoring treatment outcome and may be more accurate than traditional qualitative urinalysis in estimating frequency of cocaine use.
SN  - 0965-2140
AD  - National Institute on Drug Abuse, Intramural Research Program, NIH, Baltimore, MD 21224, USA.
U2  - PMID: 9246799.
DO  - 10.1111/j.1360-0443.1997.tb02938.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104795250&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107260795
T1  - Model-based approaches to studying fertility and contraceptive efficacy.
AU  - Weinberg CR
AU  - Zhou H
Y1  - 1997/06//
N1  - Accession Number: 107260795. Language: English. Entry Date: 19980501. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 8607435. 
KW  - Models, Statistical
KW  - Contraception -- Evaluation
KW  - Fertility
KW  - Contraceptive Devices
KW  - Contraceptive Agents
KW  - Pregnancy
KW  - Male
KW  - Female
SP  - 97
EP  - 103
JO  - Advances in Contraception
JF  - Advances in Contraception
JA  - ADV CONTRACEPT
VL  - 13
IS  - 2/3
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - Statistical methods recently developed to aid in identifying environmental exposures with reproductive toxicity can also be applied to trials of interventions undertaken specifically to impair fertility, i.e. methods of contraception. Although only applicable in a trial that includes a reliable benchmark for identifying the day of ovulation, the proposed measures of contraceptive efficacy derived from such a trial offer certain interpretive advantages over the more traditional approaches of evaluating contraceptives. Extensions of the same models also allow one to evaluate efficacy under any assumed pattern of imperfect use. One can also evaluate methods based on biomarkers for the fertile phase of the cycle, such as hydration of the cervical mucus, that may prove to be enormously helpful to couples who wish to use periodic abstinence as their method. In prospective studies of fertility, couples who occasionally use a barrier method should not be excluded from the study, but can be retained, without biasing the estimates for fertility parameters.
SN  - 0267-4874
AD  - Biostatistics Branch, MD A3-03, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107260795&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Riley, Matilda White
T1  - Rational Choice and the Sociology of Age: Heuristic Models.
JO  - American Sociologist
JF  - American Sociologist
Y1  - 1997///Summer97
VL  - 28
IS  - 2
M3  - Article
SP  - 54
EP  - 60
SN  - 00031232
AB  - Rational choice is contrasted with the sociology of age as two broad frameworks to aid the search for conceptual models to integrate our fragmented discipline. Some suggestive differences and convergences between them point to the desirability of a more dynamic emphasis in rational choice theory, and to consideration of the philosophical and moral assumptions underlying the "purpose" of action in the sociology of age. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Sociologist is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RATIONAL choice theory
KW  - SOCIAL choice
KW  - CHOICE (Psychology)
KW  - SOCIOLOGY
KW  - SOCIAL sciences
N1  - Accession Number: 9710101415; Riley, Matilda White 1,2,3; Affiliation:  1: Professor Emerita of Sociology, Rutgers University  2: Professor Emerita of Sociology, Bowdoin College  3: Senior Social Scientist, National Institute on Aging, National Institutes of Health; Source Info: Summer97, Vol. 28 Issue 2, p54; Subject Term: RATIONAL choice theory; Subject Term: SOCIAL choice; Subject Term: CHOICE (Psychology); Subject Term: SOCIOLOGY; Subject Term: SOCIAL sciences; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3274
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Daniels, C. E.;
AU  - Broekemeier, R. L.;
T1  - Innovation and risk in pharmacy practice: managers or leaders?
CT  - Innovation and risk in pharmacy practice: managers or leaders?
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1997/06/01/
VL  - 54
IS  - Jun
SP  - MCS
EP  - S-1
AD  - National Institutes of Health, 10 Center Drive, Room 1N257, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 34-05490; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice
N2  - This case study focuses on application of leadership principles in the dynamic environment of pharmacy in the health system organization. The case presentation uses two examples which demonstrate how changes in health care systems require a different style of leadership or direction than was required in less turbulent times. The first example uses alternative strategies for clinical program development and direction in a multiple site organization. The second example uses alternative strategies for freeing human resources to address organizational mission. Each example contrasts opportunity for innovation, and the risk/reward concept in relationship to organizational direction. Learning objectives: 1. Describe the basic characteristics of leaders. 2. Contrast a leader's style with a manager's style. 3. Describe eight steps to transforming an organization. Self-assessment questions: True or False: 1. Leaders work from low risk positions more often than managers. 2. Rapidly changing environments are best handled with a manager's style. 3. Creating a sense of urgency is crucial to transformation of an organization. Answers: 1. F; 2. F; 3. T.
KW  - Management Case Studies--meeting presentations;
KW  - ASHP meeting abstracts--pharmacy practice, leadership;
KW  - Administrators--pharmacy--practice innovation;
KW  - Clinical pharmacy--hospitals--alternative strategies;
KW  - Manpower--hospital pharmacy--alternative strategies;
KW  - Administration--leadership--hospital pharmacy;
KW  - Pharmacy, institutional, hospital--administration--practice innovation;
KW  - Pharmacy services--hospitals--practice innovation;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Shirkey, B. L.
AU  - Slavin, S.
AU  - Vistica, B. P.
AU  - Podgor, M. J.
AU  - Gery, I.
T1  - Immunomodulatory effects of linomide in animals immunized with immunopathogenic retinal antigens: dissociation between different immune functions.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1997/06//
VL  - 108
IS  - 3
M3  - Article
SP  - 539
EP  - 544
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Linomide (LS-2616, quinoline-3-carboxamide) has been reported to exert a diverse range of effects on the immune system. On one hand, this drug was found to stimulate the immune system and to enhance activities such as DTH or allograft rejection. On the other hand, linomide was shown to inhibit the induction of experimental autoimmune encephalomyelitis and myasthenia gravis, as well as the development of diabetes in non-obese diabetic (NOD) mice. Here we report the effects of linomide in animals immunized with unveitogenic retinal antigens. Treatment with linomide completely inhibited the development of experimental autoimmune uveoretinitis (EAU) in mice immunized with interphotoreceptor retinoid-binding protein and markedly suppressed EAU in rats immunized with S-antigen (S-Ag). in addition, linomide-treated rats exhibited reduced antibody production and lymphocyte proliferative response to S-Ag. In contrast to these suppressive activities, linomide treatment did not affect the development of adoptively transferred EAU in rats and moderately enhanced the DTH reactions to S-Ag in immunized rats in which EAU and other immune responses to this antigen were suppressed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CENTRAL nervous system -- Diseases
KW  - IMMUNE system
KW  - CARBOHYDRATE intolerance
KW  - DIABETICS
KW  - RETINOIDS
KW  - CARRIER proteins
KW  - autoimmune disease
KW  - immunomodulation
KW  - Linomide
KW  - uveitis
N1  - Accession Number: 15902852; Shirkey, B. L. 1,2 Slavin, S. 3 Vistica, B. P. 1 Podgor, M. J. 4 Gery, I. 1; Affiliation:  1: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.  2: Howard Hughes Medical Institute-NIH Research Scholars Program, Bethesda, MD, USA.  3: Department of Bone Marrow Transplantation & Cancer Immunobiology Research Laboratory, Hadassah University Hospital, Jerusalem, Israel.  4: Division of Biometry and Epidemiology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.; Source Info: Jun1997, Vol. 108 Issue 3, p539; Subject Term: CENTRAL nervous system -- Diseases; Subject Term: IMMUNE system; Subject Term: CARBOHYDRATE intolerance; Subject Term: DIABETICS; Subject Term: RETINOIDS; Subject Term: CARRIER proteins; Author-Supplied Keyword: autoimmune disease; Author-Supplied Keyword: immunomodulation; Author-Supplied Keyword: Linomide; Author-Supplied Keyword: uveitis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Post, Robert M.
AU  - Leverich, Gabriele S.
AU  - Denicoff, Kirk D.
AU  - Frye, Mark A.
AU  - Kimbrell, Tim A.
AU  - Dunn, Robert
T1  - Alternative approaches to refractory depression in bipolar illness.
JO  - Depression & Anxiety (1091-4269)
JF  - Depression & Anxiety (1091-4269)
Y1  - 1997/06//
VL  - 5
IS  - 4
M3  - Article
SP  - 175
EP  - 189
PB  - John Wiley & Sons, Inc.
SN  - 10914269
AB  - This article is a U.S. government work, and, as such, is in the public domain in the United States of America. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Depression & Anxiety (1091-4269) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AFFECTIVE disorders
KW  - MENTAL depression
KW  - ANTIDEPRESSANTS
KW  - MOOD (Psychology)
KW  - LITHIUM
KW  - antidepressants
KW  - bipolar illness
KW  - refractory depression
N1  - Accession Number: 11772659; Post, Robert M. 1 Leverich, Gabriele S. 1 Denicoff, Kirk D. 1 Frye, Mark A. 1 Kimbrell, Tim A. 1 Dunn, Robert 1; Affiliation:  1: Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD; Source Info: 1997, Vol. 5 Issue 4, p175; Subject Term: AFFECTIVE disorders; Subject Term: MENTAL depression; Subject Term: ANTIDEPRESSANTS; Subject Term: MOOD (Psychology); Subject Term: LITHIUM; Author-Supplied Keyword: antidepressants; Author-Supplied Keyword: bipolar illness; Author-Supplied Keyword: refractory depression; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; Number of Pages: 15p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Willert, Karl
AU  - Brink, Marcel
AU  - Wodarz, Andreas
AU  - Varmus, Harold
AU  - Nusse, Roel
T1  - Casein kinase 2 associates with and phosphorylates Dishevelled.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/06//6/1/97
VL  - 16
IS  - 11
M3  - Article
SP  - 3089
EP  - 3096
SN  - 02614189
AB  - The dishevelled (dsh) gene of Drosophila melanogaster encodes a phosphoprotein whose phosphorylation state is elevated by Wingless stimulation, suggesting that the phosphorylation of Dsh and the kinase(s) responsible for this phosphorylation are integral parts of the Wg signaling pathway. We found that immunoprecipitated Dsh protein from embryos and from cells in tissue culture is associated with a kinase activity that phosphorylates Dsh in vitro. Purification and peptide sequencing of a 38 kDa protein co-purifying with this kinase activity showed it to be identical to Drosophila Casein Kinase 2 (CK2). Tryptic phosphopeptide mapping indicates that identical peptides are phosphorylated by CK2 in vitro and in vivo, suggesting that CK2 is at least one of the kinases that phosphorylates Dsh. Overexpression of Dfz2, a Wingless receptor, also stimulated phosphorylation of Dsh, Dsh-associated kinase activity, and association of CK2 with Dsh, thus suggesting a role for CK2 in the transduction of the Wg signal. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN kinase CK2
KW  - GENES
KW  - DROSOPHILA melanogaster
KW  - PHOSPHOPROTEINS
KW  - PHOSPHORYLATION
KW  - AMINO acid sequence
KW  - GENETIC transduction
KW  - casein kinase 2
KW  - dishevelled
KW  - frizzled
KW  - wingless
KW  - wnt
N1  - Accession Number: 13005498; Willert, Karl 1,2 Brink, Marcel 1 Wodarz, Andreas 1 Varmus, Harold 3 Nusse, Roel 1; Affiliation:  1: Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA  2: Department of Biochemistry and Biophysics, University of California, San Francisco, cA  3: National Cancer Institute, National Institutes of Health, MD, USA; Source Info: 6/1/97, Vol. 16 Issue 11, p3089; Subject Term: PROTEIN kinase CK2; Subject Term: GENES; Subject Term: DROSOPHILA melanogaster; Subject Term: PHOSPHOPROTEINS; Subject Term: PHOSPHORYLATION; Subject Term: AMINO acid sequence; Subject Term: GENETIC transduction; Author-Supplied Keyword: casein kinase 2; Author-Supplied Keyword: dishevelled; Author-Supplied Keyword: frizzled; Author-Supplied Keyword: wingless; Author-Supplied Keyword: wnt; Number of Pages: 8p; Document Type: Article
L3  - 10.1093/emboj/16.11.3089
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wadman, Isobel A.
AU  - Osada, Hirotaka
AU  - Grütz, Gerald G.
AU  - Agulnick, Alan D.
AU  - Westphal, Heiner
AU  - Forster, Alan
AU  - Rabbitts, Terence H.
T1  - The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/06//6/1/97
VL  - 16
IS  - 11
M3  - Article
SP  - 3145
EP  - 3157
SN  - 02614189
AB  - The LIM-only protein Lmo2, activated by chromosomal translocations in T-cell leukaemias, is normally expressed in haematopoiesis. It interacts with TAL1 and GATA-1 proteins, but the function of the interaction is unexplained. We now show that in erythroid cells Lmo2 forms a novel DNA-binding complex, with GATA-1, TAL1 and E2A, and the recently identified LIM-binding protein Ldb1/NLI. This oligomeric complex binds to a unique, bipartite DNA motif comprising an E-box, CAGGTG, followed ∼9 bp downstream by a GATA site. In vivo assembly of the DNA-binding complex requires interaction of all five proteins and establishes a transcriptional transactivating complex. These data demonstrate one function for the LIM-binding protein Ldb1 and establish a function for the LIM-only protein Lmo2 as an obligatory component of an oligomeric, DNA-binding complex which may play a role in haematopoiesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEMATOPOIESIS
KW  - GENETIC transcription
KW  - LYMPHOBLASTIC leukemia
KW  - ADULT T-cell leukemia
KW  - PROTEINS
KW  - CARRIER proteins
KW  - haematopoiesis
KW  - ldb1
KW  - lim
KW  - rbtn2
KW  - transcription
N1  - Accession Number: 13005492; Wadman, Isobel A. 1 Osada, Hirotaka 2 Grütz, Gerald G. 1 Agulnick, Alan D. 3 Westphal, Heiner 3 Forster, Alan 1 Rabbitts, Terence H. 1; Affiliation:  1: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK  2: Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, Chikusa0ku, Nagoya, Japan  3: Laboratory of Mammalian Genes & Development, National Institute of Child Health & Human Development, NAtional Institutes of Health, Bethesda, MD, USA; Source Info: 6/1/97, Vol. 16 Issue 11, p3145; Subject Term: HEMATOPOIESIS; Subject Term: GENETIC transcription; Subject Term: LYMPHOBLASTIC leukemia; Subject Term: ADULT T-cell leukemia; Subject Term: PROTEINS; Subject Term: CARRIER proteins; Author-Supplied Keyword: haematopoiesis; Author-Supplied Keyword: ldb1; Author-Supplied Keyword: lim; Author-Supplied Keyword: rbtn2; Author-Supplied Keyword: transcription; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/16.11.3145
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jiemin Wong
AU  - Yun-Bo Shi
AU  - Wolffle, Alan P.
T1  - Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/06//6/1/97
VL  - 16
IS  - 11
M3  - Article
SP  - 3158
EP  - 3171
SN  - 02614189
AB  - Chromatin disruption and transcriptional activation are both thyroid hormone-dependent processes regulated by the heterodimer of thyroid hormone receptor and 9-cis retinoic acid receptor (TR­RXR). In the absence of hormone, TR­RXR binds to nucleosomal DNA, locally disrupts histone­DNA contacts and generates a DNase I-hypersensitive site. Chromatin-bound unliganded TR­RXR silences transcription of the Xenopus TRβA gene within a canonical nucleosomal array. On addition of hormone, the receptor directs the extensive further disruption of chromatin structure over several hundred base pairs of DNA and activates transcription. We define a domain of the TR protein necessary for directing this extensive hormone-dependent chromatin disruption. Particular TR­RXR heterodimers containing mutations in this domain are able to bind both hormone and their thyroid hormone receptor recognition element (TRE) within chromatin, yet are unable to direct the extensive hormone-dependent disruption of chromatin or to activate transcription. We distinguish the hormone-dependent disruption of chromatin and transcriptional activation as independently regulated events through the mutagenesis of basal promoter elements and by altering the position and number of TREs within the TRβA promoter. Chromatin disruption alone on a minichromosome is shown to be insufficient for transcriptional activation of the modify histones and disrupt chromatin structure TRβA gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHROMATIN
KW  - THYROID hormones
KW  - HORMONE receptors
KW  - ISOTRETINOIN
KW  - DNA
KW  - HISTONES
KW  - MUTAGENESIS
KW  - chromatin
KW  - disruption
KW  - thyroid hormone receptor
KW  - transcriptional activation
N1  - Accession Number: 13005491; Jiemin Wong 1 Yun-Bo Shi 1 Wolffle, Alan P. 1,2; Affiliation:  1: Unit on Molecular Morphogenesis, National Institute of Child Health and Human Development, NIH, Bldg 18T, Rm 106, Bethesda, MD, USA  2: Section on Molecular Biology, Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bldg 18T, Rm 106, Bethesda, MD, USA; Source Info: 6/1/97, Vol. 16 Issue 11, p3158; Subject Term: CHROMATIN; Subject Term: THYROID hormones; Subject Term: HORMONE receptors; Subject Term: ISOTRETINOIN; Subject Term: DNA; Subject Term: HISTONES; Subject Term: MUTAGENESIS; Author-Supplied Keyword: chromatin; Author-Supplied Keyword: disruption; Author-Supplied Keyword: thyroid hormone receptor; Author-Supplied Keyword: transcriptional activation; Number of Pages: 14p; Document Type: Article
L3  - 10.1093/emboj/16.11.3158
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105884223
T1  - Hormone replacement therapy and risk for breast cancer.
AU  - Brinton LA
Y1  - 1997/06//1997 Jun
N1  - Accession Number: 105884223. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8800104. 
KW  - Breast Neoplasms -- Chemically Induced
KW  - Hormone Replacement Therapy
KW  - Breast Neoplasms -- Epidemiology
KW  - Clinical Trials
KW  - Dose-Response Relationship, Drug
KW  - Drug Therapy, Combination
KW  - Female
KW  - Meta Analysis
KW  - Progestational Hormones -- Therapeutic Use
KW  - Risk Factors
SP  - 361
EP  - 378
JO  - Endocrinology & Metabolism Clinics of North America
JF  - Endocrinology & Metabolism Clinics of North America
JA  - ENDOCRINOL METAB CLIN NORTH AM
VL  - 26
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Because breast cancer will develop in one of every nine American women, even a small increase in risk associated with a widespread exposure is of substantial public health concern. Although most studies have not found ever use of estrogens to be a risk factor for breast cancer, it is not yet resolved whether current or long-term users experience some increase in risk. Given the fact that the indications for menopausal estrogen use have changed substantially over time, from short-term use for the relief of menopausal symptoms to long-term use for lifetime reduction of conditions such as cardiovascular disease and osteoporosis, it is imperative that the effects of long-term estrogen replacement on the risk for breast cancer be resolved. These studies are not without associated methodologic difficulties, with the ultimate interpretation of the association possibly dependent on the results of controlled clinical trials. Although such investigations are currently underway, the results will not be available for many years. To address more immediate concerns, continued emphasis should be placed on well-designed case-control and cohort studies. For the results to be reliable, attention must be directed to the effects of selection, recall and surveillance biases, confounding factors, detailed exposure relationships, subgroup variations, and disease associations. In addition, given the increasing trend for estrogens to be prescribed in combination with progestogens, the effects on breast tissue of this combined therapy merit immediate attention.Copyright © 1997 by Elsevier Inc.
SN  - 0889-8529
AD  - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
U2  - PMID: 9193889.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107253385
T1  - Perinatal and infant mortality: a worldwide issue... a commentary... editorial... Eur J Public Hlth 1996;6:157-8.
AU  - Akukwe C
Y1  - 1997/06//
N1  - Accession Number: 107253385. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9204966. 
KW  - Infant Mortality
KW  - Perinatal Death
KW  - World Health
KW  - Health Policy
KW  - Race Factors
KW  - Maternal Welfare
KW  - Infant, Low Birth Weight
KW  - Developing Countries
KW  - Infant, Newborn
KW  - Pregnancy
KW  - Female
SP  - 223
EP  - 225
JO  - European Journal of Public Health
JF  - European Journal of Public Health
JA  - EUR J PUBLIC HEALTH
VL  - 7
IS  - 2
PB  - Oxford University Press / USA
AB  - The editorial on perinatal and infant mortality: a worldwide issue, Eur J Public Hlth 1996;6:157-8, appropriately links reductions in perinatal and infant mortality with improvements in socioeconomic status in developing and developed countries. However, in summary discussions of the worldwide trends of infant deaths, certain critical issues that also influence the rates of perinatal and infant mortality deserve mentioning, even if briefly. These critical issues include race/ethnic status, the pre-conception health status of the mother, the past obstetrics history, the very important effect of low birth weight and preterm delivery, the effect of maternal education and the relationship between maternal mortality/morbidity and infant survival. I briefly review the relationship between infant deaths and these critical issues. Discussing these critical issues in summary articles may help advance policy and programme debate on how to reduce the rate of infant deaths worldwide effectively.
SN  - 1101-1262
AD  - National Institutes of Health, District of Columbia Initiative to Reduce Infant Mortality, District of Columbia Commission of Public Health, Washington, DC
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Casanova, Mercedes
AU  - Bell, Douglas A.
AU  - Heck, Henry d'A.
T1  - Dichloromethane Metabolism to Formaldehyde and Reaction of Formaldehyde with Nucleic Acids in Hepatocytes of Rodents and Humans with and without Glutathione S-Transferase T1 and M1 Genes.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/06//
VL  - 37
IS  - 2
M3  - Article
SP  - 168
EP  - 180
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1, mice. In humans, this reaction is catalyzed primarily by the protein product of the gene GSTT1, a member of the Theta class of GST, and perhaps to a small extent by the protein product of the gene GSTM1. Humans are polymorphic with respect to both genes. Since HCHO may bind to both DNA and RNA forming DNA-protein crosslinks (DPX) and RNA-formaldehyde adducts (RFA), respectively, these products were determined in isolated hepatocytes from B6C3F1 mice, F344 rats, Syrian golden hamsters, and humans to compare species with respect to the production of HCHO from DCM and its reaction with nucleic acids. Only mouse hepatocytes formed detectable amounts of DPX, the quantities of which corresponded well with quantities of DPX formed in the livers of mice exposed to DCM in vivo [Casanova, M., Conolly, R. B., and Heck, H. d'A. (1996). Fundam. Appl. Toxicol. 31, 103–116]. Hepatocytes from all rodent species and from humans with functional GSTT1 and GSTM1 genes formed RFA. No RFA were detected in human cells lacking these genes. Yields of RFA in hepatocytes of mice were 4-fold higher than in those of rats, 7-fold higher than in those of humans, and 14-fold higher than in those of hamsters. The RFA:DPX ratio in mouse hepatocytes incubated with DCM was approximately 9.0 ± 1.4, but it was 1.1 ± 0.3 when HCHO was added directly to the medium, indicating that HCHO generated internally from DCM is not equivalent to that added externally to cells and that it may occupy separate pools. DPX were not detected in human hepatocytes even at concentrations equivalent to an in vivo exposure of 10,000 ppm; however, the possibility that very small amounts of DPX were produced from DCM cannot be excluded, since HCHO was formed in human cells. Maximal amounts of DPXliver that might be formed in humans were predicted from the amounts in mice and the relative amounts of RFA in hepatocytes of both species. With predicted DPXliver as the dosimeter, the unit risk, the upper 95% confidence limit on the cancer risk, and the margin of exposure were calculated at several concentrations using the linearized multistage and benchmark dose methods. Since the actual delivered dose is smaller than that predicted, the results suggest that DCM poses at most a very low risk of liver cancer to humans. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Dichloromethane
KW  - Formaldehyde
KW  - Nucleic acids
KW  - Liver cells
KW  - Rodents as laboratory animals
KW  - Glutathione synthase
KW  - Transferases
N1  - Accession Number: 82422574; Casanova, Mercedes 1; Bell, Douglas A. 2; Heck, Henry d'A. 1; Affiliations: 1: Chemical Industry Institute of Toxicology P.O. Box 12137, Research Triangle Park, North Carolina 27709; 2: National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; Issue Info: 1997, Vol. 37 Issue 2, p168; Thesaurus Term: Dichloromethane; Thesaurus Term: Formaldehyde; Thesaurus Term: Nucleic acids; Subject Term: Liver cells; Subject Term: Rodents as laboratory animals; Subject Term: Glutathione synthase; Subject Term: Transferases; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Schumann, G.
AU  - Cannon, K.
AU  - Ma, W.-P.
AU  - Crouch, R.J.
AU  - Boeke, J.D.
T1  - Antiretroviral effect of a gag-RNase HI fusion gene.
JO  - Gene Therapy
JF  - Gene Therapy
Y1  - 1997/06//
VL  - 4
IS  - 6
M3  - Article
SP  - 593
PB  - Nature Publishing Group
SN  - 09697128
AB  - We have previously shown that a molecule consisting of a fusion of a Ca2+-dependent nuclease (from Staphylococcus aureus) to a retroviral coat protein specifies a potent antiviral specific for that retrovirus. Genes specifying such fusion proteins can be delivered to virus-susceptible cells, providing an antiviral gene therapy aimed at limiting virus spread. We report here the results of experiments to vary the nuclease moiety of such fusion proteins. We found that one nuclease, Serratia marcescens nuclease, was extremely toxic to host cells and hence not likely to be useful for therapeutic purposes. A second nuclease, Escherichia coli RNase HI was found to be nontoxic and highly effective against a murine leukemia virus when it was fused to the leukemia virus coat protein. The fusion protein was enzymatically active and stably expressed, without apparent toxicity to host cells. Reduction in infectious virus output was as high as 97–99%. These studies provide a model system for the development of gene therapeutic agents aimed at combating retroviral infections in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Gene Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIRETROVIRAL agents
KW  - GENE therapy
KW  - MOUSE leukemia complex
KW  - UNITED States
KW  - antiviral gene therapy
KW  - murine leukemia virus
KW  - rcas vectors
KW  - rnase hi
KW  - serratia snuclease
N1  - Accession Number: 11352064; Schumann, G. 1 Cannon, K. 1 Ma, W.-P. 2 Crouch, R.J. 2 Boeke, J.D. 1; Affiliation:  1: Department of Molecular Biology and Genetics, 725 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA  2: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, MD, USA; Source Info: Jun97, Vol. 4 Issue 6, p593; Subject Term: ANTIRETROVIRAL agents; Subject Term: GENE therapy; Subject Term: MOUSE leukemia complex; Subject Term: UNITED States; Author-Supplied Keyword: antiviral gene therapy; Author-Supplied Keyword: murine leukemia virus; Author-Supplied Keyword: rcas vectors; Author-Supplied Keyword: rnase hi; Author-Supplied Keyword: serratia snuclease; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1038/sj.gt.3300421
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Moller, D. R.
AU  - Wysocka, M.
AU  - Greenlee, B. M.
AU  - Ma, X.
AU  - Wahl, L.
AU  - Trinchieri, G.
AU  - Karp, C. L.
T1  - Inhibition of human interleukin-12 production by pentoxifylline.
JO  - Immunology
JF  - Immunology
Y1  - 1997/06//
VL  - 91
IS  - 2
M3  - Article
SP  - 197
EP  - 203
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Pharmacological control of interleukin- 12 (IL-12) production may be a key therapeutic strategy for modulating immunological diseases dominated by type-1 cytokine responses. In this study, we investigated the effects of pentoxifylline on the production of IL-12 by human blood mononuclear cells and primary human monocytes stimulated with heat-killed Staphylococcus aureus Cowan strain I (SAC) or lipopolysaccharide (LPS). Pentoxifylline potently suppressed production of IL-12 in a concentration-dependent manner. In these same experiments, tumour necrosis factor-a (TNF-α) production was inhibited and IL-10 and prostaglandin E2 (PGE2) production was enhanced by treatment with pentoxifylline. Suppression of IL-12 production by pentoxifylline was found to be independent of several known endogenous inhibitors of IL-12, such as IL-10, transforming growth factor-α (TGF-β), IL-4 and PGE2. RNase protection assays revealed that pentoxifylline inhibited accumulation of both IL-12 p40 and p35 mRNA, suggesting a predominant mRNA locus for pentoxifylline-induced IL-12 inhibition. Low levels of pentoxifylline added to the suppression of IL-12 production by suboptimal inhibiting doses of dexamethasone, suggesting that this drug combination may have therapeutic utility. These results provide a firm rationale for the use of pentoxifylline in clinical trials of immunological disorders characterized by inappropriate type-1 immune responses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-12
KW  - IMMUNOLOGIC diseases
KW  - CYTOKINES
KW  - CELLULAR immunity
KW  - PENTOXIFYLLINE
KW  - ANTI-infective agents
N1  - Accession Number: 14069471; Moller, D. R. 1 Wysocka, M. 2 Greenlee, B. M. 1 Ma, X. 2 Wahl, L. 3 Trinchieri, G. 2 Karp, C. L. 4,5; Affiliation:  1: Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA  2: Wistar Institute of Anatomy and Biology, Philadelphia, PA, USA  3: Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA  4: Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA  5: Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA; Source Info: Jun97, Vol. 91 Issue 2, p197; Subject Term: INTERLEUKIN-12; Subject Term: IMMUNOLOGIC diseases; Subject Term: CYTOKINES; Subject Term: CELLULAR immunity; Subject Term: PENTOXIFYLLINE; Subject Term: ANTI-infective agents; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107254292
T1  - Assessment of motor and process skills as a measure of IADL functioning in pharmacologic studies of people with Alzheimer's disease: a pilot study.
AU  - Oakley F
AU  - Sunderland T
AU  - Oakley, F
AU  - Sunderland, T
Y1  - 1997/06//6/ 1/1997
N1  - Accession Number: 107254292. Language: English. Entry Date: 19980401. Revision Date: 20161117. Publication Type: journal article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al); Assessment of Motor and Process Skills (AMPS) (Fisher); Clinical Dementia Rating Scale (Hughes et al); Hachinski Ischemic Scale (Hachinski et al); Global Deteriorating Scale (Reisberg et al). NLM UID: 9007918. 
KW  - Alzheimer's Disease -- Drug Therapy
KW  - Instrument Validation
KW  - Fluoxetine
KW  - Physostigmine
KW  - Selegiline
KW  - Drug Therapy, Combination
KW  - Activities of Daily Living -- In Old Age
KW  - Motor Skills -- In Old Age
KW  - Pilot Studies
KW  - Double-Blind Studies
KW  - Crossover Design
KW  - Repeated Measures
KW  - Analysis of Variance
KW  - Validation Studies
KW  - Research Instruments
KW  - Motor Skills -- Evaluation
KW  - Geriatric Functional Assessment
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 197
EP  - 206
JO  - International Psychogeriatrics
JF  - International Psychogeriatrics
JA  - INT PSYCHOGERIATR
PB  - Cambridge University Press
AB  - The purpose of this pilot study was to evaluate the usefulness of the Assessment of Motor and Process Skills (AMPS) as an outcome measure of instrumental activities of daily living (IADL) in pharmacologic studies of people with Alzheimer's disease. The AMPS simultaneously measures motor and process skills and their effect on the ability of the person to perform familiar IADL tasks. We administered the AMPS to 11 Alzheimer inpatients in a 3 1/2-month, double-blind, placebo-controlled, crossover study of fluoxetine and selegiline administered as single agents and in combination with physostigmine. Results indicated that there was a significant difference in IADL ability among study conditions for process skills, but not for motor skills, thereby suggesting that the AMPS is useful as a sensitive outcome measure of IADL ability in drug trials with this population.
SN  - 1041-6102
AD  - Occupational Therapy Section, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1604, USA
AD  - National Institutes of Health, Building 10, Room 6s235, 10 Center Drive MSC 1604, Bethesda, MD 20892-1604
U2  - PMID: 9309491.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Glied, Sherry
AU  - Hoven, Christina W.
AU  - Garrett, A. Bowen
AU  - Moore, Robert E.
AU  - Leaf, Philip
AU  - Bird, Hector R.
AU  - Goodman, Sherryl
AU  - Regier, Darrel
AU  - Alegria, Margarita
T1  - Measuring Child Mental Health Status for Services Research.
JO  - Journal of Child & Family Studies
JF  - Journal of Child & Family Studies
Y1  - 1997/06//
VL  - 6
IS  - 2
M3  - Article
SP  - 177
EP  - 190
PB  - Springer Science & Business Media B.V.
SN  - 10621024
AB  - Epidemiological studies of the prevalence of mental health disorders typically contain multiple measures of mental health, using different instruments and different informants (child, parent, and interviewer). We used the Methods for the Epidemiology of Child and Adolescents Mental Disorder (MECA) study of U.S. youth to assess the effects of employing a range of these measures in mental health services research. We examined the effect of including various measures of mental health status in regressions of income on mental health service use. The estimated effect of income on service use varied widely, depending on the measure of mental health status used. Some measures of mental health status have little explanatory power in service use regressions. Measures of mental health status based on parental assessment of impairment or need, such as the Columbia Impairment Scale, are less costly to collect and also have good explanatory power, but are more strongly correlated with income. The Non-Clinician Child Global Assessment Scale (NC-CGAS) performs best in terms of explanatory power and correlation with income. Higher income parents appeared to judge behaviors differently from lower income parents, so analyses based on measures derived from parental report may lead to an understatement of the effect of income on service use. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Child & Family Studies is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD mental health
KW  - MENTAL health services
KW  - MANAGED care plans (Medical care)
KW  - MANAGED mental health care
KW  - CHILDREN -- Health
KW  - UNITED States
KW  - child psychopathology
KW  - Impairment
KW  - Impairment.
KW  - measurement
KW  - service use
KW  - socioeconomic status
N1  - Accession Number: 9708131629; Glied, Sherry 1 Hoven, Christina W. 2 Garrett, A. Bowen 3 Moore, Robert E. 2 Leaf, Philip 4 Bird, Hector R. 5 Goodman, Sherryl 6 Regier, Darrel 7 Alegria, Margarita 8; Affiliation:  1: Assistant Professor, Division of Health Policy and Management, Columbia School of Public Health and Department of Economics, New York, NY.  2: Assistant Professor, Epidemiology in Psychiatry, Columbia University--NYS Psychiatric Institute, New York, NY.  3: Robert Wood Johnson Foundation Scholar in Health Policy Research, University of California, Berkeley, Berkeley, CA.  4: Professor, Department of Mental Hygiene, Johns Hopkins University, Baltimore, MD  5: Professor, Psychiatry, Columbia University -- NYS Psychiatric Institute, New York, NY  6: Professor, Department of Psychology, Emory University, Atlanta, GA  7: Associate Director, Epidemiology and Health Policy Research, National Institute of Mental Health, Rockville, MD  8: Associate Professor, School of Public Health, University of Puerto Rico, San Juan, PR.; Source Info: Jun97, Vol. 6 Issue 2, p177; Subject Term: CHILD mental health; Subject Term: MENTAL health services; Subject Term: MANAGED care plans (Medical care); Subject Term: MANAGED mental health care; Subject Term: CHILDREN -- Health; Subject Term: UNITED States; Author-Supplied Keyword: child psychopathology; Author-Supplied Keyword: Impairment; Author-Supplied Keyword: Impairment.; Author-Supplied Keyword: measurement; Author-Supplied Keyword: service use; Author-Supplied Keyword: socioeconomic status; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Suzuki, Itaru
AU  - Tada, Akihiro
AU  - Ollmann, Michael M.
AU  - Barsh, Gregory S.
AU  - Im, Sungbin
AU  - Lamoreux, M. Lynn
AU  - Hearing, Vincent J.
AU  - Nordlund, James J.
AU  - Abdel-Malek, Zalfa A.
T1  - Agouti Signaling Protein Inhabits Melanogenesis and the Response of Human Melanocytes to α-Melanotropin.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/06//
VL  - 108
IS  - 6
M3  - Article
SP  - 838
EP  - 842
SN  - 0022202X
AB  - In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated by the <em>extension</em> locus, which encodes the melanocortin-1 receptor (MC1R) and the <em>agouti</em> locus, which encodes a novel paracrine-signaling molecule that inhibits binding of melanocortins to the MC1R. Human melanocytes express the MC1R and respond to melanotropins with increased proliferation and eumelanogenesis, but a potential role for the human homolog of agouti-signaling protein, ASIP, in human pigmentation has not been investigated. Here we report that ASIP blocked the binding of a-melanocyte-stimulating hormone (α-MSH) to the MC1R and inhibited the effects of α-MSH on human melanocytes. Treatment of human melanocytes with 1 nM-10 nM recombinant mouse or human ASIP blocked the stimulatory effects of α-MSH on cAMP accumulation, tyrosinase activity, and cell proliferation. In the absence of exogenous α-MSH, ASIP inhibited basal levels of tyrosinase activity and cell proliferation and reduced the level of immunoreactive tyrosinase-related protein-1 (TRP-1) without significantly altering the level of immunoreactive tyrosinase. In addition, ASIP blocked the stimulatory effects of forskolin or dibutyryl cAMP, agents that act downstream from the MC1R, on tyrosinase activity and cell proliferation. These results demonstrate that the functional relationship between the agouti and MC1R gene products is similar in mice and humans and suggest a potential physiologic role for ASIP in regulation of human pigmentation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AGOUTIS
KW  - PROTEINS
KW  - MELANOGENESIS
KW  - MELANOCYTES
KW  - MSH (Hormone)
KW  - DASYPROCTIDAE
KW  - <em>melanocortin-1 receptor</em>
KW  - <em>melanogenesis</em>
KW  - agouti <em>locus</em>
KW  - extension <em>locus</em>
N1  - Accession Number: 12292572; Suzuki, Itaru 1,2 Tada, Akihiro 1,2 Ollmann, Michael M. 3 Barsh, Gregory S. 3 Im, Sungbin 2 Lamoreux, M. Lynn 4 Hearing, Vincent J. 5 Nordlund, James J. 1 Abdel-Malek, Zalfa A. 1; Affiliation:  1: POLA Laboratories, Yokohama, Japan.  2: Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, U.S.A.  3: Stanford University, Howard Hughes Medical Institute, Stanford, California, U.S.A.  4: Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, U.S.A.  5: Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun97, Vol. 108 Issue 6, p838; Subject Term: AGOUTIS; Subject Term: PROTEINS; Subject Term: MELANOGENESIS; Subject Term: MELANOCYTES; Subject Term: MSH (Hormone); Subject Term: DASYPROCTIDAE; Author-Supplied Keyword: <em>melanocortin-1 receptor</em>; Author-Supplied Keyword: <em>melanogenesis</em>; Author-Supplied Keyword: agouti <em>locus</em>; Author-Supplied Keyword: extension <em>locus</em>; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12292572
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107342595
T1  - Cancer in adults: a focus on prevention and detection in the nurse practitioner's practice.
AU  - Varricchio CG
Y1  - 1997/06//1997 Jun
N1  - Accession Number: 107342595. Language: English. Entry Date: 19971101. Revision Date: 20150819. Publication Type: Journal Article; glossary; tables/charts. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9100939. 
KW  - Neoplasms -- Prevention and Control
KW  - Neoplasms -- Diagnosis
KW  - Cancer Screening
KW  - Advanced Nursing Practice
KW  - Nurse Practitioners
KW  - Neoplasms -- Mortality
KW  - Mortality -- Trends
KW  - Neoplasms -- Classification
KW  - Neoplasms -- Epidemiology
KW  - Neoplasms -- Therapy
KW  - Male
KW  - Female
SP  - 64
EP  - 69
JO  - Nurse Practitioner Forum
JF  - Nurse Practitioner Forum
JA  - NURSE PRACT FORUM
VL  - 8
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - This article provides a very general overview of the group of diseases called cancer. The clinical practice of the nurse practitioner emphasizes health maintenance and promotion of a healthy life style. This focus can carry over into the survival phase of the cancer experience. Counseling about risk status and risk reduction are an integral part of the total approach to cancer care. These activities can be integrated into standard care delivered by the nurse practitioner. Copyright (C) 1997 W.B. Saunders Company
SN  - 1045-5485
AD  - Program Director/Nurse Consultant, National Cancer Institute, Division of Cancer Prevention and Control, 900 Rockville Pike, EPN 300, Bethesda, MD 20892
U2  - PMID: 9325897.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107244002
T1  - Occupational outcomes: perspectives and suggestions for research.
AU  - Colborn AP
AU  - Robertson SC
Y1  - 1997/06//1997 Jun
N1  - Accession Number: 107244002. Language: English. Entry Date: 19980301. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 9602488. 
KW  - Occupational Therapy
KW  - Treatment Outcomes
KW  - Process Assessment (Health Care)
KW  - Research, Occupational Therapy
KW  - Outcomes Research
SP  - 36
EP  - 39
JO  - OT Practice
JF  - OT Practice
JA  - OT PRACT
VL  - 2
IS  - 6
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
AB  - Health economists want to know whether occupational therapy does what it says it can do to improve function. To document this, say Anne Pas Colborn and Susan C. Robertson, implementing strategies for carefully defining process outcomes must become a routine part of practice.
SN  - 1084-4902
AD  - Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sherman, Claire D.
AU  - Portier, Christopher J.
T1  - The Two-Stage Model of Carcinogenesis:  Overcoming the Nonidentifiability Dilemma.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1997/06//
VL  - 17
IS  - 3
M3  - Article
SP  - 367
EP  - 374
SN  - 02724332
AB  - The two-stage mathematical model of carcinogenesis has been shown tobe nonidentifiable whenever tumor incidence data alone is used to fit the model (Hanin and Yakovlev, 1996). This lack of identifiability implies that more than one parameter vector satisfies the optimization criteria for parameter estimation, e.g., maximum likelihood estimation. A question of greater concern to persons using the two-stage model of carcinogenesis is under what conditions can identifiable parameters be obtained from the observed experimental data. We outline how to obtain identifiable parameters for the two-stage model. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogenesis
KW  - Risk assessment
KW  - Mathematical models
KW  - Simulation methods & models
KW  - Vector analysis
KW  - Stochastic systems
KW  - Mathematical model
KW  - Nonidentifiable
KW  - two-stage model.
N1  - Accession Number: 8114848; Sherman, Claire D. 1; Portier, Christopher J. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Laboratory of Computational Biology and Risk Assessment, P.O. Box 12233, Re- search Triangle Park, North Carolina 27709.; Issue Info: Jun97, Vol. 17 Issue 3, p367; Thesaurus Term: Carcinogenesis; Thesaurus Term: Risk assessment; Thesaurus Term: Mathematical models; Thesaurus Term: Simulation methods & models; Subject Term: Vector analysis; Subject Term: Stochastic systems; Author-Supplied Keyword: Mathematical model; Author-Supplied Keyword: Nonidentifiable; Author-Supplied Keyword: two-stage model.; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107337554
T1  - Gene therapy for cancer.
AU  - Blaese RM
Y1  - 1997/06//
N1  - Accession Number: 107337554. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; tables/charts. Journal Subset: Consumer Health; USA. NLM UID: 0404400. 
KW  - Gene Therapy
KW  - Neoplasms -- Therapy
KW  - Immunization
KW  - Immunotherapy
KW  - Acquired Immunodeficiency Syndrome -- Therapy
SP  - 111
EP  - 123
JO  - Scientific American
JF  - Scientific American
JA  - SCI AM
VL  - 276
IS  - 6
CY  - New York, New York
PB  - Scientific American
SN  - 0036-8733
AD  - Clinical Gene Therapy Branch of the National Human Genome Research Institute of the National Institutes of Health
U2  - PMID: 9163943.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107337554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107282612
T1  - Lack of colon cancer coverage in seven women's magazines.
AU  - Gerlach KK
AU  - Marino C
AU  - Weed DL
AU  - Hoffman-Goetz L
Y1  - 1997/06//
N1  - Accession Number: 107282612. Language: English. Entry Date: 19980901. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421509. 
KW  - Colonic Neoplasms -- Prevention and Control
KW  - Health Education
KW  - Serial Publications
KW  - Women's Health
KW  - Colonic Neoplasms -- Epidemiology
KW  - Female
KW  - United States
KW  - Confidence Intervals
KW  - Interrater Reliability
KW  - Descriptive Statistics
KW  - Bias (Research)
KW  - Human
SP  - 57
EP  - 68
JO  - Women & Health
JF  - Women & Health
JA  - WOMEN HEALTH
VL  - 26
IS  - 2
PB  - Taylor & Francis Ltd
AB  - Women's magazines are an important source of health information. To evaluate the relevancy of articles in these publications to known disease risks, seven women's magazines were reviewed to assess their coverage of colon cancer, the third leading cause of cancer mortality in U.S. women. Specifically, the amount of coverage devoted to colon cancer as well as the presentation of issues in the prevention, risks, treatment, diagnosis and genetics of colon cancer were recorded. Twenty articles were published on colon cancer in these magazines during the years 1987-1995. Compared to five other cancers that also affect women, colon cancer was the focus of the fewest articles in the seven magazines analyzed.
SN  - 0363-0242
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD
U2  - PMID: 9472955.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107282612&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-40100-006
AN  - 2015-40100-006
AU  - Maurer, Jennifer A.
AU  - Wray, Susan
T1  - Neuronal dopamine subpopulations maintained in hypothalamic slice explant cultures exhibit distinct tyrosine hydroxylase mRNA turnover rates.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/06//
VL  - 17
IS  - 12
SP  - 4552
EP  - 4561
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wray, Susan, Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 36, Room 4D10, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-40100-006. PMID: 9169516 Partial author list: First Author & Affiliation: Maurer, Jennifer A.; Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Maurer, Jennifer A. Major Descriptor: Dopamine; Hypothalamus; Neurons; Tyrosine; mRNA. Minor Descriptor: Hydroxylases; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jun, 1997. Publication History: Accepted Date: Mar 31, 1997; Revised Date: Mar 28, 1997; First Submitted Date: Jan 28, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Changes in mRNA stability have been shown to regulate critical intracellular processes. In this investigation, we studied tyrosine hydroxylase (TH) mRNA turnover in functionally and anatomically distinct dopaminergic (DA) populations of the rat hypothalamus. To this end, long-term slice explant cultures from postnatal, preoptic area/hypothalami, containing three anatomically discrete DA populations, were generated and maintained under defined conditions. The organotypic cultures were treated with the transcription inhibitors 5,6-dichloro-1-D-ribofuranosylbenzimidazole or actinomycin D and processed for in situ hybridization histochemistry. Relative TH mRNA content per cell was quantitated. Single-cell analysis showed marked differences in basal TH mRNA turnover rates between DA neuronal populations. Anterior and midhypothalamic DA neurons exhibited half-time turnovers of 9–12 and 11–23 hr, respectively. In contrast, in the caudal hypothalamus, DA neurons of the arcuate nucleus had a significantly lower baseline level and more rapid turnover (6–7 hr) of TH mRNA. This investigation shows that basal turnover of a phenotypic mRNA, TH mRNA in DA neurons, is not an intrinsic property of the phenotypic marker. Furthermore, we found that destabilization of TH mRNA in the caudal hypothalamus corresponds to the known rhythmic output displayed by arcuate DA cells and, as such, may be critical for normal function of this population. We propose that intrinsic differences in the post-transcriptional regulation of TH permits neuronal subpopulations, which subserve different physiological functions, an additional mechanism to control DA biosynthesis in response to their unique needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - gene expression
KW  - mRNA stability
KW  - organotypic
KW  - arcuate nucleus
KW  - DRB
KW  - actinomycin D
KW  - 1997
KW  - Dopamine
KW  - Hypothalamus
KW  - Neurons
KW  - Tyrosine
KW  - mRNA
KW  - Hydroxylases
KW  - Rats
KW  - 1997
U1  - Sponsor: National Institutes of Health, National Institute of General Medical Sciences, US. Other Details: Pharmacology Research Associate Fellow. Recipients: Maurer, Jennifer A.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40100-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Sakai, Chie
AU  - Ollmann, Michael
AU  - Kobayashi, Takeshi
AU  - Abdel-Malek, Zalfa
AU  - Muller, Jacqueline
AU  - Vieira, Wilfred D.
AU  - Imokawa, Genji
AU  - Barsh, Gregory S.
AU  - Hearing, Vincent J.
T1  - Modulation of murine melanocyte function in vitro by agouti signal protein.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/06/15/
VL  - 16
IS  - 12
M3  - Article
SP  - 3544
EP  - 3552
SN  - 02614189
AB  - Molecular and biochemical mechanisms that switch melanocytes between the production of eumelanin or pheomelanin involve the opposing action of two intercellular signaling molecules, α-melanocyte-stimulating hormone (MSH) and agouti signal protein (ASP). In this study, we have characterized the physiological effects of ASP on eumelanogenic melanocytes in culture. Following exposure of black melan-a murine melanocytes to purified recombinant ASP in vitro, pigmentation was markedly inhibited and the production of eumelanosomes was decreased significantly. Melanosomes that were produced became pheomelanosome­like in structure, and chemical analysis showed that eumelanin production was significantly decreased. Melanocytes treated with ASP also exhibited time and dose-dependent decreases in melanogenic gene expression, including those encoding tyrosinase and tyrosinase­related proteins 1 and 2. Conversely, melanocytes exposed to MSH exhibited an increase in tyrosinase gene expression and function. Simultaneous addition of ASP and MSH at approximately equimolar concentrations produced responses similar to those elicited by the hormone alone. These results demonstrate that eumelanogenic melanocytes can be induced in culture by ASP to exhibit features characteristic of pheomelanogenesis in vivo. Our data are consistent with the hypothesis that the effects of ASP on melanocytes are not mediated solely by inhibition of MSH binding to its receptor, and provide a cell culture model to identify novel factors whose presence is required for pheomelanogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MELANOCYTES
KW  - EPITHELIAL cells
KW  - MSH (Hormone)
KW  - PEPTIDE hormones
KW  - PHENOL oxidase
KW  - OXIDASES
KW  - MELANOGENESIS
KW  - BIOSYNTHESIS
KW  - agouti
KW  - melanogenesis
KW  - pheomelanin
KW  - pigmentation
KW  - tyrosinase
N1  - Accession Number: 13005533; Sakai, Chie 1 Ollmann, Michael 2 Kobayashi, Takeshi 1,3 Abdel-Malek, Zalfa 4 Muller, Jacqueline 5 Vieira, Wilfred D. 1 Imokawa, Genji 3 Barsh, Gregory S. 2 Hearing, Vincent J. 1; Affiliation:  1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD  2: Department of Pediatrics, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA  3: Kao Institute for Fundamental Research, Haga, Tochigi, Japan  4: Department of Dermatology, University of Cincinnati, Cincinnati, OH  5: Division of Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: 6/15/97, Vol. 16 Issue 12, p3544; Subject Term: MELANOCYTES; Subject Term: EPITHELIAL cells; Subject Term: MSH (Hormone); Subject Term: PEPTIDE hormones; Subject Term: PHENOL oxidase; Subject Term: OXIDASES; Subject Term: MELANOGENESIS; Subject Term: BIOSYNTHESIS; Author-Supplied Keyword: agouti; Author-Supplied Keyword: melanogenesis; Author-Supplied Keyword: pheomelanin; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: tyrosinase; Number of Pages: 9p; Document Type: Article
L3  - 10.1093/emboj/16.12.3544
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Aki, Tsunehiro
AU  - Adhya, Sankar
T1  - Repressor induced site-specific binding of HU for transcriptional regulation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/06/15/
VL  - 16
IS  - 12
M3  - Article
SP  - 3666
EP  - 3674
SN  - 02614189
AB  - Transcription from two overlapping gal promoters is repressed by Gal repressor binding to bipartite gal operators, OE and OI, which flank the promoters. Concurrent repression of the gal promoters also requires the bacterial histone-like protein HU which acts as a co-factor. Footprinting experiments using iron-EDTA-coupled HU show that HU binding to gal DNA is orientation specific and is specifically dependent upon binding of GalR to both OE and OI. We propose that HU, in concert with GalR, forms a specific nucleoand protein higher order complex containing a DNA loop. This way, HU deforms the promoter to make the latter inactive for transcription initiation while remaining sensitive to inducer. The example of gal repression provides a model for studying how a ‘condensed’ DNA becomes available for transcription. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - NUCLEIC acids
KW  - DEOXYRIBOSE
KW  - ESCHERICHIA coli
KW  - ESCHERICHIA
KW  - OPERONS
KW  - GENETIC transcription
KW  - GENETIC regulation
KW  - dna loop
KW  - dna&shy
KW  - escherichia coli
KW  - gal operon
KW  - histone&shy
KW  - like protein
KW  - multiprotein complex
N1  - Accession Number: 13005521; Aki, Tsunehiro 1 Adhya, Sankar 1; Affiliation:  1: Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Source Info: 6/15/97, Vol. 16 Issue 12, p3666; Subject Term: DNA; Subject Term: NUCLEIC acids; Subject Term: DEOXYRIBOSE; Subject Term: ESCHERICHIA coli; Subject Term: ESCHERICHIA; Subject Term: OPERONS; Subject Term: GENETIC transcription; Subject Term: GENETIC regulation; Author-Supplied Keyword: dna loop; Author-Supplied Keyword: dna&shy; Author-Supplied Keyword: escherichia coli; Author-Supplied Keyword: gal operon; Author-Supplied Keyword: histone&shy; Author-Supplied Keyword: like protein; Author-Supplied Keyword: multiprotein complex; Number of Pages: 9p; Document Type: Article
L3  - 10.1093/emboj/16.12.3666
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107250751
T1  - Pain's hidden face.
AU  - Macaluso J
AU  - Samson D
Y1  - 1997/06/16/1997 Jun 16
N1  - Accession Number: 107250751. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Nursing; USA. NLM UID: 9421079. 
KW  - Chronic Pain -- Prevention and Control
KW  - Nurse-Patient Relations
SP  - 8
EP  - 9
JO  - Nursing Spectrum -- Washington DC & Baltimore Edition
JF  - Nursing Spectrum -- Washington DC & Baltimore Edition
JA  - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL  - 7
IS  - 12
CY  - Falls Church, VA 22042, Illinois
PB  - Gannett Healthcare Group
SN  - 1098-9153
AD  - Clinical Center of the National Institutes of Health, Bethesda, MD
U2  - PMID: 9431201.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107250751&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106899744
T1  - Cohort study of effect of being overweight and change in weight on risk of coronary heart disease in old age.
AU  - Harris TB
AU  - Launer LJ
AU  - Madans J
AU  - Feldman JJ
Y1  - 1997/06/21/
N1  - Accession Number: 106899744. Language: English. Entry Date: 20020208. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101090866. 
KW  - Coronary Disease -- Epidemiology
KW  - Obesity -- Complications
KW  - Weight Gain
KW  - Weight Loss
KW  - Coronary Disease -- Etiology
KW  - Obesity -- Epidemiology
KW  - Body Mass Index
KW  - United States
KW  - Coronary Disease -- Risk Factors
KW  - Prospective Studies
KW  - Epidemiological Research
KW  - Chi Square Test
KW  - Cox Proportional Hazards Model
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Male
KW  - Human
SP  - 1791
EP  - 1794
JO  - BMJ: British Medical Journal (International Edition)
JF  - BMJ: British Medical Journal (International Edition)
JA  - BMJ
VL  - 314
IS  - 7097
PB  - BMJ Publishing Group
SN  - 0959-8146
AD  - Chief, Geriatric Epidemiology Office, Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD
U2  - PMID: 9224080.
DO  - 10.1136/bmj.314.7097.1791
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hashimoto, Kenji
AU  - Tomitaka, Shin-Ichiro
AU  - Hashimoto, K
AU  - Tomitaka, S
AU  - Narita, N
AU  - Minabe, Y
AU  - Iyo, M
T1  - Induction of Fos protein by 3,4- methylenedioxymethamphetamine (Ecstasy) in rat brain: regional differences in pharmacological manipulation.
JO  - Addiction Biology
JF  - Addiction Biology
Y1  - 1997/07//
VL  - 2
IS  - 3
M3  - journal article
SP  - 317
EP  - 326
PB  - Wiley-Blackwell
SN  - 13556215
AB  - Psychostimulant drugs have been reported to increase the expression of some immediate-early genes in the brain. In the present study, immunohistochemical techniques were used to assess the pattern of Fos protein produced by 3,4-methylenedioxymethamphetamine (MDMA) in several brain regions. Furthermore, we also studied the role of the dopamine D and D receptors and the N-methyl- D-aspartate (NMDA) receptor in the induction of Fos protein by MDMA. A single administration of MDMA (5, 10 or 20 mg/kg) caused marked induction of Fos-immunoreactivity in several regions including frontal cortex, striatum and olfactory tubercle of rat brain, in a dose-dependent manner. However, in the hippocampus and cerebellum, there were few or no Fos immunoreactive cells induced by MDMA. Furthermore, the induction of Fos protein in the striatum and olfactory tubercle after administration of MDMA (10 mg/kg) was blocked by pre-treatment with the dopamine D receptor antagonist SCH 23390 (1 mg/kg) or the NMDA receptor antagonist dizocilpine (1 mg/kg), but not by the dopamine D receptor antagonist (-)-sulpiride (100 mg/kg). However, the induction of Fos protein in the frontal cortex and hippocampus by MDMA was unaltered by pretreatment with SCH 23390 (1 mg/kg) or (-)-sulpiride (100 mg/kg). These results suggest that MDMA induces the expression of Fos protein in several regions of rat brain, and that the expression of Fos protein by MDMA in the striatum and olfactory tubercle appears to be mediated at least in part by the dopamine D and NMDA receptors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Addiction Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ECSTASY (Drug)
KW  - BRAIN
KW  - RATS
KW  - PHYSIOLOGY
KW  - DRUGS
N1  - Accession Number: 9708041044; Hashimoto, Kenji Tomitaka, Shin-Ichiro Hashimoto, K 1 Tomitaka, S 1 Narita, N 1 Minabe, Y 1 Iyo, M 1; Affiliation:  1: Division of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo.Division of Drug Dependence and Psychotropic Drug Clinical Research, National Institute of Mental Health, Chiba, Japan; Source Info: Jul97, Vol. 2 Issue 3, p317; Subject Term: ECSTASY (Drug); Subject Term: BRAIN; Subject Term: RATS; Subject Term: PHYSIOLOGY; Subject Term: DRUGS; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 24 Black and White Photographs, 2 Graphs; Document Type: journal article; Full Text Word Count: 3559
L3  - 10.1080/13556219772615
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107271245
T1  - Evaluation of musculoskeletal disability: current concepts and practice: a commentary.
AU  - Shah JP
AU  - Gerber LH
Y1  - 1997/07//1997 Jul-Aug
N1  - Accession Number: 107271245. Language: English. Entry Date: 19980701. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8803677. 
KW  - Disability Evaluation
KW  - Musculoskeletal Diseases -- Rehabilitation
KW  - Work Capacity Evaluation
SP  - 344
EP  - 347
JO  - American Journal of Physical Medicine & Rehabilitation
JF  - American Journal of Physical Medicine & Rehabilitation
JA  - AM J PHYS MED REHABIL
VL  - 76
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0894-9115
AD  - National Institutes of Health, Rehabilitation Medicine Department, Room 6S235, Bethesda, Maryland 20892
U2  - PMID: 9267197.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Schatzkin, Arthur
T1  - Annotation: Disparity in Cancer Survival and Alternative Health Care Financing Systems.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/07//
VL  - 87
IS  - 7
M3  - Article
SP  - 1095
EP  - 1096
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents an annotation to a study about the disparity in cancer survival and alternative healthcare financing systems in different U.S. states. Biological, behavioral and social systemic factors influence the survival of cancer patients. These factors include smoking, body size, diet, alcohol intake, use of medication, chemical exposure and immune status. Survival difference between Toronto and Detroit has been found due to structural differences in health care delivery in the states.
KW  - CANCER
KW  - SOCIAL status
KW  - HEALTH
KW  - MEDICAL care -- Finance
KW  - SOCIAL factors
KW  - U.S. states
KW  - UNITED States
N1  - Accession Number: 9708130597; Schatzkin, Arthur 1; Affiliation:  1: National Cancer Institute, Bethesda; Source Info: Jul97, Vol. 87 Issue 7, p1095; Subject Term: CANCER; Subject Term: SOCIAL status; Subject Term: HEALTH; Subject Term: MEDICAL care -- Finance; Subject Term: SOCIAL factors; Subject Term: U.S. states; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1170
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Heck, Katherine E.
AU  - Wagener, Diane K.
AU  - Schatzkin, Arthur
AU  - Devesa, Susan S.
AU  - Breen, Nancy
T1  - Socioecomomic Status and Breast Cancer Mortality, 1989 through 1993: An Analysis of Education Data From Death Certificates.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/07//
VL  - 87
IS  - 7
M3  - Article
SP  - 1218
EP  - 1222
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined whether more highly educated women were at greater risk of dying of breast cancer during 1989 through 1993. Methods. Breast cancer mortality rates were calculated through death certificates and Current Population Survey data. Results. Breast cancer mortality rates were highest among women with 12 and with 16 or more years of education. Non-Hispanic Black women had the highest mortality rates and Asian women the lowest. Positive relationships between mortality and education were found for Hispanic women as well as non-Hispanic Black and Asian women. Conclusions. The previously seen positive relationship between breast cancer mortality and education was found among US women of color but not non-Hispanic White women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL status
KW  - BREAST cancer
KW  - CANCER in women
KW  - CANCER -- Mortality
KW  - EDUCATION
KW  - DEATH certificates
KW  - WHITE women
KW  - AFRICAN American women
N1  - Accession Number: 9708130622; Heck, Katherine E. 1 Wagener, Diane K. 1 Schatzkin, Arthur 2 Devesa, Susan S. 2 Breen, Nancy 2; Affiliation:  1: National Center for Health Statistics, Hyattsville, Md  2: National Cancer Institute, Bethesda, Md; Source Info: Jul97, Vol. 87 Issue 7, p1218; Subject Term: SOCIAL status; Subject Term: BREAST cancer; Subject Term: CANCER in women; Subject Term: CANCER -- Mortality; Subject Term: EDUCATION; Subject Term: DEATH certificates; Subject Term: WHITE women; Subject Term: AFRICAN American women; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 4001
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107251786
T1  - Annotation: disparity in cancer survival and alternative health care financing systems... An international comparison of cancer survival: Toronto, Ontario, and Detroit, Michigan, metropolitan areas.
AU  - Schatzkin A
Y1  - 1997/07//
N1  - Accession Number: 107251786. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074. 
KW  - Neoplasms -- Mortality
KW  - Socioeconomic Factors
KW  - Health Care Delivery -- United States
KW  - Health Care Delivery -- Canada
KW  - Outcomes (Health Care)
KW  - United States
KW  - Canada
SP  - 1095
EP  - 1096
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 87
IS  - 7
CY  - Washington, District of Columbia
PB  - American Public Health Association
SN  - 0090-0036
AD  - National Cancer Institute, Bethesda, MD
U2  - PMID: 9240093.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107251786&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107253135
T1  - Heterocyclic amines, cytochrome P4501A2, and N-acetyltransferase: issues involved in incorporating putative genetic susceptibility markers into epidemiological studies.
AU  - Sinha R
AU  - Caporaso N
Y1  - 1997/07//1997 Jul
N1  - Accession Number: 107253135. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Amines -- Metabolism
KW  - Carcinogens
KW  - Enzymes -- Metabolism
KW  - Genetics, Medical
KW  - Epidemiological Research
KW  - Experimental Studies
KW  - Microbiological Techniques
KW  - Pearson's Correlation Coefficient
KW  - Logistic Regression
KW  - Metabolism
KW  - Genetic Techniques
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 350
EP  - 356
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 7
IS  - 5
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: Heterocyclic amines (HCAs), which are found mainly in well-cooked meat, require metabolic activation to function as mutagens and animal carcinogens. Enzymes such as cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) perform this task and are subject to interindividual variation. The source of this variation may be genetic, as in the case of NAT2, or both genetic and environmental as with CYP1A2. The present study examined the effect of HCAs on the NAT2 and CYP1A2 phenotypes in 33 males and 33 females. METHODS: The subjects consumed a low HCA-containing diet for 1 week followed by a high HCA diet for the subsequent week. The subjects were phenotyped for CYP1A2 and NAT2 at the time of entry into the study (free-living), 1 week later (end of low-HCA or low-induction diet) and 2 weeks later (end of high-HCA or high-induction diet). RESULTS: Consistent with genetic sources of variability, NAT2 showed little effect of a high-HCA diet and exhibited high intraindividual correlation. CYP1A2, in contrast, was induced by a high-HCA diet and exhibited a more modest intraindividual correlation. CONCLUSIONS: Incorporating putative genetic susceptibility makers in population studies requires consideration of issues of induction and inhibition of metabolizing enzymes, and effects of covariates.
SN  - 1047-2797
AD  - Division of Cancer Epidemiology, National Cancer Institute, Executive Plaza North, Rm 430, 6130 Executive Blvd, Rockville, MD 20892
U2  - PMID: 9250630.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107253135&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107182903
T1  - Drug update. Management of hormone-sensitive metastatic prostate cancer: update on hormonal therapy.
AU  - Figg WD
AU  - Feuer JA
AU  - Bauer KS
A2  - Burke MB
A2  - Ignoffo RJ
Y1  - 1997/07//1997 Jul-Aug
N1  - Accession Number: 107182903. Language: English. Entry Date: 19990501. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. Grant Information: U.S. Government. NLM UID: 9312355. 
KW  - Prostatic Neoplasms -- Drug Therapy
KW  - Hormone Therapy
KW  - Androgen Antagonists -- Therapeutic Use
KW  - Funding Source
KW  - Chemotherapy, Cancer
KW  - Glucocorticoids -- Therapeutic Use
KW  - Megestrol -- Therapeutic Use
KW  - Ketoconazole -- Therapeutic Use
KW  - Male
SP  - 258
EP  - 263
JO  - Cancer Practice
JF  - Cancer Practice
JA  - CANCER PRACT
VL  - 5
IS  - 4
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 1065-4704
AD  - Clinical Pharmacokinetics Unit, Cellular and Clinical Pharmacology Section, Developmental Therapeutics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 9250085.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107182903&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107339233
T1  - Merging a PICU and MICU: a debate.
AU  - Dominguez DC
AU  - Clarke DL
AU  - Mavroukakis SA
AU  - Coghill K
AU  - Smatlak P
Y1  - 1997/07//1997 Jul-Aug
N1  - Accession Number: 107339233. Language: English. Entry Date: 19971001. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8211489. 
KW  - Health Facility Merger
KW  - Intensive Care Units
KW  - Intensive Care Units, Pediatric
KW  - Bed Occupancy
KW  - Cost Savings
KW  - Cross Infection
SP  - 216
EP  - 223
JO  - Dimensions of Critical Care Nursing
JF  - Dimensions of Critical Care Nursing
JA  - DCCN
VL  - 16
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - One of the possible combinations when merging specialty units is combining a pediatric intensive care unit with an adult intensive care unit. The response related to the merging of these specialty units solicits very intense, diverse opinions. The authors address this controversial issue in a debate forum to present both sides of the issue.
SN  - 0730-4625
AD  - National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9248381.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107339233&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Crescenzi, Orlando
AU  - Fraternali, Franca
AU  - Picone, Delia
AU  - Tancredi, Teodorico
AU  - Balboni, Gianfranco
AU  - Guerrini, Remo
AU  - Lazarus, Lawrence H.
AU  - Salvadori, Severo
AU  - Temussi, Piero A.
T1  - Design and solution structure of a partially rigid opioid antagonist lacking the basic center: Models of antagonism.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/07//7/1/97
VL  - 247
IS  - 1
M3  - Article
SP  - 66
EP  - 73
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Reports on the design and characterization of an opioid antagonist lacking the basic nitrogen of tyramine to discriminate between two general models of antagonism.  Description of the conformational state of the diketopiperazine in terms of only three conformers whose relative populations vary widely with solvent; Proposed quantitative explanation for the discrepancy between the very high binding affinity and the fairly small in mouse vas deferens value.
KW  - OPIOIDS
KW  - TYRAMINE
KW  - DRUG antagonism
KW  - PIPERAZINE
KW  - NITROGEN
KW  - AMINES
N1  - Accession Number: 11961345; Crescenzi, Orlando 1 Fraternali, Franca 2 Picone, Delia 1 Tancredi, Teodorico 3 Balboni, Gianfranco 4 Guerrini, Remo 4 Lazarus, Lawrence H. 5 Salvadori, Severo 4 Temussi, Piero A. 1; Email Address: pat@chemna.dichi.unina.it; Affiliation:  1: Dipartimento di Chimica, Università di Napoli Federico II, Italy  2: Laboratoire MSM, Institut Le Bel, Université Louis Pasteur, France  3: Istituto Chimica MIB del CNR, Italy  4: Dipartimento di Scienze Farmaceutiche, Università de Ferrara, Italy  5: Peptide Neurochemistry, LMNI, National Institute of Environmental Health Sciences, USA; Source Info: 7/1/97, Vol. 247 Issue 1, p66; Subject Term: OPIOIDS; Subject Term: TYRAMINE; Subject Term: DRUG antagonism; Subject Term: PIPERAZINE; Subject Term: NITROGEN; Subject Term: AMINES; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 8p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11961345&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107352541
T1  - Insights. Schizophrenia: the need for early treatment.
AU  - Wyatt RJ
AU  - Henter ID
Y1  - 1997/07//
N1  - Accession Number: 107352541. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9417017. 
KW  - Schizophrenia -- Therapy
KW  - Antipsychotic Agents -- Therapeutic Use
KW  - Electroconvulsive Therapy
KW  - Time Factors
SP  - 4
EP  - 6
JO  - Harvard Mental Health Letter
JF  - Harvard Mental Health Letter
JA  - HARV MENT HEALTH LETT
VL  - 14
IS  - 1
CY  - Stamford, Connecticut
PB  - Harvard Health Publications
SN  - 1057-5022
AD  - Neuropsychiatry Branch, National Institute of Mental Health
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107352541&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107339262
T1  - A guide to noninvasive intermittent ventilatory support.
AU  - Knebel A
AU  - Allen M
AU  - McNemar A
AU  - Peterson A
AU  - Feigenbaum K
Y1  - 1997/07//1997 Jul-Aug
N1  - Accession Number: 107339262. Language: English. Entry Date: 19971001. Revision Date: 20150818. Publication Type: Journal Article; case study; pictorial; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0330057. 
KW  - Respiration, Artificial
KW  - Respiration, Artificial -- Nursing
KW  - Noninvasive Procedures
KW  - Respiratory Failure -- Therapy
KW  - Respiratory Nursing
KW  - Patient Education
KW  - Equipment Maintenance
KW  - Immunologic Deficiency Syndromes -- Complications
KW  - Adult
KW  - Female
SP  - 307
EP  - 316
JO  - Heart & Lung
JF  - Heart & Lung
JA  - HEART LUNG
VL  - 26
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
AB  - Patients who use home-based medical technologies, such as noninvasive intermittent ventilatory support, may require hospitalization on units where the staff is unfamiliar with this type of equipment. Consequently, acute care clinicians need resources so they can provide safe care to these patients. This article provides background information about noninvasive intermittent ventilatory support, presents a case study to illustrate key aspects of each type of support, and provides quick reference tables to assist acute care clinicians in managing this technology.
SN  - 0147-9563
AD  - National Institutes of Health, Clinical Center Nursing Department, Bldg. 10, Room 2C206, 10 Center Dr, MSC 1506, Bethesda, MD 20892-1506
U2  - PMID: 9257141.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107339262&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107142976
T1  - Development of outcome measures for therapeutic trials of chronic fatigue syndrome.
AU  - Spring SB
AU  - Tierney EL
AU  - Jolson HM
Y1  - 1997/07//
N1  - Accession Number: 107142976. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9442486. 
KW  - Fatigue Syndrome, Chronic
KW  - Clinical Trials
KW  - Outcomes Research
KW  - Outcome Assessment
KW  - Study Design
KW  - Prospective Studies
KW  - Intervention Trials
KW  - Measurement Issues and Assessments
KW  - Chronic Disease
KW  - Arthritis, Rheumatoid
KW  - Fibromyalgia
KW  - Temporomandibular Joint Syndrome
KW  - Drug Approval
KW  - Health Status
KW  - Research Methodology
KW  - Treatment Outcomes
SP  - 69
EP  - 95
JO  - Journal of Chronic Fatigue Syndrome
JF  - Journal of Chronic Fatigue Syndrome
JA  - J CHRONIC FATIGUE SYNDR
VL  - 3
IS  - 3
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - 'The chronic fatigue syndrome (CFS) is a clinically defined condition characterized by severe disabling fatigue and a combination of symptoms that prominently feature self-reported impairments in concentration and short-term memory, sleep disturbances and musculoskeletal pain' (1). The variability of the course and severity of CFS combined with the slow and infrequent full recovery and the lack of a defined aetiology have complicated the implementation of therapeutic clinical trials. The goal of the workshop was to begin a systematic consideration of clinical trials issues and outcome measures that could be used to evaluate CFS therapies in a definitive manner for safety and efficacy. The focus of the workshop was on common issues applicable across therapies rather than on the merits of individual therapies Careful study design is critical to all trials. New methods and measures of health status will aid in determining the extent of change related to therapeutic interventions. Approaches and methods used in the study and therapy of other chronic illnesses may provide important insights for designing clinical trials and choosing outcome measures for CFS interventions. Short-term outcomes in small groups of patients need to be validated by other research groups, by additional and even larger studies, and by long-term studies. To ensure enrollment and compliance, patient concerns need to be considered in study design.
SN  - 1057-3321
AD  - Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Bldg, Room 3A-15, MSC-7630, Bethesda, MD 20892-7630
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107142976&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107337957
T1  - Low-dose urokinase infusions to treat fibrinous obstruction of venous access devices in cancer patients.
AU  - Horne MK III
AU  - Mayo DJ
AU  - Horne, M K 3rd
AU  - Mayo, D J
Y1  - 1997/07//
N1  - Accession Number: 107337957. Language: English. Entry Date: 19970901. Revision Date: 20161120. Publication Type: journal article; pictorial; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Vascular Access Devices
KW  - Catheter Occlusion
KW  - Urokinase -- Therapeutic Use
KW  - Heparin -- Therapeutic Use
KW  - Drug Therapy, Combination
KW  - Treatment Outcomes
KW  - Urokinase -- Administration and Dosage
KW  - Prospective Studies
KW  - Kaplan-Meier Estimator
KW  - Data Analysis Software
KW  - Fisher's Exact Test
KW  - Mann-Whitney U Test
KW  - Wilcoxon Signed Rank Test
KW  - Linear Regression
KW  - Human
SP  - 2709
EP  - 2714
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: This study was undertaken to determine the role of low-dose urokinase infusions in treating fibrinous occlusions of venous access devices (VADs) in cancer patients.Patients and Methods: Forty-two patients with VAD occlusions refractory to routine urokinase instillations were documented by x-ray (cathetergram) to have fibrin sleeves at the catheter tips. They were randomized to receive infusions of either urokinase (40,000 U/h) or urokinase with heparin (320 U/h) through their catheters. After 1, 3, 6, and 12 hours of treatment, the function of the VADs was reassessed. Whenever the obstruction had been relieved, the infusion was stopped and a repeat cathetergram was performed. The status of the unoccluded catheters was followed to determine the longevity of the restored function.Results: Twenty-one catheters were treated with urokinase alone and 21 with the combination of urokinase and heparin. In each group, 16 VADs opened within 12 hours of treatment and five did not. By actuarial analysis, the probability was only 0.28 that a reopened catheter would reocclude within 6 months.Conclusion: Low-dose urokinase infusions can restore function to the majority of catheters occluded by fibrin sleeves. Adding heparin to the urokinase does not enhance the efficacy of the infusions. The restored function often persists until the VADs are removed.
SN  - 0732-183X
AD  - Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
AD  - Room 2C390, Building 10, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892. Email: mhorne@nih.gov
U2  - PMID: 9215844.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107337957&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88840186
T1  - Role of independent data-monitoring committees in randomized clinical trials sponsored by the National Cancer Institute.
AU  - Smith, Malcolm A.
AU  - Ungerleider, Richard S.
AU  - Korn, Edward L.
AU  - Rubinstein, Lawrence
AU  - Simon, Richard
AU  - Smith, M A
AU  - Ungerleider, R S
AU  - Korn, E L
AU  - Rubinstein, L
AU  - Simon, R
Y1  - 1997/07//
N1  - Accession Number: 88840186. Language: English. Entry Date: 19970901. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). NLM UID: 8309333. 
KW  - Clinical Trials -- Standards
KW  - Professional Practice -- Standards
KW  - National Institutes of Health (U.S.)
KW  - United States
KW  - Scales
SP  - 2736
EP  - 2743
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To describe the rationale for independent data monitoring committees (DMCs) for National Cancer Institute (NCI)-sponsored phase III cooperative group clinical trials.Design: We review the necessity for interim monitoring of outcome data during the course of randomized clinical trials and summarize the reasons for establishing DMCs with requisite expertise and with appropriate independence from study investigators.Results: The important components of the policy for cooperative group DMCs are described with a focus on the makeup of these bodies and on the complementary roles of study committee leadership and DMCs in protecting patient safety during the conduct of randomized clinical trials.Conclusion: The cooperative group DMCs that are independent of the study committees and that have the requisite expertise to examine accumulating data and to base decisions on monitoring guidelines that are specified in advance by the study committee provide a body able to protect patient safety, to protect the integrity of the clinical experiments on which patients have consented to participate, and to assure the public that conflicts of interest do not compromise either patient safety or trial integrity.
SN  - 0732-183X
AD  - Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD
AD  - Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA
U2  - PMID: 9215848.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=88840186&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sander, Christian A.
AU  - Kind, Peter
AU  - Kaudewitz, Peter
AU  - Raffeld, Mark
AU  - Jaffe, Elaine S.
T1  - The Revised European-American Classification of Lymphoid Neoplasms (REAL): a new perspective for the classification of cutaneous lymphomas.
JO  - Journal of Cutaneous Pathology
JF  - Journal of Cutaneous Pathology
Y1  - 1997/07//
VL  - 24
IS  - 6
M3  - Article
SP  - 329
EP  - 341
SN  - 03036987
AB  - Differing classification schemes for malignant lymphomas have been used in Europe and the United States. Attempts to translate between the principle classifications have been unsuccessful and historically it has been difficult to arrive at an unified approach. In addition, many new lymphoma entities have been recognized in recent years that are not delineated in any of the existing classification schemes.  To provide a unified international basis for clinical and investigative work in this field, in 1994 the International Lymphoma Study Group (ILSG) proposed a new classification termed Revised European-American Classification of Lymphoid Neoplasms (RE- AL). This review discusses the REAL classification, especially as it pertains to cutaneous lymphomas, and provides insight into the clinicopathologic features of lymphoproliferative disease involving the skin.  The premise of the REAL classification is that a classification scheme should be based on the delineation of disease entities, utilizing pathologic, immunophenotypic, genetic, and clinical features. Therefore, if cutaneous involvement is an integral aspect of any lymphoma subtype, this clinical information is included in the definition of that neoplasm. We conclude that the principles of the REAL classification are applicable to cutaneous lymphomas, as well as lymphomas involving other anatomic sites. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LYMPHOMAS
KW  - CANCER
KW  - TUMORS
KW  - SKIN
KW  - EUROPE
KW  - UNITED States
N1  - Accession Number: 11871693; Sander, Christian A. 1 Kind, Peter 1 Kaudewitz, Peter 1 Raffeld, Mark 2 Jaffe, Elaine S. 2; Affiliation:  1: Department of Dermatology, Ludwig-Maximillians- Universitaet, Munich, Germany.  2: Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jul97, Vol. 24 Issue 6, p329; Subject Term: LYMPHOMAS; Subject Term: CANCER; Subject Term: TUMORS; Subject Term: SKIN; Subject Term: EUROPE; Subject Term: UNITED States; Number of Pages: 13p; Document Type: Article
L3  - 10.1111/1600-0560.ep11871693
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11871693&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Jonas, Wayne B.
T1  - Alternative medicine.
JO  - Journal of Family Practice
JF  - Journal of Family Practice
Y1  - 1997/07//
VL  - 45
IS  - 1
M3  - Editorial
SP  - 34
EP  - 37
SN  - 00943509
AB  - This article discusses the general concepts of complementary and alternative medicine (CAM). The themes dealt with by CAM are themes that cut across all medical specialties, from molecular biology to preventive and primary health care. CAM is defined as those practices used for the prevention and treatment of disease that are not taught widely in medical schools, nor generally available inside hospitals. The first step is to learn the general concepts of CAM with the goal of being able to differentiate one type of practice from another, especially in regard to safety.
KW  - ALTERNATIVE medicine
KW  - MOLECULAR biology
KW  - PRIMARY health care
KW  - PREVENTIVE medicine
KW  - THERAPEUTICS
KW  - MEDICAL care
N1  - Accession Number: 9708315816; Jonas, Wayne B. 1; Affiliation:  1: Office of Alternative Medicine, National Institutes of Health, Washington, DC; Source Info: Jul1997, Vol. 45 Issue 1, p34; Subject Term: ALTERNATIVE medicine; Subject Term: MOLECULAR biology; Subject Term: PRIMARY health care; Subject Term: PREVENTIVE medicine; Subject Term: THERAPEUTICS; Subject Term: MEDICAL care; Number of Pages: 4p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107350477
T1  - The Eating Behavior Scale: a simple method of assessing functional ability in patients with Alzheimer's disease.
AU  - Tully MW
AU  - Matrakas KL
AU  - Muir J
AU  - Musallam K
Y1  - 1997/07//1997 Jul
N1  - Accession Number: 107350477. Language: English. Entry Date: 19971201. Revision Date: 20150818. Publication Type: Journal Article; forms; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al); Raven Colored Progressive Matrices; Mattis Dementia Scale (MDS). NLM UID: 7510258. 
KW  - Eating Behavior -- Evaluation
KW  - Functional Assessment
KW  - Alzheimer's Disease
KW  - Instrument Validation
KW  - Validation Studies
KW  - Convenience Sample
KW  - Psychological Tests
KW  - Observational Methods
KW  - Interrater Reliability
KW  - Content Validity
KW  - Correlation Coefficient
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Inpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 9
EP  - 55
JO  - Journal of Gerontological Nursing
JF  - Journal of Gerontological Nursing
JA  - J GERONTOL NURS
VL  - 23
IS  - 7
CY  - Thorofare, New Jersey
PB  - SLACK Incorporated
AB  - Caregivers of patients with AD frequently exhibit unrealistic expectations related to a patient's functional ability during eating. Eating is a complex task that requires planning, attention, initiation, conceptualization and visuospatial abilities. The EBS tool helps a caregiver identify the patient's current ability to eat. The EBS is a simple functional assessment tool that does not rely on patient compliance for use.
SN  - 0098-9134
AD  - National Institutes of Health Clinical Center Nursing Dept, 9000 Rockville Pike, Bldg 10, 7D-55, Bethesda, MD 20892-1592
U2  - PMID: 9287601.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - De Laurenzi, Vincenzo
AU  - Rogers, Geraldine R.
AU  - Tarcsa, Edit
AU  - Carney, Gael
AU  - Marekov, Lyuben
AU  - Bale, Sherri J.
AU  - Compton, John G.
AU  - Markova, Nelli
AU  - Steinert, Peter M.
AU  - Rizzo, William B.
T1  - Sjögren-Larsson Syndrome Is Caused by a Common Mutation in Northern European and Swedish Patients.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/07//
VL  - 109
IS  - 1
M3  - Article
SP  - 79
EP  - 83
SN  - 0022202X
AB  - Sjögren-Larsson syndrome (SLS) is an autosomal recessive disorder characterized by congenital ichthyosis, mental retardation, and spastic diplegia or tetraplegia. Patients with SLS have deficient activity of fatty aldehyde dehydrogenase (FALDH), an enzyme involved in long-chain fatty alcohol oxidation. The cDNA encoding FALDH has recently been cloned and several different mutations have been found in SLS patients. We have now identified a point mutation (C943 → T) in 7 of 19 kindreds of European descent, accounting for 24% of the SLS alleles. The C943T mutation was only found in patients of northern European ancestry from Sweden, the Netherlands, Germany, and Belgium. Haplotype analysis suggested that the patients carrying the C943T allele were distantly related. All four Swedish patients were homozygous for C943T, indicating that this mutation is probably the major cause of SLS in the inbred Swedish families. The mutation leads to the substitution of serine for the highly conserved proline 315 in the FALDH protein, and expression studies confirm that it destroys enzymatic activity. The mutation was readily detected with an <em>Mnl</em>I restriction enzyme digestion test. The finding that C943T is a common SLS mutation in northern European and Swedish patients affords a rapid simple method for diagnosing SLS by screening patients for this mutation with DNA-based methods. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ICHTHYOSIS
KW  - MENTAL disabilities
KW  - SPASTICITY
KW  - ALDEHYDE dehydrogenase
KW  - MUTATION (Biology)
KW  - ENZYMES
KW  - aldehyde dehydrogenase
KW  - ichthyosis
KW  - mental retardation
KW  - spasticity
N1  - Accession Number: 12276622; De Laurenzi, Vincenzo Rogers, Geraldine R. 1 Tarcsa, Edit 1 Carney, Gael Marekov, Lyuben 1 Bale, Sherri J. 1 Compton, John G. 1 Markova, Nelli 1 Steinert, Peter M. 1 Rizzo, William B. 2; Affiliation:  1: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Departments of Pediatrics and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, U.S.A.; Source Info: Jul97, Vol. 109 Issue 1, p79; Subject Term: ICHTHYOSIS; Subject Term: MENTAL disabilities; Subject Term: SPASTICITY; Subject Term: ALDEHYDE dehydrogenase; Subject Term: MUTATION (Biology); Subject Term: ENZYMES; Author-Supplied Keyword: aldehyde dehydrogenase; Author-Supplied Keyword: ichthyosis; Author-Supplied Keyword: mental retardation; Author-Supplied Keyword: spasticity; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12276622
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12276622&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yang, Jun-Mo
AU  - Lee, Seewoo
AU  - Bang, Hyeong-Don
AU  - Kim, Won-Serk
AU  - Lee, Eil-Soo
AU  - Steinert, Peter M.
T1  - A Novel Threonine → Proline Mutation at the End of 2B Rod Domain in the Keratin 2e Chain in Ichthyosis Bullosa of Siemens.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/07//
VL  - 109
IS  - 1
M3  - Article
SP  - 116
EP  - 119
SN  - 0022202X
AB  - We report a novel mutation in a case of ichthyosis bullosa of Siemens that results in a threonine → proline substitution in a novel location, codon 485 in a highly conserved residue position of the IAT- YRKLLEGE consensus motif at the end of the 2B rod domain segment of the keratin 2e chain. The disease phenotype is consistent with the inappropriate substitution of a proline near the end of the rod domain, because it lies near the predicted molecular overlap region of coiled-coil molecules, which is critical for the maintenance of the structural integrity of keratin intermediate filaments. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ICHTHYOSIS
KW  - KERATIN
KW  - PROLINE
KW  - CYTOPLASMIC filaments
KW  - PHENOTYPE
KW  - KERATOSIS
N1  - Accession Number: 12276775; Yang, Jun-Mo 1,2 Lee, Seewoo 2 Bang, Hyeong-Don 3 Kim, Won-Serk 1 Lee, Eil-Soo 1 Steinert, Peter M. 4; Affiliation:  1: Department of Dermatology, College of Medicine, Sungkyunkwan University, Seoul, Republic of Korea  2: Clinical and Basic Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea  3: Department of Dermatology, College of Medicine, Seoul National University, Seoul, Republic of Korea  4: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul97, Vol. 109 Issue 1, p116; Subject Term: ICHTHYOSIS; Subject Term: KERATIN; Subject Term: PROLINE; Subject Term: CYTOPLASMIC filaments; Subject Term: PHENOTYPE; Subject Term: KERATOSIS; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12276775
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12276775&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Brown, Linda Morris
AU  - Gridley, Gloria
AU  - Olsen, J⊘rgen H.
AU  - Mellemkjær, Lene
AU  - Linet, Martha S.
AU  - Fraumeni Jr, Joseph F.
T1  - Cancer Risk and Mortality Patterns Among Silicotic Men in Sweden and Denmark.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1997/07//
M3  - Article
SP  - 633
EP  - 638
SN  - 00961736
AB  - Data from nationwide registry-based cohorts of patients hospitalized for silicosis in Sweden from 1965 to 1983 and Denmark from 1977 to 1989 were linked to national cancer registries in both countries and to mortality data in Sweden to evaluate the risk of cancer and other disorders among hospitalized silicotic patients. The overall cancer standardized incidence ratio (SIR) was 1.5 (95% confidence interval [CI], 1.3 to 1.7) in Sweden and 1.7(95% CI, 1.2 to 2.3) in Denmark, primarily because of elevations in primary lung cancer in both Sweden (SIR, 3.1; CI, 2.1 to 4.2) and Denmark (SIR, 2.9; CI, 1.5 to 5.2). For Sweden, the all-causes standardized mortality ratio (SMR) was 2.0 (1.9 to 2.2). The SMR for all malignancies was 1.5 (1.2 to 1.7), primarily because of excesses of lung cancer (SMR, 2.9; CI, 2.1 to 3.9). The significant increase in mortality for all infectious and parasitic conditions (SMR, 11.2) was primarily due to tuberculosis (SMR, 21.8). Significant excesses in mortality from silicosis (SMR, 523), bronchitis (SMR, 2.6) and emphysema (SMR, 6.7) contributed to the elevation in nonmalignant respiratory deaths (SMR, 8.8), whereas excess mortality from musculoskeletal disorders (SMR, 5.9) was due to six deaths from autoimmune diseases. Despite limitations of the available data, our findings are consistent with previous reports indicating that silicotic patients are at elevated risk of lung cancer, nonmalignant respiratory diseases, tuberculosis, and certain autoimmune disorders. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 113379260; Brown, Linda Morris 1 Gridley, Gloria 1 Olsen, J⊘rgen H. 1 Mellemkjær, Lene 1 Linet, Martha S. 1 Fraumeni Jr, Joseph F. 1; Affiliation:  1: From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md. (Ms Brown, Ms Gridley, Dr Linet, Dr Fraumeni); and the Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen, Denmark (Dr Olsen, Ms Mellemkjær).; Source Info: Jul1997, p633; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 4160
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107203263
T1  - Safety of a fat-reduced diet: the Dietary Intervention Study in Children (DISC)
AU  - Obarzanek E
AU  - Hunsberger SA
AU  - Van Horn L
AU  - Hartmuller VV
AU  - Barton BA
AU  - Stevens VJ
AU  - Kwiterovich PO
AU  - Franklin FA
AU  - Kimm SYS
AU  - Lasser NL
AU  - Simons-Morton DG
AU  - Lauer RM
Y1  - 1997/07//
N1  - Accession Number: 107203263. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by the National Heart, Lung, and Blood Institute cooperative agreements HL-37947, HL-37948, HL-37954, HL-37962, HL-37966, HL-37975, and HL-38110. NLM UID: 0376422. 
KW  - Diet, Fat-Restricted -- In Infancy and Childhood
KW  - Diet -- Evaluation
KW  - Dietary Fats -- Administration and Dosage
KW  - Energy Intake
KW  - Body Weights and Measures
KW  - Safety
KW  - Nutritional Status
KW  - Diet
KW  - Lipoproteins, LDL Cholesterol
KW  - Micronutrients
KW  - Intervention Trials
KW  - Random Assignment
KW  - Single-Blind Studies
KW  - Descriptive Statistics
KW  - Child
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 51
EP  - 59
JO  - Pediatrics
JF  - Pediatrics
JA  - PEDIATRICS
VL  - 100
IS  - 1
CY  - Chicago, Illinois
PB  - American Academy of Pediatrics
SN  - 0031-4005
AD  - National Heart, Lung, and Blood Institute, Two Rockledge Centre, Room 8136, 6701 Rockledge Dr., MSC 7936, Bethesda, MD 20892-7936
U2  - PMID: 9200359.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107203263&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107339877
T1  - The big picture on NIH PTs... April 1997 issue, 'On board at the NIH'.
AU  - McGarvey CL
Y1  - 1997/07//1997 Jul
N1  - Accession Number: 107339877. Language: English. Entry Date: 19971001. Revision Date: 20150711. Publication Type: Journal Article; commentary; letter. Journal Subset: Allied Health; USA. NLM UID: 9305738. 
KW  - National Institutes of Health (U.S.)
KW  - Research, Physical Therapy
SP  - 10
EP  - 11
JO  - PT: Magazine of Physical Therapy
JF  - PT: Magazine of Physical Therapy
JA  - PT MAG PHYS THER
VL  - 5
IS  - 7
CY  - Alexandria, Virginia
PB  - American Physical Therapy Association
SN  - 1065-5077
AD  - Warren G Magnuson Clinical Center, Bethesda, MD 301/496-2844. charles_mcgarvey@nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107339877&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105824611
T1  - Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group.
AU  - Cotch MF
AU  - Pastorek JG 2nd
AU  - Nugent RP
AU  - Hillier SL
AU  - Gibbs RS
AU  - Martin DH
AU  - Eschenbach DA
AU  - Edelman R
AU  - Carey JC
AU  - Regan JA
AU  - Krohn MA
AU  - Klebanoff MA
AU  - Rao AV
AU  - Rhoads GG
AU  - Cotch, M F
AU  - Pastorek, J G 2nd
AU  - Nugent, R P
AU  - Hillier, S L
AU  - Gibbs, R S
AU  - Martin, D H
Y1  - 1997/07//
N1  - Accession Number: 105824611. Language: English. Entry Date: 20080307. Revision Date: 20161118. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Z99 EY999999//Intramural NIH HHS/United States. NLM UID: 7705941. 
KW  - Birth Weight
KW  - Labor, Premature -- Etiology
KW  - Pregnancy Complications, Parasitic
KW  - Trichomonas Vaginitis -- Complications
KW  - Adult
KW  - Female
KW  - Infant, Low Birth Weight
KW  - Infant, Newborn
KW  - Pregnancy
KW  - Prospective Studies
KW  - Human
SP  - 353
EP  - 360
JO  - Sexually Transmitted Diseases
JF  - Sexually Transmitted Diseases
JA  - SEX TRANSM DIS
VL  - 24
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Background: Several studies have suggested that pregnant women infected with Trichomonas vaginalis may be at increased risk of an adverse outcome.Goal: To evaluate prospectively the association between T. vaginalis and risk of adverse pregnancy outcome in a large cohort of ethnically diverse women.Study Design: At University-affiliated hospitals and antepartum clinics in five United States cities, 13,816 women (5,241 black, 4,226 Hispanic, and 4,349 white women) were enrolled at mid-gestation, tested for T. vaginalis by culture, and followed up until delivery.Results: The prevalence of T. vaginalis infection at enrollment was 12.6%. Race-specific prevalence rates were 22.8% for black, 6.6% for Hispanic, and 6.1% for white women. After multivariate analysis, vaginal infection with T. vaginalis at mid-gestation was significantly associated with low birth weight (odds ratio 1.3; 95% confidence interval 1.1 to 1.5), preterm delivery (odds ratio 1.3; 95% confidence interval 1.1 to 1.4), and preterm delivery of a low birth weight infant (odds ratio 1.4; 95% confidence interval 1.1 to 1.6). The attributable risk of T. vaginalis infection associated with low birth weight weight in blacks was 11% compared with 1.6% in Hispanics and 1.5% in whites.Conclusions: After considering other recognized risk factors including co-infections, pregnant women infected with T. vaginalis at mid-gestation were statistically significantly more likely to have a low birth weight infant, to deliver preterm, and to have a preterm low birth weight infant. Compared with whites and Hispanics, T. vaginalis infection accounts for a disproportionately larger share of the low birth weight rate in blacks.
SN  - 0148-5717
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
U2  - PMID: 9243743.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00283-002
AN  - 2006-00283-002
AU  - Courtney, S. M.
AU  - Ungerleider, L. G.
AU  - Haxby, J. V.
T1  - Response from Courtney, Ungerleider and Haxby.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1997/07//
VL  - 1
IS  - 4
SP  - 125
EP  - 126
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Courtney, S. M., Laboratory of Brain and Cognition, National Institutes of Health Bethesda, 10 Center Drive, 10/4C104, MSC 1366, Bethesda, MD, US, 20892-1366
N1  - Accession Number: 2006-00283-002. PMID: 21223877 Partial author list: First Author & Affiliation: Courtney, S. M.; Laboratory of Brain and Cognition, National Institutes of Health Bethesda, Bethesda, MD, US. Release Date: 20061204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Frontal Lobe; Magnetic Resonance Imaging; Prefrontal Cortex; Short Term Memory; Visual Memory. Classification: Electrophysiology (2530). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jul, 1997. 
AB  - Reply by the current author to the comments made by Adrian M. Owen (see record [rid]2006-00283-001[/rid]) on the original article (see record [rid]1997-03801-006[/rid]). Owen poses a contrast between two views of the functional organization of prefrontal cortical areas that participate in working memory, namely that between domain and processing specificity. He finds support for functional dissociations based on processing specificity but not for dissociations based on domain specificity. By contrast, we find support for both domain and processing specificity in human prefrontal cortex. Owen's argument against domain specificity hinges on the the fact that spatial, visual, and verbal working memory tasks all activate the middorsolateral frontal cortex. His analysis of the existing literature on working memory lumps together studies in which the comparison tasks vary widely. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neural activity
KW  - perceptual cortical roles
KW  - visual working memory
KW  - mnemonic cortical roles
KW  - prefontal cortical areas
KW  - domain specificity
KW  - 1997
KW  - Frontal Lobe
KW  - Magnetic Resonance Imaging
KW  - Prefrontal Cortex
KW  - Short Term Memory
KW  - Visual Memory
KW  - 1997
DO  - 10.1016/S1364-6613(97)01048-6
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00283-002&site=ehost-live&scope=site
UR  - susan_courtney@alw.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09772-001
AN  - 2008-09772-001
AU  - Loughrey, Kathleen A.
AU  - Balch, George I.
AU  - Lefebvre, R. Craig
AU  - Doner, Lynne
AU  - Johnston, Cecile
AU  - Eisner, Ellen
AU  - Hadley, Linda
T1  - Bringing 5 a day consumers into focus: Qualitative use of consumer research to guide strategic decision making.
JF  - Journal of Nutrition Education
JO  - Journal of Nutrition Education
JA  - J Nutr Educ
Y1  - 1997/07//
VL  - 29
IS  - 4
SP  - 172
EP  - 177
CY  - Canada
PB  - BC Decker
SN  - 0022-3182
AD  - Loughrey, Kathleen A., USDA, Center for Nutrition Policy and Promotion, 1120 20th Street, NW, Suite 200, North Lobby, Washington, DC, US, 20036
N1  - Accession Number: 2008-09772-001. Other Journal Title: Journal of Nutrition Education and Behavior. Partial author list: First Author & Affiliation: Loughrey, Kathleen A.; United States Department of Agriculture, Washington, DC, US. Other Publishers: Elsevier Science. Release Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consumer Research; Eating Behavior; Health Promotion; Qualitative Research; Social Marketing. Minor Descriptor: Communication; Consumer Behavior; Food; Health Education; Nutrition. Classification: Promotion & Maintenance of Health & Wellness (3365); Consumer Psychology (3900). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 1997. 
AB  - As part of the national 5 A Day for Better Health program, a communication strategy based on a social marketing model was developed to guide the program's media campaign. Using this approach, the campaign focused on consumer wants and needs to help increase the prospects of influencing consumer behavior. The work discussed herein describes how consumer research was used to select and profile a target audience for the national 5 A Day media campaign. It shows how formative consumer research data from multiple sources were integrated to make practical strategic campaign decisions based on the target consumer's perspective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - 5 A Day for Better Health program
KW  - media communication strategy
KW  - social marketing
KW  - qualitative consumer research
KW  - fruit vegetable consumption
KW  - 1997
KW  - Consumer Research
KW  - Eating Behavior
KW  - Health Promotion
KW  - Qualitative Research
KW  - Social Marketing
KW  - Communication
KW  - Consumer Behavior
KW  - Food
KW  - Health Education
KW  - Nutrition
KW  - 1997
DO  - 10.1016/S0022-3182(97)70194-8
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09772-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09772-002
AN  - 2008-09772-002
AU  - Balch, George I.
AU  - Loughrey, Kathleen
AU  - Weinberg, Linda
AU  - Lurie, Deborah
AU  - Eisner, Ellen
T1  - Probing consumer benefits and barriers for the National 5 A Day Campaign: Focus group findings.
JF  - Journal of Nutrition Education
JO  - Journal of Nutrition Education
JA  - J Nutr Educ
Y1  - 1997/07//
VL  - 29
IS  - 4
SP  - 178
EP  - 183
CY  - Canada
PB  - BC Decker
SN  - 0022-3182
AD  - Balch, George I., Prevention Research Center, University of Illinois-Chicago, 850 W. Jackson Boulevard, Chicago, IL, US, 60607
N1  - Accession Number: 2008-09772-002. Other Journal Title: Journal of Nutrition Education and Behavior. Partial author list: First Author & Affiliation: Balch, George I.; Prevention Research Center, Chicago, IL, US. Other Publishers: Elsevier Science. Release Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consumer Attitudes; Consumer Research; Health Promotion; Nutrition; Qualitative Research. Minor Descriptor: Consumer Behavior; Diets; Health Behavior; Social Marketing. Classification: Promotion & Maintenance of Health & Wellness (3365); Consumer Psychology (3900). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Interview; Focus Group; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 1997. 
AB  - This research identifies benefits that target consumers from the national 5 A Day for Better Health media program find motivating, as well as barriers that these benefits must overcome. Conventional and 'piggyback' focus groups were conducted with the target audience and with a comparison group (people who already eat five or more servings a day of fruits and vegetables). Consistent with prior research, target group participants saw little urgency to eating more fruits and vegetables and were not very involved with food planning. Benefits that seemed likely to encourage more consumption of fruits and vegetables were immediate benefits—such as feeling more energetic—rather than long-term benefits related to reducing health risks. Target consumers rejected as implausible or irrelevant other benefits that strategists had considered appropriate: feeling less stress and more in control and reducing one's risk of cancer. The target audience saw barriers of time and inconvenience in the 'normal steps' in the comparison group's routine. Results have been used to develop communications. The findings suggest that nutrition educators should use messages with immediate consumer benefits and, consistent with prior research and theory, should offer 'quick and easy' tips for consumers to attain the desired health-related behavior. The findings also underscore the importance of direct consumer research to ensure that program messages and strategies are relevant to the target audience. The study also illustrates the utility of piggyback groups to clarify differences and similarities between target and comparison segments and to assess how, if at all, comparison segments can effectively model desired consumer behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - consumer benefits
KW  - consumer barriers
KW  - National 5 A Day Campaign
KW  - focus groups
KW  - 1997
KW  - Consumer Attitudes
KW  - Consumer Research
KW  - Health Promotion
KW  - Nutrition
KW  - Qualitative Research
KW  - Consumer Behavior
KW  - Diets
KW  - Health Behavior
KW  - Social Marketing
KW  - 1997
DO  - 10.1016/S0022-3182(97)70195-X
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09772-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-11586-005
AN  - 2005-11586-005
AU  - Williams, David R.
AU  - Yu, Yan
AU  - Jackson, James S.
AU  - Anderson, Norman B.
T1  - Racial Differences in Physical and Mental Health: Socio-economic Status, Stress and Discrimination.
T3  - Health and socio-economic position
JF  - Journal of Health Psychology
JO  - Journal of Health Psychology
JA  - J Health Psychol
Y1  - 1997/07//
VL  - 2
IS  - 3
SP  - 335
EP  - 351
CY  - US
PB  - Sage Publications
SN  - 1359-1053
SN  - 1461-7277
AD  - Williams, David R., Institute for Social Research, University of Michigan, P.O. Box 1248, Ann Arbor, MI, US, 48106-1248
N1  - Accession Number: 2005-11586-005. PMID: 22013026 Partial author list: First Author & Affiliation: Williams, David R.; University of Michigan, Ann Arbor, MI, US. Release Date: 20060103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Mental Health; Race and Ethnic Discrimination; Socioeconomic Status; Stress. Minor Descriptor: Blacks; Discrimination; Family Socioeconomic Level; Racial and Ethnic Differences; Risk Factors; Social Class; Whites. Classification: Health Psychology & Medicine (3360); Social Processes & Social Issues (2900). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Jul, 1997. 
AB  - This article examines the extent to which racial differences in socio-economic status (SES), social class and acute and chronic indicators of perceived discrimination, as well as general measures of stress can account for black-white differences in self-reported measures of physical and mental health. The observed racial differences in health were markedly reduced when adjusted for education and especially income. However, both perceived discrimination and more traditional measures of stress are related to health and play an incremental role in accounting for differences between the races in health status. These findings underscore the need for research efforts to identify the complex ways in which economic and non-economic forms of discrimination relate to each other and combine with socio-economic position and other risk factors and resources to affect health. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - socioeconomic status
KW  - mental health
KW  - health status
KW  - racial differences
KW  - physical health
KW  - social class
KW  - risk factors
KW  - stress
KW  - discrimination
KW  - Blacks
KW  - Whites
KW  - 1997
KW  - Health
KW  - Mental Health
KW  - Race and Ethnic Discrimination
KW  - Socioeconomic Status
KW  - Stress
KW  - Blacks
KW  - Discrimination
KW  - Family Socioeconomic Level
KW  - Racial and Ethnic Differences
KW  - Risk Factors
KW  - Social Class
KW  - Whites
KW  - 1997
DO  - 10.1177/135910539700200305
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11586-005&site=ehost-live&scope=site
UR  - wildavid@umich.edu
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39705-001
AN  - 2015-39705-001
AU  - Nirenberg, Melissa J.
AU  - Chan, June
AU  - Vaughan, Roxanne A.
AU  - Uhl, George R.
AU  - Kuhar, Michael J.
AU  - Pickel, Virginia M.
T1  - Immunogold localization of the dopamine transporter: An ultrastructural study of the rat ventral tegmental area.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/07//
VL  - 17
IS  - 14
SP  - 5255
EP  - 5262
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Nirenberg, Melissa J., Department of Neurology and Neuroscience, Cornell University, Medical College, 411 East 69th Street, Room KB-410, New York, NY, US, 10021
N1  - Accession Number: 2015-39705-001. PMID: 9204909 Partial author list: First Author & Affiliation: Nirenberg, Melissa J.; Department of Neurology and Neuroscience, Cornell University, Medical College, New York, NY, US. Release Date: 20160310. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Nirenberg, Melissa J. Major Descriptor: Dopamine; Neurotransmission; Tegmentum; Reuptake. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1997. Publication History: Accepted Date: Mar 13, 1997; Revised Date: Mar 11, 1997; First Submitted Date: Dec 10, 1996. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The dopamine transporter (DAT) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. DAT is also a major binding site for cocaine and other stimulants,the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. We used electron microscopy with an anti-peptide antiserum directed against the N-terminal domain of DAT to determine the subcellular localization of this transporter in the rat ventral tegmental area (VTA), the region that contains the cell bodies and dendrites of these dopaminergic neurons. We show that in the VTA, almost 95% of the DAT immunogold-labeled profiles are neuronal perikarya and dendrites, and the remainder are unmyelinated axons. Within perikarya and large proximal dendrites, almost all of the DAT immunogold particles are associated with intracellular membranes, including saccules of Golgi and cytoplasmic tubulovesicles. In contrast, within medium- to small-diameter dendrites and unmyelinated axons, most of the DAT gold particles are located on plasma membranes. In dually labeled tissue, peroxidase reaction product for the catecholamine-synthesizing enzyme tyrosine hydroxylase is present in DAT-immunoreactive profiles. These findings suggest that intermediate and distal dendrites are both the primary sites of dopamine reuptake and the principal targets of cocaine and related psychostimulants within dopaminergic neurons in the VTA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dopamine
KW  - transporter
KW  - uptake
KW  - ultrastructure
KW  - ventral tegmental area
KW  - midbrain
KW  - mesocorticolimbic
KW  - electron microscopy
KW  - immunogold
KW  - dendritic release
KW  - plasma membrane
KW  - cocaine
KW  - amphetamine
KW  - neurotoxicity
KW  - 1997
KW  - Dopamine
KW  - Neurotransmission
KW  - Tegmentum
KW  - Reuptake
KW  - Rats
KW  - 1997
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH40342. Recipients: Nirenberg, Melissa J.; Pickel, Virginia M.
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH00078. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: DA04600. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, Intramural Research Program, US. Recipients: Vaughan, Roxanne A.; Uhl, George R.
U1  - Sponsor: National Institutes of Health, US. Grant: RR00165. Recipients: Kuhar, Michael J.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39705-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39705-009
AN  - 2015-39705-009
AU  - Glass, Michelle
AU  - Felder, Christian C.
T1  - Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: Evidence for a Gs linkage to the CB1 receptor.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/07//
VL  - 17
IS  - 14
SP  - 5327
EP  - 5333
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Felder, Christian C., Research Laboratories, Eli Lilly Corporate Center, Indianapolis, IN, US, 46285
N1  - Accession Number: 2015-39705-009. PMID: 9204917 Partial author list: First Author & Affiliation: Glass, Michelle; Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20160310. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Glass, Michelle. Major Descriptor: Cannabinoids; Dopamine; Enzymes; Neural Receptors; Proteins. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jul, 1997. Publication History: Accepted Date: May 6, 1997; Revised Date: Apr 14, 1997; First Submitted Date: Jan 29, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. Within the striatum, CB1 receptors have been shown to be localized on the same neurons as Gi-coupled dopamine D2 receptors. In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. In striatal neurons in primary culture, both the CB1 receptor agonist [3-(1,1-dimethylheptyl)-11-hydroxy-Δ⁸tetrahydrocannabinol] (HU210) and the D2 receptor agonist quinpirole inhibited forskolin-stimulated cAMP accumulation when applied separately. In contrast, HU210 and quinpirole in combination augmented cAMP accumulation. This augmentation was blocked by the CB1 receptor antagonist SR141716A or the D2 antagonist sulpride. Pertussis toxin treatment of striatal neurons prevented the inhibition of cAMP accumulation by D2 receptors but unmasked a cannabinoid receptor-mediated stimulatory effect on cAMP accumulation. The cannabinoid receptor-stimulated accumulation of cAMP was blocked in a concentration-dependent manner by SR141716A, suggesting that the response was regulated through the CB1 receptor. Similar augmentation of cAMP accumulation after pertussis toxin treatment was observed in Chinese hamster ovary (CHO) cells transfected with, and stably expressing, the CB1 receptor. This stimulation of cAMP was not Ca2+-sensitive and was unaffected by a range of protein kinase inhibitors. Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a Gs-type G-protein. Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cannabinoid
KW  - G-protein
KW  - adenylate cyclase
KW  - CB1 receptor
KW  - dopamine
KW  - D2 receptor
KW  - striatum
KW  - 1997
KW  - Cannabinoids
KW  - Dopamine
KW  - Enzymes
KW  - Neural Receptors
KW  - Proteins
KW  - 1997
U1  - Sponsor: Health Research Council of New Zealand, New Zealand. Recipients: Glass, Michelle
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39705-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39705-035
AN  - 2015-39705-035
AU  - Acs, Geza
AU  - Biro, Tamas
AU  - Acs, Peter
AU  - Modarres, Shayan
AU  - Blumberg, Peter M.
T1  - Differential activation and desensitization of sensory neurons by resiniferatoxin.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/07//
VL  - 17
IS  - 14
SP  - 5622
EP  - 5628
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Blumberg, Peter M., MMTP, Building 37, Room 3A01, 37 Convent Drive MSC 4255, Bethesda, MD, US, 20892-4255
N1  - Accession Number: 2015-39705-035. PMID: 9204943 Partial author list: First Author & Affiliation: Acs, Geza; Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD, US. Release Date: 20160310. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Capsaicin; Dorsal Roots; Sensory Neurons. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jul, 1997. Publication History: Accepted Date: May 6, 1997; Revised Date: Apr 29, 1997; First Submitted Date: Feb 7, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Recently, with use of rat dorsal root ganglion (DRG) neurons we have been able to dissociate the binding affinities of vanilloids from their potencies to induce ⁴⁵Ca uptake, which suggests the existence of distinct classes of the vanilloid receptor (Acs et al., 1996). In the present study, we have demonstrated that the ultrapotent capsaicin analog resiniferatoxin (RTX) desensitized rat DRG neurons to the subsequent induction of ⁴⁵Ca uptake by capsaicin and RTX with affinity and cooperativity similar to that found for [³H]RTX binding, contrasting with a ∼10-fold weaker potency and lack of cooperativity to induce ⁴⁵Ca uptake. Likewise, the competitive antagonist capsazepine inhibited RTX-induced desensitization with potency similar to that for inhibition of specific [³H]RTX binding, whereas the potency of capsazepine was ∼10-fold higher for inhibiting RTX-inducedundefined⁴Ca uptake. Finally, the noncompetitive antagonist ruthenium red inhibited both the RTX-induced desensitization and ⁴⁵Ca uptake but showed ∼60-fold selectivity for inhibiting RTX-induced desensitization. The RTX-induced desensitization was not associated with loss of specific [³H]RTX binding, suggesting lack of gross cell toxicity. In contrast to RTX, capsaicin caused desensitization with a potency corresponding to that for ⁴⁵Ca uptake and did so in a noncooperative manner. Unlike the RTX-induced desensitization, the desensitization by capsaicin was blocked by ruthenium red only at doses that blocked ⁴⁵Ca uptake and depended on external calcium. Our findings provide further support for the existence of vanilloid receptor subtypes on DRG neurons with distinct pharmacology and distinct patterns of desensitization. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dorsal root ganglion neurons
KW  - capsaicin
KW  - resiniferatoxin
KW  - desensitization
KW  - [ 3H]RTX binding
KW  - 45Ca uptake
KW  - capsazepine
KW  - ruthenium red
KW  - pain
KW  - rat
KW  - 1997
KW  - Capsaicin
KW  - Dorsal Roots
KW  - Sensory Neurons
KW  - Rats
KW  - 1997
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39705-035&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107341318
T1  - Fat, caloric intake, and obesity: lifestyle risk factors for breast cancer... Reducing dietary fat: putting theory into practice, December 10-11, 1996, New York, NY.
AU  - Greenwald P
AU  - Sherwood K
AU  - McDonald SS
Y1  - 1997/07/02/Jul97 Supplement
N1  - Accession Number: 107341318. Language: English. Entry Date: 19971001. Revision Date: 20150819. Publication Type: Journal Article; review. Supplement Title: Jul97 Supplement. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Breast Neoplasms -- Epidemiology
KW  - Breast Neoplasms -- Etiology
KW  - Women
KW  - Dietary Fats -- Adverse Effects
KW  - Energy Intake
KW  - Life Style
KW  - Obesity -- Complications
KW  - Animal Studies
KW  - Consumer Participation
KW  - Dietary Fats -- Administration and Dosage
KW  - Energy Metabolism
KW  - Female
KW  - Meta Analysis
KW  - Nutritional Assessment
KW  - Research Methodology
KW  - Clinical Trials
KW  - Postmenopause
KW  - Risk Factors
SP  - S24
EP  - 30
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 9216564.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107341318&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107341320
T1  - Dietary fat and human obesity... Reducing dietary fat: putting theory into practice, December 10-11, 1996, New York, NY.
AU  - Ravussin E
AU  - Tataranni PA
Y1  - 1997/07/02/Jul97 Supplement
N1  - Accession Number: 107341320. Language: English. Entry Date: 19971001. Revision Date: 20150819. Publication Type: Journal Article; review. Supplement Title: Jul97 Supplement. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Dietary Fats -- Administration and Dosage
KW  - Obesity -- Etiology
KW  - Body Constitution -- Physiology
KW  - Dietary Fats -- Adverse Effects
KW  - Energy Metabolism -- Physiology
KW  - Obesity -- Epidemiology
KW  - Obesity -- Familial and Genetic
SP  - S42
EP  - 6
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Ariz
U2  - PMID: 9216566.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107341320&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107341321
T1  - Cardiovascular health risks related to overweight... Reducing dietary fat: putting theory into practice, December 10-11, 1996, New York, NY.
AU  - Ernst ND
AU  - Obarzanek E
AU  - Clark MB
AU  - Briefel RR
AU  - Brown CD
AU  - Donato K
Y1  - 1997/07/02/Jul97 Supplement
N1  - Accession Number: 107341321. Language: English. Entry Date: 19971001. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Supplement Title: Jul97 Supplement. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Cardiovascular Diseases -- Epidemiology
KW  - Obesity -- Complications
KW  - Adult
KW  - Aged
KW  - Body Mass Index
KW  - Cardiovascular Diseases -- Etiology
KW  - Dietary Fats -- Administration and Dosage
KW  - Energy Intake
KW  - Female
KW  - Survey Research
KW  - Hypercholesterolemia -- Complications
KW  - Hypercholesterolemia -- Epidemiology
KW  - Hypertension -- Complications
KW  - Hypertension -- Epidemiology
KW  - Male
KW  - Middle Age
KW  - Obesity -- Epidemiology
KW  - Prevalence
KW  - Risk Factors
KW  - United States
KW  - Human
SP  - S47
EP  - 51
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Rockledge Center II, Room 8112, MSC 7938, Bethesda, MD 20892-7938
U2  - PMID: 9216567.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107341321&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107266690
T1  - Residential exposure to magnetic fields and acute lymphoblastic leukemia in children.
AU  - Linet MS
AU  - Hatch EE
AU  - Kleinerman RA
AU  - Robison LL
AU  - Kaune WT
AU  - Friedman DR
AU  - Severson RK
AU  - Haines CM
AU  - Hartsock CT
AU  - Niwa S
AU  - Wacholder S
AU  - Tarone RE
Y1  - 1997/07/03/
N1  - Accession Number: 107266690. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by a grant from the National Cancer Institute (RO2 CA48051) and by the University of Minnesota Children's Cancer Research Fund. NLM UID: 0255562. 
KW  - Leukemia, Lymphocytic -- Etiology -- In Infancy and Childhood
KW  - Environmental Exposure
KW  - Electromagnetic Fields -- Adverse Effects
KW  - Funding Source
KW  - Case Control Studies
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Logistic Regression
KW  - Dose-Response Relationship, Radiation
KW  - Risk Assessment
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Male
KW  - Female
KW  - Human
SP  - 1
EP  - 7
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 337
IS  - 1
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Suite 408, Bethesda, MD
U2  - PMID: 9203424.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107266690&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107254955
T1  - Trial of calcium to prevent preeclampsia.
AU  - Levine RJ
AU  - Hauth JC
AU  - Curet LB
AU  - Sibai BM
AU  - Catalano PM
AU  - Morris CD
AU  - DerSimonian R
AU  - Esterlitz JR
AU  - Raymond EG
AU  - Bild DE
AU  - Clemens JD
AU  - Cutler JA
Y1  - 1997/07/10/
N1  - Accession Number: 107254955. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by the National Institute of Child Health and Human Development under contracts N01-HD-1-3121 through 3126, N01-HD-2-3154, and N01-HD-5-3246, with co-funding from the National Heart, Lung, and Blood Institute. NLM UID: 0255562. 
KW  - Calcium -- Therapeutic Use -- In Pregnancy
KW  - Pre-Eclampsia -- Prevention and Control
KW  - Pregnancy Outcomes
KW  - Mantel-Haenszel Test
KW  - Fisher's Exact Test
KW  - Pregnancy Complications, Cardiovascular -- Epidemiology
KW  - Case Control Studies
KW  - Random Assignment
KW  - Urinalysis
KW  - Proteinuria -- Epidemiology
KW  - Funding Source
KW  - Blood Pressure Determination
KW  - Adult
KW  - Pregnancy
KW  - Female
KW  - Human
SP  - 69
EP  - 76
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 337
IS  - 2
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 6100, Rm. 7B03, Bethesda, MD 20892-7510
U2  - PMID: 9211675.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107254955&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105819547
T1  - Handling of gene-transfer products by the National Institutes of Health Clinical Center pharmacy department.
AU  - DeCederfelt HJ
AU  - Grimes GJ
AU  - Green L
AU  - DeCederfelt RO
AU  - Daniels CE
Y1  - 1997/07/15/1997 Jul 15
N1  - Accession Number: 105819547. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023. 
KW  - Decontamination, Hazardous Materials -- Methods
KW  - Genes
KW  - Genetic Techniques
KW  - Pharmacy Service -- Standards
KW  - Education, Pharmacy
KW  - National Institutes of Health (U.S.)
KW  - Occupational Exposure -- Prevention and Control
KW  - Pharmacy Service -- Administration
KW  - Practice Guidelines
KW  - Protective Clothing
KW  - Safety
KW  - United States
SP  - 1604
EP  - 1610
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
JA  - AM J HEALTH SYST PHARM AJHP
VL  - 54
IS  - 14
CY  - Bethesda, Maryland
PB  - American Society of Health System Pharmacists
AB  - Policies and procedures for handling gene-transfer products at the National Institutes of Health (NIH) Clinical Center pharmacy department are described. The pharmacy at the Clinical Center is responsible for handling in vivo gene-transfer delivery systems, which are gene-transfer products that are prepared for direct administration to patients. The gene-transfer products currently handled by the pharmacy are investigational and are composed of viruses containing the gene encoding either of the melanoma antigens MART-1 and gp100. The pharmacy has prepared guidelines, based on the principles of aseptic technique and FDA guidelines for manufacturing facilities, intended to help pharmacy personnel safely dilute a concentrated gene-transfer product into a dose suitable for administration. Before a product is handled, the biological safety level is determined and a biohazard sign is posted. Worksheets detailing all supplies, calculations for dilutions, and procedures that will be required are prepared in advance; the worksheets are part of a drug fact sheet prepared for all investigational drugs dispensed. Personnel must be properly trained and dressed in protective clothing. Aseptic technique and decontamination procedures are used as specified in the guidelines, and all materials used are disposed of as biohazardous waste. All work is documented. If a worker is accidentally exposed, standard procedures are followed. The handling of gene-transfer products at the NIH Clinical Center pharmacy is based on the principles of aseptic technique, FDA guidelines, and experience.
SN  - 1079-2082
AD  - Pharmacy Department, Warren Grant Magnuson Clinical Center (WGMCC), National Institutes of Health, Bethesda, MD 20892-1196, USA. hdecederfe@pop.cc.nih.gov
U2  - PMID: 9248603.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105819547&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Landsberger, Nicoletta
AU  - Wolffe, Alan P.
T1  - Remodeling of regulatory nucleoprotein complexes on the Xenopus hsp70 promoter during meiotic maturation of the Xenopus oocyte.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/07/15/
VL  - 16
IS  - 14
M3  - Article
SP  - 4361
EP  - 4373
SN  - 02614189
AB  - Transcriptional repression occurs during meiotic maturation of Xenopus oocytes. Injection of a DNA template containing an hsp70 promoter into Xenopus oocytes, followed by progesterone-induced maturation has been used to demonstrate a dynamic competition between the assembly of transcription factor-containing nucleoprotein complexes and repressive nucleosomal arrays during the maturation process. In particular, it is shown that increased levels of injected heat shock protein, the transcriptional activator Gal4–VP16 or the DNA template itself all lead to reduced repression of transcription on maturation. Conversely, injection of additional histone increases repression. Repression of transcription is shown to be accompanied by the formation of a more regular array of nucleosomes and by an increase in the efficiency of nucleosome assembly on the injected plasmid. Meiotic maturation is therefore accompanied by replacement of transcription factor complexes by a repressive chromatin environment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENETIC transcription
KW  - XENOPUS
KW  - DNA
KW  - PROMOTERS (Genetics)
KW  - PROGESTERONE
KW  - TRANSCRIPTION factors
KW  - NUCLEOPROTEINS
KW  - HISTONES
KW  - CHROMATIN
KW  - heat shock
KW  - meiosis
KW  - nucleoprotein
KW  - transcription repression
KW  - xenopus
N1  - Accession Number: 13005611; Landsberger, Nicoletta 1 Wolffe, Alan P. 1; Email Address: awlme@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Building, Room 106, Bethesda, MD, USA; Source Info: 7/15/97, Vol. 16 Issue 14, p4361; Subject Term: GENETIC transcription; Subject Term: XENOPUS; Subject Term: DNA; Subject Term: PROMOTERS (Genetics); Subject Term: PROGESTERONE; Subject Term: TRANSCRIPTION factors; Subject Term: NUCLEOPROTEINS; Subject Term: HISTONES; Subject Term: CHROMATIN; Author-Supplied Keyword: heat shock; Author-Supplied Keyword: meiosis; Author-Supplied Keyword: nucleoprotein; Author-Supplied Keyword: transcription repression; Author-Supplied Keyword: xenopus; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/16.14.4361
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tilly, Kit
AU  - Casjens, Sherwood
AU  - Stevenson, Brian
AU  - Bono, James L.
AU  - Samuels, D. Scott
AU  - Hogan, Daniel
AU  - Rosa, Patricia
T1  - The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997/07/15/
VL  - 25
IS  - 2
M3  - Article
SP  - 361
EP  - 373
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The 26 to 28 kb circular plasmid of <em>B. burgdorferi sensu lato</em> (cp26) is ubiquitous among bacteria of this group and contains loci implicated in the mouse-tick transmission cycle. Restriction mapping and Southern hybridization indicated that the structure of cp26 is conserved among isolates from different origins and culture passage histories. The cp26 <em>ospC</em> gene encodes an outer surface protein whose synthesis within infected ticks increases when the ticks feed, and whose synthesis in culture increases after a temperature upshift. Previous studies of <em>ospC</em> coding sequences showed them to have stretches of sequence apparently derived from the <em>ospC</em> genes of distantly related isolates by homologous recombination after DNA transfer. We found conservation of the promoter regions of the <em>ospC</em> and <em>guaA</em> genes, which are divergently transcribed. We also demonstrated that the increase in <em>OspC</em> protein after a temperature upshift parallels increases in mRNA levels, as expected if regulatory regions adjoin the conserved sequences in the promoter regions. Finally, we used directed insertion to inactivate the ospC gene of a non-infectious isolate. This first example of directed gene inactivation in <em>B. burgdorferi</em> shows that the OspC protein is not required for stable maintenance of cp26 or growth in culture. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Borrelia burgdorferi
KW  - Plasmids
KW  - Protein synthesis
KW  - Lyme disease
KW  - Messenger RNA
KW  - Genetic recombination
N1  - Accession Number: 21300740; Tilly, Kit 1; Email Address: ktilly@nih.gov; Casjens, Sherwood 2; Stevenson, Brian 1; Bono, James L. 1; Samuels, D. Scott 3; Hogan, Daniel 1; Rosa, Patricia 1; Affiliations: 1: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA; 2: Division of Molecular Biology and Genetics, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84132, USA; 3: Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA; Issue Info: Jul1997, Vol. 25 Issue 2, p361; Subject Term: Borrelia burgdorferi; Subject Term: Plasmids; Subject Term: Protein synthesis; Subject Term: Lyme disease; Subject Term: Messenger RNA; Subject Term: Genetic recombination; Number of Pages: 13p; Illustrations: 4 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107243762
T1  - Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study [corrected] [published erratum appears in AM J CLIN NUTR 1997 Dec; 66(6): 1491].
AU  - Albanes D
AU  - Virtamo J
AU  - Taylor PR
AU  - Rautalahti M
AU  - Pietinen P
AU  - Heinonen OP
Y1  - 1997/08//
N1  - Accession Number: 107243762. Language: English. Entry Date: 19980201. Revision Date: 20150819. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Food-Use Questionnaire. Grant Information: National Cancer Institute contract NO1-CN-45165. NLM UID: 0376027. 
KW  - Beta Carotene -- Administration and Dosage
KW  - Alcohol Drinking
KW  - Smoking
KW  - Carotenoids
KW  - Dietary Supplementation
KW  - Vitamin E -- Administration and Dosage
KW  - Vitamin A -- Analysis
KW  - Carotenoids -- Analysis
KW  - Funding Source
KW  - Intervention Trials
KW  - Placebos
KW  - Double-Blind Studies
KW  - Random Assignment
KW  - Factorial Design
KW  - Questionnaires
KW  - T-Tests
KW  - Wilcoxon Rank Sum Test
KW  - Spearman's Rank Correlation Coefficient
KW  - Linear Regression
KW  - Data Analysis Software
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Human
SP  - 366
EP  - 372
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 66
IS  - 2
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - We determined whether serum carotenoid or retinol concentrations were altered by beta-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use. Participants in this substudy were 491 randomly selected men aged 58-76 y from the metropolitan Helsinki study center [237 receiving supplemental beta-carotene (20 mg/d) and 254 not receiving such supplementation]. Dietary carotenoids, retinol, and alcohol, and serum beta-carotene, alpha-tocopherol, retinol, and cholesterol were assessed at baseline. After an average of 6.7 y of supplementation, serum was collected and carotenoid, retinol, and alpha-tocopherol concentrations were determined by HPLC. Serum carotenoid fractions were highly correlated with each other (P < or = 0.0001). Compared with the unsupplemented group, the beta-carotene group had significantly higher serum concentrations of beta-carotene (1483%), alpha-carotene (145%), and beta-cryptoxanthin (67%) (P < or = 0.0001). Retinol concentrations were 6% higher (P = 0.03) and lutein was 11% lower (P = 0.02) in the supplemented group. Serum lycopene, zeaxanthin, and alpha-tocopherol did not differ according to beta-carotene-supplementation status. Although these beta-carotene-group differences were not significantly altered by amount of alcohol consumption, higher consumption (> 12.9 g/d, median) was related to lower (10-38%) concentrations of carotenoids, particularly beta-carotene, alpha-carotene, and beta-cryptoxanthin, in both the supplemented and unsupplemented groups. Smoking status did not significantly influence the supplementation-related differences in serum carotenoid and retinol values but concentrations of carotenoids were generally highest in participants who quit smoking while in the study and lowest in current smokers of > or = 20 cigarettes/d. This study showed that serum concentrations of non-beta-carotene carotenoids are altered by long-term beta-carotene supplementation and confirms the adverse effects of alcohol and cigarette smoking on serum carotenoids. Copyright (c) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Cancer Institute, Executive Plaza North-Ste 211, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 9250116.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Robertson, Elizabeth B.
AU  - Donnermeyer, Joseph F.
T1  - Illegal Drug Use among Rural Adults: Mental Health Consequences and Treatment Utilization.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1997/08//
VL  - 23
IS  - 3
M3  - Article
SP  - 467
EP  - 484
SN  - 00952990
AB  - This study uses the National Household Survey on Drug Abuse to examine mental health consequences and treatment utilization among nonmetropolitan and rural adults. The study employs an ecological systems perspective, dividing the study population into three groups: nonmetropolitan-rural, nonmetropolitan-urban, and metropolitan-rural. Logistic regression analysis is used to examine four sets of factors related to self-report of mental health problems among drug-using adults, including community level features, family characteristics, personal characteristics, and stress factors. Perceived ease of purchasing cocaine, number of moves in last five years, employment in blue collar occupations, number of jobs in last five years, and residence in neighborhoods with a low rate ( < 10%) of minority households were significantly related to self-report problems. Results of the analysis are discussed in terms of barriers to utilization of treatment and rehabilitation services among nonmetropolitan and rural adults, such as availability and access to facilities and professional services, social stigma, ability to afford services, and the difficulty for rural communities to support in-hospital and outpatient services. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse
KW  - SUBSTANCE abuse
KW  - MENTAL health
KW  - PUBLIC health
KW  - HOSPITAL care
KW  - MEDICAL care
N1  - Accession Number: 9708222910; Robertson, Elizabeth B. 1 Donnermeyer, Joseph F. 2; Affiliation:  1: National Institute on Drug Abuse, Rockville, Maryland.  2: Ohio State University, Columbus, Ohio.; Source Info: 1997, Vol. 23 Issue 3, p467; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: MENTAL health; Subject Term: PUBLIC health; Subject Term: HOSPITAL care; Subject Term: MEDICAL care; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 18p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107343487
T1  - Programmed instruction: cancer genetics. Genetic testing for cancer predisposition.
AU  - Biesecker BB
Y1  - 1997/08//1997 Aug
N1  - Accession Number: 107343487. Language: English. Entry Date: 19971101. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Genetic Screening
KW  - Neoplasms
KW  - Neoplasms -- Etiology
KW  - Education, Continuing (Credit)
KW  - Programmed Instruction
KW  - Consent
KW  - Genetic Screening -- Psychosocial Factors
KW  - Genetic Screening -- History
KW  - Genetic Screening -- Classification
KW  - Ethics, Medical
KW  - Nursing Role
SP  - 285
EP  - 300
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 20
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0162-220X
AD  - National Institutes of Health, Building 10, Room 10C101, 10 Center Drive MSC 1852, Bethesda, MD 20892-1852
U2  - PMID: 9265816.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107288141
T1  - Focus groups with cancer patients: toward a more comprehensive understanding of the cancer experience.
AU  - Ashbury FD
AU  - Lockyer L
AU  - McKerracher K
AU  - Findlay H
Y1  - 1997/08//1997 Aug
N1  - Accession Number: 107288141. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Canada; Peer Reviewed. Grant Information: Ortho Biotech. NLM UID: 9709994. 
KW  - Cancer Patients -- Psychosocial Factors
KW  - Life Change Events
KW  - Neoplasms -- Psychosocial Factors
KW  - Economic Aspects of Illness
KW  - Focus Groups
KW  - Qualitative Studies
KW  - Audiorecording
KW  - Data Analysis Software
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 222
EP  - 227
JO  - Cancer Prevention & Control
JF  - Cancer Prevention & Control
JA  - CANCER PREV CONTROL
VL  - 1
IS  - 3
CY  - Ottawa, ON, Ontario
PB  - Canadian Medical Association
SN  - 1206-548X
AD  - Centre for Behavioural Research and Program Evaluation, National Cancer Institute of Canada, 10 Alcorn Ave., Suite 200, Toronto ON M4V 3B1. E-mail: cappe@netcome.ca
U2  - PMID: 9765747.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Robin, Robert W.
AU  - Chester, Barbara
AU  - Rasmussen, Jolene K.
AU  - Jaranson, James M.
AU  - Goldman, David
T1  - PREVALENCE, CHARACTERISTICS, AND IMPACT OF CHILDHOOD SEXUAL ABUSE IN A SOUTHWESTERN AMERICAN INDIAN TRIBE.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1997/08//
VL  - 21
IS  - 8
M3  - Article
SP  - 769
EP  - 787
SN  - 01452134
AB  - Objective: There were two objectives: first, to investigate the prevalence and characteristics of child sexual abuse in an American Indian community, and second, to determine whether persons with histories of child sexual abuse are at greater risk to develop psychiatric disorders and behavioral problems than persons who report no such history. Method: A sample of 582 Southwestern American Indian tribal members was collected for a genetic and linkage study on alcoholism and psychiatric disorders in three large and interrelated pedigrees. Subjects were recruited from the community without knowledge of their clinical histories or those of their relatives. Child sexual abuse and psychiatric disorders were assessed using a semi-structured psychiatric interview. Results: Females were more likely to be sexually abused as children (49%) than were males (14%). Intrafamilial members accounted for 78% of the reported child sexual abuse. Sexually abused males and females were more likely to report childhood and adult behavioral problems than were nonabused subjects. There was a strong relationship between multiple psychiatric disorders and child sexual abuse, with sexually abused males and females more likely to be diagnosed with ≥3 psychiatric disorders, both including and excluding alcohol dependence or abuse, than were nonabused subjects. Conclusion: Child sexual abuse in this population is both an index of family dysfunction and community disorganization as well as a predictor of later behavioral patterns and psychopathology. (English) [ABSTRACT FROM AUTHOR]
AB  - Objetivo: Los objetivos son dos. Primero, investigar la prevalencia y caractersticas del abuso sexual a los nios en una comunidad de indios americanos; y segundo, determinar si las personas con una historia de abuso sexual en la niez tienen mayor riesgo de sufrir desrdenes psiquitricos y problemas conductuales que las personas no abusadas. Mtodo: Se obtuvo una muestra de 582 indios americanos, miembros de una tribu del suroeste, para un estudio gentico y de relacin sobre el alcoholismo y desrdenes psiquitricos en tres grandes "pedigrees" (historias familiares) interrelacionados. Los sujetos fueron reclutados de la comunidad sin conocimiento de sus historias clnicas o la de sus familiares. Se evaluaron los desrdenes mentales y las experiencias de abuso en la niez, con una entrevista psiquitrica semi- estructurada. Resultados: Las mujeres tenan ms riesgo de ser sexualmente abusadas en la niez (50%) que los varones (14%). El 78% de los casos de abuso sexual en la niez reportado era intrafamiliar. Los varones y las mujeres abusadas sexualmente en la niez aparecen ms propensos a reportar problemas conductuales, tanto en la niez como en la adultez, que los sujetos no abusados. Se obtuvo una fuerte correlacin entre mltiples desrdenes psiquitricos y el abuso sexual en la niez, en que los varones y las mujeres sexualmente abusados tenan ms probabilidad de ser diagnsticados con > de 3 desrdenes psiquitricos, que los sujetos no abusados. Conclusin: El abuso sexual en la niez en esta poblacin es tanto un indicador de disfuncin familiar y desorganizacion comunitaria como tambin anticipan posteriores patrones conductuales y psicopatologa. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Objectif: Il y avait deux objectifs. Premirement, valuer la prvalence et les caractristique de l'abus sexuel des enfants dans une communaut amrindienne, et deuximement, dterminer si les personnes avec des antcdents d'abus sexuels au cours de l'enfance sont plus  risque de dvelopper des maladies psychiatriques et des problmes de comportement que les personnes n'ayant pas signal ces antcdents. Mthode: Un chantillon de 582 membres d'une tribu amrindienne du sud-ouest a t runi pour une tude gntique sur l'alcoolisme et les maladies psychiatriques  l'intrieur de trois pedigrs relis entre eux. Les sujets ont t recruts dans la communaut sans connaissance pralable de leur histoire clinique ou celle de leurs proches. L'abus sexuel et les maladies psychiatriques ont t valus  l'aide d'un interrogatoire psychiatrique semi-structur. Rsultats: Les femmes prsentaient plus d'abus sexuel au cours de l'enfance (50%) que les hommes (14%); les auteurs de l'abus sexuels faisaient partie de la famille dans 78% des cas. Les hommes et les femmes abuss sexuellement signalaient plus de troubles du comportement au cours de l'enfance et  l'ge adulte que les autres sujets non-abuss. La corrlation entre l'abus sexuel et de multiples problmes psychiatriques tait trs forte, puisque les hommes et les femmes abuss sexuellement souffraient souvent de plus de 3 problmes psychiatriques, avec ou sans alcoolisme et toxicomanie. Conclusion: L'abus sexuel dans cette population est  la fois un indicateur de dysfonctionnements familiaux et de dsorganisation de la communaut ainsi qu'un prdicateur de problmes du comportement et de psychopathologie  long terme. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD sexual abuse
KW  - CHILD abuse
KW  - MENTAL illness
KW  - ALCOHOLISM
KW  - NATIVE Americans
KW  - American Indian
KW  - Child sexual abuse
KW  - Intrafamilial abuse
KW  - Perpetrator
KW  - Victimization
N1  - Accession Number: 9708110783; Robin, Robert W. 1 Chester, Barbara 2 Rasmussen, Jolene K. 3 Jaranson, James M. 4 Goldman, David 1; Affiliation:  1: Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA  2: Center for the Prevention and Resolution of Violence, Hopi Foundation, Tucson, AZ, USA  3: Department of Epidemiology, University of Arizona, Tucson, AZ, USA  4: Department of Psychiatry, University of Minnesota at St. Paul, Ramsey Medical Center, Minneapolis, MN, USA; Source Info: Aug97, Vol. 21 Issue 8, p769; Subject Term: CHILD sexual abuse; Subject Term: CHILD abuse; Subject Term: MENTAL illness; Subject Term: ALCOHOLISM; Subject Term: NATIVE Americans; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: Child sexual abuse; Author-Supplied Keyword: Intrafamilial abuse; Author-Supplied Keyword: Perpetrator; Author-Supplied Keyword: Victimization; Number of Pages: 19p; Illustrations: 8 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thurau, S. R.
AU  - C.-C. Chan
AU  - Nussenblatt, R. B.
AU  - Caspi, R. R.
T1  - Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals.
JO  - Clinical & Experimental Immunology
JF  - Clinical & Experimental Immunology
Y1  - 1997/08//
VL  - 109
IS  - 2
M3  - Article
SP  - 370
EP  - 376
PB  - Wiley-Blackwell
SN  - 00099104
AB  - Oral administration of uveitogenic retinal antigens suppresses the expression of EAU induced by a subsequent immunization with these antigens. Effectiveness and mechanisms of oral tolerance in EAU have mainly been studied in the acute, monophasic model in Lewis rats by feeding antigen prior to induction of disease. In this study we investigated the effect of oral tolerance induction in the acute as well as the chronic-relapsing models in the B10.A mouse. In acute murine EAU we could effectively suppress disease by induction of oral tolerance prior to immunization. In the chronic-relapsing EAU, antigen feeding was started only after the animals had recovered from their first attack of uveitis. Under these experimental conditions the subsequent relapse was largely prevented. These experiments demonstrate that oral tolerance may have practical clinical implications in uveitis, which is predominantly a chronic-relapsing condition in humans. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - UVEITIS
KW  - ANTIGENS
KW  - MICE as laboratory animals
KW  - IMMUNITY
KW  - LABORATORY animals
KW  - IMMUNIZATION
KW  - autoantigens
KW  - chronic relapsing autoimmune
KW  - oral tolerance
KW  - T lymphocytes
KW  - uveitis
N1  - Accession Number: 16223258; Thurau, S. R. 1 C.-C. Chan 1 Nussenblatt, R. B. 1 Caspi, R. R. 1; Affiliation:  1: Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD, USA.; Source Info: Aug1997, Vol. 109 Issue 2, p370; Subject Term: UVEITIS; Subject Term: ANTIGENS; Subject Term: MICE as laboratory animals; Subject Term: IMMUNITY; Subject Term: LABORATORY animals; Subject Term: IMMUNIZATION; Author-Supplied Keyword: autoantigens; Author-Supplied Keyword: chronic relapsing autoimmune; Author-Supplied Keyword: oral tolerance; Author-Supplied Keyword: T lymphocytes; Author-Supplied Keyword: uveitis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hamer, Dean
T1  - The Search for Personality Genes: Adventures of a Molecular Biologist.
JO  - Current Directions in Psychological Science
JF  - Current Directions in Psychological Science
Y1  - 1997/08//
VL  - 6
IS  - 4
M3  - Article
SP  - 111
EP  - 114
PB  - Sage Publications Inc.
SN  - 09637214
AB  - All human beings are comprised of DNA. Within the 3 billion base-pair building blocks that constitute the human genome are the instructions for both the human body and the brain. What makes each one of us unique is also in part determined by DNA, for within the genome there are some 3 million bases that may differ from one person to the next. These differences in DNA have an important impact on how people think, act, and feel. Broad personality traits such as neuroticism or extraversion, specific behaviors such as smoking cigarettes or drinking alcohol, and even subjective states such as happiness all show substantial heritability; typically, 40% to 60% of the variation between people is due to genes.
KW  - DNA
KW  - HUMAN genome
KW  - EXTRAVERSION
KW  - PERSONALITY
KW  - BEHAVIOR genetics
N1  - Accession Number: 11514443; Hamer, Dean 1; Affiliation:  1: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Aug97, Vol. 6 Issue 4, p111; Subject Term: DNA; Subject Term: HUMAN genome; Subject Term: EXTRAVERSION; Subject Term: PERSONALITY; Subject Term: BEHAVIOR genetics; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1467-8721.ep11514443
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chean Eng Ooi
AU  - Moreira, Jorge E.
AU  - Dell'Angelica, Esteban C.
AU  - Poy, George
AU  - Wassarman, David A.
AU  - Bonifacino, Juan S.
T1  - Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/08//8/1/97
VL  - 16
IS  - 15
M3  - Article
SP  - 4508
EP  - 4518
SN  - 02614189
AB  - Drosophila eye pigmentation defects have thus far been attributed to mutations in genes encoding enzymes required for biosynthesis of pigments and to ABC-type membrane transporters for pigments or their precursors. We report here that a defect in a gene encoding a putative coat adaptor protein leads to the eye color defect of garnet mutants. We first identified a human cDNA encoding δ-adaptin, a structural homolog of the α- and γ-adaptin subunits of the clathrin coat adaptors AP-1 and AP-2, respectively. Biochemical analyses demonstrated that δ-adaptin is a component of the adaptor-like complex AP-3 in human cells. We then isolated a full-length cDNA encoding the Drosophila ortholog of δ-adaptin and found that transcripts specified by this cDNA are altered in garnet mutant flies. Examination by light and electron microscopy indicated that these mutant flies have reduced numbers of eye pigment granules, which correlates with decreased levels of both pteridine (red) and ommachrome (brown) pigments. Thus, the eye pigmentation defect in the Drosophila garnet mutant may be attributed to compromised function of a coat protein involved in intracellular transport processes required for biogenesis or function of pigment granules. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BIOSYNTHESIS
KW  - ORGANIC synthesis (Chemistry)
KW  - ENZYMES
KW  - DROSOPHILA
KW  - BIOCHEMISTRY
KW  - GENETICS
KW  - MUTATION (Biology)
KW  - adaptin
KW  - garnet
KW  - granules
KW  - pigment
KW  - sorting
N1  - Accession Number: 13005661; Chean Eng Ooi 1 Moreira, Jorge E. 1 Dell'Angelica, Esteban C. 1 Poy, George 2 Wassarman, David A. 1 Bonifacino, Juan S. 1; Email Address: Juan@helix.nih.gov; Affiliation:  1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development  2: Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: 8/1/97, Vol. 16 Issue 15, p4508; Subject Term: BIOSYNTHESIS; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: ENZYMES; Subject Term: DROSOPHILA; Subject Term: BIOCHEMISTRY; Subject Term: GENETICS; Subject Term: MUTATION (Biology); Author-Supplied Keyword: adaptin; Author-Supplied Keyword: garnet; Author-Supplied Keyword: granules; Author-Supplied Keyword: pigment; Author-Supplied Keyword: sorting; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 11p; Document Type: Article
L3  - 10.1093/emboj/16.15.4508
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tsung-Chang Sung
AU  - Roper, Rachel L.
AU  - Yue Zhang
AU  - Rudge, Simon A.
AU  - Temel, Ryan
AU  - Hammond, Scott M.
AU  - Morris, Andrew J.
AU  - Moss, Bernard
AU  - Engebrecht, JoAnne
AU  - Frohman, Michael A.
T1  - Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/08//8/1/97
VL  - 16
IS  - 15
M3  - Article
SP  - 4519
EP  - 4530
SN  - 02614189
AB  - Phospholipase D (PLD) genes are members of a superfamily that is defined by several highly conserved motifs. PLD in mammals has been proposed to play a role in membrane vesicular trafficking and signal transduction. Using site-directed mutagenesis, 25 point mutants have been made in human PLD1 (hPLD1) and characterized. We find that a motif (HxKxxxxD) and a serine/threonine conserved in all members of the PLD superfamily are critical for PLD biochemical activity, suggesting a possible catalytic mechanism. Functional analysis of catalytically inactive point mutants for yeast PLD demonstrates that the meiotic phenotype ensuing from PLD deficiency in yeast derives from a loss of enzymatic activity. Finally, mutation of an HxKxxxxD motif found in a vaccinia viral protein expressed in the Golgi complex results in loss of efficient vaccinia virus cell-to-cell spreading, implicating the viral protein as a member of the superfamily and suggesting that it encodes a lipid modifying or binding activity. The results suggest that vaccinia virus and hPLD1 may act through analogous mechanisms to effect viral cellular egress and vesicular trafficking, respectively. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHOLIPASES
KW  - GENES
KW  - MUTAGENESIS
KW  - VIRAL proteins
KW  - CELL organelles
KW  - VIRUS diseases
KW  - MUTATION (Biology)
KW  - MICROBIAL genetics
KW  - phospholipase d (pld)
KW  - spo14
KW  - vaccinia virus
KW  - vp37
N1  - Accession Number: 13005660; Tsung-Chang Sung 1 Roper, Rachel L. 2 Yue Zhang 3 Rudge, Simon A. 1 Temel, Ryan 1 Hammond, Scott M. 1 Morris, Andrew J. 1,4 Moss, Bernard 2 Engebrecht, JoAnne 1,4 Frohman, Michael A. 1,4; Email Address: Michael@pharm.som.sunysb.edu; Affiliation:  1: Department of Pharmacological Sciences, SUNY at Stony Brook, NY  2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA  3: Molecular and Cellular Biology Program, SUNY at Stony Brook, Stony Brook, NY  4: The Institute for Cell and Developmental Biology, SUNY at Stony Brook, Stony Brook, NY; Source Info: 8/1/97, Vol. 16 Issue 15, p4519; Subject Term: PHOSPHOLIPASES; Subject Term: GENES; Subject Term: MUTAGENESIS; Subject Term: VIRAL proteins; Subject Term: CELL organelles; Subject Term: VIRUS diseases; Subject Term: MUTATION (Biology); Subject Term: MICROBIAL genetics; Author-Supplied Keyword: phospholipase d (pld); Author-Supplied Keyword: spo14; Author-Supplied Keyword: vaccinia virus; Author-Supplied Keyword: vp37; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/16.15.4519
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Georgel, Philippe T.
AU  - Tsukiyama, Toshio
AU  - Wu, Carl
T1  - Role of histone tails in nucleosome remodeling by Drosophila NURF.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/08//8/1/97
VL  - 16
IS  - 15
M3  - Article
SP  - 4717
EP  - 4726
SN  - 02614189
AB  - The Drosophila nucleosome remodeling factor NURF utilizes the energy of ATP hydrolysis to perturb the structure of nucleosomes and facilitate binding of transcription factors. The ATPase activity of purified NURF is stimulated significantly more by nucleosomes than by naked DNA or histones alone, suggesting that NURF is able to recognize specific features of the nucleosome. Here, we show that the interaction between NURF and nucleosomes is impaired by proteolytic removal of the N-terminal histone tails and by chemical cross-linking of nucleosomal histones. The ATPase activity of NURF is also competitively inhibited by each of the four Drosophila histone tails expressed as GST fusion proteins. A similar inhibition is observed for a histone H4 tail substituted with glutamine at four conserved, acetylatable lysines. These findings indicate a novel role for the flexible histone tails in chromatin remodeling by NURF, and this role may, in part, be independent of histone acetylation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DROSOPHILA
KW  - TRANSCRIPTION factors
KW  - ADENOSINE triphosphatase
KW  - HISTONES
KW  - PROTEINS
KW  - ACETYLATION
KW  - MOLECULAR biology
KW  - drosophila
KW  - histone tails
KW  - nucleosome remodeling
KW  - nurf
N1  - Accession Number: 13005640; Georgel, Philippe T. 1 Tsukiyama, Toshio 1 Wu, Carl 1; Affiliation:  1: Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, USA; Source Info: 8/1/97, Vol. 16 Issue 15, p4717; Subject Term: DROSOPHILA; Subject Term: TRANSCRIPTION factors; Subject Term: ADENOSINE triphosphatase; Subject Term: HISTONES; Subject Term: PROTEINS; Subject Term: ACETYLATION; Subject Term: MOLECULAR biology; Author-Supplied Keyword: drosophila; Author-Supplied Keyword: histone tails; Author-Supplied Keyword: nucleosome remodeling; Author-Supplied Keyword: nurf; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/16.15.4717
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chapin, Robert E.
AU  - Sloane, Richard A.
AU  - Haseman, Joseph K.
T1  - The Relationships among Reproductive Endpoints in Swiss Mice, Using the Reproductive Assessment by Continuous Breeding Database1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/08//
VL  - 38
IS  - 2
M3  - Article
SP  - 129
EP  - 142
PB  - Oxford University Press / USA
SN  - 02720590
AB  - The database of Continuous Breeding mouse studies was evaluated to determine the relationships between the functional indicators of reproduction (pup measures) and the various necropsy endpoints collected for males and females. Of 72 chemicals studied, both males and females were affected in 33 studies, while females and/or conceptuses were affected in 7. Two compounds affected only males, 17 studies were negative, and in 13 studies with effects it was not possible to clearly determine the affected gender(s). Greater F0 dam weight was correlated with increased pup mass per litter; this relationship was strongest for the first litter, and weakest for the fifth litter. For both generations of treated females (F0 and F1), longer estrous cycles correlated with reduced numbers of pups; the relationship was stronger in F0 than in F1, females and was not seen in controls. Sperm parameters had different distributions in treated mice than in control mice. Fertility (total live pups/number of pairs cohabited) was reduced if there were > ˜15% sperm abnormalities or if sperm motility (moving/ not moving) was < ≈37%. Both of these relationships appeared to have thresholds. Epididymal sperm count in treated animals, however, was linearly related to fertility, even within the control range, suggesting strongly that other factors are important Using both treated and control data together, combining sperm count with motility could explain much (r ≈ 0.77) of the variation in fertility; adding morphology did not significantly improve the correlation. The model was almost as strong using count and morphology, in which case adding motility did not strengthen the model. This analysis of these studies shows that while some end-points (e.g., random-estrous-cycle-point ovary weight) correlate poorly with fertility, other necropsy endpoints (epididymal sperm count and motility, estrous cycle length, and testis and epididymal weights) can be useful (though not complete) surrogates of overall reproductive function. Indeed, over many studies, epididymal sperm count in treated animals correlates with fertility so well that even small reductions (≈20%) in count result in reduced fertility, suggesting that mice may be better models of human fertility than was previously believed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxicology
KW  - Autopsy
KW  - Spermatozoa
KW  - Sperm count
KW  - Mice as laboratory animals
N1  - Accession Number: 82413015; Chapin, Robert E. 1,2; Sloane, Richard A. 1,2; Haseman, Joseph K. 1; Affiliations: 1: Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, North Carolina 27709; 2: Reproductive Toxicology Group, Environmental Toxicology Program PO Box 12233, Research Triangle Park, North Carolina 27709; Issue Info: 1997, Vol. 38 Issue 2, p129; Thesaurus Term: Toxicology; Subject Term: Autopsy; Subject Term: Spermatozoa; Subject Term: Sperm count; Subject Term: Mice as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107338569
T1  - Phase III double-blind comparison of dolasetron mesylate and ondansetron and an evaluation of the additive role of dexamethasone in the prevention of acute and delayed nausea and vomiting due to moderately emetogenic chemotherapy.
AU  - Lofters WS
AU  - Pater JL
AU  - Zee B
AU  - Dempsey E
AU  - Walde D
AU  - Moquin J
AU  - Wilson K
AU  - Hoskins P
AU  - Guevin RM
AU  - Verma S
AU  - Navari R
AU  - Krook JE
AU  - Hainsworth J
AU  - Palmer M
AU  - Chin C
AU  - Lofters, W S
AU  - Pater, J L
AU  - Zee, B
AU  - Dempsey, E
AU  - Walde, D
Y1  - 1997/08//
N1  - Accession Number: 107338569. Language: English. Entry Date: 19971001. Revision Date: 20161120. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Quality of Life Questionnaire (QLQ-C30). Grant Information: Hoechst-Marion Roussel, Montreal, and the National Cancer Institute of Canada, Toronto, Canada. NLM UID: 8309333. 
KW  - Dolasetron -- Therapeutic Use
KW  - Nausea -- Prevention and Control
KW  - Vomiting -- Prevention and Control
KW  - Chemotherapy, Cancer -- Adverse Effects
KW  - Nausea -- Drug Therapy
KW  - Dexamethasone -- Therapeutic Use
KW  - Vomiting -- Drug Therapy
KW  - Ondansetron -- Therapeutic Use
KW  - Quality of Life
KW  - Drug Therapy, Combination
KW  - Drug Evaluation
KW  - Research Instruments
KW  - Clinical Trials
KW  - Double-Blind Studies
KW  - Data Analysis Software
KW  - T-Tests
KW  - Chi Square Test
KW  - Multiple Logistic Regression
KW  - Cox Proportional Hazards Model
KW  - Funding Source
KW  - Human
SP  - 2966
EP  - 2973
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 15
IS  - 8
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To compare the efficacy of dolasetron and ondansetron in controlling nausea and vomiting in the first 24 hours; to evaluate the efficacy when dexamethasone is added to either drug in the first 24 hours; and to extend these comparisons over 7 days in patients receiving moderately emetogenic chemotherapy.Patients and Methods: This was a multicenter, double-blind, randomized study with six parallel arms that used a 2 x 2 factorial design in chemotherapy-naive patients. In arm 1, dolasetron (2.4 mg/kg) was given intravenously (I.V.) prechemotherapy, followed 24 hours later by oral dolasetron (200 mg once daily) for 6 days. Arms 2 and 3 consisted of dolasetron and dexamethasone 8 mg I.V., followed 24 hours later by oral dexamethasone (8 mg once daily) in one arm, and oral dexamethasone and dolasetron in the other, also for 6 days. In arms 4, 5, and 6, ondansetron (32 mg I.V. or 8 mg orally twice daily) was administered in a similar manner to arms 1, 2, and 3 before and 24 hours after chemotherapy. Mean nausea severity (MNS) was assessed on a visual analog scale (VAS) in a daily diary.Results: Of 703 patients enrolled, 696 were eligible. There were 343 dolasetron- and 353 ondansetron-treated patients; 57% of dolasetron-treated patients had complete protection in the first 24 hours versus 67% of patients who received ondansetron (P = .013). MNS was also more pronounced on the dolasetron arm (P = .051). Sixty-seven percent of patients who received added dexamethasone in the first 24 hours had complete protection, compared with 55% without dexamethasone (P < .001). MNS was significantly reduced with the addition of dexamethasone (P < .001). At 7 days, dolasetron and ondansetron had equivalent complete protection rates (36% and 39%, respectively). With the addition of dexamethasone, 48% of patients compared with 28% had complete protection (P < .001). MNS was significantly improved with added dexamethasone (P < .001).Conclusion: At the doses used, dolasetron was significantly less effective than ondansetron at controlling nausea and vomiting in the first 24 hours in patients receiving moderately emetogenic chemotherapy, but there was no demonstrable difference between both drugs over 7 days. The addition of dexamethasone significantly improved the efficacy of both drugs in the first 24 hours and over 7 days.
SN  - 0732-183X
AD  - Kingston Regional Cancer Centre, and National Cancer Institute of Canada Clinical Trials Group, Ontario
U2  - PMID: 9256141.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107264213
T1  - Genetic linkage studies of stuttering: ready for prime time?
AU  - Drayna DT
Y1  - 1997/08//1997 Aug
N1  - Accession Number: 107264213. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 7601744. 
KW  - Fluency Disorders -- Familial and Genetic
KW  - Research, Speech-Language-Hearing Therapy
KW  - Genetics
KW  - Epidemiological Research
KW  - Research Subject Recruitment
SP  - 237
EP  - 241
JO  - Journal of Fluency Disorders
JF  - Journal of Fluency Disorders
JA  - J FLUENCY DISORD
VL  - 22
IS  - 3
CY  - New York, New York
PB  - Elsevier Science
SN  - 0094-730X
AD  - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Masunaga, Takuji
AU  - Shimizu, Hiroshi
AU  - Yee, Carole
AU  - Borradori, Luca
AU  - Lazarova, Zelmira
AU  - Nishikawa, Takeji
AU  - Yancey, Kim B.
T1  - The Extracellular Domain of BPAG2 Localizes to Anchoring Filaments and its Carboxyl Terminus Extends to the Lamina Densa of Normal Human Epidermal Basement Membrane.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/08//
VL  - 109
IS  - 2
M3  - Article
SP  - 200
EP  - 206
SN  - 0022202X
AB  - Bullous pemphigoid antigen 2 (BPAG2) is a 180 kDa type II transmembrane protein associated with hemidesmosomes (HDs) in basal keratinocytes. To better understand how BPAG2 promotes keratinocyte adhesion to epidermal basement membrane (BM), purified IgG against a baculovirus-encoded recombinant was used to localize its carboxyl terminus in human skin by immunogold electron microscopy (IEM). A 2.1-kb BPAG2 cDNA encoding the distal extracellular domain and carboxyl terminus of BPAG2 was used in a baculovirus expression system to create virus that produced a 70-kDa recombinant form of BPAG2 (BV4). BV4 was purified, characterized, and used to raise high-titer specific rabbit IgG. Purified anti-BV4 IgG bound the epidermal side of 1 M NaC1 split skin and bound only BPAG2 on immunoblots containing extracts of human keratinocytes. In IEM studies of pre- and post-embedded skin, the distal ectodomain of BPAG2 localized beneath HDs in basal keratinocytes; there was no evidence of BPAG2 beneath melanocytes. Anti-BV4 IgG extensively bound anchoring filaments on the epidermal side of 1 M NaCI split skin; this staining extended along anchoring filaments to their ends. In post-embedded skin, the carboxyl terminus of BPAG2 was localized within the lamina densa, 41 nm (mean of 400 determinations) beneath plasma membranes of basal keratinocytes. BPAG2 thus extends from the intracellular HD plaque of basal keratinocytes to the lamina densa of human epidermal BM. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BASAL lamina
KW  - ANTIGENS
KW  - HEMIDESMOSOMES
KW  - KERATINOCYTES
KW  - CELL junctions
KW  - CELL adhesion
KW  - collagen
KW  - hemidesmosomes
KW  - laminin.
N1  - Accession Number: 12319337; Masunaga, Takuji 1,2 Shimizu, Hiroshi 1 Yee, Carole 3 Borradori, Luca 3 Lazarova, Zelmira 3 Nishikawa, Takeji 1 Yancey, Kim B. 3; Affiliation:  1: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.  2: Basic Research Laboratory, KOSÉ Corporation, Tokyo, Japan.  3: Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug97, Vol. 109 Issue 2, p200; Subject Term: BASAL lamina; Subject Term: ANTIGENS; Subject Term: HEMIDESMOSOMES; Subject Term: KERATINOCYTES; Subject Term: CELL junctions; Subject Term: CELL adhesion; Author-Supplied Keyword: collagen; Author-Supplied Keyword: hemidesmosomes; Author-Supplied Keyword: laminin.; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12319337
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Spritz, Richard A
AU  - Ho, Lingling
AU  - Furumura, Minao
AU  - Hearing, Jr., Vincent J
T1  - Mutational Analysis of Copper Binding by Human Tyrosinase.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/08//
VL  - 109
IS  - 2
M3  - Article
SP  - 207
EP  - 212
SN  - 0022202X
AB  - Tyrosinase (EC 1.14.18.1) is a copper-containing enzyme that catalyzes several reactions in the biosynthesis of melanin pigments and is deficient in patients with type I oculocutaneous albinism (OCA1). Tyrosinase is thought to bind two copper ions, one at each of two conserved sequence motifs, termed CuA and CuB, but to date this has been directly proved only for the <em>Neurospora</em> and mushroom enzyme. Here, we demonstrate that mammalian tyrosinase directly binds copper, and that the CuA and CuB sites are both required for copper binding and for catalytic activity. We show that in human tyrosinase, copper binding by the CuB site is most likely coordinated by residues His363, His367, and His389, and that copper binding may be cooperative, with copper binding at one site facilitating copper binding by the other site. Furthermore, correct folding of the tyrosinase polypeptide appears to be necessary for copper binding, and a number of human OCA1 mutations disrupt copper binding and thus catalytic function of tyrosinase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHENOL oxidase
KW  - MUTATION (Biology)
KW  - COPPER
KW  - MELANOGENESIS
KW  - OXIDASES
KW  - ENZYMES
KW  - BIOSYNTHESIS
KW  - albinism
KW  - hemocyanin
KW  - melanogenesis
N1  - Accession Number: 12319351; Spritz, Richard A 1 Ho, Lingling 1 Furumura, Minao 2 Hearing, Jr., Vincent J; Affiliation:  1: Departments of Medical Genetics and Pediatrics, Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin, U.S.A.  2: Laboratory of Cell Biology, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug97, Vol. 109 Issue 2, p207; Subject Term: PHENOL oxidase; Subject Term: MUTATION (Biology); Subject Term: COPPER; Subject Term: MELANOGENESIS; Subject Term: OXIDASES; Subject Term: ENZYMES; Subject Term: BIOSYNTHESIS; Author-Supplied Keyword: albinism; Author-Supplied Keyword: hemocyanin; Author-Supplied Keyword: melanogenesis; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12319351
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chatterjee, R.
AU  - Mukhopadhyay, D.
AU  - Chakraborty, R. N.
AU  - Mitra, R. Basu
T1  - Evaluation of argyrophilic nucleolar organizer regions (AgNORs) in oral carcinomas in relation to human papillomavirus infection and cytokinetics.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1997/08//
VL  - 26
IS  - 7
M3  - Article
SP  - 310
EP  - 314
SN  - 09042512
AB  - The numbers of argyrophilic nucleolar organizer regions (AgNORs) were quantified in oral carcinomas (<em>n</em>=39) with or without human papillomavirus (HPV) infection. The AgNOR counts of the HPV-positive samples (7.15±213) were not significantly (<em>P</em>=0.09) higher than those of the HPV-negative ones (6.16±1.89). Furthermore, the lesions infected with multiple HPV types had greater counts than those with HPV type 16/18 infection alone. Significant differences were observed between the mean counts of the poorly (10.50±0.54), moderately (7.31±1.07) and well- (5.12±0.85) differentiated carcinomas. The mean AgNOR numbers in the oral carcinomas at TNM stages III/IV were found to be significantly (<em>P</em><0.01) higher than the numbers in corresponding stage II lesions. Cytokinetics of the lesions assessed by the bromodeoxyuridine (Brdu) labelling index (LI%) showed a linear correlation (<em>r</em>=0.91; <em>P</em><0.0001) with their respective mean AgNOR counts. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PAPILLOMAVIRUSES
KW  - NUCLEOSIDES
KW  - BROMODEOXYURIDINE
KW  - ORAL cancer
KW  - URIDINE
KW  - ORAL hygiene
KW  - AgNORs
KW  - cytokinetics
KW  - HPV
KW  - nucleolar organizer regions
KW  - oral carcinoma
N1  - Accession Number: 13063241; Chatterjee, R. 1 Mukhopadhyay, D. 1 Chakraborty, R. N. 2 Mitra, R. Basu 3; Affiliation:  1: Department of tumor Virology, Chittaranjan National Cancer Institute, Calcutta, India.  2: Department of Pathology, Chittaranjan National Cancer Institute, Calcutta, India.  3: Department of Pathology, Institute of Postgraduate Medical Education and Research, Calcutta, India.; Source Info: Aug1997, Vol. 26 Issue 7, p310; Subject Term: PAPILLOMAVIRUSES; Subject Term: NUCLEOSIDES; Subject Term: BROMODEOXYURIDINE; Subject Term: ORAL cancer; Subject Term: URIDINE; Subject Term: ORAL hygiene; Author-Supplied Keyword: AgNORs; Author-Supplied Keyword: cytokinetics; Author-Supplied Keyword: HPV; Author-Supplied Keyword: nucleolar organizer regions; Author-Supplied Keyword: oral carcinoma; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1600-0714.ep13063241
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13063241&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107248535
T1  - A double-blind, placebo-controlled, randomized trial to evaluate the role of tetrachlorodecaoxide in the management of chemotherapy-induced oral mucositis... presented in part at the 11th Asia Pacific Cancer Conference, November 1993, Bangkok, Thailand.
AU  - Malik IA
AU  - Moid I
AU  - Haq S
AU  - Sabih M
Y1  - 1997/08//1997 Aug
N1  - Accession Number: 107248535. Language: English. Entry Date: 19980301. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. Grant Information: Brooks Pharmaceutical Company, Karachi, Pakistan. NLM UID: 8605836. 
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Stomatitis -- Chemically Induced
KW  - Stomatitis -- Drug Therapy
KW  - Mouth Mucosa -- Drug Effects
KW  - Chlorine -- Therapeutic Use
KW  - Oxides -- Therapeutic Use
KW  - Clinical Trials
KW  - Chi Square Test
KW  - Double-Blind Studies
KW  - Placebos
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 82
EP  - 87
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 14
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - We conducted a double-blind, placebo-controlled, randomized trial to evaluate the efficacy and safety of tetrachlorodecaoxide (TCDO) in patients with chemotherapy-induced mucositis. Sixty-two patients with World Health Organization grade II-IV oral mucositis were eligible for the study. They were randomized to receive TCDO or placebo, 10 ml, twice daily, swish and swallow, for 7 days. Patients were evaluated for oral pain, dysphagia, and oral intake. Downgrading and total duration of mucositis were documented. Thirty-two were randomized to receive TCDO. Thirty received the placebo. All were evaluable. Both arms were well matched for age, gender, type of underlying neoplasm, and prior history of oral mucositis. Intensity of initial symptoms, degree of mucositis, and time period between delivery of chemotherapy and development of mucositis were also similar. Post-therapy evaluation revealed no significant difference in the mean grade of oral and esophageal pain, or dysphagia between TCDO and placebo. Downgrading or total duration of mucositis did not differ between the two groups. Oral intake improved significantly in patients taking TCDO. Time to subjective improvement in oral pain was significantly shorter with TCDO (3.1 versus 3.6 days). Evaluation on day 3 revealed that 77% of those receiving TCDO were free of oral pain in comparison to 46% receiving placebo (P = 0.05). These results indicate that TCDO may be helpful in palliating some of the symptoms related to oral mucositis. The therapeutic benefit, however, is small and needs to be confirmed in a larger trial. (c) U.S. Cancer Pain Relief Committee, 1997 Published by Elsevier, New York, New York
SN  - 0885-3924
AD  - Division of Medical Oncology, National Cancer Institute, Clifton, Karachi, Pakistan
U2  - PMID: 9262037.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107248535&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107298134
T1  - Modifications in aerodynamic variables by persons who stutter under fluency-evoking conditions.
AU  - Stager SV
AU  - Denman DW
AU  - Ludlow CL
Y1  - 1997/08//
N1  - Accession Number: 107298134. Language: English. Entry Date: 19981201. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Stuttering Severity Instrument (Riley). NLM UID: 9705610. 
KW  - Fluency Disorders -- Diagnosis
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - National Institutes of Health (U.S.)
KW  - Severity of Illness Indices
KW  - Biophysical Instruments
KW  - Speech Production Measurement
KW  - Ventilation
KW  - Pretest-Posttest Design
KW  - Random Assignment
KW  - Data Analysis Software
KW  - Pressure
KW  - Descriptive Statistics
KW  - Analysis of Variance
KW  - Repeated Measures
KW  - Type I Error
KW  - Statistical Significance
KW  - P-Value
KW  - Time Factors
KW  - Regression
KW  - Human
SP  - 832
EP  - 847
JO  - Journal of Speech, Language & Hearing Research
JF  - Journal of Speech, Language & Hearing Research
JA  - JSLHR J SPEECH LANG HEAR RES
VL  - 40
IS  - 4
CY  - Rockville, Maryland
PB  - American Speech-Language-Hearing Association
AB  - The purposes of this study were to (a) compare the effects of fluency-evoking conditions on aerodynamic variables in 10 persons who stutter with those previously reported for 12 individuals who do not stutter; (b) determine if any changes demonstrated in the amplitude and/or timing of aerodynamic variables were accounted for by changes in speech intensity; and (c) determine if any amplitude or timing changes in flow and intraoral pressure were related to improved fluency. The fluency-evoking conditions were choral reading (CR), metronome-pacing (MET), delayed auditory feedback (DAF), and noise (NOISE). From 8 words beginning with plosive consonants in CVC contexts read aloud in sentences, measures were made of 8 variables, including closure duration, amplitude and time to maximum airflow and intraoral pressure for initial plosives, and the duration and intensity of the following vowel. Speech rate was also computed. Only fluently produced target words from persons who stutter were analyzed. All persons who stutter showed improved fluency under all conditions. Both groups demonstrated significant (p < or = 0.006) condition effects for peak flow, vowel intensity, and pressure rise time. Thus, fluency-evoking conditions affected these variables regardless of speaker type. Both groups changed peak pressure in similar directions from baseline depending on condition, but not significantly for each group in the same conditions. Persons who stutter significantly increased speech rate for CR, DAF, and NOISE; and persons who do not stutter significantly decreased rate under DAF. The reported changes in peak pressure and peak flow could not be accounted for by changes in vowel intensity. Larger improvements in fluency occurred under conditions when peak flow and peak pressure values were decreased from baseline. Thus, variables that were modified by both groups when speaking under conditions were also the variables related to changes in fluency for the persons who stutter.
SN  - 1092-4388
AD  - NIDCD, Building 10, Room 5N-118A, 10 Center Drive, MSC 1407, Bethesda, MD 20892-1407
U2  - PMID: 9263947.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107298134&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107282241
T1  - Clinical trial participant satisfaction: survey of SHEP enrollees... systolic hypertension in the Elderly Program.
AU  - Schron EB
AU  - Wassertheil-Smoller S
AU  - Pressel S
Y1  - 1997/08//8/ 1/1997
N1  - Accession Number: 107282241. Corporate Author: SHEP Cooperative Research Group. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Research Subjects
KW  - Patient Satisfaction
KW  - Clinical Trials
KW  - Data Analysis Software
KW  - Age Factors
KW  - Antihypertensive Agents -- Therapeutic Use
KW  - Attitude to Health
KW  - Whites
KW  - Double-Blind Studies
KW  - Educational Status
KW  - Health Resource Allocation
KW  - Hypertension -- Drug Therapy
KW  - Surveys
KW  - Interpersonal Relations
KW  - Minority Groups
KW  - Motivation
KW  - Blacks
KW  - Patient Selection
KW  - Placebos
KW  - Probability
KW  - Science
KW  - Sex Factors
KW  - Systole
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 934
EP  - 938
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVE: The purpose of this study was to determine older persons' reasons for joining a clinical trial, and to provide data that could be useful in planning and carrying out clinical trials in older and minority populations. DESIGN: A survey. PARTICIPANTS: The sample included 4281 men and women 60 years of age or older who were randomized to the Systolic Hypertension in the Elderly Program (SHEP). MEASUREMENTS: A 10-item satisfaction\attitude questionnaire was designed to evaluate (1) what personal benefits people expect from participation in this trial, (2) motivation for joining, and (3) satisfaction with clinic staff and operations. Each question had a response category asking for a measure of agreement, satisfaction, or importance. RESULTS: The most important reasons for joining the clinical trial were to contribute to science (96%), improve the health of others (96%), and improve their own health (93%). Free medical care and social aspects were less important reasons to join. There were no differences by treatment assignment, but differences in reasons for joining SHEP by age, race, gender, and education were observed. CONCLUSION: Older adults were enthusiastic about clinical trial participation. Recruitment, participant management strategies, and allocation of resources should consider the needs of specific patient groups.
SN  - 0002-8614
AD  - Clinical Trials Scientific Research Group, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, NIH, Two Rockledge Centre, Room 8144, 6701 Rockledge Drive MSC 7936, Bethesda, MD 20892-7936
U2  - PMID: 9256844.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107282241&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107237386
T1  - Comparison of sublingually and orally administered triazolam for premedication before oral surgery.
AU  - Berthold CW
AU  - Dionne RA
AU  - Corey SE
Y1  - 1997/08//1997 Aug
N1  - Accession Number: 107237386. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Digit Symbol Substitution Test (DSST). NLM UID: 101576782. 
KW  - Conscious Sedation -- Methods
KW  - Premedication
KW  - Triazolam -- Administration and Dosage
KW  - Dental Anxiety -- Evaluation
KW  - Pain Measurement
KW  - Tooth Extraction
KW  - Administration, Oral
KW  - Administration, Sublingual
KW  - Biological Availability
KW  - Triazolam -- Pharmacodynamics
KW  - Treatment Outcomes
KW  - Double-Blind Studies
KW  - Placebos
KW  - Comparative Studies
KW  - Chi Square Test
KW  - P-Value
KW  - Case Control Studies
KW  - Random Assignment
KW  - Visual Analog Scaling
KW  - Questionnaires
KW  - Repeated Measures
KW  - Scales
KW  - Kruskal-Wallis Test
KW  - Analysis of Variance
KW  - Male
KW  - Female
KW  - Adult
KW  - Human
SP  - 119
EP  - 124
JO  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JF  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JA  - ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDO
VL  - 84
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - OBJECTIVES: This study evaluated sublingual administration of triazolam for preoperative sedation in dental outpatients. STUDY DESIGN: A double-blind, placebo-controlled study compared 0.25 mg sublingual triazolam, 0.25 mg oral triazolam, and placebo administered 1 hour before oral surgery. RESULTS: Sublingual triazolam resulted in significantly less anxiety and pain at 15 minutes intraoperatively than both oral triazolam and placebo (p < 0.05). Patients' global evaluation of the efficacy of sedation ranked sublingual triazolam as significantly more efficacious than placebo (p < 0.05) with oral triazolam intermediate between the two. No difference was demonstrated in the rate of recovery or incidence of side effects between the two drug groups. Plasma triazolam levels were higher after sublingual administration during and after the surgical procedure. CONCLUSIONS: These results indicate that sublingual triazolam results in greater anxiolytic activity and less pain perception than oral administration as a result of greater plasma drug levels and may be useful as an alternative for nonparenteral outpatient sedation.
SN  - 1079-2104
AD  - National Institute of Dental Research, National Institutes of Health
U2  - PMID: 9269010.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107237386&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1997-05734-018
AN  - 1997-05734-018
AU  - Stager, Sheila V.
AU  - Denman, Daniel W.
AU  - Ludlow, Christy L.
T1  - Modifications in aerodynamic variables by persons who stutter under fluency-evoking conditions.
JF  - Journal of Speech, Language, and Hearing Research
JO  - Journal of Speech, Language, and Hearing Research
JA  - J Speech Lang Hear Res
Y1  - 1997/08//
VL  - 40
IS  - 4
SP  - 832
EP  - 847
CY  - US
PB  - American Speech-Language-Hearing Assn
SN  - 1092-4388
SN  - 1558-9102
N1  - Accession Number: 1997-05734-018. PMID: 9263947 Other Journal Title: Journal of Speech & Hearing Research. Partial author list: First Author & Affiliation: Stager, Sheila V.; National Insts of Health, NIDCD, Voice & Speech Section, Bethesda, MD, US. Release Date: 19970101. Correction Date: 20170309. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Speech Characteristics; Stuttering; Verbal Fluency. Minor Descriptor: Speech Rate. Classification: Speech & Language Disorders (3270). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. Page Count: 16. Issue Publication Date: Aug, 1997. 
AB  - Compared the effects of fluency-evoking conditions (FECs) on aerodynamic variables in 10 Ss (aged 22–52 yrs) who stutter with data previously reported for 12 Ss who do not stutter (S. V. Stager and C. L. Ludlow, 1993). The FECs were choral reading, metronome-pacing, delayed auditory feedback, and noise. Measures of 8 speech variables were made from 8 words beginning with plosive consonants read aloud in sentences. Results show that (1) peak flow, pressure rise time, and vowel intensity significantly differed from baseline depending on the particular FEC, but not speaker group; (2) peak pressure was modified in the same direction for speaking groups, but did not necessarily significantly differ from baseline under the same conditions for both groups; (3) changes in intensity did not account for the changes in intraoral pressure and airflow; (4) the greatest improvements in fluency occurred when Ss decreased peak pressure and flow; and (5) the degree to which a FEC affected peak flow was related to the degree to which fluency improved. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - fluency-evoking conditions
KW  - aerodynamic variables in speech
KW  - 22–52 yr old stutterers
KW  - comparison with data from adults with normal speech
KW  - 1997
KW  - Speech Characteristics
KW  - Stuttering
KW  - Verbal Fluency
KW  - Speech Rate
KW  - 1997
DO  - 10.1044/jslhr.4004.832
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-05734-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39706-010
AN  - 2015-39706-010
AU  - Sekiguchi, Masayuki
AU  - Fleck, Mark W.
AU  - Mayer, Mark L.
AU  - Takeo, Jiro
AU  - Chiba, Yoshiyuki
AU  - Yamashita, Shinya
AU  - Wada, Keiji
T1  - A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]- 2,6-difluoro-phenoxyacetamide.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/08//
VL  - 17
IS  - 15
SP  - 5760
EP  - 5771
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Sekiguchi, Masayuki, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Tokyo, Kodaira, Japan, 187
N1  - Accession Number: 2015-39706-010. PMID: 9221774 Partial author list: First Author & Affiliation: Sekiguchi, Masayuki; Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan. Release Date: 20160307. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Glutamate Receptors; Neural Receptors; AMPA. Minor Descriptor: Systematic Desensitization Therapy. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Aug, 1997. Publication History: Accepted Date: May 20, 1997; Revised Date: May 19, 1997; First Submitted Date: Mar 14, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - We report that a novel sulfonylamino compound, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide (PEPA), selectively potentiates glutamate receptors of the AMPA subtype. PEPA (1–200 μM) dose dependently potentiated glutamate-evoked currents in Xenopus oocytes expressing AMPA (GluRA–GluRD), but not kainate (GluR6 and GluR6 + KA2) or NMDA (ζ1 + ε1–ε4), receptor subunits. PEPA was effective at micromolar concentrations and, in contrast to the action of cyclothiazide, preferentially modulated AMPA receptor flop isoforms. At 200 μM, PEPA potentiated glutamate responses by 50-fold in oocytes expressing GluRCflop (EC₅₀ ∼50 μM) versus only threefold for GluRCflip; a similar preference for flop isoforms was observed for other AMPA receptor subunits. Dose–response analysis for GluRCflop revealed that 100 μM PEPA produced a sevenfold increase in AMPA receptor affinity for glutamate. PEPA produced considerably weaker potentiation of kainate-evoked than glutamate-evoked currents, suggesting modulation of the process of receptor desensitization. In human embryonic kidney 293 cells transfected with AMPA receptor subunits, PEPA either abolished or markedly slowed the rate of onset of desensitization and potentiated steady-state equilibrium currents evoked by glutamate with subunit (GluRC ≥ GluRD > GluRA) and splice-variant (flop > flip) selectivity similar to that observed in oocytes. Our results show that PEPA is a novel, flop-preferring allosteric modulator of AMPA receptor desensitization at least 100 times more potent than aniracetam. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptors
KW  - AMPA
KW  - desensitization
KW  - alternative splicing
KW  - flip and flop
KW  - allosteric modulation
KW  - 1997
KW  - Glutamate Receptors
KW  - Neural Receptors
KW  - AMPA
KW  - Systematic Desensitization Therapy
KW  - 1997
U1  - Sponsor: Ministry of Education, Science, Sports, and Culture. Recipients: No recipient indicated
U1  - Sponsor: Ministry of Health and Welfare. Recipients: No recipient indicated
U1  - Sponsor: Japan Science and Technology Agency, Japan. Recipients: No recipient indicated
U1  - Sponsor: Japan Foundation for Neuroscience and Mental Health, Japan. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Erman, B.
AU  - Bahar, I.
AU  - Jernigan, R. L.
T1  - Equilibrium states of rigid bodies with multiple interaction sites: Application to protein helices.
JO  - Journal of Chemical Physics
JF  - Journal of Chemical Physics
Y1  - 1997/08/08/
VL  - 107
IS  - 6
M3  - Article
SP  - 2046
EP  - 2059
PB  - American Institute of Physics
SN  - 00219606
AB  - Equilibrium configurations of rigid building blocks with multiple embedded interaction sites are investigated, as a coarse-grained approach for conformational sampling of protein structures with known secondary structure. First, hypothetical structures of asymmetric shapes, and pairs of rods composed of multiple interaction sites are considered. The rods are either disconnected or joined by a flexible loop. The sites are assumed to interact with a classical 6-12 Lennard-Jones potential. Subsequently, the investigation is extended to the study of two disconnected α helices composed of homogeneous interaction sites and to the ROP monomer, a small protein consisting of two heterogeneous α helices connected by a loop. Residue-specific long-range and short-range potentials extracted from a protein database are used. A Monte Carlo procedure combined with an energy minimization algorithm, originally developed by Li and Scheraga [Proc. Natl. Acad. Sci. USA 84, 6611 (1987)] is used to generate a set of low energy conformations over the full conformational space. Results show that: (i) The potential of mean force between two rods as a whole exhibits an inverse linear dependence on the separation between rods despite the individual sites interacting via a 6-12 Lennard-Jones potential. (ii) As the length of the rods (or helices) increases, they tend to align parallel to one other. (iii) This tendency to become parallel is enhanced when the density of interaction sites is higher. (iv) The angle between the principal axes of the rods is found to scale as n-5/3 with the number n of sites. (v) The native conformation of the ROP monomer, including the detailed rotational states of the virtual bonds located in the loop connecting the α helices is correctly predicted. This lends support to the adoption of such a coarse-grained model and its parameters for future simulations. © 1997 American Institute of Physics. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Chemical Physics is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EQUILIBRIUM
KW  - RIGID bodies (Mechanics)
KW  - PROTEINS
KW  - MONTE Carlo method
KW  - SIMULATION methods & models
N1  - Accession Number: 33899326; Erman, B. 1 Bahar, I. 1,2 Jernigan, R. L. 2; Affiliation:  1: Polymer Research Center, Bogazici University and TUBITAK Advanced Polymeric Materials Research Center, Bebek 80815, Istanbul, Turkey  2: Molecular Structure Section, Laboratory of Experimental and Computational Biology Division of Basic Sciences, National Cancer Institute, National Institutes of Health, MSC 5677, Room B-116, Bldg. 12B, Bethesda, Maryland 20892-5677; Source Info: 8/8/1997, Vol. 107 Issue 6, p2046; Subject Term: EQUILIBRIUM; Subject Term: RIGID bodies (Mechanics); Subject Term: PROTEINS; Subject Term: MONTE Carlo method; Subject Term: SIMULATION methods & models; Number of Pages: 14p; Illustrations: 3 Diagrams, 2 Charts, 7 Graphs; Document Type: Article
L3  - 10.1063/1.474555
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fuhrer, Christian
AU  - Sugiyama, Janice E.
AU  - Taylor, Robin G.
AU  - Hall, Zach W.
T1  - Association of muscle-specific kinase MuSK with the acetylcholine receptor in mammalian muscle.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/08/15/
VL  - 16
IS  - 16
M3  - Article
SP  - 4951
EP  - 4960
SN  - 02614189
AB  - During synaptogenesis at the neuromuscular junction, a neurally released factor, agrin, causes the clustering of acetylcholine receptors (AChRs) in the muscle membrane beneath the nerve terminal. Agrin acts through a specific receptor which is thought to have a receptor tyrosine kinase, MuSK, as one of its components. In agrin­treated muscle cells, both MuSK and the AChR become tyrosine phosphorylated. To determine how the activation of MuSK leads to AChR clustering, we have investigated their interaction in cultured C2 myotubes. Immunoprecipitation experiments showed that MuSK is associated with the AChR and that this association is increased by agrin treatment. Agrin also caused a transient activation of the AChR-associated MuSK, as demonstrated by MuSK phosphorylation. In agrin-treated myotubes, MuSK phosphorylation increased with the same time course as phosphorylation of the β subunit of the AChR, but declined more quickly. Although both herbimycin and staurosporine blocked agrin-induced AChR phosphorylation, only herbimycin inhibited the phosphorylation of MuSK. These results suggest that although agrin increases the amount of activated MuSK that is associated with the AChR, MuSK is not directly responsible for AChR phosphorylation but acts through other kinases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MYONEURAL junction
KW  - CHOLINERGIC receptors
KW  - PRECIPITATION (Chemistry)
KW  - PHOSPHORYLATION
KW  - acetylcholine receptor
KW  - agrin
KW  - muscle-specific kinase musk
KW  - neuromuscular junction
KW  - tyrosine phosphorylation
N1  - Accession Number: 13005682; Fuhrer, Christian 1 Sugiyama, Janice E. 1 Taylor, Robin G. 1 Hall, Zach W. 1; Email Address: hallz@nswide.ninds.nih.gov; Affiliation:  1: Section on Synaptic Mechanisms, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA; Source Info: 8/15/97, Vol. 16 Issue 16, p4951; Subject Term: MYONEURAL junction; Subject Term: CHOLINERGIC receptors; Subject Term: PRECIPITATION (Chemistry); Subject Term: PHOSPHORYLATION; Author-Supplied Keyword: acetylcholine receptor; Author-Supplied Keyword: agrin; Author-Supplied Keyword: muscle-specific kinase musk; Author-Supplied Keyword: neuromuscular junction; Author-Supplied Keyword: tyrosine phosphorylation; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/16.16.4951
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Koonin, Eugene V.
AU  - Mushegian, Arcady R.
AU  - Galperin, Michael Y.
AU  - Walker, D. Roland
T1  - Comparison of archaeal and bacterial genomes: computer analysis of protein sequences predicts novel functions and suggests a chimeric origin for the archaea.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997/08/15/
VL  - 25
IS  - 4
M3  - Article
SP  - 619
EP  - 637
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Protein sequences encoded in three complete bacterial genomes, those of <em>Haemophilus influenzae</em>, <em>Mycoplasma genitalium</em> and <em>Synechocystis</em> sp., and the first available archaeal genome sequence, that of <em>Methanococcus jannaschii</em>, were analysed using the BLAST2 algorithm and methods for amino acid motif detection. Between 75% and 90% of the predicted proteins encoded in each of the bacterial genomes and 73% of the <em>M. jannaschii</em> proteins showed significant sequence similarity to proteins from other species. The fraction of bacterial and archaeal proteins containing regions conserved over long phylogenetic distances is nearly the same and close to 70%. Functions of 70-85% of the bacterial proteins and about 70% of the archaeal proteins were predicted with varying precision. This contrasts with the previous report that more than half of the archaeal proteins have no homologues and shows that, with more sensitive methods and detailed analysis of conserved motifs, archaeal genomes become as amenable to meaningful interpretation by computer as bacterial genomes. The analysis of conserved motifs resulted in the prediction of a number of previously undetected functions of bacterial and archaeal proteins and in the identification of novel protein families. In spite of the generally high conservation of protein sequences, orthologues of 25% or less of the <em>M. jannaschii</em> genes were detected in each individual completely sequenced genome, supporting the uniqueness of archaea as a distinct domain of life. About 53% of the <em>M. jannaschii</em> proteins belong to families of paralogues, a fraction similar to that in bacteria with larger genomes, such as <em>Synechocystis</em> sp. and <em>Escherichia coli</em>, but higher than that in <em>H. influenzae</em>, which has approximately the same number of genes as <em>M. jannaschii</em>. Certain groups of proteins, e.g. molecular chaperones and DNA repair enzymes, thought to be ubiquitous and represented in the minimal gene set derived by bacterial genome comparison, are missing in <em>M. jannaschii</em>, indicating massive non-orthologous displacement of genes responsible for essential functions. An unexpectedly large fraction of the <em>M. jannaschii</em> gene products, 44%, shows significantly higher similarity to bacterial than to eukaryotic proteins, compared with 13% that have eukaryotic proteins as their closest homologues (the rest of the proteins show approximately the same level of similarity to bacterial and eukaryotic homologues or have no homologues). Proteins involved in translation, transcription, replication and protein secretion are most closely related to eukaryotic proteins, whereas metabolic enzymes, metabolite uptake systems, enzymes for cell wall biosynthesis and many uncharacterized proteins appear to be 'bacterial'. A similar prevalence of proteins of apparent bacterial origin was observed among the currently available sequences from the distantly related archaeal genus, <em>Sulfolobus</em>. It is likely that the evolution of archaea included at least one major merger between ancestral cells from the bacterial lineage and the lineage leading to the eukaryotic nucleocytoplasm. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Archaebacteria
KW  - Bacteria
KW  - Genomes
KW  - Amino acid sequence
KW  - Genes
KW  - Proteins
N1  - Accession Number: 21707615; Koonin, Eugene V. 1; Email Address: koonin@ncbi.nlm.nih.gov; Mushegian, Arcady R. 1,2; Galperin, Michael Y. 1; Walker, D. Roland 1,3; Affiliations: 1: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA; 2: Sequana Therapeutics, Inc., 11099 North Torrey Pines Rd., La Jolla, CA 92037, USA; 3: Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA; Issue Info: Aug1997, Vol. 25 Issue 4, p619; Thesaurus Term: Archaebacteria; Thesaurus Term: Bacteria; Subject Term: Genomes; Subject Term: Amino acid sequence; Subject Term: Genes; Subject Term: Proteins; Number of Pages: 19p; Illustrations: 2 Diagrams, 7 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105714837
T1  - CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
AU  - Hildesheim A
AU  - Anderson LM
AU  - Chen CJ
AU  - Cheng YJ
AU  - Brinton LA
AU  - Daly AK
AU  - Reed CD
AU  - Chen IH
AU  - Caporaso NE
AU  - Hsu MM
AU  - Chen JY
AU  - Idle JR
AU  - Hoover RN
AU  - Yang CS
AU  - Chhabra SK
Y1  - 1997/08/20/
N1  - Accession Number: 105714837. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Asians
KW  - Nasopharyngeal Neoplasms
KW  - Oxidoreductases
KW  - Polymorphism, Genetic
KW  - Adult
KW  - Aged
KW  - Ethanol -- Adverse Effects
KW  - Alleles
KW  - Carcinogens -- Adverse Effects
KW  - Case Control Studies
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Nitrosamines -- Adverse Effects
KW  - Questionnaires
KW  - Relative Risk
KW  - Risk Factors
KW  - Taiwan
KW  - Human
SP  - 1207
EP  - 1212
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 16
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. Hildesha@epndce.nci.nih.gov
U2  - PMID: 9274915.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107262057
T1  - Nurses of color -- a legacy of healing.
AU  - House K
Y1  - 1997/08/25/1997 Aug 25
N1  - Accession Number: 107262057. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; USA. NLM UID: 9421079. 
KW  - Blacks -- History -- United States
KW  - History of Nursing -- United States
KW  - United States
SP  - 12
EP  - 14
JO  - Nursing Spectrum -- Washington DC & Baltimore Edition
JF  - Nursing Spectrum -- Washington DC & Baltimore Edition
JA  - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL  - 7
IS  - 17
CY  - Falls Church, VA 22042, Illinois
PB  - Gannett Healthcare Group
SN  - 1098-9153
AD  - Georgetown University Surgical Services Department, National Institutes of Health, Bethesda, MD
U2  - PMID: 9439326.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105976081
T1  - Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.
AU  - McCann UD
AU  - Seiden LS
AU  - Rubin LJ
AU  - Ricaurte GA
AU  - McCann, U D
AU  - Seiden, L S
AU  - Rubin, L J
AU  - Ricaurte, G A
Y1  - 1997/08/27/
N1  - Accession Number: 105976081. Language: English. Entry Date: 20080215. Revision Date: 20161112. Publication Type: journal article; research; systematic review. Commentary: O'Callaghan J P, Miller D B. Brain serotonin neurotoxicity and fenfluramine and dexfenfluramine. (JAMA) 12/24/97-12/31/97; 278 (24): 2141-2142; Rothman R B. Brain serotonin neurotoxicity and fenfluramine and dexfenfluramine. (JAMA) 12/24/97-12/31/97; 278 (24): 2142-2142. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Appetite Depressants -- Adverse Effects
KW  - Biochemical Phenomena -- Drug Effects
KW  - Brain -- Drug Effects
KW  - Hypertension, Pulmonary -- Chemically Induced
KW  - Serotonin Uptake Inhibitors -- Adverse Effects
KW  - Serotonin -- Metabolism
KW  - Animals
KW  - Body Weight -- Drug Effects
KW  - Nerve Fibers -- Drug Effects
KW  - Animal Studies
SP  - 666
EP  - 672
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 278
IS  - 8
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objectives: Obesity is an important clinical problem, and the use of dexfenfluramine hydrochloride for weight reduction has been widely publicized since its approval by the Food and Drug Administration. However, animal and human studies have demonstrated toxic effects of fenfluramines that clinicians should be aware of when considering prescribing the drugs. Our purpose was to systematically review data on brain serotonin neurotoxicity in animals treated with fenfluramines and the evidence linking fenfluramines to primary pulmonary hypertension (PPH).Data Sources: Archival articles and reviews identified through a computerized search of MEDLINE from 1966 to April 1997 using "fenfluramine(s)," "serotonin," "neurotoxicity," "behavior," "anorexigens," "weight loss," and "primary pulmonary hypertension" as index terms.Study Selection: Reports dealing with long-term effects of fenfluramines on brain serotonin neurons, body weight, and pulmonary function in animals and humans.Data Extraction: Reports were reviewed by individuals with expertise in serotonin neurobiology, neurotoxicity, neuropsychiatry, and pulmonary medicine and evaluated for appropriateness for inclusion in this review.Data Synthesis: Fenfluramines cause dose-related, long-lasting reductions in serotonin axonal markers in all the animal species tested and with all the routes of drug administration used. Doses of fenfluramines that produce signs of brain serotonin neurotoxicity in animals are on the same order as those used to treat humans for weight loss when one takes into account known relations between body mass and drug clearance. However, no human studies have been conducted, and the pathological and clinical potential for neurotoxicity in humans is unknown. Appetite suppressants-most commonly fenfluramines-increase the risk of developing PPH (odds ratio, 6.3), particularly when used for more than 3 months (odds ratio, >20).Conclusions: Fenfluramine and dexfenfluramine have been demonstrated to damage brain serotonin neurons in animal studies. It is not known if such damage occurs in humans or if there are clinical consequences. Use of fenfluramines is associated with an increased risk of PPH. Future studies should address the long-term consequences of prolonged use of fenfluramines.
SN  - 0098-7484
AD  - Unit on Anxiety Disorders, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md 20892-1272, USA
U2  - PMID: 9272900.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Ernst, M
AU  - Zametkin, A J
AU  - Matochik, J A
AU  - Pascualvaca, D
AU  - Cohen, R M
T1  - Low medical prefrontal dopaminergic activity in autistic children.
JO  - Lancet
JF  - Lancet
Y1  - 1997/08/30/
VL  - 350
IS  - 9078
M3  - Article
SP  - 638
EP  - 670
PB  - Lancet
SN  - 00995355
AB  - Presents the results of a study which appear to implicate dopaminergic dysfunction as a cause for autism.  What dopamine does in the brain; The use of positron emission tomographic scanning (PET) to measure accumulation of flourine-18-labelled flourodopa (FDOPA); Findings; Conclusions.
KW  - AUTISM
KW  - DOPAMINERGIC mechanisms
N1  - Accession Number: 9708302697; Ernst, M 1 Zametkin, A J 2 Matochik, J A 2 Pascualvaca, D 2 Cohen, R M 2; Affiliation:  1: Brain Imaging Center, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD 21224, USA  2: Laboratory of Cerebral Metabolism. NIMH, NIH. Bethesda, MD. USA; Source Info: 8/30/1997, Vol. 350 Issue 9078, p638; Subject Term: AUTISM; Subject Term: DOPAMINERGIC mechanisms; Number of Pages: 1/2p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 677
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Suomi, Stephen J.
T1  - Transfer of tools and food between groups of tufted capuchins (Cebus apella ).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1997/09//
VL  - 43
IS  - 1
M3  - Article
SP  - 33
EP  - 41
SN  - 02752565
AB  - This research examined tool and food transfer between two groups of tufted capcuhin monkeys (Cebus apella ). Subjects in one group transferred stones to subjects in a second group who in turn used the stones as cutting tools and then transferred food to subjects in the first group. Aspects of the capuchins' behavior are similar to those described for food-sharing in Cebus, cooperative tool use in Papio, and tool and food exchange in Pan . We propose that tool use and food-sharing facilitate tool and food transfer between captive groups of Cebus apella. Am. J. Primatol. 43:33–41, 1997. © 1997 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CEBUS apella
KW  - CAPUCHIN monkeys
KW  - CEBIDAE
KW  - TOOL use in animals
KW  - ANIMAL intelligence
KW  - PRIMATE behavior
KW  - ANIMAL behavior
KW  - capuchin
KW  - cebus apella
KW  - cooperation
KW  - exchange
KW  - food-sharing
KW  - tool use
N1  - Accession Number: 12214626; Westergaard, Gregory Charles 1 Suomi, Stephen J. 1; Affiliation:  1: Laboratory of Comparative Ethology; National Institute of Child Health and Human Development, Poolesville, Maryland; Source Info: Sep97, Vol. 43 Issue 1, p33; Subject Term: CEBUS apella; Subject Term: CAPUCHIN monkeys; Subject Term: CEBIDAE; Subject Term: TOOL use in animals; Subject Term: ANIMAL intelligence; Subject Term: PRIMATE behavior; Subject Term: ANIMAL behavior; Author-Supplied Keyword: capuchin; Author-Supplied Keyword: cebus apella; Author-Supplied Keyword: cooperation; Author-Supplied Keyword: exchange; Author-Supplied Keyword: food-sharing; Author-Supplied Keyword: tool use; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Martin, Sandra L.
AU  - Kim, Haesook
AU  - Kupper, Lawrence L.
AU  - Meyer, Robert E.
AU  - Hays, Melissa
T1  - Is incarceration during pregnancy associated with infant birthweight?
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/09//
VL  - 87
IS  - 9
M3  - Article
SP  - 1526
EP  - 1531
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined whether incarceration during pregnancy is associated with infant birthweight. Methods. Multivariable analyses compared infant birthweight outcomes among three groups of women: 168 women incarcerated during pregnancy, 630 women incarcerated at a time other than during pregnancy, and 3910 women never incarcerated. Results. After confounders were controlled for, infant birthweights among women incarcerated during pregnancy were not significantly different from women never incarcerated; however, infant birthweights were significantly worse among women incarcerated at a time other than during pregnancy than among never-incarcerated women and women incarcerated during pregnancy. Conclusions. Certain aspects of the prison environment (shelter, food, etc.) may be health-promoting for high-risk pregnant women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMPRISONMENT
KW  - PREGNANCY
KW  - BIRTH weight
KW  - PRISON conditions
KW  - MULTIVARIATE analysis
N1  - Accession Number: 9710250215; Martin, Sandra L. 1 Kim, Haesook 2 Kupper, Lawrence L. 3 Meyer, Robert E. 4 Hays, Melissa 1; Affiliation:  1: Department of Maternal and Child Health, University of North Carolina, Chapel Hill  2: National Institute of Child Health and Development, National Institutes of Health, Rockville, Md.  3: Department of Biostatistics, University of North Carolina Chapel Hill  4: Department of Environment, Health and Natural Resources, NC State Center for Health and Statistics, Raleigh, NC; Source Info: Sep97, Vol. 87 Issue 9, p1526; Subject Term: IMPRISONMENT; Subject Term: PREGNANCY; Subject Term: BIRTH weight; Subject Term: PRISON conditions; Subject Term: MULTIVARIATE analysis; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 5103
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Issaragrisil, Surapol
AU  - Chansung, Kanchana
AU  - Kaufman, David W.
AU  - Sirijirachai, Jittima
AU  - Thamprasit, Tharatorn
AU  - Young, Neal S.
T1  - Aplastic anemia in rural Thailand: Its association with grain farming and agricultural pesticide exposure.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1997/09//
VL  - 87
IS  - 9
M3  - Article
SP  - 1551
EP  - 1554
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. A population-based case-control study was conducted to elucidate the incidence and etiology of aplastic anemia in Thailand. Methods. Case patients and hospital control patients were enrolled in three regions from 1989 to 1994; data were collected by interview. Results. Forty-six percent of 81 case patients and 19% of 295 control patients from Khonkaen were grain farmers (estimated relative risk [RR] = 2.7. 95% confidence interval [CI] = 1.4, 5.2). Sixteen percent of case patients and 6% of control patients used agricultural pesticides (estimated RR = 2.7, 95% CI = 1.1, 6.6). The association with grain farming remained among those not exposed to pesticides. In Songkla, 16% of 43 case patients and 2% of 181 control patients were grain farmers (crude RR estimate = 11, 95% CI = 3.4,35). Conclusions. The relation of aplastic anemia to grain fanning may partly explain the high incidence of aplastic anemia in Thailand. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APLASTIC anemia
KW  - DISEASES -- Causes & theories of causation
KW  - FARMERS
KW  - PESTICIDES
KW  - THAILAND
N1  - Accession Number: 9710250221; Issaragrisil, Surapol 1 Chansung, Kanchana 2 Kaufman, David W. 3 Sirijirachai, Jittima 2 Thamprasit, Tharatorn 4 Young, Neal S. 5; Affiliation:  1: Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand  2: Department of Medicine, Faculty of Medicine, Khonkaen University, Khonkaen, Thailand  3: Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, Mass.  4: Department of Medicine, Faculty of Medicine, Prince of Songkla University, Songkla, Thailand  5: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md.; Source Info: Sep97, Vol. 87 Issue 9, p1551; Subject Term: APLASTIC anemia; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: FARMERS; Subject Term: PESTICIDES; Subject Term: THAILAND; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2601
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107182915
T1  - Quality of life and breast cancer survivors: psychosocial and treatment issues.
AU  - Lee CO
Y1  - 1997/09//1997 Sep-Oct
N1  - Accession Number: 107182915. Language: English. Entry Date: 19990501. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. Instrumentation: Ferrans and Powers Quality of Life Index - Cancer Version. NLM UID: 9312355. 
KW  - Breast Neoplasms -- Psychosocial Factors
KW  - Quality of Life
KW  - Support, Psychosocial
KW  - Cancer Survivors -- Psychosocial Factors
KW  - Ferrans and Powers Quality of Life Index
KW  - Psychological Tests
KW  - Descriptive Statistics
KW  - Content Validity
KW  - Internal Consistency
KW  - P-Value
KW  - Volunteer Workers -- Psychosocial Factors
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 309
EP  - 316
JO  - Cancer Practice
JF  - Cancer Practice
JA  - CANCER PRACT
VL  - 5
IS  - 5
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - PURPOSE: This study was conducted to determine the relationship between social support, extent of breast cancer surgery, length of time since surgery, geographic location, and overall quality of life (QOL) in breast cancer survivors. Additionally, the motivational factors for survivors to volunteer in a community rehabilitation program were assessed. DESCRIPTION OF STUDY: A convenience sample of 134 survivors who had undergone mastectomies were invited to participate. Study packets including an information letter, a demographic sheet, and Ferrans and Powers Quality of Life-Cancer Version questionnaire were mailed. The return of completed forms was considered consent. RESULTS: The sample (N = 100) consisted mostly of married women (75%) who had surgery a mean of 14 years previously. Findings indicated that there is no correlation between marital status and the number or type of support persons and overall QOL. Interestingly, unmarried women were found to have a better perceived QOL than married women, although the difference was not statistically significant. There was no significant difference between extent of surgery, length of time since surgery, and geographic location with overall QOL. Thematic analysis of motivation to volunteer revealed an underlying theme of helping with sharing knowledge/providing information and giving emotional support for all age groups. Other themes were personal gain; giving back to the program, others, and God; and assisting others in avoiding a negative experience. CLINICAL IMPLICATIONS: Quality of life is a dynamic, multifaceted process through which perceptions, viewpoints, and behaviors change as a result of the various experiences throughout the survival period. These findings demonstrate that social support plays a vital role in promoting overall QOL in breast cancer survivors. The development of supportive behaviors by healthcare providers and Reach for Recovery volunteers is essential in providing this social support for breast cancer survivors. Growth in understanding and relieving the psychological stress that new cancer survivors endure is an area that warrants particular attention. Additionally, these participants indicated their need and willingness to share their experiences. Support is needed to provide survivors with the opportunity to function as volunteers. Program developers and evaluators must work together to ensure this support on a consistent basis.
SN  - 1065-4704
AD  - National Institutes of Health, National Cancer Institute, Inpatient Medical Oncology, Bethesda, MD
U2  - PMID: 9341354.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Melnick, Ronald L.
AU  - Kohn, Michael C.
AU  - Huff, James
T1  - Weight of Evidence Versus Weight of Speculation to Evaluate the α 2u-Globulin.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1997/09//
VL  - 105
IS  - 9
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Presents the experimental evidence of the hypothesis that α 2u-globulin protein accumulation, has a relationship with nephrocarcinogenesis. Drug, which is used to induce 2u-globulin protein in the body; Role of lindane, in inducing kidney tumors in rats; Mechanisms, by which tumors appear in the kidneys of male rats.
KW  - Lindane
KW  - Alpha globulins
KW  - Globulins -- Therapeutic use
KW  - Proteins
KW  - Drugs -- Effectiveness
KW  - Kidneys -- Cancer -- Treatment
KW  - Rats as laboratory animals
N1  - Accession Number: 13013346; Melnick, Ronald L. 1; Kohn, Michael C. 1; Huff, James 1; Affiliations: 1: National Institute of Environmental Health Sciences Research Triangle Park, North Carolina,; Issue Info: Sep1997, Vol. 105 Issue 9, p1; Thesaurus Term: Lindane; Subject Term: Alpha globulins; Subject Term: Globulins -- Therapeutic use; Subject Term: Proteins; Subject Term: Drugs -- Effectiveness; Subject Term: Kidneys -- Cancer -- Treatment; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107235351
T1  - Organisation of services. Video communication and palliative care at home.
AU  - De Conno F
AU  - Martini C
Y1  - 1997/09//1997 Sep-Oct
N1  - Accession Number: 107235351. Language: English. Entry Date: 19980101. Revision Date: 20150820. Publication Type: Journal Article; pictorial. Journal Subset: Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9434451. 
KW  - Telemedicine -- Methods -- Italy
KW  - Cancer Patients
KW  - Videorecording
KW  - Computers and Computerization
KW  - Communication
KW  - Multidisciplinary Care Team
KW  - Palliative Care
KW  - Clinical Assessment Tools
KW  - Patient Assessment
KW  - Italy
SP  - 174
EP  - 177
JO  - European Journal of Palliative Care
JF  - European Journal of Palliative Care
JA  - EUR J PALLIAT CARE
VL  - 4
IS  - 5
PB  - Hayward Medical Communications
AB  - Franco De Conno and Cinzia Martini outline their current research project into the uses of video technology to support patients who are dying at home and their families.
SN  - 1352-2779
AD  - Director, Division of Rehabilitation, Pain Therapy and Palliative Care, National Cancer Institute, Milan, Italy
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107235353
T1  - Special feature. The development of the European Association for Palliative Care.
AU  - Blumhuber H
AU  - De Conno F
AU  - Vanegas G
Y1  - 1997/09//1997 Sep-Oct
N1  - Accession Number: 107235353. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9434451. 
KW  - Palliative Care -- Organizations
KW  - Congresses and Conferences
SP  - 178
EP  - 181
JO  - European Journal of Palliative Care
JF  - European Journal of Palliative Care
JA  - EUR J PALLIAT CARE
VL  - 4
IS  - 5
PB  - Hayward Medical Communications
AB  - Heidi Blumhuber, Franco De Conno and Guillermo Vanegas outline the history and development of the European Association for Palliative Care (EAPC).
SN  - 1352-2779
AD  - Executive Officer, EAPC Head Office, National Cancer Institute, Milan, Italy
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bolon, Brad
AU  - Bucci, Thomas J.
AU  - Warbritton, Alan R.
AU  - Chen, James J.
AU  - Mattison, Donald R.
AU  - Heindel, Jerrold J.
T1  - Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/09//
VL  - 39
IS  - 1
M3  - Article
SP  - 1
EP  - 10
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Ovaries from National Toxicology Program Reproductive Assessment by Continuous Breeding (RACB) bioassays were used to directly compare differential ovarian follicle counts and reproductive performance for 15 chemicals. Ovaries of 10 animals per group from 16 studies in CD-1 mice and 1 study each in C3H and C57BL/6 mice were sectioned serially at 6 μm. Counts of small, growing, and antral follicles were obtained in every 10th section. For all follicle types, younger mice had more follicles than older mice, and CD-1 mice had more follicles than age-matched animals from either inbred strain. The in-life portion of the RACB protocols demonstrated that 9 of 15 chemicals altered reproductive outcome in one or both sexes of mice, with six agents affecting females (R. E. Morrissey et al., 1989, Furuiam. Appl Toxicol 13, 747–777). Three of six female toxicants [ 2,2-bis(bromoethyl)-1,3-Propanediol, BPD; ethylene glycol monomethyl ether, EGME; methoxyacetic acid, MAA] significantly decreased counts of small and/or growing follicles by 33 to 92% In CD-1 mice; EGME also reduced follicle counts in the other strains. Follicle counts were decreased in progeny of animals treated with EGME or its active metabolite, MAA. For BPD, reductions in follicle numbers were proportional to dose. In CD-1 mice, female toxicants di-N-hexyl phthalate, propantheline bromide, and tricresyl phosphate reduced reproductive performance but not follicle numbers. Counts were not affected by toxicants for which the susceptible sex could not be determined (bisphenol A, ethylene glycol, oxalic acid). Altered follicle counts without apparent reproductive impairment occurred in CD-1 mice at lower doses of BPD but were not observed for nontoxic chemicals. These data suggest that differential follicle counts (1) are a quantifiable endpoint of ovarian injury in conventional bioassays, and (2) in some instances, may provide a more sensitive indicator of female reproductive toxicity than fertility. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Biological assay
KW  - Toxicology
KW  - Follicle-stimulating hormone
KW  - Mice as laboratory animals
KW  - Bromides
N1  - Accession Number: 82413025; Bolon, Brad 1; Bucci, Thomas J. 1; Warbritton, Alan R. 1; Chen, James J. 2; Mattison, Donald R. 2; Heindel, Jerrold J. 3; Affiliations: 1: Pathology Associates International (an SAIC Company) Jefferson, Arkansas 72079; 2: † Biometry and Risk Assessment Division, National Center for Toxicological Research Jefferson, Arkansas 72079; 3: ‡ Developmental and Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; Issue Info: 1997, Vol. 39 Issue 1, p1; Thesaurus Term: Biological assay; Thesaurus Term: Toxicology; Subject Term: Follicle-stimulating hormone; Subject Term: Mice as laboratory animals; Subject Term: Bromides; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Shkarin, Pavel
AU  - Spencer, Richard G. S.
T1  - Time domain simulation of Fourier imaging by summation of isochromats.
JO  - International Journal of Imaging Systems & Technology
JF  - International Journal of Imaging Systems & Technology
Y1  - 1997/09//
VL  - 8
IS  - 5
M3  - Article
SP  - 419
EP  - 426
SN  - 08999457
AB  - We have developed a time-domain simulation of two-dimensional Fourier imaging in which the signal is represented by a finite Fourier series. Each term corresponds to a spin isochromat and has a coefficient that evolves in response to radiofrequency and gradient pulses, and periods of free precession. An explicit calculation is performed to derive the number of isochromats required to achieve a specified degree of precision, permitting accurate results to be obtained in an efficient fashion. With this, the time-domain signal throughout the entire experiment is calculated. The resulting time domain data is combined into the standard k-space matrix and yields an image after two-dimensional Fourier transformation. Multiple-shot sequences such as spin warp and single-shot experiments such as Burst are simulated in the same fashion. Our procedure makes no assumptions about transverse dephasing between pulses, so that complicated sequences of direct and stimulated echoes are correctly modeled. The influence of spin-spin and spin-lattice relaxation is included in a natural way. A number of artifacts can be quantitatively reproduced. © 1997 John Wiley & Sons, Inc. Int J Imaging Syst Technol, 8, 419–426, 1997 [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Imaging Systems & Technology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SIMULATION methods & models
KW  - RADIO frequency
KW  - MAGNETIC resonance imaging
KW  - MAGNETIZATION
N1  - Accession Number: 13509826; Shkarin, Pavel 1 Spencer, Richard G. S. 1; Affiliation:  1: National Institutes of Health, National Institute on Aging, 4940 Eastern Avenue, Baltimore, MD 21224; Source Info: Sep97, Vol. 8 Issue 5, p419; Subject Term: SIMULATION methods & models; Subject Term: RADIO frequency; Subject Term: MAGNETIC resonance imaging; Subject Term: MAGNETIZATION; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 8p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Valdez, Avelardo
AU  - Sifaneck, Stephen J.
T1  - DRUG TOURISTS AND DRUG POLICY ON THE U.S.-MEXICAN BORDER: AN ETHNOGRAPHIC INVESTIGATION OF THE ACQUISITION OF PRESCRIPTION DRUGS.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1997///Fall97
VL  - 27
IS  - 4
M3  - Article
SP  - 879
EP  - 897
SN  - 00220426
AB  - Recent increases in the prevalence of non-medical prescription drug use across the United States have prompted national concern about the sources of these drugs. The focus of this study is the process by which prescription drugs enter the United States from Mexico through "drug tourism." Drug tourism refers to the phenomenon by which persons become attracted to a particular location because of the accessibility of licit or illicit drugs and related services. A loophole in U.S. Customs laws enables Americans to legally bring pharmaceutical drugs into the United States when accompanied by a Mexican prescription. Using ethnographic field methods, this study (1) describes the acquisition process, (2) develops a typology of consumers, and (3) explores the interaction between the actors in this process. This study provides a better understanding of the social dynamics of a "gray market" in prescription drugs, and identifies a hidden population of drug users. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG laws & regulations
KW  - TOURISM
KW  - BOUNDARIES
KW  - PHARMACEUTICAL policy
KW  - UNITED States
KW  - MEXICO
N1  - Accession Number: 22873; Valdez, Avelardo 1,2 Sifaneck, Stephen J. 3; Affiliation:  1: Associate Professor of Sociology, University of Texas, San Antonio  2: Director, Hispanic Research Center  3: Principal Investigator of two National Institute on Drug Abuse (NIDA), South Texas; Source Info: Fall97, Vol. 27 Issue 4, p879; Subject Term: DRUG laws & regulations; Subject Term: TOURISM; Subject Term: BOUNDARIES; Subject Term: PHARMACEUTICAL policy; Subject Term: UNITED States; Subject Term: MEXICO; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 561591 Convention and Visitors Bureaus; NAICS/Industry Codes: 721214 Recreational and Vacation Camps (except Campgrounds); NAICS/Industry Codes: 721211 RV (Recreational Vehicle) Parks and Campgrounds; NAICS/Industry Codes: 721199 All Other Traveler Accommodation; NAICS/Industry Codes: 721191 Bed-and-Breakfast Inns; NAICS/Industry Codes: 721120 Casino Hotels; NAICS/Industry Codes: 721110 Hotels (except Casino Hotels) and Motels; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; Number of Pages: 19p; Document Type: Article; Full Text Word Count: 9347
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107245031
T1  - Practice points: translating research into practice. Breaking down the barriers to healthful eating.
AU  - Nebeling LC
Y1  - 1997/09//
N1  - Accession Number: 107245031. Language: English. Entry Date: 19980301. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Nutrition Education
KW  - National Cancer Institute (U.S.)
SP  - 965
EP  - 965
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
IS  - 9
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107245068
T1  - Changes in carotenoid intake in the United States: the 1987 and 1992 National Health Interview Surveys.
AU  - Nebeling LC
AU  - Forman MR
AU  - Graubard BI
AU  - Snyder RA
Y1  - 1997/09//
N1  - Accession Number: 107245068. Language: English. Entry Date: 19980301. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Carotenoids -- Administration and Dosage
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Multiple Linear Regression
KW  - Descriptive Statistics
KW  - Questionnaires
KW  - Chi Square Test
KW  - T-Tests
KW  - Female
KW  - Male
KW  - Fruit
KW  - Vegetables
KW  - Sex Factors
KW  - Blacks
KW  - Whites
KW  - Survey Research
KW  - Human
SP  - 991
EP  - 996
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
IS  - 9
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - National Cancer Institute, EPN 211, 6130 Executive Blvd, MSC 7326, Bethesda, MD
U2  - PMID: 9284877.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107304134
T1  - Methodology and feasibility of a home-based examination in disabled older women: the Women's Health and Aging Study.
AU  - Simonsick EM
AU  - Maffeo CE
AU  - Rogers SK
AU  - Skinner EA
AU  - Davis D
AU  - Guralnik JM
AU  - Fried LP
Y1  - 1997/09//
N1  - Accession Number: 107304134. Corporate Author: Johns Hopkins University Medical Institutions, Baltimore. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al); Purdue Pegboard. NLM UID: 9502837. 
KW  - Disabled
KW  - Physical Examination
KW  - Women's Health
KW  - Activities of Daily Living
KW  - Aged
KW  - Body Weights and Measures
KW  - Female
KW  - Health Screening
KW  - Human
KW  - Interviews
KW  - Maryland
KW  - Medicare
KW  - Nurses
KW  - Nursing Assessment
KW  - Physical Examination -- Equipment and Supplies
KW  - Prospective Studies
KW  - Psychological Tests
KW  - Questionnaires
KW  - Research Subjects -- Economics
KW  - Stratified Random Sample
SP  - M264
EP  - 74
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 52A
IS  - 5
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Gateway Building Suite 3C-309, Bethesda MD 20892
U2  - PMID: 9310080.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107304140
T1  - Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women's Health and Aging Study.
AU  - Ferrucci L
AU  - Guralnik JM
AU  - Buchner D
AU  - Kasper J
AU  - Lamb SE
AU  - Simionsick EM
AU  - Corti MC
AU  - Bandeen-Roche K
AU  - Fried LP
Y1  - 1997/09//
N1  - Accession Number: 107304140. Corporate Author: Women's Health and Aging Study Research Group. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 9502837. 
KW  - Leg -- Physiology
KW  - Muscle, Skeletal -- Physiology
KW  - Women's Health
KW  - Activities of Daily Living
KW  - Aged
KW  - Aged, 80 and Over
KW  - Analysis of Variance
KW  - Biophysiological Methods
KW  - Chi Square Test
KW  - Confidence Intervals
KW  - Correlation Coefficient
KW  - Data Analysis Software
KW  - Dependent Variable
KW  - Descriptive Statistics
KW  - Hip -- Physiology
KW  - Human
KW  - Independent Variable
KW  - Interviews
KW  - Knee -- Physiology
KW  - Linear Regression
KW  - Male
KW  - Maryland
KW  - Medicare
KW  - Nurses
KW  - Odds Ratio
KW  - P-Value
KW  - Physical Examination
KW  - Prospective Studies
KW  - Psychological Tests
KW  - Self Report
KW  - Stratified Random Sample
SP  - M275
EP  - 85
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 52A
IS  - 5
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C-309, Bethesda, MD 20892
U2  - PMID: 9310081.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Eckert, Inge
AU  - Caspary, William J.
AU  - Nüsse, Michael
AU  - Liechty, Melissa
AU  - Davis, Lisa
AU  - Stopper, Helga
T1  - Micronuclei containing whole chromosomes harbouring the selectable gene do not lead to mutagenesis.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1997/09//
VL  - 12
IS  - 5
M3  - Article
SP  - 379
EP  - 382
PB  - Oxford University Press / USA
SN  - 02678357
AB  - Loss of heterozygosity is one genetic change observed in many tumours. We do not know whether the loss of chromosomal material through micronucleus formation is a viable mechanism associated with, and possibly leading to, genetic disease. Previously, we treated L5178Y mouse lymphoma cells with four aneugens. Although these aneugens induced micronuclei containing predominantly whole chromosomes, they did not induce mutations at Tk1, the selectable gene, under the same non-toxic conditions in which they induced micronuclei. This suggested that the induction of micronuclei containing whole chromosomes was not an early event leading to phenotypically expressed mutations in these cells under the conditions used. However, it is possible that chromosome 11, on which Tk1 resides, may be under-represented in the micronucleus population. To find out the frequency of induction of micronuclei containing chromosome 11, we applied fluorescence in situ hybridization using a chromosome 11 paint to micronuclei induced by colcemid and vinblastine. We found that the numbers of micronuclei containing chromosome 11 are more than sufficient to be detectable as mutations if these micronuclei lead to viable mutants. We conclude that the formation of micronuclei containing whole chromosomes does not lead to viable, dividing mutants in this system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutation (Biology)
KW  - Cell nuclei
KW  - Chromosomes
KW  - Mutagenesis
KW  - Genetic disorders
KW  - Lymphomas
KW  - Mice as laboratory animals
N1  - Accession Number: 79237900; Eckert, Inge 1; Caspary, William J. 2; Nüsse, Michael 3; Liechty, Melissa 4; Davis, Lisa 4; Stopper, Helga 1; Affiliations: 1: Department of Toxicology, University of Wurzburg 97078 Wurzburg, Germany; 2: National Institutes of Health. Research Triangle Park NC 27709, USA; 3: GSF-Flow Cytometry 85764 Neuherberg, Germany; 4: Applied Genetics Laboratories Inc. 1335 Gateway Drive, Melbourne, FL 32901, USA; Issue Info: Sep1997, Vol. 12 Issue 5, p379; Thesaurus Term: Mutation (Biology); Subject Term: Cell nuclei; Subject Term: Chromosomes; Subject Term: Mutagenesis; Subject Term: Genetic disorders; Subject Term: Lymphomas; Subject Term: Mice as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
AU  - Stayner, Leslie
AU  - Smith, Randall
AU  - Bailer, John
AU  - Gilbert, Stephen
AU  - Steenland, Kyle
AU  - Dement, John
AU  - Brown, David
AU  - Lemen, Richard
T1  - Exposure-response analysis or risk of respiratory disease associated with occupational exposure to chrysotile asbestos.
JO  - Occupational & Environmental Medicine
JF  - Occupational & Environmental Medicine
Y1  - 1997/09//
VL  - 54
IS  - 9
M3  - Article
SP  - 646
EP  - 652
SN  - 13510711
AB  - Objectives: To evaluate alternative models and estimate risk of mortality from lung cancer and asbestosis after occupational exposure to chrysotile asbestos. Methods: Data were used from a recent update of a cohort mortality study of workers in a South Carolina textile factory. Alternative exposure-response models were evaluated with Poisson regression. A model designed to evaluate evidence of a threshold response was also fitted. Lifetime risks of lung cancer and asbestosis were estimated with an actuarial approach that accounts for competing causes of death. Results: A highly significant exposure-response relation was found for both lung cancer and asbestosis. The exposure-response relation for lung cancer seemed to be linear on a multiplicative scale, which is consistent with previous analyses of lung cancer and exposure to asbestos. In contrast, the exposure-response relation for asbestosis seemed to be nonlinear on a multiplicative scale in this analysis. There was no significant evidence for a threshold in models of either the lung cancer or asbestosis. The excess lifetime risk for white men exposed for 45 years at the recently revised OSHA standard of 0.1 fibre/ml was predicted to be about 5/1000 for lung cancer, and 2/1000 for asbestosis. Conclusions: This study confirms the findings from previous investigations of a strong exposure-response relation between exposure to chrysotile asbestos and mortality from lung cancer, and asbestosis. The risk estimates for lung cancer derived from this analysis are higher than those derived from other populations exposed to chrysotile asbestos. Possible reasons for this discrepancy are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epidemiology
KW  - Risk assessment
KW  - Threshold limit values (Industrial toxicology)
KW  - Asbestos -- Health aspects
KW  - Lungs -- Cancer -- Patients
KW  - chrysotile asbestos
KW  - epidemiology
KW  - risk assessment
N1  - Accession Number: 8002977; Stayner, Leslie 1; Smith, Randall 1; Bailer, John 1,2; Gilbert, Stephen 1; Steenland, Kyle 1; Dement, John 3; Brown, David 4; Lemen, Richard 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio 45226, USA; 2: Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056, USA; 3: Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA; 4: National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, USA; Issue Info: Sep1997, Vol. 54 Issue 9, p646; Thesaurus Term: Epidemiology; Thesaurus Term: Risk assessment; Thesaurus Term: Threshold limit values (Industrial toxicology); Thesaurus Term: Asbestos -- Health aspects; Subject Term: Lungs -- Cancer -- Patients; Author-Supplied Keyword: chrysotile asbestos; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: risk assessment; Number of Pages: 7p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3  - 10.1136/oem.54.9.646
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8002977&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Vaughan, Thomas L.
AU  - Stewart, Patricia A.
AU  - Davis, Scott
AU  - Thomas, David B.
AU  - Vaughan, T L
AU  - Stewart, P A
AU  - Davis, S
AU  - Thomas, D B
T1  - Work in dry cleaning and the incidence of cancer of the oral cavity, larynx, and oesophagus.
JO  - Occupational & Environmental Medicine
JF  - Occupational & Environmental Medicine
Y1  - 1997/09//
VL  - 54
IS  - 9
M3  - journal article
SP  - 692
EP  - 695
SN  - 13510711
AB  - <bold>Objectives: </bold>To investigate whether employment in dry cleaning, and potential exposure to perchloroethylene (PCE), were associated with increased risk of carcinoma of the oral cavity and pharynx, larynx, oesophagus, and gastric cardia.<bold>Methods: </bold>Two population based case-control studies were carried out. There were 491 cases of carcinoma of the oral cavity and pharynx, 235 of the larynx, and 404 of the oesophagus and gastric cardia. 724 controls were selected by random digit dialing. Personal interviews ascertained information on lifetime job histories, cigarette use, alcohol consumption, and other potential risk factors. The probability and level of exposure to PCE were estimated from the scientific literature.<bold>Results: </bold>People who worked in dry cleaning tended to consume less alcohol and cigarettes than the general population. The adjusted odds ratio (OR) associated with ever having worked in dry cleaning was 1.6 (95% confidence interval (95% CI) = 0.6 to 4.4) for all cancer types together. The strongest associations were with laryngeal (OR 2.7; 95% CI 0.6 to 10.9) and oesophageal squamous cell carcinomas (OR 3.6; 95% CI 0.5 to 27.0). For laryngeal cancer, the relative risk increased with number of years employed in the dry cleaning industry (P = 0.14. The two cases of oesophageal squamous cell carcinomas had worked in dry cleaning for only a short time. Analyses of subsites showed higher risks for supraglottic laryngeal cancer (OR 5.7; 95% CI 1.0 to 32.1) and cancer of the tongue (OR 2.3; 95% CI 0.4 to 12.6). Analyses of exposure to PCE yielded similar results.<bold>Conclusions: </bold>These findings could easily be explained by chance; nevertheless, they are consistent with previous reports of excess risk of oesophageal, laryngeal, and tongue cancer, and suggest that previous studies of dry cleaners that could not control for alcohol and cigarette use may have underestimated the relative risks of such cancers. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Tetrachloroethylene
KW  - Threshold limit values (Industrial toxicology)
KW  - Cancer
KW  - Dry cleaning
KW  - Esophagus
KW  - Larynx
KW  - adenocarcinoma
KW  - dry cleaning
KW  - gastric cardia
KW  - larynx
KW  - neoplasms
KW  - oesophageal
KW  - oral cavity
KW  - perchloroethylene
N1  - Accession Number: 8002990; Vaughan, Thomas L. 1; Stewart, Patricia A. 2; Davis, Scott 1; Thomas, David B. 1; Vaughan, T L 3; Stewart, P A; Davis, S; Thomas, D B; Affiliations: 1: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA and Department of Epidemiology, University of Washington, Seattle, WA; 2: Epidemiology and Biostatistics Program, National Cancer Institute, Rockville, MD; 3: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA; Issue Info: Sep1997, Vol. 54 Issue 9, p692; Thesaurus Term: Tetrachloroethylene; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Cancer; Subject Term: Dry cleaning; Subject Term: Esophagus; Subject Term: Larynx; Author-Supplied Keyword: adenocarcinoma; Author-Supplied Keyword: dry cleaning; Author-Supplied Keyword: gastric cardia; Author-Supplied Keyword: larynx; Author-Supplied Keyword: neoplasms; Author-Supplied Keyword: oesophageal; Author-Supplied Keyword: oral cavity; Author-Supplied Keyword: perchloroethylene; NAICS/Industry Codes: 812310 Coin-Operated Laundries and Drycleaners; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: journal article
L3  - 10.1136/oem.54.9.692
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8002990&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107255461
T1  - Mood disorders: occupational therapy intervention.
AU  - Robertson SC
Y1  - 1997/09//1997 Sep
N1  - Accession Number: 107255461. Language: English. Entry Date: 19980501. Revision Date: 20150820. Publication Type: Journal Article; diagnostic images. Journal Subset: Allied Health; USA. NLM UID: 9602488. 
KW  - Depression -- Therapy
KW  - Bipolar Disorder -- Therapy
KW  - Occupational Therapy
KW  - National Institutes of Health (U.S.)
KW  - Research Subjects
SP  - 34
EP  - 39
JO  - OT Practice
JF  - OT Practice
JA  - OT PRACT
VL  - 2
IS  - 9
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
AB  - Recognizing the close link between psychiatry and occupational therapy, says Susan C. Robertson, can both clarify the biological bases of human behavior and enrich treatment options for patients with mental illnesses.
SN  - 1084-4902
AD  - National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107203254
T1  - Food intakes of US children and adolescents compared with recommendations.
AU  - Munoz KA
AU  - Krebs-Smith SM
AU  - Ballard-Barbash R
AU  - Cleveland LE
Y1  - 1997/09//Sept97 Part 1 of 2
N1  - Accession Number: 107203254. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Sept97 Part 1 of 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422. 
KW  - Dietary Reference Intakes
KW  - Eating
KW  - Adolescence
KW  - Child
KW  - Child, Preschool
KW  - Data Analysis Software
KW  - Diet Records
KW  - Energy Intake
KW  - Female
KW  - Food Habits
KW  - Human
KW  - Macronutrients
KW  - Male
KW  - Micronutrients
SP  - 323
EP  - 329
JO  - Pediatrics
JF  - Pediatrics
JA  - PEDIATRICS
VL  - 100
IS  - 3
CY  - Chicago, Illinois
PB  - American Academy of Pediatrics
SN  - 0031-4005
AD  - Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 9282700.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107203254&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105824351
T1  - Identification of suicide risk factors using epidemiologic studies.
AU  - Moscicki EK
Y1  - 1997/09//1997 Sep
N1  - Accession Number: 105824351. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Suicide Intent Scale. NLM UID: 7708110. 
KW  - Suicide
KW  - Adolescence
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Cause of Death
KW  - Child
KW  - Female
KW  - Life Change Events
KW  - Male
KW  - Mental Disorders -- Mortality
KW  - Mental Disorders -- Psychosocial Factors
KW  - Middle Age
KW  - Relative Risk
KW  - Scales
KW  - Substance Use Disorders -- Mortality
KW  - Substance Use Disorders -- Psychosocial Factors
KW  - Suicide -- Psychosocial Factors
KW  - Suicide, Attempted -- Psychosocial Factors
KW  - Suicide, Attempted
KW  - United States
KW  - Human
SP  - 499
EP  - 517
JO  - Psychiatric Clinics of North America
JF  - Psychiatric Clinics of North America
JA  - PSYCHIATR CLIN NORTH AM
VL  - 20
IS  - 3
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Suicide is a complex outcome of multiple, inter-related factors. This article presents the epidemiology of completed and attempted suicide and discusses the known risk factors for suicide within a framework designed to encourage a systematic approach to theory testing and prevention. Mental and addictive disorders, frequently in co-occurrence, are the most powerful risk factors for suicide in all age groups, accounting for over 90 percent of all completed suicides. In combination with proximal risk factors such as access to firearms or other lethal means, recent and severe stressful life events, and intoxication, they can form the necessary and sufficient conditions for suicide.Copyright © 1997 by Elsevier Inc.
SN  - 0193-953X
AD  - Prevention and Behavioral Medicine Research Branch, National Institute of Mental Health, National Institutes of Health, Rockville, Maryland, USA.
U2  - PMID: 9323310.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105824351&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Morasso, Gabriella
AU  - Alberisio, Alessandra
AU  - Capelli, Marco
AU  - Rossi, Cristiana
AU  - Baracco, Gloria
AU  - Costantini, Massimo
T1  - Illness Awareness in Cancer Patients: A Conceptual Framework And A Preliminary Classification Hypothesis.
JO  - Psycho-Oncology
JF  - Psycho-Oncology
Y1  - 1997/09//
VL  - 6
IS  - 3
M3  - Article
SP  - 212
EP  - 217
PB  - John Wiley & Sons, Inc.
SN  - 10579249
AB  - The study describes the initial phases of research aimed at developing a methodology for assessing awareness in cancer patients. A first sample of cancer patients (n = 36) was interviewed about their knowledge of the diagnosis and their perception of treatment goals and outcomes. Thirteen domains which refer both to cognitive and emotional areas were identified, and considered as content valid by a panel of six experts. A second sample of patients (n = 54) participated in a semi-structured interview developed to explore awareness by means of the domains identified. Seven patterns of awareness were identified, ranging from ‘completely aware patient’ to ‘completely unaware patient’. Twenty of the 54 patients (37.0%) were completely aware, 19 (35.2%) were partially aware with defence mechanisms and 15 (27.8%) were not aware of their diagnosis. Patients from the National Cancer Institute were more frequently aware (54.3%) compared with the patients interviewed in the community hospitals (5.3%) (p <0.001). A computerized content analysis allowed the identification of two main groups of patients on the basis of the content of the recorded interviews. This independent classification agreed with the classification of the patients performed by the psychologists, suggesting the validity of the procedure of awareness evaluation proposed in this study. © 1997 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psycho-Oncology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER patients
KW  - AWARENESS
KW  - CANCER -- Diagnosis
KW  - HOSPITAL care
KW  - DECISION making in clinical medicine
KW  - PREVENTIVE medicine
N1  - Accession Number: 11819112; Morasso, Gabriella 1 Alberisio, Alessandra 1 Capelli, Marco 1 Rossi, Cristiana 1 Baracco, Gloria 1 Costantini, Massimo 2; Affiliation:  1: Psychology Service, National Cancer Institute, Genova, Italy.  2: Unit of Clinical Epidemiology and Trials, National Cancer Institute, Genova, Italy.; Source Info: Sep1997, Vol. 6 Issue 3, p212; Subject Term: CANCER patients; Subject Term: AWARENESS; Subject Term: CANCER -- Diagnosis; Subject Term: HOSPITAL care; Subject Term: DECISION making in clinical medicine; Subject Term: PREVENTIVE medicine; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107236477
T1  - Illness awareness in cancer patients: a conceptual framework and a preliminary classification hypothesis.
AU  - Morasso G
AU  - Alberisio A
AU  - Capelli M
AU  - Rossi C
AU  - Baracco G
AU  - Costantini M
Y1  - 1997/09//
N1  - Accession Number: 107236477. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: This work was supported in part by P.F. CNR ACRO. NLM UID: 9214524. 
KW  - Cancer Patients -- Psychosocial Factors
KW  - Health Knowledge
KW  - Cognition
KW  - Descriptive Statistics
KW  - Semi-Structured Interview
KW  - Content Analysis
KW  - Italy
KW  - Content Validity
KW  - Audiorecording
KW  - Data Analysis Software
KW  - Cluster Analysis
KW  - Kappa Statistic
KW  - Conceptual Framework
KW  - Hypothesis
KW  - Cognition -- Evaluation
KW  - Coding
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 212
EP  - 217
JO  - Psycho-Oncology
JF  - Psycho-Oncology
JA  - PSYCHO ONCOL
VL  - 6
IS  - 3
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
SN  - 1057-9249
AD  - Psychology Service, National Cancer Institute, Genova, Italy
U2  - PMID: 9313287.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107236477&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107160086
T1  - The effect of Medicare reimbursement for screening mammography on utilization and payment.
AU  - Breen N
AU  - Fewer EJ
AU  - Depuy S
AU  - Zapka J
Y1  - 1997/09//Sep/Oct97
N1  - Accession Number: 107160086. Corporate Author: National Cancer Institute. Breast Cancer Screening Consortium. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - Medicare
KW  - Insurance, Health, Reimbursement
KW  - Mammography -- Utilization
KW  - Mammography -- Economics
KW  - Health Education
KW  - Case Control Studies
KW  - Comparative Studies
KW  - Surveys
KW  - Cross Sectional Studies
KW  - Interviews
KW  - Chi Square Test
KW  - Descriptive Statistics
KW  - P-Value
KW  - Self Report
KW  - Confidence Intervals
KW  - Breast Neoplasms -- Prevention and Control
KW  - Socioeconomic Factors
KW  - Educational Status
KW  - Aged
KW  - Female
KW  - Human
SP  - 423
EP  - 432
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 112
IS  - 5
PB  - Sage Publications Inc.
AB  - Objective. In January 1991, Medicare extended its mammography benefit to reimburse for breast cancer screening mammograms. In 199 1 and again in 1993, the National Cancer Institute Breast Cancer Screening Consortium (BCSC) conducted a survey to test the hypothesis that this benefit would increase mammography use among women over the age of 65. Methods. The authors analyzed data on non-Hispanic white women ages 65 to 74 living in I I geographic areas targeted by the BCSC for an earlier study-six that had received cancer screening educational interventions and five control subsites-to measure the impact of the newly adopted Medicare benefit on the use of mammography and use of Medicare to reimburse mammography costs. Results. The data show little overall increase between 199 1 and 1993 in reported mammography use among respondents to the survey. However, in six intervention and five control subsites there was an increase in the percentage of women who reported using public payment sources to at least partially reimburse the cost of mammograms. In three intervention subsites, the increase from 1991 to 1993 in the percentage of women using public sources of payment was greater than in the corresponding control subsites. Conclusions. These findings suggest that public health interventions are more likely to succeed when educational promotion accompanies a financial benefit.
SN  - 0033-3549
AD  - Applied Research Branch, NCI/NIH, EPN 313, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892-7344; email: nb19k@nih.gov
U2  - PMID: 9323395.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107160086&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00285-001
AN  - 2006-00285-001
AU  - Wassermann, Eric M.
AU  - Grafman, Jordan
T1  - Combining transcranial magnetic stimulation and neuroimaging to map the brain.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1997/09//
VL  - 1
IS  - 6
SP  - 199
EP  - 200
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Wassermann, Eric M., Cognitive Neuroscience Section, Medical Neurology Branch, NINDS, Bethesda, MD, US, 20892-1428
N1  - Accession Number: 2006-00285-001. PMID: 21223902 Partial author list: First Author & Affiliation: Wassermann, Eric M.; Office of the Clinical Director, Medical Neurology Branch, NINDS, Bethesda, MD, US. Release Date: 20061204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Brain; Stereotaxic Atlas; Tomography; Transcranial Magnetic Stimulation. Classification: Electrophysiology (2530). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Sep, 1997. 
AB  - Comments on an article by T. Paus et al. (1997). Transcranial magnetic stimulation (TMS) is a noninvasive technique for focal activation of the cortex. The stimulation is generally quite tolerable, but can be painful. T. Paus and colleagues reported the use of positron emission tomography (PET) to demonstrate transsynaptic activation of the parietal eye-movement area with rTMS of the frontal eye fields. This long-awaited technical advance probably will be a significant contribution to solving the problem of how TMS affects brain activity, as well other questions in human neurophysiology. One of the important advantages of combining TMS with PET is the possibility of evaluating neurophysiological effects of TMS in other than motor regions. The authors present their work as the mapping the structural connectivity of the human brain, one which does not suffer from the problems of interpretation inherent in functional imaging studies where the brain is activated by a behavioral paradigm. Although TMS-activated PET is free of some of the difficulties of behaviorally activated studies, it is far more complex than injecting an anterograde neuronal tracer into the brain of an animal. Even with robust designs, such as the parametric model appropriately employed by the authors, it could be perilous for investigators to ignore the mental state of their subjects during the experiment. Clearly, this is not a major consideration for a study on the outflow of the frontal eye field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - transcranial magnetic stimulation
KW  - brain mapping
KW  - PET
KW  - 1997
KW  - Brain
KW  - Stereotaxic Atlas
KW  - Tomography
KW  - Transcranial Magnetic Stimulation
KW  - 1997
DO  - 10.1016/S1364-6613(97)01069-3
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00285-001&site=ehost-live&scope=site
UR  - wassermann@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-42931-004
AN  - 1997-42931-004
AU  - Verhagen Metman, L.
AU  - van den Munckhof, P.
AU  - Klaassen, A. A. G.
AU  - Blanchet, P.
AU  - Mouradian, M. M.
AU  - Chase, T. N.
T1  - Effects of supra-threshold levodopa doses on dyskinesias in advanced Parkinson's disease.
JF  - Neurology
JO  - Neurology
Y1  - 1997/09//
VL  - 49
IS  - 3
SP  - 711
EP  - 713
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0028-3878
SN  - 1526-632X
N1  - Accession Number: 1997-42931-004. Partial author list: First Author & Affiliation: Verhagen Metman, L.; National Institutes of Health, National Inst of Neurological Disorders & Stroke, Experimental Therapeutics Branch, Bethesda, MD, US. Release Date: 19980201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dosages; Drug Therapy; Levodopa; Parkinson's Disease. Minor Descriptor: Dyskinesia. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 3. Issue Publication Date: Sep, 1997. 
AB  - The levodopa (LD) dose-antiparkinsonian response relationship becomes progressively steeper with advancing Parkinson's disease (PD). To establish the dose-response profile for the dyskinesiogenic effect of LD, the authors administered iv LD over a wide dose range to 25 patients (aged 45–77 yrs) with advanced PD. As expected in these patients with nonexistent therapeutic windows, the threshold doses for both motor effects were similar. Just around the therapeutic dose, the relationship between LD dose and the magnitude of antiparkinsonian and dyskinesiogenic responses inclined steeply, reaching a plateau above 1.5 × therapeutic dose. Response duration, however, continued to increase. Results suggest that attempts to ameliorate dyskinesias in advanced PD patients by giving smaller, more frequent LD doses may be counterproductive due to shorter motor responses, more 'off' time, and dose failures, while some may, in fact, benefit from higher LD doses to assure a full response and prolong its duration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dose response profiles for antiparkinsonian & dyskinesiogenic effects of levodopa
KW  - 45–77 yr olds with Parkinson's disease
KW  - 1997
KW  - Drug Dosages
KW  - Drug Therapy
KW  - Levodopa
KW  - Parkinson's Disease
KW  - Dyskinesia
KW  - 1997
DO  - 10.1212/WNL.49.3.711
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-42931-004&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13563-011
AN  - 2008-13563-011
AU  - Hashimoto, Kenji
AU  - Tomitaka, Shin-ichiro
AU  - Bi, Ying
AU  - Narita, Natsuko
AU  - Minabe, Yoshio
AU  - lyo, Masaomi
T1  - Rolipram, a selective phosphodiesterase type-IV inhibitor, prevents induction of heat shock protein HSP-70 and hsp-70 mRNA in rat retrosplenial cortex by the NMDA receptor antagonist dizocilpine.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1997/09//
VL  - 9
IS  - 9
SP  - 1891
EP  - 1901
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Hashimoto, Kenji, Division of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
N1  - Accession Number: 2008-13563-011. PMID: 9383212 Partial author list: First Author & Affiliation: Hashimoto, Kenji; Division of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. Other Publishers: Blackwell Publishing. Release Date: 20081006. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Hashimoto, Kenji. Major Descriptor: Cerebral Cortex; Genes; N-Methyl-D-Aspartate; Neurotoxicity; Proteins. Minor Descriptor: Rats; Microglia; Phosphodiesterase. Classification: Psychopharmacology (2580). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Sep, 1997. 
AB  - The non-competitive NMDA receptor antagonists, such as (+)-MK-801 (dizocilpine), cause the expression of heat shock protein HSP-70 and pathomorphological damage in the retrosplenial cortex of the rat brain. However, the precise mechanism(s) underlying the neurotoxicity of NMDA receptor antagonists is unknown. The present study was undertaken to examine the role of phosphodiesterase type IV in the expression of heat shock genes induced by dizocilpine. Heat shock protein HSP-70, which is known as a sensitive marker of neuron injury, was induced in the retrosplenial cortex of the rat brain 24 h after a single administration of dizocilpine (1 mg/kg). Pretreatment with the specific phosphodiesterase type IV inhibitor rolipram (2.5, 5 or 10 mg/kg, 15 min before dizocilpine) attenuated the expression of HSP-70 and hsp-70 mRNA induced by dizocilpine (1 mg/kg) in a dose-dependent manner. Furthermore, another phosphodiesterase type IV inhibitor, Ro 20-1724 (5 or 10 mg/kg, 15 min before dizocilpine), and a non-selective phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX) (5 or 10 mg/kg, 15 min before dizocilpine), significantly attenuated the expression of HSP-70 protein and hsp-70 mRNA induced in the retrosplenial cortex by dizocilpine. However, the induction of the immediate early gene c-fos and microglial activation in the retrosplenial cortex after administration of dizocilpine was not attenuated by pretreatment with rolipram (5 or 10 mg/kg, 15 min before dizocilpine). Moreover, histopathological study indicated that pretreatment with rolipram (5 or 10 mg/kg, 15 min before dizocilpine) did not prevent the formation of vacuoles caused by treatment with dizocilpine. The present findings suggest that phosphodiesterase type IV may play a significant role in the expression of HSP-70 protein and hsp-70 mRNA in the rat retrosplenial cortex after administration of dizocilpine, and that phosphodiesterase type IV may not play a role in the neurotoxicity of NMDA receptor antagonists such as dizocilpine. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - immediate early genes
KW  - microglia activation
KW  - neurotoxicity
KW  - phencyclidine
KW  - phosphodiesterase type IV
KW  - rolipram
KW  - heat shock protein
KW  - retrosplenial cortex
KW  - dizocilpine
KW  - rats
KW  - 1997
KW  - Cerebral Cortex
KW  - Genes
KW  - N-Methyl-D-Aspartate
KW  - Neurotoxicity
KW  - Proteins
KW  - Rats
KW  - Microglia
KW  - Phosphodiesterase
KW  - 1997
U1  - Sponsor: Ministry of Health and Welfare. Recipients: No recipient indicated
U1  - Sponsor: Research Development Corporation of Japan, Japan. Recipients: Hashimoto, Kenji
DO  - 10.1111/j.1460-9568.1997.tb00756.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13563-011&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39784-027
AN  - 2015-39784-027
AU  - Betarbet, Ranjita
AU  - Turner, Robert
AU  - Chockkan, Vijay
AU  - DeLong, Mahlon R.
AU  - Allers, Kelly A.
AU  - Walters, Judith
AU  - Levey, Allan I.
AU  - Greenamyre, J. Timothy
T1  - Dopaminergic neurons intrinsic to the primate striatum.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/09//
VL  - 17
IS  - 17
SP  - 6761
EP  - 6768
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Greenamyre, J. Timothy, Department of Neurology, Emory University, 1639 Pierce Drive, WMB 6000, Atlanta, GA, US, 30322
N1  - Accession Number: 2015-39784-027. PMID: 9254687 Partial author list: First Author & Affiliation: Betarbet, Ranjita; Department of Neurology, Emory University, Atlanta, GA, US. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Greenamyre, J. Timothy. Major Descriptor: Animal Models; Dopamine; Striatum; Interneurons; Bipolar Cells. Minor Descriptor: Neurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 1997. Publication History: Accepted Date: Jun 11, 1997; Revised Date: Jun 4, 1997; First Submitted Date: Apr 21, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys; TH-i cell counts, however, were 3.5-fold higher in the striatum of MPTP-lesioned monkeys. To establish the dopaminergic nature of the TH-i cells, sections were double-labeled with antibodies to dopamine transporter (DAT). Immunofluorescence studies demonstrated that nearly all TH-i cells were double-labeled with DAT, suggesting that they contain the machinery to be functional dopaminergic neurons. Two types of TH-i cells were identified in the striatum: small, aspiny, bipolar cells with varicose dendrites and larger spiny, multipolar cells. The aspiny cells, which were more prevalent, corresponded morphologically to the GABAergic interneurons of the striatum. Double-label immunofluorescence studies using antibodies to TH and glutamate decarboxylase (GAD₆₇), the synthetic enzyme for GABA, showed that 99% of the TH-i cells were GAD₆₇-positive. Very few (< 1%) of the TH-i cells, however, were immunoreactive for the calcium-binding proteins calbindin and parvalbumin. In summary, these results demonstrate that the dopaminergic cell population of the striatum responds to dopamine denervation by increasing in number, apparently to compensate for loss of extrinsic dopaminergic innervation. Moreover, this population of cells corresponds largely with the intrinsic GABAergic cells of the striatum. This study also suggests that the adult primate striatum does retain some intrinsic capacity to compensate for dopaminergic cell loss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - striatum
KW  - dopaminergic cells
KW  - Parkinson’s disease-treated monkeys
KW  - dopamine transporter
KW  - glutamic acid decarboxylase
KW  - calbindin
KW  - parvalbumin
KW  - 1997
KW  - Animal Models
KW  - Dopamine
KW  - Striatum
KW  - Interneurons
KW  - Bipolar Cells
KW  - Neurons
KW  - 1997
U1  - Sponsor: United States Public Health Service. Grant: NS33779. Recipients: Greenamyre, J. Timothy
U1  - Sponsor: United States Public Health Service. Grant: NS31937. Recipients: Levey, Allan I.; DeLong, Mahlon R.
U1  - Sponsor: Sponsor name not included. Other Details: Mallinckrodt Scholar Award. Recipients: Greenamyre, J. Timothy
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39784-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39784-031
AN  - 2015-39784-031
AU  - Kreiss, Deborah S.
AU  - Mastropietro, Christopher W.
AU  - Rawji, Saima S.
AU  - Walters, Judith R.
T1  - The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson’s disease.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/09//
VL  - 17
IS  - 17
SP  - 6807
EP  - 6819
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Walters, Judith R., National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10/5C- 103, 9000 Rockville Pike, Bethesda, MD, US, 20892-1406
N1  - Accession Number: 2015-39784-031. PMID: 9254691 Partial author list: First Author & Affiliation: Kreiss, Deborah S.; Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Neural Receptors; Subthalamic Nucleus. Minor Descriptor: Parkinson's Disease; Rats. Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Sep, 1997. Publication History: Accepted Date: Jun 17, 1997; Revised Date: Jun 2, 1997; First Submitted Date: Feb 10, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Overactivity in the subthalamic nucleus (STN) is believed to contribute to the pathophysiology of Parkinson’s disease. It is hypothesized that dopamine receptor agonists reduce neuronal output from the STN. The present study tests this hypothesis by using in vivo extracellular single unit recording techniques to measure neuronal activity in the STN of rats with 6-hydroxydopamine-induced lesions of the nigrostriatal pathway (a model of Parkinson’s disease). As predicted, firing rates of STN neurons in lesioned rats were tonically elevated under basal conditions and were decreased by the nonselective dopamine receptor agonists apomorphine and L-3,4-dihydroxyphenylalanine (L-DOPA). STN firing rates were also decreased by the D2 receptor agonist quinpirole when administered after the D1 receptor agonist (±)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol (SKF 38393). Results of the present study challenge the prediction that dopaminergic agonists reduce STN activity predominantly through actions at striatal dopamine D2 receptors. Firing rates of STN neurons were not altered by selective stimulation of D2 receptors and were increased by selective stimulation of D1 receptors. Moreover, there was a striking difference between the responses of the STN to D1/D2 receptor stimulation in the lesioned and intact rat; apomorphine inhibited STN firing in the lesioned rat and increased STN firing in the intact rat. These findings support the premise that therapeutic efficacy in the treatment of Parkinson’s disease is associated with a decrease in the activity of the STN, but challenge assumptions about the roles of D1 and D2 receptors in the regulation of neuronal activity of the STN in both the intact and dopamine-depleted states. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - L-3
KW  - 4-dihydroxyphenylalanine
KW  - apomorphine
KW  - 6-hydroxydopamine
KW  - (6)-1-phenyl-2
KW  - 3
KW  - 4
KW  - 5-tetrahydro-(1H)-3- benzazepine-7
KW  - 8-diol
KW  - quinpirole
KW  - haloperidol
KW  - dopamine
KW  - D1 receptor
KW  - D2 receptor
KW  - subthalamic nucleus
KW  - Parkinson’s disease
KW  - basal ganglia
KW  - electrophysiology
KW  - burst analysis
KW  - firing pattern
KW  - 1997
KW  - Dopamine
KW  - Neural Receptors
KW  - Subthalamic Nucleus
KW  - Parkinson's Disease
KW  - Rats
KW  - 1997
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39784-031&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39787-006
AN  - 2015-39787-006
AU  - Xu, Ren-He
AU  - Kim, Jaebong
AU  - Taira, Masanori
AU  - Sredni, Dvora
AU  - Kung, Hsiang-fu
T1  - Studies on the role of fibroblast growth factor signaling in neurogenesis using conjugated/aged animal caps and dorsal ectoderm-grafted embryos.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/09//
VL  - 17
IS  - 18
SP  - 6892
EP  - 6898
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Kung, Hsiang-fu, Laboratory of Biochemical Physiology, Building 567, Room 152, Frederick, MD, US, 21702-1201
N1  - Accession Number: 2015-39787-006. PMID: 9278524 Partial author list: First Author & Affiliation: Xu, Ren-He; Intramural Research Support Program, Science Applications International Corporation–Frederick, MD, US. Release Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Embryo; Cell Signaling; Neurogenesis; Growth Factor. Minor Descriptor: Calcium; Frogs; Neural Receptors. Classification: Psychopharmacology (2580). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 1997. Publication History: Accepted Date: Jul 1, 1997; Revised Date: Jun 19, 1997; First Submitted Date: Jan 28, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Basic fibroblast growth factor (bFGF) has been shown to induce neural fate in dissociated animal cap (AC) cells or in AC explants cultured in low calcium and magnesium concentrations. However, long-term disclosure of the cap may cause diffusion of the secreted molecule bone morphogenetic protein 4 (BMP-4), a neural inhibitor present in the AC. This may contribute to the subsequent neurogenesis induced by bFGF. Here we used conjugated and aged blastula AC to avoid diffusion of endogenous molecules from the AC. Unlike noggin, bFGF failed to induce neural tissue in this system. However, it enhanced neuralization elicited by a dominant negative BMP receptor (DN-BR) that inhibits the BMP-4 signaling. Posterior neural markers were turned on by bFGF in AC expressing DN-BR or chordin. Blocking the endogenous FGF signal with a dominant negative FGF receptor (XFD) mainly inhibited development of posterior neural tissue in neuralized ACs. These in vitro studies were confirmed invivo in embryos grafted with XFD-expressing ACs in the place of neuroectoderm. Expression of some regional neural markers was inhibited, although markers for muscle and posterior notochord were still detectable in the grafted embryos, suggesting that XFD specifically affected neurogenesis but not the dorsal mesoderm. The use of these in vitro and in vivo model systems provides new evidence that FGF, although unable to initiate neurogenesis on its own, is required for neural induction as well as for posteriorization. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - FGF
KW  - BMP
KW  - neurogenesis
KW  - anteroposterior patterning
KW  - Xenopus
KW  - embryo
KW  - 1997
KW  - Embryo
KW  - Cell Signaling
KW  - Neurogenesis
KW  - Growth Factor
KW  - Calcium
KW  - Frogs
KW  - Neural Receptors
KW  - 1997
U1  - Sponsor: Bar Ilan University, Shiffman Program for Clinical and Basic Research, Israel. Recipients: No recipient indicated
U1  - Sponsor: National Cancer Institute, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39787-006&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39787-007
AN  - 2015-39787-007
AU  - Nirenberg, Melissa J.
AU  - Chan, June
AU  - Pohorille, Roxanne A.
AU  - Vaughan, Roxanne A.
AU  - Uhl, George R.
AU  - Kuhar, Michael J.
AU  - Pickel, Virginia M.
T1  - The dopamine transporter: Comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/09//
VL  - 17
IS  - 18
SP  - 6899
EP  - 6907
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Nirenberg, Melissa J., Department of Neurology and Neuroscience, Cornell University Medical College, 411 East 69th Street, Room KB-410, New York, NY, US, 10021
N1  - Accession Number: 2015-39787-007. PMID: 9278525 Partial author list: First Author & Affiliation: Nirenberg, Melissa J.; Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY, US. Release Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Nirenberg, Melissa J. Major Descriptor: Axons; Dopamine; Nucleus Accumbens. Minor Descriptor: Motor Processes; Rats; Immunocytochemistry. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 1997. Publication History: Accepted Date: Jul 1, 1997; Revised Date: Jul 1, 1997; First Submitted Date: May 5, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The dopamine transporter (DAT) regulates extracellular dopamine concentrations, transports neurotoxins, and acts as a substrate for cocaine reinforcement. These functions are known to differ in the limbic-associated shell and motor-associated core compartments of the nucleus accumbens (NAc). Previous studies have shown differential expression of DAT in the NAc shell and core but were limited in resolution to the regional level. Thus, it is not known whether there are differences in the amount, subcellular localization, or plasmalemmal targeting of DAT within individual dopaminergic axons in the two regions. We used high-resolution electron microscopic immunocytochemistry to investigate these possibilities. We show that in both the shell and core, DAT immunogold labeling is present in tyrosine hydroxylase-immunoreactive varicose axons that form symmetric synapses. Within these labeled axons, most DAT gold particles are located on extrasynaptic plasma membranes, but some are associated with intracellular membranes. Dopaminergic axons in the shell contain lower mean densities of both total DAT gold particles (per square micron) and plasmalemmal DAT gold particles (per micron) than those in the core. Within labeled axons in the NAc shell and core, however, there are no detectable differences in the subcellullar distribution of DAT or the percentage of total DAT gold particles that are located on plasma membranes. These studies are the first to examine and compare the subcellular localization of DAT in the NAc shell and core. As a result, they identify intrinsic, cell-specific differences in the expression of DAT within dopaminergic axons in these functionally distinct striatal compartments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - dopamine transporter
KW  - dopamine reuptake
KW  - immunogold
KW  - accumbens
KW  - striatum
KW  - cocaine
KW  - amphetamine
KW  - 1997
KW  - Axons
KW  - Dopamine
KW  - Nucleus Accumbens
KW  - Motor Processes
KW  - Rats
KW  - Immunocytochemistry
KW  - 1997
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH40342. Recipients: Nirenberg, Melissa J.; Pickel, Virginia M.
U1  - Sponsor: National Institute of Mental Health, US. Grant: MH00078. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, US. Grant: DA04600. Recipients: Pickel, Virginia M.
U1  - Sponsor: National Institute on Drug Abuse, Intramural Research Program, US. Recipients: Vaughan, Roxanne A.; Uhl, George R.
U1  - Sponsor: National Institutes of Health, US. Grant: RR00165. Recipients: Kuhar, Michael J.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39787-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105819618
T1  - AIDS buyers' clubs.
AU  - DeChristoforo R
AU  - Minor JR
Y1  - 1997/09/15/1997 Sep 15
N1  - Accession Number: 105819618. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023. 
KW  - Acquired Immunodeficiency Syndrome -- Drug Therapy
KW  - Acquired Immunodeficiency Syndrome -- Economics
KW  - Antiviral Agents -- Economics
KW  - Drug Approval
KW  - Legislation, Drug
KW  - United States Food and Drug Administration
KW  - United States
SP  - 2122
EP  - 2124
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
JA  - AM J HEALTH SYST PHARM AJHP
VL  - 54
IS  - 18
CY  - Bethesda, Maryland
PB  - American Society of Health System Pharmacists
SN  - 1079-2082
AD  - Pharmacy Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
U2  - PMID: 9377212.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105819618&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Alimandi, Maurizio
AU  - Ling-Mei Wang
AU  - Bottaro, Donald
AU  - Chong-Chou Lee
AU  - Angera Kuo
AU  - Frankel, Mark
AU  - Fedi, Paolo
AU  - Tang, Careen
AU  - Lippman, Marc
AU  - Pierce, Jacalyn H.
T1  - Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/09/15/
VL  - 16
IS  - 18
M3  - Article
SP  - 5608
EP  - 5617
SN  - 02614189
AB  - Interleukin-3 (IL-3)-dependent murine 32D cells do not detectably express epidermal growth factor receptors (EGFRs) and do not proliferate in response to EGF, heregulin (HRG) or other known EGF-like ligands. Here, we report that EGF specifically binds to and can be crosslinked to 32D transfectants co-expressing ErbB2 and ErbB3 (32D.E2/E3), but not to transfectants expressing either ErbB2 or ErbB3 individually. [αI]EGF-crosslinked species detected in 32D.E2/E3 cells were displaced by HRG and betacellulin (BTC) but not by other EGF-like ligands that were analyzed. EGF, BTC and HRG also induced receptor tyrosine phosphorylation, activation of downstream signaling molecules and proliferation of 32D.E2/E3 cells. 32D transfectants were also generated which expressed an ErbB3-EGFR chimera alone (32D.E3-E1) or in combination with ErbB2 (32D.E2/E3-E1). While HRG stimulation of 32D.E3-E1 cells resulted in DNA synthesis and receptor phosphorylation, EGF and BTC were inactive. However, EGF and BTC were as effective as HRG in mediating signaling when ErbB2 was co-expressed with the chimera in the 32D.E2/E3-E1 transfectant. These results provide evidence that ErbB2/ErbB3 binding sites for EGF and BTC are formed by a previously undescribed mechanism that requires co-expression of two distinct receptors. Additional data utilizing MDA MB134 human breast carcinoma cells, which naturally express ErbB2 and ErbB3 in the absence of EGFRs, supported the results obtained employing 32D cells and suggest that EGF and BTC may contribute to the progression of carcinomas that co-express ErbB2 and ErbB3. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERLEUKIN-3
KW  - CELLS
KW  - GROWTH factors
KW  - LIGANDS (Biochemistry)
KW  - CELLULAR signal transduction
KW  - CELL receptors
KW  - betacellulin
KW  - epidermal growth factor
KW  - erbb2 receptor
KW  - erbb3 receptor
KW  - signal transduction
N1  - Accession Number: 13005750; Alimandi, Maurizio 1 Ling-Mei Wang 1 Bottaro, Donald 1 Chong-Chou Lee 1 Angera Kuo 1 Frankel, Mark 2 Fedi, Paolo 2 Tang, Careen 3 Lippman, Marc 3 Pierce, Jacalyn H. 1; Affiliation:  1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, 37 Convent Drive, MSC 4255,, Bethesda, MD  2: Mount Sinai School of Medicine, One Gustave L.Levy Place, New York, NY  3: Lombardi Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, Washington, DC, USA; Source Info: 9/15/97, Vol. 16 Issue 18, p5608; Subject Term: INTERLEUKIN-3; Subject Term: CELLS; Subject Term: GROWTH factors; Subject Term: LIGANDS (Biochemistry); Subject Term: CELLULAR signal transduction; Subject Term: CELL receptors; Author-Supplied Keyword: betacellulin; Author-Supplied Keyword: epidermal growth factor; Author-Supplied Keyword: erbb2 receptor; Author-Supplied Keyword: erbb3 receptor; Author-Supplied Keyword: signal transduction; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/16.18.5608
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13005750&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107181537
T1  - The behavior-biology interface in cancer prevention and control science.
AU  - Weed DL
Y1  - 1997/09/15/1997 Sep-Oct
N1  - Accession Number: 107181537. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0322116. 
KW  - Biology
KW  - Health Behavior
KW  - Neoplasms -- Prevention and Control
KW  - Research
KW  - Cancer Screening
KW  - Food Habits
KW  - Quality of Life
KW  - Smoking
SP  - S37
EP  - 41
JO  - Preventive Medicine
JF  - Preventive Medicine
JA  - PREV MED
VL  - 26
IS  - 5 part 2
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
SN  - 0091-7435
AD  - Preventive Oncology Branch, National Cancer Institute, EPS T-41, 9000 Rockville Pike, Bethesda, Maryland 20892
U2  - PMID: 9327491.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107181537&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107346967
T1  - Breast implants and cancer.
AU  - Brinton LA
AU  - Brown SL
Y1  - 1997/09/17/
N1  - Accession Number: 107346967. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Implants
KW  - Breast Neoplasms
KW  - Breast Implants -- Adverse Effects
KW  - Breast Neoplasms -- Etiology
KW  - Breast Neoplasms -- Epidemiology
KW  - Silicones -- Adverse Effects
KW  - Mammography
KW  - Surgery, Reconstructive
KW  - Breast Neoplasms -- Diagnosis
KW  - Epidemiological Research
KW  - Confidence Intervals
KW  - Relative Risk
SP  - 1341
EP  - 1349
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 18
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
U2  - PMID: 9308703.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107247803
T1  - Carrying the burden of cardiovascular risk in old age: associations of weight and weight change with prevalent cardiovascular disease, risk factors, and health status in the Cardiovascular Health Study.
AU  - Harris TB
AU  - Savage PJ
AU  - Tell GS
AU  - Haan M
AU  - Kumanyika S
AU  - Lynch JC
Y1  - 1997/10//
N1  - Accession Number: 107247803. Language: English. Entry Date: 19980301. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: NHLBI contracts NO1-HC-87079, NO1-HC-87080, NO1-HC-87081, NO1-HC-87082, NO1-HC-87083, NO-HC-87084, NO-HC-87085, and NO-HC-87086. NLM UID: 0376027. 
KW  - Weight Gain -- In Old Age
KW  - Weight Loss -- In Old Age
KW  - Cardiovascular Diseases
KW  - Cardiovascular Risk Factors
KW  - Health Status
KW  - Funding Source
KW  - Prospective Studies
KW  - Nonexperimental Studies
KW  - Random Sample
KW  - Pearson's Correlation Coefficient
KW  - Linear Regression
KW  - Multiple Logistic Regression
KW  - Data Analysis Software
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 837
EP  - 844
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 66
IS  - 4
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Measured weight in old age, reported weight at age 50 y, and weight change from age 50 y to old age were studied in association with prevalent cardiovascular disease (CVD), CVD risk factors, and health status in a population of 4954 men and women aged > or = 65 y in the Cardiovascular Health Study (CHS). Heavier weight (i.e., generally weight in the fourth quartile for the cohort) at age 50 y was more closely associated with prevalent CVD than was current weight, with these associations stronger in women than in men. Heavier current weight and heavier weight at age 50 y were associated with cardiovascular risk factors, including higher blood pressure, lower high-density-lipoprotein cholesterol, and higher fasting insulin. Heavier weight at both time points was related to mobility problems in both men and women and to lower current physical activity levels; among women, strong associations were also seen with lower education and current income. Remaining within 10% of reported weight at age 50 y was associated with better health status as measured by reported health, mobility difficulty, number of medications, and prevalent CVD in men. Paradoxically, most cardiovascular risk factors were lowest for weight losers despite an association of weight loss with poorer health. In this cohort of persons aged > or = 65 y, heavier weight was associated with CVD and CVD risk factors, suggesting that prevention of overweight may prove beneficial in improving cardiovascular risk in older persons. Weight stability from age 50 y to old age was associated with better health status than was weight gain or loss. Copyright (c) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Institute on Aging, Epidemiology, Demography and Biometry Program, Gateway Building, Room 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892-9205. E-mail: Tamara_Harris@nih.gov
U2  - PMID: 9322558.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - MORITA, TAKASHI
AU  - HANAOKA, KAZUSHIGE
AU  - MORALES, MARCELO M.
AU  - MONTROSE-RAFIZADEH, CHAHRZAD
AU  - GUGGINO, WILLIAM B.
T1  - Cloning and characterization of maxi K+ channel α-subunit in rabbit kidney.
JO  - American Journal of Physiology: Renal Physiology
JF  - American Journal of Physiology: Renal Physiology
Y1  - 1997/10//
VL  - 42
IS  - 4
M3  - Article
SP  - F615
EP  - F624
SN  - 1931857X
AB  - We have identified in rabbit renal cells two alternatively spliced transcripts of the asubunit rbslo1 and rbslo2. Rbslo1 has a novel ''in-frame'' 174-bp insertion immediately after the predicted S8 transmembrane segment, whereas rbslo2 has a 104-bp deletion between S9 and S10, creating a frameshift and a premature termination codon. Amino acid identity between mouse maxi K+ channel a-subunit (mslo) and rbslo1 was 99%. Two transcript sizes of 4.2 and 7.5 kb were detected in brain, kidney, stomach, testis, and lung. Rbslo is expressed in glomeruli, thin limbs of Henle's loop, medullary and cortical thick ascending limbs of Henle's loop, and cortical, outer, and inner medullary collecting ducts; however, it was rarely detected in proximal convoluted tubules. Rbslo1 is most abundant in inner medulla. Expressed in Xenopus oocytes, rbslo1 generates depolarization-activated, outwardly rectifying K+ currents. Rbslo1 expressed in Chinese hamster ovary cells could be activated by depolarization and Ca2+. These data suggest that rbslo transcripts are expressed in multiple nephron segments and that the magnitude of mRNA expression varies among different nephron segments [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - calcium
KW  - cloning
KW  - potassium channels
KW  - potassium transport
N1  - Accession Number: 96912331; MORITA, TAKASHI 1 HANAOKA, KAZUSHIGE 1 MORALES, MARCELO M. 1 MONTROSE-RAFIZADEH, CHAHRZAD 2 GUGGINO, WILLIAM B. 1; Affiliation:  1: Department of Physiology, Johns Hopkins University School of Medicine  2: National Institute on Aging, Baltimore, Maryland 21205; Source Info: Oct97, Vol. 42 Issue 4, pF615; Author-Supplied Keyword: calcium; Author-Supplied Keyword: cloning; Author-Supplied Keyword: potassium channels; Author-Supplied Keyword: potassium transport; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Erhart, Elizabeth M.
AU  - Coelho Jr., Anthony M.
AU  - Bramblett, Claud A.
T1  - Kin recognition by paternal half-siblings in captive Papio cynocephalus.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1997/10//
VL  - 43
IS  - 2
M3  - Article
SP  - 147
EP  - 157
SN  - 02752565
AB  - Our objective in this study was to evaluate whether a group of paternally related, subadult baboons (Papio cynocephalus ) would preferentially interact with kin or nonkin when they had been raised apart from kin other than their mothers. Subjects and their mothers were removed from the breeding group and placed in alternate housing within 24 h after birth to ensure that the subjects would not have a social history with either their sire or their half-siblings. At 90 days of age, the 23 subjects were separated from their mothers and assigned to a peer–peer social group. Behavioral performance was measured using focal animal sampling techniques and 12 molecular behavioral criteria. Analyses of the data indicate that in dyadic interactions kin did not interact more frequently than nonkin in performance of affiliative, sociosexual, and agonistic behaviors. The hypothesis that baboons recognize kin in the absence of maternal associations was not supported by the data; moreover, we suggest that social learning and social history are the most likely mechanisms for kin recognition. Am. J. Primatol. 43:147–157, 1997. © 1997 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BABOONS
KW  - PRIMATE behavior
KW  - SOCIAL behavior in animals
KW  - ANIMALS
KW  - RESEARCH
KW  - MONKEYS
KW  - kin recognition
KW  - kin selection
KW  - papio
KW  - recognition mechanisms
N1  - Accession Number: 12214630; Erhart, Elizabeth M. 1 Coelho Jr., Anthony M. 2 Bramblett, Claud A. 1; Affiliation:  1: Department of Anthropology, University of Texas, Austin, Texas  2: National Heart, Lung, and Blood Institute, Bethesda, Maryland; Source Info: Oct97, Vol. 43 Issue 2, p147; Subject Term: BABOONS; Subject Term: PRIMATE behavior; Subject Term: SOCIAL behavior in animals; Subject Term: ANIMALS; Subject Term: RESEARCH; Subject Term: MONKEYS; Author-Supplied Keyword: kin recognition; Author-Supplied Keyword: kin selection; Author-Supplied Keyword: papio; Author-Supplied Keyword: recognition mechanisms; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107248502
T1  - The effect of smoking on the serum ionized magnesium concentration is method-dependent.
AU  - Niemela JE
AU  - Cecco SA
AU  - Rehak NN
AU  - Elin RJ
Y1  - 1997/10//1997 Oct
N1  - Accession Number: 107248502. Language: English. Entry Date: 19980301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7607091. 
KW  - Electrodes
KW  - Magnesium -- Analysis
KW  - Smoking
KW  - Laboratory Equipment and Supplies
KW  - Smoking -- Complications
KW  - Hydrogen-Ion Concentration
KW  - In Vitro Studies
KW  - Comparative Studies
KW  - Questionnaires
KW  - Paired T-Tests
KW  - T-Tests
KW  - Linear Regression
KW  - Analysis of Variance
KW  - Reproducibility of Results
KW  - Human
SP  - 1087
EP  - 1092
JO  - Archives of Pathology & Laboratory Medicine
JF  - Archives of Pathology & Laboratory Medicine
JA  - ARCH PATHOL LAB MED
VL  - 121
IS  - 10
CY  - Northfield, Illinois
PB  - College of American Pathologists
SN  - 0003-9985
AD  - Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
U2  - PMID: 9341589.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107243436
T1  - The role of the temporal lobes in recognizing visuospatial materials: remembering versus knowing.
AU  - Blaxton TA
AU  - Theodore WH
Y1  - 1997/10//1997 Oct
N1  - Accession Number: 107243436. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. Instrumentation: Wechsler Adult Intelligence Scale-Revised (WAIS-R). Grant Information: Epilepsy Research Branch of the NINDS. NLM UID: 8218014. 
KW  - Memory
KW  - Visual Perception
KW  - Epilepsy
KW  - Temporal Lobe -- Pathology
KW  - Cognition
KW  - Funding Source
KW  - Experimental Studies
KW  - Data Analysis, Statistical
KW  - Memory -- Evaluation
KW  - Research Instruments
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 5
EP  - 25
JO  - Brain & Cognition
JF  - Brain & Cognition
JA  - BRAIN COGNIT
VL  - 35
IS  - 1
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
SN  - 0278-2626
AD  - National Institute of Neurological Disorders and Stroke, National Institutes of Health
U2  - PMID: 9339299.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107251625
T1  - Management of dry mouth.
AU  - Fox PC
Y1  - 1997/10//1997 Oct
N1  - Accession Number: 107251625. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0217440. 
KW  - Salivary Gland Diseases
KW  - Xerostomia -- Therapy
KW  - Salivary Gland Diseases -- Therapy
KW  - Salivary Gland Diseases -- Complications
KW  - Salivary Gland Diseases -- Physiopathology
KW  - Salivary Gland Diseases -- Etiology
KW  - Saliva
KW  - Drugs, Prescription -- Adverse Effects
SP  - 863
EP  - 875
JO  - Dental Clinics of North America
JF  - Dental Clinics of North America
JA  - DENT CLIN NORTH AM
VL  - 41
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Dry mouth is a common complaint and, when associated with salivary gland dysfunction, a significant problem. Accurate and complete diagnosis of the patient with complaints of xerostomia is essential. Management should be directed to relief of symptoms, control of oral disease, and improvement in salivary function. With a systematic approach and aggressive management, most dry mouth patients can achieve oral comfort and adequate oral function. Copyright (c) 1997 by W.B. Saunders Company
SN  - 0011-8532
AD  - Division of Intramural Research, Clinical Investigations Section, Gene Therapy and Therapeutics Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9344281.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hohjoh, Hirohiko
AU  - Singer, Maxine F.
T1  - Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/10//10/1/97
VL  - 16
IS  - 19
M3  - Article
SP  - 6034
EP  - 6043
SN  - 02614189
AB  - Previous experiments using human teratocarcinoma cells indicated that p40, the protein encoded by the first open reading frame (ORF) of the human LINE-1 (L1Hs) retrotransposon, occurs in a large cytoplasmic ribonucleoprotein complex in direct association with L1Hs RNA(s), the p40 RNP complex. We have now investigated the interaction between partially purified p40 and L1Hs RNA in vitro using an RNA binding assay dependent on co-immunoprecipitation of p40 and bound RNA. These experiments identified two p40 binding sites on the full-length sense strand L1Hs RNA. Both sites are in the second ORF of the 6000 nt RNA: site A between residues 1999 and 2039 and site B between residues 4839 and 4875. The two RNA segments share homologous regions. Experiments involving UV cross-linking followed by immunoprecipitation indicate that p40 in the in vitro complex is directly associated with L1Hs RNA, as it is in the p40 RNP complex found in teratocarcinoma cells. Binding and competition experiments demonstrate that p40 binds to single-stranded RNA containing a p40 binding site, but not to single-stranded or double-stranded DNA, double-stranded RNA or a DNA-RNA hybrid containing a binding site sequence. Thus, p40 appears to be a sequence-specific, single-strand RNA binding protein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RNA
KW  - CARRIER proteins
KW  - BINDING sites (Biochemistry)
KW  - MOBILE genetic elements
KW  - NUCLEOPROTEINS
KW  - TERATOCARCINOMA
KW  - CANCER cells
KW  - MOLECULAR biology
KW  - human high affinity binding site
KW  - line-1 (l1hs)
KW  - non-ltr retrotransposon
KW  - ribonucleoprotein complex
KW  - rna binding protein
N1  - Accession Number: 13005769; Hohjoh, Hirohiko 1 Singer, Maxine F. 1,2; Affiliation:  1: Laboratory of Biochemistry, National Cancer Institute, National Insitute of Health, Bethesda, MD 20892  2: Carnegie Institution of Washington, 1530 P Street NW, Washington, DC 20005, USA; Source Info: 10/1/97, Vol. 16 Issue 19, p6034; Subject Term: RNA; Subject Term: CARRIER proteins; Subject Term: BINDING sites (Biochemistry); Subject Term: MOBILE genetic elements; Subject Term: NUCLEOPROTEINS; Subject Term: TERATOCARCINOMA; Subject Term: CANCER cells; Subject Term: MOLECULAR biology; Author-Supplied Keyword: human high affinity binding site; Author-Supplied Keyword: line-1 (l1hs); Author-Supplied Keyword: non-ltr retrotransposon; Author-Supplied Keyword: ribonucleoprotein complex; Author-Supplied Keyword: rna binding protein; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/16.19.6034
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morgan, Daniel L.
AU  - Mahler, Joel F.
AU  - Wilson, Ralph E.
AU  - Moorman, Michael P.
AU  - Price, Herman C.
AU  - O'Connor, Robert
T1  - Toxicity of Divinylbenzene-55 for B6C3F1 Mice in a Two-Week Inhalation Study.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/10//
VL  - 39
IS  - 2
M3  - Article
SP  - 89
EP  - 100
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Divinylbenzene (DVB) is a crosslinking monomer used primarily for copolymerization with styrene to produce ion-exchange resins. The toxicity of inhaled DVB was investigated because of the potential for worker exposure and the structural similarity of DVB to styrene, a potential carcinogen. Male and female B6C3F1 mice were exposed to 0, 25, 50, or 75 ppm DVB for 6 hr/day, 5 days/week for up to 2 weeks. Six mice/sex/dose group were killed after 3, 5, and 10 exposures and six mice/sex in the 75 ppm group were killed 7 days after 10 exposures. The most severe effects occurred in the nasal cavity and liver, with less severe effects occurring in the kidneys. In the nasal cavity olfactory epithelium acute necrosis and inflammation were present at early time points followed by regeneration, architectural reorganization, and focal respiratory metaplasia by 7 days after the last exposure. Olfactory epithelial changes were concentration-dependent with extensive involvement at 75 ppm and peripheral sparing at 25 ppm. There was also necrosis and regeneration of olfactory-associated Bowman's glands as well as the lateral nasal (Steno's) glands. Hepatocellular centrilobular (CL) necrosis was observed only in the 75 ppm dose group and was similar to that caused by styrene. A time-dependent progression was observed, characterized by CL degeneration after 1 exposure, necrosis after 3 and 5 exposures, and chronic inflammation with CL karyomegaly after 10 exposures and 7 days after the 10th exposure. Hepatic GSH levels were decreased in a dose-dependent manner. In the kidneys, transient tubular damage was observed in some male mice exposed to 75 ppm, and appeared to be a response to DVB-induced tubular epithelial injury. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Metaplasia
KW  - Carcinogenesis
KW  - Mice as laboratory animals
KW  - Crosslinking (Polymerization)
KW  - Copolymerization
KW  - Ion exchange (Chemistry)
N1  - Accession Number: 82423066; Morgan, Daniel L. 1; Mahler, Joel F. 1; Wilson, Ralph E. 1; Moorman, Michael P. 1; Price, Herman C. 2; O'Connor, Robert 2; Affiliations: 1: National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; 2: † Man Tech Environmental Technology, Inc. Research Triangle Park, North Carolina 27709; Issue Info: 1997, Vol. 39 Issue 2, p89; Thesaurus Term: Metaplasia; Thesaurus Term: Carcinogenesis; Subject Term: Mice as laboratory animals; Subject Term: Crosslinking (Polymerization); Subject Term: Copolymerization; Subject Term: Ion exchange (Chemistry); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107164299
T1  - Health communication in the prevention of alcohol, tobacco, and drug use.
AU  - Simons-Morton BG
AU  - Donohew L
AU  - Crump AD
Y1  - 1997/10//
N1  - Accession Number: 107164299. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9704962. 
KW  - Communications Media -- Utilization
KW  - Substance Abuse -- Prevention and Control -- In Adolescence
KW  - Health Promotion
KW  - Alcohol Drinking
KW  - Smoking
KW  - Conceptual Framework
KW  - Social Values
KW  - Adolescence
SP  - 544
EP  - 554
JO  - Health Education & Behavior
JF  - Health Education & Behavior
JA  - HEALTH EDUC BEHAV
VL  - 24
IS  - 5
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
AB  - Research on substance abuse prevention programs indicates that effectiveness is greater when multiple intervention approaches that address the specific vocabulary, perceptions, and values of the target population are employed. The field of health communication provides unique perspectives on media that can be applied to increase the salience and effectiveness of substance abuse prevention programs. Well-designed and well-delivered health communications have the capacity for reaching remote audiences, changing health attitudes and behavior, shaping social norms, changing the way health issues are portrayed by the popular media, and influencing decisions about legislation and policies. Health communication approaches are generally employed within the broad context of health promotion programs, along with education, community development, empowerment, and social change approaches. This article describes the role of health communication in substance abuse prevention, reviews major conceptualizations of health communication, and introduces the unique features of the four articles included in this special section of Health Education & Behavior.
SN  - 1090-1981
AD  - Prevention Research Branch/DESPR, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B05, Bethesda, MD 20852
U2  - PMID: 9307892.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107253063
T1  - Results of a community-based low-literacy nutrition education program.
AU  - Hartman TJ
AU  - McCarthy PR
AU  - Park RJ
AU  - Schuster E
AU  - Kushi LH
Y1  - 1997/10//
N1  - Accession Number: 107253063. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: Adult Basic Learning Examination, Level II. Grant Information: Grant R01-HL-46781 from the National Institutes of Health. NLM UID: 7600747. 
KW  - Community Programs -- Evaluation -- Minnesota
KW  - Nutrition Education
KW  - Literacy
KW  - Minnesota
KW  - Funding Source
KW  - Focus Groups
KW  - Attitude to Health
KW  - Pretest-Posttest Design
KW  - Questionnaires
KW  - Convenience Sample
KW  - Factor Analysis
KW  - Reliability
KW  - Interviews
KW  - Chi Square Test
KW  - Fisher's Exact Test
KW  - T-Tests
KW  - Regression
KW  - Confidence Intervals
KW  - Independent Variable
KW  - Analysis of Covariance
KW  - Diet, Fat-Restricted
KW  - Food Habits
KW  - Government Programs
KW  - Educational Status
KW  - Poverty
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 325
EP  - 341
JO  - Journal of Community Health
JF  - Journal of Community Health
JA  - J COMMUNITY HEALTH
VL  - 22
IS  - 5
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - A nutrition intervention focused on low-fat eating pattern changes was conducted among low-literacy participants in a Twin Cities Metropolitan area Expanded Food and Nutrition Education Program (EFNEP). A total of 134 EFNEP participants who participated in the intervention were compared to 70 comparison participants who received EFNEP nutrition education materials. Associations between changes in outcome variables specific to the intervention were evaluated using mixed-model regression analyses. The principal effects seen for this program were related to changes in eating pattern scales. More modest effects were seen in scales related to attitudes of low-fat eating, and although changes in dietary fat intake as measured by 24-hour dietary interviews suggested a positive intervention effect, this did not approach statistical significance.
SN  - 0094-5145
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 211, 6130 Executive Boulevard MSC 7326, Bethesda, MD 20892-7326
U2  - PMID: 9353681.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Fleischmajer, Raul
AU  - Kühn, Klaus
AU  - Sato, Yoshikazu
AU  - MacDonald II, E. Douglas
AU  - Perlish, Jerome S.
AU  - Pan, Te-Cheng
AU  - Chu, Mon-Li
AU  - Kishiro, Yumiko
AU  - Oohashi, Toshitaka
AU  - Bernier, Suzanne M.
AU  - Yamada, Yoshi
AU  - Ninomiya, Yoshifumi
T1  - There Is Temporal and Spatial Expression of α1 (IV), α2 (IV), α5 (IV), α6 (IV) Collagen Chains and β1 Integrins During the Development of the Basal Lamina in an <em>"In Vitro"</em> Skin Model.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/10//
VL  - 109
IS  - 4
M3  - Article
SP  - 527
EP  - 533
SN  - 0022202X
AB  - Temporal and spatial expression of α1 (IV), α2 (IV), α3 (IV), α4 (IV), α5 (IV), and α6 (IV) collagen chains was studied during the formation of the basal lamina in an "in vitro" skin model. A sequential study was performed at 7-d and 14-d cultures (lamina densa absent) and at 28-, 36-, and 56-d cultures (lamina densa present). Expression of β1, β4, α1, α2, α3, α5, α6 integrin subunits and co-localization with collagen IV was studied by regular and laser confocal indirect immunofluorescence microscopy. mRNA expression of α2 (IV) and α6 (IV) chains was estimated by northern blots. The earliest expression of α1 (IV) and α2 (IV) collagen chains was noted in 7-d cultures restricted to basal keratinocytes. At 14-d cultures, α1 (IV) and α2 (IV) chains were noted in basal keratinocytes and as a broad band (10 μm) in the adjacent dermis. At this stage 80% of the α2 (IV) mRNA was expressed in the dermis and 20% in the epidermis. At 28-, 36-, and 56-d cultures the α1 (IV) and α2 (IV) chains were present in a linear distribution at the epidermo-dermal junction and in the upper dennis. The α6 (LV) collagen chains were expressed much later at 36-d cultures and the α5 (IV) at 56 d, both mostly in a linear distribution but also in the adjacent dermis. α6 (IV) mRNA was demonstrated in the dermis of 36-d cultures. There was co-localization of collagen IV and β1 integrin subunits in 14-.d cultures at the matrix site of keratinocytes. Functional perturbation studies with AIIB2 monoclonal antibody (anti-β1 subunits) and competitive inhibition with a collagen cyanogen bromide digestion derived fragment (CB3 [IV]) that contains the collagen IV ligand for α1β1, α2β1 integrins, altered the pattern of collagen IV deposition. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COLLAGEN
KW  - INTEGRINS
KW  - SKIN
KW  - BASAL lamina
KW  - IMMUNOFLUORESCENCE
KW  - MESSENGER RNA
KW  - <em>collagen IV</em>
N1  - Accession Number: 12336696; Fleischmajer, Raul 1 Kühn, Klaus 2 Sato, Yoshikazu 3 MacDonald II, E. Douglas 1 Perlish, Jerome S. 1 Pan, Te-Cheng 4 Chu, Mon-Li 4 Kishiro, Yumiko 3 Oohashi, Toshitaka 3 Bernier, Suzanne M. 5 Yamada, Yoshi 5 Ninomiya, Yoshifumi 3; Affiliation:  1: Department of Dermatology, Mount Sinai School of Medicine, New York, U.S.A.  2: Max Planck Institute for Biochemistrv, Munich, Germany.  3: Department of Molecular Biology and Biochemistry, University Medical School, Okayama, Japan.  4: Departments of Biochemistry and Molecular Biology, and DermatoIogy, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.  5: Laboratory of Developmental Biology, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct97, Vol. 109 Issue 4, p527; Subject Term: COLLAGEN; Subject Term: INTEGRINS; Subject Term: SKIN; Subject Term: BASAL lamina; Subject Term: IMMUNOFLUORESCENCE; Subject Term: MESSENGER RNA; Author-Supplied Keyword: <em>collagen IV</em>; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/1523-1747.ep12336696
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sanford, Katherine K.
AU  - Parshad, Ram
AU  - Price, Floyd M.
AU  - Tarone, Robert E.
AU  - Thompson, Jean
AU  - Guerry, Dupont
T1  - Radiation-Induced Chromatid Breaks and DNA Repair in Blood Lymphocytes of Patients with Dysplastic Nevi and/or Cutaneous Melanoma.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/10//
VL  - 109
IS  - 4
M3  - Article
SP  - 546
EP  - 549
SN  - 0022202X
AB  - Each chromatid contains a single continuous molecule of double-stranded DNA, so chromatid breaks represent unrepaired DNA double-strand breaks. Frequencies of chromatid breaks after G2 phase x-irradiation were determined in phytohemagglutinin-stimulated blood lymphocytes from normal subjects and from four categories of patients with dysplastic nevi with or without cutaneous melanoma or with melanoma alone. Some cells were treated with an inhibitor of DNA repair replication to determine enzymatic incision activity at damaged sites after exposure to x-rays, UVC, or fluorescent light. Whereas one of 16 normal controls had deficient DNA repair, all 17 patients from families with hereditary dysplastic nevi with or without melanoma (category I) had a deficiency in repair of radiation-induced DNA damage, manifested as an abnormally high frequency of chromatid breaks after x-irradiation or a reduced capacity to incise the damaged sites after UV exposure. Four of 11 patients with sporadic dysplastic nevi alone (category H) and eight of 12 with sporadic dysplastic nevi and melanoma (category III) showed deficient DNA repair after x-irradiation. One of two patients with sporadic melanoma and no dysplastic nevi (category IV) was also deficient in repair of x-ray-induced damage. Deficient DNA repair thus appears to be associated with hereditary dysplastic nevi with or without melanoma. It also characterizes some patients with sporadic dysplastic nevi or melanoma. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN -- Cancer
KW  - DNA repair
KW  - LYMPHOCYTES
KW  - IRRADIATION
KW  - CELLS
KW  - ENZYMES
KW  - <em>deficient DNA repair</em>
N1  - Accession Number: 12336789; Sanford, Katherine K. 1 Parshad, Ram 2 Price, Floyd M. 1 Tarone, Robert E. 3 Thompson, Jean 1 Guerry, Dupont 4; Affiliation:  1: Laboratory of Cellular and Molecular Biology, Bethesda, Maryland, U.S.A.  2: Department of Pathology, Howard University College of Medicine, Washington, DC, U.S.A.  3: Biostatistics National Cancer Institute, Bethesda, Maryland, U.S.A.  4: Pigmented Lesion Group, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, U.S.A.; Source Info: Oct97, Vol. 109 Issue 4, p546; Subject Term: SKIN -- Cancer; Subject Term: DNA repair; Subject Term: LYMPHOCYTES; Subject Term: IRRADIATION; Subject Term: CELLS; Subject Term: ENZYMES; Author-Supplied Keyword: <em>deficient DNA repair</em>; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1523-1747.ep12336789
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hsu, Roger
AU  - Lazarova, Zelmira
AU  - Yee, Carole
AU  - Yancey, Kim B.
T1  - Noncomplement Fixing, IgG4 Autoantibodies Predominate in Patients With Anti-Epiligrin Cicatricial Pemphigoid.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/10//
VL  - 109
IS  - 4
M3  - Article
SP  - 557
EP  - 561
SN  - 0022202X
AB  - This study characterized the specific reactivity, IgG sub-class, and complement fixing ability of anti-laminin-5 IgG from 12 patients with anti-epiligrin cicatricial pemphigoid. Circulating IgG from all patients bound the dermal side of 1 M NaCI split skin, immunoprecipitated laminin-5 produced by biosynthetically radiolabeled human keratinocytes, and (in 10 of 12 cases) immunoblotted the laminin-α3 subunit. Analysis of the distribution of IgG subclasses in these patients' circulating anti-laminin-5 autoantibodies by semiquantitative indirect immunofluorescence microscopy using the HP series of subclass-specific monoclonal antibodies revealed: (i) IgG4 predominant autoantibodies in seven of 11 sera; (ii) IgG1 and IgG2 at substantially lower levels in a smaller number of sera; and (iii) no specific IgG3 anti-laminin-5 autoantibodies in any patients. The same IgG4-dominant profile of anti-laminin-5 autoantibodies was found in enzyme-linked immunosorbent assay studies of purified human laminin 5. Direct immunofluorescence microscopy of six skin biopsies from three patients found that IgG4 was also the predominant subclass of IgG in epidermal basement membranes <em>in situ</em>. Consistent with these findings, sera from 11 of 11 patients with anti-laminin-5 IgG autoantibodies did not fix C3 to epidermal basement membranes <em>in vitro</em>. These immunochemical studies suggest that complement activation does not play a major role in the pathophysiology of this disease and that subepidermal blisters in these patients may develop via a direct effect of anti-laminin-5 IgG itself. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTOANTIBODIES
KW  - SALT
KW  - MICROSCOPY
KW  - ENZYMES
KW  - PATHOLOGICAL physiology
KW  - MONOCLONAL antibodies
KW  - <em>autoimmunity</em>
KW  - <em>bullous disease</em>
KW  - <em>laminin</em>
N1  - Accession Number: 12337073; Hsu, Roger 1 Lazarova, Zelmira 1 Yee, Carole 1 Yancey, Kim B. 1; Affiliation:  1: Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct97, Vol. 109 Issue 4, p557; Subject Term: AUTOANTIBODIES; Subject Term: SALT; Subject Term: MICROSCOPY; Subject Term: ENZYMES; Subject Term: PATHOLOGICAL physiology; Subject Term: MONOCLONAL antibodies; Author-Supplied Keyword: <em>autoimmunity</em>; Author-Supplied Keyword: <em>bullous disease</em>; Author-Supplied Keyword: <em>laminin</em>; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; Number of Pages: 5p; Document Type: Article
L3  - 10.1111/1523-1747.ep12337073
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12337073&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - Weinberg, Wendy C.
AU  - Yuspa, Stuart H.
T1  - An Antibody to p53 Recognizes Soluble Keratins in Epidermal Keratinocyte Cultures Under Differentiating, but not Proliferating, Conditions.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/10//
VL  - 109
IS  - 4
M3  - Letter
SP  - 611
EP  - 612
SN  - 0022202X
AB  - Presents a letter to the editor on an antibody's ability to recognize soluble keratins in epidermal keratinocyte cultures, published in the November 1997 issue of "The Journal of Investigative Dermatology."
KW  - LETTERS to the editor
KW  - IMMUNOGLOBULINS
N1  - Accession Number: 12337539; Weinberg, Wendy C. 1 Yuspa, Stuart H. 1; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892.; Source Info: Oct97, Vol. 109 Issue 4, p611; Subject Term: LETTERS to the editor; Subject Term: IMMUNOGLOBULINS; Number of Pages: 2p; Document Type: Letter
L3  - 10.1111/1523-1747.ep12337539
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107354102
T1  - Research corner. Neuroscience nursing research: challenges for the next decade.
AU  - Leveck MD
Y1  - 1997/10//1997 Oct
N1  - Accession Number: 107354102. Language: English. Entry Date: 19971201. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8603596. 
KW  - Neuroscience Nursing
KW  - Research, Nursing
KW  - National Institute of Nursing Research (U.S.)
KW  - Pain
KW  - Cognition Disorders
KW  - Sleep
SP  - 338
EP  - 341
JO  - Journal of Neuroscience Nursing
JF  - Journal of Neuroscience Nursing
JA  - J NEUROSCI NURS
VL  - 29
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0888-0395
AD  - Scientific Program Administrator, National Institute of Nursing Research, National Institutes of Health, Bldg 45, Room 3AN12, 45 Center Dr, MSC 6300, Bethesda, Maryland 20892-6300
U2  - PMID: 9362004.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107169652
T1  - Outcomes research for rehabilitation: issues and solutions.
AU  - Robertson SC
AU  - Colborn AP
Y1  - 1997/10//1997 Oct
N1  - Accession Number: 107169652. Language: English. Entry Date: 19990301. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 9705774. 
KW  - Outcomes Research
KW  - Rehabilitation
KW  - Case Studies
KW  - Evaluation Research
KW  - Action Research
KW  - Paradigms
SP  - 15
EP  - 23
JO  - Journal of Rehabilitation Outcomes Measurement
JF  - Journal of Rehabilitation Outcomes Measurement
JA  - J REHABIL OUTCOMES MEAS
VL  - 1
IS  - 5
CY  - Frederick, Maryland
PB  - Aspen Law & Business
AB  - The critical need for outcomes research in health care has ignited a search for research designs and methods capable of capturing both the art and effects of rehabilitation practice. Current perceptions of the outcomes construct are presented and methodological limitations for practice are discussed. Included are recommendations: (1) that distinctions be made between program and process outcomes; and (2) that case study, evaluation, and action research be considered as appropriate, mixed-methodological frameworks for capturing the outcomes of diverse rehabilitation practices. Copyright (c) 1997 by Aspen Publishers, Inc.
SN  - 1086-9654
AD  - Associate Investigator and Clinical Research Consultant to the Occupational Therapy Section, Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 
TY  - NEWS
AU  - Solomon, Susan D.
T1  - Obituary: Elizabeth Mary Smith (1939-1997).
JO  - Journal of Traumatic Stress
JF  - Journal of Traumatic Stress
Y1  - 1997/10//
VL  - 10
IS  - 4
M3  - Obituary
SP  - 705
EP  - 707
PB  - John Wiley & Sons, Inc.
SN  - 08949867
AB  - Presents an obituary to Elizabeth Mary Smith, an associate professor of psychiatry, who died on March 7, 1997.
KW  - SMITH, Elizabeth Mary
N1  - Accession Number: 9711204202; Solomon, Susan D. 1; Affiliation:  1: Senior Advisor Office of Behavioral and Social Sciences Research National Institutes of Health Bethesda, MD.; Source Info: Oct97, Vol. 10 Issue 4, p705; People: SMITH, Elizabeth Mary; Number of Pages: 3p; Illustrations: 1 Black and White Photograph; Document Type: Obituary
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Huei-Fung Tsai
AU  - Washburn, Ronald G.
AU  - Chang, Yun C.
AU  - Kwon-Chung, K. J.
T1  - Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997/10//
VL  - 26
IS  - 1
M3  - Article
SP  - 175
EP  - 183
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - <em>Aspergillus fumigatus</em> is an important pathogen causing invasive pulmonary aspergillosis in immunocompromised patients. The fungus propagates by conidia, which are the infectious structures inhaled by the human host. Opsonophagocytosis is thought to contribute to clearance of the inhaled conidia, a process that is facilitated by complement deposition on conidial surfaces. We now show that conidial colour mutants exhibit significant increases in C3 binding capacity compared with wild type. A reddish-pink mutation that led to enhanced C3 binding was complemented by a cosmid clone. A 3.3 kb DNA fragment from the subsequently rescued cosmid was sufficient to restore the bluish-green conidial pigment. The bluish-green transformant exhibited a level of C3 binding similar to that of the parental strain. A gene, designated <em>arp1</em>, was responsible for the complementation. Comparison of the genomic and cDNA sequences of <em>arp1</em> revealed that it has two introns and encodes a putative protein of 168 amino acids. Arp1 is very similar to scytalone dehydratase, an enzyme involved in 1,8-dihydroxynaphthalene-melanin synthesis in <em>Colletotrichum lagenarium</em> and <em>Magnaporthe grisea</em>. Northern hybridization analysis revealed that <em>arp1</em> is developmentally regulated, being expressed during conidiation. Disruption of <em>arp1</em> resulted in reddish-pink conidia and increased C3 binding. Our studies suggest that <em>arp1</em> modulates the bluish-green pigmentation of conidia as well as complement deposition. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Pathogenic microorganisms
KW  - Aspergillus fumigatus
KW  - Aspergillus
KW  - Pulmonary aspergillosis
KW  - Aspergillosis
KW  - Conidia
N1  - Accession Number: 21882148; Huei-Fung Tsai 1; Washburn, Ronald G. 2; Chang, Yun C. 1; Kwon-Chung, K. J. 1; Email Address: jkchung@atlas.niaid.nih.gov; Affiliations: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA; 2: Section on Infectious Diseases, Department of Internal Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC, USA; Issue Info: Oct1997, Vol. 26 Issue 1, p175; Thesaurus Term: Pathogenic microorganisms; Subject Term: Aspergillus fumigatus; Subject Term: Aspergillus; Subject Term: Pulmonary aspergillosis; Subject Term: Aspergillosis; Subject Term: Conidia; Number of Pages: 9p; Illustrations: 1 Color Photograph, 5 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107348992
T1  - Helping a child when a parent has cancer.
AU  - Sparks MJ
Y1  - 1997/10//
N1  - Accession Number: 107348992. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137. 
KW  - Neoplasms -- Psychosocial Factors
KW  - Child -- Psychosocial Factors
KW  - Coping -- In Infancy and Childhood
KW  - Parents
KW  - Parent-Child Relations
KW  - Support, Psychosocial
KW  - Coping -- Education
KW  - Parents -- Education
KW  - Communication
KW  - Patient Education
KW  - Child
SP  - 32hn16
EP  - 7
JO  - Nursing
JF  - Nursing
JA  - NURSING
VL  - 27
IS  - 10
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Teach the family how to prepare her for the road ahead.
SN  - 0360-4039
AD  - Nurse-Manager, National Cancer Institute, Medical Branch at the National Naval Medical Center, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Booth, Victoria
AU  - Carr, Thomas W.
AU  - Erneux, Thomas
T1  - NEAR-THRESHOLD BURSTING IS DELAYED BY A SLOW PASSAGE NEAR A LIMIT POINT.
JO  - SIAM Journal on Applied Mathematics
JF  - SIAM Journal on Applied Mathematics
Y1  - 1997/10//
VL  - 57
IS  - 5
M3  - Article
SP  - 1406
PB  - Society for Industrial & Applied Mathematics
SN  - 00361399
AB  - In a general model for square-wave bursting oscillations, we examine the fast transition between the slowly varying quiescent and active phases. In this type of bursting, the transition occurs at a saddle-node (SN) bifurcation point of the fast-variable subsystem when the slow variable is taken to be the bifurcation parameter. A critical case occurs when the SN bifurcation point is also a steady solution of the full bursting system. In this case near the bursting threshold, the transition suffers a large delay. We propose a first investigation of this critical case that has been noted accidentally but never explored. We present an asymptotic analysis local to the SN point of the fast subsystem and quantitatively describe the slow passage near the SN point underlying the transition delay. Our analysis reveals that bursting solutions showing the longest delays and, correspondingly, the bursting threshold appear near but not exactly at the SN point, as is commonly assumed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of SIAM Journal on Applied Mathematics is the property of Society for Industrial & Applied Mathematics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OSCILLATIONS
KW  - BIFURCATION theory
KW  - SQUARE waves
N1  - Accession Number: 10462088; Booth, Victoria 1,2; Email Address: vbooth@helix.nih.gov Carr, Thomas W. 3,4; Email Address: carr@golem.math.smu.edu Erneux, Thomas 5; Email Address: terneux@ulb.ac.be; Affiliation:  1: Mathematical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health  2: Department of Mathematics, New Jersey Institute of Technology  3: Special Project in Nonlinear Sciences, Code 6700.3, Naval Research Laboratory  4: Department of Mathematics, Southern Methodist University  5: Optique Nonlineaire Theorique, Universite Libre de Bruxelles; Source Info: 1997, Vol. 57 Issue 5, p1406; Subject Term: OSCILLATIONS; Subject Term: BIFURCATION theory; Subject Term: SQUARE waves; Number of Pages: 15p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2004-17486-022
AN  - 2004-17486-022
AU  - Mirsky, Alan F.
T1  - Neuropsychology at the Bedside in the Children's Ward.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1997/10//
VL  - 42
IS  - 10
SP  - 915
EP  - 916
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17486-022. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Mirsky, Alan F.; Section on Clinical and Experimental Neuropsychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Nervous System Disorders; Neural Development; Neuropsychological Assessment; Neuropsychology; Pediatrics. Classification: Neurological Disorders & Brain Damage (3297); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Reviewed Item: Baron, Ida Sue; Fennell, Eileen B.; Voeller, Kytja K. S. Pediatric Neuropsychology in the Medical Setting=New York: Oxford University Press, 1995. 451 pp. $55.00; 1995. Page Count: 2. Issue Publication Date: Oct, 1997. 
AB  - The reviewer explains that the authors' purpose in writing this book (see record [rid]1995-99120-000[/rid]) was to prepare a 'useful practical guide and source book that can support responsible assessment of the medically ill child' (p. viii). The niche the authors have attempted to create for this scholarly work is represented by a major emphasis on the more unusual neurological disorders of childhood, as well as those that are not frequently encountered by neuropsychologists whose practice is primarily with outpatients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurological disorders
KW  - children
KW  - neuropsycholgical assessment
KW  - neurodevelopment
KW  - pediatric neuropsychology
KW  - 1997
KW  - Nervous System Disorders
KW  - Neural Development
KW  - Neuropsychological Assessment
KW  - Neuropsychology
KW  - Pediatrics
KW  - 1997
U2  - Baron, Ida Sue; Fennell, Eileen B.; Voeller, Kytja K. S. (1995); Pediatric Neuropsychology in the Medical Setting; New York: Oxford University Press, 1995. 451 pp. $55.00; 0-19-506345-7.
DO  - 10.1037/000104
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39788-009
AN  - 2015-39788-009
AU  - Fields, R. Douglas
AU  - Eshete, Feleke
AU  - Stevens, Beth
AU  - Itoh, Kouichi
T1  - Action potential-dependent regulation of gene expression: Temporal specificity in Ca2+, cAMP-responsive element binding proteins, and mitogen-activated protein kinase signaling.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/10//
VL  - 17
IS  - 19
SP  - 7252
EP  - 7266
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Fields, R. Douglas, Head, Neurocytology and Physiology Unit, National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Developmental Neurobiology, Building 49, Room 5A38, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-39788-009. PMID: 9295372 Partial author list: First Author & Affiliation: Fields, R. Douglas; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Calcium Ions; Gene Expression; Action Potentials; CREB Activation; Mitogen Activated Protein Kinase. Minor Descriptor: Mice; Phosphorylation. Classification: Electrophysiology (2530). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Oct, 1997. Publication History: Accepted Date: Jul 16, 1997; Revised Date: Jul 14, 1997; First Submitted Date: May 28, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Specific patterns of neural impulses regulate genes controlling nervous system development and plasticity, but it is not known how intracellular signaling cascades and transcriptional activation mechanisms can regulate specific genes in response to specific patterns of action potentials. Studies using electrical stimulation of mouse dorsal root ganglion neurons in culture show that the temporal dynamics of intracellular signaling pathways are an important factor. Expression of c-fos varied inversely with the interval between repeated bursts of action potentials. Transcription was not dependent on a large or sustained increase in intracellular Ca2+, and high Ca2+ levels separated by long interburst intervals (5 min) produced minimal increases in c-fos expression. Levels of the transcription factor cAMP-responsive element binding protein (CREB), phosphorylated at Ser-133, increased rapidly in response to brief action potential stimulation but remained at high levels several minutes after an action potential burst. These kinetics limited the fidelity with which P-CREB could follow different patterns of action potentials, and P-CREB levels were not well correlated with c-fos expression. The extracellular-regulated kinase (ERK) mitogen-activated protein kinases (MAPK) also were stimulated by action potentials of appropriate temporal patterns. Bursts of action potentials separated by long intervals (5 min) did not activate MAPK effectively, but they did increase CREB phosphorylation. This was a consequence of the more rapid dephosphorylation of MAPK in comparison to CREB. High expression of c-fos was dependent on the combined activation of the MAPK pathway and phosphorylation of CREB. These observations show that temporal features of action potentials (and associated Ca2+ transients) regulate expression of neuronal genes by activating specific intracellular signaling pathways with appropriate temporal dynamics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - CREB phosphorylation
KW  - calcium
KW  - c-fos
KW  - signal transduction
KW  - activity-dependent plasticity
KW  - LTP
KW  - MAP kinase
KW  - SRE
KW  - 1997
KW  - Calcium Ions
KW  - Gene Expression
KW  - Action Potentials
KW  - CREB Activation
KW  - Mitogen Activated Protein Kinase
KW  - Mice
KW  - Phosphorylation
KW  - 1997
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39788-034
AN  - 2015-39788-034
AU  - Safieddine, Saaid
AU  - Wenthold, Robert J.
T1  - The glutamate receptor subunit δ1 is highly expressed in hair cells of the auditory and vestibular systems.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/10//
VL  - 17
IS  - 19
SP  - 7523
EP  - 7531
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Safieddine, Saaid, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Laboratory of Neurochemistry, 36 Convent Drive MSC-4162, Building 36, Room 5D08, Bethesda, MD, US, 20892-4162
N1  - Accession Number: 2015-39788-034. PMID: 9295397 Partial author list: First Author & Affiliation: Safieddine, Saaid; Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, US. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Models; Auditory Stimulation; Glutamate Receptors; Vestibular Apparatus; Immunocytochemistry. Minor Descriptor: Dendrites; Gene Expression; Hair. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 1997. Publication History: Accepted Date: Jul 21, 1997; First Submitted Date: Jun 25, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - In the inner ear, fast excitatory synaptic transmission is mediated by ionotropic glutamate receptors, including AMPA, kainate, and NMDA receptors. The recently identified δ1 and δ2 glutamate receptors share low homology with the other three types, and no clear response or ligand binding has been obtained from cells transfected with δ alone or in combination with other ionotropic receptors. Studies of mice lacking expression of δ2 show that this subunit plays a crucial role in plasticity of cerebellar glutamatergic synapses. In addition, these mice show a deficit in vestibular compensation. These findings and the nature of glutamatergic synapses between vestibulocochlear hair cells and primary afferent dendrites suggest that δ receptors may be functionally important in the inner ear and prompted us to investigate the expression of δ receptors in the cochlea and peripheral vestibular system. Reverse transcription and DNA amplification by PCR combined with immunocytochemistry and insitu hybridization were used. Our results show that the expression of δ1 in the organ of Corti is intense and restricted to the inner hair cells, whereas δ1 is expressed in all spiral ganglion neurons as well as in their satellite glial cells. In the vestibular end organ, δ1 was highly expressed in both hair cell types and also was expressed in the vestibular ganglion neurons. The prominent expression of δ1 in inner hair cells and in type I and type II vestibular hair cells suggests a functional role in hair cell neurotransmission. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cochlea
KW  - vestibular end organ
KW  - hair cells
KW  - spiral ganglion neurons
KW  - PCR
KW  - in situ hybridization
KW  - Western blot
KW  - immunocytochemistry
KW  - 1997
KW  - Animal Models
KW  - Auditory Stimulation
KW  - Glutamate Receptors
KW  - Vestibular Apparatus
KW  - Immunocytochemistry
KW  - Dendrites
KW  - Gene Expression
KW  - Hair
KW  - 1997
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107252498
T1  - Consistency between US dietary fat intake and serum total cholesterol concentrations: the National Health and Nutrition Examination Surveys... proceedings of a symposium held at The Rockefeller University, New York, April 24-25, 1995.
AU  - Ernst ND
AU  - Sempos CT
AU  - Briefel RR
AU  - Clark MB
Y1  - 1997/10/02/Oct97 Supplement
N1  - Accession Number: 107252498. Language: English. Entry Date: 19980401. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct97 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Energy Intake
KW  - Dietary Fats -- Administration and Dosage
KW  - Food Habits
KW  - Cholesterol
KW  - Diet Records
KW  - Cholesterol -- Analysis
KW  - Cholesterol, Dietary -- Administration and Dosage
KW  - Lipoproteins -- Analysis
KW  - Surveys
KW  - Cross Sectional Studies
KW  - Descriptive Statistics
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Male
KW  - Human
SP  - 965S
EP  - 72S
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 66
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - The National Health and Nutrition Examination Surveys (NHANESs) are conducted periodically to assess the health and nutritional status of the US population by means of standardized interviews and physical examinations. Since the early 1970s there have been three national cross-sectional surveys: NHANES I, 1971-1974; NHANES II, 1976-1980; and NHANES III, phase 1, 1988-1991. During the 18 y between the midpoint of NHANES I (1972) and the midpoint of phase 1 of NHANES III (1990), the age-adjusted mean percentage of energy from fat declined from 36.4% to 34.1% for adults aged 20-74 y. Trend data are shown for dietary fat and cholesterol as well as for serum cholesterol from NHANES I (1971-1975) to NHANES III (1988-1991) by age, sex, and race-ethnicity. The results document a decline in dietary fat, saturated fat, dietary cholesterol, and serum cholesterol. The observed changes reflect those that are predicted by the classic Keys and Hegsted formulas. Changes in reported intake are matched by similar shifts in the food supply for sources of these nutrients. These changes suggest that the Healthy People 2000 goal of reducing the mean serum cholesterol concentration of US adults to < or = 200 mg/dL (5.17 mmol/L) is attainable. The changes in diet are promising, yet we are challenged to achieve greater reductions in the intake of total fat and saturated fatty acids. Copyright (c) 1997 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Heart, Lung and Blood Institute, II Rockledge Center, 6701 Rockledge Drive, Rockledge Building, Room 8112, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107266740
T1  - Sounding board. Ethical complexities of conducting research in developing countries.
AU  - Varmus H
AU  - Satcher D
Y1  - 1997/10/02/
N1  - Accession Number: 107266740. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Clinical Trials -- Ethical Issues
KW  - Developing Countries
KW  - Research Ethics
KW  - Disease Transmission, Vertical -- Prevention and Control
KW  - Research Subjects -- Ethical Issues
KW  - HIV Infections -- Drug Therapy
KW  - HIV Infections -- Prevention and Control
KW  - Zidovudine -- Therapeutic Use
KW  - Zidovudine -- Economics
KW  - Pregnancy
KW  - Female
SP  - 1003
EP  - 1005
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 337
IS  - 14
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institutes of Health, Bethesda, MD 20892-0148
U2  - PMID: 9309109.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107266740&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Townes, Pia
AU  - Ragan, Paul
T1  - Neurology & Psychiatry.
JO  - Southern Medical Journal
JF  - Southern Medical Journal
Y1  - 1997/10/02/Oct1997 Supplement
VL  - 90
M3  - Article
SP  - S153
EP  - S153
PB  - Lippincott Williams & Wilkins
SN  - 15418243
N1  - Accession Number: 114072363; Townes, Pia 1 Ragan, Paul 1; Affiliation:  1: National Institute of Alcohol Abuse and Alcoholism, NIH, Bethesda, Md.; Source Info: Oct1997 Supplement, Vol. 90, pS153; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107260529
T1  - Diagnosis and treatment of depression in late life. Consensus statement update.
AU  - Lebowitz BD
AU  - Pearson JL
AU  - Schneider LS
AU  - Reynolds CF III
AU  - Alexopoulos GS
AU  - Bruce ML
AU  - Conwell Y
AU  - Katz IR
AU  - Meyers BS
AU  - Morrison MF
AU  - Mossey J
AU  - Niederehe G
AU  - Parmelee P
AU  - Lebowitz, B D
AU  - Pearson, J L
AU  - Schneider, L S
AU  - Reynolds, C F 3rd
AU  - Alexopoulos, G S
AU  - Bruce, M L
AU  - Conwell, Y
Y1  - 1997/10/08/
N1  - Accession Number: 107260529. Language: English. Entry Date: 19980501. Revision Date: 20161112. Publication Type: journal article; review. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Depression -- Therapy -- In Old Age
KW  - Aged
KW  - Aged, 80 and Over
SP  - 1186
EP  - 1190
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 278
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Objective: To reexamine the conclusions of the 1991 National Institutes of Health Consensus Panel on Diagnosis and Treatment of Depression in Late Life in light of current scientific evidence.Participants: Participants included National Institutes of Health staff and experts drawn from the Planning Committee and presenters of the 1991 Consensus Development Conference.Evidence: Participants summarized relevant data from the world scientific literature on the original questions posed for the conference.Process: Participants reviewed the original consensus statement and identified areas for update. The list of issues was circulated to all participants and amended to reflect group agreement. Selected participants prepared first drafts of the consensus update for each issue. All drafts were read by all participants and were amended and edited to reflect group consensus.Conclusions: The review concluded that, although the initial consensus statement still holds, there is important new information in a number of areas. These areas include the onset and course of late-life depression; comorbidity and disability; sex and hormonal issues; newer medications, psychotherapies, and approaches to long-term treatment; impact of depression on health services and health care resource use; late-life depression as a risk factor for suicide; and the importance of the heterogeneous forms of depression. Depression in older people remains a significant public health problem. The burden of unrecognized or inadequately treated depression is substantial. Efficacious treatments are available. Aggressive approaches to recognition, diagnosis, and treatment are warranted to minimize suffering, improve overall functioning and quality of life, and limit inappropriate use of health care resources.
SN  - 0098-7484
AD  - National Institute of Mental Health, Bethesda, Md 20857, USA
U2  - PMID: 9326481.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107259799
T1  - Role of nitric oxide in the vasodilator response to mental stress in normal subjects.
AU  - Cardillo C
AU  - Kilcoyne CM
AU  - Quyyumi AA
AU  - Cannon RO III
AU  - Panza JA
Y1  - 1997/10/15/
N1  - Accession Number: 107259799. Language: English. Entry Date: 19980501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0207277. 
KW  - Hemodynamics -- Physiology
KW  - Nitric Oxide -- Physiology
KW  - Stress, Psychological -- Physiopathology
KW  - Vasodilation -- Physiology
KW  - Blood Pressure -- Drug Effects
KW  - Blood Pressure -- Physiology
KW  - Forearm
KW  - Heart Rate -- Drug Effects
KW  - Heart Rate -- Physiology
KW  - Nitroprusside -- Pharmacodynamics
KW  - Vascular Resistance -- Drug Effects
KW  - Vascular Resistance -- Physiology
KW  - T-Tests
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 1070
EP  - 1074
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
JA  - AM J CARDIOL
VL  - 80
IS  - 8
CY  - Philadelphia, Pennsylvania
PB  - Elsevier Inc.
SN  - 0002-9149
AD  - Cardiology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9352980.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Raeber, Alex J.
AU  - Race, Richard E.
AU  - Brandner, Sebastian
AU  - Priola, Suzette A.
AU  - Sailer, Andreas
AU  - Bessen, Richard A.
AU  - Mucke, Lennart
AU  - Manson, Jean
AU  - Aguzzi, Adriano
AU  - Oldstone, Michael B. A.
AU  - Weissmann, Charles
AU  - Chesebro, Bruce
T1  - Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/10/15/
VL  - 16
IS  - 20
M3  - Product Review
SP  - 6057
EP  - 6065
SN  - 02614189
AB  - Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for agent propagation and pathogenesis are still uncertain. To determine the possible role of astrocytes, we generated mice devoid of murine PrP but expressing hamster PrP transgenes driven by the astrocyte­specific GFAP promoter. After inoculation with hamster scrapie, these mice accumulated infectivity and PrPSc to high levels, developed severe disease after 227 ± 5 days and died 7 ± 4 days later. Therefore, astrocytes could play an important role in scrapie pathogenesis, possibly by an indirect toxic effect on neurons. Interestingly, mice expressing the same transgenes but also endogenous murine PrP genes propagated infectivity without developing disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ASTROCYTES
KW  - TRANSGENIC mice
KW  - GENES
KW  - CHRONIC wasting disease
KW  - PROTEINS
KW  - NEURONS
KW  - astrocytes
KW  - hamster scrapie prions
KW  - prp
KW  - transgenic mice
N1  - Accession Number: 13005820; Raeber, Alex J. 1 Race, Richard E. 2 Brandner, Sebastian 3 Priola, Suzette A. 2 Sailer, Andreas 4 Bessen, Richard A. 2 Mucke, Lennart 5,6 Manson, Jean 7 Aguzzi, Adriano 3 Oldstone, Michael B. A. 5 Weissmann, Charles 1 Chesebro, Bruce 2; Affiliation:  1: Institut für Molekularbiologie, Abteilung I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland  2: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT, USA  3: Institut für Neuropathologie, University Hospital Zürich, Zürich, Switzerland  4: Molecular Neurobiology Laboratory, Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, USA  5: Division of Virology, Department of Neuropharmacology, Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, USA  6: Gladstone Molecular Neurobiology Program, PO Box 419100, San Francisco, CA, USA  7: Institute for Animal Health, AFRC, Edinburgh, UK; Source Info: 10/15/97, Vol. 16 Issue 20, p6057; Subject Term: ASTROCYTES; Subject Term: TRANSGENIC mice; Subject Term: GENES; Subject Term: CHRONIC wasting disease; Subject Term: PROTEINS; Subject Term: NEURONS; Author-Supplied Keyword: astrocytes; Author-Supplied Keyword: hamster scrapie prions; Author-Supplied Keyword: prp; Author-Supplied Keyword: transgenic mice; Number of Pages: 9p; Document Type: Product Review
L3  - 10.1093/emboj/16.20.6057
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weber, Irene T.
AU  - Jin Wu
AU  - Adomat, Jill
AU  - Harrison, Robert W.
AU  - Kimmel, Alan R.
AU  - Wondrak, Ewald M.
AU  - Louis, John M.
T1  - Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/10/15/
VL  - 249
IS  - 2
M3  - Article
SP  - 523
EP  - 530
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Human immunodeficiency virus type 1 (HIV-1) protease hydrolysis of the Gag CA-p2 cleavage site is crucial for virion maturation and is optimal at acidic pH. To understand the processing of the CA-p2 site, we have determined the structure of HIV-1 protease complexed with an analog of the CA-p2 site, the reduced peptide inhibitor Arg-Val-Leu-r-Phe-Glu-Ala-Ahx-NH2 [r denotes the reduced peptide bond and Ahx 2-aminohexanoic acid (norleucine), respectively]. The crystal structure was refined to an Rfactor of 0.17 ,at 0.21-nm resolution. The crystals have nearly the same lattice as related complexes in P212121 which have twofold disordered inhibitor, but are in space group P21, and the asymmetric unit contains two dimers of HIV-1 protease related by 180° rotation. An approximate non-crystallographic symmetry has replaced the exact crystal symmetry resulting in well-ordered inhibitor structure. Each protease dimer binds one ordered inhibitor molecule, but in opposite orientations. The interactions of the inhibitor with the two dimers are very similar for the central P2 Val to P2' Glu residues, but show more wariation for the distal P3 Arg and P4' Ahx residues. Importantly, the carboxylate oxygens of Glu at P2' in the inhibitor are within hydrogen-bonding distance of a carboxylate oxygen of Asp30 of the protease suggesting that the two side chains share a proton. This interaction suggests that the enzyme-substrate complex is additionally stabilized at lower pH. The importance of this interaction is emphasized by the absence of polymorphisms of Asp30 in the protease and variants of P2' Glu in the critical CA-p2 cleavage site. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEOLYTIC enzymes
KW  - HIV (Viruses)
KW  - ACIDITY function
KW  - CRYSTALS
KW  - PROTONS
KW  - VIRAL proteins
KW  - crystal structure
KW  - human immunodeficiency virus protease
KW  - proton-mediated interaction
N1  - Accession Number: 12476875; Weber, Irene T. 1; Email Address: weber@asterix.jci.tju.edu Jin Wu 1 Adomat, Jill 1 Harrison, Robert W. 1 Kimmel, Alan R. 2 Wondrak, Ewald M. 2 Louis, John M. 2; Email Address: jmlouis@helix.nih.gov; Affiliation:  1: Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University  2: Molecular Mechanisms of Development Section, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; Source Info: 10/15/97, Vol. 249 Issue 2, p523; Subject Term: PROTEOLYTIC enzymes; Subject Term: HIV (Viruses); Subject Term: ACIDITY function; Subject Term: CRYSTALS; Subject Term: PROTONS; Subject Term: VIRAL proteins; Author-Supplied Keyword: crystal structure; Author-Supplied Keyword: human immunodeficiency virus protease; Author-Supplied Keyword: proton-mediated interaction; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107271710
T1  - Molecular genetics in clinical practice IX. Breast cancer: the high-risk mutations.
AU  - Brody LC
AU  - Biesecker BB
Y1  - 1997/10/15/
N1  - Accession Number: 107271710. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Breast Neoplasms -- Familial and Genetic
KW  - Genes
KW  - Mutation
KW  - Education, Continuing (Credit)
KW  - Breast Neoplasms -- Ethnology
KW  - Breast Neoplasms -- Epidemiology
KW  - Genetics, Medical
KW  - Disease Susceptibility -- Familial and Genetic
KW  - Family History
KW  - Genetic Screening
KW  - Risk Factors
KW  - Risk Assessment
KW  - Jews
KW  - Female
SP  - 59
EP  - 72
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 32
IS  - 10
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - National Human Genome Research Institute, Bethesda, MD
U2  - PMID: 9341636.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271710&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Ying-Kai Wang
AU  - Lee, Joon H.
AU  - Brewer, John M.
AU  - Hoover, Timothy R.
T1  - A conserved region in the σ54-dependent activator DctD is involved in both binding to RNA polymerase and coupling ATP hydrolysis to activation.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1997/10/15/
VL  - 26
IS  - 2
M3  - Article
SP  - 373
EP  - 386
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - <em>Rhizobium melioti</em> DctD activates transcription from the <em>dctA</em> promoter by catalysing the isomerization of closed complexes between σ54-RNA polymerase holoenzyme and the promoter to open complexes. DctD must make productive contact with σ54-holoenzyme and hydrolyse ATP to catalyse this isomerization. To define further the activation process, we sought to isolate mutants of DctD that had reduced affinities for σ54-holoenzyme. Mutagenesis was confined to the well-conserved C3 region of the protein, which is required for coupling ATP hydrolysis to open complex formation in σ54-dependent activators. Mutant forms of DctD that failed to activate transcription and had substitutions in the C-terminal half of the C3 region were efficiently cross-linked to σ54 and the β-subunit of RNA polymerase, suggesting that they bound normally to σ54-holoenzyme. In contrast, some mutant forms of DctD with amino acid substitutions in the N-terminal half of the C3 region had reduced affinities for σ54 and the β-subunit in the cross-linking assay. These data suggest that the N-terminal half of the C3 region of DctD contains a site that may contact σ54-holoenzyme during open complex formation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Adenosine triphosphate
KW  - Mutation (Biology)
KW  - Rhizobium meliloti
KW  - Promoters (Genetics)
KW  - Genetic transcription
KW  - Mutagenesis
N1  - Accession Number: 21343338; Ying-Kai Wang 1; Lee, Joon H. 1,2; Brewer, John M. 3; Hoover, Timothy R. 1; Email Address: hoover@bscr.uga.edu; Affiliations: 1: Department of Microbiology, University of Georgia, Athens, GA 30602, USA; 2: Molecular Genetics of Lower Eukaryotes Section, NICHD/National Institutes of Health, Bethesda, MD 20892, USA; 3: Department of Biochemistry, University of Georgia, Athens, GA 30602, USA; Issue Info: Oct1997, Vol. 26 Issue 2, p373; Thesaurus Term: Adenosine triphosphate; Thesaurus Term: Mutation (Biology); Subject Term: Rhizobium meliloti; Subject Term: Promoters (Genetics); Subject Term: Genetic transcription; Subject Term: Mutagenesis; Number of Pages: 14p; Illustrations: 6 Diagrams, 4 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kosten, Thomas R.
AU  - Rosen, Marc I.
AU  - Mcmahon, Thomas L.
AU  - Bridge, P T. Peter
AU  - O'maiiey, Stephanie S.
AU  - Pearsall, Rowland
AU  - O'connor, Patrick G.
T1  - Treatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T.
JO  - American Journal of Drug & Alcohol Abuse
JF  - American Journal of Drug & Alcohol Abuse
Y1  - 1997/11//
VL  - 23
IS  - 4
M3  - Article
SP  - 543
EP  - 553
SN  - 00952990
AB  - This placebo-controlled, double blind, cross-over study tested the efficacy of two different doses of Peptide T in the treatment of nine intravenous drug users with early AIDS dementia who were also receiving methadone and AZT. Subjects received Peptide T doses of either 15 or 1.5 mg daily for four weeks. Neuropsychological performance improved in four of five patients treated with the high dose, but at the lower dose, three of four patients showed no improvement on Peptide T when compared with placebo. When subjects who received the high dose were compared with those who received the low dose, a significant dose effect was found only during the active phase of the trial even after correction for differences in level of functioning at baseline. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS dementia complex
KW  - AIDS (Disease) -- Complications
KW  - DEMENTIA
KW  - INTRAVENOUS drug abusers
KW  - AZT (Drug)
KW  - ANTIVIRAL agents
N1  - Accession Number: 9712014601; Kosten, Thomas R. 1 Rosen, Marc I. 1 Mcmahon, Thomas L. 1 Bridge, P T. Peter 1 O'maiiey, Stephanie S. 2 Pearsall, Rowland 2 O'connor, Patrick G. 3; Affiliation:  1: Division of Substance Abuse, Department of Psychiatry, West Haven, Connecticut.  2: Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.  3: National Institute on Drug Abuse, Medications Development Division, Rockville, Maryland.; Source Info: 1997, Vol. 23 Issue 4, p543; Subject Term: AIDS dementia complex; Subject Term: AIDS (Disease) -- Complications; Subject Term: DEMENTIA; Subject Term: INTRAVENOUS drug abusers; Subject Term: AZT (Drug); Subject Term: ANTIVIRAL agents; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MANDON, BÉATRICE
AU  - NIELSEN, SØREN
AU  - KISHORE, BELLAMKONDA K.
AU  - KNEPPER, MARK A.
T1  - Expression of syntaxins in rat kidney.
JO  - American Journal of Physiology: Renal Physiology
JF  - American Journal of Physiology: Renal Physiology
Y1  - 1997/11//
VL  - 42
IS  - 5
M3  - Article
SP  - F718
EP  - F730
SN  - 1931857X
AB  - Previously, we demonstrated that a putative vesicle-targeting protein, syntaxin-4, is expressed in renal collecting duct principal cells and is localized to the apical plasma membrane, suggesting a role in targeting aquaporin- 2-containing vesicles to the apical plasma membrane. To investigate whether other syntaxin isoforms are present in the renal collecting duct, we determined the intrarenal localization of syntaxin-2 and -3. Reverse transcriptionpolymerase chain reaction (RT-PCR) experiments using total RNA extracted from kidney and various organs revealed that both syntaxin-2 and -3 are expressed in kidney cortex and medulla. RT-PCR experiments using microdissected tubules and vascular structures from the kidney revealed that syntaxin- 3 mRNA, but not syntaxin-2, is expressed in collecting duct cells. Syntaxin-3 mRNA was also relatively abundant in the thick ascending limb of Henle's loop and in vasa recta. Syntaxin-2 mRNA was found chiefly in glomeruli. To investigate the localization of syntaxin-3 protein, a peptide-derived polyclonal antibody was raised in rabbits. In immunoblotting experiments, this antibody labeled a 37-kDa protein in inner medulla that was most abundant in plasma membraneenriched subcellular fractions. Immunoperoxidase labeling of thin cryosections combined with immunogold electron microscopy showed that, in contrast to the labeling seen for syntaxin- 4, syntaxin-3 labeling in medullary collecting duct was predominantly in the basolateral plasma membrane of intercalated cells. These results suggest the possibility that syntaxin- 3 may be involved in selective targeting of acid-base transporters and/or in basolateral membrane remodeling in response to systemic acid-base perturbations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - aquaporin
KW  - collecting duct
KW  - vasopressin
KW  - vesicle-targeting receptors
KW  - water channel
N1  - Accession Number: 96912343; MANDON, BÉATRICE 1 NIELSEN, SØREN 2 KISHORE, BELLAMKONDA K. 1 KNEPPER, MARK A. 1; Affiliation:  1: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-0951  2: Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark; Source Info: Nov97, Vol. 42 Issue 5, pF718; Author-Supplied Keyword: aquaporin; Author-Supplied Keyword: collecting duct; Author-Supplied Keyword: vasopressin; Author-Supplied Keyword: vesicle-targeting receptors; Author-Supplied Keyword: water channel; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105819775
T1  - Risk factors and early detection of lung cancer in a cohort of Chinese tin miners.
AU  - Qiao YL
AU  - Taylor PR
AU  - Yao SX
AU  - Erozan YS
AU  - Luo XC
AU  - Barrett MJ
AU  - Yan QY
AU  - Giffen CA
AU  - Huang SQ
AU  - Maher MM
AU  - Forman MR
AU  - Tockman MS
Y1  - 1997/11//1997 Nov
N1  - Accession Number: 105819775. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Lung Neoplasms -- Epidemiology
KW  - Metals
KW  - Mining
KW  - Occupational Diseases -- Epidemiology
KW  - Adult
KW  - Aged
KW  - Arsenic -- Adverse Effects
KW  - China
KW  - Female
KW  - Incidence
KW  - Lung Neoplasms -- Diagnosis
KW  - Lung Neoplasms -- Etiology
KW  - Male
KW  - Middle Age
KW  - Occupational Diseases -- Diagnosis
KW  - Occupational Diseases -- Etiology
KW  - Prospective Studies
KW  - Questionnaires
KW  - Radon -- Adverse Effects
KW  - Risk Factors
KW  - Smoking
KW  - Human
SP  - 533
EP  - 541
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 7
IS  - 8
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: To examine risk factors and establish a biologic specimen and data bank for the study of early markers of lung cancer. METHODS: We designed a dynamic cohort using an ongoing lung cancer screening program among radon- and arsenic-exposed tin miners in Yunnan China. Through the first four years of the study, 8,346 miners aged 40 years and older with over 10 years of occupational exposure have been enrolled, risk factors have been assessed, annual sputum and chest radiographs have been obtained, and numerous biologic specimens have been collected. RESULTS: A total of 243 new lung cancer cases have been identified through 1995. Radon and arsenic exposures are the predominant risk factors, but lung cancer risk is also associated with chronic bronchitis and silicosis, as well as a number of exposure to tobacco smoke, including early age of first use, duration, and cumulative exposure. Tumor and sputum samples are being examined for early markers of lung cancer. CONCLUSION: A cohort of occupationally-exposed tin miners with an extensive biologic specimen repository has been successfully established to simultaneously study the etiology and early detection of lung cancer.
SN  - 1047-2797
AD  - Cancer Prevention Studies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7326, USA.
U2  - PMID: 9408549.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sternberg, Kathleen J.
AU  - Lamb, Michael E.
AU  - Hershkowitz, Irit
AU  - Yudilevitch, Liora
AU  - Orbach, Yale
AU  - Esplin, Philip W.
AU  - Hovav, Meir
T1  - EFFECTS OF INTRODUCTORY STYLE ON CHILDREN'S ABILITIES TO DESCRIBE EXPERIENCES OF SEXUAL ABUSE.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1997/11//
VL  - 21
IS  - 11
M3  - Article
SP  - 1133
EP  - 1146
SN  - 01452134
AB  - Objective: The goal of this study was to evaluate the relative effectiveness of two rapport-building techniques for eliciting information from children who made allegations of sexual abuse. Method: Fourteen interviewers conducted 51 investigations of child sexual abuse with children ranging from 4.5 to 12.9 years of age. In 25 of the investigations, interviewers used a script including many open-ended utterances to establish rapport, whereas in 26 of the investigations the same interviewers used a rapport-building script involving many direct questions. Both rapport-building scripts took about 7 minutes to complete. All children were asked the same open-ended question to initiate the substantive phase of the interview. Results: Children who had been trained in the open-ended condition provided 2 1/2 times as many details and words in response to the first substantive utterance as did children in the direct introduction condition. Children in the open-ended condition continued to respond more informatively to open-ended utterances in the later (unscripted) portion of the interview. Two-thirds of the children mentioned the core details of the incident in their responses to the first substantive utterance and a further 20% mentioned core details more vaguely. Conclusions: These results demonstrate that children respond more informatively to an open-ended invitation when they have previously been trained to answer such questions rather than more focused questions. These results demonstrate the sensitivity of children to the goals and expectations of forensic interviewers. Structured interview protocols also increase the amount of information provided by young interviewees. (English) [ABSTRACT FROM AUTHOR]
AB  - Objetivo: La meta de este estudio era evaluar la efectividad relativa de dos técnicas para el establecimiento de un "rapport" que permita obtener información en niños que han realizado alegaciones de abuso sexual. Método: Catorce entrevistadores realizaron 51 investigaciones de abuso sexual infantil con niños que tenían entre 4.5 y 12.9 años de edad. En 25 de las investigaciones, los entrevistadores utilizaron un guión que incluyó muchas expresiones abiertas para establecer el "rapport", mientras que en 26 de las investigaciones, los mismos entrevistadores utilizaron un guión para 'establecer el "rapport" que incluía muchas preguntas directas. Ambos guiones precisaban 7 minutos para ser completados. Todos los niños fueron preguntados con las mismas preguntas de final abierto para iniciar la fase sustantiva de la entrevista. Resultados: Los niños que habían sido entrenados en la condición "de preguntas abiertas" proporcionaron dos veces y media más detalles y palabras en respuesta a la primera pregunta sustantiva que los niños de la condición de introducción directa a la entrevista. Los niños de la condición "de preguntas abiertas" continuaron respondiendo de manera más informativa a las preguntas abiertas en la última parte de la entrevista (que no tenía ningún guión). dos tercios de los niños mencionaron los detalles centrales del incidente en sus respuestas a la primera pregunta sustantiva y más de un 20% mencionaron detalles centrales de manera más imprecisa. Conclusiones: Estos resultados demuestran que los niños responden de manera más informativa a una pregunta abierta, cuando han sido premiamente entrenados a responder a tales cuestiones que cuando han sido entrenados a responder a cuestiones más localizadas. Estos resultados... (Spanish) [ABSTRACT FROM AUTHOR]
AB  - But: Le but de cette étude a été d'évaluer l'efficacité relative de deux techniques de construction d'un rapport pour susciter des informations d'enfants ayant signalé une abus sexuel. Méthodes: Quatorze interrogateurs ont mené 51 enquêtes d'abus sexuel concernant des enfants âgés de 4.5 à 12.9 ans. Dans 25 enquêtes, les interrogateurs utilisaient un script aux questions ouvertes pour établir un rapport tandis que dans 26 enquêtes les mêmes interogateurs utilisaient un script aux questions directes. Les deux interrogatoires ont pris 7 minutes. Tous les enfants ont eu les mêmes questions ouvertes pour initier la phase substantielle de l'interrogatoire. Résultats: Les enfants qui ont été entraîné de manière ouverte fournissaient 2.5 fois plus de détails et de mots en réponse au premier interrogatoire substantiel que les enfants ayant eu une introduction directe. Les enfants formés aux questions ouvertes continuaient à répondre de manière plus informative aux questions ouvertes de la partie plus tardive (non scénarisée) de l'interview. Deux tiers des enfants ont mentionné les détails substantiels de l'incident dans leur réponse au premier interrogatoire substantiel et un autre 20% ont mentionné des détails substantiels de manière plus vague. Conclusions: Les résultats démontrent que les enfants fournissent des informations plus pertinentes à des questions ouvertes lorsqu'ils ont été formés préalablement à répondre à des questions de ce type plutôt qu'à des questions dirigées. Les résultats démontrent la sensibilité des enfants aux buts et aux attentes des interrogatoires structurés et ceux-ci... (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD sexual abuse
KW  - CHILD psychology
KW  - CHILD abuse
KW  - INTERVIEWING in child abuse
KW  - SEX crimes
KW  - Disclosure
KW  - Forensic interviews
KW  - Open-ended invitations
KW  - Sexual abuse
N1  - Accession Number: 9711175011; Sternberg, Kathleen J. 1 Lamb, Michael E. 1 Hershkowitz, Irit 1 Yudilevitch, Liora 1 Orbach, Yale 1 Esplin, Philip W. 2 Hovav, Meir 3; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, MD, USA  2: University of Haifa, Haifa, Israel  3: Forensic Psychologist, Phoenix, AZ, USA; Source Info: Nov97, Vol. 21 Issue 11, p1133; Subject Term: CHILD sexual abuse; Subject Term: CHILD psychology; Subject Term: CHILD abuse; Subject Term: INTERVIEWING in child abuse; Subject Term: SEX crimes; Author-Supplied Keyword: Disclosure; Author-Supplied Keyword: Forensic interviews; Author-Supplied Keyword: Open-ended invitations; Author-Supplied Keyword: Sexual abuse; Number of Pages: 14p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Longnecker, Matthew P.
AU  - Sandler, Dale P.
AU  - Haile, Robert W.
AU  - Sandler, Robert S.
T1  - Phenolphthalein-containing Laxative Use in Relation to Adenomatous Colorectal Polyps in Three Studies.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1997/11//
VL  - 105
IS  - 11
M3  - Article
SP  - 1
EP  - 1
SN  - 00916765
AB  - Focuses on phenolphthalein, the active ingredient in many laxatives, that was recently found to be a carcinogen in animal models. Examination of the use of phenolphthalein-containing laxatives in relation to occurrence of adenomatous colorectal polyps in three studies.
KW  - Carcinogens
KW  - Animal models in research
KW  - Phenolphthalein
KW  - Laxatives
KW  - Polyps (Pathology)
KW  - Colon cancer
N1  - Accession Number: 13013378; Longnecker, Matthew P. 1; Sandler, Dale P. 1; Haile, Robert W. 2; Sandler, Robert S. 3; Affiliations: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA.; 2: University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033 USA.; 3: Division of Digestive Diseases and Nutrition, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA.; Issue Info: Nov1997, Vol. 105 Issue 11, p1; Thesaurus Term: Carcinogens; Thesaurus Term: Animal models in research; Subject Term: Phenolphthalein; Subject Term: Laxatives; Subject Term: Polyps (Pathology); Subject Term: Colon cancer; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 1p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107235380
T1  - Special feature. The history and development of the EAPC: part II... European Association for Palliative Care.
AU  - Blumhuber H
AU  - De Conno F
AU  - Vanegas G
Y1  - 1997/11//1997 Nov-Dec
N1  - Accession Number: 107235380. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; directories; tables/charts. Journal Subset: Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9434451. 
KW  - Palliative Care -- Organizations
KW  - Organizational Objectives
KW  - Membership
KW  - Organizational Structure
KW  - Information Resources
SP  - 210
EP  - 215
JO  - European Journal of Palliative Care
JF  - European Journal of Palliative Care
JA  - EUR J PALLIAT CARE
VL  - 4
IS  - 6
PB  - Hayward Medical Communications
AB  - In the concluding part of this article, Heidi Blumhuber, Franco De Conno and Guillermo Vanegas explain the structure, development and activities of the EAPC.
SN  - 1352-2779
AD  - National Cancer Institute, Milan, Italy
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Miller, Mark Steven
AU  - McCarver, Deborah Gail
AU  - Bell, Douglas A.
AU  - Eaton, David L.
AU  - Goldstein, Joyce A.
T1  - Genetic Polymorphisms in Human Drug Metabolic Enzymes1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/11//
VL  - 40
IS  - 1
M3  - Article
SP  - 1
EP  - 14
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Results obtained from both epidemiologic studies and experimental animal model systems have shown a wide range of phenotypic variation in the ability of individuals to metabolize drugs and environmental chemicals. Several studies have noted correlations between specific metabolic phenotypes and the incidence of disease, suggesting that certain allelic forms of drug metabolic enzymes can render the individual either more sensitive or resistant to the toxic or therapeutic effects of exogenous drugs and chemicals. While some of this variation can be attributed to different environmental exposures, it has become clear that genetic factors also play an important role in determining the response of the individual organism to exogenous agents. Recent advances in molecular biological techniques have begun to allow scientists to correlate observed phenotypic differences with the actual differences in genetic sequence at the gene level. This has allowed a correlation between gene structure and function, thus providing a mechanistic basis to explain the interaction between genetic background and individual response to environmental exposures. Results presented at this symposium discussed how genetic polymorphisms for both Phase I and Phase II metabolic enzymes in the human population modulate the response to environmental toxicants.. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 82502622; Miller, Mark Steven 1; McCarver, Deborah Gail 2; Bell, Douglas A. 3; Eaton, David L. 4; Goldstein, Joyce A. 5; Affiliations: 1: Department of Cancer Biology, Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University Winston-Salem, North Carolina 27157; 2: † Department of Pediatrics and Pharmacology, Children's Hospital of Michigan, Wayne State University Detroit, Michigan 48201; 3: ‡ Laboratory of Biochemical Risk Analysis P.O. Box 12233, Research Triangle Park North Carolina 27709; 4: § Center for Ecogenetics and Environmental Health, Department of Environmental Health, University of Washington Seattle, Washington 98105-6099; 5: ¶ Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park North Carolina 27709; Issue Info: 1997, Vol. 40 Issue 1, p1; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Richard, Gabriela
AU  - Lin, Jing-Ping
AU  - Smith, Lisa
AU  - Whyte, Yolanda M.
AU  - Itin, Peter
AU  - Wollina, Uwe
AU  - Epstein Jr, Ervin
AU  - Hohl, Daniel
AU  - Giroux, Jean-Mario
AU  - Charnas, Lawrence
AU  - Bale, Sherri J.
AU  - DiGiovanna, John J.
T1  - Linkage Studies in Erythrokeratodermias: Fine Mapping, Genetic Heterogeneity, and Analysis of Candidate Genes.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/11//
VL  - 109
IS  - 5
M3  - Article
SP  - 666
EP  - 671
SN  - 0022202X
AB  - Erythrokeratodermias are a clinically heterogeneous group of rare autosomal dominant disorders of cornification with overlapping features including hyperkeratosis and erythema. We ascertained five extended pedigrees with different phenotypes for a linkage study. Three families presented with localized erythrokeratodermia variabilis, and one with erythrokeratodermia and ataxia. Another family had Greither disease associated with variable hyperkeratotic plaques. Despite their phenotypic differences, both erythrokeratodermia variabilis and erythrokeratodermia with ataxia map to a common region in 1p34-p35. Multipoint linkage and haplotype analyses place erythrokeratodermia variabilis between the marker D1S496 and D1S186 with a maximum LOD score of 12.88. Our linkage results provide compelling evidence for genetic homogeneity among families of mixed European and French--Canadian origin. In contrast, results excluded Greither's disease from the established erythrokeratodermia variabilis gene region indicating genetic heterogeneity of erythrokeratodermias. Based on recombinations, two genes assigned to 1p34-p35 were excluded: cartilage matrix protein and avian myelocytosis viral oncogene. Connexin-37 (<em>GJA4</em>), a member of the connexin gene family, maps within the erythrokeratodermia variabilis region and is an attractive candidate gene. Direct sequencing of the coding region of <em>GJA4</em> in four patients revealed several variations, including a novel polymorphism within the 5′ cytoplasmic domain, but no pathogenic mutations were found, thus excluding Connexin-37 as a candidate. There is evidence, however, that other epidermally expressed connexins cluster in this region, and one may yet be determined to play a role in the pathogenesis of erythrokeratodermia variabilis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENES
KW  - KERATOSIS
KW  - ERYTHEMA
KW  - PHENOTYPE
KW  - HOMOGENEITY
KW  - EXTRACELLULAR matrix proteins
KW  - <em>ataxia</em>
KW  - <em>chromosome 1</em>
KW  - <em>connexin</em>
KW  - <em>erythrokeratodermia variabilis</em>
KW  - <em>greither disease</em>
N1  - Accession Number: 12337713; Richard, Gabriela 1 Lin, Jing-Ping 1 Smith, Lisa 1 Whyte, Yolanda M. 1 Itin, Peter 2 Wollina, Uwe 3 Epstein Jr, Ervin 4 Hohl, Daniel 5 Giroux, Jean-Mario 6 Charnas, Lawrence 7 Bale, Sherri J. 1 DiGiovanna, John J. 8,9; Affiliation:  1: Genetic Studies Section, Laboratory of Skin Biology, National Institutes of Health, Bethesda, Maryland, U.S.A.  2: Department of Dermatology, University Basel, Bawl, Switzerland.  3: Department of Dermatology, University Jena, Jena, Germany.  4: Department of Dermatology, San Francisco General Hospital, University of California, San Francisco, California, U.S.A.  5: Department of Dermatology, Hospital Beaumont Lausanne, Switzerland.  6: Department of Medicine, Section of Dermatology, Hotel-Dieu Hospital and University of Montréal, Canada.  7: Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, U.S.A.  8: Dermatology Clinical Research Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.  9: Dermatopharmacology Division, Department of Dermatology, Brown University School of Medicine, Providence, Rhode Island.; Source Info: Nov97, Vol. 109 Issue 5, p666; Subject Term: GENES; Subject Term: KERATOSIS; Subject Term: ERYTHEMA; Subject Term: PHENOTYPE; Subject Term: HOMOGENEITY; Subject Term: EXTRACELLULAR matrix proteins; Author-Supplied Keyword: <em>ataxia</em>; Author-Supplied Keyword: <em>chromosome 1</em>; Author-Supplied Keyword: <em>connexin</em>; Author-Supplied Keyword: <em>erythrokeratodermia variabilis</em>; Author-Supplied Keyword: <em>greither disease</em>; Number of Pages: 6p; Document Type: Article
L3  - 10.1111/1523-1747.ep12337713
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yang, Jun-Mo
AU  - Yoneda, Kozo
AU  - Morita, Eishin
AU  - Imamura, Sadao
AU  - Nam, Kiebang
AU  - Lee, Eil-Soo
AU  - Steinert, Peter M.
T1  - An Alanine to Proline Mutation in the 1A Rod Domain of the Keratin 10 Chain in Epidermolytic Hyperkeratosis.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1997/11//
VL  - 109
IS  - 5
M3  - Article
SP  - 692
EP  - 694
SN  - 0022202X
AB  - We report a mutation in a case of epidermolytic hyperkeratosis that results in a proline for alanine substitution in the residue position 12 of the 1A subdomain of the keratin 10 chain (codon 158). The disease phenotype is consistent with the inappropriate substitution of a proline near the beginning of the rod domain, because it is likely to seriously disrupt the structural organization of coiled-coil molecules within keratin intermediate filaments. Mutations/substitutions in this position have not been reported in any keratin disease. Position 12 is an alanine in all intermediate filament chains, and lies in the outer b heptad position of the coiled-coil. In vitro peptide interference assembly assays revealed that substitutions that alter residue size or charge at this position primarily interfere with keratin filament elongation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALANINE
KW  - MUTATION (Biology)
KW  - KERATIN
KW  - KERATOSIS
KW  - PROLINE
KW  - PHENOTYPE
KW  - keratin intermediate filament structure
KW  - type I keratin
N1  - Accession Number: 12338320; Yang, Jun-Mo 1,2 Yoneda, Kozo 3 Morita, Eishin 4 Imamura, Sadao 3 Nam, Kiebang 2 Lee, Eil-Soo 1 Steinert, Peter M. 5; Affiliation:  1: Department of Dermatology, College of Medicine, Sung Kyun Kwan University, Seoul, Korea.  2: Clinical and Basic Research Centre, Samsung Biomedical Research Institute, Seoul, Korea.  3: Department of Dermatology, College of Medicine, Kyoto University, Kyoto, Japan.  4: Department of Dermatology, College of Medicine, Hiroshima University, Kyoto and Hiroshima, Japan.  5: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov97, Vol. 109 Issue 5, p692; Subject Term: ALANINE; Subject Term: MUTATION (Biology); Subject Term: KERATIN; Subject Term: KERATOSIS; Subject Term: PROLINE; Subject Term: PHENOTYPE; Author-Supplied Keyword: keratin intermediate filament structure; Author-Supplied Keyword: type I keratin; Number of Pages: 3p; Document Type: Article
L3  - 10.1111/1523-1747.ep12338320
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zahm, Shelia Hoar
T1  - Mortality Study of Pesticide Applicators and Other Employees of a Lawn Care Service Company.
JO  - Journal of Occupational Medicine
JF  - Journal of Occupational Medicine
Y1  - 1997/11//
M3  - Article
SP  - 1055
EP  - 1067
SN  - 00961736
AB  - In response to reports linking non-Hodgkin's lymphoma (NHL) and the herbicide 2,4-dichlorophenoxyacetic acid, a retrospective cohort mortality study of 32,600 employees of a lawn care company was conducted. The cohort was generally young with short-duration employment and follow-up. In comparison to the US population, the cohort had significantly decreased mortality from all causes of death combined (307 deaths), arteriosclerotic heart disease, and accidents. There were 45 cancer deaths (59.6 expected, standardized mortality ratio [SMR] = 0.76, 95% confidence interval [CI] = 0.55, 1.01). Bladder cancer mortality was significantly increased, but two of the three observed deaths had no direct occupational contact with pesticides. There were four deaths due to NHL (SMR = 1.14, CI = 0.31, 2.91); three were male lawn applicators (SMR = 1.63, CI = 0.33, 4.77), with two of the applicators employed for three or more years (SMR = 7.11, CI = 1.78, 28.42). No other cause of death was significantly elevated among lawn applicators as a group or among those employed for three or more years. Although based on very small numbers and perhaps due to chance, the NHL excess is consistent with several earlier studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 113380067; Zahm, Shelia Hoar 1; Affiliation:  1: From the Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Md.; Source Info: Nov1997, p1055; Number of Pages: 13p; Document Type: Article; Full Text Word Count: 7969
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107259178
T1  - Final regulations for the nutrition labeling of raw fruits, vegetables, and fish.
AU  - Pennington JAT
AU  - Wilkening VL
Y1  - 1997/11//
N1  - Accession Number: 107259178. Language: English. Entry Date: 19980501. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Food Labeling -- Legislation and Jurisprudence -- United States
KW  - Fruit
KW  - Fish
KW  - Vegetables
KW  - Government Regulations
KW  - United States Food and Drug Administration
KW  - United States
KW  - Food Analysis
SP  - 1299
EP  - 1305
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
IS  - 11
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Division of Nutrition Research Coordination, National Institute of Diabetes and Digestive and Kidney Disorders, National Institutes of Health, Natcher Bldg, 45 Center Drive, MSC 6600, Bethesda, MD 20892-6600
U2  - PMID: 9366869.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107303012
T1  - Integration of aging and cancer research in geriatric medicine.
AU  - Yancik R
Y1  - 1997/11//
N1  - Accession Number: 107303012. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9502837. 
KW  - Geriatrics
KW  - Oncologic Care
KW  - Aged
KW  - Neoplasms -- In Old Age
KW  - Program Planning
KW  - Research, Medical
SP  - m329
EP  - 32
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 52A
IS  - 6
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - Cancer Section, Geriatrics Program, National Institute on Aging (NIH), Gateway Building, Room 3E327, 7201 Wisconsin Avenue, MSC 9205, Bethesda, MD 20892-9205
U2  - PMID: 9402937.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107303012&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1997-42282-002
AN  - 1997-42282-002
AU  - Post, Robert M.
AU  - Denicoff, Kirk D.
AU  - Leverich, Gabriele S.
AU  - Frye, Mark A.
T1  - Drug-induced switching in bipolar disorder: Epidemiology and therapeutic implications.
JF  - CNS Drugs
JO  - CNS Drugs
JA  - CNS Drugs
Y1  - 1997/11//
VL  - 8
IS  - 5
SP  - 352
EP  - 365
CY  - New Zealand
PB  - Adis International
SN  - 1172-7047
SN  - 1179-1934
N1  - Accession Number: 1997-42282-002. Partial author list: First Author & Affiliation: Post, Robert M.; National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD, US. Other Publishers: Springer. Release Date: 19980401. Correction Date: 20120806. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Bipolar Disorder; Drug Therapy; Literature Review; Side Effects (Drug). Minor Descriptor: Epidemiology; Psychiatric Patients. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Methodology: Literature Review. Page Count: 14. Issue Publication Date: Nov, 1997. 
AB  - This review of studies of drug-induced switching in bipolar disorder presents findings on controversies regarding the existence of drug-induced switching, incidence of antidepressant-induced switching, and treatment options for patients at risk of drug- induced switching. Given the potential liabilities of the use of antidepressants in patients with bipolar disorder (e.g., cycle acceleration), it is unclear as to what is the most judicious treatment algorithm to follow for the bipolar patient with depression that is breaking through treatment with a mood stabiliser. In the absence of adequate studies. the authors' own algorithm is to use antidepressants judiciously in nonrapid cycling patients, but to relatively avoid them in rapid and ultra-rapid cyclers. Instead, they prefer to use adjunctively a 2nd mood stabiliser prior to the introduction of a unimodal antidepressant. Systematic controlled clinical trials are eagerly awaited, comparing not only the acute antidepressant efficacy of the newer antidepressants, but their liability in causing a switch or cycle induction when introduced into long term prophylaxis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - epidemiology & therapeutic implications of drug-induced switching
KW  - patients with bipolar disorder
KW  - literature review
KW  - 1997
KW  - Antidepressant Drugs
KW  - Bipolar Disorder
KW  - Drug Therapy
KW  - Literature Review
KW  - Side Effects (Drug)
KW  - Epidemiology
KW  - Psychiatric Patients
KW  - 1997
DO  - 10.2165/00023210-199708050-00002
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17578-009
AN  - 2004-17578-009
AU  - Newlin, David B.
T1  - Blood on the Tracks: Heroin Addiction.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1997/11//
VL  - 42
IS  - 11
SP  - 988
EP  - 990
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17578-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Newlin, David B.; Clinical Neurogenetics Section, Addiction Research Center, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, US. Release Date: 20041004. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Addiction; Drug Rehabilitation; Heroin. Minor Descriptor: AIDS; Experimentation; Psychological Theories; Social Control. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Platt, Jerome J. Heroin Addiction: Theory, Research, and Treatment, Vol. 2: The Addict, the Treatment Process, and Social Control=Malabar, FL: Krieger, 1995. 262 pp. $37.50; 1995. Platt, Jerome J. Heroin Addiction: Theory, Research, and Treatment, Vol. 3: Treatment Advances and AIDS=Malabar, FL: Krieger, 1995. 308 pp. $39.50; 1995. References Available: Y. Page Count: 3. Issue Publication Date: Nov, 1997. 
AB  - These two volumes (see record [rid]1995-99070-000[/rid] & [rid]1995-99078-000[/rid]) represent a virtual encyclopedia of sociomedical research on opiate--or more properly, polydrug--addiction. Volume 2 concerns factors related to the addict's career as a drug abuser, issues surrounding treatment, and sociolegal approaches to heroin addiction. Volume 3 discusses recent innovations in treatment of heroin addiction and the HIV-AIDS epidemic. The reviewer notes that an important contribution of these books is that they wed an objective overview of the literature with highly subjective and even provocative conclusions for how society might deal with the problem. However, also noted is a lack of graphs, tables, and critical review of the literature. More importantly, the volumes do not cover prevention of heroin abuse and addiction in a systematic manner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - heroin addiction
KW  - treatment
KW  - research
KW  - theory
KW  - addicts
KW  - AIDS
KW  - social control
KW  - 1997
KW  - Drug Addiction
KW  - Drug Rehabilitation
KW  - Heroin
KW  - AIDS
KW  - Experimentation
KW  - Psychological Theories
KW  - Social Control
KW  - 1997
U2  - Platt, Jerome J. (1995); Heroin Addiction: Theory, Research, and Treatment, Vol. 2: The Addict, the Treatment Process, and Social Control; Malabar, FL: Krieger, 1995. 262 pp. $37.50; 0-89464-267-7.
U2  - Platt, Jerome J. (1995); Heroin Addiction: Theory, Research, and Treatment, Vol. 3: Treatment Advances and AIDS; Malabar, FL: Krieger, 1995. 308 pp. $39.50; 0-89464-881-0.
DO  - 10.1037/001380
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39865-022
AN  - 2015-39865-022
AU  - Jöhren, Olaf
AU  - Sanvitto, Gilberto L.
AU  - Egidy, Giorgia
AU  - Saavedra, Juan M.
T1  - Angiotensin II AT1A receptor mRNA expression is induced by estrogen–progesterone in dopaminergic neurons of the female rat arcuate nucleus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/11//
VL  - 17
IS  - 21
SP  - 8283
EP  - 8292
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Jöhren, Olaf, Section on Pharmacology, National Institute of Mental Health, 10 Center Drive, MSC 1514, Building 10, Room 2D-57, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-39865-022. PMID: 9334403 Partial author list: First Author & Affiliation: Jöhren, Olaf; Section on Pharmacology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Angiotensin; Dopamine; Estradiol; Progesterone; Rats. Minor Descriptor: Prolactin; mRNA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 1997. Publication History: Accepted Date: Aug 20, 1997; Revised Date: Aug 11, 1997; First Submitted Date: Jun 16, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Brain angiotensin II (Ang II) inhibits pituitary prolactin release by an indirect mechanism requiring stimulation of dopamine formation and release. We report that [¹²⁵I]Sar¹–Ang II binding to AT₁ receptors and AT1A receptor mRNA expression increase selectively in the dorsomedial arcuate nucleus of 17β-estradiol-primed ovariectomized rats after treatment with progesterone. In hormone-treated rats, arcuate nucleus AT1A receptor mRNA expression is associated with tyrosine hydroxylase-positive neurons. No AT1A receptor mRNA was detected in tyrosine hydroxylase-positive cells of the arcuate nucleus of intact male rats. Conversely, in the anterior pituitary, where local or circulating Ang II stimulates prolactin release, [¹²⁵I]Sar1–Ang II binding to AT₁ receptors and AT1B receptor mRNA expression are decreased in 17β-estradiol/ progesterone-treated ovariectomized rats. Thus, AT1A receptors in the dorsal arcuate nucleus and AT1B receptors in the anterior pituitary are regulated inversely by estrogen/progesterone treatment, supporting the hypothesis of a dual role for brain and pituitary Ang II on prolactin release. The colocalization of AT1A receptor mRNA and tyrosine hydroxylase in neurons of the arcuate nucleus furthermore indicates that within this area central Ang II acts directly on dopaminergic neurons. These results support the hypothesis that central Ang II inhibits pituitary prolactin release indirectly via modulation of dopaminergic activity in the arcuate nucleus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - angiotensin II receptors
KW  - catecholamines
KW  - tyrosine hydroxylase
KW  - in situ hybridization
KW  - anterior pituitary
KW  - prolactin
KW  - 1997
KW  - Angiotensin
KW  - Dopamine
KW  - Estradiol
KW  - Progesterone
KW  - Rats
KW  - Prolactin
KW  - mRNA
KW  - 1997
U1  - Sponsor: National Council of Scientific and Technological Development, Brazil. Grant: 200794/94. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39865-042
AN  - 2015-39865-042
AU  - Widenfalk, Johan
AU  - Nosrat, Christopher
AU  - Tomac, Andreas
AU  - Westphal, Heiner
AU  - Hoffer, Barry
AU  - Olson, Lars
T1  - Neurturin and glial cell line-derived neurotrophic factor receptor-β (GDNFR-β), novel proteins related to GDNF and GDNFR-α with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/11//
VL  - 17
IS  - 21
SP  - 8506
EP  - 8519
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Olson, Lars, Department of Neuroscience, Karolinska Institutet, S-171 77, Stockholm, Sweden
N1  - Accession Number: 2015-39865-042. PMID: 9334423 Partial author list: First Author & Affiliation: Widenfalk, Johan; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. Release Date: 20160204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mice; Nerve Growth Factor; Neuroglia. Minor Descriptor: Cloning; Proteins. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Nov, 1997. Publication History: Accepted Date: Aug 25, 1997; Revised Date: Aug 18, 1997; First Submitted Date: Jun 20, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Cloning strategies were used to identify a gene termed glial cell line-derived neurotrophic factor receptor-β (GDNFR-β) related to GDNFR-α. In situ hybridization was then used to map cellular expression of the GDNF-related trophic factor neurturin (NTN) and GDNFR-β mRNA in developing and adult mice, and comparisons with GDNFR-α and RET were made. Neurturin is expressed in postnatal cerebral cortex, striatum, several brainstem areas, and the pineal gland. GDNFR-β mRNA was more widely expressed in the developing and adult CNS, including cerebral cortex, cerebellum, thalamus, zona incerta, hypothalamus, brainstem, and spinal cord, and in subpopulations of sensory neurons and developing peripheral nerves. NTN colocalized with RET and GDNFR-α in ureteric buds of the developing kidney. The circular muscle layer of the developing intestines, smooth muscle of the urether, and developing bronchiolae also expressed NTN. GDNFR-β was found in myenteric but not submucosal intestinal plexuses. In developing salivary glands NTN had an epithelial expression, whereas GDNFR-β was expressed in surrounding tissue. Neurturin and GDNFR-β were present in developing sensory organs. In the gonads, NTN appeared to be expressed in Sertoli cells and in the epithelium of the oviduct, whereas GDNFR-β was expressed by the germ cell line. Our findings suggest multiple roles for NTN and GDNFR-β in the developing and adult organism. Although NTN and GDNFR-β expression patterns are sometimes complementary, this is not always the case, suggesting multiple modi operandi of GDNF and NTN in relation to RET and the two binding proteins, GDNFR-α and GDNFR-β. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GDNF
KW  - neurturin
KW  - GDNFR a
KW  - GDNFR b
KW  - RET
KW  - in situ hybridization
KW  - CNS
KW  - development
KW  - kidney
KW  - gastrointestinal tract
KW  - gonads
KW  - kainic acid
KW  - GFRa 1
KW  - GFRa 2
KW  - 1997
KW  - Mice
KW  - Nerve Growth Factor
KW  - Neuroglia
KW  - Cloning
KW  - Proteins
KW  - 1997
U1  - Sponsor: Medical Research Council, Sweden. Grant: 14X-03185. Recipients: No recipient indicated
U1  - Sponsor: AMF. Recipients: No recipient indicated
U1  - Sponsor: AFA. Recipients: No recipient indicated
U1  - Sponsor: Petrus och Augusta Hedlunds Stiftelse. Recipients: No recipient indicated
U1  - Sponsor: United States Public Health Service, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39869-001
AN  - 2015-39869-001
AU  - Yajima, Shunsuke
AU  - Lammers, Claas-Hinrich
AU  - Lee, Sang-Hyeon
AU  - Hara, Yoshinobu
AU  - Mizuno, Keiko
AU  - Mouradian, M. Maral
T1  - Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF).
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/11//
VL  - 17
IS  - 22
SP  - 8657
EP  - 8666
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mouradian, M. Maral, Building 10, Room 5C116, 10 Center Drive, MSC 1406, Bethesda, MD, US, 20892-1406
N1  - Accession Number: 2015-39869-001. PMID: 9348334 Partial author list: First Author & Affiliation: Yajima, Shunsuke; Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Diseases and Stroke, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mice; Nerve Growth Factor; Rats; Brain Derived Neurotrophic Factor; Neuroglia. Minor Descriptor: Transcription Factors. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Nov, 1997. Publication History: Accepted Date: Aug 25, 1997; Revised Date: Aug 21, 1997; First Submitted Date: Mar 19, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - The potent neurotrophic factor glial cell-derived neurotrophic factor (GDNF) is a distant member of the transforming growth factor-b (TGF-b) superfamily of proteins. We report a transcription factor that is the first nuclear protein known to be induced by GDNF, thus designated murine GDNF inducible factor (mGIF). The cDNA was cloned in the course of investigating transcription factors that bind to Sp1 consensus sequences, using the in situ filter detection method, and it was found to encode a protein having the same C₂–H₂ zinc finger motif as Sp1. Sequence analysis indicated that mGIF is homologous to the human TGF-β inducible early gene (TIEG) and human early growth response gene-α (EGR-α). mGIF is widely distributed in the adult mouse with high mRNA levels in kidney, lung, brain, liver, heart, and testis. In the adult brain, mGIF is abundantly expressed in hippocampus, cerebral cortex, cerebellum, and amygdala with lower amounts in striatum, nucleus accumbens, olfactory tubercle, thalamus, and substantia nigra. During development, mGIF mRNA also has a wide distribution, including in cerebral cortex, cerebellar primordium, kidney, intestine, liver, and lung. GDNF induces the expression of mGIF rapidly and transiently both in a neuroblastoma cell line and in primary cultures of rat embryonic cortical neurons. Co-transfection of the Drosophila SL2 cells using mGIF expression plasmid and reporter constructs having Sp1 binding sites indicated that mGIF represses transcription from a TATA-containing as well as from a TATA-less promoter. These observations suggest that the zinc finger transcription factor mGIF could be important in mediating some of the biological effects of GDNF. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glial cell derived neurotrophic factor (GDNF)
KW  - zinc finger
KW  - Sp1
KW  - transcription
KW  - cloning
KW  - transforming growth factor-b (TGF-b)
KW  - 1997
KW  - Mice
KW  - Nerve Growth Factor
KW  - Rats
KW  - Brain Derived Neurotrophic Factor
KW  - Neuroglia
KW  - Transcription Factors
KW  - 1997
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39869-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39869-009
AN  - 2015-39869-009
AU  - Pozzo-Miller, Lucas D.
AU  - Pivovarova, Natalia B.
AU  - Leapman, Richard D.
AU  - Buchanan, Roger A.
AU  - Reese, Thomas S.
AU  - Andrews, S. Brian
T1  - Activity-dependent calcium sequestration in dendrites of hippocampal neurons in brain slices.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/11//
VL  - 17
IS  - 22
SP  - 8729
EP  - 8738
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Andrews, S. Brian, National Institutes of Health, Building 36, Room 2A-21, Bethesda, MD, US, 20892-4062
N1  - Accession Number: 2015-39869-009. PMID: 9348342 Partial author list: First Author & Affiliation: Pozzo-Miller, Lucas D.; Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160818. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Calcium Ions; Hippocampus; Endoplasmic Reticulum. Minor Descriptor: Dendrites; Synaptic Plasticity. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Nov, 1997. Publication History: Accepted Date: Sep 8, 1997; Revised Date: Aug 29, 1997; First Submitted Date: Jun 3, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Synaptic activity dependent changes in the spatio-temporal distribution of calcium ions regulate important neuronal functions such as dendritic integration and synaptic plasticity, but the processes that terminate the free Ca2+ transients associated with these changes remain unclear. We have characterized at the electron microscopic level the intracellular compartments involved in buffering free Ca2+ transients in dendritic cytoplasm of CA3 neurons by measuring the larger changes in the concentrations of total Ca that persist for several minutes after neuronal activity. Quantitative energy-dispersive x-ray microanalysis of cryosections from hippocampal slice cultures rapidly frozen 3 min after afferent synaptic activity identified a subset of dendritic endoplasmic reticulum (ER) as a highcapacity Ca2+ buffer. Calcium sequestration by cisterns of this subset of ER was graded, reversible, and dependent on a thapsigargin-sensitive Ca2+-ATPase. Sequestration was so robust that after repetitive high-frequency stimulation the Ca content of responsive ER cisterns increased as much as 20- fold. These results demonstrate that a subpopulation of ER is the major dendritic Ca sequestration compartment in the minutes after neuronal activity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - calcium regulation
KW  - calcium sequestration
KW  - hippocampus
KW  - CA3
KW  - dendrites
KW  - endoplasmic reticulum
KW  - synaptic activity
KW  - hippocampal slice cultures
KW  - X ray microanalysis
KW  - 1997
KW  - Calcium Ions
KW  - Hippocampus
KW  - Endoplasmic Reticulum
KW  - Dendrites
KW  - Synaptic Plasticity
KW  - 1997
U1  - Sponsor: National Institutes of Health, Intramural Research Program, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39869-009&site=ehost-live&scope=site
UR  - sba@helix.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 105819688
T1  - Somatropin for treating AIDS-related wasting syndrome.
AU  - Kakuda TN
Y1  - 1997/11/15/1997 Nov 15
N1  - Accession Number: 105819688. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023. 
KW  - Acquired Immunodeficiency Syndrome -- Complications
KW  - Cachexia -- Drug Therapy
KW  - Human Growth Hormone -- Therapeutic Use
KW  - Acquired Immunodeficiency Syndrome -- Economics
KW  - Cachexia -- Economics
KW  - Human Growth Hormone -- Adverse Effects
KW  - Human Growth Hormone -- Economics
SP  - 2618
EP  - 2620
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
JA  - AM J HEALTH SYST PHARM AJHP
VL  - 54
IS  - 22
CY  - Bethesda, Maryland
PB  - American Society of Health System Pharmacists
SN  - 1079-2082
AD  - Pharmacy Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
U2  - PMID: 9397228.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105819688&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107248257
T1  - Breast cancer survival and treatment in health maintenance organization and fee-for-service settings.
AU  - Potosky AL
AU  - Merrill RM
AU  - Riley GF
AU  - Taplin SH
AU  - Barlow W
AU  - Fireman BH
AU  - Ballard-Barbash R
Y1  - 1997/11/19/
N1  - Accession Number: 107248257. Language: English. Entry Date: 19980301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Mortality
KW  - Breast Neoplasms -- Therapy
KW  - Health Maintenance Organizations
KW  - Fee for Service Plans
KW  - Time Factors
KW  - Survival Analysis
KW  - Treatment Outcomes
KW  - California
KW  - Oregon
KW  - Comparative Studies
KW  - Chi Square Test
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Kaplan-Meier Estimator
KW  - Cox Proportional Hazards Model
KW  - Logistic Regression
KW  - Aged
KW  - Female
KW  - Human
SP  - 1683
EP  - 1691
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 89
IS  - 22
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, Executive Plaza North, Rm. 313, Bethesda, MD 20892-7344; e-mail: potosky@nih.gov
U2  - PMID: 9390537.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107248257&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107263806
T1  - Improved specificity of transesophageal dobutamine stress echocardiography compared to standard tests for evaluation of coronary artery disease in women presenting with chest pain.
AU  - Laurienzo JM
AU  - Cannon RO III
AU  - Quyyumi AA
AU  - Dilsizian V
AU  - Panza JA
Y1  - 1997/11/20/
N1  - Accession Number: 107263806. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; research; tables/charts; tracings. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0207277. 
KW  - Coronary Disease -- Diagnosis
KW  - Women's Health
KW  - Echocardiography, Transesophageal
KW  - Pharmacologic Stress Testing
KW  - Dobutamine -- Diagnostic Use
KW  - Angiography
KW  - Exercise Test, Cardiopulmonary
KW  - Radionuclide Imaging
KW  - Thallium -- Diagnostic Use
KW  - Sensitivity and Specificity
KW  - Chi Square Test
KW  - Statistical Significance
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Human
SP  - 1402
EP  - 1407
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
JA  - AM J CARDIOL
VL  - 80
IS  - 10A
CY  - Philadelphia, Pennsylvania
PB  - Elsevier Inc.
SN  - 0002-9149
AD  - Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9399711.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107263806&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107262220
T1  - Nosocomial infections in an oncology intensive care unit.
AU  - Velasco E
AU  - Thuler LCS
AU  - de S Martins CA
AU  - de Castro Dias LM
AU  - da S e C Goncalves VM
Y1  - 1997/12//1997 Dec
N1  - Accession Number: 107262220. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854. 
KW  - Immunocompromised Host
KW  - Cross Infection -- Epidemiology
KW  - Oncology Care Units
KW  - Disease Surveillance
KW  - Intensive Care Units
KW  - Epidemiological Research
KW  - Prospective Studies
KW  - Risk Factors
KW  - Descriptive Statistics
KW  - Correlational Studies
KW  - Correlation Coefficient
KW  - P-Value
KW  - Brazil
KW  - Cancer Patients
KW  - Infection Control
KW  - Academic Medical Centers
KW  - Catheters, Urinary -- Utilization
KW  - Central Venous Catheters -- Utilization
KW  - Catheter-Related Infections
KW  - Respiration, Artificial -- Utilization
KW  - Inpatients
KW  - Human
SP  - 458
EP  - 462
JO  - American Journal of Infection Control
JF  - American Journal of Infection Control
JA  - AM J INFECT CONTROL
VL  - 25
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - INTRODUCTION: Treatment of cancer has contributed to a growing number of immunocompromised patients with life-threatening nosocomial infections (NI). High mortality with considerable cost is observed when they are admitted to the intensive care unit (ICU). Few studies on infection control and surveillance have been undertaken in this population group. METHODS: All patients treated at a six-bed medical-surgical oncology ICU for > 48 hours were prospectively observed for the development of an NI and the influence of device utilization on infection rates. The analysis used the standard definitions of the National Nosocomial Infection Surveillance System Intensive Care Unit surveillance component. RESULTS: From September 1993 through November 1995, 370 infections occurred in 623 patients during 4034 patient-days, for an overall rate of 50.0 per 100 patients or 91.7 per 1000 patient-days. Pneumonia (28.9%), urinary tract infections (25.6%), and bloodstream infections (24.1%) were the main types of infection. The most common microorganisms isolated were Enterobacteriaceae (29.7%), fungi (22.2%), and Pseudomonas aeruginosa (13.2%). The median device utilization ratios were 0.63, 0.83, and 0.86 for ventilator, indwelling urinary catheter, and central venous catheter, respectively. The highest median device-specific associated infection rate was 41.7 for ventilator. The median for the average length of stay was 8.8 days, and the average severity of illness score was 4.0. There was a strong positive correlation between the overall NI patient rate and device utilization (r = 0.56, p < 0.01), average severity of illness score (r = 0.54, p < 0.01), and average length of stay (r = 0.67, p < 0.01). No correlations were statistically significant when patient-days were used in the denominator. Among the devices only the number of central venous catheter days was significantly correlated with infections (r = 0.51, p = 0.01). The NI patient-day rates were progressively higher the longer the patients stayed in the ICU. CONCLUSIONS: The high rates reported in this study may reflect a combination of several factors related to the underlying illness, neutrophil count, and exposure to invasive procedures. The adjusted infection rates described here provide specific surveillance data for further interhospital comparisons and also to assess the influence of invasive medical interventions, allowing the implementation of preventable measures to control infections.
SN  - 0196-6553
AD  - Infectious Disease Service, National Cancer Institute, Rio de Janeiro, Brazil
U2  - PMID: 9437483.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107262220&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Carrozza, V.;
AU  - Pucino, F.;
AU  - Grimes, G.;
AU  - Klippel, J.;
AU  - Turner, M.;
T1  - Pilot trial of topical thalidomide for the management of chronic discoid lupus erythematosus
CT  - Pilot trial of topical thalidomide for the management of chronic discoid lupus erythematosus
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1997/12/01/
VL  - 32
IS  - Dec
SP  - P
EP  - R
AD  - National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 34-12535; Language: English; Chemical Name: Thalidomide--50-35-1; Therapeutic Class: (84:00); AHFS Class: Topical preparations thalidomide (84:24); AHFS Class: Ointments thalidomide (92:00); AHFS Class: Immunosuppressive agents thalidomide; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Investigational Drugs; ToxicityDrug Metabolism and Body Distribution
N2  - This study will evaluate the safety, efficacy, and pharmacokinetics of topical thalidomide in patients with chronic discoid lupus erythematosus (CDLE) refractory to conventional therapy. Seventeen subjects with CDLE will participate in this 12-week double-masked pilot trial to evaluate the effects of topical thalidomide on clinical appearance, histologic findings, and cytokine profiles of skin lesions. Following baseline assessment of outcome parameters, patients will apply topical thalidomide 20% ointment once daily to an affected area and placebo to a second similar lesion for an 8 week treatment phase. Outcome measures will be assessed at weeks 2, 4, and 8, and following a 4 week wash-out period. Topical application of thalidomide may minimize systemic toxicities associated with this agent while maintaining therapeutic effectiveness.
KW  - Thalidomide--lupus erythematosus-;
KW  - Practice Interest Areas--Drug Information/Toxicology/Investigational Drugs--meeting presentations;
KW  - ASHP meeting abstracts--thalidomide, discoid lupus erythematosus;
KW  - Pharmacokinetics--thalidomide--discoid lupus erythematosus;
KW  - Blood levels--thalidomide--discoid lupus erythematosus;
KW  - Dosage--thalidomide--discoid lupus erythematosus;
KW  - Topical preparations--thalidomide--discoid lupus erythematosus;
KW  - Ointments--thalidomide--discoid lupus erythematosus;
KW  - Toxicity--thalidomide;
KW  - Immunosuppressive agents--thalidomide--discoid lupus erythematosus;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=34-12535&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Biescker, B.;
T1  - Primer on genetic counseling
CT  - Primer on genetic counseling
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1997/12/01/
VL  - 32
IS  - Dec
SP  - PI
EP  - 11
AD  - National Human Genome Research Institute, Bethesda, MD 20814, USA
N1  - Accession Number: 34-12816; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics
N2  - The Human Genome Project will identify genes that can cause human disease. Tests for these genes will become available. The public will have to decide whether or not to take these tests and genetic counseling needs to be available to inform these people about the potential medical and psychological consequences of these tests. Institutions should develop genetic counseling protocols consisting of: 1) precounseling education and assessment; 2) a multidisciplinary approach; and, 3) follow-up services for the medical and psychological management of the patients identified as being at increased risk for a disease. Maintaining patient privacy should be an integral part of the counseling efforts. Learning objectives: 1. Discuss the need for genetic counseling services. 2. Describe the elements that should be included in a genetic counseling program. 3. List the various genetic counseling methods. Self-assessment questions: True or False: 1. Genetic counseling should only happen after a person is identified at increased risk. 2. Genetic testing can affect family relationships. 3. Genetic counselor training programs are available. Answers: 1. F; 2. T; 3. T.
KW  - ASHP meeting abstracts--Human Genome Project;
KW  - Genetics--patient information--consultation;
KW  - Guidelines--patient information--genetics consultation;
KW  - Human Genome Project--patient information--genetics consultation;
KW  - Patient information--consultation--genetics;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=34-12816&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
T1  - Role of the Internet in contemporary practice
CT  - Role of the Internet in contemporary practice
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1997/12/01/
VL  - 32
IS  - Dec
SP  - PI
EP  - 70
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1N-257, 10 Center Drive, Bethesda, MD 20892-1196, USA
N1  - Accession Number: 34-12930; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Information Processing and Literature
N2  - The Internet is a vast and virtually limitless resource that has revolutionized the worldwide dissemination of information. This communications tool allows ready access to a growing collection of information about an array of topics, including medicine, drug therapy, and public health. The Internet can be used to monitor medical advances and efficiently retrieve and exchange information about patient care, teaching, and research. While it is a rich information source of unquestionable value, the Internet complements but does not replace conventional resources. Moreover, the Internet has some limitations and remains a work in progress. Learning objectives: 1. List the types of information that are accessible via the Internet. 2. Describe how the Internet can be used in support of routine patient care. 3. List the major limitations of the Internet. Self-assessment questions: True or False: 1. Bibliographic data bases, unlike factual and directory data bases, are not accessible via the Internet. 2. The Internet should always be the first resource used in a systematic search of the literature. 3. Poor accountability is one of the possible limitations of information accessed via the Internet. Answers: 1. F; 2. F; 3. T.
KW  - ASHP meeting abstracts--Internet;
KW  - Internet--overview;
KW  - Information--Internet;
KW  - Computers--Internet;
KW  - Pharmacy--Internet--applications;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=34-12930&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Pau, A. K.;
T1  - Therapeutic management of HIV-infected women (with emphasis on pregnant HIV women)
CT  - Therapeutic management of HIV-infected women (with emphasis on pregnant HIV women)
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1997/12/01/
VL  - 32
IS  - Dec
SP  - PI
EP  - 22
AD  - National Institutes of Health, Clinical Center Pharmacy Department, Building 10, Room 1N 257, 10 Center Drive, MSC 1196, Bethesda, MD 20892-1196, USA Internet: apau@nih.gov
N1  - Accession Number: 34-12693; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - Women are among the fastest growing patient population infected with HIV in the United States. Although female HIV patients can have similar complications as males, several gender specific manifestations have been identified. Recognition of these complications can aid in prompt diagnosis and treatment. Management of pregnant HIV infected women remains a challenge. One has to balance the benefits of treatment for HIV infection and complications with the lack of safety data of drugs transferred to fetuses. Antiretroviral therapy during pregnancy serves two major purposes: treatment of maternal HIV infection and prevention of vertical transmission. Zidovudine has been shown to be effective in reducing maternal HIV transmission. The role and current recommendations for combination antiretroviral therapy during pregnancy will be discussed. Learning objectives: 1. List two major gynecological complications commonly seen in HIV infected women. 2. List three factors associated with increased risk of maternal HIV transmission. 3. Recite the current recommendations of usage of antiretroviral therapy during pregnancy. Self-assessment questions: True or False: 1. Invasive cervical neoplasia in HIV infected women is considered as an AIDS-defining condition. 2. Anti-tuberculosis therapy should be delayed until after delivery in a pregnant woman with pulmonary tuberculosis. 3. Stavudine, lamivudine, and indinavir used in combination beginning at the second trimester of pregnancy have been shown to reduce maternal HIV transmission by 30%. Answers: 1. T; 2. F; 3. F.
KW  - ASHP meeting abstracts--HIV infections;
KW  - Antivirals--HIV infections--women;
KW  - HIV infections--women--therapy;
KW  - Pregnancy--HIV infections--therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=34-12693&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107238952
T1  - Cardiovascular anatomy and physiology in the female.
AU  - Wingate S
Y1  - 1997/12//1997 Dec
N1  - Accession Number: 107238952. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8912620. 
KW  - Cardiovascular System Physiology
KW  - Women's Health
KW  - Cardiovascular System -- Anatomy and Histology
KW  - Sex Factors
KW  - Female
KW  - Exercise Physiology
KW  - Electrocardiography
KW  - Lipoproteins
KW  - Hemostasis
KW  - Estrogens
KW  - Heart
KW  - Male
SP  - 447
EP  - 452
JO  - Critical Care Nursing Clinics of North America
JF  - Critical Care Nursing Clinics of North America
JA  - CRIT CARE NURS CLIN NORTH AM
VL  - 9
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Important differences in male and female cardiovascular anatomy and physiology may account for many of the gender differences seen in various cardiac disease states. Predominant influences on female disease manifestations include (1) women's smaller body size, hence smaller hearts and smaller coronary vessels and (2) women's fluctuating levels of estrogen throughout their lifespan. Understanding these critical anatomic and physiologic differences allows the clinician to better predict and plan care for women. For example, knowing that women generally have a smaller body surface area than men allows one to better understand why men have higher creatine kinase (CK) values than do women--an important distinction when interpreting these values in the acute care setting. The fact that women's hearts and coronary vessels are generally smaller than men's also helps one undrstand why women have a higher inhospital mortality than men post-coronary artery bypass graft surgery (see article by Allen in this issue for more detailed information on revascularization). These are only a few examples of the many opportunities that acute care nurses have to integrate their knowledge of anatomy and physiology into proactive planning for their female cardiac patients. Copyright (c) 1997 W.B. Saunders Company
SN  - 0899-5885
AD  - Critical and Acute Care Patient Services, Warren Grant Magnuson Clinical Center, The National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9444167.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107238952&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107238962
T1  - Detection of coronary artery disease in women: the pitfalls of noninvasive tests.
AU  - Laurienzo JM
Y1  - 1997/12//1997 Dec
N1  - Accession Number: 107238962. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8912620. 
KW  - Coronary Disease -- Diagnosis
KW  - Women
KW  - Noninvasive Procedures
KW  - Women's Health
KW  - Sex Factors
KW  - Electrocardiography
KW  - Coronary Angiography
KW  - Radionuclide Imaging
KW  - Thallium
KW  - Echocardiography
KW  - Exercise Test, Cardiopulmonary
KW  - Gender Bias
KW  - Male
KW  - Female
SP  - 469
EP  - 475
JO  - Critical Care Nursing Clinics of North America
JF  - Critical Care Nursing Clinics of North America
JA  - CRIT CARE NURS CLIN NORTH AM
VL  - 9
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Even though coronary artery disease is the leading cause of death in women, a diagnostic dilemma still remains owing to the high rate of false-positive results observed with noninvasive testing. It still is not clear why a gender bias exists in the noninvasive and invasive evaluation of women suspected of coronary artery disease. Probability analysis may reduce the number of unnecessary coronary angiographies in women, thus setting up a sex-specific approach. Stress echocardiography studies have shown no sex differences in the cardiac response to this test. Because of the greater specificity of this test, some groups have suggested that stress echocardiography could be the initial test of choice in women, and justifiable on cost analysis. Copyright (c) 1997 W.B. Saunders Company
SN  - 0899-5885
AD  - National Institutes of Health, 10 Center Drive, MSC 1650, Building 10, Room 7B-15, Bethesda, MD 20892-1650
U2  - PMID: 9444170.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105821319
T1  - Update: transmission of HIV-1 from mother to child.
AU  - Fowler MG
Y1  - 1997/12//1997 Dec
N1  - Accession Number: 105821319. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007264. 
KW  - Disease Transmission, Vertical
KW  - HIV Infections -- Transmission
KW  - HIV-1
KW  - Breast Feeding
KW  - Europe
KW  - Female
KW  - Fetus
KW  - HIV Infections -- Drug Therapy
KW  - HIV Infections -- Epidemiology
KW  - Incidence
KW  - Infant, Newborn
KW  - Placenta -- Physiology
KW  - Practice Guidelines
KW  - Pregnancy Complications, Infectious -- Epidemiology
KW  - Pregnancy
KW  - Risk Factors
KW  - United States Public Health Service
KW  - United States
KW  - Zidovudine -- Therapeutic Use
SP  - 343
EP  - 348
JO  - Current Opinion in Obstetrics & Gynecology
JF  - Current Opinion in Obstetrics & Gynecology
JA  - CURR OPIN OBSTET GYNECOL
VL  - 9
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Mother-to-child transmission near the time of birth is the primary route of HIV-1 infection among infants and young children. Throughout the world, 1000 babies a day become infected with HIV, and cumulative global estimates are that 3 million children have been infected since the HIV pandemic began. Although major advances have been made in reducing mother-to-child transmission of HIV-1 in the USA and Europe through the use of an intensive regimen of zidovudine, many research questions remain unresolved. These include (1) viral and host characteristics which hinder or facilitate perinatal HIV transmission (i.e. the role played by viral load, the placenta and obstetric risk factors); (2) the proportion of transmission occurring in utero, intrapartum or during the breast feeding period; and (3) the mode of action of the successful zidovudine regimen. Studies published within the past year have shed light on several of these research topics. In 1996-1997 a number of important studies were published which support a general correlation between maternal viral load and infant HIV infection. The most recent studies do not, however, support the theory that there is a threshold below which transmission cannot occur, and also indicate that zidovudine, given according to the US Public Health Service guidelines, can significantly reduce the risk of transmission across all levels of maternal viral load. Analyses of viral load data from the successful clinical trial with zidovudine (AIDS Clinical Trial Group 076) suggest that its primary action is not by reducing the viral load, and raise the possibility that administering antiretroviral prophylaxis to the infant at the time of highest exposure may be another reason for the reduction in transmission. Obstetric risk factors for mother-to-child HIV transmission have been evaluated in several large cohort studies. A duration of membrane rupture of more than 4 h, and procedures such as amniocentesis, preterm labor, and the presence of sexually transmitted diseases during pregnancy were found to be significant risk factors. Still unresolved is the potential protective effect of cesarean section in reducing the risk of transmission. Likewise, the role played by the placenta in preventing or facilitating perinatal transmission is not well understood, and requires further research. This year did see the publication of consistent findings from diverse geographical regions regarding the probable timing of perinatal HIV transmission. On the basis of the timing of the first infant positive polymerase chain reaction or culture, most transmission would appear to occur around the intrapartum or very late prenatal period, and only approximately 12-14% is related to breast feeding. These advances should help focus and refine future research efforts to reduce mother-to-child HIV transmission worldwide.
SN  - 1040-872X
AD  - Efficacy Trials Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20892, USA.
U2  - PMID: 9425574.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Jiemin Wong
AU  - Qiao Li
AU  - Ben-Zion Levi
AU  - Yun-Bo Shi
AU  - Wolffe, Alan P.
T1  - Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/12//12/1/97
VL  - 16
IS  - 23
M3  - Article
SP  - 7130
EP  - 7145
SN  - 02614189
AB  - The Xenopus thyroid hormone receptor βA (TRA) gene contains an important thyroid hormone response element (TRE) that is assembled into a positioned nucleosome. We determine the translational position of the nucleosome containing the TRE and the rotational positioning of the double helix with respect to the histone surface. Histone H1 is incorporated into the nucleosome leading to an asymmetric protection to micrococcal nuclease cleavage of linker DNA relative to the nucleosome core. Histone H1 association is without significant consequence for the binding of the heterodimer of thyroid hormone receptor and 9-cis retinoic acid receptor (TR/RXR) to nucleosomal DNA in vitro, or for the regulation of TRβA gene transcription following microinjection into the oocyte nucleus. Small alterations of 3 and 6 bp in the translational positioning of the TRE in chromatin are also without effect on the transcriptional activity of the TRβA gene, whereas a small change in the rotational position of the TRE (3 bp) relative to the histone surface significantly reduces the binding of TR/RXR to the nucleosome and decreases transcriptional activation directed by TR/RXR. Our results indicate that the specific architecture of the nucleosome containing the TRE may have regulatory significance for expression of the TRβA gene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTONES
KW  - THYROID hormones
KW  - HORMONE receptors
KW  - CHROMATIN
KW  - DNA
KW  - NUCLEAR receptors (Biochemistry)
KW  - TRETINOIN
KW  - chromatin structure
KW  - linker histones
KW  - nuclear receptors
KW  - nucleosome positioning
KW  - transcriptional regulation
N1  - Accession Number: 13005884; Jiemin Wong 1 Qiao Li 1 Ben-Zion Levi 2 Yun-Bo Shi 1 Wolffe, Alan P. 1; Email Address: awlme@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Building, 18T, Room 106, Bethesda, MD, USA  2: Department of Food Engineering and Biotechnology, Technion, Haifa, Israel; Source Info: 12/1/97, Vol. 16 Issue 23, p7130; Subject Term: HISTONES; Subject Term: THYROID hormones; Subject Term: HORMONE receptors; Subject Term: CHROMATIN; Subject Term: DNA; Subject Term: NUCLEAR receptors (Biochemistry); Subject Term: TRETINOIN; Author-Supplied Keyword: chromatin structure; Author-Supplied Keyword: linker histones; Author-Supplied Keyword: nuclear receptors; Author-Supplied Keyword: nucleosome positioning; Author-Supplied Keyword: transcriptional regulation; Number of Pages: 16p; Document Type: Article
L3  - 10.1093/emboj/16.23.7130
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rai, Sadananda S.
AU  - Wolff, J.
T1  - Vinblastine-induced formation of tubulin polymers is electrostatically regulated and nucleated.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1997/12//12/1/97
VL  - 250
IS  - 2
M3  - Article
SP  - 425
EP  - 431
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Vinblastine promotes tubulin polymerization as measured by turbidity at 400 nm. Unlike microtubule assembly, this mode of polymerization does not require GTP and, in fact, GTP inhibits polymerization, as do other G nucleotides in the potency order: GtetraP≥GTP > GDP > GMP > no nucleotide. Inhibition is not nucleoside-specific as ATP, ADP, and CTP also inhibit, and inorganic oligophosphates are as inhibitory as nucleotides in the order tetraphosphate ≈ triphosphate > pyrophosphate [This symbol cannot be presented in ASCII format] phosphate. Inhibition of polymerization is a rough function of the number of anionic charges and can be mimicked by suramin or tartrate. It is not due to sequestration of magnesium or to debinding of vinblastine. The anion induced decrease in turbidity generation is reflected in the amount of tubulin that is pelletable, but even in the absence of turbidity significant pelletable tubulin persists which can be assessed by 90° light scattering. Formation of this polymer is less sensitive to anions. Shearing of GTP-inhibited and vinblastine-induced samples promotes turbidity and addition of seeds made from vinblastine polymers leads to rapid increases in turbidity in a concentration-dependent manner. Adjustment of the vinblastine concentration permits the demonstration of a latent period for polymerization that can be shortened by polymer seeds. Vinblastine-induced polymerization shows a critical concentration, and, in the presence of GTP, two distinct critical concentrations call be identified. We conclude that charge-charge interactions play a significant role in the formation of vinblastine-induced polymers, and that their formation is a two-step process resembling a nucleation/elongation mechanism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VINBLASTINE
KW  - POLYMERIZATION
KW  - LIGHT -- Scattering
KW  - MICROTUBULES
KW  - NUCLEOSIDES
KW  - BIOCHEMISTRY
KW  - critical concentration
KW  - light scattering
KW  - oligoanion
KW  - polymerization
KW  - vinblastine
N1  - Accession Number: 13706207; Rai, Sadananda S. 1 Wolff, J. 1; Affiliation:  1: Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: 12/1/97, Vol. 250 Issue 2, p425; Subject Term: VINBLASTINE; Subject Term: POLYMERIZATION; Subject Term: LIGHT -- Scattering; Subject Term: MICROTUBULES; Subject Term: NUCLEOSIDES; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: critical concentration; Author-Supplied Keyword: light scattering; Author-Supplied Keyword: oligoanion; Author-Supplied Keyword: polymerization; Author-Supplied Keyword: vinblastine; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bishop, Jack B.
AU  - Morris, Richard W.
AU  - Seely, John C.
AU  - Hughes, Lori A.
AU  - Cain, K. T.
AU  - Generoso, Walderico M.
T1  - Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics1.
JO  - Fundamental & Applied Toxicology
JF  - Fundamental & Applied Toxicology
Y1  - 1997/12//
VL  - 40
IS  - 2
M3  - Article
SP  - 191
EP  - 204
PB  - Oxford University Press / USA
SN  - 02720590
AB  - Chemicals, by virtue of their varied interactions with biological molecules, are expected to differ in the way they may alter female reproduction. Reproductive toxicity may reflect effects either on the female germ cells or on various maternal processes such as ovulation, implantation, pregnancy, and parturition. In either case, the ultimate manifestation of chemical toxicity on female reproduction is a decrease in the number of normal young born. Very little information is available on the effects of chemicals that are nonhormonal in nature on the long-term ability of treated females to produce offspring. This report presents the results of long-term female total reproductive capacity (TRC) tests on 29 chemicals, including pharmaceuticals, pesticides, and alkylating and industrial agents. For each chemical, the minimum test involved an evaluation of the maximum tolerated dose administered as a single intraperitoneal injection. Females were single-pair mated with an untreated male for most of the female's reproductive life span (a minimum of 347 days posttreatment) and scored for the number of live births produced during this period. Confirmatory dominant lethal experiments or histological examinations for numbers of small follicles were carried out when mutagenic effects or cytotoxicity, respectively, were suspected as the basis for reduced fertility. Of the 29 chemicals studied, 17 had reproductive effects which may be grouped into one of three classes: (1) those that reduced the total number of young and litters per female, (2) those that reduced the total number of young but not of litters, and (3) those that had no significant effect on the total number of young produced but reduced the size of the first and/or second litters. The TRC provides a capacity for detecting a range of toxic insults upon female reproduction. Many of the chemicals were indeed shown to affect the reproductive performance of females through mutagenic and/or cytotoxic effects on follicles. In some cases, however, no causative mechanism could be identified for the observed reduction in reproductive performance. Nevertheless, with this report the number of chemicals tested by this TRC procedure has been quadrupled and the categories of chemicals tested have been substantially broadened. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Xenobiotics
KW  - Toxicological chemistry
KW  - Mice as laboratory animals
KW  - Female reproductive organs
KW  - Fertility
KW  - Mutagenesis
KW  - female mice
KW  - fertility
KW  - follicles
KW  - litter size
KW  - oocytes
KW  - ovarian histology
KW  - reproductive toxicology
N1  - Accession Number: 82422194; Bishop, Jack B. 1; Morris, Richard W. 2; Seely, John C. 3; Hughes, Lori A. 4; Cain, K. T. 4; Generoso, Walderico M. 4; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; 2: † Analytical Sciences, Inc.; 3: ‡ PATHCO, Inc., Research Triangle Park North Carolina 27709; 4: ‡ Oak Ridge National Laboratory Oak Ridge, Tennessee 37830; Issue Info: 1997, Vol. 40 Issue 2, p191; Thesaurus Term: Xenobiotics; Thesaurus Term: Toxicological chemistry; Subject Term: Mice as laboratory animals; Subject Term: Female reproductive organs; Subject Term: Fertility; Subject Term: Mutagenesis; Author-Supplied Keyword: female mice; Author-Supplied Keyword: fertility; Author-Supplied Keyword: follicles; Author-Supplied Keyword: litter size; Author-Supplied Keyword: oocytes; Author-Supplied Keyword: ovarian histology; Author-Supplied Keyword: reproductive toxicology; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Vliagoftis, H.
AU  - Metcalfe, D. D.
T1  - Characterization of adhesive interactions between mast cells and laminin isoforms: evidence of a principal role for α6 integrin.
JO  - Immunology
JF  - Immunology
Y1  - 1997/12//
VL  - 92
IS  - 4
M3  - Article
SP  - 553
EP  - 560
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Mast cells are known to adhere to laminin, although there is limited information on the characteristics of this event. To further examine this adhesive interaction, we thus determined the adherence of murine mast cell lines and primary bone marrow cultured mast cells (BMCMC) to murine laminin (mLN), human placental laminin-1 (hLN), merosin (laminin-2) and various laminin fragments, concentrating on activating stimuli, the involvement of integrins, and the effect on mast cell activation. Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc∊RI aggregation or addition of stem cell factor (SCF). Adhesion to laminin was partially inhibited by soluble E8 and PA22-2, both fragments of laminin that promote mast-cell adhesion when bound on surfaces. Mast-cell lines and BMCMC consistently expressed high levels of α6 integrin. Antibody to α6 blocked spontaneous and inhibited activated mast-cell adhesion to hLN, and inhibited mast-cell adhesion to mLN and its fragment E8. Mast-cell adhesion to both laminin isoforms increased Fc∊RI-mediated mast-cell secretion. These observations demonstrate that mast- cell attachment to laminin is promoted by physiological stimuli, is mediated principally by α6 integrin, and results in enhanced cell activation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAST cells
KW  - CELL adhesion
KW  - CELL lines
KW  - BONE marrow
KW  - PHORBOLS
KW  - INTEGRINS
KW  - STEM cells
N1  - Accession Number: 13992574; Vliagoftis, H. 1 Metcalfe, D. D. 1; Affiliation:  1: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, MD, USA.; Source Info: Dec97, Vol. 92 Issue 4, p553; Subject Term: MAST cells; Subject Term: CELL adhesion; Subject Term: CELL lines; Subject Term: BONE marrow; Subject Term: PHORBOLS; Subject Term: INTEGRINS; Subject Term: STEM cells; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107209093
T1  - Socioeconomic and racial/ethnic factors affecting non-fatal medically attended injury rates in US children.
AU  - Overpeck MD
AU  - Jones DH
AU  - Trumble AC
AU  - Scheidt PC
AU  - Bijur PE
Y1  - 1997/12//
N1  - Accession Number: 107209093. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056. 
KW  - Wounds and Injuries -- Epidemiology -- In Infancy and Childhood
KW  - Wounds and Injuries -- Epidemiology -- United States
KW  - Child Safety
KW  - Socioeconomic Factors
KW  - Race Factors
KW  - Health Services Accessibility
KW  - United States
KW  - Survey Research
KW  - Multiple Linear Regression
KW  - Univariate Statistics
KW  - Confidence Intervals
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Descriptive Statistics
KW  - Relative Risk
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Human
SP  - 272
EP  - 276
JO  - Injury Prevention (1353-8047)
JF  - Injury Prevention (1353-8047)
JA  - INJ PREV
VL  - 3
IS  - 4
PB  - BMJ Publishing Group
AB  - OBJECTIVE: Using a representative survey of US children, the purpose was to evaluate separate effects of socioeconomic and racial/ethnic factors, including access to care, on medically attended non-fatal injury rates. METHODS: Multivariate linear regression models were used to determine associations between injuries and health care coverage (insurance or Medicaid), having a place to go for care, race/ethnicity, maternal education, number of adults and children in the household, poverty, and urbanicity. The 1988 Child Health Supplement to the National Health Interview Survey included questions on medically attended injuries, and their cause, location, and effects on the child. Injury categories included total, consequential, occurrence at home or school, falls, and being struck or cut. RESULTS: Lack of health care coverage was consistently associated with lower medically attended injury rates in non-Hispanic blacks or whites and Mexican-Americans, but affected total rates for each group differently due to unequal distribution of health care coverage. Injuries occurred about 40% more frequently to children and adolescents living in single adult households compared with two adult homes for all injury categories except for injuries occurring at school. CONCLUSIONS: Preventive interventions targeted to specific populations based on assumptions that poverty, lack of education, or minority status result in greater risks for injuries require a closer look. Efficient targeting should address underlying factors such as differences in exposures and environments associated with single adult homes or recreational activities. Data sources used to target high risk populations for interventions need to address bias due to access to care.
SN  - 1353-8047
AD  - Epidemiology Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Bethesda, MD 20892
U2  - PMID: 9493623.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107287589
T1  - Microtremors during a sustained concentration task from boys previously exposed to opiates in-utero.
AU  - Spencer J
AU  - Suess P
AU  - Better W
AU  - Herning RI
Y1  - 1997/12//
N1  - Accession Number: 107287589. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9439517. 
KW  - Infant, Drug-Exposed
KW  - Tremor -- In Infancy and Childhood
KW  - Fingers
KW  - Data Analysis, Statistical
KW  - Purposive Sample
KW  - Interviews
KW  - Quantitative Studies
KW  - Child
KW  - Male
KW  - Human
SP  - 53
EP  - 63
JO  - Journal of Child & Adolescent Substance Abuse
JF  - Journal of Child & Adolescent Substance Abuse
JA  - J CHILD ADOLESC SUBST ABUSE
VL  - 7
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - Fourteen boys who were exposed to opiates in-utero (drug exposed) maintained their index finger in a static, weightforced position while attempting to maintain a stylus at a fix point producing intentional microtremors. After 2.5 minutes, significant increases in tremor were recorded in mean peak (6 Hz) amplitude while accuracy of sustaining this response was significantly reduced. Age matched boys (ages 7-12) who were raised in an environment in which drugs were used but were not directly exposed in-utero (lifestyle group N = 13) or a standard control group (N = 12), did not show similar changes over time. Resting or postural-extended tremor did differ among groups. Alcohol, marihuana, or tobacco usage by the mother or birth weight of the child did not predict subsequent group differences in tremor. Both biological and environmental variables plus type and sensitivity of measurement used are critical elements for describing long-term, potential residual drug effects in children, especially as they relate to sustained attention.
SN  - 1067-828X
AD  - Molecular Neuropsychiatry Section, Division of Intramural Research, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107268361
T1  - Comments from the NIH.
AU  - Marler J
Y1  - 1997/12//1997 Dec
N1  - Accession Number: 107268361. Language: English. Entry Date: 19980701. Revision Date: 20150818. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8603596. 
KW  - Stroke -- Drug Therapy
KW  - Cerebral Ischemia
KW  - Plasminogen Activators -- Therapeutic Use
KW  - Emergency Care
KW  - Education, Continuing (Credit)
KW  - Time Factors
SP  - 350
EP  - 350
JO  - Journal of Neuroscience Nursing
JF  - Journal of Neuroscience Nursing
JA  - J NEUROSCI NURS
VL  - 29
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0888-0395
AD  - Project Officer, National Institutes of Health, National Institute of Neurological Diseases and Stroke
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107261098
T1  - Derivation of daily values used for nutrition labeling.
AU  - Pennington JA
AU  - Hubbard VS
Y1  - 1997/12//
N1  - Accession Number: 107261098. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Food Labeling
KW  - Food
KW  - Nutritional Requirements
KW  - Government Regulations
KW  - United States Food and Drug Administration
SP  - 1407
EP  - 1412
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 97
IS  - 12
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Division of Nutrition Research Coordinator, National Institutes of Health, Natcher Bldg, Rm 5AN32, 45 Center Dr, MSC 6000, Bethesda, MD 20892-6000
U2  - PMID: 9404338.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107282804
T1  - Older women and hormone replacement therapy: factors influencing late life initiation.
AU  - Leveille SG
AU  - LaCroix AZ
AU  - Newton KM
AU  - Keenan NL
Y1  - 1997/12//12/ 1/1997
N1  - Accession Number: 107282804. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Grant U48/CCU009654 from the Centers for Disease Control and Prevention. NLM UID: 7503062. 
KW  - Hormone Replacement Therapy -- Psychosocial Factors
KW  - Hormone Replacement Therapy -- Utilization
KW  - Chi Square Test
KW  - Odds Ratio
KW  - Logistic Regression
KW  - Age Factors
KW  - Attitude to Health
KW  - Cross Sectional Studies
KW  - Questionnaires
KW  - Funding Source
KW  - Aged
KW  - Female
KW  - Human
SP  - 1496
EP  - 1500
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVE: To describe factors associated with initiation of hormone replacement therapy (HRT) by older women. DESIGN: A cross-sectional study of 671 randomly selected women aged 65 to 80 who participated in a larger telephone survey on preventive health behaviors. SETTING: A large health maintenance organization (HMO) in Seattle, Washington. PARTICIPANTS: Of the 521 women who responded (78%), 51 had begun taking HRT at age 60 or older and were identified as initiators. Women who had never used HRT or past users who had begun HRT before age 60 were classified as noninitiators (n = 362). Current users who started HRT before age 60 (n = 108) were excluded. MEASUREMENTS: Sources included the telephone survey, automated HMO pharmacy data, and HMO utilization and provider databases. RESULTS: Initiators were similar to noninitiators with respect to age, marital status, education, and health status. Initiators were more likely to have had a hysterectomy at age 60 or later than noninitiators. Sixty-two percent of the non-initiators said they had received no information about the benefits of HRT from their providers compared with 18% of initiators. HRT initiation was associated with belief in prevention benefits of HRT for fractures and cardiovascular disease and with reported encouragement from the physician to use HRT. CONCLUSIONS: Other than hysterectomy status, there were few sociodemographic or health characteristics that markedly distinguished older initiators from noninitiators. Our findings show the importance of physician counseling in an older woman's decision to initiate HRT.
SN  - 0002-8614
AD  - National Institute on Aging, 7201 Wisconsin Avenue, Suite 3C-309, Bethesda, MD 20892
U2  - PMID: 9400560.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107282804&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107279538
T1  - Nurses of color -- a legacy of healing.
AU  - House K
Y1  - 1997/12//1997 Dec 1
N1  - Accession Number: 107279538. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Nursing; USA. NLM UID: 9892046. 
KW  - History of Nursing -- United States
KW  - Blacks -- History -- United States
KW  - United States
SP  - 10
EP  - 10
JO  - Nursing Spectrum -- Illinois & Indiana Edition
JF  - Nursing Spectrum -- Illinois & Indiana Edition
JA  - NURS SPECTRUM (CHICAGO ILLINOIS INDIANA)
VL  - 10
IS  - 24
CY  - Falls Church, VA 22042, Illinois
PB  - Gannett Healthcare Group
AD  - Georgetown University Surgical Services Department, National Institutes of Health, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107279538&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Portier, C.
AU  - El Masri, H.
T1  - Statistical research needs in mechanistic modelling for carcinogenic risk assessment.
JO  - Statistical Methods in Medical Research
JF  - Statistical Methods in Medical Research
Y1  - 1997/12//
VL  - 6
IS  - 4
M3  - journal article
SP  - 305
EP  - 315
PB  - Sage Publications, Ltd.
SN  - 09622802
AB  - If the broad spectrum of mechanistic research conducted on an environmental carcinogen is to be used in quantifying cancer risks, statisticians must play a key role. Statistical methods are critically needed for a scientifically valid analysis of a complicated series of linked experimental findings. This will require a greater understanding of the underlying biology than is common in statistical consulting, aiding in the development of complicated mechanistically based mathematical descriptions of mean response and in the creation of statistical methods for the estimation of model parameters (e.g. likelihoods) able to use both the underlying model and much of the available data. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARCINOGENESIS
KW  - RISK assessment
KW  - STATISTICS
KW  - ANIMALS
KW  - BIOLOGICAL models
KW  - EXPERIMENTAL design
KW  - TUMORS
N1  - Accession Number: 7392790; Portier, C. 1 El Masri, H. 1; Affiliation:  1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States; Source Info: 1997, Vol. 6 Issue 4, p305; Subject Term: CARCINOGENESIS; Subject Term: RISK assessment; Subject Term: STATISTICS; Subject Term: ANIMALS; Subject Term: BIOLOGICAL models; Subject Term: EXPERIMENTAL design; Subject Term: TUMORS; Number of Pages: 11p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107236991
T1  - Science watch. Mysteries of the heart... including by Epstein SE.
AU  - Dickman S
Y1  - 1997/12//
N1  - Accession Number: 107236991. Language: English. Entry Date: 19980101. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Consumer Health; USA. NLM UID: 9889734. 
KW  - Coronary Disease -- Physiopathology
KW  - Cytomegaloviruses
KW  - Angioplasty, Transluminal, Percutaneous Coronary
KW  - Physiological Theory
KW  - Recurrence
SP  - 202
EP  - 205
JO  - Women's Health Digest
JF  - Women's Health Digest
JA  - WOMENS HEALTH DIGEST
VL  - 3
IS  - 3
PB  - Women's Health Digest
AB  - Of all the thousands of diseases that keep hypochondriacs awake all night, cancer of the heart is not one of them. Unlike bone, skin, brain, liver, blood, kidneys, and bowels, our heart muscle and the coronary blood vessels that embrace it rarely turn cancerous.
SN  - 1078-7674
AD  - National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2008-13558-007
AN  - 2008-13558-007
AU  - Behar, T. N.
AU  - Dugich-Djordjevic, M. M.
AU  - Li, Y-X.
AU  - Ma, W.
AU  - Somogyi, R.
AU  - Wen, X.
AU  - Brown, E.
AU  - Scott, C.
AU  - McKay, R. D. G.
AU  - Barker, J. L.
T1  - Neurotrophins stimulate chemotaxis of embryonic cortical neurons.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1997/12//
VL  - 9
IS  - 12
SP  - 2561
EP  - 2570
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Behar, T. N., LNP/NINDS/NIH, Bldg 36, Rm 2C02, 36 Convent Drive MSC 4066, Bethesda, MD, US, 20892-4066
N1  - Accession Number: 2008-13558-007. PMID: 9517461 Partial author list: First Author & Affiliation: Behar, T. N.; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain Development; Kinases; Neurons; Neurotrophic Factor. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 1997. 
AB  - During mammalian cortical development, neuronal precursors proliferate within ventricular regions then migrate to their target destinations in the cortical plate, where they organize into layers. In the rat, most cortical neuronal migration occurs during the final week of gestation (Bayer et al., 1991; Jacobson, 1991). At this time (E15–E21), reverse transcriptase-polymerase chain reaction demonstrated that cortical homogenates contain mRNA encoding brain derived neurotrophic factor (BDNF) and the catalytic form of its high-affinity receptor, TrkB. lmmunocytochemistry and in situ hybridization of sections revealed that the catalytic TrkB receptors predominantly localize to regions containing migratory cells. Many TrkB+ cells exhibited the classic morphology of migrating neurons, suggesting that TrkB ligands play a role in cortical neuronal migration. We analysed whether TrkB ligands influence the motility of embryonic cortical cells (from E15–E21) using a quantitative in vitro chemotaxis assay. High-affinity TrkB ligands (BDNF and NT4/5) stimulated chemotaxis (directed migration) of embryonic neurons at concentrations ranging from 1 to 100 ng/ml. NT-3, a low-affinity TrkB ligand, only stimulated significant migration at high concentrations (≥100 ng/ml). Peak migration to BDNF was observed at gestational day 18 (E18). BDNF-induced chemotaxis was blocked by either tyrosine kinase inhibitor, K252a, or the Ca2+-chelator, BAPTA-AM, suggesting that BDNF-induces motility via autophosphorylation of TrkB receptor proteins and involves Ca2+-dependent mechanisms. BDNF-stimulation of increased cytosolic Ca2+ was confirmed with optical recordings of E18 cortical cells loaded with Ca2+ indicator dye. Thus, signal transduction through the TrkB receptor complex directs neuronal migration, suggesting that, in vivo, BDNF exerts chemotropic effects that are critical to morphogenesis of the cortex. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurotrophins
KW  - chemotaxis
KW  - embryonic cortical neurons
KW  - mammalian cortical development
KW  - neuronal migration
KW  - 1997
KW  - Brain Development
KW  - Kinases
KW  - Neurons
KW  - Neurotrophic Factor
KW  - Rats
KW  - 1997
DO  - 10.1111/j.1460-9568.1997.tb01685.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13558-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39871-019
AN  - 2015-39871-019
AU  - Liebl, Daniel J.
AU  - Tessarollo, Lino
AU  - Palko, Mary Ellen
AU  - Parada, Luis F.
T1  - Absence of sensory neurons before target innervation in brain- derived neurotrophic factor-, neurotrophin 3-, and trkC-deficient embryonic mice.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/12//
VL  - 17
IS  - 23
SP  - 9113
EP  - 9121
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Parada, Luis F., Developmental Biology Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX, US, 75235-9133
N1  - Accession Number: 2015-39871-019. PMID: 9364058 Partial author list: First Author & Affiliation: Liebl, Daniel J.; Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, TX, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Liebl, Daniel J. Major Descriptor: Mice; Sensory Neurons; Brain Derived Neurotrophic Factor. Minor Descriptor: Expectations; Genes. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 1997. Publication History: Accepted Date: Sep 12, 1997; Revised Date: Sep 5, 1997; First Submitted Date: Apr 4, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Gene-targeting experiments of Trk receptors and neurotrophins has confirmed the expectation that embryonic sensory and sympathetic neurons require neurotrophin function for survival. They have further revealed correlation between a specific neurotrophin requirement and eventual sensory modality. We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes. Our data confirm an unexpectedly high proportion of sensory neuron losses in NT-3 (> 70%), BDNF (> 20%), and TrkC (> 30%) mutants, which encompass populations thought to be NGF-dependent. Direct comparison of TrkC and NT-3 mutants indicates that only a subset of the NT-3-dependent neurons also requires TrkC. The observed losses in our TrkC mutant, which is null for all proteins encoded by the gene, are more severe than those previously reported for the kinase-negative TrkC mutation, implicating additional and important functions for the truncated receptors. Our data further indicate that mature NGF-requiring neurons undergo precocious and transitory requirements for NT-3 and/or BDNF. We suggest that neurotrophins may function in creating early heterogeneity that would enable ganglia to compensate for diverse modality requirements before the period of naturally occurring death. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - BDNF
KW  - NT 3
KW  - Trk
KW  - gene targeting
KW  - neurotrophins
KW  - sensory neurons
KW  - 1997
KW  - Mice
KW  - Sensory Neurons
KW  - Brain Derived Neurotrophic Factor
KW  - Expectations
KW  - Genes
KW  - 1997
U1  - Sponsor: National Institutes of Health, US. Grant: NS33199. Recipients: Liebl, Daniel J.; Parada, Luis F.
U1  - Sponsor: US Department of Health and Human Services, National Cancer Institute, US. Grant: N01-CO-4600. Other Details: Advanced Bioscience Laboratory. Recipients: Tessarollo, Lino; Palko, Mary Ellen; Parada, Luis F.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-39871-019&site=ehost-live&scope=site
UR  - PARADA@UTSW.SWMED.EDU
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-39893-010
AN  - 2015-39893-010
AU  - Maurer, Jennifer A.
AU  - Wray, Susan
T1  - Luteinizing hormone-releasing hormone (LHRH) neurons maintained in hypothalamic slice explant cultures exhibit a rapid LHRH mRNA turnover rate.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1997/12//
VL  - 17
IS  - 24
SP  - 9481
EP  - 9491
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wray, Susan, Cellular and Developmental Neurobiology, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 4D10, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-39893-010. PMID: 9391004 Partial author list: First Author & Affiliation: Maurer, Jennifer A.; Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Maurer, Jennifer A. Major Descriptor: Genes; Luteinizing Hormone; Rats; Immunocytochemistry; mRNA. Minor Descriptor: Gene Expression; Neuropeptides. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 1997. Publication History: Accepted Date: Oct 2, 1997; Revised Date: Sep 9, 1997; First Submitted Date: Jul 2, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - Evidence indicates that neuropeptide gene expression is tightly coupled to biosynthesis and secretion. Moreover, rhythmic gene expression often accompanies rhythmic secretion. Luteinizing hormone-releasing hormone (LHRH) neurosecretion, which regulates gonadal function, is pulsatile, with interpulse intervals of ∼1 hr and pulse decays of < 30 min in rats. As a basis for a rapid fall in peptide secretion, we hypothesize that LHRH mRNA levels rapidly decay. To address this hypothesis, we examined LHRH mRNA turnover in primary postnatal LHRH neurons maintained in long-term hypothalamic/preoptic area slice explant cultures, using in situ hybridization histochemistry (ISHH). Relative LHRH mRNA content per cell was quantitated by single-cell analysis after transcription inhibition with 5,6- dichloro-1-D-ribofuranosyl-benzimidazole (DRB) or actinomycin D. Cultures were maintained in serum-free medium with tetrodotoxin to suppress spontaneous electrical activity and hence assess only intrinsic cellular activity. A plot of LHRH mRNA level per cell versus DRB treatment time showed a rapid initial decay of LHRH mRNA (t1/2, 5–13 min), followed by a slower decay rate (t1/2, 329–344 hr). LHRH cell number after drug treatment as determined by immunocytochemistry did not change. Comparison of mammalian LHRH mRNA 39-untranslated regions showed two conserved regions. These data indicate that, in primary LHRH neurons, LHRH mRNA has an intrinsically high rate of turnover and a mRNA stabilization component. Foremost, decay of LHRH mRNA, the fastest reported for a neuropeptide to date, corresponds to the decay of LHRH peptide pulses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - DRB
KW  - gene expression
KW  - GnRH
KW  - mRNA stability
KW  - organotypic
KW  - preoptic area
KW  - 1997
KW  - Genes
KW  - Luteinizing Hormone
KW  - Rats
KW  - Immunocytochemistry
KW  - mRNA
KW  - Gene Expression
KW  - Neuropeptides
KW  - 1997
U1  - Sponsor: National Institutes of Health, National Institute of General Medical Sciences, US. Recipients: Maurer, Jennifer A.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Gadbut, Albert P.
AU  - Leeying Wu
AU  - Dongjiang Tang
AU  - Papageorge, Alexander
AU  - Watson, John A.
AU  - Galper, Jonas B.
T1  - Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for Ras in regulating the expression of muscarinic receptors and G proteins.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/12/15/
VL  - 16
IS  - 24
M3  - Article
SP  - 7250
EP  - 7260
SN  - 02614189
AB  - We propose a novel mechanism for the regulation of the processing of Ras and demonstrate a new function for Ras in regulating the expression of cardiac auto- nomic receptors and their associated G proteins. We have demonstrated previously that induction of endogenous cholesterol synthesis in cultured cardiac myocytes resulted in a coordinated increase in expression of muscarinic receptors, the G protein α-subunit, G-αi2, and the inward rectifying K+ channel, GIRK1. These changes in gene expression were associated with a marked increase in the response of heart cells to parasympathetic stimulation. In this study, we demonstrate that the induction of the cholesterol metabolic pathway regulates Ras processing and that Ras regulates expression of G-αi2. We show that in primary cultured myocytes most of the RAS is localized to the cytoplasm in an unfarnesylated form. Induction of the cholesterol metabolic pathway results in increased farnesylation and membrane association of RAS. Studies of Ras mutants expressed in cultured heart cells demonstrate that activation of Ras by induction of the cholesterol metabolic pathway results in increased expression of G-α i2 mRNA. Hence farnesylation of Ras is a regulatable process that plays a novel role in the control of second messenger pathways. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE expression
KW  - MUSCARINIC receptors
KW  - G proteins
KW  - MEMBRANE proteins
KW  - GENETIC regulation
KW  - GENETICS
KW  - cholesterol
KW  - farnesylation
KW  - g protein
KW  - heart cells
KW  - ras
N1  - Accession Number: 13005934; Gadbut, Albert P. 1 Leeying Wu 1 Dongjiang Tang 1 Papageorge, Alexander 2 Watson, John A. 3 Galper, Jonas B. 1; Affiliation:  1: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA  2: Laboratory of Cellular Oncology, National Institutes of Health, Bethesda, MD  3: Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA; Source Info: 12/15/97, Vol. 16 Issue 24, p7250; Subject Term: GENE expression; Subject Term: MUSCARINIC receptors; Subject Term: G proteins; Subject Term: MEMBRANE proteins; Subject Term: GENETIC regulation; Subject Term: GENETICS; Author-Supplied Keyword: cholesterol; Author-Supplied Keyword: farnesylation; Author-Supplied Keyword: g protein; Author-Supplied Keyword: heart cells; Author-Supplied Keyword: ras; Number of Pages: 11p; Document Type: Article
L3  - 10.1093/emboj/16.24.7250
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fazioli, Francesca
AU  - Resnati, Massimo
AU  - Sidenius, Nicolai
AU  - Higashimoto, Yuichiro
AU  - Appella, Ettore
AU  - Blasi, Francesco
T1  - A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/12/15/
VL  - 16
IS  - 24
M3  - Article
SP  - 7279
EP  - 7286
SN  - 02614189
AB  - The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR/CD87) in cell migration and invasion is well substantiated. Recently, uPA has been shown to be essential in cell migration, since uPA­/­ mice are greatly impaired in inflammatory cell recruitment. We have shown previously that the uPA-induced chemotaxis requires interaction with and modification of uPAR/CD87, which is the true chemoattracting molecule acting through an unidentified cell surface component which mediates this cell surface chemokine activity. By expressing and testing several uPAR/CD87 variants, we have located and functionally characterized a potent uPAR/CD87 epitope that mimics the effects of the uPA­uPAR interaction. The chemotactic activity lies in the region linking domains 1 and 2, the only protease-sensitive region of uPAR/CD87, efficiently cleaved by uPA at physiological concentrations. Synthetic peptides carrying this epitope promote chemotaxis and activate p56/p59hck tyrosine kinase. Both chemotaxis and kinase activation are pertussis toxin sensitive, involving a Gi/o protein in the pathway. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - UROKINASE
KW  - PLASMINOGEN activators
KW  - CELL migration
KW  - CHEMOKINES
KW  - PEPTIDES
KW  - CYTOLOGY
KW  - chemotaxis
KW  - g protein
KW  - pertussis toxin
KW  - receptor
KW  - urokinase-type plasminogen activator
N1  - Accession Number: 13005931; Fazioli, Francesca 1,2 Resnati, Massimo 1,2 Sidenius, Nicolai 1,2 Higashimoto, Yuichiro 3 Appella, Ettore 3 Blasi, Francesco 1,2; Email Address: blasif@dibit.hsr.it; Affiliation:  1: Department of Biology and Biotechnology (DIBIT), San Raffaele Scientific Institute, Via Olgettina, Milan  2: Department of Genetics and Microbial Biology, University of Milan, Via Celoria 26, Milan, Italy  3: Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, USA; Source Info: 12/15/97, Vol. 16 Issue 24, p7279; Subject Term: UROKINASE; Subject Term: PLASMINOGEN activators; Subject Term: CELL migration; Subject Term: CHEMOKINES; Subject Term: PEPTIDES; Subject Term: CYTOLOGY; Author-Supplied Keyword: chemotaxis; Author-Supplied Keyword: g protein; Author-Supplied Keyword: pertussis toxin; Author-Supplied Keyword: receptor; Author-Supplied Keyword: urokinase-type plasminogen activator; Number of Pages: 8p; Document Type: Article
L3  - 10.1093/emboj/16.24.7279
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shui-Qing Wei
AU  - Mizuuchi, Kiyoshi
AU  - Craigie, Robert
T1  - A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/12/15/
VL  - 16
IS  - 24
M3  - Article
SP  - 7511
EP  - 7520
SN  - 02614189
AB  - We have probed the nucleoprotein organization of Moloney murine leukemia virus (MLV) pre-integration complexes using a novel footprinting technique that utilizes a simplified in vitro phage Mu transposition system. We find that several hundred base pairs at each end of the viral DNA are organized in a large nucleoprotein complex, which we call the intasome. This structure is not formed when pre-integration complexes are made by infecting cells with integrase-minus virus, demonstrating a requirement for integrase. In contrast, footprinting of internal regions of the viral DNA did not reveal significant differences between pre-integration complexes with and without integrase. Treatment with high salt disrupts the intasome in parallel with loss of intermolecular integration activity. We show that a cellular factor is required for reconstitution of the intasome. Finally, we demonstrate that DNA­protein interactions involving extensive regions at the ends of the viral DNA are functionally important for retroviral DNA integration activity. Current in vitro integration systems utilizing purified integrase lack the full fidelity of the in vivo reaction. Our results indicate that both host factors and long viral DNA substrates may be required to reconstitute an in vitro system with all the hallmarks of DNA integration in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOUSE leukemia viruses
KW  - RETROVIRUSES
KW  - NUCLEOPROTEINS
KW  - TRANSLOCATION (Genetics)
KW  - GENETICS
KW  - MOLECULAR biology
KW  - dna transposition
KW  - footprinting
KW  - pcr
KW  - pre-integration complexes
KW  - retrovirus
N1  - Accession Number: 13005909; Shui-Qing Wei 1 Mizuuchi, Kiyoshi 1 Craigie, Robert 1; Email Address: bobc@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: 12/15/97, Vol. 16 Issue 24, p7511; Subject Term: MOUSE leukemia viruses; Subject Term: RETROVIRUSES; Subject Term: NUCLEOPROTEINS; Subject Term: TRANSLOCATION (Genetics); Subject Term: GENETICS; Subject Term: MOLECULAR biology; Author-Supplied Keyword: dna transposition; Author-Supplied Keyword: footprinting; Author-Supplied Keyword: pcr; Author-Supplied Keyword: pre-integration complexes; Author-Supplied Keyword: retrovirus; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/16.24.7511
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13005909&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schumacher, Silke
AU  - Clubb, Robert T.
AU  - Cai, Mengli
AU  - Mizuuchi, Kiyoshi
AU  - Clore, G. Marius
AU  - Gronenborn, Angela M.
T1  - Solution structure of the Mu end DNA-binding Iß subdomain of phage Mu transposase: modular DNA recognition by two tethered domains.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1997/12/15/
VL  - 16
IS  - 24
M3  - Article
SP  - 7532
EP  - 7541
SN  - 02614189
AB  - The phage Mu transposase (MuA) binds to the ends of the Mu genome during the assembly of higher order nucleoprotein complexes. We investigate the structure and function of the MuA end-binding domain (Iβγ). The three-dimensional solution structure of the Iβ subdomain (residues 77&ndash174) has been determined using multidimensional NMR spectroscopy. It comprises five α-helices, including a helix­turn­helix (HTH) DNA-binding motif formed by helices 3 and 4, and can be subdivided into two interacting structural elements. The structure has an elongated disc-like appearance from which protrudes the recognition helix of the HTH motif. The topology of helices 2&ndash4 is very similar to that of helices 1&ndash3 of the previously determined solution structure of the MuA Iγ subdomain and to that of the homeodomain family of HTH DNA-binding proteins. We show that each of the two subdomains binds to one half of the 22 bp recognition sequence, Iβ to the more conserved Mu end distal half (β subsite) and Iγ to the Mu end proximal half (γ subsite) of the consensus Mu end-binding site. The complete Iβγ domain binds the recognition sequence with a 100- to 1000-fold higher affinity than the two subdomains independently, indicating a cooperative effect. Our results show that the Mu end DNA-binding domain of MuA has a modular organization, with each module acting on a specific part of the 22 bp binding site. Based on the present binding data and the structures of the Iβ and Iγ subdomains, a model for the interaction of the complete Iβγ domain with DNA is proposed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA-protein interactions
KW  - DNA-binding proteins
KW  - TRANSLOCATION (Genetics)
KW  - GENETICS
KW  - MOLECULAR biology
KW  - BINDING sites (Biochemistry)
KW  - BIOCHEMISTRY
KW  - domain
KW  - i&beta
KW  - mua transposase
KW  - nmr
KW  - protein­dna interaction
KW  - solution structure
N1  - Accession Number: 13005907; Schumacher, Silke 1 Clubb, Robert T. 1,2 Cai, Mengli 1 Mizuuchi, Kiyoshi 3 Clore, G. Marius 1; Email Address: clore@vger.niddk.nih.gov Gronenborn, Angela M. 1; Email Address: gronenborn@vger.niddk.nih.gov; Affiliation:  1: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA  2: Department of Chemistry and Biochemistry, University of California, Los Angeles at Los Angeles, CA, USA  3: Laboratory of Molecular Biology, National Institute of Health, Bethesda, MD, USA; Source Info: 12/15/97, Vol. 16 Issue 24, p7532; Subject Term: DNA-protein interactions; Subject Term: DNA-binding proteins; Subject Term: TRANSLOCATION (Genetics); Subject Term: GENETICS; Subject Term: MOLECULAR biology; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: domain; Author-Supplied Keyword: i&beta; Author-Supplied Keyword: mua transposase; Author-Supplied Keyword: nmr; Author-Supplied Keyword: protein­dna interaction; Author-Supplied Keyword: solution structure; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/16.24.7532
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - PATTERSON, BLOSSOM H.
AU  - KREHS-SMITH, SUSAN M.
AU  - SUBAR, AMY F.
AU  - POPKIN, BARRY M.
AU  - SIEGA-RIZ, ANNA MARIA
AU  - HAINES, PAMELA S.
AU  - KUMANYIKA, SHIRIKI
T1  - Correction and Revision of Conclusions--Dietary Trends in the United States.
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1997/12/18/
VL  - 337
IS  - 25
M3  - Article
SP  - 1846
EP  - 1848
SN  - 00284793
N1  - Accession Number: 88411733; PATTERSON, BLOSSOM H. 1 KREHS-SMITH, SUSAN M. 1 SUBAR, AMY F. 1 POPKIN, BARRY M. 2 SIEGA-RIZ, ANNA MARIA 2 HAINES, PAMELA S. 2 KUMANYIKA, SHIRIKI 3; Affiliation:  1: National Cancer Institute Bethesda, MD 20892-7354  2: University of North Carolina Chapel Hill, NC 27514  3: University of Illinois at Chicago, Chicago, It 60612-7256; Source Info: 12/18/97, Vol. 337 Issue 25, p1846; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - Gen
ID  - 9999-16672-000
AN  - 9999-16672-000
AU  - Davey, Graham C. L.
AU  - McDonald, Angus S.
AU  - Hirisave, Uma
AU  - Prabhu, G. G.
AU  - Iwawaki, Saburo
AU  - Jim, Ching Im
AU  - Merckelbach, Harald
AU  - de Jong, Peter J.
AU  - Leung, Patrick W. L.
AU  - Reimann, Bradley C.
T1  - Animal Fear Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1998///
AD  - Davey, Graham C. L., University of Sussex, Psychology Group, School of Cognitive and Computing Sciences, Brighton, United Kingdom, BN1 9QH
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No
N1  - Accession Number: 9999-16672-000. Partial author list: First Author & Affiliation: Davey, Graham C. L.; University of Sussex, Psychology Group, School of Cognitive and Computing Sciences, Brighton, United Kingdom. Release Date: 20130408. Test Format: All subjects are given a one page questionnaire listing 51 animals which asks them to rate fear to each animal on a simple four-point scale, where 0 =not frightened at all, 1= mild dislike but not anxious, 2 =makes me feel anxious and nervous, 3= makes me feel very frightened, avoid at all costs.. Language: Chinese; Dutch; English; Hindi; Japanese. Constructs: Animal Fear; Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Animal Fear Questionnaire is to measure participants fear of animals in multiple cultures.
AB  - Description: The Animal Fear Questionnaire (Davey et al., 1998) was developed to measure participants fear of animals in multiple cultures. This questionnaire was designed for a cross-cultural study describing the results of a survey of animal fears collected from college students in seven countries: Japan, UK, USA, The Netherlands, India, Korea, and Hong Kong. All subjects were given a one page questionnaire listing 51 animals which asked them to rate fear to each animal on a simple four-point scale, where 0 =not frightened at all, 1= mild dislike but not anxious, 2 =makes me feel anxious and nervous, 3= makes me feel very frightened, avoid at all costs. Each questionnaire was translated into the native language for each cohort, and in the case of some countries a small number of animals listed in the questionnaire were changed because they were animals relatively unfamiliar to subjects in that country. The fifty one animals included in the questionnaire were selected from those included in animal phobia studies using a UK subject population conducted by Ware et al. (1994), Davey (1994b) and Matchett and Davey (1991) to provide a representative sample of animals characterising fierce animals (e.g. lion, tiger, crocodile), disgust-relevant animals (e.g. cockroach, maggot, rat) or fear-irrelevant animals (e.g. rabbit, sheep, chicken).
KW  - Animal Fear Questionnaire
KW  - Cross-Cultural Differences
KW  - Factor Analysis
KW  - Internal Consistency
KW  - Coherent Fear-Irrelevant Subscale
KW  - Fear-Relevant (Fierce) Subscale
KW  - Disgust-Relevant Subscale
U5  - Animal Fear Questionnaire [Test Development]A cross-cultural study of animal fears. (AN: 1998-10076-007 from PsycINFO) Davey, Graham C. L.; McDonald, Angus S.; Hirisave, Uma; Prabhu, G. G.; Iwawaki, Saburo; Jim, Ching Im; Merckelbach, Harald; de Jong, Peter J.; Leung, Patrick W. L.; Reimann, Bradley C.; Jul-Aug, 1998. Source: Behaviour Research and Therapy. 36(7-8), Elsevier Science, Netherlands; Jul-Aug, 1998; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Locations: United Kingdom, United States, India, Netherlands, Korea, Hong Kong, and Japan; Sample: College Students Keywords: Animal Fear Questionnaire; Cross-Cultural Differences; Factor Analysis; Internal Consistency; Coherent Fear-Irrelevant Subscale; Fear-Relevant (Fierce) Subscale; Disgust-Relevant Subscale; Subjects: Animal Aggressive Behavior; Animals; Cross Cultural Differences; Disgust; Factor Structure; Fear;
DO  - 10.1037/t16672-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-16672-000&site=ehost-live&scope=site
UR  - grahamda@cogs.susx.ac.uk
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-19624-000
AN  - 9999-19624-000
AU  - Chandra, Prabha S.
AU  - Chaturvedi, Santosh K.
AU  - Kumar, Anil
AU  - Kumar, Sateesh
AU  - Subbakrishna, D. K.
AU  - Channabasavanna, S. M.
AU  - Anantha, N.
T1  - Awareness of Cancer Diagnosis Interview
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1998///
AD  - Chandra, Prabha S.
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-19624-000. Partial author list: First Author & Affiliation: Chandra, Prabha S.; National Institute of Mental Health and Neurosciences, Department of Psychiatry, Bangalore, India. Release Date: 20130408. Correction Date: 20151109. Instrument Type: Interview Schedule/Guide. Test Location: Text, Page 258. Test Format: Respondents answer 5 open-ended questions.. Language: English. Constructs: Cancer Awareness; Classification: Physical Health/Illness Related Assessment (7300). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300). 
N2  - Administration Method: Interview
AB  - Purpose: The Awareness of Cancer Diagnosis Interview was designed to assess patients' awareness of their cancer diagnosis.
AB  - Description: The Awareness of Cancer Diagnosis Interview (Chandra et al., 1998) was developed in the context of a study investigating awareness of disease among cancer patients, and its relationship to psychiatric morbidity in patients newly admitted to a large oncology hospital. Patients respond to 5 open-ended questions regarding the nature of their illness and its treatment, and awareness is assessed by patients’ ability to acknowledge their illness and use the terms 'cancer' or 'malignancy.' A similar set of questions can also be administered to patients’ relatives. No information on the psychometric properties of this measure is provided in the development article. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Awareness of Cancer Diagnosis Interview
KW  - Test Development
U5  - Awareness of Cancer Diagnosis Interview [Test Development]Awareness of diagnosis and psychiatric morbidity among cancer patients—a study from South India. (AN: 1998-10693-006 from PsycINFO) Chandra, Prabha S.; Chaturvedi, Santosh K.; Kumar, Anil; Kumar, Sateesh; Subbakrishna, D. K.; Channabasavanna, S. M.; Anantha, N.; Sep, 1998. Source: Journal of Psychosomatic Research. 45(3), Elsevier Science, Netherlands; Sep, 1998; Administration: Interview Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Inpatient; Location: India; Sample: Cancer Patients Newly Admitted to an Oncology Center and Their Relatives Keywords: Awareness of Cancer Diagnosis Interview; Test Development; Subjects: Awareness; Diagnosis; Interview Schedules; Neoplasms; Test Construction;
DO  - 10.1037/t19624-000
L3  - Partial; Full text; 999919624_partial_001.pdf
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UR  - chandra@nimhans.kar.nic.in
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
AU  - Hashimoto, Kenji
AU  - Minabe, Yoshio
AU  - Iyo, Masaomi
AU  - Hashimoto, K
AU  - Minabe, Y
AU  - Iyo, M
T1  - Expression of brain-derived neurotrophic factor (BDNF) mRNA in rat retrosplenial cortex following administration of phencyclidine.
JO  - Addiction Biology
JF  - Addiction Biology
Y1  - 1998/01//
VL  - 3
IS  - 1
M3  - journal article
SP  - 79
EP  - 83
PB  - Wiley-Blackwell
SN  - 13556215
AB  - The non-competitive NMDA receptor antagonists such as phencyclidine (PCP) cause neurotoxicity in the retrosplenial cortex of rat brain. However, the precise mechanism(s) underlying the neurotoxicity of NMDA receptor antagonists is currently unclear. Using an in situ hybridization technique, we studied the effects of PCP on expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain. No expression of BDNA mRNA was observed in the retrosplenial cortex of rats treated with vehicle, although a high basal level of BDNF mRNA was detected in the hippocampus of control rats. Administration of PCP (12.5, 25 or 50 mg/kg, i.p., 6 hours) caused marked induction of BDNF mRNA in the retrosplenial cortex, in a dosedependent manner. These results suggest that the expression of BDNF mRNA may occur as a trophic response to the neurotoxicity of NMDA receptor antagonists such as PCP. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Addiction Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHENCYCLIDINE
KW  - ANIMAL experimentation
N1  - Accession Number: 222736; Hashimoto, Kenji Minabe, Yoshio Iyo, Masaomi Hashimoto, K 1 Minabe, Y 1 Iyo, M 1; Affiliation:  1: Division of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, TokyoDivision of Drug Dependence and Psychotropic Drug Clinical Research, National Institute of Mental Health, NCNP, Ichikawa, Chiba, Japan; Source Info: Jan1998, Vol. 3 Issue 1, p79; Subject Term: PHENCYCLIDINE; Subject Term: ANIMAL experimentation; Number of Pages: 5p; Illustrations: 6 Black and White Photographs; Document Type: journal article; Full Text Word Count: 1855
L3  - 10.1080/13556219872371
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=222736&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - De La Rosa, Mario R.
T1  - Prevalence and Consequences of Alcohol, Cigarette, and Drug Use Among Hispanics.
JO  - Alcoholism Treatment Quarterly
JF  - Alcoholism Treatment Quarterly
Y1  - 1998/01//
VL  - 16
IS  - 1/2
M3  - Article
SP  - 21
EP  - 54
SN  - 07347324
AB  - This paper presents an overview of the prevalence of alcohol, heavy alcohol, cigarette, cocaine, and marijuana use in the Hispanic population living in the mainland United States and their attitudes and perceptions regarding the availability in alcohol and other drugs in their neighborhood. In addition, this paper will describe the major consequences of drug use and make recommendations for future research. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Alcoholism Treatment Quarterly is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOL
KW  - COCAINE
KW  - MARIJUANA
KW  - SUBSTANCE abuse
KW  - HISPANIC Americans
KW  - SMOKING
KW  - CIGARETTE smokers
KW  - RESEARCH
KW  - UNITED States
N1  - Accession Number: 424722; De La Rosa, Mario R. 1; Affiliation:  1: Health Science Administrator, National Institute on Drug Abuse, 5600 Fishers Lane, Room 9A-42, Rockville, MD 20857; Source Info: 1998, Vol. 16 Issue 1/2, p21; Subject Term: ALCOHOL; Subject Term: COCAINE; Subject Term: MARIJUANA; Subject Term: SUBSTANCE abuse; Subject Term: HISPANIC Americans; Subject Term: SMOKING; Subject Term: CIGARETTE smokers; Subject Term: RESEARCH; Subject Term: UNITED States; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; Number of Pages: 34p; Illustrations: 12 Charts, 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107241761
T1  - Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: a controlled dietary study.
AU  - Forman MR
AU  - Johnson EJ
AU  - Lanza E
AU  - Graubard BI
AU  - Beecher GR
AU  - Muesing R
Y1  - 1998/01//
N1  - Accession Number: 107241761. Language: English. Entry Date: 19980201. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Menstrual Cycle
KW  - Carotenoids
KW  - Lipoproteins
KW  - Diet
KW  - Carotenoids -- Analysis
KW  - Lipoproteins -- Analysis
KW  - Blood -- Analysis
KW  - Luteinizing Hormone -- Analysis
KW  - Progesterone -- Analysis
KW  - Analysis of Variance
KW  - Adult
KW  - Female
KW  - Human
SP  - 81
EP  - 87
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 67
IS  - 1
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Because premenopausal women experience cyclic fluctuations of plasma carotenoids and their lipoprotein carriers, it is hypothesized that carotenoid concentrations in lipoprotein fractions fluctuate by phase of the menstrual cycle. Nine women ate a standard set of carotenoid-rich foods daily for two cycles under isoenergetic conditions. In the second cycle, hormones and carotenoids in lipoprotein fractions were measured in the early and late follicular and luteal phases. alpha-Carotene concentrations in the LDL fraction were lower in the early than in the late follicular phase (P = 0.03) on the basis of regression analysis. beta-carotene concentrations in the LDL fraction and the HDL2 subfraction were higher in the late follicular than in the luteal phase (P = 0.02 and P = 0.04, respectively). Lutein/zeaxanthin concentrations in the LDL and HDL fractions were higher in the late follicular than in the luteal phase (P = 0.03 and P = 0.02, respectively). In each phase, 80% of alpha-carotene, 82% of beta-carotene, 85% of lycopene, and 64% of lutein/zeaxanthin were distributed in the LDL fraction. Among the hydrocarbon cartenoids, 18% of alpha-carotene and of beta-carotene and 13% of lycopene were distributed in the HDL fraction, with slightly more in the HDL2 than in the HDL3 subfraction. In contrast 34% of lutein/zeaxanthin was distributed in the HDL fraction with more concentrated in the HDL3 than in the HDL2 subfraction. Less than 4% of any carotenoid was found in the VLDL + IDL (intermediate-density-lipoprotein) fractions. Thus, the hydrocarbon carotenoids were highly concentrated in the LDL fraction and xanthophyll was more evently distributed in the LDL and HDL fractions. The cyclic fluctuations of these carotenoids in lipoprotein fractions add another dimension to the understanding of their transport and physiologic function. Copyright (c) 1998 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD. E-mail: mf63p@nih.gov
U2  - PMID: 9440379.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107241761&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Weed, Douglas L.
T1  - Beyond black box epidemiology.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/01//
VL  - 88
IS  - 1
M3  - Editorial
SP  - 12
EP  - 14
PB  - American Public Health Association
SN  - 00900036
AB  - The author describes the historical threads of the discussion regarding black box epidemiology and its potential to unite epidemiology in all its disciplinary complexity. He believes that even with the incomplete presentation and practice of systems theory, epidemiologists should embrace rather than denigrate the idea of black boxes. He recommends the need to explicate and to agree on the basic values of the discipline and for epidemiologists to go beyond the pejorative connotation of black box thinking by embracing a systems theory approach.
KW  - EPIDEMIOLOGY
KW  - PUBLIC health
KW  - EPIDEMIOLOGISTS
KW  - SYSTEMS theory
KW  - MEDICAL scientists
KW  - PUBLIC health personnel
N1  - Accession Number: 450478; Weed, Douglas L. 1; Affiliation:  1: Preventive Oncology Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.; Source Info: Jan1998, Vol. 88 Issue 1, p12; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health; Subject Term: EPIDEMIOLOGISTS; Subject Term: SYSTEMS theory; Subject Term: MEDICAL scientists; Subject Term: PUBLIC health personnel; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 2408
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - NEWS
AU  - Rockhill, Beverly
AU  - Newman, Beth
AU  - Weinberg, Clarice
T1  - Use and misuse of population attributable fractions.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/01//
VL  - 88
IS  - 1
M3  - Editorial
SP  - 15
EP  - 19
PB  - American Public Health Association
SN  - 00900036
AB  - The article considers computational and conceptual issues relevant to population attributable fraction estimation that are infrequently discussed elsewhere aimed to guide policymakers in planning public health interventions. It also presents illustrations from the breast cancer literature in order to summarize the state of etiologic knowledge about the disease.
KW  - EPIDEMIOLOGY
KW  - PUBLIC health research
KW  - MEDICAL model
KW  - BREAST cancer
N1  - Accession Number: 450479; Rockhill, Beverly 1 Newman, Beth 2 Weinberg, Clarice 3; Affiliation:  1: Channing Laboratory and Harvard School of Public Health, Boston, Mass.  2: Department of Epidemiology, University of North Carolina, Chapel Hill  3: National Institute of Environmental Health Sciences, Research Triangle Park, NC; Source Info: Jan1998, Vol. 88 Issue 1, p15; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health research; Subject Term: MEDICAL model; Subject Term: BREAST cancer; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Editorial; Full Text Word Count: 3631
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thompson, Beti
AU  - Rich, Lauren E.
AU  - Lynn, William R.
AU  - Shields, Rusty
AU  - Corle, Donald K.
T1  - A voluntary smokers' registry: Characteristics of joiners and non-joiners in the Community Intervention Trial for Smoking Cessation (COMMIT).
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/01//
VL  - 88
IS  - 1
M3  - Article
SP  - 100
EP  - 103
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This paper examines differences between joiners and nonjoiners of a voluntary smokers' registry. Methods. A baseline prevalence survey was used to identify characteristics of smokers who joined or did not join a smokers' registry. Results. Communities varied significantly in registry enrollment rates. Heavy-smoking joiners expressed more desire to quit, were more likely to live with nonsmokers, and were older than nonjoiners. Light-to-moderate joiners smoked more, were more addicted to cigarettes, and expressed more desire to quit than nonjoiners. Conclusions. Few baseline characteristics differentiated joiners from nonjoiners. Nonjoiners were significantly more likely to achieve cessation than joiners. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SMOKING cessation
KW  - HEALTH surveys
KW  - CIGARETTE smokers
KW  - COMMUNITY health services
KW  - PUBLIC health
N1  - Accession Number: 450495; Thompson, Beti 1 Rich, Lauren E. 2 Lynn, William R. 3 Shields, Rusty 2 Corle, Donald K. 4; Affiliation:  1: Fred Hutchinson Cancer Research Center, Seattle, Wash.  2: Information Management Services Inc, Silver Spring, Md.  3: Public Health Applications Research Branch, National Cancer Institute, Bethesda, Md.  4: Biometry Branch, National Cancer Institute, Bethesda, Md.; Source Info: Jan1998, Vol. 88 Issue 1, p100; Subject Term: SMOKING cessation; Subject Term: HEALTH surveys; Subject Term: CIGARETTE smokers; Subject Term: COMMUNITY health services; Subject Term: PUBLIC health; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3061
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weed, Douglas L.
T1  - Preventing scientific misconduct.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/01//
VL  - 88
IS  - 1
M3  - Article
SP  - 125
EP  - 129
PB  - American Public Health Association
SN  - 00900036
AB  - The article aims to develop scientific misconduct based on models familiar to public health professionals. It discusses some problems that emerge from such an analysis and proposes tentative solutions to those problems. Scientific misconduct was defined as fabrication, falsification, plagiarism, or any other serious deviation from accepted scientific practices in proposing, conducting or reporting research. The article also discusses the role of moral theory in ethics education that may be necessary in any account of the ethics of scientific misconduct.
KW  - PUBLIC health laws
KW  - MEDICAL ethics
KW  - MEDICAL research
KW  - PLAGIARISM
KW  - PUBLIC health personnel -- Malpractice
KW  - PUBLIC health research
N1  - Accession Number: 450501; Weed, Douglas L. 1,2; Email Address: dw102:@nih.gov; Affiliation:  1: Preventive Oncology Branch, National Cancer Institute, Bethesda, Md.  2: Kennedy Institute of Ethics, Georgetown University, Washington, DC; Source Info: Jan1998, Vol. 88 Issue 1, p125; Subject Term: PUBLIC health laws; Subject Term: MEDICAL ethics; Subject Term: MEDICAL research; Subject Term: PLAGIARISM; Subject Term: PUBLIC health personnel -- Malpractice; Subject Term: PUBLIC health research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 4233
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107277656
T1  - Health law and ethics. Preventing scientific misconduct.
AU  - Weed DL
Y1  - 1998/01//
N1  - Accession Number: 107277656. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074. 
KW  - Scientific Misconduct
SP  - 125
EP  - 129
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 88
IS  - 1
CY  - Washington, District of Columbia
PB  - American Public Health Association
SN  - 0090-0036
AD  - Preventive Oncology Branch, National Cancer Institute, EPS T-41, 6130 Executive Blvd MSC 7105, Bethesda, MD 20892. E-mail: dw102:@.nih.gov
U2  - PMID: 9584019.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107264470
T1  - Effects of withdrawal of bracing in matched pairs of children with osteogenesis imperfecta.
AU  - Gerber LH
AU  - Binder H
AU  - Berry R
AU  - Siegel KL
AU  - Kim H
AU  - Weintrob J
AU  - Lee YJ
AU  - Mizell S
AU  - Marini J
Y1  - 1998/01//1998 Jan
N1  - Accession Number: 107264470. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; pictorial; research; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985158R. 
KW  - Osteogenesis Imperfecta -- Rehabilitation
KW  - Orthoses
KW  - Functional Status -- In Infancy and Childhood
KW  - Gait -- In Infancy and Childhood
KW  - Clinical Trials
KW  - Crossover Design
KW  - Prospective Studies
KW  - Fractures -- Etiology -- In Infancy and Childhood
KW  - Severity of Illness
KW  - Child, Preschool
KW  - Child
KW  - Female
KW  - Male
KW  - Descriptive Statistics
KW  - Wilcoxon Rank Sum Test
KW  - Gait Analysis
KW  - Human
SP  - 46
EP  - 51
JO  - Archives of Physical Medicine & Rehabilitation
JF  - Archives of Physical Medicine & Rehabilitation
JA  - ARCH PHYS MED REHABIL
VL  - 79
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To evaluate the effects of withdrawal of long-leg braces (hip-knee-ankle-foot orthoses [HKAFO]) on activity and ambulation in children with osteogenesis imperfecta. DESIGN: A prospective, randomized cross-over trial, that describes the effects of withdrawing HKAFO. PATIENTS: Ten children who were ambulatory with the assistance of braces. All had type III or IV osteogenesis imperfecta. Children were paired for age and clinical severity. Strength testing, fractures, and independence in daily activity were monitored at 4-month intervals for 32 months (16 months each of braced and unbraced periods). Gait was analyzed during braced and unbraced conditions. RESULTS: Muscle strength declined .35 grade during unbraced and .1 grade during braced intervals. Children spent more time in upright activity during braced intervals than during unbraced intervals (p = .17). Children were more independent in daily activities during braced than during unbraced periods (p = .14). Seventeen fractures of lower extremities occurred during all the unbraced periods, and 8 occurred during the braced intervals (p = .08); the fracture rate was higher during unbraced intervals. (p = .06) Bracing was associated with increased hip flexion and stride length and decreased transverse plane pelvic rotation. CONCLUSION: Withdrawal of HKAFO in children with osteogenesis imperfecta who had achieved upright activity was not associated with significant decrease in muscle strength or independence, but there was an associated increase in fracture rate that nearly reached significance. This is a US government work. There are no restrictions on its use.
SN  - 0003-9993
AD  - Chief, Dept of Rehabilitation Medicine, National Institutes of Health, 10 Center Dr, MSC 1604, Bethesda, MD 20892-1604
U2  - PMID: 9440417.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - SHIH, JOANNA H
T1  - A goodness-of-fit test for association in a bivariate survival model.
JO  - Biometrika
JF  - Biometrika
Y1  - 1998/01//
VL  - 85
IS  - 1
M3  - Article
SP  - 189
EP  - 200
SN  - 00063444
AB  - We propose a simple test of constant conditional hazard ratio in the Clayton model (1978) by comparing the unweighted and weighted concordance estimators of the association parameter. If the Clayton model holds, the difference of these two estimates converges to zero. The proposed test is consistent against alternatives under which the two concordance estimators converge to different values. We derive an explicit formula for the asymptotic variance and derive the asymptotic distribution of the test statistic under the Clayton model. Then we extend the test statistic to incorporate censoring. The proposed test is expected to perform well for a general class of alternatives with monotone conditional hazard ratio. We examine the finite sample properties of the test statistic through simulations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONCORDANCES (Topology)
KW  - ESTIMATES
KW  - STOCHASTIC convergence
KW  - ZERO (The number)
KW  - VARIANCES
KW  - Clayton model
KW  - Concordance
KW  - Conditional hazard ratio
KW  - Frailty
N1  - Accession Number: 80102966; SHIH, JOANNA H 1; Affiliation:  1: National Heart, Lung, and Blood Institute, Office of Biostatistics Research, Two Rockledge Centre Room 8217, 6701 Rockledge Drive, Bethesda, Maryland 20892-7938, U.S.A. jshih@helix.nih.gov; Source Info: 1998, Vol. 85 Issue 1, p189; Subject Term: CONCORDANCES (Topology); Subject Term: ESTIMATES; Subject Term: STOCHASTIC convergence; Subject Term: ZERO (The number); Subject Term: VARIANCES; Author-Supplied Keyword: Clayton model; Author-Supplied Keyword: Concordance; Author-Supplied Keyword: Conditional hazard ratio; Author-Supplied Keyword: Frailty; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107251997
T1  - Automated methods in urinalysis.
AU  - King C
Y1  - 1998/01//1998 Jan-Feb
N1  - Accession Number: 107251997. Language: English. Entry Date: 19980401. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; pictorial. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8806547. 
KW  - Urinalysis
KW  - Automation
KW  - Microscopy
KW  - Reagent Kits, Diagnostic
KW  - Education, Continuing (Credit)
SP  - 44
EP  - 55
JO  - Clinical Laboratory Science
JF  - Clinical Laboratory Science
JA  - CLIN LAB SCI
VL  - 11
IS  - 1
CY  - Tysons Corner, Virginia
PB  - American Society for Clinical Laboratory Science
AB  - Automation has been an integral part of clinical laboratory testing for many years. In most moderate, or large laboratory settings, it is common to have a piece of equipment available to automate at least some, if not all portions of the urinalysis (UA). Examples range from the simple hand-held refractometer for the measurement of specific gravity, to a very sophisticated floor model instrument that performs the entire assay.
SN  - 0894-959X
AD  - Warren G Magneson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1508
U2  - PMID: 10177213.
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DB  - rzh
ER  - 

TY  - CHAP
AU  - Newman, David J.
AD  - U.S. National Cancer Institute
A2  - Hatziolos, Marea E.
A2  - Hooten, Anthony J.
A2  - Fodor, Martin
T1  - Reef-Destructive Practice versus Opportunities for Sustainable Mariculture: Coral Reefs and Pharmacologic Potential
T2  - Coral reefs: Challenges and opportunities for sustainable management: Proceedings of an associated event of the Fifth Annual World Bank Conference on Environmentally and Socially Sustainable Development
PB  - Environmentally and Socially Sustainable Development series.
PB  - Washington, D.C.:
PB  - World Bank
Y1  - 1998///
SP  - 68
EP  - 71
N1  - Accession Number: 0544598; Reviewed Book ISBN: 0-8213-4235-5; ; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200012
KW  - Renewable Resources and Conservation: Water          Q25
KW  - Chemicals; Rubber; Drugs; Biotechnology          L65
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 104796749
T1  - Randomized clinical trial of lifestyle interventions in Pima Indians: a pilot study.
AU  - Narayan, K M
AU  - Hoskin, M
AU  - Kozak, D
AU  - Kriska, A M
AU  - Hanson, R L
AU  - Pettitt, D J
AU  - Nagi, D K
AU  - Bennett, P H
AU  - Knowler, W C
Y1  - 1998/01//
N1  - Accession Number: 104796749. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research; randomized controlled trial. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8500858. 
KW  - Diet
KW  - Exercise Physiology
KW  - Native Americans
KW  - Life Style
KW  - Adult
KW  - Arizona
KW  - Blood Glucose -- Metabolism
KW  - Body Composition -- Physiology
KW  - Body Weight -- Physiology
KW  - Fasting
KW  - Pilot Studies
KW  - Female
KW  - Prospective Studies
KW  - Human
KW  - Insulin -- Blood
KW  - Linear Regression
KW  - Male
KW  - Middle Age
KW  - Risk Factors
KW  - Clinical Trials
SP  - 66
EP  - 72
JO  - Diabetic Medicine
JF  - Diabetic Medicine
JA  - DIABETIC MED
VL  - 15
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0742-3071
AD  - Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Arizona, USA.
U2  - PMID: 9472866.
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DB  - rzh
ER  - 

TY  - JOUR
AU  - Eisenhauer, E.A.
AU  - Vermorken, J.B.
T1  - The Taxoids: Comparative Clinical Pharmacology and Therapeutic Potential.
JO  - Drugs
JF  - Drugs
Y1  - 1998/01//
VL  - 55
IS  - 1
M3  - Article
SP  - 5
EP  - 30
PB  - Springer Science & Business Media B.V.
SN  - 00126667
AB  - Paclitaxel and docetaxel are 2 compounds from the new taxoid class of anticancer agents. Both drugs are very similar in preclinical activity, mechanism of action and spectrum of clinical activity. Some subtle differences in the intracellular retention of docetaxel may account for its lack of schedule-related myelosuppression and greater potency, and may be relevant to the skin toxicity and oedema which it produces. Early data suggest that there may be differing behaviour of anthracycline/taxoid combinations with respect to cardiotoxicity. Paclitaxel has been studied in several first-line combination therapy trials in ovarian cancer. Here, paclitaxel in combination with a platinum compound seems to have proven itself as a standard regimen. It is uncertain if docetaxel will be evaluated in this context. An abundance of clinical data is available for both analogues in the advanced, metastatic setting of breast cancer. Both also have been compared as single agents with doxorubicin with the results suggesting paclitaxel in a 3-hour infusion is inferior to the anthracycline (in terms of response rate), and those of docetaxel suggesting it is superior to the same dose of doxorubicin. This indirect comparison favours the activity of docetaxel; however, it is clear that in the dose/schedules studied, the taxoid compounds are not equitoxic. Either agent by itself, in the treatment of metastatic breast cancer, remains appropriate; however, lack of cumulative toxicity may make paclitaxel more attractive in some situations where prolonged administration is foreseen. Lung cancer trials have also confirmed the activity of both agents, although docetaxel appears to have slightly more promising activity in previously treated patients than paclitaxel. Paclitaxel in combination with cisplatin has been evaluated in randomised trials as first-line treatment of non-small-cell lung cancer (NSCLC). The results of these trials taken together suggest that this combination has an impact on survival similar to other new regimens now considered ‘standard’ in the front-line setting in this disease. Unfortunately, despite all the phase II data generated in numerous tumour types, little else can be said about the role of either taxoid in the ‘standard’ management of malignant disease. It will be some years yet before taxoid-based combinations have been evaluated sufficiently in randomised trials such that the impact of this novel class can be adequately assessed in terms of survival and cure rates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Drugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTINEOPLASTIC agents
KW  - PHARMACOLOGY
KW  - THERAPEUTICS
KW  - DRUGS
KW  - CLINICAL trials
KW  - Antineoplastics, general
KW  - Breast-cancer, treatment
KW  - Clinical-pharmacokinetics
KW  - Docetaxel, adverse-reactions
KW  - Docetaxel, drug-interactions
KW  - Docetaxel, general
KW  - Docetaxel, pharmacokinetics
KW  - Docetaxel, therapeutic-use
KW  - Drug-interactions
KW  - Head-and-neck-cancer, treatment
KW  - Lung-cancer, treatment
KW  - Ovarian-cancer, treatment
KW  - Paclitaxel, adverse-reactions
KW  - Paclitaxel, drug-interactions
KW  - Paclitaxel, general
KW  - Paclitaxel, pharmacokinetics
KW  - Paclitaxel, therapeutic-use
KW  - Reviews-on-treatment
N1  - Accession Number: 9592975; Eisenhauer, E.A. 1 Vermorken, J.B. 2; Affiliation:  1: National Cancer Institute of Canada Clinical Trials Group, Queen's University,Kingston, Ontario, Canada  2: University Hospital Antwerp, Edegem, Belgium; Source Info: Jan1998, Vol. 55 Issue 1, p5; Subject Term: ANTINEOPLASTIC agents; Subject Term: PHARMACOLOGY; Subject Term: THERAPEUTICS; Subject Term: DRUGS; Subject Term: CLINICAL trials; Author-Supplied Keyword: Antineoplastics, general; Author-Supplied Keyword: Breast-cancer, treatment; Author-Supplied Keyword: Clinical-pharmacokinetics; Author-Supplied Keyword: Docetaxel, adverse-reactions; Author-Supplied Keyword: Docetaxel, drug-interactions; Author-Supplied Keyword: Docetaxel, general; Author-Supplied Keyword: Docetaxel, pharmacokinetics; Author-Supplied Keyword: Docetaxel, therapeutic-use; Author-Supplied Keyword: Drug-interactions; Author-Supplied Keyword: Head-and-neck-cancer, treatment; Author-Supplied Keyword: Lung-cancer, treatment; Author-Supplied Keyword: Ovarian-cancer, treatment; Author-Supplied Keyword: Paclitaxel, adverse-reactions; Author-Supplied Keyword: Paclitaxel, drug-interactions; Author-Supplied Keyword: Paclitaxel, general; Author-Supplied Keyword: Paclitaxel, pharmacokinetics; Author-Supplied Keyword: Paclitaxel, therapeutic-use; Author-Supplied Keyword: Reviews-on-treatment; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 26p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107253050
T1  - The potential impact of the 1996 welfare reforms in intimate partner violence.
AU  - Akukwe C
Y1  - 1998/01//1998 Jan
N1  - Accession Number: 107253050. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 7809641. 
KW  - Intimate Partner Violence
KW  - Public Assistance -- Legislation and Jurisprudence -- United States
KW  - United States
KW  - Employment
KW  - Stress, Psychological
KW  - Community Role
KW  - Social Attitudes
KW  - Government Programs
KW  - Female
SP  - 54
EP  - 62
JO  - Family & Community Health
JF  - Family & Community Health
JA  - FAM COMMUNITY HEALTH
VL  - 20
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Intimate partner violence harms millions of women with devastating physical and mental health consequences for them and their children. Low-income women and children are at high risk. The recent welfare legislation with strict work requirements and optional family violence provisions could make many victims choose to stay with their abusers with devastating consequences. This article argues that intimate partner violence extends beyond the current welfare debate and will require careful strategic approaches and partnerships to contain the problem. Durable public, community, and private partnerships at local, state, and national levels are critical to ending this shameful epidemic.
SN  - 0160-6379
AD  - Coordinator, District of Columbia Initiative to Reduce Infant Mortality, Office of Maternal and Child Health, National Institutes of Health, Washington DC
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Streckfus, Charles F.
AU  - Baur, Ursula
AU  - Brown, L. Jackson
AU  - Bacal, Carolyn
AU  - Metter, Jeffrey
AU  - Nick, Todd
T1  - Effects of Estrogen Status and Aging on Salivary Flow Rates in Healthy Caucasian Women.
JO  - Gerontology
JF  - Gerontology
Y1  - 1998/01//
VL  - 44
IS  - 1
M3  - Article
SP  - 32
EP  - 39
SN  - 0304324X
AB  - A comparison of salivary flow rates was made between three groups of female individuals according to their menopausal status. The three groups consisted of healthy, dentate, nonmedicated women (with the exception of the use of estrogen) from the Baltimore Longitudinal Study of Aging. One group consisted of premenopausal women (n = 51), their mean age was 39 years. Another group (n = 26) was perimenopausal with a mean age of 48 years. A third group (n = 76) was postmenopausal with a mean age of 69 years. The groups were evaluated for unstimulated (U[sub PAR] ) and stimulated parotid gland flow rates (S[sub PAR] ), unstimulated (U[sub SUB] ) and stimulated submandibular/sublingual gland flow rates (S[sub SUB] ), and stimulated whole-saliva flow rates (S[sub WHOLE] ). The parotid flow rates were determined using a Carlson-Crittenden cup, while the submandibular/sublingual flow rates were determined using the National Institute of Dental Research collector. A 2% citrate solution was used for stimulation in glandular collections. Chewing a 1-cm[sup 3] cube of paraffin was used to stimulate whole saliva. The results showed no significant differences in U[sub PAR] , S[sub PAR] , and S[sub WHOLE] between the three groups. However, the premenopausal women had higher U[sub SUB] than the postmenopausal group. The premenopausal women also had higher S[sub SUB] than perimenopausal and postmenopausal groups. There were no differences in salivary flow rates between those taking estrogen and those that were not medicated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Gerontology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESTROGEN
KW  - AGING
KW  - SALIVA
KW  - FLUID dynamics
KW  - CAUCASIAN race
KW  - WOMEN
KW  - Estrogen
KW  - Menopause
KW  - Saliva
KW  - Saliva flow rates
N1  - Accession Number: 11373283; Streckfus, Charles F. 1 Baur, Ursula 2 Brown, L. Jackson 3 Bacal, Carolyn 4 Metter, Jeffrey 5 Nick, Todd 1; Affiliation:  1: University of Mississippi Medical Center, School of Dentistry, Jackson, Miss., USA  2: German Academic Exchange Service (DAAD), Bonn, Germany;  3: DEODP, National Institute of Dental Research, National Institutes of Health, Bethesda, Md., USA  4: Johns Hopkins Bayview Medical Center, Baltimore, Md., USA  5: Gerontology Research Center, National Institute of Aging, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 44 Issue 1, p32; Subject Term: ESTROGEN; Subject Term: AGING; Subject Term: SALIVA; Subject Term: FLUID dynamics; Subject Term: CAUCASIAN race; Subject Term: WOMEN; Author-Supplied Keyword: Estrogen; Author-Supplied Keyword: Menopause; Author-Supplied Keyword: Saliva; Author-Supplied Keyword: Saliva flow rates; Number of Pages: 8p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
L3  - 10.1159/000021980
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
ID  - 2005-03131-002
AN  - 2005-03131-002
AU  - Lamb, Michael E.
ED  - Damon, William
ED  - Sigel, Irving E.
ED  - Renninger, K. Ann
ED  - Damon, William, (Ed)
ED  - Sigel, Irving E., (Ed)
ED  - Renninger, K. Ann, (Ed)
T1  - Nonparental Child Care: Context, Quality, Correlates and Consequences.
T2  - Handbook of child psychology: Child psychology in practice, Vol. 4, 5th ed.
Y1  - 1998///
SP  - 73
EP  - 133
CY  - Hoboken, NJ, US
PB  - John Wiley & Sons Inc
SN  - 0-471-34982-8
N1  - Accession Number: 2005-03131-002. Partial author list: First Author & Affiliation: Lamb, Michael E.; Section of Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20050418. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-471-34982-8, Paperback. Language: English. Major Descriptor: Child Care; Child Day Care; Childhood Development; Childrearing Practices; Parents. Minor Descriptor: Consequence. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 61. 
AB  - This chapter is concerned with variations in the extent to which young children receive care from adults other than their parents and the effects that such care arrangements have on their development. As readers will quickly note, the underlying issues are more complex than they appear, and thus our understanding remains quite limited. In addition, researchers have learned in recent years to be wary of facile generalization across contexts or cultures when studying such issues. It is naïve to ask such questions about the universal consequences of child care experiences as Is day care good or bad for children? or Is center day care better for children than family day care? Instead, researchers must examine children's development in the context of the rich array of experiences to which children around the world are exposed. Nonparental care is and has been experienced to a greater or lesser degree in almost every society. Care of poor quality and care patterns that are inconsistent with the other experiences and needs of children may be harmful, but--contrary to the claims of popularizers like White (1985. 1988, 1995)--the evidence reviewed in this chapter makes clear that children are not inevitably harmed just because they experience nonparental care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - day care
KW  - nonparental child care
KW  - child care experiences
KW  - young children
KW  - childhood development
KW  - care patterns
KW  - family day care
KW  - center day care
KW  - 1998
KW  - Child Care
KW  - Child Day Care
KW  - Childhood Development
KW  - Childrearing Practices
KW  - Parents
KW  - Consequence
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107287442
T1  - Demography and epidemiology of dying in the U.S. with emphasis on deaths of older persons...A good dying: shaping health care for the last months of life... the Corcoran Symposium
AU  - Brock DB
AU  - Foley DJ
Y1  - 1998/01//
N1  - Accession Number: 107287442. Language: English. Entry Date: 19981001. Revision Date: 20150820. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. NLM UID: 8505218. 
KW  - Death -- In Old Age -- United States
KW  - Mortality -- In Old Age -- United States
KW  - United States
KW  - Questionnaires
KW  - Functional Status
KW  - Age Factors
KW  - Sex Factors
KW  - Surveys
KW  - Sampling Methods
KW  - Data Collection
KW  - Socioeconomic Factors
KW  - Demography
KW  - Aged
KW  - Aged, 80 and Over
KW  - Health Resource Utilization
SP  - 49
EP  - 60
JO  - Hospice Journal
JF  - Hospice Journal
JA  - HOSP J
VL  - 13
IS  - 1/2
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - As chronic disease continues to be the major cause of death and as the elderly population grows, it is important to evaluate the adequacy and completeness of health care strategies for the elderly. Two studies, the National Mortality Followback Survey and the National Institute on Aging Survey of the Last Days of Life, were designed to examine the circumstances of death for representative samples of decedents. Four areas of focus are location of death, transitions among health care settings, circumstances at the time of death, and changes in physical and cognitive function in the last year of life. Although the data are helpful for family planning, they are limited by a lack of data on costs.
SN  - 0742-969X
AD  - Chief of the Biometry Office, National Institute on Aging, National Institutes of Health, Bethesda, MD
U2  - PMID: 9644392.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yamashiro, Shigeo
AU  - Takeya, Motohiro
AU  - Jun-ichi Kuratsu
AU  - Ushio, Yukitaka
AU  - Takahashi, Kiyoshi
AU  - Yoshimura, Teizo
T1  - Intradermal Injection of Monocyte Chemoattractant Protein-1 Induces Emigration and Differentiation of Blood Monocytes in Rat Skin.
JO  - International Archives of Allergy & Immunology
JF  - International Archives of Allergy & Immunology
Y1  - 1998/01//
VL  - 115
IS  - 1
M3  - Article
SP  - 15
EP  - 23
SN  - 10182438
AB  - Background: Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for blood monocytes in vitro. Recent studies in MCP-1-transgenic mice revealed that the local production of MCP-1 caused monocyte infiltration. However, the kinetics of monocyte infiltration after the production of MCP-1 or the amount of MCP-1 necessary for monocyte recruitment are not known. Methods: We purified recombinant rat MCP-1 expressed in COS-7 cells, and injected it into rat skin. The infiltrating cells were examined by immunohistochemistry and ultrastructural peroxidase cytochemistry. Results: Rat recombinant MCP-1 had a molecular mass of approximately 30 kD and exhibited the peak monocyte chemotactic activity at 10[sup –9] M. One microgram of MCP-1 caused intra- and extravascular accumulation of mononuclear cells 3 h after injection. The cells were ED1+, indicating they were blood monocytes. The infiltration of mononuclear cells peaked at 12–24 h, and most of them were TRPM-3+ and ED3+, characteristic to exudate macrophages. None of the cells expressed ED2 or Ki-M2R antigens, markers for resident macrophages, until 3 days after injection. There was no uptake of [[sup 3] H]thymidine by the infiltrating cells. Ultrastructural peroxidase cytochemistry confirmed that the infiltrating cells were monocytes and exudate macrophages. The number of OX8+ lymphocytes also peaked at 12 h, consisting of approximately 9% of the total infiltrating cells. Conclusion: These results indicate that MCP-1 attracts blood monocytes as early as 3 h and the infiltrating monocytes differentiate into exudate macrophages in loco. However, this effect was transient and the infiltration of monocytes did not result in tissue damage. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Archives of Allergy & Immunology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MONOCYTES
KW  - LEUCOCYTES
KW  - CHEMOKINES
KW  - RATS
KW  - SKIN
KW  - INFLAMMATION -- Mediators
KW  - Chemokine
KW  - Chemotactic factor
KW  - Immunohistochemistry
KW  - Lymphocyte
KW  - Macrophage subpopulation
KW  - Monocyte chemoattractant protein-1
KW  - Ultrastructural study
N1  - Accession Number: 11139865; Yamashiro, Shigeo 1,2 Takeya, Motohiro 1 Jun-ichi Kuratsu 2 Ushio, Yukitaka 2 Takahashi, Kiyoshi 1 Yoshimura, Teizo 3; Affiliation:  1: Second Department of Pathology  2: Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan  3: Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Md., USA; Source Info: Jan1998, Vol. 115 Issue 1, p15; Subject Term: MONOCYTES; Subject Term: LEUCOCYTES; Subject Term: CHEMOKINES; Subject Term: RATS; Subject Term: SKIN; Subject Term: INFLAMMATION -- Mediators; Author-Supplied Keyword: Chemokine; Author-Supplied Keyword: Chemotactic factor; Author-Supplied Keyword: Immunohistochemistry; Author-Supplied Keyword: Lymphocyte; Author-Supplied Keyword: Macrophage subpopulation; Author-Supplied Keyword: Monocyte chemoattractant protein-1; Author-Supplied Keyword: Ultrastructural study; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3  - 10.1159/000023825
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 88318181
T1  - Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
AU  - Varterasian, Mary L.
AU  - Mohammad, Ramzi M.
AU  - Eilender, David S.
AU  - Hulburd, Kim
AU  - Rodriguez, Dorothy H.
AU  - Pemberton, Pamela A.
AU  - Pluda, James M.
AU  - Dan, Maria D.
AU  - Pettit, George R.
AU  - Chen, Ben D. M.
AU  - Al-Katib, Ayad M.
AU  - Varterasian, M L
AU  - Mohammad, R M
AU  - Eilender, D S
AU  - Hulburd, K
AU  - Rodriguez, D H
AU  - Pemberton, P A
AU  - Pluda, J M
AU  - Dan, M D
AU  - Pettit, G R
Y1  - 1998/01//
N1  - Accession Number: 88318181. Language: English. Entry Date: 19980201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: CA 22453-19/CA/NCI NIH HHS/United States. NLM UID: 8309333. 
KW  - Lymphoma, Non-Hodgkin's -- Drug Therapy
KW  - Leukemia, Lymphocytic, Chronic -- Drug Therapy
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Organic Chemicals -- Administration and Dosage
KW  - Recurrence
KW  - Adult
KW  - Muscular Diseases -- Chemically Induced
KW  - Aged
KW  - Human
KW  - Leukemia, Lymphocytic, Chronic -- Metabolism
KW  - Middle Age
KW  - Antibiotics, Macrolide
KW  - Pain -- Chemically Induced
KW  - Drug Administration Schedule
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Male
KW  - Lymphoma, Non-Hodgkin's -- Metabolism
KW  - Organic Chemicals -- Adverse Effects
KW  - Antigens, Surface -- Metabolism
KW  - Female
KW  - Dose-Response Relationship, Drug
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 56
EP  - 62
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To define, in a phase I study in relapsed non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), the maximum-tolerated dose (MTD), major toxicities, and possible antitumor activity of bryostatin 1, a macrocyclic lactone.Patients and Methods: Bryostatin 1 was delivered by 72-hour continuous infusion every 2 weeks to patients with relapsed NHL or CLL, at doses that ranged from 12 microg/m2 to 180 microg/m2 per course. Correlative investigations included evaluations of total protein kinase C (PKC) in peripheral blood and lymphoid differentiation in patient tumor tissue.Results: Twenty-nine patients were treated, including three patients with CLL and 26 with NHL. Generalized myalgia was the dose-limiting toxicity (DLT) and occurred in two of three patients treated with bryostatin 1 at 180 microg/m2 per course. Myalgias were dose-related and cumulative, and often started in the thighs and calves, improved with activity, were somewhat responsive to analgesics, and often took weeks to resolve once taken off study. Six patients were treated at the MTD of 120 microg/m2 per course. Myalgia, headache, and fatigue were common. Hematologic toxicity was uncommon. Total cumulative doses of bryostatin 1 up to 1,134 microg/m2 have been administered without untoward toxicity. Eleven patients achieved stable disease for 2 to 19 months. An in vitro assay for total PKC evaluation in patient peripheral-blood samples demonstrated activation within the first 2 hours with subsequent downregulation by 24 hours, which was maintained throughout the duration of the 72-hour infusion.Conclusion: This phase I study defined the MTD and recommended phase II dose of bryostatin 1, when administered over 72 hours every 2 weeks, to be 120 microg/m2 (40 microg/m2/d for 3 days). Generalized myalgia was the DLT. Future studies will define the precise activity of bryostatin 1 in subsets of patients with lymphoproliferative malignancies and its efficacy in combination with other agents.
SN  - 0732-183X
AD  - Harper Hospital, Division of Hematology and Oncology, 3990 John R, 4 Brush South, Detroit, MI 48201
AD  - Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute, Rockville, MD
AD  - Department of Chemistry, Arizona State University, Tempe, AZ
AD  - Karmanos Cancer Institute and Wayne State University, Detroit, MI, USA
U2  - PMID: 9440723.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88318141
T1  - Phase I trial and pharmacokinetic study of pyrazoloacridine in children and young adults with refractory cancers.
AU  - Berg, Stacey L.
AU  - Blaney, Susan M.
AU  - Adamson, Peter C.
AU  - O'Brien, Michelle
AU  - Poplack, David G.
AU  - Arndt, Carola
AU  - Blatt, Julie
AU  - Balis, Frank M.
AU  - Berg, S L
AU  - Blaney, S M
AU  - Adamson, P C
AU  - O'Brien, M
AU  - Poplack, D G
AU  - Arndt, C
AU  - Blatt, J
AU  - Balis, F M
Y1  - 1998/01//
N1  - Accession Number: 88318141. Language: English. Entry Date: 19980201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Profile of Mood States (POMS); Longitudinal Interval Follow-Up Evaluation (LIFE). NLM UID: 8309333. 
KW  - Heterocyclic Compounds -- Pharmacokinetics
KW  - Heterocyclic Compounds -- Administration and Dosage
KW  - Neoplasms -- Drug Therapy
KW  - Antineoplastic Agents -- Pharmacokinetics
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Neoplasms -- Metabolism
KW  - Drug Administration Schedule
KW  - Male
KW  - Infusions, Intravenous
KW  - Adult
KW  - Heterocyclic Compounds -- Adverse Effects
KW  - Antineoplastic Agents -- Blood
KW  - Neutropenia -- Chemically Induced
KW  - Child
KW  - Heterocyclic Compounds -- Blood
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Adolescence
KW  - Child, Preschool
KW  - Female
KW  - Thrombocytopenia -- Chemically Induced
KW  - Infant
KW  - Human
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 181
EP  - 186
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To define the maximum-tolerated dose (MTD), quantitative and qualitative toxicities, recommended phase II dose, and pharmacokinetics of pyrazoloacridine (PZA) administered as a 1- or 24-hour infusion in children and young adults with refractory cancers.Patients and Methods: Twenty-two patients received PZA as a 1-hour infusion at doses of 380 mg/m2 (n = 3), 495 mg/m2 (n = 6), 640 mg/m2 (n = 6), and 835 mg/m2 (n = 7). An additional four patients received PZA as a 24-hour infusion at the MTD (640 mg/m2) for the 1-hour infusion schedule. Plasma samples were obtained for pharmacokinetic analysis in 17 patients. PZA concentration in plasma was measured by reverse-phase high-performance liquid chromatography (HPLC). A two-compartment pharmacokinetic model was fit to the PZA plasma concentration data.Results: On the 1-hour infusion schedule, dose-limiting myelosuppression (neutropenia more than thrombocytopenia) was observed in two of seven patients at the 835-mg/m2 dose level. Myelosuppression did not appear to be ameliorated by prolonging the infusion to 24 hours. Nonhematologic toxicities were minor. Significant neurotoxicity, which was dose-limiting in adults treated with a 1-hour infusion of PZA, was observed in one patient treated at 640 mg/m2, but was not dose-limiting. There was marked interpatient variability in plasma PZA concentrations at all dose levels. The pharmacokinetic profile of PZA was characterized by an initial rapid decline (alpha half-life [t(1/2)alpha], 0.5 hours) followed by a prolonged elimination phase (t(1/2)beta, 30 hours). The volume of distribution at steady-state (Vd(ss)) was 700 L/m2 and the clearance was 300 mL/min/m2. There was no evidence of dose-dependent clearance. The area under the PZA concentration-time curve (AUC) correlated poorly with dose and was more predictive of the degree of myelosuppression than was PZA dose.Conclusion: PZA administered as 1- or 24-hour infusion is well tolerated by children and young adults. The dose-limiting toxicity (DLT) is myelosuppression. Neurotoxicity is not prominent in this age group. There was marked interpatient variation in plasma concentrations of PZA. The recommended dose for phase II studies is 640 mg/m2.
SN  - 0732-183X
AD  - Texas Children's Cancer Center, Baylor College of Medicine, 6621 Fannin St, MC 3-3320, Houston, TX 77030
AD  - Texas Children's Cancer Center Texas Children's Hospital and Baylor College of Medicine, Houston, TX
AD  - Pediatric Branch, National Cancer Institute, Bethesda, MD
AD  - Mayo Clinic, Rochester, MN
AD  - Children's Hospital of Pittsburgh, Pittsburgh, PA
AD  - Texas Children's Cancer Center, Texas Children's Hospital and Baylor College of Medicine, Houston 77030, USA
U2  - PMID: 9440741.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88318144
T1  - Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity.
AU  - Yang, James C.
AU  - Chang, Alfred E.
AU  - Baker, Alan R.
AU  - Sindelar, William F.
AU  - Danforth, David N.
AU  - Topalian, Suzanne L.
AU  - DeLaney, Thomas
AU  - Glatstein, Eli
AU  - Steinberg, Seth M.
AU  - Merino, Maria J.
AU  - Rosenberg, Steven A.
AU  - Yang, J C
AU  - Chang, A E
AU  - Baker, A R
AU  - Sindelar, W F
AU  - Danforth, D N
AU  - Topalian, S L
AU  - DeLaney, T
AU  - Glatstein, E
AU  - Steinberg, S M
Y1  - 1998/01//
N1  - Accession Number: 88318144. Language: English. Entry Date: 19980201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Impact of Events Scale (IES); Ferrans and Powers Quality of Life Index; Longitudinal Interval Follow-Up Evaluation (LIFE); Global Assessment of Functioning Scale (GAF). NLM UID: 8309333. 
KW  - Sarcoma -- Surgery
KW  - Sarcoma -- Radiotherapy
KW  - Neoplasm Recurrence, Local -- Prevention and Control
KW  - Extremities
KW  - Female
KW  - Human
KW  - Quality of Life
KW  - Prospective Studies
KW  - Male
KW  - Radiotherapy, Adjuvant
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Randomized Controlled Trials
KW  - Ferrans and Powers Quality of Life Index
KW  - Impact of Events Scale
KW  - Scales
SP  - 197
EP  - 203
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: This randomized, prospective study assesses the impact of postoperative external-beam radiation therapy on local recurrence (LR), overall survival (OS), and quality of life after limb-sparing resection of extremity sarcomas.Patients and Methods: Patients with extremity tumors and a limb-sparing surgical option were randomized to receive or not receive postoperative adjuvant external-beam radiotherapy. Patients with high-grade sarcomas received postoperative adjuvant chemotherapy whereas patients with low-grade sarcomas or locally aggressive nonmalignant tumors were randomized after surgery alone.Results: Ninety-one patients with high-grade lesions were randomized; 47 to receive radiotherapy (XRT) and 44 to not receive XRT. With a median follow-up of 9.6 years, a highly significant decrease (P2 = .0028) in the probability of LR was seen with radiation, but no difference in OS was shown. Of 50 patients with low-grade lesions (24 randomized to resection alone and 26 to resection and postoperative XRT), there was also a lower probability of LR (P2 = .016) in patients receiving XRT, again, without a difference in OS. A concurrent quality-of-life study showed that extremity radiotherapy resulted in significantly worse limb strength, edema, and range of motion, but these deficits were often transient and had few measurable effects on activities of daily life or global quality of life.Conclusion: This study indicates that although postoperative external-beam radiotherapy is highly effective in preventing LRs, selected patients with extremity soft tissue sarcoma who have a low risk of LR may not require adjuvant XRT after limb-sparing surgery (LSS).
SN  - 0732-183X
AD  - Surgery Branch, National Cancer Institute, Building 10, Room 2B37, Bethesda, MD 20892
AD  - Surgery Branch, Radiation Oncology Branch, Biostatistics and Data Management Section, and Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD
AD  - Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA
U2  - PMID: 9440743.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88318158
T1  - Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer.
AU  - O'Connell, Michael J.
AU  - Laurie, John A.
AU  - Kahn, Michael
AU  - Fitzgibbons Jr, Robert J.
AU  - Erlichman, Charles
AU  - Shepherd, Lois
AU  - Moertel, Charles G.
AU  - Kocha, Walter
AU  - Pazdur, Richard
AU  - Wieand, H. Sam
AU  - Rubin, Joseph
AU  - Vukov, Allen M.
AU  - Donohue, John H.
AU  - Krook, James E.
AU  - Figueredo, Alvaro
AU  - O'Connell, M J
AU  - Laurie, J A
AU  - Kahn, M
AU  - Fitzgibbons, R J Jr
AU  - Erlichman, C
Y1  - 1998/01//
N1  - Accession Number: 88318158. Language: English. Entry Date: 19980201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). NLM UID: 8309333. 
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Adenocarcinoma -- Drug Therapy
KW  - Colonic Neoplasms -- Drug Therapy
KW  - Adenocarcinoma -- Surgery
KW  - Colonic Neoplasms -- Surgery
KW  - Adenocarcinoma -- Mortality
KW  - Middle Age
KW  - Aged
KW  - Leucovorin -- Administration and Dosage
KW  - Prospective Studies
KW  - Colonic Neoplasms -- Pathology
KW  - Antidotes -- Administration and Dosage
KW  - Imidazoles -- Administration and Dosage
KW  - Adult
KW  - Aged, 80 and Over
KW  - Adolescence
KW  - Colonic Neoplasms -- Mortality
KW  - Chemotherapy, Adjuvant
KW  - Female
KW  - Male
KW  - Human
KW  - Adenocarcinoma -- Pathology
KW  - Fluorouracil -- Administration and Dosage
KW  - Neoplasm Staging
KW  - Biological Response Modifiers -- Administration and Dosage
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Randomized Controlled Trials
KW  - Scales
SP  - 295
EP  - 300
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: This study had two major goals: (1) to assess the effectiveness of a regimen of fluorouracil (5-FU) plus levamisole plus leucovorin as postoperative surgical adjuvant therapy for patients with high-risk colon cancer, and (2) to evaluate 6 months versus 12 months of chemotherapy.Patients and Methods: Patients with poor-prognosis stage II or III colon cancer were randomly assigned to receive adjuvant chemotherapy with either intensive-course 5-FU and leucovorin combined with levamisole, or a standard regimen of 5-FU plus levamisole. Patients were also randomly assigned to receive either 12 months or 6 months of chemotherapy, which resulted in four treatment groups.Results: Eight hundred ninety-one of 915 patients entered (97.4%) were eligible. The median follow-up duration is 5.1 years for patients still alive. There was a difference among the four treatment groups with respect to patient survival, and a significant duration-by-regimen interaction was observed. Specifically, standard 5-FU plus levamisole was inferior to 5-FU plus leucovorin plus levamisole when treatment was given for 6 months (5-year survival rate, 60% v 70%; P < .01).Conclusion: There was no significant improvement in patient survival when chemotherapy was given for 12 months compared with 6 months. When chemotherapy was given for 6 months, standard 5-FU plus levamisole was associated with inferior patient survival compared with intensive-course 5-FU plus leucovorin plus levamisole. These data suggest that 5-FU plus levamisole for 6 months should not be used in clinical practice, whereas 6 months of treatment with 5-FU plus leucovorin plus levamisole is effective.
SN  - 0732-183X
AD  - Department of Oncology, Mayo Clinic, 200 First St SW Rochester, MN 55905
AD  - Mayo Clinic and Mayo Foundation, Rochester
AD  - Duluth Community Clinical Oncology Program, Duluth, MN
AD  - Grand Forks Clinic, Ltd, Grand Forks, ND
AD  - Nebraska Oncology Group-Creighton University, University of Nebraska Medical Center, and Associates, Omaha, NE
AD  - National Cancer Institute of Canada Clinical Trials Group, Queens University, Kingston, Canada
AD  - Anderson Hospital, Houston, TX
AD  - Illinois Oncology Research Association Community Clinical Oncology Program, Peoria, IL
AD  - Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
U2  - PMID: 9440756.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
ID  - 88318176
T1  - Secrecy for data monitoring committees: inferior ethics, bad policy.
AU  - Wells, Robert J.
AU  - Smith, Malcolm A.
AU  - Ungerleider, Richard S.
AU  - Korn, Edward L.
AU  - Rubinstein, Lawrence
AU  - Simon, Richard
AU  - Wells, R J
Y1  - 1998/01//
N1  - Accession Number: 88318176. Language: English. Entry Date: 19980201. Revision Date: 20161120. Publication Type: commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Clinical Trials -- Standards
KW  - Communication
KW  - Health Policy
KW  - Ethics, Medical
KW  - Clinical Trials
KW  - Policy Making
KW  - Public Policy
KW  - Government Regulations
KW  - Consent
KW  - Research Subjects
KW  - Trust
KW  - United States
KW  - Truth Disclosure
SP  - 390
EP  - 391
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
SN  - 0732-183X
AD  - Children's Hospital Medical Center Cincinnati, OH
AD  - National Cancer Institute, Bethesda, MD
U2  - PMID: 9440771.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107278536
T1  - The effects of fluency-evoking conditions on voicing onset types in persons who do and do not stutter.
AU  - Stager SV
AU  - Ludlow CL
Y1  - 1998/01//1998 Jan-Feb
N1  - Accession Number: 107278536. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0260316. 
KW  - Fluency Disorders
KW  - Acoustic Stimulation
KW  - Perceptual Masking
KW  - Phonation -- Physiology
KW  - Case Control Studies
KW  - Comparative Studies
KW  - Female
KW  - Male
KW  - Adult
KW  - Middle Age
KW  - Noise
KW  - Audiorecording
KW  - Respiratory Airflow
KW  - Descriptive Statistics
KW  - Mann-Whitney U Test
KW  - Chi Square Test
KW  - Paired T-Tests
KW  - Mantel-Haenszel Test
KW  - Speech Production Measurement
KW  - Voice Quality -- Physiology
KW  - Education, Continuing (Credit)
KW  - Human
SP  - 33
EP  - 86
JO  - Journal of Communication Disorders
JF  - Journal of Communication Disorders
JA  - J COMMUN DISORD
VL  - 31
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
SN  - 0021-9924
AD  - Language Section, VSLB, NIDCD, Building 10, Room 5N-118A, 10 Center Drive MSC 1407, Bethesda, Maryland 20892-1407
U2  - PMID: 9421766.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Delporte, Christine
AU  - Miller, Georgina
AU  - Kagami, Hideaki
AU  - Lililbrldge, C. David
AU  - O'connell, Brian C.
AU  - Atkinson, Jane C.
AU  - Baum, Bruce J.
T1  - Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats.
JO  - Journal of Oral Pathology & Medicine
JF  - Journal of Oral Pathology & Medicine
Y1  - 1998/01//
VL  - 27
IS  - 1
M3  - Article
SP  - 34
EP  - 38
SN  - 09042512
AB  - We have examined the safety of a replication-deficient recombinant adenovirus administered at a single, high dose intraductally to rat submandibular glands or systemically via the femoral vein. The virus used directed the synthesis of human aquaporin- 1, a water channel protein, and is termed AdhAQPI. Comparisons were made 1 and 9 days post-infection with animals administered either a similar virus encoding no transgene or the viral suspension buffer. Animals were specifically not given anti-inflammatory drugs to impede the well-known immunopathologic response to recombinant adenoviral administration. Serum chemistries and hematological parameters were monitored. Rats were subjected to complete gross necropsy and selected tissues were evaluated by histopathology. Most clinical chemistry and hematology values were within normal ranges; however, evidence of inflammation (e.g., elevated lactic dehydrogenase, total leukocyte count) was seen. Gross pathology was normal, as was histopathology, excepting rare focal areas of necrosis. The results show that intrasalivary gland or intravenous AdhAQPI administration leads to low levels of toxicity in rats. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VIRUSES
KW  - PATHOLOGICAL histology
KW  - PATHOLOGY
KW  - BLOOD-vessels
KW  - BLOOD plasma
KW  - INTERNAL medicine
KW  - adenovrus
KW  - aquaporin-1
KW  - gene transfer
KW  - safety
KW  - salivary gland.
N1  - Accession Number: 13079025; Delporte, Christine 1 Miller, Georgina 2 Kagami, Hideaki 1 Lililbrldge, C. David 1 O'connell, Brian C. 1 Atkinson, Jane C. 1 Baum, Bruce J. 1; Affiliation:  1: Gene Therapy and Therapeutics Branch, National Institute of Dental Research.  2: Veterinatry Resources Program, National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA.; Source Info: Jan1998, Vol. 27 Issue 1, p34; Subject Term: VIRUSES; Subject Term: PATHOLOGICAL histology; Subject Term: PATHOLOGY; Subject Term: BLOOD-vessels; Subject Term: BLOOD plasma; Subject Term: INTERNAL medicine; Author-Supplied Keyword: adenovrus; Author-Supplied Keyword: aquaporin-1; Author-Supplied Keyword: gene transfer; Author-Supplied Keyword: safety; Author-Supplied Keyword: salivary gland.; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bremner, J. Douglas
AU  - Krystal, John H.
AU  - Putnam, Frank W.
AU  - Southwick, Steven M.
AU  - Marmar, Charles
AU  - Charney, Dennis S.
AU  - Mazure, Carolyn M.
T1  - Measurement of Dissociative States with the Clinician-Administered Dissociative States Scale (CADSS).
JO  - Journal of Traumatic Stress
JF  - Journal of Traumatic Stress
Y1  - 1998/01//
VL  - 11
IS  - 1
M3  - Article
SP  - 125
EP  - 136
PB  - John Wiley & Sons, Inc.
SN  - 08949867
AB  - The purpose of this study was to develop an instrument for the measurement of present-state dissociative symptoms, the Clinician Administered Dissociative States Scale (CADSS). Reported here are interrater reliability and internal consistency of the CADSS, validity as assessed by comparisons with other instruments for the assessment of dissociation, and sensitivity of the CADSS to discriminate patients with dissociative disorders from patients with other psychiatric disorders and healthy subjects. Initial analyses indicated good interrater reliability and construct validity for the CADSS. Scores on the CADSS discriminated patients with dissociative disorders from the other groups. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Traumatic Stress is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SCALING (Social sciences)
KW  - DISSOCIATIVE disorders
KW  - PATHOLOGICAL psychology
KW  - MENTAL illness
KW  - MEDICAL personnel
KW  - PSYCHOMETRICS
KW  - dissociation
KW  - psychometrics
KW  - PTSD
KW  - trauma
N1  - Accession Number: 278235; Bremner, J. Douglas 1,2 Krystal, John H. 1,3,4 Putnam, Frank W. 5 Southwick, Steven M. Marmar, Charles 6,7 Charney, Dennis S. 1,3,4 Mazure, Carolyn M. 4; Affiliation:  1: West Haven VA Medical Center, West Haven, Connecticut.  2: Yale Psychiatric Institute, New Haven, Connecticut 06520.  3: National Center for Posttraumatic Stress Disorder, Division of Clinical Neurosciences, West Haven Connecticut 06516.  4: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520.  5: National Institute of Mental Health, Bethesda, Maryland 20892.  6: San Francisco VA Medical Center, San Francisco, California.  7: Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143.; Source Info: Jan98, Vol. 11 Issue 1, p125; Subject Term: SCALING (Social sciences); Subject Term: DISSOCIATIVE disorders; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL illness; Subject Term: MEDICAL personnel; Subject Term: PSYCHOMETRICS; Author-Supplied Keyword: dissociation; Author-Supplied Keyword: psychometrics; Author-Supplied Keyword: PTSD; Author-Supplied Keyword: trauma; Number of Pages: 12p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Dillon, Deborah
AU  - Combes, Robert
AU  - Zeiger, Errol
T1  - The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/01//
VL  - 13
IS  - 1
M3  - Article
SP  - 19
EP  - 26
PB  - Oxford University Press / USA
SN  - 02678357
AB  - Several aldehydes and peroxides were tested for mutagenicity using Salmonella typhimurium tester strains TA97a, TA100, TA102 and TA104, in the presence and absence of Aroclor-induced liver S9 mix from F344 rats and B6C3F1 mice, in either preincubation or vapour phase rotocols. Some chemicals were tested in additional Salmonella strains. Benzaldehyde, butyraldehyde, benzoyl peroxide, 4-chlorobenzaldehyde, isobutyraldehyde, propionaldehyde and veratraldehyde were non-mutagenic Acetaldehyde and dicumyl peroxide gave inconsistent results and furfural gave equivocal responses in TA100 and TA104. Cumene hydroperoxide, formaldehyde and glutaraldehyde were mutagenic in TA100, TA102 and TA104. trans-Cinnamaldehyde exhibited a weak mutagenic response in TA100 with mouse liver S9 only. 2,4,5-Trimethoxybenzaldehyde was mutagenic only in strain TA1538 with rat liver S9. With the exception of butanone peroxide, which was mutagenic only in TA104, all chemicals mutagenic in strains TA102 and/or TA104 were also mutagenic in TA100. The data do not, therefore, support the preferential use of strains TA102 and TA104 for screening aldehydes and peroxides for mutagenicity. For a number of these chemicals the advantages of using TA102 or TA104 was in the increased responses compared with those obtained with TA100. Two of the four peroxides were mutagenic and one of these was mutagenic only with TA104. This suggests that strains TA102 and TA104 be used if peroxides are not mutagemc in TA100 or TA97. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutagenicity testing
KW  - Salmonella
KW  - Peroxides
KW  - Toxicological chemistry
KW  - Aldehydes
KW  - Mutagens -- Analysis
KW  - Mutagenesis
N1  - Accession Number: 79237936; Dillon, Deborah 1; Combes, Robert 1; Zeiger, Errol 2; Affiliations: 1: Inveresk Research International Ltd Tranent EH33 2NE, UK; 2: National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA; Issue Info: Jan1998, Vol. 13 Issue 1, p19; Thesaurus Term: Mutagenicity testing; Thesaurus Term: Salmonella; Thesaurus Term: Peroxides; Thesaurus Term: Toxicological chemistry; Subject Term: Aldehydes; Subject Term: Mutagens -- Analysis; Subject Term: Mutagenesis; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kaler, Stephen G.
T1  - Metabolic and Molecular Bases of Menkes Disease and Occipital Horn Syndrome.
JO  - Pediatric & Developmental Pathology
JF  - Pediatric & Developmental Pathology
Y1  - 1998/01//
VL  - 1
IS  - 1
M3  - Article
SP  - 85
EP  - 98
SN  - 10935266
N1  - Accession Number: 71790820; Kaler, Stephen G. 1; Affiliation:  1: Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA , US; Source Info: Jan1998, Vol. 1 Issue 1, p85; Number of Pages: 14p; Document Type: Article
L3  - 10.1007/s100249900011
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107167111
T1  - Current status of solvent/detergent-treated frozen plasma.
AU  - Klein HG
AU  - Dodd RY
AU  - Dzik WH
AU  - Luban NL
AU  - Ness PM
AU  - Pisciotto P
AU  - Schiff PD
AU  - Snyder EL
Y1  - 1998/01//
N1  - Accession Number: 107167111. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - Plasma
KW  - Blood Preservation
KW  - Solvents -- Therapeutic Use
KW  - Detergents -- Therapeutic Use
SP  - 102
EP  - 107
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 38
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - Department of Transfusion Medicine, Warren G. Magnuson clinical Center, Building 10, Room 1C-711, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 9482404.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2004-17579-028
AN  - 2004-17579-028
AU  - Lamb, Michael E.
T1  - Generative Conceptions of Fatherhood.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1998/01//
VL  - 43
IS  - 1
SP  - 49
EP  - 50
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17579-028. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; National Institute of Child Health and Human Development, Section on Social and Emotional Development, Bethesda, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childrearing Practices; Father Child Relations; Fathers; Parental Role. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30). Reviewed Item: Hawkins, Alan J. (Ed); Dollahite, David C. (Ed). Generative Fathering: Beyond Deficit Perspectives=Thousand Oaks, CA: Sage, 1997. 279 pp; 1997. References Available: Y. Page Count: 2. Issue Publication Date: Jan, 1998. 
AB  - Review of 'Generative Fathering: Beyond Deficit Perspectives' (see record [rid]1997-97192-000[/rid]). All of the contributors to this volume place the concept of generative fathering, and a related notion, 'fatherwork,' at the center of their discussions, and this ensures a laudable degree of coherence that is rare for edited volumes. On a broader level, the editors suggest, the concept of generative fathering also permits a more inclusive and comprehensive analysis and understanding of fatherhood than has hitherto been possible. The review summarizes the book and believes, overall, the book is best viewed as a stimulus to further thought rather than as the definitive and integrative statement about fatherhood or as a primer for providers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - generative fathering
KW  - perspectives
KW  - fatherwork
KW  - fatherhood
KW  - 1998
KW  - Childrearing Practices
KW  - Father Child Relations
KW  - Fathers
KW  - Parental Role
KW  - 1998
U2  - Hawkins, Alan J. (Ed); Dollahite, David C. (Ed). (1997); Generative Fathering: Beyond Deficit Perspectives; Thousand Oaks, CA: Sage, 1997. 279 pp; 0-7619-0117-5 (Hardcover); 0-7619-0118-3 (Paperback).
DO  - 10.1037/001464
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-16121-001
AN  - 2005-16121-001
AU  - Jezova, Daniela
AU  - Ochedalski, Tomasz
AU  - Kiss, Alexander
AU  - Aguilera, Greti
T1  - Brain Angiotensin II Modulates Sympathoadrenal and Hypothalamic Pituitary Adrenocortical Activation during Stress.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1998/01//
VL  - 10
IS  - 1
SP  - 67
EP  - 72
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - Aguilera, Greti, Section on Endocrine Physiology, Developmental Endocrinology Branch, NICHD, NIH, Building 10, Room 10N262, 10 Center Drive, MSC 1862, Bethesda, MD, US, 20892-1862
N1  - Accession Number: 2005-16121-001. PMID: 9510060 Partial author list: First Author & Affiliation: Jezova, Daniela; Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Angiotensin; Brain; Catecholamines; Hypothalamic Pituitary Adrenal Axis; Stress. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jan, 1998. 
AB  - Angiotensin II (Ang II) type-1 (AT₁) receptors are present in areas of the brain controlling autonomic nervous activity and the hypothalamic-pituitary-adrenal (HPA) axis, including CRH cells in the hypothalamic paraventricular nucleus (PVN). To determine whether brain AT₁ receptors are involved in the activation of the HPA axis and sympathetic system during stress, we studied the effects of acute immobilization stress on plasma catecholamines, ACTH and corticosterone, and mRNA levels of CRH and CRH receptors (CRH-R) in the PVN in rats under central AT₁ receptor blockade by the selective antagonist, Losartan. While basal levels of epinephrine, norepinephrine and dopamine in plasma were unaffected 30 min after icv injection of Losartan (10 μg), the increases after 5 and 20 min stress were blunted in Losartan treated rats (P<0.05 for norepinephrine, and P<0.01 for epinephrine and dopamine, vs controls). Basal or stress-stimulated plasma ACTH and corticosterone levels were unaffected by icv Losartan treatment. Using in situ hybridization studies, basal levels of CRH mRNA and CRH-R mRNA in the PVN were unchanged after icv Losartan. While Losartan had no effect on the increases in CRH-R mRNA levels 2 or 3 h after 1 h immobilization, it prevented the increases in CRH mRNA. The blunted plasma catecholamine responses after central AT₁ receptor blockade indicate that endogenous Ang II in the brain is required for sympathoadrenal activation during immobilization stress. While Ang II appears not to be involved in the acute secretory response of the HPA axis, it may play a role in regulating CRH expression in the PVN. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain receptors
KW  - hypothalamic pituitary adrenal axis
KW  - angiotensin II
KW  - sympathetic system
KW  - stress
KW  - acute immobilization stress
KW  - plasma catecholamines
KW  - 1998
KW  - Angiotensin
KW  - Brain
KW  - Catecholamines
KW  - Hypothalamic Pituitary Adrenal Axis
KW  - Stress
KW  - Rats
KW  - 1998
DO  - 10.1046/j.1365-2826.1998.00182.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40277-029
AN  - 2015-40277-029
AU  - Chub, Nikolai
AU  - O'Donovan, Michael J.
T1  - Blockade and recovery of spontaneous rhythmic activity after application of neurotransmitter antagonists to spinal networks of the chick embryo.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/01//
VL  - 18
IS  - 1
SP  - 294
EP  - 306
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - O'Donovan, Michael J., National Institutes of Health, Room 3A50, Building 49, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-40277-029. PMID: 9412508 Partial author list: First Author & Affiliation: Chub, Nikolai; Section on Developmental Neurobiology, Laboratory of Neural Control, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160825. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Motor Neurons; Neural Plasticity; Neural Receptors; Neurotransmitters; Biological Neural Networks. Minor Descriptor: Neural Development; Spinal Cord. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jan, 1998. Publication History: Accepted Date: Oct 16, 1997; Revised Date: Oct 9, 1997; First Submitted Date: May 19, 1997. Copyright Statement: Society for Neuroscience. 1997. 
AB  - We studied the regulation of spontaneous activity in the embryonic (day 10–11) chick spinal cord. After bath application of either an excitatory amino acid (AP-5 or CNQX) and a nicotinic cholinergic (DHβE or mecamylamine) antagonist, or glycine and GABA receptor (bicuculline, 2-hydroxysaclofen, and strychnine) antagonists, spontaneous activity was blocked for a period (30–90 min) but then reappeared in the presence of the drugs. The efficacy of the antagonists was assessed by their continued ability to block spinal reflex pathways during the reappearance of spontaneous activity. Spontaneous activity ceased over the 4–5 hour monitoring period when both sets of antagonists were applied together. After application of glycine and GABA receptor antagonists, the frequency of occurrence of spontaneous episodes slowed and became highly variable. By contrast, during glutamatergic and nicotinic cholinergic blockade, the frequency of occurrence of spontaneous episodes initially slowed and then recovered to stabilize near the predrug level of activity. Whole-cell recordings made from ventral spinal neurons revealed that this recovery was accompanied by an increase in the amplitude of spontaneously occurring synaptic events. We also measured changes in the apparent equilibrium potential of the rhythmic, synaptic drive of ventral spinal neurons using voltage or discontinuous current clamp. After excitatory blockade, the apparent equilibrium potential of the rhythmic synaptic drive shifted ∼10 mV more negative to approximately -30 mV. In the presence of bicuculline, the apparent equilibrium potential of the synaptic drive shifted toward the glutamate equilibrium potential. Considered with other evidence, these findings suggest that spontaneous rhythmic output is a general property of developing spinal networks, and that GABA and glycinergic networks alter their function to compensate for the blockade of excitatory transmission. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - spinal plasticity
KW  - rhythmicity
KW  - embryonic networks
KW  - development
KW  - motoneurons
KW  - spontaneous neural activity
KW  - 1998
KW  - Motor Neurons
KW  - Neural Plasticity
KW  - Neural Receptors
KW  - Neurotransmitters
KW  - Biological Neural Networks
KW  - Neural Development
KW  - Spinal Cord
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13194-036
AN  - 2008-13194-036
AU  - Serafini, R.
AU  - Maric, D.
AU  - Maric, I.
AU  - Ma, W.
AU  - Fritschy, J. M.
AU  - Zhang, L.
AU  - Barker, J. L.
T1  - Dominant GABAA receptor/Cl- channel kinetics correlate with the relative expressions of α2, α3, α5 and β3 subunits in embryonic rat neurones.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/01//
VL  - 10
IS  - 1
SP  - 334
EP  - 349
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-816X
SN  - 1460-9568
AD  - Barker, J. L., Laboratory of Neurophysiology, NINDS/NIH, Building 36, Room 2C-02, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13194-036. PMID: 9753142 Partial author list: First Author & Affiliation: Serafini, R.; Department of Anaesthesiology Research Unit, Washington University School of Medicine, Saint Louis, MO, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20100524. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Neurons; Chloride Channel. Minor Descriptor: Embryo; Gamma Aminobutyric Acid Agonists; Neural Receptors; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Jan, 1998. Publication History: Accepted Date: Aug 22, 1997; Revised Date: Aug 12, 1997; First Submitted Date: Apr 1, 1997. Copyright Statement: European Neuroscience Association
AB  - The embryonic appearance of GABAergic cells and signals in the rat nervous system coincides with the appearance of transcripts encoding some but not all of the subunits forming GABAA receptor/Cl- channels. Quantitative in situ hybridization studies reveal higher variabilities in α₂ and α₃ subunit transcripts relative to others examined (α₅, β₂, β₃ and γ₂) in six spinal and supraspinal regions. Immunocytochemistry of cells dissociated from the embryonic CNS shows that α₂ and α₃ subunits are detectable in differentiating neurones. FACS analyses of dissociated cells immunostained with α₂‐ or α₃‐ antibodies reveal immunopositive subpopulations of variable size in each region. Whole‐cell recordings of acutely adherent neurones show that GABA activates Cl- currents whose fluctuations characteristically vary depending on a neurone's region of origin. Spectral analyses indicate a predominance of the low frequency (< 5 Hz) components, which vary regionally. Regression analyses reveal that (i) channel properties correlate with subunit transcript levels and (ii) dominant channel kinetics correlate with α₂ and α₃ subunit transcripts indexed as a ratio and with coexpressions of α₅ and β₃. The correlations strongly suggest that α₃ subunits in embryonic neurones are expressed in native receptor/channel complexes with slower kinetics than those containing α₂ without α₃ subunits. Thus, GABAA receptor/Cl- channels in these embryonic neurones may be encoded by the six transcripts (α₂, α₃, α₅, and β₂, β₃, and γ₂) with proportions of α₂, α₃, α₅, and β₃ subunits critical in determining their dominant kinetics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - gamma aminobutyric acid agonists receptors
KW  - chloride channels
KW  - embryonic rat neurones
KW  - central nervous system
KW  - 1998
KW  - Central Nervous System
KW  - Neurons
KW  - Chloride Channel
KW  - Embryo
KW  - Gamma Aminobutyric Acid Agonists
KW  - Neural Receptors
KW  - Rats
KW  - 1998
DO  - 10.1046/j.1460-9568.1998.00022.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13194-036&site=ehost-live&scope=site
UR  - jlbarker@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13194-043
AN  - 2008-13194-043
AU  - Strata, Fabrizio
AU  - Atzori, Marco
AU  - Molnar, Margherita
AU  - Ugolini, Gabriele
AU  - Berretta, Nicola
AU  - Cherubini, Enrico
T1  - Nitric oxide sensitive depolarization-induced hyperpolarization: A possible role for gap junctions during development.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/01//
VL  - 10
IS  - 1
SP  - 397
EP  - 403
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-816X
SN  - 1460-9568
AD  - Strata, Fabrizio, Department of Psychology, Vanderbilt University, 301 Wilson Hall, 21st Avenue South, Nashville, TN, US, 37240
N1  - Accession Number: 2008-13194-043. PMID: 9753149 Partial author list: First Author & Affiliation: Strata, Fabrizio; Department of Psychology, Vanderbilt University, Nashville, TN, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20100524. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Depolarization; Hyperpolarization; Gap Junctions. Minor Descriptor: Brain Development; Gamma Aminobutyric Acid; Hippocampus; Nitric Oxide; Rats. Classification: Electrophysiology (2530). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 1998. Publication History: Accepted Date: Aug 15, 1997; Revised Date: Jun 13, 1997; First Submitted Date: Mar 7, 1997. Copyright Statement: European Neuroscience Association
AB  - Electrical coupling is a widespread feature of developing neuronal circuits and it contributes to the generation of patterned activity. In the developing rat hippocampus, release of GABA by coactive hilar interneurones generates widespread synchronized activity. Here it is shown that hilar interneurones strongly rectify in the outward direction when depolarized. This depolarization‐induced hyperpolarization, abolished by gap junction uncouplers, is modulated by nitric oxide. This phenomenon might represent a current‐shunting mechanism of the excess current by providing functional inhibition at a developmental stage when GABA is excitatory. Spatial buffering of the current might represent an osmotic mechanism for growth and differentiation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nitric oxide
KW  - depolarization induced hyperpolarization
KW  - gap junctions
KW  - brain development
KW  - rats
KW  - gamma aminobutyric acid
KW  - hippocampus
KW  - 1998
KW  - Depolarization
KW  - Hyperpolarization
KW  - Gap Junctions
KW  - Brain Development
KW  - Gamma Aminobutyric Acid
KW  - Hippocampus
KW  - Nitric Oxide
KW  - Rats
KW  - 1998
U1  - Sponsor: National Research Council. Grant: 95.01664.CT04. Recipients: No recipient indicated
DO  - 10.1046/j.1460-9568.1998.00047.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13194-043&site=ehost-live&scope=site
UR  - Fabrizio-strata@vanderbilt.edu
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1997-38801-001
AN  - 1997-38801-001
AU  - Moody, Sohie Lee
AU  - Wise, Steven P.
AU  - di Pellegrino, Giuseppe
AU  - Zipser, David
T1  - A model that accounts for activity in primate frontal cortex during a delayed matching-to-sample task.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/01//
VL  - 18
IS  - 1
SP  - 399
EP  - 410
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
N1  - Accession Number: 1997-38801-001. PMID: 9412516 Partial author list: First Author & Affiliation: Moody, Sohie Lee; National Institute of Mental Health, Lab of Systems Neuroscience, Poolesville, MD, US. Release Date: 19980401. Correction Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Matching to Sample; Motor Cortex; Neural Networks; Neurons; Prefrontal Cortex. Minor Descriptor: Monkeys. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study. Page Count: 12. Issue Publication Date: Jan, 1998. 
AB  - A fully recurrent neural network model was optimized to perform a spatial delayed matching-to-sample task. The model, although not constrained to do so, worked by using 2 corresponding classes of neurons in the hidden layer: storage and comparator units. Both unit types were tuned directionally. These 2 sources of information combine to create unique patterns of activity that determine whether a match has occurred. In networks with abundant hidden units, the storage and comparator functions were distributed so that individual units took part in both. The authors compared the model with single-neuron recordings from the premotor (PM) and prefrontal (PF) cortex. As shown previously (G. di Pelligrino and S. P. Wise, 1993), many PM and PF neurons behaved like storage units. In addition, both regions contain neurons that behave like the comparator units of the model and appear to have dual functionality similar to that observed in the model units. No neuron in either area had properties identical to those of the match output neuron of the model. However, 4 PF neurons and 1 PM neuron resembled the output signal more closely than any of the hidden units of the model. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neural network model with storage & comparator units vs single-neuron recordings from premotor & prefrontal cortex
KW  - performance of spatial delayed matching-to-sample task
KW  - monkeys
KW  - 1998
KW  - Matching to Sample
KW  - Motor Cortex
KW  - Neural Networks
KW  - Neurons
KW  - Prefrontal Cortex
KW  - Monkeys
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-38801-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - D'Souza, Rena N.
AU  - Cavender, Adriana
AU  - Dickinson, Douglas
AU  - Roberts, Anita
AU  - Letterio, John
T1  - TGF-β1 is essential for the homeostasis of the dentin-pulp complex.
JO  - European Journal of Oral Sciences
JF  - European Journal of Oral Sciences
Y1  - 1998/01/02/Jan1998 Supplement
VL  - 106
M3  - Article
SP  - 185
EP  - 191
SN  - 09098836
AB  - Among the complex network of cytokines that influence odontoblast function during development and repair, TGF-β1 is unique in its dual abilities to function as a potent immunosuppressant and as an inducer of extracellular matrix production. These properties underscore the importance of this molecule in maintaining the homeostasis of the dentin-pulp complex after injury. The purpose of this paper is to describe new findings of our phenotypic analysis of dentition in mice in which the TGF-β1 gene has been disrupted. The major phenotype of TGF-β1 (−/−) offspring is one of diffuse immune system activation with progressive inflammation, wasting and death. Our studies of adult TGF-β1 (−/−) dentition show widespread pulpal and periapical inflammation and necroses. In addition, the coronal surfaces of occluding molars show marked attrition. To determine whether the phenotypic changes in TGF-β1 (−/−) dentition are directly linked to the loss of TGF-β1 rather than the inflammatory process itself, we studied adult dentition in TGF-β1 (−/−) mice backcrossed into immunodeficient backgrounds. Results of our histopathologic and radiographic analyses show that teeth of TGF-β1 (−/−) immunodeficient mice retain vitality in pulpal and periapical regions but show excessive wear of occlusal surfaces. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Oral Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENTIN
KW  - DENTAL pulp
KW  - HOMEOSTASIS
KW  - TRANSFORMING growth factors-beta
KW  - INFLAMMATION
KW  - BIOMINERALIZATION
KW  - MICE as laboratory animals
KW  - DENTITION (Tooth development)
KW  - dentin
KW  - inflammation
KW  - mineralization
KW  - pulp
KW  - transforming growth factor beta
N1  - Accession Number: 99321314; D'Souza, Rena N. 1 Cavender, Adriana 1 Dickinson, Douglas 1 Roberts, Anita 1,2 Letterio, John 1,2; Affiliation:  1: Department of Basic Sciences, University of Texas Houston Health Science Center, Dental Branch, Houston, TX  2: Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Source Info: Jan1998 Supplement, Vol. 106, p185; Subject Term: DENTIN; Subject Term: DENTAL pulp; Subject Term: HOMEOSTASIS; Subject Term: TRANSFORMING growth factors-beta; Subject Term: INFLAMMATION; Subject Term: BIOMINERALIZATION; Subject Term: MICE as laboratory animals; Subject Term: DENTITION (Tooth development); Author-Supplied Keyword: dentin; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: mineralization; Author-Supplied Keyword: pulp; Author-Supplied Keyword: transforming growth factor beta; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3  - 10.1111/j.1600-0722.1998.tb02174.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=99321314&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Robert, B. Nussenblatt
AU  - bron, Anthony
AU  - Chambers, Wiley
AU  - James, P. McCulley
AU  - Pericoi, Marc
AU  - John, L. Ubels
AU  - Henry, F. Edelhauser
T1  - Ophthalmologic Perspectives on Eye Irritation Testing.
JO  - Journal of Toxicology -- Cutaneous & Ocular Toxicology
JF  - Journal of Toxicology -- Cutaneous & Ocular Toxicology
Y1  - 1998/01/02/
VL  - 17
IS  - 2/3
M3  - Article
SP  - 103
EP  - 109
SN  - 07313829
N1  - Accession Number: 78466773; Robert, B. Nussenblatt 1; bron, Anthony 2; Chambers, Wiley 3; James, P. McCulley 4; Pericoi, Marc 5; John, L. Ubels 6; Henry, F. Edelhauser 7; Affiliations: 1: National Eye Institute National Institutes of Health, Bethesda, Maryland; 2: Nuffield Laboratory of Ophthalmology Oxford, United Kingdom; 3: U.S. Food and Drug Administration, Washington, D.C.; 4: University of Texas Southwestern Medical School Dallas, Texas; 5: Peritesco Paris, France; 6: Calvin College Grand Rapids, Michigan; 7: Emory University Atlanta, Georgia; Issue Info: 1998, Vol. 17 Issue 2/3, p103; Number of Pages: 7p; Document Type: Article
L3  - 10.3109/15569529809049311
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=78466773&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107298346
T1  - Asthma and food allergy... International Conference Series on Nutrition and Health Promotion. Conference on Nutrition and Immunity, Atlanta, Georgia, May 5-7, 1997.
AU  - Rumsaeng V
AU  - Metcalfe DD
Y1  - 1998/01/02/Jan98 Part 2 of 2
N1  - Accession Number: 107298346. Language: English. Entry Date: 19981201. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Supplement Title: Jan98 Part 2 of 2. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405. 
KW  - Asthma
KW  - Food Hypersensitivity
KW  - Antigens
KW  - Food Hypersensitivity -- Diagnosis
KW  - Asthma -- Etiology
SP  - S153
EP  - 60
JO  - Nutrition Reviews
JF  - Nutrition Reviews
JA  - NUTR REV
VL  - 56
IS  - 1
PB  - Oxford University Press / USA
SN  - 0029-6643
AD  - National Institute of Allergy and Infectious Diseases
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107298346&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107150309
T1  - Incidence and risk factors for self-reported peptic ulcer disease in the United States.
AU  - Everhart JE
AU  - Byrd-Holt D
AU  - Sonnenberg A
Y1  - 1998/01/06/
N1  - Accession Number: 107150309. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: NIH contracts N01-DK-1-2282 and N01-DK-6-2220. NLM UID: 7910653. 
KW  - Peptic Ulcer -- Epidemiology -- United States
KW  - Risk Factors
KW  - United States
KW  - Self Report
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Multiple Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Logistic Regression
KW  - Smoking
KW  - P-Value
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 529
EP  - 536
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 147
IS  - 6
PB  - Oxford University Press / USA
AB  - Incidence and risk factors for peptic ulcer disease in the United States have not been well defined. During the 1989 National Health Interview Survey, a population-based sample of 42,392 individuals responded to questions regarding doctor-diagnosed ulcers with confirmation by either an upper gastrointestinal series or endoscopy. Ulcers present during the previous 12 months were considered either incident ulcers if diagnosed during this period or chronic active ulcers if diagnosed more than 12 months before the interview. The incidence of ulcers over the year prior to the interview was 5.27 per 1,000 adults. Whereas incident duodenal ulcer cases represented only 2.4 percent of all persons with a history of duodenal ulcer, the corresponding value for gastric ulcer was 8.7 percent. Risk factors for incident ulcers included increasing age, lower income and educational attainment, and musculoskeletal pain or headache. These were similar to risk factors for chronic active ulcers, except smoking was an additional important risk factor for chronic active ulcers. Thus, incident peptic ulcers are common in the United States but represent a small proportion of persons with a history of ulcer disease. Smoking may be a stronger risk factor for chronic ulcers than for new ulcers.
SN  - 0002-9262
AD  - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Natcher Bldg, Room 6AN-12J, 45 Center Dr MSC 6600, Bethesda, MD 20892-6600
U2  - PMID: 9521179.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107150309&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Watanabe, Hideto
AU  - Yamada, Yoshihiko
AU  - Kimata, Koji
T1  - Roles of Aggrecan, a Large Chondroitin Sulfate Proteoglycan, in Cartilage Structure and Function.
JO  - Journal of Biochemistry
JF  - Journal of Biochemistry
Y1  - 1998/01/10/
VL  - 124
IS  - 4
M3  - Article
SP  - 687
EP  - 693
SN  - 0021924X
N1  - Accession Number: 82499768; Watanabe, Hideto 1 Yamada, Yoshihiko 1 Kimata, Koji 2; Affiliation:  1: Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health Bethesda MD 20892  2: Institute for Molecular Science of Medicine, Aichi Medical University Aichi 480–1195; Source Info: 1998, Vol. 124 Issue 4, p687; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105819744
T1  - Standardizing the expression and nomenclature of cancer treatment regimens. American Society of Health-System Pharmacist (ASHP), American Medical Association (AMA), American Nurses Association (ANA)
AU  - Kohler DR
AU  - Montello MJ
AU  - Green L
AU  - Huntley C
AU  - High JL
AU  - Fallavollita A Jr
AU  - Goldspiel BR
Y1  - 1998/01/15/1998 Jan 15
N1  - Accession Number: 105819744. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; practice guidelines. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023. 
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Drug Administration Schedule
KW  - Drug Labeling -- Standards
KW  - Nomenclature
KW  - Practice Guidelines
KW  - American Medical Association
KW  - American Nurses Association
KW  - Coding -- Standards
KW  - Education, Pharmacy -- Standards
KW  - Medication Errors
KW  - National Institutes of Health (U.S.)
KW  - Professional Organizations
KW  - United States
SP  - 137
EP  - 144
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
JA  - AM J HEALTH SYST PHARM AJHP
VL  - 55
IS  - 2
CY  - Bethesda, Maryland
PB  - American Society of Health System Pharmacists
AB  - Guidelines for describing cancer chemotherapy regimens in all aspects of drug development, including treatment protocols, order forms, and product labels, are proposed. To complement the approaches to reducing medication errors that have been recommended by ASHP and others, pharmacists at the National Institutes of Health and the National Cancer Institute, with the input of oncology pharmacists from diverse areas of practice, developed guidelines for expressing chemotherapy dosage schedules and treatment regimens. The guidelines present standards that are broadly applicable and can be adopted by other institutions. Clear and unambiguous expression of all medication orders and consistency of treatment descriptions are suggested. Written treatment plans and orders should contain enough information to allow health care providers from diverse disciplines to compare them with published treatment descriptions and investigational protocols and must therefore include planned dosages and schedules expressed in patient-specific units. In general, drug dosages should be expressed as the amount of drug administered from a single container. When ordering drugs that are part of complex or combination-drug regimens, prescribers should write as many of the orders at one time as is possible, so that continuity might be preserved. Standard rules are proposed for describing chemotherapy regimens.
SN  - 1079-2082
AD  - Pharmacy Department, Warren Grant Magnuson Clinical Center, National Institutes of Health (NIH), Bethesda, MD 20892-1196, USA.
U2  - PMID: 9465977.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105819744&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wong, Jiemin
AU  - Patterton, Danielle
AU  - Imhof, Axel
AU  - Guschin, Dmitry
AU  - Yun-Bo Shi
AU  - Wolffe, Alan P.
T1  - Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/01/15/
VL  - 17
IS  - 2
M3  - Article
SP  - 520
EP  - 534
SN  - 02614189
AB  - Histone deacetylase and chromatin assembly contribute to the control of transcription of the Xenopus TRA gene promoter by the heterodimer of Xenopus thyroid hormone receptor and 9-cis retinoic acid receptor (TR-RXR). Addition of the histone deacetylase inhibitor Trichostatin A (TSA) relieves repression of transcription due to chromatin assembly following microinjection of templates into Xenopus oocyte nuclei, and eliminates regulation of transcription by TR-RXR. Expression of Xenopus RPD3p, the catalytic subunit of histone deacetylase, represses the TRA promoter, but only after efficient assembly of the template into nucleosomes. In contrast, the unliganded TR-RXR represses templates only partially assembled into nucleosomes; addition of TSA also relieves this transcriptional repression. This result indicates the distinct requirements for chromatin assembly in mediating transcriptional repression by the deacetylase alone, compared with those needed in the presence of unliganded TR-RXR. In addition, whereas hormone-bound TR-RXR targets chromatin disruption as assayed through changes in minichromosome topology and loss of a regular nucleosomal ladder on micrococcal nuclease digestion, addition of TSA relieves transcriptional repression but does not disrupt chromatin. Thus, TR-RXR can facilitate transcriptional repression in the absence of hormone through mechanisms in addition to recruitment of deacetylase, and disrupts chromatin structure through mechanisms in addition to the inhibition or release of deacetylase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHROMATIN
KW  - GENETIC transcription -- Regulation
KW  - CHROMOSOME abnormalities
KW  - THYROID hormones
KW  - NUCLEAR receptors (Biochemistry)
KW  - TRANSCRIPTION factors
KW  - HISTONE deacetylase
KW  - ACETYLATION
KW  - chromatin disruption
KW  - histone acetylation
KW  - nuclear receptor
KW  - transcription factor acetylation
KW  - transcriptional control
N1  - Accession Number: 13005981; Wong, Jiemin 1 Patterton, Danielle 2 Imhof, Axel 2 Guschin, Dmitry 2 Yun-Bo Shi 1 Wolffe, Alan P. 2; Email Address: awlme@helix.nih.gov; Affiliation:  1: Unit on Molecular Morphogenesis, Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA  2: Section on Molecular Biology, Laboratory of Molecular Embryology, National Institutes of Health, Bethesda, MD, USA; Source Info: 1/15/98, Vol. 17 Issue 2, p520; Subject Term: CHROMATIN; Subject Term: GENETIC transcription -- Regulation; Subject Term: CHROMOSOME abnormalities; Subject Term: THYROID hormones; Subject Term: NUCLEAR receptors (Biochemistry); Subject Term: TRANSCRIPTION factors; Subject Term: HISTONE deacetylase; Subject Term: ACETYLATION; Author-Supplied Keyword: chromatin disruption; Author-Supplied Keyword: histone acetylation; Author-Supplied Keyword: nuclear receptor; Author-Supplied Keyword: transcription factor acetylation; Author-Supplied Keyword: transcriptional control; Number of Pages: 15p; Document Type: Article
L3  - 10.1093/emboj/17.2.520
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13005981&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ramsden, Dale A.
AU  - Gellert, Martin
T1  - Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/01/15/
VL  - 17
IS  - 2
M3  - Article
SP  - 609
EP  - 614
SN  - 02614189
AB  - Ku protein binds to DNA ends and is a cofactor for the DNA-dependent protein kinase. Both of these components are involved in DNA double-strand break repair, but it has not been clear if they function indirectly, by sensing DNA damage and activating other factors, or if they are more directly involved in the processing and rejoining of DNA breaks. We demonstrate that intermolecular ligation of DNA fragments is highly dependent on Ku under conditions designed to mimic those existing in the cell. This effect of Ku is specific to eukaryotic DNA ligases. Ku protein, therefore, has an activity consistent with a direct role in rejoining DNA breaks and independent of DNA-dependent protein kinase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA repair
KW  - DNA ligases
KW  - DNA damage
KW  - BIOCHEMICAL genetics
KW  - GENETIC recombination
KW  - PROTEIN binding
KW  - PROTEIN kinases
KW  - DNA-protein interactions
KW  - dna repair
KW  - dna-pk
KW  - ku70
KW  - ku86
KW  - v(d)j recombination
N1  - Accession Number: 13005973; Ramsden, Dale A. 1 Gellert, Martin 1; Email Address: gellert@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Biology, Building 5, Room 241, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: 1/15/98, Vol. 17 Issue 2, p609; Subject Term: DNA repair; Subject Term: DNA ligases; Subject Term: DNA damage; Subject Term: BIOCHEMICAL genetics; Subject Term: GENETIC recombination; Subject Term: PROTEIN binding; Subject Term: PROTEIN kinases; Subject Term: DNA-protein interactions; Author-Supplied Keyword: dna repair; Author-Supplied Keyword: dna-pk; Author-Supplied Keyword: ku70; Author-Supplied Keyword: ku86; Author-Supplied Keyword: v(d)j recombination; Number of Pages: 6p; Document Type: Article
L3  - 10.1093/emboj/17.2.609
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gordienko, Irina
AU  - Rupp, W. Dean
T1  - A specific 3' exonuclease activity of UvrABC.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/01/15/
VL  - 17
IS  - 2
M3  - Article
SP  - 626
EP  - 633
SN  - 02614189
AB  - Specific cutting of undamaged DNA by UvrABC nuclease is observed. It occurs seven nucleotides (nt) from the 3 terminus of oligonucleotides annealed to single-stranded M13 DNA circles. Although the location of the UvrABC cut on undamaged DNA is similar to that of the cut on the 5′ side of a damaged DNA site during the dual incision reaction, the cut of undamaged DNA is not an intermediate in the dual incision step. On DNA duplexes with a single AAF adduct, the anticipated cut at the eighth phosphodiester bond 5′ of the lesion is present, but extra cuts at 7-nt increments are observed at the 15th and 22nd phosphodiester bonds. We suggest that these additional cuts are made by the UvrABC activity observed on undamaged DNA; such activity is referred to as ABC 3′ exonuclease and may play a significant role by providing a suitable gap for RecA-mediated recombinational exchanges during repair of interstrand crosslinks and closely opposed lesions. This ABC 3′ exonuclease activity depends on higher concentrations of Uvr proteins as compared with dual incision and may be relevant to reactions that occur when UvrA and UvrB are increased during SOS induction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA repair
KW  - DNA damage
KW  - DNA ligases
KW  - DNA-protein interactions
KW  - BIOCHEMICAL genetics
KW  - PROTEINS
KW  - EXONUCLEASES
KW  - OLIGONUCLEOTIDES
KW  - dna repair
KW  - exonuclease
KW  - reca-mediated exchanges
KW  - side cut
KW  - sos response
KW  - uvrabc 3&prime
KW  - uvrabc 5&prime
N1  - Accession Number: 13005971; Gordienko, Irina 1,2 Rupp, W. Dean 1,3; Email Address: RppWD@maspo3.mas.yale.edu; Affiliation:  1: Yale University School of Medicine, Department of Therapeutic Radiology, 333 Cedar Street, PO Box 208040, New Haven, CT, USA  2: Laboratory of Moelcular Biology, National Institute of Mental Health, Building 36, Room 1B08, 36 Convent Drive Bethesda, MD, USA  3: Yale University School of Medicine, Department of Molecular Biophysics and Biochemistry, 333 Cedar Street, PO Box 208040, New Haven, CT, USA; Source Info: 1/15/98, Vol. 17 Issue 2, p626; Subject Term: DNA repair; Subject Term: DNA damage; Subject Term: DNA ligases; Subject Term: DNA-protein interactions; Subject Term: BIOCHEMICAL genetics; Subject Term: PROTEINS; Subject Term: EXONUCLEASES; Subject Term: OLIGONUCLEOTIDES; Author-Supplied Keyword: dna repair; Author-Supplied Keyword: exonuclease; Author-Supplied Keyword: reca-mediated exchanges; Author-Supplied Keyword: side cut; Author-Supplied Keyword: sos response; Author-Supplied Keyword: uvrabc 3&prime; Author-Supplied Keyword: uvrabc 5&prime; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 8p; Document Type: Article
L3  - 10.1093/emboj/17.2.626
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107147643
T1  - Relation of self-image to body size and weight loss attempts in black women: the CARDIA Study.
AU  - Riley NM
AU  - Bild DE
AU  - Cooper L
AU  - Schreiner P
AU  - Smith DE
AU  - Sorlie P
AU  - Thompson JK
Y1  - 1998/01/21/
N1  - Accession Number: 107147643. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: Figure Rating Scale; Body Image Satisfaction (BIS); Appearance Evaluation Subscale (AES); Multidimensional Body-Self Relations Questionnaire. Grant Information: National Heart, Lung, and Blood Institute under a pre-IRTA [Intramural Research Training Award] Fellowship (No. TP-HL-1000). NLM UID: 7910653. 
KW  - Blacks
KW  - Body Image
KW  - Body Constitution
KW  - Weight Control
KW  - Self Concept
KW  - Funding Source
KW  - P-Value
KW  - Research Instruments
KW  - Questionnaires
KW  - Multiple Logistic Regression
KW  - Logistic Regression
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Spearman's Rank Correlation Coefficient
KW  - Age Factors
KW  - Odds Ratio
KW  - Descriptive Statistics
KW  - Adult
KW  - Female
KW  - Human
SP  - 1062
EP  - 1068
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 148
IS  - 11
PB  - Oxford University Press / USA
AB  - It has been suggested that the prevalence of obesity in black women is high partly because self-image in black women is not strongly dependent on body size. To determine associations between self-image, body size, and dieting behavior among black women, the authors assessed an Appearance Evaluation Subscale (AES) score (range, 1-5), a Body Image Satisfaction (BIS) score (range, 2-11), and reported dieting behavior in a population-based sample of 1,143 black women aged 24-42 years from the fourth follow-up examination (1992-1993) of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Lower AES and BIS scores indicate poorer self-image and lower body size satisfaction, respectively. After adjustment for age, education, smoking, and physical activity, women in the lowest, middle, and highest tertiles of body mass index (weight (kg)/height (m)2) had mean AES scores of 3.7, 3.3, and 2.9, respectively (p < 0.001), and mean BIS scores of 7.8, 6.7, and 5.9, respectively (p < 0.001). After additional control for body mass index as a continuous variable, both AES and BIS scores were inversely related to ever dieting, current dieting, and previous weight loss of 10 pounds (4.5 kg) or more in all tertiles of body mass index. These results suggest that among black women, a higher body mass index is associated with poorer self-image and lower body size satisfaction and that these perceptions may be an avenue to promoting weight control.
SN  - 0002-9262
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD
U2  - PMID: 9850128.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107253955
T1  - Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome.
AU  - Schmidt PJ
AU  - Nieman LK
AU  - Danaceau MA
AU  - Adams LF
AU  - Rubinow DR
Y1  - 1998/01/22/
N1  - Accession Number: 107253955. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Beck Depression Inventory (BDI); Rating Scale for Premenstrual Tension Syndrome; Spielberger Anxiety Inventory-State Form; Daily Rating Form. NLM UID: 0255562. 
KW  - Premenstrual Syndrome -- Physiopathology
KW  - Estradiol -- Pharmacodynamics
KW  - Progesterone -- Pharmacodynamics
KW  - Leuprolide -- Pharmacodynamics
KW  - Premenstrual Syndrome -- Symptoms
KW  - Emotions -- Drug Effects
KW  - Double-Blind Studies
KW  - Premenstrual Syndrome -- Psychosocial Factors
KW  - Premenstrual Syndrome -- Drug Therapy
KW  - Leuprolide -- Therapeutic Use
KW  - Leuprolide -- Adverse Effects
KW  - Estradiol -- Physiology
KW  - Progesterone -- Physiology
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Psychological Tests
KW  - Visual Analog Scaling
KW  - Human
SP  - 209
EP  - 216
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 338
IS  - 4
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institute of Mental Health, Bldg. 10, Rm. 3N238, 10 Center Dr. MSC 1276, Bethesda, MD 20892-1276
U2  - PMID: 9435325.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Strickler, Howard D.
AU  - Rosenberg, Philip S.
AU  - Devesa, Susan S.
AU  - Hertel, Joan
AU  - Fraumeni, Joseph F.
AU  - Goedert, James J.
AU  - Strickler, H D
AU  - Rosenberg, P S
AU  - Devesa, S S
AU  - Hertel, J
AU  - Fraumeni, J F Jr
AU  - Goedert, J J
T1  - Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1998/01/28/
VL  - 279
IS  - 4
M3  - journal article
SP  - 292
EP  - 295
SN  - 00987484
AB  - <bold>Context: </bold>Poliovirus vaccine contaminated with live simian virus 40 (SV40), a macaque polyomavirus that is tumorigenic in rodents, was used extensively in the United States between 1955 and 1963. Simian virus 40 DNA has recently been detected in several rare human tumors, including ependymomas, osteosarcomas, and mesotheliomas.<bold>Objective: </bold>To determine the risk of ependymoma, osteosarcoma, and mesothelioma among Americans who as children received SV40-contaminated poliovirus vaccine.<bold>Design: </bold>Retrospective cohort study using data from the Surveillance, Epidemiology, and End Results program (1973-1993) and the Connecticut Tumor Registry (1950-1969), as well as national mortality statistics (1947-1973).<bold>Setting: </bold>United States.<bold>Participants: </bold>Birth cohorts that were likely to have received SV40-contaminated poliovirus vaccine as infants, born 1956 through 1962 (60 811730 person-years of observation); as children, born 1947 through 1952 (46430953 person-years); or that were unexposed, born 1964 through 1969 (44959979 person-years).<bold>Main Outcome Measures: </bold>Relative risk (RR) of each cancer among exposed compared with unexposed birth cohorts.<bold>Results: </bold>Age-specific cancer rates were generally low and were not significantly elevated in birth cohorts exposed to SV40-contaminated vaccine. Specifically, compared with the unexposed, the relative risk of ependymoma was not increased in the cohorts exposed as infants (RR, 1.06; 95% confidence interval [CI], 0.69-1.63), or as children (RR, 0.98; 95% CI, 0.57-1.69) nor did the exposed have an increased risk of all brain cancers. Osteosarcoma incidence also showed no relation to exposure as infants (RR, 0.87; 95% CI, 0.71-1.06) or children (RR, 0.85; 95% CI, 0.59-1.22). Last, mesotheliomas were not significantly associated with exposure, although the cohorts studied have not yet reached the age at which these tumors tend to occur.<bold>Conclusions: </bold>After more than 30 years of follow-up, exposure to SV40-contaminated poliovirus vaccine was not associated with significantly increased rates of ependymomas and other brain cancers, osteosarcomas, or mesotheliomas in the United States. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POLIOVIRUS
KW  - VACCINES
KW  - SIMIAN viruses
KW  - UNITED States
N1  - Accession Number: 176806; Strickler, Howard D. Rosenberg, Philip S. Devesa, Susan S. Hertel, Joan Fraumeni, Joseph F. Goedert, James J. Strickler, H D 1 Rosenberg, P S Devesa, S S Hertel, J Fraumeni, J F Jr Goedert, J J; Affiliation:  1: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Md 20852, USA; Source Info: 1/28/98, Vol. 279 Issue 4, p292; Subject Term: POLIOVIRUS; Subject Term: VACCINES; Subject Term: SIMIAN viruses; Subject Term: UNITED States; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 5 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107259235
T1  - Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials.
AU  - Ioannidis JPA
AU  - Ioannidis, J P
Y1  - 1998/01/28/
N1  - Accession Number: 107259235. Language: English. Entry Date: 19980401. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Statistical Significance
KW  - Clinical Trials
KW  - Publishing
KW  - Bias (Research)
KW  - Time Factors
KW  - Kaplan-Meier Estimator
KW  - Cox Proportional Hazards Model
KW  - HIV Infections -- Drug Therapy
KW  - Human
SP  - 281
EP  - 286
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 279
IS  - 4
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Medical evidence may be biased over time if completion and publication of randomized efficacy trials are delayed when results are not statistically significant.Objective: To evaluate whether the time to completion and the time to publication of randomized phase 2 and phase 3 trials are affected by the statistical significance of results and to describe the natural history of such trials.Design: Prospective cohort of randomized efficacy trials conducted by 2 trialist groups from 1986 to 1996.Setting: Multicenter trial groups in human immunodeficiency virus infection sponsored by the National Institutes of Health.Patients: A total of 109 efficacy trials (total enrollment, 43708 patients).Main Outcome Measures: Time from start of enrollment to completion of follow-up and time from completion of follow-up to peer-reviewed publication assessed with survival analysis.Results: The median time from start of enrollment to publication was 5.5 years and was substantially longer for negative trials than for results favoring an experimental arm (6.5 vs 4.3 years, respectively; P<.001; hazard ratio for time to publication for positive vs negative trials, 3.7; 95% confidence interval [CI], 1.8-7.7). This difference was mostly attributable to differences in the time from completion to publication (median, 3.0 vs 1.7 years for negative vs positive trials; P<.001). On average, trials with significant results favoring any arm completed follow-up slightly earlier than trials with nonsignificant results (median, 2.3 vs 2.5 years; P=.045), but long-protracted trials often had low event rates and failed to reach statistical significance, while trials that were terminated early had significant results. Positive trials were submitted for publication significantly more rapidly after completion than were negative trials (median, 1.0 vs 1.6 years; P=.001) and were published more rapidly after submission (median, 0.8 vs 1.1 years; P=.04).Conclusion: Among randomized efficacy trials, there is a time lag in the publication of negative findings that occurs mostly after the completion of the trial follow-up.
SN  - 0098-7484
AD  - HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20892, USA
AD  - HIV Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Bldg 2C31, 6003 Executive Blvd, Bethesda, MD 20892; e-mail: ji24m@nih.gov
U2  - PMID: 9450711.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107281335
T1  - Pain as a complication of HIV disease.
AU  - Hirschfeld S
Y1  - 1998/02//
N1  - Accession Number: 107281335. Language: English. Entry Date: 20050507. Revision Date: 20150818. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225. 
KW  - HIV Infections -- Complications
KW  - Pain
KW  - Pain Measurement
KW  - Research
KW  - Analgesics, Opioid -- Pharmacodynamics
KW  - Pain -- Physiopathology
KW  - Pain -- Etiology
KW  - Pain -- Drug Therapy
KW  - Pain -- Chemically Induced
KW  - Pain -- Epidemiology
KW  - Antiviral Agents -- Adverse Effects
KW  - AIDS Patients
SP  - 91
EP  - 108
JO  - AIDS Patient Care & STDs
JF  - AIDS Patient Care & STDs
JA  - AIDS PATIENT CARE STDS
VL  - 12
IS  - 2
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1087-2914
AD  - National Cancer Institute, Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 11361928.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Cotch, Mary Frances
AU  - Hillier, Sharon L.
AU  - Gibbs, Ronald S.
AU  - Eschenbach, David A.
AU  - Cotch, M F
AU  - Hillier, S L
AU  - Gibbs, R S
AU  - Eschenbach, D A
T1  - Epidemiology and outcomes associated with moderate to heavy Candida colonization during pregnancy. Vaginal Infections and Prematurity Study Group.
JO  - American Journal of Obstetrics & Gynecology
JF  - American Journal of Obstetrics & Gynecology
Y1  - 1998/02//
VL  - 178
IS  - 2
M3  - journal article
SP  - 374
EP  - 380
SN  - 00029378
AB  - <bold>Objective: </bold>Our purpose was to determine the risk factors, physical findings, microflora, and pregnancy outcome among pregnant women with moderate to heavy vaginal growth of Candida albicans and other Candida species.<bold>Study Design: </bold>A multicenter cohort of 13,914 women were enrolled between 23 and 26 weeks' gestation. Women completed a questionnaire, underwent a physical examination, and had genital specimens taken for culture. A subset of 1459 women were reexamined during the third trimester. Pregnancy outcomes were recorded at delivery.<bold>Results: </bold>The prevalence of moderate to heavy Candida colonization at midgestation was 10%. Colonized women, 83% of whom carried C. albicans, were more likely to be black or Hispanic, unmarried, a previous oral contraceptive user, and to manifest clinical signs indicative of Candida carriage. Candida colonization was positively associated with Trichomonas vaginalis, group B streptococci, and aerobic Lactobacillus and was not associated with adverse pregnancy outcome.<bold>Conclusion: </bold>These results suggest that Candida colonization is not associated with low birth weight or preterm delivery. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANCY complications
KW  - CANDIDA albicans
N1  - Accession Number: 336357; Cotch, Mary Frances; Hillier, Sharon L.; Gibbs, Ronald S.; Eschenbach, David A.; Cotch, M F 1; Hillier, S L; Gibbs, R S; Eschenbach, D A; Source Information: Feb98, Vol. 178 Issue 2, p374; Subject: PREGNANCY complications; Subject: CANDIDA albicans; Number of Pages: 7p; Illustrations: 4 Charts, 3 Graphs; Document Type: journal article
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DB  - hch
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Kuhn, Heather E.
AU  - Suomi, Stephen J.
T1  - Effects of upright posture on hand preference for reaching vs. the use of probing tools by tufted capuchins (Cebus apella ).
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1998/02//
VL  - 44
IS  - 2
M3  - Article
SP  - 147
EP  - 153
SN  - 02752565
AB  - This research examined the effects of task (reaching vs. Tool use) and posture (quadrupedal vs. bipedal) on hand preference in tufted capuchins (Cebus apella ). Regarding direction of hand preference, we found a significant main effect of posture, as the bipedal stance elicited greater use of the right hand than did the quadrupedal stance, and a significant posture × task interaction, as bipedal reaching elicited greater use of the right hand than did other postural and task conditions. Further, we found a significant main effect of task on strength of hand preference, as tool use elicited more consistent use of one hand over the other than did reaching. Our findings indicate that bipedal reaching facilitates a mild right-hand bias in intensely manipulative primates. We speculate that this moderate bias may have been pushed in the direction of nearly exclusive right-hand preference in most humans with the development of complex tool use. Am. J. Primatol. 44:147–153, 1998. © 1998 Wiley-Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - POSTURE
KW  - HAND
KW  - CAPUCHIN monkeys
KW  - MONKEYS
N1  - Accession Number: 12214662; Westergaard, Gregory Charles 1; Email Address: westergg@lce.nichd.nih.gov Kuhn, Heather E. 1 Suomi, Stephen J. 1; Affiliation:  1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development; Source Info: Feb98, Vol. 44 Issue 2, p147; Subject Term: POSTURE; Subject Term: HAND; Subject Term: CAPUCHIN monkeys; Subject Term: MONKEYS; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Goldenberg, Robert L.
AU  - Iams, Jay D.
AU  - Mercer, Brian M.
AU  - Meis, Paul J.
AU  - Moawad, Atef H.
AU  - Cooper, Rachel L.
AU  - Das, Anita
AU  - Thom, Elizabeth
AU  - Johnson, Francee
AU  - McNellis, Donald
AU  - Miodovnik, Menachem
AU  - Van Dorsten, J. Peter
AU  - Caritis, Steve N.
AU  - Thurnau, Gary R.
AU  - Bottoms, Sidney F.
T1  - The preterm prediction study: The value of new vs standard risk factors in predicting early and all spontaneous preterm births.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/02//
VL  - 88
IS  - 2
M3  - Article
SP  - 233
EP  - 238
PB  - American Public Health Association
SN  - 00900036
AB  - Objective. This study was undertaken to determine the relationship between fetal fibronectin, short cervix, bacterial vaginosis, other traditional risk factors, and spontaneous preterm birth. Methods. From 1992 through 1994, 2929 women were screened at the gestational age of 22 to 24 weeks. Results. The odds ratios for spontaneous preterm birth were highest for fetal fibronectin, followed by a short cervix and history of preterm birth. These factors, as well as bacterial vaginosis, were more strongly associated with early than with late spontaneous preterm birth. Bacterial vaginosis was more common--and a stronger predictor of spontaneous preterm birth--in Black women, while body mass index less than 19.8 was a stronger predictor in non-Black women. This analysis suggests a pathway leading from Black race through bacterial vaginosis and fetal fibronectin to spontaneous preterm birth. Prior preterm birth is associated with spontaneous preterm birth through a short cervix. Conclusions. Fetal fibronectin and a short cervix are stronger predictors of spontaneous preterm birth than traditional risk factors. Bacterial vaginosis was found more often in Black than in non-Black women and accounted for 40% of the attributable risk for spontaneous preterm birth at less than 32 weeks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREMATURE labor
KW  - PREMATURE infants
KW  - LABOR (Obstetrics)
KW  - CHILDBIRTH
KW  - PREGNANCY
N1  - Accession Number: 450459; Goldenberg, Robert L. 1 Iams, Jay D. 2 Mercer, Brian M. 3 Meis, Paul J. 4 Moawad, Atef H. 5 Cooper, Rachel L. 1 Das, Anita 6 Thom, Elizabeth 6 Johnson, Francee 2 McNellis, Donald 7 Miodovnik, Menachem 8 Van Dorsten, J. Peter 9 Caritis, Steve N. 10 Thurnau, Gary R. 11 Bottoms, Sidney F.; Affiliation:  1: University of Alabama, Birmingham  2: Ohio State University, Columbus  3: University of Tennessee, Memphis  4: Bowman Gray School of Medicine, Winston-Salem, NC  5: University of Chicago, Chicago, Ill.  6: George Washington University: The Biostatistics Center, Rockville, Md.  7: National Institute of Child Health and Human Development (NICHD), Bethesda, Md.  8: University of Cincinnati, Cincinnati, Ohio  9: Medical University of South Carolina, Charleston  10: Magee Women's Hospital, Pittsburgh, Pa.  11: University of Oklahoma, Oklahoma City; Source Info: Feb1998, Vol. 88 Issue 2, p233; Subject Term: PREMATURE labor; Subject Term: PREMATURE infants; Subject Term: LABOR (Obstetrics); Subject Term: CHILDBIRTH; Subject Term: PREGNANCY; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 5291
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DB  - aph
ER  - 

TY  - JOUR
ID  - 107265911
T1  - Association of insulin levels with lipids and lipoproteins in elderly Japanese-American men.
AU  - Burchfiel CM
AU  - Abbott RD
AU  - Curb JD
AU  - Sharp DS
AU  - Rodriguez BL
AU  - Arakaki R
AU  - Yano K
Y1  - 1998/02//1998 Feb
N1  - Accession Number: 107265911. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Contract NO1-HC-05102 from the National Heart, Lung, and Blood Institute, Bethesda, MD. NLM UID: 9100013. 
KW  - Insulin
KW  - Triglycerides
KW  - Lipoproteins, HDL Cholesterol
KW  - Cardiovascular Risk Factors
KW  - Obesity
KW  - Asians -- United States
KW  - United States
KW  - Hawaii
KW  - Cross Sectional Studies
KW  - Multiple Linear Regression
KW  - Analysis of Covariance
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 92
EP  - 98
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 8
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: Elevated insulin levels have been associated with cardiovascular disease, but the relationship of insulin with other risk factors and its position in the atherosclerotic pathway is uncertain. A cross-sectional study was conducted to determine whether insulin concentrations were associated with lipids and lipoproteins independently of adiposity and other cardiovascular risk factors. METHODS: Subjects included 3417 Japanese-American men from the Honolulu Heart Program who completed a follow-up examination between 1991 and 1993 and were 71-93 years of age. Men were categorized by quintiles of fasting and 2-hour insulin concentration. RESULTS: Age-adjusted mean high-density lipoprotein (HDL) cholesterol and triglyceride levels varied significantly across quintiles of fasting and 2-hour insulin (P < 0.001, tests for trend), but insulin was not related to total cholesterol and low-density lipoprotein (LDL) cholesterol. HDL cholesterol decreased from 59.3 to 43.7 mg/dL and triglycerides increased from 95.6 to 175.8 mg/dL comparing lowest to highest quintiles of fasting insulin, respectively. These associations were slightly stronger in lean than obese subjects and in nondiabetic versus diabetic individuals particularly for 2-hour insulin levels. Multiple linear regression analysis adjusting for several adiposity measures separately (body mass index (BMI), subscapular skinfold thickness, waist circumference, and waist/hip ratio) and other cardiovascular risk factors attenuated associations slightly but they still remained statistically significant. Estimated differences in HDL cholesterol across extreme quintiles of fasting insulin were reduced slightly from 15.6 mg/dL with adjustment for age to 12.5 mg/dL with adjustment for age and BMI, and to 11.3 mg/dL with adjustment for age, BMI, and cardiovascular risk factors. CONCLUSIONS: Insulin concentration was strongly and independently associated with HDL cholesterol and triglycerides in this cohort of elderly Japanese-American men. Since this study was cross-sectional, further investigation is required to determine whether elevated insulin levels are causally related to dyslipidemia.
SN  - 1047-2797
AD  - Honolulu Epidemiology Research Unit, Epidemiology and Biometry Program, Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Honolulu, HI
U2  - PMID: 9491933.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265919
T1  - Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy.
AU  - Klebanoff MA
AU  - Levine RJ
AU  - Dersimonian R
AU  - Clemens JD
AU  - Wilkins DG
Y1  - 1998/02//1998 Feb
N1  - Accession Number: 107265919. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Pregnancy
KW  - Caffeine
KW  - Theophylline
KW  - Biological Markers
KW  - Caffeine -- Administration and Dosage
KW  - Caffeine -- Analysis
KW  - Chromatography
KW  - Blood Specimen Collection
KW  - Prospective Studies
KW  - Sampling Methods
KW  - Smoking
KW  - Pearson's Correlation Coefficient
KW  - Kappa Statistic
KW  - Analysis of Variance
KW  - Female
KW  - Human
SP  - 107
EP  - 111
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 8
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: Previous studies of maternal caffeine use and pregnancy outcome have relied on self-reported use. Even if these were perfectly accurate, inter-individual differences in caffeine metabolism result in a relatively weak correlation between caffeine intake and serum concentration. The purpose of this study was to determine whether the serum concentration of caffeine or its primary metabolite, paraxanthine, obtained at an unknown time during working hours, is useful to distinguish between pregnant women who report consuming small and large amounts of caffeine. METHODS: We selected from the Birmingham fetal growth study 60 women with normal pregnancy outcomes who reported consuming < or = 0.8 mg/kg/day of caffeine in a 24-hour dietary recall, 60 who consumed 0.81-2.5 mg/kg/day, 60 who consumed 2.51-5.0 mg/kg/day and 59 who consumed > or = 5.01 mg/kg/day. These women had serum drawn for storage during regular clinic hours on the same day as the recall interview. Caffeine and paraxanthine were measured in the stored serum using high performance liquid chromatography. RESULTS: The weighted kappa coefficient between strata of caffeine intake and quartiles of serum paraxanthine was 0.58 among smokers and 0.53 among nonsmokers, versus 0.44 and 0.51, respectively, for quartiles of serum caffeine. The Pearson correlation coefficient between intake and paraxanthine was 0.50 for smokers and 0.53 for nonsmokers, and 0.37 and 0.51, respectively, for serum caffeine. These values are comparable to the correlation between reported smoking and serum cotinine in pregnancy. CONCLUSIONS: The serum concentrations of paraxanthine, and to a lesser degree, caffeine are useful to distinguish between women with varying levels of caffeine intake.
SN  - 1047-2797
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, NIH, Bethesda, MD
U2  - PMID: 9491935.
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DB  - rzh
ER  - 

TY  - JOUR
ID  - 107249169
T1  - Programmed instruction: cancer genetics. The role of the nurse in cancer genetics.
AU  - Dimond E
AU  - Calzone K
AU  - Davis J
AU  - Jenkins J
Y1  - 1998/02//1998 Feb
N1  - Accession Number: 107249169. Language: English. Entry Date: 19980401. Revision Date: 20150820. Publication Type: Journal Article; case study; CEU; exam questions; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Oncologic Nursing
KW  - Genetics
KW  - Neoplastic Syndromes, Hereditary
KW  - Programmed Instruction
KW  - Education, Continuing (Credit)
KW  - Information Resources
KW  - Nursing Assessment
KW  - Advanced Nursing Practice
KW  - Family History
KW  - Counseling
KW  - Nursing Role
KW  - World Wide Web
KW  - Breast Neoplasms
KW  - Genes
KW  - Adult
KW  - Female
SP  - 57
EP  - 75
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 21
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0162-220X
AD  - National Naval Medical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 9494232.
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DB  - rzh
ER  - 

TY  - JOUR
ID  - 107197756
T1  - Effortful echolalia.
AU  - Hadano K
AU  - Nakamura H
AU  - Hamanaka T
Y1  - 1998/02//1998 Feb
N1  - Accession Number: 107197756. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 0100725. 
KW  - Speech Disorders -- Diagnosis
KW  - Speech Disorders -- Etiology
KW  - Cerebrovascular Disorders
KW  - Aphasia -- Diagnosis
KW  - Magnetic Resonance Imaging
KW  - Tomography, X-Ray Computed
KW  - Frontal Lobe -- Pathology
KW  - Neuropsychological Tests
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
SP  - 67
EP  - 82
JO  - Cortex: A Journal Devoted to the Study of the Nervous System & Behavior
JF  - Cortex: A Journal Devoted to the Study of the Nervous System & Behavior
JA  - CORTEX
VL  - 34
IS  - 1
PB  - Masson SPA
AB  - We report three cases of effortful echolalia in patients with cerebral infarction. The clinical picture of speech disturbance is associated with Type 1 Transcortical Motor Aphasia (TCMA, Goldstein, 1915). The patients always spoke nonfluently with loss of speech initiative, dysarthria, dysprosody, agrammatism, and increased effort and were unable to repeat sentences longer than those containing four or six words. In conversation, they first repeated a few words spoken to them, and then produced self initiated speech. The initial repetition as well as the subsequent self initiated speech, which were realized equally laboriously, can be regarded as mitigated echolalia (Pick, 1924). They were always aware of their own echolalia and tried to control it without effect. These cases demonstrate that neither the ability to repeat nor fluent speech are always necessary for echolalia. The possibility that a lesion in the left medial frontal lobe, including the supplementary motor area, plays an important role in effortful echolalia is discussed.
SN  - 0010-9452
AD  - Department of Psychogeriatrics, National Institute of Mental Health (NCNP), 1-7-3 Kohnodai, Ichikawa, Chiba, 272, Japan; e-mail: hadano@ncnp-k-go.jp
U2  - PMID: 9533994.
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ER  - 

TY  - JOUR
AU  - Ban, T. A.
AU  - Gaszner, P.
AU  - Aguglia, E.
AU  - Batista, R.
AU  - Castillo, A.
AU  - Lipcsey, A.
AU  - Macher, J. P.
AU  - Torres-Ruiz, A.
AU  - Vergara, L.
T1  - Clinical efficacy of reboxetine: a comparative study with desipramine, with methodological considerations.
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1998/02//Feb98 Supplement 1
VL  - 13
M3  - Article
SP  - S29
EP  - S39
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - The efficacy and tolerability of 4–8 mg reboxetine, a selective noradrenaline reuptake inhibitor (NARI) was verified in a 4-week, double-blind, placebo- and desipramine-controlled study in hospitalised patients with major depression. Two-hundred-and-fifty-eight patients were recruited and randomised to treatment with 4–8 mg reboxetine, 100–200 mg desipramine or placebo on a fixed, changing dosage regimen. The therapeutic response rate (<50% reduction in mean efficacy rating scale total scores) was significantly higher with reboxetine than with placebo (p <0·05). The onset of therapeutic effect [when mean efficacy rating scale total scores became significantly (p <0·05) lower (better) than placebo] was consistently earlier with reboxetine than desipramine. From the three adverse events encountered with significant (p <0·05) difference among the groups, dryness of mouth and blurred vision were reported more frequently with desipramine than with reboxetine and placebo, whereas urinary hesitancy was reported more frequently with reboxetine than placebo. No clinically significant changes were observed in laboratory parameters and vital signs. The mean scores on the CGI-Efficacy Index in the reboxetine group was significantly (p <0·05) higher (better) than in the desipramine and placebo groups. CODE-DD demonstrated the broadness of the DSM-III-R diagnosis of major depression and provided information for designing studies for the detection of the treatment responsive population of reboxetine. In conclusion, reboxetine administered for 4 weeks in the daily doses of 4–8 mg was effective and well tolerated in treating hospitalised patients with major depression. © 1998 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human Psychopharmacology: Clinical & Experimental is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIDEPRESSANTS
KW  - PSYCHIATRIC drugs
KW  - NORADRENALINE
KW  - MENTAL depression
KW  - PSYCHOPHARMACOLOGY
KW  - depression
KW  - desipramine
KW  - efficacy
KW  - methodology
KW  - noradrenaline reuptake inhibitor
KW  - reboxetine
KW  - tolerability
N1  - Accession Number: 11822938; Ban, T. A. 1 Gaszner, P. 2 Aguglia, E. 3 Batista, R. 4 Castillo, A. 5 Lipcsey, A. 6 Macher, J. P. 7 Torres-Ruiz, A. 8 Vergara, L. 4; Affiliation:  1: FMCP Ltd and Department of Psychiatry, Vanderbilt University, Nashville, USA  2: National Institute for Psychiatry and Neurology, Huvosvolgyi ut 116, H-1021 Budapest II, Hungary  3: Department of Psychiatry, University of Trieste, Trieste, Italy  4: National Psychiatric Hospital, Panama City, Panama  5: Biological Psychiatry Laboratory, National Institute of Mental Health, Lima, Peru  6: Department of Neurology and Psychiatry, St Johns Hospital, Budapest, Hungary  7: Rouffach Hospital Centre, Rouffach, France  8: Department of Psychiatry, National Institute of Neurology, Mexico City, Mexico; Source Info: Feb98 Supplement 1, Vol. 13, pS29; Subject Term: ANTIDEPRESSANTS; Subject Term: PSYCHIATRIC drugs; Subject Term: NORADRENALINE; Subject Term: MENTAL depression; Subject Term: PSYCHOPHARMACOLOGY; Author-Supplied Keyword: depression; Author-Supplied Keyword: desipramine; Author-Supplied Keyword: efficacy; Author-Supplied Keyword: methodology; Author-Supplied Keyword: noradrenaline reuptake inhibitor; Author-Supplied Keyword: reboxetine; Author-Supplied Keyword: tolerability; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schooler, Carmi
T1  - History, social structure and individualism.
JO  - International Journal of Comparative Sociology (Brill Academic Publishers)
JF  - International Journal of Comparative Sociology (Brill Academic Publishers)
Y1  - 1998/02//
VL  - 39
IS  - 1
M3  - Article
SP  - 32
SN  - 00207152
AB  - This paper explore how history and social structure affect individualism in Japan. It integrates a variety of cross-cultural studies comparing Japan with the West whose ethological approaches vary considerably. Its historically comparisons point to many parallels between Japan and the West and reveal similar links between economic development and individualism. Sociological surveys demonstrate that similar environmental conditions, particularly environmental complexity, have similar effects in the two settings and provide evidence of growth in individualism in Japan resulting from an increase in such complexity. Anthropological and developmental psychological studies demonstrate how material behaviors reproduce cultural norms about appropriate norms about appropriate levels of group interdependence and suggest that material behaviour is becomes more individualistic in Japan, most probably as a result of changing socio-environmental conditions. Reported findings on how the institutionalization of values such as individualism or interdependence lead to such values continued acceptance provide and indication of why the values embodied in cultures and social structures often seem to change more slowly than do values of individuals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Comparative Sociology (Brill Academic Publishers) is the property of Brill Academic Publishers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL structure
KW  - INDIVIDUALISM
KW  - SOCIAL history
KW  - SOCIAL psychology
KW  - CROSS-cultural studies
KW  - JAPAN
N1  - Accession Number: 528394; Schooler, Carmi 1; Affiliation:  1: Section on Socio-environmental Studies, National Institute of Mental Health, Bethesda, Maryland 20892, U.S.A.; Source Info: Feb98, Vol. 39 Issue 1, p32; Subject Term: SOCIAL structure; Subject Term: INDIVIDUALISM; Subject Term: SOCIAL history; Subject Term: SOCIAL psychology; Subject Term: CROSS-cultural studies; Subject Term: JAPAN; Number of Pages: 20p; Document Type: Article
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ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Kuhn, Heather E.
AU  - Babitz, Mindy A.
AU  - Suomi, Stephen J.
T1  - Aimed Throwing as a Means of Food Transfer Between Tufted Capuchins (Cebus apella ).
JO  - International Journal of Primatology
JF  - International Journal of Primatology
Y1  - 1998/02//
VL  - 19
IS  - 1
M3  - Article
SP  - 123
EP  - 131
PB  - Springer Science & Business Media B.V.
SN  - 01640291
AB  - We examined aimed throwing as a means of food transfer in tufted capuchins ( Cebus apella). We conducted this research in three phases. In Phase 1 we provided food to monkeys in one of two groups housed 1 m apart. We did not provide food to subjects in the second group. An observer recorded each instance in which a subject in the first group threw food toward one in the second group. In Phase 2 we provided a group of capuchins with food and noted each instance in which a subject threw food toward an empty cage. In Phase 3 we provided food simultaneously to two groups of capuchins and noted each instance of food-throwing between them. In Phase 1 subjects in one group threw food toward subjects in a second group, which, when provided the opportunity, did not throw food toward capuchins in the first group. Thrown food was either caught, retrieved, or lost on the test room floor. The rate of throwing decreased significantly when subjects were presented with an empty cage and when both groups of subjects were given food. We propose that psychological processes which underlie aimed throwing and food sharing came into existence through convergent evolution in large-brained, extractive foraging primates. We further speculate that although a well-developed system of exchange, based on contingent reciprocity, may occur among primates only in Homo,simpler transfer systems involving voluntary unidirectional passing of food from one individual to another appear to be more widespread among primates than previously thought and can be expressed in rather unusual circumstances such as those in this experiment. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Primatology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cebus apella
KW  - Capuchin
KW  - food-sharing
KW  - THROWING
N1  - Accession Number: 357664; Westergaard, Gregory Charles 1; Kuhn, Heather E. 2; Babitz, Mindy A. 3; Suomi, Stephen J. 2; Affiliations: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland. National Institutes of Health Animal Center, Poolesville, Maryland 20837; 2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland; 3: School of Psychology, University of St. Andrews, St. Andrews, Scotland; Issue Info: Feb98, Vol. 19 Issue 1, p123; Subject Term: Cebus apella; Author-Supplied Keyword: Capuchin; Author-Supplied Keyword: food-sharing; Author-Supplied Keyword: THROWING; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
ID  - 107192296
T1  - Release and extracellular transit of glycosylphosphatidylinositol proteins.
AU  - Miller JL
Y1  - 1998/02//1998 Feb
N1  - Accession Number: 107192296. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0375375. 
KW  - Lipids -- Metabolism
KW  - Carbohydrate Metabolism
KW  - Biological Transport
KW  - Cell Membrane -- Metabolism
SP  - 115
EP  - 123
JO  - Journal of Laboratory & Clinical Medicine
JF  - Journal of Laboratory & Clinical Medicine
JA  - J LAB CLIN MED
VL  - 131
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
SN  - 0022-2143
AD  - Laboratory of Chemical Biology, Building 10, Room 9N308, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 9488493.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Underwood, Barbara A.
AU  - Underwood, B A
T1  - From research to global reality: the micronutrient story.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1998/02//
VL  - 128
IS  - 2
M3  - journal article
SP  - 145
EP  - 151
SN  - 00223166
AB  - The professional life history of E. V. McCollum exemplifies how sound nutrition-related laboratory research was translated into practical realities that influenced individual and national nutrition-related decisions. Public health and educational programs emerging in the first third of this century improved health and nutritional well-being in the United States. Characteristics that surrounded pioneering efforts early in the century are similar to those that have reinvigorated global micronutrient concerns in the last third of the century. Sound community-oriented scientific research revealed the true consequences of iodine, vitamin A and iron micronutrient malnutrition. Repositioning the image of these three micronutrients from that of a clinical problem affecting relatively few to one with consequences for individual, national and global development affecting many more, and disseminating these facts through high-level political forums incited attention, commitment and actions. As in the early days of McCollum and his contemporaries, current nutrition scientists played a significant role, interacting with politically oriented counterparts, in taking micronutrient research to reality for improving health and quality of life globally. Lessons learned from the process, both past and present, should guide future nutrition-oriented endeavours in moving research to reality for betterment of global community health. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUTRITION research
KW  - MCCOLLUM, E. V.
N1  - Accession Number: 235976; Underwood, Barbara A. Underwood, B A 1; Affiliation:  1: National Eye Institute, National Institutes of Health, Bethesda, MD 20814, USA; Source Info: Feb98, Vol. 128 Issue 2, p145; Subject Term: NUTRITION research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: MCCOLLUM, E. V.; Number of Pages: 7p; Illustrations: 3 Diagrams, 2 Charts; Document Type: journal article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Kitamura, Toshinori
AU  - Aoki, Mitsuka
AU  - Fujino, Masako
AU  - Ura, Chiaki
AU  - Watanabe, Mayumi
AU  - Watanabe, Kyoko
AU  - Fujihara, Shigeki
T1  - Sex Differences in Marital and Social Adjustment.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1998/02//
VL  - 138
IS  - 1
M3  - Article
SP  - 26
EP  - 32
PB  - Taylor & Francis Ltd
SN  - 00224545
AB  - The article examines the relationship of marital adjustment and social adjustment. A sample of 67 married Japanese men and 79 married Japanese women were interviewed to clarify the relationship between marital adjustment and social adjustment. For the whole sample the total score of the Short Marital Adjustment Test and its subcategories, dyadic consensus and satisfaction, was significantly correlated with 5 subcategory scores of the Social Adjustment Scale-lI: household adjustment (except the spouse), external family adjustment, work adjustment, social leisure adjustment, and general adjustment. These correlations were present also for the women: for the men, they were present only for social leisure adjustment and general adjustment. Among men, the dyadic consensus scores of the SMAT had stronger correlations with the social adjustment scores: among women, correlations with the marital satisfaction scores of the SMAT were stronger. Thus, marital adjustment may be a part of social adjustment for women, but the two may be discrete for men.
KW  - SOCIAL adjustment
KW  - SOCIAL psychology
KW  - GENDER differences (Psychology)
KW  - ADJUSTMENT (Psychology)
KW  - SELF-realization
KW  - SOCIAL skills
N1  - Accession Number: 368585; Kitamura, Toshinori 1 Aoki, Mitsuka 2 Fujino, Masako 2 Ura, Chiaki 3 Watanabe, Mayumi 2 Watanabe, Kyoko 2 Fujihara, Shigeki 4; Affiliation:  1: Department of Socioenvironmental Research, National Institute of Mental Health, Ichikawa, Japan  2: Department of School Education, Yokohama National University, Yokohama, Japan  3: Faculty of Psychology, Tokyo Gakugei University, Tokyo, Japan  4: Yamanashi Prefectural Mental Health Centre, Kofu, Japan; Source Info: Feb1998, Vol. 138 Issue 1, p26; Subject Term: SOCIAL adjustment; Subject Term: SOCIAL psychology; Subject Term: GENDER differences (Psychology); Subject Term: ADJUSTMENT (Psychology); Subject Term: SELF-realization; Subject Term: SOCIAL skills; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 2532
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107260455
T1  - Assessing the need for anesthesia and sedation in the general population.
AU  - Dionne RA
AU  - Gordon SM
AU  - McCullagh LM
AU  - Phero JC
Y1  - 1998/02//
N1  - Accession Number: 107260455. Language: English. Entry Date: 19980501. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by a grant from the Anesthesia Research Foundation of the American Dental Society of Anesthesiology, Chicago, IL. NLM UID: 7503060. 
KW  - Dental Anxiety -- Epidemiology
KW  - Anesthesia, General
KW  - Conscious Sedation
KW  - Antianxiety Agents -- Therapeutic Use
KW  - Dental Anxiety -- Prevention and Control
KW  - Dental Care -- Psychosocial Factors
KW  - Health Services Needs and Demand
KW  - Pain -- Prevention and Control
KW  - Telephone
KW  - Surveys
KW  - Stratified Random Sample
KW  - Interviews
KW  - Data Analysis Software
KW  - Descriptive Statistics
KW  - Pearson's Correlation Coefficient
KW  - P-Value
KW  - Education, Continuing (Credit)
KW  - Funding Source
KW  - Human
SP  - 167
EP  - 233
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 129
IS  - 2
CY  - Chicago, Illinois
PB  - American Dental Association
AB  - The authors used a national telephone survey to examine the relationship between dental anxiety and the use of pain and anxiety control measures in the general population. Nearly 30 percent of respondents reported being somewhat nervous, very nervous or terrified about going to the dentist. There was a threefold difference between the reported use of anesthesia and sedation and respondents' preference for these treatment modalities. These data suggest that fear of dentistry is still prevalent and that patients who are fearful would seek oral health care more regularly if general anesthesia or conscious sedation were more readily available.
SN  - 0002-8177
AD  - Chief of the Clinical Pharmacology Unit, Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, 10 Center Drive, Room 1N-103, Bethesda, MD 20892-1258
U2  - PMID: 9495047.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107285735
T1  - Commentary. Dietetics professionals and women's health research at the National Institutes of Health.
AU  - Kim SK
Y1  - 1998/02//
N1  - Accession Number: 107285735. Language: English. Entry Date: 19981001. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - National Institutes of Health (U.S.)
KW  - Women's Health
KW  - Research
KW  - Female
KW  - Research Priorities
KW  - Research Support
KW  - Minority Groups
KW  - Clinical Trials
KW  - Dietitians
KW  - Professional Role
SP  - 133
EP  - 136
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 98
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Nutrition Study Section, Center for Scientific Review, National Institutes of Health, Rockledge, II, Room 6158, MSC 7892, Bethesda, MD 20892-7892
U2  - PMID: 12515411.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Alexander, Duane
T1  - Prevention of mental retardation: Four decades of research <FNR></FNR><FN>This article is a US Government work and, as such, is in the public domain in the United States of America. </FN>.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1998/02//
VL  - 4
IS  - 1
M3  - Article
SP  - 50
EP  - 58
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - In the absence of curative therapy, and with treatment difficult and only partially successful, prevention plays a particularly important role in mental retardation. Research conducted during the past 40 years has identified new causes of mental retardation, new means of early diagnosis, and new ways of prevention. Prenatal diagnosis, newborn screening, dietary supplementation or restriction, hormone replacement, vaccination, and immunotherapy are just some of the techniques that have been applied to prevent mental retardation. Together, these interventions have slightly reduced the overall prevalence of mental retardation, and in some instances have nearly eliminated specific causes. Much remains to be done, including developing better means of early intervention for sociocultural mental retardation and convincing society of the value of investment in such approaches. In addition to these approaches, the research frontiers today are neurobiology, earlier prenatal diagnosis, fetal therapy, gene therapy, and reducing premature birth. The potential of these investigations makes the frontier of prevention research in mental retardation an exciting place to be. MRDD Research Reviews 1998;4:50–58. Published 1998 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL disabilities
KW  - PREVENTION
KW  - PRENATAL diagnosis
KW  - MEDICAL screening
KW  - GENE therapy
KW  - SOCIAL medicine
KW  - PATHOLOGICAL psychology
KW  - mental retardation
KW  - nutrition
KW  - preening environment
KW  - prematurity
KW  - prevention
KW  - vaccines
N1  - Accession Number: 11781939; Alexander, Duane 1; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1998, Vol. 4 Issue 1, p50; Subject Term: MENTAL disabilities; Subject Term: PREVENTION; Subject Term: PRENATAL diagnosis; Subject Term: MEDICAL screening; Subject Term: GENE therapy; Subject Term: SOCIAL medicine; Subject Term: PATHOLOGICAL psychology; Author-Supplied Keyword: mental retardation; Author-Supplied Keyword: nutrition; Author-Supplied Keyword: preening environment; Author-Supplied Keyword: prematurity; Author-Supplied Keyword: prevention; Author-Supplied Keyword: vaccines; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jacobson, Jill D.
AU  - Crofford, Leslie J.
AU  - Sun, Lihua
AU  - Wilder, Ronald L.
T1  - Cyclical Expression of GnRH and GnRH Receptor mRNA in Lymphoid Organs.
JO  - Neuroendocrinology
JF  - Neuroendocrinology
Y1  - 1998/02//
VL  - 67
IS  - 2
M3  - Article
SP  - 117
EP  - 125
SN  - 00283835
AB  - Gonadotropin-releasing hormone (GnRH) is known to possess dirct immunomodulatory effects. We have previously demonstrated that the administration of GnRH analogues modulates the expression of murine lupus independently of effects on gonadal steroids. We speculate that GnRH exerts direct actions at the level of the immune cells. GnRH receptors have been identified on lymphocytes. Because GnRH and GnRH receptor (GnRH-R) expression varies with the estrous cycle at the levels of the hypothalamus and pituitary, we speculated that similar cyclicity might be demonstrable in lymphoid tissue. In this report, we used competitive reverse transcription PCR to quantitate the expression of GnRH and GnRH-R mRNA in lymphoid organs throughout the estrous cycle in mice. We demonstrate that the pattern of expression of GnRH-R mRNA in spleen agrees closely with the pattern in the pituitaries of the same mice and the pattern previously reported in the rat pituitary, with significantly increased levels of expression seen on the afternoon of proestrus compared to the morning of metestrus. A similar pattern is seen with GnRH-R mRNA expression in the thymus. Furthermore, we show that the expression of GnRH mRNA in both thymus and spleen agrees closely with the pattern of expression of its receptor, with significantly increased levels of expression seen on the afternoon of proestrus compared to the morning of metestrus. Additional in vitro studies demonstrate that both GnRH and estradiol significantly increase the expression of GnRH-R mRNA in immune cells. These findings support an active role for GnRH in the immune system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Neuroendocrinology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE expression
KW  - LUTEINIZING hormone releasing hormone
KW  - MESSENGER RNA
KW  - LYMPHOID tissue
KW  - THYMUS
KW  - Gonadal steroids
KW  - Gonadotropin-releasing hormone
KW  - Gonadotropin-releasing hormone receptor
KW  - Molecular neuroendocrinology
KW  - Neuroimmune interactions
KW  - Thymus
N1  - Accession Number: 11373679; Jacobson, Jill D. 1; Email Address: jjacobson@CMH.edu Crofford, Leslie J. 2 Sun, Lihua 1 Wilder, Ronald L. 3; Affiliation:  1: Section of Endocrinology, Children's Mercy Hospital, Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Mo., USA  2: Division of Rheumatology, University of Michigan School of Medicine, Ann Arbor, Mich., USA  3: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 67 Issue 2, p117; Subject Term: GENE expression; Subject Term: LUTEINIZING hormone releasing hormone; Subject Term: MESSENGER RNA; Subject Term: LYMPHOID tissue; Subject Term: THYMUS; Author-Supplied Keyword: Gonadal steroids; Author-Supplied Keyword: Gonadotropin-releasing hormone; Author-Supplied Keyword: Gonadotropin-releasing hormone receptor; Author-Supplied Keyword: Molecular neuroendocrinology; Author-Supplied Keyword: Neuroimmune interactions; Author-Supplied Keyword: Thymus; Number of Pages: 9p; Illustrations: 8 Graphs; Document Type: Article
L3  - 10.1159/000054306
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Andersen, R. N.
AU  - Ganeshkumar, N.
AU  - Kolenbrander, P. E.
T1  - <em>Helicobacter pylori</em> adheres selectively to <em>Fusobacterium</em> spp.
JO  - Oral Microbiology & Immunology
JF  - Oral Microbiology & Immunology
Y1  - 1998/02//
VL  - 13
IS  - 1
M3  - Article
SP  - 51
EP  - 54
SN  - 09020055
AB  - <em>Helicobacter</em> pylon strains ATCC 43504 and ATCC 43629 were tested for their ability to coaggregate with 79 strains of bacteria representing 16 genera. All except two of the strains were of human origin, and most of the strains were isolated from the oral cavity. The helicobacters failed to coaggregate with all strains except the fusobacteria. Several coaggregations were partially or completely inhibited by lactose. Strong coaggregation was seen with each of four subspecies of <em>Fusobacterium nucleatum</em> and with <em>Fusobacterium periodonticum</em> ATCC 33693, all of human dental plaque origin. In contrast, the helicobacters failed to coaggregate with non-plaque isolates, <em>Fusobacterium mortiferum</em> ATCC 25557 and <em>Fusobacterium ulcerans</em> ATCC 49185. Heat treatment of the fusobacteria inactivated their ability to coaggregate, whereas heating of the helicobacter partners had no effect, suggesting the presence of an adhesin on the fusobacteria and a corresponding receptor on the helicobacters. The potential ability of <em>II. pylori</em> to colonize the oral cavity by adhering selectively to the ubiquitous fusobacteria gives credence to the possibility that dental plaque may serve as a reservoir for this pathogen outside of the stomach. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oral Microbiology & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Sequestration (Chemistry)
KW  - Bacteria
KW  - Prokaryotes
KW  - Helicobacter pylori
KW  - Fusobacterium
KW  - Dental plaque
KW  - helicobacter oral sequestration.
KW  - Helicobacter-Fusobacterium coaggregation
N1  - Accession Number: 12600193; Andersen, R. N. 1; Ganeshkumar, N. 2; Kolenbrander, P. E. 1; Affiliations: 1: Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.; 2: Forsyth Dental Center, Boston, Massachusetts, USA.; Issue Info: Feb1998, Vol. 13 Issue 1, p51; Thesaurus Term: Sequestration (Chemistry); Thesaurus Term: Bacteria; Thesaurus Term: Prokaryotes; Subject Term: Helicobacter pylori; Subject Term: Fusobacterium; Subject Term: Dental plaque; Author-Supplied Keyword: helicobacter oral sequestration.; Author-Supplied Keyword: Helicobacter-Fusobacterium coaggregation; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Chhabra, R. S.
AU  - Herbert, R. A.
AU  - Roycroft, J. H.
AU  - Chou, B.
AU  - Miller, R. A.
AU  - Renne, R. A.
T1  - Carcinogenesis Studies of Tetrahydrofuran Vapors in Rats and Mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/02//
VL  - 41
IS  - 2
M3  - Article
SP  - 183
EP  - 188
SN  - 10966080
AB  - Tetrahydrofuran (THF) is a widely used industrial solvent and was selected for carcinogenesis studies by the National Toxicology Program (NTP) because of its potential for widespread occupational exposure in humans and a lack of information on animal toricity and carcinogenicity. Groups of 50 male and 50 female F344/N rats and B6C3F, mice were exposed to 0,200,600, or 1800 ppm THF by inhalation, 6 h per day, 5 days per week, for 105 weeks. Survival and mean body weights of male and female rats exposed to THF were comparable to that of the controls. No clinical findings or nonneoplastic lesions related to THF exposure were observed in male or female rats. The incidences of renal tubule epithelial adenoma or carcinoma (combined) in exposed male rats occurred with a positive trend, and in males exposed to 600 and 1800 ppm exceeded the historical range for controls in 2-year NTP inhalation studies. There were no other neoplastic lesions related to THF exposure observed in male or female rats. After week 36, the survival of male mice exposed to 1800 ppm was significantly lower than that of the controls. Mean body weights of male and female mice exposed to THF were similar to those of the controls throughout the study. Male mice exposed to 1800 ppm were observed in a state of narcosis during and up to 1 h after the exposure periods. Nonneoplastic lesions related to THF exposure were not observed in male or female mice. The neoplastic lesions related to THF exposure were seen in female mice only. In female mice exposed to 1800 ppm, the incidences of hepatocellular neoplasms were significantly greater than those in the controls. In conclusion, there was some evidence of carcinogenic activity of THF in male F344/N rats due to increased incidences of adenoma or carcinoma (combined) of the kidney at the 600 and 1800 ppm exposure levels. There was clear evidence of carcinogenic activity in female B6C31, mice based on increased incidences of hepatocellular neoplasms at the 1800 ppm exposure level. THF was not carcinogenic in female rats or male mice exposed at 200, 600, or 1800 ppm. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83181928; Chhabra, R. S. 1,2; Herbert, R. A. 1,2; Roycroft, J. H. 1,2; Chou, B. 2; Miller, R. A. 2; Renne, R. A. 2; Affiliations: 1: National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; 2: Battelle Pacific Northwest Laboratories P.O. Box 999, Richland, Washington 99352; Issue Info: 1998, Vol. 41 Issue 2, p183; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-00321-002
AN  - 2006-00321-002
AU  - Wharton, Charles M.
AU  - Grafman, Jordan
T1  - Deductive reasoning and the brain.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1998/02//
VL  - 2
IS  - 2
SP  - 54
EP  - 59
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Grafman, Jordan, Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US, 20892-1440
N1  - Accession Number: 2006-00321-002. PMID: 21227066 Partial author list: First Author & Affiliation: Wharton, Charles M.; Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20070723. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Frontal Lobe; Inductive Deductive Reasoning; Neurosciences. Classification: Cognitive Processes (2340); Neuropsychology & Neurology (2520). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 6. Issue Publication Date: Feb, 1998. 
AB  - Although relatively few in number, cognitive neuroscience studies of reasoning have two general implications for cognitive theories of deduction. First, an important distinction among these theories is whether they focus on the effect of personally relevant content on the processes and representations underlying deductive reasoning. Evidence is reviewed indicating that there is a neuroanatomical basis for both content-independent and content-dependent theories of deduction. Clinical and neuroimaging studies appear to show that content-independent reasoning is mediated by the left hemisphere, whereas content-dependent reasoning is mediated by regions in the right hemisphere and the bilateral ventromedial frontal cortex. In normal subjects, reasoning is likely to be based on contributions from both hemispheres. Second, clinical evidence indicates that the visuospatial processes used in deductive reasoning are mediated by the posterior areas of the left hemisphere, and that verbal and visuospatial reasoning representations overlap at the neuroanatomical level. This finding weighs against the claims of mental-model theory that deduction involves a significant nonverbal component. Further investigation, particularly with contemporary neuroimaging methods, is needed to test these preliminary conclusions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - deductive reasoning
KW  - brain
KW  - cognitive neuroscience
KW  - bilateral ventromedial frontal cortex
KW  - 1998
KW  - Cognitive Processes
KW  - Frontal Lobe
KW  - Inductive Deductive Reasoning
KW  - Neurosciences
KW  - 1998
DO  - 10.1016/S1364-6613(98)01122-X
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UR  - jgr@box-j.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40342-017
AN  - 2015-40342-017
AU  - Davenport, Roger W.
AU  - Thies, Edda
AU  - Zhou, Renping
AU  - Nelson, Phillip G.
T1  - Cellular localization of ephrin-A2, ephrin-A5, and other functional guidance cues underlies retinotopic development across species.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/02//
VL  - 18
IS  - 3
SP  - 975
EP  - 986
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Davenport, Roger W., Laboratory of Developmental Neurobiology, National Institutes of Health, 49 Convent Drive, MSC4480, Building 49, Room 5A38, Bethesda, MD, US, 20892-4480
N1  - Accession Number: 2015-40342-017. PMID: 9437019 Partial author list: First Author & Affiliation: Davenport, Roger W.; Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160310. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain Development; Cues; Discrimination Learning; Superior Colliculus. Minor Descriptor: Rodents. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Feb, 1998. Publication History: Accepted Date: Nov 6, 1997; Revised Date: Nov 4, 1997; First Submitted Date: Sep 5, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Avian retinotectal and rodent retinocollicular systems are general model systems used to examine developmental processes that underpin topographically organized neuronal circuits. The two systems rely on guidance components to establish their precise retinotopic maps, but many cellular events differ during their development. For example, compared with the chick, a generally less restricted outgrowth pattern is observed when retinae innervate their targets in rodents. Cellular or molecular distributions of guidance components may account for such differences in retinotopic development across species. Candidate repellent molecules, such as ephrin-A2 and ephrin-A5, have been cloned in both chick and rodents; however, it has not yet been shown in rodents that living cells express sufficient amounts of any repellent components to deter outgrowth. We used a coculture assay that gives cellular resolution of retinotarget interactions and demonstrate that living, caudal superior colliculus cells selectively prevent extension of axons from temporal regions of the retinae. Time-lapse video microscopy revealed the cellular localization of permissive and repulsive guidance components in rodents, which differed from that in chick. To analyze the potential molecular basis for these differences, we investigated the function and localization of ephrin-A2 and -A5. Cells transfected with ephrin-A2 and -A5 selectively repelled retinal axons. Ephrin-A2 and -A5 RNA expression patterns differed across cell populations and between species, suggesting molecular mechanisms and key cellular interactions that may underlie fundamental differences in the development of retinotectal and retinocollicular maps. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - retinocollicular
KW  - topographic projection
KW  - growth cone
KW  - neuronal development
KW  - filopodia
KW  - repulsion
KW  - retraction
KW  - retinotopic
KW  - retinotectal
KW  - Eph receptor tyrosine kinase
KW  - ephrin
KW  - guidance cues
KW  - 1998
KW  - Brain Development
KW  - Cues
KW  - Discrimination Learning
KW  - Superior Colliculus
KW  - Rodents
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40342-029
AN  - 2015-40342-029
AU  - Ziemann, Ulf
AU  - Corwell, Brian
AU  - Cohen, Leonardo G.
T1  - Modulation of plasticity in human motor cortex after forearm ischemic nerve block.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/02//
VL  - 18
IS  - 3
SP  - 1115
EP  - 1123
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ziemann, Ulf, National Institutes of Health, Building 10, Room 5N234, 10 Center Drive, MSC-1430, Bethesda, MD, US, 20892-1428
N1  - Accession Number: 2015-40342-029. PMID: 9437031 Partial author list: First Author & Affiliation: Ziemann, Ulf; Human Cortical Physiology Unit, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160310. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ziemann, Ulf. Major Descriptor: Motor Cortex; Transcranial Magnetic Stimulation; Synaptic Plasticity. Minor Descriptor: Cerebral Ischemia; Motor Processes. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 1998. Publication History: Accepted Date: Nov 7, 1997; Revised Date: Nov 3, 1997; First Submitted Date: Aug 8, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Deafferentation leads to cortical reorganization that may be functionally beneficial or maladaptive. Therefore, we were interested in learning whether it is possible to purposely modulate deafferentation-induced reorganization. Transient forearm deafferentation was induced by ischemic nerve block (INB) in healthy volunteers. The following five interventions were tested: INB alone; INB plus low-frequency (0.1 Hz) repetitive transcranial magnetic stimulation of the motor cortex ipsilateral to INB (INB + rTMSi); rTMSi alone; INB plus rTMS of the motor cortex contralateral to INB (INB + rTMSc); and rTMSc alone. Plastic changes in the motor cortex contralateral to deafferentation were probed with TMS, measuring motor threshold (MT), motor evoked-potential (MEP) size, and intracortical inhibition (ICI) and facilitation (ICF) to the biceps brachii muscle proximal to the level of deafferentation. INB alone induced a moderate increase in MEP size, which was significantly enhanced by INB1rTMSc but blocked by INB + rTMSi. INB alone had no effect on ICI or ICF, whereas INB + rTMSc reduced ICI and increased ICF, and conversely, INB + rTMSi deepened ICI and suppressed ICF. rTMSi and rTMSc alone were ineffective in changing any of these parameters. These findings indicate that the deafferented motor cortex becomes modifiable by inputs that are normally subthreshold for inducing changes in excitability. The deafferentation-induced plastic changes can be up-regulated by direct stimulation of the 'plastic' cortex and likely via inhibitory projections down-regulated by stimulation of the opposite cortex. This modulation of cortical plasticity by noninvasive means might be used to facilitate plasticity when it is primarily beneficial or to suppress it when it is predominately maladaptive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - motor cortical excitability
KW  - cortical reorganization
KW  - transient forearm deafferentation
KW  - ischemic nerve block
KW  - human
KW  - transcranial magnetic stimulation
KW  - modulation of plasticity
KW  - 1998
KW  - Motor Cortex
KW  - Transcranial Magnetic Stimulation
KW  - Synaptic Plasticity
KW  - Cerebral Ischemia
KW  - Motor Processes
KW  - 1998
U1  - Sponsor: Deutsche Forschungsgemeinschaft, Germany. Grant: Zi 542/1–1. Recipients: Ziemann, Ulf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40342-029&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1998-00196-010
AN  - 1998-00196-010
AU  - Classen, Joseph
AU  - Liepert, Joachim
AU  - Wise, Steven P.
AU  - Hallett, Mark
AU  - Cohen, Leonardo G.
T1  - Rapid plasticity of human cortical movement representation induced by practice.
JF  - Journal of Neurophysiology
JO  - Journal of Neurophysiology
JA  - J Neurophysiol
Y1  - 1998/02//
VL  - 79
IS  - 2
SP  - 1117
EP  - 1123
CY  - US
PB  - American Physiological Society
SN  - 0022-3077
SN  - 1522-1598
N1  - Accession Number: 1998-00196-010. PMID: 9463469 Partial author list: First Author & Affiliation: Classen, Joseph; National Institutes of Health, National Inst of Neurological Disorders & Stroke, Human Cortical Physiology, Bethesda, MD, US. Release Date: 19980401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Motor Cortex; Motor Processes; Neural Plasticity; Practice. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. Page Count: 7. Issue Publication Date: Feb, 1998. 
AB  - Explored the hypothesis that performance of simple, unskilled repetitive thumb movements can trigger plasticity and that these plastic changes encode kinematic details of the practiced movement. 20 Ss (aged 20–64 yrs) participated. The study used focal transcranial magnetic stimulation (TMS) of the motor cortex to evoke isolated and directionally consistent thumb movements. Thumb movements then were practiced in a different direction. Subsequently, TMS came to evoke movements in or near the recently practiced direction for several minutes before returning to the original direction. To initiate a change of the TMS-evoked movement direction, the study required 15 or 30 min of continuous training in most of the Ss and, on 2 occasions, as little as 5 or 10 min. Substantially smaller effects followed more direct stimulation of corticofugal axons with transcranial electrical stimulation, pointing to the cortex as the site of plasticity. These findings suggest that the training rapidly, and transiently, established a change in the cortical network representing the thumb, which encoded kinematic details of the practiced movement. This phenomenon may be regarded as a short-term memory for movement and be the first step of skill acquisition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - performance of repetitive thumb movements
KW  - plasticity of human cortical movement representation
KW  - 20–64 yr olds
KW  - 1998
KW  - Motor Cortex
KW  - Motor Processes
KW  - Neural Plasticity
KW  - Practice
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1998-00196-010&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40342-033
AN  - 2015-40342-033
AU  - Wang, Ya-Xian
AU  - Wenthold, Robert J.
AU  - Ottersen, Ole P.
AU  - Petralia, Ronald S.
T1  - Endbulb synapses in the anteroventral cochlear nucleus express a specific subset of AMPA-type glutamate receptor subunits.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/02//
VL  - 18
IS  - 3
SP  - 1148
EP  - 1160
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Petralia, Ronald S., National Institute on Deafness and Other Communication Disorders, 36/ 5D08, 36 Convent Drive, MSC 4162, Bethesda, MD, US, 20892-4162
N1  - Accession Number: 2015-40342-033. PMID: 9437035 Partial author list: First Author & Affiliation: Wang, Ya-Xian; National Institute on Deafness and Other Communication Disorders, Bethesda, MD, US. Release Date: 20160310. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Auditory Stimulation; Glutamate Receptors; Neurotransmission; AMPA; Immunocytochemistry. Minor Descriptor: Acoustic Nerve; Amino Acids; Cochlea. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Feb, 1998. Publication History: Accepted Date: Nov 11, 1997; Revised Date: Nov 6, 1997; First Submitted Date: Sep 16, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - The anteroventral cochlear nucleus (AVCN) acts as the first relay center in the conduction of auditory information from the ear to the brain, and it probably performs a crucial role in sound localization. Auditory nerve input to the principal neurons of the AVCN, the spherical bushy cells, appears to be mediated by an excitatory amino acid such as glutamate, which acts at a specialized, large synaptic ending called an endbulb of Held. Presumably, endbulb synapses contain some specific combination of glutamate receptors to facilitate rapid neurotransmission of auditory signals. AMPA glutamate receptor composition at the endbulb synapses was examined with both light and electron microscope immunocytochemistry. Electron microscope localization of AMPA receptors was examined with two techniques, preembedding immunoperoxidase and postembedding immunogold, which provide maximum sensitivity and greatest accuracy, respectively. Dense and frequent labeling was seen with the AMPA receptor subunit antibodies GluR2/3 and GluR4, which were colocalized at the endbulb synapses. In contrast, immunolabeling with antibody to GluR2 was low. These data indicate that the major glutamate receptor at this synapse is an AMPA receptor made up mainly of GluR3 and GluR4 subunits. Receptors composed of these subunits display properties, such as calcium permeability and rapid desensitization, that facilitate their specialized functions in auditory information processing. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cochlear nucleus
KW  - auditory
KW  - AMPA
KW  - glutamate receptors
KW  - spherical bushy cell
KW  - endbulb
KW  - 1998
KW  - Auditory Stimulation
KW  - Glutamate Receptors
KW  - Neurotransmission
KW  - AMPA
KW  - Immunocytochemistry
KW  - Acoustic Nerve
KW  - Amino Acids
KW  - Cochlea
KW  - 1998
U1  - Sponsor: National Institute on Deafness and Other Communication Disorders, Intramural Research Program, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107254601
T1  - Diet during adolescence and risk of breast cancer among young women.
AU  - Potischman N
AU  - Weiss HA
AU  - Swanson CA
AU  - Coates RJ
AU  - Gammon MD
AU  - Malone KE
AU  - Brogan D
AU  - Stanford JL
AU  - Hoover RN
AU  - Brinton LA
Y1  - 1998/02/04/
N1  - Accession Number: 107254601. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: National Cancer Institute-Block Food-Frequency Questionnaire. NLM UID: 7503089. 
KW  - Breast Neoplasms -- Etiology
KW  - Diet -- Adverse Effects
KW  - Diet -- In Adolescence
KW  - Dairy Products
KW  - Dietary Fats
KW  - Fruit
KW  - Vegetables
KW  - Meat
KW  - Research Instruments
KW  - Case Control Studies
KW  - Logistic Regression
KW  - Questionnaires
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Chi Square Test
KW  - Adolescence
KW  - Female
KW  - Human
SP  - 226
EP  - 233
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 90
IS  - 3
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, Executive Plaza North, Rm. 430, Bethesda, MD 20892-7366
U2  - PMID: 9462680.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107254601&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107266190
T1  - Physician management of patients with heart failure and normal versus decreased left ventricular systolic function.
AU  - Fleg JL
AU  - Kitzman DW
AU  - Aronow WS
AU  - Rich MW
AU  - Gardin JM
AU  - Slone SA
Y1  - 1998/02/15/
N1  - Accession Number: 107266190. Corporate Author: Council on Geriatric Cardiology. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Brookdale Foundation, New York, New York. NLM UID: 0207277. 
KW  - Heart Failure -- Therapy
KW  - Professional Practice
KW  - Ventricular Dysfunction, Left -- Complications
KW  - Surveys
KW  - Questionnaires
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 506
EP  - 509
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
JA  - AM J CARDIOL
VL  - 81
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - Elsevier Inc.
SN  - 0002-9149
AD  - Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland
U2  - PMID: 9485147.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107266190&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kodjabachian, Laurent
AU  - Delaage, Michèle
AU  - Maurel, Corinne
AU  - Miassod, Raymond
AU  - Jacq, Bernard
AU  - Rosset, Roland
T1  - Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/02/15/
VL  - 17
IS  - 4
M3  - Article
SP  - 1063
EP  - 1075
SN  - 02614189
AB  - We report herein the isolation of ccf, a new gene located in region 82E and essential for Drosophila development. This gene, expressed throughout development, encodes a novel product of 68 kDa which is found in the nucleus during interphase and labels, in a novel pattern, centrosomes and chromosome arms during mitosis. Mutations in ccf give rise to late larvae with small imaginal discs and to adults showing appendages of reduced size, consistent with CCF involvement in cell proliferation. Neuroblast squash analyses show that CCF is required for proper condensation of mitotic chromosomes and, therefore, for progression through mitosis. Furthermore, we observe that adult ccf mutants as well as animals overexpressing CCF during larval stages exhibit homeotic transformations. We also find that mutations in the Pc-G genes Polycomb, polyhomeotic and Enhancer of zeste are enhanced by ccf mutations. Finally, we show that the CCF protein binds to specific sites on polytene chromosomes, many of which are shared with the Posterior sex combs Pc-G protein. Together, these results suggest a role for the CCF protein in the maintenance of chromosome structure during mitosis and interphase. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CENTROSOMES
KW  - GENE expression
KW  - CARRIER proteins
KW  - MITOSIS
KW  - CELL proliferation
KW  - MUTATION (Biology)
KW  - GENETICS
KW  - centrosome
KW  - chromosome condensation
KW  - drosophila
KW  - homeotic transformation
KW  - mitosis
N1  - Accession Number: 13006049; Kodjabachian, Laurent 1; Email Address: kodya@nih.gov Delaage, Michèle 2 Maurel, Corinne 3 Miassod, Raymond 2 Jacq, Bernard 2 Rosset, Roland 2; Affiliation:  1: National Institutes of Health, National Institute of Child Health and Human Development, Building 6B, Room 420, Bethesda, MD 20892, USA  2: Laboratoire de Génétique et Physiologie du Développement, Institut de Biologie du Développement de Marseille, CNRS Case 907, 13288 Marseille Cedex 9, France  3: Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, NY 10016, USA; Source Info: 2/15/98, Vol. 17 Issue 4, p1063; Subject Term: CENTROSOMES; Subject Term: GENE expression; Subject Term: CARRIER proteins; Subject Term: MITOSIS; Subject Term: CELL proliferation; Subject Term: MUTATION (Biology); Subject Term: GENETICS; Author-Supplied Keyword: centrosome; Author-Supplied Keyword: chromosome condensation; Author-Supplied Keyword: drosophila; Author-Supplied Keyword: homeotic transformation; Author-Supplied Keyword: mitosis; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/17.4.1063
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Naficy, Abdollah
AU  - Rao, Malla R.
AU  - Paquet, Christophe
AU  - Antona, Denise
AU  - Sorkin, Alan
AU  - Clemens, John D.
AU  - Naficy, A
AU  - Rao, M R
AU  - Paquet, C
AU  - Antona, D
AU  - Sorkin, A
AU  - Clemens, J D
T1  - Treatment and vaccination strategies to control cholera in sub-Saharan refugee settings: a cost-effectiveness analysis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1998/02/18/
VL  - 279
IS  - 7
M3  - journal article
SP  - 521
EP  - 525
SN  - 00987484
AB  - <bold>Context: </bold>There is significant controversy about how best to control cholera epidemics in refugee settings. Specifically, there is marked disagreement about whether to use oral cholera vaccines in these settings, despite the improved safety and effectiveness profiles of these vaccines.<bold>Objective: </bold>To determine the cost-effectiveness of alternative intervention strategies, including vaccination, to control cholera outbreaks in sub-Saharan refugee camps.<bold>Design: </bold>A cost-effectiveness analysis based on probabilities of cholera outcomes derived from epidemiologic data compiled for refugee settings in Malawi from 1987 through 1993; data for costs were obtained from a large relief agency that provides medical care in such settings.<bold>Setting and Participants: </bold>A hypothetical refugee camp with 50000 persons in sub-Saharan Africa evaluated for a 2-year period.<bold>Interventions: </bold>We compared the costs and outcomes of alternative strategies in which appropriate rehydration therapy for cholera is introduced preemptively (at the establishment of a camp) or reactively (once an epidemic is recognized) and in which mass immunization with oral B subunit killed whole-cell (BS-WC) cholera vaccine is added to a rehydration program either preemptively or reactively.<bold>Main Outcome Measures: </bold>Cost per cholera case prevented and cost per cholera death averted.<bold>Results: </bold>In a situation with no available rehydration therapy suitable for the management of severe cholera, a strategy of preemptive therapy ($320 per death averted) costs less and is more effective than a strategy of reactive therapy ($586 per death averted). Adding vaccination to preemptive therapy is expensive: $1745 per additional death averted for preemptive vaccination and $3833 per additional death averted for reactive vaccination. However, if the cost of vaccine falls below $0.22 per dose, strategies combining vaccination and preemptive therapy become more cost-effective than therapy alone.<bold>Conclusions: </bold>Provision for managing cholera outbreaks at the inception of a refugee camp (preemptive therapy) is the most cost-effective strategy for controlling cholera outbreaks in sub-Saharan refugee settings. Should the price of BS-WC cholera vaccine fall below $0.22 per dose, however, supplementation of preemptive therapy with mass vaccination will become a cost-effective option. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHOLERA
KW  - REFUGEE camps
KW  - EPIDEMICS
KW  - AFRICA, Sub-Saharan
N1  - Accession Number: 243208; Naficy, Abdollah Rao, Malla R. Paquet, Christophe Antona, Denise Sorkin, Alan Clemens, John D. Naficy, A 1 Rao, M R Paquet, C Antona, D Sorkin, A Clemens, J D; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, Md 20892, USA; Source Info: 2/18/98, Vol. 279 Issue 7, p521; Subject Term: CHOLERA; Subject Term: REFUGEE camps; Subject Term: EPIDEMICS; Subject Term: AFRICA, Sub-Saharan; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 5p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107271695
T1  - Preventing hypertension: a new urgency.
AU  - Cutler JA
AU  - Simons-Morton DG
AU  - Willett W
Y1  - 1998/02/28/
N1  - Accession Number: 107271695. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0246161. 
KW  - Hypertension -- Prevention and Control
KW  - Life Style
KW  - Patient Education
KW  - Primary Health Care
KW  - Weight Loss
KW  - Smoking
KW  - Cardiovascular Risk Factors
KW  - Exercise
KW  - Diet
SP  - 64
EP  - 74
JO  - Patient Care
JF  - Patient Care
JA  - PATIENT CARE
VL  - 32
IS  - 4
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Hypertension is preventable, and lifestyle changes may reduce a patient's medication requirements. Why this renewed emphasis on prevention? After decades of medical progress against it, hypertension threatens public health more than ever.
SN  - 0031-305X
AD  - Director, Clinical Applications and Prevention Program, National Heart, Lung, and Blood Institute, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107255643
T1  - Weaning from mechanical ventilatory support: refinement of a model.
AU  - Knebel A
AU  - Shekleton ME
AU  - Burns S
AU  - Clochesy JM
AU  - Hanneman SK
Y1  - 1998/03//1998 Mar
N1  - Accession Number: 107255643. Language: English. Entry Date: 19980501. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9211547. 
KW  - Ventilator Weaning
SP  - 149
EP  - 152
JO  - American Journal of Critical Care
JF  - American Journal of Critical Care
JA  - AM J CRIT CARE
VL  - 7
IS  - 2
CY  - Alisa Veijo, California
PB  - American Association of Critical-Care Nurses
AB  - The American Association of Critical-Care Nurses sponsored the third National Study Group to advance the science of weaning from mechanical ventilatory support and to guide clinical practice. The study group proposed a model of weaning in 1994 to provide an organizing framework for scientific inquiry. Since the model was first proposed, the ongoing work of the study group has led to refinement of the model. The purpose of this brief communication is to inform critical care clinicians and researchers about the refinements.
SN  - 1062-3264
AD  - National Institutes of Health, Clinical Center Nursing Department, Bethesda, Md
U2  - PMID: 9509229.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107255643&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Breslow, Rosalind A.
AU  - Ross, Sharon A.
AU  - Weed, Douglas L.
T1  - Quality of Reviews in Epidemiology.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/03//
VL  - 88
IS  - 3
M3  - Article
SP  - 475
EP  - 477
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined the quality of recent reviews in epidemiology. Methods. All 1995 issues of 7 widely read epidemiology journals were searched to identify reviews. Results. Twenty-nine reviews were identified. Methodology was not specified or incomplete for literature searches in 79% of reviews; the same was true for inclusion criteria in 83% and for combining studies in 62%. More than 60% of the reviews were not methodologically systematic. Conclusions. There is a need to improve the quality of review papers in epidemiology. If systematic methodology were followed more frequently, epidemiologic science and its application could be improved. (Am J Public Health. 1998;88:475-477) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPIDEMIOLOGY
N1  - Accession Number: 453234; Breslow, Rosalind A. 1 Ross, Sharon A. 1 Weed, Douglas L. 1; Affiliation:  1: Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, Md.; Source Info: Mar98, Vol. 88 Issue 3, p475; Subject Term: EPIDEMIOLOGY; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 2363
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107277739
T1  - Public health briefs. Quality of reviews in epidemiology.
AU  - Breslow RA
AU  - Ross SA
AU  - Weed DL
Y1  - 1998/03//
N1  - Accession Number: 107277739. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: Overview Quality Assessment Questionnaire. NLM UID: 1254074. 
KW  - Epidemiological Research
KW  - Literature Review
KW  - Research Instruments
KW  - Human
SP  - 475
EP  - 477
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 88
IS  - 3
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study examined the quality of recent reviews in epidemiology. METHODS: All 1995 issues of 7 widely read epidemiology journals were searched to identify reviews. RESULTS: Twenty-nine reviews were identified. Methodology was not specified or incomplete for literature searches in 79% of reviews; the same was true for inclusion criteria in 83% and for combining studies in 62%. More than 60% of the reviews were not methodologically systematic. CONCLUSIONS: There is a need to improve the quality of review papers in epidemiology. If systematic methodology were followed more frequently, epidemiologic science and its application could be improved.
SN  - 0090-0036
AD  - National Cancer Institute, 6130 Executive Blvd, EPN-313, Bethesda, MD 20892-7344
U2  - PMID: 9518988.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107277739&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hedges, Scott
AU  - El-Mallakh, Rif
AU  - Issa, Fuad
AU  - Elkashef, Ahmed
AU  - Bigelow, Llewellyn
AU  - Wyatt, Richard
T1  - Clonidine Does Not Potentiate the Antipsychotic Effects of Neuroleptics in Chronically Ill Patients.
JO  - Annals of Clinical Psychiatry (Springer Science & Business Media B.V.)
JF  - Annals of Clinical Psychiatry (Springer Science & Business Media B.V.)
Y1  - 1998/03//
VL  - 10
IS  - 1
M3  - Article
SP  - 3
EP  - 7
SN  - 10401237
AB  - Clonidine is a centrally acting antihypertensive and has been prescribed widely for more than 20 years. Because it decreases central norepinephrine activity, clonidine has been investigated as an antipsychotic. In most of the preliminary studies, clonidine was tested as the sole antipsychotic agent. We performed a double-blind, placebo-controlled, crossover study to compare a placebo plus a neuroleptic to clonidine plus a neuroleptic in a group of 16 chronically psychotic patients. Of these 16, 3 dropped out secondary to side effects of the clonidine and 1 withdrew from the study. The clonidine dosage varied from 0.2 to 0.6 mg per day. The concurrent neuroleptic (one of the following: haloperidol, thiothixene, thioridazine, mesoridazine, or fluphenazine) averaged 34 mg per day of haloperidol equivalents. Symptoms were monitored using the Psychiatric Symptoms Assessment Scale. The data provided evidence that a clonidine/neuroleptic combination was not more effective than a neuroleptic alone in this group of patients. These data suggest that the central antino-repinephrine activity of a neuroleptic is not potentiated further by clonidine. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Annals of Clinical Psychiatry (Springer Science & Business Media B.V.) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Antipsychotic
KW  - clonidine
KW  - norepinephrine activity
KW  - potentiation of antipsychotics
KW  - psychosis
KW  - schizophrenia
N1  - Accession Number: 50246918; Hedges, Scott 1 El-Mallakh, Rif Issa, Fuad 2 Elkashef, Ahmed Bigelow, Llewellyn 2 Wyatt, Richard 2; Affiliation:  1: Seven Counties Services, 101 West Muhammed Ali Boulevard Louisville 40202  2: National Institute for Mental Health, Neuropsychiatric Research Hospital, Washington; Source Info: Mar1998, Vol. 10 Issue 1, p3; Author-Supplied Keyword: Antipsychotic; Author-Supplied Keyword: clonidine; Author-Supplied Keyword: norepinephrine activity; Author-Supplied Keyword: potentiation of antipsychotics; Author-Supplied Keyword: psychosis; Author-Supplied Keyword: schizophrenia; Number of Pages: 5p; Document Type: Article
L3  - 10.1023/A:1026194411452
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=50246918&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Hafner, R.;
AU  - Bethel, J.;
AU  - Power, M.;
AU  - Landry, B.;
AU  - Drusano, G.;
AU  - \ET/;
T1  - Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers
CT  - Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers
JO  - Antimicrobial Agents and Chemotherapy (USA)
JF  - Antimicrobial Agents and Chemotherapy (USA)
Y1  - 1998/03/01/
VL  - 42
IS  - Mar
SP  - 631
EP  - 639
SN  - 00664804
AD  - Div. of AIDS, NIAID, 6003 Executive Blvd., Rm. 2B25, Rockville, MD 20852-7620, USA Internet: rh23v@nih.gov
N1  - Accession Number: 36-03378; Language: English; Trade Name: 25-O-Desacetylrifabutin; Generic Name: LM-565; Chemical Name: Rifabutin--72559-06-9 Clarithromycin--81103-11-9 14(R)-Hydroxyclarithromycin--116836-41-0 LM-565--100324-63-8; Therapeutic Class: (8:16); AHFS Class: Antituberculars rifabutin (8:12.12); AHFS Class: Macrolides clarithromycin; References: 43; Journal Coden: AMACCQ; Human Indicator: Yes; Section Heading: Drug Interactions; ToxicityDrug Metabolism and Body Distribution; Abstract Author: Ellen Katz Neumann
N2  - A randomized study of the toxicity and potential pharmacokinetic interactions of rifabutin and clarithromycin was conducted in 32 patients with human immunodeficiency virus (HIV) infections who received an oral tablet of 500 mg clarithromycin every 12 h or an oral capsule of 300 mg/day rifabutin alone for 14 days and both drugs for an additional 4 wk. Of the 29 patients who started combined therapy, 2 patients prematurely discontinued treatment due to toxicity, and 19 of 29 reported nausea, vomiting, and/or diarrhea. Rifabutin caused a mean decrease of 44% in the plasma AUC of clarithromycin and a mean increase of 57% in the AUC of its metabolite, 14(R)-hydroxyclarithromycin. Clarithromycin produced a mean increase of 99% in the AUC of rifabutin and a mean increase of 375% in the AUC of its metabolite, LM-565 (25-O-desacetylrifabutin).
KW  - Rifabutin--interactions-;
KW  - Clarithromycin--interactions-;
KW  - 14(R)-Hydroxyclarithromycin--metabolites-;
KW  - LM-565--metabolites-;
KW  - Antituberculars--rifabutin--interactions;
KW  - Macrolides--clarithromycin--interactions;
KW  - Drug interactions--clarithromycin and rifabutin--pharmacokinetics;
KW  - Drug interactions--rifabutin and clarithromycin--pharmacokinetics;
KW  - Pharmacokinetics--rifabutin--interactions;
KW  - Pharmacokinetics--clarithromycin--interactions;
KW  - Toxicity--rifabutin--interactions;
KW  - Toxicity--clarithromycin--interactions;
KW  - Metabolism--rifabutin--interactions;
KW  - Metabolism--clarithromycin--interactions;
KW  - Blood levels--rifabutin--interactions;
KW  - Blood levels--clarithromycin--interactions;
KW  - Blood levels--14(R)-hydroxyclarithromycin--metabolites;
KW  - Blood levels--LM-565--metabolites;
KW  - HIV infections--rifabutin--interactions;
KW  - HIV infections--clarithromycin--interactions;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=36-03378&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Wiener, Lori S.
AU  - Battles, Haven B.
AU  - Heilman, Nancy E.
T1  - Factors Associated with Parents' Decision to Disclose Their HIV Diagnosis to Their Children.
JO  - Child Welfare
JF  - Child Welfare
Y1  - 1998/03//Mar/Apr98
VL  - 77
IS  - 2
M3  - Article
SP  - 115
EP  - 135
PB  - Child Welfare League of America
SN  - 00094021
AB  - The article discusses the factors associated with HIV infected parents' decision to disclose their HIV diagnosis to their children. This is a stressful decision to make, not only because of the fatal nature of the disease, but because disclosing an HIV diagnosis often entails a conversation about parental acquisition of the virus. In addition, disclosing the parents' diagnosis may lead to a disclosure of the child's diagnosis, if the child is HIV-infected as well. A study, which sought to assess the variables associated with the process of this disclosure and its consequences, was undertaken. The study also examined the factors underlying public disclosure of a child's HIV diagnosis.
KW  - HIV-positive persons
KW  - HIV infections -- Diagnosis
KW  - DISCLOSURE
KW  - INTERPERSONAL relations
KW  - TERMINALLY ill parents
KW  - FAMILY relations
KW  - PARENTS
KW  - PATIENTS
KW  - VIRAL diseases in children
N1  - Accession Number: 24229179; Wiener, Lori S. 1 Battles, Haven B. 2 Heilman, Nancy E. 3; Affiliation:  1: Coordinator, Pediatric HIV Psychosocial Support Program, National Cancer Institute, Bethesda, MD.  2: Research Associate, HIV/AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD.  3: Child Psychologist, Good Samaritan Hospital, Puyallup, Washington.; Source Info: Mar/Apr98, Vol. 77 Issue 2, p115; Subject Term: HIV-positive persons; Subject Term: HIV infections -- Diagnosis; Subject Term: DISCLOSURE; Subject Term: INTERPERSONAL relations; Subject Term: TERMINALLY ill parents; Subject Term: FAMILY relations; Subject Term: PARENTS; Subject Term: PATIENTS; Subject Term: VIRAL diseases in children; Number of Pages: 21p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 6858
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107285343
T1  - Factors associated with parents' decision to disclose their HIV diagnosis to their children.
AU  - Wiener LS
AU  - Battles HB
AU  - Heilman NE
Y1  - 1998/03//Mar/Apr98
N1  - Accession Number: 107285343. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: Beck Depression Inventory (BDI); Self-Perception Profile for Children (SPPC) (Harter); Arizona Social Support Interview Schedule (Barrera and Ainley); Family Environment Scale (FES) (Moos and Moos); Harter Self-Perception Profile for Adolescents (SPPA). NLM UID: 0372735. 
KW  - Truth Disclosure
KW  - HIV Infections -- Psychosocial Factors
KW  - Parents
KW  - Descriptive Statistics
KW  - Beck Depression Inventory, Revised Edition
KW  - Research Instruments
KW  - Structured Interview
KW  - Data Analysis, Statistical
KW  - Purposive Sample
KW  - Retrospective Design
KW  - Parent-Child Relations
KW  - Whites
KW  - Blacks
KW  - Hispanics
KW  - Child
KW  - Male
KW  - Female
KW  - Human
SP  - 115
EP  - 135
JO  - Child Welfare
JF  - Child Welfare
JA  - CHILD WELFARE
VL  - 77
IS  - 2
CY  - Washington, District of Columbia
PB  - Child Welfare League of America
SN  - 0009-4021
AD  - Pediatric HIV Psychosocial Support Program, National Cancer Institute, Bethesda, Washington
U2  - PMID: 9513994.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107285343&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107293084
T1  - Treatment of diabetes mellitus to reduce its chronic cardiovascular complications.
AU  - Savage PJ
Y1  - 1998/03//1998 Mar
N1  - Accession Number: 107293084. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8608087. 
KW  - Diabetes Mellitus -- Complications
KW  - Cardiovascular Diseases -- Etiology
SP  - 131
EP  - 138
JO  - Current Opinion in Cardiology
JF  - Current Opinion in Cardiology
JA  - CURR OPIN CARDIOL
VL  - 13
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0268-4705
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Room 8104, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20817
U2  - PMID: 9593553.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107293084&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Ban, Changill
AU  - Wei Yang
T1  - Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/03//3/1/98
VL  - 17
IS  - 5
M3  - Article
SP  - 1526
EP  - 1534
SN  - 02614189
AB  - MutS, MutL and MutH are the three essential proteins for initiation of methyl-directed DNA mismatch repair to correct mistakes made during DNA replication in Escherichia coli. MutH cleaves a newly synthesized and unmethylated daughter strand 5′ to the sequence d(GATC) in a hemi-methylated duplex. Activation of MutH requires the recognition of a DNA mismatch by MutS and MutL. We have crystallized MutH in two space groups and solved the structures at 1.7 and 2.3 Å resolution, respectively. The active site of MutH is located at an interface between two subdomains that pivot relative to one another, as revealed by comparison of the crystal structures, and this presumably regulates the nuclease activity. The relative motion of the two subdomains in MutH correlates with the position of a protruding C-terminal helix. This helix appears to act as a molecular lever through which MutS and MutL may communicate the detection of a DNA mismatch and activate MutH.With sequence homology to Sau3AI and structural similarity to PvuII endonuclease, MutH is clearly related to these enzymes by divergent evolution, and this suggests that type II restriction endonucleases evolved from a common ancestor. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA repair
KW  - ESCHERICHIA coli
KW  - DNA restriction enzymes
KW  - PROTEINS
KW  - DNA replication
KW  - NUCLEASES
KW  - ENZYMES
KW  - activation
KW  - dna repair
KW  - evolution
KW  - muth structures
KW  - restriction enzymes
N1  - Accession Number: 13006059; Ban, Changill 1 Wei Yang 1; Email Address: Wei.Yang@nih.gov; Affiliation:  1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA; Source Info: 3/1/98, Vol. 17 Issue 5, p1526; Subject Term: DNA repair; Subject Term: ESCHERICHIA coli; Subject Term: DNA restriction enzymes; Subject Term: PROTEINS; Subject Term: DNA replication; Subject Term: NUCLEASES; Subject Term: ENZYMES; Author-Supplied Keyword: activation; Author-Supplied Keyword: dna repair; Author-Supplied Keyword: evolution; Author-Supplied Keyword: muth structures; Author-Supplied Keyword: restriction enzymes; Number of Pages: 9p; Document Type: Article
L3  - 10.1093/emboj/17.5.1526
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13006059&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Costa, Paul T.
AU  - McCrae, Robert R.
T1  - Six approaches to the explication of facet-level traits: examples from conscientiousness.
JO  - European Journal of Personality
JF  - European Journal of Personality
Y1  - 1998/03//Mar/Apr98
VL  - 12
IS  - 2
M3  - Article
SP  - 117
EP  - 134
PB  - John Wiley & Sons, Inc.
SN  - 08902070
AB  - Proponents of the Five-Factor Model (FFM) of personality have argued for somewhat different conceptualizations of the factors. Ultimately, the factors are best understood by a specification of the traits (or facets ) that define them, and these facets in turn must be clearly conceptualized. Using as examples the Conscientiousness facet scales of the Revised NEO Personality Inventory, we discuss six approaches to understanding facet-level traits: (i) rational analysis of item content; (ii) characterization of the low pole, the psychological opposite; (iii) interpretation of external correlates; (iv) examination of secondary and tertiary factor loadings; (v) translation into the specialized languages of applied psychology; and (vi) case studies. © 1998 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Personality is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONSCIENCE
KW  - PERSONALITY assessment
KW  - PERSONALITY
KW  - APPLIED psychology
KW  - PERSONALITY & culture
N1  - Accession Number: 11819745; Costa, Paul T. 1; Email Address: PAULC@MVX.GRC.NIA.NIH.GOV McCrae, Robert R. 1; Affiliation:  1: Personality, Stress and Coping Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, U.S.A.; Source Info: Mar/Apr98, Vol. 12 Issue 2, p117; Subject Term: CONSCIENCE; Subject Term: PERSONALITY assessment; Subject Term: PERSONALITY; Subject Term: APPLIED psychology; Subject Term: PERSONALITY & culture; Number of Pages: 18p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ajmani, Ranjeet S.
AU  - Rifkind, Joseph M.
T1  - Hemorheological Changes during Human Aging.
JO  - Gerontology
JF  - Gerontology
Y1  - 1998/03//
VL  - 44
IS  - 2
M3  - Article
SP  - 111
EP  - 120
SN  - 0304324X
AB  - Various researchers have reported an association of hemorheological, hematological and metabolic changes with human aging. In this article an attempt has been made to review the present understanding of hemorheological changes and their probable role in the development of certain disorders/diseases during aging. The rise in fibrinogen, blood viscosity, plasma viscosity, red cell rigidity, fibrin degradation products and early activation of the coagulation system are some of the most prominent findings. It is generally agreed that a rise in blood viscosity factors leads to a state of hypoperfusion which results in impaired microcirculation. The cumulative effect of these changes appears in the form of a disturbed blood flow profile in older subjects leading to the development or aggravation of various circulatory disorders. Many studies indicate that hemorheological parameters that change in a number of diseases prevalent during aging include hypertension, stroke, diabetes. In addition correlations found between hemorheological parameters in the aged and decrements in certain cognitive functions and behavioral patterns suggest that hemorheological changes contribute to nonclinical aging changes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Gerontology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AGING
KW  - BLOOD viscosity
KW  - FIBRINOGEN
KW  - BLOOD coagulation
KW  - BLOOD flow
KW  - ERYTHROCYTES -- Deformability
KW  - Blood flow
KW  - Blood viscosity
KW  - Coagulation
KW  - Erythrocyte deformability
KW  - Fibrinogen
N1  - Accession Number: 11373290; Ajmani, Ranjeet S. 1 Rifkind, Joseph M. 1; Email Address: rifkind@lcmbsgi.nia.nih.gov; Affiliation:  1: Laboratory of Cellular and Molecular Biology, National Institute on Aging Gerontology Research Center, National Institutes of Health, Baltimore, Md., USA; Source Info: 1998, Vol. 44 Issue 2, p111; Subject Term: AGING; Subject Term: BLOOD viscosity; Subject Term: FIBRINOGEN; Subject Term: BLOOD coagulation; Subject Term: BLOOD flow; Subject Term: ERYTHROCYTES -- Deformability; Author-Supplied Keyword: Blood flow; Author-Supplied Keyword: Blood viscosity; Author-Supplied Keyword: Coagulation; Author-Supplied Keyword: Erythrocyte deformability; Author-Supplied Keyword: Fibrinogen; Number of Pages: 10p; Illustrations: 1 Diagram; Document Type: Article
L3  - 10.1159/000021993
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11373290&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wehr, Thomas A.
T1  - Effect of Seasonal Changes in Daylength on Human Neuroendocrine Function.
JO  - Hormone Research
JF  - Hormone Research
Y1  - 1998/03//
VL  - 49
IS  - 3/4
M3  - Article
SP  - 118
EP  - 124
SN  - 03010163
AB  - The circadian pacemaker imposes stereotypic patterns of daily variation on the activity of human neuroendocrine systems. In a number of cases, these patterns exhibit waveforms that are characterized by distinct diurnal and nocturnal periods with relatively discrete transitions between them (corresponding to a biological day, a biological dusk, a biological night, and a biological dawn). In humans, for example, diurnal periods of absence of melatonin secretion, low prolactin secretion, and falling levels of cortisol alternate with nocturnal periods of active melatonin secretion, high prolactin secretion and rising levels of cortisol. In response to light, the circadian pacemaker synchronizes the timing of the biological day and night so that their timing and duration are appropriately matched with the timing and duration of the solar day and night. As the pacemaker carries out this function, it is able to adjust the duration of the biological day and night to match seasonal variation in the duration of the solar day and night. Thus, after humans have been chronically exposed to long nights (scotoperiods), the duration of nocturnal periods of active melatonin secretion, high prolactin secretion and rising levels of cortisol is longer than it is after they have been chronically exposed to short nights. Furthermore, the sleep-related peak of growth hormone secretion is half as high after exposure to long nights as it is after exposure to short nights. These responses to seasonal changes in duration of the natural scotoperiod are suppressed in most individuals – especially men – who live in modern urban environments in which they are exposed to artificial light after dark and artificial darkness during the daytime. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Hormone Research is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CIRCADIAN rhythms
KW  - PHOTOPERIODISM
KW  - SEASONS
KW  - MELATONIN
KW  - PROLACTIN
KW  - SOMATOTROPIN
KW  - HYDROCORTISONE
KW  - Circadian rhythm
KW  - Cortisol
KW  - Growth hormone
KW  - Light
KW  - Melatonin
KW  - Photoperiod
KW  - Prolactin
KW  - Season
N1  - Accession Number: 11342442; Wehr, Thomas A. 1; Affiliation:  1: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Md., USA; Source Info: 1998, Vol. 49 Issue 3/4, p118; Subject Term: CIRCADIAN rhythms; Subject Term: PHOTOPERIODISM; Subject Term: SEASONS; Subject Term: MELATONIN; Subject Term: PROLACTIN; Subject Term: SOMATOTROPIN; Subject Term: HYDROCORTISONE; Author-Supplied Keyword: Circadian rhythm; Author-Supplied Keyword: Cortisol; Author-Supplied Keyword: Growth hormone; Author-Supplied Keyword: Light; Author-Supplied Keyword: Melatonin; Author-Supplied Keyword: Photoperiod; Author-Supplied Keyword: Prolactin; Author-Supplied Keyword: Season; Number of Pages: 7p; Document Type: Article
L3  - 10.1159/000023157
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11342442&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107267468
T1  - Bacillus of Calmette and Guerin vaccination for tuberculosis prevention in healthcare workers: how good is good enough?
AU  - Henderson DK
Y1  - 1998/03//1998 Mar
N1  - Accession Number: 107267468. Language: English. Entry Date: 19980701. Revision Date: 20150818. Publication Type: Journal Article; editorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099. 
KW  - BCG Vaccine -- Therapeutic Use
KW  - Tuberculosis -- Prevention and Control
KW  - Mycobacterium Tuberculosis
KW  - Health Personnel
KW  - Occupational Exposure -- Prevention and Control
SP  - 159
EP  - 161
JO  - Infection Control & Hospital Epidemiology
JF  - Infection Control & Hospital Epidemiology
JA  - INFECT CONTROL HOSP EPIDEMIOL
VL  - 19
IS  - 3
PB  - Cambridge University Press
SN  - 0899-823X
AD  - Deputy Director for Clinical Care, Warren G. Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 9552182.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107267468&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Haj-Yahia, Muhammad M.
AU  - Dawud-Noursi, Samia
T1  - Predicting the Use of Different Conflict Tactics Among Arab Siblings in Israel: A Study Based On Social Learning Theory.
JO  - Journal of Family Violence
JF  - Journal of Family Violence
Y1  - 1998/03//
VL  - 13
IS  - 1
M3  - Article
SP  - 81
EP  - 103
PB  - Springer Science & Business Media B.V.
SN  - 08857482
AB  - The article presents a study conducted among 832 Arab adolescents from Israel, in an attempt to predict their use of different tactics (i.e., reasoning, verbal abuse, and physical violence) to resolve conflicts with siblings from the perspective of social learning theory. Different forms of the CT Scales were utilized to elicit information on Arab adolescents' exposure to and experience with different conflict tactics in their families of origin, as well as on their use of such tactics with siblings. Results indicate that the more they witnessed reasoning in their families of origin, the greater the likelihood that they would use the same tactic to resolve conflicts with their siblings. At the same time, the more they witnessed or experienced verbal abuse and physical violence, the greater their use of verbal and physical violence against their siblings. A detailed discussion of different patterns of violence in Arab families as reported by the adolescents is presented, and several implications of the study are addressed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Violence is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FAMILY violence
KW  - SOCIAL learning theory (Communication)
KW  - BROTHERS & sisters
KW  - SOCIAL learning
KW  - PSYCHOLOGY of learning
KW  - SOCIALIZATION
KW  - arab youth and violence
KW  - conflict tactics
KW  - experiencing domestic violence
KW  - sibling abuse and violence
KW  - Sibling Conflict
KW  - witnessing domestic violence
N1  - Accession Number: 18331360; Haj-Yahia, Muhammad M. 1 Dawud-Noursi, Samia 2; Affiliation:  1: The Paul Baerwald School of Social Work, The Hebrew University of Jerusalem, Israel  2: National Institute of Child Health and Human Development, The National Institute of Health, Bethesda, Maryland; Source Info: Mar98, Vol. 13 Issue 1, p81; Subject Term: FAMILY violence; Subject Term: SOCIAL learning theory (Communication); Subject Term: BROTHERS & sisters; Subject Term: SOCIAL learning; Subject Term: PSYCHOLOGY of learning; Subject Term: SOCIALIZATION; Author-Supplied Keyword: arab youth and violence; Author-Supplied Keyword: conflict tactics; Author-Supplied Keyword: experiencing domestic violence; Author-Supplied Keyword: sibling abuse and violence; Author-Supplied Keyword: Sibling Conflict; Author-Supplied Keyword: witnessing domestic violence; Number of Pages: 23p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107269641
T1  - Quality-of-life evaluation: when do terminal cancer patients and health-care providers agree?
AU  - Brunelli C
AU  - Costantini M
AU  - Di Giulio P
AU  - Gallucci M
AU  - Fusco F
AU  - Miccinesi G
AU  - Paci E
AU  - Peruselli C
AU  - Morino P
AU  - Piazza M
AU  - Tamburini M
AU  - Toscani F
Y1  - 1998/03//1998 Mar
N1  - Accession Number: 107269641. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Therapy Impact Questionnaire (TIQ). Grant Information: Health Authority of the Lombardy Region, project no. 584, Italian National Research Council, project: 'Clinical Application in Oncological Research' no. 96.00741.PF39. NLM UID: 8605836. 
KW  - Quality of Life
KW  - Cancer Patients
KW  - Terminally Ill Patients
KW  - Reproducibility of Results
KW  - Nurse-Patient Relations
KW  - Physician-Patient Relations
KW  - Clinical Trials
KW  - Spearman's Rank Correlation Coefficient
KW  - Summated Rating Scaling
KW  - Factor Analysis
KW  - Kruskal-Wallis Test
KW  - Research Instruments
KW  - Questionnaires
KW  - Funding Source
KW  - Human
SP  - 151
EP  - 158
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 15
IS  - 3
CY  - New York, New York
PB  - Elsevier Science
AB  - A multicenter study involving six palliative care units in Italy was carried out on 159 terminal cancer patients seen at home or in hospital. The physician or the nurse completed independently from the patient the Therapy Impact Questionnaire (TIQ), a questionnaire devised for quality-of-life evaluation in terminal cancer patients. The patient's assessment was used as the valid reference measurement to compare with the health-care workers' evaluation to assess the validity of the latter. The results showed that percentages of agreement were higher for physical than for psychological and cognitive symptoms, and that there was a greater agreement on the absence rather than on the presence of a problem. None of the characteristics of the patient nor of the proxy showed any statistically significant relationship with the two disagreement indexes. The results suggest that caution is needed in the use of health-care workers as alternative sources of information regarding patients' quality of life. (c) U.S. Cancer Pain Relief Committee, 1998 Published by Elsevier, New York, New York
SN  - 0885-3924
AD  - Physiological Research Division, National Cancer Institute, Milan
U2  - PMID: 9564116.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Cummings, Nancy Boucot
T1  - Ethical Issues and Dilemmas.
JO  - Journal of Women's Health
JF  - Journal of Women's Health
Y1  - 1998/03//
VL  - 7
IS  - 2
M3  - Article
SP  - 173
PB  - Mary Ann Liebert, Inc.
SN  - 10597115
AB  - The article identifies crucial ethical dilemmas and educate the "Journal of Women's Health" readers about how to resolve some of the resulting ethical issues. The media continually express strong opinions about issues that range from reproduction to the end of life. Health professionals and bioethicists are asked to provide opinions about these issues. It is essential that physicians and other health care professionals recognize these issues and develop a logical method for their analysis. Because the field of biomedical ethics is relatively new, many practicing physicians and investigators have not been trained in this discipline, and thus many health professional schools provide a course in biomedical ethics. This overview provides an introduction to the broad aspects of biomedical ethics that encompass almost every facet of modern medicine, from primary care to sophisticated clinical research. The economics of health care exert pressure on delivery of patient can that has provided new and troubling challenges for physicians.
KW  - PHYSICIANS
KW  - MEDICAL care -- Research
KW  - BIOETHICS
KW  - PROFESSIONAL ethics
KW  - PATIENTS
KW  - MEDICAL research
N1  - Accession Number: 5879938; Cummings, Nancy Boucot 1; Affiliation:  1: M.D., of the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.; Source Info: Mar98, Vol. 7 Issue 2, p173; Subject Term: PHYSICIANS; Subject Term: MEDICAL care -- Research; Subject Term: BIOETHICS; Subject Term: PROFESSIONAL ethics; Subject Term: PATIENTS; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107280097
T1  - Choices: biomedical ethics and women's health. Ethical issues and dilemmas.
AU  - Cummings NB
Y1  - 1998/03//
N1  - Accession Number: 107280097. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Ethics, Medical
SP  - 173
EP  - 176
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 7
IS  - 2
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1059-7115
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892
U2  - PMID: 9555679.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Boer de, Johan.G.
AU  - Provost, Scott.
AU  - Gorelick, Nancy.
AU  - Tindall, Ken
AU  - Glickman, Barry.W.
T1  - Spontaneous mutation in lacI transgenic mice: a comparison of tissues.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/03//
VL  - 13
IS  - 2
M3  - Article
SP  - 109
EP  - 114
PB  - Oxford University Press / USA
SN  - 02678357
AB  - The nature of spontaneous mutations in the lacl transgene of Big Blue® mice was determined in selected tissues. The mutant frequencies ranged from 2.5 × 10–5 to 7.1 × 10–5 for liver, spleen, bladder, stomach, kidney, bone marrow, lung and skin. We also determined the DNA sequence alterations in the mutants recovered from these tissues. In all tissues the predominant class of mutations was G:C→A:T transitions, most of which occurred at 5'–CpG–3' dinucleotide sequences. Bladder, kidney and skin display the highest contribution of G:C→A:T transitions. The second most common class of mutations was G:C→T:A transversions. All other base substitution classes contributed <10% each. Of the non–substitution events, the loss of a single base pair was the most frequently occurring event (<10%). The similarity of mutational spectra (in terms of kinds of mutations detected by the lacl transgenic system) in all tissues examined supports the idea that similar mutational pathways function in these tissues in the absence of chemical or physical stimulus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutation (Biology)
KW  - Comparative studies
KW  - Lac operon
KW  - Tissues -- Analysis
KW  - Transgenes
KW  - Mice as laboratory animals
KW  - Dinucleotides
KW  - Stimulus & response (Biology)
N1  - Accession Number: 79237950; Boer de, Johan.G. 1; Provost, Scott. 2; Gorelick, Nancy. 3; Tindall, Ken 4; Glickman, Barry.W. 1; Affiliations: 1: Centre for Environmental Health University of Victoria, Victoria, BC,Canada V8W 2Y2; 2: In Vitrogen Inc. Carlsbad, CA, USA; 3: Procter and Gamble Company Cincinnati, OH, USA; 4: National Institute of Environmental Health Sciences Research Triangle Park, NC, USA; Issue Info: Mar1998, Vol. 13 Issue 2, p109; Thesaurus Term: Mutation (Biology); Thesaurus Term: Comparative studies; Subject Term: Lac operon; Subject Term: Tissues -- Analysis; Subject Term: Transgenes; Subject Term: Mice as laboratory animals; Subject Term: Dinucleotides; Subject Term: Stimulus & response (Biology); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Donadel, Giulia
AU  - Marinos, Nancy
AU  - DeSilva, Mark G.
AU  - Jia Lu
AU  - Notkins, Abner L.
AU  - Lan, Michael S.
T1  - Molecular Cloning and Characterization of a Highly Basic Protein, IA-4, Expressed in Pancreatic Islets and Brain.
JO  - Neuroendocrinology
JF  - Neuroendocrinology
Y1  - 1998/03//
VL  - 67
IS  - 3
M3  - Article
SP  - 190
EP  - 196
SN  - 00283835
AB  - A substraction library was constructed from mouse insulinoma (βTC-1) and glucagonoma (αTC-1) cell lines. Differential screening and sequencing revealed a novel cDNA clone, IA-4, which was expressed in the islets of Langerhans and the brain. IA-4 cDNA is 1,007 bp in length and predicts a protein of 187 amino acids with a molecular mass of 19,940 D. Examination of the amino acid sequence showed a high content of arginine (18.7%), proline (14.4%), alanine (16.0%), leucine (13.4%) and glycine (9.6%). The deduced pI value is 12.5 indicating a highly basic protein. Northern blot analysis revealed a 1-kb mRNA highly expressed in brain, trigeminal ganglia and cell lines of neuroendocrine origin. Rabbit polyclonal antiserum raised against a synthetic IA-4 peptide, designated Pep-1, not only reacted with IA-4 recombinant protein, but also immunostained the islets of Langerhans and large neurons of the hippocampus, cerebral cortex, spinal cord, dorsal ganglia and Purkinje cells of the cerebellum. The high expression of IA-4 protein in neuroendocrine cells and its unique amino acid sequence suggest that IA-4 may have an important, but still undetermined, function in these special cell types. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Neuroendocrinology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ISLANDS of Langerhans -- Tumors
KW  - NEUROENDOCRINOLOGY
KW  - HIPPOCAMPUS (Brain)
KW  - CELL lines
KW  - GLUCAGONOMA
KW  - MICE
KW  - Cerebellum
KW  - Cortex
KW  - Hippocampus
KW  - Langerhans islets
KW  - Molecular neuroendocrinology
N1  - Accession Number: 11373686; Donadel, Giulia 1 Marinos, Nancy 1 DeSilva, Mark G. 1 Jia Lu 1 Notkins, Abner L. 1 Lan, Michael S. 1; Email Address: lan@yoda.nidr.nih-gov; Affiliation:  1: Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 67 Issue 3, p190; Subject Term: ISLANDS of Langerhans -- Tumors; Subject Term: NEUROENDOCRINOLOGY; Subject Term: HIPPOCAMPUS (Brain); Subject Term: CELL lines; Subject Term: GLUCAGONOMA; Subject Term: MICE; Author-Supplied Keyword: Cerebellum; Author-Supplied Keyword: Cortex; Author-Supplied Keyword: Hippocampus; Author-Supplied Keyword: Langerhans islets; Author-Supplied Keyword: Molecular neuroendocrinology; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 1 Color Photograph, 3 Diagrams; Document Type: Article
L3  - 10.1159/000054314
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107298362
T1  - The cloning and characterization of a novel cytochrome P450 family, CYP26, with specificity toward retinoic acid.
AU  - Haque M
AU  - Andreola F
AU  - DeLuca LM
Y1  - 1998/03//
N1  - Accession Number: 107298362. Language: English. Entry Date: 19981201. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405. 
KW  - Enzymes -- Metabolism
KW  - Retinoids -- Metabolism
SP  - 84
EP  - 85
JO  - Nutrition Reviews
JF  - Nutrition Reviews
JA  - NUTR REV
VL  - 56
IS  - 3
PB  - Oxford University Press / USA
SN  - 0029-6643
AD  - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255
U2  - PMID: 9564181.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104797379
T1  - Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests.
AU  - Elmer, G I
AU  - Pieper, J O
AU  - Negus, S S
AU  - Woods, J H
Y1  - 1998/03//1998 Mar
N1  - Accession Number: 104797379. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Analgesics, Opioid -- Pharmacodynamics
KW  - Genetics -- Physiology
KW  - Mice -- Physiology
KW  - Morphine -- Pharmacodynamics
KW  - Nociceptors -- Physiology
KW  - Acetic Acid -- Pharmacodynamics
KW  - Animal Studies
KW  - Chemical and Pharmacologic Phenomena
KW  - Female
KW  - Heat
KW  - Male
KW  - Nociceptors -- Drug Effects
KW  - Osmolar Concentration
KW  - Pain Threshold -- Physiology
SP  - 129
EP  - 140
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 75
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Behavioral Pharmacology and Genetics Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. gelme001@umabnet.ab.umd.edu
U2  - PMID: 9539682.
DO  - 10.1016/S0304-3959(97)00215-7
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107265555
T1  - Viewpoint on senior activity. Active seniors: protect them, don't neglect them.
AU  - Segal DD
AU  - Crespo CJ
AU  - Smit E
Y1  - 1998/03//Mar/Apr98
N1  - Accession Number: 107265555. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - Athletic Injuries -- In Old Age
KW  - Aging
KW  - Exercise -- In Old Age
KW  - Surveys
KW  - Athletes -- In Old Age
KW  - Questionnaires
KW  - Self Report
KW  - Descriptive Statistics
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 137
EP  - 139
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 113
IS  - 2
PB  - Sage Publications Inc.
SN  - 0033-3549
AD  - National Institute on Drug Abuse, Rm. 11A55, 5600 Fishers Lane, Rockville MD 20857. E-mail: ds119@nih.gov
U2  - PMID: 9719814.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bucher, John R.
AU  - Haseman, Joseph K.
AU  - Herbert, Ron A.
AU  - Hejtmancik, Milton
AU  - Ryan, Michael J.
T1  - Toxicity and Carcinogenicity Studies of Oxazepam in the Fischer 344 Rat.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/03//
VL  - 42
IS  - 1
M3  - Article
SP  - 1
EP  - 12
SN  - 10966080
AB  - Oxazepam and related benzodiazepines are used in the treatment of anxiety. Carcinogenicity studies of oxazepam were performed with the F344 rat because of marked differences in tumor responses observed in NTP studies with B6C3F1 and Swiss-Webster mice compared to the results of Sprague-Dawley rat studies submitted to the FDA by a manufacturer to support registration of the drug. Groups of 50 male and 50 female F344/N rats were fed diets containing 0, 625, 2500, or 5000 ppm oxazepam for up to 105 weeks. A stop-exposure group of 50 males and 50 females received 10,000 ppm oxazepam in diet for 26 weeks, after which animals received control diet. All 5000- and 10,000-ppm stop-exposure males died before the end of the study. Survival of 2500-ppm males and females was lower than that of controls. Body weight gains of 2500- and 5000-ppm males and females were less than those of controls. Male rats exposed to 2500 ppm had an increased incidence of renal tubule adenoma and hyperplasia. In addition, the incidences of renal tubule adenoma and hyperplasia were increased in the 10,000-ppm stop-exposure group. The incidences of nephropathy in exposed females were greater than those in controls, and the severity of nephropathy increased in exposed males. Epithelial hyperplasia and chronic inflammation of the nonglandular stomach were increased in males given 2500 and 5000 ppm and the incidence of ulcers of the nonglandular stomach in 2500-ppm males was also greater than that in controls. In males exposed to 5000 ppm, mineralization of the glandular stomach and erosion of the duodenum were observed. In females exposed to 2500 ppm, the incidences of epithelial hyperplasia, chronic inflammation, and ulcers of the nonglandular stomach and the incidence of erosion in the glandular stomach were increased. The incidences of centri-lobular hepatocyte hypertrophy in males and females given 2500 and 5000 ppm were greater than those in controls. In summary, there was equivocal evidence of carcinogenicity in males based on increased renal tubule adenomas in groups which also had significantly enhanced nephropathy. There was no evidence of carcinogenicity of oxazepam in females given a diet containing 625, 2500, or 5000 ppm for 2 years or 10,000 ppm for 6 months. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83180800; Bucher, John R. 1,2; Haseman, Joseph K. 1,2; Herbert, Ron A. 1,2; Hejtmancik, Milton 2; Ryan, Michael J. 2; Affiliations: 1: National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; 2: Battelle Memorial Laboratories Columbus, Ohio 43201; Issue Info: 1998, Vol. 42 Issue 1, p1; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107273763
T1  - Donor pool size and the risk of blood-borne Creutzfeldt-Jakob disease.
AU  - Brown P
Y1  - 1998/03//
N1  - Accession Number: 107273763. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - Blood Donors
KW  - Microbial Contamination
KW  - Plasma
KW  - Blood Transfusion -- Adverse Effects
KW  - Creutzfeldt-Jakob Syndrome -- Transmission
KW  - Risk Assessment
SP  - 312
EP  - 315
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 38
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5B21, MSC 4158, Bethesda, MD 20892-4158
U2  - PMID: 9563414.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2011-11021-006
AN  - 2011-11021-006
AU  - Bonds, Curley
AU  - Frye, Mark A.
AU  - Coudreaut, Michael F.
AU  - Cunningham, Malcom
AU  - Spearing, Melissa
AU  - McGuire, Michael
AU  - Guze, Barry
T1  - Cost reduction with maintenance ECT in refractory bipolar disorder.
JF  - The Journal of ECT
JO  - The Journal of ECT
JA  - J ECT
Y1  - 1998/03//
VL  - 14
IS  - 1
SP  - 36
EP  - 41
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 1095-0680
SN  - 1533-4112
AD  - Bonds, Curley, UCLA, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA, US, 90024
N1  - Accession Number: 2011-11021-006. PMID: 9661092 Other Journal Title: Convulsive Therapy. Partial author list: First Author & Affiliation: Bonds, Curley; UCLA Neuropsychiatric Institute, UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, US. Release Date: 20110919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Electroconvulsive Shock Therapy; Health Care Costs; Hospitalization; Outpatient Treatment. Minor Descriptor: Maintenance Therapy; Treatment Resistant Disorders. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340). Methodology: Clinical Case Study. References Available: Y. Page Count: 6. Issue Publication Date: Mar, 1998. Publication History: Accepted Date: Jul 30, 1997; First Submitted Date: Aug 5, 1996. Copyright Statement: Lippincott-Raven Publishers. 1998. 
AB  - A case report of outpatient maintenance electroconvulsive therapy (ECT) is presented in a patient with bipolar disorder type I refractory to conventional medication treatment but responsive to ECT. A cost comparison is made showing substantial savings when outpatient maintenance ECT is used in lieu of inpatient hospitalization with ECT. A detailed life chart illustrating multiple medication trials that failed to stabilize the patient accompanies the financial summary. This case highlights the advantages of outpatient maintenance ECT for bipolar depression particularly with regard to safety, efficacy, and significant health care cost reduction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cost reduction
KW  - treatment refractory bipolar disorder
KW  - maintenance electroconvulsive therapy
KW  - outpatient treatment vs inpatient hospitalization
KW  - maintenance therapy
KW  - 1998
KW  - Bipolar Disorder
KW  - Electroconvulsive Shock Therapy
KW  - Health Care Costs
KW  - Hospitalization
KW  - Outpatient Treatment
KW  - Maintenance Therapy
KW  - Treatment Resistant Disorders
KW  - 1998
DO  - 10.1097/00124509-199803000-00006
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13475-001
AN  - 2008-13475-001
AU  - Miles, F. A.
T1  - The neural processing of 3-D visual information: Evidence from eye movements.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/03//
VL  - 10
IS  - 3
SP  - 811
EP  - 822
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Miles, F. A., Laboratory of Sensorimotor Research, National Eye Institute, Building 49, Room 2 A50, 49 Convent Drive, Bethesda, MD, US, 20892-4435
N1  - Accession Number: 2008-13475-001. PMID: 9753150 Partial author list: First Author & Affiliation: Miles, F. A.; Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090112. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Eye Movements; Neural Pathways; Stereoscopic Vision; Visual Stimulation. Classification: Visual Perception (2323). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 12. Issue Publication Date: Mar, 1998. 
AB  - Primates have several reflexes that generate eye movements to compensate for bodily movements that would otherwise disturb their gaze and undermine their ability to process visual information. Two vestibulo-ocular reflexes compensate selectively for rotational and translational disturbances of the head, and each has visual backups that operate as negative feedback tracking mechanisms to deal with any residual disturbances of gaze. Of particular interest here are three recently discovered visual tracking mechanisms that specifically address translational disturbances and operate in machine-like fashion with ultra-short latencies (<60 ms in monkeys, <85 ms in humans). These visual reflexes deal with motions in all three dimensions and operate as automatic servos, using preattentive parallel processing to provide signals that initiate eye movements before the observer is even aware that there has been a disturbance. This processing is accomplished by visual filters each tuned to a different feature of the binocular images located in the immediate vicinity of the plane of fixation. Two of the reflexes use binocular stereo cues and the third is tuned to particular patterns of optic flow associated with the observer's forward motion. Some stereoanomalous subjects show tracking deficits that can be attributed to a lack of just one subtype of cortical cell encoding motion in one particular direction in a narrow depth plane centred on fixation. Despite their rapid, reflex nature, all three mechanisms rely on cortical processing and evidence from monkeys supports the hypothesis that all are mediated by the medial superior temporal (MST) area of cortex. Remarkably, MST seems to represent the first stage in cortical motion processing at which the visual error signals driving each of the three reflexes are fully elaborated at the level of individual cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - gazing
KW  - optic flow
KW  - preattentive processing
KW  - stereomechanisms
KW  - neural processing
KW  - 3-D visual information
KW  - eye movements
KW  - 1998
KW  - Eye Movements
KW  - Neural Pathways
KW  - Stereoscopic Vision
KW  - Visual Stimulation
KW  - 1998
DO  - 10.1046/j.1460-9568.1998.00112.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13475-001&site=ehost-live&scope=site
UR  - fam@lsr.nei.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Celli, Giulia
AU  - LaRochelle, William J.
AU  - Mackem, Susan
AU  - Sharp, Richard
AU  - Merlino, Glenn
T1  - Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/03/15/
VL  - 17
IS  - 6
M3  - Article
SP  - 1642
EP  - 1655
SN  - 02614189
AB  - Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes, genetic inactivation of individual genes encoding specific FGFs or their receptors (FGFRs) has generally failed to demonstrate their role in vertebrate organogenesis due to early embryonic lethality or functional redundancy. Here we show that broad mid-gestational expression of a novel secreted kinase-deficient receptor, specific for a defined subset of the FGF superfamily, caused agenesis or severe dysgenesis of kidney, lung, specific cutaneous structures, exocrine and endocrine glands, and craniofacial and limb abnormalities reminiscent of human skeletal disorders associated with FGFR mutations. Analysis of diagnostic molecular markers revealed that this soluble dominant-negative mutant disrupted early inductive signaling in affected tissues, indicating that FGF signaling is required for growth and patterning in a broad array of organs and in limbs. In contrast, transgenic mice expressing a membrane-tethered kinase-deficient FGFR were viable. Our results demonstrate that secreted FGFR mutants are uniquely effective as dominant-negative agents in vivo, and suggest that related soluble receptor isoforms expressed in wild-type mouse embryos may help regulate FGF activity during normal development. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FIBROBLAST growth factors
KW  - GENETICS
KW  - GENETIC code
KW  - MORPHOGENESIS
KW  - KIDNEYS
KW  - EMBRYOS
KW  - ORGANS (Anatomy)
KW  - dominant-negative
KW  - fgf
KW  - limb
KW  - organogenesis
KW  - transgenic mice
N1  - Accession Number: 13006115; Celli, Giulia 1 LaRochelle, William J. 2 Mackem, Susan 3 Sharp, Richard 1 Merlino, Glenn 1; Email Address: gmerlino@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  3: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 3/15/98, Vol. 17 Issue 6, p1642; Subject Term: FIBROBLAST growth factors; Subject Term: GENETICS; Subject Term: GENETIC code; Subject Term: MORPHOGENESIS; Subject Term: KIDNEYS; Subject Term: EMBRYOS; Subject Term: ORGANS (Anatomy); Author-Supplied Keyword: dominant-negative; Author-Supplied Keyword: fgf; Author-Supplied Keyword: limb; Author-Supplied Keyword: organogenesis; Author-Supplied Keyword: transgenic mice; Number of Pages: 14p; Document Type: Article
L3  - 10.1093/emboj/17.6.1642
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13006115&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Safrany, Stephen T.
AU  - Shears, Stephen B.
T1  - Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by ß2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/03/15/
VL  - 17
IS  - 6
M3  - Article
SP  - 1710
EP  - 1716
SN  - 02614189
AB  - Bis­diphosphoinositol tetrakisphosphate ([PP]2-InsP4 or ‘InsP8’) is a ‘high-energy’ inositol phosphate; we report that its metabolism is receptor-regulated in DDT1 MF-2 smooth muscle cells. This conclusion arose by pursuing the mechanism by which F­ decreased cellular levels of [PP]2-InsP4 up to 70%. A similar effect was induced by elevating cyclic nucleotide levels, either with IBMX or by application of either Bt2cAMP (EC50 = 14.7 μM), Bt2cGMP (EC50 = 7.9 μM) or isoproterenol (EC50 = 0.4 nM). Isoproterenol (1 μM) decreased [PP]2-InsP4 levels 25% by 5 min, and 71% by 60 min. This novel, agonist-mediated regulation of [PP]2-InsP4 turnover was very specific; isoproterenol did not decrease the cellular levels of either inositol pentakisphosphate, inositol hexakisphosphate or other diphosphorylated inositol polyphosphates. Bradykinin, which activated phospholipase C, did not affect [PP]2-InsP4 levels. Regulation of [PP]2-InsP4 turnover by both isoproterenol and cell-permeant cyclic nucleotides was unaffected by inhibitors of protein kinases A and G. The effectiveness of the kinase inhibitors was confirmed by their ability to block phosphorylation of the cAMP response element-binding protein. Our results indicate a new signaling action of cAMP, and furnish an important focus for future research into the roles of diphosphorylated inositol phosphates in signal transduction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INOSITOL phosphates
KW  - METABOLISM
KW  - SMOOTH muscle
KW  - CYCLIC nucleotides
KW  - ISOPROTERENOL
KW  - PHOSPHOLIPASE C
KW  - PHOSPHORYLATION
KW  - CELLULAR signal transduction
KW  - β-adrenergic
KW  - cAMP
KW  - fluoride
KW  - inositol phosphates
KW  - receptor
N1  - Accession Number: 13006109; Safrany, Stephen T. 1; Email Address: Safrany@niehs.nih.gov Shears, Stephen B. 1; Affiliation:  1: Inositide Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, PO Box 12233, NC 27709, USA; Source Info: 3/15/98, Vol. 17 Issue 6, p1710; Subject Term: INOSITOL phosphates; Subject Term: METABOLISM; Subject Term: SMOOTH muscle; Subject Term: CYCLIC nucleotides; Subject Term: ISOPROTERENOL; Subject Term: PHOSPHOLIPASE C; Subject Term: PHOSPHORYLATION; Subject Term: CELLULAR signal transduction; Author-Supplied Keyword: β-adrenergic; Author-Supplied Keyword: cAMP; Author-Supplied Keyword: fluoride; Author-Supplied Keyword: inositol phosphates; Author-Supplied Keyword: receptor; Number of Pages: 7p; Document Type: Article
L3  - 10.1093/emboj/17.6.1710
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13006109&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107271127
T1  - Persistent fatigue: a practical approach.
AU  - Hicks JE
AU  - Katon W
AU  - Natelson BH
Y1  - 1998/03/15/
N1  - Accession Number: 107271127. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0246161. 
KW  - Fatigue -- Diagnosis
KW  - Depression -- Diagnosis
KW  - Diagnosis, Differential
KW  - Diagnosis, Psychosocial
KW  - Endocrine Diseases -- Diagnosis
KW  - Fatigue Syndrome, Chronic -- Diagnosis
KW  - Female Urogenital Diseases -- Diagnosis
KW  - Gastrointestinal Diseases -- Diagnosis
KW  - Hematologic Diseases -- Diagnosis
KW  - Male Urogenital Diseases -- Diagnosis
KW  - Musculoskeletal Diseases -- Diagnosis
KW  - Patient History Taking
KW  - Sleep Disorders -- Diagnosis
SP  - 149
EP  - 162
JO  - Patient Care
JF  - Patient Care
JA  - PATIENT CARE
VL  - 32
IS  - 5
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Fatigue, one of the most common complaints in primary care practice, may be due to a broad spectrum of organic and emotional disorders. Here's how to sort out the possibilities quickly and cost-effectively.
SN  - 0031-305X
AD  - Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Md
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Diehr, Paula
AU  - Bild, Diane E.
AU  - Harris, Tamara B.
AU  - Duxbury, Andrew
AU  - Siscovick, David
AU  - Rossi, Michelle
T1  - Body Mass Index and Mortality in Nonsmoking Older Adults: The Cardiovascular Health Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/04//
VL  - 88
IS  - 4
M3  - Article
SP  - 623
EP  - 629
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study assesses the relationship of body mass index to 5-year mortality in a cohort of 4317 nonsmoking men and women aged 65 to 100 years. Methods. Logistic regression analyses were conducted to predict mortality as a function of baseline body mass index, adjusting for demographic, clinical, and laboratory covariates. Results. There was an inverse relationship between body mass index and mortality; death rates were higher for those who weighed the least. Inclusion of covariates had trivial effects on these results. People who had lost 10% or more of their body weight since age 50 had a relatively high death rate. When that group was excluded, there was no remaining relationship between body mass index and mortality. Conclusions. The association between higher body mass index and mortality often found in middle-aged populations was not observed in this large cohort of older adults. Overweight does not seem to be a risk factor for 5-year mortality in this age group. Rather, the risks associated with significant weight loss should be the primary concern. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BODY mass index
KW  - OLDER people -- Health
KW  - MORTALITY
KW  - CARDIOVASCULAR system
KW  - HUMAN body composition
N1  - Accession Number: 1137998; Diehr, Paula 1,2 Bild, Diane E. 3 Harris, Tamara B. 4 Duxbury, Andrew 5 Siscovick, David 6,7 Rossi, Michelle 8,9; Affiliation:  1: Department of Biostatistics, University of Washington, Seattle  2: Department of Health Services, University of Washington, Seattle  3: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md.  4: National Institute on Aging, Bethesda, Md.  5: Section of Geriatrics, University of California, Davis School of Medicine  6: Department of Medicine, University of Washington, Seattle  7: Department of Epidemiology, University of Washington, Seattle  8: Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pa.  9: Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pa.; Source Info: Apr98, Vol. 88 Issue 4, p623; Subject Term: BODY mass index; Subject Term: OLDER people -- Health; Subject Term: MORTALITY; Subject Term: CARDIOVASCULAR system; Subject Term: HUMAN body composition; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 5725
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107277457
T1  - The impact of mammography quality improvement legislation in Michigan: implications for the National Mammography Quality Standards Act.
AU  - Fintor L
AU  - Brown M
AU  - Fischer R
AU  - Suleiman O
AU  - Garlinghouse C
AU  - Camburn J
AU  - Frazier E
AU  - Houn F
Y1  - 1998/04//
N1  - Accession Number: 107277457. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: Behavioral Risk Factor Surveillance System (BRFSS). NLM UID: 1254074. 
KW  - Health Services Accessibility -- Legislation and Jurisprudence
KW  - Health Services Accessibility -- Standards
KW  - Mammography -- Standards
KW  - Mammography -- Trends
KW  - Mammography -- Utilization
KW  - Michigan
KW  - Attitude to Health
KW  - Quality Assurance -- Legislation and Jurisprudence
KW  - Radiographic Image Enhancement
KW  - Research Instruments
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Human
SP  - 667
EP  - 671
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 88
IS  - 4
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study examined the impact of state legislation on mammography quality and access in Michigan. METHODS: The impact of state legislation was analyzed with respect to utilization, numbers of machines and facilities, and image quality. RESULTS: The legislation had a positive effect on image quality improvement, had no impact on utilization by women aged 50 years and above, and resulted in few facility closures. CONCLUSIONS: Michigan's legislative intervention appears to have had a positive effect on efforts to improve mammography quality assurance with implications for other federal and state efforts to achieve quality assurance in health care delivery.
SN  - 0090-0036
AD  - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Md
U2  - PMID: 9551016.
DO  - 10.2105/AJPH.88.4.667
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107277457&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107272651
T1  - ERT for endometrial cancer survivors?
AU  - Trimble EL
Y1  - 1998/04//1998 Apr
N1  - Accession Number: 107272651. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0367022. 
KW  - Endometrial Neoplasms
KW  - Hormone Replacement Therapy
KW  - Risk Factors
KW  - Female
SP  - 160
EP  - 164
JO  - Contemporary OB/GYN
JF  - Contemporary OB/GYN
JA  - CONTEMP OB GYN
VL  - 43
IS  - 4
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Three retrospective studies suggest that survivors of endometrial cancer might consider ERT after treatment. Now obstetrician-gynecologists can help the Gynecologic Oncology Group find more definitive answers through an important new, nationwide study to gauge the safety of this approach.
SN  - 0090-3159
AD  - Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute, Bethesda, Md
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107272651&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
T1  - Assessments of Children's Credibility in Forensic Contexts.
JO  - Current Directions in Psychological Science
JF  - Current Directions in Psychological Science
Y1  - 1998/04//
VL  - 7
IS  - 2
M3  - Article
SP  - 43
EP  - 46
PB  - Sage Publications Inc.
SN  - 09637214
AB  - Focuses on the necessity for forensic psychologists to develop and validate techniques for evaluating the competence and credibility of young witnesses. Increase in the number of allegations of children on sexual abuse; Criteria for the quantification of the credibility of children's accounts; Potential weakness of the criterion-based content analysis.  INSET: Recommended Reading.
KW  - TRUTHFULNESS & falsehood
KW  - WITNESSES
KW  - SEX crimes
KW  - CHILD witnesses
KW  - COMPLAINTS (Civil procedure)
KW  - FORENSIC psychologists
KW  - FORENSIC psychology
N1  - Accession Number: 13175602; Lamb, Michael E. 1; Email Address: michael_lamb@nih.gov; Affiliation:  1: Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, Maryland; Source Info: Apr98, Vol. 7 Issue 2, p43; Subject Term: TRUTHFULNESS & falsehood; Subject Term: WITNESSES; Subject Term: SEX crimes; Subject Term: CHILD witnesses; Subject Term: COMPLAINTS (Civil procedure); Subject Term: FORENSIC psychologists; Subject Term: FORENSIC psychology; Number of Pages: 4p; Document Type: Article
L3  - 10.1111/1467-8721.ep13175602
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13175602&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107264490
T1  - Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: the Third National Health and Nutrition Examination Survey, 1988-1994.
AU  - Harris MI
AU  - Flegal KM
AU  - Cowie CC
AU  - Eberhardt MS
AU  - Goldstein DE
AU  - Little RR
AU  - Wiedmeyer HM
AU  - Byrd-Holt DD
Y1  - 1998/04//
N1  - Accession Number: 107264490. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Diabetes Mellitus -- Epidemiology -- United States
KW  - Glucose Intolerance -- Epidemiology -- United States
KW  - Survey Research
KW  - United States
KW  - Interviews
KW  - Random Assignment
KW  - Glucose Tolerance Test
KW  - Data Analysis Software
KW  - Data Analysis, Statistical
KW  - Descriptive Statistics
KW  - Cross Sectional Studies
KW  - Epidemiological Research
KW  - Race Factors
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 518
EP  - 524
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 21
IS  - 4
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To evaluate the prevalence and time trends for diagnosed and undiagnosed diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults by age, sex, and race or ethnic group, based on data from the Third National Health and Nutrition Examination Survey, 1988-1994 (NHANES III) and prior Health and Nutrition Examination Surveys (HANESs). RESEARCH DESIGN AND METHODS: NHANES III contained a probability sample of 18,825 U.S. adults > or = 20 years of age who were interviewed to ascertain a medical history of diagnosed diabetes, a subsample of 6,587 adults for whom fasting plasma glucose values were obtained, and a subsample of 2,844 adults between 40 and 74 years of age who received an oral glucose tolerance test. The Second National Health and Nutrition Examination Survey, 1976-1980, and Hispanic HANES used similar procedures to ascertain diabetes. Prevalence was calculated using the 1997 American Diabetes Association fasting plasma glucose criteria and the 1980-1985 World Health Organization (WHO) oral glucose tolerance test criteria. RESULTS: Prevalence of diagnosed diabetes in 1988-1994 was estimated to be 5.1% for U.S. adults > or = 20 years of age (10.2 million people when extrapolated to the 1997 U.S. population). Using American Diabetes Association criteria, the prevalence of undiagnosed diabetes (fasting plasma glucose > or = 126 mg/dl) was 2.7% (5.4 million), and the prevalence of impaired fasting glucose (110 to < 126 mg/dl) was 6.9% (13.4 million). There were similar rates of diabetes for men and women, but the rates for non-Hispanic blacks and Mexican-Americans were 1.6 and 1.9 times the rate for non-Hispanic whites. Based on American Diabetes Association criteria, prevalence of diabetes (diagnosed plus undiagnosed) in the total population of people who were 40-74 years of age increased from 8.9% in the period 1976-1980 to 12.3% by 1988-1994. A similar increase was found when WHO criteria were applied (11.4 and 14.3%). CONCLUSIONS: The high rates of abnormal fasting and postchallenge glucose found in NHANES III, together with the increasing frequency of obesity and sedentary lifestyles in the population, make it likely that diabetes will continue to be a major health problem in the U.S.
SN  - 0149-5992
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
U2  - PMID: 9571335.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107264490&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Matsumoto, Ken
AU  - Wassarman, Karen Montzka
AU  - Wolffe, Alan P.
T1  - Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/04//4/1/98
VL  - 17
IS  - 7
M3  - Article
SP  - 2107
EP  - 2121
SN  - 02614189
AB  - The pathways of synthesis and maturation of pre-messenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of intron­less mRNA in vivo directs this mRNA towards translational silencing. The presence of an intron at the 5′ end of the transcript relieves this silencing, whereas an intron at the 3 end further represses translation. These regulatory events are strongly dependent on the transcription of pre-mRNA in the nucleus. The impact of nuclear history on regulatory events in the cytoplasm provides a novel mechanism for the control of gene expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MESSENGER RNA
KW  - CYTOPLASM
KW  - INTRONS
KW  - GENE expression
KW  - nuclear compartments
KW  - ribonuclear protein
KW  - splicing control
KW  - transcriptional control
KW  - translational control
N1  - Accession Number: 13006130; Matsumoto, Ken 1,2 Wassarman, Karen Montzka 1 Wolffe, Alan P. 1; Email Address: awlme@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Building 18T, Bethesda, MD, USA  2: Laboratory of Bioorganic Chemistry, The Institute of Physical and Chemical Research, Hirosawa 2-1, Wako-shi,Saitama 351-01, Japan; Source Info: 4/1/98, Vol. 17 Issue 7, p2107; Subject Term: MESSENGER RNA; Subject Term: CYTOPLASM; Subject Term: INTRONS; Subject Term: GENE expression; Author-Supplied Keyword: nuclear compartments; Author-Supplied Keyword: ribonuclear protein; Author-Supplied Keyword: splicing control; Author-Supplied Keyword: transcriptional control; Author-Supplied Keyword: translational control; Number of Pages: 15p; Document Type: Article
L3  - 10.1093/emboj/17.7.2107
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sedmera, David D.
AU  - Pexieder, Tomas T.
AU  - Hu, Norman N.
AU  - Clark, E.B.
T1  - A Quantitative Study of the Ventricular Myoarchitecture in the Stage 21–29 Chick Embryo Following Decreased Loading.
JO  - European Journal of Morphology
JF  - European Journal of Morphology
Y1  - 1998/04//
VL  - 36
IS  - 2
M3  - Article
SP  - 105
EP  - 119
PB  - Taylor & Francis Ltd
SN  - 09243860
AB  - During the early developmental period, ventricular myoarchitecture undergoes a transition from a smooth-walled cardiac tube, to left and right ventricular chambers filled with a sponge-like network of trabecular struts. We measured the quantitative changes of ventricular myocardium properties in normal stage 21–29 chick embryos and after chronic verapamil suffusion, which is known to decrease work load and decelerate ventricular growth. The morphologic parametres (compact layer thickness, ventricular wall composition, porosity of different layers and trabecular orientation) were determined from scanning electron micrographs of transversely dissected perfusion-fixed hearts. A vascular bed of stage 21 chick embryos was suffused with 1 ng of verapamil at 1 µl per hour up to stages 24, 27 and 29 via a miniosmotic pump. From stage 24, the thickness of the compact myocardium in the left ventricle was greater than that of the right. The increase in thickness was minimal between stages 24 and 27, while the predominantly radially arranged trabeculae comprised up to 75% of total myocardial mass. The ratio of intertrabecular spaces to trabeculae (local porosity) decreased from the ventricular center (70%) towards the compact myocardium (0%). In verapamil-treated embryos, the hearts were smaller and showed delayed development. The compact myocardium was thinner than normal, and the proportion of trabeculae was higher than in controls. The local porosity values were similar in control and experimental groups. Decreased load resulted in delayed growth and morphogenesis, expressed as a persistence of trabeculae and a thinner compact myocardium. Embryonic heart pumping function is largely based on extensively developed trabeculation with regionally different properties. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Morphology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MYOCARDIUM -- Physiology
KW  - CHICKEN embryos
KW  - HEART -- Physiology
KW  - chronic verapamil suffusion
KW  - Compact myocardium
KW  - image analysis
KW  - perfusion-fixation
KW  - Trabecular orientation
N1  - Accession Number: 5791853; Sedmera, David D. 1,2 Pexieder, Tomas T. 1 Hu, Norman N. 3 Clark, E.B. 3; Affiliation:  1: University of Lausanne, Institute of Histology and Embryology,, Lausanne, Switzerland  2: University of Lausanne, Institute of Physiology, Rue du Bugnon 7,, Lausanne, CH-1005, Switzerland  3: University of Rochester School of Medicine & Dentistry, National Institutes of Health, Specialized Center of Research in Pediatric Cardiovascular Diseases, Department of Pediatrics,, New York, NY 14642, USA; Source Info: Apr98, Vol. 36 Issue 2, p105; Subject Term: MYOCARDIUM -- Physiology; Subject Term: CHICKEN embryos; Subject Term: HEART -- Physiology; Author-Supplied Keyword: chronic verapamil suffusion; Author-Supplied Keyword: Compact myocardium; Author-Supplied Keyword: image analysis; Author-Supplied Keyword: perfusion-fixation; Author-Supplied Keyword: Trabecular orientation; Number of Pages: 15p; Illustrations: 3 Black and White Photographs, 4 Diagrams, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - GEN
AU  - White Riley, Matilda
AU  - Kahn, Robert L.
AU  - Rowe, John W.
T1  - Successful aging.
JO  - Gerontologist
JF  - Gerontologist
Y1  - 1998/04//
VL  - 38
IS  - 2
M3  - Letter
SP  - 151
EP  - 151
SN  - 00169013
AB  - A letter to the editor is presented in response to the August 1997 article "Successful Aging," by John Rowe and Robert Kahn on the methodology for intervention studies of population aging research, with a written reply from the authors on structural intervention in gerontological research and social theory.
KW  - GERONTOLOGY research
KW  - POPULATION aging
KW  - AGING -- Research
KW  - OLDER people
KW  - RESEARCH
KW  - AGING -- Social aspects
N1  - Accession Number: 92555186; White Riley, Matilda 1 Kahn, Robert L. 2 Rowe, John W. 3; Affiliation:  1: National Institutes of Health, National Institute on Aging, Bethesda, Maryland  2: Institute for Social Research, University of Michigan, Ann Arbor  3: Mount Sinai Medical Center, New York; Source Info: Apr98, Vol. 38 Issue 2, p151; Subject Term: GERONTOLOGY research; Subject Term: POPULATION aging; Subject Term: AGING -- Research; Subject Term: OLDER people; Subject Term: RESEARCH; Subject Term: AGING -- Social aspects; Number of Pages: 1p; Document Type: Letter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 88362900
T1  - Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group.
AU  - Heerema, Nyla A.
AU  - Sather, Harland N.
AU  - Sensel, Martha G.
AU  - Kraft, Peter
AU  - Nachman, James B.
AU  - Steinherz, Peter G.
AU  - Lange, Beverly J.
AU  - Hutchinson, Raymond S.
AU  - Reaman, Gregory H.
AU  - Trigg, Michael E.
AU  - Arthur, Diane C.
AU  - Gaynon, Paul S.
AU  - Uckun, Fatih M.
AU  - Heerema, N A
AU  - Sather, H N
AU  - Sensel, M G
AU  - Kraft, P
AU  - Nachman, J B
AU  - Steinherz, P G
AU  - Lange, B J
Y1  - 1998/04//
N1  - Accession Number: 88362900. Language: English. Entry Date: 19980601. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins); Longitudinal Interval Follow-Up Evaluation (LIFE). Grant Information: CA-60437/CA/NCI NIH HHS/United States. NLM UID: 8309333. 
KW  - Chromosome Aberrations
KW  - Lymphoma, T-Cell
KW  - Prognosis
KW  - Male
KW  - Lymphoma, T-Cell -- Classification
KW  - Female
KW  - Child
KW  - Adolescence
KW  - Life Table Method
KW  - Genetics
KW  - Karyotyping
KW  - Child, Preschool
KW  - Prospective Studies
KW  - Infant
KW  - Human
KW  - Immunophenotyping
KW  - Chromosome Disorders
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Scales
SP  - 1270
EP  - 1278
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 4
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: Nonrandom chromosomal translocations are frequently observed in pediatric patients with acute lymphoblastic leukemia (ALL). Specific translocations, such as t(4;11) and t(9;22), identify subgroups of B-lineage ALL patients who have an increased risk of treatment failure. The current study was conducted to determine the prognostic significance of chromosomal translocations in T-lineage ALL patients.Materials and Methods: The study included 169 children with newly diagnosed T-lineage ALL enrolled between 1988 and 1995 on risk-adjusted protocols of the Children's Cancer Group (CCG) who had centrally reviewed cytogenetics data. Outcome analyses used standard life-table methods.Results: Presenting features for the current cohort were similar to those of concurrently enrolled patients for whom cytogenetic data were not accepted on central review. The majority of patients (80.5%) were assigned to CCG protocols for high-risk ALL and 86.4% had pseudodiploid (n = 80) or normal diploid (n = 66) karyotypes; modal chromosome number was not a significant prognostic factor. Overall, 103 of 169 (61%) patients had an abnormal karyotype, including 31 with del(6q), 29 with 14q11 breakpoints, 15 with del(9p), 11 with trisomy 8, nine with 11q23 breakpoints, nine with 14q32 translocations, and eight with 7q32-q36 breakpoints. Thirteen patients had the specific 14q11 translocation t(11;14)(p13;q11) and all were classified as poor risk. Patients with any of these translocations had outcomes similar to those with normal diploid karyotypes.Conclusion: Chromosomal abnormalities, including specific nonrandom translocations, were frequently observed in a large group of children with T-lineage ALL, but were not significant prognostic factors for this cohort. Thus, contemporary intensive treatment programs result in favorable outcomes for the majority of T-lineage ALL patients, regardless of karyotypic abnormalities, and such features do not identify patients at higher risk for relapse.
SN  - 0732-183X
AD  - Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN
AD  - Department of Preventive Medicine, University of Southern California, Los Angeles
AD  - Group Operations Center Children's Cancer Group, Arcadia, CA
AD  - Department of Pediatric Hematology-Oncology, University of Chicago, Chicago, IL
AD  - Department of Pediatrics, Memorial Sloan-Kettering Cancer Center New York, NY
AD  - Division of Oncology, Children's Hospital of Philadelphia, PA
AD  - Department of Pediatric Hematology-Oncology, University of Michigan, Ann Arbor, MI
AD  - Department of Hematology-Oncology, Children's National Medical Center and George Washington University, Washington, DC
AD  - Division of Bone Marrow Transplantation, University of Iowa Hospital and Clinics, Iowa City, IA
AD  - Department of Clinical Cytogenetics, Laboratory of Pathology, National Cancer Institute, Bethesda, MD
AD  - Department of Pediatric Hematology-Oncology, University of Wisconsin, Madison, WI
AD  - Children's Cancer Group Acute Lymphoblastic Leukemia Biology Reference Lab and Wayne Hughes Institute, St Paul, MN
AD  - Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5251, USA
U2  - PMID: 9552025.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88362930
T1  - Isolated hepatic perfusion with tumor necrosis factor and melphalan for unresectable cancers confined to the liver.
AU  - Alexander Jr., H. Richard
AU  - Bartlett, David L.
AU  - Libutti, Steven K.
AU  - Fraker, Douglas L.
AU  - Moser, Tammy
AU  - Rosenberg, Steven A.
AU  - Alexander, H R Jr
AU  - Bartlett, D L
AU  - Libutti, S K
AU  - Fraker, D L
AU  - Moser, T
AU  - Rosenberg, S A
Y1  - 1998/04//
N1  - Accession Number: 88362930. Language: English. Entry Date: 19980601. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Tumor Necrosis Factor -- Administration and Dosage
KW  - Liver Neoplasms -- Therapy
KW  - Antineoplastic Agents, Alkylating -- Administration and Dosage
KW  - Melphalan -- Administration and Dosage
KW  - Chemotherapy, Cancer -- Methods
KW  - Antineoplastic Agents, Alkylating -- Adverse Effects
KW  - Aminotransferases -- Metabolism
KW  - Male
KW  - Human
KW  - Melphalan -- Adverse Effects
KW  - Liver Neoplasms
KW  - Adult
KW  - Middle Age
KW  - Tumor Necrosis Factor -- Adverse Effects
KW  - Treatment Outcomes
KW  - Female
KW  - Aged
KW  - Neoplasm Recurrence, Local
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 1479
EP  - 1489
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 4
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To evaluate the efficacy and systemic and regional toxicities of hyperthermic isolated hepatic perfusion (IHP) using tumor necrosis factor (TNF) and melphalan for the treatment of unresectable primary or metastatic cancers confined to the liver.Patients and Methods: Thirty-four patients (18 men and 16 women; mean age, 49 years) underwent a 60-minute hyperthermic (39.5 degrees to 40.0 degrees C) IHP performed by laparotomy that used TNF 1.0 mg and melphalan 1.5 mg/kg. Perfusion inflow was through the gastroduodenal artery and outflow was from a cannula positioned in an isolated segment of retrohepatic inferior vena cava (IVC). Infrahepatic IVC and portal venous blood flow were shunted to the axillary vein using an external venoveno bypass circuit. Complete vascular isolation of the liver was confirmed by an I-131-labelled human serum albumin monitoring technique.Results: There was no operative mortality. Seventy-five percent of patients had reversible grade III or IV (National Cancer Institute Common Toxicity Criteria) hepatic toxicity with one treatment-related mortality (3%) because of hepatic venoocclusive disease. In 33 assessable patients, the overall response rate was 75% (complete response, one patient [3%]; partial response, 26 patients [72%]). With a median potential follow-up of 15 months, the mean duration of response was 9 months (range, 2 to 30 months).Conclusion: IHP with TNF and melphalan results in significant regression of bulky hepatic cancers confined to the liver in the majority of patients. Based on these initial results, further refinement of this treatment technique is warranted; perhaps by the combination of IHP with other regional treatment strategies to provide long-term control of unresectable cancers confined to liver.
SN  - 0732-183X
AD  - Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
AD  - Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1502, USA
U2  - PMID: 9552055.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hser, Yih-Ing
AU  - Boyle, Kathleen
AU  - Anglin, M. Douglas
T1  - DRUG USE AND CORRELATES AMONG SEXUALLY TRANSMITTED DISEASE PATIENTS, EMERGENCY ROOM PATIENTS, AND ARRESTEES.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1998///Spring98
VL  - 28
IS  - 2
M3  - Article
SP  - 437
EP  - 454
SN  - 00220426
AB  - This paper reports the results of a study on the use of illicit drugs and related problems in groups that are often considered hidden populations at high risk for drug abuse. Face-to-face interviews were conducted in 1992-94 with 5,168 subjects from sexually transmitted disease (STD) clinics, hospital emergency rooms (ER), and jails in Los Angeles County, California. Extensive drug involvement and other HIV-risk behaviors were reported by all three samples. Excluding marijuana, crack and cocaine were the most prevalent drugs used; the rate of positive cocaine urinalysis was 8.5% for STD subjects, 18.1% for ER subjects, and 52.8% for the arrestees. About 40% of the subjects from both STDs and jails and 27% from ERs reported three or more sex partners in the past year. About 41% of SID and 49% of ER samples also reported having arrest records. Current use of heroin and cocaine was highly associated with multiple sex partners and an arrest record. The study confirmed the high prevalence of drug abuse and other high-risk behaviors in these samples. The importance of targeting these groups for early identification and intervention is underscored. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse
KW  - SEXUALLY transmitted diseases
KW  - PATIENTS
KW  - HOSPITAL patients
KW  - PRISONERS
KW  - MARIJUANA
KW  - DRUGS of abuse
KW  - INTERVENTION (Criminal procedure)
KW  - INTERVIEWS
KW  - CALIFORNIA
N1  - Accession Number: 876908; Hser, Yih-Ing 1,2 Boyle, Kathleen 3 Anglin, M. Douglas 4,5; Affiliation:  1: Adjunct Professor and Associate Director, University of California, Los Angeles (UCLA) Drug Abuse Research Center  2: Principal Investigator of National Institute on Drug Abuse  3: Arrestee Drug Abuse Monitoring project's Los Angeles site  4: Director of the UCLA Drug Abuse Research Center  5: Professor in Residence of Medical Psychology, Department of Psychiatry and Biobehavioral Sciences; Source Info: Spring98, Vol. 28 Issue 2, p437; Subject Term: DRUG abuse; Subject Term: SEXUALLY transmitted diseases; Subject Term: PATIENTS; Subject Term: HOSPITAL patients; Subject Term: PRISONERS; Subject Term: MARIJUANA; Subject Term: DRUGS of abuse; Subject Term: INTERVENTION (Criminal procedure); Subject Term: INTERVIEWS; Subject Term: CALIFORNIA; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; Number of Pages: 17p; Illustrations: 7 Charts; Document Type: Article; Full Text Word Count: 6113
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Bond, Michael H.
AU  - Yik, Michelle S. M.
AU  - Trapnell, Paul D.
AU  - Paulhus, Delroy L.
T1  - Interpreting Personality Profiles Across Cultures: Bilingual, Acculturation, and Peer Rating Studies of Chinese Undergraduates.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1998/04//
VL  - 74
IS  - 4
M3  - Article
SP  - 1041
EP  - 1055
SN  - 00223514
AB  - Prior research (R. R. McCrae, P. T. Costa, & M. S. M. Yik, 1996) using a Chinese translation of the Revised NEO Personality Inventory suggested substantial differences between Hong Kong and North American undergraduates. Study 1, with a sample of bilingual Hong Kong students (N = 162), showed that prior findings were not due simply to the translation. Study 2, with undergraduates of European and Chinese ancestry living in Canada (N = 633), suggested that most of the differences were cultural in origin. Study 3, which used peer ratings of Chinese students (N = 99), replicated most Study 2 results, suggesting that exposure to Canadian culture increased openness, cheerfulness, and prosocial behavior and attitudes. Differences in sense of competence and vulnerability to stress appeared to be due to different cultural standards for judging these traits. Together, the 3 studies illustrate an integrated approach to interpreting personality differences across cultures. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY & culture
KW  - NEO Personality Inventory
KW  - PERSONALITY tests
KW  - AGE groups
KW  - ETHNOPSYCHOLOGY
N1  - Accession Number: 534875; McCrae, Robert R. 1; Email Address: jeffm@mvx.grc.nia.nih.gov Bond, Michael H. 2 Yik, Michelle S. M. 3 Trapnell, Paul D. 3 Paulhus, Delroy L. 3; Affiliation:  1: Gerontology Research Center, National Institute on Aging, National Institutes of Health  2: Chinese University of Hong Kong  3: University of British Columbia; Source Info: Apr98, Vol. 74 Issue 4, p1041; Subject Term: PERSONALITY & culture; Subject Term: NEO Personality Inventory; Subject Term: PERSONALITY tests; Subject Term: AGE groups; Subject Term: ETHNOPSYCHOLOGY; Number of Pages: 15p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sakamoto, Shinji
AU  - Kambara, Masashiko
T1  - A Longitudinal Study of the Relationship Between Attributional Style, Life Events, and Depression in Japanese Undergraduates.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1998/04//
VL  - 138
IS  - 2
M3  - Article
SP  - 229
EP  - 240
PB  - Taylor & Francis Ltd
SN  - 00224545
AB  - The article investigates the relationship between attributional style, life events, and depression in Japanese undergraduates. It is based on the following hypotheses: among the participants experiencing negative events, those with a depressogenic attributional style will be more depressed than those with a nondepressogenic attributional style; and among the participants experiencing positive events, those with an enhancing, attributional style will be less depressed than those with a nonenhancing attributional style. A total of 143 undergraduates responded to a depression scale, a life event questionnaire, and an attributional style questionnaire. Depressive reactions were more strongly predicted by the interaction between positive events and an enhancing attributional style than by the interaction between negative events and a. depressogenic attributional style report- ed by researchers in the United States. The self-enhancing effect of attributing success to oneself might be greater in Japan than in the United States.
KW  - DEPRESSION in men
KW  - MENTAL depression
KW  - FEAR of success
KW  - AMBITION
KW  - SOCIAL psychology
KW  - JAPAN
N1  - Accession Number: 420510; Sakamoto, Shinji 1 Kambara, Masashiko 2; Affiliation:  1: Department of Sociocultural Environmental Research National Institute of Mental Health, National Center of Neurology and Psychiatry Ichikawa, Chiba, Japan.  2: Department of Psychology, Faculty of Letters Teikyo University, Tokyo, Hachioji, Japan.; Source Info: Apr1998, Vol. 138 Issue 2, p229; Subject Term: DEPRESSION in men; Subject Term: MENTAL depression; Subject Term: FEAR of success; Subject Term: AMBITION; Subject Term: SOCIAL psychology; Subject Term: JAPAN; Number of Pages: 12p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 4455
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kumra, Sanjiv
AU  - Jacobsen, Leslie K.
AU  - Lenane, Marge
AU  - Karp, Barbara I.
AU  - Frazier, Jean A.
AU  - Smith, Amy K.
AU  - Bedwell, Jeffrey
AU  - Lee, Paul
AU  - Malanga, C. J.
AU  - Hamburger, Susan
AU  - Rapoport, Judith L.
AU  - Kumra, S
AU  - Jacobsen, L K
AU  - Lenane, M
AU  - Karp, B I
AU  - Frazier, J A
AU  - Smith, A K
AU  - Bedwell, J
AU  - Lee, P
AU  - Hamburger, S
T1  - Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents.
JO  - Journal of the American Academy of Child & Adolescent Psychiatry
JF  - Journal of the American Academy of Child & Adolescent Psychiatry
Y1  - 1998/04//
VL  - 37
IS  - 4
M3  - journal article
SP  - 377
EP  - 385
SN  - 08908567
AB  - <bold>Objective: </bold>Olanzapine, a potent 5-HT2a/2c, dopamine D1D2D4 antagonist with anticholinergic activity, has a profile of known receptor affinity similar to that of clozapine. This pilot study examined the efficacy of olanzapine for treatment-refractory childhood-onset schizophrenia in eight patients who had received 8-week open-label trials. For comparison, data are included from 15 patients who had received 6-week open-label clozapine trials using identical rating instruments (largely by the same raters) in the same treatment setting.<bold>Method: </bold>Twenty-three children and adolescents with an onset of DSM-III-R schizophrenia by age 12 for whom at least two different typical neuroleptics had been ineffective participated in the two separate studies. Some of the patients were intolerant of clozapine, although it had been effective (n = 4). Patients receiving olanzapine were evaluated over 8 weeks with the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, and the Clinical Global Impressions Scale for Improvement.<bold>Results: </bold>For the eight patients who received olanzapine trials, at week 8 there was a 17% improvement in the BPRS total score, a 27% improvement in the Scale for the Assessment of Negative Symptoms, and a 1% improvement in the Scale for the Assessment of Positive Symptoms, relative to "ideal" admission status on typical neuroleptics. In contrast, the magnitude of the effect sizes for each of the clinical ratings was larger at week 6 of the previous clozapine trial than for an 8-week olanzapine trial, relative to admission status on typical neuroleptics. For the four children who had received both clozapine and olanzapine, BPRS total scores were significantly lower at week 6 of clozapine treatment compared with week 6 of olanzapine treatment (p = .03).<bold>Conclusion: </bold>These data provide preliminary evidence for the efficacy of olanzapine for some children and adolescents with treatment-refractory schizophrenia, but they also suggest the need for a more rigorous double-blind comparison of these two atypical antipsychotics. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SCHIZOPHRENIA in children
KW  - OLANZAPINE
N1  - Accession Number: 444143; Kumra, Sanjiv Jacobsen, Leslie K. Lenane, Marge Karp, Barbara I. Frazier, Jean A. Smith, Amy K. Bedwell, Jeffrey Lee, Paul Malanga, C. J. Hamburger, Susan Rapoport, Judith L. Kumra, S 1 Jacobsen, L K Lenane, M Karp, B I Frazier, J A Smith, A K Bedwell, J Lee, P Hamburger, S; Affiliation:  1: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA; Source Info: Apr98, Vol. 37 Issue 4, p377; Subject Term: SCHIZOPHRENIA in children; Subject Term: OLANZAPINE; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107269386
T1  - Best practice. Doing more with less: using silent in-services for staff development.
AU  - Lance R
AU  - Clavell LE
AU  - Fischer S
AU  - Link ME
AU  - O'Dell WS
Y1  - 1998/04//1998 Apr
N1  - Accession Number: 107269386. Language: English. Entry Date: 19980701. Revision Date: 20150819. Publication Type: Journal Article; pictorial; questionnaire/scale; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9300545. 
KW  - Staff Development -- Methods
KW  - Education, Nursing, Continuing
KW  - Self Directed Learning
KW  - Teaching Methods, Clinical
KW  - Nursing Staff, Hospital -- Education
KW  - Professional Development
KW  - Staff Development -- Economics
KW  - Information Needs
KW  - Needs Assessment
KW  - Questionnaires
KW  - Committees
KW  - Cost Benefit Analysis
SP  - 91
EP  - 98
JO  - MEDSURG Nursing
JF  - MEDSURG Nursing
JA  - MEDSURG NURS
VL  - 7
IS  - 2
CY  - Pitman, New Jersey
PB  - Jannetti Publications, Inc.
AB  - A unit's greatest asset is nurses who are up-to-date in their practice. Time and money constraints demand innovative and creative educational methods. Silent in-services teach and empower while encompassing multiple learning styles in a cost-efficient manner.
SN  - 1092-0811
AD  - Clinical Nurse III, National Institutes of Health, Bethesda, MD
U2  - PMID: 9727123.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Stoner, G.L.
AU  - Agostini, H.T.
AU  - Ryschkewitsch, C.F.
AU  - Komoly, S.
T1  - JC virus excreted by multiple sclerosis patients and paired controls from Hungary.
JO  - Multiple Sclerosis (13524585)
JF  - Multiple Sclerosis (13524585)
Y1  - 1998/04//
VL  - 4
IS  - 2
M3  - Article
SP  - 45
EP  - 48
PB  - Sage Publications, Ltd.
SN  - 13524585
AB  - JC virus (JCV), a human polyomavirus, is the agent of the demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV exists in four main genotypes in the USA. Type 1, including subtypes Type 1A and Type 1B, makes up about 64% of strains in the USA and is thought to be of European origin. Type 2 is found in Asia, and Type 3 in Africa. A fourth type is found only in the USA. In general, these genotypes differ in 1 – 2.5% of their DNA sequence. Thirty MS patients and 30 paired controls from Budapest were studied. The clinical course of MS was mainly secondary progressive, and patients were stable at the time of testing. Most of the controls were relatives of the probands: a spouse, parent, or child. Overall, 25 of 60 (42%) of the urines tested positive for JCV by PCR. These included 13 of 30 MS patients, and 12 of 30 controls. Genotyping in the VP1 gene showed all 25 JCV strains to be Type 1. Among the MS patients, seven were Type 1A and six were Type 1B. Among the controls, nine were Type 1A and three were Type 1B. In five pairs of MS patients and controls, both were positive for JCV by PCR. Two of these were husband/wife pairs of which one pair was matched for subtype (both Type 1A), and the other was not. Two of them were mother/daughter pairs, and both were matched for subtype (both Type 1B). These findings demonstrate that JCV Type 1 predominates among Hungarians, and suggest that parent/child pairs can be used to trace JCV transmission within the MS family. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Multiple Sclerosis (13524585) is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VIRUSES
KW  - MULTIPLE sclerosis
KW  - PATHOLOGICAL physiology
KW  - demyelination
KW  - genotype
KW  - polyomavirus
KW  - urine
N1  - Accession Number: 5004052; Stoner, G.L. 1 Agostini, H.T. 1 Ryschkewitsch, C.F. 1 Komoly, S. 2; Affiliation:  1: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Neurotoxicology Section, Bethesda, Maryland 20892, USA  2: Jahn Ferenc Dél-Pesti Teaching Hospital, Department of Neurology, Budapest, Hungary; Source Info: Apr98, Vol. 4 Issue 2, p45; Subject Term: VIRUSES; Subject Term: MULTIPLE sclerosis; Subject Term: PATHOLOGICAL physiology; Author-Supplied Keyword: demyelination; Author-Supplied Keyword: genotype; Author-Supplied Keyword: polyomavirus; Author-Supplied Keyword: urine; Number of Pages: 4p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Griffin, Robert J.
AU  - Godfrey, Veronica B.
AU  - Burka, Leo T.
T1  - Metabolism and Disposition of Phenolphthalein in Male and Female F344 Rats and B6C3F1 Mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/04//
VL  - 42
IS  - 2
M3  - Article
SP  - 73
EP  - 81
SN  - 10966080
AB  - A recent 2-year carcinogenicity/toxicology study determined that phenolphthalein (PHTH) is a multisite carcinogen in both mice and rats at all doses evaluated. In response to this finding the metabolism and disposition of PHTH has been evaluated in both F344 rats and B6C3F1 mice at a single oral dose of 800 mg/kg. This dose fell within the range previously found to be carcinogenic in rats and mice. Studies were also performed using 1 and 50 mg/kg doses. At 800 mg/kg recovery of [14C]PHTH after 72 h was near 100% in females but closer to 75% in males. Radioactivity was primarily recovered in the feces in rats (>90%), while mice excreted 30–40% of administered activity in the urine. There was no significant retention of radioactivity in tissues by 72 h and no significant accumulation of radioactivity in any tissue at any time point. Covalent binding to protein in target tissues, bone marrow and ovary, was at or less than the pmol/mg protein range. The major metabolite was PHTH glucuronide. Three minor metabolites were detected. A sulfate conjugate and and a hydroxylated metabolite were identified by comparison of retention times and 1H NMR and/or mass spectra with synthetic standards. A diglucuronide conjugate was tentatively identified. Biliary elimination was extensive in rats (35% of dose within 6 h); the only product detected in bile was phenolphthalein glucuronide. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83181098; Griffin, Robert J. 1; Godfrey, Veronica B. 1; Burka, Leo T. 1; Affiliations: 1: National Institute of Environmental Health Sciences, National Toxicology Program Research Triangle Park, North Carolina 27709; Issue Info: 1998, Vol. 42 Issue 2, p73; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Abdo, Kamal M.
AU  - Haseman, Joseph K.
AU  - Nyska, Abraham
T1  - Isobutyraldehyde Administered by Inhalation (Whole Body Exposure) for up to Thirteen Weeks or Two Years Was a Respiratory Tract Toxicant but Was Not Carcinogenic in F344/N Rats and B6C3F1 Mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/04//
VL  - 42
IS  - 2
M3  - Article
SP  - 136
EP  - 151
SN  - 10966080
AB  - Isobutyraldehyde (a chemical structurally related to formaldehyde and used as a flavoring agent) was studied for toxicity and carcinogenicity by exposing male and female F344/N rats and B6C3F1 mice. Animals were exposed to isobutyraldehyde vapors 6 h per day, 5 days per week for up to 13 weeks or 2 years. In the 13-week studies, groups of 10 male and 10 female F344/N rats and B6C3F1 mice were exposed to concentrations of 0, 500, 1000, 2000, 4000, or 8000 ppm. Chemical-related body weight depression and deaths occurred in rats and mice exposed to 4000 and 8000 ppm. Necrosis of the epithelium accompanied with acute inflammatory reaction was observed in the nasal turbinate, larynx, and trachea of rats exposed to 8000 ppm. Exposure of rats to 4000 ppm resulted in metaplasia of the nasal respiratory epithelium, inflammation, degeneration of the olfactory epithelium, and osteodystrophy of the nasal turbinate bone. In the 13-week mouse study, exposure to 8000 ppm or 4000 ppm resulted in necrosis of the epithelium lining of the nasal turbinates. Osteodystrophy of the nasal turbinate bone and squamous metaplasia of the nasal respiratory epithelium were noted in mice exposed 4000 ppm. Degeneration of the olfactory epithelium was noted in males exposed 2000 ppm and in females exposed to 4000 ppm. In the 2-year studies, groups of 50 male and 50 male F344/N rats and B6C3F1 were exposed to concentrations isobutyraldehyde vapors of 0, 500, 1000, or 2000 ppm 6 h per day, 5 days per week. There were no differences in survival rates or mean body weights between exposed groups and control rats. Survival of male mice exposed to 2000 ppm and mean body weights of female mice exposed to 1000 or 2000 ppm were lower than those of the of the controls. No increase in neoplasm incidence was observed in rats and mice in the 2-year studies that could be attributed to isobutyraldehyde exposure. Chemical-related nonneoplastic lesions were limited to the nose of rats and mice. They included squamous metaplasia of the respiratory epithelium (rats), suppurative inflammation (rats), and olfactory epithelial degeneration (rats and mice) at 1000 and 2000 ppm. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83181094; Abdo, Kamal M. 1; Haseman, Joseph K. 1; Nyska, Abraham 1; Affiliations: 1: National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; Issue Info: 1998, Vol. 42 Issue 2, p136; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2008-07505-001
AN  - 2008-07505-001
AU  - Dawson, Deborah A.
T1  - Proceedings: International Workshop on Consumption Measures and Models for use in Policy Development and Evaluation.
JF  - Alcoholism: Clinical and Experimental Research
JO  - Alcoholism: Clinical and Experimental Research
JA  - Alcohol Clin Exp Res
Y1  - 1998/04//
VL  - 22
IS  - Suppl 2
SP  - 1S
EP  - 3S
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0145-6008
SN  - 1530-0277
AD  - Dawson, Deborah A., National Institute on Alcohol Abuse and Alcoholism/DBE, Willco Building, Suite 514, 6000 Executive Boulevard, MSC 7003, Bethesda, MD, US, 20892-7003
N1  - Accession Number: 2008-07505-001. Partial author list: First Author & Affiliation: Dawson, Deborah A.; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20090420. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: International Workshop on Consumption Measures and Models for Use in Policy Development and Evaluation, May, 1997, Bethesda, MD, US. Major Descriptor: Alcohol Drinking Patterns; Evaluation. Minor Descriptor: Policy Making. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10). Location: US. Page Count: 3. Issue Publication Date: Apr, 1998. 
AB  - The International Workshop on Consumption Measures and Models for Use in Policy Development and Evaluation was held in Bethesda, MD, on May 12-14,1997. Participants included the following: Salme Ahlström, Finland; Timo Alanko, Finland; Loran Archer, USA; Susan Bondy, Canada; Fe Caces, USA; Raul Caetano, USA; Deborah Dawson, USA; Kaye Fillmore, USA; Kathryn Graham, Canada; Thomas Greenfield, USA; Paul Gruenewald, USA; Thomas Harford, USA; Deborah Hasin, USA; Michael Hilton, USA; Harold Holder, USA; Bryan Johnstone, USA; Ronald Knibbe, Netherlands; Eckhart Kühlhorn, Sweden; Paul Lemmens, Netherlands; Klaus Mäkelä, Finland; Maria Elena Medina-Mora, Mexico; Lorraine Midanik, USA; M. W. Bud Perrine, USA; Jürgen Rehm, Canada; Anders Romelsjö, Sweden; Robin Room, Canada; Marcia Russell, USA; John Searles, USA; Eric Single, Canada; Linda Sobell, USA; Tim Stockwell, Australia; Gerald Williams, USA; Richard Wilsnack, USA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - international workshop
KW  - alcohol consumption measures
KW  - consumption models
KW  - policy development
KW  - policy evaluation
KW  - 1998
KW  - Alcohol Drinking Patterns
KW  - Evaluation
KW  - Policy Making
KW  - 1998
DO  - 10.1111/j.1530-0277.1998.tb04367.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-07215-003
AN  - 2005-07215-003
AU  - Kitamura, Toshinori
AU  - Kijima, N.
AU  - Aihara, W.
AU  - Tomoda, A.
AU  - Fukuda, R.
AU  - Yamamoto, M.
T1  - Depression and early experiences among young Japanese women: Multiple facets of experiences and subcategories of depression.
JF  - Archives of Women's Mental Health
JO  - Archives of Women's Mental Health
JA  - Arch Womens Ment Health
Y1  - 1998/04//
VL  - 1
IS  - 1
SP  - 27
EP  - 37
CY  - Germany
PB  - Springer
SN  - 1434-1816
SN  - 1435-1102
AD  - Kitamura, Toshinori, Department of Sociocultural Environmental Research, National Institute of Mental Health, National Centre of Neurology and Psychiatry, 1-7-3, Konodai, Ichikawa, Chiba, Japan, 272-8790
N1  - Accession Number: 2005-07215-003. Partial author list: First Author & Affiliation: Kitamura, Toshinori; Department of Sociocultural Environmental Research, National Institute of Mental Health, Chiba, Japan. Release Date: 20050718. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Early Experience; Human Females; Major Depression. Classification: Affective Disorders (3211). Population: Human (10); Female (40). Location: Japan. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Social Desirability Scale; Parental Bonding Instrument DOI: 10.1037/t06510-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Apr, 1998. 
AB  - The link between childhood experiences (before age of 16) and later onset of depression was examined among 98 young Japanese women who had all been newly employed by a company in Tokyo, Japan. We compared three groups: (a) 15 women who had reported a single episode of DSM-III-R Major Depression of less than two years duration (single episode; S.E.); (b) four women who had reported either more than one episode or any episode of two years or more duration meeting the criteria of Major Depression (recurrent or chronic; R.C.) and; (c) 53 women who had never experienced any major DSM-III-R Axis I disorders (normal control). The three groups did not differ significantly in terms of any parental loss experiences (either death or separation for 12 months or longer). The S.E. group perceived the father to be less affectionate than the other two groups. The R.C. group reported having been punched with a fist by the mother more frequently, and bullied at school. Among early life events (other than being bullied), parental divorce and own illness were reported more frequently by the R.C. group, and not being appointed as a 'class leader' by the S.E. group. These findings suggest that early human experiences are linked to later depression and that single episode and recurrent/chronic depressions are discrete in their life history profiles. In order to screen women who need prevention and intervention (R.C. in particular) in community or school settings, it may be useful to tap their life history. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - depression
KW  - young Japanese women
KW  - childhood experiences
KW  - 1998
KW  - Early Experience
KW  - Human Females
KW  - Major Depression
KW  - 1998
DO  - 10.1007/s007370050003
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2014-20368-016
AN  - 2014-20368-016
AU  - Kim, Yoshiharu
AU  - Kokai, Masahiro
T1  - Earthquake and psychiatry in Kobe.
JF  - The Psychiatric Bulletin
JO  - The Psychiatric Bulletin
JA  - Psychiatr Bull (2014)
Y1  - 1998/04//
VL  - 22
IS  - 4
SP  - 245
EP  - 248
CY  - United Kingdom
PB  - Royal College of Psychiatrists
SN  - 2053-4868
SN  - 2053-4876
AD  - Kim, Yoshiharu, Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan
N1  - Accession Number: 2014-20368-016. Other Journal Title: Psychiatric Bulletin; The Psychiatrist. Partial author list: First Author & Affiliation: Kim, Yoshiharu; Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan. Release Date: 20160725. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Natural Disasters; Psychiatry. Minor Descriptor: Morbidity. Classification: Community & Social Services (3373). Population: Human (10). Location: Japan. References Available: Y. Page Count: 4. Issue Publication Date: Apr, 1998. 
AB  - This article briefs the psychiatric morbidity among Japanese after the earthquake in Kobe. A fire occurred immediately after the earth quake which was just as fatal. This was a complete replication of what had happened in the Kanto earthquake in 1923, the largest in Japanese history. Just after the quake, medical schools and hospitals from all over Japan sent teams to Kobe. Anxiety, depressive moods, and sleep disturbance were also common during the first few months after the shock. On the other hand, the cases of depression were much more concerned with actual loss of jobs or enormous expenses for residual reconstruction. The current problem is how to restore the community, especially in the temporary dwelling in the relocation sites which will be permanent homes for actually those who cannot afford new houses after the earthquake. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - earth quake
KW  - relocation sites
KW  - depressive moods
KW  - psychiatric morbidity
KW  - 1998
KW  - Community Services
KW  - Natural Disasters
KW  - Psychiatry
KW  - Morbidity
KW  - 1998
DO  - 10.1192/pb.22.4.245
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17582-017
AN  - 2004-17582-017
AU  - Lamb, Michael E.
T1  - Revisiting fathers who actively parent.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1998/04//
VL  - 43
IS  - 4
SP  - 271
EP  - 272
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17582-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Father Child Relations; Fathers; Parental Investment; Parental Role. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Geiger, Brenda. Fathers as Primary Caregivers=Westport, CT: Greenwood Press Greenwood, 143 pp; 1996. Page Count: 2. Issue Publication Date: Apr, 1998. 
AB  - The reviewer states that this book (see record [rid]1996-97804-000[/rid]) book offers little new information either to parents wrestling with personal decisions or to scholars and researchers eager to understand changing parental roles and responsibilities. The reviewer states, in summary, that this is a disappointing book. Many important questions about fatherhood, father-child relationships, and the effects of novel parental roles and responsibilities remain unanswered despite the intense recent attention, but none of these questions are either addressed or even framed in interesting or innovative ways. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - parental roles
KW  - father-child relationships
KW  - personal decisions
KW  - parent involvement
KW  - 1998
KW  - Father Child Relations
KW  - Fathers
KW  - Parental Investment
KW  - Parental Role
KW  - 1998
U2  - Geiger, Brenda. (1996); Fathers as Primary Caregivers; Westport, CT: Greenwood Press Greenwood, 143 pp; 0-313-29919-6.
DO  - 10.1037/001601
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2012-20068-028
AN  - 2012-20068-028
AU  - Widenfalk, Johan
AU  - Tomac, Andreas
AU  - Lindqvist, Eva
AU  - Hoffer, Barry
AU  - Olson, Lars
T1  - GFRα‐3, a protein related to GFRα‐1, is expressed in developing peripheral neurons and ensheathing cells.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/04//
VL  - 10
IS  - 4
SP  - 1508
EP  - 1517
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-816X
SN  - 1460-9568
AD  - Widenfalk, Johan, Department of Neuroscience, Karolinska Institute, S-171 77, Stockholm, Sweden
N1  - Accession Number: 2012-20068-028. PMID: 9749804 Partial author list: First Author & Affiliation: Widenfalk, Johan; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Nervous System; Proteins; Neurotrophic Factor; Schwann Cells. Minor Descriptor: Mice; Neuroglia. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 1998. Publication History: Accepted Date: Jan 26, 1998; Revised Date: Jan 21, 1998; First Submitted Date: Jan 5, 1998. Copyright Statement: European Neuroscience Association. 1998. 
AB  - We report here the identification of a gene, termed GFRα-3 (glial cell line-derived neurotrophic factor family receptor alpha-3), related to GFRα-1 and GFRα-2 (also known as GDNFR-α and GDNFR-β), and describe distribution of GDNFα-3 in the nervous system and other parts of the mouse body during development and in the adult. GFRα-3 in situ hybridization signals were found mainly in the peripheral nervous system, with prominent signals in developing dorsal root and trigeminal ganglia. Sympathetic ganglia were also positive. Developing nerves manifested strong GFRα-3 mRNA signals, presumably generated by the Schwann cells. Olfactory ensheathing cells were also positive. Other non-neuronal cells appearing positive during development included chromaffin cells in the adrenal gland and small clusters of cells in the intestinal epithelium. In the central nervous system no robust signals could be detected at any stage investigated with the present probes. Compared with the previously described GFRα-1 and GFRα-2 mRNAs, which are widely distributed in the central nervous system and peripheral organs, the expression of GFRα-3 mRNA is much more restricted. The prominent expression in Schwann cells during development suggests a key role for GFRα-3 in the development of the peripheral nervous system. As Schwann cells are known to lack expression of the transducing RET receptor, we propose that a possible function of GFRα-3 during development could be to bind Schwann cell-derived GDNF-like ligands, thus presenting such molecules to growing axons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - proteins
KW  - peripheral neurons
KW  - ensheathing cells
KW  - nervous system
KW  - neurotrophic factor
KW  - schwann cells
KW  - mice
KW  - neuroglia
KW  - 1998
KW  - Nervous System
KW  - Proteins
KW  - Neurotrophic Factor
KW  - Schwann Cells
KW  - Mice
KW  - Neuroglia
KW  - 1998
U1  - Sponsor: Swedish Medical Research Council, Sweden. Grant: 14X-03185. Recipients: No recipient indicated
U1  - Sponsor: AMF. Recipients: No recipient indicated
U1  - Sponsor: AFA. Recipients: No recipient indicated
U1  - Sponsor: Petrus och Augusta Hedlunds stiftelse. Recipients: No recipient indicated
U1  - Sponsor: US Public Health Service, US. Recipients: No recipient indicated
DO  - 10.1046/j.1460-9568.1998.00192.x
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UR  - Johan.Widenfalk@neuro.ki.se
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40502-023
AN  - 2015-40502-023
AU  - Murphy, Diane D.
AU  - Cole, Nelson B.
AU  - Greenberger, V.
AU  - Segal, Menahem
T1  - Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/04//
VL  - 18
IS  - 7
SP  - 2550
EP  - 2559
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Murphy, Diane D., Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 36, Room 2A25, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-40502-023. Partial author list: First Author & Affiliation: Murphy, Diane D.; Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Segal, Menahem. Major Descriptor: Dendrites; Estradiol; Hippocampus; Neurotransmission; Interneurons. Minor Descriptor: Rats; Pyramidal Neurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 1998. Publication History: Accepted Date: Jan 13, 1998; Revised Date: Jan 13, 1998; First Submitted Date: Sep 18, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - We have previously shown that estradiol causes a twofold rise in dendritic spine density in cultured rat hippocampal neurons, as it does in vivo. More recently, estrogen receptors have been localized to aspiny inhibitory hippocampal interneurons, indicating that their effect on spiny pyramidal neurons may be indirect. We therefore examined the possibility that estradiol affects spine density by regulating inhibition in cultured hippocampal interneurons. Immunocytochemically, estrogen receptors were found to be co-localized with glutamate decarboxylase (GAD)-positive neurons (∼21% of total neurons in the culture). Exposure of cultures to estradiol for 1 d caused a marked decrease (up to 80%) in the GAD content of the interneurons, measured both by immunohistochemistry and Western blotting. Also, the number of GAD-positive neurons in the cultures decreased to 12% of the total cell population. Moreover, GABAergic miniature IPSCs were reduced in both size and frequency by estradiol, whereas miniature EPSCs increased in frequency. We then mimicked the proposed effects of estradiol by blocking GABA synthesis with mercaptopropionic acid (MA). Cultures treated with MA expressed a dose-dependent decrease in GABA immunostaining that mimicked that seen with estradiol. MA-treated cultures displayed a significant 50% increase in dendritic spine density over controls, similar to that produced by estradiol. These results indicate that estradiol decreases GABAergic inhibition in the hippocampus, which appears to effectively increase the excitatory drive on pyramidal cells, and thus may provide a mechanism for formation of new dendritic spines. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hippocampus
KW  - dendritic spines
KW  - interneuron
KW  - estrogen receptors
KW  - GABA
KW  - cultures
KW  - 1998
KW  - Dendrites
KW  - Estradiol
KW  - Hippocampus
KW  - Neurotransmission
KW  - Interneurons
KW  - Rats
KW  - Pyramidal Neurons
KW  - 1998
U1  - Sponsor: National Institutes of Health, Fogarty International Center, US. Other Details: Advanced Study in the Health Sciences. Recipients: Segal, Menahem
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40502-023&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40502-024
AN  - 2015-40502-024
AU  - Fueshko, Susan M.
AU  - Key, Sharon
AU  - Wray, Susan
T1  - GABA inhibits migration of luteinizing hormone-releasing hormone neurons in embryonic olfactory explants.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/04//
VL  - 18
IS  - 7
SP  - 2560
EP  - 2569
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wray, Susan, Laboratory of Neurochemistry, National Institutes of Health, Building 36, Room 4D-12, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-40502-024. PMID: 9502815 Partial author list: First Author & Affiliation: Fueshko, Susan M.; Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160303. Correction Date: 20160307. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Luteinizing Hormone; N-Methyl-D-Aspartate; Neurons; Olfactory Nerve; Migration of Nerve Cells. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 1998. Publication History: Accepted Date: Jan 19, 1998; Revised Date: Jan 14, 1998; First Submitted Date: Aug 28, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - During development, a subpopulation of olfactory neurons transiently expresses GABA. The spatiotemporal pattern of GABAergic expression coincides with migration of luteinizing hormone-releasing hormone (LHRH) neurons from the olfactory pit to the CNS. In this investigation, we evaluated the role of GABAergic input on LHRH neuronal migration using olfactory explants, previously shown to exhibit outgrowth of olfactory axons, migration of LHRH neurons in association with a subset of these axons, and the presence of the olfactory-derived GABAergic neuronal population. GABAA receptor antagonists bicuculline (10-5 M) or picrotoxin (10-4 M) had no effect on the length of peripherin-immunoreactive olfactory fibers or LHRH cell number. However, LHRH cell migration, as determined by the distance immunopositive cells migrated from olfactory pits, was significantly increased by these perturbations. Addition of tetrodotoxin (10-6 M), to inhibit Na+-transduced electrical activity, also significantly enhanced LHRH migration. The most robust effect observed was dramatic inhibition of LHRH cell migration in explants cultured in the presence of the GABAA receptor agonist muscimol (10-4 M). This study demonstrates that GABAergic activity in nasal regions can have profound effects on migration of LHRH neurons and suggests that GABA participates in appropriate timing of LHRH neuronal migration into the developing brain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GABA
KW  - GnRH
KW  - olfactory
KW  - peripherin
KW  - tetrodotoxin
KW  - immunocytochemistry
KW  - 1998
KW  - Luteinizing Hormone
KW  - N-Methyl-D-Aspartate
KW  - Neurons
KW  - Olfactory Nerve
KW  - Migration of Nerve Cells
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40502-024&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107266809
T1  - Issues in comparisons between meta-analyses and large trials.
AU  - Ioannidis JPA
AU  - Cappelleri JC
AU  - Lau J
AU  - Ioannidis, J P
AU  - Cappelleri, J C
AU  - Lau, J
Y1  - 1998/04/08/
N1  - Accession Number: 107266809. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: LeLorier J, Gregoire G. Comparing results from meta-analyses vs large trials. (JAMA) 8/12/98; 280 (6): 518-519. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Clinical Trials
KW  - Meta Analysis
KW  - Research Measurement
KW  - Research Protocols
KW  - Correlation Coefficient
KW  - Comparative Studies
KW  - Statistical Significance
KW  - Treatment Outcomes
KW  - Validity
KW  - Kappa Statistic
KW  - Data Analysis, Statistical
KW  - Human
SP  - 1089
EP  - 1093
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 279
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: The extent of concordance between meta-analyses and large trials on the same topic has been investigated with different protocols. Inconsistent conclusions created confusion regarding the validity of these major tools of clinical evidence.Objective: To evaluate protocols comparing meta-analyses and large trials in order to understand if and why they disagree on the concordance of these 2 clinical research methods.Design: Systematic comparison of protocol designs, study selection, definitions of agreement, analysis methods, and reported discrepancies between large trials and meta-analyses.Results: More discrepancies were claimed when large trials were selected from influential journals (which may prefer trials disagreeing with prior evidence) than from already performed meta-analyses (which may target homogeneous trials) and when both primary and secondary (rather than only primary) end points were considered. Depending on how agreement was defined, kappa coefficients varied from 0.22 (low agreement) to 0.72 (excellent agreement). The correlation of treatment effects between large trials and meta-analyses varied from -0.12 to 0.76, but was more similar (0.50-0.76) when only primary end points were considered. When both the magnitude and uncertainty of treatment effects were considered, large trials disagreed with meta-analyses 10% to 23% of the time. Discrepancies were attributed to different disease risks, variable protocols, quality, and publication bias.Conclusions: Comparisons of large trials with meta-analyses may reach different conclusions depending on how trials and meta-analyses are selected and how end points and agreement are defined. Scrutiny of these 2 major research methods can enhance our appreciation of both for guiding medical practice.
SN  - 0098-7484
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
AD  - Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Bldg, Room 2C31, 6003 Executive Blvd, Bethesda, MD 20852 (e-mail: ji24m@nih.gov)
U2  - PMID: 9546568.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107089761
T1  - Cardiovascular events and mortality in newly and chronically depressed persons > 70 years of age.
AU  - Penninx BWJ
AU  - Guralnik JM
AU  - de Leon CFM
AU  - Pahor M
AU  - Visser M
AU  - Corti M
AU  - Wallace RB
Y1  - 1998/04/15/
N1  - Accession Number: 107089761. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: Contracts NO1-AG-0215, NO1-AG-02106, and NO1-AG-02107 from the National Institute on Aging and the Dutch Niels Stensen Stichting. NLM UID: 0207277. 
KW  - Cardiovascular Diseases -- Epidemiology
KW  - Depression -- Complications
KW  - Age Factors
KW  - Cardiovascular Diseases -- Complications
KW  - Cause of Death
KW  - Chronic Disease
KW  - Depression -- Mortality
KW  - Incidence
KW  - Predictive Value of Tests
KW  - Cardiovascular Risk Factors
KW  - Psychological Tests
KW  - Time Factors
KW  - Center for Epidemiological Studies Depression Scale
KW  - Survival
KW  - Prospective Studies
KW  - Questionnaires
KW  - Epidemiological Research
KW  - Kaplan-Meier Estimator
KW  - Cox Proportional Hazards Model
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 988
EP  - 994
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
JA  - AM J CARDIOL
VL  - 81
IS  - 8
CY  - Philadelphia, Pennsylvania
PB  - Elsevier Inc.
SN  - 0002-9149
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Gateway Bldg., Suite 3C-309, Bethesda, MD 20892-9205
U2  - PMID: 9576158.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Takai, S.
AU  - Lorenzi, M.V.
AU  - Long, J.E.
AU  - Yamada, K.
AU  - Miki, T.
T1  - Assignment<FOOTREF>[sup 1] </FOOTREF> of the Ect2 protooncogene to mouse chromosome band 3B by in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/04/15/
VL  - 81
IS  - 1
M3  - Article
SP  - 83
EP  - 84
SN  - 03010171
AB  - Abstract. The mouse Ect2 (&eumacr;pithelial &cumacr;ell &tumacr;ransforming gene &2umacr;) was isolated from Balb/MK mouse epithelial cells using an expression cloning approach (Miki et al., 1993). In this approach a Balb/MK cDNA expression library was introduced into NIH/3T3 fibroblasts to induce foci of morphologically transformed cells, from which the Ect2 cDNA was rescued. Ect2 is activated by amino-terminal truncation of the protooncogene product and truncated cDNA clones can efficiently induce tiny but well piled-up foci containing both fusiform and rounded cells. The Ect2 transfectants can induce tumors efficiently upon injection of nude mice. The catalytic domain of Ect2 protein exhibits a structural similarity with regulator molecules of the Rho family of small GTP-binding proteins, including the breakpoint cluster gene product, Bcr, the yeast cell cycle regulator, Cdc24, and the Dbl oncoprotein. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cytogenetics & Cell Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE mapping
KW  - ONCOGENES
KW  - CHROMOSOMES
KW  - EPITHELIAL cells
KW  - IN situ hybridization
KW  - CHROMOSOME banding
KW  - CLONING
N1  - Accession Number: 12184174; Takai, S. 1 Lorenzi, M.V. 2 Long, J.E. 2 Yamada, K. 1 Miki, T. 2; Affiliation:  1: Department of Genetics, Research Institute, International Medical Center of Japan, Tokyo (Japan).  2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD (USA).; Source Info: Apr98, Vol. 81 Issue 1, p83; Subject Term: GENE mapping; Subject Term: ONCOGENES; Subject Term: CHROMOSOMES; Subject Term: EPITHELIAL cells; Subject Term: IN situ hybridization; Subject Term: CHROMOSOME banding; Subject Term: CLONING; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000014994
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nead, Michael A.
AU  - Baglia, Laurel A.
AU  - Antinore, Michael J.
AU  - Ludlow, John W.
AU  - McCance, Dennis J.
T1  - Rb binds c-Jun and activates transcription.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/04/15/
VL  - 17
IS  - 8
M3  - Article
SP  - 2342
EP  - 2352
SN  - 02614189
AB  - The retinoblastoma protein (Rb) acts as a critical cell-cycle regulator and loss of Rb function is associated with a variety of human cancer types. Here we report that Rb binds to members of the AP-1 family of transcription factors, including c-Jun, and stimulates c-Jun transcriptional activity from an AP-1 consensus sequence. The interaction involves the leucine zipper region of c-Jun and the B pocket of Rb as well as a C-terminal domain. We also present evidence that the complexes are found in terminally differentiating keratinocytes and cells entering the G1 phase of the cell cycle after release from serum starvation. The human papillomavirus type 16 E7 protein, which binds to both c-Jun and Rb, inhibits the ability of Rb to activate c-Jun. The results provide evidence of a role for Rb as a transcriptional activator in early G1 and as a potential modulator of c-Jun expression during keratinocyte differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RETINOBLASTOMA
KW  - PROTEINS
KW  - LEUCINE zippers
KW  - DNA-binding proteins
KW  - TRANSCRIPTION factors
KW  - GENETIC transcription
KW  - BINDING sites (Biochemistry)
KW  - PAPILLOMAVIRUSES
KW  - ap-1 factors
KW  - retinoblastoma protein
KW  - transactivation
N1  - Accession Number: 13006164; Nead, Michael A. 1 Baglia, Laurel A. 1 Antinore, Michael J. 1,2 Ludlow, John W. 3,4 McCance, Dennis J. 1,4; Email Address: djmc@uhura.cc.rochester.edu; Affiliation:  1: Department of Microbioloy and Immunology, University of Rochester, Rochester, NY, USA  2: Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA  3: Department of Biochemistry, University of Rochester, Rochester, NY, USA  4: Cancer Center, University of Rochester, Rochester, NY, USA; Source Info: 4/15/98, Vol. 17 Issue 8, p2342; Subject Term: RETINOBLASTOMA; Subject Term: PROTEINS; Subject Term: LEUCINE zippers; Subject Term: DNA-binding proteins; Subject Term: TRANSCRIPTION factors; Subject Term: GENETIC transcription; Subject Term: BINDING sites (Biochemistry); Subject Term: PAPILLOMAVIRUSES; Author-Supplied Keyword: ap-1 factors; Author-Supplied Keyword: retinoblastoma protein; Author-Supplied Keyword: transactivation; Number of Pages: 11p; Document Type: Article
L3  - 10.1093/emboj/17.8.2342
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kaler, Stephen G.
T1  - Diagnosis and therapy of Menkes syndrome, a genetic form of copper deficiency.
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
Y1  - 1998/05//
VL  - 67
IS  - 5
M3  - Article
SP  - 1029S
EP  - 1034S
SN  - 00029165
AB  - In the 25 y since copper deficiency was first delineated in persons with Menkes syndrome, advances in our understanding of the clinical, biochemical, and molecular aspects of this rare disorder have surpassed progress in the design of effective therapies. In contrast with purely nutritional copper deficiency, in which copper replacement can be curative, the nature of the basic defect in Menkes syndrome suggests that corrective efforts are likely to be more complicated, a point supported by the cumulative literature on this topic as well as by emerging molecular data. In this paper, certain clinical, biochemical, and molecular aspects of copper histidine treatment in 25 Menkes syndrome patients at the National Institutes of Health are reviewed. The delineation of a distinctive neurochemical pattern in plasma and cerebrospinal fluid, reflecting deficiency of the copper enzyme dopamine β-monooxygenase, is arguably the most important finding in the study of Menkes syndrome. This abnormal pattern has proven extremely reliable as a rapid diagnostic test, enabling early identification of affected infants—a fundamental requirement for improving clinical outcomes. Of 11 patients identified by prenatal or prompt postnatal testing and treated within the first 10 d of age, one walked at 14 mo of age and has normal neurodevelopment at age 3 y and another infant’s early progress appears promising. However, five patients died in infancy and neurodevelopmental outcome was suboptimal in four others. Consideration of additional therapeutic strategies seems necessary, therefore, for most patients and families facing this troublesome form of copper deficiency. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - catecholamines
KW  - copper
KW  - dopamine β-monooxygenase
KW  - infants
KW  - Menkes syndrome
KW  - mutations
KW  - splicing
N1  - Accession Number: 97459455; Kaler, Stephen G. 1; Email Address: sgk@box-s.nih.gov; Affiliations: 1: Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 4D20, 10 Center Drive MSC 1424, Bethesda, MD 20892-1424.; Issue Info: May98, Vol. 67 Issue 5, p1029S; Author-Supplied Keyword: catecholamines; Author-Supplied Keyword: copper; Author-Supplied Keyword: dopamine β-monooxygenase; Author-Supplied Keyword: infants; Author-Supplied Keyword: Menkes syndrome; Author-Supplied Keyword: mutations; Author-Supplied Keyword: splicing; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Reiss, W.G.
AU  - Piscitelli, S.C.
T1  - Drug-Cytokine Interactions: Mechanisms and Clinical Implications.
JO  - BioDrugs
JF  - BioDrugs
Y1  - 1998/05//
VL  - 9
IS  - 5
M3  - Article
SP  - 389
EP  - 395
PB  - Springer Science & Business Media B.V.
SN  - 11738804
AB  - The potential for certain cytokines to alter cytochrome P450-mediated drug metabolism was first described over 20 years ago. Since that time, a number of in vitro studies in a variety of models have confirmed those observations and evaluated the possible mechanisms. Although the actual mechanism(s) remains unknown, several potential theories have been proposed, including the inhibition of mRNA transcription, increased haem oxygenase activity, increased xanthine oxidase activity and the induction of killer cells cytotoxic to liver cells containing cytochrome P450. Clinical data regarding drug-cytokine interactions are currently limited to the results of studies with small patient numbers and case reports. In addition, the results of different reports are often conflicting. Some clinical studies have reported associations between exogenous or endogenous cytokines and alterations in concomitantly administered drugs, whereas others have reported a lack of effect. Differences in cytokine dosages, route of administration, time course of therapy, sample collection times and patient variability are all likely to account for the varied results. In this rapidly expanding field, additional research will better define the mechanisms of these interactions and their clinical implications. [ABSTRACT FROM AUTHOR]
AB  - Copyright of BioDrugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOKINES
KW  - CYTOCHROME P-450
KW  - Biotechnology
KW  - Drug-interactions
KW  - Immunomodulators, drug-interactions
KW  - Interferon-alpha, drug-interactions
KW  - Interferon-beta, drug-interactions
KW  - Interleukin-6, drug-interactions
KW  - Metabolism
KW  - Research-and-development
KW  - Reviews-on-treatment
KW  - Transforming-growth-factor-beta-1, drug-interactio
N1  - Accession Number: 9522736; Reiss, W.G. 1 Piscitelli, S.C. 2; Affiliation:  1: Department of Pharmacy Practice and Science, Pharmacokinetics-Biopharmaceutics Laboratory,School of Pharmacy, University of Maryland, Baltimore, Maryland, USA  2: Clinical Pharmacokinetics Research Laboratory, Department of Pharmacy, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 1998, Vol. 9 Issue 5, p389; Subject Term: CYTOKINES; Subject Term: CYTOCHROME P-450; Author-Supplied Keyword: Biotechnology; Author-Supplied Keyword: Drug-interactions; Author-Supplied Keyword: Immunomodulators, drug-interactions; Author-Supplied Keyword: Interferon-alpha, drug-interactions; Author-Supplied Keyword: Interferon-beta, drug-interactions; Author-Supplied Keyword: Interleukin-6, drug-interactions; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Research-and-development; Author-Supplied Keyword: Reviews-on-treatment; Author-Supplied Keyword: Transforming-growth-factor-beta-1, drug-interactio; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107263869
T1  - Oprah and the mad cow disease question.
AU  - Brown P
Y1  - 1998/05//
N1  - Accession Number: 107263869. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 9891730. 
KW  - Encephalopathy, Bovine Spongiform
KW  - Meat
KW  - Consumer Product Safety
SP  - 7
EP  - 8
JO  - Bottom Line Health
JF  - Bottom Line Health
JA  - BOTTOM LINE HEALTH
VL  - 12
IS  - 5
CY  - Greenwich, Connecticut
PB  - Health Confidential
SN  - 1092-0129
AD  - Senior Research Scientist, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rasmusson, Xeno D.
AU  - Zonderman, Alan B.
AU  - Kawas, Claudia
AU  - Resnick, Susan M.
T1  - Effects of Age and Dementia on the Trail Making Test.
JO  - Clinical Neuropsychologist
JF  - Clinical Neuropsychologist
Y1  - 1998/05//
VL  - 12
IS  - 2
M3  - Article
SP  - 169
EP  - 178
SN  - 13854046
AB  - Trail Making Test (TMT) performance was investigated in 765 elderly volunteers (age range 60 to 96 years), 58 of whom met DSM-III-R criteria for dementia and 40 dementia ``suspects,'' who showed mild changes in one or two cognitive domains. Cross-sectional analyses of the 667 nondemented participants, revealed significant age effects in completion times for both Parts A and B. Prevalence of errors increased with age on Part B, but not on Part A. Two-year longitudinal changes were examined in a subset of the nondemented sample (n = 385). Significant slowing was found for Part B, but not for Part A, with older age groups showing the greatest change. Error rates did not increase. Dementia status accounted for a significant proportion of the variance in completion times after accounting for age, education, and gender. Receiver operating characteristic analyses suggest that the TMT may be useful in screening for cognitive dysfunction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Neuropsychologist is the property of Psychology Press (UK) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HALSTEAD-Reitan Neuropsychological Test Battery
KW  - DEMENTIA
KW  - OLDER people
N1  - Accession Number: 5259484; Rasmusson, Xeno D. 1 Zonderman, Alan B. 1 Kawas, Claudia 2 Resnick, Susan M. 1; Affiliation:  1: National Institute on Aging, Laboratory of Personality and Cognition, USA, Baltimore, MD 21224-6823, 5600 Nathan Shock Drive  2: Johns Hopkins University School of Medicine, Department of Neurology, USA, Baltimore; Source Info: May98, Vol. 12 Issue 2, p169; Subject Term: HALSTEAD-Reitan Neuropsychological Test Battery; Subject Term: DEMENTIA; Subject Term: OLDER people; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Latour, Sylvain
AU  - Zhang, Juan
AU  - Siraganian, Reuben P.
AU  - Veillette, André
T1  - A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/05//5/1/98
VL  - 17
IS  - 9
M3  - Article
SP  - 2584
EP  - 2595
SN  - 02614189
AB  - Accumulating data indicate that the ‘linker’ region of Syk, which lies between its tandem Src homology 2 (SH2) domains and kinase region, provides a critical function for the biological activity of Syk. This importance has been ascribed to the presence of tyrosine phosphorylation sites capable of mediating the recruitment of cellular effectors. We and others previously identified an alternatively spliced variant of Syk, termed SykB, which lacks a 23 amino acid sequence in the linker domain. As this ‘linker insert’ is also not present in the closely related enzyme Zap-70, it seems plausible that Syk possesses this unique sequence for functional reasons. To understand its role better, we have compared the abilities of Syk and SykB to participate in immunoreceptor-triggered signal transduction. The results of our experiments revealed that, unlike Syk, SykB was inefficient at coupling stimulation of FceRI on basophils or the antigen receptor on T cells to the early and late events of cellular activation. Further studies showed that the functional defect in SykB was not caused by the absence of crucial tyrosine phosphorylation sites, or by a reduced intrinsic kinase activity. Rather, it correlated with the reduced ability of SykB to bind phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) in vitro and in vivo. In combination, these results demonstrated that the unique insert in the linker domain of Syk is crucial for its capacity to participate in immunoreceptor signalling. Furthermore, they provided evidence that the linker region can regulate the ability of Syk to bind ITAMs, thus identifying a novel function for this domain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHORYLATION
KW  - TYROSINE
KW  - AMINO acids
KW  - ENZYMES
KW  - hemopoietic cells
KW  - linker
KW  - syk
KW  - tyrosine protein kinase
N1  - Accession Number: 13006197; Latour, Sylvain 1 Zhang, Juan 2,3,4,5 Siraganian, Reuben P. 6 Veillette, André 6; Email Address: veillette@medcor.mcgill.ca; Affiliation:  1: McGill Cancer Centre, McGill University, Montréal, Québec, Canada  2: Department of Biochemistry, McGill University, Montréal, Qu&ecute;bec, Canada  3: Department of Medicine, McGill University, Montréal, Québec, Canada  4: Department of Oncology, McGill University, Montréal, Québec, Canada  5: Departments of Medicine and Oncology, Montreal General Hospital, Montréal, Québec, Canada  6: Receptors and Signal Transdcution Section, OIIB, NIDR, National Institutes of Health, Bethesda, MD, USA; Source Info: 5/1/98, Vol. 17 Issue 9, p2584; Subject Term: PHOSPHORYLATION; Subject Term: TYROSINE; Subject Term: AMINO acids; Subject Term: ENZYMES; Author-Supplied Keyword: hemopoietic cells; Author-Supplied Keyword: linker; Author-Supplied Keyword: syk; Author-Supplied Keyword: tyrosine protein kinase; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/17.9.2584
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13006197&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Klutch, Michael
AU  - Woerner, Amy M.
AU  - Marcus-Sekura, Carol J.
AU  - Levin, Judith G.
T1  - Generation of HIV-1/HIV-2 Cross-Reactive Peptide Antisera by Small Sequence Changes in HIV-1 Reverse Transcriptase and Integrase Immunizing Peptides.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1998/05//
VL  - 5
IS  - 3
M3  - Article
SP  - 192
EP  - 202
PB  - BioMed Central
SN  - 10217770
AB  - We have generated peptide antisera against selected regions in HIV-1 and HIV-2 reverse transcriptase (RT) and integrase (IN) to investigate the specificity of determinants governing the immune response. Peptides representing homologous regions (>50%) in the N- and C-termini and central portions of these proteins were synthesized and injected into rabbits. HIV-1 and HIV-2 IN peptide antisera inhibited IN-mediated cleavage of an HIV-1 DNA oligonucleotide substrate in a 3′ processing assay, while anti-RT or normal sera had no effect. None of the RT sera inhibited RT activity. In Western blots, HIV-2 antisera directed against RT or IN peptides recognized HIV-2 RT and IN proteins, respectively, as expected, but also cross-reacted with the corresponding HIV-1 proteins. By contrast, corresponding HIV-1 antisera were type-specific. In some cases, HIV-1 cross-reactive antisera could be generated by immunization with HIV-1 chimeric peptides with as few as two residues in the HIV-1 sequence changed to the corresponding HIV-2 amino acids. The finding that a type-specific response can be converted to a cross-reactive response suggests alternate strategies for developing new diagnostic reagents which detect HIV-1 and HIV-2. In addition, our results provide a general model for generating HIV peptide vaccines with dual specificity against HIV-1 and HIV-2. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV (Viruses)
KW  - PEPTIDES
KW  - IMMUNE serums
KW  - IMMUNE response
KW  - ENZYMES
KW  - Chimeric peptides
KW  - Cross-reactive response
KW  - Enzyme assays
KW  - HIV-1
KW  - HIV-2
KW  - Integrase
KW  - Peptide antisera
KW  - Peptide diagnostics
KW  - Reverse transcriptase
KW  - Synthetic peptides
N1  - Accession Number: 11372031; Klutch, Michael 1 Woerner, Amy M. 1 Marcus-Sekura, Carol J. 1 Levin, Judith G. 2; Affiliation:  1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration  2: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 5 Issue 3, p192; Subject Term: HIV (Viruses); Subject Term: PEPTIDES; Subject Term: IMMUNE serums; Subject Term: IMMUNE response; Subject Term: ENZYMES; Author-Supplied Keyword: Chimeric peptides; Author-Supplied Keyword: Cross-reactive response; Author-Supplied Keyword: Enzyme assays; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: HIV-2; Author-Supplied Keyword: Integrase; Author-Supplied Keyword: Peptide antisera; Author-Supplied Keyword: Peptide diagnostics; Author-Supplied Keyword: Reverse transcriptase; Author-Supplied Keyword: Synthetic peptides; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
L3  - 10.1159/000025331
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11372031&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ningaraj, Nagendra S.
AU  - Rao, Mamatha K.
T1  - Disulfiram Augments Oxidative Stress in Rat Brain following Bilateral Carotid Artery Occlusion.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1998/05//
VL  - 5
IS  - 3
M3  - Article
SP  - 226
EP  - 230
PB  - BioMed Central
SN  - 10217770
AB  - We examined the brain oxidative stress which accompanies 30 min of bilateral carotid artery ligation (BCAL) in terms of changes in brain levels of glutathione; reduced (GSH) and oxidized (GSSG) forms and the exacerbation of oxidative stress by disulfiram (DSF). These results indicate that BCAL alone decreases GSH content and limits glutathione reductase (GR) activity, and these changes were enhanced by DSF pretreatment. Similar observations were recorded with DSF alone. GR activity (74.3 ± 4.0 µmol min[sup –1] mg[sup –1] tissue; p < 0.001) and GSH content (1.23 ± 0.06 µmol min[sup –1] g[sup –1] tissue; p < 0.001) was attenuated in rats subjected to synergistic effect of BCAL and DSF with a concomitant increase of GSSG (0.006 ± 0.006 µmol min[sup –1] g[sup –1] tissue; p < 0.001). Recovery of GSH/GSSG level and GR activity during reperfusion following 30 min BCAL was considerably delayed (96 h) in the BCAL and DSF group as compared to the recovery time of 24 h in the group subjected to BCAL-reperfusion alone. Perturbation of GSH/GSSG homeostasis as a result of BCAL was augmented by DSF. These findings clearly demonstrate central nervous system oxidative stress due to a BCAL-DSF synergistic effect. Based on the results obtained with this model, we conclude that DSF increases brain oxidative stress and this may be detrimental to alcoholics who might drink and develop an acetaldehyde-induced hypotension while taking DSF. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISULFIRAM
KW  - ENZYME inhibitors
KW  - STRESS (Physiology)
KW  - ISCHEMIA
KW  - BLOOD circulation disorders
KW  - REPERFUSION (Physiology)
KW  - CAROTID artery
KW  - Disulfiram
KW  - GSH
KW  - Ischemia
KW  - Oxidative stress
KW  - Reperfusion
N1  - Accession Number: 11372027; Ningaraj, Nagendra S. 1 Rao, Mamatha K. 1; Affiliation:  1: Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India; Source Info: 1998, Vol. 5 Issue 3, p226; Subject Term: DISULFIRAM; Subject Term: ENZYME inhibitors; Subject Term: STRESS (Physiology); Subject Term: ISCHEMIA; Subject Term: BLOOD circulation disorders; Subject Term: REPERFUSION (Physiology); Subject Term: CAROTID artery; Author-Supplied Keyword: Disulfiram; Author-Supplied Keyword: GSH; Author-Supplied Keyword: Ischemia; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Reperfusion; Number of Pages: 5p; Document Type: Article
L3  - 10.1159/000025335
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11372027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107281851
T1  - Dietary sources of nutrients among US adults, 1989 to 1991.
AU  - Subar AF
AU  - Krebs-Smith SM
AU  - Cook A
AU  - Kahle LL
Y1  - 1998/05//
N1  - Accession Number: 107281851. Language: English. Entry Date: 19980901. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061. 
KW  - Diet
KW  - Nutrients
KW  - Diet Records
KW  - Energy Intake
KW  - Macronutrients
KW  - Vitamins -- Administration and Dosage
KW  - Carotene -- Administration and Dosage
KW  - Minerals -- Administration and Dosage
KW  - United States
KW  - Adult
KW  - Dietary Fiber -- Administration and Dosage
KW  - Cholesterol, Dietary -- Administration and Dosage
KW  - Human
SP  - 537
EP  - 547
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 98
IS  - 5
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - National Cancer Institute, Applied Research Branch, 6130 Executive Blvd, MSC 7344, EPN 313, Bethesda, MD 20892-7344
U2  - PMID: 9597026.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107281851&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 105387610
T1  - A comparison of group and individual performance among subject experts and untrained workers at the document retrieval task.
AU  - Wilbur WJ
Y1  - 1998/05//
N1  - Accession Number: 105387610. Language: English. Entry Date: 20090731. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Computer/Information Science; Peer Reviewed; USA. NLM UID: 0232761. 
KW  - Expert Clinicians
KW  - Information Retrieval
KW  - Knowledge
KW  - Novice Clinicians
KW  - Information Retrieval -- Evaluation
KW  - Molecular Biology
KW  - Random Sample
KW  - Vocabulary, Controlled
KW  - Human
SP  - 517
EP  - 529
JO  - Journal of the American Society for Information Science
JF  - Journal of the American Society for Information Science
JA  - J AM SOC INF SCI
VL  - 49
IS  - 6
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
SN  - 0002-8231
AD  - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; wilbur@ncbi.nlm.nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105387610&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107159203
T1  - Black/White differences in the relationship between MMSE scores and disability: the Women's Health and Aging Study.
AU  - Leveille SG
AU  - Guralnik JM
AU  - Ferrucci L
AU  - Corti MC
AU  - Kasper J
AU  - Fried LP
Y1  - 1998/05//
N1  - Accession Number: 107159203. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 9508483. 
KW  - Geriatric Functional Assessment
KW  - Cognition
KW  - Race Factors
KW  - Women -- In Old Age -- Maryland
KW  - Maryland
KW  - Stratified Random Sample
KW  - Blacks
KW  - Whites
KW  - Instrument Validation
KW  - Activities of Daily Living
KW  - Descriptive Statistics
KW  - Pearson's Correlation Coefficient
KW  - Logistic Regression
KW  - Linear Regression
KW  - Chi Square Test
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Educational Status
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - P201
EP  - 8
JO  - Journals of Gerontology Series B: Psychological Sciences & Social Sciences
JF  - Journals of Gerontology Series B: Psychological Sciences & Social Sciences
JA  - J GERONTOL B PSYCHOL SCI SOC SCI
VL  - 53
IS  - 3
PB  - Oxford University Press / USA
AB  - The purpose of this article is to examine Black/White differences among older women in the relationship between physical functional difficulties and variations in cognitive status, measured within the low to high normal range of the Mini-Mental State Examination (MMSE). We studied 3,585 women with MMSE scores of 18 and above from a population-based random sample of 3,841 community-dwelling women aged 65 and older living in East Baltimore, Maryland. Trained interviewers administered the MMSE and obtained information on demographics, medical conditions, and functional difficulties. Prevalence of any functional difficulty was 43.3% in Whites and 48.5% in Blacks, who were 25% of the study sample. After adjusting for age and education, a significant trend for increasing functional difficulty with decreasing MMSE scores was found in White women but not in Black women. Since no explanation for these racial differences could be identified, these findings suggest that the MMSE may not be a valid predictor of functional difficulty in Black women who score > or = 18 on the instrument.
SN  - 1079-5014
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Suite 3C-309, Bethesda, MD 20892; e-mail: leveills@gw.nia.nih.gov
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Fernández-Llama, Patricia
AU  - Andrews, Peter
AU  - Nielsen, Søren
AU  - Ecelbarger, Carolyn A.
AU  - Knepper, Mark A.
T1  - Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome1.
JO  - Kidney International
JF  - Kidney International
Y1  - 1998/05//
VL  - 53
IS  - 5
M3  - Article
SP  - 1244
EP  - 1253
SN  - 00852538
AB  - Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome. Nephrotic syndrome is associated with abnormal regulation of renal water excretion. To investigate the role of collecting duct water channels and solute transporters in this process, we have carried out semiquantitative immunoblotting of kidney tissues from rats with adriamycin-induced nephrotic syndrome. These experiments demonstrated that adriamycin-induced nephrotic syndrome is associated with marked decreases in expression of aquaporin-2, aquaporin-3, aquaporin-4, and the vasopressin-regulated urea transporter in renal inner medulla, indicative of a suppression of the capacity for water and urea absorption by the inner medullary collecting duct. In contrast, expression of the α1 -subunit of the Na,K-ATPase in the inner medulla was unaltered. Light and electron microscopy of perfusion-fixed kidneys demonstrated that the collecting ducts are morphologically normal and unobstructed. Inner medullary expression of the descending limb water channel, aquaporin-1, was not significantly altered, pointing to a selective effect on the collecting duct. Aquaporin-2 and aquaporin-3 expression was also markedly diminished in the renal cortex, indicating that the effect is not limited to the inner medullary collecting duct. Differential centrifugation studies and immunocytochemistry in inner medullary thin sections demonstrated increased targeting of aquaporin-2 to the plasma membrane, consistent with the expected short-term action of vasopressin on aquaporin-2 trafficking. The extensive down-regulation of aquaporin and urea transporter expression may represent an appropriate renal response to the extracellular volume expansion observed in nephrotic syndrome, but may occur at the expense of decreased urinary concentrating and diluting capacity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DOXORUBICIN
KW  - NEPHROTIC syndrome
KW  - collecting duct
KW  - vasopressin
KW  - water channels
KW  - water permeability
N1  - Accession Number: 5881956; Fernández-Llama, Patricia 1,2 Andrews, Peter 1,2 Nielsen, Søren 1,2 Ecelbarger, Carolyn A. 1,2 Knepper, Mark A. 1,2; Affiliation:  1: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, and Department of Cell Biology, Georgetown University School of Medicine, Washington, D.C., USA,  2: Department of Cell Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Source Info: May1998, Vol. 53 Issue 5, p1244; Subject Term: DOXORUBICIN; Subject Term: NEPHROTIC syndrome; Author-Supplied Keyword: collecting duct; Author-Supplied Keyword: vasopressin; Author-Supplied Keyword: water channels; Author-Supplied Keyword: water permeability; Number of Pages: 10p; Illustrations: 4 Color Photographs, 2 Black and White Photographs, 3 Charts, 7 Graphs; Document Type: Article
L3  - 10.1046/j.1523-1755.1998.00878.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104798073
T1  - Breast cancer susceptibility genes. BRCA1 and BRCA2.
AU  - Brody, L C
AU  - Biesecker, B B
Y1  - 1998/05//1998 May
N1  - Accession Number: 104798073. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Breast Neoplasms
KW  - Genes, BRCA
KW  - Proteins
KW  - Aged
KW  - Aged, 80 and Over
KW  - Alleles
KW  - Breast Neoplasms -- Epidemiology
KW  - Chromosomes
KW  - Genes
KW  - Female
KW  - Genetics
KW  - Genetic Screening
KW  - Middle Age
KW  - Pedigree
KW  - Mutation
KW  - Risk Factors
SP  - 208
EP  - 226
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 77
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Mutations in the BRCA1 and BRCA2 genes lead to an increased susceptibility to breast, ovarian, and other cancers. It is estimated that 3%-8% of all women with breast cancer will be found to carry a mutation in 1 of these genes. Families with multiple affected first-degree relatives and patients with early-onset disease have been found to harbor mutations at a higher frequency. The BRCA1 and BRCA2 genes code for large proteins that bear no resemblance to other known genes. In the cell, they appear to act as tumor suppressor genes and play a role in the maintenance of genome integrity, although the precise function of these genes has yet to be discovered. A large number of distinct mutations have been found in cancer families around the world. The majority of the defined pathologic mutations result in premature truncation of the protein (frameshift and nonsense mutations). These mutations may substantially increase the risk for breast and ovarian cancer, but a precise risk estimate for each different mutation cannot be determined. Depending on the familial context, the risk of breast cancer associated with carrying a mutation has been estimated to range from 50% to 85%. The role of these genes in sporadic cancer remains unknown. Patients and physicians considering BRCA1 and BRCA2 genetic testing are faced with a difficult decision. The diversity of mutations and lack of general population data prevent accurate risk prediction. This is further complicated by the paucity of data on effective prevention strategies for those identified at higher risk. Thus, the nature of clinical testing for BRCA1 and BRCA2 continues to present challenges that reinforce the necessity of personal choice within the context of thorough genetic counseling.
SN  - 0025-7974
AD  - Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-4442, USA. lbrody@helix.nih.gov
U2  - PMID: 9653432.
DO  - 10.1097/00005792-199805000-00006
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107276257
T1  - Guest editorial. Launching your research career through postdoctoral training opportunities.
AU  - Wysocki AB
Y1  - 1998/05//1998 May-Jun
N1  - Accession Number: 107276257. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 0376404. 
KW  - Research, Nursing -- Education
KW  - Education, Post-Doctoral
KW  - Training Support, Financial
SP  - 127
EP  - 128
JO  - Nursing Research
JF  - Nursing Research
JA  - NURS RES
VL  - 47
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0029-6562
AD  - Scientific Director, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 9610645.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107276257&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107275035
T1  - Caring for children awaiting heart transplantation: psychosocial implications.
AU  - Hanton LB
Y1  - 1998/05//1998 May-Jun
N1  - Accession Number: 107275035. Language: English. Entry Date: 19980801. Revision Date: 20150818. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7505804. 
KW  - Heart Transplantation -- Psychosocial Factors -- In Infancy and Childhood
KW  - Preoperative Period
KW  - Child, Hospitalized -- Psychosocial Factors
KW  - Child
KW  - Female
KW  - Education, Continuing (Credit)
KW  - Lazarus Theory of Stress and Coping
KW  - Stress, Psychological -- Etiology -- In Infancy and Childhood
KW  - Inpatients
KW  - Parents -- Psychosocial Factors
KW  - Support, Psychosocial
KW  - Nursing Staff, Hospital -- Psychosocial Factors
SP  - 214
EP  - 227
JO  - Pediatric Nursing
JF  - Pediatric Nursing
JA  - PEDIATR NURS
VL  - 24
IS  - 3
CY  - Pitman, New Jersey
PB  - Jannetti Publications, Inc.
AB  - Heart transplantation presents an extremely stressful life transition for pediatric recipients and their families. The waiting period of the preoperative stage has been described as the most stressful aspect of the process. The stress and coping model of Lazarus and Folkman (1984) can be used as a conceptual framework for addressing stressors of pediatric transplant patients and their families. A case study of a preadolescent child awaiting heart transplantation in a hospital outside of a transplant center highlights common concerns, including feelings of isolation, depression, boredom, hopelessness, helplessness, exhaustion, lack of privacy, financial burdens, role strain, and family disruption. Psychosocial needs can be assessed and met, using a multidisciplinary approach. Because the preoperative stage can be stressful for nurses as well, the case study also explores the struggles of unit nurses trying to coordinate and manage the patient's care.
SN  - 0097-9805
AD  - Staff Nurse, Clinical Nurse III, National Institutes of Health, Bethesda, MD
U2  - PMID: 9987419.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107180336
T1  - Plenary lecture. Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: lessons learned from the Pima Indians.
AU  - Pratley RE
Y1  - 1998/05//
N1  - Accession Number: 107180336. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 7505881. 
KW  - Diabetes Mellitus, Type 2 -- Familial and Genetic
KW  - Diabetes Mellitus, Type 2 -- Etiology
KW  - Native Americans -- Arizona
KW  - Arizona
KW  - Diabetes Mellitus, Type 2 -- Epidemiology
KW  - Prevalence
KW  - Diet
KW  - Obesity
KW  - Physical Activity
KW  - Life Style
KW  - Risk Factors
KW  - Genetics
KW  - Environment
KW  - Prospective Studies
SP  - 175
EP  - 181
JO  - Proceedings of the Nutrition Society
JF  - Proceedings of the Nutrition Society
JA  - PROC NUTR SOC
VL  - 57
IS  - 2
PB  - Cambridge University Press
SN  - 0029-6651
AD  - Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, Arizona 85016
U2  - PMID: 9656318.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107180336&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wiener, Lori S.
T1  - Telephone Support Groups for HIV-Positive Mothers Whose Children Have Died of AIDS.
JO  - Social Work
JF  - Social Work
Y1  - 1998/05//
VL  - 43
IS  - 3
M3  - Article
SP  - 279
EP  - 285
PB  - Oxford University Press / USA
SN  - 00378046
AB  - This article presents the author's comments regarding the effectiveness of telephone support groups for HIV-positive mothers whose children have died of AIDS. Identification and universality have been described by several authors as key elements to support groups. Lieberman, in his study of widow support groups, indicated that the members attached a new social meaning to the loss through normalization, a process of perceiving that one's thoughts, feelings, and behavior are not aberrant or unusual but are common to those undergoing the same experience. I strongly recommend this psychotherapeutic modality to all social workers involved in the HIV epidemic. It is a practical, cost-effective, and therapeutically sound means of reaching people who may not geographically or emotionally be ready to attend face-to-face groups. Telephone support also can allow social workers to reach a population of clients whose connection to an agency is often terminated after the death of a family member. The members of this particular group reported the experience to be an invaluable resource during the intense bereavement period. Group cohesiveness, self-understanding, and the sharing of both wisdom and hope was clearly evident throughout each session.
KW  - SUPPORT groups
KW  - LOSS (Psychology)
KW  - BEREAVEMENT
KW  - HIV-positive women
KW  - CHILDREN -- Death
KW  - CHILDREN of AIDS patients
N1  - Accession Number: 599585; Wiener, Lori S. 1; Email Address: wienerl@pbmac.nci.nih.gov; Affiliation:  1: Coordinator, Pediatric HIV Psychosocial Support Program, National Cancer Institute, National Institutes of Health, Bethesda, MD; Source Info: May98, Vol. 43 Issue 3, p279; Subject Term: SUPPORT groups; Subject Term: LOSS (Psychology); Subject Term: BEREAVEMENT; Subject Term: HIV-positive women; Subject Term: CHILDREN -- Death; Subject Term: CHILDREN of AIDS patients; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 5033
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=599585&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107288871
T1  - Telephone support groups for HIV-positive mothers whose children have died of AIDS.
AU  - Wiener LS
Y1  - 1998/05//
N1  - Accession Number: 107288871. Language: English. Entry Date: 20050425. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 2984852R. 
KW  - Teleconferencing
KW  - Support Groups
KW  - Mothers
KW  - Acquired Immunodeficiency Syndrome -- In Infancy and Childhood
KW  - Death
KW  - Empowerment
KW  - Family Relations
KW  - Attitude to AIDS
KW  - Social Isolation
KW  - Attitude to Death
KW  - Social Attitudes
KW  - Bereavement
KW  - Stigma
KW  - Social Work
KW  - Child, Preschool
KW  - Child
KW  - Adult
KW  - Female
SP  - 279
EP  - 285
JO  - Social Work
JF  - Social Work
JA  - SOC WORK
VL  - 43
IS  - 3
PB  - Oxford University Press / USA
SN  - 0037-8046
AD  - Coordinator, Pediatric HIV Psychosocial Support Program, National Cancer Institute, National Institutes of Health, Bethesda, MD; e-mail: wienerl@pbmac.nci.nih.gov
U2  - PMID: 9597947.
DO  - sw/43.3.279
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288871&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Cardillo, C.
AU  - Panza, J.A.
T1  - Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension.
JO  - Vascular Medicine
JF  - Vascular Medicine
Y1  - 1998/05//
VL  - 3
IS  - 2
M3  - Article
SP  - 138
EP  - 144
PB  - Sage Publications, Ltd.
SN  - 1358863X
AB  - The discovery of the endothelium as a major regulator of vascular tone triggered intense research among basic and clinical investigators to unravel the physiologic and patho-physiologic significance of this phenomenon. Importantly, endothelial modulation of the contractile state of vascular smooth muscle has been shown to be impaired in atherosclerosis and in several conditions known to be associated with the premature development of atherosclerosis. Studies in several different animal models of arterial hypertension, and in patients with both essential and secondary hypertension, have demonstrated an association between elevated systemic blood pressure and impaired endothelium-dependent vascular relaxation. More recently, a diminished bioavailability of nitric oxide (NO) has been identified as a mechanism responsible for endothelial dysfunction in hypertensive patients. Different processes may, in turn, explain this decreased vascular activity of NO. The present review focuses on those clinical studies that are aimed at identifying the precise abnormality responsible for reduced NO-dependent vasodilation in patients with essential hypertension. Understanding of the basic mechanisms of this process may prove to be beneficial for the development of more specific therapies and ultimately for the outcome of hypertensive patients. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Vascular Medicine is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VASCULAR endothelium
KW  - HYPERTENSION
KW  - NITRIC oxide
KW  - blood vessels
KW  - endothelium
KW  - hypertension
KW  - nitric oxide
N1  - Accession Number: 4160852; Cardillo, C. 1 Panza, J.A. 1; Affiliation:  1: Vascular Physiology Laboratory, Section on Echocardiography, Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA; Source Info: 1998, Vol. 3 Issue 2, p138; Subject Term: VASCULAR endothelium; Subject Term: HYPERTENSION; Subject Term: NITRIC oxide; Author-Supplied Keyword: blood vessels; Author-Supplied Keyword: endothelium; Author-Supplied Keyword: hypertension; Author-Supplied Keyword: nitric oxide; Number of Pages: 7p; Illustrations: 2 Diagrams; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=4160852&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 2008-09765-001
AN  - 2008-09765-001
AU  - Harnack, Lisa
AU  - Block, Gladys
AU  - Subar, Amy
AU  - Lane, Sylvia
T1  - Cancer prevention-related nutrition knowledge, beliefs, and attitudes of U.S. adults: 1992 NHIS Cancer Epidemiology Supplement.
JF  - Journal of Nutrition Education
JO  - Journal of Nutrition Education
JA  - J Nutr Educ
Y1  - 1998/05//
VL  - 30
IS  - 3
SP  - 131
EP  - 138
CY  - Canada
PB  - BC Decker
SN  - 0022-3182
AD  - Harnack, Lisa, Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN, US, 55454-1015
N1  - Accession Number: 2008-09765-001. Other Journal Title: Journal of Nutrition Education and Behavior. Partial author list: First Author & Affiliation: Harnack, Lisa; Division of Epidemiology, University of Minnesota, Minneapolis, MN, US. Other Publishers: Elsevier Science. Release Date: 20090706. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Eating Behavior; Health Attitudes; Health Knowledge; Neoplasms; Nutrition. Minor Descriptor: Prevention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 1998. 
AB  - The objective of this study was to describe the cancer prevention-related nutrition knowledge, beliefs, and attitudes of U.S. adults. Data collected for the 1992 National Health Interview Survey Cancer Epidemiology Supplement were analyzed. The Supplement was completed by 12,005 adults aged 18 years and older. Frequency distributions were calculated. Logistic regression analyses were conducted to explore differences in knowledge, beliefs, and attitudes according to selected factors. Most adults (83%) believe that good eating habits may reduce their chances of developing major diseases. Of those who held this belief, 66% named cancer as a disease that might be related to what people eat or drink. Among those who believed cancer to be related to what people eat or drink, eating more fiber (72%), more fruits and vegetables (66%), and less fat (60%) were mentioned most frequently as foods/nutrients that affect cancer risk. Conflicting dietary advice, cost of eating a healthy diet, and social support were the most salient perceived barriers to having a healthful diet. Knowledge, beliefs, and attitudes were found to vary by age, sex, ethnicity, poverty, and education. Findings suggest that, although a moderate majority are aware of the relationship between diet and cancer, fewer are knowledgeable about nutrients/foods that influence risk. Differences found in knowledge, beliefs, and attitudes by various socioeconomic factors suggest that nutrition intervention strategies may need to be targeted and tailored to various population subgroups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cancer prevention
KW  - nutrition knowledge
KW  - health beliefs
KW  - health attitudes
KW  - eating habits
KW  - 1998
KW  - Eating Behavior
KW  - Health Attitudes
KW  - Health Knowledge
KW  - Neoplasms
KW  - Nutrition
KW  - Prevention
KW  - 1998
U1  - Sponsor: Harold Dobbs Fellowship for Cancer Research. Recipients: No recipient indicated
U1  - Sponsor: Bay Area Nutrition Center, Young Investigator's Research Grant Program. Recipients: No recipient indicated
U1  - Sponsor: Dowdle Endowment. Other Details: Doctoral Student Support Award. Recipients: No recipient indicated
U1  - Sponsor: Grossman Medical Research Fund. Recipients: No recipient indicated
DO  - 10.1016/S0022-3182(98)70303-6
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09765-001&site=ehost-live&scope=site
UR  - harnack@epivax.epi.umn.edu
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2010-14881-009
AN  - 2010-14881-009
AU  - Mosnaim, A. D.
AU  - Kulaga, H.
AU  - Adams, A. J.
AU  - Wolf, M. E.
AU  - Puente, J.
AU  - Freitag, F.
AU  - Diamond, S.
T1  - Flow cytometric analysis of lymphocyte subsets in migraine patients during and outside of an acute headache attack.
JF  - Cephalalgia
JO  - Cephalalgia
JA  - Cephalalgia
Y1  - 1998/05//
VL  - 18
IS  - 4
SP  - 197
EP  - 201
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0333-1024
SN  - 1468-2982
AD  - Mosnaim, A. D., Finch University of Health Sciences, Chicago Medical School, 3333 Green Bay Road, N. Chicago, IL, US
N1  - Accession Number: 2010-14881-009. PMID: 9642494 Partial author list: First Author & Affiliation: Mosnaim, A. D.; Department of Pharmacology and Molecular Biology, Chicago Medical School, N. Chicago, IL, US. Other Publishers: Sage Publications. Release Date: 20101025. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aura; Headache; Lymphocytes; Migraine Headache. Minor Descriptor: Patients; Volunteers. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: May, 1998. Publication History: Accepted Date: Feb 18, 1998; First Submitted Date: Sep 25, 1997. 
AB  - We have conducted flow cytometric studies of two subsets of lymphocyte markers in groups of migraineurs during (n = 12; group B) and outside (n = 10; group C) of a migraine without aura attack (total n = 22; group A), including a group of patients tested in both of these phases (n = 5; group D), and compared these results with those obtained from a population of age-comparable, sex- and race-matched healthy volunteers (n = 12; group E). Comparison of the first set of lymphocytes (CD3+CD16+56+, CD3-CD16+56+, CD3-CD19+, CD3+CD19+, and CD3+HLA-DR+) between the patients in group A and the controls (group E) showed differences, reflecting greater group A percentages of CD3+CD16+CD56+ and CD3-CD19+ lymphocytes. Furthermore, these differences reached statistical significance only for the CD3+CD16+CD56+ lymphocytes, and then solely for the patients in group C (Scheffe's test, p< 0.05). Paired analysis of the above lymphocyte markers for subjects in group D failed to show significant differences between patients when they were having and not having a migraine attack, raising the possibility that results from a larger study could show meaningful increases in percentages of CD3+CD16+CD56+ lymphocytes as one of the immune parameters useful for differentiating migraineurs from controls. Comparison of a second set of lymphocyte markers (CD19+CD5+, CD20+CD72-, CD20-CD72+, CD20+CD72+) among either the different groups of patients or between the patients and controls failed, however, to show statistically significant differences, emphasizing the apparent specificity of the findings described above for CD3+CD16+CD56+ lymphocytes. Our results, albeit of a preliminary nature, suggest the occurrence of significant, differential changes in lymphocyte subset immunophenotyping between groups of pain-free migraineurs and patients during an acute migraine episode or controls. Corroboration of these findings may prove useful in clinical laboratory practice to identify changes in immunological parameters specifically associated with migraineurs, and help towards a better understanding of the etiology and pathophysiology of this condition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - flow cytometric analysis
KW  - lymphocyte subsets
KW  - migraine patients
KW  - aura
KW  - healthy volunteers
KW  - acute headache attack
KW  - 1998
KW  - Aura
KW  - Headache
KW  - Lymphocytes
KW  - Migraine Headache
KW  - Patients
KW  - Volunteers
KW  - 1998
U1  - Sponsor: National Headache, Foundation, US. Recipients: No recipient indicated
DO  - 10.1046/j.1468-2982.1998.1804197.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-14881-009&site=ehost-live&scope=site
UR  - mosnaima@mis.finchcms.edu
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-16117-003
AN  - 2005-16117-003
AU  - Ochedalski, Tomasz
AU  - Rabadan-Diehl, Cristina
AU  - Aguilera, Greti
T1  - Interaction Between Glucocorticoids and Corticotropin Releasing Hormone (CRH) in the Regulation of the Pituitary CRH Receptor in vivo in the Rat.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1998/05//
VL  - 10
IS  - 5
SP  - 363
EP  - 369
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - Aguilera, Greti, Section of Endocrine Physiology, Development Endocrinology Branch, NICHD, NIH, Building 10, Room 10, N 262, 10 Center Drive, MSC 1862, Bethesda, MD, US, 20892-1862
N1  - Accession Number: 2005-16117-003. PMID: 9663650 Partial author list: First Author & Affiliation: Ochedalski, Tomasz; Section of Endocrine Physiology, Development Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Corticotropin; Glucocorticoids; Hormones; Rats. Minor Descriptor: Neural Receptors; Stress. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: May, 1998. 
AB  - Acute stress causes biphasic changes in corticotropin releasing hormone (CRH) receptor mRNA expression with an early decrease followed by an increase. However, in the absence of glucocorticoids in adrenalectomized rats, stress results in prolonged CRH receptor (CRH-R) mRNA loss, suggesting that interactions between glucocorticoids and hypothalamic factors are critical for regulation of CRH receptor mRNA. To address this question, CRH binding, type-1 CRH-R mRNA, POMC mRNA and POMC mRNA expression were measured by binding autoradiography and in situ hybridization in pituitaries from intact and adrenalectomized rats. CRH-R mRNA decreased by 59% 5 h after injection of corticosterone (10 mg sc) and returned to basal levels by 18 h, a time when plasma corticosterone concentrations were still elevated, and CRH binding and POMC mRNA were significantly reduced. Elevations in plasma corticosterone in the range of acute stress by injection of 2 mg sc caused CRH-R mRNA expression to return to near basal values by 6 h, after a 52% and 39% decrease at 2 h and 4 h. More transient changes were seen after a single injection of CRH (1 μg), with a 44% decrease in CRH-R mRNA and a 175% increase in POMC mRNA by 2 h, returning to basal values by 4 h. The transient effect of CRH was not due to clearance of CRH from the circulation or receptor desensitization since CRH receptor mRNA expression also recovered after injection of a higher dose (10 μg) or repeated injections of CRH which caused sustained increases in plasma CRH and pituitary POMC mRNA levels. CRH injection in adrenalectomized rats decreased CRH-R mRNA for up to 6 h, suggesting that glucocorticoids are permissive for the recovery of CRH-R mRNA. Supporting this hypothesis, simultaneous injection of corticosterone and CRH restored CRH-R mRNA expression by 4 h, and increased CRH binding 4 h and 6 h after injection. The data show that interaction between CRH and glucocorticoids counteracts individual inhibitory effects of these regulators alone, and that such effects are likely to contribute to the regulatory pattern of pituitary CRH receptors during acute stress. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glucocorticoids
KW  - corticotropin releasing hormone
KW  - rats
KW  - hypothalamic factors
KW  - hormone receptor
KW  - acute stress
KW  - 1998
KW  - Corticotropin
KW  - Glucocorticoids
KW  - Hormones
KW  - Rats
KW  - Neural Receptors
KW  - Stress
KW  - 1998
DO  - 10.1046/j.1365-2826.1998.00212.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16117-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13476-020
AN  - 2008-13476-020
AU  - Gressens, Pierre
AU  - Paindaveine, Bénédicte
AU  - Hill, Joanna M.
AU  - Evrard, Philippe
AU  - Brenneman, Douglas E.
T1  - Vasoactive intestinal peptide shortens both G1 and S phases of neural cell cycle in whole postimplantation cultured mouse embryos.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/05//
VL  - 10
IS  - 5
SP  - 1734
EP  - 1742
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Gressens, Pierre, Service de Neurologie Pediatrique, Hopital Robert-Debre, 48 Blvd Serurier, F-75019, Paris, France
N1  - Accession Number: 2008-13476-020. PMID: 9751145 Partial author list: First Author & Affiliation: Gressens, Pierre; Service de Neuropediatrie, Hopital Robert-Debre, Paris, France. Other Publishers: Blackwell Publishing. Release Date: 20090105. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neural Development; Neurons; Peptides; Neurotrophic Factor. Minor Descriptor: Embryo; Intestines; Mice. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 1998. 
AB  - Vasoactive intestinal peptide, a trophic and mitogenic factor, stimulates growth in whole cultured mouse embryos. Inhibition of this growth function between embryonic days 9 and 11 induces growth retardation accompanied by severe microcephaly. In the present study, to determine the effects of this peptide on the different phases of the cell cycle of neural cells, embryonic day 9.5 cultured mouse embryos were cumulatively labelled with bromodeoxyuridine. Vasoactive intestinal peptide (10-7M) shortened S phase and G1 phase of neuroepithelial cells by 50% (4.8-2.4 h) and 58% (1.9-0.8 h), respectively, compared with controls. G2 and M phases were not modified by vasoactive intestinal peptide treatment. Total cell cycle length was consequently reduced by 43% (8.2-4.7 h) in vasoactive intestinal peptide treated embryos, compared with controls. In contrast, vasoactive intestinal peptide did not modify the rate of neuroepithelial cell death as assessed by the proportion of nuclei containing fragmented DNA. These data suggest that vasoactive intestinal peptide stimulates growth in premigratory stages of nervous system development by shortening S and G1 phases of the cell cycle and that S phase duration can be regulated by a physiological peptide. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - vasoactive intestinal peptide
KW  - neural cell cycle
KW  - mouse embryos
KW  - growth factor
KW  - neuroepithelium
KW  - neurogenesis
KW  - pituitary adenylate cyclase activating polypeptide
KW  - 1998
KW  - Neural Development
KW  - Neurons
KW  - Peptides
KW  - Neurotrophic Factor
KW  - Embryo
KW  - Intestines
KW  - Mice
KW  - 1998
U1  - Sponsor: Institut National de la Santé et de la Recherche Médicale, France. Recipients: No recipient indicated
U1  - Sponsor: Fondation de France, France. Recipients: No recipient indicated
DO  - 10.1046/j.1460-9568.1998.00172.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13476-020&site=ehost-live&scope=site
UR  - pierre.gressens@rdb.ap-hop-paris.fr
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13476-024
AN  - 2008-13476-024
AU  - Serafini, Ruggero
AU  - Ma, Wu
AU  - Maric, Dragan
AU  - Maric, Irina
AU  - Lahjouji, Fatiha
AU  - Sieghart, Werner
AU  - Barker, Jeffery L.
T1  - Initially expressed early rat embryonic GABAA receptor Cl- ion channels exhibit heterogeneous channel properties.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/05//
VL  - 10
IS  - 5
SP  - 1771
EP  - 1783
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Maric, Dragan, Laboratory of Neurophysiology, NINDS/NIH, Bldg 36, Room 2602, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13476-024. PMID: 9751149 Partial author list: First Author & Affiliation: Serafini, Ruggero; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090105. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Serafini, Ruggero. Major Descriptor: Gamma Aminobutyric Acid; Neural Receptors; Spinal Cord; Ion Channel. Minor Descriptor: Electrophysiology; Embryo; Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: May, 1998. 
AB  - We have studied the earliest expression of GABA-induced Cl- channels in the rat embryonic dorsal spinal cord (DSC) using in situ hybridization, immunocytochemistry, flow cytometry and electrophysiology. At embryonic day 13 (E13) cells in the dorsal region are still proliferating. In situ hybridization consistently showed transcripts encoding only three GABAA receptor subunits (α₄, β₁ and γ₁); immunocytochemistry both in tissue sections and in acutely isolated cells in suspension demonstrated the expression of the corresponding proteins and also revealed staining for other subunits (α₂, α₃, β₃, γ₂). In patch-recordings performed in cells acutely isolated from the dorsal cord, responses to GABA were detected in 356 out of 889 cells. GABA-evoked responses, which often displayed the opening of a few channels, were mediated by Cl- ions, were inhibited by bicuculline and picrotoxin, and potentiated by benzodiazepines. Taken together, these observations indicate that Cl- channels likely involve GABAA type receptors. Fluctuation analysis revealed channel kinetics consisting of three exponential components (τs: ≈ 1, 9 and 90 ms) and a wide variety of inferred unitary conductance values, ranging between 4 and 40 pS. A comparison of these results with observations in other, later embryonic cell types and recombinant receptors suggests that most of the earliest E13 DSC GABAA receptors may include α₃ subunit. These GABAA receptor Cl- channels may be activated physiologically as both GABA synthesizing enzymes and GABA are present in the E13 dorsal cord. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - rat embryonic GABA receptors
KW  - ion channels
KW  - heterogeneous channel properties
KW  - dorsal spinal cord
KW  - hybridization
KW  - immunocytochemistry
KW  - flow cytometry
KW  - electrophysiology
KW  - 1998
KW  - Gamma Aminobutyric Acid
KW  - Neural Receptors
KW  - Spinal Cord
KW  - Ion Channel
KW  - Electrophysiology
KW  - Embryo
KW  - Rats
KW  - 1998
U1  - Sponsor: EEC. Other Details: Scholarship. Recipients: Serafini, Ruggero
U1  - Sponsor: Regione Abruzzo, Italy. Other Details: Through CMNS Mario Negri Sud, S. Maria Imbaro. Recipients: No recipient indicated
DO  - 10.1046/j.1460-9568.1998.00187.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13476-024&site=ehost-live&scope=site
UR  - Dragan@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13476-034
AN  - 2008-13476-034
AU  - Sills, Terrence L.
AU  - Onalaja, Ava O.
AU  - Crawley, Jacqueline N.
T1  - Mesolimbic dopaminergic mechanisms underlying individual differences in sugar consumption and amphetamine hyperlocomotion in Wistar rats.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/05//
VL  - 10
IS  - 5
SP  - 1895
EP  - 1902
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Sills, Terrence L., Biophysiology Section, Clarke Institute of Psychiatry, 250 College Street, Toronto, ON, Canada, M5T 1R8
N1  - Accession Number: 2008-13476-034. PMID: 9751159 Partial author list: First Author & Affiliation: Sills, Terrence L.; Section on Behavioural Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090105. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amphetamine; Animal Feeding Behavior; Animal Locomotion; Dopamine; Sugars. Minor Descriptor: Dopamine Agonists; Individual Differences; Quinpirole; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 1998. 
AB  - Individual differences within strains of rats have been demonstrated for dopamine-mediated behaviours and responses to dopaminergic drugs. Differences in mesolimbic dopamine function may underlie individual differences in some of these behaviours, including sugar consumption and amphetamine hyperlocomotion. The present study addressed two potential mechanisms for these differences in dopamine-mediated behaviours. The possibility of functional differences in dopamine receptor subtypes was tested in LOW and HIGH sugar feeders. LOW and HIGH feeders did not differ in their response to the partial D₁ agonist SKF-38393. The highest dose (2.5 mg/kg) of the D₂ agonist quinpirole stimulated locomotor activity to a greater degree in a subset of HIGH sugar feeders as compared with LOW feeders. All doses of amphetamine induced a greater locomotor response in HIGH feeders as compared with LOW feeders, and HIGH feeders exhibited higher levels of extracellular dopamine in the nucleus accumbens than LOW feeders following exposure to sugar and treatment with amphetamine. These results support the interpretation that LOW and HIGH feeders exhibit differences in presynaptic nucleus accumbens dopamine function that account for the expression of individual differences in sugar consumption and response to amphetamine treatments. A subset of HIGH feeders may also exhibit greater D₂ receptor function. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mesolimbic dopaminergic mechanisms
KW  - individual differences
KW  - sugar consumption
KW  - amphetamine hyperlocomotion
KW  - Wistar rats
KW  - quinpirole
KW  - SKF-38393
KW  - 1998
KW  - Amphetamine
KW  - Animal Feeding Behavior
KW  - Animal Locomotion
KW  - Dopamine
KW  - Sugars
KW  - Dopamine Agonists
KW  - Individual Differences
KW  - Quinpirole
KW  - Rats
KW  - 1998
DO  - 10.1046/j.1460-9568.1998.00201.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13476-034&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40560-021
AN  - 2015-40560-021
AU  - Morsli, Hakim
AU  - Choo, Daniel
AU  - Ryan, Allen
AU  - Johnson, Randy
AU  - Wu, Doris K.
T1  - Development of the mouse inner ear and origin of its sensory organs.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/05//
VL  - 18
IS  - 9
SP  - 3327
EP  - 3335
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wu, Doris K., National Institute on Deafness and Other Communication Disorders, 5 Research Court, Room 2B34, Rockville, MD, US, 20850
N1  - Accession Number: 2015-40560-021. PMID: 9547240 Partial author list: First Author & Affiliation: Morsli, Hakim; National Institute on Deafness and Other Communication Disorders, Rockville, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ryan, Allen. Major Descriptor: Labyrinth (Anatomy); Physiology; Proteins; Sensory Integration. Minor Descriptor: Mice. Classification: Physiological Processes (2540). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: May, 1998. Publication History: Accepted Date: Feb 23, 1998; Revised Date: Feb 18, 1998; First Submitted Date: Dec 15, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - The molecular mechanisms dictating the morphogenesis and differentiation of the mammalian inner ear are largely unknown. To better elucidate the normal development of this organ, two approaches were taken. First, the membranous labyrinths of mouse inner ears ranging from 10.25 to 17 d postcoitum (dpc) were filled with paint to reveal their gross development. Particular attention was focused on the developing utricle, saccule, and cochlea. Second, we used bone morphogenetic protein 4 (BMP4) and lunatic fringe (Fng) as molecular markers to identify the origin of the sensory structures. Our data showed that BMP4 was an early marker for the superior, lateral, and posterior cristae, whereas Fng served as an early marker for the macula utriculi, macula sacculi, and the sensory portion of the cochlea. The posterior crista was the first organ to appear at 11.5 dpc and was followed by the superior crista, the lateral crista, and the macula utriculi at 12 dpc. The macula sacculi and the cochlea were present at 12 dpc but became distinguishable from each other by 13 dpc. Based on the gene expression patterns, the anterior and lateral cristae may share a common origin. Similarly, three sensory organs, the macula utriculi, macula sacculi, and cochlea, seem to arise from a single region of the otocyst. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - inner ear development
KW  - sensory organs
KW  - lunatic fringe
KW  - BMP4
KW  - NT-3
KW  - Brn3.1
KW  - 1998
KW  - Labyrinth (Anatomy)
KW  - Physiology
KW  - Proteins
KW  - Sensory Integration
KW  - Mice
KW  - 1998
U1  - Sponsor: National Institutes of Health, National Institute on Deafness and Other Communication Disorders, US. Grant: DC00139. Recipients: Ryan, Allen
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40560-021&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40560-032
AN  - 2015-40560-032
AU  - Chen, Robert
AU  - Corwell, Brian
AU  - Yaseen, Zaneb
AU  - Hallett, Mark
AU  - Cohen, Leonardo G.
T1  - Mechanisms of cortical reorganization in lower-limb amputees.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/05//
VL  - 18
IS  - 9
SP  - 3443
EP  - 3450
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Cohen, Leonardo G., National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N234, 10 Center Drive, MSC-1430, Bethesda, MD, US, 20892-1430
N1  - Accession Number: 2015-40560-032. PMID: 9547251 Partial author list: First Author & Affiliation: Chen, Robert; Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amputation; Motor Cortex; Motor Processes; Transcranial Magnetic Stimulation. Minor Descriptor: Neural Plasticity. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: May, 1998. Publication History: Accepted Date: Feb 17, 1998; Revised Date: Feb 13, 1998; First Submitted Date: Nov 19, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - The human motor system undergoes reorganization after amputation, but the site of motor reorganization and the mechanisms involved are unknown. We studied the site and mechanisms of motor reorganization in 16 subjects with traumatic lower-limb amputation. Stimulation at different levels in the CNS was used to determine the site of reorganization. The mechanisms involved were evaluated by measuring the thresholds for transcranial magnetic stimulation (TMS) and by testing intracortical inhibition and facilitation. With TMS, the threshold for muscle activation on the amputated side was lower than that of the intact side, but with transcranial electrical stimulation there was no difference in motor threshold between the two sides. TMS at the maximal output of the stimulator activated a higher percentage of the motor neuron pool (%MNP) on the amputated side than on the intact side. The %MNP activated by spinal electrical stimulation was similar on the two sides. Paired TMS study showed significantly less intracortical inhibition on the amputated side. Our findings suggest that motor reorganization after lower-limb amputation occurs predominately at the cortical level. The mechanisms involved are likely to include reduction of GABAergic inhibition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - amputation
KW  - motor reorganization
KW  - mechanisms of plasticity
KW  - human
KW  - transcranial magnetic stimulation
KW  - motor cortex
KW  - 1998
KW  - Amputation
KW  - Motor Cortex
KW  - Motor Processes
KW  - Transcranial Magnetic Stimulation
KW  - Neural Plasticity
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40560-032&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40561-014
AN  - 2015-40561-014
AU  - Rajan, Prithi
AU  - McKay, Ronald D. G.
T1  - Multiple routes to astrocytic differentiation in the CNS.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/05//
VL  - 18
IS  - 10
SP  - 3620
EP  - 3629
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - McKay, Ronald D. G., Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5A29, Bethesda, MD, US, 20892-4157
N1  - Accession Number: 2015-40561-014. PMID: 9570793 Partial author list: First Author & Affiliation: Rajan, Prithi; Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Astrocytes; Cell Signaling; Neurotrophic Factor; Cell Differentiation. Minor Descriptor: Mitogen Activated Protein Kinase; Transcription Factors. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: May, 1998. Publication History: Accepted Date: Feb 20, 1998; Revised Date: Feb 19, 1998; First Submitted Date: Nov 17, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Ciliary neurotrophic factor (CNTF) acts instructively to switch multipotent stem cells of the CNS to an astrocytic fate. Here we show that CNTF causes activation of janus kinase–signal transducers and activators of transcription and mitogen-activated protein kinase (MAPK) pathways with differential kinetics in these cells. Inhibition studies indicate that activation of the MAPK pathway is required early in the differentiation process, whereas activation of signal transducer and activator of transcription (STAT) proteins is required for commitment to an astrocytic fate. Bone morphogenetic proteins have also been shown to cause astrocytic differentiation but do not cause STAT activation or astrocytic differentiation in fibroblast growth factor 2-expanded fetal stem cells used here. These results show that there are two distinct routes to initiate astrocytic commitment in multipotent CNS precursors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - astrocytic differentiation
KW  - CNS stem cells
KW  - mammalian CNS development
KW  - intracellular signaling
KW  - CNTF
KW  - BMP4
KW  - EGF
KW  - 1998
KW  - Central Nervous System
KW  - Astrocytes
KW  - Cell Signaling
KW  - Neurotrophic Factor
KW  - Cell Differentiation
KW  - Mitogen Activated Protein Kinase
KW  - Transcription Factors
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40561-039
AN  - 2015-40561-039
AU  - Dijkstra, Ivar
AU  - Tilders, Fred J. H.
AU  - Aguilera, Greti
AU  - Kiss, Alexander
AU  - Rabadan-Diehl, Cristina
AU  - Barden, Nicholas
AU  - Karanth, Sharada
AU  - Holsboer, Florian
AU  - Reul, Johannes M. H. M.
T1  - Reduced activity of hypothalamic corticotropin-releasing hormone neurons in transgenic mice with impaired glucocorticoid receptor function.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/05//
VL  - 18
IS  - 10
SP  - 3909
EP  - 3918
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Tilders, Fred J. H., Research Institute Neurosciences, Vrije Universiteit, Faculty of Medicine, Department of Pharmacology, van der Boechorststraat 7, 1081 BT, Amsterdam, Netherlands
N1  - Accession Number: 2015-40561-039. PMID: 9570818 Partial author list: First Author & Affiliation: Dijkstra, Ivar; Graduate School Neurosciences Amsterdam, Department of Pharmacology, Research Institute Neurosciences, Vrije Universiteit, Amsterdam, Netherlands. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Corticosterone; Corticotropin Releasing Factor; Glucocorticoids; Hypothalamus; Neural Receptors. Minor Descriptor: Mental Disorders; Mice; mRNA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: May, 1998. Publication History: Accepted Date: Mar 3, 1998; Revised Date: Feb 27, 1998; First Submitted Date: Dec 31, 1997. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Loss of central glucocorticoid receptor (GR) function is thought to be involved in the development of neuroendocrine and psychiatric disorders associated with corticotropin-releasing hormone (CRH) hyperactivity. The possible causal relationship between defective GR function and altered activity of CRH neurons was studied in transgenic mice (TG) expressing antisense RNA against GR. Immunocytochemical studies showed significant reductions in CRH immunoreactive neurons in the paraventricular nucleus (PVN) and in CRH and vasopressin (AVP) stores in the external zone of the median eminence. Concomitantly, stimulus-evoked CRH secretion from mediobasal hypothalami of TG mice in vitro was reduced significantly. However, CRH mRNA levels in the PVN of TG mice were marginally lower than those in wild-type (WT) mice. ¹²⁵I-CRH binding autoradiography revealed no differences between WT and TG animals in any of the brain regions that were studied. Basal plasma corticosterone (cort) levels and ¹²⁵I-CRH binding, CRH-R1 mRNA, POMC mRNA, and POMC hnRNA levels in the anterior pituitary gland were similar in WT and TG mice. Intraperitoneal injection of interleukin-1β (IL-1β) increased plasma cort levels, CRH mRNA in the PVN, and anterior pituitary POMC hnRNA similarly in WT and TG mice. The injection of saline significantly reduced anterior pituitary CRH-R₁ mRNA levels in WT mice, but not in TG mice, whereas IL-1β produced a decrease in these mRNA levels in both strains. The data show that long-term GR dysfunction can be associated with reduced activity of CRH neurons in the PVN and decreased sensitivity of pituitary CRH-R₁ mRNA to stimulus-induced downregulation. Moreover, the hypothalamic changes observed in this model suggest that impaired GR function, at least if present since early embryonic life, does not necessarily result in CRH hyperexpression characteristics of disorders such as major depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - corticotropin-releasing hormone (CRH)
KW  - glucocorticoid receptor (GR)
KW  - transgenic (TG) mice
KW  - IL-1b
KW  - paraventricular nucleus
KW  - HPA axis
KW  - CRH receptor
KW  - 1998
KW  - Corticosterone
KW  - Corticotropin Releasing Factor
KW  - Glucocorticoids
KW  - Hypothalamus
KW  - Neural Receptors
KW  - Mental Disorders
KW  - Mice
KW  - mRNA
KW  - 1998
U1  - Sponsor: Dutch Foundation for Scientific Research, Netherlands. Grant: 900-564-034. Recipients: No recipient indicated
U1  - Sponsor: Volkswagen Foundation, Germany. Grant: I/70 543. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Kawauchi, A.
AU  - Imada, N.
AU  - Tanaka, Y.
AU  - Minami, M.
AU  - Watanabe, H.
AU  - Shirakawa, S.
T1  - Changes in the structure of sleep spindles and delta waves on electroencephalography in patients with nocturnal enuresis.
JO  - British Journal of Urology
JF  - British Journal of Urology
Y1  - 1998/05/02/May98 Supplement 3
VL  - 81
M3  - Article
SP  - 72
EP  - 75
PB  - Wiley-Blackwell
SN  - 00071331
AB  - Objective To evaluate the mechanism of the dysfunction of arousal in patients with Type I and Type IIa enuresis. Patients and methods The numbers of sleep spindles and delta waves were analysed during electroencephalography in 19 patients with enuresis (17 male, two female, mean age 9.7 years, range 8–14). Results In four patients with Type I enuresis, who awoke spontaneously and remained dry as a result of urinary sensation, the numbers of sleep spindles and delta waves diminished gradually and finally disappeared just before the patients awoke completely. In the remaining nine patients with Type I enuresis, there was no decrease in the number of sleep spindles and delta waves, and enuresis occurred without the subjects awakening. In the six patients with Type IIa enuresis, there was no arousal reaction or generation of sleep spindles on urination while asleep. Conclusions An immaturity in the function of the thalamus might be a cause of the arousal dysfunction in patients with Type I enuresis. In Type IIa enuresis, a possible abnormal or immature arousal mechanism in the pons or the lower tract may be responsible. [ABSTRACT FROM AUTHOR]
AB  - Copyright of British Journal of Urology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AROUSAL (Physiology)
KW  - ENURESIS
KW  - arousal dysfunction
KW  - Delta wave
KW  - Nocturnal enuresis
KW  - Sleep spindles
KW  - thalamus
N1  - Accession Number: 5721932; Kawauchi, A. 1 Imada, N. 1 Tanaka, Y. 1 Minami, M. 1 Watanabe, H. 1 Shirakawa, S. 2; Affiliation:  1: Department of Urology, Kyoto Prefectural University of Medicine,  2: National Center of Neurology and Psychiatry, National Institute of Mental Health, Japan; Source Info: May98 Supplement 3, Vol. 81, p72; Subject Term: AROUSAL (Physiology); Subject Term: ENURESIS; Author-Supplied Keyword: arousal dysfunction; Author-Supplied Keyword: Delta wave; Author-Supplied Keyword: Nocturnal enuresis; Author-Supplied Keyword: Sleep spindles; Author-Supplied Keyword: thalamus; Number of Pages: 4p; Illustrations: 4 Graphs; Document Type: Article
L3  - 10.1046/j.1464-410X.1998.00012.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107181368
T1  - The impact of a family history of alcoholism on the relationship between age at onset of alcohol use and DSM-IV alcohol dependence: results from the National Longitudinal Alcohol Epidemiologic Survey.
AU  - Grant BF
Y1  - 1998/06//
N1  - Accession Number: 107181368. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0365245. 
KW  - Alcoholism -- Familial and Genetic
KW  - Age Factors
KW  - Data Analysis Software
KW  - DSM
KW  - Whites
KW  - Blacks
KW  - Male
KW  - Female
KW  - Kappa Statistic
KW  - Descriptive Statistics
KW  - Sex Factors
KW  - Race Factors
KW  - Test-Retest Reliability
KW  - Interviews
KW  - United States
KW  - Cluster Sample
KW  - Human
SP  - 144
EP  - 147
JO  - Alcohol Health & Research World
JF  - Alcohol Health & Research World
JA  - ALCOHOL HEALTH RES WORLD
VL  - 22
IS  - 2
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - Both the age at onset of alcohol use and a family history of alcoholism can influence a person's risk of becoming alcohol dependent. The relationship between lifetime alcohol dependence, age at first alcohol use, and a family history of alcoholism was investigated using data obtained in the 1992 National Longitudinal Alcohol Epidemiologic Survey. This analysis demonstrated that regardless of the family history of alcoholism, respondents with an earlier age of drinking onset were more likely to become alcohol dependent compared with respondents with a later age of drinking onset. Among all age, race, and gender subgroups studied, however, people with a family history of alcoholism had a higher prevalence of lifetime alcohol dependence than did people without such a history.
SN  - 0090-838X
AD  - Chief of the Biometry Branch, Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
U2  - PMID: 15706789.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107181368&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107299273
T1  - Risk index for prediction of surgical site infection after oncology operations.
AU  - Velasco E
AU  - Thuler LCS
AU  - de Souza Martins CA
AU  - de Castro Dias LM
AU  - Concalves VMS
Y1  - 1998/06//1998 Jun
N1  - Accession Number: 107299273. Language: English. Entry Date: 19981201. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854. 
KW  - Surgical Wound Infection -- Etiology
KW  - Oncologic Care
KW  - Immunocompromised Host
KW  - Surgical Wound Infection -- Epidemiology
KW  - Fisher's Exact Test
KW  - Prospective Studies
KW  - Epidemiological Research
KW  - Convenience Sample
KW  - T-Tests
KW  - Mann-Whitney U Test
KW  - Chi Square Test
KW  - Logistic Regression
KW  - Correlation Coefficient
KW  - Sensitivity and Specificity
KW  - Descriptive Statistics
KW  - Risk Factors
KW  - Cancer Care Facilities
KW  - Brazil
KW  - Wound Assessment
KW  - Cross Infection -- Epidemiology
KW  - Data Analysis Software
KW  - Age Factors
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Sex Factors
KW  - Antibiotic Prophylaxis
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Inpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 217
EP  - 223
JO  - American Journal of Infection Control
JF  - American Journal of Infection Control
JA  - AM J INFECT CONTROL
VL  - 26
IS  - 3
CY  - New York, New York
PB  - Elsevier Science
AB  - INTRODUCTION: Several studies have shown that surgical site infections represent most hospital-acquired infections, with the major impact being on average hospital stay and cost of hospitalization. METHODS: To develop a risk model for prediction of surgical site infections in cancer patients undergoing operative procedures and identify those with high probability of infection we performed a prospective cohort study in a tertiary cancer care hospital in Rio de Janeiro, Brazil. Risk factors were studied in single and multivariate analyses. RESULTS: Over a 24-month period, 1205 patients underwent operations for malignant disease. The overall surgical site infection rate was 17.3%. A multivariate stepwise logistic regression model identified six independent predictive risk factors: contaminated and infected operations, surgical duration greater than 280 minutes, male sex, prior radiotherapy, American Society of Anesthesiology class III to V, and antimicrobial prophylaxis not according to protocol. On the basis of individual risk scores, two groups of patients were identified: a low-risk (score < or = 8; surgical site infection rate 10%) and a high-risk group (score > or = 9; surgical site infection rate 33.6%; relative risk 3.4; 95% confidence interval 2.6 to 4.4). CONCLUSION: The oncology risk model allowed for the identification of a high-risk score group of patients and implementation of a more efficient and selective intervention program.
SN  - 0196-6553
AD  - Infectious Disease Service and Hospital Infection Control Committee, National Cancer Institute, Rio de Janeiro, Brazil
U2  - PMID: 9638283.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Piscitelli, S. C.;
T1  - Use of immunomodulation for the treatment of HIV infection
CT  - Use of immunomodulation for the treatment of HIV infection
JO  - ASHP Annual Meeting
JF  - ASHP Annual Meeting
Y1  - 1998/06/01/
VL  - 55
IS  - Jun
SP  - PI
EP  - 35
AD  - Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA Internet: spisc@nih.gov
N1  - Accession Number: 35-05366; Language: English; Chemical Name: Thalidomide--50-35-1; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - A variety of immune-based therapies have been studied in HIV-infected patients. These agents are used in conjunction with standard antiretrovirals and the goal of these therapies is to augment, restore, or boost the patient's immune system. Recombinant interleukin-2 has been shown to increase CD4 counts and interleukin-10 has demonstrated potent effects on pro-inflammatory cytokines. Other agents such as thalidomide and monoclonal antibodies have also been evaluated in HIV-infected patients. Other approaches to modulate the immune system include adoptive transfer of t-cells, HIV vaccines, and gene therapy. Theoretically, the combination of antiretrovirals with immunomodulators would be a novel approach to therapy. From a practical standpoint, the difficulty lies in finding agents that can augment the immune system but do not cause viral activation or adverse effects. Learning objectives: 1. List the various immunomodulatory options for HIV infected patients. 2. Discuss the efficacy and toxicity of interleukin-2. 3. Describe the progress to date with HIV vaccines and gene therapy. Self-assessment questions: True or False: 1. A flu-like syndrome is a common side effect of therapy with interleukins and interferons. 2. Thalidomide has been shown to raise CD4 counts in HIV-infected patients. 3. HIV vaccines have shown a very good safety profile to date. Answers: 1. T; 2. F; 3 T.
KW  - Thalidomide--HIV infections-;
KW  - ASHP meeting abstracts--HIV infections, immunotherapy;
KW  - Immunotherapy--HIV infections;
KW  - Interleukins--HIV infections;
KW  - HIV infections--immunotherapy;
KW  - Antiretroviral agents--HIV infections;
KW  - Antibodies--monoclonal--HIV infections;
KW  - Gene therapy--HIV infections;
KW  - Interferons--HIV infections;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107173183
T1  - Focal dystonia and repetitive motion disorders.
AU  - Chen R
AU  - Hallett M
Y1  - 1998/06//1998 Jun
N1  - Accession Number: 107173183. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0075674. 
KW  - Dystonia
KW  - Cumulative Trauma Disorders
KW  - Hand Injuries
KW  - Dystonia -- Physiopathology
KW  - Cumulative Trauma Disorders -- Physiopathology
KW  - Hand Injuries -- Physiopathology
SP  - 102
EP  - 106
JO  - Clinical Orthopaedics & Related Research
JF  - Clinical Orthopaedics & Related Research
JA  - CLIN ORTHOP RELATED RES
VL  - 351
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
SN  - 0009-921X
AD  - Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Modi, W. S.
AU  - Amarante, M. R. V.
AU  - Hanson, M.
AU  - Womack, J. E.
AU  - Chidambaram, A.
T1  - Assignment of the mouse and cow CXC chemokine genes.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/06//
VL  - 81
IS  - 3/4
M3  - Article
SP  - 213
EP  - 216
SN  - 03010171
AB  - Gene specific PCR primers were constructed for five mouse and three bovine CXC chemokine genes. The mouse genes were assigned using SSCP analyses of the Jackson BSS backcross panel to two groups on chromosome 5. One group containing Gro1 and Mip2 cosegregated with reference markers Alb1 and Btc , and was positioned 2.2 cM proximal to a group comprising Ifi10 , Mig , and Scyb5 . The bovine genes IL8, GRO1, and GRO3, mapped using bovine × hamster somatic cell hybrids, were all found to be located on chromosome 6. The locations of these genes in these two animal species are consistent with the positions in humans (4q13→q21), and previous syntenic relationships among these three mammals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cytogenetics & Cell Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHEMOKINES
KW  - LEUCOCYTES
KW  - MICE as laboratory animals
KW  - SOMATIC hybrids
KW  - GENE mapping
KW  - GENETIC research
N1  - Accession Number: 12184224; Modi, W. S. 1; Email Address: modi@mail.neiferf.gov Amarante, M. R. V. 2 Hanson, M. 1 Womack, J. E. 2 Chidambaram, A. 1; Affiliation:  1: SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD.  2: Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A & M University, College Station, TX, USA.; Source Info: Jun98, Vol. 81 Issue 3/4, p213; Subject Term: CHEMOKINES; Subject Term: LEUCOCYTES; Subject Term: MICE as laboratory animals; Subject Term: SOMATIC hybrids; Subject Term: GENE mapping; Subject Term: GENETIC research; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3  - 10.1159/000015033
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107289805
T1  - Eosinophilia in the returning traveler.
AU  - Moore TA
AU  - Nutman TB
Y1  - 1998/06//1998 Jun
N1  - Accession Number: 107289805. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Eosinophilia -- Etiology
KW  - Travel
KW  - Eosinophilia -- Diagnosis
KW  - Eosinophils
KW  - Helminthiasis -- Complications
KW  - Helminthiasis -- Diagnosis
KW  - Parasitic Diseases -- Complications
KW  - Parasitic Diseases -- Diagnosis
SP  - 503
EP  - 521
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 12
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Eosinophilia is one of the most common laboratory abnormalities seen in the returning traveler. Although elevations in peripheral eosinophil levels can occur in a wide variety of disease processes, worldwide, helminth parasites are the major group of infectious agents responsible for eosinophilia. While often directed at helminth infections in their early stages of clinical evolution, the approach to the evaluation of the returning traveler with eosinophilia must consider the many causes of eosinophilia including those not casually related to travel. This article reviews the major parasitic causes of eosinophilia and provides a systematic approach to the evaluation of eosinophilia following travel. Copyright (c) 1998 by W.B. Saunders Company
SN  - 0891-5520
AD  - Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
U2  - PMID: 9658256.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107175971
T1  - Sources of child vocabulary competence: a multivariate model.
AU  - Bornstein MH
AU  - Haynes MO
AU  - Painter KM
Y1  - 1998/06//
N1  - Accession Number: 107175971. Language: English. Entry Date: 19990401. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Early Language Inventory (ELI) (Bates et al); Knowledge of Infant Developmental Inventory (KIDI) (MacPhee); Peabody Picture Vocabulary Test-Revised (PPVT-R); Reynell Developmental Language Scales-Second Revision (RDLS) (Reynell and Huntley); Vineland Adaptive Behavior Scales-Interview Edition, Survey Form (VABS) (Sparrow et al); Self-Perception of the Parental Role (SPPR) (MacPhee et al); Social Desirability Scale (SDS) (Crowne and Marlowe); Jackson Personality Inventory (JPI); Parental Style Questionnaire (PSQ) (Bornstein et al). NLM UID: 0425743. 
KW  - Language Development -- In Infancy and Childhood
KW  - Speech Production Measurement -- In Infancy and Childhood
KW  - Models, Theoretical
KW  - Conceptual Framework
KW  - Infant
KW  - Mothers
KW  - Mother-Infant Relations
KW  - Child Development
KW  - Female
KW  - Male
KW  - Videorecording
KW  - Play and Playthings
KW  - Intraclass Correlation Coefficient
KW  - Forecasting (Research)
KW  - Descriptive Statistics
KW  - Independent Variable
KW  - Socialization
KW  - Chi Square Test
KW  - Sex Factors
KW  - Maternal Role
KW  - Human
SP  - 367
EP  - 393
JO  - Journal of Child Language
JF  - Journal of Child Language
JA  - J CHILD LANG
VL  - 25
IS  - 2
PB  - Cambridge University Press
AB  - This study examines sources of individual variation in child vocabulary competence in the context of a multivariate developmental ecological model. Maternal sociodemographic characteristics, personological characteristics, and vocabulary, as well as child gender, social competence, and vocabulary competence were evaluated simultaneously in 126 children aged 1;8 and their mothers. Measures of child vocabulary competence included two measures each of spontaneous speech, experimenter assessments, and maternal reports. Maternal measures, from proximal to distal, included vocabulary, verbal intelligence, personality, attitudes toward parenting, knowledge of parenting, and SES. Structural equation modelling supported several direct unique predictive relations: child gender (girls higher) and social competence as well as maternal attitudes toward parenting predicted child vocabulary competence, and mothers' vocabulary predicted child vocabulary comprehension and two measures of mother-reported child vocabulary expression. In addition, children's vocabulary competence was influenced indirectly by mothers' vocabulary, social personality, and knowledge of child development. Maternal vocabulary itself was positively influenced by SES, maternal verbal intelligence, and mothers' knowledge about parenting. Individual variation in child vocabulary competence might best be understood as arising within a nexus of contextual factors both proximal and distal to the child.
SN  - 0305-0009
AD  - Child and Family Research, Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 31 -- Room B2B15, 9000 Rockville Pike, Bethesda, MD 20892-2030, e-mail: Marc_H_Bornstein@nih.gov
U2  - PMID: 9770912.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Martin, Alex A.
T1  - Knowing and Remembering: Here's to You, Lou Costa.
JO  - Journal of Clinical & Experimental Neuropsychology
JF  - Journal of Clinical & Experimental Neuropsychology
Y1  - 1998/06//
VL  - 20
IS  - 3
M3  - Article
SP  - 299
EP  - 301
PB  - Taylor & Francis Ltd
SN  - 13803395
AB  - Profiles neuropsychologist Louis David Costa.  Societies founded by Costa; Career achievements; Contributions to neuropsychology; Academic services rendered by Costa.
KW  - NEUROPSYCHOLOGY
KW  - NEUROSCIENTISTS
KW  - COSTA, Louis
N1  - Accession Number: 4561528; Martin, Alex A. 1; Affiliation:  1: National Institute of Mental Health, Laboratory of Brain and Cognition, USA, Bethesda, MD 20892-1366, 10 Center Drive; Source Info: Jun98, Vol. 20 Issue 3, p299; Subject Term: NEUROPSYCHOLOGY; Subject Term: NEUROSCIENTISTS; People: COSTA, Louis; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
AU  - Stone, Stephanie V.
AU  - Fagan, Peter J.
AU  - Costa Jr., Paul T.
T1  - Identifying Causes of Disagreement Between Self-Reports and Spouse Ratings of Personality.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1998/06//
VL  - 66
IS  - 3
M3  - Article
SP  - 285
EP  - 286
PB  - Wiley-Blackwell
SN  - 00223506
AB  - Self-reports and spouse ratings of personality traits typically show less-than-perfect agreement, but powerful moderators of agreement have not yet been identified. In Study 1, 47 married couples completed the Revised NEO Personality Inventory to describe themselves and their spouses. Extent of agreement was not consistently moderated by response sets; the age, intelligence, or education of the respondent; or the length or quality of the relationship. In Study 2 these couples were interviewed about reasons for substantial disagreements, and an audiotape was content-analyzed. Sixteen reasons were reliably coded, including idiosyncratic understanding of items, reference to different time frames or roles, and unavailability of covert experience to the spouse. Faking good, assumed similarity, and other variables prominent in the psychometric literature were relatively unimportant. Findings (1) suggest that attempts to improve the validity of self-reports and ratings may need to be refocused and (2) underscore the desirability of routinely obtaining multiple sources of information on personality. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MARRIED people
KW  - SELF-evaluation
KW  - NEO Personality Inventory
KW  - PERSONALITY tests
KW  - PSYCHOMETRICS
KW  - LIFE CYCLES: ADULTHOOD, AGING, AND THE FAMILY
N1  - Accession Number: 676326; McCrae, Robert R. 1; Email Address: JEFFM@MVX.GRC.NIA.NIH.GOV Stone, Stephanie V. 1 Fagan, Peter J. 2 Costa Jr., Paul T. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, National Institutes of Health  2: Johns Hopkins Medical Institutions; Source Info: Jun98, Vol. 66 Issue 3, p285; Subject Term: MARRIED people; Subject Term: SELF-evaluation; Subject Term: NEO Personality Inventory; Subject Term: PERSONALITY tests; Subject Term: PSYCHOMETRICS; Author-Supplied Keyword: LIFE CYCLES: ADULTHOOD, AGING, AND THE FAMILY; Number of Pages: 29p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jang, Kerry L.
AU  - Angleitner, Alois
AU  - Riemann, Rainer
AU  - McCrae, Robert R.
AU  - Livesley, W. John
T1  - Heritability of Facet-Level Traits in a Cross-Cultural Twin Sample: Support for a Hierarchical Model of Personality.
JO  - Journal of Personality & Social Psychology
JF  - Journal of Personality & Social Psychology
Y1  - 1998/06//
VL  - 74
IS  - 6
M3  - Article
SP  - 1556
EP  - 1565
SN  - 00223514
AB  - The common variance among personality traits can be summarized in the factors of the five-factor model, which are known to be heritable. This study examined heritability of the residual specific variance in facet-level traits from the Revised NEO Personality Inventory. Analyses of raw and residual facet scales across Canadian (183 monozygotic [MZ] and 175 dizogotic [DZ] pairs) and German (435 MZ and 205 DZ pairs) twin samples showed genetic and environmental influences of the same type and magnitude across the 2 samples for most facets. Additive genetic effects accounted for 25% to 65% of the reliable specific variance. Results provide strong support for hierarchical models of personality that posit a large number of narrow traits in addition to a few broader trait factors or domains. Facet-level traits are not simply exemplars of the broad factors they define; they are discrete constructs with their own heritable and thus biological basis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - NEO Personality Inventory
KW  - PERSONALITY tests
KW  - PSYCHOLOGY
KW  - GENETICS
N1  - Accession Number: 791372; Jang, Kerry L. 1; Email Address: kjang@unixg.ubc.ca Angleitner, Alois 2 Riemann, Rainer 2 McCrae, Robert R. 3 Livesley, W. John 1; Affiliation:  1: University of British Columbia  2: Universität Bielefeld  3: Gerontology Research Center, National Institute on Aging, National Institutes of Health; Source Info: Jun98, Vol. 74 Issue 6, p1556; Subject Term: PERSONALITY; Subject Term: NEO Personality Inventory; Subject Term: PERSONALITY tests; Subject Term: PSYCHOLOGY; Subject Term: GENETICS; Number of Pages: 10p; Illustrations: 7 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kitamura, Toshinori
AU  - Sugawara, Masumi
AU  - Shima, Satoru
AU  - Toda, Mari A.
T1  - Relationship of Order and Number of Siblings to Perceived Parental Attitudes in Childhood.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1998/06//
VL  - 138
IS  - 3
M3  - Article
SP  - 342
EP  - 350
PB  - Taylor & Francis Ltd
SN  - 00224545
AB  - The article examines the effect of the number of siblings on adults' retrospective perceptions of their childhood and their parents' rearing practices. The effects parental attitudes in childhood on the onset of depression, anxiety disorders, and other psychiatric conditions among adults have been extensively studied. Another area of perceived rearing research has been the development of measuring instruments. According to a measure of perceived parental behavior that had been validated among a population with the same cultural background as that of the present sample, the number and sex of siblings, but not the total family size, contributed, although only slightly, to the participants' views of their upbringing. The finding that parental affect was reduced as the number of elder sisters increased is consistent with other retrospective studies in contrast, the finding that parental overprotection was also reduced as the number of younger brothers increased contradicted those of the previous literature. That finding may be attributable to the different instrument used to measure the parental attitudes or to the relatively small number of siblings in this study; however, it may also be attributable to the fact that previous researchers did not subdivide the siblings as researchers did in the present study. Same sex, opposite sex, elder, or younger siblings may be differentially linked to the parental behavior toward the participant.
KW  - BROTHERS & sisters
KW  - STRESS (Psychology)
KW  - PARENT & child
KW  - CHILD rearing
KW  - SIBLING abuse
KW  - FAMILY violence
N1  - Accession Number: 566510; Kitamura, Toshinori 1 Sugawara, Masumi 1 Shima, Satoru 2 Toda, Mari A. 3; Affiliation:  1: Department of Sociocu itu ral Environmental Research National Institute of Mental Health, Japan.  2: Tokyo Keizai University, Japan.  3: Hokkaido University of Education Japan.; Source Info: Jun1998, Vol. 138 Issue 3, p342; Subject Term: BROTHERS & sisters; Subject Term: STRESS (Psychology); Subject Term: PARENT & child; Subject Term: CHILD rearing; Subject Term: SIBLING abuse; Subject Term: FAMILY violence; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3333
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107274835
T1  - Scientific progress in understanding: oral and pharyngeal cancers.
AU  - Winn DM
AU  - Diehl SR
AU  - Horowitz AM
AU  - Gutkind S
AU  - Sandberg AL
AU  - Kleinman DV
Y1  - 1998/06//
N1  - Accession Number: 107274835. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; CEU; directories; exam questions; tables/charts; website. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Mouth Neoplasms -- Etiology
KW  - Pharyngeal Neoplasms -- Etiology
KW  - Cell Physiology
KW  - Mutation
KW  - Genetic Engineering
KW  - Mouth Neoplasms -- Prevention and Control
KW  - Pharyngeal Neoplasms -- Prevention and Control
KW  - Research -- Organizations -- United States
KW  - United States
KW  - Education, Continuing (Credit)
SP  - 713
EP  - 771
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 129
IS  - 6
CY  - Chicago, Illinois
PB  - American Dental Association
AB  - Oral and pharyngeal cancers result from a complex interaction between genetic susceptibility and behavioral factors. Improved understanding of the underlying genetic events has led to insights about how oral and pharyngeal cancers develop and suggests promising new treatments. Tobacco and alcohol consumption are associated with most oral and pharyngeal cancers. Dental professionals' efforts to modify their patients' tobacco and alcohol use and to detect oral lesions at an early stage, together with scientific advances, will help reduce the impact of these cancers.
SN  - 0002-8177
AD  - Division of Intramural Research, National Institute of Dental Research, National Institutes of Health, Natcher Building, Room 4AS-19F, 45 Center Drive, Bethesda, MD 20892-6401
U2  - PMID: 9631611.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107274835&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107274847
T1  - Sjogren's syndrome: a model for dental care in the 21st century.
AU  - Fox PC
AU  - Brennan M
AU  - Pillemer S
AU  - Radfar L
AU  - Yamano S
AU  - Baum BJ
Y1  - 1998/06//
N1  - Accession Number: 107274847. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Sjogren's Syndrome -- Diagnosis
KW  - Sjogren's Syndrome -- Therapy
KW  - Dental Care for Chronically Ill
KW  - Saliva -- Physiology
KW  - Sjogren's Syndrome -- Symptoms
KW  - Sjogren's Syndrome -- Complications
KW  - Salivary Glands -- Radiography
KW  - Education, Continuing (Credit)
SP  - 719
EP  - 771
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 129
IS  - 6
CY  - Chicago, Illinois
PB  - American Dental Association
AB  - The diagnosis and treatment of Sjogren's syndrome, which poses many severe complications, should be of critical interest to dentists, who are often the first practitioners to detect symptoms. Dentistry is an integral part of health care delivery for patients with this condition. Management of Sjogren's syndrome can be seen as a model for the expanded scope of dental care in the future.
SN  - 0002-8177
AD  - Gene Therapy and Therapeutics Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 9631612.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Li, Qian
AU  - Luyo, Debara
AU  - Matteson, Dawn M.
AU  - Chan, Chi-Chao
AU  - Li, Q
AU  - Luyo, D
AU  - Matteson, D M
AU  - Chan, C C
T1  - Suppressive effect of antiflammin-2 on compound 48/80-induced conjunctivitis. Role of phospholipase A2s and inducible nitric oxide synthase.
JO  - Ocular Immunology & Inflammation
JF  - Ocular Immunology & Inflammation
Y1  - 1998/06//
VL  - 6
IS  - 2
M3  - journal article
SP  - 65
EP  - 73
PB  - Taylor & Francis Ltd
SN  - 09273948
AB  - Phospholipase A2s (PLA2s) are a family of esterases that initiate the arachidonic acid cascade, which results in the production of numerous inflammatory mediators. We investigated the expression of Group I and II PLA2 proteins and Group II mRNA in normal conjunctivae and in the conjunctivae of mice with compound 48/80-induced conjunctivitis. Conjunctivitis was induced in C57BL/6 mice by topical instillation of compound 48/80 (C48/80). Mice were then treated with corticosteroid (Pred Forte), antiflammin-2 (AF2, a synthetic peptide that inhibits PLA2), or a placebo (Dacriose, an isotonic, buffered, sterile eye irrigating solution). Low levels of PLA2s were detected on the epithelium of normal conjunctivae. One hr after C48/80 instillation, the expression of PLA2s appeared and increased in the substantia propria, peaked at 6 hr, and returned to baseline 72 hr later. Compared to the placebo, the conjunctivitis was moderate in the AF2-treated group and mild in Pred Forte-treated group. The expression of PLA2s was suppressed in mice treated with Pred Forte and AF2. iNOS mRNA was also diminished in the AF2- and Pred Forte-treated groups. The mechanisms by which anti-allergic medications suppress conjunctivitis may involve the inhibition of PLA2s and iNOS. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Ocular Immunology & Inflammation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONJUNCTIVITIS -- Treatment
KW  - PHOSPHOLIPASES
KW  - EYE -- Diseases -- Treatment
KW  - RNA metabolism
KW  - ALLERGIC conjunctivitis
KW  - PREVENTION
KW  - AMINES
KW  - ANIMALS
KW  - ANTI-inflammatory agents
KW  - CONJUNCTIVA
KW  - DNA probes
KW  - ESTERASES
KW  - GLUCOCORTICOIDS
KW  - IMMUNOENZYME technique
KW  - IN situ hybridization
KW  - MICE
KW  - NONSTEROIDAL anti-inflammatory agents
KW  - OLIGOPEPTIDES
KW  - OPHTHALMIC drugs
KW  - OXIDOREDUCTASES
KW  - PEPTIDES
KW  - CUTANEOUS therapeutics
KW  - PREDNISOLONE
KW  - DRUGS -- Physiological effect
N1  - Accession Number: 5306484; Li, Qian Luyo, Debara Matteson, Dawn M. Chan, Chi-Chao Li, Q 1 Luyo, D Matteson, D M Chan, C C; Affiliation:  1: Section on Immunopathology, National Eye Institute, National Institute of Health, Bethesda, MD, USA; Source Info: Jun98, Vol. 6 Issue 2, p65; Subject Term: CONJUNCTIVITIS -- Treatment; Subject Term: PHOSPHOLIPASES; Subject Term: EYE -- Diseases -- Treatment; Subject Term: RNA metabolism; Subject Term: ALLERGIC conjunctivitis; Subject Term: PREVENTION; Subject Term: AMINES; Subject Term: ANIMALS; Subject Term: ANTI-inflammatory agents; Subject Term: CONJUNCTIVA; Subject Term: DNA probes; Subject Term: ESTERASES; Subject Term: GLUCOCORTICOIDS; Subject Term: IMMUNOENZYME technique; Subject Term: IN situ hybridization; Subject Term: MICE; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: OLIGOPEPTIDES; Subject Term: OPHTHALMIC drugs; Subject Term: OXIDOREDUCTASES; Subject Term: PEPTIDES; Subject Term: CUTANEOUS therapeutics; Subject Term: PREDNISOLONE; Subject Term: DRUGS -- Physiological effect; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: journal article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5306484&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107169554
T1  - Contextual determinants of maternal mortality in rural Pakistan.
AU  - Midhet F
AU  - Becker S
AU  - Berendes HW
Y1  - 1998/06//
N1  - Accession Number: 107169554. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. Grant Information: NICHD and UNICEF. NLM UID: 8303205. 
KW  - Maternal Mortality -- Pakistan
KW  - Social Environment
KW  - Pakistan
KW  - Funding Source
KW  - Rural Areas
KW  - Retrospective Design
KW  - Interviews
KW  - Cluster Sample
KW  - Health Services Accessibility
KW  - Confidence Intervals
KW  - Independent Variable
KW  - Odds Ratio
KW  - Conceptual Framework
KW  - Logistic Regression
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Pregnancy
KW  - Female
KW  - Human
SP  - 1587
EP  - 1598
JO  - Social Science & Medicine
JF  - Social Science & Medicine
JA  - SOC SCI MED
VL  - 46
IS  - 12
PB  - Pergamon Press - An Imprint of Elsevier Science
AB  - Maternal mortality is high in Pakistan, particularly in the rural areas which have poor access to health services. We investigated the risk factors associated with maternal mortality in sixteen rural districts of Balochistan and the North-West Frontier (NWFP) provinces of Pakistan. We designed a nested case-control study comprising 261 cases (maternal deaths reported during last five years) and 9135 controls (women who survived a pregnancy during last five years). Using contextual analysis, we estimated the interactions between the biological risk factors of maternal mortality and the district-level indicators of health services. Women under 19 or over 39 yr of age, those having their first birth, and those having a previous history of fetal loss were at greater risk of maternal death. Staffing patterns of peripheral health facilities in the district and accessibility of essential obstetric care (EOC) were significantly associated with maternal mortality. These indicators also modified the effects of the biological risk factors of maternal mortality. For example, nulliparous women living in the under-served districts were at greater risk than those living in the better-served districts. Our results are consistent with several studies which have pointed out the role of health services in the causation of maternal mortality. Many such studies have implicated distance to hospital (an indicator of access to EOC) and lack of prenatal care as major determinants of maternal mortality. We conclude that better staffing of peripheral health facilities and improved access to EOC could reduce the risk of maternal mortality among women in rural Balochistan and the NWFP.
SN  - 0277-9536
AD  - National Institute of Child Health and Human Development, 6100 Executive Blvd., Room 7B05, Bethesda, MD 20892
U2  - PMID: 9672397.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107169554&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2010-06178-007
AN  - 2010-06178-007
AU  - Bornstein, Marc H.
AU  - Haynes, Maurice O.
AU  - Painter, Kathleen M.
T1  - Sources of child vocabulary competence: A multivariate model.
JF  - Journal of Child Language
JO  - Journal of Child Language
JA  - J Child Lang
Y1  - 1998/06//
VL  - 25
IS  - 2
SP  - 367
EP  - 393
CY  - United Kingdom
PB  - Cambridge University Press
SN  - 0305-0009
SN  - 1469-7602
AD  - Bornstein, Marc H., Child and Family Research, Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, National Institutes of Health, Building 31 - Room B2B15, 9000 Rockville Pike, Bethesda, MD, US, 20892-2030
N1  - Accession Number: 2010-06178-007. PMID: 9770912 Partial author list: First Author & Affiliation: Bornstein, Marc H.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20100412. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Language Development; Mother Child Relations; Social Skills; Vocabulary. Minor Descriptor: Competence; Human Sex Differences; Individual Differences; Mothers; Sociocultural Factors. Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adulthood (18 yrs & older) (300). Tests & Measures: Early Language Inventory; Vineland Adaptive Behavior Scales —Interview Edition, Survey Form; The Peabody Picture Vocabulary Test —Revised; Self-Perceptions of the Parental Role; Parental Style Questionnaire; Knowledge of Infant Development Inventory; Social Desirability Scale; Reynell Developmental Language Scales-Second Revision, Expressive Language Scale; Verbal Comprehension Scale 'A'; Jackson Personality Inventory. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 27. Issue Publication Date: Jun, 1998. Publication History: Revised Date: Nov 3, 1997; First Submitted Date: Mar 27, 1993. Copyright Statement: Cambridge University Press. 1998. 
AB  - This study examines sources of individual variation in child vocabulary competence in the context of a multivariate developmental ecological model. Maternal sociodemographic characteristics, personological characteristics, and vocabulary, as well as child gender, social competence, and vocabulary competence were evaluated simultaneously in 126 children aged 1;8 and their mothers. Measures of child vocabulary competence included two measures each of spontaneous speech, experimenter assessments, and maternal reports. Maternal measures, from proximal to distal, included vocabulary, verbal intelligence, personality, attitudes toward parenting, knowledge of parenting, and SES. Structural equation modelling supported several direct unique predictive relations: child gender (girls higher) and social competence as well as maternal attitudes toward parenting predicted child vocabulary competence, and mothers' vocabulary predicted child vocabulary comprehension and two measures of mother-reported child vocabulary expression. In addition, children's vocabulary competence was influenced indirectly by mothers' vocabulary, social personality, and knowledge of child development. Maternal vocabulary itself was positively influenced by SES, maternal verbal intelligence, and mothers' knowledge about parenting. Individual variation in child vocabulary competence might best be understood as arising within a nexus of contextual factors both proximal and distal to the child. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - child vocabulary competence
KW  - individual variation
KW  - multivariate developmental ecological model
KW  - maternal sociodemographic characteristics
KW  - child gender
KW  - social competence
KW  - 1998
KW  - Language Development
KW  - Mother Child Relations
KW  - Social Skills
KW  - Vocabulary
KW  - Competence
KW  - Human Sex Differences
KW  - Individual Differences
KW  - Mothers
KW  - Sociocultural Factors
KW  - 1998
DO  - 10.1017/S0305000998003456
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-06178-007&site=ehost-live&scope=site
UR  - Marc_H_Bornstein@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13477-026
AN  - 2008-13477-026
AU  - Okabe, Shigeo
AU  - Vicario-Abejón, Carlos
AU  - Segal, Menahem
AU  - McKay, Ronald D. G.
T1  - Survival and synaptogenesis of hippocampal neurons without NMDA receptor function in culture.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/06//
VL  - 10
IS  - 6
SP  - 2192
EP  - 2198
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Okabe, Shigeo, National Institute of Bioscience and Human-Technology, 1-1, Higashi, Tsukuba, Ibaraki, Japan, 305
N1  - Accession Number: 2008-13477-026. PMID: 9753105 Partial author list: First Author & Affiliation: Okabe, Shigeo; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel. Other Publishers: Blackwell Publishing. Release Date: 20090105. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dendrites; Hippocampus; N-Methyl-D-Aspartate; Neurons; Synapses. Minor Descriptor: Cells (Biology); Mice. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 1998. 
AB  - Physiological and morphological properties of cultured hippocampal neurons were measured to investigate whether NMDA receptors play a role in survival and differentiation. Neurons dissociated from mouse embryos with different NMDAR1 genotypes were grown in culture. Electrophysiological analysis verified the absence of NMDA receptor-mediated currents in neurons taken from homozygous mutant (NR1-/-) embryos. The number of surviving hippocampal neurons was 2.5-fold higher in cultures from the NR1-/- embryos compared with wild type (NR1+/+) and heterozygous (NR1+/-) controls. Despite the lack of NMDA receptor function, NR1-/- neurons formed synapsin I-positive presynaptic boutons associated with MAP2ab-positive dendrites in culture. Confocal microscopic analysis of Dil labelled neurons confirmed the presence of dendritic spines on NR1-/- neurons with 80% of the density found in NR1+/+ neurons. These results suggest that the NMDA receptor has little effect on general features of neuronal differentiation. In contrast, there is clear effect on neuronal survival. This finding establishes neuron number in standard culture conditions as a measure of NMDA receptor activity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - survival
KW  - synaptogenesis
KW  - hippocampal neurons
KW  - NMDA receptor function
KW  - cell culture
KW  - dendritic spine
KW  - knockout mice
KW  - synapse formation
KW  - 1998
KW  - Dendrites
KW  - Hippocampus
KW  - N-Methyl-D-Aspartate
KW  - Neurons
KW  - Synapses
KW  - Cells (Biology)
KW  - Mice
KW  - 1998
DO  - 10.1046/j.1460-9568.1998.00233.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13477-026&site=ehost-live&scope=site
UR  - sokabe@nibh.go.jp
DP  - EBSCOhost
DB  - psyh
ER  - 
TY  - JOUR
ID  - 2015-40563-003
AN  - 2015-40563-003
AU  - Veeranna
AU  - Amin, Niranjana D.
AU  - Ahn, Natalie G.
AU  - Jaffe, Howard
AU  - Winters, Christine A.
AU  - Grant, Philip
AU  - Pant, Harish C.
T1  - Mitogen-activated protein kinases (Erk1,2) phosphorylate lys-ser-pro (KSP) repeats in neurofilament proteins NF-H and NF-M.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/06//
VL  - 18
IS  - 11
SP  - 4008
EP  - 4021
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Pant, Harish C., Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 4D20, 9000 Rockville Pike, Bethesda, MD, US, 20892-4130
N1  - Accession Number: 2015-40563-003. PMID: 9592082 Partial author list: First Author & Affiliation: Veeranna; Laboratorie of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Axons; Neuroprotection; Mitogen Activated Protein Kinase; Phosphorylation; Cytoskeleton. Minor Descriptor: Proteins; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Jun, 1998. Publication History: Accepted Date: Mar 10, 1998; Revised Date: Mar 6, 1998; First Submitted Date: Jan 27, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Mammalian neurofilament proteins, particularly midsized (NF-M) and heavy (NF-H) molecular weight neurofilament proteins, are highly phosphorylated in axons. Neurofilament function depends on the state of phosphorylation of the numerous serine/threonine residues in these proteins. Most phosphorylation occurs in the lys-ser-pro (KSP) repeats in the C-terminal tail domains of NF-H and NF-M. In our previous study, cyclindependent kinase 5 (cdk5) was shown to phosphorylate specifically the KSPXK repeats in rat NF-H. Because 80% of the repeats are of the KSPXXXK type, it was of interest to determine which kinase phosphorylates these motifs. Using a synthetic KSPXXXK peptide to screen for a specific kinase, we fractionated rat brain extracts by column chromatography and identified extracellular signal-regulated kinase (Erk2) activated by an upstream activator, the mitogen-activated protein kinase kinase MAPKK (MEK), by Western blot analysis, sequence identification, and inhibition by a specific MEK inhibitor (PD 98059). The fraction containing Erk2, as well as bacterially expressed Erk1 and Erk2, phosphorylated all types of KSP motifs in peptides (KSPXK, KSPXXK, KSPXXXK, and KSPXXXXK) derived from NF-M and NF-H. They also phosphorylated an expressed 24 KSPXXXK repeat NF-H polypeptide, an expressed NF-H as well as dephosphorylated native rat NF-H, and NF-M proteins with accompanying decreases in their respective electrophoretic mobilities. A comparative kinetic study of Erk2 and cdk5 phosphorylation of KSPXK and KSPXXXK peptides revealed that, in contrast to cdk5, which phosphorylated only the KSPXK peptide, Erk2 could phosphorylate both. The preferred substrate for Erk2 was KSPXXXK peptide. The MEK inhibitor PD 98059 also inhibited phosphorylation of NF-H, NF-M, and microtubuleassociated protein (MAP) in primary rat hippocampal cells and caused a decrease in neurite outgrowth, suggesting that Erk1,2 may play an important role in neurite growth and branching. These data suggest that neuronal Erk1 and Erk2 are capable of phosphorylating serine residues in diverse KSP repeat motifs in NF-M and NF-H. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - MAPK
KW  - neurofilaments
KW  - cytoskeleton
KW  - phosphorylation
KW  - neuron
KW  - rat
KW  - 1998
KW  - Axons
KW  - Neuroprotection
KW  - Mitogen Activated Protein Kinase
KW  - Phosphorylation
KW  - Cytoskeleton
KW  - Proteins
KW  - Rats
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40563-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-40563-034
AN  - 2015-40563-034
AU  - Bac, Pierre
AU  - Maurois, Pierre
AU  - Dupont, Charlotte
AU  - Pages, Nicole
AU  - Stables, James P.
AU  - Gressens, Pierre
AU  - Evrard, Philippe
AU  - Vamecq, Joseph
T1  - Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: A nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/06//
VL  - 18
IS  - 11
SP  - 4363
EP  - 4373
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Vamecq, Joseph, Institut National de la Sante et de la Recherche Medicale, Domaine du Centre d’Etude et de Recherche Technologique des Industries Alimentaires, 369, Rue Jules Guesde, BP 39, F-59651, Villeneuve d’Ascq, France, Cedex
N1  - Accession Number: 2015-40563-034. PMID: 9592113 Partial author list: First Author & Affiliation: Bac, Pierre; Laboratoire de Pharmacologie, Faculte de Pharmacie, Chatenay-Malabry, France. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Anticonvulsive Drugs; Audiogenic Seizures; Magnesium; Neuroprotection. Minor Descriptor: Animal Models; Mice; Screening; White Matter. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jun, 1998. Publication History: Accepted Date: Mar 17, 1998; First Submitted Date: Feb 13, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - A great many animal models for audiogenic seizures have been described. The extent to which these models may provide insight into neuroscience fields such as abnormal locomotor behavior (wild running), seizures and anticonvulsants, and neuroinsults and neuroprotectors is examined here by our study of magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice. MDDASs were induced in all of the eight tested adult murine strains and are presented as a sequence of four successive components (latency, wild running, convulsion, and recovery phase periods). Compared with several classic seizure tests, the nutritional MDDAS model responded to low doses of prototype antiepileptic drugs (AEDs), including phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), valproic acid (VPA), ethosuximide (ESM), and diazepam (DZP). Modulation by AEDs of the four components of MDDAS indicated that this seizure test was discriminatory, distinguishing between phenytoinergic (PHT, CBZ), GABAergic (PB, VPA, DZP), and ethosuximide (ESM) compounds. Suitability of the MDDAS test for evaluation of neuroprotective compounds was also examined: it showed partial (melatonin) and complete (WEB2170, an anti-PAF agent) reduction of recovery phase by non-anticonvulsant doses of test compounds. These neuroprotective responses were compared with neuroprotective potentials determined in a model of neonatal cerebral injury induced by focal injection of ibotenate (a glutamate analog). WEB2170 and melatonin reduced the size of lesions in white matter, but only WEB2170 protected cortical plate against ibotenate-induced lesions. In addition to the original neuroprotective behavior of WEB2170, studies on the neuroprotectors also supported GABAergic anticonvulsant activity of melatonin in the MDDAS test. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - antiepileptic drugs
KW  - phenytoin
KW  - carbamazepine
KW  - phenobarbital
KW  - ethosuximide
KW  - valproic acid
KW  - diazepam
KW  - nutrition
KW  - magnesium deficiency
KW  - anticonvulsants
KW  - audiogenic seizures
KW  - electroshock
KW  - MES
KW  - pentylenetetrazol
KW  - bicuculline
KW  - neuroprotectors
KW  - picrotoxin
KW  - thieno-triazolodiazepine
KW  - benzodiazepine
KW  - hetrazepine
KW  - melatonin
KW  - ibotenate
KW  - PAF
KW  - anti-PAF
KW  - WEB2170
KW  - GABA
KW  - NMDA receptor
KW  - discriminatory screening
KW  - seizure test
KW  - 1998
KW  - Anticonvulsive Drugs
KW  - Audiogenic Seizures
KW  - Magnesium
KW  - Neuroprotection
KW  - Animal Models
KW  - Mice
KW  - Screening
KW  - White Matter
KW  - 1998
U1  - Sponsor: University of Lille II, University Hospital of Lille, Faculty of Medicine, France. Other Details: Comité Directeur de la Recherche. Recipients: No recipient indicated
U1  - Sponsor: Institut National de la Santé et de la Recherche Médicale, France. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-40563-034&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Ory, Marcia G.
AU  - Cooper, James
AU  - Siu, Albert L.
AD  - National Institute on Aging
AD  - Agency for Health Care Policy & Research
AD  - Mt Sinai Medical Center, New york
T1  - Toward the Development of a Research Agenda on Organizational issues in the Delivery of Healthcare to Older Americans
JO  - Health Services Research
JF  - Health Services Research
Y1  - 1998/06/02/
VL  - 33
IS  - 2
SP  - 287
EP  - 297
SN  - 00179124
N1  - Accession Number: 0473957; Keywords: Health Care;  Healthcare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199810
KW  - Analysis of Health Care Markets          I11
KW  - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination          J14
L3  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0473957&site=ehost-live&scope=site
UR  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 107225682
T1  - HIV prevention with drug-using populations -- current status and future prospects: introduction and overview.
AU  - Needle RH
AU  - Coyle SL
AU  - Normand J
AU  - Lambert E
AU  - Cesari H
Y1  - 1998/06/02/1998 Jun Suppl 1
N1  - Accession Number: 107225682. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; editorial; tables/charts. Supplement Title: 1998 Jun Suppl 1. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - HIV Infections -- Prevention and Control
KW  - Substance Abuse -- Prevention and Control
KW  - Public Health
KW  - Community Programs
KW  - Needle Exchange Programs
KW  - Drug Rehabilitation Programs
KW  - Community Networks
SP  - 4
EP  - 18
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 113
PB  - Sage Publications Inc.
SN  - 0033-3549
AD  - National Institute on Drug Abuse, Division of Epidemiology and Prevention Research, Parklawn Building, Room 9A-42, 5600 Fishers Lane, Rockville, MD 20857; email rn28E@nih.gov
U2  - PMID: 9750106.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107225682&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107225691
T1  - Outreach-based HIV prevention for injecting drug users: a review of published outcome data.
AU  - Coyle SL
AU  - Needle RH
AU  - Normand J
Y1  - 1998/06/02/1998 Jun Suppl 1
N1  - Accession Number: 107225691. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; research; review; tables/charts. Supplement Title: 1998 Jun Suppl 1. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - HIV Infections -- Prevention and Control
KW  - Substance Abuse, Intravenous
KW  - Community Programs
KW  - Outcomes (Health Care)
KW  - Literature Review
KW  - Outcomes Research
KW  - Evaluation Research
KW  - Causal Attribution
KW  - Behavioral Changes
KW  - Risk Taking Behavior -- Prevention and Control
KW  - Observational Methods
KW  - Human
SP  - 19
EP  - 30
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 113
PB  - Sage Publications Inc.
AB  - Objectives. Over the past decade, a body of observational research has accrued about the effects of outreach-based human immunodeficiency virus (HIV) interventions for drug users. The authors reviewed the findings related to postintervention behavior changes and integrated findings across studies to provide the best estimate of program impact. Methods. The authors conducted a computerized literature search to locate published accounts of HIV intervention effects on drug users. Thirty-six publications covered outreach-based HIV risk reduction interventions for out-of-treatment injecting drug users (IDUs) and reported intervention effects on HIV-related behaviors or HIV seroincidence. Two-thirds of the publications reported that participation in street-based outreach interventions was followed with office-based HIV testing and counseling. The authors described the theoretical underpinnings of outreach intervention components, the content of the interventions, and the outcome measures that investigators used most frequently. The authors also described and critiqued the evaluation study designs that were in place. Because most of the evaluations were based on pretest and posttest measures of behavior rather than on controlled studies, results were examined with respect to accepted criteria for attributing intervention causality, that is, the plausibility of cause and effect, correct temporal sequence, consistency of findings across reports, strength of associations observed, specificity of associations, and close response relationships between interventions and observed outcomes. Results. The majority of the published evaluations showed that IDUs in a variety of places and time periods changed their baseline drug-related and sex-related risk behaviors following their participation in an outreach-based HIV risk reduction intervention. More specifically, the publications indicated that IDUs regularly reported significant follow-up reductions in drug injection, multiperson reuse of syringes and needles, multiperson reuse of other injection equipment (cookers, cotton, rinse water), and crack use. The studies also showed significant intervention effects in promoting entry into drug treatment and increasing needle disinfection. Although drug users also significantly reduced sex-related risks and increased condom use, the majority still practiced unsafe sex. One quasiexperimental study found that reductions in injection risks led to significantly reduced HIV seroincidence among outreach participants. Few investigators looked at dosage effects, but two reports suggested that the longer the exposure to outreach-based interventions, the greater the reductions in drug injection frequency. Conclusions. Accumulated evidence from observational and quasi-experimental studies strongly indicate that outreach-based interventions have been effective in reaching out-of-treatment IDUs, providing the means for behavior change and inducing behavior change in the desired direction. The findings provide sound evidence that participation in outreach-based prevention programs can lead to lower HIV incidence rates among program participants.
SN  - 0033-3549
AD  - National Institute on Drug Abuse, Office of Extramural Program Review, Parklawn Building, Room 10-42, 5600 Fishers Lane, Rockville, MD 20857; email sc91m@nih.gov
U2  - PMID: 9722807.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107225691&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107225892
T1  - What we have learned from research about the prevention of HIV transmission among drug abusers.
AU  - Sloboda Z
Y1  - 1998/06/02/1998 Jun Suppl 1
N1  - Accession Number: 107225892. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Supplement Title: 1998 Jun Suppl 1. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - HIV Infections -- Prevention and Control
KW  - Substance Abuse, Intravenous
KW  - Health Promotion -- Methods
KW  - Experimental Studies -- Evaluation
KW  - Risk Taking Behavior -- Prevention and Control
KW  - Community Networks
KW  - Research Methodology
SP  - 194
EP  - 204
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 113
PB  - Sage Publications Inc.
AB  - Objective. After more than 10 years of experience conducting behavioral change interventions and with accumulated research results, several emergent principles have been identified for the effective prevention of HIV transmission among drug abusers. In August 1997, a symposium was held in Flagstaff, Arizona, to achieve two major purposes: (1) to synthesize the findings from HIV prevention research conducted to date for interventions targeting drug abusers and (2) to extract a preliminary set of prevention principles that could be linked to effectiveness across at least two or more studies. This chapter summarizes the key findings of that symposium. Methods. Major findings were abstracted from the conclusion sections of the presentations and from the chapters included in this special volume. Many consistencies regarding intervention approaches across studies were noted. These findings are discussed under the following headings: General Observations, Engagement, Multiple Interventions, Intervention Issues, Methodological Issues, and Translation from Research to Practice. Suggested areas for further research are also presented and discussed. Results. Ten principles that have implications for HIV prevention interventions emerged from this preliminary review of the research. These principles engage drug users into the intervention; specify target behaviors and attitudes for intervention; suggest settings to optimize outreach; and recommend booster approaches to reinforce knowledge, skills, and attitudes learned through the intervention. Conclusions. The drug abuse community is threatened by the incursion of HIV and by the hepatitis viruses A, B, and C. The same behaviors are involved in transmitting all of these viruses. The first generation of research to assess the impact of a variety of interventions delivered among drug abusers to prevent HIV has shown consistently favorable findings, proving that drug abusers can be helped to change their risky drug-using behaviors and, to a lesser extent, their risky sexual behaviors. The need to translate these findings for community practitioners is heightened by the devastating impact of HIV and AIDS.
SN  - 0033-3549
AD  - National Institute on Drug Abuse, Division of Epidemiology and Prevention Research, Parklawn Building, Room 9A-53, 5600 Fishers Lane, Rockville, MD 20857; email nz6n@nih.gov
U2  - PMID: 9722825.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107225892&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107268861
T1  - Depressive symptoms and physical decline in community-dwelling older persons.
AU  - Penninx BWJ
AU  - Guralnik JM
AU  - Ferrucci L
AU  - Simonsick EM
AU  - Deeg DJH
AU  - Wallace RB
AU  - Penninx, B W
AU  - Guralnik, J M
AU  - Ferrucci, L
AU  - Simonsick, E M
AU  - Deeg, D J
AU  - Wallace, R B
Y1  - 1998/06/03/
N1  - Accession Number: 107268861. Language: English. Entry Date: 19980701. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D); Rosow-Breslau scale. Grant Information: N01-AG-0215/AG/NIA NIH HHS/United States. NLM UID: 7501160. 
KW  - Depression -- In Old Age
KW  - Physical Mobility -- In Old Age
KW  - Movement -- In Old Age
KW  - Funding Source
KW  - Prospective Studies
KW  - Interviews
KW  - Functional Assessment
KW  - Spearman's Rank Correlation Coefficient
KW  - Linear Regression
KW  - Confidence Intervals
KW  - Odds Ratio
KW  - Multivariate Analysis
KW  - Self Report
KW  - Activities of Daily Living
KW  - Aged
KW  - Aged, 80 and Over
KW  - Research Instruments
KW  - Center for Epidemiological Studies Depression Scale
KW  - Human
SP  - 1720
EP  - 1726
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 279
IS  - 21
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Significant symptoms of depression are common in the older community-dwelling population. Although depressive symptoms and disability may commonly occur in the same person, whether depressive symptoms contribute to subsequent functional decline has not been elucidated.Objective: To determine whether depressive symptoms in older persons increase the risk of subsequent decline in physical function as measured by objective performance-based tests.Design: A 4-year prospective cohort study.Setting: The communities of Iowa and Washington counties, Iowa.Participants: A total of 1286 persons aged 71 years and older who completed a short battery of physical performance tests in 1988 and again 4 years later.Main Outcome Measures: Baseline depressive symptoms were assessed by the Center for Epidemiological Studies Depression Scale. Physical performance tests included an assessment of standing balance, a timed 2.4-m (8-ft) walk, and a timed test of 5 repetitions of rising from a chair and sitting down.Results: After adjustment for baseline performance score, health status, and sociodemographic factors, increasing levels of depressive symptoms were predictive of greater decline in physical performance over 4 years (odds ratio for decline in those with depressed mood vs those without, 1.55; 95% confidence interval [CI], 1.02-2.34). Even among those at the high end of the functional spectrum, who reported no disability, the severity of depressive symptoms predicted subsequent decline in physical performance (odds ratio for decline, 1.03; 95% CI, 1.00-1.08).Conclusions: This study provides evidence that older persons who report depressive symptoms are at higher risk of subsequent physical decline. These results suggest that prevention or reduction of depressed mood could play a role in reducing functional decline in older persons.
SN  - 0098-7484
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892-9205, USA
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Md
U2  - PMID: 9624025.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107268861&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107278212
T1  - Trends and outcomes of outpatient mastectomy in elderly women.
AU  - Warren JL
AU  - Riley GF
AU  - Potosky AL
AU  - Klabunde CN
AU  - Richter E
AU  - Ballard-Barbash R
Y1  - 1998/06/03/
N1  - Accession Number: 107278212. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Ambulatory Surgery
KW  - Mastectomy -- Trends
KW  - Breast Neoplasms -- Surgery
KW  - Ambulatory Surgery -- Trends
KW  - Length of Stay
KW  - Medicare
KW  - Readmission
KW  - Treatment Outcomes
KW  - Retrospective Design
KW  - Logistic Regression
KW  - Confidence Intervals
KW  - Aged
KW  - Female
KW  - Human
SP  - 833
EP  - 840
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 90
IS  - 11
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, Executive Plaza North, Rm. 313, Bethesda, MD 20892-7344
U2  - PMID: 9625171.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107278212&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Stevens, Sally J.
AU  - Tortu, Stephanie
AU  - Coyle, Susan L.
T1  - Women Drug Users and HIV Prevention: Overview of Findings and Research Needs.
JO  - Women & Health
JF  - Women & Health
Y1  - 1998/06/06/
VL  - 27
IS  - 1/2
M3  - Article
SP  - 19
EP  - 23
SN  - 03630242
AB  - The article discusses various findings on women drug users and HIV prevention. It highlights a study conducted by Singer and colleagues which found that women who perceived themselves to be at low risk actually engaged in greater HIV risk behavior. Another study showed that HIV risks of women differ depending on the size and type of city in which they live.
N1  - Accession Number: 75291975; Stevens, Sally J. 1 Tortu, Stephanie 2 Coyle, Susan L. 3; Affiliation:  1: Southwest Institute for Research on Women, University of Arizona, Tucson, AZ  2: National Development and Research Institutes, Inc., NY  3: Community Research Branch, National Institute on Drug Abuse, Washington, DC; Source Info: Jun1998, Vol. 27 Issue 1/2, p19; Number of Pages: 5p; Document Type: Article
L3  - 10.1300/J013v27n01_02
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=75291975&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 105846565
T1  - Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease. Part 1: rheumatologic and renal diseases.
AU  - Langford CA
AU  - Klippel JH
AU  - Balow JE
AU  - James SP
AU  - Sneller MC
Y1  - 1998/06/15/06/15/98 Part 1 of 2
N1  - Accession Number: 105846565. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 06/15/98 Part 1 of 2. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Autoimmune Diseases -- Drug Therapy
KW  - Cyclosporine -- Therapeutic Use
KW  - Immunosuppressive Agents -- Therapeutic Use
KW  - Kidney Diseases -- Drug Therapy
KW  - Rheumatic Diseases -- Drug Therapy
KW  - Cell Physiology -- Drug Effects
KW  - Cyclosporine -- Adverse Effects
KW  - Drug Therapy, Combination
KW  - Immunosuppressive Agents -- Adverse Effects
KW  - United States
SP  - 1021
EP  - 1028
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 128
IS  - 12
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
AB  - When cytotoxic agents were initially introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic disease. During the course of this use, however, it became apparent that these agents also suppress the immune system. This usually unwelcome effect was subsequently studied and beneficially directed toward the treatment of non-neoplastic diseases in which autoimmune mechanisms were considered important to pathogenesis. As a result of these investigations, cytotoxic agents and, more recently, cyclosporine have emerged to become an important part of the therapeutic regimen for many autoimmune diseases. Nonetheless, these medications may still cause treatment-induced illness or even death. It is therefore particularly important to weigh the benefits and risks of cytotoxic therapy when treating a non-neoplastic disease. This two-part Clinical Staff Conference reviews data on the efficacy and toxicity of cytotoxic drugs and cyclosporine in selected autoimmune diseases. Part 1 examines the manner in which these agents have been used to treat rheumatologic and renal diseases.
SN  - 0003-4819
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 9625665.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105846565&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107268877
T1  - Trends in HIV incidence among young adults in the United States.
AU  - Rosenberg PS
AU  - Biggar RJ
AU  - Rosenberg, P S
AU  - Biggar, R J
Y1  - 1998/06/17/
N1  - Accession Number: 107268877. Language: English. Entry Date: 19980701. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: National Institutes of Health Cooperative Agreements U01-AI-35039 through U01-AI-35043 and DA10184-01. NLM UID: 7501160. 
KW  - HIV Infections -- Epidemiology -- In Adulthood
KW  - HIV Infections -- Trends -- In Adulthood
KW  - Incidence
KW  - Adult
KW  - Centers for Disease Control and Prevention (U.S.)
KW  - Disease Surveillance
KW  - Data Collection
KW  - Prevalence
KW  - Ethnic Groups
KW  - Male
KW  - Female
KW  - Gay Men
KW  - Heterosexuality
KW  - HIV Infections -- Transmission
KW  - Intravenous Drug Users
KW  - Prospective Studies
KW  - Epidemiological Research
KW  - Funding Source
KW  - Human
SP  - 1894
EP  - 1899
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 279
IS  - 23
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Behaviors that result in potential exposure to human immunodeficiency virus (HIV) usually begin in adolescence or young adulthood, but trends in HIV incidence in young people remain unclear.Objective: To estimate trends in HIV incidence in teenagers and young adults.Design and Setting: Back-calculation of past HIV incidence in persons born between 1960 and 1974 using US national acquired immunodeficiency syndrome (AIDS) incidence data and estimates of the distribution of times between HIV infection and AIDS.Main Outcome Measures: Incidence and prevalence of HIV in 1988 and 1993 in persons aged 20 and 25 years, respectively, in each of those years.Results: As of January 1993, about 22000 men and 11000 women aged 18 to 22 years were living with HIV infection in the United States. Homosexual contact was the leading route of infection among young men. Heterosexual contact was the leading route of infection among young women. The HIV incidence attributed to homosexual contact or injection drug use decreased among persons aged 20 and 25 years between 1988 and 1993, but HIV incidence attributed to heterosexual contact was stable or increasing. Notably, in men aged 20 and 25 years, HIV prevalence declined by about 50% in white men but was relatively stable in black and Hispanic men. In contrast, HIV prevalence in women aged 20 and 25 years rose by 36% and 45%, respectively, because of increasing heterosexual transmission. Overall, HIV prevalence in persons aged 20 and 25 years declined by only 14% between 1988 and 1993.Conclusions: In young persons, HIV incidence in homosexual men and injection drug users was slowing by 1993; this favorable trend was offset by increasing heterosexual transmission, especially in minorities.
SN  - 0098-7484
AD  - Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892, USA
AD  - National Cancer Institute, 6130 Executive Blvd, EPN/403, Rockville, MD 20892. E-mail: philip_rosenberg@nih.gov
U2  - PMID: 9634261.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107268877&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107272220
T1  - Spectrum of AIDS-associated malignant disorders.
AU  - Goedert JJ
AU  - Cote TR
AU  - Virgo P
AU  - Scoppa SM
AU  - Kingma DW
AU  - Gail MH
AU  - Jaffe ES
AU  - Biggar RJ
Y1  - 1998/06/20/
N1  - Accession Number: 107272220. Corporate Author: AIDS-Cancer Match Study Group. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Partial support for this study was provided by National Cancer Institute contracts NO1-CP-40521 with Research Triangle Institute and NO1-CP-40514 with Information Management Service Inc, and by interagency agreement YO1-CP-0003-01 with the US Department of Energy (Oak Ridge National Laboratories). NLM UID: 2985213R. 
KW  - Neoplasms -- Epidemiology
KW  - Acquired Immunodeficiency Syndrome -- Complications
KW  - Confidence Intervals
KW  - Relative Risk
KW  - Registries, Disease
KW  - United States
KW  - Disease Surveillance
KW  - Risk Factors
KW  - Incidence
KW  - Prevalence
KW  - Epidemiological Research
KW  - Sarcoma, Kaposi's -- Epidemiology
KW  - Lymphoma, Non-Hodgkin's -- Epidemiology
KW  - Funding Source
KW  - Human
SP  - 1833
EP  - 1839
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 351 North American Edition
IS  - 9119
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Viral Epidemiology Branch, National Cancer Institute, Rockville
U2  - PMID: 9652666.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107272220&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107154282
T1  - Association of muscle strength with maximum walking speed in disabled older women.
AU  - Rantanen T
AU  - Guralnik JM
AU  - Izmirlian G
AU  - Williamson JD
AU  - Simonsick EM
AU  - Ferrucci L
AU  - Fried LP
Y1  - 1998/07//1998 Jul-Aug
N1  - Accession Number: 107154282. Language: English. Entry Date: 19990101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8803677. 
KW  - Disabled
KW  - Walking
KW  - Muscle Strength
KW  - Muscle Weakness -- Physiopathology
KW  - Exercise Test, Muscular
KW  - Dynamometry
KW  - Knee Joint
KW  - Leg -- Physiopathology
KW  - Torque
KW  - Stratified Random Sample
KW  - Chi Square Test
KW  - Pearson's Correlation Coefficient
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 299
EP  - 305
JO  - American Journal of Physical Medicine & Rehabilitation
JF  - American Journal of Physical Medicine & Rehabilitation
JA  - AM J PHYS MED REHABIL
VL  - 77
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Our aim was to study the association of lower limb strength with maximum walking speed in disabled older women and to try to detect the reserve capacity threshold for maximum walking speed and the minimum strength required for walking at a speed of 1.22 m x s(-1), which is required in crossing signaled intersections. The data are from the baseline of Women's Health and Aging Study, a population-based study on causes and course of disability. Altogether, 1,002 disabled women participated in the tests, which took place at their homes. Maximum isometric hip flexion and knee extension forces were measured on both sides using a handheld dynamometer. For analytic purposes, knee extension torque/body mass ratio (KET/BM) was calculated. Maximum walking speed was measured with a stopwatch during a 4-m walk. KET/BM had a significant effect on walking speed after controlling for number of chronic conditions, balance, use of walking aid, joint pain, age, and body height and mass. A total of 42.3% of the variation in maximum walking speed was explained by these variables. The cumulative percentage distribution of KET/BM of those able to attain a maximum walking speed of 1.22 m x s(-1) (n = 148) was flat to the level of 1.1 N x m x kg(-1), after which it turned upward, indicating that the probability of attaining 1.22 m x s(-1) started to increase after that level. By using segmented linear regression analysis, 2.3 N x m x kg(-1) was found to be the cutoff point beyond which an increase in KET/BM did not correspond to an increase in maximum walking speed. Muscle strength was positively but not linearly associated with maximum walking speed. Strength testing may help to identify people close to functional thresholds and, thus, at risk of impaired walking, who would benefit most from strengthening exercises.
SN  - 0894-9115
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C-309, Bethesda, Maryland 20892
U2  - PMID: 9715919.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107154282&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hyland, Andrew
AU  - Cummings, K. Michael
AU  - Shopland, Donald R.
AU  - Lynn, William R.
T1  - Prevalence of Cigar Use in 22 North American Communities: 1989 and 1993.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1998/07//
VL  - 88
IS  - 7
M3  - Article
SP  - 1086
EP  - 1086
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined the prevalence rate of and characteristics associated with cigar use. Methods. Data were derived from population-based telephone surveys of adults conducted in 22 North American communities in 1989 and 1993 as part of the National Cancer Institute's Community Intervention Trial for Smoking Cessation. Results. Averaged across the 22 communities, the prevalence rate of regular cigar use increased 133% from 1989 to 1993. Regular cigar use increased in every gender, age, race, income, education, and smoking status category. Conclusion. These results confirm other data indicating that cigar use is increasing. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOBACCO use
KW  - SMOKING cessation
KW  - CIGAR smoking
KW  - CIGAR smoke
KW  - CIGARETTE smokers
KW  - RESEARCH
KW  - TOBACCO -- Physiological effect
KW  - SMOKING
KW  - PHYSIOLOGICAL aspects
N1  - Accession Number: 817324; Hyland, Andrew 1 Cummings, K. Michael 1; Email Address: mcunnings@sc3102.med.buffalo.edu Shopland, Donald R. 2 Lynn, William R. 3; Affiliation:  1: Department of Cancer Control and Epidemiology, Roswell Park Cancer Institute, Buffalo, NY  2: Smoking and Tobacco Control Program, National Cancer Institute, Rockville, Md.  3: Cancer Control Science Program, National Cancer Institute; Source Info: Jul98, Vol. 88 Issue 7, p1086; Subject Term: TOBACCO use; Subject Term: SMOKING cessation; Subject Term: CIGAR smoking; Subject Term: CIGAR smoke; Subject Term: CIGARETTE smokers; Subject Term: RESEARCH; Subject Term: TOBACCO -- Physiological effect; Subject Term: SMOKING; Subject Term: PHYSIOLOGICAL aspects; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2669
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Miyazaki, H.;
AU  - Miyazaki, Y.;
AU  - Geber, A.;
AU  - Parkinson, T.;
AU  - Bennett, J. E.;
AU  - \ET/;
T1  - Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata
CT  - Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata
JO  - Antimicrobial Agents and Chemotherapy (USA)
JF  - Antimicrobial Agents and Chemotherapy (USA)
Y1  - 1998/07/01/
VL  - 42
IS  - Jul
SP  - 1695
EP  - 1701
SN  - 00664804
AD  - Clin. Ctr., Rm. 11C304, NIH, Bethesda, MD 20892, USA Internet: jb46y@nih.gov
N1  - Accession Number: 36-14050; Language: English; Chemical Name: Fluconazole--86386-73-4; Therapeutic Class: (8:12.04); AHFS Class: Antifungals fluconazole; References: 40; Journal Coden: AMACCQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Microbiology; Abstract Author: Ramune T. Dailide
N2  - The case of a 45-yr-old man with advanced human immunodeficiency virus type 1 (HIV-1) infection and a 4-yr history of recurrent oropharyngeal candidiasis who responded poorly to increasing doses of fluconazole is presented; mouth cultures were obtained every 2 wk during treatment for the candidiasis. The patient was referred because his oropharyngeal candidiasis was not responding to 200 mg of fluconazole daily. A mouth culture grew \IT/Candida albicans\OK/ and \IT/C. glabrata\OK/. The patient's dose of fluconazole was increased to 400 mg daily, but after 4 wk he had only achieved a partial response. Fluconazole was increased to 800 mg daily for 4 wk, after which no oropharyngeal lesions were detected. Prophylaxis with 200 mg of fluconazole daily was restarted. After 2 wk, oropharyngeal candidiasis recurred. During each of his 6 clinic visits, \IT/C. glabrata\OK/ and \IT/C. albicans\OK/ isolates were obtained, except at wk 6 and 8, when only \IT/C. glabrata\OK/ was obtained. The mouth cultures showed that fluconazole-susceptible colonies of \IT/C. glabrata\OK/ were replaced by resistant colonies that exhibited both increased fluconazole efflux and increased transcription of the drug transporter gene PHD1.
KW  - Fluconazole--resistance-;
KW  - Antifungals--fluconazole--resistance;
KW  - Resistance--fluconazole--C. glabrata;
KW  - Candida glabrata--resistance--fluconazole;
KW  - Candidiasis--fluconazole--HIV infections;
KW  - HIV infections--fluconazole--oropharyngeal candidiasis;
KW  - Dosage--fluconazole--resistance;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=36-14050&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107173125
T1  - Diagnosis and management of anxiety in the geriatric patient.
AU  - Bakey AA
AU  - Levy JK
AU  - Fernandez F
Y1  - 1998/07//1998 Jul
N1  - Accession Number: 107173125. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9716897. 
KW  - Anxiety -- In Old Age
KW  - Gerontologic Care
KW  - Anxiety -- Epidemiology -- In Old Age
KW  - Anxiety -- Diagnosis -- In Old Age
KW  - Anxiety -- Drug Therapy -- In Old Age
KW  - Anxiety -- Therapy -- In Old Age
KW  - Phobic Disorders -- Diagnosis -- In Old Age
KW  - Diagnosis, Differential
KW  - Antianxiety Agents -- Therapeutic Use -- In Old Age
KW  - Antianxiety Agents, Benzodiazepine -- Adverse Effects -- In Old Age
KW  - Psychotherapy
KW  - Aged
SP  - 10
EP  - 21
JO  - Clinical Geriatrics
JF  - Clinical Geriatrics
JA  - CLIN GERIATR
VL  - 6
IS  - 8
CY  - New York, New York
PB  - American Geriatrics Society
AB  - Anxiety disorders have significant comorbidity with other psychiatric and medical disorders in the elderly and are underdiagnosed in this age group. General mortality in the older patient with anxiety has indeed been shown to be significantly higher in comparison to the older patient without this problem. The authors discuss the prevalence of anxiety disorders, as well as their diagnosis and management in elderly individuals. They review the various treatment options available, including pharmacotherapeutic and psychotherapeutic choices. They emphasize the importance of improving the patient's quality of life.
SN  - 1070-1389
AD  - Visiting Scientist, Clinical Brain Disorders Branch, National Institute of Mental Health Neuroscience Center, St. Elizabeth's, Washington, DC
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107280244
T1  - Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993.
AU  - Gu K
AU  - Cowie CC
AU  - Harris MI
Y1  - 1998/07//
N1  - Accession Number: 107280244. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Diabetes Mellitus -- Mortality -- United States
KW  - Mortality -- United States
KW  - United States
KW  - Prospective Studies
KW  - Kaplan-Meier Estimator
KW  - Interviews
KW  - Cox Proportional Hazards Model
KW  - P-Value
KW  - Risk Factors
KW  - Life Expectancy
KW  - Sex Factors
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1138
EP  - 1145
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 21
IS  - 7
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To examine 22-year mortality (1971-1993), causes of death, life expectancy, and survival in a national sample of diabetic and nondiabetic adults according to age, sex, and race. RESEARCH DESIGN AND METHODS: A representative national cohort of 14,374 adults aged 25-74 years was identified in 1971-1975 in the First National Health and Nutrition Examination Survey (NHANESI). Diabetes was ascertained by medical history interview. The cohort was followed for mortality through 1992-1993, with verification of vital status for 96.2% (n = 13,830). Causes of death were determined from death certificates. RESULTS: Diabetic subjects comprised 5.1% of the cohort and accounted for 10.6% of the deaths. Mortality for diabetic subjects increased from 12.4 per 1,000 person-years for those aged 25-44 years at baseline to 89.7 per 1,000 person-years for those aged 65-74 years. The age-adjusted mortality rate was 57% higher for diabetic men than for diabetic women; the rate was 27% higher for diabetic non-Hispanic blacks than for diabetic non-Hispanic whites. Mortality rates were highest for insulin-treated subjects and for those with > or = 15 years' duration of diabetes. Diabetes was listed on the death certificate as the underlying cause of death for only 7.7% of diabetic men and 13.4% of diabetic women. Considering multiple causes of death, heart disease was listed the most frequently and was present on 69.5% of death certificates of people with diabetes. Death rates were higher for diabetic than for nondiabetic subjects in all age, sex, and race groups. The relative risk of death (diabetic versus nondiabetic subjects) declined with age from a value of 3.6 for those aged 25-44 years at baseline to 1.5 for those aged 65-74 years. The relative risk was elevated in diabetic subjects for all major causes of death except malignant neoplasms. Survival of diabetic subjects was lower than that of nondiabetic subjects in all age, sex, and race groups. Median life expectancy was 8 years lower for diabetic adults aged 55-64 years and 4 years lower for those aged 65-74 years. CONCLUSIONS: In this representative national sample of adults, mortality rates were higher for diabetic men than for diabetic women and for diabetic blacks than for diabetic whites. The study confirms the substantially higher risk of death, lower survival, and lower life expectancy of diabetic adults compared with nondiabetic adults.
SN  - 0149-5992
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
U2  - PMID: 9653609.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hoofnagle, Jay H.
T1  - Therapy of Viral Hepatitis.
JO  - Digestion
JF  - Digestion
Y1  - 1998/07//
VL  - 59
IS  - 5
M3  - Article
SP  - 563
EP  - 578
SN  - 00122823
AB  - Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, although use of alpha-interferon during the acute phase of hepatitis C may result in a decrease in the rate of chronicity. For chronic viral hepatitis, alpha-interferon has been widely used, but is expensive, poorly tolerated and limited in effectiveness. New antiviral agents and use of combinations of antivirals are now being evaluated and promise to provide a therapy that is effective in the majority of patients. The currently recommended therapy of chronic hepatitis B is a 4- to 6-month course of alpha-interferon in doses of 5–10 million units three times a week; a regimen that results in sustained clearance of hepatitis B virus (HBV) DNA and hepatitis B e antigen (HBeAg) from serum in approximately one-third and a loss of hepatitis B surface antigen (HBsAg) in one-tenth of patients. Long-term follow-up of patients who respond to interferon treatment with clearance of HBeAg indicate that the majority ultimately clear HBsAg as well and have continued remission in the liver disease, although low levels of HBV DNA can commonly be detected in liver tissue. Better therapies of hepatitis B are needed. Recently, several oral ‘second-generation’ nucleoside analogues have been developed that have potent activity against HBV. The best studied is lamivudine (3-thiacytidine) which results in marked inhibition of HBV DNA levels and improvement in serum aminotransferases and hepatic histology in the majority of patients. When stopped, however, most patients relapse and the shortcomings of long-term therapy have been the development of viral resistance in up to one-quarter of patients within a year and a higher percentage with more prolonged therapy. Future approaches of therapy of promise for hepatitis B are combinations of lamivudine with interferon and other antiviral nucleoside analogues. The currently recommended therapy of chronic hepatitis C is a 12- to 18-month course of alpha interferon in doses of 3 million units three times a week: a regimen that results in sustained clearance of hepatitis C virus (HCV) RNA in approximately 20% of patients. Sustained responses have been associated with marked improvements in hepatic histology and long-term studies indicate that the majority of patients remain free of virus in serum and liver, suggesting a ‘cure’ of infection. Responses to interferon correlate to some degree with clinical and virological features, including young age, absence of hepatic fibrosis, low levels of HCV RNA in serum and HCV genotypes 2 and 3. Most recently, combinations of alpha interferon and ribavirin, an oral nucleoside analogue, have been evaluated and shown to increase the sustained response rate to 30–40%. Better therapies are still needed, as the majority of patients with hepatitis C do not have a sustained response to therapy. Extensive research on the molecular structure of HCV indicates several potential means of inhibition of viral replication, including use of protease and helicase inhibitions. What is most needed to advance the field of therapeutics in hepatitis C is development of animal models and cell culture systems with which to study this important viral cause of liver disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Digestion is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - VIRAL hepatitis
KW  - HEPATITIS -- Treatment
KW  - THERAPEUTICS
KW  - CIRRHOSIS of the liver
KW  - NUCLEOSIDES
KW  - TREATMENT
KW  - Alpha-interferon
KW  - Cirrhosis
KW  - Genotypes
KW  - Hepatitis B virus
KW  - Hepatitis C virus
KW  - Hepatitis D virus
KW  - Nucleoside analogues
KW  - Randomized controlled trials
N1  - Accession Number: 11372872; Hoofnagle, Jay H. 1; Email Address: Hoofnaglej@hq.niddk.nih.gov; Affiliation:  1: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 59 Issue 5, p563; Subject Term: VIRAL hepatitis; Subject Term: HEPATITIS -- Treatment; Subject Term: THERAPEUTICS; Subject Term: CIRRHOSIS of the liver; Subject Term: NUCLEOSIDES; Subject Term: TREATMENT; Author-Supplied Keyword: Alpha-interferon; Author-Supplied Keyword: Cirrhosis; Author-Supplied Keyword: Genotypes; Author-Supplied Keyword: Hepatitis B virus; Author-Supplied Keyword: Hepatitis C virus; Author-Supplied Keyword: Hepatitis D virus; Author-Supplied Keyword: Nucleoside analogues; Author-Supplied Keyword: Randomized controlled trials; Number of Pages: 16p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3  - 10.1159/000007532
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11372872&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wuyts, Anja
AU  - Proost, Paul
AU  - Lenaerts, Jean-Pierre
AU  - Ben-Baruch, Adit
AU  - Van Damme, Jo
AU  - Wang, Ji Ming
T1  - Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1998/07//Jul98 Part 1
VL  - 255
IS  - 1
M3  - Article
SP  - 67
EP  - 73
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The inflammatory response is mediated by a family of chemotactic cytokines, designated chemokines. The receptor usage of the CXC chemokine granulocyte chemotactic protein-2 (GCP-2) was compared with that of interleukin-8 (IL-8) and epithelial-cell-derived neutrophil attractant-78 (ENA-78). Chemokine activities were evaluated by measurement of intracellular calcium increase and by chemotaxis and binding assays, using CXC chemokine receptor (CXCR)-transfected cell lines. GCP-2 was equally potent at inducing a rise in [Ca2+]i in both CXCR1-transfected and CXCR2-transfected cells (minimal effective concentration 3 nM). IL-8 augmented the [Ca2+]i more efficiently in CXCR1-transfectants than in CXCR2-transfectants, whereas for ENA-78, threefold higher concentrations were necessary to obtain a calcium response in CXCR1-transfected cells than in CXCR2-transfectants. GCP-2 desensitized the calcium increase induced by IL-8 in both CXCR1-transfected and CXCR2-transfected cells, but ENA-78 only affected the IL-8-induced calcium response in CXCR2-transfectants. The half-maximal effective concentrations for migration of CXCR2-transfectants in response to GCP-2 and ENA-78 were similar (0.1 nM), whereas GCP-2 was tenfold more potent than ENA-78 on CXCR1-transfectants. Half-maximal migration of CXCR1-transfected and CXCR2-transfected cells was obtained with IL-8 at concentrations of no more than 0.01 nM. Radiolabeled IL-8 could efficiently be displaced from CXCR2 by IL-8, GCP-2 and ENA-78. In contrast, only IL-8 and GCP-2 but not ENA-78, competed for 125I-IL-8 binding to CXCR1. From these data, it can be concluded that, in addition to IL-8, GCP-2, but not ENA-78, efficiently binds to both CXCR1 and CXCR2. The differential receptor usage of the structurally related ELR+CXC chemokines GCP-2 and ENA-78 is indicative of a different role in inflammatory reactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHEMOKINES
KW  - LEUCOCYTES
KW  - calcium
KW  - chemokine
KW  - chemotaxis
KW  - desensitization
KW  - receptor.
N1  - Accession Number: 5276482; Wuyts, Anja 1 Proost, Paul 1 Lenaerts, Jean-Pierre 1 Ben-Baruch, Adit 2 Van Damme, Jo 1 Wang, Ji Ming 2; Affiliation:  1: Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium  2: Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, USA; Source Info: Jul98 Part 1, Vol. 255 Issue 1, p67; Subject Term: CHEMOKINES; Subject Term: LEUCOCYTES; Author-Supplied Keyword: calcium; Author-Supplied Keyword: chemokine; Author-Supplied Keyword: chemotaxis; Author-Supplied Keyword: desensitization; Author-Supplied Keyword: receptor.; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3  - 10.1046/j.1432-1327.1998.2550067.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schrager, Lewis K.
AU  - D'Souza, Patricia
AU  - Schrager, L K
AU  - D'Souza, M P
T1  - Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1998/07//7/1/98
VL  - 280
IS  - 1
M3  - journal article
SP  - 67
EP  - 71
SN  - 00987484
AB  - The eradication of human immunodeficiency virus 1 (HIV-1) from infected persons is the ultimate goal of HIV therapeutic interventions. Great strides have been made in developing potent antiretroviral regimens that greatly suppress HIV-1 replication. Despite these therapeutic advances, major obstacles remain to eradicating HIV-1. Reservoirs of HIV-1 have been identified that represent major impediments to eradication. Conceptually, there are 2 types of sanctuaries for HIV-1, cellular and anatomical. Cellular sanctuaries may include latent CD4+ T cells containing integrated HIV-1 provirus; macrophages, which may express HIV-1 for prolonged periods; and follicular dendritic cells, which may hold infectious HIV-1 on their surfaces for indeterminate lengths of time. The key anatomical reservoir for HIV-1 appears to be the central nervous system. An understanding of the nature of HIV within these reservoirs is critical to devising strategies to hasten viral eradication. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV infections -- Treatment
KW  - CENTRAL nervous system
KW  - ANTI-HIV agents
KW  - COMBINATION drug therapy
KW  - DENDRITIC cells
KW  - HIV (Viruses)
KW  - HIV infections
KW  - MACROPHAGES
KW  - T cells
KW  - DRUGS -- Physiological effect
KW  - INFECTIONS
KW  - THERAPEUTIC use
N1  - Accession Number: 775407; Schrager, Lewis K. D'Souza, Patricia Schrager, L K 1 D'Souza, M P; Affiliation:  1: Epidemiology Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA; Source Info: 7/1/98, Vol. 280 Issue 1, p67; Subject Term: HIV infections -- Treatment; Subject Term: CENTRAL nervous system; Subject Term: ANTI-HIV agents; Subject Term: COMBINATION drug therapy; Subject Term: DENDRITIC cells; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: MACROPHAGES; Subject Term: T cells; Subject Term: DRUGS -- Physiological effect; Subject Term: INFECTIONS; Subject Term: THERAPEUTIC use; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zoeteweij, J. Paul
AU  - Blauvelt, Andrew
T1  - HIV-Dendritic Cell Interactions Promote Efficient Viral Infection of T Cells.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1998/07//
VL  - 5
IS  - 4
M3  - Article
SP  - 253
EP  - 259
PB  - BioMed Central
SN  - 10217770
AB  - Dendritic cells (DC) are bone marrow-derived leukocytes that act as powerful stimulators of primary and secondary immune responses. Langerhans cells (LC), which are immature DC in epidermis and genital mucosa, are generally believed to be the initial cells infected with HIV following mucosal exposure to virus. Interestingly, freshly isolated LC express the HIV coreceptor CCR5, but not CXCR4, on their cell surfaces. This expression pattern would theoretically allow only macrophage-tropic [and not T cell (TC)-tropic] HIV to be transmitted across intact mucosal epithelium. In vitro, it is known that HIV infects LC (and other DC) in a CD4- and HIV coreceptor-dependent manner. In addition, HIV can be captured by prominent stellate processes on the surface of LC/DC. HIV-infected DC, as well as DC that have captured HIV, efficiently transmit virus to TC during antigen-specific TC activation. Thus, DC may be involved in HIV plasma viremia increases observed following antigenic exposure, e.g. immunizations, in chronically HIV-infected individuals by (1) activating latently infected TC or (2) activating and transmitting virus to new target TC. In summary, DC most likely play a major role in primary HIV infection by allowing virus to breach mucosal surfaces, and can act during both initial and chronic phases of HIV disease by facilitating infection and depletion of TC. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENDRITIC cells
KW  - ANTIGEN presenting cells
KW  - LANGERHANS cells
KW  - T cells
KW  - HIV (Viruses)
KW  - CCR5
KW  - Coreceptors
KW  - CXCR4
KW  - HIV
KW  - Langerhans cells
N1  - Accession Number: 11378130; Zoeteweij, J. Paul 1 Blauvelt, Andrew 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Md., USA; Source Info: 1998, Vol. 5 Issue 4, p253; Subject Term: DENDRITIC cells; Subject Term: ANTIGEN presenting cells; Subject Term: LANGERHANS cells; Subject Term: T cells; Subject Term: HIV (Viruses); Author-Supplied Keyword: CCR5; Author-Supplied Keyword: Coreceptors; Author-Supplied Keyword: CXCR4; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Langerhans cells; Number of Pages: 7p; Document Type: Article
L3  - 10.1159/000025337
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 88458410
T1  - Tumor lysis syndrome: an uncommon complication of fludarabine therapy of chronic lymphocytic leukemia.
AU  - Cheson, Bruce D.
AU  - Frame, James N.
AU  - Vena, Don
AU  - Quashu, Nadine
AU  - Sorensen, J. Mel
AU  - Cheson, B D
AU  - Frame, J N
AU  - Vena, D
AU  - Quashu, N
AU  - Sorensen, J M
Y1  - 1998/07//
N1  - Accession Number: 88458410. Language: English. Entry Date: 19990201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). NLM UID: 8309333. 
KW  - Leukemia, Lymphocytic, Chronic -- Drug Therapy
KW  - Tumor Lysis Syndrome -- Etiology
KW  - Vidarabine -- Analogs and Derivatives
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Treatment Outcomes
KW  - Retrospective Design
KW  - Male
KW  - Aged
KW  - Aged, 80 and Over
KW  - Tumor Lysis Syndrome -- Blood
KW  - Adult
KW  - Tumor Lysis Syndrome -- Therapy
KW  - Middle Age
KW  - Vidarabine -- Adverse Effects
KW  - Female
KW  - Incidence
KW  - Survival Analysis
KW  - Severity of Illness Indices
KW  - Leukemia, Lymphocytic, Chronic -- Blood
KW  - Scales
SP  - 2313
EP  - 2320
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To quantify the incidence and severity of tumor lysis syndrome (TLS) as a consequence of fludarabine therapy in patients with advanced chronic lymphocytic leukemia (CLL).Patients and Methods: A retrospective review and questionnaire follow-up of clinical and laboratory data were performed on patients with intermediate or high-risk CLL on the National Cancer Institute Group C protocol or special exception mechanisms, or phase II trials of fludarabine, for whom adverse drug reports of TLS were available. Fludarabine was administered at a dose of 20 to 40 mg/m2 per day for 5 days at monthly intervals.Results: Among the 6,137 patients, TLS was suspected in 26 (0.42%), with clinical and laboratory features consistent with TLS present in 20 (0.33%). Prophylaxis against TLS had been administered to 60% of these patients. Clinical or laboratory features were similar to patients who did not develop TLS. Of the patients with TLS, 90% had high-risk CLL, 60 months of prior disease duration, with a median pretreatment WBC of 109 x 10(9)/L, two prior regimens, lymphadenopathy in 89%, splenomegaly and/or hepatomegaly in 90%. TLS developed on approximately day 7 and lasted a median of 9.5 days. Dialysis was required in 30% during the TLS episode; 20% of patients died during cycle one of fludarabine therapy with renal failure, and another 20% died of infection or congestive heart failure. Six patients were retreated with fludarabine without recurrent TLS.Conclusion: TLS after fludarabine therapy is extremely uncommon, but may be associated with significant morbidity and mortality.
SN  - 0732-183X
AD  - Cancer Therapy Evaluation Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute
AD  - Department of Internal Medicine, Divisions of Hematology and Medical Oncology, National Naval Medical Center, Bethesda
AD  - EMMES Corp, Potomac, MD
AD  - Cancer Therapy Evaluation Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Bethesda, MD 20892, USA
U2  - PMID: 9667245.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 88458414
T1  - Phase II and dose-escalation with or without granulocyte colony-stimulating factor study of 9-aminocamptothecin in relapsed and refractory lymphomas.
AU  - Wilson, Wyndham H.
AU  - Little, Richard
AU  - Pearson, Debra
AU  - Jaffe, Elaine S.
AU  - Steinberg, Seth M.
AU  - Cheson, Bruce D.
AU  - Humphrey, Rachel
AU  - Kohler, David R.
AU  - Elwood, Patrick
AU  - Wilson, W H
AU  - Little, R
AU  - Pearson, D
AU  - Jaffe, E S
AU  - Steinberg, S M
AU  - Cheson, B D
AU  - Humphrey, R
AU  - Kohler, D R
AU  - Elwood, P
Y1  - 1998/07//
N1  - Accession Number: 88458414. Language: English. Entry Date: 19990201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Impact of Events Scale (IES). NLM UID: 8309333. 
KW  - Lymphoma -- Drug Therapy
KW  - Camptothecin -- Analogs and Derivatives
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Granulocyte Colony-Stimulating Factor -- Therapeutic Use
KW  - Female
KW  - Camptothecin -- Adverse Effects
KW  - Recurrence
KW  - Drug Resistance, Neoplasm
KW  - Middle Age
KW  - Adult
KW  - Aged
KW  - Drug Administration Schedule
KW  - Camptothecin -- Administration and Dosage
KW  - Human
KW  - Male
KW  - Infusions, Intravenous
KW  - Prognosis
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Lymphoma -- Pathology
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Randomized Controlled Trials
KW  - Impact of Events Scale
SP  - 2345
EP  - 2351
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To assess the efficacy and maximum dose-intensity of a new topoisomerase I (topo I)-targeting agent, 9-aminocamptothecin (9-AC), in patients with relapsed or refractory lymphomas.Patients and Methods: Eligible patients had measurable disease and were considered incurable. 9-AC was infused over 72 hours at an initial dose rate of 40 microg/m2/h every 3 weeks with subsequent intrapatient escalations or reductions in 10-microg/m2/h increments based on toxicity. To assess the impact of granulocyte-colony stimulating factor (G-CSF) on dose-intensity, the first 16 patients received no G-CSF and the subsequent 29 patients received G-CSF on all cycles.Results: Forty-five patients received a total of 142 cycles of 9-AC. The patients' median age was 55 years, 73% had stage IV disease, and histologies included indolent and aggressive non-Hodgkin's lymphoma (NHL) in 33% and 58% of patients, respectively, and Hodgkin's lymphoma in 9%. Patients had received a median of two prior chemotherapy regimens, and 67% of patients had chemotherapy-sensitive disease. Of 40 assessable patients, 10 (25%) achieved a partial response (PR). Chemotherapy-sensitive patients had a 32% response rate compared with 8% in chemotherapy-resistant patients. With a median follow-up duration of 35 months, the median event-free survival (EFS) and overall survival times were 1.5 and 12.5 months, respectively, and the median duration of response was 5 months (range, 1 to 10). G-CSF significantly reduced the incidence of neutropenia and diarrhea, but did not permit a significant increase in dose-intensity.Conclusion: 9-AC had a reasonable response rate of 25% in heavily pretreated patients. The low response rate in patients with chemotherapy-resistant disease suggests that there is cross-resistance between 9-AC and standard chemotherapy. However, there was no association between 9-AC response and the number of prior regimens. Due to dose-limiting thrombocytopenia, G-CSF support did not increase dose-intensity, although individual patients benefited from the use of G-CSF.
SN  - 0732-183X
AD  - Medicine Branch, HIV and AIDS Malignancy Branch, Biostatistics and Data Management Section, Division of Clinical Sciences, and Cancer Therapy Evaluation Program, Division of Cancer Treatment and Centers, National Cancer Institute
AD  - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD
AD  - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
U2  - PMID: 9667249.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=88458414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bouloc, Anne
AU  - Cavani, Andrea
AU  - Katz, Stephen I.
T1  - Contact Hypersensitivity in MHC Class II‐Deficient Mice Depends on CD8 T Lymphocytes Primed by Immunostimulating Langerhans Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/07//
VL  - 111
IS  - 1
M3  - Article
SP  - 44
EP  - 49
SN  - 0022202X
AB  - Studies to determine if CD4+ and/or CD8+ T cells are critical for the initiation and propagation of contact hypersensitivity (CHS) reactions have yielded conflicting results regarding their roles. We studied the induction and expression of CHS to trinitrochlorobenzene (TNCB) using major histocompatibility complex class II‐deficient mice that display normal numbers of CD8+ T cells but lack CD4+ T cells. CHS to TNCB, detected as an increase in ear thickness 24 h after epicutaneous challenge, was significantly enhanced in major histocompatibility complex class II‐deficient mice compared with wild‐type controls. Ear swelling responses in major histocompatibility complex class II‐deficient mice were decreased by treatment with anti‐CD8 antibody or by injection of wild‐type CD4+ T cells. To further characterize mechanisms involved in the initiation of CHS responses, phenotypical and functional characteristics of both freshly isolated and cultured Langerhans cells were studied. Like Langerhans cells from wild‐type controls, Langerhans cells from major histocompatibility complex class II‐deficient mice upregulated B7–1 and B7–2 costimulatory molecules and enhanced major histocompatibility complex class I expression upon short‐term culture. Cultured Langerhans cells induced a 3.5‐fold increase in the stimulation of autologous hapten‐specific CD8+ T cell proliferation compared with fresh Langerhans cells. Finally, TNP‐coupled Langerhans cells from major histocompatibility complex class II‐deficient mice primed naïve mice to TNCB after transfer. These results demonstrate that hapten‐specific CD8+ T cells are sufficient for the expression of CHS and that CD8 priming does not require the presence of CD4+ T cells or major histocompatibility complex class II antigen. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CONTACT dermatitis
KW  - CHLORONITROBENZENES
KW  - CD4 antigen
KW  - MAJOR histocompatibility complex
N1  - Accession Number: 5661569; Bouloc, Anne Cavani, Andrea 1 Katz, Stephen I. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul98, Vol. 111 Issue 1, p44; Subject Term: CONTACT dermatitis; Subject Term: CHLORONITROBENZENES; Subject Term: CD4 antigen; Subject Term: MAJOR histocompatibility complex; Number of Pages: 6p; Illustrations: 28 Graphs; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00236.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5661569&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ishiko, Akira
AU  - Shimizu, Hiroshi
AU  - Masunaga, Takuji
AU  - Yancey, Kim B.
AU  - Giudice, George J.
AU  - Zone, John J.
AU  - Nishikawa, Takeji
T1  - 97 kDa Linear IgA Bullous Dermatosis Antigen Localizes in the Lamina Lucida Between the NC16A and Carboxyl Terminal Domains of the 180 kDa Bullous Pemphigoid Antigen.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/07//
VL  - 111
IS  - 1
M3  - Article
SP  - 93
EP  - 96
SN  - 0022202X
AB  - Linear IgA bullous dermatosis is an autoimmune blistering disease characterized by circulating IgA anti‐basement membrane autoantibodies. A 97 kDa protein (97‐LAD), which localizes at the basement membrane zone of normal human skin, is one of the major autoantigens associated with this disease and possesses multiple regions of amino acid identity with the extracellular domain of the 180 kDa bullous pemphigoid antigen, BPAG2. To investigate further the relationship between 97‐LAD and BPAG2, immunogold electron microscopy was performed on cryo‐ultrathin sections of normal human skin using a series of polyclonal and monoclonal antibodies. Gold particles immunolabeling two newly developed monoclonal antibodies against 97‐LAD were localized to the lamina lucida. This immunolabeling pattern was associated with hemidesmosomes and localized at a mean distance of 28 nm beneath the plasma membrane of basal keratinocytes. In contrast, polyclonal antibodies against a fusion protein containing the NC16A domain of BPAG2 immunolabeled the plasma membrane of the hemidesmosomal complex, whereas polyclonal antibodies against the carboxyl terminus mainly immunolabeled the lower lamina lucida with a mean distance of 42 nm beneath the plasma membrane. By double immunolabeling, 97‐LAD was localized as if being sandwiched between the NC16A and the carboxyl terminal domains of BPAG2. These results clearly demonstrated the co‐localization of 97‐LAD and the extracellular portion of BPAG2 in the lamina lucida, and suggested that 97‐LAD is closely related to, and/or forms a complex with, the extracellular domain of BPAG2. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - ANTIGENS
KW  - SKIN
N1  - Accession Number: 5661573; Ishiko, Akira 1,2 Shimizu, Hiroshi 1 Masunaga, Takuji 2 Yancey, Kim B. 3 Giudice, George J. 4 Zone, John J. 5 Nishikawa, Takeji 2; Affiliation:  1: *Department of Dermatology, Nippon Kokan Hospital, Kawasaki, Kanagawa, Japan;  2: †Keio University School of Medicine, Tokyo, Japan;  3: ‡Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.;  4: §Department of Dermatology and Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.;  5: ¶Medicine Service, Section of Dermatology, Salt Lake City Veterans Affairs Medical Center and Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah, U.S.A.; Source Info: Jul98, Vol. 111 Issue 1, p93; Subject Term: PROTEINS; Subject Term: ANTIGENS; Subject Term: SKIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Illustrations: 4 Black and White Photographs, 2 Graphs; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00231.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5661573&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107193384
T1  - The human capsaicin model of allodynia and hyperalgesia: sources of variability and methods for reduction.
AU  - Liu M
AU  - Max MB
AU  - Robinovitz E
AU  - Gracely RH
AU  - Bennett GJ
Y1  - 1998/07//1998 Jul
N1  - Accession Number: 107193384. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Visual Analog Scaling. NLM UID: 8605836. 
KW  - Capsaicin -- Pharmacodynamics
KW  - Pain -- Drug Therapy
KW  - Clinical Trials
KW  - Crossover Design
KW  - Pain Measurement
KW  - Visual Analog Scaling
KW  - Neuropsychological Tests
KW  - Linear Regression
KW  - Correlation Coefficient
KW  - Analysis of Variance
KW  - Repeated Measures
KW  - Skin Temperature
KW  - Descriptive Statistics
KW  - P-Value
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 10
EP  - 20
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 16
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
AB  - Intradermal and topical application of capsaicin have been used to study mechanisms of mechanical allodynia (MA) and pinprick hyperalgesia (PPH) and the efficacy of drugs in relieving these symptoms. However, it is associated with significant inter- and intra-subject variability. In order to improve the model's sensitivity, we examined several potential sources of variability of capsaicin-evoked MA and PPH in healthy volunteers, including skin temperature fluctuations, method (intradermal vs. topical) and site (volar forearm vs. foot dorsum) of administration. In study I, 12 subjects received, in a 6-session, randomized, crossover trial, 1) 250 micrograms of intradermal (ID) CAP to the volar forearm with skin temperature fixed at 36 degrees C (36 ID). 2) 250 micrograms ID CAP with varying skin temperature (VT ID), or 3) 250 microliters of l% CAP patch placed on the skin at 36 degrees C. The resulting MA and PPH areas observed with each method were measured. In study II, a 4-session, randomized crossover trial, 12 subjects were given 100 micrograms ID CAP in the volar forearm or foot dorsum and subsequent areas of MA and PPH recorded. In study I, 5/12 subjects had small MA areas (< or = 5 cm2) and one subject had small PPH areas in at least 4/6 sessions. The most consistent intra-subject responses were seen with the 36 ID method. Correlation coefficients for the two sessions using the same method of administration were: MA; 36 ID r = 0.83, VT ID = 0.19. Topical r = 0.81; PPH: 36 ID r = 0.93; VT ID r = 0.38, Topical r = 0.78. In study II, 4/12 subjects had little MA for both forearm and foot though all subjects developed PPH. However, greater intra-subject consistency (MA: foot: r = 0.84; arm: r = 0.49; PPH: r = 0.87; r = 0.39) and significantly larger areas of MA (15.8 +/- 4.2 vs 9.1 +/- 2.5, p < 0.05) were seen with the foot. (PPH: foot: 28.9 +/- 6.7; arm: 21.6 +/- 4.2, NS). Large variability exists among subjects receiving CAP, with some developing minimal MA. However, these subjects may be screened out prior to entry, increasing the sensitivity of the model, which may be further improved by clamping the skin temperature. (c) U.S. Cancer Pain Relief Committee, 1998 Published by Elsevier, New York, New York
SN  - 0885-3924
AD  - Neurobiology and Anesthesiology Branch, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9707653.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107193384&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107223633
T1  - Emotional vitality among disabled older women: the Women's Health and Aging Study.
AU  - Penninx BWJ
AU  - Guralnik JM
AU  - Simonsick EM
AU  - Kasper JD
AU  - Ferrucci L
AU  - Fried LP
Y1  - 1998/07//1998 Jul
N1  - Accession Number: 107223633. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Geriatric Depression Scale (GDS); Mini-Mental Status Examination (MMSE) (Folstein et al); Perceived Quality of Life Scale (PQOL); Hopkins Symptom Checklist (HSCL) - 4-item version of the Anxiety Subscale. Grant Information: Dutch Niels Stensen Stichting. NLM UID: 7503062. 
KW  - Aging -- Psychosocial Factors
KW  - Disabled -- Psychosocial Factors
KW  - Emotions
KW  - Women
KW  - Maryland
KW  - Health Status
KW  - Interpersonal Relations
KW  - Psychological Tests
KW  - Quality of Life
KW  - Socioeconomic Factors
KW  - Funding Source
KW  - Odds Ratio
KW  - Coefficient Alpha
KW  - Mantel-Haenszel Test
KW  - Chi Square Test
KW  - Logistic Regression
KW  - Confidence Intervals
KW  - Data Analysis Software
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 807
EP  - 815
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
VL  - 46
IS  - 7
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVE: To examine correlates of high overall level of emotional functioning (emotional vitality) in disabled older women. DESIGN: A community-based study: The Women's Health and Aging Study. POPULATION: A total of 1002 moderately to severely disabled women aged 65 and older living in the community. MEASUREMENTS: Emotional vitality was defined as having a high sense of personal mastery, being happy, and having low depressive symptomatology and anxiety. Correlations with demographics, health status, and social context were examined. RESULTS: Despite their physical disabilities, 35% of the 1002 disabled older women were emotionally vital. The percent of emotionally vital women declined with increasing severity of disability. After adjustment for disability status, a significantly increased likelihood for being emotionally vital was found for black race (OR=1.69) and for having higher income (OR=1.77), better cognition (OR=2.36), no vision problems (OR=1.61), adequate emotional support (OR=2.54), and many face-to-face contacts (OR=1.64). Having more than one negative life event reduced the likelihood of emotional vitality (OR=0.57). CONCLUSION: A substantial proportion of even the most disabled older women can be described as emotionally vital. Findings also suggest that emotional vitality is not solely a function of stable, enduring individual characteristics but that health status, disability, and sociodemographic context also have an influence on emotional vitality.
SN  - 0002-8614
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Gateway Bldg. Suite 3C-309, Bethesda, MD 20892-9205
U2  - PMID: 9670865.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107223633&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107185306
T1  - Physical disability and social interaction: factors associated with low social contact and home confinement in disabled older women (the Women's Health and Aging Study)
AU  - Simonsick EM
AU  - Kasper JD
AU  - Phillips CL
Y1  - 1998/07//
N1  - Accession Number: 107185306. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Supported by National Institute on Aging contract N01-AG-1-2112. NLM UID: 9508483. 
KW  - Social Isolation -- In Old Age
KW  - Disabled -- In Old Age
KW  - Interpersonal Relations -- In Old Age
KW  - Homebound Patients
KW  - Prospective Studies
KW  - Interviews
KW  - Descriptive Statistics
KW  - Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Race Factors
KW  - Blacks
KW  - Socioeconomic Factors
KW  - Geriatric Functional Assessment
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Funding Source
KW  - Human
SP  - S209
EP  - 17
JO  - Journals of Gerontology Series B: Psychological Sciences & Social Sciences
JF  - Journals of Gerontology Series B: Psychological Sciences & Social Sciences
JA  - J GERONTOL B PSYCHOL SCI SOC SCI
VL  - 53
IS  - 4
PB  - Oxford University Press / USA
AB  - OBJECTIVES: This study examines the association of disability and social interaction, measured as in-person contact with non-household members and home confinement, and identifies sociodemographic, socioeconomic, and health-related factors that modify this relationship. METHODS: Participants were 1,002 moderately to severely disabled community-dwelling women aged 65 and older from the Women's Health and Aging Study, identified by screening an age-stratified random sample of Medicare beneficiaries in Baltimore, Maryland. Logistic regression models were used to estimate the odds of low social interaction associated with disability and each independent modifier. RESULTS: In a typical week, 23% did not visit with anyone residing outside their households and 17% did not leave their homes. In addition to and independent of disability level, older age, not completing high school, having a driver in the home, hearing difficulties and incontinence were associated with low social contact; older age and African American race were related to home confinement. African American women living alone are especially vulnerable to home confinement. DISCUSSION: Physical disability is not necessarily socially disabling, as many of the most severely disabled in our study had at least daily social interaction. Improvements in social interaction appear possible through more effective management of certain health conditions and attention to potential sociocultural barriers.
SN  - 1079-5014
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Suite 3C-309, Bethesda, MD 20892; e-mail: simonsie@gw.nia.nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107185306&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107165628
T1  - Intravenous delivery of 5'-iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancers: results of a pilot study.
AU  - Epstein AH
AU  - Lebovics RS
AU  - Van Waes C
AU  - Smith J
AU  - Okunieff P
AU  - Cook JA
Y1  - 1998/07//
N1  - Accession Number: 107165628. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8607378. 
KW  - Radiation-Sensitizing Agents -- Therapeutic Use
KW  - Carcinoma, Squamous Cell -- Drug Therapy
KW  - Carcinoma, Squamous Cell -- Radiotherapy
KW  - Head and Neck Neoplasms -- Drug Therapy
KW  - Head and Neck Neoplasms -- Radiotherapy
KW  - Combined Modality Therapy
KW  - Survival
KW  - Radiation Dosage
KW  - Disease Remission
KW  - Head and Neck Neoplasms -- Classification
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Cancer Care Facilities
KW  - Maryland
KW  - Pilot Studies
KW  - Prospective Studies
KW  - Treatment Outcomes
KW  - Morbidity -- Classification
KW  - Human
SP  - 1090
EP  - 1094
JO  - Laryngoscope
JF  - Laryngoscope
JA  - LARYNGOSCOPE
VL  - 108
IS  - 7
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0023-852X
AD  - Radiation Oncology Branch, Building 10, Room B3B69, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 9665262.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107165628&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104798586
T1  - Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health.
AU  - Samuels, J
AU  - Aksentijevich, I
AU  - Torosyan, Y
AU  - Centola, M
AU  - Deng, Z
AU  - Sood, R
AU  - Kastner, D L
Y1  - 1998/07//1998 Jul
N1  - Accession Number: 104798586. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Autoimmune Diseases -- Epidemiology
KW  - Autoimmune Diseases
KW  - Adult
KW  - Amino Acids
KW  - Amyloidosis -- Complications
KW  - Child, Preschool
KW  - Genetic Techniques
KW  - Colchicine -- Adverse Effects
KW  - DNA
KW  - Diagnosis, Differential
KW  - Autoimmune Diseases -- Complications
KW  - Autoimmune Diseases -- Drug Therapy
KW  - Female
KW  - Genotype
KW  - Gout Suppressants -- Adverse Effects
KW  - Surveys
KW  - Human
KW  - Kidney Diseases -- Complications
KW  - Male
KW  - Middle Age
KW  - National Institutes of Health (U.S.)
KW  - Mutation
KW  - Referral and Consultation
KW  - Severity of Illness Indices
KW  - United States
SP  - 268
EP  - 297
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 77
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Regarded as the most common and best understood of the hereditary periodic fever syndromes, familial Mediterranean fever (FMF) is a recessively inherited disease of episodic fever with some combination of severe abdominal pain, pleurisy, arthritis, and a characteristic ankle rash. The flares typically last for up to 3 days at a time, and most patients are completely asymptomatic between attacks; if untreated with prophylactic colchicine, some patients later develop amyloidosis and renal failure. The recent cloning of the FMF gene on the short arm of chromosome 16p, and the subsequent finding that its tissue expression is limited to granulocytes, has helped to explain the dramatic accumulation of neutrophils at the symptomatic serosal sites; the wild-type gene likely acts as an upregulator of an anti-inflammatory molecule or as a downregulator of a pro-inflammatory molecule. For nearly half a century, FMF was thought to cluster primarily in non-Ashkenazi Jews, Arabs, Armenians, and Turks, although the screening of the 8 known mutations in an American cohort has identified substantial numbers of people from the Ashkenazi Jewish and Italian populations in the United States who also have this disease. Nevertheless, the symptoms often go unrecognized and patients remain undiagnosed for years, not receiving the highly efficacious colchicine therapy; their histories often include multiple laparotomies, laparoscopies, and psychiatric evaluations. The combinations of clinical manifestations among FMF patients are quite heterogeneous, but our American cohort did not establish any connections between individual mutations and specific clinical pictures--as is seen in other diseases like cystic fibrosis, in which distinct genotypes target certain organ systems. Specifically, the data from our American series are insufficient to evaluate the hypothesis that the M694V/M694V genotype confers a more severe phenotype, or increases the risk of amyloidosis; but both our data and the recent literature (160) indicate that amyloidosis can occur in FMF patients with only 1 copy, or no copies, of the M694V mutation. It appears that specific MEFV mutations are probably not the sole determinants of phenotype, and that unknown environmental factors or modifying genes act as accomplices in this disease. Although we hope the discovery of the FMF gene will allow the diagnosis of FMF to become genetically accurate, the reality is that both clinical and genetic tools must still be used together unless mutations are identified on both of a patient's chromosomes. Physicians should be careful not to rule out the diagnosis in patients of high-risk ethnic backgrounds just because of atypical clinical features, as our data indicate that MEFV mutations are sometimes demonstrable in such patients. At the same time, physicians cannot yet rely solely on a genetic diagnosis because we have not yet identified a sufficient spectrum of mutations, and it is not currently feasible to examine every patient's full DNA sequence for the entire gene; screening an ethnically consistent and clinically positive patient for the 8 known mutations frequently identifies a mutation on only 1 chromosome, and genetic analysis of other classic cases will often reveal none of the 8 mutations. Still, our data suggest that ethnic background is an important predictor of finding 1 of the presently known mutations, and the knowledge of ancestries atypical for FMF can suggest the diagnosis of other hereditary periodic fever syndromes. As the list of FMF-associated MEFV mutations is expanded, and/or new sequencing technologies permit more rapid screening, the value and interpretation of genetic testing for FMF will become more straightforward. Moreover, as the pathophysiology of this disorder becomes less of a hypothesis and more of an understood entity, it is likely that treatment options will broaden beyond the use of daily prophylactic colchicine. (ABSTRACT TRUNCATED)
SN  - 0025-7974
AD  - Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1820, USA.
U2  - PMID: 9715731.
DO  - 10.1097/00005792-199807000-00005
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104798586&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bewley, Carole A.
AU  - Gustafson, Kirk R.
AU  - Boyd, Michael R.
AU  - Covell, David G.
AU  - Bax, Ad
AU  - Clore, G. Marius
AU  - Gronenborn, Angela M.
T1  - Solution structure of cyanovirin-N, a potent HIV-inactivating protein.
JO  - Nature Structural Biology
JF  - Nature Structural Biology
Y1  - 1998/07//
VL  - 5
IS  - 7
M3  - Article
SP  - 571
EP  - 578
PB  - Nature Publishing Group
SN  - 10728368
AB  - The solution structure of cyanovirin-N, a potent 11,000 Mr HIV-inactivating protein that binds with high affinity and specificity to the HIV surface envelope protein gp120, has been solved by nuclear magnetic resonance spectroscopy, including extensive use of dipolar couplings which provide a priori long range structural information. Cyanovirin-N is an elongated, largely β-sheet protein that displays internal two-fold pseudosymmetry. The two sequence repeats (residues 1?50 and 51?101) share 32% sequence identity and superimpose with a backbone atomic root-mean-square difference of 1.3 Å. The two repeats, however, do not form separate domains since the overall fold is dependent on numerous contacts between them. Rather, two symmetrically related domains are formed by strand exchange between the two repeats. Analysis of surface hydrophobic clusters suggests the location of potential binding sites for protein?protein interactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Nature Structural Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - HIV infections
KW  - HYDROPHOBIC surfaces
KW  - ANTIVIRAL agents
KW  - ANTI-infective agents
KW  - DRUGS
N1  - Accession Number: 11352012; Bewley, Carole A. 1 Gustafson, Kirk R. 2 Boyd, Michael R. 2 Covell, David G. 3 Bax, Ad 1 Clore, G. Marius 1 Gronenborn, Angela M. 1; Affiliation:  1: Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA.  2: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.  3: Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, Maryland 21702-1201, USA.; Source Info: Jul98, Vol. 5 Issue 7, p571; Subject Term: PROTEINS; Subject Term: HIV infections; Subject Term: HYDROPHOBIC surfaces; Subject Term: ANTIVIRAL agents; Subject Term: ANTI-infective agents; Subject Term: DRUGS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3  - 10.1038/828
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107286367
T1  - Fatigue in HIV-infected men receiving investigational interleukin-2.
AU  - Grady C
AU  - Anderson R
AU  - Chase GA
Y1  - 1998/07//1998 Jul-Aug
N1  - Accession Number: 107286367. Language: English. Entry Date: 19981001. Revision Date: 20150818. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Piper Fatigue Scale (PFS); St. Mary's Hospital Sleep Questionnaire (Ellis et al). Grant Information: Supported by the Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health (NIH). NLM UID: 0376404. 
KW  - Fatigue
KW  - HIV-Infected Patients
KW  - Interleukin 2 -- Therapeutic Use
KW  - Interleukin 2 -- Adverse Effects
KW  - HIV Infections -- Drug Therapy
KW  - Clinical Trials
KW  - Funding Source
KW  - Prospective Studies
KW  - Observational Methods
KW  - Convenience Sample
KW  - Research Instruments
KW  - Repeated Measures
KW  - Analysis of Variance
KW  - Linear Regression
KW  - Descriptive Statistics
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Human
SP  - 227
EP  - 234
JO  - Nursing Research
JF  - Nursing Research
JA  - NURS RES
VL  - 47
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - BACKGROUND: Although fatigue is an almost universal clinical complaint of people with human immunodeficiency virus (HIV) infection, little has been done to study systematically the etiology, frequency, severity, response to, or management of HIV-related fatigue. In addition, HIV-related treatments may contribute to fatigue. OBJECTIVES: To describe the extent and severity of perceived fatigue in a cohort of HIV-infected men (N= 50) who, as participants in a randomized clinical trial, were randomized to receive or not to receive investigational interleukin-2 (IL-2). METHOD: A modified Piper Fatigue Scale was used to measure fatigue at baseline, at the end of 5 days of IL-2 therapy, 1 week later at home, and 1 month later for three consecutive cycles of IL-2 therapy. RESULTS: Against a variable background of baseline fatigue in all subjects, those receiving IL-2 reported a significant increase in their level of fatigue after receiving IL-2. Fatigue levels remained elevated 1 week later but returned to baseline by 1 month. Fatigue was related to the dose of IL-2 but not to the reported amount or quality of sleep. CONCLUSIONS: Against a background of fatigue related to HIV infection and its multiple manifestations and treatments, therapy with IL-2 dramatically increases the experience of fatigue. Although this increase is transient and tends to return to baseline by 1 month, during that month the patient's life function and quality may be severely affected.
SN  - 0029-6562
AD  - Dept of Clinical Bioethics, WG Magnuson Clinical Center, Bldg 10/Room 1C118, National Institutes of Health, Bethesda, MD 20892; e-mail: christine_grady@nih.gov
U2  - PMID: 9683118.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107284583
T1  - Research briefs. Reinfusion of discard blood from venous access devices.
AU  - Cosca PA
AU  - Smith S
AU  - Chatfield S
AU  - Meleason A
AU  - Muir CA
AU  - Nerantzis S
AU  - Petrofsky M
AU  - Williams S
Y1  - 1998/07//1998 Jul
N1  - Accession Number: 107284583. Language: English. Entry Date: 19981001. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Vascular Access Devices
KW  - Blood Coagulation
KW  - Blood Specimen Collection
KW  - Pretest-Posttest Design
KW  - Cancer Patients
KW  - Descriptive Statistics
KW  - Convenience Sample
KW  - Comparative Studies
KW  - Syringes
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1073
EP  - 1076
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 25
IS  - 6
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - PURPOSE/OBJECTIVES: To determine if clots are present in the initial 10 ml of blood routinely discarded from venous access devices (VADs) prior to blood sampling, and to determine if clots form in the discard blood specimen during the five minutes required to complete blood specimen sampling. DESIGN: A pretest/post-test design. SETTING: A large, mid-Atlantic research institution. SAMPLE: A convenience sample of 50 adult patients with cancer (27 males and 23 females) with a median age of 60. A large sampling size variation existed among the different VADs. METHOD: Two 5 ml discard specimens were drawn into separate syringes. Syringe #1 was filtered immediately, and syringe #2 was filtered after a five-minute dwell time. Both samples were filtered through a 40 micron filter. MAIN RESEARCH VARIABLE: The presence or absence of clots. FINDINGS: Fifty percent (n = 25) of the VADs had clots present on the filter from syringe #1. The clots varied in length, width, depth, and diameter, which precluded a consistent measurement. The investigators were able to measure either the diameter or length, depending on the shape of the clots. The majority of the clots (n = 17) appeared to be shaped like the lumen of a catheter and varied from 0.1 cm to 1.2 cm in length. Six clots were round and varied in diameter from 1.6 mm to 2.8 mm. Only 4% (n = 2) of the VADs had clots in syringe #2, but those clots were much larger, measuring 8.3 mm and 18.4 mm. CONCLUSIONS: The study addresses concerns of the investigators regarding the clinical practice of reinfusing discard blood obtained from VADs. Whether the clots present in the catheter and their reinfusion represent a significant risk to patient outcome is unclear. IMPLICATIONS FOR NURSING PRACTICE: Until further research is conducted and the degree of risk can be better defined, methods of drawing blood that require reinfusion of discard blood from VADs are not recommended.
SN  - 0190-535X
AD  - National Institutes of Health, National Cancer Institute, Bethesda, MD
U2  - PMID: 9679265.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107166890
T1  - Rural psychiatry in developing countries...based on presentations given at a symposium on rural psychiatry held on March 14, 1997... at Mercer University School of Medicine in Macon, Georgia
AU  - Murthy RS
Y1  - 1998/07//
N1  - Accession Number: 107166890. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838. 
KW  - Rural Health Services -- Developing Countries
KW  - Mental Health Services -- Developing Countries
KW  - Developing Countries
KW  - India
SP  - 967
EP  - 969
JO  - Psychiatric Services
JF  - Psychiatric Services
JA  - PSYCHIATR SERV
VL  - 49
IS  - 7
CY  - Arlington, Virginia
PB  - American Psychiatric Publishing, Inc.
AB  - During the last two decades several initiatives have been taken to improve psychiatric services in low-income rural areas in developing countries. They have included the formulation of national mental health programs and establishment of pilot programs for integration of mental health care with primary health care in India, Iran, and other countries in Asia, Africa, and South America. The psychiatrist has multiple roles to play in meeting the many challenges of providing mental health care in rural areas in developing countries.
SN  - 1075-2730
AD  - National Institute of Mental Health and Neuro Sciences, PO Box 2900, Bangalore 560 029, India. E-mail: rsm@nimhans.ren.nic.in
U2  - PMID: 9661237.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107289037
T1  - Epidemiology: second-rate science.
AU  - Parascandola M
Y1  - 1998/07//Jul/Aug98
N1  - Accession Number: 107289037. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844. 
KW  - Epidemiology -- Evaluation
KW  - Social Attitudes
KW  - Epidemiological Research -- History
KW  - Observational Methods -- Utilization
KW  - Smoking -- Epidemiology
KW  - Epidemiological Research -- Utilization
KW  - Science -- History
KW  - Research, Medical
KW  - Scientists -- History
KW  - Public Health -- Trends
KW  - Experimental Studies
SP  - 312
EP  - 320
JO  - Public Health Reports
JF  - Public Health Reports
JA  - PUBLIC HEALTH REP
VL  - 113
IS  - 4
PB  - Sage Publications Inc.
AB  - In recent years epidemiology has come under increasing criticism in regulatory and public arenas for being 'unscientific.' The tobacco industry has taken advantage of this, insisting for decades that evidence linking cigarettes and lung cancer falls short of proof. Moreover, many epidemiologists remain unduly skeptical and self-conscious about the status of their own, causal, claims. This situation persists in part because of a widespread belief that only the laboratory can provide evidence sufficient for scientific proof. Adherents of this view erroneously believe, that there is no element of uncertainty or inductive inference in the 'direct observation' of the laboratory researcher and that epidemiology provides, mere 'circumstantial' evidence. The historical roots of this attitude can be traced to philosopher John Stuart Mill and physiologist Claude Bernard and their influence on modern experimental thinking. The author uses the debate over cigarettes and lung cancer to examine ideas of proof in medical science and public health, concluding that inductive inference from a limited sample to a larger population is an element in all empirical science.
SN  - 0033-3549
AD  - National Institutes of Health Historical Office, Bldg. 31, Rm. 2B09, National Institutes of Health, Bethesda, MD 20892. E-mail: mparas@erols.com
U2  - PMID: 9672568.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107284942
T1  - Intractable wheezing due to an obstructing tracheal neuroendocrine tumor in an adolescent with HIV infection.
AU  - Ludlam SE
AU  - Zeidman D
AU  - Wood LV
AU  - Ognibene FP
Y1  - 1998/07//1998 Jul
N1  - Accession Number: 107284942. Language: English. Entry Date: 19981001. Revision Date: 20150819. Publication Type: Journal Article; case study; diagnostic images. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7510357. 
KW  - Childhood Neoplasms
KW  - HIV Infections -- Complications -- In Adolescence
KW  - Airway Obstruction -- Etiology -- In Adolescence
KW  - Respiratory Sounds
KW  - Tomography, X-Ray Computed
KW  - Diagnosis, Differential
KW  - Radiotherapy
KW  - Tracheal Diseases -- Diagnosis -- In Adolescence
KW  - Adolescence
KW  - Male
SP  - 562
EP  - 566
JO  - Respiratory Care
JF  - Respiratory Care
JA  - RESPIR CARE
VL  - 43
IS  - 7
CY  - Irving, Texas
PB  - Daedalus Enterprises, Inc.
AB  - We describe a 13-year-old boy with human immunodeficiency virus (HIV) infection who presented with wheezing, fever, and dyspnea. Because he had a history of wheezing with a previous episode of viral pneumonia, he underwent diagnostic procedures for possible pulmonary infections and was treated for exacerbation of reactive airway disease. When he failed to respond to aggressive anti-inflammatory and bronchodilator therapy, further workup revealed an endobronchial neuroendocrine tumor occluding 75% of the trachea at the level of the carina. We describe our patient's treatment and review the literature on endobronchial lesions in HIV-infected patients.
SN  - 0020-1324
AD  - Critical Care Medicine Department, Warren G Magnuson Clinical Center of the National Institutes of Health and the HIV/AIDS Malignancy Branch of the Division of Clinical Sciences of the National Cancer Institute, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Leibenluft, Ellen
T1  - Why Are So Many Women Depressed?
JO  - Scientific American Presents
JF  - Scientific American Presents
Y1  - 1998/07//
M3  - Article
SP  - 30
EP  - 35
PB  - Scientific American
SN  - 15240223
AB  - This article focuses on the depression in women. In 1990 the World Health Organization found depression to be the leading cause of disease burden among women, noting that it affects almost 20 percent of the female population in the developed world. Epidemiological studies indicate that 12 percent of U.S. women compared with only 6 percent of U.S. men have suffered from clinically significant depression at some time in their lives. Some mental health workers have pointed to psychology, arguing that women are better trained to recognize their feelings and seek help, so they come to the attention of health professionals more often than men.
KW  - WOMEN -- Mental health
KW  - WOMEN -- Psychology
KW  - WOMEN -- Diseases
KW  - EPIDEMIOLOGY
KW  - UNITED States
KW  - WORLD Health Organization
N1  - Accession Number: 20921295; Leibenluft, Ellen 1; Affiliation:  1: Chief of the Unit on Rapid Cycling Bipolar Disorder within the Clinical Psychobiology Branch at the National Institute of Mental Health.; Source Info: 1998, p30; Subject Term: WOMEN -- Mental health; Subject Term: WOMEN -- Psychology; Subject Term: WOMEN -- Diseases; Subject Term: EPIDEMIOLOGY; Subject Term: UNITED States; Company/Entity: WORLD Health Organization; Number of Pages: 6p; Illustrations: 3 Color Photographs; Document Type: Article; Full Text Word Count: 3168
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shields, Peter G.
AU  - Ambrosone, Christine B.
T1  - Smoking and Breast Cncer.
JO  - Scientific American Presents
JF  - Scientific American Presents
Y1  - 1998/07//
M3  - Article
SP  - 86
EP  - 89
PB  - Scientific American
SN  - 15240223
AB  - The article focuses on the link between smoking and breast cancer. Researchers believe that one important and preventable risk factor for breast cancer is cigarette smoking. New studies suggest that roughly half of all women are particularly sensitive to the carcinogens found in tobacco and so have a higher risk of breast cancer if they smoke cigarettes. Such women have a slow-acting form of a liver enzyme that normally detoxifies carcinogens. Because these women's "detox" enzymes act more slowly than the enzymes of other women, the carcinogens in tobacco last longer in their bodies, allowing the substances more time to cause cancer.  INSET: Lung Cancer: Why Women's Risks Are Higher.
KW  - BREAST cancer
KW  - SMOKING
KW  - CIGARETTE smokers
KW  - CARCINOGENS
KW  - CANCER in women
KW  - WOMEN -- Health
N1  - Accession Number: 20921316; Shields, Peter G. 1 Ambrosone, Christine B. 2; Affiliation:  1: Chief of the Molecular Epidemiology Section in the Laboratory of Human Carcinogenesis at the National Cancer Institute  2: Research epidemiologist in the Division of Molecular Epidemiology at the Food and Drug Administration's National Center for Toxicological Research in Jefferson, Ark; Source Info: 1998, p86; Subject Term: BREAST cancer; Subject Term: SMOKING; Subject Term: CIGARETTE smokers; Subject Term: CARCINOGENS; Subject Term: CANCER in women; Subject Term: WOMEN -- Health; Number of Pages: 4p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 2774
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mathews, James M.
AU  - Etheridge, Amy S.
AU  - Matthews, H. B.
T1  - HIGHLIGHT.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/07//
VL  - 44
IS  - 1
M3  - Article
SP  - 14
EP  - 21
SN  - 10966080
AB  - The disposition of oral doses of [14C]benzene was investigated using a range of doses that included lower levels (0.02 and 0.1 mg/kg) than have been studied previously in rat, mouse, and in hamster, a species which has not been previously examined for its capacity to metabolize benzene. Saturation of metabolism of benzene was apparent as the dose increased, and a considerable percentage of the highest doses (100 mg/kg) was exhaled unchanged. Most of the remainder of the radioactivity was excreted as metabolites in urine, and significant metabolite-specific changes occurred as a function of dose and species. Phenyl sulfate was the predominant metabolite in rat urine at all dose levels (64–73%) of urinary radioactivity), followed by prephenylmercapturic acid (10–11%). Phenyl sulfate (24–32%) and hydroquinone glucuronide (27–29%) were the predominant metabolites formed by mice. Mice produced considerably more muconic add (15%), which is derived from the toxic metabolite muconaldehyde, than did rats (7%) at a dose of 0.1 mg/kg. Unlike both rats and mice, hydroquinone glucuronide (24–29%) and muconic acid (19–31%) were the primary urinary metabolites formed by hamsters. Two metabolites not previously detected in the urine of rats or mice after single doses, 1,2,4-trihydroxybenzene and catechol sulfate, were found in hamster urine. These data indicate that hamsters metabolize benzene to more highly oxidized, toxic products than do rats or mice. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83181081; Mathews, James M. 1; Etheridge, Amy S. 1; Matthews, H. B. 2; Affiliations: 1: Center for Bioorganic Chemistry. Research Triangle Institute P.O. Box 12194, Research Triangle Park, North Carolina 27709; 2: National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709; Issue Info: 1998, Vol. 44 Issue 1, p14; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-41725-011
AN  - 2015-41725-011
AU  - Zuo, Jian
AU  - Ferguson, Toby A.
AU  - Hernandez, Yosbani J.
AU  - Stetler-Stevenson, William G.
AU  - Muir, David
T1  - Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/07//
VL  - 18
IS  - 14
SP  - 5203
EP  - 5211
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Muir, David, University of Florida College of Medicine, Box 100296, Gainesville, FL, US, 32610
N1  - Accession Number: 2015-41725-011. PMID: 9651203 Partial author list: First Author & Affiliation: Zuo, Jian; Department of Pediatrics, Neurology Division, University of Florida Brain Institute, Gainesville, FL, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Muir, David. Major Descriptor: Basal Ganglia; Neurons; Astrocytes; Neural Regeneration. Minor Descriptor: Schwann Cells. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: Jul, 1998. Publication History: Accepted Date: Apr 30, 1998; First Submitted Date: Apr 8, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Chondroitin sulfate proteoglycans (CSPGs) are implicated in the regulation of axonal growth. We previously reported that the neurite-promoting activity of laminin is inhibited by association with a Schwann cell-derived CSPG and that endoneurial laminin may be inhibited by this CSPG as well [Zuo J, Hernandez YJ, Muir D (1998) Chondroitin sulfate proteoglycan with neurite-inhibiting activity is upregulated after peripheral nerve injury. J Neurobiol 34:41–54]. Mechanisms regulating axonal growth were studied by using an in vitro bioassay in which regenerating embryonic dorsal root ganglionic neurons (DRGn) were grown on sections of normal adult nerve. DRGn achieved slow neuritic growth on sections of normal nerve, which was reduced significantly by treatment with metalloproteinase inhibitors. Similar results were obtained on a synthetic substratum composed of laminin and inhibitory CSPG. DRGn expressed the matrix metalloproteinase, MMP-2, which was transported to the growth cone. Recombinant MMP-2 inactivated the neurite-inhibiting CSPG without hindering the neurite-promoting potential of laminin. Similarly, neuritic growth by DRGn cultured on normal nerve sections was increased markedly by first treating the nerve sections with MMP-2. The proteolytic deinhibition by MMP-2 was equivalent to and nonadditive with that achieved by chondroitinase, suggesting that both enzymes inactivated inhibitory CSPG. Additionally, the increases in neuritic growth resulting from treating nerve sections with MMP-2 or chondroitinase were blocked by anti-laminin antibodies. From these results we conclude that MMP-2 provides a mechanism for the deinhibition of laminin in the endoneurial basal lamina and may play an important role in the regeneration of peripheral nerve. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - chondroitin sulfate proteoglycan
KW  - matrix metalloproteinase
KW  - neuronal regeneration
KW  - neurite inhibitor
KW  - basal lamina
KW  - peripheral nerve
KW  - laminin
KW  - cryoculture
KW  - 1998
KW  - Basal Ganglia
KW  - Neurons
KW  - Astrocytes
KW  - Neural Regeneration
KW  - Schwann Cells
KW  - 1998
U1  - Sponsor: National Institutes of Health, US. Grant: NS31255. Recipients: Muir, David
U1  - Sponsor: Florida State Brain and Spinal Cord Injury Rehabilitation Trust Fund, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41725-040
AN  - 2015-41725-040
AU  - Zhao, Hui-Min
AU  - Wenthold, Robert J.
AU  - Petralia, Ronald S.
T1  - Glutamate receptor targeting to synaptic populations on Purkinje cells is developmentally regulated.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/07//
VL  - 18
IS  - 14
SP  - 5517
EP  - 5528
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Petralia, Ronald S., National Institute on Deafness and Other Communication Disorders, 36/5D08, 36 Convent Drive, MSC 4162, Bethesda, MD, US, 20892-4162
N1  - Accession Number: 2015-41725-040. PMID: 9651232 Partial author list: First Author & Affiliation: Zhao, Hui-Min; National Institute on Deafness and Other Communication Disorders, Bethesda, MD, US. Release Date: 20160905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neural Receptors; Neurons; Neurotransmitters; AMPA. Minor Descriptor: Brain; Purkinje Cells; Synapses. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Jul, 1998. Publication History: Accepted Date: Apr 30, 1998; Revised Date: Apr 29, 1998; First Submitted Date: Feb 26, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Selective targeting of neurotransmitter receptors to specific synapse populations occurs in adult neurons, but little is known about the development of these receptor distribution patterns. In this study, we demonstrate that a specific developmental switch occurs in the targeting of a receptor to an identified synapse population. Localization of delta and AMPA glutamate receptors at parallel and climbing fiber synapses on the developing Purkinje cells was studied using postembedding immunogold. Delta receptors were found to be abundant on postsynaptic membranes at parallel fiber synapses from postnatal day 10 (P10) to adult. In contrast, delta receptors were found to be high at climbing fiber synapses only at P10 and P14. Thus, a major finding of this paper is that high levels of delta receptors are transiently expressed in climbing fiber synapses in the second postnatal week. Labeling of synapses with anti-delta receptor antibody at P10 was limited to the postsynaptic membrane of excitatory synapses and was absent from GABAergic synapses. Unlike delta receptor immunolabeling, AMPA receptor immunolabeling (GluR2/3 and GluR2 antibodies) was high in the postsynaptic membranes of synapses at early postnatal ages (P2 and P5) and was higher in climbing fiber synapses than in parallel fiber synapses from P10 to adult. The present study shows that synapse-specific targeting of glutamate receptors in Purkinje cells is developmentally regulated, with the postsynaptic receptor composition established during synapse maturation. This composition is not dependent on the nature of the initial establishment of synaptic connections. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - AMPA
KW  - cerebellum
KW  - climbing fiber
KW  - delta
KW  - parallel fiber
KW  - synaptogenesis
KW  - 1998
KW  - Neural Receptors
KW  - Neurons
KW  - Neurotransmitters
KW  - AMPA
KW  - Brain
KW  - Purkinje Cells
KW  - Synapses
KW  - 1998
U1  - Sponsor: National Institute on Deafness and Other Communication Disorders, Intramural Research Program, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107291134
T1  - AIDS: a role for host genes.
AU  - O'Brien SJ
Y1  - 1998/07/15/
N1  - Accession Number: 107291134. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8404149. 
KW  - Acquired Immunodeficiency Syndrome -- Familial and Genetic
KW  - Human Immunodeficiency Virus -- Physiology
KW  - Disease Susceptibility -- Familial and Genetic
KW  - Disease Progression -- Familial and Genetic
KW  - Mutation
KW  - Genes
KW  - Education, Continuing (Credit)
KW  - Genetics, Medical
KW  - Research, Medical
KW  - Receptors, Cell Surface
KW  - Cytokines -- Physiology
KW  - T Lymphocytes -- Physiology
KW  - Genetic Techniques
KW  - Ethnic Groups
KW  - Animal Studies
KW  - Mice
SP  - 53
EP  - 67
JO  - Hospital Practice
JF  - Hospital Practice
JA  - HOSP PRACT
VL  - 33
IS  - 7
CY  - East Windsor, New Jersey
PB  - S&P Global, Inc
SN  - 8750-2836
AD  - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD
U2  - PMID: 9679506.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hatch, Christopher L.
AU  - Goodman, Steven N.
AU  - Hatch, C L
AU  - Goodman, S N
T1  - Perceived value of providing peer reviewers with abstracts and preprints of related published and unpublished papers.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1998/07/15/
VL  - 280
IS  - 3
M3  - journal article
SP  - 273
EP  - 274
SN  - 00987484
AB  - <bold>Context: </bold>Many journals provide peer reviewers with written instructions regarding review criteria, such as the originality of results, but little research has been done to investigate ways to improve or facilitate the peer review task.<bold>Objective: </bold>To assess the value that peer reviewers place on receipt of supplemental materials (eg, abstracts of related papers and preprints of related unpublished manuscripts).<bold>Design: </bold>Questionnaire survey sent to all 733 peer reviewers recruited by the Journal of the National Cancer Institute to review 356 manuscripts consecutively sent out for review from February 24, 1997, through January 16, 1998. The inclusion of supplemental materials with manuscript review packages was optional.<bold>Main Outcome Measure: </bold>The peer reviewers' assessment of the actual or potential usefulness of supplemental materials on the performance of peer review.<bold>Results: </bold>A total of 481 (66%) of 733 questionnaires were returned. Of the 471 respondents' questionnaires that could be used, 217 (46%) indicated that they received abstracts, and 44 (10%) of 458 respondents indicated that they received preprints. Higher proportions of peer reviewers who received supplemental materials than those who had not received them felt that they were (or would be) useful to them when reviewing the manuscript (63% [95% confidence interval (CI), 57%-69%] vs 45% [95% CI, 38%-52%]; P<.001) and to the peer review process in general (80% [95% CI, 75%-85%] vs 64% [95% CI, 58%-70%]; P<.001).<bold>Conclusion: </bold>The majority of respondents indicated that supplemental materials helped (or would have helped) them evaluate manuscripts and valued them more highly when they actually received them. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEER review (Professional performance)
KW  - MEDICAL research
KW  - ABSTRACTS
N1  - Accession Number: 832012; Hatch, Christopher L. Goodman, Steven N. Hatch, C L 1 Goodman, S N; Affiliation:  1: Journal of the National Cancer Institute, Bethesda, MD, USA; Source Info: 7/15/98, Vol. 280 Issue 3, p273; Subject Term: PEER review (Professional performance); Subject Term: MEDICAL research; Subject Term: ABSTRACTS; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: journal article
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ER  - 

TY  - JOUR
AU  - Ron, Elaine
AU  - Doody, Michele Morin
AU  - Becker, David V.
AU  - Brill, A. Bertrand
AU  - Curtis, Rochelle E.
AU  - Goldman, Marlene B.
AU  - Harris III, Benjamin S.H.
AU  - Hoffman, Daniel A.
AU  - McConahey, William M.
AU  - Maxon, Harry R.
AU  - Preston-Martin, Susan
AU  - Warshauer, M. Ellen
AU  - Wong, F. Lennie
AU  - Boice, John D.
AU  - Ron, E
AU  - Doody, M M
AU  - Becker, D V
AU  - Brill, A B
AU  - Curtis, R E
AU  - Goldman, M B
T1  - Cancer mortality following treatment for adult hyperthyroidism. Cooperative Thyrotoxicosis Therapy Follow-up Study Group.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1998/07/22/
VL  - 280
IS  - 4
M3  - journal article
SP  - 347
EP  - 355
SN  - 00987484
AB  - <bold>Context: </bold>High-dose iodine 131 is the treatment of choice in the United States for most adults with hyperthyroid disease. Although there is little evidence to link therapeutic (131)I to the development of cancer, its extensive medical use indicates the need for additional evaluation.<bold>Objective: </bold>To evaluate cancer mortality among hyperthyroid patients, particularly after (131)I treatment.<bold>Design: </bold>A retrospective cohort study.<bold>Setting: </bold>Twenty-five clinics in the United States and 1 clinic in England.<bold>Patients: </bold>A total of 35 593 hyperthyroid patients treated between 1946 and 1964 in the original Cooperative Thyrotoxicosis Therapy Follow-up Study; 91 % had Graves disease, 79% were female, and 65% were treated with (131)I.<bold>Main Outcome Measure: </bold>Standardized cancer mortality ratios (SMRs) after 3 treatment modalities for hyperthyroidism.<bold>Results: </bold>Of the study cohort, 50.5% had died by the end of follow-up in December 1990. The total number of cancer deaths was close to that expected based on mortality rates in the general population (2950 vs 2857.6), but there was a small excess of mortality from cancers of the lung, breast, kidney, and thyroid, and a deficit of deaths from cancers of the uterus and the prostate gland. Patients with toxic nodular goiter had an SMR of 1.16 (95% confidence interval [CI], 1.03-1.30). More than 1 year after treatment, an increased risk of cancer mortality was seen among patients treated exclusively with antithyroid drugs (SMR, 1.31; 95% CI, 1.06-1.60). Radioactive iodine was not linked to total cancer deaths (SMR, 1.02; 95% CI, 0.98-1.07) or to any specific cancer with the exception of thyroid cancer (SMR, 3.94; 95% CI, 2.52-5.86).<bold>Conclusions: </bold>Neither hyperthyroidism nor (131)I treatment resulted in a significantly increased risk of total cancer mortality. While there was an elevated risk of thyroid cancer mortality following (131)I treatment, in absolute terms the excess number of deaths was small, and the underlying thyroid disease appeared to play a role. Overall, (131)I appears to be a safe therapy for hyperthyroidism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYPERTHYROIDISM -- Treatment
KW  - PATIENTS
KW  - CANCER -- Mortality
KW  - MORTALITY
N1  - Accession Number: 863054; Ron, Elaine Doody, Michele Morin Becker, David V. Brill, A. Bertrand Curtis, Rochelle E. Goldman, Marlene B. Harris III, Benjamin S.H. Hoffman, Daniel A. McConahey, William M. Maxon, Harry R. Preston-Martin, Susan Warshauer, M. Ellen Wong, F. Lennie Boice, John D. Ron, E 1 Doody, M M Becker, D V Brill, A B Curtis, R E Goldman, M B; Affiliation:  1: Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 7/22/98-7/29/98, Vol. 280 Issue 4, p347; Subject Term: HYPERTHYROIDISM -- Treatment; Subject Term: PATIENTS; Subject Term: CANCER -- Mortality; Subject Term: MORTALITY; Number of Pages: 9p; Illustrations: 1 Diagram, 9 Charts; Document Type: journal article
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ER  - 

TY  - JOUR
ID  - 107278312
T1  - Factors associated with the transition to nonprone sleep positions of infants in the United States: the National Infant Sleep Position Study.
AU  - Willinger M
AU  - Hoffman HJ
AU  - Wu K
AU  - Hou J
AU  - Kessler RC
AU  - Ward SL
AU  - Keens TG
AU  - Corwin MJ
AU  - Willinger, M
AU  - Hoffman, H J
AU  - Wu, K T
AU  - Hou, J R
AU  - Kessler, R C
AU  - Ward, S L
AU  - Keens, T G
AU  - Corwin, M J
Y1  - 1998/07/22/
N1  - Accession Number: 107278312. Language: English. Entry Date: 19980801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Supplement Title: 7/22/98-7/29/98. Commentary: Slawson D. How many of our patients place their infants in the nonprone sleep position, and how has this affected the rate of sudden infant death syndrome (SIDS)? (EVID BASED PRACT) 1998 Oct; 1 (10): 7-insert 2p; Moy J G. Putting babies "back to sleep". (JAMA) 3/17/99; 281 (11): 983-984. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: HD-2-2996/HD/NICHD NIH HHS/United States. NLM UID: 7501160. 
KW  - Prone Position -- In Infancy and Childhood
KW  - Sleep -- In Infancy and Childhood
KW  - Infant Care
KW  - Surveys
KW  - Multiple Logistic Regression
KW  - Chi Square Test
KW  - Prone Position -- Trends
KW  - Ethnic Groups
KW  - Age Factors
KW  - Parity
KW  - Educational Status
KW  - Sudden Infant Death -- Prevention and Control
KW  - Maternal Age
KW  - Funding Source
KW  - Infant, Newborn
KW  - Infant
KW  - Adult
KW  - Adolescence
KW  - Sudden Infant Death -- Trends
KW  - Telephone
KW  - Maternal Behavior
KW  - United States
KW  - Random Sample
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Human
SP  - 329
EP  - 335
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 280
IS  - 4
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Studies have demonstrated strong associations between the prone sleep position (on the stomach) and sudden infant death syndrome (SIDS). In 1992, the American Academy of Pediatrics recommended that infants be placed to sleep laterally (on their side) or supine (on their back) to reduce SIDS risk, and in 1994, the national public education campaign "Back to Sleep" was launched.Objective: To determine the typical sleep position of infants younger than 8 months in the United States, the changes that occurred after these recommendations, and the factors associated with the placement of infants prone or supine.Design: Annual nationally representative telephone surveys.Setting: The 48 contiguous states of the United States.Participants: Nighttime caregivers of infants born within the last 7 months between 1992 and 1996. Approximately 1000 interviews were conducted per year.Main Outcome Measures: The position the infant was usually placed in for sleep, and the position the infant was most commonly found in when checked during the night's sleep.Results: Ninety-seven percent of respondents in each wave of the survey usually placed their infant to sleep in a specific position. Infants were placed in the prone position by 70% of caregivers in 1992, prior to the campaign, but only 24% in 1996. Supine and lateral placements increased during this time period, from 13% in 1992 to 35% in 1996 and from 15% in 1992 to 39% in 1996, respectively. Significant predictors of prone placement included maternal race reported as black (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.68-3.26), mother's age 20 to 29 years (OR, 1.28; 95% CI, 1.09-1.50), region reported as the mid-Atlantic (OR, 1.41; 95% CI, 1.12-1.78) or southern states (OR, 1.47; 95% CI, 1.22-1.70), mothers with a previous child (OR, 1.68; 95% CI, 1.43-1.97), and infants younger than 8 weeks (OR, 0.63; 95% CI, 0.46-0.85). Infants aged 8 to 15 weeks were significantly more likely to be placed nonprone over time compared with the other age groups. Most of the risk factors for prone were significantly related in the opposite direction to supine placement.Conclusions: The prevalence of infants placed in the prone sleep position declined by 66% between 1992 and 1996. Although causality cannot be proved, SIDS rates declined approximately 38% during this period. To achieve further reduction in prone sleeping, efforts to promote the supine sleep position should be aimed at groups at high risk for prone placement.
SN  - 0098-7484
AD  - Pregnancy and Perinatology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA
AD  - National Institute of Child Health and Human Development, Center for Research for Mothers and Children, Pregnancy and Perinatology Branch, Executive Bldg. Room 4B03, 6100 Executive Blvd, MSC 7510, Bethesda, MD 20892-7510. E-mail: mw75q@nih.gov
U2  - PMID: 9686549.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107278319
T1  - Prevalence and predictors of the prone sleep position among inner-city infants.
AU  - Brenner RA
AU  - Simons-Morton BG
AU  - Bhaskar B
AU  - Mehta N
AU  - Melnick VL
AU  - Revenis M
AU  - Berendes HW
AU  - Clemens JD
AU  - Brenner, R A
AU  - Simons-Morton, B G
AU  - Bhaskar, B
AU  - Mehta, N
AU  - Melnick, V L
AU  - Revenis, M
AU  - Berendes, H W
AU  - Clemens, J D
Y1  - 1998/07/22/
N1  - Accession Number: 107278319. Language: English. Entry Date: 19980801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Supplement Title: 7/22/98-7/29/98. Commentary: Moy J G. Putting babies "back to sleep". (JAMA) 3/17/99; 281 (11): 983-984. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by grants U18-HD30447, U18-HD30458, U18-HD30450, U18-HD30445, U18-HD31919, U18-HD30454, and U18-HD31206 from the National Institute of Child Health and Human Development and the National Institutes of Health, Office of Research in Minority Health, Bethesda, Md. NLM UID: 7501160. 
KW  - Prone Position -- In Infancy and Childhood
KW  - Sleep -- In Infancy and Childhood
KW  - Infant Care
KW  - Infant
KW  - Infant, Newborn
KW  - District of Columbia
KW  - Interviews
KW  - Risk Factors
KW  - Sudden Infant Death
KW  - Educational Status
KW  - Marital Status
KW  - Poverty
KW  - Urban Areas
KW  - Health Education
KW  - Maternal Behavior
KW  - Supine Position -- In Infancy and Childhood
KW  - Socioeconomic Factors
KW  - Chi Square Test
KW  - Fisher's Exact Test
KW  - T-Tests
KW  - Logistic Regression
KW  - Maternal Age
KW  - Ethnic Groups
KW  - Blacks
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Funding Source
KW  - Prospective Studies
KW  - Human
SP  - 341
EP  - 346
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 280
IS  - 4
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: The prone sleep position is associated with an increased risk of sudden infant death syndrome (SIDS), but few studies have assessed factors associated with the choice of infant sleep position.Objectives: To describe infant sleep position in a cohort of infants born to predominantly low-income, inner-city mothers and to identify predictors of the prone sleep position in this population.Design: Prospective birth cohort study.Patients and Setting: Three hundred ninety-four mother-infant dyads, systematically selected from 3 District of Columbia hospitals between August 1995 and September 1996. Mothers were interviewed shortly after delivery and again at 3 to 7 months postpartum.Main Outcome Measures: Position in which infants were placed for sleep on the night prior to the 3- to 7-month interview.Results: At 3 to 7 months of age, 157 infants (40%) were placed for sleep in the prone position. Independent predictors of prone sleep position included poverty (odds ratio [OR], 1.81; 95% confidence interval [CI], 1.10-2.99), black race (OR, 2.06; 95% CI, 1.05-4.04), presence of infant's grandmother in the home (OR, 1.83; 95% CI, 1.11-3.00), and intent, as measured shortly after delivery, to place the infant in the prone position (OR, 2.28; 95% CI, 1.44-3.60). Importantly, of the 43 mothers who observed their infants in the prone sleep position while in the hospital, 40 (93%) intended to place their infants prone at home.Conclusions: A substantial proportion of infants in this predominantly low-income population were placed in the prone sleep position. Educational efforts should address both initial intentions and reinforcement of the correct sleep position, once initiated. Hospitals should ensure that healthy newborn infants are placed in the supine sleep position during the postpartum hospital stay.
SN  - 0098-7484
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Bethesda, MD 20892. E-mail: BrennerR@nih.gov
U2  - PMID: 9686551.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107289840
T1  - Electromyography in near-total laryngectomy.
AU  - Arunodaya GR
AU  - Shenoy AM
AU  - Premalata S
Y1  - 1998/08//
N1  - Accession Number: 107289840. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts; tracings. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8603209. 
KW  - Electromyography
KW  - Laryngeal Muscles -- Physiology
KW  - Laryngectomy -- Methods
KW  - Speech -- Physiology
KW  - Adult
KW  - Aged
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Laryngeal Neoplasms -- Surgery
KW  - Treatment Outcomes -- Evaluation
KW  - Prospective Studies
KW  - P-Value
KW  - Fisher's Exact Test
KW  - Academic Medical Centers
KW  - Human
SP  - 857
EP  - 860
JO  - Archives of Otolaryngology - Head & Neck Surgery
JF  - Archives of Otolaryngology - Head & Neck Surgery
JA  - ARCH OTOLARYNGOL HEAD NECK SURG
VL  - 124
IS  - 8
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0886-4470
AD  - Department of Neurology, National Institute of Mental Health and Neurosciences
U2  - PMID: 9708709.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lamb, Michael E.
AU  - Sternberg, Kathleen J.
AU  - Esplin, Phillip W.
T1  - CONDUCTING INVESTIGATIVE INTERVIEWS OF ALLEGED SEXUAL ABUSE VICTIMS.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1998/08//
VL  - 22
IS  - 8
M3  - Article
SP  - 813
EP  - 823
SN  - 01452134
AB  - Objectives: There were two aims: First, to describe the factors that influence children's competence and second, to discuss ways in which investigative interviewers can maximize the quality and quantity of information they obtain from alleged witnesses and victims. Method: No new research is described in this paper. Rather, the authors provide a focused review of the relevant literature designed to be maximally useful for practitioners. Conclusions: Children are often the only available sources of information about possible abusive experiences. Research has shown that children can, in fact, be remarkably competent informants, although the quality and quantity of the information they provide is greatly influenced by the ways in which they are interviewed. This article describes ways in which investigative interviewers can maximize the amount and quality of information they elicit from alleged victims. (English) [ABSTRACT FROM AUTHOR]
AB  - A menudo los niños son la única fuente de información disponible en relación a las posibles experiencias de abuso. Las investigaciones han demostrado que los niños pueden, en efecto, ser informantes extremadame competentes, a pesar de que la calidad y la cantidad de la información que ellos ofrecen est' muy influenciada por las formas en que son entrevistados. En este articulo revisamos brevemente los factores que influyen en la competencia de los niños y describimos formas en las que los entrevistadores pueden maximizar la calidad de la información que obtienen de supuestos testigos y víctimas. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Les enfants sont souvent les seules sources de renseignements lorsqu'on soupçonne la maltraitance. Les recherches nous démontrent que les enfants sont fort compétents lorsqu'il s'agit de fournir des renseignements. Cependant, la qualité et la quantité de ces informations sont largement influencées par la façon dont les enfants sont interviewés. Dans cet article, nous passons en revue brièvement les facteurs qui influent sur la compétence des enfants et nous décrivons les façons dont les enquêteurs qui mènent des entrevues peuvent assurer une plus grande qualité des renseignements qu'ils obtiennent des témoins et des victimes. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INTERVIEWING
KW  - INVESTIGATIONS
KW  - ABILITY
KW  - WITNESSES
KW  - CHILDREN
N1  - Accession Number: 900542; Lamb, Michael E. 1 Sternberg, Kathleen J. 1 Esplin, Phillip W.; Affiliation:  1: Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, USA; Source Info: Aug98, Vol. 22 Issue 8, p813; Subject Term: INTERVIEWING; Subject Term: INVESTIGATIONS; Subject Term: ABILITY; Subject Term: WITNESSES; Subject Term: CHILDREN; Number of Pages: 11p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Charukamnoetkanok, Puwat
AU  - Fukushima, Atsuki
AU  - Whitcup, Scott M.
AU  - Gery, Igal
AU  - Egwuagu, Charles E.
T1  - Expression of ocular autoantigens in the mouse thymus.
JO  - Current Eye Research
JF  - Current Eye Research
Y1  - 1998/08//
VL  - 17
IS  - 8
M3  - Article
SP  - 788
EP  - 792
PB  - Taylor & Francis Ltd
SN  - 02713683
AB  - PURPOSE. The occurrence of eye diseases of autoimmune nature, as well as experimental models of these diseases, has been attributed to the sequestration of ocular antigens from the immune system, that prevents the development of tolerance against these antigens. Here, we tested this assertion by examining whether transcripts of certain ocular antigens are constitutively expressed in the thymus, the site of central tolerance induction. METHOD. RNA was isolated from the eyes and thymi of two mouse strains and analyzed for the expression of genes encoding four retinal and three lens proteins by reverse transcribed-polymerase chain reaction, Southern blot and DNA sequence analyses. RESULTS. We detected gene transcripts of S-Antigen (S-Ag), interphotoreceptor retinoid-binding protein, opsin, recoverin, lens major intrinsic protein (MIP), αA-, αA -ins- and γ-crystallins in the thymi of BALB/c and FVB/N mouse strains. DNA sequence analysis of the thymic MIP and S-Ag transcripts confirmed their identity to the lens and retinal proteins, respectively. CONCLUSIONS. Our results reveal that transcripts of several ocular-specific proteins are expressed in the thymus and suggest that the commonly held view that ocular-specific antigens are sequestered from the immune system should be modified. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Current Eye Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENS
KW  - THYMUS
KW  - EYE -- Diseases
KW  - IMMUNOLOGY
KW  - immunotolerance
KW  - mouse
KW  - ocular-specific autoantigens
KW  - RT-PCR
KW  - thymic expression of antigens
N1  - Accession Number: 5258732; Charukamnoetkanok, Puwat 1,2 Fukushima, Atsuki 1 Whitcup, Scott M. 1 Gery, Igal 1 Egwuagu, Charles E. 1; Affiliation:  1: National Institutes of Health, Laboratory of Immunology, National Eye Institute, MD, Maryland, Bethesda, USA  2: Howard Hughes Medical Institute, NIH Research Scholars Program, MD, Maryland, Bethesda, USA; Source Info: Aug98, Vol. 17 Issue 8, p788; Subject Term: ANTIGENS; Subject Term: THYMUS; Subject Term: EYE -- Diseases; Subject Term: IMMUNOLOGY; Author-Supplied Keyword: immunotolerance; Author-Supplied Keyword: mouse; Author-Supplied Keyword: ocular-specific autoantigens; Author-Supplied Keyword: RT-PCR; Author-Supplied Keyword: thymic expression of antigens; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Illustrations: 18 Black and White Photographs, 1 Diagram; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107296465
T1  - Is the risk of diabetic retinopathy greater in non-Hispanic blacks and Mexican Americans than in non-Hispanic whites with type 2 diabetes?: a U.S. population study.
AU  - Harris MI
AU  - Klein R
AU  - Cowie CC
AU  - Rowland M
AU  - Byrd-Holt DD
Y1  - 1998/08//
N1  - Accession Number: 107296465. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Diabetic Retinopathy -- Epidemiology
KW  - Blacks
KW  - Hispanics
KW  - Whites
KW  - Diabetes Mellitus, Type 2
KW  - Risk Factors
KW  - Kappa Statistic
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Multiple Logistic Regression
KW  - Step-Wise Multiple Regression
KW  - Odds Ratio
KW  - P-Value
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 1230
EP  - 1235
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 21
IS  - 8
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To compare the risk for diabetic retinopathy in non-Hispanic white, non-Hispanic black, and Mexican-American adults with type 2 diabetes in the U.S. population. RESEARCH DESIGN AND METHODS: Representative population-based samples of people aged > or = 40 years in each of the three racial/ethnic groups were studied in the 1988-1994 Third National Health and Nutrition Examination Survey (NHANES III). Diagnosed diabetes was ascertained by medical history interview, and undiagnosed diabetes by measurement of fasting plasma glucose. A fundus photograph of a single eye was taken with a nonmydriatic camera, and a standardized protocol was used to grade diabetic retinopathy. Information on risk factors for retinopathy was obtained by interview and standard laboratory procedures. RESULTS: Prevalence of any lesions of diabetic retinopathy in people with diagnosed diabetes was 46% higher in non-Hispanic blacks and 84% higher in Mexican Americans, compared with non-Hispanic whites. Blacks and Mexican Americans also had higher rates of moderate and severe retinopathy and higher levels of many putative risk factors for retinopathy. Blacks had lower retinopathy prevalence among those with undiagnosed diabetes. In logistic regression, retinopathy in people with diagnosed diabetes was associated only with measures of diabetes severity (duration of diabetes, HbA1c, level, treatment with insulin and oral agents) and systolic blood pressure. After adjustment for these factors, the risk of retinopathy in Mexican Americans was twice that of non-Hispanic whites, but non-Hispanic blacks were not at higher risk for retinopathy. These risks were similar when people with undiagnosed diabetes were included in the logistic regression models. CONCLUSIONS: The prevalence and severity of diabetic retinopathy is greater in non-Hispanic blacks and Mexican Americans with type 2 diabetes in the U.S. population than in non-Hispanic whites. For blacks, this can be attributed to their higher levels of risk factors for retinopathy, but the excess risk in Mexican Americans is unexplained.
SN  - 0149-5992
AD  - National Institutes of Health, Natcher Building, Room 5AN24, 45 Center Dr., Bethesda, MD 20892; e-mail: harrism@ep.niddk.nih.gov
U2  - PMID: 9702425.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Zhou, Y-Y.
AU  - Lakatta, E.G.
AU  - Xiao, R-P.
T1  - Age-Associated Alterations in Calcium Current and its Modulation in Cardiac Myocytes.
JO  - Drugs & Aging
JF  - Drugs & Aging
Y1  - 1998/08//
VL  - 13
IS  - 2
M3  - Article
SP  - 159
EP  - 171
PB  - Springer Science & Business Media B.V.
SN  - 1170229X
AB  - The calcium current is one of the most important components in cardiac excitation-contraction coupling. During aging, the magnitude of L-type Ca channel current (I) is significantly increased in parallel with the enlargement of cardiac myocytes, resulting in unaltered I density. Since the inactivation of I is slowed and the action potential duration is prolonged, the net Ca influx during each action potential is likely to be increased in senescent hearts relative to young ones. This augmentation of Ca influx may be important for the preserved cardiac function of the older heart in the basal state. However, it increases the risk of Ca overload and Ca-dependent arrhythmias in the senescent heart. During stress, the response of I to β-adrenergic receptor stimulation is markedly reduced, which may be an important cause of the age-related decrease in cardiac reserve function. These age-dependent changes in I and its modulations are similar to those observed in the enlarged myocytes of the hypertrophied and failing heart. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Drugs & Aging is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALCIUM channels
KW  - EXCITATION (Physiology)
KW  - AGING -- Psychological aspects
KW  - Elderly
KW  - Heart-failure, pathogenesis
KW  - Left-ventricular-hypertrophy, pathogenesis
KW  - Reviews-on-disease
KW  - Right-ventricular-hypertrophy, pathogenesis
N1  - Accession Number: 9526260; Zhou, Y-Y. 1 Lakatta, E.G. 1 Xiao, R-P. 1; Affiliation:  1: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA; Source Info: 1998, Vol. 13 Issue 2, p159; Subject Term: CALCIUM channels; Subject Term: EXCITATION (Physiology); Subject Term: AGING -- Psychological aspects; Author-Supplied Keyword: Elderly; Author-Supplied Keyword: Heart-failure, pathogenesis; Author-Supplied Keyword: Left-ventricular-hypertrophy, pathogenesis; Author-Supplied Keyword: Reviews-on-disease; Author-Supplied Keyword: Right-ventricular-hypertrophy, pathogenesis; Number of Pages: 13p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Scepek, Susanne
AU  - Coorssen, Jens R.
AU  - Lindau, Manfred
T1  - Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/08//8/1/98
VL  - 17
IS  - 15
M3  - Article
SP  - 4340
EP  - 4345
SN  - 02614189
AB  - Using the patch-clamp technique, we studied the role of protein phosphorylation and dephosphorylation on the exocytotic fusion of secretory granules with the plasma membrane in horse eosinophils. Phorbol 12-myristate 13-acetate (PMA) had no effect on the amplitude and dynamics of degranulation, indicating that the formation of fusion pores is insensitive to activation of protein kinase C (PKC). Fusion pore expansion, however, was accelerated ∼2-fold by PMA, and this effect was abolished by staurosporine. Elevating intracellular Ca2+ to 1.5 μM also resulted in a 2-fold acceleration of pore expansion; this effect was not prevented by staurosporine, indicating that intracellular Ca2+ and activation of PKC accelerate fusion pore expansion via distinct mechanisms. However, fusion pores can expand fully even when PKC is inhibited. In contrast, the phosphatase inhibitor -naphthylphosphate inhibits exocytotic fusion and slows fusion pore expansion. These results demonstrate that, subsequent to its formation, fusion pore expansion is under control of proteins subject to functional changes based on their phosphorylation states. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXOCYTOSIS
KW  - MEMBRANE fusion
KW  - PATCH-clamp techniques (Electrophysiology)
KW  - PROTEINS
KW  - PHOSPHORYLATION
KW  - HORSES
KW  - EOSINOPHILS
KW  - capacitance
KW  - exocytosis
KW  - membrane fusion
KW  - patch-clamp
KW  - staurosporine
N1  - Accession Number: 13003458; Scepek, Susanne 1 Coorssen, Jens R. 2 Lindau, Manfred 3; Email Address: ml95@cornell.edu; Affiliation:  1: Department of Molecular Cell Research, Max-Planck-Institute for Medical Research, Jahnstrasse Heidelberg, Germany  2: Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, Center Dr. MSC, Bethesda, MD  3: School of Applied and Engineering Physics, Cornell University, Clark Hall, Ithaca, NY, USA; Source Info: 8/1/98, Vol. 17 Issue 15, p4340; Subject Term: EXOCYTOSIS; Subject Term: MEMBRANE fusion; Subject Term: PATCH-clamp techniques (Electrophysiology); Subject Term: PROTEINS; Subject Term: PHOSPHORYLATION; Subject Term: HORSES; Subject Term: EOSINOPHILS; Author-Supplied Keyword: capacitance; Author-Supplied Keyword: exocytosis; Author-Supplied Keyword: membrane fusion; Author-Supplied Keyword: patch-clamp; Author-Supplied Keyword: staurosporine; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3  - 10.1093/emboj/17.15.4340
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107181194
T1  - Finding information about rare diseases -- then what?
AU  - Groft SC
AU  - Jones P
AU  - Pikus AT
AU  - Demory MC
AU  - Clay SE
Y1  - 1998/08//
N1  - Accession Number: 107181194. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Consumer Health; USA. NLM UID: 7702637. 
KW  - Disease
KW  - World Wide Web
KW  - Consumer Health Information
SP  - 46
EP  - 50
JO  - Exceptional Parent
JF  - Exceptional Parent
JA  - EXCEPTIONAL PARENT
VL  - 28
IS  - 8
CY  - Johnstown, Pennsylvania
PB  - EP World, Inc.
SN  - 0046-9157
AD  - Office of Rare Diseases, National Institutes of Health
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Boissy, Raymond E.
AU  - Sakai, Chie
AU  - Zhao, Huiquan
AU  - Kobayashi, Takeshi
AU  - Hearing, Vincent J.
T1  - Human tyrosinase related protein-1 (TRP-1) does not function as a DHICA oxidase activity in contrast to murine TRP-1.
JO  - Experimental Dermatology
JF  - Experimental Dermatology
Y1  - 1998/08//
VL  - 7
IS  - 4
M3  - Article
SP  - 198
EP  - 204
SN  - 09066705
AB  - Tyrosinase related protein-1 is a melanocyte specific protein and a member of the tyrosinase gene family which also includes tyrosinase and TRP-2 ( DOPAchromc tautomerase). In murine melanocytes. TRP-I functions as a 5,6-dihydroxyindole-2-carboxylic acid [DHICA] oxidase during the biosynthetic conversion of tyrosine to eumelanin and mutations affecting TRP-I result in the synthesis of brown rather than black pelage coloration. In this study. we examined the putative DHICA oxidase activity of TRP- I in human melanocytes using several approaches. We first utilized a line of cultured melanocytes established from a patient with a form of oculocutaneous albinism completely lacking expression of TRP- I (OCA3). This line of melanocytes endogenously exhibited the same amount of DH ICA oxidase activity as control melanocytes expressing TRP-I. In other experiments. cultured human fibroblast were transected with a Edna for TARP- I, in either the sense or antisense direction, or with the retroviral vector alone. TRP-I expression was induced in fibroblasts transfected with the TRP- I eDNA in the sense direction only. Although TRP- I was expressed by sense-transfected cells, there Was lit) significant DHICA oxidase activity above controls. These results demonstrate that human TRP-l does not use DHICA as a substrate for oxidation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHENOL oxidase
KW  - MELANOCYTES
KW  - ALBINOS & albinism
KW  - FIBROBLASTS
KW  - GENES
KW  - EPITHELIAL cells
KW  - pigmentation
N1  - Accession Number: 11904362; Boissy, Raymond E. 1; Email Address: boissyre@email.uc.edu Sakai, Chie 2 Zhao, Huiquan 1 Kobayashi, Takeshi 2 Hearing, Vincent J. 2; Affiliation:  1: Department of Dermatology. University of Cincinnati College ol Medicine. Cincinnati. OH  2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health. Bethesda. MD, USA; Source Info: Aug98, Vol. 7 Issue 4, p198; Subject Term: PHENOL oxidase; Subject Term: MELANOCYTES; Subject Term: ALBINOS & albinism; Subject Term: FIBROBLASTS; Subject Term: GENES; Subject Term: EPITHELIAL cells; Author-Supplied Keyword: pigmentation; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sakamoto, Shinji
T1  - The Effects of Self-Focus on Negative Mood Among Depressed and Nondepressed Japanese Students.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1998/08//
VL  - 138
IS  - 4
M3  - Article
SP  - 514
EP  - 523
PB  - Taylor & Francis Ltd
SN  - 00224545
AB  - The article presents information about a study that examined the effects of self-focus on positive mood and negative mood in a sample of Japanese university students. In the study, the author randomly assigned 120 Japanese undergraduates (63 men, 57 women) to one of the three conditions of attention focus (self, other, social). Questionnaires were prepared for each of the three focus conditions. The results of the study confirmed the hypothesis that when depressed participants focus their attention on themselves, they are more conscious of their personal shortcomings and experience more negative moods than do their nondepressed counterparts. When they turn their attention to other people or to the social environment, however, the differences in mood between depressed and nondepressed participants disappear.
KW  - HUMAN behavior
KW  - COLLEGE students
KW  - JAPANESE
KW  - PESSIMISM
KW  - OPTIMISM
KW  - PERSONALITY
N1  - Accession Number: 822825; Sakamoto, Shinji 1; Affiliation:  1: Department of Sociocultural Environmental Research National Institute of Mental Health National Center of Neurology and Psychiatry, Chiba, Japan; Source Info: Aug1998, Vol. 138 Issue 4, p514; Subject Term: HUMAN behavior; Subject Term: COLLEGE students; Subject Term: JAPANESE; Subject Term: PESSIMISM; Subject Term: OPTIMISM; Subject Term: PERSONALITY; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 3625
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107155441
T1  - Lingual action in normal sequential swallowing.
AU  - Chi-Fishman G
AU  - Stone M
AU  - McCall GN
Y1  - 1998/08//
N1  - Accession Number: 107155441. Language: English. Entry Date: 20050507. Revision Date: 20150818. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Grant Information: National Institute on Deafness and Other Communication Disorders and the Kay Elemetrics Corporation. NLM UID: 9705610. 
KW  - Deglutition -- Physiology
KW  - Tongue -- Physiology
KW  - Funding Source
KW  - Electrodiagnosis
KW  - Palate -- Ultrasonography
KW  - Female
KW  - Male
KW  - Adult
KW  - Middle Age
KW  - Biophysiological Methods
KW  - Oscilloscope
KW  - Repeated Measures
KW  - Descriptive Research
KW  - Ultrasonography
KW  - Two-Way Analysis of Variance
KW  - Human
SP  - 771
EP  - 785
JO  - Journal of Speech, Language & Hearing Research
JF  - Journal of Speech, Language & Hearing Research
JA  - JSLHR J SPEECH LANG HEAR RES
VL  - 41
IS  - 4
CY  - Rockville, Maryland
PB  - American Speech-Language-Hearing Association
AB  - Current knowledge about the flexibility in lingual motor control and performance during swallowing is incomplete. The present study aimed at gaining a better understanding of the tongue's motor flexibility and at identifying variable versus invariant lingual motor program parameters in light of changing swallowing task demands (discrete vs. sequential). Specifically, the timing and patterns of tongue-palate contact and the associated changes in tongue shape and action were examined in 5 normal adults using simultaneous electropalatography and ultrasound. Tasks for discrete swallowing included 5 and 30 cc of water; tasks for sequential swallowing involved drinking 200 cc of water at normal and fast rates. Results showed little variation in propulsive contact pattern as a function of task or subject. However, the tongue demonstrated shorter movement duration and overlapping gestures during sequential swallowing. Thus, continuous drinking was performed without changes in motor strategies per se but with changes in the timing coordination of the 'drink' and 'swallow' action sequences. These findings support the theory that the deglutitive lingual motor program has both invariant and variant parameters, and that movement pattern and action sequence reflect fixed elements within the structure of the motor program, but movement timing can be modified according to the demands of the task at hand.
SN  - 1092-4388
AD  - Vocal Tract Visualization Laboratory, Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD. E-mail: gcf@nih.gov
U2  - PMID: 9712125.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104798950
T1  - Sensory changes in the territory of the lingual and inferior alveolar nerves following lower third molar extraction.
AU  - Eliav, E
AU  - Gracely, R H
Y1  - 1998/08//1998 Aug
N1  - Accession Number: 104798950. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Lingual Nerve -- Physiology
KW  - Mandibular Nerve -- Physiology
KW  - Molar -- Surgery
KW  - Neurons, Afferent -- Physiology
KW  - Tooth Extraction
KW  - Adolescence
KW  - Adult
KW  - Electric Stimulation
KW  - Female
KW  - Heat
KW  - Human
KW  - Lingual Nerve
KW  - Male
KW  - Mandibular Nerve
KW  - Middle Age
KW  - Nerve Fibers -- Physiology
KW  - Neurons, Afferent
KW  - Pain -- Physiopathology
KW  - Pain Threshold
KW  - Physical Stimulation
KW  - Touch -- Physiology
SP  - 191
EP  - 199
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 77
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Clinical Measurement and Mechanisms Unit, Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
U2  - PMID: 9766837.
DO  - 10.1016/S0304-3959(98)00100-6
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107162929
T1  - Assessing functional outcomes: an overview.
AU  - Frattali CM
Y1  - 1998/08//
N1  - Accession Number: 107162929. Language: English. Entry Date: 19990201. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8405117. 
KW  - Functional Assessment
KW  - Communicative Disorders -- Diagnosis
KW  - Outcome Assessment
KW  - Education, Continuing (Credit)
KW  - International Classification of Functioning, Disability, and Health
SP  - 209
EP  - 324
JO  - Seminars in Speech & Language
JF  - Seminars in Speech & Language
JA  - SEMIN SPEECH LANG
VL  - 19
IS  - 3
CY  - New York, New York
PB  - Thieme Medical Publishing Inc.
AB  - Assessment of functional outcomes requires, first, a good working definition and, second, sufficiently reliable and valid measures from which to choose. With the advent of new or refined conceptualizations of patient outcomes, the functional domain has expanded to address not only routine activities of daily life but also the richly diverse aspects believed to constitute quality of life. This article defines and places the concept of functional outcomes within a context of various published and proposed classification schemes, and supports an expanded definition on the basis of these schemes, emerging models of health care that combine biomedical with social science approaches, and the visionary contributions of respected colleagues in the field.
SN  - 0734-0478
AD  - National Institutes of Health, W.G. Magnuson Clinical Center, Rehabilitation Medicine Department, Speech-Language Pathology Science, 10 Center Drive, MSC 1604, Bethesda, Maryland 20892-1604
U2  - PMID: 9720127.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107162929&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2004-17585-009
AN  - 2004-17585-009
AU  - Wiggins, Jerry S.
T1  - That 'disturbing little book' is back!
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1998/08//
VL  - 43
IS  - 8
SP  - 548
EP  - 549
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17585-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wiggins, Jerry S.; National Institute on Aging, US. Release Date: 20040927. Correction Date: 20170130. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Judgment (Not Diagnosis); Clinicians; Evaluation Criteria; Prediction; Statistical Analysis. Minor Descriptor: Therapists. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Meehl, Paul E. Clinical Versus Statistical Prediction: A Theoretical Analysis and a Review of the Evidence=Northvale, NJ: Jason Aronson, 1954 (reprinted 1996). 149 pp. $35.00; 1996. References Available: Y. Page Count: 2. Issue Publication Date: Aug, 1998. 
AB  - The author notes that the seemingly straightforward topic of this extended essay (see record [rid]2006-21565-000[/rid]) was the relative merits of clinical (case study) and statistical (actuarial) methods of combining assessment data on a single patient to forecast future performance. Clinical data combination in psychology and medicine is based on known relations between predictors and criteria, but the final interpretation of these data often relies heavily on the psychologist or physician who has had a great deal of experience in these matters. The initial impetus for Meehl's work was the argument of Sarbin (1944) that it was irrational to expect the clinician to improve on actuarial methods of combining clinical assessment data. As a therapist, Meehl could not accept the idea that the clinician is a second-rate computer. As a scientist and philosopher of science, Meehl's attack on this issue was two-fold: (a) to carry out a 'logical reconstruction' of clinical activity that would demonstrate, in principle, that there are situations in which it is possible to make use of judgmental procedures over and above the use of actuarial tables and (b) to review the literature for studies that compared the relative accuracy of clinical and statistical prediction. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - assessment data
KW  - predict future performance
KW  - clinician
KW  - actuarial methods
KW  - clinical assessment data
KW  - therapist
KW  - judgment
KW  - clinical prediction
KW  - statistical prediction
KW  - 1998
KW  - Clinical Judgment (Not Diagnosis)
KW  - Clinicians
KW  - Evaluation Criteria
KW  - Prediction
KW  - Statistical Analysis
KW  - Therapists
KW  - 1998
U2  - Meehl, Paul E. (1996); Clinical Versus Statistical Prediction: A Theoretical Analysis and a Review of the Evidence; Northvale, NJ: Jason Aronson, 1954 (reprinted 1996). 149 pp. $35.00; 1-56821-831-1 (Paperback).
DO  - 10.1037/001715
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13479-006
AN  - 2008-13479-006
AU  - Maric, Dragan
AU  - Maric, Irina
AU  - Smith, Susan V.
AU  - Serafini, Ruggero
AU  - Hu, Qian
AU  - Barker, Jeffery L.
T1  - Potentiometric study of resting potential, contributing K+ channels and the onset of Na+ channel excitability in embryonic rat cortical cells.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1998/08//
VL  - 10
IS  - 8
SP  - 2532
EP  - 2546
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Maric, Dragan, Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US, 20892
N1  - Accession Number: 2008-13479-006. PMID: 9767384 Partial author list: First Author & Affiliation: Maric, Dragan; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Embryo; Neurons; Rats; Sodium Ions. Minor Descriptor: Membranes. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Aug, 1998. 
AB  - Resting membrane potential (RMP), K+ channel contribution to RMP and the development of excitability were investigated in the entire population of acutely dissociated embryonic (E) rat cortical cells over E11-22 using a voltage-sensitive fluorescent indicator dye and flow cytometry. During the period of intense proliferation (E11-13), two cell subpopulations with distinct estimated RMPs were recorded: one polarized at ∼ -70 mV and the other relatively less-polarized at ∼ -40 mV. Ca2+o was critical in sustaining the RMP of the majority of less-polarized cells, while the well-polarized cells were characterized by membrane potentials exhibiting a ∼ Nernstian relationship between RMP and [K+]o. Analysis of these two subpopulations revealed that > 80% of less-polarized cells were proliferative, while > 90% of well-polarized cells were postmitotic. Throughout embryonic development, the disappearance of Ca2+o-sensitive, less-polarized cells correlated with the disappearance of the proliferating population, while the appearance of the K+o-sensitive, well-polarized population correlated with the appearance of terminally postmitotic neurons, immuno-identified as BrdU-, tetanus toxin+ cells. Differentiating neurons were estimated to contain increased K+i relative to less-polarized cells, coinciding with the developmental expression of Cs+/Ba2+-sensitive and Ca2+-dependent K+ channels. Both K+ channels contributed to the RMP of well-polarized cells, which became more negative toward the end of neurogenesis. Depolarizing effects of veratridine, first observed at E11, progressively changed from Ca2+o-dependent and tetrodotoxin-insensitive to Na+o-dependent and tetrodotoxin-sensitive response by E18. The results reveal a dynamic development of RMP, contributing K+ channels and voltage-dependent Na+ channels in the developing cortex as it transforms from proliferative to primarily differentiating tissue. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - resting potential
KW  - potassium channels
KW  - sodium channel excitability
KW  - embryonic rat cortical cells
KW  - 1998
KW  - Embryo
KW  - Neurons
KW  - Rats
KW  - Sodium Ions
KW  - Membranes
KW  - 1998
DO  - 10.1046/j.1460-9568.1998.00284.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13479-006&site=ehost-live&scope=site
UR  - dragan@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41745-008
AN  - 2015-41745-008
AU  - Cheng, Clara M.
AU  - Joncas, George
AU  - Reinhardt, Rickey R.
AU  - Farrer, Robert
AU  - Quarles, Richard
AU  - Janssen, Jeremy
AU  - McDonald, Michael P.
AU  - Crawley, Jacqueline N.
AU  - Powell-Braxton, Lynn
AU  - Bondy, Carolyn A.
T1  - Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/08//
VL  - 18
IS  - 15
SP  - 5673
EP  - 5681
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Cheng, Clara M., National Institutes of Health, Building 10/10N262, 10 Center Drive, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-41745-008. PMID: 9671658 Partial author list: First Author & Affiliation: Cheng, Clara M.; Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Phosphodiesterase; Insulin-like Growth Factor. Minor Descriptor: Mice; Oligodendrocytes. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: Aug, 1998. Publication History: Accepted Date: May 6, 1998; Revised Date: Apr 24, 1998; First Submitted Date: Feb 27, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - To elucidate the role of insulin-like growth factor 1 (IGF1) in the normal development of brain myelination, we used behavioral, biochemical, and histological analyses to compare the myelination of brains from Igf1-/- and wild-type (WT) littermate mice. The studies were conducted at postnatal day 40, at which time the Igf1-/- mice weighed ~66% less than wild-type mice. However, the Igf1-/- brain weight was only reduced by ~34%. Formal neurological testing showed no sign of central or peripheral myelinopathy in Igf1-/- mice. Myelin composition was not significantly different, and myelin concentration, normalized to brain weight or protein, was equal in Igf1-/- and WT mice. Likewise, concentrations of myelin-specific proteins (MBP, myelin proteolipid protein, MAG, and 2',3'-cyclic nucleotide,3'-phosphodiesterase) were not significantly different in Igf1-/- and WT mice. The myelin-associated lipids galactocerebroside and sulfatide were modestly reduced in Igf1-/- brains. Regional oligodendrocyte populations and myelin staining patterns were comparable in Igf1-/- and WT brains, with the notable exception of the olfactory system. The Igf1-/- olfactory bulb was profoundly reduced in size and was depleted of mitral neurons and oligodendrocytes, and its efferent tracts were depleted of myelin. In summary, this study shows that myelination of the Igf1-/- brain is proportionate to its neuronal composition. Where projection neurons are preserved despite the deletion of IGF1, as in the cerebellar system, oligodendrocytes and myelination are indistinguishable from wild type. Where projection neurons are depleted, as in the olfactory bulb, oligodendrocytes are also depleted, and myelination is reduced in proportion to the reduced projection neuron mass. These data make a strong case for the primacy of axonal factors, not including IGF1, in determining oligodendrocyte survival and myelination. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - IGF1
KW  - oligodendrocyte
KW  - olfactory bulb
KW  - myelin basic protein (MBP)
KW  - myelin proteolipid protein (PLP)
KW  - 29
KW  - 39- cyclic nucleotide
KW  - 39-phosphodiesterase (CNPase)
KW  - myelinassociated glycoprotein (MAG)
KW  - 1998
KW  - Brain
KW  - Phosphodiesterase
KW  - Insulin-like Growth Factor
KW  - Mice
KW  - Oligodendrocytes
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41745-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41746-029
AN  - 2015-41746-029
AU  - Gilmore, Edward C.
AU  - Ohshima, Toshio
AU  - Goffinet, André M.
AU  - Kulkarni, Ashok B.
AU  - Herrup, Karl
T1  - Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/08//
VL  - 18
IS  - 16
SP  - 6370
EP  - 6377
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gilmore, Edward C., School of Medicine, Case Western Reserve Medical School, E504, 10900 Euclid Avenue, Cleveland, OH, US, 44106
N1  - Accession Number: 2015-41746-029. PMID: 9698328 Partial author list: First Author & Affiliation: Gilmore, Edward C.; Department of Neuroscience, Case Western Reserve Medical School, Cleveland, OH, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Herrup, Karl. Major Descriptor: Cerebral Cortex; Kinases; Neurons; Migration of Nerve Cells. Minor Descriptor: Mice. Classification: Psychopharmacology (2580). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 1998. Publication History: Accepted Date: May 27, 1998; Revised Date: May 20, 1998; First Submitted Date: Mar 9, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - The cerebral cortex of mice with a targeted disruption in the gene for cyclin-dependent kinase 5 (cdk5) is abnormal in its structure. Bromodeoxyuridine labeling reveals that the normal inside-out neurogenic gradient is inverted in the mutants; earlier born neurons are most often found superficial to those born later. Despite this, the early preplate layer separates correctly and neurons with a normal, pyramidal morphology can be found between true marginal zone and subplate. Consistent with their identity as layer VI corticothalamic neurons, they can be labeled by DiI injections into thalamus. The DiI injections also reveal that the trajectories of the cdk5-/- thalamocortical axons are oblique and cut across the entire cortical plate, instead of being oriented tangentially in the subcortical white matter. We propose a model in which the cdk5-/- defect blocks cortical development at a heretofore undescribed intermediate stage, after the splitting of the preplate, but before the migration of the full complement of cortical neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuronal migration
KW  - cdk5
KW  - reeler
KW  - cerebral cortical development
KW  - neuronal morphology
KW  - BrdU
KW  - 1998
KW  - Cerebral Cortex
KW  - Kinases
KW  - Neurons
KW  - Migration of Nerve Cells
KW  - Mice
KW  - 1998
U1  - Sponsor: National Institutes of Health, US. Grant: NS20591. Recipients: Herrup, Karl
U1  - Sponsor: National Institute of Dental Research. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Neurological Diseases and Stroke, DIR. Recipients: Kulkarni, Ashok B.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41746-030
AN  - 2015-41746-030
AU  - Behar, Toby N.
AU  - Schaffner, Anne E.
AU  - Scott, Catherine A.
AU  - O'Connell, Casey
AU  - Barker, Jeffery L.
T1  - Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/08//
VL  - 18
IS  - 16
SP  - 6378
EP  - 6387
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Behar, Toby N., Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 2C02, 36 Convent Drive, Bethesda, MD, US, 20892-4066
N1  - Accession Number: 2015-41746-030. PMID: 9698329 Partial author list: First Author & Affiliation: Behar, Toby N.; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160825. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gamma Aminobutyric Acid; Depolarization; Migration of Nerve Cells. Minor Descriptor: Neural Receptors; Rats. Classification: Electrophysiology (2530). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Aug, 1998. Publication History: Accepted Date: May 29, 1998; Revised Date: May 22, 1998; First Submitted Date: Mar 17, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - A microdissection technique was used to separate differentiated cortical plate (cp) cells from immature ventricular zone cells (vz) in the rat embryonic cortex. The cp population contained >85% neurons (TUJ1+), whereas the vz population contained ~60% precursors (nestin+ only). The chemotropic response of each population was analyzed in vitro, using an established microchemotaxis assay. Micromolar GABA (1–5 µM) stimulated the motility of cp neurons expressing glutamic acid decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis. In contrast, femtomolar GABA (500 fM) directed a subset of GAD- vz neurons to migrate. Thus, the two GABA concentrations evoked the motility of phenotypically distinct populations derived from different anatomical regions. Pertussis toxin (PTX) blocked GABA-induced migration, indicating that chemotropic signals involve G-protein activation. Depolarization by micromolar muscimol, elevated [K+]o, or micromolar glutamate arrested migration to GABA or GABA mimetics, indicating that migration is inhibited in the presence of excitatory stimuli. These results suggest that GABA, a single ligand, can promote motility via G-protein activation and arrest attractant-induced migration via GABAA receptor-mediated depolarization. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - development
KW  - chemotaxis
KW  - cortex
KW  - G-protein
KW  - depolarization
KW  - neuron
KW  - migration
KW  - 1998
KW  - Gamma Aminobutyric Acid
KW  - Depolarization
KW  - Migration of Nerve Cells
KW  - Neural Receptors
KW  - Rats
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41746-030&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Mofenson, Lynne M.
AU  - Mofenson, L M
T1  - Perinatal transmission of HIV in women receiving zidovudine: abstract and commentary.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1998/08/12/
VL  - 280
IS  - 6
M3  - journal article
SP  - 569
EP  - 570
SN  - 00987484
AB  - Discusses a study that evaluates the impact of perinatal zidovudine use on the risk of perinatal transmission of HIV.  Determination of risk factors for transmission among women using perinatal zidovudine; Design of study; Methods; Results; Conclusions; Commentary.
KW  - AZT (Drug)
KW  - HIV infections -- Transmission
KW  - HIV-positive persons -- Medical care
KW  - ANTIVIRAL agents
KW  - DRUGS -- Effectiveness
N1  - Accession Number: 959933; Mofenson, Lynne M. Mofenson, L M 1; Affiliation:  1: National Institute of Child Health and Human Development, Pediatric, Adolescent and Maternal AIDS Branch, Bethesda, MD, USA; Source Info: 8/12/98, Vol. 280 Issue 6, p569; Subject Term: AZT (Drug); Subject Term: HIV infections -- Transmission; Subject Term: HIV-positive persons -- Medical care; Subject Term: ANTIVIRAL agents; Subject Term: DRUGS -- Effectiveness; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bäriund, M.
AU  - Nupponen, N. N.
AU  - Karhu, R.
AU  - Tanner, M. M.
AU  - Paavola, P.
AU  - Kallioniemi, O. -P.
AU  - Kallioniemi, A.
T1  - Molecular cytogenetic mapping of 24 CEPH YACs and 24 gene-specific large insert probes to chromosome 17.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/08/15/
VL  - 82
IS  - 3/4
M3  - Article
SP  - 189
EP  - 191
SN  - 03010171
AB  - Defining boundaries of chromosomal rearrangements at the molecular level would benefit from landmarks that link the cytogenetic map to physical, genetic, and transcript maps, as well as from large-insert FISH probes for such loci to detect numerical and structural rearrangements in metaphase or interphase cells. Here, we determined the locations of 24 genetically mapped CEPH-Mega YACs along the FLpter scale (fractional length from p-telomere) by quantitative fluorescence in situ hybridization analysis. This generated a set of cytogenetically mapped probes for chromosome 17 with an average spacing of about 5 cM. We then developed large-insert YAC, BAC, PAC, or P1 clones to the following 24 known genes, and determined refined map locations along the same FLpter scale: pter–TP53–TOP3–cen–TNFAIP1–ERBB2–TOP2A–BRCA1–TCF11–NME1–HLF–ZNF147/CLN80–BCL5/MPO/SFRS1–TBX2–PECAM1–DDX5/PRKCA–ICAM2–GH1/PRKAR1A–GRB2–CDK3/FKHL13–qter. Taken together, these 48 cytogenetically mapped large-insert probes provide tools for the molecular analysis of chromosome 17 rearrangements, such as mapping amplification, deletion, and translocation breakpoints in this chromosome, in cancer and other diseases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cytogenetics & Cell Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HUMAN gene mapping
KW  - HUMAN chromosomes
KW  - HUMAN genetics
KW  - TELOMERES
KW  - CYTOGENETICS
KW  - FLUORESCENCE in situ hybridization
KW  - HOMOLOGY (Biology)
N1  - Accession Number: 12184300; Bäriund, M. 1,2 Nupponen, N. N. 1 Karhu, R. 1 Tanner, M. M. 1 Paavola, P. 3 Kallioniemi, O. -P. 2 Kallioniemi, A. 2; Email Address: akallion@nhgri.nih.gov; Affiliation:  1: Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.  2: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.  3: National Public Health Institute, Department ofHuman Molecular Genetics, Helsinki, Finland.; Source Info: Aug98, Vol. 82 Issue 3/4, p189; Subject Term: HUMAN gene mapping; Subject Term: HUMAN chromosomes; Subject Term: HUMAN genetics; Subject Term: TELOMERES; Subject Term: CYTOGENETICS; Subject Term: FLUORESCENCE in situ hybridization; Subject Term: HOMOLOGY (Biology); Number of Pages: 3p; Document Type: Article
L3  - 10.1159/000015096
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rajcan-Separovic, E.
AU  - Barcelo, J. M.
AU  - Korneluk, R. G.
T1  - Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/08/15/
VL  - 82
IS  - 3/4
M3  - Article
SP  - 247
EP  - 250
SN  - 03010171
AB  - Myotonic dystrophy (DM) is caused by an expansion of a CTG repeat sequence in the 3′ noncoding region of a protein kinase gene (DMPK) at 19q13.3. We used in situ hybridization to analyse the replication timing of the genomic region containing DMPK in fibroblasts and myoblasts from controls and myotonic dystrophy patients. In this method the relative proportion of singlet to doublet hybridization signals is used to infer the relative time of replication of specific loci or regions. Our results show that in cells from normal individuals approximately 65% of signals appear as doublets, indicating early replication. In DM patients with a number of CTG repeats ranging from about 600–1800 we observed a significant increase of singlet-doublets compared to the background level. These results suggest the existence of replication alternations and/or structural differences between the normal and mutant alleles induced by the presence of the DM mutation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cytogenetics & Cell Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MYOTONIA atrophica
KW  - PATIENTS
KW  - FLUORESCENCE in situ hybridization
KW  - DYSTROPHY
KW  - PROTEIN kinases
KW  - PHOSPHOTRANSFERASES
KW  - MYOBLASTS
N1  - Accession Number: 12184285; Rajcan-Separovic, E. 1; Email Address: bob@mgcheo.med.uottawa.ca Barcelo, J. M. 2 Korneluk, R. G. 3; Affiliation:  1: British Columbia's Children's Hospital, Vancouver, BC, Canada.  2: National Institute of Child Health and Human Development, Cell Biology and Metabolism Branch, Bethesda MD, USA.  3: Molecular Genetics Research Laboratory, Children's Hospital of Eastern Ontario, Ottawa, Canada.; Source Info: Aug98, Vol. 82 Issue 3/4, p247; Subject Term: MYOTONIA atrophica; Subject Term: PATIENTS; Subject Term: FLUORESCENCE in situ hybridization; Subject Term: DYSTROPHY; Subject Term: PROTEIN kinases; Subject Term: PHOSPHOTRANSFERASES; Subject Term: MYOBLASTS; Number of Pages: 4p; Document Type: Article
L3  - 10.1159/000015111
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Markus, Michelle A.
AU  - Gerstner, Resi B.
AU  - Draper, David E.
AU  - Torchia, Dennis A.
T1  - The solution structure of ribosomal protein S4 ?41 reveals two subdomains and a positively charged surface that may interact with RNA.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/08/15/
VL  - 17
IS  - 16
M3  - Article
SP  - 4559
EP  - 4571
SN  - 02614189
AB  - S4 is one of the first proteins to bind to 16S RNA during assembly of the prokaryotic ribosome. Residues 43–200 of S4 from Bacillus stearothermophilus (S4 Δ41) bind specifically to both 16S rRNA and to a pseudoknot within the α operon mRNA. As a first step toward understanding how S4 recognizes and organizes RNA, we have solved the structure of ΔS4 41 in solution by multidimensional heteronuclear nuclear magnetic resonance spectroscopy. The fold consists of two globular subdomains, one comprised of four helices and the other comprised of a five-stranded antiparallel β-sheet and three helices. Although cross-linking studies suggest that residues between helices α2 and α3 are close to RNA, the concentration of positive charge along the crevice between the two subdomains suggests that this could be an RNA-binding site. In contrast to the L11 RNA-binding domain studied previously, S4 Δ41 shows no fast local motions, suggesting that it has less capacity for refolding to fit RNA. The independently determined crystal structure of S4 Δ41 shows similar features, although there is small rotation of the subdomains compared with the solution structure. The relative orientation of the subdomains in solution will be verified with further study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RNA
KW  - RIBOSOMES
KW  - BACILLUS (Bacteria)
KW  - OPERONS
KW  - SPECTRUM analysis
KW  - HELICES (Algebraic topology)
KW  - modular proteins
KW  - multidimensional nmr
KW  - protein­nucleic acid interactions
KW  - ribosomal proteins
KW  - ribosome assembly
N1  - Accession Number: 13003503; Markus, Michelle A. 1 Gerstner, Resi B. 2 Draper, David E. 2 Torchia, Dennis A. 1; Email Address: torchia@yoda.nidr.nih.gov; Affiliation:  1: Molecular Structural Biology Unit, National Institute of Dental Research, National Institutes of Health, 30 Convent Drive, Room 132, Bethesda, MD 20892-4320  2: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA; Source Info: 8/15/98, Vol. 17 Issue 16, p4559; Subject Term: RNA; Subject Term: RIBOSOMES; Subject Term: BACILLUS (Bacteria); Subject Term: OPERONS; Subject Term: SPECTRUM analysis; Subject Term: HELICES (Algebraic topology); Author-Supplied Keyword: modular proteins; Author-Supplied Keyword: multidimensional nmr; Author-Supplied Keyword: protein­nucleic acid interactions; Author-Supplied Keyword: ribosomal proteins; Author-Supplied Keyword: ribosome assembly; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/17.16.4559
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Caffrey, Michael
AU  - Cai, Mengli
AU  - Kaufman, Joshua
AU  - Stahl, Stephen J.
AU  - Wingfield, Paul T.
AU  - Covell, David G.
AU  - Gronenborn, Angela M.
AU  - Clore, G. Marius
T1  - Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/08/15/
VL  - 17
IS  - 16
M3  - Article
SP  - 4572
EP  - 4584
SN  - 02614189
AB  - The solution structure of the ectodomain of simian immunodeficiency virus (SIV) gp41 (e-gp41), consisting of residues 27–149, has been determined by multi-dimensional heteronuclear NMR spectroscopy. SIV e-gp41 is a symmetric 44 kDa trimer with each subunit consisting of antiparallel N-terminal (residues 30–80) and C-terminal (residues 107–147) helices connected by a 26 residue loop (residues 81–106). The N-terminal helices of each subunit form a parallel coiled-coil structure in the interior of the complex which is surrounded by the C-terminal helices located on the exterior of the complex. The loop region is ordered and displays numerous intermolecular and non-sequential intramolecular contacts. The helical core of SIV e-gp41 is similar to recent X-ray structures of truncated constructs of the helical core of HIV-1 e-gp41. The present structure establishes unambiguously the connectivity of the N- and C-terminal helices in the trimer, and characterizes the conformation of the intervening loop, which has been implicated by mutagenesis and antibody epitope mapping to play a key role in gp120 association. In conjunction with previous studies, the solution structure of the SIV e-gp41 ectodomain provides insight into the binding site of gp120 and the mechanism of cell fusion. The present structure of SIV e-gp41 represents one of the largest protein structures determined by NMR to date. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SIMIAN viruses
KW  - SPECTRUM analysis
KW  - HELICES (Algebraic topology)
KW  - X-rays
KW  - MUTAGENESIS
KW  - CELL hybridization
KW  - PROTEINS
KW  - cell fusion
KW  - ectodomain
KW  - gp41
KW  - hiv
KW  - siv
N1  - Accession Number: 13003502; Caffrey, Michael 1 Cai, Mengli 1 Kaufman, Joshua 2 Stahl, Stephen J. 2 Wingfield, Paul T. 2 Covell, David G. 3 Gronenborn, Angela M. 1; Email Address: gronenborn@vger.niddk.nih.gov Clore, G. Marius 1; Email Address: clore@speck.niddk.nih.gov; Affiliation:  1: Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520  2: Protein Expression Laboratory, Building 6B, National Institute of Athritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-2775  3: Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702, USA; Source Info: 8/15/98, Vol. 17 Issue 16, p4572; Subject Term: SIMIAN viruses; Subject Term: SPECTRUM analysis; Subject Term: HELICES (Algebraic topology); Subject Term: X-rays; Subject Term: MUTAGENESIS; Subject Term: CELL hybridization; Subject Term: PROTEINS; Author-Supplied Keyword: cell fusion; Author-Supplied Keyword: ectodomain; Author-Supplied Keyword: gp41; Author-Supplied Keyword: hiv; Author-Supplied Keyword: siv; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/17.16.4572
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Markley, John L.
AU  - Bax, Ad
AU  - Arata, Yoji
AU  - Hilbers, C. W.
AU  - Kaptein, Robert
AU  - Sykes, Brian D.
AU  - Wright, Peter E.
AU  - Wüthrich, Kurt
T1  - Recommendations for the presentation of NMR structures of proteins and nucleic acids.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1998/08/15/Aug98 Part 2
VL  - 256
IS  - 1
M3  - Article
SP  - 1
EP  - 15
PB  - Wiley-Blackwell
SN  - 00142956
AB  - The recommendations presented here are designed to support easier communication of NMR data and NMR structures of proteins and nucleic acids through unified nomenclature and reporting standards. Much of this document pertains to the reporting of data in journal articles; however, in the interest of the future development of structural biology, it is desirable that the bulk of the reported information be stored in computer-accessible form and be freely accessible to the scientific community in standardized formats for data exchange. These recommendations stem from an IUPAC-IUBMB-IUPAB inter-union venture with the direct involvement of ICSU and CODATA. The Task Group has reviewed previous formal recommendations and has extended them in the light of more recent developments in the field of biomolecular NMR spectroscopy. Drafts of the recommendations presented here have been examined critically by more than 50 specialists in the field and have gone through two rounds of extensive modification to incorporate suggestions and criticisms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUCLEAR magnetic resonance
KW  - PROTEINS
KW  - NUCLEIC acids
KW  - CHEMICAL structure
N1  - Accession Number: 5276718; Markley, John L. 1 Bax, Ad 2 Arata, Yoji 3 Hilbers, C. W. 4 Kaptein, Robert 5 Sykes, Brian D. 6 Wright, Peter E. 7 Wüthrich, Kurt 8; Affiliation:  1: Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA  2: Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland, USA  3: Water Research Institute, Tsukuba, Japan  4: Laboratory of Biophysical Chemistry, University of Nijmegen, The Netherlands  5: Department of Chemistry, University of Utrecht, The Netherlands  6: Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada  7: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA  8: Institut für Molekularbiologie und Biophysik, ETH-Hönggerberg, Zürich, Switzerland; Source Info: Aug98 Part 2, Vol. 256 Issue 1, p1; Subject Term: NUCLEAR magnetic resonance; Subject Term: PROTEINS; Subject Term: NUCLEIC acids; Subject Term: CHEMICAL structure; Number of Pages: 15p; Illustrations: 9 Diagrams, 3 Charts; Document Type: Article
L3  - 10.1046/j.1432-1327.1998.2560001.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107281641
T1  - Cancer risk in women exposed to diethylstilbestrol in utero.
AU  - Hatch EE
AU  - Palmer JR
AU  - Titus-Ernstoff L
AU  - Noller KL
AU  - Kaufman RH
AU  - Mittendorf R
AU  - Robboy SJ
AU  - Hyer M
AU  - Cowan CM
AU  - Adam E
AU  - Colton T
AU  - Hartge P
AU  - Hoover RN
AU  - Hatch, E E
AU  - Palmer, J R
AU  - Titus-Ernstoff, L
AU  - Noller, K L
AU  - Kaufman, R H
AU  - Mittendorf, R
AU  - Robboy, S J
Y1  - 1998/08/19/
N1  - Accession Number: 107281641. Language: English. Entry Date: 19980901. Revision Date: 20161112. Publication Type: journal article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Diethylstilbestrol -- Adverse Effects -- In Utero
KW  - Neoplasms -- Epidemiology
KW  - Fetus
KW  - Risk Factors
KW  - Daughters
KW  - Prenatal Exposure Delayed Effects
KW  - Incidence
KW  - Female
KW  - Questionnaires
KW  - Regression
KW  - Confidence Intervals
KW  - Record Review
KW  - Relative Risk
KW  - Adult
KW  - Middle Age
KW  - Prospective Studies
KW  - Human
SP  - 630
EP  - 634
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 280
IS  - 7
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: The association between in utero exposure to diethylstilbestrol (DES) and clear cell adenocarcinoma (CCA) of the vagina and cervix is well known, yet there has been no systematic study of DES-exposed daughters to determine whether they have an increased risk of other cancers. As many as 3 million women in the United States may have been exposed to DES in utero.Objective: To determine whether women exposed to DES in utero have a higher risk of cancer after an average of 16 years of follow-up.Design: A cohort study with mailed questionnaires and medical record review of reported cancer outcomes.Participants: A cohort of 4536 DES-exposed daughters (of whom 81% responded) and 1544 unexposed daughters (of whom 79% responded) who were first identified in the mid-1970s.Main Outcome Measures: Cancer incidence in DES-exposed daughters compared with population-based rates and compared with cancer incidence in unexposed daughters.Results: To date, DES-exposed daughters have not experienced an increased risk for all cancers (rate ratio, 0.96; 95% confidence interval [CI], 0.58-1.56) or for individual cancer sites, except for CCA. Three cases of vaginal CCA occurred among the exposed daughters, resulting in a standardized incidence ratio of 40.7 (95% CI, 13.1-126.2) in comparison with population-based incidence rates. The rate ratio for breast cancer was 1.18 (95% CI, 0.56-2.49); adjustment for known risk factors did not alter this result.Conclusions: Thus far, DES-exposed daughters show no increased cancer risk, except for CCA. Nevertheless, because exposed daughters included in our study were, on average, only 38 years old at last follow-up, continued surveillance is warranted to determine whether any increases in cancer risk occur during the menopausal years.
SN  - 0098-7484
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7362, USA
U2  - PMID: 9718055.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107285658
T1  - Can quality of clinical trials and meta-analyses be quantified?
AU  - Ioannidis JPA
AU  - Lau J
Y1  - 1998/08/22/
N1  - Accession Number: 107285658. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - Clinical Trials -- Evaluation
KW  - Meta Analysis -- Evaluation
SP  - 590
EP  - 591
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 352 North American Edition
IS  - 9128
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Therapeutics Research Program, DAIDS/NIAID, National Institutes of Health, Bethesda, MD 20852
U2  - PMID: 9746014.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Zohar, Muriel
AU  - Teramoto, Hidemi
AU  - Katz, Ben-Zion
AU  - Yamada, Kenneth M.
AU  - Gutkind, J. Silvio
T1  - Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation.
JO  - Oncogene
JF  - Oncogene
Y1  - 1998/08/27/
VL  - 17
IS  - 8
M3  - Article
SP  - 991
EP  - 998
PB  - Nature Publishing Group
SN  - 09509232
AB  - The small GTP-binding Rho proteins control a variety of biological activities, including organization of the actin cytoskeleton, regulation of gene expression and cellular transformation. In contrast, Ras proteins do not induce actin stress fibers, but potently transform cells which exhibit a morphology clearly distinct from that caused by activated forms of Rho. To investigate whether nuclear signaling and oncogenic potential of Rho are a consequence of its profound effect on cytoskeletal organization, we replaced each amino acid in the Rho effector loop with those of Ras, or replaced conserved residues with others known to result in differential signaling capability when introduced into Ras and Rac1. These Rho mutants did not gain the ability to induce the MAPK, JNK or p38 pathways but, surprisingly, all Rho effector loop mutants still continued to induce actin stress fiber formation. However, three of these Rho mutants, with substitutions of leucine-39, glutamic acid-39, or cysteine-42, lost the ability to stimulate gene transcription via the serum response factor (SRF) and failed to induce neoplastic transformation. Thus, these results indicate that cytoskeletal changes are not sufficient to induce the transformed phenotype, and that Rho-effector molecules regulating the actin cytostructure are distinct from those signaling to the nucleus and subverting normal growth control. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOSKELETAL proteins
KW  - PROTEINS
KW  - ACTOMYOSIN
KW  - ACTIN
KW  - CELLS
KW  - Ras
KW  - Rho A GTPase
KW  - signal transduction
KW  - small G-proteins
KW  - stress fibers
KW  - transformation
N1  - Accession Number: 11352150; Zohar, Muriel 1 Teramoto, Hidemi 1 Katz, Ben-Zion 2 Yamada, Kenneth M. 2 Gutkind, J. Silvio 1; Affiliation:  1: Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892-4330, USA  2: Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892-4330, USA; Source Info: 8/27/98, Vol. 17 Issue 8, p991; Subject Term: CYTOSKELETAL proteins; Subject Term: PROTEINS; Subject Term: ACTOMYOSIN; Subject Term: ACTIN; Subject Term: CELLS; Author-Supplied Keyword: Ras; Author-Supplied Keyword: Rho A GTPase; Author-Supplied Keyword: signal transduction; Author-Supplied Keyword: small G-proteins; Author-Supplied Keyword: stress fibers; Author-Supplied Keyword: transformation; Number of Pages: 8p; Illustrations: 1 Color Photograph, 2 Black and White Photographs, 2 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3  - 10.1038/sj.onc.1202022
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ju-Ock Kim, Marion M.
AU  - Nau, Kathrine A.
AU  - Allikian, Tomi P.
AU  - Mäkelaä, Kari
AU  - Alitalo, Bruce E.
AU  - Johnson, Michael J.
AU  - Kelley
T1  - Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.
JO  - Oncogene
JF  - Oncogene
Y1  - 1998/08/27/
VL  - 17
IS  - 8
M3  - Article
SP  - 1019
EP  - 1026
PB  - Nature Publishing Group
SN  - 09509232
AB  - Specific genetic alterations affecting proto-oncogenes of the myc gene family are frequently detected in human lung cancer. Among 11 SCLC cell lines with L-myc gene amplification, four were found to have alteration of the RLF gene by Southern blot and RT–PCR analyses. One cell line, NCI-H378, contained aberrantly-sized L-myc-hybridizing bands by Southern and Northern blot hybridization but had no alteration of RLF. Some L-myc-hybridizing cDNAs from NCI-H378 contained a novel sequence with close homology to the cyclophilins joined to antisense L-myc exon 2 sequence. Full length cDNAs isolated from human skeletal muscle containing only the novel sequence identify open reading frames of 301 and 296 amino acids and differ in the C-terminal region by 22 and 17 amino acids. This gene, tentatively named PPIE (peptidyl-prolyl cis-trans isomerase E), has 83% amino acid identity with the central conserved region of cyclophilin A, is evolutionarily conserved by Southern blot, and exhibits differential tissue expression with highest levels found in muscle and brain. Co-amplification of PPIE was observed in seven of eleven L-myc amplified cell lines. Analysis of radiation hybrids suggests that the gene order is RLF-PPIE-L-myc on chromosome 1p and pulse-field gel electrophoresis localizes all three genes to an 800 megabase Mlu I fragment. The prognostic and functional consequences of PPIE gene amplification in SCLC can now be determined. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEPTIDYLPROLYL isomerase
KW  - CELL lines
KW  - CANCER cells
KW  - CELL culture
KW  - CELLS
KW  - CIS-trans-isomerases
KW  - alternative splicing
KW  - cyclophilin
KW  - gene amplification
KW  - L-myc
KW  - small cell lung cancer
KW  - tumor cell line
N1  - Accession Number: 11352155; Ju-Ock Kim, Marion M. 1,2 Nau, Kathrine A. 1 Allikian, Tomi P. 1 Mäkelaä, Kari 3 Alitalo, Bruce E. 3 Johnson, Michael J. 1 Kelley 1; Affiliation:  1: Lung Cancer Biology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland, 20889-5105 USA  2: Department of Internal Medicine; Chungnam National University Hospital; 640 Daesadong Jungku, Taejon, Korea 301-040  3: Laboratory of Cancer Biology, Department of Virology and Pathology, University of Helsinki, 00290 Helsinki, Finland; Source Info: 8/27/98, Vol. 17 Issue 8, p1019; Subject Term: PEPTIDYLPROLYL isomerase; Subject Term: CELL lines; Subject Term: CANCER cells; Subject Term: CELL culture; Subject Term: CELLS; Subject Term: CIS-trans-isomerases; Author-Supplied Keyword: alternative splicing; Author-Supplied Keyword: cyclophilin; Author-Supplied Keyword: gene amplification; Author-Supplied Keyword: L-myc; Author-Supplied Keyword: small cell lung cancer; Author-Supplied Keyword: tumor cell line; Number of Pages: 8p; Illustrations: 6 Diagrams, 1 Chart; Document Type: Article
L3  - 10.1038/sj.onc.1202006
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107291425
T1  - Using behavioral research to address drug abuse and AIDS.
AU  - Leshner AI
Y1  - 1998/09//
N1  - Accession Number: 107291425. Language: English. Entry Date: 19981101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9712133. 
KW  - Substance Abuse -- Prevention and Control
KW  - HIV Infections -- Prevention and Control
KW  - Behavioral Research -- Utilization
KW  - Behavioral Changes
KW  - Risk Taking Behavior
SP  - 263
EP  - 265
JO  - AIDS & Behavior
JF  - AIDS & Behavior
JA  - AIDS BEHAV
VL  - 2
IS  - 3
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - Drug abuse and the spread of HIV/AIDS are intertwined public health problems that require many and multifaceted solutions. Behavioral and social science research plays an important role in helping us to understand and develop solutions to these related epidemics. Behavioral research supported by the National Institute on Drug Abuse (NIDA) has demonstrated that drug users are amenable to behavior change strategies. Drug abuse treatment, prevention and community-based outreach programs have all been found to be effective in reducing drug use, needle-sharing practices, unsafe sex behaviors, as well as risk for HIV infection.
SN  - 1090-7165
AD  - National Institute on Drug Abuse, National Institutes of Health, 5600 Fishers Lane, Room 10-5, Rockville, Maryland 20857. E-mail: leshner@nih.gov
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107167489
T1  - An update on drug interactions with zidovudine.
AU  - Piscitelli SC
AU  - Polis MA
Y1  - 1998/09//
N1  - Accession Number: 107167489. Language: English. Entry Date: 20050507. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225. 
KW  - Drug Interactions
KW  - Zidovudine
SP  - 687
EP  - 690
JO  - AIDS Patient Care & STDs
JF  - AIDS Patient Care & STDs
JA  - AIDS PATIENT CARE STDS
VL  - 12
IS  - 9
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
SN  - 1087-2914
AD  - Department of Pharmacy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
U2  - PMID: 15468442.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107167489&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107170454
T1  - High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study.
AU  - Visser M
AU  - Langlois J
AU  - Guralnik JM
AU  - Cauley JA
AU  - Kronmal RA
AU  - Robbins J
AU  - Williamson JD
AU  - Harris TB
Y1  - 1998/09//
N1  - Accession Number: 107170454. Language: English. Entry Date: 19990301. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D); Health Interview Survey Supplement on Aging Questionnaire. NLM UID: 0376027. 
KW  - Body Composition
KW  - Obesity -- Complications
KW  - Walking
KW  - Physical Mobility
KW  - Adipose Tissue
KW  - Electric Impedance
KW  - Disability Evaluation
KW  - Center for Epidemiological Studies Depression Scale
KW  - Psychological Tests
KW  - Research Instruments
KW  - Cross Sectional Studies
KW  - Prospective Studies
KW  - Data Analysis Software
KW  - Logistic Regression
KW  - Multiple Linear Regression
KW  - Confidence Intervals
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Male
KW  - Human
SP  - 584
EP  - 590
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 68
IS  - 3
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Using data from the Cardiovascular Health Study, we studied the relation between body composition (fat mass and fat-free mass, assessed by bioelectrical impedance) and self-reported, mobility-related disability (difficulty walking or stair climbing) in 2714 women and 2095 men aged 65-100 y. In a cross-sectional analysis at baseline (1989-1990), disability was reported by 26.5% of the women and 16.9% of the men. A positive association was observed between fat mass and disability. The odds ratio for disability in the highest quintile of fat mass was 3.04 (95% CI: 2.18, 4.25) for women and 2.77 (95% CI: 1.82, 4.23) for men compared with those in the lowest quintile. Low fat-free mass was not associated with a higher prevalence of disability. In a longitudinal analysis among persons not reporting disability at baseline, 20.3% of the women and 14.8% of the men reported disability 3 y later. Fat mass at baseline was predictive of disability 3 y later, with odds ratios of 2.83 (95% CI: 1.80, 4.46) for women and 1.72 (95% CI: 1.03, 2.85) for men in the highest quintile of fat. The increased risk was not explained by age, physical activity, chronic disease, or other potential confounders. Low fat-free mass was not predictive of disability. The results showed that high body fatness is an independent predictor of mobility-related disability in older men and women. These findings suggest that high body fatness in old age should be avoided to decrease the risk of disability. Copyright (c) 1998 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Institute on Aging, Epidemiology, Demography, and Biometry Program, Bethesda, MD
U2  - PMID: 9734734.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107293064
T1  - Clinical evaluation of noninvasive monitoring of oxygen saturation in critically ill patients.
AU  - Smatlak P
AU  - Knebel AR
Y1  - 1998/09//1998 Sep
N1  - Accession Number: 107293064. Language: English. Entry Date: 19981101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9211547. 
KW  - Pulse Oximetry
KW  - Oxygen Saturation -- Evaluation
KW  - Equipment Reliability
KW  - Critically Ill Patients
KW  - Convenience Sample
KW  - Monitoring, Physiologic
KW  - Descriptive Statistics
KW  - Pulse Oximetry -- Evaluation
KW  - Evaluation Research
KW  - Arterial Pressure -- Evaluation
KW  - Pulmonary Wedge Pressure -- Evaluation
KW  - Oximetry -- Equipment and Supplies
KW  - T-Tests
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Inpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 370
EP  - 373
JO  - American Journal of Critical Care
JF  - American Journal of Critical Care
JA  - AM J CRIT CARE
VL  - 7
IS  - 5
CY  - Alisa Veijo, California
PB  - American Association of Critical-Care Nurses
AB  - OBJECTIVE To examine the effect of abnormal cardiac index on the accuracy of measurement of oxygen saturation by pulse oximetry. METHODS Forty-six patients (mean age, 49 years) in a 9-bed medical ICU were studied. Measurements of oxygen saturation obtained with pulse oximeters and with a functional cooximeter were collected at baseline and 4, 8, 16, 24, 32, 40, and 48 hours later. Hemodynamic and cardiopulmonary parameters were recorded. RESULTS The Bland-Altman technique yielded upper and lower limits of agreement of 2.53% and -7.11%. Most (95.7%) of the differences between the measurements of oxygen saturation obtained with the 2 methods were within these limits, although some of these differences may be clinically unacceptable. The bias was -2.29%, and the precision was 2.41%. The clinical conditions associated with inaccurate tracking of saturation by pulse oximetry across the range of actual arterial oxygen saturation values were abnormal cardiac index, partial pressure of carbon dioxide, heart rate, and pulmonary capillary wedge pressure. CONCLUSIONS In patients with abnormal cardiac index, the pulse oximeter measurements exceeded the actual oxygen saturation by up to 7%. Pending prospective studies, clinicians should be aware that when certain cardiopulmonary parameters are abnormal, the margin of error in measurements of oxygen saturation obtained with a pulse oximeter may be greater than when those parameters are normal.
SN  - 1062-3264
AD  - Clinical Center Nursing Department, National Institutes of Health, Bethesda, Md
U2  - PMID: 9740887.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107293064&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107994609
T1  - Play Development in Children With HIV Infection: A Pilot Study.
AU  - Parks, Rebecca A.
AU  - Oakley, Frances
AU  - Fonseca, Mary
Y1  - 1998/09//
N1  - Accession Number: 107994609. Language: English. Entry Date: 20130617. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Revised Play History (Behnke and Menarchek-Fetkovich). NLM UID: 7705978. 
KW  - Play and Playthings
KW  - Child Development
KW  - HIV Infections -- Complications -- In Infancy and Childhood
KW  - Psychomotor Performance -- In Infancy and Childhood
KW  - Pilot Studies
KW  - Convenience Sample
KW  - Behavior Rating Scales
KW  - HIV Infections -- Classification
KW  - Child, Preschool
KW  - Child
KW  - Male
KW  - Female
KW  - Human
SP  - 672
EP  - 675
JO  - American Journal of Occupational Therapy
JF  - American Journal of Occupational Therapy
JA  - AM J OCCUP THER
VL  - 52
IS  - 8
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
SN  - 0272-9490
AD  - Senior Occupational Therapist in Pediarrics and Occupational Therapy Education Coordinator, Rehabilitation Medicine Department, National Institutes of Health, Building 10, Room 6S-235, 10 Center Drive, MSC 1604, Bethesda, Maryland 20892-1604
AD  - Research Coordinator, Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland
AD  - Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9739402.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107994609&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107167771
T1  - Joel A. DeLisa Lecturship. The National Center for Medical Rehabilitation Research: beyond infancy, looking toward maturity.
AU  - Fuhrer MJ
Y1  - 1998/09//1998 Sep-Oct
N1  - Accession Number: 107167771. Language: English. Entry Date: 19990301. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8803677. 
KW  - National Institutes of Health (U.S.) -- Administration
KW  - Rehabilitation
KW  - Research Support
KW  - Training Support, Financial
SP  - 437
EP  - 443
JO  - American Journal of Physical Medicine & Rehabilitation
JF  - American Journal of Physical Medicine & Rehabilitation
JA  - AM J PHYS MED REHABIL
VL  - 77
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0894-9115
AD  - The National Center for Medical Rehabilitation Research, The National Institute of Child Health and Human Development, The National Institutes of Health, Building 61E/Room 2A03, 6100 Executive Boulevard, Rockville, MD 20852
U2  - PMID: 9798837.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107167771&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107161934
T1  - Evaluating cluster alarms: a space-time scan statistic and brain cancer in Los Alamos, New Mexico.
AU  - Kulldorff M
AU  - Athas WF
AU  - Feuer EJ
AU  - Miller BA
AU  - Key CR
Y1  - 1998/09//
N1  - Accession Number: 107161934. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Supported in part by the Swedish Council for Research in the Humanities and Social Sciences. NLM UID: 1254074. 
KW  - Brain Neoplasms -- Epidemiology
KW  - Cluster Analysis -- Methods
KW  - Epidemiological Research
KW  - Incidence
KW  - Data Analysis, Statistical
KW  - P-Value
KW  - Registries, Disease
KW  - Data Analysis Software
KW  - Relative Risk
KW  - New Mexico
KW  - Public Health
KW  - Geographic Factors
KW  - Funding Source
KW  - Human
SP  - 1377
EP  - 1380
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 88
IS  - 9
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This article presents a space-time scan statistic, useful for evaluating space-time cluster alarms, and illustrates the method on a recent brain cancer cluster alarms in Los Alamos, NM. METHODS: The space-time scan statistic accounts for the preselection bias and multiple testing inherent in a cluster alarm. Confounders and time trends can be adjusted for. RESULTS: The observed excess of brain cancer in Los Alamos was not statistically significant. CONCLUSIONS: The space-time scan statistic is useful as a screening tool for evaluating which cluster alarms merit further investigation and which clusters are probably chance occurrences.
SN  - 0090-0036
AD  - EPN 344, National Cancer Institute, 6130 Executive Blvd, Bethesda, MD 20892-7368
U2  - PMID: 9736881.
DO  - 10.2105/AJPH.88.9.1377
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104799866
T1  - Atropine premedication and the cardiovascular response to electroconvulsive therapy.
AU  - Mayur, P M
AU  - Shree, R S
AU  - Gangadhar, B N
AU  - Subbakrishna, D K
AU  - Janakiramaiah, N
AU  - Rao, G S
Y1  - 1998/09//
N1  - Accession Number: 104799866. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0372541. 
KW  - Anesthesia Adjuvants -- Pharmacodynamics
KW  - Atropine -- Pharmacodynamics
KW  - Electroconvulsive Therapy
KW  - Hemodynamics -- Drug Effects
KW  - Premedication
KW  - Adolescence
KW  - Adult
KW  - Blood Pressure -- Drug Effects
KW  - Female
KW  - Heart Rate -- Drug Effects
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Clinical Trials
SP  - 466
EP  - 467
JO  - BJA: The British Journal of Anaesthesia
JF  - BJA: The British Journal of Anaesthesia
JA  - BR J ANAESTH
VL  - 81
IS  - 3
PB  - Oxford University Press / USA
SN  - 0007-0912
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
U2  - PMID: 9861141.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104799866&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Carroll, Raymond J.
AU  - Freedman, Laurence S.
AU  - Kipnis, Victor
AU  - Li, Li
T1  - A new class of measurement-error models, with applications to dietary data.
JO  - Canadian Journal of Statistics
JF  - Canadian Journal of Statistics
Y1  - 1998/09//
VL  - 26
IS  - 3
M3  - Article
SP  - 467
EP  - 477
SN  - 03195724
AB  - La modélisation des erreurs de mesure prend place lorsqu'on ne peut pas observer une covariéee mais qu'on dispose à la place de versions auxiliaires possiblement répliquées de cette covariée mesurée avec erreur. La vaste majorité de la littérature concernant la modélisation des erreurs de mesure suppose (en général avec raison) qu'étant donnée la valeur de la vraie mais non-observée (latente) covariée, les auxiliaires répliquées sont non-biaisées pour la covariées latente et conditonellement indépendantes. Dans le domaine de l'épidémiologie nutritionnelle, il y a évidence provenant d'études bio-marquées que ce modèle d'indépendance conditionnelle simple peut échouer pour deux raisons: (a) des biais systématiques dépendant de l'indice de masse corporelle; et (b) une composante aléatoire de biais additionnelle, de telle sorte que la structure de l'erreur est la měme qu'un modéle d'effets aléatoire à un sens. Nous étudions ce problème dans le contexte (1) de l'estimation de la distribution de l'apport nutritionnel habituel; (2) de l'estimation de la correlation entre un instrument de nutrition et l'apport nutrionnel habituel; et (3) de l'estimation de risque relatif réel du risque relatif estimée en utlisant la covariée portée a l'erreur. Alors que le biais systématique dǔ à l'indice de masse corporelle a peu d'effet, l'effet aléatoire additionnel dans la structure de la variance semble avoir un impact potentiellement important sur les résultats généraux, sur les corrections concernant les estimations de risque relatif et en estimant la distribution de l'apport nutritionnel habituel. Cependant, l'impact des erreurs de mesure diététiques dans les deux facteurs dépend fortement de l'ensemble de données utilisé, tel que le démontrent nos exemples. En fait, un de nos quatre ensemble de données suggère que l'erreur de mesure diététique masque le risque important que repésente le gras par rapport au cancer du sein, alors que sur un deuxième ensemble de données, l'effet de masque n'est pas si clair. Jusqu'à ce qu'une compréhension plus poussée des mesures diététiques soit disponible, des correction d'erreurs de mesure doivent ětre faites sur une base spécifique à l'étude, des analyses de sensibilités devraient ětre menées, et měme dans ce cas, les résultats des études d'épidémiologie nutritionnelle relatives au risque de maladie devront ětre interprétées avec prudence. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Canadian Journal of Statistics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEASUREMENT errors
KW  - GENERALIZED estimating equations
KW  - REGRESSION analysis
KW  - MAXIMUM likelihood statistics
KW  - MOMENTS method (Statistics)
KW  - NUTRITION
N1  - Accession Number: 61888009; Carroll, Raymond J. 1 Freedman, Laurence S. 2 Kipnis, Victor 2 Li, Li 2; Affiliation:  1: Department of Statistics, Texas A&M University, College Station, Texas U.S.A. 77843-3143 email: carroll@stat.tamu.edu  2: National Cancer Institute, Executive Plaza North, Bethesda, Maryland U.S.A. 20892; Source Info: Sep1998, Vol. 26 Issue 3, p467; Subject Term: MEASUREMENT errors; Subject Term: GENERALIZED estimating equations; Subject Term: REGRESSION analysis; Subject Term: MAXIMUM likelihood statistics; Subject Term: MOMENTS method (Statistics); Subject Term: NUTRITION; Number of Pages: 11p; Document Type: Article
L3  - 10.2307/3315770
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107169029
T1  - Antepartum fetal monitoring: when, what, and how.
AU  - Spong CY
Y1  - 1998/09//1998 Sep
N1  - Accession Number: 107169029. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; exam questions; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0367022. 
KW  - Fetal Monitoring, Electronic
KW  - Nonstress Testing, Fetal
KW  - Fetal Biophysical Profile
KW  - Stress Testing, Fetal
KW  - Pregnancy, Multiple
KW  - Practice Guidelines
KW  - Perinatal Death
KW  - Fetal Membranes, Premature Rupture
KW  - Lupus Erythematosus, Systemic
KW  - Pregnancy-Induced Hypertension
KW  - Pregnancy in Diabetes
KW  - Fetal Movement
KW  - Pregnancy
KW  - Female
SP  - 36
EP  - 47
JO  - Contemporary OB/GYN
JF  - Contemporary OB/GYN
JA  - CONTEMP OB GYN
VL  - 43
IS  - 9
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
AB  - Anteparturn testing--standard of care in high-risk pregnancies--can reduce incidence of fetal death to a level below that in the 'low-risk' population. In summarizing the various methods of anteparturn fetal testing, the author clearly describes how to perform each test, interpret results, and proceed with follow up.
SN  - 0090-3159
AD  - Senior Staff Fellow, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Frederikse, Peter H.
AU  - Zigler Jr., Samuel J.
T1  - Presenilin expression in the ocular lens.
JO  - Current Eye Research
JF  - Current Eye Research
Y1  - 1998/09//
VL  - 17
IS  - 9
M3  - Article
SP  - 947
EP  - 952
PB  - Taylor & Francis Ltd
SN  - 02713683
AB  - PURPOSE. Mutations in the presenilin (PS) proteins account for the majority of early onset Alzheimer's disease (AD) cases, apparently by influencing the cleavage of the Alzheimer's disease protein (βAPP) to form β-amyloid (Aβ), the major component of plaques in the brains of AD patients. We reported previously that AD proteins are expressed in mammalian lenses, and that βAPP and Aβ increased in the epithelium and outer cortex of lenses subjected to oxidative stress. This increase paralleled the increase in AP1 DNA binding activity, which has been shown to accompany proliferative oxidative stress responses. Both cataract and AD have been closely linked with oxidative stress; further, both AD and cataract occur in a majority of Down Syndrome individuals. Here we investigate the expression and post-translational processing of PS proteins in the ocular lens. METHODS. In situ hybridization, immuohistochemical detection and immunoblot assays were used to localize mRNA and proteins expression products and determine the approximate molecular weights of the resulting proteins in ocular tissue samples. RESULTS. We report here that PS protein and mRNA are expressed in lenses, and additionally in the cornea, and are proteolytically processed in a manner similar to that demonstrated in brain tissue. PS proteins and mRNAs were localized to the lens epithelium and outer fibers. This pattern agrees with the localization demonstrated by others for mammalian Notch-like receptor proteins. PS and Notch proteins occur together in developmentally regulated cascades of gene expression found in diverse biological systems. <em>Conclusions</em>. PS expression, together with βAPP and Aβ proteins, all associated with age-related degenerative disease, are expressed in lens and might contribute to cataractogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Current Eye Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PRESENILINS
KW  - MESSENGER RNA
KW  - NOTCH proteins
KW  - GENE expression
KW  - Alzheimer's disease
KW  - cataract
KW  - presenilin
KW  - proteolysis
N1  - Accession Number: 5259051; Frederikse, Peter H. 1 Zigler Jr., Samuel J. 1; Affiliation:  1: National Institutes of Health, Laboratory of Mechanisms of Ocular Disease, National Eye Institute, Bethesda, Maryland, USA; Source Info: Sep98, Vol. 17 Issue 9, p947; Subject Term: PRESENILINS; Subject Term: MESSENGER RNA; Subject Term: NOTCH proteins; Subject Term: GENE expression; Author-Supplied Keyword: Alzheimer's disease; Author-Supplied Keyword: cataract; Author-Supplied Keyword: presenilin; Author-Supplied Keyword: proteolysis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107292993
T1  - Intrauterine diabetes exposure and the risk of renal disease in diabetic Pima Indians.
AU  - Nelson RG
AU  - Morgenstern H
AU  - Bennett PH
Y1  - 1998/09//
N1  - Accession Number: 107292993. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372763. 
KW  - Kidney Diseases -- Physiopathology
KW  - Native Americans
KW  - Diabetes Mellitus, Gestational
KW  - Proteinuria -- Epidemiology
KW  - Logistic Regression
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - P-Value
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Urinalysis
KW  - Albumins -- Analysis
KW  - Albumins -- Metabolism
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Pregnancy
KW  - Male
KW  - Female
KW  - Human
SP  - 1489
EP  - 1493
JO  - Diabetes
JF  - Diabetes
JA  - DIABETES
VL  - 47
IS  - 9
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - The association between the diabetic intrauterine environment and renal disease was examined cross-sectionally in 503 Pima Indians with type 2 diabetes. Subjects were selected from participants in an ongoing study of diabetes and its complications in the Gila River Indian Community of Arizona. Subjects' exposure to diabetes in utero was established from periodic examinations conducted as part of the study. The prevalence of elevated urinary albumin excretion (UAE) (albuminto-creatinine ratio >/-30 mg/g) was 40% (83 of 207) in the offspring of nondiabetic mothers, 43% (105 of 246) in the offspring of prediabetic mothers (i.e., women who were not diabetic at the time of the pregnancy but who developed diabetes after the pregnancy), and 58% (29 of 50) in the offspring of mothers who had diabetes during pregnancy. After controlling for age, sex, duration of diabetes, HbA1c, and mean arterial pressure in the offspring in a logistic regression analysis using generalized estimating equations, maternal diabetes during pregnancy was strongly associated with elevated UAE. The odds of elevated UAE in the offspring of mothers who had diabetes during pregnancy was 3.8 times (95% CI 1.7-8.4) that of the offspring of prediabetic mothers; the odds of elevated UAE in the offspring of nondiabetic and prediabetic mothers were similar (odds ratio of 0.94; 95% CI 0.59-1.5). We concluded that exposure to a diabetic intrauterine environment increases the risk of elevated UAE in diabetic Pima Indians. The effect of this exposure appears to be independent of other susceptibility factors that lead to nephropathy in diabetes.
SN  - 0012-1797
AD  - Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Rd., Phoenix, AZ 85014-4972; e-mail: rnelson@phx.niddk.nih.gov
U2  - PMID: 9726239.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Tian Jin
AU  - Soede, Ron D. M.
AU  - Jingchun Liu
AU  - Kimmel, Alan R.
AU  - Devreotes, Peter N.
AU  - Schaap, Pauline
T1  - Temperature-sensitive Gß mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/09//9/1/98
VL  - 17
IS  - 17
M3  - Article
SP  - 5076
EP  - 5084
SN  - 02614189
AB  - Deletion of the single gene for the Dictyostelium G protein β-subunit blocks development at an early stage. We have now isolated temperature-sensitive alleles of Gβ to investigate its role in later development. We show that Gβ is directly required for adenylyl cyclase A activation and for morphogenetic signaling during the entire developmental program. Gβ was also essential for induction of aggregative gene expression by cAMP pulses, a process that is mediated by serpentine cAMP receptors (cARs). However, Gβ was not required for cAR-mediated induction of prespore genes and repression of stalk genes, and neither was Gβ needed for induction of prestalk genes by the differentiation inducing factor (DIF). cAMP induction of prespore genes and repression of stalk genes is mediated by the protein kinase GSK-3. GSK-3 also determines cell-type specification in insects and vertebrates and is regulated by the wingless/wnt morphogens that are detected by serpentine fz receptors. The G protein-dependent and -independent modes of cAR-mediated signaling reported here may also exist for the wingless/wnt signaling pathways in higher organisms. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADENYLATE cyclase
KW  - CELL determination
KW  - G proteins
KW  - SERPENTINE
KW  - DICTYOSTELIUM
KW  - GENES
KW  - adenylyl cyclase
KW  - cell fate specification
KW  - heterotrimeric g protein
KW  - serpentine receptors
KW  - temperature-sensitive alleles
N1  - Accession Number: 13003521; Tian Jin 1 Soede, Ron D. M. 2 Jingchun Liu 3 Kimmel, Alan R. 3 Devreotes, Peter N. 1 Schaap, Pauline 2; Email Address: schaap@rulbim.leidenuniv.nl; Affiliation:  1: Department of Biological Chemistry, Johns Hopkins University School of Medicine, North Wolfe Street, Baltimore, MD  2: Cell Biology Section, Institute for Molecular Plant Sciences, University of Leiden, Wassenaarseweg, AL Leiden, The Netherlands  3: Laboratory of Cell and Developmental Biology, National Institutes of Health, Bethesda, MD, USA; Source Info: 9/1/98, Vol. 17 Issue 17, p5076; Subject Term: ADENYLATE cyclase; Subject Term: CELL determination; Subject Term: G proteins; Subject Term: SERPENTINE; Subject Term: DICTYOSTELIUM; Subject Term: GENES; Author-Supplied Keyword: adenylyl cyclase; Author-Supplied Keyword: cell fate specification; Author-Supplied Keyword: heterotrimeric g protein; Author-Supplied Keyword: serpentine receptors; Author-Supplied Keyword: temperature-sensitive alleles; NAICS/Industry Codes: 212311 Dimension Stone Mining and Quarrying; NAICS/Industry Codes: 212316 Marble mining and quarrying; NAICS/Industry Codes: 212319 Other Crushed and Broken Stone Mining and Quarrying; Number of Pages: 9p; Document Type: Article
L3  - 10.1093/emboj/17.17.5076
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003521&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Asano, Katsura
AU  - Mizobuchi, Kiyoshi
T1  - Copy number control of IncIa plasmid ColIb-P9 by competition between pseudoknot formation and antisense RNA binding at a specific RNA site.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/09//9/1/98
VL  - 17
IS  - 17
M3  - Article
SP  - 5201
EP  - 5213
SN  - 02614189
AB  - Replication of a low-copy-number IncIα plasmid ColIb-P9 depends on expression of the repZ gene encoding the replication initiator protein. repZ expression is negatively controlled by the small antisense Inc RNA, and requires formation of a pseudoknot in the RepZ mRNA consisting of stem-loop I, the Inc RNA target, and a downstream sequence complementary to the loop I. The loop I sequence comprises 5′-rUUGGCG-3′, conserved in many prokaryotic antisense systems, and was proposed to be the important site of copy number control. Here we show that the level of repZ expression is rate-limiting for replication and thus copy number, by comparing the levels of repZ expression and copy number from different mutant ColIb-P9 derivatives defective in Inc RNA and pseudoknot formation. Kinetic analyses using in vitro transcribed RNAs indicate that Inc RNA binding and the pseudoknot formation are competitive at the level of initial base paring to loop I. This initial interaction is stimulated by the presence of the loop U residue in the 5′-rUUGGCG-3′ motif. These results indicate that the competition between the two RNA­RNA interactions at the specific site is a novel regulatory mechanism for establishing the constant level of repZ expression and thus copy number. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MOBILE genetic elements
KW  - GENETIC code
KW  - RNA
KW  - NUCLEOTIDE sequence
KW  - DYNAMICS
KW  - ANTISENSE peptides
KW  - antisense rna
KW  - plasmid replication
KW  - rna loop structure
KW  - rna pseudoknot
KW  - translational coupling
N1  - Accession Number: 13003508; Asano, Katsura 1,2; Email Address: kasano@aghmac1.nichd.nih.gov Mizobuchi, Kiyoshi 3; Affiliation:  1: Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo, Tokyo  2: Laboratory of Eukaryotic Gene Regulation, NICHD, National Institutes of Health, Bethesda, MD, USA  3: Department of Applied Physics and Chemistry, University of Electro-Communications, Chofu-shi, Tokyo, Japan; Source Info: 9/1/98, Vol. 17 Issue 17, p5201; Subject Term: MOBILE genetic elements; Subject Term: GENETIC code; Subject Term: RNA; Subject Term: NUCLEOTIDE sequence; Subject Term: DYNAMICS; Subject Term: ANTISENSE peptides; Author-Supplied Keyword: antisense rna; Author-Supplied Keyword: plasmid replication; Author-Supplied Keyword: rna loop structure; Author-Supplied Keyword: rna pseudoknot; Author-Supplied Keyword: translational coupling; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/17.17.5201
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hohman, Thomas C.
AU  - El-Kabbani, Ossama
AU  - Malamas, Michael S.
AU  - Lai, Kehdih
AU  - Putilina, Tatiana
AU  - McGowan, Michelle H.
AU  - Wane, Yi-Qun
AU  - Carper, Deborah A.
T1  - Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1998/09//Sep98 Part 1
VL  - 256
IS  - 2
M3  - Article
SP  - 310
EP  - 316
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Aldose reductase (AR) has been implicated in the etiology of the secondary complications of diabetes, and enzyme inhibitors have been proposed as therapeutic agents. While effectively preventing the development of diabetic complications in animals, results from clinical studies of AR inhibitors have been disappointing, possibly due to poor potency in man. To assist in the design of more potent and specific inhibitors, crystallographic studies have attempted to identify enzyme-inhibitor interactions. Resolution of crystal complexes has suggested that the inhibitors bind to the enzyme active site and are held in place through hydrogen bonding and van der Waals interactions formed within two hydrophobic pockets. To confirm and extend these findings we quantified inhibitor activity with single, site-directed, mutant, human AR enzymes in which the apolar active-site residues tryptophan 20, -79, -111 and phenylalanine 115 were replaced with alanine or tyrosine, decreasing the potential for van der Waals interactions. Consistent with molecular models, the inhibitory activity of Tolrestat, Sorbinil and Zopolrestat decreased 800-2000-fold when tested with the mutant enzyme in which Trp20 was replaced with alanine. Further, alanine substitution for Trp111 decreased Zopolrestat's activity 400-fold, while mutations to Trp79 and Phe115 had little effect on the activity of any of the inhibitors. The alanine mutation at Trp111 had no effect on Tolrestat's activity but decreased the activity of Sorbinil by about 1000-fold. These latter effects were unanticipated based on the number of non-bonded interactions between the inhibitors, Tolrestat and Sorbinil, and Trp20 and Trp111 that have been identified in the crystal structures. In spite of these unexpected findings, our results are consistent with the hypothesis that AR inhibitors occupy the enzyme active site and that hydrophobic interactions between the enzyme and inhibitor contribute to inhibitor binding stability. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALDOSE reductase
KW  - DIABETES
KW  - CHEMICAL inhibitors
KW  - diabetes.
KW  - enzyme inhibition
KW  - human aldose reductase
KW  - polyol pathway
KW  - site-directed mutagenesis
N1  - Accession Number: 5276656; Hohman, Thomas C. 1 El-Kabbani, Ossama 2 Malamas, Michael S. 1 Lai, Kehdih 1 Putilina, Tatiana 3 McGowan, Michelle H. 3 Wane, Yi-Qun 3 Carper, Deborah A. 3; Affiliation:  1: Wyeth-Ayerst Research, Princeton, USA  2: Department of Medicinal Chemistry, Victorian College of Pharmacy Monash University (Parkville Campus), Parkville, Australia  3: National Eye Institute, National Institutes of Health, Bethesda, USA; Source Info: Sep98 Part 1, Vol. 256 Issue 2, p310; Subject Term: ALDOSE reductase; Subject Term: DIABETES; Subject Term: CHEMICAL inhibitors; Author-Supplied Keyword: diabetes.; Author-Supplied Keyword: enzyme inhibition; Author-Supplied Keyword: human aldose reductase; Author-Supplied Keyword: polyol pathway; Author-Supplied Keyword: site-directed mutagenesis; Number of Pages: 7p; Illustrations: 3 Diagrams, 3 Charts; Document Type: Article
L3  - 10.1046/j.1432-1327.1998.2560310.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cos, Teresa
AU  - Ford, Richard A.
AU  - Trilla, Jose Angel
AU  - Duran, Angel
AU  - Cabib, Enrico
AU  - Roncero, Cesar
T1  - Molecular analysis of Chs3p participation in chitin synthase III activity.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1998/09//Sep98 Part 1
VL  - 256
IS  - 2
M3  - Article
SP  - 419
EP  - 426
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Chitin is a minor but essential component of the cell wall of Saccharomyces cerevisiae, with functions in septum formation in the vegetative life cycle and also in conjugation and spore cell-wall synthesis in the sexual cycle. Of the three chitin synthases present in yeast, chitin synthase III (CSIII) is responsible for the synthesis of most of the chitin found in the cell, including a chitin ring at early budding, chitin interspersed in the cell wall, and chitin laid down during the sexual cycle. We have tagged Chs3p, the putative catalytic subunit of CSIII, with the immunoreactive epitope of influenza virus hemagglutinin to follow expression of the protein. Little correlation was found between the levels of transcription and translation of Chs3p and in vivo function, supporting our previous conclusion that regulation of CSIII occurs at the posttranslational level. To identify possible regions of the protein involved in catalysis or regulation, mutations were generated in the QRRRW ’signature sequence' of chitin synthases. Arginine residue mutations in Chs3p, and in Chs1p and Chs2p, resulted in a loss of both function in vivo and enzymatic activity. Mutations in a serine residue adjacent to glutamine in Chs3p caused loss of function in vivo with a moderate decrease in CSIII activity, suggesting a regulatory role for the serine residue in chitin biosynthesis. Several truncations in the unique hydrophilic carboxy-terminal region of Chs3p identified a sequence of about 25 amino acids that is required for both function and in vitro activity. Since this region is not present in Chs1 or Chs2, it may be involved in the specific regulation of CSIII. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHITIN
KW  - INFLUENZA viruses
KW  - HEMAGGLUTININ
KW  - BIOSYNTHESIS
KW  - calcofluor resistance
KW  - chitin synthase III
KW  - morphogenesis; Saccharomyces cerevisiae.
N1  - Accession Number: 5276642; Cos, Teresa 1 Ford, Richard A. 2 Trilla, Jose Angel 1 Duran, Angel 1 Cabib, Enrico 2 Roncero, Cesar 1; Affiliation:  1: Instituto de Microbiología Bioquímica, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca and Departamento de Microbiología y Genética, Universidad de Salamanca, Spain  2: Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Maryland, USA; Source Info: Sep98 Part 1, Vol. 256 Issue 2, p419; Subject Term: CHITIN; Subject Term: INFLUENZA viruses; Subject Term: HEMAGGLUTININ; Subject Term: BIOSYNTHESIS; Author-Supplied Keyword: calcofluor resistance; Author-Supplied Keyword: chitin synthase III; Author-Supplied Keyword: morphogenesis; Saccharomyces cerevisiae.; Number of Pages: 8p; Illustrations: 7 Black and White Photographs, 10 Diagrams, 3 Charts; Document Type: Article
L3  - 10.1046/j.1432-1327.1998.2560419.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Posch, Phillip E.
AU  - Borrego, Francisco
AU  - Brooks, Andrew G.
AU  - Coligan, John E.
T1  - HLA-E Is the Ligand for the Natural Killer Cell CD94/NKG2 Receptors.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1998/09//
VL  - 5
IS  - 5
M3  - Article
SP  - 321
EP  - 331
PB  - BioMed Central
SN  - 10217770
AB  - CD94/NKG2 is a recently described receptor present on natural killer (NK) cells and certain T cells that is composed of the CD94 chain covalently associated with a member of the NKG2 family of molecules. Both chains are glycosylated members of the C-type lectin superfamily. The CD94/NKG2 receptors are functionally heterogenous depending on which NKG2 family member is associated with CD94. Initially, it was thought that CD94/NKG2 receptors recognized a broad array of HLA-A, -B and -C (classical), as well as the nonclassical HLA-G, MHC class I molecules. Instead, recent data have suggested that this receptor is specific for HLA-E complexed with a peptide derived from the signal sequence (residues 3–11) of certain classical MHC class I molecules. Position 2 (residue 4) in the signal sequence derived peptides appears pivotal in determining whether the HLA-E/peptide complex confers resistance to NK-mediated lysis. The potential roles that the CD94/NKG2-HLA-E receptor ligand interaction might play in infection and tumor development are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIGANDS
KW  - KILLER cells
KW  - MAJOR histocompatibility complex
KW  - IMMUNOCOMPETENT cells
KW  - IMMUNOGENETICS
KW  - CD94
KW  - HLA-E
KW  - Major histocompatibility complex, class I
KW  - Natural killer cells
KW  - NKG2
N1  - Accession Number: 11372045; Posch, Phillip E. 1 Borrego, Francisco 2 Brooks, Andrew G. 1 Coligan, John E. 2; Affiliation:  1: Structural Biology Section  2: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, National Institutes of Health, Twinbrook II, Rockville, Md., USA; Source Info: 1998, Vol. 5 Issue 5, p321; Subject Term: LIGANDS; Subject Term: KILLER cells; Subject Term: MAJOR histocompatibility complex; Subject Term: IMMUNOCOMPETENT cells; Subject Term: IMMUNOGENETICS; Author-Supplied Keyword: CD94; Author-Supplied Keyword: HLA-E; Author-Supplied Keyword: Major histocompatibility complex, class I; Author-Supplied Keyword: Natural killer cells; Author-Supplied Keyword: NKG2; Number of Pages: 11p; Document Type: Article
L3  - 10.1159/000025346
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107167091
T1  - Risk-based recommendations for mammographic screening for women in their forties.
AU  - Gail M
AU  - Rimer B
AU  - Gail, M
AU  - Rimer, B
Y1  - 1998/09//
N1  - Accession Number: 107167091. Language: English. Entry Date: 19990201. Revision Date: 20161120. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: 1R01CA63782/CA/NCI NIH HHS/United States. NLM UID: 8309333. 
KW  - Cancer Screening
KW  - Mammography
KW  - Breast Neoplasms -- Prevention and Control
KW  - Risk Factors
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 3105
EP  - 3114
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 9
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To develop risk-based recommendations for mammographic screening for women in their 40s that take into account the woman's age, race, and specific risk factors.Methods: We assumed that regular mammographic screening is justified for a 50-year-old woman, even one with no risk factors, and that a younger woman with an expected 1-year breast cancer incidence rate as great or greater than that of a 50-year-old woman with no risk factors would benefit sufficiently to justify regular screening. Recommendations under this criterion were based on age- and race-specific breast cancer incidence rates from the National Cancer Institute's (NCI's) Surveillance, Epidemiology, and End Results (SEER) Program; assessments of risk factors from the Breast Cancer Detection and Demonstration Project (BCDDP); and reports in the literature.Results: Two methods, the exact-age procedure (EAP) and the grouped-age procedure (GAP), were developed. The less precise GAP only requires following a flow diagram. The proportion of white women recommended for screening by the EAP ranges from 10% for 40-year-old women to 95% for 49-year-old women, and the corresponding percentages for black women are 16% and 95%. The assumptions that underlie the guidelines are discussed critically.Conclusion: For women or physicians who prefer an individualized approach in deciding whether to initiate regular mammographic screening in the age range of 40 to 49 years, the present report offers recommendations based on individualized risk-factor data and clearly stated assumptions that have an empiric basis. These recommendations can be used to facilitate the counseling process.
SN  - 0732-183X
AD  - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, MD 20892, USA
AD  - National Cancer Institute, 6130 Executive Blvd, EPN/431, Rockville, MD 20892; e-mail: gailm@epndce.nci.nih.gov
U2  - PMID: 9738582.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Fishbein, Diana H.
T1  - DIFFERENTIAL SUSCEPTIBILITY TO COMORBID DRUG ABUSE AND VIOLENCE.
JO  - Journal of Drug Issues
JF  - Journal of Drug Issues
Y1  - 1998///Fall98
VL  - 28
IS  - 4
M3  - Article
SP  - 859
EP  - 890
SN  - 00220426
AB  - Although many psychoactive substances have been associated with violent behavior, only a subgroup manifests excessively aggressive behavior when sober or intoxicated. Theories to explain addictive behaviors in general may directly relate to the specific proclivity to exhibit excessive aggression in this subset of users. Certain personality traits and cognitive deficits coexist in individuals prone to both drug abuse and violence, suggesting a common origin. Because these excessive and compulsive behaviors have been linked with aberrations in the metabolism and activity of the neurotransmitters dopamine and serotonin, their origins may be partly genetic or biological. Alterations in neurotransmitter function influence activities within the brain's reward center to perturb nervous system arousal levels, thereby increasing stimulation-seeking behaviors. Manifestations of these neurobiological aberrations can be measured in physiological and biochemical processes that serve to mediate these behavioral and psychological outcomes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse
KW  - AGGRESSION (Psychology)
KW  - COMPULSIVE behavior
KW  - VIOLENCE
KW  - DRUGS of abuse
KW  - SUBSTANCE abuse
KW  - PERSONALITY
KW  - COGNITION
N1  - Accession Number: 1482887; Fishbein, Diana H. 1,2; Affiliation:  1: University of Maryland, HIDTA Research Program, 7500 Greenway Center Drive, Suite 900, Greenbelt, MD 20770  2: Brain Imaging Center, National Institute on Drug Abuse (NIDA); Source Info: Fall98, Vol. 28 Issue 4, p859; Subject Term: DRUG abuse; Subject Term: AGGRESSION (Psychology); Subject Term: COMPULSIVE behavior; Subject Term: VIOLENCE; Subject Term: DRUGS of abuse; Subject Term: SUBSTANCE abuse; Subject Term: PERSONALITY; Subject Term: COGNITION; Number of Pages: 32p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article; Full Text Word Count: 12052
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107148616
T1  - An affirmation of research and health care for women in the 21st century.
AU  - Pinn VW
Y1  - 1998/09//1998 Sep
N1  - Accession Number: 107148616. Language: English. Entry Date: 20001201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 100887298. 
KW  - Women's Health
KW  - Research, Medical
KW  - Health Policy
KW  - National Institutes of Health (U.S.)
KW  - Medical Organizations
KW  - Female
SP  - 50
EP  - 53
JO  - Journal of Gender-Specific Medicine
JF  - Journal of Gender-Specific Medicine
JA  - J GENDER SPECIFIC MED
VL  - 1
IS  - 1
CY  - Malvern, Pennsylvania
PB  - MultiMedia HealthCare
SN  - 1523-7036
AD  - Director, Office of Research on Women's Health, Bldg 1, Room 201, National Institutes of Health, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Trempus, Carol S.
AU  - Mahler, Joel F.
AU  - Ananthaswamy, Honnavara N.
AU  - Loughlin, Susan M.
AU  - French, John E.
AU  - Tennant, Raymond W.
T1  - Photocarcinogenesis and Susceptibility to UV Radiation in the v‐Ha‐ras Transgenic Tg.AC Mouse.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/09//
VL  - 111
IS  - 3
M3  - Article
SP  - 445
EP  - 451
SN  - 0022202X
AB  - The v‐Ha‐ras transgenic Tg.AC mouse line has proven to be a useful model for the study of chemical carcinogenic potential. We undertook experiments designed to study the effect of the physical carcinogen, UV radiation, on tumorigenesis in this mouse strain. Following a total of three exposures on alternating days to a radiation source covering a cumulative UVR exposure range of 2.6–42.6 kJ per m2, squamous papillomas developed by 4 wk after initial exposure in a dose‐dependent manner. Malignancies developed within 18–30 wk following the initial UVR exposure and were all diagnosed as squamous cell carcinoma or spindle cell tumors. In contrast to other mouse stains used in photocarcinogenesis studies, few p53 mutations were found in Tg.AC malignancies upon polymerase chain reaction‐single stranded conformational polymorphism analysis of exons 4–8 followed by sequencing of suspicious bands; however, all tumors analyzed by in situ hybridization expressed the v‐Ha‐ras transgene. Immunohistochemical analysis of UVR‐exposed skin taken 24 h after the last of three exposures (13.1 kJ per m2 total UVR) showed expression of p53 in hair follicles and in interfollicular epidermis, which indicates that the gene was functional. Thus, although there are some differences between the Tg.AC and other mouse models, these results suggest that the Tg.AC mouse may be a useful model for the study of acute exposure photocarcinogenesis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TRANSGENIC mice
KW  - CARCINOGENESIS
KW  - PAPILLOMA
N1  - Accession Number: 5464751; Trempus, Carol S. 1 Mahler, Joel F. 1,2 Ananthaswamy, Honnavara N. 1,3 Loughlin, Susan M. 1,3 French, John E. 1 Tennant, Raymond W. 1; Affiliation:  1: Laboratories of Environmental Carcinogenesis and Mutagenesis and  2: Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S.A.;  3: The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.; Source Info: Sep98, Vol. 111 Issue 3, p445; Subject Term: TRANSGENIC mice; Subject Term: CARCINOGENESIS; Subject Term: PAPILLOMA; Number of Pages: 7p; Illustrations: 10 Color Photographs, 3 Black and White Photographs, 3 Charts, 1 Graph; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00237.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107185335
T1  - Racial differences in muscle strength in disabled older women.
AU  - Rantanen T
AU  - Guralnik JM
AU  - Leveille S
AU  - Izmirlian G
AU  - Hirsch R
AU  - Simonsick E
AU  - Ling S
AU  - Fried LP
Y1  - 1998/09//
N1  - Accession Number: 107185335. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 9502837. 
KW  - Muscle Strength -- In Old Age
KW  - Disabled -- In Old Age
KW  - Race Factors
KW  - Neuropsychological Tests
KW  - Blacks
KW  - Whites
KW  - Grip Strength
KW  - Flexion
KW  - Extension
KW  - Prospective Studies
KW  - Interrater Reliability
KW  - Hip -- Physiology
KW  - Knee -- Physiology
KW  - Hand -- Physiology
KW  - Chi Square Test
KW  - T-Tests
KW  - Pearson's Correlation Coefficient
KW  - Two-Way Analysis of Variance
KW  - Descriptive Statistics
KW  - P-Value
KW  - Analysis of Covariance
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - B355
EP  - 61
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 53A
IS  - 5
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Gateway Bldg., Suite 3C-309, Bethesda, MD 20892; e-mail: rantanet@gw.nih.gov
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - McLaughlin, Joseph K.
AU  - Lipworth, Loren
AU  - Chow, Wong-Ho
AU  - Blot, William J.
T1  - Analgesic use and chronic renal failure: A critical review of the epidemiologic literature.
JO  - Kidney International
JF  - Kidney International
Y1  - 1998/09//
VL  - 54
IS  - 3
M3  - Article
SP  - 679
EP  - 686
SN  - 00852538
AB  - Analgesic use and chronic renal failure: A critical review of the epidemiologic literature. Heavy use of analgesics, particularly over-the-counter (OTC) products, has long been associated with chronic renal failure. Most of the earlier reports implicated phenacetin-containing analgesics as the risk factor. Since the early 1980s, several case-control studies have reported associations between chronic renal failure and use of other forms of analgesics, including acetaminophen, aspirin, and other non-steroidal anti-inflammatory drugs (NSAIDs). Findings from these studies, however, should be interpreted with caution because of a number of inherent limitations and potential biases in the study design and data collection procedures. These limitations include: failure to identify patients early enough in the natural history of their disease to collect reliable information on analgesic use at an etiologically relevant time period; selection bias due to incomplete identification of subjects or low response rates; selection of cases and controls from different population bases; failure to employ survey techniques to improve reliability of recall of analgesic use; failure to collect detailed information on analgesic use such as year started and ended and reasons for switching analgesics; lack of standardization in the definition of regular analgesic use; and failure to adjust for phenacetin use and other confounding factors when assessing associations with analgesics other than those containing phenacetin. It is our hope that this review of study design limitations will lead to improvements in future studies of chronic renal failure risk. Since use of analgesics is widespread and new OTC products are introduced frequently, the potential impact of these drugs on the development of chronic renal failure may be significant, thus warranting continued evaluation of these products for any renal toxicity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANALGESICS
KW  - CHRONIC kidney failure
KW  - acetaminophen
KW  - analgesics
KW  - chronic renal failure
KW  - epidemiology
KW  - non-steroidal anti-inflammatory drugs
KW  - NSAIDs
KW  - Phenacetin
N1  - Accession Number: 5878299; McLaughlin, Joseph K. 1,2,3 Lipworth, Loren 1,2,3 Chow, Wong-Ho 1,2,3 Blot, William J. 1,2,3; Affiliation:  1: International Epidemiology Institute, Rockville, Maryland,  2: Mount Sinai School of Medicine, Department of Community Medicine, New York, New York,  3: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA; Source Info: Sep1998, Vol. 54 Issue 3, p679; Subject Term: ANALGESICS; Subject Term: CHRONIC kidney failure; Author-Supplied Keyword: acetaminophen; Author-Supplied Keyword: analgesics; Author-Supplied Keyword: chronic renal failure; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: non-steroidal anti-inflammatory drugs; Author-Supplied Keyword: NSAIDs; Author-Supplied Keyword: Phenacetin; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
L3  - 10.1046/j.1523-1755.1998.00043.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107291994
T1  - Managing hypertensive urgencies in primary care.
AU  - Currey R
Y1  - 1998/09//1998 Sep-Oct
N1  - Accession Number: 107291994. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Hypertensive Crisis -- Diagnosis
KW  - Hypertensive Crisis -- Drug Therapy
KW  - Antihypertensive Agents -- Administration and Dosage
KW  - Primary Health Care
KW  - Physical Therapy Assessment
KW  - After Care
KW  - Antihypertensive Agents -- Adverse Effects
KW  - Nifedipine
SP  - 498
EP  - 504
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 2
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Office of Science Education, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9791387.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kuroiwa, T.
AU  - Lee, E.G.
T1  - Cellular interactions in the pathogenesis of lupus nephritis: The role of T cells and macrophages in the amplification of the inflammatory process in the kidney.
JO  - Lupus
JF  - Lupus
Y1  - 1998/09//
VL  - 7
IS  - 9
M3  - Article
SP  - 597
EP  - 603
PB  - Sage Publications Inc.
SN  - 09612033
AB  - A significant number of T cells and macrophages infiltrate the kidneys of patients with lupus nephritis. Chemotactic factors, especially monocyte chemoattractant factor-1 (MCP-1) and adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), cooperatively facilitate recruitment of mononuclear cells into inflamed tissue. Increased expression of class II MHC molecules and CD40 on renal tubular epithelial cells coupled with upregulation of CD40 ligand (CD40L) and interleukin-2 receptor on infiltrating T cells suggest ongoing cellular immune responses. Recent studies employing knockout mice suggest that the T[sub H]-1 cytokine interferon-γ is an important cytokine in amplifying the local immune response of lupus nephritis. Infiltrating mononuclear cells exert their effects on resident renal cells through secretion of soluble factors and/or direct cell to cell contact. These interactions, among others, involve molecules such as CD40/CD40L and adhesion molecules. Studies to better define these molecules are in progress and may provide additional targets for therapeutic intervention. Thus, while autoantibody production and complement activation are the major players in initiating the inflammatory response in lupus nephritis, cellular immune mechanisms mediated through infiltrating mononuclear cells have an important role in its amplification and the progression of renal injury. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KIDNEYS
KW  - INTERLEUKIN-2
KW  - T cells
KW  - CELL adhesion molecules
KW  - LUPUS nephritis
KW  - PATIENTS
KW  - CYTOLOGY
KW  - CD40 ligand
KW  - Cell contact
KW  - intercellular adhesion molecule-1
KW  - monocyte chemoattractant protein-1
KW  - Th1 cytokine
N1  - Accession Number: 5004044; Kuroiwa, T. 1 Lee, E.G. 1; Affiliation:  1: National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Arthritis and Rheumatism Branch, Bethesda, Maryland, USA; Source Info: 1998, Vol. 7 Issue 9, p597; Subject Term: KIDNEYS; Subject Term: INTERLEUKIN-2; Subject Term: T cells; Subject Term: CELL adhesion molecules; Subject Term: LUPUS nephritis; Subject Term: PATIENTS; Subject Term: CYTOLOGY; Author-Supplied Keyword: CD40 ligand; Author-Supplied Keyword: Cell contact; Author-Supplied Keyword: intercellular adhesion molecule-1; Author-Supplied Keyword: monocyte chemoattractant protein-1; Author-Supplied Keyword: Th1 cytokine; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Grande, J.P.
AU  - Balow, J.E.
T1  - Renal biopsy in lupus nephritis.
JO  - Lupus
JF  - Lupus
Y1  - 1998/09//
VL  - 7
IS  - 9
M3  - Article
SP  - 611
EP  - 617
PB  - Sage Publications Inc.
SN  - 09612033
AB  - Renal biopsy can be extremely valuable in the management of patients with lupus nephritis. It is remarkably common to find pathological evidence of substantial nephron loss in patients with low-grade laboratory abnormalities. This is due to compensatory hypertrophy and hemodynamic adjustments within the less-diseased nephron mass. It has been shown that the decision to institute immunosuppressive therapy is highly informed by the results of renal biopsy and offers the prospect of achieving more favorable renal outcomes. Kidney biopsies should be evaluated by dedicated renal pathology services experienced in diagnostic light, immunofluorescence and electron microscopy. Biopsies should be classified according to the World Health Organization (WHO) system and specific lesions semiquantitatively scored against a checklist of features comprising activity (reversible) and chronicity (irreversible damage) indices. The renal biopsy findings should be reviewed jointly by pathologists and the clinicians caring for patients with lupus nephritis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RENAL biopsy
KW  - LUPUS nephritis
KW  - TREATMENT
KW  - glomerulonephritis
KW  - lupus nephritis
KW  - renal biopsy
KW  - Renal pathology
N1  - Accession Number: 5004042; Grande, J.P. 1 Balow, J.E. 2; Affiliation:  1: Mayo Foundation, Division of Nephrology, Department of Internal Medicine and Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Rochester, Minnesota  2: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Kidney Disease Section, Bethesda, Maryland, USA; Source Info: 1998, Vol. 7 Issue 9, p611; Subject Term: RENAL biopsy; Subject Term: LUPUS nephritis; Subject Term: TREATMENT; Author-Supplied Keyword: glomerulonephritis; Author-Supplied Keyword: lupus nephritis; Author-Supplied Keyword: renal biopsy; Author-Supplied Keyword: Renal pathology; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Austin, H.A.
T1  - Clinical evaluation and monitoring of lupus kidney disease.
JO  - Lupus
JF  - Lupus
Y1  - 1998/09//
VL  - 7
IS  - 9
M3  - Article
SP  - 618
EP  - 621
PB  - Sage Publications Inc.
SN  - 09612033
AB  - Lupus renal involvement encompasses a broad range of clinical and histologic presentations and poses numerous therapeutic challenges. Accurate clinical assessment and monitoring requires a comprehensive approach, with attention to the urinalysis, the urinary protein excretion rate, the test of kidney function, and alterations in serologic parameters. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KIDNEY diseases -- Diagnosis
KW  - LUPUS erythematosus
KW  - KIDNEY function tests
KW  - URINALYSIS
KW  - Glomerular filtration rate
KW  - KIDNEY FUNCTION TESTS
KW  - lupus nephritis
KW  - proteinuria
N1  - Accession Number: 5004041; Austin, H.A. 1; Affiliation:  1: National Institutes of Health, Kidney Disease Section, Bethesda, Maryland, USA; Source Info: 1998, Vol. 7 Issue 9, p618; Subject Term: KIDNEY diseases -- Diagnosis; Subject Term: LUPUS erythematosus; Subject Term: KIDNEY function tests; Subject Term: URINALYSIS; Author-Supplied Keyword: Glomerular filtration rate; Author-Supplied Keyword: KIDNEY FUNCTION TESTS; Author-Supplied Keyword: lupus nephritis; Author-Supplied Keyword: proteinuria; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Boumpas, D.T.
AU  - Balow, J.E.
T1  - Outcome criteria for lupus nephritis trials: A critical overview.
JO  - Lupus
JF  - Lupus
Y1  - 1998/09//
VL  - 7
IS  - 9
M3  - Article
SP  - 622
EP  - 629
PB  - Sage Publications Inc.
SN  - 09612033
AB  - Lupus nephritis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. Traditional outcome criteria such as doubling of serum creatinine, end-stage renal disease and death have been used in controlled therapeutic trials, but are limited by their low incidence and the extended period of time required to reach them. More recently, discussions have focused on composite outcome measures, such as remission and relapse, as well as measures of health-related quality of life, general lupus activity and cumulative damage indexes. We review the strengths and weaknesses of several outcome criteria, and we propose criteria for both small pilot studies and large definitive trials. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SYSTEMIC lupus erythematosus
KW  - LUPUS nephritis
KW  - OUTCOME assessment (Medical care)
KW  - hematuria
KW  - proteinuria
KW  - relapse
KW  - remission
KW  - serology
N1  - Accession Number: 5004040; Boumpas, D.T. 1 Balow, J.E. 1; Affiliation:  1: National Institutes of Health, Clinical Investigations Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Kidney Disease Section, National Institute of Diabetes and Digestive and Kidne; Source Info: 1998, Vol. 7 Issue 9, p622; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: LUPUS nephritis; Subject Term: OUTCOME assessment (Medical care); Author-Supplied Keyword: hematuria; Author-Supplied Keyword: proteinuria; Author-Supplied Keyword: relapse; Author-Supplied Keyword: remission; Author-Supplied Keyword: serology; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Illei, G.G.
AU  - Klippel, J.H.
T1  - Novel approaches in the treatment of lupus nephritis.
JO  - Lupus
JF  - Lupus
Y1  - 1998/09//
VL  - 7
IS  - 9
M3  - Article
SP  - 644
EP  - 648
PB  - Sage Publications Inc.
SN  - 09612033
AB  - Lupus nephritis can be managed successfully in the majority of cases; most therapies, however, are associated with significant side-effects. Several new agents aiming at specific stages in the pathogenesis of lupus are in different phases of clinical trials. The central role of lymphocytes makes them targets of various therapeutic approaches. Lymphocyte depletion can be achieved by high-dose chemotherapy with or without bone marrow transplantation. Nucleoside analogs selectively deplete mononuclear cells; antibodies against T or B cell surface antigens target specific subsets of lymphocytes. Synchronized plasmapheresis has been used in an attempt to delete pathogenic lymphocyte clones activated by plasmapheresis. Treating patients with DNase or neutralizing pathogenic antibodies by administering specific binding peptides or inducing specific anti-idiotype antibodies may prevent immune complex formation and/or deposition. Blocking the complement cascade or some of the inflammatory mediators like thromboxane A[sub 2] may be efficacious even if immune complex deposition could not be prevented. Inducing antigen-specific tolerance or interfering with important interactions between T-lymphocytes and other cells by blocking CD40 ligand or decreasing the level of interleukin-10 are some of the other approaches currently under clinical investigation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LUPUS nephritis
KW  - LYMPHOCYTES
KW  - PLASMAPHERESIS
KW  - TREATMENT
KW  - biological products
KW  - clinical trial
KW  - human
KW  - Systemic lupus erythematosus
KW  - therapy
N1  - Accession Number: 5004036; Illei, G.G. 1 Klippel, J.H. 1; Affiliation:  1: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Arthritis and Rheumatism Branch, Bethesda, Maryland, USA; Source Info: 1998, Vol. 7 Issue 9, p644; Subject Term: LUPUS nephritis; Subject Term: LYMPHOCYTES; Subject Term: PLASMAPHERESIS; Subject Term: TREATMENT; Author-Supplied Keyword: biological products; Author-Supplied Keyword: clinical trial; Author-Supplied Keyword: human; Author-Supplied Keyword: Systemic lupus erythematosus; Author-Supplied Keyword: therapy; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Crane, M.
AU  - Pucino, F.
AU  - Sebring, N.
AU  - Irby, D.
AU  - Perry, M.
AU  - Mattiko, M.
AU  - Yarboro, C.
T1  - The interdisciplinary team’s approach to lupus nephritis.
JO  - Lupus
JF  - Lupus
Y1  - 1998/09//
VL  - 7
IS  - 9
M3  - Article
SP  - 660
EP  - 665
PB  - Sage Publications Inc.
SN  - 09612033
AB  - The interdisciplinary team approach in assessment and treatment of patients with chronic disease in general and lupus nephritis in particular provides a global format for identifying the multiple problem areas that retard or prevent optimal patient functioning. These areas include the physical, emotional, economic, psychosocial, and functional. Benefits to the individual patient include a thorough multifaceted assessment by professionals who have the benefit of peer collaboration and validation. This increases the likelihood that the whole patient is considered, not just the problem of nephritis. For example, how does the patient and her or his family cope with the impact of such a disease and how, in turn, do the coping abilities of the patient and family affect the disease. The interdisciplinary team also assesses how the treatment strategies for each problem area influence each other. Finally, the interdisciplinary team serves as a positive role model for effective collaboration among health professionals and for students in their respective disciplines. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHRONICALLY ill -- Care
KW  - LUPUS nephritis
KW  - DISEASE management
KW  - INTERDISCIPLINARY research
KW  - TREATMENT
KW  - chronic disease
KW  - Interdisciplinary team
KW  - lupus nephritis
N1  - Accession Number: 5004033; Crane, M. 1 Pucino, F. 2 Sebring, N. 3 Irby, D. 4 Perry, M. 5 Mattiko, M. 5 Yarboro, C. 1; Affiliation:  1: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Arthritis and Rheumatism Branch  2: Warren Grant Magnuson, Clinical Center, National Institutes of Health, Departments of Clinical Immunology and Pharmacy, Bethesda, Maryland, USA  3: Warren Grant Magnuson, Clinical Center, National Institutes of Health, Nutrition Department, Bethesda, Maryland, USA  4: Warren Grant Magnuson, Clinical Center, National Institutes of Health, Social Work Department, Bethesda, Maryland, USA  5: Warren Grant Magnuson, Clinical Center, National Institutes of Health, Rehabilitation Medicine Department, Bethesda, Maryland, USA; Source Info: 1998, Vol. 7 Issue 9, p660; Subject Term: CHRONICALLY ill -- Care; Subject Term: LUPUS nephritis; Subject Term: DISEASE management; Subject Term: INTERDISCIPLINARY research; Subject Term: TREATMENT; Author-Supplied Keyword: chronic disease; Author-Supplied Keyword: Interdisciplinary team; Author-Supplied Keyword: lupus nephritis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104799106
T1  - Aspergillus nidulans infection in chronic granulomatous disease.
AU  - Segal, B H
AU  - DeCarlo, E S
AU  - Kwon-Chung, K J
AU  - Malech, H L
AU  - Gallin, J I
AU  - Holland, S M
Y1  - 1998/09//1998 Sep
N1  - Accession Number: 104799106. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R. 
KW  - Aspergillosis -- Complications
KW  - Aspergillus
KW  - Granuloma -- Complications
KW  - Adolescence
KW  - Adult
KW  - Aspergillosis -- Diagnosis
KW  - Aspergillosis -- Therapy
KW  - Child
KW  - Child, Preschool
KW  - Male
SP  - 345
EP  - 354
JO  - Medicine
JF  - Medicine
JA  - MEDICINE
VL  - 77
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Chronic granulomatous disease (CGD) is a rare inherited disorder of the NADPH oxidase complex in which phagocytes are defective in generating reactive oxidants. As a result, patients with CGD suffer from recurrent bacterial and fungal infections. The most common fungal infections are caused by Aspergillus species. Aspergillus nidulans is a rare pathogen in most patient populations with quantitative or qualitative neutrophil defects. We have reviewed all cases in which A. nidulans was isolated from patients at the National Institutes of Health (Bethesda, MD) between 1976 and 1997. A. nidulans infection occurred in 6 patients with CGD, but was not a pathogen in any other patient group. Aspergillus fumigatus was a more common pathogen in CGD compared with A. nidulans, but A. nidulans was more virulent. A. nidulans was significantly more likely to result in death compared with A. fumigatus, to involve adjacent bone, and to cause disseminated disease. Patients with A. nidulans received longer courses of amphotericin B therapy than patients with A. fumigatus, and were treated with surgery more often. In contrast to A. fumigatus, A. nidulans was generally refractory to intensive antifungal therapy, suggesting that early surgery may be important. These data show that A. nidulans is a distinct pathogen in CGD and its isolation carries more severe implications than that of A. fumigatus.
SN  - 0025-7974
AD  - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1886, USA.
U2  - PMID: 9772923.
DO  - 10.1097/00005792-199809000-00004
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107183769
T1  - Phonophoresis versus ultrasound in the treatment of common musculoskeletal conditions.
AU  - Klaiman MD
AU  - Shrader JA
AU  - Danoff JV
AU  - Hicks JE
AU  - Pesce WJ
AU  - Ferland J
Y1  - 1998/09//1998 Sep
N1  - Accession Number: 107183769. Language: English. Entry Date: 19990501. Revision Date: 20150819. Publication Type: Journal Article; clinical trial; equations & formulas; pictorial; research; tables/charts. Commentary: Barry H. Is phonophoresis better than plain ultrasound in the management of musculoskeletal conditions such as tendinitis and bursitis? (EVID BASED PRACT) 1999 Jan; 2 (1): 10-insert 2p. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Physician's Global Assessment (PGA); Visual Analog Scaling. NLM UID: 8005433. 
KW  - Musculoskeletal Diseases -- Therapy
KW  - Musculoskeletal Diseases -- Drug Therapy
KW  - Ultrasonic Therapy
KW  - Ultrasonics
KW  - Antiinflammatory Agents, Steroidal -- Administration and Dosage
KW  - Administration, Transcutaneous
KW  - Pain Measurement
KW  - Analysis of Variance
KW  - Clinical Assessment Tools
KW  - Random Assignment
KW  - Double-Blind Studies
KW  - Two-Way Analysis of Variance
KW  - Repeated Measures
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 1349
EP  - 1355
JO  - Medicine & Science in Sports & Exercise
JF  - Medicine & Science in Sports & Exercise
JA  - MED SCI SPORTS EXERC
VL  - 30
IS  - 9
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - PURPOSE: The purpose of this study was to determine whether the pain response after phonophoresis (PH) differs from the pain response after ultrasound (US) alone. METHODS: Forty-nine subjects with soft tissue injuries including epicondylitis, tendinitis, and tenosynovitis were randomly assigned (double blinded technique) to PH or US treatment groups. Both groups received 8 min of continuous US at 1.5 w x cm(-2), three times per week for 3 wk. For the PH group a gel containing 0.05% fluocinonide was used as a coupling agent. An identical gel absent the steroid was used for the US group. Subjects indicated their pain level by marking on a visual analog scale (VAS) at the start of treatment and at the end of weeks 1, 2, and 3. Pressure algometry was used to note tolerance to direct pressure over the target tissue. ANOVA for repeated measures was used to analyze data. RESULTS: At the end of 3 wk of treatment, both groups combined showed a significant decrease in pain level and an increase in pressure tolerance (P < 0.05), but there were no differences between groups from the onset of treatment to the end of week 3 (VAS: US 5.5-1.9, PH 5.0-2.0; algometry (involved limb): US 4.7 lb-7.1 lb, PH 5.1 lb-6.6 lb). CONCLUSIONS: We conclude that US results in decreased pain and increased pressure tolerance in these selected soft tissue injuries. The addition of PH with fluocinonide does not augment the benefits of US used alone.
SN  - 0195-9131
AD  - Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD; E-mail: mark_klaiman@nih.gov
U2  - PMID: 9741602.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Clark, L.Scott
AU  - Hart, Daniel W.
AU  - Vojta, Patrick J.
AU  - Harrington-Brock, Karen
AU  - Barrett, J.Carl
AU  - Moore, Martha M.
AU  - Tindall, Kenneth R.
T1  - Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y\Tk +\−-3.7.2C mouse lymphoma cells.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/09//
VL  - 13
IS  - 5
M3  - Article
SP  - 427
EP  - 434
PB  - Oxford University Press / USA
SN  - 02678357
AB  - The thymidine kinase locus (Tk1) in Tk +\−-3.7.2C mouse lymphoma cells is widely used to identify mutagenic agents. Because Trp53 (the mouse homolog of human TP53) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents, we wanted to determine if these mouse lymphoma cells harbor mutations in Trp53. Single-stranded conformation polymorphism (SSCP) analysis of PCRamplified exons 4–9 of Trp53 indicated mutations in both exons 4 and 5. We sequenced exons 4–9 from isolated clones of Tk+\−-3.7.2C cells and a Tk−\− mutant (G4). Mutant G4 has two copies of the chromosome arrying the Tk1− allele and no copy of the chromosome carrying the Tk1+ allele and thus could establish linkage of the individual Trp53 and Tk1 alleles. DNA sequence analysis revealed no mutations in exons 6–9 in any Tk+\−-3.7.2C or G4 clones. As suggested by SSCP, there was a nonsense mutation in exon 4 at bp 301 (codon 101) in one Trp53 allele. Tk+\−-3.7.2C clones have both mutant and wild-type sequences at bp 301; G4 clones have wild-type exon 4 sequence. These data allow assignment of the Trp53 exon 4 mutated allele to chromosome 11 carrying the Tk1+ allele. The exon 4 mutation leads to a stop codon early in translation, thus functionally deleting the Trp53 allele on the +\–bearing chromosome. As previously reported, we find a missense mutation in exon 5 at bp 517 (codon 173) in one Trp53 allele. Using the G4 clones we determined that the exon 5 mutation is linked to the Tk1− allele. Thus the Tk+\−-3.7.2C mouse lymphoma cells have two mutant Trp53 alleles, likely accounting for their rapid cell growth and contributing to their ability to detect the major types of mutational damage associated with the etiology of tumor development. This ability to integrate across the mutational events seen in the multiple stages of tumor development further supports the use of the assay in chemical and drug safety studies and its recommendation as part of the required screening battery for regulatory agency submissions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutation (Biology)
KW  - DNA damage
KW  - Chromosomes
KW  - Genes
KW  - T-cell lymphoma
KW  - Conformational analysis
KW  - Genetic polymorphisms
KW  - Mice as laboratory animals
N1  - Accession Number: 79237986; Clark, L.Scott 1; Hart, Daniel W. 2; Vojta, Patrick J. 3; Harrington-Brock, Karen 4; Barrett, J.Carl 3; Moore, Martha M. 4; Tindall, Kenneth R. 2; Affiliations: 1: Curriculum in Toxicology, University of North Carolina Chapel Hill, NC; 2: laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences Research Triangle Park, NC, USA; 3: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences Research Triangle Park, NC, USA; 4: Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory.US Environmental Protection Agency Research Triangle Park, NC, USA; Issue Info: Sep1998, Vol. 13 Issue 5, p427; Thesaurus Term: Mutation (Biology); Thesaurus Term: DNA damage; Subject Term: Chromosomes; Subject Term: Genes; Subject Term: T-cell lymphoma; Subject Term: Conformational analysis; Subject Term: Genetic polymorphisms; Subject Term: Mice as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Liechty, Melissa C.
AU  - Scalzi, Jane M.
AU  - Sims, Kenneth R.
AU  - Crosby, Herbert
AU  - Spencer, Diane L.
AU  - Davis, Lisa M.
AU  - Caspary, William J.
AU  - Hozier, John C.
T1  - Analysis of large and small colony L5178Y tk−\− mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/09//
VL  - 13
IS  - 5
M3  - Article
SP  - 461
EP  - 474
PB  - Oxford University Press / USA
SN  - 02678357
AB  - Analysis of 122 spontaneous large and small colony mutants derived from L5178Y tk+/−mouse lymphoma cells at 28 heteromorphic microsatellite loci on chromosome 11 showed that extensive loss of heterozygosity (LOH) is common in both large colony and small colony mutants, eliminating most chromosome 11 loci as candidates for a putative growth control locus. These results, in conjunction with historical cytogenetic data, suggest that a putative growth control locus lies distal to the thymidine kinase (Tk1) gene, near the telomere. Thirty seven mutants were hybridized with a chromosome 11-specific whole chromosome painting probe for analysis of rearrangements. Generally, painting confirmed earlier observations that large colony mutants are karyotypically normal, whereas small colony mutants frequently have detectable rearrangements. A point probe distal to Tk1revealed no evidence of chromosome breakage in small colony mutants that appeared normal on whole 11 painting and had no LOH. Therefore, the molecular difference between large and small colony mutants remains unknown. Models to explain large and small colony mutants consistent with our findings are presented, including loss of a putative growth control gene, differential mechanisms of chromosome breakage/repair and second site mutations as planations for small colony mutants. Painting revealed translocations and aneuploidy and showed that non-disjunction was not a common explanation for complete LOH. The most common finding was that large regions of LOH do not result from deletions, demonstrating that these cells can detect recombination events as well as previously observed chromosomal rearrangements, deletions and point mutations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cytogenetics
KW  - Lymphomas
KW  - Mice as laboratory animals
KW  - Heterozygosity
KW  - Chromosomes
KW  - T-cell lymphoma
KW  - Aneuploidy
N1  - Accession Number: 79237990; Liechty, Melissa C. 1; Scalzi, Jane M. 1; Sims, Kenneth R. 1; Crosby, Herbert 1; Spencer, Diane L. 2; Davis, Lisa M. 1; Caspary, William J. 2; Hozier, John C. 1; Affiliations: 1: Applied Genetics Laboratories Inc. 1335 Gateway Drive, Suite 2001, Melbourne, FL 32901, USA; 2: Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health Research Triangle Park, NC 27709, USA; Issue Info: Sep1998, Vol. 13 Issue 5, p461; Thesaurus Term: Cytogenetics; Subject Term: Lymphomas; Subject Term: Mice as laboratory animals; Subject Term: Heterozygosity; Subject Term: Chromosomes; Subject Term: T-cell lymphoma; Subject Term: Aneuploidy; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Watson, David E.
AU  - L.Cunningham, Michael
AU  - R-Tindall, Kenneth
T1  - Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue® Rat2 embryonic fibroblasts.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/09//
VL  - 13
IS  - 5
M3  - Article
SP  - 487
EP  - 497
PB  - Oxford University Press / USA
SN  - 02678357
AB  - Big Blue® Rat2 embryonic fibroblasts carry the λ-Liz shuttle vector which is also present in the Big Blue® mouse and rat. Mutations in the Big Blue®. systems have most often been measured at the lacI locus. However, a method for positive selection of mutations at the λ cII locus was recently described. This assay appears to have many advantages over the use of lacI as a mutational target, but it has yet to be well characterized in mammalian mutagenesis studies. The objective of these studies was to determine the spontaneous and ethylnitrosourea (ENU)-induced mutant frequencies (MFs) and mutational spectra at cII using Big Blue® Rat2 embryonic fibroblasts. The average spontaneous MF was 13 ± 1.4 × 10−5. The average induced MF was 60 ± 10 × 10−510 days following a 30 min treatment with 0.1 mg/ml ENU. Eighty four independent spontaneous mutants were sequenced: 23 (27.4%) were frameshift mutations and 61 (72.6%) were base substitutions. Two spontaneous frameshift hotspots were detected, both in mononucleotide runs. G:C→A:T transitions were the most common type of base substitution in cII; of these 71 % occurred at CpG sites. The ENU-induced mutational spectrum at cII (44 mutants) consisted of 42 base substitutions (95.5%) and two -1 frameshift mutations (4.5%). Compared with the spontaneous spectrum, the ENU-induced spectrum had significantly fewer frameshift mutations (4.5 versus 27%) and base substitutions occurred predominantly at A:T base pairs (71 versus 34%). Overall, the spontaneous cII mutational spectrum reported here differs slightly from spontaneous spectra reported at the Big Blue® lacl locus, but the mutational spectra and base substitution MFs following treatment with ENU were comparable at both loci. These data support the continued use of cII as a selectable marker in mutagenesis studies involving cells or tissues that carry a λ transgene. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Mutation (Biology)
KW  - Rats as laboratory animals
KW  - Fibroblasts
KW  - Ethylnitrosourea
KW  - Transgenes
KW  - Frameshift mutation
KW  - CPG nucleotides
N1  - Accession Number: 79237996; Watson, David E. 1,2; L.Cunningham, Michael 2; R-Tindall, Kenneth 1; Affiliations: 1: Molecular Mutagenesis Group, Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709, USA; 2: Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709, USA; Issue Info: Sep1998, Vol. 13 Issue 5, p487; Thesaurus Term: Mutation (Biology); Subject Term: Rats as laboratory animals; Subject Term: Fibroblasts; Subject Term: Ethylnitrosourea; Subject Term: Transgenes; Subject Term: Frameshift mutation; Subject Term: CPG nucleotides; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Chandra, P. S.
AU  - Chaturvedi, S. K.
AU  - Channabasavanna, S. M.
AU  - Anantha, N.
AU  - Reddy, B. K. M.
AU  - Sharma, S.
AU  - Rao, S.
T1  - Psychological well-being among cancer patients receiving radiotherapy –a prospective study.
JO  - Quality of Life Research
JF  - Quality of Life Research
Y1  - 1998/09//
VL  - 7
IS  - 6
M3  - Article
SP  - 495
EP  - 500
PB  - Springer Science & Business Media B.V.
SN  - 09629343
AB  - The impact of cancer on the psychological well-being of newly diagnosed cancer patients before and during the course of radiotherapy was assessed in 70 consecutive cancer patients. Most of the patients were over 40 years of age, women, illiterate and from a lower socioeconomic group. During the course of treatment there was a decrease in the well-being scores on some dimensions such as perceived family and primary group support. Improvements were seen in the dimensions of positive feelings, coping, social support other than the family and spiritual well-being. There were no changes in the dimensions of negative feelings and perceived ill-health. The results give a profile on well-being and the changes observed during radiotherapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Quality of Life Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER patients
KW  - CANCER -- Radiotherapy
KW  - QUALITY of life
KW  - WOMEN patients
KW  - OLDER women
KW  - quality of life.
KW  - radiotherapy
KW  - Well-being
N1  - Accession Number: 11501148; Chandra, P. S. 1; Email Address: chandra@nimhans.ren.nic.in Chaturvedi, S. K. 1 Channabasavanna, S. M. 1 Anantha, N. 2 Reddy, B. K. M. 2 Sharma, S. 2 Rao, S. 1; Affiliation:  1: National Institute of Mental Health and Neurosciences, Bangalore, India  2: Department of Radiotherapy, Kidwai Memorial Institute of Oncology, Bangalore, India; Source Info: Sep1998, Vol. 7 Issue 6, p495; Subject Term: CANCER patients; Subject Term: CANCER -- Radiotherapy; Subject Term: QUALITY of life; Subject Term: WOMEN patients; Subject Term: OLDER women; Author-Supplied Keyword: quality of life.; Author-Supplied Keyword: radiotherapy; Author-Supplied Keyword: Well-being; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107220824
T1  - Pneumatic compression devices for lymphedema.
AU  - McGarvey CL
Y1  - 1998/09//
N1  - Accession Number: 107220824. Language: English. Entry Date: 19991101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA. 
KW  - Lymphedema
KW  - Compression Therapy -- Equipment and Supplies
KW  - Compression Garments
SP  - 28
EP  - 28
JO  - Rehabilitation Oncology
JF  - Rehabilitation Oncology
JA  - REHABIL ONCOL
VL  - 16
IS  - 3
CY  - Alexandria, Virginia
PB  - American Physical Therapy Association, Oncology Section
SN  - 2168-3808
AD  - Director of Physical Therapy, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Chan, P. C.
AU  - Herbert, R. A.
AU  - Roycroft, J. H.
AU  - Haseman, J. K.
AU  - Grumbein, S. L.
AU  - Miller, R. A.
AU  - Chou, B. J.
T1  - Lung Tumor Induction by Inhalation Exposure to Molybdenum Trioxide in Rats and Mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/09//
VL  - 45
IS  - 1
M3  - Article
SP  - 58
EP  - 65
SN  - 10966080
AB  - Inhalation studies of molybdenum trioxide (MoO3) were conducted because of its wide use in industry, human exposure, and lack of data on carcinogenicity. Groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to MoO3 by inhalation at 0, 10, 30, or 100 mg/m3, 6 h/day, 5 days/week, for 2 years. In both rats and mice, survival and mean body weights of exposed groups of males and females were similar to those of their respective controls. There were significant exposure-dependent increases in blood molybdenum concentration in exposed rats and mice. There were no toxicological differences in bone density or curvature between exposed animals and their respective controls. In rats, dose-dependent increases in incidence of hyaline degeneration in the nasal olfactory epithelium and squamous metaplasia of the epithelium lining the base of the epiglottis were observed. The incidence of alveolar/bronchiolar adenoma or carcinoma (combined) was marginally increased in males but not in females compared with controls. In mice, the incidences of squamous metaplasia of the epithelium lining the base of the epiglottis, hyperplasia of the laryngeal epithelium, and metaplasia of the alveolar epithelium were significantly increased in all exposed males and females compared with controls. The incidence of alveolar/bronchiolar adenoma or carcinoma (combined) in exposed groups of males and females was significantly greater than that in the control groups. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83180612; Chan, P. C. 1; Herbert, R. A. 1; Roycroft, J. H. 1; Haseman, J. K. 1; Grumbein, S. L. 2; Miller, R. A. 2; Chou, B. J. 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; 2: † Battelle Pacific Northwest Laboratories Richland, Washington 99352; Issue Info: 1998, Vol. 45 Issue 1, p58; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Rao, Ghanta N.
AU  - Lindamood, Charles
AU  - Heath, James E.
AU  - Farnell, Daniel R.
AU  - Giles, Herschell D.
T1  - Subchronic Toxicity of Human Immunodeficiency Virus and Tuberculosis Combination Therapies in B6C3F1 Mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/09//
VL  - 45
IS  - 1
M3  - Article
SP  - 113
EP  - 127
SN  - 10966080
AB  - Combination therapy with anti-HIV drugs and opportunistic infection drugs is a common practice in treatment of AIDS patients. Although toxic effects of most individual therapies are known, the toxic potential of most combination therapies has not been established. To understand the toxic consequences of combination therapies, the commonly used anti-HIV drug 3′-azido-3′-deoxythymidine (AZT) and tuberculosis infection therapies pyra-zinamide, isoniazid, and rifampicin were evaluated by 13-week gavage studies in B6C3F1 mice, either alone or AZT in combination with one of the antituberculosis drugs. The doses include AZT 100, 200, and 400; pyrazinamide 1000 and 1500; isoniazid 50,100, and 150; and rifampicin 100, 200, and 400 mg/kg/day. AZT alone caused hematopoietic toxicity with dose-related bone marrow suppression, macrocytic anemia, and thrombocytosis. Pyrazinamide or isoniazid alone at the doses tested did not cause significant toxicity. Rifampicin alone caused hematopoietic toxicity and possibly mild hepatic toxicity. Pyrazinamide below 10 times the therapeutic dose when given with AZT did not increase the hemato-logical toxicity of AZT. Isoniazid markedly increased the hematological toxicity of AZT and contributed to mortality at 3 to 4 times the therapeutic dose combinations. Administration of rifampicin with AZT at the calculated therapeutic doses resulted in toxicity of far greater magnitude than that caused by AZT or rifampicin alone. Combination treatment with AZT and rifampicin caused severe anemia with mortality at 2 to 4 times the therapeutic dose combinations. However, AZT did not enhance the hepatotoxicity of rifampicin. Increased hematopoietic toxicity of AZT when given in combination with the above antituberculosis drugs may be due to changes in the metabolism of AZT. Results of these studies indicate that toxicological effects of combination therapies could be considerably more severe than and different from the toxicity of individual therapies. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 83180607; Rao, Ghanta N. 1; Lindamood, Charles 2; Heath, James E. 2; Farnell, Daniel R. 2; Giles, Herschell D. 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park North California 27709; 2: † Southern Research Institute Birmingham, Alabama 35255; Issue Info: 1998, Vol. 45 Issue 1, p113; Number of Pages: 15p; Document Type: Article
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DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-41747-018
AN  - 2015-41747-018
AU  - Gottschalk, Wolfram
AU  - Pozzo-Miller, Lucas D.
AU  - Figurov, Alexander
AU  - Lu, Bai
T1  - Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/09//
VL  - 18
IS  - 17
SP  - 6830
EP  - 6839
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Lu, Bai, Unit on Synapse Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A38, 49 Convent Drive, Bethesda, MD, US, 20892-4480
N1  - Accession Number: 2015-41747-018. PMID: 9712654 Partial author list: First Author & Affiliation: Gottschalk, Wolfram; Unit on Synapse Development and Plasticity, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hippocampus; Brain Derived Neurotrophic Factor; Long-term Potentiation. Minor Descriptor: Neural Receptors; Neurotransmission; Rats; Synaptic Plasticity. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 1998. Publication History: Accepted Date: Jun 23, 1998; Revised Date: Jun 9, 1998; First Submitted Date: Apr 10, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - In addition to the regulation of neuronal survival and differentiation, neurotrophins may play a role in synapse development and plasticity. Application of brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) in CA1 synapses of neonatal hippocampus, which otherwise exhibit only shortterm potentiation. This is attributable, at least in part, to an attenuation of the synaptic fatigue induced by high-frequency stimulation (HFS). However, the prevention of synaptic fatigue by BDNF could be mediated by an attenuation of synaptic vesicle depletion from presynaptic terminals and/or a reduction of the desensitization of postsynaptic receptors. Here we provide evidence supporting a presynaptic effect of BDNF. The effect of BDNF on synaptic fatigue depended on the stimulation frequency, not on the stimulus duration nor on the number of stimulation pulses. BDNF was only effective when the synapses were stimulated at frequencies > 50 Hz. Treatment with BDNF also potentiated paired-pulse facilitation (PPF), a parameter reflecting changes in the properties of presynaptic terminals. This effect of BDNF was restricted only to PPF elicited with interpulse intervals ≤ 20 msec. Changes in the extracellular calcium concentration altered the magnitude of the BDNF effect on PPF and synaptic responses to HFS, suggesting that BDNF regulates neurotransmitter release. When the desensitization of glutamate receptors was blocked by cyclothiazide or aniracetam, the BDNF potentiation of the synaptic responses to HFS was unaltered. Taken together, these results suggest that BDNF acts presynaptically. When two pathways in the same slice were monitored simultaneously, BDNF treatment potentiated the tetanized pathway without affecting the synaptic efficacy of the untetanized pathway. The selective potentiation of highfrequency transmission by BDNF appears to contribute directly to the effect of BDNF on LTP rather than indirectly by inducing the release of additional diffusible factors. The preferential potentiation of highly active synapses by BDNF may have implications in the Hebbian mechanism of synaptic plasticity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - BDNF
KW  - presynaptic
KW  - hippocampus
KW  - LTP
KW  - synaptic fatigue
KW  - plasticity
KW  - 1998
KW  - Hippocampus
KW  - Brain Derived Neurotrophic Factor
KW  - Long-term Potentiation
KW  - Neural Receptors
KW  - Neurotransmission
KW  - Rats
KW  - Synaptic Plasticity
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41747-028
AN  - 2015-41747-028
AU  - Ziemann, Ulf
AU  - Hallett, Mark
AU  - Cohen, Leonardo G.
T1  - Mechanisms of deafferentation-induced plasticity in human motor cortex.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/09//
VL  - 18
IS  - 17
SP  - 7000
EP  - 7007
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ziemann, Ulf, National Institutes of Health, Building 10, Room 5N234, 10 Center Drive, MSC-1428, Bethesda, MD, US, 20892-1428
N1  - Accession Number: 2015-41747-028. PMID: 9712668 Partial author list: First Author & Affiliation: Ziemann, Ulf; Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ziemann, Ulf. Major Descriptor: Glutamate Receptors; N-Methyl-D-Aspartate; Transcranial Magnetic Stimulation; Synaptic Plasticity. Minor Descriptor: Motor Cortex; Long-term Potentiation. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 1998. Publication History: Accepted Date: Jun 15, 1998; Revised Date: Jun 10, 1998; First Submitted Date: Apr 6, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Deafferentation induces rapid plastic changes in the cerebral cortex, probably via unmasking of pre-existent connections. Several mechanisms may contribute, such as changes in neuronal membrane excitability, removal of local inhibition, or various forms of short- or long-term synaptic plasticity. To understand further the mechanisms involved in cortical plasticity, we tested the effects of CNS-active drugs in a plasticity model, in which forearm ischemic nerve block (INB) was combined with low-frequency repetitive transcranial magnetic stimulation (rTMS) of the deafferented human motor cortex. rTMS was used to upregulate the plastic changes caused by INB. We studied six healthy subjects. In two control sessions without drug application, INB plus rTMS increased the motor-evoked potential (MEP) size and decreased intracortical inhibition (ICI) measured with single- and paired-pulse TMS in the biceps brachii muscle proximal to INB. A single oral dose of the benzodiazepine lorazepam (2 mg) or the voltage-gated Na+ and Ca2+ channel blocker lamotrigine (300 mg) abolished these changes. The NMDA receptor blocker dextromethorphan (150 mg) suppressed the reduction in ICI but not the increase in MEP size. With sleep deprivation, used to eliminate sedation as a major factor of these drug effects, INB plus rTMS induced changes similar to that seen in the control sessions. The findings suggest that (1) the INB plus rTMS-induced increase in MEP size involves rapid removal of GABA-related cortical inhibition and short-term changes in synaptic efficacy dependent on Na1 or Ca21 channels and that (2) the long-lasting (.60 min) reduction in ICI is related to long-term potentiation-like mechanisms given its duration and the involvement of NMDA receptor activation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mechanisms of cortical plasticity
KW  - transient ischemic forearm deafferentation
KW  - pharmacological blockade of plasticity
KW  - GABA
KW  - glutamate
KW  - paired-pulse inhibition
KW  - human motor cortex
KW  - 1998
KW  - Glutamate Receptors
KW  - N-Methyl-D-Aspartate
KW  - Transcranial Magnetic Stimulation
KW  - Synaptic Plasticity
KW  - Motor Cortex
KW  - Long-term Potentiation
KW  - 1998
U1  - Sponsor: Deutsche Forschungsgemeinschaft, Germany. Grant: Zi 542/1-1. Recipients: Ziemann, Ulf
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41749-018
AN  - 2015-41749-018
AU  - Vicario-Abejón, Carlos
AU  - Collin, Carlos
AU  - McKay, Ronald D. G.
AU  - Segal, Menahem
T1  - Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/09//
VL  - 18
IS  - 18
SP  - 7256
EP  - 7271
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - McKay, Ronald D. G., National Institutes of Health, National Institute of Neurological Disorders and Stroke, Laboratory of Molecular Biology, Building 36, Room 3DO2, Bethesda, MD, US, 20892-4092
N1  - Accession Number: 2015-41749-018. PMID: 9736647 Partial author list: First Author & Affiliation: Vicario-Abejón, Carlos; Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gamma Aminobutyric Acid; Neural Receptors; Brain Derived Neurotrophic Factor; Neurotrophic Factor; Synaptic Plasticity. Minor Descriptor: Hippocampus; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 16. Issue Publication Date: Sep, 1998. Publication History: Accepted Date: Jul 6, 1998; Revised Date: Jun 29, 1998; First Submitted Date: Apr 20, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Cell cultures were used to analyze the role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development of synaptic transmission. Neurons obtained from embryonic day 18 (E18) rat hippocampus and cultured for 2 weeks exhibited extensive spontaneous synaptic activity. By comparison, neurons obtained from E16 hippocampus expressed very low levels of spontaneous or evoked synaptic activity. Neurotrophin treatment produced a sevenfold increase in the number of functional synaptic connections in the E16 cultures. BDNF induced formation of both excitatory and inhibitory synapses, whereas NT-3 induced formation of only excitatory synapses. These effects were independent of serum or the age of the glia bed used for the culture. They were not accompanied by significant changes in synaptic-vesicle-associated proteins or glutamate receptors. Treatment of the cultures with the neurotrophins for 3 d was sufficient to establish the maximal level of functional synapses. During this period, neurotrophins did not affect the viability or the morphology of the excitatory neurons, although they did produce an increase in the number and length of dendrites of the GABAergic neurons. Remarkably, only BDNF caused an increase in the number of axonal branches and in the total length of the axons of the GABAergic neurons. These results support a unique and differential role for neurotrophins in the formation of excitatory and inhibitory synapses in the developing hippocampus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - synapses
KW  - hippocampus
KW  - culture
KW  - BDNF
KW  - NT-3
KW  - GABA
KW  - 1998
KW  - Gamma Aminobutyric Acid
KW  - Neural Receptors
KW  - Brain Derived Neurotrophic Factor
KW  - Neurotrophic Factor
KW  - Synaptic Plasticity
KW  - Hippocampus
KW  - Rats
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Schnermann, Jürgen
AU  - Traynor, Timothy
AU  - Yang, Tianxin
AU  - Arend, Lois
AU  - Huang, Yuning G.
AU  - Smart, Ann
AU  - Briggs, Josie P.
T1  - Tubuloglomerular feedback: New concepts and developments.
JO  - Kidney International
JF  - Kidney International
Y1  - 1998/09/02/Sep1998 Supplement 67
VL  - 54
M3  - Article
SP  - S40
EP  - S45
SN  - 00852538
AB  - Tubuloglomerular feedback: New concepts and developments. Luminal [NaCl] at the macula densa (MD) has two established effects: regulation of glomerular arteriolar resistance through tubuloglomerular feedback (TGF) and control of renin secretion. TGF acts as a minute-to-minute stabilizer of distal salt delivery, thereby minimizing the impact of random perturbations in filtration and absorption forces on NaCl excretion. During long-lasting perturbations of MD [NaCl], control of renin secretion becomes the dominant function of the MD. The potentially maladaptive effect of TGF under chronic conditions is prevented by TGF adaptations permitting adjustments in glomerular filtration rate to occur. TGF adaptation is mechanistically coupled to the endpoint targeted by chronic deviations in MD [NaCl], the rate of local and systemic angiotensin II generation. Studies of TGF in transgenic mice are expected to provide further insights into the mechanisms mediating between luminal [NaCl] and afferent arterioles. TGF responses are virtually abolished in mice in which either the AT 1A gene or the angiotensin converting enzyme gene is rendered nonfunctional by homologous recombination. In contrast, TGF responses are unaltered in nitric oxide synthase I knockout mice. Thus, an intact renin-angiotensin system appears to be critical for the TGF signaling pathway. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KIDNEY tubules
KW  - KIDNEYS -- Development
KW  - KIDNEY secretions
KW  - RENIN
KW  - GLOMERULAR filtration rate
KW  - ANGIOTENSIN II
KW  - juxtaglomerular apparatus
KW  - micropuncture
KW  - nitric oxide synthase
KW  - renin-angiotensin system
KW  - transgenic mice
N1  - Accession Number: 118849363; Schnermann, Jürgen 1,2; Email Address: jbsch@umich.edu Traynor, Timothy 1,2 Yang, Tianxin 1,2 Arend, Lois 1,2 Huang, Yuning G. 1,2 Smart, Ann 1,2 Briggs, Josie P. 1,2; Affiliation:  1: Departments of Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan  2: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Sep1998 Supplement 67, Vol. 54, pS40; Subject Term: KIDNEY tubules; Subject Term: KIDNEYS -- Development; Subject Term: KIDNEY secretions; Subject Term: RENIN; Subject Term: GLOMERULAR filtration rate; Subject Term: ANGIOTENSIN II; Author-Supplied Keyword: juxtaglomerular apparatus; Author-Supplied Keyword: micropuncture; Author-Supplied Keyword: nitric oxide synthase; Author-Supplied Keyword: renin-angiotensin system; Author-Supplied Keyword: transgenic mice; Number of Pages: 1p; Document Type: Article
L3  - 10.1046/j.1523-1755.1998.06708.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - MOLLDREM, JEFFREY J.
AU  - YIN ZHENG JIANG
AU  - STETLER-STEVENSON, MARYALICE
AU  - MAVROUDIS, DIMITRIO$
AU  - HENSEL, NANCY
AU  - BARRETT, A. JOHN
T1  - Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vβ profiles.
JO  - British Journal of Haematology
JF  - British Journal of Haematology
Y1  - 1998/09/15/
VL  - 102
IS  - 5
M3  - Article
SP  - 1314
EP  - 1322
PB  - Wiley-Blackwell
SN  - 00071048
N1  - Accession Number: 23590003; MOLLDREM, JEFFREY J. 1 YIN ZHENG JIANG 2 STETLER-STEVENSON, MARYALICE 3 MAVROUDIS, DIMITRIO$ 2 HENSEL, NANCY 2 BARRETT, A. JOHN 2; Affiliation:  1: Department of Blood and Marrow Transplantation, University of Texas M. D. Andersen Cancer Center, Houston, Texas  2: Bone Marrow Transplantation Unit, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland, U.S.A  3: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep98, Vol. 102 Issue 5, p1314; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107297307
T1  - Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial.
AU  - McKenzie R
AU  - O'Fallon A
AU  - Dale J
AU  - Demitrack M
AU  - Sharma G
AU  - Deloria M
AU  - Garcia-Borreguero D
AU  - Blackwelder W
AU  - Straus SE
AU  - McKenzie, R
AU  - O'Fallon, A
AU  - Dale, J
AU  - Demitrack, M
AU  - Sharma, G
AU  - Deloria, M
AU  - Garcia-Borreguero, D
AU  - Blackwelder, W
AU  - Straus, S E
Y1  - 1998/09/23/
N1  - Accession Number: 107297307. Language: English. Entry Date: 19981101. Revision Date: 20161112. Publication Type: journal article; research; tables/charts; randomized controlled trial. Supplement Title: 9/23/98-9/30/98. Commentary: Teitelbaum J E, Bird B, Weiss A, Gould L. Low-dose hydrocortisone for chronic fatigue syndrome. (JAMA) 5/26/99; 281 (20): 1887-1888; Friedman T C, Adesanya A, Poland R E. Low-dose hydrocortisone for chronic fatigue syndrome. (JAMA) 5/26/99; 281 (20): 1888-1889. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Profile of Mood States (POMS); Beck Depression Inventory (BDI); Hamilton Rating Scale for Depression (HRDS); Symptom Checklist-90-Revised (SCL-90-R); Sickness Impact Profile (SIP); Wellness Scale. NLM UID: 7501160. 
KW  - Hydrocortisone -- Therapeutic Use
KW  - Fatigue Syndrome, Chronic -- Drug Therapy
KW  - Symptom Checklist-90-Revised
KW  - Hamilton Rating Scale for Depression
KW  - Double-Blind Studies
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Hydrocortisone -- Administration and Dosage
KW  - Treatment Outcomes
KW  - Fatigue Syndrome, Chronic -- Physiopathology
KW  - Sickness Impact Profile
KW  - Wellness
KW  - Chi Square Test
KW  - Fisher's Exact Test
KW  - Wilcoxon Rank Sum Test
KW  - Placebos
KW  - Fatigue Syndrome, Chronic -- Symptoms
KW  - Fatigue Syndrome, Chronic -- Psychosocial Factors
KW  - Hydrocortisone -- Adverse Effects
KW  - Research Instruments
KW  - Human
SP  - 1061
EP  - 1066
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 280
IS  - 12
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Chronic fatigue syndrome (CFS) is associated with a dysregulated hypothalamic-pituitary adrenal axis and hypocortisolemia.Objective: To evaluate the efficacy and safety of low-dose oral hydrocortisone as a treatment for CFS.Design: A randomized, placebo-controlled, double-blind therapeutic trial, conducted between 1992 and 1996.Setting: A single-center study in a tertiary care research institution.Patients: A total of 56 women and 14 men aged 18 to 55 years who met the 1988 Centers for Disease Control and Prevention case criteria for CFS and who withheld concomitant treatment with other medications.Intervention: Oral hydrocortisone, 13 mg/m2 of body surface area every morning and 3 mg/m2 every afternoon, or placebo, for approximately 12 weeks.Main Outcome Measures: A global Wellness scale and other self-rating instruments were completed repeatedly before and during treatment. Resting and cosyntropin-stimulated cortisol levels were obtained before and at the end of treatment. Patients recorded adverse effects on a checklist.Results: The number of patients showing improvement on the Wellness scale was 19 (54.3%) of 35 placebo recipients vs 20 (66.7%) of 30 hydrocortisone recipients (P =.31). Hydrocortisone recipients had a greater improvement in mean Wellness score (6.3 vs 1.7 points; P=.06), a greater percentage (53% vs 29%; P=.04) recording an improvement of 5 or more points in Wellness score, and a higher average improvement in Wellness score on more days than did placebo recipients (P<.001). Statistical evidence of improvement was not seen with other self-rating scales. Although adverse symptoms reported by patients taking hydrocortisone were mild, suppression of adrenal glucocorticoid responsiveness was documented in 12 patients who received it vs none in the placebo group (P<.001).Conclusions: Although hydrocortisone treatment was associated with some improvement in symptoms of CFS, the degree of adrenal suppression precludes its practical use for CFS.
SN  - 0098-7484
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1888, USA
AD  - Laboratory of Clinical Investigation and Division of Microbiology and Infectious Diseases, Bethesda, Md
U2  - PMID: 9757853.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107160375
T1  - The essence of nursing is in touching another's soul.
AU  - Loscalzo F
Y1  - 1998/10//1998 Oct
N1  - Accession Number: 107160375. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; anecdote. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. 
KW  - Critical Care Nursing
KW  - Heart Transplantation -- In Infancy and Childhood
KW  - Heart Transplantation -- Nursing
KW  - Child
SP  - 3
EP  - 6
JO  - AACN News
JF  - AACN News
JA  - AACN NEWS
VL  - 15
IS  - 10
CY  - Aliso Viejo, California
PB  - American Association of Critical-Care Nurses
AD  - Staff Nurse, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107147597
T1  - Birth weight and renal disease in Pima Indians with type 2 diabetes mellitus.
AU  - Nelson RG
AU  - Morgenstern H
AU  - Bennett PH
Y1  - 1998/10//
N1  - Accession Number: 107147597. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653. 
KW  - Birth Weight
KW  - Diabetic Nephropathies -- Epidemiology
KW  - Native Americans
KW  - Diabetes Mellitus, Type 2
KW  - Logistic Regression
KW  - Linear Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Descriptive Statistics
KW  - P-Value
KW  - Cross Sectional Studies
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 650
EP  - 656
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 148
IS  - 7
PB  - Oxford University Press / USA
AB  - Congenital retardation of renal development may increase the risk of renal disease, and this risk may be enhanced by diseases, such as diabetes, that damage the kidney. In this study, the prevalence of urinary albumin excretion, determined in 308 Pima Indians with type 2 diabetes, was 63% in subjects with low birth weight (<2,500 g), 41% in those with normal birth weight (2,500-4,499 g), and 64% in those with high birth weight (> or =4,500 g). When examined as a continuous variable by generalized additive logistic regression, birth weight had a U-shaped association with the prevalence of elevated urinary albuminuria (p = 0.04) after adjustment for age, sex, duration of diabetes, glycosylated hemoglobin, and blood pressure. The odds of elevated albuminuria in subjects of low birth weight was 2.3 times (95% confidence interval 0.72-7.2) that in subjects of normal birth weight, and the odds in subjects of high birth weight was 3.2 times (95% confidence interval 0.75-13.4) as high. Sixty-four percent of the subjects with high birth weight and none of those with low birth weight were offspring of diabetic mothers. After maternal diabetes during pregnancy was controlled for, the odds of elevated albuminuria in subjects of high birth weight was no longer higher (odds ratio = 1.0, 95% confidence interval 0.22-4.9). The higher prevalence of elevated albuminuria in diabetic Pima Indians with high birth weight may be due to intrauterine diabetes exposure, whereas the higher prevalence in those with low birth weight may be due to the effects of intrauterine growth retardation.
SN  - 0002-9262
AD  - Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014-4972
U2  - PMID: 9778171.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107147602
T1  - Foot pain and disability in older women.
AU  - Leveille SG
AU  - Guralnik JM
AU  - Ferrucci L
AU  - Hirsch R
AU  - Simonsick E
AU  - Hochberg MC
Y1  - 1998/10//
N1  - Accession Number: 107147602. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Instrumentation: Visual Analog Scaling; Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 7910653. 
KW  - Foot -- Physiopathology -- In Old Age
KW  - Chronic Pain -- Epidemiology -- In Old Age
KW  - Disability Evaluation -- In Old Age
KW  - Prospective Studies
KW  - Cross Sectional Studies
KW  - Stratified Random Sample
KW  - Neuropsychological Tests
KW  - Visual Analog Scaling
KW  - Scales
KW  - Geriatric Functional Assessment
KW  - Interviews
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Paired T-Tests
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - P-Value
KW  - Descriptive Statistics
KW  - Chi Square Test
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 657
EP  - 665
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 148
IS  - 7
PB  - Oxford University Press / USA
AB  - In a study of the relation between foot pain and disability, a cross-sectional analysis was performed using baseline data (1992-1995) from the Women's Health and Aging Study, a population-based study of 1,002 disabled women aged 65 years and older living in Baltimore, Maryland. Chronic and severe foot pain, defined as pain lasting 1 month or longer in the previous year, plus pain in the previous month rated severe (7-10 on a scale of 0 to 10), was reported by 14% of the women. Severe foot pain was more common in women who were younger (aged 65-74 years), obese, or had hand or knee osteoarthritis. Walking speed and five repeated chair stands were slower in women with foot pain. After adjustment for age, body mass index, race, education, self-rated health, smoking status, comorbidities, and number of other pain sites, severe foot pain was independently associated with increased risk for walking difficulty (adjusted odds ratio = 1.69, 95% confidence interval 1.10-2.59) and disability in activities of daily living (adjusted odds ratio = 1.91, 95% confidence interval 1.21-3.01). These findings suggest that severe foot pain may play a key role in disability in older women. Further studies are warranted to confirm these results longitudinally and to determine whether interventions to alleviate foot pain could reduce or prevent disability in older women.
SN  - 0002-9262
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Gateway Building, Suite 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892
U2  - PMID: 9778172.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Pack, S. D.
AU  - Pak, E.
AU  - Tanigami, A.
AU  - Ledbetter, D. H.
AU  - Fukuda, M. N.
T1  - Assignment<FOOTREF>[sup 1] </FOOTREF> of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/10//
VL  - 83
IS  - 1/2
M3  - Article
SP  - 76
EP  - 77
SN  - 03010171
AB  - This article studies the assignment of the bystin gene BYSL to human chromosome band 6p21 .1 by in situ hybridization. Bystin is a cytoplasmic protein that binds directly to trophinin and tastin which mediate homophilic adhesion between trophoblast and endometrial epithelial cells. Bystin which contains many phosphorylation sites for protein kinases may transmit cell adhesion signals leading to cell proliferation. In Drosophila, a bystin-like gene locates next to the ribosome 56 gene which regulates cell proliferation.
KW  - CHROMOSOME banding
KW  - GENE mapping
KW  - HUMAN chromosomes
KW  - IN situ hybridization
KW  - PROTEIN kinases
KW  - CELL proliferation
N1  - Accession Number: 12184330; Pack, S. D. 1 Pak, E. 1 Tanigami, A. 2 Ledbetter, D. H. 3 Fukuda, M. N. 4; Email Address: michiko@ljcrf.edu; Affiliation:  1: National Institutes of Health, National Cancer Institute, Bethesda MD (USA).  2: OtsukaGEN Institute, Kagasuno, Kawauchi-cho, Tokushima (Japan).  3: Department of Human Genetics, The University of Chicago, Chicago IL.  4: The Burnham Institute, La Jolla CA (USA).; Source Info: Oct98, Vol. 83 Issue 1/2, p76; Subject Term: CHROMOSOME banding; Subject Term: GENE mapping; Subject Term: HUMAN chromosomes; Subject Term: IN situ hybridization; Subject Term: PROTEIN kinases; Subject Term: CELL proliferation; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000015131
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Esposito, Dominic
AU  - Craigie, Robert
T1  - Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/10//10/1/98
VL  - 17
IS  - 19
M3  - Article
SP  - 5832
EP  - 5843
SN  - 02614189
AB  - HIV-1 integrase specifically recognizes and cleaves viral end DNA during the initial step of retroviral integration. The protein and DNA determinants of the specificity of viral end DNA binding have not been clearly identified. We have used mutational analysis of the viral end LTR sequence, in vitro selection of optimal viral end sequences, and specific photocrosslinking to identify regions of integrase that interact with specific bases in the LTR termini. The results highlight the involvement of the disordered loop of the integrase core domain, specifically residues Q148 and Y143, in binding to the terminal portion of the viral DNA ends. Additionally, we have identified positions upstream in the LTR termini which interact with the C-terminal domain of integrase, providing evidence for the role of that domain in stabilization of viral DNA binding. Finally, we have located a region centered 12 bases from the viral DNA terminus which appears essential for viral end DNA binding in the presence of magnesium, but not in the presence of manganese, suggesting a differential effect of divalent cations on sequence-specific binding. These results help to define important regions of contact between integrase and viral DNA, and assist in the formulation of a molecular model of this vital interaction. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - PROTEINS
KW  - BINDING sites (Biochemistry)
KW  - GENOMES
KW  - BIOCHEMISTRY
KW  - MOLECULAR biology
KW  - GENETIC engineering
KW  - hiv-1
KW  - integrase
KW  - photocrosslinking
KW  - protein­dna interactions
KW  - specific dna binding
N1  - Accession Number: 13003570; Esposito, Dominic 1 Craigie, Robert 1; Email Address: bobc@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, 5 Center Drive MSC0560, Bethesda, MD 20892, USA; Source Info: 10/1/98, Vol. 17 Issue 19, p5832; Subject Term: DNA; Subject Term: PROTEINS; Subject Term: BINDING sites (Biochemistry); Subject Term: GENOMES; Subject Term: BIOCHEMISTRY; Subject Term: MOLECULAR biology; Subject Term: GENETIC engineering; Author-Supplied Keyword: hiv-1; Author-Supplied Keyword: integrase; Author-Supplied Keyword: photocrosslinking; Author-Supplied Keyword: protein­dna interactions; Author-Supplied Keyword: specific dna binding; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/17.19.5832
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Vrasti, Radu
AU  - Grant, Bridget F.
AU  - Chatterji, Somnath
AU  - Üstün, Bedirhan T.
AU  - Mager, Doug
AU  - Olteanu, Ioan
AU  - Badoi, Marina
T1  - Reliability of the Romanian Version of the Alcohol Module of the WHO Alcohol Use Disorder and Associated Disabilities: Interview Schedule – Alcohol/Drug-Revised.
JO  - European Addiction Research
JF  - European Addiction Research
Y1  - 1998/10//
VL  - 4
IS  - 4
M3  - Article
SP  - 144
EP  - 149
SN  - 10226877
AB  - Alcohol Use Disorder and Associated Disabilities Interview Schedule – Alcohol/Drug-Revised (AUDADIS-A/D-R) is a fully structured, standardized and precoded instrument designed to evaluate alcohol and drug use disorders according to DSM-III-R, DSM-IV, and ICD-10 criteria. The AUDADIS-A/D-R has shown good to excellent reliability in both large clinical and general population samples, but prior to the conduct of the present study no data on the reliability of the Romanian version of the AUDADIS-A/D-R existed. The purpose of the present study was to examine the test-retest reliability of the alcohol module of the AUDADIS-A/D-R in a general population and clinical sample in Romania. The overall reliability of ICD-10 and DSM-IV abuse, harmful and dependence diagnoses, was found to be good to excellent, but was somewhat lower for abuse and harmful use diagnoses. The results are discussed in terms of the cultural applicability of the symptom items and within the context of the analysis of discrepant responses between the test and retest interviews. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Addiction Research is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALCOHOLISM
KW  - ALCOHOL
KW  - ALCOHOLICS
KW  - DRUG abuse
KW  - ROMANIA
KW  - Alcohol assessment
KW  - Psychiatric research
KW  - Reliability
N1  - Accession Number: 11375134; Vrasti, Radu 1 Grant, Bridget F. 2 Chatterji, Somnath 3,4 Üstün, Bedirhan T. 4 Mager, Doug 5 Olteanu, Ioan 1 Badoi, Marina 1; Affiliation:  1: Psychiatric Hospital Jebel, Research Department, Jebel, Romania  2: Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md., USA  3: National Institute on Mental Health and Neurosciences, Bangalore, India  4: Epidemiological and Managerial Support Division, Mental Health and Prevention of Substance Abuse, World Health Organization, Geneva, Switzerland  5: Washington University School of Medicine, Department of Psychiatry, St. Louis, Mo., USA; Source Info: 1998, Vol. 4 Issue 4, p144; Subject Term: ALCOHOLISM; Subject Term: ALCOHOL; Subject Term: ALCOHOLICS; Subject Term: DRUG abuse; Subject Term: ROMANIA; Author-Supplied Keyword: Alcohol assessment; Author-Supplied Keyword: Psychiatric research; Author-Supplied Keyword: Reliability; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 6p; Document Type: Article
L3  - 10.1159/000018947
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11375134&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Crippa, Flavio
AU  - Seregni, Ettore
AU  - Agresti, Roberto
AU  - Chiesa, Carlo
AU  - Pascali, Claudio
AU  - Bogni, Anna
AU  - Decise, Donatella
AU  - De Sanctis, Vinicio
AU  - Greco, Marco
AU  - Grazia Daidone, Maria
AU  - Bombardieri, Emilio
T1  - Association between [18F]fluorodeoxyglucose uptake and postoperative histopathology, hormone receptor status, thymidine labelling index and p53 in primary breast cancer: a preliminary observation.
JO  - European Journal of Nuclear Medicine
JF  - European Journal of Nuclear Medicine
Y1  - 1998/10//
VL  - 25
IS  - 10
M3  - Article
SP  - 1429
EP  - 1434
PB  - Springer Science & Business Media B.V.
SN  - 03406997
AB  - To investigate the possible role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in the prognostic evaluation of primary breast cancer, we studied 86 patients with T1–3 (TNM classification) breast tumours before surgery and compared the tumour FDG uptake, calculated as a standardized uptake value (SUV), with postoperative histopathological findings, steroid hormone receptor status of the tumour, thymidine labelling index (LI) and tissular expression of p53. SUV was significantly higher in infiltrating ductal carcinomas ( n = 68; median SUV = 5.6) than in lobular ones ( n = 18; median SUV = 3.8), and in grade 3 carcinomas ( n = 26; median SUV = 6.2) than in grade 1–2 ones ( n = 60; median SUV = 4.9). Moreover, SUV was significantly higher in carcinomas with high levels of p53 ( n = 12; median SUV = 9.5) than in those with low levels ( n = 48; median SUV = 4.25). By contrast, there was no significant correlation between SUV and the steroid hormone receptor status or LI of tumours. Our data demonstrate that FDG uptake, expressed as SUV, is associated with certain prognostic factors in breast cancer, such as histopathological grading and p53 expression, which can be assessed only by means of postoperative in vitro examinations. Hence, the information provided by FDG-PET is to some extent related to relevant information on tumour biology. The clinical value of these data will have to be confirmed by analysis of the independence of SUV from other prognostic factors by means of a multivariate analysis performed on a larger series of patients with adequate follow-up. If SUV is confirmed as an independent variable, FDG-PET could assume an important role in the determination of appropriate therapeutic strategies for primary breast cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Nuclear Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Fluorine-18 fluorodeoxyglucose
KW  - Key words: Breast cancer
KW  - PET
KW  - Positron emission tomography
KW  - Prognosis
N1  - Accession Number: 50191891; Crippa, Flavio 1 Seregni, Ettore 1 Agresti, Roberto 2 Chiesa, Carlo 1 Pascali, Claudio 1 Bogni, Anna 1 Decise, Donatella 1 De Sanctis, Vinicio 1 Greco, Marco 2 Grazia Daidone, Maria 3 Bombardieri, Emilio 1; Affiliation:  1: PET Unit, Division of Nuclear Medicine, National Cancer Institute, Milan, Italy, IT  2: Division of Surgical Oncology ”B”, National Cancer Institute, Milan, Italy, IT  3: Division of Experimental Oncology ”C”, National Cancer Institute, Milan, Italy, IT; Source Info: 1998, Vol. 25 Issue 10, p1429; Author-Supplied Keyword: Fluorine-18 fluorodeoxyglucose; Author-Supplied Keyword: Key words: Breast cancer; Author-Supplied Keyword: PET; Author-Supplied Keyword: Positron emission tomography; Author-Supplied Keyword: Prognosis; Number of Pages: 6p; Document Type: Article
L3  - 10.1007/s002590050319
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107166751
T1  - Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
AU  - Ripamonti C
AU  - Groff L
AU  - Brunelli C
AU  - Polastri D
AU  - Stavrakis A
AU  - De Conno F
AU  - Ripamonti, C
AU  - Groff, L
AU  - Brunelli, C
AU  - Polastri, D
AU  - Stavrakis, A
AU  - De Conno, F
Y1  - 1998/10//
N1  - Accession Number: 107166751. Language: English. Entry Date: 19990201. Revision Date: 20161120. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Therapy Impact Questionnaire (TIQ). Grant Information: Supported in part by grant no. AIRC 198512 from the Italian Association for Cancer Research, Milan, Italy. NLM UID: 8309333. 
KW  - Analgesics, Opioid -- Administration and Dosage
KW  - Methadone -- Administration and Dosage
KW  - Morphine -- Administration and Dosage
KW  - Cancer Pain -- Drug Therapy
KW  - Pain Measurement
KW  - Dose-Response Relationship, Drug
KW  - Neoplasms -- Complications
KW  - Pearson's Correlation Coefficient
KW  - Cross Sectional Studies
KW  - Prospective Studies
KW  - Research Instruments
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 3216
EP  - 3221
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 16
IS  - 10
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from morphine to oral methadone.Patients and Methods: A cross-sectional prospective study of 38 consecutive cancer patients who switched from morphine to oral methadone was performed. The intensity of pain before, during, and after the switching period was assessed through a four-point verbal Likert scale. The relationship between previous morphine dose and the final equianalgesic methadone dose, dose ratio between morphine and methadone, and the number of days required to achieve equianalgesia have been examined by means of Pearson's correlation coefficient, scatter plots, and Cuzick's test for trend respectively.Results: Before the switch, the median oral equivalent daily dose of morphine was 145 mg/d; after the switch, the median equianalgesic oral methadone dose was 21 mg/d. A median time of 3 days (range, 1 to 7 days) was necessary to achieve the equianalgesia with oral methadone; the lower the preswitching morphine dose, the fewer days necessary to achieve equianalgesia with oral methadone (P < .001). Dose ratios ranged from 2.5:1 to 14.3:1 (median, 7.75:1), which indicated that, in most cases, the dose ratio was much higher than that suggested by the published equianalgesic tables. A strong linear positive relationship between morphine and methadone equianalgesic doses was obtained (Pearson's correlation coefficient, 0.91). The dose ratio increased with the increase of the previous morphine dose with a much higher increase at low morphine doses.Conclusion: The results of our study confirm that methadone is a potent opioid, more potent than believed. Caution is recommended when switching from any opioid to methadone, especially in patients who are tolerant to high doses of opioids.
SN  - 0732-183X
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Via Venezian, 1, 20133 Milano, Italy; e-mail: tdpint@tin.it
U2  - PMID: 9779694.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Nanney, Lillian B.
AU  - Skeel, Alison
AU  - Luan, Jing
AU  - Polis, Sharon
AU  - Richmond, Ann
AU  - Wang, Ming‐hai
AU  - Leonard, Edward J.
T1  - Proteolytic Cleavage and Activation of pro‐Macrophage‐Stimulating Protein and Upregulation of its Receptor in Tissue Injury.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/10//
VL  - 111
IS  - 4
M3  - Article
SP  - 573
EP  - 581
SN  - 0022202X
AB  - Macrophage stimulating protein (MSP) exists in blood as inactive pro‐MSP. Cleavage yields active MSP, the ligand for a membrane receptor (RON) that is expressed on keratinocytes as well as macrophages. Because both cells have roles in tissue injury, we looked for active MSP and expressed RON in wounds. Concentration of pro‐MSP + MSP in wound exudates was in the range for optimal activity. Western blot showed that MSP comprised about half the total, in contrast to less than 10% of the total in blood plasma. The presence of MSP was attributed to an exudate pro‐MSP convertase that had an inhibitor profile consistent with a trypsin‐like serine protease. Exudate evoked morphologic changes in macrophages in vitro like that of MSP. Removal of this activity by an anti‐MSP column shows that exudate stimulation of macrophages is due to MSP. RON was infrequently detected in normal skin. RON protein was markedly upregulated in burn wound epidermis and accessory structures, in proliferating cells or differentiated cells, or both. RON was also detected on macrophages and capillaries. Tissue injury leads to cleavage of pro‐MSP to MSP, which has potential to act on keratinocytes, macrophages, and capillaries, all components of the wound healing response. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEMBRANE proteins
KW  - SKIN -- Wounds & injuries
KW  - SECRETION
KW  - enzyme activation
KW  - keratinocytes
KW  - receptor tyrosine kinase
KW  - wound. J Invest Dermatol 111:573–581 1998
N1  - Accession Number: 5549271; Nanney, Lillian B. 1,2,3,4 Skeel, Alison 1 Luan, Jing 1,3 Polis, Sharon 1,2,5 Richmond, Ann 1,3,4 Wang, Ming‐hai 1,6 Leonard, Edward J. 1; Affiliation:  1: Departments of  2: Plastic Surgery,  3: Cell Biology,  4: Department of Veterans’ Affairs, Nashville, Tennessee, U.S.A.;  5: Medicine (Dermatology), Vanderbilt School of Medicine, Nashville, Tennessee, U.S.A.;  6: Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, U.S.A.; Source Info: Oct98, Vol. 111 Issue 4, p573; Subject Term: MEMBRANE proteins; Subject Term: SKIN -- Wounds & injuries; Subject Term: SECRETION; Author-Supplied Keyword: enzyme activation; Author-Supplied Keyword: keratinocytes; Author-Supplied Keyword: receptor tyrosine kinase; Author-Supplied Keyword: wound. J Invest Dermatol 111:573–581 1998; Number of Pages: 9p; Illustrations: 16 Color Photographs, 8 Black and White Photographs, 4 Charts, 1 Graph; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00332.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hengge, Ulrich R.
AU  - Pfützner, Wolfgang
AU  - Williams, Melissa
AU  - Goos, Manfred
AU  - Vogel, Jonathan C.
T1  - Efficient Expression of Naked Plasmid DNA in Mucosal Epithelium: Prospective for the Treatment of Skin Lesions.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/10//
VL  - 111
IS  - 4
M3  - Article
SP  - 605
EP  - 608
SN  - 0022202X
AB  - Mucocutaneous gene therapy offers exciting new treatment modalities for skin lesions. Transient expression of naked plasmid DNA could be used as a local treatment of various skin lesions where the corresponding gene product (protein) has therapeutic or immunization potential. We analyzed the time course, magnitude, and histologic expression of the indicator plasmid DNA (pCMV:β‐Gal) in mucosal epithelium and papilloma lesions. Upon direct injection of naked plasmid DNA (20 μg) into oral mucosa, expression occurred at high local concentrations, up to 35‐fold higher than in comparable injections into the epidermis. Due to the accelerated turnover of mucosal epithelium β‐galactosidase positive epithelial cells were detected in the basal and suprabasal layers as early as 3 h after injection, whereas only the most superficial mucosal layers demonstrated β‐galactosidase staining at 24 h post‐injection. These biologic characteristics need to be taken into consideration when clinical applications of expressing naked plasmid DNA in epithelial tissues are considered. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN diseases
KW  - GENE therapy
KW  - PLASMIDS
KW  - EPITHELIUM
KW  - gene therapy
KW  - mucosa
KW  - wart.
N1  - Accession Number: 5549276; Hengge, Ulrich R. 1 Pfützner, Wolfgang 1,2 Williams, Melissa 1,3 Goos, Manfred 1 Vogel, Jonathan C. 2; Affiliation:  1: Department of Dermatology and Venerology, University of Essen, Germany;  2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, U.S.A.  3: National Center for Research Resources, Veterinary Resources Program at the National Institutes of Health (NIH), Bethesda, U.S.A.;; Source Info: Oct98, Vol. 111 Issue 4, p605; Subject Term: SKIN diseases; Subject Term: GENE therapy; Subject Term: PLASMIDS; Subject Term: EPITHELIUM; Author-Supplied Keyword: gene therapy; Author-Supplied Keyword: mucosa; Author-Supplied Keyword: wart.; Number of Pages: 7p; Illustrations: 8 Color Photographs, 1 Graph; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00353.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107192845
T1  - Glycocalicin levels in the plasma of HIV+ patients: an indicator of platelet turnover.
AU  - Williams SB
AU  - Sano M
AU  - Smith N
AU  - Horne M
AU  - Yarchoan R
AU  - Wyvill K
AU  - Zeichner S
AU  - Taylor P
AU  - Knudson T
AU  - Gralnick HR
Y1  - 1998/10//1998 Oct
N1  - Accession Number: 107192845. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0375375. 
KW  - Blood Platelets -- Metabolism
KW  - HIV Infections -- Blood
KW  - Platelet Aggregation Inhibitors -- Blood
KW  - Glycoproteins -- Metabolism
KW  - CD4 Lymphocyte Count
KW  - Immunosorbent Techniques
KW  - HIV Infections -- Complications
KW  - Platelet Aggregation -- Drug Effects
KW  - Platelet Count
KW  - Thrombocytopenia -- Blood
KW  - Thrombocytopenia -- Complications
KW  - Viral Load
KW  - Rabbits
KW  - Blood Donors
KW  - Child, Preschool
KW  - Child
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Human
SP  - 303
EP  - 307
JO  - Journal of Laboratory & Clinical Medicine
JF  - Journal of Laboratory & Clinical Medicine
JA  - J LAB CLIN MED
VL  - 132
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
AB  - Glycocalicin (GC) is the carbohydrate-rich portion of platelet membrane glycoprotein Ib(alpha) that can be cleaved from circulating platelets by proteases. The plasma GC level is an indicator of platelet turnover. Using an ELISA for GC, we assayed the plasma of 20 normal children (age 6 to 13 years), 50 HIV+ children (ages 4 to 18 years), 32 normal adults (ages 21 to 53 years), and 50 HIV+ adults (ages 24 to 66 years). The results were adjusted for individual platelet counts to give GC indexes (GCI). The normal children and the normal adults had significantly different GCI distributions (P = .002). In both normal and HIV+ individuals the GCI decreased with increasing platelet count (-.73 < r < -.34). Twenty-eight percent of the HIV+ children and 28% of the HIV+ adults had elevated GCI values. The majority of these elevated values occurred in patients with platelet counts >100,000/microL. Neither the GCI nor the platelet count was correlated with viral load. The platelet count, however, was weakly correlated with the CD4 count in both children (r = .31) and adults (r = .30) infected with HIV. Also, the CD4 count was weakly and inversely correlated with GCI in HIV+ adults (r = -.34) and in children (r = -.24). We conclude that increased GCI and, by implication, increased platelet turnover is a relatively common feature of advanced HIV disease. Furthermore, GCI may be elevated in HIV+ patients even with a platelet count >100,000/microL, suggesting increased platelet turnover before thrombocytopenia develops.
SN  - 0022-2143
AD  - Warren G. Magnuson Clinical Center and the HIV and Aids Malignancy Branch, National Cancer Institute, National Institutes of Health
U2  - PMID: 9794701.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107167457
T1  - Working memory capacity and suppression.
AU  - Rosen VM
AU  - Engle RW
Y1  - 1998/10//
N1  - Accession Number: 107167457. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8606159. 
KW  - Memory
KW  - Word Lists
KW  - Data Analysis Software
KW  - Analysis of Variance
KW  - Descriptive Statistics
KW  - P-Value
KW  - Human
SP  - 418
EP  - 436
JO  - Journal of Memory & Language
JF  - Journal of Memory & Language
JA  - J MEM LANG
VL  - 39
IS  - 3
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
AB  - Two experiments examined whether a relationship exists between an individual's working memory capacity and their ability to suppress intrusive thoughts and behaviors. In both experiments, participants learned three lists in a modified paired-associates task where the interference condition followed an AB-AC-AB design and the noninterference condition an EF-DC-AB design. Experiment 1 stressed speed, and individuals who scored high on a measure of working memory capacity (high spans) produced fewer first-list intrusions during second-list learning than did low spans. Experiment 2 stressed accuracy, and high spans in the interference condition were slower than their control to retrieve first-list responses on List 3, suggesting that they had suppressed them during second-list learning. In contrast, the low spans in the interference condition were faster than their control. The findings suggested that a relationship exists between an individual's working memory capacity and their ability to suppress intrusive thoughts and behaviors. (c) 1998 Academic, Press
SN  - 0749-596X
AD  - National Institute of Mental Health
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Tanaka, Eriko
AU  - Sakamoto, Shinji
AU  - Ono, Yutaka
AU  - Fujihara, Shigeki
AU  - Kitamura, Toshinori
T1  - Hopelessness in a Community Population: Factorial Structure and Psychosocial Correlates.
JO  - Journal of Social Psychology
JF  - Journal of Social Psychology
Y1  - 1998/10//
VL  - 138
IS  - 5
M3  - Article
SP  - 581
EP  - 590
PB  - Taylor & Francis Ltd
SN  - 00224545
AB  - The factorial structure of the Beck Hopelessness Scale (BHS: A. T. Beck, A. Weissman, D. Lester, & L. Trexler, 1974) was examined in a nonclinical sample (N = 154) in Japan, and the relationships between dimensions of hopelessness and psychosocial variables were analyzed. A semistructured interview was used. as well as a questionnaire consisting of the BHS, the Eysenck Personality Questionnaire (EPQ; H. J. Eysenck & S. B. Eysenck, 1975), and the Parental Bonding Instrument (PBI; G. Parker. H. Tupling, & L. B. Brown, 1979). A factor analysis with principal components solution after oblimin rotation yielded 2 factors--Doubt About a Hopeful Future (Factor 1) and Belief About a Hopeless Future (Factor 2). Significant, positive correlations were found between Factor 2 and (a) the number of emotional symptoms of depression in a 4-day depressive episode and (b) scores on the Neuroticism subscale of the EPQ. The Factor 1 score was significantly and negatively correlated with the Extraversion subscale of the EPQ and the Paternal Care subscale of the PBI. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Social Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - FACTOR structure
KW  - BECK Hopelessness Scale
KW  - DESPAIR -- Testing
KW  - DESPAIR
KW  - JAPAN
N1  - Accession Number: 1223016; Tanaka, Eriko 1 Sakamoto, Shinji 1 Ono, Yutaka 2 Fujihara, Shigeki 3 Kitamura, Toshinori 1; Affiliation:  1: Department of Sociocultural Environmental Research, National Institute of Mental Health, Chiba, Japan  2: Department of Neuropsychiatry, Keio University School of Medicine, Tokyo  3: Yamazumi Hospital, Yamanashi, Japan; Source Info: Oct1998, Vol. 138 Issue 5, p581; Subject Term: FACTOR structure; Subject Term: BECK Hopelessness Scale; Subject Term: DESPAIR -- Testing; Subject Term: DESPAIR; Subject Term: JAPAN; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 4239
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - DeRenzo, Evan G.
T1  - Power Differentials, Context, Relationship, and Emotions: Feminist Ethics Considerations and Human Subjects Research.
JO  - Journal of Women's Health
JF  - Journal of Women's Health
Y1  - 1998/10//
VL  - 7
IS  - 8
M3  - Article
SP  - 971
PB  - Mary Ann Liebert, Inc.
SN  - 10597115
AB  - The article focuses on the ethical concerns related to women's health research. Moral discomfort related with the conduct of human subjects research has received increasing attention in the media, the political arena, and within the clinical research community itself. Whereas some consider that clinical research holds the keys to ending disease, pain, and suffering, others, focusing repeatedly on the abuses and atrocities that are part and parcel of the history of human subjects research, react with fear and hostility. Clinical research appears to be sufficiently regulated to protect subjects from a repetition of the egregious misconduct of the past. Instead, what may be central to subjects' and advocates' frustration and anger about clinical research is the insistence of the biomedical research and mainstream bioethics communities on addressing the moral tensions of human subjects research is purely theoretical, rationalist ways. Continued resistance to examination of power differentials, context, relationships, and emotions-issues that feminist ethics takes as morally central may leave subjects and the public feeling that the research and bioethics communities are dodging the important moral issues.
KW  - MEDICAL ethics
KW  - MEDICAL research
KW  - CONDUCT of life
KW  - SOCIAL psychology
KW  - OFFENSES against the person
KW  - ATROCITIES
N1  - Accession Number: 5863082; DeRenzo, Evan G. 1; Affiliation:  1: Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland.; Source Info: Oct98, Vol. 7 Issue 8, p971; Subject Term: MEDICAL ethics; Subject Term: MEDICAL research; Subject Term: CONDUCT of life; Subject Term: SOCIAL psychology; Subject Term: OFFENSES against the person; Subject Term: ATROCITIES; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107172347
T1  - Choices: biomedical ethics and women's health. Power differentials, context, relationship, and emotions: feminist ethics considerations and human subjects research.
AU  - DeRenzo EG
Y1  - 1998/10//
N1  - Accession Number: 107172347. Language: English. Entry Date: 19990301. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Clinical Trials
KW  - Ethics, Medical
KW  - Feminism
KW  - Women's Health
KW  - Emotions
KW  - Patient Selection
KW  - Study Design
KW  - Power
SP  - 971
EP  - 977
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 7
IS  - 8
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - As increasing attention is paid to the ethical concerns raised by human subject research, more needs to be focused on issues usually not discussed in the research ethics literature. No longer is it sufficient to talk only about the conflicting goals of clinical care and clinical research. We need to delve more deeply into how human subjects studies are performed and examine the feminist ethics issues of power differentials, context, relationships, and emotions. The source of much of our moral discomfort with clinical trials frequently is in these components of the clinical research settings that are discussed less often.
SN  - 1059-7115
AD  - Senior Staff Fellow, Department of Clinical Bioethics, Building 10, Room 1C118, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 9812292.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107172347&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Post
AU  - Denicoff
AU  - Frye
AU  - Dunn
AU  - Leverich
AU  - Osuch
AU  - Speer
T1  - A History of the Use of Anticonvulsants as Mood Stabilizers in the Last Two Decades of the 20th Century.
JO  - Neuropsychobiology
JF  - Neuropsychobiology
Y1  - 1998/10//
VL  - 38
IS  - 3
M3  - Article
SP  - 152
EP  - 166
SN  - 0302282X
AB  - Anticonvulsants have moved into an important position as alternatives and adjuncts to lithium carbonate in the treatment of bipolar illness. Work with the nonhomologous model of kindled seizures helped in the choice of carbamazepine as a potential mood stabilizer and in the study of the mechanisms of action of the second generation anticonvulsants carbamazepine and valproate, as well as the putative third generation psychotropic anticonvulsants lamotrigine and gabapentin. Anticonvulsant neuropeptides such as TRH and nonconvulsant approaches with repeated transcranial magnetic stimulation (rTMS) also appear promising. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Neuropsychobiology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTICONVULSANTS
KW  - AFFECTIVE disorders
KW  - BIPOLAR disorder
KW  - LITHIUM
KW  - MENTAL depression
KW  - Bipolar illness
KW  - Lithium
KW  - Mania
KW  - Refractory depression
N1  - Accession Number: 11372384; Post 1 Denicoff 1 Frye 1 Dunn 1 Leverich 1 Osuch 1 Speer 1; Affiliation:  1: Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, Md., USA; Source Info: 1998, Vol. 38 Issue 3, p152; Subject Term: ANTICONVULSANTS; Subject Term: AFFECTIVE disorders; Subject Term: BIPOLAR disorder; Subject Term: LITHIUM; Subject Term: MENTAL depression; Author-Supplied Keyword: Bipolar illness; Author-Supplied Keyword: Lithium; Author-Supplied Keyword: Mania; Author-Supplied Keyword: Refractory depression; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 15p; Document Type: Article
L3  - 10.1159/000026532
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Weiss, Susan
AU  - Post, Robert
T1  - Kindling: Separate vs. Shared Mechanisms in Affective Disorders and Epilepsy.
JO  - Neuropsychobiology
JF  - Neuropsychobiology
Y1  - 1998/10//
VL  - 38
IS  - 3
M3  - Article
SP  - 167
EP  - 180
SN  - 0302282X
AB  - Kindling is discussed in relation to affective illness as a nonhomologous model, which shares the feature of increasing illness severity and evolution over time following repeated exposures to certain forms of stimulation. This progressive aspect of kindling has proven useful in the study of approaches to pharmacotherapeutics, mechanisms and characteristics of drug tolerance, and, most recently, illness suppression through physiological rather than pharmacological strategies. Each of these themes is described and the mechanisms that have been uncovered using the kindling model are discussed in relation to how similar principles might apply in affective illness or epilepsy. It is hoped that some of the lessons from the kindling model will provide useful and novel insights into aspects of treatment and mechanisms of psychiatric and neurologic illnesses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Neuropsychobiology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMYGDALOID body
KW  - TOLERATION
KW  - ANTICONVULSANTS
KW  - CONVULSIONS
KW  - PSYCHIATRY
KW  - EPILEPSY
KW  - AFFECTIVE disorders
KW  - Amygdala
KW  - Anticonvulsant
KW  - Psychiatry
KW  - Review
KW  - Seizures
KW  - Tolerance
N1  - Accession Number: 11372383; Weiss, Susan 1 Post, Robert 1; Affiliation:  1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md., USA; Source Info: 1998, Vol. 38 Issue 3, p167; Subject Term: AMYGDALOID body; Subject Term: TOLERATION; Subject Term: ANTICONVULSANTS; Subject Term: CONVULSIONS; Subject Term: PSYCHIATRY; Subject Term: EPILEPSY; Subject Term: AFFECTIVE disorders; Author-Supplied Keyword: Amygdala; Author-Supplied Keyword: Anticonvulsant; Author-Supplied Keyword: Psychiatry; Author-Supplied Keyword: Review; Author-Supplied Keyword: Seizures; Author-Supplied Keyword: Tolerance; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 14p; Document Type: Article
L3  - 10.1159/000026533
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107204431
T1  - Dietary sources of nutrients among US children, 1989-1991.
AU  - Subar AF
AU  - Krebs-Smith SM
AU  - Cook A
AU  - Kahle LL
Y1  - 1998/10//Oct98 Part 1 of 2
N1  - Accession Number: 107204431. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct98 Part 1 of 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422. 
KW  - Diet
KW  - Energy Intake
KW  - Diet -- Evaluation
KW  - Diet Records
KW  - Micronutrients
KW  - Macronutrients
KW  - Surveys
KW  - Human
SP  - 913
EP  - 923
JO  - Pediatrics
JF  - Pediatrics
JA  - PEDIATRICS
VL  - 102
IS  - 4
CY  - Chicago, Illinois
PB  - American Academy of Pediatrics
SN  - 0031-4005
AD  - National Cancer Institute, Applied Research Branch, 6130 Executive Blvd., MSC 7344, EPN 313, Bethesda, MD 20892-7344
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107204431&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Sherman, Claire D.
AU  - Portier, Christopher J.
T1  - Eyes Closed: Simple, Intuitive, Statistically Sound, and Efficient Methods for Estimating Parameters of Clonal Growth Cancer Models.
JO  - Risk Analysis: An International Journal
JF  - Risk Analysis: An International Journal
Y1  - 1998/10//
VL  - 18
IS  - 5
M3  - Letter
SP  - 529
EP  - 534
SN  - 02724332
AB  - Presents a latter to the editor about methods for estimating parameters of clonal growth cancer models.
KW  - Letters to the editor
KW  - Cancer
KW  - Cancer research
KW  - Clonal growth cancer model
KW  - Disease
KW  - Mathematical analysis
KW  - Modeling
KW  - Parameter estimation
KW  - Risk assessment
KW  - Statist
N1  - Accession Number: 8114963; Sherman, Claire D. 1; Portier, Christopher J. 2; Affiliations: 1: Department of Statistics, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku Hiroshima 732, Japan; 2: Laboratory of Computational Biology and Risk Analysis National Institute of Environmental Health Sciences P.O. Box 122330, Research Triangle Park, North Carolina 27709; Issue Info: Oct98, Vol. 18 Issue 5, p529; Subject Term: Letters to the editor; Subject Term: Cancer; Author-Supplied Keyword: Cancer research; Author-Supplied Keyword: Clonal growth cancer model; Author-Supplied Keyword: Disease; Author-Supplied Keyword: Mathematical analysis; Author-Supplied Keyword: Modeling; Author-Supplied Keyword: Parameter estimation; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Statist; Number of Pages: 6p; Document Type: Letter
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Shimizu, Mitsuru
AU  - Hochadel, James F.
AU  - Fulmer, Brandie A.
AU  - Waalkes, Michael P.
T1  - Effect of Glutathione Depletion and Metallothionein Gene Expression on Arsenic-Induced Cytotoxicity and c-myc Expression in Vitro.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/10//
VL  - 45
IS  - 2
M3  - Article
SP  - 204
EP  - 211
SN  - 10966080
AB  - Arsenic exposure is clearly linked to human cancer. In rodent cells, arsenic has been reported to induce aberrant gene expression, including activation of the proto-oncogene c-myc. Abnormal or altered expression of such oncogenes can be involved in the acquisition of a malignant phenotype. Although its mechanism of action is unclear, arsenic is known to exert at least some of its toxic effects through interaction with sulfhydryl groups, and the nonprotein sulfhydryl glutathione (GSH) appears to play an important role in detoxication of arsenic. Similarly, metallothionein (MT), a metal-binding protein with high sulfhydryl content, often functions in defense against metal-induced or oxidative cellular injury. Therefore, we examined the relationship among GSH, MT gene expression, and arsenic-induced toxicity or c-myc expression in cultured rat myoblast (L6) cells. In initial toxicity studies, arsenic was used in both the trivalent (arsenite) and pentavalent (arsenate) forms. The role of GSH was studied by pretreating cells with L-buthionine sulfoximine (BSO), which induces a marked depletion of GSH. In vitro exposure of L6 cells to BSO (1 to 25 μM) resulted in dose-dependent decreases in GSH. GSH depletion sensitized cells to both arsenite and arsenate. Zinc pretreatment, at levels which highly activated MT expression, had no effect on arsenite-induced cytotoxicity. Arsenite (1 μM) alone modestly increased c-myc expression from 1 to 4 h after treatment (maximum of 2.0-fold over control). After GSH depletion cells responded to arsenite exposure with much larger increases in c-myc transcription (3.2-fold over control). Zinc pretreatment had no reductive effect on arsenite-induced c-myc expression despite markedly activating the MT gene. Thus, it appears that the cellular levels of GSH, but not MT gene expression, play an important role in resistance to arsenic toxicity and aberrant gene activation. Moreover, depletion of GSH enhances arsenic-induced proto-on-cogene activation, which might contribute to subsequent transformation. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - arsenate
KW  - arsenic
KW  - arsenite
KW  - c-myc
KW  - glutathione
KW  - in vitro
KW  - metallothionein
KW  - rat
N1  - Accession Number: 83181340; Shimizu, Mitsuru 1; Hochadel, James F. 1; Fulmer, Brandie A. 1; Waalkes, Michael P. 1; Affiliations: 1: Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709; Issue Info: 1998, Vol. 45 Issue 2, p204; Author-Supplied Keyword: arsenate; Author-Supplied Keyword: arsenic; Author-Supplied Keyword: arsenite; Author-Supplied Keyword: c-myc; Author-Supplied Keyword: glutathione; Author-Supplied Keyword: in vitro; Author-Supplied Keyword: metallothionein; Author-Supplied Keyword: rat; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2011-03882-016
AN  - 2011-03882-016
AU  - Zhuang, P.
AU  - Dang, N.
AU  - Warzeri, A.
AU  - Gerloff, C.
AU  - Cohen, L. G.
AU  - Hallett, M.
T1  - 'Implicit and explicit learning in an auditory serial reaction time task': Erratum.
JF  - Acta Neurologica Scandinavica
JO  - Acta Neurologica Scandinavica
JA  - Acta Neurol Scand
Y1  - 1998/10//
VL  - 98
IS  - 4
SP  - 295
EP  - 295
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0001-6314
SN  - 1600-0404
AD  - Hallett, M., NINDS, NIH, Bldg 10, Rm 5N226, 10 Center Dr, MSC 1428, Bethesda, MD, US, 20892-1428
N1  - Accession Number: 2011-03882-016. Partial author list: First Author & Affiliation: Zhuang, P.; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20110620. Correction Date: 20141124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Auditory Stimulation; Implicit Learning; Motor Cortex; Serial Learning. Classification: Learning & Memory (2343). Population: Human (10). Page Count: 1. Issue Publication Date: Oct, 1998. Publication History: Accepted Date: Aug 9, 1997. Copyright Statement: Munksgaard. 1998. 
AB  - Objective: To explore the role of the motor cortex during implicit and explicit learning. Materials and methods - EEG signals were recorded from 30 channels by measuring task-related desynchronization (TRD) when 10 right-handed naive volunteers performed a variation of the serial reaction task. Stimuli, consisting of 4 pure tones of 500, 1000, 1500, and 2000 HZ, lasting 200 ms, were presented binaurally through a pair of tubephones at 60 dB with a 2-s constant interstimulus interval. A series of 10 repetitive tones represented the test sequence; the random sequence was the control. Results: All subjects developed implicit and explicit knowledge reflected by decreased response time, increased accuracy, and the ability to generate the sequence. Six of 10 subjects demonstrated implicit learning without explicit learning during the first 3 blocks. When subjects acquired full explicit learning, 10 Hz TRD at C3 reached a peak amplitude, declining thereafter. Conclusions: Properties of the sensorimotor cortex change during learning and these changes are independent of stimulus modality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - role of motor cortex in explicit & implicit learning in auditory serial reaction time task
KW  - 21–35 yr olds
KW  - 1998
KW  - Auditory Stimulation
KW  - Implicit Learning
KW  - Motor Cortex
KW  - Serial Learning
KW  - 1998
DO  - 10.1111/j.1600-0404.1998.tb07314.x
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2010-06179-008
AN  - 2010-06179-008
AU  - Tamis-Lemonda, Catherine S.
AU  - Bornstein, Marc H.
AU  - Kahana-Kalman, Ronit
AU  - Baumwell, Lisa
AU  - Cyphers, Lisa
T1  - Predicting variation in the timing of language milestones in the second year: An events history approach.
JF  - Journal of Child Language
JO  - Journal of Child Language
JA  - J Child Lang
Y1  - 1998/10//
VL  - 25
IS  - 3
SP  - 675
EP  - 700
CY  - United Kingdom
PB  - Cambridge University Press
SN  - 0305-0009
SN  - 1469-7602
AD  - Tamis-Lemonda, Catherine S., New York University, Department of Applied Psychology, 239 Greene St., 5th floor, New York, NY, US, 10003
N1  - Accession Number: 2010-06179-008. PMID: 10095330 Partial author list: First Author & Affiliation: Tamis-Lemonda, Catherine S.; New York University, New York, NY, US. Release Date: 20100405. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Tamis-Lemonda, Catherine S. Major Descriptor: Language Development; Mother Child Communication; Prediction. Minor Descriptor: Imitation (Learning). Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 26. Issue Publication Date: Oct, 1998. Copyright Statement: Cambridge University Press. 1998. 
AB  - In a longitudinal investigation of 40 child-mother dyads, we examined prediction from three indexes of children's own language: (1) vocal imitations, (2) first spontaneous words in production, and (3) receptive language starting at 0;9, and their mothers' verbal responsiveness at 0;9 and 1;1, to the developmental onset of three significant language milestones of the second year: (1) 50 words in productive language, (2) combinatorial speech, and (3) the use of language to express a memory. In these analyses, we utilized events history analysis, a statistical technique well suited to questions concerning when in development certain events begin and the extent to which predictors influence the timing of those events. The timing of children's first words in production, the timing of their achievement of 50 words in receptive language, and maternal responsiveness at 1;1 each contributed uniquely to variation in the timing of the three language milestones. When child and mother factors were considered together, the onset of the three language milestones differed by as much as 0;5 months for children in the lower and upper 10th percentiles of the predictor variables. The present findings contribute to generating and testing specific models about child and mother factors thought to explain variation in key aspects of children's second-year language development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - second year language milestones
KW  - variations
KW  - prediction
KW  - vocal imitations
KW  - first spontaneous words
KW  - receptive language
KW  - child-mother dyads
KW  - 1998
KW  - Language Development
KW  - Mother Child Communication
KW  - Prediction
KW  - Imitation (Learning)
KW  - 1998
U1  - Sponsor: Sponsor name not included, US. Grant: HD20559; HD20807; HD48915. Other Details: Research grants. Recipients: Tamis-Lemonda, Catherine S.
U1  - Sponsor: New York University, US. Other Details: Research Challenge Fund Grants. Recipients: No recipient indicated
U1  - Sponsor: Sponsor name not included, US. Grant: HD20559; HD20807. Other Details: Research grants. Recipients: Bornstein, Marc H.
U1  - Sponsor: National Institute of Child Health and Human Development, US. Grant: HD00521. Other Details: Research Career Development Award. Recipients: No recipient indicated
DO  - 10.1017/S0305000998003572
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UR  - CST@xp.psych.NYU.EDU
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41724-006
AN  - 2015-41724-006
AU  - Bowie, Derek
AU  - Lange, G. David
AU  - Mayer, Mark L.
T1  - Activity-dependent modulation of glutamate receptors by polyamines.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/10//
VL  - 18
IS  - 20
SP  - 8175
EP  - 8185
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mayer, Mark L., Building 49, Room 5A78, 49 Convent Drive, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-41724-006. PMID: 9763464 Partial author list: First Author & Affiliation: Bowie, Derek; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Glutamate Receptors; Ion Channel; AMPA. Minor Descriptor: Channel Blockers; Synaptic Plasticity. Classification: Electrophysiology (2530). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Oct, 1998. Publication History: Accepted Date: Aug 3, 1998; Revised Date: Jul 21, 1998; First Submitted Date: Jun 5, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - The mechanisms by which polyamines block AMPA and kainate receptors are not well understood, but it has been generally assumed that they act as open-channel blockers. Consistent with this, voltage-jump relaxation analysis of GluR6 equilibrium responses to domoate could be well fit, assuming that spermine, spermidine, and philanthotoxin are weakly permeable open-channel blockers. Analysis of rate constants for binding and dissociation of polyamines indicated that the voltage dependence of block arose primarily from changes in koff rather than kon. Experiments with changes in Na concentration further indicate that the voltage dependence of polyamine block was governed by ion flux via open channels. However, responses to 1 msec applications of L-Glu revealed slow voltage-dependent rise-times, suggesting that polyamines additionally bind to closed states. A kinetic model, which included closed-channel block, reproduced these observations but required that polyamines accelerate channel closure either through an allosteric mechanism or by emptying the pore of permeant ions. Simulations with this model reveal that polyamine block confers novel activity-dependent regulation on calcium-permeable AMPA and kainate receptor responses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - polyamines
KW  - glutamate receptors
KW  - plasticity
KW  - channel block
KW  - kinetic analysis
KW  - AMPA
KW  - kainate
KW  - ion channel block
KW  - ionic mechanism
KW  - 1998
KW  - Glutamate Receptors
KW  - Ion Channel
KW  - AMPA
KW  - Channel Blockers
KW  - Synaptic Plasticity
KW  - 1998
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Lindmark, G.
AU  - Berendes, H.
AU  - Meirik, O.
T1  - Antenatal care in developed countries.
JO  - Paediatric & Perinatal Epidemiology
JF  - Paediatric & Perinatal Epidemiology
Y1  - 1998/10/02/Oct98 Supplement 2
VL  - 12
M3  - Article
SP  - 4
EP  - 6
PB  - Wiley-Blackwell
SN  - 02695022
AB  - Argues for an evaluation of antenatal care programs of the developed countries.  Difficulties in conducting scientific trials to evaluate the programs; Results of some trials on antenatal care from the U.S. and Europe; Reasons for preferring private care to public clinics by women in developed countries; Desirable features of programs of antenatal care.
KW  - PRENATAL care
KW  - DEVELOPED countries
N1  - Accession Number: 9796382; Lindmark, G. 1 Berendes, H. 2 Meirik, O. 3; Affiliation:  1: Department of Women's and Children's Health, Section of International Maternal and Reproductive Health, University of Uppsala, Sweden.,  2: National Institute of Child Health and Human Development (NICHD/NIH), Bethesda MD, USA.,  3: Epidemiology Unit, Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organisation, Geneva, Switzerland.; Source Info: Oct98 Supplement 2, Vol. 12, p4; Subject Term: PRENATAL care; Subject Term: DEVELOPED countries; Number of Pages: 3p; Document Type: Article
L3  - 10.1046/j.1365-3016.12.s2.5.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9796382&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Villar, J.
AU  - Bakketeig, L.
AU  - Donner, A.
AU  - Al-Mazrou, Y.
AU  - Ba’aqeel, H.
AU  - Belizán, J.M.
AU  - Carroli, G.
AU  - Farnot, U.
AU  - Lumbiganon, P.
AU  - Piaggio, G.
AU  - Berendes, h.
T1  - The WHO Antenatal Care Randomised Controlled Trial: rationale and study design.
JO  - Paediatric & Perinatal Epidemiology
JF  - Paediatric & Perinatal Epidemiology
Y1  - 1998/10/02/Oct98 Supplement 2
VL  - 12
M3  - Article
SP  - 27
EP  - 58
PB  - Wiley-Blackwell
SN  - 02695022
AB  - The World Health Organisation and collaborating institutions in developing countries are conducting a multicentre randomised controlled trial to evaluate a new antenatal care (ANC) programme, consisting of tests, clinical procedures and follow-up actions scientifically demonstrated to be effective in improving maternal and newborn outcomes. These activities are distributed, for practical reasons, over four visits during the course of pregnancy and are aimed at achieving predetermined goals. The study is taking place in four countries, Argentina, Cuba, Saudi Arabia and Thailand. Recruitment of study subjects started on 1 May 1996. All 53 ANC clinical units had been enrolled by December 1996. Clinics in each country were randomly allocated (cluster randomisation) to provide either the new programme or the traditional programme currently in use. Approximately 24 000 women presenting for ANC at these clinics over an average period of 18 months will have been recruited. As women attending the control clinics receive the ‘best standard treatment’ as currently offered in these clinics, individual informed consent is requested only from women attending the intervention clinics. Authorities of the corresponding health districts and all participating clinics have provided written institutional informed consent before randomisation. The primary outcome of the trial in relation to maternal conditions is the rate of a morbidity indicator index, defined as the presence of at least one of the following conditions for which ANC is relevant: (a) pre-eclampsia or eclampsia during pregnancy or within 24 h of delivery; (b) postpartum anaemia (haemoglobin < 90 g/L); or (c) severe urinary tract infection/pyelonephritis, defined as an episode requiring antibiotic treatment and/or hospitalisation. The primary fetal outcome is the rate of low birthweight (< 2500 g). Adverse maternal and fetal outcomes are expected for ≈ 10% of the control group. Several maternal and perinatal secondary outcomes are also considered. A comprehensive cost-effective-ness analysis and women's and providers’ satisfaction evaluation are performed concurrently with the trial. Health-care programmes should be rigorously evaluated by randomised controlled trials, which are feasible in developing countries and should be conducted before introducing new treatments or health interventions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PRENATAL care
KW  - MEDICAL care surveys
N1  - Accession Number: 9796379; Villar, J. 1 Bakketeig, L. 2 Donner, A. 3 Al-Mazrou, Y. 4 Ba’aqeel, H. 5 Belizán, J.M. 6 Carroli, G. 6 Farnot, U. 7 Lumbiganon, P. 8 Piaggio, G. 1 Berendes, h. 9; Affiliation:  1: UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organisation, Geneva, Switzerland.,  2: National Institute of Public Health, Oslo, Norway.,  3: University of Western Ontario, London, Ontario, Canada.,  4: Ministry of Health, Riyadh, Saudi Arabia.,  5: National Guard King Khalid Hospital, Jeddah, Saudi Arabia.,  6: Centro Rosarino de Estudios Perinatales (CREP), Rosario, Argentina.,  7: Hospital Gineco-Obstétrico ‘America Arias’, Havana, Cuba.,  8: Khon Kaen University, Khon Kaen, Thailand, and National Institute of Child Health and Human Development, (NICHD/NIH), Bethesda, MD, USA.,  9: National Institute of Child Health and Human Development, (NICHD/NIH), Bethesda, MD, USA.; Source Info: Oct98 Supplement 2, Vol. 12, p27; Subject Term: PRENATAL care; Subject Term: MEDICAL care surveys; Number of Pages: 32p; Document Type: Article
L3  - 10.1046/j.1365-3016.1998.00006.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9796379&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Donner, A.
AU  - Piaggio, G.
AU  - Villar, J.
AU  - Pinol, A.
AU  - Al-Mazrou, Y.
AU  - Ba’aqeel, H.
AU  - Bakketeig, L.
AU  - Belizán, J.M.
AU  - Berendes, H.
AU  - Carroli, G.
AU  - Farnot, U.
AU  - Lumbiganon, P.
T1  - Methodological considerations in the design of the WHO Antenatal Care Randomised Controlled Trial.
JO  - Paediatric & Perinatal Epidemiology
JF  - Paediatric & Perinatal Epidemiology
Y1  - 1998/10/02/Oct98 Supplement 2
VL  - 12
M3  - Article
SP  - 59
EP  - 74
PB  - Wiley-Blackwell
SN  - 02695022
AB  - We discuss methodological issues arising in a recent evaluation trial of a new antenatal care programme, as sponsored by the Special Programme of Research, Development and Research Training in Human Reproduction, and WHO's Division of Reproductive Health (Technical Support). The randomisation unit for the trial is the antenatal care clinic, with 53 clinics located in four countries randomly allocated to provide either the new programme or the traditional programme currently in use. Approximately 24 000 women presenting for antenatal care over an average period of 18 months will have been recruited. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PRENATAL care
KW  - MEDICAL centers
N1  - Accession Number: 9796375; Donner, A. 1 Piaggio, G. 2 Villar, J. 2 Pinol, A. 2 Al-Mazrou, Y. 3 Ba’aqeel, H. 4 Bakketeig, L. 5 Belizán, J.M. 6 Berendes, H. 7 Carroli, G. 6 Farnot, U. 8 Lumbiganon, P. 9; Affiliation:  1: University of Western Ontario, London, Ontario, Canada.,  2: UNDP/UNFPA/WHO/WORLD BANK Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organisation, Geneva, Switzerland.,  3: Ministry of Health, Riyadh, Saudi Arabia.,  4: National Guard King Khalid Hospital, Jeddah, Saudi Arabia.,  5: National Institute of Public Health, Oslo, Norway.,  6: Centro Rosarino de Estudios Perinatales (CREP), Rosario, Argentina.,  7: National Institute of Child Health and Human Development (NICHD/NIH), Bethesda, MD, USA.,  8: Hospital Gineco-Obstétrico ‘América Arias’, Havana, Cuba.,  9: Khon Kaen University, Khon Kaen, Thailand.; Source Info: Oct98 Supplement 2, Vol. 12, p59; Subject Term: PRENATAL care; Subject Term: MEDICAL centers; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 16p; Document Type: Article
L3  - 10.1046/j.1365-3016.1998.00007.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9796375&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Tzahar, Eldad
AU  - Moyer, James D.
AU  - Waterman, Hadassa
AU  - Barbacci, Elsa G.
AU  - Bao, Jing
AU  - Levkowitz, Gil
AU  - Shelly, Maya
AU  - Strano, Sabrina
AU  - Pinkas-Kramarski, Ronit
AU  - Pierce, Jacalyn H.
AU  - Andrews, Gleen C.
AU  - Yarden, Yosef
T1  - Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/10/15/
VL  - 17
IS  - 20
M3  - Article
SP  - 5948
EP  - 5963
SN  - 02614189
AB  - Virulence of poxviruses, the causative agents of smallpox, depends on virus-encoded growth factors related to the mammalian epidermal growth factor (EGF). Here we report that the growth factors of Shope fibroma virus, Myxoma virus and vaccinia virus (SFGF, MGF and VGF) display unique patterns of specificity to ErbB receptor tyrosine kinases; whereas SFGF is a broad-specificity ligand, VGF binds primarily to ErbB-1 homodimers, and the exclusive receptor for MGF is a heterodimer comprised of ErbB-2 and ErbB-3. In spite of 10- to 1000-fold lower binding affinity to their respective receptors, the viral ligands are mitogenically equivalent or even more potent than their mammalian counterparts. This remarkable enhancement of cell growth is due to attenuation of receptor degradation and ubiquitination, which leads to sustained signal transduction. Our results imply that signal potentiation and precise targeting to specific receptor combinations contribute to cell transformation at sites of poxvirus infection, and they underscore the importance of the often ignored low-affinity ligand—receptor interactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA viruses
KW  - GROWTH factors
KW  - ONCOGENES
KW  - GENETIC transduction
KW  - PROTEIN-tyrosine kinase
KW  - POXVIRUSES
KW  - dna virus
KW  - growth factor
KW  - oncogene
KW  - signal transduction
KW  - tyrosine kinase
N1  - Accession Number: 13003620; Tzahar, Eldad 1 Moyer, James D. 2 Waterman, Hadassa 1 Barbacci, Elsa G. 2 Bao, Jing 1 Levkowitz, Gil 1 Shelly, Maya 1 Strano, Sabrina 1 Pinkas-Kramarski, Ronit 1 Pierce, Jacalyn H. 3 Andrews, Gleen C. 2 Yarden, Yosef 1; Email Address: liyarden@weizmann.weizmann.ac.il; Affiliation:  1: Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel  2: Pfizer Central Research, Groton, CT 06340  3: National Cancer Institute, Bethesda, MD 20892, USA; Source Info: 10/15/98, Vol. 17 Issue 20, p5948; Subject Term: DNA viruses; Subject Term: GROWTH factors; Subject Term: ONCOGENES; Subject Term: GENETIC transduction; Subject Term: PROTEIN-tyrosine kinase; Subject Term: POXVIRUSES; Author-Supplied Keyword: dna virus; Author-Supplied Keyword: growth factor; Author-Supplied Keyword: oncogene; Author-Supplied Keyword: signal transduction; Author-Supplied Keyword: tyrosine kinase; Number of Pages: 16p; Document Type: Article
L3  - 10.1093/emboj/17.20.5948
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003620&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zhang, Aixia
AU  - Altovia, Shoshy
AU  - Tiwari, Anita
AU  - Argaman, Liron
AU  - Hengge-Aronis, Regine
AU  - Storz, Gisela
T1  - The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/10/15/
VL  - 17
IS  - 20
M3  - Article
SP  - 6061
EP  - 6068
SN  - 02614189
AB  - The OxyS regulatory RNA integrates the adaptive response to hydrogen peroxide with other cellular stress responses and protects against DNA damage. Among the OxyS targets is the rpoS-encoded σs subunit of RNA polymerase. σs is a central regulator of genes induced by osmotic stress, starvation and entry into stationary phase. We examined the mechanism whereby OxyS represses rpoS expression and found that the OxyS RNA inhibits translation of the rpoS message. This repression is dependent on the hfq-encoded RNA-binding protein (also denoted host factor I, HF-I). Co-immunoprecipitation and gel mobility shift experiments revealed that the OxyS RNA binds Hfq, suggesting that OxyS represses rpoS translation by altering Hfq activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OXIDATIVE stress
KW  - CARRIER proteins
KW  - RNA
KW  - HYDROGEN peroxide
KW  - GENETIC translation
KW  - CELL metabolism
KW  - hfq protein
KW  - oxidative stress
KW  - oxys rna
KW  - rna-binding protein
KW  - rpos
N1  - Accession Number: 13003610; Zhang, Aixia 1 Altovia, Shoshy 2 Tiwari, Anita 1 Argaman, Liron 2 Hengge-Aronis, Regine 3 Storz, Gisela 1; Email Address: storz@helix.nih.gov; Affiliation:  1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA  2: Department of Molecular Genetics and Biotechnology, Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel  3: Department of of Biology, University of Konstanz, 78434 Konstanz, Germany; Source Info: 10/15/98, Vol. 17 Issue 20, p6061; Subject Term: OXIDATIVE stress; Subject Term: CARRIER proteins; Subject Term: RNA; Subject Term: HYDROGEN peroxide; Subject Term: GENETIC translation; Subject Term: CELL metabolism; Author-Supplied Keyword: hfq protein; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: oxys rna; Author-Supplied Keyword: rna-binding protein; Author-Supplied Keyword: rpos; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1093/emboj/17.20.6061
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003610&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107299279
T1  - Risk factors for infant homicide in the United States.
AU  - Overpeck MD
AU  - Brenner RA
AU  - Trumble AC
AU  - Trifiletti LB
AU  - Berendes HW
Y1  - 1998/10/22/
N1  - Accession Number: 107299279. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Infanticide
KW  - United States
KW  - Risk Factors
KW  - Infant, Newborn
KW  - Infant
KW  - Bivariate Statistics
KW  - Relative Risk
KW  - Multivariate Analysis
KW  - Maternal Age
KW  - Educational Status
KW  - Prenatal Care
KW  - Race Factors
KW  - Adolescence
KW  - Gestational Age
KW  - Parity
KW  - Incidence
KW  - Wounds and Injuries -- In Infancy and Childhood
KW  - Child Abuse
KW  - Infant Mortality
KW  - Pregnancy in Adolescence
KW  - Record Review
KW  - Sex Factors
KW  - Male
KW  - Female
KW  - Age Factors
KW  - Human
SP  - 1211
EP  - 1216
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 339
IS  - 17
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institute of Child Health and Human Development, Bldg. 6100, Rm. 7B03, 9000 Rockville Pike MCS 7510, Bethesda, MD 20892-7510
U2  - PMID: 9780342.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107299279&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107155182
T1  - Linking critical care nursing and genetics with research funding opportunities.
AU  - Sigmon HD
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 107155182. Language: English. Entry Date: 19990101. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9508191. 
KW  - Critical Care Nursing
KW  - Genetics, Medical
KW  - Research, Nursing
KW  - Research Support
KW  - Professional Development
KW  - Nurse Researchers
KW  - National Institute of Nursing Research (U.S.)
KW  - World Wide Web
KW  - Research, Nursing -- Education
SP  - 569
EP  - 573
JO  - AACN Clinical Issues: Advanced Practice in Acute & Critical Care
JF  - AACN Clinical Issues: Advanced Practice in Acute & Critical Care
JA  - AACN CLIN ISSUES ADV PRACT ACUTE CRIT CARE
VL  - 9
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The purpose of this article is threefold: to reveal how a disease that afflicts many critical care patients can be the impetus for forging into a research career; to illustrate a program of research undertaken by a nurse investigator to answer a critical care nursing question using genetic technology, and to identify exciting opportunities for research training, career development, and investigator-initiated research activities for the advanced practice critical care nurse at the National Institute of Nursing Research. The article concludes by identifying future linkages between nursing research and genetics.
SN  - 1079-0713
AD  - Division of Extramural Affairs, National Institute of Nursing Research, Building 45, Room 3AN-12, 45 Center Drive MSC 6300, Bethesda, MD 20892-6300
U2  - PMID: 9855867.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107155182&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107196969
T1  - Facilitating patient learning during medical rehabilitation: a research agenda.
AU  - Fuhrer MJ
AU  - Keith RA
Y1  - 1998/11//1998 Nov-Dec
N1  - Accession Number: 107196969. Language: English. Entry Date: 19990701. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8803677. 
KW  - Patient Education
KW  - Rehabilitation
KW  - Learning
KW  - Psychology
KW  - Research Priorities
SP  - 557
EP  - 561
JO  - American Journal of Physical Medicine & Rehabilitation
JF  - American Journal of Physical Medicine & Rehabilitation
JA  - AM J PHYS MED REHABIL
VL  - 77
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Although patient learning is widely acknowledged to be an integral part of many medical rehabilitation practices, it has been the subject of little systematic research. A workshop conducted August 18 to 19, 1997, was organized by the National Center for Medical Rehabilitation Research (National Institute of Child Health and Human Development, National Institutes of Health) and several co-sponsoring organizations to formulate recommendations concerning learning-oriented rehabilitation practices. The recommendations and their supporting rationale are summarized in the topic areas of motor learning and control, cognitive learning, recovery of functioning, generalization and transfer of training, and applications for patients with strokes, traumatic brain injury, amputations, and infants and children.
SN  - 0894-9115
AD  - National Center for Medical Rehabilitation Research, National Institutes of Health, Building 6100, Room 2A03, 6100 Executive Boulevard, Rockville, MD 20852
U2  - PMID: 9862546.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107196969&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107202592
T1  - Guest editorial. Radiologists for progress.
AU  - Staab EV
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 107202592. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 7708167. 
KW  - Technology, Radiologic -- Trends
KW  - Radiologists
KW  - Research, Medical -- Economics
SP  - 7
EP  - 8
JO  - Applied Radiology
JF  - Applied Radiology
JA  - APPL RADIOL
VL  - 27
IS  - 11
CY  - Scotch Plains, New Jersey
PB  - Anderson Publishing Ltd.
SN  - 0160-9963
AD  - National Cancer Institute, Division of Cancer Treatment, Diagnosis & Centers Radiation Research Program, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107202592&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Piscitelli, S. C.;
AU  - Forrest, A.;
AU  - Vogel, S.;
AU  - Chaitt, D.;
AU  - Kovacs, J. A.;
AU  - \ET/;
T1  - Pharmacokinetic modeling of recombinant interleukin-2 in patients with human immunodeficiency virus infection
CT  - Pharmacokinetic modeling of recombinant interleukin-2 in patients with human immunodeficiency virus infection
JO  - Clinical Pharmacology and Therapeutics (USA)
JF  - Clinical Pharmacology and Therapeutics (USA)
Y1  - 1998/11/01/
VL  - 64
IS  - Nov
SP  - 492
EP  - 498
SN  - 00099236
AD  - Clin. Ctr. Pharm. Dept., NIH, Bldg. 10, Rm. 1N257, Bethesda, MD 20892, USA Internet: spisc@nih.gov
N1  - Accession Number: 36-10696; Language: English; Chemical Name: Interleukin 2--102524-44-7; References: 26; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Pharmacology; Abstract Author: M. Therese Gyi
N2  - To characterize the time-dependent pharmacokinetics of interleukin-2 during continuous intravenous (IV) infusions and subcutaneous (SC) dosing in patients with human immunodeficiency virus (HIV) infection with use of novel indirect-effects model, 68 patients received 83 cycles of interleukin-2 by IV infusion or by SC injection for 5 days. Interleukin-2 concentrations after IV infusions peaked at 24 h and then declined by 55% to 78% during the remainder of the infusion. Soluble interleukin-2 receptors increased greater than 10-fold before gradually returning to baseline. SC dosing showed a dose-dependent increase in AUC between days 1 and 5. Both an indirect stimulatory model and a simplified empiric model provided an overall r\SU/2\BS/ of 0.99 for plot of observed vs fitted concentration. The time-dependent increase in interleukin-2 clearance was well described with the use of an indirect-effects model.
KW  - Interleukin 2--pharmacokinetics-;
KW  - HIV infections--interleukin 2--pharmacokinetic models;
KW  - Immunotherapy--interleukin 2--pharmacokinetic models;
KW  - Pharmacokinetics--interleukin 2--models;
KW  - Models--interleukin 2--pharmacokinetic-pharmacodynamic models;
KW  - Pharmacodynamics--interleukin 2--models;
KW  - Dosage--interleukin 2--pharmacokinetics;
KW  - Blood levels--interleukin 2--pharmacokinetic models;
KW  - Drug administration routes--subcutaneous--interleukin 2 pharmacokinetics;
KW  - Drug administration routes--intravenous--interleukin 2 pharmacokinetics;
KW  - Excretion--interleukin 2--IV vs SC;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=36-10696&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107161687
T1  - Differential effects of BMI on diabetes risk among black and white Americans.
AU  - Resnick HE
AU  - Valsania P
AU  - Halter JB
AU  - Lin X
Y1  - 1998/11//
N1  - Accession Number: 107161687. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by Multidisciplinary Training Grant in Aging AG-00114 from the National Institute on Aging, and by an American Association of Retired Persons/Andrus Foundation Graduate Fellowship. NLM UID: 7805975. 
KW  - Diabetes Mellitus, Type 2 -- Epidemiology
KW  - Body Mass Index
KW  - Race Factors
KW  - Risk Factors
KW  - Secondary Analysis
KW  - Blacks
KW  - Whites
KW  - Chi Square Test
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - P-Value
KW  - Descriptive Statistics
KW  - Goodness of Fit Chi Square Test
KW  - Sex Factors
KW  - Logistic Regression
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 1828
EP  - 1835
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 21
IS  - 11
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE--To determine whether the associations of BMI and fat distribution with diabetes risk are modified by race. RESEARCH DESIGN AND METHODS--Data from the National Health and Nutrition Examination Survey, Epidemiologic Follow-up Study (1971-1992), were used to investigate potential interactions of BMI and fat distribution with race. Incident diabetes was defined by self-report of physician-diagnosed diabetes, hospital and nursing home discharge records, and death certificates. RESULTS--Among the 1,531 black and 9,852 white subjects who were nondiabetic at baseline, 1,139 (10.0%) developed diabetes during 20 years of follow-up. Although the cumulative risk of diabetes increased with baseline BMI in all four race-sex groups, the sex-specific odds ratios (ORs) for black:white subjects decreased with increasing BMI. In particular, for BMI of 22 kg/m2, the OR of diabetes for black:white individuals was 1.87 and 1.76 (P< 0.01) for men and women, respectively; for BMI of 32 kg/m2, the OR decreased to 0.99 and 1.20 (NS) for men and women, respectively. Skinfold ratio was also associated with increased diabetes risk in all race-sex groups, but did not modify the association between race and diabetes. CONCLUSIONS--These findings suggest that the effect of BMI on diabetes risk is different for black and white Americans, with a larger risk for blacks than whites at low BMI and an equivalent risk for both groups at high BMI. A lower degree of visceral adiposity among blacks at higher BMI or a greater impact of visceral adiposity among blacks at low BMI may help explain the interaction of race and BMI on diabetes risk.
SN  - 0149-5992
AD  - Epidemiology, Demography, and Biometry Program (H.E.R.), National Institute on Aging, Bethesda, Maryland
U2  - PMID: 9802729.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107161687&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Qiao Li
AU  - Herrler, Michael
AU  - Landsberger, Nicoletta
AU  - Kaludov, Nikola
AU  - Ogryzko, Vasily V.
AU  - Nakatani, Yoshihiro
AU  - Wolfe, Alan P.
T1  - Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/11//11/1/98
VL  - 17
IS  - 21
M3  - Article
SP  - 6300
EP  - 6315
SN  - 02614189
AB  - We identify Xenopus NF-Y as a key regulator of acetylation responsiveness for the Xenopus hsp70 promoter within chromatin assembled in Xenopus oocyte nuclei. Y-box sequences are required for the assembly of DNase I-hypersensitive sites in the hsp70 promoter, and for transcriptional activation both by inhibitors of histone deacetylase and by the p300 acetyltransferase. The viral oncoprotein E1A interferes with both of these activation steps. We clone Xenopus NF-YA, NF-YB and NF-YC and establish that NF-Y is the predominant Y-box-binding protein in Xenopus oocyte nuclei. NF-Y interacts with p300 in vivo and is itself a target for acetylation by p300. Transcription from the hsp70 promoter in chromatin can be enhanced further by heat shock factor. We suggest two steps in chromatin modification at the Xenopus hsp70 promoter: first the binding of NF-Y to the Y-boxes to preset chromatin and second the recruitment of p300 to modulate transcriptional activity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHROMATIN
KW  - ACETYLATION
KW  - XENOPUS
KW  - HEAT shock proteins
KW  - TRANSCRIPTION factors
KW  - HISTONE deacetylase
KW  - ACETYLTRANSFERASES
KW  - CARRIER proteins
KW  - GENETIC transcription
KW  - acetylation
KW  - chromatin
KW  - hsp70 promoter
KW  - nf-y
KW  - p300
KW  - y-box
N1  - Accession Number: 13003644; Qiao Li 1 Herrler, Michael 1 Landsberger, Nicoletta 2 Kaludov, Nikola 1 Ogryzko, Vasily V. 3 Nakatani, Yoshihiro 3 Wolfe, Alan P. 1; Email Address: awlme@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Embryology , National Institute of Child  Health and Human Development, National Institutes of Health, Bethesda, MD 20892 5431, USA  2: Dipartimento di Biologia Strutturale  Funzionale, Universitá di Vrese, Via Ravasi 2, Varese, Italy  3: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Source Info: 11/1/98, Vol. 17 Issue 21, p6300; Subject Term: CHROMATIN; Subject Term: ACETYLATION; Subject Term: XENOPUS; Subject Term: HEAT shock proteins; Subject Term: TRANSCRIPTION factors; Subject Term: HISTONE deacetylase; Subject Term: ACETYLTRANSFERASES; Subject Term: CARRIER proteins; Subject Term: GENETIC transcription; Author-Supplied Keyword: acetylation; Author-Supplied Keyword: chromatin; Author-Supplied Keyword: hsp70 promoter; Author-Supplied Keyword: nf-y; Author-Supplied Keyword: p300; Author-Supplied Keyword: y-box; Number of Pages: 16p; Document Type: Article
L3  - 10.1093/emboj/17.21.6300
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003644&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107165237
T1  - ALARA study of teaching effectiveness on reducing radiation exposure...As Low As Reasonably Achievable
AU  - Feigenbaum K
AU  - Ellett ML
AU  - Miller R
AU  - Hyland L
Y1  - 1998/11//1998 Nov-Dec
N1  - Accession Number: 107165237. Language: English. Entry Date: 19990201. Revision Date: 20150819. Publication Type: Journal Article; questionnaire/scale; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Grant Information: Funded by a grant from the SGNA Foundation. NLM UID: 8915377. 
KW  - Radiation Safety -- Education
KW  - Staff Development
KW  - Gastroenterology Nursing -- Education
KW  - Surgical Technologists -- Education
KW  - Radiation Injuries -- Prevention and Control
KW  - Convenience Sample
KW  - Pretest-Posttest Design
KW  - Radiation Monitoring
KW  - Content Validity
KW  - Questionnaires
KW  - Research Instruments
KW  - Power Analysis
KW  - Data Analysis
KW  - Outcomes of Education
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 234
EP  - 238
JO  - Gastroenterology Nursing
JF  - Gastroenterology Nursing
JA  - GASTROENTEROL NURS
VL  - 21
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - The purpose of this study was to measure the effectiveness of radiation safety instruction and the impact on radiation film badge levels. A convenience sample of 144 endoscopy nurses and technicians was pretested for radiation safety knowledge, given a course in radiation safety, and then posttested immediately after the course and then 6 months later. Radiation badges were analyzed for radiation exposure at preinstruction, 1 month postinstruction, and 6 month postinstruction. Results showed that the instruction was effective. There was only a slight decrease in radiation badge readings; the decrease, however, was not statistically significant.
SN  - 1042-895X
AD  - Clinical Staff Nurse, National Institutes of Health, Bethesda, MD
U2  - PMID: 10095504.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107165237&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107160251
T1  - Use of immunotherapy for the treatment of cancer patients.
AU  - Marincola FM
Y1  - 1998/11//1998 Nov Oncology
N1  - Accession Number: 107160251. Language: English. Entry Date: 19990201. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Supplement Title: 1998 Nov Oncology. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9713898. 
KW  - Immunotherapy
KW  - Oncologic Care
KW  - Melanoma -- Therapy
KW  - Cytokines
KW  - T Lymphocytes
KW  - Antigens
KW  - Vaccines
KW  - Interleukins
KW  - Cancer Patients
SP  - 2
EP  - 9
JO  - Home Health Care Consultant
JF  - Home Health Care Consultant
JA  - HOME HEALTH CARE CONSULTANT
VL  - 5
IS  - 11
CY  - Malvern, Pennsylvania
PB  - MultiMedia HealthCare
AB  - Immunotherapy of cancer patients includes a wide variety of treatments aimed at protection of the tumor-bearing host by direct or indirect enhancement of its immune defenses. This can be achieved by nonspecific (cytokines) or specific (tumor antigen vaccines) immune stimulation or by the transfer of immune cells sensitized against cancer ex vivo. Active immunization with different anticancer vaccines has also shown promising results. The most important achievements in the understanding and characterization of the mechanisms leading to tumor rejection by the immune system will be summarized, with emphasis on their possible therapeutic implications.
SN  - 1099-5323
AD  - National Cancer Institute, Building 10, Room 21342, Bethesda, MD 20892. Email: marincola@nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107160251&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107160421
T1  - An outbreak of Bacillus species in a cancer hospital.
AU  - Thuler LCS
AU  - Velasco E
AU  - de Souza Martins CA
AU  - de Faria LMD
AU  - da Fonseca NP
AU  - de Castro Dias LM
AU  - da Silva e Castro Goncalves VM
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 107160421. Language: English. Entry Date: 19990201. Revision Date: 20150818. Publication Type: Journal Article; case study; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099. 
KW  - Disease Outbreaks
KW  - Bacillus
KW  - Immunosuppression -- Adverse Effects
KW  - Bacteremia -- Prevention and Control
KW  - Matched Case Control
KW  - Epidemiological Research
KW  - Microbial Culture and Sensitivity Tests
KW  - Data Analysis Software
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - P-Value
KW  - Multiple Logistic Regression
KW  - Chi Square Test
KW  - Fisher's Exact Test
KW  - T-Tests
KW  - Oncology Care Units
KW  - Brazil
KW  - Central Venous Catheters -- Adverse Effects
KW  - Calcium Compounds -- Adverse Effects
KW  - Cancer Patients
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Inpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 856
EP  - 858
JO  - Infection Control & Hospital Epidemiology
JF  - Infection Control & Hospital Epidemiology
JA  - INFECT CONTROL HOSP EPIDEMIOL
VL  - 19
IS  - 11
PB  - Cambridge University Press
AB  - Bacillus species were recovered from the blood cultures of 39 oncology patients over 14 weeks. A matched case-control study showed a strong association of Bacillus species bacteremia with use of calcium gluconate solution (odds ratio=25.0) and of central venous lines (odds ratio=8.8). Stopping use of the implicated calcium gluconate vials controlled the outbreak.
SN  - 0899-823X
AD  - Hospital Infection Control Committee, Hospital of Cancer, National Cancer Institute, Rio de Janeiro, Brazil
U2  - PMID: 9831944.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107160421&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lasser, Robert A.
AU  - Dukoff, Ruth
AU  - Levy, James
AU  - Levin, Robert
AU  - Lehtimäki, Tehro
AU  - Seubert, Peter
AU  - Sunderland, Trey
T1  - APOLIPOPROTEIN E ε4 ALLELE IN ASSOCIATION WITH GLOBAL COGNITIVE PERFORMANCE AND CSF MARKERS IN ALZHEIMER'S DISEASE.
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
Y1  - 1998/11//
VL  - 13
IS  - 11
M3  - Article
SP  - 767
EP  - 774
PB  - John Wiley & Sons, Inc.
SN  - 08856230
AB  - To better define the influence of apolipoprotein E (ApoE) ε4 genotype on the cognitive and biochemical features of Alzheimer's disease (AD), cross-sectional analysis of global cognitive measures and cerebrospinal fluid studies gathered on AD subjects at a tertiary care facility between 1986 and 1997 was carried out. The 112 AD patients examined included 62 women and 50 men with a mean (SD) age of 64·2 (9·2) years. Patient demographics, illness onset age and duration, education level and global cognitive measures were recorded systematically. Genetic analysis for ApoE allele type and biochemical characterization of CSF, including total tau concentration, was performed. Descriptive statistics of demographics, cognitive and CSF measures were performed by chi-square, ANOVA and Tukey's tests. Overrepresentation of the ε4 allele was found, with 45·5% of AD patients heterozygous and 20·5% homozygous for ApoE ε4. Overall, ApoE ε4 status had no effect on mean onset age of AD (F =1·56; p =0·214), but an earlier mean onset age of AD (F =4·10; p =0·02) was seen in the late-onset subjects. No differences were found with regard to ApoE ε4 status and measures of disease, duration of illness or global cognitive performance. Although CSF tau was elevated in our sample (575·4±290·3 pg/ml), ApoE ε4 status did not influence total CSF tau or neurotransmitter metabolite levels. ApoE ε4 genotype had no impact on a variety of illness severity, cognitive and CSF examinations in the largest cross-sectional analysis of AD subjects yet reported. Copyright © 1998 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APOLIPOPROTEIN E
KW  - ALZHEIMER'S disease
KW  - COGNITION
KW  - APOLIPOPROTEINS
KW  - CEREBROSPINAL fluid
KW  - Alzheimer's disease
KW  - apolipoprotein E
KW  - cognition
KW  - CSF
N1  - Accession Number: 11821096; Lasser, Robert A. 1,2 Dukoff, Ruth 1 Levy, James 1 Levin, Robert 1 Lehtimäki, Tehro 3 Seubert, Peter 4 Sunderland, Trey 1; Affiliation:  1: Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, USA  2: Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936, USA  3: Department of Clinical Chemistry, University of Tampere, Tampere, Finland  4: Athena Neurosciences, San Francisco, USA; Source Info: Nov1998, Vol. 13 Issue 11, p767; Subject Term: APOLIPOPROTEIN E; Subject Term: ALZHEIMER'S disease; Subject Term: COGNITION; Subject Term: APOLIPOPROTEINS; Subject Term: CEREBROSPINAL fluid; Author-Supplied Keyword: Alzheimer's disease; Author-Supplied Keyword: apolipoprotein E; Author-Supplied Keyword: cognition; Author-Supplied Keyword: CSF; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104799800
T1  - Apolipoprotein E epsilon 4 allele in association with global cognitive performance and CSF markers in Alzheimer's disease.
AU  - Lasser, R A
AU  - Dukoff, R
AU  - Levy, J
AU  - Levin, R
AU  - Lehtimäki, T
AU  - Seubert, P
AU  - Sunderland, T
Y1  - 1998/11//
N1  - Accession Number: 104799800. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8710629. 
KW  - Alleles
KW  - Alzheimer's Disease
KW  - Apolipoproteins
KW  - Cognition Disorders
KW  - Neuropsychological Tests
KW  - Nerve Tissue Proteins -- Cerebrospinal Fluid
KW  - Aged
KW  - Aged, 80 and Over
KW  - Alzheimer's Disease -- Cerebrospinal Fluid
KW  - Alzheimer's Disease -- Diagnosis
KW  - Cognition Disorders -- Cerebrospinal Fluid
KW  - Cognition Disorders -- Diagnosis
KW  - Female
KW  - Genes
KW  - Genetic Markers
KW  - Disease Susceptibility
KW  - Genotype
KW  - Male
KW  - Middle Age
SP  - 767
EP  - 774
JO  - International Journal of Geriatric Psychiatry
JF  - International Journal of Geriatric Psychiatry
JA  - INT J GERIATR PSYCHIATRY
VL  - 13
IS  - 11
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
AB  - To better define the influence of apolipoprotein E (ApoE) epsilon 4 genotype on the cognitive and biochemical features of Alzheimer's disease (AD), cross-sectional analysis of global cognitive measures and cerebrospinal fluid studies gathered on AD subjects at a tertiary care facility between 1986 and 1997 was carried out. The 112 AD patients examined included 62 women and 50 men with a mean (SD) age of 64.2 (9.2) years. Patient demographics; illness onset age and duration, education level and global cognitive measures were recorded systematically. Genetic analysis for ApoE allele type and biochemical characterization of CSF, including total tau concentration, was performed. Descriptive statistics of demographics, cognitive and CSF measures were performed by chi-square, ANOVA and Tukey's tests. Overrepresentation of the epsilon 4 allele was found, with 45.5% of AD patients heterozygous and 20.5% homozygous for ApoE epsilon 4. Overall, ApoE epsilon 4 status had no effect on mean onset age of AD (F = 1.56; p = 0.214), but an earlier mean onset age of AD (F = 4.10; p = 0.02) was seen in the late-onset subjects. No differences were found with regard to ApoE epsilon 4 status and measures of disease, duration of illness or global cognitive performance. Although CSF tau was elevated in our sample (575.4 +/- 290.3 pg/ml), ApoE epsilon 4 status did not influence total CSF tau or neurotransmitter metabolite levels. ApoE epsilon 4 genotype had no impact on a variety of illness severity, cognitive and CSF examinations in the largest cross-sectional analysis of AD subjects yet reported.
SN  - 0885-6230
AD  - Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, USA.
U2  - PMID: 9850873.
DO  - 10.1002/(SICI)1099-1166(1998110)13:11<767::AID-GPS866>3.0.CO;2-F
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Weyer, C.
AU  - Linkeschowa, R.
AU  - Heise, T.
AU  - Giesen, H.T.
AU  - Spraul, M.
T1  - Implications of the traditional and the new ACSM Physical Activity Recommendations on weight reduction in dietary treated obese subjects.
JO  - International Journal of Obesity & Related Metabolic Disorders
JF  - International Journal of Obesity & Related Metabolic Disorders
Y1  - 1998/11//
VL  - 22
IS  - 11
M3  - Article
SP  - 1071
PB  - Nature Publishing Group
SN  - 03070565
AB  - OBJECTIVE: To assess the acceptance of the traditional American College of Sports Medicine (ACSM) exercise recommendation (20–60 min of vigorous exercise at least three times per week) and of the new, broader Centers for Disease Control (CDC)/ACSM physical activity recommendation (30 min of moderate intensity activities on most days of the week) in an obese population and to elucidate the implications of meeting these recommendations on weight reduction during dietary treatment. DESIGN: Prospective dietary intervention study of 1000 kcal diet daily. SUBJECTS: 109 obese subjects (age: 45.6±13.1 y, body mass index (BMI): 38.1±6.0 kg/m2, (Female/Male: 81/19%) MEASUREMENTS: The time spent in moderate (3–6 MET, metabolic equivalents) and vigorous (6–10 MET) physical activities was assessed by use of the Stanford-7-Day-Physical-Activity-Recall-Questionnaire, with subsequent allocation of the subjects to one of three physical activity groups: meeting the traditional recommendation (TR), the new recommendation (NR) or neither of both (SED, sedentary subjects). Physical activity level, physical activity energy expenditure, total energy expenditure (based upon the questionnaire) and resting metabolic rate (by standard equation) were estimated at baseline. Body weight was determined at baseline and after a mean of 16.3 weeks of dietary treatment. RESULTS: The new, broader recommendation was met by twice as many of the obese subjects (34%) as was the traditional recommendation (17%). Weight reduction at follow up (−8.2±6.5 kg, 16.3±4.3 weeks, mean±s.d.) was positively correlated with the physical activity level at baseline (r=0.49, P<0.001). Meeting either the traditional or the new recommendation was associated with greater weight loss [−11.9±8.5 kg (TR) and −10.1±6.4 kg (NR), respectively, not statistically significant (NS)] as compared to being sedentary [−6.5±5.2 kg (SED), P<0.05 vs both NR and TR]. CONCLUSIONS: Not only participation in vigorous exercise, but also regular engagement in moderate intensity physical activities, as recently recommended by the CDC/ACSM, predicts greater weight reduction during dietary treatment, compared to being sedentary. The new, broader physical activity recommendation appears to be more readily accepted by obese subjects than the former ACSM recommendation on exercise training. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Obesity & Related Metabolic Disorders is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EXERCISE
KW  - SPORTS medicine
KW  - OVERWEIGHT persons
KW  - WEIGHT loss
KW  - NUTRITION counseling
KW  - UNITED States
KW  - acsm
KW  - obesity
KW  - physical activity
KW  - recommendations
KW  - weight reduction
N1  - Accession Number: 11352080; Weyer, C. 1,2 Linkeschowa, R. 1 Heise, T. 1 Giesen, H.T. 1 Spraul, M. 1; Affiliation:  1: Department of Metabolic Diseases, Nutrition (WHO Collaborating Center for Diabetes Treatment, Prevention), Heinrich-Heine-University of Düsseldorf, Germany  2: Clinical Diabetes, Nutrition Section, National Institute of Diabetes, Digestive, Kidney Diseases, National Institutes of health, 4212 N 16[supth] Street, Rm 5-41, Phoenix, AZ 85016, USA; Source Info: Nov1998, Vol. 22 Issue 11, p1071; Subject Term: EXERCISE; Subject Term: SPORTS medicine; Subject Term: OVERWEIGHT persons; Subject Term: WEIGHT loss; Subject Term: NUTRITION counseling; Subject Term: UNITED States; Author-Supplied Keyword: acsm; Author-Supplied Keyword: obesity; Author-Supplied Keyword: physical activity; Author-Supplied Keyword: recommendations; Author-Supplied Keyword: weight reduction; Number of Pages: 8p; Document Type: Article
L3  - 10.1038/sj.ijo.0800728
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11352080&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hung-Dar Chen, Robert K.
AU  - Chao-Ling Chen
AU  - Shih-Wen Huang
AU  - Hsiang-Fu Kung
AU  - Hao-Chia Chen
T1  - Characterization of Latex Allergenic Components by Capillary Zone Electrophoresis and N-Terminal Sequence Analysis.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1998/11//
VL  - 5
IS  - 6
M3  - Article
SP  - 421
EP  - 427
PB  - BioMed Central
SN  - 10217770
AB  - In a previous study, protein components purified from latex gloves that elicited allergenic reactions were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and yielded apparent molecular weights of 14, 22, 30, 34, 46, and 58 kD. These allergenic components were isolated for further characterization by capillary zone electrophoresis and N-terminal amino acid sequence analysis. These components all migrated at approximately 25 and 35 min on capillary zone electrophoresis. Diode array spectral analysis detected indistinguishable characteristics between these two protein peaks. In addition, complex formation of these components with patients’ immunoglobulin was demonstrated by capillary zone electrophoresis. Analysis of components separated by SDS-PAGE on a polyvinylidene difluoride membrane showed that the first 13 residues were identical to the sequence of hevein. Based on the criteria of charge-to-mass ratio and N-terminall amino acid sequence, our results suggest that these components of latex proteins are similar in the primary structure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LATEX
KW  - ALLERGY
KW  - CAPILLARY electrophoresis
KW  - ZONE electrophoresis
KW  - IMMUNOGLOBULINS
KW  - AMINO acid sequence
KW  - Capillary zone electrophoresis
KW  - Hevein
KW  - Latex
KW  - Sequence
N1  - Accession Number: 11372055; Hung-Dar Chen, Robert K. 1; Email Address: hchen@mail.nciferf.gov Chao-Ling Chen 2 Shih-Wen Huang 3 Hsiang-Fu Kung 4 Hao-Chia Chen 5; Affiliation:  1: Department of Large Animal Clinical Science, College of Veterinary Medicine, Gainesville, Fla., USA  2: Department of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan, ROC  3: Department of Pediatrics, College Medicine, University of Florida, Gainesville, Fla., USA  4: Laboratory of Biochemical Physiology, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Md., USA  5: Endocrinology and Reproductive Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 5 Issue 6, p421; Subject Term: LATEX; Subject Term: ALLERGY; Subject Term: CAPILLARY electrophoresis; Subject Term: ZONE electrophoresis; Subject Term: IMMUNOGLOBULINS; Subject Term: AMINO acid sequence; Author-Supplied Keyword: Capillary zone electrophoresis; Author-Supplied Keyword: Hevein; Author-Supplied Keyword: Latex; Author-Supplied Keyword: Sequence; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3  - 10.1159/000025356
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107180199
T1  - Is there a self-monitoring speech perception system?
AU  - Ludow CL
AU  - Cikoja DB
Y1  - 1998/11//1998 Nov-Dec
N1  - Accession Number: 107180199. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0260316. 
KW  - Speech Perception
KW  - Feedback
KW  - Speech
KW  - Phonology
KW  - Self Concept
SP  - 505
EP  - 510
JO  - Journal of Communication Disorders
JF  - Journal of Communication Disorders
JA  - J COMMUN DISORD
VL  - 31
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
SN  - 0021-9924
AD  - National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Voice and Speech Section, Building 10 Room 5D38, Bethesda, MD 20892. E-Mail: <ludlowc@nidcd.nih.gov>
U2  - PMID: 9836139.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Lebowitz, Barry D.
T1  - Priorities for Agenda Building: Mental Health and Primary Care.
JO  - Journal of Family Practice
JF  - Journal of Family Practice
Y1  - 1998/11//
VL  - 47
IS  - 5
M3  - Editorial
SP  - 341
EP  - 341
SN  - 00943509
AB  - The author looks at the priorities for agenda building in mental health and primary care. A regulatory model influences the direction and culture of treatment research, and in this model of investigation, there is no minimum effect size for the treatment, no minimum proportion of necessary responders, and no requirement for subject representatives. An opportunity is available to adopt a clinically relevant public health model of treatment studies. Factors like age, sex and comorbidity should no longer be the basis for exclusion.
KW  - MENTAL health
KW  - PRIMARY care (Medicine)
KW  - MEDICAL care
KW  - MEDICAL research
KW  - PUBLIC health
KW  - COMORBIDITY
N1  - Accession Number: 1311000; Lebowitz, Barry D. 1; Email Address: blebowit@mail.nih.gov; Affiliation:  1: National Institute of Mental Health, 5600 Fishers Lane, Room 10-75, Rockville, MD 20857; Source Info: Nov1998, Vol. 47 Issue 5, p341; Subject Term: MENTAL health; Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL care; Subject Term: MEDICAL research; Subject Term: PUBLIC health; Subject Term: COMORBIDITY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107157014
T1  - Clinical trials of parenteral antineoplastic agents.
AU  - Cusack G
Y1  - 1998/11//1998 Nov-Dec
N1  - Accession Number: 107157014. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts; website. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8804311. 
KW  - Antineoplastic Agents
KW  - Drug Evaluation
KW  - Clinical Trials
KW  - United States Food and Drug Administration
KW  - Protocols
KW  - Research Subject Recruitment
KW  - Nursing Role
KW  - Patient Advocacy
KW  - Documentation
KW  - Research, Nursing
KW  - Information Resources
KW  - World Wide Web
SP  - 339
EP  - 343
JO  - Journal of Intravenous Nursing
JF  - Journal of Intravenous Nursing
JA  - J INTRAVENOUS NURS
VL  - 21
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Parenteral antineoplastic regimens are being administered in a variety of healthcare settings. Clinical trials play an important role in the development and testing of these regimens. An update on the role of clinical trials in identifying new agents to combat cancer is provided. Nursing considerations, patient selection, and disease specific criteria are discussed.
SN  - 0896-5846
AD  - Division of Cancer Treatment, National Institutes of Health National Cancer Institute
U2  - PMID: 10392099.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lee, Yun-Sil
AU  - Yuspa, Stuart H.
AU  - Dlugosz, Andrzej A.
T1  - Differentiation of Cultured Human Epidermal Keratinocytes at High Cell Densities is Mediated by Endogenous Activation of the Protein Kinase C Signaling Pathway.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/11//
VL  - 111
IS  - 5
M3  - Article
SP  - 762
EP  - 766
SN  - 0022202X
AB  - Normal human epidermal keratinocytes (NHEK) grown in serum-free medium on a plastic substrate spontaneously differentiate at high cell densities in vitro. Because protein kinase C (PKC) regulates murine keratinocyte differentiation triggered by a variety of stimuli, we examined the role of this signaling pathway in density-dependent activation of NHEK differentiation. Relative to subconfluent cultures, confluent NHEK expressed markedly higher levels of multiple differentiation markers assayed by immunoblotting, including keratin 1, loricrin, filaggrin, involucrin, TGK, and SPR-1. Expression of several of these markers continued to increase for several days after cells reached confluency. The total level of several PKC isoforms was not substantially altered in NHEK harvested at different cell densities, based on immunoblotting; however, subcellular fractionation revealed that PKCα underwent a redistribution to the particulate fraction in confluent and postconfluent NHEK cultures, suggesting that this isozyme was activated under these conditions and may be involved in triggering the terminal differentiation program. Supporting this concept, inhibition of PKC function using bryostatin 1 or GF 109203X blocked the induction of keratinocyte differentiation markers at high cell densities. These data suggest that endogenous activation of PKC is responsible for cell density-mediated stimulation of NHEK differentiation, establishing a critical role for this pathway in regulating human as well as murine keratinocyte differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN kinase C
KW  - KERATINOCYTES
KW  - CELL differentiation
KW  - bryostatin
KW  - filaggrin
KW  - involucrin
KW  - keratins
KW  - loricrin
KW  - SPR-1. J Invest Dermatol 111:762–766 1998
N1  - Accession Number: 5661611; Lee, Yun-Sil 1 Yuspa, Stuart H. 1 Dlugosz, Andrzej A.; Affiliation:  1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov98, Vol. 111 Issue 5, p762; Subject Term: PROTEIN kinase C; Subject Term: KERATINOCYTES; Subject Term: CELL differentiation; Author-Supplied Keyword: bryostatin; Author-Supplied Keyword: filaggrin; Author-Supplied Keyword: involucrin; Author-Supplied Keyword: keratins; Author-Supplied Keyword: loricrin; Author-Supplied Keyword: SPR-1. J Invest Dermatol 111:762–766 1998; Number of Pages: 5p; Illustrations: 4 Diagrams; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00365.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cohen, Sandra S.
AU  - Weinstein, Mark D.
AU  - Herndier, Brian G.
AU  - Anhalt, Grant J.
AU  - Blauvelt, Andrew
T1  - No Evidence of Human Herpesvirus 8 Infection in Patients with Paraneoplastic Pemphigus, Pemphigus Vulgaris, or Pemphigus Foliaceus.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1998/11//
VL  - 111
IS  - 5
M3  - Article
SP  - 781
EP  - 783
SN  - 0022202X
AB  - Paraneoplastic pemphigus has been associated with both malignancies and multicentric Castleman’s disease; the latter is a rare angiolymphoproliferative disorder that has also been linked with human herpesvirus 8 (HHV8) infection. Other diseases definitively associated with HHV8 include Kaposi’s sarcoma and primary effusion lymphoma. In a search for additional HHV8‐associated diseases, patients with paraneoplastic pemphigus, as well as patients with pemphigus vulgaris and pemphigus foliaceus, were studied. Using an immunofluorescence assay able to specifically detect antibodies directed against lytically induced HHV8 antigens, HHV8 antibodies were not detected in sera from 24 patients with paraneoplastic pemphigus (including 10 with concomitant Castleman’s disease) nor from 19 patients with pemphigus vulgaris. Sera from patients with Kaposi’s sarcoma and from healthy U.S. blood donors were positive (25 of 26) and negative (none of 20), respectively. In addition, HHV8 DNA was not found in frozen lesional skin of five patients with pemphigus vulgaris and five patients with pemphigus foliaceus by nested polymerase chain reaction (lower limit of detection = 10 copies viral DNA per μg total cellular DNA). Finally, tissue sections of lesional skin from 10 patients with pemphigus vulgaris were negative for HHV8 by in situ hybridization, using probes able to detect both latently and lytically expressed HHV8 genes in Kaposi’s sarcoma tissue. In summary, no evidence of HHV8 infection was found in all types of pemphigus using a variety of methods. These findings do not support a general role for HHV8 in skin diseases associated with immunosuppression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HERPESVIRUS diseases
KW  - PEMPHIGUS
KW  - SERODIAGNOSIS
KW  - IN situ hybridization
KW  - POLYMERASE chain reaction
KW  - Kaposi’s sarcoma
KW  - polymerase chain reaction
KW  - serology. J Invest Dermatol 111:781–783 1998
N1  - Accession Number: 5661594; Cohen, Sandra S. 1 Weinstein, Mark D. 1,2 Herndier, Brian G. 1,2 Anhalt, Grant J. 1,3 Blauvelt, Andrew 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.;  2: Department of Pathology, University of California, San Francisco, California, U.S.A.;  3: Department of Dermatology, Johns Hopkins University, Baltimore, Maryland, U.S.A.; Source Info: Nov98, Vol. 111 Issue 5, p781; Subject Term: HERPESVIRUS diseases; Subject Term: PEMPHIGUS; Subject Term: SERODIAGNOSIS; Subject Term: IN situ hybridization; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: Kaposi’s sarcoma; Author-Supplied Keyword: polymerase chain reaction; Author-Supplied Keyword: serology. J Invest Dermatol 111:781–783 1998; Number of Pages: 3p; Illustrations: 6 Black and White Photographs, 1 Diagram; Document Type: Article
L3  - 10.1046/j.1523-1747.1998.00384.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107159376
T1  - Diseases and disorders that open a seam between the face and the self.
AU  - Slavkin HC
Y1  - 1998/11//
N1  - Accession Number: 107159376. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; directories; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Facial Expression
KW  - Facial Nerve -- Abnormalities
KW  - Facial Paralysis -- Etiology
KW  - Chromosome Disorders
KW  - Syndrome
KW  - Fetal Development
SP  - 1608
EP  - 1611
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 129
IS  - 11
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - Director, National Institute of Dental and Craniofacial Research, 31 Center Dr., MSC 2290, Building 31, Room 2C39, Bethesda, MD 20892-2290
U2  - PMID: 9818581.
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DB  - rzh
ER  - 

TY  - JOUR
AU  - Miller, A.C.
AU  - Fuciarelli, A.F.
AU  - Jackson, W.E.
AU  - Ejnik, E.J.
AU  - Emond, C.
AU  - Strocko, S.
AU  - Hogan, J.
AU  - Page, N.
AU  - Pellmar, T.
T1  - Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/11//
VL  - 13
IS  - 6
M3  - Article
SP  - 643
EP  - 648
PB  - Oxford University Press / USA
SN  - 02678357
AB  - During the 1991 Persian Gulf War several US military personnel were wounded by shrapnel fragments consisting of depleted uranium. These fragments were treated as conventional shrapnel and were not surgically removed to spare excessive tissue damage. Uranium bioassays conducted over a year after the initial uranium injury indicated a significant increase in urine uranium levels above natural background levels. The potential mutagenic effects of depleted uranium are unknown. To assess the potential mutagenic effects of long-term exposure to internalized depleted uranium, Sprague-Dawley rats were implanted with depleted uranium and their urine and serum were evaluated for mutagenic potential at various times after pellet implantation using the Ames Salmonella reversion assay. Tantalum, an inert metal widely used in prosthetic devices was used for comparison. Enhancement of mutagenic activity in Salmonella typhiurium strain TA98 and the Ames IITM mixed strains (TA7001–7006) was observed in urine samples from animals implanted with depleted uranium pellets. In contrast, urine samples from animals implanted with tantalum did not show a significant enhancement of mutagenic activity in these strains. In depleted uranium-implanted animals, urine mutagenicity increased in a dose- and time-dependent manner demonstrating a strong positive correlation with urine uranium levels (r = 0.995, P < 0.001). There was no mutagenic enhancement of any bacterial strain detected in the sera of animals implanted with either depleted uranium or tantalum pellets. The results suggest that uranium content in the urine is correlated with urine mutagenicity and that urinary mutagenicity might be used as a biomarker to detect exposure to internalized uranium. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Uranium
KW  - Urinalysis
KW  - Serum -- Analysis
KW  - Mutagenesis
KW  - Rats as laboratory animals
KW  - Artificial implants
KW  - Tantalum
N1  - Accession Number: 79238005; Miller, A.C. 1; Fuciarelli, A.F. 2; Jackson, W.E. 1; Ejnik, E.J. 1; Emond, C. 3; Strocko, S. 3; Hogan, J. 3; Page, N. 4; Pellmar, T. 3; Affiliations: 1: Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute Bethesda, MD 20889-5603; 2: Pacific Northwest Laboratories, EMP Department, Richland, WA; 3: Radiation Pathophysiology Department, Armed Forces Radiobiology Research Institute Bethesda, MD 20889-5603; 4: Molecular Pharmacology Branch, Division of Cancer Treatment, National Cancer Institute, National Institute Health Bethesda, MD 20892, USA; Issue Info: Nov1998, Vol. 13 Issue 6, p643; Thesaurus Term: Uranium; Subject Term: Urinalysis; Subject Term: Serum -- Analysis; Subject Term: Mutagenesis; Subject Term: Rats as laboratory animals; Subject Term: Artificial implants; Subject Term: Tantalum; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Erexson, Gregory L.
AU  - Cunningham, Michael L.
AU  - Tindall, Kenneth R.
T1  - Cytogenetic characterization of the transgenic Big Blue® Rat2 and Big Blue® mouse embryonic fibroblast cell lines.
JO  - Mutagenesis
JF  - Mutagenesis
Y1  - 1998/11//
VL  - 13
IS  - 6
M3  - Article
SP  - 649
EP  - 653
PB  - Oxford University Press / USA
SN  - 02678357
AB  - The transgenic Big Blue® Rat2 and Big Blue® mouse embryonic fibroblast cell lines have been used to complement the transgenic Big Blue® rat and mouse in vivo mutagenesis assays. However, limited information is available regarding the karyology of these cell lines. Therefore, we have characterized the ploidy, mitotic index, spontaneous frequencies of chromosome and chromatid aberrations and rate of micronucleus (MN) formation in both cell lines. We have also characterized the frequency of sister chromatid exchange (SCE) in transgenic Big Blue® mouse cells. Big Blue® Rat2 cells are hyperploid and have extremely high baseline frequencies of cytogenetic damage. In addition, Big Blue® Rat2 cells are BrdU-resistant, therefore, SCE frequencies cannot be assessed in these cells. We conclude that Big Blue® Rat2 cells are not useful for routine cytogenetic toxicology studies. The transgenic Big Blue® mouse cell line is polyploid and consistently yields a low mitotic index (∼1%) in untreated cells. These mouse cells also exhibited moderately high baseline frequencies of chromosome and chromatid aberrations, however, baseline frequencies of SCE and of MN were not elevated. Transgenic Big Blue® mouse embryonic fibroblasts were further studied for MN induction following treatment with Nethyl-N-nitrosourea (ENU) for 0.5 h at concentrations of 0.425,0.85 and 1.7 mM. Concentration-dependent increases in MN were observed in these cells. Thus, while an ENU-induced cytogenetic response using transgenic Big Blue® mouse cells demonstrates that this cellular model could be used to cytogenetically complement the mutagenesis assays, the low mitotic index and the high spontaneous frequency of chromosome damage confounds its use for routine genetic toxicology studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cytogenetics
KW  - Transgenic organisms
KW  - Biological assay
KW  - Rats as laboratory animals
KW  - Fibroblasts
KW  - Cell lines
KW  - Mutagenesis
N1  - Accession Number: 79238004; Erexson, Gregory L. 1; Cunningham, Michael L. 2; Tindall, Kenneth R. 1; Affiliations: 1: Molecular Mutagenesis Group, Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA; 2: Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA; Issue Info: Nov1998, Vol. 13 Issue 6, p649; Thesaurus Term: Cytogenetics; Thesaurus Term: Transgenic organisms; Thesaurus Term: Biological assay; Subject Term: Rats as laboratory animals; Subject Term: Fibroblasts; Subject Term: Cell lines; Subject Term: Mutagenesis; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104799674
T1  - The meaning of pain: cancer patients' rating and recall of pain intensity and affect.
AU  - Smith, W B
AU  - Gracely, R H
AU  - Safer, M A
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 104799674. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Affect
KW  - Attitude to Health
KW  - Memory
KW  - Neoplasms -- Physiopathology
KW  - Pain -- Physiopathology
KW  - Pain -- Psychosocial Factors
KW  - Adolescence
KW  - Adult
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Neoplasms -- Complications
KW  - Pain -- Etiology
KW  - Pain Measurement
KW  - Palliative Care -- Methods
KW  - Physical Therapy -- Adverse Effects
KW  - Clinical Trials
SP  - 123
EP  - 129
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 78
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.
U2  - PMID: 9839822.
DO  - 10.1016/S0304-3959(98)00122-5
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107203121
T1  - Clinical investigations at the NIH.
AU  - Parascandola M
Y1  - 1998/11//1998 Nov-Dec
N1  - Accession Number: 107203121. Language: English. Entry Date: 19990801. Revision Date: 20150820. Publication Type: Journal Article; pictorial. Journal Subset: Nursing; Peer Reviewed; USA. Grant Information: Supported in part by an education grant from Roerig, Division of Pfizer. NLM UID: 9810950. 
KW  - National Institutes of Health (U.S.) -- History -- United States
KW  - Clinical Trials -- History -- United States
KW  - History of Medicine -- United States
KW  - United States
KW  - Research Ethics -- History -- United States
KW  - Funding Source
SP  - 1
EP  - 21
JO  - Research Nurse
JF  - Research Nurse
JA  - RES NURSE
VL  - 4
IS  - 6
PB  - Research Nurse
SN  - 1086-5896
AD  - Department of Clinical Bioethics, National Institutes of Health
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106737337
T1  - Prostate cancer and Black men.
AU  - Brawley OW
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 106737337. Language: English. Entry Date: 20040521. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9514993. 
KW  - Blacks
KW  - Prostatic Neoplasms -- Epidemiology
KW  - Prostatic Neoplasms -- Etiology
KW  - Cancer Screening
KW  - Ethics
KW  - Male
KW  - Prostatic Neoplasms -- Drug Therapy
KW  - Prostatic Neoplasms -- Prevention and Control
KW  - Race Factors
KW  - Severity of Illness
KW  - United States
SP  - 184
EP  - 186
JO  - Seminars in Urologic Oncology
JF  - Seminars in Urologic Oncology
JA  - SEMIN UROL ONCOL
VL  - 16
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Prostate cancer is a significant cause of death among men of all races in the United States, and it does disproportionately affect Black men. This disease poses a number of questions that desperately need answers. These questions involve not just the cause and prevention of the prostate cancer, but a very real and valid question is 'does screening for and aggressive treatment of prostate cancer save lives.' Almost all questions in prostate cancer are not questions unique to blacks or whites, or any specific population. These questions can only be answered through well-designed basic and clinical research studies. This research must be supported by both physician and patient participation. Conveying truthful, accurate information in this disease in which so much is unanswered is imperative. In American medical history, black men have often been misled or misinformed oftentimes by well-meaning paternalistic individuals. Physicians and laymen teaching about this disease must themselves realize and then truthfully convey 'what is known, what is not known, and what is believed.' This will allow the layman to make educated decisions regarding screening, treatment, and participation in clinical studies.Copyright © 1998 by W.B. Saunders Company
SN  - 1081-0943
AD  - Office of Special Populations Research, National Cancer Institute, Bethesda MD 20892
U2  - PMID: 9858323.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106737339
T1  - The epidemiology of prostate cancer part I: descriptive epidemiology.
AU  - Brawley OW
AU  - Knopf K
AU  - Merrill R
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 106737339. Language: English. Entry Date: 20040521. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9514993. 
KW  - Blacks
KW  - Prostatic Neoplasms -- Epidemiology
KW  - Prostatic Neoplasms -- Risk Factors
KW  - Whites
KW  - Cancer Screening -- Methods
KW  - Clinical Trials
KW  - Epidemiological Research
KW  - Ethnic Groups
KW  - Incidence
KW  - Male
KW  - Neoplasm Staging
KW  - Prostatic Neoplasms -- Diagnosis
KW  - Prostatic Neoplasms -- Mortality
KW  - Survival Analysis
SP  - 187
EP  - 192
JO  - Seminars in Urologic Oncology
JF  - Seminars in Urologic Oncology
JA  - SEMIN UROL ONCOL
VL  - 16
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The incidence and mortality of prostate cancer is highly varied among populations and especially among blacks and whites. The incidence rates of all American populations have dramatically changed over the past 25 years. The recent increase in incidence has been attributed to prostate cancer screening. Although the incidence has increased over the past 25 years, the mortality rates although vastly different between populations have remained rather stable within populations. Prostate cancer is still a disease that primarily afflicts older men. The median age at diagnosis is 77 years for whites and 69 years for blacks. More than 80% are over the age of 65 years. Screening for prostate cancer has dramatically increased the number of men with local disease at diagnosis, but it is unclear whether screening and aggressive treatment have caused a decrease in mortality. Copyright (c) 1998 by W.B. Saunders Company
SN  - 1081-0943
AD  - Office of Special Populations Research, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 9858324.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106737341
T1  - The epidemiology of prostate cancer part II: the risk factors.
AU  - Brawley OW
AU  - Knopf K
AU  - Thompson I
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 106737341. Language: English. Entry Date: 20040521. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9514993. 
KW  - Ethnic Groups
KW  - Prostatic Neoplasms -- Epidemiology
KW  - Prostatic Neoplasms -- Risk Factors
KW  - Bacterial Infections -- Complications
KW  - Clinical Trials
KW  - Diet -- Physiology
KW  - Epidemiological Research
KW  - Geographic Factors
KW  - Hormones -- Physiology
KW  - Male
KW  - Mutation
KW  - Occupational Hazards
KW  - Prostatic Hypertrophy -- Complications
KW  - Prostatic Hypertrophy -- Physiopathology
KW  - Prostatic Neoplasms -- Familial and Genetic
KW  - Prostatic Neoplasms -- Mortality
KW  - Socioeconomic Factors
KW  - Vasectomy -- Adverse Effects
KW  - Virus Diseases -- Complications
SP  - 193
EP  - 201
JO  - Seminars in Urologic Oncology
JF  - Seminars in Urologic Oncology
JA  - SEMIN UROL ONCOL
VL  - 16
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The epidemiology of prostate cancer gives us some clues that its etiology is likely both environmental and genetic. There is extreme country to country variability in prostate cancer mortality. Countries in which dietary fat intake is greater have been shown to have higher prostate cancer mortality rates leaving some to conclude that dietary fat causes prostate cancer. Migration studies show that men moving from Japan and China adopt increased risks of prostate cancer. Secondand third-generation Japanese Americans and Chinese Americans actually have risks of prostate cancer similar to white American men. This is highly suggestive that prostate cancer has an environmental influence. The differences in black-white mortality and newer data suggesting a higher mortality among Jamaican and Brazilian men of African descent suggest there may be a genetic predisposition to prostate cancer. Some have suggested certain polymorphisms increase prostate cancer risk, whereas others are searching for genetic mutations that may increase prostate cancer risk. Africans may have an increased prevalence of these genetic risk factors. Ultimately, the cause of prostate cancer is likely to be a combination of environmental and genetic factors.Copyright (c) 1998 by W.B. Saunders Company
SN  - 1081-0943
AD  - Office of Special Populations Research, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 9858325.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106737341&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106737350
T1  - Prostate cancer treatment outcome in Blacks and Whites: a summary of the literature.
AU  - Alexander GA
AU  - Brawley OW
Y1  - 1998/11//1998 Nov
N1  - Accession Number: 106737350. Language: English. Entry Date: 20040521. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9514993. 
KW  - Blacks
KW  - Prostatic Neoplasms -- Prognosis
KW  - Prostatic Neoplasms -- Therapy
KW  - Treatment Outcomes -- Evaluation
KW  - Whites
KW  - Comparative Studies
KW  - Epidemiological Research
KW  - Incidence
KW  - Literature Review
KW  - Male
KW  - Multivariate Statistics
KW  - Neoplasm Staging
KW  - Prospective Studies
KW  - Prostatic Neoplasms -- Complications
KW  - Prostatic Neoplasms -- Risk Factors
KW  - Retrospective Design
KW  - Survival Analysis
KW  - Univariate Statistics
KW  - Human
SP  - 232
EP  - 234
JO  - Seminars in Urologic Oncology
JF  - Seminars in Urologic Oncology
JA  - SEMIN UROL ONCOL
VL  - 16
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The disparate mortality rates of prostate cancer among populations have led to the question 'is therapy as effective in blacks versus whites.' A review of the cancer literature that has assessed black-white outcomes supports the conclusion that equal treatment yields equal outcomes among equal patients. Although epidemiological studies demonstrate that blacks are disproportionately diagnosed with higher stage and higher grade disease, clinical studies show that equal treatment yields equal outcome regardless of race. Patterns-of-care studies demonstrate that there is not equal treatment in the United States among black and white patients.Copyright (c) 1998 by W B. Saunders Company
SN  - 1081-0943
AD  - Office of Special Populations Research, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 9858331.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106737350&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - George, Julia D.
AU  - Price, Catherine J.
AU  - Marr, Melissa C.
AU  - Myers, Christina B.
AU  - Schwetz, Bernard A.
AU  - Heindel, Jerrold J.
T1  - Evaluation of the Developmental Toxicity of Methacrylamide and N,N′-Methylenebisacrylamide in Swiss Mice1.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1998/11//
VL  - 46
IS  - 1
M3  - Article
SP  - 124
EP  - 133
SN  - 10966080
AB  - Timed-pregnant CD-1 outbred albino Swiss mice received either methacrylamlde (MAC; 0, 60, 120, or 180 mg/kg/day) or N,N′-methylenebisacrylamide (BAC; 0, 3, 10, or 30 mg/kg/day) po in distilled water on gestational days (GD) 6 through 17. Maternal clinical status was monitored daily. At termination (GD 17), confirmed-pregnant females (27–30 per group, MAC; 24–25 per group, BAC) were evaluated for clinical status and gestational outcome; live fetuses were examined for external, visceral, and skeletal malformations. For MAC, no treatment-related maternal mortality was observed. Maternal body weight on GD 17, maternal weight gain during treatment and gestation, and corrected maternal weight gain were reduced at the high dose. Relative maternal food and water intake was not adversely affected; neurotoxicity was not observed. Relative maternal liver weight was increased at a 120 mg/kg/day; gravid uterine weight was decreased at 180 mg/kg/day. The maternal no-observed adverse effect level (NOAEL) was 60 mg/kg/day. The NOAEL for developmental toxicity was also 60 mg/kg/day. At ≥ 120 mg/kg/day, mean fetal body weight was reduced. At 180 mg/kg/day, increased postimplantation death per litter was observed. Morphological development was not affected. The maternal NOAEL for BAC was 10 mg/kg/day. At 30 mg/kg/day, decreased maternal body weight on GD 17, maternal body weight change during treatment and gestation, corrected maternal body weight, and gravid uterine weight were observed. Relative maternal liver weight increased at 30 mg/kg/day. The developmental NOAEL was 3 mg/kg/day BAC. Mean fetal body weight was reduced at 30 mg/kg/day. At ≥ 10 mg/kg/day, an increased incidence of fetal variations (extra rib) was observed, although fetal malformation rate was unaffected. MAC and BAC were not teratogenic to Swiss mice at the doses tested. BAC was more potent than MAC in causing adverse maternal and developmental effects. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - acrylamides
KW  - developmental toxicity
KW  - mice
KW  - morphological development
KW  - teratogenicity
N1  - Accession Number: 83181315; George, Julia D. 1; Price, Catherine J. 1; Marr, Melissa C. 1; Myers, Christina B. 1; Schwetz, Bernard A. 2; Heindel, Jerrold J. 2; Affiliations: 1: Chemistry and Life Sciences, Research Triangle Institute Post Office Box 12194, Research Triangle Park, North Carolina 27709-2194; 2: † Developmental and Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; Issue Info: 1998, Vol. 46 Issue 1, p124; Author-Supplied Keyword: acrylamides; Author-Supplied Keyword: developmental toxicity; Author-Supplied Keyword: mice; Author-Supplied Keyword: morphological development; Author-Supplied Keyword: teratogenicity; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Martin, Susan E.
T1  - Real Heat: Gender and Race in the Urban Fire Service (BOOK).
JO  - Work & Occupations
JF  - Work & Occupations
Y1  - 1998/11//
VL  - 25
IS  - 4
M3  - Book Review
SP  - 539
EP  - 540
SN  - 07308884
AB  - Reviews the book "Real Heat: Gender and Race in the Urban Fire Service," by Carol Chetkovic.
KW  - Fire fighters
KW  - Nonfiction
KW  - Chetkovic, Carol
KW  - Real Heat: Gender & Race in the Urban Fire Service (Book)
N1  - Accession Number: 1233155; Martin, Susan E. 1; Affiliations: 1: National Institute on Alcohol Abuse and Alcoholism; Issue Info: Nov98, Vol. 25 Issue 4, p539; Subject Term: Fire fighters; Subject Term: Nonfiction; Reviews & Products: Real Heat: Gender & Race in the Urban Fire Service (Book); People: Chetkovic, Carol; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 821
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2008-09786-001
AN  - 2008-09786-001
AU  - Perry, Cheryl L.
AU  - Lytle, Leslie A.
AU  - Feldman, Henry
AU  - Nicklas, Theresa
AU  - Stone, Elaine
AU  - Zive, Michelle
AU  - Garceau, Anne
AU  - Kelder, Steven H.
T1  - Effects of the Child and Adolescent Trial for Cardiovascular Health (CATCH) on fruit and vegetable intake.
JF  - Journal of Nutrition Education
JO  - Journal of Nutrition Education
JA  - J Nutr Educ
Y1  - 1998/11//
VL  - 30
IS  - 6
SP  - 354
EP  - 360
CY  - Canada
PB  - BC Decker
SN  - 0022-3182
AD  - Perry, Cheryl L., Division of Epidemiology, School of Public Health, 1300 South Second Street, Suite 300, Minneapolis, MN, US, 55454
N1  - Accession Number: 2008-09786-001. Other Journal Title: Journal of Nutrition Education and Behavior. Partial author list: First Author & Affiliation: Perry, Cheryl L.; Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, US. Other Publishers: Elsevier Science. Release Date: 20090720. Correction Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Childhood Development; Food Intake; Health Behavior; Nutrition. Minor Descriptor: Cardiovascular System; Diets. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Nov, 1998. 
AB  - The purpose of this article is to report the impact of the Child and Adolescent Trial for Cardiovascular Health (CATCH) on fruit and vegetable consumption of third-through fifth-grade children.The primary messages delivered in the CATCH interventions concerned dietary fat, dietary sodium, physical activity, and smoking. However, a significant portion of the classroom curricula, parental involvement programs, and food service changes were directed at promoting a generally healthful diet, including increasing fruit and vegetable intake.Therefore, it is of interest whether the general nutrition intervention was sufficient to effect an increase in intake of fruits and vegetables. Intakes were assessed using single, food-record-assisted 24-hour recalls at baseline and follow-up.The final sample size for paired baseline and follow-up recalls was 1186.The mean unadjusted daily intake of fruits and vegetables for the entire cohort at follow-up was 4.04 servings;for fruit it was 2.13 servings, and for vegetables it was 1.91 servings.The analyses of variance revealed no differences in fruit and vegetable consumption at follow-up due to site, sex, race, sex by race, condition by sex, condition by race, or condition by race by sex. Only the baseline servings of fruits and vegetables (F = 14.89; p < .001) and site by condition (F = 3.61; p < .02) terms were significant. There were significant differences between intervention and reference conditions only at the Texas site.These findings from CATCH differ considerably from those from the 5-a-Day Power Plus study and suggest that food-based, targeted messages may be needed for changes in eating patterns. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - vegetable consumption
KW  - child trial
KW  - adolescent trial
KW  - cardiovascular health
KW  - fruit intake
KW  - vegetable intake
KW  - 1998
KW  - Adolescent Development
KW  - Childhood Development
KW  - Food Intake
KW  - Health Behavior
KW  - Nutrition
KW  - Cardiovascular System
KW  - Diets
KW  - 1998
U1  - Sponsor: National Heart, Lung, and Blood Institute, US. Grant: U01 HL 33927; U01 HL 39852; U01 HL 39870; U01 HL 33906; U01 HL 39880. Recipients: No recipient indicated
DO  - 10.1016/S0022-3182(98)70357-7
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09786-001&site=ehost-live&scope=site
UR  - perry@epivax.epi.umn.edu
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-09786-003
AN  - 2008-09786-003
AU  - Van Duyn, Mary Ann S.
AU  - Heimendinger, Jerianne
AU  - Russek-Cohen, Estelle
AU  - DiClemente, Carlo C.
AU  - Sims, Laura S.
AU  - Subar, Amy F.
AU  - Krebs-Smith, Susan M.
AU  - Pivonka, Elizabeth
AU  - Kahle, Lisa L.
T1  - Use of the transtheoretical model of change to successfully predict fruit and vegetable consumption.
JF  - Journal of Nutrition Education
JO  - Journal of Nutrition Education
JA  - J Nutr Educ
Y1  - 1998/11//
VL  - 30
IS  - 6
SP  - 371
EP  - 380
CY  - Canada
PB  - BC Decker
SN  - 0022-3182
AD  - Van Duyn, Mary Ann S., Australia New Zealand Food Authority, Macquarie House, 55 Blackall Street, Barton, ACT, Australia, 2600
N1  - Accession Number: 2008-09786-003. Other Journal Title: Journal of Nutrition Education and Behavior. Partial author list: First Author & Affiliation: Van Duyn, Mary Ann S.; Department of Nutrition and Food Science, University of Maryland at College Park, College Park, MD, US. Other Publishers: Elsevier Science. Release Date: 20090720. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diets; Eating Behavior; Health Behavior; Health Promotion; Nutrition. Minor Descriptor: Adult Attitudes; Transtheoretical Model. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 1998. 
AB  - This study examined the applicability of the transtheoretical model of change to assess readiness to increase fruit and vegetable intake in a nationally representative sample of U.S. adults. Using data from the 1991 5 A Day baseline survey of 281 1 respondents, this study developed an algorithm based in part on responses to fruit and vegetable questions for classifying people into alternative stages of change.Associations were examined between stages of change, fruit and vegetable intake, and demographic and psychosocial factors. Results indicated that individuals can be classified by stage of change vis à vis fruit and vegetable intake. Persons in the higher stages of maintenance reported intakes that met national dietary recommendations of five or more servings of fruit and vegetables daily and those in action reported intakes that approached this level. Regression analyses showed that stages of change were a significant predictor of fruit and vegetable consumption, explaining 17% of the variation in fruit and vegetable intake. Stages of change and knowing the number of fruit and vegetable servings one should eat for good health provided the most parsimonious model, explaining 25% of the variance in total fruit and vegetable intake, compared with 29% for the full model.These findings suggest that stages are a successful predictor of fruit and vegetable consumption and implies a utility for the transtheoretical theory in the design and evaluation of stage-based nutrition messages for chronic disease prevention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - vegetable intake
KW  - transtheoretical model
KW  - fruit consumption
KW  - vegetable consumption
KW  - U.S. adults
KW  - 1998
KW  - Diets
KW  - Eating Behavior
KW  - Health Behavior
KW  - Health Promotion
KW  - Nutrition
KW  - Adult Attitudes
KW  - Transtheoretical Model
KW  - 1998
DO  - 10.1016/S0022-3182(98)70359-0
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09786-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41744-022
AN  - 2015-41744-022
AU  - Wrathall, Jean R.
AU  - Li, Wen
AU  - Hudson, Lynn D.
T1  - Myelin gene expression after experimental contusive spinal cord injury.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/11//
VL  - 18
IS  - 21
SP  - 8780
EP  - 8793
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wrathall, Jean R., Department of Cell Biology, Georgetown University, 3900 Reservoir Road, Northwest, Washington, DC, US, 20007
N1  - Accession Number: 2015-41744-022. PMID: 9786985 Partial author list: First Author & Affiliation: Wrathall, Jean R.; Neurobiology Division, Department of Cell Biology, Georgetown University, Washington, DC, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wrathall, Jean R. Major Descriptor: Gene Expression; Spinal Cord; Spinal Cord Injuries; Oligodendrocytes; Progenitor Cells. Minor Descriptor: Animal Models; Rats; White Matter. Classification: Genetics (2510); Neurological Disorders & Brain Damage (3297). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Nov, 1998. Publication History: Accepted Date: Aug 14, 1998; Revised Date: Jul 20, 1998; First Submitted Date: Apr 27, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - After incomplete traumatic spinal cord injury (SCI), the spared tissue exhibits abnormal myelination that is associated with reduced or blocked axonal conductance. To examine the molecular basis of the abnormal myelination, we used a standardized rat model of incomplete SCI and compared normal uninjured tissue with that after contusion injury. We evaluated expression of mRNA for myelin proteins using in situ hybridization with oligonucleotide probes to proteolipid protein (PLP), the major protein in central myelin; myelin basic protein (MBP), a major component of central myelin and a minor component of peripheral myelin; and protein zero (P0), the major structural protein of peripheral myelin, as well as myelin transcription factor 1 (MYT1).We found reduced expression of PLP and MBP chronically after SCI in the dorsal, lateral, and ventral white matter both rostral and caudal to the injury epicenter. Detailed studies of PLP at 2 months after injury indicated that the density of expressing cells was normal but mRNA per cell was reduced. In addition, P0, normally restricted to the peripheral nervous system, was expressed both at the epicenter and in lesioned areas at least 4 mm rostral and caudal to it. Thus, after SCI, abnormal myelination of residual axons may be caused, at least in part, by changes in the transcriptional regulation of genes for myelin proteins and by altered distribution of myelin-producing cells. In addition, the expression of MYT1 mRNA and protein seemed to be upregulated after SCI in a pattern suggesting the presence of undifferentiated progenitor cells in the chronically injured cord. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - myelin
KW  - spinal cord injury
KW  - mRNA
KW  - proteolipid protein
KW  - myelin basic protein
KW  - protein zero
KW  - myelin transcription factor 1
KW  - in situ hybridization
KW  - Western analysis
KW  - immunocytochemistry
KW  - 1998
KW  - Gene Expression
KW  - Spinal Cord
KW  - Spinal Cord Injuries
KW  - Oligodendrocytes
KW  - Progenitor Cells
KW  - Animal Models
KW  - Rats
KW  - White Matter
KW  - 1998
U1  - Sponsor: National Institutes of Health, US. Grant: NS28130; NS35647. Recipients: Wrathall, Jean R.
U1  - Sponsor: National Institute for Neurological Disorders and Stroke. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41748-015
AN  - 2015-41748-015
AU  - Stevens, Beth
AU  - Tanner, Sandra
AU  - Fields, R. Douglas
T1  - Control of myelination by specific patterns of neural impulses.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/11//
VL  - 18
IS  - 22
SP  - 9303
EP  - 9311
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Fields, R. Douglas, Neurocytology and Physiology Unit, National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Developmental Neurobiology, 49 Convent Drive, Building 49, Room 5A38, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-41748-015. PMID: 9801369 Partial author list: First Author & Affiliation: Stevens, Beth; National Institute of Child Health and Human Development, Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Axons; Ganglia; Myelin Sheath; Cell Adhesion Molecules. Minor Descriptor: Dorsal Roots; Mice. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: Nov, 1998. Publication History: Accepted Date: Aug 26, 1998; Revised Date: Aug 17, 1998; First Submitted Date: Jan 28, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - A cell culture preparation equipped with stimulating electrodes was used to investigate whether action potential activity can influence myelination of mouse dorsal root ganglia axons by Schwann cells. Myelination was reduced to one-third of normal by low-frequency impulse activity (0.1 Hz), but higher-frequency stimulation (1 Hz) had no effect. The number of Schwann cells and the ultrastructure of compact myelin were not affected. The frequency of stimulation that inhibited myelination decreased expression of the cell adhesion molecule L1, and stimulation under conditions that prevented the reduction in L1 blocked the effects on myelination. This link between myelination and functional activity in the axon at specific frequencies that change axonal expression of L1 could have important consequences for the structural and functional relationship of myelinating axons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - myelination
KW  - impulse activity
KW  - L1
KW  - DRG neuron
KW  - Schwann cell
KW  - cell adhesion molecule
KW  - 1998
KW  - Axons
KW  - Ganglia
KW  - Myelin Sheath
KW  - Cell Adhesion Molecules
KW  - Dorsal Roots
KW  - Mice
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41748-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107090999
T1  - Hostility, social support, and coronary heart disease in the National Heart, Lung, and Blood Institute Family Heart Study.
AU  - Knox SS
AU  - Siegmund KD
AU  - Weidner G
AU  - Ellison RC
AU  - Adelman A
AU  - Paton C
Y1  - 1998/11/15/
N1  - Accession Number: 107090999. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported by contracts N01-HC-25104 through 25109 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. NLM UID: 0207277. 
KW  - Coronary Disease -- Psychosocial Factors
KW  - Support, Psychosocial
KW  - Anger
KW  - Coronary Disease -- Etiology
KW  - Family
KW  - Coronary Disease -- Familial and Genetic
KW  - Scales
KW  - Cross Sectional Studies
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Logistic Regression
KW  - Data Analysis Software
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 1192
EP  - 1196
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
JA  - AM J CARDIOL
VL  - 82
IS  - 10
CY  - Philadelphia, Pennsylvania
PB  - Elsevier Inc.
SN  - 0002-9149
AD  - National, Heart, Lung, and Blood Institute, II Rockledge Center, 6701 Rockledge Dr, MSC 7936, Bethesda, Maryland 20892-7636
U2  - PMID: 9832093.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107090999&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Safrany, Stephen T.
AU  - Caffrey, James J.
AU  - Xiaonian Yang
AU  - Bembenek, Michael E.
AU  - Moyer, Mary B.
AU  - Burkhart, William A.
AU  - Shears, Stephen B.
T1  - A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/11/15/
VL  - 17
IS  - 22
M3  - Article
SP  - 6599
EP  - 6607
SN  - 02614189
AB  - Diphosphoinositol pentakisphosphate (PP-InsP5 or ‘InsP7’) and bisdiphosphoinositol tetrakisphosphate ([PP]2-InsP4 or ‘InsP8’) are the most highly phosphorylated members of the inositol-based cell signaling family. We have purified a rat hepatic diphosphoinositol polyphosphate phosphohydrolase (DIPP) that cleaves a β-phosphate from the diphosphate groups in PP-InsP5 (Km=340 nM) and [PP]2-InsP4 (Km=34 nM). Inositol hexakisphophate (InsP6) was not a substrate, but it inhibited metabolism of both [PP]2-InsP4 and PP-InsP5 (IC50=0.2 and 3 μM, respectively). Microsequencing of DIPP revealed a ‘MutT’ domain, which in other contexts guards cellular integrity by dephosphorylating 8-oxo-dGTP, which causes AT to CG transversion mutations. The MutT domain also metabolizes some nucleoside phosphates that may play roles in signal transduction. The rat DIPP MutT domain is conserved in a novel recombinant human uterine DIPP. The nucleotide sequence of the human DIPP cDNA was aligned to chromosome 6; the candidate gene contains at least four exons. The dependence of DIPP's catalytic activity upon its MutT domain was confirmed by mutagenesis of a conserved glutamate residue. DIPP's low molecular size, Mg2+ dependency and catalytic preference for phosphoanhydride bonds are also features of other MutT-type proteins. Because overlapping substrate specificity is a feature of this class of proteins, our data provide new directions for future studies of higher inositol phosphates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHORYLATION
KW  - INOSITOL phosphates
KW  - PHOSPHATASES
KW  - NUCLEOTIDE sequence
KW  - DNA
KW  - PROTEINS
KW  - inositol phosphates
KW  - mutt
KW  - phosphohydrolase
N1  - Accession Number: 13003681; Safrany, Stephen T. 1; Email Address: sfrany@niehs.nih.gov Caffrey, James J. 1 Xiaonian Yang 1 Bembenek, Michael E. 1,2 Moyer, Mary B. 1,3 Burkhart, William A. 1,3 Shears, Stephen B. 1; Affiliation:  1: Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, PO Box 12233, NC 27709, USA  2: NEN Life Science Products Inc., 549 Albany Street, Boston MA 02118, USA  3: Glaxo-Wellcome Research and Development, Department of Analytical Chemistry, Research Triangle Park, NC 27709, USA; Source Info: 11/15/98, Vol. 17 Issue 22, p6599; Subject Term: PHOSPHORYLATION; Subject Term: INOSITOL phosphates; Subject Term: PHOSPHATASES; Subject Term: NUCLEOTIDE sequence; Subject Term: DNA; Subject Term: PROTEINS; Author-Supplied Keyword: inositol phosphates; Author-Supplied Keyword: mutt; Author-Supplied Keyword: phosphohydrolase; Number of Pages: 9p; Document Type: Article
L3  - 10.1093/emboj/17.22.6599
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003681&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hui Ge
AU  - Yuanzheng Si
AU  - Roeder, Robert G.
T1  - Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1998/11/15/
VL  - 17
IS  - 22
M3  - Article
SP  - 6723
EP  - 6729
SN  - 02614189
AB  - Transcriptional activation in human cell-free systems containing RNA polymerase II and general initiation factors requires the action of one or more additional coactivators. Here, we report the isolation of cDNAs encoding two novel human transcriptional coactivators (p52 and p75) that are derived from alternatively spliced products of a single gene and share a region of 325 residues, but show distinct coactivator properties. p52 and p75 both show strong interactions with the VP16 activation domain and several components of the general transcriptional machinery. p52, like the previously described PC4, is a potent broad-specificity coactivator, whereas p75 is less active for most activation domains. These results suggest that p52 is a general transcriptional coactivator that mediates functional interactions between upstream sequence-specific activators and the general transcription apparatus, possibly through a novel mechanism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RNA polymerases
KW  - EUKARYOTIC cells
KW  - TRANSCRIPTION factors
KW  - DNA
KW  - GENETIC regulation
KW  - DNA-binding proteins
KW  - coactivators
KW  - p52
KW  - p75
KW  - pc4
KW  - transcriptional activation
N1  - Accession Number: 13003670; Hui Ge 1; Email Address: geh@box-g.nih.gov Yuanzheng Si 1 Roeder, Robert G. 1,2; Affiliation:  1: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA  2: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA; Source Info: 11/15/98, Vol. 17 Issue 22, p6723; Subject Term: RNA polymerases; Subject Term: EUKARYOTIC cells; Subject Term: TRANSCRIPTION factors; Subject Term: DNA; Subject Term: GENETIC regulation; Subject Term: DNA-binding proteins; Author-Supplied Keyword: coactivators; Author-Supplied Keyword: p52; Author-Supplied Keyword: p75; Author-Supplied Keyword: pc4; Author-Supplied Keyword: transcriptional activation; Number of Pages: 7p; Document Type: Article
L3  - 10.1093/emboj/17.22.6723
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Grechez-Cassiau, Aline
AU  - Bernard, Marianne
AU  - Ladjali, Kafia
AU  - Rodriguez, Ignacio R.
AU  - Voisin, Pierre
T1  - Structural analysis of the chicken hydroxyindole-O-methyltransferase gene.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1998/11/15/Nov98 Part 2
VL  - 258
IS  - 1
M3  - Article
SP  - 44
EP  - 52
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the final step of melatonin synthesis, a neurohormone involved in photoperiodism and produced specifically in the pineal gland and in the retina. In the chicken, HIOMT gene transcription appears to be controlled by a circadian oscillator located in the pineal gland. We have characterized the chicken HIOMT gene over 17 kb, including 2.9 kb of 5′-flanking sequence. The major transcript (1.6 kb) is composed of eight exons distributed over 7.5 kb of genomic DNA. A ninth alternative exon was identified 6 kb downstream of exon 8. It was found in minor transcripts in the pineal gland and in the retina. Sequence similarity between exons 8 and 9 suggests their origin by exon duplication. Due to early stop codons, inclusion of exon 9 truncates the open reading frame by up to 33 %. A restriction fragment length polymorphism was detected for a BglII site in intron 8. Fluorescence hybridization localized the HIOMT gene on chicken chromosome 1q22. The 5′-flanking region contains GATTAA and TAATCC sequences that may be related to tissue-specific expression. An ATTTAAAT sequence at position -29 would play the role of a TATA box, as evidenced by electrophoretic mobility shift assay. Information obtained in this study open the way to further studies aimed at analyzing the circadian rhythm of transcription at promoter level. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHICKENS
KW  - MELATONIN
KW  - HYBRIDIZATION
KW  - GENETICS
KW  - chicken
KW  - HIOMT gene.
KW  - melatonin
KW  - pineal
KW  - retina
N1  - Accession Number: 5276909; Grechez-Cassiau, Aline 1 Bernard, Marianne 1 Ladjali, Kafia 2 Rodriguez, Ignacio R. 3 Voisin, Pierre 1; Affiliation:  1: Laboratory of Cellular Neurobiology, UMR CNRS 6558, UFR Sciences, Poitiers, France  2: Institute of Embryology, UPR CNRS 9064, Nogent sur Marne, France  3: Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, Bethesda, USA; Source Info: Nov98 Part 2, Vol. 258 Issue 1, p44; Subject Term: CHICKENS; Subject Term: MELATONIN; Subject Term: HYBRIDIZATION; Subject Term: GENETICS; Author-Supplied Keyword: chicken; Author-Supplied Keyword: HIOMT gene.; Author-Supplied Keyword: melatonin; Author-Supplied Keyword: pineal; Author-Supplied Keyword: retina; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 6 Diagrams, 1 Graph; Document Type: Article
L3  - 10.1046/j.1432-1327.1998.2580044.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107165289
T1  - What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.
AU  - Zhang J
AU  - Yu KF
AU  - Zhang, J
AU  - Yu, K F
Y1  - 1998/11/18/
N1  - Accession Number: 107165289. Language: English. Entry Date: 19990201. Revision Date: 20161112. Publication Type: journal article; tables/charts. Commentary: McNutt L A, Hafner J P, Xue X. Correcting the odds ratio in cohort studies of common outcomes. (JAMA) 8/11/99; 282 (6): 529-529. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Relative Risk
SP  - 1690
EP  - 1691
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 280
IS  - 19
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Logistic regression is used frequently in cohort studies and clinical trials. When the incidence of an outcome of interest is common in the study population (>10%), the adjusted odds ratio derived from the logistic regression can no longer approximate the risk ratio. The more frequent the outcome, the more the odds ratio overestimates the risk ratio when it is more than 1 or underestimates it when it is less than 1. We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk.
SN  - 0098-7484
AD  - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA
AD  - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bldg 6100, Room 7B03, Bethesda, MD 20892-7510; e-mail: Jun_Zhang@NIH.GOV
U2  - PMID: 9832001.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107174490
T1  - Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews.
AU  - Silverman DT
AU  - Swanson CA
AU  - Gridley G
AU  - Wacholder S
AU  - Greenberg RS
AU  - Brown LM
AU  - Hayes RB
AU  - Swanson GM
AU  - Schoenberg JB
AU  - Pottern LM
AU  - Schwartz AG
AU  - Fraumeni JF Jr.
AU  - Hoover RN
Y1  - 1998/11/18/
N1  - Accession Number: 107174490. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported by Public Health Service contracts N01CP51090, N01CP51089, N01CP51092, N01CN05225, N01CN31022, and C01CN05227 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. NLM UID: 7503089. 
KW  - Pancreatic Neoplasms -- Etiology
KW  - Diet
KW  - Food
KW  - Energy Intake
KW  - Pancreatic Neoplasms -- Ethnology
KW  - Body Mass Index
KW  - Blacks
KW  - Whites
KW  - Case Control Studies
KW  - Interviews
KW  - Confidence Intervals
KW  - Odds Ratio
KW  - Funding Source
KW  - Human
SP  - 1710
EP  - 1719
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 90
IS  - 22
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, Executive Plaza North, Rm 418, Bethesda, MD 20892 (e-mail: silvermd@EPNDCE.NCI.NIH.GOV)
U2  - PMID: 9827525.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kawahara, Atsuo
AU  - Kobayashi, Toshiko
AU  - Nagata, Shigekazu
T1  - Inhibition of Fas-induced apoptosis by Bcl-2.
JO  - Oncogene
JF  - Oncogene
Y1  - 1998/11/19/
VL  - 17
IS  - 20
M3  - Article
SP  - 2549
EP  - 2554
PB  - Nature Publishing Group
SN  - 09509232
AB  - Jurkat cells express Fas, and rapidly undergo apoptosis in response to Fas ligand or an agonistic anti-Fas antibody. This apoptotic pathway is mediated by a cascade of caspases. In this report, we show that Fas activation induced the processing of caspase 8 in Jurkat cells with a time frame similar to the activation of caspase 3 and the proteolysis of nuclear proteins. Jurkat cell transformants that overexpress Bcl-2 were partially but not completely resistant to the Fas-induced apoptosis. Little processing of caspase 8 was observed upon Fas activation in these transformants. Furthermore, although caspase 8 was recruited to Fas upon Fas activation in the parental Jurkat cells, the recruitment of caspase 8 to Fas was inhibited in the transformants overexpressing Bcl-2. These results suggest that Bcl-2 inhibits Fas-induced apoptosis by preventing the formation of the death-inducing signaling complex that is composed of Fas, FADD/MORT1, and caspase 8. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APOPTOSIS
KW  - CELL cycle
KW  - CELL death
KW  - PROTEIN kinases
KW  - TUMOR necrosis factor
KW  - apoptosis
KW  - Bcl-2
KW  - caspase
KW  - Fas
N1  - Accession Number: 11352202; Kawahara, Atsuo 1,2,3 Kobayashi, Toshiko 4 Nagata, Shigekazu 1,2; Affiliation:  1: Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan  2: Department of Genetics, Osaka University Medical School, B3, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan  3: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Building 6B, Room 420, NIH, Bethesda, Maryland 20892, USA  4: Ina Laboratories, MBL Co. Ltd, Oohara, 1063-103 Terasawaoka, Ina, Nagano 396-0002, Japan; Source Info: 11/19/98, Vol. 17 Issue 20, p2549; Subject Term: APOPTOSIS; Subject Term: CELL cycle; Subject Term: CELL death; Subject Term: PROTEIN kinases; Subject Term: TUMOR necrosis factor; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: Bcl-2; Author-Supplied Keyword: caspase; Author-Supplied Keyword: Fas; Number of Pages: 6p; Illustrations: 3 Diagrams, 1 Graph; Document Type: Article
L3  - 10.1038/sj.onc.1202192
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sheikh, M Saeed
AU  - Antinore, Michael J.
AU  - Ying Huang
AU  - Fornace Jr., Albert J.
T1  - Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1.
JO  - Oncogene
JF  - Oncogene
Y1  - 1998/11/19/
VL  - 17
IS  - 20
M3  - Article
SP  - 2555
EP  - 2563
PB  - Nature Publishing Group
SN  - 09509232
AB  - Ultraviolet (UV)-irradiation has been shown to induce jun N-terminal kinase activity via aggregation-mediated activation of tumor necrosis factor receptor 1 (TNFR1) but the role of TNFR1 in mediating UV-induced apoptosis has not been explored. Using p53-null cells, we demonstrate that UV-stimulated ligand independent activation of TNFR1 plays a major role in mediating the apoptotic effects of UV-irradiation. UV-irradiation and TNFα acted in a synergistic manner to induce apoptosis. UV-irradiation stimulated the aggregation-mediated activation of TNFR1 which was coupled with activation of caspase 8, the most proximal caspase in TNFα signaling pathway. CrmA and the dominant negative versions of FADD, caspase 8 and caspase 10, that block the apoptotic axis of TNFR1 at different levels, also independently inhibited the UV-induced apoptosis. The engagement of the membrane initiated events was specific for UV-irradiation since neither CrmA nor the dominant negative FADD, caspase 8 or caspase 10 blocked the ionizing radiation-induced apoptosis. Cisplatin and melphalan, the UV-mimetic agents known to elicit UV-type DNA damage, also induced apoptosis but differed from UV in that both of the former agents engaged the caspase cascade at a level distal to FADD. Consistent with these findings cisplatin also did not stimulate TNFR1 aggregation. Together these results indicate that DNA damage per se was not sufficient to activate the membrane TNFR1. Based on our results we propose that the plasma membrane initiated events play a predominant role in mediating UV-irradiation-induced apoptosis and that UV-irradiation appears to engage the apoptotic axis of TNFR1 and perhaps those of other membrane death receptors to transduce its apoptotic signals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ULTRAVIOLET radiation
KW  - IRRADIATION
KW  - TUMOR necrosis factor
KW  - DNA damage
KW  - APOPTOSIS
KW  - caspase cascade
KW  - TNFα
KW  - UV
N1  - Accession Number: 11352194; Sheikh, M Saeed 1 Antinore, Michael J. 1 Ying Huang 2 Fornace Jr., Albert J. 1; Affiliation:  1: Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892  2: Laboratory of Biological Chemistry, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA; Source Info: 11/19/98, Vol. 17 Issue 20, p2555; Subject Term: ULTRAVIOLET radiation; Subject Term: IRRADIATION; Subject Term: TUMOR necrosis factor; Subject Term: DNA damage; Subject Term: APOPTOSIS; Author-Supplied Keyword: caspase cascade; Author-Supplied Keyword: TNFα; Author-Supplied Keyword: UV; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 9p; Illustrations: 1 Color Photograph, 1 Diagram, 6 Graphs; Document Type: Article
L3  - 10.1038/sj.onc.1202292
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cannon III, Richard O.
T1  - Potential Mechanisms for the Effect of Angiotensin-Converting Enzyme Inhibitors on Endothelial Dysfunction: The Role of Nitric Oxide.
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
Y1  - 1998/11/20/
VL  - 82
M3  - Article
SP  - 8S
EP  - 10S
SN  - 00029149
AB  - The article discusses the role of nitric oxide (NO) and angiotensin converting enzymes (ACE) inhibitors in endothelia function and provides an answer to a question of NO estimation in human. Topics discussed include NO synthesis inhibition by L-N-monomethyl arginine (L-NMMA), regulation of NO activity by acetylcholine, ACE inhibitors mechanisms such as angiotensin II synthesis and bradykinin breakdown inhibition, NO mediated vasodilator responses and NO estimation by brachial artery dilation.
KW  - ACE inhibitors
KW  - ENDOTHELIUM -- Diseases
KW  - NITRIC oxide -- Regulation
KW  - NITRIC oxide -- Synthesis
KW  - NITRIC oxide -- Physiological effect
KW  - THERAPEUTIC use
N1  - Accession Number: 108873131; Cannon III, Richard O. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland; Source Info: 11/20/1998, Vol. 82, p8S; Subject Term: ACE inhibitors; Subject Term: ENDOTHELIUM -- Diseases; Subject Term: NITRIC oxide -- Regulation; Subject Term: NITRIC oxide -- Synthesis; Subject Term: NITRIC oxide -- Physiological effect; Subject Term: THERAPEUTIC use; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Quyyumi, Arshed A.
T1  - Effects of Aspirin on Endothelial Dysfunction in Atherosclerosis.
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
Y1  - 1998/11/20/
VL  - 82
M3  - Article
SP  - 31S
EP  - 33S
SN  - 00029149
AB  - The article focuses on a study related to the aspirin effect on endothelial function in atherosclerosis or its risk factors and provides answers of questions related to intravenous infused aspirin administration and prostacyclin mediated vasodilation. Topics discussed include vasodilator effect or paradoxical vasoconstriction by acetylcholine in presence of atherosclerosis, aspirin induced inhibition of superoxide generation and aspirin effect on acetylcholine mediated vasodilation.
KW  - ASPIRIN -- Physiological effect
KW  - ASPIRIN
KW  - ENDOTHELIUM -- Diseases
KW  - ATHEROSCLEROSIS
KW  - VASODILATION
KW  - PROSTACYCLIN
KW  - THERAPEUTIC use
KW  - RISK factors
N1  - Accession Number: 108873137; Quyyumi, Arshed A. 1; Affiliation:  1: National Institutes of Health, Bethesda, Maryland; Source Info: 11/20/1998, Vol. 82, p31S; Subject Term: ASPIRIN -- Physiological effect; Subject Term: ASPIRIN; Subject Term: ENDOTHELIUM -- Diseases; Subject Term: ATHEROSCLEROSIS; Subject Term: VASODILATION; Subject Term: PROSTACYCLIN; Subject Term: THERAPEUTIC use; Subject Term: RISK factors; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Guadagno, Mary Ann
AU  - Herrmann, Douglas
T1  - Further consideration of the role of socio-economic status in memory performance.
JO  - Applied Cognitive Psychology
JF  - Applied Cognitive Psychology
Y1  - 1998/12//
VL  - 12
IS  - 6
M3  - Article
SP  - 611
EP  - 616
PB  - John Wiley & Sons, Inc.
SN  - 08884080
AB  - In his commentary, Richardson criticizes the analysis of the relationship between socio-economic status (SES) and memory performance as presented by Herrmann and Guadagno (1997). Richardson's criticism addresses Herrmann and Guadagno's procedures for classifying economic backgrounds of subjects and the statistics they used to analyze the effects of SES and memory. We believe that all of these points are worth considering but suggest that it is too early in this research area to definitively settle on either (a) the best procedure for classifying SES or (b) the most effective statistical method for post-hoc analysis of memory data. The underlying issues are too complex and the number of investigations too few to argue that one procedure or method is right and the other wrong. Alternatively, Richardson's commentary agrees with ours in two important ways. Richardson's article and ours both assert that economic background is clearly a relevant variable in explaining memory performance. In addition, both articles recommend that memory and cognitive researchers take account of economic well being in future memory research. Copyright © 1998 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Applied Cognitive Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL status
KW  - MEMORY
KW  - COGNITION
KW  - COGNITIVE ability
N1  - Accession Number: 11818176; Guadagno, Mary Ann 1 Herrmann, Douglas 2; Affiliation:  1: National Institute for Aging, USA  2: Indiana State University, USA; Source Info: Dec1998, Vol. 12 Issue 6, p611; Subject Term: SOCIAL status; Subject Term: MEMORY; Subject Term: COGNITION; Subject Term: COGNITIVE ability; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
AU  - Heck, A. M.;
AU  - Young, L. R.;
AU  - Mohassel, M. R.;
T1  - Algorithm for detecting, evaluating, and managing potential drug interactions
CT  - Algorithm for detecting, evaluating, and managing potential drug interactions
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1998/12/01/
VL  - 33
IS  - Dec
SP  - P
EP  - D
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1N-257 (MSC 1196), Bethesda, MD 20892, USA
N1  - Accession Number: 35-12558; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice; Drug Interactions
N2  - Pharmacists can play an important role in providing patient-specific recommendations that can assist in the prompt detection, evaluation, and management of drug interactions. Unfortunately, most pharmacists have not been adequately prepared for this role and often do not have the necessary tools to achieve this important task. Several specialized drug interaction resources are widely available and readily accessible to most pharmacists. While such resources contain valuable information regarding drug interactions, they do not provide pharmacists with a consistent, organized approach for prompt and effective patient management. Ineffective evaluation and management of drug interactions can compromise the quality of patient care. Our goal is to develop an algorithm that can provide pharmacists with a tool to systematically detect, evaluate, and manage drug interactions. The algorithm will address pertinent patient, disease, and drug factors that pharmacists should routinely evaluat . It will also identify management options that should be considered when drug interactions are encountered.
KW  - Practice Interest Areas--General Clinical Practice--meeting presentations;
KW  - ASHP meeting abstracts--drug interactions, pharmacists role;
KW  - Quality assurance--hospital pharmacy--drug interactions;
KW  - Pharmacy, institutional, hospital--quality assurance--drug interactions;
KW  - Administration--hospital pharmacy--drug interactions;
KW  - Pharmacy services--quality assurance--drug interactions;
KW  - Drug interactions--pharmacists, hospital--role;
KW  - Pharmacists, hospital--role--drug interactions;
KW  - Patient care--drug interactions--pharmacists role;
KW  - Protocols--algorithms--drug interactions;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goldspiel, B. R.;
T1  - Cancer gene therapy update
CT  - Cancer gene therapy update
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1998/12/01/
VL  - 33
IS  - Dec
SP  - PI
EP  - 56
AD  - Pharmacy Department, NIH Clinical Center, Building 10, Room 1N-257, Bethesda, MD 20892-1196, USA Internet: bgoldspiel@nih.gov
N1  - Accession Number: 35-13057; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Drug Evaluations
N2  - The discovery and application of biologic therapy to treat human cancers have provided insight into the many possible approaches to using gene therapy for the diagnosis and treatment of cancer and monitoring of cancer therapy. Exogenous genes may be used to mark cells (e.g. peripheral blood or bone marrow stem cells, tumor infiltrating lymphocytes) to help better understand cancer biology. Approaches using gene therapy for cancer treatment include: using lymphocytes as gene carriers (e.g. TNF-TIL); using foreign genes to increase tumor immunogenicity (e.g. TNF-Tumor or HLA B7-Tumor); introducing sensitivity genes to produce new cytotoxic agent(s) within tumors (e.g. HSV-TK in brain tumors); producing new protein product(s) to protect normal cells (e.g. chemoresistance gene MDR-1); replacing missing or mutant tumor suppressor genes (e.g. p53 in lung cancer); and inactivating oncogenes (e.g. K-ras in lung cancer). This talk will summarize the current applications of human gene ther py for cancer. Learning objectives: 1. Describe how gene transfer techniques may be used to better understand cancer biology. 2. Discuss the clinical implications of how gene transfer has changed the approach to treating pediatric patients with acute myelogenous leukemia and neuroblastoma. 3. Discuss the various strategies and clinical data supporting gene therapy for cancer treatment. Self-assessment questions: 1. (Multiple Choice) Gene addition techniques for the treatment of cancer include: a. TNF gene to TIL; b. p53 to lung cancer; c. HLA-B7 to melanoma cells using liposomes; d. all of the above. 2. (True or False) Studies have demonstrated that reinfused bone marrow can be a source of relapse in pediatric patients with acute myelogenous leukemia. 3. (Multiple Choice) Virally directed enzyme prodrug therapy: a. is also known as suicide or sensitivity gene therapy; b. causes preferential tumor cell death; c. inhibits viral replication in man; d. a and b only. Answers: 1. d; 2. T; 3. d.
KW  - ASHP meeting abstracts--oncology, gene therapy;
KW  - Neoplasms--gene therapy--overview;
KW  - Antineoplastic agents--neoplasms--gene therapy;
KW  - Gene therapy--neoplasms--overview;
KW  - Diagnosis--neoplasms--gene therapy;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=35-13057&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107159506
T1  - Inherited predisposition to colon cancer.
AU  - Glaser EM
Y1  - 1998/12//1998 Dec
N1  - Accession Number: 107159506. Language: English. Entry Date: 19990201. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; glossary; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7805358. 
KW  - Colorectal Neoplasms
KW  - Adenomatous Polyposis Coli
KW  - Neoplastic Syndromes, Hereditary
KW  - Mutation
KW  - Colorectal Neoplasms -- Epidemiology
KW  - Colorectal Neoplasms -- Physiopathology
KW  - Colorectal Neoplasms -- Diagnosis
KW  - Genetics
KW  - Education, Continuing (Credit)
KW  - Genes
KW  - Cancer Screening
KW  - Genetic Screening
KW  - Adult
KW  - Middle Age
SP  - 377
EP  - 384
JO  - Cancer Nursing
JF  - Cancer Nursing
JA  - CANCER NURS
VL  - 21
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Colorectal cancer is one of the most common malignancies in the United States. Although both genetic and environmental factors play a role in colorectal tumorigenesis, recent advances in genetics have more clearly defined the impact of inheritance in the multistep process of the disease. Researchers have identified single genes that confer a susceptibility to familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). Because these genes are inherited in an autosomal dominant fashion, offspring of carriers have a 50% chance of inheriting the gene mutation and its associated risk. The FAP gene, when mutated, initiates the neoplastic process. HNPCC gene mutations disrupt mismatch repair, thus inducing progression of tumor formation. Discovery of these genes has helped our understanding of sporadic colon cancer as well. Genetic testing for the FAP and HNPCC genes is now available, and results of this testing have implications for surveillance and management. In addition, testing raises complex psychosocial and ethical issues. At present, genetic testing is primarily conducted in the research setting, but it will soon be available in the clinical arena. To prepare for the challenges that these new advances will present, nurses must begin now to enhance their knowledge of genetics and its application to oncology.
SN  - 0162-220X
AD  - National Naval Medical Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 9848995.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107159506&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kurtzman, Howard S.
AU  - Maser, Jack D
AU  - Ingram, Rick E.
T1  - Special Issue: Cognition and Anxiety.
JO  - Cognitive Therapy & Research
JF  - Cognitive Therapy & Research
Y1  - 1998/12//
VL  - 22
IS  - 6
M3  - Article
SP  - 535
PB  - Springer Science & Business Media B.V.
SN  - 01475916
AB  - Introduces the article appearing in the December 1998 issue of "Cognitive Therapy and Research." Attention biases towards threatening information associated with anxiety; Phenomenon of worrying; Brain structures affecting cognition.
KW  - PSYCHOLOGICAL literature
KW  - COGNITIVE therapy
KW  - RATIONAL emotive behavior therapy
N1  - Accession Number: 11306012; Kurtzman, Howard S. 1 Maser, Jack D 2 Ingram, Rick E.; Affiliation:  1: National Institute of Mental Health, Rockville, Maryland  2: San Diego State University, San Diego, California; Source Info: Dec1998, Vol. 22 Issue 6, p535; Subject Term: PSYCHOLOGICAL literature; Subject Term: COGNITIVE therapy; Subject Term: RATIONAL emotive behavior therapy; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nash, W.G.
AU  - Wienberg, J.
AU  - Ferguson-Smith, M.A.
AU  - Menninger, J.C.
AU  - O'brien, S.J.
T1  - Comparative genomics: tracking chromosome evolution in the family Ursidae using reciprocal chromosome painting.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/12//
VL  - 83
IS  - 3/4
M3  - Article
SP  - 182
EP  - 192
SN  - 03010171
AB  - The Ursidae family includes eight species, the karyotype of which diverges somewhat, in both chromosome number and morphology, from that of other families in the order Carnivora. The combination of consensus molecular phylogeny and high-resolution trypsin G-banded karyotype analysis has suggested that ancestral chromosomal fissions and at least two fusion events are associated with the development of the different ursid species. Here, we revisit this hypothesis by hybridizing reciprocal chromosome painting probes derived from the giant panda (Ailuropoda melanoleuca), domestic cat (Felis catus), and man (Homo sapiens) to representative bear species karyotypes. Comparative analysis of the different chromosome segment homologies allowed reconstruction of the genomic composition of a putative ancestral bear karyotype based upon the recognition of 39 chromosome segments defined by painting as the s mallest c onserved e volutionary u nit s egments (pSCEUS) among these species. The different pSCEUS combinations occurring among modern bear species support and extend the postulated sequence of chromosomal rearrangements and provide a framework to propose patterns of genome reorganization among carnivores and other mammal radiations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cytogenetics & Cell Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BEARS
KW  - KARYOTYPES
KW  - CHROMOSOMES
KW  - HYBRIDIZATION
KW  - GENOMICS
KW  - CARNIVORA
N1  - Accession Number: 12184389; Nash, W.G. 1 Wienberg, J. 1 Ferguson-Smith, M.A. 2 Menninger, J.C. 3 O'brien, S.J. 4; Email Address: obrien@ncifcrf.gov; Affiliation:  1: H &emp; Cytogenetic Services, Inc., Lovettsville, VA (USA).  2: Department of Pathology, Cambridge University, Cambridge (UK).  3: Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center (NCI-FCRDC), Frederick, MD (USA).  4: Laboratory of Genomic Diversity, NCI-FCRDC, Frederick, MD (USA).; Source Info: Dec98, Vol. 83 Issue 3/4, p182; Subject Term: BEARS; Subject Term: KARYOTYPES; Subject Term: CHROMOSOMES; Subject Term: HYBRIDIZATION; Subject Term: GENOMICS; Subject Term: CARNIVORA; Number of Pages: 11p; Document Type: Article
L3  - 10.1159/000015176
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12184389&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jensen, M.R.
AU  - Audolfsson, T.
AU  - Keck, C.L.
AU  - Zimonjic, D.B.
AU  - Thorgeirsson, S.S.
T1  - Assignment<FOOTREF>[sup 1] </FOOTREF> of the cyclin I gene (Ccni) to mouse chromosome 5E3.3–F1.3 by in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1998/12//
VL  - 83
IS  - 3/4
M3  - Article
SP  - 242
EP  - 243
SN  - 03010171
AB  - This article studies the assignment of the cyclin I gene (Ccni) to mouse chromosome 5E3.3-F1.3 by in situ hybridization. Cyclins are essential activators of cyclin-dependent kinases that mediate transition through the cell cycle. To examine the cyclin I gene was mapped to mouse chromosome 5 E3. 3-Fl .3. Co-localization by two-color FISH analysis of cyclin G2 and I show that hybridization signals are inseparable in interphase nuclei with diffuse and relatively decondensed chromatin as well as in more extended prometaphase chromosomes.
KW  - GENE mapping
KW  - CYCLIN-dependent kinases
KW  - CELL cycle
KW  - IN situ hybridization
KW  - CHROMATIN
KW  - MICE
N1  - Accession Number: 12184373; Jensen, M.R. 1 Audolfsson, T. 1 Keck, C.L. 1 Zimonjic, D.B. 1 Thorgeirsson, S.S. 1; Email Address: snorri_thorgeirsson@nih.gov; Affiliation:  1: Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD (USA).; Source Info: Dec98, Vol. 83 Issue 3/4, p242; Subject Term: GENE mapping; Subject Term: CYCLIN-dependent kinases; Subject Term: CELL cycle; Subject Term: IN situ hybridization; Subject Term: CHROMATIN; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000015192
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12184373&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Feldman-Naim, Susana
AU  - Lowe, Catherine H.
AU  - Myers, Frances S.
AU  - Turner, Erick H.
AU  - Weinstock, Lauren M.
AU  - Leibenluft, Ellen
T1  - Validation of the hypomania interview guide-seasonal affective disorder (HIGH-SAD) version in patients with rapid cycling bipolar disorder.
JO  - Depression & Anxiety (1091-4269)
JF  - Depression & Anxiety (1091-4269)
Y1  - 1998/12//
VL  - 8
IS  - 4
M3  - Article
SP  - 166
EP  - 168
PB  - John Wiley & Sons, Inc.
SN  - 10914269
AB  - We validated the Hypomania Interview Guide-Seasonal Affective Disorder (HIGH-SAD) version in patients with rapid cycling bipolar disorder (RCBD). Fourteen outpatients were rated on six separate occasions (total= 84 visits). On each visit the patients were rated with the HIGH-SAD and the Young Mania Rating Scale (YMRS) in a counterbalanced order. Clinical assessment was completed at the end of the visit by the treating psychiatrist. Patients were assessed as hypomanic/manic on 22 of the visits. Pearson correlation coefficient between the YMRS total scores and the HIGH-SAD total scores for those 22 visits in which patients were hypomanic/manic was r= 0.629 (P < 0.05) and for all visits was r= 0.769 (P <0.0001). Analysis with only one rating per patient yielded a Pearson correlation coefficient of r=0.792 (P <0.0004). We found that the HIGH-SAD was a valid scale for the measurement of hypomania in patients with RCBD. However, the scale does not differentiate hypomania from mania in this group of patients. Depression and Anxiety 8:166–168, 1998. Published 1998 Wiley-Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Depression & Anxiety (1091-4269) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYPOMANIA
KW  - VALIDATION therapy
KW  - AFFECTIVE disorders
KW  - INTERVIEWING in mental health
KW  - SEASONAL affective disorder
KW  - bipolar disorder
KW  - hypomania
KW  - rapid cycling
N1  - Accession Number: 11772809; Feldman-Naim, Susana 1 Lowe, Catherine H. 1 Myers, Frances S. 1 Turner, Erick H. 1 Weinstock, Lauren M. 1 Leibenluft, Ellen 1; Affiliation:  1: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland; Source Info: 1998, Vol. 8 Issue 4, p166; Subject Term: HYPOMANIA; Subject Term: VALIDATION therapy; Subject Term: AFFECTIVE disorders; Subject Term: INTERVIEWING in mental health; Subject Term: SEASONAL affective disorder; Author-Supplied Keyword: bipolar disorder; Author-Supplied Keyword: hypomania; Author-Supplied Keyword: rapid cycling; Number of Pages: 3p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11772809&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lloyd, Ray D.
AU  - Taylor, Glenn N.
AU  - Mays, Charles W.
T1  - 241Am REMOVAL BY DTPA vs. OCCURRENCE OF SKELETAL MALIGNANCY.
JO  - Health Physics
JF  - Health Physics
Y1  - 1998/12//
VL  - 75
IS  - 6
M3  - Article
SP  - 640
EP  - 645
SN  - 00179078
AB  - Beagle dogs injected with 241Am and treated subsequently with DTPA exhibited a reduced occurrence of skeletal malignancies and increased lifespans when compared to corresponding untreated animals also given 241Am. Whereas 92% of dogs given about 11 kBq 241Am kg-1 and not treated with DTPA developed bone cancer (skeletal dose about 5.9 Gy), skeletal malignancy was seen in only 40% and 27%, respectively, among two groups of DTPA-treated animals injected with 11 kBq kg-l (doses of 5.7 and 1.7 Gy). The median lifespan among the untreated dogs was 1,728 d, but the median lifespans in the DTPA-treated groups were 2,478 and 3,654 d, respectively. Untreated dogs with a skeletal dose averaging about 2 Gy had 53% bone cancer occurrence and a median lifespan of 3,227 d. These data did not enable us to address the question of whether the reduction in cancer occurrence was proportional to, greater than, or less than the reduction in skeletal dose, but the third possibility seems unlikely. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Health Physics is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - 241Am
KW  - cancer
KW  - dogs
KW  - neoplasms
N1  - Accession Number: 102393125; Lloyd, Ray D. 1; Taylor, Glenn N. 1; Mays, Charles W. 2; Affiliations: 1: University of Utah, Radiobiology Laboratory, 40 N 2030 E Front, Salt Lake City, UT 841 12-5860; 2: Deceased; formerly with the National Cancer Institute Bethesda, MD.; Issue Info: Dec1998, Vol. 75 Issue 6, p640; Author-Supplied Keyword: 241Am; Author-Supplied Keyword: cancer; Author-Supplied Keyword: dogs; Author-Supplied Keyword: neoplasms; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Portier, C.J.
AU  - Ye, F.
T1  - U-shaped dose-response curves for carcinogens.
JO  - Human & Experimental Toxicology
JF  - Human & Experimental Toxicology
Y1  - 1998/12//
VL  - 17
IS  - 12
M3  - Article
SP  - 705
EP  - 707
PB  - Sage Publications, Ltd.
SN  - 09603271
AB  - Examines the theoretical justification which supports hormesis or U-shaped dose-response in carcinogens.  Other justifications which support the concept that increasing doses of a chemical or physical agent will result in decreasing  cancer risk at the lowest doses; Statistical and scientific challenges facing the validity of hormesis; Analysis of the data on U-shaped dose-response curves; Information on the dominant dose-response relationships for cancer risk assessment.
KW  - Carcinogens
KW  - Health risk assessment
KW  - Hormesis
KW  - Cancer
KW  - cancer
KW  - dose-response
KW  - mathematical modeling
KW  - risk assessment
N1  - Accession Number: 4664083; Portier, C.J. 1; Ye, F. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Laboratory of Computational Biology and Risk Analysis, Research Triangle Park, North Carolina 27709, USA; Issue Info: 1998, Vol. 17 Issue 12, p705; Thesaurus Term: Carcinogens; Thesaurus Term: Health risk assessment; Subject Term: Hormesis; Subject Term: Cancer; Author-Supplied Keyword: cancer; Author-Supplied Keyword: dose-response; Author-Supplied Keyword: mathematical modeling; Author-Supplied Keyword: risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107169002
T1  - When is the dyspnea worth it? Understanding functional performance in people with alpha-1 antitrypsin deficiency.
AU  - Knebel A
AU  - Leidy NK
AU  - Sherman S
Y1  - 1998/12//
N1  - Accession Number: 107169002. Language: English. Entry Date: 19990301. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Chronic Respiratory Disease Questionnaire (CRQ) (Guyatt et al). NLM UID: 8400753. 
KW  - Emphysema
KW  - Quality of Life
KW  - Hereditary Diseases
KW  - Connective Tissue Diseases
KW  - Activities of Daily Living
KW  - Research Instruments
KW  - Exploratory Research
KW  - Interrater Reliability
KW  - Secondary Analysis
KW  - Lung Diseases, Obstructive
KW  - Descriptive Statistics
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 339
EP  - 343
JO  - Image: Journal of Nursing Scholarship
JF  - Image: Journal of Nursing Scholarship
JA  - IMAGE J NURS SCHOLARSH
VL  - 30
IS  - 4
CY  - Indianapolis, Indiana
PB  - Sigma Theta Tau International
AB  - OBJECTIVE AND SIGNIFICANCE: To examine functional performance in people with emphysema because of alpha-1 antitrypsin (AAT) deficiency. A severe deficiency of AAT affects 1:3,500 to 1:1,670 Americans who can develop debilitating emphysema in the third to fifth decades of life. DESIGN: Exploratory. POPULATION: People with a severe deficiency of AAT. SAMPLE AND DEMOGRAPHICS: Thirty-three patients (21 men) with a mean age of 47 (SD = 7) years. YEARS: Data were collected 1993-1996. METHODS: Activities patients identified as important on the dyspnea subscale of the Chronic Respiratory Disease Questionnaire were categorized and interpreted within the context of an integrity framework (i.e., effectiveness--or connectedness-related). FINDINGS: Patients identified over 25 activities. Effectiveness activities, such as bathing, were mentioned most frequently (78%). Connectedness activities, such as playing with children, were mentioned less often (22%) but were ranked more important. Two patients reviewed and supported the content validity of the framework. CONCLUSIONS: Results offer insight into the activities patients with genetic emphysema choose to perform and the factors that influence the decision that 'the dyspnea is worth it.' IMPLICATIONS: Identifying the activities people with AAT deficiency choose to perform and understanding why these activities are meaningful can guide interventions to help patients maintain a sense of integrity.
SN  - 0743-5150
AD  - Clinical Center Nursing Department, Bldg. 10, Room 2C206, 10 Center Dr. MSC 1506, Bethesda, MD 20892-1506; e-mail: aknebel@nih.gov
U2  - PMID: 9866294.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Pascualvaca, Daisy M.
AU  - Fantie, Bryan D.
AU  - Papageorgiou, Maria
AU  - Mirsky, Allan F.
T1  - Attentional Capacities in Children with Autism: Is There a General Deficit in Shifting Focus?
JO  - Journal of Autism & Developmental Disorders
JF  - Journal of Autism & Developmental Disorders
Y1  - 1998/12//
VL  - 28
IS  - 6
M3  - Article
SP  - 467
PB  - Springer Science & Business Media B.V.
SN  - 15733432
AB  - Twenty-three children with autism and two control groups completed an attention battery comprising three versions of the continuous performance test (CPT), a digit cancellation task, the Wisconsin Card Sorting Test (WCST), and two novel, computerized tests of shifting attention (i.e., the Same–Different Computerized Task and the Computerized Matching Task). Children with autism could focus on a particular stimulus and sustain this focus as indicated by their performance on the digit cancellation task and the CPT. Their performance on the WCST suggested problems in some aspects of shifting attention (i.e., disengaging attention). The autism group performed as well as controls on the Same–Different Computerized Task, however, that required successive comparisons between stimuli. This implies that they could, in fact, shift their attention continuously. In addition, they did not differ from controls on the Computerized Matching Task, an analog of the WCST, suggesting that they do not have a general deficit in shifting attention. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Autism & Developmental Disorders is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTISM in children
KW  - INTERPERSONAL relations
KW  - ATTENTION
KW  - Attention deficit
KW  - autism
KW  - shifting focus
N1  - Accession Number: 11305412; Pascualvaca, Daisy M. 1 Fantie, Bryan D. 1,2 Papageorgiou, Maria 1 Mirsky, Allan F. 1; Affiliation:  1: Section on Clinical and Experimental Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, Maryland  2: Human Neuropsychology Laboratory, Department of Psychology, The American University, Washington, DC; Source Info: Dec1998, Vol. 28 Issue 6, p467; Subject Term: AUTISM in children; Subject Term: INTERPERSONAL relations; Subject Term: ATTENTION; Author-Supplied Keyword: Attention deficit; Author-Supplied Keyword: autism; Author-Supplied Keyword: shifting focus; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107143507
T1  - Gender and drug abuse research.
AU  - Millstein RA
Y1  - 1998/12//1998 Dec
N1  - Accession Number: 107143507. Language: English. Entry Date: 20001101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 100887298. 
KW  - Research
KW  - Substance Abuse
KW  - Gender Bias
KW  - Female
KW  - Male
KW  - Substance Abuse -- Organizations
KW  - National Institutes of Health (U.S.)
KW  - Substance Dependence
KW  - Cocaine
KW  - Recurrence
KW  - Genetics
KW  - Smoking
KW  - HIV Infections
SP  - 44
EP  - 47
JO  - Journal of Gender-Specific Medicine
JF  - Journal of Gender-Specific Medicine
JA  - J GENDER SPECIFIC MED
VL  - 1
IS  - 3
CY  - Malvern, Pennsylvania
PB  - MultiMedia HealthCare
SN  - 1523-7036
AD  - Deputy Director, National Institute on Drug Abuse, National Institutes of Health, 5600 Fishers Ln, Room 1005, Rockville, MD 20857
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bouras, N.
AU  - Dykens, E. M.
AU  - Smith, A. C. M.
T1  - Distinctiveness and correlates of maladaptive behaviour in children and adolescents with Smith–Magenis syndrome.
JO  - Journal of Intellectual Disability Research
JF  - Journal of Intellectual Disability Research
Y1  - 1998/12//
VL  - 42
IS  - 6
M3  - Article
SP  - 481
EP  - 489
PB  - Wiley-Blackwell
SN  - 09642633
AB  - Abstract This two-part study examines the distinctiveness and correlates of maladaptive behaviour in 35 children and adolescents with Smith–Magenis syndrome, a developmental disorder caused by an interstitial deletion of chromosome 17 (p11.2). Study I compares Child Behavior Checklist scores in 35 children with Smith–Magenis syndrome to age- and gender-matched subjects with Prader–Willi syndrome and mixed intellectual disability. Subjects with Smith–Magenis syndrome had significantly higher levels of maladaptive behaviour than the other groups. Although some problems were shared across groups, 12 behaviours differentiated the three groups with 100% accuracy. Study 2 assessed the frequency and correlates of self-injurious and stereotypical behaviours, including unusual features such as nail-yanking, inserting objects into bodily orifices, self-hugging and a ‘lick-and flip’ behaviour. Nail-yanking and bodily insertions were less common than other types of self-injury, and self-hugs and the ‘lick-and flip’ stereotypies were seen in about half the sample. Although age and degree of delay were correlated with problem behaviours, sleep disturbance emerged as the strongest predictor of maladaptive behaviour. The implications are discussed for clinical diagnostic ambiguities between the Smith–Magenis and Prader–Willi syndromes, and for intervention. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SYNDROMES
KW  - CRANIOFACIAL dysostosis
KW  - maladaptive behaviour
KW  - Self-injurious behaviour
KW  - Smith–Magenis syndrome
N1  - Accession Number: 6137101; Bouras, N. Dykens, E. M. 1 Smith, A. C. M. 2; Affiliation:  1: University of California at Los Angeles, Neuropsychiatric Institute, Los Angels, California  2: Medical Genetics Branch, National Human Genome Research Institue, National Institutes of Health, USA; Source Info: Dec1998, Vol. 42 Issue 6, p481; Subject Term: SYNDROMES; Subject Term: CRANIOFACIAL dysostosis; Author-Supplied Keyword: maladaptive behaviour; Author-Supplied Keyword: Self-injurious behaviour; Author-Supplied Keyword: Smith–Magenis syndrome; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
L3  - 10.1046/j.1365-2788.1998.4260481.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=6137101&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Regier, Darrel A.
AD  - National Institute of Mental Health, Bethesda, MD
T1  - Mental Health Economics
JO  - Journal of Mental Health Policy and Economics
JF  - Journal of Mental Health Policy and Economics
Y1  - 1998/12//
VL  - 1
IS  - 4
SP  - 205
EP  - 207
SN  - 10914358
N1  - Accession Number: 0627402; Keywords: Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200211
KW  - Analysis of Health Care Markets          I11
L3  - http://www.icmpe.org/test1/journal/journal.htm
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0627402&site=ehost-live&scope=site
UR  - http://www.icmpe.org/test1/journal/journal.htm
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 107166173
T1  - Facing the new century with the National Institute of Dental and Craniofacial Research.
AU  - Slavkin HC
Y1  - 1998/12//
N1  - Accession Number: 107166173. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Research, Dental -- Organizations
KW  - Abnormalities
KW  - Research, Dental -- History
KW  - Research, Dental -- Trends
KW  - Genetics
SP  - 1760
EP  - 1763
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 129
IS  - 12
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - Director, National Institute of Dental and Craniofacial Research, 31 Center Dr, MSC 2290, Building 31, Room 2C39, Bethesda, Md 20892-2290
U2  - PMID: 9854930.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107180234
T1  - The genetic origins of ovarian failure.
AU  - Bondy CA
AU  - Nelson LM
AU  - Kalantaridou SN
Y1  - 1998/12//
N1  - Accession Number: 107180234. Language: English. Entry Date: 19990401. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978. 
KW  - Menopause, Premature -- Etiology
KW  - Menopause, Premature -- Familial and Genetic
KW  - Chromosome Disorders
KW  - Autoimmune Diseases
KW  - Genetics
KW  - Female
KW  - Adult
SP  - 1225
EP  - 1229
JO  - Journal of Women's Health
JF  - Journal of Women's Health
JA  - J WOMENS HEALTH
VL  - 7
IS  - 10
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - Premature ovarian failure (POF) is a condition characterized by cessation of ovarian function before the age of 40. The recent meeting at the National Institute of Child Health and Human Development brought together experts from diverse disciplines to share current perspectives on the genetic and physiologic origins of POF, with the idea that insights gained from these studies may provide important clues about the regulation of normal ovarian aging and perhaps aging processes in general. It was suggested that several murine genes, including Zfx, c = kit, and the kit ligand, should be fertile candidates for investigation of the etiology of POF in human families. The specific roles of the human DIA and FMR1 gene products in germ cell development need clarification in murine models, and there are more as yet unidentified genes residing on the long arm of the X chromosome that are also implicated in the regulation of human ovarian function. Genes acting at later stages of oocyte or ovarian follicle function, such as gonadotropin hormones and receptors, are responsible for POF in some women. POF has been found to be a heterogeneous disorder, the dissection of which offers promising insights into mechanisms governing germ cell origination, migration, and proliferation, meiotic mechanisms, and factors governing oocyte maturation and survival.
SN  - 1059-7115
AD  - National Institutes of Health, 10 Center Drive MSC 1862, Building 10, Room 10N262, Bethesda, MD 20892-1862
U2  - PMID: 9929855.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Zheng, Feng
AU  - Striker, Gary E.
AU  - Esposito, Ciro
AU  - Lupia, Enrico
AU  - Striker, Liliane J.
T1  - Strain differences rather than hyperglycemia determine the severity of glomerulosclerosis in mice.
JO  - Kidney International
JF  - Kidney International
Y1  - 1998/12//
VL  - 54
IS  - 6
M3  - Article
SP  - 1999
EP  - 2007
SN  - 00852538
AB  - Strain differences rather than hyperglycemia determine the severity of glomerulosclerosis in mice. Background. We reported that ROP, but not C57, mice were prone to glomerulosclerosis (GS) after nephron reduction (J Clin Invest 97:1242, 1996). Methods. In this study, we induced diabetes in ROP and C57 mice to determine if the glomerulosclerotic response was stimulus specific. We used the oligosyndactyly mutation (Os), to produce a congenital 50% reduction in nephron number. Stable hyperglycemia was induced by streptozotocin and mice were maintained for 12 weeks without insulin treatment. Results. Glomerular hypertrophy occurred in diabetic ROP +/+ and C57 +/+ mice, but glomeruli of diabetic ROP +/+ mice had 1.92-fold higher laminin B1 and 1.5-fold higher tenascin mRNA levels than diabetic C57 +/+ mice. Diabetic ROP Os/+ mice had severe glomerulosclerosis with arteriolar and tubulointerstitial lesions while there was only moderate mesangial sclerosis in diabetic C57 Os/+ mice. Glomerular size was increased in all non-diabetic Os/+ mice. It was further increased in diabetic ROP Os/+ mice, but not in diabetic C57 Os/+ mice. Glomerular mRNA levels were higher in diabetic ROP OS/+ than in diabetic C57 OS/+ mice [α1 (IV) collagen 3.2-fold, laminin B1 2.1-fold, and tenascin 1.6-fold]. Conclusion. Overall, our data further support the hypothesis that the susceptibility to glomerulosclerosis is inherited, and suggest that hyperglycemia serves principally as a triggering event in the development of diabetic nephropathy. Since the acceleration of diabetic nephropathy by nephron reduction was also largely strain dependent, it appears that the propensity to glomerulosclerosis is a general renal response and is not stimulus specific. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIABETIC nephropathies
KW  - GENETICS
KW  - HYPERGLYCEMIA
KW  - KIDNEY glomerulus
KW  - GENETIC aspects
KW  - diabetes
KW  - glomerular lesions
KW  - insulin
KW  - nephropathy
KW  - sclerosis
KW  - susceptibility to GS
N1  - Accession Number: 5181530; Zheng, Feng 1,2,3 Striker, Gary E. 1,2,3 Esposito, Ciro 1,2,3 Lupia, Enrico 1,2,3 Striker, Liliane J. 1,2,3; Affiliation:  1: Renal Cell Biology Section, NIDDK, National Institutes of Health, Bethesda, Maryland,  2: Ivax Research Institute, Ivax Corporation,  3: Laboratory of Renal Cell Biology, Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA; Source Info: Dec1998, Vol. 54 Issue 6, p1999; Subject Term: DIABETIC nephropathies; Subject Term: GENETICS; Subject Term: HYPERGLYCEMIA; Subject Term: KIDNEY glomerulus; Subject Term: GENETIC aspects; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: glomerular lesions; Author-Supplied Keyword: insulin; Author-Supplied Keyword: nephropathy; Author-Supplied Keyword: sclerosis; Author-Supplied Keyword: susceptibility to GS; Number of Pages: 9p; Illustrations: 2 Color Photographs, 3 Diagrams, 3 Charts; Document Type: Article
L3  - 10.1046/j.1523-1755.1998.00219.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5181530&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nelson, Robert G.
AU  - Morgenstern, Hal
AU  - Bennett, Peter H.
T1  - An epidemic of proteinuria in Pima Indians with Type 2 diabetes mellitus.
JO  - Kidney International
JF  - Kidney International
Y1  - 1998/12//
VL  - 54
IS  - 6
M3  - Article
SP  - 2081
EP  - 2088
SN  - 00852538
AB  - An epidemic of proteinuria in Pima Indians with Type 2 diabetes mellitus. Background. The risk of proteinuria in Type 1 diabetes declined ≥30% over the past 50 years, and improvements in metabolic control are believed to be largely responsible. Little is known about secular changes in the risk of proteinuria in Type 2 diabetes. Methods . We examined trends in the incidence rate of proteinuria in Pima Indians ≥20 years of age with diabetes diagnosed between January 1, 1955 and December 31, 1994. Results . Among 1305 initially non-proteinuric diabetic subjects, 433 developed proteinuria during a median follow-up of 8.0 years (range 0.8 to 30.2 years). With subjects with diabetes diagnosed between 1955 and 1964 serving as the reference group, the rate of proteinuria was similar (rate ratio 1.0; 95% confidence interval, 0.79 to 1.3) in the cohort diagnosed between 1965 and 1974, 1.5 times as high (95% confidence interval, 1.1 to 2.0) in the cohort diagnosed between 1975 and 1984, and 1.9 times as high (95% confidence interval, 1.1 to 3.0) in the cohort diagnosed between 1985 and 1994, after adjusting for potential confounders in a generalized additive proportional hazards model. Between the first and last cohorts, plasma glucose concentration declined, on average, by 17% (P = 0.0001) and the mean arterial pressure declined by 11% (P = 0.0001). Conclusions . The incidence rate of proteinuria in Pima Indians with Type 2 diabetes increased nearly twofold in the last 40 years, despite improvements in plasma glucose and blood pressure. Rapidly changing environmental or behavioral factors must play an important role in the pathogenesis of diabetic renal disease in this population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PIMA (North American people)
KW  - DISEASES
KW  - PROTEINURIA
KW  - NON-insulin-dependent diabetes
KW  - RISK factors
KW  - blood pressure
KW  - Generalized additive models
KW  - heritage
KW  - incidence rates
KW  - Pima Indians
KW  - proteinuria
KW  - time-dependent proportional hazards analysis
N1  - Accession Number: 5181786; Nelson, Robert G. 1 Morgenstern, Hal 1 Bennett, Peter H. 1; Affiliation:  1: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, and Department of Epidemiology, School of Public Health, University of California, Los Angeles, California, USA.; Source Info: Dec1998, Vol. 54 Issue 6, p2081; Subject Term: PIMA (North American people); Subject Term: DISEASES; Subject Term: PROTEINURIA; Subject Term: NON-insulin-dependent diabetes; Subject Term: RISK factors; Author-Supplied Keyword: blood pressure; Author-Supplied Keyword: Generalized additive models; Author-Supplied Keyword: heritage; Author-Supplied Keyword: incidence rates; Author-Supplied Keyword: Pima Indians; Author-Supplied Keyword: proteinuria; Author-Supplied Keyword: time-dependent proportional hazards analysis; Number of Pages: 8p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3  - 10.1046/j.1523-1755.1998.00191.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107164135
T1  - Administering urokinase for catheter clearance.
AU  - Mayo DJ
Y1  - 1998/12//
N1  - Accession Number: 107164135. Language: English. Entry Date: 20050712. Revision Date: 20150820. Publication Type: Journal Article; pictorial; protocol. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137. 
KW  - Vascular Access Devices -- Adverse Effects
KW  - Catheter-Related Thrombosis -- Drug Therapy
KW  - Urokinase -- Therapeutic Use
KW  - Urokinase -- Administration and Dosage
KW  - Catheter Care, Vascular
SP  - 50
EP  - 52
JO  - Nursing
JF  - Nursing
JA  - NURSING
VL  - 28
IS  - 12
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - If your patient's central venous access device becomes occluded, follow these steps to restore patency.
SN  - 0360-4039
AD  - Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Md
U2  - PMID: 9987281.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kiler, C. M.
AU  - Roble, A. G.
AU  - Kolenbrander, P. E.
T1  - <em>Actinomyces</em> serovar WVA963 coaggregation-defective mutant strain PK2407 secretes lactose-sensitive adhesin that binds to coaggregation partner <em>Streptococcus oralis</em> 34.
JO  - Oral Microbiology & Immunology
JF  - Oral Microbiology & Immunology
Y1  - 1998/12//
VL  - 13
IS  - 6
M3  - Article
SP  - 337
EP  - 340
SN  - 09020055
AB  - <em>Actinomyces</em> serovar WVA963 strain PK1259 mediates intergeneric coaggregation with several oral streptococci. These lactose-inhibitable coaggregations appear to involve a 95-kDa putative actinomyces adhesin in complex with type 2 fimbriae. A coaggregation-defective strain PK2407 lacking type 2 fimbriae synthesizes the putative adhesin but appears unable to present it properly on its surface. Antiserum was raised against surface sonicates of PK2407 and was absorbed with a different coaggregation-defective mutant PK3092 that synthesizes type 2 fimbriae but no adhesin. This absorbed antiserum specifically blocked lactose-inhibitable coaggregation of wild-type strain PK1259 and <em>Streptococcus oralis</em> 34 and identified a 95-kDa protein in ammonium sulfate precipitates of culture supernatant of the coaggregation-defective mutant PK2407, The 95-kDa secreted protein was bound to the streptococcal partner cells and to lactose-agarose affinity beads and was released by lactose from both the affinity beads and partner, indicating that the secreted and precipitated protein is biochemically active and may mediate coaggregation with streptococci. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oral Microbiology & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Actinomyces
KW  - MORPHOLOGY
KW  - Actinomycetaceae
KW  - Streptococcus
KW  - Lactose
KW  - Pili (Microbiology)
KW  - Bacteria
KW  - <em>Actinomyces</em>
KW  - adhesin
KW  - coaggregation-defective mutant
N1  - Accession Number: 12590634; Kiler, C. M. 1; Roble, A. G. 1; Kolenbrander, P. E. 1; Affiliations: 1: Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA; Issue Info: Dec1998, Vol. 13 Issue 6, p337; Thesaurus Term: Actinomyces; Thesaurus Term: MORPHOLOGY; Thesaurus Term: Actinomycetaceae; Subject Term: Streptococcus; Subject Term: Lactose; Subject Term: Pili (Microbiology); Subject Term: Bacteria; Author-Supplied Keyword: <em>Actinomyces</em>; Author-Supplied Keyword: adhesin; Author-Supplied Keyword: coaggregation-defective mutant; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104799909
T1  - The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials.
AU  - Fulfaro, F
AU  - Casuccio, A
AU  - Ticozzi, C
AU  - Ripamonti, C
Y1  - 1998/12//1998 Dec
N1  - Accession Number: 104799909. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Bone Neoplasms -- Drug Therapy
KW  - Bone Neoplasms
KW  - Diphosphonates -- Therapeutic Use
KW  - Palliative Care
KW  - Bone Neoplasms -- Physiopathology
KW  - Clinical Trials
SP  - 157
EP  - 169
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 78
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy.
U2  - PMID: 9870569.
DO  - 10.1016/S0304-3959(98)00135-3
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107185618
T1  - Food allergy.
AU  - Metcalfe DD
Y1  - 1998/12//1998 Dec
N1  - Accession Number: 107185618. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463. 
KW  - Food Hypersensitivity
KW  - Food Hypersensitivity -- Physiopathology
KW  - Diagnosis, Differential
KW  - Food Hypersensitivity -- Etiology
SP  - 819
EP  - 829
JO  - Primary Care
JF  - Primary Care
JA  - PRIM CARE
VL  - 25
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Food allergies are immunologic reactions to food allergens or food components. Several distinct clinical entities fall under this term, including immediate-in-time allergic reactions, which are IgE-dependent and involve mast cells and basophils, and delayed-in-time reactions to foods, such as food-induced enterocolitis, which involve additional effector systems. Most food allergies are precipitated by a small number of foods. The diagnosis of these diseases depends on history, physical examination, specific diagnostic assays, and oral food challenge. The differential diagnosis of these diseases is extensive. Treatment of food allergies relies on identification of the food substance that induces the reaction and subsequent avoidance measures. When an individual inadvertently consumes food to which he or she is sensitized, pharmacologic treatment is available. Copyright (c) 1998 by W.B. Saunders Company
SN  - 0095-4543
AD  - Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD. E-mail: dean_metcalfe@nih.gov
U2  - PMID: 9735121.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107185618&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107189706
T1  - A comparison of federal definitions of severe mental illness among children and adolescents in four communities.
AU  - Narrow WE
AU  - Regier DA
AU  - Goodman SH
AU  - Rae DS
AU  - Roper MT
AU  - Bourdon KH
AU  - Hoven C
AU  - Moore R
Y1  - 1998/12//
N1  - Accession Number: 107189706. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Child Global Assessment Scale (CGAS); Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA). Grant Information: Supported by grants UO1-MH46725, UO1-MH46718, UO1-MH46717, and UO1-MH46732 from the National Institute of Mental Health. NLM UID: 9502838. 
KW  - Mental Disorders -- Classification
KW  - Mental Disorders -- Diagnosis
KW  - Affective Symptoms -- Diagnosis
KW  - Disability Evaluation
KW  - Cross Sectional Studies
KW  - Community Mental Health Services -- Utilization
KW  - Affective Symptoms -- Classification
KW  - Affective Symptoms -- Epidemiology
KW  - Comparative Studies
KW  - Surveys
KW  - Incidence
KW  - Mental Disorders -- Epidemiology
KW  - National Institute of Mental Health (U.S.)
KW  - Descriptive Statistics
KW  - Chi Square Test
KW  - DSM
KW  - Epidemiological Research
KW  - Psychotic Disorders -- Classification
KW  - Psychotic Disorders -- Diagnosis
KW  - Psychotic Disorders -- Epidemiology
KW  - P-Value
KW  - United States
KW  - Funding Source
KW  - Random Sample
KW  - Interviews
KW  - Open-Ended Questionnaires
KW  - Child
KW  - Adolescence
KW  - Male
KW  - Female
KW  - Human
SP  - 1601
EP  - 1608
JO  - Psychiatric Services
JF  - Psychiatric Services
JA  - PSYCHIATR SERV
VL  - 49
IS  - 12
CY  - Arlington, Virginia
PB  - American Psychiatric Publishing, Inc.
AB  - OBJECTIVE: Using data from an epidemiological survey, the study compared existing definitions of severe mental illness and serious emotional disturbance among children and adolescents to demonstrate the range of prevalence rates resulting from application of different definitions to the same population. METHODS: Three definitions of severe mental illness and serious emotional disturbance were applied to data from the Methods for the Epidemiology of Child and Adolescent Mental Disorders survey, with a sample of 1,285, conducted in 1991-1992 by the National Institute of Mental Health. The resulting proportions of cases identified, demographic characteristics, service use, and perceived need for services were compared. RESULTS: From 3 to 23 percent of the sampled youth met criteria for severe mental illness or serious emotional disturbance. From 40 percent to as many as 78 percent of the defined youth used a mental health service in the year before the survey. School and ambulatory specialty settings were used most frequently. Generally, more than half of the parents of children with severe mental illness or serious emotional disturbance thought that their child needed services. CONCLUSIONS: The prevalence and characteristics of severe mental illness and serious emotional disturbance among children are sensitive to the definition used and its operationalization. Care should be taken by policy makers and service planners to avoid either over- or underestimating the prevalence of impaired youth in need of intensive interventions.
SN  - 1075-2730
AD  - National Institute of Mental Health, 31 Center Drive, Room 4A52 (MSC 2475), Bethesda, MD 20892. E-mail: wnarrow@nih.gov
U2  - PMID: 9856624.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107159459
T1  - Caregivers' experiences in making placement decisions...including commentary by Strang VR, Neufeld A, and Nolan M with author response
AU  - Penrod J
AU  - Dellasega C
Y1  - 1998/12//
N1  - Accession Number: 107159459. Language: English. Entry Date: 19990201. Revision Date: 20150820. Publication Type: Journal Article; commentary; research. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7905435. 
KW  - Relocation -- In Old Age
KW  - Caregiver Burden
KW  - Decision Making, Family
KW  - Long Term Care
KW  - Qualitative Studies
KW  - Grounded Theory
KW  - Interviews
KW  - Audiorecording
KW  - Field Notes
KW  - Convenience Sample
KW  - Constant Comparative Method
KW  - Thematic Analysis
KW  - Aged, Hospitalized
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 706
EP  - 732
JO  - Western Journal of Nursing Research
JF  - Western Journal of Nursing Research
JA  - WEST J NURS RES
VL  - 20
IS  - 6
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
AB  - Demographic trends indicate a growth in the older adult population, and in turn, are affecting the availability and use of health services. Although placement of an older adult charge into nursing home care is often described as a logical progression through the continuum of available services, informal caregivers often view placement as a last resort or as an indication of failure. This qualitative study used grounded theory methods to explore the experiences of caregivers actively involved in the process of placing an older adult in a long-term care facility upon discharge from acute care. Four themes (uncertainty, surrendering to the system, urgency, and validating) were interwoven throughout caregivers' perspectives of the conflictive decision to use nursing home care after hospitalization.
SN  - 0193-9459
AD  - National Institute on Aging Pre-Doctoral Fellow and Research Associate, Pennsylvania State University School of Nursing, 307 Health & Human Development East, University Park, PA 16802; E-mail: JLP198@PSU.EDU
U2  - PMID: 9842288.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107159459&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2005-07229-005
AN  - 2005-07229-005
AU  - Kitamura, Tishinori
AU  - Sugawara, M.
AU  - Toda, M. A.
AU  - Shima, S.
T1  - Childhood adversities and depression: I. Effects of early parental loss on the rearing behaviour of the remaining parent.
JF  - Archives of Women's Mental Health
JO  - Archives of Women's Mental Health
JA  - Arch Womens Ment Health
Y1  - 1998/12//
VL  - 1
IS  - 3
SP  - 131
EP  - 136
CY  - Germany
PB  - Springer
SN  - 1434-1816
SN  - 1435-1102
AD  - Kitamura, Tishinori, Department of Sociocultural Environmental Research, National Institute of Mental Health, 1-7-3 Konodai, Ichikawa, Chiba, Japan, 272
N1  - Accession Number: 2005-07229-005. Partial author list: First Author & Affiliation: Kitamura, Tishinori; National Institute of Mental Health, Chiba, Japan. Release Date: 20050718. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Major Depression; Parental Absence; Parenting Style; Parents. Classification: Affective Disorders (3211). Population: Human (10); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Parental Bonding Instrument DOI: 10.1037/t06510-000. Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 1998. 
AB  - Although early parental loss and perceived rearing have both been the target of intensive research, they have rarely been linked. This study examined the effects of parental loss on the perceived parenting of the remaining caregiver. The effect of early (before age 16) experience of the father's or mother's death or separation from them for 12 months or longer on the rearing behaviour of the remaining parent was studied retrospectively among 1,329 pregnant women. Women who had experienced either death of or separation from the father reported having received less care from the mother. However, experiences of loss of the mother did not show significant effects on the perceived rearing behaviour of the father. The number of siblings was correlated with reduced paternal and maternal care and with reduced maternal overprotection. Our hypothesis that early parental loss experience would have a negative influence on parental rearing behaviour was proved only for the effects of the paternal loss. Search for other determinants may be warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - childhood adversities
KW  - depression
KW  - parental loss
KW  - rearing behavior
KW  - parents
KW  - parenting style
KW  - 1998
KW  - Child Care
KW  - Major Depression
KW  - Parental Absence
KW  - Parenting Style
KW  - Parents
KW  - 1998
DO  - 10.1007/s007370050017
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07229-005&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41750-009
AN  - 2015-41750-009
AU  - Antoni, F. A.
AU  - Palkovits, M.
AU  - Simpson, J.
AU  - Smith, S. M.
AU  - Leitch, A. L.
AU  - Rosie, R.
AU  - Fink, G.
AU  - Paterson, J. M.
T1  - Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/12//
VL  - 18
IS  - 23
SP  - 9650
EP  - 9661
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Antoni, F. A., Medial Research Council Brain Metabolism Unit, Department of Neuroscience, University of Edinburgh, Edinburgh, Scotland, EH8 9JZ
N1  - Accession Number: 2015-41750-009. PMID: 9822726 Partial author list: First Author & Affiliation: Antoni, F. A.; Medial Research Council Brain Metabolism Unit, University of Edinburgh, Edinburgh, Scotland. Release Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Models; Calcium Ions; Forebrain; Adenylyl Cyclase. Minor Descriptor: Learning; Memory; Cell Signaling. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Dec, 1998. Publication History: Accepted Date: Sep 14, 1998; Revised Date: Sep 14, 1998; First Submitted Date: Aug 11, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - [Correction Notice: An Erratum for this article was reported in Vol 19(1) of The Journal of Neuroscience (see record [rid]2015-42399-052[/rid]). The printer incorrectly altered the title of the article. The title should read, 'Ca2+/ Calcineurin-Inhibited Adenylyl Cyclase Highly Abundant in Forebrain Regions Important for Learning and Memory.'] Activation of cAMP synthesis by intracellular Ca2+ is thought to be the main mode of cAMP generation in the brain. Accordingly, the Ca2+-activated adenylyl cyclases I and VIII are expressed prominently in forebrain neurons. The present study shows that the novel adenylyl cyclase type IX is inhibited by Ca2+ and that this effect is blocked selectively by inhibitors of calcineurin such as FK506 and cyclosporin A. Moreover, adenylyl cyclase IX is inhibited by the same range of intracellular free Ca2+ concentrations that stimulate adenylyl cyclase I. Adenylyl cyclase IX is expressed prominently in the forebrain. Substantial arrays of neurons positive for AC9 mRNA were found in the olfactory lobe, in limbic and neocortical areas, in the striatum, and in the cerebellar system. These data show that the initiation of the cAMP signal by adenylyl cyclase may be controlled by Ca2+/ calcineurin and thus provide evidence for a novel mode of tuning the cAMP signal by protein phosphorylation/dephosphorylation cascades. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cAMP
KW  - protein phosphatase
KW  - hippocampus
KW  - neocortex
KW  - striatum
KW  - adenylyl cyclase I
KW  - calcium
KW  - 1998
KW  - Animal Models
KW  - Calcium Ions
KW  - Forebrain
KW  - Adenylyl Cyclase
KW  - Learning
KW  - Memory
KW  - Cell Signaling
KW  - 1998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41750-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41750-026
AN  - 2015-41750-026
AU  - Drago, John
AU  - Padungchaichot, Poolpol
AU  - Wong, John Y. F.
AU  - Lawrence, Andrew J.
AU  - McManus, Julie F.
AU  - Sumarsono, Sony H.
AU  - Natoli, Anthony L.
AU  - Lakso, Merja
AU  - Wreford, Nigel
AU  - Westphal, Heiner
AU  - Kola, Ismail
AU  - Finkelstein, David I.
T1  - Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/12//
VL  - 18
IS  - 23
SP  - 9845
EP  - 9857
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Drago, John, Neurosciences Group, Department of Anatomy, Monash University, Wellington Road, Clayton, VIC, Australia, 3168
N1  - Accession Number: 2015-41750-026. PMID: 9822743 Partial author list: First Author & Affiliation: Drago, John; Neurosciences Group, Department of Anatomy, Monash University, Clayton, VIC, Australia. Release Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: McManus, Julie F. Major Descriptor: Basal Ganglia; Dopamine; Gene Expression; Neural Receptors. Minor Descriptor: Mice; Mutations. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Dec, 1998. Publication History: Accepted Date: Sep 22, 1998; Revised Date: Sep 21, 1998; First Submitted Date: Jun 8, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - [Correction Notice: An Erratum for this article was reported in Vol 19(2) of The Journal of Neuroscience (see record [rid]2015-42403-036[/rid]).In the original article, the figure citation on page 9847, left column, seventh line, should read (Fig. 3B).] Idiopathic Parkinson’s disease involves the loss of midbrain dopaminergic neurons, resulting in the presynaptic breakdown of dopaminergic transmission in the striatum. Huntington’s disease and some neurodegenerative diseases with Parkinsonian features have postsynaptic defects caused by striatal cell death. Mice were generated in which an attenuated form of the diphtheria toxin gene (tox-176) was expressed exclusively in D1 dopamine receptor (D1R)-positive cells with the aim of determining the effect of this mutation on development of the basal ganglia and on the locomotor phenotype. Transgenic mice expressing Cre, a site-specific DNA recombinase, were crossed with a second line in which a transcriptionally silenced tox-176 gene was inserted into the D1R gene locus by homologous recombination. Young doubly transgenic mutant mice expressing the tox-176 gene displayed bradykinesia, dystonia, and had falls caused by myoclonic jerks. The mutant brain had evidence of apoptosis and reactive gliosis and, consistent with the D1R expression pattern, the striatum was reduced in volume, and the Islands of Calleja were absent. In contrast, the cortex was of normal thickness. D1Rs were not detectable in mutants by in situ hybridization or ligand autoradiography, whereas D2 dopamine receptor (D2R) mRNA and protein was present in the striatum. In addition, substance P and dynorphin, neuropeptides known to be expressed in D1R-positive striatonigral projection neurons were not detectable. Enkephalin, a marker found in D2-positive striatopallidal projection neurons was expressed in the mutant brain. The mutant represents a novel neurodegenerative disease model with a dramatic extrapyramidal phenotype. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - D1 dopamine receptor
KW  - basal ganglia
KW  - Cre recombinase
KW  - gene targeting
KW  - striatum
KW  - Parkinson’s disease
KW  - 1998
KW  - Basal Ganglia
KW  - Dopamine
KW  - Gene Expression
KW  - Neural Receptors
KW  - Mice
KW  - Mutations
KW  - 1998
U1  - Sponsor: National Health and Medical Research Council, Australia. Recipients: McManus, Julie F.
U1  - Sponsor: Australian Commonwealth, Australia. Recipients: No recipient indicated
U1  - Sponsor: US Department of Veterans Affairs, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41750-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41847-007
AN  - 2015-41847-007
AU  - Sriram, Krishnan
AU  - Shankar, Susarla K.
AU  - Boyd, Michael R.
AU  - Ravindranath, Vijayalakshmi
T1  - Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/12//
VL  - 18
IS  - 24
SP  - 10287
EP  - 10296
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ravindranath, Vijayalakshmi, Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, India, 560 029
N1  - Accession Number: 2015-41847-007. PMID: 9852566 Partial author list: First Author & Affiliation: Sriram, Krishnan; Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India. Release Date: 20151102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amino Acids; N-Methyl-D-Aspartate; Mitochondria. Minor Descriptor: Ingestion; Mice; Neurodegeneration; Oxidative Stress. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 1998. Publication History: Accepted Date: Sep 28, 1998; Revised Date: Sep 21, 1998; First Submitted Date: May 26, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - Human ingestion of 'chickling peas' from the plant Lathyrus sativus, which contains an excitatory amino acid, L-BOAA (L-β-N-oxalylamino-L-alanine), leads to a progressive corticospinal neurodegenerative disorder, neurolathyrism. Exposure to L-BOAA, but not its optical enantiomer D-BOAA, causes mitochondrial dysfunction as evidenced by loss of complex I activity in vitro in male mouse brain slices and in vivo in selected regions of mouse CNS (lumbosacral cord and motor cortex). Loss of complex I activity in lumbosacral cord after L-BOAA administration to mice was accompanied by concurrent loss of glutathione. The inhibited complex I activity in mitochondria isolated from lumbosacral cord of animals treated with L-BOAA rebounded after incubation with the thiol-reducing agent dithiothreitol, indicating that oxidation of protein thiols to disulfides was responsible for enzyme inhibition. The inhibition of complex I could be abolished by pretreatment with antioxidant thiols such as glutathione ester and α-lipoic acid. Chronic treatment of male mice, but not female mice, with L-BOAA resulted in loss of complex I activity and vacuolation and dendritic swelling of neurons in the motor cortex and lumbar cord, paralleling the regionality of the aforementioned biochemical effects on CNS mitochondria. These results support the view that thiol oxidation and concomitant mitochondrial dysfunction (also implicated in other neurodegenerative disorders), occurring downstream of glutamate receptor activation by L-BOAA, are primary events leading to neurodegeneration. Maintenance of protein thiol homeostasis by thiol delivery agents could potentially offer protection against excitotoxic insults such as those seen with L-BOAA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - excitatory amino acids
KW  - mitochondrial electron transport
KW  - NADH ubiquinone-1 oxidoreductase (complex I)
KW  - brain
KW  - l-BOAA
KW  - oxidative stress
KW  - glutathione
KW  - protein thiol oxidation
KW  - 1998
KW  - Amino Acids
KW  - N-Methyl-D-Aspartate
KW  - Mitochondria
KW  - Ingestion
KW  - Mice
KW  - Neurodegeneration
KW  - Oxidative Stress
KW  - 1998
U1  - Sponsor: United States–India Fund for Cultural, Educational, and Scientific Cooperation. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41847-007&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-41847-015
AN  - 2015-41847-015
AU  - Harris-White, Marni E.
AU  - Chu, Teresa
AU  - Balverde, Zerlinde
AU  - Sigel, Jason J.
AU  - Flanders, Kathleen C.
AU  - Frautschy, Sally A.
T1  - Effects of transforming growth factor-β (isoforms 1–3) on amyloid-β deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1998/12//
VL  - 18
IS  - 24
SP  - 10366
EP  - 10374
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Harris-White, Marni E., University of California Los Angeles, 16111 Plummer Street (151), Sepulveda, CA, US, 91343
N1  - Accession Number: 2015-41847-015. PMID: 9852574 Partial author list: First Author & Affiliation: Harris-White, Marni E.; Department of Medicine, University of California Los Angeles, Sepulveda, CA, US. Release Date: 20151102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Harris-White, Marni E. Major Descriptor: Cytokines; Electroencephalography; Hippocampus; Pyramidal Neurons. Minor Descriptor: Inflammation; Rats; Neurodegeneration. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 1998. Publication History: Accepted Date: Sep 25, 1998; Revised Date: Sep 10, 1998; First Submitted Date: Apr 29, 1998. Copyright Statement: Society for Neuroscience. 1998. 
AB  - The transforming growth factor-beta (TGF-beta) family consists of three isoforms and is part of a larger family of cytokines regulating differentiation, development, and tissue repair. Previous work from our laboratory has shown that TGF-beta1 can increase amyloid-beta protein (Abeta) immunoreactive (Abetair) plaque-like deposits in rat brain. The aim of the current study was to evaluate all three isoforms of TGF-beta for their ability to affect the deposition and neurotoxicity of Abeta in an organotypic, hippocampal slice culture model of Abeta deposition. Slice cultures were treated with Abeta either with or without one of the TGF-beta isoforms. All three isoforms can increase Abeta accumulation (over Abeta treatment alone) within the slice culture, as determined by ELISA. However, there are striking differences in the pattern of Abetair among the three isoforms of TGF-beta. Isoforms 1 and 3 produced a cellular pattern of Abeta staining that colocalizes with GS lectin staining (microglia). TGF-beta2 produces dramatic Abeta staining of pyramidal neurons in layers CA1-CA2. In addition to cellular Abeta staining, plaque-like deposits are increased by all of the TGF-betas. Although no gross toxicity was observed, morphological neurodegenerative changes were seen in the CA1 region when the slices were treated with Abeta plus TGF-beta2. Our results demonstrate important functional differences among the TGF-beta isoforms in their ability to alter the cellular distribution and degradation of Abeta. These changes may be relevant to the pathology of Alzheimer's disease (AD). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - Alzheimer’s disease
KW  - aging
KW  - trauma
KW  - injury
KW  - growth factor
KW  - amyloid
KW  - 1998
KW  - Cytokines
KW  - Electroencephalography
KW  - Hippocampus
KW  - Pyramidal Neurons
KW  - Inflammation
KW  - Rats
KW  - Neurodegeneration
KW  - 1998
U1  - Sponsor: French Foundation, France. Other Details: Fellowship. Recipients: No recipient indicated
U1  - Sponsor: Los Angeles Alzheimer’s Association, US. Other Details: Turken Fellowship. Recipients: No recipient indicated
U1  - Sponsor: University of California Los Angeles, Alzheimer’s Disease Center, US. Other Details: Pilot. Recipients: Harris-White, Marni E.
U1  - Sponsor: Sponsor name not included, AG10685. Recipients: Frautschy, Sally A.
U1  - Sponsor: US Department of Veterans Affairs, US. Other Details: Merit Award. Recipients: Frautschy, Sally A.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-41847-015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Quinn, Thomas C
T1  - Molecular variants of HIV-1 and their impact on vaccine development.
JO  - International Journal of STD & AIDS
JF  - International Journal of STD & AIDS
Y1  - 1998/12/02/Dec1998 Supplement 1
VL  - 9
M3  - Article
SP  - 2
EP  - 2
PB  - Sage Publications, Ltd.
SN  - 09564624
AB  - The article presents the molecular variants of HIV-1 including the main (M) group and outlier (O) group. HIV-1 M group have ten subtypes and comprises over 95% of all HIV infections while O group were not classified and have limited distribution. The impact of diverse molecular variation in the HIV genome on the viral evolution and development of AIDS vaccine are discussed. Distinctive features of HIV variants, causes of HIV diversity and recommendations on vaccine development are enumerated.
KW  - AIDS (Disease)
KW  - VACCINATION
KW  - Virus diseases
KW  - Viral variation
KW  - Viral genetics
KW  - Preventive medicine
N1  - Accession Number: 22202311; Quinn, Thomas C 1,2; Affiliations: 1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Maryland; 2: Division of Infectious Diseases, Ross Research Building, Johns Hopkins University, USA; Issue Info: Dec1998 Supplement 1, Vol. 9, p2; Thesaurus Term: AIDS (Disease); Thesaurus Term: VACCINATION; Thesaurus Term: Virus diseases; Subject Term: Viral variation; Subject Term: Viral genetics; Subject Term: Preventive medicine; Number of Pages: 1p; Document Type: Article
L3  - 10.1258/0956462981921567
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22202311&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 105846819
T1  - Effects of two putative endogenous digitalis-like factors, marinobufagenin and ouabain, on the Na+, K+-pump in human mesenteric arteries.
AU  - Bagrov AY
AU  - Fedorova OV
Y1  - 1998/12/02/1998 Supplement 12
N1  - Accession Number: 105846819. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 1998 Supplement 12. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8306882. 
KW  - Cardiac Glycosides -- Pharmacodynamics
KW  - Mesenteric Arteries
KW  - Mesenteric Arteries -- Drug Effects
KW  - Steroids -- Pharmacodynamics
KW  - Animals
KW  - Cardiac Glycosides -- Metabolism
KW  - Digitalis Glycosides -- Metabolism
KW  - Digitalis Glycosides -- Pharmacodynamics
KW  - Enzyme Inhibitors -- Metabolism
KW  - Enzyme Inhibitors -- Pharmacodynamics
KW  - Isoenzymes
KW  - Isoenzymes -- Metabolism
KW  - Male
KW  - Mesenteric Arteries -- Physiology
KW  - Middle Age
KW  - Molecular Structure
KW  - Rats
KW  - Steroids -- Metabolism
KW  - Vasoconstriction -- Drug Effects
SP  - 1953
EP  - 1958
JO  - Journal of Hypertension
JF  - Journal of Hypertension
JA  - J HYPERTENS
VL  - 16
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - OBJECTIVES: Recently, in rat aortae, two putative digitalis-like factors, marinobufagenin and ouabain, were shown to interact with alpha-1 (sarcolemma) and alpha-3 (nerve endings) subunits of the sodium pump, respectively, and elicit vasoconstriction via inhibition of the Na+,K+-pump in vascular smooth muscle or norepinephrine release. The purpose of the present study was to investigate the effects of ouabain and marinobufagenin on vascular tone, activity of Na+,K+-pump, and the expression of isoforms of the Na+,K+-ATPase alpha-subunit in human mesenteric arteries. DESIGN AND METHODS: Arteries were obtained from male patients undergoing surgery due to intestinal adenocarcinoma. Vasoconstrictor effects of both inhibitors were studied in isolated vascular rings. Na+,K+-pump activity was measured using the 86Rb technique. Membrane fractions of sarcolemma and nerve endings plasmalemma were prepared via differential centrifugation of membranes in a sucrose density gradient Specific antibodies to the alpha-1 and alpha-3 subunits of Na+,K+-ATPase were used to detect alpha-1 and alpha-3 isoforms in the membrane fractions by Western blotting. RESULTS: Marinobufagenin (EC50 = 88+/-15 nmoles/l) and ouabain (EC50 = 320+/-50 nmoles/l) elicited vasoconstriction in mesenteric artery rings. At a concentration of 1 nmol/l, both compounds stimulated the Na+,K+-pump, but inhibited its activity at 10-1000 nmoles/l. No stimulation of the Na+,K+-pump was observed in the presence of 5 micromol/l phentolamine; rather 1 nmol/l of marinobufagenin and ouabain inhibited the Na+,K+-pump by 30% and 13%, respectively. The alpha-1 polyclonal antibody detected alpha-1 isoform in membrane fractions from both sarcolemma and nerve endings. A monoclonal alpha-1 antibody detected the material in sarcolemmal membranes only. The alpha-3 isoform was detected in both membrane fractions by both antibodies, but staining for alpha-3 was more pronounced in the nerve endings. CONCLUSIONS: These results demonstrate that, in physiologically 'realistic' concentrations, marinobufagenin and ouabain can significantly affect the Na+,K+-pump in human mesenteric artery, and illustrate the importance of interaction of digitalis-like Na+,K+-pump inhibitors with the Na+,K+-ATPase localized to the intravascular adrenergic terminals. Present observations are in accord with the previous data suggesting that marinobufagenin and ouabain display greater affinity to alpha-1 and alpha-3 isoforms of the Na+,K+-pump, respectively, and support the view that the differential responsiveness to endogenous digitalis-like inhibitors is one of the features of alpha-isoforms of Na+,K+-ATPase.
SN  - 0263-6352
AD  - Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA.
U2  - PMID: 9886882.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105846819&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sheu, Yngshiuh
T1  - Drug abuse and acquired immune deficiency syndrome.
JO  - Psychiatry & Clinical Neurosciences
JF  - Psychiatry & Clinical Neurosciences
Y1  - 1998/12/02/Dec98 Supplement
VL  - 52
M3  - Article
SP  - S167
EP  - S169
PB  - Wiley-Blackwell
SN  - 13231316
AB  - Acquired immune deficiency syndrome (AIDS) is a modern plague. The first sign of the disease was the appearance of Pneumocystis carinii and Kaposi's sarcoma among young homosexual patients. The virus transmission is from an infected individual to a susceptible host through blood-related, sexual, and perinatal routes. Exchange of body fluid occurs when sharing syringes, drugs, and drug paraphernalia. Although the largest number of people infected with human immunodeficiency virus (HIV) is in subSaharan Africa, the most rapid growth of HIV infection during the 1990s was seen in South-East Asia. Asia showed a steep increase from 1992. Given the experiences in Thailand, India and China, a similar spread of AIDS in other parts of Asia is possible. The risk behaviors that enable the spread of HIV are present in all Pacific Asian countries. Risk behaviors are considered to be the injection of illicit drugs, male patronage of prostitutes, high rates of sexually transmitted diseases, and low condom use. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS (Disease)
KW  - PNEUMOCYSTIS carinii
KW  - KAPOSI'S sarcoma
KW  - DRUG paraphernalia
KW  - HIV (Viruses)
KW  - acquired immune deficiency syndrome
KW  - drug abuse
KW  - human immunodeficiency virus
N1  - Accession Number: 26747219; Sheu, Yngshiuh 1; Affiliation:  1: Medical Affairs, Division of Clinical Research and Services, National Institute on Drug Abuse, Rockville, Maryland, USA.; Source Info: Dec98 Supplement, Vol. 52, pS167; Subject Term: AIDS (Disease); Subject Term: PNEUMOCYSTIS carinii; Subject Term: KAPOSI'S sarcoma; Subject Term: DRUG paraphernalia; Subject Term: HIV (Viruses); Author-Supplied Keyword: acquired immune deficiency syndrome; Author-Supplied Keyword: drug abuse; Author-Supplied Keyword: human immunodeficiency virus; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kitamura, Toshinori
T1  - Psychiatric epidemiology in Japan: Towards psychological understanding of the etiology of minor psychiatric disorders.
JO  - Psychiatry & Clinical Neurosciences
JF  - Psychiatry & Clinical Neurosciences
Y1  - 1998/12/02/Dec98 Supplement
VL  - 52
M3  - Article
SP  - S275
EP  - S277
PB  - Wiley-Blackwell
SN  - 13231316
AB  - Epidemiological studies of psychiatric disorders using structured interviews and operational diagnostic criteria in a community population are rare in Japan. In our community study with mainly middle-aged people (Kofu Study), the lifetime prevalence of Major Depressive Episode was 19%. The prevalence was about twice as high in women as in men. The prevalence of Major Depressive Episode showed a tendency to increase as the subjects became younger. No sex difference in the lifetime prevalence of Major Depressive Episode was observed among an adolescent population (Gotemba Study), due to the equally high prevalence of this disorder among male adolescents. The figures were 24% for men and 23% for women. In a follow-up study of pregnant women (Kawasaki Study), risk factors of depression during pregnancy and after childbirth are different and, in some instances, reversed. Therefore, we speculate that the combination of psychological risk factors of the onset of depression may differ from one situation to another. Specificity of the combination of risk factors may be more important than single risk factors in the etiology of mild-form depression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PATHOLOGICAL psychology
KW  - MENTAL depression
KW  - PREGNANT women
KW  - PRENATAL care
KW  - SOCIAL psychiatry
KW  - childbirth
KW  - depression
KW  - epidemiology
KW  - pregnancy
KW  - psychiatric disorders
N1  - Accession Number: 26747250; Kitamura, Toshinori 1; Affiliation:  1: Department of Sociocultural Environmental Research, National Institute of Mental Health, NCNP, Chiba, Japan.; Source Info: Dec98 Supplement, Vol. 52, pS275; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL depression; Subject Term: PREGNANT women; Subject Term: PRENATAL care; Subject Term: SOCIAL psychiatry; Author-Supplied Keyword: childbirth; Author-Supplied Keyword: depression; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: pregnancy; Author-Supplied Keyword: psychiatric disorders; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Otsuka, Toshio
T1  - Current status of and challenges for dementia in Japan.
JO  - Psychiatry & Clinical Neurosciences
JF  - Psychiatry & Clinical Neurosciences
Y1  - 1998/12/02/Dec98 Supplement
VL  - 52
M3  - Article
SP  - S300
EP  - S302
PB  - Wiley-Blackwell
SN  - 13231316
AB  - With an increase in the elderly population in Japan, the number of elderly with dementia increases each year. There were about 1.26 million elderly people with dementia in 1995. Dementia is untreatable, requiring protracted care. Enhancing and improving the social services for the demented elderly are strongly recommended. The available social services for the elderly with dementia in Japan are measures for health and institutional care. In the former, there are consultations, guidance services and welfare services (home help services, day services, short stay services). The latter mainly consists of mental hospitals, hospitals for the elderly, health facilities for the elderly and special nursing homes for the elderly. As future challenges to improve measures for the demented elderly, the following measures must be offered to demented elderly: (i) urgent, quantitative improvements in social services; (ii) establishing a comprehensive service system in the community; (iii) clarifying the concept of role sharing and closer cooperation among hospitals and institutions; (iv) training human resources in the fields of health medical care and welfare to give expertise and skill; (v) improvement of the system for dementia research; and (vi) securing and training volunteers for home care. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DEMENTIA
KW  - NEUROBEHAVIORAL disorders
KW  - PSYCHOSES
KW  - SOCIAL services
KW  - PSYCHIATRIC hospitals
KW  - dementia
KW  - home care
KW  - institutional care
N1  - Accession Number: 26747258; Otsuka, Toshio 1; Affiliation:  1: National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan.; Source Info: Dec98 Supplement, Vol. 52, pS300; Subject Term: DEMENTIA; Subject Term: NEUROBEHAVIORAL disorders; Subject Term: PSYCHOSES; Subject Term: SOCIAL services; Subject Term: PSYCHIATRIC hospitals; Author-Supplied Keyword: dementia; Author-Supplied Keyword: home care; Author-Supplied Keyword: institutional care; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Thompson, Mark W.
AU  - Miller, Jay
AU  - Maurizi, Michael R.
AU  - Kempner, Ellis
T1  - Importance of heptameric ring integrity for activity of Escherichia coli ClpP.
JO  - European Journal of Biochemistry
JF  - European Journal of Biochemistry
Y1  - 1998/12/15/Dec98 Part 2
VL  - 258
IS  - 3
M3  - Article
SP  - 923
EP  - 928
PB  - Wiley-Blackwell
SN  - 00142956
AB  - Radiation target analysis has been used to identify the minimal functional unit for expression of activity of ClpP, the proteolytic component of the ATP-dependent ClpAP protease. Radiation target sizes determined for small peptide hydrolysis, for ClpA-activated and nucleotide-activated oligopeptide cleavage, and for ClpA-activated ATP-dependent protein degradation were 154, 118, and 160 kDa, respectively. Thus, the hydrolytic activity of ClpP, subunit Mr 21 500, is dependent on the native oligomeric structure. The quaternary structure of ClpP determined by electron microscopy and hydrodynamic studies consists of two face-to-face seven-membered rings. The radiation target sizes are consistent with a requirement for conformational integrity of an entire ring for expression of hydrolytic activity. Radiation damage led to disruption of inter-ring contacts, giving rise to isolated rings of ClpP. Thus, contacts between rings of ClpP are less stable and more easily disrupted than contacts between subunits within the rings. Our data suggest that cooperative interactions between subunits within the ClpP rings are important for maintaining the active conformation of the proteolytic active site. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ESCHERICHIA coli
KW  - ADENOSINE triphosphate
KW  - ATP-dependent protease
KW  - CLPP
KW  - radiation target analysis.
N1  - Accession Number: 5276735; Thompson, Mark W. 1 Miller, Jay 2 Maurizi, Michael R. 3 Kempner, Ellis 2; Affiliation:  1: Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA  2: Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA  3: Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA; Source Info: Dec98 Part 2, Vol. 258 Issue 3, p923; Subject Term: ESCHERICHIA coli; Subject Term: ADENOSINE triphosphate; Author-Supplied Keyword: ATP-dependent protease; Author-Supplied Keyword: CLPP; Author-Supplied Keyword: radiation target analysis.; Number of Pages: 6p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3  - 10.1046/j.1432-1327.1998.2580923.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Carroll, Miles W.
AU  - Overwijk, Willem W.
AU  - Surman, Deborah R.
AU  - Tsung, Kangla
AU  - Moss, Bernard
AU  - Restifo, Nicholas P.
AU  - Carroll, M W
AU  - Overwijk, W W
AU  - Surman, D R
AU  - Tsung, K
AU  - Moss, B
AU  - Restifo, N P
T1  - Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen.
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
Y1  - 1998/12/16/
VL  - 90
IS  - 24
M3  - journal article
SP  - 1881
EP  - 1887
SN  - 00278874
AB  - <bold>Background: </bold>Construction of recombinant viruses that can serve as vaccines for the treatment of experimental murine tumors has recently been achieved. The cooperative effects of immune system modulators, including cytokines such as interleukin 12 (IL-12) and costimulatory molecules such as B7-1, may be necessary for activation of cytotoxic T lymphocytes. Thus, we have explored the feasibility and the efficacy of inclusion of these immunomodulatory molecules in recombinant virus vaccines in an experimental antitumor model in mice that uses Escherichia coli beta-galactosidase as a target antigen.<bold>Methods: </bold>We developed a "cassette" system in which three loci of the vaccinia virus genome were used for homologous recombination. A variety of recombinant vaccinia viruses were constructed, including one virus, vB7/beta/IL-12, that contains the following five transgenes: murine B7-1, murine IL-12 subunit p35, murine IL-12 subunit p40, E. coli lacZ (encodes beta-galactosidase, the model antigen), and E. coli gpt (xanthine-guanine phosphoribosyltransferase, a selection gene). The effects of the recombinant viruses on lung metastases and survival were tested in animals that had been given an intravenous injection of beta-galactosidase-expressing murine colon carcinoma cells 3 days before they received the recombinant virus by intravenous inoculation.<bold>Results: </bold>Expression of functional B7-1 and IL-12 by virally infected cells was demonstrated in vitro. Lung tumor nodules (i.e., metastases) were reduced in mice by more than 95% after treatment with the virus vB7/beta/IL-12; a further reduction in lung tumor nodules was observed when exogenous IL-12 was also given. Greatest survival of tumor-bearing mice was observed in those treated with viruses encoding beta-galactosidase and B7-1 plus exogenous IL-12.<bold>Conclusion: </bold>This study shows the feasibility of constructing vaccinia viruses that express tumor antigens and multiple immune cofactors to create unique immunologic microenvironments that can modulate immune responses to cancer. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE system
KW  - RECOMBINANT viruses
KW  - ESCHERICHIA coli
KW  - THERAPEUTIC use
N1  - Accession Number: 1402796; Carroll, Miles W. Overwijk, Willem W. Surman, Deborah R. Tsung, Kangla Moss, Bernard Restifo, Nicholas P. Carroll, M W 1 Overwijk, W W Surman, D R Tsung, K Moss, B Restifo, N P; Affiliation:  1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-1502, USA; Source Info: 12/16/98, Vol. 90 Issue 24, p1881; Subject Term: IMMUNE system; Subject Term: RECOMBINANT viruses; Subject Term: ESCHERICHIA coli; Subject Term: THERAPEUTIC use; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Graphs; Document Type: journal article; Full Text Word Count: 6697
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rosenberg, Steven A.
AU  - Zhai, Yifan
AU  - Yang, James C.
AU  - Schwartzentruber, Douglas J.
AU  - Hwu, Patrick
AU  - Marincola, Francesco M.
AU  - Topalian, Suzanne L.
AU  - Restifo, Nicholas P.
AU  - Seipp, Claudia A.
AU  - Einhorn, Jan H.
AU  - Roberts, Bruce
AU  - White, Donald E.
AU  - Rosenberg, S A
AU  - Zhai, Y
AU  - Yang, J C
AU  - Schwartzentruber, D J
AU  - Hwu, P
AU  - Marincola, F M
AU  - Topalian, S L
AU  - Restifo, N P
T1  - Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens.
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
Y1  - 1998/12/16/
VL  - 90
IS  - 24
M3  - journal article
SP  - 1894
EP  - 1900
SN  - 00278874
AB  - <bold>Background: </bold>The characterization of the genes encoding melanoma-associated antigens MART-1 or gp100, recognized by T cells, has opened new possibilities for the development of immunization strategies for patients with metastatic melanoma. With the use of recombinant adenoviruses expressing either MART-1 or gp100 to immunize patients with metastatic melanoma, we evaluated the safety, immunologic, and potential therapeutic aspects of these immunizations.<bold>Methods: </bold>In phase I studies, 54 patients received escalating doses (between 10(7) and 10(11) plaque-forming units) of recombinant adenovirus encoding either MART-1 or gp100 melanoma antigen administered either alone or followed by the administration of interleukin 2 (IL-2). The immunologic impact of these immunizations on the development of cellular and antibody reactivity was assayed.<bold>Results: </bold>Recombinant adenoviruses expressing MART-1 or gp100 were safely administered. One of 16 patients with metastatic melanoma receiving the recombinant adenovirus MART-1 alone experienced a complete response. Other patients achieved objective responses, but they had received IL-2 along with an adenovirus, and their responses could be attributed to the cytokine. Immunologic assays showed no consistent immunization to the MART-1 or gp100 transgenes expressed by the recombinant adenoviruses. High levels of neutralizing antibody were found in the pretreatment sera of the patients.<bold>Conclusions: </bold>High doses of recombinant adenoviruses could be safely administered to cancer patients. High levels of neutralizing antibody present in patients' sera prior to treatment may have impaired the ability of these viruses to immunize patients against melanoma antigens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNIZATION
KW  - RESEARCH
KW  - ADENOVIRUS diseases
KW  - MELANOMA
KW  - TREATMENT
N1  - Accession Number: 1402798; Rosenberg, Steven A. Zhai, Yifan Yang, James C. Schwartzentruber, Douglas J. Hwu, Patrick Marincola, Francesco M. Topalian, Suzanne L. Restifo, Nicholas P. Seipp, Claudia A. Einhorn, Jan H. Roberts, Bruce White, Donald E. Rosenberg, S A 1 Zhai, Y Yang, J C Schwartzentruber, D J Hwu, P Marincola, F M Topalian, S L Restifo, N P; Affiliation:  1: Surgery Branch, National Cancer Institute, Bethesda, MD, USA; Source Info: 12/16/98, Vol. 90 Issue 24, p1894; Subject Term: IMMUNIZATION; Subject Term: RESEARCH; Subject Term: ADENOVIRUS diseases; Subject Term: MELANOMA; Subject Term: TREATMENT; Number of Pages: 7p; Illustrations: 2 Graphs; Document Type: journal article; Full Text Word Count: 6526
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1402796
T1  - Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen.
AU  - Carroll, Miles W.
AU  - Overwijk, Willem W.
AU  - Surman, Deborah R.
AU  - Tsung, Kangla
AU  - Moss, Bernard
AU  - Restifo, Nicholas P.
AU  - Carroll, M W
AU  - Overwijk, W W
AU  - Surman, D R
AU  - Tsung, K
AU  - Moss, B
AU  - Restifo, N P
Y1  - 1998/12/16/
N1  - Accession Number: 1402796. Language: English. Entry Date: 19990301. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Functional Living Index: Cancer (FLIC) (Schipper et al). Grant Information: Z01 BC010763-01//Intramural NIH HHS/United States. NLM UID: 7503089. 
KW  - Neoplasms -- Therapy
KW  - Viruses
KW  - Antigens, Surface
KW  - Antigens, Tumor
KW  - Interleukins
KW  - Cancer Vaccines
KW  - Mice
KW  - Antigens, Surface -- Immunology
KW  - Cancer Vaccines -- Therapeutic Use
KW  - Glycoside Hydrolases -- Immunology
KW  - Viruses -- Immunology
KW  - Interleukins -- Immunology
KW  - Female
KW  - Glycoside Hydrolases
KW  - Escherichia Coli
KW  - Lung Neoplasms -- Therapy
KW  - Lung Neoplasms
KW  - Animals
KW  - Genome
KW  - Tumor Cells, Cultured
KW  - Transferases
KW  - Pilot Studies
KW  - Blotting, Western
KW  - Flow Cytometry
KW  - Clinical Assessment Tools
SP  - 1881
EP  - 1887
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 90
IS  - 24
PB  - Oxford University Press / USA
AB  - Background: Construction of recombinant viruses that can serve as vaccines for the treatment of experimental murine tumors has recently been achieved. The cooperative effects of immune system modulators, including cytokines such as interleukin 12 (IL-12) and costimulatory molecules such as B7-1, may be necessary for activation of cytotoxic T lymphocytes. Thus, we have explored the feasibility and the efficacy of inclusion of these immunomodulatory molecules in recombinant virus vaccines in an experimental antitumor model in mice that uses Escherichia coli beta-galactosidase as a target antigen.Methods: We developed a "cassette" system in which three loci of the vaccinia virus genome were used for homologous recombination. A variety of recombinant vaccinia viruses were constructed, including one virus, vB7/beta/IL-12, that contains the following five transgenes: murine B7-1, murine IL-12 subunit p35, murine IL-12 subunit p40, E. coli lacZ (encodes beta-galactosidase, the model antigen), and E. coli gpt (xanthine-guanine phosphoribosyltransferase, a selection gene). The effects of the recombinant viruses on lung metastases and survival were tested in animals that had been given an intravenous injection of beta-galactosidase-expressing murine colon carcinoma cells 3 days before they received the recombinant virus by intravenous inoculation.Results: Expression of functional B7-1 and IL-12 by virally infected cells was demonstrated in vitro. Lung tumor nodules (i.e., metastases) were reduced in mice by more than 95% after treatment with the virus vB7/beta/IL-12; a further reduction in lung tumor nodules was observed when exogenous IL-12 was also given. Greatest survival of tumor-bearing mice was observed in those treated with viruses encoding beta-galactosidase and B7-1 plus exogenous IL-12.Conclusion: This study shows the feasibility of constructing vaccinia viruses that express tumor antigens and multiple immune cofactors to create unique immunologic microenvironments that can modulate immune responses to cancer.
SN  - 0027-8874
AD  - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-1502, USA
U2  - PMID: 9862625.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107174474
T1  - Chronically depressed mood and cancer risk in older persons.
AU  - Penninx BWJ
AU  - Guralnik JM
AU  - Pahor M
AU  - Ferrucci L
AU  - Cerhan JR
AU  - Wallace RB
AU  - Havlik RJ
Y1  - 1998/12/16/
N1  - Accession Number: 107174474. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: Public Health Service (PHS) contracts N01AG0215, N01AG02106, and N01AG02107 from the National Institute on Aging, National Institutes of Health (NIH), Department of Health and Human Services. B.W.J.H. Penninx was supported by the Dutch Niels Stensen Stichting, and J.R. Cerhan was supported by PHS award K07CA64220 from the National Cancer Institute, NIH. NLM UID: 7503089. 
KW  - Depression -- Complications
KW  - Neoplasms
KW  - Chronic Disease
KW  - Neoplasms -- Psychosocial Factors
KW  - Neoplasms -- Epidemiology
KW  - Center for Epidemiological Studies Depression Scale
KW  - Psychological Tests
KW  - Prospective Studies
KW  - Kappa Statistic
KW  - Chi Square Test
KW  - T-Tests
KW  - Mann-Whitney U Test
KW  - Cox Proportional Hazards Model
KW  - Data Analysis Software
KW  - Kaplan-Meier Estimator
KW  - Odds Ratio
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 1888
EP  - 1893
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 90
IS  - 24
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Epidemiology, National Institute on Aging, Bethesda, MD
U2  - PMID: 9862626.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 1402798
T1  - Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens.
AU  - Rosenberg, Steven A.
AU  - Zhai, Yifan
AU  - Yang, James C.
AU  - Schwartzentruber, Douglas J.
AU  - Hwu, Patrick
AU  - Marincola, Francesco M.
AU  - Topalian, Suzanne L.
AU  - Restifo, Nicholas P.
AU  - Seipp, Claudia A.
AU  - Einhorn, Jan H.
AU  - Roberts, Bruce
AU  - White, Donald E.
AU  - Rosenberg, S A
AU  - Zhai, Y
AU  - Yang, J C
AU  - Schwartzentruber, D J
AU  - Hwu, P
AU  - Marincola, F M
AU  - Topalian, S L
AU  - Restifo, N P
Y1  - 1998/12/16/
N1  - Accession Number: 1402798. Language: English. Entry Date: 19990301. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Impact of Events Scale (IES). Grant Information: Z01 BC010763-01//Intramural NIH HHS/United States. NLM UID: 7503089. 
KW  - Viruses
KW  - Cancer Vaccines
KW  - Proteins
KW  - Skin Neoplasms -- Immunology
KW  - Skin Neoplasms -- Prevention and Control
KW  - Antigens, Tumor
KW  - Membrane Glycoproteins
KW  - Melanoma -- Immunology
KW  - Melanoma -- Prevention and Control
KW  - Tumor Cells, Cultured
KW  - Proteins -- Immunology
KW  - Cancer Vaccines -- Immunology
KW  - Protocols
KW  - Antibodies, Viral -- Blood
KW  - Cancer Vaccines -- Administration and Dosage
KW  - Membrane Glycoproteins -- Immunology
KW  - Skin Neoplasms -- Pathology
KW  - Antigens, Tumor -- Immunology
KW  - Membrane Proteins
KW  - Treatment Outcomes
KW  - Human
KW  - Melanoma
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Impact of Events Scale
SP  - 1894
EP  - 1900
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 90
IS  - 24
PB  - Oxford University Press / USA
AB  - Background: The characterization of the genes encoding melanoma-associated antigens MART-1 or gp100, recognized by T cells, has opened new possibilities for the development of immunization strategies for patients with metastatic melanoma. With the use of recombinant adenoviruses expressing either MART-1 or gp100 to immunize patients with metastatic melanoma, we evaluated the safety, immunologic, and potential therapeutic aspects of these immunizations.Methods: In phase I studies, 54 patients received escalating doses (between 10(7) and 10(11) plaque-forming units) of recombinant adenovirus encoding either MART-1 or gp100 melanoma antigen administered either alone or followed by the administration of interleukin 2 (IL-2). The immunologic impact of these immunizations on the development of cellular and antibody reactivity was assayed.Results: Recombinant adenoviruses expressing MART-1 or gp100 were safely administered. One of 16 patients with metastatic melanoma receiving the recombinant adenovirus MART-1 alone experienced a complete response. Other patients achieved objective responses, but they had received IL-2 along with an adenovirus, and their responses could be attributed to the cytokine. Immunologic assays showed no consistent immunization to the MART-1 or gp100 transgenes expressed by the recombinant adenoviruses. High levels of neutralizing antibody were found in the pretreatment sera of the patients.Conclusions: High doses of recombinant adenoviruses could be safely administered to cancer patients. High levels of neutralizing antibody present in patients' sera prior to treatment may have impaired the ability of these viruses to immunize patients against melanoma antigens.
SN  - 0027-8874
AD  - Surgery Branch, National Cancer Institute, Bethesda, MD, USA
U2  - PMID: 9862627.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=1402798&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Agarwala, Richa
AU  - Bafna, Vineet
AU  - Farach, Martin
AU  - Paterson, Mike
AU  - Thorup, Mikkel
T1  - ON THE APPROXIMABILITY OF NUMERICAL TAXONOMY (FITTING DISTANCES BY TREE METRICS).
JO  - SIAM Journal on Computing
JF  - SIAM Journal on Computing
Y1  - 1998/12/31/
VL  - 28
IS  - 3
M3  - Article
SP  - 1073
PB  - Society for Industrial & Applied Mathematics
SN  - 00975397
AB  - We consider the problem of fitting an n × n distance matrix D by a tree metric T. Let ∊ be the distance to the closest tree metric under the L[SUB∞] norm; that is, ∊ = min[SUBT] {‖ T -D ‖ ∞}. First we present an O(n[SUP2]) algorithm for finding a tree metric T such that ‖T -D‖ ∞ ≤ 3∊. Second we show that it is NP-hard to find a tree metric T such that ‖T -D ‖ < &frac98;∊ . This paper presents the first algorithm for this problem with a performance guarantee. [ABSTRACT FROM AUTHOR]
AB  - Copyright of SIAM Journal on Computing is the property of Society for Industrial & Applied Mathematics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NUMERICAL taxonomy
KW  - ALGORITHMS
KW  - TREE graphs
KW  - SOFTWARE measurement
KW  - approximation algorithm
KW  - taxonomy
KW  - tree metric
N1  - Accession Number: 10699527; Agarwala, Richa 1,2; Email Address: richa@helix.nih.gov Bafna, Vineet 1; Email Address: bafna@dimacs.rutgers.edu Farach, Martin 3; Email Address: farach@cs.rutgers.edu Paterson, Mike 4; Email Address: msp@dcs.warwick.ac.uk Thorup, Mikkel 5; Email Address: mthorup@diku.dk; Affiliation:  1: DIMACS, Rutgers University, Piscataway.  2: National Human Genome Research Institute/National Institutes of Health.  3: Department of Computer Science, Rutgers University, Piscataway.  4: Department of Computer Science, University of Warwick, Coventry.  5: Department of Computer Science, University of Copenhagen, Universitetsparken.; Source Info: 1998, Vol. 28 Issue 3, p1073; Subject Term: NUMERICAL taxonomy; Subject Term: ALGORITHMS; Subject Term: TREE graphs; Subject Term: SOFTWARE measurement; Author-Supplied Keyword: approximation algorithm; Author-Supplied Keyword: taxonomy; Author-Supplied Keyword: tree metric; Number of Pages: 13p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10699527&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - Gen
ID  - 9999-18545-000
AN  - 9999-18545-000
AU  - Simons-Morton, Bruce
AU  - Haynie, Denise L.
AU  - Crump, Aria Davis
AU  - Saylor, Keith E.
AU  - Eitel, Patricia
AU  - Yu, Kai
T1  - Predictors of Alcohol Use Questionnaire
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1999///
AD  - Simons-Morton, Bruce, National Institutes of Health, Prevention Research Branch, DESPR, Building 6100, Room 7B05, 9000 Rockville Pike, Bethesda, Maryland, United States, 20892-7510
AV  - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1  - Accession Number: 9999-18545-000. Partial author list: First Author & Affiliation: Simons-Morton, Bruce; National Institutes of Health, Bethesda, Maryland, United States. Release Date: 20130311. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Language: English. Constructs: Alcohol Use Predictors; Risk Factors; Classification: Addiction, Gambling, and Substance Abuse/Use (5000). Population: Human (10); Male (30); Female (40). 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Predictors of Alcohol Use Questionnaire is to measure variables which could be possible predictors of alcohol use.
AB  - Description: The Predictors of Alcohol Use Questionnaire (Simons-Morton, 1999) was developed to measure variables which could be possible predictors of alcohol use. This questionnaire was designed for the purposes of a study examining expectancies and other psychosocial factors associated with alcohol use among early adolescent boys and girls. Students in all seven middle schools in a suburban Maryland school district were recruited for the study. The questionnaire consisted of items concerning a variety of psychosocial, school, and parent variables. For scales measuring perceptions, missing values for subjects who completed at least three-fifths of the scale items were imputed, based on the item mean for students of the same grade and sex (Kessler, Little, & Groves, 1995). Indices measuring depressive symptoms and self-control were developed by Weinberger (1991) and the index measuring school climate was developed by Pyper, Freiberg, Ginsburg, and Spuck (1987). Other indices measuring psychosocial, school, and parent variables were developed for this study. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW  - Alcohol Use
KW  - Family Structure
KW  - Internal Consistency
KW  - Parenting
KW  - Predictors of Alcohol Use Questionnaire
KW  - Psychosocial Factors
KW  - School Adjustment
KW  - School Climate
U5  - Predictors of Alcohol Use Questionnaire [Test Development]Expectancies and other psychosocial factors associated with alcohol use among early adolescent boys and girls. (AN: 1999-13811-007 from PsycINFO) Simons-Morton, Bruce; Haynie, Denise L.; Crump, Aria Davis; Saylor, Keith E.; Eitel, Patricia; Yu, Kai; Mar-Apr, 1999. Source: Addictive Behaviors. 24(2), Elsevier Science, Netherlands; Mar-Apr, 1999; Administration: Paper Population: Human; Male; Female; Location: Maryland, United States; Sample: Middle School Students Keywords: Alcohol Use; Family Structure; Internal Consistency; Parenting; Predictors of Alcohol Use Questionnaire; Psychosocial Factors; School Adjustment; School Climate; Subjects: Family Structure; Parenting; Prediction; Psychosocial Factors; Questionnaires; Risk Factors; School Adjustment; School Environment; Test Reliability; Underage Drinking;
DO  - 10.1037/t18545-000
L3  - Sample; Full text; 999918545_sample_001.pdf
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-18545-000&site=ehost-live&scope=site
UR  - MORTONB@exchange.NIH.GOV
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-42447-000
AN  - 9999-42447-000
AU  - Yang, Jian
AU  - McCrae, Robert R.
AU  - Costa, Paul T. Jr.
AU  - Dai, Xiaoyang
AU  - Yao, Shuqiao
AU  - Cai, Taisheng
AU  - Gao, Beiling
T1  - Revised NEO Personality Inventory--Chinese Version
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1999///
AD  - McCrae, Robert R., National Institute on Aging Gerontology Research Center, Box 03, 5600 Nathan Shock Drive, Baltimore, Maryland, United States, 21224-6825
AV  - Commercial: No; Permissions: Contact Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-42447-000. Partial author list: First Author & Affiliation: Yang, Jian; National Institutes of Health, Baltimore, Maryland, United States. Release Date: 20150907. Correction Date: 20160613. Instrument Type: Inventory/Questionnaire. Test Format: The measure consists of 240 likert-scale items.. Language: Chinese; English. Constructs: Five Factor Personality Model; Classification: Personality (7200). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300). Other Versions: 9999-03907-000, Revised NEO Personality Inventory, Revision. 
N2  - Administration Method: Paper
AB  - Purpose: The purpose of the Revised NEO Personality Inventory--Chinese Version is to be a measure of the 5-factor personality model in Chinese-speaking populations.
AB  - Description: The Revised NEO Personality Inventory--Chinese Version (Yang et al., 1999) was developed to be a measure of the 5-factor personality model in Chinese-speaking populations. Preparation of this translation of the Revised NEO Personality Inventory (NEO-PI-R; Costa & McCrae, 1992) began with the Hong Kong translation (McCrae, Costa, & Yik, 1996) and its adaptation by J. X. Zhang (personal communication, September 28, 1995) for use in Beijing. Examination suggested that most of the items would be culturally relevant and understandable by Chinese in Mainland China but that some modifications of the translation would be desirable. Major revisions consisted of rephrasing items in a way that would be more suitable for Chinese respondents. The 240-item instrument was administered to 2,000 psychiatric in- and outpatients at 13 sites throughout China. Internal consistency was low for some facet scales, but retest reliability was adequate and the hypothesized factor structure was clearly recovered. Correlations with age, California Psychological Inventory scales, and spouse ratings supported the validity of NEO-PI-R scales, and diagnostic subgroups showed meaningful personality profiles. The 5-factor model (Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness) appeared to be useful for the assessment of personality among Chinese psychiatric patients. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Agreeableness
KW  - Conscientiousness
KW  - Extraversion
KW  - Factor Analysis
KW  - Internal Consistency
KW  - Neuroticism
KW  - Openness
KW  - Revised NEO Personality Inventory--Chinese Version
KW  - Test Development
KW  - Test-Retest Reliability
KW  - Validity
U5  - Revised NEO Personality Inventory--Chinese Version [Test Development]Cross-cultural personality assessment in psychiatric populations: The NEO-PI—R in the People's Republic of China. (AN: 1999-11130-012 from PsycINFO) Yang, Jian; McCrae, Robert R.; Costa, Paul T. Jr.; Dai, Xiaoyang; Yao, Shuqiao; Cai, Taisheng; Gao, Beiling; Sep, 1999. Source: Psychological Assessment. 11(3), American Psychological Association, US; Sep, 1999; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Inpatient; Outpatient; Location: China; Sample: Patients; Volunteers Keywords: Agreeableness; Conscientiousness; Extraversion; Factor Analysis; Internal Consistency; Neuroticism; Openness; Revised NEO Personality Inventory--Chinese Version; Test Development; Test-Retest Reliability; Validity; Subjects: Agreeableness; Conscientiousness; Extraversion; Factor Analysis; Five Factor Personality Model; Foreign Language Translation; NEO Personality Inventory; Neuroticism; Openness to Experience; Test Construction; Test Forms; Test Reliability; Test Validity;
DO  - 10.1037/t42447-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-42447-000&site=ehost-live&scope=site
UR  - jeffm@lpc.grc.nia.nih.gov
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - Gen
ID  - 9999-49634-000
AN  - 9999-49634-000
AU  - Osuch, Elizabeth A.
AU  - Noll, Jennie G.
AU  - Putnam, Frank W.
T1  - Self-Injury Motivation Scale
JF  - PsycTESTS
JO  - PsycTESTS
Y1  - 1999///
AD  - Osuch, Elizabeth A., National Institute of Mental Health, Biological Psychiatry Branch, Bldg. 10, Room 3N 212, MSC 1272, Bethesda, Maryland, United States, 20892-1272
AV  - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1  - Accession Number: 9999-49634-000. Other Names: Self-Injury Motivation Scale--Version 1. Acronyms: SIMS; SIMS-Version 1. Partial author list: First Author & Affiliation: Osuch, Elizabeth A.; National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland, United States. Release Date: 20160808. Instrument Type: Inventory/Questionnaire. Test Location: Table 3, Page 341. Test Format: Responses for the 35 items are on a numerical scale from 0 to 10, anchored at each end with 'never' and 'always,' respectively.. Language: English. Constructs: Self-Injury Motivation; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Other Versions: 9999-48658-000, Self-Injury Motivation Scale--Adolescent Version, Revision. 
N2  - Administration Method: Paper
AB  - Purpose: The Self-Injury Motivation Scale was developed as a self-report measurement for motivation for self-injury.
AB  - Description: The Self-Injury Motivation Scale (SIMS; Osuch, Noll, & Putnam, 1999) is a self-report scale that measures motivation for self-injury. This self-report instrument consists of 35 items. Scree plots, eigenvalues, and preliminary factor analysis supported a six-factor solution for the SIMS. The six factors accounted for 85% of scale variability: Affect Modulation (9 items, e.g., 'To decrease feelings of rage'), Desolation (4 items), Punitive Duality (6 items), Influencing Others (5 items), Magical Control (7 items), and Self-Stimulation (4 items). Subjects are presented with the stem statement, 'I have injured myself to . . .' The response format is a numerical scale from 0 to 10, anchored at each end with 'never' and 'always,' respectively. Subjects respond by circling a number. At the end an additional item read, 'Other reasons not listed. Please describe in the space below,' followed by several blank spaces. In a sample of psychiatric inpatients (N = 99) in U. S., Cronbach's alpha for the SIMS was .96. Split-half correlation was .92 and Guttman split-half reliability was .95. Test-retest reliability was .70. Scale validity was established by face validity and criterion-referenced concurrent validity. The scale takes between 7 to 15 minutes to complete. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW  - Affect Modulation Subscale
KW  - Concurrent Validity
KW  - Desolation Subscale
KW  - Exploratory Factor Analysis
KW  - Face Validity
KW  - Influencing Others Subscale
KW  - Internal Consistency
KW  - Magical Control Subscale
KW  - Punitive Duality Subscale
KW  - Self-Injury Motivation Scale
KW  - Self-Report
KW  - Self-Stimulation Subscale
KW  - Test Development
KW  - Test-Retest Reliability
KW  - Self-Injury Motivation
U5  - Self-Injury Motivation Scale (SIMS, SIMS-Version 1) [Test Development]The motivations for self-injury in psychiatric inpatients. (AN: 2000-13805-006 from PsycINFO) Osuch, Elizabeth A.; Noll, Jennie G.; Putnam, Frank W.; Win, 1999. Source: Psychiatry: Interpersonal and Biological Processes. 62(4), Guilford Publications, US; Win, 1999; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Inpatient; Location: United States; Sample: Psychiatric Inpatients Keywords: Affect Modulation Subscale; Concurrent Validity; Desolation Subscale; Exploratory Factor Analysis; Face Validity; Influencing Others Subscale; Internal Consistency; Magical Control Subscale; Punitive Duality Subscale; Self-Injury Motivation Scale; Self-Report; Self-Stimulation Subscale; Test Development; Test-Retest Reliability; Self-Injury Motivation; Subjects: Factor Analysis; Factor Structure; Motivation; Psychological Assessment; Self-Injurious Behavior; Self-Report; Test Construction; Test Reliability; Test Validity;
DO  - 10.1037/t49634-000
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-49634-000&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - pst
ER  - 

TY  - JOUR
ID  - 107178314
T1  - My turn. Board focuses on the best use of association resources.
AU  - Byram D
Y1  - 1999/01//1999 Jan
N1  - Accession Number: 107178314. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. 
KW  - American Association of Critical-Care Nurses
SP  - 2
EP  - 2
JO  - AACN News
JF  - AACN News
JA  - AACN NEWS
VL  - 16
IS  - 1
CY  - Aliso Viejo, California
PB  - American Association of Critical-Care Nurses
AD  - National Institutes of Health, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107178314&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104719476
T1  - Project MATCH.
AU  - Gordis, E
AU  - Fuller, R
Y1  - 1999/01//
N1  - Accession Number: 104719476. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - Alcoholism -- Rehabilitation
KW  - Clinical Trials
KW  - Psychotherapy -- Methods
KW  - Prospective Studies
KW  - Human
KW  - Multicenter Studies
KW  - Sample Size
KW  - Sensitivity and Specificity
KW  - Treatment Outcomes
KW  - United States
SP  - 57
EP  - 59
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 94
IS  - 1
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0965-2140
AD  - National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20892-7003, USA.
U2  - PMID: 10665095.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104719476&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107231809
T1  - The emerging importance of genetics in epidemiologic research. I. Basic concepts in human genetics and laboratory technology.
AU  - Ellsworth DL
AU  - Manolio TA
Y1  - 1999/01//1999 Jan
N1  - Accession Number: 107231809. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; glossary; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Epidemiological Research
KW  - Genetic Techniques -- Trends
KW  - Genetics, Medical -- Trends
KW  - Genetics, Medical -- Ethical Issues
KW  - Genetics, Medical -- Legislation and Jurisprudence -- United States
KW  - Hereditary Diseases -- Etiology
KW  - Human Genome Project
KW  - DNA
KW  - Genes
KW  - Mutation
KW  - Genetic Markers
KW  - United States
SP  - 1
EP  - 16
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 9
IS  - 1
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: To define a general framework of current approaches to the discovery of disease-associated genes and the role of genetic factors in influencing disease risk through the integration of genome technology and traditional epidemiologic methods. METHODS: An overview of basic concepts in human genetics, laboratory methodology for measuring genetic variation believed to influence common diseases, and issues concerning preparation and utilization of genetic materials is provided as a foundation for genetic epidemiologic research. RESULTS: Identification and characterization of human genetic variation is providing new risk factors for disease in the form of DNA sequence variation. The availability of genetic material from participants in large epidemiologic studies and appropriate informed consent represents an invaluable resource for exploring genetic and environmental influences on disease risk. CONCLUSIONS: Advances in genome technology coupled with vast amounts of genetic data resulting from the Human Genome Project are broadening the scope of epidemiologic research and providing tools to identify individuals at increased risk of disease. Combining diverse expertise from the fields of epidemiology and human genetics provides unique opportunities to localize disease-susceptibility genes and examine molecular mechanisms of complex disease etiology.
SN  - 1047-2797
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Dr., MSC 7934, Bethesda, MD 20892-7934
U2  - PMID: 9915603.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107231809&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107180930
T1  - Manometric study of paranasal sinus mucoceles.
AU  - Kass ES
AU  - Fabian RL
AU  - Montgomery WM
Y1  - 1999/01//1999 Jan
N1  - Accession Number: 107180930. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0407300. 
KW  - Manometry -- Methods
KW  - Mucocele -- Surgery
KW  - Paranasal Sinus Diseases -- Surgery
KW  - Mucocele -- Etiology
KW  - Mucocele -- Radiography
KW  - Paranasal Sinus Diseases -- Etiology
KW  - Paranasal Sinus Diseases -- Radiography
KW  - Preoperative Care
KW  - Retrospective Design
KW  - Tomography, X-Ray Computed
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Aged, 80 and Over
KW  - Biophysiological Methods
KW  - Biophysical Instruments
KW  - Pressure
KW  - Human
SP  - 63
EP  - 66
JO  - Annals of Otology, Rhinology & Laryngology
JF  - Annals of Otology, Rhinology & Laryngology
JA  - ANN OTOL RHINOL LARYNGOL
VL  - 108
IS  - 1
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0003-4894
AD  - National Institutes of Health, Building 10, Room 8B07, 10 Central Drive MSC 1750, Bethesda, Md 20892-1750
U2  - PMID: 9930542.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107180930&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lambert, J.S.
AU  - Moye, J.J.
T1  - Current Issues in the Immunoprophylaxis of Vertical Transmission of HIV.
JO  - BioDrugs
JF  - BioDrugs
Y1  - 1999/01//
VL  - 11
IS  - 1
M3  - Article
SP  - 31
EP  - 41
PB  - Springer Science & Business Media B.V.
SN  - 11738804
AB  - Humoral immunity is thought to play an important role in the natural history of HIV infection. It has been hypothesised that the presence of high titre neutralising antibody may protect against the maternal-fetal transmission of HIV-1 infection. HIV-Ig is a passive antibody preparation consisting of highly purified immune globulin containing high titres of antibody to HIV structural proteins. It contains considerable functional antibody in virus neutralisation and antibody dependent cytotoxicity assays. This product (and others) have undergone extensive investigation in preclinical (in vitro and animal models) and clinical trials. In a randomised, double-blind trial, pregnant women with HIV infection who were receiving antiretroviral therapy received either HIV-Ig or control intravenous Ig. While transmission rate was 5 to 6% in both treatment and control arms (sample size was too small to show a difference), infected infants who received HIV-Ig had a delayed time to culture positivity versus those receiving intravenous Ig, suggesting that HIV-Ig may have the ability to modify disease but not prevent infection. While this study did not prove an effect of HIV-Ig it did prove an effect of antiretroviral therapy in a population of women with prior zidovudine experience. Passive antibody preparations (HIV-Ig and monoclonal antibodies) may have the potential to decrease perinatal transmission in combination with antiretroviral agents, to levels less than 5%. Special niches where immunoglobulins and HIV vaccines may play a role, include treatment of infants born to women who do not receive prenatal care, or where the diagnosis of HIV in mother and infant is made only following delivery: a post-exposure prophylaxis strategy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of BioDrugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV infections -- Transmission
KW  - IMMUNOLOGY
KW  - MATERNAL-fetal exchange
KW  - Antivirals, therapeutic-use
KW  - Fetus
KW  - HIV-gp120-vaccine-gene-therapy-Geniva-Chiron, ther
KW  - HIV-immune-globulin, therapeutic-use
KW  - HIV-infections, prevention
KW  - Immunomodulators, therapeutic-use
KW  - Infants
KW  - Intravenous
KW  - Monoclonal-antibodies, therapeutic-use
KW  - Pregnancy
KW  - Research-and-development
KW  - Reviews-on-treatment
KW  - Vaccines, therapeutic-use
KW  - Zidovudine, therapeutic-use
N1  - Accession Number: 9522657; Lambert, J.S. 1 Moye, J.J. 2; Affiliation:  1: University of Maryland Institute of Human Virology, Division of Clinical Research, Baltimore, Maryland, USA  2: National Institutes of Health, National Institute of Child Health and Human Development, Center for Research for Mothers and Children, Pediatric, Adolescent and Maternal AIDS Branch, Bethesda, Maryland, USA; Source Info: 1999, Vol. 11 Issue 1, p31; Subject Term: HIV infections -- Transmission; Subject Term: IMMUNOLOGY; Subject Term: MATERNAL-fetal exchange; Author-Supplied Keyword: Antivirals, therapeutic-use; Author-Supplied Keyword: Fetus; Author-Supplied Keyword: HIV-gp120-vaccine-gene-therapy-Geniva-Chiron, ther; Author-Supplied Keyword: HIV-immune-globulin, therapeutic-use; Author-Supplied Keyword: HIV-infections, prevention; Author-Supplied Keyword: Immunomodulators, therapeutic-use; Author-Supplied Keyword: Infants; Author-Supplied Keyword: Intravenous; Author-Supplied Keyword: Monoclonal-antibodies, therapeutic-use; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: Research-and-development; Author-Supplied Keyword: Reviews-on-treatment; Author-Supplied Keyword: Vaccines, therapeutic-use; Author-Supplied Keyword: Zidovudine, therapeutic-use; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Orbach, Yael
AU  - Lamb, Michael E.
T1  - ASSESSING THE ACCURACY OF A CHILD'S ACCOUNT OF SEXUAL ABUSE: A CASE STUDY.
JO  - Child Abuse & Neglect
JF  - Child Abuse & Neglect
Y1  - 1999/01//
VL  - 23
IS  - 1
M3  - Article
SP  - 91
EP  - 98
SN  - 01452134
AB  - Objective: The objective of the case study reported in this paper was to examine the accuracy of one child's account of a sexually abusive incident. The availability of an audio recording of the last in a series of abusive incidents enabled us to assess accuracy in greater detail than has hitherto been possible in forensic contexts. Methods: Information given by the victim during an investigative interview was compared with an audio-taped record of the incident. Content analyses of the interview involved quantitative and qualitative analyses of the victim's account, and a qualitative analysis of the eliciting utterances. A CBCA analysis was performed on the victim's account to assess its purported credibility. Results: Over 50% of the informative details reported by the victim were corroborated by the audio-recorded account (of which 98% were central, i.e., allegation related and 64% were confirmed by more than one source (audio-recording, suspect, witness). A total of 10 CBCA criteria were present in the victim's free-narrative account of the last abusive incident. Conclusions: Our findings confirm that children can indeed provide remarkably detailed and accurate accounts of their experiences. Published by Elsevier Science Ltd. (English) [ABSTRACT FROM AUTHOR]
AB  - Objetivo: el objetivo del estudio de casE que se presenta en este artículo fue examinar la precisión del relato que realiza un/a niño/a acerca de un incidente de abuse sexual infantil. La accesibilidad de una grabación de sonido realizada durante el último de una serie de incidentes de abusE sexual permitió evaluar la precisión del relato con mayor detalle de lo que había sido posible hasta ahora en los contextos forenses. Método: La información dada por la víctima durante la entrevista de investigación fue comparada con la grabación de sonido realizada durante el incidente. El estudio del contenido de la entrevista implicó un análisis cuantitativo y cualitativo del relato de la víctima, y un análisis cualitativo de las declaraciones obtenidas. Se llevó a cabo un análisis CBCA sobre el relato de la víctima con el objetivo de evaluar su supuesta credibilidad. Resultados: Más del 50% de los detalles informativos notidicados pEr la víctima fueron corroborados por el contenido de la grabación. El 98% de estos detalles corroborados fueron catalogados como información central, es decir, relacionada con el contenido de la acusación. Un 64% de estos detalles fueron confirmados por más de una fuente en la grabación, sea el sospechoso o el testigo. Un total de 10 criterios CBCA estaban presentes en la narración libre que hizo la víctima acerca del último episodio de maltrato. Conclusión: Nuestros hallazgos confirman que los niños pueden proporcionar relatos precisos y especialmente detallados de sus propias experiencias. (Spanish) [ABSTRACT FROM AUTHOR]
AB  - Objectif: Le but de cette étude de cas a été d'évaluer l'exactitude du récit de l'enfant concernant l'incident sexuel abusif. La disponibilité d'un enregistrement auditif du dernier d'une série d'incidents abusifs nous a permis d'évaluer l'exactitude du récit de façon plus détaillée que ce qu'avait été possible jusque là dans un contexte légal. Méthode: L'information donnée par la victime lors de l'interrogatoire d'investigation a été comparé à l'enregistrement de l'incident sur cassette auditive. Les analyses du contenu de l'interrogatoire impliquaient des analyses quantitatives et qualitatives du compte rendu de la victime et une analyse qualitative des expressions obtenues. Une analyse CBCA a été effectuée sur le récit de la victime pour en analyser sa crédibilité. Résultats: Plus de 50% des details informatifs rapportés par la victime étalent corroborés par l'enregistrement auditif (dont 98% étalent d'importance centrale, e.a. liés à l'accusation et 64% étaient confirmés par plus d'une source en dehors de l'enregistrement auditif, suspect, témoins). Un total de 10 critères CBCA étalent presents lors du récit libre par la victime du demier incident abusif. Conclusion: Nos données confirment que les enfants peuvent en effet donner des récits remarquablement détaillés et exacts de leurs expériences. (French) [ABSTRACT FROM AUTHOR]
AB  - Copyright of Child Abuse & Neglect is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD sexual abuse
KW  - SEXUALLY abused children
KW  - SEXUAL abuse victims
KW  - FORENSIC acoustics
KW  - WITNESSES
KW  - Accuracy
KW  - Child witness
KW  - Credibility
KW  - Memory
KW  - Sexual abuse
N1  - Accession Number: 1450602; Orbach, Yael 1 Lamb, Michael E. 1; Affiliation:  1: Section of Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, USA; Source Info: Jan1999, Vol. 23 Issue 1, p91; Subject Term: CHILD sexual abuse; Subject Term: SEXUALLY abused children; Subject Term: SEXUAL abuse victims; Subject Term: FORENSIC acoustics; Subject Term: WITNESSES; Author-Supplied Keyword: Accuracy; Author-Supplied Keyword: Child witness; Author-Supplied Keyword: Credibility; Author-Supplied Keyword: Memory; Author-Supplied Keyword: Sexual abuse; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107163343
T1  - Progress toward understanding craniofacial malformations.
AU  - Nuckolls GH
AU  - Shum L
AU  - Slavkin HC
Y1  - 1999/01//1999 Jan
N1  - Accession Number: 107163343. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 9102566. 
KW  - Musculoskeletal Abnormalities -- Etiology
KW  - Musculoskeletal Abnormalities -- Familial and Genetic
KW  - Genetics
KW  - Cell Physiology
KW  - Mutation
KW  - Craniosynostoses
SP  - 12
EP  - 26
JO  - Cleft Palate-Craniofacial Journal
JF  - Cleft Palate-Craniofacial Journal
JA  - CLEFT PALATE CRANIOFACIAL J
VL  - 36
IS  - 1
CY  - Lawrence, Kansas
PB  - Allen Press Publishing Services Inc.
AB  - Significant advances in the study of the human face have revealed the genetic and gene-environment bases of numerous common and rare craniofacial disorders. Classification of craniofacial malformations based on clinical phenotypes is sometimes quite different from the genetic findings of patients. Different mutations in a single gene can cause distinct syndromes, and mutations in different genes can cause the same syndrome. The extracellular signaling molecule SHH, fibroblast growth factor receptors, and transcription factors GLI3, MSX2, and TWIST are discussed as examples of molecules involved in interrelated signal transduction networks regulating craniofacial development. Progress in the understanding of normal and abnormal craniofacial development, through the study of morphoregulatory signaling pathways, has benefited from multifactorial approaches recommended 40 years ago at the National Institute of Dental Research-sponsored landmark Gatlinburg Conference. The utilization of biochemistry, protein structure analyses, tissue culture, and animal model systems for developmental genetics has resulted in remarkable scientific advances. The evolutionary conservation of morphoregulatory pathways has revealed the homology of genes associated with human craniofacial malformations and their counterparts that regulate the morphogenesis of fruit flies continued investments in basic, translational, and patient-oriented research regarding normal and abnormal craniofacial development will translate into substantial improvements in the prevention, diagnosis, and treatment of craniofacial diseases and disorders.
SN  - 1055-6656
AD  - Craniofacial Development Section, National Institutes of Health, 6 Center Dr, Room 324 MSC2745, Bethesda, MD 20892-2745 email gn18s@nih.gov
U2  - PMID: 10067756.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wagner, K.-U.
AU  - Dierisseau, P.
AU  - Hennighausen, L.
T1  - Assignment1  of the murine tumor susceptibility gene 101 (tsg101 ) and a processed tsg101 pseudogene (tsg101-ps1 ) to mouse chromosome 7 band B5 and chromosome 15 band D1 by in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1999/01//
VL  - 84
IS  - 1/2
M3  - Article
SP  - 87
EP  - 88
SN  - 03010171
AB  - Tsg101 was discovered in a mouse's NIH 3T3 fibroblasts and the functional inactivation of this gene leads to cell transformation and tumors. The human TSG1O1 gene, which encodes a protein that is 94% similar to the mouse counterpart, has been mapped to chromosome, a region that is associated with LOH in different types of tumors. In the mouse, a tsg101 sequence was detected on chromosome 7 using a mapping panel of hybrid cell lines. However, recent studies have shown that the mouse genome contains at least one processed pseudogene that is nearly identical to the tsg101 cDNA sequence.
KW  - MOUSE leukemia complex
KW  - FIBROBLASTS
KW  - CELL transformation
KW  - GENE mapping
KW  - CELL lines
KW  - CELL hybridization
KW  - NUCLEOTIDE sequence
N1  - Accession Number: 12184414; Wagner, K.-U. 1; Email Address: KUW@NIH.GOV Dierisseau, P. 1 Hennighausen, L. 1; Affiliation:  1: Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Disease, National Institutes of Health, Bethesda MD (USA); Source Info: Jan1999, Vol. 84 Issue 1/2, p87; Subject Term: MOUSE leukemia complex; Subject Term: FIBROBLASTS; Subject Term: CELL transformation; Subject Term: GENE mapping; Subject Term: CELL lines; Subject Term: CELL hybridization; Subject Term: NUCLEOTIDE sequence; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000015221
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12184414&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lee, J.-H.
AU  - Cho, K.-W.
T1  - Assignment1 of TCRB encoding the T-cell receptor beta chain gene to cat chromosome A2q25–q26 by fluorescence in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1999/01//
VL  - 84
IS  - 1/2
M3  - Article
SP  - 109
EP  - 110
SN  - 03010171
AB  - A majority of hematopoietic malignancies carry non-random chromosomal alterations therefore genes located at recurring chromosomal breakpoints are directly involved in tumor pathogenesis. The most frequent translocations encountered in B-cell lymphomas of human involved the immunoglobulin gene loci. Many of the lymphomas are associated with feline leukemia virus(FeLV) infections in cats(Felis catus), and these lymphomas are of T-cell origin. FeLV-induced T-cell lymphoma has been verified by the demonstration of T-cell receptor &b.beta; gene rearrangements.
KW  - BLOOD diseases
KW  - CARCINOGENESIS
KW  - LYMPHOMAS
KW  - IMMUNOGLOBULINS
KW  - ANTIBODY diversity
KW  - FLUORESCENCE in situ hybridization
N1  - Accession Number: 12184403; Lee, J.-H. 1; Email Address: jhlee@gshp.gsnu.ac.kr Cho, K.-W. 2; Affiliation:  1: Department of Pathology, College of Medicine, Gyeongsang National University, Chinju (Korea)  2: Laboratory of Genomic Diversity, National Cancer Institute, Frederick MD (USA); Source Info: Jan1999, Vol. 84 Issue 1/2, p109; Subject Term: BLOOD diseases; Subject Term: CARCINOGENESIS; Subject Term: LYMPHOMAS; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIBODY diversity; Subject Term: FLUORESCENCE in situ hybridization; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000015232
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Buesing, M. A.;
AU  - McSweegan, E.;
T1  - Submitting biologics applications to the Center for Biologics Evaluation and Research electronically
CT  - Submitting biologics applications to the Center for Biologics Evaluation and Research electronically
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1999/01/01/
VL  - 33
IS  - Jan
SP  - 1
EP  - 5
SN  - 00928615
AD  - Ctr. for Biologics Evaluation and Research, FDA, Rockville, MD, USA Reprints: NIH, NIAID/DMID, Solar Bldg., Rm. 3A34, Bethesda, MD 20892, USA Internet: mcsweegan@nih.gov
N1  - Accession Number: 37-04361; Language: English; References: 9; Journal Coden: DGIJB9; Section Heading: Legislation, Laws and Regulations; Information Processing and Literature; Abstract Author: Elizabeth G. Rudnic
N2  - New guidance from the U.S. Food and Drug Administration's Center for Biologics Evaluation and Research for the electronic submission of biologic and product license applications, including case report forms, tabulations, statistical data, and lot release protocols, is presented.
KW  - Food and Drug Administration (U.S.)--biologicals--electronic submission;
KW  - Biologicals--Food and Drug Administration--electronic submission;
KW  - Guidelines--Food and Drug Administration--electronic submission;
KW  - Reports--biologicals--FDA;
KW  - Forms--biologicals--FDA reports;
KW  - Statistics--biologicals--FDA reports;
KW  - Drugs--new--biologicals;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Miller, Heather G.
AU  - Cain, Virginia S.
AU  - Rogers, Susan M.
AU  - Gribble, James N.
AU  - Turner, Charles F.
T1  - Correlates of Sexually Transmitted Bacterial Infections Among U.S. Women in 1995.
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
Y1  - 1999/01//Jan/Feb99
VL  - 31
IS  - 1
M3  - Article
SP  - 4
EP  - 23
PB  - Guttmacher Institute, Inc.
SN  - 00147354
AB  - Context: Sexually transmitted diseases (STDs) of bacterial origin such as gonorrhea and chlamydial infection can lead to pelvic inflammatory disease (PID) and infertility. Identifying behaviors and characteristics associated with infection may assist in preventing these often asymptomatic diseases and their sequelae. Methods: Data from 9,882 sexually active women who participated in the 1995 National Survey of Family Growth describe the characteristics of women who report a history of infection with a bacterial STD or of treatment for PID. Multivariate analysis is used to determine which demographic characteristics and sexual and health-related behaviors affect the likelihood of infection or the occurrence of complications. Results: Overall, 6% of sexually active women reported a history of a bacterial STD, and 8% reported a history of PID. Women who first had sexual intercourse before age 15 were nearly four times as likely to report a bacterial STD, and more than twice as likely to report PID, as were women who first had sex after age 18. Having more than five lifetime sexual partners also was associated with both having an STD and having PID. PID was more common among women reporting a history of a bacterial STD (23%) than among women who reported no such history (7%). In multivariate analyses, age, race, age at first intercourse and lifetime number of sexual partners had a significant effect on the risk of a bacterial STD. Education, age, a history of IUD use, douching and a history of a bacterial STD had a significant impact on the risk of PID, but early onset of intercourse did not, and lifetime number of partners had only a marginal effect. Conclusions: The pattern of characteristics and behaviors that place women at risk of infection with bacterial STDs is not uniform among groups of women. Further, the level of self-reported PID would suggest higher rates of gonorrhea and chlamydial infection than reported. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Family Planning Perspectives is the property of Guttmacher Institute, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SEXUALLY transmitted diseases
KW  - GONORRHEA
KW  - CHLAMYDIA infections
KW  - PELVIC inflammatory disease
KW  - WOMEN -- Health
KW  - SEXUAL intercourse
N1  - Accession Number: 1657102; Miller, Heather G. 1 Cain, Virginia S. 2 Rogers, Susan M. 3 Gribble, James N. 4 Turner, Charles F. 5; Affiliation:  1: Director, Program in Health and Behavioral Measurement, Research Triangle Institute, Washington, DC  2: Special Assistant to the Director, Office of Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, MD  3: Research Associate, Program in Health and Behavioral Measurement, Research Triangle Institute, Washington, DC  4: Research Demographer, Program in Health and Behavioral Measurement, Research Triangle Institute, Washington, DC  5: Senior Scientist, Program in Health and Behavioral Measurement, Research Triangle Institute, Washington, DC; Source Info: Jan/Feb99, Vol. 31 Issue 1, p4; Subject Term: SEXUALLY transmitted diseases; Subject Term: GONORRHEA; Subject Term: CHLAMYDIA infections; Subject Term: PELVIC inflammatory disease; Subject Term: WOMEN -- Health; Subject Term: SEXUAL intercourse; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 6875
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107183452
T1  - Genetics: an explosion of knowledge is transforming clinical practice.
AU  - Collins FS
Y1  - 1999/01//
N1  - Accession Number: 107183452. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985102R. 
KW  - Genetics, Medical -- Trends
KW  - Geriatrics -- Trends
KW  - Genetics, Medical -- Methods
KW  - Human Genome Project
KW  - Breast Neoplasms -- Diagnosis
KW  - Breast Neoplasms -- Familial and Genetic
KW  - Gene Therapy -- Trends
KW  - Parkinson Disease -- Diagnosis
KW  - Parkinson Disease -- Familial and Genetic
KW  - Education, Continuing (Credit)
KW  - Aged
KW  - Male
KW  - Female
SP  - 41
EP  - 48
JO  - Geriatrics
JF  - Geriatrics
JA  - GERIATRICS
VL  - 54
IS  - 1
CY  - North Olmsted, Ohio
PB  - Advanstar Communications Inc.
SN  - 0016-867X
AD  - Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 9934355.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - CHAP
AU  - Kneller, Robert
AD  - National Cancer Institute
A2  - Branscomb, Lewis M.
A2  - Kodama, Fumio
A2  - Florida, Richard
T1  - Intellectual Property Rights and University-Industry Technology Transfer in Japan
T2  - Industrializing knowledge: University-industry linkages in Japan and the United States
PB  - Cambridge and London:
PB  - MIT Press
Y1  - 1999///
SP  - 307
EP  - 347
N1  - Accession Number: 0580250; Reviewed Book ISBN: 0-262-02465-9; Keywords: Intellectual Property Rights;  Property Rights;  Property;  Technology; Geographic Descriptors: Japan; Geographic Region: Asia; Publication Type: Collective Volume Article; Update Code: 200110
KW  - Intellectual Property and Intellectual Capital          O34
KW  - Technological Change: Choices and Consequences; Diffusion Processes          O33
KW  - Management of Technological Innovation and R&D          O32
KW  - Analysis of Education          I21
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - CHAP
AU  - Kneller, Robert
AD  - National Cancer Institute
A2  - Branscomb, Lewis M.
A2  - Kodama, Fumio
A2  - Florida, Richard
T1  - University-Industry Cooperation in Biomedical R&D in Japan and the United States: Implications for Biomedical Industries
T2  - Industrializing knowledge: University-industry linkages in Japan and the United States
PB  - Cambridge and London:
PB  - MIT Press
Y1  - 1999///
SP  - 410
EP  - 438
N1  - Accession Number: 0580254; Reviewed Book ISBN: 0-262-02465-9; Keywords: R&D; Geographic Descriptors: Japan; U.S.; Geographic Region: Asia; Northern America; Publication Type: Collective Volume Article; Update Code: 200110
KW  - Management of Technological Innovation and R&D          O32
KW  - Analysis of Education          I21
KW  - Chemicals; Rubber; Drugs; Biotechnology          L65
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0580254&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Martin, Donald E. K.
AU  - Troendale, James F.
AD  - Howard U
AD  - National Institutes of Health
T1  - Paired Comparison Models Applied to the Design of the Major League Baseball Play-offs
JO  - Journal of Applied Statistics
JF  - Journal of Applied Statistics
Y1  - 1999/01//
VL  - 26
IS  - 1
SP  - 69
EP  - 80
SN  - 02664763
N1  - Accession Number: 0492266; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199906
N2  - This paper presents an analysis of the effect of various baseball play-off configurations on the probability of advancing to the World Series. Play-off games are assumed to be independent. Several paired comparisons models are considered for modeling the probability of a home team winning a single game as a function of the winning percentages of the contestants over the course of the season. The uniform and logistic regression models are both adequate, whereas the Bradley-Terry model (modified for within-pair order effects, i.e. the home field advantage) is not. The single-game probabilities are then used to compute the probability of winning the play-offs under various structures. The extra round of play-offs, instituted in 1994, significantly lowers the probability of the team with the best record advancing to the World Series, whereas home field advantage and the different possible play-off draws have a minimal effect.
KW  - Sports; Gambling; Restaurants; Recreation; Tourism          L83
L3  - http://www.tandfonline.com/loi/cjas20
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UR  - http://www.tandfonline.com/loi/cjas20
DP  - EBSCOhost
DB  - ecn
ER  - 
TY  - GEN
ID  - 89337132
T1  - Clinical radiosensitization: why it does and does not work.
AU  - Coleman, C. Norman
AU  - Mitchell, James B.
AU  - Coleman, C N
AU  - Mitchell, J B
Y1  - 1999/01//1/1/1999
N1  - Accession Number: 89337132. Language: English. Entry Date: 19990501. Revision Date: 20161120. Publication Type: commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins); Work Environment Scale (WES) (Moos et al). NLM UID: 8309333. 
KW  - Neoplasms -- Radiotherapy
KW  - Radiation-Sensitizing Agents -- Therapeutic Use
KW  - Antineoplastic Agents -- Therapeutic Use
KW  - Carboplatin -- Therapeutic Use
KW  - Drug Administration Schedule
KW  - Neoplasms -- Drug Therapy
KW  - Combined Modality Therapy
KW  - Deoxyribonucleosides -- Therapeutic Use
KW  - Radiation-Sensitizing Agents -- Administration and Dosage
KW  - Scales
SP  - 1
EP  - 3
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
SN  - 0732-183X
AD  - Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA
AD  - Radiation Biology Branch, National Cancer Institute, Bethesda, MD
U2  - PMID: 10458210.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89337165
T1  - Phase I study in cancer patients of a replication-defective avipox recombinant vaccine that expresses human carcinoembryonic antigen.
AU  - Marshall, John L.
AU  - Hawkins, Michael J.
AU  - Kwong Y. Tsang
AU  - Richmond, Ellen
AU  - Pedicano, James E.
AU  - MingZhu Zhu
AU  - Schlom, Jeffrey
AU  - Marshall, J L
AU  - Hawkins, M J
AU  - Tsang, K Y
AU  - Richmond, E
AU  - Pedicano, J E
AU  - Zhu, M Z
AU  - Schlom, J
Y1  - 1999/01//1/1/1999
N1  - Accession Number: 89337165. Language: English. Entry Date: 19990501. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). Grant Information: U01 CA62500/CA/NCI NIH HHS/United States. NLM UID: 8309333. 
KW  - Cancer Vaccines -- Therapeutic Use
KW  - Antigens, Tumor -- Immunology
KW  - Carcinoma -- Therapy
KW  - Female
KW  - Antigens, Tumor
KW  - Male
KW  - Viruses
KW  - Adult
KW  - Cancer Vaccines -- Immunology
KW  - HLA Antigens -- Analysis
KW  - Aged, 80 and Over
KW  - Middle Age
KW  - Aged
KW  - Human
KW  - T Lymphocytes -- Immunology
KW  - Carcinoma -- Immunology
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Scales
SP  - 332
EP  - 337
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 1
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: A phase I clinical trial in patients with advanced carcinoma was conducted, using a replication-defective avipox vaccine containing the gene for the human carcinoembryonic antigen (CEA). The canarypox vector, designated ALVAC, has the ability to infect human cells but cannot replicate.Patients and Methods: The recombinant vaccine, designated ALVAC-CEA, was administered intramuscularly three times at 28-day intervals. Each cohort of six patients received three doses of either 2.5 x 10(5), 2.5 x 10(6), or 2.5 x 10(7) plaque-forming units of vaccine.Results: The vaccine was well tolerated at all dose levels and no significant toxicity was attributed to the treatment. No objective antitumor response was observed during the trial in patients with measurable disease. Studies were conducted to assess whether ALVAC-CEA had the ability to induce cytolytic T-lymphocyte (CTL) responses in patients with advanced cancer. Peripheral blood mononuclear cells (PBMCs) from patients with the MHC class I A2 allele were obtained before vaccine administration and 1 month after the third vaccination. Peripheral blood mononuclear cells were incubated with the CEA immunodominant CTL epitope carcinoembryonic antigen peptide-1 and interleukin 2 and quantitated using CTL precursor frequency analysis. In seven of nine patients evaluated, statistically significant increases in CTL precursors specific for CEA were observed in PBMCs after vaccination, compared with before vaccination.Conclusion: These studies constitute the first phase I trial of an avipox recombinant in cancer patients. The recombinant vaccine ALVAC-CEA seems to be safe and has been demonstrated to elicit CEA-specific CTL responses. These studies thus form the basis for the further clinical exploration of the ALVAC-CEA recombinant vaccine in phase I/II studies in protocols designed to enhance the generation of human T-cell responses to CEA.
SN  - 0732-183X
AD  - Georgetown University Medical Center, Vincent T. Lombardi Cancer Center, Washington, DC
AD  - Laboratory of Tumor Immunology and Biology, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, MD
AD  - Georgetown University Medical Center, Vincent T. Lombardi Cancer Center, Washington, DC 20007, USA
U2  - PMID: 10458251.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=89337165&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Chao, Linda L.
AU  - Martin, Alex
T1  - Cortical Regions Associated with Perceiving, Naming, and Knowing about Colors.
JO  - Journal of Cognitive Neuroscience
JF  - Journal of Cognitive Neuroscience
Y1  - 1999/01//
VL  - 11
IS  - 1
M3  - Article
SP  - 25
EP  - 35
PB  - MIT Press
SN  - 0898929X
AB  - Positron emission tomography (PET) was used to investigate whether retrieving information about a specific object attribute requires reactivation of brain areas that mediate perception of that attribute. During separate PET scans, subjects passively viewed colored and equiluminant gray-scale Mondrians, named colored and achromatic objects, named the color of colored objects, and generated color names associated with achromatic objects. Color perception was associated with activations in the lingual and fusiform gyri of the occipital lobes, consistent with previous neuroimaging and human lesion studies.Retrieving information about object color (generating color names for achromatic objects relative to naming achromatic objects) activated the left inferior temporal,left frontal,and left posterior parietal cortices, replicating previous findings from this laboratory. When subjects generated color names for ach romatic objects relative to the low-level baseline of viewing gray-scale Mondrians, additional activations in the left fusiform/lateral occipital region were detected. However, these activations were lateral to the occipital regions associated with color perception and identical to occipital regions activated when subjects simply named achromatic objects relative to the same low-level baseline. This suggests that the occipital activations associated with retrieving color information were due to the perception of object form rather than to the top-down influence of brain areas that mediate color perception. Taken together, these results indicate that retrieving previously acquired information about an object's typical color does not require reactivation of brain regions that subserve color perception. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COGNITION
KW  - BRAIN
KW  - EMISSION tomography
KW  - SCIENCE
N1  - Accession Number: 1555040; Chao, Linda L. 1 Martin, Alex 1; Affiliation:  1: National Institutes of Health; Source Info: Jan99, Vol. 11 Issue 1, p25; Subject Term: COGNITION; Subject Term: BRAIN; Subject Term: EMISSION tomography; Subject Term: SCIENCE; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 11p; Illustrations: 3 Color Photographs, 2 Black and White Photographs, 1 Diagram; Document Type: Article; Full Text Word Count: 6983
L3  - 10.1162/089892999563229
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=1555040&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107106860
T1  - Longitudinal study of psychological distress symptoms in HIV-infected, school-aged children...Co-published simultaneously in Journal of HIV/AIDS Prevention & Education for Adolescents & Children (The Haworth Press, Inc.) Vol. 3, No. 1/2, 1999, pp. 13-36; and: HIV Affected and Vulnerable Youth: Prevention Issues and Approaches (ed: Susan Taylor-Brown and Alejandro Garcia) the The Haworth Press, Inc., 1999, pp. 13-36
AU  - Wiener L
AU  - Battles H
AU  - Riekert KA
Y1  - 1999/01//
N1  - Accession Number: 107106860. Language: English. Entry Date: 20000501. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Health Promotion/Education; Peer Reviewed; USA. Instrumentation: Beck Depression Inventory (BDI); Demographic Questionnaire; Health Status Questionnaire; Spielberger State-Trait Anxiety Inventory (STAI); Child Behavior Checklist (CBCL) (Achenbach); Dominic (Valla et al); Family Environment Scale (FES) (Moos and Moos). NLM UID: 9613967. 
KW  - HIV-Infected Patients -- Psychosocial Factors -- In Infancy and Childhood
KW  - Stress, Psychological -- Epidemiology -- In Infancy and Childhood
KW  - Mental Health -- Evaluation -- In Infancy and Childhood
KW  - Prospective Studies
KW  - Stress, Psychological -- Symptoms
KW  - Parents
KW  - Child
KW  - Interviews
KW  - Demography
KW  - Male
KW  - Female
KW  - Whites
KW  - Blacks
KW  - Hispanics
KW  - Psychological Tests
KW  - Self Report
KW  - Summated Rating Scaling
KW  - Family Relations -- Evaluation
KW  - Questionnaires
KW  - DSM
KW  - One-Way Analysis of Variance
KW  - Independent Variable
KW  - P-Value
KW  - Descriptive Statistics
KW  - Repeated Measures
KW  - Analysis of Variance
KW  - Severity of Illness
KW  - Separation Anxiety -- In Infancy and Childhood
KW  - Depression -- In Infancy and Childhood
KW  - Child Behavior Checklist
KW  - Human
SP  - 13
EP  - 36
JO  - Journal of HIV/AIDS Prevention & Education for Adolescents & Children
JF  - Journal of HIV/AIDS Prevention & Education for Adolescents & Children
JA  - J HIV AIDS PREV EDUC ADOLESC CHILD
VL  - 3
IS  - 1/2
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - Despite the growing numbers of HIV-infected school-aged children, we know very little about the mental health status of this group. This longitudinal study examined the frequency of psychological distress symptoms in HIV-infected children between the ages of 6 and 11 years at three time points over a period of two and one-half years. Children were assessed using the Dominic, a pictorial instrument that assesses for 7 psychological distress symptoms of childhood. In addition, family and demographic variables were collected at Time 1. Children were found to be relatively well-adjusted, with low to moderate incidence of psychological distress. While there were no significant changes in frequency of psychological distress symptoms from Time 1 to Time 3, the prevalence of overanxious and depressive symptomatology increased over time. Implications for clinical practice and future research will be discussed.
SN  - 1069-837X
AD  - Pediatric HIV Psychosocial Support Program, HIV/AIDS Malignancy Branch, National Cancer Institute, 9000 Rockville Pike, Building 10/Room 13N240, Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107106860&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Jakob, Thilo
AU  - Brown, Martin J.
AU  - Udey, Mark C.
T1  - Characterization of E-Cadherin-Containing Junctions Involving Skin-Derived Dendritic Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1999/01//
VL  - 112
IS  - 1
M3  - Article
SP  - 102
EP  - 108
SN  - 0022202X
AB  - Adherens junctions are sites of contact between epithelial cells in which adhesion is mediated by homophilic interactions of classical cadherins that are linked to the cytoskeleton via catenins. E-cadherin constitutes the major adhesion molecule in adherens junctions of keratinocytes (KC) and mediates the binding of Langerhans cells to KC in vitro. To characterize structures responsible for E-cadherin-mediated binding of Langerhans cells, we utilized Langerhans cells-like fetal skin-derived dendritic cells (FSDDC) capable of E-cadherin-mediated adhesion. Confocal microscopy of FSDDC aggregates demonstrated colocalization of E-cadherin and catenins to areas of cell–cell contact. Immunopreciptiation confirmed a physical association of E-cadherin with intracellular catenins (α-, β-, γ-catenin/plakoglobin and p120CAS). Transmission electron microscopy of FSDDC aggregates revealed structures with features of adherens junctions in areas of cell–cell contact, and post-embedding immunoelectron microscopy localized β-catenin to these regions. To characterize junctions that accounted for the adhesion of Langerhans cells-like dendritic cells and KC, disaggregated FSDDC were cocultured with primary murine KC. Transmission electron microscopy analysis of cocultures demonstrated FSDDC-KC contacts that were analogous to those seen in FSDDC aggregates. Confocal microscopy demonstrated focal accumulations of E-cadherin and colocalization of β-catenin in areas of contact between KC and immature (Langerhans cell-like) dendritic cells, but not in areas of contact between KC and mature (lymph node dendritic cell-like) dendritic cells. E-cadherin in Langerhans cells appears to be localized in structures that resemble adherens junctions formed by nonpolarized epithelial cells. Loss of ability to form or maintain these structures after the induction of Langerhans cells activation/maturation likely results in the attenuation of... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SKIN
KW  - LANGERHANS cells
KW  - CONFOCAL microscopy
KW  - TRANSMISSION electron microscopy
KW  - adhesion
KW  - dendritic cell maturation
KW  - Langerhans cells
N1  - Accession Number: 5167133; Jakob, Thilo 1 Brown, Martin J. 1,2 Udey, Mark C. 1; Affiliation:  1: Dermatology and  2: Experimental Immunology Branches, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jan1999, Vol. 112 Issue 1, p102; Subject Term: SKIN; Subject Term: LANGERHANS cells; Subject Term: CONFOCAL microscopy; Subject Term: TRANSMISSION electron microscopy; Author-Supplied Keyword: adhesion; Author-Supplied Keyword: dendritic cell maturation; Author-Supplied Keyword: Langerhans cells; Number of Pages: 7p; Illustrations: 11 Black and White Photographs, 7 Diagrams; Document Type: Article
L3  - 10.1046/j.1523-1747.1999.00475.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5167133&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107092247
T1  - Breast cancer and BSE knowledge among Brazilian women: implications for breast health education.
AU  - Phillips JM
AU  - Mamede MV
Y1  - 1999/01//
N1  - Accession Number: 107092247. Language: English. Entry Date: 20000301. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Champion's Breast Cancer and BSE Knowledge Scale. Grant Information: University of Illinois College of Nursing's Minority International Training Grant Program, and the NIH, Fogarty International Center Grant No. TW 0057. NLM UID: 9509701. 
KW  - Breast Neoplasms
KW  - Health Knowledge
KW  - Breast Self-Examination
KW  - Funding Source
KW  - Convenience Sample
KW  - Brazil
KW  - Scales
KW  - Descriptive Statistics
KW  - Descriptive Research
KW  - Health Knowledge -- Evaluation
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 34
EP  - 39
JO  - Journal of Multicultural Nursing & Health (JMCNH)
JF  - Journal of Multicultural Nursing & Health (JMCNH)
JA  - J MULTICULT NURS HEALTH
VL  - 5
IS  - 2
CY  - Houston, Texas
PB  - Riley Publications
AB  - OBJECTIVES: The purpose of this study was to assess knowledge related to breast cancer and breast self-examination (BSE) among Brazilian women; an understudied area of nursing research in Brazil. METHODS: Face-to-face interviews were conducted with 65 Brazilian women age 24-83 without a known history of breast cancer. RESULTS: The majority (80-90%) of subjects were more likely to correctly answer items assessing the need for medical attention than any other subset of items. Few subjects correctly answered items assessing breast changes, breast cancer etiologic/risk factors, and BSE technique. CONCLUSIONS: Results highlight the need for breast health education with an emphasis on breast cancer in general and BSE specifically for Brazilian women. There remains a need to develop more detailed, reliable and culturally appropriate instruments for assessing breast health among this population.
SN  - 1526-8233
AD  - Program Director, National Institute of Nursing Research, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107092247&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Shah, Jay P.
T1  - Dimensions of “Functional Status” in Trials or Wasting.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999/01//
VL  - 129
IS  - 1
M3  - Article
SP  - 279S
EP  - 281S
SN  - 00223166
N1  - Accession Number: 96710974; Shah, Jay P. 1; Affiliation:  1: Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland 20814; Source Info: Jan99, Vol. 129 Issue 1, p279S; Number of Pages: 3p; Illustrations: 2 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107163454
T1  - Observations. Does the mouth put the heart at risk?
AU  - Slavkin HC
Y1  - 1999/01//
N1  - Accession Number: 107163454. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; directories; pictorial. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Chronic Disease -- Complications
KW  - Mouth Diseases -- Complications
KW  - Mouth Diseases -- Physiopathology
KW  - Cardiovascular Diseases -- Complications
KW  - Periodontal Diseases -- Complications
KW  - Endocarditis, Bacterial -- Etiology
SP  - 109
EP  - 113
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 1
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - Director, National Institute of Dental and Craniofacial Research, 31 Center Dr, MSC 2290, Building 31, Room 2C39, Bethesda, MD 20892-2290
U2  - PMID: 9919040.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107163454&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Burns, D. N.;
AU  - Mofenson, L. M.;
T1  - Pediatric HIV-1 infection
CT  - Pediatric HIV-1 infection
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1999/01/01/
VL  - 354
IS  - Suppl 2
SP  - 1
EP  - 6
SN  - 00995355
AD  - Pediatr., Adolescent, and Maternal AIDS Branch, Natl. Inst. of Child Hlth. and Human Dev., NIH, 6100 Executive Blvd., Rm. 4B11, Bethesda, MD 20892-7510, USA Internet: db98d@nih.gov
N1  - Accession Number: 37-02970; Language: English; References: 60; Publication Type: Review; Journal Coden: LANCAO; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Ellen Katz Neumann
N2  - A review of the current status of human immunodeficiency virus-1 (HIV-1) infections in pediatric patients is presented, including routes of transmission, the pathogenesis of the virus, and the use of antiretroviral agents for the prevention and treatment of infection.
KW  - HIV infections--pediatrics--review;
KW  - Pediatrics--HIV infections--review;
KW  - Antiretroviral agents--HIV infections--pediatrics;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=37-02970&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107188769
T1  - Approach to therapy. The current state of infectious disease: a clinical perspective on antimicrobial resistance.
AU  - Shay LE
AU  - Freifeld AG
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188769. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Drug Resistance, Microbial
KW  - Education, Continuing (Credit)
KW  - Primary Health Care
KW  - Drug Administration
KW  - Preventive Health Care
KW  - Epidemiology
KW  - Antibiotics, Lactam
KW  - Antibiotics, Macrolide
KW  - Antiinfective Agents, Fluoroquinolone
KW  - Methicillin Resistance
KW  - Vancomycin Resistance
SP  - 1
EP  - 18
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - National Institutes of Health, National Cancer Institute, BID 10 12N226, 9000 Rockville Pike, Bethesda, MD 20892
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107188769&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107188770
T1  - Pharmacology update. Antibiotics in primary care: focus on fluoroquinolones and other new and investigational antimicrobial agents.
AU  - Pau AK
AU  - Slone RB
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188770. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Antiinfective Agents, Fluoroquinolone
KW  - Antiinfective Agents, Fluoroquinolone -- Therapeutic Use
KW  - Antiinfective Agents, Fluoroquinolone -- Administration and Dosage
KW  - Antiinfective Agents, Fluoroquinolone -- Adverse Effects
KW  - Antiinfective Agents, Fluoroquinolone -- Economics
KW  - Administration, Inhalation
KW  - Tobramycin -- Administration and Dosage
KW  - Tobramycin -- Therapeutic Use
KW  - Pseudomonas Infections -- Drug Therapy
KW  - Pharmacokinetics
KW  - Drug Interactions
KW  - Drugs, Investigational
KW  - Antibiotics -- Therapeutic Use
KW  - Child
KW  - Adult
SP  - 39
EP  - 54
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - National Institutes of Health, Warren G. Magnuson Clinical Center, Building 10, Room 1N257, 10 Center Drive, MSC 1196, Bethesda, MD 20892-1196
U2  - PMID: 10214201.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107188770&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107188773
T1  - Protocols. Treatment of pulmonary tuberculosis.
AU  - LeMasters CZ
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188773. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; protocol; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Tuberculosis, Pulmonary -- Diagnosis
KW  - Tuberculosis, Pulmonary -- Drug Therapy
KW  - Antitubercular Agents -- Administration and Dosage
KW  - Tuberculosis, Pulmonary -- Etiology
KW  - Tuberculosis, Pulmonary -- Prevention and Control
KW  - Tuberculosis, Pulmonary -- Education
KW  - Drug Toxicity -- Prevention and Control
KW  - Patient Education
KW  - Mycobacterium Tuberculosis
SP  - 55
EP  - 58
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Medicine Branch of the National Cancer Institute, The National Institutes of Health, 10 Center Drive, 12N226, Bethesda, MD 20892
U2  - PMID: 10214202.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107188773&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107188771
T1  - Cellulitis.
AU  - Anderson VL
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188771. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; protocol. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Cellulitis -- Diagnosis
KW  - Cellulitis -- Drug Therapy
KW  - Antibiotics -- Administration and Dosage
KW  - Cellulitis -- Etiology
KW  - Cellulitis -- Education
KW  - Cellulitis -- Prevention and Control
KW  - Diagnosis, Differential
KW  - Patient Education
SP  - 59
EP  - 64
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr., MSC 1826, Bldg. 10, Rm. 11N113, Bethesda, MD 20896-1886
U2  - PMID: 10214203.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107188771&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107188772
T1  - What I need to know about infections and antibiotics.
AU  - Shay LE
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188772. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Bacterial Infections
KW  - Virus Diseases
KW  - Antibiotics -- Therapeutic Use
SP  - 70
EP  - 71
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - National Cancer Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 10214205.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107188772&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107188778
T1  - Lower respiratory tract infections in the pediatric patient.
AU  - Walsek C
AU  - Boler AM
AU  - Zwerski S
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188778. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; protocol; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Respiratory Tract Infections -- In Infancy and Childhood
KW  - Diagnosis, Differential
KW  - Physical Examination
KW  - Epiglottitis -- Epidemiology -- In Infancy and Childhood
KW  - Epiglottitis -- Diagnosis -- In Infancy and Childhood
KW  - Epiglottitis -- Therapy -- In Infancy and Childhood
KW  - Bronchitis -- Epidemiology
KW  - Bronchitis -- Etiology
KW  - Bronchitis -- Diagnosis
KW  - Croup -- Epidemiology
KW  - Croup -- Etiology
KW  - Croup -- Diagnosis
KW  - Croup -- Therapy
KW  - Pneumonia -- Etiology -- In Infancy and Childhood
KW  - Pneumonia -- Diagnosis -- In Infancy and Childhood
KW  - Pneumonia -- Therapy -- In Infancy and Childhood
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Child
SP  - 93
EP  - 107
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - HIV and AIDS Malignancy Branch, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892
U2  - PMID: 10214209.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107188779
T1  - Infectious disease emergencies in primary care.
AU  - Kwitkowski VE
AU  - Demko SG
Y1  - 1999/01//1999 Jan-Feb
N1  - Accession Number: 107188779. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; algorithm; case study; review; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Communicable Diseases -- Diagnosis
KW  - Communicable Diseases -- Therapy
KW  - Emergency Care
KW  - Meningitis, Bacterial -- Diagnosis
KW  - Meningitis, Bacterial -- Symptoms
KW  - Meningitis, Bacterial -- Drug Therapy
KW  - Rocky Mountain Spotted Fever -- Diagnosis
KW  - Rocky Mountain Spotted Fever -- Symptoms
KW  - Rocky Mountain Spotted Fever -- Drug Therapy
KW  - Ehrlichiosis -- Diagnosis
KW  - Ehrlichiosis -- Drug Therapy
KW  - Meningococcal Infections -- Diagnosis
KW  - Meningococcal Infections -- Drug Therapy
KW  - Soft Tissue Infections -- Diagnosis
KW  - Fasciitis, Necrotizing -- Diagnosis
KW  - Fasciitis, Necrotizing -- Therapy
KW  - Toxic Shock Syndrome -- Diagnosis
KW  - Toxic Shock Syndrome -- Therapy
KW  - Food Poisoning -- Diagnosis
KW  - Food Poisoning -- Therapy
KW  - Escherichia Coli Infections -- Diagnosis
KW  - Escherichia Coli Infections -- Therapy
KW  - Coccidiosis -- Diagnosis
KW  - Coccidiosis -- Drug Therapy
KW  - Endocarditis, Bacterial -- Diagnosis
KW  - Endocarditis, Bacterial -- Drug Therapy
KW  - Endocarditis, Bacterial -- Etiology
KW  - Child
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
SP  - 108
EP  - 125
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 1
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
U2  - PMID: 10214210.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Grave, G.D.
AU  - Giacoia, G.P.
AU  - Yaffe, S.J.
T1  - Why Do We Need a New Journal in Paediatric Pharmacology?
JO  - Pediatric Drugs
JF  - Pediatric Drugs
Y1  - 1999/01//Jan-Mar1999
VL  - 1
IS  - 1
M3  - Article
SP  - 3
EP  - 5
PB  - Springer Science & Business Media B.V.
SN  - 11745878
AB  - Today’s issue marks the birth of Paediatric Drugs Does a world already awash in journals old and new need yet another? The editors wrestled with that question during the journal’s gestation and believe the answer to be a decided yes.When asked of what use is electricity, Benjamin Franklin responded ‘Of what use is a newborn baby?’ Paediatric Drugs is as full of potential as a neonate, but to survive in the competitive world, to attain greatness and to compete for its share of readership and subscriptions, this neonate will need the succour and patronage of its authors and readers. To compete for readership, Paediatric Drugs will need to offer significant articles, and to attract worthy submissions the journal will need to offer a significant readership.Historically it should be noted that 2 journals devoted to paediatric drugs preceded this launch. The first, Paediatric Pharmacology, initiated in the 1970s by Alan Liss, Inc., met its demise when the publisher sold his corporate entity. The second journal, Developmental Pharmacology and Therapeutics, was published at the same time as Paediatric Pharmacology by S. Karger. However, it lost its identity several years ago when it was incorporated into Biology of the Neonate (also published by S. Karger). At the present time there is no publication devoted to paediatric therapeutics.Allan Shaughnessey, Pharm.D., noted at a recent meeting on evidence-based medicine sponsored by the US Agency for Health Care Policy and Research that only about 3% of articles in medical journals are worth the investment of time required to read them. He added that most articles focus on disease processes rather than patient-oriented therapy and evidentiary medicine. Even when journal articles do address therapy, they often omit information about the effect of an intervention on a patient’s mortality, morbidity or quality of life. Paediatric Drugs needs to face this issue squarely and must offer... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Pediatric Drugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PEDIATRICS
KW  - PERIODICALS
KW  - Adolescents
KW  - Children
KW  - Infants
KW  - Labelling
KW  - Medical-journals
N1  - Accession Number: 6886269; Grave, G.D. 1 Giacoia, G.P. 2 Yaffe, S.J. 3; Affiliation:  1: Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children,National Institute of Child Health and Human Development, Bethesda, Maryland, USA  2: Pediatric Pharmacology Research Unit Network, Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Bethesda, Maryland, USA  3: Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Bethesda, Maryland, USA; Source Info: Jan-Mar1999, Vol. 1 Issue 1, p3; Subject Term: PEDIATRICS; Subject Term: PERIODICALS; Author-Supplied Keyword: Adolescents; Author-Supplied Keyword: Children; Author-Supplied Keyword: Infants; Author-Supplied Keyword: Labelling; Author-Supplied Keyword: Medical-journals; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
AU  - Shurtleff, David
AD  - National Institute on Drug Abuse, National Institutes of Health
A2  - Chaloupka, Frank J.
T1  - Illicit Drug Use: Comment
T2  - The economic analysis of substance use and abuse: An integration of econometric and behavioral economic research
PB  - NBER Conference Report series.
PB  - Chicago and London:
PB  - University of Chicago Press
Y1  - 1999///
SP  - 180
EP  - 184
N1  - Accession Number: 0570610 Partial authors List; ; Reviewed Book ISBN: 0-226-10047-2; ; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200107
KW  - Fertility; Family Planning; Child Care; Children; Youth          J13
KW  - Consumer Economics: Empirical Analysis          D12
KW  - Health Production          I12
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DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Peters, Jeffrey M.
AU  - Narotsky, Michael G.
AU  - Elizondo, Guillermo
AU  - Fernandez-Salguero, Pedro M.
AU  - Gonzalez, Frank J.
AU  - Abbott, Barbara D.
T1  - Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/01//
VL  - 47
IS  - 1
M3  - Article
SP  - 86
EP  - 92
PB  - Oxford University Press / USA
SN  - 10966080
AB  - The aryl hydrocarbon receptor (AhR) mediates many of the biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and transcriptional activation of genes encoding a number of xenobiotic metabolizing enzymes. Prenatal exposure of mice to TCDD causes severe alterations in embryo and fetal development, including hydronephrosis and cleft palate. However, the mechanisms underlying these effects are unclear. In this work, the teratogenicity of TCDD in AhR-null mice was evaluated to determine if this effect is mediated by the AhR. Homozygous wild-type (+/+) or AhR-null (-/-) female mice were mated with males of the same genotype overnight. On gestation day (GD)-10, mice were intubated orally with either corn oil (vehicle control) or 25 μg/kg TCDD. Fetuses were examined on GD18 for visceral and skeletal alterations. For non-TCDD-exposed litters, all developmental endpoints were comparable between genotypes, with the exception of a lower incidence of large interfrontal bones in (-/-) mice. For TCDD-exposed litters, (+/+) fetuses had a significantly greater incidence of cleft palate, hydronephrosis, small kidneys, tortuous ureters and greater dilation of the renal pelves and ureters compared to (-/-) fetuses. Interestingly, an increased resorption rate was observed in (-/-) fetuses exposed to TCDD. Results from this work demonstrate that fetal development per se is generally unaffected by the absence of the AhR or that other genes may have compensated for the loss of the AhR. More importantly, these data indicate that the AhR mediates TCDD-induced teratogenicity. Further, since a higher percentage of resorptions was observed in (-/-) litters from TCDD-treated dams, it is possible that AhR-independent mechanisms contribute to TCDD-induced developmental toxicity. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Tetrachlorodibenzodioxin
KW  - Hydrocarbons
KW  - Xenobiotics
KW  - Teratogenesis
KW  - Genes
KW  - Mice as laboratory animals
KW  - Embryos
KW  - Fetal development
KW  - 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
KW  - 2;3;7;8-tetrachlorodibenzo-p-dioxin (TCDD)
KW  - aryl hydrocarbon receptor (AhR)
KW  - developmental toxicity
KW  - teratogenicity
KW  - teratogenicity.
N1  - Accession Number: 44611614; Peters, Jeffrey M. 1; Narotsky, Michael G. 2; Elizondo, Guillermo 1; Fernandez-Salguero, Pedro M. 1; Gonzalez, Frank J. 1; Abbott, Barbara D. 2; Affiliations: 1: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; 2: Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711; Issue Info: Jan1999, Vol. 47 Issue 1, p86; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Hydrocarbons; Thesaurus Term: Xenobiotics; Subject Term: Teratogenesis; Subject Term: Genes; Subject Term: Mice as laboratory animals; Subject Term: Embryos; Subject Term: Fetal development; Author-Supplied Keyword: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); Author-Supplied Keyword: 2;3;7;8-tetrachlorodibenzo-p-dioxin (TCDD); Author-Supplied Keyword: aryl hydrocarbon receptor (AhR); Author-Supplied Keyword: developmental toxicity; Author-Supplied Keyword: teratogenicity; Author-Supplied Keyword: teratogenicity.; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Garry, V.F.
AU  - Burroughs, B.
AU  - Tarone, R.
AU  - Kesner, J.S.
T1  - Herbicides and adjuvants: an evolving view.
JO  - Toxicology & Industrial Health
JF  - Toxicology & Industrial Health
Y1  - 1999/01//
VL  - 15
IS  - 1/2
M3  - Article
SP  - 159
EP  - 167
PB  - Sage Publications, Ltd.
SN  - 07482337
AB  - The present report examines the in vitro genotoxicity (micronucleus assay) of herbicides and adjuvants and reports on an in vivo human study on potential endocrine effects of pesticides, including herbicides. Adjuvants are used in conjunction with 2,4-dichlorophenoxy acetic acid (2,4-D) and other herbicides. Earlier pesticide applier survey results (n=709) show that 59% of the applicators used adjuvants, and the majority of this group used paraffinic oils and/or surfactant mixtures. As a beginning effort to explore the role of adjuvants and herbicides in hormonally based reproductive effects, a prospective, controlled study was performed to analyze blood specimens from three different exposure groups (applicators using herbicides only; applicators using both herbicides and insecticides; and applicators using fumigants in addition to herbicides and insecticides; and a control group composed of other agricultural workers including organic farmers). The applicators and controls were age- and smoking-matched. Study subjects (n=78) were tested before, during, and after completion of pesticide application season for the effects of pesticide products on hormone levels in the bloodstream. Of the applicator exposure groups examined, only the herbicide group showed significant endocrinologic differences from controls. Free testosterone levels were significantly elevated in post-season measurements (p=0.032), and follicle-stimulating hormone (FSH) was significantly decreased at the height of the season (p=0.016) and in the post-season (p=0.010) as compared to controls. These endocrinologic findings are discussed in terms of their possible relationship to potential endocrine effects of herbicides, herbicide contaminants, and adjuvants. In vitro genotoxicity examination compared four different commercially available surfactant mixtures with 12 different commercial herbicide products, including six different chlorophenoxy herbicides. Only one herbicide yielded a significant dose–response curve. All four adjuvants showed positive dose–response effects. These preliminary data suggest that adjuvants are not inert but are toxicologically active components added to herbicide mixtures. Whether adjuvant toxicant effects are additive or are independent of herbicide effects is poorly understood. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HERBICIDES
KW  - IMMUNOLOGICAL adjuvants
KW  - GENETIC toxicology
KW  - PESTICIDES
KW  - adjuvants
KW  - herbicides
KW  - hormone analysis
KW  - human study
KW  - Micronucleus assay
N1  - Accession Number: 4745647; Garry, V.F. 1 Burroughs, B. 1 Tarone, R. 2 Kesner, J.S. 3; Affiliation:  1: University of Minnesota, Environmental Medicine and Pathology Program, Minneapolis, Minnesota  2: National Cancer Institute, Epidemiology and Biostatistics Program, Bethesda, Maryland  3: National Institute for Occupational Safety and Health, Experimental Toxicology Branch, Cincinnati, Ohio; Source Info: 1999, Vol. 15 Issue 1/2, p159; Subject Term: HERBICIDES; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: GENETIC toxicology; Subject Term: PESTICIDES; Author-Supplied Keyword: adjuvants; Author-Supplied Keyword: herbicides; Author-Supplied Keyword: hormone analysis; Author-Supplied Keyword: human study; Author-Supplied Keyword: Micronucleus assay; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1999-11714-002
AN  - 1999-11714-002
AU  - Tomita, Takuro
AU  - Agari, Ichiro
T1  - Development of Food Choice Questionnaire New Version.
JF  - Japanese Journal of Health Psychology
JO  - Japanese Journal of Health Psychology
Y1  - 1999///
VL  - 12
IS  - 1
SP  - 17
EP  - 27
CY  - Japan
PB  - Waseda University/Faculty of Literature
SN  - 0917-3323
SN  - 2187-5529
N1  - Accession Number: 1999-11714-002. Partial author list: First Author & Affiliation: Tomita, Takuro; National Institute of Mental Health, Dept of Sociocultural Environmental Research, Ichikawa, Japan. Release Date: 20000501. Correction Date: 20160509. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: Japanese. Major Descriptor: Food Preferences; Health Attitudes; Questionnaires; Test Construction. Minor Descriptor: Ingestion; Test Reliability. Classification: Neuropsychological Assessment (2225); Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study. Page Count: 11. Issue Publication Date: 1999. 
AB  - Examined the perceived motives of food choice with the Food Choice Questionnaire—New Version (FCQ-N) and confirmation of test–retest reliability and internal consistency of FCQ-N. Ss in Exp 1 were 241 male and 273 female adults (mean age 36.5 yrs) and 132 male and 295 female college students (mean age 20.5 yrs) in Japan. Ss were administered FCQ-N in 1996 & 1997. Exploratory factor analysis yielded 4 factors: Nutrition and Health, Weight Control, Convenience, and Sensory Appeal. Relationships between the subscales and dietary habits were analyzed. Ss in Exp 2 were 24 male and 118 female college students (mean age 20.2 yrs) in Japan. Ss were administered FCQ-N, Japanese version of the Health Locus of Control Scales (JHLC), and the Dutch Eating Behavior Questionnaire (DEBQ) in 1997. Ss' heights and weights were asked. Relationships between JHLC, DEBQ and FCQ-N, and relationships between Body Mass Index (BMI) and FCQ-N were analyzed. Convergent validity was examined by testing links between FCQ-N subscales and dietary restraint and internal HLC. The results indicated initial evidence of the reliability and validity of FCQ-N and intensified significance of measuring and addressing the motives in health counseling and nutrition education. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - development & reliability & internal consistency of Food Choice Questionnaire
KW  - assessment of food choice motives & health locus of control & eating behavior
KW  - adults (mean ages 20.5 & 36.5 yrs)
KW  - 1999
KW  - Food Preferences
KW  - Health Attitudes
KW  - Questionnaires
KW  - Test Construction
KW  - Ingestion
KW  - Test Reliability
KW  - 1999
DO  - 10.11560/jahp.12.1_17
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-09303-004
AN  - 2006-09303-004
AU  - Pant, Manish K.
AU  - Veeranna
AU  - Amin, Niranjana D.
AU  - Amin, Nivee
AU  - Pant, Harish C.
T1  - Phosphorylation Activity in the Alzheimer's Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau in Vitro.
JF  - Journal of Alzheimer's Disease
JO  - Journal of Alzheimer's Disease
JA  - J Alzheimers Dis
Y1  - 1999///
VL  - 1
IS  - 3
SP  - 169
EP  - 182
CY  - Netherlands
PB  - IOS Press
SN  - 1387-2877
SN  - 1875-8908
AD  - Pant, Harish C., Laboratory of Neurochemistry, NINDS/NIH, Bldg. 36 Rm. 4D20, Bethesda, MD, US, 20892
N1  - Accession Number: 2006-09303-004. PMID: 12214002 Partial author list: First Author & Affiliation: Pant, Manish K.; Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20060821. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alzheimer's Disease; Neuropathology; Phosphorylases; Proteins; Phosphorylation. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 1999. 
AB  - One of the hallmarks of Alzheimer's Disease is the presence of abundant neurofibrillary tangles (NFTs) in the brains of affected individuals. Hyperphosphorylated tau is a major component of paired helical filaments (PHFs) in NFTs. Tau is a neuronal microtubule associated protein found primarily in axons. Normal tau promotes tubulin polymerization and stabilizes microtubule (MT) structures, whereas hyperphosphorylated tau reduces its affinity for MTs and destabilizes MTstructures. This results in the disruption of vital cellular processes (e.g. axonal transport) and leads to the degeneration of affected neurons. Processes leading to the hyperphosphorylation of tau and formation of neurofibrillary lesions in Alzheimer's Disease (AD) brains are not understood. Phosphorylation of a substrate molecule like tau depends upon the equilibrium between kinase and phosphatase activities and the availability of their substrate molecules in a given system. Therefore, to understand the relative roles of kinase and phosphatase activities, we studied the long-term kinetics of phosphorylation in AD and control brain extracts in the presence and absence of the phosphatase inhibitor okadaic acid (OA) using histone, casein and bacterially expressed tau as exogenous substrates. It was found that both kinase and phosphatase activities were higher in AD compared to control brains. Surprisingly, between 18 and 24 hours, there was a robust increase in phosphorylation of endogenous proteins in the brain extracts only when bacterially expressed tau was present in the phosphorylation reaction mixture. This pattern of phosphorylation activity was unaffected by OA. Significant difference in the phosphorylation of tau isoforms was also seen during this period. These data suggest that the expression and differential phosphorylation of certain tau isoforms may be responsible for the robust increase in phosphorylation and may play an important role in Alzheimer's pathology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - phosphorylation
KW  - Alzheimer's disease
KW  - microtubule-associated protein tau
KW  - neuropathology
KW  - 1999
KW  - Alzheimer's Disease
KW  - Neuropathology
KW  - Phosphorylases
KW  - Proteins
KW  - Phosphorylation
KW  - 1999
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UR  - hcp@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-14218-003
AN  - 2004-14218-003
AU  - Kitamura, Toshinori
AU  - Sugawara, M.
AU  - Shima, S.
AU  - Toda, M. A.
T1  - Childhood adversities and depression: II. Parental loss, rearing, and symptom profile of antenatal depression.
JF  - Archives of Women's Mental Health
JO  - Archives of Women's Mental Health
JA  - Arch Womens Ment Health
Y1  - 1999///
VL  - 1
IS  - 4
SP  - 175
EP  - 182
CY  - Germany
PB  - Springer
SN  - 1434-1816
SN  - 1435-1102
AD  - Kitamura, Toshinori, Department of Sociocultural Environmental Research, National Institute of Mental Health, 1-7-3 Konodai, Ichikawa, Chiba, Japan, 272
N1  - Accession Number: 2004-14218-003. Partial author list: First Author & Affiliation: Kitamura, Toshinori; National Institute of Mental Health, Chiba, Japan. Release Date: 20040830. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Major Depression; Parent Child Relations; Parental Death; Pregnancy; Prenatal Care. Minor Descriptor: Human Females. Classification: Affective Disorders (3211). Population: Human (10); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Zung's Self Rating Depression Scale; Parental Bonding Instrument DOI: 10.1037/t06510-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: 1999. 
AB  - Among a total of 1,329 pregnant women, neither early loss experience by death or by separation before the age of 16 was related to any of the three depressive symptom constellations derived from Zung's Self-rating Depression Scale - Dysphoric Mood, Cognitive Disturbance, and Poor Concentration. Paternal and maternal low care and overprotection scores of the Parental Bonding Instrument, a measure of perceived rearing, had main effects on the Cognitive Disturbance and Poor Concentration scores, with significant interaction of the two predictors; Dysphoric Mood was also linked to maternal overprotection. These findings suggest that perceived parenting is a predictor of two specific symptom constellations of antenatal depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - antenatal depression
KW  - dysphoric mood
KW  - cognitive disturbance
KW  - poor concentration
KW  - childhood adversities
KW  - parental loss
KW  - rearing
KW  - pregnancy
KW  - depressive symptoms
KW  - perceived parenting
KW  - 1999
KW  - Major Depression
KW  - Parent Child Relations
KW  - Parental Death
KW  - Pregnancy
KW  - Prenatal Care
KW  - Human Females
KW  - 1999
DO  - 10.1007/s007370050025
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-14218-003&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2005-09772-008
AN  - 2005-09772-008
AU  - Elkashef, Ahmed M.
AU  - Wyatt, Richard Jed
T1  - Tardive Dyskinesia: Possible Involvement of Free Radicals and Treatment With Vitamin E.
JF  - Schizophrenia Bulletin
JO  - Schizophrenia Bulletin
JA  - Schizophr Bull
Y1  - 1999///
VL  - 25
IS  - 4
SP  - 731
EP  - 740
CY  - US
PB  - National Institute of Mental Health
SN  - 0586-7614
SN  - 1745-1701
AD  - Elkashef, Ahmed M., Medications Development Division, NIDA, 6001 Executive Blvd., Rm. 4123, MSC 9551, Bethesda, MD, US, 20892-9551
N1  - Accession Number: 2005-09772-008. PMID: 10667743 Partial author list: First Author & Affiliation: Elkashef, Ahmed M.; National Institute on Drug Abuse, MD, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Tardive Dyskinesia; Vitamin Therapy. Minor Descriptor: Drug Therapy; Neuroleptic Drugs; Vitamins. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 10. Issue Publication Date: 1999. 
AB  - A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - tardive dyskinesia
KW  - vitamin E
KW  - neuroleptic treatment
KW  - 1999
KW  - Tardive Dyskinesia
KW  - Vitamin Therapy
KW  - Drug Therapy
KW  - Neuroleptic Drugs
KW  - Vitamins
KW  - 1999
DO  - 10.1093/oxfordjournals.schbul.a033414
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09772-008&site=ehost-live&scope=site
UR  - ae8a@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42403-026
AN  - 2015-42403-026
AU  - Chandross, Karen J.
AU  - Cohen, Rick I.
AU  - Paras, Peter Jr.
AU  - Gravel, Michel
AU  - Braun, Peter E.
AU  - Hudson, Lynn D.
T1  - Identification and characterization of early glial progenitors using a transgenic selection strategy.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/01//
VL  - 19
IS  - 2
SP  - 759
EP  - 774
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Chandross, Karen J., National Institutes of Health, National Institute for Neurological Diseases and Stroke, Laboratory of Developmental Neurogenetics, Building 36, Room 5D21, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-42403-026. PMID: 9880596 Partial author list: First Author & Affiliation: Chandross, Karen J.; National Institutes of Health, National Institute for Neurological Diseases and Stroke, Laboratory of Developmental Neurogenetics, Bethesda, MD, US. Release Date: 20160225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cohen, Rick I. Major Descriptor: Neuroglia; Oligodendrocytes; Schwann Cells. Minor Descriptor: Mice; Nucleotides; White Matter; Phosphodiesterase. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Jan, 1999. Publication History: Accepted Date: Oct 26, 1998; Revised Date: Sep 25, 1998; First Submitted Date: Aug 25, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - To define the spatiotemporal development of and simultaneously select for oligodendrocytes (OLs) and Schwann cells (SCs), transgenic mice were generated that expressed a bacterial β-galactosidase (β-gal) and neomycin phosphotransferase fusion protein (βgeo) under the control of murine 2′3′-cyclic nucleotide 3′-phosphodiesterase (muCNP) promoters I and II. Transgenic β-gal activity was detected at embryonic day 12.5 in the ventral region of the rhombencephalon and spinal cord and in the neural crest. When cells from the rhombencephalon were cultured in the presence of G418, surviving cells differentiated into OLs, indicating that during development this brain region provides one source of OL progenitors. Postnatally, robust β-gal activity was localized to OLs throughout the brain and was absent from astrocytes, neurons, and microglia or monocytes. In the sciatic nerve b-gal activity was localized exclusively to SCs. Cultures from postnatal day 10 brain or sciatic nerve were grown in the presence of G418, and within 8–9 d exposure to antibiotic, 99% of all surviving cells were β-gal-positive OLs or SCs. These studies demonstrate that the muCNP-βgeo transgenic mice are useful for identifying OLs and SCs beginning at early stages of the glial cell lineage and throughout their development. This novel approach definitively establishes that the β-gal-positive cells identified in vivo are glial progenitors, as defined by their ability to survive antibiotic selection and differentiate into OLs or SCs in vitro. Moreover, this experimental paradigm facilitates the rapid and efficient selection of pure populations of mouse OLs and SCs and further underscores the use of cell-specific promoters in the purification of distinct cell types. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - 2' 3'-cyclic nucleotide 3'-phosphodiesterase
KW  - β-galactosidase
KW  - CNS
KW  - development
KW  - glia
KW  - neomycin resistance
KW  - peripheral nervous system
KW  - selection
KW  - tissue culture
KW  - 1999
KW  - Neuroglia
KW  - Oligodendrocytes
KW  - Schwann Cells
KW  - Mice
KW  - Nucleotides
KW  - White Matter
KW  - Phosphodiesterase
KW  - 1999
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, US. Other Details: Intramural funds. Recipients: No recipient indicated
U1  - Sponsor: National Multiple Sclerosis Society. Grant: FG1197-A1. Recipients: Cohen, Rick I.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-42403-026&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42403-027
AN  - 2015-42403-027
AU  - Palko, Mary Ellen
AU  - Coppola, Vincenzo
AU  - Tessarollo, Lino
T1  - Evidence for a role of truncated trkC receptor isoforms in mouse development.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/01//
VL  - 19
IS  - 2
SP  - 775
EP  - 782
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Tessarollo, Lino, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD, US, 21702
N1  - Accession Number: 2015-42403-027. PMID: 9880597 Partial author list: First Author & Affiliation: Palko, Mary Ellen; Neural Development Group, Advanced Bioscience Laboratories-Basic Research Program, National Cancer Institute- Frederick Cancer Research and Development Center, Frederick, MD, US. Release Date: 20160225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Kinases; Tyrosine; Neurotrophic Factor. Minor Descriptor: Mice. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 1999. Publication History: Accepted Date: Oct 28, 1998; Revised Date: Oct 7, 1998; First Submitted Date: Jul 13, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - The trkC locus encodes several receptors for neurotrophin-3, including the well studied full-length tyrosine kinase isoform, in addition to receptor isoforms lacking the kinase active domain. TrkC receptors are widely expressed throughout mouse development in many different organs. To investigate the function of truncated receptors in vivo and to identify cell types that are biologically responsive to this gene product, we have overexpressed a physiological truncated trkC isoform in the mouse. Mice overexpressing this receptor develop to term but die in the first postnatal days. High levels of transgene expression result in severe developmental defects in the peripheral nervous system and in the heart. The severity of neuronal losses observed in these animals suggests that truncated receptors may act by sequestering neurotrophin, thus, closely relating this mouse model to the neurotrophin-3-deficient one. Lower levels of exogenous truncated receptor in transgenic mice result in a more modest phenotype and, in some neuronal populations, do not cause neural deficits. Taken together, these data suggest that truncated trkC receptor isoforms may have modulatory functions in development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - trkC
KW  - truncated receptor
KW  - development
KW  - neurotrophin
KW  - trk receptors
KW  - transgenic
KW  - 1999
KW  - Kinases
KW  - Tyrosine
KW  - Neurotrophic Factor
KW  - Mice
KW  - 1999
U1  - Sponsor: National Cancer Institute, Advanced Bioscience Laboratories, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-42403-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42403-036
AN  - 2015-42403-036
AU  - Drago, John
AU  - Padungchaichot, Poolpol
AU  - Wong, John Y. F.
AU  - Lawrence, Andrew J.
AU  - McManus, Julie F.
AU  - Sumarsono, Sony H.
AU  - Natoli, Anthony L.
AU  - Lakso, Merja
AU  - Wreford, Nigel
AU  - Westphal, Heiner
AU  - Kola, Ismail
AU  - Finkelstein, David I.
T1  - 'Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination': Correction.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/01//
VL  - 19
IS  - 2
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Drago, John, Neurosciences Group, Department of Anatomy, Monash University, Wellington Road, Clayton, VIC, Australia, 3168
N1  - Accession Number: 2015-42403-036. Partial author list: First Author & Affiliation: Drago, John; Neurosciences Group, Department of Anatomy, Monash University, Clayton, VIC, Australia. Release Date: 20160225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Basal Ganglia; Dopamine; Gene Expression; Neural Receptors. Minor Descriptor: Mice; Mutations. Classification: Neuropsychology & Neurology (2520). Issue Publication Date: Jan, 1999. 
AB  - Reports an error in 'Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination' by John Drago, Poolpol Padungchaichot, John Y. F. Wong, Andrew J. Lawrence, Julie F. McManus, Sony H. Sumarsono, Anthony L. Natoli, Merja Lakso, Nigel Wreford, Heiner Westphal, Ismail Kola and David I. Finkelstein (The Journal of Neuroscience, 1998[Dec], Vol 18[23], 9845-9857). In the original article, the figure citation on page 9847, left column, seventh line, should read (Fig. 3B). (The following abstract of the original article appeared in record [rid]2015-41750-026[/rid]). Idiopathic Parkinson’s disease involves the loss of midbrain dopaminergic neurons, resulting in the presynaptic breakdown of dopaminergic transmission in the striatum. Huntington’s disease and some neurodegenerative diseases with Parkinsonian features have postsynaptic defects caused by striatal cell death. Mice were generated in which an attenuated form of the diphtheria toxin gene (tox-176) was expressed exclusively in D1 dopamine receptor (D1R)-positive cells with the aim of determining the effect of this mutation on development of the basal ganglia and on the locomotor phenotype. Transgenic mice expressing Cre, a site-specific DNA recombinase, were crossed with a second line in which a transcriptionally silenced tox-176 gene was inserted into the D1R gene locus by homologous recombination. Young doubly transgenic mutant mice expressing the tox-176 gene displayed bradykinesia, dystonia, and had falls caused by myoclonic jerks. The mutant brain had evidence of apoptosis and reactive gliosis and, consistent with the D1R expression pattern, the striatum was reduced in volume, and the Islands of Calleja were absent. In contrast, the cortex was of normal thickness. D1Rs were not detectable in mutants by in situ hybridization or ligand autoradiography, whereas D2 dopamine receptor (D2R) mRNA and protein was present in the striatum. In addition, substance P and dynorphin, neuropeptides known to be expressed in D1R-positive striatonigral projection neurons were not detectable. Enkephalin, a marker found in D2-positive striatopallidal projection neurons was expressed in the mutant brain. The mutant represents a novel neurodegenerative disease model with a dramatic extrapyramidal phenotype. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - D1 dopamine receptor
KW  - basal ganglia
KW  - Cre recombinase
KW  - gene targeting
KW  - striatum
KW  - Parkinson’s disease
KW  - 1999
KW  - Basal Ganglia
KW  - Dopamine
KW  - Gene Expression
KW  - Neural Receptors
KW  - Mice
KW  - Mutations
KW  - 1999
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-42403-036&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - ABST
AU  - Stadtman, Earl R.
T1  - OXIDATIVE STRESS-PROVOKED PROTEIN OXIDATION.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S1
EP  - S1
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the research paper "Oxidative Stress-Provoked Protein Oxidation," which will be presented at the 30th American Society for Neurochemistry meeting to be held from March 14 to 17, 1999 in New Orleans, Louisiana. The research associates protein oxidation of reactive oxygen species (ROS) with various pathologic conditions. Level of carbonyl derivatives generated during interactions between ROS and protein indicate measure of oxidative stress-mediated damage.
KW  - OXIDATIVE stress
KW  - PROTEINS
KW  - OXIDATION
KW  - ACTIVE oxygen
KW  - NEUROCHEMISTRY
KW  - MEETINGS
KW  - ABSTRACTS
N1  - Accession Number: 23343390; Stadtman, Earl R. 1; Affiliation:  1: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-0342.; Source Info: Jan99 Supplement, Vol. 72, pS1; Subject Term: OXIDATIVE stress; Subject Term: PROTEINS; Subject Term: OXIDATION; Subject Term: ACTIVE oxygen; Subject Term: NEUROCHEMISTRY; Subject Term: MEETINGS; Subject Term: ABSTRACTS; Number of Pages: 1/4p; Document Type: Abstract
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23343390&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Williams, Wesley M.
AU  - Stadtman, Earl R.
T1  - DETECTION OF 4-HYDROXY-2-NONENAL (HNE) IN CEREBRAL MICROVESSELS OF C57BL/6J MICE AS A FUNCTION OF AGE.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S29
EP  - S29
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the paper "Detection of 4-Hydroxy-2-Nonenal (HNE) in Cerebral Microvessels of C57BL/6J Mice As a Function of Age," which will be presented at the 30th Annual Meeting of the American Society for Neurochemistry to be held in New Orleans, Louisiana from March 14-17, 1999. The paper suggests that the peroxidation of polyunsaturated fatty acids can reduce levels of these fatty acids in the cerebral microvessels of aged mice.
KW  - UNSATURATED fatty acids
KW  - FATTY acids
KW  - MICE as laboratory animals
KW  - PEROXIDATION
KW  - ABSTRACTS
KW  - NEW Orleans (La.)
KW  - LOUISIANA
N1  - Accession Number: 23343503; Williams, Wesley M. 1 Stadtman, Earl R. 1; Affiliation:  1: Laboratory of Biochemistry National Heart, Lung and Blood Institute, Bethesda, MD 20892.; Source Info: Jan99 Supplement, Vol. 72, pS29; Subject Term: UNSATURATED fatty acids; Subject Term: FATTY acids; Subject Term: MICE as laboratory animals; Subject Term: PEROXIDATION; Subject Term: ABSTRACTS; Subject Term: NEW Orleans (La.); Subject Term: LOUISIANA; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1/4p; Document Type: Abstract
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23343503&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Foley, Timothy D.
T1  - 4-HYDROXYNONENAL INHIBITS SYNAPTIC PLASMA MEMBRANE ECTO-ATPase ACTIVITY.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S33
EP  - S33
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents the abstract of the paper "4-Hydroxynonenal Inhibits Synaptic Plasma Membrane Ecto-ATPase Activity." The paper will be presented at the 30th meeting of the American Society for Neurochemistry which is scheduled to be held from March 14-17, 1999 in New Orleans, Louisiana. The paper proposes that the inhibition of ecto-ATPase activity by 4-Hydroxynonenal increases the oxidative stress which may give rise to excitatory synaptic transmission and excitotoxicity.
KW  - NEUROCHEMISTRY
KW  - CONFERENCES & conventions
KW  - ADENOSINE triphosphatase
KW  - CELL membranes
KW  - OXIDATIVE stress
KW  - NEURAL transmission
KW  - ABSTRACTS
N1  - Accession Number: 23343520; Foley, Timothy D. 1; Affiliation:  1: National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD.; Source Info: Jan99 Supplement, Vol. 72, pS33; Subject Term: NEUROCHEMISTRY; Subject Term: CONFERENCES & conventions; Subject Term: ADENOSINE triphosphatase; Subject Term: CELL membranes; Subject Term: OXIDATIVE stress; Subject Term: NEURAL transmission; Subject Term: ABSTRACTS; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 1/4p; Document Type: Abstract
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23343520&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Rapoport, S. I.
T1  - MEASURING DYNAMICS OF BRAIN PHOSPHOLIPID METABOLISM IN VIVO: RELATION TO SIGNALING AND NEUROPLASTICITY.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S48
EP  - S48
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the study " Measuring Dynamics of Brain Phospholipid Metabolism In Vivo: Relation to Signaling and Neuroplasticity," by S.I. Rapoport, which will be presented at the 30th annual meeting of the American Society for Neurochemistry to be held from March 14-17, 1999 in New Orleans, Louisiana. The study states that the inclusion of label into phospholipids is quick and is independent of brain blood flow.
KW  - NEUROPLASTICITY
KW  - PHOSPHOLIPIDS
KW  - BRAIN microdialysis
KW  - BRAIN chemistry
KW  - HEMODYNAMICS
KW  - BLOOD flow
KW  - ABSTRACTS
N1  - Accession Number: 23343578; Rapoport, S. I. 1; Affiliation:  1: Laboratory of Neurosciences, National Institute on Aging, NIH, Bethesda, Maryland USA 20892.; Source Info: Jan99 Supplement, Vol. 72, pS48; Subject Term: NEUROPLASTICITY; Subject Term: PHOSPHOLIPIDS; Subject Term: BRAIN microdialysis; Subject Term: BRAIN chemistry; Subject Term: HEMODYNAMICS; Subject Term: BLOOD flow; Subject Term: ABSTRACTS; Number of Pages: 1/4p; Document Type: Abstract
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23343578&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Contraas, M. A.
AU  - Greiner, R. S.
AU  - Chang, M. C. J.
AU  - Myers, C.
AU  - Bell, J. M.
AU  - Salem, Jr., N.
AU  - Rapoport, S. J.
T1  - α-LINOLENIC ACID DEPRIVATION ALTERS THE IN VIVO TURNOVER OF DOCOSAHEXAENOIC ACID IN RAT BRAIN PHOSPHOLIPIDS.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S65
EP  - S65
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the paper "α Linolenic Acid Deprivation Alters the in Vivo Turnover of Docosahexaenoic Acid in Rat Brain Phospholipids," which will be presented at the 30th Annual Meeting of the American Society for Neurochemistry to be held from March 14-17, 1999 in New Orleans, Louisiana. The study suggests that the turnover of docosahexaenoic acid in brain phospholipids, mostly in phosphatidyl ethanolamine, is increased by α -Linolenic Acid deprivation.
KW  - LINOLENIC acids
KW  - ESSENTIAL fatty acids
KW  - PHOSPHOLIPIDS
KW  - DOCOSAHEXAENOIC acid
KW  - CONFERENCES & conventions
KW  - ASSOCIATIONS, institutions, etc.
KW  - ABSTRACTS
N1  - Accession Number: 23343648; Contraas, M. A. 1 Greiner, R. S. 2 Chang, M. C. J. 1 Myers, C. 1 Bell, J. M. 1 Salem, Jr., N. 2 Rapoport, S. J. 1; Affiliation:  1: Lab. Neurosciences, NIA, National Institutes of Health, Bethesda, MD, 20892.  2: Lab. Membrane Biophysics and Biochemistry, NIAAA, National Institutes of Health, Bethesda, MD, 20892.; Source Info: Jan99 Supplement, Vol. 72, pS65; Subject Term: LINOLENIC acids; Subject Term: ESSENTIAL fatty acids; Subject Term: PHOSPHOLIPIDS; Subject Term: DOCOSAHEXAENOIC acid; Subject Term: CONFERENCES & conventions; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: ABSTRACTS; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 1/4p; Document Type: Abstract
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23343648&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Yarger, D. E.
AU  - Rapaport, S. I.
AU  - Murphy, E. J.
T1  - A CONTINUOUS FLUOROMETRIC ASSAY FOR PHOSPHOLIPASE A2 ACTIVITY IN BRAIN CYTOSOL.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S66
EP  - S66
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the paper "A Continuous Fluorometric Assay for Phospholipase A2 Activity in Brain Cytosol," which will be presented at the 30th Annual Meeting of the American Society for Neurochemistry to be held from March 14-17, 1999 in New Orleans, Louisiana. The samples were extracted by single phase extraction, chromatographically verified presence of pyrene labeled free fatty acids and the absence of pyrene labeled lysophospholipids and diaglycerides.
KW  - PHOSPHOLIPASE A2
KW  - PHOSPHOLIPASES
KW  - FATTY acids
KW  - PHOSPHOLIPIDS
KW  - CONFERENCES & conventions
KW  - ASSOCIATIONS, institutions, etc.
KW  - ABSTRACTS
N1  - Accession Number: 23343649; Yarger, D. E. 1,2 Rapaport, S. I. 1 Murphy, E. J. 1; Affiliation:  1: Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.  2: Department of Biology, Cumberland College, Williamsburg, KY 40769.; Source Info: Jan99 Supplement, Vol. 72, pS66; Subject Term: PHOSPHOLIPASE A2; Subject Term: PHOSPHOLIPASES; Subject Term: FATTY acids; Subject Term: PHOSPHOLIPIDS; Subject Term: CONFERENCES & conventions; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: ABSTRACTS; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 1/4p; Document Type: Abstract
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23343649&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Yarger, D. E.
AU  - Ramassamy, C.
AU  - Krzywkowski, P.
AU  - Poirier, J.
AU  - Rapoport, S. I.
AU  - Murphy, E. J.
T1  - REGIONAL PHOSPHOLIPASE A2 ACTIVITY IN APOLIPOPROTEIN E GENOTYPED ALZHEIMER DISEASE BRAINS.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S74
EP  - S74
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the research "Regional Phospholipase A2 (PLA2) Activity in Apolipoprotein E (Apo-E) Genotyped Alzheimer Disease (AD) Brains," which will be presented at the American Society for Neurochemistry's 30th Annual Meeting to be held in New Orleans, Louisiana on March 14-17, 1999. In this study, a continuous flurometric assay was used to analyze PLA2 activity in AD brain tissue and control patients genotyped for the Apo-E 2,3 and 4 alleles.
KW  - NEUROCHEMISTRY
KW  - APOLIPOPROTEIN E
KW  - ALZHEIMER'S disease
KW  - PHOSPHOLIPASE A2
KW  - BIOCHEMISTRY
KW  - MEDICAL research
KW  - ABSTRACTS
N1  - Accession Number: 23343681; Yarger, D. E. 1,2 Ramassamy, C. 3 Krzywkowski, P. 3 Poirier, J. Rapoport, S. I. 2 Murphy, E. J. 2; Affiliation:  1: Department of Biology, Cumberland College, Williamsburg, KY 40769.  2: Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.  3: Douglas Hospital Research Center, Verdun, Quebec.; Source Info: Jan99 Supplement, Vol. 72, pS74; Subject Term: NEUROCHEMISTRY; Subject Term: APOLIPOPROTEIN E; Subject Term: ALZHEIMER'S disease; Subject Term: PHOSPHOLIPASE A2; Subject Term: BIOCHEMISTRY; Subject Term: MEDICAL research; Subject Term: ABSTRACTS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1/4p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Guroff, Gordon
T1  - THE ROLE OF CALCIUM UPTAKE IN NEUROTROPHIN-INDUCED SURVIVAL, PROTECTION, AND SYNAPTIC PLASTICITY.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/01/02/Jan99 Supplement
VL  - 72
M3  - Abstract
SP  - S89
EP  - S89
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the study titled "The Role of Calcium Uptake in Neurotrophin-induced Survival, Protection and Synaptic Plasticity." The study delves into the neurotrophin-mediated calcium-uptake. The paper will be presented during the 30th Annual Meeting of the American Society for Neurochemistry, in New Orleans, Louisiana, from March 14-17, 1999.
KW  - CALCIUM
KW  - NEUTROPENIA
KW  - NEUROTROPHINS
KW  - NEUROPHYSIOLOGY
KW  - NEUROPLASTICITY
KW  - NEURONS
KW  - ABSTRACTS
N1  - Accession Number: 23343744; Guroff, Gordon 1; Affiliation:  1: Section on Growth Factors, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.; Source Info: Jan99 Supplement, Vol. 72, pS89; Subject Term: CALCIUM; Subject Term: NEUTROPENIA; Subject Term: NEUROTROPHINS; Subject Term: NEUROPHYSIOLOGY; Subject Term: NEUROPLASTICITY; Subject Term: NEURONS; Subject Term: ABSTRACTS; Number of Pages: 1/4p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 106882878
T1  - Matrix metalloproteinases-9 in preterm and term human parturition.
AU  - Athayde N
AU  - Romero R
AU  - Gomez R
AU  - Maymon E
AU  - Pacora P
AU  - Mazor M
AU  - Yoon BH
AU  - Fortunato S
AU  - Menon R
AU  - Ghezzi F
AU  - Edwin SS
Y1  - 1999/01/05/
N1  - Accession Number: 106882878. Language: English. Entry Date: 20031107. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9211288. 
KW  - Amniotic Fluid -- Analysis
KW  - Labor, Premature
KW  - Metalloproteins -- Pharmacodynamics
KW  - Cross Sectional Studies
KW  - Female
KW  - Fetal Membranes, Premature Rupture -- Physiopathology
KW  - Fetal Membranes, Premature Rupture -- Risk Factors
KW  - Gestational Age
KW  - Immunoassay
KW  - Korea
KW  - Pregnancy
KW  - Spearman's Rank Correlation Coefficient
KW  - Wilcoxon Rank Sum Test
KW  - Zinc
KW  - Human
SP  - 213
EP  - 219
JO  - Journal of Maternal-Fetal Medicine
JF  - Journal of Maternal-Fetal Medicine
JA  - J MATERN FETAL MED
VL  - 8
IS  - 5
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - OBJECTIVE: Spontaneous rupture of the fetal membranes occurs after the commencement of labor in 90% of cases. Recent evidence indicates that the process of parturition requires not only an increase in myometrial contractility and cervical ripening, but also degradation of extracellular matrix in fetal membranes (i.e., leakage of fibronectin into cervico-vaginal secretions). This study was undertaken to determine if parturition is associated with in vivo evidence of increased bioavailability of matrix metalloproteinases-9 (MMP-9) and its inhibitor, tissue inhibitor of metalloproteinases-1(TIMP-1). METHODS: A cross-sectional study was conducted with women in the following categories: 1) midtrimester (n = 25); 2) preterm labor and intact membranes in the absence of intraamniotic infection (n = 78); 3) term not in labor (n = 25); and 4) term with intact membranes in labor (n = 25). MMP-9, and TIMP-1 were measured using sensitive and specific immunoassays. RESULTS: 1) Spontaneous labor at term was associated with a significant increase in MMP-9 but not in TIMP-1.2) Women with preterm labor who delivered prematurely had significantly higher concentrations of MMP-9 but not TIMP-1 in amniotic fluid than those with preterm labor who delivered at term. 3) The concentrations of TIMP-1 decreased with advancing gestational age. In contrast, MMP-9 concentrations did not change with advancing gestational age. CONCLUSIONS: Spontaneous human parturition is associated with specific changes in the enzymatic machinery responsible for extracellular matrix degradation.
SN  - 1057-0802
AD  - Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland
U2  - PMID: 10475503.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106882878&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091109
T1  - Foreword.
AU  - Klausner RD
Y1  - 1999/01/06/
N1  - Accession Number: 107091109. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Neoplasms
KW  - Risk Factors
KW  - Communication
SP  - 1
EP  - 1
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Director, National Cancer Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091109&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091110
T1  - The cancer risk communication meeting in perspective.
AU  - Rimer BK
Y1  - 1999/01/06/
N1  - Accession Number: 107091110. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Communication
KW  - Risk Factors
KW  - Neoplasms
SP  - 3
EP  - 3
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091110&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091108
T1  - Introduction of section: challenges inherent in communicating cancer risk information.
AU  - Van Nevel JP
Y1  - 1999/01/06/
N1  - Accession Number: 107091108. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Risk Factors
KW  - Neoplasms
KW  - Communication
SP  - 5
EP  - 5
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Office of Cancer Communications, National Cancer Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091108&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091116
T1  - Introduction of section: enabling informed decisions about cancer risk.
AU  - Biesecker BB
Y1  - 1999/01/06/
N1  - Accession Number: 107091116. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Decision Making, Patient
KW  - Neoplasms
KW  - Communication
SP  - 43
EP  - 43
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091116&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091121
T1  - Risk communication in genetic testing for cancer susceptibility.
AU  - Croyle RT
AU  - Lerman C
Y1  - 1999/01/06/
N1  - Accession Number: 107091121. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Neoplasms -- Psychosocial Factors
KW  - Genetic Counseling
KW  - Communication
KW  - Decision Making
SP  - 59
EP  - 66
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091121&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091136
T1  - Introduction of section: implications for improving risk communication through various channels.
AU  - Van Nevel JP
Y1  - 1999/01/06/
N1  - Accession Number: 107091136. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Communication -- Methods
KW  - Risk Factors
KW  - Neoplasms
SP  - 123
EP  - 124
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Office of Cancer Communications, National Cancer Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091136&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091146
T1  - Is there a use for tailored print communications in cancer risk communication?...including commentary by Russell C
AU  - Rimer BK
AU  - Glassman B
Y1  - 1999/01/06/
N1  - Accession Number: 107091146. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Public Health Service grants 1P01CA72099 and 1P50CA68438-02 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. NLM UID: 7503089. 
KW  - Communication
KW  - Neoplasms
KW  - Consumer Health Information
KW  - Risk Factors
KW  - Print Materials
KW  - Neoplasms -- Prevention and Control
KW  - Risk Assessment
KW  - Funding Source
SP  - 140
EP  - 178
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091146&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107091167
T1  - Introduction of section: breakout session reports.
AU  - Van Nevel JP
Y1  - 1999/01/06/
N1  - Accession Number: 107091167. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Risk Factors
KW  - Communication
KW  - Neoplasms
SP  - 179
EP  - 185
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 1
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, Bldg. 31, Rm. 10A31, MSC 2580, Bethesda, MD 20892. E-mail: nevelp@occ.nci.nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091167&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Matsui, Minoru
AU  - Breau, Walter C.
AU  - Iwasaki, Shi ho
AU  - Hagiwara, Sadahiro
AU  - Tamai, Yoshitaka
AU  - Mori, Chisato
AU  - Bloom, Michael L.
AU  - Jerry, Mary B.
AU  - Eddy, Edward M.
AU  - Taketo, Makoto M.
T1  - Retrovirus Integration Site Mintb Encoding the Mouse Homolog of hnRNP U1.
JO  - Journal of Biochemistry
JF  - Journal of Biochemistry
Y1  - 1999/01/06/
VL  - 125
IS  - 6
M3  - Article
SP  - 1104
EP  - 1114
SN  - 0021924X
N1  - Accession Number: 80085925; Matsui, Minoru 1 Breau, Walter C. 2 Iwasaki, Shi ho 1 Hagiwara, Sadahiro 1 Tamai, Yoshitaka 3 Mori, Chisato 4 Bloom, Michael L. 2 Jerry, Mary B. 2 Eddy, Edward M. 4 Taketo, Makoto M. 1,2,3; Affiliation:  1: Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo Tokyo 113-0033  2: The Jackson Laboratory Bar Harbor, ME 04609, USA  3: Banyu Tsukuba Research Institute (Merck) Tsukuba 300-2611  4: Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, NC 27709, USA; Source Info: 1999, Vol. 125 Issue 6, p1104; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107173498
T1  - Problems in the management of attention-deficit-hyperactivity disorder.
AU  - Zametkin AJ
AU  - Ernst M
Y1  - 1999/01/07/
N1  - Accession Number: 107173498. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Attention Deficit Hyperactivity Disorder -- Diagnosis
KW  - Attention Deficit Hyperactivity Disorder -- Therapy
KW  - Diagnosis, Differential
KW  - Child
KW  - Male
KW  - Female
KW  - Adult
KW  - Attention Deficit Hyperactivity Disorder -- Drug Therapy
KW  - Behavior Therapy
KW  - Central Nervous System Stimulants -- Therapeutic Use
SP  - 40
EP  - 46
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 340
IS  - 1
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Institute of Mental Health, 10 Center Dr., Bethesda, MD 20892
U2  - PMID: 9878644.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107173498&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Natarajan, V.;
AU  - Bosche, M.;
AU  - Metcalf, J. A.;
AU  - Ward, D. J.;
AU  - Kovacs, J. A.;
AU  - \ET/;
T1  - HIV-1 replication in patients with undetectable plasma virus receiving HAART
CT  - HIV-1 replication in patients with undetectable plasma virus receiving HAART
JO  - Lancet (England)
JF  - Lancet (England)
Y1  - 1999/01/09/
VL  - 353
IS  - Jan 9
SP  - 119
EP  - 120
SN  - 00237507
AD  - Critical Care Med. Dept., Clin. Ctr., NIH, Bethesda, MD 20892, USA Internet: jkovacs@nih.gov
N1  - Accession Number: 36-07563; Language: English; References: 5; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ellen Katz Neumann
N2  - Human immunodeficiency virus (HIV)-1 replication was studied in 26 male patient with HIV infection and undetectable plasma virus who had been receiving highly active antiretroviral therapy for a mean duration of 19 months. Peripheral blood mononuclear cells (PBMCs) were examined for evidence of ongoing viral replication. In all but 2 patients, cell-associated HIV-1 RNA could be detected with gag-specific primers. In all cases, a control with no reverse transcriptase control was negative. In the remaining 2 patients, HIV-1 RNA was detected in lymph node or rectal biopsies. With a seminested PCR technique, multiply spliced RNA was detected in PBMCs from 14 of 26 patients and in 1 or 2 tissue samples. Proviral DNA was detected in the PBMCs of all patients.
KW  - Antiretroviral agents--HIV infections--HIV-1 replication;
KW  - HIV infections--antiretroviral agents--HIV-1 replication;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107186188
T1  - Resolved -- resources for critical care nurses.
AU  - Byram D
Y1  - 1999/01/11/1999 Jan 11
N1  - Accession Number: 107186188. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Nursing; USA. NLM UID: 9421079. 
KW  - Critical Care Nursing
KW  - Information Resources
SP  - 15
EP  - 15
JO  - Nursing Spectrum -- Washington DC & Baltimore Edition
JF  - Nursing Spectrum -- Washington DC & Baltimore Edition
JA  - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL  - 9
IS  - 1
CY  - Falls Church, VA 22042, Illinois
PB  - Gannett Healthcare Group
SN  - 1098-9153
AD  - Nurse Consultant, Critical/Acute Care Patient Services, National Institutes of Health, Bethesda, MD
U2  - PMID: 10542796.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107186188&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107205149
T1  - Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams.
AU  - Culnane M
AU  - Fowler M
AU  - Lee SS
AU  - McSherry G
AU  - Brady M
AU  - O'Donnell K
AU  - Mofenson L
AU  - Gortmaker SL
AU  - Shapiro DE
AU  - Scott G
AU  - Jimenez E
AU  - Moore EC
AU  - Diaz C
AU  - Flynn PM
AU  - Cunningham B
AU  - Oleske J
AU  - Culnane, M
AU  - Fowler, M
AU  - Lee, S S
AU  - McSherry, G
Y1  - 1999/01/13/
N1  - Accession Number: 107205149. Language: English. Entry Date: 19990801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Zuccotti G V, Agostoni C, D'Auria E, Torcoletti M, Riva E. Infant growth after in utero exposure to zidovudine. (JAMA) 8/11/99; 282 (6): 527-529. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Bayley Scales of Infant Development; McCarthy Scales of Children's Abilities. NLM UID: 7501160. 
KW  - Disease Transmission, Vertical -- Prevention and Control
KW  - HIV Infections -- Prevention and Control -- In Infancy and Childhood
KW  - Pregnancy Complications, Infectious -- Prevention and Control
KW  - Zidovudine -- Therapeutic Use -- In Pregnancy
KW  - Prenatal Exposure Delayed Effects
KW  - Prospective Studies
KW  - Chi Square Test
KW  - Fisher's Exact Test
KW  - Confidence Intervals
KW  - P-Value
KW  - Research Instruments
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Pregnancy
KW  - Male
KW  - Female
KW  - Human
SP  - 151
EP  - 157
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 281
IS  - 2
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: With the success of zidovudine chemoprophylaxis for prevention of perinatal transmission of the human immunodeficiency virus (HIV), an increasing number of HIV-exposed but uninfected children will have in utero exposure to zidovudine and other antiretroviral drugs.Objective: To evaluate the long-term effects of in utero exposure to zidovudine vs placebo among a randomized cohort of uninfected children.Design: Prospective cohort study based on data collected during Pediatric AIDS Clinical Trials Group Protocol 076, a perinatal zidovudine HIV prevention trial, and Protocol 219, a long-term observational protocol.Setting: Pediatric research clinics in the United States.Patients: Two hundred thirty-four uninfected children born to 230 HIV-infected women enrolled in Protocol 076 and followed up through February 28, 1997, in Protocol 219 (122 in the zidovudine group and 112 in the placebo group).Main Outcome Measures: Physical growth measurements, immunologic parameters, cognitive/developmental function, occurrence of neoplasms, and mortality data assessed every 6 months for children younger than 24 months and yearly thereafter or as clinically indicated. Baseline echocardiogram and funduscopic evaluations were collected before 36 months of age.Results: Median age of children at time of last follow-up visit was 4.2 years (range, 3.2-5.6 years). There were no significant differences between children exposed to zidovudine and those who received placebo in terms of sequential data on lymphocyte subsets; weight, height, and head circumference z scores; and cognitive/developmental function. No deaths or malignancies occurred. Two children (both exposed to zidovudine) are being followed up for abnormal, unexplained ophthalmic findings. One child exposed to zidovudine had a mild cardiomyopathy on echocardiogram at the age of 48 months; the child is clinically asymptomatic.Conclusions: No adverse effects were observed in HIV-uninfected children with in utero and neonatal exposure to zidovudine followed up for as long as 5.6 years. Continued prospective evaluations of children born to HIV-infected women who are exposed to antiretroviral or immunotherapeutic agents are critical to assess the long-term safety of interventions that prevent perinatal HIV transmission.
SN  - 0098-7484
AD  - Pediatric Medicine Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7620, USA
U2  - PMID: 9917118.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107205149&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Culnane, M.;
AU  - Fowler, M. G.;
AU  - Lee, S. S.;
AU  - McSherry, G.;
AU  - Oleske, J.;
AU  - \ET/;
T1  - Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women
CT  - Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women
JO  - Journal of the American Medical Association (USA)
JF  - Journal of the American Medical Association (USA)
Y1  - 1999/01/13/
VL  - 281
IS  - Jan 13
SP  - 151
EP  - 157
SN  - 00987484
AD  - Pediatr. Med. Branch, Div. of AIDS, Natl. Inst. of Allergy and Infect. Dis., NIH, 9000 Rockville Pike, Bethesda, MD 20892-7620, USA Internet: mc38f@nih.gov
N1  - Accession Number: 36-04447; Language: English; Chemical Name: Zidovudine--30516-87-1; References: 21; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Peggy L. Ruppel
N2  - A study evaluating the long term effects of in utero zidovudine exposure on the uninfected children of women who were human immunodeficiency virus (HIV) positive during pregnancy was conducted among 234 uninfected children, ages 3.2-5.6 yr at last follow-up, born to 230 HIV-infected women, 122 of whom had received zidovudine to prevent perinatal transmission and 112 had received a placebo. There were no significant differences between children exposed to zidovudine and those who received placebo in terms of sequential data on lymphocyte subsets; weight, height, and head circumference z scores; and cognitive/developmental function. No deaths or malignancies occurred.
KW  - Zidovudine--teratogenicity-;
KW  - Antiretroviral agents--zidovudine--teratogenicity;
KW  - Teratogenicity--zidovudine--pediatrics;
KW  - Pregnancy--zidovudine--teratogenicity;
KW  - Toxicity--zidovudine--teratogenicity;
KW  - Abnormalities--zidovudine--teratogenicity;
KW  - Placental transfer--zidovudine--teratogenicity;
KW  - Pediatrics--zidovudine--teratogenicity;
KW  - HIV infections--zidovudine--teratogenicity;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Lewis, Dale E. A
AU  - Geanacopoulos, Mark
AU  - Adhya, Sankar
T1  - Role of HU and DNA supercoiling in transcription repression: specialized nucleoprotein repression complex at gal promoters in Escherichia coli.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1999/01/15/
VL  - 31
IS  - 2
M3  - Article
SP  - 451
EP  - 461
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Efficient repression of the two promoters P 1 and P 2 of the gal operon requires the formation of a DNA loop encompassing the promoters. In vitro , DNA looping-mediated repression involves binding of the Gal repressor (GalR) to two gal operators (O E and O I ) and binding of the histone-like protein HU to a specific locus (hbs ) about the midpoint between O E and O I , and supercoiled DNA. Without DNA looping, GalR binding to O E partially represses P 1 and stimulates P 2. We investigated the requirement for DNA supercoiling and HU in repression of the gal promoters in vivo in strains containing a fusion of a reporter gene, gusA or lacZ , to each promoter individually. While the P 1 promoter was found to be repressible in the absence of DNA supercoiling and HU, the repression of P 2 was entirely dependent upon DNA supercoiling in vivo . The P 2 promoter was fully derepressed when supercoiling was inhibited by the addition of coumermycin in cells. P 2, but not P 1, was also totally derepressed by the absence of HU or the O I operator. From these results, we propose that the repression of the gal promoters in vivo is mediated by the formation of a higher order DNA–multiprotein complex containing GalR, HU and supercoiled DNA. In the absence of this complex, P 1 but not P 2 is still repressed by GalR binding to O E . The specific nucleoprotein complexes involving histone-like proteins, which repress promoter activity while remaining sensitive to inducing signals, as discussed, may occur more generally in bacterial nucleoids. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - Genetic repressors
N1  - Accession Number: 6008301; Lewis, Dale E. A 1; Geanacopoulos, Mark 1; Adhya, Sankar 1; Affiliations: 1: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.; Issue Info: Jan1999, Vol. 31 Issue 2, p451; Subject Term: DNA; Subject Term: Genetic repressors; Number of Pages: 11p; Illustrations: 6 Diagrams, 1 Chart, 22 Graphs; Document Type: Article
L3  - 10.1046/j.1365-2958.1999.01186.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=6008301&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Emanuel, Ezekiel J.
T1  - EIGHT IS TOO MANY.
JO  - New Republic
JF  - New Republic
Y1  - 1999/01/25/
VL  - 220
IS  - 4
M3  - Article
SP  - 8
EP  - 11
PB  - TNR II, LLC
SN  - 00286583
AB  - Opposes the use of the reproductive technology which produces large multiple births. Examples of Bobbi McCaughey septuplets in Iowa and Nkem Chukwu octuplets in Texas; Medical problems evident in multiple births; High level of infant mortality and long-term health complications; Emotional health risks of children in multiple births; Demands on parents of such children; Volunteers who help the McCaugheys; Rarity of parental time for each child.
KW  - CHILDBIRTH
KW  - MEDICAL errors
KW  - MULTIPLE birth
KW  - MULTIPLE pregnancy
KW  - REPRODUCTIVE technology
KW  - CHILDREN -- Health
KW  - MCCAUGHEY, Bobbi
KW  - NKEM Chukwu
N1  - Accession Number: 1468134; Emanuel, Ezekiel J. 1; Affiliation:  1: Chairman of the Department of Clinical Bioethics, National Institutes of Health.; Source Info: 01/25/99, Vol. 220 Issue 4, p8; Subject Term: CHILDBIRTH; Subject Term: MEDICAL errors; Subject Term: MULTIPLE birth; Subject Term: MULTIPLE pregnancy; Subject Term: REPRODUCTIVE technology; Subject Term: CHILDREN -- Health; People: MCCAUGHEY, Bobbi; People: NKEM Chukwu; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1802
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107232015
T1  - The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping.
AU  - Ellsworth DL
AU  - Manolio TA
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 107232015. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; glossary; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Epidemiological Research -- Trends
KW  - Genetic Techniques -- Trends
KW  - Genetics, Medical
KW  - Study Design
KW  - Genetic Markers
KW  - Hereditary Diseases
KW  - Genes
KW  - Research Subjects
SP  - 75
EP  - 90
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 9
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: To provide a synthesis of current approaches to the discovery of genes associated with complex human diseases by examining the joint potential of traditional epidemiologic methods and current molecular techniques for gene discovery. METHODS: A discussion of optimal approaches for defining complex disease phenotypes in genetic epidemiology, ascertainment strategies for estimating genetic influences on disease risk, genomic approaches for localizing complex-disease-susceptibility genes, and the potential synergistic effects of integrating genetic and traditional epidemiologic expertise is provided in the second part of a three-part series on the importance of genetics in epidemiologic research. RESULTS: The ability to quantify genetic influences on disease risk appears highly dependent on the measurement of specific risk factor traits, ascertainment strategies for recruiting study subjects, and a variety of genomic approaches that are rapidly facilitating our ability to identify genes influencing inherited human diseases and to quantify genetic influences on disease risk. CONCLUSIONS: Integrating population-based methods of assessing disease risk with human genetics and genome technology is critical for identifying genetic polymorphisms that influence risk of disease and for defining genetic effects on complex disease etiology.
SN  - 1047-2797
AD  - Epidemiology and Biometry Program, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Dr. MSC 7 934, Bethesda, Maryland 20892-7934
U2  - PMID: 10037550.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107232015&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107232020
T1  - Age-adjusted death rates: consequences of the year 2000 standard [corrected] [published erratum appears in ANN EPIDEMIOL 1999 Jul; 9(5): 332-3].
AU  - Sorlie PD
AU  - Thom TJ
AU  - Manolio T
AU  - Rosenberg HM
AU  - Anderson TN
AU  - Burke GL
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 107232020. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; standards; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Mortality -- Trends
KW  - Age Factors -- Standards
KW  - Data Analysis, Statistical -- Methods
KW  - Bias (Research)
KW  - Epidemiology
KW  - Methodological Research
KW  - Epidemiological Research
KW  - Analysis of Variance
KW  - Confidence Intervals
KW  - Myocardial Ischemia -- Mortality
KW  - Neoplasms -- Mortality
KW  - HIV Infections -- Mortality
KW  - Cardiovascular Diseases -- Mortality
KW  - Vital Statistics
KW  - Reference Values
KW  - United States
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Human
SP  - 93
EP  - 100
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 9
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: For nearly 60 years, official U.S. mortality statistics have been age-adjusted using the age distribution from the U.S. population for the year 1940. A new population standard, the projected Year 2000 U.S. standard, has been approved for use by the Department of Health and Human Services (DHHS). It will be implemented for official U.S. Government statistics published for deaths occurring in 1999. The new standard reflects the older age distribution of the population; 6.8% of the population was age 65 years or more in 1940, as compared to 12.6% projected for 2000. METHODS: This paper investigates the consequences of the new age distribution standard by comparing death rates by time, place, and population characteristics, adjusted to both the 1940 and projected 2000 population standards. RESULTS: The new standard changes the level of the age-adjusted death rate for total mortality and for many causes of death, as compared to the 1940 standard. For example, the 1995 death rate for diseases of the heart is 138 per 100,000 population when adjusted using the 1940 standard, but is 296 per 100,000 using the Year 2000 standard. The new standard may change the comparison of age-adjusted rates if there are substantial differences in the age-specific rates. For example, the ratio of age-adjusted death rates for ischemic heart disease in black relative to white males is 1.07 using the 1940 standard, but is 0.96 using the Year 2000 standard. CONCLUSIONS: The new Year 2000 age standard has the potential to change both levels and comparisons of age-adjusted rates. Age-adjustment is an averaging process, and consequently, has the potential to view the data effectively as a whole while possibly obscuring important age-specific details.
SN  - 1047-2797
AD  - Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, NIH, II Rockledge Center, MSC 7934, 6701 Rockledge Drive, Bethesda, MD 20892
U2  - PMID: 10037552.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107232020&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107200888
T1  - Disability, physical activity, and muscle strength in older women: the Women's Health and Aging Study.
AU  - Rantanen T
AU  - Guralnik JM
AU  - Sakari-Rantala R
AU  - Leveille S
AU  - Simonsick EM
AU  - Ling S
AU  - Fried LP
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 107200888. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985158R. 
KW  - Disabled -- In Old Age
KW  - Women -- In Old Age
KW  - Functional Status
KW  - Physical Activity
KW  - Muscle Strength
KW  - Cross Sectional Studies
KW  - Female
KW  - Women's Health
KW  - Aged
KW  - Aged, 80 and Over
KW  - Dynamometry
KW  - Disability Evaluation
KW  - Community Living
KW  - Multiple Regression
KW  - Pearson's Correlation Coefficient
KW  - Spearman's Rank Correlation Coefficient
KW  - Chi Square Test
KW  - Grip Strength
KW  - Models, Theoretical
KW  - Human
SP  - 130
EP  - 135
JO  - Archives of Physical Medicine & Rehabilitation
JF  - Archives of Physical Medicine & Rehabilitation
JA  - ARCH PHYS MED REHABIL
VL  - 80
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVE: To study associations of motor disability, physical activity, and muscle strength in older women, in particular to investigate whether model of spiraling decrease is expressed in the data. DESIGN: Cross-sectional analysis using data from the baseline measurements of The Women's Health and Aging Study (WHAS). SETTING: Participants' homes. PARTICIPANTS: A total of 1,002 disabled women aged 65 years and older living in the community. OUTCOME MEASURES: Motor disability was measured by the number of self-reported difficulties in grasping, lifting 101b, walking across a small room, walking 1/4 mile, climbing 10 steps, and doing heavy housework. Level of physical activity was determined from response to a series of questions on the frequency and amount of common activities and physical exercise. Hand grip and knee extension forces were measured using portable hand-held dynamometers. RESULTS: Disability and physical activity were inversely associated, with inactivity being most common among the most disabled women. Those with poorer strength reported more difficulties in motor activities. Greater strength was found among the physically more active. In stratified analyses, the positive association of physical activity on knee extension strength was consistent across disability levels. Multiple regression analysis showed that both physical activity and muscle strength were significant predictors for severity of disability. Structural equation model (LISREL) showed that muscle strength had a mediating role between physical activity and disability; disability was associated with physical inactivity, which correlated with lower muscle strength, which was associated with greater degree of disability. CONCLUSION: Even though causality cannot be confirmed in this cross-sectional analysis, our findings suggested a spiraling model of decline in which muscle strength has a significant role. Copyright (c) 1999 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation
SN  - 0003-9993
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave, Gateway Bldg, Ste 3C-309, Bethesda, MD 20892
U2  - PMID: 10025485.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Alexander, D.;
T1  - Pediatric Pharmacology Research Unit Network of the National Institute of Child Health and Human Development
CT  - Pediatric Pharmacology Research Unit Network of the National Institute of Child Health and Human Development
JO  - Drug Information Journal (USA)
JF  - Drug Information Journal (USA)
Y1  - 1999/02/01/
VL  - 33
IS  - Feb
SP  - 385
EP  - 391
SN  - 00928615
AD  - National Institute of Child Health and Human Development, 31 Center Dr., Bldg. 31, Rm. 2A03, MSC 2425, Bethesda, MD 20892-2524, USA Internet: AlexanderD@exchange.nih.gov
N1  - Accession Number: 37-06258; Language: English; References: 1; Journal Coden: DGIJB9; Section Heading: Legislation, Laws and Regulations; Abstract Author: Lisa Webster
N2  - A description of the National Institutes of Health's (NIH) Pediatric Pharmacology Research Unit Network, established to address the lack of testing in children of drugs used to treat children, is presented. The Network was developed in 1994 to address the concern that there was no satisfactory place to test children, to provide top quality data that would facilitate pediatric labeling, and to demonstrate that this could be done. The Network's developments, accomplishments, and plans for the 21st century are covered.
KW  - Clinical studies--pediatrics--pediatric drug research;
KW  - Research--pediatrics--clinical studies;
KW  - Pediatrics--clinical studies--Pediatric Pharmacology Research Unit Network;
KW  - National Institutes of Health--pediatrics--clinical studies;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Jakob, Thilo
AU  - Walker, Patricia S.
AU  - Krieg, Arthur M.
AU  - von Stebut, Esther
AU  - Udey, Mark C.
AU  - Vogel, Jonathan C.
T1  - Bacterial DNA and CpG–Containing Oligodeoxynucleotides Activate Cutaneous Dendritic Cells and Induce IL–12 Production: Implications for the Augmentation of Th1 Responses.
JO  - International Archives of Allergy & Immunology
JF  - International Archives of Allergy & Immunology
Y1  - 1999/02//
VL  - 118
IS  - 2-4
M3  - Article
SP  - 457
EP  - 461
SN  - 10182438
AB  - Background: Unmethylated CpG sequences in bacterial DNA act as adjuvants selectively inducing Th1 predominant immune responses during genetic vaccination or when used in conjunction with protein Ag. The precise mechanism of this adjuvant effect is unknown. Because dendritic cells (DC) are thought to be crucially involved in T cell priming and Th1/Th2 education during vaccination via skin, we characterized the effects of bacterial DNA and CpG–containing oligodeoxynucleotides (CpG ODN) on cutaneous DC. Methods and Results: Stimulation with CpG ODN 1826 (6 μg/ml) induced activation of immature Langerhans cell (LC)–like DC as determined by an increased expression of MHC class II and costimulatory molecules, loss of E–cadherin–mediated adhesion and increased ability to stimulate allogeneic T cells. Composition–matched control ODN 1911 lacking CpG sequences at equal concentrations was without effect. In comparison to LPS and ODN 1911, CpG ODN 1826 selectively stimulated DC to release large amounts of IL–12 (p40) and little IL–6 or TNF–α within 18 h and detectable levels of IL–12 p70 within 72 h. Stimulation with Escherichia coli DNA, but not calf thymus DNA, similarly induced DC maturation and IL–12 p40 production. Injection of CpG ODN into murine dermis induced enhanced expression of MHC class II and CD86 by LC in the overlying epidermis and intracytoplasmic IL–12 p40 accumulation in a subpopulation of activated LC. Conclusion: Bacterial DNA and CpG ODN stimulate DC in vitro and in vivo and may preferentially elicit Th1–predominant immune responses because they can activate and mobilize DC, inducing them to produce IL–12. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Archives of Allergy & Immunology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DENDRITIC cells
KW  - DNA
KW  - LANGERHANS cells
KW  - INTERLEUKIN-12
KW  - INTERLEUKINS
KW  - DANN
KW  - IL–12
KW  - Langerhans cells
KW  - Oligodeoxynucleotides
N1  - Accession Number: 11335370; Jakob, Thilo 1 Walker, Patricia S. 1 Krieg, Arthur M. 2 von Stebut, Esther 1 Udey, Mark C. 1 Vogel, Jonathan C. 1; Affiliation:  1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.  2: Veterans Affairs Medical Center and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA; Source Info: 1999, Vol. 118 Issue 2-4, p457; Subject Term: DENDRITIC cells; Subject Term: DNA; Subject Term: LANGERHANS cells; Subject Term: INTERLEUKIN-12; Subject Term: INTERLEUKINS; Author-Supplied Keyword: DANN; Author-Supplied Keyword: IL–12; Author-Supplied Keyword: Langerhans cells; Author-Supplied Keyword: Oligodeoxynucleotides; Number of Pages: 5p; Document Type: Article
L3  - 10.1159/000024163
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Haynie, Michael Katherine
AU  - Lundquist, Andrew L.
AU  - Suomi, Stephen J.
T1  - Carrying, Sharing, and Hand Preference in Tufted Capuchins (Cebus apella).
JO  - International Journal of Primatology
JF  - International Journal of Primatology
Y1  - 1999/02//
VL  - 20
IS  - 1
M3  - Article
SP  - 153
EP  - 162
PB  - Springer Science & Business Media B.V.
SN  - 01640291
AB  - We examined the relationship among carrying, food-sharing, and hand preference in tufted capuchins (Cebus apella). The rationale was to evaluate further the use of Cebus as an alternative primate model to Pan for behavior relevant to early hominid evolution. We first examined bipedalism and food-sharing within an established social group, and then examined the direction and strength of hand preference for food carrying in an expanded sample. Several aspects of capuchin behavior warrant discussion. First, bipedal carrying and food-sharing occurred more frequently when we provided bulky foods than when we provided smaller foods. Second, food-sharing was characterized by passive tolerance, rather than active giving, between subjects. Third, subjects shared food primarily with immatures and followed a pattern of reciprocal exchange. Finally, we found no evidence for population-level hand preference for carrying. We posit that an array of behavioral similarities among Cebus, Pan, and Homo evolved through convergent processes, and in this regard capuchins can be seen as an alternative primate model to chimpanzees for the evolution of early hominid behavior. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Primatology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BEHAVIOR
KW  - Capuchin monkeys
KW  - Bipedalism
KW  - capuchin
KW  - carrying
KW  - food sharing
KW  - hand preference
N1  - Accession Number: 1972177; Westergaard, Gregory Charles 1; Haynie, Michael Katherine 2; Lundquist, Andrew L. 2; Suomi, Stephen J. 2; Affiliations: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development. National Institutes of Health Animal Center, Poolesville, Maryland 20837; 2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development; Issue Info: Feb99, Vol. 20 Issue 1, p153; Thesaurus Term: BEHAVIOR; Subject Term: Capuchin monkeys; Subject Term: Bipedalism; Author-Supplied Keyword: capuchin; Author-Supplied Keyword: carrying; Author-Supplied Keyword: food sharing; Author-Supplied Keyword: hand preference; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 104717255
T1  - Towards a philosophy of public health.
AU  - Weed, D L
Y1  - 1999/02//
N1  - Accession Number: 104717255. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 7909766. 
KW  - Philosophy
KW  - Public Health
KW  - Decision Making
KW  - Ethics
KW  - Knowledge
KW  - Preventive Health Care
KW  - Risk Assessment
SP  - 99
EP  - 104
JO  - Journal of Epidemiology & Community Health
JF  - Journal of Epidemiology & Community Health
JA  - J EPIDEMIOL COMMUNITY HEALTH
PB  - BMJ Publishing Group
SN  - 0143-005X
AD  - Preventive Oncology Branch, National Cancer Institute, Bethesda, MD 20892-7105, USA.
U2  - PMID: 10396470.
DO  - 10.1136/jech.53.2.99
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107201861
T1  - Impact of childhood out-of-home placement on a Southwestern American Indian tribe.
AU  - Robin RW
AU  - Rasmussen JK
AU  - Gonzalez-Santin E
Y1  - 1999/02//
N1  - Accession Number: 107201861. Language: English. Entry Date: 19990801. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Schedule for Affective Disorders and Schizophrenia-Lifetime version (SADS-L) (Spitzer et al); Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised (DSM-III-R). NLM UID: 9890976. 
KW  - Foster Home Care
KW  - Native Americans
KW  - Mental Disorders -- Ethnology
KW  - Southwestern United States
KW  - Focus Groups
KW  - Interviews
KW  - DSM
KW  - Kappa Statistic
KW  - Questionnaires
KW  - Sampling Methods
KW  - Diagnosis, Psychosocial
KW  - Child Abuse, Sexual
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Bivariate Statistics
KW  - Logistic Regression
KW  - Ethnographic Research
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Male
KW  - Female
KW  - Human
SP  - 69
EP  - 89
JO  - Journal of Human Behavior in the Social Environment
JF  - Journal of Human Behavior in the Social Environment
JA  - J HUM BEHAV SOC ENVIRON
VL  - 2
IS  - 1/2
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - One of the defining characteristics of American Indian and Alaska Native communities is the removal of hundreds of thousands of children from their natural parents, extended families, and often, reservation environments. Though widely discussed, little is known about the sequelac of out-of-home placement among American Indians. In this paper we investigate the occurrence of out-of-home placement among 580 Southwestern American Indian tribal members. Out-of-home placement is examined here within a broad context of trauma, alcohol abuse and dependence, and other psychiatric disorders.
SN  - 1091-1359
AD  - Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Driscoll, Anne K.
AU  - Hearn, Gesine K.
AU  - Evans, V. Jeffery
AU  - Moore, Kristin A.
AU  - Sugland, Barbara W.
AU  - Call, Vaughn
T1  - Nonmarital Childbearing Among Adult Women.
JO  - Journal of Marriage & Family
JF  - Journal of Marriage & Family
Y1  - 1999/02//
VL  - 61
IS  - 1
M3  - Article
SP  - 178
EP  - 187
SN  - 00222445
AB  - We look at fertility and economic outcomes of women with three types of nonmarital births and women who have marital births. The sample is from the National Survey of Families and Households. Net of controls, married and unmarried women with a recent birth are equally likely to hare another birth. Never-married and previously married mothers are more likely to have another nonmarital birth than are other women. Additional nonmarital births to never-married women are associated with being on welfare, not being, employed, and having low household income. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - WOMEN
KW  - PREGNANCY
KW  - FERTILITY
KW  - SINGLE women
KW  - PARENTING
KW  - fertility history
KW  - marital fertility
KW  - nonmarital fertility
KW  - out-of-wedlock births
KW  - premarital fertility
N1  - Accession Number: 1606779; Driscoll, Anne K. 1; Email Address: adriscoll@childtrends.org Hearn, Gesine K. 2 Evans, V. Jeffery 2; Email Address: evansj@nichd.nih.gov Moore, Kristin A. 1; Email Address: kmoore@childtrends.org Sugland, Barbara W. 1; Email Address: bsugland@childtrends.org Call, Vaughn 3; Email Address: vaughn_call@byu.edu; Affiliation:  1: Child Trends  2: National Institute of Child Health and Human Development  3: Brigham Young University; Source Info: Feb99, Vol. 61 Issue 1, p178; Subject Term: WOMEN; Subject Term: PREGNANCY; Subject Term: FERTILITY; Subject Term: SINGLE women; Subject Term: PARENTING; Author-Supplied Keyword: fertility history; Author-Supplied Keyword: marital fertility; Author-Supplied Keyword: nonmarital fertility; Author-Supplied Keyword: out-of-wedlock births; Author-Supplied Keyword: premarital fertility; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6856
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sihag, Ram K
AU  - Jaffe, Howard
AU  - Nixon, Ralph A
AU  - Rong, Xianhui
T1  - Serine-23 Is a Major Protein Kinase A Phosphorylation Site on the Amino-Terminal Head Domain of the Middle Molecular Mass Subunit of Neurofilament Proteins.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/02//
VL  - 72
IS  - 2
M3  - Article
SP  - 491
EP  - 499
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Abstract : We have shown previously that phosphate groups on the amino-terminal head domain region of the middle molecular mass subunit of neurofilament proteins (NF-M) are added by second messenger-dependent protein kinases. Here, we have identified Ser23 as a specific protein kinase A phosphorylation site on the native NF-M subunit and on two synthetic peptides, S1 (14 RRVPTETRSSF24 ) and S2 (21 RSSFSRVSGSPSSGFRSQSWS41 ), localized within the amino-terminal head domain region. Ser23 was identified as a phosphorylation site on the 32 P-labeled α-chymotryptic peptide that carried >80% of the 32 P-phosphates incorporated into the NF-M subunit by protein kinase A. The synthetic peptides S1 and S2 were phosphorylated 18 and two times more efficiently by protein kinase A than protein kinase C, respectively. Neither of the peptides was phosphorylated by casein kinase II. The sequence analyses of the chemically modified phosphorylated serine residues showed that Ser23 was the major site of phosphorylation for protein kinase A on both S1 and S2 peptides. Low levels of incorporation of 32 P-phosphates into Ser22 , Ser28 , and Ser32 by protein kinase A were also observed. Protein kinase C incorporated 32 P-phosphates into Ser22 , Ser23 , Ser25 , Ser28 , Ser32 , and a threonine residue, but none of these sites could be assigned as a major site of phosphorylation. Analyses of the phosphorylated synthetic peptides by liquid chromatography-tandem mass spectrometry also showed that protein kinase A phosphorylated only one site on peptide S1 and that ions with up to four phosphates were detected on peptide S2 . Analysis of the data from the tandem ion trap mass spectrometry by... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SERINE
KW  - CYTOPLASMIC filaments
KW  - PROTEIN kinases
KW  - Mass spectrometry
KW  - Neurofilament protein
KW  - Phosphopeptides
KW  - Phosphorylation
KW  - Protein kinase A
N1  - Accession Number: 6270745; Sihag, Ram K 1,2 Jaffe, Howard 3,4 Nixon, Ralph A 2 Rong, Xianhui 2; Affiliation:  1: Neurobiology  2: Protein/Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland  3: Laboratories for Molecular Neuroscience, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, U.S.A.  4: Neurochemistry; Source Info: Feb99, Vol. 72 Issue 2, p491; Subject Term: SERINE; Subject Term: CYTOPLASMIC filaments; Subject Term: PROTEIN kinases; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Neurofilament protein; Author-Supplied Keyword: Phosphopeptides; Author-Supplied Keyword: Phosphorylation; Author-Supplied Keyword: Protein kinase A; Number of Pages: 9p; Illustrations: 2 Diagrams, 5 Charts, 2 Graphs; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0720491.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kapatos, Gregory
AU  - Hirayama, Kei
AU  - Shimoji, Mika
AU  - Milstien, Sheldon
T1  - GTP Cyclohydrolase I Feedback Regulatory Protein Is Expressed in Serotonin Neurons and Regulates Tetrahydrobiopterin Biosynthesis.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/02//
VL  - 72
IS  - 2
M3  - Article
SP  - 669
EP  - 675
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Abstract : Tetrahydrobiopterin, the coenzyme required for hydroxylation of phenylalanine, tyrosine, and tryptophan, regulates its own synthesis through feedback inhibition of GTP cyclohydrolase I (GTPCH) mediated by a regulatory subunit, the GTP cyclohydrolase feedback regulatory protein (GFRP). In the liver, L-phenylalanine specifically stimulates tetrahydrobiopterin synthesis by displacing tetrahydrobiopterin from the GTPCH-GFRP complex. To explore the role of this regulatory system in rat brain, we examined the localization of GFRP mRNA using double-label in situ hybridization. GFRP mRNA expression was abundant in serotonin neurons of the dorsal raphe nucleus but was undetectable in dopamine neurons of the midbrain or norepinephrine neurons of the locus coeruleus. Simultaneous nuclease protection assays for GFRP and GTPCH mRNAs showed that GFRP mRNA is most abundant within the brainstem and that the ratio of GFRP to GTPCH mRNA is much higher than in the ventral midbrain. Two species of GFRP mRNA differing by ~20 nucleotides in length were detected in brainstem but not in other tissues, with the longer, more abundant form being common to other brain regions. It is interesting that the pineal and adrenal glands did not contain detectable levels of GFRP mRNA, although GTPCH mRNA was abundant in both. Primary neuronal cultures were used to examine the role of GFRP-mediated regulation of GTPCH on tetrahydrobiopterin synthesis within brainstem serotonin neurons and midbrain dopamine neurons. L-Phenylalanine increased tetrahydrobiopterin levels in serotonin neurons to a maximum of twofold in a concentration-dependent manner, whereas D-phenylalanine and L-tryptophan were without effect. In contrast, tetrahydrobiopterin levels within cultured dopamine neurons were not altered by L-phenylalanine. The time course of this effect was very rapid, with a maximal response observed within 60 min. Inhibitors of tetrahydrobiopterin biosynthesis prevented the... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUANOSINE triphosphate
KW  - IN situ hybridization
KW  - TETRAHYDROBIOPTERIN
KW  - 5,6,7,8-Tetrahydrobiopterin
KW  - Dopamine
KW  - GTP cyclohydrolase I
KW  - GTP cyclohydrolase I feedback regulatory
KW  - protein
KW  - serotonin.
N1  - Accession Number: 6270726; Kapatos, Gregory Hirayama, Kei Shimoji, Mika Milstien, Sheldon 1; Affiliation:  1: Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland, U.S.A.; Source Info: Feb99, Vol. 72 Issue 2, p669; Subject Term: GUANOSINE triphosphate; Subject Term: IN situ hybridization; Subject Term: TETRAHYDROBIOPTERIN; Author-Supplied Keyword: 5,6,7,8-Tetrahydrobiopterin; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: GTP cyclohydrolase I; Author-Supplied Keyword: GTP cyclohydrolase I feedback regulatory; Author-Supplied Keyword: protein; Author-Supplied Keyword: serotonin.; Number of Pages: 7p; Illustrations: 1 Diagram, 5 Charts, 2 Graphs; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0720669.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Freudenheim, Jo L.
AU  - Sinha, Rashmi
T1  - Overview.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999/02//
VL  - 129
IS  - 2
M3  - Article
SP  - 550S
EP  - 551S
SN  - 00223166
N1  - Accession Number: 96711775; Freudenheim, Jo L. 1 Sinha, Rashmi 2; Affiliation:  1: Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214  2: Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892; Source Info: Feb99, Vol. 129 Issue 2, p550S; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cong Lai
AU  - Shields, Peter G.
T1  - The Role of Interindividual Variation in Human Carcinogenesis.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999/02//
VL  - 129
IS  - 2
M3  - Article
SP  - 552S
EP  - 555S
SN  - 00223166
AB  - The process of chemical carcinogenesis is a complex multistage process initiated by DNA damage in growth control genes. Carcinogens enter the body from a variety of sources, but most require metabolic activation before they can damage DNA. There are multiple protective processes that include detoxification and conjugation, DNA repair and programmed cell death. Most of these functions exhibit wide interindividual variation in the population and thus are thought to affect cancer risk. The role of gene-environment interactions is being explored, and current data indicate that genetic susceptibilities can modify carcinogen exposures from the diet and tobacco smoking, although much more data exist for the latter. This review addresses the relationships of human carcinogenesis to these interindividual differences of phase I, phase II and DNA repair enzymes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - carcinogen metabolism
KW  - carcinogenesis
KW  - epidemiology
KW  - genetic polymorphism
KW  - nutrition
N1  - Accession Number: 96711777; Cong Lai 1 Shields, Peter G. 1; Affiliation:  1: Molecular Epidemiology Section, Laboratory of Human Carcinogenesis, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892–4255; Source Info: Feb99, Vol. 129 Issue 2, p552S; Author-Supplied Keyword: carcinogen metabolism; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: genetic polymorphism; Author-Supplied Keyword: nutrition; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sinha, Rashmi
AU  - Caporaso, Neil
T1  - Diet, Genetic Susceptibility and Human Cancer Etiology.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999/02//
VL  - 129
IS  - 2
M3  - Article
SP  - 556S
EP  - 559S
SN  - 00223166
AB  - There is evidence that high penetrance hereditary genes cause a number of relatively uncommon tumors in the familial setting, whereas common cancers are influenced by multiple loci that alter susceptibility to cancer and other conditions. The latter category of genes are involved in the metabolism of carcinogens (activation, detoxification) as well as those that interact with dietary exposure. This paper will consider some of the basic principles in studying susceptibility genes and provide a few examples in which they interact with dietary components. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - cytochrome P4501A2
KW  - genotype
KW  - heterocyclic amines
KW  - inducible
KW  - MeIQx
KW  - N-acetyltransferase
KW  - phenotype
N1  - Accession Number: 96711779; Sinha, Rashmi 1 Caporaso, Neil 1; Affiliation:  1: Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892; Source Info: Feb99, Vol. 129 Issue 2, p556S; Author-Supplied Keyword: cytochrome P4501A2; Author-Supplied Keyword: genotype; Author-Supplied Keyword: heterocyclic amines; Author-Supplied Keyword: inducible; Author-Supplied Keyword: MeIQx; Author-Supplied Keyword: N-acetyltransferase; Author-Supplied Keyword: phenotype; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ambrosone, Christine B.
AU  - Coles, Brian F.
AU  - Freudenheim, Jo L.
AU  - Shields, Peter G.
T1  - Glutathione-S-transferase (GSTM1) Genetic Polymorphisms Do Not Affect Human Breast Cancer Risk, Regardless of Dietary Antioxidants.
JO  - Journal of Nutrition
JF  - Journal of Nutrition
Y1  - 1999/02//
VL  - 129
IS  - 2
M3  - Article
SP  - 565S
EP  - 568S
SN  - 00223166
AB  - Glutathione-S-transferases catalyze the detoxication of carcinogen metabolites and reactive oxygen species (ROS) produced through a number of mechanisms. Glutathione-S-transferase (GST) M1 is polymorphic, and the null allele results in a lack of enzyme activity. Because there are indications that ROS may be involved in breast carcinogenesis, we sought to determine whether the GSTM1 null allele was associated with increased breast cancer, particularly among women with lower consumption of dietary sources of a-tocopherol, carotenoids and ascorbic acid. In a study of diet and cancer in western New York, women with primary, incident, histologically confirmed breast cancer (n = 740) and community controls (n = 810) were interviewed and an extensive food-frequency questionnaire administered. A subset of these women provided a blood specimen. DNA was extracted and genotyping performed for GSTM1. Data were available for 279 cases and 340 controls. The null allele did not increase breast cancer risk, regardless of menopausal status. There were also no differences in associations between the polymorphism and risk among lower and higher consumers of dietary sources of antioxidants or smokers and nonsmokers. These results indicate that GSTM1 genetic polymorphisms are not associated with breast cancer risk, even in an environment low in antioxidant defenses. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - antioxidants
KW  - breast neoplasms
KW  - epidemiology/molecular
KW  - glutathione-S-transferase
KW  - oxidative stress
N1  - Accession Number: 96711791; Ambrosone, Christine B. 1 Coles, Brian F. 1 Freudenheim, Jo L. 2 Shields, Peter G. 3; Affiliation:  1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079  2: Department of Social & Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214  3: Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD 20892; Source Info: Feb99, Vol. 129 Issue 2, p565S; Author-Supplied Keyword: antioxidants; Author-Supplied Keyword: breast neoplasms; Author-Supplied Keyword: epidemiology/molecular; Author-Supplied Keyword: glutathione-S-transferase; Author-Supplied Keyword: oxidative stress; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yamazaki, Y.
AU  - Savva, M.
AU  - Mokotoff, M.
AU  - Oka, S.
AU  - Kleinman, H.K.
T1  - Enhanced cleavage of diaminopimelate-containing isopeptides by leucine aminopeptidase and matrix metalloproteinases in tumors: application to bioadhesive peptides.
JO  - Journal of Peptide Research
JF  - Journal of Peptide Research
Y1  - 1999/02//
VL  - 53
IS  - 2
M3  - Article
SP  - 177
EP  - 187
PB  - Wiley-Blackwell
SN  - 1397002X
AB  - We prepared (2S,6S)-Z-Dpm(Z)(OMe) (4) by protease-mediated hydrolysis of (R,R/S,S)-Z-Dpm(Z)(OMe)-OMe (3), converted it to (2S,6S)-Dpm(Z)(OMe) (6) via PCl[sub 5] to an NCA intermediate and hydrolysis, protected the amino group with Boc to give (2S,6S)-Boc-Dpm(Z)(OMe) (7), which upon ammonolysis of the Me ester afforded (2S,6S)-Boc-Dpm(Z)(NH[sub 2]) (8). Hydrogenolysis of 8 and protection with Fmoc gave (2S,6S)-Boc-Dpm(Fmoc)(NH[sub 2]) (10). Using 10 and SPPS, we prepared three Dpm-containing peptides and their corresponding Lys peptides. Enzymatic studies with mLAP and cLAP showed that the Leu moiety in Ac-Gly-(2S,6S)-Dpm(Leu)(NH[sub 2])-Ala (14) was hydrolyzed 68-fold and> 1000-fold more rapidly, respectively, than that in Ac-Gly-Lys(Leu)-Ala (12). The enhanced rate of Leu formation from 14 compared to 12 was also observed with homogenates of mouse C3 sarcomas. This homogenate also hydrolyzed Ac-Gly-(2S,6S)-Dpm(Ac-Gly-Pro-Gln-Gly-Leu)(NH[sub 2])-Ala (16) to Ac-Gly-(2S,6S)-Dpm(NH[sub 2])-Ala (13), Leu and Ac-Gly-Pro-Gln-Gly (17). This implies the side chain is cleaved first by endopeptidases, such as matrix metalloproteinases (MMPs), and then the remaining Leu is cleaved by LAP-like exopeptidases. The rate of liberation of 17 from 16 and the corresponding Lys isopeptide, Ac-Gly-Lys(Ac-Gly-Pro-Gln-Gly-Leu)-Ala (15), was not significantly different. The rate of formation of 13 was faster from 16 than Ac-Gly-Lys-Ala (11) was from 15. Thus, the entire isopeptide side chain can be removed by the cooperative action of LAP-like and MMP-like peptidases present in tumor tissue, which occurs faster in the Dpm peptide 16 than in the Lys peptide 15. The rate of formation of 13 from 16 by lung, liver, and intestine homogenates (from the same C3 tumor-bearing mice) was comparable to or higher than from the tumor homogenates, but the rate by blood was only 4% the value of the tumor homogenates. Analogs of a bioadhesive fragment from the laminin α1 chain were prepared by replacing the essential Lys with Dpm(NH[sub 2]) (20) and Dpm(Leu)(NH[sub 2]) (21). Both Dpm-containing peptides were active, although considerably weaker than the corresponding Lys peptides 18 and 19, in a cell attachment assay with human fibrosarcoma HT-1080 cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Peptide Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LEUCINE aminopeptidase
KW  - METALLOPROTEINASES
KW  - SARCOMA
KW  - C3 sarcoma homogenates
KW  - diaminopimelate-containing peptides
KW  - HT1080 attachment assay
KW  - isopeptides
KW  - leucine aminopeptidase
KW  - matrix metalloproteinases
KW  - peptide-prodrugs
N1  - Accession Number: 5169203; Yamazaki, Y. 1 Savva, M. 1 Mokotoff, M. 1 Oka, S. 2 Kleinman, H.K. 3; Affiliation:  1: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA  2: National Institute of bioscience and Human Technology, Agency of Industrial Science and Technology, Tsukube, Ibaraki 305, Japan.  3: National Institute of Dental Research, National Institutes of Health, Bethesda, MD20892, USA; Source Info: Feb99, Vol. 53 Issue 2, p177; Subject Term: LEUCINE aminopeptidase; Subject Term: METALLOPROTEINASES; Subject Term: SARCOMA; Author-Supplied Keyword: C3 sarcoma homogenates; Author-Supplied Keyword: diaminopimelate-containing peptides; Author-Supplied Keyword: HT1080 attachment assay; Author-Supplied Keyword: isopeptides; Author-Supplied Keyword: leucine aminopeptidase; Author-Supplied Keyword: matrix metalloproteinases; Author-Supplied Keyword: peptide-prodrugs; Number of Pages: 11p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - RACUSEN, LORRAINE C.
AU  - SOLEZ, KIM
AU  - COLVIN, ROBERT B.
AU  - BONSIB, STEPHEN M.
AU  - CASTRO, MARIA C.
AU  - CAVALLO, TITO
AU  - CROKER, BYRON P.
AU  - DEMETRIS, A. JAKE
AU  - DRACHENBERG, CYNTHIA B.
AU  - FOGO, AGNES B.
AU  - FURNESS, PETER
AU  - GABER, LILLIAN W.
AU  - GIBSON, IAN W.
AU  - GLOTZ, DENNIS
AU  - GOLDBERG, JULIO C.
AU  - GRANDE, JOSEPH
AU  - HALLORAN, PHILIP F.
AU  - HANSEN, H. E.
AU  - HARTLEY, BARRY
AU  - HAYRY, PEKKA J.
T1  - The Banff 97 working classification of renal allograft pathology.
JO  - Kidney International
JF  - Kidney International
Y1  - 1999/02//
VL  - 55
IS  - 2
M3  - Article
SP  - 713
EP  - 723
SN  - 00852538
AB  - The Banff 97 working classification of renal allograft pathology. Background. Standardization of renal allograft biopsy interpretation is necessary to guide therapy and to establish an objective end point for clinical trials. This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology. Methods. Banff 97 grew from an international consensus discussion begun at Banff and continued via the Internet. This schema developed from (a ) analysis of data using the Banff classification, (b ) publication of and experience with the CCTT modification, (c ) international conferences, and (d ) data from recent studies on impact of vasculitis on transplant outcome. Results. Semiquantitative lesion scoring continues to focus on tubulitis and arteritis but includes a minimum threshold for interstitial inflammation. Banff 97 defines “types” of acute/active rejection. Type I is tubulointerstitial rejection without arteritis. Type II is vascular rejection with intimal arteritis, and type III is severe rejection with transmural arterial changes. Biopsies with only mild inflammation are graded as “borderline/suspicious for rejection.” Chronic/sclerosing allograft changes are graded based on severity of tubular atrophy and interstitial fibrosis. Antibody-mediated rejection, hyperacute or accelerated acute in presentation, is also categorized, as are other significant allograft findings. Conclusions. The Banff 97 working classification refines earlier schemas and represents input from two classifications most widely used in clinical rejection trials and in clinical practice worldwide. Major changes include the following: rejection with vasculitis is separated from tubulointerstitial rejection; severe rejection requires transmural changes in arteries; “borderline” rejection can only be... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HOMOGRAFTS
KW  - BIOPSY
KW  - CLINICAL trials
KW  - allograft pathology
KW  - biopsy interpretation
KW  - kidney
KW  - Lesion scoring
KW  - transplantation
N1  - Accession Number: 5879788; RACUSEN, LORRAINE C. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 SOLEZ, KIM 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 COLVIN, ROBERT B. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 BONSIB, STEPHEN M. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 CASTRO, MARIA C. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 CAVALLO, TITO 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 CROKER, BYRON P. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 DEMETRIS, A. JAKE 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 DRACHENBERG, CYNTHIA B. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 FOGO, AGNES B. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 FURNESS, PETER 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 GABER, LILLIAN W. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 GIBSON, IAN W. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 GLOTZ, DENNIS 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 GOLDBERG, JULIO C. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 GRANDE, JOSEPH 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 HALLORAN, PHILIP F. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 HANSEN, H. E. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 HARTLEY, BARRY 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 HAYRY, PEKKA J. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31; Affiliation:  1: The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA,  2: University of Alberta, Edmonton, Alberta, Canada,  3: Massachusetts General Hospital, Boston, Massachusetts,  4: University of Arkansas, Little Rock, Arkansas, USA,  5: São Paulo University, São Paulo, Brazil,  6: University of Cincinnati, Cincinnati, Ohio,  7: University of Florida, Gainesville, Florida,  8: University of Pittsburgh, Pittsburgh, Pennsylvania,  9: University of Maryland, Baltimore, Maryland,  10: Vanderbilt University, Nashville, Tennessee, USA,  11: University of Leicester, Leicester, England, United Kingdom,  12: University of Tennessee, Memphis, Tennessee, USA,  13: University of Glasgow, Glasgow, Scotland, United Kingdom,  14: Hopital Broussais, Paris, France,  15: Institute of Pathology, Buenos Aires, Argentina,  16: Mayo Clinic, Rochester, Minnesota, USA,  17: University of Aarhus, Aarhus, Denmark,  18: Guys and St. Thomas Hospital, London, England, United Kingdom,  19: University of Helsinki, Helsinki, Finland,  20: Queens University, Belfast, Ireland, United Kingdom,  21: Louisiana State University, New Orleans, Louisiana,  22: University of Iowa, Iowa City, Iowa,  23: EMMES Corp., Potomac, Maryland, USA,  24: University of Basel, Basel, Switzerland,  25: University of Manitoba, Manitoba, Winnipeg, Canada,  26: University of Manchester, Manchester, England, United Kingdom,  27: National Institutes of Health, NIAID, Bethesda, Maryland,  28: St. Louis University, St. Louis, Missouri,  29: Scripps Institute, La Jolla, California, USA,  30: National Hospital, Oslo, Norway,  31: Jikel University, Chiba-Ken, Japan; Source Info: Feb1999, Vol. 55 Issue 2, p713; Subject Term: HOMOGRAFTS; Subject Term: BIOPSY; Subject Term: CLINICAL trials; Author-Supplied Keyword: allograft pathology; Author-Supplied Keyword: biopsy interpretation; Author-Supplied Keyword: kidney; Author-Supplied Keyword: Lesion scoring; Author-Supplied Keyword: transplantation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Illustrations: 14 Charts; Document Type: Article
L3  - 10.1046/j.1523-1755.1999.00299.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5879788&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Hoffmann, Bernd
AU  - Mösch, Hans-Ulrich
AU  - Sattlegger, Evelyn
AU  - Barthelmess, Ilse Babette
AU  - Hinnebusch, Alan
AU  - Braus, Gerhard H
T1  - The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino-acid starvation.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1999/02//
VL  - 31
IS  - 3
M3  - Article
SP  - 807
EP  - 822
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - The CPC2 gene of the budding yeast Saccharomyces cerevisiae encodes a Gβ-like WD protein which is involved in regulating the activity of the general control activator Gcn4p. The CPC2 gene encodes a premRNA which is spliced and constitutively expressed in the presence or absence of amino acids. Loss of CPC2 gene function suppresses a deletion of the GCN2 gene encoding the general control sensor kinase, but not a deletion in the GCN4 gene. The resulting phenotype has resistance against amino-acid analogues. The Neurospora crassa cpc-2 and the rat RACK1 genes are homologues of CPC2 that complement the yeast cpc2 deletion. The cpc2Δ mutation leads to increased transcription of Gcn4p-dependent genes under non-starvation conditions without increasing GCN4 expression or the DNA binding activity of Gcn4p. Cpc2p-mediated transcriptional repression requires the Gcn4p transcriptional activator and a Gcn4p recognition element in the target promoter. Frameshift mutations resulting in a shortened Gβ-like protein cause a different phenotype that has sensitivity against amino-acid analogues similar to a gcn2 deletion. Cpc2p seems to be part of an additional control of Gcn4p activity, independent of its translational regulation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Saccharomyces cerevisiae
KW  - Amino acids
KW  - Phenotype
N1  - Accession Number: 6010826; Hoffmann, Bernd 1; Mösch, Hans-Ulrich 1; Sattlegger, Evelyn 2; Barthelmess, Ilse Babette 3; Hinnebusch, Alan 2; Braus, Gerhard H 1; Affiliations: 1: Institute for Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D-037077 Göttingen, Germany.,; 2: Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.,; 3: Institute for Applied Genetics, University of Hannover, Herrenhäuser Str. 2, D-30419 Hannover, Germany.; Issue Info: Feb99, Vol. 31 Issue 3, p807; Subject Term: Saccharomyces cerevisiae; Subject Term: Amino acids; Subject Term: Phenotype; Number of Pages: 16p; Illustrations: 6 Black and White Photographs, 3 Charts, 6 Graphs; Document Type: Article
L3  - 10.1046/j.1365-2958.1999.01219.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=6010826&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Ohsaki, Yoshinobu
AU  - Gross, Andrew J.
AU  - Le, Phuong Tram
AU  - Oie, Herbert
AU  - Johnson, Bruce E.
T1  - Human Small Cell Lung Cancer Cells Produce Brain Natriuretic Peptide.
JO  - Oncology
JF  - Oncology
Y1  - 1999/02//
VL  - 56
IS  - 2
M3  - Article
SP  - 155
EP  - 159
SN  - 00302414
AB  - The tumoral production of brain natriuretic peptide (BNP) was studied using 9 small cell lung cancer (SCLC) cell lines which were established from patients with small cell lung cancer. BNP cDNA fragment was generated from 20 µg total RNA which was prepared from the human right cardiac atrium by reverse transcription-based polymerase chain reaction. Expression of BNP mRNA was detected in 30 µg total cellular RNA from these cell lines by RNase protection assays in 5 of 9 SCLC cell lines. Radioimmunoassays using [sup 125] I-radiolabeled human BNP(1–32) and antihuman BNP(1–32) antibody detected immunoreactivity in cell pellets from SCLC cell lines which had detectable BNP mRNA. BNP immunoreactivity in the cell pellets corresponds with the data from BNP mRNA analyses. We conclude that SCLC cells have detectable BNP mRNA by RNase protection assay and BNP immunoreactivity in the cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LUNGS -- Cancer
KW  - CANCER cells
KW  - PEPTIDES
KW  - POLYMERASE chain reaction
KW  - RADIOIMMUNOASSAY
KW  - MESSENGER RNA
KW  - Brain natriuretic peptide
KW  - Ectopic hormone syndromes
KW  - Lung neoplasm
KW  - Small cell lung cancer
N1  - Accession Number: 11375983; Ohsaki, Yoshinobu 1 Gross, Andrew J. 1 Le, Phuong Tram 1 Oie, Herbert 1 Johnson, Bruce E. 1; Affiliation:  1: NCI-Navy Medical Oncology Branch, National Cancer Institute, National Institutes of Health, National Naval Medical Center, Bethesda, Md., USA; Source Info: 1999, Vol. 56 Issue 2, p155; Subject Term: LUNGS -- Cancer; Subject Term: CANCER cells; Subject Term: PEPTIDES; Subject Term: POLYMERASE chain reaction; Subject Term: RADIOIMMUNOASSAY; Subject Term: MESSENGER RNA; Author-Supplied Keyword: Brain natriuretic peptide; Author-Supplied Keyword: Ectopic hormone syndromes; Author-Supplied Keyword: Lung neoplasm; Author-Supplied Keyword: Small cell lung cancer; Number of Pages: 5p; Illustrations: 1 Black and White Photograph, 2 Charts; Document Type: Article
L3  - 10.1159/000011957
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11375983&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104714832
T1  - Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain.
AU  - Benoliel, R
AU  - Eliav, E
AU  - Mannes, A J
AU  - Caudle, R M
AU  - Leeman, S
AU  - Iadarola, M J
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 104714832. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Bacterial Toxins
KW  - Pain -- Drug Therapy
KW  - Recombinant Proteins -- Therapeutic Use
KW  - Neurotransmitter Agents
KW  - Acute Disease
KW  - Animals
KW  - Polysaccharides
KW  - Chronic Disease
KW  - Constriction, Pathologic -- Physiopathology
KW  - Hyperalgesia -- Pathology
KW  - Hyperalgesia -- Physiopathology
KW  - Immunohistochemistry
KW  - Inflammation -- Chemically Induced
KW  - Inflammation -- Drug Therapy
KW  - Inflammation -- Pathology
KW  - Injections, Intraspinal
KW  - Male
KW  - Pain -- Pathology
KW  - Pain Measurement
KW  - Rats
KW  - Recombinant Proteins -- Administration and Dosage
KW  - Sciatic Nerve -- Physiopathology
SP  - 243
EP  - 253
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 79
IS  - 2-3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Neuronal Gene Expression Unit, Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4410, USA.
U2  - PMID: 10068170.
DO  - 10.1016/S0304-3959(98)00170-5
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104714832&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104714831
T1  - The kappa opioid agonist GR89,696 blocks hyperalgesia and allodynia in rat models of peripheral neuritis and neuropathy.
AU  - Eliav, E
AU  - Herzberg, U
AU  - Caudle, R M
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 104714831. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686. 
KW  - Analgesics, Nonnarcotic -- Therapeutic Use
KW  - Heterocyclic Compounds -- Therapeutic Use
KW  - Hyperalgesia -- Drug Therapy
KW  - Neuritis -- Drug Therapy
KW  - Pain -- Drug Therapy
KW  - Peripheral Nervous System Diseases -- Drug Therapy
KW  - Peripheral Nervous System -- Physiopathology
KW  - Receptors, Cell Surface
KW  - Animal Studies
KW  - Cold -- Adverse Effects
KW  - Heat -- Adverse Effects
KW  - Hyperalgesia -- Physiopathology
KW  - Injections, Intraspinal
KW  - Male
KW  - Neuritis -- Physiopathology
KW  - Pain Measurement
KW  - Pain -- Physiopathology
KW  - Peripheral Nervous System Diseases -- Physiopathology
KW  - Physical Stimulation
KW  - Rats
KW  - Sciatic Nerve -- Physiopathology
KW  - Skin -- Innervation
SP  - 255
EP  - 264
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 79
IS  - 2-3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4410, USA.
U2  - PMID: 10068171.
DO  - 10.1016/S0304-3959(98)00177-8
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104714831&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107182328
T1  - Osteopenia in the patient with cancer.
AU  - Croarkin E
Y1  - 1999/02//
N1  - Accession Number: 107182328. Language: English. Entry Date: 19990501. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0022623. 
KW  - Neoplasms -- Complications
KW  - Bone Diseases, Metabolic
KW  - Bone Density
KW  - Bone Diseases, Metabolic -- Etiology
KW  - Homeostasis
SP  - 196
EP  - 201
JO  - Physical Therapy
JF  - Physical Therapy
JA  - PHYS THER
VL  - 79
IS  - 2
CY  - Alexandria, Virginia
PB  - American Physical Therapy Association
SN  - 0031-9023
AD  - Physical Therapist, Warren G Magnuson Clinical Center, National Institutes of Health, Bldg 10, Room 6S-235, Bethesda, MD 20892-1604; e-mail: earllaine_simpler@nih.gov
U2  - PMID: 10029059.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107182328&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107195091
T1  - Psychosocial, school, and parent factors associated with recent smoking among early-adolescent boys and girls.
AU  - Simons-Morton B
AU  - Crump AD
AU  - Haynie DL
AU  - Saylor KE
AU  - Eitel P
AU  - Yu K
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 107195091. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: NIH Contract N01-HD-4-3207. NLM UID: 0322116. 
KW  - Adolescent Behavior
KW  - Smoking -- Epidemiology -- In Adolescence
KW  - Adolescence
KW  - Adolescent Psychology
KW  - Child
KW  - Family Health
KW  - Female
KW  - Male
KW  - Maryland
KW  - Parents -- Psychosocial Factors
KW  - Peer Group
KW  - Prevalence
KW  - Self-Efficacy
KW  - Smoking -- Psychosocial Factors
KW  - Whites
KW  - Blacks
KW  - Peer Pressure
KW  - Race Factors
KW  - Parent-Child Relations
KW  - Factor Analysis
KW  - Multiple Logistic Regression
KW  - Questionnaires
KW  - Independent Variable
KW  - Dependent Variable
KW  - Self Report
KW  - Data Analysis Software
KW  - Funding Source
KW  - P-Value
KW  - Descriptive Statistics
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Human
SP  - 138
EP  - 148
JO  - Preventive Medicine
JF  - Preventive Medicine
JA  - PREV MED
VL  - 28
IS  - 2
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
AB  - BACKGROUND: Experimentation with smoking often begins during adolescence, but an adequate understanding of the factors associated with early initiation remains elusive. METHODS: Sixth- to eighth-grade students (n = 4,263, 67.1% white, 23.5% black, 7.2% other) from seven middle schools were surveyed. RESULTS: The overall prevalence of recent smoking (past 30 days) of 10.4% was similar for boys and girls and by race, but increased from 3.7% in sixth to 17.8% in eighth grade. In multiple logistic regression analyses positive outcome expectations, high perceived prevalence, deviance acceptance, and trouble at school were independently associated with smoking for both boys and girls. Among boys, problem-behaving friends, peer pressure, authoritative parenting, and mother's education and among girls, self-control problems, knowledgeable parents, and grade were independently associated with smoking. CONCLUSIONS: This is one of the few studies to report an independent association between smoking and outcome expectations, the first study to report an independent effect for peer influences among boys only, and one of several to find a negative association between smoking and positive parenting behavior. These findings suggest that the effectiveness of preventive interventions might be improved by targeting parent, school, and student outcomes, including outcome expectations, deviance acceptance, and social norms for both boys and girls, peer influences among boys, and self-control among girls.
SN  - 0091-7435
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 10048105.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107195091&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107195105
T1  - Comparison of risk estimates for selected diseases and causes of death.
AU  - Merrill RM
AU  - Kessler LG
AU  - Udler JM
AU  - Rasband GC
AU  - Feuer EJ
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 107195105. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0322116. 
KW  - Chronic Disease -- Epidemiology -- United States
KW  - Death -- Etiology
KW  - Adult
KW  - Aged
KW  - Aged, 80 and Over
KW  - Age Factors
KW  - Whites
KW  - Models, Statistical
KW  - Descriptive Statistics
KW  - Life Table Method
KW  - Comparative Studies
KW  - Female
KW  - Forecasting
KW  - Incidence
KW  - Male
KW  - Middle Age
KW  - Blacks
KW  - Risk Assessment
KW  - Sex Factors
KW  - United States
KW  - Human
SP  - 179
EP  - 193
JO  - Preventive Medicine
JF  - Preventive Medicine
JA  - PREV MED
VL  - 28
IS  - 2
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
AB  - BACKGROUND: Lifetime risk estimates of disease are limited by long-term data extrapolations and are less relevant to individuals who have already lived a period of time without the disease, but are approaching the age at which the disease risk becomes common. In contrast, short-term age-conditional risk estimates, such as the risk of developing a disease in the next 10 years among those alive and free of the disease at a given age, are less restricted by long-term extrapolation of current rates and can present patients with risk information tailored to their age. This study focuses on short-term age-conditional risk estimates for a broad set of important chronic diseases and nondisease causes of death among white and black men and women. METHODS: The Feuer et al. (1993, Journal of the National Cancer Institute) [15] method was applied to data from a variety of sources to obtain risk estimates for select cancers, myocardial infarction, diabetes mellitus, multiple sclerosis, Alzheimer's, and death from motor vehicle accidents, homicide or legal intervention, and suicide. RESULTS: Acute deaths from suicide, homicide or legal intervention, and fatal motor vehicle accidents dominate the risk picture for persons in their 20s, with only diabetes mellitus and end-stage renal disease therapy (for blacks only) having similar levels of risk in this age range. Late in life, cancer, acute myocardial infarction, Alzheimer's, and stroke become most common. The chronic diseases affecting the population later in life present the most likely diseases someone will face. Several interesting differences in disease and death risks were derived and reported among age-specific race and gender subgroups of the population. CONCLUSION: Presentation of risk estimates for a broad set of chronic diseases and nondisease causes of death within short-term age ranges among population subgroups provides tailored information that may lead to better educated prevention, screening, and control behaviors and more efficient allocation of health resources.
SN  - 0091-7435
AD  - Cancer Control Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892-7344
U2  - PMID: 10048110.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107195105&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107187685
T1  - Molecular genetics of gastrointestinal malignancies.
AU  - Glaser E
AU  - Grogan L
Y1  - 1999/02//1999 Feb
N1  - Accession Number: 107187685. Language: English. Entry Date: 19990501. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Gastrointestinal Neoplasms
KW  - Genetics
KW  - Oncogenes
KW  - Colorectal Neoplasms -- Familial and Genetic
KW  - Risk Factors
KW  - Pancreatic Neoplasms
KW  - Esophageal Neoplasms
KW  - Stomach Neoplasms
KW  - Carcinoma, Hepatocellular
KW  - Gastrointestinal Neoplasms -- Physiopathology
KW  - Mutation
SP  - 3
EP  - 9
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 15
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To review the genetic model of colon cancer formation and the primary advances and clinical relevance of molecular genetics of pancreatic cancer and other gastrointestinal malignancies. DATA SOURCES: Research studies, review articles, and textbook chapters. CONCLUSIONS: Genetic discoveries are influencing the screening and treatment of colorectal cancer and other gastrointestinal malignancies by better targeting chemoprevention and treatment in high-risk and molecular-distinct patient populations. IMPLICATIONS FOR NURSING PRACTICE: A basic knowledge of cancer genetics and the latest genetic discoveries will assist oncology nurses in patient teaching, counseling, and care. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0749-2081
AD  - National Cancer Institute, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD
U2  - PMID: 10074652.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Bih Fang Pan
AU  - Sweet, Douglas H.
AU  - Pritchard, John B.
AU  - Rong Chen
AU  - Nelson, J. Arly
T1  - In vitro toxicology and alternative testing. A transfected cell model for the renal toxin transporter, rOCT2.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/02//
VL  - 47
IS  - 2
M3  - Article
SP  - 181
EP  - 186
PB  - Oxford University Press / USA
SN  - 10966080
AB  - a cDNA for the organic cation transporter (rOCT2) of the rat kidney was inserted into the retroviral plasmid pLXSN. This plasmid was used to stably transfect NIH3T3 cells. The transfected cell line exhibited an enhanced rate of tetraethylammonium (TEA) uptake and efflux compared to wild-type HNIH3T3 cells. Uptake of TEA by the transfected cells was markedly reduced upon incubation at 4°C. When the extracellular pH was lowered from 8.1 to 5.9, uptake was also reduced, suggesting inhibition of rOCT2 by extracellular protons. The apparent Km for TEA in the transfected cells was 141 μM. The classical organic cation transport inhibitors, cyanine 863 and cimetidine, produced noncompetitive inhibition with apparent Ki values of 0.81 and 198 μM, respectively. Daunomycin, vinblastine, and the deoxyadenosine analogs, 2'-deoxytubercidin and 2-chlorodeoxyadenosine, did not appear to be substrates for rOCT2. However, the anticancer drug, cisplatin, competitively inhibited TEA uptake by rOCT2 with an apparent Ki value of 925 μM, suggesting that rOCT2 may play a role in its renal secretion. In summary, transfected NIH3T3 cells provide a facile system by which this and other organic ion transporters can be studied. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cisplatin
KW  - Daunomycin
KW  - Vinblastine
KW  - Antineoplastic agents
KW  - Kidneys
KW  - Rats as laboratory animals
KW  - 2′-deoxytubercidin
KW  - 2-chlorodeoxyadenosine
KW  - cisplatin
KW  - daunomycin
KW  - organic cation transport
KW  - rat kidney
KW  - tetraethylammonium
KW  - vinblastine
N1  - Accession Number: 44405714; Bih Fang Pan 1; Sweet, Douglas H. 2; Pritchard, John B. 2; Rong Chen 1; Nelson, J. Arly 1; Email Address: anelson@mdacc.tmc.edu; Affiliations: 1: Department of Experimental Pediatrics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030; 2: Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: Feb1999, Vol. 47 Issue 2, p181; Subject Term: Cisplatin; Subject Term: Daunomycin; Subject Term: Vinblastine; Subject Term: Antineoplastic agents; Subject Term: Kidneys; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: 2′-deoxytubercidin; Author-Supplied Keyword: 2-chlorodeoxyadenosine; Author-Supplied Keyword: cisplatin; Author-Supplied Keyword: daunomycin; Author-Supplied Keyword: organic cation transport; Author-Supplied Keyword: rat kidney; Author-Supplied Keyword: tetraethylammonium; Author-Supplied Keyword: vinblastine; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Morgan, Daniel L.
AU  - Mahler, Joel F.
AU  - Kirkpatrick, Daniel T.
AU  - Price, Herman C.
AU  - O'Connor, Robert W.
AU  - Wilson, Ralph E.
AU  - Moorman, Michael P.
T1  - Risk assessment. Characterization of inhaled α-methylstyrene vapor toxicity for B6C3F1 mice and F344 rats.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/02//
VL  - 47
IS  - 2
M3  - Article
SP  - 187
EP  - 194
PB  - Oxford University Press / USA
SN  - 10966080
AB  - α-Methylstyrene (AMS) is a chemical intermediate used in the synthesis of speciality polymers and copolymers. Inhalation studies of AMS were conducted because of the lack of toxicity data and the structural similarity of AMS to styrene, a toxic and potentially carcinogenic chemical. Male and female B6C3F1 mice were exposed to 0, 600, 800, or 1000 ppm AMS 6 h/day, 5 days/week, for 12 days. After 1 exposure, 21% (5/24) of female mice were found dead in the 1000-ppm group, 56% (10/18) in the 800-ppm group, and 6% (1/18) in the 600-ppm concentration group. After 12 exposures, relative liver weights were significantly increased and relative spleen weights were significantly decreased in both male and female mice at all concentrations. No microscopic treatment-related lesions were observed. A decrease in hepatic glutathione (GSH) was associated with AMS exposure for 1 and 5 days. Male and female F344 rats were exposed to 0, 600 or 1000 ppm AMS for 12 days. No mortality or sedation occurred in AMS-exposed rats. Relative liver weights were significantly increased in both males and females after 12 exposures to 600 or 1000 ppm. An increased hyaline droplet accumulation was detected in male rats in both concentration groups; no significant microscopic lesions were observed in other tissues examined. Exposure of male and female F344 rats and male NBR rats to 0, 125, 250 or 500 ppm AMS, 6 h/day for 9 days resulted in increased accumulation of hyaline droplets in the renal tubules of male F344 rats in the 250 and 500 ppm concentration groups. Although AMS and styrene are structurally very similar, AMS was considerably less toxic for mice and more toxic for male rats than styrene. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Epoxy compounds
KW  - Carcinogens
KW  - Styrene
KW  - Hyaline membrane disease
KW  - Kidney diseases
KW  - α-methylstyrene
KW  - epoxides
KW  - hyaline droplet nephropathy
KW  - styrene
N1  - Accession Number: 44405715; Morgan, Daniel L. 1; Email Address: morgand@niehs.nih.gov; Mahler, Joel F. 1; Kirkpatrick, Daniel T. 2; Price, Herman C. 2; O'Connor, Robert W. 2; Wilson, Ralph E. 1; Moorman, Michael P. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: ManTech Environmental Technology, Inc., Research Triangle Park, North Carolina 27709; Issue Info: Feb1999, Vol. 47 Issue 2, p187; Thesaurus Term: Epoxy compounds; Thesaurus Term: Carcinogens; Subject Term: Styrene; Subject Term: Hyaline membrane disease; Subject Term: Kidney diseases; Author-Supplied Keyword: α-methylstyrene; Author-Supplied Keyword: epoxides; Author-Supplied Keyword: hyaline droplet nephropathy; Author-Supplied Keyword: styrene; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-42404-011
AN  - 2015-42404-011
AU  - Kim, Manho
AU  - Lee, H.-S.
AU  - LaForet, Genevieve
AU  - McIntyre, Charmian
AU  - Martin, Eileen J.
AU  - Chang, Patrick
AU  - Kim, Tae Wan
AU  - Williams, M.
AU  - Reddy, P. H.
AU  - Tagle, Dan
AU  - Boyce, Frederick M.
AU  - Won, Lisa
AU  - Heller, Alfred
AU  - Aronin, Neil
AU  - DiFiglia, Marian
T1  - Mutant huntingtin expression in clonal striatal cells: Dissociation of inclusion formation and neuronal survival by caspase inhibition.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/02//
VL  - 19
IS  - 3
SP  - 964
EP  - 973
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - DiFiglia, Marian, Laboratory of Cellular Neurobiology, Massachusetts General Hospital, MGH-East, 149 13th Street, Charlestown, MA, US, 02129
N1  - Accession Number: 2015-42404-011. PMID: 9920660 Partial author list: First Author & Affiliation: Kim, Manho; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: DiFiglia, Marian. Major Descriptor: Apoptosis; Huntingtons Disease; Mutations. Minor Descriptor: Brain; Mice. Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Feb, 1999. Publication History: Accepted Date: Nov 20, 1998; Revised Date: Nov 18, 1998; First Submitted Date: Sep 21, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Neuronal intranuclear inclusions are found in the brains of patients with Huntington’s disease and form from the polyglutamine-expanded N-terminal region of mutant huntingtin. To explore the properties of inclusions and their involvement in cell death, mouse clonal striatal cells were transiently transfected with truncated and full-length human wild-type and mutant huntingtin cDNAs. Both normal and mutant proteins localized in the cytoplasm, and infrequently, in dispersed and perinuclear vacuoles. Only mutant huntingtin formed nuclear and cytoplasmic inclusions, which increased with polyglutamine expansion and with time after transfection. Nuclear inclusions contained primarily cleaved N-terminal products, whereas cytoplasmic inclusions contained cleaved and larger intact proteins. Cells with wild-type or mutant protein had distinct apoptotic features (membrane blebbing, shrinkage, cellular fragmentation), but those with mutant huntingtin generated the most cell fragments (apoptotic bodies). The caspase inhibitor Z-VAD-FMK significantly increased cell survival but did not diminish nuclear and cytoplasmic inclusions. In contrast, Z-DEVD-FMK significantly reduced nuclear and cytoplasmic inclusions but did not increase survival. A series of N-terminal products was formed from truncated normal and mutant proteins and from full-length mutant huntingtin but not from fulllength wild-type huntingtin. One prominent N-terminal product was blocked by Z-VAD-FMK. In summary, the formation of inclusions in clonal striatal cells corresponds to that seen in the HD brain and is separable from events that regulate cell death. N-terminal cleavage may be linked to mutant huntingtin’s role in cell death. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - NH2-terminal huntingtin fragments
KW  - nuclear inclusions
KW  - cytoplasmic inclusions
KW  - full-length huntingtin
KW  - apoptosis
KW  - apoptotic bodies
KW  - membrane blebbing
KW  - Z-VAD-FMK
KW  - Z-DEVDFMK
KW  - striatal hybrid cells
KW  - 1999
KW  - Apoptosis
KW  - Huntingtons Disease
KW  - Mutations
KW  - Brain
KW  - Mice
KW  - 1999
U1  - Sponsor: National Institutes of Health, US. Grant: NS16367. Recipients: DiFiglia, Marian
U1  - Sponsor: National Institutes of Health, US. Grant: NS31579. Recipients: DiFiglia, Marian; Aronin, Neil
U1  - Sponsor: Hereditary Disease Foundation. Recipients: DiFiglia, Marian; Aronin, Neil
U1  - Sponsor: Huntington’s Disease Society of America, US. Recipients: DiFiglia, Marian
U1  - Sponsor: Howard Hughes Medical Institute. Recipients: LaForet, Genevieve
U1  - Sponsor: Sponsor name not included. Grant: MH28942. Recipients: Heller, Alfred; Won, Lisa
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107182750
T1  - Estrogen replacement therapy and breast cancer survival in a large screening study.
AU  - Schairer C
AU  - Gail M
AU  - Byrne C
AU  - Rosenberg PS
AU  - Sturgeon SR
AU  - Brinton LA
AU  - Hoover RN
Y1  - 1999/02/03/
N1  - Accession Number: 107182750. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089. 
KW  - Hormone Replacement Therapy
KW  - Breast Neoplasms -- Mortality
KW  - Postmenopause
KW  - Breast Neoplasms -- Pathology
KW  - Time Factors
KW  - Survival Analysis
KW  - Risk Factors
KW  - Cox Proportional Hazards Model
KW  - Chi Square Test
KW  - Odds Ratio
KW  - Data Analysis Software
KW  - Confidence Intervals
KW  - Questionnaires
KW  - Human
SP  - 264
EP  - 270
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 3
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, EPN, Rm. 443, 6130 Executive Blvd., MSC 7374, Bethesda, MD 20892-7374; e-mail: Schairec@epndce.nci.nih.gov
U2  - PMID: 10037105.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107205266
T1  - Midlife hand grip strength as a predictor of old age disability.
AU  - Rantanen T
AU  - Guralnik JM
AU  - Foley D
AU  - Masaki K
AU  - Leveille S
AU  - Curb JD
AU  - White L
AU  - Rantanen, T
AU  - Guralnik, J M
AU  - Foley, D
AU  - Masaki, K
AU  - Leveille, S
AU  - Curb, J D
AU  - White, L
Y1  - 1999/02/10/
N1  - Accession Number: 107205266. Language: English. Entry Date: 19990801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Slawson D. Can hand grip muscle strength during midlife predict old age functional ability? (EVID BASED PRACT) 1999 May; 2 (5): 11-insert 2p. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Activities of Daily Living
KW  - Aging -- Physiology
KW  - Disabled
KW  - Grip Strength
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Prospective Studies
KW  - Risk Factors
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Human
SP  - 558
EP  - 560
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 281
IS  - 6
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Poor muscle strength, functional limitations, and disability often coexist, but whether muscle strength during midlife predicts old age functional ability is not known.Objective: To determine whether hand grip strength measured during midlife predicts old age functional limitations and disability in initially healthy men.Design and Setting: A 25-year prospective cohort study, the Honolulu Heart Program, which began in 1965 among Japanese-American men living on Oahu, Hawaii.Participants: A total of 608945- to 68-year-old men who were healthy at baseline and whose maximal hand grip strength was measured from 1965 through 1970. Altogether, 2259 men died over the follow-up period and 3218 survivors participated in the disability assessment in 1991 through 1993.Main Outcome Measures: Functional limitations including slow customary walking speed (< or =0.4 m/s) and inability to rise from a seated position without using the arms, and multiple self-reported upper extremity, mobility, and self-care disability outcomes.Results: After adjustment for multiple potential confounders, risk of functional limitations and disability 25 years later increased as baseline hand grip strength, divided into tertiles, declined. The odds ratio (OR) of walking speed of 0.4 m/s or slower was 2.87 (95% confidence interval [CI], 1.76-4.67) in those in the lowest third and 1.79 (95% CI, 1.14-2.81) in the middle third of grip strength vs those in the highest third. The risk of self-care disability was more than 2 times greater in the lowest vs the highest grip strength tertile. Adding chronic conditions identified at follow-up to the models predicting disability reduced the ORs related to grip strength only minimally.Conclusions: Among healthy 45- to 68-year-old men, hand grip strength was highly predictive of functional limitations and disability 25 years later. Good muscle strength in midlife may protect people from old age disability by providing a greater safety margin above the threshold of disability.
SN  - 0098-7484
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Md
U2  - PMID: 10022113.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Jian-Ming Zhang
AU  - Qin Wei
AU  - Ziaohang Zhao
AU  - Paterson, Bruce M.
T1  - Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/02/15/
VL  - 18
IS  - 4
M3  - Article
SP  - 926
EP  - 933
SN  - 02614189
AB  - Proliferating myoblasts express the muscle determination factor, MyoD, throughout the cell cycle in the absence of differentiation. Here we show that a mitogen-sensitive mechanism, involving the direct interaction between MyoD and cdk4, restricts myoblast differentiation to cells that have entered into the G0 phase of the cell cycle under mitogen withdrawal. Interaction between MyoD and cdk4 disrupts MyoD DNA-binding, muscle-specific gene activation and myogenic conversion of 10T1/2 cells independently of cyclin D1 and the CAK activation of cdk4. Forced induction of cyclin D1 in myotubes results in the cytoplasmic to nuclear translocation of cdk4. The specific MyoD­cdk4 interaction in dividing myoblasts, coupled with the cyclin D1-dependent nuclear targeting of cdk4, suggests a mitogen-sensitive mechanism whereby cyclin D1 can regulate MyoD function and the onset of myogenesis by controlling the cellular location of cdk4 rather than the phosphorylation status of MyoD. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL cycle
KW  - CYCLINS
KW  - MYOGENESIS
KW  - MYOBLASTS
KW  - MITOGENS
KW  - PHOSPHORYLATION
KW  - cdk4
KW  - cell cycle
KW  - cyclin d1
KW  - myogenesis
N1  - Accession Number: 13003874; Jian-Ming Zhang 1 Qin Wei Ziaohang Zhao Paterson, Bruce M.; Email Address: bruce@sunspot.nci.nih.gov; Affiliation:  1: Laboratory of Biochemistry, NCI, National Institutes of Health, Building 37 Room 4A21, 9000 Rockville Pike, Bethesda, MD, USA; Source Info: 2/15/99, Vol. 18 Issue 4, p926; Subject Term: CELL cycle; Subject Term: CYCLINS; Subject Term: MYOGENESIS; Subject Term: MYOBLASTS; Subject Term: MITOGENS; Subject Term: PHOSPHORYLATION; Author-Supplied Keyword: cdk4; Author-Supplied Keyword: cell cycle; Author-Supplied Keyword: cyclin d1; Author-Supplied Keyword: myogenesis; Number of Pages: 8p; Document Type: Article
L3  - 10.1093/emboj/18.4.926
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107186684
T1  - Which drug for treatment of hypertension?
AU  - Cutler J
Y1  - 1999/02/20/
N1  - Accession Number: 107186684. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - Hypertension -- Drug Therapy
KW  - Antihypertensive Agents
KW  - Clinical Trials
SP  - 604
EP  - 605
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 353 North American Edition
IS  - 9153
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - National Heart Lung and Blood Institute, Bethesda, MD 20892
U2  - PMID: 10030320.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Onodera, Masafumi
AU  - Nelson, David M.
AU  - Sakiyama, Yukio
AU  - Candotti, Fabio
AU  - Blaese, R. Michael
T1  - Gene Therapy for Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency: Improved Retroviral Vectors for Clinical Trials.
JO  - Acta Haematologica
JF  - Acta Haematologica
Y1  - 1999/03//
VL  - 101
IS  - 2
M3  - Article
SP  - 89
EP  - 96
SN  - 00015792
AB  - Severe combined immunodeficiency (SCID) caused by adenosine deaminase deficiency (ADA–) is the first genetic disorder to be treated with gene therapy. Since 1990 when the first trial started for 2 patients with ADA– SCID, five clinical trials enrolling 11 patients have been conducted with different clinical approaches and the results obtained from these trials have recently been reported. According to these reports, T cell-directed gene transfer was useful in the treatment of ADA– SCID whereas the retroviral-mediated gene transfer to hematopoietic stem cells was insufficient for achievement of clinical benefits. This chapter reviews several crucial problems inherent in the current retroviral technology based on the clinical data observed in these pioneering ADA gene therapy trials and presents our new retroviral vector system for the next stem cell gene therapy. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Acta Haematologica is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE therapy
KW  - RETROVIRUSES
KW  - STEM cells
KW  - T cells
KW  - IMMUNODEFICIENCY
KW  - Retroviral vector
KW  - Severe combined immunodeficiency, adenosine deaminase
KW  - Stem cells, hematopoietic
KW  - T lymphocytes, peripheral
N1  - Accession Number: 11333248; Onodera, Masafumi 1,2,3 Nelson, David M. 2 Sakiyama, Yukio 1 Candotti, Fabio 2 Blaese, R. Michael 2; Affiliation:  1: Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan  2: Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Md., USA  3: CREST, Japan Science and Technology Corporation (JST), Tsukuba, Jap; Source Info: 1999, Vol. 101 Issue 2, p89; Subject Term: GENE therapy; Subject Term: RETROVIRUSES; Subject Term: STEM cells; Subject Term: T cells; Subject Term: IMMUNODEFICIENCY; Author-Supplied Keyword: Retroviral vector; Author-Supplied Keyword: Severe combined immunodeficiency, adenosine deaminase; Author-Supplied Keyword: Stem cells, hematopoietic; Author-Supplied Keyword: T lymphocytes, peripheral; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3  - 10.1159/000040930
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Candotti, Fabio
AU  - Onodera, Masafumi
AU  - Knazek, Richard A.
AU  - Blaese, R. Michael
T1  - Retroviral-Mediated Transfer andExpression of the Common Gamma Chain intoHuman Hematopoietic Progenitors.
JO  - Acta Haematologica
JF  - Acta Haematologica
Y1  - 1999/03//
VL  - 101
IS  - 2
M3  - Article
SP  - 106
EP  - 110
SN  - 00015792
AB  - The common gamma chain (γ[sub c] ) of cytokine receptors is mutated in X-linked severe combined immunodeficiency, a lethal disorder characterized by the absence of both humoral and cellular immune defenses. Allogeneic bone marrow transplantation from HLA-identical siblings usually results in complete reconstitution of the immune system and is the current treatment of choice. Genetic correction and reinfusion of autologous hematopoietic stem cells represents an alternative therapeutic approach for those patients who lack suitable marrow donors. In this study, we show that retroviral-mediated transfer of the γ[sub c] gene results in efficient expression in CD34+ cells and high transduction rate of colony-forming progenitors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Acta Haematologica is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE therapy
KW  - HEMATOPOIETIC stem cells
KW  - RETROVIRUSES
KW  - GENETIC transformation
KW  - GENE expression
KW  - CYTOKINES
KW  - Hematopoietic progenitors
KW  - Retroviral vectors
KW  - XSCID
N1  - Accession Number: 11333246; Candotti, Fabio 1 Onodera, Masafumi 1 Knazek, Richard A. 1 Blaese, R. Michael 1; Affiliation:  1: Clinical Gene Therapy Branch, National Human Genome Research Institute, NIH, Bethesda, Md., USA; Source Info: 1999, Vol. 101 Issue 2, p106; Subject Term: GENE therapy; Subject Term: HEMATOPOIETIC stem cells; Subject Term: RETROVIRUSES; Subject Term: GENETIC transformation; Subject Term: GENE expression; Subject Term: CYTOKINES; Author-Supplied Keyword: Hematopoietic progenitors; Author-Supplied Keyword: Retroviral vectors; Author-Supplied Keyword: XSCID; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3  - 10.1159/000040932
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107127773
T1  - What is moderate drinking? Defining 'drinks' and drinking levels.
AU  - Dufour MC
Y1  - 1999/03//
N1  - Accession Number: 107127773. Language: English. Entry Date: 20000801. Revision Date: 20151016. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100900708. 
KW  - Alcohol Drinking -- Classification
KW  - Ethanol -- Blood
KW  - Ethanol -- Analysis
KW  - Patient Education
KW  - Drinking Behavior -- Education
KW  - Epidemiology -- Classification
KW  - Beverages -- Analysis
KW  - Research, Medical
KW  - United States
SP  - 5
EP  - 14
JO  - Alcohol Research & Health
JF  - Alcohol Research & Health
JA  - ALCOHOL RES HEALTH
VL  - 23
IS  - 1
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - Although the benefits and risks associated with moderate drinking have gained increasing attention in recent years from both researchers and the general public, no universal definition of moderate drinking exists. Most currently used definitions are based on a certain number of drinks consumed in a specific time period. Defining a 'drink,' however, also is difficult because alcoholic beverages can differ substantially in their alcohol content, even within the same beverage category (e.g., beer, wine, or distilled spirits). Because international differences in drink definitions also exist, comparing studies from different countries is difficult. The development of a universal definition of moderate drinking is hampered further by variations in the way alcohol consumption levels and drinking patterns are being assessed (i.e., the survey methods and assessment modes used). Despite these problems, definitions of moderate drinking and drinking guidelines have been developed in the United States and other countries.
SN  - 1535-7414
AD  - Deputy Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
U2  - PMID: 10890793.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107127773&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107201216
T1  - Report of a National Institutes of Health--Centers for Disease Control and Prevention workshop on the feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons.
AU  - Yanovski SZ
AU  - Bain RP
AU  - Williamson DF
Y1  - 1999/03//
N1  - Accession Number: 107201216. Language: English. Entry Date: 19990701. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Obesity
KW  - Seminars and Workshops
KW  - Centers for Disease Control and Prevention (U.S.)
KW  - National Institutes of Health (U.S.)
KW  - Weight Control
KW  - Research Ethics
KW  - Race Factors
KW  - Age Factors
KW  - Study Design
KW  - Needs Assessment
KW  - Comorbidity
KW  - Obesity -- Prevention and Control
KW  - Treatment Outcomes
SP  - 366
EP  - 372
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 69
IS  - 3
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - A workshop was convened in 1997 by the National Institutes of Health and the Centers for Disease Control and Prevention to consider the need for and feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons. Although the benefits of weight loss in obese individuals may seem obvious, little information is available showing that intentional weight loss improves long-term health outcomes. Observational studies may be unable to provide convincing answers about the magnitude and direction of the health effects of intentional weight loss. Workshop participants agreed that a well-designed randomized clinical trial could answer several questions necessary for developing a rational clinical and public health policy for treating obesity. Such information will ultimately provide needed guidance on the risks and benefits of weight loss to health care providers and payers, as well as to millions of obese Americans. Copyright (c) 1999 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
U2  - PMID: 10075318.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107201371
T1  - Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population.
AU  - Stolzenberg-Solomon RZ
AU  - Miller ER III
AU  - Maguire MG
AU  - Selhub J
AU  - Appel LJ
Y1  - 1999/03//
N1  - Accession Number: 107201371. Language: English. Entry Date: 19990701. Revision Date: 20150819. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Health Habits and History Questionnaire (HHHQ). Grant Information: Supported by an Intramural Research Training Award from the National Cancer Institute, a career development grant from the Heart, Lung, and Blood Institute (HL02635), a fellowship grant from the American Heart Association, and the Out-Patient General Clinical Research Center (RR00722) at the Johns Hopkins Medical Institutions. NLM UID: 0376027. 
KW  - Homocysteine -- Blood -- In Old Age
KW  - Dietary Proteins -- In Old Age
KW  - Coffee -- In Old Age
KW  - Diet -- In Old Age
KW  - Funding Source
KW  - Antioxidants
KW  - Blood Pressure Determination
KW  - Body Weights and Measures
KW  - Questionnaires
KW  - Blood Chemical Analysis
KW  - Health Behavior -- Evaluation
KW  - Nutritional Assessment
KW  - Body Mass Index
KW  - Smoking
KW  - Hormone Replacement Therapy
KW  - Vitamins
KW  - Pilot Studies
KW  - Nonexperimental Studies
KW  - Random Assignment
KW  - Double-Blind Studies
KW  - Data Analysis Software
KW  - Prospective Studies
KW  - Multiple Linear Regression
KW  - Pearson's Correlation Coefficient
KW  - Models, Statistical
KW  - Confidence Intervals
KW  - Descriptive Statistics
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 467
EP  - 475
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 69
IS  - 3
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - BACKGROUND: Elevated blood concentrations of total homocysteine (tHcy) have been implicated in the pathogenesis of atherosclerotic cardiovascular disease. Previous studies identified suboptimal nutritional status and dietary intake of folate, vitamin B-6, and vitamin B-12 as determinants of elevated tHcy. OBJECTIVE: We identified other nutritional factors associated with tHcy in 260 retired schoolteachers in the Baltimore metropolitan area. DESIGN: We performed observational analyses of baseline and 2-4-mo follow-up data collected in a study designed to test the feasibility of conducting a large-scale clinical trial of vitamin supplements by mail. The study population consisted of 151 women and 109 men with a median age of 64 y. At baseline, each participant completed a food-frequency questionnaire. At follow-up, fasting serum tHcy was measured. RESULTS: In multivariable linear regression and generalized linear models, there was an independent, inverse dose-response relation between dietary protein and In tHcy (P = 0.002) and a positive, significant dose-response relation between coffee consumption and In tHcy (P for trend = 0.01). Other significant predictors of In tHcy were creatinine (positive; P = 0.0001) and prestudy use of supplemental B vitamins (inverse; P = 0.03). In stratified analyses restricted to persons receiving standard multivitamin therapy, the association of 1n tHcy with dietary protein and coffee persisted. CONCLUSIONS: These results support the hypothesis that increased protein intake and decreased coffee consumption may reduce tHcy and potentially prevent atherosclerotic cardiovascular disease and other disease outcomes. Copyright (c) 1999 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Cancer Prevention Studies Branch, National Cancer Institute, 6006 Executive Boulevard, Suite 321, Bethesda, MD 20892-7058. E-mail: RS221Z@NIH.GOV
U2  - PMID: 10075332.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Corti, Maria-Chiara
AU  - Guralnik, Jack M.
AU  - Ferrucci, Luigi
AU  - Izmirlian, Grant
AU  - Leveille, Suzanne G.
AU  - Pahor, Marco
AU  - Cohen, Harvey J.
AU  - Pieper, Carl
AU  - Havlik, Richard J.
T1  - Evidence for a Black--White Crossover in All-Cause and Coronary Heart Disease Mortality in an Older Population: The North Carolina EPESE.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/03//
VL  - 89
IS  - 3
M3  - Article
SP  - 308
EP  - 314
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. Methods. A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina were interviewed in 1986 and followed up for mortality until 1994. Hazard ratios (HRs) for all-cause and cause-specific mortality were calculated, with adjustment for sociodemographic and coronary heart disease (CHD) risk factors. Results. Black persons had higher mortality rates than Whites at young-old age (65-80 years) but had significantly lower mortality rates after age 80. Black persons age 80 or older had a significantly lower risk of all-cause mortality (HR of Blacks vs Whites, 0.75; 95% confidence interval [CI] = 0.62, 0.90) and of CHD mortality (HR 0.44; 95% CI = 0.30, 0.66). These differences were not observed for other causes of death. Conclusions. Racial differences in mortality are modified by age. This mortality crossover could be attributed to selective survival of the healthiest oldest Blacks or to other biomedical factors affecting longevity after age 80. Because the crossover was observed for CHD deaths only, age overreporting by Black older persons seems an unlikely explanation of the mortality differences. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RACIAL differences
KW  - MORTALITY
KW  - SOCIODEMOGRAPHIC factors
KW  - OLD age
KW  - CORONARY heart disease
KW  - NORTH Carolina
N1  - Accession Number: 1606365; Corti, Maria-Chiara 1,2 Guralnik, Jack M. 1; Email Address: guralnij@gw.nia.nih.gov Ferrucci, Luigi 3 Izmirlian, Grant 1 Leveille, Suzanne G. 1 Pahor, Marco 4 Cohen, Harvey J. 5 Pieper, Carl 5 Havlik, Richard J. 1; Affiliation:  1: Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Md.  2: Geriatric Department, Ospedale di Camposampiero, Padova, Italy  3: Geriatric Department, Ospedale "I Fraticini," Florence, Italy  4: Department of Preventive Medicine, University of Tennessee, Memphis  5: Duke University Center for Study of Aging and Human Development, Durham, N.C.; Source Info: Mar1999, Vol. 89 Issue 3, p308; Subject Term: RACIAL differences; Subject Term: MORTALITY; Subject Term: SOCIODEMOGRAPHIC factors; Subject Term: OLD age; Subject Term: CORONARY heart disease; Subject Term: NORTH Carolina; Number of Pages: 7p; Illustrations: 5 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sahyoun, Nadine R.
AU  - Hochberg, Marc C.
AU  - Helinick, Charles G.
AU  - Harris, Tamara
AU  - Pamuk, Elsie R.
T1  - Body Mass Index, Weight Change, and Incidence of Self-Reported Physician-Diagnosed Arthritis Among Women.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/03//
VL  - 89
IS  - 3
M3  - Article
SP  - 391
EP  - 394
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined the relationship between body mass index (BMI), weight change, and arthritis in women. Methods. Data were taken from the 1982-1984 National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study of 3617 women, aged 25 to 74 years. Results. Women with a BMI greater than 32 at initial interview were at significantly higher risk of developing arthritis than women with a BMI of 19 to 21.9. Compared with stable-weight women with a BMI of less than 25, women who were obese at initial interview (BMI > 29) and who subsequently maintained their weight or gained more than 10% of their body weight were at significantly higher risk of developing arthritis. conclusions. Attaining and maintaining a healthy weight may reduce the risk of developing arthritis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BODY mass index
KW  - ARTHRITIS
KW  - HEALTH & Nutrition Examination Survey
KW  - BODY weight
KW  - OVERWEIGHT persons
KW  - WOMEN -- Diseases
N1  - Accession Number: 1606380; Sahyoun, Nadine R. 1; Email Address: ncs8@cdc.gov Hochberg, Marc C. 2 Helinick, Charles G. 3 Harris, Tamara 4 Pamuk, Elsie R. 1; Affiliation:  1: Office of Analysis, Epidemiology, and Health Promotion, National Center for Health Statistics, Hyattsville, Md.  2: University of Maryland School of Medicine, Baltimore  3: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga.  4: National Institute on Aging, Bethesda, Md.; Source Info: Mar1999, Vol. 89 Issue 3, p391; Subject Term: BODY mass index; Subject Term: ARTHRITIS; Subject Term: HEALTH & Nutrition Examination Survey; Subject Term: BODY weight; Subject Term: OVERWEIGHT persons; Subject Term: WOMEN -- Diseases; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107206511
T1  - Evidence for a Black-White crossover in all-cause and coronary heart disease mortality in an older population: the North Carolina EPESE.
AU  - Corti M
AU  - Guralnik JM
AU  - Ferrucci L
AU  - Izmirlian G
AU  - Leveille SG
AU  - Pahor M
AU  - Cohen HJ
AU  - Pieper C
AU  - Havlik RJ
Y1  - 1999/03//
N1  - Accession Number: 107206511. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Supported in part by the Project MinSan RF RUGs/97/2-INRCA; by contracts N01-AG-4-2110 and N01-AG1-2102 with the National Institute on Aging, National Institutes of Health. NLM UID: 1254074. 
KW  - Coronary Disease -- Ethnology -- In Old Age
KW  - Coronary Disease -- Mortality -- In Old Age
KW  - Aging
KW  - Funding Source
KW  - Epidemiological Research
KW  - Prospective Studies
KW  - Cox Proportional Hazards Model
KW  - Mortality
KW  - Probability Sample
KW  - Surveys
KW  - Interviews
KW  - Body Mass Index
KW  - Blood Pressure Determination
KW  - Death Certificates
KW  - Race Factors
KW  - Blacks
KW  - Whites
KW  - North Carolina
KW  - Socioeconomic Factors
KW  - Age Factors
KW  - Prevalence
KW  - Data Analysis Software
KW  - Relative Risk
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 308
EP  - 314
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 89
IS  - 3
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. METHODS: A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina were interviewed in 1986 and followed up for mortality until 1994. Hazard ratios (HRs) for all-cause and cause-specific mortality were calculated, with adjustment for sociodemographic and coronary heart disease (CHD) risk factors. RESULTS: Black persons had higher mortality rates than Whites at young-old age (65-80 years) but had significantly lower mortality rates after age 80. Black persons age 80 or older had a significantly lower risk of all-cause mortality (HR of Blacks vs Whites, 0.75; 95% confidence interval [CI] = 0.62, 0.90) and of CHD mortality (HR 0.44: 95% CI = 0.30, 0.66). These differences were not observed for other causes of death. CONCLUSIONS: Racial differences in mortality are modified by age. This mortality crossover could be attributed to selective survival of the healthiest oldest Blacks or to other biomedical factors affecting longevity after age 80. Because the crossover was observed for CHD deaths only, age overreporting by Black older persons seems an unlikely explanation of the mortality differences.
SN  - 0090-0036
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD
U2  - PMID: 10076478.
DO  - 10.2105/AJPH.89.3.308
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Simopoulos, Artemis P.
AU  - Leaf, Alexander
AU  - Salem, Jr., Norman
T1  - Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids.
JO  - Annals of Nutrition & Metabolism
JF  - Annals of Nutrition & Metabolism
Y1  - 1999/03//
VL  - 43
IS  - 2
M3  - Article
SP  - 127
EP  - 130
SN  - 02506807
AB  - Presents information on the Workshop on the Essentiality of and Recommended Dietary Intakes  for Omega-6 and Omega-3 Fatty Acids held at The Cloisters, National Institutes of Health in Bethesda, Maryland from April 7-9, 1999.  Workshop sponsors; Presentations and discussions; Recommendations.
KW  - MEETINGS
KW  - CONFERENCES & conventions
KW  - BETHESDA (Md.)
KW  - MARYLAND
KW  - UNITED States
N1  - Accession Number: 11333790; Simopoulos, Artemis P. 1 Leaf, Alexander 2 Salem, Jr., Norman 3; Affiliation:  1: The Center for Genetics, Nutrition and Health, Washington, D.C.  2: Massachusetts General Hospital, Charlestown, Mass.  3: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Md., USA; Source Info: 1999, Vol. 43 Issue 2, p127; Subject Term: MEETINGS; Subject Term: CONFERENCES & conventions; Subject Term: BETHESDA (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 4p; Document Type: Article
L3  - 10.1159/000012777
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - GU, MINGGAO
AU  - FOLLMANN, DEAN
AU  - GELLER, NANCY L.
T1  - Monitoring a general class of two-sample survival statistics with applications.
JO  - Biometrika
JF  - Biometrika
Y1  - 1999/03//
VL  - 86
IS  - 1
M3  - Article
SP  - 45
EP  - 57
SN  - 00063444
AB  - This paper considers a general class of statistics for testing the equality of two survival distributions in clinical trials with sequential monitoring. The tests can be expressed as Lebesgue-Stieltjes integrals of a weight function with respect to the difference between two survival distributions. Prominent members of this class include the two-sample difference in Kaplan-Meier estimates, the test of medians (Brookmeyer & Crowley, 1982), a truncated version of Efron's (1967) test and the Pepe-Fleming statistic (Pepe & Fleming, 1989, 1991). Statistics in this class are shown to converge to a Gaussian process, indexed by information time, under both null and local alternatives even if different statistics are used at different information times. Properly standardised, statistics in a subclass converge to Gaussian processes with independent increments so that the usual group sequential techniques for monitoring a clinical trial can be applied. The design of a trial comparing two treatments with respect to mother-to-newborn transmission of HIV is used to illustrate practical aspects of monitoring. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CLINICAL trials
KW  - VERTICAL transmission (Communicable diseases)
KW  - FAILURE time data analysis
KW  - STIELTJES integrals
KW  - LEBESGUE integral
KW  - MATERNAL-fetal exchange
KW  - Clinical trial
KW  - Failure time data
KW  - Group sequential monitoring
KW  - Pepe-Fleming statistic
KW  - Pepe-Fleming statistic.
N1  - Accession Number: 44611585; GU, MINGGAO 1; Email Address: minggao@cuhk.edu.hk FOLLMANN, DEAN 2; Email Address: follmann@helix.nih.gov GELLER, NANCY L. 2; Email Address: ng@helix.nih.gov; Affiliation:  1: Department of Statistics, The Chinese University of Hong Kong, New Territory, Hong Kong, P.R.C.  2: Office of Biostatistics Research, National Heart Lung and Blood Institute, 2 Rockledge Center, Bethesda, Maryland 20892-7938, U.S.A.; Source Info: Mar1999, Vol. 86 Issue 1, p45; Subject Term: CLINICAL trials; Subject Term: VERTICAL transmission (Communicable diseases); Subject Term: FAILURE time data analysis; Subject Term: STIELTJES integrals; Subject Term: LEBESGUE integral; Subject Term: MATERNAL-fetal exchange; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Failure time data; Author-Supplied Keyword: Group sequential monitoring; Author-Supplied Keyword: Pepe-Fleming statistic; Author-Supplied Keyword: Pepe-Fleming statistic.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Stanyon, R.
AU  - Yang, F.
AU  - Cavagna, P.
AU  - O'brien, P. C. M.
AU  - Bagga, M.
AU  - Ferguson-smith, M. A.
AU  - Wienberg, J.
T1  - Reciprocal chromosome painting shows that genomic rearrangement between rat and mouse proceeds ten times faster than between humans and cats.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1999/03//
VL  - 84
IS  - 3/4
M3  - Article
SP  - 150
EP  - 155
SN  - 03010171
AB  - Reciprocal chromosome painting between mouse and rat using complete chromosome probe sets of both species permitted us to assign the chromosomal homology between these rodents. The comparative gene mapping data and chromosome painting have a better than 90% correspondence. The reciprocal painting results graphically show that mouse and rat have strikingly different karyotypes. At least 14 translocations have occurred in the 10–20 million years of evolution that separates these two species. The evolutionary rate of chromosome translocations between these two rodents appears to be up to 10 times greater than that found between humans and cats, or between humans and chimpanzees, where over the last 5–6 million years just one translocation has occurred. Outgroup comparison shows that the mouse genome has incorporated at least three times the amount of interchromosomal rearrangements compared to the rat genome. The utility of chromosome painting was also illustrated by the assignment of two new chromosome homologies between rat and mouse unsuspected by gene mapping: between mouse 11 and rat 20 and between mouse 17 and rat 6. We conclude that reciprocal chromosome painting is a powerful method, which can be used with confidence to chart the genome and predict the chromosome location of genes. Reciprocal painting combined with gene mapping data will allow the construction of large-scale comparative chromosome maps between placental mammals and perhaps other animals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cytogenetics & Cell Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE mapping
KW  - HOMOLOGY (Biology)
KW  - CHROMOSOME banding
KW  - FLUORESCENCE in situ hybridization
KW  - KARYOTYPES
KW  - MAMMALS
KW  - GENOMICS
N1  - Accession Number: 12184463; Stanyon, R. 1 Yang, F. 2 Cavagna, P. 3 O'brien, P. C. M. 2 Bagga, M. 2 Ferguson-smith, M. A. 2 Wienberg, J. 1; Email Address: wienbergj@mail.ncifcrf.gov; Affiliation:  1: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD (USA)  2: Department of Pathology, Cambridge University, Cambridge (UK)  3: Institute of Comparative Anatomy, University of Genoa, Genoa (Italy); Source Info: Mar1999, Vol. 84 Issue 3/4, p150; Subject Term: GENE mapping; Subject Term: HOMOLOGY (Biology); Subject Term: CHROMOSOME banding; Subject Term: FLUORESCENCE in situ hybridization; Subject Term: KARYOTYPES; Subject Term: MAMMALS; Subject Term: GENOMICS; Number of Pages: 6p; Document Type: Article
L3  - 10.1159/000015244
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107184351
T1  - Racial and ethnic differences in glycemic control of adults with type 2 diabetes.
AU  - Harris MI
AU  - Eastman RC
AU  - Cowie CC
AU  - Flegal KM
AU  - Eberhardt MS
Y1  - 1999/03//
N1  - Accession Number: 107184351. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975. 
KW  - Diabetes Mellitus, Type 2
KW  - Glycemic Control
KW  - Race Factors
KW  - Secondary Analysis
KW  - Blacks
KW  - Hispanics
KW  - Descriptive Statistics
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Multiple Logistic Regression
KW  - Odds Ratio
KW  - P-Value
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 403
EP  - 408
JO  - Diabetes Care
JF  - Diabetes Care
JA  - DIABETES CARE
VL  - 22
IS  - 3
CY  - Alexandria, Virginia
PB  - American Diabetes Association
AB  - OBJECTIVE: To evaluate glycemic control in a representative sample of U.S. adults with type 2 diabetes. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican Americans aged > or = 20 years. Information on medical history and treatment of diabetes was obtained to determine those who had been diagnosed with type 2 diabetes by a physician before the survey (n = 1,480). Fasting plasma glucose and HbA1c were measured, and the frequencies of sociodemographic and clinical variables related to glycemic control were determined. RESULTS: A higher proportion of non-Hispanic blacks were treated with insulin and a higher proportion of Mexican Americans were treated with oral agents compared with non-Hispanic whites, but the majority of adults in each racial or ethnic group (71-83%) used pharmacologic treatment for diabetes. Use of multiple daily insulin injections was more common in whites. Blood glucose self-monitoring was less common in Mexican Americans, but most patients had never self-monitored. HbA1c values in the nondiabetic range were found in 26% of non-Hispanic whites, 17% of non-Hispanic blacks, and 20% of Mexican Americans. Poor glycemic control (HbA1c > 8%) was more common in non-Hispanic black women (50%) and Mexican-American men (45%) compared with the other groups (35-38%), but HbA1c for both sexes and for all racial and ethnic groups was substantially higher than normal levels. Those with HbA1c > 8% included 52% of insulin-treated patients and 42% of those taking oral agents. There was no relationship of glycemic control to socioeconomic status or access to medical care in any racial or ethnic group. CONCLUSIONS: These data indicate that many patients with type 2 diabetes in the U.S. have poor glycemic control, placing them at high risk of diabetic complications. Non-Hispanic black women, Mexican-American men, and patients treated with insulin and oral agents were disproportionately represented among those in poor glycemic control. Clinical, public health, and research efforts should focus on more effective methods to control blood glucose in patients with diabetes.
SN  - 0149-5992
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, Building 45, Room 5AN24, Bethesda, MD 20892. E-mail: harrism@ep.niddk.nih.gov
U2  - PMID: 10097918.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Xiao Yang
AU  - Letterio, John J.
AU  - Lechleider, Robert J.
AU  - Lin Chen
AU  - Huyman, Russ
AU  - Hua Gu
AU  - Roberts, Anita B.
AU  - Chuxia Deng
T1  - Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-ß.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/03//3/1/99
VL  - 18
IS  - 5
M3  - Article
SP  - 1280
EP  - 1291
SN  - 02614189
AB  - SMAD3 is one of the intracellular mediators that transduces signals from transforming growth factor-β (TGF-β) and activin receptors. We show that SMAD3 mutant mice generated by gene targeting die between 1 and 8 months due to a primary defect in immune function. Symptomatic mice exhibit thymic involution, enlarged lymph nodes, and formation of bacterial abscesses adjacent to mucosal surfaces. Mutant T cells exhibit an activated phenotype in vivo, and are not inhibited by TGF-β1 in vitro. Mutant neutrophils are also impaired in their chemotactic response toward TGF-β. Chronic intestinal inflammation is infrequently associated with colonic adenocarcinoma in mice older than 6 months of age. These data suggest that SMAD3 has an important role in TGF-β-mediated regulation of T cell activation and mucosal immunity, and that the loss of these functions is responsible for chronic infection and the lethality of Smad3-null mice. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE targeting
KW  - GENETIC engineering
KW  - IMMUNE response
KW  - T cells
KW  - TRANSFORMING growth factors-beta
KW  - INFLAMMATION
KW  - MOLECULAR biology
KW  - bacterial infections
KW  - gene targeting
KW  - inflammation
KW  - signaling
KW  - smad3
KW  - tgf-&beta
N1  - Accession Number: 13003903; Xiao Yang 1,2 Letterio, John J. 3 Lechleider, Robert J. 3 Lin Chen 1 Huyman, Russ 4 Hua Gu 4 Roberts, Anita B. 3 Chuxia Deng 1; Email Address: chuxiad@bdg10.niddk.nih.gov; Affiliation:  1: Genetics of Development and Disease Branch, 10/9N105, NIDDK, Bethesda, MD 20892, USA  2: Institute of Biotechnology, 20 Dongdajie Street, Beijing 100071, China  3: Laboratory of Cell Regulation and Carcinogenesism NCI, Bethesda, MD 20892, USA  4: Laboratory of Immunology, NIAID, National Institutes of Health Bethesda, MD 20892, USA; Source Info: 3/1/99, Vol. 18 Issue 5, p1280; Subject Term: GENE targeting; Subject Term: GENETIC engineering; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: TRANSFORMING growth factors-beta; Subject Term: INFLAMMATION; Subject Term: MOLECULAR biology; Author-Supplied Keyword: bacterial infections; Author-Supplied Keyword: gene targeting; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: signaling; Author-Supplied Keyword: smad3; Author-Supplied Keyword: tgf-&beta; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/18.5.1280
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Shao, Rong-Guang
AU  - Cao, Chun-Xia
AU  - Zhang, Hongliang
AU  - Kohn, Kurt W.
AU  - Wold, Marc S.
AU  - Pommier, Yves
T1  - Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/03//3/1/99
VL  - 18
IS  - 5
M3  - Article
SP  - 1397
EP  - 1406
SN  - 02614189
AB  - Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and repair. In human cells treated with the topoisomerase inhibitors camptothecin or etoposide (VP-16), we find that RPA2, the middle-sized subunit of RPA, becomes rapidly phosphorylated. This response appears to be due to DNA-dependent protein kinase (DNA-PK) and to be independent of p53 or the ataxia telangiectasia mutated (ATM) protein. RPA2 phosphorylation in response to camptothecin required ongoing DNA replication. Camptothecin itself partially inhibited DNA synthesis, and this inhibition followed the same kinetics as DNA-PK activation and RPA2 phosphorylation. DNA-PK activation and RPA2 phosphorylation were prevented by the cell-cycle checkpoint abrogator 7-hydroxystaurosporine (UCN-01), which markedly potentiates camptothecin cytotoxicity. The DNA-PK catalytic subunit (DNA-PKcs) was found to bind RPA which was replaced by the Ku autoantigen upon camptothecin treatment. DNA-PKcs interacted directly with RPA1 in vitro. We propose that the encounter of a replication fork with a topoisomerase­DNA cleavage complex could lead to a juxtaposition of replication fork-associated RPA and DNA double-strand end-associated DNA-PK, leading to RPA2 phosphorylation which may signal the presence of DNA damage to an S-phase checkpoint mechanism. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEINS
KW  - DNA replication
KW  - DNA synthesis
KW  - CAMPTOTHECIN
KW  - DNA topoisomerases
KW  - DNA damage
KW  - camptothecin
KW  - dna damage
KW  - dna-dependent protein kinase
KW  - rpa2 phosphorylation
N1  - Accession Number: 13003892; Shao, Rong-Guang 1 Cao, Chun-Xia 1 Zhang, Hongliang 1 Kohn, Kurt W. 1 Wold, Marc S. 2 Pommier, Yves 1; Email Address: pommier@nih.gov; Affiliation:  1: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255  2: Department of Biochemistry, University of Iowa, Iowa City, IA 52242-1109, USA; Source Info: 3/1/99, Vol. 18 Issue 5, p1397; Subject Term: PROTEINS; Subject Term: DNA replication; Subject Term: DNA synthesis; Subject Term: CAMPTOTHECIN; Subject Term: DNA topoisomerases; Subject Term: DNA damage; Author-Supplied Keyword: camptothecin; Author-Supplied Keyword: dna damage; Author-Supplied Keyword: dna-dependent protein kinase; Author-Supplied Keyword: rpa2 phosphorylation; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/18.5.1397
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107204512
T1  - Poliovirus immunizations: what goes around, comes around.
AU  - Soto NE
AU  - Lutwick LI
Y1  - 1999/03//1999 Mar
N1  - Accession Number: 107204512. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Poliomyelitis -- Prevention and Control
KW  - Poliovirus Vaccine -- Administration and Dosage
KW  - Immunization Schedule
KW  - Adult
KW  - Child
KW  - Poliovirus Vaccine -- Immunology
SP  - 265
EP  - 278
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 13
IS  - 1
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Although poliovirus vaccination is nto new, the recent changes in ACIP recommendations involving polio vaccinations are. Currently, wild type poliovirus has been eliminated in the Western hemisphere, but vaccine-associated cases (VAPP) still occur. The new recommendations are intended to continue providing protection and to eliminate VAPP cases from occurring in vaccinees or close contacts. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0891-5520
AD  - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland
U2  - PMID: 10198803.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Spencer, Richard
T1  - Guest editorial: Advanced signal processing in MRI. Part I.
JO  - International Journal of Imaging Systems & Technology
JF  - International Journal of Imaging Systems & Technology
Y1  - 1999/03//
VL  - 10
IS  - 2
M3  - Article
SP  - 107
EP  - 108
SN  - 08999457
AB  - Focuses on the importance of magnetic resonance imaging (MRI) as a type of diagnostic procedure in medicine. Focus of MRI on estimation of tissue parameters; Significance of MRI experiments towards the improvement of diagnostic procedures; Advantages of MRI over other diagnostic applications.
KW  - MAGNETIC resonance imaging
KW  - DIAGNOSTIC imaging
KW  - IMAGING systems in medicine
KW  - NONINVASIVE diagnostic tests
KW  - MEDICAL equipment
N1  - Accession Number: 13509916; Spencer, Richard 1; Affiliation:  1: Nuclear Magnetic Resonance Unit National Institute on Aging Baltimore, MA 21224; Source Info: Mar1999, Vol. 10 Issue 2, p107; Subject Term: MAGNETIC resonance imaging; Subject Term: DIAGNOSTIC imaging; Subject Term: IMAGING systems in medicine; Subject Term: NONINVASIVE diagnostic tests; Subject Term: MEDICAL equipment; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Richard D. Irwin
AU  - John E. French
AU  - Michael Elwell
AU  - Joe Haseman
AU  - A. G. Braun
AU  - F. A. Voelker
T1  - Carcinogenicity of dermally administered 1,2-Dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice.
JO  - Journal of Applied Toxicology
JF  - Journal of Applied Toxicology
Y1  - 1999/03//Mar/Apr1999
VL  - 19
IS  - 2
M3  - Article
SP  - 123
EP  - 132
SN  - 0260437X
AB  - 1,2-Dihydro-2,2,4-trimethylquinoline (TMQ) was evaluated in a 2-year study in which groups of 60 male or female F344 rats received 0, 36 or 60 mg kg-1 (0, 0.022, or 0.037 mg cm-2) and groups of 60 male or female B6C3F1 mice received 0, 3.6 or 10 mg kg-1 (0, 0.00136, 0.00435 mg cm-2) in acetone by topical administration. Survival of all treated groups was comparable to survival of controls. Mean body weights of female rats were lower than those of controls throughout the study but mean body weights of male rats and male and female mice were comparable to the mean body weights of controls. No neoplasms of the skin were observed in any group of rats or mice. Acanthosis at the site of application was increased in male and female rats that received 60 or 100 mg kg-1 and hyperkeratosis was increased in female rats that received 60 mg kg-1. The incidences of renal tubule adenoma and renal tubule adenoma or carcinoma were increased significantly in the 60 and 100 mg kg-1 groups of male rats. There were no neoplastic or non-neoplastic lesions in mice associated with exposure to 1,2-dihydro-2,2,4-trimethylquinoline. In a 1-year initiation&#150;promotion study, groups of 30 female SENCAR mice received an initiating dose of 50 mg kg-1 1,2-dihydro-2,2,4-trimethylquinoline followed by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA), or an initiating dose of 7,12-dimethylbenzanthracene (DMBA) followed by promotion with 5, 10 or 25 mg kg-1 1,2-dihydro-2,2,4-trimethylquinoline. Other groups served as initiator control, promoter control, vehicle control and positive control (DMBA initiation, TPA promotion). In this system, 1,2-dihydro-2,2,4-trimethylquinoline-initiated skin was not promoted by TPA, and DMBA-initiated skin was not promoted by 1,2-dihydro-2,2,4-trimethylquinoline. Copyright &copy; 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Applied Toxicology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Weight gain
KW  - Body size
KW  - Kidney tubules
KW  - Keratosis
N1  - Accession Number: 18468106; Richard D. Irwin 1; John E. French 1; Michael Elwell 1; Joe Haseman 1; A. G. Braun 2; F. A. Voelker 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; 2: al Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, <SUP>A1</SUP>, TSI Mason Laboratories, Worcester, MA, USA; Issue Info: Mar/Apr1999, Vol. 19 Issue 2, p123; Subject Term: Weight gain; Subject Term: Body size; Subject Term: Kidney tubules; Subject Term: Keratosis; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Jin, Dong-Yan
AU  - Jeang, Kuan-Teh
T1  - Isolation of Full-Length cDNA and Chromosomal Localization of Human NF-κB Modulator NEMO to Xq28.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1999/03//
VL  - 6
IS  - 2
M3  - Article
SP  - 115
EP  - 120
PB  - BioMed Central
SN  - 10217770
AB  - NEMO is an essential component of the IκB kinase complex. Others have shown that expression of mouse NEMO can complement the lack of responsiveness to NF-κB stimuli in two NEMO-deficient cell lines. Here we report the isolation of a full-length human NEMO cDNA. Virtual translation of human NEMO cDNA predicts a 48-kD coiled-coil protein which shares 87.9% identity and 90.5% similarity with the mouse homolog. By sequence alignment, we mapped the human NEMO gene to chromosome Xq28. We note that the NEMO and the G6PD (glucose-6-phosphate dehydrogenase) loci are arranged in a head-to-head orientation separated by no more than 800 bp. This map location is further supported by the sequence of an alternatively spliced variant of human NEMO mRNA. Thus, human NEMO is an X-linked gene closely adjacent to the G6PD locus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HUMAN chromosomes
KW  - HUMAN genetics
KW  - CHROMOSOMES
KW  - NF-kappa B (DNA-binding protein)
KW  - TRANSCRIPTION factors
KW  - DNA-binding proteins
KW  - HTLV-1 Tax
KW  - Human chromosome Xq28
KW  - IκB
KW  - IκB kinase
KW  - NEMO
KW  - NF-κB
N1  - Accession Number: 11372072; Jin, Dong-Yan 1 Jeang, Kuan-Teh 1; Affiliation:  1: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md., USA; Source Info: 1999, Vol. 6 Issue 2, p115; Subject Term: HUMAN chromosomes; Subject Term: HUMAN genetics; Subject Term: CHROMOSOMES; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: TRANSCRIPTION factors; Subject Term: DNA-binding proteins; Author-Supplied Keyword: HTLV-1 Tax; Author-Supplied Keyword: Human chromosome Xq28; Author-Supplied Keyword: IκB; Author-Supplied Keyword: IκB kinase; Author-Supplied Keyword: NEMO; Author-Supplied Keyword: NF-κB; Number of Pages: 6p; Document Type: Article
L3  - 10.1159/000025378
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107054824
T1  - Recruiting minority cancer patients into cancer clinical trials: a pilot project involving the Eastern Cooperative Oncology Group and the National Medical Association.
AU  - McCaskill-Stevens W
AU  - Pinto H
AU  - Marcus AC
AU  - Comis R
AU  - Morgan R
AU  - Plomer K
AU  - Schoentgen S
AU  - McCaskill-Stevens, W
AU  - Pinto, H
AU  - Marcus, A C
AU  - Comis, R
AU  - Morgan, R
AU  - Plomer, K
AU  - Schoentgen, S
Y1  - 1999/03//3/1/1999
N1  - Accession Number: 107054824. Language: English. Entry Date: 20010928. Revision Date: 20161120. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Clinical Trials -- Methods
KW  - Research Subject Recruitment
KW  - Minority Groups
KW  - Communication Barriers
KW  - Neoplasms -- Therapy
KW  - Physician's Role
KW  - Pilot Studies
KW  - Comparative Studies
KW  - Questionnaires
KW  - United States
KW  - Human
SP  - 1029
EP  - 1039
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 3
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: Minority accrual onto clinical trials is of significant interest to cooperative oncology study groups. The Eastern Cooperative Oncology Group (ECOG) conducted a study to identify barriers and solutions to African American accrual onto clinical trials.Methods: We hypothesize that the National Medical Association (NMA) might provide insight into ways to increase minority participation and that ECOG might facilitate that participation. Four sites were selected in which NMA chapters existed and ECOG main institutions with less than half of the corresponding percentage of minorities in their communities entered trials for 1992. Fifteen workshops were conducted using discussions and open-ended, self-administered questionnaires.Results: Seventy percent of NMA physicians cited mistrust of the research centers, fear of losing patients, and a lack of respect from ECOG institutions as the most important barriers to minority cancer patient referrals, compared with 30% for ECOG physicians. Sixty-nine percent of NMA and 43% of ECOG physicians cited a lack of information about specific trials. Nearly half of NMA physicians (47%) cited a lack of minority investigators as a barrier, compared with 4% of ECOG physicians. Solutions by both groups were improved communication (73%) and culturally relevant educational materials (40%). ECOG physicians cited more minority outreach staff as a potential solution (22% v 6%). NMA physicians cited increased involvement of referring physicians (44% v4%).Conclusion: NMA physicians who serve a significant sector of the African American population demonstrated a willingness to participate and work with a cooperative group effort to increase participation of minority patients and investigators.
SN  - 0732-183X
AD  - Division of Cancer Prevention, National Cancer Institute/National Institutes of Health, Rockville, MD 20852, USA
AD  - Division of Cancer Prevention, National Cancer Institute/National Institutes of Health, 6130 Executive Blvd, Room 300, Rockville, MD 20852; wm57h@nih.gov
U2  - PMID: 10071298.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Rosenberg, S. A.;
AU  - Yang, J. C.;
AU  - Schwartzentruber, D. J.;
AU  - Hwu, P.;
AU  - Steinberg, S. M.;
AU  - \ET/;
T1  - Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b
CT  - Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b
JO  - Journal of Clinical Oncology (USA)
JF  - Journal of Clinical Oncology (USA)
Y1  - 1999/03/01/
VL  - 17
IS  - Mar
SP  - 968
EP  - 975
SN  - 0732183X
AD  - Surg. Branch, Div. of Clin. Sci., Natl. Cancer Inst., 9000 Rockville Pike, Bldg. 10, Rm. 2B42, Bethesda, MD 20892, USA Internet: steven
N1  - Accession Number: 37-07294; Language: English; Chemical Name: Tamoxifen--10540-29-1 Tamoxifen--10540-29-1 Dacarbazine--4342-03-4 Dacarbazine--4342-03-4 Cisplatin--15663-27-1 Cisplatin--15663-27-1 Interleukin 2--102524-44-7 Interleukin 2--102524-44-7 Interferon alfa-2b--99210-65-8 Interferon alfa-2b--99210-65-8; References: 22; Journal Coden: JCONDN; Human Indicator: Yes; Section Heading: Drug Evaluations; Toxicity; Abstract Author: Elizabeth G. Rudnic
N2  - To compare chemotherapy with chemoimmunotherapy in patients with metastatic melanoma, 102 patients, ages 11-70 yr, received chemotherapy composed of tamoxifen, cisplatin, and dacarbazine alone or followed by 4 days of 6 MU/sq m of subcutaneous interferon alfa-2b and 720,000 IU/kg of intravenous interleukin-2 every 8 h beginning on days 5 and 26; response, survival, and toxicity were observed. In patients receiving only chemotherapy, 14 objective responses (27%) were observed. In those receiving chemoimmunotherapy, 22 objective responses (44%) were observed. However, there was a trend toward a survival advantage for patients receiving chemotherapy alone vs those receiving chemoimmunotherapy as well (median survival of 15.8 months compared with 10.7 months, respectively).
KW  - Tamoxifen--melanoma-;
KW  - Dacarbazine--melanoma-;
KW  - Cisplatin--melanoma-;
KW  - Interleukin 2--melanoma-;
KW  - Interferon alfa-2b--melanoma-;
KW  - Combined therapy--cisplatin, dacarbazine and tamoxifen--melanoma, alone and with immunotherapy;
KW  - Combined therapy--dacarbazine, cisplatin and tamoxifen--melanoma, alone and with immunotherapy;
KW  - Combined therapy--tamoxifen, cisplatin and dacarbazine--melanoma, alone and with immunotherapy;
KW  - Combined therapy--interleukin 2, interferon alfa-2b and antineoplastic agents--melanoma;
KW  - Combined therapy--interferon alfa-2b, interleukin 2 and antineoplastic agents--melanoma;
KW  - Combined therapy--antineoplastic agents, interferon alfa-2b and interleukin 2--melanoma;
KW  - Melanoma--cisplatin--combined therapy;
KW  - Melanoma--dacarbazine--combined therapy;
KW  - Melanoma--tamoxifen--combined therapy;
KW  - Melanoma--interferon alfa-2b--combined therapy;
KW  - Melanoma--interleukin 2--combined therapy;
KW  - Toxicity--cisplatin--combined therapy;
KW  - Toxicity--dacarbazine--combined therapy;
KW  - Toxicity--tamoxifen--combined therapy;
KW  - Toxicity--interferon alfa-2b--combined therapy;
KW  - Toxicity--interleukin 2--combined therapy;
KW  - Antineoplastic agents--cisplatin--combined therapy;
KW  - Antineoplastic agents--dacarbazine--combined therapy;
KW  - Antineoplastic agents--tamoxifen--combined therapy;
KW  - Immunostimulant agents--interferon alfa-2b--combined therapy;
KW  - Immunostimulant agents--interleukin 2--combined therapy;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Smith, J.A.
AU  - Goldspiel, B.R.
T1  - Cancer gene therapy update.
JO  - Journal of Oncology Pharmacy Practice
JF  - Journal of Oncology Pharmacy Practice
Y1  - 1999/03//
VL  - 5
IS  - 1
M3  - Article
SP  - 7
EP  - 21
PB  - Sage Publications, Ltd.
SN  - 10781552
AB  - Objective. To provide an update about gene marking and gene therapy trials in cancer patients. Data Sources. A MEDLINE search using the term “gene therapy” was conducted for the period 1985 to 1998. The reference lists from retrieved articles were reviewed. Meeting abstracts from the American Society of Clinical Oncology annual meeting (published in their proceedings) and the Annual Cancer Gene Therapy Symposium (published in Cancer Gene Therapy) that concerned gene therapy in cancer patients were also included. Data Extraction. Both authors reviewed the retrieved material and included preclinical data, case reports, and clinical trials related to gene transfer or gene therapy in cancer patients. Data Synthesis. There are several possible approaches to using gene therapy for the diagnosis and treatment of cancer and for the monitoring of cancer therapy. Exogenous genes may be used to mark cells to help better understand cancer biology or may be used directly for cancer treatment. Gene-marking trials have already provided new information about cancer biology and have demonstrated that reinfused progenitor cells may be a source of relapse in patients with acute or chronic myelogenous leukemia and neuroblastoma. Approaches using gene therapy for cancer treatment include: using lymphocytes as gene carriers, using foreign genes to increase tumor immunogenicity, introducing tumor regression antigen genes into viruses, introducing “sensitivity” genes to produce new cytotoxic agent(s) within tumors, producing new protein product(s) to protect normal cells, replacing missing or mutant tumor suppressor genes, and inactivating oncogenes. Clinical trials using these strategies have demonstrated that gene transfer is feasible (albeit with low transduction efficiency) and that gene expression occurs; in addition, clinical responses have been noted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Oncology Pharmacy Practice is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER -- Gene therapy
KW  - GENE therapy
KW  - GENETIC transformation
KW  - cancer
KW  - Gene therapy
KW  - gene transfer
KW  - retroviral vector
KW  - tumor targeting.
N1  - Accession Number: 5003786; Smith, J.A. 1 Goldspiel, B.R. 1; Affiliation:  1: From the National Institutes of Health Clinical Center, Pharmacy Department, Bethesda, Maryland.; Source Info: Mar1999, Vol. 5 Issue 1, p7; Subject Term: CANCER -- Gene therapy; Subject Term: GENE therapy; Subject Term: GENETIC transformation; Author-Supplied Keyword: cancer; Author-Supplied Keyword: Gene therapy; Author-Supplied Keyword: gene transfer; Author-Supplied Keyword: retroviral vector; Author-Supplied Keyword: tumor targeting.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 15p; Illustrations: 4 Diagrams, 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Lou, Q.
AU  - Pastan, I.
T1  - A Lewis[sup y] epitope mimicking peptide induces anti-Lewis[sup y] immune responses in rabbits and mice.
JO  - Journal of Peptide Research
JF  - Journal of Peptide Research
Y1  - 1999/03//
VL  - 53
IS  - 3
M3  - Article
SP  - 252
EP  - 260
PB  - Wiley-Blackwell
SN  - 1397002X
AB  - Lewis[sup y] carbohydrate antigens are abundant on the surface of many carcinomas. Mab B3 directed against this carbohydrate antigen has been used to make an immunotoxin that is very cytotoxic to cancer cells expressing the Lewis[sup y] antigen. Mab B3 was also used to screen a phage-displayed peptide library and identified a peptide mimicking the Lewis[sup y] epitope. In this report, we demonstrate that the Lewis[sup y] epitope-mimicking peptide induces anti-Lewis[sup y] immune responses in both rabbits and mice. In addition, Lewis[sup y] antigens induce anti-peptide immune responses. These results indicate that carbohydrate-mimicking peptides provide a novel strategy to elicit immune responses for tumor-associated carbohydrates. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Peptide Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANTIGENIC determinants
KW  - IMMUNE system
KW  - RABBITS -- Physiology
KW  - MICE -- Physiology
KW  - carbohydrate antigen
KW  - immunotoxin
KW  - mAb B3
N1  - Accession Number: 5169248; Lou, Q. 1 Pastan, I. 1; Affiliation:  1: Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 37 Convent DR MSC 4255, Bethesda MD 20892–4255, USA; Source Info: Mar1999, Vol. 53 Issue 3, p252; Subject Term: ANTIGENIC determinants; Subject Term: IMMUNE system; Subject Term: RABBITS -- Physiology; Subject Term: MICE -- Physiology; Author-Supplied Keyword: carbohydrate antigen; Author-Supplied Keyword: immunotoxin; Author-Supplied Keyword: mAb B3; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112930 Fur-Bearing Animal and Rabbit Production; NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 9p; Document Type: Article
L3  - 10.1034/j.1399-3011.1999.00025.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107179357
T1  - Observations. Entering the era of molecular dentistry.
AU  - Slavkin HC
Y1  - 1999/03//
N1  - Accession Number: 107179357. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Research, Medical
KW  - Genetics
KW  - Chromosome Disorders
KW  - Disease -- Familial and Genetic
SP  - 413
EP  - 417
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 3
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Dr, MSC 2290, Bldg 31, Rm 2C39, Bethesda, Md
U2  - PMID: 10085665.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Tomarev, Stanislav
T1  - Editorial: From Drosophila mutants to human diseases.
JO  - Ophthalmic Genetics
JF  - Ophthalmic Genetics
Y1  - 1999/03//
VL  - 20
IS  - 1
M3  - Editorial
SP  - 1
EP  - 6
PB  - Taylor & Francis Ltd
SN  - 13816810
AB  - Editorial.  Introduces a series of articles on ophthalmic genetics published in the March 1999 issue of `Ophthalmic Genetics.'
KW  - GENETICS
KW  - OPHTHALMOLOGY
N1  - Accession Number: 4589133; Tomarev, Stanislav 1; Affiliation:  1: National Eye Institute, NIH, Laboratory of Molecular and Developmental Biology, USA, Maryland<?PUB>, Bethesda, MD; Source Info: Mar1999, Vol. 20 Issue 1, p1; Subject Term: GENETICS; Subject Term: OPHTHALMOLOGY; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Editorial
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chhabra, R. S.
AU  - Maronpot, R. M.
AU  - Bucher, J. R.
AU  - Haseman, J. K.
AU  - Toft, J. D.
AU  - Hejtmancik, M. R.
T1  - Toxicology and carcinogenesis studies of pentachlorophenol in rats.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/03//
VL  - 48
IS  - 1
M3  - Article
SP  - 14
EP  - 20
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Pentachlorophenol (PCP) has been used as an herbicide, algaecide, defoliant, wood preservative, germicide, fungicide, and molluscicide. A 28-day toxicity study of PCP in F344N rats of both sexes was conducted to select dose levels for carcinogenicity study. Groups of 10 male and 10 female rats were given 0, 200, 400, 700, 1600 or 3200 ppm PCP in feed for 28 days. The incidences of minimal to mild hepatocyte degeneration in males and females exposed to 400 ppm or greater and the incidences of centrilobular hepatocyte hypertrophy in the 3200-ppm groups were increased. For carcinogenicity studies, groups of 50 male and 50 female F344/N rats were fed diets containing 200, 400, or 600 PCP for 2 years. A top-exposure group of 60 male and 60 female rats received 1000 ppm of PCP in feed for 52 weeks and control feed thereafter for the remainder of the 2-year studies; 10 male and 10 female rats were evaluated at 7 months. Survival of 600-ppm males was significantly greater than that of the controls; survival of all other exposed groups was similar to that of the control groups. Mean body weights of the 400- and 600-ppm groups were generally less than those of the controls throughout the studies. There was no evidence of carcinogenic activity of PCP in male or female rats fed diets containing 200, 400, or 600 ppm for 2 years. Stop-exposure study males and females regained a transitory body weight reduction by the end of the 2 year study, and males had better survival than the controls. At a 7-month interim evaluation, the incidences of centrilobular hypertrophy in stop-exposure males and females exceeded those in the controls. At 2 years, malignant mesothelioma originating from the tunica vaginalis was present in 9 1000-ppm males and 1 control male (p = 0.014). Nasal squamous cell carcinomas were present in five 1000-ppm males and 1 control male. This incidence was not significantly increased but exceeded the historical control range (0-4%). Based on the increased incidences of mesotheliomas and nasal tumors, there was some evidence of carcinogenic activity of PCP in male rats given a diet containing 1000 ppm for 1 year followed by control diet for 1 year. There was no evidence of PCP carcinogenic activity in stop-exposure female rats. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Pentachlorophenol
KW  - Carcinogenicity
KW  - Carcinogenicity testing
KW  - Mesothelioma
KW  - Liver cells
KW  - liver toxicity
KW  - mesothelioma
KW  - nasal tumors
KW  - pentachlorophenol
KW  - pentachlorophenol carcinogenicity
N1  - Accession Number: 44405720; Chhabra, R. S. 1; Maronpot, R. M. 2; Bucher, J. R. 2; Haseman, J. K. 2; Toft, J. D. 3; Hejtmancik, M. R. 3; Affiliations: 1: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709; 2: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 3: Battelle Laboratories, Columbus, Ohio 43201; Issue Info: Mar1999, Vol. 48 Issue 1, p14; Thesaurus Term: Pentachlorophenol; Thesaurus Term: Carcinogenicity; Thesaurus Term: Carcinogenicity testing; Subject Term: Mesothelioma; Subject Term: Liver cells; Author-Supplied Keyword: liver toxicity; Author-Supplied Keyword: mesothelioma; Author-Supplied Keyword: nasal tumors; Author-Supplied Keyword: pentachlorophenol; Author-Supplied Keyword: pentachlorophenol carcinogenicity; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Mahler, Joel F.
AU  - Price Jr., Herman C.
AU  - O'Connor, Robert W.
AU  - Wilson, Ralph E.
AU  - Eldridge, Sandra R.
AU  - Moorman, Michael P.
AU  - Morgan, Daniel L.
T1  - Characterization of hepatocellular resistance and susceptibility to styrene toxicity in B6C3F1 mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/03//
VL  - 48
IS  - 1
M3  - Article
SP  - 123
EP  - 133
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Short-term inhalation exposure of B6C3F1 mice to styrene causes necrosis of centrilobular (CL) hepatocytes. However, in spite of continued exposure, the necrotic parenchyma is rapidly regenerated, indicating resistance by regenerated cells to styrene toxicity. These studies were conducted to test the hypothesis that resistance to repeated styrene exposure is due to sustained cell proliferation, with production of hepatocytes that have reduced metabolic capacity. Male mice were exposed to air or 500 ppm styrene (6 h/day); hepatotoxicity was evaluated by microscopic examination, serum liver enzyme levels, and bromodeoxyuridine (BrdU)-labeling index (LI). Metabolism was assessed by measurement of blood styrene and styrene oxide. Both single and repeated exposures to styrene resulted in mortality by Day 2; in mice that survived, there was CL necrosis with elevated BrdU LI at Day 6, and complete restoration of the necrotic parenchyma by Day 15. The BrdU LI in mice given a single exposure of these mice on Day 15 resulted in additional mortality and hepatocellular necrosis, indicating that regenerated CL cells were again susceptible to the cytolethal effect of styrene following a 14-day recovery. However, in mice repeatedly exposed to styrene for 14 days, the BrdU LI remained significantly increased on Day 15, with preferential labeling of CL hepatocytes with enlarged nuclei (karyomegaly). If repeated exposures were followed by a 10-day recovery period, CL karyomegaly persisted, but the BrdU LI returned to control level and CL hepatocytes became susceptible again to styrene toxicity, as demonstrated by additional mortality and acute necrosis after a challenge exposure. These findings indicated a requirement for continued styrene exposure and DNA synthesis in order to maintain this resistant phenotype. Analyses of proliferating-cell nuclear-antigen (PCNA) labeling were conducted to further characterize the cell cycle kinetics of these hepatocytes. The proportion of cells in S-phase was increased by repeated exposure. However, PCNA analysis also revealed an even larger increase in the G1 cell compartment with repeated exposures, without a concurrent increase in G2 phase or in mitotic cell numbers. These data indicate that resistance to styrene-induced necrosis under conditions of repeated exposure is not due to sustained cell turnover and production of new, metabolically inactive cells, but rather is due to some other, as yet unknown, protective phenotype of the regenerated cells. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Antigens
KW  - Transgenic mice
KW  - Liver cells
KW  - Styrene
KW  - Cell proliferation
KW  - cell cycle
KW  - hepatotoxicity
KW  - mouse
KW  - regeneration
KW  - styrene
N1  - Accession Number: 44405733; Mahler, Joel F. 1; Price Jr., Herman C. 2; O'Connor, Robert W. 2; Wilson, Ralph E. 1; Eldridge, Sandra R. 3; Moorman, Michael P. 1; Morgan, Daniel L. 1; Email Address: morgan_d@niehs.nih.gov; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: ManTech Environmental Technology, Inc., Research Triangle Park, North Carolina 27709; 3: Pathology Associates, Inc., Research Triangle Park, North Carolina 27709; Issue Info: Mar1999, Vol. 48 Issue 1, p123; Thesaurus Term: Antigens; Subject Term: Transgenic mice; Subject Term: Liver cells; Subject Term: Styrene; Subject Term: Cell proliferation; Author-Supplied Keyword: cell cycle; Author-Supplied Keyword: hepatotoxicity; Author-Supplied Keyword: mouse; Author-Supplied Keyword: regeneration; Author-Supplied Keyword: styrene; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 11p; Illustrations: 3 Diagrams, 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107210821
T1  - Evaluation of the gel system for ABO grouping and D typing.
AU  - Langston MM
AU  - Procter JL
AU  - Cipolone KM
AU  - Stroncek DF
Y1  - 1999/03//
N1  - Accession Number: 107210821. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - Blood Grouping and Crossmatching -- Methods
KW  - ABO Blood-Group System -- Immunology
KW  - Immunologic Tests -- Methods
KW  - Isoantibodies
KW  - Rh-Hr Blood-Group System -- Immunology
KW  - Gels
KW  - Sensitivity and Specificity
KW  - Anticoagulants
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Human
SP  - 300
EP  - 305
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 39
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - Medical Technologist, Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1184
U2  - PMID: 10204594.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107210821&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2006-00314-008
AN  - 2006-00314-008
AU  - Horwitz, Barry
AU  - Tagamets, M. -A.
AU  - McIntosh, Anthony Randal
T1  - Neural modeling, functional brain imaging, and cognition.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1999/03//
VL  - 3
IS  - 3
SP  - 91
EP  - 98
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Horwitz, Barry, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bldg 10, Rm 6C414, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1  - Accession Number: 2006-00314-008. PMID: 10322460 Partial author list: First Author & Affiliation: Horwitz, Barry; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20060417. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Cognition; Magnetic Resonance Imaging; Neuroimaging; Simulation. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Methodology: Brain Imaging. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 1999. 
AB  - The richness and complexity of data sets acquired from PET or fMRI studies of human cognition have not been exploited until recently by computational neural-modeling methods. In this article, two neural-modeling approaches for use with functional brain imaging data are described. One, which uses structural equation modeling, estimates the functional strengths of the anatomical connections between various brain regions during specific cognitive tasks. The second employs large-scale neural modeling to relate functional neuroimaging signals in multiple, interconnected brain regions to the underlying neurobiological time-varying activities in each region. Delayed match-to-sample (visual working memory for form) tasks are used to illustrate these models. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neural modeling
KW  - functional brain imaging
KW  - cognition
KW  - neuroimaging
KW  - magnetic resonance imaging
KW  - 1999
KW  - Brain
KW  - Cognition
KW  - Magnetic Resonance Imaging
KW  - Neuroimaging
KW  - Simulation
KW  - 1999
DO  - 10.1016/S1364-6613(99)01282-6
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UR  - horwitz@helix.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13486-005
AN  - 2008-13486-005
AU  - Safieddine, Saaid
AU  - Wenthold, Robert J.
T1  - SNARE complex at the ribbon synapses of cochlear hair cells: Analysis of synaptic vesicle- and synaptic membrane-associated proteins.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1999/03//
VL  - 11
IS  - 3
SP  - 803
EP  - 812
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Safieddine, Saaid, NIDCD/NIH, Bldg 36/Room 5D08, 36 Convent Drive MSC-4162, Bethesda, MD, US, 20892-4162
N1  - Accession Number: 2008-13486-005. PMID: 10103074 Partial author list: First Author & Affiliation: Safieddine, Saaid; Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090323. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cochlea; Membranes; Proteins; Synapses; Synaptic Vesicle. Minor Descriptor: Guinea Pigs; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar, 1999. 
AB  - Neurotransmitters are released via exocytosis of synaptic vesicles involving a fusion complex consisting of a set of highly conserved proteins, which form a multiprotein complex resulting in the docking of synaptic vesicles at the site of release. There are three major differences between cochlear hair cell synapses and CNS synapses: (i) hair cells have a specialized structure, the synaptic ribbon, to which synaptic vesicles are attached; (ii) hair cells can maintain high and sustained release of neurotransmitter; and (iii) hair cells lack synaptophysin and synapsin. These differences suggest that an unconventional mechanism of neurotransmitter release may be involved at ribbon synapses. In this study we used different and complementary approaches to determine whether or not ribbon-containing hair cells of the cochlea express any component of the core fusion complex found in conventional synapses. Syntaxin 1, the synaptic membrane synaptosome-associated protein (SNAP)-25 and vesicle-associated membrane protein (VAMP or synaptobrevin) were found to be present in the organ of Corti of both rat and guinea-pig, as shown by reverse transcription polymerase chain reaction and Western blotting. In situ hybridization and immunocytochemistry showed mRNA and protein expression, respectively, in both inner and outer hair cells. Synaptotagmins I and II, generally considered to play major roles in neurotransmitter release at central synapses, were not detected in the organ of Corti. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - SNARE complex
KW  - cochlear hair cells
KW  - synaptic vesicles
KW  - synaptic membranes
KW  - proteins
KW  - ribbon synapses
KW  - syntaxin 1
KW  - synaptobrevin
KW  - guinea pigs
KW  - rats
KW  - 1999
KW  - Cochlea
KW  - Membranes
KW  - Proteins
KW  - Synapses
KW  - Synaptic Vesicle
KW  - Guinea Pigs
KW  - Rats
KW  - 1999
DO  - 10.1046/j.1460-9568.1999.00487.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13486-005&site=ehost-live&scope=site
UR  - safieddi@nidcd.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2008-13486-013
AN  - 2008-13486-013
AU  - Bengzon, Johan
AU  - Okabe, Shigeo
AU  - Lindvall, Olle
AU  - McKay, Ronald D. G.
T1  - Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1999/03//
VL  - 11
IS  - 3
SP  - 916
EP  - 922
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
AD  - Bengzon, Johan, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S-221 85, Lund, Sweden
N1  - Accession Number: 2008-13486-013. PMID: 10103085 Partial author list: First Author & Affiliation: Bengzon, Johan; Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden. Other Publishers: Blackwell Publishing. Release Date: 20090323. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Bengzon, Johan. Major Descriptor: Epileptic Seizures; Experimental Epilepsy; Kindling; N-Methyl-D-Aspartate; Neural Receptors. Minor Descriptor: Mice. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Mar, 1999. 
AB  - The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded and generalized seizures appeared later in animals over expressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - epileptogenesis
KW  - N-methyl-D-aspartate receptors
KW  - kindling
KW  - seizure development
KW  - NR2D subunit
KW  - mice
KW  - 1999
KW  - Epileptic Seizures
KW  - Experimental Epilepsy
KW  - Kindling
KW  - N-Methyl-D-Aspartate
KW  - Neural Receptors
KW  - Mice
KW  - 1999
U1  - Sponsor: Medical Research Council, Sweden. Recipients: No recipient indicated
U1  - Sponsor: Magnus Bergvall Foundation. Recipients: No recipient indicated
U1  - Sponsor: Rut and Erik Hardebo Foundation. Recipients: No recipient indicated
U1  - Sponsor: Greta and Johan Kock Foundation. Recipients: No recipient indicated
U1  - Sponsor: Elsa Schmitz Foundation. Recipients: No recipient indicated
U1  - Sponsor: Elsa and Thorsten Segerfalk Foundation. Recipients: No recipient indicated
U1  - Sponsor: Åke Wiberg and Thelma Zoega Foundation. Recipients: No recipient indicated
U1  - Sponsor: Royal Physiographic Society. Recipients: No recipient indicated
U1  - Sponsor: Swedish Association of Neurologically Disabled, Sweden. Recipients: No recipient indicated
U1  - Sponsor: Society of Swedish Physicians, Sweden. Recipients: No recipient indicated
U1  - Sponsor: Swedish Society for Medical Research, Sweden. Recipients: Bengzon, Johan
DO  - 10.1046/j.1460-9568.1999.00500.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13486-013&site=ehost-live&scope=site
UR  - 
UR  - ORCID: 0000-0001-6536-2107
UR  - johan.bengzon@neurol.lu.se
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42597-009
AN  - 2015-42597-009
AU  - Wang, Zuo-Zhong
AU  - Mathias, Askale
AU  - Gautam, Medha
AU  - Hall, Zach W.
T1  - Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/03//
VL  - 19
IS  - 6
SP  - 1998
EP  - 2007
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wang, Zuo-Zhong, Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, E1440 BST, Pittsburgh, PA, US, 15261
N1  - Accession Number: 2015-42597-009. PMID: 10066253 Partial author list: First Author & Affiliation: Wang, Zuo-Zhong; Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Acetylcholine; Cholinergic Receptors; Nicotine; Phosphorylation. Minor Descriptor: Mice; Muscles. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Mar, 1999. Publication History: Accepted Date: Jan 6, 1999; Revised Date: Dec 22, 1998; First Submitted Date: Aug 18, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Although the metabolic half-life of muscle endplate acetylcholine receptor (AChR) changes during development and after denervation in the adult, little is known about the molecular mechanisms that influence receptor stability. We have investigated the effect on AChR turnover of its interaction with rapsyn, a 43 kDa peripheral membrane protein that is closely associated with the AChR in muscle cells and is required for its clustering at endplates. Both in transfected COS cells and in cultured myotubes from rapsyn-negative and rapsyn-positive mice, we have found that the presence of rapsyn slows the turnover of AChRs by as much as twofold. The effect was similar for both embryonic (α₂βδγ) and adult (α₂βδε) AChRs and for AChRs whose β subunit lacked a putative tyrosine phosphorylation site. Neither colchicine nor cytochalasin D altered AChR turnover or prevented the rapsyn effect. Mutant rapsyn proteins whose N-terminal myristoylation signal was eliminated, or whose C terminus or zinc-finger domains were deleted, failed to change the rate of receptor turnover. Each of these mutations affects the association of the AChR with rapsyn, suggesting that AChR stability is altered by interaction between the two proteins. Our results suggest that, in addition to its role in AChR clustering, rapsyn also functions to metabolically stabilize the AChR. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - nicotinic receptors
KW  - rapsyn
KW  - 43 kDa protein
KW  - receptor turnover
KW  - acetylcholine
KW  - neuromuscular junction
KW  - endplate
KW  - myotubes
KW  - 1999
KW  - Acetylcholine
KW  - Cholinergic Receptors
KW  - Nicotine
KW  - Phosphorylation
KW  - Mice
KW  - Muscles
KW  - 1999
U1  - Sponsor: Muscular Dystrophy Association. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, US. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-42597-009&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42597-019
AN  - 2015-42597-019
AU  - Fedirchuk, Brent
AU  - Wenner, Peter
AU  - Whelan, Patrick J.
AU  - Ho, Stephen
AU  - Tabak, Joel
AU  - O'Donovan, Michael J.
T1  - Spontaneous network activity transiently depresses synaptic transmission in the embryonic chick spinal cord.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/03//
VL  - 19
IS  - 6
SP  - 2102
EP  - 2112
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - O'Donovan, Michael J., Laboratory of Neural Control, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 49, Room 3A50, 49 Convent Drive, Bethesda, MD, US, 20892-4455
N1  - Accession Number: 2015-42597-019. PMID: 10066263 Partial author list: First Author & Affiliation: Fedirchuk, Brent; Department of Physiology, University of Manitoba, Winnipeg, MB, Canada. Release Date: 20160922. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Fedirchuk, Brent. Major Descriptor: Evoked Potentials; Neurotransmission; Spinal Cord; Synapses; Biological Neural Networks. Minor Descriptor: Ligand. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Mar, 1999. Publication History: Accepted Date: Jan 5, 1999; Revised Date: Dec 28, 1998; First Submitted Date: Aug 26, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - We examined the effects of spontaneous or evoked episodes of rhythmic activity on synaptic transmission in several spinal pathways of embryonic day 9–12 chick embryos.We compared the amplitude of synaptic potentials evoked by stimulation of the ventrolateral funiculus (VLF), the dorsal or ventral roots, before and after episodes of activity. With the exception of the short-latency responses evoked by dorsal root stimulation, the potentials were briefly potentiated and then reduced for several minutes after an episode of rhythmic activity. Their amplitude progressively recovered in the interval between successive episodes. The lack of post-episode depression in the short-latency component of the dorsal root evoked responses is probably attributable to the absence of firing in cut muscle afferents during an episode of activity. The post-episode depression of VLF-evoked potentials was mimicked by prolonged stimulation of the VLF, subthreshold for an episode of activity. By contrast, antidromically induced motoneuron firing and the accompanying calcium entry did not depress VLF-evoked potentials recorded from the stimulated ventral root. In addition, post-episode depression of VLF-evoked synaptic currents was observed in voltage-clamped spinal neurons. Collectively, these findings suggest that somatic postsynaptic activity and calcium entry are not required for the depression. We propose instead that the mechanism may involve a form of long-lasting activity-induced synaptic depression, possibly a combination of transmitter depletion and ligand-induced changes in the postsynaptic current accompanying transmitter release. This activity-dependent depression appears to be an important mechanism underlying the occurrence of spontaneous activity in developing spinal networks. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - synaptic depression
KW  - spontaneous activity
KW  - spinal networks
KW  - synaptic currents
KW  - chick embryo
KW  - rhythmic activity
KW  - 1999
KW  - Evoked Potentials
KW  - Neurotransmission
KW  - Spinal Cord
KW  - Synapses
KW  - Biological Neural Networks
KW  - Ligand
KW  - 1999
U1  - Sponsor: Medical Research Council, Canada. Other Details: Fellowship. Recipients: Fedirchuk, Brent
U1  - Sponsor: Natural Sciences and Engineering Research Council, Canada. Other Details: Fellowship. Recipients: Whelan, Patrick J.
U1  - Sponsor: Alberta Heritage Foundation for Medical Research, Canada. Other Details: Fellowship. Recipients: Whelan, Patrick J.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-42597-019&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42597-027
AN  - 2015-42597-027
AU  - Aley, Kochuvelikakam O.
AU  - Levine, Jon D.
T1  - Role of protein kinase A in the maintenance of inflammatory pain.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/03//
VL  - 19
IS  - 6
SP  - 2181
EP  - 2186
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Levine, Jon D., National Institutes of Health Pain Center, University of California, San Francisco, C-522, Box 0440, 521 Parnassus Avenue, San Francisco, CA, US, 94143-0440
N1  - Accession Number: 2015-42597-027. PMID: 10066271 Partial author list: First Author & Affiliation: Aley, Kochuvelikakam O.; Department of Anatomy, Neuroscience Program, National Institutes of Health Pain Center, University of California, San Francisco, CA, US. Release Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Kinases; Pain; Proteins; Adenylyl Cyclase. Minor Descriptor: Inflammation; Somatosensory Disorders. Classification: Physiological Processes (2540). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 6. Issue Publication Date: Mar, 1999. Publication History: Accepted Date: Dec 22, 1998; Revised Date: Dec 17, 1998; First Submitted Date: Aug 27, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Although the initiation of inflammatory pain (hyperalgesia) has been demonstrated to require the cAMP second messenger signaling cascade, whether this mechanism and/or other mechanisms underlie the continued maintenance of the induced hyperalgesia is unknown. We report that injection of adenylyl cyclase inhibitors before but not after injection of direct-acting hyperalgesic agents (prostaglandin E₂ and purine and serotonin receptor agonists) resulted in reduction in hyperalgesia, evaluated by the Randall–Selitto paw-withdrawal test. In contrast, injection of protein kinase A (PKA) inhibitors either before or after these hyperalgesic agents resulted in reduced hyperalgesia, suggesting that hyperalgesia after its activation was maintained by persistent PKA activity but not by adenylyl cyclase activity. To evaluate further the role of PKA activity in the maintenance of hyperalgesia, we injected the catalytic subunit of PKA (PKACS) that resulted in hyperalgesia similar in magnitude to that induced by the direct-acting hyperalgesic agents but much longer in duration (>48 vs 2 hr). Injection of WIPTIDE (a PKA inhibitor) at 24 hr after PKACS reduced hyperalgesia, suggesting that PKACS hyperalgesia is not independently maintained by steps downstream from PKA. In summary, our results indicate that, once established, inflammatory mediator-induced hyperalgesia is no longer maintained by adenylyl cyclase activity but rather is dependent on ongoing PKA activity. An understanding of the mechanism maintaining hyperalgesia may provide important insight into targets for the treatment of persistent pain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - adenylyl cyclase
KW  - cAMP
KW  - hyperalgesia
KW  - pain
KW  - protein kinase A
KW  - prostaglandin E2
KW  - 1999
KW  - Kinases
KW  - Pain
KW  - Proteins
KW  - Adenylyl Cyclase
KW  - Inflammation
KW  - Somatosensory Disorders
KW  - 1999
U1  - Sponsor: National Institutes of Health, US. Grant: NS21647. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-42597-027&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107205376
T1  - Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus.
AU  - Henderson DK
AU  - Henderson, D K
Y1  - 1999/03/10/
N1  - Accession Number: 107205376. Language: English. Entry Date: 19990801. Revision Date: 20161112. Publication Type: journal article; review. Commentary: Bangsberg D, Goldschmidt R H. Postexposure prophylaxis for occupational exposure to HIV. (JAMA) 11/3/99; 282 (17): 1623-1624. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Postexposure Follow-Up
KW  - HIV Infections -- Prevention and Control
KW  - Health Personnel, Infected -- Prevention and Control
KW  - Antiviral Agents -- Therapeutic Use
SP  - 931
EP  - 936
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 281
IS  - 10
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - Office of the Deputy Director for Clinical Care, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1504, USA
AD  - Bldg 10, Room 2C146, National Institutes of Health, 10 Center Dr, MSC-1504, Bethesda, MD 20892-1504 (e-mail: dkh@nih.gov)
U2  - PMID: 10078491.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107205376&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Henderson, D. K.;
T1  - Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus
CT  - Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus
JO  - Journal of the American Medical Association (USA)
JF  - Journal of the American Medical Association (USA)
Y1  - 1999/03/10/
VL  - 281
IS  - Mar 10
SP  - 931
EP  - 936
SN  - 00987484
AD  - National Inst. of Hlth., Bldg. 10, Rm 2C146, 10 Center Dr., MSC-1504, Bethesda, MD 20892-1504, USA Internet: dkh@nih.gov
N1  - Accession Number: 36-05260; Language: English; References: 63; Publication Type: Review; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Environmental Toxicity; Abstract Author: Peggy L. Ruppel
N2  - A review of the published literature regarding investigational and currently approved antiretroviral agents in the prophylaxis of human immunodeficiency virus (HIV) infection in health care workers following occupational exposure is presented. A protocol for antiretroviral prophylaxis in the event of occupational exposure is included.
KW  - Antiretroviral agents--HIV infections--occupational exposure;
KW  - HIV infections--antiretroviral agents--occupational exposure;
KW  - Health professions--antiretroviral agents--HIV infections;
KW  - Protocols--antiretroviral agents--HIV infections;
KW  - Toxicity, environmental--HIV infections--antiretroviral protocols;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=36-05260&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107187160
T1  - Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia.
AU  - Walsh TJ
AU  - Finberg RW
AU  - Arndt C
AU  - Hiemenz J
AU  - Schwartz C
AU  - Bodensteiner D
AU  - Pappas P
AU  - Seibel N
AU  - Greenberg RN
AU  - Dummer S
AU  - Schuster M
AU  - Holcenberg JS
Y1  - 1999/03/11/
N1  - Accession Number: 107187160. Corporate Author: National Institute of Allergy and Infectious Diseases Mycoses Study Group. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by a grant (N01-A1-65296) from the National Institute of Allergy and Infectious Diseases, National Institute of Health, and by Fujusawa USA, Deerfield, Ill. NLM UID: 0255562. 
KW  - Fever -- Drug Therapy
KW  - Neutropenia -- Drug Therapy
KW  - Amphotericin B -- Therapeutic Use
KW  - Amphotericin B -- Adverse Effects
KW  - Funding Source
KW  - Double-Blind Studies
KW  - Random Assignment
KW  - Mantel-Haenszel Test
KW  - Fisher's Exact Test
KW  - Confidence Intervals
KW  - Kaplan-Meier Estimator
KW  - P-Value
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 764
EP  - 771
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 340
IS  - 10
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Bldg 10, Rm 13N-240, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 10072411.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107187160&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Cacalano, Nicholas A.
AU  - Migone, Thi-Sau
AU  - Bazan, Fernando
AU  - Hanson, Eric P.
AU  - Chen, Min
AU  - Candotti, Fabio
AU  - O'Shea, John J.
AU  - Johnston, James A.
T1  - Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/03/15/
VL  - 18
IS  - 6
M3  - Article
SP  - 1549
EP  - 1558
SN  - 02614189
AB  - Signaling through the hematopoietic receptors requires activation of receptor-associated Janus (Jak) kinases. For example, Jak1 and Jak3 bind specifically to the IL-2 receptor beta (IL-2Rβ) and common gamma (γc) chains, respectively, and initiate biochemical signals critical in controlling immune responses. The region of Jak responsible for receptor interactions, however, is not well characterized. Here we describe a naturally occurring Jak3 mutation from a patient with autosomal severe combined immunodeficiency (SCID), where a single amino acid substitution, Y100C, in Janus homology domain 7 (JH7) prevents kinase­receptor interaction. This mutation also results in a loss of IL-2-induced signaling in a B-cell line derived from this patient. Using mutational analysis we have identified a region of Jak3, including portions of JH6 and JH7, that is sufficient for kinase­receptor contact and show that this segment interacts with the proline-rich Box1 region of the receptor. Furthermore, a Jak3­Jak1 chimera containing only the JH6 and JH7 domains of Jak3 interacts with γc and can reconstitute IL-2-dependent responses, including receptor phosphorylation and activation of signal transducer and activator of transcription (STAT) 5b. Our results suggest that the N-terminus of Jak kinases is critical for receptor binding, and is therefore likely to determine specificity of Jak kinase­receptor interactions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HEMATOPOIESIS
KW  - CYTOKINES
KW  - PROTEINS
KW  - IMMUNODEFICIENCY
KW  - IMMUNE response
KW  - AMINO acids
KW  - PROLINE
KW  - common gamma chain
KW  - interleukin-2
KW  - jak kinase
KW  - jak3
KW  - receptor
N1  - Accession Number: 13003940; Cacalano, Nicholas A. 1 Migone, Thi-Sau 1 Bazan, Fernando 1 Hanson, Eric P. 2 Chen, Min 2 Candotti, Fabio 3 O'Shea, John J. 1 Johnston, James A. 1; Email Address: johnston@dnax.org; Affiliation:  1: DNAX Research Institute, Palo, Alto, CA  2: Lymphocyte Cell Biology Section, Arthritis-Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA  3: Clinical Gene Therapy Branch, NHGRI, National Institutes of Health, Bethesda, MD, USA; Source Info: 3/15/99, Vol. 18 Issue 6, p1549; Subject Term: HEMATOPOIESIS; Subject Term: CYTOKINES; Subject Term: PROTEINS; Subject Term: IMMUNODEFICIENCY; Subject Term: IMMUNE response; Subject Term: AMINO acids; Subject Term: PROLINE; Author-Supplied Keyword: common gamma chain; Author-Supplied Keyword: interleukin-2; Author-Supplied Keyword: jak kinase; Author-Supplied Keyword: jak3; Author-Supplied Keyword: receptor; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/18.6.1549
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003940&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Asano, Katsura
AU  - Krishnamoorthy, Thanuja
AU  - Phan, Lon
AU  - Pavitt, Graham D.
AU  - Hinnebusch, Alan G.
T1  - Conserved bipartite motifs in yeast eIF5 and eIF2Be, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/03/15/
VL  - 18
IS  - 6
M3  - Article
SP  - 1673
EP  - 1688
SN  - 02614189
AB  - In the initiation phase of eukaryotic translation, eIF5 stimulates the hydrolysis of GTP bound to eIF2 in the 40S ribosomal pre-initiation complex, and the resultant GDP on eIF2 is replaced with GTP by the complex nucleotide exchange factor, eIF2B. Bipartite motifs rich in aromatic and acidic residues are conserved at the C-termini of eIF5 and the catalytic (ε) subunit of eIF2B. Here we show that these bipartite motifs are important for the binding of these factors, both in vitro and in vivo, to the β subunit of their common substrate eIF2. We also find that three lysine-rich boxes in the N-terminal segment of eIF2β mediate the binding of eIF2 to both eIF5 and eIF2B. Thus, eIF5 and eIF2Bε employ the same sequence motif to facilitate interaction with the same segment of their common substrate. In agreement with this, archaea appear to lack eIF5, eIF2B and the lysine-rich binding domain for these factors in their eIF2β homolog. The eIF5 bipartite motif is also important for its interaction with the eIF3 complex through the NIP1-encoded subunit of eIF3. Thus, the bipartite motif in eIF5 appears to be multi-functional, stimulating its recruitment to the 40S preinitiation complex through interaction with eIF3 in addition to binding of its substrate eIF2. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - YEAST
KW  - PHENOTYPE
KW  - PROTEINS
KW  - GENES
KW  - GENETIC regulation
KW  - HYDROLYSIS
KW  - eif2
KW  - evolution of eifs
KW  - gap
KW  - gef
KW  - translation initiation complex
N1  - Accession Number: 13003929; Asano, Katsura 1 Krishnamoorthy, Thanuja 1 Phan, Lon 1 Pavitt, Graham D. 2 Hinnebusch, Alan G. 1; Email Address: ahinnebusch@nih.gov; Affiliation:  1: Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA  2: Deparment of Anatomy and Physiology, University of Dundee, Dundee, UK; Source Info: 3/15/99, Vol. 18 Issue 6, p1673; Subject Term: YEAST; Subject Term: PHENOTYPE; Subject Term: PROTEINS; Subject Term: GENES; Subject Term: GENETIC regulation; Subject Term: HYDROLYSIS; Author-Supplied Keyword: eif2; Author-Supplied Keyword: evolution of eifs; Author-Supplied Keyword: gap; Author-Supplied Keyword: gef; Author-Supplied Keyword: translation initiation complex; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 16p; Document Type: Article
L3  - 10.1093/emboj/18.6.1673
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13003929&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 106828175
T1  - Sympathetically maintained pain: has the emperor no clothes?
AU  - Max MB
AU  - Gilron I
Y1  - 1999/03/23/1999 Mar 23
N1  - Accession Number: 106828175. Language: English. Entry Date: 20030502. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0401060. 
KW  - Pain -- Physiology
KW  - Sympathetic Nervous System
KW  - Pain -- Therapy
KW  - Reflex Sympathetic Dystrophy -- Therapy
KW  - Nerve Block
SP  - 905
EP  - 907
JO  - Neurology
JF  - Neurology
JA  - NEUROLOGY
VL  - 52
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0028-3878
AD  - Pain Research Clinic, Building 10, Room 3C-405, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 10102403.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106828175&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107150620
T1  - Aging successfully until death in old age: opportunities for increasing active life expectancy.
AU  - Leveille SG
AU  - Guralnik JM
AU  - Ferrucci L
AU  - Langlois JA
Y1  - 1999/04//1999 Apr 1
N1  - Accession Number: 107150620. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653. 
KW  - Aging
KW  - Life Expectancy
KW  - Functional Status -- In Old Age
KW  - Epidemiological Research
KW  - Interviews
KW  - Prospective Studies
KW  - Geriatric Functional Assessment
KW  - Self Report
KW  - Kaplan-Meier Estimator
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Multiple Logistic Regression
KW  - P-Value
KW  - Chi Square Test
KW  - Sex Factors
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 654
EP  - 664
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 149
IS  - 7
PB  - Oxford University Press / USA
AB  - The purpose of this study was to estimate the prevalence of having no disability in the year prior to death in very old age and to examine factors associated with this outcome. Participants were men and women aged 65 years and older who were followed prospectively between 1981 and 1991 from three communities: New Haven, Connecticut; Iowa and Washington counties, Iowa; and East Boston, Massachusetts. Persons who died in late old age with known disability status within 15 months of death (n = 1,097) were studied for predictors of dying without disability at the last follow-up interview prior to death. The probability of a nondisabled 65-year-old man's surviving to age 80 and then being nondisabled prior to death was 26% and, for a 65-year-old woman, the probability of surviving to age 85 and being nondisabled before death was 18%. Physical activity was a key factor predicting nondisability before death. There was nearly a twofold increased likelihood of dying without disability among the most physically active group compared with sedentary adults (adjusted odds ratio = 1.86, 95% confidence interval 1.24-2.79). These findings provide encouraging evidence that disability prior to death is not an inevitable part of a long life but may be prevented by moderate physical activity.
SN  - 0002-9262
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Gateway Building, Suite 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892
U2  - PMID: 10192313.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kammula, U.S.
AU  - Marincola, F.M.
T1  - Cancer Immunotherapy: Is There Real Progress at Last?
JO  - BioDrugs
JF  - BioDrugs
Y1  - 1999/04//
VL  - 11
IS  - 4
M3  - Article
SP  - 249
EP  - 260
PB  - Springer Science & Business Media B.V.
SN  - 11738804
AB  - This review summarises the evolution of recent major advances in cancer immunotherapy, using metastatic melanoma as a model. The first true clinical progress with immunotherapy developed from the application of recombinant DNA technology for the large scale production of immunostimulant cytokines. Clinical trials demonstrated that the systemic administration of recombinant high-dose bolus intravenous interleukin-2 (IL-2; 720 000 IU/kg every 8 hours) mediated objective tumour progression in 20% of patients with metastatic renal cancer and in 17% of patients with metastatic melanoma, with complete responses of 9% and 7%, respectively. The use of adoptive immunotherapy (the transfer of immune cells with anti-tumour activity to the tumour-bearing host) focused interest on T lymphocyte-mediated tumour recognition. Clinical trials described the systemic administration of lymphokine activated killer (LAK) cells and subsequently tumour infiltrating lymphocytes (TIL) to patients with advanced cancer. Although able to kill tumour targets in vitro, LAK cells did not prove useful for the treatment of patients with metastatic melanoma and renal cancer. A randomised trial, in which IL-2 was administered alone or with LAK cells, failed to show a difference in response rate or survival. In contrast, the treatment of 86 patients with metastatic melanoma using TIL plus IL-2 resulted in a 34% objective response rate, which included patients who had previously failed treatment with high-dose IL-2 alone. The focus on cellular immune responses, combined with rapid biotechnological advances, resulted in the identification of tumour specific antigens, such as MART-1 and gp100, that could be recognised by autologous TIL. This provided fundamental evidence of the existence of melanoma-associated antigens that were recognised in vivo by effector cells of the immune system. In vitro studies demonstrated immunodominant epitopes from MART-1 and gp100 that could induce in vitro-specific cytotoxic T lymphocyte reactivity. To enhance in vitro immunogenicity, single amino acid substitutions were made to identify peptides with higher affinity for HLA-A*0201. Modified peptides from gp100 were compared with the parental peptide for increased immunogenicity based on their ability to induce anti-tumour lymphocytes in vitro. From these studies, a candidate peptide was identified (G9-209-2M) which had increased immunogenic reactivity in vitro. Clinical trials demonstrated that the modified G9-209-2M peptide was more effective. Unfortunately, objective tumour regression was still low. However, when high-dose IL-2 was combined with G9-209-2M objective clinical responses increased to 42%. Efforts to find better ways to immunise against self antigens are ongoing and involve further peptide immunisations, as well as recombinant viral vectors, adjuvant cytokine therapy and cellular adjuvants such as dendritic cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of BioDrugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANCER -- Immunotherapy
KW  - MELANOMA
KW  - CYTOKINES
KW  - Aldesleukin, therapeutic-use
KW  - Anticancer-vaccines, therapeutic-use
KW  - Antineoplastics, therapeutic-use
KW  - Biotechnology
KW  - Cancer, treatment
KW  - Immunotherapies, therapeutic-use
KW  - Malignant-melanoma, treatment
KW  - Melanoma-vaccine, therapeutic-use
KW  - Melanoma-vaccine-Genzyme-Molecular-Oncology, thera
KW  - Research-and-development
KW  - Reviews-on-treatment
KW  - Tumour-infiltrating-lymphocytes, therapeutic-use
N1  - Accession Number: 9522585; Kammula, U.S. 1 Marincola, F.M. 1; Affiliation:  1: Surgery Branch, Division of Clinical Sciences, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 1999, Vol. 11 Issue 4, p249; Subject Term: CANCER -- Immunotherapy; Subject Term: MELANOMA; Subject Term: CYTOKINES; Author-Supplied Keyword: Aldesleukin, therapeutic-use; Author-Supplied Keyword: Anticancer-vaccines, therapeutic-use; Author-Supplied Keyword: Antineoplastics, therapeutic-use; Author-Supplied Keyword: Biotechnology; Author-Supplied Keyword: Cancer, treatment; Author-Supplied Keyword: Immunotherapies, therapeutic-use; Author-Supplied Keyword: Malignant-melanoma, treatment; Author-Supplied Keyword: Melanoma-vaccine, therapeutic-use; Author-Supplied Keyword: Melanoma-vaccine-Genzyme-Molecular-Oncology, thera; Author-Supplied Keyword: Research-and-development; Author-Supplied Keyword: Reviews-on-treatment; Author-Supplied Keyword: Tumour-infiltrating-lymphocytes, therapeutic-use; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Secchi, Filippo E.
AU  - Lizak, Martin J.
AU  - Sato, Sanai
AU  - Kador, Peter F.
T1  - 3-Fluoro-3-deoxy-D-galactose: A new probe for studies on sugar cataract.
JO  - Current Eye Research
JF  - Current Eye Research
Y1  - 1999/04//
VL  - 18
IS  - 4
M3  - Article
SP  - 277
EP  - 282
PB  - Taylor & Francis Ltd
SN  - 02713683
AB  - Purpose. Aldose reductase (AR) activity and flux through the polyol pathway can conveniently be monitored in dog lenses by measuring the metabolism of 3-fluoro-3-deoxy-D-glucose by 19F nuclear magnetic resonance (NMR) spectroscopy. Since AR has broad substrate specificity and preferentially utilizes galactose over glucose as substrate, the ability of AR to utilize 3-fluoro-3-deoxy-D-galactose (3-FDGal) as substrate as well as the metabolism of 3-FDGal in intact dog lens and cultured lens epithelial cells has been investigated. Methods. The suitableness of 3FDGal as a substrate was examined by incubating 3FDGal with purified dog lens aldose reductase in the presence of an NADPH generating system or with galactitol dehydrogenase in the presence of NAD+. Dog lenses and dog lens epithelial cells were cultured in 3-FDGal medium with and without the AR inhibitor AL 1576. Metabolism was studied using 19F NMR. Results. AR activity with 3-FDGal as substrate is higher than that with D-galactose and its Km of 4.2 mM is ca 10-fold higher than that of D-galactose. Purified dog lens AR incubated with 3-FDGal resulted in the formation of 3-fluoro-3-deoxy-D-galactitol. Galactitol formation was prevented by the addition of AL 1576. Incubation of 3-FDGal with galactitol dehydrogenase resulted in the formation of 3-fluoro-3-deoxy-D-galactonic acid. Dog lenses cultured in 3-FDGal medium formed NMR peaks corresponding to 3-fluoro-3-deoxy-D-galactitol and 3-fluoro-3-deoxy-D-galactonic acid. The presence of AL 1576 inhibited the formation of galactitol but not galactonic acid. Lens epithelial cells cultured in 3-FDGal medium formed only 3-fluoro-3-deoxy-D-galactitol. These cells developed multiple cytoplasmic vacuoles which was prevented by the aldose reductase inhibitor AL 1576. Conclusions. The high affinity of this fluorinated sugar for aldose reductase makes this an excellent probe for investigating aldose reductase activity in dog lens tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Current Eye Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALDOSE reductase
KW  - POLYOLS
KW  - NUCLEAR magnetic resonance spectroscopy
KW  - EPITHELIAL cells
KW  - CATARACT
KW  - DIAGNOSIS
KW  - aldose reductase
KW  - dog
KW  - lens
N1  - Accession Number: 4663838; Secchi, Filippo E. 1 Lizak, Martin J. 1 Sato, Sanai 1 Kador, Peter F. 1; Affiliation:  1: Laboratory of Ocular Therapeutics, National Eye Insititute, National Institutes of Health, USA, Maryland, Bethesda, 10 Center Drive, MSC 1850, MD 20892-1850; Source Info: Apr99, Vol. 18 Issue 4, p277; Subject Term: ALDOSE reductase; Subject Term: POLYOLS; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: EPITHELIAL cells; Subject Term: CATARACT; Subject Term: DIAGNOSIS; Author-Supplied Keyword: aldose reductase; Author-Supplied Keyword: dog; Author-Supplied Keyword: lens; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Modesti, Mauro
AU  - Hesse, Joanne E.
AU  - Gellert, Martin
T1  - DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/04//4/1/99
VL  - 18
IS  - 7
M3  - Article
SP  - 2008
EP  - 2018
SN  - 02614189
AB  - Mammalian cells are protected from the effects of DNA double-strand breaks by end-joining repair. Cells lacking the Xrcc4 protein are hypersensitive to agents that induce DNA double-strand breaks, and are unable to complete V(D)J recombination. The residual repair of broken DNA ends in XRCC4-deficient cells requires short sequence homologies, thus possibly implicating Xrcc4 in end alignment. We show that Xrcc4 binds DNA, and prefers DNA with nicks or broken ends. Xrcc4 also binds to DNA ligase IV and enhances its joining activity. This stimulatory effect is shown to occur at the adenylation of the enzyme. DNA binding of Xrcc4 is correlated with its complementation of the V(D)J recombination defects in XRCC4-deficient cells, but is not required for stimulation of DNA ligase IV. Thus, the ability of Xrcc4 to bind to DNA suggests functions independent of DNA ligase IV. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DNA
KW  - NUCLEOTIDE sequence
KW  - PROTEINS
KW  - PROTEINS -- Research
KW  - NUCLEOTIDES
KW  - NUCLEOTIDE separation
KW  - dna ligase iv
KW  - end joining
KW  - v(d)j recombination
KW  - xrcc4
N1  - Accession Number: 13003954; Modesti, Mauro 1 Hesse, Joanne E. 1 Gellert, Martin 1; Email Address: gellert@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0540, USA; Source Info: 4/1/99, Vol. 18 Issue 7, p2008; Subject Term: DNA; Subject Term: NUCLEOTIDE sequence; Subject Term: PROTEINS; Subject Term: PROTEINS -- Research; Subject Term: NUCLEOTIDES; Subject Term: NUCLEOTIDE separation; Author-Supplied Keyword: dna ligase iv; Author-Supplied Keyword: end joining; Author-Supplied Keyword: v(d)j recombination; Author-Supplied Keyword: xrcc4; Number of Pages: 11p; Document Type: Article
L3  - 10.1093/emboj/18.7.2008
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107203713
T1  - Prevalence and impact of caregiving: a detailed comparison between dementia and nondementia caregivers.
AU  - Ory MG
AU  - Hoffman RR III
AU  - Yee JL
AU  - Tennstedt S
AU  - Schulz R
Y1  - 1999/04//
N1  - Accession Number: 107203713. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Instrumental Activities of Daily Living Scale (IADL). NLM UID: 0375327. 
KW  - Family -- Psychosocial Factors
KW  - Dementia -- Nursing
KW  - Economic Aspects of Illness
KW  - Caregivers
KW  - Activities of Daily Living
KW  - United States
KW  - Time Factors
KW  - Multiple Regression
KW  - Questionnaires
KW  - Surveys
KW  - Geriatric Assessment
KW  - Caregivers -- Psychosocial Factors
KW  - Workload
KW  - Descriptive Statistics
KW  - P-Value
KW  - Chi Square Test
KW  - T-Tests
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 177
EP  - 185
JO  - Gerontologist
JF  - Gerontologist
JA  - GERONTOLOGIST
VL  - 39
IS  - 2
PB  - Oxford University Press / USA
SN  - 0016-9013
AD  - BSR/NIA/NIH, Gateway Guilding Suite 553,, 7201 Wisconsin Ave. Msc 9205, Bethesda, MD 20892-9205; e-mail: marcia_ory@nih.gov
U2  - PMID: 10224714.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89445625
T1  - Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group.
AU  - Cheson, Bruce D.
AU  - Horning, Sandra J.
AU  - Coiffier, Bertrand
AU  - Shipp, Margaret A.
AU  - Fisher, Richard I.
AU  - Connors, Joseph M.
AU  - Lister, T. Andrew
AU  - Vose, Julie
AU  - Grillo-López, Antonio
AU  - Hagenbeek, Anton
AU  - Cabanillas, Fernando
AU  - Klippensten, Donald
AU  - Hiddemann, Wolfgang
AU  - Castellino, Ronald
AU  - Harris, Nancy L.
AU  - Armitage, James O.
AU  - Carter, William
AU  - Hoppe, Richard
AU  - Canellos, George P.
AU  - Cheson, B D
Y1  - 1999/04//4/1/1999
N1  - Accession Number: 89445625. Language: English. Entry Date: 19990601. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins); Schedules for Clinical Assessment in Neuropsychiatry (SCAN). NLM UID: 8309333. 
KW  - Clinical Trials -- Standards
KW  - Lymphoma, Non-Hodgkin's -- Therapy
KW  - Treatment Outcomes
KW  - Human
KW  - Lymphoma, Non-Hodgkin's -- Pathology
KW  - Combined Modality Therapy
KW  - Scales
SP  - 1244
EP  - 1244
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 4
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Standardized guidelines for response assessment are needed to ensure comparability among clinical trials in non-Hodgkin's lymphomas (NHL). To achieve this, two meetings were convened among United States and international lymphoma experts representing medical hematology/oncology, radiology, radiation oncology, and pathology to review currently used response definitions and to develop a uniform set of criteria for assessing response in clinical trials. The criteria that were developed include anatomic definitions of response, with normal lymph node size after treatment of 1.5 cm in the longest transverse diameter by computer-assisted tomography scan. A designation of complete response/unconfirmed was adopted to include patients with a greater than 75% reduction in tumor size after therapy but with a residual mass, to include patients-especially those with large-cell NHL-who may not have residual disease. Single-photon emission computed tomography gallium scans are encouraged as a valuable adjunct to assessment of patients with large-cell NHL, but such scans require appropriate expertise. Flow cytometric, cytogenetic, and molecular studies are not currently included in response definitions. Response rates may be the most important objective in phase II trials where the activity of a new agent is important and may provide support for approval by regulatory agencies. However, the goals of most phase III trials are to identify therapies that will prolong the progression-free survival, if not the overall survival, of the treated patients. We hope that these guidelines will serve to improve communication among investigators and comparability among clinical trials until clinically relevant laboratory and imaging studies are identified and become more widely available.
SN  - 0732-183X
AD  - National Cancer Institute, Bethesda, MD
AD  - Stanford University, Palo Alto, CA
AD  - Centre Hospitalier Lyon-Sud, Lyon, France
AD  - Dana-Farber Cancer Institute, Boston, MA
AD  - Loyola University, Maywood, IL
AD  - British Columbia Cancer Agency, Vancouver, British Columbia, Canada
AD  - St. Bartholomew's Hospital, London, England
AD  - University of Nebraska, Omaha, NE
AD  - IDEC Corporation, San Diego, CA
AD  - Universiteit Utrecht, Utrecht, the Netherlands
AD  - M.D. Anderson Cancer Center, Houston, TX
AD  - Roswell Park Cancer Institute, Buffalo, NY
AD  - Klinikum Großhadern, Munich, Germany
AD  - Memorial Sloan-Kettering Cancer Center, New York, NY
AD  - Massachusetts General Hospital, Boston, MA
AD  - Sharp Memorial Hospital, San Diego, CA
AD  - National Cancer Institute, Bethesda, MD 20892, USA
U2  - PMID: 10561185.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Mason, R. Preston
AU  - Leeds, Peter R.
AU  - Jacob, Robert F.
AU  - Hough, Christopher J.
AU  - Zhang, Kai-Gao
AU  - Mason, Pamela E.
AU  - Chuang, De-Maw
T1  - Inhibition of Excessive Neuronal Apoptosis by the Calcium Antagonist Amlodipine and Antioxidants in Cerebellar Granule Cells.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/04//
VL  - 72
IS  - 4
M3  - Article
SP  - 1448
EP  - 1456
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Neuronal cell death as a result of apoptosis is associated with cerebrovascular stroke and various neurodegenerative disorders. Pharmacological agents that maintain normal intracellular Ca2+ levels and inhibit cellular oxidative stress may be effective in blocking abnormal neuronal apoptosis. In this study, a spontaneous (also referred to as age-induced) model of apoptosis consisting of rat cerebellar granule cells was used to evaluate the antiapoptotic activities of voltage-sensitive Ca2+ channel blockers and various antioxidants. The results of these experiments demonstrated that the charged, dihydropyridine Ca2+ channel blocker amlodipine had very potent neuroprotective activity in this system, compared with antioxidants and neutral Ca2+ channel blockers (nifedipine and nimodipine). Within its effective pharmacological range (10-100 nM), amlodipine attenuated intracellular neuronal Ca2+ increases elicited by KCl depolarization but did not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibited free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. In parallel experiments, spontaneous neuronal apoptosis was inhibited in dose- and time-dependent manners by antioxidants (U-78439G, α-tocopherol, and melatonin), nitric oxide synthase inhibitors (N-nitro-L-arginine and N-nitro-D-arginine), and a nitric oxide chelator (hemoglobin) in the micromolar range. These results suggest that spontaneous neuronal apoptosis is associated with excessive Ca2+ influx, leading to further intracellular Ca2+ increases and the generation of reactive oxygen species. Agents such as amlodipine that block voltage-sensitive Ca2+ channels and inhibit cellular oxidative stress may be effective in the treatment of cerebrovascular stroke and neurodegenerative diseases associated with excessive apoptosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CALCIUM antagonists
KW  - ANTIOXIDANTS
KW  - Antioxidants
KW  - Apoptosis
KW  - Ca
KW  - Cerebellar granule cells
N1  - Accession Number: 5635541; Mason, R. Preston Leeds, Peter R. 1 Jacob, Robert F. Hough, Christopher J. 1 Zhang, Kai-Gao 1 Mason, Pamela E. Chuang, De-Maw 1; Affiliation:  1: Section on Molecular Neurobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr99, Vol. 72 Issue 4, p1448; Subject Term: CALCIUM antagonists; Subject Term: ANTIOXIDANTS; Author-Supplied Keyword: Antioxidants; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Ca; Author-Supplied Keyword: Cerebellar granule cells; Number of Pages: 9p; Illustrations: 2 Black and White Photographs, 8 Graphs; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.721448.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Christie, J. M.
AU  - Wenthold, R. J.
AU  - Monaghan, D. T.
T1  - Insulin Causes a Transient Tyrosine Phosphorylation of NR2A and NR2B NMDA Receptor Subunits in Rat Hippocampus.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/04//
VL  - 72
IS  - 4
M3  - Article
SP  - 1523
EP  - 1528
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Abstract: NMDA receptors play a critical role in various aspects of CNS function. Hence, it is important to identify mechanisms that regulate NMDA receptor activity. We have shown previously that insulin rapidly potentiates NMDA receptor activity in both native and recombinant expression systems. Here we report that insulin causes a transient phosphorylation of NR2A and NR2B NMDA receptor subunits on tyrosine residues. Rat hippocampal slices were exposed to 1 μM insulin for 20 and 60 min and then solubilized. NR2A and NR2B subunits were immunoprecipitated and probed for tyrosine phosphorylation. Insulin incubation of hippocampal slices for 20 min elicited an increase in tyrosine phosphorylation to 176 ± 16% (NR2A) and 203 ± 15% (NR2B) of control levels. In contrast, 60 min of insulin incubation did not alter NR2 tyrosine phosphorylation levels (NR2A: 85 ± 13% of control; NR2B: 93 ± 10% of control). Although the consequence of insulin-stimulated tyrosine phosphorylation is unknown, it is possible that this site(s) is responsible for insulin potentiation of NMDA receptor activity. This possibility is consistent with our earlier finding that insulin potentiates hippocampal NMDA receptor activity after 20 min, but not after 60 min, of insulin exposure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INSULIN
KW  - PHOSPHORYLATION
KW  - NEURAL receptors
KW  - HIPPOCAMPUS (Brain)
KW  - PHYSIOLOGY
KW  - Growth factor
KW  - Hippocampus
KW  - Insulin
KW  - Kinase
KW  - N-methyl-d-aspartate
KW  - Phosphorylation
N1  - Accession Number: 5635532; Christie, J. M. Wenthold, R. J. 1 Monaghan, D. T.; Affiliation:  1: Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr99, Vol. 72 Issue 4, p1523; Subject Term: INSULIN; Subject Term: PHOSPHORYLATION; Subject Term: NEURAL receptors; Subject Term: HIPPOCAMPUS (Brain); Subject Term: PHYSIOLOGY; Author-Supplied Keyword: Growth factor; Author-Supplied Keyword: Hippocampus; Author-Supplied Keyword: Insulin; Author-Supplied Keyword: Kinase; Author-Supplied Keyword: N-methyl-d-aspartate; Author-Supplied Keyword: Phosphorylation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Illustrations: 3 Black and White Photographs, 2 Graphs; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.721523.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107208259
T1  - Toward a common theme for autoimmunity.
AU  - Slavkin HC
Y1  - 1999/04//
N1  - Accession Number: 107208259. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Autoimmune Diseases
KW  - Autoimmune Diseases -- Epidemiology
KW  - Autoimmune Diseases -- Familial and Genetic
KW  - Autoimmune Diseases -- Immunology
KW  - Diabetes Mellitus, Type 1 -- Immunology
KW  - Lupus Erythematosus, Systemic -- Immunology
KW  - Information Resources
KW  - Sex Factors
KW  - Male
KW  - Female
SP  - 561
EP  - 566
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 103
IS  - 4
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, MD 20892-2290
U2  - PMID: 10203908.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107208259&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Borlongan, Cesario V
AU  - Sanberg, Paul R
AU  - Freeman, Thomas B
T1  - Neural transplantation for neurodegenerative disorders.
JO  - Lancet
JF  - Lancet
Y1  - 1999/04//Apr1999 Supplement 1
VL  - 353
M3  - Article
SP  - SI29
EP  - SI30
PB  - Lancet
SN  - 00995355
AB  - This article focuses on neural transplantation for neurodegenerative disorders. Parkinson's disease (PD) was the first neurodegenerative disorder to be treated with transplant techniques because symptoms are secondary to the loss of a limited number of nigrostriatal dopaminergic neurons. Several clinical centres have reported preliminary data that transplantation of fetal tissue is beneficial for some PD patients, with some centres obtaining more reproducible results than others. To date, more than 300 PD patients world wide have received neural transplants of embryonic ventral essence tissue. Of these patients, three have died because of the surgery, and 11 from causes unrelated to the procedure. Clinical trials of transplantation of fetal neural tissue were pioneered a researcher in Sweden. Subsequent trials of unilateral intrastriatal transplants by these investigators showed graft-derived improvements on fluorodopa positron-emission tomography and in rigidity, hypokinesia, dyskinesia, and the percentage of time in the off state for up to 4 years.
KW  - NEURODEGENERATION
KW  - PARKINSON'S disease
KW  - BRAIN diseases
KW  - NEURONS
KW  - CLINICAL trials
KW  - NERVE tissue
KW  - PATIENTS
KW  - EMISSION tomography
KW  - MOVEMENT disorders
N1  - Accession Number: 20444728; Borlongan, Cesario V 1 Sanberg, Paul R 2 Freeman, Thomas B 2; Affiliation:  1: Cellular Neurobilogy Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA  2: Department of Neurological surgery, Department of Pharmacology and Experimental TTherapeutics, University South Florida College of Medicine, Tampa, FL, USA; Source Info: Apr1999 Supplement 1, Vol. 353, pSI29; Subject Term: NEURODEGENERATION; Subject Term: PARKINSON'S disease; Subject Term: BRAIN diseases; Subject Term: NEURONS; Subject Term: CLINICAL trials; Subject Term: NERVE tissue; Subject Term: PATIENTS; Subject Term: EMISSION tomography; Subject Term: MOVEMENT disorders; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 2p; Illustrations: 1 Black and White Photograph; Document Type: Article; Full Text Word Count: 1264
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20444728&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107207690
T1  - Occupational physical activity and non-Hodgkin's lymphoma.
AU  - Zahm SH
AU  - Hoffman-Goetz L
AU  - Dosemeci M
AU  - Cantor KP
AU  - Blair A
Y1  - 1999/04//1999 Apr
N1  - Accession Number: 107207690. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8005433. 
KW  - Physical Activity
KW  - Work
KW  - Lymphoma, Non-Hodgkin's
KW  - Registries, Disease
KW  - Iowa
KW  - Minnesota
KW  - Kansas
KW  - Nebraska
KW  - Farmworkers
KW  - Energy Metabolism -- Evaluation
KW  - Scales
KW  - Age Factors
KW  - Case Control Studies
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Mantel-Haenszel Test
KW  - Epidemiological Research
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 566
EP  - 571
JO  - Medicine & Science in Sports & Exercise
JF  - Medicine & Science in Sports & Exercise
JA  - MED SCI SPORTS EXERC
VL  - 31
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - PURPOSE: The purpose of this study was to evaluate the role of physical activity in the development of non-Hodgkin's lymphoma (NHL). METHODS: Incident NHL cases and population-based controls were identified from three case-control studies conducted in four midwestern states: Iowa, Kansas, Minnesota, and Nebraska. A total of 1177 cases (993 men, 184 women) and 3625 controls (2918 men, 707 women) were interviewed. Usual occupation (all states) and lifetime occupational histories (Iowa and Minnesota only), obtained from interviews, were classified for energy expenditure (EE) and sitting time. Odds ratios (OR) and 95% confidence intervals were calculated comparing moderate and high activity levels with sedentary levels. RESULTS: There was no evidence of an association between NHL and occupational physical activity measured either by EE or sitting time. Among men, the OR associated with usual occupation moderate and high EE were 1.1 and 1.0, respectively. For sitting time, the OR were also 1.1 and 1.0 for moderate and high activity, respectively. Among women, slight nonsignificant elevations in risk of NHL were observed among the high energy level and high activity sitting categories. The trends were not significant. There was no evidence of confounding or effect modification by vital status, hair dye use, or solvent exposure. Among subjects with lifetime occupational histories, there were no significant increases or trends for cumulative or average EE or sitting time. There was no association between occupational physical activity and NHL. CONCLUSION: Research on nonoccupational physical activity, which in the U.S. is likely the more important component of daily activity than occupational activity, may still be warranted given the laboratory evidence linking physical activity and immune function, an important factor in the etiology of NHL.
SN  - 0195-9131
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD
U2  - PMID: 10211853.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107207690&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Remaley, Alan T.
AU  - Woods, Joseph J.
AU  - Glickman, Janice W.
T1  - Point-of-care testing of parathyroid hormone during the surgical treatment of hyperparathyroidism. (Cover story)
JO  - MLO: Medical Laboratory Observer
JF  - MLO: Medical Laboratory Observer
Y1  - 1999/04//
VL  - 31
IS  - 4
M3  - Article
SP  - 21
EP  - 27
SN  - 05807247
AB  - Evaluates the effectiveness of the developed point-of-care test for parathyroid hormone (PTH), dubbed as the QuiCk-IntraOperative Intact PTH Assay, during the surgical treatment of hyperparathyroidism in the U.S.  Utilization of the point-of-care test; Advantages presented by the developed test in the surgical management of the patients; Relationships between the biochemistry of calcium metabolism and the pathophysiology of hyperparathroidism.
KW  - POINT-of-care testing
KW  - MEDICAL laboratories -- Equipment & supplies
KW  - HYPERPARATHYROIDISM
KW  - THYROID gland -- Surgery
KW  - PARATHYROID hormone
KW  - RESEARCH
KW  - MEDICAL technology
KW  - UNITED States
N1  - Accession Number: 11740083; Remaley, Alan T. 1 Woods, Joseph J. 1 Glickman, Janice W. 1; Affiliation:  1: National Institutes of Health, Clinical Center, Clinical Pathology Department, Bethesda, MD; Source Info: Apr99, Vol. 31 Issue 4, p21; Subject Term: POINT-of-care testing; Subject Term: MEDICAL laboratories -- Equipment & supplies; Subject Term: HYPERPARATHYROIDISM; Subject Term: THYROID gland -- Surgery; Subject Term: PARATHYROID hormone; Subject Term: RESEARCH; Subject Term: MEDICAL technology; Subject Term: UNITED States; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11740083&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107202725
T1  - Point-of-care testing of parathyroid hormone during the surgical treatment of hyperparathyroidism.
AU  - Remaley AT
AU  - Woods JJ
AU  - Glickman JW
Y1  - 1999/04//
N1  - Accession Number: 107202725. Language: English. Entry Date: 19990801. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0225602. 
KW  - Hyperparathyroidism -- Surgery
KW  - Point-of-Care Testing
KW  - Parathyroid Hormones -- Analysis
KW  - Intraoperative Monitoring
KW  - Calcium -- Metabolism
KW  - Hyperparathyroidism -- Physiopathology
KW  - Monitoring, Physiologic
KW  - Hyperparathyroidism -- Therapy
KW  - Education, Continuing (Credit)
SP  - 20
EP  - 28
JO  - MLO: Medical Laboratory Observer
JF  - MLO: Medical Laboratory Observer
JA  - MLO
VL  - 31
IS  - 4
CY  - Sarasota, Florida
PB  - NP Communications, LLC
SN  - 0580-7247
AD  - Senior Staff, National Institutes of Health, Clinical Center, Clinical Pathology Dept, Bethesda, MD
U2  - PMID: 10387252.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107202725&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107191754
T1  - Breast cancer screening and African American women: fear, fatalism, and silence.
AU  - Phillips JM
AU  - Cohen MZ
AU  - Moses G
Y1  - 1999/04//1999 Apr
N1  - Accession Number: 107191754. Language: English. Entry Date: 19990601. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Grant Information: Supported by an intramural grant from the University of Maryland School of Nursing. NLM UID: 7809033. 
KW  - Blacks
KW  - Breast Neoplasms -- Diagnosis
KW  - Health Beliefs
KW  - Cancer Screening
KW  - Attitude to Illness
KW  - Attitude to Illness -- Evaluation
KW  - Funding Source
KW  - Qualitative Studies
KW  - Focus Groups
KW  - Urban Areas -- Maryland
KW  - Socioeconomic Factors
KW  - Sampling Methods
KW  - Maryland
KW  - Audiorecording
KW  - Thematic Analysis
KW  - Health Beliefs -- Evaluation
KW  - Adult
KW  - Middle Age
KW  - Female
KW  - Descriptive Statistics
KW  - Fear
KW  - Human
SP  - 561
EP  - 571
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 26
IS  - 3
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - PURPOSE/OBJECTIVES: To explore the beliefs, attitudes, and practices related to breast cancer and breast cancer screening among low- and middle-income African American women. DESIGN: Qualitative study using focus group methodology. SAMPLE/SETTING: 26 African American women, age 40-65, selected from three employment groups, recruited from a community-based center and a local teacher's union in a moderate-sized urban area. METHODS: Three 90-minute focus group discussions exploring breast cancer beliefs, attitudes, and practices were audiotaped, transcribed verbatim, and analyzed using thematic context analysis techniques. FINDINGS: When breast cancer was discussed, fear was the predominant feeling expressed in all groups. This fear was a primary reason not to engage in breast cancer screening. Unemployed women and service workers emphasized the role of violence in causing breast cancer, whereas teachers discussed injury and sex as causing breast cancer. All participants stressed that breast cancer is seldom discussed within the African American community. Teachers added that this secrecy within the African American community leads to breast cancer being viewed as a white woman's disease. CONCLUSIONS: Despite initiatives promoting breast cancer awareness, African American women still hold misconceptions regarding the etiology of breast cancer and fatalistic perspectives regarding breast cancer outcomes, perhaps because breast cancer is discussed infrequently. Because pain, fear, and fatalism were discussed in all groups, future research should address the influence of these factors to increase screening behaviors. IMPLICATIONS FOR NURSING PRACTICE: Because unemployed women, service workers, and teachers differed in their beliefs about breast cancer and breast cancer screening, nurses must be mindful of the need to tailor interventions to address the needs of both low- and middle-income African American women.
SN  - 0190-535X
AD  - National Institute of Nursing Research, Bethesda, MD
U2  - PMID: 10214597.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107191754&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107198002
T1  - Bilateral condylar resorption in dermatomyositis: a case report.
AU  - Brennan MT
AU  - Patronas NJ
AU  - Brahim JS
Y1  - 1999/04//1999 Apr
N1  - Accession Number: 107198002. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images; pictorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101576782. 
KW  - Bone Resorption -- Etiology
KW  - Dermatomyositis -- Complications
KW  - Malocclusion -- Etiology
KW  - Mandibular Condyle -- Physiopathology
KW  - Temporomandibular Joint Diseases -- Etiology
KW  - Male
KW  - Adult
KW  - Malocclusion -- Surgery
KW  - Osteotomy
KW  - Range of Motion
SP  - 446
EP  - 451
JO  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JF  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JA  - ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDO
VL  - 87
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
AB  - Polymyositis is an inflammatory disease commonly affecting the striated muscle. When it is accompanied by characteristic skin lesions, the condition is called dermatomyositis. Bilateral condylar resorption has been reported with autoimmune conditions and chronic systemic steroids. We report the first documented case of bilateral condylar resorption in a patient with dermatomyositis. Possible etiologic factors and treatment outcomes are discussed.
SN  - 1079-2104
AD  - Gene Therapy and Therapeutics Branch, National Institute of Dental Research, National Institutes of Health
U2  - PMID: 10225627.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107198002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - CONF
AU  - Cohen, Mitchell D.
AU  - Schook, Lawrence B.
AU  - Oppenheim, Joost J.
AU  - Freed, Brian M.
AU  - Rodgers, Kathleen E.
T1  - Forum. Symposium overview: alterations in cytokine receptors by xenobiotics.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/04//
VL  - 48
IS  - 2
M3  - Proceeding
SP  - 163
EP  - 169
PB  - Oxford University Press / USA
SN  - 10966080
AB  - A symposium entitled Alterations in Cytokine Receptors by Xenobiotics was held at the 37th Annual Meeting of the Society of Toxicology (SOT) in Seattle, Washington. The symposium was sponsored by the Immunotoxicology Specialty Section of SOT and was designed to present information on the effect of several difference classes of xenobiotics on various aspects of receptor function (i.e., post-receptor signal transduction of receptor expression), or the involvement of cytokine receptors in the action of the toxicant under consideration. This symposium brought together scientists in the area of receptor immunobiology whose expertise in receptor modulation encompassed those major signaling agents involved in the normal immune response, i.e., proinflammatory cytokines, chemokines, interleukins, and interferons. The following is a summary of each of the individual presentations. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Conferences & conventions
KW  - Cytokines -- Congresses
KW  - Xenobiotics -- Congresses
KW  - Toxicology -- Congresses
KW  - Seattle (Wash.)
KW  - Washington (State)
N1  - Accession Number: 44405738; Cohen, Mitchell D. 1; Schook, Lawrence B. 2; Oppenheim, Joost J. 3; Freed, Brian M. 4; Rodgers, Kathleen E. 5; Affiliations: 1: Department of Environmental Medicine, New York University Medical Center, 57 Old Forge Road, Tuxedo, New York, 10987; 2: Food Animal Biotechnology Center, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108; 3: Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland 21702; 4: Department of Medicine, University of Colorado Health Science Center, Denver, Colorado 80262; 5: Livingston Research Institute, University of Southern California, Los Angeles, California 90033; Issue Info: Apr1999, Vol. 48 Issue 2, p163; Subject Term: Conferences & conventions; Subject Term: Cytokines -- Congresses; Subject Term: Xenobiotics -- Congresses; Subject Term: Toxicology -- Congresses; Subject: Seattle (Wash.); Subject: Washington (State); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Proceeding
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2011-11023-008
AN  - 2011-11023-008
AU  - Asthana, Sanjay
AU  - Raffaele, Kathleen C.
AU  - Greig, Nigel H.
AU  - Schapiro, Mark B.
AU  - Blackman, Marc R.
AU  - Soncrant, Timothy T.
T1  - Neuroendocrine responses to intravenous infusion of physostigmine in patients with Alzheimer disease.
JF  - Alzheimer Disease and Associated Disorders
JO  - Alzheimer Disease and Associated Disorders
JA  - Alzheimer Dis Assoc Disord
Y1  - 1999/04//Apr-Jun, 1999
VL  - 13
IS  - 2
SP  - 102
EP  - 108
CY  - US
PB  - Lippincott Williams & Wilkins
SN  - 0893-0341
AD  - Asthana, Sanjay, GRECC, VA Puget Sound Health Care System, American Lake Division, (182 B), Tacoma, WA, US, 98493
N1  - Accession Number: 2011-11023-008. PMID: 10372954 Partial author list: First Author & Affiliation: Asthana, Sanjay; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20110919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual meeting of the American Geriatrics Society, Nov, 1993, New Orleans, LA, US. Conference Note: Preliminary results of this study were presented at the aforementioned conference. Major Descriptor: Alzheimer's Disease; Drug Therapy; Hormones; Memory; Physostigmine. Minor Descriptor: Drug Dosages; Hypothalamic Pituitary Adrenal Axis; Intravenous Injections; Neuroendocrinology. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Mini Mental State Examination. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr-Jun, 1999. Publication History: Accepted Date: Aug 17, 1998; Revised Date: Feb 19, 1998; First Submitted Date: Apr 8, 1997. Copyright Statement: Lippincott Williams & Wilkins, Inc. 1999. 
AB  - We have reported that physostigmine, a reversible cholinesterase inhibitor, enhances verbal memory in patients with Alzheimer disease (AD). To elucidate the mechanism of cognition enhancement, plasma hormones were measured during high-dose acute and low-dose chronic steady-state intravenous infusions of physostigmine in nine subjects with AD. High-dose hormone responses were measured during and for 24 h after the infusion of physostigmine 1-1.5 mg over 45-60 min. Chronic responses were measured during continuous intravenous infusions of physostigmine at doses (0.5-25 mg/day) that escalated over 2 weeks, and then during 1 week infusion of the dose that optimized cognition (2-12 mg/day) or placebo administered in a randomized, double-blind, crossover design. A replicable improvement in verbal memory was found in five subjects. High-dose physostigmine infusion that produced noxious side effects resulted in significant elevation above baseline in plasma levels of adrenocorticotrophic hormone (ACTH) (p = 0.0001), Cortisol (p = 0.0001), and β-endorphin (p = 0.0001). Chronic physostigmine administration, in the absence of adverse effects, produced no significant elevation in ACTH (p = 0.08), Cortisol (p = 0.70), or β-endorphin (p = 0.82). These results indicate that high-dose physostigmine activates the hypothalamic-pituitary-adrenal (HPA) axis, likely representing a 'stress response.' In contrast, cognition-enhancing doses do not produce a peripheral corticosteroid response. Thus, physostigmine-induced memory improvement is independent of the activation of the HPA axis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug therapy
KW  - memory enhancement
KW  - physostigmine
KW  - cholinesterase inhibitors
KW  - Alzheimer's disease
KW  - intravenous infusion
KW  - drug dosages
KW  - neuroendocrine responses
KW  - hormones
KW  - hypothalamic pituitary adrenal axis
KW  - 1999
KW  - Alzheimer's Disease
KW  - Drug Therapy
KW  - Hormones
KW  - Memory
KW  - Physostigmine
KW  - Drug Dosages
KW  - Hypothalamic Pituitary Adrenal Axis
KW  - Intravenous Injections
KW  - Neuroendocrinology
KW  - 1999
DO  - 10.1097/00002093-199904000-00008
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-11023-008&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-00289-003
AN  - 2006-00289-003
AU  - Murray, Elisabeth A.
AU  - Bussey, Timothy J.
T1  - Perceptual-mnemonic of the perirhinal cortex.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1999/04//
VL  - 3
IS  - 4
SP  - 142
EP  - 151
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Murray, Elisabeth A., Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B80, Bethesda, MD, US, 20892-4415
N1  - Accession Number: 2006-00289-003. PMID: 10322468 Partial author list: First Author & Affiliation: Murray, Elisabeth A.; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Memory; Mnemonic Learning; Perception; Temporal Lobe. Minor Descriptor: Monkeys; Neuroanatomy; Neuropsychology. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). Methodology: Literature Review. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 1999. 
AB  - It is widely acknowledged that the perirhinal cortex, located in the ventromedial aspect of the temporal lobe, is essential for certain types of memory in macaque monkeys. For example, removal of the perirhinal cortex yields severe impairments on tests of stimulus recognition and stimulus-stimulus association. There is considerable disagreement, however, about the most accurate way to characterize the function of the perirhinal cortex; some views emphasize a role in perception whereas others posit a role exclusively in declarative memory. In this article, we review recent findings from anatomical, physiological and ablation studies in monkeys, and discuss related findings obtained in humans, in an attempt to identify not only the cognitive functions of the perirhinal cortex, but also the implications of these findings for theoretical views concerning the organization of memory. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - perceptual mnemonic
KW  - perirhinal cortex
KW  - macaque monkeys
KW  - humans
KW  - cognitive functions
KW  - memory
KW  - 1999
KW  - Cognitive Processes
KW  - Memory
KW  - Mnemonic Learning
KW  - Perception
KW  - Temporal Lobe
KW  - Monkeys
KW  - Neuroanatomy
KW  - Neuropsychology
KW  - 1999
DO  - 10.1016/S1364-6613(99)01303-0
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00289-003&site=ehost-live&scope=site
UR  - 
UR  - ORCID: 0000-0003-1450-1642
UR  - bussey@ln.nimh.nih.gov
UR  - eam@ln.nimh.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Makuc, Diane M.
AU  - Breen, Nancy
AU  - Freid, Virginia
AD  - National Center for Health Statistics/CDC
AD  - National Cancer Institute
AD  - National Center for Health Statistics/CDC
T1  - Low Income, Race, and the Use of Mammography
JO  - Health Services Research
JF  - Health Services Research
Y1  - 1999/04/02/
VL  - 34
IS  - 1
SP  - 229
EP  - 239
SN  - 00179124
N1  - Accession Number: 0492012; Keywords: Income;  Race; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199906
N2  - These results, which provide some evidence of success for screening programs targeted to the poor, raise the question of why low-income black women appear to be more likely than low-income white women to have benefited from recent efforts to promote mammography. Continued evaluation of mammography programs focused on women who are underserved as well as the monitoring of trends and variations in service use by race and income are needed.
KW  - Health Production          I12
KW  - Economics of Minorities, Races, Indigenous Peoples, and Immigrants; Non-labor Discrimination          J15
KW  - Personal Income, Wealth, and Their Distributions          D31
L3  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0492012&site=ehost-live&scope=site
UR  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Bies, J.
AU  - Nazarov, V.
AU  - Wolff, L.
T1  - Alteration of proteolytic processing of c-Myb as a consequence of its truncation in murine myeloid leukemia.
JO  - Leukemia (08876924)
JF  - Leukemia (08876924)
Y1  - 1999/04/02/Apr1999 Supplement 1
VL  - 13
M3  - Article
SP  - S116
EP  - S117
PB  - Nature Publishing Group
SN  - 08876924
AB  - The article presents information on a study which constructed a series of deletion mutants in an attempt to localize areas of the Carboxy-terminal portion of the protein that affect rates of degradation of the normal protein. These mutants were transiently expressed in COS 7 cells and analyzed in a pulse chase experiment. The study found that the constitutive turnover of c-Myb in myeloid cells is slowed down in the case of leukemia-specific truncated forms of the protein.
KW  - MUTATION (Biology)
KW  - LEUKEMIA
KW  - PROTEINS
KW  - ANEMIA
KW  - LEUCOCYTOSIS
KW  - CANCER
N1  - Accession Number: 23264456; Bies, J. 1,2 Nazarov, V. 1 Wolff, L. 1; Affiliation:  1: Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA.  2: Cancer Research Institute, SAS, Slovakia.; Source Info: Apr1999 Supplement 1, Vol. 13, pS116; Subject Term: MUTATION (Biology); Subject Term: LEUKEMIA; Subject Term: PROTEINS; Subject Term: ANEMIA; Subject Term: LEUCOCYTOSIS; Subject Term: CANCER; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107205451
T1  - Diabetes and decline in heart disease mortality in US adults.
AU  - Gu K
AU  - Cowie CC
AU  - Harris MI
AU  - Gu, K
AU  - Cowie, C C
AU  - Harris, M I
Y1  - 1999/04/14/
N1  - Accession Number: 107205451. Language: English. Entry Date: 19990801. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Poothullil J M. Diabetes and decline in heart disease mortality. (JAMA) 9/22/99; 282 (12): 1132-1132. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Diabetes Mellitus -- Complications
KW  - Coronary Disease -- Mortality -- United States
KW  - United States
KW  - Retrospective Design
KW  - Confidence Intervals
KW  - P-Value
KW  - Prospective Studies
KW  - Cardiovascular Risk Factors
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 1291
EP  - 1297
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 281
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Context: Mortality from coronary heart disease has declined substantially in the United States during the past 30 years. However, it is unknown whether patients with diabetes have also experienced a decline in heart disease mortality.Objective: To compare adults with diabetes with those without diabetes for time trends in mortality from all causes, heart disease, and ischemic heart disease.Design, Setting, and Participants: Representative cohorts of subjects with and without diabetes were derived from the First National Health and Nutrition Examination Survey (NHANES I) conducted between 1971 and 1975 (n = 9639) and the NHANES I Epidemiologic Follow-up Survey conducted between 1982 and 1984 (n = 8463). The cohorts were followed up prospectively for mortality for an average of 8 to 9 years.Main Outcome Measure: Changes in mortality rates per 1000 person-years for all causes, heart disease, and ischemic heart disease for the 1982-1984 cohort compared with the 1971-1975 cohort.Results: For the 2 periods, nondiabetic men experienced a 36.4% decline in age-adjusted heart disease mortality compared with a 13.1% decline for diabetic men. Age-adjusted heart disease mortality declined 27% in nondiabetic women but increased 23% in diabetic women. These patterns were also found for all-cause mortality and ischemic heart disease mortality.Conclusions: The decline in heart disease mortality in the general US population has been attributed to reduction in cardiovascular risk factors and improvement in treatment of heart disease. The smaller declines in mortality for diabetic subjects in the present study indicate that these changes may have been less effective for people with diabetes, particularly women.
SN  - 0098-7484
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md
U2  - PMID: 10208144.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Eisenhofer, Graeme
AU  - Coughtrie, Michael Wh
AU  - Goldstein, David S
T1  - DOPAMINE SULPHATE: AN ENIGMA RESOLVED.
JO  - Clinical & Experimental Pharmacology & Physiology
JF  - Clinical & Experimental Pharmacology & Physiology
Y1  - 1999/04/15/Apr99 Supplement 1
VL  - 26
M3  - Article
SP  - S41
EP  - S53
PB  - Wiley-Blackwell
SN  - 03051870
AB  - 1. The source and physiological significance of dopamine (DA) sulphate, which exists in plasma at much higher concentrations than free DA, have long been a puzzle. The present article reviews how the convergence of modern molecular and traditional clinical approaches is shedding new light on the origins and meaning of DA sulphate. 2. The sulphotransferase isoenzyme responsible for production of DA sulphate in humans (SULT1A3) has been cloned and shown to be expressed in large quantities in the gastrointestinal tract, but not in liver. No orthologue of SULT1A3 has yet been identified in other species, consistent with the greater importance of sulphate conjugation of DA in humans than in most animals. 3. Diet has a major impact on plasma DA sulphate, with dramatic increases after ingestion of meals and foods rich in biogenic amines; however, substantial amounts of DA sulphate remaining after prolonged fasting indicate the presence of a mainly endogenous source. The lack of influence of acute or chronic changes in sympathetic outflow or of sympathoneural degeneration on plasma DA sulphate indicates that DA sulphate does not derive from sympathetic nerve. Relatively low rates of production from intravenously infused DA indicate that very little DA sulphate (< 2%) derives from metabolism of circulating DA, such as in red cells or platelets. 4. Consistent increments in DA sulphate from arterial to the outflowing venous plasma draining mesenteric organs, without increments across other organs or tissues (e.g. heart, lungs, liver), indicate that the gastrointestinal tract is a major source of more than 75% of DA sulphate produced in the body. The gastrointestinal tract is also the site of a novel DA autocrine/paracrine system that produces nearly 50% of the DA in the body. Therefore, production of DA sulphate appears to reflect an enzymatic ‘gut–blood’ barrier for detoxifying dietary biogenic amines and delimiting autocrine/ paracrine effects of... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical & Experimental Pharmacology & Physiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DOPAMINE
KW  - SULFATES
KW  - GASTROINTESTINAL system
KW  - SULFUR in the body
KW  - catecholamines
KW  - dopamine
KW  - gastrointestinal tract
KW  - liver
KW  - phenolsulphotransferase
N1  - Accession Number: 5507712; Eisenhofer, Graeme 1 Coughtrie, Michael Wh 2 Goldstein, David S 1; Affiliation:  1: Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA and  2: Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK; Source Info: Apr99 Supplement 1, Vol. 26, pS41; Subject Term: DOPAMINE; Subject Term: SULFATES; Subject Term: GASTROINTESTINAL system; Subject Term: SULFUR in the body; Author-Supplied Keyword: catecholamines; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: gastrointestinal tract; Author-Supplied Keyword: liver; Author-Supplied Keyword: phenolsulphotransferase; Number of Pages: 13p; Document Type: Article
L3  - 10.1046/j.1440-1681.1999.00027.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107205499
T1  - Criteria and recommendations for vitamin C intake.
AU  - Levine M
AU  - Rumsey SC
AU  - Daruwala R
AU  - Park JB
AU  - Wang Y
AU  - Levine, M
AU  - Rumsey, S C
AU  - Daruwala, R
AU  - Park, J B
AU  - Wang, Y
Y1  - 1999/04/21/
N1  - Accession Number: 107205499. Language: English. Entry Date: 19990801. Revision Date: 20161112. Publication Type: journal article; review; tables/charts. Commentary: Ordman A B. Recommendations for vitamin C intake. (JAMA) 12/8/99; 282 (22): 2118-2119. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Ascorbic Acid
SP  - 1415
EP  - 1423
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 281
IS  - 15
CY  - Chicago, Illinois
PB  - American Medical Association
AB  - Recommendations for vitamin C intake are under revision by the Food and Nutrition Board of the National Academy of Sciences. Since 1989 when the last recommended dietary allowance (RDA) of 60 mg was published, extensive biochemical, molecular, epidemiologic, and clinical data have become available. New recommendations can be based on the following 9 criteria: dietary availability, steady-state concentrations in plasma in relationship to dose, steady-state concentrations in tissues in relationship to dose, bioavailability, urine excretion, adverse effects, biochemical and molecular function in relationship to vitamin concentration, direct beneficial effects and epidemiologic observations in relationship to dose, and prevention of deficiency. We applied these criteria to the Food and Nutrition Board's new guidelines, the Dietary Reference Intakes, which include 4 reference values. The estimated average requirement (EAR) is the amount of nutrient estimated to meet the requirement of half the healthy individuals in a life-stage and gender group. Based on an EAR of 100 mg/d of vitamin C, the RDA is proposed to be 120 mg/d. If the EAR cannot be determined, an adequate intake (AI) amount is recommended instead of an RDA. The AI was estimated to be either 200 mg/d from 5 servings of fruits and vegetables or 100 mg/d of vitamin C to prevent deficiency with a margin of safety. The final classification, the tolerable upper intake level, is the highest daily level of nutrient intake that does not pose risk or adverse health effects to almost all individuals in the population. This amount is proposed to be less than 1 g of vitamin C daily. Physicians can tell patients that 5 servings of fruits and vegetables per day may be beneficial in preventing cancer and providing sufficient vitamin C intake for healthy people, and that 1 g or more of vitamin C may have adverse consequences in some people.
SN  - 0098-7484
AD  - Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
AD  - National Institutes of Health, Bldg 10, Rm 4D52, MSC1372, Bethesda, MD 20892
U2  - PMID: 10217058.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yih-Ing Hser
AU  - Joshi, Vandana
AU  - Anglin, M. Douglas
AU  - Fletcher, Bennett
T1  - Predicting Posttreatment Cocaine Abstinence for First-Time Admissions and Treatment Repeaters.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/05//
VL  - 89
IS  - 5
M3  - Article
SP  - 666
EP  - 671
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined client and program characteristics that predict posttreatment cocaine abstinence among cocaine abusers with different treatment histories. Methods. Cocaine abusers (n = 507) treated in 18 residential programs were interviewed at intake and 1-year follow- up as part of the nationwide Drug Abuse Treatment Outcome Study (DATOS). Program directors provided the program- level data in a mail survey. We applied the hierarchical linear modeling approach for the analysis. Results. No prior treatment and longer retention in DATOS programs were positive predictors of posttreatment abstinence. The interactive effect of these 2 variables was also significantly positive. Programs that offered legal services and included recovering staff increased their clients' likelihood of cocaine abstinence. Crack use at both the client and program level predicted negative impact. None of the program variables assessed differentially affected the outcomes of first- timers and repeaters. conclusions. Although treatment repeaters were relatively difficult to treat, their likelihood of achieving abstinence was similar to that of first- timers if they were retained in treatment for a sufficient time. First-timers and repeaters responded similarly to the treatment program characteristics examined. The treatment and policy implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - COCAINE abuse
KW  - DRUG abuse -- Treatment
KW  - DRUG addicts
KW  - DRUG abusers
KW  - DRUGS of abuse
KW  - SUBSTANCE abuse
N1  - Accession Number: 1804231; Yih-Ing Hser 1; Email Address: ysher@ucla.edu Joshi, Vandana 1 Anglin, M. Douglas 1 Fletcher, Bennett 2; Affiliation:  1: Neuropsychiatric Institute, University of California, Los Angeles  2: National Institute on Drug Abuse (NIDA), Bethesda, Md.; Source Info: May99, Vol. 89 Issue 5, p666; Subject Term: COCAINE abuse; Subject Term: DRUG abuse -- Treatment; Subject Term: DRUG addicts; Subject Term: DRUG abusers; Subject Term: DRUGS of abuse; Subject Term: SUBSTANCE abuse; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 6p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Svikis, Dace S.
AU  - Pickens, Roy W.
AU  - Schweitzer, Wendy
AU  - Johnson, Eric
AU  - Haug, Nancy
T1  - Weekly Patterns of Drug Treatment Attendance.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/05//
VL  - 89
IS  - 5
M3  - Article
SP  - 752
EP  - 755
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined weekly patterns of drug treatment attendance in relation to date of welfare payment receipt and reason for treatment absence. Methods. Treatment attendance by Medicaid-eligible pregnant women who were drug dependent was examined by calendar week over a 29-month period. Results. Time series analyses showed that attendance was lower during week I than week 4. Drug use was the most frequently reported reason for treatment absence during week I (25%) but was not reported as a reason during week 3. conclusions. Drug-dependent. out- patients had increased absences associated with illicit drug use during the first week of the month when welfare payments were received. The generalizability of the findings is unknown. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG abuse -- Treatment
KW  - PATIENT participation
KW  - PATIENT compliance
KW  - HEALTH behavior
KW  - MEDICAL cooperation
N1  - Accession Number: 1804244; Svikis, Dace S. 1; Email Address: dacecap@aol.com Pickens, Roy W. 2 Schweitzer, Wendy 3 Johnson, Eric 4 Haug, Nancy 1; Affiliation:  1: Johns Hopkins University School of Medicine, Baltimore, Md.  2: National Institute on Drug Abuse/Intramural Research Program, Baltimore, Md.  3: Johns Hopkins Bayview Medical Center, Baltimore, Md.  4: Henry Ford Health Sciences Center, Detroit, Mich.; Source Info: May99, Vol. 89 Issue 5, p752; Subject Term: DRUG abuse -- Treatment; Subject Term: PATIENT participation; Subject Term: PATIENT compliance; Subject Term: HEALTH behavior; Subject Term: MEDICAL cooperation; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 4p; Illustrations: 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107137989
T1  - The emerging importance of genetics in epidemiologic research III. Bioinformatics and statistical genetic methods.
AU  - Ellsworth DL
AU  - Manolio TA
Y1  - 1999/05//1999 May
N1  - Accession Number: 107137989. Language: English. Entry Date: 20001001. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; glossary; tables/charts; website. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Epidemiological Research -- Methods
KW  - Genetics
KW  - Medical Informatics -- Utilization
KW  - Disease Susceptibility -- Familial and Genetic
KW  - Biotechnology
KW  - Genes
KW  - Data Analysis, Statistical
KW  - Resource Databases
KW  - Mutation
KW  - Data Analysis Software
SP  - 207
EP  - 224
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 9
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
AB  - PURPOSE: To outline potential benefits of integrating recent developments in bioinformatics and statistical genetics with traditional epidemiologic studies to localize genes influencing complex phenotypes and examine genetic effects on disease susceptibility. METHODS: An overview of bioinformatic and statistical approaches for localizing disease-susceptibility genes as well as challenges associated with identifying functional DNA variants and context-dependent genetic effects concludes this three-part series on the importance of genetics in epidemiologic research. RESULTS: Rapidly evolving bioinformatic and statistical methods are providing invaluable information on newly-discovered genes and molecular variation influencing human diseases that is readily available to epidemiologic researchers. CONCLUSIONS: Integrating bioinformatics and molecular biotechnology with epidemiologic methods of assessing disease risk is rapidly expanding our ability to identify genetic influences on complex human diseases. These technological advances are likely to have a profound impact on current knowledge of complex disease etiology, and may reveal novel approaches to disease treatment and prevention.
SN  - 1047-2797
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Dr, MSC 7934, Bethesda, MD 20892-7934
U2  - PMID: 10332927.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107208525
T1  - Patient resources. Cancer survivorship information resources from the US Government.
AU  - Koyani S
A2  - Lauria MM
A2  - Mora ME
A2  - Varricchio C
Y1  - 1999/05//May/Jun99
N1  - Accession Number: 107208525. Language: English. Entry Date: 19990901. Revision Date: 20150820. Publication Type: Journal Article; website. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. NLM UID: 9312355. 
KW  - Cancer Survivors
KW  - Information Resources
KW  - World Wide Web
SP  - 154
EP  - 156
JO  - Cancer Practice
JF  - Cancer Practice
JA  - CANCER PRACT
VL  - 7
IS  - 3
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 1065-4704
AD  - Office of Cancer Information, Communication, and Education, Patient Education Branch, National Cancer Institute, Bethesda, MD
U2  - PMID: 10352079.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Chae, Jae Jin
AU  - Kim, Sung Han
AU  - Kim, Un Kyung
AU  - Han, Ki-Hoon
AU  - Kim, Hyo-Soo
AU  - Kastner, Daniel L.
AU  - Namkoong, Yong
AU  - Park, Young-Bae
AU  - Lee, Chung Choo
T1  - Three novel small deletion mutations of the LDL receptor gene in Korean patients with familial hypercholesterolemia.
JO  - Clinical Genetics
JF  - Clinical Genetics
Y1  - 1999/05//
VL  - 55
IS  - 5
M3  - Article
SP  - 325
EP  - 331
PB  - Wiley-Blackwell
SN  - 00099163
AB  - The low-density lipoprotein (LDL) receptor gene from 80 unrelated Korean patients with familial hypercholesterolemia (FH) was analyzed to screen for small structural rearrangements that could not be detected by Southern blot hybridization. Three different small deletions were detected in exon 11 of 3 FH patients and were characterized by DNA sequence analysis. Of them two mutations are in-frame 36-bp (FH 2) and 9-bp (FH 34) deletions that result in the loss of twelve amino acids (from Met510 to Ile521) and three amino acids (Thr513, Asp514 and Trp515), respectively. Both mutations are located in the third of the five YWTD motifs of the LDL receptor gene. The third mutation (FH 400) is a 2-bp deletion that shifts the translational reading frame and results in a prematurely terminated receptor protein. The generation of a 36-bp deletion can be explained by the formation of a hairpin-loop structure mediated by inverted repeat sequences. On the other hand, the mechanism responsible for the 9- and the 2-bp deletions is probably strand-slippage mispairing mediated by short direct repeats. All of these three deletions are novel mutations. Each of the three deletions was detected only in a single pedigree out of 80 FH families analyzed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LOW density lipoproteins
KW  - GENES
KW  - HYPERCHOLESTEREMIA
KW  - EXONS (Genetics)
KW  - MUTATION (Biology)
KW  - FH
KW  - LDL receptor gene
KW  - SSCP
KW  - three small deletion mutations
N1  - Accession Number: 5304647; Chae, Jae Jin 1,2 Kim, Sung Han 3 Kim, Un Kyung 1 Han, Ki-Hoon 4 Kim, Hyo-Soo 4 Kastner, Daniel L. 2 Namkoong, Yong 5 Park, Young-Bae 4 Lee, Chung Choo 3; Affiliation:  1: Department of Molecular Biology, Seoul National University, Seoul, South Korea,  2: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA,  3: Department of Biology and SRC for Cell Differentiation, Seoul National University, Seoul 151-742, South Korea,  4: Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea,  5: Department of Biology, Kangnung National University, Kangnung, South Korea; Source Info: May99, Vol. 55 Issue 5, p325; Subject Term: LOW density lipoproteins; Subject Term: GENES; Subject Term: HYPERCHOLESTEREMIA; Subject Term: EXONS (Genetics); Subject Term: MUTATION (Biology); Author-Supplied Keyword: FH; Author-Supplied Keyword: LDL receptor gene; Author-Supplied Keyword: SSCP; Author-Supplied Keyword: three small deletion mutations; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 1 Diagram, 2 Charts; Document Type: Article
L3  - 10.1034/j.1399-0004.1999.550505.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Nechushtan, Amotz
AU  - Smith, Carolyn L.
AU  - Yi-Te Hsu
AU  - Youle, Richard J.
T1  - Conformation of the Bax C-terminus regulates subcellular location and cell death.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/05//5/1/99
VL  - 18
IS  - 9
M3  - Article
SP  - 2330
EP  - 2341
SN  - 02614189
AB  - Bax, a pro-apoptotic member of the Bcl-2 family, translocates from the cytosol to the mitochondria during programmed cell death. We report here that both gain-of-function and loss-of-function mutations can be achieved by altering a single amino acid in the Bax hydrophobic C-terminus. The properly mutated Cterminus of Bax can target a non-relevant protein to the mitochondria, showing that specific conformations of this domain alone allow mitochondrial docking. These data along with N-terminus epitope exposure experiments suggest that the C- and the N-termini interact and that upon triggering of apoptosis, Bax changes conformation, exposing these two domains to insert into the mitochondria and regulate the cell death machinery. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL death
KW  - CELLS
KW  - DEATH (Biology)
KW  - ANTIGENIC determinants
KW  - MITOCHONDRIA
KW  - MUTATION (Biology)
KW  - apoptosis
KW  - bcl-2
KW  - gfp
KW  - mitochondria
KW  - point mutations
N1  - Accession Number: 13004049; Nechushtan, Amotz 1 Smith, Carolyn L. 2 Yi-Te Hsu 1 Youle, Richard J. 1; Email Address: youle@helix.nih.gov; Affiliation:  1: Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA  2: Light Microscopy Facility, Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Instituts of Health, Bethesda, MD 20892, USA; Source Info: 5/1/99, Vol. 18 Issue 9, p2330; Subject Term: CELL death; Subject Term: CELLS; Subject Term: DEATH (Biology); Subject Term: ANTIGENIC determinants; Subject Term: MITOCHONDRIA; Subject Term: MUTATION (Biology); Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: bcl-2; Author-Supplied Keyword: gfp; Author-Supplied Keyword: mitochondria; Author-Supplied Keyword: point mutations; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/18.9.2330
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004049&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gladyshev, Vadim N.
AU  - Hatfield, Dolph L.
T1  - Selenocysteine-Containing Proteins in Mammals.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1999/05//
VL  - 6
IS  - 3
M3  - Article
SP  - 151
EP  - 160
PB  - BioMed Central
SN  - 10217770
AB  - Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words. These selenoproteins have different cellular functions, but in those selenoproteins for which the function is known, selenocysteine is located at the active center. The presence of selenocysteine at critical sites in naturally occurring selenoproteins provides an explanation for the important role of selenium in human health and development. This review describes known mammalian selenoproteins and discusses recent developments and future directions in the selenium field. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AMINO acids
KW  - PROTEINS
KW  - MAMMALS
KW  - HEALTH
KW  - DEVELOPMENTAL biology
KW  - Codon UGA
KW  - Glutathione peroxidase
KW  - Iodothyronine deiodinase
KW  - Selenocysteine
KW  - Selenoenzymes
KW  - Selenoprotein P
KW  - Selenoproteins
KW  - Thioredoxin reductase
N1  - Accession Number: 11372084; Gladyshev, Vadim N. 1 Hatfield, Dolph L. 2; Affiliation:  1: Department of Biochemistry, University of Nebraska, Lincoln, Nebr.  2: Section on the Molecular Biology of Selenium, Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA; Source Info: 1999, Vol. 6 Issue 3, p151; Subject Term: AMINO acids; Subject Term: PROTEINS; Subject Term: MAMMALS; Subject Term: HEALTH; Subject Term: DEVELOPMENTAL biology; Author-Supplied Keyword: Codon UGA; Author-Supplied Keyword: Glutathione peroxidase; Author-Supplied Keyword: Iodothyronine deiodinase; Author-Supplied Keyword: Selenocysteine; Author-Supplied Keyword: Selenoenzymes; Author-Supplied Keyword: Selenoprotein P; Author-Supplied Keyword: Selenoproteins; Author-Supplied Keyword: Thioredoxin reductase; Number of Pages: 10p; Document Type: Article
L3  - 10.1159/000025383
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Vidwans, Aniruddha S.
AU  - Kim, Sungmee
AU  - Coffin, Deborah O.
AU  - Wink, David A.
AU  - Hewett, Sandra J.
T1  - Analysis of the Neuroprotective Effects of Various NitricOxide Donor Compounds in Murine Mixed Cortical Cell Culture.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/05//
VL  - 72
IS  - 5
M3  - Article
SP  - 1843
EP  - 1852
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Nitric oxide (NO) has been implicated in both the pathogenesis of and protection from NMDA receptor-mediated neuronal injury. This apparent paradox has been attributed to alternate redox states of nitrogen monoxide, whereby, depending on the redox milieu, nitrogen monoxide can be neuroprotective via nitrosation chemistry or react with superoxide to form secondary toxic species. In our murine mixed cortical cell culture system, the NONOate-type NO donors diethylamine/NO complex sodium (Dea/NO), (Z)[N-(3-ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium-1,2-diolate (Papa/NO), and spermine/NO complex sodium (Sper/NO), as well as the S-nitrosothiols S-nitroso-L-glutathione (GSNO) and S-nitroso-N-acetyl-D,L-penicillamine (SNAP) (NO+ equivalents), decreased NMDA-induced neuronal injury in a concentration-dependent manner. 8-Bromo-cyclic GMP did not mimic the inhibitory effects of the donors, suggesting that the neuroprotection was not the result of NO-stimulated neuronal cyclic GMP production. Furthermore, neuronal injury induced by exposure of cultures to H2O2 was not altered by the presence of Dea/NO, indicating the absence of a direct antioxidant effect. NONOates did, however, reduce NMDA-stimulated uptake of 45Ca2+, whereas high potassium-induced 45Ca2+ accumulation, a measurement of entry via voltage-gated calcium channels, was unaffected. The parallel reduction of 45Ca2+ accumulation and NMDA neurotoxicity by NONOates mimicked that seen with an NMDA receptor antagonist. Electrochemical measurements of NO via an NO-sensitive electrode demonstrated that neuroprotective concentrations of all donors produced appreciable amounts of NO over the 5-min time frame. Determination of the formation of NO+ equivalents, as assessed by N-nitrosation of 2,3-diaminonaphthylene, revealed little or no observable N-nitrosation by Sper/NO, GSNO, and SNAP with significant N-nitrosation observed by Papa/NO and Dea/NO. However, addition of ascorbate (400 μM) effectively prevented the nitrosation of 2,3-diaminonaphthylene produced by Dea/NO and Papa/NO without altering their neuroprotective properties or their effects on 45Ca2+ accumulation. Present results indicate that the intrinsic NO/NO+ characteristics of NO donor compounds may not be a good predictor of their ability to inhibit NMDA receptor-mediated neurotoxicity at the cellular level. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NITRIC oxide
KW  - METHYL aspartate
KW  - NEURONS
KW  - NITROSATION
KW  - Murine mixed cortical cell culture
KW  - Nitric oxide donors
KW  - NMDA-induced neurotoxicity
KW  - NONOate-type nitric oxide donors
KW  - S-Nitrosothiols
N1  - Accession Number: 6007078; Vidwans, Aniruddha S. Kim, Sungmee 1 Coffin, Deborah O. 1 Wink, David A. 1 Hewett, Sandra J. 2; Affiliation:  1: Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.  2: Department of Pharmacology, Program in Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, U.S.A.; Source Info: May99, Vol. 72 Issue 5, p1843; Subject Term: NITRIC oxide; Subject Term: METHYL aspartate; Subject Term: NEURONS; Subject Term: NITROSATION; Author-Supplied Keyword: Murine mixed cortical cell culture; Author-Supplied Keyword: Nitric oxide donors; Author-Supplied Keyword: NMDA-induced neurotoxicity; Author-Supplied Keyword: NONOate-type nitric oxide donors; Author-Supplied Keyword: S-Nitrosothiols; Number of Pages: 10p; Illustrations: 1 Chart, 13 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yang, Hsiu-Ying T.
AU  - Karoum, Farouk
AU  - Felder, Christian
AU  - Badger, Henry
AU  - Wang, Tao-Chin Lin
AU  - Markey, Sanford P.
T1  - GC/MS Analysis of Anandamide and Quantification of N-Arachidonoylphosphatidylethanolamides in Various Brain Regions, Spinal Cord, Testis, and Spleen of the Rat.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/05//
VL  - 72
IS  - 5
M3  - Article
SP  - 1959
EP  - 1968
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Anandamide [N-arachidonoylethanolamide (NAE)] was initially isolated from porcine brain and proposed as an endogenous ligand for cannabinoid receptors in 1992. Accumulating evidence has now suggested that, in the tissue, NAE is generated from N-arachidonoylphosphatidylethanolamides (N-ArPEs) by phosphodiesterase. In this study a sensitive and specific procedure was developed to quantify NAE and N-ArPE, including organic solvent extraction, reverse-phase C-18 cartridge separation, derivatization, and gas chromatography/mass spectrometry (GC/MS) analysis. NAE is converted by a two-step derivatization procedure to a pentafluorobenzoyl ester followed by pentafluoropropionyl acylation. Quantification was performed by isotope dilution GC/MS using deuterium-labeled NAE (NAE-2H8) as an internal standard. The same chemical derivatization was applicable to N-ArPE quantification. The separated N-ArPE fractions were converted by a two-step cleavage/derivatization procedure into the pentafluorobenzoyl ester of NAE and then to its pentafluoropropionyl amide. The derivative was quantified by GC/MS using deuterium-labeled 1,2-[2H8]dioleoyl-sn-glycero-3-phospho(arachidonoyl)ethanolamide as an internal standard. Using these methods, we have found that endogenous NAE levels in rat brain, spleen, testis, liver, lung, and heart were below the level of quantification achievable (0.1 pmol/mg of protein) but that N-ArPE is readily quantifiable and is widely distributed in the rat CNS with the highest level in the spinal cord. The striatum, hippocampus, and accumbens contain intermediate concentrations of N-ArPE, whereas the value is lowest in the cerebellum. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GAS chromatography
KW  - MASS spectrometry
KW  - Anandamide
KW  - Deuterium labeling
KW  - Endogenous cannabinoid
KW  - Gas chromatography/mass spectrometry
KW  - N-Arachidonoylphosphatidylethanolamides
KW  - Reverse-phase C-18 cartridge
N1  - Accession Number: 6007065; Yang, Hsiu-Ying T. Karoum, Farouk Felder, Christian 1 Badger, Henry 2 Wang, Tao-Chin Lin 2 Markey, Sanford P. 2; Affiliation:  1: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, U.S.A.  2: Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, Maryland, U.S.A.; Source Info: May99, Vol. 72 Issue 5, p1959; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Anandamide; Author-Supplied Keyword: Deuterium labeling; Author-Supplied Keyword: Endogenous cannabinoid; Author-Supplied Keyword: Gas chromatography/mass spectrometry; Author-Supplied Keyword: N-Arachidonoylphosphatidylethanolamides; Author-Supplied Keyword: Reverse-phase C-18 cartridge; Number of Pages: 10p; Illustrations: 1 Diagram, 4 Charts, 7 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Morrison, Paul F.
AU  - Morishige, Gregory M.
AU  - Beagles, Karen E.
AU  - Heyes, Melvyn P.
T1  - Quinolinic Acid Is Extruded from the Brain by a Probenecid-Sensitive Carrier System.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/05//
VL  - 72
IS  - 5
M3  - Article
SP  - 2135
EP  - 2144
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Although the neurotoxic tryptophan-kynurenine pathway metabolite quinolinic acid originates in brain by both local de novo synthesis and entry from blood, its concentrations in brain parenchyma, extracellular fluid, and CSF are normally below blood values. In the present study, an intraperitoneal injection of probenecid (400 mg/kg), an established inhibitor of acid metabolite transport in brain, into gerbils, increased quinolinic acid concentrations in striatal homogenates, CSF, serum, and homogenates of kidney and liver. Direct administration of probenecid (10 mM) into the brain compartment via an in vivo microdialysis probe implanted into the striatum also caused a progressive elevation in both quinolinic acid and homovanillic acid concentrations in the extracellular fluid compartment but was without effect on serum quinolinic acid levels. A model of microdialysis transport showed that the elevations in extracellular fluid quinolinic acid and homovanillic acid levels following intrastriatal application are consistent with probenecid block of a microvascular acid transport mechanism. We conclude that quinolinic acid in brain is maintained at concentrations below blood levels largely by active extrusion via a probenecid-sensitive carrier system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - QUINOLINIC acid
KW  - METHYL aspartate
KW  - Blood
KW  - brain barrier
KW  - efflux transport
KW  - In vivo microdialysis
KW  - Probenecid
KW  - Quinolinic acid
N1  - Accession Number: 6007041; Morrison, Paul F. Morishige, Gregory M. 1 Beagles, Karen E. 1 Heyes, Melvyn P. 1; Affiliation:  1: Laboratory of Neurotoxicology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May99, Vol. 72 Issue 5, p2135; Subject Term: QUINOLINIC acid; Subject Term: METHYL aspartate; Author-Supplied Keyword: Blood; Author-Supplied Keyword: brain barrier; Author-Supplied Keyword: efflux transport; Author-Supplied Keyword: In vivo microdialysis; Author-Supplied Keyword: Probenecid; Author-Supplied Keyword: Quinolinic acid; Number of Pages: 10p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107208325
T1  - Observations. Changing patterns of disease and mucosal immunity.
AU  - Slavkin HC
Y1  - 1999/05//
N1  - Accession Number: 107208325. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Mouth Diseases -- Immunology
KW  - Mouth Mucosa -- Immunology
KW  - Antibody Formation
KW  - Immunity
SP  - 735
EP  - 738
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 5
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, MD 20892-2290
U2  - PMID: 10332139.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107231109
T1  - Associations of symptoms of sleep apnea with cardiovascular disease, cognitive impairment, and mortality among older Japanese-American men.
AU  - Foley DJ
AU  - Monjan AA
AU  - Masaki KH
AU  - Enright PL
AU  - Quan SF
AU  - White LR
Y1  - 1999/05//5/ 1/1999
N1  - Accession Number: 107231109. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Cognitive Abilities Screening Instrument (CASI). Grant Information: Contracts NHLBI NO1-HC-02901 and NIA NO1-AG-4-2149. NLM UID: 7503062. 
KW  - Japanese
KW  - Cardiovascular Diseases -- Complications
KW  - Cardiovascular Diseases -- Epidemiology
KW  - Cognition Disorders -- Complications
KW  - Cognition Disorders -- Epidemiology
KW  - Sleep Apnea Syndromes -- Complications
KW  - Sleep Apnea Syndromes -- Epidemiology
KW  - Multiple Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Data Analysis Software
KW  - Clinical Assessment Tools
KW  - Cardiovascular Diseases -- Mortality
KW  - Cognition Disorders -- Mortality
KW  - Hawaii
KW  - Japan
KW  - Prospective Studies
KW  - Funding Source
KW  - Sleep Apnea Syndromes -- Mortality
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Human
SP  - 524
EP  - 528
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVES: To examine the association between symptoms of sleep apnea and prevalent cardiovascular disease, cognitive impairment, and subsequent 3-year mortality. DESIGN: A longitudinal study. SETTING: Participants lived in the community on Oahu, Hawaii. PARTICIPANTS: A total of 2905 older Japanese-American men participating in the fourth examination of the Honolulu Heart Program cohort study from 1991-1993, which is the baseline for the Honolulu-Asia Aging Study of dementia. MEASUREMENTS: Self-reported snoring, daytime sleepiness, and breathing pauses; diagnosed cardiovascular disease and dementia; cognitive functioning and vital status approximately 3 years later. RESULTS: More than 12% of the participants reported that they often or always snored loudly, and 8% reported being sleepy most of the day. Fewer than 2% reported that they stop breathing when sleeping, and this was found more frequently among habitual snorers (7%, P < .001) and those sleepy during the day (5%, P < .001). The prevalence of habitual snoring declined in the older age groups, was higher among those with greater Body Mass Index scores, and was not associated with the reporting of daytime sleepiness, diagnosis of heart disease, stroke, dementia, or cognitive impairment. Daytime sleepiness was more prevalent at older ages and was associated with a higher prevalence of heart disease and with cognitive impairment and dementia, chronic obstructive pulmonary disease, and diabetes. Self-reported apnea was associated only with a history of pneumonia. Three-year mortality was not associated with these symptoms after adjusting for prevalent heart disease and cognitive impairment. CONCLUSION: Symptoms of sleep apnea are reported less frequently in older Japanese-American men. Excessive daytime sleepiness is associated with poor cognition and dementia, but whether it also is an indicator for sleep apnea in this age group remains unclear. Epidemiologic studies of sleep apnea in older adults will require polysomnography to determine accurately the correlates and consequences of this condition.
SN  - 0002-8614
AD  - Rm 3C-309, Bethesda Gateway Bldg., National Institute on Aging, 7201 Wisconsin Ave., Bethesda, MD 20892-9205
U2  - PMID: 10323643.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rimer, Barbara K.
AU  - Halabi, Susan
AU  - Strigo, Tara S.
AU  - Crawford, Yancey
AU  - Lipkus, Isaac M.
T1  - Confusion about Mammography: Prevalence and Consequences.
JO  - Journal of Women's Health & Gender-Based Medicine
JF  - Journal of Women's Health & Gender-Based Medicine
Y1  - 1999/05//
VL  - 8
IS  - 4
M3  - Article
SP  - 509
PB  - Mary Ann Liebert, Inc.
SN  - 15246094
AB  - The article focuses on a study which examined women's behaviors and beliefs about mammography after the visible controversies about the recommendations in the aftermath of the January 1997 National Institutes of Health Consensus Development Conference on Breast Cancer Screening For Women ages 40-49. The data described in this analysis were derived from a baseline telephone interview conducted as part of a larger intervention trial. Study measures included a variety of sociodemographic, medical, belief, and behavioral variables. Overall, 28% of women were confused, and 35% were off schedule. Although a higher proportion of women in their 40s than 50s were confused, more women in their 50s were off schedule. Confusion was a significant predictor for the outcome being off schedules. Researchers reported a telephone survey of 1024 women in Washington State to examine how conflicting national recommendations in 1994 affected use of screening mammography. About one half the women in the sample were aware of the conflicting recommendations. The authors concluded that awareness of conflicting recommendations was not related to decreased use of mammography.
KW  - MAMMOGRAMS
KW  - CANCER in women
KW  - BREAST cancer
KW  - WOMEN -- Health
KW  - NATIONAL Institutes of Health (U.S.) -- Congresses
KW  - UNITED States
N1  - Accession Number: 5624358; Rimer, Barbara K. 1 Halabi, Susan 2 Strigo, Tara S. 3 Crawford, Yancey 3 Lipkus, Isaac M. 3; Affiliation:  1: Division of Cancer Control and Population Science, National Cancer Institute, Bethesda, Maryland.  2: Division of Biometry, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.  3: Cancer Prevention, Detection and Control Research Program, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina.; Source Info: May99, Vol. 8 Issue 4, p509; Subject Term: MAMMOGRAMS; Subject Term: CANCER in women; Subject Term: BREAST cancer; Subject Term: WOMEN -- Health; Subject Term: NATIONAL Institutes of Health (U.S.) -- Congresses; Subject Term: UNITED States; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107220159
T1  - Confusion about mammography: prevalence and consequences.
AU  - Rimer BK
AU  - Halabi S
AU  - Strigo TS
AU  - Crawford Y
AU  - Lipkus IM
Y1  - 1999/05//
N1  - Accession Number: 107220159. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Gail Score; Decisional Balance (DB) Scale; Abbreviated 10-item Version of the Center for Epidemiology Depression Scale. NLM UID: 100888719. 
KW  - Mammography -- Psychosocial Factors
KW  - Appointments and Schedules
KW  - Confusion -- Epidemiology
KW  - Health Knowledge
KW  - Evaluation Research
KW  - Epidemiological Research
KW  - Mammography -- Utilization
KW  - Attitude to Health
KW  - Attitude Measures
KW  - Stratified Random Sample
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Insurance, Health
KW  - Telephone
KW  - Interviews
KW  - Surveys
KW  - Questionnaires
KW  - Breast Neoplasms -- Prevention and Control
KW  - Cancer Screening
KW  - Psychological Tests
KW  - Pearson's Correlation Coefficient
KW  - Chi Square Test
KW  - T-Tests
KW  - Coefficient Alpha
KW  - Logistic Regression
KW  - P-Value
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Independent Variable
KW  - Goodness of Fit Chi Square Test
KW  - Descriptive Statistics
KW  - Whites
KW  - Blacks
KW  - Demography
KW  - Health Beliefs
KW  - Women's Health
KW  - Human
SP  - 509
EP  - 520
JO  - Journal of Women's Health & Gender-Based Medicine
JF  - Journal of Women's Health & Gender-Based Medicine
JA  - J WOMENS HEALTH GENDER BASED MED
VL  - 8
IS  - 4
CY  - New Rochelle, New York
PB  - Mary Ann Liebert, Inc.
AB  - Over the last decade, there has been significant controversy about the schedule on which women, particularly women in their 40s, should have mammograms. The purpose of the analysis reported here was to assess whether women in their 40s and 50s were confused as a result of the controversy following the January 1997 National Institutes of Health Consensus Development Conference on Breast Cancer Screening For Women Ages 40-49. We also examined if confusion was related to being off schedule for mammography. The study sample included 1287 women recruited from a random sample of 2165 Blue Cross/Blue Shield of North Carolina members. The data described in this analysis were derived from a baseline telephone interview conducted as part of a larger intervention trial. Study measures included a variety of sociodemographic, medical, belief, and behavioral variables. Overall, 28% of women were confused, and 35% were off schedule. Although a higher proportion of women in their 40s than 50s were confused, more women in their 50s were off schedule. Confusion was a significant predictor for the outcome being off schedule. Predictors of confusion included several belief variables, risk perceptions, age (40s), whether the woman had a regular physician, and whether she had enough information about mammography. Healthcare providers should ask some simple questions to determine if women are confused and then seek to meet their information needs.
SN  - 1524-6094
AD  - Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Plaza N, Room 242, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107204256
T1  - Muscle quality and age: cross-sectional and longitudinal comparisons.
AU  - Metter EJ
AU  - Lynch N
AU  - Conwit R
AU  - Lindle R
AU  - Tobin J
AU  - Hurley B
Y1  - 1999/05//
N1  - Accession Number: 107204256. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9502837. 
KW  - Muscle Strength
KW  - Aging -- Physiology
KW  - Cross Sectional Studies
KW  - Prospective Studies
KW  - Exercise Test, Muscular
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Analysis of Variance
KW  - Isometric Exercises
KW  - P-Value
KW  - Regression
KW  - Arm -- Physiology
KW  - Leg -- Physiology
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - B207
EP  - 18
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 54A
IS  - 5
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - National Institute on Aging, Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224-6823; e-mail: Jeffrey@vax.grc.nia.nih.gov
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106893101
T1  - Use of Medicare hospital and physician data to assess breast cancer incidence.
AU  - Warren JL
AU  - Feuer E
AU  - Potosky AL
AU  - Riley GF
AU  - Lynch CF
Y1  - 1999/05//1999 May
N1  - Accession Number: 106893101. Language: English. Entry Date: 20020118. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027. 
KW  - Breast Neoplasms -- Epidemiology -- In Old Age
KW  - Medicare
KW  - Registries, Disease
KW  - Logistic Regression
KW  - National Cancer Institute (U.S.)
KW  - Record Review
KW  - Descriptive Research
KW  - Descriptive Statistics
KW  - International Classification of Diseases
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Billing and Claims
KW  - Current Procedural Terminology
KW  - Aged
KW  - Female
KW  - Human
SP  - 445
EP  - 456
JO  - Medical Care
JF  - Medical Care
JA  - MED CARE
VL  - 37
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0025-7079
AD  - Applied Research Branch, National Cancer Institute, Executive Plaza North, Room 131, 6130 Executive Blvd, Bethesda, MD 20892-7344
U2  - PMID: 10335747.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kochl, Richard
AU  - De La Cruz, Felix
T1  - Historical aspects and overview of research on phenylketonuria.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1999/05//
VL  - 5
IS  - 2
M3  - Article
SP  - 101
EP  - 103
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - The article presents the historical background of the disease phenylketonuria (PKU). The disease was first described in 1934 in Norway. Patients with the disease exhibit increased level of phenylketone in their urine and suffer from serious degree of mental retardation. Researchers found that the disease was caused by hyperphenylalaninemia. It is a localized enzyme defect of the liver where phenylalanine is converted to tyrosine in the unaffected individual. The first major breakthrough in the treatment of the disease occurred when researcher Horst Bickel demonstrated improvement in a severely affected child with PKU by using phenylalanine-restricted diet.
KW  - PHENYLKETONURIA
KW  - PHENYLALANINE
KW  - MENTAL disabilities
KW  - ENZYMES
KW  - LIVER diseases
KW  - NEWBORN infants
KW  - newborn screening
KW  - phenylalanine
KW  - phenylalaninehydroxylase
KW  - phenylketonuria
N1  - Accession Number: 11782000; Kochl, Richard 1; Email Address: rkoch8@juno.com De La Cruz, Felix 2; Affiliation:  1: University of Southern California School of Medicine, Los Angeles California.  2: Mental Retardation and Developmental Disabilities Branch, National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1999, Vol. 5 Issue 2, p101; Subject Term: PHENYLKETONURIA; Subject Term: PHENYLALANINE; Subject Term: MENTAL disabilities; Subject Term: ENZYMES; Subject Term: LIVER diseases; Subject Term: NEWBORN infants; Author-Supplied Keyword: newborn screening; Author-Supplied Keyword: phenylalanine; Author-Supplied Keyword: phenylalaninehydroxylase; Author-Supplied Keyword: phenylketonuria; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Koch, R.
AU  - Friedman, E.
AU  - Azen, C.
AU  - Hanley, W.
AU  - Levy, H.
AU  - Matalon, R.
AU  - Rouse, B.
AU  - Trefz, F.
AU  - Waisbren, S.
AU  - Michals-Matalon, K.
AU  - Acosta, P.
AU  - Guttler, F.
AU  - Ullrich, K.
AU  - Platt, L.
AU  - De La Cruz, F.
T1  - The International Collaborative Study of Maternal Phenylketonuria status report 1998.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1999/05//
VL  - 5
IS  - 2
M3  - Article
SP  - 117
EP  - 121
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - The Maternal PKU Study began in 1984 and during the intervening years, 572 pregnancies in women with hyperphenylalaninemia (HPA) and 99 controls and their outcomes have been evaluated. Among Women with HPA who delivered a live infant, only 15.9% were treated and in metabolic control preconceptionally; however, another 18.4% were in control by 10 weeks. Compared to the results reported by Lenke and Levy in 1980, there is a marked improvement in outcome with treatment. Microcephaly was unusual in preconceptionally treated pregnancies with well-controlled phenylalanine-restricted diets. Even in pregnancies that established control after conception but before the 8th week, congenital heart disease did not occur in the offspring; however, it did occur in 12% of pregnancies not achieving control until after 10 weeks of pregnancy. The recommended level of blood phenylalanine during pregnancy is 120–360 μmol/L. Best results were obtained by close cooperation between the attending obstetrician and a metabolic team experienced in the care of persons with phenylketonuria. MRDD Research Reviews 1999;5:117–121. © 1999 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANCY
KW  - ANEMIA
KW  - NEWBORN infants
KW  - CONGENITAL heart disease
KW  - MICROCEPHALY
KW  - PHENYLALANINE
KW  - DIET
KW  - PHENYLKETONURIA
KW  - congenital heart disease
KW  - Maternal Phenylketonuria Collaborative Study
KW  - phenyl-ketonuria
KW  - phenylalanine
KW  - Wechsler Adult Intelligence Quotient-Revised (WAIS-R)
KW  - Wechsler Intelligence Quotient-Revised (WlSR)
N1  - Accession Number: 11781995; Koch, R. 1 Friedman, E. 1 Azen, C. 1 Hanley, W. 2 Levy, H. 3 Matalon, R. 4 Rouse, B. 4 Trefz, F. 5 Waisbren, S. 3 Michals-Matalon, K. 4 Acosta, P. 6 Guttler, F. 7 Ullrich, K. 8 Platt, L. 9 De La Cruz, F. 10; Affiliation:  1: Childrens Hospital Los Angeles, Division of Medical Genetics and University of Southern California, Department of Pediatrics, Los Angeles, California.  2: The Hospital for Sick Children, PKU Program, Toronto, Ontario, Canada.  3: Childrens Hospital and Medical Center, Boston, Massachusetts.  4: Child Development Division, University of Texas, Medical Branch, Galveston, Texas.  5: Universität Tubingen, Reutlingen, Germany.  6: Ross Laboratories, Columbus, Ohio.  7: The John F. Kennedy Institute, Glostrup, Denmark.  8: Department of Pediatrics, University of Münster, Münster, Germany.  9: Cedars- Sinai Medical Center, Department of Obstetrics and Gynecology, U CLA Medical Center, Los Angeles, California.  10: National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1999, Vol. 5 Issue 2, p117; Subject Term: PREGNANCY; Subject Term: ANEMIA; Subject Term: NEWBORN infants; Subject Term: CONGENITAL heart disease; Subject Term: MICROCEPHALY; Subject Term: PHENYLALANINE; Subject Term: DIET; Subject Term: PHENYLKETONURIA; Author-Supplied Keyword: congenital heart disease; Author-Supplied Keyword: Maternal Phenylketonuria Collaborative Study; Author-Supplied Keyword: phenyl-ketonuria; Author-Supplied Keyword: phenylalanine; Author-Supplied Keyword: Wechsler Adult Intelligence Quotient-Revised (WAIS-R); Author-Supplied Keyword: Wechsler Intelligence Quotient-Revised (WlSR); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bahro, Marcel
AU  - Molchan, Susan E.
AU  - Sunderland, Trey
AU  - Herscovitch, Peter
AU  - Schreurs, Bernard G.
T1  - The Effects of Scopolamine on Changes in Regional Cerebral Blood Flow during Classical Conditioning of the Human Eyeblink Response.
JO  - Neuropsychobiology
JF  - Neuropsychobiology
Y1  - 1999/05//
VL  - 39
IS  - 4
M3  - Article
SP  - 187
EP  - 195
SN  - 0302282X
AB  - We examined the effects of scopolamine on the functional anatomy of classical conditioning of the human eyeblink response. Ten healthy young normal female volunteers (mean age ± SEM: 26.7 ± 0.9 years) were administered 0.4 mg scopolamine intravenously 1 h before regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and H[sub 2] [sup 15] O. Scans occurred during three sequential phases: (1) explicitly unpaired presentations of the unconditioned stimulus (airpuff to the right eye) and conditioned stimulus (binaural tone), (2) paired presentations of the two stimuli (associative learning) and (3) explicitly unpaired presentation of the stimuli (extinction phase). Scopolamine impaired acquisition of the conditioned eyeblink response (54.7 ± 4.9%) relative to 18 untreated subjects from two previous PET studies. Regions that showed significant relative increases in rCBF during conditioning included the right lateral occipital cortex, the right inferior occipital cortex, the right lateral temporo-occipital cortex, the left medial temporo-occipital cortex, the posterior cingulate, the right cerebellum/brain stem area and the medial cerebellum. Significant relative decreases in rCBF were measured in the thalamus, the left putamen/insula area, the right putamen and the left and middle cerebellar cortex. The data partially replicate previous findings in unmedicated young volunteers of conditioning-specific rCBF changes in the cingulate cortex, the cerebellar cortex, the insula and the lateral temporo-occipital cortex. Our finding of decreased rCBF in the thalamus and increased rCBF in the occipital cortex may be attributable to effects of scopolamine per se rather than conditioning. Our data lend further support to the notion that classical conditioning involves distributed changes in multiple systems within the central nervous system. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Neuropsychobiology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CEREBRAL circulation
KW  - BLOOD circulation
KW  - EYE -- Movements
KW  - SCOPOLAMINE
KW  - PARASYMPATHOLYTIC agents
KW  - MEMORY
KW  - Classical conditioning
KW  - Eyeblink
KW  - Human
KW  - Positron emission tomography
KW  - Regional cerebral blood flow
KW  - Scopolamine
N1  - Accession Number: 11378203; Bahro, Marcel 1 Molchan, Susan E. 1 Sunderland, Trey 1 Herscovitch, Peter 2 Schreurs, Bernard G. 3; Affiliation:  1: Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health  2: Positron Emission Tomography Department, National Institutes of Health Clinical Center  3: Behavioral Neuroscience Unit, Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md., USA; Source Info: 1999, Vol. 39 Issue 4, p187; Subject Term: CEREBRAL circulation; Subject Term: BLOOD circulation; Subject Term: EYE -- Movements; Subject Term: SCOPOLAMINE; Subject Term: PARASYMPATHOLYTIC agents; Subject Term: MEMORY; Author-Supplied Keyword: Classical conditioning; Author-Supplied Keyword: Eyeblink; Author-Supplied Keyword: Human; Author-Supplied Keyword: Positron emission tomography; Author-Supplied Keyword: Regional cerebral blood flow; Author-Supplied Keyword: Scopolamine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3  - 10.1159/000026582
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Peruselli, C.
AU  - Di Giulio, P.
AU  - Toscani, F.
AU  - Gallucci, M.
AU  - Brunelli, C.
AU  - Costantini, M.
AU  - Tamburini, M.
AU  - Paci, E.
AU  - Miccinesi, G.
AU  - Addington-Hall, J.M.
AU  - Higginson, I.J.
T1  - Home palliative care for terminal cancer patients: a survey on the final week of life.
JO  - Palliative Medicine
JF  - Palliative Medicine
Y1  - 1999/05//
VL  - 13
IS  - 3
M3  - Article
SP  - 233
EP  - 241
SN  - 02692163
AB  - As part of a large multicentre study on palliative care units in Italy, carried out between 1 January and 30 June 1995, we describe the place, circumstances and `quality of death' of patients admitted to home palliative care. Data presented refer to 401 patients (67% of the 601 patients randomly selected for evaluation). Of these 401 patients 303 (76%) died at home. According to the Support Team Assessment Schedule (STAS) pain was fairly well controlled during the final week of life, while the control of other symptoms appeared to be less satisfactory. Invasive procedures were undertaken on 56% of patients, while in hospital the percentage increased to 75%. Twenty-five per cent of patients were totally pharmacologically sedated during the final 12 h of life. Neither the number of symptoms nor other factors were apparently associated with the decision to sedate the patient. The wide variations in the frequency of sedation among centres suggest that the choice to sedate the patient may reflect the provider's behaviour or services' policy rather than the patients' preference or needs. The definition of common criteria and guidelines for sedation of patients should be one of the topics for discussion among palliative care teams. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Palliative Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PALLIATIVE treatment
KW  - HOME care services
N1  - Accession Number: 2003561; Peruselli, C. 1 Di Giulio, P. 2 Toscani, F. 3 Gallucci, M. 4 Brunelli, C. 5 Costantini, M. 6 Tamburini, M. 5 Paci, E. 7 Miccinesi, G. 8 Addington-Hall, J.M. 9 Higginson, I.J. 9; Affiliation:  1: Palliative Care Service, Merate Hospital, L.go Mandic 1, 22055 Merate (Lc), Milan, Italy  2: Nursing Research Unit, Mario Negri Institute, Milan, Italy  3: Palliative Care Unit, Cremona Hospital, Milan, Italy  4: Palliative Care Unit, Desio Hospital, Milan, Italy  5: Psychology Division, National Cancer Institute, Milan, Italy  6: Department of Epidemiology, National Cancer Institute, Genova, Italy  7: Department of Epidemiology, Center for the Study and Prevention of Cancer, Florence, Italy  8: Center for the Study and Prevention of Cancer, Florence, Italy  9: Department of Palliative Care and Policy, King's College School of Medicine and Dentistry, London, United Kingdom; Source Info: 1999, Vol. 13 Issue 3, p233; Subject Term: PALLIATIVE treatment; Subject Term: HOME care services; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 4493
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Henske, Elizabeth Petri
AU  - Thorner, Paul
AU  - Patterson, Kathleen
AU  - Zhuang, Zhengping
AU  - Bernstein, Jay
T1  - Renal Cell Carcinoma in Children with Diffuse Cystic Hyperplasia of the Kidneys.
JO  - Pediatric & Developmental Pathology
JF  - Pediatric & Developmental Pathology
Y1  - 1999/05//
VL  - 2
IS  - 3
M3  - Article
SP  - 270
EP  - 274
SN  - 10935266
N1  - Accession Number: 71790904; Henske, Elizabeth Petri 1 Thorner, Paul 2 Patterson, Kathleen 3 Zhuang, Zhengping 4 Bernstein, Jay 5; Affiliation:  1: Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA , US  2: Department of Pediatric Laboratory Medicine, Division of Pathology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8 , CA  3: Department of Pathology, Children's Hospital and Medical Center, 4800 Sandpoint Way NE, Seattle, WA 98105, USA , US  4: Department of Pathology, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA , US  5: William Beaumont Research Institute, 3601 West 13 Mile Road, Royal Oak, MI 48073-6769, USA , US; Source Info: May1999, Vol. 2 Issue 3, p270; Number of Pages: 5p; Document Type: Article
L3  - 10.1007/s100249900123
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107192646
T1  - The ethical foundation of informed consent in clinical research.
AU  - McCabe MS
Y1  - 1999/05//1999 May
N1  - Accession Number: 107192646. Language: English. Entry Date: 19990601. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Research Ethics
KW  - Consent (Research)
KW  - Clinical Trials
KW  - Research Subjects
KW  - Theory
KW  - Patient Autonomy
SP  - 76
EP  - 80
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 15
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To provide a foundation for understanding the ethical concept of informed consent with particular emphasis on the characteristics and principles that make it a moral imperative. DATA SOURCES: Government reports, published articles, and book chapters from the ethics literature. CONCLUSIONS: Informed consent is central to the conduct of cancer clinical trials and good patient care. It is a thoughtful, collaborative process whereby an individual gives autonomous authorization and the decision of the individual is respected by the health professionals. IMPLICATIONS FOR NURSING PRACTICE: Understanding the theory and practice of informed consent is an essential aspect of the nurses role. There are many challenges to this process in the oncology setting because of the severity of the diseases and the complexity of the research, and nurses must be prepared to assure that informed decision-making takes place. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0749-2081
AD  - Office of Clinical Research Promotion, National Cancer Institute, Bldg 31, Room 3A-44, Bethesda, MD 20892
U2  - PMID: 10222506.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107192660
T1  - National efforts to improve the informed consent process.
AU  - Padberg RM
AU  - Flach J
Y1  - 1999/05//1999 May
N1  - Accession Number: 107192660. Language: English. Entry Date: 19990601. Revision Date: 20150819. Publication Type: Journal Article; forms. Journal Subset: Core Nursing; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8504688. 
KW  - Consent (Research)
KW  - Clinical Trials
KW  - National Cancer Institute (U.S.)
KW  - Government Agencies -- United States
KW  - United States
KW  - Financing, Government -- United States
SP  - 138
EP  - 144
JO  - Seminars in Oncology Nursing
JF  - Seminars in Oncology Nursing
JA  - SEMIN ONCOL NURS
VL  - 15
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - OBJECTIVES: To inform oncology nurses about several national efforts to improve the informed consent document and process. DATA SOURCES: A federally funded grant program to stimulate research of informed consent, an initiative from the National Cancer Institute to improve informed consent documents in cancer clinical trials, and a model consent document developed by the National Action Plan on Breast Cancer. CONCLUSIONS: These initiatives assist investigators and institutional review boards in presenting relevant and understandable information to potential clinical trial participants. IMPLICATIONS FOR NURSING PRACTICE: These national efforts will raise awareness of providing potential research participants with clear information to assist them in making an educated, informed decision. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0749-2081
AD  - Department of Early Detection and Community Oncology and the Rehabilitation Branch, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD
U2  - PMID: 10222513.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Goering, Peter L.
AU  - Aposhian, H. Vasken
AU  - Mass, Marc J.
AU  - Cebrián, Mariano
AU  - Beck, Barbara D.
AU  - Waalkes, Michael P.
T1  - Forum. The enigma of arsenic carcinogenesis: role of metabolism.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/05//
VL  - 49
IS  - 1
M3  - Article
SP  - 5
EP  - 14
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Inorganic arsenic is considered a high-priority hazard, particularly because of its potential to be a human carcinogen. In exposed human populations, arsenic is associated with tumors of the lung, skin, bladder, and liver. While it is known to be a human carcinogen, carcinogenesis in laboratory animals by this metalloid has never been convincingly demonstrated. Therefore, no animal models exist for studying molecular mechanisms of arsenic carcinogenesis. The apparent human sensitivity, combined with our incomplete understanding about mechanisms of carcinogenic action, create important public health concerns and challenges in risk assessment, which could be met by understanding the role of metabolism in arsenic toxicity and carcinogenesis. This symposium summary covers three critical major areas involving arsenic metabolism: its biodiversity, the role of arsenic metabolism in molecular mechanisms of carcinogenesis, and the impact of arsenic metabolism on human risk assessment. In mammals, arsenic is metabolized to mono- and dimethylated species by methyltransferase enzymes in reactions that require S-adenosyl-methionine (SAM) as the methyl donating cofactor. A remarkable species diversity in arsenic methyltransferase activity may account for the wide variability in sensitivity of humans and animals to arsenic toxicity. Arsenic interferes with DNA methyltransferases, resulting in inactivation of tumor suppressor genes through DNA hypermethylation. Other studies suggest that arsenic-induced malignant transformation is linked to DNA hypomethylation subsequent to depletion of SAM, which results in aberrant gene activation, including oncogenes. Urinary profiles of arsenic metabolites may be a valuable tool for assessing human susceptibility to arsenic carcinogenesis. While controversial, the idea that unique arsenic metabolic properties may explain the apparent non-linear threshold response for arsenic carcinogenesis in humans. In order to address these outstanding issues, further efforts are required to identify an appropriate animal model to elucidate carcinogenic mechanisms of action, and to define dose-response relationships. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Arsenic
KW  - Carcinogenicity
KW  - Carcinogens
KW  - Mammals
KW  - Methyltransferases
N1  - Accession Number: 44405750; Goering, Peter L. 1; Email Address: plg@cdrh.fda.gov; Aposhian, H. Vasken 2; Mass, Marc J. 3; Cebrián, Mariano 4; Beck, Barbara D. 5; Waalkes, Michael P. 6; Affiliations: 1: Division of Life Sciences, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland; 2: Department of Molecular and Cellular Biology, and Center for Toxicology, The University of Arizona, Tucson, Arizona; 3: Biochemistry and Pathobiology Branch, Environmental Carcinogenesis Division, National Health and Environmental Effects Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina; 4: Sección de Toxicología Ambiental, CINVESTAV, Mexico, DF; 5: Gradient Corporation, Cambridge, Massachusetts; 6: Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Issue Info: May1999, Vol. 49 Issue 1, p5; Thesaurus Term: Arsenic; Thesaurus Term: Carcinogenicity; Thesaurus Term: Carcinogens; Thesaurus Term: Mammals; Subject Term: Methyltransferases; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 10p; Illustrations: 3 Diagrams, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Bucher, John R.
AU  - Hailey, J. R.
AU  - Roycroft, Joseph R.
AU  - Haseman, Joseph K.
AU  - Sills, Robert C.
AU  - Grumbein, S. L.
AU  - Mellick, P. W.
AU  - Chou, B. J.
T1  - Inhalation toxicity and carcinogenicity studies of cobalt sulfate.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/05//
VL  - 49
IS  - 1
M3  - Article
SP  - 56
EP  - 67
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Cobalt sulfate is a water-soluble cobalt salt with a variety of industrial and agricultural uses. Several cobalt compounds have induced sarcomas at injection sites in animals, and reports have suggested that exposure to cobalt-containing materials may cause lung cancer in humans. The present studies were done because no adequate rodent carcinogenicity studies had been performed with a soluble cobalt salt using a route relevant to occupational exposures. Groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to aerosols containing 0, 0.3, 1.0, or 3.0 mg/m3 cobalt sulfate hexahydrate, 6 h/day, 5 days/week, for 104 weeks. Survival and body weights of exposed rats and mice were generally unaffected by the exposures. In rats, proteinosis, alveolar epithelial metaplasia, granulomatous alveolar inflammation, and interstitial fibrosis were observed in the lung in all exposed groups. Nonneoplastic lesions of the nose and larynx were also attributed to exposure to all concentrations of cobalt sulfate. In 3.0 mg/m3 male rats and in female rats exposed to 1.0 or 3.0 mg/m3, the incidences of alveolar/bronchiolar neoplasms were increased over those in the control groups. Lung tumors occurred with significant positive trends in both sexes. the incidences of adrenal pheochromocytoma in 1.0 mg/m3 male rats and in 3.0 mg/m3 female rats were increased. Nonneoplastic lesions of the respiratory tract were less severe in mice than in rats. In mice, alveolar/bronchiolar neoplasms in 3.0 mg/m3 males and females were greater than those in the controls, and lung tumors occurred with significantly positive trends. Male mice had liver lesions consistent with a Helicobacter hepaticus infection. Incidences of liver hemangiosarcomas were increased in exposed groups of male mice; however, because of the infection, no conclusion could be reached concerning an association between liver hemangiosarcomas and cobalt sulfate. In summary, exposure to cobalt sulfate by inhalation resulted in increased incidence of alveolar/bronchiolar neoplasms and a spectrum of inflammatory, fibrotic, and proliferative lesions in the respiratory tracts of male and female rats and mice. Adrenal pheochromocytomas were increased in female rats, and possibly in male rats. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cobalt sulfate
KW  - Carcinogenicity testing
KW  - Mice
KW  - Rats
KW  - Pheochromocytoma
KW  - adrenal pheochromocytomas
KW  - alveolar/bronchiolar neoplasms
KW  - B6C3F1 mice
KW  - B6C3F1 mice
KW  - carcinogenesis
KW  - cobalt sulfate
KW  - F344 rats
KW  - F344 rats.
KW  - inhalation
KW  - respiratory toxicant
N1  - Accession Number: 44405755; Bucher, John R. 1; Email Address: bucher@niehs.nih.gov; Hailey, J. R. 1; Roycroft, Joseph R. 1; Haseman, Joseph K. 1; Sills, Robert C. 1; Grumbein, S. L. 2; Mellick, P. W. 2; Chou, B. J. 2; Affiliations: 1: National Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709; 2: Battelle Pacific Northwest Laboratories, Richland, Washington 99352; Issue Info: May1999, Vol. 49 Issue 1, p56; Thesaurus Term: Cobalt sulfate; Thesaurus Term: Carcinogenicity testing; Thesaurus Term: Mice; Subject Term: Rats; Subject Term: Pheochromocytoma; Author-Supplied Keyword: adrenal pheochromocytomas; Author-Supplied Keyword: alveolar/bronchiolar neoplasms; Author-Supplied Keyword: B6C3F1 mice; Author-Supplied Keyword: B6C3F1 mice; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: cobalt sulfate; Author-Supplied Keyword: F344 rats; Author-Supplied Keyword: F344 rats.; Author-Supplied Keyword: inhalation; Author-Supplied Keyword: respiratory toxicant; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Illustrations: 6 Black and White Photographs, 6 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Lewis, James G.
AU  - Graham, Doyle G.
AU  - Valentine, William M.
AU  - Morris, Richard W.
AU  - Morgan, Daniel L.
AU  - Sills, Robert C.
T1  - Exposure of C57BL/6 mice to carbon disulfide induces early lesions of atherosclerosis and enhances arterial fatty deposits induced by a high fat diet.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/05//
VL  - 49
IS  - 1
M3  - Article
SP  - 124
EP  - 132
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Even though atherosclerotic cardiovascular disease (ACVD) is the number one cause of death in the United States, the effects of environmental toxicants on this process are less well studied than the effects of chemicals on the second leading cause of death, cancer. There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) have increased rates of ACVD, and there is conflicting evidence of the atherogenic potential of CS2 from animal studies. Chemical modification, such as oxidation of low-density lipoproteins (LDL), is tightly associated with increased LDL uptake by macrophages and the development of arterial fatty streaks. CS2 has been previously demonstrated to modify several proteins in vitro including LDL, and others in vivo through derivatization and covalent cross-linking. To investigate both the capacity of CS2 to induce arterial fatty deposit formation induced by a western style, high fat diet, groups of 20 female C57BL/6 mice were exposed to 0, 50, 500, or 800 ppm CS2 by inhalation. Half the animals in each group were placed on an atherogenic high fat diet and half on a control diet (NIH-07). Animals were sacrificed after 1, 4, 8, 12, 16 or 20 weeks of exposure, and the rates of fatty deposit formation under the aortic valve leaflets were evaluated. Exposure of mice on the control diet to 500 and 800 ppm CS2 induced a small but significant increase in the rate of fatty deposit formation over non-exposed controls. A more striking result was observed in the animals on the high fat diet. There was marked enhancement of the rate of fatty deposit formation in mice exposed to 500 and 800 ppm over the animals on the high fat diet alone. In addition, there was a small but significant enhancement in mice exposed to 50 ppm over the rate of fatty deposit formation induced by the high fat diet alone. Analysis of erythrocyte spectrin for protein cross-linking revealed a dose-dependent formation of α- and β-heterodimers in animals on both diets. These data demonstrate that CS2 is atherogenic at high concentrations, but more importantly, suggest that, in conjunction with other risk factors, CS2 at relatively low concentrations can enhance atherogenesis. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carbon disulfide
KW  - Atherosclerosis
KW  - Cardiovascular diseases
KW  - Macrophages
KW  - Arteries
KW  - and inhalation
KW  - and inhalation.
KW  - arterial fatty deposits
KW  - atherosclerosis
KW  - carbon disulfide
KW  - foam cells
KW  - high fat diet
KW  - spectrin
N1  - Accession Number: 44405763; Lewis, James G. 1; Email Address: lewis026@mc.duke.edu; Graham, Doyle G. 2; Valentine, William M. 2; Morris, Richard W. 3; Morgan, Daniel L. 4; Sills, Robert C. 4; Affiliations: 1: Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710; 2: Department of Pathology, Vanderbilt School of Medicine, Nashville, Tennessee 37232; 3: Analytical Sciences, Inc., Durham, North Carolina 27713; 4: Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: May1999, Vol. 49 Issue 1, p124; Thesaurus Term: Carbon disulfide; Subject Term: Atherosclerosis; Subject Term: Cardiovascular diseases; Subject Term: Macrophages; Subject Term: Arteries; Author-Supplied Keyword: and inhalation; Author-Supplied Keyword: and inhalation.; Author-Supplied Keyword: arterial fatty deposits; Author-Supplied Keyword: atherosclerosis; Author-Supplied Keyword: carbon disulfide; Author-Supplied Keyword: foam cells; Author-Supplied Keyword: high fat diet; Author-Supplied Keyword: spectrin; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 9p; Illustrations: 1 Color Photograph, 3 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-42595-019
AN  - 2015-42595-019
AU  - Ritter, Amy
AU  - Wenner, Peter
AU  - Ho, Stephen
AU  - Whelan, Patrick J.
AU  - O'Donovan, Michael J.
T1  - Activity patterns and synaptic organization of ventrally located interneurons in the embryonic chick spinal cord.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/05//
VL  - 19
IS  - 9
SP  - 3457
EP  - 3471
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - O'Donovan, Michael J., Laboratory of Neural Control, National Institutes of Health, Room 3A50, Building 49, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-42595-019. PMID: 10212306 Partial author list: First Author & Affiliation: Ritter, Amy; Section on Developmental Neurobiology, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ritter, Amy. Major Descriptor: Axons; Spinal Cord; Synapses; Interneurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 15. Issue Publication Date: May, 1999. Publication History: Accepted Date: Feb 9, 1999; Revised Date: Jan 12, 1999; First Submitted Date: Jul 27, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - To investigate the origin of spontaneous activity in developing spinal networks, we examined the activity patterns and synaptic organization of ventrally located lumbosacral interneurons, including those whose axons project into the ventrolateral funiculus (VLF), in embryonic day 9 (E9)–E12 chick embryos. During spontaneous episodes, rhythmic synaptic potentials were recorded from the VLF and from spinal interneurons that were synchronized, cycle by cycle, with rhythmic ventral root potentials. At the beginning of an episode, ventral root potentials started before the VLF discharge and the firing of individual interneurons. However, pharmacological blockade of recurrent motoneuron collaterals did not prevent or substantially delay interneuron recruitment during spontaneous episodes. The synaptic connections of interneurons were examined by stimulating the VLF and recording the potentials evoked in the ventral roots, in the VLF, or in individual interneurons. Low-intensity stimulation of the VLF evoked a short-latency depolarizing potential in the ventral roots, or in interneurons, that was probably mediated mono- or disynaptically. At higher intensities, long-latency responses were recruited in a highly nonlinear manner, eventually culminating in the activation of an episode. VLF-evoked potentials were reversibly blocked by extracellular Co2+, indicating that they were mediated by chemical synaptic transmission. Collectively, these findings indicate that ventral interneurons are rhythmically active, project to motoneurons, and are likely to be interconnected by recurrent excitatory synaptic connections. This pattern of organization may explain the synchronous activation of spinal neurons and the regenerative activation of spinal networks when provided with a suprathreshold stimulus. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - spinal cord
KW  - rhythmic activity
KW  - interneurons
KW  - development
KW  - synchrony
KW  - chick
KW  - 1999
KW  - Axons
KW  - Spinal Cord
KW  - Synapses
KW  - Interneurons
KW  - 1999
U1  - Sponsor: National Institutes of Health, US. Other Details: National Research Service Award. Recipients: Ritter, Amy
U1  - Sponsor: Natural Sciences and Engineering Research Council, Canada. Other Details: Fellowship. Recipients: Whelan, Patrick J.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42595-024
AN  - 2015-42595-024
AU  - Rios, Maribel
AU  - Habecker, Beth
AU  - Sasaoka, Toshikuni
AU  - Eisenhofer, Graeme
AU  - Tian, Hua
AU  - Landis, Story
AU  - Chikaraishi, Dona
AU  - Roffler-Tarlov, Suzanne
T1  - Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/05//
VL  - 19
IS  - 9
SP  - 3519
EP  - 3526
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Roffler-Tarlov, Suzanne, 136 Harrison Avenue, Boston, MA, US, 02111
N1  - Accession Number: 2015-42595-024. PMID: 10212311 Partial author list: First Author & Affiliation: Rios, Maribel; Department of Neuroscience, Tufts University Medical School, Boston, MA, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Catecholamines; DOPA; Hydroxylases; Tyrosine. Minor Descriptor: Levodopa; Mice. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: May, 1999. Publication History: Accepted Date: Feb 18, 1999; Revised Date: Jan 25, 1999; First Submitted Date: Sep 30, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Catecholamine neurotransmitters are synthesized by hydroxylation of tyrosine to L-dihydroxyphenylalanine (L-Dopa) by tyrosine hydroxylase (TH). The elimination of TH in both pigmented and albino mice described here, like pigmented TH-null mice reported previously (Kobayashi et al., 1995; Zhou et al., 1995), demonstrates the unequivocal requirement for catecholamines during embryonic development. Although the lack of TH is fatal, TH-null embryos can be rescued by administration of catecholamine precursors to pregnant dams. Once born, TH-null pups can survive without further treatment until weaning. Given the relatively rapid half-life of catecholamines, we expected to find none in postnatal TH-null pups. Despite the fact that the TH-null pups lack TH and have not been supplemented with catecholamine precursers, catecholamines are readily detected in our pigmented line of TH-null mice by glyoxylic acid-induced histofluorescence at postnatal day 7 (P7) and P15 and quantitatively at P15 in sympathetically innervated peripheral organs, in sympathetic ganglia, in adrenal glands, and in brains. Between 2 and 22% of wild-type catecholamine concentrations are found in these tissues in mutant pigmented mice. To ascertain the source of the catecholamine, we examined postnatal TH-null albino mice that lack tyrosinase, another enzyme that converts tyrosine to L-Dopa but does so during melanin synthesis. In contrast to the pigmented TH-null mice, catecholamine histofluorescence is undetectable in postnatal albino mutants, and the catecholamine content of TH-null pups lacking tyrosinase is 18% or less than that of TH-null mice with tyrosinase. Thus, these extraordinary circumstances reveal that tyrosinase serves as an alternative pathway to supply catecholamines. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - catecholamines
KW  - tyrosine hydroxylase-null mutation
KW  - tyrosinase
KW  - tyrosine hydroxylase
KW  - tyrosinase and catecholamine synthesis
KW  - catecholamines in development
KW  - catecholamine synthesis
KW  - 1999
KW  - Catecholamines
KW  - DOPA
KW  - Hydroxylases
KW  - Tyrosine
KW  - Levodopa
KW  - Mice
KW  - 1999
U1  - Sponsor: National Institutes of Health, US. Grant: NS 31673. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, Intramural Program, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42596-030
AN  - 2015-42596-030
AU  - Roche, Katherine W.
AU  - Ly, C. Dune
AU  - Petralia, Ronald S.
AU  - Wang, Ya-Xian
AU  - McGee, Aaron W.
AU  - Bredt, David S.
AU  - Wenthold, Robert J.
T1  - Postsynaptic density-93 interacts with the δ2 glutamate receptor subunit at parallel fiber synapses.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/05//
VL  - 19
IS  - 10
SP  - 3926
EP  - 3934
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Roche, Katherine W., National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 36, Room 5D08, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-42596-030. PMID: 10234023 Partial author list: First Author & Affiliation: Roche, Katherine W.; Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Roche, Katherine W. Major Descriptor: Cerebellum; Glutamate Receptors; Neural Receptors; Purkinje Cells. Minor Descriptor: Rats; Synapses. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: May, 1999. Publication History: Accepted Date: Feb 5, 1999; Revised Date: Feb 4, 1999; First Submitted Date: Dec 3, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - The glutamate receptor subunit δ2 has a unique distribution at the parallel fiber–Purkinje cell synapse of the cerebellum, which is developmentally regulated such that δ2 occurs at both parallel fiber synapses and climbing fiber synapses early in development but is restricted to parallel fiber synapses in adult animals. To identify proteins that might be involved in the trafficking or docking of δ2 receptors, we screened a yeast two-hybrid library with the cytosolic C terminus of δ2 and isolated a member of the postsynaptic density (PSD)-95 family of proteins, which are known to interact with the extreme C termini of NMDA receptors. We find that δ2 binds specifically to PSD-93, which is enriched in Purkinje cells. In addition, PSD-93 clusters δ2 when they are coexpressed in heterologous cells, and clustering is disrupted by point mutations of δ2 that disrupt the δ2–PSD-93 interaction. Ultrastructural localization of PSD-93 and δ2 shows they are colocalized at parallel fiber synapses; however, PSD-93 also is present at climbing fiber synapses of the adult rat, where δ2 is not found, indicating that the presence of PSD-93 alone is not sufficient for determining the synaptic expression of δ2. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptor
KW  - receptor targeting
KW  - yeast two-hybrid
KW  - synaptic anchor
KW  - cerebellum
KW  - synaptic receptor regulation
KW  - 1999
KW  - Cerebellum
KW  - Glutamate Receptors
KW  - Neural Receptors
KW  - Purkinje Cells
KW  - Rats
KW  - Synapses
KW  - 1999
U1  - Sponsor: National Institutes of Health, National Institute of General Medical Sciences, PRAT Program, US. Other Details: Pharmacology Research Associate Program. Recipients: Roche, Katherine W.
U1  - Sponsor: National Institute on Deafness and Other Communication Disorders, Intramural Program, US. Recipients: Wenthold, Robert J.
U1  - Sponsor: National Association for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1  - Sponsor: National Institutes of Health, US. Grant: GM36017. Recipients: Bredt, David S.
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UR  - rochek@nidcd.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42596-032
AN  - 2015-42596-032
AU  - Qin, Zheng-Hong
AU  - Chen, Ren-Wu
AU  - Wang, Yumei
AU  - Nakai, Masami
AU  - Chuang, De-Maw
AU  - Chase, Thomas N.
T1  - Nuclear factor κB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/05//
VL  - 19
IS  - 10
SP  - 4023
EP  - 4033
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Chase, Thomas N., Experimental Therapeutics Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 10, Room 5C103, 10 Center Drive, MSC 1406, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-42596-032. PMID: 10234031 Partial author list: First Author & Affiliation: Qin, Zheng-Hong; Experimental Therapeutics Branch, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gene Expression; N-Methyl-D-Aspartate; Visual Cortex; Transcription Factors. Minor Descriptor: Rats; Striatum; Neuroprotection. Classification: Genetics (2510). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: May, 1999. Publication History: Accepted Date: Mar 9, 1999; Revised Date: Mar 1, 1999; First Submitted Date: Dec 16, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Nuclear factor κB (NF-κB) appears to participate in the excitotoxin-induced apoptosis of striatal medium spiny neurons. To elucidate molecular mechanisms by which this transcription factor contributes to NMDA receptor-triggered apoptotic cascades in vivo, rats were given the NMDA receptor agonist quinolinic acid (QA) by intrastriatal infusion, and the role of NF-κB in the induction of apoptosis-related genes and gene products was evaluated. QA administration induced time-dependent NF-κB nuclear translocation. The nuclear NF-κB protein after QA treatment was comprised mainly of p65 and c-Rel subunits as detected by gel supershift assay. Levels of c-Myc and p53 mRNA and protein were markedly increased at the time of QA-induced NF-κB nuclear translocation. Immunohistochemical analysis showed that c-Myc and p53 induction occurred in the excitotoxin-sensitive medium-sized striatal neurons. NF-κB nuclear translocation was blocked in a dose-dependent manner by the cell-permeable recombinant peptide NF-κB SN50, but not by the NF-κB SN50 control peptide. NF-κB SN50 significantly inhibited the QA-induced elevation in levels of c-Myc and p53 mRNA and protein. Pretreatment or posttreatment with NF-κB SN50, but not the control peptide, also substantially reduced the intensity of QA-induced internucleosomal DNA fragmentation. The results suggest that NF-κB may promote an apoptotic response in striatal medium-sized neurons to excitotoxic insult through upregulation of c-Myc and p53. This study also provides evidence indicating an unique signaling pathway from the cytoplasm to the nucleus, which regulates p53 and c-Myc levels in these neurons during apoptosis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - transcription factor
KW  - NF-kB
KW  - quinolinic acid
KW  - tumor suppressor gene
KW  - apoptosis
KW  - Huntington’s disease
KW  - 1999
KW  - Gene Expression
KW  - N-Methyl-D-Aspartate
KW  - Visual Cortex
KW  - Transcription Factors
KW  - Rats
KW  - Striatum
KW  - Neuroprotection
KW  - 1999
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107220596
T1  - Type 2 diabetes among the Pima Indians of Arizona: an epidemic attributable to environmental change?...Second Nestle Conference on Nutrition: Nutrition-Gene Interactions in Human Populations: the Amerindian Case, Mexico City, Mexico, January 29-30, 1998
AU  - Bennett PH
Y1  - 1999/05/02/May99 Part 2 of 2
N1  - Accession Number: 107220596. Language: English. Entry Date: 19991101. Revision Date: 20150820. Publication Type: Journal Article; commentary; response; review; tables/charts. Supplement Title: May99 Part 2 of 2. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405. 
KW  - Diabetes Mellitus, Type 2
KW  - Diabetes Mellitus, Type 2 -- Familial and Genetic
KW  - Native Americans -- History -- Arizona
KW  - Life Style
KW  - Genetics
KW  - Arizona
KW  - Diabetes Mellitus, Type 2 -- Epidemiology
KW  - Diabetes Mellitus, Type 2 -- Ethical Issues
KW  - Diabetes Mellitus, Type 2 -- History
KW  - Risk Factors
KW  - Birth Weight
KW  - Pregnancy in Diabetes
KW  - Infant, Newborn
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Pregnancy
KW  - Male
KW  - Female
KW  - Fetus
SP  - S51
EP  - 4
JO  - Nutrition Reviews
JF  - Nutrition Reviews
JA  - NUTR REV
VL  - 57
IS  - 5
PB  - Oxford University Press / USA
SN  - 0029-6643
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 E Indian School Rd, Phoenix, Arizona 85014
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107213744
T1  - NIH conference: adrenocortical tumors: recent advances in basic concepts and clinical management.
AU  - Bornstein SR
AU  - Stratakis CA
AU  - Chrousos GP
Y1  - 1999/05/04/
N1  - Accession Number: 107213744. Language: English. Entry Date: 19991001. Revision Date: 20150711. Publication Type: Journal Article; algorithm; diagnostic images; pictorial; review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Grants from Mildred Scheel Stiftung (10-1070-Re I) and by a Heisenberg grant (DFG BO 1141/6-1). NLM UID: 0372351. 
KW  - Adrenal Gland Neoplasms
KW  - Funding Source
SP  - 759
EP  - 771
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 130
IS  - 9
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 0003-4819
AD  - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Room 10N 262, 10 Center Dr, MSC 1862, Bethesda, MD 20892-1862; e-mail: bornstes@ccl.nichd.nih.gov
U2  - PMID: 10357696.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Chow, Wong-Ho
AU  - Devesa, Susan S.
AU  - Chow, W H
AU  - Devesa, S S
AU  - Warren, J L
AU  - Fraumeni, J F Jr
T1  - Rising incidence of renal cell cancer in the United States.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/05/05/
VL  - 281
IS  - 17
M3  - journal article
SP  - 1628
EP  - 1631
SN  - 00987484
AB  - <bold>Context: </bold>Clinical surveys have revealed that incidental detection of renal cell carcinoma is rising because of increased use of imaging procedures.<bold>Objective: </bold>To examine incidence, mortality, and survival trends of renal cell and renal pelvis cancers by age, sex, race, and tumor stage at diagnosis.<bold>Design: </bold>Calculation of age-adjusted incidence and mortality rates, along with 5-year relative survival rates, using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program.<bold>Setting and Participants: </bold>Patients diagnosed as having kidney cancer from 1975 through 1995 in the 9 geographic areas covered by tumor registries in the SEER program, which represent about 10% of the US population.<bold>Main Outcome Measures: </bold>Incidence, mortality, and 5-year relative survival rates by time periods.<bold>Results: </bold>The age-adjusted incidence rates for renal cell carcinoma between 1975 and 1995 for white men, white women, black men, and black women were 9.6, 4.4, 11.1, and 4.9 per 100000 person-years, respectively. The corresponding rates for renal pelvis cancer were 1.5, 0.7, 0.8, and 0.5 per 100000 person-years. Renal cell cancer incidence rates increased steadily between 1975 and 1995, by 2.3% annually among white men, 3.1 % among white women, 3.9% among black men, and 4.3% among black women. Increases were greatest for localized tumors but were also seen for more advanced and unstaged tumors. In contrast, the incidence rates for renal pelvis cancer declined among white men and remained stable among white women and blacks. Although 5-year relative survival rates for patients with renal cell cancer improved among whites but not among blacks, kidney cancer mortality rates increased in all race and sex groups.<bold>Conclusions: </bold>Increasing detection of presymptomatic tumors by imaging procedures, such as ultrasonography, computed tomography, and magnetic resonance imaging, does not fully explain the upward incidence trends of renal cell carcinoma. Other factors may be contributing to the rapidly increasing incidence of renal cell cancer in the United States, particularly among blacks. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - KIDNEYS -- Cancer
KW  - PELVIS
KW  - CANCER
KW  - MEDICAL statistics
KW  - RENAL cell carcinoma
KW  - STATISTICS
N1  - Accession Number: 1818179; Chow, Wong-Ho Devesa, Susan S. Chow, W H 1 Devesa, S S Warren, J L Fraumeni, J F Jr; Affiliation:  1: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA; Source Info: 5/5/99, Vol. 281 Issue 17, p1628; Subject Term: KIDNEYS -- Cancer; Subject Term: PELVIS; Subject Term: CANCER; Subject Term: MEDICAL statistics; Subject Term: RENAL cell carcinoma; Subject Term: STATISTICS; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Fananapazir, Lameh
AU  - Fananapazir, L
T1  - Advances in molecular genetics and management of hypertrophic cardiomyopathy.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/05/12/
VL  - 281
IS  - 18
M3  - journal article
SP  - 1746
EP  - 1752
SN  - 00987484
AB  - Presents the case of a woman diagnosed with obstructive hypertrophic cardiomyopathy (HCM).  Phenotypic heterogeneity, a notable feature of HCM; Clinical correlates of genetic defects; Cardiac hypertrophy as a compensatory mechanism; Theoretical strategies to induce regression of cardiac disease; Risk evaluation and mechanisms of sudden death; Management of arrhythmias; Management of obstructive HCM.
KW  - CARDIAC hypertrophy
KW  - HEART diseases
KW  - ARRHYTHMIA
KW  - PHENOTYPE
KW  - GENETIC disorders
N1  - Accession Number: 1851542; Fananapazir, Lameh Fananapazir, L 1; Affiliation:  1: Section of Clinical Electrophysiology and Inherited Cardiac Diseases, Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1650, USA; Source Info: 5/12/99, Vol. 281 Issue 18, p1746; Subject Term: CARDIAC hypertrophy; Subject Term: HEART diseases; Subject Term: ARRHYTHMIA; Subject Term: PHENOTYPE; Subject Term: GENETIC disorders; Number of Pages: 7p; Illustrations: 3 Black and White Photographs, 1 Diagram, 3 Charts; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107150602
T1  - Dietary factors and the risk of gastric cancer in Mexico City.
AU  - Ward MH
AU  - López-Carrillo L
Y1  - 1999/05/15/1999 May 15
N1  - Accession Number: 107150602. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Supported by the Mexican Ministry of Health, the National Council of Science and Technology (Mexico), the Mexican Health Foundation, and the Advisory Board in Epidemiology (Mexico). NLM UID: 7910653. 
KW  - Diet
KW  - Stomach Neoplasms -- Epidemiology
KW  - Stomach Neoplasms -- Etiology
KW  - Mexico
KW  - Case Control Studies
KW  - Interviews
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Logistic Regression
KW  - Meat -- Adverse Effects
KW  - Vegetables
KW  - Fruit
KW  - Dairy Products -- Adverse Effects
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 925
EP  - 932
JO  - American Journal of Epidemiology
JF  - American Journal of Epidemiology
JA  - AM J EPIDEMIOL
VL  - 149
IS  - 10
PB  - Oxford University Press / USA
AB  - Dietary factors play an important role in gastric cancer risk but have not been investigated extensively in Mexico. The authors conducted a population-based case-control study of gastric cancer in the Mexico City, Mexico, metropolitan area in 1989-1990. A total of 220 patients with histologically confirmed gastric adenocarcinomas were interviewed. Controls were an age-stratified random sample of residents of the Mexico City metropolitan area. The dietary questionnaire was a 70-item semiquantitative food frequency adapted for the Mexican diet. Odds ratios were calculated for quartiles of consumption of food groups and were adjusted for age, gender, calories, chili pepper intake, cigarette smoking, socioeconomic status, added salt, and history of peptic ulcer disease. There was approximately a threefold increased risk of gastric cancer for frequent consumption (highest quartile) of both fresh meat (odds ratio (OR) = 3.1) and processed meat (OR = 3.2). Odds ratios were also significantly elevated for frequent consumption of dairy products (OR = 2.7) and fish (OR = 2.2). The authors observed a decreasing gradient of risk with increasing frequency of vegetable consumption due to a significant inverse trend for the yellow and orange vegetables. High intake of citrus fruits showed a slight inverse association. Consumption of salty snacks more than twice per month was associated with an 80 percent increased risk, and there was a significant positive trend. These findings are consistent with many studies around the world that indicate important roles for salt, processed meats, and vegetable consumption in gastric cancer risk.
SN  - 0002-9262
AD  - Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
U2  - PMID: 10342801.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Shibata, Masa-Aki
AU  - Min-Ling Liu
AU  - Knudson, Michael C.
AU  - Shibata, Eiko
AU  - Yoshidome, Katsuhide
AU  - Bandey, Tabassum
AU  - Korsmeyer, Stanley J.
AU  - Green, Jeffrey E.
T1  - Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/05/17/
VL  - 18
IS  - 10
M3  - Article
SP  - 2692
EP  - 2701
SN  - 02614189
AB  - The dramatic increase in apoptosis observed during the development of preneoplastic mammary lesions is associated with a significant elevation in Bax expression in C3(1)/SV40 large T antigen (TAg) transgenic mice. The significance of Bax expression during tumor progression in vivo was studied by generating doubletransgenic mice carrying the C3(1)/TAg transgene and mutant alleles for bax. C3(1)/TAg transgenic mice carrying mutant bax alleles exhibited accelerated rates of tumor growth, increased tumor numbers, larger tumor mass and decreased survival rates compared with mice carrying wild-type bax. Accelerated tumorigenesis associated with the bax+/- genotype did not require the loss of function of the second bax allele. Thus, haploid insufficiency of bax is enough to accelerate tumor progression, suggesting that the protective effect of Bax is dose-dependent. While levels of apoptosis in the preneoplastic lesions, but not carcinomas, were reduced in bax+/- or bax-/- mice compared with bax+/+ mice, rates of cellular proliferation in mammary lesions were similar among all bax genotypes. These data demonstrate that bax is a critical suppressor of mammary tumor progression at the stage of preneoplastic mammary lesion development through the upregulation of apoptosis, but that this protective effect is lost during the transition from preneoplasia to invasive carcinoma. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APOPTOSIS
KW  - ANTIGENS
KW  - TUMORS
KW  - TUMORS -- Growth
KW  - HAPLOIDY
KW  - GENETICS
KW  - apoptosis
KW  - bax
KW  - cell death
KW  - mammary gland
KW  - transgenic mice
KW  - tumor progression
N1  - Accession Number: 13004076; Shibata, Masa-Aki 1 Min-Ling Liu 1 Knudson, Michael C. 2 Shibata, Eiko 1 Yoshidome, Katsuhide 1 Bandey, Tabassum 3 Korsmeyer, Stanley J. 2 Green, Jeffrey E. 1; Email Address: JEGreen@nih.gov; Affiliation:  1: Laboratory of Cell Regulation and Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institute of Health, Bethesda, MD, USA  2: Diana-Farber Cancer Institute, Harvard University, Boston, MA, USA  3: Science Applications International Corporation, Frederick, MD, USA; Source Info: 5/17/99, Vol. 18 Issue 10, p2692; Subject Term: APOPTOSIS; Subject Term: ANTIGENS; Subject Term: TUMORS; Subject Term: TUMORS -- Growth; Subject Term: HAPLOIDY; Subject Term: GENETICS; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: bax; Author-Supplied Keyword: cell death; Author-Supplied Keyword: mammary gland; Author-Supplied Keyword: transgenic mice; Author-Supplied Keyword: tumor progression; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/18.10.2692
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Emanuel, Ezekiel J.
T1  - Death's Door.
JO  - New Republic
JF  - New Republic
Y1  - 1999/05/17/
VL  - 220
IS  - 20
M3  - Article
SP  - 15
EP  - 16
PB  - TNR II, LLC
SN  - 00286583
AB  - Discusses Euthanasia and assisted suicide in the United States in the wake of the March 1999 conviction and sentencing of advocate Jack Kevorkian on second-degree murder charges. Articulation of the argument supporting the practices; Account of the U.S. legislation related to Euthanasia; Public opinion and evidence of declining support for Euthanasia; Attitude within the medical profession regarding Euthanasia.
KW  - EUTHANASIA
KW  - ASSISTED suicide
KW  - MEDICAL laws & legislation
KW  - MEDICAL ethics
KW  - PUBLIC opinion
KW  - ATTITUDE (Psychology)
KW  - SOCIAL policy
KW  - 1993-
KW  - UNITED States
N1  - Accession Number: 1815020; Emanuel, Ezekiel J. 1; Affiliation:  1: Oncologist and Chief, Department of the Clinical Center, National Institutes of Health.; Source Info: 05/17/99, Vol. 220 Issue 20, p15; Subject Term: EUTHANASIA; Subject Term: ASSISTED suicide; Subject Term: MEDICAL laws & legislation; Subject Term: MEDICAL ethics; Subject Term: PUBLIC opinion; Subject Term: ATTITUDE (Psychology); Subject Term: SOCIAL policy; Subject Term: 1993-; Subject Term: UNITED States; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 2p; Illustrations: 1 Black and White Photograph; Document Type: Article; Full Text Word Count: 1424
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107127790
T1  - Alcoholism treatment in the United States: an overview.
AU  - Fuller RK
AU  - Hiller-Sturmhöfel S
Y1  - 1999/06//
N1  - Accession Number: 107127790. Language: English. Entry Date: 20000801. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100900708. 
KW  - Alcoholism -- Therapy -- United States
KW  - Substance Use Rehabilitation Programs
KW  - Psychotherapy
KW  - United States
KW  - Alcohol Withdrawal Delirium -- Prevention and Control
KW  - Alcoholism -- Drug Therapy
KW  - Primary Health Care
KW  - Human
SP  - 69
EP  - 77
JO  - Alcohol Research & Health
JF  - Alcohol Research & Health
JA  - ALCOHOL RES HEALTH
VL  - 23
IS  - 2
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - On any given day, more than 700,000 people in the United States receive alcoholism treatment in either inpatient or outpatient settings. For many of those patients, detoxification--with or without pharmacotherapy--is the first step of treatment. The major behavioral approaches currently used in alcoholism treatment include cognitive-behavioral therapy, motivational enhancement therapy, and Alcoholics Anonymous (AA) or related 12-step programs. Clinical studies, such as the Project MATCH trial, have compared the effectiveness of these approaches. Overall, that study detected no significant differences among the three treatments in patient outcome, although certain treatment methodologies may be most appropriate for patients with certain characteristics. Pharmacotherapy with aversive or anticraving medications may supplement behavioral treatment approaches. Brief interventions that are delivered by primary health care providers also have been shown to reduce drinking levels, particularly in nondependent drinkers.
SN  - 1535-7414
AD  - Director, Division of Clinical and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
U2  - PMID: 10890799.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Malcoe, Lorraine Halinka
AU  - Shaw, Gary M.
AU  - Lammer, Edward J.
AU  - Herman, Allen A.
T1  - The Effect of Congenital Anomalies on Mortality Risk in White and Black Infants.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/06//
VL  - 89
IS  - 6
M3  - Article
SP  - 887
EP  - 892
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This population-based study examined the effect of all major congenital anomalies on the mortality of White and Black infants by infant sex, birthweight, gestational age, and lethality of the anomaly. The study also determined the total contribution of anomalies to infant mortality. Methods. California Birth Defects Monitoring Program data were merged with linked birth-death files for 278 646 singleton non-Hispanic White and Black infants born in 1983 through 1986. Malformed infants were compared with nonmalformed infants to determine the effect of anomalies on mortality. Results. The presence of any congenital anomaly increased mortality 9.0-fold (95% CI = 7.3, 11.1) for Black infants and 17.8-fold (95% CI = 16.2, 19.6) for White infants. Even "non-lethal" anomalies increased mortality up to 8.9-fold. Overall, anomalies contributed to 33% of White infant deaths, to 19% of Black infant deaths, and to over 60% of deaths among Black and White neonates weighing over 1499 g. Conclusions. The contribution of congenital anomalies to mortality of both low- (<2500 g) and normal-birth-weight infants is substantially higher than previously estimated, representing a large public health problem for both Black and White infants. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HUMAN abnormalities
KW  - MORTALITY
KW  - NEWBORN infants -- Death
KW  - BIRTH weight
KW  - GESTATIONAL age
KW  - CALIFORNIA
N1  - Accession Number: 1907214; Malcoe, Lorraine Halinka 1; Email Address: lorraine-malcoe@ouhsc.edu Shaw, Gary M. 1 Lammer, Edward J. 2 Herman, Allen A. 3; Affiliation:  1: California Birth Defects Monitoring Program, Emeryville  2: Division of Medical Genetics, Children's Hospital, Oakland, Calif.  3: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Md.; Source Info: Jun99, Vol. 89 Issue 6, p887; Subject Term: HUMAN abnormalities; Subject Term: MORTALITY; Subject Term: NEWBORN infants -- Death; Subject Term: BIRTH weight; Subject Term: GESTATIONAL age; Subject Term: CALIFORNIA; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 4657
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Schwartz, Marc D.
AU  - Rimer, Barbara K.
AU  - Daly, Mary
AU  - Sands, Colleen
AU  - Lerman, Caryn
T1  - A Randomized Trial of Breast Cancer Risk Counseling: The Impact on Self-Reported Mammography Use.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/06//
VL  - 89
IS  - 6
M3  - Article
SP  - 924
EP  - 926
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. We evaluated the impact of individualized breast cancer risk counseling on mammography use among women at risk for breast cancer. Methods. Participants (n = 508) were randomized to the breast cancer risk counseling intervention or a general health education control intervention, and 85% completed follow-up. Results. In multivariate modeling, a significant group-by-education interaction demonstrated that among less-educated participants, breast, cancer risk counseling led to reduced mammography use. There was no intervention effect among the more-educated participants. Conclusions. These results suggest that standard breast cancer risk counseling could have an adverse impact on the health behaviors of less-educated women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BREAST cancer
KW  - MAMMOGRAMS
KW  - COUNSELING
KW  - HEALTH education
KW  - ATTITUDES toward health
KW  - MULTIVARIATE analysis
N1  - Accession Number: 1907223; Schwartz, Marc D. 1; Email Address: schwartm@gunet.georgetown.edu Rimer, Barbara K. 2 Daly, Mary 3 Sands, Colleen 3 Lerman, Caryn 1; Affiliation:  1: Lombardi Cancer Center, Georgetown University  Medical Center, Washington, DC  2: National Cancer Institute, Bethesda, Md.  3: Fox Chase Cancer Center, Philadelphia, Pa.; Source Info: Jun99, Vol. 89 Issue 6, p924; Subject Term: BREAST cancer; Subject Term: MAMMOGRAMS; Subject Term: COUNSELING; Subject Term: HEALTH education; Subject Term: ATTITUDES toward health; Subject Term: MULTIVARIATE analysis; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 2208
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pahor, Marco
AU  - Guralnik, Jack M.
AU  - Wan, Jim Y.
AU  - Ferrucci, Luigi
AU  - Penninx, Brenda W. J. H.
AU  - Lyles, Alan
AU  - Ling, Shari
AU  - Fried, Linda P.
T1  - Lower Body Osteoarticular Pain and Dose of Analgesic Medications in Older Disabled Women: The Women's Health and Aging Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/06//
VL  - 89
IS  - 6
M3  - Article
SP  - 930
EP  - 934
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study assessed use and dosage of analgesic medications in relation to severity of osteoarticular pain. Methods. The type and dose of analgesic medication and the severity of pain in the lower back, hips, knees, or feet of 1002 older disabled women were assessed. Results. Severe pain and the use of analgesic medications were reported by 48.5% and 78.8% of women, respectively. Among those who had severe pain, 41.2% were using less than 20% of the maximum analgesic dose. Overall, 6.6% of women were using more than 100% of the maximum dose. Conclusions. Severe pain is common. Additional, more effective, and safe analgesic treatments are needed for controlling pain in older persons. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ANALGESICS
KW  - DRUGS
KW  - PEOPLE with disabilities
KW  - PAIN management
KW  - DRUGS -- Effectiveness
KW  - THERAPEUTICS
N1  - Accession Number: 1907225; Pahor, Marco 1; Email Address: mpahor@utmem1.utmem.edu Guralnik, Jack M. 2 Wan, Jim Y. 1 Ferrucci, Luigi 3 Penninx, Brenda W. J. H. 4 Lyles, Alan 5 Ling, Shari 5 Fried, Linda P. 5; Affiliation:  1: Department of Preventive Medicine, University of Tennessee, Memphis  2: Epidemiology, Demography and Biometry Program, National  Institute on Aging, Bethesda, Md.  3: Geriatric Department, I Fraticini, Istituto Nazionale di  Ricerca e Cura per gli Anziani (INRCA), Florence, Italy  4: Institute for Research in Extramural Medicine, Vrije  Universiteit, Amsterdam, The Netherlands  5: Welch Center for Prevention, Epidemiology, and Clinical  Research, Johns Hopkins University, Baltimore, Md.; Source Info: Jun99, Vol. 89 Issue 6, p930; Subject Term: ANALGESICS; Subject Term: DRUGS; Subject Term: PEOPLE with disabilities; Subject Term: PAIN management; Subject Term: DRUGS -- Effectiveness; Subject Term: THERAPEUTICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 4871
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107219569
T1  - Recent advances in varicella-zoster virus infection.
AU  - Cohen JI
AU  - Brunell PA
AU  - Straus SE
AU  - Krause PR
AU  - Cohen, J I
AU  - Brunell, P A
AU  - Straus, S E
AU  - Krause, P R
Y1  - 1999/06//06/01/99
N1  - Accession Number: 107219569. Language: English. Entry Date: 19991001. Revision Date: 20161127. Publication Type: journal article; pictorial; review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351. 
KW  - Chickenpox
KW  - Herpes Zoster
SP  - 922
EP  - 932
JO  - Annals of Internal Medicine
JF  - Annals of Internal Medicine
JA  - ANN INTERN MED
VL  - 130
IS  - 11
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
AB  - Varicella-zoster virus has developed a complex strategy that allows it to remain latent in the body and avoid destruction by the immune system. Although varicella and zoster have been recognized since antiquity, several new clinical syndromes--including chronic chickenpox with persistent verrucous lesions and disseminated varicella without skin lesions--have been noted in patients with AIDS. Acyclovir has been the mainstay for treating severe varicella-zoster virus infections; however, newer antiviral agents, including valacyclovir and famciclovir, have expanded therapeutic options for treating adults with herpes zoster. The recently licensed live attenuated vaccine for varicella-zoster virus is effective in preventing chickenpox, and the vaccine's ability to stimulate immunity in seropositive adults suggests a promising strategy with which to modify the course of herpes zoster.
SN  - 0003-4819
AD  - Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1888, USA
AD  - Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Room 11N-228, Bethesda, MD 20892-1888
U2  - PMID: 10375341.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107209523
T1  - Laryngeal long latency response conditioning in abductor spasmodic dysphonia.
AU  - Deleyiannis FW
AU  - Gillespie M
AU  - Yamashita T
AU  - Bielamowicz S
AU  - Ludlow CL
Y1  - 1999/06//1999 Jun
N1  - Accession Number: 107209523. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts; tracings. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by the Division of Intramural Research, National Institutes of Health/National Institute on Deafness and Other Communication Disorders. NLM UID: 0407300. 
KW  - Conditioning (Psychology)
KW  - Laryngeal Muscles -- Physiopathology
KW  - Laryngeal Muscles -- Anatomy and Histology
KW  - Laryngeal Nerves -- Physiopathology
KW  - Reaction Time -- Physiology
KW  - Spasm -- Complications
KW  - Spasm -- Physiopathology
KW  - Voice Disorders -- Etiology
KW  - Voice Disorders -- Physiopathology
KW  - Funding Source
KW  - Electromyography
KW  - Supine Position
KW  - Speech Sample
KW  - Case Control Studies
KW  - Analysis of Variance
KW  - Two-Tailed Test
KW  - T-Tests
KW  - Algorithms
KW  - P-Value
KW  - Descriptive Statistics
KW  - Statistical Significance
KW  - Spasm -- Diagnosis
KW  - Phonetics
KW  - Laryngoscopy -- Methods
KW  - Fiber Optics -- Methods
KW  - Adult
KW  - Male
KW  - Female
KW  - Middle Age
KW  - Time Factors
KW  - Voice Disorders -- Diagnosis
KW  - Interrater Reliability
KW  - Human
SP  - 612
EP  - 619
JO  - Annals of Otology, Rhinology & Laryngology
JF  - Annals of Otology, Rhinology & Laryngology
JA  - ANN OTOL RHINOL LARYNGOL
VL  - 108
IS  - 6
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0003-4894
AD  - Voice and Speech Section, Division of Intramural Research, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland
U2  - PMID: 10378532.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Proschan, Michael A.
T1  - Miscellanea. Properties of spending function boundaries.
JO  - Biometrika
JF  - Biometrika
Y1  - 1999/06//
VL  - 86
IS  - 2
M3  - Article
SP  - 466
EP  - 473
SN  - 00063444
AB  - Clinical trials are monitored periodically for safety and efficacy, resulting in several 'looks' at interim data. If no account is taken of this, the type I error rate may be substantially higher than planned. One of the most popular methods of generating interim boundaries that result in an overall type I error rate of α is the spending function approach. This paper proves several properties of these boundaries, including a continuity-like property for looks occurring close to each other and a monotonicity property when additional looks are taken. How past monitoring affects future boundaries is also studied. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CLINICAL trials
KW  - CROSSOVER trials
KW  - ERROR rates
KW  - CLINICAL medicine
KW  - SAFETY
KW  - Clinical trial monitoring
KW  - Repeated significance testing
KW  - Repeated significance testing.
N1  - Accession Number: 44401025; Proschan, Michael A. 1; Email Address: ProschaM@gwgate.nhlbi.nih.gov; Affiliation:  1: National Heart, Lung and Blood Institute, II Rockledge Center, 6701 Rockledge Drive, MSC 7938, Bethesda,Maryland 20892-7938, U.S.A.; Source Info: Jun1999, Vol. 86 Issue 2, p466; Subject Term: CLINICAL trials; Subject Term: CROSSOVER trials; Subject Term: ERROR rates; Subject Term: CLINICAL medicine; Subject Term: SAFETY; Author-Supplied Keyword: Clinical trial monitoring; Author-Supplied Keyword: Repeated significance testing; Author-Supplied Keyword: Repeated significance testing.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gagné, Se
AU  - Larson, Mg
AU  - Pimstone, Sn
AU  - Schaefer, Ej
AU  - Kastelein, Jjp
AU  - Wilson, Pwf
AU  - Ordovas, Jm
AU  - Hayden, Mr
T1  - A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study.
JO  - Clinical Genetics
JF  - Clinical Genetics
Y1  - 1999/06//
VL  - 55
IS  - 6
M3  - Article
SP  - 450
EP  - 454
PB  - Wiley-Blackwell
SN  - 00099163
AB  - Genetic variation at the lipoprotein lipase (LPL) locus has been shown to influence plasma lipids and to modulate risk of coronary heart disease (CHD). Recently, we found that the most frequent variant at this locus, involving a C-terminal truncation of two amino acids (Ser447X), was associated with both higher LPL activity and high density lipoprotein cholesterol (HDL-C) in patients with CHD. However, the impact of this S447X variant on lipids and CHD in the general population was hitherto unknown. We, therefore, analyzed a total of 1 114 men and 1 144 women randomly ascertained from the Framingham Offspring Study (FOS) for the presence of this LPL variant. Carrier frequency of the S447X allele was 17%, and in men carrier status was associated with higher total cholesterol (Δ=6.2 mg/dl, p=0.03), higher HDL-C (Δ=2.3 mg/dl, p=0.01), and lower triglyceride (TG) levels (Δ=-19.4 mg/dl, p=0.02). Moreover, in men, the S447X allele conferred significant protection against CHD (odds ratio: 0.43; p=0.04). These effects on lipids and CHD were not seen in women. Our study represents the first report on the impact of this mutation on CHD in men from the general population, and we conclude, therefore, that the S447X variant may confer significant protection against high TG levels, low HDL-C, and premature CHD in these subjects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - LIPOPROTEIN lipase
KW  - CORONARY heart disease
KW  - HUMAN genetics -- Variation
KW  - coronary heart disease
KW  - gene
KW  - lipoprotein lipase
KW  - polymorphisms
N1  - Accession Number: 6085883; Gagné, Se 1 Larson, Mg 2 Pimstone, Sn 1 Schaefer, Ej 3 Kastelein, Jjp 4 Wilson, Pwf 5 Ordovas, Jm 3 Hayden, Mr 1; Affiliation:  1: Department of Medical Genetics, University of British Columbia, Vancouver, Canada,  2: Framingham Heart Study, Boston University, Framingham,  3: Lipid Metabolism Laboratory, US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA,  4: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands  5: Framingham Heart Study, National Heart, Lung and Blood Institute,; Source Info: Jun99, Vol. 55 Issue 6, p450; Subject Term: LIPOPROTEIN lipase; Subject Term: CORONARY heart disease; Subject Term: HUMAN genetics -- Variation; Author-Supplied Keyword: coronary heart disease; Author-Supplied Keyword: gene; Author-Supplied Keyword: lipoprotein lipase; Author-Supplied Keyword: polymorphisms; Number of Pages: 5p; Document Type: Article
L3  - 10.1034/j.1399-0004.1999.550609.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Woitach, J. T.
AU  - Hong, R.
AU  - Keck, C. L.
AU  - Zimonjic, D. B.
AU  - Popescu, N. C.
AU  - Thorgeirsson, S. S.
T1  - Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1--H1 and human chromosome 20p11.2 by fluorescence in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1999/06//
VL  - 85
IS  - 3/4
M3  - Article
SP  - 252
EP  - 253
SN  - 03010171
AB  - This article reveals the method of assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization. A full length cDNA clone was isolated by screening a mouse kidney cDNA library with a probe from the rat cDNA sequence. The mouse 1.9-kb cDNA fragment was used to isolate a bacterial artificial chromosome (BAC) clone containing the mouse Bog gene and the human Bog gene from their respective genomic libraries. The identification of the mouse and the human BAC clones was verified by partial DNA sequencing. Results at the end of the article indicate information regarding mapping data of mouse and human chromosomes.
KW  - HUMAN gene mapping
KW  - ANIMAL genome mapping
KW  - BACTERIAL artificial chromosomes
KW  - COMPLEMENTARY DNA
KW  - GENE libraries
KW  - FLUORESCENCE in situ hybridization
N1  - Accession Number: 12188156; Woitach, J. T. 1 Hong, R. 1 Keck, C. L. 1 Zimonjic, D. B. 1 Popescu, N. C. 1 Thorgeirsson, S. S. 1; Email Address: snorri_thorgeirsson@nih.gov; Affiliation:  1: Laboratory of Experimental Carcinogenesis, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, MD (USA).; Source Info: Jun99, Vol. 85 Issue 3/4, p252; Subject Term: HUMAN gene mapping; Subject Term: ANIMAL genome mapping; Subject Term: BACTERIAL artificial chromosomes; Subject Term: COMPLEMENTARY DNA; Subject Term: GENE libraries; Subject Term: FLUORESCENCE in situ hybridization; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Potosky, Arnold L.
AD  - National Cancer Institute
T1  - Prostate Cancer Treatment and Ten-Year Survival among Group/Staff HMO and Fee-for-Service Medicare Patients
JO  - Health Services Research
JF  - Health Services Research
Y1  - 1999/06//
VL  - 34
IS  - 2
SP  - 525
EP  - 546
SN  - 00179124
N1  - Accession Number: 0495363 Partial authors List; ; Keywords: Cancer;  HMO;  Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199908
N2  - A cohort of men age 65 and over diagnosed with prostate cancer between 1985 and the end of 1992 and followed through 1994. Subjects (n = 21,741) were ascertained by two population-based tumor registries covering the greater San Francisco--Oakland and Seattle--Puget Sound areas. Linkage of registry data with Medicare claims data and with HMO inpatient utilization data allowed the determination of health plan enrollment and the measurement of comorbid conditions. Multivariate regression models were used to examine HMO versus FFS treatment and survival differences adjusting for sociodemographic and clinical characteristics. Despite marked treatment differences for clinically localized prostate cancer, overall ten-year survival for patients enrolled in two nonprofit group/staff HMOs was equivalent to survival among patients receiving care in the FFS setting, even after adjustment for sociodemographic and clinical characteristics. Similar overall but better prostate cancer--specific survival among FFS patients is most plausibly explained by differences between the HMO and FFS patients in both tumor characteristics and unmeasured patient selection factors.
KW  - Health Production          I12
KW  - Analysis of Health Care Markets          I11
L3  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 107209577
T1  - Neutrophil and endothelial cell interactions in sepsis: the role of adhesion molecules.
AU  - Parent C
AU  - Eichacker PQ
Y1  - 1999/06//1999 Jun
N1  - Accession Number: 107209577. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508. 
KW  - Bacterial Infections -- Physiopathology
KW  - Cell Physiology
KW  - Sepsis -- Physiopathology
SP  - 427
EP  - 447
JO  - Infectious Disease Clinics
JF  - Infectious Disease Clinics
JA  - INFECT DIS CLIN NORTH AM
VL  - 13
IS  - 2
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Although adhesion molecules present on circulating neutrophils and endothelial cells are essential for normal host defense, generalized activation of these molecules has been implicated in the inflammatory tissue injury occurring during sepsis and septic shock. A review of both preclinical and clinical studies suggests, however, that although these molecules mediate tissue injury related to a variety of microbial and host inflammatory mediators, their predominant role during sepsis with infection is a protective one. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0891-5520
AD  - Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 10340176.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yoshimura, Teizo
AU  - Takeya, Motohiro
AU  - Ogata, Hiroomi
AU  - Yamashiro, Shigeo
AU  - Modi, William S.
AU  - Gillitzer, Reinhard
T1  - molecular Cloning of the Guinea Pig GRO Gene and Its Rapid Expression in the Tissues of Lipopolysaccharide–Injected Guinea Pigs.
JO  - International Archives of Allergy & Immunology
JF  - International Archives of Allergy & Immunology
Y1  - 1999/06//
VL  - 119
IS  - 2
M3  - Article
SP  - 101
EP  - 111
SN  - 10182438
AB  - Background: CXC chemokines, IL–8 and GRO, play a role in the recruitment of neutrophils in the human. The functional orthologues in the rat and mouse are CINC/KC and MIP–2. The lack of IL–8 made these animals less useful to study the role of IL–8 and GRO. Methods: Guinea pig (gp) cDNA libraries were screened for GRO and IL–1β. A gp genomic library was screened with a gpGRO cDNA probe. Expression of gpIL–8, gpGRO, gpTNFα, and gpIL–1β was investigated by Northern analysis and/or by in situ hybridization. Results: Two gpGRO cDNAs, a 3.0–kb gpGRO genomic DNA, and a gpIL–1β cDNA were cloned. gpGRO and gpIL–8 mRNA were detected in different tissues including lungs 1 h after intraperitoneal injection of lipopolysaccharide (LPS) into guinea pigs. gpGRO, gpIL–8, gpTNFα, and gpIL–1β expression peaked at 3 h in the lungs. Both gpGRO and gpIL–8 mRNA were detected in the cells in alveolar spaces and bronchial epithelial cells. However, gpGRO mRNA, but not gpIL–8, was also expressed in endothelial cells and vascular smooth muscle cells. Conclusions: gpGRO and gpIL–8 mRNA rapidly accumulated in the lungs of guinea pigs after LPS injection. Expression of gpIL–8 and gpGRO mRNA appeared to be independent from TNFα– or IL–1β–stimulation in this model. A high level expression of gpGRO in vascular cells suggest an important role of GRO in the sequestration of neutrophils and multi–organ injuries induced by LPS. The guinea pig will provide an excellent model to study the roles of IL–8 and GRO, important inflammatory mediators in the human. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Archives of Allergy & Immunology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GUINEA pigs
KW  - MOLECULAR cloning
KW  - CHEMOKINES
KW  - CYTOKINES
KW  - INFLAMMATION
KW  - NEUTROPHILS
KW  - Chemokine
KW  - Cytokine
KW  - Neutrophil infiltration
N1  - Accession Number: 11335541; Yoshimura, Teizo 1 Takeya, Motohiro 2 Ogata, Hiroomi 2 Yamashiro, Shigeo 1 Modi, William S. 3 Gillitzer, Reinhard 4; Affiliation:  1: Immunopathology Section, Laboratory of Immunobiology  2: Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan  3: SAIC, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, Md., USA  4: Department of Dermatology, University of Würzburg Medical School, Würzburg, Germany; Source Info: 1999, Vol. 119 Issue 2, p101; Subject Term: GUINEA pigs; Subject Term: MOLECULAR cloning; Subject Term: CHEMOKINES; Subject Term: CYTOKINES; Subject Term: INFLAMMATION; Subject Term: NEUTROPHILS; Author-Supplied Keyword: Chemokine; Author-Supplied Keyword: Cytokine; Author-Supplied Keyword: Neutrophil infiltration; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3  - 10.1159/000024184
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Zahn, Theodore P.
AU  - Mirsky, Allan F.
T1  - Reaction Time Indicators of Attention Deficits in Closed Head Injury.
JO  - Journal of Clinical & Experimental Neuropsychology
JF  - Journal of Clinical & Experimental Neuropsychology
Y1  - 1999/06//
VL  - 21
IS  - 3
M3  - Article
SP  - 352
EP  - 367
PB  - Taylor & Francis Ltd
SN  - 13803395
AB  - The nature of deficits in attention in closed head injury (CHI) was studied by three reaction time (RT) paradigms given to 20 patients who had a CHI 2 or more years previously and to 25 controls. We studied the effects of temporal uncertainty by varying the length and regularity of the preparatory interval, the effects of stimulus modality uncertainty on simple RT to tones and lights, and the effects of response selection in choice RT. The CHI group showed slower and more variable RT than controls under all conditions. In addition, a long preparatory interval on the preceding trial retarded RT more in the CHI group, and they showed greater effects of stimulus modality uncertainty. Both of these findings suggest a difficulty in shifting attention to unexpected stimuli. These greater effects on RT of variations of attention or preparation in CHI may account for their greater within-subject variability possibly due to frontal lobe damage. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Clinical & Experimental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ATTENTION
KW  - HEAD injuries
N1  - Accession Number: 4561535; Zahn, Theodore P. 1 Mirsky, Allan F. 1; Affiliation:  1: National Institute of Mental Health, Section on Clinical and Experimental Neuropsychology, Laboratory of Brain and Cognition, Bethesda, MD, USA; Source Info: Jun99, Vol. 21 Issue 3, p352; Subject Term: ATTENTION; Subject Term: HEAD injuries; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Etzioni, Ruth D.
AU  - Feuer, Eric J.
AU  - Sullivan, Sean D.
AU  - Lin, Danyu
AU  - Chengcheng Hu, Danyu
AU  - Ramsey, Scott D.
T1  - On the use of survival analysis techniques to estimate medical care costs.
JO  - Journal of Health Economics
JF  - Journal of Health Economics
Y1  - 1999/06//
VL  - 18
IS  - 3
M3  - Article
SP  - 365
EP  - 380
SN  - 01676296
AB  - Measurement of treatment costs is important in the evaluation of medical interventions. Accurate cost estimation is problematic, when cost records are incomplete. Methods from the survival analysis literature have been proposed for estimating costs using available data. In this article, we clarify assumptions necessary for validity of these techniques. We demonstrate how assumptions needed for valid survival analysis may be violated when these methods are applied to cost estimation. Our observations are confirmed through simulations and empirical data analysis. We conclude that survival analysis approaches are not generally appropriate for the analysis of medical costs and review several valid alternatives. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MEDICAL care costs
KW  - SURVIVAL analysis (Biometry)
KW  - COST estimates
KW  - HEALTH products
KW  - SIMULATION methods & models
KW  - DATA analysis
KW  - Medical interventions.
KW  - Survival analysis techniques
KW  - Treatment costs
N1  - Accession Number: 11895982; Etzioni, Ruth D. 1; Email Address: etzi@fhcrc.org Feuer, Eric J. 2 Sullivan, Sean D. 3 Lin, Danyu 4 Chengcheng Hu, Danyu 4 Ramsey, Scott D. 5; Affiliation:  1: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP-665, P.O. Box 19024, Seattle, WA 98109-1024, USA.  2: National Cancer Institute, USA.  3: School of Pharmacy, University of Washington, Seattle WA, USA.  4: Department of Biostatistics, University of Washington, Seattle WA, USA.  5: Departments of Medicine and Health Services, University of Washington, Seattle WA, USA.; Source Info: Jun1999, Vol. 18 Issue 3, p365; Subject Term: MEDICAL care costs; Subject Term: SURVIVAL analysis (Biometry); Subject Term: COST estimates; Subject Term: HEALTH products; Subject Term: SIMULATION methods & models; Subject Term: DATA analysis; Author-Supplied Keyword: Medical interventions.; Author-Supplied Keyword: Survival analysis techniques; Author-Supplied Keyword: Treatment costs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Saunders, Nicholas A.
AU  - Smith, Robert J.
AU  - Jetten, Anton M.
T1  - Regulation of Guanylate-Binding Protein Expression in Interferon-γ-Treated Human Epidermal Keratinocytes and Squamous Cell Carcinoma Cells.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1999/06//
VL  - 112
IS  - 6
M3  - Article
SP  - 977
EP  - 983
SN  - 0022202X
AB  - Interferon-γ is a potent inducer of growth arrest and squamous differentiation of human epidermal keratinocytes in vitro. In order to understand the proximate events regulating interferon-γ action we studied the relationship between interferon-γ-mediated induction of a cytoplasmic guanylate-binding protein and the expression of growth and differentiation marker genes in normal and transformed keratinocytes. Induction of guanylate-binding protein mRNA by interferon-γ was detectable at 4 h, was transcription dependent, and preceded changes in the expression of markers of growth arrest (E2F-1 mRNA downregulation) and differentiation (SQ37 mRNA induction). The Ec50 value for guanylate-binding protein induction (4 units interferon-γ per ml) was lower than previously reported for SQ37 (40 units interferon-γ per ml). Guanylate-binding protein mRNA appeared to be only moderately downregulated by modulators of the squamous phenotype such as retinoic acid and transforming growth factor-β1. In addition, mRNA levels of E2F-1 or SQ37 were not altered in several squamous carcinoma cell lines treated with interferon-γ. In contrast, guanylate-binding protein mRNA was highly induced in all these cell lines following interferon-γ treatment. Further analysis of the signal transduction pathway mediating interferon-γ responses using protein kinase inhibitors indicated that guanylate-binding protein induction in normal human epidermal keratinocyte cells was most likely protein kinase C independent. Our data suggest that more than one postreceptor interferon-γ signaling pathway exists in keratinocytes and that at least one of these pathways is defective in squamous carcinoma cells. Furthermore, our data demonstrated that the failure of the squamous carcinoma cells to undergo interferon-γ-induced growth arrest and differentiation is not due to an inherent defect in interferon-γ receptor activation,... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CARRIER proteins
KW  - SQUAMOUS cell carcinoma
KW  - INTERFERONS
KW  - PHYSIOLOGY
KW  - cancer
KW  - epithelium
KW  - Squamous differentiation
N1  - Accession Number: 5167184; Saunders, Nicholas A. 1 Smith, Robert J. 2 Jetten, Anton M. 2; Affiliation:  1: Epithelial Pathobiology Group, Center For Immunology and Cancer Research, University of Queensland Department of Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia;  2: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, U.S.A.; Source Info: Jun99, Vol. 112 Issue 6, p977; Subject Term: CARRIER proteins; Subject Term: SQUAMOUS cell carcinoma; Subject Term: INTERFERONS; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: cancer; Author-Supplied Keyword: epithelium; Author-Supplied Keyword: Squamous differentiation; Number of Pages: 7p; Illustrations: 6 Black and White Photographs, 4 Graphs; Document Type: Article
L3  - 10.1046/j.1523-1747.1999.00611.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107231727
T1  - Gabapentin as an adjuvant to opioid analgesia for neuropathic cancer pain.
AU  - Caraceni A
AU  - Zecca E
AU  - Martini C
AU  - De Conno F
Y1  - 1999/06//1999 Jun
N1  - Accession Number: 107231727. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836. 
KW  - Cancer Pain -- Drug Therapy
KW  - Anticonvulsants -- Therapeutic Use
KW  - Narcotics -- Therapeutic Use
KW  - Drug Therapy, Combination
KW  - Anticonvulsants -- Administration and Dosage
KW  - Narcotics -- Administration and Dosage
KW  - Clinical Research
KW  - Pain Measurement
KW  - Confidence Intervals
KW  - T-Tests
KW  - Fisher's Exact Test
KW  - Descriptive Statistics
KW  - Sex Factors
KW  - Age Factors
KW  - Male
KW  - Female
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Treatment Outcomes
KW  - Human
SP  - 441
EP  - 445
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 17
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - Gabapentin was administered as an 'add on' therapy to 22 patients with neuropathic cancer pain only partially responsive to opioid therapy. Global pain, burning pain, shooting pain episodes, and allodynia were assessed separately. Gabapentin was given for at least a week and efficacy was assessed after 7 to 14 days of therapy. Global pain score decreased from a mean (+/- SD) of 6.4 (+/- 1.5) to 3.2 (+/- 1.3) (95% confidence interval of the baseline minus final score differences [95% CI] = 1.0-2.4). Burning pain intensity decreased from a mean (+/- SD) of 5.1 (+/- 3.6) to 2.0 (+/- 2.3) (95% CI = 1.5-3.8), and episodes of shooting pain decreased in frequency from 7.2 (+/- 3.7) to 2.2 (+/- 2.2) daily episodes (95% CI = 1.8-4.3). Allodynia was found in 9 patients and disappeared in 7 during gabapentin administration. Twenty patients judged the new drug efficacious in relieving their symptoms. The potential role of gabapentin as an adjuvant to opioid analgesia in cancer pain is discussed. (c) U.S. Cancer Pain Relief Committee, 1999.
SN  - 0885-3924
AD  - Neurology Unit, Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Via Venezian 1, 20133 Milan, Italy
U2  - PMID: 10388250.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107231727&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107208329
T1  - Pain after periodontal scaling and root planing.
AU  - Philstrom BL
AU  - Hargreaves KM
AU  - Bouwsma OJ
AU  - Myers WR
AU  - Goodale MB
AU  - Doyle MJ
Y1  - 1999/06//
N1  - Accession Number: 107208329. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Heft-Parker Pain Scale. Grant Information: Procter & Gamble Company, National Institutes of Health/National Institute of Dental and Craniofacial Research grant DE09737 and the Erwin M. Schaffer Chair in Periodontal Research, University of Minnesota School of Dentistry, Minneapolis. NLM UID: 7503060. 
KW  - Dental Scaling -- Adverse Effects
KW  - Postoperative Pain -- Etiology
KW  - Periodontitis -- Therapy
KW  - Toothache -- Etiology
KW  - Clinical Assessment Tools
KW  - Analgesics -- Administration and Dosage
KW  - Pain Measurement
KW  - Postoperative Pain -- Drug Therapy
KW  - Root Planing -- Adverse Effects
KW  - Toothache -- Drug Therapy
KW  - Research Subject Recruitment
KW  - Academic Medical Centers
KW  - Minnesota
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Self Assessment
KW  - Prospective Studies
KW  - Linear Regression
KW  - Logistic Regression
KW  - Survival Analysis
KW  - Wilcoxon Rank Sum Test
KW  - Statistical Significance
KW  - Funding Source
KW  - P-Value
KW  - Sex Factors
KW  - Odds Ratio
KW  - Visual Analog Scaling
KW  - Descriptive Statistics
KW  - Education, Continuing (Credit)
KW  - Human
SP  - 801
EP  - 807
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 6
CY  - Chicago, Illinois
PB  - American Dental Association
AB  - BACKGROUND: Although periodontal scaling and root planing, or SRP, is one of the most common procedures used in dental practice, there is little information available about the degree of postprocedural pain associated with it. The authors undertook this study to document the intensity and duration of pain after SRP with a view toward helping practitioners and their patients manage postprocedural discomfort. METHODS: Using the Heft-Parker self-assessment pain scale, 52 adults with moderate periodontitis evaluated their pain before and after SRP conducted with local anesthetic. RESULTS: After SRP, 28 percent of all patients reported faint-to-weak pain, 18 percent experienced weak-to-mild pain, 28 percent experienced mild-to-moderate pain, 8 percent had moderate-to-strong pain and 8 percent reported strong-to-intense pain. The average time to onset of maximum pain was approximately three hours after SRP, and the average duration of mild or greater pain was about six hours. Upon awakening the morning after SRP, subjects found that pain had returned to pre-SRP levels. Overall, 23 percent of all patients reported self-medicating with analgesics to relieve postprocedural pain. Women self-medicated earlier (P < .05) and more often than men (43 percent vs. 10 percent; P < .05). CONCLUSIONS: Patients experienced significant duration and magnitude of pain after SRP. This pain peaked between two and eight hours after SRP, lasted about six hours, and returned to pre-SRP levels by the morning after the procedure. Almost 25 percent of all patients self-medicated to relieve pain after SRP, and women took analgesic medication earlier and more often than men. CLINICAL IMPLICATIONS: Practitioners should consider using appropriate analgesic drugs to alleviate mild-to-moderate pain after SRP. On the basis of this study, it would appear that an analgesic that has a peak effect two to eight hours after the completion of SRP would be the most appropriate medication. Moreover, it is unlikely that analgesic medication would be needed by most patients beyond the day on which SRP was performed.
SN  - 0002-8177
AD  - National Institutes of Health/National Institute of Dental and Craniofacial Research Oral Health Clinical Research Center, 17-116 Moos Tower, School of Dentistry, University of Minnesota, 515 Delaware St. S.E., Minneapolis, MN 55455
U2  - PMID: 10377637.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107208339
T1  - Observations. Learning, immunology and allergic responses.
AU  - Slavkin HC
Y1  - 1999/06//
N1  - Accession Number: 107208339. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Hypersensitivity
KW  - Mouth Mucosa -- Immunology
KW  - Food Hypersensitivity -- Immunology
KW  - Mice
KW  - Hypersensitivity -- Diagnosis
KW  - Hypersensitivity -- Therapy
SP  - 863
EP  - 867
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 6
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, MD 20892-2290
U2  - PMID: 10377646.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107206627
T1  - Who walks? Factors associated with walking behavior in disabled older women with and without self-reported walking difficulty.
AU  - Simonsick EM
AU  - Guralnik JM
AU  - Fried LP
Y1  - 1999/06//6/ 1/1999
N1  - Accession Number: 107206627. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Subscale of the Hopkins Symptom Checklist; Mini-Mental Status Examination (MMSE) (Folstein et al); Geriatric Depression Scale (GDS). NLM UID: 7503062. 
KW  - Disabled -- Psychosocial Factors
KW  - Walking -- Psychosocial Factors
KW  - Women -- Psychosocial Factors
KW  - Chi Square Test
KW  - Logistic Regression
KW  - Questionnaires
KW  - Accidental Falls
KW  - Maryland
KW  - Comparative Studies
KW  - Cross Sectional Studies
KW  - Depression -- Psychosocial Factors
KW  - Odds Ratio
KW  - Psychological Tests
KW  - Prospective Studies
KW  - Body Mass Index
KW  - Socioeconomic Factors
KW  - Urban Health
KW  - Aged
KW  - Female
KW  - Human
SP  - 672
EP  - 680
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVES: To determine how severity of walking difficulty and sociodemographic, psychosocial, and health-related factors influence walking behavior in disabled older women. DESIGN: Cross-sectional analyses of baseline data from the Women's Health and Aging Study (WHAS). SETTING: An urban community encompassing 12 contiguous zip code areas in the eastern portion of Baltimore City and part of Baltimore County, Maryland. PARTICIPANTS: A total of 920 moderately to severely disabled community-resident women, aged 65 years and older, identified from an age-stratified random sample of Medicare beneficiaries. MEASUREMENTS: Walking behavior was defined as minutes walked for exercise and total blocks walked per week. Independent variables included self-reported walking difficulty, sociodemographic factors, psychological status (depression, mastery, anxiety, and cognition), and health-related factors (falls and fear of falling, fatigue, vision and balance problems, weight, smoking, and cane use). RESULTS: Walking at least 8 blocks per week was strongly negatively related to severity of walking difficulty. Independent of difficulty level, older age, black race, fatigue, obesity, and cane use were also negatively associated with walking; living alone and high mastery had a positive association with walking. CONCLUSIONS: Even among functionally limited women, sociocultural, psychological, and health-related factors were independently associated with walking behavior. Thus, programs aimed at improving walking ability need to address these factors in addition to walking difficulties to maximize participation and compliance.
SN  - 0002-8614
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Suite 3C-309, Bethesda, MD 20892-9205
U2  - PMID: 10366165.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Endicott, Jean
AU  - Amsterdam, Jay
AU  - Eriksson, Elias
AU  - Frank, Ellen
AU  - Freeman, Ellen
AU  - Hirschfeld, Robert
AU  - Ling, Frank
AU  - Parry, Barbara
AU  - Pearlstein, Teri
AU  - Rosenbaum, Jerrold
AU  - Rubinow, David
AU  - Schmidt, Peter
AU  - Severino, Sally
AU  - Steiner, Meir
AU  - Stewart, Donna E.
AU  - Thys-Jacobs, Susan
T1  - Is Premenstrual Dysphoric Disorder a Distinct Clinical Entity?
JO  - Journal of Women's Health & Gender-Based Medicine
JF  - Journal of Women's Health & Gender-Based Medicine
Y1  - 1999/06//
VL  - 8
IS  - 5
M3  - Article
SP  - 663
PB  - Mary Ann Liebert, Inc.
SN  - 15246094
AB  - The article analyzes the concept of premenstrual dysphoric disorder (PMDD) as a distinct clinical disorder. The article focuses on a round-table discussion on the question, a wealth of information which was reviewed by a panel of experts. The group reached the consensus that PMDD is a distinct entity with clinical and biologic profiles dissimilar to those seen in other disorders. Thus, the relative safety and efficacy of potential treatments for PMDD can be evaluated, and, indeed, many of those present thought that sufficient evidence is now available to support the use of selective serotonin reuptake inhibitors in this disorder. Researchers in to PMDD are aware that application of different methods for assessing severity of symptoms results in somewhat different study populations. A consistent measure is still required to improve reliability in the women identified for studies. The application of an objective rating scale at both the late luteal and midfollicular phases of the cycle, administered by interview, can improve reliability.
KW  - PREMENSTRUAL syndrome
KW  - MENSTRUATION disorders
KW  - CONFERENCES & conventions
KW  - WOMEN -- Diseases
KW  - DEMOGRAPHY
KW  - FEMALE reproductive organs -- Diseases
N1  - Accession Number: 5627823; Endicott, Jean 1 Amsterdam, Jay 2 Eriksson, Elias 3 Frank, Ellen 4 Freeman, Ellen 2 Hirschfeld, Robert 5 Ling, Frank 6 Parry, Barbara 7 Pearlstein, Teri 8 Rosenbaum, Jerrold 9 Rubinow, David 10 Schmidt, Peter 10 Severino, Sally 11 Steiner, Meir 12 Stewart, Donna E. 13 Thys-Jacobs, Susan 14; Affiliation:  1: Columbia University, New York, New York.  2: University of Pennsylvania, Philadelphia, Pennsylvania.  3: University of Goteborg, Sweden.  4: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania.  5: University of Texas-Galveston, Texas.  6: University of Tenneessee, Memphis Tennessee.  7: University of California, San Diego, California.  8: Butler Hospital, Providence, Rhode Island.  9: Massachusetts General Hospital, Boston, Massachusetts.  10: National Institute of Mental Health, Bethesda, Maryland.  11: University of New Mexico, Albuquerque, New Mexico.  12: St. Joseph's Hospital McMaster University, Ontario, Canada.  13: The Toronto Hospital, University of Toronto, Ontario, Canada.  14: St. Luke's Roosevelt Center, New York, New York.; Source Info: Jun99, Vol. 8 Issue 5, p663; Subject Term: PREMENSTRUAL syndrome; Subject Term: MENSTRUATION disorders; Subject Term: CONFERENCES & conventions; Subject Term: WOMEN -- Diseases; Subject Term: DEMOGRAPHY; Subject Term: FEMALE reproductive organs -- Diseases; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 17p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107211171
T1  - Primary failure of tooth eruption: a unique case.
AU  - O'Connell AC
AU  - Torske KR
Y1  - 1999/06//1999 Jun
N1  - Accession Number: 107211171. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101576782. 
KW  - Tooth Abnormalities -- Surgery -- In Infancy and Childhood
KW  - Tooth Eruption -- Physiology
KW  - Female
KW  - Child
SP  - 714
EP  - 720
JO  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JF  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JA  - ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDO
VL  - 87
IS  - 6
CY  - New York, New York
PB  - Elsevier Science
AB  - Primary failure of tooth eruption rarely occurs. This case represents a rare clinical situation and appears to reflect a generalized disturbance in the eruptive process, inasmuch as (1) deciduous and permanent dentition are affected, (2) incisors, molars, and premolars are involved in all quadrants, (3) skeletal and craniofacial growth are within normal limits, and (4) no systemic/genetic anomalies were detected. This is the first such case reported in the literature; diagnosis and management are discussed.
SN  - 1079-2104
AD  - National Institute of Dental Research, National Institutes of Health
U2  - PMID: 10397664.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107210094
T1  - The impact of tailored interventions on a community health center population.
AU  - Rimer BK
AU  - Conaway M
AU  - Lyna P
AU  - Glassman B
AU  - Yarnall KSH
AU  - Lipkus I
AU  - Barber LT
Y1  - 1999/06//1999 Jun
N1  - Accession Number: 107210094. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Europe; Health Promotion/Education; Nursing; Peer Reviewed; UK & Ireland. Grant Information: NIH grant number 5RO1CA 59734-04. NLM UID: 8406280. 
KW  - Patient Compliance -- Evaluation -- North Carolina
KW  - Mammography
KW  - Cervical Smears
KW  - Random Sample
KW  - Interviews
KW  - Models, Theoretical
KW  - Blacks
KW  - Socioeconomic Factors
KW  - Chi Square Test
KW  - Mantel-Haenszel Test
KW  - Logistic Regression
KW  - Community Health Services
KW  - Program Evaluation
KW  - North Carolina
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 125
EP  - 140
JO  - Patient Education & Counseling
JF  - Patient Education & Counseling
JA  - PATIENT EDUC COUNS
VL  - 37
IS  - 2
PB  - Elsevier Science
SN  - 0738-3991
AD  - National Cancer Institute, 6130 Executive Blvd., Room 242, Bethesda, MD 20892-7335
U2  - PMID: 14528540.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Furukawa, Toshi A
AU  - Anraku, Kazutaka
AU  - Hiroe, Takahiro
AU  - Takahashi, Kiyoshi
AU  - Yoshimura, Reiji
AU  - Hirai, Toshiyuki
AU  - Kitamura, Toshinori
AU  - Takahashi, Kiyohisa
AU  - Furukawa, Toshi A.
T1  - A polydiagnostic study of depressive disorders according to DSM-IV and 23 classical diagnostic systems.
JO  - Psychiatry & Clinical Neurosciences
JF  - Psychiatry & Clinical Neurosciences
Y1  - 1999/06//
VL  - 53
IS  - 3
M3  - Article
SP  - 387
EP  - 396
PB  - Wiley-Blackwell
SN  - 13231316
AB  - AbstractThe classification of mood disorders is one of the most highly debated topics in modern psychiatry. The introduction of DSM-III (and its followers) has set a new standard in this controversy but little empirical evidence is available as to how the various classical diagnostic categories of mood disorders by Kraepelin, Schneider, Leonhard, Hamilton, Kielholz, Winokur and others compare with this new standard. The Intensive Prospective Study arm of the Group for Longitudinal Affective Disorders Study has studied a broad spectrum of mood disorders in 23 participating centres from all over Japan with a polydiagnostic semistructured interview called Comprehensive Assessment List of Affective disorders. In this paper we examined how the various classical diagnostic systems of depressive disorders correspond to the DSM-IV diagnoses, and found the following: (1) The classical ‘neurotic’ or ‘psychogenic’ depressions are diagnosed as major depression and not as dysthymia in DSM-IV; although dysthymia was dubbed as ‘depressive neurosis’ in DSM-III, its criteria were not true to the traditional usage of the term. Viewed from the other side of the coin, DSM-IV can be said to stand in the unitary tradition. (2) Some of the classical diagnostic categories such as Schneider’s depressive psychopathy and Klein’s acute dysphoria as well as modern ones such as Akiskal’s subaffective dysthymia and Angst’s recurrent brief depression were rarely seen in traditional psychiatric treatment settings. (3) Comparisons of the unique diagnostic systems such as those by Leonhard, Winokur and Berner warrant further studies on their validity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL depression -- Diagnosis
KW  - AFFECTIVE disorders
KW  - depressive disorder
KW  - nosology
KW  - polydiagnosis
N1  - Accession Number: 5167853; Furukawa, Toshi A 1 Anraku, Kazutaka 1 Hiroe, Takahiro 1 Takahashi, Kiyoshi 1 Yoshimura, Reiji 2 Hirai, Toshiyuki 3 Kitamura, Toshinori 4 Takahashi, Kiyohisa 3 Furukawa, Toshi A.; Affiliation:  1: Department of Psychiatry, Nagoya City University Medical School, Nagoya,  2: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu,  3: Musashi Hospital, National Center of Neurology and Psychiatry, Kodaira,  4: National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan MD, PhD, Department of Psychiatry, Nagoya City University Medical School, Mizuho-cho, Mizuho-ku, Nagoya 467–8601, Japan. Email: <toshi.furukawa@ nifty.ne.jp>; Source Info: Jun99, Vol. 53 Issue 3, p387; Subject Term: MENTAL depression -- Diagnosis; Subject Term: AFFECTIVE disorders; Author-Supplied Keyword: depressive disorder; Author-Supplied Keyword: nosology; Author-Supplied Keyword: polydiagnosis; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
L3  - 10.1046/j.1440-1819.1999.00562.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Knebel, Ann R.
AU  - Leidy, Nancy Kline
AU  - Sherman, Sandra
T1  - Health related quality of life and disease severity in patients with alpha-1 antitrypsin deficiency.
JO  - Quality of Life Research
JF  - Quality of Life Research
Y1  - 1999/06//
VL  - 8
IS  - 4
M3  - Article
SP  - 385
EP  - 391
PB  - Springer Science & Business Media B.V.
SN  - 09629343
AB  - Study question: To describe health-related quality of life (HRQL) in individuals with alpha-1 antitrypsin (AAT) deficiency, examine the cross-sectional relationship between disease severity and HRQL, and explore changes in lung function and HRQL over time in a subset of these individuals. Material/Methods: Forty-five adults with AAT deficiency and moderate to severe emphysema completed the Chronic Respiratory Disease Questionnaire (CRQ), six-minute walk distance (6-MWD) and pulmonary function tests (PFTs). Twenty of the 45 were followed for two additional years with repeated measurements of CRQ and PFTs. Results: The mean ± SD age was 49 ± 8 years. Initial CRQ subscale scores were: dyspnea 17.5 ± 4.3; fatigue 17.0 ± 5.46; emotional function 33.1 ± 8.67; and mastery 21.7 ± 4.65. No relationship was found between percent predicted forced expiratory volume in one second (FEV<MATH>_1</MATH>%) and CRQ score; 6 MWD and fatigue correlated significantly (r = 0.32, p < 0.05). Repeated PFT and CRQ measurements in 20 subjects showed statistically significant declines in FEV<MATH>_1</MATH> and slow vital capacity (SVC), but no change in CRQ scores. Conclusions: Results suggest persons with AAT deficiency face challenges to HRQL that are similar to older adults with chronic pulmonary disease. Further research is needed on the nature of the relationship between disease severity and HRQL in this population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Quality of Life Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ALPHA 1-antitrypsin deficiency
KW  - PULMONARY emphysema
KW  - PULMONARY function tests
KW  - QUALITY of life
KW  - HEALTH status indicators
KW  - HEALTH
KW  - Dyspnea
KW  - Functional status
KW  - Health outcome assessment
KW  - Pulmonary emphysema
KW  - Symptoms
N1  - Accession Number: 11501199; Knebel, Ann R. 1; Email Address: aknebel@nih.gov Leidy, Nancy Kline 2 Sherman, Sandra 1; Affiliation:  1: National Institutes of Health, Clinical Center Nursing Department  2: MEDTAP International and National Institute of Nursing Research, Division of Intramural Research; Source Info: Jun1999, Vol. 8 Issue 4, p385; Subject Term: ALPHA 1-antitrypsin deficiency; Subject Term: PULMONARY emphysema; Subject Term: PULMONARY function tests; Subject Term: QUALITY of life; Subject Term: HEALTH status indicators; Subject Term: HEALTH; Author-Supplied Keyword: Dyspnea; Author-Supplied Keyword: Functional status; Author-Supplied Keyword: Health outcome assessment; Author-Supplied Keyword: Pulmonary emphysema; Author-Supplied Keyword: Symptoms; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Baker, Laurence C.
AU  - Brown, Martin L.
T1  - Managed care, consolidation among health care providers, and health care: Evidence from mammography.
JO  - RAND Journal of Economics (RAND Journal of Economics)
JF  - RAND Journal of Economics (RAND Journal of Economics)
Y1  - 1999///Summer99
VL  - 30
IS  - 2
M3  - Article
SP  - 351
EP  - 374
PB  - RAND Journal of Economics
SN  - 07416261
AB  - We discuss the effects of managed care on the structure of the health care delivery system, focusing on managed-care-induced consolidation among health care providers. We empirically investigate the relationship between HMO market share and mammography providers. We find evidence of consolidation: increases in HMO activity are associated with reductions in the number of mammography providers and with increases in the number of services produced by remaining providers. We also find that increases in HMO market share are associated with reductions in costs for mammography and with increases in waiting times for appointments, but not with worse health outcomes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of RAND Journal of Economics (RAND Journal of Economics) is the property of RAND Journal of Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MANAGED care plans (Medical care)
KW  - MEDICAL care
KW  - MARKET share
KW  - MAMMOGRAMS
KW  - MEDICAL care costs
KW  - WOMEN -- Health
KW  - PUBLIC health
KW  - CANCER in women
N1  - Accession Number: 2203810; Baker, Laurence C. 1; Email Address: laurence.baker@stanford.edu; Brown, Martin L. 2; Email Address: mb53o@nci.nih.gov; Affiliations: 1: Stanford University and NBER; 2: National Cancer Institute; Issue Info: Summer99, Vol. 30 Issue 2, p351; Thesaurus Term: MANAGED care plans (Medical care); Thesaurus Term: MEDICAL care; Thesaurus Term: MARKET share; Subject Term: MAMMOGRAMS; Subject Term: MEDICAL care costs; Subject Term: WOMEN -- Health; Subject Term: PUBLIC health; Subject Term: CANCER in women; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 24p; Illustrations: 7 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
ID  - 107210829
T1  - Progression in acute stroke: value of the initial NIH stroke scale score on patient stratification in future trials.
AU  - DeGraba TJ
AU  - Hallenbeck JM
AU  - Pettigrew KD
AU  - Dutka AJ
AU  - Kelly BJ
AU  - DeGraba, T J
AU  - Hallenbeck, J M
AU  - Pettigrew, K D
AU  - Dutka, A J
AU  - Kelly, B J
Y1  - 1999/06//1999 Jun
N1  - Accession Number: 107210829. Language: English. Entry Date: 19990901. Revision Date: 20161126. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Instrumentation: NIH Stroke Scale. Grant Information: Intramural Stroke Branch of the National Institute of Neurological Disorders and Stroke. NLM UID: 0235266. 
KW  - Stroke -- Physiopathology
KW  - Acute Disease
KW  - Clinical Assessment Tools
KW  - NIH Stroke Scale
KW  - Disease Progression
KW  - Chi Square Test
KW  - Logistic Regression
KW  - T-Tests
KW  - Mann-Whitney U Test
KW  - Aged
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 1208
EP  - 1212
JO  - Stroke (00392499)
JF  - Stroke (00392499)
JA  - STROKE
VL  - 30
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Background and Purpose: The objective was to determine the occurrence of neurological changes during the first 48 hours after acute stroke as it relates to initial stroke severity.Methods: The National Institutes of Health Stroke Scale (NIHSS) was performed serially for the first 48 hours on 127 consecutive ischemic stroke patients (129 strokes) admitted to the neuroscience intensive care unit. Incidence of stroke progression (a >/=3-point increase on the NIHSS) was recorded and analysis performed to determine its association with initial stroke severity and other demographic and physiological variables. Deficit resolution by 48 hours, defined as an NIHSS score of 0 or 1, measured the frequency of functional recovery predicted by the initial deficit.Results: Overall progression was noted in 31% of events (40/129). Applying Bayes' solution to the observed frequency of worsening, the greatest likelihood of predicting future patient progression occurs with stratification at NIHSS scores of </=7 and >7. Patients with an initial NIHSS of </=7 experienced a 14.8% (13/88) worsening rate versus a those with a score of >7 with a 65.9% (27/41) worsening rate (P<0.000005). Forty-five percent (40/88) of those with an initial score of </=7 were functionally normal at 48 hours, whereas only 2.4% (1/41) of those with scores of >7 returned to a normal examination within this period (chi2, P<0.000005).Conclusions: This study suggests that the early clinical course of the neurological deficit after acute stroke is dependent on the initial stroke severity and that a dichotomy in early outcome exists surrounding an initial NIHSS score of 7. These findings may have significant implications for the design and patient stratification in treatment protocols with respect to primary clinical outcome.
SN  - 0039-2499
AD  - National Institute of Neurological Disorders and Stroke, Stroke Branch,National Institutes of Health, Bethesda, MD, USA
AD  - Clinical Stroke Research Unit, Stroke Branch, NINDS, NIH, 36 Convent Drive MSC 4128, Bldg 36 Rm 4A-03, Bethesda, MD 20892-4128; e-mail: tjd@helix.nih.gov
U2  - PMID: 10356101.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Spalding, Judson W.
AU  - French, John E.
AU  - Tice, Raymond R.
AU  - Furedi-Machacek, Marianna
AU  - Haseman, Joseph K.
AU  - Tennant, Raymond W.
T1  - Development of a transgenic mouse model for carcinogenesis bioassays: evaluation of chemically induced skin tumors in Tg.AC mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/06//
VL  - 49
IS  - 2
M3  - Article
SP  - 241
EP  - 254
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Transgenic rodent models have emerged as potentially useful tools in the assessment of drug and chemical safety. The transgenic Tg.AC mouse carries an inducible v-Ha-ras oncogene that imparts the characteristic of genetically initiated skin to these animals. The induction of epidermal papillomas in the area of topically applied chemical agents, for duration of not more than 26 weeks acts as a reporter phenotype that defines the activity of the test article. We describe here the activity of six chemicals that have been previously characterized for activity in the standard 2-year bioassay conducted by the National Toxicology Program (NTP). Homozygous female Tg.AC mice were treated with benzene (BZ), benzethonium chloride (BZTC), o-benzyl-p-chlorophenol (BCP), 2-chloroethanol (2-CE), lauric acid diethanolamine (LADA) and triethanolamine (TEA). BZ and LADA induced skin papillomas in a dose-dependent manner, while BCP induced papillomas only at the highest dose. BZTC, 2-CE, and TEA exhibited no activity. The correspondence of chemical activity in Tg.AC mice with that in the 2-year bioassay was high. A comparison of responsiveness to BZ and LADA was made between hemizygous and homozygous female Tg.AC mice. Both genotypes appear to be equally sensitive to maximum doses of active compounds. The results reported here indicate that the Tg.AC transgenic mouse model can discriminate between carcinogens and noncarcinogens and that both mutagenic and nonmutagenic chemicals can be detected. These studies provide support for the adjunctive use of the Tg.AC transgenic mouse skin tumor model in drug and chemical safety assessment and for the prediction of the carcinogenic potential of chemicals. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Benzene
KW  - Biological assay
KW  - Transgenic mice
KW  - Oncogenes
KW  - Papilloma
KW  - Lauric acid diethanolamide
KW  - carcinogen bioassay
KW  - chemical carcinogens
KW  - skin cancer
KW  - skin cancer.
KW  - Tg.AC transgenic mice
N1  - Accession Number: 44405775; Spalding, Judson W. 1; Email Address: spalding@niehs.nih.gov; French, John E. 1; Tice, Raymond R. 2; Furedi-Machacek, Marianna 2; Haseman, Joseph K. 3; Tennant, Raymond W. 1; Affiliations: 1: Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Laboratory of Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 3: Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709; Issue Info: Jun1999, Vol. 49 Issue 2, p241; Thesaurus Term: Benzene; Thesaurus Term: Biological assay; Subject Term: Transgenic mice; Subject Term: Oncogenes; Subject Term: Papilloma; Subject Term: Lauric acid diethanolamide; Author-Supplied Keyword: carcinogen bioassay; Author-Supplied Keyword: chemical carcinogens; Author-Supplied Keyword: skin cancer; Author-Supplied Keyword: skin cancer.; Author-Supplied Keyword: Tg.AC transgenic mice; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 14p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2002-06292-009
AN  - 2002-06292-009
AU  - Norquist, Grayson S.
T1  - Information needs for community practice: Responding to the challenge.
JF  - Journal of Mental Health Policy and Economics
JO  - Journal of Mental Health Policy and Economics
JA  - J Ment Health Policy Econ
Y1  - 1999/06//
VL  - 2
IS  - 2
SP  - 87
EP  - 89
CY  - Italy
PB  - ICMPE
SN  - 1091-4358
SN  - 1099-176X
AD  - Norquist, Grayson S., National Inst of Mental Health, Div of Services & Intervention Research, 6001 Executive Boulevard, Bethesda, MD, US, 20892-9629
N1  - Accession Number: 2002-06292-009. PMID: 11967414 Partial author list: First Author & Affiliation: Norquist, Grayson S.; National Inst of Mental Health, Div of Services & Intervention Research, Bethesda, MD, US. Release Date: 20021120. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Community Psychology; Experimentation; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jun, 1999. 
AB  - Notes efforts by the National Institute of Mental Health to produce a broad expansion in its research portfolio that will produce data to inform how to improve community practice and public mental health. Such data should be relevant to the diverse needs of payers, policymakers, clinicians, families and consumers. It is expected that data from varied research efforts (see S. M. Essock, 1999 and A. F. Lehman, 1998) will tell what works, what interventions are best for which groups of people and how to ensure that the best and most cost-effective interventions possible are delivered in all practice settings. Research like this should lead toward improving public mental health and reducing the burden of mental disorders for society. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - community practice
KW  - public mental health
KW  - research efforts
KW  - 1999
KW  - Community Mental Health Services
KW  - Community Psychology
KW  - Experimentation
KW  - Mental Health
KW  - 1999
DO  - 10.1002/(SICI)1099-176X(199906)2:2<87::AID-MHP45>3.0.CO;2-I
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UR  - gnorquis@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2004-17592-001
AN  - 2004-17592-001
AU  - Wiggins, Jerry S.
T1  - Learning the errors of our ways.
JF  - Contemporary Psychology
JO  - Contemporary Psychology
Y1  - 1999/06//
VL  - 44
IS  - 3
SP  - 195
EP  - 196
CY  - US
PB  - American Psychological Association
SN  - 0010-7549
N1  - Accession Number: 2004-17592-001. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wiggins, Jerry S.; Gerontology Research Center, National Institute on Aging, Baltimore, MD, US. Release Date: 20040927. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Judgment (Not Diagnosis); Decision Making; Mental Health Personnel; Psychodiagnosis; Psychological Assessment. Minor Descriptor: Clinical Psychology; Graduate Psychology Education; Inference. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Reviewed Item: Garb, Howard N. Studying the Clinician: Judgment Research and Psychological Assessment=Washington, DC: American Psychological Association, 1998. 333 pp. $39.95; 1998. References Available: Y. Page Count: 2. Issue Publication Date: Jun, 1999. 
AB  - To convey the nature of empirical research on clinician judgment, H. N. Garb (see record [rid]1998-07601-000[/rid]) has attempted a synthesis of results from more then 1,000 studies. The reviewer explains that the readership to whom this book is primarily addressed (clinical students and practitioners) is never treated with condescension nor baffled by arcane digressions. Topics discussed include the implications of research on clinical judgment and decision making, graduate education in clinical psychology, and learning clinical inference. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - clinical judgment
KW  - psychological assessment
KW  - clinical inference
KW  - decision making
KW  - mental health professionals
KW  - graduate education
KW  - clinical psychology
KW  - 1999
KW  - Clinical Judgment (Not Diagnosis)
KW  - Decision Making
KW  - Mental Health Personnel
KW  - Psychodiagnosis
KW  - Psychological Assessment
KW  - Clinical Psychology
KW  - Graduate Psychology Education
KW  - Inference
KW  - 1999
U2  - Garb, Howard N. (1998); Studying the Clinician: Judgment Research and Psychological Assessment; Washington, DC: American Psychological Association, 1998. 333 pp. $39.95; 1-55798-483-2.
DO  - 10.1037/001992
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17592-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 1999-03230-001
AN  - 1999-03230-001
AU  - Stillman, Frances
AU  - Hartman, Anne
AU  - Graubard, Barry
AU  - Gilpin, Elizabeth
AU  - Chavis, David
AU  - Garcia, John
AU  - Wun, Lap-Ming
AU  - Lynn, William
AU  - Manley, Marc
T1  - The American stop smoking intervention study: Conceptual framework and evaluation design.
JF  - Evaluation Review
JO  - Evaluation Review
JA  - Eval Rev
Y1  - 1999/06//
VL  - 23
IS  - 3
SP  - 259
EP  - 280
CY  - US
PB  - Sage Publications
SN  - 0193-841X
SN  - 1552-3926
N1  - Accession Number: 1999-03230-001. PMID: 10538783 Other Journal Title: Evaluation Quarterly. Partial author list: First Author & Affiliation: Stillman, Frances; National Cancer Institute, Washington, DC, US. Release Date: 19991001. Correction Date: 20130422. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Methodology; Program Evaluation; Smoking Cessation; Tobacco Smoking. Minor Descriptor: Concepts; Experimentation; Government Policy Making; Prevention; Strategies. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Page Count: 22. Issue Publication Date: Jun, 1999. 
AB  - Describes the conceptual design, research framework, evaluation components, and analytic strategies that are guiding the evaluation of the American Stop Smoking Intervention Study, which was initiated to prevent and reduce tobacco use primarily through policy-based approaches to alter the social-political environment. The evaluation is a unique analysis of the complex relationships between the social context, public health activity at the state level, tobacco use, and individual behavior. The measures of tobacco control activity developed for this evaluation may be useful in ongoing national cancer control surveillance efforts, and the lessons learned will enhance the development of tobacco control programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - conceptual design & research framework & components & analytic strategies for evaluation of American Stop Smoking Intervention Study
KW  - 1999
KW  - Methodology
KW  - Program Evaluation
KW  - Smoking Cessation
KW  - Tobacco Smoking
KW  - Concepts
KW  - Experimentation
KW  - Government Policy Making
KW  - Prevention
KW  - Strategies
KW  - 1999
DO  - 10.1177/0193841X9902300301
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1999-03230-001&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42599-027
AN  - 2015-42599-027
AU  - Behar, Toby N.
AU  - Scott, Catherine A.
AU  - Greene, Carolyn L.
AU  - Wen, Xiling
AU  - Smith, Susan V.
AU  - Maric, Dragan
AU  - Liu, Qi-Ying
AU  - Colton, Carol A.
AU  - Barker, Jeffery L.
T1  - Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/06//
VL  - 19
IS  - 11
SP  - 4449
EP  - 4461
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Behar, Toby N., Building 36, Room 2C02, 36 Convent Drive, Bethesda, MD, US, 20892-4066
N1  - Accession Number: 2015-42599-027. PMID: 10341246 Partial author list: First Author & Affiliation: Behar, Toby N.; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Cortex; Gamma Aminobutyric Acid; N-Methyl-D-Aspartate; Subventricular Zone. Minor Descriptor: Mice; Rats; Migration of Nerve Cells; AMPA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jun, 1999. Publication History: Accepted Date: Mar 22, 1999; Revised Date: Mar 15, 1999; First Submitted Date: Jan 6, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - During cortical development, embryonic neurons migrate from germinal zones near the ventricle into the cortical plate, where they organize into layers. Mechanisms that direct neuronal migration may include molecules that act as chemoattractants. In rats, GABA, which localizes near the target destination for migrating cortical neurons, stimulates embryonic neuronal migration in vitro. In mice, glutamate is highly localized near the target destinations for migrating cortical neurons. Glutamate-induced migration of murine embryonic cortical cells was evaluated in cell dissociates and cortical slice cultures. In dissociates, the chemotropic effects of glutamate were 10-fold greater than the effects of GABA, demonstrating that for murine cortical cells, glutamate is a more potent chemoattractant than GABA. Thus, cortical chemoattractants appear to differ between species. Micromolar glutamate stimulated neuronal chemotaxis that was mimicked by µM NMDA but not by other ionotropic glutamate receptor agonists (AMPA, kainate, quisqualate). Responding cells were primarily derived from immature cortical regions [ventricular zone (vz)/subventricular zone (svz)]. Bromodeoxyuridine (BrdU) pulse labeling of cortical slices cultured in NMDA antagonists (µM MK801 or APV) revealed that antagonist exposure blocked the migration of BrdU-positive cells from the vz/svz into the cortical plate. PCR confirmed the presence of NMDA receptor expression in vz/svz cells, whereas electrophysiology and Ca2+ imaging demonstrated that vz/svz cells exhibited physiological responses to NMDA. These studies indicate that, in mice, glutamate may serve as a chemoattractant for neurons in the developing cortex, signaling cells to migrate into the cortical plate via NMDA receptor activation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mouse
KW  - chemotaxis
KW  - cortex
KW  - development
KW  - slice
KW  - chemoattractant
KW  - 1999
KW  - Cerebral Cortex
KW  - Gamma Aminobutyric Acid
KW  - N-Methyl-D-Aspartate
KW  - Subventricular Zone
KW  - Mice
KW  - Rats
KW  - Migration of Nerve Cells
KW  - AMPA
KW  - 1999
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42600-027
AN  - 2015-42600-027
AU  - Maric, Dragan
AU  - Maric, Irina
AU  - Wen, Xiling
AU  - Fritschy, Jean-Marc
AU  - Sieghart, Werner
AU  - Barker, Jeffery L.
AU  - Serafini, Ruggero
T1  - GABAA receptor subunit composition and functional properties of Cl− channels with differential sensitivity to zolpidem in embryonic rat hippocampal cells.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/06//
VL  - 19
IS  - 12
SP  - 4921
EP  - 4937
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Maric, Dragan, Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 2C-02, Bethesda, MD, US, 20892
N1  - Accession Number: 2015-42600-027. PMID: 10366626 Partial author list: First Author & Affiliation: Maric, Dragan; Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hippocampus; Neural Receptors; Sedatives. Minor Descriptor: Gamma Aminobutyric Acid; Immunocytochemistry. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 17. Issue Publication Date: Jun, 1999. Publication History: Accepted Date: Apr 6, 1999; Revised Date: Apr 1, 1999; First Submitted Date: Dec 4, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Using flow cytometry in conjunction with a voltage-sensitive fluorescent indicator dye (oxonol), we have identified and separated embryonic hippocampal cells according to the sensitivity of their functionally expressed GABAA receptors to zolpidem. Immunocytochemical and RT-PCR analysis of sorted zolpidem-sensitive (ZS) and zolpidem-insensitive (ZI) subpopulations identified ZS cells as postmitotic, differentiating neurons expressing α2, α4, α5, β1, β2, β3, γ1, γ2, and γ3 GABAA receptor subunits, whereas the ZI cells were neuroepithelial cells or newly postmitotic neurons, expressing predominantly α4, α5, β1, and γ2 subunits. Fluctuation analyses of macroscopic Cl- currents evoked by GABA revealed three kinetic components of GABAA receptor/Cl- channel activity in both subpopulations. We focused our study on ZI cells, which exhibited a limited number of subunits and functional channels, to directly correlate subunit composition with channel properties. Biophysical analyses of GABA-activated Cl- currents in ZI cells revealed two types of receptor-coupled channel properties: one comprising short-lasting openings, high affinity for GABA, and low sensitivity to diazepam, and the other with long-lasting openings, low affinity for GABA, and high sensitivity to diazepam. Both types of channel activity were found in the same cell. Channel kinetics were well modeled by fitting dwell time distributions to biliganded activation and included two open and five closed states. We propose that short- and long-lasting openings correspond to GABAA receptor/Cl- channels containing α4β1γ2 and α5β1γ2 subunits, respectively. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GABAA receptors
KW  - zolpidem
KW  - oxonol
KW  - FACS
KW  - development
KW  - rat
KW  - hippocampus
KW  - 1999
KW  - Hippocampus
KW  - Neural Receptors
KW  - Sedatives
KW  - Gamma Aminobutyric Acid
KW  - Immunocytochemistry
KW  - 1999
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42600-028
AN  - 2015-42600-028
AU  - Wang, Hao
AU  - Copeland, Neal G.
AU  - Gilbert, Debra J.
AU  - Jenkins, Nancy A.
AU  - Tessier-Lavigne, Marc
T1  - Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/06//
VL  - 19
IS  - 12
SP  - 4938
EP  - 4947
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Tessier-Lavigne, Marc, Department of Anatomy, University of California, 513 Parnassus Avenue, Room S-1479, San Francisco, CA, US, 94143-0452
N1  - Accession Number: 2015-42600-028. PMID: 10366627 Partial author list: First Author & Affiliation: Wang, Hao; Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wang, Hao. Major Descriptor: Ganglia; Genes; Peripheral Nervous System; Sensory Neurons. Minor Descriptor: Axons; Chromosomes; Mice. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Jun, 1999. Publication History: Accepted Date: Apr 7, 1999; Revised Date: Apr 2, 1999; First Submitted Date: Jan 7, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - [Correction Notice: An Erratum for this article was reported in Vol 19(19) of The Journal of Neuroscience (see record [rid]2015-43850-046[/rid]). In the original article, on page 4939, in Figure 1, 'mouse netrin-2' should read 'mouse netrin-3.' In Figure 1 legend, 'GenBank accession number: AF152418' should be added at the end of the legend. In the first sentences on page 4944 and in Figure 9 legend on page 4946, ' 120 μ/ml' should read ' 120 ng/ml.'] The netrins comprise a small phylogenetically conserved family of guidance cues important for guiding particular axonal growth cones to their targets. Two netrin genes, netrin-1 and netrin-2, have been described in chicken, but in mouse so far a single netrin gene, an ortholog of chick netrin-1, has been reported. We report the identification of a second mouse netrin gene, which we name netrin-3. Netrin-3 does not appear to be the ortholog of chick netrin-2 but is the ortholog of a recently identified human netrin gene termed NTN2L ('netrin-2-like'), as evidenced by a high degree of sequence conservation and by chromosomal localization. Netrin-3 is expressed in sensory ganglia, mesenchymal cells, and muscles during the time of peripheral nerve development but is largely excluded from the CNS at early stages of its development. The murine netrin-3 protein binds to netrin receptors of the DCC (deleted in colorectal cancer) family [DCC and neogenin] and the UNC5 family (UNC5H1, UNC5H2 and UNC5H3). Unlike chick netrin-1, however, murine netrin-3 binds to DCC with lower affinity than to the other four receptors. Consistent with this finding, although murine netrin-3 can mimic the outgrowth-promoting activity of netrin-1 on commissural axons, it has lower specific activity than netrin-1. Thus, like netrin-1, netrin-3 may also function in axon guidance during development but may function predominantly in the development of the peripheral nervous system and may act primarily through netrin receptors other than DCC. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - netrin-3
KW  - axon guidance
KW  - sensory neurons
KW  - mouse chromosome 17
KW  - peripheral nervous system
KW  - DCC
KW  - 1999
KW  - Ganglia
KW  - Genes
KW  - Peripheral Nervous System
KW  - Sensory Neurons
KW  - Axons
KW  - Chromosomes
KW  - Mice
KW  - 1999
U1  - Sponsor: American Cancer Society, US. Recipients: Wang, Hao
U1  - Sponsor: National Institutes of Health, US. Recipients: Tessier-Lavigne, Marc
U1  - Sponsor: US Department of Health and Human Services, National Cancer Institute, US. Other Details: Under contract with Advanced Bioscience Laboratories. Recipients: Copeland, Neal G.; Gilbert, Debra J.; Jenkins, Nancy A.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-42600-031
AN  - 2015-42600-031
AU  - Pozzo-Miller, Lucas D.
AU  - Gottschalk, Wolfram
AU  - Zhang, Li
AU  - McDermott, Kathryn
AU  - Du, Jing
AU  - Gopalakrishnan, Raj
AU  - Oho, Chikara
AU  - Sheng, Zu-Hang
AU  - Lu, Bai
T1  - Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/06//
VL  - 19
IS  - 12
SP  - 4972
EP  - 4983
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Pozzo-Miller, Lucas D., Department of Neurobiology, University of Alabama at Birmingham, CIRC 429-A2, 1719 Sixth Avenue South, Birmingham, AL, US, 35294-0021
N1  - Accession Number: 2015-42600-031. PMID: 10366630 Partial author list: First Author & Affiliation: Pozzo-Miller, Lucas D.; Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke (NINDS), National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hippocampus; Neurotransmission; Brain Derived Neurotrophic Factor; Synaptic Vesicle. Minor Descriptor: Mice; Synapses; Long-term Potentiation. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Jun, 1999. Publication History: Accepted Date: Apr 5, 1999; Revised Date: Mar 16, 1999; First Submitted Date: Jan 20, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS). Here we have investigated the mechanisms of BDNF action using two lines of BDNF knockout mice. Among other presynaptic impairments, the mutant mice exhibited more pronounced synaptic fatigue at CA1 synapses during high-frequency stimulation, compared with wild-type animals. Quantitative analysis of CA1 synapses revealed a significant reduction in the number of vesicles docked at presynaptic active zones in the mutant mice. Synaptosomes prepared from the mutant hippocampus exhibited a marked decrease in the levels of synaptophysin as well as synaptobrevin [vesicle-associated membrane protein (VAMP-2)], a protein known to be involved in vesicle docking and fusion. Treatment of the mutant slices with BDNF reversed the electrophysiological and biochemical deficits in the hippocampal synapses. Taken together, these results suggest a novel role for BDNF in the mobilization and/or docking of synaptic vesicles to presynaptic active zones. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - BDNF
KW  - knockout mice
KW  - hippocampus
KW  - synaptic fatigue
KW  - vesicle docking
KW  - synaptobrevin
KW  - synaptophysin
KW  - 1999
KW  - Hippocampus
KW  - Neurotransmission
KW  - Brain Derived Neurotrophic Factor
KW  - Synaptic Vesicle
KW  - Mice
KW  - Synapses
KW  - Long-term Potentiation
KW  - 1999
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107213655
T1  - Time of implantation of the conceptus and loss of pregnancy.
AU  - Wilcox AJ
AU  - Baird DD
AU  - Weinberg CR
Y1  - 1999/06/10/
N1  - Accession Number: 107213655. Language: English. Entry Date: 19991001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Fertilization
KW  - Abortion, Spontaneous
KW  - Time Factors
KW  - P-Value
KW  - Risk Factors
KW  - Pregnancy
KW  - Female
KW  - Human
SP  - 1796
EP  - 1799
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 340
IS  - 23
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Epidemiology Branch, MD A3-05, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
U2  - PMID: 10362823.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107213655&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kang, S.H.
AU  - Bang, Y.-J.
AU  - Jong, H.-S.
AU  - Seo, J.Y.
AU  - Kim, N.K.
AU  - Kim, S.-J.
T1  - Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells.
JO  - British Journal of Cancer
JF  - British Journal of Cancer
Y1  - 1999/06/15/
VL  - 80
IS  - 8
M3  - Article
SP  - 1144
PB  - Nature Publishing Group
SN  - 00070920
AB  - Transforming growth factor-β (TGF-β) is a multifunctional polypeptide that inhibits cellular proliferation in most epithelial cells. cdk4 and several cyclin-dependent kinase (cdk) inhibitors (p15INK4B, p21WAF1/Cip1 and p27Kip1) have been implicated in the TGF-β-induced cell cycle arrest. More recently, down-regulation of Cdc25A, a cdk activator, was additionally suggested as a mechanism underlying growth inhibition by TGF-β. The existence of diverse cellular mediators of TGF-β, however, raises the question of whether their involvement might occur in a redundant manner or coordinately in a certain cell type. Using two TGF-β-sensitive gastric carcinoma cell lines (SNU-16 and -620), we addressed the contributory roles of several cdk inhibitors, and of cdk4 and Cdc25A, in TGF-β-induced cell cycle arrest by comparing their temporal expression pattern in response to TGF-β. Among the cdk inhibitors examined, p21 mRNA was most rapidly (in less than 1 h) and prominently induced by TGF-β. In contrast, p15 mRNA was more slowly induced than p21 in SNU-620 cells, and not expressed in SNU-16 cells harbouring homozygous deletion of p15. Western blotting results confirmed the rapid increase of p21, while opposite patterns of p27 expression were observed in the two cell lines. The down-regulation of Cdc25A mRNA occurred, but was more delayed than that of p15 or p21. Until G1 arrest was established, changes in the protein levels of both Cdc25A and cdk4 were marginal. Co-immunoprecipitation with anti-cdk4 antibody showed that induced p21 associates with cdk4 and that its kinase activity is reduced by TGF-β, which kinetically correlates closely with G1 arrest following TGF-β treatment of both cell lines. These results suggest that in certain human epithelial cells, p21 may play an early role in TGF-β-induced cell cycle arrest, and its cooperation with other cdk inhibitors is different depending on cell type. Delayed down-regulation of Cdc25A and cdk4 may contribute to cell adaptation to the quiescent state in the two gastric carcinoma cell lines studied. © 1999 Cancer Research Campaign [ABSTRACT FROM AUTHOR]
AB  - Copyright of British Journal of Cancer is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELL cycle
KW  - CYCLIN-dependent kinases
KW  - CANCER cells
KW  - cdc25a
KW  - cdk inhibitors
KW  - cell cycle arrest
KW  - gastric cancer cells
KW  - p21waf1
KW  - tgf-&beta
N1  - Accession Number: 11343524; Kang, S.H. 1 Bang, Y.-J. 1,2 Jong, H.-S. 1 Seo, J.Y. 1 Kim, N.K. 1,2 Kim, S.-J. 3; Affiliation:  1: Cancer Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea  2: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea  3: Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethasda, MD 20892-5055, USA; Source Info: 6/15/99, Vol. 80 Issue 8, p1144; Subject Term: CELL cycle; Subject Term: CYCLIN-dependent kinases; Subject Term: CANCER cells; Author-Supplied Keyword: cdc25a; Author-Supplied Keyword: cdk inhibitors; Author-Supplied Keyword: cell cycle arrest; Author-Supplied Keyword: gastric cancer cells; Author-Supplied Keyword: p21waf1; Author-Supplied Keyword: tgf-&beta; Number of Pages: 6p; Document Type: Article
L3  - 10.1038/sj.bjc.6690478
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Huang, Shu-zhen
AU  - Zeng, Fan-yi
AU  - Chen, Mei-jue
AU  - Ren, Zhao-rui
AU  - Shen, Min
AU  - Rodgers, Griffin P.
AU  - Schechter, Alan N.
AU  - Zeng, Yi-tao
T1  - The Delta-Globin RNA Transcript Level in Beta-Thalassemia Carriers.
JO  - Acta Haematologica
JF  - Acta Haematologica
Y1  - 1999/07//
VL  - 102
IS  - 1
M3  - Article
SP  - 1
EP  - 6
SN  - 00015792
AB  - Increased levels of hemoglobin A[sub 2] (HbA[sub 2] ) are present in most β-thalassemia carriers. The mechanism of this effect is not understood, although the increase may result from transcriptional and posttranscriptional changes. In the present study, we quantitate δ-globin mRNA levels in peripheral-blood-enriched reticulocytes and characterize the variation of δ-mRNA levels in 30 β-thalassemia heterozygotes who individually carry one of the four common Chinese β-thalassemia alleles [codons 41/42 (–TTCT); codon 17 (A→T); IVS-II-654 (C→T); –28 (A→G)]. A sensitive and quantitative competitive reverse-transcriptase polymerase chain reaction method was developed and used to assess the absolute amounts of δ-mRNA transcripts in these peripheral erythroid cells. The results showed a large increase in δ-mRNA amounts in all the carriers examined (72.3 ± 9.0 amol/μg RNA) as compared with those in 12 controls (1.2 ± 0.2 amol/ μg RNA). There was a direct correlation between the δ-mRNA levels and types of β-thalassemia alleles; generally, the δ-mRNA levels are higher in heterozygotes for β[sup 0] -thalassemia mutations than β[sup +] -thalassemia mutations. The δ-mRNA levels correlated inversely with hemoglobin and red cell indices but directly with HbA[sub 2] levels in heterozygotes of each of the group of β-thalassemia mutations. These results suggest that a greater impairment in β-globin gene expression results in increased transcription of δ-globin gene and in a higher level of HbA[sub 2] . [ABSTRACT FROM AUTHOR]
AB  - Copyright of Acta Haematologica is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GLOBIN genes
KW  - HEMOGLOBIN
KW  - MESSENGER RNA
KW  - THALASSEMIA
KW  - RETICULOCYTES
KW  - β-Thalassemia
KW  - δ-Globin gene
KW  - HbA
KW  - Heterozygote
KW  - mRNA
N1  - Accession Number: 11333278; Huang, Shu-zhen 1,2 Zeng, Fan-yi 1,2 Chen, Mei-jue 1 Ren, Zhao-rui 1 Shen, Min 1 Rodgers, Griffin P. 2 Schechter, Alan N. 2 Zeng, Yi-tao 1; Affiliation:  1: Shanghai Institute of Medical Genetics, Shanghai Children’s Hospital, Shanghai, China  2: Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md., USA; Source Info: 1999, Vol. 102 Issue 1, p1; Subject Term: GLOBIN genes; Subject Term: HEMOGLOBIN; Subject Term: MESSENGER RNA; Subject Term: THALASSEMIA; Subject Term: RETICULOCYTES; Author-Supplied Keyword: β-Thalassemia; Author-Supplied Keyword: δ-Globin gene; Author-Supplied Keyword: HbA; Author-Supplied Keyword: Heterozygote; Author-Supplied Keyword: mRNA; Number of Pages: 6p; Document Type: Article
L3  - 10.1159/000040959
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 104720043
T1  - HIV and HCV infection among drug users in Japan.
AU  - Wada, K
AU  - Greberman, S B
AU  - Konuma, K
AU  - Hirai, S
Y1  - 1999/07//
N1  - Accession Number: 104720043. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118. 
KW  - HIV Infections -- Epidemiology
KW  - Hepatitis C -- Epidemiology
KW  - Substance Use Disorders -- Epidemiology
KW  - Adult
KW  - Alcoholism -- Epidemiology
KW  - Analysis of Variance
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Japan
KW  - Male
KW  - Middle Age
KW  - Needle Sharing
KW  - Self-Injurious Behavior
KW  - Sexuality
KW  - Solvents
KW  - Tattooing
SP  - 1063
EP  - 1069
JO  - Addiction
JF  - Addiction
JA  - ADDICTION
VL  - 94
IS  - 7
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - To assess seroprevalence of human immunodeficiency virus (HIV), hepatitis C virus, injecting drug use, unsafe sexual behaviours, self-mutilation and tattoos in patients attending a drug and alcohol treatment centre in Japan. Cross-sectional survey. The work was carried out at the National Sanitarium of Shimousa, Chiba, Japan, a 32-bed inpatient centre specializing in drug and alcohol treatment. Laboratory analyses for HIV antibody, hepatitis C antibody, hepatitis B antigen and antibody; questionnaires for history of sexual activities, needle and syringe use; physical examination with assessment of self-amputated finger joints, tattoos, scars from lacerations and cigarette burns. No patients tested positive for anti-HIV. The seroprevalence of anti-HCV positives was 53.8% of methamphetamine-dependent patients, 18.4% of solvent-dependent patients and 5.6% of alcohol-dependent patients. Past needle sharing was reported by 82.1% of methamphetamine-dependent patients, 18.4% of solvent-dependent patients and 5.6% of alcohol-dependent patients. A history of syringe sharing was reported by 87.2% of methamphetamine-dependent patients. More than two-thirds of all patients reported contact with commercial sex workers. Casual sexual contacts were more common among solvent and methamphetamine-dependent patients than those dependent on alcohol. Tattoos and cigarette burns were more common among methamphetamine and solvent-dependent patients than among alcohol-dependent patients. Among the methamphetamine-dependent patients, 20.5% reported self-amputated finger joints compared with none in the other patient groups. HCV prevalence is a significant problem among methamphetamine users in Japan, probably because of a high rate of needle and/or syringe sharing. Although HIV infection is currently negligible, the very high rate of needle and syringe sharing could give rise to a significant increase in the HIV rate among drug users in the future.
SN  - 0965-2140
AD  - National Center of Neurology and Psychiatry, National Institute of Mental Health, Chiba, Japan.
U2  - PMID: 10707444.
DO  - 10.1046/j.1360-0443.1999.947106311.x
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107227248
T1  - Energy metabolism in African Americans: potential risk factors for obesity...including commentary by Kumanyika SK
AU  - Weyer C
AU  - Snitker S
AU  - Bogardus C
AU  - Ravussin E
Y1  - 1999/07//
N1  - Accession Number: 107227248. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; commentary; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027. 
KW  - Energy Metabolism
KW  - Race Factors
KW  - Blacks
KW  - Whites
KW  - Basal Metabolic Rate -- Evaluation
KW  - Hydrodensitometry
KW  - Adipose Tissue Distribution
KW  - Body Composition -- Evaluation
KW  - Body Weights and Measures
KW  - Biophysiological Methods
KW  - Physical Activity -- Evaluation
KW  - Oxygen Consumption -- Evaluation
KW  - Nitrogen -- Urine
KW  - Comparative Studies
KW  - Descriptive Statistics
KW  - Regression
KW  - Multiple Linear Regression
KW  - Data Analysis Software
KW  - Analysis of Covariance
KW  - Respiration
KW  - Age Factors
KW  - Sex Factors
KW  - Diet
KW  - Carbon Dioxide
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 13
EP  - 2
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 70
IS  - 1
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Background: Recent reports have identified a lower resting metabolic rate in African Americans than in whites, but most studies included only females and used short-term measurements with ventilated-hood systems. Objective: Our objective was to compare 24-h measurements of energy metabolism between African American and white women and men using a respiratory chamber. Design: Thirty-eight African American (chi +/= SD: 32 +/= 7 y of age, 24 +/= 10% body fat) and 288 white (31 +/= 7 y of age, 26 +/= 12% body fat) subjects spent 24 h in a respiratory chamber for measurement of 24-h energy expenditure (24EE), sleeping metabolic rate (SMR), 24-h respiratory quotient (24RQ), and substrate oxidation rates. Results: After adjustment for sex, age, and body composition (by hydrodensitometry), African Americans had lower SMR (-301 +/= 105 kJ/d; P < 0.01) and higher 24RQ (0.014 +/= 0.004; P < 0.001) than whites, whereas 24EE was similar. A sex-specific analysis, using a subset of 38 whites with an equal sex distribution and similar age and body weight, revealed that African American women had lower SMR (-442 +/= 182 kJ/d; P < 0.05) and lower 24EE (-580 +/= 232 kJ/d; P < 0.05), but similar 24RQ values compared with white women. African American men tended to have lower SMRs than white men (-355 +/= 188 kJd; P = 0.07), but had higher 24RQ values, accounting for a 992 +/= 327-kJ/d lower 24-h fat oxidation rate (P < 0.005). Conclusions: These data not only confirm the findings of a lower metabolic rate in African American than in white women, but also suggest that fat oxidation is lower in African American men than in white men. Copyright 1999 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 North 16th Street, Room 5-41, Phoenix, AZ 85016. E-mail: cweyer@phx.niddk.nih.gov
U2  - PMID: 10393133.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Northridge, Mary E.
AU  - Yankura, Joanne
AU  - Kinney, Patrick L.
AU  - Santella, Regina M.
AU  - Shepard, Peggy
AU  - Riojas, Ynolde
AU  - Aggarwal, Maneesha
AU  - Strickland, Paul
T1  - Diesel Exhaust Exposure Among Adolescents in Harlem: A Community-Driven Study.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/07//
VL  - 89
IS  - 7
M3  - Article
SP  - 998
EP  - 102
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study sought individual-level data on diesel exhaust exposure and lung function among adolescents in Harlem as part of a community-driven research agenda. Methods. High school students administered in-person surveys to, seventh grade students to ascertain information on demographics, asthma history, and self-reported and maternal smoking Urine samples were assayed for 1-hydroxypyrene (1-HP), a marker of diesel exhaust exposure, and cotinine, a marker of tobacco smoke exposure Computer-assisted spirometry was used to measure lung function. Results Three quarters (76%) of the participating students had detectable levels of 1-HP Three students (13%) had an FEP25-75 of less than or equal to 80% of their predicted measurements, and 4 students (17%) had results between 80% and 90% of the predicted value, all of which are suggestive of possible lung impairment. Conclusions. These data suggest that most adolescents in Harlem ate exposed to detectable levels of diesel exhaust, a known exacerbator and possible cause of chrome lung disorders such as asthma Community-driven research initiatives are important for empowering communities to make needed changes to improve their environments and health. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIESEL motor exhaust gas
KW  - ASTHMA
KW  - HEALTH surveys
KW  - SMOKING
KW  - LUNG diseases
KW  - HARLEM (New York, N.Y.)
N1  - Accession Number: 2009953; Northridge, Mary E. 1,2; Email Address: men11@columbia.edu Yankura, Joanne 1 Kinney, Patrick L. 2 Santella, Regina M. 2 Shepard, Peggy 3 Riojas, Ynolde 2 Aggarwal, Maneesha 2 Strickland, Paul 4; Affiliation:  1: Harlem Center for Health Promotion and Disease Prevention, New York, NY  2: National Institute of Environmental Health Sciences (NIEHS) Center for Environmental Health in Northern Manhattan, New York, NY  3: West Harlem Environmental Action, New York, NY  4: Johns Hopkins School of Hygiene and Public Health, Baltimore, Md.; Source Info: Jul99, Vol. 89 Issue 7, p998; Subject Term: DIESEL motor exhaust gas; Subject Term: ASTHMA; Subject Term: HEALTH surveys; Subject Term: SMOKING; Subject Term: LUNG diseases; Subject Term: HARLEM (New York, N.Y.); Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Alavanja, Michael C. R.
AU  - Lubin, Jay H.
AU  - Mahaffey, Judith A.
AU  - Brownson, Ross C.
T1  - Residential Radon Exposure and Risk of Lung Cancer in Missouri.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/07//
VL  - 89
IS  - 7
M3  - Article
SP  - 1042
EP  - 1048
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives This study investigated residential radon exposure and lung cancer risk, using both standard radan dosimetry and a new radon monitoring technology that, evidence suggest, is a better measure of cumulative randon exposure. Methods. Missouri women (aged 30 to 84 years) newly diagnosed with primary lung cancer during the period January 1, 1993, to January 31, 1994, were invited to participate in this population-based case-control study. Both indoor air radon detectors and CR-39 alpha-particle detectors (surface monitors) were used. Results. When surface monitors were use, a significant trend in lung cancer odds ratios was observed in 20-year time-weighted-avenge radon concentrations. Conclusions. When surface monitors were used but not when standard radon dosimetry was used a significant lung cancer risk was found for radon concentrations at and above the action level for migration of houses currently used in the United States (148 Bqm-3). The risk a below the action level used in Canada (750 Bqm-3) and many European countries. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - RADON
KW  - LUNGS -- Cancer
KW  - CANCER in women
KW  - HEALTH risk assessment
KW  - WOMEN -- Diseases
KW  - MISSOURI
N1  - Accession Number: 2009961; Alavanja, Michael C. R. 1 Lubin, Jay H. 1 Mahaffey, Judith A. 2 Brownson, Ross C. 3; Affiliation:  1: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md.  2: Pacific Northwest Laboratories, Battelle Memorial Institute, Joe, Richland, Wash.  3: Department of Community Health, School of Public Health, St. Louis University, St. Louis, Mo.; Source Info: Jul99, Vol. 89 Issue 7, p1042; Subject Term: RADON; Subject Term: LUNGS -- Cancer; Subject Term: CANCER in women; Subject Term: HEALTH risk assessment; Subject Term: WOMEN -- Diseases; Subject Term: MISSOURI; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107145768
T1  - Diesel exhaust exposure among adolescents in Harlem: a community-driven study.
AU  - Northridge ME
AU  - Yankura J
AU  - Kinney PL
AU  - Santella RM
AU  - Shepard P
AU  - Riojas Y
AU  - Aggarwal M
AU  - Strickland P
Y1  - 1999/07//
N1  - Accession Number: 107145768. Corporate Author: Earth Crew. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: NIEHS Center for Environmental Health in Northern Manhattan and supported in part by DHHS Center Grant P30-ES03819 at the Johns Hopkins School of Public Health. NLM UID: 1254074. 
KW  - Motor Vehicles -- Adverse Effects
KW  - Air Pollutants -- Adverse Effects
KW  - Environmental Exposure -- Adverse Effects -- In Adolescence
KW  - Funding Source
KW  - Epidemiological Research
KW  - Hydrocarbons, Aromatic -- Urine
KW  - Cotinine -- Urine
KW  - Interviews
KW  - Urinalysis
KW  - Spirometry
KW  - Questionnaires
KW  - Immunoassay
KW  - Data Analysis Software
KW  - Descriptive Statistics
KW  - New York
KW  - Asthma -- Epidemiology
KW  - Smoking -- Epidemiology
KW  - Child
KW  - Adolescence
KW  - Male
KW  - Female
KW  - Human
SP  - 998
EP  - 1002
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 89
IS  - 7
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study sought individual-level data on diesel exhaust exposure and lung function among adolescents in Harlem as part of a community-driven research agenda. METHODS: High school students administered in-person surveys to seventh grade students to ascertain information on demographics, asthma history, and self-reported and maternal smoking. Urine samples were assayed for 1-hydroxypyrene (1-HP), a marker of diesel exhaust exposure, and cotinine, a marker of tobacco smoke exposure. Computer-assisted spirometry was used to measure lung function. RESULTS: Three quarters (76%) of the participating students had detectable levels of 1-HP. Three students (13%) had an FEF25-75 of less than or equal to 80% of their predicted measurements, and 4 students (17%) had results between 80% and 90% of the predicted value, all of which are suggestive of possible lung impairment. CONCLUSIONS: These data suggest that most adolescents in Harlem are exposed to detectable levels of diesel exhaust, a known exacerbator and possible cause of chronic lung disorders such as asthma. Community-driven research initiatives are important for empowering communities to make needed changes to improve their environments and health.
SN  - 0090-0036
AD  - National Institute of Environmental Health Sciences, Center for Environmental Health in Northern Manhattan, 60 Haven Ave, Level B-1, New York, NY 10032. E-mail: men11@columbia.edu
U2  - PMID: 10394306.
DO  - 10.2105/AJPH.89.7.998
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107145768&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107145796
T1  - Residential radon exposure and risk of lung cancer in Missouri.
AU  - Alavanja MCR
AU  - Lubin JH
AU  - Mahaffey JA
AU  - Brownson RC
Y1  - 1999/07//
N1  - Accession Number: 107145796. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Battelle Memorial Institute, Inc. contract N01-CP-21102. NLM UID: 1254074. 
KW  - Radon -- Adverse Effects
KW  - Lung Neoplasms -- Chemically Induced
KW  - Air Pollution, Indoor -- Adverse Effects
KW  - Radioactive Pollution -- Adverse Effects
KW  - Neoplasms, Radiation-Induced -- Etiology
KW  - Funding Source
KW  - Population-Based Case Control
KW  - Epidemiological Research
KW  - Registries, Disease
KW  - Interviews
KW  - Questionnaires
KW  - Maximum Likelihood
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Multiple Logistic Regression
KW  - P-Value
KW  - Missouri
KW  - Housing
KW  - Environmental Monitoring -- Methods
KW  - Radon -- Analysis
KW  - Lung Neoplasms -- Epidemiology
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 1042
EP  - 1048
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 89
IS  - 7
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study investigated residential radon exposure and lung cancer risk, using both standard radon dosimetry and a new radon monitoring technology that, evidence suggests, is a better measure of cumulative radon exposure. METHODS: Missouri women (aged 30 to 84 years) newly diagnosed with primary lung cancer during the period January 1, 1993, to January 31, 1994, were invited to participate in this population-based case-control study. Both indoor air radon detectors and CR-39 alpha-particle detectors (surface monitors) were used. RESULTS: When surface monitors were used, a significant trend in lung cancer odds ratios was observed for 20-year time-weighted-average radon concentrations. CONCLUSIONS: When surface monitors were used, but not when standard radon dosimetry was used, a significant lung cancer risk was found for radon concentrations at and above the action level for mitigation of houses currently used in the United States (148 Bqm-3). The risk was below the action level used in Canada (750 Bqm-3) and many European countries (200-400 Bqm-3).
SN  - 0090-0036
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 8000, Mail Stop 8000, Bethesda, MD 20892
U2  - PMID: 10394313.
DO  - 10.2105/AJPH.89.7.1042
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107147381
T1  - New ethics guidelines for epidemiology: background and rationale.
AU  - Weed DL
AU  - Coughlin SS
Y1  - 1999/07//1999 Jul
N1  - Accession Number: 107147381. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013. 
KW  - Epidemiology -- Ethical Issues
KW  - Practice Guidelines
KW  - Ethics, Medical
KW  - Medical Organizations
KW  - Professional Practice
SP  - 277
EP  - 280
JO  - Annals of Epidemiology
JF  - Annals of Epidemiology
JA  - ANN EPIDEMIOL
VL  - 9
IS  - 5
CY  - New York, New York
PB  - Elsevier Science
AB  - In the past decade, at least four sets of ethics guidelines for epidemiologists have been prepared by various national and international organizations. None, however, have been officially adopted by the American College of Epidemiology (ACE). Recently, the ACE asked its Ethics and Standards of Practice (ESOP) Committee to produce ethics guidelines. In this paper, we explain the context and rationale for this effort, describe the purpose and content of ethics guidelines in epidemiology, and discuss their strengths and weaknesses. Three issues that are central to the mission of ACE-education, policy, and advocacy-are inadequately addressed in existing ethics guidelines. In addition, ethics guidelines are not static documents; they should reflect the changing role of epidemiologists in society, including issues arising in emerging subspecialty areas. New, more dynamic, guidelines that emphasize core values, obligations, and virtues, may help to further define and legitimize the profession of epidemiology and will provide a foundation for the discussion of specific ethical issues in the classroom and in professional practice. Guidelines however, do not provide the final word on ethical issues. Specific decisions in particular cases require judgments made upon reflection of the core values, obligations, and virtues described in the guidelines. From our review, we conclude that a new set of guidelines is reasonable and warranted.
SN  - 1047-2797
AD  - National Cancer Institute, PES, Ste T-41, 6130 Executive Blvd MSC 7105, Bethesda, MD 20892-7105
U2  - PMID: 10976852.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107147381&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107219706
T1  - Where we work: National Institutes of Health, Warren Grant Magnuson Clinical Center.
AU  - Frattali CM
Y1  - 1999/07//Jul/Aug99
N1  - Accession Number: 107219706. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Allied Health; USA. NLM UID: 0370563. 
KW  - Health Facilities -- Maryland
KW  - Research, Medical
KW  - Speech-Language Pathology
KW  - National Institutes of Health (U.S.)
KW  - Maryland
KW  - Clinical Research
KW  - Rehabilitation
SP  - 46
EP  - 49
JO  - ASHA
JF  - ASHA
JA  - ASHA
VL  - 41
IS  - 4
CY  - Rockville, Maryland
PB  - American Speech-Language-Hearing Association
SN  - 0001-2475
AD  - Research Coordinator, Speech Language Pathology Section, W.G. Magnuson Clinical Center, NIH; e-mail: carol_frattali@nih.gov
U2  - PMID: 10420662.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107219706&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sabol, Sue Z.
AU  - Hamer, Dean H.
T1  - An Improved Assay Shows No Association Between the CYP2A6 Gene and Cigarette Smoking Behavior.
JO  - Behavior Genetics
JF  - Behavior Genetics
Y1  - 1999/07//
VL  - 29
IS  - 4
M3  - Article
SP  - 257
PB  - Springer Science & Business Media B.V.
SN  - 00018244
AB  - Pianezza et al. (1998) reported an association between the CYP2A6 gene, which codes for the enzyme that metabolizes nicotine to cotinine, and cigarette smoking behavior. We attempted to replicate their findings by analyzing the CYP2A6 gene in a population of 385 individuals using the same two-step PCR assay described by Pianezza et al. but found no association between genotype and either smoking status or cigarette consumption. We then developed a single-step PCR method that is specific for the CYP2A6 locus and eliminates a high rate of false-positive mutations detected by the two-step assay. Although this assay gave a much lower frequency of mutant alleles, there was again no association of CYP2A6 genotype with smoking behavior. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Behavior Genetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENES
KW  - SMOKING
KW  - BEHAVIOR genetics
KW  - cytochrome P450
KW  - nicotine
KW  - Smoking
N1  - Accession Number: 11304811; Sabol, Sue Z. 1 Hamer, Dean H. 1; Email Address: DeanH@helix.nih.gov; Affiliation:  1: Laboratory of Biochemistry, National Cancer Institute, Maryland; Source Info: Jul1999, Vol. 29 Issue 4, p257; Subject Term: GENES; Subject Term: SMOKING; Subject Term: BEHAVIOR genetics; Author-Supplied Keyword: cytochrome P450; Author-Supplied Keyword: nicotine; Author-Supplied Keyword: Smoking; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Berti, R.
AU  - Jacobson, S.
T1  - Role of Viral Infection in the Aetiology of Multiple Sclerosis: Status of Current Knowledge and Therapeutic Implications.
JO  - CNS Drugs
JF  - CNS Drugs
Y1  - 1999/07//
VL  - 12
IS  - 1
M3  - Article
SP  - 1
EP  - 7
PB  - Springer Science & Business Media B.V.
SN  - 11727047
AB  - Multiple sclerosis (MS) is a chronic disease of the CNS that typically begins in late adolescence or early adulthood. It is highly variable in its expression and severity. The cause of MS is unknown, but both genetic and environmental factors have been implicated in its pathogenesis. It is known that viruses can induce chronic neurological disease, but the pathogenetic process in unclear. A viral cause for MS has been postulated, but to date no single virus has been confirmed to be associated with the disease. Although most viral candidates are no longer considered as possible aetiological agents in MS, a few are still being investigated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of CNS Drugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MULTIPLE sclerosis
KW  - ADOLESCENCE
KW  - Immunosuppressants, pharmacodynamics
KW  - Multiple-sclerosis, pathogenesis
KW  - Reviews-on-disease
KW  - Reviews-on-treatment
KW  - Viral-infections
N1  - Accession Number: 9523370; Berti, R. 1 Jacobson, S. 1; Affiliation:  1: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 1999, Vol. 12 Issue 1, p1; Subject Term: MULTIPLE sclerosis; Subject Term: ADOLESCENCE; Author-Supplied Keyword: Immunosuppressants, pharmacodynamics; Author-Supplied Keyword: Multiple-sclerosis, pathogenesis; Author-Supplied Keyword: Reviews-on-disease; Author-Supplied Keyword: Reviews-on-treatment; Author-Supplied Keyword: Viral-infections; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Eissele, Rolf
AU  - Anlauf, Martin
AU  - Schäfer, Martin K. -H.
AU  - Eiden, Lee E.
AU  - Arnold, Rudolf
AU  - Weihe, Eberhard
T1  - Expression of Vesicular Monoamine Transporters in Endocrine Hyperplasia and Endocrine Tumors of the Oxyntic Stomach.
JO  - Digestion
JF  - Digestion
Y1  - 1999/07//
VL  - 60
IS  - 5
M3  - Article
SP  - 428
EP  - 439
SN  - 00122823
AB  - Background: Gastric enterochromaffin-like (ECL) cells selectively express the vesicular monoamine transporter (VMAT) VMAT2, and enterochromaffin (EC) cells the VMAT1 isoform. Aims: We investigated whether VMAT isoform selection indicates the origin of endocrine hyperplasia and neoplasia from oxyntic ECL or EC cells and may be of prognostic significance in different types of gastric carcinoids. Methods: Tissue from patients with chronic atrophic gastritis (CAG), Zollinger-Ellison-syndrome (ZES), gastric carcinoids and neuroendocrine carcinoma (NEC) was investigated by immunohistology and in situ hybridization. Results: Endocrine cells forming diffuse, linear, and micronodular hyperplasia in CAG and ZES, as well as oxyntic microcarcinoids expressed both VMAT2 and chromogranin A (CgA) but neither VMAT1 nor serotonin. In five of six sporadic carcinoids VMAT2 and CgA but not VMAT1 were detected. One carcinoid was copositive for VMAT1 and serotonin but negative for VMAT2. Electron microscopy confirmed the VMAT2-positive tumors as ECLoma and the VMAT1-immunoreactive carcinoid as EComa. Conclusions: VMAT2 and VMAT1 are reliable markers for differentiation of gastric endocrine hyperplasia and neoplasia from ECL and EC cells, respectively. The significance of VMAT2 and VMAT1 as prognostic markers lies in the relatively poor prognosis for EComa compared to ECLoma, characterized by VMAT2 positivity. The absence of both VMAT2 and VMAT1 in NEC may indicate poor prognosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Digestion is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HYPERPLASIA
KW  - CARCINOID
KW  - NEUROENDOCRINE tumors
KW  - GASTRITIS
KW  - GASTRIC diseases
KW  - Chronic atrophic gastritis
KW  - Gastric carcinoid
KW  - Neuroendocrine carcinoma
KW  - Vesicular monoamine transporter
KW  - Zollinger-Ellison syndrome
N1  - Accession Number: 11373011; Eissele, Rolf 1 Anlauf, Martin 2 Schäfer, Martin K. -H. 2 Eiden, Lee E. 3 Arnold, Rudolf 1 Weihe, Eberhard 2; Email Address: weihe@mailer.uni-marburg.de; Affiliation:  1: Department of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany  2: Department of Molecular Neuroimmunology, Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany  3: Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Md., USA; Source Info: 1999, Vol. 60 Issue 5, p428; Subject Term: HYPERPLASIA; Subject Term: CARCINOID; Subject Term: NEUROENDOCRINE tumors; Subject Term: GASTRITIS; Subject Term: GASTRIC diseases; Author-Supplied Keyword: Chronic atrophic gastritis; Author-Supplied Keyword: Gastric carcinoid; Author-Supplied Keyword: Neuroendocrine carcinoma; Author-Supplied Keyword: Vesicular monoamine transporter; Author-Supplied Keyword: Zollinger-Ellison syndrome; Number of Pages: 12p; Illustrations: 4 Color Photographs, 2 Black and White Photographs, 3 Charts; Document Type: Article
L3  - 10.1159/000007688
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Golding, Amit
AU  - Chandler, Simon
AU  - Ballestar, Esteban
AU  - Wolffe, Alan P.
AU  - Schlissel, Mark S.
T1  - Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/07//7/1/99
VL  - 18
IS  - 13
M3  - Article
SP  - 3712
EP  - 3723
SN  - 02614189
AB  - Lineage specificity and temporal ordering of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement are reflected in the accessibility of recombination signal sequences (RSSs) within chromatin to in vitro cleavage by the V(D)J recombinase. In this report, we investigated the basis of this regulation by testing the ability of purified RAG1 and RAG2 proteins to initiate cleavage on positioned nucleosomes containing RSS substrates. We found that nicking and double-strand DNA cleavage of RSSs positioned on the face of an unmodified nucleosome are entirely inhibited. This inhibition was independent of translational position or rotational phase and could not be overcome either by addition of the DNA-bending protein HMG-1 or by the use of hyperacetylated histones. We suggest that the nucleosome could act as the stable unit of chromatin which limits recombinase accessibility to potential RSS targets, and that actively rearranging gene segments might be packaged in a modified or disrupted nucleosome structure. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENES
KW  - PROTEINS
KW  - IMMUNOGLOBULINS
KW  - T cell receptors
KW  - DNA polymerases
KW  - accessibility
KW  - chromatin
KW  - nucleosome
KW  - v(d)j recombination
N1  - Accession Number: 13004162; Golding, Amit 1 Chandler, Simon 2 Ballestar, Esteban 2 Wolffe, Alan P. 1,3; Email Address: mss@uclink4.berkeley.edu Schlissel, Mark S.; Affiliation:  1: Johns Hopkins University School of Medicine, Department of Medicine, Department of Molecular Biology and Genetics, Baltimore, MD  2: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA  3: Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Source Info: 7/1/99, Vol. 18 Issue 13, p3712; Subject Term: GENES; Subject Term: PROTEINS; Subject Term: IMMUNOGLOBULINS; Subject Term: T cell receptors; Subject Term: DNA polymerases; Author-Supplied Keyword: accessibility; Author-Supplied Keyword: chromatin; Author-Supplied Keyword: nucleosome; Author-Supplied Keyword: v(d)j recombination; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/18.13.3712
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Albeck, D. S.
AU  - Bäckman, C.
AU  - Veng, L.
AU  - Friden, P.
AU  - Rose, G. M.
AU  - Granholm, A. -C. E.
T1  - Acute application of NGF increases the firing rate of aged rat basal forebrain neurons.
JO  - European Journal of Neuroscience
JF  - European Journal of Neuroscience
Y1  - 1999/07//
VL  - 11
IS  - 7
M3  - Article
SP  - 2291
EP  - 2304
PB  - Wiley-Blackwell
SN  - 0953816X
AB  - Abstract Nerve growth factor (NGF) has been widely used in animal models to ameliorate age-related neurodegeneration, but it cannot cross the blood–brain barrier (BBB). NGF conjugated to an antibody against the transferrin receptor (OX-26) crosses the BBB and affects the biochemistry and morphology of NGF-deprived basal forebrain neurons. The rapid actions of NGF, including electrophysiological effects on these neurons, are not well understood. In the present study, two model systems in which basal forebrain neurons either respond dysfunctionally to NGF (aged rats) or do not have access to target-derived NGF (intraocular transplants of forebrain neurons) were tested. One group of transplanted and one group of aged animals received unconjugated OX-26 and NGF comixture as a control, while other groups received replacement NGF in the form of OX-26–NGF conjugate during the 3 months preceding the electrophysiological recording session. Neurons from animals in both the transplanted and aged control groups showed a significant increase in firing rate in response to acute NGF application, while none of the conjugate-treated groups or young intact rats showed any response. After the recordings, forebrain transplants and aged brains were immunocytochemically stained for the low-affinity NGF receptor. All conjugate treatment groups showed significantly greater staining intensity compared to controls. These data from both transplants and aged rats in situ indicate that NGF-deprived basal forebrain neurons respond to acute NGF with an increased firing rate. This novel finding may have importance even for long-term biological effects of this trophic factor in the basal forebrain. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NERVE Growth Factor
KW  - PROSENCEPHALON
KW  - NEURODEGENERATION
KW  - acetylcholine
KW  - Alzheimer’s disease
KW  - medial septum
KW  - neurodegeneration
KW  - neurotrophins
N1  - Accession Number: 5185802; Albeck, D. S. 1,2 Bäckman, C. 3 Veng, L. 2 Friden, P. 4 Rose, G. M. 2,5 Granholm, A. -C. E. 1,2,5; Affiliation:  1: Department of Basic Science and Oral Research, University of Colorado Health Sciences Center, Denver, CO 80262, USA  2: Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA  3: National Institute on Drug Abuse, Intramural Res Program, Baltimore, MD 21224, USA  4: Peridontix, Watertown, MA 02172, USA  5: Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA; Source Info: Jul99, Vol. 11 Issue 7, p2291; Subject Term: NERVE Growth Factor; Subject Term: PROSENCEPHALON; Subject Term: NEURODEGENERATION; Author-Supplied Keyword: acetylcholine; Author-Supplied Keyword: Alzheimer’s disease; Author-Supplied Keyword: medial septum; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: neurotrophins; Number of Pages: 14p; Document Type: Article
L3  - 10.1046/j.1460-9568.1999.00644.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Li, Yong-Xin
AU  - Schaffner, Anne E.
AU  - Barker, Jeffery L.
T1  - Astrocytes regulate the developmental appearance of GABAergic and glutamatergic postsynaptic currents in cultured embryonic rat spinal neurons.
JO  - European Journal of Neuroscience
JF  - European Journal of Neuroscience
Y1  - 1999/07//
VL  - 11
IS  - 7
M3  - Article
SP  - 2537
EP  - 2551
PB  - Wiley-Blackwell
SN  - 0953816X
AB  - Abstract The effects of astrocytes on the emergence of synaptic transients and excitable membrane properties in cultured, embryonic, rat ventral spinal neurons were studied with electrical and optical recording techniques. Neurons on astrocytes had significantly longer neurites and an accelerated rate of growth in surface membrane during the initial 24 h in culture compared to neurons on poly-d-lysine (PDL). GABAergic (GABA, γ-aminobutyric acid) and glutamatergic transients appeared spontaneously in co-cultured neurons by 24 h. GABAergic quanta did not appear in neurons on PDL until 4 days in culture, and glutamatergic transients did not emerge until 7 days in culture. Astrocyte-conditioned medium (ACM) partially mimicked the effects of direct astrocytic contact. GABAergic transients appeared by 2 days, and glutamatergic signals by 4 days in neurons on PDL exposed to ACM. All of the spontaneous, synaptic-like transients were eliminated by tetrodotoxin or Ca2+o-free saline, implicating voltage-dependent cation channels in their generation. Astrocytes immediately and significantly increased the density of voltage-dependent Na+ currents compared to neurons on PDL, but by the end of 24 h, Na+ current densities were identical. Electrophysiological and optical recording revealed comparable densities of high-voltage-activated (HVA) Ca2+ currents on both co-cultured neurons and neurons on PDL throughout the first week. However, neurons on astrocytes had significantly greater contributions of P/Q-type currents and lesser contributions of L-type currents beginning at 24 h and continuing for 7 days. The contribution of N-type current was significantly more in co-cultured neurons only at 24 h. Thus, in vitro, astrocytes help to differentiate specific excitable membrane properties in spinal neurons, along with GABAergic and glutamatergic forms of synaptic transmission. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ASTROCYTES
KW  - SYNAPSES
KW  - SPINAL nerves
KW  - MOLECULES
KW  - PHYSIOLOGY
KW  - Ca
KW  - cell culture
KW  - differentiation
KW  - synapses
N1  - Accession Number: 5185774; Li, Yong-Xin Schaffner, Anne E. Barker, Jeffery L. 1; Affiliation:  1: Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Jul99, Vol. 11 Issue 7, p2537; Subject Term: ASTROCYTES; Subject Term: SYNAPSES; Subject Term: SPINAL nerves; Subject Term: MOLECULES; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: Ca; Author-Supplied Keyword: cell culture; Author-Supplied Keyword: differentiation; Author-Supplied Keyword: synapses; Number of Pages: 15p; Document Type: Article
L3  - 10.1046/j.1460-9568.1999.00679.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107219401
T1  - A multicomponent programme increased physical function and decreased hospital days in older adults with chronic disease...including commentary by Darzins PJ
AU  - Leveille SG
AU  - Wagner EH
AU  - Davis C
Y1  - 1999/07//1999 Jul-Aug
N1  - Accession Number: 107219401. Language: English. Entry Date: 19991001. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; commentary; research. Journal Subset: Biomedical; USA. Instrumentation: Health Assessment Questionnaire. NLM UID: 9608386. 
KW  - Primary Health Care -- In Old Age
KW  - Gerontologic Nurse Practitioners
KW  - Functional Status -- Trends -- In Old Age
KW  - Clinical Trials
KW  - Self Report
KW  - Research Instruments
KW  - P-Value
KW  - Geriatric Functional Assessment
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 113
EP  - 113
JO  - Evidence Based Medicine
JF  - Evidence Based Medicine
JA  - EVID BASED MED
VL  - 4
IS  - 4
PB  - BMJ Publishing Group
SN  - 1356-5524
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Suite 3C-309, Bethesda, MD 20892
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Feinendegen, L.E.
T1  - The role of adaptive responses following exposure to ionizing radiation.
JO  - Human & Experimental Toxicology
JF  - Human & Experimental Toxicology
Y1  - 1999/07//
VL  - 18
IS  - 7
M3  - Article
SP  - 426
EP  - 432
PB  - Sage Publications, Ltd.
SN  - 09603271
AB  - Discusses how the dose that induces the adaptive response (AR) relate to human and environmental exposures.  Definition of dose; Discussion on the absorption of the ionizing radiation; Meaning of dose rate.
KW  - Radiation
KW  - Ionizing radiation -- Dose-response relationship
N1  - Accession Number: 4664179; Feinendegen, L.E. 1; Affiliations: 1: Clinical Center National Institutes of Health, Department of Nuclear Medicine, Bethesda, Maryland, MD 20892, USA; Issue Info: 1999, Vol. 18 Issue 7, p426; Thesaurus Term: Radiation; Subject Term: Ionizing radiation -- Dose-response relationship; Number of Pages: 7p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 89522569
T1  - Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: results of an Italian Prostate Cancer Project study.
AU  - Boccardo, Francesco
AU  - Rubagotti, Alessandra
AU  - Barichello, Mario
AU  - Battaglia, Michele
AU  - Carmignani, Giorgio
AU  - Comeri, Giancarlo
AU  - Conti, Giario
AU  - Cruciani, Giorgio
AU  - Dammino, Sandro
AU  - Delliponti, Umberto
AU  - Ditonno, Pasquale
AU  - Ferraris, Valentino
AU  - Lilliu, Sergio
AU  - Montefiore, Franco
AU  - Portoghese, Filippo
AU  - Spano, Giovanni
AU  - Boccardo, F
AU  - Rubagotti, A
AU  - Barichello, M
AU  - Battaglia, M
Y1  - 1999/07//7/1/1999
N1  - Accession Number: 89522569. Language: English. Entry Date: 19991001. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Ferrans and Powers Quality of Life Index; Longitudinal Interval Follow-Up Evaluation (LIFE); Social Readjustment Rating Scale (SRRS) (Holmes and Rahe). NLM UID: 8309333. 
KW  - Antineoplastic Agents, Combined -- Therapeutic Use
KW  - Prostatic Neoplasms -- Drug Therapy
KW  - Amides -- Therapeutic Use
KW  - Antineoplastic Agents -- Therapeutic Use
KW  - Quality of Life
KW  - Organic Chemicals
KW  - Consumer Product Safety
KW  - Prostatic Neoplasms -- Mortality
KW  - Flutamide -- Administration and Dosage
KW  - Sulfur Compounds
KW  - Middle Age
KW  - Disease Progression
KW  - Aged, 80 and Over
KW  - Human
KW  - Prognosis
KW  - Impotence -- Chemically Induced
KW  - Italy
KW  - Cox Proportional Hazards Model
KW  - Antineoplastic Agents, Hormonal -- Administration and Dosage
KW  - Adult
KW  - Male
KW  - Survival
KW  - Impotence -- Epidemiology
KW  - Goserelin -- Administration and Dosage
KW  - Aged
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Randomized Controlled Trials
KW  - Ferrans and Powers Quality of Life Index
KW  - Social Readjustment Rating Scale
SP  - 2027
EP  - 2038
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade (MAB) in the treatment of advanced prostatic cancer.Patients and Methods: Previously untreated patients with histologically proven stage C or D disease (American Urological Association Staging System) were randomly allocated to receive either bicalutamide or MAB. After disease progression, patients treated with bicalutamide were assigned to castration. The primary end point for this trial was overall survival. Secondary end points included response to treatment, disease progression, treatment safety, quality-of-life (QOL), and sexual function.Results: A total of 108 patients received bicalutamide and 112 received MAB. There was no difference in the percentage of patients whose prostate-specific antigen returned to normal levels. At the time of the present analysis (median follow-up time, 38 months; range, 1 to 60 months), 129 patients progressed and 89 died. There was no difference in the duration of either progression-free survival or overall survival. However, a survival trend favored bicalutamide in stage C disease but MAB in stage D disease. Overall and subgroup trends were confirmed by multivariate analysis. Serious adverse events and treatment discontinuations were more common in patients receiving MAB (P =.08 and P =.04, respectively). Fewer patients in the bicalutamide group complained of loss of libido (P =. 01) and of erectile dysfunction (P =.002). Significant trends favored bicalutamide-treated patients also with respect to their QOL, namely relative to social functioning, vitality, emotional well-being, and physical capacity.Conclusion: Bicalutamide monotherapy yielded comparable results relative to standard treatment with MAB, induced fewer side effects, and produced a better QOL.
SN  - 0732-183X
AD  - Department of Medical Oncology and Biostatistics Unit, University and National Cancer Institute, Genoa
AD  - Department of Urology, University of Genoa, Genoa
AD  - Department of Urology, General Hospital, Venice
AD  - Department of Urology "R," University of Bari, Bari
AD  - Department of Urology, S. Anna Hospital, Como
AD  - Department of Oncology, Umberto I Hospital, Lugo di Romagna
AD  - Department of Urology, General Hospital, Caltagirone
AD  - Department of Urology, Santo Spirito Hospital, Casale Monferrato
AD  - Department of Urology, S. Michele Hospital, Cagliari
AD  - Department of Urology, General Hospital, Alessandria
AD  - Department of Urology, Regional Hospital, Acquaviva delle Fonti
AD  - Department of Urology, University of Sassari, Sassari, Italy
AD  - Department of Medical Oncology and Biostatistics Unit, University and National Cancer Institute, Genoa, Italy
U2  - PMID: 10561254.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89522571
T1  - Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect.
AU  - Childs, Richard W.
AU  - Clave, Emmanuel
AU  - Tisdale, John
AU  - Plante, Michelle
AU  - Hensel, Nancy
AU  - Barrett, John
AU  - Childs, R W
AU  - Clave, E
AU  - Tisdale, J
AU  - Plante, M
AU  - Hensel, N
AU  - Barrett, J
Y1  - 1999/07//7/1/1999
N1  - Accession Number: 89522571. Language: English. Entry Date: 19991001. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Hematopoietic Stem Cell Transplantation
KW  - Transplantation Immunology -- Immunology
KW  - Lung Neoplasms -- Therapy
KW  - Kidney Neoplasms -- Pathology
KW  - Carcinoma, Renal Cell -- Pathology
KW  - Lung Neoplasms
KW  - Allografts
KW  - Treatment Outcomes
KW  - Middle Age
KW  - Male
KW  - Antineoplastic Agents -- Therapeutic Use
KW  - Immunosuppressive Agents -- Therapeutic Use
KW  - Cyclophosphamide -- Therapeutic Use
KW  - Vidarabine -- Therapeutic Use
KW  - Vidarabine -- Analogs and Derivatives
KW  - Immunosuppression -- Methods
SP  - 2044
EP  - 2049
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: A 50-year-old man developed progressive pulmonary metastasis resistant to interferon alfa-2b treatment 7 months after he underwent left nephrectomy for stage III renal cell carcinoma. We performed a nonmyeloablative allogeneic peripheral-blood stem-cell transplant in this patient to exploit a possible graft-versus-tumor effect from allogeneic lymphocytes.Materials and Methods: The conditioning regimen consisted of fludarabine and cyclophosphamide followed by a T-cell replete, granulocyte-colony stimulating-factor-mobilized peripheral-blood stem-cell transplant from his HLA-identical brother. Cyclosporine was administered from days -4 to +45 to prevent graft rejection and acute graft-versus-host disease (GVHD).Results: Serial polymerase chain reaction analysis of hematopoietic lineage-specific minisatellites initiallyshowed mixed chimerism in CD14(+) and CD15(+) myeloid cells, CD3(+) T cells, and CD34(+) progenitor cells, with rapid conversion to 100% donor T-cell chimerism by day +60 and 100% donor myeloid cells by day +100. Serial computed tomography scans of the chest showed stable disease at day +30, slight regression of pulmonary lesions at day +63, and complete disappearance of all pulmonary metastatic disease by day +110. Mild transient acute GVHD disease of the skin occurred on day +60 and limited chronic GVHD of the skin occurred by day +200.Conclusion: The complete regression of metastatic disease, which has now been maintained for more than 1 year, is compatible with a graft-versus-tumor effect.
SN  - 0732-183X
AD  - Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD
AD  - Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
U2  - PMID: 10561256.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89522576
T1  - Gemcitabine as second-line treatment for advanced non-small-cell lung cancer: A phase II trial.
AU  - Crinñ, Lucio
AU  - Mosconi, Anna Maria
AU  - Scagliotti, Giorgio
AU  - Selvaggi, Giovanni
AU  - Novello, Silvia
AU  - Rinaldi, Massimo
AU  - Giulia, Marina Della
AU  - Gridelli, Cesare
AU  - Rossi, Antonio
AU  - Calandri, Cesare
AU  - De Marinis, Filippo
AU  - Noseda, Mariantonietta
AU  - Tonato, Maurizio
AU  - Crinò, L
AU  - Mosconi, A M
AU  - Scagliotti, G
AU  - Selvaggi, G
AU  - Novello, S
AU  - Rinaldi, M
AU  - Della Giulia, M
Y1  - 1999/07//7/1/1999
N1  - Accession Number: 89522576. Language: English. Entry Date: 19991001. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Deoxycytidine
KW  - Salvage Therapy -- Methods
KW  - Carcinoma, Non-Small-Cell Lung -- Drug Therapy
KW  - Antimetabolites, Antineoplastic -- Therapeutic Use
KW  - Lung Neoplasms -- Drug Therapy
KW  - Aged
KW  - Deoxycytidine -- Therapeutic Use
KW  - Human
KW  - Female
KW  - Lung Neoplasms -- Mortality
KW  - Male
KW  - Survival Analysis
KW  - Carcinoma, Non-Small-Cell Lung -- Mortality
KW  - Middle Age
KW  - Italy
KW  - Adult
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 2081
EP  - 2085
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To investigate the activity and toxicity of gemcitabine as a single agent in patients with advanced non-small-cell lung cancer (NSCLC) after recurrence or failure of previous treatment with a platinum-containing regimen.Patients and Methods: From November 1995 to October 1997, 83 patients with stage IIIB or IV NSCLC received gemcitabine 1,000 mg/m(2) once a week for 3 weeks every 28 days. Responses were assessed every two treatment courses. The median age of the patients was 63 years; Eastern Cooperative Oncology Group performance status was 0 to 1 in 62 patients and 2 in 21 patients. The predominant histology was squamous (39 patients); 49 patients had stage IV disease and 34 patients had stage III disease (33 stage IIIB and one stage IIIA).Results: Sixteen patients (19%) achieved a partial response to treatment; the median duration of response was 29 weeks (range, 6 to 50 weeks). Treatment was well tolerated: grade 2 to 3 (World Health Organization standardized response criteria) leukopenia and thrombocytopenia occurred in 23% and 20% of patients, respectively. Mild asthenia was observed in 16% of patients, and peripheral edema in 5% of patients. Nausea and vomiting were present in 16% of patients.Conclusion: In this experience, gemcitabine showed significant activity without relevant toxicity, mainly in patients who were previously responsive to chemotherapy. This suggests a possible role for gemcitabine as a second-line treatment in patients who had a previous response or achieved stable disease with a platinum-containing regimen.
SN  - 0732-183X
AD  - Medical Oncology Division, Policlinico Hospital, Perugia
AD  - Department of Clinical and Biological Sciences, University of Torino, Torino
AD  - Medical Oncology Division, Regina Elena, Rome
AD  - Medical Oncology B, National Cancer Institute G. Pascale, Naples
AD  - III Pneumology Division, Forlanini Hospital, Rome, Italy
AD  - Medical Oncology Division, Policlinico Hospital, Perugia, Italy
U2  - PMID: 10561261.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89522596
T1  - Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin.
AU  - Herman, Eugene H.
AU  - Jun Zhang
AU  - Lipshultz, Steven E.
AU  - Rifai, Nader
AU  - Chadwick, Douglas
AU  - Kazuyo Takeda
AU  - Zu-Xi Yu
AU  - Ferrans, Victor J.
AU  - Herman, E H
AU  - Zhang, J
AU  - Lipshultz, S E
AU  - Rifai, N
AU  - Chadwick, D
AU  - Takeda, K
AU  - Yu, Z X
AU  - Ferrans, V J
Y1  - 1999/07//7/1/1999
N1  - Accession Number: 89522596. Language: English. Entry Date: 19991001. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Wide Range Achievement Test (WRAT). NLM UID: 8309333. 
KW  - Doxorubicin
KW  - Drug Monitoring -- Methods
KW  - Myocardial Diseases -- Chemically Induced
KW  - Antineoplastic Agents
KW  - Myocardial Diseases -- Blood
KW  - Troponin -- Blood
KW  - Rats
KW  - Chronic Disease
KW  - Sensitivity and Specificity
KW  - Nonparametric Statistics
KW  - Myocardial Diseases -- Pathology
KW  - Male
KW  - Immunohistochemistry
KW  - Animals
KW  - Severity of Illness Indices
SP  - 2237
EP  - 2243
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 7
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To investigate, over a wide range of cumulative doxorubicin doses, the feasibility of using serum concentrations of cardiac troponin-T (cTnT) as a biomarker for doxorubicin-induced myocardial damage.Materials and Methods: Groups of spontaneously hypertensive rats (SHR) were given 1 mg/kg doxorubicin weekly for 2 to 12 weeks. Cardiomyopathy scores were assessed according to the method of Billingham and serum levels of cTnT were quantified by a noncompetitive immunoassay. Myocardial localization of cTnT was studied by immunohistochemical staining and confocal microscopy.Results: Increases in serum levels of cTnT (0.03 to 0.05 ng/mL) and myocardial lesions (cardiomyopathy scores of 1 or 1.5) were found in one out of five and two out of five SHR given 2 and 4 mg/kg doxorubicin, respectively. All animals given 6 mg/kg or more of doxorubicin had increases in serum cTnT and myocardial lesions. The average cTnT levels and the cardiomyopathy scores correlated with the cumulative dose of doxorubicin (0.13 v 0.4 ng/mL cTnT and scores of 1.4 v 3.0 in SHR given 6 and 12 mg/kg doxorubicin, respectively). Decreased staining for cTnT was observed in cardiac tissue from SHR receiving cumulative doses that caused only minimal histologic alterations (scores of 1 to 1.5). Staining for cTnT decreased simultaneously with increases in the severity of the cardiomyopathy scores.Conclusion: cTnT is released from doxorubicin-damaged myocytes. Measurements of serum levels of this protein seem to provide a sensitive means for assessing the early cardiotoxicity of doxorubicin.
SN  - 0732-183X
AD  - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD
AD  - Division of Pediatric Cardiology, University of Rochester Medical Center, Rochester, NY
AD  - Department of Laboratory Medicine, Boston Childrens Hospital and Harvard Medical School, Boston, MA
AD  - Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
AD  - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD 20708, USA
U2  - PMID: 10561281.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Childs, R. W.;
AU  - Clave, E.;
AU  - Tisdale, J.;
AU  - Plante, M.;
AU  - Barrett, J.;
AU  - \ET/;
T1  - Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect
CT  - Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect
JO  - Journal of Clinical Oncology (USA)
JF  - Journal of Clinical Oncology (USA)
Y1  - 1999/07/01/
VL  - 17
IS  - Jul
SP  - 2044
EP  - 2049
SN  - 0732183X
AD  - Hematol. Branch, Bldg. 10, Rm. 7C103, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA Internet: childsr@nih.gov
N1  - Accession Number: 37-09233; Language: English; Chemical Name: Interferon alfa-2b--99210-65-8 Interferon alfa-2b--99210-65-8; References: 22; Journal Coden: JCONDN; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ramune T. Dailide
N2  - The case of a 50 yr old man who developed progressive pulmonary metastasis resistant to treatment with interferon alfa-2b seven months after undergoing left nephrectomy for stage III renal cell carcinoma and who was the first patient to be treated with an investigational protocol in which he underwent nonmyeloablative allogeneic peripheral-blood stem-cell transplantation to exploit a possible graft-vs-tumor effect from allogeneic lymphocytes is presented. Concomitant therapy included various medications. The patient had complete resolution of progressive and extensive renal cell carcinoma after this novel transplant approach and has remained free of this carcinoma 15 months after transplantation.
KW  - Interferon alfa-2b--carcinoma-;
KW  - Antineoplastic agents--interferon alfa-2b--renal cell carcinoma;
KW  - Carcinoma--interferon alfa-2b--renal cell;
KW  - Transplantation--stem cells--renal cell carcinoma;
KW  - Carcinoma--transplantation--stem cells;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Yamamoto, Mokika
AU  - Iwata, Noboru
AU  - Tomado, Atsuko
AU  - Tanaka, Shiho
AU  - Fujimaki, Koori
AU  - Kitamura, Toshinori
T1  - Child emotional and physical maltreatment and adolescent psychopathology: A community study in Japan.
JO  - Journal of Community Psychology
JF  - Journal of Community Psychology
Y1  - 1999/07//
VL  - 27
IS  - 4
M3  - Article
SP  - 377
EP  - 391
PB  - John Wiley & Sons, Inc.
SN  - 00904392
AB  - The rate of different types of maltreatment of children younger than the age of 16 by parents was investigated among a sample of 119 Japanese nonconsulting adolescents. Emotional neglect, threat, putting to shame, slapping, punching with a fist, hitting with an implement, and burning by the father or the mother were reported to have occurred at least several times a year by 21.0%, 26.1%, 14.3%, 40.3%, 25.2%, 14.3%, and 0.8% of the participants, respectively. These figures were much higher than previous estimates from medical and social agency reports in Japan. Some associations were found between specific categories of child maltreatment and the lifetime prevalence of different types of DSM-III-R psychopathology. Among male adolescents, Generalized Anxiety Disorder was associated with being put to shame, punched, or hit with an implement by the mother, while chronic/recurrent Major Depression was associated with being put to shame by either the father or by the mother. Among female adolescents, chronic/recurrent Major Depression was associated with being emotionally neglected or threatened by the father and being slapped by the mother, while single-episode Major Depression was associated only with being slapped by the mother. These figures suggest that childhood maltreatment has effects on psychopathology among adolescents, particularly emotional maltreatment associated with chronic/recurrent Major Depression. © 1999 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD abuse
KW  - ADOLESCENT psychopathology
KW  - CHILD psychology
KW  - ABUSIVE parents
KW  - PARENT & child
KW  - JAPAN
N1  - Accession Number: 11771733; Yamamoto, Mokika 1 Iwata, Noboru 2 Tomado, Atsuko 3 Tanaka, Shiho 4 Fujimaki, Koori 5 Kitamura, Toshinori 6; Affiliation:  1: Yokohama International College of Social Welfare, Japan.  2: University of Occupational and Environmental Health, Kitakyushu, Japan.  3: Tokyo Metropolitan University, and Japanese Society for the Promotion of Science.  4: University of Tokyo.  5: Yokohama National University, Kanagawa, Japan.  6: National Institute of Mental Health, NCNP, Chiba, Japan.; Source Info: Jul1999, Vol. 27 Issue 4, p377; Subject Term: CHILD abuse; Subject Term: ADOLESCENT psychopathology; Subject Term: CHILD psychology; Subject Term: ABUSIVE parents; Subject Term: PARENT & child; Subject Term: JAPAN; Number of Pages: 15p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
AU  - Harper, Diane M.
AU  - Hildesheim, Allan
AU  - Cobb, Janet L.
AU  - Greenberg, Mitchell
AU  - Vaught, James
AU  - Lorincz, Attila T.
T1  - Collection Devices for Human Papillomavirus.
JO  - Journal of Family Practice
JF  - Journal of Family Practice
Y1  - 1999/07//
VL  - 48
IS  - 7
M3  - Article
SP  - 531
EP  - 535
SN  - 00943509
AB  - BACKGROUND. Human papillomavirus (HPV) testing has relied to date on samples collected by experienced health professionals. Self-administered testing devices could allow HPV testing to occur in large-scale  epidemiologic studies of primary care screening populations. The purpose of this study is to determine whether a  self-collection device for cervicovaginal HPV infection could be developed.  METHODS. A prospective randomized trial of a consecutive sampling of 93 women, 18 years or older, receiving routine cervical cancer screening and colposcopy in the urban gynecologic clinics in Philadelphia, Pennsylvania, were randomized into 2 arms. Women in arm 1 used a self-administered tampon before the physician-directed swabs of the cervix; in arm 2, women underwent the physician-directed swab testing before using the  self-administered tampon. The concordance of HPV DNA positivity between sampling methods detected by a Hybrid Capture HPV tube test for both low- and high-risk types of HPV was the main outcome measure.  RESULTS. The concordance rate (ie, women whose cultures were classified as negative on both tests or positive on both tests) for arms 1 and 2 were similar: 78.3% and 80.9%, respectively.  CONCLUSIONS. The tampon was equivalent to the physician-directed swab in HPV detection and suggests its feasibility in long-term primary care studies of screening populations. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PAPILLOMAVIRUSES
KW  - CERVIX uteri -- Diseases
KW  - PAPILLOMAVIRUS diseases
KW  - PRIMARY care (Medicine)
KW  - WOMEN -- Health
KW  - NUCLEIC acids
KW  - detection methods
KW  - human papillomavirus
KW  - hybrid capture [non-MESH]
KW  - Vaginal smears
N1  - Accession Number: 2853819; Harper, Diane M. 1; Email Address: Diane.M.Harper@Dartmouth.edu Hildesheim, Allan 2 Cobb, Janet L. 1 Greenberg, Mitchell 3 Vaught, James 4 Lorincz, Attila T. 5; Affiliation:  1: Dartmouth Medical School, Norris Cotton Cancer Center, Hanover, New Hampshire.  2: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.  3: OMNIA, Philadelphia, Pennsylvania.  4: MA BioServices, Rockville, Maryland.  5: Digene, Inc., Silver Spring, Maryland.; Source Info: Jul1999, Vol. 48 Issue 7, p531; Subject Term: PAPILLOMAVIRUSES; Subject Term: CERVIX uteri -- Diseases; Subject Term: PAPILLOMAVIRUS diseases; Subject Term: PRIMARY care (Medicine); Subject Term: WOMEN -- Health; Subject Term: NUCLEIC acids; Author-Supplied Keyword: detection methods; Author-Supplied Keyword: human papillomavirus; Author-Supplied Keyword: hybrid capture [non-MESH]; Author-Supplied Keyword: Vaginal smears; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107117912
T1  - Bipolar disorder: how does gender matter?
AU  - Leibenluft E
Y1  - 1999/07//
N1  - Accession Number: 107117912. Language: English. Entry Date: 20000701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 100910719. 
KW  - Bipolar Disorder -- Etiology
KW  - Sex Factors
KW  - Bipolar Disorder -- Psychosocial Factors
KW  - Postnatal Period
KW  - Women's Health
KW  - Bipolar Disorder -- Drug Therapy
KW  - Female
SP  - 13
EP  - 15
JO  - Journal of NAMI California
JF  - Journal of NAMI California
JA  - J NAMI CALIF
VL  - 10
IS  - 4
PB  - California Alliance for the Mentally Ill
AB  - Rapid cycling illness and the question of using meds while pregnant.
SN  - 1527-8786
AD  - National Institute of Mental Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kobierski, Linda A.
AU  - Wong, Allison E.
AU  - Srivastava, Smita
AU  - Borsook, David
AU  - Hyman, Steven E.
T1  - Cyclic AMP-Dependent Activation of the Proenkephalin Gene Requires Phosphorylation of CREB at Serine-133 and a Src-Related Kinase.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/07//
VL  - 73
IS  - 1
M3  - Article
SP  - 129
EP  - 138
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The transcription factor CREB [cyclic AMP response element (CRE)-binding protein] is activated by several kinase pathways on phosphorylation of serine-133. Phosphorylation of CREB at serine-133 is required for the induction of target gene expression. The proenkephalin gene is a target of cyclic AMP-dependent agonists like forskolin, and its expression is driven by the enhancer element CRE-2. It has been shown that CREB binds CRE-2 in extracts from striatum and hypothalamus. However, these studies did not show a functional requirement for CREB serine-133 phosphorylation in CRE-2 function. We demonstrate that CREB binds CRE-2 in primary astrocyte cultures and that transcriptional activation of CRE-2 requires CREB phosphorylation at serine-133. In addition, it has recently been shown that, at least in some contexts, CREB phosphorylation is not sufficient to activate target gene expression and that another intracellular signal seems to be required. Therefore, we also sought to determine if another signaling event, in addition to CREB phosphorylation, might be involved in cyclic AMP-mediated induction of the proenkephalin gene. We have found that the inhibition of src-related nonreceptor tyrosine kinases blocks forskolin-induced proenkephalin gene expression without having any effect on serine-133-phosphorylated CREB levels and that constitutively activated src kinase can activate the proenkephalin promoter. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENETIC regulation
KW  - CYCLIC adenylic acid
KW  - TRANSCRIPTION factors
KW  - cyclic amp response element-binding protein
KW  - Forskolin
KW  - Gene regulation
KW  - Proenkephalin
KW  - Src kinase
N1  - Accession Number: 5238305; Kobierski, Linda A. Wong, Allison E. Srivastava, Smita Borsook, David Hyman, Steven E. 1; Affiliation:  1: National Institute of Mental Health, Rockville, Maryland, U.S.A.; Source Info: Jul99, Vol. 73 Issue 1, p129; Subject Term: GENETIC regulation; Subject Term: CYCLIC adenylic acid; Subject Term: TRANSCRIPTION factors; Author-Supplied Keyword: cyclic amp response element-binding protein; Author-Supplied Keyword: Forskolin; Author-Supplied Keyword: Gene regulation; Author-Supplied Keyword: Proenkephalin; Author-Supplied Keyword: Src kinase; Number of Pages: 10p; Illustrations: 7 Black and White Photographs, 7 Graphs; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0730129.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107084317
T1  - Learning in Parkinson's disease: eyeblink conditioning, declarative learning, and procedural learning.
AU  - Sommer M
AU  - Grafman J
AU  - Clark K
AU  - Hallett M
Y1  - 1999/07//
N1  - Accession Number: 107084317. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Instrumentation: Beck Depression Inventory (BDI); Unified Parkinson Disease Rating Scale (UPDRS); California Verbal Learning Test (CVLT); Mattis Dementia Rating Scale; Serial Reaction Time Task (SRTT). NLM UID: 2985191R. 
KW  - Parkinson Disease
KW  - Learning
KW  - Experimental Studies
KW  - Scales
KW  - Convenience Sample
KW  - Data Analysis, Statistical
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Human
SP  - 27
EP  - 34
JO  - Journal of Neurology, Neurosurgery & Psychiatry
JF  - Journal of Neurology, Neurosurgery & Psychiatry
JA  - J NEUROL NEUROSURG PSYCHIATRY
VL  - 67
IS  - 1
PB  - BMJ Publishing Group
SN  - 0022-3050
AD  - National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland
U2  - PMID: 10369818.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107084317&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107211205
T1  - Observations. Visual illusions, science and esthetic dentistry.
AU  - Slavkin HC
Y1  - 1999/07//
N1  - Accession Number: 107211205. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Visual Perception
KW  - Esthetics, Dental
KW  - Vision -- Physiology
SP  - 1115
EP  - 1119
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 7
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, MD 20892-2290
U2  - PMID: 10422408.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107211205&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107207474
T1  - Suicide and sexual orientation: unanswered questions.
AU  - Muehrer P
Y1  - 1999/07//
N1  - Accession Number: 107207474. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 9315245. 
KW  - Suicide -- In Adolescence
KW  - Sexuality -- In Adolescence
KW  - Homosexuality
KW  - Heterosexuality
KW  - Adolescence
SP  - 64
EP  - 65
JO  - Journal of the California Alliance for the Mentally Ill
JF  - Journal of the California Alliance for the Mentally Ill
JA  - J CALIF ALLIANCE MENTALLY ILL
VL  - 10
IS  - 2
PB  - California Alliance for the Mentally Ill
AB  - When one is mentally ill and gay does suicide risk increase?
SN  - 1097-802X
AD  - National Institute of Mental Health, Rockville, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107132149
T1  - Humanity and radiation: the good, the bad, and the unusual.
AU  - Holcomb WF
Y1  - 1999/07//1999 Jul
N1  - Accession Number: 107132149. Language: English. Entry Date: 20000901. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; pictorial. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2984771R. 
KW  - Nuclear Medicine
KW  - Disasters
KW  - Radiation -- Utilization
KW  - Russia
KW  - United States
KW  - Health Promotion -- Methods
KW  - Food Handling
SP  - 520
EP  - 525
JO  - Military Medicine
JF  - Military Medicine
JA  - MILIT MED
VL  - 164
IS  - 7
CY  - Bethesda, Maryland
PB  - AMSUS
AB  - Radiation has permeated the universe since time began. People disagree widely about the merits and dangers of nuclear technology. Radiation is often associated in the minds of people with bombs, fallout, destruction, and death rather than with the many benefits of nuclear technology that are present in our daily lives. Rarely do individuals focus on the medical applications of radiation and the fact that nuclear technology saves lives. Over the years, accidents have happened in the nuclear industry; some have produced fatalities, but most proved to be a major source of concern only to the local populace. Since the discovery of naturally occurring radium and uranium and the advent of synthetic radionuclides, a number of consumer products have used radiation, some of which were beneficial and some which were of no benefit at all.
SN  - 0026-4075
AD  - National Institutes of Health, Radiation Safety Branch/Radiation Safety Training Unit, Bethesda, MD 20892-6780
U2  - PMID: 10414069.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107210215
T1  - Predicting intentions to obtain a Pap smear among African American and Latina women: testing the theory of planned behavior.
AU  - Jennings-Dozier K
Y1  - 1999/07//1999 Jul-Aug
N1  - Accession Number: 107210215. Language: English. Entry Date: 19990901. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Grant Information: Partially supported by the Institutional National Research Service Award Grant #T32 NR07036, the University of Pennsylvania William Fontaine Doctoral Fellowship Award, and the Oncology Nursing Foundation Ethnic Minority Researcher and Mentorship Grant. NLM UID: 0376404. 
KW  - Theory Validation
KW  - Cervical Smears
KW  - Ajzen-Fishbein Theory of Reasoned Action
KW  - Blacks -- United States
KW  - Hispanics -- United States
KW  - Health Behavior
KW  - Funding Source
KW  - Validation Studies
KW  - United States
KW  - Correlational Studies
KW  - Convenience Sample
KW  - Questionnaires
KW  - Coefficient Alpha
KW  - Descriptive Statistics
KW  - Path Analysis
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 198
EP  - 205
JO  - Nursing Research
JF  - Nursing Research
JA  - NURS RES
VL  - 48
IS  - 4
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - OBJECTIVE: To determine the empirical adequacy of the theory of planned behavior (TPB) to explain Pap smear use intentions in African American and Latina women. METHOD: A correlational design was used, and a convenience sample of 108 African American and 96 Latina adult women were recruited from urban community-based agencies located in a large mid-Atlantic metropolitan area. The Pap Smear Questionnaire (PSQ) was designed and used. The Demographic Assessment Survey collected demographic information (age and socioeconomic status for both groups; and level of acculturation for the Latinas). RESULTS: Direct relationships between attitude and perceived behavioral control and intention to obtain an annual Pap smear were found for African American and Latina women. The subjective norm did not significantly predict intention. Attitude (beta = .58; p < .001) provided the best explanation of intention among African American women to obtain an annual Pap smear, followed by perceived behavioral control (beta = .30; p < .001). Among Latinas, the findings reflected those of the African American sample. However, attitude (beta = .40; p < .001) and perceived behavioral control (beta = .35; p < .001) were weighted similarly. The external variables of age and income had indirect effects on intention for African American and Latina women, respectively. CONCLUSION: The study findings did not support the empirical adequacy of the TPB for either of the ethnic groups. Future studies should test a modified version of the TPB that includes measures of both social support and subjective norms. Direct measure items of subjective norm, group-specific measures of perceptions of control, and other measures of acculturation should be added to the PSQ and further tested.
SN  - 0029-6562
AD  - National Cancer Institute, Cancer Prevention Fellowship Program, 6120 Executive Blvd., Suite T41, Rockville, MD
U2  - PMID: 10414682.
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DP  - EBSCOhost
DB  - rzh
ER  - 
TY  - JOUR
ID  - 107210299
T1  - Breast cancer and African American women: moving beyond fear, fatalism, and silence.
AU  - Phillips JM
Y1  - 1999/07//1999 Jul
N1  - Accession Number: 107210299. Language: English. Entry Date: 19990901. Revision Date: 20150819. Publication Type: Journal Article; website. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033. 
KW  - Breast Neoplasms
KW  - Blacks -- United States
KW  - Women -- Psychosocial Factors
KW  - Attitude to Illness
KW  - United States
KW  - Fear
KW  - Information Resources
KW  - World Wide Web
KW  - Culture
KW  - Oncologic Nursing
KW  - Female
SP  - 1001
EP  - 1007
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 26
IS  - 6
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
SN  - 0190-535X
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, MD
U2  - PMID: 10420418.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107210299&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Somerfield, Mark R.
AU  - Stefanek, Michael F.
AU  - Smith, Thomas J.
AU  - Padberg, Jennifer J.
T1  - A systems model for adaptation to somatic distress among cancer survivors.
JO  - Psycho-Oncology
JF  - Psycho-Oncology
Y1  - 1999/07//Jul/Aug1999
VL  - 8
IS  - 4
M3  - Article
SP  - 334
EP  - 343
PB  - John Wiley & Sons, Inc.
SN  - 10579249
AB  - Applied coping research has generally failed to fulfill its goal of providing an empirical basis for clinical interventions, and research on coping with cancer is no exception. This can be attributed in large measure to the wide gap between coping theory and coping research. Theories of stress and adaptation are complex systems formulations that present conceptual and methodological challenges and thus make testing comprehensive models difficult. The present paper reviews arguments for a microanalytic strategy through which researchers can increase coverage of relevant variables from broad systems models of stress and coping by concentrating their resources on selected, high-frequency, high-stress problems. The utility of this approach for formulating problem-specific systems models is illustrated using the example of coping with somatic distress among cancer survivors. Copyright © 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psycho-Oncology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - ADAPTABILITY (Psychology)
KW  - DISTRESS (Psychology)
KW  - CANCER patients
KW  - ADJUSTMENT (Psychology)
KW  - CLINICAL trials
KW  - EMOTIONS (Psychology)
N1  - Accession Number: 11819214; Somerfield, Mark R. 1; Email Address: somerfim@asco.org Stefanek, Michael F. 2 Smith, Thomas J. 3 Padberg, Jennifer J. 1; Affiliation:  1: Health Services Research, American Society of Clinical Oncology, Alexandria, VA, USA  2: Biobehavioral Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA  3: Massey Cancer Center, Medical College of Virginia, Richmond, VA, USA; Source Info: Jul/Aug1999, Vol. 8 Issue 4, p334; Subject Term: ADAPTABILITY (Psychology); Subject Term: DISTRESS (Psychology); Subject Term: CANCER patients; Subject Term: ADJUSTMENT (Psychology); Subject Term: CLINICAL trials; Subject Term: EMOTIONS (Psychology); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107098984
T1  - Relative validity of a food frequency questionnaire among tin miners in China: 1992/93 and 1995/96 diet validation studies.
AU  - Forman MR
AU  - Zhang J
AU  - Nebeling L
AU  - Yao S
AU  - Slesinski MJ
AU  - Qiao Y
AU  - Ross S
AU  - Keith S
AU  - Maher M
AU  - Giffin C
AU  - Barrett M
AU  - Taylor PR
AU  - Graubard BI
AU  - Forman, M R
AU  - Zhang, J
AU  - Nebeling, L
AU  - Yao, S X
AU  - Slesinski, M J
AU  - Qiao, Y L
AU  - Ross, S
Y1  - 1999/07//
N1  - Accession Number: 107098984. Language: English. Entry Date: 20000401. Revision Date: 20161127. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9808463. 
KW  - Instrument Validation
KW  - Questionnaires
KW  - Diet -- China
KW  - Nutritional Assessment
KW  - China
KW  - Food Intake -- Evaluation
KW  - Seasons
KW  - Adult
KW  - Middle Age
KW  - Male
KW  - Female
KW  - Body Weights and Measures
KW  - Income
KW  - Socioeconomic Factors
KW  - Body Mass Index
KW  - Marital Status
KW  - Educational Status
KW  - Smoking
KW  - Interviews
KW  - Analysis of Variance
KW  - Descriptive Statistics
KW  - Repeated Measures
KW  - Data Analysis Software
KW  - T-Tests
KW  - Pearson's Correlation Coefficient
KW  - Confidence Intervals
KW  - Prospective Studies
KW  - Random Sample
KW  - Human
SP  - 301
EP  - 315
JO  - Public Health Nutrition
JF  - Public Health Nutrition
JA  - PUBLIC HEALTH NUTR
VL  - 2
IS  - 3
PB  - Cambridge University Press
AB  - Objective: Diet validation research was conducted to compare the respondents' reporting of dietary intake in a food frequency questionnaire (FFQ) with intake reported in food recalls. Because the population received annual salary increments that could modify food intake, diet validation studies (DVSs) were conducted during two time intervals.Design: A 99-item FFQ was administered by an interviewer twice in a 1-year interval, and responses to each FFQ item were compared with 28 days of interviewer-administered food recalls that were collected in four 1-week intervals during each season of 1992/93. The second validation study in 1995/96 had a similar design to the earlier one.Setting: A prospective cohort study of lung cancer among tin miners in China was initiated in 1992, with dietary and other risk factors updated annually.Subjects: Among a cohort of high risk tin miners for lung cancer, two different samples (n = 141 in 1992/93, and n = 113 in 1995/96) for each diet validation study were randomly selected from four mine units, that were representative of all worker units.Results: Miners reported a significantly higher average frequency of intake of foods in the food recalls than the FFQ, with few exceptions. Deattenuated Pearson correlation coefficients of the frequency of food intake between the FFQ and food recalls were in the range of -0.40 to 0.72 in both studies, with higher positive correlations for beverages and cereal staples than for animal protein sources, vegetables, fruits and legumes. The percentage of individuals with exact agreement in the extreme quartiles of intake in the food recalls and FFQ ranged from 0 to 100% in both studies.Conclusions: Among Chinese miners, the range in correlations between the food recalls and the FFQ were due to: (i) market availability of foods during the food recall weeks compared to their annual reported intake in the FFQ; (ii) cultural perception of time; and (iii) differences in how the intake of mixed dishes and their multi-ingredient foods were reported in the recalls vs. the FFQ. The range in the percentage of agreement in the same quartiles and the changes in food intake over time may have implications for the analysis of the diet-disease relationship in this cohort.
SN  - 1368-9800
AD  - Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-7326, USA
U2  - PMID: 10512565.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Peters, Jeffrey M.
AU  - Morishima, Hideki
AU  - Ward, Jerrold M.
AU  - Coakley, Christopher J.
AU  - Kimura, Shioko
AU  - Gonzalez, Frank J.
T1  - Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/07//
VL  - 50
IS  - 1
M3  - Article
SP  - 82
EP  - 89
PB  - Oxford University Press / USA
SN  - 10966080
AB  - The mechanisms underlying phenacetin-induced toxicity and carcinogenicity are not clear. In particular, it is not known whether these effects are mediated by metabolic activation of the drug. CYP1A2 is known to metabolize phenacetin in vitro. To determine the role of this enzyme in vivo, the toxicity and carcinogenicity of phenacetin was examined in Cyp1a2-null mice (that lack CYP1A2). Six- to 8-week-old wild type (+/+) or null (-/-) mice were fed either a control diet, or one containing 1.25% phenacetin, ad libitum for up to 67 weeks. Representative groups of mice were examined for phenacetin-induced toxicity and carcinogenicity after 36, 48, 58, or 67 weeks of feeding. Consistent with the known role of CYP1A2 in phenacetin metabolism, plasma levels of phenacetin were higher and acetaminophen levels lower in the (-/-) mice fed phenacetin compared to phenacetin-fed (+/+) controls. Weight gain was significantly depressed in both groups of phenacetin-fed mice after 4 weeks of feeding, and continued to be lower for the remainder of the experiment, compared to controls. Hepatomegaly and splenomegaly were more severe in (-/-) mice but present in both genotypes fed phenacetin at all time points assessed. Histological analysis of liver, kidney, spleen, and urogenital tract also revealed a differential response in the (-/-) mice fed phenacetin compared to (+/+) mice fed the same diet. Further, mortality was the most severe in the (-/-) mice fed phenacetin than in all other groups. Despite significant toxicity in (-/-) mice fed phenacetin, only one renal carcinoma was found among them. Results from this work demonstrate that, in the absence of CYP1A2, phenacetin is ore toxic than in controls. This provides evidence that metabolism of phenacetin by CYP1A2 alters toxicity in vivo, and suggests that alternate CYP1A2-independent metabolic pathways contribute to its toxicity. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cytochrome P-450
KW  - Toxicity testing
KW  - Carcinogenicity
KW  - Phenacetin
KW  - Mice as laboratory animals
KW  - carcinogenicity
KW  - carcinogenicity.
KW  - CYP1A2
KW  - cytochrome P-450 (CYP)
KW  - phenacetin
KW  - toxicity
N1  - Accession Number: 44611629; Peters, Jeffrey M. 1; Email Address: jpeters@helix.nih.gov; Morishima, Hideki 2; Ward, Jerrold M. 2; Coakley, Christopher J. 3; Kimura, Shioko 3; Gonzalez, Frank J. 1; Affiliations: 1: Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; 2: Veterinary and Tumor Pathology Section, Animal Sciences Branch, Office of Laboratory Animal Resources, Division of Basic Sciences, National Cancer Institute, Frederick, Maryland 21702-1201; 3: Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892;; Issue Info: Jul1999, Vol. 50 Issue 1, p82; Thesaurus Term: Cytochrome P-450; Thesaurus Term: Toxicity testing; Thesaurus Term: Carcinogenicity; Subject Term: Phenacetin; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: carcinogenicity.; Author-Supplied Keyword: CYP1A2; Author-Supplied Keyword: cytochrome P-450 (CYP); Author-Supplied Keyword: phenacetin; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 3 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Kirchner, Debra L.
AU  - Mercieca, Michael D.
AU  - Crowell, James A.
AU  - Levine, Barry S.
T1  - Developmental toxicity studies of 2-(difluoromethyl)-dl-ornithine (DFMO) in rats and rabbits.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/07//
VL  - 50
IS  - 1
M3  - Article
SP  - 127
EP  - 135
PB  - Oxford University Press / USA
SN  - 10966080
AB  - DFMO, an irreversible inhibitor of ornithine decarboxylase (ODC), is under development as a chemopreventive drug against cancers with pronounced proliferative phases. In support of human clinical trials, preclinical developmental toxicity studies were conducted in pregnant rats and rabbits. Rats were treated during GD 6-17, and fetuses were obtained by C-section on GD 20. Rabbits were treated during GD 7-20, and fetuses were obtained by C-section on GD 29. The dose range-finding study in rats (5/group at 0, 50, 125, 300, 800, or 1000 mg/kg/day) revealed maternal toxicity at doses ≥ 800 mg/kg/day (decreased body weights and food consumption) and developmental toxicity at doses ≥ 300 mg/kg/day (increased early resorptions and reduced fetal body weights). In the main study, rats (25/group) received 0, 30, 80 or 200 mg/kg/day. Developmental toxicity in the absence of maternal toxicity was observed at 200 mg/kg/day as significantly decreased fetal weights and increased incidence of litters with skeletal variations of 14th rudimentary rib, 14th full rib, and/or 27th presacral vertebrae. There were no treatment-related fetal skeletal malformations or external or visceral anomalies at any dose level. The dose range-finding study in rabbits (5/group at 0, 30, 60, 120, 240, or 500 mg/kg/day) revealed developmental toxicity at doses ≥ 60 mg/kg/day (increased resorptions and reduced fetal body weights) in the absence of maternal toxicity. In the main study, rabbits (20/group) received 0, 15, 45, or 135 mg/kg/day. Developmental toxicity in the absence of maternal toxicity was observed at 135 mg/kg/day as nonsignificantly increased early resorptions, decreased implantation sites, decreased viable fetuses, and reduced fetal weights. There were no external, visceral, or skeletal anomalies at any dose level. Thus, in the main developmental toxicity studies, DFMO produced developmental but not maternal toxicity at 200 and 125 mg/kg/day in rats and rabbits, respectively. Accordingly, in rats, the maternal no-observable-effect level (NOEL) was 200 mg/kg/day and the fetal NOEL was 80 mg/kg/day; while in rabbits the maternal NOEL was 135 mg/kg/day and the fetal NOEL was 45 mg/kg/day. These fetal NOELs are several-fold higher than the dose level currently used in Phase II and III clinical trials ( 13 mg/kg). [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxicity testing
KW  - Ornithine decarboxylase
KW  - Drugs -- Toxicology
KW  - Chemoprevention
KW  - Teratology
KW  - Rats as laboratory animals
KW  - Rabbits as laboratory animals
KW  - cancer chemopreventive
KW  - developmental toxicity
KW  - Difluoromethylornithine
KW  - embryotoxicity
KW  - fetotoxicity
KW  - maternal toxicity
KW  - ornithine decarboxylase
KW  - polyamine
KW  - rabbit.
KW  - rat
KW  - skeletal
KW  - teratology
N1  - Accession Number: 44611634; Kirchner, Debra L. 1; Mercieca, Michael D. 2; Crowell, James A. 3; Levine, Barry S. 1; Email Address: bslevine@uic.edu; Affiliations: 1: Toxicology Research Laboratory, University of Illinois, Chicago, Chicago, Illinois 60612; 2: Pathology Associates International, Frederick, Maryland 21701; 3: Chemoprevention Branch, National Cancer Institute, Rockville, Maryland 20892; Issue Info: Jul1999, Vol. 50 Issue 1, p127; Thesaurus Term: Toxicity testing; Subject Term: Ornithine decarboxylase; Subject Term: Drugs -- Toxicology; Subject Term: Chemoprevention; Subject Term: Teratology; Subject Term: Rats as laboratory animals; Subject Term: Rabbits as laboratory animals; Author-Supplied Keyword: cancer chemopreventive; Author-Supplied Keyword: developmental toxicity; Author-Supplied Keyword: Difluoromethylornithine; Author-Supplied Keyword: embryotoxicity; Author-Supplied Keyword: fetotoxicity; Author-Supplied Keyword: maternal toxicity; Author-Supplied Keyword: ornithine decarboxylase; Author-Supplied Keyword: polyamine; Author-Supplied Keyword: rabbit.; Author-Supplied Keyword: rat; Author-Supplied Keyword: skeletal; Author-Supplied Keyword: teratology; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2006-00310-001
AN  - 2006-00310-001
AU  - Bussey, Timothy J.
AU  - Murray, Elisabeth A.
T1  - 'Perceptual-mnemonic functions of perirhinal cortex': Reply.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1999/07//
VL  - 3
IS  - 7
SP  - 249
EP  - 250
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Bussey, Timothy J., Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B80, Bethesda, MD, US, 20892-4415
N1  - Accession Number: 2006-00310-001. PMID: 10377537 Partial author list: First Author & Affiliation: Bussey, Timothy J.; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060417. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Cerebral Cortex; Semantic Memory; Temporal Lobe. Minor Descriptor: Dementia. Classification: Neuropsychology & Neurology (2520). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jul, 1999. 
AB  - Replies to the comments made by J. S. Simons, K. S. Graham, K.S. and J. R. Hodges (see record [rid]2006-00310-005[/rid]) on the original article 'Perceptual-mnemonic functions of perirhinal cortex' (1999). We believe that the finding reported by the authors, that the severity of semantic dementia (SD) is related to the extent of damage to the anterolateral temporal cortex, is entirely consistent with our model, regardless of whether the damage includes the perirhinal cortex (PRh). This is because our model assumes that the neural circuitry coding a visual representation of an object is widely distributed throughout inferior temporal (IT) cortex. Furthermore, based on anatomical considerations, damage to caudal cortical fields might be expected to have two effects: removing parts of representations stored in that cortical field, and 'disconnecting' downstream fields from their normal pattern of sensory input. If this analysis is correct, then damage to more lateral or caudal portions of IT might be expected to have a somewhat greater effect on semantic memory than would damage to rostral regions alone. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - semantic dementia
KW  - perirhinal cortex
KW  - temporal cortex
KW  - brain lesions
KW  - semantic memory
KW  - 1999
KW  - Cerebral Cortex
KW  - Semantic Memory
KW  - Temporal Lobe
KW  - Dementia
KW  - 1999
DO  - 10.1016/S1364-6613(99)01335-2
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00310-001&site=ehost-live&scope=site
UR  - eam@ln.nimh.nih.gov
UR  - bussey@ln.nimh.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-00310-007
AN  - 2006-00310-007
AU  - Wise, Steven P.
T1  - Review of The prefrontal cortex: Executive and cognitive functions.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1999/07//
VL  - 3
IS  - 7
SP  - 280
EP  - 281
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Wise, Steven P., National Institute of Mental Health, Poolesville, MD, US, 20837
N1  - Accession Number: 2006-00310-007. Partial author list: First Author & Affiliation: Wise, Steven P.; National Institute of Mental Health, Poolesville, MD, US. Release Date: 20060417. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Ability; Cognitive Processes; Memory; Prefrontal Cortex. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). Reviewed Item: Roberts, A. C. (Ed); Robbins, T. W. (Ed); Weiskrantz, L. (Ed). The prefrontal cortex: Executive and cognitive functions=Oxford University Press, 1998. £22.99 (viii + 248 pages); 1998. References Available: Y. Page Count: 2. Issue Publication Date: Jul, 1999. 
AB  - Reviews the book, The prefrontal cortex: Executive and cognitive functions edited by A. C. Roberts, T. W. Robbins, and L. Weiskrantz (Eds.) (see record [rid]1999-02185-000[/rid]). This book attempts to answer the question: What are the functions of the primate prefrontal cortex? This volume's most noteworthy contributions focus on memory, strategies and response selection, the role of dopamine in development and the potential contribution of prefrontal dysfunction to schizophrenia. One of the chapters explain the somatic marker hypothesis, which holds that a central representation of body state (gut feeling) plays an essential role in decisions concerning oneself and others. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - cognitive functions
KW  - prefrontal cortex
KW  - executive functions
KW  - memory
KW  - 1999
KW  - Cognitive Ability
KW  - Cognitive Processes
KW  - Memory
KW  - Prefrontal Cortex
KW  - 1999
U2  - Roberts, A. C. (Ed); Robbins, T. W. (Ed); Weiskrantz, L. (Ed). (1998); The prefrontal cortex: Executive and cognitive functions; Oxford University Press, 1998. £22.99 (viii + 248 pages); 0198524412 (Paperback).
DO  - 10.1016/S1364-6613(99)01348-0
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00310-007&site=ehost-live&scope=site
UR  - spw@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2006-00987-002
AN  - 2006-00987-002
AU  - Palkovits, M.
AU  - Baffi, J. S.
AU  - Pacak, K.
T1  - The Role of Ascending Neuronal Pathways in Stress-Induced Release of Noradrenaline in the Hypothalamic Paraventricular Nucleus of Rats.
JF  - Journal of Neuroendocrinology
JO  - Journal of Neuroendocrinology
JA  - J Neuroendocrinol
Y1  - 1999/07//
VL  - 11
IS  - 7
SP  - 529
EP  - 539
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-8194
SN  - 1365-2826
AD  - Palkovits, M., Laboratory of Genetics, NIHM, NIH, Building 36, Room 3D06, Bethesda, MD, US, 20892
N1  - Accession Number: 2006-00987-002. PMID: 10444310 Partial author list: First Author & Affiliation: Palkovits, M.; Laboratory of Neuromorphology, Semmelweis University Medical School, Budapest, Hungary. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Afferent Pathways; Hypothalamus; Norepinephrine; Pain Perception; Stress. Minor Descriptor: Immunoreactivity; Neuroendocrinology; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul, 1999. 
AB  - Central catecholaminergic pathways carrying pain-related signals to the hypothalamic paraventricular nucleus (PVN) were investigated in laboratory rats. Four per cent formalin injected subcutaneously was employed as a stressful stimulus. Neuronal activity in brainstem catecholaminergic and paraventricular neurones was assessed by Fos immunohistochemistry. Stress-induced noradrenaline (NE) release from nerve terminals in the PVN was measured in extracellular fluid by in-vivo microdialysis. Within 30 min, formalin elicited a four- to sixfold increase in plasma ACTH and corticosterone concentrations and intense Fos-like activity was seen in the superficial zones of the lumbar spinal cord ipsilateral to the side of the formalin injection. In brainstem catecholaminergic neurones, the PVN, and midline thalamic nuclei, formalin-induced Fos-immunopositivity was equally present in the ipsi- and contralateral sides of the injection. An immediate elevation (4-5 times higher than baseline levels) of NE levels was measured in both the right and left PVN after a formalin injection into the right paw. Unilateral surgical transections at the medulla-spinal cord junction failed to affect formalin-induced elevations in NE levels in the PVN independently of the side of the formalin injection or the knife cut. Thus, this observation clearly shows that fibres carrying pain-evoked signals ascend bilaterally from the spinal cord to the brainstem and forebrain. Hemisections of the medulla oblongata between the level of A1-A2 NE cell groups and the locus coeruleus reduced but did not eliminate formalin-induced NE release from the PVN ipsilateral to the knife cut. This effect was independent of the side of the formalin injection. In the contralateral PVN, high and similar NE levels were measured in response to a formalin injection into the right or the left leg. The present study indicates that formalin-induced pain signals are carried by sensory fibres to the ipsilateral spinal cord. From there, axons of different dorsal horn neurones reach noradrenergic cells on both sides of the medulla oblongata. The majority of noradrenergic fibers ascend on the same side and innervate the ipsilateral PVN. Since formalin administration resulted in a moderate elevation of NE levels in the PVN on the operated side, the role of other ascending noradrenergic (from the locus coeruleus) or noncatecholaminergic fibres that could modulate NE release from the PVN should be considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuronal pathways
KW  - stress
KW  - noradrenaline release
KW  - hypothalamus
KW  - paraventricular nucleus
KW  - rats
KW  - neuroendocrinology
KW  - pain signals
KW  - 1999
KW  - Afferent Pathways
KW  - Hypothalamus
KW  - Norepinephrine
KW  - Pain Perception
KW  - Stress
KW  - Immunoreactivity
KW  - Neuroendocrinology
KW  - Rats
KW  - 1999
U1  - Sponsor: Hungarian National Fund. Grant: T017137. Recipients: No recipient indicated
DO  - 10.1046/j.1365-2826.1999.00365.x
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UR  - 
UR  - ORCID: 0000-0003-0578-0387
UR  - palkovit@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43839-020
AN  - 2015-43839-020
AU  - Ghiani, Cristina A.
AU  - Yuan, Xiaoqing
AU  - Eisen, Alex M.
AU  - Knutson, Peter L.
AU  - DePinho, Ronald A.
AU  - McBain, Chris J.
AU  - Gallo, Vittorio
T1  - Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27Kip1 and p21CIP1 in glial progenitor cells.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/07//
VL  - 19
IS  - 13
SP  - 5380
EP  - 5392
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Gallo, Vittorio, Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A-78, 49 Convent Drive, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-43839-020. PMID: 10377348 Partial author list: First Author & Affiliation: Ghiani, Cristina A.; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ghiani, Cristina A. Major Descriptor: Electrolytes; Depolarization; Ion Channel; Cell Proliferation; Progenitor Cells. Minor Descriptor: Mice. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 13. Issue Publication Date: Jul, 1999. Publication History: Accepted Date: Apr 14, 1999; First Submitted Date: Feb 17, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Neural cell development is regulated by membrane ion channel activity. We have previously demonstrated that cell membrane depolarization with veratridine or blockage of K+ channels with tetraethylammonium (TEA) inhibit oligodendrocyte progenitor (OP) proliferation and differentiation (Knutson et al., 1997); however the molecular events involved are largely unknown. Here we show that forskolin (FSK) and its derivative dideoxyforskolin (DFSK) block K+ channels in OPs and inhibit cell proliferation. The antiproliferative effects of TEA, FSK, DFSK, and veratridine were attributable to OP cell cycle arrest in G1 phase. In fact, (1) cyclin D accumulation in synchronized OP cells was not affected by K+ channel blockers or veratridine; (2) these agents prevented OP cell proliferation only if present during G1 phase; and (3) G1 blockers, such as rapamycin and deferoxamine, mimicked the anti-proliferative effects of K+ channel blockers. DFSK also prevented OP differentiation, whereas FSK had no effect. Blockage of K+ channels and membrane depolarization also caused accumulation of the cyclin-dependent kinase inhibitors p27Kip1 and p21CIP1 in OP cells. The antiproliferative effects of K1 channel blockers and veratridine were still present in OP cells isolated from INK4a-/- mice, lacking the cyclindependent kinase inhibitors p16INK4a and p19ARF. Our results demonstrate that blockage of K+ channels and cell depolarization induce G1 arrest in the OP cell cycle through a mechanism that may involve p27Kip1 and p21CIP1 and further support the conclusion that OP cell cycle arrest and differentiation are two uncoupled events. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - oligodendrocyte development
KW  - cell cycle
KW  - ion channels
KW  - G1 arrest
KW  - cell proliferation
KW  - cyclin D
KW  - 1999
KW  - Electrolytes
KW  - Depolarization
KW  - Ion Channel
KW  - Cell Proliferation
KW  - Progenitor Cells
KW  - Mice
KW  - 1999
U1  - Sponsor: National Research Council of Italy, Italy. Other Details: Fellowship. Recipients: Ghiani, Cristina A.
U1  - Sponsor: National Institute of Child Health and Human Development, US. Other Details: Pre-Intramural Research Training Award fellowship. Recipients: Eisen, Alex M.; Knutson, Peter L.
U1  - Sponsor: National Institutes of Health, US. Recipients: DePinho, Ronald A.
U1  - Sponsor: Sponsor name not included. Other Details: Irma T. Hirschl Award. Recipients: DePinho, Ronald A.
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43839-027
AN  - 2015-43839-027
AU  - Rubio, Maria E.
AU  - Wenthold, Robert J.
T1  - Differential distribution of intracellular glutamate receptors in dendrites.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/07//
VL  - 19
IS  - 13
SP  - 5549
EP  - 5562
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Rubio, Maria E., National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 36, Room 5D08, 36 Convent Drive, Bethesda, MD, US, 20892-4162
N1  - Accession Number: 2015-43839-027. PMID: 10377362 Partial author list: First Author & Affiliation: Rubio, Maria E.; Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dendrites; Synapses; Pyramidal Neurons; Endoplasmic Reticulum. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: Jul, 1999. Publication History: Accepted Date: Apr 8, 1999; Revised Date: Mar 31, 1999; First Submitted Date: Feb 12, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Glutamate receptors are synthesized in the cell body and transported in intracellular compartments to the target synapse. The objective of the present study was to analyze the intracellular pool of glutamate receptors and determine whether the intracellular pool was related to the synaptic distribution of the receptors. As a model system, we chose the fusiform cell of the dorsal cochlear nucleus for which we have previously demonstrated that receptors are selectively targeted to synapses on apical and basal dendrites. A combination of retrograde tracing and postembedding immunogold labeling was used to quantify intracellular receptors in segments of apical and basal dendrites. Immunolabeling for GluR4 and mGluR1α is present at synapses on basal dendrites but not on apical dendrites, whereas immunolabeling for GluR2/3 is present at both populations of synapses. In the analysis of intracellular pools, we find that GluR2/3 is equally distributed in apical and basal dendrites, whereas GluR4 and mGluR1α are more concentrated in basal dendrites than in apical dendrites. These findings indicate that the distribution of intracellular receptors is related to that of synaptic receptors and suggest that a mechanism exists in neurons to target proteins to dendritic domains soon after synthesis. We found no evidence for the existence of a pool of intracellular receptors, which could represent a receptor reserve, near the postsynaptic density. Receptors were often found in clusters associated with tubulovesicular membranes of the endoplasmic reticulum, identified with immunoglobulin binding protein (BIP) or calnexin, suggesting that this organelle is involved in receptor transport in dendrites. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - glutamate receptor
KW  - immunocytochemistry
KW  - dendrite
KW  - postembedding
KW  - targeting
KW  - cochlear nucleus
KW  - 1999
KW  - Dendrites
KW  - Synapses
KW  - Pyramidal Neurons
KW  - Endoplasmic Reticulum
KW  - 1999
U1  - Sponsor: National Institute on Deafness and Other Communication Disorders, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43860-033
AN  - 2015-43860-033
AU  - Ohshima, Toshio
AU  - Gilmore, Edward C.
AU  - Longenecker, Glenn
AU  - Jacobowitz, David M.
AU  - Brady, Roscoe O.
AU  - Herrup, Karl
AU  - Kulkarni, Ashok B.
T1  - Migration defects of cdk5−/− neurons in the developing cerebellum is cell autonomous.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/07//
VL  - 19
IS  - 14
SP  - 6017
EP  - 6026
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ohshima, Toshio, Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2–1 Hirosawa, Wako, Saitama, Japan, 351 0198
N1  - Accession Number: 2015-43860-033. PMID: 10407039 Partial author list: First Author & Affiliation: Ohshima, Toshio; Functional Genomics Unit, Gene Targeting Facility, National Institute of Dental and Craniofacial Research, MD, US. Release Date: 20160822. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Herrup, Karl. Major Descriptor: Cerebellum; Cerebral Cortex; Kinases; Purkinje Cells; Migration of Nerve Cells. Minor Descriptor: Mice; Granule Cells. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1999. Publication History: Accepted Date: May 5, 1999; Revised Date: May 3, 1999; First Submitted Date: Dec 23, 1998. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Cyclin-dependent kinase 5 (Cdk5) is a member of the family of cell cycle-related kinases. Previous neuropathological analysis of cdk5-/- mice showed significant changes in CNS development in regions from cerebral cortex to brainstem. Among the defects in these animals, a disruption of the normal pattern of cell migrations in cerebellum was particularly apparent, including a pronounced abnormality in the location of cerebellar Purkinje cells. Complete analysis of this brain region is hampered in the mutant because most of cerebellar morphogenesis occurs after birth and the cdk5-/- mice die in the perinatal period. To overcome this disadvantage, we have generated chimeric mice by injection of cdk5-/- embryonic stem cells into host blastocysts. Analysis of the cerebellum from the resulting cdk5-/- 7 cdk5+/+ chimeric mice shows that the abnormal location of the mutant Purkinje cells is a cell-autonomous defect. In addition, significant numbers of granule cells remain located in the molecular layer, suggesting a failure to complete migration from the external to the internal granule cell layer. In contrast to the Purkinje and granule cell populations, all three of the deep cerebellar nuclear cell groupings form correctly and are composed of cells of both mutant and wild-type genotypes. Despite similarities of the cdk5-/- phenotype to that reported in reeler and mdab-1-/- (scrambler/ yotari) mutant brains, reelin and disabled-1 mRNA were found to be normal in cdk5-/- brain. Together, the data further support the hypothesis that Cdk5 activity is required for specific components of neuronal migration that are differentially required by different neuronal cell types and by even a single neuronal cell type at different developmental stages. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neuronal migration
KW  - cdk5
KW  - cerebellar development
KW  - Purkinje cell
KW  - granule cell
KW  - cell autonomous
KW  - 1999
KW  - Cerebellum
KW  - Cerebral Cortex
KW  - Kinases
KW  - Purkinje Cells
KW  - Migration of Nerve Cells
KW  - Mice
KW  - Granule Cells
KW  - 1999
U1  - Sponsor: National Institutes of Health, US. Grant: NS20591. Recipients: Herrup, Karl
U1  - Sponsor: National Institute of Dental and Craniofacial Research, US. Recipients: Kulkarni, Ashok B.
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, Division of Intramural Research, US. Recipients: Kulkarni, Ashok B.
U1  - Sponsor: Japan Society for the Promotion of Science, Japan. Other Details: Research Fellowship for Japanese Biomedical and Behavioral Researchers at National Institutes of Health. Recipients: Ohshima, Toshio
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - ABST
AU  - Hee-Yong Kim
AU  - Akbar, Mohammed
T1  - NEURONAL APOPTOSIS IS PREVENTED BY DOCOSAHEXAENOIC ACID (22:6N-3).
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/07/02/Jul99 Supplement
VL  - 73
M3  - Abstract
SP  - S10
EP  - S10
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the study "Neuronal Apoptosis Is Prevented by Docosahexaenoic Acid (22:6N-3)." It will be presented at a joint meeting of the International Society for Neurochemistry and the European Society for Neurochemistry, that will be held during August 8-14, 1999, in Berlin, Germany. The results of the study show that the presence of 22:6N-3 in neuronal cells prevents apoptotic cell death and increases the accumulation of phosphatidylserine in cell membranes.
KW  - APOPTOSIS
KW  - NEURONS
KW  - DOCOSAHEXAENOIC acid
KW  - CELL death
KW  - PHOSPHATIDYLSERINES
KW  - CELL membranes
KW  - ABSTRACTS
N1  - Accession Number: 23426525; Hee-Yong Kim 1 Akbar, Mohammed 1; Affiliation:  1: Section of Mass Spectrometry, LMBB, NIAAA, National Institutes of Health, Rockville, MD 20852, USA.; Source Info: Jul99 Supplement, Vol. 73, pS10; Subject Term: APOPTOSIS; Subject Term: NEURONS; Subject Term: DOCOSAHEXAENOIC acid; Subject Term: CELL death; Subject Term: PHOSPHATIDYLSERINES; Subject Term: CELL membranes; Subject Term: ABSTRACTS; Number of Pages: 1/4p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Igbavboa, U.
AU  - Hamilton, J.
AU  - Kim, H.-Y.
AU  - Avdulov, N. A.
AU  - Chochina, S. V.
AU  - Wood, W. G.
T1  - PHOSPHOLIPID MOLECULAR SPECIES IN SYNAPTIC PLASMA MEMBRANES OF APOE-DEFICIENT AND C57BL/6J MICE.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/07/02/Jul99 Supplement
VL  - 73
M3  - Abstract
SP  - S21
EP  - S21
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the study "Phospholipid Molecular Species in Synaptic Plasma Membranes of ApoE-Deficient and C57BL/6J Mice." The study will be presented at a joint meeting of the International Society for Neurochemistry and the European Society for Neurochemistry which will be organized in Berlin, Germany, from August 8-14, 1999. The study found an association between cholesterol asymmetry and phospholipid molecular species distribution.
KW  - PHOSPHOLIPIDS
KW  - CELL membranes
KW  - CHOLESTEROL
KW  - APOLIPOPROTEIN E
KW  - NEURAL transmission
KW  - ABSTRACTS
N1  - Accession Number: 23426566; Igbavboa, U. 1 Hamilton, J. 2 Kim, H.-Y. 2 Avdulov, N. A. 1 Chochina, S. V. 1 Wood, W. G. 1; Affiliation:  1: VA Med. Ctr., GRECC, Univ. Minn. Dept. Pharmacology, Minneapolis, MN.  2: National Institutes of Health, NIAAA, Bethesda, MD.; Source Info: Jul99 Supplement, Vol. 73, pS21; Subject Term: PHOSPHOLIPIDS; Subject Term: CELL membranes; Subject Term: CHOLESTEROL; Subject Term: APOLIPOPROTEIN E; Subject Term: NEURAL transmission; Subject Term: ABSTRACTS; Number of Pages: 1/4p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - ABST
AU  - Jakubik, J.
T1  - ASPECTS OF THE REGULATION AND MOLECULAR ASSEMBLY OF MUSCARINIC ACETYLCHOLINE RECEPTORS.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/07/02/Jul99 Supplement
VL  - 73
M3  - Abstract
SP  - S160
EP  - S160
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The article presents an abstract of the study "Aspects of the Regulation and Molecular Assembly of Muscarinic Acetylcholine Receptors." In the study, interactions between five allosteric modulators and twelve muscarinic agonists on the M1--M4 muscarinic receptor subtypes were examined. It was found that each modulator enhanced the affinity of at least one subtype of muscarinic receptors for at least one agonist.
KW  - CHOLINERGIC receptors
KW  - MUSCARINIC receptors
KW  - ALLOSTERIC regulation
KW  - CHOLINE
KW  - NEUROCHEMISTRY
KW  - ABSTRACTS
N1  - Accession Number: 23427111; Jakubik, J. 1,2; Affiliation:  1: National Institutes of Health, Bethesda, MD 20892, U.S.A.  2: Institute of Physiology, Academy of Science, 14220 Prague, Czech Republic.; Source Info: Jul99 Supplement, Vol. 73, pS160; Subject Term: CHOLINERGIC receptors; Subject Term: MUSCARINIC receptors; Subject Term: ALLOSTERIC regulation; Subject Term: CHOLINE; Subject Term: NEUROCHEMISTRY; Subject Term: ABSTRACTS; Number of Pages: 1/4p; Document Type: Abstract
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Rehermann, B.
T1  - Cellular immune response to the hepatitis C virus.
JO  - Journal of Viral Hepatitis
JF  - Journal of Viral Hepatitis
Y1  - 1999/07/02/Jul1999 Supplement
VL  - 6
M3  - Article
SP  - 31
EP  - 35
PB  - Wiley-Blackwell
SN  - 13520504
AB  - Hepatitis C virus (HCV) infection is most often clinically inapparent and rarely associated with symptoms of acute hepatitis. Most patients, however, fail to resolve the acute infection and proceed to develop chronic hepatitis with the risk of liver cirrhosis and hepatocellular carcinoma later in life. Since the kinetics of the earliest events of virus-host interaction are likely to determine the outcome of infection, research has focused on the characterization of the strength and kinetics of the antiviral immune response in different stages of disease. The identification of the immunological correlates of viral clearance is pivotal for the development of vaccines and efficient therapies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Viral Hepatitis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - IMMUNE response
KW  - HEPATITIS C
KW  - PATIENTS
KW  - HEPATITIS C virus
KW  - ANTIVIRAL agents
KW  - HEPATITIS -- Vaccination
KW  - CLINICAL trials
N1  - Accession Number: 64379051; Rehermann, B. 1; Affiliation:  1: Liver Diseases Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Jul1999 Supplement, Vol. 6, p31; Subject Term: IMMUNE response; Subject Term: HEPATITIS C; Subject Term: PATIENTS; Subject Term: HEPATITIS C virus; Subject Term: ANTIVIRAL agents; Subject Term: HEPATITIS -- Vaccination; Subject Term: CLINICAL trials; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
L3  - 10.1046/j.1365-2893.1999.00008.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Katzman, Gregory L.
AU  - Dagher, Azar P.
AU  - Patronas, Nicholas J.
AU  - Katzman, G L
AU  - Dagher, A P
AU  - Patronas, N J
T1  - Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/07/07/
VL  - 282
IS  - 1
M3  - journal article
SP  - 36
EP  - 39
SN  - 00987484
AB  - <bold>Context: </bold>Previous reports have discussed incidental disease found on brain magnetic resonance imaging (MRI) scans that had been requested for an unrelated clinical concern or symptom, resulting in a selection bias for disease. However, the prevalence of unexpected abnormalities has not been studied in a healthy population.<bold>Objective: </bold>To evaluate the prevalence of incidental findings on brain MRI scans obtained for a healthy, asymptomatic population without selection bias.<bold>Design, Setting, and Participants: </bold>Retrospective analysis of brain MRI scans obtained between May 17, 1996, and July 25, 1997, from 1000 volunteers who participated as control subjects for various research protocols at the National Institutes of Health. All participants (age range, 3-83 years; 54.6% male) were determined to be healthy and asymptomatic by physician examination and participant history.<bold>Main Outcome Measure: </bold>Prevalence of abnormalities on brain MRI by category of finding (no referral necessary, routine referral, urgent referral [within 1 week of study], and immediate referral [within 1 to several days of study]).<bold>Results: </bold>Eighty-two percent of the MRI results were normal. Of the 18% demonstrating incidental abnormal findings, 15.1% required no referral; 1.8%, routine referral; 1.1%, urgent referral; and 0%, immediate referral. In subjects grouped for urgent referral, 2 confirmed primary brain tumors (and a possible but unconfirmed third) were found, demonstrating a prevalence of at least 0.2%.<bold>Conclusion: </bold>Asymptomatic subjects present with a variety of abnormalities, providing valuable information on disease prevalence in a presumed healthy population. A small percentage of these findings require urgent medical attention and/or additional studies. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MAGNETIC resonance imaging
KW  - BRAIN -- Magnetic resonance imaging
KW  - DIAGNOSTIC imaging
KW  - IMAGING systems in medicine
N1  - Accession Number: 2004605; Katzman, Gregory L. Dagher, Azar P. Patronas, Nicholas J. Katzman, G L 1 Dagher, A P Patronas, N J; Affiliation:  1: Diagnostic Radiology Department, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 7/7/99, Vol. 282 Issue 1, p36; Subject Term: MAGNETIC resonance imaging; Subject Term: BRAIN -- Magnetic resonance imaging; Subject Term: DIAGNOSTIC imaging; Subject Term: IMAGING systems in medicine; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 4p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Prioleau, Marie-Noëlle
AU  - Nony, Pascale
AU  - Simpson, Melanie
AU  - Felsenfeld, Gary
T1  - An insulator element and condensed chromatin region separate the chicken ß-globin locus from an independently regulated erythroid-specific folate receptor gene.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/07/15/
VL  - 18
IS  - 14
M3  - Article
SP  - 4035
EP  - 4048
SN  - 02614189
AB  - We have identified a folate receptor gene upstream of the chicken β-globin locus and separated from it by a 16 kbp region of silent chromatin. We find that this receptor is expressed only at a stage of erythroid differentiation ((FU-E) preceding the activation of β-globin genes, consistent with the role of folate receptors in proliferation. This discovery raises the question of how these two loci are regulated during erythropoiesis. Our data suggest that the folate receptor gene and the β-globin locus are regulated independently. We show that a 3.3 kbp DNA region upstream of the folate receptor gene is sufficient to induce strong expression of a transgene in (FU-E stage cells. We also find that the region between the β-globin locus and the folate receptor gene is fully methylated and condensed at this stage of differentiation. Its 3′ boundary coincides with the 5′- β-globin boundary element might be important for the proper regulation of two adjacent domains activated at two different stages during differentiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE expression
KW  - CHROMATIN
KW  - GENES
KW  - ERYTHROPOIESIS
KW  - GLOBIN
KW  - CHICKENS
KW  - β-globin locus
KW  - boundary
KW  - condensed chromatin
KW  - domain
KW  - methylation
N1  - Accession Number: 13004188; Prioleau, Marie-Noëlle 1 Nony, Pascale 2 Simpson, Melanie 3 Felsenfeld, Gary 3; Email Address: gary.felsenfeld@nih.gov; Affiliation:  1: Laboratoire de Génétique Moléculaire, CNRS URA 1302, 46 rue d'Ulm, 75230 Paris Cedex 05, France  2: Laboratoire de Thérapie Génique, B^acirc;timent Jean Monnet-Hôtel Dieu 30, boulevard Jean Monnet, 44035 Nantes Cedex 1, France  3: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0540, USA; Source Info: 7/15/99, Vol. 18 Issue 14, p4035; Subject Term: GENE expression; Subject Term: CHROMATIN; Subject Term: GENES; Subject Term: ERYTHROPOIESIS; Subject Term: GLOBIN; Subject Term: CHICKENS; Author-Supplied Keyword: β-globin locus; Author-Supplied Keyword: boundary; Author-Supplied Keyword: condensed chromatin; Author-Supplied Keyword: domain; Author-Supplied Keyword: methylation; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; Number of Pages: 14p; Document Type: Article
L3  - 10.1093/emboj/18.14.4035
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Young, Neal S.
AU  - Young, N S
T1  - Acquired aplastic anemia.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/07/21/
VL  - 282
IS  - 3
M3  - journal article
SP  - 271
EP  - 278
SN  - 00987484
AB  - Discusses acquired aplastic anemia.  Case study of a man with profound hypocellularity and virtual absence of hematopoietic cells in his bone marrow.  His condition two and half years after the onset of the bone marrow failure; History of aplastic anemia; Pathophysiology; Etiologies; Definitive therapies; Supportive care.
KW  - APLASTIC anemia
KW  - BLOOD diseases
KW  - BONE marrow diseases
KW  - ERYTHROCYTE disorders
KW  - APLASTIC anemia -- Treatment
KW  - DIAGNOSIS
KW  - BLOOD transfusion
KW  - HEPATITIS
KW  - IMMUNOSUPPRESSION
N1  - Accession Number: 2051329; Young, Neal S. Young, N S 1; Affiliation:  1: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA; Source Info: 7/21/99, Vol. 282 Issue 3, p271; Subject Term: APLASTIC anemia; Subject Term: BLOOD diseases; Subject Term: BONE marrow diseases; Subject Term: ERYTHROCYTE disorders; Subject Term: APLASTIC anemia -- Treatment; Subject Term: DIAGNOSIS; Subject Term: BLOOD transfusion; Subject Term: HEPATITIS; Subject Term: IMMUNOSUPPRESSION; Number of Pages: 8p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 1 Graph; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107032014
T1  - Maternal size at birth and the development of hypertension during pregnancy: a test of the Barker hypothesis.
AU  - Klebanoff MA
AU  - Secher NJ
AU  - Mednick BR
AU  - Schulsinger C
Y1  - 1999/07/26/
N1  - Accession Number: 107032014. Language: English. Entry Date: 20010622. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by contract NO1-HD-7-2902 from the National Institutes of Health, Bethesda, MD. NLM UID: 0372440. 
KW  - Hypertension -- Etiology -- In Pregnancy
KW  - Pregnancy Complications, Cardiovascular -- Etiology
KW  - Birth Weight
KW  - Female
KW  - Pregnancy
KW  - Gestational Age
KW  - Denmark
KW  - Prospective Studies
KW  - Confidence Intervals
KW  - Odds Ratio
KW  - Interviews
KW  - Chi Square Test
KW  - T-Tests
KW  - Education, Continuing (Credit)
KW  - Funding Source
KW  - Human
SP  - 1607
EP  - 1631
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
JA  - ARCH INTERN MED
VL  - 159
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0003-9926
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Bldg, Room 7B03, Bethesda, MD 20892-7510
U2  - PMID: 10421284.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Mills, James L.
AU  - DerSimonian, Rebecca
AU  - Raymond, Elizabeth
AU  - Morrow, Jason D.
AU  - Roberts II, L. Jackson
AU  - Clemens, John D.
AU  - Hauth, John C.
AU  - Catalano, Patrick
AU  - Sibai, Baha
AU  - Curet, L.B.
AU  - Levine, Richard J.
AU  - Mills, J L
AU  - DerSimonian, R
AU  - Raymond, E
AU  - Morrow, J D
AU  - Roberts, L J 2nd
AU  - Clemens, J D
AU  - Hauth, J C
AU  - Catalano, P
AU  - Sibai, B
T1  - Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/07/28/
VL  - 282
IS  - 4
M3  - journal article
SP  - 356
EP  - 362
SN  - 00987484
AB  - <bold>Context: </bold>An imbalance in vasodilating (prostacyclin [PGI2]) and vasoconstricting (thromboxane A2 [TxA2]) eicosanoids may be important in preeclampsia, but prospective data from large studies needed to resolve this issue are lacking. Because most trials using aspirin to reduce TxA2 production have failed to prevent preeclampsia, it is critical to determine whether eicosanoid changes occur before the onset of clinical disease or are secondary to clinical manifestations of preeclampsia.<bold>Objective: </bold>To determine whether PGI2 or TxA2 changes occur before onset of clinical signs of preeclampsia.<bold>Design, Setting, and Participants: </bold>Multicenter prospective study from 1992 to 1995 of subjects from the placebo arm of the Calcium for Preeclampsia Prevention Trial. Women who developed preeclampsia (n = 134) were compared with matched normotensive control women (n = 139).<bold>Main Outcome Measures: </bold>Excretion of urinary metabolites of PGI2 (PGI-M) and TxA2 (Tx-M) as measured from timed urine collections obtained prospectively before 22 weeks', between 26 and 29 weeks', and at 36 weeks' gestation.<bold>Results: </bold>Women who developed preeclampsia had significantly lower PGI-M levels throughout pregnancy, even at 13 to 16 weeks' gestation (long before the onset of clinical disease); their gestational age-adjusted levels were 17% lower than those of controls (95% confidence interval [CI], 6%-27%; P=.005). The Tx-M levels of preeclamptic women were not significantly higher overall (9% higher than those of controls; 95% CI, -3% to 23%; P=.14). The ratio of Tx-M to PGI-M, used to express relative vasoconstricting vs vasodilating effects, was 24% higher (95% CI, 6%-45%) in preeclamptic women throughout pregnancy (P=.007).<bold>Conclusions: </bold>Our results show that reduced PGI2 production, but not increased TxA2 production, occurs many months before clinical onset of preeclampsia. Aspirin trials may have failed because an increase in thromboxane production is not the initial anomaly. Future interventions should make correcting prostacyclin deficiency a major part of the strategy to balance the abnormal vasoconstrictor-vasodilator ratio present in preeclampsia. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROSTACYCLIN
KW  - THROMBOXANES
KW  - PREECLAMPSIA
KW  - MEDICINE
N1  - Accession Number: 2064533; Mills, James L. DerSimonian, Rebecca Raymond, Elizabeth Morrow, Jason D. Roberts II, L. Jackson Clemens, John D. Hauth, John C. Catalano, Patrick Sibai, Baha Curet, L.B. Levine, Richard J. Mills, J L 1 DerSimonian, R Raymond, E Morrow, J D Roberts, L J 2nd Clemens, J D Hauth, J C Catalano, P Sibai, B; Affiliation:  1: Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 7/28/99, Vol. 282 Issue 4, p356; Subject Term: PROSTACYCLIN; Subject Term: THROMBOXANES; Subject Term: PREECLAMPSIA; Subject Term: MEDICINE; Number of Pages: 7p; Illustrations: 1 Chart, 12 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107211613
T1  - A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy.
AU  - Freifeld A
AU  - Marchigiani D
AU  - Walsh T
AU  - Chanock S
AU  - Lewis L
AU  - Hiemenz J
AU  - Hiemenz S
AU  - Hicks JE
AU  - Gill V
AU  - Steinberg SM
AU  - Pizzo PA
Y1  - 1999/07/29/
N1  - Accession Number: 107211613. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Commentary: Ebell M. Are oral antibiotics effective for low-risk chemotherapy patients with fever and neutropenia? (EVID BASED PRACT) 1999 Nov; 2 (11): 8-9 2p. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Chemotherapy, Cancer -- Adverse Effects
KW  - Neutropenia -- Drug Therapy
KW  - Fever -- Drug Therapy
KW  - Antibiotics -- Therapeutic Use
KW  - Antibiotics -- Administration and Dosage
KW  - Febrile Neutropenia
KW  - Double-Blind Studies
KW  - Random Assignment
KW  - Fisher's Exact Test
KW  - Wilcoxon Rank Sum Test
KW  - Mantel-Haenszel Test
KW  - P-Value
KW  - Child, Preschool
KW  - Child
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Inpatients
KW  - Male
KW  - Female
KW  - Human
SP  - 305
EP  - 311
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 341
IS  - 5
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Md
U2  - PMID: 10423464.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107211613&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - NEWS
AU  - Mills, James L.
T1  - Heinz Berendes, 1925-1999.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/08//
VL  - 89
IS  - 8
M3  - Obituary
SP  - 1156
EP  - 1157
PB  - American Public Health Association
SN  - 00900036
AB  - The article presents an obituary for medical scientist Heinz Berendes.
KW  - BERENDES, Heinz
N1  - Accession Number: 2107152; Mills, James L. 1; Affiliation:  1: Pediatric Epidemiology Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md; Source Info: Aug1999, Vol. 89 Issue 8, p1156; People: BERENDES, Heinz; Number of Pages: 2p; Illustrations: 1 Black and White Photograph; Document Type: Obituary; Full Text Word Count: 1128
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Marcus, Pamela M.
AU  - Baird, Donna Day
AU  - Millikan, Robert C.
AU  - Moorman, Patricia G.
AU  - Qaqish, Bahjat
AU  - Newman, Beth
T1  - Adolescent Reproductive Events and Subsequent Breast Cancer Risk.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/08//
VL  - 89
IS  - 8
M3  - Article
SP  - 1244
EP  - 1247
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study investigated the relationship between reproductive events during adolescence and subsequent breast cancer risk. Methods. Logistic regression models used self-reported data from 862 case patients and 790 controls in the Carolina Breast Cancer Study. Results. Miscarriage, induced abortion, and full-term pregnancy before 20 years of age were not associated with breast cancer. Among premenopausal women, breast-feeding before 20 years of age was inversely associated with disease. Oral contraceptive use before 18 years of age was positively associated with disease risk among African American women only. Conclusions. Pregnancy during adolescence does not appear to influence breast cancer risk, but breast-feeding may. A possible increased breast cancer risk among African American women who used oral contraceptives as adolescents warrants further study. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HUMAN reproduction -- Endocrine aspects
KW  - TEENAGE girls
KW  - BREAST cancer
KW  - CANCER in women
KW  - LOGISTIC regression analysis
N1  - Accession Number: 2107171; Marcus, Pamela M. 1,2; Email Address: pml45q@nih.gov Baird, Donna Day 3 Millikan, Robert C. 2 Moorman, Patricia G. 2,4 Qaqish, Bahjat 5 Newman, Beth 2; Affiliation:  1: Biometry Branch, Division of Cancer Prevention, National Cancer Institute, Bethesda, Md  2: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill  3: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC  4: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn  5: Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill; Source Info: Aug1999, Vol. 89 Issue 8, p1244; Subject Term: HUMAN reproduction -- Endocrine aspects; Subject Term: TEENAGE girls; Subject Term: BREAST cancer; Subject Term: CANCER in women; Subject Term: LOGISTIC regression analysis; Number of Pages: 4p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 3514
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107147661
T1  - In memoriam. Heinz Berendes, 1925-1999.
AU  - Mills JL
Y1  - 1999/08//
N1  - Accession Number: 107147661. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; obituary. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074. 
KW  - Research, Medical
KW  - Epidemiology
KW  - Research Personnel
KW  - National Institutes of Health (U.S.)
KW  - Perinatal Care
KW  - Male
KW  - Berendes H
SP  - 1156
EP  - 1157
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 89
IS  - 8
CY  - Washington, District of Columbia
PB  - American Public Health Association
SN  - 0090-0036
AD  - Pediatric Epidemiology Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md
DO  - 10.2105/AJPH.89.8.1156
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107147776
T1  - Adolescent reproductive events and subsequent breast cancer risk.
AU  - Marcus PM
AU  - Baird DD
AU  - Millikan RC
AU  - Moorman PG
AU  - Qaqish B
AU  - Newman B
Y1  - 1999/08//
N1  - Accession Number: 107147776. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Funded in part through the following National Cancer Institute (NCI) grants: T32-CA09330 (Cancer Training Grant), R25-CA57726 (Cancer Prevention and Control Pre-Doctoral Fellowship), and P50-CA58223 (SPORE in Breast Cancer), and from the NCI Cancer Prevention and Control Fellowship Program. NLM UID: 1254074. 
KW  - Breast Neoplasms -- Epidemiology
KW  - Reproductive History
KW  - Pregnancy in Adolescence
KW  - Breast Neoplasms -- Etiology
KW  - Epidemiological Research
KW  - Population-Based Case Control
KW  - Interviews
KW  - Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Funding Source
KW  - Contraceptives, Oral -- Adverse Effects
KW  - Abortion, Spontaneous -- Complications
KW  - Abortion, Induced -- Adverse Effects
KW  - North Carolina
KW  - Breast Feeding -- Adverse Effects
KW  - Risk Factors
KW  - Blacks
KW  - Whites
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Pregnancy
KW  - Female
KW  - Human
SP  - 1244
EP  - 1247
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 89
IS  - 8
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study investigated the relationship between reproductive events during adolescence and subsequent breast cancer risk. METHODS: Logistic regression models used self-reported data from 862 case patients and 790 controls in the Carolina Breast Cancer Study. RESULTS: Miscarriage, induced abortion, and full-term pregnancy before 20 years of age were not associated with breast cancer. Among premenopausal women, breast-feeding before 20 years of age was inversely associated with disease. Oral contraceptive use before 18 years of age was positively associated with disease risk among African American women only. CONCLUSIONS: Pregnancy during adolescence does not appear to influence breast cancer risk, but breast-feeding may. A possible increased breast cancer risk among African American women who used oral contraceptives as adolescents warrants further study.
SN  - 0090-0036
AD  - Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Ste 344, 6130 Executive Blvd, MSC 7354, Bethesda, MD 20892-7354 (pm145q@nih.gov)
U2  - PMID: 10432916.
DO  - 10.2105/AJPH.89.8.1244
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 90787241
T1  - Ataxin 1 and ataxin 3 in neuronal intranuclear inclusion disease.
AU  - Lieberman, Andrew P.
AU  - Trojanowski, John Q.
AU  - Leonard, Debra G. B.
AU  - Chen, Ke-Lian
AU  - Barnett, Jeffrey L.
AU  - Leverenz, James B.
AU  - Bird, Thomas D.
AU  - Robitaille, Yves
AU  - Malandrini, Alessandro
AU  - Fischbeck, Kenneth H.
AU  - Lieberman, A P
AU  - Trojanowski, J Q
AU  - Leonard, D G
AU  - Chen, K L
AU  - Barnett, J L
AU  - Leverenz, J B
AU  - Bird, T D
AU  - Robitaille, Y
AU  - Malandrini, A
AU  - Fischbeck, K H
Y1  - 1999/08//
N1  - Accession Number: 90787241. Language: English. Entry Date: 20020920. Revision Date: 20161127. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7707449. 
KW  - Cells
KW  - Nerve Tissue Proteins -- Analysis
KW  - Neurodegenerative Diseases -- Pathology
KW  - Nuclear Proteins -- Analysis
KW  - Neurodegenerative Diseases
KW  - Female
KW  - Aged
KW  - DNA
KW  - Adult
KW  - Proteins
KW  - Human
KW  - Male
KW  - Immunohistochemistry
KW  - Middle Age
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 271
EP  - 273
JO  - Annals of Neurology
JF  - Annals of Neurology
JA  - ANN NEUROL
VL  - 46
IS  - 2
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
AB  - Neuronal intranuclear inclusion disease (NIID) is a multisystem neurodegenerative disorder characterized by large intranuclear aggregates in neurons of the central and peripheral nervous system. These ubiquitinated intranuclear inclusions are morphologically similar to the intraneuronal aggregates that have been identified in the CAG/polyglutamine expansion diseases. As rare aggregates in NIID contain a polyglutamine epitope, we further investigated the relationship between this disease and the CAG/polyglutamine expansion diseases. Here, we show that ataxin 1 and ataxin 3 proteins are recruited into aggregates in NIID in the absence of a CAG expansion in the SCA1 and SCA3 genes. These data support an association of NIID with the polyglutamine disorders and provide evidence of in vivo recruitment of proteins with polyglutamine tracts into intraneuronal aggregates.
SN  - 0364-5134
AD  - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
AD  - Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
AD  - Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, MI
AD  - Departments of Neurology, Psychiatry Behavioral Sciences, University of Washington School of Medicine, Seattle, WA
AD  - Department of Neurology, University of Washington School of Medicine Geriatrics Research Service, Veterans Affairs Medical Center, Seattle, WA
AD  - Department of Pathology, University of Montreal Departments of Neurosurgery and Neurology, McGill University, Montreal, Canada
AD  - Institute of Neurological Sciences, University of Siena, Siena, Italy
AD  - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
U2  - PMID: 10443897.
DO  - 10.1002/1531-8249(199908)46:2<271::AID-ANA21>3.0.CO;2-M
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Vgontzas, Alexandros N.
AU  - Mastorakos, George
AU  - Bixler, Edward O.
AU  - Kales, Anthony
AU  - Gold, Philip W.
AU  - Chrousos, George P.
T1  - Sleep deprivation effects on the activity of the hypothalamic–pituitary–adrenal and growth axes: potential clinical implications.
JO  - Clinical Endocrinology
JF  - Clinical Endocrinology
Y1  - 1999/08//
VL  - 51
IS  - 2
M3  - Article
SP  - 205
EP  - 215
PB  - Wiley-Blackwell
SN  - 03000664
AB  - OBJECTIVES Although several studies have shown that sleep deprivation is associated with increased slow wave sleep during the recovery night, the effects of sleep deprivation on cortisol and growth hormone (GH) secretion the next day and recovery night have not been assessed systematically. We hypothesized that increased slow wave sleep postsleep deprivation is associated with decreased cortisol levels and that the enhanced GH secretion is driven by the decreased activity of the HPA axis. DESIGN AND SUBJECTS After four consecutive nights in the Sleep Laboratory, 10 healthy young men were totally deprived of sleep during the fifth night, and then allowed to sleep again on nights six and seven. Twenty-four hour blood sampling was performed serially every 30 minutes on the fourth day, immediately following the previous night of sleep and on the sixth day, immediately after sleep deprivation. MEASUREMENT Eight-hour sleep laboratory recording, including electroencephologram, electro-oculogram and electromyogram. Plasma cortisol and GH levels using specific immunoassay techniques. RESULTS Mean plasma and time-integrated (AUC) cortisol levels were lower during the postdeprivation nighttime period than on the fourth night (P < 0.05). Pulsatile analysis showed significant reduction of both the 24 h and daytime peak area (P < 0.05) and of the pulse amplitude (P < 0.01), but not of the pulse frequency. Also, the amount of time-integrated GH was significantly higher for the first 4 h of the postdeprivation night compared to the predeprivation night (P < 0.05). Cross-correlation analyses between the absolute values of the time-series of each hormone value and percentage of each sleep stage per half hour revealed that slow wave sleep was negatively correlated with cortisol and positively correlated with GH with slow wave sleep preceding the secretion of these hormones. In contrast, indices of sleep disturbance, i.e. wake and stage 1 sleep, were positively correlated with... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Endocrinology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SLEEP deprivation
KW  - HYDROCORTISONE
KW  - SOMATOTROPIN
KW  - PHYSIOLOGY
N1  - Accession Number: 5313743; Vgontzas, Alexandros N. 1 Mastorakos, George 2 Bixler, Edward O. 1 Kales, Anthony 1 Gold, Philip W. 3 Chrousos, George P. 4; Affiliation:  1: Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey, USA,  2: Endocrine Unit, Evgenidion Hospital, Athens University, Athens, Greece,  3: Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, USA,  4: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA; Source Info: Aug1999, Vol. 51 Issue 2, p205; Subject Term: SLEEP deprivation; Subject Term: HYDROCORTISONE; Subject Term: SOMATOTROPIN; Subject Term: PHYSIOLOGY; Number of Pages: 11p; Document Type: Article
L3  - 10.1046/j.1365-2265.1999.00763.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Pequegnat, Willo
AU  - Stover, Ellen
T1  - Considering Women's Contextual and Cultural Issues in HIV/STD Prevention Research.
JO  - Cultural Diversity & Ethnic Minority Psychology
JF  - Cultural Diversity & Ethnic Minority Psychology
Y1  - 1999/08//
VL  - 5
IS  - 3
M3  - Article
SP  - 287
EP  - 291
SN  - 10999809
AB  - HIV prevention issues for women and particularly women of color are multifaceted and far reaching. This article reviews 5 themes that emerge from the articles in this special issue. The 1st theme is culture, health, and sexuality, which examines the gender stereotypes, cultural expectations, and social, political, and economic conditions that impact significantly on women's reproductive decision making, self-protective behaviors, and vulnerability to sexually transmitted infections, including HIV. The 2nd theme is trauma and revictimization, which involves the relationship between prior sexual and physical abuse and its link to current HIV/sexually transmitted disease risk behavior. The multiple roles of women is the 3rd theme that emerges from these articles because women are often de facto designated as the caregivers in a family. The importance of the further development of female-controlled barrier methods is the 4th theme in this special issue because women are often at risk because of the behaviors of their partners rather than their own behaviors. Finally, the last theme is one of gender dynamics in HIV, where there is strong evidence that there is more efficient transmission of HIV from men to women and that women with lower viral loads progress more rapidly to AIDS than men. This article ends with a research agenda based on the collective wisdom in the articles in this special issue. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cultural Diversity & Ethnic Minority Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV infections -- Prevention
KW  - HIV-positive women
KW  - DECISION making
KW  - SEXUALLY transmitted diseases
KW  - TRAUMATISM
KW  - CAREGIVERS
N1  - Accession Number: 24779902; Pequegnat, Willo 1; Email Address: wpequegn@nih.gov Stover, Ellen 1; Affiliation:  1: National Institute of Mental Health; Source Info: Aug99, Vol. 5 Issue 3, p287; Subject Term: HIV infections -- Prevention; Subject Term: HIV-positive women; Subject Term: DECISION making; Subject Term: SEXUALLY transmitted diseases; Subject Term: TRAUMATISM; Subject Term: CAREGIVERS; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson, Norman J.
AU  - Sorlie, Paul D.
AU  - Backlund, Eric
T1  - THE IMPACT OF SPECIFIC OCCUPATION ON MORTALITY IN THE U.S. NATIONAL LONGITUDINAL MORTALITY STUDY.
JO  - Demography
JF  - Demography
Y1  - 1999/08//
VL  - 36
IS  - 3
M3  - Article
SP  - 355
EP  - 367
SN  - 00703370
AB  - This article investigates relationships between occupational mortality differences and income, education, and social status in the U.S. using U.S. National Longitudinal Mortality Study. Determining the impact of occupation on morbidity and mortality requires the understanding of a complex set of relationships involving the workplace, the environment, and the individual. Occupation consumes a large portion of daily activities, provides the means for material support, and is a determinant of lifestyle and social status. Because of inherent differences in occupations and exposures that accumulate over a lifetime, conditions in the workplace affect one's health and survival. Occupations may also exert positive influences on health and survival. Both the income and prestige received from an occupation influence choice of community environment and a social circle of friends. The U.S. National Longitudinal Mortality Study is a prospective study of mortality occurring in combined samples of the noninstitutionalized U.S. population. It consists of samples taken from selected Current Population Surveys conducted by the U.S. Bureau of the Census.
KW  - OCCUPATIONAL mortality
KW  - LIFESTYLES
KW  - SOCIAL status
KW  - OCCUPATIONAL surveys
KW  - WORK environment
KW  - UNITED States
N1  - Accession Number: 2249306; Johnson, Norman J. 1; Email Address: norman.j.johnson@ccmail.census.gov Sorlie, Paul D. 2 Backlund, Eric 3; Affiliation:  1: Demographic Statistical Methods Division, Room 3725-3, U.S. Bureau of the Census, Washington. DC 2O233.  2: National Heart. Lung, and Blood Institute, Bathesda.  3: Demographic Statistical Methods Division, U.S. Bureau of the Census.; Source Info: Aug99, Vol. 36 Issue 3, p355; Subject Term: OCCUPATIONAL mortality; Subject Term: LIFESTYLES; Subject Term: SOCIAL status; Subject Term: OCCUPATIONAL surveys; Subject Term: WORK environment; Subject Term: UNITED States; Number of Pages: 13p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Melnick, Ronald L.
T1  - Introduction-Workshop on Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels.
JO  - Environmental Health Perspectives
JF  - Environmental Health Perspectives
Y1  - 1999/08//
VL  - 107
IS  - 8
M3  - Article
SP  - 603
EP  - 604
PB  - Superintendent of Documents
SN  - 00916765
N1  - Accession Number: 96431056; Melnick, Ronald L. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina USA; Issue Info: Aug1999, Vol. 107 Issue 8, p603; Number of Pages: 2p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Indic, P.
AU  - Pratap, R.
AU  - Nampoori, V.P.N.
AU  - Pradhan, N.
T1  - SIGNIFICANCE OF TIME SCALES IN NONLINEAR DYNAMICAL ANALYSIS OF ELECTROENCEPHALOGRAM SIGNALS.
JO  - International Journal of Neuroscience
JF  - International Journal of Neuroscience
Y1  - 1999/08//
VL  - 99
IS  - 1-4
M3  - Article
SP  - 181
PB  - Taylor & Francis Ltd
SN  - 00207454
AB  - Proposes to show that the time series obtained from biological systems such as human brain are invariably nonstationary because of different time scales involved in the dynamical process.  Global analysis of the electroencephalogram data obtained from the eight locations of the skull space; Sensitivity of the dynamical parameters to the time scales.
KW  - ELECTROENCEPHALOGRAPHY
KW  - BRAIN -- Research
KW  - chaotic dynamics
KW  - EEG
KW  - entropy
KW  - time scale
N1  - Accession Number: 4020151; Indic, P. 1 Pratap, R. 2 Nampoori, V.P.N. 2 Pradhan, N. 3; Affiliation:  1: Department of Electronics, Cochin University of Science and Technology, Kerala, India  2: Centre for Interdisciplinary Studies, Cochin University of Science and Technology, Kerala, India  3: National Institute of Mental Health and Neurosciences, Bangladore, India; Source Info: 1999, Vol. 99 Issue 1-4, p181; Subject Term: ELECTROENCEPHALOGRAPHY; Subject Term: BRAIN -- Research; Author-Supplied Keyword: chaotic dynamics; Author-Supplied Keyword: EEG; Author-Supplied Keyword: entropy; Author-Supplied Keyword: time scale; Number of Pages: 14p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article; Full Text Word Count: 4791
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Liddington, R.
AU  - Pannifer, A.
AU  - Hanna, P.
AU  - Leppla, S.
AU  - Collier, R. J.
T1  - Crystallographic studies of the anthrax lethal toxin.
JO  - Journal of Applied Microbiology
JF  - Journal of Applied Microbiology
Y1  - 1999/08//
VL  - 87
IS  - 2
M3  - Article
SP  - 282
EP  - 282
PB  - Wiley-Blackwell
SN  - 13645072
AB  - Anthrax lethal toxin comprises two proteins: protective antigen (PA; MW 83 kDa) and lethal factor (LF; MW 87 kDa). We have recently determined the crystal structure of the 735-residue PA in its monomeric and heptameric forms (Petosa et al. 1997). It bears no resemblance to other bacterial toxins of known three-dimensional structure, and defines a new structural class which includes homologous toxins from other Gram-positive bacteria. We have proposed a model of membrane insertion in which the water-soluble heptamer undergoes a substantial pH-induced conformational change involving the creation of a 14-stranded β-barrel. Recent work by Collier’s group (Benson et al. 1998) lends strong support to our model of membrane insertion. ‘Lethal factor’ is the catalytic component of anthrax lethal toxin. It binds to the surface of the cell-bound PA heptamer and, following endocytosis and acidification of the endosome, translocates to the cytosol. We have made substantial progress towards an atomic resolution crystal structure of LF. Progress towards a structure of the 7:7 translocation complex between the PA heptamer and LF will also be discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TOXINS
KW  - PROTEINS
KW  - GENETICS
N1  - Accession Number: 5588272; Liddington, R. 1 Pannifer, A. 1 Hanna, P. 2 Leppla, S. 3 Collier, R. J. 4; Affiliation:  1: Department of Biochemistry, University of Leicester, Leicester, UK,  2: Duke University Medical Center, Durham, NC,  3: Laboratory of Microbial Ecology, National Institutes of Health, Bethesda, MD and  4: Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, MA, USA; Source Info: Aug99, Vol. 87 Issue 2, p282; Subject Term: TOXINS; Subject Term: PROTEINS; Subject Term: GENETICS; Number of Pages: 1p; Document Type: Article
L3  - 10.1046/j.1365-2672.1999.00888.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Duesbery, N. S.
AU  - Woude, G. F. Vande
T1  - Anthrax lethal factor causes proteolytic inactivation of mitogen-activated protein kinase kinase.
JO  - Journal of Applied Microbiology
JF  - Journal of Applied Microbiology
Y1  - 1999/08//
VL  - 87
IS  - 2
M3  - Article
SP  - 289
EP  - 293
PB  - Wiley-Blackwell
SN  - 13645072
AB  - A search of the National Cancer Institute’s Anti-Neoplastic Drug Screen for compounds with an inhibitory profile similar to that of the mitogen-activated protein kinase kinase (MAPKK) inhibitor PD098059 yielded anthrax lethal toxin. Anthrax lethal factor was found to inhibit progesterone-induced meiotic maturation of frog oocytes by preventing the phosphorylation and activation of mitogen-activated protein kinase (MAPK). Similarly, lethal toxin prevented the activation of MAPK in serum stimulated, ras-transformed NIH3T3 cells. In vitro analyses using recombinant proteins indicated that lethal factor proteolytically modified the NH2-terminus of both MAPKK1 and 2, rendering them inactive and hence incapable of activating MAPK. The consequences of this inactivation upon meiosis and transformed cells are also discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN kinases
KW  - PROTEASE inhibitors
N1  - Accession Number: 5588278; Duesbery, N. S. 1 Woude, G. F. Vande 2; Affiliation:  1: ABL-Basic Research Program, and  2: National Cancer Institute, Division of Basic Sciences, NCI-FCRDC, Frederick, MD, USA; Source Info: Aug99, Vol. 87 Issue 2, p289; Subject Term: PROTEIN kinases; Subject Term: PROTEASE inhibitors; Number of Pages: 5p; Illustrations: 4 Black and White Photographs, 1 Graph; Document Type: Article
L3  - 10.1046/j.1365-2672.1999.00892.x
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DB  - aph
ER  - 

TY  - JOUR
AU  - Gomes, Ignatius
AU  - Xiong, Wen
AU  - Miki, Toru
AU  - Rosner, Marsha Rich
T1  - A Proline- and Glutamine-Rich Protein Promotes Apoptosis in Neuronal Cells.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/08//
VL  - 73
IS  - 2
M3  - Article
SP  - 612
EP  - 622
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Abstract: During development, excess neurons are eliminated by programmed cell death. Similarly, conditionally immortalized (SV40-Tts) rat hippocampal and septal cells undergo cell death following differentiation with several factors such as fibroblast growth factor, constitutively activated Raf-1, or phorbol esters. The mechanism by which cell death occurs has not been identified. Using RNA differential display, we have identified and characterized a novel immediate early gene (denoted PQR for proline- and glutamine-rich) induced during differentiation of both rat hippocampal and septal cell lines. The 44-kDa PQR protein, rich in PQ, PH, and QQ repeats, is homologous to a murine protein (TDAG51) required for Fas-mediated apoptosis in T cells. To determine whether PQR acts as a mediator of apoptosis in neuronal cells, the hippocampal H19-7 cells were microinjected with either a plasmid expressing PQR cDNA or an antibody against PQR. Microinjection of differentiating H19-7 cells with a neutralizing antibody against PQR increased the number of surviving cells by 50%. Transient expression of PQR in both differentiating and nondifferentiating H19-7 cells decreased the number of surviving cells by 35-50% ; this reduction was reversed by microinjection of PQR antibody. Finally, levels of Fas transcripts are not increased in the neuronal cells, indicating that the mechanism of action differs from that in T cells. These results demonstrate that PQR can be induced by growth factors and differentiating agents and can itself induce apoptosis in hippocampal H19-7 cells. Furthermore, these data suggest that PQR can function more generally as a mediator of apoptosis and provide a possible mechanism for induction of programmed cell death during neuronal development. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - APOPTOSIS
KW  - CELL death
KW  - NEURONS
KW  - PROTEINS
KW  - Apoptosis
KW  - Neuronal development
KW  - Programmed cell death
KW  - Proline- and glutaminerich protein
N1  - Accession Number: 7287371; Gomes, Ignatius Xiong, Wen Miki, Toru Rosner, Marsha Rich 1,2; Affiliation:  1: Department of Molecular Pharmacology, Stanford Medical School, Stanford University, Palo Alto, California, U.S.A.  2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug99, Vol. 73 Issue 2, p612; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: NEURONS; Subject Term: PROTEINS; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Neuronal development; Author-Supplied Keyword: Programmed cell death; Author-Supplied Keyword: Proline- and glutaminerich protein; Number of Pages: 11p; Document Type: Article
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DB  - aph
ER  - 

TY  - JOUR
ID  - 107216582
T1  - Observations. Atherosclerosis, Russell Ross and the passion of science.
AU  - Slavkin HC
Y1  - 1999/08//
N1  - Accession Number: 107216582. Language: English. Entry Date: 19991001. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Wound Healing
KW  - Research, Medical -- History
KW  - Arteriosclerosis -- Physiopathology
KW  - Information Resources
KW  - Dentists
KW  - Male
KW  - United States
SP  - 1219
EP  - 1222
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 8
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, MD, 20892-2290
U2  - PMID: 10491935.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107231424
T1  - Traumatic rupture of the descending thoracic aorta associated with severe pulmonary contusion: requirement of full cardiopulmonary bypass for life support during surgical repair.
AU  - Nguyen DM
AU  - Hill AB
AU  - Chughtai T
AU  - Robinson R
AU  - Mulder DS
Y1  - 1999/08//1999 Aug
N1  - Accession Number: 107231424. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376373. 
KW  - Aortic Rupture -- Surgery
KW  - Cardiopulmonary Bypass
KW  - Accidents, Traffic
KW  - Aortic Rupture -- Radiography
KW  - Adult
KW  - Male
SP  - 406
EP  - 407
JO  - Journal of Trauma
JF  - Journal of Trauma
JA  - J TRAUMA
VL  - 47
IS  - 2
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0022-5282
AD  - National Cancer Institute, National Institutes of Health, Room 2C708, Building 10, 10 Center Drive, MSC1502, Bethesda, MD, 20892-1502
U2  - PMID: 10452484.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107228137
T1  - New and worsening conditions and change in physical and cognitive performance during weekly evaluations over 6 months: the Women's Health and Aging Study.
AU  - Guralnik JM
AU  - Ferrucci L
AU  - Penninx BWJ
AU  - Kasper JD
AU  - Leveille SG
AU  - Bandeen-Roche K
AU  - Fried LP
Y1  - 1999/08//
N1  - Accession Number: 107228137. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al); Geriatric Depression Scale (GDS). Grant Information: Contract N01-AG-1-2112 from the National Institute on Aging. NLM UID: 9502837. 
KW  - Cognition -- In Old Age
KW  - Functional Status -- Trends -- In Old Age
KW  - Prospective Studies
KW  - Geriatric Functional Assessment
KW  - Neuropsychological Tests
KW  - Data Analysis Software
KW  - Data Analysis, Computer Assisted
KW  - Regression
KW  - Intraclass Correlation Coefficient
KW  - Descriptive Statistics
KW  - Linear Regression
KW  - McNemar's Test
KW  - Goodness of Fit Chi Square Test
KW  - Chronic Disease -- Epidemiology -- In Old Age
KW  - Odds Ratio
KW  - P-Value
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Funding Source
KW  - Human
SP  - M410
EP  - 22
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 54A
IS  - 8
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Gateway Bldg., Suite 3C-309, 7201 Wisconsin Ave, Bethesda, MD 20892-9205
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DB  - rzh
ER  - 

TY  - JOUR
AU  - Wilhelm, Martin
AU  - O'Brien, Susan
AU  - Rios, Mary Beth
AU  - Estey, Elihu
AU  - Keating, Michael J.
AU  - Plunkett, William
AU  - Sorenson, Mel
AU  - Kantarjian, Hagop M.
T1  - Phase I Study of Arabinosyl-5-Azacytidine (Fazarabine) in Adult Acute Leukemia and Chronic Myelogenous Leukemia in Blastic Phase.
JO  - Leukemia & Lymphoma
JF  - Leukemia & Lymphoma
Y1  - 1999/08//
VL  - 34
IS  - 5/6
M3  - Article
SP  - 511
EP  - 518
PB  - Taylor & Francis Ltd
SN  - 10428194
AB  - Fazarabine has demonstrated a broad spectrum of antitumor activity in experimental models including P388 and L1210 cell lines. Previous phase I clinical trials using a 3-day continuous infusion schedule of Fazarabine have shown myelosuppression to be the dose limiting toxicity in solid tumors. Based on this clinical and preclinical experience we designed a phase I study to determine the toxicity, maximum tolerated dose (MTD), and antileukemic efficacy of Fazarabine using a 3-day continuous infusion schedule in patients with refractory or relapsed acute leukemia or chronic myelogenous (CML) in blastic phase. Adults with a diagnosis of acute leukemia or blastic phase CML who were refractory or had relapsed on salvage chemotherapy were entered on study. Fazarabine was administered as a continuous infusion over 3 days every 3 to 4 weeks. The initial dose was 2 mg/m² /hour x 72 hours. Results showed that the MTD was 425 mg/m²/hour infused over 72 hours every 3 to 4 weeks. At this dose level neurotoxicity and fluid overload were the dose hmiting toxicities. Among 71 patients treated, we observe(j one complete remission, one partial remission and one hematologic improvement. No obvious dose response relationship could be determined. In conclusion, Fazarabine has not shown a beneficial effect in the therapy of acute leukemia. Since 71 patients and 20 dose levels were required to determine the MTD of Fazarabine, a reassessment of our phase I study designs should be considered to provide patients with better potential toxic: therapeutic benefits in such trials. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia & Lymphoma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHRONIC myeloid leukemia
KW  - ANTINEOPLASTIC agents
KW  - ACUTE leukemia
KW  - TOXICOLOGY
KW  - DRUG therapy
KW  - arabinosyl-5-azacytidine
KW  - fazarabine
KW  - leukemia-acute
KW  - salvage therapy
N1  - Accession Number: 17473936; Wilhelm, Martin 1 O'Brien, Susan 2 Rios, Mary Beth 2 Estey, Elihu 2 Keating, Michael J. 2 Plunkett, William 2 Sorenson, Mel 3 Kantarjian, Hagop M. 2; Affiliation:  1: Medizinische Poliklinik University of Wurzburg, Wurzburg, Germany  2: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas  3: National Cancer Institute, Bethesda, Maryland, USA; Source Info: Aug99, Vol. 34 Issue 5/6, p511; Subject Term: CHRONIC myeloid leukemia; Subject Term: ANTINEOPLASTIC agents; Subject Term: ACUTE leukemia; Subject Term: TOXICOLOGY; Subject Term: DRUG therapy; Author-Supplied Keyword: arabinosyl-5-azacytidine; Author-Supplied Keyword: fazarabine; Author-Supplied Keyword: leukemia-acute; Author-Supplied Keyword: salvage therapy; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article; Full Text Word Count: 4138
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ER  - 

TY  - JOUR
AU  - Kanegane, Hirokazu
AU  - Miyawaki, Toshio
AU  - Yachie, Akihiro
AU  - Oh-Ishi, Tsutomu
AU  - Bhatia, Kishor
AU  - Tosato, Giovanna
T1  - Development of EBV-Positive T-Cell Lymphoma Following Infection of Peripheral Blood T Cells with EBV.
JO  - Leukemia & Lymphoma
JF  - Leukemia & Lymphoma
Y1  - 1999/08//
VL  - 34
IS  - 5/6
M3  - Article
SP  - 603
EP  - 607
PB  - Taylor & Francis Ltd
SN  - 10428194
AB  - Chronic active Epstein-Barr virus (EBV) infection is manifested clinically by the persistence of infectious mononucleosis-like symptoms or its complications for a prolonged period ranging from one to several years. This syndrome may include severe disease manifestations and can be fatal. The role of EBV in the pathogenesis of chronic active EBV infection has been unclear. We investigated two Japanese patients with severe chronic active EBV infection who subsequently developed EBV-positive T-cell lymphoma. We found that the patients had evidence of EBV infection in the peripheral blood CD4* T-cells 19 and 3 months, respectively, before the T-cell lymphoma was diagnosed. The lymphomas were infected with monoclonal EBV and expressed the EBV latency genes EBNA-1, LMP-i, and LMP-2A, a virus latency pattern referred to as latency IL Genetic studies showed that the virus detected in the T-cell lymphoma was indistinguishable from the virus in the peripheral blood CD4+T-cells. These studies support an important pathogenetic role of T-cell infection with EBV in chronic active EBV infection and in the EBV-positive T-cell lymphoma that followed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Leukemia & Lymphoma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EPSTEIN-Barr virus diseases
KW  - T cells
KW  - HERPESVIRUS diseases
KW  - LYMPHOPROLIFERATIVE disorders
KW  - LYMPHOMAS
KW  - chronic active EBV infection
KW  - EBV-positive T-cell lymphoma
KW  - Epstein-Barr virus
N1  - Accession Number: 17473979; Kanegane, Hirokazu 1; Email Address: kanegane@ms.toyama-mpu.ac.jp Miyawaki, Toshio 1 Yachie, Akihiro 2 Oh-Ishi, Tsutomu 3 Bhatia, Kishor 4 Tosato, Giovanna 5; Affiliation:  1: Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 9361-8194  2: School of Health Science, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-0934  3: Saitama Children's Medical Center, Iwatsuki, Saitama 339-0077, Japan  4: Pediatric Oncology Branch, National Cancer Institute, National Institute of Health  5: Division of Hematologic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892, U.S.A; Source Info: Aug99, Vol. 34 Issue 5/6, p603; Subject Term: EPSTEIN-Barr virus diseases; Subject Term: T cells; Subject Term: HERPESVIRUS diseases; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: LYMPHOMAS; Author-Supplied Keyword: chronic active EBV infection; Author-Supplied Keyword: EBV-positive T-cell lymphoma; Author-Supplied Keyword: Epstein-Barr virus; Number of Pages: 5p; Illustrations: 1 Black and White Photograph, 1 Diagram; Document Type: Article; Full Text Word Count: 2810
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ER  - 

TY  - JOUR
AU  - Mirsky, Allan F.
AU  - Pascualvaca, Daisy M.
AU  - Duncan, Connie C.
AU  - French, Louis M.
T1  - A model of attention and its relation to ADHD<FNR></FNR><FN>This article is a US Government work and, as such, is in the public domain in the United States of America. </FN>.
JO  - Mental Retardation & Developmental Disabilities Research Reviews
JF  - Mental Retardation & Developmental Disabilities Research Reviews
Y1  - 1999/08//
VL  - 5
IS  - 3
M3  - Article
SP  - 169
EP  - 176
PB  - John Wiley & Sons, Inc.
SN  - 10804013
AB  - We present a neuropsychological model of attention in normal and disordered states, including attention deficit hyperactivity disorder (ADHD). The model is based on a factor analysis of data derived from more than 600 children and adults. The robustness of the model is supported by its replication in a number of studies and its application in numerous investigations. It divides attention into a number of elements or factors including the capacities of encoding , focusing, and executing responses, sustaining attention, shifting attention, as well as a measure of response stability . The factors are assessed by measures derived from neuropsychological tests; we have posited a system of brain structures that maintains the elements of attention, each of which may be supported by a distinct cerebral region. We illustrate the use of the model in an investigation in progress of children referred to an inner-city family clinic for evaluation of ADHD. The ADHD study indicates that a number of aspects of attention are impaired in children diagnosed with ADHD, and that the deficient attention is probably not attributable to learning disorders. We also speculate on the possible role of immaturity of brain development in ADHD. MRDD Research Reviews 1999;5:169–176. Published 1999 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MODELS & modelmaking
KW  - NEUROPSYCHOLOGY
KW  - ATTENTION-deficit hyperactivity disorder
KW  - NEUROPSYCHOLOGICAL tests
KW  - LEARNING disabilities
KW  - ADHD
KW  - attention
KW  - learning disorders.
KW  - neuropsychology
N1  - Accession Number: 11782008; Mirsky, Allan F. 1; Email Address: Allan_Mirsky@nih.gov Pascualvaca, Daisy M. 1 Duncan, Connie C. 1,2 French, Louis M. 1; Affiliation:  1: Section on Clinical and Experimental Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Maryland.  2: Clinical Psychophysiology and Psychopharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Betheala, Maryland.; Source Info: 1999, Vol. 5 Issue 3, p169; Subject Term: MODELS & modelmaking; Subject Term: NEUROPSYCHOLOGY; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: NEUROPSYCHOLOGICAL tests; Subject Term: LEARNING disabilities; Author-Supplied Keyword: ADHD; Author-Supplied Keyword: attention; Author-Supplied Keyword: learning disorders.; Author-Supplied Keyword: neuropsychology; Number of Pages: 8p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107220828
T1  - A thoroughly modern gage.
AU  - Dimitrov M
AU  - Phipps M
AU  - Zahn TP
AU  - Grafman J
Y1  - 1999/08//
N1  - Accession Number: 107220828. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images; tables/charts. Journal Subset: Allied Health; Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9511374. 
KW  - Frontal Lobe -- Injuries
KW  - Social Behavior
KW  - Frontal Lobe -- Radiography
KW  - Adult
KW  - Middle Age
KW  - Male
SP  - 345
EP  - 354
JO  - Neurocase (Psychology Press)
JF  - Neurocase (Psychology Press)
JA  - NEUROCASE
VL  - 5
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - Taylor & Francis Ltd
AB  - We describe a 50-year-old male patient (MGS) with a right frontal ventromedial lesion who showed preserved general cognitive, abstract thinking and problem-solving abilities, in contrast to gross impairment in his social competence, social decision making and social conduct. MGS also demonstrated diminished sensitivity to socially relevant stimuli and situational nuances, impairment in sexual behavior, lost sense of responsibility, and disinhibition. We interpret this neurobehavioral profile, identical to the one of the famous 19th century patient Phineas Gage, in the light of the hypothesis that emotion and social conduct regulation depend on the ventromedial frontal cortex.
SN  - 1355-4794
AD  - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Harris, Lester
AU  - Sullivan, Michael
AU  - Hatfield, Dolph
T1  - Directed Molecular Evolution.
JO  - Origins of Life & Evolution of the Biosphere
JF  - Origins of Life & Evolution of the Biosphere
Y1  - 1999/08//
VL  - 29
IS  - 4
M3  - Article
SP  - 425
EP  - 435
SN  - 01696149
AB  - We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutionary constraints on the DNA sequences themselves, thus retaining these sequences and governing the direction of the evolutionary process. Therefore, we propose that prebiotic, template-directed autocatalytic synthesis of mutally cognate peptides and polynucleotides resulted in their amplification and evolutionary conservation in contemporary prokaryotic and eukaryotic organisms as a genetic regulatory apparatus. If this proposal is correct, then the relationships between the sequences in DNA coding for these interactions constitute a life code of which the genetic code is only one aspect of the many related interactions encoded in DNA. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Origins of Life & Evolution of the Biosphere is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1  - Accession Number: 52534968; Harris, Lester 1; Sullivan, Michael 1; Hatfield, Dolph 2; Email Address: harrislf@sp.msl.umn.edu; hatfield@dc37a.nci.nih.gov; Affiliations: 1: David F. Hickok Memorial Cancer Research Laboratory, Abbott Northwestern Hospital, 800 E. 28th St. Minneapolis 55407 U.S.A.; 2: Section on the Molecular Biology of Selenium, Laboratory of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda 20892 U.S.A.; Issue Info: Aug1999, Vol. 29 Issue 4, p425; Number of Pages: 11p; Document Type: Article
L3  - 10.1023/A:1006683409144
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DB  - eih
ER  - 

TY  - JOUR
AU  - Liu, Xianchen
AU  - Kurita, Hiroshi
AU  - Sun, Zhenxiao
AU  - Wang, Fuxi
T1  - Risk factors for psychopathology among Chinese children.
JO  - Psychiatry & Clinical Neurosciences
JF  - Psychiatry & Clinical Neurosciences
Y1  - 1999/08//
VL  - 53
IS  - 4
M3  - Article
SP  - 497
EP  - 503
PB  - Wiley-Blackwell
SN  - 13231316
AB  - AbstractThe present study was designed to examine the family environment and child characteristics associated with psychopathology among Chinese children. A large epidemiological sample of 1695 children aged 6–11 was drawn from 12 elementary schools in Linyi Prefecture of China. Parents completed the Child Behaviour Checklist, the Family Environment Scale, and a self-administered questionnaire including a number of items with regard to family, parental, and child characteristics. Results indicated that the overall prevalence of child psychopathology was 17.2%. Logistic regression analyses showed that a number of family and parental, as well as prenatal, perinatal and postnatal risk factors had significant association with child psychopathology. The most notable risks were derived from poor parental rearing with regard to the child’s misbehaviour, low birthweight, and poor marital relations of the parents after controlling for other factors. These findings are consistent with previously reported risk factors for child psychopathology, highlighting the importance of family and early childhood intervention as a measure to prevent child psychopathology in China. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILD psychopathology
KW  - CHILD rearing
KW  - PSYCHOLOGICAL aspects
KW  - CHINA
KW  - children
KW  - logistic regression
KW  - psychopathology
KW  - risk factors
N1  - Accession Number: 5167808; Liu, Xianchen 1,2,3 Kurita, Hiroshi 2 Sun, Zhenxiao 4 Wang, Fuxi 4; Affiliation:  1: Department of Psychiatry, Shandong Medical University, Jinan, China,  2: Department of Mental Health, University of Tokyo, Tokyo, Japan,  3: National Institute of Mental Health, Ichikawa, and  4: Linyi Mental Health Center, Linyi, China; Source Info: Aug99, Vol. 53 Issue 4, p497; Subject Term: CHILD psychopathology; Subject Term: CHILD rearing; Subject Term: PSYCHOLOGICAL aspects; Subject Term: CHINA; Author-Supplied Keyword: children; Author-Supplied Keyword: logistic regression; Author-Supplied Keyword: psychopathology; Author-Supplied Keyword: risk factors; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
L3  - 10.1046/j.1440-1819.1999.00579.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5167808&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Ishigooka, J.
AU  - Ishigooka, Jun
AU  - Suzuki, Makihiko
AU  - Isawa, Shinano
AU  - Muraoka, Hideo
AU  - Murasaki, Mitsukuni
AU  - Okawa, Masako
T1  - Epidemiological study on sleep habits and insomnia of new outpatients visiting general hospitals in Japan.
JO  - Psychiatry & Clinical Neurosciences
JF  - Psychiatry & Clinical Neurosciences
Y1  - 1999/08//
VL  - 53
IS  - 4
M3  - Article
SP  - 515
EP  - 522
PB  - Wiley-Blackwell
SN  - 13231316
AB  - AbstractA large scale epidemiological survey of sleep habits, specifically for insominia, was conducted using 6277 new outpatients from 11 general hospitals in Japan. They were requested to answer a questionnaire newly designed for this study, which consisted of 34 questions concerning socio-demographic characteristics, current medical conditions, sleep habits, current or past sleep complaints, symptoms of parasomnia, use of hypnotics/anxiolytics and other aspects of daily life. Insomnia was the focus of analysis using χ2 statistics and, additionally, logistic regression to explore the predictors of insomnia. Bedtime was 23:30 and wake-up time was 6:35 on average, with a mean sleep time of 6.77 h on weekdays. The number of subjects with current sleep complaints was 1276, of which 735 (11.7% of the total sample) had insomnia lasting for 1 month or more. Only 37.6% of those were taking hypnotics and/or anxiolytics. Old age, female sex, neurology, psychiatry, early bedtime, late wake-up time, living alone and dissatisfication with the bedroom environment for sleep were found to be associated with long-term insomnia. This study helps to provide a framework for further studies using the general population. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - INSOMNIACS
KW  - SLEEP -- Research
KW  - epidemiology
KW  - general hospital
KW  - insomnia
KW  - sleep habits
N1  - Accession Number: 5167809; Ishigooka, J. Ishigooka, Jun 1 Suzuki, Makihiko 2 Isawa, Shinano 1 Muraoka, Hideo 1 Murasaki, Mitsukuni 1 Okawa, Masako 3; Affiliation:  1: Department of Psychiatry, Kitasato University School of Medicine,  2: Kitasato University School of Allied Health Sciences, Sagamihara and  3: Department of Psychophysiology, National Institute of Mental Health, Ichikawa, Japan; Source Info: Aug99, Vol. 53 Issue 4, p515; Subject Term: INSOMNIACS; Subject Term: SLEEP -- Research; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: general hospital; Author-Supplied Keyword: insomnia; Author-Supplied Keyword: sleep habits; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
L3  - 10.1046/j.1440-1819.1999.00578.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5167809&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jahnke, G.
AU  - Marr, M.
AU  - Myers, C.
AU  - Wilson, R.
AU  - Travlos, G.
AU  - Price, C.
T1  - Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/08//
VL  - 50
IS  - 2
M3  - Article
SP  - 271
EP  - 279
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Melatonin (MEL) is a widely used, over-the-counter sleep aid, and it has putative contraceptive, antioxidant, antiaging, and anticancer effects. The developmental toxicity potential for repeated oral doses of MEL had not previously been evaluated. In the present studies, time-mated, Sprague-Dawley-derived (CD®) rats were administered MEL or vehicle by gavage on gestation days (gd) 6-19. MEL-treated groups received 1-, 10-, 100-, 150-, or 200-mg/kg body weight/day in the screening study (15 rats/group), and 50, 100, or 200 mg/kg/day in the definitive study (25 rats/group). In both studies, maternal food/water consumption, body weight, and clinical signs were monitored at regular intervals throughout gestation. At termination (gd 20, both studies), maternal liver and gravid uterine weights, number of ovarian corpora lutea, conceptus survival, fetal sex, and fetal body weight were evaluated. Fetal morphological examination included external structures (both studies) as well as visceral and skeletal structures (definitive study). In the screening study, maternal serum levels of 17β-estradiol, progesterone, prolactin, and luteinizing hormone were determined by radioimmunoassay, and mammary tissue was fixed, stained, and evaluated for percent glandular area within the fat pad. No maternal morbidity/mortality was found in either study. In the screening study, aversion to treatment (100 mg/kg/ day) and reduced maternal weight gain (150 mg/kg/day) were noted, but reproductive/endocrine parameters and fetal development were not affected. In the definitive study, aversion to treatment was noted at 2,-50 mg/kg/day, and mild sedation, reduced maternal food intake, and reduced body weight gain were found during initial treatment with 200 mg/kg/day. MEL had no effect on prenatal survival, fetal body weight, or incidences of fetal malformations/variations. Thus, in the definitive study, the maternal toxicity NOAEL and LOAEL were 100 and 200 mg/kg/day, respectively, and the developmental toxicity NOAEL was 200 mg/kg/day. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Toxicity testing
KW  - Melatonin
KW  - Sleep
KW  - Antioxidants
KW  - Luteinizing hormone
KW  - development
KW  - mammary gland
KW  - melatonin
KW  - pregnancy
KW  - prenatal toxicity
N1  - Accession Number: 44405799; Jahnke, G. 1; Email Address: Jahnke@NIEHS.NIH.gov; Marr, M. 2; Myers, C. 2; Wilson, R. 3; Travlos, G. 3; Price, C. 2; Affiliations: 1: Reproductive Toxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709; 3: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: Aug1999, Vol. 50 Issue 2, p271; Thesaurus Term: Toxicity testing; Subject Term: Melatonin; Subject Term: Sleep; Subject Term: Antioxidants; Subject Term: Luteinizing hormone; Author-Supplied Keyword: development; Author-Supplied Keyword: mammary gland; Author-Supplied Keyword: melatonin; Author-Supplied Keyword: pregnancy; Author-Supplied Keyword: prenatal toxicity; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Senderowicz, Adrian M.
AU  - Reid, Robert
AU  - Headlee, Donna
AU  - Abornathy, Troy
AU  - Horti, József
AU  - Lush, Richard M.
AU  - Reed, Eddie
AU  - Figg, William D.
AU  - Sausville, Edward A.
T1  - A Phase II Trial of Gallium Nitrate in Patients with Androgen-Metastatic Prostate Cancer.
JO  - Urologia Internationalis
JF  - Urologia Internationalis
Y1  - 1999/08//
VL  - 63
IS  - 2
M3  - Article
SP  - 120
EP  - 125
SN  - 00421138
AB  - Introduction: Due to in vitro data suggesting antitumor activity with gallium nitrate, we sought to evaluate the safety and activity in patients with androgen-independent prostate cancer. Method: Patients were eligible for this study if they had an ECOG performance status of ≤2, stage D2 metastatic prostate cancer that was progressing following combined androgen ablation (medical or surgical castration plus antiandrogen) and had failed antiandrogen withdrawal. Therapy consisted of gallium nitrate (200 mg/m[sup 2] /day) as a continuous infusion for 7 days, administered every 21 days, with hydration (100 ml/m[sup 2] /h). Individuals that had previously received suramin were treated at a dose of 150 mg/m[sup 2] /day of gallium nitrate. Results: Eight patients were enrolled: 4 patients at the 200 mg/m[sup 2] /day dose level and 4 patients at the lower dosage (150 mg/m[sup 2] /day). One of 8 patients had a >75% decline in prostate-specific antigen (PSA), 3 patients had stable PSA values for 17, 18 and 22 weeks, and 4 patients had progression by PSA (>50% increase over baseline). Anemia requiring transfusion occurred in 5 of 8 patients (63%). Two patients (25%) developed grade 4 toxicity: 1 patient developed complete blindness with partial reversal over 12 months, and another patient had pulmonary infiltrates, hypoxemia, and fever. Serious adverse events were not correlated to prior suramin exposure, or gallium plasma concentrations (total or free), but appeared to be related to cumulative cycles of gallium nitrate. Remaining adverse events were grade 1 or 2. No patients developed renal or neurological toxicity. Conclusion: This trial was prematurely terminated because repeated administration of gallium nitrate was poorly tolerated in an elderly population with androgen-independent prostate cancer. Gallium had modest clinical activity in this disease.Copyright © 1999 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB  - Copyright of Urologia Internationalis is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GALLIUM compounds
KW  - PROSTATE cancer
KW  - ANDROGENS
KW  - ANTINEOPLASTIC agents
KW  - TOXICOLOGY
KW  - Anemia
KW  - Atomic absorption spectrometry
KW  - Heavy metal
KW  - Hormone, refractory
KW  - Prostate-specific antigen
KW  - Vision loss
N1  - Accession Number: 11334692; Senderowicz, Adrian M. 1 Reid, Robert 1 Headlee, Donna 1 Abornathy, Troy 1 Horti, József 1 Lush, Richard M. 1 Reed, Eddie 1 Figg, William D. 1 Sausville, Edward A. 1; Affiliation:  1: Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA; Source Info: Aug99, Vol. 63 Issue 2, p120; Subject Term: GALLIUM compounds; Subject Term: PROSTATE cancer; Subject Term: ANDROGENS; Subject Term: ANTINEOPLASTIC agents; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Anemia; Author-Supplied Keyword: Atomic absorption spectrometry; Author-Supplied Keyword: Heavy metal; Author-Supplied Keyword: Hormone, refractory; Author-Supplied Keyword: Prostate-specific antigen; Author-Supplied Keyword: Vision loss; Number of Pages: 6p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3  - 10.1159/000030430
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11334692&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jeffrey Metter, Y.N.E.
AU  - Fleg, J.L.
T1  - Increased carotid artery intimal–medial thickness: risk factor for exercise-induced myocardial ischemia in asymptomatic older individuals.
JO  - Vascular Medicine
JF  - Vascular Medicine
Y1  - 1999/08//
VL  - 4
IS  - 3
M3  - Article
SP  - 181
EP  - 186
PB  - Sage Publications, Ltd.
SN  - 1358863X
AB  - Asymptomatic coronary artery disease (CAD) is prevalent in the general population and has been associated with an increased risk for symptomatic CAD. Although the diagnosis of asymptomatic CAD is currently dependent on exercise testing and coronary angiography, other vascular diagnostic techniques could potentially be of aid in the assessment. Increased intimal–medial thickness (IMT) of the common carotid artery as assessed by B-mode ultrason-ography is a purported index of atherosclerosis, and is associated with symptomatic CAD. Based on a recent report, this article will focus on the relationship between IMT and asymptomatic CAD as evidenced by exercise ECG, and in combination with exercise thallium scintigraphy. It was found that exercise-induced ST segment depression was associated with increased IMT independent of age, coronary risk factors and manifest CAD. After adjustment for age, IMT progressively increased from healthy subjects to asymptomatic subjects with positive exercise ECG alone, to those with concordant positive ECG and thallium scintigraphic findings who had IMT virtually identical to that in subjects with manifest CAD. Each 0.1 mm increase in IMT was associated with a 1.91-fold (95% CI 1.46–2.50) increased risk for concordant positive exercise tests or manifest CAD, independent of other coronary risk factors. These findings and the review of the literature suggest the potential utility of carotid ultrasonography in identifying asymptomatic individuals at higher risk for CAD. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Vascular Medicine is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CAROTID artery
KW  - CORONARY heart disease -- Risk factors
KW  - carotid arteries
KW  - coronary artery disease
KW  - exercise testing
KW  - risk factors
KW  - ultrasound
N1  - Accession Number: 4165687; Jeffrey Metter, Y.N.E. 1 Fleg, J.L. 1; Affiliation:  1: First Department of Medicine, Osaka University School of Medicine, Osaka, Japan and a Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Gerontology Research Center, Baltimore, MD, USA; Source Info: 1999, Vol. 4 Issue 3, p181; Subject Term: CAROTID artery; Subject Term: CORONARY heart disease -- Risk factors; Author-Supplied Keyword: carotid arteries; Author-Supplied Keyword: coronary artery disease; Author-Supplied Keyword: exercise testing; Author-Supplied Keyword: risk factors; Author-Supplied Keyword: ultrasound; Number of Pages: 6p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 1999-11322-002
AN  - 1999-11322-002
AU  - Wyatt, Richard J.
T1  - Soares & McGrath—the treatment of tardive dyskinesia: A systematic review and meta-analysis.
JF  - Schizophrenia Research
JO  - Schizophrenia Research
JA  - Schizophr Res
Y1  - 1999/08//
VL  - 39
IS  - 1
SP  - 17
EP  - 18
CY  - Netherlands
PB  - Elsevier Science
SN  - 0920-9964
N1  - Accession Number: 1999-11322-002. Partial author list: First Author & Affiliation: Wyatt, Richard J.; National Institute of Mental Health, Neuropsychiatry Branch, Bethesda, MD, US. Release Date: 20000101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Tardive Dyskinesia. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). Methodology: Meta Analysis. References Available: Y. Page Count: 2. Issue Publication Date: Aug, 1999. 
AB  - Comments on the review and meta-analysis of drug treatment for tardive dyskinesia by K. V. Soares and J. J. McGrath (see record [rid]1999-11322-001[/rid]). The author acknowledges this article for its introduction of important methods for performing future reviews, including a focus on studies using of randomized controlled trials and the use of meta-analytic techniques. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - drug treatment for tardive dyskinesia
KW  - commentary
KW  - 1999
KW  - Drug Therapy
KW  - Tardive Dyskinesia
KW  - 1999
DO  - 10.1016/S0920-9964(99)00022-5
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1999-11322-002&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2016-33197-016
AN  - 2016-33197-016
AU  - Grimaldi, Maurizio
AU  - Cavallaro, Sebastiano
T1  - Functional and molecular diversity of PACAP/VIP receptors in cortical neurons and type I astrocytes.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1999/08//
VL  - 11
IS  - 8
SP  - 2767
EP  - 2772
CY  - United Kingdom
PB  - Blackwell Publishing
SN  - 0953-816X
SN  - 1460-9568
AD  - Grimaldi, Maurizio, Laboratory of Adaptive Systems, NINDS, National Institutes of Health, Room 4 A22 BLDG. 36, 36 Convent Drive, Bethesda, MD, US, 20892
N1  - Accession Number: 2016-33197-016. PMID: 10457173 Partial author list: First Author & Affiliation: Grimaldi, Maurizio; Laboratory of Adaptive Systems, NINDS, National Institutes of Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20161003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cavallaro, Sebastiano. Major Descriptor: Neural Receptors; Neurons; Astrocytes; Molecular Neuroscience. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 6. Issue Publication Date: Aug, 1999. Publication History: Accepted Date: Mar 31, 1999; Revised Date: Mar 16, 1999; First Submitted Date: Jan 15, 1999. Copyright Statement: European Neuroscience Association. 1999. 
AB  - In the present study we determined the mRNA‐expression of pituitary adenylate cyclase activating polypeptide (PACAP)/vasoactive intestinal peptide (VIP) receptors in primary cultures of rat cortical neurons and type I astrocytes, and investigated the effects of PACAP38 on adenylyl cyclase, inositol phospholipid hydrolysis and intracellular calcium homeostasis. PACAP38 elicited a concentration‐dependent (1 nm–100 nm) increase in inositol phosphate levels and [Ca2+]i in neurons but not in type I astrocytes. The PACAP‐induced increase of intracellular calcium concentration, [Ca2+]i, was characterized by a spike, compatible with inositol trisphosphate (IP₃) ‐induced calcium mobilization from intracellular stores, and a plateau phase, sustained by activation of capacitative calcium entry triggered by depletion of IP₃‐sensitive calcium stores. In the absence of extracellular calcium, only the spike phase was present while the plateau phase was clearly reduced. In addition, thapsigargin pretreatment abolished the PACAP38‐induced [Ca2+]i rise. Treatment with 1 μm VIP did not affect [Ca2+]i in either neurons or type I astrocytes, clearly indicating the coupling of PAC1–HOP subtype to phospholipase‐C in neurons. In addition, as previously reported, PACAP38 stimulated cAMP formation in both neurons and type I astrocytes. Using the reverse transcription polymerase chain reaction, we found mRNA‐expression of PAC₁ (PACAP—HOP variant) and VPAC2 in neurons, PAC1 (PACAP—R variant), VPAC1 and VPAC₂ in astrocytes. These data indicate both a functional and molecular diversity of PACAP and VIP receptors in these cell types and support the view that the PAC1‐HOP variant may be responsible for phospholipase‐C activation and [Ca2+]i elevation in cortical neurons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - astrocyte
KW  - calcium
KW  - inositol phosphates
KW  - neuron
KW  - PACAP
KW  - VIP
KW  - 1999
KW  - Neural Receptors
KW  - Neurons
KW  - Astrocytes
KW  - Molecular Neuroscience
KW  - Rats
KW  - 1999
U1  - Sponsor: European Community, Europe. Grant: BIO4-CT98-0517. Recipients: Cavallaro, Sebastiano
DO  - 10.1046/j.1460-9568.1999.00693.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2016-33197-016&site=ehost-live&scope=site
UR  - ORCID: 0000-0001-7590-1792
UR  - ORCID: 0000-0002-7331-7055
UR  - maurizio@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43877-015
AN  - 2015-43877-015
AU  - Pivovarova, Natalia B.
AU  - Hongpaisan, Jarin
AU  - Andrews, S. Brian
AU  - Friel, David D.
T1  - Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: Spatial and temporal characteristics.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/08//
VL  - 19
IS  - 15
SP  - 6372
EP  - 6384
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Friel, David D., Department of Neuroscience, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, US, 44106
N1  - Accession Number: 2015-43877-015. PMID: 10414966 Partial author list: First Author & Affiliation: Pivovarova, Natalia B.; Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Calcium; Concentration; Depolarization; Mitochondria. Classification: Physiological Processes (2540). Population: Animal (20); Male (30). Methodology: Empirical Study; Mathematical Model; Quantitative Study. Page Count: 13. Issue Publication Date: Aug, 1999. Publication History: Accepted Date: May 17, 1999; Revised Date: Apr 20, 1999; First Submitted Date: Feb 2, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Several lines of evidence suggest that neuronal mitochondria accumulate calcium when the cytosolic free Ca2+ concentration ([Ca2+]i) is elevated to levels approaching ~500 nM, but the spatial, temporal, and quantitative characteristics of net mitochondrial Ca uptake during stimulus-evoked [Ca2+]i elevations are not well understood. Here, we report direct measurements of depolarization-induced changes in intramitochondrial total Ca concentration ([Ca]mito) obtained by x-ray microanalysis of rapidly frozen neurons from frog sympathetic ganglia. Unstimulated control cells exhibited undetectably low [Ca]mito, but high K+ depolarization (50 mM, 45 sec), which elevates [Ca2+]i to ~600 nM, increased [Ca]mito to 13.0 ± 1.5 mmol/kg dry weight; this increase was abolished by carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP). The elevation of [Ca]mito was a function of both depolarization strength and duration. After repolarization, [Ca]mito recovered to prestimulation levels with a time course that paralleled the decline in [Ca2+]i. Depolarization-induced increases in [Ca]mito were spatially heterogeneous. At the level of single mitochondria, [Ca]mito elevations depended on proximity to the plasma membrane, consistent with predictions of a diffusion model that considers radial [Ca2+]i gradients that exist early during depolarization. Within individual mitochondria, Ca was concentrated in small, discrete sites, possibly reflecting a high-capacity intramitochondrial Ca storage mechanism. These findings demonstrate that in situ Ca accumulation by mitochondria, now directly identified as the structural correlate of the 'FCCP-sensitive store, ' is robust, reversible, graded with stimulus strength and duration, and dependent on spatial location. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - mitochondria
KW  - calcium
KW  - calcium signaling
KW  - calcium regulation
KW  - neurons
KW  - depolarization
KW  - electron probe x-ray microanalysis
KW  - 1999
KW  - Calcium
KW  - Concentration
KW  - Depolarization
KW  - Mitochondria
KW  - 1999
U1  - Sponsor: American Heart Association, US. Grant: 96011490. Recipients: No recipient indicated
U1  - Sponsor: National Institutes of Health, Intramural Research Program, US. Recipients: No recipient indicated
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UR  - ddf2@po.cwru.edu
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43877-018
AN  - 2015-43877-018
AU  - Fuhrer, Christian
AU  - Gautam, Medha
AU  - Sugiyama, Janice E.
AU  - Hall, Zach W.
T1  - Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/08//
VL  - 19
IS  - 15
SP  - 6405
EP  - 6416
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Fuhrer, Christian, Brain Research Institute, University of Zurich-Irchel, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland
N1  - Accession Number: 2015-43877-018. PMID: 10414969 Partial author list: First Author & Affiliation: Fuhrer, Christian; Section on Synaptic Mechanisms, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Gautam, Medha. Major Descriptor: Acetylcholine; Cholinergic Receptors; Gap Junctions; Phosphorylation. Minor Descriptor: Membranes; Muscles; Proteins. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Aug, 1999. Publication History: Accepted Date: May 21, 1999; Revised Date: May 17, 1999; First Submitted Date: Feb 9, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - At the neuromuscular junction, aggregates of acetylcholine receptors (AChRs) are anchored in the muscle membrane by association with rapsyn and other postsynaptic proteins. We have investigated the interactions between the AChR and these proteins in cultured C2 myotubes before and after treatment with agrin, a nerve-derived protein that induces AChRs to cluster. When AChRs were isolated from detergent extracts of untreated C2 myotubes, they were associated with rapsyn and, to a lesser degree, with utrophin, β-dystroglycan, MuSK, and src-related kinases, but not with syntrophin. Treatment with agrin increased the association of AChRs with MuSK, a receptor tyrosine kinase that forms part of the agrin receptor complex, without affecting other interactions. Analysis of rapsyn-deficient myotubes, which do not form protein clusters in response to agrin, revealed that rapsyn is required for association of the AChR with utrophin and beta-dystroglycan, and for the agrin-induced increase in association with MuSK, but not for constitutive interactions with MuSK and src-related kinases. In rapsyn -/- myotubes, agrin caused normal tyrosine phosphorylation of AChR-associated and total MuSK, whereas phosphorylation of the AChR beta subunit, both constitutive and agrin-induced, was strongly reduced. These results show first that aneural myotubes contain preassembled AChR protein complexes that may function in the assembly of the postsynaptic apparatus, and second that rapsyn, in addition to its role in AChR phosphorylation, mediates selected protein interactions with the AChR and serves as a link between the AChR and the dystrophin/utrophin glycoprotein complex. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - synaptogenesis
KW  - acetylcholine receptor
KW  - agrin
KW  - rapsyn
KW  - neuromuscular junction
KW  - tyrosine phosphorylation
KW  - protein interactions
KW  - 1999
KW  - Acetylcholine
KW  - Cholinergic Receptors
KW  - Gap Junctions
KW  - Phosphorylation
KW  - Membranes
KW  - Muscles
KW  - Proteins
KW  - 1999
U1  - Sponsor: National Institute of Mental Health, US. Recipients: Gautam, Medha
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, US. Recipients: Sugiyama, Janice E.
U1  - Sponsor: National Institutes of Health, US. Recipients: Gautam, Medha
U1  - Sponsor: Swiss National Science Foundation, Switzerland. Other Details: Post-doctoral fellowship. Recipients: Fuhrer, Christian
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-43877-018&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43883-019
AN  - 2015-43883-019
AU  - Mammano, Fabio
AU  - Frolenkov, Gregory I.
AU  - Lagostena, Laura
AU  - Belyantseva, Inna A.
AU  - Kurc, Mauricio
AU  - Dodane, Valerie
AU  - Colavita, Alberto
AU  - Kachar, Bechara
T1  - ATP-induced Ca2+ release in cochlear outer hair cells: Localization of an inositol triphosphate-gated Ca2+ store to the base of the sensory hair bundle.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/08//
VL  - 19
IS  - 16
SP  - 6919
EP  - 6929
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Kachar, Bechara, Section on Structural Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 36, Room 5D-15, Bethesda, MD, US, 20892-4163
N1  - Accession Number: 2015-43883-019. Partial author list: First Author & Affiliation: Mammano, Fabio; Biophysics Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies, Trieste, Italy. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Mammano, Fabio. Major Descriptor: Calcium Ions; Cochlea; Evoked Potentials; Hair. Minor Descriptor: Pigs. Classification: Electrophysiology (2530). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Aug, 1999. Publication History: Accepted Date: Jun 1, 1999; Revised Date: May 21, 1999; First Submitted Date: Mar 3, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - We used a high-performance fluorescence imaging system to visualize rapid changes in intracellular free Ca2+ concentration ([Ca2+]i) evoked by focal applications of extracellular ATP to the hair bundle of outer hair cells (OHCs): the sensory–motor receptors of the cochlea. Simultaneous recordings of the whole-cell current and Calcium Green-1 fluorescence showed a two-component increase in [Ca2+]i. After an initial entry of Ca2+ through the apical membrane, a second and larger, inositol triphosphate (InsP₃)-gated, [Ca2+]i surge occurred at the base of the hair bundle. Electron microscopy of this intracellular Ca2+ release site showed that it coincides with the localization of a unique system of endoplasmic reticulum (ER) membranes and mitochondria known as Hensen’s body. Using confocal immunofluorescence microscopy, we showed that InsP₃ receptors share this location. Consistent with a Ca2+-mobilizing second messenger system linked to ATP-P2 receptors, we also determined that an isoform of G-proteins is present in the stereocilia. Voltage-driven cell shape changes and nonlinear capacitance were monitored before and after ATP application, showing that the ATP-evoked [Ca2+]i rise did not interfere with the OHC electromotility mechanism. This second messenger signaling mechanism bypasses the Ca2+-clearance power of the stereocilia and transiently elevates [Ca2+]i at the base of the hair bundle, where it can potentially modulate the action of unconventional myosin isozymes involved in maintaining the hair bundle integrity and potentially influence mechanotransduction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - sensory transduction
KW  - cochlea
KW  - purinergic receptors
KW  - InsP3
KW  - endoplasmic reticulum
KW  - mitochondria
KW  - G-proteins
KW  - electromotility
KW  - patch-clamp
KW  - calcium imaging
KW  - organ of Corti
KW  - Hensen’s body
KW  - 1999
KW  - Calcium Ions
KW  - Cochlea
KW  - Evoked Potentials
KW  - Hair
KW  - Pigs
KW  - 1999
U1  - Sponsor: Istituto Nazionale di Fisica della Materia Unit. Other Details: Piano di Ricerca Avanzata CADY. Recipients: Mammano, Fabio
U1  - Sponsor: International School for Advanced Studies, Abdus Salam Centre for Theoretical Physics. Other Details: Microelectronics for Fluorescence Imaging. Recipients: Colavita, Alberto; Mammano, Fabio
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UR  - kacharb@nidcd.nih.gov
UR  - mammano@sissa.it
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43883-020
AN  - 2015-43883-020
AU  - Dong, Hualing
AU  - Zhang, Peisu
AU  - Song, Insuk
AU  - Petralia, Ronald S.
AU  - Liao, Dezhi
AU  - Huganir, Richard L.
T1  - Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/08//
VL  - 19
IS  - 16
SP  - 6930
EP  - 6941
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Huganir, Richard L., Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, PCTB 904, Baltimore, MD, US, 21205
N1  - Accession Number: 2015-43883-020. PMID: 10436050 Partial author list: First Author & Affiliation: Dong, Hualing; Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, US. Release Date: 20160901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Glutamate Receptors; Proteins; AMPA. Minor Descriptor: Neural Receptors; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Aug, 1999. Publication History: Accepted Date: Jun 3, 1999; Revised Date: May 25, 1999; First Submitted Date: Mar 25, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - The molecular mechanisms underlying the targeting and localization of glutamate receptors at postsynaptic sites is poorly understood. Recently, we have identified a PDZ domain-containing protein, glutamate receptor-interacting protein 1 (GRIP1), which specifically binds to the C termini of AMPA receptor subunits and may be involved in the synaptic targeting of these receptors. Here, we report the cloning of GRIP2, a homolog of GRIP1, and the characterization of the GRIP1 and GRIP2 proteins in the rat CNS. GRIP1 and GRIP2 are ~130 kDa proteins that are highly enriched in brain. GRIP1 and GRIP2 are widely expressed in brain, with the highest levels found in the cerebral cortex, hippocampus, and olfactory bulb. Biochemical studies show that GRIP1 and GRIP2 are enriched in synaptic plasma membrane and postsynaptic density fractions. GRIP1 is expressed early in embryonic development before the expression of AMPA receptors and peaks in expression at postnatal day 8–10. In contrast, GRIP2 is expressed relatively late in development and parallels the expression of AMPA receptors. Immunohistochemistry using the GRIP1 antibodies demonstrated that GRIP1 is expressed in neurons in a somatodendritic staining pattern. At the ultrastructural level, DAB and immunogold electromicroscopy studies showed that GRIP1 was enriched in dendritic spines near the postsynaptic density and was expressed in dendritic shafts and in peri-Golgi regions in the neuronal soma. GRIP1 appeared to be clustered at both glutamatergic and GABAergic synapses. These results suggest that GRIP1 and GRIP2 are AMPA receptor binding proteins potentially involved in the targeting of AMPA receptors to synapses. GRIP1 also may play functional roles at both excitatory and inhibitory synapses, as well as in early neuronal development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - GRIP1
KW  - GRIP2
KW  - AMPA receptor
KW  - neuronal synapses
KW  - GAD
KW  - postsynaptic density
KW  - vesicle
KW  - development
KW  - 1999
KW  - Glutamate Receptors
KW  - Proteins
KW  - AMPA
KW  - Neural Receptors
KW  - Rats
KW  - 1999
U1  - Sponsor: Howard Hughes Medical Institute, US. Recipients: No recipient indicated
U1  - Sponsor: National Institutes of Health, National Institute of Neurological Disorders and Stroke, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Cassano, G. B.
AU  - Frank, E.
AU  - Maser, J. D.
AU  - Shear, M. K.
AU  - Rotondo, A.
AU  - Mauri, M.
AU  - Dell'Osso, L.
T1  - The panic-agoraphobic spectrum.
JO  - Human Psychopharmacology: Clinical & Experimental
JF  - Human Psychopharmacology: Clinical & Experimental
Y1  - 1999/08/02/Aug99 Supplement 1
VL  - 14
M3  - Article
SP  - S38
EP  - S44
PB  - John Wiley & Sons, Inc.
SN  - 08856222
AB  - Categorical classifications of mental disorders do not take into account the subthreshold, atypical and often enduring symptoms that accompany the core manifestations of full-blown mental disorders. However, this often neglected spectrum of symptoms may be as distressing and debilitating as the full-blown disorder and may have unrecognized importance in treatment selection and response. To this end, a spectrum approach to mental disorders, such as bipolar, obsessive-compulsive, eating, and panic disorder has been developed, which has been extensively used and proven effective in clinical practice. The need for a systematic identification and assessment of a broad array of symptoms and behavioural features led, as a first step, to the conceptualization of the panic-agoraphobic spectrum model and to the development of a structured interview (SCI-PAS). This model has been constructed by identifying different psychopathological and clinical domains incorporating and extending Panic Disorder as described in DSM-IV. The rationale, clinical usefulness, and heuristic significance of the panic-agoraphobic spectrum model will be discussed. Copyright © 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human Psychopharmacology: Clinical & Experimental is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AGORAPHOBIA
KW  - PANIC disorders
KW  - MENTAL illness
KW  - PATHOLOGICAL psychology
KW  - BIPOLAR disorder
KW  - agoraphobia
KW  - mental disorders
KW  - panic
N1  - Accession Number: 11822959; Cassano, G. B. 1 Frank, E. 2 Maser, J. D. 3 Shear, M. K. 2 Rotondo, A. 1 Mauri, M. 1 Dell'Osso, L. 1; Affiliation:  1: Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy  2: Western Psychiatric Institute and Clinic, University of Pittsburgh, PA, USA  3: Integrative Neuroscience of Schizophrenia, Mood and other Brain Disorders Program, National Institute of Mental Health, Rockville, MD, USA; Source Info: Aug99 Supplement 1, Vol. 14, pS38; Subject Term: AGORAPHOBIA; Subject Term: PANIC disorders; Subject Term: MENTAL illness; Subject Term: PATHOLOGICAL psychology; Subject Term: BIPOLAR disorder; Author-Supplied Keyword: agoraphobia; Author-Supplied Keyword: mental disorders; Author-Supplied Keyword: panic; Number of Pages: 1p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107080126
T1  - Foreword. Using feeding studies to test the efficacy of dietary interventions: lessons from the Dietary Approaches to Stop Hypertension trial.
AU  - Obarzanek E
AU  - Moore TJ
Y1  - 1999/08/02/Aug99 Supplement
N1  - Accession Number: 107080126. Language: English. Entry Date: 20000101. Revision Date: 20150819. Publication Type: Journal Article. Supplement Title: Aug99 Supplement. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Grants HL50968, HL50972, HL50977, HL50981, HL50982, HL02642, RR02635, and RR00722 from the National Heart, Lung, and Blood Institute (NHLBI), the Office of Research on Minority Health, and the National Center for Research Resources, National Institutes of Health, Bethesda, MD. NLM UID: 7503061. 
KW  - Research, Dietetics
KW  - Clinical Trials
KW  - Hypertension -- Diet Therapy
KW  - Diet
KW  - Blood Pressure
KW  - Funding Source
SP  - S9
EP  - 11
JO  - Journal of the American Dietetic Association
JF  - Journal of the American Dietetic Association
JA  - J AM DIET ASSOC
VL  - 99
CY  - New York, New York
PB  - Elsevier Science
SN  - 0002-8223
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Saeki, Toshiaki
AU  - Takashima, Shigemitsu
AU  - Tachibana, Mari
AU  - Koga, Masakazu
AU  - Hiyama, Eiso
AU  - Salomon, David S.
AU  - Holland, James F.
AU  - Ohnuma, Takao
T1  - Inhibitory Effect of Telomere-Mimic Phosphorothioate Oligodeoxy Nucleotides (S-ODNS) on Human Tumor Cell Lines.
JO  - Oncology
JF  - Oncology
Y1  - 1999/08/02/1999 Supplement 2
VL  - 57
M3  - Article
SP  - 27
EP  - 36
SN  - 00302414
AB  - To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5′-d(TTA GGG)n-3′] and examined their effects on the proliferation of human tumor cells by XTT assay. After 7 days of continuous exposure to 24T and 30T at concentrations ranging from 0.1 to 10 μM, concentration-dependent cell growth inhibition was observed in MCF-7 clone E3, ZR-75-1, MDA-MB 231, Colo 201 and WiDr. All of these cell lines highly expressed telomerase using the telomeric repeat amplification protocol. None of these tumor cell lines were affected by 18T. In MCF-7, ZR-75-1 and Colo 201 cell lines, a more than 50% growth inhibition was obtained by 3 μM of 24T and 30T whereas, in MDA-MB 231 and WiDr cell lines, cell growth inhibition was less than 50%. 30T was more effective than 24T. Estrogen-dependent growth of both MCF-7 and ZR-75-1 was inhibited by 3 μM of 24T and 30T, however, in the absence of estrogen, no growth inhibition was seen. The MCF-10A cell line, which was developed from normal human breast tissue and expressed telomerase only weakly, was inhibited by 10 μM of 18T. In conclusion, these observations indicate that S-ODNs inhibit tumor growth in cell lines expressing telomerase in a concentration-dependent manner and that cell growth inhibition is dependent on the length of S-ODNs. In addition, the short-length S-ODNs may inhibit growth of cells weakly expressing telomerase, but not of cells with high telomerase expression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - TELOMERASE
KW  - NUCLEOTIDES
KW  - COLON cancer
KW  - CANCER cells
KW  - CELL lines
KW  - Breast cancer
KW  - Colon cancer
KW  - Phosphorothioate oligodeoxy nucleotides
KW  - Telomerase
N1  - Accession Number: 11380410; Saeki, Toshiaki 1 Takashima, Shigemitsu 1 Tachibana, Mari 1 Koga, Masakazu 2 Hiyama, Eiso 3 Salomon, David S. 4 Holland, James F. 5 Ohnuma, Takao 5; Affiliation:  1: National Shikoku Cancer Center  2: Ehime University, Matsuyama  3: Hiroshima University, Hiroshima, Japan  4: National Cancer Institute, Bethesda, Md.  5: Mount Sinai School of Medicine, New York, N.Y., USA; Source Info: 1999 Supplement 2, Vol. 57, p27; Subject Term: TELOMERASE; Subject Term: NUCLEOTIDES; Subject Term: COLON cancer; Subject Term: CANCER cells; Subject Term: CELL lines; Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: Colon cancer; Author-Supplied Keyword: Phosphorothioate oligodeoxy nucleotides; Author-Supplied Keyword: Telomerase; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 1 Diagram, 1 Chart, 6 Graphs; Document Type: Article
L3  - 10.1159/000055272
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11380410&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mofenson, L. M.;
AU  - Lambert, J. S.;
AU  - Stiehm, E. R.;
AU  - Bethel, J.;
AU  - Nemo, G. J.;
AU  - \ET/;
T1  - Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine
CT  - Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine
JO  - New England Journal of Medicine (USA)
JF  - New England Journal of Medicine (USA)
Y1  - 1999/08/05/
VL  - 341
IS  - Aug 5
SP  - 385
EP  - 393
SN  - 00284793
AD  - Pediatr. Adolescent and Maternal AIDS Branch, Natl. Institute of Child Hlth. and Human Dev., 6100 Executive Blvd., Rm. 4B11, Rockville, MD 20852, USA Internet: lm65d@nih.gov
N1  - Accession Number: 36-13389; Language: English; Chemical Name: Zidovudine--30516-87-1; References: 43; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Elvira deC. Weiss
N2  - The effects of maternal, obstetrical, and infant-related characteristics and maternal virologic and immunologic variables on the risk of perinatal transmission of human immunodeficiency virus type 1 (HIV-1) were studied in 480 women and their infants who received zidovudine. Results showed that among pregnant women and their infants, all treated with zidovudine, the maternal plasma HIV-1 RNA level was the best predictor of the risk of perinatal transmission of HIV-1. Antiretroviral therapy that reduces the HIV-1 RNA level to below 500 copies/ml appears to minimize the risk of perinatal transmission as well as improve the health of the women.
KW  - Zidovudine--HIV infections-;
KW  - HIV infections--zidovudine--perinatal transmission;
KW  - Pediatrics--neonates--perinatal HIV transmission;
KW  - Antiretroviral agents--zidovudine--perinatal HIV transmission;
KW  - Pregnancy--zidovudine--perinatal HIV transmission;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107032464
T1  - Cholesterol lowering in the elderly population.
AU  - Grundy SM
AU  - Cleeman JI
AU  - Rifkind BM
AU  - Kuller LH
Y1  - 1999/08/09/
N1  - Accession Number: 107032464. Language: English. Entry Date: 20010622. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440. 
KW  - Hypercholesterolemia -- Therapy
KW  - Coronary Disease -- Prevention and Control
KW  - Hypercholesterolemia -- Diagnosis
KW  - Cardiovascular Risk Factors
KW  - Coronary Disease -- Drug Therapy
KW  - Antilipemic Agents -- Therapeutic Use
SP  - 1670
EP  - 1678
JO  - Archives of Internal Medicine
JF  - Archives of Internal Medicine
JA  - ARCH INTERN MED
VL  - 159
IS  - 15
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0003-9926
AD  - National Cholesterol Education Program (National Heart, Lung, and Blood Institute [NHLBI])
U2  - PMID: 10448768.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107032464&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Udey, Mark C.
AU  - Stanley, John R.
AU  - Udey, M C
AU  - Stanley, J R
T1  - Pemphigus--diseases of antidesmosomal autoimmunity.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/08/11/
VL  - 282
IS  - 6
M3  - journal article
SP  - 572
EP  - 576
SN  - 00987484
AB  - Discusses a group of autoantibody-mediated bullous diseases known as pemphigus.  Its being characterized by loss of keratinocyte cell-to-cell adhesion; Broader discussion of nonneoplastic cutaneous diseases; Their effect as significant causes of morbidity and mortality; Clinical and histologic features of pemphigus; Its pathophysiology; Therapy for pemphigus.
KW  - PEMPHIGUS
KW  - SKIN diseases
KW  - SKIN diseases -- Diagnosis
KW  - DIAGNOSIS
N1  - Accession Number: 2141955; Udey, Mark C. Stanley, John R. Udey, M C 1 Stanley, J R; Affiliation:  1: Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-1908, USA; Source Info: 8/11/99, Vol. 282 Issue 6, p572; Subject Term: PEMPHIGUS; Subject Term: SKIN diseases; Subject Term: SKIN diseases -- Diagnosis; Subject Term: DIAGNOSIS; Number of Pages: 5p; Illustrations: 6 Color Photographs, 2 Diagrams; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - Mofenson, L. M.;
T1  - Can perinatal HIV infection be eliminated in the United States?
CT  - Can perinatal HIV infection be eliminated in the United States?
JO  - Journal of the American Medical Association (USA)
JF  - Journal of the American Medical Association (USA)
Y1  - 1999/08/11/
VL  - 282
IS  - Aug 11
SP  - 577
EP  - 579
SN  - 00987484
AD  - Pediatric, Adolescent and Maternal AIDS Branch, Natl. Inst. of Child Hlth. and Human Development, NIH, 6100 Executive Blvd., Rm. 4B11, Rockville, MD 20852, USA Internet: lm65d@nih.gov
N1  - Accession Number: 36-14194; Language: English; Chemical Name: Zidovudine--30516-87-1; References: 31; Publication Type: Editorial; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Peggy L. Ruppel
N2  - A summary of recent research evaluating the efficacy of perinatal zidovudine prophylaxis of neonatal human immunodeficiency virus (HIV) infection is presented, and the results of studies that demonstrate the effectiveness of the treatment in clinical practice settings are discussed.
KW  - Zidovudine--HIV infections-;
KW  - HIV infections--zidovudine--pediatrics;
KW  - Pregnancy--zidovudine--HIV infection prophylaxis;
KW  - Drugs, clinical effectiveness--zidovudine--prophylaxis;
KW  - Pediatrics--neonates--zidovudine;
KW  - Antiretroviral agents--zidovudine--HIV infections prophylaxis;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Scidmore-Carlson, Marci A
AU  - Shaw, Edward I
AU  - Dooley, Cheryl A
AU  - Fischer, Elizabeth R
AU  - Hackstadt, Ted
T1  - Identification and characterization of a Chlamydia trachomatis early operon encoding four novel inclusion membrane proteins.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1999/08/15/
VL  - 33
IS  - 4
M3  - Article
SP  - 753
EP  - 765
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - Chlamydia trachomatis is a bacterial obligate intracellular parasite that replicates within a vacuole, termed an inclusion, that does not fuse with lysosomes. Within 2 h after internalization, the C. trachomatis inclusion ceases to interact with the endocytic pathway and, instead, becomes fusogenic with exocytic vesicles containing exogenously synthesized NBD-sphingomyelin. Both fusion of exocytic vesicles and long-term avoidance of lysosomal fusion require early chlamydial gene expression. Modification of the chlamydial inclusion probably occurs through the expression and insertion of chlamydial protein(s) into the inclusion membrane. To identify candidate inclusion membrane proteins, antisera were raised against a total membrane fraction purified from C. trachomatis -infected HeLa cells. By indirect immunofluorescence, this antisera recognized the inclusion membrane and, by immunoblot analysis, recognized three chlamydial-specific antigens of approximate molecular weights 15, 18 and 21 kDa. IncG , encoding an 18 kDa and 21 kDa doublet chlamydial antigen, was identified by screening a C. trachomatis , serovar L2, genomic expression library. Three additional genes, incD , incE and incF , were co-transcribed with incG . Monospecific antisera against each of the four genes of this operon demonstrated that the gene products were localized to the chlamydial inclusion membrane. Immediately downstream from the operon containing incD–G was the C. trachomatis homologue of incA . Like IncD, E, F and G, C. trachomatis IncA is also localized to the inclusion membrane. Reverse transcriptase–polymerase chain reaction (RT–PCR) analysis demonstrated that IncD–G , but not incA , are transcribed within the first 2 h after internalization, making them candidates for chlamydial factors required for the modification of the nascent chlamydial inclusion. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Chlamydia trachomatis
KW  - Membrane proteins
N1  - Accession Number: 5633157; Scidmore-Carlson, Marci A 1; Shaw, Edward I 1; Dooley, Cheryl A 1; Fischer, Elizabeth R 2; Hackstadt, Ted 1; Affiliations: 1: Host–Parasite Interactions Section, Laboratory of Intracellular Parasites,; 2: Microscopy Branch, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.; Issue Info: Aug99, Vol. 33 Issue 4, p753; Thesaurus Term: Chlamydia trachomatis; Subject Term: Membrane proteins; Number of Pages: 13p; Document Type: Article
L3  - 10.1046/j.1365-2958.1999.01523.x
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107225313
T1  - Cigarette smoking.
AU  - Bergen AW
AU  - Caporaso N
Y1  - 1999/08/18/
N1  - Accession Number: 107225313. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Cancer Genetics and Epidemiology Training Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services. NLM UID: 7503089. 
KW  - Smoking
KW  - Nicotine
KW  - Genetics
KW  - Personality
KW  - Socioeconomic Factors
KW  - Funding Source
SP  - 1365
EP  - 1375
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 16
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; e-mail: Bergena@epndce.nci.nih.gov
U2  - PMID: 10451441.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - DerSimonian, R.;
AU  - Levine, R. J.;
T1  - Resolving discrepancies between a meta-analysis and a subsequent large controlled trial
CT  - Resolving discrepancies between a meta-analysis and a subsequent large controlled trial
JO  - Journal of the American Medical Association (USA)
JF  - Journal of the American Medical Association (USA)
Y1  - 1999/08/18/
VL  - 282
IS  - Aug 18
SP  - 664
EP  - 670
SN  - 00987484
AD  - Natl. Inst. of Child Hlth. and Human Development, 6100 Executive Blvd., MSC7510, Bethesda, MD 20892-7510, USA Internet: dersimonian@nih.gov
N1  - Accession Number: 36-14443; Language: English; Chemical Name: Calcium--7440-70-2; Therapeutic Class: (88:00); AHFS Class: Dietary supplements calcium; References: 47; Publication Type: Review; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Methodology; Drug Evaluations; Abstract Author: Peggy L. Ruppel
N2  - A study evaluating the observed discrepancies between a meta-analysis and a large controlled study regarding the prophylactic effect of calcium supplementation in pre-eclampsia in pregnant women and to assess the role of effect heterogeneity in the discrepancies was conducted by reanalyzing 13 clinical studies evaluating the use of calcium to prevent pre-eclampsia. Substantial heterogeneity existed across trials. After stratifying studies by the presence of a placebo controlled group and by high-risk and low-risk populations, the conclusions of the meta-analysis of placebo-controlled trials enrolling a low-risk population were compatible with the conclusions of the large trial that calcium supplementation does not prevent pre-eclampsia in healthy nulliparous women. In contrast, the data implied a strong beneficial effect of calcium in healthy high-risk subject populations. However, only 225 women were analyzed, and, because of inconsistent data, these results remained equivocal.
KW  - Calcium--pre-eclampsia-;
KW  - Dietary supplements--calcium--pre-eclampsia;
KW  - Methodology--meta-analysis--pre-eclampsia;
KW  - Clinical studies--calcium--pre-eclampsia;
KW  - Pre-eclampsia--calcium--meta-analysis;
KW  - Pregnancy--calcium--pre-eclampsia;
KW  - Drugs, clinical effectiveness--calcium--pre-eclampsia;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107231547
T1  - Drug therapy: treatment of diabetic retinopathy.
AU  - Ferris FL III
AU  - Davis MD
AU  - Aiello LM
Y1  - 1999/08/26/
N1  - Accession Number: 107231547. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. 
KW  - Diabetic Retinopathy -- Therapy
KW  - Diabetic Retinopathy -- Prevention and Control
SP  - 667
EP  - 678
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 341
IS  - 9
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - National Eye Institute, National Institutes of Health, Bethesda, Md
U2  - PMID: 10460819.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107231547&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107227444
T1  - Transmission of drug-resistant strains of HIV-1: unfortunate, but inevitable.
AU  - Cohen OJ
AU  - Fauci AS
Y1  - 1999/08/28/
N1  - Accession Number: 107227444. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - HIV-1 -- Drug Effects
KW  - HIV Infections -- Transmission
KW  - Drug Resistance, Microbial
KW  - Antiviral Agents -- Therapeutic Use
KW  - HIV-1
KW  - HIV Infections -- Drug Therapy
SP  - 697
EP  - 698
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 354 North American Edition
IS  - 9180
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892
U2  - PMID: 10475176.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107127791
T1  - Functional imaging of craving.
AU  - Hommer DW
Y1  - 1999/09//
N1  - Accession Number: 107127791. Language: English. Entry Date: 20000801. Revision Date: 20151016. Publication Type: Journal Article; diagnostic images; glossary; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100900708. 
KW  - Brain -- Physiology
KW  - Behavior, Addictive
KW  - Tomography, Emission-Computed
KW  - Magnetic Resonance Imaging
KW  - Models, Theoretical
KW  - Alcoholism
KW  - Cocaine
KW  - Neuroanatomy
KW  - Substance Abusers
SP  - 187
EP  - 196
JO  - Alcohol Research & Health
JF  - Alcohol Research & Health
JA  - ALCOHOL RES HEALTH
VL  - 23
IS  - 3
CY  - Rockville, Maryland
PB  - National Institute on Alcohol Abuse & Alcoholism
AB  - To visualize brain activity associated with mental states, such as craving for alcohol and other drugs (AODs), researchers have begun to use functional imaging techniques. Three commonly used techniques are single photon emission computed tomography (SPECT), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI). Studies using these three approaches have been reviewed in order to evaluate the validity of a proposed model of the brain regions involved in alcoholism and the craving for alcohol. This model suggests a central role for a connected group of brain regions that include the basal ganglia, thalamus, and orbital cortex. A study using SPECT technology in alcoholics, however, found altered brain activity in only some of those regions during craving. Additional studies in alcoholics, as well as cocaine users, identified several other brain regions whose activities appeared to change in response to craving. These studies have led to the development of a revised model of brain regions involved in craving for AODs. Numerous questions remain, however, that must be answered before the brain areas involved in craving can be identified conclusively.
SN  - 1535-7414
AD  - Chief of the Section of Brain Electrophysiology and Imaging, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
U2  - PMID: 10890814.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107127791&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Keravich, D. P.;
AU  - Daniels, C. E.;
T1  - Challenges of thalidomide distribution in a hospital setting
CT  - Challenges of thalidomide distribution in a hospital setting
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
Y1  - 1999/09/01/
VL  - 56
IS  - Sep 1
SP  - 1721
EP  - 1725
SN  - 10792082
AD  - NIH, Warren G. Magnuson Clin. Ctr., Bldg. 10, Rm. 1N-257, Bethesda, MD 20892, USA Internet: cdaniels@nih.gov
N1  - Accession Number: 36-11705; Language: English; Trade Name: Thalomid; Generic Name: Thalidomide; Chemical Name: Thalidomide--50-35-1; Therapeutic Class: (8:00); AHFS Class: Anti-infective agents thalidomide; References: 2; Journal Coden: AHSPEK; Section Heading: Institutional Pharmacy Practice; Legislation, Laws and Regulations; Abstract Author: Peggy L. Ruppel
N2  - The development and implementation of hospital pharmacy policies and procedures intended to comply with the System for Thalidomide Education and Prescribing Safety (STEPS) program, which are intended to control and monitor prescribing and dispensing of thalidomide (Thalomid) for patients with moderate to severe erythema nodosum leprosum, are described and discussed; the STEPS program requires registration of patients, prescribing physicians, and dispensing pharmacies with a central database, and provides patient information and education materials. The STEPS program focuses on a retail pharmacy practice model, and does not reflect current hospital pharmacy practice. The program described adapted the program requirements to both inpatient and outpatient institutional practice.
KW  - Thalidomide--prescribing-;
KW  - Anti-infective agents--thalidomide--hospital pharmacy policies;
KW  - Administration--policies and procedures--hospital pharmacy;
KW  - Pharmacy, institutional, hospital--policies and procedures--thalidomide dispensing;
KW  - Regulations--thalidomide--hospital pharmacy policies;
KW  - Prescribing--physicians--thalidomide regulations;
KW  - Physicians--prescribing--thalidomide regulations;
KW  - Pharmacists, hospital--dispensing--thalidomide regulations;
KW  - Dispensing--pharmacists, hospital--thalidomide regulations;
KW  - Drug distribution systems--hospital pharmacy--thalidomide policies;
KW  - Patients--inpatients--thalidomide dispensing;
KW  - Patients--outpatients--thalidomide dispensing;
KW  - Erythema nodosum--thalidomide--hospital pharmacy policies;
KW  - Patient information--consultation--thalidomide;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107224147
T1  - Motor performance changes in children testing positive for HIV over 2 years.
AU  - Parks RA
AU  - Danoff JV
Y1  - 1999/09//Sep/Oct1999
N1  - Accession Number: 107224147. Language: English. Entry Date: 19991101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) (Bruininks). NLM UID: 7705978. 
KW  - Motor Skills -- Evaluation -- In Infancy and Childhood
KW  - HIV Infections -- Complications -- In Infancy and Childhood
KW  - Child Development Disorders -- Diagnosis
KW  - Pediatric Occupational Therapy
KW  - Prospective Studies
KW  - Time Series
KW  - Psychomotor Performance -- Evaluation -- In Infancy and Childhood
KW  - Clinical Assessment Tools
KW  - Research Instruments
KW  - Child
KW  - Male
KW  - Female
KW  - Human
SP  - 524
EP  - 528
JO  - American Journal of Occupational Therapy
JF  - American Journal of Occupational Therapy
JA  - AM J OCCUP THER
VL  - 53
IS  - 5
CY  - Bethesda, Maryland
PB  - American Occupational Therapy Association
AB  - OBJECTIVE: To determine the effect of HIV infection on the motor performance of children and preadolescents, the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) was administered to see whether performance scores (raw and standard) would change with duration of the disease. METHOD: Thirty-four children and preadolescents were tested on the BOTMP at initial diagnosis of HIV positive and again at 6-month intervals over a 2-year period for a total of five test sessions. The participants' scores on the Gross, Fine, and Battery Composites, as well as eight individual subtests, were compared with those of children who were developing typically. RESULTS: Gross Composite and Battery Composite percentile scores were consistently 1 to 2 standard deviations below the means for the normal reference populations over the 2-year period. Fine Composite scores were closer than +.5 standard deviation to the mean for the normal reference population. CONCLUSION: Gross motor function was more impaired than fine motor function in this sample of children and preadolescents who were HIV positive, and this pattern was unchanged after 2 years of infection. The BOTMP can be useful both to identify specific areas of motor deficits and to monitor changes in motor function over time after application of interventions.
SN  - 0272-9490
AD  - Occupational Therapy Section, Rehabilitation Medicine Department, National Institutes of Health, 10 Center Drive, MSC 1604, Bethesda, Maryland 20892-1604
U2  - PMID: 10500862.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Penninx, Brenda W. J. H.
AU  - Leveille, Suzanne
AU  - Ferrucci, Luigi
AU  - Van Eijk, Jacques Th. M.
AU  - Guralnik, Jack M.
T1  - Exploring the Effect of Depression on Physical Disability: Longitudinal Evidence From the Established Populations for Epidemiologic Studies of the Elderly.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/09//
VL  - 89
IS  - 9
M3  - Article
SP  - 1346
EP  - 1352
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study examined the effect of depression on the incidence of physical disability and the role of confounding and explanatory variables in this relationship. Methods. A cohort of 6247 subjects 65 years and older who were initially free of disability was followed up for 6 years. Baseline depression was assessed by the Center for Epidemiological Studies Depression Scale. Disability in mobility and disability in activities of daily living were measured annually. Results. Compared with the 5751 nondepressed subjects, the 496 depressed subjects had a relative risk (95% confidence interval) of 1.67 (1.44, 1.95) and 1.73 (1.54, 1.94) for incident disability in activities of daily living and mobility, respectively. Adjustment for sociodemographic characteristics and baseline chronic conditions reduced the risks to 1.39 (1.18, 1.63) and 1.45 (1.29, 1.93), respectively. Less physical activity and fewer social contacts among depressed persons further explained part of their increased disability risk. Conclusions. Depression in older persons may increase the risk for incident disability. This excess risk is partly explained by depressed persons' decreased physical activity and social interaction. The role of other factors (e.g., biological mechanisms) should be examined. (Am J Public Health. 1999;89:1346-1352) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL depression
KW  - AFFECTIVE disorders
KW  - DEPRESSED persons
KW  - SOCIAL contact
KW  - MENTALLY ill
KW  - EPIDEMIOLOGY
N1  - Accession Number: 2222985; Penninx, Brenda W. J. H. 1,2 Leveille, Suzanne 1 Ferrucci, Luigi 1,3 Van Eijk, Jacques Th. M. 4 Guralnik, Jack M. 1; Affiliation:  1: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Md  2: Institute for Research, Extramural Medicine, Free University, Amsterdam, The Netherlands  3: Geriatric Department, I Fraticini, National Research Institute, Florence, Italy  4: Institute for Research, Extramural Medicine, Free University, Amsterdam; Source Info: Sep99, Vol. 89 Issue 9, p1346; Subject Term: MENTAL depression; Subject Term: AFFECTIVE disorders; Subject Term: DEPRESSED persons; Subject Term: SOCIAL contact; Subject Term: MENTALLY ill; Subject Term: EPIDEMIOLOGY; Number of Pages: 7p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 6379
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107134118
T1  - Exploring the effect of depression on physical disability: longitudinal evidence from the established populations for epidemiologic studies of the elderly.
AU  - Penninx BWJ
AU  - Leveille S
AU  - Ferrucci L
AU  - van Eijk JTM
AU  - Guralnik JM
Y1  - 1999/09//
N1  - Accession Number: 107134118. Language: English. Entry Date: 20001001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D); Katz Index of Activities of Daily Living. Grant Information: Contracts N01-AG-0215, N01-AG-02106, and N01-AG-02107 from the National Institute on Aging (NIA). NLM UID: 1254074. 
KW  - Depression -- Complications -- In Old Age
KW  - Functional Status -- In Old Age
KW  - Secondary Analysis
KW  - Center for Epidemiological Studies Depression Scale
KW  - Prospective Studies
KW  - Geriatric Functional Assessment
KW  - Research Instruments
KW  - Cox Proportional Hazards Model
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Chi Square Test
KW  - Interviews
KW  - P-Value
KW  - Relative Risk
KW  - Confidence Intervals
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Funding Source
KW  - Human
SP  - 1346
EP  - 1352
JO  - American Journal of Public Health
JF  - American Journal of Public Health
JA  - AM J PUBLIC HEALTH
VL  - 89
IS  - 9
CY  - Washington, District of Columbia
PB  - American Public Health Association
AB  - OBJECTIVES: This study examined the effect of depression on the incidence of physical disability and the role of confounding and explanatory variables in this relationship. METHODS: A cohort of 6247 subjects 65 years and older who were initially free of disability was followed up for 6 years. Baseline depression was assessed by the Center for Epidemiological Studies Depression Scale. Disability in mobility and disability in activities of daily living were measured annually. RESULTS: Compared with the 5751 nondepressed subjects, the 496 depressed subjects had a relative risk (95% confidence interval) of 1.67 (1.44, 1.95) and 1.73 (1.54, 1.94) for incident disability in activities of daily living and mobility, respectively. Adjustment for sociodemographic characteristics and baseline chronic conditions reduced the risks to 1.39 (1.18, 1.63) and 1.45 (1.29, 1.93), respectively. Less physical activity and fewer social contacts among depressed persons further explained part of their increased disability risk. CONCLUSIONS: Depression in older persons may increase the risk for incident disability. This excess risk is partly explained by depressed persons' decreased physical activity and social interaction. The role of other factors (e.g., biological mechanisms) should be examined.
SN  - 0090-0036
AD  - Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave, Gateway Bldg, Suite 3C-309, Bethesda, MD 20892
U2  - PMID: 10474551.
DO  - 10.2105/AJPH.89.9.1346
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Piscitelli, S. C.;
AU  - Spooner, K.;
AU  - Baird, B.;
AU  - Chow, A. T.;
AU  - Walker, R. E.;
AU  - \ET/;
T1  - Pharmacokinetics and safety of high dose and extended interval regimens of levofloxacin in human immunodeficiency virus infected patients
CT  - Pharmacokinetics and safety of high dose and extended interval regimens of levofloxacin in human immunodeficiency virus infected patients
JO  - Antimicrobial Agents and Chemotherapy (USA)
JF  - Antimicrobial Agents and Chemotherapy (USA)
Y1  - 1999/09/01/
VL  - 43
IS  - Sep
SP  - 2323
EP  - 2327
SN  - 00664804
AD  - Bldg. 10, Rm. 11C103, NIH, 10 Center Dr. MSC 1880, Bethesda, MD 20892-1880, USA Internet: rwalker@nih.gov
N1  - Accession Number: 38-00689; Language: English; Chemical Name: Levofloxacin--138199-71-0 Levofloxacin--138199-71-0; References: 12; Journal Coden: AMACCQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Drug Metabolism and Body DistributionToxicity; Abstract Author: M. Therese Gyi
N2  - To study the pharmacokinetics and safety of high dose and extended interval levofloxacin in human immunodeficiency virus (HIV) infected patients, a randomized, double blind study was conducted in 30 patients (mean age 35.5 yr) who received 750 mg of levofloxacin or placebo once daily for 14 days, followed by 750 mg or 1000 mg of drug or placebo 3 times weekly for an additional 14 days. Levofloxacin disposition was characterized by rapid oral absorption, with peak concentrations occurring approximately 1.5 h after dosing and elimination half lives from 7.2 to 9.4 h. The overall incidence of any adverse effect was 70% (1000 mg) to 95% (750 mg) for levofloxacin treated patients and 71% for those taking placebo. Levofloxacin pharmacokinetic parameters for HIV infected patients were consistent with those observed in studies of healthy volunteers.
KW  - Levofloxacin--dosage schedules-;
KW  - Quinolones--levofloxacin--pharmacokinetics;
KW  - Dosage schedules--levofloxacin--pharmacokinetics;
KW  - HIV infections--levofloxacin--pharmacokinetics;
KW  - Pharmacokinetics--levofloxacin--dosage schedules;
KW  - Toxicity--levofloxacin--dosage schedules;
KW  - Half life--levofloxacin--dosage schedules;
KW  - Excretion--levofloxacin--dosage schedules;
KW  - Absorption--levofloxacin--HIV infections;
KW  - Blood levels--levofloxacin--dosage schedules;
KW  - Dosage--levofloxacin--pharmacokinetics;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 106928106
T1  - Defense and Veterans Head Injury Program (DVHIP): the William Fields Caveness Vietnam Head Injury Study -- past and future.
AU  - Grafman J
AU  - Salazar AM
Y1  - 1999///1999 Fall
N1  - Accession Number: 106928106. Language: English. Entry Date: 20020531. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; USA. NLM UID: 9810775. 
KW  - War -- Vietnam
KW  - Brain Injuries -- Rehabilitation
KW  - Research
KW  - Veterans
KW  - Vietnam
SP  - 12
EP  - 45
JO  - Brain Injury Source
JF  - Brain Injury Source
JA  - BRAIN INJ SOURCE
VL  - 3
IS  - 4
PB  - Brain Injury Association
SN  - 1094-3439
AD  - Chief, Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106928106&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kang, Min H.
AU  - Figg, William D.
AU  - Dahut, William
T1  - Taxanes in Hormone-Refractory Prostate Cancer.
JO  - Cancer Practice
JF  - Cancer Practice
Y1  - 1999/09//
VL  - 7
IS  - 5
M3  - Article
SP  - 270
EP  - 272
PB  - Wiley-Blackwell
SN  - 10654704
AB  - Examines the effectiveness of prostate cancer interventions.  Inhibition of growth and metastatic potential of prostrate cancer xenograft by paclitaxel; Rationale in combining estramustine and taxanes; Survival advantage of combination chemotherapy.
KW  - PROSTATE cancer -- Treatment
KW  - PACLITAXEL
N1  - Accession Number: 5303702; Kang, Min H. 1 Figg, William D. 2 Dahut, William 3; Affiliation:  1: Min H. Kang, PharmD, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  2: William D. Figg, PharmD, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.  3: William Dahut, MD, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Sep99, Vol. 7 Issue 5, p270; Subject Term: PROSTATE cancer -- Treatment; Subject Term: PACLITAXEL; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
L3  - 10.1046/j.1523-5394.1999.75005.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5303702&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107079614
T1  - Drug update. Taxanes in hormone-refractory prostate cancer.
AU  - Kang MH
AU  - Figg WD
AU  - Dahut W
A2  - Ignoffo RJ
Y1  - 1999/09//
N1  - Accession Number: 107079614. Language: English. Entry Date: 20000101. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; USA. Grant Information: U.S. Government. NLM UID: 9312355. 
KW  - Prostatic Neoplasms -- Drug Therapy
KW  - Paclitaxel -- Therapeutic Use
KW  - Docetaxel -- Therapeutic Use
KW  - Treatment Outcomes
KW  - Drug Therapy, Combination
KW  - Antineoplastic Agents, Alkylating -- Therapeutic Use
KW  - Male
KW  - Funding Source
SP  - 270
EP  - 272
JO  - Cancer Practice
JF  - Cancer Practice
JA  - CANCER PRACT
VL  - 7
IS  - 5
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 1065-4704
AD  - Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD
U2  - PMID: 10687598.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107079614&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107225608
T1  - What's your diagnosis?...tinea infection in a diabetic patient
AU  - Uwaifo GI
AU  - Rosen T
A2  - Schneiderman H
Y1  - 1999/09//
N1  - Accession Number: 107225608. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; case study; pictorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110. 
KW  - Tinea -- Diagnosis
KW  - Diabetic Patients
KW  - Aged
KW  - Male
SP  - 2541
EP  - 2545
JO  - Consultant (00107069)
JF  - Consultant (00107069)
JA  - CONSULTANT
VL  - 39
IS  - 9
CY  - Framingham, Massachusetts
PB  - United Business Media
SN  - 0010-7069
AD  - National Institutes of Health, Bethesda, Md
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107225608&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107225281
T1  - Molecular and genetic targets in early detection.
AU  - Henson DE
AU  - Srivastava S
AU  - Kramer BS
Y1  - 1999/09//1999 Sep
N1  - Accession Number: 107225281. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; bibliography. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007265. 
KW  - Neoplasms -- Prevention and Control
KW  - Neoplasms -- Familial and Genetic
KW  - Cancer Screening
KW  - Mutation
SP  - 419
EP  - 425
JO  - Current Opinion in Oncology
JF  - Current Opinion in Oncology
JA  - CURR OPIN ONCOL
VL  - 11
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
AB  - Recent research has revealed the existence of specific mutations in cancer. These mutations are being investigated as targets to find subjects at high risk for cancer, to detect early cancer, to detect the early recurrence of established cancer, and to find micrometastasis. These mutations are reviewed for the major anatomic sites. Some of the clinical issues related to the application of these mutations and the limitations of using molecular targets are also considered. Current methods for determining the risk of cancer are reviewed. Risk assessment is essential for defining cohorts for chemoprevention and other interventions. The concept of using surrogate anatomic and functional sites for estimating risk is introduced. Finally, the increasing complexity of molecular genetic analysis and the biologic heterogeneity of cancer are discussed in relation to early detection.
SN  - 1040-8746
AD  - Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892
U2  - PMID: 10505783.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107225281&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lund, Leif R.
AU  - Rømer, John
AU  - Bugge, Thomas H.
AU  - Nielsen, Boye S.
AU  - Frandsen, Thomas L.
AU  - Degen, Jay L.
AU  - Stephens, Ross W.
AU  - Danø, Keld
T1  - Functional overlap between two classes of matrix-degrading proteases in wound healing.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/09//9/1/99
VL  - 18
IS  - 17
M3  - Article
SP  - 4645
EP  - 4656
SN  - 02614189
AB  - Retarded wound healing was found in mice deficient in the serine protease precursor plasminogen, as well as in wild-type mice treated with the metalloprotease inhibitor galardin, but in both cases wound closure was ultimately completed in all mice within 60 days. The expression of several matrix metalloproteases in keratinocytes migrating to cover the wound was strongly enhanced by galardin treatment. However, when plasminogen-deficient mice were treated with galardin, healing was completely arrested and wound closure was not seen during an observation period of 100 days, demonstrating that protease activity is essential for skin wound healing. The requirement for both plasminogen deficiency and metalloprotease inhibition for complete inhibition of the healing process indicates that there is a functional overlap between the two classes of matrix-degrading proteases, probably in the dissection of the fibrin-rich provisional matrix by migrating keratinocytes. Each class alone is capable of maintaining sufficient keratinocyte migration to regenerate the epidermal surface, although this function would normally be performed by both classes acting in parallel. Since there are strong similarities between the proteolytic mechanisms in wound healing and cancer invasion, these results predict that complete arrest of this latter process in therapeutic settings will require the use of inhibitors of both classes of proteases. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MATRICES
KW  - AMINO acids
KW  - WOUND healing
KW  - PROTEOLYTIC enzymes
KW  - SERINE proteinases
KW  - PLASMINOGEN
KW  - METALLOPROTEINASES
KW  - keratinocytes
KW  - metalloprotease
KW  - plasminogen
KW  - serine protease
KW  - wound healing
N1  - Accession Number: 13004280; Lund, Leif R. 1 Rømer, John 1,2 Bugge, Thomas H. 3,4 Nielsen, Boye S. 1 Frandsen, Thomas L. 1 Degen, Jay L. 3 Stephens, Ross W. 1 Danø, Keld 1; Email Address: keld.dano@finsenlab.dk; Affiliation:  1: Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK-2100 Copenhagen ∅, Denmark  2: Histology, Health Care Discovery, Novo Nordisk, 2880 Bagsværd, Denmark  3: Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, OH 45229, USA  4: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 9/1/99, Vol. 18 Issue 17, p4645; Subject Term: MATRICES; Subject Term: AMINO acids; Subject Term: WOUND healing; Subject Term: PROTEOLYTIC enzymes; Subject Term: SERINE proteinases; Subject Term: PLASMINOGEN; Subject Term: METALLOPROTEINASES; Author-Supplied Keyword: keratinocytes; Author-Supplied Keyword: metalloprotease; Author-Supplied Keyword: plasminogen; Author-Supplied Keyword: serine protease; Author-Supplied Keyword: wound healing; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/18.17.4645
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004280&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Krause, B. J.
AU  - Horwitz, B.
AU  - Taylor, J. G.
AU  - Schmidt, D.
AU  - Mottaghy, F. M.
AU  - Herzog, H.
AU  - Halsband, U.
AU  - Müller-Gärtner, H. -W.
T1  - Network analysis in episodic encoding and retrieval of word-pair associates: a PET study.
JO  - European Journal of Neuroscience
JF  - European Journal of Neuroscience
Y1  - 1999/09//
VL  - 11
IS  - 9
M3  - Article
SP  - 3293
EP  - 3301
PB  - Wiley-Blackwell
SN  - 0953816X
AB  - Abstract The involvement of distributed brain regions in declarative memory has been hypothesized based on studies with verbal memory tasks. To characterize episodic declarative memory function further, 14 right-handed volunteers performed a visual verbal learning task using paired word associates. The volunteers underwent positron emission tomography. 15O-butanol was used as a tracer of regional cerebral blood flow (rCBF). Inter-regional functional interactions were assessed based on within-task, across-subject inter-regional rCBF correlations. Anatomical connections between brain areas were based on known anatomy. Structural equation modelling was used to calculate the path coefficients representing the magnitudes of the functional influences of each area on the ones to which it is connected by anatomical pathways. The encoding and the retrieval network elicit similarities in a general manner but also differences. Strong functional linkages involving visual integration areas, parahippocampal regions, left precuneus and cingulate gyrus were found in both encoding and retrieval; the functional linkages between posterior regions and prefrontal regions were more closely linked during encoding, whereas functional linkages between the left parahippocampal region and posterior cingulate as well as extrastriate areas and posterior cingulate gyrus were stronger during retrieval. In conclusion, these findings support the idea of a global bihemispheric, asymmetric encoding/retrieval network subserving episodic declarative memory. Our results further underline the role of the precuneus in episodic memory, not only during retrieval but also during encoding. [ABSTRACT FROM AUTHOR]
AB  - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - BRAIN function localization
KW  - MEMORY
KW  - episodic memory
KW  - network analysis
KW  - paired word associates
KW  - positron emission tomography
KW  - structural equation modelling
N1  - Accession Number: 5642938; Krause, B. J. 1,2 Horwitz, B. 3 Taylor, J. G. 4 Schmidt, D. 1,2 Mottaghy, F. M. 1,2 Herzog, H. 4 Halsband, U. 5 Müller-Gärtner, H. -W. 1,2; Affiliation:  1: Department of Nuclear Medicine, Heinrich-Heine-University Hospital, Moorenstrasse 5, 40225 Düsseldorf, Germany  2: Department of Nuclear Medicine (KME), Research Centre Jülich, 52425 Jülich, Germany  3: Laboratory of Neuroscience, National Institute on Ageing, National Institutes of Health, Bethesda, MD, USA  4: Institute of Medicine (IME), Research Centre Jülich, 52425 Jülich, Germany  5: Institute for Medical Psychology and Behavioural Neurobiology, Eberhard-Karls-University, 72074 Tübingen, Germany; Source Info: Sep99, Vol. 11 Issue 9, p3293; Subject Term: BRAIN function localization; Subject Term: MEMORY; Author-Supplied Keyword: episodic memory; Author-Supplied Keyword: network analysis; Author-Supplied Keyword: paired word associates; Author-Supplied Keyword: positron emission tomography; Author-Supplied Keyword: structural equation modelling; Number of Pages: 9p; Illustrations: 4 Diagrams, 4 Charts; Document Type: Article
L3  - 10.1046/j.1460-9568.1999.00723.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5642938&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107078660
T1  - Intended pregnancies and unintended pregnancies: distinct categories or opposite ends of a continuum?...the findings of Trussell, Vaughan and Stanford
AU  - Bachrach CA
AU  - Newcomer S
Y1  - 1999/09//Sep/Oct99
N1  - Accession Number: 107078660. Language: English. Entry Date: 20070101. Revision Date: 20150820. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0241370. 
KW  - Pregnancy, Unplanned
KW  - Family Planning
KW  - Pregnancy
KW  - Female
SP  - 251
EP  - 252
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
JA  - FAM PLANN PERSPECT
VL  - 31
IS  - 5
CY  - New York, New York
PB  - Guttmacher Institute, Inc.
SN  - 0014-7354
AD  - Chief, Demographic and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Washington, DC
U2  - PMID: 10723654.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107078660&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107230339
T1  - Issues in respiratory care. Nursing challenge: caring for a patient with complex, multiple complications.
AU  - Peterson AB
AU  - Hall T
Y1  - 1999/09//1999 Sep-Oct
N1  - Accession Number: 107230339. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0330057. 
KW  - Wegener's Granulomatosis -- Nursing
KW  - Wegener's Granulomatosis -- Complications
KW  - Postoperative Complications -- Nursing
KW  - Clinical Exemplars
KW  - Bandages and Dressings
KW  - Pneumonectomy -- Adverse Effects
KW  - Nurse-Patient Relations
KW  - Respiratory Nursing
KW  - Adult
KW  - Male
SP  - 373
EP  - 376
JO  - Heart & Lung
JF  - Heart & Lung
JA  - HEART LUNG
VL  - 28
IS  - 5
CY  - New York, New York
PB  - Elsevier Science
SN  - 0147-9563
AD  - Nursing Department, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 10486455.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107230339&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Nyska, A.
AU  - Maronpot, R.R.
AU  - Ghanayem, B.I.
T1  - Ocular thrombosis and retinal degeneration induced in female F344 rats by 2-butoxyethanol.
JO  - Human & Experimental Toxicology
JF  - Human & Experimental Toxicology
Y1  - 1999/09//
VL  - 18
IS  - 9
M3  - Article
SP  - 577
EP  - 582
PB  - Sage Publications, Ltd.
SN  - 09603271
AB  - 2-butoxyethanol, used extensively for domestic and industrial purposes, was tested in our experiments for its potential to cause damage to female rat ocular tissues. Female rats were previously found to be particularly sensitive to 2-butoxyethanol. A group of eight female F344 rats (2 – 3 months old) were exposed by gavage to 250 mg of 2-butoxyethanol/kg b.w. per day for 3 consecutive days and sacrificed 24 h after the last dose. Eight female rats received the dosing vehicle (water) and served as controls. At necropsy, petechial hemorrhages were noted on the sclera. Microscopic examination revealed treatment-related effects in the eyes, in addition to other known effects of BE exposure such as disseminated thrombosis and necrosis and infarction in various organs. The spectrum of histopathological changes noted in the eyes included hemorrhages localized in the posterior layers of the retina, leading to photoreceptor degeneration. Thrombi were identified in ciliary processes and limbal blood vessels. Histological changes suggestive of the retinal ischemic-infarctive process were also noted. Possible pathogenic mechanisms of 2-butoxyethanol-induced retinopathy are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Human & Experimental Toxicology is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DISEASES
KW  - Thrombosis
KW  - Retinal degeneration
KW  - Eye
KW  - Ethylene glycol monobutyl ether
KW  - rat
KW  - retina
KW  - thrombosis
N1  - Accession Number: 4672594; Nyska, A. 1; Maronpot, R.R. 1; Ghanayem, B.I. 1; Affiliations: 1: National Institute of Environmental Health Sciences (NIEHS), National Institute of Health, PO Box 12233, Research Triangle Park, North Carolina, NC 27709, USA; Issue Info: 1999, Vol. 18 Issue 9, p577; Thesaurus Term: DISEASES; Subject Term: Thrombosis; Subject Term: Retinal degeneration; Subject Term: Eye; Author-Supplied Keyword: Ethylene glycol monobutyl ether; Author-Supplied Keyword: rat; Author-Supplied Keyword: retina; Author-Supplied Keyword: thrombosis; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 107114716
T1  - School physical education: secondary analyses of the School Health Policies and Programs Study.
AU  - Simons-Morton B
AU  - Eitel P
AU  - Small ML
Y1  - 1999/09//1999 Sep-Oct
N1  - Accession Number: 107114716. Language: English. Entry Date: 20000501. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137. 
KW  - School Health Services
KW  - Physical Education and Training
KW  - Sports
KW  - Exercise
KW  - Surveys
KW  - Schools, Middle
KW  - Schools, Secondary
KW  - Questionnaires
KW  - Interviews
KW  - Teachers
KW  - Organizational Compliance
KW  - Data Analysis Software
KW  - Confidence Intervals
KW  - Adolescence
KW  - United States
KW  - Human
SP  - S21
EP  - 7
JO  - Journal of Health Education
JF  - Journal of Health Education
JA  - J HEALTH EDUC
VL  - 30
IS  - 5
CY  - Reston, Virginia
PB  - American Alliance for Health, Physical Education, Recreation & Dance
AB  - General interest in promoting physical activity amongyoungpeople is increasing. School physical education provides an opportunity for students to develop the skills they need to engage in lifelong physical activities. The School Health Policies and Programs Study (SHPPS), conducted in 1994 by the Centers for Disease Control and Prevention, provides an in-depth description of multiple components of the school health program at the state, district, school, and classroom levels nationwide. In this article we examine data from the physical education component of SHPPS to help answer the following questions: (1) What physical activities are most frequently taught in physical education and what proportion of these are lifetime physical activities? (2) How much physical education is required in middle/junior high and senior high schools? (3) What policies and practices are associated with the amount of physical education required? Team sports are among the most frequently taught activities in physical education. However, the amount of physical education required in middle/junior and senior high schools is not adequate and falls short of the national health objective. Supportive state, district, and school policies, and joint activities between physical education and health services are associated with increased amounts of required physical education.
SN  - 1055-6699
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Mailstop K-33, 4770 Buford Highway, NE, Atlanta, GA; e-mail: Bruce_SimonsMorton@NIH.GOV
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - LeBlanc, Rona A.
AU  - Pesnicak, Lesley
AU  - Godleski, Matthew
AU  - Straus, Stephen E.
AU  - LeBlanc, R A
AU  - Pesnicak, L
AU  - Godleski, M
AU  - Straus, S E
T1  - The comparative effects of famciclovir and valacyclovir on herpes simplex virus type 1 infection, latency, and reactivation in mice.
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
Y1  - 1999/09//9/1/99
VL  - 180
IS  - 3
M3  - journal article
SP  - 594
EP  - 599
SN  - 00221899
AB  - Infections by herpes simplex virus (HSV) cannot yet be eliminated, but the severity of the disease can be reduced. Two newer drugs with established efficacy for such infections, famciclovir and valacyclovir, were tested in a mouse eye model of HSV infection. Both drugs significantly reduced mortality and titers of virus shed from the eyes of mice infected with an otherwise lethal dose of HSV type 1 (HSV-1). Similar titers of HSV-1 were found in the eyes, ganglia, and brains of treated animals. Although valacyclovir reduced the latent viral DNA load better in these studies than did famciclovir, rates of reactivation by explantation and UV exposure were the same. Thus, in this study, famciclovir and valacyclovir were equally effective in limiting the virulence and spread of HSV-1, despite their biochemical and pharmacologic differences. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Antiviral agents
KW  - Virus diseases
KW  - Herpes simplex virus
N1  - Accession Number: 5253059; LeBlanc, Rona A.; Pesnicak, Lesley; Godleski, Matthew; Straus, Stephen E.; LeBlanc, R A 1; Pesnicak, L; Godleski, M; Straus, S E; Affiliations: 1: Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland 20892-1888, USA; Issue Info: 9/1/99, Vol. 180 Issue 3, p594; Thesaurus Term: Antiviral agents; Thesaurus Term: Virus diseases; Subject Term: Herpes simplex virus; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: journal article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 5253059
T1  - The comparative effects of famciclovir and valacyclovir on herpes simplex virus type 1 infection, latency, and reactivation in mice.
AU  - LeBlanc, Rona A.
AU  - Pesnicak, Lesley
AU  - Godleski, Matthew
AU  - Straus, Stephen E.
AU  - LeBlanc, R A
AU  - Pesnicak, L
AU  - Godleski, M
AU  - Straus, S E
Y1  - 1999/09//9/1/99
N1  - Accession Number: 5253059. Language: English. Entry Date: 20010309. Revision Date: 20161127. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675. 
KW  - Herpesviruses -- Drug Effects
KW  - Antiviral Agents -- Pharmacodynamics
KW  - Prodrugs -- Pharmacodynamics
KW  - Purines -- Analogs and Derivatives
KW  - Herpes Simplex -- Drug Therapy
KW  - Valine
KW  - Microbiologic Phenomena -- Drug Effects
KW  - Viral Physiology -- Drug Effects
KW  - Acyclovir -- Analogs and Derivatives
KW  - Acyclovir -- Therapeutic Use
KW  - Herpesviruses
KW  - Brain
KW  - Antiviral Agents -- Therapeutic Use
KW  - Mice
KW  - Herpesviruses -- Physiology
KW  - Prodrugs -- Therapeutic Use
KW  - Primates
KW  - Female
KW  - Valine -- Pharmacodynamics
KW  - Ganglia, Sensory
KW  - Valine -- Therapeutic Use
KW  - Eye
KW  - Purines -- Pharmacodynamics
KW  - Acyclovir -- Pharmacodynamics
KW  - Animal Studies
KW  - Purines -- Therapeutic Use
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
SP  - 594
EP  - 599
JO  - Journal of Infectious Diseases
JF  - Journal of Infectious Diseases
JA  - J INFECT DIS
VL  - 180
IS  - 3
PB  - Oxford University Press / USA
AB  - Infections by herpes simplex virus (HSV) cannot yet be eliminated, but the severity of the disease can be reduced. Two newer drugs with established efficacy for such infections, famciclovir and valacyclovir, were tested in a mouse eye model of HSV infection. Both drugs significantly reduced mortality and titers of virus shed from the eyes of mice infected with an otherwise lethal dose of HSV type 1 (HSV-1). Similar titers of HSV-1 were found in the eyes, ganglia, and brains of treated animals. Although valacyclovir reduced the latent viral DNA load better in these studies than did famciclovir, rates of reactivation by explantation and UV exposure were the same. Thus, in this study, famciclovir and valacyclovir were equally effective in limiting the virulence and spread of HSV-1, despite their biochemical and pharmacologic differences.
SN  - 0022-1899
AD  - Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland 20892-1888, USA
U2  - PMID: 10438344.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=5253059&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Kadidal, V. V.
AU  - Mayo, D. J.
AU  - Horne, M. K.
T1  - Heparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three cases.
JO  - Journal of Internal Medicine
JF  - Journal of Internal Medicine
Y1  - 1999/09//
VL  - 246
IS  - 3
M3  - Article
SP  - 325
EP  - 329
PB  - Wiley-Blackwell
SN  - 09546820
AB  - Abstract. Kadidal VV, Mayo DJ, Horne MK (National Institutes of Health, Bethesda, MD 20892, USA) Heparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three cases (Case Report). J Intern Med 1999; 246: 325–329. Three cases of heparin-induced thrombocytopenia (HIT) are reported that were provoked by daily heparin flushes of central venous access devices. Each case had confounding features that delayed recognition of the problem. A review of the literature revealed only 29 previously reported cases of HIT secondary to heparin flushes. However, the true incidence of this problem is unknown. A high index of suspicion and confirmatory laboratory tests are necessary to make the diagnosis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Internal Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THROMBOCYTOPENIA
KW  - HEPARIN
KW  - PHYSIOLOGY
KW  - RISK factors
KW  - heparin
KW  - thrombocytopenia
N1  - Accession Number: 5183699; Kadidal, V. V. 1 Mayo, D. J. 1 Horne, M. K. 1; Affiliation:  1: From the Hematology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Sep99, Vol. 246 Issue 3, p325; Subject Term: THROMBOCYTOPENIA; Subject Term: HEPARIN; Subject Term: PHYSIOLOGY; Subject Term: RISK factors; Author-Supplied Keyword: heparin; Author-Supplied Keyword: thrombocytopenia; Number of Pages: 5p; Document Type: Article
L3  - 10.1046/j.1365-2796.1999.00527.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5183699&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Malinda, Katherine M.
AU  - Sidhu, Gurmel S.
AU  - Mani, Haresh
AU  - Banaudha, Krishna
AU  - Maheshwari, Radha K.
AU  - Goldstein, Allan L.
AU  - Kleinman, Hynda K.
T1  - Thymosin β4 Accelerates Wound Healing.
JO  - Journal of Investigative Dermatology
JF  - Journal of Investigative Dermatology
Y1  - 1999/09//
VL  - 113
IS  - 3
M3  - Article
SP  - 364
EP  - 368
SN  - 0022202X
AB  - Angiogenesis is an essential step in the repair process that occurs after injury. In this study, we investigated whether the angiogenic thymic peptide thymosin β4 (Tβ4) enhanced wound healing in a rat full thickness wound model. Addition of Tβ4 topically or intraperitoneally increased reepithelialization by 42% over saline controls at 4 d and by as much as 61% at 7 d post-wounding. Treated wounds also contracted at least 11% more than controls by day 7. Increased collagen deposition and angiogenesis were observed in the treated wounds. We also found that Tβ4 stimulated keratinocyte migration in the Boyden chamber assay. After 4–5 h, migration was stimulated 2–3-fold over migration with medium alone when as little as 10 pg of Tβ4 was added to the assay. These results suggest that Tβ4 is a potent wound healing factor with multiple activities that may be useful in the clinic. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THYMOSIN
KW  - WOUND healing
KW  - RATS as laboratory animals
KW  - angiogenesis
KW  - migrations
KW  - reepithelialization
KW  - thymic peptides
N1  - Accession Number: 5167333; Malinda, Katherine M. 1 Sidhu, Gurmel S. 2 Mani, Haresh 2 Banaudha, Krishna 2 Maheshwari, Radha K. 2 Goldstein, Allan L. 3 Kleinman, Hynda K. 1; Affiliation:  1: Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, U.S.A.;  2: Center for Combat Casualty and Life Sustainment Research, Department of Pathology, USUHS, Bethesda, Maryland, U.S.A.;  3: Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, U.S.A.; Source Info: Sep99, Vol. 113 Issue 3, p364; Subject Term: THYMOSIN; Subject Term: WOUND healing; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: angiogenesis; Author-Supplied Keyword: migrations; Author-Supplied Keyword: reepithelialization; Author-Supplied Keyword: thymic peptides; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Illustrations: 12 Black and White Photographs, 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3  - 10.1046/j.1523-1747.1999.00708.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5167333&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Gray, Alex M.
AU  - Rawls, Scott M.
AU  - Shippenberg, Toni S.
AU  - McGinty, Jacqueline F.
T1  - The K-Opioid Agonist, U-69593, Decreases Acute Amphetamine-Evoked Behaviors and Calcium-Dependent Dialysate Levels of Dopamine and Glutamate in the Ventral Striatum.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/09//
VL  - 73
IS  - 3
M3  - Article
SP  - 1066
EP  - 1074
PB  - Wiley-Blackwell
SN  - 00223042
AB  - The effect of a k-opioid receptor agonist on acute amphetamine-induced behavioral activation and dialysate levels of dopamine and glutamate in the ventral striatum were investigated. Amphetamine (2.5 mg/kg i.p.) evoked a substantial increase in rearing, sniffing, and hole-poking behavior as well as dopamine and glutamate levels in the ventral striatum of awake rats. U-69593 (0.32 mg/kg s.c.) significantly decreased the amphetamine-evoked increase in behavior and dopamine and glutamate levels in the ventral striatum. Reverse dialysis of the selective k-opioid receptor antagonist, nor-binaltorphimine, into the ventral striatum antagonized the effects of U-69593 on amphetamine-induced behavior and dopamine and glutamate levels. Reverse dialysis of low calcium (0.1 mM) into the ventral striatum decreased basal dopamine, but not glutamate, dialysate levels by 91% 45 min after initiation of perfusion. Strikingly, 0.1 mM calcium perfusion significantly reduced the 2.5 mg/kg amphetamine-evoked increase in dopamine and glutamate levels in the ventral striatum, distinguishing a calcium-dependent and a calcium-independent component of release. U-69593 did not alter the calcium-independent component of amphetamine-evoked dopamine and glutamate levels. These data are consistent with the view that a transsynaptic mechanism augments the increase in dopamine and glutamate levels in the ventral striatum evoked by a moderately high dose of amphetamine and that stimulation of k-opioid receptors suppresses the calcium-dependent component of amphetamine’s effects. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OPIOIDS
KW  - BRAIN microdialysis
KW  - DOPAMINE
KW  - Dopamine
KW  - Glutamate
KW  - k-Opioid receptors
KW  - Microdialysis
KW  - Opioid receptors
KW  - Ventral striatum
N1  - Accession Number: 6797811; Gray, Alex M. Rawls, Scott M. Shippenberg, Toni S. 1 McGinty, Jacqueline F.; Affiliation:  1: Integrative Neuroscience Unit, Brain Imaging Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, U.S.A.; Source Info: Sep99, Vol. 73 Issue 3, p1066; Subject Term: OPIOIDS; Subject Term: BRAIN microdialysis; Subject Term: DOPAMINE; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Glutamate; Author-Supplied Keyword: k-Opioid receptors; Author-Supplied Keyword: Microdialysis; Author-Supplied Keyword: Opioid receptors; Author-Supplied Keyword: Ventral striatum; Number of Pages: 9p; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0731066.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=6797811&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sihver, Wiebke
AU  - Fasth, Karl-Johan
AU  - Horti, Andrew G.
AU  - Koren, Andrei O.
AU  - Bergström, Mats
AU  - Lu, Li
AU  - Hagberg, Gisela
AU  - Lundqvist, Hans
AU  - Dannals, Robert F.
AU  - London, Edythe D.
AU  - Nordberg, Agneta
AU  - Långström, Bengt
T1  - Synthesis and Characterization of Binding of 5-[76Br] Bromo-3-[[2(S)-Azetidinyl]methoxy]pyridine, a Novel Nicotinic Acetylcholine Receptor Ligand, in Rat Brain.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/09//
VL  - 73
IS  - 3
M3  - Article
SP  - 1264
EP  - 1272
PB  - Wiley-Blackwell
SN  - 00223042
AB  - 5-[76Br]Bromo-3-[[2(S)-azetidinyl]methoxy]-pyridine ([76Br]BAP), a novel nicotinic acetylcholine receptor ligand, was synthesized using [76Br]bromide in an oxidative bromodestannylation of the corresponding trimethylstannyl compound. The radiochemical yield was 25%, and the specific radioactivity was on the order of 1 Ci/μmol. The binding properties of [76Br]BAP were characterized in vitro and in vivo in rat brain, and positron emission tomography (PET) experiments were performed in two rhesus monkeys. In association experiments on membranes of the cortex and thalamus, >90% of maximal specific [76Br]BAP binding was obtained after 60 min. The dissociation half-life of [76Br]BAP was 51 ± 6 min in cortical membranes and 56 ± 3 min in thalamic membranes. Saturation experiments with [76Br]BAP revealed one population of binding sites with dissociation constant (KD) values of 36 ± 9 and 30 ± 9 pM in membranes of cortex and thalamus, respectively. The maximal binding site density (Bmax) values were 90 ± 17 and 207 ± 33 fmol/mg in membranes of cortex and thalamus, respectively. Scatchard plots were nonlinear, and the Hill coefficients were <1, suggesting the presence of a lower-affinity binding site. In vitro autoradiography studies showed that binding of [76Br]BAP was high in the thalamus and presubiculum, moderate in the cortex and striatum, and low in the cerebellum and hippocampus. A similar pattern of [76Br]BAP accumulation was observed by ex vivo autoradiography. In vivo, binding of [76Br]BAP in whole rat brain was blocked by preinjection of (S)(-)-nicotine (0.3 mg/kg) by 27, 52, 68, and 91% at survival times of 10, 25, 40, 120, and 300 min, respectively. In a preliminary PET study in rhesus monkeys, the highest [76Br]BAP uptake was found in the thalamus, and radioactivity was displaceable by ~60% with cytisine and by 50% with (S)(-)-nicotine. The data of this study indicate that [76Br]BAP is a promising radioligand for the characterization of nicotinic acetylcholine receptors in vivo. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NICOTINIC receptors
KW  - NEUROTRANSMITTER receptors
KW  - EMISSION tomography
KW  - 5-[
KW  - In vitro studies
KW  - In vivo studies
KW  - Nicotinic receptor binding
KW  - Positron emission tomography
N1  - Accession Number: 6797787; Sihver, Wiebke 1,2 Fasth, Karl-Johan 1 Horti, Andrew G. 3 Koren, Andrei O. 3 Bergström, Mats 1 Lu, Li 1 Hagberg, Gisela 1 Lundqvist, Hans 4 Dannals, Robert F. 3 London, Edythe D. 3 Nordberg, Agneta 5 Långström, Bengt 1; Affiliation:  1: PET Centre Uppsala University Uppsala U.S.A.  2: Department of Medical Pharmacology, Uppsala University, Uppsala, U.S.A.  3: Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Division of Molecular Neuropharmacology, Huddinge Hospital, Huddinge, Sweden, U.S.A.  4: Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, U.S.A.  5: Department of Oncology, Radiology, and Clinical Immunology, Division of Biomedical Radiation Sciences, Uppsala University, Uppsala; Source Info: Sep99, Vol. 73 Issue 3, p1264; Subject Term: NICOTINIC receptors; Subject Term: NEUROTRANSMITTER receptors; Subject Term: EMISSION tomography; Author-Supplied Keyword: 5-[; Author-Supplied Keyword: In vitro studies; Author-Supplied Keyword: In vivo studies; Author-Supplied Keyword: Nicotinic receptor binding; Author-Supplied Keyword: Positron emission tomography; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 9p; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0731264.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=6797787&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107104497
T1  - Announcing the biotechnology century.
AU  - Slavkin HC
Y1  - 1999/09//
N1  - Accession Number: 107104497. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; glossary; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Biotechnology -- Trends
KW  - Genetics
KW  - Abnormalities -- Familial and Genetic
KW  - Hereditary Diseases
KW  - Mouth Diseases -- Familial and Genetic
KW  - Information Resources
SP  - 1374
EP  - 1378
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 9
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, Md 20892-2290
U2  - PMID: 10492546.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107104497&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107231106
T1  - Patient education. Ultrasound, magnetic resonance imaging, and computed tomography.
AU  - Dow OK
Y1  - 1999/09//1999 Sep-Oct
N1  - Accession Number: 107231106. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Ultrasonography
KW  - Magnetic Resonance Imaging
KW  - Tomography, X-Ray Computed
KW  - Patient Education
SP  - 493
EP  - 497
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 5
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Clinical Center/Diagnostic Radiology Department, National Institutes of Health, Bethesda, MD
U2  - PMID: 10795216.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107231106&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107223632
T1  - Perceptual determinants of Pap test up-to-date status among minority women [corrected] [published erratum appears in ONCOL NURS FORUM 1999 Nov-Dec; 26(10): 1587].
AU  - Jennings-Dozier K
Y1  - 1999/09//1999 Sep
N1  - Accession Number: 107223632. Language: English. Entry Date: 19991101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Behavioral Belief Scale; Pap Smear Questionnaire (PSQ); Normative Belief Scale; Control Belief Scale. Grant Information: Supported by the Institutional National Research Service Award Grant #T32 NR07036, the University of Pennsylvania William Fontaine Doctoral Fellowship Award, and the ONS Foundation Ethnic Minority Researcher and Mentorship Grant. NLM UID: 7809033. 
KW  - Cervical Smears
KW  - Minority Groups -- Pennsylvania
KW  - Blacks -- Pennsylvania
KW  - Hispanics -- Pennsylvania
KW  - Cancer Screening
KW  - Health Beliefs
KW  - Funding Source
KW  - Descriptive Research
KW  - Correlational Studies
KW  - Pennsylvania
KW  - Ajzen-Fishbein Theory of Reasoned Action
KW  - Conceptual Framework
KW  - Health Beliefs -- Evaluation
KW  - Convenience Sample
KW  - Attitude Measures
KW  - Descriptive Statistics
KW  - Discriminant Analysis
KW  - Female
KW  - Human
SP  - 1327
EP  - 1333
JO  - Oncology Nursing Forum
JF  - Oncology Nursing Forum
JA  - ONCOL NURS FORUM
VL  - 26
IS  - 8
CY  - Pittsburgh, Pennsylvania
PB  - Oncology Nursing Society
AB  - PURPOSE/OBJECTIVES: To determine whether African American and Latina women were up-to-date on getting an annual Pap test and whether behavioral, normative, and control beliefs differed among women who were up-to-date versus women who were not. DESIGN: Descriptive, correlational. SETTING: Urban, community-based agencies located within the Philadelphia metropolitan area. SAMPLE: 204 African American and Latina women. METHODS: Data were collected using an investigator-developed questionnaire to measure behavioral, normative, and control beliefs, and a demographic assessment survey was used to measure up-to-date status. FINDINGS: African American women who were up-to-date on annual Pap tests were more likely to report behavioral beliefs about the characteristics and actions of the physician and were less concerned about the Pap test experience. They were more likely to report normative beliefs concerning the approval of their parents, friends, doctor, family, and mother. African American women also were more likely to report control beliefs concerning choice of a doctor and having access to screening and free screening. The women who were up-to-date were less concerned about needing information or reminders regarding annual screening than those who were not up-to-date. Latina women who were up-to-date on annual Pap tests were more likely to report behavioral beliefs about the benefits of Pap tests and were less concerned about the Pap test experience. They were more likely to report normative beliefs concerning the approval of their mother, doctor, parents, spouse/significant other, and friends. Latinas also were more likely to report control beliefs concerning the need for family assistance, have access to screening, receive reminders, and have a female doctor than those who were not up-to-date. IMPLICATIONS FOR NURSING PRACTICE: Differences within and between ethnic groups justify the need for culturally specific interventions and patient education geared toward promoting regular Pap test screening.
SN  - 0190-535X
AD  - National Cancer Institute, Rockville, MD
U2  - PMID: 10497772.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107223632&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 104718118
T1  - An international survey of cancer pain characteristics and syndromes. IASP Task Force on Cancer Pain. International Association for the Study of Pain.
AU  - Caraceni, A
AU  - Portenoy, R K
Y1  - 1999/09//1999 Sep
N1  - Accession Number: 104718118. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Brief Pain Inventory (BPI). NLM UID: 7508686. 
KW  - Surveys
KW  - International Relations
KW  - Neoplasms -- Complications
KW  - Pain Measurement
KW  - Cross Sectional Studies
KW  - Female
KW  - Human
KW  - Male
KW  - Middle Age
KW  - Questionnaires
KW  - Syndrome
KW  - Brief Pain Inventory
SP  - 263
EP  - 274
JO  - Pain (03043959)
JF  - Pain (03043959)
JA  - PAIN
VL  - 82
IS  - 3
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0304-3959
AD  - Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy. carceni@istitutotumori.mi.it
U2  - PMID: 10488677.
DO  - 10.1016/S0304-3959(99)00073-1
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107225354
T1  - Bilateral prophylactic mastectomy decision making: a vignette study.
AU  - Stefanek M
AU  - Enger C
AU  - Benkendorf J
AU  - Honig SF
AU  - Lerman C
Y1  - 1999/09//1999 Sep
N1  - Accession Number: 107225354. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0322116. 
KW  - Mastectomy -- Psychosocial Factors
KW  - Decision Making, Patient
KW  - Breast Neoplasms -- Familial and Genetic
KW  - Vignettes
KW  - P-Value
KW  - Questionnaires
KW  - Risk Assessment
KW  - Univariate Statistics
KW  - Logistic Regression
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - 216
EP  - 221
JO  - Preventive Medicine
JF  - Preventive Medicine
JA  - PREV MED
VL  - 29
IS  - 3
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
AB  - Background. Little is known about the perception of bilateral prophylactic mastectomy (BPM), and whether perceptions are influenced by a family history of breast cancer. It is also unclear what factors may play a role in selecting BPM for follow-up care. Methods. Samples of predominantly Caucasian, well-educated women with (n = 129) and without (n = 104) family histories of breast cancer were provided a vignette of a woman at increased risk. They selected one of two follow-up options: (1) clinical breast examination, breast self exam, and annual mammography or (2) BPM. Results. The samples did not differ on the decision to select BPM (29.5% vs 22.1%). The family history sample reported worry about breast cancer as a problem (34.4%) more often than women with no history (15.7%). Multivariate analysis found worry and estimated 10-year risk of the woman in the vignette as significant predictors of selecting BPM. Conclusions. Approximately 25% of our sample selected BPM as the preferred option. The majority supported the need to discuss BPM among women at increased risk. Finally, both factors associated with the selection of BPM (worry, risk assessment) are potentially amenable to psychosocial or educational approaches. There is a clear need for assessment of worry and risk perception prior to surgical decision making. Copyright 1999 American Health Foundation and Academic Press.
SN  - 0091-7435
AD  - Behavioral Research Program, Division of Cancer Control and Population Services, National Cancer Institute, 6130 Executive Blvd/EPN 211, Bethesda, MD 20892; e-mail: ms496r@nih.gov
U2  - PMID: 10479610.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107225354&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107090210
T1  - Future directions in cancer rehabilitation.
AU  - Gerber LH
Y1  - 1999/09//
N1  - Accession Number: 107090210. Language: English. Entry Date: 20000201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA. 
KW  - Rehabilitation, Cancer -- Trends
KW  - Functional Status
KW  - Survival
KW  - Risk Factors
KW  - Cancer Pain -- Therapy
KW  - Fatigue -- Therapy
KW  - Therapeutic Exercise
SP  - 15
EP  - 16
JO  - Rehabilitation Oncology
JF  - Rehabilitation Oncology
JA  - REHABIL ONCOL
VL  - 17
IS  - 3
CY  - Alexandria, Virginia
PB  - American Physical Therapy Association, Oncology Section
SN  - 2168-3808
AD  - Chief, Rehabilitation Medicine Department, Warren G. Magnusen Clinical Center, National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - GEN
AU  - Publicker, Stephanie
AU  - Stoklosa, Kristin
T1  - Reaching the researcher: How the national institutes of health library selects and provides e-journals via the world wide web
JO  - Serials Review
JF  - Serials Review
Y1  - 1999///
VL  - 25
IS  - 3
M3  - Article
SP  - 13
PB  - Elsevier Science Publishing Company, Inc.
SN  - 00987913
AB  - The National Institutes of Health Library created a set of criteria to facilitate decision-making for the selection of electronic journals. Criteria include patterns for use of printed counterparts, frequency of update to current issues, and the availability of cross-platform access. The Library gives highest priority to Web-based journals with licenses that allow multi-user access outside the limits of the library walls. The Library's Electronic Resources Team monitors publisher Websites and relevant listservs for announcements of online availability of journals in the collection. The team then evaluates and recommends the acquisition of electronic journals that are made accessible to users through a passworded area of the Library's homepage. Discusses criteria used to select high-use journals that will be of greatest interest to the largest number of NIH researchers. Also discusses IP access and the problem of passwords, increasing user expectations for instant access, and how the Library promotes the use of e-journals.
KW  - ELECTRONIC publications
KW  - RESEARCH libraries
KW  - COLLECTION management (Libraries)
KW  - INTERNET
KW  - ELECTRONIC journals
KW  - LIBRARY resources
KW  - UNITED States. -- National Institutes of Health
N1  - Accession Number: 2676668; Publicker, Stephanie 1; Stoklosa, Kristin 2; Affiliations: 1 : National Library of Medicine, Bethesda, MD 20894; 2 : National Institutes of Health, Bethesda, MD 20892;  Source Info: 1999, Vol. 25 Issue 3, p13; Note: Publisher: Elsevier Science Publishing Company, Inc.; Note: Update Code: 3501; Subject Term: ELECTRONIC publications; Subject Term: RESEARCH libraries; Subject Term: COLLECTION management (Libraries); Subject Term: INTERNET; Subject Term: ELECTRONIC journals; Subject Term: LIBRARY resources; Subject Term: UNITED States. -- National Institutes of Health; Number of Pages: 11p; Illustrations: 1 chart, 3 diagrams; Document Type: Article
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DP  - EBSCOhost
DB  - lih
ER  - 

TY  - JOUR
AU  - Williams, Judith K.
AU  - Boykin, Fred
T1  - The Role of Social Work in HIV/AIDS Clinical Trials.
JO  - Social Work in Health Care
JF  - Social Work in Health Care
Y1  - 1999/09//
VL  - 29
IS  - 1
M3  - Article
SP  - 35
EP  - 56
SN  - 00981389
AB  - The social worker can facilitate screening, retention and patient adherence in HIV/AIDS clinical trials. This paper introduces the process and its key vocabulary, and uses three case studies to demonstrate how social workers can assist clients who may wish to participate in, or are already enrolled in a clinical trial. After examining five major issues that affect the client in a clinical trial (informed consent; treatment vs. research; risks and side effects; altruism; the role of family members; and gender, race and class issues), the authors elaborate on interventions at the screening level, and concrete services and psycho social interventions for study participants. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Social Work in Health Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL workers
KW  - CLINICAL trials
KW  - AIDS (Disease)
KW  - OPERANT behavior
KW  - PSYCHOSOCIAL factors
KW  - adherence
KW  - clinical trials
KW  - compliance
KW  - HIV/AIDS
KW  - retention
KW  - screening
KW  - social work
N1  - Accession Number: 2178830; Williams, Judith K. 1; Email Address: jwilliams@nih.gov Boykin, Fred 2; Email Address: fboykin@nih.gov; Affiliation:  1: Coordinator of the HIV Counseling Program, Clinical Center, National Institutes of Health, Building 10, Room 1N252, 9000 Rockville Pike, Bethesda, MD  20892  2: Senior Clinical Social Worker, Clinical Center, National Institutes of Health, Building 10, Room 1N252, 9000 Rockville Pike, Bethesda, MD  20892; Source Info: 1999, Vol. 29 Issue 1, p35; Subject Term: SOCIAL workers; Subject Term: CLINICAL trials; Subject Term: AIDS (Disease); Subject Term: OPERANT behavior; Subject Term: PSYCHOSOCIAL factors; Author-Supplied Keyword: adherence; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: compliance; Author-Supplied Keyword: HIV/AIDS; Author-Supplied Keyword: retention; Author-Supplied Keyword: screening; Author-Supplied Keyword: social work; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 22p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107209961
T1  - The role of social work in HIV/AIDS clinical trials.
AU  - Williams JK
AU  - Boykin F
Y1  - 1999/09//
N1  - Accession Number: 107209961. Language: English. Entry Date: 19990901. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7603729. 
KW  - Social Work
KW  - Clinical Trials
KW  - HIV Infections
KW  - Research Subject Retention
KW  - Research Ethics
KW  - Professional Role
KW  - Patient Compliance
KW  - Health Care Delivery
KW  - Insurance, Disability
KW  - Research Methodology
KW  - Support, Psychosocial
KW  - Case Management
KW  - Male
KW  - Female
SP  - 35
EP  - 56
JO  - Social Work in Health Care
JF  - Social Work in Health Care
JA  - SOC WORK HEALTH CARE
VL  - 29
IS  - 1
CY  - Oxfordshire, <Blank>
PB  - Routledge
AB  - The social worker can facilitate screening, retention and patient adherence in HIV/AIDS clinical trials. This paper introduces the process and its key vocabulary, and uses three case studies to demonstrate how social workers can assist clients who may wish to participate in, or are already enrolled in a clinical trial. After examining five major issues that affect the client in a clinical trial (informed consent; treatment vs. research; risks and side effects; altruism; the role of family members; and gender, race and class issues), the authors elaborate on interventions at the screening level, and concrete services and psychosocial interventions for study participants.
SN  - 0098-1389
AD  - Coordinator, HIV Counseling Program, Clinical Center, National Institutes of Health, Building 10, Room 1N252, 9000 Rockville Pike, Bethesda, MD 20892; e-mail: jwilliams@nih.gov
U2  - PMID: 10482128.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107225284
T1  - Granulocyte storage and antigen stability.
AU  - Chun H
AU  - Cipolone K
AU  - Procter J
AU  - Stroncek DF
Y1  - 1999/09//
N1  - Accession Number: 107225284. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360. 
KW  - Blood Preservation
KW  - Granulocytes -- Analysis
KW  - Immunoassay
KW  - Technology, Medical -- Methods
KW  - Antigens
KW  - Flow Cytometry
KW  - Staining and Labeling
KW  - Isoantibodies -- Analysis
KW  - Human
SP  - 983
EP  - 990
JO  - Transfusion
JF  - Transfusion
JA  - TRANSFUSION
VL  - 39
IS  - 9
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0041-1132
AD  - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C711, 10 Center Drive MSC1184, Bethesda, MD 20892-1184. E-mail: hchun@dtm.cc.nih.gov
U2  - PMID: 10533825.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 2015-44014-031
AN  - 2015-44014-031
AU  - Wenner, Peter
AU  - O'Donovan, Michael J.
T1  - Identification of an interneuronal population that mediates recurrent inhibition of motoneurons in the developing chick spinal cord.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/09//
VL  - 19
IS  - 17
SP  - 7557
EP  - 7567
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Wenner, Peter, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A50, Bethesda, MD, US, 20892-4455
N1  - Accession Number: 2015-44014-031. PMID: 10460262 Partial author list: First Author & Affiliation: Wenner, Peter; Section on Developmental Neurobiology, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160901. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Motor Neurons; Spinal Cord; Interneurons. Minor Descriptor: Chickens; Synaptic Plasticity. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Sep, 1999. Publication History: Accepted Date: Jun 23, 1999; Revised Date: Jun 14, 1999; First Submitted Date: May 6, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Studies on the development of synaptic specificity, embryonic activity, and neuronal specification in the spinal cord have all been limited by the absence of a functionally identified interneuron class (defined by its unique set of connections). Here, we identify an interneuron population in the embryonic chick spinal cord that appears to be the avian equivalent of the mammalian Renshaw cell (R-interneurons). These cells receive monosynaptic nicotinic, cholinergic input from motoneuron recurrent collaterals. They make predominately GABAergic connections back onto motoneurons and to other R-interneurons but project rarely to other spinal interneurons. The similarity between the connections of the developing R-interneuron, shortly after circuit formation, and the mature mammalian Renshaw cell raises the possibility that R-interneuronal connections are formed precisely from the onset. Using a newly developed optical approach, we identified the location of R-interneurons in a column, dorsomedial to the motor nucleus. Functional characterization of the R-interneuron population provides the basis for analyses that have so far only been possible for motoneurons. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - spinal interneuron
KW  - Renshaw cell
KW  - spontaneous activity
KW  - imaging
KW  - synaptic specificity
KW  - spinal cord
KW  - chick embryo
KW  - 1999
KW  - Motor Neurons
KW  - Spinal Cord
KW  - Interneurons
KW  - Chickens
KW  - Synaptic Plasticity
KW  - 1999
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, Intramural Research Program, US. Recipients: No recipient indicated
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-44056-008
AN  - 2015-44056-008
AU  - Tomić, Melanija
AU  - Zivadinovic, Dragoslava
AU  - Van Goor, Fredrick
AU  - Yuan, Davy
AU  - Koshimizu, Taka-aki
AU  - Stojilkovic, Stanko S.
T1  - Expression of Ca2+-mobilizing endothelinA receptors and their role in the control of Ca2+ influx and growth hormone secretion in pituitary somatotrophs.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/09//
VL  - 19
IS  - 18
SP  - 7721
EP  - 7731
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Stojilkovic, Stanko S., Section on Cellular Signaling, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Building 49, Room 6A-36, 49 Convent Drive, Bethesda, MD, US, 20892-4510
N1  - Accession Number: 2015-44056-008. PMID: 10479676 Partial author list: First Author & Affiliation: Tomić, Melanija; Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160822. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Somatotropin; Action Potentials; Ghrelin; Adenylyl Cyclase. Minor Descriptor: Rats. Classification: Electrophysiology (2530). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Sep, 1999. Publication History: Accepted Date: Jun 30, 1999; Revised Date: Jun 29, 1999; First Submitted Date: May 19, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - The expression and coupling of endothelin (ET) receptors were studied in rat pituitary somatotrophs. These cells exhibited periods of spontaneous action potential firing that generated high-amplitude fluctuations in cytosolic calcium concentration ([Ca2+]i). The message and the specific binding sites for ETA, but not ETB, receptors were found in mixed pituitary cells and in highly purified somatotrophs. The activation of these receptors by ET-1 led to an increase in inositol 1,4,5-trisphosphate production and the associated rise in [Ca2+]i and growth hormone (GH) secretion. The Ca2+-mobilizing action of ET-1 lasted for 2-3 min and was followed by an inhibition of action potential-driven Ca2+ influx and GH secretion to below the basal levels. As in somatostatin-treated cells, the ET-1-induced inhibition of spontaneous electrical activity and Ca2+ influx was accompanied by the inhibition of adenylyl cyclase and by the stimulation of inward rectifier potassium current. In contrast to somatostatin, ET-1 did not inhibit voltage-gated Ca2+ channels. During prolonged agonist stimulation a gradual recovery of Ca2+ influx and GH secretion occurred. In somatotrophs treated with pertussis toxin overnight, the ET-1-induced Ca2+-mobilizing phase was preserved, but it was followed immediately by facilitated Ca2+ influx and GH secretion. Both somatostatin- and ET-1-induced inhibitions of adenylyl cyclase activity were abolished in pertussis toxin-treated cells. These results indicate that the transient cross-coupling of Ca2+-mobilizing ETA receptors to the Gi/Go pathway in somatotrophs provides an effective mechanism to change the rhythm of [Ca2+]i signaling and GH secretion during continuous agonist stimulation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - somatotrophs
KW  - growth hormone
KW  - calcium
KW  - endothelin
KW  - somatostatin
KW  - electrical activity
KW  - 1999
KW  - Somatotropin
KW  - Action Potentials
KW  - Ghrelin
KW  - Adenylyl Cyclase
KW  - Rats
KW  - 1999
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DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - CHAP
AU  - Leshner, Alan I.
AU  - Schroeder, Steven A.
T1  - Introduction.
JO  - Nicotine & Tobacco Research
JF  - Nicotine & Tobacco Research
Y1  - 1999/09/02/Sep1999 Supplement
VL  - 1
M3  - Book Chapter
SP  - S9
EP  - S9
SN  - 14622203
AB  - Presents an introductory statement to the September 1999 issue of "Nicotine & Tobacco Research.
KW  - NICOTINE
KW  - PERIODICALS
N1  - Accession Number: 18755405; Leshner, Alan I. 1 Schroeder, Steven A. 2; Affiliation:  1: Director, National Institute on Drug Abuse  2: President, The Robert Wood Johnson Foundation; Source Info: Sep1999 Supplement, Vol. 1, pS9; Subject Term: NICOTINE; Subject Term: PERIODICALS; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; Number of Pages: 1p; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - CHAP
AU  - Turkkan, Jaylan
AU  - Condon, Timothy
T1  - Introduction.
JO  - Nicotine & Tobacco Research
JF  - Nicotine & Tobacco Research
Y1  - 1999/09/02/Sep1999 Supplement
VL  - 1
M3  - Book Chapter
SP  - S10
EP  - S11
SN  - 14622203
AB  - Introduces the articles related to nicotine research published in the September 1999 issue of "Nicotine & Tobacco Research."
KW  - SMOKING
KW  - PERIODICALS
N1  - Accession Number: 18755413; Turkkan, Jaylan 1 Condon, Timothy 1; Affiliation:  1: National Institute on Drug Abuse; Source Info: Sep1999 Supplement, Vol. 1, pS10; Subject Term: SMOKING; Subject Term: PERIODICALS; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; Number of Pages: 2p; Document Type: Book Chapter
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Heishman, Stephen J.
T1  - Behavioral and cognitive effects of smoking: Relationship to nicotine addiction.
JO  - Nicotine & Tobacco Research
JF  - Nicotine & Tobacco Research
Y1  - 1999/09/02/Sep1999 Supplement
VL  - 1
M3  - Article
SP  - S143
EP  - S147
SN  - 14622203
AB  - Nicotine addiction is an extremely complex process that involves biological, psychological, behavioral, and cultural factors. Three factors that influence smoking and that are influenced by smoking are performance, stress, and body weight. We know that if nicotine-addicted smokers are deprived of nicotine, attentional and cognitive abilities can be impaired, and such deficits can be reversed if the person smokes or is given nicotine. In nonsmokers and nondeprived smokers, nicotine enhances finger tapping, focused and sustained attention, recognition memory, and reasoning. Stress results in increased smoking, but there is little empirical evidence that smoking reduces stress. Stress reduction from smoking is likely the relief of withdrawal-induced negative mood that is experienced between cigarettes. Smokers weigh on average 3–4 kg less than nonsmokers, and the weight-gain seen after quitting smoking also averages 3–4 kg. Changes in eating and energy expenditure are responsible for the body weight changes seen during smoking cessation and relapse. We need to know the full range of conditions under which nicotine affects behavior. The mechanisms by which stress functions to maintain nicotine addiction are not well understood. We do not know what interventions are effective in addressing the stress experienced during smoking cessation. Because no effective interventions have been developed to prevent weight-gain after quitting, research should focus on the concern or perception of weight-gain. We need to understand how and why body weight concerns vary across gender, age, and ethnicity because of the implications for designing effective smoking-cessation programs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Nicotine & Tobacco Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SMOKING
KW  - NICOTINE addiction
KW  - TOBACCO use
KW  - SMOKING cessation
KW  - STRESS management
KW  - THERAPEUTICS
N1  - Accession Number: 18755414; Heishman, Stephen J. 1; Email Address: sheish@intra.nida.nih.gov; Affiliation:  1: Clinical Pharmacology & Therapeutics Branch, National Institute on Drug Abuse, Baltimore, Maryland; Source Info: Sep1999 Supplement, Vol. 1, pS143; Subject Term: SMOKING; Subject Term: NICOTINE addiction; Subject Term: TOBACCO use; Subject Term: SMOKING cessation; Subject Term: STRESS management; Subject Term: THERAPEUTICS; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107003629
T1  - Reducing treatment delay in MI: the family physician's role.
AU  - Hand MM
AU  - Rodriguez RB
AU  - Atkins JM
Y1  - 1999/09/16/1999 Sep 15 Cardiology in Primary Care: Myocardial Infarction
N1  - Accession Number: 107003629. Language: English. Entry Date: 20010302. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; forms; tables/charts. Supplement Title: 1999 Sep 15 Cardiology in Primary Care: Myocardial Infarction. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8002229. 
KW  - Myocardial Infarction -- Therapy
KW  - Treatment Delay
KW  - Patient Education
KW  - Time Factors
KW  - Myocardial Infarction -- Education
KW  - Triage
KW  - Myocardial Infarction -- Symptoms
KW  - Education, Continuing (Credit)
SP  - 15
EP  - 34
JO  - Family Practice Recertification
JF  - Family Practice Recertification
JA  - FAM PRACT RECERTIF
VL  - 21
IS  - 11
CY  - Plainsboro, New Jersey
PB  - Intellisphere, LLC
AB  - The current treatment paradigm for acute myocardial infarction is the early opening of the infarct-related artery, pharmacologically or mechanically, to reestablish blood flow or reperfusion. But patient and organizational delays in response to heart attack symptoms are the rule rather than the exception because of complex behavioral, interpersonal, and health care delivery system dynamics. Primary care physicians can help reduce patient and health care system delays by identifying patients at highest risk for heart attacks and those most likely to delay seeking treatment and then counseling and educating them. Office triage systems should be in place to minimize the delay to lifesaving treatment.
SN  - 0163-6642
AD  - Coordinator, National Heart Attack Alert Program, Office of Prevention, Education, and Control, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107231852
T1  - Assistance from family members, friends, paid care givers, and volunteers in the care of terminally ill patients.
AU  - Emanuel EJ
AU  - Fairclough DL
AU  - Slutsman J
AU  - Alpert H
AU  - Baldwin D
AU  - Emanual LL
Y1  - 1999/09/23/
N1  - Accession Number: 107231852. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Commonwealth Fund and the Nathan Cummings Foundation. NLM UID: 0255562. 
KW  - Terminally Ill Patients
KW  - Caregivers
KW  - Home Nursing
KW  - Fisher's Exact Test
KW  - Chi Square Test
KW  - Mantel-Haenszel Test
KW  - P-Value
KW  - United States
KW  - Interviews
KW  - Surveys
KW  - Funding Source
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 956
EP  - 963
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 341
IS  - 13
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Dept of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156
U2  - PMID: 10498492.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107084383
T1  - Genetic and environmental influences on eating patterns of twins aged greater than or equals to 50 y.
AU  - van den Bree MBM
AU  - Eaves LJ
AU  - Dwyer JT
Y1  - 1999/10//
N1  - Accession Number: 107084383. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: National Cancer Institute's (26) Semiquantitative Food-Frequency Questionnaire (SFFQ). Grant Information: Supported by grant AA-06781 from the National Institutes of Health (National Institute of Alcohol Abuse and Alcoholism) and gifts from RJR Nabisco corporations and the Gerber Foundation and based on work supported by the US Department of Agriculture under agreement 58-1950-9-001. NLM UID: 0376027. 
KW  - Eating Behavior
KW  - Eating
KW  - Genetics
KW  - Social Environment
KW  - Twins
KW  - Educational Status
KW  - Research Instruments
KW  - Factor Analysis
KW  - Pearson's Correlation Coefficient
KW  - Questionnaires
KW  - Chi Square Test
KW  - Confidence Intervals
KW  - Data Analysis Software
KW  - Middle Age
KW  - Aged
KW  - Female
KW  - Male
KW  - Funding Source
KW  - Human
SP  - 456
EP  - 465
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 70
IS  - 4
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - BACKGROUND: Clinicians and researchers could benefit from a greater understanding of the role of genetic and environmental factors in human eating behavior. OBJECTIVE: Our aim was to estimate the relative influence of genetic and environmental factors on habitual eating patterns in middle-aged and elderly men and women. DESIGN: Male and female twins (n = 4640) aged >/=50 y completed a mailed version of the National Cancer Institute food-frequency questionnaire. Factor analysis was performed to identify eating patterns among respondents. Estimates of genetic, common environmental (shared by family members), and specific environmental (unique to an individual) influences were obtained for food use, serving size, and consumption frequency by comparing monozygotic and dizygotic twin-pair groups with structural equation analysis. RESULTS: Two independent eating patterns were identified: the first consisted of items high in fat, salt, and sugar, and the second reflected healthful eating habits. Although the influence of environmental factors was larger, between 15% and 38% of the total variation in pattern 1 and between 33% and 40% in pattern 2 were explained by genetic influences. Models accounting for sex differences in genetic and environmental estimates fit the data significantly better for food use and serving size of foods in eating pattern 1 and for food use in eating pattern 2. CONCLUSION: Although 60-85% of the variability in eating patterns was associated with environmental factors, genetic influences were also apparent and there was some evidence of sex specificity. These findings may be important in crafting dietary interventions and predicting adherence to these interventions. Copyright (c) 1999 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, PO Box 5180, Baltimore, MD 21224. E-mail: mvandenb@intra.nida.nih.gov
U2  - PMID: 10500013.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Athayde, Neil
AU  - Romero, Roberto
AU  - Athayde, N
AU  - Romero, R
AU  - Maymon, E
AU  - Gomez, R
AU  - Pacora, P
AU  - Araneda, H
AU  - Yoon, B H
T1  - A role for the novel cytokine RANTES in pregnancy and parturition.
JO  - American Journal of Obstetrics & Gynecology
JF  - American Journal of Obstetrics & Gynecology
Y1  - 1999/10//
VL  - 181
IS  - 4
M3  - journal article
SP  - 989
EP  - 994
SN  - 00029378
AB  - <bold>Objective: </bold>RANTES (regulated on activation, normal T cell expressed and secreted), a potent and versatile chemokine, is capable of attracting monocytes, lymphocytes, basophils, and eosinophils. This cytokine has been implicated in the regulation of the inflammatory response and in the recruitment of macrophages to the implantation site in early pregnancy. RANTES messenger ribonucleic acid and protein have been detected in fetal tissue and first-trimester trophoblast in response to bacterial endotoxin. The purpose of this study was to determine whether intrauterine infection, parturition (preterm and term), and gestational age affect the amniotic fluid concentrations of RANTES in human pregnancy.<bold>Study Design: </bold>A cross-sectional study was designed to examine the relationship between labor, microbial invasion of the amniotic cavity, gestational age, and RANTES expression in amniotic fluid. Amniotic fluid was obtained from 214 women in the following groups: (1) midtrimester (n = 22), (2) preterm labor with intact membranes in the presence (n = 20) or absence (n = 74) of microbial invasion of the amniotic cavity, (3) term, not in labor (n = 44) and term, in labor in the presence (n = 27) and absence (n = 27) of microbial invasion of the amniotic cavity. Microbial invasion of the amniotic cavity was defined as a positive amniotic fluid culture for microorganisms. RANTES concentrations were determined by use of a sensitive and specific immunoassay.<bold>Results: </bold>(1) Amniotic fluid RANTES concentrations decrease with advancing gestational age (r = 0. 43; P <.01). (2) Labor at term was associated with an increase in median concentrations of RANTES (labor-median, 8.4 pg/mL; range, <1.3-94.4 vs no labor-median, <1.3 pg/mL; range, <1.3-230.3; P <.01). (3) Women with preterm labor who delivered preterm (no microbial invasion of the amniotic cavity) had a higher median concentration of amniotic fluid RANTES than those who delivered at term (median, 12.7 pg/mL; range, <1.3-928 vs median, <1.3 pg/mL; range, <1.3-127. 5; P <.001). (4) Microbial invasion of the amniotic cavity was associated with a significant increase in median amniotic fluid RANTES in both preterm and term labor (preterm labor with microbial invasion of the amniotic cavity-median, 51.6 pg/mL; range, <1.3-2290 vs preterm labor without microbial invasion of the amniotic cavity-median, 12.7 pg/mL; range, <1.3-928 and vs preterm labor with delivery at term-median, <1.3 pg/mL; range, <1.3-127.5; P <.001 for each; term labor with microbial invasion of the amniotic cavity-median, 16.8 pg/mL; range, <1.3-171.4 vs term labor without microbial invasion of the amniotic cavity-median, 8.4 pg/mL; range, <1.3-94.4; P <.05 and vs no labor and no microbial invasion of the amniotic cavity-median, 1.4 pg/mL; range, <1.3-230.3; P <.001 and P <.05, respectively).<bold>Conclusion: </bold>These results support a role for RANTES in the mechanisms of human parturition and in the regulation of the host response to intrauterine infection. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DELIVERY (Obstetrics)
KW  - AMNIOTIC liquid
KW  - PARTURITION
KW  - PREMATURE labor
KW  - AMNION
KW  - BACTERIA
KW  - CYTOKINES
KW  - GESTATIONAL age
KW  - IMMUNOASSAY
KW  - LABOR (Obstetrics)
KW  - PREGNANCY
KW  - CROSS-sectional method
N1  - Accession Number: 2505186; Athayde, Neil; Romero, Roberto; Athayde, N 1; Romero, R; Maymon, E; Gomez, R; Pacora, P; Araneda, H; Yoon, B H; Source Information: Oct99, Vol. 181 Issue 4, p989; Subject: DELIVERY (Obstetrics); Subject: AMNIOTIC liquid; Subject: PARTURITION; Subject: PREMATURE labor; Subject: AMNION; Subject: BACTERIA; Subject: CYTOKINES; Subject: GESTATIONAL age; Subject: IMMUNOASSAY; Subject: LABOR (Obstetrics); Subject: PREGNANCY; Subject: CROSS-sectional method; Number of Pages: 6p; Illustrations: 3 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
ID  - 107222317
T1  - If the doctor says cancer: what to do next... and next.
AU  - Coleman CN
Y1  - 1999/10//1999 Oct
N1  - Accession Number: 107222317. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 9891730. 
KW  - Neoplasms
KW  - Neoplasms -- Classification
KW  - Neoplasms -- Therapy
KW  - Decision Making, Patient
SP  - 9
EP  - 10
JO  - Bottom Line Health
JF  - Bottom Line Health
JA  - BOTTOM LINE HEALTH
VL  - 13
IS  - 10
CY  - Greenwich, Connecticut
PB  - Health Confidential
SN  - 1092-0129
AD  - National Cancer Institute, Bethesda, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Boheler, Kenneth R.
AU  - Fiszman, Marc Y.
T1  - Can Exogenous Stem Cells Be Used in Transplantation?
JO  - Cells Tissues Organs
JF  - Cells Tissues Organs
Y1  - 1999/10//
VL  - 165
IS  - 3/4
M3  - Article
SP  - 237
EP  - 245
SN  - 14226405
AB  - Today’s most urgent problem in transplantation is the lack of suitable donor organs and tissues and as the population ages, demands for organs and tissue therapies will only increase. One alternative to organ transplantation is cell therapy whose aim is to replace, repair or enhance the biological function of damaged tissue or diseased organs. One goal of cellular transplantation thus has been to find a renewable source of cells that could be used in humans. Embryonic stem (ES) cells have the potential to proliferate in vitro in an undifferentiated and pluripotent state. Theoretically, ES cells are capable of unlimited proliferation in vitro. ES cells spontaneously differentiate into derivatives of all three primary germ layers: endoderm, ectoderm and mesoderm, hence providing cells in vitro which can theoretically be isolated and used for transplantation. Furthermore, these pluripotent stem cells can potentially be used to produce large numbers of cells that can be genetically modified in vitro. Once available, this source of cells may obviate some of the critical needs for organ transplantation. Murine ES cells have been extensively studied and all available evidence indicates that all aforementioned expectations are indeed fulfilled by ES cells. ES cells as well as embryonic germ cells have recently been isolated and maintained in culture. The recent descriptions of human ES cells portend the eventual use of allogeneic in vitro differentiated cells for human therapy. This goal, however, is fraught with obstacles. Our aim is first to review the recent advances made with murine ES cells and then to point out potentials and difficulties associated with the use of human ES cells for transplantation.Copyright © 1999 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB  - Copyright of Cells Tissues Organs is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EMBRYONIC stem cells
KW  - STEM cells
KW  - CELL transplantation
KW  - CELLULAR therapy
KW  - PHYSIOLOGICAL therapeutics
KW  - Cell replacement therapy
KW  - Embryonic stem cells
N1  - Accession Number: 11374758; Boheler, Kenneth R. 1; Email Address: mfiszman@myologie.infobiologen.fr Fiszman, Marc Y. 2; Affiliation:  1: National Institute on Aging, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, Baltimore, Md., USA  2: INSERM U523, Institute of Myology, Hôpital Pitié-Salpêtrière, Paris, France; Source Info: 1999, Vol. 165 Issue 3/4, p237; Subject Term: EMBRYONIC stem cells; Subject Term: STEM cells; Subject Term: CELL transplantation; Subject Term: CELLULAR therapy; Subject Term: PHYSIOLOGICAL therapeutics; Author-Supplied Keyword: Cell replacement therapy; Author-Supplied Keyword: Embryonic stem cells; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3  - 10.1159/000016684
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DB  - aph
ER  - 

TY  - JOUR
AU  - Kastelein, John Jp
AU  - Ordovas, Jose M
AU  - Wittekoek, Marianne E
AU  - Pimstone, Simon N
AU  - Wilson, Peter Wf
AU  - Gagné, S Eric
AU  - Larson, Martin G
AU  - Schaefer, Ernest J
AU  - Boer, Jolanda Ma
AU  - Gerdes, Christian
AU  - Hayden, Michael R
T1  - Two common mutations (D9N, N291S) in lipoprotein lipase: a cumulative analysis of their influence on plasma lipids and lipoproteins in men and women.
JO  - Clinical Genetics
JF  - Clinical Genetics
Y1  - 1999/10//
VL  - 56
IS  - 4
M3  - Article
SP  - 297
EP  - 305
PB  - Wiley-Blackwell
SN  - 00099163
AB  - We assessed the effect of two common mutations in the lipoprotein lipase gene (LPL), D9N and N291S, which have been shown to modulate plasma lipids in a wide spectrum of patients.A total of 1 114 men and 1 144 women from the Framingham Offspring Study (FOS) were analyzed for these two LPL variants. Subsequently, the association with fasting plasma lipids and risk of coronary artery disease (CHD) was determined. We extended our study by calculating weighed means of lipids and lipoproteins in carriers and non-carriers for these LPL mutations in patients with genetic dyslipidemias, CHD patients and healthy controls.In the FOS sample, the D9N and N291S alleles were associated with lower high-density lipoprotein-cholesterol (HDL-C) (Δ=-0.07 mmol/l, p=0.03) and a trend towards increased triglycerides (Δ=0.25 mmol/l, p=0.07). In women, a trend towards the high triglyceride, low HDL-C phenotype was evident (Δ=-0.02 mmol/l for HDL-C and Δ=0.14 mmol/l for triglycerides, respectively). Cumulative analysis of other studies of male carriers of the D9N and N291S revealed higher levels of triglycerides (D291N; 2.60(1.85) mmol/l vs. 1.62(1.18) mmol/l: p<0.0001) (D9N; 1.94 (1.19) mmol/l vs. 1.74(1.17) mmol/l: p<0.001) and lower HDL-C (N291S; 1.04(0.32) mmol/l vs. 1.15(0.28) mmol/l: p<0.0001) (D9N; 1.08(0.24) mmol/l vs. 1.16(0.28) mmol/l: p<0.0001). In females, results differed with higher TG levels (N291S; 1.70(0.99) mmol/l vs. 1.10(0.63) mmol/l: p<0.001) (D9N; 1.08(0.76) mmol/l vs. 0.96(0.51) mmol/l: p<0.01) and lower HDL-C levels (N291S; 1.27(0.33) mmol/l vs. 1.51(0.32) mmol/l: p<0.0001); however, the HDL-C levels for D9N carriers were similar to non-carriers (D9N; 1.52(0.29) mmol/l vs. 1.53(0.35) mmol/l: p=0.83).Our data provide evidence that common variants of the LPL gene are significant modulators of lipid and lipoprotein levels in both men and women. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MUTATION (Biology)
KW  - LIPOPROTEINS
KW  - genetics
KW  - lipids
KW  - lipoprotein lipase
KW  - lipoproteins
KW  - mutation
N1  - Accession Number: 5304672; Kastelein, John Jp 1 Ordovas, Jose M 2 Wittekoek, Marianne E 1 Pimstone, Simon N 3 Wilson, Peter Wf 4 Gagné, S Eric 3 Larson, Martin G 4 Schaefer, Ernest J 2 Boer, Jolanda Ma 5 Gerdes, Christian 6 Hayden, Michael R 3; Affiliation:  1: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,  2: Lipid Metabolism Laboratory, US Department of Agriculture, Human Nutrition Research, Center on Aging at TUFTS, University, Boston, USA,  3: Department of Medical Genetics, University of British Columbia, Vancouver BC, Canada,  4: Framingham Heart Study, National Heart, Lung and Blood Institute and Boston University, Boston, USA,  5: Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and Environment, Bilthoven, The Netherlands,  6: Department of Medicine and Cardiology, Åarhus University Hospital, Åarhus, The Netherlands; Source Info: Oct99, Vol. 56 Issue 4, p297; Subject Term: MUTATION (Biology); Subject Term: LIPOPROTEINS; Author-Supplied Keyword: genetics; Author-Supplied Keyword: lipids; Author-Supplied Keyword: lipoprotein lipase; Author-Supplied Keyword: lipoproteins; Author-Supplied Keyword: mutation; Number of Pages: 9p; Document Type: Article
L3  - 10.1034/j.1399-0004.1999.560407.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Wilks, R.
AU  - Rotimi, C.
AU  - Bennett, F.
AU  - McFarlane-Anderson, N.
AU  - Kaufman, J. S.
AU  - Anderson, S. G.
AU  - Cooper, R. S.
AU  - Cruickshank, J. K.
AU  - Forrester, T.
T1  - Diabetes in the Caribbean: results of a population survey from Spanish Town, Jamaica.
JO  - Diabetic Medicine
JF  - Diabetic Medicine
Y1  - 1999/10//
VL  - 16
IS  - 10
M3  - Article
SP  - 875
EP  - 883
PB  - Wiley-Blackwell
SN  - 07423071
AB  - SummaryAims To characterize the prevalence of diabetes and associated risk attributes in the Jamaican population. Methods A random population sample was recruited by door-to-door canvassing (n = 1303). A final participation of 60% was achieved. Oral glucose tolerance testing was conducted after an overnight fast and standard anthropometric and demographic data were collected. Results The prevalence of Type 2 diabetes mellitus was 9.8% (95% confidence interval (CI) 7.2–12.4) among men and 15.7% (95% CI 13.1–18.3) among women with an overall prevalence of 13.4% (95% CI 11.5–15.2). Impaired glucose tolerance was found among 12.3% of men and 14.7% of women. The sex patterns were consistent with a fourfold excess of obesity in women compared to men. The odds ratios for diabetes, fourth vs. first quartiles were 5.42 (95% CI 2.02–16.88) in men and 3.32 (95% CI 1.73–6.63) in women for body mass index (BMI) and 17.39 (95% CI 3.86–78.27) in men and 5.48 (95% CI 2.84–11.00) in women for WHR in a logistic model controlling for age. The population attributes risk percentage, for diabetes, of being overweight and having waist-to-hip ratio (WHR) greater than the median (0.80) were 66% and 80%, respectively. The contribution of central obesity, as characterized by WHR, was also significant in sex-specific multivariate models that included age and BMI. Prevalent hypertension and family history of diabetes were likewise associated with increased odds of having the disease. Conclusions The prevalence of diabetes in Jamaica now exceeds that observed among European-origin populations and reflects the emerging epidemic of obesity. The excess risk for this population could not be attributed entirely to relative weight. The pronounced sexual dimorphism in diabetes prevalence most likely reflects the substantial excess of obesity among women compared to men. Like many other island nations, Caribbean societies now appear to be at... [ABSTRACT FROM AUTHOR]
AB  - Copyright of Diabetic Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIABETES
KW  - DEMOGRAPHIC surveys
KW  - POPULATION
KW  - JAMAICA
KW  - Caribbean
KW  - Jamaica
KW  - obesity
KW  - Type 2 diabetes mellitus
N1  - Accession Number: 5186688; Wilks, R. 1 Rotimi, C. 2 Bennett, F. 1 McFarlane-Anderson, N. 1 Kaufman, J. S. 2 Anderson, S. G. 1 Cooper, R. S. 2 Cruickshank, J. K. 3 Forrester, T. 1; Affiliation:  1: Tropical Metabolism Research Unit, University of the West Indies, Mona, Jamaica  2: Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood IL, USA  3: Clinical Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK Supported in part by grants from the US National Institutes of Health, the European Commission and the Wellcome Trust; Source Info: Oct1999, Vol. 16 Issue 10, p875; Subject Term: DIABETES; Subject Term: DEMOGRAPHIC surveys; Subject Term: POPULATION; Subject Term: JAMAICA; Author-Supplied Keyword: Caribbean; Author-Supplied Keyword: Jamaica; Author-Supplied Keyword: obesity; Author-Supplied Keyword: Type 2 diabetes mellitus; Number of Pages: 9p; Document Type: Article
L3  - 10.1046/j.1464-5491.1999.00151.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Mongioví, Adriana Maria
AU  - Romano, Pascale R.
AU  - Panni, Simona
AU  - Mendoza, Manuel
AU  - Wong, William T.
AU  - Musacchio, Andreas
AU  - Cesareni, Gianni
AU  - di Fiore, Pier Paolo
T1  - A novel peptide-SH3 interaction.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/10//10/1/99
VL  - 18
IS  - 19
M3  - Article
SP  - 5300
EP  - 5309
SN  - 02614189
AB  - SH3 domains constitute a family of protein-protein interaction modules that bind to peptides displaying an X-proline-X-X-proline (XPXXP) consensus. We report that the SH3 domain of Eps8, a substrate of receptor and non-receptor tyrosine kinases, displays a novel and unique binding preference. By a combination of approaches including (i) screening of phage-displayed random peptide libraries, (ii) mapping of the binding regions on three physiological interactors of EpsS, (iii) alanine scanning of binding peptides and (iv) in vitro cross-linking, we demonstrate that a proline-X-X-aspartate-tyrosine (PXXDY) consensus is indispensable for binding to the SH3 domain of Eps8. Screening of the Expressed Sequence Tags database allowed the identification of three Eps8-related genes, whose SH3s also display unusual binding preferences and constitute a phylogenetically distinct subfamily within the SH3 family. Thus, Eps8 identifies a novel family of SH3-containing proteins that do not bind to canonical XPXXP-containing peptides, and that establish distinct interactions in the signaling network. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CELLULAR signal transduction
KW  - PEPTIDES
KW  - CARRIER proteins
KW  - PROLINE
KW  - PROTEIN-protein interactions
KW  - BINDING sites (Biochemistry)
KW  - eps8
KW  - sh3
KW  - signal transduction
N1  - Accession Number: 13004324; Mongioví, Adriana Maria 1 Romano, Pascale R. 1 Panni, Simona 2 Mendoza, Manuel 2 Wong, William T. 3 Musacchio, Andreas 1 Cesareni, Gianni 2 di Fiore, Pier Paolo 1; Email Address: pdifiore@ieo.cilea.it; Affiliation:  1: Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan  2: Department of Biology, Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4330, USA  3: Istituto di Microbiologia, University of Bari, Bari, Italy; Source Info: 10/1/99, Vol. 18 Issue 19, p5300; Subject Term: CELLULAR signal transduction; Subject Term: PEPTIDES; Subject Term: CARRIER proteins; Subject Term: PROLINE; Subject Term: PROTEIN-protein interactions; Subject Term: BINDING sites (Biochemistry); Author-Supplied Keyword: eps8; Author-Supplied Keyword: sh3; Author-Supplied Keyword: signal transduction; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/18.19.5300
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Sasaki, Shigekazu
AU  - Lesoon-Wood, Leslie A.
AU  - Dey, Anup
AU  - Kuwata, Takeshi
AU  - Weintraub, Bruce D.
AU  - Humphrey, Glen
AU  - Wen-Ming Yang
AU  - Seto, Edward
AU  - Yen, Paul M.
AU  - Howard, Bruce H.
AU  - Ozato, Keiko
T1  - Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin ß gene.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/10//10/1/99
VL  - 18
IS  - 19
M3  - Article
SP  - 5389
EP  - 5398
SN  - 02614189
AB  - We have investigated ligand-dependent negative regulation of the thyroid-stimulating hormone β (TSHβ) gene. Thyroid hormone(T3) markedly repressed activity of the TSHβ promoter that had been stably integrated into GH3 pituitary cells, through the conserved negative regulatory element (NRE) in the promoter. By DNA affinity binding assay, we show that the NRE constitutively binds to the histone deacetylase 1 (HDAC1) present in GH3 cells. Significantly, upon addition of T3, the NRE further recruited the thyroid hormone receptor (TRβ) and another deacetylase, HDAC2. This recruitment coincided with an alteration of in vivo chromatin structure, as revealed by changes in restriction site accessibility. Supporting the direct interaction between TR and HDAC, in vitro assays showed that TR, through its DNA binding domain, strongly bound to HDAC2. Consistent with the role for HDACs in negative regulation, an inhibitor of the enzymes, trichostatin A, attenuated T3-dependent promoter repression. We suggest that ligand-dependent histone deacetylase recruitment is a mechanism of the negative-feedback regulation, a critical function of the pituitary-thyroid axis. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HISTONE deacetylase
KW  - THYROTROPIN
KW  - THYROID hormones
KW  - HORMONE receptors
KW  - BINDING sites (Biochemistry)
KW  - PROMOTERS (Genetics)
KW  - GENETIC transcription -- Regulation
KW  - MOLECULAR genetics
KW  - histone deacetylases
KW  - negative feedback
KW  - thyroid hormone
KW  - thyrotropin
N1  - Accession Number: 13004316; Sasaki, Shigekazu 1,2 Lesoon-Wood, Leslie A. 3 Dey, Anup 1 Kuwata, Takeshi 1 Weintraub, Bruce D. 4 Humphrey, Glen 1 Wen-Ming Yang 5 Seto, Edward 5 Yen, Paul M. 6 Howard, Bruce H. 1 Ozato, Keiko 1; Email Address: Ozatok@nih.gov; Affiliation:  1: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-2753  2: Second Department of Internal Medicine, Hammatsu University, School of Medicine, 3600 Handa-cho, Hammatsu 431-3192, Japan  3: Molecular Carcinogenesis, Cancer Research Center of Hawaii, University of Hawaii, 96813  4: Division of Endocrinology, University of Maryland, School of Medicine and Laboratory of Molecular Endocrinology, Institute of Human Virology, Baltimore, MD 21201  5: H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida, Tampa, FL 33612, USA  6: Clinical Endocrinology Branch, National Institute of Diabetes and Digetive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-2753; Source Info: 10/1/99, Vol. 18 Issue 19, p5389; Subject Term: HISTONE deacetylase; Subject Term: THYROTROPIN; Subject Term: THYROID hormones; Subject Term: HORMONE receptors; Subject Term: BINDING sites (Biochemistry); Subject Term: PROMOTERS (Genetics); Subject Term: GENETIC transcription -- Regulation; Subject Term: MOLECULAR genetics; Author-Supplied Keyword: histone deacetylases; Author-Supplied Keyword: negative feedback; Author-Supplied Keyword: thyroid hormone; Author-Supplied Keyword: thyrotropin; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/18.19.5389
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004316&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Westergaard, Gregory Charles
AU  - Wagner, Joseph L.
AU  - Suomi, Stephen J.
T1  - Manipulative Tendencies of Captive Cebus albifrons.
JO  - International Journal of Primatology
JF  - International Journal of Primatology
Y1  - 1999/10//
VL  - 20
IS  - 5
M3  - Article
SP  - 751
EP  - 759
PB  - Springer Science & Business Media B.V.
SN  - 01640291
AB  - We conducted two experiments to examine the manipulative tendencies of captive Cebus albifrons. In Experiment 1 we examined hand preference for reaching by providing subjects with food either on the cage floor (to facilitate quadrupedal reaching) or at the height of an upright subject's shoulder (to facilitate bipedal reaching). In Experiment 2 we examined combinatorial manipulation by providing subjects with nesting containers and other portable manipulanda. Results indicate that C. albifrons exhibits greater use of the right hand for bipedal versus quadrupedal reaching (exhibiting a group-level lack of bias for bipedal reaching and a left-hand bias for quadrupedal reaching), combines objects using a simple pairing strategy, and uses and produces simple tools. Aspects of these findings parallel those for Cebus apella. [ABSTRACT FROM AUTHOR]
AB  - Copyright of International Journal of Primatology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Capuchin monkeys
KW  - Animal behavior
KW  - Capuchin
KW  - hand preference
KW  - reaching posture
KW  - tool use
N1  - Accession Number: 2609155; Westergaard, Gregory Charles 1; Wagner, Joseph L. 2; Suomi, Stephen J. 1; Affiliations: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, P.O. Box 529, Poolesville, Maryland 20837. Present address: LABS of Virginia, Inc., P.O. Box 557, Yemassee, South Carolina 29945; 2: The Mannheimer Foundation, Inc., 20255 SW 360 St., Homestead, Florida 33034; Issue Info: Oct99, Vol. 20 Issue 5, p751; Thesaurus Term: Capuchin monkeys; Thesaurus Term: Animal behavior; Author-Supplied Keyword: Capuchin; Author-Supplied Keyword: hand preference; Author-Supplied Keyword: reaching posture; Author-Supplied Keyword: tool use; Number of Pages: 9p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 89170081
T1  - Randomized phase II study of high-dose paclitaxel with or without amifostine in patients with metastatic breast cancer.
AU  - Gelmon, K.
AU  - Eisenhauer, E.
AU  - Bryce, C.
AU  - Tolcher, A.
AU  - Mayer, L.
AU  - Tomlinson, E.
AU  - Zee, B.
AU  - Blackstein, M.
AU  - Tomiak, E.
AU  - Yau, J.
AU  - Batist, G.
AU  - Fisher, B.
AU  - Iglesias, J.
Y1  - 1999/10//10/1/1999
N1  - Accession Number: 89170081. Language: English. Entry Date: 19991201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Sensory Integration and Praxis Tests (SIPT) (Ayres). NLM UID: 8309333. 
KW  - Paclitaxel -- Adverse Effects
KW  - Amifostine -- Therapeutic Use
KW  - Radiation-Protective Agents -- Therapeutic Use
KW  - Breast Neoplasms -- Drug Therapy
KW  - Antineoplastic Agents -- Adverse Effects
KW  - Treatment Outcomes
KW  - Human
KW  - Adult
KW  - Aged
KW  - Female
KW  - Paclitaxel -- Administration and Dosage
KW  - Vomiting -- Chemically Induced
KW  - Middle Age
KW  - Drug Administration Schedule
KW  - Fatigue -- Chemically Induced
KW  - Breast Neoplasms -- Pathology
KW  - Antineoplastic Agents -- Administration and Dosage
KW  - Combined Modality Therapy
KW  - Alopecia -- Chemically Induced
KW  - Nausea -- Chemically Induced
KW  - Clinical Trials
KW  - Validation Studies
KW  - Comparative Studies
KW  - Evaluation Research
KW  - Multicenter Studies
KW  - Randomized Controlled Trials
SP  - 3038
EP  - 3047
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 10
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: To determine whether the neurotoxicity of paclitaxel 250 mg/m(2) given over 3 hours every 3 weeks could be reduced by pretreatment with amifostine 910 mg/m(2). Secondary objectives included comparing myelosuppression, myalgias, and response rates of the two groups.Patients and Methods: Forty women with metastatic breast cancer were randomized to receive either paclitaxel alone (arm 1) or paclitaxel preceded by amifostine (arm 2). All were assessable for toxicity, and 37 were assessable for response. At baseline and after each cycle, all patients completed questionnaires for neurologic symptoms and had standardized neurologic examinations, including objective assessments of power and vibration sense. In addition, standard follow-up assessments for other toxicities and tumor response were undertaken. Changes from baseline after courses 1, 2, and 3 were assessed. The sample size was sufficient to detect a 50% improvement in the expected determination in sensory change.Results: There were no differences observed in any of the measures of neurotoxicity. Other toxicity was similar in arms 1 and 2, including hair loss (95% v 90%), neurosensory changes (100% v 100%), fatigue/lethargy (85% v 90%), myalgia (95% v 90%), and grade 4 neutropenia (47% v 60%). Nausea, vomiting, dizziness, hypotension, and sneezing were more common in the amifostine arm. Response rates (22.2% v 36.8%) and paclitaxel pharmacokinetics were not significantly different.Conclusion: There was no protection from paclitaxel-related neurotoxicity or hematologic toxicity in this study. These results suggest that the mechanism of action of paclitaxel-related toxic effects is not amenable to the cytoprotective action of amifostine.
SN  - 0732-183X
AD  - British Columbia Cancer Agency, Vancouver, Canada
AD  - National Cancer Institute of Canada Clinical Trials Group, Kingston, Canada
AD  - Mount Sinai Hospital, Toronto, Canada
AD  - Eli Lilly Company, Toronto, Canada
AD  - Ottawa Regional Cancer Centre, Ottawa, Canada
AD  - McGill University, Montreal, Canada
U2  - PMID: 10506598.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89170091
T1  - Increased incidence of Hodgkin's disease after allogeneic bone marrow transplantation.
AU  - Rowlings, Philip A.
AU  - Curtis, Rochelle E.
AU  - Passweg, Jakob R.
AU  - Deeg, H. Joachim
AU  - Socié, Gérard
AU  - Travis, Lois B.
AU  - Kingma, Douglas W.
AU  - Jaffe, Elaine S.
AU  - Sobocinski, Kathleen A.
AU  - Horowitz, Mary M.
AU  - Rowlings, P A
AU  - Curtis, R E
AU  - Passweg, J R
AU  - Deeg, H J
AU  - Socié, G
AU  - Travis, L B
AU  - Kingma, D W
AU  - Jaffe, E S
AU  - Sobocinski, K A
AU  - Horowitz, M M
Y1  - 1999/10//10/1/1999
N1  - Accession Number: 89170091. Language: English. Entry Date: 19991201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333. 
KW  - Bone Marrow Transplantation -- Adverse Effects
KW  - Neoplasms, Second Primary -- Etiology
KW  - Hodgkin's Disease -- Etiology
KW  - Infant, Newborn
KW  - Child
KW  - Incidence
KW  - Epstein-Barr Virus
KW  - Epstein-Barr Virus Infections -- Complications
KW  - Middle Age
KW  - Graft Versus Host Disease -- Complications
KW  - Case Control Studies
KW  - Child, Preschool
KW  - Aged
KW  - Male
KW  - Adolescence
KW  - Risk Assessment
KW  - Adult
KW  - Immunity, Cellular
KW  - Infant
KW  - Retrospective Design
KW  - Hodgkin's Disease -- Epidemiology
KW  - Neoplasms, Second Primary -- Epidemiology
KW  - Allografts
KW  - Female
KW  - Human
SP  - 3122
EP  - 3127
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 10
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
AB  - Purpose: Immune dysregulation associated with allogeneic bone marrow transplantation (BMT) is linked to an increased risk of posttransplant lymphoproliferative disorders (PTLD); however, reports of Hodgkin's disease (HD) after transplantation are rare.Patients and Methods: We evaluated the risk of HD among 18,531 persons receiving allogeneic BMT between 1964 and 1992 at 235 centers. The number of HD cases was compared with that expected in the general population. Risk factors were identified using Poisson regression and a nested case-control study.Results: Risk of HD was increased in the postBMT population compared with the general population with an observed-to-expected incidence ratio (O/E) of 6.2 (observed cases, n = 8; 95% confidence interval [CI], 2.7 to 12). A significantly increased risk of HD remained after excluding two human immunodeficiency virus-positive patients (observed cases, n = 6; O/E = 4.7, 95% CI, 1.7 to 10.3). Mixed cellularity subtype predominated (five of eight cases, 63%). Five of six assessable cases contained Epstein-Barr virus (EBV) genome. Posttransplant HD differed from PTLD by later onset (> 2.5 years) and lack of association with established risk factors (such as T-cell depletion and HLA disparity). Patients with HD were more likely than matched controls to have had grade 2 to 4 acute graft-versus-host disease (GVHD), required therapy for chronic GVHD, or both (P =.002), although analysis included small numbers of patients.Conclusion: The increased incidence of HD among BMT recipients adds support to current theories which link overstimulation of cell-mediated immunity and exposure to EBV with various subtypes of HD. The long latency of HD after transplant and lack of association with risk factors for PTLD is noteworthy and should be explored further for possible insights into pathogenesis.
SN  - 0732-183X
AD  - International Bone Marrow Transplant Registry, Medical College of Wisconsin, Milwaukee, WI
AD  - Division of Cancer Epidemiology and Genetics and Division of Cancer Biology and Diagnosis, Laboratory of Pathology, National Cancer Institute, Bethesda, MD
AD  - Fred Hutchinson Cancer Research Center, Seattle, WA
AD  - University of Washington, Seattle, WA
AD  - Department of Haematology, Prince of Wales Hospital, Randwick, New South Wales, Australia
AD  - Department Innere Medizin, Kantonsspital, Basel, Switzerland
AD  - Hôpital Saint Louis, Hématologie-Greffe de Moelle, Paris, France
AD  - International Bone Marrow Transplant Registry, Medical College of Wisconsin, Milwaukee, WI, USA
U2  - PMID: 10506608.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 89170109
T1  - Counseling and DNA testing for individuals perceived to be genetically predisposed to melanoma: A consensus statement of the Melanoma Genetics Consortium.
AU  - Kefford, Richard F.
AU  - Bishop, Julia A. Newton
AU  - Bergman, Wilma
AU  - Tucker, Margaret A.
AU  - Kefford, R F
AU  - Newton Bishop, J A
AU  - Bergman, W
AU  - Tucker, M A
Y1  - 1999/10//10/1/1999
N1  - Accession Number: 89170109. Language: English. Entry Date: 19991201. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Perceived Stress Scale (PSS) (Cohen et al). NLM UID: 8309333. 
KW  - Melanoma
KW  - Genetic Counseling
KW  - Disease Susceptibility
KW  - Skin Neoplasms
KW  - Risk Assessment
KW  - Transferases -- Analysis
KW  - DNA -- Analysis
KW  - Proteins -- Analysis
KW  - Genetic Screening -- Standards
KW  - Melanoma -- Pathology
KW  - Skin Neoplasms -- Pathology
KW  - Scales
SP  - 3245
EP  - 3251
JO  - Journal of Clinical Oncology
JF  - Journal of Clinical Oncology
JA  - J CLIN ONCOL
VL  - 17
IS  - 10
CY  - Alexandria, Virginia
PB  - American Society of Clinical Oncology
SN  - 0732-183X
AD  - Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, New South Wales, Australia
AD  - Imperial Cancer Research Fund (ICRF) Cancer Medicine Research Unit, St James's University Hospital, Leeds, United Kingdom
AD  - ICRF Genetic Epidemiology, St James's University Hospital, Leeds, United Kingdom
AD  - Leiden University Medical Centre, Leiden, Netherlands
AD  - National Cancer Institute, Rockville, MD
U2  - PMID: 10506626.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Burton, Stephan L.
AD  - National Institutes of Health
T1  - Why Liberals Should Embrace Managed Care
JO  - Journal of Health Politics, Policy and Law
JF  - Journal of Health Politics, Policy and Law
Y1  - 1999/10//
VL  - 24
IS  - 5
SP  - 911
EP  - 919
SN  - 03616878
N1  - Accession Number: 0514209; Keywords: Managed Care; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200005
KW  - Analysis of Health Care Markets          I11
KW  - Health: Government Policy; Regulation; Public Health          I18
L3  - http://jhppl.dukejournals.org/content/by/year
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UR  - http://jhppl.dukejournals.org/content/by/year
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
AU  - Titlow, Karen
AU  - Emanuel, Ezekiel
AD  - National Institutes of Health
AD  - National Institutes of Health
T1  - Employer Decisions and the Seeds of Backlash
JO  - Journal of Health Politics, Policy and Law
JF  - Journal of Health Politics, Policy and Law
Y1  - 1999/10//
VL  - 24
IS  - 5
SP  - 941
EP  - 947
SN  - 03616878
N1  - Accession Number: 0514212; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200005
KW  - Analysis of Health Care Markets          I11
KW  - Health: Government Policy; Regulation; Public Health          I18
L3  - http://jhppl.dukejournals.org/content/by/year
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UR  - http://jhppl.dukejournals.org/content/by/year
DP  - EBSCOhost
DB  - ecn
ER  - 

TY  - JOUR
ID  - 106892634
T1  - Cnacer knowledge and misconceptions among immigrant Salvadorean men in the Washington, D.C. area.
AU  - Ratnasinghe D
AU  - Weed DL
AU  - Shankar S
Y1  - 1999/10//
N1  - Accession Number: 106892634. Language: English. Entry Date: 20020118. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Peer Reviewed; USA. Grant Information: Grant No. 93-135 from the Midatlantic Research Institute, and the Preventive Oncology Academic Award (CA61807) from the National Cancer Institute. NLM UID: 9815654. 
KW  - Health Knowledge
KW  - Health Beliefs
KW  - Immigrants -- District of Columbia
KW  - Hispanics -- District of Columbia
KW  - Neoplasms
KW  - District of Columbia
KW  - Male
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - El Salvador
KW  - Cross Sectional Studies
KW  - Surveys
KW  - Neoplasms -- Etiology
KW  - Neoplasms -- Symptoms
KW  - Neoplasms -- Diagnosis
KW  - Cancer Screening
KW  - Neoplasms -- Ethnology
KW  - Health Services Accessibility
KW  - Health Education
KW  - Data Analysis Software
KW  - Descriptive Statistics
KW  - Multivariate Analysis
KW  - Logistic Regression
KW  - Step-Wise Multiple Regression
KW  - Insurance, Health
KW  - Funding Source
KW  - Human
SP  - 207
EP  - 213
JO  - Journal of Immigrant Health
JF  - Journal of Immigrant Health
JA  - J IMMIGRANT HEALTH
VL  - 1
IS  - 4
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - Although Salvadoreans are the fourth largest group of Hispanics in the United States, little is known about their cancer knowledge, attitudes, and practices. There are no publications assessing cancer knowledge among Salvadorean men. In this cross-sectional survey, information was gathered from 706 immigrant Salvadorean men in Washington, D.C. The majority of these men knew that smoking causes cancer and that some cancers can be cured if detected early. However, the men in this survey had inadequate knowledge about symptoms of cancer and early detection methods. The most important predictor of cancer screening among older participants was enrollment in health insurance plans. Our study suggests that Salvadorean men would participate in cancer screening efforts if they had access to medical care. Educational programs to increase awareness of cancer and availability of preventive services may help prevent cancer in this population.
SN  - 1096-4045
AD  - Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Burke, Zoe
AU  - Wells, Tim
AU  - Carter, David
AU  - Klein, David
AU  - Baler, Ruben
T1  - Genetic Targeting.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/10//
VL  - 73
IS  - 4
M3  - Article
SP  - 1343
EP  - 1349
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Abstract: The arylalkylamine N-acetyltransferase (AA-NAT) gene is strongly expressed in the rat primarily in the pineal gland ; low levels of expression are also found in the retina. AA-NAT catalyzes the key regulatory step controlling rhythmic melatonin output: the acetylation of serotonin. In the rat, the AA-NAT gene is expressed at night. This is controlled partly by cyclic AMP (cAMP) acting through a composite cAMP-responsive element-CCAAT site located upstream of the transcription start point. In the present study, we have extended our previous in vitro findings and found that additional elements in the 5′ flanking region and first intron play an important role in the regulation of the AA-NAT gene. This led us to test the influence of an AA-NAT 5′ flanking segment on the expression of the bacterial chloramphenicol acetyltransferase gene in a rat transgenic model. The results of this study clearly demonstrate that the segment of the AA-NAT gene that encompasses the minimal promoter and the first intron is able to confer the highly specific pineal/retinal and time-of-day patterns of AA-NAT gene expression. This advance also provides a tool that selectively targets genetic expression to pinealocytes and retinal photoreceptors, providing new experimental opportunities to probe gene expression in these tissues. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SEROTONIN
KW  - ACETYLTRANSFERASES
KW  - CATALYST supports
KW  - Circadian rhythm
KW  - Pineal gland
KW  - Rat arylalkylamine N-acetyltransf
KW  - retina.
N1  - Accession Number: 6822354; Burke, Zoe Wells, Tim Carter, David 1 Klein, David 2 Baler, Ruben; Affiliation:  1: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland, U.S.A.  2: Unit on Temporal Gene Expression, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct99, Vol. 73 Issue 4, p1343; Subject Term: SEROTONIN; Subject Term: ACETYLTRANSFERASES; Subject Term: CATALYST supports; Author-Supplied Keyword: Circadian rhythm; Author-Supplied Keyword: Pineal gland; Author-Supplied Keyword: Rat arylalkylamine N-acetyltransf; Author-Supplied Keyword: retina.; Number of Pages: 7p; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0731343.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107231786
T1  - Terminal cancer patients and timing of referral to palliative care: a multicenter prospective cohort study.
AU  - Costantini M
AU  - Toscani F
AU  - Gallucci M
AU  - Brunelli C
AU  - Miccinesi G
AU  - Tamburini M
AU  - Paci E
AU  - Di Giulio P
AU  - Peruselli C
AU  - Higginson I
AU  - Addington-Hall J
Y1  - 1999/10//1999 Oct
N1  - Accession Number: 107231786. Corporate Author: Italian Cooperative Research Group on Palliative Medicine. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836. 
KW  - Terminally Ill Patients
KW  - Cancer Patients
KW  - Referral and Consultation
KW  - Palliative Care
KW  - Prospective Studies
KW  - Random Sample
KW  - Quality of Life
KW  - Survival Analysis
KW  - Chi Square Test
KW  - Logistic Regression
KW  - Kaplan-Meier Estimator
KW  - Descriptive Statistics
KW  - Age Factors
KW  - Sex Factors
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Hospices
KW  - Italy
KW  - Human
SP  - 243
EP  - 252
JO  - Journal of Pain & Symptom Management
JF  - Journal of Pain & Symptom Management
JA  - J PAIN SYMPTOM MANAGE
VL  - 18
IS  - 4
CY  - New York, New York
PB  - Elsevier Science
AB  - This study describes the characteristics of a representative sample of terminally ill cancer patients at admission to Italian palliative care programs, the rate and reasons for discontinuation of care, and survival after enrollment. All Italian palliative care units (PCUs) specifically committed to palliative care were asked to consecutively register all new patients (n = 3901) between January and June, 1995. Fifty-eight of the 62 PCUs contacted by the Steering Committee completed the study. A random sample of 589 evaluable patients was prospectively selected from the 2667 eligible patients. Patients were mostly referred by a general practitioner (31.2%) or a specialist (42.1%). Most patients (84.7%) were followed until death. Seventy-seven discontinued care because of hospital admission (6.6%), change of residence (3.9%), refusal (1.7%), or improvement (0.8%). Median survival was 37.9 days; 14.3% of the patients died within 7 days, and 15.3% lived longer than 180 days. A statistically significant association between survival and gender, cancer type, setting of the first visit, and type of unit was observed. In Italy, as in other countries with different health systems, referral of cancer patients to palliative care tends to occur late in the course of the disease. This study suggests that the process of enrollment and the duration of patients' survival in palliative care, when studied in large unselected populations, can provide important information relevant to the care of terminally ill patients. (c) U.S. Cancer Pain Relief Committee, 1999.
SN  - 0885-3924
AD  - Clinical Epidemiology and Trials Unit, National Cancer Institute, L.go R.Benzi 10, 16132, Genoa, Italy
U2  - PMID: 10534964.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Sheikh, Aantir
AU  - Horowitz, Alice M.
T1  - Benefits of Fluoride Toothpaste.
JO  - Journal of School Health
JF  - Journal of School Health
Y1  - 1999/10//
VL  - 69
IS  - 8
M3  - Article
SP  - 299
EP  - 299
PB  - Wiley-Blackwell
SN  - 00224391
N1  - Accession Number: 95573743; Sheikh, Aantir 1 Horowitz, Alice M. 2; Affiliation:  1: Health Research Specialist, National Institutes of Health, National Institute of Dental and Craniofacial Research, Bldg. 45, Room 3-AN-44, Bethesda, MD 20892-6401  2: Senior Scientist, National Institutes of Health, National Institute of Dental and Craniofacial Research, Bldg. 45, Room 3-AN-44, Bethesda, MD 20892-6401; Source Info: Oct1999, Vol. 69 Issue 8, p299; Number of Pages: 2/3p; Document Type: Article
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=95573743&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107102959
T1  - Benefits of fluoride toothpaste...'Bright smiles, shining futures' by Drs. Yehieli and Koch published in the April 1999 issue of Journal of School Health (1999;69(4):162-164)
AU  - Sheikh A
AU  - Horowitz AM
Y1  - 1999/10//
N1  - Accession Number: 107102959. Language: English. Entry Date: 20000401. Revision Date: 20150820. Publication Type: Journal Article; commentary; letter; response. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0376370. 
KW  - Dental Caries -- Prevention and Control -- In Infancy and Childhood
KW  - Oral Hygiene -- Education -- In Infancy and Childhood
KW  - Fluorides -- Therapeutic Use -- In Infancy and Childhood
KW  - Dentifrices -- Therapeutic Use -- In Infancy and Childhood
KW  - Dental Health Education -- In Infancy and Childhood
KW  - Poverty
KW  - Developing Countries
KW  - Child
SP  - 299
EP  - 300
JO  - Journal of School Health
JF  - Journal of School Health
JA  - J SCH HEALTH
VL  - 69
IS  - 8
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
SN  - 0022-4391
AD  - Health Specialist, National Institutes of Health, National Institute of Dental and Craniofacial Research, Bldg. 45, Room 3-AN-44, Bethesda, MD 20892-6401
U2  - PMID: 10544361.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107102959&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107104756
T1  - Toward 'molecular gastronomy,' or what's in a taste?
AU  - Slavkin HC
Y1  - 1999/10//
N1  - Accession Number: 107104756. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Receptors, Cell Surface
KW  - Taste Buds -- Physiology
KW  - Taste -- Physiology
KW  - Genetics
KW  - RNA
KW  - Information Resources
SP  - 1497
EP  - 1500
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 10
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, Md. 20892-2290
U2  - PMID: 10570598.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107104756&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107131719
T1  - Once-weekly resistance exercise improves muscle strength and neuromuscular performance in older adults.
AU  - Taaffe DR
AU  - Duret C
AU  - Wheeler S
AU  - Marcus R
Y1  - 1999/10//10/ 1/1999
N1  - Accession Number: 107131719. Language: English. Entry Date: 20000901. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062. 
KW  - Muscle Strengthening -- In Old Age
KW  - Muscle Strength -- In Old Age
KW  - Adaptation, Physiological -- In Old Age
KW  - Neuromuscular Control -- In Old Age
KW  - Time Factors
KW  - Balance, Postural -- In Old Age
KW  - Bone Density -- In Old Age
KW  - Male
KW  - Female
KW  - Aged
KW  - California
KW  - Random Assignment
KW  - Intervention Trials
KW  - Exercise Intensity -- In Old Age
KW  - Community Living -- In Old Age
KW  - Exercise Test, Muscular -- In Old Age
KW  - Absorptiometry, Photon -- In Old Age
KW  - Rising -- In Old Age
KW  - Walking -- In Old Age
KW  - Weight Lifting -- In Old Age
KW  - Data Analysis Software
KW  - Analysis of Variance
KW  - Analysis of Covariance
KW  - Fisher's Exact Test
KW  - Unpaired T-Tests
KW  - Two-Tailed Test
KW  - Descriptive Statistics
KW  - Power Analysis
KW  - Body Weights and Measures -- In Old Age
KW  - Human
SP  - 1208
EP  - 1214
JO  - Journal of the American Geriatrics Society
JF  - Journal of the American Geriatrics Society
JA  - J AM GERIATR SOC
CY  - Malden, Massachusetts
PB  - Wiley-Blackwell
AB  - OBJECTIVE: To determine the effect of frequency of resistive training on gain in muscle strength and neuromuscular performance in healthy older adults. DESIGN: A randomized controlled trial with subjects assigned either to high-intensity resistance training 1 (EX1), 2 (EX2), or 3 (EX3) days per week for 24 weeks or to a control group (CO). SETTING: An exercise facility at an academic medical center. SUBJECTS: Forty-six community-dwelling healthy men (n = 29) and women (n = 17) aged 65 to 79 years. INTERVENTION: Progressive resistance training consisting of three sets of eight exercises targeting major muscle groups of the upper and lower body, at 80% of one-repetition maximum (1-RM) for eight repetitions, either 1, 2, or 3 days per week. MEASURES: Dynamic muscle strength (1-RM) using isotonic equipment every 4 weeks, bone mineral density and body composition by dual energy X-ray absorptiometry (DXA), and neuromuscular performance by timed chair rise and 6-meter backward tandem walk. RESULTS: For each of the eight exercises, muscle strength increased in the exercise groups relative to CO (P < .01), with no difference among EX1, EX2 and EX3 groups at any measurement interval. Percent change averaged 3.9 +/- 2.4 (CO), 37.0 +/- 15.2 (EX1), 41.9 +/- 18.2 (EX2), and 39.7 +/- 9.8 (EX3). The time to rise successfully from the chair 5 times decreased significantly (P < .01) at 24 weeks, whereas improvement in the 6-meter backward tandem walk approached significance (P = .10) in the three exercise groups compared with CO. Changes in chair rise ability were correlated to percent changes in quadriceps strength (r = -0.40, P < .01) and lean mass (r = -0.40, P < .01). CONCLUSIONS: A program of once or twice weekly resistance exercise achieves muscle strength gains similar to 3 days per week training in older adults and is associated with improved neuromuscular performance. Such improvement could potentially reduce the risk of falls and fracture in older adults.
SN  - 0002-8614
AD  - National Institute on Aging, Epidemiology, Demography, and Biometry Program, Gateway Bldg, 7201 Wisconsin Ave, Suite 3C-309, Bethesda, MD 20892-9205
U2  - PMID: 10522954.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107131719&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107102995
T1  - Low back pain and disability in older women: independent association with difficulty but not inability to perform daily activities.
AU  - Leveille SG
AU  - Guralnik JM
AU  - Hochberg M
AU  - Hirsch R
AU  - Ferrucci L
AU  - Langlois J
AU  - Rantanen T
AU  - Ling S
Y1  - 1999/10//
N1  - Accession Number: 107102995. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al); Geriatric Depression Scale. NLM UID: 9502837. 
KW  - Low Back Pain -- Epidemiology -- In Old Age
KW  - Activities of Daily Living -- In Old Age
KW  - Disability Evaluation -- In Old Age
KW  - Prospective Studies
KW  - Geriatric Functional Assessment
KW  - Research Instruments
KW  - Interviews
KW  - Questionnaires
KW  - Exercise Test, Muscular -- In Old Age
KW  - Neuropsychological Tests
KW  - Chi Square Test
KW  - Descriptive Statistics
KW  - T-Tests
KW  - Logistic Regression
KW  - Data Analysis, Statistical
KW  - Data Analysis Software
KW  - Odds Ratio
KW  - Confidence Intervals
KW  - P-Value
KW  - Osteoarthritis -- Epidemiology -- In Old Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Female
KW  - Human
SP  - M487
EP  - 93
JO  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF  - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JA  - J GERONTOL A BIOL SCI MED SCI
VL  - 54A
IS  - 10
PB  - Oxford University Press / USA
SN  - 1079-5006
AD  - National Institute on Aging, Gateway Building, Suite 3C-309, 7201 Wisconsin Ave., Bethesda, MD 20892; e-mail: leveills@exmur.nia.nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107102995&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Gerber, M. A.;
AU  - Tanz, R. R.;
AU  - Kabat, W.;
AU  - Bell, G. L.;
AU  - Shulman, S. T.;
AU  - \ET/;
T1  - Potential mechanisms for failure to eradicate group A streptococci from the pharynx
CT  - Potential mechanisms for failure to eradicate group A streptococci from the pharynx
JO  - Pediatrics (USA)
JF  - Pediatrics (USA)
Y1  - 1999/10/01/
VL  - 104
IS  - Oct
SP  - 911
EP  - 917
SN  - 00314005
AD  - Dept. of Pediatr., Univ. of Connecticut Sch. of Med., Connecticut Children's Med. Ctr., Hartford, CT, USA Reprints: NIAID/DMID/CRAB, Rm. 3104, 6700-B Rockledge Dr., Bethesda, MD 20892-7630, USA Internet: mg289d@nih.gov
N1  - Accession Number: 38-00670; Language: English; Trade Name: Cefadroxil monohydrate; Generic Name: Cefadroxil; Chemical Name: Cefadroxil--66592-87-8 Cefadroxil--66592-87-8 Penicillin V--87-08-1 Penicillin V--87-08-1; References: 40; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: M. Therese Gyi
N2  - To investigate the relative efficacy of oral cefadroxil (cefadroxil monohydrate) and penicillin V in the treatment of group A streptococcal (GABHS) pharyngitis, a randomized study was conducted in 462 pediatric patients who received cefadroxil 30 mg/kg daily (maximum of 1000 mg/day) or penicillin V 25 to 50 mg/kg daily (maximum of 1000 mg/day) for 10 days. The bacteriologic outcome was evaluable and compliance was confirmed in 374 of the patients (187 cefadroxil; 187 penicillin). Bacteriologic treatment success rates for patients in the cefadroxil and penicillin groups were 94% and 86%, respectively. Among patients likely to have GABHS pharyngitis, there was no difference in treatment success rates in drug groups. In patients likely to be streptococcal carriers, treatment success rates in the cefadroxil and penicillin groups were 92% and 73%, respectively. The presence of \b/-lactamase or bacteriocin producing pharyngeal flora had no consistent effect on bacteriologic eradication rates among patients in either drug treatment group or in patients having GABHS pharyngitis or streptococcal carriage.
KW  - Cefadroxil--streptococcal infections-;
KW  - Penicillin V--streptococcal infections-;
KW  - Streptococcal infections--cefadroxil--comparisons;
KW  - Streptococcal infections--penicillin V--comparisons;
KW  - Pharyngitis--cefadroxil--comparisons;
KW  - Pharyngitis--penicillin V--comparisons;
KW  - Drug comparisons--cefadroxil and penicillin V--S. pyogenes pharyngitis;
KW  - Drug comparisons--penicillin V and cefadroxil--S. pyogenes pharyngitis;
KW  - Pediatrics--streptococcal infections--cefadroxil-penicillin V comparisons;
KW  - Cephalosporins--cefadroxil--comparisons;
KW  - Penicillins--penicillin V--comparisons;
KW  - Mechanism of action--cefadroxil--streptococcal infections;
KW  - Mechanism of action--penicillin--streptococcal infections;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=38-00670&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
ID  - 107231052
T1  - Nursing's holistic impact.
AU  - Varricchio C
Y1  - 1999///1999 4th Quarter
N1  - Accession Number: 107231052. Language: English. Entry Date: 19991201. Revision Date: 20150820. Publication Type: Journal Article. Supplement Title: 1999 4th Quarter. Journal Subset: Nursing; USA. NLM UID: 9302919. 
KW  - Holistic Care
KW  - Research, Nursing
KW  - Breast Neoplasms
KW  - Prostatic Neoplasms
KW  - Patient Centered Care
SP  - 10
EP  - 45
JO  - Reflections (08858144)
JF  - Reflections (08858144)
JA  - REFLECTIONS
VL  - 25
IS  - 4
CY  - Indianapolis, Indiana
PB  - Sigma Theta Tau International
SN  - 0885-8144
AD  - National Cancer Institute Division of Cancer Prevention, Bethesda, Md
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107231052&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
T1  - CARDIOVASCULAR REACTIVITY TO SIMULATED SOCIAL STRESS.
AU  - Lipp, Marilda N.
AU  - Anderson, David E.
JO  - Stress Medicine
JF  - Stress Medicine
Y1  - 1999/10//
VL  - 15
IS  - 4
SP  - 249
EP  - 257
SN  - 07488386
N1  - Accession Number: 17063486; Author: Lipp, Marilda N.: 1 Author: Anderson, David E.: 2 ; Author Affiliation: 1 Catholic University of Campinas, Campinas, Sao Paolo, Brazil.: 2 Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, MD, USA.; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20050519
N2  - This study tested the hypotheses that blood pressure reactivity to simulated social stress would be positively correlated with resting pCO2 and with increased variability of blood pressure in the natural environment. Sixty white and black men and women participated in a role-playing task involving scenarios describing common infringements of their rights. Blood pressure was higher during the role playing task than during a preceding structured interview and an intervening rest period, and decreased after role playing. Heart rate changes were small by comparison, though heart rate reactivity of women was greater than that of men. Blood pressure reactivity was not correlated with resting pCO2 and was inversely correlated with ambulatory systolic blood pressure variability. Resting pCO2 was, however, correlated with mean 24-h ambulatory systolic and diastolic blood pressure. This study confirms that social stress elevated blood pressure acutely via a vascular mechanism, is consistent with the view that hyperresponsive individuals tend to avoid arousing situations, and further implicates pCO2 in long-term blood pressure regulation. ABSTRACT FROM AUTHOR
KW  - *BLOOD pressure
KW  - *HYPERTENSION
KW  - *MEDICAL care
KW  - *BLOOD
KW  - *BLOOD circulation disorders
KW  - AFRICAN American women
KW  - blood pressure
KW  - heart rate
KW  - hypertension
KW  - pCO2
KW  - reactivity
KW  - social stress
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=17063486&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - s3h
ER  - 

TY  - JOUR
ID  - 2006-00313-001
AN  - 2006-00313-001
AU  - Simon, Tony J.
T1  - The foundations of numerical thinking in a brain without numbers.
JF  - Trends in Cognitive Sciences
JO  - Trends in Cognitive Sciences
JA  - Trends Cogn Sci
Y1  - 1999/10//
VL  - 3
IS  - 10
SP  - 363
EP  - 365
CY  - Netherlands
PB  - Elsevier Science
SN  - 1364-6613
AD  - Simon, Tony J., Neuroscience Center, National Institute on Drug Abuse, NIH, Bethesda, MD, US, 20893
N1  - Accession Number: 2006-00313-001. PMID: 10498924 Partial author list: First Author & Affiliation: Simon, Tony J.; Neuroscience Center, National Institute on Drug Abuse, NIH, Bethesda, MD, US. Release Date: 20060417. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Intuition; Language; Mathematical Ability; Spatial Perception; Visual Perception. Minor Descriptor: Bilingualism; Competence. Classification: Human Experimental Psychology (2300). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1999. 
AB  - Comments on an article by S. Dehaene et al. (see record [rid]1999-05057-002[/rid]). Authors investigated the cognitive and neural bases of mathematical thinking, the key findings of which were summarized by Butterworth as indicating that 'mathematical ability... results from the integration of two non-numerical neural circuits in the brain'. Their findings are compelling and provocative and they provide further support for the view that humans have at least two means of representing and processing quantity. Authors have presented data that provide strong new evidence for the dichotomy between perceptually and conceptually based quantitative competence. However, the findings pose new questions about which common cultural experiences are necessary to stimulate our brains to organize themselves in such a way as to add these, initially unspecified, functional capabilities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - linguistic competence
KW  - visiospatial representation
KW  - mathematical intution
KW  - bilingualism
KW  - 1999
KW  - Intuition
KW  - Language
KW  - Mathematical Ability
KW  - Spatial Perception
KW  - Visual Perception
KW  - Bilingualism
KW  - Competence
KW  - 1999
DO  - 10.1016/S1364-6613(99)01383-2
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00313-001&site=ehost-live&scope=site
UR  - tjsimon@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-16643-004
AN  - 2011-16643-004
AU  - Hyman, Steven E.
T1  - Selective gene expression increases behavioral sensitivity to cocaine.
JF  - Nature Neuroscience
JO  - Nature Neuroscience
JA  - Nat Neurosci
Y1  - 1999/10//
VL  - 2
IS  - 10
SP  - 855
EP  - 856
CY  - United Kingdom
PB  - Nature Publishing Group
SN  - 1097-6256
SN  - 1546-1726
AD  - Hyman, Steven E., National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, MD, US, 20892-9669
N1  - Accession Number: 2011-16643-004. PMID: 10491599 Partial author list: First Author & Affiliation: Hyman, Steven E.; National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Cocaine; Drug Sensitivity; Gene Expression; Homeostasis. Minor Descriptor: Antigens. Classification: Psychopharmacology (2580). Population: Animal (20). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 1999. Copyright Statement: Nature America Inc. 1999. 
AB  - Comments on an article M. B. Kelz et al. The authors reported an interesting transgenic mouse in which a transcription factor known to be induced by cocaine, ΔfosB, is expressed postnatally in appropriate cell types under reasonable temporal control. Addiction can be conceptualized as compulsive drug use despite negative consequences. The course of addiction is usually chronic, with periods of active drug use followed by periods of hard-won abstinence, most often followed by relapse. At first glance, the problem of creating animal models to investigate the pathophysiology of addiction would appear quite tractable. With this background, we can put the work of the authors in perspective. The Fos family of transcription factors includes cFos, Fos-related antigens (FRAs) 1 and 2 and Fos B, which also has a truncated splice form, ΔFosB. The results of these studies are surprising and interesting because ΔFosB was initially thought to represent a homeostatic response to cocaine. Indeed, the isoforms of ΔfosB that were studied bythe authors were initially interesting precisely because of their prolonged upregulation by cocaine. This paper also whets our intellectual appetites for additional lines of mice expressing additional drug-inducible genes with steadily improving spatial and temporal control. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - selective gene expression
KW  - behavioral sensitivity
KW  - cocaine
KW  - antigens
KW  - homeostasis
KW  - 1999
KW  - Cocaine
KW  - Drug Sensitivity
KW  - Gene Expression
KW  - Homeostasis
KW  - Antigens
KW  - 1999
DO  - 10.1038/13147
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16643-004&site=ehost-live&scope=site
UR  - shyman@nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-16643-005
AN  - 2011-16643-005
AU  - Oram, Mike W.
AU  - Richmond, Barry J.
T1  - I see a face—a happy face.
JF  - Nature Neuroscience
JO  - Nature Neuroscience
JA  - Nat Neurosci
Y1  - 1999/10//
VL  - 2
IS  - 10
SP  - 856
EP  - 858
CY  - United Kingdom
PB  - Nature Publishing Group
SN  - 1097-6256
SN  - 1546-1726
AD  - Oram, Mike W., School of Psychology, University of St. Andrews, Fife, United Kingdom, KY16 9JU
N1  - Accession Number: 2011-16643-005. PMID: 10491600 Partial author list: First Author & Affiliation: Oram, Mike W.; School of Psychology, University of St. Andrews, Fife, United Kingdom. Release Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Facial Expressions; Neurons; Temporal Lobe; Behavioral Neuroscience. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1999. Copyright Statement: Nature America Inc. 1999. 
AB  - Comments on an article by Y. Sugase et al. The authors recorded the responses of single neurons in the inferior temporal cortex while the monkeys viewed pictures of colored shapes, human faces or monkey faces. The faces were from different individuals, and the face of any individual could show different expressions. This allowed the authors to examine the degree to which a neuron was signaling information at different levels of discrimination: face versus non-face, monkey versus human, individual identities and different facial expressions. The idea that individual sensory neurons can carry information about different stimulus attributes is not new. To understand the significance of the new findings, it is helpful to consider some of the previous studies examining the information content of neural responses. The findings of Sugase and colleagues might seem more akin to the phenomenon of behavioral modulation, in which top-down information about behavioral significance of a stimulus causes the response to evolve over time. As with any innovative and exciting study, the findings of Sugase and colleagues raise more questions than they answer. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurons
KW  - facial expressions
KW  - behavioral modulation
KW  - temporal cortex
KW  - 1999
KW  - Facial Expressions
KW  - Neurons
KW  - Temporal Lobe
KW  - Behavioral Neuroscience
KW  - 1999
DO  - 10.1038/13149
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16643-005&site=ehost-live&scope=site
UR  - bjr@ln.nimh.nih.gov
UR  - mwo@st-andrews.ac.uk
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-16643-008
AN  - 2011-16643-008
AU  - Giedd, Jay N.
AU  - Blumenthal, Jonathan
AU  - Jeffries, Neal O.
AU  - Castellanos, F. X.
AU  - Liu, Hong
AU  - Zijdenbos, Alex
AU  - Paus, Tomáš
AU  - Evans, Alan C.
AU  - Rapoport, Judith L.
T1  - Brain development during childhood and adolescence: A longitudinal MRI study.
JF  - Nature Neuroscience
JO  - Nature Neuroscience
JA  - Nat Neurosci
Y1  - 1999/10//
VL  - 2
IS  - 10
SP  - 861
EP  - 863
CY  - United Kingdom
PB  - Nature Publishing Group
SN  - 1097-6256
SN  - 1546-1726
AD  - Giedd, Jay N., Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 4C110, 10 Center Drive, MSC 1367, Bethesda, MD, US, 20892
N1  - Accession Number: 2011-16643-008. PMID: 10491603 Partial author list: First Author & Affiliation: Giedd, Jay N.; Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Brain Development; Pediatrics. Minor Descriptor: Childhood Development; Neuroimaging; Gray Matter; White Matter. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Methodology: Brain Imaging; Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1999. Publication History: Accepted Date: Aug 9, 1999; First Submitted Date: May 21, 1999. Copyright Statement: Nature America Inc. 1999. 
AB  - In this large-scale longitudinal pediatric neuroimaging study, we confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a post-adolescent decrease. The subjects for this study were healthy boys and girls participating in an ongoing longitudinal pediatric brain-MRI project at the Child Psychiatry Branch at the National Institute of Mental Health. Volumes of white and cortical gray matter were quantitatively analyzed by combining a technique using an artificial neural network to classify tissues based on voxel intensity with non-linear registration to a template brain for which these tissue regions had been manually defined. We used previously described statistical analysis techniques that combine cross-sectional and longitudinal data. This MRI study demonstrates a pre-adolescent increase in cortical gray matter; this phenomenon was previously obscured, probably by the lack of longitudinal data, as even in an analysis of the 145 cross-sectional data points in our sample, the largest to date, we could not detect nonlinearity in these developmental curves. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - brain development
KW  - childhood development
KW  - adolescence development
KW  - neuroimaging
KW  - white matter
KW  - gray matter
KW  - pediatrics
KW  - 1999
KW  - Adolescent Development
KW  - Brain Development
KW  - Pediatrics
KW  - Childhood Development
KW  - Neuroimaging
KW  - Gray Matter
KW  - White Matter
KW  - 1999
DO  - 10.1038/13158
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16643-008&site=ehost-live&scope=site
UR  - ORCID: 0000-0001-9192-9437
UR  - 
UR  - jgiedd@helix.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-16643-015
AN  - 2011-16643-015
AU  - Cameron, Heather A.
AU  - McKay, Ronald D. G.
T1  - Restoring production of hippocampal neurons in old age.
JF  - Nature Neuroscience
JO  - Nature Neuroscience
JA  - Nat Neurosci
Y1  - 1999/10//
VL  - 2
IS  - 10
SP  - 894
EP  - 897
CY  - United Kingdom
PB  - Nature Publishing Group
SN  - 1097-6256
SN  - 1546-1726
AD  - Cameron, Heather A., Laboratory of Molecular Biology, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US, 20892
N1  - Accession Number: 2011-16643-015. PMID: 10491610 Partial author list: First Author & Affiliation: Cameron, Heather A.; Laboratory of Molecular Biology, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Corticosteroids; Hippocampus; Neurons; Cell Proliferation. Minor Descriptor: Neurogenesis. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Oct, 1999. Publication History: First Posted Date: Aug 11, 1999. Copyright Statement: Nature America Inc. 1999. 
AB  - The production of hippocampal granule neurons continues throughout adulthood but dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons. This result indicates that the neuronal precursor population in the dentate gyrus remains stable into old age, but that neurogenesis is normally slowed by high levels of corticosteroids. The findings further suggest that decreased neurogenesis may contribute to age-related memory deficits associated with high corticosteroids, and that these deficits may be reversible. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - hippocampal neurons
KW  - old age
KW  - neurons
KW  - corticosteroids
KW  - cell proliferation
KW  - 1999
KW  - Aging
KW  - Corticosteroids
KW  - Hippocampus
KW  - Neurons
KW  - Cell Proliferation
KW  - Neurogenesis
KW  - 1999
DO  - 10.1038/13197
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16643-015&site=ehost-live&scope=site
UR  - 
UR  - ORCID: 0000-0002-3245-5777
UR  - cameron@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-16643-017
AN  - 2011-16643-017
AU  - Gottlieb, Jacqueline
AU  - Goldberg, Michael E.
T1  - Activity of neurons in the lateral intraparietal area of the monkey during an antisaccade task.
JF  - Nature Neuroscience
JO  - Nature Neuroscience
JA  - Nat Neurosci
Y1  - 1999/10//
VL  - 2
IS  - 10
SP  - 906
EP  - 912
CY  - United Kingdom
PB  - Nature Publishing Group
SN  - 1097-6256
SN  - 1546-1726
AD  - Gottlieb, Jacqueline, Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, US, 20892
N1  - Accession Number: 2011-16643-017. PMID: 10491612 Partial author list: First Author & Affiliation: Gottlieb, Jacqueline; Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, US. Release Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Eye Movements; Neurons; Parietal Lobe; Vision. Minor Descriptor: Monkeys. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 1999. Publication History: Accepted Date: Aug 24, 1999; First Submitted Date: May 4, 1999. Copyright Statement: Nature America Inc. 1999. 
AB  - The close relationship between saccadic eye movements and vision complicates the identification of neural responses associated with each function. Visual and saccade-related responses are especially closely intertwined in a subdivision of posterior parietal cortex, the lateral parietal area (LIP). We analyzed LIP neurons using an antisaccade task in which monkeys made saccades away from a salient visual cue. The vast majority of neurons reliably signaled the location of the visual cue. In contrast, most neurons had only weak, if any, saccade-related activity independent of visual stimulation. Thus, whereas the great majority of LIP neurons reliably encoded cue location, only a small minority encoded the direction of the upcoming saccade. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurons
KW  - lateral intraparietal area
KW  - monkeys
KW  - antisaccade tasks
KW  - eye movements
KW  - parietal cortex
KW  - 1999
KW  - Eye Movements
KW  - Neurons
KW  - Parietal Lobe
KW  - Vision
KW  - Monkeys
KW  - 1999
DO  - 10.1038/13209
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16643-017&site=ehost-live&scope=site
UR  - jgb@lsr.nei.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2011-16643-018
AN  - 2011-16643-018
AU  - Chao, Linda L.
AU  - Haxby, James V.
AU  - Martin, Alex
T1  - Attribute-based neural substrates in temporal cortex for perceiving and knowing about objects.
JF  - Nature Neuroscience
JO  - Nature Neuroscience
JA  - Nat Neurosci
Y1  - 1999/10//
VL  - 2
IS  - 10
SP  - 913
EP  - 919
CY  - United Kingdom
PB  - Nature Publishing Group
SN  - 1097-6256
SN  - 1546-1726
AD  - Martin, Alex, Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 4C104, Bethesda, MD, US, 20892-1366
N1  - Accession Number: 2011-16643-018. PMID: 10491613 Partial author list: First Author & Affiliation: Chao, Linda L.; Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neural Pathways; Temporal Lobe. Minor Descriptor: Animals. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 1999. Publication History: Accepted Date: Aug 11, 1999; Revised Date: May 12, 1999. Copyright Statement: Nature America Inc. 1999. 
AB  - The cognitive and neural mechanisms underlying category-specific knowledge remain controversial. Here we report that, across multiple tasks (viewing, delayed match to sample, naming), pictures of animals and tools were associated with highly consistent, category-related patterns of activation in ventral (fusiform gyrus) and lateral (superior and middle temporal gyri) regions of the posterior temporal lobes. In addition, similar patterns of category-related activity occurred when subjects read the names of, and answered questions about, animals and tools. These findings suggest that semantic object information is represented in distributed networks that include sites for storing information about specific object attributes such as form (ventral temporal cortex) and motion (lateral temporal cortex). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neural substrates
KW  - temporal cortex
KW  - animals
KW  - 1999
KW  - Neural Pathways
KW  - Temporal Lobe
KW  - Animals
KW  - 1999
DO  - 10.1038/13217
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16643-018&site=ehost-live&scope=site
UR  - alex@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43850-013
AN  - 2015-43850-013
AU  - Moore, L. E.
AU  - Chub, N.
AU  - Tabak, J.
AU  - O'Donovan, M.
T1  - NMDA-induced dendritic oscillations during a soma voltage clamp of chick spinal neurons.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/10//
VL  - 19
IS  - 19
SP  - 8271
EP  - 8280
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Moore, L. E., Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, UPRESA-7060, Centre National de la Recherche Scientifique, 45 rue des Saints-Peres, 75270, Paris, France, Cedex 06
N1  - Accession Number: 2015-43850-013. PMID: 10493728 Partial author list: First Author & Affiliation: Moore, L. E.; Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, UPRESA-7060, Paris, France. Release Date: 20160822. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dendrites; N-Methyl-D-Aspartate; Membrane Potentials; Soma (Cells); Oscillatory Network. Minor Descriptor: Chickens; Neural Receptors. Classification: Electrophysiology (2530). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 1999. Publication History: Accepted Date: Jul 20, 1999; Revised Date: Jul 8, 1999; First Submitted Date: Mar 23, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - An investigation of dendritic membrane properties was performed by whole-cell patch measurements of the biophysical properties of intact chick spinal neurons that are involved in rhythmogenesis. A whole-cell voltage clamp of the somatic membrane was used to block NMDA-induced voltage oscillations from the cell body, thus partially isolating the intrinsic oscillatory properties of dendritic membranes from those of the soma. An experimental approach was developed that takes into account the complexity of the dendritic tree in an environment as normal as possible, without the need for cell isolation or slice preparations. A computational study of the experimentally determined model showed that excitatory amino acid receptors on dendrites can dynamically control the electrotonic length of the dendrites through the activation of negative slope conductances. These experiments demonstrate the presence of NMDA receptors on the dendrites and that they induce intrinsic oscillations when the synaptic input from other cells is significantly reduced. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW  - dendritic oscillations
KW  - chick spinal neurons
KW  - NMDA
KW  - electrotonic structure
KW  - frequency domain
KW  - impedance
KW  - 1999
KW  - Dendrites
KW  - N-Methyl-D-Aspartate
KW  - Membrane Potentials
KW  - Soma (Cells)
KW  - Oscillatory Network
KW  - Chickens
KW  - Neural Receptors
KW  - 1999
U1  - Sponsor: Centre national de la recherche scientifique, France. Recipients: No recipient indicated
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-43850-013&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43850-014
AN  - 2015-43850-014
AU  - Cui, Changhai
AU  - Mayer, Mark L.
T1  - Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/10//
VL  - 19
IS  - 19
SP  - 8281
EP  - 8291
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Mayer, Mark L., National Institutes of Health, Building 49, Room 5A78, 49 Convent Drive, Bethesda, MD, US, 20892-4495
N1  - Accession Number: 2015-43850-014. PMID: 10493729 Partial author list: First Author & Affiliation: Cui, Changhai; Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20160822. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Genes; Glutamate Receptors. Minor Descriptor: Mice; Neural Receptors; AMPA. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Oct, 1999. Publication History: Accepted Date: Jul 21, 1999; Revised Date: Jul 19, 1999; First Submitted Date: Jun 2, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - In the CNS kainate subtype glutamate receptors (GluRs) are likely to be heteromeric assemblies containing multiple gene products. However, although recombinant kainate receptors from the GluR5–GluR7 gene family have been studied extensively in their homomeric forms, there have been no tests to determine whether these subunits can coassemble with each other. We used the GluR5 selective agonists (RS)-2-amino-3- (3-hydroxy-5-tertbutylisoxazol-4-yl)propanoic acid (ATPA) and (S)-5-iodowillardiine (I-will) to test for the coassembly of GluR5 with GluR6 and GluR7 by measuring changes in rectification that occur for heteromeric receptors containing both edited and unedited Q/R site subunits. Birectifying ATPA and I-will responses resulting from polyamine block for homomeric GluR5(Q) became outwardly rectifying when GluR6(R) was coexpressed with GluR5(Q), although GluR6 was not activated by ATPA or I-will, indicating the formation of heteromeric receptors. Similar approaches showed the coassembly of GluR7 with GluR6 and GluR5. Heteromeric kainate receptors containing both GluR5 and GluR6 subunits exhibited novel functional properties, including reduced desensitization and faster recovery from desensitization than those recorded for homomeric GluR5. Coexpression of GluR6 with GluR5 also enhanced the magnitude of responses to GluR5 selective agonists. In contrast, the coassembly of GluR7 with GluR6 markedly decreased the amplitude of agonist responses. Our results indicate that, similar to AMPA receptors, the kainate receptor subunits GluR5–GluR7 exhibit promiscuous coassembly. The formation of heteromeric kainate receptors may help to explain why the functional properties of native kainate receptors differ from those that have been reported for recombinant kainate receptors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - kainate receptors
KW  - polyamines
KW  - glutamate receptors
KW  - ATPA
KW  - iodowillardiine
KW  - coassembly
KW  - heteromeric glutamate receptors
KW  - 1999
KW  - Central Nervous System
KW  - Genes
KW  - Glutamate Receptors
KW  - Mice
KW  - Neural Receptors
KW  - AMPA
KW  - 1999
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-43850-014&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43850-046
AN  - 2015-43850-046
AU  - Wang, Hao
AU  - Copeland, Neal G.
AU  - Gilbert, Debra J.
AU  - Jenkins, Nancy A.
AU  - Tessier-Lavigne, Marc
T1  - 'Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors': Correction.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/10//
VL  - 19
IS  - 19
SP  - 8720
EP  - 8720
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Tessier-Lavigne, Marc, Department of Anatomy, University of California, 513 Parnassus Avenue, Room S-1479, San Francisco, CA, US, 94143-0452
N1  - Accession Number: 2015-43850-046. Partial author list: First Author & Affiliation: Wang, Hao; Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA, US. Release Date: 20160822. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Ganglia; Genes; Peripheral Nervous System; Sensory Neurons. Minor Descriptor: Axons; Chromosomes; Mice. Classification: Neuropsychology & Neurology (2520). Page Count: 1. Issue Publication Date: Oct, 1999. 
AB  - Reports an error in 'Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors' by Hao Wang, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins and Marc Tessier-Lavigne (The Journal of Neuroscience, 1999[Jun], Vol 19[12], 4938-4947). In the original article, on page 4939, in Figure 1, 'mouse netrin-2' should read 'mouse netrin-3.' In Figure 1 legend, 'GenBank accession number: AF152418' should be added at the end of the legend. In the first sentences on page 4944 and in Figure 9 legend on page 4946, ' 120 μ/ml' should read ' 120 ng/ml.' (The following abstract of the original article appeared in record [rid]2015-42600-028[/rid]). The netrins comprise a small phylogenetically conserved family of guidance cues important for guiding particular axonal growth cones to their targets. Two netrin genes, netrin-1 and netrin-2, have been described in chicken, but in mouse so far a single netrin gene, an ortholog of chick netrin-1, has been reported. We report the identification of a second mouse netrin gene, which we name netrin-3. Netrin-3 does not appear to be the ortholog of chick netrin-2 but is the ortholog of a recently identified human netrin gene termed NTN2L ('netrin-2-like'), as evidenced by a high degree of sequence conservation and by chromosomal localization. Netrin-3 is expressed in sensory ganglia, mesenchymal cells, and muscles during the time of peripheral nerve development but is largely excluded from the CNS at early stages of its development. The murine netrin-3 protein binds to netrin receptors of the DCC (deleted in colorectal cancer) family [DCC and neogenin] and the UNC5 family (UNC5H1, UNC5H2 and UNC5H3). Unlike chick netrin-1, however, murine netrin-3 binds to DCC with lower affinity than to the other four receptors. Consistent with this finding, although murine netrin-3 can mimic the outgrowth-promoting activity of netrin-1 on commissural axons, it has lower specific activity than netrin-1. Thus, like netrin-1, netrin-3 may also function in axon guidance during development but may function predominantly in the development of the peripheral nervous system and may act primarily through netrin receptors other than DCC. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - netrin-3
KW  - axon guidance
KW  - sensory neurons
KW  - mouse chromosome 17
KW  - peripheral nervous system
KW  - DCC
KW  - 1999
KW  - Ganglia
KW  - Genes
KW  - Peripheral Nervous System
KW  - Sensory Neurons
KW  - Axons
KW  - Chromosomes
KW  - Mice
KW  - 1999
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-43850-046&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 107089404
T1  - Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood...including commentary by Singer HS
AU  - Perlmutter SJ
AU  - Leitman SF
AU  - Garvey MA
AU  - Hamburger S
AU  - Feldman E
AU  - Leonard HL
AU  - Swedo SE
Y1  - 1999/10/02/
N1  - Accession Number: 107089404. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; commentary; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Instrumentation: Global Assessment Scale; Structured Psychiatric Interview; Yale-Brown Obsessive Compulsive Scale; Tourette Syndrome Unified Rating Scale; Clinical Global Impression Scales of Symptom Severity and Change; National Institute of Mental Health Rating Scales for Global Functioning, Anxiety, and Depression; National Institute of Mental Health Emotional Liability Scale. NLM UID: 2985213R. 
KW  - Obsessive-Compulsive Disorder -- Therapy
KW  - Plasma Exchange
KW  - Movement Disorders -- Therapy
KW  - Immunoglobulins, Intravenous -- Therapeutic Use
KW  - Streptococcal Infections -- Complications
KW  - Obsessive-Compulsive Disorder -- Etiology
KW  - Movement Disorders -- Etiology
KW  - Treatment Outcomes
KW  - Neuropsychological Tests
KW  - Analysis of Variance
KW  - Chi Square Test
KW  - T-Tests
KW  - Pearson's Correlation Coefficient
KW  - Adolescence
KW  - Clinical Trials
KW  - Child
KW  - Child, Preschool
KW  - Male
KW  - Female
KW  - Human
SP  - 1153
EP  - 1138
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 354 North American Edition
IS  - 9185
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Pediatrics and Developmental Neuropsychiatry Branch, National Institutes of Health, Bethesda, MD 20892
U2  - PMID: 10513708.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107089404&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107086563
T1  - Introduction...proceedings of the fourth annual Ross Medical Nutrition and Device Roundtable, Charleston, SC, April 26-28, 1999
AU  - Sonies BC
Y1  - 1999/10/02/1999 Oct Suppl
N1  - Accession Number: 107086563. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 1999 Oct Suppl. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8606733. 
KW  - Deglutition Disorders
KW  - Serial Publications
SP  - S1
EP  - S1
JO  - Nutrition in Clinical Practice
JF  - Nutrition in Clinical Practice
JA  - NUTR CLIN PRACT
VL  - 14
IS  - 5
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0884-5336
AD  - Speech-Language Pathology Section and Oral Pharyngeal Imaging Laboratory, National Institutes of Health, Bethesda, MD
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107086563&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107086588
T1  - Current research trends in dysphagia and dysphagia management...proceedings of the fourth annual Ross Medical Nutrition and Device Roundtable, Charleston, SC, April 26-28, 1999
AU  - Sonies BC
Y1  - 1999/10/02/1999 Oct Suppl
N1  - Accession Number: 107086588. Language: English. Entry Date: 20000201. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Supplement Title: 1999 Oct Suppl. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8606733. 
KW  - Swallowing Therapy
KW  - Deglutition Disorders -- Trends
KW  - Research
KW  - Research Support
KW  - Research Priorities
SP  - S66
EP  - 73
JO  - Nutrition in Clinical Practice
JF  - Nutrition in Clinical Practice
JA  - NUTR CLIN PRACT
VL  - 14
IS  - 5
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0884-5336
AD  - Speech-Language Pathology Section, Clinical Center-Room 6S 235, National Institutes of Health, Bethesda, MD 20892; e-mail: barbara_sonies@nih.gov
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107086588&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Rosenthal, Joshua P.
AU  - Beck, DeAndra
AU  - Bhat, Amar
AU  - Biswas, Jamie
AU  - Brady, Linda
AU  - Bridbord, Kenneth
AU  - Collins, Scott
AU  - Cragg, Gordon
AU  - Edwards, James
AU  - Fairfield, Alexandra
AU  - Gottlieb, Michael
AU  - Gschwind, Lee Ann
AU  - Hallock, Yali
AU  - Hawks, Richard
AU  - Hegyeli, Ruth
AU  - Johnson, George
AU  - Keusch, Gerald T.
AU  - Lyons, Elizabeth E.
AU  - Miller, Richard
AU  - Rodman, James
T1  - Combining High Risk Science With Ambitious Social And Economic Goals.
JO  - Pharmaceutical Biology
JF  - Pharmaceutical Biology
Y1  - 1999/10/02/Oct99 Supplement
VL  - 37
M3  - Article
SP  - 6
EP  - 21
PB  - Taylor & Francis Ltd
SN  - 13880209
AB  - Great strides have been made during the past decade in understanding the interelatedness of human health, economic welfare and environmental quality. Among these is the certainty that improvements in health may be impeded or reversed by poverty and destruction of the natural resources that diverse biological species provide. The International Cooperative Biodiversity Groups (ICBG) represent an experimental effort supported by three agencies of the U.S. Government to integrate research in natural products drug discovery with efforts to build the scientific and economic capacity of developing countries as well as enhance the skills and incentives needed to conserve biological diversity. These groups are unique, public-private collaborations that have been carrying out interdisciplinary research and development projects for up to seven years in 12 countries in Latin America, Africa and Asia. In addition to research on species in 230 plant families and 25 arthropod orders, over 1400 individuals have received technical training, and potential therapies for several parasitic diseases, tuberculosis and crop diseases are in development. The ICBGs have also developed novel research and intellectual property agreements and have become important testing grounds in national and global discussions regarding access, informed consent and benefit-sharing associated with genetic resources. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Pharmaceutical Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DRUG development
KW  - ECONOMIC development
KW  - BIODIVERSITY conservation
KW  - biodiversity conservation
KW  - Drug discovery
KW  - economic development
KW  - natural products
KW  - patents
KW  - research
KW  - traditional knowledge
KW  - training
N1  - Accession Number: 6196481; Rosenthal, Joshua P. 1 Beck, DeAndra 2 Bhat, Amar 1 Biswas, Jamie 3 Brady, Linda 4 Bridbord, Kenneth 1 Collins, Scott 5 Cragg, Gordon 6 Edwards, James 5 Fairfield, Alexandra 7 Gottlieb, Michael 7 Gschwind, Lee Ann 1 Hallock, Yali 6 Hawks, Richard 7 Hegyeli, Ruth 8 Johnson, George 6 Keusch, Gerald T. 1 Lyons, Elizabeth E. 5 Miller, Richard 1 Rodman, James 5; Affiliation:  1: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892-2220, USA  2: Foreign Agricultural Service, U.S. Department of Agriculture, Washington, DC 20250-4300, USA  3: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9561, USA  4: National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-9663, USA  5: Biosciences Directorate, National Science Foundation, Arlington, VA 22230, USA  6: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  7: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA  8: National Heart, Lung and Blood Institute, National Institutes of Health,, Bethesda, MD 20892, USA; Source Info: Oct99 Supplement, Vol. 37, p6; Subject Term: DRUG development; Subject Term: ECONOMIC development; Subject Term: BIODIVERSITY conservation; Author-Supplied Keyword: biodiversity conservation; Author-Supplied Keyword: Drug discovery; Author-Supplied Keyword: economic development; Author-Supplied Keyword: natural products; Author-Supplied Keyword: patents; Author-Supplied Keyword: research; Author-Supplied Keyword: traditional knowledge; Author-Supplied Keyword: training; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 16p; Document Type: Article; Full Text Word Count: 10084
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107097836
T1  - Science-based views of drug addiction and its treatment.
AU  - Leshner AI
AU  - Leshner, A I
Y1  - 1999/10/13/
N1  - Accession Number: 107097836. Language: English. Entry Date: 20000301. Revision Date: 20161112. Publication Type: journal article; review. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160. 
KW  - Substance Dependence -- Therapy
KW  - Substance Dependence
KW  - Drug Rehabilitation Programs
SP  - 1314
EP  - 1316
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
JA  - JAMA
VL  - 282
IS  - 14
CY  - Chicago, Illinois
PB  - American Medical Association
SN  - 0098-7484
AD  - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA
AD  - National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md
U2  - PMID: 10527162.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107097836&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - Calis, K. A.;
AU  - Cullinane, A. M.;
AU  - Horne, M. K.;
T1  - Bioactivity of cryopreserved alteplase solutions
CT  - Bioactivity of cryopreserved alteplase solutions
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
Y1  - 1999/10/15/
VL  - 56
IS  - Oct 15
SP  - 2056
EP  - 2057
SN  - 10792082
AD  - Drug Info. Serv., NIH, Bldg. 10, Rm. 1S-259, 10 Center Dr. (MSC 1196), Bethesda, MD 20892, USA Internet: kcalis@nih.gov
N1  - Accession Number: 36-14165; Language: English; Trade Name: Activase; Generic Name: Alteplase; Chemical Name: Alteplase--105857-23-6 Water for Injection--7732-18-5 Polypropylene--9003-07-0; Therapeutic Class: (20:40); AHFS Class: Thrombolytic agents alteplase; References: 6; Journal Coden: AHSPEK; Section Heading: Drug Stability; Abstract Author: Elvira deC. Weiss
N2  - The bioactivity in vitro of cryopreserved alteplase (Activase) solutions was studied. Alteplase was reconstituted with sterile water for injection to a final concentration of 1 mg/ml and stored in a polypropylene tube at \-/20\DG/C for 6 months. On a separate occasion, alteplase was reconstituted with sterile water for injection to a final concentration of 1 mg/ml in a biological safety cabinet. Three 2 ml portions of this solution were stored in clear glass vials at \-/70\DG/C for 2 wk. These vials were thawed at 37\DG/C for 5 min in a water bath incubator, kept at room temperature (22-24\DG/C) for 24 h, and then refrozen at \-/70\DG/C. All the samples were kept frozen until the day their activity was measured. On the day of the assay, all the samples were thawed at 37\DG/C and kept at 22-24\DG/C. Results showed that the bioactivity of alteplase in all the treatment samples was indistinguishable from that of alteplase in the freshly prepared control solution.
KW  - Alteplase--stability-;
KW  - Water for Injection--diluents-;
KW  - Polypropylene--containers-;
KW  - Stability--alteplase--cryopreserved;
KW  - Storage--alteplase--cryopreserved;
KW  - Freezing--alteplase--stability;
KW  - Thawing--alteplase--stability;
KW  - Temperature--alteplase--stability;
KW  - Thrombolytic agents--alteplase--stability;
KW  - Diluents--water for injection--alteplase;
KW  - Containers--polypropylene--alteplase;
KW  - Solutions--alteplase--stability;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Li, Qiao
AU  - Imhof, Axel
AU  - Collingwood, Trevor N.
AU  - Urnov, Fyodor D.
AU  - Wolffe, Alan P.
T1  - p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/10/15/
VL  - 18
IS  - 20
M3  - Article
SP  - 5634
EP  - 5652
SN  - 02614189
AB  - We investigate the role of the transcriptional coactivator p300 in gene activation by thyroid hormone receptor (TR) on addition of ligand. The ligand-bound TR targets chromatin disruption independently of gene activation. Exogenous p300 facilitates transcription from a disrupted chromatin template, but does not itself disrupt chromatin in the presence or absence of ligand-bound receptor. Nevertheless, the acetyltransferase activity of p300 is required to facilitate transcription from a disrupted chromatin template. Expression of E1A prevents aspects of chromatin remodeling and transcriptional activation dependent on TR and p300. E1A selectively inhibits the acetylation of non-histone substrates. E1A does not prevent the assembly of a DNase I-hypersensitive site induced by TR, but does inhibit topological alterations and the loss of canonical nucleosome arrays dependent on the addition of ligand. Mutants of E1A incompetent for interaction with p300 partially inhibit chromatin disruption but still allow nuclear receptors to activate transcription. We conclude that p300 has no essential role in chromatin disruption, but makes use of acetyltransferase activity to stimulate transcription at a subsequent step. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHROMATIN
KW  - ACETYLATION
KW  - NONHISTONE chromosomal proteins
KW  - THYROID hormones
KW  - NUCLEAR receptors (Biochemistry)
KW  - PROTEIN-protein interactions
KW  - chromatin disruption
KW  - e1a
KW  - non-histone acetylation
KW  - nuclear receptors
KW  - p300
N1  - Accession Number: 13004357; Li, Qiao 1 Imhof, Axel 1 Collingwood, Trevor N. 1 Urnov, Fyodor D. 1 Wolffe, Alan P. 1; Email Address: awlme@helix.nih.gov; Affiliation:  1: Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5431, USA; Source Info: 10/15/99, Vol. 18 Issue 20, p5634; Subject Term: CHROMATIN; Subject Term: ACETYLATION; Subject Term: NONHISTONE chromosomal proteins; Subject Term: THYROID hormones; Subject Term: NUCLEAR receptors (Biochemistry); Subject Term: PROTEIN-protein interactions; Author-Supplied Keyword: chromatin disruption; Author-Supplied Keyword: e1a; Author-Supplied Keyword: non-histone acetylation; Author-Supplied Keyword: nuclear receptors; Author-Supplied Keyword: p300; Number of Pages: 19p; Document Type: Article
L3  - 10.1093/emboj/18.20.5634
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107231485
T1  - Prostate cancer practice patterns and quality of life: the prostate cancer outcomes study.
AU  - Potosky AL
AU  - Harlan LC
AU  - Stanford JL
AU  - Gilliland FD
AU  - Hamilton AS
AU  - Albertsen PC
AU  - Eley JW
AU  - Liff JM
AU  - Deapen D
AU  - Stephenson RA
AU  - Legler J
AU  - Ferrans CE
AU  - Talcott JA
AU  - Litwin MS
Y1  - 1999/10/20/
N1  - Accession Number: 107231485. Language: English. Entry Date: 19991201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Disease-Specific Index; Selected Scales from the Medical Outcomes Study (MOS) 36-item Short Form Health Survey (SF-36). NLM UID: 7503089. 
KW  - Prostatic Neoplasms
KW  - Quality of Life
KW  - Clinical Assessment Tools
KW  - Study Design
KW  - Chi Square Test
KW  - Record Review
KW  - T-Tests
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Human
SP  - 1719
EP  - 1724
JO  - JNCI: Journal of the National Cancer Institute
JF  - JNCI: Journal of the National Cancer Institute
JA  - J NATL CANCER INST
VL  - 91
IS  - 20
PB  - Oxford University Press / USA
SN  - 0027-8874
AD  - National Institutes of Health, EPN, Rm. 313, 6130 Executive Blvd., MSC 7344, Bethesda, MD 20892-7344; e-mail: potosky@nih.gov
U2  - PMID: 10528021.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107231485&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Yanovski, Jack A.
AU  - Yanovski, Susan Z.
AU  - Yanovski, J A
AU  - Yanovski, S Z
T1  - Recent advances in basic obesity research.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/10/27/
VL  - 282
IS  - 16
M3  - journal article
SP  - 1504
EP  - 1506
SN  - 00987484
AB  - Discusses advances in obesity research.  How more than 50 percent of United States adults are overweight; Reasons for obesity, including genetic factors; Role of leptin in weight gain and loss; Importance of a healthy diet and exercise; Need for more research to learn how to treat obesity successfully.
KW  - OBESITY
KW  - WEIGHT loss
KW  - DIET
KW  - GENETIC research
KW  - UNITED States
N1  - Accession Number: 2415177; Yanovski, Jack A. Yanovski, Susan Z. Yanovski, J A 1 Yanovski, S Z; Affiliation:  1: Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 10/27/99, Vol. 282 Issue 16, p1504; Subject Term: OBESITY; Subject Term: WEIGHT loss; Subject Term: DIET; Subject Term: GENETIC research; Subject Term: UNITED States; NAICS/Industry Codes: 541710 Research and development in the  physical, engineering and life sciences; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Graph; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107149807
T1  - Review: polyclonal intravenous immunoglobulin reduced mortality in bacterial sepsis...commentary on Alejandria MM, Lansang MA, Dans LF et al. Intravenous immunoglobulin for treating sepsis and septic shock. Cochrane Review, latest version 22 Feb 1999. In: The Cochrane Library. Oxford: Update Software
AU  - Cui X
AU  - Eichacker PQ
Y1  - 1999/11//1999 Nov-Dec
N1  - Accession Number: 107149807. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824. 
KW  - Immunoglobulins, Intravenous -- Therapeutic Use
KW  - Sepsis -- Drug Therapy
KW  - Shock, Septic -- Drug Therapy
KW  - Clinical Trials
KW  - Meta Analysis
KW  - Treatment Outcomes
KW  - Sepsis -- Mortality
KW  - Shock, Septic -- Mortality
KW  - Length of Stay
KW  - P-Value
KW  - Confidence Intervals
KW  - Relative Risk
KW  - Female
KW  - Infant
KW  - Adult
SP  - 70
EP  - 70
JO  - ACP Journal Club
JF  - ACP Journal Club
JA  - ACP J CLUB
VL  - 131
IS  - 3
CY  - Philadelphia, Pennsylvania
PB  - American College of Physicians
SN  - 1056-8751
AD  - National Institutes of Health, Bethesda, Maryland
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107099338
T1  - Regions of the human brain affected during a liquid-metal taste perception in the fasting state: a positron emission tomography study.
AU  - Gautier J
AU  - Chen K
AU  - Uecker A
AU  - Bandy D
AU  - Frost J
AU  - Salbe AD
AU  - Pratley RE
AU  - Lawson M
AU  - Ravussin E
AU  - Reiman EM
AU  - Tataranni PA
Y1  - 1999/11//
N1  - Accession Number: 107099338. Language: English. Entry Date: 20000401. Revision Date: 20150819. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Visual Analog Scaling. NLM UID: 0376027. 
KW  - Brain
KW  - Taste
KW  - Perception
KW  - Fasting
KW  - Tomography, Emission-Computed
KW  - Cerebrovascular Circulation -- Evaluation
KW  - Food, Formulated
KW  - Beverages
KW  - Cerebral Cortex
KW  - Thalamus
KW  - Male
KW  - Descriptive Statistics
KW  - Magnetic Resonance Imaging
KW  - Data Analysis, Computer Assisted
KW  - Analysis of Covariance
KW  - Visual Analog Scaling
KW  - Scales
KW  - Comparative Studies
KW  - Human
SP  - 806
EP  - 810
JO  - American Journal of Clinical Nutrition
JF  - American Journal of Clinical Nutrition
JA  - AM J CLIN NUTR
VL  - 70
IS  - 5
CY  - Bethesda, Maryland
PB  - American Society for Nutrition
AB  - Background: The sensation of taste provides reinforcement for eating and is of possible relevance to the clinical problem of obesity. Objective: Positron emission tomography (PET) was used to explore regions of the brain that were preferentially affected during the taste perception of a liquid meal by 11 right-handed, lean men in the fasting state. Design: After subjects had fasted for 36 h, 2 measurements of regional cerebral blood flow (rCBF) obtained immediately after subjects retained and swallowed 2 mL of a flavored liquid meal (the taste condition) were compared with 2 measurements of rCBF obtained immediately after subjects retained and swallowed 2 mL of water (the baseline condition). Results: Compared with the baseline condition, taste was associated with increased rCBF (P < 0.005) in the left dorsolateral prefrontal cortex and superior temporal gyrus, the right ventrolateral prefrontal cortex, supramarginal gyrus, and anterior thalamus; and bilaterally in the hippocampal formation, posterior cingulate, midbrain, occipital cortex, and cerebellum. Taste was also associated with decreased rCBF (P < 0.005) in the right dorsolateral prefrontal cortex, superior temporal gyrus, and supplementary motor area, and bilaterally in the medial prefrontal cortex and inferior parietal lobule. Conclusions: This exploratory study provides additional evidence that the temporal cortex, thalamus, cingulate cortex, caudate, and hippocampal formation are preferentially affected by taste stimulation. The asymmetric pattern of activity in the dorsolateral prefrontal cortex and superior temporal gyrus may contribute to the taste perception of a liquid meal perceived as pleasant. Additional studies are required to determine how these regions are affected in patients with obesity or anorexia. Copyright (c) 1999 American Society for Clinical Nutrition
SN  - 0002-9165
AD  - Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
U2  - PMID: 10539739.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107084239
T1  - Parenting strategies regarding teen behavior: parent and teen perceptions.
AU  - Haynie DL
AU  - Beck KH
AU  - Crump AD
AU  - Shattuck T
AU  - Simons-Morton B
Y1  - 1999/11//Nov/Dec99
N1  - Accession Number: 107084239. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9602338. 
KW  - Adolescent Behavior
KW  - Alcohol Drinking -- In Adolescence
KW  - Parenting
KW  - McNemar's Test
KW  - Parental Attitudes
KW  - Attitude -- In Adolescence
KW  - Drinking Behavior -- In Adolescence
KW  - Discipline -- In Adolescence
KW  - Adolescence
KW  - Age Factors
KW  - Family Characteristics
KW  - Attitude Measures
KW  - Risk Taking Behavior -- In Adolescence
KW  - Interviews
KW  - Questionnaires
KW  - Human
SP  - 403
EP  - 414
JO  - American Journal of Health Behavior
JF  - American Journal of Health Behavior
JA  - AM J HEALTH BEHAV
VL  - 23
IS  - 6
CY  - Oak Ridge, North Carolina
PB  - PNG Publications
AB  - Objective: To examine parents' awareness of their adolescents' alcohol-related behavior and compare parent and teen perceptions of parent strategies to manage teen behavior. Methods: Four hundred twenty-eight parents and their adolescents were recruited via random digit dialing for telephone interviews. Results: Parents underestimated their adolescents' alcohol-related behavior. Although most parents reported appropriate parenting strategies, they relied primarily on passive strategies to supervise teen behavior. Conclusion: Parents employed a limited repertoire of strategies to manage teen behavior. Parent education programs should foster proactive parenting by broadening parents' repertoire of strategies to monitor and manage their teens' behavior.
SN  - 1087-3244
AD  - Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Building 6100, Room 7B05, 9000 Rockville Pike, MSC 7510, Bethesda, MD 20892-7510; e-mail: Denise_Haynie@NIH.GOV
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107095162
T1  - Clinicopathological consultation. Review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of head and neck.
AU  - Carbone A
AU  - Devaney KO
AU  - Passannante A
AU  - Rinaldo A
AU  - Gloghini A
AU  - Ferlito A
Y1  - 1999/11//1999 Nov
N1  - Accession Number: 107095162. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0407300. 
KW  - Histiocytosis -- Pathology
KW  - Lymph Nodes -- Pathology
KW  - Paranasal Sinuses -- Pathology
KW  - Immunohistochemistry
KW  - Antigens, Surface -- Metabolism
KW  - Diagnosis, Differential
KW  - Neck
KW  - Microscopy
SP  - 1095
EP  - 1104
JO  - Annals of Otology, Rhinology & Laryngology
JF  - Annals of Otology, Rhinology & Laryngology
JA  - ANN OTOL RHINOL LARYNGOL
VL  - 108
IS  - 11 part 1
CY  - Thousand Oaks, California
PB  - Sage Publications Inc.
SN  - 0003-4894
AD  - Division of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107092601
T1  - Associative learning impairments in patients with frontal lobe damage.
AU  - Dimitrov M
AU  - Granetz J
AU  - Peterson M
AU  - Hollnagel C
AU  - Alexander G
AU  - Grafman J
Y1  - 1999/11//1999 Nov
N1  - Accession Number: 107092601. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. Instrumentation: Wechsler Adult Intelligence Scale-Revised (WAIS-R); Wechsler Memory Scale (WMS). NLM UID: 8218014. 
KW  - Learning
KW  - Frontal Lobe -- Physiopathology
KW  - Dementia -- Complications
KW  - Dementia -- Physiopathology
KW  - Learning Disorders -- Diagnosis
KW  - Learning Disorders -- Etiology
KW  - Analysis of Variance
KW  - Comparative Studies
KW  - Cues
KW  - P-Value
KW  - Memory Disorders -- Diagnosis
KW  - Memory Disorders -- Etiology
KW  - Memory
KW  - Severity of Illness Indices
KW  - Temporal Lobe -- Physiopathology
KW  - Scales
KW  - Wechsler Adult Intelligence Scale-Revised
KW  - Pearson's Correlation Coefficient
KW  - Multivariate Analysis of Variance
KW  - Descriptive Statistics
KW  - Repeated Measures
KW  - Neuropsychological Tests
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Male
KW  - Female
KW  - Human
SP  - 213
EP  - 230
JO  - Brain & Cognition
JF  - Brain & Cognition
JA  - BRAIN COGNIT
VL  - 41
IS  - 2
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
SN  - 0278-2626
AD  - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institute of Aging, National Institutes of Health
U2  - PMID: 10590820.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107092601&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107108728
T1  - A functional lesion in developmental dyslexia: left angular gyral blood flow predicts severity.
AU  - Rumsey JM
AU  - Horwitz B
AU  - Donohue BC
AU  - Nace KL
AU  - Maisog JM
AU  - Andreason P
Y1  - 1999/11//1999 Nov
N1  - Accession Number: 107108728. Language: English. Entry Date: 20000501. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Instrumentation: Wide Range Achievement Test-3 (WRAT-3); Lindamood Auditory Conceptualization Test (LAC); Wechsler Adult Intelligence Scale-Revised (WAIS-R); Goldman-Fristoe-Woodcock Sound Symbol Tests. Grant Information: Gulton Foundation, Tenafly, New Jersey. NLM UID: 7506220. 
KW  - Dyslexia -- Diagnosis
KW  - Cerebrovascular Circulation
KW  - Parietal Lobe -- Pathology
KW  - Temporal Lobe -- Pathology
KW  - Severity of Illness
KW  - Case Control Studies
KW  - Funding Source
KW  - Adult
KW  - Male
KW  - Intelligence Tests
KW  - Tomography, Emission-Computed
KW  - Clinical Assessment Tools
KW  - Wechsler Adult Intelligence Scale-Revised
KW  - Reading
KW  - Language Tests
KW  - Pearson's Correlation Coefficient
KW  - One-Tailed Test
KW  - Two-Tailed Test
KW  - Fisher's Exact Test
KW  - Human
SP  - 187
EP  - 204
JO  - Brain & Language
JF  - Brain & Language
JA  - BRAIN LANG
VL  - 70
IS  - 2
CY  - Burlington, Massachusetts
PB  - Academic Press Inc.
AB  - Functional imaging studies have shown reduced regional cerebral blood flow (rCBF) in temporal and inferior parietal regions in dyslexia. To relate such abnormalities to the severity of dyslexia, correlations between reading skill and rCBF during a series of reading tasks and visual fixation were mapped for 17 right-handed dyslexic men, ages 18-40, and 14 matched controls. These correlations uniquely identified the left angular gyrus as the most probable site of a functional lesion in dyslexia: Here, higher rCBF was associated with better reading skill in controls (p <.01), but with worse reading skill in dyslexia (p <.01). This suggests that greater reliance on this region normally facilitates reading, but impairs reading in dyslexia. Thus, developmental dyslexia may share a common localization with alexia. Copyright 1999 Academic Press.
SN  - 0093-934X
AD  - Clinical Neuroscience Branch, National Institute of Mental Health, Neuroscience Center, 6001 Executive Boulevard, MSC 9639, Bethesda, MD 20892. E-mail: jrumsey@box-j-nih.gov
U2  - PMID: 10550226.
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107108728&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 106972435
T1  - Commentary on 'Lung cancer screening in high-risk populations'.
AU  - Mulshine JL
Y1  - 1999/11//1999 Nov
N1  - Accession Number: 106972435. Language: English. Entry Date: 20021025. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Seigfried JM. Lung cancer screening in high-risk populations. (CLIN LUNG CANCER) 1999 Nov; 1 (2): 100-106. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 100893225. 
KW  - Lung Neoplasms -- Prevention and Control
KW  - Cancer Screening -- Methods
KW  - Lung Neoplasms -- Etiology
KW  - Lung Neoplasms -- Risk Factors
KW  - Smoking -- Complications
KW  - Biological Markers
SP  - 107
EP  - 107
JO  - Clinical Lung Cancer
JF  - Clinical Lung Cancer
JA  - CLIN LUNG CANCER
VL  - 1
IS  - 2
CY  - New York, New York
PB  - Elsevier Science
SN  - 1525-7304
AD  - Department of Cell and Cancer Biology, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD
U2  - PMID: 14733655.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107084438
T1  - Double take: an intriguing diagnosis. A case of vasculitic neuropathy: when early intervention can forestall serious complications.
AU  - Saie MW
AU  - Ciccone E
AU  - Grunnet ML
Y1  - 1999/11//
N1  - Accession Number: 107084438. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; algorithm; case study; pictorial; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110. 
KW  - Vasculitis -- Classification
KW  - Vasculitis -- Diagnosis
KW  - Peripheral Nervous System Diseases -- Diagnosis
KW  - Vasculitis -- Drug Therapy
KW  - Drug Therapy, Combination
KW  - Prognosis
KW  - Recurrence
KW  - Female
KW  - Aged
SP  - 3135
EP  - 3141
JO  - Consultant (00107069)
JF  - Consultant (00107069)
JA  - CONSULTANT
VL  - 39
IS  - 11
CY  - Framingham, Massachusetts
PB  - United Business Media
SN  - 0010-7069
AD  - National Cancer Institute
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Lorberbaum, Jeffrey P.
AU  - Newman, John D.
AU  - Dubno, Judy R.
AU  - Horwitz, Amy R.
AU  - Nahas, Ziad
AU  - Teneback, Charlotte C.
AU  - Bloomer, Courtnay W.
AU  - Bohning, Daryl E.
AU  - Vincent, Diana
AU  - Johnson, Michael R.
AU  - Emmanuel, Naresh
AU  - Brawman-Mintzer, Olga
AU  - Book, Sarah W.
AU  - Lydiard, R. Bruce
AU  - Ballenger, James C.
AU  - George, Mark S.
T1  - Feasibility of using fMRI to study mothers responding to infant cries.
JO  - Depression & Anxiety (1091-4269)
JF  - Depression & Anxiety (1091-4269)
Y1  - 1999/11//
VL  - 10
IS  - 3
M3  - Article
SP  - 99
EP  - 104
PB  - John Wiley & Sons, Inc.
SN  - 10914269
AB  - While parenting is a universal human behavior, its neuroanatomic basis is currently unknown. Animal data suggest that the cingulate may play an important function in mammalian parenting behavior. For example, in rodents cingulate lesions impair maternal behavior. Here, in an attempt to understand the brain basis of human maternal behavior, we had mothers listen to recorded infant cries and white noise control sounds while they underwent functional MRI (fMRI) of the brain. We hypothesized that mothers would show significantly greater cingulate activity during the cries compared to the control sounds. Of 7 subjects scanned, 4 had fMRI data suitable for analysis. When fMRI data were averaged for these 4 subjects, the anterior cingulate and right medial prefrontal cortex were the only brain regions showing statistically increased activity with the cries compared to white noise control sounds (cluster analysis with one-tailed z-map threshold of P < 0.001 and spatial extent threshold of P < 0.05). These results demonstrate the feasibility of using fMRI to study brain activity in mothers listening to infant cries and that the anterior cingulate may be involved in mothers listening to crying babies. We are currently replicating this study in a larger group of mothers. Future work in this area may help (1) unravel the functional neuroanatomy of the parent-infant bond and (2) examine whether markers of this bond, such as maternal brain response to infant crying, can predict maternal style (i.e., child neglect), offspring temperament, or offspring depression or anxiety. Depression and Anxiety 10:99–104, 1999. © 1999 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Depression & Anxiety (1091-4269) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PARENTING
KW  - HUMAN behavior
KW  - MOTHER & child
KW  - CRYING in infants
KW  - ANXIETY
KW  - anterior cingulate
KW  - attachment
KW  - fMRI
KW  - imaging
KW  - infant crying
KW  - maternal behavior
KW  - social bonding
N1  - Accession Number: 11772872; Lorberbaum, Jeffrey P. 1; Email Address: lorberjp@musc.edu Newman, John D. 2 Dubno, Judy R. 1 Horwitz, Amy R. 1 Nahas, Ziad 1 Teneback, Charlotte C. 1 Bloomer, Courtnay W. 1 Bohning, Daryl E. 1 Vincent, Diana 1 Johnson, Michael R. 1 Emmanuel, Naresh 1 Brawman-Mintzer, Olga 1 Book, Sarah W. 1 Lydiard, R. Bruce 1 Ballenger, James C. 1 George, Mark S. 1; Affiliation:  1: Medical University of South Carolina, Charleston, South Carolina  2: National Institute of Child Health and Human Development, NIH, Bethesda, Maryland; Source Info: 1999, Vol. 10 Issue 3, p99; Subject Term: PARENTING; Subject Term: HUMAN behavior; Subject Term: MOTHER & child; Subject Term: CRYING in infants; Subject Term: ANXIETY; Author-Supplied Keyword: anterior cingulate; Author-Supplied Keyword: attachment; Author-Supplied Keyword: fMRI; Author-Supplied Keyword: imaging; Author-Supplied Keyword: infant crying; Author-Supplied Keyword: maternal behavior; Author-Supplied Keyword: social bonding; Number of Pages: 6p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Chew, E.Y.
T1  - Disease Management by Prevention: The Prospects for Diabetic Retinopathy.
JO  - Disease Management & Health Outcomes
JF  - Disease Management & Health Outcomes
Y1  - 1999/11//
VL  - 6
IS  - 5
M3  - Article
SP  - 279
EP  - 290
PB  - Springer Science & Business Media B.V.
SN  - 11738790
AB  - Diabetic retinopathy is a significant cause of visual loss in developed countries. Data from epidemiological studies and controlled clinical trials have resulted in treatment strategies, which are highly successful in preventing blindness. These strategies involve measures that require both education and compliance of the individual with diabetes mellitus and the education of physicians and paramedical staff who deliver care to these patients. This paper presents the classification of diabetic retinopathy and the treatment strategies, both the preventive measures and the active treatment modalities used for diabetic retinopathy. Persons with diabetes should be invited from the first day of diagnosis to be active partners working towards the prevention of diabetic complications. The management of patients with diabetes includes essential medical preventive measures such as tight glucose level and blood pressure control and the lowering of serum cholesterol levels to successfully decrease the risk of microvascular complications, namely diabetic retinopathy, neuropathy and nephropathy. Persons with diabetes should also be aware of the importance of screening for diabetic retinopathy and the beneficial effects of timely laser photocoagulation and other surgical interventions. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Disease Management & Health Outcomes is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - DIABETIC retinopathy
KW  - PREVENTION
KW  - DIABETES -- Complications
KW  - RETINAL diseases
KW  - Antihypertensives, therapeutic-use
KW  - Diabetic-retinopathy, general
KW  - Hypertension-in-diabetes, treatment
KW  - Insulin, therapeutic-use
KW  - Patient-compliance
KW  - Pharmacoeconomics
KW  - Reviews-on-disease
KW  - Reviews-on-treatment
N1  - Accession Number: 9523573; Chew, E.Y. 1; Affiliation:  1: Division of Biometry and Epidemiology, National Eye Institute/National Institutes of Health, Bethesda, Maryland, USA; Source Info: Nov99, Vol. 6 Issue 5, p279; Subject Term: DIABETIC retinopathy; Subject Term: PREVENTION; Subject Term: DIABETES -- Complications; Subject Term: RETINAL diseases; Author-Supplied Keyword: Antihypertensives, therapeutic-use; Author-Supplied Keyword: Diabetic-retinopathy, general; Author-Supplied Keyword: Hypertension-in-diabetes, treatment; Author-Supplied Keyword: Insulin, therapeutic-use; Author-Supplied Keyword: Patient-compliance; Author-Supplied Keyword: Pharmacoeconomics; Author-Supplied Keyword: Reviews-on-disease; Author-Supplied Keyword: Reviews-on-treatment; Number of Pages: 12p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Harada, Naomoto
AU  - Tamai, Yoshitaka
AU  - Ishikawa, Tomo-o
AU  - Sauer, Brian
AU  - Takaku, Kazuaki
AU  - Oshima, Masanobu
AU  - Taketo, Makoto M.
T1  - Intestinal polyposis in mice with a dominant stable mutation of the ß-catenin gene.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/11//11/1/99
VL  - 18
IS  - 21
M3  - Article
SP  - 5931
EP  - 5942
SN  - 02614189
AB  - Ectopic expression of certain Wnt genes in mouse mammary tissue is tumorigenic, and mutations that stabilize β-catenin are found in various human cancers including colorectal cancer. To determine the role of stabilized β-catenin in intestinal tumorigenesis in mice, we constructed by embryonic stem (ES) cell-mediated homologous recombination, a mutant β-catenin allele whose exon 3 was sandwiched by loxP sequences. When the germline heterozygotes were crossed with mice expressing Cre recombinase in the intestines, the serines and threonine encoded by exon 3 and to be phosphorylated by glycogen synthase kinase 3β (GSK3β) were deleted in the offspring intestines, which caused adenomatous intestinal polyps resembling those in ApcΔ716 knockout mice. Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - GENE expression
KW  - MAMMARY glands
KW  - MUTATION (Biology)
KW  - CARCINOGENESIS
KW  - PATHOLOGY
KW  - GENETIC toxicology
KW  - cell adhesion
KW  - cell migration
KW  - colon cancer
KW  - tcf-lef
KW  - wnt signaling
N1  - Accession Number: 13004403; Harada, Naomoto 1 Tamai, Yoshitaka 1 Ishikawa, Tomo-o 1 Sauer, Brian 2,3 Takaku, Kazuaki 4 Oshima, Masanobu 1 Taketo, Makoto M. 4; Email Address: taketo@mol.f.u-tokyo.ac.jp; Affiliation:  1: Banyu Tsukuba Research Institute (Merek), Tsukuba 300-2611  2: Japan  3: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA  4: Developmental Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Source Info: 11/1/99, Vol. 18 Issue 21, p5931; Subject Term: GENE expression; Subject Term: MAMMARY glands; Subject Term: MUTATION (Biology); Subject Term: CARCINOGENESIS; Subject Term: PATHOLOGY; Subject Term: GENETIC toxicology; Author-Supplied Keyword: cell adhesion; Author-Supplied Keyword: cell migration; Author-Supplied Keyword: colon cancer; Author-Supplied Keyword: tcf-lef; Author-Supplied Keyword: wnt signaling; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/18.21.5931
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kiernan, Rosemary E.
AU  - Vanhulle, Caroline
AU  - Schiltz, Lou
AU  - Adam, Emmanuelle
AU  - Hua Xiao
AU  - Maudoux, Frédéric
AU  - Calomme, Claire
AU  - Burny, Arsène
AU  - Nakatani, Yoshihiro
AU  - Kuan-Teh Jeang
AU  - Benkirane, Monsef
AU  - Van Lint, Carine
T1  - HIV-1 Tat transcriptional activity is regulated by acetylation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/11//11/1/99
VL  - 18
IS  - 21
M3  - Article
SP  - 6106
EP  - 6118
SN  - 02614189
AB  - The human immunodeficiency virus (HIV) trans-activator protein, Tat, stimulates transcription from the viral long-terminal repeats (LTR) through an RNA hairpin element, trans-activation responsive region (TAR). We and others have shown that trans-activator protein (Tat)-associated histone acetyltransferases (TAHs), p300 and p300/CBP-associating factor (PCAF), assist functionally in the activation of chromosomally integrated HIV-1 LTR. Here, we show that p300 and PCAF also directly acetylate Tat. We defined two sites of acetylation located in different functional domains of Tat. p300 acetylated Lys50 in the TAR RNA binding domain, while PCAF acetylated Lys28 in the activation domain of Tat. In support of a functional role for acetylation in vivo, histone deacetylase inhibitor (trichostatin A) synergized with Tat in transcriptional activation of the HIV-1 LTR. Synergism was TAR-dependent and required the intact presence of both Lys28 and Lys50. Mechanistically, acetylation at Lys28 by PCAF enhanced Tat binding to the Tat-associated kinase, CDK9/P-TEFb, while acetylation by p300 at Lys50 of Tat promoted the dissociation of Tat from TAR RNA that occurs during early transcription elongation. These data suggest that acetylation of Tat regulates two discrete and functionally critical steps in transcription, binding to an RNAP II CTD-kinase and release of Tat from TAR RNA. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - HIV (Viruses)
KW  - HIV infections
KW  - ACETYLTRANSFERASES
KW  - RNA
KW  - HISTONES
KW  - ACYLTRANSFERASES
KW  - PROTEIN binding
KW  - acetylation
KW  - hiv-1 tat
KW  - p300
KW  - pcaf
KW  - transcriptional activity
N1  - Accession Number: 13004387; Kiernan, Rosemary E. 1 Vanhulle, Caroline 2 Schiltz, Lou 3 Adam, Emmanuelle 2 Hua Xiao 4 Maudoux, Frédéric 2 Calomme, Claire 2 Burny, Arsène 2 Nakatani, Yoshihiro 3 Kuan-Teh Jeang 4 Benkirane, Monsef 1; Email Address: bmonsef@igh.cnrs.fr Van Lint, Carine 2; Email Address: cvlint@dbm.ulb.ac.be; Affiliation:  1: Laboratoire de Virologie Moléculaire et Transfert de Gène, Institut de Génétique Humaine, UPR1142 Montpellier, France  2: Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Laboratoire de Chimie Biologique, Rue des Professeurs Jeener et Brachet 12, Gosselies 6041, Belgium  3: National Institute of Child Health and Human Development, Laboratory of Molecular Micrbiology, NIAID, NIH, Bethesda, MD, USA  4: Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA; Source Info: 11/1/99, Vol. 18 Issue 21, p6106; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: ACETYLTRANSFERASES; Subject Term: RNA; Subject Term: HISTONES; Subject Term: ACYLTRANSFERASES; Subject Term: PROTEIN binding; Author-Supplied Keyword: acetylation; Author-Supplied Keyword: hiv-1 tat; Author-Supplied Keyword: p300; Author-Supplied Keyword: pcaf; Author-Supplied Keyword: transcriptional activity; Number of Pages: 13p; Document Type: Article
L3  - 10.1093/emboj/18.21.6106
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Landry, David J.
AU  - Kaeser, Lisa
AU  - Richards, Cory L.
T1  - Abstinence Promotion and the Provision Of Information About Contraception in Public School District Sexuality Education Policies.
JO  - Family Planning Perspectives
JF  - Family Planning Perspectives
Y1  - 1999/11//Nov/Dec99
VL  - 31
IS  - 6
M3  - Article
SP  - 280
PB  - Guttmacher Institute, Inc.
SN  - 00147354
AB  - Context: For more than two decades, abstinence from sexual intercourse has been promoted by some advocates as the central, if not sole, component of public school sexuality education policies in the United States. Little is known, however, about the extent to which policies actually focus on abstinence and about the relationship, at the local district level, between policies on teaching abstinence and policies on providing information about contraception. Methods: A nationally representative sample of 825 public school district superintendents or their representatives completed a mailed questionnaire on sexuality education policies. Descriptive and multivariate analyses were conducted to identify districts that had sexuality education policies, their policy regarding abstinence education and the factors that influenced it. Results: Among the 69% of public school districts that have a district-wide policy to teach sexuality education, 14% have a comprehensive policy that treats abstinence as one option for adolescents in a broader sexuality education program; 51% teach abstinence as the preferred option for adolescents, but also permit discussion about contraception as an effective means of protecting against unintended pregnancy and disease (an abstinence-plus policy); and 35% (or 23% of all U.S. school districts) teach abstinence as the only option outside of marriage, with discussion of contraception either prohibited entirely or permitted only to emphasize its shortcomings (an abstinence-only policy). Districts in the South were almost five times as likely as those in the Northeast to have an abstinence-only policy. Among districts whose current policy replaced an earlier one, twice as many adopted a more abstinence-focused policy as moved in the opposite direction. Overall, though, there was no net increase among such districts in the number with an abstinence-only policy; instead, the largest change was toward abstinence-plus policies. Conclusions: While a growing number of U.S. public school districts have made abstinence education a part of their curriculum, two-thirds of districts allow at least some positive discussion of contraception to occur. Nevertheless, one school district in three forbids dissemination of any positive information about contraception, regardless of whether their students are sexually active or at risk of pregnancy or disease. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Family Planning Perspectives is the property of Guttmacher Institute, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SEXUAL abstinence
KW  - CONTRACEPTION
KW  - SEXUAL intercourse
KW  - SEX education
KW  - PUBLIC schools
KW  - SCHOOL districts
KW  - UNITED States
N1  - Accession Number: 2609860; Landry, David J. 1 Kaeser, Lisa 2 Richards, Cory L. 3; Affiliation:  1: Senior Research Associate, Alan Guttmacher Institute (AGI).  2: Legislative and Public Liason Officer, National Institute of Child Health and Human Development, Bethesda, MD.  3: Vice President for Public Policy, Alan Guttmacher Institute (AGI).; Source Info: Nov/Dec99, Vol. 31 Issue 6, p280; Subject Term: SEXUAL abstinence; Subject Term: CONTRACEPTION; Subject Term: SEXUAL intercourse; Subject Term: SEX education; Subject Term: PUBLIC schools; Subject Term: SCHOOL districts; Subject Term: UNITED States; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 7193
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bhattacharyya, S. P.
AU  - Mekori, Y. A.
AU  - Hoh, D.
AU  - Paolini, R.
AU  - Metcalfe, D. D.
AU  - Bianchine, P. J.
T1  - Both adhesion to immobilized vitronectin and FcℇRI cross‐linking cause enhanced focal adhesion kinase phosphorylation in murine mast cells.
JO  - Immunology
JF  - Immunology
Y1  - 1999/11//
VL  - 98
IS  - 3
M3  - Article
SP  - 357
EP  - 362
PB  - Wiley-Blackwell
SN  - 00192805
AB  - Summary Murine mast cells adhere spontaneously to plate‐bound vitronectin (VNPB) via αv‐containing integrins, and this adhesive interaction results in an augmented interleukin‐3 (IL‐3)‐dependent mast‐cell proliferation. In this report we demonstrate that the activation of murine mast cells through αv‐integrin, as well as through the high affinity immunoglobulin E (IgE) receptor (FcℇRI), results in enhanced tyrosine phosphorylation of focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase involved in mitogenic and oncogenic signal transduction. While mast cell adhesion to VNPB resulted in enhanced FAK phosphorylation, treatment with soluble vitronectin (VNSOL) failed to do so. Spontaneous mast cell adhesion to entactin (EN) did not induce tyrosine phosphorylation of FAK, demonstrating that not all adhesive interactions lead to the same sequence of biochemical events. Because FAK has intrinsic tyrosine kinase activity, we examined whether activating mast cells via αv‐integrins, or via FcℇRI‐cross‐linking stimulated the in vitro kinase activity of FAK. Both pathways were found independently to activate FAK in mast cells and together appeared additive. Protein kinase C depletion in mast cells and calcium depletion in the medium caused decreased tyrosine phosphorylation of FAK, indicating that optimal tyrosine phosphorylation of FAK is regulated by both pathways. These data are consistent with the conclusion that the tyrosine phosphorylation of FAK represents at least one example of a point of convergence in the intracellular tyrosine phosphorylation cascades induced by αv integrin‐and FcℇRI‐mediated signal transduction pathways in mast cells. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PHOSPHORYLATION
KW  - MAST cells
N1  - Accession Number: 5605472; Bhattacharyya, S. P. 1 Mekori, Y. A. 2 Hoh, D. 1 Paolini, R. 3 Metcalfe, D. D. 1 Bianchine, P. J. 1; Affiliation:  1: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, USA,  2: Department of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel  3: Department of Experimental Medicine and Pathology, University ‘La Sapienza,’ Rome, Italy, and; Source Info: Nov99, Vol. 98 Issue 3, p357; Subject Term: PHOSPHORYLATION; Subject Term: MAST cells; Number of Pages: 6p; Illustrations: 9 Diagrams; Document Type: Article
L3  - 10.1046/j.1365-2567.1999.00883.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107086176
T1  - Challenges. Prevention of breast cancer in high-risk women: a case study.
AU  - Goldstein JL
AU  - Cusack GJ
AU  - Noone M
Y1  - 1999/11//1999 Nov
N1  - Accession Number: 107086176. Language: English. Entry Date: 20000201. Revision Date: 20150818. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9889728. 
KW  - Breast Neoplasms -- Prevention and Control
KW  - Risk Assessment
KW  - Family History
KW  - Education, Continuing (Credit)
KW  - Models, Statistical
KW  - Chemoprevention
KW  - Mastectomy
KW  - Clinical Trials
KW  - Breast Neoplasms -- Familial and Genetic
KW  - Adult
KW  - Middle Age
KW  - Female
SP  - 91
EP  - 105
JO  - Innovations in Breast Cancer Care
JF  - Innovations in Breast Cancer Care
JA  - INNOV BREAST CANCER CARE
VL  - 4
IS  - 3
PB  - Meniscus Educational Institute
SN  - 1082-1341
AD  - Oncology Nurse Practitioner, Medical Oncology Branch, National Cancer Institute
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107086176&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Hawkins, Vivian
AU  - Qian Shen, Vivian
AU  - Chuang Chin Chiueh
T1  - Kynostatin and 17β-Estradiol Prevent the Apoptotic Death of Human Neuroblastoma Cells Exposed to HIV-1 Protease.
JO  - Journal of Biomedical Science
JF  - Journal of Biomedical Science
Y1  - 1999/11//
VL  - 6
IS  - 6
M3  - Article
SP  - 433
EP  - 438
PB  - BioMed Central
SN  - 10217770
AB  - A significant number of adult male patients with acquired immunodeficiency syndrome develop cerebral atrophy and progressive brain disorders such as dementia complex and neuropsychiatric problems. Upon entering the brain via activated macrophages or microglias, the human immunodeficiency type 1 virus (HIV-1) may produce cytotoxic factors such as HIV-1 envelope protein (gp120) and protease. Owing to significant proteolysis of nonviral proteins, the protease derived from HIV-1 may be detrimental to brain cells and neurons. Our results revealed that HIV-1 protease, at nanomolar concentrations, was as potent as gp120 in causing neurotoxicity in human neuroblastoma neurotypic SH-SY5Y cells. As shown by the Oncor ApopTag staining procedure, HIV-1 protease significantly increased the number of apoptotic cells over the serum-free controls. Moreover, HIV-1 protease-induced neurotoxicity was blocked by a selective protease inhibitor, kynostatin (KNI-272). Antioxidants such as 17β-estradiol, melatonin, and S-nitrosoglutathione also prevented protease-induced neurotoxicity. These findings indicate that oxidative proteolysis may mediate HIV-1 protease-induced apoptosis and the degeneration of neurons and other brain cells. Centrally active protease inhibitors and antioxidants may play an important role in preventing cerebral atrophy and associated dementia complex caused by HIV-1. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AIDS dementia complex
KW  - AIDS (Disease) -- Complications
KW  - ANTIOXIDANTS
KW  - CHEMICAL inhibitors
KW  - APOPTOSIS
KW  - HIV-positive persons
KW  - NEUROBLASTOMA
KW  - PROTEASE inhibitors
KW  - ENZYME inhibitors
KW  - Antioxidants
KW  - Apoptosis
KW  - Cerebral atrophy
KW  - gp120
KW  - HIV-1 protease
KW  - Human neuroblastoma cell
KW  - Neuroprotection
KW  - Protease inhibitor (KNI-272)
N1  - Accession Number: 11372109; Hawkins, Vivian 1 Qian Shen, Vivian 1 Chuang Chin Chiueh 2; Email Address: chiueh@helix.nih.gov; Affiliation:  1: Howard Huges Medical Institute Student Teacher Internship Program, Montgomery County Public School, and National Institutes of Health, Bethesda, Md., USA  2: Unit on Neurodegeneration and Neuroprotection, Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Md., USA; Source Info: 1999, Vol. 6 Issue 6, p433; Subject Term: AIDS dementia complex; Subject Term: AIDS (Disease) -- Complications; Subject Term: ANTIOXIDANTS; Subject Term: CHEMICAL inhibitors; Subject Term: APOPTOSIS; Subject Term: HIV-positive persons; Subject Term: NEUROBLASTOMA; Subject Term: PROTEASE inhibitors; Subject Term: ENZYME inhibitors; Author-Supplied Keyword: Antioxidants; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cerebral atrophy; Author-Supplied Keyword: gp120; Author-Supplied Keyword: HIV-1 protease; Author-Supplied Keyword: Human neuroblastoma cell; Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: Protease inhibitor (KNI-272); Number of Pages: 6p; Illustrations: 5 Graphs; Document Type: Article
L3  - 10.1159/000025419
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
TY  - GEN
AU  - McCaskill-Stevens, W.;
AU  - Hawk, E. T.;
AU  - Flynn, P. J.;
AU  - Lippman, S. M.;
T1  - National Cancer Institute supported cancer chemoprevention research: coming of age
CT  - National Cancer Institute supported cancer chemoprevention research: coming of age
JO  - Journal of Clinical Oncology (USA)
JF  - Journal of Clinical Oncology (USA)
Y1  - 1999/11/01/
VL  - 17
IS  - Nov Suppl
SP  - 53
EP  - 62
SN  - 0732183X
AD  - Div. of Cancer Prevention, Natl. Cancer Inst., 6130 Executive Blvd., Rm. 300, Bethesda, MD 20892, USA Internet: wm57@nih.gov
N1  - Accession Number: 37-13850; Language: English; References: 58; Publication Type: Review; Journal Coden: JCONDN; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Yinghua Shu Wang
N2  - A review of cancer chemoprevention research supported by the National Cancer Institute (NCI) is presented, including the structure of the NCI division of cancer prevention and its chemoprovention program, clinical trials, and the discovery and development of chemopreventive agents.
KW  - Neoplasms--prophylaxis--research;
KW  - Clinical studies--neoplasms--prophylaxis;
KW  - National Cancer Institute--research--neoplasms prophylaxis;
KW  - Research--neoplasms--prophylaxis;
KW  - Product development--drugs--neoplasms prophylaxis;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=37-13850&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Krauzlis, R. J.
AU  - Zivotofsky, A. Z.
AU  - Miles, F. A.
T1  - Target Selection for Pursuit and Saccadic Eye Movements in Humans.
JO  - Journal of Cognitive Neuroscience
JF  - Journal of Cognitive Neuroscience
Y1  - 1999/11//
VL  - 11
IS  - 6
M3  - Article
SP  - 641
EP  - 649
PB  - MIT Press
SN  - 0898929X
AB  - Eye movements were recorded from three subjects as they initiated tracking of a small circle (''target'') moving leftward or rightward, above or below the horizontal meridian, either alone or in the presence of a small square (''distractor'') moving leftward or rightward on the other side of the horizontal meridian. At the start of each trial, subjects were provided with either a ''form'' cue (always centrally positioned and having the circular shape and color of the upcoming moving target) or a ''location'' cue (a small white square positioned where the upcoming target would appear). The latency of pursuit increased in the presence of an oppositely moving distractor when subjects were provided the form cues but not when they were provided the location cues. The latency of saccades showed similar, but smaller, increases when subjects were given the form cues. On many trials with the form cues, pursuit started in the direction of the distractor and then reversed to follow the target. On these trials, the initial saccade often, but not always, also followed the distractor. These results indicate that the mechanisms of target selection for pursuit and saccades are tightly coordinated but not strictly yoked. The shared effects of the distractor on the latencies of pursuit and saccades probably reflect the common role of visual attention in filtering the inputs that guide these two types of eye movements. The differences in the details of the effects on pursuit and saccades suggest that the neural mechanisms that trigger these two movements can be independently regulated. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SACCADIC eye movements
KW  - EYE -- Movements
N1  - Accession Number: 2564074; Krauzlis, R. J. 1 Zivotofsky, A. Z. 2 Miles, F. A. 2; Affiliation:  1: Salk Institute for Biological Studies  2: National Eye Institute; Source Info: Nov99, Vol. 11 Issue 6, p641; Subject Term: SACCADIC eye movements; Subject Term: EYE -- Movements; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Graphs; Document Type: Article; Full Text Word Count: 5028
L3  - 10.1162/089892999563706
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107086259
T1  - Observed behaviors of patients with probable Alzheimer's disease who are hospitalized for diagnostic tests.
AU  - Day N
AU  - Musallam K
AU  - Wells M
Y1  - 1999/11//1999 Nov
N1  - Accession Number: 107086259. Language: English. Entry Date: 20000201. Revision Date: 20150818. Publication Type: Journal Article; forms; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 7510258. 
KW  - Alzheimer's Disease
KW  - Behavioral Changes -- Evaluation -- In Old Age
KW  - Aged, Hospitalized -- Psychosocial Factors
KW  - Retrospective Design
KW  - Record Review
KW  - Neuropsychological Tests
KW  - Convenience Sample
KW  - Inpatients
KW  - Female
KW  - Male
KW  - Middle Age
KW  - Aged
KW  - Aged, 80 and Over
KW  - Pilot Studies
KW  - Chi Square Test
KW  - Severity of Illness
KW  - Diagnosis
KW  - Human
SP  - 35
EP  - 39
JO  - Journal of Gerontological Nursing
JF  - Journal of Gerontological Nursing
JA  - J GERONTOL NURS
VL  - 25
IS  - 11
CY  - Thorofare, New Jersey
PB  - SLACK Incorporated
AB  - Selecting the most appropriate nursing intervention is largely dependent on accurately assessing the patient's stage of Alzheimer's disease (AD). Frequently observed patient behaviors identified in this study included: restlessness, confusion, anxiety, agitation, somatic complaints, disrupted sleep patterns, and withdrawal. The impact of invasive procedures may be minimized when the psychological, social, and physical needs of patients with AD are anticipated and met through planned interventions. Educated caregivers can provide patients with AD support that will lead to the successful completion of diagnostic tests.
SN  - 0098-9134
AD  - Clinical Research Nurse, Nursing Dept, National Institutes of Health, Bethesda, Maryland
U2  - PMID: 10776160.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - van Turennout, Miranda
AU  - Hagoort, Peter
AU  - Brown, Colin
T1  - The Time Course of Grammatical and Phonological Processing During Speaking: Evidence from Event-Related Brain Potentials.
JO  - Journal of Psycholinguistic Research
JF  - Journal of Psycholinguistic Research
Y1  - 1999/11//
VL  - 28
IS  - 6
M3  - Article
SP  - 649
EP  - 676
PB  - Springer Science & Business Media B.V.
SN  - 00906905
AB  - Motor-related brain potentials were used to examine the time course of grammatical and phonological processes during noun phrase production in Dutch. In the experiments, participants named colored pictures using a no-determiner noun phrase. On half of the trials a syntactic–phonological classification task had to be performed before naming. Depending on the outcome of the classifications, a left or a right push-button response was given (go trials), or no push-button response was given (no-go trials). Lateralized readiness potentials (LRPs) were derived to test whether syntactic and phonological information affected the motor system at separate moments in time. The results showed that when syntactic information determined the response-hand decision, an LRP developed on no-go trials. However, no such effect was observed when phonological information determined response hand. On the basis of the data, it can be estimated that an additional period of at least 40 ms is needed to retrieve a word's initial phoneme once its lemma has been retrieved. These results provide evidence for the view that during speaking, grammatical processing precedes phonological processing in time. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Psycholinguistic Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Phonology (Grammar)
KW  - Compensatory lengthening (Phonetics)
KW  - Phonemics
KW  - Evoked potentials (Electrophysiology)
KW  - Electrophysiology
N1  - Accession Number: 11303328; van Turennout, Miranda 1; Hagoort, Peter 2; Brown, Colin 2; Affiliations: 1: Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. National Institute of Mental Health, Laboratory of Brain and Cognition, Bethesda, Maryland 20892-1366; 2: Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands; Issue Info: Nov1999, Vol. 28 Issue 6, p649; Thesaurus Term: Phonology (Grammar); Thesaurus Term: Compensatory lengthening (Phonetics); Thesaurus Term: Phonemics; Subject Term: Evoked potentials (Electrophysiology); Subject Term: Electrophysiology; Number of Pages: 28p; Document Type: Article
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DP  - EBSCOhost
DB  - ufh
ER  - 

TY  - JOUR
ID  - 107104525
T1  - Building a better mousetrap: toward an understanding of osteoporosis.
AU  - Slavkin HC
Y1  - 1999/11//
N1  - Accession Number: 107104525. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Jaw Diseases -- Diagnosis
KW  - Osteoporosis -- Diagnosis
KW  - Tooth Diseases -- Diagnosis
KW  - Information Resources
KW  - Risk Factors
KW  - Male
KW  - Female
KW  - Tooth Diseases -- Familial and Genetic
KW  - Tooth Diseases -- Drug Therapy
KW  - Osteoporosis -- Familial and Genetic
KW  - Osteoporosis -- Drug Therapy
KW  - Jaw Diseases -- Familial and Genetic
KW  - Jaw Diseases -- Drug Therapy
SP  - 1632
EP  - 1636
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 11
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - Director, National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, Md 20892-2290
U2  - PMID: 10573946.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107086322
T1  - Approach to therapy. Radiopharmaceuticals and their use in the current practice of nuclear medicine.
AU  - Fejka RM
Y1  - 1999/11//1999 Nov-Dec
N1  - Accession Number: 107086322. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Radiopharmaceuticals
KW  - Radiopharmaceuticals -- Legislation and Jurisprudence
KW  - Radiopharmaceuticals -- Administration and Dosage
KW  - Radiopharmaceuticals -- Diagnostic Use
KW  - Radiation Dosage
KW  - Radioisotopes
KW  - Tomography, Emission-Computed
SP  - 531
EP  - 545
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Bldg. 10, Room 1C-401, 10 Center Drive, MSC-1180, Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD 20892-1180
U2  - PMID: 10889704.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107086327
T1  - Patient education. Radioactive iodine administration for outpatients.
AU  - Fejka RM
Y1  - 1999/11//1999 Nov-Dec
N1  - Accession Number: 107086327. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704. 
KW  - Iodine Radioisotopes -- Diagnostic Use
KW  - Iodine Radioisotopes -- Therapeutic Use
KW  - Thyroid Gland -- Radiography
KW  - Outpatients
SP  - 581
EP  - 584
JO  - Lippincott's Primary Care Practice
JF  - Lippincott's Primary Care Practice
JA  - LIPPINCOTTS PRIM CARE PRACT
VL  - 3
IS  - 6
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 1088-5471
AD  - Chief of Clinical Nuclear Pharmacy, Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD
U2  - PMID: 10889709.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107151798
T1  - Cross-language positive priming disappears, negative priming does not: evidence for two sources of selective inhibition.
AU  - Neumann E
AU  - McCloskey MS
AU  - Felio AC
Y1  - 1999/11//
N1  - Accession Number: 107151798. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0357443. 
KW  - Language Processing
KW  - Attention
KW  - Cues
KW  - Multilingualism
KW  - Experimental Studies
KW  - Convenience Sample
KW  - Word Lists
KW  - Analysis of Variance
KW  - T-Tests
KW  - Questionnaires
KW  - Statistical Significance
KW  - Decision Making
KW  - Cognition
KW  - Reaction Time
KW  - Adult
KW  - Male
KW  - Female
KW  - Human
SP  - 1051
EP  - 1063
JO  - Memory & Cognition
JF  - Memory & Cognition
JA  - MEM COGNIT
VL  - 27
IS  - 6
CY  - , <Blank>
PB  - Springer Science & Business Media B.V.
AB  - The authors used a unilingual and bilingual primed lexical decision task to investigate priming effects produced by attended and ignored words. In the unilingual experiment, accelerated lexical decisions to probe target words resulted when the word matched the preceding target word, whereas slowed lexical decisions to probe target words resulted when the word matched the preceding ignored nontarget word. In the bilingual (English-Spanish) experiment, between-language, rather than within-language, priming manipulations were used. Although the ignored repetition negative priming effect replicated across languages, cross-language attended repetition positive priming did not. This dissociation of priming effects in the inter- versus intralanguage priming conditions contradicts episodic retrieval accounts of negative priming that deny the existence of selective inhibitory processes. On the other hand, these results support an extension of inhibition-based accounts of negative priming, because they indicate that inhibition can operate at two levels of abstraction--local word and global language--simultaneously.
SN  - 0090-502X
AD  - National Institute of Mental Health, Bethesda, Maryland
U2  - PMID: 10586580.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Wood, Timothy I
AU  - Griffith, Kevin L
AU  - Fawcett, William P
AU  - Jair, Kam-Wing
AU  - Schneider, Thomas D
AU  - Wolf, Richard E
T1  - Interdependence of the position and orientation of SoxS binding sites in the transcriptional activation of the class I subset of Escherichia coli superoxide-inducible promoters.
JO  - Molecular Microbiology
JF  - Molecular Microbiology
Y1  - 1999/11//
VL  - 34
IS  - 3
M3  - Article
SP  - 414
EP  - 430
PB  - Wiley-Blackwell
SN  - 0950382X
AB  - SoxS is the direct transcriptional activator of the member genes of the Escherichia coli superoxide regulon. At class I SoxS-dependent promoters, e.g. zwf and fpr , whose SoxS binding sites (‘soxbox’) lie upstream of the -35 region of the promoter, activation requires the C-terminal domain of the RNA polymerase α-subunit, while at class II SoxS-dependent promoters, e.g. fumC and micF , whose binding sites overlap the -35 region, activation is independent of the α-CTD. To determine whether SoxS activation of its class I promoters shows the same helical phase-dependent spacing requirement as class I promoters activated by catabolite gene activator protein, we increased the 7 bp distance between the 20 bp zwf soxbox and the zwf -35 promoter hexamer by 5 bp and 11 bp, and we decreased the 15 bp distance between the 20 bp fpr soxbox and the fpr -35 promoter hexamer by the same amounts. In both cases, displacement of the binding site by a half or full turn of the DNA helix prevented transcriptional activation. With constructs containing the binding site of one gene fused to the promoter of the other, we demonstrated that the positional requirements are a function of the specific binding site, not the promoter. Supposing that opposite orientation of the SoxS binding site at the two promoters might account for the positional requirements, we placed the zwf and fpr soxboxes in the reverse orientation at the various positions upstream of the promoters and determined the effect of orientation on transcription activation. We found that reversing the orientation of the zwf binding site converts its positional requirement to that of the fpr binding site in its normal orientation, and vice versa. Analysis by molecular information theory of DNA sequences known to bind SoxS in vitro is consistent with the opposite orientation of the zwf and fpr soxboxes. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Binding sites (Biochemistry)
KW  - Escherichia coli
KW  - Genetic transcription
N1  - Accession Number: 5606737; Wood, Timothy I 1; Griffith, Kevin L 1; Fawcett, William P 1; Jair, Kam-Wing 1; Schneider, Thomas D 2; Wolf, Richard E 1; Affiliations: 1: Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, 21250, USA,; 2: Laboratory of Experimental and Computational Biology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA; Issue Info: Nov99, Vol. 34 Issue 3, p414; Thesaurus Term: Binding sites (Biochemistry); Thesaurus Term: Escherichia coli; Subject Term: Genetic transcription; Number of Pages: 17p; Illustrations: 8 Diagrams, 3 Charts, 2 Graphs; Document Type: Article
L3  - 10.1046/j.1365-2958.1999.01598.x
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Santostefano, Michael J.
AU  - Richardson, Vicki M.
AU  - Walker, Nigel J.
AU  - Blanton, Joshua
AU  - Lindros, Kai O.
AU  - Lucier, George W.
AU  - Alcasey, Sattar K.
AU  - Birnbaum, Linda S.
T1  - Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/11//
VL  - 52
IS  - 1
M3  - Article
SP  - 9
EP  - 19
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suggest a differential sensitivity of liver cell types to the induction of cytochrome P450 gene expression, and that the induction of hepatic protein CYP1A2 causes sequestration of TCDD. In addition, immunolocalization of hepatic CYP1A1/1B1/1A2 proteins is not uniform after exposure to TCDD. In addition, immunolocalization of hepatic CYP1A1/1B1/1A2 proteins is not uniform after exposure to TCDD. The mechanism for the regio-specific induction of hepatic P450s by TCDD is unknown, but may involve the differential distribution of participants in the AhR-mediated pathway and/or regional P450 isozymes, as well as, non-uniform distribution/sequestration of TCDD. Therefore, this study examined the effects of TCDD in unfractionated, centrilobular and periportal hepatocytes isolated from female Sprague-Dawley rats acutely exposed (3 days) to a single oral dose of 0.01-10.0 μg [3H]TCDD/kg. A dose-dependent increase in concentration of TCDD was accompanied by a dose-dependent increase in CYP1A1, CYP1A2, and CYP1B1 mRNA expression and associated enzymes in all liver-cell populations. Centrilobular hepatocytes showed a 2.7- to 4.5-fold higher concentration of TCDD as compared to the periportal hepatocytes at doses up to 0.3 μg TCDD/kg. Furthermore, centrilobular hepatocytes showed an elevated concentration of induced CYP1A2 and CYP1B1 mRNA as compared to periportal hepatocytes within the 0.01- and 0.3-μg TCDD/kg-treatment groups. This is the first study to demonstrate that a dose-dependent difference in distribution of TCDD exists between centrilobular and periportal cells that might be related to regional differences in P450 induction. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Tetrachlorodibenzodioxin
KW  - Cytochrome P-450
KW  - Liver cells
KW  - Proteins
KW  - Gene expression
KW  - 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
KW  - 2;3;7;8-tetrachlorodibenzo-p-dioxin (TCDD)
KW  - cytochromes P450
KW  - cytochromes P450.
KW  - hepatocyte
N1  - Accession Number: 44405836; Santostefano, Michael J. 1; Email Address: santostefano.michael@epamail.epa.gov; Richardson, Vicki M. 2; Walker, Nigel J. 3; Blanton, Joshua 2; Lindros, Kai O. 4; Lucier, George W. 3; Alcasey, Sattar K. 2; Birnbaum, Linda S. 2; Affiliations: 1: Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina; 2: U.S. Environmental Protection Agency (USEPA), National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, Research Triangle Park, North Carolina; 3: Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina; 4: National Public Health Institute, Alcohol Research Center, Helsinki, Finland; Issue Info: Nov1999, Vol. 52 Issue 1, p9; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Cytochrome P-450; Subject Term: Liver cells; Subject Term: Proteins; Subject Term: Gene expression; Author-Supplied Keyword: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); Author-Supplied Keyword: 2;3;7;8-tetrachlorodibenzo-p-dioxin (TCDD); Author-Supplied Keyword: cytochromes P450; Author-Supplied Keyword: cytochromes P450.; Author-Supplied Keyword: hepatocyte; Number of Pages: 11p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Chapin, Robert E.
AU  - Delaney, Julie
AU  - Wang, Yefan
AU  - Lanning, Lynda
AU  - Davis, Barbara
AU  - Collins, Brad
AU  - Mintz, Nicki
AU  - Wolfe, Gary
T1  - The effects of 4-nonylphenol in rats: a multigeneration reproduction study.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/11//
VL  - 52
IS  - 1
M3  - Article
SP  - 80
EP  - 91
PB  - Oxford University Press / USA
SN  - 10966080
AB  - The alkylphenol breakdown products of aklylphenol ethoxylates have been shown in in vitro studies to be weakly estrogenic, but few in vivo data address this issue in mammals. Because estrogens have been found to be most potent during developmental/perinatal exposures, this study maximized developmental exposure to nonylphenol (NP) by treating 3.5 generations of Sprague-Dawley rats to NP in diet at 200, 650, and 2000 ppm to determine the range and severity of any toxicity. Dose rate was higher for younger rats; calculated dose ranges were 9-35, 30-100, and 100-350 mg/kg/d for the low (200NP), middle (650NP), and high (2000NP) dose groups, respectively. There were adult (F0, F1, F2) and postnatal day (pnd) 21 (F1, F2, F3) necropsies; the oldest F3 rats were killed on pnd 55-58. Body weight gain was reduced by 8-10% in the 650NP and 2000NP groups. Vaginal opening was accelerated by ≈ 2 days (650NP and ≈ 6 days (2000NP) in F1, F2, and F3 generations. Uterine weights at pnd 21 were increased in 650NP (14%) and 2000NP (50%) F1 females, but not in other generations. Testis descent, anogenital distance, and preputial separation were not consistently changed. No consistent changes were seen in pup number, weight or viability, litter indices, or other functional reproductive measures. Relative ovary weight in F2 adults was decreased at 650NP and 2000NP by 12%; relative ovary was unchanged in other generations. Follicle counts were unchanged in F2 adults. Sperm indices, including CASA measures, were unchanged in F0 and F1 males. In F2 rats, epididymal sperm density was reduced by 8% and 13% at 650NP and 2000NP, respectively. Testicular spermatid count was reduced by 13% in 2000NP F2 males; testis and epididymis weights were unchanged. Erosion of gastric and duodenal mucosa was monitored grossly and microscopically, and never found. Kidney weights were increased in 650NP and 2000NP males, and renal medullary tubular dilatation and cyst formation were noted in all generations of males, and often at the lowest dose tested. These data show that NP had limited effects on the reproductive system in the presence of measurable nephrotoxicity. The F2 sperm effects are either statistical/biological 'noise', or imply heretofore unknown pharmacokinetics or toxicodynamics. These sperm data should be interpreted cautiously until the findings are repeated. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Phenols
KW  - Estrogen
KW  - Nonylphenol
KW  - Pharmacokinetics
KW  - Duodenum
KW  - alkyphenols
KW  - gestational exposure
KW  - multigeneration
KW  - nonylphenol ethoxylate
KW  - reproduction study
N1  - Accession Number: 44405844; Chapin, Robert E. 1; Email Address: chapin@niehs.nih.gov; Delaney, Julie 2; Wang, Yefan 3; Lanning, Lynda 2; Davis, Barbara 1; Collins, Brad 1; Mintz, Nicki 4; Wolfe, Gary 3; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Pathology Associates International, Frederick, Maryland 21701; 3: R.O.W. Sciences, Gaithersburg, Maryland 20878; 4: Analytical Sciences, Inc., Durham, North Carolina 27713; Issue Info: Nov1999, Vol. 52 Issue 1, p80; Thesaurus Term: Phenols; Subject Term: Estrogen; Subject Term: Nonylphenol; Subject Term: Pharmacokinetics; Subject Term: Duodenum; Author-Supplied Keyword: alkyphenols; Author-Supplied Keyword: gestational exposure; Author-Supplied Keyword: multigeneration; Author-Supplied Keyword: nonylphenol ethoxylate; Author-Supplied Keyword: reproduction study; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2015-43882-038
AN  - 2015-43882-038
AU  - Chen, Ren-Wu
AU  - Saunders, Paul A.
AU  - Wei, Huafeng
AU  - Li, Zhuangwu
AU  - Seth, Prem
AU  - Chuang, De-Maw
T1  - Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/11//
VL  - 19
IS  - 21
SP  - 9654
EP  - 9662
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Chuang, De-Maw, Section on Molecular Neurobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3N212, 10 Center Drive, MSC 1272, Bethesda, MD, US, 20892-1272
N1  - Accession Number: 2015-43882-038. PMID: 10531467 Partial author list: First Author & Affiliation: Chen, Ren-Wu; Section on Molecular Neurobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20160328. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Apoptosis; Dehydrogenases; Mice; Granule Cells; mRNA. Minor Descriptor: Genes. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 1999. Publication History: Accepted Date: Aug 23, 1999; Revised Date: Aug 23, 1999; First Submitted Date: Apr 2, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - We recently reported that cytosine arabinoside (AraC)-induced apoptosis of cerebellar neurons involves the overexpression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The present study was undertaken to investigate whether p53 and/or Bax overexpression participates in the AraC-induced apoptosis of cerebellar granule cells and, if so, the relationship between p53 induction and GAPDH overexpression in these cells. AraC-induced apoptosis of cerebellar granule cells was preceded by an increase in levels of p53 mRNA and protein detected between 1 and 8 hr after treatment. The mRNA level for a p53 target gene, Bax, was also increased. The increase in GAPDH mRNA lasted longer than that of either p53 or Bax, and the level of GAPDH protein in the particulate fraction increased after induction of GAPDH mRNA. The antisense oligonucleotide to p53 protected granule cells from AraC-induced chromatin condensation, internucleosomal cleavage, and apoptotic death. The inhibition of p53 expression by the p53 antisense oligonucleotide not only blocked the expression of Bax but also partially suppressed the increased GAPDH mRNA and protein levels. Conversely, the suppression of GAPDH expression and subsequent attenuation of apoptosis of granule cells by GAPDH antisense oligonucleotide did not influence the expression of p53 or Bax. Cerebellar granule cells prepared from p53 knock-out mice were resistant to AraC toxicity, and the p53 gene knock-out suppressed AraC-upregulated GAPDH expression. Moreover, infection of PC12 cells with an adenoviral vector containing p53 gene dramatically increased GAPDH expression and triggered cell apoptosis. These results suggest that AraC-induced apoptosis of cerebellar granule cells involves the expression of both GAPDH and p53 and that, similar to Bax, GAPDH is upregulated by p53 after exposure to the apoptotic insult. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - p53
KW  - GAPDH
KW  - cerebellar granule cell
KW  - PC12
KW  - cytosine arabinoside
KW  - apoptosis
KW  - adenovirus
KW  - 1999
KW  - Apoptosis
KW  - Dehydrogenases
KW  - Mice
KW  - Granule Cells
KW  - mRNA
KW  - Genes
KW  - 1999
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-43882-038&site=ehost-live&scope=site
UR  - chuang@helix.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2014-34674-011
AN  - 2014-34674-011
AU  - Bordin, Paolo
AU  - Da Col, Paolo G.
AU  - Peruzzo, Paolo
AU  - Stanta, Giorgio
AU  - Guralnik, Jack M.
AU  - Cattin, Luigi
T1  - Causes of death and clinical diagnostic errors in extreme aged hospitalized people: A retrospective clinical-necropsy survey.
JF  - The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences
JO  - The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences
JA  - J Gerontol A Biol Sci Med Sci
Y1  - 1999/11//
VL  - 54
IS  - 11
SP  - M554
EP  - M559
CY  - United Kingdom
PB  - Oxford University Press
SN  - 1079-5006
SN  - 1758-535X
AD  - Bordin, Paolo, Istituto di Clinica Medica, Ospedale di Cattinara, Strada di Fiume 447, 34149, Trieste, Italy
N1  - Accession Number: 2014-34674-011. PMID: 10619317 Other Journal Title: Journal of Gerontology. Partial author list: First Author & Affiliation: Bordin, Paolo; Istitutodi Clinica Medica, University of Trieste, Trieste, Italy. Other Publishers: Gerontological Society of America. Release Date: 20160912. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Myocardial Infarctions; Neoplasms; Respiratory Tract Disorders. Minor Descriptor: Death and Dying; Diagnosis. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. Page Count: 6. Issue Publication Date: Nov, 1999. Publication History: Accepted Date: Feb 2, 1999; First Submitted Date: Aug 21, 1998. Copyright Statement: The Gerontological Society of America. 1999. 
AB  - Background: There are little data on causes of death in extreme aged. We compared, using autopsy findings, main cause of death, overall disease status, and accuracy rate of clinical diagnoses in extreme aged and persons dying at younger ages. Methods: We reviewed the complete clinical and autopsy records of 114 consecutive inpatients (97 women, 17 men, age range 97–106, mean 99, median 98) who died in Trieste, Italy, and represented 99% of all extreme-aged person deaths in the hospital and 70% in the area. The control group included 151 patients (66 women, 85 men, age range 65–74, mean 70, median 70) who died during the same period in that hospital. Results: Vascular and respiratory diseases together caused 84% of deaths in extreme aged. The main causes of death were pneumonia (n = 40, 35%), pulmonary embolism (n = 16, 14%), stroke (n = 12, 11%), and myocardial infarction (n = 8,7%). Cancer was responsible for 6% (7/114) of deaths in extreme aged and 42% (64/151) in the control group. In 5% of extreme aged, autopsy findings did not explain death. The premortem diagnostic accuracy rate for clinical diagnoses was good in 44% of extreme aged, sufficient in 18%, poor in 28%, and not evaluable in 10%, and was significantly different from controls. Pneumonia, pulmonary embolism, and myocardial infarction were markedly underestimated by clinicians in both groups. Conclusions: Extreme aged die mainly of cardiovascular and respiratory diseases and, in most cases, of acute events. Senescence is a rare cause of death. Death from cancer is substantially lower than in persons dying at younger ages. In contrast to no autopsy studies, most extreme aged in our study were found to have specific diseases that explained their deaths. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - respiratory diseases
KW  - autopsy records
KW  - pulmonary embolism
KW  - myocardial infarction
KW  - cancers
KW  - 1999
KW  - Myocardial Infarctions
KW  - Neoplasms
KW  - Respiratory Tract Disorders
KW  - Death and Dying
KW  - Diagnosis
KW  - 1999
DO  - 10.1093/gerona/54.11.M554
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UR  - paoli@mail.rodax.it
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43884-040
AN  - 2015-43884-040
AU  - Kajimura, Naofumi
AU  - Uchiyama, Makoto
AU  - Takayama, Yutaka
AU  - Uchida, Sunao
AU  - Uema, Takeshi
AU  - Kato, Masaaki
AU  - Sekimoto, Masanori
AU  - Watanabe, Tsuyoshi
AU  - Nakajima, Toru
AU  - Horikoshi, Satoru
AU  - Ogawa, Kenichi
AU  - Nishikawa, Masami
AU  - Hiroki, Masahiko
AU  - Kudo, Yoshihisa
AU  - Matsuda, Hiroshi
AU  - Okawa, Masako
AU  - Takahashi, Kiyohisa
T1  - Activity of midbrain reticular formation and neocortex during the progression of human non-rapid eye movement sleep.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/11//
VL  - 19
IS  - 22
SP  - 10065
EP  - 10073
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Kajimura, Naofumi, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo, Japan
N1  - Accession Number: 2015-43884-040. PMID: 10559414 Partial author list: First Author & Affiliation: Kajimura, Naofumi; National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan. Release Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Mesencephalon; NREM Sleep. Minor Descriptor: Cerebral Blood Flow. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 1999. Publication History: Accepted Date: Sep 3, 1999; Revised Date: Aug 2, 1999; First Submitted Date: May 17, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - To clarify the neural correlates and brain activity during the progression of human non-rapid eye movement (NREM) sleep, we examined the absolute regional cerebral blood flow (rCBF) during light and deep NREM sleep and during wakefulness in normal humans using positron emission tomography with H₂ ¹⁵O. Relative changes in rCBF during light and deep NREM sleep in comparison to the rCBF during wakefulness were also analyzed. During light NREM sleep, the rCBF in the midbrain, in contrast to that in the pons and thalamic nuclei, did not decrease when compared to that during wakefulness, whereas rCBF decreased in the left medial frontal gyrus, left inferior frontal gyrus, and left inferior parietal gyrus of the neocortex. During deep NREM sleep, the rCBF in the midbrain tegmentum decreased, and there was a marked and bilateral decrease in the rCBF in all neocortical regions except for the perirolandic areas and the occipital lobe. There have been three groups of brain structures, each representing one type of deactivation during the progression of NREM sleep. The activity of the midbrain reticular formation is maintained during light NREM sleep and therefore represents a key distinguishing characteristic between light and deep NREM sleep. Selective deactivation of heteromodal association cortices, including those related to language, occurs with increasingly deep NREM sleep, which supports the recent theory that sleep is not a global, but it is a local process of the brain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - NREM sleep
KW  - positron emission tomography
KW  - cerebral blood flow
KW  - midbrain reticular formation
KW  - ascending reticular activating system
KW  - selective deactivation
KW  - heteromodal association cortex
KW  - 1999
KW  - Brain
KW  - Mesencephalon
KW  - NREM Sleep
KW  - Cerebral Blood Flow
KW  - 1999
U1  - Sponsor: Science and Technology Agency. Recipients: No recipient indicated
U1  - Sponsor: Ministry of Education, Science, and Culture. Recipients: No recipient indicated
U1  - Sponsor: Ministry of Health and Welfare of Japan, Japan. Recipients: No recipient indicated
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UR  - kajimura@sa2.so-net.ne.jp
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-43884-043
AN  - 2015-43884-043
AU  - Deng, Xiaolin
AU  - Ladenheim, Bruce
AU  - Tsao, Li-I
AU  - Cadet, Jean Lud
T1  - Null mutation of c-fos causes exacerbation of methamphetamine-induced neurotoxicity.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/11//
VL  - 19
IS  - 22
SP  - 10107
EP  - 10115
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Cadet, Jean Lud, Molecular Neuropsychiatry Section, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD, US, 21224
N1  - Accession Number: 2015-43884-043. PMID: 10559418 Partial author list: First Author & Affiliation: Deng, Xiaolin; Molecular Neuropsychiatry Section, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, US. Release Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Methamphetamine; Mutations; Neurotoxicity. Minor Descriptor: Genes; Mice; Primates (Nonhuman); Immediate Early Genes; Oxidative Stress. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 1999. Publication History: Accepted Date: Aug 25, 1999; Revised Date: Aug 25, 1999; First Submitted Date: Apr 28, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Methamphetamine neurotoxicity has been demonstrated in rodents and nonhuman primates. These neurotoxic effects may be associated with mechanisms involved in oxidative stress and the activation of immediate early genes (IEG). It is not clear, however, whether these IEG responses are involved in a methamphetamine-induced toxic cascade or in protective mechanisms against the deleterious effects of the drug. As a first step toward clarifying this issue further, the present study was thus undertaken to assess the toxic effects of methamphetamine in heterozygous and homozygous c-fos knock-out as well as wild-type mice. Administration of methamphetamine caused significant reduction in [¹²⁵I]RTI-121–labeled dopamine uptake sites, dopamine transporter protein, and tyrosine hydroxylase– like immunohistochemistry in the striata of wild-type mice. These decreases were significantly exacerbated in heterozygous and homozygous c-fos knock-out mice, with the homozygous showing greater loss of striatal dopaminergic markers. Moreover, in comparison with wild-type animals, both genotypes of c-fos knock-out mice showed more DNA fragmentation, measured by the number of terminal deoxynucleotidyl transferase–mediated dUTP nick-end–labeled nondopaminergic cells in their cortices and striata. In contrast, wild-type mice treated with methamphetamine demonstrated a greater number of glial fibrillary acidic protein–positive cells than did c-fos knock-out mice. These data suggest that c-fos induction in response to toxic doses of methamphetamine might be involved in protective mechanisms against this drug-induced neurotoxicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - methamphetamine
KW  - neurotoxicity
KW  - c-fos mutant
KW  - glial fibrillary acidic protein
KW  - DNA fragmentation
KW  - cell death
KW  - apoptosis
KW  - 1999
KW  - Methamphetamine
KW  - Mutations
KW  - Neurotoxicity
KW  - Genes
KW  - Mice
KW  - Primates (Nonhuman)
KW  - Immediate Early Genes
KW  - Oxidative Stress
KW  - 1999
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UR  - JCADET@intra.nida.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Whitcup, Scott M.
AU  - Fortin, Eric
AU  - Whitcup, S M
AU  - Fortin, E
AU  - Lindblad, A S
AU  - Griffiths, P
AU  - Metcalf, J A
AU  - Robinson, M R
AU  - Manischewitz, J
AU  - Baird, B
AU  - Perry, C
AU  - Kidd, I M
AU  - Vrabec, T
AU  - Davey, R T Jr
AU  - Falloon, J
AU  - Walker, R E
AU  - Kovacs, J A
AU  - Lane, H C
AU  - Nussenblatt, R B
AU  - Smith, J
T1  - Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis.
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/11/03/
VL  - 282
IS  - 17
M3  - journal article
SP  - 1633
EP  - 1637
SN  - 00987484
AB  - <bold>Context: </bold>Persons with cytomegalovirus (CMV) retinitis and acquired immunodeficiency syndrome (AIDS) have required lifelong anti-CMV therapy to prevent the progression of retinal disease and subsequent loss of vision.<bold>Objective: </bold>To determine whether patients who were taking highly active antiretroviral therapy (HAART) and who had stable CMV retinitis could safely discontinue anti-CMV therapy without reactivation of their retinitis or increase in human immunodeficiency virus (HIV) viral load.<bold>Design: </bold>Prospective nonrandomized interventional trial performed from July 1997 to August 1999.<bold>Setting: </bold>Clinical Center of the National Institutes of Health, Bethesda, Md.<bold>Patients: </bold>Fourteen patients with stable CMV retinitis and HIV infection and CD4+ cell counts higher than 0.1 5 x 10(9)/L and being treated with systemic anti-CMV medications and HAART.<bold>Interventions: </bold>Discontinuation of specific anti-CMV therapy.<bold>Main Outcome Measures: </bold>Reactivation of CMV retinitis, development of extraocular CMV infection, detection of CMV in blood and urine, HIV burden, immunologic function, quality of life, morbidity, and mortality.<bold>Results: </bold>Twelve (89.7%) of 14 patients had evidence of immune recovery uveitis before anti-CMV drugs were discontinued. No patient had reactivation of CMV retinitis or development of extraocular CMV disease during mean follow-up of 16.4 months (range, 8.3-22.0 months) without anti-CMV therapy. Human immunodeficiency viral load remained stable following cessation of anti-CMV medications. Blood and urine assays for CMV were briefly positive in 9 patients but did not predict reactivation of CMV disease. Worsening immune recovery uveitis was associated with a substantial (>3 lines) vision loss in 3 patients.<bold>Conclusions: </bold>Maintenance anti-CMV medications were safely stopped in those patients who had stable CMV retinitis and elevated CD4+ cell counts and who were taking HAART. The study demonstrates that immune recovery following potent antiretroviral therapy is effective in controlling a major opportunistic infection, even in patients with a history of severe immunosuppression. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CYTOMEGALOVIRUS diseases -- Treatment
KW  - RETINITIS pigmentosa
N1  - Accession Number: 2854334; Whitcup, Scott M. Fortin, Eric Whitcup, S M 1 Fortin, E Lindblad, A S Griffiths, P Metcalf, J A Robinson, M R Manischewitz, J Baird, B Perry, C Kidd, I M Vrabec, T Davey, R T Jr Falloon, J Walker, R E Kovacs, J A Lane, H C Nussenblatt, R B Smith, J; Affiliation:  1: The Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1863, USA; Source Info: 11/3/99, Vol. 282 Issue 17, p1633; Subject Term: CYTOMEGALOVIRUS diseases -- Treatment; Subject Term: RETINITIS pigmentosa; Number of Pages: 5p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - SAUNDERS, CAROL A.
AU  - SUGAR, ALAN M.
AU  - THOMPSON, PAUL D.
AU  - WEIJER, CHARLES
AU  - YAES, ROBERT J.
AU  - DICKERT, NEAL
AU  - GRADY, CHRISTINE
T1  - What's the Price of a Research Subject?
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
Y1  - 1999/11/11/
VL  - 341
IS  - 20
M3  - Article
SP  - 1550
EP  - 1552
SN  - 00284793
N1  - Accession Number: 88412326; SAUNDERS, CAROL A. 1 SUGAR, ALAN M. 2 THOMPSON, PAUL D. 3 WEIJER, CHARLES 4 YAES, ROBERT J. DICKERT, NEAL 5 GRADY, CHRISTINE 5; Affiliation:  1: Center for Clinical Research Practice Wellesley, MA 02481  2: Boston University School of Medicine Boston, MA 02118  3: Hartford Hospital Hartford, CT 06102  4: Dalhousie University Faculty of Medicine Halifax, NS B3H 4H7, Canada  5: National Institutes of Health Bethesda, MD 20892; Source Info: 11/11/99, Vol. 341 Issue 20, p1550; Number of Pages: 3p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107100743
T1  - Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion.
AU  - Klebanoff MA
AU  - Levine RJ
AU  - DerSimonian R
AU  - Clemens JD
AU  - Wilkins DG
Y1  - 1999/11/25/
N1  - Accession Number: 107100743. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Ebell M. Does caffeine increase the risk of spontaneous abortion in pregnant women? (EVID BASED PRACT) 2000 Mar; 3 (3): 1-2 insert. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by contract (NO1-HD-7-3262) from the National Institutes of Health. NLM UID: 0255562. 
KW  - Abortion, Spontaneous -- Epidemiology
KW  - Caffeine
KW  - Case Control Studies
KW  - Funding Source
KW  - Odds Ratio
KW  - P-Value
KW  - Analysis of Variance
KW  - T-Tests
KW  - Chi Square Test
KW  - Risk Factors
KW  - Adult
KW  - Pregnancy
KW  - Female
KW  - Human
SP  - 1639
EP  - 1644
JO  - New England Journal of Medicine
JF  - New England Journal of Medicine
JA  - N ENGL J MED
VL  - 341
IS  - 22
CY  - Waltham, Massachusetts
PB  - New England Journal of Medicine
SN  - 0028-4793
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Bldg, Rm 7B03, MSC 7510, Bethesda, MD 20892-7510, or mk90h@nih.gov
U2  - PMID: 10572151.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Zhang, Jun
AU  - Klebanoff, Mark A.
AU  - Zhang, J
AU  - Klebanoff, M A
AU  - Levine, R J
AU  - Puri, M
AU  - Moyer, P
T1  - The puzzling association between smoking and hypertension during pregnancy.
JO  - American Journal of Obstetrics & Gynecology
JF  - American Journal of Obstetrics & Gynecology
Y1  - 1999/12//
VL  - 181
IS  - 6
M3  - journal article
SP  - 1407
EP  - 1413
SN  - 00029378
AB  - <bold>Objective: </bold>The object of this study was to examine the association between maternal smoking and hypertension during pregnancy.<bold>Study Design: </bold>We used data from the Collaborative Perinatal Project, a large prospective cohort study that collected detailed information on blood pressure, proteinuria, smoking, and placental morphologic and histologic characteristics. A total of 9651 healthy primigravid women without chronic hypertension who had been enrolled in the study at the first or second trimester (average 18 weeks' gestation) and had had >/=3 prenatal visits were included. Gestational hypertension was defined as diastolic blood pressure >/=90 mm Hg on 2 occasions from 24 weeks' gestation to 2 weeks post partum. Preeclampsia was defined as gestational hypertension plus >/=2 urine samples containing >/=1+ protein according to dipstick measurement during the same gestational period.<bold>Results: </bold>After we controlled for prepregnancy body mass, age, socioeconomic status, and race, both past smoking and smoking during pregnancy were associated in a dose-response pattern with reduced risks of gestational hypertension and preeclampsia. For women who smoked >/=10 cigarettes/d the relative risks with respect to women who had never smoked were 0.6 (95% confidence interval, 0.4-0.9) for gestational hypertension and 0.5 (95% confidence interval, 0.4-0.7) for preeclampsia. This protective effect was observed both for mild and severe gestational hypertension and for preeclampsia. The more and the longer a woman had smoked previously, the lower was her risk of development of hypertension during pregnancy. This association could not be explained by confounding factors, by changes in placental morphologic or histopathologic characteristics, by maternal net weight gain, or by elevated liver enzyme bioactivity.<bold>Conclusion: </bold>Smoking is associated with a reduced risk of hypertension during pregnancy. The protective effect appears to continue even after cessation of smoking. Further basic research on this issue is warranted. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANCY
KW  - PREGNANT women -- Tobacco use
KW  - HYPERTENSION in pregnancy
KW  - HEALTH
N1  - Accession Number: 2708910; Zhang, Jun; Klebanoff, Mark A.; Zhang, J 1; Klebanoff, M A; Levine, R J; Puri, M; Moyer, P; Source Information: Dec99, Vol. 181 Issue 6, p1407; Subject: PREGNANCY; Subject: PREGNANT women -- Tobacco use; Subject: HYPERTENSION in pregnancy; Subject: HEALTH; Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: journal article
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DP  - EBSCOhost
DB  - hch
ER  - 

TY  - JOUR
AU  - Westergaard, G. C.
AU  - Izard, M. K.
AU  - Drake, J. H.
AU  - Suomi, S. J.
AU  - Higley, J. D.
T1  - Rhesus Macaque (Macaca mulatta ) group formation and housing: Wounding and reproduction in a specific pathogen free (SPF) colony.
JO  - American Journal of Primatology
JF  - American Journal of Primatology
Y1  - 1999/12//
VL  - 49
IS  - 4
M3  - Article
SP  - 339
EP  - 347
SN  - 02752565
AB  - In the present report, we examined the effects of group formation strategy and corral design on wounding and reproduction rates in rhesus macaques. Specifically, we examined group formation using a staged strategy, in which small groups of animals were introduced incrementally over a period of weeks, and a rapid formation strategy, in which all animals were introduced in 1 day. We also examined group formation using a divided corral design that facilitated visual and social separation of individuals, and an undivided corral design that did not facilitate visual or social separation. Dependent measures were wounding and reproductive rates over each of the 2 years that followed group formation. Results indicate that incrementally releasing subgroups of animals, and using a corral design that provides for visual and social separation of individuals, are effective strategies for reducing rates of traumatic wounding when forming multimale-multifemale rhesus macaque breeding groups. However, it must be noted that differences in formation strategy and corral design did not lead to higher reproductive rates. We conclude that incrementally releasing animals in hierarchical subgroups, and using a divided vs. undivided housing design, reduced intra-group wounding and associated demands on veterinary and animal management resources following formation of rhesus macaque breeding groups. Am. J. Primatol. 49:339–347, 1999. © 1999 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PRIMATES
KW  - RHESUS monkey
KW  - ANIMAL experimentation
KW  - REPRODUCTION
KW  - AGRICULTURE
KW  - GERMFREE animals
N1  - Accession Number: 12214804; Westergaard, G. C. 1,2; Email Address: gwprimate@aol.com Izard, M. K. 3 Drake, J. H. 1 Suomi, S. J. 2 Higley, J. D. 4; Affiliation:  1: Division of Research, LABS of Virginia, Inc., Yemassee, South Carolina  2: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland  3: Division of Primate Breeding and Behavior, LABS of Virginia, Inc., Yemassee, South Carolina  4: Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland; Source Info: Dec99, Vol. 49 Issue 4, p339; Subject Term: PRIMATES; Subject Term: RHESUS monkey; Subject Term: ANIMAL experimentation; Subject Term: REPRODUCTION; Subject Term: AGRICULTURE; Subject Term: GERMFREE animals; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Cameron, Roy
AU  - Brown, K. Stephen
AU  - Best, J. Allan
AU  - Pelkman, Christine L.
AU  - Madill, Cheryl L.
AU  - Manske, Stephen R.
AU  - Payne, M. Elizabeth
T1  - Effectiveness of a Social Influences Smoking Prevention Program as a Function of Provider Type, Training Method, and School Risk.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/12//
VL  - 89
IS  - 12
M3  - Article
SP  - 1827
EP  - 1831
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. This study determined the effect of provider (nurse or teacher) and training method (workshop or self-preparation) on outcomes of a social influences smoking prevention program. Methods. One hundred elementary schools were stratified by school risk score (high risk = high smoking rate among senior students) and assigned randomly to conditions: (1) teacher/self-preparation, (2) teacher/workshop, (3) nurse/self-preparation, (4) nurse/workshop, and (5) control. Intervention occurred in grades 6 to 8. Smoking stares at the end of grade 8 was the primary endpoint variable. Results. Intervention reduced grade 8 smoking rates in high-risk schools (smoking rates of 26.9% in control vs 16.0% in intervention schools) but not in low-risk schools. There were no significant differences in outcome as a function of training method and no significant differences in outcome between teacher-provided and nurse-provided interventions in high- and medium-risk schools. Although nurses achieved better outcomes than did teachers in low-risk schools, neither provider type achieved outcomes superior to the control condition in those schools. Conclusions. Workshop training did not affect outcomes. Teachers and nurses were equally effective providers. Results suggest that programming should target high-risk schools. (Am J Public Health 1999;89:1827-1831) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - SOCIAL influence
KW  - SMOKING -- Prevention
KW  - YOUTH
KW  - ELEMENTARY schools
KW  - ELEMENTARY education
N1  - Accession Number: 2574098; Cameron, Roy 1,2; Email Address: cameron@healthy.uwaterloo.ca Brown, K. Stephen 1,3 Best, J. Allan 4 Pelkman, Christine L. 5 Madill, Cheryl L. 1 Manske, Stephen R. 6 Payne, M. Elizabeth 1; Affiliation:  1: Health Behaviour Research Group, University of Waterloo, Waterloo, Ontario, Canada  2: Department of Health Studies and Gerontology, University of Waterloo, and the Centre for Behavioural Research and Program Evaluation, National Cancer Institute of Canada, Toronto, Ontario  3: Department of Statistics and Actuarial Science, University of Waterloo  4: Department of Health Studies and Gerontology, University of Waterloo, and the Centre for Clinical Epidemiology and Evaluation, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia  5: College of Health and Human Development, Pennsylvania State University, University Park, Pa.  6: Centre for Behavioural Research and Program Evaluation, National Cancer Institute of Canada; Source Info: Dec1999, Vol. 89 Issue 12, p1827; Subject Term: SOCIAL influence; Subject Term: SMOKING -- Prevention; Subject Term: YOUTH; Subject Term: ELEMENTARY schools; Subject Term: ELEMENTARY education; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 4405
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Little, Ruth E.
AU  - Monaghan, Susan C.
AU  - Gladen, Beth C.
AU  - Shkyryak-Nyzhnyk, Zoreslava A.
AU  - Wilcox, Allen J.
T1  - Outcomes of 17137 Pregnancies in 2 Urban Areas of Ukraine.
JO  - American Journal of Public Health
JF  - American Journal of Public Health
Y1  - 1999/12//
VL  - 89
IS  - 12
M3  - Article
SP  - 1832
EP  - 1836
PB  - American Public Health Association
SN  - 00900036
AB  - Objectives. Frequent terminations of pregnancy and high rates of fetal loss have been reported, but not confirmed, in the former eastern bloc. A census of pregnancies in Ukraine, a former eastern bloc country, was conducted to determine the rates of these events. Methods. All pregnancies registered in 2 urban areas were enumerated. During a 19-month period between 1992 and 1994, 17 137 pregnancies and their outcomes were recorded. Results. Sixty percent of the pregnancies were voluntarily terminated, generally before the 13th week. In pregnancies delivered at 20+ weeks, fetal mortality was 29 per 1000, nearly 5 times the rate among Whites in the United States. There was a greater proportion of very early deliveries (20-27 weeks) in Ukraine, as well as higher death rates at all gestational ages. Perinatal mortality was estimated to be 35 per 1000, about 3 times the US rate. Conclusions. This is believed to be the first study in the former eastern bloc to ascertain all of the clinically recognized pregnancies in a specified period and to determine their outcomes. The data document elevated reproductive risks in a former Soviet state. (Am d Public Health. 1999;89: 1832-1836) [ABSTRACT FROM AUTHOR]
AB  - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREGNANCY
KW  - FETAL death
KW  - DELIVERY (Obstetrics)
KW  - PERINATAL death
KW  - INFANT mortality
KW  - UKRAINE
N1  - Accession Number: 2574099; Little, Ruth E. 1; Email Address: little1@niehs.nih.gov Monaghan, Susan C. 2 Gladen, Beth C. 1 Shkyryak-Nyzhnyk, Zoreslava A. 3 Wilcox, Allen J. 1; Affiliation:  1: National Institute of Environmental Health Sciences, Research Triangle Park, NC  2: School of Public Health, University of Illinois, Chicago  3: Institute of Pediatrics, Obstetrics, and Gynecology, Kyiv, Ukraine; Source Info: Dec1999, Vol. 89 Issue 12, p1832; Subject Term: PREGNANCY; Subject Term: FETAL death; Subject Term: DELIVERY (Obstetrics); Subject Term: PERINATAL death; Subject Term: INFANT mortality; Subject Term: UKRAINE; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 4786
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Roberts, Kim P.
AU  - Lamb, Michael E.
AU  - Sternberg, Kathleen J.
T1  - Effects of the timing of postevent information on preschoolers' memories of an event.
JO  - Applied Cognitive Psychology
JF  - Applied Cognitive Psychology
Y1  - 1999/12//
VL  - 13
IS  - 6
M3  - Article
SP  - 541
EP  - 559
PB  - John Wiley & Sons, Inc.
SN  - 08884080
AB  - Few researchers have investigated whether the timing of postevent information affects the accuracy of children's reports of events they have experienced. In this study, four-year-olds dressed up in costumes and had their photographs taken. An unfamiliar adult spoke to the children about the event either a day (immediate condition) or a month (delayed condition) later, providing both accurate and misleading information about the staged event. When questioned five weeks after the event, children in a control group who had not received the review were more inaccurate answering focused questions than children who had been reminded of the event. A review a while after the event but shortly before the interview increased the amount of details recalled and this was not at the expense of accuracy. Misinformation was seldom reported spontaneously, although children in all groups acquiesced to leading questions in line with the misleading suggestions. Copyright © 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Applied Cognitive Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CHILDREN
KW  - PHOTOGRAPHS
KW  - INTERVIEWING
KW  - QUESTIONS & answers
N1  - Accession Number: 11818247; Roberts, Kim P. 1 Lamb, Michael E. 1 Sternberg, Kathleen J. 1; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, USA; Source Info: Dec1999, Vol. 13 Issue 6, p541; Subject Term: CHILDREN; Subject Term: PHOTOGRAPHS; Subject Term: INTERVIEWING; Subject Term: QUESTIONS & answers; Number of Pages: 19p; Illustrations: 3 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107088367
T1  - Guest editorial. What we read.
AU  - Staab EV
Y1  - 1999/12//1999 Dec
N1  - Accession Number: 107088367. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 7708167. 
KW  - Serial Publications
KW  - Medical Literature
KW  - Access to Information
KW  - Technology, Radiologic
SP  - 6
EP  - 6
JO  - Applied Radiology
JF  - Applied Radiology
JA  - APPL RADIOL
VL  - 28
IS  - 12
CY  - Scotch Plains, New Jersey
PB  - Anderson Publishing Ltd.
SN  - 0160-9963
AD  - Acting Diagnostic Radiology Branch Chief, Diagnostic Imaging Program, National Cancer Institute, Rockville, MD
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107093903
T1  - A staged approach to the treatment of Wegener's granulomatosis: induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance.
AU  - Langford CA
AU  - Talar-Williams C
AU  - Barron KS
AU  - Sneller MC
Y1  - 1999/12//
N1  - Accession Number: 107093903. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0370605. 
KW  - Wegener's Granulomatosis -- Drug Therapy
KW  - Cyclophosphamide -- Therapeutic Use
KW  - Glucocorticoids -- Therapeutic Use
KW  - Methotrexate -- Therapeutic Use
KW  - Disease Remission
KW  - Clinical Trials
KW  - Prospective Studies
KW  - Kaplan-Meier Estimator
KW  - Fisher's Exact Test
KW  - Recurrence
KW  - Drug Toxicity
KW  - Methotrexate -- Adverse Effects
KW  - Cyclophosphamide -- Adverse Effects
KW  - Adolescence
KW  - Adult
KW  - Middle Age
KW  - Aged
KW  - Male
KW  - Female
KW  - Human
SP  - 2666
EP  - 2673
JO  - Arthritis & Rheumatism
JF  - Arthritis & Rheumatism
JA  - ARTHRITIS RHEUM
VL  - 42
IS  - 12
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
SN  - 0004-3591
AD  - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892
U2  - PMID: 10616016.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
TY  - GEN
AU  - DeChristoforo, R.;
AU  - Pascal, K.;
AU  - Daniels, C. E.;
T1  - Basic principles of supervision for non-supervisors
CT  - Basic principles of supervision for non-supervisors
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1999/12/01/
VL  - 34
IS  - Dec
SP  - P
EP  - D
AD  - Warren Grant Magnuson Clin. Ctr., Pharm. Dept., NIH, Bldg. 10, Rm. 1N-257, 10 Center Dr. MSC-1196, Bethesda, MD 20892-1196, USA Internet: rdechristo@nih.gov
N1  - Accession Number: 36-13131; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education; Institutional Pharmacy Practice
N2  - Recent pharmacy graduates and residents usually lack the supervisory skills necessary to deal with administrative situations. Pharmacy administrators and an educator from Human Resources Management designed two 3-h training sessions to specifically address this deficiency. The educator presented topics such as motivational theories, leadership, body language, constructive feedback, and active listening. Pharmacy administrators presented problem situations that have arisen over the years. Participants used a role-playing style to deal with each situation. Principles learned in the first session were expected to be applied to the scenarios. At course conclusion, the program was assessed on two levels. Residents will also be surveyed on the usefulness of the scenarios at their exit interview. Results of the evaluations will be presented.
KW  - Practice Interest Areas--Human Resources Management/Staff Development--meeting presentations;
KW  - ASHP meeting abstracts--management training;
KW  - Administration--hospital pharmacy--management training;
KW  - Pharmacy, institutional, hospital--administration--management training;
KW  - Pharmacy services--management--training;
KW  - Administrators--management--training;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Goldspiel, D. R.;
T1  - Cancer drugs of the future
CT  - Cancer drugs of the future
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1999/12/01/
VL  - 34
IS  - Dec
SP  - PI
EP  - 11
AD  - Pharm. Dept., NIH Clinical Center, Bldg. 10, Rm. 1N-257, Bethesda, MD 20892-1196, USA Internet: bgoldspiel@nih.gov
N1  - Accession Number: 36-12972; Language: English; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2  - Scientists are increasing our knowledge about the molecular events and abnormalities that cause a normal cell to transform into a cancer cell, that cause a cancer cell to become chemotherapy resistant, and that cause cancer to become metastatic. Knowing these molecular pathways has led to new antineoplastic agent classes and therapies being tested in the lab and in the clinic. It is well established that oncogenes, tumor suppressor genes, and key DNA repair enzymes play an important role in the malignant process. Knowledge of these gene abnormalities, the enzymes responsible for protein production, and the associated signal pathways allows drugs to be designed that will specifically act on disrupted genes or their proteins. Some drugs acting on these new molecular targets include protein kinase inhibitors, signal transduction inhibitors, and antiangiogenic agents. Antisense technology to control oncogene activation and/or expression is being tested in several clinical trials. Understanding multidrug resistance transport proteins and genes has provided another strategy that investigators have used to create new cancer therapies by combining drug resistance reversal agents with compounds that are already clinically useful and available. Tumor immunology science has undergone revolutionary changes, and efforts toward using biologic therapy to prevent and ontrol cancer growth have increased dramatically over the years. Identifying ways to target tumors with antibodies or receptor agonists linked to potent toxins has resulted in several immunotoxin trials. Tumor-associated antigens have been identified, and this has caused a renewed interest in developing anticancer vaccines. This talk will summarize some of the new anticancer agents and therapies, including protein kinase inhibitors, signal transduction inhibitors, angiogenesis inhibitors, antimetastasis agents, antisense strategies, multidrug resistance reversal compounds and some new biologic therapies, including immunotoxins, antitumor vaccines, and gene therapy. Learning objectives: 1. Provide the rationale for using drug-resistance reversal agents. 2. Discuss the molecular targets that are currently candidates for new drug development. 3. Describe the biologic rationale for constructing immunotoxins and antitumor vaccines. 4. List the strategies used for gene therapy of cancer. Self-assessment questions: True or False: 1. Anticancer drug dose modification is necessary when using some MDR-blocking drugs. 2. Studies have demonstrated that reinfused bone marrow can be a source of relapse in pediatric patients with acute myelogenous leukemia. 3. Tumor stabilization may become an important endpoint in clinical trials for non-cytotoxic anticancer compounds. Answers: 1. T; 2. T; 3. T.
KW  - Neoplasm vaccines--new drugs-;
KW  - ASHP meeting abstracts--neoplasms, new drugs;
KW  - Immunotherapy--neoplasms;
KW  - Gene therapy--neoplasms;
KW  - Drugs--new--neoplasms;
KW  - Antineoplastic agents--resistance--neoplasms;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Figg, W. D.;
T1  - Role of apoptosis in the development of malignancies and the potential as a therapeutic target
CT  - Role of apoptosis in the development of malignancies and the potential as a therapeutic target
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1999/12/01/
VL  - 34
IS  - Dec
SP  - PI
EP  - 52
AD  - National Cancer Institute, Building 10, Room 5AO1, Bethesda, MD 20892, USA Internet: wdfigg@helix.nih.gov
N1  - Accession Number: 36-13019; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2  - Apoptosis is a highly organized physiologic mechanism of destroying injured and abnormal cells, as well as maintaining homeostasis in a multicellular organism. It is important for host survival since it discards unwanted, damaged, and atypical cells. The process is implicated in the continuous regulation of development, differentiation, and homeostasis. In cancer, there is an imbalance between the rate of cell division and cell death. Therefore, there is a positive rate of growth for the tumor. Agents that promote or suppress apoptosis can manipulate these rates and influence the accumulation of neoplastic cells. Pharmacological manipulation of apoptosis represents a novel approach in targeting malignant cells and has far-reaching implications for new directions in cancer therapy. Learning objectives: 1. Understand the importance of P53 and the cellular pathway for inducing apoptosis. 2. Define the key genes that regulate apoptosis. 3. Describe the importance of the apoptotic pathway for cancer treatment, and what agents affect this pathway. Self-assessment questions: Multiple Choice: 1. What is the difference between apoptosis of a cell and necrosis of a cell (which statement is true)? a. Apoptosis is unorganized cell death that does not require metabolic energy. b. Necrosis is chaotic destruction that does not require continued protein or nucleic acid synthesis. c. Necrosis is a highly coordinated specific response in which the cells undergo membrane blebbing. d. Necrotic cells develop uniform dense masses of DNA that are systematically cleaved. 2. Which statement is false about apoptosis? a. Bcl 2 is regarded as a cell death suppressor and survival gene. b. P53 mediate cell cycle arrest in G1 phase in response to DNA damage. c. Bax promotes the activity of bcl-2. d. Both a and b. 3. Most anticancer agents cause cell death by inducing apoptosis in certain cell lines. Which of these classes of agents would you predict to not affect cell growth through this mechanism? a. Alkylating agents. b. Antimicrotubule agents. . Hormonal agents. d. Platinum analogs. e. All of the above affect apoptosis. Answers: 1. b; 2. c; 3. e.
KW  - ASHP meeting abstracts--apoptosis, neoplasms;
KW  - Antineoplastic agents--neoplasms--apoptosis;
KW  - Neoplasms--apoptosis;
KW  - Apoptosis--neoplasms;
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DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
TY  - GEN
AU  - Daniels, C. E.;
AU  - DeChristoforo, R.;
AU  - Benjamin, B. E.;
T1  - Pharmacist credentialing at the NIH Clinical Center
CT  - Pharmacist credentialing at the NIH Clinical Center
JO  - ASHP Midyear Clinical Meeting
JF  - ASHP Midyear Clinical Meeting
Y1  - 1999/12/01/
VL  - 34
IS  - Dec
SP  - CRED
EP  - ED-1
AD  - Warren Grant Magnuson Clin. Ctr., Pharm. Dept., NIH, Bldg. 10, Rm. 1N-257, 10 Center Dr. MSC-1196, Bethesda, MD 20892-1196, USA Internet: cdaniels@nih.gov
N1  - Accession Number: 36-13065; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations; Institutional Pharmacy Practice
N2  - The Joint Commission on Accreditation of Healthcare Organizations requires that all individuals permitted by law and by the hospital to provide patient care services independently in the hospital have delineated clinical privileges. This process (credentialing) for pharmacists at the National Institutes of Health Clinical Center (NIHCC) is described. The Medical Executive Committee designated the Chief of the Pharmacy Department to be the granter of clinical privileges for pharmacists. The Chief Pharmacist established a credentialing committee made up of diverse department representatives to review the staff's applications. A 2-tiered system was used consisting of core and special/supplemental privileges. All registered pharmacists were required to apply for core privileges at a minimum, regardless of department function. Specific credentialing documents will also be presented.
KW  - ASHP meeting abstracts--JCAHO standards;
KW  - Accreditation--hospital pharmacy--JCAHO standards;
KW  - Joint Commission on Accreditation of Healthcare Organizations--standards--hospital pharmacy;
KW  - Standards--Joint Commission on Accreditation of Healthcare Organizations--hospital pharmacy;
KW  - Professional competence--Joint Commission on Accreditation of Healthcare Organizations--standards;
KW  - Quality assurance--hospital pharmacy--JCAHO standards;
KW  - Pharmacy, institutional, hospital--quality assurance--JCAHO standards;
KW  - Administration--hospital pharmacy--JCAHO standards;
KW  - Pharmacy services--quality assurance--JCAHO standards;
KW  - Clinical pharmacy--services--JCAHO standards;
KW  - Patient care--quality assurance--JCAHO standards;
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=36-13065&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - ipa
ER  - 

TY  - JOUR
AU  - Simopoulos, Artemis P
AU  - Leaf, Alexander
AU  - Salem, Norman Salem
T1  - Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids.
JO  - Asia Pacific Journal of Clinical Nutrition
JF  - Asia Pacific Journal of Clinical Nutrition
Y1  - 1999/12//
VL  - 8
IS  - 4
M3  - Article
SP  - 300
EP  - 301
SN  - 09647058
AB  - Highlights the `Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-3 Fatty Acids' in Besthesda, Maryland on April 7 to 9, 1999.  Participants present in the workshop; Topics discussed in the workshop related to nutrition; Discussion on fatty acids and dietary intakes.
KW  - NUTRITION -- Congresses
KW  - CONFERENCES & conventions
KW  - FATTY acids
KW  - OMEGA-3 fatty acids
KW  - MARYLAND
KW  - BETHESDA (Md.)
KW  - UNITED States
N1  - Accession Number: 5278355; Simopoulos, Artemis P 1 Leaf, Alexander 2 Salem, Norman Salem 3; Affiliation:  1: The Center for Genetics, Nutrition and Health, Washington, DC, USA  2: Massachusetts General Hospital, Charlestown, MA, USA  3: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA President, The Center for Genetics, Nutrition and Health, 2001 S Street, NW, Suite 530, Washington, DC 20009, USA. Tel: 1 202 462 5062; Fax: 1 202 462 5241 Email: cgnh@bellatlantic.net; Source Info: Dec1999, Vol. 8 Issue 4, p300; Subject Term: NUTRITION -- Congresses; Subject Term: CONFERENCES & conventions; Subject Term: FATTY acids; Subject Term: OMEGA-3 fatty acids; Subject Term: MARYLAND; Subject Term: BETHESDA (Md.); Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 2p; Document Type: Article
L3  - 10.1046/j.1440-6047.1999.00123.x
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=5278355&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Siahpush, Mohammad
AU  - Singh, Gopal K.
T1  - Social integration and mortality in Australia.
JO  - Australian & New Zealand Journal of Public Health
JF  - Australian & New Zealand Journal of Public Health
Y1  - 1999/12//
VL  - 23
IS  - 6
M3  - Article
SP  - 571
EP  - 578
SN  - 13260200
AB  - This article focuses on the relationship between social integration, as an ecological characteristic of the social environment, and mortality rates in Australia. Five measures of integration have been used: percentage of people living alone; divorce rate; unemployment rate; proportion of people who are discouraged job seekers; and unionization rate. The impact of these measures on standardized death rates due to specific causes as well as all causes combined and on life expectancy have been examined. Bivariate results generally supported the hypothesis that higher levels of social integration is associated with lower levels of mortality and higher levels of life expectancy. The results showed that among indicators of social integration, percentage of people living alone was the only indicator that was associated with all of the mortality measures. The results also showed that among the measures of mortality, the suicide rate was associated with the largest number of integration indicators. Suicide is more sensitive to variations in various dimensions of social integration than other mortality measures such as the cancer death rate, which is affected only by two indicators of integration.
KW  - INTERPERSONAL relations
KW  - UNEMPLOYMENT
KW  - SOCIAL integration
KW  - MORTALITY
KW  - LIFESTYLES
KW  - DIVORCE
KW  - LIFE expectancy
KW  - AUSTRALIA
N1  - Accession Number: 2622372; Siahpush, Mohammad 1; Email Address: M.Siahpush@aw.latrobe.edu.au; Singh, Gopal K. 2; Affiliations: 1: Faculty of Humanities and Social Sciences, La Trobe University Victoria.; 2: National Institutes of Health, National Cancer Institute, United States.; Issue Info: Dec99, Vol. 23 Issue 6, p571; Thesaurus Term: INTERPERSONAL relations; Thesaurus Term: UNEMPLOYMENT; Subject Term: SOCIAL integration; Subject Term: MORTALITY; Subject Term: LIFESTYLES; Subject Term: DIVORCE; Subject Term: LIFE expectancy; Subject: AUSTRALIA; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - buh
ER  - 

TY  - JOUR
AU  - Burns, Barbara J.
AU  - Hoagwood, Kimberly
AU  - Mrazek, Patricia J.
T1  - Effective Treatment for Mental Disorders in Children and Adolescents.
JO  - Clinical Child & Family Psychology Review
JF  - Clinical Child & Family Psychology Review
Y1  - 1999/12//
VL  - 2
IS  - 4
M3  - Article
SP  - 199
EP  - 254
PB  - Springer Science & Business Media B.V.
SN  - 10964037
AB  - As pressure increases for the demonstration of effective treatment for children with mental disorders, it is essential that the field has an understanding of the evidence base. To address this aim, the authors searched the published literature for effective interventions for children and adolescents and organized this review as follows: (1) prevention; (2) traditional forms of treatment, namely outpatient therapy, partial hospitalization, inpatient treatment, and psychopharmacology; (3) intensive comprehensive community-based interventions including case management, home-based treatment, therapeutic foster care, and therapeutic group homes; (4) crisis and support services; and (5) treatment for two prevalent disorders, major depressive disorder and attention-deficit hyperactivity disorder. Strong evidence was found for the treatment of attention-deficit hyperactivity disorder, depression, anxiety, and disruptive behavior disorders. Guidance from the field relevant to moving the evidence-based interventions into real-world clinical practice and further strengthening the research base will also need to address change in policy and clinical training. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Child & Family Psychology Review is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MENTAL illness
KW  - MENTAL health
KW  - CHILDREN -- Health
KW  - TEENAGERS
KW  - ATTENTION-deficit hyperactivity disorder
KW  - child effectiveness research
KW  - child mental health services research
KW  - child mental health treatment
KW  - community-based interventions
KW  - efficacy
N1  - Accession Number: 11307651; Burns, Barbara J. 1 Hoagwood, Kimberly 2 Mrazek, Patricia J. 3; Affiliation:  1: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina  2: Office of the Director, National Institute of Mental Health, Rockville, Maryland  3: Prevention Technologies, LLC, Bethesda, Maryland; Source Info: Dec1999, Vol. 2 Issue 4, p199; Subject Term: MENTAL illness; Subject Term: MENTAL health; Subject Term: CHILDREN -- Health; Subject Term: TEENAGERS; Subject Term: ATTENTION-deficit hyperactivity disorder; Author-Supplied Keyword: child effectiveness research; Author-Supplied Keyword: child mental health services research; Author-Supplied Keyword: child mental health treatment; Author-Supplied Keyword: community-based interventions; Author-Supplied Keyword: efficacy; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 56p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Kimko, H.C.
AU  - Cross, J.T.
AU  - Abernethy, D.R.
T1  - Pharmacokinetics and Clinical Effectiveness of Methylphenidate.
JO  - Clinical Pharmacokinetics
JF  - Clinical Pharmacokinetics
Y1  - 1999/12//
VL  - 37
IS  - 6
M3  - Article
SP  - 457
EP  - 470
PB  - Springer Science & Business Media B.V.
SN  - 03125963
AB  - Methylphenidate is prescribed for over 90% of children in the US diagnosed as having attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use of methylphenidate in ADHD still poses a number of unresolved questions, including its pharmacodynamic characteristics (drug concentration-effect relationship) and the effect of long term treatment on the patient's psychopathology later in life. The objective of this review is to provide an analysis of the pharmacokinetic-pharmacodynamic properties and therapeutic effectiveness of methylphenidate that may help to answer some of these questions. Methylphenidate has 2 chiral centres, but the drug used in therapy comprises only the threo pair of enantiomers. d-threo-Methylphenidate is more potent than the l-enantiomer. Methylphenidate is administered as a racemic mixture that undergoes stereoselective clearance. Methylphenidate is a short-acting stimulant with a duration of action of 1 to 4 hours and a pharmacokinetic half-life of 2 to 3 hours. Maximum drug concentration after oral administration occurs at about 2 hours. Methylphenidate is absorbed well from the gastrointestinal tract and easily passes to the brain. Methylphenidate is efficacious for short term treatment for children with ADHD. Its mechanism of action is not understood, but may be associated with its influence on multiple neurotransmitters, especially the release and reuptake of dopamine in the striatum. There is marked individual variability in the dose-response relationship for methylphenidate, and therefore dosage must be titrated for optimal effect and avoidance of toxicity in each child. It is unclear whether this variability is predominantly pharmacokinetic or pharmacodynamic. If variable stereoselective metabolism occurs clinically, therapeutic drug monitoring of methylphenidate will require the application of chiral assay methods for the analysis of the active component, d-threo-methylphenidate. It is difficult to predict which children will have a favourable response to methylphenidate. Nonetheless, several studies have been published linking the severity of ADHD in children with improved clinical response to methylphenidate. The use of individual single-blind medication trials may be a practical solution to this problem. Additionally, the targeted condition warrants careful consideration, since different conditions (e.g. misbehaviour or poor academic performance) may require different regimens. Further studies of the relationship between the pharmacokinetic and pharmacodynamic properties of methylphenidate are required to allow the development of optimal dosage regimens. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - METHYLPHENIDATE
KW  - ATTENTION-deficit hyperactivity disorder -- Treatment
KW  - PHARMACOKINETICS
KW  - Attention deficit disorders, treatment
KW  - Central stimulants, adverse reactions
KW  - Central stimulants, pharmacokinetics
KW  - Central stimulants, therapeutic use
KW  - Children
KW  - Clinical pharmacokinetics
KW  - Controlled release drugs
KW  - Intravenous
KW  - Methylphenidate, adverse reactions
KW  - Methylphenidate, pharmacokinetics
KW  - Methylphenidate, therapeutic use
KW  - Oral
KW  - Pharmacokinetic pharmacodynamic relationships
KW  - Plasma protein binding
KW  - Reviews on treatment
N1  - Accession Number: 9523693; Kimko, H.C. 1 Cross, J.T. 1 Abernethy, D.R. 2; Affiliation:  1: Department of Pharmacology, Center for Drug Development Science, Georgetown University Medical Center, Washington, DC, USA  2: Laboratory of Clinical Investigation, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA; Source Info: 1999, Vol. 37 Issue 6, p457; Subject Term: METHYLPHENIDATE; Subject Term: ATTENTION-deficit hyperactivity disorder -- Treatment; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: Attention deficit disorders, treatment; Author-Supplied Keyword: Central stimulants, adverse reactions; Author-Supplied Keyword: Central stimulants, pharmacokinetics; Author-Supplied Keyword: Central stimulants, therapeutic use; Author-Supplied Keyword: Children; Author-Supplied Keyword: Clinical pharmacokinetics; Author-Supplied Keyword: Controlled release drugs; Author-Supplied Keyword: Intravenous; Author-Supplied Keyword: Methylphenidate, adverse reactions; Author-Supplied Keyword: Methylphenidate, pharmacokinetics; Author-Supplied Keyword: Methylphenidate, therapeutic use; Author-Supplied Keyword: Oral; Author-Supplied Keyword: Pharmacokinetic pharmacodynamic relationships; Author-Supplied Keyword: Plasma protein binding; Author-Supplied Keyword: Reviews on treatment; Number of Pages: 14p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Yuan, B.-Z.
AU  - Yang, Y.
AU  - Keck-Waggoner, C.L.
AU  - Zimonjic, D.B.
AU  - Thorgeirsson, S.S.
AU  - Popescu, N.C.
T1  - Assignment<FOOTREF>[sup 1] </FOOTREF> and cloning of mouse Arhgap7 to chromosome 8A4–B2, a conserved syntenic region of human chromosome 8p22→p21.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1999/12//
VL  - 87
IS  - 3/4
M3  - Article
SP  - 189
EP  - 190
SN  - 03010171
AB  - This article discusses about assignment and cloning of mouse Arhgap7 to chromosome 8A4-B2, a conserved syntenic region of human chromosome 8p22→ p21. The mouse lambda gt10 cDNA library derived from liver tissue mRNA and the mouse lambda Fix genomic DNA library were screened by full-length human DLC1 cDNA, labeled with 32P-dCTP using a random primer protocol. Lambda DNAs were extracted from positive clones obtained from both library screenings. DNA sequencing of positive clones was completed by primer walking. Mapping data at the end of the article provides information about number of cells examined, precise location, cells with specific signals and gene location. cDNA data provides information about cDNA length, open reading frame and GenBank accession number.
KW  - GENE mapping
KW  - HUMAN chromosomes
KW  - COMPLEMENTARY DNA
KW  - MESSENGER RNA
KW  - NUCLEOTIDE sequence
KW  - GENE libraries
N1  - Accession Number: 12184636; Yuan, B.-Z. 1 Yang, Y. 1 Keck-Waggoner, C.L. 1 Zimonjic, D.B. 1 Thorgeirsson, S.S. 1 Popescu, N.C. 1; Email Address: nicholas_popescu@nih.gov; Affiliation:  1: Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD (USA).; Source Info: Dec99, Vol. 87 Issue 3/4, p189; Subject Term: GENE mapping; Subject Term: HUMAN chromosomes; Subject Term: COMPLEMENTARY DNA; Subject Term: MESSENGER RNA; Subject Term: NUCLEOTIDE sequence; Subject Term: GENE libraries; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000015462
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12184636&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Leach, R.
AU  - Ko, M.
AU  - Krawetz, S.A.
T1  - Assignment<FOOTREF>[sup 1] </FOOTREF> of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization.
JO  - Cytogenetics & Cell Genetics
JF  - Cytogenetics & Cell Genetics
Y1  - 1999/12//
VL  - 87
IS  - 3/4
M3  - Article
SP  - 215
EP  - 216
SN  - 03010171
AB  - This article presents the method of assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization (FISH). APLP2 is a member of a conserved, multifunctional transmembrane glycoprotein superfamily that participates in the activation of the G protein cell transduction system. Other members, include, amyloid-precursor-like protein 1 (APLP 1) and amyloid precursor protein (APP). The latter, located on chromosome 21, has been implicated in Alzheimer's disease. FISH mapping was performed. Figures at the end of the article are traced, which show biotin-labeled cDNA clone R69769 to human metaphase chromosome. At the end of the article results about mapping data are presented.
KW  - GENE mapping
KW  - GLYCOPROTEINS
KW  - COMPLEMENTARY DNA
KW  - HUMAN chromosomes
KW  - FLUORESCENCE in situ hybridization
KW  - ALZHEIMER'S disease
N1  - Accession Number: 12184626; Leach, R. 1,2; Email Address: rleach@wayne.edu Ko, M. 3 Krawetz, S.A. 1,2,4; Affiliation:  1: Department of Obstetrics and Gynecology.  2: C. S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit MI  3: Laboratory of Genetics, National Institute on Aging, NIH, Baltimore MD (USA).  4: Center for Molecular Medicine and Genetics.; Source Info: Dec99, Vol. 87 Issue 3/4, p215; Subject Term: GENE mapping; Subject Term: GLYCOPROTEINS; Subject Term: COMPLEMENTARY DNA; Subject Term: HUMAN chromosomes; Subject Term: FLUORESCENCE in situ hybridization; Subject Term: ALZHEIMER'S disease; Number of Pages: 2p; Document Type: Article
L3  - 10.1159/000015472
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12184626&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bulavin, Dmitry V.
AU  - Saito, Shin'ichi
AU  - Hollander, M. Christine
AU  - Sakaguchi, Kazuyasu
AU  - Anderson, Carl W.
AU  - Appella, Ettore
AU  - Fornace Jr., Albert J.
T1  - Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/12//12/1/99
VL  - 18
IS  - 23
M3  - Article
SP  - 6845
EP  - 6854
SN  - 02614189
AB  - Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway, p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at Ser33 and Ser46, a newly identified site. Mutation of these sites decreased p53-mediated and UV-induced apoptosis, and the reduction correlated with total abrogation of UV-induced phosphorylation on Ser37 and a significant decrease in Serl5 phosphorylation in mutant p53 containing alanine at Ser33 and Ser46. Inhibition of p38 activation after UV irradiation decreased phosphorylation of Ser33, Ser37 and Serl5, and also markedly reduced UV-induced apoptosis in a p53-dependent manner. These results suggest that p38 kinase plays a prominent role in an integrated regulation of N-terminal phosphorylation that regulates p53-mediated apoptosis after UV radiation. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - P53 antioncogene
KW  - PHOSPHORYLATION
KW  - APOPTOSIS
KW  - ULTRAVIOLET radiation
KW  - DNA damage
KW  - MUTATION (Biology)
KW  - apoptosis
KW  - dna damage
KW  - p38
KW  - p53
KW  - phosphorylation
N1  - Accession Number: 13004464; Bulavin, Dmitry V. 1 Saito, Shin'ichi 2 Hollander, M. Christine 1 Sakaguchi, Kazuyasu 2,3 Anderson, Carl W. 4 Appella, Ettore 2 Fornace Jr., Albert J. 1; Email Address: fornace@nih.gov; Affiliation:  1: Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda  2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda  3: Laboratory of Structure-Function Biochemistry, Department of Molecular Science, Kyushu University, Fukuoka, Japan  4: Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA; Source Info: 12/1/99, Vol. 18 Issue 23, p6845; Subject Term: P53 antioncogene; Subject Term: PHOSPHORYLATION; Subject Term: APOPTOSIS; Subject Term: ULTRAVIOLET radiation; Subject Term: DNA damage; Subject Term: MUTATION (Biology); Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: dna damage; Author-Supplied Keyword: p38; Author-Supplied Keyword: p53; Author-Supplied Keyword: phosphorylation; Number of Pages: 10p; Document Type: Article
L3  - 10.1093/emboj/18.23.6845
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004464&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Bristol-Power, Marie M.
AU  - Spinella, Giovanna
T1  - Research on Screening and Diagnosis in Autism: A Work in Progress.
JO  - Journal of Autism & Developmental Disorders
JF  - Journal of Autism & Developmental Disorders
Y1  - 1999/12//
VL  - 29
IS  - 6
M3  - Article
SP  - 435
EP  - 438
PB  - Springer Science & Business Media B.V.
SN  - 15733432
AB  - In June 1998, the National Institutes of Health Autism Coordinating Committee (NIH/ACC) invited representatives of 13 major medical and other professional academies and associations and six national autism parent research organizations to review research data on screening and diagnosis of autism spectrum disorders. Ten review papers and more than 4,000 publications were consulted in this effort. This paper highlights some promising areas for research identified in this process. One of the highest priorities is the search for the ultimate diagnostic indicator, a biological marker(s), for example, genetic, metabolic, immunologic, neurologic, that will distinguish autism unequivocally from other developmental disabilities. In the interim, research on infant screening and diagnosis might lower the threshold age for diagnosis to 8–12 months. The role of sensory-motor disorders in early diagnosis needs further research. Earlier and better diagnosis of co-occurring, potentially treatable disorders, including epileptic and epileptiform disorders, has implications both for diagnosis and treatment. Pharmacogenetic and pharmacogenomic research strategies could help diagnose subtypes and responders versus nonresponders to potential treatments. Better endpoints and outcome measures are needed, including improved procedures for cognitive and neuropsychological testing, more knowledge about verbal and nonverbal communication milestones, and less invasive and more sensitive neuroimaging measures. Critical questions remain regarding regression after apparently normal development, and about possible environmental precipitants. Finally, field trials of the reliability and validity of screening and diagnosis using the newly developed practice guidelines are needed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Autism & Developmental Disorders is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - AUTISM
KW  - DIAGNOSIS
KW  - COGNITION
KW  - NEUROPSYCHOLOGICAL tests
KW  - autism
KW  - diagnosis
N1  - Accession Number: 11305472; Bristol-Power, Marie M. 1; Email Address: BRISTOLM@mail.nih.gov Spinella, Giovanna 2; Affiliation:  1: National Institute of Child Health and Human Development, Bethesda, Maryland  2: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: Dec1999, Vol. 29 Issue 6, p435; Subject Term: AUTISM; Subject Term: DIAGNOSIS; Subject Term: COGNITION; Subject Term: NEUROPSYCHOLOGICAL tests; Author-Supplied Keyword: autism; Author-Supplied Keyword: diagnosis; Number of Pages: 4p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Feerick, Margaret M.
AU  - Haugaard, Jeffrey J.
T1  - Long-Term Effects of Witnessing Marital Violence for Women: The Contribution of Childhood Physical and Sexual Abuse.
JO  - Journal of Family Violence
JF  - Journal of Family Violence
Y1  - 1999/12//
VL  - 14
IS  - 4
M3  - Article
SP  - 377
EP  - 398
PB  - Springer Science & Business Media B.V.
SN  - 08857482
AB  - A sample of 313 college women completed a questionnaire about experiences with violence in childhood and adulthood and adult adjustment and relationship functioning. Nine percent of the women reported having witnessed some type of physical conflict between their parents. Witnessing marital violence was associated with other family mental health risks, childhood physical and sexual abuse, and adult physical assaults by strangers. Women who witnessed marital violence reported more symptoms of posttraumatic stress disorder than other women, after family background and abuse variables were accounted for. Significant interactions between witnessing marital violence and childhood physical abuse were observed for measures of social avoidance and predictability in partner relationships, indicating that the effects of witnessing marital violence depended on the presence of childhood abuse. Implications of these results for research and interventions are discussed. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Family Violence is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - OFFENSES against the person
KW  - WOMEN college students
KW  - WOMEN -- Crimes against
KW  - VICTIMS of family violence
KW  - WIFE abuse
KW  - MARITAL violence
KW  - CHILD abuse
KW  - adjustment
KW  - child abuse
KW  - effects on children
KW  - marital violence
N1  - Accession Number: 2614164; Feerick, Margaret M. 1 Haugaard, Jeffrey J. 2; Affiliation:  1: Child Development and Behavior Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B05, MSC 7510, Bethesda, Maryland 20892-7510  2: Department of Human Development, Cornell University, Ithaca, New York; Source Info: Dec99, Vol. 14 Issue 4, p377; Subject Term: OFFENSES against the person; Subject Term: WOMEN college students; Subject Term: WOMEN -- Crimes against; Subject Term: VICTIMS of family violence; Subject Term: WIFE abuse; Subject Term: MARITAL violence; Subject Term: CHILD abuse; Author-Supplied Keyword: adjustment; Author-Supplied Keyword: child abuse; Author-Supplied Keyword: effects on children; Author-Supplied Keyword: marital violence; Number of Pages: 22p; Illustrations: 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Glazner, Gordon W.
AU  - Boland, Andre
AU  - Dresse, Albert E.
AU  - Brenneman, Douglas E.
AU  - Gozes, Illana
AU  - Mattson, Mark P.
T1  - Activity-Dependent Neurotrophic Factor Peptide (ADNF9) Protects Neurons Against Oxidative Stress-Induced Death.
JO  - Journal of Neurochemistry
JF  - Journal of Neurochemistry
Y1  - 1999/12//
VL  - 73
IS  - 6
M3  - Article
SP  - 2341
EP  - 2347
PB  - Wiley-Blackwell
SN  - 00223042
AB  - Abstract: Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-d-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - NEUROTROPHINS
KW  - APOPTOSIS
KW  - PREVENTION
KW  - Activity-dependent neurotrophic factor
KW  - Apoptosis
KW  - Neurons
KW  - Reactive oxygen species
KW  - Trophic factor withdrawal
N1  - Accession Number: 4811146; Glazner, Gordon W. 1 Boland, Andre 1,2 Dresse, Albert E. 2 Brenneman, Douglas E. 3 Gozes, Illana 4 Mattson, Mark P. 1; Affiliation:  1: Sanders-Brown Research Center on Aging and Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky  2: Institute of Pathology, University of Liège, Liège, Belgium  3: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, U.S.A.  4: Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Source Info: Dec99, Vol. 73 Issue 6, p2341; Subject Term: NEUROTROPHINS; Subject Term: APOPTOSIS; Subject Term: PREVENTION; Author-Supplied Keyword: Activity-dependent neurotrophic factor; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Neurons; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Trophic factor withdrawal; Number of Pages: 7p; Document Type: Article
L3  - 10.1046/j.1471-4159.1999.0732341.x
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107107266
T1  - Nonsurgical management of the foot and ankle affected by rheumatoid arthritis.
AU  - Shrader JA
Y1  - 1999/12//1999 Dec
N1  - Accession Number: 107107266. Language: English. Entry Date: 20000501. Revision Date: 20150819. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7908150. 
KW  - Foot -- Pathology
KW  - Ankle -- Pathology
KW  - Arthritis, Rheumatoid -- Therapy
KW  - Arthritis -- Education
KW  - Therapeutic Exercise
KW  - Orthoses
KW  - Arthritis, Rheumatoid -- Symptoms
KW  - Foot Deformities
KW  - Gait
KW  - Arthritis, Rheumatoid -- Diagnosis
KW  - Shoes
SP  - 703
EP  - 717
JO  - Journal of Orthopaedic & Sports Physical Therapy
JF  - Journal of Orthopaedic & Sports Physical Therapy
JA  - J ORTHOP SPORTS PHYS THER
VL  - 29
IS  - 12
CY  - La Crosse, Wisconsin
PB  - American Physical Therapy Association, Orthopaedic Section
AB  - Rheumatoid arthritis frequently affects foot and ankle function, leading to pain, difficulty with ambulation, and disability. The purpose of this article is to describe common foot and ankle deformities associated with rheumatoid arthritis and present state-of-the-art nonsurgical management strategies. Physical impairments thought to be commonly associated with limitations of function and practical interventions for alleviating those impairments or reducing the impact of the impairment on ambulation are identified. Examples of rehabilitation interventions discussed include prescription footwear, custom and premolded foot orthoses, hindfoot orthoses, ankle-foot orthoses, shoe modifications, therapeutic exercises, and patient education. Early and aggressive attempts at prevention, delay, or correction of foot and ankle pathomechanics related to rheumatoid arthritis may play a key role in helping patients maintain an active ambulatory lifestyle.
SN  - 0190-6011
AD  - Senior Physical Therapist, Warren Grant Magnuson Clinical Center, Rehabilitation Medicine Department, Physical Therapy Section, National Institutes of Health, Building 10, Room 6S235, 10 Center Drive, MSC 1604, Bethesda, MD 20892-1604. E-mail: Joseph_Shrader@nih.gov
U2  - PMID: 10612068.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - McCrae, Robert R.
T1  - Mainstream Personality Psychology and the Study of Religion.
JO  - Journal of Personality
JF  - Journal of Personality
Y1  - 1999/12//
VL  - 67
IS  - 6
M3  - Article
SP  - 1209
EP  - 1218
PB  - Wiley-Blackwell
SN  - 00223506
AB  - In this commentary, I make some general observations about the study of personality and religion and some specific comments about individual articles from the perspective of contemporary personality psychology. Most of the authors represented here treat religion as a domain of human experience and behavior that can be understood in terms of familiar personality principles and processes. I therefore urge greater attention to the Five-Factor Model of personality traits, especially Openness to Experience, in understanding religious phenomena. Mainstream psychologists, including longitudinal researchers, behavior geneticists, and epidemiologists, should consider the inclusion of religious variables in their research designs. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PERSONALITY
KW  - PSYCHOLOGY
KW  - RELIGION
KW  - PSYCHOLOGISTS
KW  - GENETICISTS
N1  - Accession Number: 2697433; McCrae, Robert R. 1; Affiliation:  1: Gerontology Research Center, National Institute on Aging, NIH, Baltimore, Maryland; Source Info: Dec99, Vol. 67 Issue 6, p1209; Subject Term: PERSONALITY; Subject Term: PSYCHOLOGY; Subject Term: RELIGION; Subject Term: PSYCHOLOGISTS; Subject Term: GENETICISTS; Number of Pages: 10p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107104738
T1  - Streptococcus mutans, early childhood caries and new opportunities.
AU  - Slavkin HC
Y1  - 1999/12//
N1  - Accession Number: 107104738. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060. 
KW  - Dental Caries -- Prevention and Control -- In Infancy and Childhood
KW  - Dental Caries -- Microbiology -- In Infancy and Childhood
KW  - Streptococcus
KW  - Antibiotics -- Therapeutic Use
KW  - Bottle Feeding -- Adverse Effects
KW  - Dental Caries -- Etiology
KW  - Dental Caries -- Epidemiology
KW  - Disease Transmission, Vertical
KW  - Emergency Nurses Association
KW  - Family Health
KW  - Fluoridation
KW  - Infant
KW  - Child, Preschool
KW  - Child
KW  - Biofilms
KW  - United States
SP  - 1787
EP  - 1792
JO  - Journal of the American Dental Association (JADA)
JF  - Journal of the American Dental Association (JADA)
JA  - J AM DENT ASSOC
VL  - 130
IS  - 12
CY  - Chicago, Illinois
PB  - American Dental Association
SN  - 0002-8177
AD  - National Institute of Dental and Craniofacial Research, 31 Center Drive, MSC 2290, Building 31, Room 2C39, Bethesda, Md 20892-2290
U2  - PMID: 10599184.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Baum, Bruce J
T1  - Crowning achievements in dentistry.
JO  - Lancet
JF  - Lancet
Y1  - 1999/12//Dec1999 Supplement 4
VL  - 354
M3  - Article
SP  - SIV12
EP  - SIV12
PB  - Lancet
SN  - 00995355
AB  - This article presents the author's comments about the development of dentistry. The author says that at the close of the 20th century, dentistry is a profession based on scientific principles. He says that this evolution has coincided with a remarkable improvement in dental public health in countries with strong academic dental programs. He says that periodontal diseases can be minimized with excellent oral hygiene and chemotherapeutic agents. Oral medical disorders are commonly neglected because neither dentists nor physicians take responsibility for them. The author says that dentistry is becoming more biomedical and academic in outlook.
KW  - DENTISTRY
KW  - DENTAL care
KW  - PUBLIC health
KW  - PERIODONTAL disease -- Prevention
KW  - PREVENTIVE dentistry
KW  - DRUG therapy
KW  - DENTISTS
N1  - Accession Number: 20444760; Baum, Bruce J 1; Email Address: BBaum@dir.nidcr.nih.gov; Affiliation:  1: Chief of the gene therapy and therapeutics branch of the National Institute of Dental and Craniofacial Research, USA; Source Info: Dec1999 Supplement 4, Vol. 354, pSIV12; Subject Term: DENTISTRY; Subject Term: DENTAL care; Subject Term: PUBLIC health; Subject Term: PERIODONTAL disease -- Prevention; Subject Term: PREVENTIVE dentistry; Subject Term: DRUG therapy; Subject Term: DENTISTS; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Illustrations: 1 Black and White Photograph; Document Type: Article; Full Text Word Count: 872
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Blackmore-Prince, Cheryl
AU  - Kieke Jr., Burney
AU  - Kugaraj, Krista A.
AU  - Ferré, Cynthia
AU  - Elam-Evans, Laurie D.
AU  - Krulewitch, Cara J.
AU  - Gaudino, James A.
AU  - Overpeck, Mary
T1  - Racial Differences in the Patterns of Singleton Preterm Delivery in the 1988 National Maternal and Infant Health Survey.
JO  - Maternal & Child Health Journal
JF  - Maternal & Child Health Journal
Y1  - 1999/12//
VL  - 3
IS  - 4
M3  - Article
SP  - 189
PB  - Springer Science & Business Media B.V.
SN  - 10927875
AB  - Objectives: To determine if the association between race and preterm delivery would persist when preterm delivery was partitioned into two etiologic pathways. Methods: We evaluated perinatal and obstetrical data from the 1988 National Maternal and Infant Health Survey and classified preterm delivery as spontaneous or medically indicated. Discrete proportional hazard models were fit to assess the risk of preterm delivery for Black women compared with White women adjusting for potential demographic and behavioral confounding variables. Results: Preterm delivery occurred among 17.4% of Black births and 6.7% of White births with a Black versus White unadjusted hazard ratio (HR) of 2.8 (95% CI = 2.4-3.3). The adjusted HR for a medically indicated preterm delivery showed no racial difference in risk (HR = 1.0, 95% CI = 0.4-2.6). However, for spontaneous preterm delivery between 20 and 28 weeks gestation, the Black versus White adjusted hazard ratio (HR) was 4.9 (95% CI = 3.4-7.1). Conclusions: Although we found an increased unadjusted HR for preterm delivery among Black women compared with White women, the nearly fivefold increase in adjusted HR for the extremely preterm births and the absence of a difference for medically indicated preterm delivery was unexpected. Given the differences in the risks of preterm birth between Black and White women, we recommend to continue examining risk factors for preterm delivery after separating spontaneous from medically indicated preterm birth and subdividing preterm delivery by gestational age to shed light on the reasons for the racial disparity. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PREMATURE labor
KW  - RACE
KW  - GESTATIONAL age
KW  - Epidemiology
KW  - gestational age
KW  - infant, premature
KW  - pregnancy outcome
KW  - preterm birth
KW  - race
N1  - Accession Number: 11307810; Blackmore-Prince, Cheryl 1; Email Address: CAB5@CDC.GOV Kieke Jr., Burney 1 Kugaraj, Krista A. 1 Ferré, Cynthia 1 Elam-Evans, Laurie D. 1 Krulewitch, Cara J. 2 Gaudino, James A. 1 Overpeck, Mary 3; Affiliation:  1: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia  2: National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland  3: National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Dec1999, Vol. 3 Issue 4, p189; Subject Term: PREMATURE labor; Subject Term: RACE; Subject Term: GESTATIONAL age; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: gestational age; Author-Supplied Keyword: infant, premature; Author-Supplied Keyword: pregnancy outcome; Author-Supplied Keyword: preterm birth; Author-Supplied Keyword: race; Number of Pages: 9p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107099301
T1  - Obtaining long-term disease specific costs of care: application to Medicare enrollees diagnosed with colorectal cancer.
AU  - Brown ML
AU  - Riley GF
AU  - Potosky AL
AU  - Etzioni RD
Y1  - 1999/12//1999 Dec
N1  - Accession Number: 107099301. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027. 
KW  - Colorectal Neoplasms -- Economics
KW  - Medicare -- Economics
KW  - Health Care Costs
KW  - Kaplan-Meier Estimator
KW  - Descriptive Statistics
KW  - Age Factors
KW  - Severity of Illness
KW  - Neoplasm Staging
KW  - Linear Regression
KW  - Wilcoxon Rank Sum Test
KW  - Confidence Intervals
KW  - P-Value
KW  - Male
KW  - Female
KW  - Aged
KW  - Aged, 80 and Over
KW  - Prospective Studies
KW  - United States
KW  - Chi Square Test
KW  - Statistical Significance
KW  - Human
SP  - 1249
EP  - 1259
JO  - Medical Care
JF  - Medical Care
JA  - MED CARE
VL  - 37
IS  - 12
CY  - Baltimore, Maryland
PB  - Lippincott Williams & Wilkins
SN  - 0025-7079
AD  - Applied Research Program, National Cancer Institute, EPN Room 313, 6130 Executive Blvd., MSC 7344, Bethesda, MD 20892-7344; e-mail: mb53o@nih.gov
U2  - PMID: 10599606.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107083306
T1  - Skin anatomy, physiology, and pathophysiology.
AU  - Wysocki AB
Y1  - 1999/12//1999 Dec
N1  - Accession Number: 107083306. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0042033. 
KW  - Skin -- Anatomy and Histology
KW  - Skin Physiology
KW  - Wound Healing
KW  - Ischemia
KW  - Epidermis
KW  - Immune System
KW  - Dermis
KW  - Wounds and Injuries -- Physiopathology
KW  - Reperfusion Injury
KW  - Wounds and Injuries -- Classification
KW  - Pressure Ulcer -- Classification
KW  - Burns -- Classification
SP  - 777
EP  - 797
JO  - Nursing Clinics of North America
JF  - Nursing Clinics of North America
JA  - NURS CLIN NORTH AM
VL  - 34
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - Human skin is the largest multifunctional organ of the body, and knowledge of its structure and function is essential to clinicians and researchers. The skin has two layers, the epidermis and dermis, separated by a basement membrane zone. It provides protection, sensation, thermoregulation, biochemical/metabolic, and immune functions. Key and emerging concepts important to understanding pathophysiological mechanisms for practicing clinicians are: knowledge of differences between acute and chronic wounds; ability to evaluate depth and extent of injury; understanding stages of healing versus zones of activity; and knowledge of ischemic-reperfusion injury, the skin immune system, cytokines, growth factors and other biomolecules, and matrix synthesis and degradation. These concepts are addressed in this article. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0029-6465
AD  - Wound Healing Laboratory, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, 9 Center Drive, MSC 0967, Building 9, Room 1W125, Bethesda, MD 20892-0967. E-mail: annette_wysocki@nih.gov
U2  - PMID: 10523436.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107088642
T1  - Prevention and treatment of microvascular and neuropathic complications of diabetes.
AU  - Eastman RC
AU  - Garfield SA
Y1  - 1999/12//1999 Dec
N1  - Accession Number: 107088642. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463. 
KW  - Diabetes Mellitus -- Complications
KW  - Diabetic Neuropathies
KW  - Diabetic Retinopathy
KW  - Disease Duration
KW  - Blood Glucose -- Adverse Effects
KW  - Glycemic Control
KW  - Diabetic Neuropathies -- Prevention and Control
KW  - Diabetic Retinopathy -- Prevention and Control
KW  - Risk Factors
SP  - 791
EP  - 807
JO  - Primary Care
JF  - Primary Care
JA  - PRIM CARE
VL  - 26
IS  - 4
CY  - Philadelphia, Pennsylvania
PB  - W B Saunders
AB  - The most important factors that influence development of the eye, kidney, and nerve complications of diabetes are the duration and degree of exposure to hyperglycemia. Hypertension is also very important. The risk of complications appears to be similar for all patients with diabetes; differences in complication rates between patients with type 1 and type 2 diabetes are largely due to differences in duration of diabetes and glycemic control. The benefits of lowering blood sugar are also similar for patients with diabetes, regardless of the type. Significant reductions in complications can be seen with relatively short-term treatment of hyperglycemia. Copyright (c) 1999 by W.B. Saunders Company
SN  - 0095-4543
AD  - National Institutes of Health, NIDDK, Building 31, Room 9A16, 31 Center Dr MSC 2560, Bethesda, MD 20892; e-mail: Eastmand@extra.niddk.nih.gov
U2  - PMID: 10523460.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107082790
T1  - Deciphering the code of life.
AU  - Collins FS
AU  - Jegalian KG
Y1  - 1999/12//
N1  - Accession Number: 107082790. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Consumer Health; USA. NLM UID: 0404400. 
KW  - Human Genome Project
SP  - 86
EP  - 91
JO  - Scientific American
JF  - Scientific American
JA  - SCI AM
VL  - 281
IS  - 6
CY  - New York, New York
PB  - Scientific American
SN  - 0036-8733
AD  - Director, National Institutes of Health's National Human Genome Research Institute (NHGRI)
U2  - PMID: 10614070.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Simon, R.
T1  - The role of statisticians in intervention trials.
JO  - Statistical Methods in Medical Research
JF  - Statistical Methods in Medical Research
Y1  - 1999/12//
VL  - 8
IS  - 4
M3  - journal article
SP  - 281
EP  - 286
PB  - Sage Publications, Ltd.
SN  - 09622802
AB  - The planning, conduct, analysis and reporting of randomized trials to reliably evaluate an intervention create a complex intellectual and logistical endeavour. Success generally requires active collaboration of a well-trained, experienced and committed statistician. A good intervention trial asks an important question, gets a reliable answer and is honestly reported. Many trials fail on one of these components and some of these failures could have been avoided with better statistical involvement. Many subject matter investigators do not understand how to effectively collaborate with statisticians. The objective here is to outline some of the important responsibilities of the statistician in intervention trials. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - STATISTICIANS
KW  - MEDICINE
KW  - PUBLIC health -- United States
KW  - UNITED States
N1  - Accession Number: 4164664; Simon, R. 1; Affiliation:  1: National Cancer Institute, Bethesda, Maryland, USA; Source Info: 1999, Vol. 8 Issue 4, p281; Subject Term: STATISTICIANS; Subject Term: MEDICINE; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 6p; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Waalkes, Michael P.
AU  - Anver, Miriam
AU  - Diwan, Bhalchandra A.
T1  - Carcinogenic effects of cadmium in the noble (NBL/Cr) rat: induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral prostate.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/12//
VL  - 52
IS  - 2
M3  - Article
SP  - 154
EP  - 161
PB  - Oxford University Press / USA
SN  - 10966080
AB  - Cadmium is a known human carcinogen based on findings of lung cancer in exposed populations. A more controversial target site for cadmium is the human prostate gland, for which some studies indicate a link between cadmium exposure and cancer. Our work in various strains of Wistar rats has shown that cadmium can induce tumors in the ventral lobe of the prostate. The relevance of this type of lesion to human prostate cancer has been questioned because the ventral lobe of the rat prostate, unlike the dorsolateral lobe, has no embryological homolog in the human gland. In this study we investigated the chronic toxic and carcinogenic effects of cadmium in the Noble (NBL/Cr) rat, with particular attention to lesions of the prostate. Cadmium chloride (CdCl2) was given as a single sc injection (0, 1, 2, 4, 8, 16, or 32 μmol/kg) to groups initially n=30) of 10-week-old rats. Rats were observed for up to 72 weeks following exposure. In rats that were injected with the lower doses of cadmium (≤4 μmol/kg), a clear dose-related increase in proliferative lesions of the dorsolateral prostate occurred (0 μmol/kg = 36% incidence, 1 μmol/kg = 65%; 4 μmol/kg = 79%; trend p < 0.003). Lesions were described as intraepithelial hyperplasia with occasional areas of atypical epithelial cells, without stromal invasion. At higher doses (≥8 μmol/kg) the proliferative-lesion response in the dorsolateral prostate gradually declined to near control levels (8 μmol/kg = 63%; 16 μmol/kg = 60%; 32 μmol/kg = 52%). The loss of prostatic response at the higher doses of cadmium treatment. This was reflected in a very high incidence (>90%) of lesions, indicative of testicular hypofunction, including tubular degeneration, mineralization, and interstitial (Leydig) cell tumors, at doses in excess of 16 μmol/kg. Malignant injection-site sarcomas occurred at the two highest doses of cadmium, while pituitary adenomas were elevated by cadmium exposure at the highest dose. These results show that cadmium induces proliferative lesions in the dorsolateral prostate of the Noble rat, a model having a presumed relevance to human prostate cancers. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Cadmium poisoning
KW  - Carcinogenesis
KW  - Cancer -- Risk factors
KW  - Cancer treatment
KW  - Rats
KW  - Oncology
KW  - cadmium
KW  - carcinogenesis
KW  - proliferative lesions
KW  - prostate
KW  - rat
N1  - Accession Number: 44611660; Waalkes, Michael P. 1; Email Address: waalkes@niehs.nih.gov; Anver, Miriam 2; Diwan, Bhalchandra A. 2; Affiliations: 1: Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: IRSP, SAIC Frederick, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702; Issue Info: Dec1999, Vol. 52 Issue 2, p154; Thesaurus Term: Cadmium poisoning; Thesaurus Term: Carcinogenesis; Subject Term: Cancer -- Risk factors; Subject Term: Cancer treatment; Subject Term: Rats; Subject Term: Oncology; Author-Supplied Keyword: cadmium; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: proliferative lesions; Author-Supplied Keyword: prostate; Author-Supplied Keyword: rat; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Color Photograph, 4 Charts, 1 Graph; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
AU  - Witschi, Hanspeter
AU  - Espiritu, Imelda
AU  - Pinkerton, Kent E.
AU  - Murphy, Kerry
AU  - Maronpot, Robert R.
T1  - Ozone carcinogenesis revisited.
JO  - Toxicological Sciences
JF  - Toxicological Sciences
Y1  - 1999/12//
VL  - 52
IS  - 2
M3  - Article
SP  - 162
EP  - 167
PB  - Oxford University Press / USA
SN  - 10966080
AB  - The question was asked whether ozone would act as a lung carcinogen in mice. To test the hypothesis, female strain A/J mice were exposed for 6 h/day, 5 days/week to 0.12 ppm, 0.5 ppm, or 1.0 ppm of ozone; control animals were kept in filtered air. No ozone-related deaths were observed at any time during the experiment. After 5 months, one-third of the animals were killed. The remaining animals were split into two groups: exposure to ozone continued for one group, whereas the other group was transferred into filtered air. Four months later, these animals were killed. No significant increase in lung tumor multiplicity (average number of tumors per lung) or lung tumor incidence (percentage of tumor-bearing animals) was found in the animals exposed to ozone when compared to animals kept in filtered air, regardless of ozone concentration. Morphometric analysis of lungs of animals exposed to the highest ozone concentration (1.0 ppm) showed a small, statistically not significant increase in centriacinar lesions. It was concluded that ozone is not a lung carcinogen in strain A/J mice at those exposure levels. Moreover, this mouse strain appears to be particularly resistant towards chronic ozone toxicity. [ABSTRACT FROM PUBLISHER]
AB  - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - Carcinogenesis
KW  - Ozone
KW  - Toxicology
KW  - Mice
KW  - Lung diseases
KW  - Lungs -- Cancer
KW  - carcinogen
KW  - lung tumor
KW  - ozone
KW  - strain A/J mice
N1  - Accession Number: 44611661; Witschi, Hanspeter 1,2; Email Address: hrwitschi@ucdavis.edu; Espiritu, Imelda 1; Pinkerton, Kent E. 1,3; Murphy, Kerry 1; Maronpot, Robert R. 4; Affiliations: 1: Institute of Toxicology and Environmental Health, School of Veterinary Medicine, University of California, Davis, California 95616; 2: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616; 3: Department of Anatomy/Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616; 4: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: Dec1999, Vol. 52 Issue 2, p162; Thesaurus Term: Carcinogenesis; Thesaurus Term: Ozone; Thesaurus Term: Toxicology; Thesaurus Term: Mice; Subject Term: Lung diseases; Subject Term: Lungs -- Cancer; Author-Supplied Keyword: carcinogen; Author-Supplied Keyword: lung tumor; Author-Supplied Keyword: ozone; Author-Supplied Keyword: strain A/J mice; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP  - EBSCOhost
DB  - eih
ER  - 

TY  - JOUR
ID  - 2008-13484-029
AN  - 2008-13484-029
AU  - Meunier, Martine
AU  - Bachevalier, Jocelyne
AU  - Murray, Elisabeth A.
AU  - Málková, Ludiše
AU  - Mishkin, Mortimer
T1  - Effects of aspiration versus neurotoxic lesions of the amygdala on emotional responses in monkeys.
JF  - European Journal of Neuroscience
JO  - European Journal of Neuroscience
JA  - Eur J Neurosci
Y1  - 1999/12//
VL  - 11
IS  - 12
SP  - 4403
EP  - 4418
CY  - United Kingdom
PB  - Wiley-Blackwell Publishing Ltd.
SN  - 0953-816X
SN  - 1460-9568
N1  - Accession Number: 2008-13484-029. PMID: 10594668 Partial author list: First Author & Affiliation: Meunier, Martine; Institut des Sciences Cognitives, CNRS, Bron, France. Other Publishers: Blackwell Publishing. Release Date: 20090126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Bachevalier, Jocelyne. Major Descriptor: Amygdala; Animal Emotionality; Neurotoxicity; Brain Lesions (Experimental). Minor Descriptor: Fear; Monkeys. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Dec, 1999. 
AB  - All previous reports describing alterations in emotional reactivity after amygdala damage in monkeys were based on aspiration or radiofrequency lesions which likely disrupted fibres of passage coursing to and from adjacent ventral and medial temporal cortical areas. To determine whether this associated indirect damage was responsible for some or all of the changes described earlier, we compared the changes induced by aspiration of the amygdala with those induced by fibre-sparing neurotoxic lesions. Four different stimuli, two with and two without a social component, were used to evaluate the expression of defence, aggression, submission and approach responses. In unoperated controls, defence and approach behaviours were elicited by all four stimuli, 'social' and inanimate alike, whereas aggression and submission responses occurred only in the presence of the two 'social' stimuli. Furthermore, all defence reactions were reduced with an attractive inanimate item, while freezing was selectively increased with an aversive one. Relative to controls, monkeys with neurotoxic amygdala lesions showed the same array of behavioural changes as those with aspiration lesions, i.e. reduced fear and aggression, increased submission, and excessive manual and oral exploration. Even partial neurotoxic lesions involving less than two-thirds of the amygdala significantly altered fear and manual exploration. These findings convincingly demonstrate that the amygdala is crucial for the normal regulation of emotions in monkeys. Nevertheless, because some of the symptoms observed after neurotoxic lesions were less marked than those seen after aspiration lesions, the emotional disorders described earlier after amygdalectomy in monkeys were likely exacerbated by the attendant fibre damage. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - neurotoxic lesions
KW  - amygdala
KW  - emotional responses
KW  - monkeys
KW  - medial temporal cortex
KW  - 1999
KW  - Amygdala
KW  - Animal Emotionality
KW  - Neurotoxicity
KW  - Brain Lesions (Experimental)
KW  - Fear
KW  - Monkeys
KW  - 1999
U1  - Sponsor: National Institute of Mental Health, IRP, US. Recipients: No recipient indicated
U1  - Sponsor: National Institute of Mental Health, US. Grant: 58846. Recipients: No recipient indicated
U1  - Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development, US. Grant: HD35471. Recipients: Bachevalier, Jocelyne
U1  - Sponsor: Foundation Simone and Cino Del Duca. Recipients: Meunier, Martine
U1  - Sponsor: Human Frontiers Scientific Program Organization. Recipients: Murray, Elisabeth A.
U1  - Sponsor: NATO, International Scientific Exchange Programmes. Recipients: Meunier, Martine; Bachevalier, Jocelyne
DO  - 10.1046/j.1460-9568.1999.00854.x
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UR  - ORCID: 0000-0003-1450-1642
UR  - 
UR  - Meunier@Isc.Cnrs.fr
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
ID  - 2015-44182-017
AN  - 2015-44182-017
AU  - Ralston, Evelyn
AU  - Lu, Zhuomei
AU  - Ploug, Thorkil
T1  - The organization of the Golgi complex and microtubules in skeletal muscle is fiber type-dependent.
JF  - The Journal of Neuroscience
JO  - The Journal of Neuroscience
JA  - J Neurosci
Y1  - 1999/12//
VL  - 19
IS  - 24
SP  - 10694
EP  - 10705
CY  - US
PB  - Society for Neuroscience
SN  - 0270-6474
SN  - 1529-2401
AD  - Ralston, Evelyn, Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 2A-21, Bethesda, MD, US, 20892-4062
N1  - Accession Number: 2015-44182-017. PMID: 10594053 Partial author list: First Author & Affiliation: Ralston, Evelyn; Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, US. Release Date: 20160324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ploug, Thorkil. Major Descriptor: Muscles; Golgi Apparatus. Minor Descriptor: Microscopes; Rats. Classification: Physiological Processes (2540). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Dec, 1999. Publication History: Accepted Date: Sep 27, 1999; Revised Date: Sep 20, 1999; First Submitted Date: Jul 14, 1999. Copyright Statement: Society for Neuroscience. 1999. 
AB  - Skeletal muscle has a nonconventional Golgi complex (GC), the organization of which has been a subject of controversy in the past. We have now examined the distribution of the GC by immunofluorescence and immunogold electron microscopy in whole fibers from different rat muscles, both innervated and experimentally denervated. The total number of GC elements, small polarized stacks of cisternae, is quite similar in all fibers, but their intracellular distribution is fiber type-dependent. Thus, in slow-twitch, type I fibers, ∼75% of all GC elements are located within 1 μm from the plasma membrane, and each nucleus is surrounded by a belt of GC elements. In contrast, in the fast-twitch type IIB fibers, most GC elements are in the fiber core, and most nuclei only have GC elements at their poles. Intermediate, type IIA fibers also have an intermediate distribution of GC elements. Interestingly, the distribution of microtubules, with which GC elements colocalize, is fiber type-dependent as well. At the neuromuscular junction, the distribution of GC elements and microtubules is independent of fiber type, and junctional nuclei are surrounded by GC elements in all fibers. After denervation of the hindlimb muscles, GC elements as well as microtubules converge toward a common pattern, that of the slow-twitch fibers, in all fibers. Our data suggest that innervation regulates the distribution of microtubules, which in turn organize the Golgi complex according to muscle fiber type. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW  - acetylcholine receptor
KW  - endoplasmic reticulum
KW  - flexor digitorum brevis
KW  - Golgi complex
KW  - neuromuscular junction
KW  - red gastrocnemius
KW  - trans-Golgi network
KW  - tensor fascia latae
KW  - 1999
KW  - Muscles
KW  - Golgi Apparatus
KW  - Microscopes
KW  - Rats
KW  - 1999
U1  - Sponsor: National Institutes of Health, Intramural Program, US. Recipients: No recipient indicated
U1  - Sponsor: National Research Foundation, Denmark. Grant: 504–14. Recipients: Ploug, Thorkil
U1  - Sponsor: NATO. Other Details: Collaborative Research Grant. Recipients: Ploug, Thorkil; Ralston, Evelyn
U1  - Sponsor: National Institute of Neurological Disorders and Stroke, Light Imaging Facility, US. Recipients: No recipient indicated
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UR  - esr@codon.nih.gov
DP  - EBSCOhost
DB  - psyh
ER  - 

TY  - JOUR
AU  - Müller, F.-M. C.
AU  - Lyman, C. A.
AU  - Walsh, T. J.
T1  - Antimicrobial peptides as potential new antifungals.
JO  - Mycoses
JF  - Mycoses
Y1  - 1999/12/02/1999 Supplement 2
VL  - 42
M3  - Article
SP  - 77
EP  - 82
PB  - Wiley-Blackwell
SN  - 09337407
AB  - Ribosomally synthesized natural antimicrobial peptides (AP) and their synthetic derivatives are small, cationic, amphipathic molecules of 12–50 amino acids with unusually broad activity spectra. These peptides kill microorganisms by a common mechanism, which involves binding to the lipid bilayer of biological membranes, forming pores, and ultimately followed by cell lysis. Several AP from mammals, amphibians, insects, plants and their synthetic derivatives demonstrate promising in vitro activity against various pathogenic fungi including azole-resistant Candida albicans strains. In addition to their antimicrobial activity, some AP such as lactoferrin, interact with a variety of  host cells and can increase the activity of natural killer and lymphokine activated killer cells. Pretreatment of polymorphonuclear neutrophil leukocytes (PMN) or monocytes with these AP also may upregulate superoxide release. AP as potential new antifungal agents offer some advantages, such as rapid killing of pathogenic fungi and the difficulty to raise mutants resistant to these peptides. AP are limited by their nonselective toxicity, stability, immunogenicity and their costs of production. Potential clinical applications of AP in the future have to be further explored in preclinical and clinical studies to assess their impact as a new class of antifungals. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Mycoses is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CANDIDA albicans
KW  - CANDIDA
KW  - PEPTIDE antibiotics
KW  - NEUTROPHILS
KW  - ANTIBIOTICS
KW  - ANTIFUNGAL agents
KW  - ANTI-infective agents
KW  - antifungal activity
KW  - antimicrobial activity
KW  - host defense
KW  - Peptides
KW  - synthetic derivatives
N1  - Accession Number: 17414212; Müller, F.-M. C. 1; Email Address: fmmueller@mail.uni-wuerzburg.de Lyman, C. A. 2 Walsh, T. J. 2; Affiliation:  1: Institut für Molekular Infektionsbiologie, Universität Würzburg, Germany  2: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 1999 Supplement 2, Vol. 42, p77; Subject Term: CANDIDA albicans; Subject Term: CANDIDA; Subject Term: PEPTIDE antibiotics; Subject Term: NEUTROPHILS; Subject Term: ANTIBIOTICS; Subject Term: ANTIFUNGAL agents; Subject Term: ANTI-infective agents; Author-Supplied Keyword: antifungal activity; Author-Supplied Keyword: antimicrobial activity; Author-Supplied Keyword: host defense; Author-Supplied Keyword: Peptides; Author-Supplied Keyword: synthetic derivatives; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107092434
T1  - Importance of deficits in executive functions.
AU  - Grafman J
AU  - Litvan I
Y1  - 1999/12/04/
N1  - Accession Number: 107092434. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - Cognition Disorders -- Diagnosis
KW  - Brain Diseases -- Diagnosis
KW  - Frontal Lobe -- Physiology
KW  - Adolescence
KW  - Neuropsychological Tests
KW  - Brain Diseases -- Physiopathology
KW  - Adult
KW  - Aged
KW  - Cognition Disorders -- Drug Therapy
SP  - 1921
EP  - 1923
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 354 North American Edition
IS  - 9194
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1440
U2  - PMID: 10622291.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Horne III, McDonald K.
AU  - Chang, Richard
AU  - Horne, M K 3rd
AU  - Chang, R
T1  - Thrombolytic therapy for deep venous thrombosis?
JO  - JAMA: Journal of the American Medical Association
JF  - JAMA: Journal of the American Medical Association
Y1  - 1999/12/08/
VL  - 282
IS  - 22
M3  - journal article
SP  - 2164
EP  - 2166
SN  - 00987484
AB  - We present the case of a man bedridden by deep venous thrombosis who was given intraclot instillations of recombinant tissue plasminogen activator with remarkable improvement. Although such aggressive treatment may be justified in severe cases, the role for thrombolytic agents for less symptomatic deep venous thrombosis is undefined. We discuss the question of when thrombolytic therapy should be considered. However, proper clinical trials are needed before firm recommendations can be made. [ABSTRACT FROM AUTHOR]
AB  - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - THROMBOPHLEBITIS -- Treatment
KW  - TISSUE plasminogen activator
KW  - FIBRINOLYTIC agents
KW  - THROMBOLYTIC therapy
KW  - THERAPEUTIC use
N1  - Accession Number: 2565371; Horne III, McDonald K. Chang, Richard Horne, M K 3rd 1 Chang, R; Affiliation:  1: Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 12/8/99, Vol. 282 Issue 22, p2164; Subject Term: THROMBOPHLEBITIS -- Treatment; Subject Term: TISSUE plasminogen activator; Subject Term: FIBRINOLYTIC agents; Subject Term: THROMBOLYTIC therapy; Subject Term: THERAPEUTIC use; Number of Pages: 3p; Illustrations: 6 Black and White Photographs; Document Type: journal article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107095373
T1  - Real-time three-dimensional echocardiography or measurement of left ventricular volumes.
AU  - Schmidt MA
AU  - Ohazama CJ
AU  - Agyeman KO
AU  - Freidlin RZ
AU  - Jones M
AU  - Laurienzo JM
AU  - Brenneman CL
AU  - Arai AE
AU  - von Ramm OT
AU  - Panza JA
Y1  - 1999/12/15/
N1  - Accession Number: 107095373. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by Grant HL-58104 from the National Heart, Lung, and Blood Institute, Bethesda, MD; and Grant CDR8622201 from the National Science Foundation, Arlington, VA. NLM UID: 0207277. 
KW  - Heart Ventricle -- Ultrasonography
KW  - Echocardiography -- Methods
KW  - Magnetic Resonance Imaging
KW  - Electrocardiography
KW  - Interrater Reliability
KW  - Funding Source
KW  - Human
SP  - 1434
EP  - 1439
JO  - American Journal of Cardiology
JF  - American Journal of Cardiology
JA  - AM J CARDIOL
VL  - 84
IS  - 12
CY  - Philadelphia, Pennsylvania
PB  - Elsevier Inc.
SN  - 0002-9149
AD  - Cardiology Branch, Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, Center for Information Technology, Bethesda, MD
U2  - PMID: 10606118.
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
AU  - Theis, Karsten
AU  - Chen, Paul J.
AU  - Skorvaga, Milan
AU  - Van Houten, Bennett
AU  - Kisker, Caroline
T1  - Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/12/15/
VL  - 18
IS  - 24
M3  - Article
SP  - 6899
EP  - 6907
SN  - 02614189
AB  - Nucleotide excision repair (NER) is a highly conserved DNA repair mechanism. NER systems recognize the damaged DNA strand, cleave it on both sides of the lesion, remove and newly synthesize the fragment. UvrB is a central component of the bacterial NER system participating in damage recognition, strand excision and repair synthesis. We have solved the crystal structure of UvrB in the apo and the ATP-bound forms. UvrB contains two domains related in structure to helicases, and two additional domains unique to repair proteins. The structure contains all elements of an intact helicase, and is evidence that UvrB utilizes ATP hydrolysis to move along the DNA to probe for damage. The location of conserved residues and structural comparisons allow us to predict the path of the DNA and suggest that the tight preincision complex of UvrB and the damaged DNA is formed by insertion of a flexible β-hairpin between the two DNA strands. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - CRYSTALLOGRAPHY
KW  - DNA damage
KW  - DNA helicases
KW  - DNA repair
KW  - NUCLEOTIDES
KW  - BIOCHEMICAL genetics
KW  - crystallography
KW  - dna damage
KW  - helicase
KW  - nucleotide excision repair
KW  - uvrb
N1  - Accession Number: 13004508; Theis, Karsten 1 Chen, Paul J. 1 Skorvaga, Milan 2,3 Van Houten, Bennett 2 Kisker, Caroline 1; Email Address: kisker@pharm.sunysb.edu; Affiliation:  1: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY  2: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA  3: Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Vlarska, Bratislava, Slovakia; Source Info: 12/15/99, Vol. 18 Issue 24, p6899; Subject Term: CRYSTALLOGRAPHY; Subject Term: DNA damage; Subject Term: DNA helicases; Subject Term: DNA repair; Subject Term: NUCLEOTIDES; Subject Term: BIOCHEMICAL genetics; Author-Supplied Keyword: crystallography; Author-Supplied Keyword: dna damage; Author-Supplied Keyword: helicase; Author-Supplied Keyword: nucleotide excision repair; Author-Supplied Keyword: uvrb; Number of Pages: 9p; Document Type: Article
L3  - 10.1093/emboj/18.24.6899
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004508&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Herbst, Ronald
AU  - Xiaolong Zhang
AU  - Jun Qin
AU  - Simon, Michael A.
T1  - Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the Sevenless receptor tyrosine kinase.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/12/15/
VL  - 18
IS  - 24
M3  - Article
SP  - 6950
EP  - 6961
SN  - 02614189
AB  - The pleckstrin homology (PH) domain-containing protein Daughter of Sevenless (DOS) is an essential component of the Sevenless receptor tyrosine kinase (SEV) signaling cascade, which specifies R7 photoreceptor development in the Drosophila eye. Previous results have suggested that DOS becomes tyrosine phosphorylated during SEV signaling and collaborates with the protein tyrosine phosphatase CSW. We have investigated this possibility by identifying tyrosine residues 801 and 854 of DOS as the phosphorylated binding sites for the CSW SH2 domains. We show that these sites become phosphorylated in response to SEV activation and that phosphorylation of both sites is required to allow CSW to bind DOS. Mutant DOS proteins in which either Y801 or Y854 of DOS has been changed to phenylalanine are unable to function during signaling by SEV and other receptor tyrosine kinases. In contrast, we find that a mutant DOS protein in which all tyrosine phosphorylation sites except Y801 and Y854 have been removed is able effectively to provide DOS function during SEV signaling and to rescue the lethality associated with dos loss-of-function mutations. These results indicate that a primary role for DOS during signaling by SEV and other receptor tyrosine kinases is to become phosphorylated at Y801 and Y854 and then recruit CSW. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - PROTEIN-tyrosine phosphatase
KW  - CELLULAR signal transduction
KW  - PHOTORECEPTORS
KW  - BINDING sites (Biochemistry)
KW  - LIGANDS (Biochemistry)
KW  - COMPOUND eye
KW  - DROSOPHILA
KW  - corkscrew
KW  - daughter of sevenless
KW  - protein tyrosine phosphatase
KW  - sevenless
KW  - signal transduction
N1  - Accession Number: 13004503; Herbst, Ronald 1,2 Xiaolong Zhang 3,4 Jun Qin 3,4 Simon, Michael A. 1; Email Address: msimon@leland.stanford.edu; Affiliation:  1: Department of Biological Sciences, Stanford University, Stanford, CA  2: DNAX Research Institute, 901 California, Avenue, Palo Alto, CA  3: Laboratory of Biophysical Chemistry NHLBI National Institutes of Health, Bethesda, MD, USA  4: Department of Biochemistry and Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA; Source Info: 12/15/99, Vol. 18 Issue 24, p6950; Subject Term: PROTEIN-tyrosine phosphatase; Subject Term: CELLULAR signal transduction; Subject Term: PHOTORECEPTORS; Subject Term: BINDING sites (Biochemistry); Subject Term: LIGANDS (Biochemistry); Subject Term: COMPOUND eye; Subject Term: DROSOPHILA; Author-Supplied Keyword: corkscrew; Author-Supplied Keyword: daughter of sevenless; Author-Supplied Keyword: protein tyrosine phosphatase; Author-Supplied Keyword: sevenless; Author-Supplied Keyword: signal transduction; Number of Pages: 12p; Document Type: Article
L3  - 10.1093/emboj/18.24.6950
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004503&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Jian-Min Zhang
AU  - Xiaohang Zhao
AU  - Qin Wei
AU  - Paterson, Bruce M.
T1  - Direct inhibition of G1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation.
JO  - EMBO Journal
JF  - EMBO Journal
Y1  - 1999/12/15/
VL  - 18
IS  - 24
M3  - Article
SP  - 6983
EP  - 6993
SN  - 02614189
AB  - MyoD has been proposed to facilitate terminal myoblast differentiation by binding to and inhibiting phosphorylation of the retinoblastoma protein (pRb). Here we show that MyoD can interact with cyclin-dependent kinase 4 (cdk4) through a conserved 15 amino acid (aa) domain in the C-terminus of MyoD. MyoD, its C-terminus lacking the basic helix-loop—helix (bHLH) domain, or the 15 aa cdk4-binding domain all inhibit the cdk4-dependent phosphorylation of pRb in vitro. Cellular expression of full-length MyoD or fusion proteins containing either the C-terminus or just the 15 aa cdk4-binding domain of MyoD inhibit cell growth and pRb phosphorylation in vivo. The minimal cdk4-binding domain of MyoD fused to GFP can also induce differentiation of C2C12 muscle cells in growth medium. The defective myogenic phenotype in MyoD-negative BC3H1 cells can be rescued completely only when MyoD contains the cdk4-binding domain. We propose that a regulatory checkpoint in the terminal cell cycle arrest of the myoblast during differentiation involves the modulation of the cyclin D cdk-dependent phosphorylation of pRb through the opposing effects of cyclin D1 and MyoD. [ABSTRACT FROM AUTHOR]
AB  - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - MYOBLASTS
KW  - MYOGENESIS
KW  - CELL differentiation -- Molecular aspects
KW  - BINDING sites (Biochemistry)
KW  - CELL cycle
KW  - PROTEIN kinases
KW  - cell cycle
KW  - g1 cdks
KW  - myod
KW  - myogenesis
N1  - Accession Number: 13004500; Jian-Min Zhang 1 Xiaohang Zhao 1 Qin Wei 1 Paterson, Bruce M. 1; Email Address: bruce@sunspot.nci.nih.gov; Affiliation:  1: Laboratory of Biochemistry, NCI, National Institutes of Health, Building, Rockville Pike, Bethesda, MD, USA; Source Info: 12/15/99, Vol. 18 Issue 24, p6983; Subject Term: MYOBLASTS; Subject Term: MYOGENESIS; Subject Term: CELL differentiation -- Molecular aspects; Subject Term: BINDING sites (Biochemistry); Subject Term: CELL cycle; Subject Term: PROTEIN kinases; Author-Supplied Keyword: cell cycle; Author-Supplied Keyword: g1 cdks; Author-Supplied Keyword: myod; Author-Supplied Keyword: myogenesis; Number of Pages: 11p; Document Type: Article
L3  - 10.1093/emboj/18.24.6983
UR  - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13004500&site=ehost-live&scope=site
DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
AU  - Johnson, Warren E.
AU  - Slattery, Jill Pecon
AU  - Eizirik, Eduardo
AU  - Kim, Jae-Heup
AU  - Menotti Raymond, Marilyn
AU  - Bonacic, Cristian
AU  - Cambre, Richard
AU  - Crawshaw, Peter
AU  - Nunes, Adauto
AU  - Seuánez, Héctor N.
AU  - Martins Moreira, Miguel Angelo
AU  - Seymour, Kevin L.
AU  - Simon, Faiçal
AU  - Swanson, William
AU  - O’Brien, Stephen J.
T1  - Disparate phylogeographic patterns of molecular genetic variation in four closely related South American small cat species.
JO  - Molecular Ecology
JF  - Molecular Ecology
Y1  - 1999/12/15/Dec99 Supplement 1
VL  - 8
M3  - Article
SP  - S79
EP  - S94
PB  - Wiley-Blackwell
SN  - 09621083
AB  - Tissue specimens from four species of Neotropical small cats (Oncifelis geoffroyi, N = 38; O. guigna, N = 6; Leopardus tigrinus, N = 32; Lynchailurus colocolo, N = 22) collected from throughout their distribution were examined for patterns of DNA sequence variation using three mitochondrial genes, 16S rRNA, ATP8, and NADH-5. Patterns between and among O. guigna and O. geoffroyi individuals were assessed further from size variation at 20 microsatellite loci. Phylogenetic analyses using mitochondrial DNA sequences revealed monophyletic clustering of the four species, plus evidence of natural hybridization between L. tigrinus and L. colocolo in areas of range overlap and discrete population subdivisions reflecting geographical isolation. Several commonly accepted subspecies partitions were affirmed for L. colocolo, but not for O. geoffroyi. The lack of geographical substructure in O. geoffroyi was recapitulated with the microsatellite data, as was the monophyletic clustering of O. guigna and O. geoffroyi individuals. L. tigrinus forms two phylogeographic clusters which correspond to L.t. oncilla (from Costa Rica) and L.t. guttula (from Brazil) and which have mitochondrial DNA (mtDNA) genetic distance estimates comparable to interspecific values between other ocelot lineage species. Using feline-specific calibration rates for mitochondrial DNA mutation rates, we estimated that extant lineages of O. guigna diverged 0.4 million years ago (Ma), compared with 1.7 Ma for L. colocolo, 2.0 Ma for O. geoffroyi, and 3.7 Ma for L. tigrinus. [ABSTRACT FROM AUTHOR]
AB  - Copyright of Molecular Ecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW  - EVOLUTIONARY theories
KW  - MICROSATELLITES (Genetics)
KW  - MITOCHONDRIAL DNA
KW  - PHYLOGEOGRAPHY
KW  - FELIDAE
KW  - CONSERVATION biology
KW  - HYBRIDIZATION
KW  - NUCLEOTIDE sequence
KW  - SOUTH America
KW  - conservation genetics
KW  - evolution
KW  - microsatellites
KW  - mitochondrial DNA
KW  - phylogeography
KW  - South American felids
N1  - Accession Number: 5189905; Johnson, Warren E. 1 Slattery, Jill Pecon 1 Eizirik, Eduardo 1 Kim, Jae-Heup 1 Menotti Raymond, Marilyn 1 Bonacic, Cristian 2 Cambre, Richard 3 Crawshaw, Peter 4 Nunes, Adauto 5 Seuánez, Héctor N. 6 Martins Moreira, Miguel Angelo 6 Seymour, Kevin L. 7 Simon, Faiçal 7 Swanson, William 8 O’Brien, Stephen J. 1; Affiliation:  1: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702–1201, USA,  2: Departamento de Ingenieria Forestal, Universidad Catolica, Chile,  3: Department of Animal Health, National Zoological Park, Washington DC, USA,  4: CENAP/IBAMA, Sorocaba, Brazil,  5: Zoo Municipal de Sorocaba, Brazil, **Instituto Nacional de Cancer, Serviço de Pesquisa Básica, Rio de Janeiro, Brazil,  6: Department of Palaeobiology, Royal Ontario Museum, 100 Queen’s Park, Toronto, Ontario, Canada M5S 2C6,  7: Parque Zoologico de Sao Paulo, Sao Paulo, Brazil,  8: Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA; Source Info: Dec99 Supplement 1, Vol. 8, pS79; Subject Term: EVOLUTIONARY theories; Subject Term: MICROSATELLITES (Genetics); Subject Term: MITOCHONDRIAL DNA; Subject Term: PHYLOGEOGRAPHY; Subject Term: FELIDAE; Subject Term: CONSERVATION biology; Subject Term: HYBRIDIZATION; Subject Term: NUCLEOTIDE sequence; Subject Term: SOUTH America; Author-Supplied Keyword: conservation genetics; Author-Supplied Keyword: evolution; Author-Supplied Keyword: microsatellites; Author-Supplied Keyword: mitochondrial DNA; Author-Supplied Keyword: phylogeography; Author-Supplied Keyword: South American felids; Number of Pages: 16p; Document Type: Article
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DP  - EBSCOhost
DB  - aph
ER  - 

TY  - JOUR
ID  - 107005173
T1  - Update on the treatment of neutropenia in HIV-infected patients.
AU  - Piscitelli SC
Y1  - 1999/12/16/1999 Dec 15 Suppl 5
N1  - Accession Number: 107005173. Language: English. Entry Date: 20010309. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 1999 Dec 15 Suppl 5. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023. 
KW  - Neutropenia
KW  - HIV Infections -- Complications
SP  - S3
EP  - 20
JO  - American Journal of Health-System Pharmacy
JF  - American Journal of Health-System Pharmacy
JA  - AM J HEALTH SYST PHARM AJHP
VL  - 56
IS  - 24
CY  - Bethesda, Maryland
PB  - American Society of Health System Pharmacists
SN  - 1079-2082
AD  - Coordinator, Clinical Pharmacokinetics Laboratory, Warren G. Magnuson Clinical Center, Building 10, Room 1N257, National Institutes of Health, Bethesda, MD 20892-1196
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DP  - EBSCOhost
DB  - rzh
ER  - 

TY  - JOUR
ID  - 107094714
T1  - Sorting out sleep in patients with Alzheimer's disease.
AU  - Foley D
Y1  - 1999/12/18/
N1  - Accession Number: 107094714. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R. 
KW  - Sleep Disorders -- Etiology
KW  - Alzheimer's Disease -- Complications
KW  - Sleep Disorders -- Therapy
KW  - Caregivers
SP  - 2098
EP  - 2099
JO  - Lancet
JF  - Lancet
JA  - LANCET
VL  - 354 North American Edition
IS  - 9196
CY  - Philadelphia, Pennsylvania
PB  - Lancet
SN  - 0099-5355
AD  - Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD 20892
U2  - PMID: 10609812.
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DP  - EBSCOhost
DB  - rzh
ER  -